BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P15790 (372 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4LFI-A nrPDB 768 0.0 6O6Q-A nrPDB 417 e-117 6HMD-A nrPDB 382 e-106 4MD7-E nrPDB 380 e-106 6EII-A nrPDB 376 e-104 2PVN-A nrPDB 364 e-101 5XVU-A nrPDB 348 2e-96 3NIZ-A nrPDB 139 3e-33 4E7W-A nrPDB 133 1e-31 4KRC-A nrPDB 131 4e-31 1G3N-A nrPDB 131 5e-31 3EB0-A nrPDB 129 2e-30 1V0B-A nrPDB 127 6e-30 1UA2-A nrPDB 127 7e-30 4AU8-A nrPDB 127 8e-30 3OHT-A nrPDB 125 4e-29 5AIR-A nrPDB 124 5e-29 5Z33-A nrPDB 124 8e-29 4MYG-A nrPDB 121 5e-28 4EWQ-A nrPDB 120 7e-28 6GU6-A nrPDB 120 1e-27 2BPM-A nrPDB 116 1e-26 3E3P-A nrPDB 115 4e-26 5G6V-A nrPDB 113 1e-25 1CM8-A nrPDB 113 1e-25 3GC9-A nrPDB 113 1e-25 5NGU-A nrPDB 112 3e-25 4BGQ-A nrPDB 109 2e-24 3OZ6-A nrPDB 107 6e-24 4QNY-A nrPDB 106 2e-23 4QTB-A nrPDB 104 5e-23 2F9G-A nrPDB 104 6e-23 4BBM-A nrPDB 103 2e-22 4IC8-A nrPDB 101 5e-22 6DTL-A nrPDB 101 6e-22 4ZSG-A nrPDB 100 7e-22 3GC0-A nrPDB 100 8e-22 4AGU-A nrPDB 100 2e-21 2W96-B nrPDB 100 2e-21 5EFQ-A nrPDB 99 4e-21 3MIA-A nrPDB 97 8e-21 3ZDU-A nrPDB 96 3e-20 3NIE-A nrPDB 96 4e-20 3PG1-A nrPDB 95 5e-20 4O2Z-A nrPDB 94 1e-19 3RP9-A nrPDB 93 2e-19 3E7O-A nrPDB 92 4e-19 2XS0-A nrPDB 91 8e-19 4NST-A nrPDB 89 3e-18 3N9X-A nrPDB 89 3e-18 4F9B-A nrPDB 88 5e-18 5AWM-A nrPDB 86 3e-17 1JNK-A nrPDB 86 3e-17 3FI2-A nrPDB 85 6e-17 4NIF-A nrPDB 84 7e-17 2I6L-A nrPDB 84 9e-17 6QAU-A nrPDB 84 9e-17 5Y86-A nrPDB 84 9e-17 3Q5I-A nrPDB 84 1e-16 3D2K-A nrPDB 82 3e-16 3HKO-A nrPDB 82 3e-16 4MVF-A nrPDB 82 4e-16 4UZD-A nrPDB 82 4e-16 3LIJ-A nrPDB 81 6e-16 2X4F-A nrPDB 80 1e-15 4JG6-A nrPDB 80 1e-15 3DXN-A nrPDB 80 1e-15 3HZT-A nrPDB 80 2e-15 2YAB-A nrPDB 79 2e-15 2A27-A nrPDB 78 5e-15 3DFA-A nrPDB 78 6e-15 1ZWS-A nrPDB 78 6e-15 3NCG-A nrPDB 78 7e-15 2Y7J-A nrPDB 77 9e-15 2QNJ-A nrPDB 77 1e-14 4YNZ-A nrPDB 77 1e-14 5ZTN-A nrPDB 77 1e-14 5YV8-A nrPDB 75 3e-14 6CMJ-A nrPDB 75 3e-14 3F3Z-A nrPDB 75 3e-14 2HAK-A nrPDB 75 4e-14 4RC3-A nrPDB 75 4e-14 4WNO-A nrPDB 75 5e-14 5TUR-A nrPDB 75 5e-14 3BGP-A nrPDB 75 5e-14 5WAX-A nrPDB 75 5e-14 5UNP-A nrPDB 75 6e-14 5KZ7-A nrPDB 74 7e-14 6C9D-A nrPDB 74 8e-14 3MN3-A nrPDB 74 9e-14 5JN2-A nrPDB 74 1e-13 3TAC-A nrPDB 74 1e-13 5ES1-A nrPDB 74 1e-13 4B8L-A nrPDB 74 1e-13 3MA6-A nrPDB 73 2e-13 3KN6-A nrPDB 73 2e-13 6FDY-U nrPDB 72 3e-13 2WO6-A nrPDB 72 3e-13 2W4O-A nrPDB 72 3e-13 2J90-A nrPDB 72 3e-13 4CFF-A nrPDB 72 4e-13 5EZV-A nrPDB 72 4e-13 1NY3-A nrPDB 72 4e-13 3H4J-B nrPDB 72 4e-13 2OZA-A nrPDB 72 5e-13 5D9K-A nrPDB 72 5e-13 6CKI-A nrPDB 72 5e-13 5YKS-A nrPDB 72 6e-13 4X7Q-B nrPDB 71 7e-13 4CQG-A nrPDB 71 7e-13 4RGJ-A nrPDB 71 9e-13 4CRL-A nrPDB 71 9e-13 4D2V-A nrPDB 70 1e-12 3KA0-A nrPDB 70 1e-12 4D28-A nrPDB 70 2e-12 3RAW-A nrPDB 70 2e-12 5XZW-A nrPDB 70 2e-12 1KOB-A nrPDB 70 2e-12 4CZT-A nrPDB 70 2e-12 2YZA-A nrPDB 69 2e-12 6E9W-A nrPDB 69 3e-12 2WQN-A nrPDB 69 3e-12 3HDN-A nrPDB 69 3e-12 4YZB-A nrPDB 69 4e-12 3UC3-A nrPDB 69 4e-12 1FOT-A nrPDB 69 4e-12 5IG1-A nrPDB 69 4e-12 2YCR-A nrPDB 69 5e-12 4CFH-A nrPDB 68 5e-12 4REW-A nrPDB 68 7e-12 4PDS-A nrPDB 68 7e-12 3GUB-A nrPDB 67 9e-12 2Z7Q-A nrPDB 67 1e-11 4C0T-A nrPDB 67 1e-11 4AF3-A nrPDB 67 1e-11 3I6U-A nrPDB 67 1e-11 2JC6-A nrPDB 67 1e-11 2PMN-X nrPDB 67 1e-11 3FXW-A nrPDB 67 1e-11 4L42-A nrPDB 67 2e-11 4RED-A nrPDB 67 2e-11 3UTO-A nrPDB 66 2e-11 4FG9-A nrPDB 66 2e-11 3BHH-A nrPDB 66 2e-11 4RLP-A nrPDB 66 2e-11 1KOA-A nrPDB 66 2e-11 2HW6-A nrPDB 66 3e-11 2BRG-A nrPDB 66 3e-11 1TKI-A nrPDB 65 3e-11 5TQX-A nrPDB 65 4e-11 3DAK-A nrPDB 65 4e-11 2JAM-A nrPDB 65 4e-11 4JXF-A nrPDB 65 5e-11 3ORZ-A nrPDB 65 5e-11 5UUU-A nrPDB 65 6e-11 3PVW-A nrPDB 64 9e-11 5U6Y-A nrPDB 64 9e-11 3ZUT-A nrPDB 64 1e-10 6F3F-A nrPDB 64 1e-10 5F9E-A nrPDB 64 1e-10 2VZ6-A nrPDB 64 1e-10 5FG8-A nrPDB 64 1e-10 1ZXE-A nrPDB 64 1e-10 4IAN-A nrPDB 64 2e-10 1PHK-A nrPDB 63 2e-10 5JZN-A nrPDB 63 2e-10 6DBM-A nrPDB 63 2e-10 6BDL-A nrPDB 63 2e-10 3UDB-A nrPDB 62 3e-10 6CCF-A nrPDB 62 3e-10 2DQ7-X nrPDB 62 3e-10 3SOA-A nrPDB 62 3e-10 2VN9-A nrPDB 62 4e-10 4OLI-A nrPDB 62 4e-10 6ED6-A nrPDB 62 5e-10 5SYS-A nrPDB 62 5e-10 4QMW-A nrPDB 62 5e-10 2H8H-A nrPDB 62 5e-10 2BDW-A nrPDB 62 6e-10 4EQM-A nrPDB 61 6e-10 3LLT-A nrPDB 61 6e-10 5O2C-A nrPDB 61 6e-10 3QA8-A nrPDB 61 7e-10 5O2B-A nrPDB 61 7e-10 5X8I-B nrPDB 61 8e-10 5DYK-A nrPDB 61 8e-10 2XNP-A nrPDB 61 8e-10 3A8W-A nrPDB 61 8e-10 2JD5-A nrPDB 61 9e-10 3KK8-A nrPDB 61 9e-10 5FET-A nrPDB 60 1e-09 4AW2-A nrPDB 60 1e-09 2R2P-A nrPDB 60 2e-09 3C51-A nrPDB 60 2e-09 2XIK-A nrPDB 60 2e-09 4KIK-B nrPDB 60 2e-09 4FIE-A nrPDB 59 2e-09 3ORP-A nrPDB 59 3e-09 2JDO-A nrPDB 59 3e-09 4GS6-A nrPDB 59 3e-09 3M42-A nrPDB 59 4e-09 5HI2-A nrPDB 59 4e-09 2WTK-C nrPDB 59 4e-09 6E2O-A nrPDB 59 4e-09 5LOH-A nrPDB 59 4e-09 3IS5-A nrPDB 59 4e-09 3NYO-A nrPDB 58 5e-09 2PZI-A nrPDB 58 6e-09 2Q0N-A nrPDB 58 6e-09 4JDH-A nrPDB 58 7e-09 5KCV-A nrPDB 58 7e-09 6HXF-B nrPDB 58 7e-09 6FYV-A nrPDB 58 8e-09 4XBR-A nrPDB 58 8e-09 4KS7-A nrPDB 58 8e-09 4P5Q-A nrPDB 58 8e-09 3MV5-A nrPDB 58 9e-09 5DBX-A nrPDB 57 9e-09 3TKU-A nrPDB 57 9e-09 3VN9-A nrPDB 57 1e-08 3DLS-A nrPDB 57 1e-08 3TXO-A nrPDB 57 1e-08 4Y12-A nrPDB 57 1e-08 1VZO-A nrPDB 57 2e-08 4FR4-A nrPDB 57 2e-08 5N23-A nrPDB 57 2e-08 3FME-A nrPDB 57 2e-08 4FZF-B nrPDB 56 2e-08 4EBW-A nrPDB 56 2e-08 6FD3-A nrPDB 56 2e-08 4WB7-A nrPDB 56 3e-08 5X3F-B nrPDB 56 3e-08 5HIE-A nrPDB 56 3e-08 2F57-A nrPDB 55 3e-08 4RA4-A nrPDB 55 3e-08 4I6B-A nrPDB 55 4e-08 4E20-A nrPDB 55 4e-08 4YHJ-A nrPDB 55 5e-08 3OMV-A nrPDB 55 5e-08 3Q53-A nrPDB 55 5e-08 6CTH-A nrPDB 55 6e-08 3A4O-X nrPDB 55 6e-08 4B6L-A nrPDB 55 6e-08 4CSV-A nrPDB 54 9e-08 5D7A-A nrPDB 54 1e-07 2J0K-A nrPDB 54 1e-07 6DBN-A nrPDB 54 1e-07 3COM-A nrPDB 54 1e-07 3ALO-A nrPDB 54 1e-07 4TNB-A nrPDB 54 2e-07 2VD5-A nrPDB 54 2e-07 1U5R-A nrPDB 53 2e-07 6BXI-A nrPDB 53 2e-07 2GCD-A nrPDB 53 2e-07 4E93-A nrPDB 53 2e-07 4PL5-B nrPDB 53 3e-07 2UV2-A nrPDB 52 3e-07 2Y6O-A nrPDB 52 3e-07 4UY9-A nrPDB 52 3e-07 3PFQ-A nrPDB 52 3e-07 3DTC-A nrPDB 52 3e-07 5J5T-A nrPDB 52 4e-07 2V7O-A nrPDB 52 4e-07 6HV0-A nrPDB 52 4e-07 4PWN-A nrPDB 52 4e-07 2I0E-A nrPDB 52 5e-07 4LG4-A nrPDB 51 6e-07 2OU7-A nrPDB 51 8e-07 6AO5-A nrPDB 51 1e-06 4U41-A nrPDB 51 1e-06 4J52-A nrPDB 50 1e-06 3CJF-A nrPDB 50 1e-06 6GQK-A nrPDB 50 1e-06 6CQF-A nrPDB 50 1e-06 4LQP-A nrPDB 50 2e-06 3KUL-B nrPDB 50 2e-06 4K33-A nrPDB 50 2e-06 3VHK-A nrPDB 50 2e-06 5KKR-C nrPDB 49 2e-06 3DB8-A nrPDB 49 3e-06 3EQC-A nrPDB 49 3e-06 2PSQ-A nrPDB 49 3e-06 2BUJ-A nrPDB 49 4e-06 3DKO-A nrPDB 49 4e-06 4NEU-A nrPDB 49 5e-06 3BEA-A nrPDB 48 5e-06 2HK5-A nrPDB 48 6e-06 1S9I-A nrPDB 48 6e-06 4AN9-A nrPDB 48 8e-06 5A46-A nrPDB 48 9e-06 2VWV-A nrPDB 47 9e-06 4X3F-A nrPDB 47 9e-06 3KRL-A nrPDB 47 9e-06 4OW8-A nrPDB 47 1e-05 3TT0-A nrPDB 47 1e-05 5O0Y-A nrPDB 47 1e-05 5MJB-A nrPDB 47 1e-05 6E4F-A nrPDB 47 1e-05 3GQL-A nrPDB 47 1e-05 6B2Q-A nrPDB 47 1e-05 3PLS-A nrPDB 47 1e-05 5CEK-A nrPDB 47 1e-05 6DC0-A nrPDB 47 1e-05 1JPA-A nrPDB 47 1e-05 5WNL-A nrPDB 47 1e-05 4IDT-A nrPDB 47 1e-05 4XI2-A nrPDB 47 1e-05 2PL0-A nrPDB 47 2e-05 6GVJ-A nrPDB 47 2e-05 4JRN-A nrPDB 47 2e-05 5X02-A nrPDB 47 2e-05 3HNG-A nrPDB 46 2e-05 5EG3-A nrPDB 46 2e-05 5HLW-A nrPDB 46 2e-05 5GRN-A nrPDB 46 2e-05 4H1J-A nrPDB 46 3e-05 3LM0-A nrPDB 46 3e-05 4APC-A nrPDB 46 3e-05 4XUF-A nrPDB 46 3e-05 5VD3-A nrPDB 46 3e-05 4R7H-A nrPDB 46 3e-05 4XCU-A nrPDB 46 3e-05 5HVK-A nrPDB 46 3e-05 4Y93-A nrPDB 46 3e-05 2OGV-A nrPDB 46 3e-05 4HVI-A nrPDB 46 3e-05 3HMP-A nrPDB 45 4e-05 2ZMD-A nrPDB 45 4e-05 5AP3-A nrPDB 45 4e-05 4XEY-B nrPDB 45 4e-05 6NPU-A nrPDB 45 4e-05 4RT7-A nrPDB 45 4e-05 5B2L-A nrPDB 45 5e-05 5U6B-A nrPDB 45 6e-05 5L6P-A nrPDB 45 6e-05 5H2U-A nrPDB 45 6e-05 3UIU-A nrPDB 45 7e-05 4G3E-A nrPDB 44 8e-05 3G0E-A nrPDB 44 9e-05 2W1I-A nrPDB 44 9e-05 2FO0-A nrPDB 44 9e-05 3PPZ-A nrPDB 44 9e-05 3IO7-A nrPDB 44 1e-04 5M07-A nrPDB 44 1e-04 4Y83-A nrPDB 44 1e-04 2WTK-B nrPDB 44 2e-04 4PDO-A nrPDB 44 2e-04 3QGY-A nrPDB 44 2e-04 2XYN-A nrPDB 43 2e-04 4UYA-A nrPDB 43 2e-04 4TPT-A nrPDB 43 2e-04 5L2Q-C nrPDB 43 2e-04 4JLC-A nrPDB 43 3e-04 3C1X-A nrPDB 42 3e-04 2CMW-A nrPDB 42 4e-04 4IX6-A nrPDB 42 4e-04 1AD5-A nrPDB 42 5e-04 2A1A-B nrPDB 42 5e-04 3BBT-B nrPDB 42 5e-04 4CI6-B nrPDB 42 5e-04 6NT9-A nrPDB 42 6e-04 5AMN-A nrPDB 41 8e-04 4EUU-A nrPDB 41 9e-04 5FM2-A nrPDB 41 0.001 6O8B-A nrPDB 41 0.001 4EUT-A nrPDB 41 0.001 4BTF-A nrPDB 40 0.001 4M7I-A nrPDB 40 0.001 2Y4I-B nrPDB 40 0.002 2RIO-A nrPDB 40 0.002 4M69-B nrPDB 40 0.002 1FVR-A nrPDB 40 0.002 3QD2-B nrPDB 40 0.002 5X5O-A nrPDB 39 0.003 2QKW-B nrPDB 39 0.003 5FQD-C nrPDB 39 0.003 2C47-A nrPDB 39 0.003 4M66-A nrPDB 39 0.003 3PP0-A nrPDB 39 0.003 4C59-A nrPDB 39 0.004 3ZBF-A nrPDB 39 0.005 3LZB-A nrPDB 39 0.005 4LRM-A nrPDB 39 0.005 4NFN-A nrPDB 38 0.006 5GNK-A nrPDB 38 0.006 4NT4-A nrPDB 38 0.006 4BTK-A nrPDB 38 0.006 2CHL-A nrPDB 38 0.007 4YFF-A nrPDB 38 0.007 3V5Q-A nrPDB 38 0.008 2X7G-A nrPDB 38 0.009 3QUP-A nrPDB 37 0.010 4XLV-A nrPDB 37 0.010 4TN6-A nrPDB 37 0.010 5VC6-A nrPDB 37 0.011 5VDK-A nrPDB 37 0.014 5CLR-A nrPDB 37 0.014 5WNO-A nrPDB 37 0.014 4O1O-A nrPDB 37 0.016 3SXS-A nrPDB 36 0.025 5LPZ-A nrPDB 36 0.027 1K9A-A nrPDB 36 0.027 5X18-A nrPDB 36 0.029 3SV0-A nrPDB 36 0.030 5LPV-A nrPDB 36 0.031 4HZS-A nrPDB 35 0.039 1BYG-A nrPDB 35 0.041 5IKW-A nrPDB 35 0.045 4WUA-A nrPDB 35 0.045 4AZV-A nrPDB 35 0.046 4OTD-A nrPDB 35 0.047 5XD6-A nrPDB 35 0.049 1U54-B nrPDB 35 0.060 1U59-A nrPDB 35 0.061 6G4J-A nrPDB 35 0.072 4XHH-A nrPDB 34 0.079 3UIM-A nrPDB 34 0.086 3I81-A nrPDB 34 0.086 4AZW-A nrPDB 34 0.089 4AT3-A nrPDB 34 0.089 5U6C-A nrPDB 34 0.11 4FAJ-A nrPDB 34 0.12 5VO2-A nrPDB 34 0.13 3SOC-A nrPDB 34 0.13 5TOS-A nrPDB 33 0.13 4XHL-A nrPDB 33 0.14 1CSN-A nrPDB 33 0.19 4L00-A nrPDB 33 0.20 2RSV-A nrPDB 33 0.24 2OZO-A nrPDB 33 0.24 2LAV-A nrPDB 33 0.27 5TE0-A nrPDB 32 0.41 5KMM-A nrPDB 32 0.44 6EWX-A nrPDB 32 0.45 3ZZW-A nrPDB 31 0.88 4FL3-A nrPDB 31 1.0 5UU1-A nrPDB 31 1.1 5DMZ-A nrPDB 30 1.3 5UIU-A nrPDB 30 1.3 3LMG-A nrPDB 30 1.3 3BYV-A nrPDB 30 1.3 5C26-A nrPDB 30 1.5 4CRS-A nrPDB 30 1.7 5J0A-A nrPDB 30 2.4 2AOV-A nrPDB 30 2.5 4OAU-C nrPDB 29 2.9 6J6I-B nrPDB 29 3.1 6BFN-A nrPDB 29 3.5 5OAT-A nrPDB 29 3.7 5VE6-A nrPDB 28 5.1 5AR8-A nrPDB 28 5.8 2H34-A nrPDB 28 6.0 >4LFI-A nrPDB Length = 374 Score = 768 bits (1983), Expect = 0.0, Method: Compositional matrix adjust. Identities = 372/372 (100%), Positives = 372/372 (100%) Query: 1 MKCRVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKL 60 MKCRVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKL Sbjct: 3 MKCRVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKL 62 Query: 61 DSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRP 120 DSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRP Sbjct: 63 DSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRP 122 Query: 121 YIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELL 180 YIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELL Sbjct: 123 YIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELL 182 Query: 181 KALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPE 240 KALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPE Sbjct: 183 KALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPE 242 Query: 241 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 300 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY Sbjct: 243 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 302 Query: 301 EITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGH 360 EITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGH Sbjct: 303 EITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGH 362 Query: 361 PWFAPIREQIEK 372 PWFAPIREQIEK Sbjct: 363 PWFAPIREQIEK 374 >6O6Q-A nrPDB Length = 335 Score = 417 bits (1072), Expect = e-117, Method: Compositional matrix adjust. Identities = 211/367 (57%), Positives = 262/367 (71%), Gaps = 40/367 (10%) Query: 5 VWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKV 64 V S +RVY ++ + + YWDY++ I W+ ++YEI K+GRGKYSEVF G+ L+ + Sbjct: 9 VQSVSRVYADVLSTKPQSYWDYDDLNIKWNPQ-ENYEILRKLGRGKYSEVFLGIDLEKRE 67 Query: 65 KIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFD 124 K+VIK+LKPVK+KKIKREI IL +L D Sbjct: 68 KVVIKVLKPVKRKKIKREISILKNL---------------------------------VD 94 Query: 125 QPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALD 184 P NII + D++++P SKTP L+FE+++N+DFR LYP TD +IRFYM+ELLKALD Sbjct: 95 GP-----NIIAMLDVVREPQSKTPGLIFEHINNIDFRSLYPTFTDYDIRFYMYELLKALD 149 Query: 185 YCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVD 244 Y HSMGIMHRDVKPHNVMIDH K LRLIDWGLAE+YH EYNVRVASR+FKGPELLVD Sbjct: 150 YSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPELLVD 209 Query: 245 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 YR+YDYSLD+WSFG MLASM+F +EPFFHG SNTDQLV+IV+VLG+ +F+KYL KY I+L Sbjct: 210 YRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNISL 269 Query: 305 PREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 E+ D+ Y ++ W RF+N+ NK L E +DLID LLRYDHQERLTAKEAM H +F Sbjct: 270 GEEYEDIGYYNKRQWVRFMNENNKDLVSQ-EFLDLIDRLLRYDHQERLTAKEAMKHAYFD 328 Query: 365 PIREQIE 371 PIR + Sbjct: 329 PIRVAVS 335 >6HMD-A nrPDB Length = 365 Score = 382 bits (981), Expect = e-106, Method: Compositional matrix adjust. Identities = 214/361 (59%), Positives = 253/361 (70%), Gaps = 41/361 (11%) Query: 7 SEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKI 66 S ARVY +N R+ EYWDYE V W N DY++ K+GRGKYSEVF+ + + + ++ Sbjct: 23 SRARVYAEVNSLRSREYWDYEAHVPSWG-NQDDYQLVRKLGRGKYSEVFEAINITNNERV 81 Query: 67 VIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQP 126 V+K+LKPVKKKKIKRE+KIL +L Sbjct: 82 VVKILKPVKKKKIKREVKILENL------------------------------------- 104 Query: 127 HNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYC 186 G NII L D +KDP+SKTPALVFEY++N DF+ LY LTD +IRFYM+ELLKALDYC Sbjct: 105 -RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYC 163 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYR 246 HS GIMHRDVKPHNVMIDH+ KKLRLIDWGLAEFYH EYNVRVASR+FKGPELLVDY+ Sbjct: 164 HSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQ 223 Query: 247 MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPR 306 MYDYSLD+WS G MLASMIF+REPFFHG N DQLV+I KVLGT + YL KY I L Sbjct: 224 MYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDP 283 Query: 307 EFYD-MDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 F D + Q+ RK W FI+ N+HL + E +DL+D LLRYDHQ+RLTAKEAM HP+F P Sbjct: 284 HFNDILGQHSRKRWENFIHSENRHLV-SPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYP 342 Query: 366 I 366 + Sbjct: 343 V 343 >4MD7-E nrPDB Length = 391 Score = 380 bits (976), Expect = e-106, Method: Compositional matrix adjust. Identities = 213/364 (58%), Positives = 259/364 (71%), Gaps = 41/364 (11%) Query: 1 MKCRVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKL 60 M V S ARVYT++N R EYWDYE+ V++W N DY++ K+GRGKYSEVF+ + + Sbjct: 1 MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWG-NQDDYQLVRKLGRGKYSEVFEAINI 59 Query: 61 DSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRP 120 + K+V+K+LKPVKKKKIKREIKIL +L Sbjct: 60 TNNEKVVVKILKPVKKKKIKREIKILENL------------------------------- 88 Query: 121 YIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELL 180 G NII L DI+KDP+S+TPALVFE+V+N DF+ LY LTD +IRFYM+E+L Sbjct: 89 -------RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEIL 141 Query: 181 KALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPE 240 KALDYCHSMGIMHRDVKPHNVMIDH+++KLRLIDWGLAEFYH EYNVRVASR+FKGPE Sbjct: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201 Query: 241 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 300 LLVDY+MYDYSLD+WS G MLASMIF++EPFFHG N DQLV+I KVLGT D Y+ KY Sbjct: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 Query: 301 EITLPREFYD-MDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMG 359 I L F D + ++ RK W RF++ N+HL + E +D +D LLRYDHQ RLTA+EAM Sbjct: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLV-SPEALDFLDKLLRYDHQSRLTAREAME 320 Query: 360 HPWF 363 HP+F Sbjct: 321 HPYF 324 >6EII-A nrPDB Length = 352 Score = 376 bits (965), Expect = e-104, Method: Compositional matrix adjust. Identities = 212/363 (58%), Positives = 259/363 (71%), Gaps = 41/363 (11%) Query: 5 VWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKV 64 V S ARVYT++N R EYWDYE+ V++W N DY++ K+GRGKYSEVF+ + + + Sbjct: 28 VPSRARVYTDVNTHRPSEYWDYESHVVEWG-NQDDYQLVRKLGRGKYSEVFEAINITNNE 86 Query: 65 KIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFD 124 K+V+K+LKPVKKKKIKREIKIL +L Sbjct: 87 KVVVKILKPVKKKKIKREIKILENL----------------------------------- 111 Query: 125 QPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALD 184 G NII L DI+KDP+S+TPALVFE+V+N DF+ LY LTD +IRFYM+E+LKALD Sbjct: 112 ---RGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALD 168 Query: 185 YCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVD 244 YCHSMGIMHRDVKPHNVMIDH+++KLRLIDWGLAEFYH EYNVRVASR+FKGPELLVD Sbjct: 169 YCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVD 228 Query: 245 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 Y+MYDYSLD+WS G MLASMIF++EPFFHG N DQLV+I KVLGT D Y+ KY I L Sbjct: 229 YQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIEL 288 Query: 305 PREFYD-MDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 F D + ++ RK W RF++ N+HL + E +D +D LLRYDHQ RLTA+EAM HP+F Sbjct: 289 DPRFNDILGRHSRKRWERFVHSENQHLV-SPEALDFLDKLLRYDHQSRLTAREAMEHPYF 347 Query: 364 API 366 + Sbjct: 348 YTV 350 >2PVN-A nrPDB Length = 352 Score = 364 bits (934), Expect = e-101, Method: Compositional matrix adjust. Identities = 206/362 (56%), Positives = 251/362 (69%), Gaps = 41/362 (11%) Query: 7 SEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKI 66 S+ARVY ++N R +EYWDYE + W DYE+ KVGRGKYSEVF+G+ +++ K Sbjct: 22 SKARVYADVNVLRPKEYWDYEALTVQWGEQ-DDYEVVRKVGRGKYSEVFEGINVNNNEKC 80 Query: 67 VIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQP 126 +IK+LKPVKKKKIKREIKIL +L Sbjct: 81 IIKILKPVKKKKIKREIKILQNLC------------------------------------ 104 Query: 127 HNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYC 186 G NI+ L DI++D SKTP+L+FEYV+N DF++LYP LTD +IR+Y++ELLKALDYC Sbjct: 105 --GGPNIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVLYPTLTDYDIRYYIYELLKALDYC 162 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYR 246 HS GIMHRDVKPHNVMIDH+ +KLRLIDWGLAEFYH EYNVRVASR+FKGPELLVD + Sbjct: 163 HSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQ 222 Query: 247 MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL-P 305 YDYSLD+WS G M A MIF++EPFF+G N DQLVKI KVLGT YL KY I L P Sbjct: 223 DYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIELDP 282 Query: 306 REFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 + + ++ RKPW +F+N N+HL + E ID +D LLRYDHQERLTA EAM HP+F Sbjct: 283 QLEALVGRHSRKPWLKFMNADNQHLV-SPEAIDFLDKLLRYDHQERLTALEAMTHPYFQQ 341 Query: 366 IR 367 +R Sbjct: 342 VR 343 >5XVU-A nrPDB Length = 332 Score = 348 bits (893), Expect = 2e-96, Method: Compositional matrix adjust. Identities = 192/361 (53%), Positives = 245/361 (67%), Gaps = 41/361 (11%) Query: 10 RVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIK 69 + Y ++N + +EY+DY+N + W+ + YEI K+GRGKYSEVF G + IK Sbjct: 4 KFYADVNIHKPKEYYDYDNLELQWNKPNR-YEIMKKIGRGKYSEVFNGYDTECNRPCAIK 62 Query: 70 MLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNG 129 +LKPVKKKKIKREIKIL +L NG Sbjct: 63 VLKPVKKKKIKREIKILQNL--------------------------------------NG 84 Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSM 189 NII L DI+KDP++KTP+L+FEY++N+DF+ LYPK TD +IR+Y++++LKALDYCHS Sbjct: 85 GPNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTLYPKFTDKDIRYYIYQILKALDYCHSQ 144 Query: 190 GIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYD 249 GIMHRDVKPHN+MIDH+N+++RLI WGLAEFYH EYNVRVASR++KGPELL+D ++YD Sbjct: 145 GIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRVASRYYKGPELLIDLQLYD 204 Query: 250 YSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL-PREF 308 YSLD+WS G MLA MIFK+EPFF G N DQLVKI KVLGT D YL KY I L P Sbjct: 205 YSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKYNIKLKPHYL 264 Query: 309 YDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 368 + +Y RKPW F+ N ++ DE+IDLID +L YDH +R+ KEAM HP+F +RE Sbjct: 265 NILGEYERKPWSHFLTQSNIDIA-KDEVIDLIDKMLIYDHAKRIAPKEAMEHPYFREVRE 323 Query: 369 Q 369 + Sbjct: 324 E 324 >3NIZ-A nrPDB Length = 311 Score = 139 bits (349), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 99/335 (29%), Positives = 173/335 (51%), Gaps = 50/335 (14%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 Y+ KVG G Y V++ DS+ +IV +KR I D +E +P T + Sbjct: 23 YQKLEKVGEGTYGVVYKAK--DSQGRIV----------ALKR---IRLDAEDEGIPSTAI 67 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVD 159 ++ +LK + H NI+ L D+I + LVFE+++ Sbjct: 68 ----------REISLLKELH----------HPNIVSLIDVIHS--ERCLTLVFEFMEKDL 105 Query: 160 FRIL---YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWG 216 ++L L D +I+ Y+++LL+ + +CH I+HRD+KP N++I+ + L+L D+G Sbjct: 106 KKVLDENKTGLQDSQIKIYLYQLLRGVAHCHQHRILHRDLKPQNLLIN-SDGALKLADFG 164 Query: 217 LAEFYHVNM-EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGT 275 LA + + + Y V + +++ P++L+ + Y S+D+WS G + A MI + P F G Sbjct: 165 LARAFGIPVRSYTHEVVTLWYRAPDVLMGSKKYSTSVDIWSIGCIFAEMITGK-PLFPGV 223 Query: 276 SNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDE 335 ++ DQL KI +LGT + ++ E+ L ++ + +KPW I + E Sbjct: 224 TDDDQLPKIFSILGTPNPREWPQVQELPLWKQ-RTFQVFEKKPWSSIIPGFCQ------E 276 Query: 336 IIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQI 370 IDL+ N+L +D +R++A++AM HP+F + QI Sbjct: 277 GIDLLSNMLCFDPNKRISARDAMNHPYFKDLDPQI 311 >4E7W-A nrPDB Length = 394 Score = 133 bits (334), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 82/225 (36%), Positives = 125/225 (55%), Gaps = 17/225 (7%) Query: 150 LVFEYVDNVDFRIL--YPKLTD----LEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI 203 LV EYV +R Y KL L I+ YM++LL++L Y HS+GI HRD+KP N+++ Sbjct: 115 LVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYIHSIGICHRDIKPQNLLL 174 Query: 204 DHKNKKLRLIDWGLAEFYHVNMEYNVR-VASRFFKGPELLVDYRMYDYSLDLWSFGTMLA 262 D + L+LID+G A+ + E NV + SR+++ PEL+ Y ++D+WS G ++A Sbjct: 175 DPPSGVLKLIDFGSAKIL-IAGEPNVSYICSRYYRAPELIFGATNYTTNIDIWSTGCVMA 233 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 ++ + +P F G S DQLV+I+KVLGT E+ + +F + + P+ + Sbjct: 234 ELM-QGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEHKFPQIRPH---PFSKV 289 Query: 323 INDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIR 367 + IDLI LL Y RLTA EA+ HP+F +R Sbjct: 290 FRPRTP-----PDAIDLISRLLEYTPSARLTAIEALCHPFFDELR 329 >4KRC-A nrPDB Length = 317 Score = 131 bits (330), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 96/340 (28%), Positives = 178/340 (52%), Gaps = 53/340 (15%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKV 94 +++ ++ K+G G Y+ V++G+ + V + +K E+K+ S E Sbjct: 2 SSSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALK------------EVKLD---SEEGT 46 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 P T + ++ ++K ++ H NI+ L+D+I T LVFE+ Sbjct: 47 PSTAI----------REISLMKELK----------HENIVRLYDVIHTENKLT--LVFEF 84 Query: 155 VDN-----VDFRILYPKLTDLE---IRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK 206 +DN +D R + LE ++++ ++LL+ L +CH I+HRD+KP N++I+ K Sbjct: 85 MDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLIN-K 143 Query: 207 NKKLRLIDWGLAEFYHVNME-YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 +L+L D+GLA + + + ++ V + +++ P++L+ R Y S+D+WS G +LA MI Sbjct: 144 RGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMI 203 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 + P F GT++ +QL I ++GT + + L LP+ ++ Q + + + Sbjct: 204 TGK-PLFPGTNDEEQLKLIFDIMGTPN--ESLWPSVTKLPKYNPNIQQRPPRDLRQVLQP 260 Query: 326 GNKH-LSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 K L GN ++D + LL+ + RL+AK+A+ HPWFA Sbjct: 261 HTKEPLDGN--LMDFLHGLLQLNPDMRLSAKQALHHPWFA 298 >1G3N-A nrPDB Length = 326 Score = 131 bits (329), Expect = 5e-31, Method: Compositional matrix adjust. Identities = 97/337 (28%), Positives = 172/337 (51%), Gaps = 58/337 (17%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 + YE ++G G Y +VF+ L + + V +KR +++ T E +P + Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFV----------ALKR-VRVQT--GEEGMPLS 57 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTP-----ALVF 152 T+ ++ VL+ + + H N++ LFD+ +S+T LVF Sbjct: 58 TI----------REVAVLRHLETF-------EHPNVVRLFDVCT--VSRTDRETKLTLVF 98 Query: 153 EYVDN-----VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN 207 E+VD +D ++ P + I+ MF+LL+ LD+ HS ++HRD+KP N+++ + Sbjct: 99 EHVDQDLTTYLD-KVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVT-SS 156 Query: 208 KKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 +++L D+GLA Y M V + +++ PE+L+ Y +DLWS G + A M F+ Sbjct: 157 GQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEM-FR 214 Query: 268 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGN 327 R+P F G+S+ DQL KI+ V+G E + ++ LPR+ + +P +F+ D Sbjct: 215 RKPLFRGSSDVDQLGKILDVIGLPGEEDW--PRDVALPRQAFHSKSA--QPIEKFVTD-- 268 Query: 328 KHLSGNDEII-DLIDNLLRYDHQERLTAKEAMGHPWF 363 DE+ DL+ L ++ +R++A A+ HP+F Sbjct: 269 -----IDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 >3EB0-A nrPDB Length = 383 Score = 129 bits (325), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 95/350 (27%), Positives = 171/350 (48%), Gaps = 31/350 (8%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKV 94 T++K Y + +G G + V + ++S + +K + + K RE+ I+ L + + Sbjct: 4 TSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYK-NRELDIMKVLDHVNI 62 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHN---GHANII--HLFDIIKDPI-SKTP 148 D +YT E+ +P HN G N + H +I +P +K Sbjct: 63 IKLV-----DYFYTTGDEEP----KPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYL 113 Query: 149 ALVFEYVDNVDFRILYPKLTDLE------IRFYMFELLKALDYCHSMGIMHRDVKPHNVM 202 ++ EYV + ++L + I Y+++L +A+ + HS+GI HRD+KP N++ Sbjct: 114 NVIMEYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLL 173 Query: 203 IDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLA 262 ++ K+ L+L D+G A+ + + SRF++ PEL++ Y S+DLWS G + Sbjct: 174 VNSKDNTLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFG 233 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 +I + P F G ++ DQLV+I++++GT E+ + F + K W + Sbjct: 234 ELILGK-PLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKA---KDWRKI 289 Query: 323 INDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK 372 + +G L+ IDL++ +LRY+ R+ EAM HP+F +R E Sbjct: 290 LPEGTPSLA-----IDLLEQILRYEPDLRINPYEAMAHPFFDHLRNSYES 334 >1V0B-A nrPDB Length = 288 Score = 127 bits (320), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 76/240 (31%), Positives = 135/240 (56%), Gaps = 20/240 (8%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFR----ILYPKLTDLEIRFYMFELLKALDY 185 H+NI+ L+D+I K LVFE++D D + + L + + ++ +LL + Y Sbjct: 59 HSNIVKLYDVIH--TKKRLVLVFEHLDQ-DLKKLLDVCEGGLESVTAKSFLLQLLNGIAY 115 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNM-EYNVRVASRFFKGPELLVD 244 CH ++HRD+KP N++I+ + +L++ D+GLA + + + +Y V + +++ P++L+ Sbjct: 116 CHDRRVLHRDLKPQNLLINREG-ELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMG 174 Query: 245 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 + Y ++D+WS G + A M+ P F G S DQL++I ++LGT + + + E L Sbjct: 175 SKKYSTTIDIWSVGCIFAEMV-NGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTE--L 231 Query: 305 PREFYDMDQYIRKPWHRFINDGNKHLSGNDEI-IDLIDNLLRYDHQERLTAKEAMGHPWF 363 P+ + Y PW F L G DE IDL+ +L+ D +R+TAK+A+ H +F Sbjct: 232 PKYDPNFTVYEPLPWESF-------LKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYF 284 >1UA2-A nrPDB Length = 346 Score = 127 bits (319), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 99/350 (28%), Positives = 167/350 (47%), Gaps = 70/350 (20%) Query: 30 VIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIK--------R 81 +D + K YE + +G G+++ V++ ++ + IK +K + + K R Sbjct: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 Query: 82 EIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII- 140 EIK+L +LS H NII L D Sbjct: 62 EIKLLQELS---------------------------------------HPNIIGLLDAFG 82 Query: 141 -KDPISKTPALVFEYVDNVDFRILYPK----LTDLEIRFYMFELLKALDYCHSMGIMHRD 195 K IS LVF++++ D ++ LT I+ YM L+ L+Y H I+HRD Sbjct: 83 HKSNIS----LVFDFMET-DLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRD 137 Query: 196 VKPHNVMIDHKNKKLRLIDWGLAE-FYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDL 254 +KP+N+++D +N L+L D+GLA+ F N Y +V +R+++ PELL RMY +D+ Sbjct: 138 LKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDM 196 Query: 255 WSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQY 314 W+ G +LA ++ R PF G S+ DQL +I + LGT E++ +LP ++ + Sbjct: 197 WAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQW--PDMCSLP-DYVTFKSF 252 Query: 315 IRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 P H + + D+++DLI L ++ R+TA +A+ +F+ Sbjct: 253 PGIPLHHIFS------AAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 >4AU8-A nrPDB Length = 296 Score = 127 bits (319), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 92/336 (27%), Positives = 167/336 (49%), Gaps = 51/336 (15%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 93 + ++ YE K+G G Y VF+ ++ + +K ++ D +E Sbjct: 2 AMGSQKYEKLEKIGEGTYGTVFKAKNRETHEIVALK--------------RVRLDDDDEG 47 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 VP + L ++ +LK ++ H NI+ L D++ K LVFE Sbjct: 48 VPSSAL----------REICLLKELK----------HKNIVRLHDVLHS--DKKLTLVFE 85 Query: 154 YVDNVDFRILYPKLT-DLE---IRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 + D D + + DL+ ++ ++F+LLK L +CHS ++HRD+KP N++I+ +N + Sbjct: 86 FCDQ-DLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN-RNGE 143 Query: 210 LRLIDWGLAEFYHVNME-YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 268 L+L D+GLA + + + Y+ V + +++ P++L ++Y S+D+WS G + A + Sbjct: 144 LKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAELANAG 203 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 P F G DQL +I ++LGT E++ LP D Y P + + Sbjct: 204 RPLFPGNDVDDQLKRIFRLLGTPTEEQW--PSMTKLP----DYKPYPMYPATTSLVNVVP 257 Query: 329 HLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 L+ DL+ NLL+ + +R++A+EA+ HP+F+ Sbjct: 258 KLNATGR--DLLQNLLKCNPVQRISAEEALQHPYFS 291 >3OHT-A nrPDB Length = 389 Score = 125 bits (313), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 97/378 (25%), Positives = 176/378 (46%), Gaps = 75/378 (19%) Query: 4 RVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSK 63 + S A +T +K+R Y N I W + Y+ + VG G Y V + S Sbjct: 19 KAGSAAAPFTMSHKERPTFYRQELNKTI-WEVPER-YQTLSPVGSGAYGSVCSSYDVKSG 76 Query: 64 VKIVIKML-KP----VKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFI 118 +KI +K L +P + K+ RE+++L Sbjct: 77 LKIAVKKLSRPFQSIIHAKRTYRELRLLK------------------------------- 105 Query: 119 RPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNV-----------DFRILYPKL 167 H H N+I L D+ TPA E ++V + + KL Sbjct: 106 --------HMKHENVIGLLDVF------TPATSLEEFNDVYLVTHLMGADLNNIVKCQKL 151 Query: 168 TDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEY 227 TD ++F ++++L+ L Y HS I+HRD+KP N+ ++ ++ +L+++D+GLA H + E Sbjct: 152 TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR--HTDDEM 208 Query: 228 NVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKV 287 VA+R+++ PE+++++ Y+ ++D+WS G ++A ++ R F GT + +QL +I+++ Sbjct: 209 TGYVATRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRT-LFPGTDHINQLQQIMRL 267 Query: 288 LGTSDFEKYLLKYEITLPREFYDMDQYIRK-PWHRFINDGNKHLSGNDEIIDLIDNLLRY 346 GT + ++ YI P N + + N +DL++ +L Sbjct: 268 TGTP-------PASVISRMPSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVL 320 Query: 347 DHQERLTAKEAMGHPWFA 364 D +R+TA EA+ HP+F+ Sbjct: 321 DTDKRITASEALAHPYFS 338 >5AIR-A nrPDB Length = 430 Score = 124 bits (312), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 78/226 (34%), Positives = 116/226 (51%), Gaps = 17/226 (7%) Query: 150 LVFEYVDNVDFRIL--YPK----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI 203 LV +YV +R+ Y + L + ++ YM++L ++L Y HS GI HRD+KP N+++ Sbjct: 140 LVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLL 199 Query: 204 DHKNKKLRLIDWGLAEFYHVNMEYNVR-VASRFFKGPELLVDYRMYDYSLDLWSFGTMLA 262 D L+L D+G A+ V E NV + SR+++ PEL+ Y S+D+WS G +LA Sbjct: 200 DPDTAVLKLCDFGSAK-QLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLA 258 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 ++ +P F G S DQLV+I+KVLGT E+ E+ + Q PW + Sbjct: 259 ELLLG-QPIFPGDSGVDQLVEIIKVLGTPTREQI---REMNPNYTEFKFPQIKAHPWTKV 314 Query: 323 INDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 368 E I L LL Y RLT EA H +F +R+ Sbjct: 315 FRPRTP-----PEAIALCSRLLEYTPTARLTPLEACAHSFFDELRD 355 >5Z33-A nrPDB Length = 425 Score = 124 bits (310), Expect = 8e-29, Method: Compositional matrix adjust. Identities = 92/345 (26%), Positives = 161/345 (46%), Gaps = 74/345 (21%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIK-----REIKILTDLSNEKV 94 Y + ++G+G Y V V + + IK + V KKI REIK+L Sbjct: 33 YTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLL-------- 84 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDI-IKDPISKTPALVFE 153 Q GH NI L+D+ I P + ++E Sbjct: 85 ------------------------------QHFRGHRNITCLYDMDIPRPDNFNETYLYE 114 Query: 154 YVDNVDFRILY---PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 + D + LTD + +++++L L Y HS ++HRD+KP N++++ + +L Sbjct: 115 ELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVN-ADCEL 173 Query: 211 RLIDWGLAEFYHVNMEYNVR-----VASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 ++ D+GLA + V+ E N VA+R+++ PE+++ ++ Y ++D+WS G +LA ++ Sbjct: 174 KICDFGLARGFSVDPEENAGYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELL 233 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIR-------KP 318 R PFF G DQL +I+ +LGT + E I PR +Y+R KP Sbjct: 234 GGR-PFFKGRDYVDQLNQILHILGTPNEETL---SRIGSPR----AQEYVRNLPFMAKKP 285 Query: 319 WHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + + N + +DL+D +L +D R++ ++A+ HP+ Sbjct: 286 FPTLFPNANP------DALDLLDRMLAFDPSSRISVEQALEHPYL 324 >4MYG-A nrPDB Length = 372 Score = 121 bits (303), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 89/346 (25%), Positives = 162/346 (46%), Gaps = 62/346 (17%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 K Y VG G Y V + S K+ IK L Sbjct: 43 KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKL-------------------------- 76 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA-------- 149 + PFQ + + ++L H H N+I L D+ TPA Sbjct: 77 SRPFQSEIFAKRAYRELLLL--------KHMQHENVIGLLDVF------TPASSLRNFYD 122 Query: 150 --LVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN 207 LV ++ +I+ + ++ +I++ ++++LK L Y HS G++HRD+KP N+ ++ ++ Sbjct: 123 FYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-ED 181 Query: 208 KKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 +L+++D+GLA H + E V +R+++ PE+++ + Y+ ++D+WS G ++A M+ Sbjct: 182 CELKILDFGLAR--HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTG 239 Query: 268 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREF-YDMDQYIRKPWHRFINDG 326 + F G DQL +I+KV G E ++ K + + + Q RK + + Sbjct: 240 KT-LFKGKDYLDQLTQILKVTGVPGTE-FVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRA 297 Query: 327 NKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK 372 + + DL++ +L D +RLTA +A+ HP+F P R+ E+ Sbjct: 298 SPQAA------DLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEE 337 >4EWQ-A nrPDB Length = 383 Score = 120 bits (302), Expect = 7e-28, Method: Compositional matrix adjust. Identities = 95/368 (25%), Positives = 173/368 (47%), Gaps = 73/368 (19%) Query: 13 TNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML- 71 +N +++R Y N I W + Y+ + VG G Y V + +++ +K L Sbjct: 22 SNASQERPTFYRQELNKTI-WEVPER-YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLS 79 Query: 72 KP----VKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPH 127 +P + K+ RE+++L H Sbjct: 80 RPFQSIIHAKRTYRELRLLK---------------------------------------H 100 Query: 128 NGHANIIHLFDIIKDPISKTPALVFEYVDNV---------DFR--ILYPKLTDLEIRFYM 176 H N+I L D+ TPA E ++V D + KLTD ++F + Sbjct: 101 MKHENVIGLLDVF------TPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLI 154 Query: 177 FELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFF 236 +++L+ L Y HS I+HRD+KP N+ ++ ++ +L+++D+GLA H + E VA+R++ Sbjct: 155 YQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR--HTDDEMTGYVATRWY 211 Query: 237 KGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKY 296 + PE+++++ Y+ ++D+WS G ++A ++ R F GT + DQL I++++GT E Sbjct: 212 RAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRT-LFPGTDHIDQLKLILRLVGTPGAE-L 269 Query: 297 LLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKE 356 L K R + + K +N N + N +DL++ +L D +R+TA + Sbjct: 270 LKKISSESARNYIQSLTQMPK-----MNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQ 324 Query: 357 AMGHPWFA 364 A+ H +FA Sbjct: 325 ALAHAYFA 332 >6GU6-A nrPDB Length = 302 Score = 120 bits (300), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 95/350 (27%), Positives = 168/350 (48%), Gaps = 66/350 (18%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVP 95 + +DY K+G G Y V++G + + +K KI + E VP Sbjct: 5 SMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMK--------------KIRLESEEEGVP 50 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 T + ++ +LK +R H NI+ L D++ L+FE++ Sbjct: 51 STAI----------REISLLKELR----------HPNIVSLQDVLMQ--DSRLYLIFEFL 88 Query: 156 DNVDFRILYPKLTDLE------IRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 ++D + + + ++ Y++++L+ + +CHS ++HRD+KP N++ID K Sbjct: 89 -SMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKG-T 146 Query: 210 LRLIDWGLAEFYHVNME-YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 268 ++L D+GLA + + + Y V + +++ PE+L+ Y +D+WS GT+ A + K+ Sbjct: 147 IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKK 206 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKY-----LLKYEITLPREFYDMDQYIRKPWHRFI 323 P FHG S DQL +I + LGT + E + L Y+ T P+ KP Sbjct: 207 -PLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPK---------WKP----- 251 Query: 324 NDGNKHLSGNDE-IIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK 372 H+ DE +DL+ +L YD +R++ K A+ HP+F + QI+K Sbjct: 252 GSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKK 301 >2BPM-A nrPDB Length = 309 Score = 116 bits (291), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 81/251 (32%), Positives = 133/251 (52%), Gaps = 27/251 (10%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRIL-YPKLTDLE---IRFYMFELLKALDY 185 H NI+ L D+I LVFE++ + + LT + I+ Y+F+LL+ L + Sbjct: 65 HPNIVKLLDVIH--TENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 122 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME-YNVRVASRFFKGPELLVD 244 CHS ++HRD+KP N++I+ + ++L D+GLA + V + Y V + +++ PE+L+ Sbjct: 123 CHSHRVLHRDLKPQNLLINTEG-AIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 181 Query: 245 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 + Y ++D+WS G + A M+ +R F G S DQL +I + LGT D E+ Sbjct: 182 CKYYSTAVDIWSLGCIFAEMVTRRA-LFPGDSEIDQLFRIFRTLGTPD--------EVVW 232 Query: 305 PREFYDMDQYIRKP----WHRFINDGNKHLSGNDE-IIDLIDNLLRYDHQERLTAKEAMG 359 P M Y KP W R D +K + DE L+ +L YD +R++AK A+ Sbjct: 233 P-GVTSMPDY--KPSFPKWAR--QDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALA 287 Query: 360 HPWFAPIREQI 370 HP+F + + + Sbjct: 288 HPFFQDVTKPV 298 >3E3P-A nrPDB Length = 360 Score = 115 bits (287), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 88/333 (26%), Positives = 162/333 (48%), Gaps = 48/333 (14%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIK-REIKILTDLSNEKVPPTT 98 +++E G+G + V G + + + + IK K ++ + + RE++I+ DL+ P Sbjct: 25 FQVERMAGQGTFGTVQLGKEKSTGMSVAIK--KVIQDPRFRNRELQIMQDLAVLHHP--N 80 Query: 99 LPFQKDQYYT----NQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 + + +YT ++++ L + Y+ D H N + ++ P L Sbjct: 81 IVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYY------RRQVAPPPIL---- 130 Query: 155 VDNVDFRILYPKLTDLEIRFYMFELLKALDYCH--SMGIMHRDVKPHNVMIDHKNKKLRL 212 I+ ++F+L++++ H S+ + HRD+KPHNV+++ + L+L Sbjct: 131 -----------------IKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKL 173 Query: 213 IDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFF 272 D+G A+ + + SR+++ PEL+ + Y ++D+WS G + A M+ EP F Sbjct: 174 CDFGSAKKLSPSEPNVAYICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLG-EPIF 232 Query: 273 HGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRK--PWHRFINDGNKHL 330 G ++ QL +IV+VLG E +L+ L D+D Y K PW +D + L Sbjct: 233 RGDNSAGQLHEIVRVLGCPSRE--VLR---KLNPSHTDVDLYNSKGIPWSNVFSDHS--L 285 Query: 331 SGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 E DL+ LL+Y +ER+ EA+ HP+F Sbjct: 286 KDAKEAYDLLSALLQYLPEERMKPYEALCHPYF 318 >5G6V-A nrPDB Length = 324 Score = 113 bits (282), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 73/248 (29%), Positives = 133/248 (53%), Gaps = 17/248 (6%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDL----EIRFYMFELLKALDY 185 HANI+ L DII K+ LVFEY+D D + ++ ++ ++F+LL+ L Y Sbjct: 59 HANIVTLHDIIH--TEKSLTLVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGLAY 115 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME-YNVRVASRFFKGPELLVD 244 CH ++HRD+KP N++I+ + +L+L D+GLA + + Y+ V + +++ P++L+ Sbjct: 116 CHRQKVLHRDLKPQNLLINERG-ELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLG 174 Query: 245 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 Y +D+W G + M R P F G++ +QL I ++LGT E + L Sbjct: 175 STDYSTQIDMWGVGCIFYEMATGR-PLFPGSTVEEQLHFIFRILGTPTEE----TWPGIL 229 Query: 305 PREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 E + Y + ++ + + + DL+ LL+++ + R++A++AM HP+F Sbjct: 230 SNEEFKTYNYPKYRAEALLSHAPRL---DSDGADLLTKLLQFEGRNRISAEDAMKHPFFL 286 Query: 365 PIREQIEK 372 + E+I K Sbjct: 287 SLGERIHK 294 >1CM8-A nrPDB Length = 367 Score = 113 bits (282), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 82/317 (25%), Positives = 161/317 (50%), Gaps = 43/317 (13%) Query: 63 KVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL--PFQKDQYYTNQKEDVLKFIRP 120 +V+ V + L+PV + + KV L PFQ + + + L+ ++ Sbjct: 22 EVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRE-LRLLK- 79 Query: 121 YIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYP-------------KL 167 H H N+I L D+ TP + D DF ++ P KL Sbjct: 80 ------HMRHENVIGLLDVF------TPDETLD--DFTDFYLVMPFMGTDLGKLMKHEKL 125 Query: 168 TDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEY 227 + I+F ++++LK L Y H+ GI+HRD+KP N+ ++ ++ +L+++D+GLA + E Sbjct: 126 GEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVN-EDCELKILDFGLAR--QADSEM 182 Query: 228 NVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKV 287 V +R+++ PE+++++ Y ++D+WS G ++A MI + F G+ + DQL +I+KV Sbjct: 183 TGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKT-LFKGSDHLDQLKEIMKV 241 Query: 288 LGTSDFEKYLLKYEITLPREFY-DMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRY 346 GT E ++ + + + + + + +K + + + + ++L++ +L Sbjct: 242 TGTPPAE-FVQRLQSDEAKNYMKGLPELEKKDFASILTNASPL------AVNLLEKMLVL 294 Query: 347 DHQERLTAKEAMGHPWF 363 D ++R+TA EA+ HP+F Sbjct: 295 DAEQRVTAGEALAHPYF 311 >3GC9-A nrPDB Length = 370 Score = 113 bits (282), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 76/257 (29%), Positives = 132/257 (51%), Gaps = 43/257 (16%) Query: 127 HNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILY----------------PKLTDL 170 H H N+I L D+ TPA E DF +Y L+D Sbjct: 83 HLKHENVIGLLDVF------TPATSIE-----DFSEVYLVTTLMGADLNNIVKSQALSDE 131 Query: 171 EIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVR 230 ++F +++LL+ L Y HS GI+HRD+KP NV ++ ++ +LR++D+GLA + E Sbjct: 132 HVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVN-EDSELRILDFGLAR--QADEEMTGY 188 Query: 231 VASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGT 290 VA+R+++ PE+++++ Y+ ++D+WS G ++A ++ + + F G+ DQL +I++V+GT Sbjct: 189 VATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL-QGKALFPGSDYIDQLKRIMEVVGT 247 Query: 291 SDFE---KYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYD 347 E K ++ T + M Q R N IDL+ +L D Sbjct: 248 PSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFR---------GANPLAIDLLGRMLVLD 298 Query: 348 HQERLTAKEAMGHPWFA 364 +R++A EA+ H +F+ Sbjct: 299 SDQRVSAAEALAHAYFS 315 >5NGU-A nrPDB Length = 381 Score = 112 bits (280), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 82/330 (24%), Positives = 157/330 (47%), Gaps = 59/330 (17%) Query: 46 VGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKK----KIKREIKILTDLSNEKVPPTTLPF 101 +G G Y V +KV++ IK + P + + + REIKIL Sbjct: 50 IGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKIL--------------- 94 Query: 102 QKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI---SKTPALVFEYVDNV 158 L+F H NII + DII+ P K +V + ++ Sbjct: 95 -------------LRF-----------RHENIIGINDIIRAPTIEQMKDVYIVQDLMETD 130 Query: 159 DFRILYPK-LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGL 217 +++L + L++ I ++++++L+ L Y HS ++HRD+KP N++++ L++ D+GL Sbjct: 131 LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGL 189 Query: 218 AEFYHVNMEYNV----RVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFH 273 A + ++ VA+R+++ PE++++ + Y S+D+WS G +LA M+ R P F Sbjct: 190 ARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR-PIFP 248 Query: 274 GTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGN 333 G DQL I+ +LG+ E + + + PW+R + + Sbjct: 249 GKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADS----- 303 Query: 334 DEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + +DL+D +L ++ +R+ ++A+ HP+ Sbjct: 304 -KALDLLDKMLTFNPHKRIEVEQALAHPYL 332 >4BGQ-A nrPDB Length = 304 Score = 109 bits (272), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 79/225 (35%), Positives = 119/225 (52%), Gaps = 17/225 (7%) Query: 150 LVFEYVDNVDFRIL--YPKLTDLE-IRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK 206 LVFEYV+ +L P E ++ Y+++L+KA+ +CH I+HRD+KP N++I H Sbjct: 88 LVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISH- 146 Query: 207 NKKLRLIDWGLAEFYHV--NMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASM 264 N L+L D+G A N Y+ VA+R+++ PELL+ Y S+D+WS G +L + Sbjct: 147 NDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGAP-YGKSVDMWSVGCILGEL 205 Query: 265 IFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIN 324 +P F G S DQL I KVLG E+ L Y + PR F+ + R P Sbjct: 206 -SDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFY--SNPR-FHGL----RFPAVNHPQ 257 Query: 325 DGNKHLSG--NDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIR 367 + G N ++DL+ NLL+ D +R ++ + HP F R Sbjct: 258 SLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQR 302 >3OZ6-A nrPDB Length = 388 Score = 107 bits (268), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 82/365 (22%), Positives = 172/365 (47%), Gaps = 78/365 (21%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML-----KPVKKKKIKREIKILTDLSNE 92 + YE+ K+G+G Y V++ + + + +K + ++ REI ILT+LS Sbjct: 9 RKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELS-- 66 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF 152 GH NI++L ++++ + LVF Sbjct: 67 ------------------------------------GHENIVNLLNVLRADNDRDVYLVF 90 Query: 153 EYVDNVDFRILYPKLTD-LEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 +Y++ ++ + + + ++ +++L+K + Y HS G++HRD+KP N++++ + ++ Sbjct: 91 DYMETDLHAVIRANILEPVHKQYVVYQLIKVIKYLHSGGLLHRDMKPSNILLNAE-CHVK 149 Query: 212 LIDWGLA-EFYHV-----NMEYNVR----------------VASRFFKGPELLVDYRMYD 249 + D+GL+ F ++ N+ ++ VA+R+++ PE+L+ Y Sbjct: 150 VADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQPILTDYVATRWYRAPEILLGSTKYT 209 Query: 250 YSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVL---GTSDFEKY---LLKYEIT 303 +D+WS G +L ++ + P F G+S +QL +I+ V+ D E K I Sbjct: 210 KGIDMWSLGCILGEILCGK-PIFPGSSTMNQLERIIGVIDFPSNEDVESIQSPFAKTMIE 268 Query: 304 LPREFYDMDQYIRK----PWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMG 359 +E ++ Q ++ W + N N+E +DL+D LL+++ +R++A +A+ Sbjct: 269 SLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCNEEALDLLDKLLQFNPNKRISANDALK 328 Query: 360 HPWFA 364 HP+ + Sbjct: 329 HPFVS 333 >4QNY-A nrPDB Length = 354 Score = 106 bits (264), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 61/200 (30%), Positives = 112/200 (56%), Gaps = 11/200 (5%) Query: 166 KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNM 225 +LT+ I+F++++ L+AL HS G++HRD+ P N++++ N L++ D+GLA+ + Sbjct: 121 ELTEAHIQFFIYQALRALHIIHSAGVIHRDITPANILVN-TNCDLKICDFGLAKEENDQG 179 Query: 226 EYNVR-VASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKI 284 EY V R+++ PEL+++ + Y +D+W G +L ++ R P F G +QL KI Sbjct: 180 EYMTDYVTMRWYRAPELVMEDKDYSAQIDVWGIGCILGELLGSR-PLFQGKDRVNQLDKI 238 Query: 285 VKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND-GNKHLSGNDEIIDLIDNL 343 V V+GT E +Y++K HR D ++ + + E +DL+ ++ Sbjct: 239 VDVIGTPSEEDINSVGSSA-------AQKYLKKKSHRPQADWRQRYPTASPEALDLLRHM 291 Query: 344 LRYDHQERLTAKEAMGHPWF 363 L ++ + R+T +AM HP+ Sbjct: 292 LVFNPKRRITVLQAMRHPFL 311 >4QTB-A nrPDB Length = 380 Score = 104 bits (260), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 67/245 (27%), Positives = 129/245 (52%), Gaps = 22/245 (8%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVD---FRIL-YPKLTDLEIRFYMFELLKALDY 185 H N+I + DI++ + V+ D ++ +++L +L++ I ++++++L+ L Y Sbjct: 98 HENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKY 157 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-----EFYHVNM--EYNVRVASRFFKG 238 HS ++HRD+KP N++I+ L++ D+GLA E H EY VA+R+++ Sbjct: 158 IHSANVLHRDLKPSNLLIN-TTCDLKICDFGLARIADPEHDHTGFLTEY---VATRWYRA 213 Query: 239 PELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLL 298 PE++++ + Y S+D+WS G +LA M+ R P F G DQL I+ +LG+ E Sbjct: 214 PEIMLNSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNC 272 Query: 299 KYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAM 358 + + + W + + + +DL+D +L ++ +R+T +EA+ Sbjct: 273 IINMKARNYLQSLPSKTKVAWAKLFP------KSDSKALDLLDRMLTFNPNKRITVEEAL 326 Query: 359 GHPWF 363 HP+ Sbjct: 327 AHPYL 331 >2F9G-A nrPDB Length = 353 Score = 104 bits (260), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 88/348 (25%), Positives = 155/348 (44%), Gaps = 69/348 (19%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKK----KIKREIKILTDLSNE 92 + D+++++ +G G Y V + + IK ++P K + REIKIL Sbjct: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILK----- 64 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPIS----KTP 148 H H NII +F+I + P S Sbjct: 65 ----------------------------------HFKHENIITIFNI-QRPDSFENFNEV 89 Query: 149 ALVFEYVDNVDFRILYPK-LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN 207 ++ E + R++ + L+D I++++++ L+A+ H ++HRD+KP N++I+ N Sbjct: 90 YIIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLIN-SN 148 Query: 208 KKLRLIDWGLAEFYHVNMEYNVR-----------VASRFFKGPELLVDYRMYDYSLDLWS 256 L++ D+GLA + N VA+R+++ PE+++ Y ++D+WS Sbjct: 149 CDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWS 208 Query: 257 FGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFY-DMDQYI 315 G +LA + F R P F G QL+ I ++GT + L E RE+ + Y Sbjct: 209 CGCILAEL-FLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYP 267 Query: 316 RKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 P + N + IDL+ +L +D +R+TAKEA+ HP+ Sbjct: 268 AAPLEKMFP------RVNPKGIDLLQRMLVFDPAKRITAKEALEHPYL 309 >4BBM-A nrPDB Length = 331 Score = 103 bits (256), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 75/244 (30%), Positives = 128/244 (52%), Gaps = 26/244 (10%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDN--VDFRILYPKLTDLEI-RFYMFELLKALDYC 186 H N+++L ++ K K LVFE+VD+ +D L+P D ++ + Y+F+++ + +C Sbjct: 83 HENLVNLLEVCKK--KKRWYLVFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFC 140 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME-YNVRVASRFFKGPELLVDY 245 HS I+HRD+KP N+++ ++ ++L D+G A E Y+ VA+R+++ PELLV Sbjct: 141 HSHNIIHRDIKPENILVS-QSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGD 199 Query: 246 RMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGT------SDFEKYLLK 299 Y ++D+W+ G ++ M F EP F G S+ DQL I+ LG F K + Sbjct: 200 VKYGKAVDVWAIGCLVTEM-FMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVF 258 Query: 300 YEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMG 359 + LP E + R+P R ++ ++ +IDL L D +R E + Sbjct: 259 AGVRLP-EIKE-----REPLER------RYPKLSEVVIDLAKKCLHIDPDKRPFCAELLH 306 Query: 360 HPWF 363 H +F Sbjct: 307 HDFF 310 >4IC8-A nrPDB Length = 442 Score = 101 bits (251), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 70/260 (26%), Positives = 133/260 (51%), Gaps = 41/260 (15%) Query: 127 HNGHANIIHLFDIIKDPIS----KTPALVFEYVDNVDFRILYPK--LTDLEIRFYMFELL 180 H H NII + DI++ + K+ +V + +++ +I++ LT +R+++++LL Sbjct: 110 HFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLL 169 Query: 181 KALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGL--------AEFYHVNMEYNVRVA 232 + L Y HS ++HRD+KP N++++ +N +L++ D+G+ AE + EY VA Sbjct: 170 RGLKYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEY---VA 225 Query: 233 SRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSD 292 +R+++ PEL++ Y ++DLWS G + M+ +R+ F G + QL I+ VLGT Sbjct: 226 TRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQ-LFPGKNYVHQLQLIMMVLGTPS 284 Query: 293 --------FEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLL 344 E+ + PR+ PW ++ + + L+ +L Sbjct: 285 PAVIQAVGAERVRAYIQSLPPRQPV--------PWETVYPGADR------QALSLLGRML 330 Query: 345 RYDHQERLTAKEAMGHPWFA 364 R++ R++A A+ HP+ A Sbjct: 331 RFEPSARISAAAALRHPFLA 350 >6DTL-A nrPDB Length = 364 Score = 101 bits (251), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 69/245 (28%), Positives = 131/245 (53%), Gaps = 20/245 (8%) Query: 127 HNGHANIIHLFDIIKDPISKT---PALVFEYVDNVDFRILYP--KLTDLEIRFYMFELLK 181 H H NI+ + DII P+ + +E +D +I+ L++ +++++++L+ Sbjct: 85 HMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILR 144 Query: 182 ALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPEL 241 L Y HS ++HRD+KP N++++ N L++ D+GLA + V +R+++ PEL Sbjct: 145 GLKYIHSANVLHRDLKPSNLLLN-ANCDLKICDFGLARVTSESDFMTEYVVTRWYRAPEL 203 Query: 242 LVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYE 301 L++ Y ++D+WS G + ++ R+P F G + QL +++++GT E+ E Sbjct: 204 LLNSSDYTAAIDVWSVGCIFMELM-DRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNE 262 Query: 302 ITLPREFYDMDQYIRK--PWHR-FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAM 358 +YIR+ P+ R I D K + + IDLI+ +L +D + R+T +A+ Sbjct: 263 NA--------KRYIRQLPPYPRQSITD--KFPTVHPLAIDLIEKMLTFDPRRRITVLDAL 312 Query: 359 GHPWF 363 HP+ Sbjct: 313 AHPYL 317 >4ZSG-A nrPDB Length = 347 Score = 100 bits (250), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 70/260 (26%), Positives = 133/260 (51%), Gaps = 41/260 (15%) Query: 127 HNGHANIIHLFDIIKDPIS----KTPALVFEYVDNVDFRILYPK--LTDLEIRFYMFELL 180 H H NII + DI++ + K+ +V + +++ +I++ LT +R+++++LL Sbjct: 62 HFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLL 121 Query: 181 KALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGL--------AEFYHVNMEYNVRVA 232 + L Y HS ++HRD+KP N++++ +N +L++ D+G+ AE + EY VA Sbjct: 122 RGLKYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTSPAEHQYFMTEY---VA 177 Query: 233 SRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSD 292 +R+++ PEL++ Y ++DLWS G + M+ +R+ F G + QL I+ VLGT Sbjct: 178 TRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQ-LFPGKNYVHQLQLIMMVLGTPS 236 Query: 293 --------FEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLL 344 E+ + PR+ PW ++ + + L+ +L Sbjct: 237 PAVIQAVGAERVRAYIQSLPPRQ--------PVPWETVYPGADR------QALSLLGRML 282 Query: 345 RYDHQERLTAKEAMGHPWFA 364 R++ R++A A+ HP+ A Sbjct: 283 RFEPSARISAAAALRHPFLA 302 >3GC0-A nrPDB Length = 329 Score = 100 bits (250), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 85/339 (25%), Positives = 154/339 (45%), Gaps = 53/339 (15%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 93 +T+ Y K+G G Y EV++ + + + IK +I + E Sbjct: 30 ATSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIK--------------RIRLEHEEEG 75 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 VP T + ++ +LK ++ H NII L +I + L+FE Sbjct: 76 VPGTAI----------REVSLLKELQ----------HRNIIELKSVIHH--NHRLHLIFE 113 Query: 154 YVDNVDFRILYPKLTDLEIRF---YMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK- 209 Y +N D + K D+ +R ++++L+ +++CHS +HRD+KP N+++ + Sbjct: 114 YAEN-DLKKYMDKNPDVSMRVIKSFLYQLINGVNFCHSRRCLHRDLKPQNLLLSVSDASE 172 Query: 210 ---LRLIDWGLAEFYHVNM-EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 L++ D+GLA + + + ++ + + +++ PE+L+ R Y S+D+WS + A M+ Sbjct: 173 TPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEILLGSRHYSTSVDIWSIACIWAEML 232 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 K P F G S DQL KI +VLG D + LP ++ K R + Sbjct: 233 MK-TPLFPGDSEIDQLFKIFEVLGLPDDTTW--PGVTALPDWKQSFPKFRGKTLKRVLGA 289 Query: 326 GNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + +L D +R++AK A+ HP+F+ Sbjct: 290 LLDDEGLDLLT-----AMLEMDPVKRISAKNALEHPYFS 323 >4AGU-A nrPDB Length = 311 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 91/346 (26%), Positives = 148/346 (42%), Gaps = 74/346 (21%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKML-----KPVKKKKIKREIKILTDLSNEKV 94 YE K+G G Y VF+ D+ + IK PV KK REI++L L Sbjct: 5 YEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLK---- 60 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 H N+++L ++ + + LVFEY Sbjct: 61 -----------------------------------HPNLVNLLEVFRR--KRRLHLVFEY 83 Query: 155 VDNVDFRIL--YPK-LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 D+ L Y + + + ++ ++ L+A+++CH +HRDVKP N++I K+ ++ Sbjct: 84 CDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILIT-KHSVIK 142 Query: 212 LIDWGLAEFYHVNME-YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 L D+G A + Y+ VA+R+++ PELLV Y +D+W+ G + A ++ P Sbjct: 143 LCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELL-SGVP 201 Query: 271 FFHGTSNTDQLVKIVKVLG--------TSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 + G S+ DQL I K LG +Y +I P + ++ +F Sbjct: 202 LWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPEDMEPLEL-------KF 254 Query: 323 INDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 368 N L L+ L D ERLT ++ + HP+F IRE Sbjct: 255 PNISYPALG-------LLKGCLHMDPTERLTCEQLLHHPYFENIRE 293 >2W96-B nrPDB Length = 306 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 71/244 (29%), Positives = 122/244 (50%), Gaps = 26/244 (10%) Query: 130 HANIIHLFDIIKDPISKTP-----ALVFEYVDNVDFRILY-----PKLTDLEIRFYMFEL 179 H N++ L D+ S+T LVFE+VD D R P L I+ M + Sbjct: 65 HPNVVRLMDVCA--TSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQF 121 Query: 180 LKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGP 239 L+ LD+ H+ I+HRD+KP N+++ ++L D+GLA Y M + V + +++ P Sbjct: 122 LRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALDPVVVTLWYRAP 180 Query: 240 ELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLK 299 E+L+ Y +D+WS G + A M F+R+P F G S DQL KI ++G + + Sbjct: 181 EVLLQ-STYATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGLPPEDDW--P 236 Query: 300 YEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMG 359 +++LPR + +P + + + SG L+ +L ++ +R++A A+ Sbjct: 237 RDVSLPRGAFPPRG--PRPVQSVVPEMEE--SGA----QLLLEMLTFNPHKRISAFRALQ 288 Query: 360 HPWF 363 H + Sbjct: 289 HSYL 292 >5EFQ-A nrPDB Length = 347 Score = 98.6 bits (244), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 86/339 (25%), Positives = 152/339 (44%), Gaps = 51/339 (15%) Query: 31 IDWSTNTKD-YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK-----IKREIK 84 IDW D ++I +G G Y +V++ D+ + +K ++ +K+ REIK Sbjct: 3 IDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIK 62 Query: 85 ILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI 144 IL L+++ + + T+ KED L F + Sbjct: 63 ILRQLTHQSI------INMKEIVTD-KEDALDFKKD------------------------ 91 Query: 145 SKTPALVFEYVDNVDFRILYPKLTDLE---IRFYMFELLKALDYCHSMGIMHRDVKPHNV 201 LVFEY+D+ +L L I+ +M +L++ LDYCH +HRD+K N+ Sbjct: 92 KGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNI 151 Query: 202 MIDHKNKKLRLIDWGLAEFYHV--NMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGT 259 +++++ +++L D+GLA Y + Y +V + +++ PELL+ Y ++D+WS G Sbjct: 152 LLNNRG-QIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGC 210 Query: 260 MLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPW 319 +L + F ++P F QL I ++ G+ + ++ QY RK Sbjct: 211 ILGEL-FTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLR 269 Query: 320 HRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAM 358 F+ L DL D +L D +R TA++A+ Sbjct: 270 EEFVFIPAAAL-------DLFDYMLALDPSKRCTAEQAL 301 >3MIA-A nrPDB Length = 351 Score = 97.4 bits (241), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 93/359 (25%), Positives = 159/359 (44%), Gaps = 69/359 (19%) Query: 26 YENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKI 85 Y++ + YE K+G+G + EVF+ + K+ +K K+ Sbjct: 5 YDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALK--------------KV 50 Query: 86 LTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIK---D 142 L + E P T L ++ +L+ ++ H N+++L +I + Sbjct: 51 LMENEKEGFPITAL----------REIKILQLLK----------HENVVNLIEICRTKAS 90 Query: 143 PISKTPA---LVFEYVDNVDFRIL---YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDV 196 P ++ LVF++ ++ +L K T EI+ M LL L Y H I+HRD+ Sbjct: 91 PYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDM 150 Query: 197 KPHNVMIDHKNKKLRLIDWGLAEFYHVNM-----EYNVRVASRFFKGPELLVDYRMYDYS 251 K NV+I ++ L+L D+GLA + + Y RV + +++ PELL+ R Y Sbjct: 151 KAANVLIT-RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGPP 209 Query: 252 LDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDM 311 +DLW G ++A M + R P G + QL I ++ G+ IT P + ++ Sbjct: 210 IDLWGAGCIMAEM-WTRSPIMQGNTEQHQLALISQLCGS-----------IT-PEVWPNV 256 Query: 312 DQY-------IRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 D Y + K R + D K + +DLID LL D +R+ + +A+ H +F Sbjct: 257 DNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFF 315 >3ZDU-A nrPDB Length = 325 Score = 95.5 bits (236), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 67/245 (27%), Positives = 124/245 (50%), Gaps = 26/245 (10%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLE---IRFYMFELLKALDYC 186 H N+++L ++ + K LVFE++D+ L LE +R Y+F++L+A+DY Sbjct: 60 HENLVNLIEVFRQ--KKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQILRAIDYL 117 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME-YNVRVASRFFKGPELLVDY 245 HS I+HRD+KP N+++ ++ +L D+G A + Y+ VA+R+++ PEL++ Sbjct: 118 HSNNIIHRDIKPENILVS-QSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAPELVLKD 176 Query: 246 RMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSD------FEKYLLK 299 Y +D+W+ G M+ M P+ +S+ D L KIV +G F K + Sbjct: 177 TSYGKPVDIWALGCMIIEMA-TGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIF 235 Query: 300 YEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMG 359 + LP+ ++ P N K+ N + D++ L+ D +R+++ + + Sbjct: 236 AGVVLPQ--------VQHPK----NARKKYPKLNGLLADIVHACLQIDPADRISSSDLLH 283 Query: 360 HPWFA 364 H +F Sbjct: 284 HEYFT 288 >3NIE-A nrPDB Length = 429 Score = 95.5 bits (236), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 96/408 (23%), Positives = 176/408 (43%), Gaps = 111/408 (27%) Query: 26 YENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP-----VKKKKIK 80 ++ +I +YEI++ +GRG Y V+ ++ + IK + + K+I Sbjct: 16 FQGAIIKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRIL 75 Query: 81 REIKILTDLSNE---KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLF 137 REI IL L ++ ++ +P ED+LKF YI ++ + Sbjct: 76 REITILNRLKSDYIIRLHDLIIP-----------EDLLKFDELYI----------VLEIA 114 Query: 138 DIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVK 197 D + KTP LT+ ++ ++ LL + H GI+HRD+K Sbjct: 115 DSDLKKLFKTPIF----------------LTEQHVKTILYNLLLGEKFIHESGIIHRDLK 158 Query: 198 PHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNV--------------------------RV 231 P N +++ ++ +++ D+GLA + + + ++ V Sbjct: 159 PANCLLN-QDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPHNKNLKKQLTSHV 217 Query: 232 ASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI----------FKREPFFHGTS----- 276 +R+++ PEL++ Y S+D+WS G + A ++ R P F G+S Sbjct: 218 VTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRFPLFPGSSCFPLS 277 Query: 277 ------------NTDQLVKIVKVLGTSDFE--KYLLKYEITLPREFYDMDQYIRK-PWHR 321 N DQL I V+GT E K + K E+ +YI+ P Sbjct: 278 PDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVI---------KYIKLFPTRD 328 Query: 322 FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 I+ K+ S + E IDL++++LR++ Q+R+T +A+ HP+ +R++ Sbjct: 329 GIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKE 376 >3PG1-A nrPDB Length = 362 Score = 94.7 bits (234), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 80/332 (24%), Positives = 156/332 (46%), Gaps = 43/332 (12%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 Y ++ + G Y V GV + PV IKR ++D T+ Sbjct: 24 YTVQRFISSGSYGAVCAGVDSEGI---------PVA---IKRVFNTVSD-------GRTV 64 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII---KDPISKTPALVFEYVD 156 D + + VL+ IR + + H H NI+ L DI ++P LV E + Sbjct: 65 NILSDSFLCKR---VLREIR--LLNHFH--HPNILGLRDIFVHFEEPAMHKLYLVTELMR 117 Query: 157 NVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLI 213 ++++ + ++ I+++M+ +L L H G++HRD+ P N+++ N + + Sbjct: 118 TDLAQVIHDQRIVISPQHIQYFMYHILLGLHVLHEAGVVHRDLHPGNILLA-DNNDITIC 176 Query: 214 DWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFH 273 D+ LA + V R+++ PEL++ ++ + +D+WS G ++A M F R+ F Sbjct: 177 DFNLAREDTADANKTHYVTHRWYRAPELVMQFKGFTKLVDMWSAGCVMAEM-FNRKALFR 235 Query: 274 GTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFY--DMDQYIRKPWHRFINDGNKHLS 331 G++ +QL KIV+V+GT E ++ + R++ + + W + + Sbjct: 236 GSTFYNQLNKIVEVVGTPKIEDVVM-FSSPSARDYLRNSLSNVPARAWTAVVP------T 288 Query: 332 GNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + +DLI +L ++ Q R++ ++A+ HP+F Sbjct: 289 ADPVALDLIAKMLEFNPQRRISTEQALRHPYF 320 >4O2Z-A nrPDB Length = 377 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 59/204 (28%), Positives = 108/204 (52%), Gaps = 11/204 (5%) Query: 167 LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVN-M 225 L + ++++++++L+ L Y HS + HRD+KP N ++ + + +L++ID+GL+ V Sbjct: 147 LEESHMQYFVYQILRGLKYLHSANVAHRDLKPAN-LVTNISCELKIIDFGLSRSVDVPYS 205 Query: 226 EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIV 285 E V +R+++ PELL++ Y ++D+WS G + A M + R+P F G + DQL I Sbjct: 206 ELTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEM-YNRKPVFPGRNTMDQLRMIA 264 Query: 286 KVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLR 345 + +G + + E D I K + G L+GN E ID + + Sbjct: 265 QHIGKPPASIVEHREALEKLNELPDGSLNIPK-----LVPG---LAGNTEGIDFLSKMWT 316 Query: 346 YDHQERLTAKEAMGHPWFAPIREQ 369 D +R TA + + HP+ A + ++ Sbjct: 317 LDPSKRPTAADMLAHPYLAHLHDE 340 >3RP9-A nrPDB Length = 458 Score = 93.2 bits (230), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 101/406 (24%), Positives = 169/406 (41%), Gaps = 119/406 (29%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGV-KLDSKVKIVIKMLKP----VKKKKIKREIKIL 86 DW + YEI + +G G Y V + KL+ +V + K+L+ + K+I REI IL Sbjct: 48 DWQIPDR-YEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAIL 106 Query: 87 TDLSNE---KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP 143 L+++ KV +P +DV KF Y+ Sbjct: 107 NRLNHDHVVKVLDIVIP-----------KDVEKFDELYV--------------------- 134 Query: 144 ISKTPALVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHN 200 V E D+ DF+ L+ LT+L I+ ++ LL + Y HS GI+HRD+KP N Sbjct: 135 -------VLEIADS-DFKKLFRTPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPAN 186 Query: 201 VMIDHKNKKLRLIDWGLAE-------------------------FYH---VNMEYNVRVA 232 +++ ++ +++ D+GLA F H + + V Sbjct: 187 CLVN-QDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLKRQLTGHVV 245 Query: 233 SRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI----------FKREPFFHGTS------ 276 +R+++ PEL++ Y ++D+WS G + A ++ R P F G+S Sbjct: 246 TRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYHADRGPLFPGSSCFPLSP 305 Query: 277 --------------NTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRK-PWHR 321 N DQL I +LGT E L +E D +YIR P Sbjct: 306 DQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIE-----ALEKE--DAKRYIRIFPKRE 358 Query: 322 FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIR 367 + + + + + I L+ +L ++ +R+T E + HP+F +R Sbjct: 359 GTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEVR 404 >3E7O-A nrPDB Length = 360 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 61/254 (24%), Positives = 125/254 (49%), Gaps = 18/254 (7%) Query: 130 HANIIHLFDIIKDPIS----KTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDY 185 H NII L ++ + + LV E +D ++++ +L + + ++++L + + Sbjct: 80 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKH 139 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDY 245 HS GI+HRD+KP N+++ + L+++D+GLA N V +R+++ PE+++ Sbjct: 140 LHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLARTASTNFMMTPYVVTRYYRAPEVILGM 198 Query: 246 RMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLP 305 Y ++D+WS G ++ ++ K F GT + DQ K+++ LGT E ++ + T+ Sbjct: 199 G-YKENVDIWSVGCIMGELV-KGSVIFQGTDHIDQWNKVIEQLGTPSAE-FMAALQPTVR 255 Query: 306 REFYDMDQYIRKPWHR------FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMG 359 + Y + F ++ + + DL+ +L D +R++ EA+ Sbjct: 256 NYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALR 315 Query: 360 HP----WFAPIREQ 369 HP W+ P + Sbjct: 316 HPYITVWYDPAEAE 329 >2XS0-A nrPDB Length = 386 Score = 90.9 bits (224), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 64/250 (25%), Positives = 125/250 (50%), Gaps = 18/250 (7%) Query: 130 HANIIHLFDIIKDPIS----KTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDY 185 H NII L ++ S + +V E +D +++ +L + + ++++L + + Sbjct: 84 HKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKH 143 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDY 245 HS GI+HRD+KP N+++ + L+++D+GLA + V +R+++ PE+++ Sbjct: 144 LHSAGIIHRDLKPSNIVV-KSDCTLKILDFGLARTAGTSFMMVPFVVTRYYRAPEVILGM 202 Query: 246 RMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLP 305 Y ++D+WS G ++ MI K F GT + DQ K+++ LGT E ++ K + T+ Sbjct: 203 G-YKENVDIWSVGCIMGEMI-KGGVLFPGTDHIDQWNKVIEQLGTPCPE-FMKKLQPTVR 259 Query: 306 REFYDMDQYIRKPWHR------FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMG 359 + +Y + + F D + + DL+ +L D +R++ EA+ Sbjct: 260 TYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQ 319 Query: 360 HP----WFAP 365 HP W+ P Sbjct: 320 HPYINVWYDP 329 >4NST-A nrPDB Length = 351 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 86/342 (25%), Positives = 153/342 (44%), Gaps = 51/342 (14%) Query: 28 NTVIDWSTNTKD-YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK-----IKR 81 T DW D ++I +G G Y +V++ D+ + +K ++ +K+ R Sbjct: 2 QTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIR 61 Query: 82 EIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIK 141 EIKIL L + V N KE V + D K Sbjct: 62 EIKILRQLIHRSV-------------VNMKEIV----------------TDKQDALDFKK 92 Query: 142 DPISKTPALVFEYVDNVDFRILYPKLTDLE---IRFYMFELLKALDYCHSMGIMHRDVKP 198 D LVFEY+D+ +L L I+ +M +L++ L+YCH +HRD+K Sbjct: 93 D--KGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKC 150 Query: 199 HNVMIDHKNKKLRLIDWGLAEFYHV--NMEYNVRVASRFFKGPELLVDYRMYDYSLDLWS 256 N+++++ +++L D+GLA Y+ + Y +V + +++ PELL+ Y ++D+WS Sbjct: 151 SNILLNNSG-QIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWS 209 Query: 257 FGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIR 316 G +L + F ++P F QL I ++ G+ + I LP Y + Sbjct: 210 CGCILGEL-FTKKPIFQANLELAQLELISRLCGSPC--PAVWPDVIKLP---YFNTMKPK 263 Query: 317 KPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAM 358 K + R + + + +DL+D++L D +R TA++ + Sbjct: 264 KQYRRRLREEFSFIPS--AALDLLDHMLTLDPSKRCTAEQTL 303 >3N9X-A nrPDB Length = 432 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 92/389 (23%), Positives = 171/389 (43%), Gaps = 102/389 (26%) Query: 39 DYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP-----VKKKKIKREIKILTDLSNEK 93 +Y I++ +GRG Y V+ +++ + IK + + K+I REI IL L ++ Sbjct: 27 NYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDY 86 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 + Y +D+LKF YI ++ + D + KTP Sbjct: 87 I--------IRLYDLIIPDDLLKFDELYI----------VLEIADSDLKKLFKTPIF--- 125 Query: 154 YVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLI 213 LT+ I+ ++ LL ++ H GI+HRD+KP N +++ ++ +++ Sbjct: 126 -------------LTEEHIKTILYNLLLGENFIHESGIIHRDLKPANCLLN-QDCSVKVC 171 Query: 214 DWGLAEFYHVNMEYNV-----------------------RVASRFFKGPELLVDYRMYDY 250 D+GLA + + N+ V +R+++ PEL++ Y Sbjct: 172 DFGLARTINSEKDTNIVNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTK 231 Query: 251 SLDLWSFGTMLASMI----------FKREPFFHGTS-----------------NTDQLVK 283 S+D+WS G + A ++ R P F G+S N DQL Sbjct: 232 SIDIWSTGCIFAELLNMLQSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNI 291 Query: 284 IVKVLGT--SDFEKYLLKYEITLPREFYDMDQYIRK-PWHRFINDGNKHLSGNDEIIDLI 340 I ++GT D K + K E+ +YI+ P + IN K+ S +D+ I+L+ Sbjct: 292 IFNIIGTPTEDDLKNINKPEVI---------KYIKLFPHRKPINLKQKYPSISDDGINLL 342 Query: 341 DNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 +++L+++ +R+T +A+ HP+ +R++ Sbjct: 343 ESMLKFNPNKRITIDQALDHPYLKDVRKK 371 >4F9B-A nrPDB Length = 361 Score = 88.2 bits (217), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 91/374 (24%), Positives = 159/374 (42%), Gaps = 90/374 (24%) Query: 40 YEIENKVGRGKYSEVFQG---VKLDSKVKIVIKMLKPVKKK-KIKREIKILTDLSNEKVP 95 ++IE+K+G G +S V+ +++ + KI +K L P +I E++ LT Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLT-------- 74 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 +++V+ Y F + N H I Y+ Sbjct: 75 -----------VAGGQDNVMGV--KYCFRK--NDHVVI-----------------AMPYL 102 Query: 156 DNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDW 215 ++ F + L+ E+R YM L KAL H GI+HRDVKP N + + + KK L+D+ Sbjct: 103 EHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDF 162 Query: 216 GLAEFYH-------------------------VNMEYNVRVASRF----FKGPELLVDYR 246 GLA+ H + + +VA R F+ PE+L Sbjct: 163 GLAQGTHDTKIELLKFVQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCP 222 Query: 247 MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSD-------FEKYLLK 299 ++D+WS G + S++ R PF+ + + L +I+ + G+ + F K +L Sbjct: 223 NQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILC 282 Query: 300 YEITLPREFYDMDQYIR---KPWHRFINDGNKH---LSGNDEIID----LIDNLLRYDHQ 349 + ++ + + +R + +D H L G +E+ D L+D LL + Sbjct: 283 SKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPA 342 Query: 350 ERLTAKEAMGHPWF 363 R+TA+EA+ HP+F Sbjct: 343 SRITAEEALLHPFF 356 >5AWM-A nrPDB Length = 394 Score = 85.9 bits (211), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 56/222 (25%), Positives = 112/222 (50%), Gaps = 13/222 (5%) Query: 150 LVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 LV E +D +++ L + + ++++L + + HS GI+HRD+KP N+++ + Sbjct: 126 LVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-ADCT 184 Query: 210 LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 L+++D+GLA V +R+++ PE+++ Y ++D+WS G ++ MI + Sbjct: 185 LKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGMG-YTENVDIWSVGCIMGEMI-RGG 242 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG--- 326 F GT + DQ KI++ LGT ++ + + T+ + +Y + R DG Sbjct: 243 VLFPGTDHIDQWNKIIEQLGTPS-PSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFP 301 Query: 327 -----NKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 N +D +L+ +L D ++R++ EA+ H + Sbjct: 302 NDNNQNSRRKASDA-RNLLSKMLVIDPEQRISVDEALKHEYI 342 >1JNK-A nrPDB Length = 423 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 65/258 (25%), Positives = 124/258 (48%), Gaps = 34/258 (13%) Query: 130 HANIIHLFDIIKDPIS----KTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDY 185 H NII L ++ + + LV E +D +++ +L + + ++++L + + Sbjct: 120 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKH 179 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDY 245 HS GI+HRD+KP N+++ + L+++D+GLA + V +R+++ PE+++ Sbjct: 180 LHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM 238 Query: 246 RMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGT--SDFEKYLL----- 298 Y ++D+WS G ++ M+ + + F G DQ K+++ LGT +F K L Sbjct: 239 G-YKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRN 296 Query: 299 ------KYE-ITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQER 351 KY +T P+ F P F D + + DL+ +L D +R Sbjct: 297 YVENRPKYAGLTFPKLF---------PDSLFPADSEHNKLKASQARDLLSKMLVIDPAKR 347 Query: 352 LTAKEAMGHP----WFAP 365 ++ +A+ HP W+ P Sbjct: 348 ISVDDALQHPYINVWYDP 365 >3FI2-A nrPDB Length = 353 Score = 84.7 bits (208), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 63/252 (25%), Positives = 122/252 (48%), Gaps = 30/252 (11%) Query: 130 HANIIHLFDIIKDPIS----KTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDY 185 H NII L ++ + + LV E +D +++ +L + + ++++L + + Sbjct: 82 HKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKH 141 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDY 245 HS GI+HRD+KP N+++ + L+++D+GLA + V +R+++ PE+++ Sbjct: 142 LHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGM 200 Query: 246 RMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGT--SDFEKYLL----- 298 Y ++D+WS G ++ M+ + + F G DQ K+++ LGT +F K L Sbjct: 201 G-YKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRN 258 Query: 299 ------KYE-ITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQER 351 KY +T P+ F P F D + + DL+ +L D +R Sbjct: 259 YVENRPKYAGLTFPKLF---------PDSLFPADSEHNKLKASQARDLLSKMLVIDPAKR 309 Query: 352 LTAKEAMGHPWF 363 ++ +A+ HP+ Sbjct: 310 ISVDDALQHPYI 321 >4NIF-A nrPDB Length = 333 Score = 84.3 bits (207), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 68/240 (28%), Positives = 113/240 (47%), Gaps = 41/240 (17%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDF--RILYPKL-TDLEIRFYMFELLKALDYC 186 H NII L D+ D K LV E + + +IL K ++ E F + + K ++Y Sbjct: 61 HPNIITLKDVYDD--GKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIGKTVEYL 118 Query: 187 HSMGIMHRDVKPHNVM-IDHKN--KKLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELL 242 HS G++HRD+KP N++ +D + LR+ D+G A + N + F PE+L Sbjct: 119 HSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL 178 Query: 243 VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEI 302 + YD D+WS G +L +M+ PF +G S+T + +I+ +G+ F Sbjct: 179 -KRQGYDEGCDIWSLGILLYTMLAGYTPFANGPSDTPE--EILTRIGSGKFT-------- 227 Query: 303 TLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 ++ GN + + ++ DL+ +L D +RLTAK+ + HPW Sbjct: 228 --------------------LSGGNWN-TVSETAKDLVSKMLHVDPHQRLTAKQVLQHPW 266 >2I6L-A nrPDB Length = 320 Score = 84.0 bits (206), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 61/255 (23%), Positives = 125/255 (49%), Gaps = 31/255 (12%) Query: 130 HANIIHLFDIIKDPISK------------TPALVFEYVDNVDFRIL-YPKLTDLEIRFYM 176 H NI+ +F+I+ S+ + +V EY++ +L L + R +M Sbjct: 67 HDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFM 126 Query: 177 FELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEF----YHVNMEYNVRVA 232 ++LL+ L Y HS ++HRD+KP N+ I+ ++ L++ D+GLA Y + + Sbjct: 127 YQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLV 186 Query: 233 SRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKI---VKVLG 289 +++++ P LL+ Y ++D+W+ G + A M+ + F G +Q+ I + V+ Sbjct: 187 TKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKT-LFAGAHELEQMQLILESIPVVH 245 Query: 290 TSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQ 349 D ++ L + + + + KP + + ++ E +D ++ +L + Sbjct: 246 EEDRQELLSVIPVYIRNDMTEP----HKPLTQLLPGISR------EAVDFLEQILTFSPM 295 Query: 350 ERLTAKEAMGHPWFA 364 +RLTA+EA+ HP+ + Sbjct: 296 DRLTAEEALSHPYMS 310 >6QAU-A nrPDB Length = 280 Score = 84.0 bits (206), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 66/249 (26%), Positives = 111/249 (44%), Gaps = 58/249 (23%) Query: 39 DYEIENKVGRGKYSEVFQG---VKLDSKVKIVIKMLKPVKKKKI--KREIKILTDLSNEK 93 +Y + VG G ++ VF+G K D +V I K + K +I +EIKIL +L Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQ--- 68 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 H NI+ L+D+ + P + LV E Sbjct: 69 ------------------------------------HENIVALYDVQELP--NSVFLVME 90 Query: 154 YV---DNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK-- 208 Y D D+ L++ IR ++ ++ A+ HS GI+HRD+KP N+++ + N+ Sbjct: 91 YCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRK 150 Query: 209 ------KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLA 262 ++++ D+G A + H NM S + PE+++ + YD DLWS GT++ Sbjct: 151 SSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPEVIMS-QHYDAKADLWSIGTVIY 209 Query: 263 SMIFKREPF 271 + + PF Sbjct: 210 QCLVGKPPF 218 >5Y86-A nrPDB Length = 588 Score = 84.0 bits (206), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 59/217 (27%), Positives = 104/217 (47%), Gaps = 29/217 (13%) Query: 172 IRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK-KLRLIDWGLAEFYHVNMEYNVR 230 +R + +L++LD H I+H D+KP N+++ H + ++ID+G + F + + ++ Sbjct: 312 VRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ 371 Query: 231 VASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLG- 289 SRF++ PE+++ R Y +D+WSFG +LA ++ +P F G DQL ++++LG Sbjct: 372 --SRFYRAPEIILGSR-YSTPIDIWSFGCILAELLTG-QPLFPGEDEGDQLACMMELLGM 427 Query: 290 -------TSDFEKYLLKYEITLPREFYDMDQY-------------IRKPWHRFINDGNKH 329 S KY + + +PR Q +K D Sbjct: 428 PPPKLLEQSKRAKYFINSK-GIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTA 486 Query: 330 LSGNDE--IIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 L G D+ I+ + L +D RLT +A+ HPW + Sbjct: 487 LKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 >3Q5I-A nrPDB Length = 504 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 64/248 (25%), Positives = 118/248 (47%), Gaps = 43/248 (17%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFR---ILYPKLTDLEIRFYMFELLKALDYC 186 H NII LFD+ +D K LV E+ + + I K + + M ++L + Y Sbjct: 105 HPNIIKLFDVFEDK--KYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGICYL 162 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKL--RLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVD 244 H I+HRD+KP N+++++KN L +++D+GL+ F+ + + R+ + ++ PE+L Sbjct: 163 HKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAYYIAPEVL-- 220 Query: 245 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 + Y+ D+WS G ++ ++ PF G N ++K ++ Sbjct: 221 KKKYNEKCDVWSCGVIMYILLCGYPPF--GGQNDQDIIK-----------------KVEK 261 Query: 305 PREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + ++D + + K++S DE +LI +L YD+ +R TA+EA+ W Sbjct: 262 GKYYFDFNDW-------------KNIS--DEAKELIKLMLTYDYNKRCTAEEALNSRWIK 306 Query: 365 PIREQIEK 372 I K Sbjct: 307 KYANNINK 314 >3D2K-A nrPDB Length = 272 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 79/338 (23%), Positives = 136/338 (40%), Gaps = 99/338 (29%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML------KPVKKKKIKREIKILTDLSN 91 +D++I +G+GK+ V+ + SK + +K+L K + +++RE++I Sbjct: 12 EDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEI------ 65 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 Q H H NI+ L+ D + L+ Sbjct: 66 ---------------------------------QSHLRHPNILRLYGYFHD--ATRVYLI 90 Query: 152 FEYVDNVDFRILYPKLTDLEIRF-------YMFELLKALDYCHSMGIMHRDVKPHNVMID 204 EY +Y +L L RF Y+ EL AL YCHS ++HRD+KP N+++ Sbjct: 91 LEYAP---LGTVYRELQKLS-RFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLG 146 Query: 205 HKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASM 264 N +L++ D+G + H + P +++ RM+D +DLWS G + Sbjct: 147 -SNGELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEF 203 Query: 265 IFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIN 324 + PF ++T Q + + + + E T P F+ Sbjct: 204 LVGMPPF---EAHTYQ-----------ETYRRISRVEFTFP---------------DFVT 234 Query: 325 DGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 +G + DLI LL+++ +RLT E + HPW Sbjct: 235 EGAR---------DLISRLLKHNASQRLTLAEVLEHPW 263 >3HKO-A nrPDB Length = 345 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 86/369 (23%), Positives = 159/369 (43%), Gaps = 85/369 (23%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSK----VKIV----IKMLKPVKKKKIKREIKILTDL 89 K Y ++ +G+G Y V ++ ++ +KI+ I+ + P ++IK E++++ L Sbjct: 26 KKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKL 85 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHA-NIIHLF----------D 138 + + ++ +QY + + H GH + +++F D Sbjct: 86 HHPNIARLYEVYEDEQYIC------------LVMELCHGGHLLDKLNVFIDDSTGKCAMD 133 Query: 139 IIKDPISKTPAL--------VFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMG 190 ++K I P + + +++DF + KL I M ++ AL Y H+ G Sbjct: 134 VVKTQICPCPECNEEAINGSIHGFRESLDF-VQREKL----ISNIMRQIFSALHYLHNQG 188 Query: 191 IMHRDVKPHNVMID-HKNKKLRLIDWGLA-EFYHV-NMEY---NVRVASRFFKGPELL-V 243 I HRD+KP N + +K+ +++L+D+GL+ EFY + N EY + + +F PE+L Sbjct: 189 ICHRDIKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNT 248 Query: 244 DYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEIT 303 Y D WS G +L ++ P F G ++ D + +++ K L Sbjct: 249 TNESYGPKCDAWSAGVLLHLLLMGAVP-FPGVNDADTISQVLN--------KKLC----- 294 Query: 304 LPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 F + + + P R DL+ NLL + ER A A+ HPW Sbjct: 295 ----FENPNYNVLSPLAR----------------DLLSNLLNRNVDERFDAMRALQHPWI 334 Query: 364 APIREQIEK 372 + ++I K Sbjct: 335 SQFSDKIYK 343 >4MVF-A nrPDB Length = 506 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 85/337 (25%), Positives = 143/337 (42%), Gaps = 79/337 (23%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKR---EIKILTDLSNEKVPP 96 Y I+ K+G+G Y V++G+ + IK K + K I R EI+I+ L + + Sbjct: 59 YIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDHPNIVK 118 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 ++ D Y Y+ + +G LFD I ++ Sbjct: 119 LYETYENDNYI-------------YLIMELCSGR----ELFDSI--------------IE 147 Query: 157 NVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK--LRLID 214 N F T+ M ++ A+ Y HS+ I+HRD+KP N + +NK L++ID Sbjct: 148 NGSF-------TEKNAATIMKQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIID 200 Query: 215 WGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHG 274 +GL++ + + ++ P++L D + YD D+WS G ++ +++ PF+ Sbjct: 201 FGLSKNLGTGEFTTTKAGTPYYVAPQVL-DGK-YDKKCDIWSSGVIMYTLLCGYPPFYGD 258 Query: 275 TSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGND 334 T N +++K VK K E FY+ D W +D Sbjct: 259 TDN--EVLKKVK------------KGEFC----FYEND------WGSISSDAK------- 287 Query: 335 EIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIE 371 +LI LL Y+ ER T +EA+ HPW + + E Sbjct: 288 ---NLITKLLTYNPNERCTIEEALNHPWITQMTKSHE 321 >4UZD-A nrPDB Length = 287 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 77/334 (23%), Positives = 133/334 (39%), Gaps = 91/334 (27%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML------KPVKKKKIKREIKILTDLSN 91 +D+EI +G+GK+ V+ + SK + +K+L K + +++RE++I Sbjct: 8 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEI------ 61 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 Q H H NI+ L+ D + L+ Sbjct: 62 ---------------------------------QSHLRHPNILRLYGYFHD--ATRVYLI 86 Query: 152 FEYVD-NVDFRIL--YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK 208 EY +R L K + Y+ EL AL YCHS ++HRD+KP N+++ Sbjct: 87 LEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAG- 145 Query: 209 KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 268 +L++ D+G + H + P +++ RM+D +DLWS G + + + Sbjct: 146 ELKIADFGWS--VHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGK 203 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 PF +NT Q + K + + E T P F+ +G + Sbjct: 204 PPF---EANTYQ-----------ETYKRISRVEFTFP---------------DFVTEGAR 234 Query: 329 HLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 DLI LL+++ +R +E + HPW Sbjct: 235 ---------DLISRLLKHNPSQRPMLREVLEHPW 259 >3LIJ-A nrPDB Length = 494 Score = 81.3 bits (199), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 65/248 (26%), Positives = 117/248 (47%), Gaps = 46/248 (18%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYC 186 H NI+ L+D +D + LV E D I K +++ + ++L + Y Sbjct: 95 HPNIMKLYDFFEDK--RNYYLVMECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYL 152 Query: 187 HSMGIMHRDVKPHNVMIDHKNKK--LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVD 244 H I+HRD+KP N++++ K K ++++D+GL+ + + R+ + ++ PE+L Sbjct: 153 HKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVL-- 210 Query: 245 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 + YD D+WS G +L ++ P F G ++ + L K+ K KY Sbjct: 211 RKKYDEKCDVWSIGVILF-ILLAGYPPFGGQTDQEILRKVEKG-----------KYTFDS 258 Query: 305 PREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 P W + +++G K DLI +L++D Q R++A++A+ HPW Sbjct: 259 PE------------W-KNVSEGAK---------DLIKQMLQFDSQRRISAQQALEHPW-- 294 Query: 365 PIREQIEK 372 I+E K Sbjct: 295 -IKEMCSK 301 >2X4F-A nrPDB Length = 373 Score = 80.5 bits (197), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 64/240 (26%), Positives = 113/240 (47%), Gaps = 42/240 (17%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDF--RILYPK--LTDLEIRFYMFELLKALDY 185 HAN+I L+D + LV EYVD + RI+ LT+L+ +M ++ + + + Sbjct: 145 HANLIQLYDAFES--KNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIRH 202 Query: 186 CHSMGIMHRDVKPHNVM-IDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVD 244 H M I+H D+KP N++ ++ K++++ID+GLA Y + V + F PE +V+ Sbjct: 203 MHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPE-VVN 261 Query: 245 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 Y + D+WS G + ++ PF G ++ + L I+ ++ L+ E Sbjct: 262 YDFVSFPTDMWSVGVIAYMLLSGLSPFL-GDNDAETLNNILAC-------RWDLEDE--- 310 Query: 305 PREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 EF D+ ++E + I LL + R++A EA+ HPW + Sbjct: 311 --EFQDI---------------------SEEAKEFISKLLIKEKSWRISASEALKHPWLS 347 >4JG6-A nrPDB Length = 355 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 64/241 (26%), Positives = 112/241 (46%), Gaps = 41/241 (17%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDF--RILYPKL-TDLEIRFYMFELLKALDYC 186 H NII L D+ D K +V E + + +IL K ++ E +F + K ++Y Sbjct: 88 HPNIITLKDVYDD--GKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYL 145 Query: 187 HSMGIMHRDVKPHNVM-IDHKN--KKLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELL 242 H+ G++HRD+KP N++ +D + +R+ D+G A + N + F PE+L Sbjct: 146 HAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVL 205 Query: 243 VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEI 302 + + YD + D+WS G +L +M+ PF +G +T + +I+ +G+ F Sbjct: 206 -ERQGYDAACDIWSLGVLLYTMLTGYTPFANGPDDTPE--EILARIGSGKF--------- 253 Query: 303 TLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 +L +++ S +D DL+ +L D +RLTA + HPW Sbjct: 254 SLSGGYWN--------------------SVSDTAKDLVSKMLHVDPHQRLTAALVLRHPW 293 Query: 363 F 363 Sbjct: 294 I 294 >3DXN-A nrPDB Length = 287 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 59/243 (24%), Positives = 113/243 (46%), Gaps = 39/243 (16%) Query: 130 HANIIHLFDIIKDPISKTPAL-VFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHS 188 H NI+ L++ +D + + V+ + D IL K ++++ M ++L Y H Sbjct: 80 HPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHK 139 Query: 189 MGIMHRDVKPHNVMIDHKNKK--LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYR 246 I+HRD+KP N++++ K++ ++++D+GL+ + V + R+ + ++ PE+L + Sbjct: 140 HNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL--RK 197 Query: 247 MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPR 306 YD D+WS G +L ++ PF TDQ +I+K + F Sbjct: 198 KYDEKCDVWSCGVILYILLCGYPPF---GGQTDQ--EILKRVEKGKF------------- 239 Query: 307 EFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPI 366 + W + +DE L+ +L Y+ +R++A+EA+ HPW Sbjct: 240 ------SFDPPDWTQV----------SDEAKQLVKLMLTYEPSKRISAEEALNHPWIVKF 283 Query: 367 REQ 369 Q Sbjct: 284 CSQ 286 >3HZT-A nrPDB Length = 467 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 59/243 (24%), Positives = 113/243 (46%), Gaps = 39/243 (16%) Query: 130 HANIIHLFDIIKDPISKTPAL-VFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHS 188 H NI+ L++ +D + + V+ + D IL K ++++ M ++L Y H Sbjct: 63 HPNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHK 122 Query: 189 MGIMHRDVKPHNVMIDHKNKK--LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYR 246 I+HRD+KP N++++ K++ ++++D+GL+ + V + R+ + ++ PE+L + Sbjct: 123 HNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL--RK 180 Query: 247 MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPR 306 YD D+WS G +L ++ PF TDQ +I+K + F Sbjct: 181 KYDEKCDVWSCGVILYILLCGYPPF---GGQTDQ--EILKRVEKGKF------------- 222 Query: 307 EFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPI 366 + W + +DE L+ +L Y+ +R++A+EA+ HPW Sbjct: 223 ------SFDPPDWTQV----------SDEAKQLVKLMLTYEPSKRISAEEALNHPWIVKF 266 Query: 367 REQ 369 Q Sbjct: 267 CSQ 269 >2YAB-A nrPDB Length = 361 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 66/246 (26%), Positives = 107/246 (43%), Gaps = 43/246 (17%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYC 186 H NII L D+ ++ L+ E V DF L++ E ++ ++L ++Y Sbjct: 74 HPNIITLHDVYENRTD--VVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYL 131 Query: 187 HSMGIMHRDVKPHNVMIDHKN---KKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLV 243 H+ I H D+KP N+M+ KN ++LID+GLA +E+ + F PE+ V Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEI-V 190 Query: 244 DYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEIT 303 +Y D+WS G + ++ PF G + + L I V + DF++ Sbjct: 191 NYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITAV--SYDFDE-------- 239 Query: 304 LPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 EF+ + K D I LL + ++RLT +EA+ HPW Sbjct: 240 ---EFFSQTSELAK--------------------DFIRKLLVKETRKRLTIQEALRHPWI 276 Query: 364 APIREQ 369 P+ Q Sbjct: 277 TPVDTQ 282 >2A27-A nrPDB Length = 321 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 65/246 (26%), Positives = 107/246 (43%), Gaps = 43/246 (17%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYC 186 H N+I L D+ ++ L+ E V DF L++ E ++ ++L ++Y Sbjct: 74 HHNVITLHDVYEN--RTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYL 131 Query: 187 HSMGIMHRDVKPHNVMIDHKN---KKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLV 243 H+ I H D+KP N+M+ KN ++LID+GLA +E+ + F PE +V Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPE-IV 190 Query: 244 DYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEIT 303 +Y D+WS G + ++ PF G + + L I V + DF++ Sbjct: 191 NYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITAV--SYDFDE-------- 239 Query: 304 LPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 EF+ + K D I LL + ++RLT +EA+ HPW Sbjct: 240 ---EFFSQTSELAK--------------------DFIRKLLVKETRKRLTIQEALRHPWI 276 Query: 364 APIREQ 369 P+ Q Sbjct: 277 TPVDNQ 282 >3DFA-A nrPDB Length = 286 Score = 78.2 bits (191), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 63/236 (26%), Positives = 111/236 (47%), Gaps = 39/236 (16%) Query: 130 HANIIHLFDIIKDPIS-KTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHS 188 H NI+ LF+I++D S ++ + D I + ++ + + ++ + Y H Sbjct: 80 HPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHK 139 Query: 189 MGIMHRDVKPHNVMIDHKNK--KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYR 246 I+HRD+KP N++++ K K +++ID+GL+ + N + R+ + ++ PE+L Sbjct: 140 HNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG-- 197 Query: 247 MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPR 306 YD D+WS G +L ++ P F+G + D I+K + T KY LP+ Sbjct: 198 TYDEKCDVWSAGVILY-ILLSGTPPFYGKNEYD----ILKRVETG-------KYAFDLPQ 245 Query: 307 EFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 W R I+D K DLI +L + R+TA + + HPW Sbjct: 246 ------------W-RTISDDAK---------DLIRKMLTFHPSLRITATQCLEHPW 279 >1ZWS-A nrPDB Length = 288 Score = 78.2 bits (191), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 65/246 (26%), Positives = 108/246 (43%), Gaps = 43/246 (17%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYC 186 H N+I L D+ ++ L+ E V DF L++ E ++ ++L ++Y Sbjct: 74 HHNVITLHDVYEN--RTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQILDGVNYL 131 Query: 187 HSMGIMHRDVKPHNVMIDHKN---KKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLV 243 H+ I H D+KP N+M+ KN ++LID+GLA +E+ + F PE +V Sbjct: 132 HTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPE-IV 190 Query: 244 DYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEIT 303 +Y D+WS G + ++ PF G + + L I V + DF++ + Sbjct: 191 NYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANITSV--SYDFDEEFFSHTSE 247 Query: 304 LPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 L ++F IRK LL + ++RLT +EA+ HPW Sbjct: 248 LAKDF------IRK-------------------------LLVKETRKRLTIQEALRHPWI 276 Query: 364 APIREQ 369 P+ Q Sbjct: 277 TPVDNQ 282 >3NCG-A nrPDB Length = 486 Score = 77.8 bits (190), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 64/242 (26%), Positives = 112/242 (46%), Gaps = 51/242 (21%) Query: 130 HANIIHLFDIIKDPIS-------KTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKA 182 H NI+ LF+I++D S T +F+ + I + ++ + + ++ Sbjct: 80 HPNIMKLFEILEDSSSFYIVGELYTGGELFDEI------IKRKRFSEHDAARIIKQVFSG 133 Query: 183 LDYCHSMGIMHRDVKPHNVMIDHKNK--KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPE 240 + Y H I+HRD+KP N++++ K K +++ID+GL+ + N + R+ + ++ PE Sbjct: 134 ITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPE 193 Query: 241 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 300 +L YD D+WS G +L ++ P F+G + D I+K + T KY Sbjct: 194 VL--RGTYDEKCDVWSAGVILY-ILLSGTPPFYGKNEYD----ILKRVETG-------KY 239 Query: 301 EITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGH 360 LP+ W R I+D K DLI +L + R+TA + + H Sbjct: 240 AFDLPQ------------W-RTISDDAK---------DLIRKMLTFHPSLRITATQCLEH 277 Query: 361 PW 362 PW Sbjct: 278 PW 279 >2Y7J-A nrPDB Length = 365 Score = 77.4 bits (189), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 83/374 (22%), Positives = 166/374 (44%), Gaps = 79/374 (21%) Query: 5 VWSEARVYTNINKQRTEEYW----DYENTVIDWSTNT---KDYEIENKVGRGKYSEVFQG 57 + +EA+ + + TE + E+ + DW+ + Y+ ++ +GRG S V + Sbjct: 54 LLAEAKKLNDAQPKGTENLYFQSMGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRC 113 Query: 58 VKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKF 117 V + + +K++ +++ E++ P L ++ + T ++ +L+ Sbjct: 114 VHRATGHEFAVKIM----------------EVTAERLSPEQL--EEVREATRRETHILRQ 155 Query: 118 IRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV---DNVDFRILYPKLTDLEIRF 174 + GH +II L D + S LVF+ + + D+ L++ E R Sbjct: 156 V---------AGHPHIITLIDSYES--SSFMFLVFDLMRKGELFDYLTEKVALSEKETRS 204 Query: 175 YMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASR 234 M LL+A+ + H+ I+HRD+KP N+++D N ++RL D+G + + + Sbjct: 205 IMRSLLEAVSFLHANNIVHRDLKPENILLD-DNMQIRLSDFGFSCHLEPGEKLRELCGTP 263 Query: 235 FFKGPELL-----VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLG 289 + PE+L + Y +DLW+ G +L +++ PF+H Q++ + ++ Sbjct: 264 GYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWH----RRQILMLRMIME 319 Query: 290 TSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQ 349 +Y+ + P E+ D ++ DLI LL+ D + Sbjct: 320 G--------QYQFSSP-EWDDRSSTVK---------------------DLISRLLQVDPE 349 Query: 350 ERLTAKEAMGHPWF 363 RLTA++A+ HP+F Sbjct: 350 ARLTAEQALQHPFF 363 >2QNJ-A nrPDB Length = 328 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 59/252 (23%), Positives = 122/252 (48%), Gaps = 21/252 (8%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYC 186 H NI+ LF++I+ KT L+ EY D+ + + ++ + E R +++ A+ YC Sbjct: 70 HPNIVKLFEVIE--TEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYC 127 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYR 246 H I+HRD+K N+++D + +++ D+G + + V + + S + PEL + Sbjct: 128 HQKRIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKK 186 Query: 247 MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVK------VLGTSDFEKYLLKY 300 +D+WS G +L +++ P F G + + ++++ ++D E L ++ Sbjct: 187 YDGPEVDVWSLGVILYTLVSGSLP-FDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRF 245 Query: 301 EITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGH 360 + P + ++Q ++ W IN G++ DE+ ++ L Q+R+ MG+ Sbjct: 246 LVLNPIKRGTLEQIMKDRW---INAGHEE----DELKPFVEPELDISDQKRIDIMVGMGY 298 Query: 361 PWFAPIREQIEK 372 I+E + K Sbjct: 299 SQ-EEIQESLSK 309 >4YNZ-A nrPDB Length = 342 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 64/255 (25%), Positives = 112/255 (43%), Gaps = 52/255 (20%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKK-----KIKREIKILTDLSNEKV 94 Y +E +G+G+ V G+ + K+ IK++ K K++REI IL Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILK------- 64 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 + + PH ++ L D+ ++ K LV E+ Sbjct: 65 ---------------------------LIEHPH-----VLKLHDVYEN--KKYLYLVLEH 90 Query: 155 VDN---VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 V D+ + +LT E R + +++ ALD+CHS I HRD+KP N+++D +N +R Sbjct: 91 VSGGELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDERN-NIR 149 Query: 212 LIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 + D+G+A + S + PE++ + D+WS G +L +++ PF Sbjct: 150 IADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPF 209 Query: 272 FHGTSNTDQLVKIVK 286 N QL++ VK Sbjct: 210 --DDDNLRQLLEKVK 222 >5ZTN-A nrPDB Length = 429 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 76/358 (21%), Positives = 149/358 (41%), Gaps = 78/358 (21%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK--KKIKREIKILTDLSNEKVPPT 97 YE+ +G+G + +V + + +KM++ K+ ++ EI+IL L + Sbjct: 99 YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQ----- 153 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFD--IIKDPISKTPALV---- 151 K++ + N+IH+ + ++ I T L+ Sbjct: 154 ------------DKDNTM----------------NVIHMLENFTFRNHICMTFELLSMNL 185 Query: 152 FEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK-L 210 +E + F+ L +R + +L+ LD H I+H D+KP N+++ + + + Sbjct: 186 YELIKKNKFQGFSLPL----VRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGI 241 Query: 211 RLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 ++ID+G + + H + + SRF++ PE+++ R Y +D+WS G +LA ++ P Sbjct: 242 KVIDFGSSCYEHQRV--YTYIQSRFYRAPEVILGAR-YGMPIDMWSLGCILAELLTGY-P 297 Query: 271 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 330 G DQL ++++LG +K L + + F Y R ++DG+ L Sbjct: 298 LLPGEDEGDQLACMIELLGMPS-QKLLDASKRA--KNFVSSKGYPRYCTVTTLSDGSVVL 354 Query: 331 SGNDE-------------------------IIDLIDNLLRYDHQERLTAKEAMGHPWF 363 +G +D + L +D R+T +A+ HPW Sbjct: 355 NGGRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL 412 >5YV8-A nrPDB Length = 298 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 44/149 (29%), Positives = 82/149 (55%), Gaps = 8/149 (5%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYC 186 H N++ L +++ DP +VFE V+ ++ L P L++ + RFY +L+K ++Y Sbjct: 95 HPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKP-LSEDQARFYFQDLIKGIEYL 153 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDY 245 H I+HRD+KP N+++ ++ +++ D+G++ EF + + V + F PE L + Sbjct: 154 HYQKIIHRDIKPSNLLVG-EDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSET 212 Query: 246 R--MYDYSLDLWSFGTMLASMIFKREPFF 272 R +LD+W+ G L +F + PF Sbjct: 213 RKIFSGKALDVWAMGVTLYCFVFGQCPFM 241 >6CMJ-A nrPDB Length = 321 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 44/149 (29%), Positives = 82/149 (55%), Gaps = 8/149 (5%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYC 186 H N++ L +++ DP +VFE V+ ++ L P L++ + RFY +L+K ++Y Sbjct: 101 HPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKP-LSEDQARFYFQDLIKGIEYL 159 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDY 245 H I+HRD+KP N+++ ++ +++ D+G++ EF + + V + F PE L + Sbjct: 160 HYQKIIHRDIKPSNLLVG-EDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSET 218 Query: 246 R--MYDYSLDLWSFGTMLASMIFKREPFF 272 R +LD+W+ G L +F + PF Sbjct: 219 RKIFSGKALDVWAMGVTLYCFVFGQCPFM 247 >3F3Z-A nrPDB Length = 277 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 80/329 (24%), Positives = 140/329 (42%), Gaps = 79/329 (24%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 Y +EN +GRG + EV KI ++ K +I+R K K+P Sbjct: 11 YTLENTIGRGSWGEV----------KIAVQ-----KGTRIRRAAK--------KIPKY-- 45 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVD 159 F +D Q+ +++K + H NII L++ +D + LV E + Sbjct: 46 -FVEDVDRFKQEIEIMKSL----------DHPNIIRLYETFED--NTDIYLVMELCTGGE 92 Query: 160 F--RILYPKL-TDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI--DHKNKKLRLID 214 R+++ ++ + + M ++L A+ YCH + + HRD+KP N + D + L+LID Sbjct: 93 LFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLID 152 Query: 215 WGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHG 274 +GLA + +V + ++ P++L +Y D WS G M+ ++ PF Sbjct: 153 FGLAARFKPGKMMRTKVGTPYYVSPQVLEG--LYGPECDEWSAGVMMYVLLCGYPPF--- 207 Query: 275 TSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGND 334 ++ TD V + GT F + K W L+ + Sbjct: 208 SAPTDSEVMLKIREGTFTFPE---------------------KDW----------LNVSP 236 Query: 335 EIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + LI LL ++R+T+ +A+ H WF Sbjct: 237 QAESLIRRLLTKSPKQRITSLQALEHEWF 265 >2HAK-A nrPDB Length = 328 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 53/252 (21%), Positives = 111/252 (44%), Gaps = 50/252 (19%) Query: 28 NTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKM-----LKPVKKKKIKRE 82 + D + +Y ++ +G+G +++V + + ++ +K+ L P +K+ RE Sbjct: 5 TSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFRE 64 Query: 83 IKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD 142 ++I+ L+ H NI+ LF++I+ Sbjct: 65 VRIMKILN---------------------------------------HPNIVKLFEVIE- 84 Query: 143 PISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPH 199 KT LV EY D+ + + ++ + E R +++ A+ YCH I+HRD+K Sbjct: 85 -TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAE 143 Query: 200 NVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGT 259 N+++D + +++ D+G + + V + + S + PEL + +D+WS G Sbjct: 144 NLLLD-GDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGV 202 Query: 260 MLASMIFKREPF 271 +L +++ PF Sbjct: 203 ILYTLVSGSLPF 214 >4RC3-A nrPDB Length = 289 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 57/238 (23%), Positives = 106/238 (44%), Gaps = 35/238 (14%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 Y++ +G G + V+ G+++ + + IK ++ K I +L N T + Sbjct: 14 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVE-------KDRISDWGELPNG----TRV 62 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNV- 158 P + + + +G + +I L D + P S L+ E + V Sbjct: 63 PMEV-----------------VLLKKVSSGFSGVIRLLDWFERPDSFV--LILERPEPVQ 103 Query: 159 ---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDW 215 DF L + R + +++L+A+ +CH+ G++HRD+K N++ID +L+LID+ Sbjct: 104 DLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDF 163 Query: 216 GLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFH 273 G + Y +R + PE + +R + S +WS G +L M+ PF H Sbjct: 164 GSGALLK-DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH 220 >4WNO-A nrPDB Length = 287 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 43/153 (28%), Positives = 78/153 (50%), Gaps = 14/153 (9%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYV---DNVDFRILYPKLTDLEIRFYMFELLKALDYC 186 H NI+ L+D ++ + LV EY D D+ L++ IR ++ ++ A+ Sbjct: 76 HENIVALYDF--QEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLL 133 Query: 187 HSMGIMHRDVKPHNVMIDH--------KNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKG 238 HS GI+HRD+KP N+++ + + ++++ D+G A + NM S + Sbjct: 134 HSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMA 193 Query: 239 PELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 PE+++ + YD DLWS GT++ + + PF Sbjct: 194 PEVIMS-QHYDGKADLWSIGTIVYQCLTGKAPF 225 >5TUR-A nrPDB Length = 404 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 57/238 (23%), Positives = 106/238 (44%), Gaps = 35/238 (14%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 Y++ +G G + V+ G+++ + + IK ++ K I +L N T + Sbjct: 129 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVE-------KDRISDWGELPNG----TRV 177 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNV- 158 P + + + +G + +I L D + P S L+ E + V Sbjct: 178 PMEV-----------------VLLKKVSSGFSGVIRLLDWFERPDSFV--LILERPEPVQ 218 Query: 159 ---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDW 215 DF L + R + +++L+A+ +CH+ G++HRD+K N++ID +L+LID+ Sbjct: 219 DLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDF 278 Query: 216 GLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFH 273 G + Y +R + PE + +R + S +WS G +L M+ PF H Sbjct: 279 GSGALLK-DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH 335 >3BGP-A nrPDB Length = 333 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 57/238 (23%), Positives = 106/238 (44%), Gaps = 35/238 (14%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 Y++ +G G + V+ G+++ + + IK ++ K I +L N T + Sbjct: 58 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVE-------KDRISDWGELPNG----TRV 106 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNV- 158 P + + + +G + +I L D + P S L+ E + V Sbjct: 107 PMEV-----------------VLLKKVSSGFSGVIRLLDWFERPDSFV--LILERPEPVQ 147 Query: 159 ---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDW 215 DF L + R + +++L+A+ +CH+ G++HRD+K N++ID +L+LID+ Sbjct: 148 DLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDF 207 Query: 216 GLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFH 273 G + Y +R + PE + +R + S +WS G +L M+ PF H Sbjct: 208 GSGALLK-DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH 264 >5WAX-A nrPDB Length = 310 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 60/238 (25%), Positives = 99/238 (41%), Gaps = 38/238 (15%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDF--RIL-YPKLTDLEIRFYMFELLKALDYC 186 H NII ++I P A+V EY + RI + ++ E RF+ +L+ + YC Sbjct: 66 HPNIIRFKEVILTPTHL--AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 123 Query: 187 HSMGIMHRDVKPHNVMIDHKNK-KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDY 245 HSM + HRD+K N ++D +L++ D+G ++ ++ + V + + PE+L+ Sbjct: 124 HSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK 183 Query: 246 RMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLP 305 D+WS G L M+ PF + I ++LG Sbjct: 184 EYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQ-------------- 229 Query: 306 REFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 Y + Y+ H+S E DLI + + R+T E HPWF Sbjct: 230 ---YSIPDYV-------------HIS--PECQDLISRIFVANPATRITIPEIRNHPWF 269 >5UNP-A nrPDB Length = 369 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 89/380 (23%), Positives = 168/380 (44%), Gaps = 89/380 (23%) Query: 30 VIDWSTNTKDYEIENKVGRGKYSEVFQGV-KLDSKVKIVIKMLKPVKKKK--IKREIKIL 86 V DW + YEI + +G G + V Q V ++ +K++K V+K K + EI +L Sbjct: 28 VGDWLQ--ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVL 85 Query: 87 TDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQ-PHNGHANI------IHLFDI 139 + NEK P K + +FD ++GH I + FD Sbjct: 86 EKI-NEKDPDN------------------KNLCVQMFDWFDYHGHMCISFELLGLSTFDF 126 Query: 140 IKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPH 199 +KD + + YP ++R F+L +A+ + H + H D+KP Sbjct: 127 LKD----------------NNYLPYPIH---QVRHMAFQLCQAVKFLHDNKLTHTDLKPE 167 Query: 200 NVMIDH------------------KNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPEL 241 N++ + K+ +R++D+G A F H + ++ V++R ++ PE+ Sbjct: 168 NILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEH--HSTIVSTRHYRAPEV 225 Query: 242 LVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLG--------TSDF 293 +++ + D+WS G ++ + F N + L + ++LG + Sbjct: 226 ILEL-GWSQPCDVWSIGCIIFEY-YVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRK 283 Query: 294 EKYLLKYEITLPREFYDMDQYIR---KPWHRFI-NDGNKHLSGNDEIIDLIDNLLRYDHQ 349 +KY + + E +Y+R KP R++ ++ +H ++ DLI+++L Y+ Sbjct: 284 QKYFYRGRLDWD-ENTSAGRYVRENCKPLRRYLTSEAEEH----HQLFDLIESMLEYEPA 338 Query: 350 ERLTAKEAMGHPWFAPIREQ 369 +RLT EA+ HP+FA +R + Sbjct: 339 KRLTLGEALQHPFFARLRAE 358 >5KZ7-A nrPDB Length = 346 Score = 74.3 bits (181), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 62/252 (24%), Positives = 119/252 (47%), Gaps = 27/252 (10%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYC 186 H NI+ LF++I+ KT LV EY D+ + + ++ + E R +++ A+ YC Sbjct: 91 HPNIVKLFEVIE--TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYC 148 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYR 246 H I+HRD+K N+++D + +++ D+G + + + + S + PEL + Sbjct: 149 HQKFIVHRDLKAENLLLD-ADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKK 207 Query: 247 MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIV-------KVLGTSDFEKYLLK 299 +D+WS G +L +++ PF N +L + V ++D E L K Sbjct: 208 YDGPEVDVWSLGVILYTLVSGSLPF--DGQNLKELRERVLRGKYRIPFYMSTDCENLLKK 265 Query: 300 YEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMG 359 + I P + ++Q ++ W +N G++ +DE+ ++ L Y R +MG Sbjct: 266 FLILNPSKRGTLEQIMKDRW---MNVGHE----DDELKPYVEPLPDYKDPRRTELMVSMG 318 Query: 360 HPWFAPIREQIE 371 + RE+I+ Sbjct: 319 Y-----TREEIQ 325 >6C9D-A nrPDB Length = 459 Score = 74.3 bits (181), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 53/251 (21%), Positives = 111/251 (44%), Gaps = 50/251 (19%) Query: 29 TVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKM-----LKPVKKKKIKREI 83 + D + +Y ++ +G+G +++V + + ++ +K+ L P +K+ RE+ Sbjct: 12 SATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREV 71 Query: 84 KILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP 143 +I+ L+ H NI+ LF++I+ Sbjct: 72 RIMKILN---------------------------------------HPNIVKLFEVIE-- 90 Query: 144 ISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHN 200 KT LV EY D+ + + ++ + E R +++ A+ YCH I+HRD+K N Sbjct: 91 TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAEN 150 Query: 201 VMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTM 260 +++D + +++ D+G + + V + + S + PEL + +D+WS G + Sbjct: 151 LLLDG-DMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKYDGPEVDVWSLGVI 209 Query: 261 LASMIFKREPF 271 L +++ PF Sbjct: 210 LYTLVSGSLPF 220 >3MN3-A nrPDB Length = 271 Score = 74.3 bits (181), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 44/145 (30%), Positives = 77/145 (53%), Gaps = 7/145 (4%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDN--VDFRILYPKLTDLEIRFYMFELLKALDYCH 187 H +II L+D+IK +V EY N D+ + K+++ E R + +++ A++YCH Sbjct: 63 HPHIIKLYDVIKS--KDEIIMVIEYAGNELFDYIVQRDKMSEQEARRFFQQIISAVEYCH 120 Query: 188 SMGIMHRDVKPHNVMID-HKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYR 246 I+HRD+KP N+++D H N +++ D+GL+ S + PE++ Sbjct: 121 RHKIVHRDLKPENLLLDEHLN--VKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKL 178 Query: 247 MYDYSLDLWSFGTMLASMIFKREPF 271 +D+WS G +L M+ +R PF Sbjct: 179 YAGPEVDVWSCGVILYVMLCRRLPF 203 >5JN2-A nrPDB Length = 525 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 60/245 (24%), Positives = 114/245 (46%), Gaps = 40/245 (16%) Query: 130 HANIIHLFDIIKD-PISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHS 188 H NI+ L++ +D V+ + D I + ++++ + ++L + Y H Sbjct: 126 HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK 185 Query: 189 MGIMHRDVKPHNVMIDHKNK--KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYR 246 I+HRD+KP N++++ K+K +R+ID+GL+ + + + ++ + ++ PE+L + Sbjct: 186 NKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVL--HG 243 Query: 247 MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPR 306 YD D+WS G +L ++ P F+G + D L K+ K KY LP+ Sbjct: 244 TYDEKCDVWSTGVILY-ILLSGCPPFNGANEYDILKKVEKG-----------KYTFELPQ 291 Query: 307 EFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP- 365 W + ++ DLI +L Y R++A++A+ H W Sbjct: 292 ------------WKKV----------SESAKDLIRKMLTYVPSMRISARDALDHEWIQTY 329 Query: 366 IREQI 370 +EQI Sbjct: 330 TKEQI 334 >3TAC-A nrPDB Length = 361 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 64/227 (28%), Positives = 100/227 (44%), Gaps = 52/227 (22%) Query: 150 LVFEYVDNVDFRILYPKLTDLEIRF-------YMFELLKALDYCHSMGIMHRDVKPHNVM 202 +VFE++D D K D + YM ++L+AL YCH I+HRDVKPH V+ Sbjct: 105 MVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVL 164 Query: 203 IDHK--NKKLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGT 259 + K + ++L +G+A + + RV + F PE +V Y +D+W G Sbjct: 165 LASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPE-VVKREPYGKPVDVWGCGV 223 Query: 260 MLASMIFKREPFFHGTSNTDQLVKIVKVLGTSD--FEKYL-LKYEITLPREFYDMDQYIR 316 +L ++ PF+ GT + FE + KY++ PR+ Sbjct: 224 ILFILLSGCLPFY----------------GTKERLFEGIIKGKYKMN-PRQ--------- 257 Query: 317 KPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 W H+S + DL+ +L D ER+T EA+ HPW Sbjct: 258 --W--------SHIS--ESAKDLVRRMLMLDPAERITVYEALNHPWL 292 >5ES1-A nrPDB Length = 328 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 48/198 (24%), Positives = 96/198 (48%), Gaps = 11/198 (5%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYC 186 H NI+ LF++I+ KT LV EY D+ + + ++ + E R +++ A+ YC Sbjct: 73 HPNIVKLFEVIE--TEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYC 130 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYR 246 H I+HRD+K N+++D + +++ D+G + + + + + S + PEL + Sbjct: 131 HQKNIVHRDLKAENLLLDAE-ANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKK 189 Query: 247 MYDYSLDLWSFGTMLASMIFKREPF-FHGTSNTDQLVK----IVKVLGTSDFEKYLLKYE 301 +D+WS G +L +++ PF H + V V ++D E L ++ Sbjct: 190 YDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFL 249 Query: 302 ITLPREFYDMDQYIRKPW 319 + P + ++Q ++ W Sbjct: 250 VLNPAKRCTLEQIMKDKW 267 >4B8L-A nrPDB Length = 286 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 80/331 (24%), Positives = 138/331 (41%), Gaps = 87/331 (26%) Query: 39 DYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTT 98 D++I +G+GK+ V+ + +K + +K+L K ++ Sbjct: 16 DFDIGRPLGKGKFGNVYLAREKQNKFIMALKVL-------FKSQL--------------- 53 Query: 99 LPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNV 158 +KE V +R I Q H H NI+ +++ D K L+ E+ Sbjct: 54 -----------EKEGVEHQLRREIEIQSHLRHPNILRMYNYFHD--RKRIYLMLEFAPRG 100 Query: 159 DFRILYPKLTDLEIRF-------YMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 + LY +L RF +M EL AL YCH ++HRD+KP N+++ +K +L+ Sbjct: 101 E---LYKELQK-HGRFDEQRSATFMEELADALHYCHERKVIHRDIKPENLLMGYKG-ELK 155 Query: 212 LIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 + D+G + + ++ + + PE +++ + +D +DLW G + + P Sbjct: 156 IADFGWS-VHAPSLRRRTMCGTLDYLPPE-MIEGKTHDEKVDLWCAGVLCYEFLVGMPP- 212 Query: 272 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLS 331 F S+T+ +IV V ++ P F++DG+K Sbjct: 213 FDSPSHTETHRRIVNV-------------DLKFP---------------PFLSDGSK--- 241 Query: 332 GNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 DLI LLRY +RL K M HPW Sbjct: 242 ------DLISKLLRYHPPQRLPLKGVMEHPW 266 >3MA6-A nrPDB Length = 298 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 57/236 (24%), Positives = 110/236 (46%), Gaps = 39/236 (16%) Query: 130 HANIIHLFDIIKD-PISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHS 188 H NI+ L++ +D V+ + D I + ++++ + ++L + Y H Sbjct: 91 HPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHK 150 Query: 189 MGIMHRDVKPHNVMIDHKNK--KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYR 246 I+HRD+KP N++++ K+K +R+ID+GL+ + + + ++ + ++ PE+L + Sbjct: 151 NKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVL--HG 208 Query: 247 MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPR 306 YD D+WS G +L ++ P F+G + D L K+ K KY LP+ Sbjct: 209 TYDEKCDVWSTGVILY-ILLSGCPPFNGANEYDILKKVEKG-----------KYTFELPQ 256 Query: 307 EFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 W + ++ DLI +L Y R++A++A+ H W Sbjct: 257 ------------WKKV----------SESAKDLIRKMLTYVPSMRISARDALDHEW 290 >3KN6-A nrPDB Length = 325 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 55/173 (31%), Positives = 89/173 (51%), Gaps = 11/173 (6%) Query: 129 GHANIIHLFDIIKDPISKTPALVFEYVDNVDF--RILYPK-LTDLEIRFYMFELLKALDY 185 GH NI+ L ++ D + LV E ++ + RI K ++ E + M +L+ A+ + Sbjct: 64 GHPNIVKLHEVFHDQLHTF--LVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSH 121 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKL--RLIDWGLAEFYHV-NMEYNVRVASRFFKGPELL 242 H +G++HRD+KP N++ +N L ++ID+G A N + + PELL Sbjct: 122 MHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPELL 181 Query: 243 VDYRMYDYSLDLWSFGTMLASMIFKREPF-FHGTSNT-DQLVKIVKVLGTSDF 293 + YD S DLWS G +L +M+ + PF H S T V+I+K + DF Sbjct: 182 -NQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDF 233 >6FDY-U nrPDB Length = 276 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 81/330 (24%), Positives = 130/330 (39%), Gaps = 85/330 (25%) Query: 42 IENKVGRGKYSEVFQG-VKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLP 100 + ++G G Y+ V++ K D++ + IK + K E +LT++ Sbjct: 15 LTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVE-NLLTEI----------- 62 Query: 101 FQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDF 160 ++LK IR H +I+ L D D S L+ E+ D Sbjct: 63 ------------EILKGIR----------HPHIVQLKDFQWD--SDNIYLIMEFCAGGDL 98 Query: 161 -------RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK-LRL 212 RIL K+ R +M +L AL + H I H D+KP N+++ K L+L Sbjct: 99 SRFIHTRRILPEKVA----RVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKL 154 Query: 213 IDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFF 272 D+G A+ E +V S + PE++ R YD +DLWS G +L +F + PF Sbjct: 155 ADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQ-RQYDARVDLWSMGVILYEALFGQPPFA 213 Query: 273 HGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSG 332 R F ++++ IR +R I + L Sbjct: 214 S--------------------------------RSFSELEEKIRS--NRVIELPLRPLLS 239 Query: 333 NDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 D DL+ LL D R++ ++ HPW Sbjct: 240 RD-CRDLLQRLLERDPSRRISFQDFFAHPW 268 >2WO6-A nrPDB Length = 382 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 62/254 (24%), Positives = 127/254 (50%), Gaps = 38/254 (14%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKI-LTDLSNEKVPPTT 98 YEI++ +G+G + +V + + + IK++K K + +I++ L +L N Sbjct: 56 YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMN------- 108 Query: 99 LPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNV 158 ++ T K ++ R ++F ++ +F+++ + ++ + N Sbjct: 109 ------KHDTEMKYYIVHLKRHFMFRN------HLCLVFEMLSYNL-------YDLLRNT 149 Query: 159 DFRILYPKLTDLEIRFYMFELLKALDYCHS--MGIMHRDVKPHNVMI-DHKNKKLRLIDW 215 +FR + LT R + ++ AL + + + I+H D+KP N+++ + K ++++D+ Sbjct: 150 NFRGVSLNLT----RKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDF 205 Query: 216 GLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGT 275 G + + + SRF++ PE+L+ YD ++D+WS G +L M EP F G Sbjct: 206 GSS--CQLGQRIYQYIQSRFYRSPEVLLGMP-YDLAIDMWSLGCILVEM-HTGEPLFSGA 261 Query: 276 SNTDQLVKIVKVLG 289 + DQ+ KIV+VLG Sbjct: 262 NEVDQMNKIVEVLG 275 >2W4O-A nrPDB Length = 349 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 76/329 (23%), Positives = 135/329 (41%), Gaps = 81/329 (24%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK-PVKKKKIKREIKILTDLSNEKVPPTT 98 +E+E+++GRG S V++ + ++ +K+LK V KK ++ EI +L LS Sbjct: 55 FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLS-------- 106 Query: 99 LPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNV 158 H NII L +I + P + LV E V Sbjct: 107 -------------------------------HPNIIKLKEIFETPTEIS--LVLELVTGG 133 Query: 159 DF--RILYPKL-TDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM--IDHKNKKLRLI 213 + RI+ ++ + + ++L+A+ Y H GI+HRD+KP N++ + L++ Sbjct: 134 ELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIA 193 Query: 214 DWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFH 273 D+GL++ + + + PE+L Y +D+WS G + ++ EPF+ Sbjct: 194 DFGLSKIVEHQVLMKTVCGTPGYCAPEILRGC-AYGPEVDMWSVGIITYILLCGFEPFYD 252 Query: 274 GTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGN 333 DQ + R + + Y PW ++ K Sbjct: 253 --ERGDQF----------------------MFRRILNCEYYFISPWWDEVSLNAK----- 283 Query: 334 DEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 DL+ L+ D ++RLT +A+ HPW Sbjct: 284 ----DLVRKLIVLDPKKRLTTFQALQHPW 308 >2J90-A nrPDB Length = 304 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 65/247 (26%), Positives = 102/247 (41%), Gaps = 45/247 (18%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYC 186 H NII L DI ++ L+ E V DF LT+ E ++ ++L + Y Sbjct: 88 HPNIITLHDIFENKTD--VVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYL 145 Query: 187 HSMGIMHRDVKPHNVMIDHKN---KKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLV 243 HS I H D+KP N+M+ KN +++LID+G+A E+ + F PE+ V Sbjct: 146 HSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEI-V 204 Query: 244 DYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEIT 303 +Y D+WS G + ++ PF G + + L I V Sbjct: 205 NYEPLGLEADMWSIGVITYILLSGASPFL-GETKQETLTNISAV---------------- 247 Query: 304 LPREFYDMDQYIRKPWHRFINDGNKHLSGNDEII-DLIDNLLRYDHQERLTAKEAMGHPW 362 YD D+ ++ S E+ D I LL D + R+T +++ H W Sbjct: 248 ----NYDFDE--------------EYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSW 289 Query: 363 FAPIREQ 369 IR + Sbjct: 290 IKAIRRR 296 >4CFF-A nrPDB Length = 571 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 43/146 (29%), Positives = 73/146 (50%), Gaps = 8/146 (5%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYC 186 H +II L+ +I P +V EYV D+ + ++ ++E R ++L A+DYC Sbjct: 92 HPHIIKLYQVISTPTDFF--MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 149 Query: 187 HSMGIMHRDVKPHNVMID-HKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDY 245 H ++HRD+KP NV++D H N K + D+GL+ S + PE++ Sbjct: 150 HRHMVVHRDLKPENVLLDAHMNAK--IADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 207 Query: 246 RMYDYSLDLWSFGTMLASMIFKREPF 271 +D+WS G +L +++ PF Sbjct: 208 LYAGPEVDIWSCGVILYALLCGTLPF 233 >5EZV-A nrPDB Length = 560 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 43/146 (29%), Positives = 73/146 (50%), Gaps = 8/146 (5%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYC 186 H +II L+ +I P +V EYV D+ + ++ ++E R ++L A+DYC Sbjct: 87 HPHIIKLYQVISTPTDFF--MVMEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYC 144 Query: 187 HSMGIMHRDVKPHNVMID-HKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDY 245 H ++HRD+KP NV++D H N K + D+GL+ S + PE++ Sbjct: 145 HRHMVVHRDLKPENVLLDAHMNAK--IADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGR 202 Query: 246 RMYDYSLDLWSFGTMLASMIFKREPF 271 +D+WS G +L +++ PF Sbjct: 203 LYAGPEVDIWSCGVILYALLCGTLPF 228 >1NY3-A nrPDB Length = 400 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 55/200 (27%), Positives = 87/200 (43%), Gaps = 37/200 (18%) Query: 168 TDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK--NKKLRLIDWGLAEFYHVNM 225 T+ E M + +A+ Y HS+ I HRDVKP N++ K N L+L D+G A+ + Sbjct: 159 TEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN 218 Query: 226 EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFF--HGTSNTDQLVK 283 + ++ PE+L + YD S D+WS G ++ ++ PF+ HG + + Sbjct: 219 SLTTPCYTPYYVAPEVLGPEK-YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISP---- 273 Query: 284 IVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNL 343 M IR + F N +S +E+ LI NL Sbjct: 274 --------------------------GMKTRIRMGQYEFPNPEWSEVS--EEVKMLIRNL 305 Query: 344 LRYDHQERLTAKEAMGHPWF 363 L+ + +R+T E M HPW Sbjct: 306 LKTEPTQRMTITEFMNHPWI 325 >3H4J-B nrPDB Length = 336 Score = 72.0 bits (175), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 42/144 (29%), Positives = 74/144 (51%), Gaps = 5/144 (3%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDN--VDFRILYPKLTDLEIRFYMFELLKALDYCH 187 H +II L+D+I P +V EY D+ + ++T+ E R + +++ A++YCH Sbjct: 68 HPHIIKLYDVITTPTDIV--MVIEYAGGELFDYIVEKKRMTEDEGRRFFQQIICAIEYCH 125 Query: 188 SMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRM 247 I+HRD+KP N+++D N +++ D+GL+ S + PE++ Sbjct: 126 RHKIVHRDLKPENLLLD-DNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLY 184 Query: 248 YDYSLDLWSFGTMLASMIFKREPF 271 +D+WS G +L M+ R PF Sbjct: 185 AGPEVDVWSCGIVLYVMLVGRLPF 208 >2OZA-A nrPDB Length = 356 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 55/200 (27%), Positives = 87/200 (43%), Gaps = 37/200 (18%) Query: 168 TDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK--NKKLRLIDWGLAEFYHVNM 225 T+ E M + +A+ Y HS+ I HRDVKP N++ K N L+L D+G A+ + Sbjct: 115 TEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN 174 Query: 226 EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFF--HGTSNTDQLVK 283 + ++ PE+L + YD S D+WS G ++ ++ PF+ HG + + Sbjct: 175 SLTTPCYTPYYVAPEVLGPEK-YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISP---- 229 Query: 284 IVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNL 343 M IR + F N +S +E+ LI NL Sbjct: 230 --------------------------GMKTRIRMGQYEFPNPEWSEVS--EEVKMLIRNL 261 Query: 344 LRYDHQERLTAKEAMGHPWF 363 L+ + +R+T E M HPW Sbjct: 262 LKTEPTQRMTITEFMNHPWI 281 >5D9K-A nrPDB Length = 330 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 64/262 (24%), Positives = 116/262 (44%), Gaps = 37/262 (14%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKV 94 + +E+ +G+G + +VF K+ + +K +KK +K ++ T + + + Sbjct: 27 ADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDIL 86 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 PF +Y Q E L I ++ + L Sbjct: 87 VEVNHPFIVKLHYAFQTEGKLYLILDFL-----------------------RGGDLFTRL 123 Query: 155 VDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLID 214 V F T+ +++FY+ EL ALD+ HS+GI++RD+KP N+++D + ++L D Sbjct: 124 SKEVMF-------TEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEG-HIKLTD 175 Query: 215 WGLAE--FYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFF 272 +GL++ H Y+ + + PE +V+ R + S D WSFG ++ M+ P F Sbjct: 176 FGLSKESIDHEKKAYSF-CGTVEYMAPE-VVNRRGHTQSADWWSFGVLMFEMLTGTLP-F 232 Query: 273 HGTSNTDQLVKIVKV-LGTSDF 293 G + + I+K LG F Sbjct: 233 QGKDRKETMTMILKAKLGMPQF 254 >6CKI-A nrPDB Length = 316 Score = 71.6 bits (174), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 54/208 (25%), Positives = 94/208 (45%), Gaps = 33/208 (15%) Query: 169 DLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK--KLRLIDWGLAEFYHVNME 226 +LE + ++ ALD+ H+ GI HRD+KP N++ +H N+ +++ D+GL +N + Sbjct: 110 ELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGD 169 Query: 227 YN--------VRVASRFFKGPELLVDY----RMYDYSLDLWSFGTMLASMIFKREPFFHG 274 + S + PE++ + +YD DLWS G +L ++ PF G Sbjct: 170 CSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFV-G 228 Query: 275 TSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGND 334 +D G E P + + I++ + F + H+S Sbjct: 229 RCGSD--------CGWDRGE--------ACPACQNMLFESIQEGKYEFPDKDWAHISCAA 272 Query: 335 EIIDLIDNLLRYDHQERLTAKEAMGHPW 362 + DLI LL D ++RL+A + + HPW Sbjct: 273 K--DLISKLLVRDAKQRLSAAQVLQHPW 298 >5YKS-A nrPDB Length = 377 Score = 71.6 bits (174), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 60/241 (24%), Positives = 105/241 (43%), Gaps = 44/241 (18%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK----LTDLEIRFYMFELLKALDY 185 H NI+ L+++I D +K L+ E D D K L + + Y +++ A+ Y Sbjct: 93 HPNIVRLYEVI-DTQTKL-YLILELGDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISY 150 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDY 245 CH + ++HRD+KP NV+ K ++L D+G + + + S + PE+L+ Sbjct: 151 CHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGD 210 Query: 246 RMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLP 305 ++D+WS G +L M+ +P F ++++ L I+ KY T+P Sbjct: 211 EYDAPAVDIWSLGVILF-MLVCGQPPFQEANDSETLTMIMDC-------KY------TVP 256 Query: 306 REFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 H+S E DLI +L+ D + R + +E HPW Sbjct: 257 ----------------------SHVS--KECKDLITRMLQRDPKRRASLEEIENHPWLQG 292 Query: 366 I 366 + Sbjct: 293 V 293 >4X7Q-B nrPDB Length = 312 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 53/245 (21%), Positives = 104/245 (42%), Gaps = 47/245 (19%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 +Y + +G+G + VF G +L ++++ IK++ + + + LS+ Sbjct: 31 AEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIP-------RNRVLGWSPLSDS----V 79 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFD----------IIKDPISKT 147 T P + + GH +I L D +++ P+ Sbjct: 80 TCPLEVALLWKVGA---------------GGGHPGVIRLLDWFETQEGFMLVLERPL--- 121 Query: 148 PAL-VFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK 206 PA +F+Y+ L + R + +++ A+ +CHS G++HRD+K N++ID + Sbjct: 122 PAQDLFDYITEKG------PLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLR 175 Query: 207 NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 +LID+G H + Y +R + PE + ++ + +WS G +L M+ Sbjct: 176 RGCAKLIDFGSGALLH-DEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVC 234 Query: 267 KREPF 271 PF Sbjct: 235 GDIPF 239 >4CQG-A nrPDB Length = 331 Score = 71.2 bits (173), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 56/205 (27%), Positives = 95/205 (46%), Gaps = 23/205 (11%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYC 186 H +I L+ +++ +V EY D+ I +L++ E R ++L A+ Y Sbjct: 66 HQHICQLYHVLE--TKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYV 123 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVR--VASRFFKGPELLVD 244 HS G HRD+KP N++ D +N KL+LID+GL N +Y+++ S + PEL+ Sbjct: 124 HSQGYAHRDLKPENLLFD-ENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQG 182 Query: 245 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFE--KYLLKYEI 302 D+WS G +L ++ PF + D ++ + K + +E K+L I Sbjct: 183 KSYLGSEADVWSMGILLYVLMCGFLPF-----DDDNVMALYKKIMRGKYEVPKWLSPSSI 237 Query: 303 TL--------PREFYDMDQYIRKPW 319 L P++ M + PW Sbjct: 238 LLLQQMLQVDPKKRISMRNLLNHPW 262 >4RGJ-A nrPDB Length = 520 Score = 70.9 bits (172), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 48/189 (25%), Positives = 92/189 (48%), Gaps = 39/189 (20%) Query: 178 ELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK---LRLIDWGLAEFYHVNMEYNVRVASR 234 ++L + Y H ++HRD+KP N++++ KNK+ +++ID+GL+ + + + ++ + Sbjct: 168 QILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKIGTA 227 Query: 235 FFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFE 294 ++ P++L + YD D+WS G +L ++ P F+G++ D L K+ Sbjct: 228 YYIAPDVL--HGTYDEKCDIWSCGVILY-ILLSGCPPFNGSNEYDILKKVEAG------- 277 Query: 295 KYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTA 354 KY LP+ + I+D K DLI +L Y R++A Sbjct: 278 ----KYTFDLPQ-------------FKKISDKAK---------DLIKKMLMYTSAVRISA 311 Query: 355 KEAMGHPWF 363 ++A+ H W Sbjct: 312 RDALEHEWI 320 >4CRL-A nrPDB Length = 406 Score = 70.9 bits (172), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 54/212 (25%), Positives = 108/212 (50%), Gaps = 24/212 (11%) Query: 172 IRFYMFELLKALDYCHSMGIMHRDVKPHNVMI---DHKNKKLRLIDWGLAEFYHVNM--- 225 ++ ++++L + Y H+ ++HRD+KP N+++ + ++++ D G A ++ + Sbjct: 131 VKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPL 190 Query: 226 -EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHG------TSNT 278 + + V + +++ PELL+ R Y ++D+W+ G + A ++ EP FH TSN Sbjct: 191 ADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELL-TSEPIFHCRQEDIKTSNP 249 Query: 279 ---DQLVKIVKVLG-TSDFEKYLLKYEITLPREFYDMDQYIRKPW--HRFINDGNKH-LS 331 DQL +I V+G +D + +K +P M + R + I KH + Sbjct: 250 YHHDQLDRIFNVMGFPADKDWEDIK---KMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVK 306 Query: 332 GNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + + L+ LL D +R+T+++AM P+F Sbjct: 307 PDSKAFHLLQKLLTMDPIKRITSEQAMQDPYF 338 >4D2V-A nrPDB Length = 356 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 55/203 (27%), Positives = 95/203 (46%), Gaps = 19/203 (9%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYC 186 H +I L+ +++ + +V EY D+ I +L++ E R +++ A+ Y Sbjct: 86 HQHICQLYHVLE--TANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYV 143 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVR--VASRFFKGPELLVD 244 HS G HRD+KP N++ D + KL+LID+GL N +Y+++ + + PEL+ Sbjct: 144 HSQGYAHRDLKPENLLFDEYH-KLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQG 202 Query: 245 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 D+WS G +L ++ PF T+ + KI++ G D K+L I L Sbjct: 203 KSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAA-LVAKIMR--GKYDVPKWLSPSSILL 259 Query: 305 --------PREFYDMDQYIRKPW 319 P++ M + PW Sbjct: 260 LQQMLQVDPKKRISMKNLLNHPW 282 >3KA0-A nrPDB Length = 320 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 55/200 (27%), Positives = 87/200 (43%), Gaps = 37/200 (18%) Query: 168 TDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK--NKKLRLIDWGLAEFYHVNM 225 T+ E M + +A+ Y HS+ I HRDVKP N++ K N L+L D+G A+ + Sbjct: 113 TEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHN 172 Query: 226 EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFF--HGTSNTDQLVK 283 + ++ PE+L + YD S D+WS G ++ ++ PF+ HG + + Sbjct: 173 SLTEPCYTPYYVAPEVLGPEK-YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISP---- 227 Query: 284 IVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNL 343 M IR + F N +S +E+ LI NL Sbjct: 228 --------------------------GMKTRIRMGQYEFPNPEWSEVS--EEVKMLIRNL 259 Query: 344 LRYDHQERLTAKEAMGHPWF 363 L+ + +R+T E M HPW Sbjct: 260 LKTEPTQRMTITEFMNHPWI 279 >4D28-A nrPDB Length = 446 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 63/243 (25%), Positives = 109/243 (44%), Gaps = 54/243 (22%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKM------LKPVKKKKIKREIKILTDLSNEK 93 YE+ +G G +++V D+ + IK+ LK +IKREI I+ Sbjct: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIM------- 63 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA-LVF 152 K +R H NI+ L++++ SK+ +V Sbjct: 64 ----------------------KIVR----------HPNIVRLYEVLA---SKSKIYIVL 88 Query: 153 EYVDNVDF--RILY-PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 E+V + RI++ +L + E R Y +L+ A+ +CHS G+ HRD+KP N+++D N Sbjct: 89 EFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCHSKGVYHRDLKPENLLLD-TNGN 147 Query: 210 LRLIDWGLAEFYHVNME-YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 268 L++ D+GL+ +E N + + PE+L + D+WS G +L ++ Sbjct: 148 LKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGY 207 Query: 269 EPF 271 PF Sbjct: 208 LPF 210 >3RAW-A nrPDB Length = 381 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 85/360 (23%), Positives = 162/360 (45%), Gaps = 73/360 (20%) Query: 40 YEIENKVGRGKYSEVFQGV-KLDSKVKIVIKMLKPVKK--KKIKREIKILTDLSNEKVPP 96 YEI +G G + +V + + K ++ +K+++ V K + + EI +L + Sbjct: 53 YEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIK------ 106 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 +KD KE+ KF+ + D N H ++ F+++ FE++ Sbjct: 107 -----EKD------KEN--KFLCVLMSDW-FNFHGHMCIAFELLGKN-------TFEFLK 145 Query: 157 NVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI----------DHK 206 +F+ YP +R ++L AL + H + H D+KP N++ +HK Sbjct: 146 ENNFQP-YPLP---HVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHK 201 Query: 207 --------NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFG 258 N +R+ D+G A F H + + VA+R ++ PE++++ + D+WS G Sbjct: 202 SCEEKSVKNTSIRVADFGSATFDHEH--HTTIVATRHYRPPEVILELG-WAQPCDVWSIG 258 Query: 259 TMLASMIFKREPFFHGTSNTDQLVKIVKVLGT--------SDFEKYLLKYEITLPREFYD 310 +L ++ F N + LV + K+LG + +KY K + D Sbjct: 259 CILFEY-YRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSD 317 Query: 311 MDQYIR---KPWHRF-INDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPI 366 +Y++ KP + + D +H+ ++ DL+ +L +D +R+T EA+ HP+FA + Sbjct: 318 -GRYVKENCKPLKSYMLQDSLEHV----QLFDLMRRMLEFDPAQRITLAEALLHPFFAGL 372 >5XZW-A nrPDB Length = 471 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 65/231 (28%), Positives = 100/231 (43%), Gaps = 52/231 (22%) Query: 150 LVFEYV---DNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK 206 +V E+V D +DF + + + R ++L A+ Y HSMGI HRD+KP N++I+ Sbjct: 271 MVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQD 330 Query: 207 NKKL-RLIDWGLAE------FYHVNMEYNVRVASRFFKGPELLVDYRMY----DYS--LD 253 + L ++ D+GLA+ F VA +G + V Y +YS +D Sbjct: 331 DPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVD 390 Query: 254 LWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQ 313 +WS G ++ ++ PF S DQL K Q Sbjct: 391 MWSMGCLVYVILTGHLPF--SGSTQDQLYK-----------------------------Q 419 Query: 314 YIRKPWHRFINDGN-KHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 R +H +G K ++E D ID+LL+ D R TA +A+ HPW Sbjct: 420 IGRGSYH----EGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWI 466 >1KOB-A nrPDB Length = 387 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 65/247 (26%), Positives = 108/247 (43%), Gaps = 44/247 (17%) Query: 122 IFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDF--RILYP--KLTDLEIRFYMF 177 I +Q H H +I+L D +D L+ E++ + RI K+++ E+ YM Sbjct: 101 IMNQLH--HPKLINLHDAFEDKYEMV--LILEFLSGGELFDRIAAEDYKMSEAEVINYMR 156 Query: 178 ELLKALDYCHSMGIMHRDVKPHNVMID-HKNKKLRLIDWGLAEFYHVNMEYNVRVASRFF 236 + + L + H I+H D+KP N+M + K +++ID+GLA + + V A+ F Sbjct: 157 QACEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEF 216 Query: 237 KGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKY 296 PE +VD + D+W+ G + ++ PF G D E Sbjct: 217 AAPE-IVDREPVGFYTDMWAIGVLGYVLLSGLSPF----------------AGEDDLE-- 257 Query: 297 LLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKE 356 TL Q +++ F D +S E D I NLL+ + ++RLT + Sbjct: 258 ------TL--------QNVKRCDWEFDEDAFSSVS--PEAKDFIKNLLQKEPRKRLTVHD 301 Query: 357 AMGHPWF 363 A+ HPW Sbjct: 302 ALEHPWL 308 >4CZT-A nrPDB Length = 464 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 48/150 (32%), Positives = 81/150 (54%), Gaps = 13/150 (8%) Query: 130 HANIIHLFDIIKDPISKTPA-LVFEYVDNVDF--RILY-PKLTDLEIRFYMFELLKALDY 185 H N+I +F+++ SKT V E+V + +I +L + E R Y +L+ A+DY Sbjct: 70 HPNVIRMFEVM---ASKTKIYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDY 126 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME---YNVRVASRFFKGPELL 242 CHS G+ HRD+KP N+++D N L++ D+GL+ E + + + PE + Sbjct: 127 CHSRGVYHRDLKPENLLLDA-NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE-V 184 Query: 243 VDYRMYDYS-LDLWSFGTMLASMIFKREPF 271 ++ + YD + DLWS G +L ++ PF Sbjct: 185 INNKGYDGAKADLWSCGVILFVLMAGYLPF 214 >2YZA-A nrPDB Length = 276 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 62/220 (28%), Positives = 101/220 (45%), Gaps = 14/220 (6%) Query: 57 GVKLDSKVKIVIKMLKPVKKKKIKREIKILT-DLSNEKVPPTTLPFQKDQYYTNQKEDVL 115 G K D +VKI +L ++KI L+ KV L QK + DV+ Sbjct: 1 GSKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSL-----DVV 55 Query: 116 KFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTDLEI 172 I+ I + H +II L+ +I P +V EYV D+ + ++ ++E Sbjct: 56 GKIKREIQNLKLFRHPHIIKLYQVISTPTDFF--MVMEYVSGGELFDYICKHGRVEEMEA 113 Query: 173 RFYMFELLKALDYCHSMGIMHRDVKPHNVMID-HKNKKLRLIDWGLAEFYHVNMEYNVRV 231 R ++L A+DYCH ++HRD+KP NV++D H N K+ D+GL+ Sbjct: 114 RRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIA--DFGLSNMMSDGEFLRDSC 171 Query: 232 ASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 S + PE++ +D+WS G +L +++ PF Sbjct: 172 GSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF 211 >6E9W-A nrPDB Length = 443 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 76/261 (29%), Positives = 113/261 (43%), Gaps = 51/261 (19%) Query: 23 YWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKI-VIKMLKPVKKKKIKR 81 Y D N + D +DYE+ +GRG + EV Q V+ S K+ +K+L K + IKR Sbjct: 87 YKDTINKIRDLRMKAEDYEVVKVIGRGAFGEV-QLVRHKSTRKVYAMKLLS--KFEMIKR 143 Query: 82 EIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIR-PYIFDQPHNGHANIIHLFDII 140 D + ++ D++ F P++ + LF Sbjct: 144 ---------------------SDSAFFWEERDIMAFANSPWV-----------VQLFYAF 171 Query: 141 KDPISKTPALVFEYVDNVDFRILYPKLTDLE--IRFYMFELLKALDYCHSMGIMHRDVKP 198 +D + +V EY+ D L E RFY E++ ALD HSMG +HRDVKP Sbjct: 172 QD--DRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKP 229 Query: 199 HNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVR----VASRFFKGPELLVDY---RMYDYS 251 N+++D K+ L+L D+G +N E VR V + + PE+L Y Sbjct: 230 DNMLLD-KSGHLKLADFGTC--MKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRE 286 Query: 252 LDLWSFGTMLASMIFKREPFF 272 D WS G L M+ PF+ Sbjct: 287 CDWWSVGVFLYEMLVGDTPFY 307 >2WQN-A nrPDB Length = 310 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 66/273 (24%), Positives = 112/273 (41%), Gaps = 64/273 (23%) Query: 32 DWSTNT-KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIK------MLKPVKKKKIKREIK 84 D NT ++ IE K+GRG++SEV++ L V + +K ++ + +EI Sbjct: 25 DMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEID 84 Query: 85 ILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI 144 +L L++ +V+K+ +I D N Sbjct: 85 LLKQLNHP--------------------NVIKYYASFIEDNELN---------------- 108 Query: 145 SKTPALVFEYVDNVDF----------RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHR 194 +V E D D + L P+ T + Y +L AL++ HS +MHR Sbjct: 109 -----IVLELADAGDLSRMIKHFKKQKRLIPERT---VWKYFVQLCSALEHMHSRRVMHR 160 Query: 195 DVKPHNVMIDHKNKKLRLIDWGLAEFYHV-NMEYNVRVASRFFKGPELLVDYRMYDYSLD 253 D+KP NV I ++L D GL F+ + V + ++ PE + + Y++ D Sbjct: 161 DIKPANVFIT-ATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHE-NGYNFKSD 218 Query: 254 LWSFGTMLASMIFKREPFFHGTSNTDQLVKIVK 286 +WS G +L M + PF+ N L K ++ Sbjct: 219 IWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIE 251 >3HDN-A nrPDB Length = 373 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 65/248 (26%), Positives = 108/248 (43%), Gaps = 42/248 (16%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 D+ +G+G + +V +V +K+L+ K K E I+++ N + Sbjct: 38 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSE-RNVLLKNV 96 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 PF +++ Q D L F+ YI NG HL Sbjct: 97 KHPFLVGLHFSFQTADKLYFVLDYI-----NGGELFYHL--------------------Q 131 Query: 158 VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGL 217 + L P+ RFY E+ AL Y HS+ I++RD+KP N+++D + + L D+GL Sbjct: 132 RERCFLEPR-----ARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQG-HIVLTDFGL 185 Query: 218 AEFYHVNMEYNVRVASRFFKGPELLVDYRM----YDYSLDLWSFGTMLASMIFKREPFFH 273 + N+E+N S F PE L + YD ++D W G +L M++ PF+ Sbjct: 186 CK---ENIEHN-STTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFY- 240 Query: 274 GTSNTDQL 281 + NT ++ Sbjct: 241 -SRNTAEM 247 >4YZB-A nrPDB Length = 491 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 48/188 (25%), Positives = 89/188 (47%), Gaps = 38/188 (20%) Query: 178 ELLKALDYCHSMGIMHRDVKPHNVMIDHKNK--KLRLIDWGLAEFYHVNMEYNVRVASRF 235 ++L + Y H I+HRD+KP N+++++K K +R+ID+GL+ + + ++ + + Sbjct: 138 QVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAY 197 Query: 236 FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEK 295 + PE+L + YD D+WS G +L ++ P F+G + D L K+ K Sbjct: 198 YIAPEVL--HGTYDEKCDVWSTGVIL-YILLSGCPPFNGANEFDILKKVEKG-------- 246 Query: 296 YLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAK 355 K+ LP+ W + ++ DLI +L Y R++A+ Sbjct: 247 ---KFTFDLPQ------------WKKV----------SEPAKDLIRKMLAYVPTMRISAR 281 Query: 356 EAMGHPWF 363 +A+ H W Sbjct: 282 DALEHEWL 289 >3UC3-A nrPDB Length = 361 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 42/146 (28%), Positives = 72/146 (49%), Gaps = 6/146 (4%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDF--RIL-YPKLTDLEIRFYMFELLKALDYC 186 H NI+ ++I P A++ EY + RI + ++ E RF+ +LL + YC Sbjct: 75 HPNIVRFKEVILTPTHL--AIIMEYASGGELYERICNAGRFSEDEARFFFQQLLSGVSYC 132 Query: 187 HSMGIMHRDVKPHNVMIDHK-NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDY 245 HSM I HRD+K N ++D +L++ D+G ++ ++ + V + + PE+L+ Sbjct: 133 HSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQ 192 Query: 246 RMYDYSLDLWSFGTMLASMIFKREPF 271 D+WS G L M+ PF Sbjct: 193 EYDGKIADVWSCGVTLYVMLVGAYPF 218 >1FOT-A nrPDB Length = 318 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 62/245 (25%), Positives = 113/245 (46%), Gaps = 52/245 (21%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYC 186 H II ++ +D ++ ++ +Y++ + L K + +FY E+ AL+Y Sbjct: 65 HPFIIRMWGTFQD--AQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYL 122 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYR 246 HS I++RD+KP N+++D KN +++ D+G A+ Y ++ Y + + + PE +V + Sbjct: 123 HSKDIIYRDLKPENILLD-KNGHIKITDFGFAK-YVPDVTYTL-CGTPDYIAPE-VVSTK 178 Query: 247 MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPR 306 Y+ S+D WSFG ++ M+ PF+ SNT +EK +L E+ P Sbjct: 179 PYNKSIDWWSFGILIYEMLAGYTPFYD--SNT-----------MKTYEK-ILNAELRFPP 224 Query: 307 EFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERL-----TAKEAMGHP 361 F N+++ DL+ L+ D +RL ++ HP Sbjct: 225 FF------------------------NEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHP 260 Query: 362 WFAPI 366 WF + Sbjct: 261 WFKEV 265 >5IG1-A nrPDB Length = 344 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 59/240 (24%), Positives = 103/240 (42%), Gaps = 58/240 (24%) Query: 46 VGRGKYSEVFQGVKLDS----KVKIV-IKMLKPVKKKKIKREIKILTDLSNEKVPPTTLP 100 +G+G +S V + V + VK++ +K L+ + KIKREI I + L +E + Sbjct: 25 IGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQHEHIVSMRRA 84 Query: 101 FQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV----- 155 F+ + ++ LVFEYV Sbjct: 85 FRDESHFY-----------------------------------------LVFEYVSGGEL 103 Query: 156 -DNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK--NKKLRL 212 D + R Y + + M ++L AL +CHS I+HRD+KP N+++ K N +++ Sbjct: 104 FDEIVTRKFY---NEKDASACMHQILSALQHCHSKNIIHRDLKPENLLLASKDPNAPVKI 160 Query: 213 IDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFF 272 D+GLA Y + + PE ++ YD ++D+W+ G +L ++ PF+ Sbjct: 161 TDFGLAVIMEQGPTYFGFAGTPGYLSPE-VIRRVPYDTAVDVWACGVILYILLVGYPPFW 219 >2YCR-A nrPDB Length = 323 Score = 68.6 bits (166), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 48/202 (23%), Positives = 89/202 (44%), Gaps = 37/202 (18%) Query: 166 KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK--LRLIDWGLAEFYHV 223 +L + + Y +++L A+ Y H GI+HRD+KP NV++ + + +++ D+G ++ Sbjct: 110 RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGE 169 Query: 224 NMEYNVRVASRFFKGPELLVDYRM--YDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQL 281 + + PE+LV Y+ ++D WS G +L + PF + Sbjct: 170 TSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVS-- 227 Query: 282 VKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLID 341 LK +IT + Y+ +I + W +++ +DL+ Sbjct: 228 ----------------LKDQITSGK--YN---FIPEVWAEV----------SEKALDLVK 256 Query: 342 NLLRYDHQERLTAKEAMGHPWF 363 LL D + R T +EA+ HPW Sbjct: 257 KLLVVDPKARFTTEEALRHPWL 278 >4CFH-A nrPDB Length = 493 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 64/255 (25%), Positives = 105/255 (41%), Gaps = 46/255 (18%) Query: 113 DVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTD 169 DV+ IR I + H +II L+ +I P +V EYV D+ +L + Sbjct: 75 DVVGKIRREIQNLKLFRHPHIIKLYQVISTP--SDIFMVMEYVSGGELFDYICKNGRLDE 132 Query: 170 LEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID-HKNKKLRLIDWGLAEFYHVNMEYN 228 E R ++L +DYCH ++HRD+KP NV++D H N K + D+GL+ Sbjct: 133 KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAK--IADFGLSNMMSDGEFLR 190 Query: 229 VRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVL 288 S + PE++ +D+WS G +L +++ PF + D + + K + Sbjct: 191 TSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF-----DDDHVPTLFKKI 245 Query: 289 GTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDH 348 F QY+ N +I L+ ++L+ D Sbjct: 246 CDGIFY----------------TPQYL-----------------NPSVISLLKHMLQVDP 272 Query: 349 QERLTAKEAMGHPWF 363 +R T K+ H WF Sbjct: 273 MKRATIKDIREHEWF 287 >4REW-A nrPDB Length = 540 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 48/163 (29%), Positives = 77/163 (47%), Gaps = 8/163 (4%) Query: 113 DVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTD 169 DV+ IR I + H +II L+ +I P +V EYV D+ +L + Sbjct: 48 DVVGKIRREIQNLKLFRHPHIIKLYQVISTP--SDIFMVMEYVSGGELFDYICKNGRLDE 105 Query: 170 LEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID-HKNKKLRLIDWGLAEFYHVNMEYN 228 E R ++L +DYCH ++HRD+KP NV++D H N K + D+GL+ Sbjct: 106 KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAK--IADFGLSNMMSDGEFLR 163 Query: 229 VRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 S + PE++ +D+WS G +L +++ PF Sbjct: 164 TSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF 206 >4PDS-A nrPDB Length = 347 Score = 67.8 bits (164), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 66/239 (27%), Positives = 103/239 (43%), Gaps = 54/239 (22%) Query: 150 LVFEYV---DNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK 206 +V E+V D +DF + + + R ++L A+ Y HSMGI HRD+KP N++I+ Sbjct: 106 MVMEFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQD 165 Query: 207 NKKL-RLIDWGLAE------FYHVNMEYNVRVASRFFKGPELLVDYRMY----DYS--LD 253 + L ++ +GLA+ F VA +G + V Y +YS +D Sbjct: 166 DPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVD 225 Query: 254 LWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQ 313 +WS G ++ ++ PF S DQL K Q Sbjct: 226 MWSMGCLVYVILTGHLPF--SGSTQDQLYK-----------------------------Q 254 Query: 314 YIRKPWHRFINDGN-KHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW--FAPIREQ 369 R +H +G K ++E D ID+LL+ D R TA +A+ HPW +P+ Q Sbjct: 255 IGRGSYH----EGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIKMSPLGSQ 309 >3GUB-A nrPDB Length = 295 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 61/243 (25%), Positives = 105/243 (43%), Gaps = 45/243 (18%) Query: 130 HANIIHLFDIIKDPISKTPA-LVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDY 185 H N+I L ++ ++ KT L+ E V DF LT+ E ++ ++L + Y Sbjct: 73 HPNVITLHEVYEN---KTDVILIGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYY 129 Query: 186 CHSMGIMHRDVKPHNVMIDHKN---KKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELL 242 HS+ I H D+KP N+M+ +N ++++ID+GLA E+ + F PE + Sbjct: 130 LHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPE-I 188 Query: 243 VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEI 302 V+Y D+WS G + ++ PF G + + L + V +FE Sbjct: 189 VNYEPLGLEADMWSIGVITYILLSGASPFL-GDTKQETLANVSAV--NYEFED------- 238 Query: 303 TLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 E++ + K D I LL D ++R+T ++++ HPW Sbjct: 239 ----EYFSNTSALAK--------------------DFIRRLLVKDPKKRMTIQDSLQHPW 274 Query: 363 FAP 365 P Sbjct: 275 IKP 277 >2Z7Q-A nrPDB Length = 321 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 61/257 (23%), Positives = 115/257 (44%), Gaps = 37/257 (14%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 +E+ +G+G + +VF K+ + +K +KK +K ++ T + + + Sbjct: 30 FELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNH 89 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVD 159 PF +Y Q E L I ++ + L V Sbjct: 90 PFVVKLHYAFQTEGKLYLILDFL-----------------------RGGDLFTRLSKEVM 126 Query: 160 FRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAE 219 F T+ +++FY+ EL LD+ HS+GI++RD+KP N+++D + ++L D+GL++ Sbjct: 127 F-------TEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEG-HIKLTDFGLSK 178 Query: 220 --FYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSN 277 H Y+ + + PE +V+ + + +S D WS+G ++ M+ P F G Sbjct: 179 EAIDHEKKAYSF-CGTVEYMAPE-VVNRQGHSHSADWWSYGVLMFEMLTGSLP-FQGKDR 235 Query: 278 TDQLVKIVKV-LGTSDF 293 + + I+K LG F Sbjct: 236 KETMTLILKAKLGMPQF 252 >4C0T-A nrPDB Length = 974 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 68/252 (26%), Positives = 112/252 (44%), Gaps = 55/252 (21%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP---VKKKKIKR---EIKILTDL 89 N D++ ++G G YS V + + +K+L +K+KK+K E L L Sbjct: 264 NVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRL 323 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 SN ++ +L Y+T Q +D L F+ D NG L +IK Sbjct: 324 SN-RLGVISL------YFTFQDKDSLYFV----LDYASNGE-----LLTLIK-------- 359 Query: 150 LVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 Y L + R + ++L A+ Y H G++HRD+KP N+++D K + Sbjct: 360 -------------RYNTLNEECTRHFGAQILDAIKYMHDNGVIHRDLKPENILLDDK-MR 405 Query: 210 LRLIDWGLAEFYH----VNMEYNVRVASRFFKG------PELLVDYRMYDYSLDLWSFGT 259 +++ D+G A + EY V V ++ F G PELL + + D+W+FG Sbjct: 406 IQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPELL-ENKYCGKPGDVWAFGC 464 Query: 260 MLASMIFKREPF 271 ++ MI + PF Sbjct: 465 IIYQMIAGKPPF 476 >4AF3-A nrPDB Length = 292 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 79/327 (24%), Positives = 134/327 (40%), Gaps = 79/327 (24%) Query: 39 DYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTT 98 D+EI +G+GK+ V+ + S + +K+L K +I Sbjct: 24 DFEIGRPLGKGKFGNVYLAREKKSHFIVALKVL-------FKSQI--------------- 61 Query: 99 LPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNV 158 +KE V +R I Q H H NI+ L++ D + L+ EY Sbjct: 62 -----------EKEGVEHQLRREIEIQAHLHHPNILRLYNYFYD--RRRIYLILEYAPRG 108 Query: 159 D-FRILYPKLTDLEIRFY--MFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDW 215 + ++ L T E R M EL AL YCH ++HRD+KP N+++ +L++ D+ Sbjct: 109 ELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLG-LKGELKIADF 167 Query: 216 GLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGT 275 G + + ++ + + PE +++ RM++ +DLW G + ++ P F Sbjct: 168 GWS-VHAPSLRRKTMCGTLDYLPPE-MIEGRMHNEKVDLWCIGVLCYELLVGNPP-FESA 224 Query: 276 SNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDE 335 S+ + +IVKV LK+ ++P +G Sbjct: 225 SHNETYRRIVKV---------DLKFPASVP-------------------------TGAQ- 249 Query: 336 IIDLIDNLLRYDHQERLTAKEAMGHPW 362 DLI LLR++ ERL + HPW Sbjct: 250 --DLISKLLRHNPSERLPLAQVSAHPW 274 >3I6U-A nrPDB Length = 419 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 47/202 (23%), Positives = 87/202 (43%), Gaps = 37/202 (18%) Query: 166 KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK--LRLIDWGLAEFYHV 223 +L + + Y +++L A+ Y H GI+HRD+KP NV++ + + +++ D+G ++ Sbjct: 235 RLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGE 294 Query: 224 NMEYNVRVASRFFKGPELLVDYRM--YDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQL 281 + + PE+LV Y+ ++D WS G +L + PF + Sbjct: 295 TSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVS-- 352 Query: 282 VKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLID 341 LK +IT + +I + W +++ +DL+ Sbjct: 353 ----------------LKDQITSGKY-----NFIPEVWAEV----------SEKALDLVK 381 Query: 342 NLLRYDHQERLTAKEAMGHPWF 363 LL D + R T +EA+ HPW Sbjct: 382 KLLVVDPKARFTTEEALRHPWL 403 >2JC6-A nrPDB Length = 334 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 65/240 (27%), Positives = 107/240 (44%), Gaps = 42/240 (17%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDF--RILYPKL-TDLEIRFYMFELLKALDYC 186 H NI+ L DI + P LV + V + RI+ T+ + + ++L A+ Y Sbjct: 79 HENIVALEDIYESP--NHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYL 136 Query: 187 HSMGIMHRDVKPHNVM--IDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVD 244 H MGI+HRD+KP N++ + K+ + D+GL++ + + + PE+L Sbjct: 137 HRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQ 196 Query: 245 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 + Y ++D WS G + ++ PF+ N +L FE+ +LK E Sbjct: 197 -KPYSKAVDCWSIGVIAYILLCGYPPFYD--ENDSKL-----------FEQ-ILKAE--- 238 Query: 305 PREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 Y+ D P+ I+D K D I NL+ D +R T ++A HPW A Sbjct: 239 ----YEFDS----PYWDDISDSAK---------DFIRNLMEKDPNKRYTCEQAARHPWIA 281 >2PMN-X nrPDB Length = 348 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 55/195 (28%), Positives = 93/195 (47%), Gaps = 22/195 (11%) Query: 172 IRFYMFELLKALDYCHS-MGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVR 230 I+ + +L + Y H+ I HRDVKP N+++D KN +++L D+G +E Y V+ + Sbjct: 153 IKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMD-KNGRVKLSDFGESE-YMVDKKIKGS 210 Query: 231 VASRFFKGPELLVDYRMYDYS-LDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLG 289 + F PE + Y+ + +D+WS G L M + PF S LV++ + Sbjct: 211 RGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKIS----LVELFNNIR 266 Query: 290 TSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQ 349 T + E L D + ++ ++ N LS D ID + LR + Sbjct: 267 TKNIEYPL------------DRNHFLYPLTNKKSTCSNNFLSNED--IDFLKLFLRKNPA 312 Query: 350 ERLTAKEAMGHPWFA 364 ER+T+++A+ H W A Sbjct: 313 ERITSEDALKHEWLA 327 >3FXW-A nrPDB Length = 336 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 57/199 (28%), Positives = 86/199 (43%), Gaps = 34/199 (17%) Query: 167 LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK--LRLIDWGLAEFYHVN 224 T+ E M ++ A+ + HS I HRDVKP N++ K K L+L D+G A+ N Sbjct: 125 FTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQN 184 Query: 225 MEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKI 284 + ++ PE+L + YD S D+WS G ++ ++ PF+ SNT Q + Sbjct: 185 A-LQTPCYTPYYVAPEVLGPEK-YDKSCDMWSLGVIMYILLCGFPPFY---SNTGQAISP 239 Query: 285 VKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLL 344 M + IR + F N +S ++ LI LL Sbjct: 240 -------------------------GMKRRIRLGQYGFPNPEWSEVS--EDAKQLIRLLL 272 Query: 345 RYDHQERLTAKEAMGHPWF 363 + D ERLT + M HPW Sbjct: 273 KTDPTERLTITQFMNHPWI 291 >4L42-A nrPDB Length = 346 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/253 (24%), Positives = 113/253 (44%), Gaps = 40/253 (15%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 +E+ +G+G Y +VFQ K+ I +K +KK I R Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRN----------------- 62 Query: 100 PFQKDQYYTNQKEDVLKFIR-PYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNV 158 KD +T + ++L+ ++ P+I D +I+ F L+ EY+ Sbjct: 63 --AKDTAHTKAERNILEEVKHPFIVD--------LIYAFQT-----GGKLYLILEYLSGG 107 Query: 159 DFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDW 215 + + + + FY+ E+ AL + H GI++RD+KP N+M++H+ ++L D+ Sbjct: 108 ELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQG-HVKLTDF 166 Query: 216 GLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHG 274 GL E H + + + PE+L+ ++ ++D WS G ++ M+ P F G Sbjct: 167 GLCKESIHDGTVTHTFCGTIEYMAPEILM-RSGHNRAVDWWSLGALMYDMLTGAPP-FTG 224 Query: 275 TSNTDQLVKIVKV 287 + + KI+K Sbjct: 225 ENRKKTIDKILKC 237 >4RED-A nrPDB Length = 351 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 48/163 (29%), Positives = 77/163 (47%), Gaps = 8/163 (4%) Query: 113 DVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTD 169 DV+ IR I + H +II L+ +I P +V EYV D+ +L + Sbjct: 56 DVVGKIRREIQNLKLFRHPHIIKLYQVISTP--SDIFMVMEYVSGGELFDYICKNGRLDE 113 Query: 170 LEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID-HKNKKLRLIDWGLAEFYHVNMEYN 228 E R ++L +DYCH ++HRD+KP NV++D H N K+ D+GL+ Sbjct: 114 KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIA--DFGLSNMMSDGEFLR 171 Query: 229 VRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 S + PE++ +D+WS G +L +++ PF Sbjct: 172 TSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF 214 >3UTO-A nrPDB Length = 573 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 57/242 (23%), Positives = 103/242 (42%), Gaps = 44/242 (18%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDF--RIL--YPKLTDLEIRFYMFELLKALDY 185 H +++L D +D +++E++ + ++ + K+++ E YM ++ K L + Sbjct: 213 HPTLVNLHDAFED--DNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCH 270 Query: 186 CHSMGIMHRDVKPHNVMIDHK-NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVD 244 H +H D+KP N+M K + +L+LID+GL V + F PE + + Sbjct: 271 MHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPE-VAE 329 Query: 245 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 + Y D+WS G + ++ PF G N D+ ++ VK Sbjct: 330 GKPVGYYTDMWSVGVLSYILLSGLSPF--GGENDDETLRNVKSCD--------------- 372 Query: 305 PREFYDMDQYIRKPWHRFINDGNKHLSG-NDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 ++MD + SG +++ D I LL D R+T +A+ HPW Sbjct: 373 ----WNMD--------------DSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWL 414 Query: 364 AP 365 P Sbjct: 415 TP 416 >4FG9-A nrPDB Length = 320 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 63/241 (26%), Positives = 112/241 (46%), Gaps = 44/241 (18%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDF--RILYPKL-TDLEIRFYMFELLKALDYC 186 H NI+ L DI + L+ + V + RI+ T+ + +F++L A+ Y Sbjct: 75 HPNIVALDDIYES--GGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYL 132 Query: 187 HSMGIMHRDVKPHNVM---IDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLV 243 H +GI+HRD+KP N++ +D ++ K+ + D+GL++ + + + PE+L Sbjct: 133 HDLGIVHRDLKPENLLYYSLD-EDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLA 191 Query: 244 DYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEIT 303 + Y ++D WS G + ++ PF+ N +L FE+ +LK E Sbjct: 192 Q-KPYSKAVDCWSIGVIAYILLCGYPPFY--DENDAKL-----------FEQ-ILKAE-- 234 Query: 304 LPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 Y+ D P+ I+D K D I +L+ D ++R T ++A+ HPW Sbjct: 235 -----YEFDS----PYWDDISDSAK---------DFIRHLMEKDPEKRFTCEQALQHPWI 276 Query: 364 A 364 A Sbjct: 277 A 277 >3BHH-A nrPDB Length = 295 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 78/339 (23%), Positives = 140/339 (41%), Gaps = 87/339 (25%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDS----KVKIV-IKMLKPVKKKKIKREIKILTDLSN 91 T +Y++ +G+G +S V + VKL + KI+ K L +K++RE +I L Sbjct: 3 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLK- 61 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H+NI+ L D I + LV Sbjct: 62 --------------------------------------HSNIVRLHDSISE--EGFHYLV 81 Query: 152 FEYVDNVD-FRILYPK--LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK 208 F+ V + F + + ++ + + ++L+A+ +CH MG++HRD+KP N+++ K K Sbjct: 82 FDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCK 141 Query: 209 --KLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 ++L D+GLA E + + + PE+L Y +D+W+ G +L ++ Sbjct: 142 GAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK-EAYGKPVDIWACGVILYILL 200 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 PF+ + +L + +K G DF P +D Sbjct: 201 VGYPPFW--DEDQHKLYQQIKA-GAYDF-----------PSPEWD--------------- 231 Query: 326 GNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + E +LI+ +L + +R+TA EA+ HPW Sbjct: 232 -----TVTPEAKNLINQMLTINPAKRITAHEALKHPWVC 265 >4RLP-A nrPDB Length = 288 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/253 (24%), Positives = 113/253 (44%), Gaps = 40/253 (15%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 +E+ +G+G Y +VFQ K+ I +K +KK I R Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRN----------------- 49 Query: 100 PFQKDQYYTNQKEDVLKFIR-PYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNV 158 KD +T + ++L+ ++ P+I D +I+ F L+ EY+ Sbjct: 50 --AKDTAHTKAERNILEEVKHPFIVD--------LIYAFQT-----GGKLYLILEYLSGG 94 Query: 159 DFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDW 215 + + + + FY+ E+ AL + H GI++RD+KP N+M++H+ ++L D+ Sbjct: 95 ELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQG-HVKLTDF 153 Query: 216 GLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHG 274 GL E H + + + PE+L+ ++ ++D WS G ++ M+ P F G Sbjct: 154 GLCKESIHDGTVTHTFCGTIEYMAPEILMR-SGHNRAVDWWSLGALMYDMLTGAPP-FTG 211 Query: 275 TSNTDQLVKIVKV 287 + + KI+K Sbjct: 212 ENRKKTIDKILKC 224 >1KOA-A nrPDB Length = 491 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 57/242 (23%), Positives = 101/242 (41%), Gaps = 44/242 (18%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDF----RILYPKLTDLEIRFYMFELLKALDY 185 H +++L D +D +++E++ + + K+++ E YM ++ K L + Sbjct: 107 HPTLVNLHDAFED--DNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCH 164 Query: 186 CHSMGIMHRDVKPHNVMIDHK-NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVD 244 H +H D+KP N+M K + +L+LID+GL V + F PE + + Sbjct: 165 MHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPE-VAE 223 Query: 245 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 + Y D+WS G + ++ PF G N D+ ++ VK Sbjct: 224 GKPVGYYTDMWSVGVLSYILLSGLSPF--GGENDDETLRNVKSCD--------------- 266 Query: 305 PREFYDMDQYIRKPWHRFINDGNKHLSG-NDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 ++MD + SG +++ D I LL D R+T +A+ HPW Sbjct: 267 ----WNMD--------------DSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWL 308 Query: 364 AP 365 P Sbjct: 309 TP 310 >2HW6-A nrPDB Length = 307 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 64/255 (25%), Positives = 103/255 (40%), Gaps = 44/255 (17%) Query: 128 NGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALD 184 G+ NI+ L + +D LVFE + K + E + ++ ALD Sbjct: 68 QGNKNILELIEFFEDDTRFY--LVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALD 125 Query: 185 YCHSMGIMHRDVKPHNVMIDHKNK--KLRLIDWGLAEFYHVNM--------EYNVRVASR 234 + H+ GI HRD+KP N++ + K +++ D+ L +N E S Sbjct: 126 FLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSA 185 Query: 235 FFKGPELLVDYR----MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTD---QLVKIVKV 287 + PE++ + YD DLWS G +L M+ PF G D ++ +V Sbjct: 186 EYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFV-GHCGADCGWDRGEVCRV 244 Query: 288 LGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYD 347 FE I++ + F + H+S E DLI LL D Sbjct: 245 CQNKLFES-------------------IQEGKYEFPDKDWAHIS--SEAKDLISKLLVRD 283 Query: 348 HQERLTAKEAMGHPW 362 ++RL+A + + HPW Sbjct: 284 AKQRLSAAQVLQHPW 298 >2BRG-A nrPDB Length = 297 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 56/242 (23%), Positives = 111/242 (45%), Gaps = 46/242 (19%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK----KKIKREIKILTDLSNE 92 +D+++ +G G Y EV V ++ + +K++ + + IK+EI I L++E Sbjct: 6 VEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHE 65 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF 152 V ++Y +++E ++ Y+F + +G LFD I+ I Sbjct: 66 NVV---------KFYGHRREGNIQ----YLFLEYCSGG----ELFDRIEPDIG------- 101 Query: 153 EYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRL 212 + + + + + +L+ + Y H +GI HRD+KP N+++D ++ L++ Sbjct: 102 --------------MPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERD-NLKI 146 Query: 213 IDWGLAEFYHVNME---YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 D+GLA + N N + + PELL + +D+WS G +L +M+ Sbjct: 147 SDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGEL 206 Query: 270 PF 271 P+ Sbjct: 207 PW 208 >1TKI-A nrPDB Length = 321 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 57/248 (22%), Positives = 114/248 (45%), Gaps = 45/248 (18%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDF--RILYP--KLTDLEIRFYMFELLKALDY 185 H NI+HL + + + ++FE++ +D RI +L + EI Y+ ++ +AL + Sbjct: 60 HRNILHLHESFESM--EELVMIFEFISGLDIFERINTSAFELNEREIVSYVHQVCEALQF 117 Query: 186 CHSMGIMHRDVKPHNVMID-HKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVD 244 HS I H D++P N++ ++ +++I++G A + + + + PE+ Sbjct: 118 LHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYYAPEVH-Q 176 Query: 245 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 + + + D+WS GT++ ++ PF +N + I+ T D E + EI++ Sbjct: 177 HDVVSTATDMWSLGTLVYVLLSGINPFL-AETNQQIIENIMNAEYTFDEEAF---KEISI 232 Query: 305 PREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 E +D +D LL + + R+TA EA+ HPW Sbjct: 233 ------------------------------EAMDFVDRLLVKERKSRMTASEALQHPW-- 260 Query: 365 PIREQIEK 372 ++++IE+ Sbjct: 261 -LKQKIER 267 >5TQX-A nrPDB Length = 655 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 45/155 (29%), Positives = 72/155 (46%), Gaps = 12/155 (7%) Query: 130 HANIIHLFDIIKDP---ISKTPALVFEYVDNVDFRILYPK------LTDLEIRFYMFELL 180 HAN++ D+ ++ I P L EY D R L K L + +I + ++ Sbjct: 65 HANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIG 124 Query: 181 KALDYCHSMGIMHRDVKPHNVMIDHKNKKL--RLIDWGLAEFYHVNMEYNVRVASRFFKG 238 + Y H I+HRD+KP N+++ K+ ++ID G A+ V + + Sbjct: 125 SGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLA 184 Query: 239 PELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFH 273 PEL + + Y ++D WSFGTM+ I PF H Sbjct: 185 PELF-ENKPYTATVDYWSFGTMVFECIAGYRPFLH 218 >3DAK-A nrPDB Length = 290 Score = 65.5 bits (158), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 59/254 (23%), Positives = 111/254 (43%), Gaps = 43/254 (16%) Query: 29 TVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKK----KIKREIK 84 + + WS N DYE++ +G G + V K K+ IK + K + ++ +EI+ Sbjct: 1 SALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQ 60 Query: 85 ILTDLSNEKVPPTTLPFQ-KDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP 143 ++ + + F KD+ + V+K + +G + + DIIK Sbjct: 61 AMSQCHHPNIVSYYTSFVVKDELWL-----VMKLL---------SGGS----VLDIIKHI 102 Query: 144 ISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI 203 ++K E+ V L + I + E+L+ L+Y H G +HRDVK N+++ Sbjct: 103 VAKG-----EHKSGV--------LDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILL 149 Query: 204 DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKG------PELLVDYRMYDYSLDLWSF 257 ++ +++ D+G++ F + + F G PE++ R YD+ D+WSF Sbjct: 150 G-EDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSF 208 Query: 258 GTMLASMIFKREPF 271 G + P+ Sbjct: 209 GITAIELATGAAPY 222 >2JAM-A nrPDB Length = 304 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 61/238 (25%), Positives = 106/238 (44%), Gaps = 43/238 (18%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDF--RILYPKL-TDLEIRFYMFELLKALDYC 186 H NI+ L DI + + LV + V + RIL + T+ + + ++L A+ Y Sbjct: 65 HENIVTLEDIYES--TTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYL 122 Query: 187 HSMGIMHRDVKPHNV--MIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVD 244 H GI+HRD+KP N+ + +N K+ + D+GL++ N + + + PE+L Sbjct: 123 HENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQ-NGIMSTACGTPGYVAPEVLAQ 181 Query: 245 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 + Y ++D WS G + ++ PF+ T + FEK + Sbjct: 182 -KPYSKAVDCWSIGVITYILLCGYPPFYEETE-------------SKLFEK--------I 219 Query: 305 PREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 +Y+ + P+ I++ K D I +LL D ER T ++A+ HPW Sbjct: 220 KEGYYEFES----PFWDDISESAK---------DFICHLLEKDPNERYTCEKALSHPW 264 >4JXF-A nrPDB Length = 266 Score = 65.1 bits (157), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 66/334 (19%), Positives = 136/334 (40%), Gaps = 84/334 (25%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML------KPVKKKKIKREIKILTDLSN 91 +D+++ N +G+G ++ V++ + + +++ IKM+ K ++++ E+KI L + Sbjct: 7 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKH 66 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 + F+ Y + + HNG N Sbjct: 67 PSILELYNYFEDSNYVY------------LVLEMCHNGEMN------------------- 95 Query: 152 FEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 Y+ N R+ ++ E R +M +++ + Y HS GI+HRD+ N+++ +N ++ Sbjct: 96 -RYLKN---RV--KPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLT-RNMNIK 148 Query: 212 LIDWGLAEFYHVNME-YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 + D+GLA + E + + + PE + + D+WS G M +++ R P Sbjct: 149 IADFGLATQLKMPHEKHYTLCGTPNYISPE-IATRSAHGLESDVWSLGCMFYTLLIGRPP 207 Query: 271 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 330 F +TD + + + +D Y+M ++ Sbjct: 208 F-----DTDTVKNTLNKVVLAD----------------YEMPSFL--------------- 231 Query: 331 SGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + E DLI LLR + +RL+ + HP+ + Sbjct: 232 --SIEAKDLIHQLLRRNPADRLSLSSVLDHPFMS 263 >3ORZ-A nrPDB Length = 316 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 54/203 (26%), Positives = 91/203 (44%), Gaps = 49/203 (24%) Query: 173 RFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHV---NMEYNV 229 RFY E++ AL+Y H GI+HRD+KP N++++ ++ +++ D+G A+ N Sbjct: 140 RFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHIQITDFGTAKVLSPESKQARANS 198 Query: 230 RVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLG 289 V + + PELL + S DLW+ G ++ ++ PF G + L+ Sbjct: 199 FVGTAQYVSPELLTEKSACKSS-DLWALGCIIYQLVAGLPPFRAG---NEYLI------- 247 Query: 290 TSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQ 349 F+K ++K E P +F+ P R DL++ LL D Sbjct: 248 ---FQK-IIKLEYDFPEKFF--------PKAR----------------DLVEKLLVLDAT 279 Query: 350 ERLTAKEAMG------HPWFAPI 366 +RL +E G HP+F + Sbjct: 280 KRLGCEEMEGYGPLKAHPFFESV 302 >5UUU-A nrPDB Length = 547 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 65/262 (24%), Positives = 109/262 (41%), Gaps = 41/262 (15%) Query: 15 INKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPV 74 I + + ++N ++ D+ + +GRG + EV+ K D+ +K L Sbjct: 175 IESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLD-- 232 Query: 75 KKKKIKREIKILTDLSNEK-----VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNG 129 KK+IK + L NE+ V PF Y D L FI + NG Sbjct: 233 -KKRIKMKQGETLAL-NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLM-----NG 285 Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSM 189 HL + VF D +RFY E++ L++ H+ Sbjct: 286 GDLHYHL----------SQHGVFSEAD---------------MRFYAAEIILGLEHMHNR 320 Query: 190 GIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYD 249 +++RD+KP N+++D ++ +R+ D GLA + + + V + + PE+L YD Sbjct: 321 FVVYRDLKPANILLD-EHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQKGVAYD 378 Query: 250 YSLDLWSFGTMLASMIFKREPF 271 S D +S G ML ++ PF Sbjct: 379 SSADWFSLGCMLFKLLRGHSPF 400 >3PVW-A nrPDB Length = 695 Score = 64.3 bits (155), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 65/262 (24%), Positives = 109/262 (41%), Gaps = 41/262 (15%) Query: 15 INKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPV 74 I + + ++N ++ D+ + +GRG + EV+ K D+ +K L Sbjct: 166 IESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLD-- 223 Query: 75 KKKKIKREIKILTDLSNEK-----VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNG 129 KK+IK + L NE+ V PF Y D L FI + NG Sbjct: 224 -KKRIKMKQGETLAL-NERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLM-----NG 276 Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSM 189 HL + VF D +RFY E++ L++ H+ Sbjct: 277 GDLHYHL----------SQHGVFSEAD---------------MRFYAAEIILGLEHMHNR 311 Query: 190 GIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYD 249 +++RD+KP N+++D ++ +R+ D GLA + + + V + + PE+L YD Sbjct: 312 FVVYRDLKPANILLD-EHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQKGVAYD 369 Query: 250 YSLDLWSFGTMLASMIFKREPF 271 S D +S G ML ++ PF Sbjct: 370 SSADWFSLGCMLFKLLRGHSPF 391 >5U6Y-A nrPDB Length = 461 Score = 64.3 bits (155), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 61/241 (25%), Positives = 109/241 (45%), Gaps = 43/241 (17%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVD-FRILYPK--LTDLEIRFYMFELLKALDYC 186 H NI+ L D I + L+F+ V + F + + ++ + + ++L+A+ +C Sbjct: 58 HPNIVRLHDSISE--EGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 115 Query: 187 HSMGIMHRDVKPHNVMIDHKNK--KLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLV 243 H MG++HRD+KP N+++ K K ++L D+GLA E + + + PE+L Sbjct: 116 HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR 175 Query: 244 DYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEIT 303 Y +DLW+ G +L ++ PF+ + +L + +K G DF Sbjct: 176 K-DPYGKPVDLWACGVILYILLVGYPPFW--DEDQHRLYQQIKA-GAYDF---------- 221 Query: 304 LPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 P +D + E DLI+ +L + +R+TA EA+ HPW Sbjct: 222 -PSPEWD--------------------TVTPEAKDLINKMLTINPSKRITAAEALKHPWI 260 Query: 364 A 364 + Sbjct: 261 S 261 >3ZUT-A nrPDB Length = 362 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 39/146 (26%), Positives = 71/146 (48%), Gaps = 6/146 (4%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDF--RIL-YPKLTDLEIRFYMFELLKALDYC 186 H NI+ ++I P A+V EY + RI + ++ E RF+ +L+ + YC Sbjct: 74 HPNIVRFKEVILTPTHL--AIVMEYASGGELFERICNAGRFSEDEARFFFQQLISGVSYC 131 Query: 187 HSMGIMHRDVKPHNVMIDHK-NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDY 245 H+M + HRD+K N ++D +L++ +G ++ ++ + V + + PE+L+ Sbjct: 132 HAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKK 191 Query: 246 RMYDYSLDLWSFGTMLASMIFKREPF 271 D+WS G L M+ PF Sbjct: 192 EYDGKVADVWSCGVTLYVMLVGAYPF 217 >6F3F-A nrPDB Length = 455 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/257 (22%), Positives = 108/257 (42%), Gaps = 46/257 (17%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--VKKKKIKREIKILTDLS 90 W + +E K+G+G + EV+ G + ++ IK LKP + + +E +++ L Sbjct: 182 WEIPRESLRLEVKLGQGCFGEVWMGT-WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR 240 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 +EK+ Q Y E+ + + Y+ N L D +K K L Sbjct: 241 HEKLV---------QLYAVVSEEPIYIVTEYM---------NKGSLLDFLKGETGKYLRL 282 Query: 151 VFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 P+L D+ ++ + Y M +HRD++ N+++ +N Sbjct: 283 --------------PQLVDMSA-----QIASGMAYVERMNYVHRDLRAANILVG-ENLVC 322 Query: 211 RLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 ++ D+GLA N EY R ++F + PE + Y + D+WSFG +L + K Sbjct: 323 KVADFGLARLIEDN-EYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTK 380 Query: 268 REPFFHGTSNTDQLVKI 284 + G N + L ++ Sbjct: 381 GRVPYPGMVNREVLDQV 397 >5F9E-A nrPDB Length = 353 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 57/240 (23%), Positives = 106/240 (44%), Gaps = 39/240 (16%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 +D+E+ +G+G + +VF + IK LK K + + + + ++V Sbjct: 19 EDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALK---KDVVLMDDDVECTMVEKRVLSL 75 Query: 98 TL--PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 PF + T Q ++ L F+ Y+ H H FD+ + Sbjct: 76 AWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR-------------- 121 Query: 156 DNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDW 215 FY E++ L + HS GI++RD+K N+++D K+ +++ D+ Sbjct: 122 ----------------ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLD-KDGHIKIADF 164 Query: 216 GLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHG 274 G+ E + + N + + PE+L+ + Y++S+D WSFG +L M+ + P FHG Sbjct: 165 GMCKENMLGDAKTNEFCGTPDYIAPEILLGQK-YNHSVDWWSFGVLLYEMLIGQSP-FHG 222 >2VZ6-A nrPDB Length = 313 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 60/241 (24%), Positives = 107/241 (44%), Gaps = 43/241 (17%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDF---RILYPKLTDLEIRFYMFELLKALDYC 186 H NI+ L D I + L+F+ V + + ++ + + ++L+A+ +C Sbjct: 80 HPNIVRLHDSISE--EGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHC 137 Query: 187 HSMGIMHRDVKPHNVMIDHKNK--KLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLV 243 H MG++HRD+KP N+++ K K ++L D+GLA E + + + PE+L Sbjct: 138 HQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLR 197 Query: 244 DYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEIT 303 Y +DLW+ G +L ++ PF+ + +L + +K G DF Sbjct: 198 K-DPYGKPVDLWACGVILYILLVGYPPFW--DEDQHRLYQQIKA-GAYDF---------- 243 Query: 304 LPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 P +D + E DLI+ +L + +R+TA EA+ HPW Sbjct: 244 -PSPEWD--------------------TVTPEAKDLINKMLTINPSKRITAAEALKHPWI 282 Query: 364 A 364 + Sbjct: 283 S 283 >5FG8-A nrPDB Length = 285 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 72/342 (21%), Positives = 149/342 (43%), Gaps = 82/342 (23%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK-----KKIKREIKILTDLSN 91 + +Y+I+ ++G+G +S V + V+ + + K++ K +K++RE +I L + Sbjct: 13 SDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHH 72 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 + Q++ Y+ Y+ +FD++ T + Sbjct: 73 PNIVRLHDSIQEENYH-------------YL-------------VFDLV------TGGEL 100 Query: 152 FEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK--K 209 FE + +F ++ + + ++L+++++CH G++HRD+KP N+++ K K Sbjct: 101 FEDIVAREF------YSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAA 154 Query: 210 LRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 268 ++L D+GLA E + + + + PE+L Y S+D+W+ G +L ++ Sbjct: 155 VKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVL-KKEPYGKSVDIWACGVILYILLVGY 213 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 PF+ + +L +K G D+ P +D Sbjct: 214 PPFW--DEDQHRLYSQIKA-GAYDY-----------PSPEWD------------------ 241 Query: 329 HLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQI 370 + E +LI+ +L + +R+TA EA+ HPW RE++ Sbjct: 242 --TVTPEAKNLINQMLTVNPNKRITAAEALKHPWICQ-RERV 280 >1ZXE-A nrPDB Length = 303 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 47/177 (26%), Positives = 84/177 (47%), Gaps = 21/177 (11%) Query: 178 ELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME----------- 226 ++L+AL Y HS GI+HR++KP N+ ID +++ +++ D+GLA+ H +++ Sbjct: 124 QILEALSYIHSQGIIHRNLKPMNIFID-ESRNVKIGDFGLAKNVHRSLDILKLDSQNLPG 182 Query: 227 ----YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLV 282 + + + E+L Y+ +D++S G + MI+ PF G + L Sbjct: 183 SSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY---PFSTGMERVNILK 239 Query: 283 KI--VKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEII 337 K+ V + DF+ +K E + R D D R +N G + DE+I Sbjct: 240 KLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWLPVKHQDEVI 296 >4IAN-A nrPDB Length = 358 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 34/110 (30%), Positives = 58/110 (52%), Gaps = 3/110 (2%) Query: 172 IRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRV 231 +R Y +L AL I+H D+KP N++++ L+L D+G A N + + Sbjct: 137 VRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADN-DITPYL 195 Query: 232 ASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQL 281 SRF++ PE+++ + YDY +D+WS G L + + + F G +N L Sbjct: 196 VSRFYRAPEIIIG-KSYDYGIDMWSVGCTLYEL-YTGKILFPGKTNNHML 243 >1PHK-A nrPDB Length = 298 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 56/244 (22%), Positives = 105/244 (43%), Gaps = 45/244 (18%) Query: 128 NGHANIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALD 184 +GH NII L D + + LVF+ + D+ L++ E R M LL+ + Sbjct: 81 SGHPNIIQLKDTYE--TNTFFFLVFDLMKKGELFDYLTEKVTLSEKETRKIMRALLEVIC 138 Query: 185 YCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLV- 243 H + I+HRD+KP N+++D + ++L D+G + + + + PE++ Sbjct: 139 ALHKLNIVHRDLKPENILLD-DDMNIKLTDFGFSCQLDPGEKLREVCGTPSYLAPEIIEC 197 Query: 244 ----DYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLK 299 ++ Y +D+WS G ++ +++ PF+H K +L Sbjct: 198 SMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWH--------------------RKQMLM 237 Query: 300 YEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMG 359 + + + Q+ W + +D + DL+ L Q+R TA+EA+ Sbjct: 238 LRMIMSGNY----QFGSPEWDDY----------SDTVKDLVSRFLVVQPQKRYTAEEALA 283 Query: 360 HPWF 363 HP+F Sbjct: 284 HPFF 287 >5JZN-A nrPDB Length = 280 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 59/239 (24%), Positives = 108/239 (45%), Gaps = 43/239 (17%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYV---DNVDFRILYPKLTDLEIRFYMFELLKALDYC 186 H NI+ L + + P LV E V D D K T+ + ++ L A+ Y Sbjct: 76 HPNIVLLIEEMDVPTELY--LVMELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYL 133 Query: 187 HSMGIMHRDVKPHNVMI-DHK--NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLV 243 HS+ I+HRD+KP N+++ +H+ +K L+L D+GLA V+ + + PE++ Sbjct: 134 HSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATI--VDGPLYTVCGTPTYVAPEIIA 191 Query: 244 DYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEIT 303 + Y +D+W+ G ++ ++ P F G+ + +++ ++G DF Sbjct: 192 ETG-YGLKVDIWAAG-VITYILLCGFPPFRGSGDDQEVLFDQILMGQVDF---------- 239 Query: 304 LPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 P ++D ++D K +LI +L D +R +A + + HPW Sbjct: 240 -PSPYWDN-----------VSDSAK---------ELITMMLLVDVDQRFSAVQVLEHPW 277 >6DBM-A nrPDB Length = 318 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 49/186 (26%), Positives = 91/186 (48%), Gaps = 20/186 (10%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMF--ELLKALDYCH 187 H +II +D + + LV EYV R P+ + + +F ++ + + Y H Sbjct: 92 HEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLH 151 Query: 188 SMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-------EFYHVNMEYNVRVASRFFKGPE 240 S +HRD+ NV++D+ ++ +++ D+GLA E+Y V + + V F+ PE Sbjct: 152 SQHYIHRDLAARNVLLDN-DRLVKIGDFGLAKAVPEGHEYYRVREDGDSPV---FWYAPE 207 Query: 241 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 300 L +Y+ Y Y+ D+WSFG L ++ H S+ K ++++G + + +L+ Sbjct: 208 CLKEYKFY-YASDVWSFGVTLYELL------THCDSSQSPPTKFLELIGIAQGQMTVLRL 260 Query: 301 EITLPR 306 L R Sbjct: 261 TELLER 266 >6BDL-A nrPDB Length = 347 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 31/103 (30%), Positives = 58/103 (56%), Gaps = 2/103 (1%) Query: 169 DLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYN 228 D RFY +++A Y HS GI++RD+KP N+++DH+ +L+D+G A+ + Sbjct: 134 DSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYA-KLVDFGFAKKIGFGKKTW 192 Query: 229 VRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 + + PE++++ + +D S D WS G ++ ++ PF Sbjct: 193 TFCGTPEYVAPEIILN-KGHDISADYWSLGILMYELLTGSPPF 234 >3UDB-A nrPDB Length = 317 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 42/169 (24%), Positives = 80/169 (47%), Gaps = 6/169 (3%) Query: 107 YTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDF--RIL- 163 Y + E + + ++ I + H NI+ ++I P A+V EY + RI Sbjct: 51 YIERGEKIDENVKREIINHRSLRHPNIVRFKEVILTPTHL--AIVMEYASGGELFERICN 108 Query: 164 YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK-NKKLRLIDWGLAEFYH 222 + ++ E RF+ +L+ + Y H+M + HRD+K N ++D +L++ D+G ++ Sbjct: 109 AGRFSEDEARFFFQQLISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASV 168 Query: 223 VNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 ++ + V + + PE+L+ D+WS G L M+ PF Sbjct: 169 LHSQPKSAVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPF 217 >6CCF-A nrPDB Length = 290 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 35/149 (23%), Positives = 76/149 (51%), Gaps = 8/149 (5%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYC 186 H N++ L +++ DP LVF+ + ++ P ++ + R Y+ +++ L+Y Sbjct: 87 HVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKP-FSEEQARLYLRDVILGLEYL 145 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDY 245 H I+HRD+KP N+++ + +++ D+G++ +F + + + + F PE + D Sbjct: 146 HCQKIVHRDIKPSNLLLG-DDGHVKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDS 204 Query: 246 --RMYDYSLDLWSFGTMLASMIFKREPFF 272 +LD+W+ G L ++ + PF Sbjct: 205 GQSFSGKALDVWATGVTLYCFVYGKCPFI 233 >2DQ7-X nrPDB Length = 283 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 57/257 (22%), Positives = 108/257 (42%), Gaps = 46/257 (17%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--VKKKKIKREIKILTDLS 90 W + ++ ++G G++ EV+ G + K+ IK LKP + + E +I+ L Sbjct: 4 WEIPRESLQLIKRLGNGQFGEVWMGT-WNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLK 62 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 ++K+ Q Y E+ + + Y+ N L D +KD + L Sbjct: 63 HDKL---------VQLYAVVSEEPIYIVTEYM---------NKGSLLDFLKDGEGRALKL 104 Query: 151 VFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 P L D+ ++ + Y M +HRD++ N+++ + Sbjct: 105 --------------PNLVDMAA-----QVAAGMAYIERMNYIHRDLRSANILVGN-GLIC 144 Query: 211 RLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 ++ D+GLA N EY R ++F + PE + Y + D+WSFG +L ++ K Sbjct: 145 KIADFGLARLIEDN-EYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELVTK 202 Query: 268 REPFFHGTSNTDQLVKI 284 + G +N + L ++ Sbjct: 203 GRVPYPGMNNREVLEQV 219 >3SOA-A nrPDB Length = 444 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 76/347 (21%), Positives = 141/347 (40%), Gaps = 87/347 (25%) Query: 29 TVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVK-----IVIKMLKPVKKKKIKREI 83 I + T++Y++ ++G+G +S V + VK+ + + I K L +K++RE Sbjct: 2 ATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREA 61 Query: 84 KILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP 143 +I L H NI+ L D I + Sbjct: 62 RICRLLK---------------------------------------HPNIVRLHDSISE- 81 Query: 144 ISKTPALVFEYVDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHN 200 L+F+ V + + ++ + + ++L+A+ +CH MG++HR++KP N Sbjct: 82 -EGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPEN 140 Query: 201 VMIDHKNK--KLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSF 257 +++ K K ++L D+GLA E + + + PE+L Y +DLW+ Sbjct: 141 LLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK-DPYGKPVDLWAC 199 Query: 258 GTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRK 317 G +L ++ PF+ + +L + +K G DF P +D Sbjct: 200 GVILYILLVGYPPFW--DEDQHRLYQQIKA-GAYDF-----------PSPEWD------- 238 Query: 318 PWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + E DLI+ +L + +R+TA EA+ HPW + Sbjct: 239 -------------TVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 272 >2VN9-A nrPDB Length = 301 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 59/241 (24%), Positives = 107/241 (44%), Gaps = 43/241 (17%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDF---RILYPKLTDLEIRFYMFELLKALDYC 186 H NI+ L D I + LVF+ V + + ++ + + ++L+++++C Sbjct: 62 HPNIVRLHDSISE--EGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHC 119 Query: 187 HSMGIMHRDVKPHNVMIDHKNK--KLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLV 243 H GI+HRD+KP N+++ K+K ++L D+GLA E + + + PE+L Sbjct: 120 HLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLR 179 Query: 244 DYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEIT 303 Y +D+W+ G +L ++ PF+ + +L + +K G DF Sbjct: 180 K-DPYGKPVDMWACGVILYILLVGYPPFW--DEDQHRLYQQIKA-GAYDF---------- 225 Query: 304 LPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 P +D + E DLI+ +L + +R+TA EA+ HPW Sbjct: 226 -PSPEWD--------------------TVTPEAKDLINKMLTINPAKRITASEALKHPWI 264 Query: 364 A 364 Sbjct: 265 C 265 >4OLI-A nrPDB Length = 645 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 49/186 (26%), Positives = 91/186 (48%), Gaps = 20/186 (10%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMF--ELLKALDYCH 187 H +II +D K+ LV EYV R P+ + + +F ++ + + Y H Sbjct: 414 HEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLH 473 Query: 188 SMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-------EFYHVNMEYNVRVASRFFKGPE 240 S +HR++ NV++D+ ++ +++ D+GLA E+Y V + + V F+ PE Sbjct: 474 SQHYIHRNLAARNVLLDN-DRLVKIGDFGLAKAVPEGHEYYRVREDGDSPV---FWYAPE 529 Query: 241 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 300 L +Y+ Y Y+ D+WSFG L ++ H S+ K ++++G + + +L+ Sbjct: 530 CLKEYKFY-YASDVWSFGVTLYELL------THCDSSQSPPTKFLELIGIAQGQMTVLRL 582 Query: 301 EITLPR 306 L R Sbjct: 583 TELLER 588 >6ED6-A nrPDB Length = 415 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 66/245 (26%), Positives = 108/245 (44%), Gaps = 47/245 (19%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKI-VIKMLKPVKKKKIKREIKILTDLSNEKVP 95 +DY++ +GRG + EV Q V+ + K+ +K+L K + IKR Sbjct: 87 AEDYDVVKVIGRGAFGEV-QLVRHKASQKVYAMKLLS--KFEMIKR-------------- 129 Query: 96 PTTLPFQKDQYYTNQKEDVLKFI-RPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 D + ++ D++ F P++ + LF +D + +V EY Sbjct: 130 -------SDSAFFWEERDIMAFANSPWV-----------VQLFYAFQD--DRYLYMVMEY 169 Query: 155 VDNVDFRILYPKLTDLE--IRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRL 212 + D L E +FY E++ ALD HSMG++HRDVKP N+++D K+ L+L Sbjct: 170 MPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLD-KHGHLKL 228 Query: 213 IDWGLA-EFYHVNMEY-NVRVASRFFKGPELLVDY---RMYDYSLDLWSFGTMLASMIFK 267 D+G + M + + V + + PE+L Y D WS G L M+ Sbjct: 229 ADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVG 288 Query: 268 REPFF 272 PF+ Sbjct: 289 DTPFY 293 >5SYS-A nrPDB Length = 286 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 56/257 (21%), Positives = 107/257 (41%), Gaps = 46/257 (17%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--VKKKKIKREIKILTDLS 90 W + +E K+G+G + E + G + ++ IK LKP + + +E +++ L Sbjct: 13 WEIPRESLRLEVKLGQGCFGECWMGT-WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR 71 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 +EK+ Q Y E+ + + Y+ L D +K + K Sbjct: 72 HEKL---------VQLYAVVSEEPIYIVTEYMSKG---------SLLDFLKGEMGKY--- 110 Query: 151 VFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 + P+L D+ ++ + Y M +HRD++ N+++ +N Sbjct: 111 -----------LRLPQLVDMAA-----QIASGMAYVERMNYVHRDLRAANILVG-ENLVC 153 Query: 211 RLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 ++ D+GLA N EY R ++F + PE + Y + D+WSFG +L + K Sbjct: 154 KVADFGLARLIEDN-EYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTK 211 Query: 268 REPFFHGTSNTDQLVKI 284 + G N + L ++ Sbjct: 212 GRVPYPGMVNREVLDQV 228 >4QMW-A nrPDB Length = 310 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 56/231 (24%), Positives = 107/231 (46%), Gaps = 47/231 (20%) Query: 45 KVGRGKYSEVFQGVKLDSKVKIVIKML----KPVKKKKIKREIKILTDLSNEKVPPTTLP 100 K+G+G + EVF+G+ ++ + IK++ + + I++EI +L+ + P Sbjct: 36 KIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS--------P 87 Query: 101 FQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDF 160 + Y + K+ L I Y+ G + + L + P+ +T Sbjct: 88 YVTKYYGSYLKDTKLWIIMEYL------GGGSALDLLE--PGPLDET------------- 126 Query: 161 RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-E 219 +I + E+LK LDY HS +HRD+K NV++ ++ +++L D+G+A + Sbjct: 127 ----------QIATILREILKGLDYLHSEKKIHRDIKAANVLLS-EHGEVKLADFGVAGQ 175 Query: 220 FYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 ++ N V + F+ PE ++ YD D+WS G + A + + EP Sbjct: 176 LTDTQIKRNTFVGTPFWMAPE-VIKQSAYDSKADIWSLG-ITAIELARGEP 224 >2H8H-A nrPDB Length = 535 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 57/257 (22%), Positives = 107/257 (41%), Gaps = 46/257 (17%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--VKKKKIKREIKILTDLS 90 W + +E K+G+G + EV+ G + ++ IK LKP + + +E +++ L Sbjct: 262 WEIPRESLRLEVKLGQGCFGEVWMGT-WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR 320 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 +EK+ Q Y E+ + + Y+ L D +K K Sbjct: 321 HEKL---------VQLYAVVSEEPIYIVTEYMSKG---------SLLDFLKGETGK---- 358 Query: 151 VFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 + P+L D+ ++ + Y M +HRD++ N+++ +N Sbjct: 359 ----------YLRLPQLVDMAA-----QIASGMAYVERMNYVHRDLRAANILVG-ENLVC 402 Query: 211 RLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 ++ D+GLA N EY R ++F + PE + Y + D+WSFG +L + K Sbjct: 403 KVADFGLARLIEDN-EYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTK 460 Query: 268 REPFFHGTSNTDQLVKI 284 + G N + L ++ Sbjct: 461 GRVPYPGMVNREVLDQV 477 >2BDW-A nrPDB Length = 362 Score = 61.6 bits (148), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 59/243 (24%), Positives = 110/243 (45%), Gaps = 48/243 (19%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYV------DNVDFRILYPKLTDLEIRFYMFELLKAL 183 H NI+ L D I++ LVF+ V +++ R Y ++ + + ++L+++ Sbjct: 87 HPNIVRLHDSIQE--ESFHYLVFDLVTGGELFEDIVAREFY---SEADASHCIQQILESI 141 Query: 184 DYCHSMGIMHRDVKPHNVMIDHKNK--KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPEL 241 YCHS GI+HR++KP N+++ K K ++L D+GLA + + ++ + + PE+ Sbjct: 142 AYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEV 201 Query: 242 LVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYE 301 L Y +D+W+ G +L ++ PF+ D +++ L + Sbjct: 202 L-KKDPYSKPVDIWACGVILYILLVGYPPFW-------------------DEDQHRLYAQ 241 Query: 302 ITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHP 361 I YD Y W E LID++L + ++R+TA +A+ P Sbjct: 242 IKAGA--YD---YPSPEWDTV----------TPEAKSLIDSMLTVNPKKRITADQALKVP 286 Query: 362 WFA 364 W Sbjct: 287 WIC 289 >4EQM-A nrPDB Length = 294 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 47/173 (27%), Positives = 78/173 (45%), Gaps = 11/173 (6%) Query: 110 QKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILY----P 165 +KE+ LK + + H NI+ + D+ D LV EY++ P Sbjct: 50 EKEETLKRFEREVHNSSQLSHQNIVSMIDV--DEEDDCYYLVMEYIEGPTLSEYIESHGP 107 Query: 166 KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVN- 224 D I F ++L + + H M I+HRD+KP N++ID NK L++ D+G+A+ Sbjct: 108 LSVDTAINF-TNQILDGIKHAHDMRIVHRDIKPQNILID-SNKTLKIFDFGIAKALSETS 165 Query: 225 -MEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTS 276 + N + + + PE D D++S G +L M+ PF T+ Sbjct: 166 LTQTNHVLGTVQYFSPE-QAKGEATDECTDIYSIGIVLYEMLVGEPPFNGETA 217 >3LLT-A nrPDB Length = 360 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 36/121 (29%), Positives = 63/121 (52%), Gaps = 33/121 (27%) Query: 171 EIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID------------------------HK 206 +I+ Y E+LKAL+Y M + H D+KP N+++D K Sbjct: 138 DIKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTK 197 Query: 207 NKKLRLIDWGLAEF---YHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLAS 263 + ++LID+G A F YH ++ + +R ++ PE++++ +D S D+WSFG +LA Sbjct: 198 STGIKLIDFGCATFKSDYHGSI-----INTRQYRAPEVILNLG-WDVSSDMWSFGCVLAE 251 Query: 264 M 264 + Sbjct: 252 L 252 >5O2C-A nrPDB Length = 380 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 67/327 (20%), Positives = 139/327 (42%), Gaps = 79/327 (24%) Query: 45 KVGRGKYSEVFQGVKLDSKVKIVI-----KMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 ++GRG + V++G+ ++ V++ + L ++++ K E ++L L + P + Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQH----PNIV 87 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVD 159 F D + E +LK G I+ + +++ KT Y+ Sbjct: 88 RFY-DSW-----ESILK------------GKKCIVLVTELMTSGTLKT------YLKR-- 121 Query: 160 FRILYPKLTDLEIRFYMFELLKALDYCHSMG--IMHRDVKPHNVMIDHKNKKLRLIDWGL 217 F+++ PK+ +R + ++LK L + H+ I+HRD+K N+ I +++ D GL Sbjct: 122 FKVMKPKV----LRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGL 177 Query: 218 AEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSN 277 A + +V + + F PE+ ++ YD S+D+++FG + M P+ + Sbjct: 178 ATLMRTSFAKSV-IGTPEFMAPEMYEEH--YDESVDVYAFGMCMLEMATSEYPYSECQNA 234 Query: 278 TDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEII 337 K+ + + F K +T P E+ Sbjct: 235 AQIYRKVTSGIKPASFNK------VTDP-----------------------------EVK 259 Query: 338 DLIDNLLRYDHQERLTAKEAMGHPWFA 364 ++I+ +R + ERL+ ++ + H +FA Sbjct: 260 EIIEGCIRQNKSERLSIRDLLNHAFFA 286 >3QA8-A nrPDB Length = 676 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 57/245 (23%), Positives = 102/245 (41%), Gaps = 48/245 (19%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKM----LKPVKKKKIKREIKILTDLSNEKVP 95 +E++ ++G G + V + + D+ ++ IK L P +++ EI+I+ L++ V Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKLNHPNV- 74 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 + D L+ + P + P L EY Sbjct: 75 ----------VSAREVPDGLQKLAP------------------------NDLPLLAMEYC 100 Query: 156 DNVDFRILYPK------LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 + D R + L + IR + ++ AL Y H I+HRD+KP N+++ ++ Sbjct: 101 EGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALRYLHENRIIHRDLKPENIVLQPGPQR 160 Query: 210 L--RLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 L ++ID G A+ V + + PELL + + Y ++D WSFGT+ I Sbjct: 161 LIHKIIDLGYAKELDQGELCTEFVGTLQYLAPELL-EQKKYTVTVDYWSFGTLAFECITG 219 Query: 268 REPFF 272 PF Sbjct: 220 FRPFL 224 >5O2B-A nrPDB Length = 285 Score = 61.2 bits (147), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 68/347 (19%), Positives = 146/347 (42%), Gaps = 79/347 (22%) Query: 25 DYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVI-----KMLKPVKKKKI 79 + E + S + + + + ++GRG + V++G+ ++ V++ + L ++++ Sbjct: 3 EAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRF 62 Query: 80 KREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDI 139 K E ++L L + P + F + E +LK G I+ + ++ Sbjct: 63 KEEAEMLKGLQH----PNIVRFY------DSWESILK------------GKKCIVLVTEL 100 Query: 140 IKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMG--IMHRDVK 197 + KT Y+ F+++ PK+ +R + ++LK L + H+ I+HRD+K Sbjct: 101 MTSGTLKT------YLKR--FKVMKPKV----LRSWCRQILKGLQFLHTRTPPIIHRDLK 148 Query: 198 PHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSF 257 N+ I +++ D GLA + +V + + F PE+ ++ YD S+D+++F Sbjct: 149 CDNIFITGPTGSVKIGDLGLATLMRTSFAKSV-IGTPEFMAPEMYEEH--YDESVDVYAF 205 Query: 258 GTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRK 317 G + M P+ + K+ + + F K +T P Sbjct: 206 GMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNK------VTDP------------ 247 Query: 318 PWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 E+ ++I+ +R + ERL+ ++ + H +FA Sbjct: 248 -----------------EVKEIIEGCIRQNKSERLSIRDLLNHAFFA 277 >5X8I-B nrPDB Length = 346 Score = 61.2 bits (147), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 73/366 (19%), Positives = 160/366 (43%), Gaps = 77/366 (21%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVK-IVIKMLKPVKK--KKIKREIKILTDLSNEKVPP 96 YEI + +G G + +V + + + + + +K++K V + + + EI++L L+ Sbjct: 15 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 74 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 T Q +++ H+GH I+ F+++ ++++ Sbjct: 75 TFRCVQMLEWFE------------------HHGHICIV--FELLG-------LSTYDFIK 107 Query: 157 NVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK---------- 206 F P D IR +++ K++++ HS + H D+KP N++ Sbjct: 108 ENGF---LPFRLD-HIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKI 163 Query: 207 --------NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFG 258 N ++++D+G A + + ++ V++R ++ PE+++ + D+WS G Sbjct: 164 KRDERTLINPDIKVVDFGSATY--DDEHHSTLVSTRHYRAPEVILALG-WSQPCDVWSIG 220 Query: 259 TMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKP 318 +L F + + L + ++LG K++++ T R+++ D R Sbjct: 221 CILIEYYLGF-TVFPTHDSKEHLAMMERILGP--LPKHMIQK--TRKRKYFHHD---RLD 272 Query: 319 W------HRFINDGNKHLSG--------NDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 W R+++ K L ++ + DLI +L YD +R+T +EA+ HP+F Sbjct: 273 WDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFD 332 Query: 365 PIREQI 370 +++ I Sbjct: 333 LLKKSI 338 >5DYK-A nrPDB Length = 853 Score = 61.2 bits (147), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 35/115 (30%), Positives = 63/115 (54%), Gaps = 6/115 (5%) Query: 167 LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME 226 L+ + +FY+ ++ A++Y H I++RD+KP N+++D K ++LID+G A+ V Sbjct: 636 LSKSQAQFYLGSIILAIEYLHERNIVYRDLKPENILLD-KQGYVKLIDFGCAK--KVQGR 692 Query: 227 YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQL 281 V + + PE+++ + Y ++D+W+ G L I PF G DQL Sbjct: 693 AYTLVGTPHYMAPEVILG-KGYGCTVDIWALGICLYEFICGPLPF--GNDEEDQL 744 >2XNP-A nrPDB Length = 279 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 46/155 (29%), Positives = 74/155 (47%), Gaps = 15/155 (9%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTD----LEIRFY---MFELLKA 182 H NI+ +D I D + T +V EY + D + K T L+ F M +L A Sbjct: 64 HPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLA 123 Query: 183 LDYCHSMG-----IMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEY-NVRVASRFF 236 L CH ++HRD+KP NV +D K + ++L D+GLA + + + V + ++ Sbjct: 124 LKECHRRSDGGHTVLHRDLKPANVFLDGK-QNVKLGDFGLARILNHDTSFAKTFVGTPYY 182 Query: 237 KGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 PE + + Y+ D+WS G +L + PF Sbjct: 183 MSPEQM-NRMSYNEKSDIWSLGCLLYELCALMPPF 216 >3A8W-A nrPDB Length = 345 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 53/195 (27%), Positives = 90/195 (46%), Gaps = 20/195 (10%) Query: 121 YIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYP---KLTDLEIRFYMF 177 ++F+Q N H ++ L + V EYV+ D KL + RFY Sbjct: 61 HVFEQASN-HPFLVGLHSCFQ--TESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSA 117 Query: 178 ELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-EFYHVNMEYNVRVASRFF 236 E+ AL+Y H GI++RD+K NV++D + ++L D+G+ E + + + Sbjct: 118 EISLALNYLHERGIIYRDLKLDNVLLDSEG-HIKLTDYGMCKEGLRPGDTTSTFCGTPNY 176 Query: 237 KGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF--FHGTSNTDQLVKIVKVLGTSDFE 294 PE+L Y +S+D W+ G ++ M+ R PF + N DQ T D+ Sbjct: 177 IAPEILRG-EDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQ--------NTEDYL 227 Query: 295 -KYLLKYEITLPREF 308 + +L+ +I +PR Sbjct: 228 FQVILEKQIRIPRSL 242 >2JD5-A nrPDB Length = 373 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 80/354 (22%), Positives = 160/354 (45%), Gaps = 67/354 (18%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--VKKKKIKREIKIL---TDLSNEKV 94 Y + K+G G +S V+ + + + +K+++ V + + EIK+L D N K Sbjct: 21 YILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTK- 79 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 +D N +LK + + P+ H ++ +F+++ + + AL+ +Y Sbjct: 80 --------EDSMGANH---ILKLLDHFNHKGPNGVH--VVMVFEVLGENLL---ALIKKY 123 Query: 155 VDNVDFRILYPKLTDLEIRFYMFELLKALDYCHS-MGIMHRDVKPHNVMIDHKNK----- 208 ++ ++Y ++ +LL LDY H GI+H D+KP NV+++ + Sbjct: 124 -EHRGIPLIY-------VKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLI 175 Query: 209 KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI--- 265 ++++ D G A +Y + Y + +R ++ PE+L+ + D+WS ++ +I Sbjct: 176 QIKIADLGNACWY--DEHYTNSIQTREYRSPEVLLG-APWGCGADIWSTACLIFELITGD 232 Query: 266 --FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIR-----KP 318 F+ + T + D + +I+++LG + YLL+ R F++ +R K Sbjct: 233 FLFEPDEGHSYTKDDDHIAQIIELLG--ELPSYLLR-NGKYTRTFFNSRGLLRNISKLKF 289 Query: 319 W---------HRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 W ++F D K EI D + +L+ D ++R A + HPW Sbjct: 290 WPLEDVLTEKYKFSKDEAK------EISDFLSPMLQLDPRKRADAGGLVNHPWL 337 >3KK8-A nrPDB Length = 284 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 59/243 (24%), Positives = 110/243 (45%), Gaps = 48/243 (19%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYV------DNVDFRILYPKLTDLEIRFYMFELLKAL 183 H NI+ L D I++ LVF+ V +++ R Y ++ + + ++L+++ Sbjct: 64 HPNIVRLHDSIQE--ESFHYLVFDLVTGGELFEDIVAREFY---SEADASHCIQQILESI 118 Query: 184 DYCHSMGIMHRDVKPHNVMIDHKNK--KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPEL 241 YCHS GI+HR++KP N+++ K K ++L D+GLA + + ++ + + PE+ Sbjct: 119 AYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEV 178 Query: 242 LVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYE 301 L Y +D+W+ G +L ++ PF+ D +++ L + Sbjct: 179 L-KKDPYSKPVDIWACGVILYILLVGYPPFW-------------------DEDQHRLYAQ 218 Query: 302 ITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHP 361 I YD Y W E LID++L + ++R+TA +A+ P Sbjct: 219 IKAGA--YD---YPSPEWDTV----------TPEAKSLIDSMLTVNPKKRITADQALKVP 263 Query: 362 WFA 364 W Sbjct: 264 WIC 266 >5FET-A nrPDB Length = 847 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 46/159 (28%), Positives = 76/159 (47%), Gaps = 11/159 (6%) Query: 126 PHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDL---EIRFYMFELLKA 182 N H II L KD S + E V + KL L + +FY+ ++ A Sbjct: 588 AENDHPFIIRLVRTFKD--SNCFYFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILA 645 Query: 183 LDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELL 242 ++Y H I++RD+KP N+++D K ++LID+G A+ + V + + PE++ Sbjct: 646 IEYLHERNIVYRDLKPENILLD-KQGYVKLIDFGCAK--KIQGRAYTLVGTPHYMAPEVI 702 Query: 243 VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQL 281 + + Y ++D+W+ G L I PF G DQL Sbjct: 703 LG-KGYGCTVDIWALGVCLYEFICGPLPF--GNDQEDQL 738 >4AW2-A nrPDB Length = 437 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 60/248 (24%), Positives = 106/248 (42%), Gaps = 52/248 (20%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVI-------KMLKPVKKKKIKREIKILTDLS 90 +D+EI +GRG + EV VKL + K+ +MLK + + E +L + Sbjct: 74 EDFEILKVIGRGAFGEV-AVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGD 132 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 ++ + TTL +Y Q ++ L + Y +++ L +D Sbjct: 133 SKWI--TTL------HYAFQDDNNLYLVMDYYVG------GDLLTLLSKFED-------- 170 Query: 151 VFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 +L + RFY+ E++ A+D H + +HRD+KP N+++D N + Sbjct: 171 ---------------RLPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMD-MNGHI 214 Query: 211 RLIDWG--LAEFYHVNMEYNVRVASRFFKGPELLVDYR----MYDYSLDLWSFGTMLASM 264 RL D+G L ++ +V V + + PE+L Y D WS G + M Sbjct: 215 RLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEGGKGRYGPECDWWSLGVCMYEM 274 Query: 265 IFKREPFF 272 ++ PF+ Sbjct: 275 LYGETPFY 282 >2R2P-A nrPDB Length = 295 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 76/315 (24%), Positives = 131/315 (41%), Gaps = 65/315 (20%) Query: 42 IENKVGRGKYSEVFQG-VKLDSK--VKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTT 98 IE +G G++ EV G +KL K + + IK LK +K +R+ Sbjct: 26 IERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRD---------------- 69 Query: 99 LPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNV 158 F + Q FD P NIIHL ++ SK +V EY++N Sbjct: 70 --FLGEASIMGQ------------FDHP-----NIIHLEGVVTK--SKPVMIVTEYMENG 108 Query: 159 DFRILYPK----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLID 214 K T +++ + + + Y MG +HRD+ N++I+ N ++ D Sbjct: 109 SLDTFLKKNDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILIN-SNLVCKVSD 167 Query: 215 WGLAEFYHVNME--YNVRVASRFFK--GPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 +GL+ + E Y R + PE + +R + + D+WS+G ++ ++ E Sbjct: 168 FGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA-FRKFTSASDVWSYGIVMWEVVSYGER 226 Query: 271 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 330 + +N D ++K V+ E Y L + P Y Q + W + N K Sbjct: 227 PYWEMTNQD-VIKAVE-------EGYRLPSPMDCPAALY---QLMLDCWQKERNSRPKF- 274 Query: 331 SGNDEIIDLIDNLLR 345 DEI++++D L+R Sbjct: 275 ---DEIVNMLDKLIR 286 >3C51-A nrPDB Length = 543 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 35/108 (32%), Positives = 56/108 (51%), Gaps = 3/108 (2%) Query: 165 PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-EFYHV 223 P + FY +++ L++ H I++RD+KP NV++D + +R+ D GLA E Sbjct: 284 PGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDD-DGNVRISDLGLAVELKAG 342 Query: 224 NMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 + + F PELL+ YD+S+D ++ G L MI R PF Sbjct: 343 QTKTKGYAGTPGFMAPELLLGEE-YDFSVDYFALGVTLYEMIAARGPF 389 >2XIK-A nrPDB Length = 294 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 57/233 (24%), Positives = 108/233 (46%), Gaps = 49/233 (21%) Query: 44 NKVGRGKYSEVFQGVKLDSKVKIVIKML----KPVKKKKIKREIKILTDLSNEKVPPTTL 99 +++G+G + EV++G+ +K + IK++ + + I++EI +L+ + Sbjct: 25 DRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS-------- 76 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIK-DPISKTPALVFEYVDNV 158 P+ + + K L I Y+ G A D++K P+ +T Y+ + Sbjct: 77 PYITRYFGSYLKSTKLWIIMEYL----GGGSA-----LDLLKPGPLEET------YIATI 121 Query: 159 DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA 218 + E+LK LDY HS +HRD+K NV++ + ++L D+G+A Sbjct: 122 -----------------LREILKGLDYLHSERKIHRDIKAANVLLSEQG-DVKLADFGVA 163 Query: 219 -EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 + ++ N V + F+ PE ++ YD+ D+WS G + A + K EP Sbjct: 164 GQLTDTQIKRNTFVGTPFWMAPE-VIKQSAYDFKADIWSLG-ITAIELAKGEP 214 >4KIK-B nrPDB Length = 677 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 42/155 (27%), Positives = 69/155 (44%), Gaps = 13/155 (8%) Query: 130 HANIIHLFDIIKD----PISKTPALVFEYVDNVDFRILYPK------LTDLEIRFYMFEL 179 H N++ D+ + + P L EY D R + L + I + ++ Sbjct: 76 HPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDI 135 Query: 180 LKALDYCHSMGIMHRDVKPHNVMIDHKNKKL--RLIDWGLAEFYHVNMEYNVRVASRFFK 237 AL Y H I+HRD+KP N+++ ++L ++ID G A+ V + + Sbjct: 136 ASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYL 195 Query: 238 GPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFF 272 PELL + + Y ++D WSFGT+ I PF Sbjct: 196 APELL-EQQKYTVTVDYWSFGTLAFECITGFRPFL 229 >4FIE-A nrPDB Length = 423 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 52/242 (21%), Positives = 110/242 (45%), Gaps = 50/242 (20%) Query: 130 HANIIHLFD--IIKDPISKTPALVFEYVDNVDFR--ILYPKLTDLEIRFYMFELLKALDY 185 H N++ +++ ++ D + +V E+++ + + ++ + +I +L+AL Sbjct: 207 HENVVEMYNSYLVGDEL----WVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSV 262 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVR---VASRFFKGPELL 242 H+ G++HRD+K ++++ H + +++L D+G V+ E R V + ++ PE L Sbjct: 263 LHAQGVIHRDIKSDSILLTH-DGRVKLSDFGFC--AQVSKEVPRRKSLVGTPYWMAPE-L 318 Query: 243 VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEI 302 + Y +D+WS G M+ M+ P+F+ + +K +K++ + Sbjct: 319 ISRLPYGPEVDIWSLGIMVIEMVDGEPPYFN-----EPPLKAMKMIRDN----------- 362 Query: 303 TLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 LP ++ + + L G +D LL D +R TA E + HP+ Sbjct: 363 -LPPRLKNLHKV------------SPSLKG------FLDRLLVRDPAQRATAAELLKHPF 403 Query: 363 FA 364 A Sbjct: 404 LA 405 >3ORP-A nrPDB Length = 311 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 45/157 (28%), Positives = 75/157 (47%), Gaps = 14/157 (8%) Query: 130 HANIIHLFDI--IKDPISKTPALVFEYVDNVDFR-ILYPK--LTDLEIRFYMFELLKALD 184 H I+ ++D + P P +V EYVD V R I++ + +T + + +AL+ Sbjct: 71 HPAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAIEVIADACQALN 130 Query: 185 YCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFY-----HVNMEYNVRVASRFFKGP 239 + H GI+HRDVKP N+MI N ++++D+G+A V V +++ Sbjct: 131 FSHQNGIIHRDVKPANIMISATN-AVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPE 189 Query: 240 ELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTS 276 + D D D++S G +L + EP F G S Sbjct: 190 QARGDS--VDARSDVYSLGCVLYE-VLTGEPPFTGDS 223 >2JDO-A nrPDB Length = 342 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 91/209 (43%), Gaps = 46/209 (22%) Query: 167 LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-EFYHVNM 225 T+ RFY E++ AL+Y HS +++RD+K N+M+D K+ +++ D+GL E Sbjct: 107 FTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLD-KDGHIKITDFGLCKEGISDGA 165 Query: 226 EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIV 285 + + PE+L D Y ++D W G ++ M+ R PF++ + ++L +++ Sbjct: 166 TMKTFCGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYN--QDHERLFELI 222 Query: 286 KVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLR 345 L EI PR + E L+ LL+ Sbjct: 223 ------------LMEEIRFPRTL------------------------SPEAKSLLAGLLK 246 Query: 346 YDHQERLT-----AKEAMGHPWFAPIREQ 369 D ++RL AKE M H +F I Q Sbjct: 247 KDPKQRLGGGPSDAKEVMEHRFFLSINWQ 275 >4GS6-A nrPDB Length = 315 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 52/226 (23%), Positives = 98/226 (43%), Gaps = 30/226 (13%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVD-FRILY-----PKLTDLEIRFYMFELLKAL 183 H NI+ L+ +P+ LV EY + + +L+ P T + + + + Sbjct: 61 HPNIVKLYGACLNPV----CLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGV 116 Query: 184 DYCHSM---GIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPE 240 Y HSM ++HRD+KP N+++ L++ D+G A +M N A+ + PE Sbjct: 117 AYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAA--WMAPE 174 Query: 241 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 300 + + Y D++S+G +L +I +R+PF D+ +G F + Sbjct: 175 VF-EGSNYSEKCDVFSWGIILWEVITRRKPF-------DE-------IGGPAFRIMWAVH 219 Query: 301 EITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRY 346 T P ++ + I R + +EI+ ++ +L+RY Sbjct: 220 NGTRPPLIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRY 265 >3M42-A nrPDB Length = 299 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 52/200 (26%), Positives = 78/200 (39%), Gaps = 58/200 (29%) Query: 168 TDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK--NKKLRLIDWGLAEFYHVNM 225 T+ E M + +A+ Y HS+ I HRDVKP N++ K N L+L D+G A+ Sbjct: 115 TEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKE----- 169 Query: 226 EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFF--HGTSNTDQLVK 283 YD S D+WS G ++ ++ PF+ HG + + Sbjct: 170 -----------------TTGEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISP---- 208 Query: 284 IVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNL 343 M IR + F N +S +E+ LI NL Sbjct: 209 --------------------------GMKTRIRMGQYEFPNPEWSEVS--EEVKMLIRNL 240 Query: 344 LRYDHQERLTAKEAMGHPWF 363 L+ + +R+T E M HPW Sbjct: 241 LKTEPTQRMTITEFMNHPWI 260 >5HI2-A nrPDB Length = 283 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 57/289 (19%), Positives = 114/289 (39%), Gaps = 65/289 (22%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSN 91 DW + ++G G + V++G + +KML P + + K E+ +L Sbjct: 14 DWEIPDGQITVGQRIGSGSFGTVYKG---KWHGDVAVKMLTPQQLQAFKNEVGVLRKTR- 69 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H NI+ P A+V Sbjct: 70 --------------------------------------HVNILLFMGYSTKP---QLAIV 88 Query: 152 FEYVDNVDFRILYPKLTDLEIRFYMFELL-------KALDYCHSMGIMHRDVKPHNVMID 204 ++ + LY L E +F M +L+ + +DY H+ I+HRD+K +N+ + Sbjct: 89 TQWCEGSS---LYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFL- 144 Query: 205 HKNKKLRLIDWGLAEF---YHVNMEYNVRVASRFFKGPEL--LVDYRMYDYSLDLWSFGT 259 H++ +++ D+GLA + + ++ S + PE+ + D Y + D+++FG Sbjct: 145 HEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDSNPYSFQSDVYAFGI 204 Query: 260 MLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREF 308 +L ++ + P+ SN + +I++++G L K P+ Sbjct: 205 VLYELMTGQLPY----SNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRM 249 >2WTK-C nrPDB Length = 305 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 52/217 (23%), Positives = 94/217 (43%), Gaps = 38/217 (17%) Query: 130 HANIIHLFDIIKDPISKTPALVFEY--------VDNVDFRILYPKLTDLEIRFYMFELLK 181 H N+I L D++ + + +V EY +D+V + + + Y +L+ Sbjct: 65 HKNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK----RFPVCQAHGYFCQLID 120 Query: 182 ALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYH---VNMEYNVRVASRFFKG 238 L+Y HS GI+H+D+KP N+++ L++ G+AE H + S F+ Sbjct: 121 GLEYLHSQGIVHKDIKPGNLLLT-TGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQP 179 Query: 239 PELLVDYRMYD-YSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGT------- 290 PE+ + + +D+WS G L ++ PF D + K+ + +G Sbjct: 180 PEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPF-----EGDNIYKLFENIGKGSYAIPG 234 Query: 291 ------SDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 SD K +L+YE P + + + Q + W R Sbjct: 235 DCGPPLSDLLKGMLEYE---PAKRFSIRQIRQHSWFR 268 >6E2O-A nrPDB Length = 295 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 61/270 (22%), Positives = 110/270 (40%), Gaps = 60/270 (22%) Query: 18 QRTEEYWDYENTVIDWSTNTKDYEIENK-----VGRGKYSEVFQGVKLDSKVKIVIKMLK 72 R+ E D E+ ++++ DYE + +G+G Y V+ G L ++V+I IK Sbjct: 2 SRSTEEGDCESDLLEY-----DYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIK--- 53 Query: 73 PVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHAN 132 ++P ++D Y+ + + + H H N Sbjct: 54 --------------------EIP------ERDSRYSQPLHEEIALHK-------HLKHKN 80 Query: 133 IIHLFD------IIKDPISKTPALVFEYVDNVDFRILYPKLTDLE--IRFYMFELLKALD 184 I+ IK + + P + R + L D E I FY ++L+ L Sbjct: 81 IVQYLGSFSENGFIKIFMEQVPGGSLSAL----LRSKWGPLKDNEQTIGFYTKQILEGLK 136 Query: 185 YCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAE-FYHVNMEYNVRVASRFFKGPELL- 242 Y H I+HRD+K NV+I+ + L++ D+G ++ +N + + PE++ Sbjct: 137 YLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIID 196 Query: 243 VDYRMYDYSLDLWSFGTMLASMIFKREPFF 272 R Y + D+WS G + M + PF+ Sbjct: 197 KGPRGYGKAADIWSLGCTIIEMATGKPPFY 226 >5LOH-A nrPDB Length = 341 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 68/245 (27%), Positives = 111/245 (45%), Gaps = 51/245 (20%) Query: 133 IIHLFDIIKDPISKTPALVFEYVDNVDFRIL---YPKLTDLEIRFYMFELLKALDYCHSM 189 I+HL+ ++ + LV EY+ D + L Y + Y+ E+ ALDY H Sbjct: 96 IVHLYYSLQS--ANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRH 153 Query: 190 GIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVR--VASRFFKG------PEL 241 GI+HRD+KP N++I ++ ++L D+GL++ +N + N+ + +R F G PEL Sbjct: 154 GIIHRDLKPDNMLISNEG-HIKLTDFGLSKVT-LNRDINMMDILTTRTFCGTPDYLAPEL 211 Query: 242 LVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYE 301 L+ R + ++D W+ G L + PF T Q V F+ +LK + Sbjct: 212 LLG-RAHGPAVDWWALGVCLFEFLTGIPPF---NDETPQQV----------FQN-ILKRD 256 Query: 302 ITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHP 361 I PW +G + LS N + ++ LL D +R KE HP Sbjct: 257 I---------------PW----PEGEEKLSDNAQ--SAVEILLTIDDTKRAGMKELKRHP 295 Query: 362 WFAPI 366 F+ + Sbjct: 296 LFSDV 300 >3IS5-A nrPDB Length = 285 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 51/243 (20%), Positives = 103/243 (42%), Gaps = 48/243 (19%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDF--RILYPK-----LTDLEIRFYMFELLKA 182 H NII +F++ +D +V E + + RI+ + L++ + M +++ A Sbjct: 79 HPNIIKIFEVFED--YHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNA 136 Query: 183 LDYCHSMGIMHRDVKPHNVMIDHKN--KKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPE 240 L Y HS ++H+D+KP N++ + +++ID+GLAE + + + + PE Sbjct: 137 LAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPE 196 Query: 241 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 300 + R + D+WS G ++ ++ PF GTS Sbjct: 197 VF--KRDVTFKCDIWSAGVVMYFLLTGCLPF----------------TGTS--------- 229 Query: 301 EITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGH 360 +++ +K ++ N + + +DL+ +L D + R +A + + H Sbjct: 230 ----------LEEVQQKATYKEPNYAVECRPLTPQAVDLLKQMLTKDPERRPSAAQVLHH 279 Query: 361 PWF 363 WF Sbjct: 280 EWF 282 >3NYO-A nrPDB Length = 576 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 32/98 (32%), Positives = 52/98 (53%), Gaps = 2/98 (2%) Query: 174 FYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVAS 233 FY E+ L+ H I++RD+KP N+++D + +R+ D GLA RV + Sbjct: 290 FYAAEICCGLEDLHRERIVYRDLKPENILLDD-HGHIRISDLGLAVHVPEGQTIKGRVGT 348 Query: 234 RFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 + PE++ + R Y +S D W+ G +L MI + PF Sbjct: 349 VGYMAPEVVKNER-YTFSPDWWALGCLLYEMIAGQSPF 385 >2PZI-A nrPDB Length = 681 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 66/254 (25%), Positives = 109/254 (42%), Gaps = 39/254 (15%) Query: 130 HANIIHLFDIIK------DPISKTPALVFEYVDNVDF-RILYPKLTDLEIRFYMFELLKA 182 H +I+ +F+ ++ DP+ +V EYV R KL E Y+ E+L A Sbjct: 138 HPSIVQIFNFVEHTDRHGDPVGY---IVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPA 194 Query: 183 LDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELL 242 L Y HS+G+++ D+KP N+M+ ++L+LID G +N + + F+ PE++ Sbjct: 195 LSYLHSIGLVYNDLKPENIML--TEEQLKLIDLG--AVSRIN-SFGYLYGTPGFQAPEIV 249 Query: 243 VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEI 302 + D+++ G LA++ P +G D L + VL T D LL+ I Sbjct: 250 --RTGPTVATDIYTVGRTLAALTLDL-PTRNG-RYVDGLPEDDPVLKTYDSYGRLLRRAI 305 Query: 303 -------------------TLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNL 343 + RE D + +P I ++ G D ++ D Sbjct: 306 DPDPRQRFTTAEEMSAQLTGVLREVVAQDTGVPRPGLSTIFSPSRSTFGVDLLVAHTDVY 365 Query: 344 LRYD-HQERLTAKE 356 L H E+LTA E Sbjct: 366 LDGQVHAEKLTANE 379 >2Q0N-A nrPDB Length = 301 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 52/242 (21%), Positives = 110/242 (45%), Gaps = 50/242 (20%) Query: 130 HANIIHLFD--IIKDPISKTPALVFEYVDNVDFR--ILYPKLTDLEIRFYMFELLKALDY 185 H N++ +++ ++ D + +V E+++ + + ++ + +I +L+AL Sbjct: 85 HENVVEMYNSYLVGDEL----WVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSV 140 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVR---VASRFFKGPELL 242 H+ G++HRD+K ++++ H + +++L D+G V+ E R V + ++ PE L Sbjct: 141 LHAQGVIHRDIKSDSILLTH-DGRVKLSDFGFCA--QVSKEVPRRKSLVGTPYWMAPE-L 196 Query: 243 VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEI 302 + Y +D+WS G M+ M+ P+F+ + +K +K++ + Sbjct: 197 ISRLPYGPEVDIWSLGIMVIEMVDGEPPYFN-----EPPLKAMKMIRDN----------- 240 Query: 303 TLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 LP ++ + + L G +D LL D +R TA E + HP+ Sbjct: 241 -LPPRLKNLHKV------------SPSLKG------FLDRLLVRDPAQRATAAELLKHPF 281 Query: 363 FA 364 A Sbjct: 282 LA 283 >4JDH-A nrPDB Length = 346 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 52/242 (21%), Positives = 110/242 (45%), Gaps = 50/242 (20%) Query: 130 HANIIHLFD--IIKDPISKTPALVFEYVDNVDFR--ILYPKLTDLEIRFYMFELLKALDY 185 H N++ +++ ++ D + +V E+++ + + ++ + +I +L+AL Sbjct: 130 HENVVEMYNSYLVGDEL----WVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSV 185 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVR---VASRFFKGPELL 242 H+ G++HRD+K ++++ H + +++L D+G V+ E R V + ++ PE L Sbjct: 186 LHAQGVIHRDIKSDSILLTH-DGRVKLSDFGFCA--QVSKEVPRRKSLVGTPYWMAPE-L 241 Query: 243 VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEI 302 + Y +D+WS G M+ M+ P+F+ + +K +K++ + Sbjct: 242 ISRLPYGPEVDIWSLGIMVIEMVDGEPPYFN-----EPPLKAMKMIRDN----------- 285 Query: 303 TLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 LP ++ + + L G +D LL D +R TA E + HP+ Sbjct: 286 -LPPRLKNLHKV------------SPSLKG------FLDRLLVRDPAQRATAAELLKHPF 326 Query: 363 FA 364 A Sbjct: 327 LA 328 >5KCV-A nrPDB Length = 460 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 54/201 (26%), Positives = 88/201 (43%), Gaps = 47/201 (23%) Query: 173 RFYMFELLKALDYCHS-MGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-EFYHVNMEYNVR 230 RFY E++ ALDY HS +++RD+K N+M+D K+ +++ D+GL E Sbjct: 265 RFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-KDGHIKITDFGLCKEGIKDGATMKTF 323 Query: 231 VASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGT 290 + + PE+L D Y ++D W G ++ M+ R PF++ + ++L +++ Sbjct: 324 CGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMCGRLPFYN--QDHEKLFELI----- 375 Query: 291 SDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQE 350 L EI PR E L+ LL+ D ++ Sbjct: 376 -------LMEEIRFPRTL------------------------GPEAKSLLSGLLKKDPKQ 404 Query: 351 RLT-----AKEAMGHPWFAPI 366 RL AKE M H +FA I Sbjct: 405 RLGGGSEDAKEIMQHRFFAGI 425 >6HXF-B nrPDB Length = 302 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 39/125 (31%), Positives = 69/125 (55%), Gaps = 7/125 (5%) Query: 167 LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGL-AEFYHVNM 225 LT+ +I+ ++L+AL++ HS I+HRD+K NV++ + +RL D+G+ A+ Sbjct: 114 LTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEG-DIRLADFGVSAKNLKTLQ 172 Query: 226 EYNVRVASRFFKGPELLVDYRM----YDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQL 281 + + + + ++ PE+++ M YDY D+WS G L M + EP H + L Sbjct: 173 KRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMA-QIEPPHHELNPMRVL 231 Query: 282 VKIVK 286 +KI K Sbjct: 232 LKIAK 236 >6FYV-A nrPDB Length = 337 Score = 57.8 bits (138), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 72/364 (19%), Positives = 160/364 (43%), Gaps = 87/364 (23%) Query: 40 YEIENKVGRGKYSEVFQGV--KLDSKVKIVIKMLKPVKK--KKIKREIKILTDLSNEKVP 95 YEI + +G G + +V + + +D + + +K++K V + + + EI++L L++ Sbjct: 16 YEIVDTLGEGAFGKVVECIDHGMDG-MHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPN 74 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIK----DPISKTPALV 151 Q +++ H+GH I+ F+++ D I + L Sbjct: 75 SVFRCVQMLEWFD------------------HHGHVCIV--FELLGLSTYDFIKENSFLP 114 Query: 152 FEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI-------- 203 F+ +D+ IR +++ +++++ H + H D+KP N++ Sbjct: 115 FQ-IDH--------------IRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVK 159 Query: 204 ----------DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLD 253 KN ++++D+G A + + ++ V++R ++ PE+++ + D Sbjct: 160 YNSKMKRDERTLKNTDIKVVDFGSATY--DDEHHSTLVSTRHYRAPEVILALG-WSQPCD 216 Query: 254 LWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQ 313 +WS G +L F + + L + ++LG +++++ T R+++ +Q Sbjct: 217 VWSIGCILIEYYLGF-TVFQTHDSKEHLAMMERILGP--IPQHMIQK--TRKRKYFHHNQ 271 Query: 314 -----------YIR---KPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMG 359 Y+R KP F+ H ++++ DL+ +L YD +R+T EA+ Sbjct: 272 LDWDEHSSAGRYVRRRCKPLKEFML---CHDEEHEKLFDLVRRMLEYDPTQRITLDEALQ 328 Query: 360 HPWF 363 HP+F Sbjct: 329 HPFF 332 >4XBR-A nrPDB Length = 366 Score = 57.8 bits (138), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 52/242 (21%), Positives = 110/242 (45%), Gaps = 50/242 (20%) Query: 130 HANIIHLFD--IIKDPISKTPALVFEYVDNVDFR--ILYPKLTDLEIRFYMFELLKALDY 185 H N++ +++ ++ D + +V E+++ + + ++ + +I +L+AL Sbjct: 150 HENVVEMYNSYLVGDEL----WVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSV 205 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVR---VASRFFKGPELL 242 H+ G++HRD+K ++++ H + +++L D+G V+ E R V + ++ PE L Sbjct: 206 LHAQGVIHRDIKSDSILLTH-DGRVKLSDFGFCA--QVSKEVPRRKSLVGTPYWMAPE-L 261 Query: 243 VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEI 302 + Y +D+WS G M+ M+ P+F+ + +K +K++ + Sbjct: 262 ISRLPYGPEVDIWSLGIMVIEMVDGEPPYFN-----EPPLKAMKMIRDN----------- 305 Query: 303 TLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 LP ++ + + L G +D LL D +R TA E + HP+ Sbjct: 306 -LPPRLKNLHKV------------SPSLKG------FLDRLLVRDPAQRATAAELLKHPF 346 Query: 363 FA 364 A Sbjct: 347 LA 348 >4KS7-A nrPDB Length = 292 Score = 57.8 bits (138), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 47/199 (23%), Positives = 91/199 (45%), Gaps = 38/199 (19%) Query: 166 KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWG-LAEFYHVN 224 +L + +I +L+AL Y H+ G++HRD+K ++++ + +++L D+G A+ Sbjct: 115 RLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLT-LDGRVKLSDFGFCAQISKDV 173 Query: 225 MEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKI 284 + V + ++ PE ++ +Y +D+WS G M+ M+ P+F +D V+ Sbjct: 174 PKRKSLVGTPYWMAPE-VISRSLYATEVDIWSLGIMVIEMVDGEPPYF-----SDSPVQA 227 Query: 285 VKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLL 344 +K L S K ++++ P R D ++ +L Sbjct: 228 MKRLRDSPPPKLKNSHKVS--------------PVLR----------------DFLERML 257 Query: 345 RYDHQERLTAKEAMGHPWF 363 D QER TA+E + HP+ Sbjct: 258 VRDPQERATAQELLDHPFL 276 >4P5Q-A nrPDB Length = 361 Score = 57.8 bits (138), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 80/331 (24%), Positives = 132/331 (39%), Gaps = 61/331 (18%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVP 95 + + I+ VG G++ EV G LK KK+I IK L Sbjct: 31 DATNISIDKVVGAGEFGEVCSG------------RLKLPSKKEISVAIKTL--------- 69 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 K Y Q+ D L I Q H NII L ++ SK +V EY+ Sbjct: 70 -------KVGYTEKQRRDFLG--EASIMGQFD--HPNIIRLEGVVTK--SKPVMIVTEYM 116 Query: 156 DNVDFRILYPK----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 +N K T +++ + + + Y MG +HRD+ N++I+ N + Sbjct: 117 ENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILIN-SNLVCK 175 Query: 212 LIDWGLAEFYHVNME--YNVRVASRFFK--GPELLVDYRMYDYSLDLWSFGTML-ASMIF 266 + D+GL+ + E Y R + PE + YR + + D+WS+G +L M + Sbjct: 176 VSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIA-YRKFTSASDVWSYGIVLWEVMSY 234 Query: 267 KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG 326 P++ SN D ++K V E Y L + P Y Q + W + N+ Sbjct: 235 GERPYWE-MSNQD-VIKAVD-------EGYRLPPPMDCPAALY---QLMLDCWQKDRNNR 282 Query: 327 NKHLSGNDEIIDLIDNLLRYDHQERLTAKEA 357 K ++I+ ++D L+R ++ A Sbjct: 283 PKF----EQIVSILDKLIRNPGSLKIITSAA 309 >3MV5-A nrPDB Length = 342 Score = 57.8 bits (138), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 80/345 (23%), Positives = 137/345 (39%), Gaps = 81/345 (23%) Query: 30 VIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDL 89 +D ++E +G+G + +V + + K +K +KK+ I + ++ L Sbjct: 2 AMDPRVTMNEFEYLKLLGKGTFGKV---ILVKEKATGRYYAMKILKKEVIVAKDEVAHTL 58 Query: 90 SNEKVPPTTL-PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTP 148 + +V + PF Y+ Q D L F+ Y NG HL + Sbjct: 59 TENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYA-----NGGELFFHL----------SR 103 Query: 149 ALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHS-MGIMHRDVKPHNVMIDHKN 207 VF ++ RFY E++ ALDY HS +++RD+K N+M+D K+ Sbjct: 104 ERVF---------------SEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-KD 147 Query: 208 KKLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 +++ D+GL E + + PE+L D Y ++D W G ++ M+ Sbjct: 148 GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLED-NDYGRAVDWWGLGVVMYEMMC 206 Query: 267 KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG 326 R PF++ + ++L +++ L EI PR Sbjct: 207 GRLPFYN--QDHEKLFELI------------LMEEIRFPRTL------------------ 234 Query: 327 NKHLSGNDEIIDLIDNLLRYDHQERLT-----AKEAMGHPWFAPI 366 E L+ LL+ D ++RL AKE M H +FA I Sbjct: 235 ------GPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGI 273 >5DBX-A nrPDB Length = 328 Score = 57.4 bits (137), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 30/106 (28%), Positives = 55/106 (51%), Gaps = 7/106 (6%) Query: 172 IRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYN--- 228 I + E+L+ LDY H G +HRD+K N+++ ++ +++ D+G++ F + Sbjct: 119 IATILKEVLEGLDYLHRNGQIHRDLKAGNILLG-EDGSVQIADFGVSAFLATGGDVTRNK 177 Query: 229 VR---VASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 VR V + + PE++ R YD+ D+WSFG + P+ Sbjct: 178 VRKDFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPY 223 >3TKU-A nrPDB Length = 433 Score = 57.4 bits (137), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 41/133 (30%), Positives = 63/133 (47%), Gaps = 11/133 (8%) Query: 150 LVFEYVDNVDFRILYPKLTDL----EIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 LV +Y D L K D RFY+ E++ A+D H + +HRD+KP NV++D Sbjct: 167 LVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLD- 225 Query: 206 KNKKLRLIDWG--LAEFYHVNMEYNVRVASRFFKGPELLVDYR----MYDYSLDLWSFGT 259 N +RL D+G L ++ +V V + + PE+L Y D WS G Sbjct: 226 VNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGV 285 Query: 260 MLASMIFKREPFF 272 + M++ PF+ Sbjct: 286 CMYEMLYGETPFY 298 >3VN9-A nrPDB Length = 340 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 42/192 (21%), Positives = 82/192 (42%), Gaps = 42/192 (21%) Query: 178 ELLKALDYCHS-MGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFF 236 ++KAL++ HS + ++HRDVKP NV+I+ ++++ D+G++ + ++ + + + Sbjct: 161 SIVKALEHLHSKLSVIHRDVKPSNVLINALG-QVKMCDFGISGYLVDSVAKTIDAGCKPY 219 Query: 237 KGPELL---VDYRMYDYSLDLWSFGTMLASMIFKREPFFH-GTSNTDQLVKIVKVLGTSD 292 PE + ++ + Y D+WS G + + R P+ GT Sbjct: 220 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP---------------- 263 Query: 293 FEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERL 352 F + Q + +P + D + E +D L+ + +ER Sbjct: 264 ---------------FQQLKQVVEEPSPQLPAD-----KFSAEFVDFTSQCLKKNSKERP 303 Query: 353 TAKEAMGHPWFA 364 T E M HP+F Sbjct: 304 TYPELMQHPFFT 315 >3DLS-A nrPDB Length = 335 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 40/146 (27%), Positives = 72/146 (49%), Gaps = 7/146 (4%) Query: 130 HANIIHLFDIIKDPISKTPALVFE----YVDNVDFRILYPKLTDLEIRFYMFELLKALDY 185 HANII + DI ++ LV E +D F +P+L + + +L+ A+ Y Sbjct: 88 HANIIKVLDIFEN--QGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGY 145 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDY 245 I+HRD+K N++I ++ ++LID+G A + + + + PE+L+ Sbjct: 146 LRLKDIIHRDIKDENIVI-AEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGN 204 Query: 246 RMYDYSLDLWSFGTMLASMIFKREPF 271 L++WS G L +++F+ PF Sbjct: 205 PYRGPELEMWSLGVTLYTLVFEENPF 230 >3TXO-A nrPDB Length = 353 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 39/140 (27%), Positives = 68/140 (48%), Gaps = 8/140 (5%) Query: 150 LVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK 206 V E+V+ D K + RFY E++ AL + H GI++RD+K NV++DH+ Sbjct: 101 FVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHE 160 Query: 207 NKKLRLIDWGLAEFYHVN-MEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 +L D+G+ + N + + + PE+L + +Y ++D W+ G +L M+ Sbjct: 161 G-HCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEM-LYGPAVDWWAMGVLLYEML 218 Query: 266 FKREPFFHGTSNTDQLVKIV 285 PF N D L + + Sbjct: 219 CGHAPF--EAENEDDLFEAI 236 >4Y12-A nrPDB Length = 375 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 40/144 (27%), Positives = 72/144 (50%), Gaps = 17/144 (11%) Query: 130 HANIIHLFDIIK------DPISKTPALVFEYVDNVDF-RILYPKLTDLEIRFYMFELLKA 182 H +I+ +F+ ++ DP+ +V EYV R KL E Y+ E+L A Sbjct: 177 HPSIVQIFNFVEHTDRHGDPVGY---IVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPA 233 Query: 183 LDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELL 242 L Y HS+G+++ D+KP N+M+ ++L+LID G +N + + F+ PE++ Sbjct: 234 LSYLHSIGLVYNDLKPENIML--TEEQLKLIDLGAVS--RIN-SFGYLYGTPGFQAPEIV 288 Query: 243 VDYRMYDYSLDLWSFGTMLASMIF 266 + D+++ G LA++ Sbjct: 289 --RTGPTVATDIYTVGRTLAALTL 310 >1VZO-A nrPDB Length = 355 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 56/242 (23%), Positives = 101/242 (41%), Gaps = 37/242 (15%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVP 95 +++E+ +G G Y +VF K+ + +K +KK I ++ K E+ Sbjct: 52 GIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQV 111 Query: 96 PTTL---PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF 152 + PF +Y Q E L I YI NG HL Sbjct: 112 LEHIRQSPFLVTLHYAFQTETKLHLILDYI-----NGGELFTHLSQ-------------- 152 Query: 153 EYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRL 212 + T+ E++ Y+ E++ AL++ H +GI++RD+K N+++D N + L Sbjct: 153 -----------RERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLD-SNGHVVL 200 Query: 213 IDWGLA-EFYHVNMEYNVRVASRF-FKGPELLVDY-RMYDYSLDLWSFGTMLASMIFKRE 269 D+GL+ EF E + P+++ +D ++D WS G ++ ++ Sbjct: 201 TDFGLSKEFVADETERAYDFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGAS 260 Query: 270 PF 271 PF Sbjct: 261 PF 262 >4FR4-A nrPDB Length = 384 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 54/265 (20%), Positives = 118/265 (44%), Gaps = 49/265 (18%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML---KPVKKKKIK---REIKILTD 88 N +EI +G+G + +V K D+K +K + K V++ +++ +E++I+ Sbjct: 12 VNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQG 71 Query: 89 LSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTP 148 L + PF + +Y+ Q E+ ++ + D++ Sbjct: 72 LEH--------PFLVNLWYSFQDEE------------------DMFMVVDLLL-----GG 100 Query: 149 ALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK 208 L + NV F+ + ++ ++ EL+ ALDY + I+HRD+KP N+++D ++ Sbjct: 101 DLRYHLQQNVHFK-------EETVKLFICELVMALDYLQNQRIIHRDMKPDNILLD-EHG 152 Query: 209 KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYR--MYDYSLDLWSFGTMLASMIF 266 + + D+ +A + ++ + PE+ + Y +++D WS G ++ Sbjct: 153 HVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYELLR 212 Query: 267 KREPFFHGTSNTDQLVKIVKVLGTS 291 R P+ +S + + +IV T+ Sbjct: 213 GRRPYHIRSSTSSK--EIVHTFETT 235 >5N23-A nrPDB Length = 352 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 44/204 (21%), Positives = 91/204 (44%), Gaps = 46/204 (22%) Query: 166 KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNM 225 + ++ RFY +++ +Y HS+ +++RD+KP N++ID + +++ D+G A+ Sbjct: 138 RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG-YIKVADFGFAKRVKGRT 196 Query: 226 EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIV 285 + + + PE+++ + Y+ ++D W+ G ++ M PFF DQ ++I Sbjct: 197 PWTLCGTPEYL-APEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF-----ADQPIQI- 248 Query: 286 KVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLR 345 +EK ++ ++ P F + ++ DL+ NLL+ Sbjct: 249 -------YEK-IVSGKVRFPSHF------------------------SSDLKDLLRNLLQ 276 Query: 346 YDHQERL-----TAKEAMGHPWFA 364 D +R + H WFA Sbjct: 277 VDLTKRFGNLKNGVNDIKNHKWFA 300 >3FME-A nrPDB Length = 290 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 41/191 (21%), Positives = 85/191 (44%), Gaps = 40/191 (20%) Query: 178 ELLKALDYCHS-MGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFF 236 ++KAL++ HS + ++HRDVKP NV+I+ ++++ D+G++ + ++ ++ + + Sbjct: 117 SIVKALEHLHSKLSVIHRDVKPSNVLINALG-QVKMCDFGISGYLVDDVAKDIDAGCKPY 175 Query: 237 KGPELL---VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDF 293 PE + ++ + Y D+WS G + + R P+ + QL ++V+ Sbjct: 176 MAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE------- 228 Query: 294 EKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLT 353 + + P +F + E +D L+ + +ER T Sbjct: 229 ------------------EPSPQLPADKF----------SAEFVDFTSQCLKKNSKERPT 260 Query: 354 AKEAMGHPWFA 364 E M HP+F Sbjct: 261 YPELMQHPFFT 271 >4FZF-B nrPDB Length = 283 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 33/103 (32%), Positives = 56/103 (54%), Gaps = 4/103 (3%) Query: 169 DLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-EFYHVNMEY 227 + +I + E+LK LDY HS +HRD+K NV++ + ++L +G+A + ++ Sbjct: 104 EFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQG-DVKLAAFGVAGQLTDTQIKR 162 Query: 228 NVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 N V + F+ PE ++ YD D+WS G + A + K EP Sbjct: 163 NTFVGTPFWMAPE-VIQQSAYDSKADIWSLG-ITAIELAKGEP 203 >4EBW-A nrPDB Length = 304 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 59/265 (22%), Positives = 106/265 (40%), Gaps = 52/265 (19%) Query: 34 STNTKDYEIENK-------VGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKIL 86 ++T+DYEI+ + +G G++ +V QG+ + + P IK Sbjct: 27 GSSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPE--------NPALAVAIKTCKNCT 78 Query: 87 TDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII-KDPIS 145 +D EK F ++ Q FD PH I+ L +I ++P+ Sbjct: 79 SDSVREK-------FLQEALTMRQ------------FDHPH-----IVKLIGVITENPV- 113 Query: 146 KTPALVFEYVDNVDFRILYP----KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNV 201 ++ E + R L + Y ++L AL Y S +HRD+ NV Sbjct: 114 ---WIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNV 170 Query: 202 MIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFK--GPELLVDYRMYDYSLDLWSFGT 259 ++ N ++L D+GL+ + + Y K PE +++R + + D+W FG Sbjct: 171 LVS-SNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPE-SINFRRFTSASDVWMFGV 228 Query: 260 MLASMIFKREPFFHGTSNTDQLVKI 284 + ++ F G N D + +I Sbjct: 229 CMWEILMHGVKPFQGVKNNDVIGRI 253 >6FD3-A nrPDB Length = 300 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 29/104 (27%), Positives = 55/104 (52%), Gaps = 3/104 (2%) Query: 171 EIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWG-LAEFYHVNMEYNV 229 +I E L+ALD+ HS ++HRD+K N+++ + ++L D+G A+ + + Sbjct: 119 QIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGM-DGSVKLTDFGFCAQITPEQSKRST 177 Query: 230 RVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFH 273 V + ++ PE +V + Y +D+WS G M M+ P+ + Sbjct: 178 MVGTPYWMAPE-VVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLN 220 >4WB7-A nrPDB Length = 405 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 45/204 (22%), Positives = 91/204 (44%), Gaps = 47/204 (23%) Query: 166 KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNM 225 + ++ RFY +++ +Y HS+ +++RD+KP N++ID + +++ D+G A+ V Sbjct: 192 RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG-YIQVTDFGFAK--RVKG 248 Query: 226 EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIV 285 + + PE+++ + Y+ ++D W+ G ++ M PFF DQ ++I Sbjct: 249 RTWTLCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF-----ADQPIQI- 301 Query: 286 KVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLR 345 +EK ++ ++ P F + ++ DL+ NLL+ Sbjct: 302 -------YEK-IVSGKVRFPSHF------------------------SSDLKDLLRNLLQ 329 Query: 346 YDHQERL-----TAKEAMGHPWFA 364 D +R + H WFA Sbjct: 330 VDLTKRFGNLKNGVNDIKNHKWFA 353 >5X3F-B nrPDB Length = 393 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 45/204 (22%), Positives = 91/204 (44%), Gaps = 47/204 (23%) Query: 166 KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNM 225 + ++ RFY +++ +Y HS+ +++RD+KP N++ID + +++ D+G A+ V Sbjct: 180 RFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQG-YIQVTDFGFAK--RVKG 236 Query: 226 EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIV 285 + + PE+++ + Y+ ++D W+ G ++ M PFF DQ ++I Sbjct: 237 RTWTLCGTPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF-----ADQPIQI- 289 Query: 286 KVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLR 345 +EK ++ ++ P F + ++ DL+ NLL+ Sbjct: 290 -------YEK-IVSGKVRFPSHF------------------------SSDLKDLLRNLLQ 317 Query: 346 YDHQERL-----TAKEAMGHPWFA 364 D +R + H WFA Sbjct: 318 VDLTKRFGNLKNGVNDIKNHKWFA 341 >5HIE-A nrPDB Length = 302 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 54/266 (20%), Positives = 110/266 (41%), Gaps = 62/266 (23%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSN 91 DW + ++G G + V++G + +KML P + + K E+ +L Sbjct: 30 DWEIPDGQITVGQRIGSGSFGTVYKG---KWHGDVAVKMLTPQQLQAFKNEVGVLRKTR- 85 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H NI+ P A+V Sbjct: 86 --------------------------------------HVNILLFMGYSTKP---QLAIV 104 Query: 152 FEYVDNVDFRILYPKLTDLEIRFYMFELL-------KALDYCHSMGIMHRDVKPHNVMID 204 ++ + LY L +E +F M +L+ + +DY H+ I+HRD+K +N+ + Sbjct: 105 TQWCEGSS---LYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFL- 160 Query: 205 HKNKKLRLIDWGLAEF---YHVNMEYNVRVASRFFKGPEL--LVDYRMYDYSLDLWSFGT 259 H++ +++ D+GLA + + ++ S + PE+ + D Y + D+++FG Sbjct: 161 HEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGI 220 Query: 260 MLASMIFKREPFFHGTSNTDQLVKIV 285 +L ++ + P+ + +N DQ++ +V Sbjct: 221 VLYELMTGQLPYSN-INNRDQIIFMV 245 >2F57-A nrPDB Length = 317 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 46/219 (21%), Positives = 96/219 (43%), Gaps = 44/219 (20%) Query: 150 LVFEYVDNVDFR--ILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN 207 +V E+++ + + ++ + +I +L+AL Y H+ G++HRD+K ++++ + Sbjct: 119 VVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLT-SD 177 Query: 208 KKLRLIDWGLAEFYHVNMEYNVR---VASRFFKGPELLVDYRMYDYSLDLWSFGTMLASM 264 +++L D+G V+ E R V + ++ PE ++ Y +D+WS G M+ M Sbjct: 178 GRIKLSDFGFCA--QVSKEVPKRKSLVGTPYWMAPE-VISRLPYGTEVDIWSLGIMVIEM 234 Query: 265 IFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIN 324 I P+F N L + + + +LP D+ + Sbjct: 235 IDGEPPYF----NEPPL-------------QAMRRIRDSLPPRVKDLHKV---------- 267 Query: 325 DGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + + +D +L + +R TA+E +GHP+ Sbjct: 268 --------SSVLRGFLDLMLVREPSQRATAQELLGHPFL 298 >4RA4-A nrPDB Length = 355 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 39/133 (29%), Positives = 70/133 (52%), Gaps = 20/133 (15%) Query: 150 LVFEYVDNVDFRILY-----PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID 204 V EYV+ D ++Y K + + FY E+ L + H GI++RD+K NVM+D Sbjct: 98 FVMEYVNGGD--LMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLD 155 Query: 205 HKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKG------PELLVDYRMYDYSLDLWSFG 258 + +++ D+G+ + + ++ V +R F G PE++ Y+ Y S+D W++G Sbjct: 156 SEG-HIKIADFGMCKEHMMD-----GVTTRTFCGTPDYIAPEIIA-YQPYGKSVDWWAYG 208 Query: 259 TMLASMIFKREPF 271 +L M+ + PF Sbjct: 209 VLLYEMLAGQPPF 221 >4I6B-A nrPDB Length = 308 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 32/107 (29%), Positives = 62/107 (57%), Gaps = 5/107 (4%) Query: 167 LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME 226 LT+ E+R+Y+ +++ L Y H I+HRD+K N I+ ++ +L++ D+GLA +E Sbjct: 125 LTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFIN-ESMELKVGDFGLAARLE-PLE 182 Query: 227 YNVR--VASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 + R + + PE+L + + + D+W+ G ++ +M+ R PF Sbjct: 183 HRRRTICGTPNYLSPEVL-NKQGHGAESDIWALGCVMYTMLLGRPPF 228 >4E20-A nrPDB Length = 290 Score = 55.5 bits (132), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 46/186 (24%), Positives = 87/186 (46%), Gaps = 20/186 (10%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMF--ELLKALDYCH 187 H +I+ +D K+ LV EYV R P+ + +F ++ + + Y H Sbjct: 69 HEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEGMAYLH 128 Query: 188 SMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-------EFYHVNMEYNVRVASRFFKGPE 240 + +HR + NV++D+ ++ +++ D+GLA E+Y V + + V F+ PE Sbjct: 129 AQHYIHRALAARNVLLDN-DRLVKIGDFGLAKAVPEGHEYYRVREDGDSPV---FWYAPE 184 Query: 241 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 300 L + + Y Y+ D+WSFG L ++ + SN K +++G + + +L+ Sbjct: 185 CLKECKFY-YASDVWSFGVTLYELL------TYCDSNQSPHTKFTELIGHTQGQMTVLRL 237 Query: 301 EITLPR 306 L R Sbjct: 238 TELLER 243 >4YHJ-A nrPDB Length = 584 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 32/107 (29%), Positives = 50/107 (46%), Gaps = 2/107 (1%) Query: 165 PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVN 224 P + FY EL L+ I++RD+KP N+++D + +R+ D GLA Sbjct: 282 PGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRG-HIRISDLGLATEIPEG 340 Query: 225 MEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 RV + + PE +V+ Y +S D W G ++ MI PF Sbjct: 341 QRVRGRVGTVGYMAPE-VVNNEKYTFSPDWWGLGCLIYEMIQGHSPF 386 >3OMV-A nrPDB Length = 307 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 43/169 (25%), Positives = 85/169 (50%), Gaps = 22/169 (13%) Query: 130 HANIIHLFD-IIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELL-------K 181 H NI+ + KD + A+V ++ + LY L E +F MF+L+ + Sbjct: 91 HVNILLFMGYMTKDNL----AIVTQWCEGSS---LYKHLHVQETKFQMFQLIDIARQTAQ 143 Query: 182 ALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEF---YHVNMEYNVRVASRFFKG 238 +DY H+ I+HRD+K +N+ + H+ +++ D+GLA + + + S + Sbjct: 144 GMDYLHAKNIIHRDMKSNNIFL-HEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMA 202 Query: 239 PEL--LVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIV 285 PE+ + D + + D++S+G +L ++ P+ H +N DQ++ +V Sbjct: 203 PEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSH-INNRDQIIFMV 250 >3Q53-A nrPDB Length = 306 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 32/125 (25%), Positives = 64/125 (51%), Gaps = 5/125 (4%) Query: 171 EIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWG-LAEFYHVNMEYNV 229 +I E L+AL++ HS ++HRD+K N+++ + ++L D+G A+ + + Sbjct: 118 QIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGM-DGSVKLTDFGFCAQITPEQSKRST 176 Query: 230 RVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLG 289 V + ++ PE +V + Y +D+WS G M MI P+ + N + + ++ G Sbjct: 177 MVGTPYWMAPE-VVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLN--ENPLRALYLIATNG 233 Query: 290 TSDFE 294 T + + Sbjct: 234 TPELQ 238 >6CTH-A nrPDB Length = 309 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 64/252 (25%), Positives = 104/252 (41%), Gaps = 60/252 (23%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKR---EIKILTDLSNEK 93 T ++ ENK+G G + V++G DS I +K + K+ IK E+KI++ L Sbjct: 14 TSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISRLR--- 70 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 H N++ L + LV+E Sbjct: 71 ------------------------------------HKNLVKLIGWCHE--RGELMLVYE 92 Query: 154 YVDN--VDFRILYPK-LTDLEIRFYMF-ELLKALDYCHSMG---IMHRDVKPHNVMIDHK 206 ++ N +D I K L E+R+ + +L AL Y H G ++HRD+K N+M+D Sbjct: 93 FMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEEGDHCVLHRDIKTSNIMLDSS 152 Query: 207 -NKKLRLIDWGLAEF--YHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLAS 263 N KL D+GLA + ++ + + + PE L + S D++SFG + Sbjct: 153 FNAKLG--DFGLARLVDHAKGLKKTLLAGTVGYMAPECLSSGKASKES-DVYSFGVVALE 209 Query: 264 MIFKR---EPFF 272 + R EP F Sbjct: 210 IASGRRSIEPKF 221 >3A4O-X nrPDB Length = 286 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 58/284 (20%), Positives = 119/284 (41%), Gaps = 53/284 (18%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--VKKKKIKREIKILTDLS 90 W + ++ ++G G++ EV+ G ++ K+ +K LKP + + E ++ L Sbjct: 8 WEIPRESIKLVKRLGAGQFGEVWMGY-YNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQ 66 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 ++K+ Y +E+ + I Y+ L D +K Sbjct: 67 HDKL--------VRLYAVVTREEPIYIITEYMAKG---------SLLDFLKS-------- 101 Query: 151 VFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 + ++L PKL D + ++ + + Y +HRD++ NV++ ++ Sbjct: 102 ------DEGGKVLLPKLID-----FSAQIAEGMAYIERKNYIHRDLRAANVLV-SESLMC 149 Query: 211 RLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 ++ D+GLA N EY R ++F + PE +++ + D+WSFG +L ++ Sbjct: 150 KIADFGLARVIEDN-EYTAREGAKFPIKWTAPEA-INFGCFTIKSDVWSFGILLYEIVTY 207 Query: 268 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDM 311 + + G +N D + T+ + Y + P E YD+ Sbjct: 208 GKIPYPGRTNADVM--------TALSQGYRMPRVENCPDELYDI 243 >4B6L-A nrPDB Length = 281 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 37/140 (26%), Positives = 70/140 (50%), Gaps = 11/140 (7%) Query: 167 LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGL-AEFYHVNM 225 L + E+R+Y+ ++L L Y H GI+HRD+K N I +N +L++ D+GL A Sbjct: 106 LLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFIT-ENMELKVGDFGLAARLEPPEQ 164 Query: 226 EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIV 285 + + PE+L+ + + D+WS G ++ +++ PF T++ + + + Sbjct: 165 RKKTICGTPNYVAPEVLLR-QGHGPEADVWSLGCVMYTLLCGSPPF--ETADLKETYRCI 221 Query: 286 KVLGTSDFEKYLLKYEITLP 305 K + Y L ++LP Sbjct: 222 KQV------HYTLPASLSLP 235 >4CSV-A nrPDB Length = 275 Score = 54.3 bits (129), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 56/284 (19%), Positives = 116/284 (40%), Gaps = 52/284 (18%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK--PVKKKKIKREIKILTDLS 90 W + +E K+G G++ EV++G + +++ +K LK + ++ +E +I+ L Sbjct: 6 WEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQIMKKLK 65 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 + P Y KE + I Y+ H + L D ++D T Sbjct: 66 H--------PNLVQLYGVCTKEPPIYIITEYM------SHGS---LLDYLRDCEGHT--- 105 Query: 151 VFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 + L D+ ++ + Y S +HRD+ N ++ +N + Sbjct: 106 -----------VNAQALLDMAA-----QVASGMAYLESQNFIHRDLAARNCLVG-ENNVV 148 Query: 211 RLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 ++ D+GLA + + EY R ++F + PE + Y + D+W+FG +L + Sbjct: 149 KVADFGLARLINED-EYTARAGAKFPIKWTAPEA-ISYNRFSIKSDVWAFGILLWEIFTY 206 Query: 268 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDM 311 + + G S ++ + ++ + Y + P E Y++ Sbjct: 207 GQVPYPGMSGSEVIEQVER--------GYRMPRPQGCPEEIYEL 242 >5D7A-A nrPDB Length = 308 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 55/247 (22%), Positives = 104/247 (42%), Gaps = 53/247 (21%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPV--KKKKIKREIKILTDLSNEKVPPT 97 +E+ VG G Y +V++G + + IK++ ++++IK+EI +L S+ + T Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIAT 78 Query: 98 --------TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 P DQ + V++F G ++ D+IK+ T Sbjct: 79 YYGAFIKKNPPGMDDQLWL-----VMEFC----------GAGSVT---DLIKNTKGNT-- 118 Query: 150 LVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 L + I + E+L+ L + H ++HRD+K NV++ +N + Sbjct: 119 -----------------LKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLT-ENAE 160 Query: 210 LRLIDWGL-AEFYHVNMEYNVRVASRFFKGPELLV----DYRMYDYSLDLWSFGTMLASM 264 ++L+D+G+ A+ N + + ++ PE++ YD+ DLWS G M Sbjct: 161 VKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEM 220 Query: 265 IFKREPF 271 P Sbjct: 221 AEGAPPL 227 >2J0K-A nrPDB Length = 656 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 57/263 (21%), Positives = 103/263 (39%), Gaps = 52/263 (19%) Query: 36 NTKDYEIENK-------VGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTD 88 +T+DYEI+ + +G G++ +V QG+ + + P IK +D Sbjct: 381 STRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPE--------NPAMAVAIKTCKNCTSD 432 Query: 89 LSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTP 148 EK L ++ FD PH I+ L +I ++ P Sbjct: 433 SVREKFLQEALTMRQ-------------------FDHPH-----IVKLIGVI----TENP 464 Query: 149 A-LVFEYVDNVDFRILYP----KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI 203 ++ E + R L + Y ++L AL Y S +HRD+ NV++ Sbjct: 465 VWIIMELCTLGELRSFLQVRKFSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLV 524 Query: 204 DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFK--GPELLVDYRMYDYSLDLWSFGTML 261 + ++L D+GL+ + + Y K PE +++R + + D+W FG + Sbjct: 525 SATD-CVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPE-SINFRRFTSASDVWMFGVCM 582 Query: 262 ASMIFKREPFFHGTSNTDQLVKI 284 ++ F G N D + +I Sbjct: 583 WEILMHGVKPFQGVKNNDVIGRI 605 >6DBN-A nrPDB Length = 316 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 49/210 (23%), Positives = 96/210 (45%), Gaps = 31/210 (14%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK---LTDLEIRF-YMFELLKALDY 185 H NI+ I + L+ E++ + + PK +L+ + Y ++ K +DY Sbjct: 96 HENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDY 155 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEY----NVRVASRFFKGPEL 241 S +HRD+ NV+++ ++ ++++ D+GL + + EY + R + F+ PE Sbjct: 156 LGSRQYVHRDLAARNVLVESEH-QVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPEC 214 Query: 242 LVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYE 301 L+ + Y S D+WSFG L ++ + S++ + +K++G + + + + Sbjct: 215 LMQSKFYIAS-DVWSFGVTLHELL------TYCDSDSSPMALFLKMIGPTHGQMTVTRLV 267 Query: 302 ITL------------PREFYDMDQYIRKPW 319 TL P E Y Q +RK W Sbjct: 268 NTLKEGKRLPCPPNCPDEVY---QLMRKCW 294 >3COM-A nrPDB Length = 314 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 34/127 (26%), Positives = 61/127 (48%), Gaps = 7/127 (5%) Query: 150 LVFEYVDNVD----FRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 +V EY R+ LT+ EI + LK L+Y H M +HRD+K N++++ Sbjct: 101 IVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNT 160 Query: 206 KNKKLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASM 264 + +L D+G+A + + N + + F+ PE++ + Y+ D+WS G M Sbjct: 161 EGHA-KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIG-YNCVADIWSLGITAIEM 218 Query: 265 IFKREPF 271 + P+ Sbjct: 219 AEGKPPY 225 >3ALO-A nrPDB Length = 327 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 32/111 (28%), Positives = 59/111 (53%), Gaps = 5/111 (4%) Query: 180 LKALDYC-HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKG 238 +KAL++ ++ I+HRD+KP N+++D ++ ++L D+G++ ++ R + Sbjct: 135 VKALNHLKENLKIIHRDIKPSNILLD-RSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMA 193 Query: 239 PELL---VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVK 286 PE + + YD D+WS G L + R P+ S DQL ++VK Sbjct: 194 PERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK 244 >4TNB-A nrPDB Length = 590 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 33/107 (30%), Positives = 51/107 (47%), Gaps = 2/107 (1%) Query: 165 PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVN 224 P + FY E+L L+ H ++RD+KP N+++D +R+ D GLA Sbjct: 281 PGFEEERALFYAAEILCGLEDLHHENTVYRDLKPENILLDDYG-HIRISDLGLAVKIPEG 339 Query: 225 MEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 RV + + PE+L + R Y S D W G ++ MI + PF Sbjct: 340 DLIRGRVGTVGYMAPEVLNNQR-YGLSPDYWGLGCLIYEMIEGQSPF 385 >2VD5-A nrPDB Length = 412 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 41/148 (27%), Positives = 64/148 (43%), Gaps = 14/148 (9%) Query: 150 LVFEYVDNVDFRILYPKLTDL----EIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 LV EY D L K + RFY+ E++ A+D H +G +HRD+KP N+++D Sbjct: 138 LVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLD- 196 Query: 206 KNKKLRLIDWGLAEFYHVNMEYN--VRVASRFFKGPELLVDYRMYDY------SLDLWSF 257 + +RL D+G + V V + + PE+L D W+ Sbjct: 197 RCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWAL 256 Query: 258 GTMLASMIFKREPFFHGTSNTDQLVKIV 285 G M + + PF+ S + KIV Sbjct: 257 GVFAYEMFYGQTPFY-ADSTAETYGKIV 283 >1U5R-A nrPDB Length = 348 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 39/132 (29%), Positives = 63/132 (47%), Gaps = 9/132 (6%) Query: 147 TPALVFEYV--DNVDFRILYPK-LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI 203 T LV EY D ++ K L ++EI L+ L Y HS ++HRDVK N+++ Sbjct: 128 TAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILL 187 Query: 204 DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPE--LLVDYRMYDYSLDLWSFGTML 261 ++L D+G A + N V + ++ PE L +D YD +D+WS G Sbjct: 188 SEPG-LVKLGDFGSAS---IMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITC 243 Query: 262 ASMIFKREPFFH 273 + ++ P F+ Sbjct: 244 IELAERKPPLFN 255 >6BXI-A nrPDB Length = 333 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 43/166 (25%), Positives = 72/166 (43%), Gaps = 43/166 (25%) Query: 150 LVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK 206 L+ E++ D L K LT+ E +FY+ E + A+D H +G +HRD+KP N+++D K Sbjct: 83 LIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSK 142 Query: 207 NKKLRLIDWGLA---------EFYHVNMEYNV---------------------------- 229 ++L D+GL EFY N+ +++ Sbjct: 143 G-HVKLSDFGLCTGLKKAHRTEFYR-NLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFS 200 Query: 230 RVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGT 275 V + + PE+ + Y+ D WS G ++ M+ PF T Sbjct: 201 TVGTPDYIAPEVFMQTG-YNKLCDWWSLGVIMYEMLIGYPPFCSET 245 >2GCD-A nrPDB Length = 309 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 39/132 (29%), Positives = 63/132 (47%), Gaps = 9/132 (6%) Query: 147 TPALVFEYV--DNVDFRILYPK-LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI 203 T LV EY D ++ K L ++EI L+ L Y HS ++HRDVK N+++ Sbjct: 89 TAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILL 148 Query: 204 DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPE--LLVDYRMYDYSLDLWSFGTML 261 ++L D+G A + N V + ++ PE L +D YD +D+WS G Sbjct: 149 SEPG-LVKLGDFGSAS---IMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITC 204 Query: 262 ASMIFKREPFFH 273 + ++ P F+ Sbjct: 205 IELAERKPPLFN 216 >4E93-A nrPDB Length = 377 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 59/244 (24%), Positives = 94/244 (38%), Gaps = 62/244 (25%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQG-VKLDS---KVKIVIKMLKPVKKKKIKREIKILTD 88 W N +D + ++GRG + EVF G ++ D+ VK + L P K K +E +IL Sbjct: 109 WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQ 168 Query: 89 LSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII--KDPISK 146 S H NI+ L + K PI Sbjct: 169 YS---------------------------------------HPNIVRLIGVCTQKQPIY- 188 Query: 147 TPALVFEYVDNVDF----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM 202 +V E V DF R +L + + + ++Y S +HRD+ N + Sbjct: 189 ---IVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCL 245 Query: 203 IDHKNKKLRLIDWGLAE-----FYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSF 257 + KN L++ D+G++ Y + +R + PE L +Y Y D+WSF Sbjct: 246 VTEKN-VLKISDFGMSREEADGVYAASG--GLRQVPVKWTAPEAL-NYGRYSSESDVWSF 301 Query: 258 GTML 261 G +L Sbjct: 302 GILL 305 >4PL5-B nrPDB Length = 435 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 64/259 (24%), Positives = 107/259 (41%), Gaps = 57/259 (22%) Query: 130 HANIIHLFDIIKD------PISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKAL 183 H N+I F KD I A + EYV+ DF L LE + + L Sbjct: 80 HPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHL-----GLEPITLLHQTTSGL 134 Query: 184 DYCHSMGIMHRDVKPHNVMID----HKNKKLRLIDWGLAEFYHVNM-EYNVRVASRFFKG 238 + HS+ I+HRD+KPHN+++ H K + D+GL + V ++ R +G Sbjct: 135 AHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEG 194 Query: 239 ---PELLVDYRMYD--YSLDLWSFGTMLASMIFKR-EPFFHGTSNTDQLVKIVKVLGTSD 292 PE+L + + Y++D++S G + +I + PF G S Q ++ Sbjct: 195 WIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF--GKSLQRQANILLGACNLDC 252 Query: 293 FEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERL 352 F K+E + RE LI+ ++ D Q+R Sbjct: 253 FHSD--KHEDVIARE-------------------------------LIEKMIAMDPQQRP 279 Query: 353 TAKEAMGHPWFAPIREQIE 371 +AK + HP+F + +Q++ Sbjct: 280 SAKHVLKHPFFWSLEKQLQ 298 >2UV2-A nrPDB Length = 325 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 41/137 (29%), Positives = 69/137 (50%), Gaps = 8/137 (5%) Query: 155 VDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLID 214 VD V + P LT+ +I+ + L AL+Y H I+HRD+K N++ + ++L D Sbjct: 121 VDAVMLELERP-LTESQIQVVCKQTLDALNYLHDNKIIHRDLKAGNILF-TLDGDIKLAD 178 Query: 215 WGL-AEFYHVNMEYNVRVASRFFKGPELLVDY----RMYDYSLDLWSFGTMLASMIFKRE 269 +G+ A+ + + + ++ PE+++ R YDY D+WS G L M + E Sbjct: 179 FGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRPYDYKADVWSLGITLIEMA-EIE 237 Query: 270 PFFHGTSNTDQLVKIVK 286 P H + L+KI K Sbjct: 238 PPHHELNPMRVLLKIAK 254 >2Y6O-A nrPDB Length = 291 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 74/326 (22%), Positives = 132/326 (40%), Gaps = 61/326 (18%) Query: 41 EIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLP 100 +IE +G G++ EV G LK K++I IK L Sbjct: 17 KIEKVIGVGEFGEVCSG------------RLKVPGKREICVAIKTL-------------- 50 Query: 101 FQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDF 160 K Y Q+ D L I Q H NIIHL ++ K ++ EY++N Sbjct: 51 --KAGYTDKQRRDFLS--EASIMGQFD--HPNIIHLEGVVTK--CKPVMIITEYMENGSL 102 Query: 161 RILYPK----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWG 216 K T +++ + + + Y M +HRD+ N++++ N ++ D+G Sbjct: 103 DAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNS-NLVCKVSDFG 161 Query: 217 LAEFYHVNME--YNVRVASRFFK--GPELLVDYRMYDYSLDLWSFG-TMLASMIFKREPF 271 ++ + E Y R + PE + YR + + D+WS+G M M + P+ Sbjct: 162 MSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA-YRKFTSASDVWSYGIVMWEVMSYGERPY 220 Query: 272 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLS 331 + SN D ++K ++ E Y L + P + Q + W + +D K Sbjct: 221 WD-MSNQD-VIKAIE-------EGYRLPPPMDCPIALH---QLMLDCWQKERSDRPKF-- 266 Query: 332 GNDEIIDLIDNLLRYDHQERLTAKEA 357 +I++++D L+R + + T E+ Sbjct: 267 --GQIVNMLDKLIRNPNSLKRTGSES 290 >4UY9-A nrPDB Length = 323 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 42/155 (27%), Positives = 75/155 (48%), Gaps = 18/155 (11%) Query: 130 HANIIHLFDI-IKDPISKTPALVFEYVDNVDF-RILYPKLTDLEIRF-YMFELLKALDYC 186 H NII L + +K+P LV E+ R+L K +I + ++ + ++Y Sbjct: 67 HPNIIALRGVCLKEP---NLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYL 123 Query: 187 HS---MGIMHRDVKPHNVMI-------DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFF 236 H + I+HRD+K N++I D NK L++ D+GLA +H + + + + Sbjct: 124 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSA-AGTYAW 182 Query: 237 KGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 PE+ + M+ D+WS+G +L ++ PF Sbjct: 183 MAPEV-IRASMFSKGSDVWSYGVLLWELLTGEVPF 216 >3PFQ-A nrPDB Length = 674 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 36/128 (28%), Positives = 64/128 (50%), Gaps = 10/128 (7%) Query: 150 LVFEYVDNVDFRILY-----PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID 204 V EYV+ D ++Y + + FY E+ L + S GI++RD+K NVM+D Sbjct: 419 FVMEYVNGGD--LMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD 476 Query: 205 HKNKKLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLAS 263 + +++ D+G+ E + + + PE++ Y+ Y S+D W+FG +L Sbjct: 477 SEG-HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA-YQPYGKSVDWWAFGVLLYE 534 Query: 264 MIFKREPF 271 M+ + PF Sbjct: 535 MLAGQAPF 542 >3DTC-A nrPDB Length = 271 Score = 52.4 bits (124), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 43/155 (27%), Positives = 75/155 (48%), Gaps = 18/155 (11%) Query: 130 HANIIHLFDI-IKDPISKTPALVFEYVDNVDF-RILYPKLTDLEIRF-YMFELLKALDYC 186 H NII L + +K+P LV E+ R+L K +I + ++ + ++Y Sbjct: 65 HPNIIALRGVCLKEP---NLCLVMEFARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYL 121 Query: 187 HS---MGIMHRDVKPHNVMI-------DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFF 236 H + I+HRD+K N++I D NK L++ D+GLA +H + + A + Sbjct: 122 HDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYAWM 181 Query: 237 KGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 PE+ + M+ D+WS+G +L ++ PF Sbjct: 182 -APEV-IRASMFSKGSDVWSYGVLLWELLTGEVPF 214 >5J5T-A nrPDB Length = 370 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 31/109 (28%), Positives = 55/109 (50%), Gaps = 4/109 (3%) Query: 167 LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGL-AEFYHVNM 225 L++L+I + E L+ L Y HS G MHRD+K N+++ N ++L D+G+ A+ Sbjct: 98 LSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLT-DNGHVKLADFGVSAQITATIA 156 Query: 226 EYNVRVASRFFKGPELLVDYRMYDYS--LDLWSFGTMLASMIFKREPFF 272 + + + ++ PE+ R Y+ DLW+ G + + P F Sbjct: 157 KRKAFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMF 205 >2V7O-A nrPDB Length = 336 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 74/339 (21%), Positives = 137/339 (40%), Gaps = 87/339 (25%) Query: 37 TKDYEIENKVGRGKYSEVFQGVK----LDSKVKIV-IKMLKPVKKKKIKREIKILTDLSN 91 T DY++ ++G+G +S V + VK + KI+ K L +K++RE +I L Sbjct: 30 TDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLK- 88 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H NI+ L D I + LV Sbjct: 89 --------------------------------------HPNIVRLHDSISE--EGFHYLV 108 Query: 152 FEYVDNVD-FRILYPK--LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK 208 F+ V + F + + ++ + + ++L+++++ H I+HRD+KP N+++ K K Sbjct: 109 FDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCK 168 Query: 209 --KLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 ++L D+GLA E + + + PE+L Y +D+W+ G +L ++ Sbjct: 169 GAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRK-DPYGKPVDIWACGVILYILL 227 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 PF+ + +L + +K G DF P +D Sbjct: 228 VGYPPFW--DEDQHKLYQQIKA-GAYDF-----------PSPEWD--------------- 258 Query: 326 GNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + E +LI+ +L + +R+TA +A+ HPW Sbjct: 259 -----TVTPEAKNLINQMLTINPAKRITADQALKHPWVC 292 >6HV0-A nrPDB Length = 416 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 63/260 (24%), Positives = 107/260 (41%), Gaps = 59/260 (22%) Query: 130 HANIIHLFDIIKD------PISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKAL 183 H N+I F KD I A + EYV+ DF L LE + + L Sbjct: 61 HPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHL-----GLEPITLLQQTTSGL 115 Query: 184 DYCHSMGIMHRDVKPHNVMID----HKNKKLRLIDWGLAEFYHVNM-EYNVRVASRFFKG 238 + HS+ I+HRD+KPHN++I H K + D+GL + V ++ R +G Sbjct: 116 AHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEG 175 Query: 239 ---PELLVDYRMYD--YSLDLWSFGTMLASMIFK-REPFFHGTSNTDQLVKIVKVLGTSD 292 PE+L + + Y++D++S G + +I + PF + +LG Sbjct: 176 WIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANI-----LLGACS 230 Query: 293 FEK-YLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQER 351 + + K+E + RE LI+ ++ D Q+R Sbjct: 231 LDCLHPEKHEDVIARE-------------------------------LIEKMIAMDPQKR 259 Query: 352 LTAKEAMGHPWFAPIREQIE 371 +AK + HP+F + +Q++ Sbjct: 260 PSAKHVLKHPFFWSLEKQLQ 279 >4PWN-A nrPDB Length = 274 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 62/341 (18%), Positives = 133/341 (39%), Gaps = 78/341 (22%) Query: 30 VIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDL 89 + S + + + + ++GRG + V++G+ ++ V++ L+ K K +R Sbjct: 2 AVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSER-------- 53 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPIS--KT 147 Q + + E +LK ++ H NI+ +D + + K Sbjct: 54 ---------------QRFKEEAE-MLKGLQ----------HPNIVRFYDSWESTVKGKKC 87 Query: 148 PALVFEYVDNVDFRILYPKLTDLEI---RFYMFELLKALDYCHSMG--IMHRDVKPHNVM 202 LV E + + + + ++I R + ++LK L + H+ I+HRD+K N+ Sbjct: 88 IVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNIF 147 Query: 203 IDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLA 262 I +++ D GLA + + F PE+ + YD S+D+++FG + Sbjct: 148 ITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMYEE--KYDESVDVYAFGMCML 205 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 M P+ + ++ + + F+K + +P Sbjct: 206 EMATSEYPYSECQNAAQIYRRVTSGVKPASFDK------VAIP----------------- 242 Query: 323 INDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 E+ ++I+ +R + ER + K+ + H +F Sbjct: 243 ------------EVKEIIEGCIRQNKDERYSIKDLLNHAFF 271 >2I0E-A nrPDB Length = 353 Score = 51.6 bits (122), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 36/128 (28%), Positives = 64/128 (50%), Gaps = 10/128 (7%) Query: 150 LVFEYVDNVDFRILY-----PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID 204 V EYV+ D ++Y + + FY E+ L + S GI++RD+K NVM+D Sbjct: 98 FVMEYVNGGD--LMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLD 155 Query: 205 HKNKKLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLAS 263 + +++ D+G+ E + + + PE++ Y+ Y S+D W+FG +L Sbjct: 156 SEG-HIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA-YQPYGKSVDWWAFGVLLYE 213 Query: 264 MIFKREPF 271 M+ + PF Sbjct: 214 MLAGQAPF 221 >4LG4-A nrPDB Length = 299 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 53/235 (22%), Positives = 100/235 (42%), Gaps = 43/235 (18%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK--KKIKREIKILTDLSNEKVPPT 97 +++ K+G G Y VF+ + +S + IK + PV+ ++I +EI I+ + Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV-PVESDLQEIIKEISIMQQCDS------ 65 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 P+ Y + K L + Y G ++ DII Sbjct: 66 --PYVVKYYGSYFKNTDLWIVMEYC------GAGSV---SDII----------------- 97 Query: 158 VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGL 217 R+ L + EI + LK L+Y H M +HR++K N++++ + +L D+G+ Sbjct: 98 ---RLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRNIKAGNILLNTEGHA-KLADFGV 153 Query: 218 A-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 A + + N + + F+ PE++ + Y+ D+WS G M + P+ Sbjct: 154 AGQLTDTMAKRNTVIGTPFWMAPEVIQEIG-YNCVADIWSLGITSIEMAEGKPPY 207 >2OU7-A nrPDB Length = 335 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 27/106 (25%), Positives = 61/106 (57%), Gaps = 3/106 (2%) Query: 167 LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME 226 LT+ E R+Y+ +++ Y H ++HRD+K N+ ++ ++ ++++ D+GLA + E Sbjct: 138 LTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEVKIGDFGLATKVEYDGE 196 Query: 227 Y-NVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 V + + PE+L + + + +D+WS G ++ +++ + PF Sbjct: 197 RKKVLCGTPNYIAPEVL-SKKGHSFEVDVWSIGCIMYTLLVGKPPF 241 >6AO5-A nrPDB Length = 362 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 53/235 (22%), Positives = 100/235 (42%), Gaps = 43/235 (18%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK--KKIKREIKILTDLSNEKVPPT 97 +++ K+G G Y VF+ + +S + IK + PV+ ++I +EI I+ + Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV-PVESDLQEIIKEISIMQQCDS------ 64 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 P+ Y + K L + Y G ++ DII Sbjct: 65 --PYVVKYYGSYFKNTDLWIVMEYC------GAGSV---SDII----------------- 96 Query: 158 VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGL 217 R+ L + EI + LK L+Y H M +HR++K N++++ + +L D+G+ Sbjct: 97 ---RLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRNIKAGNILLNTEGHA-KLADFGV 152 Query: 218 A-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 A + + N + + F+ PE++ + Y+ D+WS G M + P+ Sbjct: 153 AGQLTDTMAKRNTVIGTPFWMAPEVIQEIG-YNCVADIWSLGITSIEMAEGKPPY 206 >4U41-A nrPDB Length = 332 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 57/247 (23%), Positives = 103/247 (41%), Gaps = 53/247 (21%) Query: 40 YEIENKVGRGKYSEVFQG--VKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 +E+ VG G Y +V++G VK I + + ++++IK EI +L S+ + T Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIAT 85 Query: 98 --------TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 + P DQ + V++F G +I D++K+ T Sbjct: 86 YYGAFIKKSPPGHDDQLWL-----VMEFC----------GAGSIT---DLVKNTKGNT-- 125 Query: 150 LVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 L + I + E+L+ L + H ++HRD+K NV++ +N + Sbjct: 126 -----------------LKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLT-ENAE 167 Query: 210 LRLIDWGL-AEFYHVNMEYNVRVASRFFKGPELLV----DYRMYDYSLDLWSFGTMLASM 264 ++L+D+G+ A+ N + + ++ PE++ YDY DLWS G M Sbjct: 168 VKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEM 227 Query: 265 IFKREPF 271 P Sbjct: 228 AEGAPPL 234 >4J52-A nrPDB Length = 293 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 28/110 (25%), Positives = 63/110 (57%), Gaps = 11/110 (10%) Query: 167 LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME 226 LT+ E R+Y+ +++ Y H ++HRD+K N+ ++ ++ ++++ D+GLA +E Sbjct: 111 LTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEVKIGDFGLA----TKVE 165 Query: 227 YN-----VRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 Y+ V + + PE+L + + + +D+WS G ++ +++ + PF Sbjct: 166 YDGERKKVLCGTPNYIAPEVL-SKKGHSFEVDVWSIGCIMYTLLVGKPPF 214 >3CJF-A nrPDB Length = 309 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 32/108 (29%), Positives = 59/108 (54%), Gaps = 6/108 (5%) Query: 158 VDFRILYPKLTDLE-IRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWG 216 V ++ LY LE + Y F++ K +++ S +HRD+ N+++ KN +++ D+G Sbjct: 131 VPYKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKN-VVKICDFG 189 Query: 217 LAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTML 261 LA + + +Y + +R + PE + D R+Y D+WSFG +L Sbjct: 190 LARDIYKDPDYVRKGDARLPLKWMAPETIFD-RVYTIQSDVWSFGVLL 236 >6GQK-A nrPDB Length = 328 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 58/281 (20%), Positives = 116/281 (41%), Gaps = 48/281 (17%) Query: 46 VGRGKYSEVFQG-----VKLDSKVKIVIKMLKP----VKKKKIKREIKILTDLSNEKVPP 96 +G G + +V + +K D+ + + +KMLKP +++ + E+K+L+ L N Sbjct: 49 LGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLGNH---- 104 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 E+++ + H G +I + D ++ E+V Sbjct: 105 ---------------ENIVNLLGACT----HGGPTLVITEYCCYGDLLNFLRRKRDEFVP 145 Query: 157 -NVDFRILYPKLTDLE-IRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLID 214 V LY LE + + +++ K + + S +HRD+ N+++ H N ++ D Sbjct: 146 YKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNIT-KICD 204 Query: 215 WGLAEFYHVNMEY----NVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 +GLA + Y N R+ ++ PE + + +Y + D+WS+G L + Sbjct: 205 FGLARDIKNDSNYVDKGNARLPVKWM-APESIFN-SVYTFESDVWSYGIFLWELFSLGSS 262 Query: 271 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDM 311 + G + K++K E + + P E YD+ Sbjct: 263 PYPGMPVDSKFYKMIK-------EGFRMSSPEYAPAEMYDI 296 >6CQF-A nrPDB Length = 297 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 28/110 (25%), Positives = 55/110 (50%), Gaps = 4/110 (3%) Query: 166 KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNM 225 L++L+I + E+L+ L Y HS +HRD+K N++I+ ++RL D+G++ + Sbjct: 109 SLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAG-EVRLADFGISAQIGATL 167 Query: 226 EYNVR-VASRFFKGPELLVDYRMYDYS--LDLWSFGTMLASMIFKREPFF 272 + + + ++ PE+ Y+ D+WS G + + P F Sbjct: 168 ARRLAFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLF 217 >4LQP-A nrPDB Length = 508 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 26/82 (31%), Positives = 46/82 (56%), Gaps = 4/82 (4%) Query: 150 LVFEYVDNVDFR---ILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK 206 L+ E++ D I + T+ RFYM E + A++ H +G +HR +KP N++ID + Sbjct: 179 LIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKLGFIHRAIKPDNILIDIR 238 Query: 207 NKKLRLIDWGLAEFYHVNMEYN 228 ++L D+GL+ +H + N Sbjct: 239 G-HIKLSDFGLSTGFHKTHDSN 259 >3KUL-B nrPDB Length = 325 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 59/272 (21%), Positives = 110/272 (40%), Gaps = 41/272 (15%) Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 P + K Y Q+ D L I Q H NII L ++ + +V EY+ Sbjct: 79 PVAIKALKAGYTERQRRDFLS--EASIMGQ--FDHPNIIRLEGVVTR--GRLAMIVTEYM 132 Query: 156 DNVDF----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 +N R + T +++ + + + Y +G +HRD+ NV++D N + Sbjct: 133 ENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVD-SNLVCK 191 Query: 212 LIDWGL---------AEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLA 262 + D+GL A + + +R + PE + +R + + D+WSFG ++ Sbjct: 192 VSDFGLSRVLEDDPDAAYTTTGGKIPIR-----WTAPEAIA-FRTFSSASDVWSFGVVMW 245 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 ++ E + +N D + +S E Y L + P + + Q + WH+ Sbjct: 246 EVLAYGERPYWNMTNRDVI--------SSVEEGYRLPAPMGCP---HALHQLMLDCWHKD 294 Query: 323 INDGNKHLSGNDEIIDLIDNLLRYDHQERLTA 354 + +I+ ++D L+R R TA Sbjct: 295 RAQRPRF----SQIVSVLDALIRSPESLRATA 322 >4K33-A nrPDB Length = 325 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 31/101 (30%), Positives = 57/101 (56%), Gaps = 9/101 (8%) Query: 166 KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNM 225 +LT ++ +++ + ++Y S +HRD+ NV++ N +++ D+GLA H N+ Sbjct: 154 QLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDN-VMKIADFGLARDVH-NL 211 Query: 226 EY-----NVRVASRFFKGPELLVDYRMYDYSLDLWSFGTML 261 +Y N R+ ++ PE L D R+Y + D+WSFG +L Sbjct: 212 DYYKETTNGRLPVKWM-APEALFD-RVYTHQSDVWSFGVLL 250 >3VHK-A nrPDB Length = 368 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 27/90 (30%), Positives = 51/90 (56%), Gaps = 5/90 (5%) Query: 175 YMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASR 234 Y F++ K +++ S +HRD+ N+++ KN +++ D+GLA + + +Y + +R Sbjct: 205 YSFQVAKGMEFLASRKCIHRDLAARNILLSEKN-VVKICDFGLARDIYKDPDYVRKGDAR 263 Query: 235 F---FKGPELLVDYRMYDYSLDLWSFGTML 261 + PE + D R+Y D+WSFG +L Sbjct: 264 LPLKWMAPETIFD-RVYTIQSDVWSFGVLL 292 >5KKR-C nrPDB Length = 395 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 27/81 (33%), Positives = 43/81 (53%), Gaps = 3/81 (3%) Query: 191 IMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDY 250 IMHRDVKP N++++ + +++L D+G++ ++ N V +R + PE L Y Sbjct: 188 IMHRDVKPSNILVNSRG-EIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTH-YSV 244 Query: 251 SLDLWSFGTMLASMIFKREPF 271 D+WS G L M R P Sbjct: 245 QSDIWSMGLSLVEMAVGRYPI 265 >3DB8-A nrPDB Length = 317 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 26/106 (24%), Positives = 61/106 (57%), Gaps = 3/106 (2%) Query: 167 LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME 226 +T+ E R++M + ++ + Y H+ ++HRD+K N+ ++ + +++ D+GLA + E Sbjct: 139 VTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLN-DDMDVKIGDFGLATKIEFDGE 197 Query: 227 YNVRV-ASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 + + + PE+L + + + +D+WS G +L +++ + PF Sbjct: 198 RKKDLCGTPNYIAPEVLCK-KGHSFEVDIWSLGCILYTLLVGKPPF 242 >3EQC-A nrPDB Length = 360 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 27/81 (33%), Positives = 43/81 (53%), Gaps = 3/81 (3%) Query: 191 IMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDY 250 IMHRDVKP N++++ + +++L D+G++ ++ N V +R + PE L Y Sbjct: 153 IMHRDVKPSNILVNSRG-EIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGTH-YSV 209 Query: 251 SLDLWSFGTMLASMIFKREPF 271 D+WS G L M R P Sbjct: 210 QSDIWSMGLSLVEMAVGRYPI 230 >2PSQ-A nrPDB Length = 370 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 33/121 (27%), Positives = 66/121 (54%), Gaps = 12/121 (9%) Query: 146 KTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 + P + + Y N R+ ++T ++ ++L + ++Y S +HRD+ NV++ Sbjct: 182 RPPGMEYSYDIN---RVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVT- 237 Query: 206 KNKKLRLIDWGLAEFYHVNMEY-----NVRVASRFFKGPELLVDYRMYDYSLDLWSFGTM 260 +N +++ D+GLA + N++Y N R+ ++ PE L D R+Y + D+WSFG + Sbjct: 238 ENNVMKIADFGLARDIN-NIDYYKKTTNGRLPVKWM-APEALFD-RVYTHQSDVWSFGVL 294 Query: 261 L 261 + Sbjct: 295 M 295 >2BUJ-A nrPDB Length = 317 Score = 48.9 bits (115), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 28/117 (23%), Positives = 60/117 (51%), Gaps = 13/117 (11%) Query: 167 LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME 226 LT+ +I + + + + L+ H+ G HRD+KP N+++ + + + L+D G +++E Sbjct: 131 LTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPV-LMDLGSMNQACIHVE 189 Query: 227 ----------YNVRVASRFFKGPEL--LVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 + + + ++ PEL + + + D D+WS G +L +M+F P+ Sbjct: 190 GSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY 246 >3DKO-A nrPDB Length = 318 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 67/318 (21%), Positives = 130/318 (40%), Gaps = 69/318 (21%) Query: 41 EIENKVGRGKYSEVFQG-VKLDSK--VKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 +IE +G G++ EV G +KL K V + IK LK +K +R+ + + Sbjct: 46 KIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQ----- 100 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 FD P N++HL ++ K +V E+++N Sbjct: 101 -------------------------FDHP-----NVVHLEGVVTR--GKPVMIVIEFMEN 128 Query: 158 VDFRILYPK----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLI 213 K T +++ + + + Y MG +HRD+ N++++ N ++ Sbjct: 129 GALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVN-SNLVCKVS 187 Query: 214 DWGLAEFYHVNMEY-----NVRVASRFFKGPELLVDYRMYDYSLDLWSFG-TMLASMIFK 267 D+GL+ + E ++ R+ PE + YR + + D+WS+G M M + Sbjct: 188 DFGLSRVIEDDPEAVYTTTGGKIPVRW-TAPEA-IQYRKFTSASDVWSYGIVMWEVMSYG 245 Query: 268 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGN 327 P++ SN D ++K ++ E Y L + P + Q + W + + Sbjct: 246 ERPYWD-MSNQD-VIKAIE-------EGYRLPAPMDCPAGLH---QLMLDCWQKERAERP 293 Query: 328 KHLSGNDEIIDLIDNLLR 345 K ++I+ ++D ++R Sbjct: 294 KF----EQIVGILDKMIR 307 >4NEU-A nrPDB Length = 333 Score = 48.5 bits (114), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 40/176 (22%), Positives = 88/176 (50%), Gaps = 24/176 (13%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDF-RILYPKL-TDLEIRF-YMFELLKALDYC 186 H+ ++ L +I + +LV EY++ + +L ++ T L ++ + E+++ + Y Sbjct: 81 HSRVVKLLGVIIE--EGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYL 138 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEF--------------YHVNMEYNVRVA 232 H G++H+D+KP N+++D+ + +++ D GLA F V+ Sbjct: 139 HGKGVIHKDLKPENILVDN-DFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGG 197 Query: 233 SRFFKGPELL--VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVK 286 + ++ PE L V+ + + S D++SF +L ++ +EP+ + QL+ +K Sbjct: 198 TLYYMAPEHLNDVNAKPTEKS-DVYSFAVVLWAIFANKEPYENAICE-QQLIMCIK 251 >3BEA-A nrPDB Length = 333 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 61/305 (20%), Positives = 124/305 (40%), Gaps = 50/305 (16%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGV-----KLDSKVKIVIKMLKPV----KKKKIKREI 83 W + + +G G + +V + K D+ +K+ +KMLK +K+ + E+ Sbjct: 41 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSEL 100 Query: 84 KILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP 143 KI++ L Q E+++ + H G +I + D Sbjct: 101 KIMSHLG-------------------QHENIVNLLGACT----HGGPVLVITEYCCYGDL 137 Query: 144 IS--KTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNV 201 ++ + + V E + F I L+ ++ + ++ + + + S +HRDV NV Sbjct: 138 LNFLRRKSRVLE--TDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNV 195 Query: 202 MIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFG 258 ++ + + ++ D+GLA + Y V+ +R + PE + D +Y D+WS+G Sbjct: 196 LLTNGHVA-KIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDC-VYTVQSDVWSYG 253 Query: 259 TMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQ--YIR 316 +L + + G + K+VK + Y + P+ Y + Q + Sbjct: 254 ILLWEIFSLGLNPYPGILVNSKFYKLVK-------DGYQMAQPAFAPKNIYSIMQACWAL 306 Query: 317 KPWHR 321 +P HR Sbjct: 307 EPTHR 311 >2HK5-A nrPDB Length = 270 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 55/254 (21%), Positives = 108/254 (42%), Gaps = 50/254 (19%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--VKKKKIKREIKILTDLS 90 W + ++E K+G G++ EV+ + K+ +K +KP + + E ++ L Sbjct: 10 WEIPRESLKLEKKLGAGQFGEVWMAT-YNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQ 68 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIK-DPISKTPA 149 ++K+ K+ Y + +F+ G L D +K D SK P Sbjct: 69 HDKLVKLHAVVTKEPIYI-----ITEFM--------AKGS-----LLDFLKSDEGSKQP- 109 Query: 150 LVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 PKL D + ++ + + + +HRD++ N+++ + Sbjct: 110 --------------LPKLID-----FSAQIAEGMAFIEQRNYIHRDLRAANILVS-ASLV 149 Query: 210 LRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMI- 265 ++ D+GLA N EY R ++F + PE +++ + D+WSFG +L ++ Sbjct: 150 CKIADFGLARVIEDN-EYTAREGAKFPIKWTAPEA-INFGSFTIKSDVWSFGILLMEIVT 207 Query: 266 FKREPFFHGTSNTD 279 + R P + G SN + Sbjct: 208 YGRIP-YPGMSNPE 220 >1S9I-A nrPDB Length = 354 Score = 48.1 bits (113), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 26/81 (32%), Positives = 43/81 (53%), Gaps = 3/81 (3%) Query: 191 IMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDY 250 IMHRDVKP N++++ + +++L D+G++ ++ N V +R + PE L Y Sbjct: 136 IMHRDVKPSNILVNSRG-EIKLCDFGVSGQL-IDSMANSFVGTRSYMAPERLQGTH-YSV 192 Query: 251 SLDLWSFGTMLASMIFKREPF 271 D+WS G L + R P Sbjct: 193 QSDIWSMGLSLVELAVGRYPI 213 >4AN9-A nrPDB Length = 301 Score = 47.8 bits (112), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 27/80 (33%), Positives = 43/80 (53%), Gaps = 3/80 (3%) Query: 191 IMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDY 250 IMHRDVKP N++++ + +++L D+G++ ++ N V +R + PE L Y Sbjct: 129 IMHRDVKPSNILVNSRG-EIKLCDFGVSGQL-IDEMANEFVGTRSYMSPERLQGTH-YSV 185 Query: 251 SLDLWSFGTMLASMIFKREP 270 D+WS G L M R P Sbjct: 186 QSDIWSMGLSLVEMAVGRYP 205 >5A46-A nrPDB Length = 386 Score = 47.8 bits (112), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 57/100 (57%), Gaps = 7/100 (7%) Query: 166 KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-EFYHVN 224 +L+ ++ +++ + ++Y S +HRD+ NV++ N +++ D+GLA + +H++ Sbjct: 158 QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN-VMKIADFGLARDIHHID 216 Query: 225 ---MEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTML 261 N R+ ++ PE L D R+Y + D+WSFG +L Sbjct: 217 YYKKTTNGRLPVKWM-APEALFD-RIYTHQSDVWSFGVLL 254 >2VWV-A nrPDB Length = 302 Score = 47.4 bits (111), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 72/335 (21%), Positives = 130/335 (38%), Gaps = 67/335 (20%) Query: 41 EIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLP 100 +IE +G G++ EV +G LK KK+ IK L Sbjct: 19 KIEEVIGAGEFGEVCRG------------RLKAPGKKESCVAIKTL-------------- 52 Query: 101 FQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF-EYVDNVD 159 K Y Q+ + L I Q H NII L ++ + + P ++ E+++N Sbjct: 53 --KGGYTERQRREFLS--EASIMGQFE--HPNIIRLEGVVTNSM---PVMILTEFMENGA 103 Query: 160 F----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDW 215 R+ + T +++ + + + Y M +HRD+ N++++ N ++ D+ Sbjct: 104 LDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVN-SNLVCKVSDF 162 Query: 216 GLAEFYHVNMEYNVRVASRFFK------GPELLVDYRMYDYSLDLWSFG-TMLASMIFKR 268 GL+ F N +S K PE + +R + + D WS+G M M F Sbjct: 163 GLSRFLEENSSDPTETSSLGGKIPIRWTAPEAIA-FRKFTSASDAWSYGIVMWEVMSFGE 221 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 P++ SN D + I + Y L P + Q + W + N + Sbjct: 222 RPYWD-MSNQDVINAIE--------QDYRLPPPPDCPTSLH---QLMLDCWQKDRNARPR 269 Query: 329 HLSGNDEIIDLIDNLLRYDHQERLTAKEAMG--HP 361 +++ +D ++R ++ A+E G HP Sbjct: 270 F----PQVVSALDKMIRNPASLKIVARENGGASHP 300 >4X3F-A nrPDB Length = 337 Score = 47.4 bits (111), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 31/133 (23%), Positives = 64/133 (48%), Gaps = 9/133 (6%) Query: 145 SKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELL----KALDYCHSMGIMHRDVKPHN 200 +T LV E V+ + + L +R + ++L +AL H+ G++HRDVKP N Sbjct: 89 GRTAYLVMELVNGEPLNSVLKRTGRLSLR-HALDMLEQTGRALQIAHAAGLVHRDVKPGN 147 Query: 201 VMIDHKNKKLRLIDWGLAEFYHVN--MEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFG 258 ++I ++++ D+G+A+ + + + + + PE + + S D++S G Sbjct: 148 ILIT-PTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDASPAS-DVYSLG 205 Query: 259 TMLASMIFKREPF 271 + + + PF Sbjct: 206 VVGYEAVSGKRPF 218 >3KRL-A nrPDB Length = 335 Score = 47.4 bits (111), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 60/308 (19%), Positives = 125/308 (40%), Gaps = 54/308 (17%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGV-----KLDSKVKIVIKMLKPV----KKKKIKREI 83 W + + +G G + +V + K D+ +K+ +KMLK +K+ + E+ Sbjct: 41 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSEL 100 Query: 84 KILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP 143 KI++ L Q E+++ + H G +I + D Sbjct: 101 KIMSHLG-------------------QHENIVNLLGACT----HGGPVLVITEYCCYGDL 137 Query: 144 IS-----KTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKP 198 ++ + P L + Y + + +L+ ++ + ++ + + + S +HRDV Sbjct: 138 LNFLRRKRPPGLEYSYNPSHNPE---EQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAA 194 Query: 199 HNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLW 255 NV++ + + ++ D+GLA + Y V+ +R + PE + D +Y D+W Sbjct: 195 RNVLLTNGHVA-KIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDC-VYTVQSDVW 252 Query: 256 SFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQ-- 313 S+G +L + + G + K+VK + Y + P+ Y + Q Sbjct: 253 SYGILLWEIFSLGLNPYPGILVNSKFYKLVK-------DGYQMAQPAFAPKNIYSIMQAC 305 Query: 314 YIRKPWHR 321 + +P HR Sbjct: 306 WALEPTHR 313 >4OW8-A nrPDB Length = 283 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 31/133 (23%), Positives = 64/133 (48%), Gaps = 9/133 (6%) Query: 145 SKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELL----KALDYCHSMGIMHRDVKPHN 200 +T LV E V+ + + L +R + ++L +AL H+ G++HRDVKP N Sbjct: 88 GRTAYLVMELVNGEPLNSVLKRTGRLSLR-HALDMLEQTGRALQIAHAAGLVHRDVKPGN 146 Query: 201 VMIDHKNKKLRLIDWGLAEFYHVN--MEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFG 258 ++I ++++ D+G+A+ + + + + + PE + + S D++S G Sbjct: 147 ILIT-PTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDASPAS-DVYSLG 204 Query: 259 TMLASMIFKREPF 271 + + + PF Sbjct: 205 VVGYEAVSGKRPF 217 >3TT0-A nrPDB Length = 382 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 57/100 (57%), Gaps = 7/100 (7%) Query: 166 KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-EFYHVN 224 +L+ ++ +++ + ++Y S +HRD+ NV++ N +++ D+GLA + +H++ Sbjct: 187 QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN-VMKIADFGLARDIHHID 245 Query: 225 ---MEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTML 261 N R+ ++ PE L D R+Y + D+WSFG +L Sbjct: 246 YYKKTTNGRLPVKWM-APEALFD-RIYTHQSDVWSFGVLL 283 >5O0Y-A nrPDB Length = 579 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 43/169 (25%), Positives = 82/169 (48%), Gaps = 17/169 (10%) Query: 130 HANIIHLFDIIK-DPISKTPALVFEYVDNVDFRILYPKL-TDLEIRFYMFELLKALDYCH 187 H I+ L+D D S L + +++DF + KL ++ E R + +++ AL Y + Sbjct: 347 HPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLN 406 Query: 188 SMG--IMHRDVKPHNVMIDHKNK--KLRLIDWGLAEF-----YHV--NMEYNVRVASRF- 235 + I+H D+KP N+++ + ++++ D+GL++ Y+ ME + A + Sbjct: 407 EIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYW 466 Query: 236 FKGPELLV---DYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQL 281 + PE V + +D+WS G + ++ R+PF H S D L Sbjct: 467 YLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDIL 515 >5MJB-A nrPDB Length = 305 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 58/255 (22%), Positives = 105/255 (41%), Gaps = 48/255 (18%) Query: 41 EIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLP 100 +IE +G G++ EV++G LK K++I IK L Sbjct: 29 KIEEVIGAGEFGEVYKG------------RLKLPGKREIYVAIKTL-------------- 62 Query: 101 FQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDF 160 K Y Q+ D L I Q H NII L ++ S+ ++ E+++N Sbjct: 63 --KAGYSEKQRRDFLS--EASIMGQFD--HRNIIRLEGVVTK--SRPVMIITEFMENCAL 114 Query: 161 ----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWG 216 R + T +++ + + + Y M +HRD+ N+++ + N ++ D+G Sbjct: 115 DSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILV-NSNLVCKVSDFG 173 Query: 217 LAEFYHVNME---YNVRVASRF---FKGPELLVDYRMYDYSLDLWSFG-TMLASMIFKRE 269 L+ + + Y + + + PE + YR + + D+WS+G M M F Sbjct: 174 LSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIA-YRKFTSASDVWSYGIVMWEVMSFGER 232 Query: 270 PFFHGTSNTDQLVKI 284 P++ SN D + I Sbjct: 233 PYWD-MSNQDVINAI 246 >6E4F-A nrPDB Length = 290 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 51/235 (21%), Positives = 103/235 (43%), Gaps = 46/235 (19%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK--PVKKKKIKREIKILTDL 89 W + KD ++G G++ V G K + + IKM+K + + + E K++ +L Sbjct: 25 SWEIDPKDLTFLKELGTGQFGVVKYG-KWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNL 83 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 S+EK+ Y K+ + I Y+ AN Sbjct: 84 SHEKLVQL--------YGVCTKQRPIFIITEYM--------AN----------------G 111 Query: 150 LVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 + Y+ + R +L ++ ++ +A++Y S +HRD+ N +++ + Sbjct: 112 CLLNYLREMRHRFQTQQLLEM-----CKDVCEAMEYLESKQFLHRDLAARNCLVNDQG-V 165 Query: 210 LRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTML 261 +++ D+GL+ Y ++ EY V S+F + PE+L+ Y + D+W+FG ++ Sbjct: 166 VKVSDFGLSR-YVLDDEYTSSVGSKFPVRWSPPEVLM-YSKFSSKSDIWAFGVLM 218 >3GQL-A nrPDB Length = 326 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 57/100 (57%), Gaps = 7/100 (7%) Query: 166 KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-EFYHVN 224 +L+ ++ +++ + ++Y S +HRD+ NV++ N +++ D+GLA + +H++ Sbjct: 146 QLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN-VMKIADFGLARDIHHID 204 Query: 225 ---MEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTML 261 N R+ ++ PE L D R+Y + D+WSFG +L Sbjct: 205 YYKKTTNGRLPVKWM-APEALFD-RIYTHQSDVWSFGVLL 242 >6B2Q-A nrPDB Length = 317 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 31/133 (23%), Positives = 64/133 (48%), Gaps = 9/133 (6%) Query: 145 SKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELL----KALDYCHSMGIMHRDVKPHN 200 +T LV E V+ + + L +R + ++L +AL H+ G++HRDVKP N Sbjct: 109 GRTAYLVMELVNGEPLNSVLKRTGRLSLR-HALDMLEQTGRALQIAHAAGLVHRDVKPGN 167 Query: 201 VMIDHKNKKLRLIDWGLAEFYHVN--MEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFG 258 ++I ++++ D+G+A+ + + + + + PE + + S D++S G Sbjct: 168 ILIT-PTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDASPAS-DVYSLG 225 Query: 259 TMLASMIFKREPF 271 + + + PF Sbjct: 226 VVGYEAVSGKRPF 238 >3PLS-A nrPDB Length = 298 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 53/237 (22%), Positives = 102/237 (43%), Gaps = 50/237 (21%) Query: 46 VGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQ 105 +G+G + V+ G +D + +I+ IK L+ ++ Sbjct: 29 IGKGHFGVVYHGEYIDQA------------QNRIQCAIKSLSRIT--------------- 61 Query: 106 YYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILY- 164 + + V F+R + + N H N++ L I+ P P ++ Y+ + D Sbjct: 62 ----EMQQVEAFLREGLLMRGLN-HPNVLALIGIMLPP-EGLPHVLLPYMCHGDLLQFIR 115 Query: 165 -----PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA- 218 P + DL I F + ++ + ++Y +HRD+ N M+D ++ +++ D+GLA Sbjct: 116 SPQRNPTVKDL-ISFGL-QVARGMEYLAEQKFVHRDLAARNCMLD-ESFTVKVADFGLAR 172 Query: 219 -----EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 E+Y V + R+ + + E L YR S D+WSFG +L ++ + P Sbjct: 173 DILDREYYSVQQHRHARLPVK-WTALESLQTYRFTTKS-DVWSFGVLLWELLTRGAP 227 >5CEK-A nrPDB Length = 263 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 64/259 (24%), Positives = 107/259 (41%), Gaps = 54/259 (20%) Query: 118 IRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF---EYVDNVDFRILYPKLTDLEIRF 174 IRPYI P H+NI + ++I + +T A VF ++ D + +L + E Sbjct: 51 IRPYI-QLP--SHSNITGIVEVI---LGETKAYVFFEKDFGDMHSYVRSRKRLREEEAAR 104 Query: 175 YMFELLKALDYCHSMGIMHRDVKPHN-VMIDHKNKKLRLIDWGLAEFYHVNMEYNV---R 230 +++ A+ +CH I+ D+K V + +LRL L + + + E + + Sbjct: 105 LFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRL--ESLEDTHIMKGEDDALSDK 162 Query: 231 VASRFFKGPELLVDYRMYDY-SLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLG 289 + PE+L Y + D+WS G ML +++ R P FH + + KI Sbjct: 163 HGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYP-FHDSDPSALFSKI----- 216 Query: 290 TSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQ 349 + + +P +H+S LI +LLR + Sbjct: 217 --------RRGQFCIP----------------------EHISPKARC--LIRSLLRREPS 244 Query: 350 ERLTAKEAMGHPWFAPIRE 368 ERLTA E + HPWF + E Sbjct: 245 ERLTAPEILLHPWFESVLE 263 >6DC0-A nrPDB Length = 292 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 64/259 (24%), Positives = 107/259 (41%), Gaps = 54/259 (20%) Query: 118 IRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF---EYVDNVDFRILYPKLTDLEIRF 174 IRPYI P H+NI + ++I + +T A VF ++ D + +L + E Sbjct: 48 IRPYI-QLP--SHSNITGIVEVI---LGETKAYVFFEKDFGDMHSYVRSRKRLREEEAAR 101 Query: 175 YMFELLKALDYCHSMGIMHRDVKPHN-VMIDHKNKKLRLIDWGLAEFYHVNMEYNV---R 230 +++ A+ +CH I+ D+K V + +LRL L + + + E + + Sbjct: 102 LFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRL--ESLEDTHIMKGEDDALSDK 159 Query: 231 VASRFFKGPELLVDYRMYDY-SLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLG 289 + PE+L Y + D+WS G ML +++ R P FH + + KI Sbjct: 160 HGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYP-FHDSDPSALFSKI----- 213 Query: 290 TSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQ 349 + + +P +H+S LI +LLR + Sbjct: 214 --------RRGQFCIP----------------------EHISPKARC--LIRSLLRREPS 241 Query: 350 ERLTAKEAMGHPWFAPIRE 368 ERLTA E + HPWF + E Sbjct: 242 ERLTAPEILLHPWFESVLE 260 >1JPA-A nrPDB Length = 312 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 56/248 (22%), Positives = 101/248 (40%), Gaps = 49/248 (19%) Query: 41 EIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLP 100 +IE +G G++ EV G LK K++I IK L Sbjct: 36 KIEQVIGAGEFGEVCSG------------HLKLPGKREIFVAIKTL-------------- 69 Query: 101 FQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF-EYVDNVD 159 K Y Q+ D L I Q H N+IHL ++ TP ++ E+++N Sbjct: 70 --KSGYTEKQRRDFLS--EASIMGQ--FDHPNVIHLEGVVT---KSTPVMIITEFMENGS 120 Query: 160 F----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDW 215 R + T +++ + + + Y M +HRD+ N++++ N ++ D+ Sbjct: 121 LDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVN-SNLVCKVSDF 179 Query: 216 GLAEFYHVNME---YNVRVASRF---FKGPELLVDYRMYDYSLDLWSFG-TMLASMIFKR 268 GL+ F + Y + + + PE + YR + + D+WS+G M M + Sbjct: 180 GLSRFLEDDTSDPTYTSALGGKIPIRWTAPEA-IQYRKFTSASDVWSYGIVMWEVMSYGE 238 Query: 269 EPFFHGTS 276 P++ T+ Sbjct: 239 RPYWDMTN 246 >5WNL-A nrPDB Length = 342 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 35/163 (21%), Positives = 89/163 (54%), Gaps = 14/163 (8%) Query: 133 IIHLFDIIKDPISKTPALVFEYVDNVDF-RILYPKLTDLEIRFYMF-ELLKALDYCHSMG 190 I+ ++ I ++P+ LV EY++ ++L + ++RF + E +++ H M Sbjct: 81 ILPVYGICQEPV----GLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMS 136 Query: 191 --IMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF----FKGPELLVD 244 ++H ++KP N+++D + +++ D+GLA+ ++ +++ + F + PE + + Sbjct: 137 PPLLHLNLKPANILLD-AHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIRE 195 Query: 245 -YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVK 286 R++D D++SF ++ ++ +++PF + ++K+VK Sbjct: 196 KSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVK 238 >4IDT-A nrPDB Length = 356 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 31/110 (28%), Positives = 50/110 (45%), Gaps = 10/110 (9%) Query: 174 FYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVAS 233 +Y+ + L+ L+Y HS I+H DVK NV++ L D+G A + + Sbjct: 170 YYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTG 229 Query: 234 RFFKG------PELLVDYRMYDYSLDLWSFGTMLASMIFKREP---FFHG 274 + G PE+++ R D +D+WS M+ M+ P FF G Sbjct: 230 DYIPGTETHMAPEVVLG-RSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRG 278 >4XI2-A nrPDB Length = 446 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 53/244 (21%), Positives = 105/244 (43%), Gaps = 64/244 (26%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK--PVKKKKIKREIKILTDL 89 W + KD ++G G++ V G K + + IKM++ + + + E K++ +L Sbjct: 181 SWEIDPKDLTFLKELGTGQFGVVKYG-KWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNL 239 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII--KDPISKT 147 S+EK ++ L+ + + PI Sbjct: 240 SHEK---------------------------------------LVQLYGVCTKQRPI--- 257 Query: 148 PALVFEYVDNVDFRILYPKLTDLEIRFYMFELLK-------ALDYCHSMGIMHRDVKPHN 200 ++ EY+ N L L ++ RF +LL+ A++Y S +HRD+ N Sbjct: 258 -FIITEYMAN---GCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARN 313 Query: 201 VMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSF 257 +++ + +++ D+GL+ Y ++ EY V S+F + PE+L+ Y + D+W+F Sbjct: 314 CLVNDQG-VVKVSDFGLSR-YVLDDEYTSSVGSKFPVRWSPPEVLM-YSKFSSKSDIWAF 370 Query: 258 GTML 261 G ++ Sbjct: 371 GVLM 374 >2PL0-A nrPDB Length = 289 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 48/253 (18%), Positives = 103/253 (40%), Gaps = 46/253 (18%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK--PVKKKKIKREIKILTDL 89 +W + ++ ++G G++ EV+ G + K+ +K LK + E ++ L Sbjct: 17 EWEVPRETLKLVERLGAGQFGEVWMGY-YNGHTKVAVKSLKQGSMSPDAFLAEANLMKQL 75 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 ++++ + Y ++ + I Y+ NG L D +K P Sbjct: 76 QHQRL---------VRLYAVVTQEPIYIITEYM----ENG-----SLVDFLKTPSG---- 113 Query: 150 LVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 ++ KL D+ ++ + + + +HRD++ N+++ Sbjct: 114 ----------IKLTINKLLDMAA-----QIAEGMAFIEERNYIHRDLRAANILVS-DTLS 157 Query: 210 LRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 ++ D+GLA N EY R ++F + PE ++Y + D+WSFG +L ++ Sbjct: 158 CKIADFGLARLIEDN-EYTAREGAKFPIKWTAPE-AINYGTFTIKSDVWSFGILLTEIVT 215 Query: 267 KREPFFHGTSNTD 279 + G +N + Sbjct: 216 HGRIPYPGMTNPE 228 >6GVJ-A nrPDB Length = 429 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 46/205 (22%), Positives = 83/205 (40%), Gaps = 50/205 (24%) Query: 171 EIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVR 230 E + Y +L+A+ H GI+H D+KP N +I + L+LID+G+A + V+ Sbjct: 244 ERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVK 301 Query: 231 ---VASRFFKGPELLVDYR----------MYDYSLDLWSFGTMLASMIFKREPFFHGTSN 277 V + + PE + D D+WS G +L M + + PF + Sbjct: 302 DSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQ 361 Query: 278 TDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEII 337 +L I+ +EI EF D+ + ++ Sbjct: 362 ISKLHAIIDP-----------NHEI----EFPDIPE--------------------KDLQ 386 Query: 338 DLIDNLLRYDHQERLTAKEAMGHPW 362 D++ L+ D ++R++ E + HP+ Sbjct: 387 DVLKCCLKRDPKQRISIPELLAHPY 411 >4JRN-A nrPDB Length = 372 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 39/167 (23%), Positives = 71/167 (42%), Gaps = 18/167 (10%) Query: 170 LEIRFYMF-ELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYN 228 L +R Y+ + +K + + GI+H D+KP N ++ K+ +L L D+G Y +N Sbjct: 201 LVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLL-LKDGRLFLGDFGT---YRINNSVG 256 Query: 229 VRVASRFFKGPE--LLVDYRMYDYSLDLWSFGTMLASMIFKREPF----------FHGTS 276 + + ++ PE Y + D W G L + K P F Sbjct: 257 RAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTPADGIWDYLHFADCP 316 Query: 277 NTDQLVK-IVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 +T +LV+ +++ L D +K +L + F +MD ++ F Sbjct: 317 STPELVQDLIRSLLNRDPQKRMLPLQALETAAFKEMDSVVKGAAQNF 363 >5X02-A nrPDB Length = 347 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 53/269 (19%), Positives = 101/269 (37%), Gaps = 80/269 (29%) Query: 31 IDWSTNTKDYEIENKVGRGKYSEVFQGV-----KLDSKVKIVIKMLK----PVKKKKIKR 81 + W ++ E +G G + +V K +++ +KMLK +++ + Sbjct: 41 LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMS 100 Query: 82 EIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIK 141 E+K++T L + H NI++L Sbjct: 101 ELKMMTQLGS--------------------------------------HENIVNLLGACT 122 Query: 142 DPISKTPALVFEYVDNVDF----RILYPKLTDLEIRF----------------------Y 175 +S L+FEY D R K ++ EI + + Sbjct: 123 --LSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLTFEDLLCF 180 Query: 176 MFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF 235 +++ K +++ +HRD+ NV++ H K +++ D+GLA + Y VR +R Sbjct: 181 AYQVAKGMEFLEFKSCVHRDLAARNVLVTH-GKVVKICDFGLARDIMSDSNYVVRGNARL 239 Query: 236 ---FKGPELLVDYRMYDYSLDLWSFGTML 261 + PE L + +Y D+WS+G +L Sbjct: 240 PVKWMAPESLFE-GIYTIKSDVWSYGILL 267 >3HNG-A nrPDB Length = 360 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 24/90 (26%), Positives = 51/90 (56%), Gaps = 5/90 (5%) Query: 175 YMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASR 234 Y F++ + +++ S +HRD+ N+++ +N +++ D+GLA + N +Y + +R Sbjct: 204 YSFQVARGMEFLSSRKCIHRDLAARNILL-SENNVVKICDFGLARDIYKNPDYVRKGDTR 262 Query: 235 F---FKGPELLVDYRMYDYSLDLWSFGTML 261 + PE + D ++Y D+WS+G +L Sbjct: 263 LPLKWMAPESIFD-KIYSTKSDVWSYGVLL 291 >5EG3-A nrPDB Length = 334 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 27/90 (30%), Positives = 53/90 (58%), Gaps = 9/90 (10%) Query: 177 FELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEY-----NVRV 231 ++L + ++Y S +HRD+ NV++ +N +++ D+GLA + N+++ N R+ Sbjct: 164 YQLARGMEYLASQKCIHRDLAARNVLV-TENNVMKIADFGLARDIN-NIDFFKETTNGRL 221 Query: 232 ASRFFKGPELLVDYRMYDYSLDLWSFGTML 261 ++ PE L D R+Y + D+WSFG ++ Sbjct: 222 PVKWM-APEALFD-RVYTHQSDVWSFGVLM 249 >5HLW-A nrPDB Length = 299 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 54/237 (22%), Positives = 99/237 (41%), Gaps = 50/237 (21%) Query: 46 VGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQ 105 +GRG + V+ G LD+ KKI +K L +++ Sbjct: 28 IGRGHFGCVYHGTLLDND------------GKKIHCAVKSLNRITDIG------------ 63 Query: 106 YYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILY- 164 +V +F+ I + + H N++ L I +P +V Y+ + D R Sbjct: 64 -------EVSQFLTEGIIMKDFS-HPNVLSLLGICLRS-EGSPLVVLPYMKHGDLRNFIR 114 Query: 165 -----PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA- 218 P + DL I F + ++ K + Y S +HRD+ N M+D K +++ D+GLA Sbjct: 115 NETHNPTVKDL-IGFGL-QVAKGMKYLASKKFVHRDLAARNCMLDEKF-TVKVADFGLAR 171 Query: 219 -----EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 E+Y V+ + ++ ++ L + + D+WSFG +L ++ + P Sbjct: 172 DMHDKEYYSVHNKTGAKLPVKWMALESL--QTQKFTTKSDVWSFGVLLWELMTRGAP 226 >5GRN-A nrPDB Length = 356 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 52/231 (22%), Positives = 101/231 (43%), Gaps = 31/231 (13%) Query: 46 VGRGKYSEVFQGV-----KLDSKVKIVIKMLKPV----KKKKIKREIKILTDLSNEKVPP 96 +G G + +V +G + +K+ +KMLKP +K+ + E+KI+T L Sbjct: 54 LGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIV 113 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI--SKTPALVFEY 154 L K + I Y F + ++++ +D K +++ Sbjct: 114 NLLG-------ACTKSGPIYIITEYCF------YGDLVNYLHKNRDSFLSHKKKSMLDSE 160 Query: 155 VDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLID 214 V N+ LT L++ + +++ + +++ S +HRD+ NV++ + K +++ D Sbjct: 161 VKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLL-AQGKIVKICD 219 Query: 215 WGLAEFYHVNMEYNVRVASRFFK----GPELLVDYRMYDYSLDLWSFGTML 261 +GLA + Y V S F PE + D +Y D+WS+G +L Sbjct: 220 FGLARDIMHDSNY-VSKGSTFLPVKWMAPESIFD-NLYTTLSDVWSYGILL 268 >4H1J-A nrPDB Length = 293 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 28/110 (25%), Positives = 55/110 (50%), Gaps = 5/110 (4%) Query: 166 KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNM 225 L L + Y ++ KA+ Y S+ +HRD+ N+++ + ++L D+GL+ + Sbjct: 121 SLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASP-ECVKLGDFGLSRYIEDED 179 Query: 226 EYNVRVASRFFK--GPELLVDYRMYDYSLDLWSFGTMLASMI-FKREPFF 272 Y V K PE +++R + + D+W F + ++ F ++PFF Sbjct: 180 YYKASVTRLPIKWMSPE-SINFRRFTTASDVWMFAVCMWEILSFGKQPFF 228 >3LM0-A nrPDB Length = 327 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 32/145 (22%), Positives = 72/145 (49%), Gaps = 9/145 (6%) Query: 150 LVFEYVDNVD-FRILYPKLTDL----EIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID 204 L+ EY + F + P+L ++ ++ + ++L+ + Y H I+H D+KP N+++ Sbjct: 106 LILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLS 165 Query: 205 --HKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLA 262 + ++++D+G++ E + + + PE+L +Y + D+W+ G ++A Sbjct: 166 SIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEIL-NYDPITTATDMWNIG-IIA 223 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKV 287 M+ F G N + + I +V Sbjct: 224 YMLLTHTSPFVGEDNQETYLNISQV 248 >4APC-A nrPDB Length = 350 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 24/102 (23%), Positives = 53/102 (51%), Gaps = 3/102 (2%) Query: 175 YMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEY-NVRVAS 233 + ++ AL + H I+HRD+K N+ + K+ ++L D+G+A + +E + + Sbjct: 130 WFVQICLALKHVHDRKILHRDIKSQNIFLT-KDGTVQLGDFGIARVLNSTVELARACIGT 188 Query: 234 RFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGT 275 ++ PE + + + Y+ D+W+ G +L + + F G+ Sbjct: 189 PYYLSPE-ICENKPYNNKSDIWALGCVLYELCTLKHAFEAGS 229 >4XUF-A nrPDB Length = 297 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 53/269 (19%), Positives = 101/269 (37%), Gaps = 80/269 (29%) Query: 31 IDWSTNTKDYEIENKVGRGKYSEVFQGV-----KLDSKVKIVIKMLK----PVKKKKIKR 81 + W ++ E +G G + +V K +++ +KMLK +++ + Sbjct: 2 LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMS 61 Query: 82 EIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIK 141 E+K++T L + H NI++L Sbjct: 62 ELKMMTQLGS--------------------------------------HENIVNLLGACT 83 Query: 142 DPISKTPALVFEYVDNVDF----RILYPKLTDLEIRF----------------------Y 175 +S L+FEY D R K ++ EI + + Sbjct: 84 --LSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLTFEDLLCF 141 Query: 176 MFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF 235 +++ K +++ +HRD+ NV++ H K +++ D+GLA + Y VR +R Sbjct: 142 AYQVAKGMEFLEFKSCVHRDLAARNVLVTH-GKVVKICDFGLARDIMSDSNYVVRGNARL 200 Query: 236 ---FKGPELLVDYRMYDYSLDLWSFGTML 261 + PE L + +Y D+WS+G +L Sbjct: 201 PVKWMAPESLFE-GIYTIKSDVWSYGILL 228 >5VD3-A nrPDB Length = 311 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 32/116 (27%), Positives = 53/116 (45%), Gaps = 4/116 (3%) Query: 166 KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNM 225 L + ++ Y+ + L AL + HS G++H DVKP N+ + + + +L D+GL Sbjct: 153 SLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRG-RCKLGDFGLLVELGTAG 211 Query: 226 EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQL 281 V+ + PELL Y + D++S G + + E HG QL Sbjct: 212 AGEVQEGDPRYMAPELLQGS--YGTAADVFSLGLTILEVACNME-LPHGGEGWQQL 264 >4R7H-A nrPDB Length = 343 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 66/316 (20%), Positives = 125/316 (39%), Gaps = 63/316 (19%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGV-----KLDSKVKIVIKMLKPV----KKKKIKREI 83 W + + +G G + +V + K D+ +K+ +KMLK +K+ + E+ Sbjct: 45 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSEL 104 Query: 84 KILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP 143 KI++ L Q E+++ + H G +I + D Sbjct: 105 KIMSHLG-------------------QHENIVNLLGACT----HGGPVLVITEYCTYGDL 141 Query: 144 I-------------SKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMG 190 + S +P E +D D R L +L DL + ++ + + + S Sbjct: 142 LNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPL--ELRDL--LHFSSQVAQGMAFLASKN 197 Query: 191 IMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRM 247 +HRDV NV++ + + ++ D+GLA + Y V+ +R + PE + D + Sbjct: 198 CIHRDVAARNVLLTNGHVA-KIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFD-SV 255 Query: 248 YDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPRE 307 Y D+WS+G +L + + G + K+VK + Y + P+ Sbjct: 256 YTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK-------DGYQMAQPAFAPKN 308 Query: 308 FYDMDQ--YIRKPWHR 321 Y + Q + +P HR Sbjct: 309 IYSIMQACWALEPTHR 324 >4XCU-A nrPDB Length = 300 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 28/90 (31%), Positives = 51/90 (56%), Gaps = 9/90 (10%) Query: 177 FELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEY-----NVRV 231 +++ + + Y S +HRD+ NV++ N +++ D+GLA H +++Y N R+ Sbjct: 137 YQVARGMQYLESRKCIHRDLAARNVLVTEDN-VMKIADFGLARGVH-HIDYYKKTSNGRL 194 Query: 232 ASRFFKGPELLVDYRMYDYSLDLWSFGTML 261 ++ PE L D R+Y + D+WSFG +L Sbjct: 195 PVKWM-APEALFD-RVYTHQSDVWSFGILL 222 >5HVK-A nrPDB Length = 315 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 29/106 (27%), Positives = 53/106 (50%), Gaps = 19/106 (17%) Query: 178 ELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFY---------------- 221 ++ + Y HSM I+HR++ HN ++ +NK + + D+GLA Sbjct: 120 DIASGMAYLHSMNIIHRNLNSHNCLV-RENKNVVVADFGLARLMVDEKTQPEGLRSLKKP 178 Query: 222 HVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 Y V V + ++ PE +++ R YD +D++SFG +L +I + Sbjct: 179 DRKKRYTV-VGNPYWMAPE-MINGRSYDEKVDVFSFGIVLCEIIGR 222 >4Y93-A nrPDB Length = 446 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 52/244 (21%), Positives = 103/244 (42%), Gaps = 64/244 (26%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK--PVKKKKIKREIKILTDL 89 W + KD ++G G++ V G K + + IKM+K + + + E K++ +L Sbjct: 182 SWEIDPKDLTFLKELGTGQFGVVKYG-KWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNL 240 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII--KDPISKT 147 S+EK ++ L+ + + PI Sbjct: 241 SHEK---------------------------------------LVQLYGVCTKQRPI--- 258 Query: 148 PALVFEYVDNVDFRILYPKLTDLEIRFYMFELLK-------ALDYCHSMGIMHRDVKPHN 200 ++ EY+ N L L ++ RF +LL+ A++Y S +HRD+ N Sbjct: 259 -FIITEYMAN---GCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARN 314 Query: 201 VMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSF 257 +++ + +++ D+G+ Y ++ EY S+F + PE+L+ Y + D+W+F Sbjct: 315 CLVNDQG-VVKVSDFGMTR-YVLDDEYTSSTGSKFPVKWASPEVLM-YSKFSSKSDIWAF 371 Query: 258 GTML 261 G ++ Sbjct: 372 GVLM 375 >2OGV-A nrPDB Length = 317 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 63/303 (20%), Positives = 122/303 (40%), Gaps = 50/303 (16%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGV-----KLDSKVKIVIKMLKPV----KKKKIKREI 83 W + + +G G + +V + K D+ +K+ +KMLK +K+ + E+ Sbjct: 33 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSEL 92 Query: 84 KILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP 143 KI++ L Q E+++ + H G +I + D Sbjct: 93 KIMSHLG-------------------QHENIVNLLGACT----HGGPVLVITEYCCYGDL 129 Query: 144 ISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI 203 ++ +D D R L +L DL + ++ + + + S +HRDV NV++ Sbjct: 130 LNFLRRKAEADLDKEDGRPL--ELRDL--LHFSSQVAQGMAFLASKNCIHRDVAARNVLL 185 Query: 204 DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTM 260 + + ++ D+GLA + Y V+ +R + PE + D +Y D+WS+G + Sbjct: 186 TNGHVA-KIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDC-VYTVQSDVWSYGIL 243 Query: 261 LASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQ--YIRKP 318 L + + G + K+VK + Y + P+ Y + Q + +P Sbjct: 244 LWEIFSLGLNPYPGILVNSKFYKLVK-------DGYQMAQPAFAPKNIYSIMQACWALEP 296 Query: 319 WHR 321 HR Sbjct: 297 THR 299 >4HVI-A nrPDB Length = 314 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 32/127 (25%), Positives = 62/127 (48%), Gaps = 10/127 (7%) Query: 143 PISKTPALVFEYVDNVDFRILY----PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKP 198 P ++ LV EY+ + R +L + Y ++ K ++Y S +HRD+ Sbjct: 83 PGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAA 142 Query: 199 HNVMIDHKNKKLRLIDWGLAEFYHVNMEYNV----RVASRFFKGPELLVDYRMYDYSLDL 254 N++++ +++ D+GLA+ ++ +Y V + F+ PE L D ++ D+ Sbjct: 143 RNILVE-SEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSD-NIFSRQSDV 200 Query: 255 WSFGTML 261 WSFG +L Sbjct: 201 WSFGVVL 207 >3HMP-A nrPDB Length = 342 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 32/114 (28%), Positives = 52/114 (45%), Gaps = 15/114 (13%) Query: 171 EIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVR 230 E + Y +L+A+ H GI+H D+KP N +I + L+LID+G+A + V+ Sbjct: 156 ERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVK 213 Query: 231 ---VASRFFKGPELLVDYR----------MYDYSLDLWSFGTMLASMIFKREPF 271 V + + PE + D D+WS G +L M + + PF Sbjct: 214 DSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF 267 >2ZMD-A nrPDB Length = 390 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 32/114 (28%), Positives = 52/114 (45%), Gaps = 15/114 (13%) Query: 171 EIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVR 230 E + Y +L+A+ H GI+H D+KP N +I + L+LID+G+A + V+ Sbjct: 156 ERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVK 213 Query: 231 ---VASRFFKGPELLVDYR----------MYDYSLDLWSFGTMLASMIFKREPF 271 V + + PE + D D+WS G +L M + + PF Sbjct: 214 DSQVGAVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF 267 >5AP3-A nrPDB Length = 313 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 34/128 (26%), Positives = 57/128 (44%), Gaps = 15/128 (11%) Query: 171 EIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVR 230 E + Y +L+A+ H GI+H D+KP N +I + L+LID+G+A + V+ Sbjct: 128 ERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVK 185 Query: 231 ---VASRFFKGPELLVDYR----------MYDYSLDLWSFGTMLASMIFKREPFFHGTSN 277 V + + PE + D D+WS G +L M + + PF + Sbjct: 186 DSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQ 245 Query: 278 TDQLVKIV 285 +L I+ Sbjct: 246 ISKLHAII 253 >4XEY-B nrPDB Length = 408 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 47/243 (19%), Positives = 94/243 (38%), Gaps = 62/243 (25%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--------VKKKKIKREIK 84 W D +++K+G G+Y EV++GV + + +K LK +K+ + +EIK Sbjct: 120 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 179 Query: 85 ILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII-KDP 143 H N++ L + ++P Sbjct: 180 ---------------------------------------------HPNLVQLLGVCTREP 194 Query: 144 ISKTPALVFEYVDNVDF-RILYPKLTDLEIRFYMF-ELLKALDYCHSMGIMHRDVKPHNV 201 Y + +D+ R + + + YM ++ A++Y +HRD+ N Sbjct: 195 PFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNC 254 Query: 202 MIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFG 258 ++ +N +++ D+GL+ + Y ++F + PE L Y + D+W+FG Sbjct: 255 LVG-ENHLVKVADFGLSRLMTGDT-YTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFG 311 Query: 259 TML 261 +L Sbjct: 312 VLL 314 >6NPU-A nrPDB Length = 298 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 44/237 (18%), Positives = 96/237 (40%), Gaps = 50/237 (21%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK--PVKKKKIKREIKILTDLS 90 W D +++K+G G+Y EV++GV + + +K LK ++ ++ +E ++ ++ Sbjct: 21 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 80 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII-KDPISKTPA 149 H N++ L + ++P Sbjct: 81 ---------------------------------------HPNLVQLLGVCTREPPFYIIT 101 Query: 150 LVFEYVDNVDF-RILYPKLTDLEIRFYMF-ELLKALDYCHSMGIMHRDVKPHNVMIDHKN 207 Y + +D+ R + + + YM ++ A++Y +HRD+ N ++ +N Sbjct: 102 EFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG-EN 160 Query: 208 KKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTML 261 +++ D+GL+ + Y ++F + PE L Y + D+W+FG +L Sbjct: 161 HLVKVADFGLSRLMTGDT-YTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLL 215 >4RT7-A nrPDB Length = 415 Score = 45.4 bits (106), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 27/98 (27%), Positives = 52/98 (53%), Gaps = 5/98 (5%) Query: 167 LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME 226 LT ++ + +++ K +++ +HRD+ NV++ H K +++ D+GLA + Sbjct: 240 LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH-GKVVKICDFGLARDIMSDSN 298 Query: 227 YNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTML 261 Y VR +R + PE L + +Y D+WS+G +L Sbjct: 299 YVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYGILL 335 >5B2L-A nrPDB Length = 324 Score = 45.1 bits (105), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 28/113 (24%), Positives = 56/113 (49%), Gaps = 6/113 (5%) Query: 179 LLKALDYC-HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFK 237 ++KAL Y G++HRDVKP N+++D + +++L D+G++ + + Sbjct: 125 IVKALYYLKEKHGVIHRDVKPSNILLDERG-QIKLCDFGISGRLVDSKAKTRSAGCAAYM 183 Query: 238 GPELL----VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVK 286 PE + YD D+WS G L + + P+ + ++ + L K+++ Sbjct: 184 APERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQ 236 >5U6B-A nrPDB Length = 307 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 36/166 (21%), Positives = 76/166 (45%), Gaps = 18/166 (10%) Query: 130 HANIIHLFDIIKDPISK----TPALVFEYVDNVDFR--ILYPKLTDLEIRF-------YM 176 H N++ L + + P ++ ++ + D +LY +L D + +M Sbjct: 83 HPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFM 142 Query: 177 FELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAE-FYHVNMEYNVRVASRF 235 ++ ++Y + +HRD+ N M++ +N + + D+GL++ Y+ + R+A Sbjct: 143 ADIASGMEYLSTKRFIHRDLAARNCMLN-ENMSVCVADFGLSKKIYNGDYYRQGRIAKMP 201 Query: 236 FK--GPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTD 279 K E L D R+Y D+WSFG + + + + + G N++ Sbjct: 202 VKWIAIESLAD-RVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSE 246 >5L6P-A nrPDB Length = 298 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 55/250 (22%), Positives = 103/250 (41%), Gaps = 48/250 (19%) Query: 41 EIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLP 100 +IE +G G++ EV +G LK ++++ IK L Sbjct: 22 KIEEVIGAGEFGEVCRG------------RLKQPGRREVFVAIKTL-------------- 55 Query: 101 FQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDF 160 K Y Q+ D L I Q H NII L ++ S+ ++ E+++N Sbjct: 56 --KVGYTERQRRDFLS--EASIMGQFD--HPNIIRLEGVVTK--SRPVMILTEFMENCAL 107 Query: 161 ----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWG 216 R+ + T +++ + + + Y M +HRD+ N+++ + N ++ D+G Sbjct: 108 DSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILV-NSNLVCKVSDFG 166 Query: 217 LAEFYH---VNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFG-TMLASMIFKRE 269 L+ F + Y + + + PE + YR + + D+WS+G M M + Sbjct: 167 LSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIA-YRKFTSASDVWSYGIVMWEVMSYGER 225 Query: 270 PFFHGTSNTD 279 P++ SN D Sbjct: 226 PYWD-MSNQD 234 >5H2U-A nrPDB Length = 267 Score = 44.7 bits (104), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 54/261 (20%), Positives = 114/261 (43%), Gaps = 63/261 (24%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP---VKKKKIKREIKILTDLSNEKV 94 +++ + K+G G + EVF+G+ D +V++ IK++ + ++ ++ EI+ + L Sbjct: 6 EEFTLCRKLGSGYFGEVFEGLWKD-RVQVAIKVISRDNLLHQQMLQSEIQAMKKLR---- 60 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIK--DPISKTPAL-- 150 H +I+ L+ ++ DP+ L Sbjct: 61 -----------------------------------HKHILALYAVVSVGDPVYIITELMA 85 Query: 151 ---VFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN 207 + E + + D ++L P L+I + + E + Y S +HRD+ N+++ +N Sbjct: 86 KGSLLELLRDSDEKVL-PVSELLDIAWQVAE---GMCYLESQNYIHRDLAARNILVG-EN 140 Query: 208 KKLRLIDWGLA----EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLAS 263 ++ D+GLA E +++ ++N+ + PE L Y D+WSFG +L Sbjct: 141 TLCKVGDFGLARLIKEDVYLSHDHNIPYK---WTAPEAL-SRGHYSTKSDVWSFGILLHE 196 Query: 264 MIFKREPFFHGTSNTDQLVKI 284 M + + + G SN + +++ Sbjct: 197 MFSRGQVPYPGMSNHEAFLRV 217 >3UIU-A nrPDB Length = 306 Score = 44.7 bits (104), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 24/89 (26%), Positives = 50/89 (56%), Gaps = 4/89 (4%) Query: 178 ELLKALDYCHSMGIMHRDVKPHNV-MIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFF 236 ++ K +DY HS ++HRD+KP N+ ++D K++++ D+GL + + + + Sbjct: 144 QITKGVDYIHSKKLIHRDLKPSNIFLVD--TKQVKIGDFGLVTSLKNDGKRTRSKGTLRY 201 Query: 237 KGPELLVDYRMYDYSLDLWSFGTMLASMI 265 PE + + Y +DL++ G +LA ++ Sbjct: 202 MSPE-QISSQDYGKEVDLYALGLILAELL 229 >4G3E-A nrPDB Length = 352 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 49/109 (44%), Gaps = 8/109 (7%) Query: 174 FYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVAS 233 +Y+ + L+ L+Y H+ I+H DVK NV++ + L D+G A + + Sbjct: 170 YYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTG 229 Query: 234 RFFKGPEL-----LVDYRMYDYSLDLWSFGTMLASMIFKREP---FFHG 274 + G E +V + D +D+WS M+ M+ P +F G Sbjct: 230 DYIPGTETHMAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRG 278 >3G0E-A nrPDB Length = 336 Score = 44.3 bits (103), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 54/281 (19%), Positives = 116/281 (41%), Gaps = 46/281 (16%) Query: 46 VGRGKYSEVFQG-----VKLDSKVKIVIKMLKP----VKKKKIKREIKILTDLSNEKVPP 96 +G G + +V + +K D+ + + +KMLKP +++ + E+K+L+ L N Sbjct: 54 LGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIV 113 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP--ISKT-PALVFE 153 L P + + + ++++ +D SKT PA++ + Sbjct: 114 NLL-------------GACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMED 160 Query: 154 YVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLI 213 L ++ + +++ K + + S +HRD+ N+++ H + ++ Sbjct: 161 DEL---------ALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTH-GRITKIC 210 Query: 214 DWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 D+GLA + Y V+ +R + PE + + +Y + D+WS+G L + Sbjct: 211 DFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNC-VYTFESDVWSYGIFLWELFSLGSS 269 Query: 271 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDM 311 + G + K++K E + + P E YD+ Sbjct: 270 PYPGMPVDSKFYKMIK-------EGFRMLSPEHAPAEMYDI 303 >2W1I-A nrPDB Length = 326 Score = 44.3 bits (103), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 32/140 (22%), Positives = 69/140 (49%), Gaps = 10/140 (7%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK----LTDLEIRFYMFELLKALDY 185 H NI+ + + L+ EY+ R K + +++ Y ++ K ++Y Sbjct: 101 HDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEY 160 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME-YNVRVASR---FFKGPEL 241 + +HRD+ N++++++N ++++ D+GL + + E Y V+ F+ PE Sbjct: 161 LGTKRYIHRDLATRNILVENEN-RVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPES 219 Query: 242 LVDYRMYDYSLDLWSFGTML 261 L + + + + D+WSFG +L Sbjct: 220 LTESK-FSVASDVWSFGVVL 238 >2FO0-A nrPDB Length = 495 Score = 44.3 bits (103), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 46/243 (18%), Positives = 94/243 (38%), Gaps = 62/243 (25%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--------VKKKKIKREIK 84 W D +++K+G G+Y EV++GV + + +K LK +K+ + +EIK Sbjct: 212 WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK 271 Query: 85 ILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII-KDP 143 H N++ L + ++P Sbjct: 272 ---------------------------------------------HPNLVQLLGVCTREP 286 Query: 144 ISKTPALVFEYVDNVDF-RILYPKLTDLEIRFYMF-ELLKALDYCHSMGIMHRDVKPHNV 201 Y + +D+ R + + + YM ++ A++Y +HR++ N Sbjct: 287 PFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNC 346 Query: 202 MIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFG 258 ++ +N +++ D+GL+ + Y ++F + PE L Y + D+W+FG Sbjct: 347 LVG-ENHLVKVADFGLSRLMTGDT-YTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFG 403 Query: 259 TML 261 +L Sbjct: 404 VLL 406 >3PPZ-A nrPDB Length = 309 Score = 44.3 bits (103), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 42/165 (25%), Positives = 80/165 (48%), Gaps = 15/165 (9%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVD-FRILYPKLT----DLEIRFYM-FELLKAL 183 H NI+ + P + + +V EY+ +R+L+ D R M +++ K + Sbjct: 93 HPNIVLFMGAVTQPPNLS--IVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGM 150 Query: 184 DYCHSMG--IMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVN-MEYNVRVASRFFKGPE 240 +Y H+ I+HRD+K N+++D K +++ D+GL+ + + + PE Sbjct: 151 NYLHNRNPPIVHRDLKSPNLLVD-KKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPE 209 Query: 241 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIV 285 +L D + S D++SFG +L + ++P+ G N Q+V V Sbjct: 210 VLRDEPSNEKS-DVYSFGVILWELATLQQPW--GNLNPAQVVAAV 251 >3IO7-A nrPDB Length = 313 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 32/140 (22%), Positives = 69/140 (49%), Gaps = 10/140 (7%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK----LTDLEIRFYMFELLKALDY 185 H NI+ + + L+ EY+ R K + +++ Y ++ K ++Y Sbjct: 88 HDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEY 147 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME-YNVRVASR---FFKGPEL 241 + +HRD+ N++++++N ++++ D+GL + + E Y V+ F+ PE Sbjct: 148 LGTKRYIHRDLATRNILVENEN-RVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPES 206 Query: 242 LVDYRMYDYSLDLWSFGTML 261 L + + + + D+WSFG +L Sbjct: 207 LTESK-FSVASDVWSFGVVL 225 >5M07-A nrPDB Length = 276 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 23/78 (29%), Positives = 43/78 (55%), Gaps = 8/78 (10%) Query: 150 LVFEYVDNVD----FRILYPKLTDL-EIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID 204 + +YVD +D +P + + E+ + + ALDY H G++HRDV P NV++ Sbjct: 107 IAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYAHQRGLLHRDVNPANVVLT 166 Query: 205 HKN---KKLRLIDWGLAE 219 ++ +++ L D+G+A Sbjct: 167 SQSAGDQRILLADFGIAS 184 >4Y83-A nrPDB Length = 332 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 30/110 (27%), Positives = 54/110 (49%), Gaps = 12/110 (10%) Query: 167 LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME 226 + + EI + +LK LD+ HS ++H D+KP N++ + K L+D+GL+ V M Sbjct: 162 MREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVF--MSTKAVLVDFGLS----VQMT 215 Query: 227 YNVRV-----ASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 +V + + PE+++ R + D++S G L M P+ Sbjct: 216 EDVYFPKDLRGTEIYMSPEVIL-CRGHSTKADIYSLGATLIHMQTGTPPW 264 >2WTK-B nrPDB Length = 373 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 34/115 (29%), Positives = 55/115 (47%), Gaps = 12/115 (10%) Query: 167 LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK--------KLRLIDWGLA 218 + +L I + + +LKALDY H MG +HR VK +++I K L +I G Sbjct: 109 MNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQR 168 Query: 219 E-FYHVNMEYNVRVASRFFKGPELL-VDYRMYDYSLDLWSFGTMLASMIFKREPF 271 + H +Y+V+V + PE+L + + YD D++S G + PF Sbjct: 169 QRVVHDFPKYSVKVLP--WLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPF 221 >4PDO-A nrPDB Length = 299 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 57/266 (21%), Positives = 104/266 (39%), Gaps = 46/266 (17%) Query: 18 QRTEEYWDYENTVIDWSTNTKDYEIENK--VGRGKYSEVFQGVKLDSKVKIVIKMLKPVK 75 Q Y D V+ ++T + + +G G++ EV++G Sbjct: 12 QDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKG------------------ 53 Query: 76 KKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIH 135 +L S +K P + K Y Q+ D L I Q H NII Sbjct: 54 ---------MLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLG--EAGIMGQ--FSHHNIIR 100 Query: 136 LFDIIKDPISKTPALVFEYVDNVDF-RILYPK---LTDLEIRFYMFELLKALDYCHSMGI 191 L +I K ++ EY++N + L K + L++ + + + Y +M Sbjct: 101 LEGVISK--YKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKYLANMNY 158 Query: 192 MHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASR----FFKGPELLVDYRM 247 +HRD+ N++++ N ++ D+GL+ + E + + PE + YR Sbjct: 159 VHRDLAARNILVN-SNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEA-ISYRK 216 Query: 248 YDYSLDLWSFG-TMLASMIFKREPFF 272 + + D+WSFG M M + P++ Sbjct: 217 FTSASDVWSFGIVMWEVMTYGERPYW 242 >3QGY-A nrPDB Length = 286 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 30/143 (20%), Positives = 69/143 (48%), Gaps = 20/143 (13%) Query: 130 HANIIHLFDIIKDPISKTP-ALVFEYVDNVDF-------RILYPKLTDLEIRFYMFELLK 181 H ++ L+ + + + P LVFE++++ R L+ T L + ++ + Sbjct: 81 HPKLVQLYGVC---LEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGM---CLDVCE 134 Query: 182 ALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKG 238 + Y ++HRD+ N ++ +N+ +++ D+G+ F ++ +Y ++F + Sbjct: 135 GMAYLEEACVIHRDLAARNCLVG-ENQVIKVSDFGMTRFV-LDDQYTSSTGTKFPVKWAS 192 Query: 239 PELLVDYRMYDYSLDLWSFGTML 261 PE+ + Y D+WSFG ++ Sbjct: 193 PEVF-SFSRYSSKSDVWSFGVLM 214 >2XYN-A nrPDB Length = 292 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 46/250 (18%), Positives = 95/250 (38%), Gaps = 62/250 (24%) Query: 26 YENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--------VKKK 77 Y ++ W D +++K+G G+Y EV+ GV + + +K LK +K+ Sbjct: 20 YFQSMDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEA 79 Query: 78 KIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLF 137 + +EIK H N++ L Sbjct: 80 AVMKEIK---------------------------------------------HPNLVQLL 94 Query: 138 DIIK-DPISKTPALVFEYVDNVDF--RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHR 194 + +P Y + +D+ ++T + + + ++ A++Y +HR Sbjct: 95 GVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHR 154 Query: 195 DVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYS 251 D+ N ++ +N +++ D+GL+ + Y ++F + PE L Y + Sbjct: 155 DLAARNCLVG-ENHVVKVADFGLSRLMTGDT-YTAHAGAKFPIKWTAPESLA-YNTFSIK 211 Query: 252 LDLWSFGTML 261 D+W+FG +L Sbjct: 212 SDVWAFGVLL 221 >4UYA-A nrPDB Length = 340 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 33/152 (21%), Positives = 67/152 (44%), Gaps = 12/152 (7%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHS- 188 H NII L + L F ++ + ++ + + ++ + + Y H Sbjct: 84 HPNIIELRGVCLQQPHLCLVLEFARGGALNRALAGRRIPPHVLVNWAVQIARGMLYLHEE 143 Query: 189 --MGIMHRDVKPHNVMI-------DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGP 239 + I+HRD+K N+++ D NK L++ D+GLA +H + A + P Sbjct: 144 AFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAGAYAWM-AP 202 Query: 240 ELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 E+ + ++ D+WS+G +L ++ P+ Sbjct: 203 EV-IKSSLFSKGSDIWSYGVLLWELLTGEVPY 233 >4TPT-A nrPDB Length = 303 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 46/163 (28%), Positives = 78/163 (47%), Gaps = 34/163 (20%) Query: 130 HANIIHLFDII-KDPISKTPALVFEYVDNV---DF-RILYPKLTDLEIRFYMFELLKALD 184 H N++ ++ KD K L+ EY++ DF R + P ++RF + + Sbjct: 56 HPNVLKFIGVLYKD---KKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAK-GIASGMA 111 Query: 185 YCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-----EFYHVNME------------- 226 Y HSM I+HRD+ HN +I +K + + D+GL+ E ME Sbjct: 112 YLHSMCIIHRDLNSHNCLI-KLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKND 170 Query: 227 ----YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 Y V V + ++ PE+L + + YD ++D++SFG +L +I Sbjct: 171 RKKRYTV-VGNPYWMAPEML-NGKSYDETVDIFSFGIVLCEII 211 >5L2Q-C nrPDB Length = 320 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 36/196 (18%), Positives = 87/196 (44%), Gaps = 41/196 (20%) Query: 166 KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNM 225 +L++ E +++++ ++ H I+HRD+K N++++ + ++ + ++ L + H+ Sbjct: 149 RLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGK--HLVS 206 Query: 226 EYNV---RVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLV 282 E ++ + S + P++L D+W+ G +L +M++ + PF+ Sbjct: 207 EGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYD--------- 257 Query: 283 KIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDN 342 ++P+E + + I+ + DG ++ + LI Sbjct: 258 --------------------SIPQELF---RKIKAAEYTIPEDGRV----SENTVCLIRK 290 Query: 343 LLRYDHQERLTAKEAM 358 LL D Q+RL A + + Sbjct: 291 LLVLDPQQRLAAADVL 306 >4JLC-A nrPDB Length = 657 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 40/177 (22%), Positives = 79/177 (44%), Gaps = 23/177 (12%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK------LTDLEIRFYMFELLKAL 183 H NI+ LF I ++ ++ L+ E+ + + L + E + +++ + Sbjct: 65 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 124 Query: 184 DYCHSMGIMHRDVKPHNVM--IDHKNKKL-RLIDWGLAEFYHVNMEYNVRVASRFFKGPE 240 ++ GI+HRD+KP N+M I + + +L D+G A + ++ + + P+ Sbjct: 125 NHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 184 Query: 241 ------LLVDY-RMYDYSLDLWSFGTML-----ASMIFKREPFFHGTSNTDQLVKIV 285 L D+ + Y ++DLWS G S+ F+ PF N + + KI+ Sbjct: 185 MYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFR--PFEGPRRNKEVMYKII 239 >3C1X-A nrPDB Length = 373 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 53/237 (22%), Positives = 98/237 (41%), Gaps = 50/237 (21%) Query: 46 VGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQ 105 +GRG + V+ G LD+ KKI +K L +++ Sbjct: 97 IGRGHFGCVYHGTLLDND------------GKKIHCAVKSLNRITDIG------------ 132 Query: 106 YYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILY- 164 +V +F+ I + + H N++ L I +P +V Y+ + D R Sbjct: 133 -------EVSQFLTEGIIMKDFS-HPNVLSLLGICLRS-EGSPLVVLPYMKHGDLRNFIR 183 Query: 165 -----PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA- 218 P + DL I F + ++ K + + S +HRD+ N M+D K +++ D+GLA Sbjct: 184 NETHNPTVKDL-IGFGL-QVAKGMKFLASKKFVHRDLAARNCMLDEKF-TVKVADFGLAR 240 Query: 219 -----EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 EF V+ + ++ ++ L + + D+WSFG +L ++ + P Sbjct: 241 DMYDKEFDSVHNKTGAKLPVKWMALESL--QTQKFTTKSDVWSFGVLLWELMTRGAP 295 >2CMW-A nrPDB Length = 310 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 29/94 (30%), Positives = 44/94 (46%), Gaps = 23/94 (24%) Query: 143 PISKTPALVFEYVDNVDFRILYPKLTDL-----------EIRFYMFELLKALDYCHSMGI 191 P K A+V E +L P L DL + +LL ++Y HS + Sbjct: 67 PCGKYNAMVLE--------LLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNL 118 Query: 192 MHRDVKPHNVMIDHKNKK----LRLIDWGLAEFY 221 ++RDVKP N +I + K + +ID+GLA+ Y Sbjct: 119 IYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEY 152 >4IX6-A nrPDB Length = 350 Score = 42.0 bits (97), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 21/46 (45%), Positives = 28/46 (60%), Gaps = 1/46 (2%) Query: 176 MFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK-LRLIDWGLAEF 220 M ELL +L H G++HRDVKP N++ K+ L+LID G A Sbjct: 149 MRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAAL 194 >1AD5-A nrPDB Length = 438 Score = 42.0 bits (97), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 51/253 (20%), Positives = 104/253 (41%), Gaps = 58/253 (22%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--VKKKKIKREIKILTDLS 90 W + ++E K+G G++ EV+ + K+ +K +KP + + E ++ L Sbjct: 177 WEIPRESLKLEKKLGAGQFGEVWMAT-YNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQ 235 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 ++K+ K+ Y II + ++K L Sbjct: 236 HDKLVKLHAVVTKEPIY-------------------------------IITEFMAKGSLL 264 Query: 151 VFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 F D + L PKL D + ++ + + + +HRD++ N+++ + Sbjct: 265 DFLKSDEGSKQPL-PKLID-----FSAQIAEGMAFIEQRNYIHRDLRAANILVS-ASLVC 317 Query: 211 RLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMI-F 266 ++ D+GLA RV ++F + PE +++ + D+WSFG +L ++ + Sbjct: 318 KIADFGLA-----------RVGAKFPIKWTAPEA-INFGSFTIKSDVWSFGILLMEIVTY 365 Query: 267 KREPFFHGTSNTD 279 R P + G SN + Sbjct: 366 GRIP-YPGMSNPE 377 >2A1A-B nrPDB Length = 284 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 23/89 (25%), Positives = 50/89 (56%), Gaps = 4/89 (4%) Query: 178 ELLKALDYCHSMGIMHRDVKPHNV-MIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFF 236 ++ K +DY HS +++RD+KP N+ ++D K++++ D+GL + + + + Sbjct: 130 QITKGVDYIHSKKLINRDLKPSNIFLVD--TKQVKIGDFGLVTSLKNDGKRTRSKGTLRY 187 Query: 237 KGPELLVDYRMYDYSLDLWSFGTMLASMI 265 PE + + Y +DL++ G +LA ++ Sbjct: 188 MSPE-QISSQDYGKEVDLYALGLILAELL 215 >3BBT-B nrPDB Length = 328 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 32/124 (25%), Positives = 58/124 (46%), Gaps = 13/124 (10%) Query: 151 VFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 V E+ DN+ ++L + ++ K + Y ++HRD+ NV++ N + Sbjct: 107 VHEHKDNIGSQLLL---------NWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPN-HV 156 Query: 211 RLIDWGLAEFYHVN-MEYNVRVASRFFKGPEL-LVDYRMYDYSLDLWSFG-TMLASMIFK 267 ++ D+GLA + EYN K L + YR + + D+WS+G T+ M F Sbjct: 157 KITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFG 216 Query: 268 REPF 271 +P+ Sbjct: 217 GKPY 220 >4CI6-B nrPDB Length = 643 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 24/72 (33%), Positives = 35/72 (48%), Gaps = 4/72 (5%) Query: 172 IRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRV 231 I+F LL ++ GI+H D+KP NV+ D + + +ID GL H + Sbjct: 158 IKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGL----HSRSGEQPKG 213 Query: 232 ASRFFKGPELLV 243 + FK PEL V Sbjct: 214 FTESFKAPELGV 225 >6NT9-A nrPDB Length = 742 Score = 41.6 bits (96), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 39/177 (22%), Positives = 79/177 (44%), Gaps = 23/177 (12%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK------LTDLEIRFYMFELLKAL 183 H NI+ LF I ++ ++ L+ E+ + + L + E + +++ + Sbjct: 64 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 123 Query: 184 DYCHSMGIMHRDVKPHNVM--IDHKNKKL-RLIDWGLAEFYHVNMEYNVRVASRFFKGPE 240 ++ GI+HR++KP N+M I + + +L D+G A + ++ + + P+ Sbjct: 124 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 183 Query: 241 ------LLVDY-RMYDYSLDLWSFGTML-----ASMIFKREPFFHGTSNTDQLVKIV 285 L D+ + Y ++DLWS G S+ F+ PF N + + KI+ Sbjct: 184 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR--PFEGPRRNKEVMYKII 238 >5AMN-A nrPDB Length = 299 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 25/102 (24%), Positives = 54/102 (52%), Gaps = 5/102 (4%) Query: 167 LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME 226 LT ++ + +++ + + Y M ++HRD+ N+++ + +K+++ D+GL+ + Sbjct: 133 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV-AEGRKMKISDFGLSRDVYEEDS 191 Query: 227 YNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 Y R R + E L D+ +Y D+WSFG +L ++ Sbjct: 192 YVKRSQGRIPVKWMAIESLFDH-IYTTQSDVWSFGVLLWEIV 232 >4EUU-A nrPDB Length = 319 Score = 40.8 bits (94), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 38/175 (21%), Positives = 77/175 (44%), Gaps = 19/175 (10%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK------LTDLEIRFYMFELLKAL 183 H NI+ LF I ++ ++ L+ E+ + + L + E + +++ + Sbjct: 66 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 125 Query: 184 DYCHSMGIMHRDVKPHNVM--IDHKNKKL-RLIDWGLAEFYHVNMEYNVRVASRFFKGPE 240 ++ GI+HR++KP N+M I + + +L D+G A + ++ + + P+ Sbjct: 126 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 185 Query: 241 ------LLVDY-RMYDYSLDLWSFGTML---ASMIFKREPFFHGTSNTDQLVKIV 285 L D+ + Y ++DLWS G A+ PF N + + KI+ Sbjct: 186 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 240 >5FM2-A nrPDB Length = 355 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 25/102 (24%), Positives = 54/102 (52%), Gaps = 5/102 (4%) Query: 167 LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME 226 LT ++ + +++ + + Y M ++HRD+ N+++ + +K+++ D+GL+ + Sbjct: 188 LTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILV-AEGRKMKISDFGLSRDVYEEDS 246 Query: 227 YNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 Y R R + E L D+ +Y D+WSFG +L ++ Sbjct: 247 YVKRSQGRIPVKWMAIESLFDH-IYTTQSDVWSFGVLLWEIV 287 >6O8B-A nrPDB Length = 665 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 39/177 (22%), Positives = 79/177 (44%), Gaps = 23/177 (12%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK------LTDLEIRFYMFELLKAL 183 H NI+ LF I ++ ++ L+ E+ + + L + E + +++ + Sbjct: 72 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 131 Query: 184 DYCHSMGIMHRDVKPHNVM--IDHKNKKL-RLIDWGLAEFYHVNMEYNVRVASRFFKGPE 240 ++ GI+HR++KP N+M I + + +L D+G A + ++ + + P+ Sbjct: 132 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPD 191 Query: 241 ------LLVDY-RMYDYSLDLWSFGTML-----ASMIFKREPFFHGTSNTDQLVKIV 285 L D+ + Y ++DLWS G S+ F+ PF N + + KI+ Sbjct: 192 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFR--PFEGPRRNKEVMYKII 246 >4EUT-A nrPDB Length = 396 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 38/175 (21%), Positives = 77/175 (44%), Gaps = 19/175 (10%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK------LTDLEIRFYMFELLKAL 183 H NI+ LF I ++ ++ L+ E+ + + L + E + +++ + Sbjct: 66 HKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGM 125 Query: 184 DYCHSMGIMHRDVKPHNVM--IDHKNKKL-RLIDWGLAEFYHVNMEYNVRVASRFFKGPE 240 ++ GI+HR++KP N+M I + + +L D+G A + ++ + + P+ Sbjct: 126 NHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPD 185 Query: 241 ------LLVDY-RMYDYSLDLWSFGTML---ASMIFKREPFFHGTSNTDQLVKIV 285 L D+ + Y ++DLWS G A+ PF N + + KI+ Sbjct: 186 MYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 240 >4BTF-A nrPDB Length = 469 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 38/160 (23%), Positives = 71/160 (44%), Gaps = 17/160 (10%) Query: 123 FDQPHNGHANIIHLFDIIKDPISKTP--ALVFEYVDNVDFRILYPKLTDLEIRFYMFELL 180 FD P NI+ +F I D K P ++V EY + R L + DL + +L Sbjct: 251 FDSP-----NILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVL 305 Query: 181 KA---LDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYH-----VNMEYNVRVA 232 +A L H +HR++ + ++ +++L + L++ + R + Sbjct: 306 RAARGLYRLHHSETLHRNISSSSFLV-AGGYQVKLAGFELSKTQNSISRTAKSTKAERSS 364 Query: 233 SRFFKGPELLVD-YRMYDYSLDLWSFGTMLASMIFKREPF 271 S + PE L + + +YD +++SFG +L + + PF Sbjct: 365 STIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPF 404 >4M7I-A nrPDB Length = 299 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 23/103 (22%), Positives = 52/103 (50%), Gaps = 15/103 (14%) Query: 177 FELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME---------- 226 ++ +A+++ HS G+MHRD+KP N+ + +++ D+GL + E Sbjct: 125 LQIAEAVEFLHSKGLMHRDLKPSNIFFTM-DDVVKVGDFGLVTAMDQDEEEQTVLTPMPA 183 Query: 227 ---YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 + +V ++ + PE + Y + +D++S G +L +++ Sbjct: 184 YARHTGQVGTKLYMSPE-QIHGNSYSHKVDIFSLGLILFELLY 225 >2Y4I-B nrPDB Length = 319 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 32/113 (28%), Positives = 48/113 (42%), Gaps = 14/113 (12%) Query: 112 EDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLE 171 ED LK + + H N++ P P L R LY + D + Sbjct: 70 EDQLKAFKREVMAYRQTRHENVVLFMGACMSP----PHLAI-ITSLCKGRTLYSVVRDAK 124 Query: 172 I-------RFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGL 217 I R E++K + Y H+ GI+H+D+K NV D N K+ + D+GL Sbjct: 125 IVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYD--NGKVVITDFGL 175 >2RIO-A nrPDB Length = 434 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 46/220 (20%), Positives = 91/220 (41%), Gaps = 61/220 (27%) Query: 178 ELLKALDYCHSMGIMHRDVKPHNVMID------------HKNKKLRLIDWGLAE------ 219 ++ + + HS+ I+HRD+KP N+++ +N ++ + D+GL + Sbjct: 123 QIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQ 182 Query: 220 -FYHVNMEYNVRVASRFFKGPELLVDY------RMYDYSLDLWSFGTMLASMIFK-REPF 271 + N+ N + ++ PELL + R S+D++S G + ++ K + PF Sbjct: 183 SSFRTNL--NNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF 240 Query: 272 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLS 331 S ++ R + +D+ K H ++ L Sbjct: 241 GDKYSRESNII-----------------------RGIFSLDEM--KCLH------DRSLI 269 Query: 332 GNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIE 371 E DLI ++ +D +R TA + + HP F P +++E Sbjct: 270 A--EATDLISQMIDHDPLKRPTAMKVLRHPLFWPKSKKLE 307 >4M69-B nrPDB Length = 283 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 38/160 (23%), Positives = 71/160 (44%), Gaps = 17/160 (10%) Query: 123 FDQPHNGHANIIHLFDIIKDPISKTP--ALVFEYVDNVDFRILYPKLTDLEIRFYMFELL 180 FD P NI+ +F I D K P ++V EY + R L + DL + +L Sbjct: 65 FDSP-----NILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVL 119 Query: 181 KA---LDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYH-----VNMEYNVRVA 232 +A L H +HR++ + ++ +++L + L++ + R + Sbjct: 120 RAARGLYRLHHSETLHRNISSSSFLV-AGGYQVKLAGFELSKTQNSISRTAKSTKAERSS 178 Query: 233 SRFFKGPELLVD-YRMYDYSLDLWSFGTMLASMIFKREPF 271 S + PE L + + +YD +++SFG +L + + PF Sbjct: 179 STIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPF 218 >1FVR-A nrPDB Length = 327 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 58/303 (19%), Positives = 124/303 (40%), Gaps = 49/303 (16%) Query: 30 VIDWSTNTKDYEIENKVGRGKYSEVFQ------GVKLDSKVKIVIKMLKPVKKKKIKREI 83 V+DW+ D + ++ +G G + +V + G+++D+ +K + + + E+ Sbjct: 21 VLDWN----DIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGEL 76 Query: 84 KILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP 143 ++L L + L + + Y L Y PH +L D ++ Sbjct: 77 EVLCKLGHHPNIINLLGACEHRGY-------LYLAIEY---APHG------NLLDFLRKS 120 Query: 144 --ISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNV 201 + PA L+ ++ + ++ + +DY +HRD+ N+ Sbjct: 121 RVLETDPAFAIA-------NSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNI 173 Query: 202 MIDHKNKKLRLIDWGLAEFYHVNMEYNV-RVASRFFKGPELLVDYRMYDYSLDLWSFGTM 260 ++ +N ++ D+GL+ V ++ + R+ R+ L +Y +Y + D+WS+G + Sbjct: 174 LVG-ENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESL--NYSVYTTNSDVWSYGVL 230 Query: 261 LASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYD-MDQYIR-KP 318 L ++ + G + + K+ + Y L+ + E YD M Q R KP Sbjct: 231 LWEIVSLGGTPYCGMTCAELYEKLP--------QGYRLEKPLNCDDEVYDLMRQCWREKP 282 Query: 319 WHR 321 + R Sbjct: 283 YER 285 >3QD2-B nrPDB Length = 332 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 23/104 (22%), Positives = 52/104 (50%), Gaps = 15/104 (14%) Query: 177 FELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME---------- 226 ++ +A+++ HS G+MHRD+KP N+ + +++ D+GL + E Sbjct: 171 IQIAEAVEFLHSKGLMHRDLKPSNIFFT-MDDVVKVGDFGLVTAMDQDEEEQTVLTPMPA 229 Query: 227 ---YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 + +V ++ + PE + Y + +D++S G +L +++ Sbjct: 230 YATHTGQVGTKLYMSPE-QIHGNNYSHKVDIFSLGLILFELLYS 272 >5X5O-A nrPDB Length = 310 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 38/153 (24%), Positives = 73/153 (47%), Gaps = 19/153 (12%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLT-------DLE-IRFYMFELLK 181 H NII + +I +P +V EY LY + D++ I + ++ K Sbjct: 63 HRNIIQFYGVILEP--PNYGIVTEYAS---LGSLYDYINSNRSEEMDMDHIMTWATDVAK 117 Query: 182 ALDYCH---SMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKG 238 + Y H + ++HRD+K NV+I + L++ D+G + F H + + V + + Sbjct: 118 GMHYLHMEAPVKVIHRDLKSRNVVIA-ADGVLKICDFGASRF-HNHTTHMSLVGTFPWMA 175 Query: 239 PELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 PE++ + + + D +S+G +L M+ + PF Sbjct: 176 PEVIQSLPVSE-TCDTYSYGVVLWEMLTREVPF 207 >2QKW-B nrPDB Length = 321 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 28/97 (28%), Positives = 50/97 (51%), Gaps = 11/97 (11%) Query: 181 KALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKG-- 238 + L Y H+ I+HRDVK N+++D +N ++ D+G+++ E + S KG Sbjct: 150 RGLHYLHTRAIIHRDVKSINILLD-ENFVPKITDFGISK---KGTELDQTHLSTVVKGTL 205 Query: 239 ----PELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 PE + R+ + S D++SFG +L ++ R Sbjct: 206 GYIDPEYFIKGRLTEKS-DVYSFGVVLFEVLCARSAI 241 >5FQD-C nrPDB Length = 341 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 27/76 (35%), Positives = 39/76 (51%), Gaps = 13/76 (17%) Query: 162 ILYPKLTDL----EIRFYMF-------ELLKALDYCHSMGIMHRDVKPHNVM--IDHKNK 208 +L P L DL RF M +++ ++Y H+ +HRD+KP N + I Sbjct: 96 LLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCN 155 Query: 209 KLRLIDWGLAEFYHVN 224 KL LID+GLA+ Y N Sbjct: 156 KLFLIDFGLAKKYRDN 171 >2C47-A nrPDB Length = 313 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 41/189 (21%), Positives = 76/189 (40%), Gaps = 44/189 (23%) Query: 39 DYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKK--KIKREIKILTDLSNEKVPP 96 ++ + K+G G + E+ G L + + IK L+P+K + ++ E + LS + P Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLSATEGVP 63 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 F Y VL+ + P + D LFD+ + L+ Sbjct: 64 QVYYFGPCGKYNAM---VLELLGPSLED-----------LFDLCDRTFTLKTVLMI---- 105 Query: 157 NVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK----LRL 212 +L+ ++Y H+ +++RDVKP N ++ K + + Sbjct: 106 -------------------AIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHI 146 Query: 213 IDWGLAEFY 221 ID+GLA+ Y Sbjct: 147 IDFGLAKEY 155 >4M66-A nrPDB Length = 325 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 52/241 (21%), Positives = 95/241 (39%), Gaps = 61/241 (25%) Query: 46 VGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQ 105 VG+G + VF+ + +K+ V KKI E+K + +L NE Sbjct: 28 VGKGGFGVVFRAHHRTWNHDVAVKI---VNSKKISWEVKAMVNLRNE------------- 71 Query: 106 YYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD---PISKTPALVFEYVDNVDFRI 162 N++ L + +D ALV +++N Sbjct: 72 --------------------------NVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAG 105 Query: 163 LY----PKLTDLEIRFYMFELLKALDYCHSM--GIMHRDVKPHNVMIDHKNKKLRLIDWG 216 L P+ L R + E++ + Y HS+ ++HRD+KP N+++D + +L D+G Sbjct: 106 LLQPEAPRPWPLLCRL-LQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHA-KLADFG 163 Query: 217 LAEF-------YHVNMEYNVRVASRFFKGPELLVDYRM-YDYSLDLWSFGTMLASMIFKR 268 L+ F + + PELL + + D++SFG ++ +++ R Sbjct: 164 LSTFQGGSQSGSGSGSGSRDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGR 223 Query: 269 E 269 E Sbjct: 224 E 224 >3PP0-A nrPDB Length = 338 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 26/111 (23%), Positives = 57/111 (51%), Gaps = 8/111 (7%) Query: 166 KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVN- 224 +L ++ + ++ K + Y + ++HRD+ NV++ N +++ D+GLA ++ Sbjct: 115 RLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPN-HVKITDFGLARLLDIDE 173 Query: 225 MEYNV---RVASRFFKGPELLVDYRMYDYSLDLWSFG-TMLASMIFKREPF 271 EY+ +V ++ +L R + + D+WS+G T+ M F +P+ Sbjct: 174 TEYHADGGKVPIKWMALESIL--RRRFTHQSDVWSYGVTVWELMTFGAKPY 222 >4C59-A nrPDB Length = 340 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 41/199 (20%), Positives = 84/199 (42%), Gaps = 35/199 (17%) Query: 108 TNQKEDVLKFIRPYIFDQPHNGHANIIHLFDI--IKDPISKTPALVF------------E 153 +N++E I+ F + +GH NI+ I S T F E Sbjct: 62 SNEEEKNRAIIQEVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVE 121 Query: 154 YVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSM--GIMHRDVKPHNVMIDHKNKKLR 211 ++ ++ R P D ++ + ++ +A+ + H I+HRD+K N+++ ++ ++ Sbjct: 122 FLKKMESR--GPLSCDTVLKIF-YQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGT-IK 177 Query: 212 LIDWGLAEFYHVNMEYN-------------VRVASRFFKGPELLVDYRMYDYS--LDLWS 256 L D+G A +Y+ R + ++ PE++ Y + D+W+ Sbjct: 178 LCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWA 237 Query: 257 FGTMLASMIFKREPFFHGT 275 G +L + F++ PF G Sbjct: 238 LGCILYLLCFRQHPFEDGA 256 >3ZBF-A nrPDB Length = 322 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 51/246 (20%), Positives = 103/246 (41%), Gaps = 35/246 (14%) Query: 46 VGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQ 105 +G G + EV++G +D + V +IK +K L S ++ + F K+ Sbjct: 41 LGSGAFGEVYEGTAVD---------ILGVGSGEIKVAVKTLKKGSTDQ---EKIEFLKEA 88 Query: 106 YYTNQ--KEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRIL 163 + ++ ++LK + + ++P ++ D++ Y+ Sbjct: 89 HLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLT------------YLRKARMATF 136 Query: 164 Y-PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN----KKLRLIDWGLA 218 Y P LT +++ ++ K Y M +HRD+ N ++ K+ + +++ D+GLA Sbjct: 137 YGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLA 196 Query: 219 EFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGT 275 + N Y R + PE L+D ++ D+WSFG ++ ++ + Sbjct: 197 RDIYKNDYYRKRGEGLLPVRWMAPESLMD-GIFTTQSDVWSFGILIWEILTLGHQPYPAH 255 Query: 276 SNTDQL 281 SN D L Sbjct: 256 SNLDVL 261 >3LZB-A nrPDB Length = 327 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 25/100 (25%), Positives = 51/100 (51%), Gaps = 4/100 (4%) Query: 175 YMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHV-NMEYNVRVAS 233 + ++ K ++Y ++HRD+ NV++ + +++ D+GLA+ EY+ Sbjct: 122 WCVQIAKGMNYLEDRRLVHRDLAARNVLVK-TPQHVKITDFGLAKLLGAEEKEYHAEGGK 180 Query: 234 RFFKGPEL-LVDYRMYDYSLDLWSFG-TMLASMIFKREPF 271 K L + +R+Y + D+WS+G T+ M F +P+ Sbjct: 181 VPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPY 220 >4LRM-A nrPDB Length = 334 Score = 38.5 bits (88), Expect = 0.005, Method: Compositional matrix adjust. Identities = 25/100 (25%), Positives = 51/100 (51%), Gaps = 4/100 (4%) Query: 175 YMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHV-NMEYNVRVAS 233 + ++ K ++Y ++HRD+ NV++ + +++ D+GLA+ EY+ Sbjct: 129 WCVQIAKGMNYLEDRRLVHRDLAARNVLV-KTPQHVKITDFGLAKLLGAEEKEYHAEGGK 187 Query: 234 RFFKGPEL-LVDYRMYDYSLDLWSFG-TMLASMIFKREPF 271 K L + +R+Y + D+WS+G T+ M F +P+ Sbjct: 188 VPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPY 227 >4NFN-A nrPDB Length = 309 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 31/105 (29%), Positives = 48/105 (45%), Gaps = 13/105 (12%) Query: 178 ELLKALDYCHSMGIMHRDVKPHNVMIDH---KNKKLRLIDWGLAEFYHVNMEYNVRVASR 234 ++L++++ HS+G +HRD+KP N + +K ++D+GLA Y N +VR R Sbjct: 126 QILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQY-TNTTGDVR-PPR 183 Query: 235 FFKGPELLVDY--------RMYDYSLDLWSFGTMLASMIFKREPF 271 G V Y R DLWS ML + P+ Sbjct: 184 NVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPW 228 >5GNK-A nrPDB Length = 297 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 25/100 (25%), Positives = 51/100 (51%), Gaps = 4/100 (4%) Query: 175 YMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHV-NMEYNVRVAS 233 + ++ K ++Y ++HRD+ NV++ + +++ D+GLA+ EY+ Sbjct: 126 WCVQIAKGMNYLEDRRLVHRDLAARNVLVK-TPQHVKITDFGLAKLLGAEEKEYHAEGGK 184 Query: 234 RFFKGPEL-LVDYRMYDYSLDLWSFG-TMLASMIFKREPF 271 K L + +R+Y + D+WS+G T+ M F +P+ Sbjct: 185 VPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPY 224 >4NT4-A nrPDB Length = 312 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 21/61 (34%), Positives = 38/61 (62%), Gaps = 5/61 (8%) Query: 178 ELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK----LRLIDWGLAEFYHVNMEYNVRVAS 233 +LL ++Y HS +++RDVKP N +I + K + +ID+GLA+ Y ++++ N + Sbjct: 122 QLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEY-IDLDTNRHIPY 180 Query: 234 R 234 R Sbjct: 181 R 181 >4BTK-A nrPDB Length = 337 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 31/105 (29%), Positives = 48/105 (45%), Gaps = 13/105 (12%) Query: 178 ELLKALDYCHSMGIMHRDVKPHNVMIDH---KNKKLRLIDWGLAEFYHVNMEYNVRVASR 234 ++L++++ HS+G +HRD+KP N + +K ++D+GLA Y N +VR R Sbjct: 161 QILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQY-TNTTGDVR-PPR 218 Query: 235 FFKGPELLVDY--------RMYDYSLDLWSFGTMLASMIFKREPF 271 G V Y R DLWS ML + P+ Sbjct: 219 NVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPW 263 >2CHL-A nrPDB Length = 351 Score = 37.7 bits (86), Expect = 0.007, Method: Compositional matrix adjust. Identities = 27/94 (28%), Positives = 42/94 (44%), Gaps = 23/94 (24%) Query: 143 PISKTPALVFEYVDNVDFRILYPKLTDL-----------EIRFYMFELLKALDYCHSMGI 191 P K A+V E +L P L DL + +L+ ++Y HS + Sbjct: 96 PCGKYNAMVLE--------LLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNL 147 Query: 192 MHRDVKPHNVMIDHKNKK----LRLIDWGLAEFY 221 ++RDVKP N +I K + +ID+ LA+ Y Sbjct: 148 IYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEY 181 >4YFF-A nrPDB Length = 311 Score = 37.7 bits (86), Expect = 0.007, Method: Compositional matrix adjust. Identities = 30/133 (22%), Positives = 67/133 (50%), Gaps = 9/133 (6%) Query: 149 ALVFEYVDNVD-FRILYP--KLTDLEIRFYM-FELLKALDYCHSMG--IMHRDVKPHNVM 202 A+V +Y+ F +L+ ++ DL+ + + ++ K ++Y H++ I+HRD+ HN++ Sbjct: 117 AIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNIL 176 Query: 203 IDHKNKKLRLIDWGLAEFYHVNMEYNV--RVASRFFKGPELLVDYRMYDYSLDLWSFGTM 260 + +++ + D+G + F E N+ + + + PE+ Y D++S+ Sbjct: 177 L-YEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYALC 235 Query: 261 LASMIFKREPFFH 273 L ++ PF H Sbjct: 236 LWEILTGEIPFAH 248 >3V5Q-A nrPDB Length = 297 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 35/151 (23%), Positives = 70/151 (46%), Gaps = 17/151 (11%) Query: 178 ELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF-- 235 ++ + Y S +HRD+ N ++ N +++ D+G++ + Y V + Sbjct: 141 QIASGMVYLASQHFVHRDLATRNCLVG-ANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPI 199 Query: 236 -FKGPELLVDYRMYDYSLDLWSFGTMLASMI-FKREPFFHGTSNTDQLVKIVKVLGTSDF 293 + PE ++ YR + D+WSFG +L + + ++P+F SNT+ + I Sbjct: 200 RWMPPESIM-YRKFTTESDVWSFGVILWEIFTYGKQPWFQ-LSNTEVIECIT-------- 249 Query: 294 EKYLLKYEITLPREFYD--MDQYIRKPWHRF 322 + +L+ P+E YD + + R+P R Sbjct: 250 QGRVLERPRVCPKEVYDVMLGCWQREPQQRL 280 >2X7G-A nrPDB Length = 389 Score = 37.7 bits (86), Expect = 0.009, Method: Compositional matrix adjust. Identities = 69/328 (21%), Positives = 133/328 (40%), Gaps = 77/328 (23%) Query: 105 QYYTNQKEDVLKFIRPYIFDQPHNGHAN-IIHLFDIIKDPISKTPA----LVFEYVDNVD 159 Q+YT D +K ++ P + + + ++ L D K IS +VFE + + Sbjct: 68 QHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFK--ISGMNGIHVCMVFEVLGHHL 125 Query: 160 FRIL----YPKLTDLEIRFYMFELLKALDYCHS-MGIMHRDVKPHNVM------------ 202 + + Y L ++ + ++L+ LDY HS I+H D+KP N++ Sbjct: 126 LKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMA 185 Query: 203 -------------------------------IDHKNK---KLRLIDWGLAEFYHVNMEYN 228 +D +N ++++ D G A + H + + Sbjct: 186 AEATEWQKAGAPPPSGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTED 245 Query: 229 VRVASRFFKGPELLVDYRMYDYSLDLWSFGTM---LASMIFKREPFFHG--TSNTDQLVK 283 ++ +R ++ E+L+ Y D+WS M LA+ + EP + + D + Sbjct: 246 IQ--TRQYRSIEVLIGAG-YSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAH 302 Query: 284 IVKVLGTSDFEKYLLKYEITLPREFYDMDQYIR-----KPWHRFINDGNKHLSGNDEIID 338 I+++LG+ + L + + REF++ +R KPW F K+ +++ Sbjct: 303 IIELLGSIP-RHFALSGKYS--REFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQ 359 Query: 339 LIDNL---LRYDHQERLTAKEAMGHPWF 363 D L L ++R +A E + HPW Sbjct: 360 FTDFLIPMLEMVPEKRASAGECLRHPWL 387 >3QUP-A nrPDB Length = 323 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 24/108 (22%), Positives = 51/108 (47%), Gaps = 5/108 (4%) Query: 175 YMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASR 234 +M ++ ++Y S +HRD+ N M+ ++ + + D+GL+ + Y AS+ Sbjct: 142 FMVDIACGMEYLSSRNFIHRDLAARNCML-AEDMTVCVADFGLSRKIYSGDYYRQGCASK 200 Query: 235 F---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTD 279 + E L D +Y D+W+FG + ++ + + + G N + Sbjct: 201 LPVKWLALESLAD-NLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAE 247 >4XLV-A nrPDB Length = 328 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 33/127 (25%), Positives = 61/127 (48%), Gaps = 12/127 (9%) Query: 165 PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA------ 218 P T E+ E+ + Y ++ +HRD+ N M+ H + +++ D+G+ Sbjct: 147 PPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH-DFTVKIGDFGMTRDIYET 205 Query: 219 EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNT 278 ++Y + + V + PE L D ++ S D+WSFG +L + E + G SN Sbjct: 206 DYYRKGGKGLLPVR---WMAPESLKD-GVFTTSSDMWSFGVVLWEITSLAEQPYQGLSN- 260 Query: 279 DQLVKIV 285 +Q++K V Sbjct: 261 EQVLKFV 267 >4TN6-A nrPDB Length = 318 Score = 37.4 bits (85), Expect = 0.010, Method: Compositional matrix adjust. Identities = 43/186 (23%), Positives = 76/186 (40%), Gaps = 42/186 (22%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKK--KIKREIKILTDLSNEKVPPT 97 Y + K+G G + +++ G + + ++ IK L+ VK K ++ E KI + PT Sbjct: 9 YRLGRKIGSGSFGDIYLGTDIAAGEEVAIK-LECVKTKHPQLHIESKIYKMMQGGVGIPT 67 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 + Y V++ + P + D LF+ S L+ Sbjct: 68 IRWCGAEGDYNVM---VMELLGPSLED-----------LFNFCSRKFSLKTVLL------ 107 Query: 158 VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM--IDHKNKKLRLIDW 215 L D +++ ++Y HS +HRDVKP N + + K + +ID+ Sbjct: 108 ---------LAD--------QMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDF 150 Query: 216 GLAEFY 221 GLA+ Y Sbjct: 151 GLAKKY 156 >5VC6-A nrPDB Length = 289 Score = 37.4 bits (85), Expect = 0.011, Method: Compositional matrix adjust. Identities = 41/174 (23%), Positives = 74/174 (42%), Gaps = 39/174 (22%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVK-LDSKVKIVIKMLKP----VKKKKIKREIKILTDLS 90 T+ +E+E K+G G++ VF+ VK LD + + + KP V ++ RE+ L Sbjct: 10 TTEFHELE-KIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLG 68 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 +Y++ ED I+ N + N L D I + Sbjct: 69 QHS--------HVVRYFSAWAEDDHMLIQ--------NEYCNGGSLADAISE-------- 104 Query: 151 VFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID 204 ++RI+ + E++ + ++ + L Y HSM ++H D+KP N+ I Sbjct: 105 --------NYRIM-SYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFIS 149 >5VDK-A nrPDB Length = 297 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 42/169 (24%), Positives = 72/169 (42%), Gaps = 35/169 (20%) Query: 41 EIENKVGRGKYSEVFQGVK-LDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 E+E K+G G++ V++ +K LD V IKR +K T+LSNE + L Sbjct: 19 EVE-KIGVGEFGTVYKCIKRLDGCVY------------AIKRSMKTFTELSNEN---SAL 62 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVD 159 V+++ + D H+ II++ +L +N Sbjct: 63 HEVYAHAVLGHHPHVVRYYSSWAEDD---------HM--IIQNEYCNGGSLQAAISENTK 111 Query: 160 FRILY--PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK 206 + PKL D+ + ++ L+Y H+ ++H D+KP N+ I HK Sbjct: 112 SGNHFEEPKLKDI-----LLQISLGLNYIHNSSMVHLDIKPSNIFICHK 155 >5CLR-A nrPDB Length = 451 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 15/46 (32%), Positives = 28/46 (60%), Gaps = 1/46 (2%) Query: 171 EIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWG 216 E+ M + + H +G++HRD+KP N+M+D + + L+D+G Sbjct: 177 EVLGIMISVCHQVKQFHELGLIHRDLKPGNIMLD-ADMQCHLVDFG 221 >5WNO-A nrPDB Length = 330 Score = 37.0 bits (84), Expect = 0.014, Method: Compositional matrix adjust. Identities = 48/252 (19%), Positives = 95/252 (37%), Gaps = 42/252 (16%) Query: 41 EIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLP 100 +++ K+G G + VF G+ + K N K+P Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAK-------------------------NVKIPVAIKV 59 Query: 101 FQKDQYYTNQK-EDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVD 159 FQ DQ T++ E+ R H N++ + ++ + N+ Sbjct: 60 FQTDQSQTDEMLEEATNMFRLR--------HDNLLKIIGFCMHDDGLKIVTIYRPLGNLQ 111 Query: 160 --FRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGL 217 ++ L E Y +++ + Y ++HRD+ NV++ N + + D+GL Sbjct: 112 NFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFN-HVEITDFGL 170 Query: 218 AEFY-HVNMEYNVRVASRFFKGPEL-LVDYRMYDYSLDLWSFGTMLASMI-FKREPFFHG 274 ++ H ++ K + + Y ++ D+W+FG +I F + P + G Sbjct: 171 SKILKHDADSITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSP-YQG 229 Query: 275 TSNTDQLVKIVK 286 S TD + +K Sbjct: 230 MS-TDSIHNFLK 240 >4O1O-A nrPDB Length = 717 Score = 36.6 bits (83), Expect = 0.016, Method: Compositional matrix adjust. Identities = 16/43 (37%), Positives = 23/43 (53%) Query: 165 PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN 207 P D R + L KA+ H G H+D++P N++ID KN Sbjct: 437 PNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKN 479 >3SXS-A nrPDB Length = 268 Score = 36.2 bits (82), Expect = 0.025, Method: Compositional matrix adjust. Identities = 20/88 (22%), Positives = 48/88 (54%), Gaps = 6/88 (6%) Query: 177 FELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF- 235 +++ + + + S +HRD+ N ++D ++ +++ D+G+ Y ++ +Y V ++F Sbjct: 111 YDVCEGMAFLESHQFIHRDLAARNCLVD-RDLCVKVSDFGMTR-YVLDDQYVSSVGTKFP 168 Query: 236 --FKGPELLVDYRMYDYSLDLWSFGTML 261 + PE+ Y Y D+W+FG ++ Sbjct: 169 VKWSAPEVF-HYFKYSSKSDVWAFGILM 195 >5LPZ-A nrPDB Length = 332 Score = 35.8 bits (81), Expect = 0.027, Method: Compositional matrix adjust. Identities = 21/83 (25%), Positives = 43/83 (51%), Gaps = 5/83 (6%) Query: 191 IMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHV---NMEYNVRVASRFFKGPELLVDYRM 247 I+HRD+K NV++D +N + R+ D+G+A ++ + + + PE +R Sbjct: 141 IIHRDMKSSNVLLD-ENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRC 199 Query: 248 YDYSLDLWSFGTMLASMIFKREP 270 D++S+G +L ++ + P Sbjct: 200 STKG-DVYSYGVVLLELLTGKRP 221 >1K9A-A nrPDB Length = 450 Score = 35.8 bits (81), Expect = 0.027, Method: Compositional matrix adjust. Identities = 50/247 (20%), Positives = 97/247 (39%), Gaps = 55/247 (22%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK-PVKKKKIKREIKILTDLSN 91 W+ N K+ ++ +G+G++ +V G +KV +K +K + E ++T L Sbjct: 188 WALNMKELKLLQTIGKGEFGDVMLGDYRGNKV--AVKCIKNDATAQAFLAEASVMTQLR- 244 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H+N++ L +I + +V Sbjct: 245 --------------------------------------HSNLVQLLGVIVEEKGGL-YIV 265 Query: 152 FEY------VDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 EY VD + R D ++F + ++ +A++Y +HRD+ NV++ Sbjct: 266 TEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL-DVCEAMEYLEGNNFVHRDLAARNVLVSE 324 Query: 206 KNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASM- 264 N ++ D+GL + + + + PE L + + S D+WSFG +L + Sbjct: 325 DNVA-KVSDFGLTK--EASSTQDTGKLPVKWTAPEALREKKFSTKS-DVWSFGILLWEIY 380 Query: 265 IFKREPF 271 F R P+ Sbjct: 381 SFGRVPY 387 >5X18-A nrPDB Length = 295 Score = 35.8 bits (81), Expect = 0.029, Method: Compositional matrix adjust. Identities = 42/186 (22%), Positives = 80/186 (43%), Gaps = 40/186 (21%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 Y+I K+G G + +F+G + + V + IK +P K T Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIK-FEPRK---------------------TEA 46 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVD 159 P +D+Y T + + I PY + G NI+ + D + + +F++ Sbjct: 47 PQLRDEYKTYKILNGTPNI-PYAYYFGQEGLHNIL-----VIDLLGPSLEDLFDWCGRK- 99 Query: 160 FRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK----KLRLIDW 215 + T +++ M L++ L H+ +++RD+KP N +I + + LID+ Sbjct: 100 ----FSVKTVVQVAVQMITLIEDL---HAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDF 152 Query: 216 GLAEFY 221 G+A+ Y Sbjct: 153 GMAKQY 158 >3SV0-A nrPDB Length = 483 Score = 35.8 bits (81), Expect = 0.030, Method: Compositional matrix adjust. Identities = 14/46 (30%), Positives = 30/46 (65%), Gaps = 2/46 (4%) Query: 178 ELLKALDYCHSMGIMHRDVKPHNVM--IDHKNKKLRLIDWGLAEFY 221 +++ +++ HS +HRD+KP N + + + ++ +ID+GLA+ Y Sbjct: 111 QMINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKY 156 >5LPV-A nrPDB Length = 296 Score = 35.8 bits (81), Expect = 0.031, Method: Compositional matrix adjust. Identities = 21/83 (25%), Positives = 43/83 (51%), Gaps = 5/83 (6%) Query: 191 IMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHV---NMEYNVRVASRFFKGPELLVDYRM 247 I+HRD+K NV++D +N + R+ D+G+A ++ + + + PE +R Sbjct: 141 IIHRDMKSSNVLLD-ENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRC 199 Query: 248 YDYSLDLWSFGTMLASMIFKREP 270 D++S+G +L ++ + P Sbjct: 200 STKG-DVYSYGVVLLELLTGKRP 221 >4HZS-A nrPDB Length = 341 Score = 35.4 bits (80), Expect = 0.039, Method: Compositional matrix adjust. Identities = 42/193 (21%), Positives = 79/193 (40%), Gaps = 23/193 (11%) Query: 114 VLKFIRPYIFDQPHN--------------GHANIIHLFDIIKDPISKTPALVFEYVDNVD 159 +K ++P + QP H N+I L+ ++ P K + +D Sbjct: 44 AVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLD 103 Query: 160 -FRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA 218 R + Y ++ + + Y S +HRD+ N+++ ++ +++ D+GL Sbjct: 104 RLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDL-VKIGDFGLM 162 Query: 219 EFYHVNMEYNVRVASR----FFKGPELLVDYRMYDYSLDLWSFGTMLASM-IFKREPFFH 273 N ++ V R + PE L R + ++ D W FG L M + +EP+ Sbjct: 163 RALPQNDDHYVMQEHRKVPFAWCAPESL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWI- 220 Query: 274 GTSNTDQLVKIVK 286 G + + L KI K Sbjct: 221 GLNGSQILHKIDK 233 >1BYG-A nrPDB Length = 278 Score = 35.4 bits (80), Expect = 0.041, Method: Compositional matrix adjust. Identities = 50/247 (20%), Positives = 97/247 (39%), Gaps = 55/247 (22%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK-PVKKKKIKREIKILTDLSN 91 W+ N K+ ++ +G+G++ +V G +KV +K +K + E ++T L Sbjct: 16 WALNMKELKLLQTIGKGEFGDVMLGDYRGNKV--AVKCIKNDATAQAFLAEASVMTQLR- 72 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H+N++ L +I + +V Sbjct: 73 --------------------------------------HSNLVQLLGVIVEEKGGL-YIV 93 Query: 152 FEY------VDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 EY VD + R D ++F + ++ +A++Y +HRD+ NV++ Sbjct: 94 TEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL-DVCEAMEYLEGNNFVHRDLAARNVLVSE 152 Query: 206 KNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASM- 264 N ++ D+GL + + + + PE L + + S D+WSFG +L + Sbjct: 153 DNVA-KVSDFGLTK--EASSTQDTGKLPVKWTAPEALREKKFSTKS-DVWSFGILLWEIY 208 Query: 265 IFKREPF 271 F R P+ Sbjct: 209 SFGRVPY 215 >5IKW-A nrPDB Length = 310 Score = 35.4 bits (80), Expect = 0.045, Method: Compositional matrix adjust. Identities = 43/188 (22%), Positives = 78/188 (41%), Gaps = 22/188 (11%) Query: 105 QYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTP---ALVFEY-----VD 156 + Y N D+ R + +GH NI+ D + IS ++ EY V Sbjct: 45 RMYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVV 104 Query: 157 NVDFRILYPKLTDLEIRFYMFELLKALDYCHSMG--IMHRDVKPHNVMIDHKNKKLRLID 214 N + L T+ E+ + +A+ H I+HRD+K N++++ + L D Sbjct: 105 NQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYV-LCD 163 Query: 215 WGLAEFYHVNME---YNV------RVASRFFKGPELLVDY--RMYDYSLDLWSFGTMLAS 263 +G A +N + NV + + ++ PE++ Y + D+W+ G +L Sbjct: 164 FGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYK 223 Query: 264 MIFKREPF 271 + F PF Sbjct: 224 LCFFTLPF 231 >4WUA-A nrPDB Length = 401 Score = 35.4 bits (80), Expect = 0.045, Method: Compositional matrix adjust. Identities = 55/248 (22%), Positives = 100/248 (40%), Gaps = 68/248 (27%) Query: 178 ELLKALDYCHS-MGIMHRDVKPHNVM---------------------------------- 202 ++L+ LDY H+ I+H D+KP N++ Sbjct: 158 QVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTA 217 Query: 203 -----------IDHKNK---KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMY 248 ++ KN K+++ D G A + H + +++ +R ++ E+L+ Y Sbjct: 218 PATAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQ--TRQYRSLEVLIG-SGY 274 Query: 249 DYSLDLWSFGTM---LASMIFKREPFFHG--TSNTDQLVKIVKVLGTSDFEKYLLKYEIT 303 + D+WS M LA+ + EP T + D + I+++LG K ++ + + Sbjct: 275 NTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVP-RKLIVAGKYS 333 Query: 304 LPREFY----DMDQYIR-KPWHRFINDGNKHLSGNDEIIDLIDNL---LRYDHQERLTAK 355 +EF+ D+ + KPW F K+ +E D L L ++R TA Sbjct: 334 --KEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAA 391 Query: 356 EAMGHPWF 363 E + HPW Sbjct: 392 ECLRHPWL 399 >4AZV-A nrPDB Length = 569 Score = 35.0 bits (79), Expect = 0.046, Method: Compositional matrix adjust. Identities = 17/38 (44%), Positives = 24/38 (63%), Gaps = 1/38 (2%) Query: 179 LLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWG 216 LL++L G H DV+P NVM+D + + RLID+G Sbjct: 348 LLRSLAALEKQGFWHDDVRPWNVMVDAR-QHARLIDFG 384 >4OTD-A nrPDB Length = 341 Score = 35.0 bits (79), Expect = 0.047, Method: Compositional matrix adjust. Identities = 37/149 (24%), Positives = 65/149 (43%), Gaps = 13/149 (8%) Query: 129 GHANIIHLFDIIKDPISKTPALVFEYVDNVD--FRILYPKLTDLEIRFYMFELLKALDYC 186 GH +++LF + P + V EY D I ++ FY ++ L + Sbjct: 73 GHPFLVNLFGCFQTP--EHVCFVMEYSAGGDLMLHIHSDVFSEPRAIFYSACVVLGLQFL 130 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF----FKGPELL 242 H I++RD+K + ++ +++ D+GL + M Y R ++ F PE+L Sbjct: 131 HEHKIVYRDLK-LDNLLLDTEGYVKIADFGLCK---EGMGYGDRTSTFCGTPEFLAPEVL 186 Query: 243 VDYRMYDYSLDLWSFGTMLASMIFKREPF 271 D Y ++D W G +L M+ PF Sbjct: 187 TDTS-YTRAVDWWGLGVLLYEMLVGESPF 214 >5XD6-A nrPDB Length = 305 Score = 35.0 bits (79), Expect = 0.049, Method: Compositional matrix adjust. Identities = 58/261 (22%), Positives = 94/261 (36%), Gaps = 54/261 (20%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPP 96 T +Y ++ +G G Y VF G+ LK K IK+ L + K P Sbjct: 21 TDNYGSKSLIGEGSYGRVFYGI------------LKSGKAAAIKK-------LDSSKQPD 61 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQP---------HNGHA-NIIHLFDIIKDPISK 146 Q ++E+V+ + Y D P NG +I+H +K Sbjct: 62 QEFLAQVSMVSRLRQENVVALLG-YCVDGPLRVLAYEYAPNGSLHDILHGRKGVK---GA 117 Query: 147 TPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMG---IMHRDVKPHNVMI 203 P V + V + + L+Y H ++HRD+K NV++ Sbjct: 118 QPGPVLSWHQRVKIAV---------------GAARGLEYLHEKANPHVIHRDIKSSNVLL 162 Query: 204 -DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF-FKGPELLVDYRMYDYSLDLWSFGTML 261 D K+ D ++ RV F + PE + + S D++SFG +L Sbjct: 163 FDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGYHAPEYAMTGTLSTKS-DVYSFGVVL 221 Query: 262 ASMIFKREPFFHGTSNTDQLV 282 ++ R+P H Q V Sbjct: 222 LELLTGRKPVDHTLPRGQQSV 242 >1U54-B nrPDB Length = 291 Score = 34.7 bits (78), Expect = 0.060, Method: Compositional matrix adjust. Identities = 42/193 (21%), Positives = 79/193 (40%), Gaps = 23/193 (11%) Query: 114 VLKFIRPYIFDQPHN--------------GHANIIHLFDIIKDPISKTPALVFEYVDNVD 159 +K ++P + QP H N+I L+ ++ P K + +D Sbjct: 50 AVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLD 109 Query: 160 -FRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA 218 R + Y ++ + + Y S +HRD+ N+++ ++ +++ D+GL Sbjct: 110 RLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDL-VKIGDFGLM 168 Query: 219 EFYHVNMEYNVRVASR----FFKGPELLVDYRMYDYSLDLWSFGTMLASM-IFKREPFFH 273 N ++ V R + PE L R + ++ D W FG L M + +EP+ Sbjct: 169 RALPQNDDHYVMQEHRKVPFAWCAPESL-KTRTFSHASDTWMFGVTLWEMFTYGQEPWI- 226 Query: 274 GTSNTDQLVKIVK 286 G + + L KI K Sbjct: 227 GLNGSQILHKIDK 239 >1U59-A nrPDB Length = 287 Score = 34.7 bits (78), Expect = 0.061, Method: Compositional matrix adjust. Identities = 22/95 (23%), Positives = 51/95 (53%), Gaps = 7/95 (7%) Query: 182 ALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME-YNVRVASRF---FK 237 + Y +HRD+ NV++ +++ ++ D+GL++ + Y R A ++ + Sbjct: 122 GMKYLEEKNFVHRDLAARNVLLVNRHYA-KISDFGLSKALGADDSYYTARSAGKWPLKWY 180 Query: 238 GPELLVDYRMYDYSLDLWSFG-TMLASMIFKREPF 271 PE +++R + D+WS+G TM ++ + ++P+ Sbjct: 181 APE-CINFRKFSSRSDVWSYGVTMWEALSYGQKPY 214 >6G4J-A nrPDB Length = 315 Score = 34.7 bits (78), Expect = 0.072, Method: Compositional matrix adjust. Identities = 15/45 (33%), Positives = 24/45 (53%) Query: 172 IRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWG 216 I M +LL +L H G + D+KP N+++ ++R ID G Sbjct: 125 IPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVG 169 >4XHH-A nrPDB Length = 403 Score = 34.3 bits (77), Expect = 0.079, Method: Compositional matrix adjust. Identities = 34/188 (18%), Positives = 75/188 (39%), Gaps = 42/188 (22%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKK--KIKREIKILTDLSNEKVP 95 + + I K+G G + +++ G L S ++ I+ L+ ++ + ++ E ++ LS Sbjct: 7 RKFRIGRKIGSGSFGDIYHGTNLISGEEVAIR-LESIRSRHPQLDYESRVYKYLSGGVGI 65 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 P F ++ Y V+ + P + D +F Y Sbjct: 66 PFIRWFGREGEYNAM---VIDLLGPSLED--------------------------LFNYC 96 Query: 156 DNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM--IDHKNKKLRLI 213 + K + + +++ + Y H +HRD+KP N + + + + +I Sbjct: 97 --------HRKFSFKTVIMLALQMICRVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVI 148 Query: 214 DWGLAEFY 221 D+GL++ Y Sbjct: 149 DFGLSKKY 156 >3UIM-A nrPDB Length = 326 Score = 34.3 bits (77), Expect = 0.086, Method: Compositional matrix adjust. Identities = 29/94 (30%), Positives = 50/94 (53%), Gaps = 13/94 (13%) Query: 184 DYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEY---NVRVASRFFKG-- 238 D+C I+HRDVK N+++D + + + + D+GLA+ M+Y +V A R G Sbjct: 149 DHCDPK-IIHRDVKAANILLDEEFEAV-VGDFGLAKL----MDYKDTHVTTAVRGTIGHI 202 Query: 239 -PELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 PE L + + + D++ +G ML +I + F Sbjct: 203 APEYLSTGKSSEKT-DVFGYGVMLLELITGQRAF 235 >3I81-A nrPDB Length = 315 Score = 34.3 bits (77), Expect = 0.086, Method: Compositional matrix adjust. Identities = 31/121 (25%), Positives = 58/121 (47%), Gaps = 12/121 (9%) Query: 178 ELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA------EFYHVNMEYNVRV 231 E+ + Y ++ +HRD+ N M+ ++ +++ D+G+ ++Y + + V Sbjct: 139 EIADGMAYLNANKFVHRDLAARNCMV-AEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV 197 Query: 232 ASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTS 291 + PE L D YS D+WSFG +L + E + G SN +Q+++ V G Sbjct: 198 R---WMSPESLKDGVFTTYS-DVWSFGVVLWEIATLAEQPYQGLSN-EQVLRFVMEGGLL 252 Query: 292 D 292 D Sbjct: 253 D 253 >4AZW-A nrPDB Length = 471 Score = 34.3 bits (77), Expect = 0.089, Method: Compositional matrix adjust. Identities = 17/38 (44%), Positives = 24/38 (63%), Gaps = 1/38 (2%) Query: 179 LLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWG 216 LL++L G H DV+P NVM+D + + RLID+G Sbjct: 348 LLRSLAALEKKGFWHDDVRPWNVMVDAR-QHARLIDFG 384 >4AT3-A nrPDB Length = 299 Score = 34.3 bits (77), Expect = 0.089, Method: Compositional matrix adjust. Identities = 54/288 (18%), Positives = 119/288 (41%), Gaps = 60/288 (20%) Query: 42 IENKVGRGKYSEVFQG-----VKLDSKVKIVIKMLKPVK---KKKIKREIKILTDLSNEK 93 ++ ++G G + +VF K+ + +K LK +K RE ++LT+L Sbjct: 17 LKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNL---- 72 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP------ISKT 147 Q E ++KF + P +I +F+ +K + Sbjct: 73 ----------------QHEHIVKFYGVCVEGDP------LIMVFEYMKHGDLNKFLRAHG 110 Query: 148 PALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN 207 P V N +LT ++ ++ + Y S +HRD+ N ++ +N Sbjct: 111 PDAVLMAEGNPP-----TELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVG-EN 164 Query: 208 KKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASM 264 +++ D+G++ + Y V + + PE ++ YR + D+WS G +L + Sbjct: 165 LLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIM-YRKFTTESDVWSLGVVLWEI 223 Query: 265 I-FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDM 311 + ++P++ ++N ++++ + + +L+ T P+E Y++ Sbjct: 224 FTYGKQPWYQLSNN--EVIECIT-------QGRVLQRPRTCPQEVYEL 262 >5U6C-A nrPDB Length = 315 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 36/163 (22%), Positives = 71/163 (43%), Gaps = 17/163 (10%) Query: 130 HANIIHLFDIIKDPISKT---PALVFEYVDNVDFR--ILY------PKLTDLEIRF-YMF 177 H N++ L + + S+ P ++ ++ D +LY PK L+ +M Sbjct: 97 HPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMV 156 Query: 178 ELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-EFYHVNMEYNVRVASRFF 236 ++ ++Y + +HRD+ N M+ + + + D+GL+ + Y + R+A Sbjct: 157 DIALGMEYLSNRNFLHRDLAARNCML-RDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPV 215 Query: 237 K--GPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSN 277 K E L D R+Y D+W+FG + + + + G N Sbjct: 216 KWIAIESLAD-RVYTSKSDVWAFGVTMWEIATRGMTPYPGVQN 257 >4FAJ-A nrPDB Length = 564 Score = 33.9 bits (76), Expect = 0.12, Method: Compositional matrix adjust. Identities = 20/54 (37%), Positives = 28/54 (51%), Gaps = 9/54 (16%) Query: 16 NKQRTEEYWDYENTVIDWSTNT------KDYEIENKVG---RGKYSEVFQGVKL 60 NK++ EEYWD ID S NT D E E K G +G+ + +G+K+ Sbjct: 390 NKKQAEEYWDKAKKEIDLSKNTSLDLLVSDGEFEKKAGEFLQGQLQDSLEGLKV 443 >5VO2-A nrPDB Length = 300 Score = 33.9 bits (76), Expect = 0.13, Method: Compositional matrix adjust. Identities = 23/100 (23%), Positives = 52/100 (52%), Gaps = 8/100 (8%) Query: 175 YMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFY---HVNMEYNVRV 231 + + ++Y H I+HRD+K N++I + + +++ D+G ++ M + V Sbjct: 105 WSMGIAGGMNYLHLHKIIHRDLKSPNMLITY-DDVVKISDFGTSKELSDKSTKMSFAGTV 163 Query: 232 ASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 A + PE++ + + + +D+WSFG +L ++ P+ Sbjct: 164 A---WMAPEVIRNEPVSE-KVDIWSFGVVLWELLTGEIPY 199 >3SOC-A nrPDB Length = 322 Score = 33.9 bits (76), Expect = 0.13, Method: Compositional matrix adjust. Identities = 27/99 (27%), Positives = 46/99 (46%), Gaps = 15/99 (15%) Query: 175 YMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA---EFYHVNMEYNVRV 231 Y+ E + L H I HRD+K NV++ + N + D+GLA E + + +V Sbjct: 136 YLHEDIPGLKDGHKPAISHRDIKSKNVLLKN-NLTACIADFGLALKFEAGKSAGDTHGQV 194 Query: 232 ASRFFKGPELL---VDYR--------MYDYSLDLWSFGT 259 +R + PE+L ++++ MY L LW + Sbjct: 195 GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELAS 233 >5TOS-A nrPDB Length = 395 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 26/102 (25%), Positives = 53/102 (51%), Gaps = 7/102 (6%) Query: 177 FELLKALDYCHS--MGIMHRDVKPHNVMIDHKNKKLRLIDWGLA-EFYHVNMEY-NVRVA 232 + K L + HS + +++RD+K N+++D + +L D+GLA + ++ Y + RV Sbjct: 182 LDAAKGLAFLHSDPVKVIYRDIKASNILLD-ADYNAKLSDFGLARDGPMGDLSYVSTRVM 240 Query: 233 SRF-FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFH 273 + + PE + + S D++SFG +L ++ + H Sbjct: 241 GTYGYAAPEYMSSGHLNARS-DVYSFGVLLLEILSGKRALDH 281 >4XHL-A nrPDB Length = 394 Score = 33.5 bits (75), Expect = 0.14, Method: Compositional matrix adjust. Identities = 35/188 (18%), Positives = 75/188 (39%), Gaps = 42/188 (22%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKK--KIKREIKILTDLSNEKVP 95 + + I K+G G + +++ G L S ++ I+ L+ ++ + ++ E ++ LS Sbjct: 7 RKFRIGRKIGSGSFGDIYHGTNLISGEEVAIR-LESIRSRHPQLDYESRVYRYLSGGVGI 65 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 P F ++ Y V+ + P + D +F Y Sbjct: 66 PFIRWFGREGEYNAM---VIDLLGPSLED--------------------------LFNYC 96 Query: 156 DNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM--IDHKNKKLRLI 213 R + + L ++ + + Y H +HRD+KP N + + + + +I Sbjct: 97 HR---RFSFKTVIMLALQMFC-----RIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVI 148 Query: 214 DWGLAEFY 221 D+GL++ Y Sbjct: 149 DFGLSKKY 156 >1CSN-A nrPDB Length = 298 Score = 33.1 bits (74), Expect = 0.19, Method: Compositional matrix adjust. Identities = 14/48 (29%), Positives = 28/48 (58%), Gaps = 4/48 (8%) Query: 178 ELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK----LRLIDWGLAEFY 221 ++L + H +++RD+KP N +I N K + ++D+G+ +FY Sbjct: 114 QMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFY 161 >4L00-A nrPDB Length = 304 Score = 33.1 bits (74), Expect = 0.20, Method: Compositional matrix adjust. Identities = 31/151 (20%), Positives = 63/151 (41%), Gaps = 15/151 (9%) Query: 129 GHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMF----ELLKALD 184 H +I++L+ + + +V E+V+ + + +D+ + F +L AL Sbjct: 90 SHKHIVYLYGVCVRDVENI--MVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALS 147 Query: 185 YCHSMGIMHRDVKPHNVMIDHKNKK------LRLIDWGLAEFYHVNMEYNVRVASRFFKG 238 Y ++H +V N+++ + ++L D G+ E R+ + Sbjct: 148 YLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIP---WIA 204 Query: 239 PELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 PE + D + + D WSFGT L + + E Sbjct: 205 PECVEDSKNLSVAADKWSFGTTLWEICYNGE 235 >2RSV-A nrPDB Length = 403 Score = 32.7 bits (73), Expect = 0.24, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 29/46 (63%), Gaps = 1/46 (2%) Query: 177 FELLKALDYCHSMGIMHRDVKPHNVMIDHKN-KKLRLIDWGLAEFY 221 +L L+Y H +H D+K N+++++KN ++ L+D+GLA Y Sbjct: 166 LRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 211 >2OZO-A nrPDB Length = 613 Score = 32.7 bits (73), Expect = 0.24, Method: Compositional matrix adjust. Identities = 21/95 (22%), Positives = 51/95 (53%), Gaps = 7/95 (7%) Query: 182 ALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEY-NVRVASRF---FK 237 + Y +HR++ NV++ +++ ++ D+GL++ + Y R A ++ + Sbjct: 448 GMKYLEEKNFVHRNLAARNVLLVNRHYA-KISDFGLSKALGADDSYYTARSAGKWPLKWY 506 Query: 238 GPELLVDYRMYDYSLDLWSFG-TMLASMIFKREPF 271 PE +++R + D+WS+G TM ++ + ++P+ Sbjct: 507 APEC-INFRKFSSRSDVWSYGVTMWEALSYGQKPY 540 >2LAV-A nrPDB Length = 361 Score = 32.7 bits (73), Expect = 0.27, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 29/46 (63%), Gaps = 1/46 (2%) Query: 177 FELLKALDYCHSMGIMHRDVKPHNVMIDHKNK-KLRLIDWGLAEFY 221 +L L+Y H +H D+K N+++++KN ++ L+D+GLA Y Sbjct: 159 LRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRY 204 >5TE0-A nrPDB Length = 347 Score = 32.0 bits (71), Expect = 0.41, Method: Compositional matrix adjust. Identities = 39/168 (23%), Positives = 73/168 (43%), Gaps = 27/168 (16%) Query: 128 NGHANIIHLFDIIKDPISKTPALVFEYVDNVDF----RILYPKLTDLEIRFYMFELLKA- 182 +GH NI+ D + +S V+E + +DF +++ L+ F E+L+ Sbjct: 73 SGHKNIVGYIDSSINNVSS--GDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIF 130 Query: 183 LDYCHSMG--------IMHRDVKPHNVMIDHKNKKLRLIDWGLA--EFYHVNMEYNVRVA 232 D C ++ I+HRD+K N+++ H L D+G A +F + E V Sbjct: 131 CDTCEAVARLHQCKTPIIHRDLKVENILL-HDRGHYVLCDFGSATNKFQNPQTEGVNAVE 189 Query: 233 SRF-------FKGPELLVDY--RMYDYSLDLWSFGTMLASMIFKREPF 271 ++ PE++ Y ++ D+W+ G +L + + PF Sbjct: 190 DEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF 237 >5KMM-A nrPDB Length = 329 Score = 32.0 bits (71), Expect = 0.44, Method: Compositional matrix adjust. Identities = 37/181 (20%), Positives = 78/181 (43%), Gaps = 31/181 (17%) Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDF-RILYPKLTDL-----------------E 171 H +I+ F + + + +VFEY+ + D R L D + Sbjct: 96 HQHIVRFFGVCTE--GRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQ 153 Query: 172 IRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRV 231 + ++ + Y + +HRD+ N ++ + +++ D+G++ + Y RV Sbjct: 154 LLAVASQVAAGMVYLAGLHFVHRDLATRNCLVG-QGLVVKIGDFGMSRDIYSTDYY--RV 210 Query: 232 ASRF-----FKGPELLVDYRMYDYSLDLWSFGTMLASMI-FKREPFFHGTSNTDQLVKIV 285 R + PE ++ YR + D+WSFG +L + + ++P++ SNT+ + I Sbjct: 211 GGRTMLPIRWMPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQPWYQ-LSNTEAIDCIT 268 Query: 286 K 286 + Sbjct: 269 Q 269 >6EWX-A nrPDB Length = 484 Score = 32.0 bits (71), Expect = 0.45, Method: Compositional matrix adjust. Identities = 14/54 (25%), Positives = 29/54 (53%) Query: 156 DNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 D+V P++ + + F + +L L++ GI+HRD+ N+++ H N + Sbjct: 196 DSVASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQ 249 >3ZZW-A nrPDB Length = 289 Score = 30.8 bits (68), Expect = 0.88, Method: Compositional matrix adjust. Identities = 39/193 (20%), Positives = 84/193 (43%), Gaps = 40/193 (20%) Query: 130 HANIIHLFDIIK--DPISKTPALVFEYVDNVDF-------------------RILYPKLT 168 H N++ L ++ P+S ++F Y + D R + L Sbjct: 71 HPNVVCLLGVVTKDQPLS----MIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALE 126 Query: 169 DLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGL------AEFYH 222 + + ++ ++Y S ++H+D+ NV++ + +++ D GL A++Y Sbjct: 127 PPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLV-YDKLNVKISDLGLFREVYAADYY- 184 Query: 223 VNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI-FKREPFFHGTSNTD-- 279 + N + R+ PE ++ Y + D+WS+G +L + + +P+ G SN D Sbjct: 185 -KLLGNSLLPIRWM-APEAIM-YGKFSIDSDIWSYGVVLWEVFSYGLQPYC-GYSNQDVV 240 Query: 280 QLVKIVKVLGTSD 292 ++++ +VL D Sbjct: 241 EMIRNRQVLPCPD 253 >4FL3-A nrPDB Length = 635 Score = 30.8 bits (68), Expect = 1.0, Method: Compositional matrix adjust. Identities = 28/137 (20%), Positives = 60/137 (43%), Gaps = 20/137 (14%) Query: 182 ALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEY-NVRVASRF---FK 237 + Y +HRD+ NV++ ++ ++ D+GL++ + Y + ++ + Sbjct: 481 GMKYLEESNFVHRDLAARNVLLVTQHYA-KISDFGLSKALRADENYYKAQTHGKWPVKWY 539 Query: 238 GPELLVDYRMYDYSLDLWSFGTML-ASMIFKREPF--FHGTSNTDQLVKIVKVLGTSDFE 294 PE ++Y + D+WSFG ++ + + ++P+ G+ T L K + Sbjct: 540 APEC-INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGER-------- 590 Query: 295 KYLLKYEITLPREFYDM 311 + PRE YD+ Sbjct: 591 ---MGCPAGCPREMYDL 604 >5UU1-A nrPDB Length = 324 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 16/47 (34%), Positives = 28/47 (59%), Gaps = 1/47 (2%) Query: 179 LLKALDYCHSMGIMHRDVKPHNVMIDHKNK-KLRLIDWGLAEFYHVN 224 +L L+Y H +H D+K N+++ +KN ++ L D+GL+ Y N Sbjct: 139 MLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPN 185 >5DMZ-A nrPDB Length = 365 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 25/110 (22%), Positives = 49/110 (44%), Gaps = 15/110 (13%) Query: 170 LEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI----------DHKNKKLRLIDWGLA- 218 L I F M +L ++ H I+H D+KP N ++ D + L LID G + Sbjct: 173 LVISFAM-RMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSI 231 Query: 219 --EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 + + + + + F+ E+L + + ++Y +D + + M+F Sbjct: 232 DMKLFPKGTIFTAKCETSGFQCVEMLSN-KPWNYQIDYFGVAATVYCMLF 280 >5UIU-A nrPDB Length = 323 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 23/88 (26%), Positives = 42/88 (47%), Gaps = 8/88 (9%) Query: 182 ALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA----EFYHVNMEYNVRVASRFFK 237 +++ H +HRD+K N+++D ++ D+GLA +F M + V + + Sbjct: 161 GINFLHENHHIHRDIKSANILLDEAFTA-KISDFGLARASEKFAQTVMTSRI-VGTTAYM 218 Query: 238 GPELLVDYRMYDYSLDLWSFGTMLASMI 265 PE L D++SFG +L +I Sbjct: 219 APEAL--RGEITPKSDIYSFGVVLLEII 244 >3LMG-A nrPDB Length = 344 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 22/101 (21%), Positives = 51/101 (50%), Gaps = 6/101 (5%) Query: 175 YMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVN---MEYNVRV 231 + ++ K + Y G++HR++ NV++ + ++++ D+G+A+ + + Y+ Sbjct: 138 WGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPS-QVQVADFGVADLLPPDDKQLLYSEAK 196 Query: 232 ASRFFKGPELLVDYRMYDYSLDLWSFG-TMLASMIFKREPF 271 + E + + Y + D+WS+G T+ M F EP+ Sbjct: 197 TPIKWMALE-SIHFGKYTHQSDVWSYGVTVWELMTFGAEPY 236 >3BYV-A nrPDB Length = 377 Score = 30.4 bits (67), Expect = 1.3, Method: Compositional matrix adjust. Identities = 42/194 (21%), Positives = 76/194 (39%), Gaps = 54/194 (27%) Query: 111 KEDVLKF--IRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRI-----L 163 KE+VL+ +R + H I FD++KDP K ++ +D D + L Sbjct: 121 KEEVLRLRLLRGIKNQKQAKVHLRFIFPFDLVKDPQKK--KMIRVRLDERDMWVLSRFFL 178 Query: 164 YPKLTD------------------------LEIRFYMFELLKALDYCHSMGIMHRDVKPH 199 YP++ L++ + LL +L H G++H ++P Sbjct: 179 YPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQLTLQVIRLLASL---HHYGLVHTYLRPV 235 Query: 200 NVMIDHKNKKLRLIDWGLAEFYHV--NMEYNVRVASRFFKGPEL-----LVDYR-----M 247 ++++D + L F H+ + V SR F+ PEL + Y + Sbjct: 236 DIVLDQRGGVF------LTGFEHLVRDGARVVSSVSRGFEPPELEARRATISYHRDRRTL 289 Query: 248 YDYSLDLWSFGTML 261 +S D W+ G ++ Sbjct: 290 MTFSFDAWALGLVI 303 >5C26-A nrPDB Length = 299 Score = 30.4 bits (67), Expect = 1.5, Method: Compositional matrix adjust. Identities = 28/137 (20%), Positives = 60/137 (43%), Gaps = 20/137 (14%) Query: 182 ALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEY-NVRVASRF---FK 237 + Y +HRD+ NV++ ++ ++ D+GL++ + Y + ++ + Sbjct: 139 GMKYLEESNFVHRDLAARNVLLVTQHYA-KISDFGLSKALRADENYYKAQTHGKWPVKWY 197 Query: 238 GPELLVDYRMYDYSLDLWSFGTML-ASMIFKREPF--FHGTSNTDQLVKIVKVLGTSDFE 294 PE ++Y + D+WSFG ++ + + ++P+ G+ T L K + Sbjct: 198 APEC-INYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGER-------- 248 Query: 295 KYLLKYEITLPREFYDM 311 + PRE YD+ Sbjct: 249 ---MGCPAGCPREMYDL 262 >4CRS-A nrPDB Length = 341 Score = 30.0 bits (66), Expect = 1.7, Method: Compositional matrix adjust. Identities = 28/102 (27%), Positives = 51/102 (50%), Gaps = 9/102 (8%) Query: 174 FYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVAS 233 FY ++ L Y H I++RD+K N+++D + +++ D+GL + M Y R ++ Sbjct: 118 FYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGF-VKIADFGLCK---EGMGYGDRTST 173 Query: 234 RF----FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 F PE+L + Y ++D W G ++ M+ PF Sbjct: 174 FCGTPEFLAPEVLTETS-YTRAVDWWGLGVLIYEMLVGESPF 214 >5J0A-A nrPDB Length = 300 Score = 29.6 bits (65), Expect = 2.4, Method: Compositional matrix adjust. Identities = 31/148 (20%), Positives = 60/148 (40%), Gaps = 10/148 (6%) Query: 177 FELLKALDYCHS-MGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYN----VRV 231 + + L Y H ++H D+K NV+I + +++ D G++ NME + Sbjct: 127 LNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYI 186 Query: 232 ASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTS 291 + +K E + + + D+++FG L M+ P + ++ K S Sbjct: 187 GTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHIN---LSNDDDDEDKTFDES 243 Query: 292 DF--EKYLLKYEITLPREFYDMDQYIRK 317 DF E Y P ++D+ +K Sbjct: 244 DFDDEAYYAALGTRPPINMEELDESYQK 271 >2AOV-A nrPDB Length = 292 Score = 29.6 bits (65), Expect = 2.5, Method: Compositional matrix adjust. Identities = 27/109 (24%), Positives = 50/109 (45%), Gaps = 24/109 (22%) Query: 252 LDLWSFGTMLASMIFKRE-----PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPR 306 L W F M+ + + ++ FFH T+ + I+ V G+S ++K KY P+ Sbjct: 133 LQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWDKLWKKYGSRFPQ 192 Query: 307 EFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNL-LRYDHQERLTA 354 + D+ QYI +D++ ++DNL L+Y+ + L+ Sbjct: 193 D--DLCQYIT----------------SDDLTQMLDNLGLKYECYDLLST 223 >4OAU-C nrPDB Length = 699 Score = 29.3 bits (64), Expect = 2.9, Method: Compositional matrix adjust. Identities = 16/44 (36%), Positives = 25/44 (56%), Gaps = 2/44 (4%) Query: 173 RFYMFELLKALDYCH-SMGIMHRDVKPHNVMIDHKNKKLRLIDW 215 R + + KA+ H S G H+D++P N++ID K K L D+ Sbjct: 442 RNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK-KAAHLADF 484 >6J6I-B nrPDB Length = 351 Score = 29.3 bits (64), Expect = 3.1, Method: Compositional matrix adjust. Identities = 45/197 (22%), Positives = 83/197 (42%), Gaps = 28/197 (14%) Query: 101 FQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD-PISKTPALVFEYVDNVD 159 F +D+ T ++ V + + + H+N + L + P P LVFE+ ++ Sbjct: 89 FSEDEI-TGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFPF---PVLVFEFAEHGA 144 Query: 160 FRILYPKLTDLE-------IRFYMF-ELLKALDYCHSMG---IMHRDVKPHNVMIDHKNK 208 + + E +R + E+ A+ Y H+ I+HRDVKP +V +D KN Sbjct: 145 MNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLD-KNW 203 Query: 209 KLRLIDWGLAEFYHVNM-EYNVRVASRFFKGPELLVDYRMYDYSL-----DLWSFGTMLA 262 +L D + +++ E R+ + + G +D + D++SFG L Sbjct: 204 TAKLSDLS----FSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFVTEYTDVYSFGICLL 259 Query: 263 SMIFKREPFFHGTSNTD 279 +I +P S+ D Sbjct: 260 -VIITGKPAIMTISDGD 275 >6BFN-A nrPDB Length = 342 Score = 28.9 bits (63), Expect = 3.5, Method: Compositional matrix adjust. Identities = 15/42 (35%), Positives = 26/42 (61%), Gaps = 3/42 (7%) Query: 181 KALDYCH--SMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEF 220 +A+ + H S ++H D+K NV++D + +L D+GLA F Sbjct: 136 RAIQFLHQDSPSLIHGDIKSSNVLLDERLTP-KLGDFGLARF 176 >5OAT-A nrPDB Length = 411 Score = 28.9 bits (63), Expect = 3.7, Method: Compositional matrix adjust. Identities = 26/102 (25%), Positives = 47/102 (46%), Gaps = 16/102 (15%) Query: 190 GIMHRDVKPHNVMIDHKNKK---LRLIDWGLA---EFYHVNMEYNV----RVASRFFKGP 239 GI HRD+K N+++D + L + D+G + +++ Y + + P Sbjct: 173 GIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAP 232 Query: 240 ELLVD----YRMYDYS-LDLWSFGTMLASMIFKREPFFHGTS 276 E++ + + +YS DLW+ G +A IF F+G S Sbjct: 233 EIICQKPGTFSVLNYSKADLWAVGA-IAYEIFNCHNPFYGPS 273 >5VE6-A nrPDB Length = 492 Score = 28.5 bits (62), Expect = 5.1, Method: Compositional matrix adjust. Identities = 11/41 (26%), Positives = 23/41 (56%) Query: 165 PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 P+ + + F + +L L++ GI+HRD+ N+++ H Sbjct: 203 PEAYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVH 243 >5AR8-A nrPDB Length = 326 Score = 28.1 bits (61), Expect = 5.8, Method: Compositional matrix adjust. Identities = 20/80 (25%), Positives = 45/80 (56%), Gaps = 9/80 (11%) Query: 149 ALVFEYVDNVDFRILYPKLTDLE-----IRFYMF-ELLKALDYCHSMG--IMHRDVKPHN 200 +V EY+ N L + T+ +RF + E+ ++Y H+M ++H D+K N Sbjct: 108 GIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQN 167 Query: 201 VMIDHKNKKLRLIDWGLAEF 220 +++D++ +++ D+GL+++ Sbjct: 168 ILLDNEF-HVKIADFGLSKW 186 >2H34-A nrPDB Length = 309 Score = 28.1 bits (61), Expect = 6.0, Method: Compositional matrix adjust. Identities = 18/81 (22%), Positives = 36/81 (44%), Gaps = 4/81 (4%) Query: 193 HRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVN--MEYNVRVASRFFKGPELLVDYRMYDY 250 HRDVKP N+++ + L+D+G+A + V + ++ PE + Y Sbjct: 157 HRDVKPENILVSADDFAY-LVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESHAT-Y 214 Query: 251 SLDLWSFGTMLASMIFKREPF 271 D+++ +L + P+ Sbjct: 215 RADIYALTCVLYECLTGSPPY 235 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4LFI-A nrPDB 474 e-134 6O6Q-A nrPDB 347 5e-96 4MD7-E nrPDB 341 2e-94 6EII-A nrPDB 329 2e-90 6HMD-A nrPDB 328 3e-90 2PVN-A nrPDB 323 1e-88 5XVU-A nrPDB 318 2e-87 3OHT-A nrPDB 280 5e-76 4EWQ-A nrPDB 274 3e-74 3NIZ-A nrPDB 268 3e-72 4MYG-A nrPDB 267 6e-72 2BPM-A nrPDB 266 8e-72 5Z33-A nrPDB 266 1e-71 5NGU-A nrPDB 260 5e-70 6GU6-A nrPDB 259 2e-69 4QTB-A nrPDB 258 2e-69 3OZ6-A nrPDB 258 3e-69 4KRC-A nrPDB 257 6e-69 4AU8-A nrPDB 257 6e-69 1CM8-A nrPDB 257 6e-69 2F9G-A nrPDB 255 2e-68 4MVF-A nrPDB 255 2e-68 6DTL-A nrPDB 254 4e-68 1V0B-A nrPDB 253 8e-68 1G3N-A nrPDB 251 2e-67 3HZT-A nrPDB 250 9e-67 3EB0-A nrPDB 250 1e-66 1UA2-A nrPDB 250 1e-66 3DXN-A nrPDB 248 3e-66 5AIR-A nrPDB 248 4e-66 4IC8-A nrPDB 248 4e-66 3NCG-A nrPDB 247 6e-66 3GC9-A nrPDB 247 7e-66 3DFA-A nrPDB 245 3e-65 3LIJ-A nrPDB 244 4e-65 4ZSG-A nrPDB 244 5e-65 5AWM-A nrPDB 243 7e-65 4AGU-A nrPDB 243 7e-65 3MIA-A nrPDB 243 1e-64 3E7O-A nrPDB 243 1e-64 4E7W-A nrPDB 243 1e-64 5JN2-A nrPDB 243 1e-64 1JNK-A nrPDB 242 2e-64 5EFQ-A nrPDB 242 2e-64 2XS0-A nrPDB 241 4e-64 4NST-A nrPDB 241 5e-64 3Q5I-A nrPDB 240 6e-64 3FI2-A nrPDB 240 1e-63 4QNY-A nrPDB 239 2e-63 5FG8-A nrPDB 239 2e-63 2BDW-A nrPDB 238 2e-63 2VN9-A nrPDB 238 3e-63 2W4O-A nrPDB 238 4e-63 4YZB-A nrPDB 237 5e-63 2V7O-A nrPDB 237 5e-63 3MA6-A nrPDB 237 7e-63 3SOA-A nrPDB 236 8e-63 3PG1-A nrPDB 236 9e-63 5U6Y-A nrPDB 236 1e-62 3KK8-A nrPDB 235 3e-62 2Y7J-A nrPDB 235 3e-62 5G6V-A nrPDB 235 3e-62 4BBM-A nrPDB 234 4e-62 2VZ6-A nrPDB 234 4e-62 3GC0-A nrPDB 233 7e-62 2W96-B nrPDB 231 3e-61 3BHH-A nrPDB 230 6e-61 3E3P-A nrPDB 230 1e-60 3F3Z-A nrPDB 229 1e-60 2QNJ-A nrPDB 229 1e-60 5IG1-A nrPDB 229 2e-60 4REW-A nrPDB 228 2e-60 4O2Z-A nrPDB 228 2e-60 5ES1-A nrPDB 228 3e-60 2HAK-A nrPDB 228 5e-60 6C9D-A nrPDB 227 7e-60 2JC6-A nrPDB 226 1e-59 3N9X-A nrPDB 226 1e-59 3NIE-A nrPDB 226 1e-59 4CFF-A nrPDB 226 1e-59 3ZDU-A nrPDB 226 1e-59 4NIF-A nrPDB 225 3e-59 5XZW-A nrPDB 225 3e-59 5EZV-A nrPDB 224 3e-59 3MN3-A nrPDB 224 4e-59 4CFH-A nrPDB 224 4e-59 3RP9-A nrPDB 224 5e-59 4RED-A nrPDB 224 6e-59 2YAB-A nrPDB 223 9e-59 5YKS-A nrPDB 223 1e-58 2J90-A nrPDB 223 1e-58 4RGJ-A nrPDB 222 2e-58 5WAX-A nrPDB 222 2e-58 4BGQ-A nrPDB 222 2e-58 3H4J-B nrPDB 222 2e-58 2YCR-A nrPDB 222 2e-58 4FG9-A nrPDB 221 3e-58 4JG6-A nrPDB 221 4e-58 5KZ7-A nrPDB 220 6e-58 2A27-A nrPDB 220 8e-58 3I6U-A nrPDB 220 9e-58 2YZA-A nrPDB 219 1e-57 2JAM-A nrPDB 219 2e-57 3D2K-A nrPDB 219 2e-57 1ZWS-A nrPDB 218 2e-57 4UZD-A nrPDB 218 3e-57 4PDS-A nrPDB 218 4e-57 4CZT-A nrPDB 216 1e-56 5ZTN-A nrPDB 215 3e-56 2I6L-A nrPDB 214 3e-56 1PHK-A nrPDB 214 4e-56 3IS5-A nrPDB 214 5e-56 3UC3-A nrPDB 214 5e-56 5Y86-A nrPDB 214 6e-56 5JZN-A nrPDB 214 6e-56 4D28-A nrPDB 214 7e-56 3ZUT-A nrPDB 213 8e-56 3GUB-A nrPDB 213 1e-55 5YV8-A nrPDB 213 1e-55 3TAC-A nrPDB 213 2e-55 3MV5-A nrPDB 212 2e-55 2X4F-A nrPDB 212 2e-55 3UDB-A nrPDB 212 2e-55 5KCV-A nrPDB 210 6e-55 2JDO-A nrPDB 210 6e-55 3COM-A nrPDB 209 2e-54 6FDY-U nrPDB 209 2e-54 1FOT-A nrPDB 208 2e-54 2HW6-A nrPDB 208 3e-54 4JXF-A nrPDB 208 4e-54 4D2V-A nrPDB 207 5e-54 5D9K-A nrPDB 207 5e-54 6CMJ-A nrPDB 207 6e-54 1NY3-A nrPDB 206 1e-53 4L42-A nrPDB 206 1e-53 3DAK-A nrPDB 206 1e-53 3FXW-A nrPDB 205 2e-53 3HKO-A nrPDB 205 2e-53 5D7A-A nrPDB 205 2e-53 2OZA-A nrPDB 205 2e-53 4RLP-A nrPDB 205 2e-53 6FD3-A nrPDB 205 3e-53 3KA0-A nrPDB 205 3e-53 4FIE-A nrPDB 204 4e-53 4CQG-A nrPDB 204 5e-53 3UTO-A nrPDB 204 5e-53 5X8I-B nrPDB 203 7e-53 4LG4-A nrPDB 203 7e-53 4JDH-A nrPDB 203 9e-53 4YNZ-A nrPDB 203 1e-52 2Q0N-A nrPDB 203 1e-52 4XBR-A nrPDB 202 2e-52 6FYV-A nrPDB 202 2e-52 1KOA-A nrPDB 202 2e-52 6AO5-A nrPDB 201 3e-52 6CKI-A nrPDB 201 4e-52 5X3F-B nrPDB 201 4e-52 2F57-A nrPDB 201 4e-52 6E9W-A nrPDB 201 5e-52 5F9E-A nrPDB 201 5e-52 3KN6-A nrPDB 200 6e-52 2UV2-A nrPDB 200 8e-52 3TXO-A nrPDB 200 1e-51 4CSV-A nrPDB 199 2e-51 3HDN-A nrPDB 199 2e-51 5O2B-A nrPDB 198 3e-51 1KOB-A nrPDB 198 3e-51 4KS7-A nrPDB 198 4e-51 2R2P-A nrPDB 197 8e-51 3RAW-A nrPDB 196 9e-51 2Z7Q-A nrPDB 196 1e-50 4PWN-A nrPDB 196 1e-50 5N23-A nrPDB 196 1e-50 5UNP-A nrPDB 195 2e-50 5DYK-A nrPDB 195 2e-50 1VZO-A nrPDB 195 2e-50 4B8L-A nrPDB 195 2e-50 4AF3-A nrPDB 195 2e-50 3Q53-A nrPDB 194 5e-50 5UUU-A nrPDB 194 5e-50 5O2C-A nrPDB 194 6e-50 5LOH-A nrPDB 194 7e-50 4WNO-A nrPDB 193 9e-50 3PVW-A nrPDB 193 1e-49 3DKO-A nrPDB 193 1e-49 6QAU-A nrPDB 193 1e-49 3A8W-A nrPDB 193 1e-49 4P5Q-A nrPDB 192 2e-49 6E2O-A nrPDB 192 2e-49 4WB7-A nrPDB 191 3e-49 3DB8-A nrPDB 191 3e-49 5FET-A nrPDB 191 3e-49 6CCF-A nrPDB 191 3e-49 5DBX-A nrPDB 191 3e-49 4RA4-A nrPDB 191 4e-49 2OU7-A nrPDB 191 4e-49 3ORZ-A nrPDB 191 5e-49 4QMW-A nrPDB 190 6e-49 2XIK-A nrPDB 190 8e-49 4FZF-B nrPDB 190 8e-49 4J52-A nrPDB 190 1e-48 6ED6-A nrPDB 189 1e-48 3TKU-A nrPDB 189 1e-48 2H8H-A nrPDB 189 1e-48 4U41-A nrPDB 189 1e-48 5J5T-A nrPDB 189 2e-48 6GQK-A nrPDB 189 2e-48 2VWV-A nrPDB 189 2e-48 1TKI-A nrPDB 189 2e-48 6F3F-A nrPDB 189 2e-48 6HXF-B nrPDB 188 3e-48 4B6L-A nrPDB 188 3e-48 3A4O-X nrPDB 188 3e-48 4C0T-A nrPDB 188 3e-48 2PL0-A nrPDB 188 4e-48 2Y6O-A nrPDB 188 5e-48 5HI2-A nrPDB 188 5e-48 4AW2-A nrPDB 188 5e-48 5MJB-A nrPDB 187 6e-48 2XYN-A nrPDB 187 9e-48 1JPA-A nrPDB 186 9e-48 5X02-A nrPDB 186 1e-47 4PDO-A nrPDB 186 2e-47 4CRL-A nrPDB 185 2e-47 4OLI-A nrPDB 185 2e-47 2WO6-A nrPDB 185 3e-47 3PFQ-A nrPDB 184 4e-47 3G0E-A nrPDB 184 4e-47 2BRG-A nrPDB 184 5e-47 5L6P-A nrPDB 183 9e-47 2DQ7-X nrPDB 183 9e-47 5SYS-A nrPDB 183 1e-46 4XUF-A nrPDB 183 1e-46 4GS6-A nrPDB 183 1e-46 1U5R-A nrPDB 183 1e-46 2I0E-A nrPDB 183 2e-46 4F9B-A nrPDB 182 2e-46 3BEA-A nrPDB 182 2e-46 6CQF-A nrPDB 182 2e-46 3KUL-B nrPDB 182 2e-46 4XEY-B nrPDB 182 3e-46 2FO0-A nrPDB 182 3e-46 4EBW-A nrPDB 181 3e-46 6BDL-A nrPDB 181 3e-46 2OGV-A nrPDB 181 3e-46 3LM0-A nrPDB 181 3e-46 3QA8-A nrPDB 181 4e-46 2HK5-A nrPDB 181 4e-46 2WQN-A nrPDB 181 5e-46 2GCD-A nrPDB 180 8e-46 6NPU-A nrPDB 180 1e-45 5HIE-A nrPDB 180 1e-45 3KRL-A nrPDB 179 1e-45 3NYO-A nrPDB 179 1e-45 2J0K-A nrPDB 179 1e-45 5TUR-A nrPDB 179 2e-45 4I6B-A nrPDB 179 2e-45 4KIK-B nrPDB 179 2e-45 5GRN-A nrPDB 178 3e-45 4FR4-A nrPDB 178 3e-45 3BGP-A nrPDB 178 3e-45 6DBM-A nrPDB 178 3e-45 2WTK-C nrPDB 178 4e-45 2JD5-A nrPDB 178 4e-45 4X7Q-B nrPDB 178 4e-45 4R7H-A nrPDB 178 5e-45 5H2U-A nrPDB 177 5e-45 4RC3-A nrPDB 177 8e-45 5TQX-A nrPDB 176 1e-44 2VD5-A nrPDB 176 2e-44 3CJF-A nrPDB 175 3e-44 1AD5-A nrPDB 174 4e-44 4E93-A nrPDB 174 5e-44 2XNP-A nrPDB 174 6e-44 6DBN-A nrPDB 174 7e-44 3VN9-A nrPDB 173 1e-43 3M42-A nrPDB 173 1e-43 2PSQ-A nrPDB 173 1e-43 1ZXE-A nrPDB 172 2e-43 3ALO-A nrPDB 172 2e-43 4E20-A nrPDB 172 3e-43 3FME-A nrPDB 171 3e-43 3TT0-A nrPDB 171 4e-43 3PPZ-A nrPDB 171 6e-43 5A46-A nrPDB 170 8e-43 4RT7-A nrPDB 170 8e-43 4UY9-A nrPDB 169 2e-42 3DTC-A nrPDB 169 2e-42 4APC-A nrPDB 169 2e-42 3GQL-A nrPDB 169 2e-42 5EG3-A nrPDB 168 4e-42 4TNB-A nrPDB 168 4e-42 6BXI-A nrPDB 167 4e-42 5KKR-C nrPDB 167 5e-42 3DLS-A nrPDB 167 5e-42 4K33-A nrPDB 167 9e-42 3HNG-A nrPDB 167 9e-42 3EQC-A nrPDB 166 1e-41 3OMV-A nrPDB 166 2e-41 3VHK-A nrPDB 166 2e-41 3C51-A nrPDB 165 2e-41 4XCU-A nrPDB 165 3e-41 1FVR-A nrPDB 165 4e-41 4EQM-A nrPDB 164 4e-41 4UYA-A nrPDB 164 4e-41 6GVJ-A nrPDB 164 5e-41 4H1J-A nrPDB 164 6e-41 6E4F-A nrPDB 164 7e-41 4XI2-A nrPDB 164 8e-41 2W1I-A nrPDB 163 1e-40 4IAN-A nrPDB 163 1e-40 4Y93-A nrPDB 162 2e-40 3IO7-A nrPDB 162 2e-40 4YHJ-A nrPDB 161 4e-40 3ORP-A nrPDB 161 7e-40 3HMP-A nrPDB 160 8e-40 5O0Y-A nrPDB 160 9e-40 4HVI-A nrPDB 159 2e-39 3QGY-A nrPDB 159 2e-39 2ZMD-A nrPDB 158 3e-39 5AP3-A nrPDB 158 3e-39 5AMN-A nrPDB 158 3e-39 4PL5-B nrPDB 157 5e-39 4AN9-A nrPDB 157 8e-39 3UIU-A nrPDB 157 1e-38 2PMN-X nrPDB 156 1e-38 5CEK-A nrPDB 156 1e-38 6DC0-A nrPDB 156 2e-38 2RIO-A nrPDB 156 2e-38 5HLW-A nrPDB 156 2e-38 1S9I-A nrPDB 155 3e-38 5FM2-A nrPDB 155 3e-38 6HV0-A nrPDB 154 7e-38 6CTH-A nrPDB 153 9e-38 4EUU-A nrPDB 152 2e-37 3C1X-A nrPDB 152 3e-37 3PLS-A nrPDB 152 3e-37 3LLT-A nrPDB 151 3e-37 5B2L-A nrPDB 151 4e-37 2WTK-B nrPDB 151 4e-37 4EUT-A nrPDB 151 5e-37 4JLC-A nrPDB 151 5e-37 3BBT-B nrPDB 151 5e-37 5U6B-A nrPDB 150 8e-37 6NT9-A nrPDB 148 4e-36 6O8B-A nrPDB 148 5e-36 2A1A-B nrPDB 147 5e-36 4IDT-A nrPDB 147 6e-36 4G3E-A nrPDB 144 5e-35 4Y83-A nrPDB 144 5e-35 5HVK-A nrPDB 144 6e-35 5L2Q-C nrPDB 142 2e-34 4M7I-A nrPDB 142 2e-34 6B2Q-A nrPDB 142 3e-34 4X3F-A nrPDB 142 3e-34 4OW8-A nrPDB 142 3e-34 5WNL-A nrPDB 138 4e-33 4NEU-A nrPDB 137 9e-33 4TPT-A nrPDB 135 4e-32 5VD3-A nrPDB 134 6e-32 2Y4I-B nrPDB 127 7e-30 2BUJ-A nrPDB 127 1e-29 2PZI-A nrPDB 119 3e-27 4LQP-A nrPDB 118 3e-27 4Y12-A nrPDB 116 2e-26 4M69-B nrPDB 114 5e-26 4BTF-A nrPDB 114 6e-26 4JRN-A nrPDB 113 1e-25 5M07-A nrPDB 94 1e-19 2CMW-A nrPDB 92 4e-19 4IX6-A nrPDB 83 2e-16 4CI6-B nrPDB 69 2e-12 Sequences not found previously or not previously below threshold: 4OTD-A nrPDB 174 8e-44 4CRS-A nrPDB 167 5e-42 4WUA-A nrPDB 162 3e-40 3V5Q-A nrPDB 161 3e-40 2X7G-A nrPDB 161 5e-40 5VO2-A nrPDB 160 1e-39 4AT3-A nrPDB 159 2e-39 4XLV-A nrPDB 157 5e-39 5X5O-A nrPDB 155 4e-38 3ZBF-A nrPDB 155 4e-38 4HZS-A nrPDB 154 4e-38 5KMM-A nrPDB 154 5e-38 1LUF-A nrPDB 154 6e-38 6FEX-A nrPDB 154 6e-38 3SXS-A nrPDB 153 9e-38 1BYG-A nrPDB 153 1e-37 1K9A-A nrPDB 153 1e-37 1U54-B nrPDB 153 1e-37 6BSD-A nrPDB 152 3e-37 3QUP-A nrPDB 148 4e-36 3I81-A nrPDB 147 6e-36 3PP0-A nrPDB 145 3e-35 6FER-A nrPDB 145 3e-35 5U6C-A nrPDB 144 7e-35 4YFF-A nrPDB 144 8e-35 3QD2-B nrPDB 143 1e-34 3LZB-A nrPDB 143 1e-34 4LRM-A nrPDB 143 1e-34 5UIU-A nrPDB 142 3e-34 1U59-A nrPDB 141 4e-34 5GNK-A nrPDB 141 5e-34 2OZO-A nrPDB 140 8e-34 4F0G-A nrPDB 139 2e-33 4C59-A nrPDB 138 4e-33 3AOX-A nrPDB 137 1e-32 3ZZW-A nrPDB 135 2e-32 5IKW-A nrPDB 133 1e-31 3Q4U-A nrPDB 131 5e-31 4FL3-A nrPDB 131 6e-31 5TE0-A nrPDB 130 8e-31 5WNO-A nrPDB 130 8e-31 5TOS-A nrPDB 130 1e-30 5LPZ-A nrPDB 129 2e-30 5LPV-A nrPDB 129 2e-30 4M66-A nrPDB 128 4e-30 5C26-A nrPDB 128 4e-30 2QKW-B nrPDB 127 6e-30 3MY0-A nrPDB 127 9e-30 3LMG-A nrPDB 126 1e-29 3UIM-A nrPDB 126 2e-29 6J5U-C nrPDB 125 3e-29 3G2F-A nrPDB 124 6e-29 3MDY-A nrPDB 124 9e-29 5XD6-A nrPDB 121 4e-28 5AR8-A nrPDB 116 2e-26 1PY5-A nrPDB 115 2e-26 2H34-A nrPDB 114 8e-26 5E8V-A nrPDB 110 1e-24 5OAT-A nrPDB 108 4e-24 5X1R-A nrPDB 106 2e-23 5J0A-A nrPDB 106 2e-23 3SOC-A nrPDB 105 4e-23 4MWI-A nrPDB 103 1e-22 2QLU-A nrPDB 101 5e-22 3SV0-A nrPDB 100 7e-22 6BFN-A nrPDB 99 2e-21 4BTK-A nrPDB 99 3e-21 4NFN-A nrPDB 98 5e-21 5VC6-A nrPDB 98 5e-21 5X18-A nrPDB 97 1e-20 4L00-A nrPDB 95 5e-20 5UV4-A nrPDB 95 5e-20 5FQD-C nrPDB 95 5e-20 5VDK-A nrPDB 93 2e-19 4NT4-A nrPDB 92 2e-19 4TN6-A nrPDB 92 3e-19 6EQI-C nrPDB 91 1e-18 5USZ-A nrPDB 90 2e-18 2C47-A nrPDB 90 2e-18 4XHH-A nrPDB 90 2e-18 2CHL-A nrPDB 89 3e-18 4XHL-A nrPDB 87 1e-17 1CSN-A nrPDB 86 3e-17 3REP-A nrPDB 86 3e-17 6J6I-B nrPDB 82 4e-16 5C01-A nrPDB 80 2e-15 4WOV-A nrPDB 79 2e-15 5CLR-A nrPDB 74 1e-13 5UU1-A nrPDB 72 4e-13 6G4J-A nrPDB 72 5e-13 4L68-A nrPDB 71 9e-13 5DMZ-A nrPDB 70 1e-12 2RSV-A nrPDB 66 3e-11 2JII-A nrPDB 65 4e-11 2LAV-A nrPDB 65 6e-11 4I94-A nrPDB 62 3e-10 6G38-A nrPDB 55 4e-08 6EWX-A nrPDB 54 1e-07 4O1O-A nrPDB 53 2e-07 6M7Z-A nrPDB 52 3e-07 3Q60-A nrPDB 52 5e-07 4AZV-A nrPDB 51 1e-06 4AZW-A nrPDB 51 1e-06 5YK0-A nrPDB 51 1e-06 6BHC-A nrPDB 50 1e-06 5VE6-A nrPDB 49 3e-06 6EAS-A nrPDB 49 5e-06 3BYV-A nrPDB 46 2e-05 4CYJ-A nrPDB 45 5e-05 3DZO-A nrPDB 44 8e-05 5I35-A nrPDB 43 2e-04 4OAU-C nrPDB 43 2e-04 3ENH-A nrPDB 42 3e-04 5GZA-A nrPDB 41 7e-04 2W1Z-A nrPDB 40 0.001 5GZ9-A nrPDB 39 0.004 1TQM-A nrPDB 39 0.004 6FAI-l nrPDB 35 0.044 4WWA-A nrPDB 35 0.052 4BVU-A nrPDB 34 0.091 4CZY-B nrPDB 34 0.11 4BWP-A nrPDB 33 0.22 6EF6-A nrPDB 31 0.77 4GYG-A nrPDB 31 0.80 2Y0O-A nrPDB 31 0.86 4H05-A nrPDB 31 1.0 2QTV-A nrPDB 30 1.1 4FZ2-A nrPDB 30 2.0 >4LFI-A nrPDB Length = 374 Score = 474 bits (1220), Expect = e-134, Method: Composition-based stats. Identities = 372/372 (100%), Positives = 372/372 (100%) Query: 1 MKCRVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKL 60 MKCRVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKL Sbjct: 3 MKCRVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKL 62 Query: 61 DSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRP 120 DSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRP Sbjct: 63 DSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRP 122 Query: 121 YIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELL 180 YIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELL Sbjct: 123 YIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELL 182 Query: 181 KALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPE 240 KALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPE Sbjct: 183 KALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPE 242 Query: 241 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 300 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY Sbjct: 243 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 302 Query: 301 EITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGH 360 EITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGH Sbjct: 303 EITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGH 362 Query: 361 PWFAPIREQIEK 372 PWFAPIREQIEK Sbjct: 363 PWFAPIREQIEK 374 >6O6Q-A nrPDB Length = 335 Score = 347 bits (890), Expect = 5e-96, Method: Composition-based stats. Identities = 209/367 (56%), Positives = 261/367 (71%), Gaps = 40/367 (10%) Query: 5 VWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKV 64 V S +RVY ++ + + YWDY++ I W+ ++YEI K+GRGKYSEVF G+ L+ + Sbjct: 9 VQSVSRVYADVLSTKPQSYWDYDDLNIKWN-PQENYEILRKLGRGKYSEVFLGIDLEKRE 67 Query: 65 KIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFD 124 K+VIK+LKPVK+KKIKREI IL +L Sbjct: 68 KVVIKVLKPVKRKKIKREISILKNL----------------------------------- 92 Query: 125 QPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALD 184 NII + D++++P SKTP L+FE+++N+DFR LYP TD +IRFYM+ELLKALD Sbjct: 93 ---VDGPNIIAMLDVVREPQSKTPGLIFEHINNIDFRSLYPTFTDYDIRFYMYELLKALD 149 Query: 185 YCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVD 244 Y HSMGIMHRDVKPHNVMIDH K LRLIDWGLAE+YH EYNVRVASR+FKGPELLVD Sbjct: 150 YSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPELLVD 209 Query: 245 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 YR+YDYSLD+WSFG MLASM+F +EPFFHG SNTDQLV+IV+VLG+ +F+KYL KY I+L Sbjct: 210 YRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNISL 269 Query: 305 PREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 E+ D+ Y ++ W RF+N+ NK L + E +DLID LLRYDHQERLTAKEAM H +F Sbjct: 270 GEEYEDIGYYNKRQWVRFMNENNKDL-VSQEFLDLIDRLLRYDHQERLTAKEAMKHAYFD 328 Query: 365 PIREQIE 371 PIR + Sbjct: 329 PIRVAVS 335 >4MD7-E nrPDB Length = 391 Score = 341 bits (875), Expect = 2e-94, Method: Composition-based stats. Identities = 196/367 (53%), Positives = 241/367 (65%), Gaps = 41/367 (11%) Query: 1 MKCRVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKL 60 M V S ARVYT++N R EYWDYE+ V++W N DY++ K+GRGKYSEVF+ + + Sbjct: 1 MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWG-NQDDYQLVRKLGRGKYSEVFEAINI 59 Query: 61 DSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRP 120 + K + K R Sbjct: 60 TNNE--------------------------------------KVVVKILKPVKKKKIKRE 81 Query: 121 YIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELL 180 + G NII L DI+KDP+S+TPALVFE+V+N DF+ LY LTD +IRFYM+E+L Sbjct: 82 IKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEIL 141 Query: 181 KALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPE 240 KALDYCHSMGIMHRDVKPHNVMIDH+++KLRLIDWGLAEFYH EYNVRVASR+FKGPE Sbjct: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201 Query: 241 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 300 LLVDY+MYDYSLD+WS G MLASMIF++EPFFHG N DQLV+I KVLGT D Y+ KY Sbjct: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 Query: 301 EITLPREFYD-MDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMG 359 I L F D + ++ RK W RF++ N+HL + E +D +D LLRYDHQ RLTA+EAM Sbjct: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHL-VSPEALDFLDKLLRYDHQSRLTAREAME 320 Query: 360 HPWFAPI 366 HP+F + Sbjct: 321 HPYFYTV 327 >6EII-A nrPDB Length = 352 Score = 329 bits (842), Expect = 2e-90, Method: Composition-based stats. Identities = 195/364 (53%), Positives = 240/364 (65%), Gaps = 41/364 (11%) Query: 4 RVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSK 63 V S ARVYT++N R EYWDYE+ V++W N DY++ K+GRGKYSEVF+ + + + Sbjct: 27 PVPSRARVYTDVNTHRPSEYWDYESHVVEWG-NQDDYQLVRKLGRGKYSEVFEAINITNN 85 Query: 64 VKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIF 123 K + K R Sbjct: 86 E--------------------------------------KVVVKILKPVKKKKIKREIKI 107 Query: 124 DQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKAL 183 + G NII L DI+KDP+S+TPALVFE+V+N DF+ LY LTD +IRFYM+E+LKAL Sbjct: 108 LENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKAL 167 Query: 184 DYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLV 243 DYCHSMGIMHRDVKPHNVMIDH+++KLRLIDWGLAEFYH EYNVRVASR+FKGPELLV Sbjct: 168 DYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLV 227 Query: 244 DYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEIT 303 DY+MYDYSLD+WS G MLASMIF++EPFFHG N DQLV+I KVLGT D Y+ KY I Sbjct: 228 DYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIE 287 Query: 304 LPREFYD-MDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 L F D + ++ RK W RF++ N+HL + E +D +D LLRYDHQ RLTA+EAM HP+ Sbjct: 288 LDPRFNDILGRHSRKRWERFVHSENQHL-VSPEALDFLDKLLRYDHQSRLTAREAMEHPY 346 Query: 363 FAPI 366 F + Sbjct: 347 FYTV 350 >6HMD-A nrPDB Length = 365 Score = 328 bits (840), Expect = 3e-90, Method: Composition-based stats. Identities = 199/371 (53%), Positives = 237/371 (63%), Gaps = 42/371 (11%) Query: 1 MKCRV-WSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVK 59 M S ARVY +N R+ EYWDYE V W N DY++ K+GRGKYSEVF+ + Sbjct: 16 MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWG-NQDDYQLVRKLGRGKYSEVFEAIN 74 Query: 60 LDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIR 119 + + + + K R Sbjct: 75 ITNNER--------------------------------------VVVKILKPVKKKKIKR 96 Query: 120 PYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFEL 179 + G NII L D +KDP+SKTPALVFEY++N DF+ LY LTD +IRFYM+EL Sbjct: 97 EVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYEL 156 Query: 180 LKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGP 239 LKALDYCHS GIMHRDVKPHNVMIDH+ KKLRLIDWGLAEFYH EYNVRVASR+FKGP Sbjct: 157 LKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGP 216 Query: 240 ELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLK 299 ELLVDY+MYDYSLD+WS G MLASMIF+REPFFHG N DQLV+I KVLGT + YL K Sbjct: 217 ELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKK 276 Query: 300 YEITLPREFYD-MDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAM 358 Y I L F D + Q+ RK W FI+ N+HL + E +DL+D LLRYDHQ+RLTAKEAM Sbjct: 277 YHIDLDPHFNDILGQHSRKRWENFIHSENRHL-VSPEALDLLDKLLRYDHQQRLTAKEAM 335 Query: 359 GHPWFAPIREQ 369 HP+F P+ ++ Sbjct: 336 EHPYFYPVVKE 346 >2PVN-A nrPDB Length = 352 Score = 323 bits (827), Expect = 1e-88, Method: Composition-based stats. Identities = 190/367 (51%), Positives = 234/367 (63%), Gaps = 41/367 (11%) Query: 2 KCRVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLD 61 + S+ARVY ++N R +EYWDYE + W DYE+ KVGRGKYSEVF+G+ ++ Sbjct: 17 RGSHMSKARVYADVNVLRPKEYWDYEALTVQWG-EQDDYEVVRKVGRGKYSEVFEGINVN 75 Query: 62 SKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPY 121 + K + K R Sbjct: 76 NNEK--------------------------------------CIIKILKPVKKKKIKREI 97 Query: 122 IFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLK 181 Q G NI+ L DI++D SKTP+L+FEYV+N DF++LYP LTD +IR+Y++ELLK Sbjct: 98 KILQNLCGGPNIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVLYPTLTDYDIRYYIYELLK 157 Query: 182 ALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPEL 241 ALDYCHS GIMHRDVKPHNVMIDH+ +KLRLIDWGLAEFYH EYNVRVASR+FKGPEL Sbjct: 158 ALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPEL 217 Query: 242 LVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYE 301 LVD + YDYSLD+WS G M A MIF++EPFF+G N DQLVKI KVLGT YL KY Sbjct: 218 LVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYR 277 Query: 302 ITL-PREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGH 360 I L P+ + ++ RKPW +F+N N+HL + E ID +D LLRYDHQERLTA EAM H Sbjct: 278 IELDPQLEALVGRHSRKPWLKFMNADNQHL-VSPEAIDFLDKLLRYDHQERLTALEAMTH 336 Query: 361 PWFAPIR 367 P+F +R Sbjct: 337 PYFQQVR 343 >5XVU-A nrPDB Length = 332 Score = 318 bits (816), Expect = 2e-87, Method: Composition-based stats. Identities = 176/361 (48%), Positives = 226/361 (62%), Gaps = 41/361 (11%) Query: 10 RVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIK 69 + Y ++N + +EY+DY+N + W+ YEI K+GRGKYSEVF G + Sbjct: 4 KFYADVNIHKPKEYYDYDNLELQWNKP-NRYEIMKKIGRGKYSEVFNGYDTECNRPCA-- 60 Query: 70 MLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNG 129 + K R Q NG Sbjct: 61 ------------------------------------IKVLKPVKKKKIKREIKILQNLNG 84 Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSM 189 NII L DI+KDP++KTP+L+FEY++N+DF+ LYPK TD +IR+Y++++LKALDYCHS Sbjct: 85 GPNIIKLLDIVKDPVTKTPSLIFEYINNIDFKTLYPKFTDKDIRYYIYQILKALDYCHSQ 144 Query: 190 GIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYD 249 GIMHRDVKPHN+MIDH+N+++RLI WGLAEFYH EYNVRVASR++KGPELL+D ++YD Sbjct: 145 GIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRVASRYYKGPELLIDLQLYD 204 Query: 250 YSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL-PREF 308 YSLD+WS G MLA MIFK+EPFF G N DQLVKI KVLGT D YL KY I L P Sbjct: 205 YSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKYNIKLKPHYL 264 Query: 309 YDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 368 + +Y RKPW F+ N + DE+IDLID +L YDH +R+ KEAM HP+F +RE Sbjct: 265 NILGEYERKPWSHFLTQSNIDI-AKDEVIDLIDKMLIYDHAKRIAPKEAMEHPYFREVRE 323 Query: 369 Q 369 + Sbjct: 324 E 324 >3OHT-A nrPDB Length = 389 Score = 280 bits (717), Expect = 5e-76, Method: Composition-based stats. Identities = 92/377 (24%), Positives = 170/377 (45%), Gaps = 63/377 (16%) Query: 4 RVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSK 63 + S A +T +K+R Y N I W + Y+ + VG G Y V + S Sbjct: 19 KAGSAAAPFTMSHKERPTFYRQELNKTI-WEVP-ERYQTLSPVGSGAYGSVCSSYDVKSG 76 Query: 64 VKIVIKMLKP-----VKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFI 118 +KI +K L + K+ RE+++L + Sbjct: 77 LKIAVKKLSRPFQSIIHAKRTYRELRLLKHMK---------------------------- 108 Query: 119 RPYIFDQPHNGHANIIHLFDIIKDPIS----KTPALVFEYVDNVDF--RILYPKLTDLEI 172 H N+I L D+ S LV + D + KLTD + Sbjct: 109 -----------HENVIGLLDVFTPATSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHV 156 Query: 173 RFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVA 232 +F ++++L+ L Y HS I+HRD+KP N+ ++ ++ +L+++D+GLA H + E VA Sbjct: 157 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR--HTDDEMTGYVA 213 Query: 233 SRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSD 292 +R+++ PE+++++ Y+ ++D+WS G ++A ++ R F GT + +QL +I+++ GT Sbjct: 214 TRWYRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRT-LFPGTDHINQLQQIMRLTGTPP 272 Query: 293 FEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERL 352 + Q ++ N + + N +DL++ +L D +R+ Sbjct: 273 ASVISRMPSHEARNYINSLPQMPKR------NFADVFIGANPLAVDLLEKMLVLDTDKRI 326 Query: 353 TAKEAMGHPWFAPIREQ 369 TA EA+ HP+F+ + Sbjct: 327 TASEALAHPYFSQYHDP 343 >4EWQ-A nrPDB Length = 383 Score = 274 bits (701), Expect = 3e-74, Method: Composition-based stats. Identities = 88/368 (23%), Positives = 167/368 (45%), Gaps = 63/368 (17%) Query: 13 TNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK 72 +N +++R Y N I W + Y+ + VG G Y V + +++ +K L Sbjct: 22 SNASQERPTFYRQELNKTI-WEVP-ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLS 79 Query: 73 P-----VKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPH 127 + K+ RE+++L + Sbjct: 80 RPFQSIIHAKRTYRELRLLKHMK------------------------------------- 102 Query: 128 NGHANIIHLFDIIKDPIS----KTPALVFEYVDNVDF--RILYPKLTDLEIRFYMFELLK 181 H N+I L D+ S LV + D + KLTD ++F ++++L+ Sbjct: 103 --HENVIGLLDVFTPARSLEEFNDVYLVTHLM-GADLNNIVKCQKLTDDHVQFLIYQILR 159 Query: 182 ALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPEL 241 L Y HS I+HRD+KP N+ ++ ++ +L+++D+GLA H + E VA+R+++ PE+ Sbjct: 160 GLKYIHSADIIHRDLKPSNLAVN-EDCELKILDFGLAR--HTDDEMTGYVATRWYRAPEI 216 Query: 242 LVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYE 301 ++++ Y+ ++D+WS G ++A ++ R F GT + DQL I++++GT E Sbjct: 217 MLNWMHYNQTVDIWSVGCIMAELLTGRT-LFPGTDHIDQLKLILRLVGTPGAELLKKISS 275 Query: 302 ITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHP 361 + + Q + +N N + N +DL++ +L D +R+TA +A+ H Sbjct: 276 ESARNYIQSLTQMPK------MNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHA 329 Query: 362 WFAPIREQ 369 +FA + Sbjct: 330 YFAQYHDP 337 >3NIZ-A nrPDB Length = 311 Score = 268 bits (685), Expect = 3e-72, Method: Composition-based stats. Identities = 92/343 (26%), Positives = 167/343 (48%), Gaps = 60/343 (17%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK-----IKREIKILTDLSN 91 + Y+ KVG G Y V++ ++ + +K ++ + + REI +L +L Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKDSQGRI-VALKRIRLDAEDEGIPSTAIREISLLKELH- 77 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H NI+ L D+I + LV Sbjct: 78 --------------------------------------HPNIVSLIDVIHS--ERCLTLV 97 Query: 152 FEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK 208 FE+++ ++L L D +I+ Y+++LL+ + +CH I+HRD+KP N++I+ + Sbjct: 98 FEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRGVAHCHQHRILHRDLKPQNLLINS-DG 156 Query: 209 KLRLIDWGLAEFYHVNME-YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 L+L D+GLA + + + Y V + +++ P++L+ + Y S+D+WS G + A MI Sbjct: 157 ALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSKKYSTSVDIWSIGCIFAEMITG 216 Query: 268 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGN 327 + P F G ++ DQL KI +LGT + ++ E+ L ++ + +KPW I Sbjct: 217 K-PLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQR-TFQVFEKKPWSSIIPGFC 274 Query: 328 KHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQI 370 + E IDL+ N+L +D +R++A++AM HP+F + QI Sbjct: 275 Q------EGIDLLSNMLCFDPNKRISARDAMNHPYFKDLDPQI 311 >4MYG-A nrPDB Length = 372 Score = 267 bits (682), Expect = 6e-72, Method: Composition-based stats. Identities = 87/358 (24%), Positives = 157/358 (43%), Gaps = 49/358 (13%) Query: 19 RTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK 78 R + ++ + W K Y VG G Y V + S K+ IK L Sbjct: 25 RKKGFYKQDVNKTAWELP-KTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRP---- 79 Query: 79 IKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFD 138 Q E K + H H N+I L D Sbjct: 80 ------------------------------FQSEIFAKRAYRELLLLKHMQHENVIGLLD 109 Query: 139 IIKDPIS----KTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHR 194 + S LV ++ +I+ + ++ +I++ ++++LK L Y HS G++HR Sbjct: 110 VFTPASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYIHSAGVVHR 169 Query: 195 DVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDL 254 D+KP N+ ++ ++ +L+++D+GLA H + E V +R+++ PE+++ + Y+ ++D+ Sbjct: 170 DLKPGNLAVN-EDCELKILDFGLAR--HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDI 226 Query: 255 WSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQY 314 WS G ++A M+ + F G DQL +I+KV G E + + Q Sbjct: 227 WSVGCIMAEMLTGKT-LFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQT 285 Query: 315 IRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK 372 RK + + + + DL++ +L D +RLTA +A+ HP+F P R+ E+ Sbjct: 286 PRKDFTQLFP------RASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEE 337 >2BPM-A nrPDB Length = 309 Score = 266 bits (681), Expect = 8e-72, Method: Composition-based stats. Identities = 81/347 (23%), Positives = 160/347 (46%), Gaps = 63/347 (18%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK-----IKREIKILTDL 89 + ++++ K+G G Y V++ + + +K ++ + + REI +L +L Sbjct: 4 VDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL 63 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 + H NI+ L D+I Sbjct: 64 N---------------------------------------HPNIVKLLDVIH--TENKLY 82 Query: 150 LVFEYVDNVDFRILYP-----KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID 204 LVFE++ + D + + I+ Y+F+LL+ L +CHS ++HRD+KP N++I+ Sbjct: 83 LVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLIN 141 Query: 205 HKNKKLRLIDWGLAEFYHVNM-EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLAS 263 + ++L D+GLA + V + Y V + +++ PE+L+ + Y ++D+WS G + A Sbjct: 142 TEGA-IKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAE 200 Query: 264 MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFI 323 M+ +R F G S DQL +I + LGT D + ++P ++ R+ + + + Sbjct: 201 MVTRRA-LFPGDSEIDQLFRIFRTLGTPDEVVW--PGVTSMPDYKPSFPKWARQDFSKVV 257 Query: 324 NDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQI 370 +++ L+ +L YD +R++AK A+ HP+F + + + Sbjct: 258 PP------LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 298 >5Z33-A nrPDB Length = 425 Score = 266 bits (679), Expect = 1e-71, Method: Composition-based stats. Identities = 82/340 (24%), Positives = 155/340 (45%), Gaps = 60/340 (17%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML-----KPVKKKKIKREIKILTDLSNE 92 + Y + ++G+G Y V V + + IK + K + K+ REIK+L Sbjct: 31 ERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQH---- 86 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDI-IKDPISKTPALV 151 GH NI L+D+ I P + + Sbjct: 87 ----------------------------------FRGHRNITCLYDMDIPRPDNFNETYL 112 Query: 152 FEYVDNVDFRILY---PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK 208 +E + D + LTD + +++++L L Y HS ++HRD+KP N++++ + Sbjct: 113 YEELMECDLAAIIRSGQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNA-DC 171 Query: 209 KLRLIDWGLAEFYHVNME-----YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLAS 263 +L++ D+GLA + V+ E VA+R+++ PE+++ ++ Y ++D+WS G +LA Sbjct: 172 ELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAE 231 Query: 264 MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFI 323 ++ PFF G DQL +I+ +LGT + E ++ +KP+ Sbjct: 232 LL-GGRPFFKGRDYVDQLNQILHILGTPNEETLSRIGSPRAQEYVRNLPFMAKKPFPTLF 290 Query: 324 NDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + N + +DL+D +L +D R++ ++A+ HP+ Sbjct: 291 PNA------NPDALDLLDRMLAFDPSSRISVEQALEHPYL 324 >5NGU-A nrPDB Length = 381 Score = 260 bits (665), Expect = 5e-70, Method: Composition-based stats. Identities = 81/338 (23%), Positives = 155/338 (45%), Gaps = 59/338 (17%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKK----KIKREIKILTDLSNEKVP 95 Y + +G G Y V +KV++ IK + P + + + REIKIL Sbjct: 44 YTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLR------- 96 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI---SKTPALVF 152 H NII + DII+ P K +V Sbjct: 97 --------------------------------FRHENIIGINDIIRAPTIEQMKDVYIVQ 124 Query: 153 EYVDNVDFRILY-PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 + ++ +++L L++ I ++++++L+ L Y HS ++HRD+KP N++++ L+ Sbjct: 125 DLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNT-TCDLK 183 Query: 212 LIDWGLAEFYHVNMEYNVR----VASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 + D+GLA + ++ VA+R+++ PE++++ + Y S+D+WS G +LA M+ Sbjct: 184 ICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN 243 Query: 268 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGN 327 R P F G DQL I+ +LG+ E + + + PW+R + Sbjct: 244 R-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNA- 301 Query: 328 KHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 + + +DL+D +L ++ +R+ ++A+ HP+ Sbjct: 302 -----DSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ 334 >6GU6-A nrPDB Length = 302 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 84/349 (24%), Positives = 160/349 (45%), Gaps = 64/349 (18%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK-----IKREIKILTDLS 90 + +DY K+G G Y V++G + + +K ++ +++ REI +L +L Sbjct: 5 SMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR 64 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 H NI+ L D++ L Sbjct: 65 ---------------------------------------HPNIVSLQDVLMQ--DSRLYL 83 Query: 151 VFEYVDNVDFRILYPKLTDLE------IRFYMFELLKALDYCHSMGIMHRDVKPHNVMID 204 +FE++ D + + + ++ Y++++L+ + +CHS ++HRD+KP N++ID Sbjct: 84 IFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLID 142 Query: 205 HKNKKLRLIDWGLAEFYHVNME-YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLAS 263 K ++L D+GLA + + + Y V + +++ PE+L+ Y +D+WS GT+ A Sbjct: 143 DKGT-IKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAE 201 Query: 264 MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFI 323 + ++P FHG S DQL +I + LGT + E + P D P + Sbjct: 202 LAT-KKPLFHGDSEIDQLFRIFRALGTPNNEVW--------PEVESLQDYKNTFPKWKPG 252 Query: 324 NDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK 372 + + + ++ +DL+ +L YD +R++ K A+ HP+F + QI+K Sbjct: 253 SLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKK 301 >4QTB-A nrPDB Length = 380 Score = 258 bits (660), Expect = 2e-69, Method: Composition-based stats. Identities = 76/338 (22%), Positives = 149/338 (44%), Gaps = 59/338 (17%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKK----KIKREIKILTDLSNEKVP 95 Y +G G Y V K ++ IK + P + + + REI+IL Sbjct: 43 YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLR------- 95 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI---SKTPALVF 152 H N+I + DI++ + +V Sbjct: 96 --------------------------------FRHENVIGIRDILRASTLEAMRDVYIVQ 123 Query: 153 EYVDNVDFRILY-PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 + ++ +++L +L++ I ++++++L+ L Y HS ++HRD+KP N++I+ L+ Sbjct: 124 DLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINT-TCDLK 182 Query: 212 LIDWGLAEFYHVNMEYNVR----VASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 + D+GLA ++ VA+R+++ PE++++ + Y S+D+WS G +LA M+ Sbjct: 183 ICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN 242 Query: 268 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGN 327 R P F G DQL I+ +LG+ E + + + W + Sbjct: 243 R-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFP--- 298 Query: 328 KHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 + + +DL+D +L ++ +R+T +EA+ HP+ Sbjct: 299 ---KSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQ 333 >3OZ6-A nrPDB Length = 388 Score = 258 bits (658), Expect = 3e-69, Method: Composition-based stats. Identities = 80/373 (21%), Positives = 166/373 (44%), Gaps = 78/373 (20%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML-----KPVKKKKIKREIKILTDLSNE 92 + YE+ K+G+G Y V++ + + + +K + ++ REI ILT+LS Sbjct: 9 RKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELS-- 66 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF 152 GH NI++L ++++ + LVF Sbjct: 67 ------------------------------------GHENIVNLLNVLRADNDRDVYLVF 90 Query: 153 EYVDNVDFRILYPKLTDL-EIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 +Y++ ++ + + ++ +++L+K + Y HS G++HRD+KP N++++ + ++ Sbjct: 91 DYMETDLHAVIRANILEPVHKQYVVYQLIKVIKYLHSGGLLHRDMKPSNILLNAE-CHVK 149 Query: 212 LIDWGLAEFY----------------------HVNMEYNVRVASRFFKGPELLVDYRMYD 249 + D+GL+ + VA+R+++ PE+L+ Y Sbjct: 150 VADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQPILTDYVATRWYRAPEILLGSTKYT 209 Query: 250 YSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKY------LLKYEIT 303 +D+WS G +L ++ + P F G+S +QL +I+ V+ E K I Sbjct: 210 KGIDMWSLGCILGEILCGK-PIFPGSSTMNQLERIIGVIDFPSNEDVESIQSPFAKTMIE 268 Query: 304 LPREFYDMDQYIRKP----WHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMG 359 +E ++ Q ++ W + N N+E +DL+D LL+++ +R++A +A+ Sbjct: 269 SLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCNEEALDLLDKLLQFNPNKRISANDALK 328 Query: 360 HPWFAPIREQIEK 372 HP+ + E+ Sbjct: 329 HPFVSIFHNPNEE 341 >4KRC-A nrPDB Length = 317 Score = 257 bits (656), Expect = 6e-69, Method: Composition-based stats. Identities = 86/343 (25%), Positives = 165/343 (48%), Gaps = 59/343 (17%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKK----KIKREIKILTDLSN 91 ++ ++ K+G G Y+ V++G+ + V + +K +K ++ REI ++ +L Sbjct: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELK- 61 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H NI+ L+D+I LV Sbjct: 62 --------------------------------------HENIVRLYDVIH--TENKLTLV 81 Query: 152 FEYVDNVDFRILYPK--------LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI 203 FE++DN + + + L ++++ ++LL+ L +CH I+HRD+KP N++I Sbjct: 82 FEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLI 141 Query: 204 DHKNKKLRLIDWGLAEFYHVN-MEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLA 262 + K +L+L D+GLA + + ++ V + +++ P++L+ R Y S+D+WS G +LA Sbjct: 142 N-KRGQLKLGDFGLARAFGIPVNTFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILA 200 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 MI + P F GT++ +QL I ++GT + + LP+ ++ Q + + Sbjct: 201 EMITGK-PLFPGTNDEEQLKLIFDIMGTPNESLW--PSVTKLPKYNPNIQQRPPRDLRQV 257 Query: 323 INDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 + K + ++D + LL+ + RL+AK+A+ HPWFA Sbjct: 258 LQPHTKEP-LDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAE 299 >4AU8-A nrPDB Length = 296 Score = 257 bits (656), Expect = 6e-69, Method: Composition-based stats. Identities = 88/342 (25%), Positives = 155/342 (45%), Gaps = 59/342 (17%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK-----IKREIKILTD 88 + ++ YE K+G G Y VF+ ++ + +K ++ + REI +L + Sbjct: 2 AMGSQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKE 61 Query: 89 LSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTP 148 L H NI+ L D++ K Sbjct: 62 LK---------------------------------------HKNIVRLHDVLHS--DKKL 80 Query: 149 ALVFEYVDNVD---FRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 LVFE+ D F L ++ ++F+LLK L +CHS ++HRD+KP N++I+ Sbjct: 81 TLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSRNVLHRDLKPQNLLIN- 139 Query: 206 KNKKLRLIDWGLAEFYHVNME-YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASM 264 +N +L+L D+GLA + + + Y+ V + +++ P++L ++Y S+D+WS G + A + Sbjct: 140 RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAEL 199 Query: 265 IFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIN 324 P F G DQL +I ++LGT E++ + D Y P + Sbjct: 200 ANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTK------LPDYKPYPMYPATT--S 251 Query: 325 DGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPI 366 N N DL+ NLL+ + +R++A+EA+ HP+F+ Sbjct: 252 LVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDF 293 >1CM8-A nrPDB Length = 367 Score = 257 bits (656), Expect = 6e-69, Method: Composition-based stats. Identities = 84/357 (23%), Positives = 155/357 (43%), Gaps = 51/357 (14%) Query: 17 KQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK 76 R+ Y W Y VG G Y V V + K+ IK L Sbjct: 6 PARSGFYRQEVTKT-AWEVRAV-YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKL----- 58 Query: 77 KKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHL 136 Y Q E K + H H N+I L Sbjct: 59 -----------------------------YRPFQSELFAKRAYRELRLLKHMRHENVIGL 89 Query: 137 FDIIKDPIS----KTPALVFEYVDNVDFRIL-YPKLTDLEIRFYMFELLKALDYCHSMGI 191 D+ + LV ++ +++ + KL + I+F ++++LK L Y H+ GI Sbjct: 90 LDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDRIQFLVYQMLKGLRYIHAAGI 149 Query: 192 MHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYS 251 +HRD+KP N+ ++ ++ +L+++D+GLA + E V +R+++ PE+++++ Y + Sbjct: 150 IHRDLKPGNLAVN-EDCELKILDFGLAR--QADSEMTGYVVTRWYRAPEVILNWMRYTQT 206 Query: 252 LDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDM 311 +D+WS G ++A MI + F G+ + DQL +I+KV GT E + Sbjct: 207 VDIWSVGCIMAEMITGKT-LFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGL 265 Query: 312 DQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 368 + +K + + + + ++L++ +L D ++R+TA EA+ HP+F + + Sbjct: 266 PELEKKDFASILTNA------SPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHD 316 >2F9G-A nrPDB Length = 353 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 85/353 (24%), Positives = 154/353 (43%), Gaps = 67/353 (18%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKK----KIKREIKILTDLSNE 92 + D+++++ +G G Y V + + IK ++P K + REIKIL Sbjct: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILK----- 64 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKT---PA 149 H H NII +F+I + + Sbjct: 65 ----------------------------------HFKHENIITIFNIQRPDSFENFNEVY 90 Query: 150 LVFEYVDNVDFRILYPK-LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK 208 ++ E + R++ + L+D I++++++ L+A+ H ++HRD+KP N++I+ N Sbjct: 91 IIQELMQTDLHRVISTQMLSDDHIQYFIYQTLRAVKVLHGSNVIHRDLKPSNLLINS-NC 149 Query: 209 KLRLIDWGLAEFYHVNME-----------YNVRVASRFFKGPELLVDYRMYDYSLDLWSF 257 L++ D+GLA + VA+R+++ PE+++ Y ++D+WS Sbjct: 150 DLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSC 209 Query: 258 GTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREF-YDMDQYIR 316 G +LA +F R P F G QL+ I ++GT + L E RE+ + Y Sbjct: 210 GCILAE-LFLRRPIFPGRDYRHQLLLIFGIIGTPHSDNDLRCIESPRAREYIKSLPMYPA 268 Query: 317 KPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 P + N + IDL+ +L +D +R+TAKEA+ HP+ + Sbjct: 269 APLEKMFP------RVNPKGIDLLQRMLVFDPAKRITAKEALEHPYLQTYHDP 315 >4MVF-A nrPDB Length = 506 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 77/365 (21%), Positives = 138/365 (37%), Gaps = 85/365 (23%) Query: 15 INKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPV 74 I+++ T + Y I+ K+G+G Y V++G+ + IK K Sbjct: 34 ISREGTTTLERKNLILCHSGKLEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKD 93 Query: 75 KKK---KIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHA 131 + K + +EI+I+ L H Sbjct: 94 RLKNINRFFQEIEIMKKLD---------------------------------------HP 114 Query: 132 NIIHLFDIIKDPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYCHS 188 NI+ L++ ++ L+ E D I T+ M ++ A+ Y HS Sbjct: 115 NIVKLYETYEN--DNYIYLIMELCSGRELFDSIIENGSFTEKNAATIMKQIFSAIFYLHS 172 Query: 189 MGIMHRDVKPHNVMIDHKNKK--LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYR 246 + I+HRD+KP N + +NK L++ID+GL++ + + ++ P++L Sbjct: 173 LNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAPQVLDG-- 230 Query: 247 MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPR 306 YD D+WS G ++ +++ PF+ G ++ + L K+ K Sbjct: 231 KYDKKCDIWSSGVIMYTLLCGYPPFY-GDTDNEVLKKVKKG------------------- 270 Query: 307 EFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPI 366 F N S + + +LI LL Y+ ER T +EA+ HPW + Sbjct: 271 --------------EFCFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALNHPWITQM 316 Query: 367 REQIE 371 + E Sbjct: 317 TKSHE 321 >6DTL-A nrPDB Length = 364 Score = 254 bits (649), Expect = 4e-68, Method: Composition-based stats. Identities = 76/333 (22%), Positives = 151/333 (45%), Gaps = 58/333 (17%) Query: 46 VGRGKYSEVFQGVKLDSKVKIVIKML-----KPVKKKKIKREIKILTDLSNEKVPPTTLP 100 +G+G Y V + ++ + IK + + K+ REIK+L Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLR------------- 84 Query: 101 FQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISK---TPALVFEYVDN 157 H H NI+ + DII P+ + +E +D Sbjct: 85 --------------------------HMDHENIVAIRDIIPPPLRNAFNDVYIAYELMDT 118 Query: 158 VDFRILY--PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDW 215 +I+ L++ +++++++L+ L Y HS ++HRD+KP N++++ N L++ D+ Sbjct: 119 DLHQIIRSNQALSEEHCQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNA-NCDLKICDF 177 Query: 216 GLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGT 275 GLA + V +R+++ PELL++ Y ++D+WS G + ++ R+P F G Sbjct: 178 GLARVTSESDFMTEYVVTRWYRAPELLLNSSDYTAAIDVWSVGCIFMELM-DRKPLFPGR 236 Query: 276 SNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDE 335 + QL +++++GT + L R + Y R+ + +K + + Sbjct: 237 DHVHQLRLLMELIGTPSE-EELEFLNENAKRYIRQLPPYPRQ------SITDKFPTVHPL 289 Query: 336 IIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 368 IDLI+ +L +D + R+T +A+ HP+ + + Sbjct: 290 AIDLIEKMLTFDPRRRITVLDALAHPYLNSLHD 322 >1V0B-A nrPDB Length = 288 Score = 253 bits (646), Expect = 8e-68, Method: Composition-based stats. Identities = 84/338 (24%), Positives = 156/338 (46%), Gaps = 61/338 (18%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK-----IKREIKILTDLSN 91 + Y K+G G Y V++ + +K ++ K+ + REI IL +L Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQN-NYGETFALKKIRLEKEDEGIPSTTIREISILKELK- 58 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H+NI+ L+D+I K LV Sbjct: 59 --------------------------------------HSNIVKLYDVIH--TKKRLVLV 78 Query: 152 FEYVDNV---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK 208 FE++D + L + + ++ +LL + YCH ++HRD+KP N++I+ + Sbjct: 79 FEHLDQDLKKLLDVCEGGLESVTAKSFLLQLLNGIAYCHDRRVLHRDLKPQNLLINREG- 137 Query: 209 KLRLIDWGLAEFYHVNM-EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 +L++ D+GLA + + + +Y V + +++ P++L+ + Y ++D+WS G + A M+ Sbjct: 138 ELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKKYSTTIDIWSVGCIFAEMVNG 197 Query: 268 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGN 327 P F G S DQL++I ++LGT + + + LP+ + Y PW F+ Sbjct: 198 A-PLFPGVSEADQLMRIFRILGTPNSKNW--PNVTELPKYDPNFTVYEPLPWESFLK--- 251 Query: 328 KHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 ++ IDL+ +L+ D +R+TAK+A+ H +F Sbjct: 252 ---GLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >1G3N-A nrPDB Length = 326 Score = 251 bits (642), Expect = 2e-67, Method: Composition-based stats. Identities = 89/345 (25%), Positives = 159/345 (46%), Gaps = 64/345 (18%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVK-IVIKMLKPVKKKK-----IKREIKILTDLSN 91 + YE ++G G Y +VF+ L + + + +K ++ ++ RE+ +L L Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII---KDPISKTP 148 H N++ LFD+ + Sbjct: 71 ------------------------------------FEHPNVVRLFDVCTVSRTDRETKL 94 Query: 149 ALVFEYVDNVDFRILYPKLTD-----LEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI 203 LVFE+VD D K+ + I+ MF+LL+ LD+ HS ++HRD+KP N+++ Sbjct: 95 TLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILV 153 Query: 204 DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLAS 263 + +++L D+GLA Y M V + +++ PE+L+ Y +DLWS G + A Sbjct: 154 TS-SGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAE 211 Query: 264 MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFI 323 M F+R+P F G+S+ DQL KI+ V+G E + ++ LPR+ + +P +F+ Sbjct: 212 M-FRRKPLFRGSSDVDQLGKILDVIGLPGEEDW--PRDVALPRQAFHSKS--AQPIEKFV 266 Query: 324 NDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 368 D ++ DL+ L ++ +R++A A+ HP+F + Sbjct: 267 TD------IDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 >3HZT-A nrPDB Length = 467 Score = 250 bits (637), Expect = 9e-67, Method: Composition-based stats. Identities = 71/344 (20%), Positives = 134/344 (38%), Gaps = 88/344 (25%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKK------KIKREIKILTDLS 90 + Y+ K+G G Y EV + + IK++K + E+ +L L Sbjct: 3 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLD 62 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 H NI+ L++ +D + L Sbjct: 63 ---------------------------------------HPNIMKLYEFFED--KRNYYL 81 Query: 151 VFEYVDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN 207 V E + IL K ++++ M ++L Y H I+HRD+KP N++++ K+ Sbjct: 82 VMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKHNIVHRDLKPENLLLESKS 141 Query: 208 KK--LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 + ++++D+GL+ + V + R+ + ++ PE+L + YD D+WS G +L ++ Sbjct: 142 RDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL--RKKYDEKCDVWSCGVILYILL 199 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 PF G ++ + L ++ K +F D Sbjct: 200 CGYPPF-GGQTDQEILKRVEKG---------------------------------KFSFD 225 Query: 326 GNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 +DE L+ +L Y+ +R++A+EA+ HPW Q Sbjct: 226 PPDWTQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWIVKFCSQ 269 >3EB0-A nrPDB Length = 383 Score = 250 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 87/347 (25%), Positives = 162/347 (46%), Gaps = 23/347 (6%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 93 T++K Y + +G G + V + ++S + +K + + K RE+ I+ L + Sbjct: 3 ETSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYK-NRELDIMKVLDHVN 61 Query: 94 VPPTTLPFQKDQYYTNQKEDV--LKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 + F + + +N H ++I + +K ++ Sbjct: 62 IIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVI-----VNPSQNKYLNVI 116 Query: 152 FEYVDNVDFRILYPKLTDLE------IRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 EYV + ++L + I Y+++L +A+ + HS+GI HRD+KP N++++ Sbjct: 117 MEYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNS 176 Query: 206 KNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 K+ L+L D+G A+ + + SRF++ PEL++ Y S+DLWS G + +I Sbjct: 177 KDNTLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELI 236 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 + P F G ++ DQLV+I++++GT E+ + F + K W + + + Sbjct: 237 LGK-PLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLK---AKDWRKILPE 292 Query: 326 GNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK 372 G L IDL++ +LRY+ R+ EAM HP+F +R E Sbjct: 293 GTPSL-----AIDLLEQILRYEPDLRINPYEAMAHPFFDHLRNSYES 334 >1UA2-A nrPDB Length = 346 Score = 250 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 93/347 (26%), Positives = 162/347 (46%), Gaps = 64/347 (18%) Query: 30 VIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIK--------R 81 +D + K YE + +G G+++ V++ ++ + IK +K + + K R Sbjct: 2 ALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALR 61 Query: 82 EIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIK 141 EIK+L +LS H NII L D Sbjct: 62 EIKLLQELS---------------------------------------HPNIIGLLDAFG 82 Query: 142 DPISKTPALVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKP 198 + +LVF++++ I+ LT I+ YM L+ L+Y H I+HRD+KP Sbjct: 83 HKSN--ISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKP 140 Query: 199 HNVMIDHKNKKLRLIDWGLAEFY-HVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSF 257 +N+++D +N L+L D+GLA+ + N Y +V +R+++ PELL RMY +D+W+ Sbjct: 141 NNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAV 199 Query: 258 GTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRK 317 G +LA ++ R PF G S+ DQL +I + LGT E++ + + Y+ Sbjct: 200 GCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQW---------PDMCSLPDYVTF 249 Query: 318 PWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 I + + D+++DLI L ++ R+TA +A+ +F+ Sbjct: 250 KSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFS 296 >3DXN-A nrPDB Length = 287 Score = 248 bits (632), Expect = 3e-66, Method: Composition-based stats. Identities = 71/344 (20%), Positives = 134/344 (38%), Gaps = 88/344 (25%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKK------KIKREIKILTDLS 90 + Y+ K+G G Y EV + + IK++K + E+ +L L Sbjct: 20 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLD 79 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 H NI+ L++ +D + L Sbjct: 80 ---------------------------------------HPNIMKLYEFFED--KRNYYL 98 Query: 151 VFEYVDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN 207 V E + IL K ++++ M ++L Y H I+HRD+KP N++++ K+ Sbjct: 99 VMEVYRGGELFDEIILRQKFSEVDAAVIMKQVLSGTTYLHKHNIVHRDLKPENLLLESKS 158 Query: 208 KK--LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 + ++++D+GL+ + V + R+ + ++ PE+L + YD D+WS G +L ++ Sbjct: 159 RDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAPEVL--RKKYDEKCDVWSCGVILYILL 216 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 PF G ++ + L ++ K +F D Sbjct: 217 CGYPPF-GGQTDQEILKRVEKG---------------------------------KFSFD 242 Query: 326 GNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 +DE L+ +L Y+ +R++A+EA+ HPW Q Sbjct: 243 PPDWTQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWIVKFCSQ 286 >5AIR-A nrPDB Length = 430 Score = 248 bits (632), Expect = 4e-66, Method: Composition-based stats. Identities = 92/340 (27%), Positives = 138/340 (40%), Gaps = 59/340 (17%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 Y +G G + V+Q DS + IK + K+ K RE++I+ L Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK-NRELQIMRKLD--------- 115 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISK----TPALVFEYV 155 H NI+ L K LV +YV Sbjct: 116 ------------------------------HCNIVRLRYFFYSSGEKKDEVYLNLVLDYV 145 Query: 156 DNVDFRILY------PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 +R+ L + ++ YM++L ++L Y HS GI HRD+KP N+++D Sbjct: 146 PETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAV 205 Query: 210 LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 L+L D+G A+ + SR+++ PEL+ Y S+D+WS G +LA ++ + Sbjct: 206 LKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQ- 264 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 P F G S DQLV+I+KVLGT E+ + Q PW + Sbjct: 265 PIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNY---TEFKFPQIKAHPWTKVFRPRTP- 320 Query: 330 LSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 E I L LL Y RLT EA H +F +R+ Sbjct: 321 ----PEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDP 356 >4IC8-A nrPDB Length = 442 Score = 248 bits (632), Expect = 4e-66, Method: Composition-based stats. Identities = 79/348 (22%), Positives = 151/348 (43%), Gaps = 63/348 (18%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP-----VKKKKIKREIKILTDLSNE 92 +YEI +G G Y V + + ++ IK + K+ RE+KIL Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILK----- 109 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI----SKTP 148 H H NII + DI++ + K+ Sbjct: 110 ----------------------------------HFKHDNIIAIKDILRPTVPYGEFKSV 135 Query: 149 ALVFEYVDNVDFRILY--PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK 206 +V + +++ +I++ LT +R+++++LL+ L Y HS ++HRD+KP N++++ + Sbjct: 136 YVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVN-E 194 Query: 207 NKKLRLIDWGLAEFYHVNME-----YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTML 261 N +L++ D+G+A + VA+R+++ PEL++ Y ++DLWS G + Sbjct: 195 NCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIF 254 Query: 262 ASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 M+ +R+ F G + QL I+ VLGT + + PW Sbjct: 255 GEMLARRQ-LFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWET 313 Query: 322 FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 ++ + + L+ +LR++ R++A A+ HP+ A + Sbjct: 314 VYPGADR------QALSLLGRMLRFEPSARISAAAALRHPFLAKYHDP 355 >3NCG-A nrPDB Length = 486 Score = 247 bits (630), Expect = 6e-66, Method: Composition-based stats. Identities = 68/346 (19%), Positives = 134/346 (38%), Gaps = 87/346 (25%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML-----KPVKKKKIKREIKILTD 88 T + Y I +G+G + EV + ++ + +K++ K I RE+++L Sbjct: 18 GTFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKK 77 Query: 89 LSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTP 148 L H NI+ LF+I++D S Sbjct: 78 LD---------------------------------------HPNIMKLFEILEDSSSF-- 96 Query: 149 ALVFEYVDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID- 204 +V E + I + ++ + + ++ + Y H I+HRD+KP N++++ Sbjct: 97 YIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLES 156 Query: 205 -HKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLAS 263 K+ +++ID+GL+ + N + R+ + ++ PE+L YD D+WS G +L Sbjct: 157 KEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG--TYDEKCDVWSAGVILYI 214 Query: 264 MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFI 323 ++ PF+ G + D L ++ D ++ Sbjct: 215 LLSGTPPFY-GKNEYDILKRVETGKYAFDLPQWR-------------------------- 247 Query: 324 NDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 + +D+ DLI +L + R+TA + + HPW + Sbjct: 248 -------TISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSE 286 >3GC9-A nrPDB Length = 370 Score = 247 bits (630), Expect = 7e-66, Method: Composition-based stats. Identities = 84/365 (23%), Positives = 155/365 (42%), Gaps = 63/365 (17%) Query: 19 RTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP----- 73 R Y N + W + + VG G Y V + K+ +K L Sbjct: 11 RAGFYRQELNKTV-WEVPQR-LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSL 68 Query: 74 VKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANI 133 + ++ RE+++L L +E N+ Sbjct: 69 IHARRTYRELRLLKHLKHE---------------------------------------NV 89 Query: 134 IHLFDIIKDPIS----KTPALVFEYVDNVDF--RILYPKLTDLEIRFYMFELLKALDYCH 187 I L D+ S LV + D + L+D ++F +++LL+ L Y H Sbjct: 90 IGLLDVFTPATSIEDFSEVYLVTTLM-GADLNNIVKSQALSDEHVQFLVYQLLRGLKYIH 148 Query: 188 SMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRM 247 S GI+HRD+KP NV ++ ++ +LR++D+GLA + E VA+R+++ PE+++++ Sbjct: 149 SAGIIHRDLKPSNVAVN-EDSELRILDFGLAR--QADEEMTGYVATRWYRAPEIMLNWMH 205 Query: 248 YDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPRE 307 Y+ ++D+WS G ++A ++ + F G+ DQL +I++V+GT E Sbjct: 206 YNQTVDIWSVGCIMAELLQGKA-LFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTY 264 Query: 308 FYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIR 367 + +K N IDL+ +L D +R++A EA+ H +F+ Sbjct: 265 IQSLPPMPQKDLSSI------FRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYH 318 Query: 368 EQIEK 372 + ++ Sbjct: 319 DPEDE 323 >3DFA-A nrPDB Length = 286 Score = 245 bits (624), Expect = 3e-65, Method: Composition-based stats. Identities = 68/346 (19%), Positives = 134/346 (38%), Gaps = 87/346 (25%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML-----KPVKKKKIKREIKILTD 88 T + Y I +G+G + EV + ++ + +K++ K I RE+++L Sbjct: 18 GTFAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKK 77 Query: 89 LSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTP 148 L H NI+ LF+I++D S Sbjct: 78 LD---------------------------------------HPNIMKLFEILEDSSSF-- 96 Query: 149 ALVFEYVDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID- 204 +V E + I + ++ + + ++ + Y H I+HRD+KP N++++ Sbjct: 97 YIVGELYTGGELFDEIIKRKRFSEHDAARIIKQVFSGITYMHKHNIVHRDLKPENILLES 156 Query: 205 -HKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLAS 263 K+ +++ID+GL+ + N + R+ + ++ PE+L YD D+WS G +L Sbjct: 157 KEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVLRG--TYDEKCDVWSAGVILYI 214 Query: 264 MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFI 323 ++ PF+ G + D L ++ D ++ Sbjct: 215 LLSGTPPFY-GKNEYDILKRVETGKYAFDLPQWR-------------------------- 247 Query: 324 NDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 + +D+ DLI +L + R+TA + + HPW + Sbjct: 248 -------TISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKYSSE 286 >3LIJ-A nrPDB Length = 494 Score = 244 bits (623), Expect = 4e-65, Method: Composition-based stats. Identities = 71/346 (20%), Positives = 139/346 (40%), Gaps = 87/346 (25%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKK-----KIKREIKILTDLSN 91 ++ Y+ K+G G Y EV + V+ IK+++ K+ E+ +L L Sbjct: 36 SEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLD- 94 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H NI+ L+D +D + LV Sbjct: 95 --------------------------------------HPNIMKLYDFFED--KRNYYLV 114 Query: 152 FEYVDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID--HK 206 E + I K +++ + ++L + Y H I+HRD+KP N++++ K Sbjct: 115 MECYKGGELFDEIIHRMKFNEVDAAVIIKQVLSGVTYLHKHNIVHRDLKPENLLLESKEK 174 Query: 207 NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 + ++++D+GL+ + + R+ + ++ PE+L + YD D+WS G +L ++ Sbjct: 175 DALIKIVDFGLSAVFENQKKMKERLGTAYYIAPEVL--RKKYDEKCDVWSIGVILFILLA 232 Query: 267 KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG 326 PF G ++ + L K+ K T D ++ Sbjct: 233 GYPPF-GGQTDQEILRKVEKGKYTFDSPEWK----------------------------- 262 Query: 327 NKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK 372 + ++ DLI +L++D Q R++A++A+ HPW + + E Sbjct: 263 ----NVSEGAKDLIKQMLQFDSQRRISAQQALEHPWIKEMCSKKES 304 >4ZSG-A nrPDB Length = 347 Score = 244 bits (623), Expect = 5e-65, Method: Composition-based stats. Identities = 79/348 (22%), Positives = 151/348 (43%), Gaps = 63/348 (18%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP-----VKKKKIKREIKILTDLSNE 92 +YEI +G G Y V + + ++ IK + K+ RE+KIL Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILK----- 61 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI----SKTP 148 H H NII + DI++ + K+ Sbjct: 62 ----------------------------------HFKHDNIIAIKDILRPTVPYGEFKSV 87 Query: 149 ALVFEYVDNVDFRILY--PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK 206 +V + +++ +I++ LT +R+++++LL+ L Y HS ++HRD+KP N++++ + Sbjct: 88 YVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVN-E 146 Query: 207 NKKLRLIDWGLAEFYHVNME-----YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTML 261 N +L++ D+G+A + VA+R+++ PEL++ Y ++DLWS G + Sbjct: 147 NCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIF 206 Query: 262 ASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 M+ +R+ F G + QL I+ VLGT + + PW Sbjct: 207 GEMLARRQ-LFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWET 265 Query: 322 FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 ++ + + L+ +LR++ R++A A+ HP+ A + Sbjct: 266 VYPGADR------QALSLLGRMLRFEPSARISAAAALRHPFLAKYHDP 307 >5AWM-A nrPDB Length = 394 Score = 243 bits (621), Expect = 7e-65, Method: Composition-based stats. Identities = 70/342 (20%), Positives = 137/342 (40%), Gaps = 59/342 (17%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML-----KPVKKKKIKREIKILTDLSNE 92 Y +G G V ++ + IK L K+ RE K++ ++ Sbjct: 44 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAKRAYREFKLMKLVN-- 101 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPIS----KTP 148 H NII L + + + Sbjct: 102 -------------------------------------HKNIIGLLNAFTPQRNLEEFQDV 124 Query: 149 ALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK 208 LV E +D +++ L + + ++++L + + HS GI+HRD+KP N+++ + Sbjct: 125 YLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV-KADC 183 Query: 209 KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 268 L+++D+GLA V +R+++ PE+++ Y ++D+WS G ++ MI Sbjct: 184 TLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVILGM-GYTENVDIWSVGCIMGEMIRGG 242 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG-- 326 F GT + DQ KI++ LGT ++ + + T+ + +Y + R DG Sbjct: 243 V-LFPGTDHIDQWNKIIEQLGTPS-PSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLF 300 Query: 327 -----NKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + +L+ +L D ++R++ EA+ H + Sbjct: 301 PNDNNQNSRRKASDARNLLSKMLVIDPEQRISVDEALKHEYI 342 >4AGU-A nrPDB Length = 311 Score = 243 bits (621), Expect = 7e-65, Method: Composition-based stats. Identities = 87/341 (25%), Positives = 146/341 (42%), Gaps = 58/341 (17%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML-----KPVKKKKIKREIKILTDLSN 91 + YE K+G G Y VF+ D+ + IK PV KK REI++L L Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLK- 60 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H N+++L ++ + + LV Sbjct: 61 --------------------------------------HPNLVNLLEVFRR--KRRLHLV 80 Query: 152 FEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK 208 FEY D+ + + + ++ ++ L+A+++CH +HRDVKP N++I K+ Sbjct: 81 FEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKHNCIHRDVKPENILIT-KHS 139 Query: 209 KLRLIDWGLAEFY-HVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 ++L D+G A + Y+ VA+R+++ PELLV Y +D+W+ G + A ++ Sbjct: 140 VIKLCDFGFARLLTGPSDYYDDEVATRWYRSPELLVGDTQYGPPVDVWAIGCVFAELLSG 199 Query: 268 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGN 327 P + G S+ DQL I K LG + +++ Y I P Sbjct: 200 -VPLWPGKSDVDQLYLIRKTLG-----DLIPRHQQVFSTNQYFSGVKIPDP-EDMEPLEL 252 Query: 328 KHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 368 K + + + L+ L D ERLT ++ + HP+F IRE Sbjct: 253 KFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIRE 293 >3MIA-A nrPDB Length = 351 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 89/361 (24%), Positives = 147/361 (40%), Gaps = 65/361 (18%) Query: 24 WDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK----- 78 Y++ + YE K+G+G + EVF+ + K+ +K + +K+ Sbjct: 3 KQYDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPIT 62 Query: 79 IKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFD 138 REIKIL L H N+++L + Sbjct: 63 ALREIKILQLLK---------------------------------------HENVVNLIE 83 Query: 139 IIK------DPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYCHSM 189 I + + + LVF++ ++ + K T EI+ M LL L Y H Sbjct: 84 ICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRN 143 Query: 190 GIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYH-----VNMEYNVRVASRFFKGPELLVD 244 I+HRD+K NV+I ++ L+L D+GLA + Y RV + +++ PELL+ Sbjct: 144 KILHRDMKAANVLIT-RDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLG 202 Query: 245 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 R Y +DLW G ++A M R P G + QL I ++ G+ E + L Sbjct: 203 ERDYGPPIDLWGAGCIMAEMWT-RSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYEL 261 Query: 305 PREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + + K R + D K + +DLID LL D +R+ + +A+ H +F Sbjct: 262 YEKLE-----LVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFW 316 Query: 365 P 365 Sbjct: 317 S 317 >3E7O-A nrPDB Length = 360 Score = 243 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 68/337 (20%), Positives = 137/337 (40%), Gaps = 48/337 (14%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 K Y+ +G G V + + +K L Sbjct: 22 KRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP----------------------- 58 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPIS----KTPALVFE 153 Q + K + H NII L ++ + + LV E Sbjct: 59 -----------FQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVME 107 Query: 154 YVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLI 213 +D ++++ +L + + ++++L + + HS GI+HRD+KP N+++ + L+++ Sbjct: 108 LMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV-KSDCTLKIL 166 Query: 214 DWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFH 273 D+GLA N V +R+++ PE+++ Y ++D+WS G ++ ++ F Sbjct: 167 DFGLARTASTNFMMTPYVVTRYYRAPEVILGM-GYKENVDIWSVGCIMGELVKGSV-IFQ 224 Query: 274 GTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYI------RKPWHRFINDGN 327 GT + DQ K+++ LGT E ++ + T+ + Y P F ++ Sbjct: 225 GTDHIDQWNKVIEQLGTPSAE-FMAALQPTVRNYVENRPAYPGIAFEELFPDWIFPSESE 283 Query: 328 KHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + + DL+ +L D +R++ EA+ HP+ Sbjct: 284 RDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYIT 320 >4E7W-A nrPDB Length = 394 Score = 243 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 96/338 (28%), Positives = 149/338 (44%), Gaps = 60/338 (17%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 Y +G G + VFQ KL ++ IK + K+ K RE++I+ + + Sbjct: 42 YTNCKVIGNGSFGVVFQA-KLVESDEVAIKKVLQDKRFK-NRELQIMRIVKH-------- 91 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKT----PALVFEYV 155 N++ L K LV EYV Sbjct: 92 -------------------------------PNVVDLKAFFYSNGDKKDEVFLNLVLEYV 120 Query: 156 DNVDFRI------LYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 +R L + L I+ YM++LL++L Y HS+GI HRD+KP N+++D + Sbjct: 121 PETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYIHSIGICHRDIKPQNLLLDPPSGV 180 Query: 210 LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 L+LID+G A+ + SR+++ PEL+ Y ++D+WS G ++A ++ + Sbjct: 181 LKLIDFGSAKILIAGEPNVSYICSRYYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQ- 239 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 P F G S DQLV+I+KVLGT E+ + +F Q P+ + Sbjct: 240 PLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEHKF---PQIRPHPFSKVFRPRTP- 295 Query: 330 LSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIR 367 + IDLI LL Y RLTA EA+ HP+F +R Sbjct: 296 ----PDAIDLISRLLEYTPSARLTAIEALCHPFFDELR 329 >5JN2-A nrPDB Length = 525 Score = 243 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 64/347 (18%), Positives = 136/347 (39%), Gaps = 88/347 (25%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP------VKKKKIKREIKILT 87 + + Y+ + +G+G + EV + + +K++ K+ + RE+++L Sbjct: 63 AIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLK 122 Query: 88 DLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKT 147 L H NI+ L++ +D Sbjct: 123 QLD---------------------------------------HPNIMKLYEFFED--KGY 141 Query: 148 PALVFEYVDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID 204 LV E + I + ++++ + ++L + Y H I+HRD+KP N++++ Sbjct: 142 FYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLE 201 Query: 205 --HKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLA 262 K+ +R+ID+GL+ + + + ++ + ++ PE+L + YD D+WS G +L Sbjct: 202 SKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVL--HGTYDEKCDVWSTGVILY 259 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 ++ PF +G + D L K+ K T + ++ Sbjct: 260 ILLSGCPPF-NGANEYDILKKVEKGKYTFELPQWK------------------------- 293 Query: 323 INDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 ++ DLI +L Y R++A++A+ H W ++ Sbjct: 294 --------KVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKE 332 >1JNK-A nrPDB Length = 423 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 71/365 (19%), Positives = 147/365 (40%), Gaps = 49/365 (13%) Query: 9 ARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVI 68 A+ Y + +++ E ++ K Y+ +G G V + I Sbjct: 34 AKHYNMSKSKVDNQFYSVEVGDSTFTV-LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAI 92 Query: 69 KMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHN 128 K L Q + K + Sbjct: 93 KKLSRP----------------------------------FQNQTHAKRAYRELVLMKCV 118 Query: 129 GHANIIHLFDIIKDPIS----KTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALD 184 H NII L ++ + + LV E +D +++ +L + + ++++L + Sbjct: 119 NHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIK 178 Query: 185 YCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVD 244 + HS GI+HRD+KP N+++ + L+++D+GLA + V +R+++ PE+++ Sbjct: 179 HLHSAGIIHRDLKPSNIVV-KSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILG 237 Query: 245 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 Y ++D+WS G ++ M+ + + F G DQ K+++ LGT E ++ K + T+ Sbjct: 238 M-GYKENVDIWSVGCIMGEMV-RHKILFPGRDYIDQWNKVIEQLGTPCPE-FMKKLQPTV 294 Query: 305 PREFYDMDQYIRKPWHR------FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAM 358 + +Y + + F D + + DL+ +L D +R++ +A+ Sbjct: 295 RNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDAL 354 Query: 359 GHPWF 363 HP+ Sbjct: 355 QHPYI 359 >5EFQ-A nrPDB Length = 347 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 78/350 (22%), Positives = 147/350 (42%), Gaps = 51/350 (14%) Query: 31 IDWSTNTKD-YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK-----IKREIK 84 IDW D ++I +G G Y +V++ D+ + +K ++ +K+ REIK Sbjct: 3 IDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIK 62 Query: 85 ILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI 144 IL L+++ + + + K+D Sbjct: 63 ILRQLTHQSIINMKEIVTDKEDALDFKKD------------------------------- 91 Query: 145 SKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNV 201 LVFEY+D+ + I+ +M +L++ LDYCH +HRD+K N+ Sbjct: 92 KGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNI 151 Query: 202 MIDHKNKKLRLIDWGLAEFY--HVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGT 259 +++++ +++L D+GLA Y + Y +V + +++ PELL+ Y ++D+WS G Sbjct: 152 LLNNRG-QIKLADFGLARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGC 210 Query: 260 MLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPW 319 +L + ++P F QL I ++ G+ + ++ QY RK Sbjct: 211 ILGELFT-KKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLR 269 Query: 320 HRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 F+ +DL D +L D +R TA++A+ + + Sbjct: 270 EEFVFIPAA-------ALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPS 312 >2XS0-A nrPDB Length = 386 Score = 241 bits (614), Expect = 4e-64, Method: Composition-based stats. Identities = 71/336 (21%), Positives = 138/336 (41%), Gaps = 48/336 (14%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 K Y+ +G G V + + IK L Sbjct: 26 KRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP----------------------- 62 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPIS----KTPALVFE 153 Q + K + H NII L ++ S + +V E Sbjct: 63 -----------FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVME 111 Query: 154 YVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLI 213 +D +++ +L + + ++++L + + HS GI+HRD+KP N+++ + L+++ Sbjct: 112 LMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV-KSDCTLKIL 170 Query: 214 DWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFH 273 D+GLA + V +R+++ PE+++ Y ++D+WS G ++ MI F Sbjct: 171 DFGLARTAGTSFMMVPFVVTRYYRAPEVILGM-GYKENVDIWSVGCIMGEMIKGGV-LFP 228 Query: 274 GTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR------FINDGN 327 GT + DQ K+++ LGT E ++ K + T+ + +Y + + F D Sbjct: 229 GTDHIDQWNKVIEQLGTPCPE-FMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSE 287 Query: 328 KHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + + DL+ +L D +R++ EA+ HP+ Sbjct: 288 HNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI 323 >4NST-A nrPDB Length = 351 Score = 241 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 78/351 (22%), Positives = 148/351 (42%), Gaps = 51/351 (14%) Query: 28 NTVIDWSTNTKD-YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK-----IKR 81 T DW D ++I +G G Y +V++ D+ + +K ++ +K+ R Sbjct: 2 QTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIR 61 Query: 82 EIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIK 141 EIKIL L + V Q + K+D F Sbjct: 62 EIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAF------------------------ 97 Query: 142 DPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKP 198 LVFEY+D+ ++ I+ +M +L++ L+YCH +HRD+K Sbjct: 98 -------YLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKC 150 Query: 199 HNVMIDHKNKKLRLIDWGLAEFYHVNME--YNVRVASRFFKGPELLVDYRMYDYSLDLWS 256 N+++++ + +++L D+GLA Y+ Y +V + +++ PELL+ Y ++D+WS Sbjct: 151 SNILLNN-SGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWS 209 Query: 257 FGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIR 316 G +L + ++P F QL I ++ G+ + ++ QY R Sbjct: 210 CGCILGELFT-KKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRR 268 Query: 317 KPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIR 367 + F + +DL+D++L D +R TA++ + + + Sbjct: 269 RLREEFSFIPSA-------ALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVE 312 >3Q5I-A nrPDB Length = 504 Score = 240 bits (613), Expect = 6e-64, Method: Composition-based stats. Identities = 77/340 (22%), Positives = 138/340 (40%), Gaps = 66/340 (19%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 + Y K+G G Y EV + + + IK++K + K Sbjct: 36 ESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDK------------------- 76 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 + E + I I H NII LFD+ +D K LV E+ + Sbjct: 77 ----GRYSDDNKNIEKFHEEIYNEISLLKSLDHPNIIKLFDVFED--KKYFYLVTEFYEG 130 Query: 158 VDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK--KLRL 212 + I K + + M ++L + Y H I+HRD+KP N+++++KN +++ Sbjct: 131 GELFEQIINRHKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKI 190 Query: 213 IDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFF 272 +D+GL+ F+ + + R+ + ++ PE+L + Y+ D+WS G ++ ++ PF Sbjct: 191 VDFGLSSFFSKDYKLRDRLGTAYYIAPEVL--KKKYNEKCDVWSCGVIMYILLCGYPPF- 247 Query: 273 HGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSG 332 G ++ D + K+ K DF + + Sbjct: 248 GGQNDQDIIKKVEKGKYYFDFNDWK---------------------------------NI 274 Query: 333 NDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK 372 +DE +LI +L YD+ +R TA+EA+ W I K Sbjct: 275 SDEAKELIKLMLTYDYNKRCTAEEALNSRWIKKYANNINK 314 >3FI2-A nrPDB Length = 353 Score = 240 bits (611), Expect = 1e-63, Method: Composition-based stats. Identities = 68/336 (20%), Positives = 137/336 (40%), Gaps = 48/336 (14%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 K Y+ +G G V + IK L Sbjct: 24 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP----------------------- 60 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPIS----KTPALVFE 153 Q + K + H NII L ++ + + LV E Sbjct: 61 -----------FQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVME 109 Query: 154 YVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLI 213 +D +++ +L + + ++++L + + HS GI+HRD+KP N+++ + L+++ Sbjct: 110 LMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV-KSDCTLKIL 168 Query: 214 DWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFH 273 D+GLA + V +R+++ PE+++ Y ++D+WS G ++ M+ + + F Sbjct: 169 DFGLARTAGTSFMMTPYVVTRYYRAPEVILGM-GYKENVDIWSVGCIMGEMV-RHKILFP 226 Query: 274 GTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR------FINDGN 327 G DQ K+++ LGT E ++ K + T+ + +Y + + F D Sbjct: 227 GRDYIDQWNKVIEQLGTPCPE-FMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSE 285 Query: 328 KHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + + DL+ +L D +R++ +A+ HP+ Sbjct: 286 HNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYI 321 >4QNY-A nrPDB Length = 354 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 76/338 (22%), Positives = 150/338 (44%), Gaps = 48/338 (14%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDS-KVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPP 96 Y +E +G G Y V + S + +K + +++ +IL ++ Sbjct: 20 DRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEVILAKRILREIK------ 73 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII--KDPISK-TPALVFE 153 H NII L +I+ +DP + +V + Sbjct: 74 ---------------------------LLAHFNDDNIIGLRNILTPEDPENFDHFYIVMD 106 Query: 154 YVDNVDFRILY--PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 ++ ++L +LT+ I+F++++ L+AL HS G++HRD+ P N++++ N L+ Sbjct: 107 IMETDLKQVLRSGQELTEAHIQFFIYQALRALHIIHSAGVIHRDITPANILVNT-NCDLK 165 Query: 212 LIDWGLAEFYHVNMEY-NVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 + D+GLA+ + EY V R+++ PEL+++ + Y +D+W G +L ++ P Sbjct: 166 ICDFGLAKEENDQGEYMTDYVTMRWYRAPELVMEDKDYSAQIDVWGIGCILGELL-GSRP 224 Query: 271 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 330 F G +QL KIV V+GT E + + W ++ Sbjct: 225 LFQGKDRVNQLDKIVDVIGTPSEEDINSVGSSAAQKYLKKKSHRPQADW------RQRYP 278 Query: 331 SGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 368 + + E +DL+ ++L ++ + R+T +AM HP+ + + Sbjct: 279 TASPEALDLLRHMLVFNPKRRITVLQAMRHPFLEQLHD 316 >5FG8-A nrPDB Length = 285 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 70/345 (20%), Positives = 142/345 (41%), Gaps = 88/345 (25%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK-----KKIKREIKILTDLSN 91 + +Y+I+ ++G+G +S V + V+ + + K++ K +K++RE +I L Sbjct: 13 SDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLH- 71 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H NI+ L D I++ LV Sbjct: 72 --------------------------------------HPNIVRLHDSIQE--ENYHYLV 91 Query: 152 FEYVDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH--K 206 F+ V + + ++ + + ++L+++++CH G++HRD+KP N+++ K Sbjct: 92 FDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAK 151 Query: 207 NKKLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 ++L D+GLA E + + + + PE+L Y S+D+W+ G +L ++ Sbjct: 152 GAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVL-KKEPYGKSVDIWACGVILYILL 210 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 PF+ D +++ L +I Y ++ Sbjct: 211 VGYPPFW-------------------DEDQHRLYSQIKAGAYDYPSPEW----------- 240 Query: 326 GNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQI 370 + E +LI+ +L + +R+TA EA+ HPW RE++ Sbjct: 241 ----DTVTPEAKNLINQMLTVNPNKRITAAEALKHPWICQ-RERV 280 >2BDW-A nrPDB Length = 362 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 68/344 (19%), Positives = 140/344 (40%), Gaps = 87/344 (25%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK-----KKIKREIKILTDLSN 91 + +Y+++ ++G+G +S V + V + ++ K++ K +K++RE +I L Sbjct: 28 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQ- 86 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H NI+ L D I++ LV Sbjct: 87 --------------------------------------HPNIVRLHDSIQE--ESFHYLV 106 Query: 152 FEYVDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH--K 206 F+ V + + ++ + + ++L+++ YCHS GI+HR++KP N+++ K Sbjct: 107 FDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHRNLKPENLLLASKAK 166 Query: 207 NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 ++L D+GLA + + ++ + + PE+L Y +D+W+ G +L ++ Sbjct: 167 GAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL-KKDPYSKPVDIWACGVILYILLV 225 Query: 267 KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG 326 PF+ + +L +K P +D Sbjct: 226 GYPPFW--DEDQHRLYAQIKA------------GAYDYPSPEWD---------------- 255 Query: 327 NKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQI 370 + E LID++L + ++R+TA +A+ PW RE++ Sbjct: 256 ----TVTPEAKSLIDSMLTVNPKKRITADQALKVPWICN-RERV 294 >2VN9-A nrPDB Length = 301 Score = 238 bits (606), Expect = 3e-63, Method: Composition-based stats. Identities = 70/340 (20%), Positives = 135/340 (39%), Gaps = 87/340 (25%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVK-----KKKIKREIKILTDLSN 91 T +Y++ ++G+G +S V + +K+ + + K++ K +K++RE +I L Sbjct: 3 TDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLK- 61 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H NI+ L D I + LV Sbjct: 62 --------------------------------------HPNIVRLHDSISE--EGFHYLV 81 Query: 152 FEYVDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID--HK 206 F+ V + + ++ + + ++L+++++CH GI+HRD+KP N+++ K Sbjct: 82 FDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSK 141 Query: 207 NKKLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 ++L D+GLA E + + + PE+L Y +D+W+ G +L ++ Sbjct: 142 GAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK-DPYGKPVDMWACGVILYILL 200 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 PF+ + +L + +K G DF Sbjct: 201 VGYPPFW--DEDQHRLYQQIKA-GAYDF-------------------------------P 226 Query: 326 GNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 + + E DLI+ +L + +R+TA EA+ HPW Sbjct: 227 SPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQ 266 >2W4O-A nrPDB Length = 349 Score = 238 bits (606), Expect = 4e-63, Method: Composition-based stats. Identities = 72/332 (21%), Positives = 131/332 (39%), Gaps = 81/332 (24%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKR-EIKILTDLSNEKVP 95 + +E+E+++GRG S V++ + ++ +K+LK KKI R EI +L LS Sbjct: 52 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLS----- 106 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 H NII L +I + P +LV E V Sbjct: 107 ----------------------------------HPNIIKLKEIFETPTE--ISLVLELV 130 Query: 156 DNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID--HKNKKL 210 + + ++ + + ++L+A+ Y H GI+HRD+KP N++ + L Sbjct: 131 TGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPL 190 Query: 211 RLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 ++ D+GL++ + + + PE+L Y +D+WS G + ++ EP Sbjct: 191 KIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGC-AYGPEVDMWSVGIITYILLCGFEP 249 Query: 271 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 330 F+ + +I+ + Y PW ++ Sbjct: 250 FYDERGDQFMFRRILNC------------------------EYYFISPWWDEVSLN---- 281 Query: 331 SGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 DL+ L+ D ++RLT +A+ HPW Sbjct: 282 -----AKDLVRKLIVLDPKKRLTTFQALQHPW 308 >4YZB-A nrPDB Length = 491 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 61/336 (18%), Positives = 130/336 (38%), Gaps = 76/336 (22%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPP 96 + Y+ + +G+G + EV + + +K++ + K+ Sbjct: 29 SDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQ------------------ 70 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 + + + + H NI+ L++ +D LV E Sbjct: 71 ---------------KTDKELLLKEVELLKKLDHPNIMKLYEFFED--KGYFYLVTEVYT 113 Query: 157 NVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH--KNKKLR 211 + I + ++++ + ++L + Y H I+HRD+KP N+++++ K+ +R Sbjct: 114 GGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIR 173 Query: 212 LIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 +ID+GL+ + + ++ + ++ PE+L + YD D+WS G +L ++ PF Sbjct: 174 IIDFGLSTHFESTKKMKDKIGTAYYIAPEVL--HGTYDEKCDVWSTGVILYILLSGCPPF 231 Query: 272 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLS 331 +G + D L K+ K T D ++ Sbjct: 232 -NGANEFDILKKVEKGKFTFDLPQWK---------------------------------K 257 Query: 332 GNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIR 367 ++ DLI +L Y R++A++A+ H W Sbjct: 258 VSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTTD 293 >2V7O-A nrPDB Length = 336 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 69/351 (19%), Positives = 135/351 (38%), Gaps = 87/351 (24%) Query: 26 YENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVK-----KKKIK 80 Y ++ + T DY++ ++G+G +S V + VK + K++ K +K++ Sbjct: 19 YFQSMATCTRFTDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLE 78 Query: 81 REIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII 140 RE +I L H NI+ L D I Sbjct: 79 REARICRLLK---------------------------------------HPNIVRLHDSI 99 Query: 141 KDPISKTPALVFEYVDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVK 197 + LVF+ V + + ++ + + ++L+++++ H I+HRD+K Sbjct: 100 SE--EGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLK 157 Query: 198 PHNVMIDH--KNKKLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDL 254 P N+++ K ++L D+GLA E + + + PE+L Y +D+ Sbjct: 158 PENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRK-DPYGKPVDI 216 Query: 255 WSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQY 314 W+ G +L ++ PF+ + +L + +K G DF Sbjct: 217 WACGVILYILLVGYPPFW--DEDQHKLYQQIKA-GAYDF--------------------- 252 Query: 315 IRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 + + E +LI+ +L + +R+TA +A+ HPW Sbjct: 253 ----------PSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQ 293 >3MA6-A nrPDB Length = 298 Score = 237 bits (604), Expect = 7e-63, Method: Composition-based stats. Identities = 64/347 (18%), Positives = 136/347 (39%), Gaps = 88/347 (25%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP------VKKKKIKREIKILT 87 + + Y+ + +G+G + EV + + +K++ K+ + RE+++L Sbjct: 28 AIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLK 87 Query: 88 DLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKT 147 L H NI+ L++ +D Sbjct: 88 QLD---------------------------------------HPNIMKLYEFFED--KGY 106 Query: 148 PALVFEYVDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID 204 LV E + I + ++++ + ++L + Y H I+HRD+KP N++++ Sbjct: 107 FYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLE 166 Query: 205 --HKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLA 262 K+ +R+ID+GL+ + + + ++ + ++ PE+L + YD D+WS G +L Sbjct: 167 SKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVL--HGTYDEKCDVWSTGVILY 224 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 ++ PF +G + D L K+ K T + ++ Sbjct: 225 ILLSGCPPF-NGANEYDILKKVEKGKYTFELPQWK------------------------- 258 Query: 323 INDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 ++ DLI +L Y R++A++A+ H W ++ Sbjct: 259 --------KVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKE 297 >3SOA-A nrPDB Length = 444 Score = 236 bits (603), Expect = 8e-63, Method: Composition-based stats. Identities = 72/349 (20%), Positives = 137/349 (39%), Gaps = 87/349 (24%) Query: 28 NTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIV-----IKMLKPVKKKKIKRE 82 I + T++Y++ ++G+G +S V + VK+ + + K L +K++RE Sbjct: 1 MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLERE 60 Query: 83 IKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD 142 +I L H NI+ L D I + Sbjct: 61 ARICRLLK---------------------------------------HPNIVRLHDSISE 81 Query: 143 PISKTPALVFEYVDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPH 199 L+F+ V + + ++ + + ++L+A+ +CH MG++HR++KP Sbjct: 82 --EGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRNLKPE 139 Query: 200 NVMIDH--KNKKLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWS 256 N+++ K ++L D+GLA E + + + PE+L Y +DLW+ Sbjct: 140 NLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK-DPYGKPVDLWA 198 Query: 257 FGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIR 316 G +L ++ PF+ + +L + +K G DF Sbjct: 199 CGVILYILLVGYPPFW--DEDQHRLYQQIKA-GAYDF----------------------- 232 Query: 317 KPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 + + E DLI+ +L + +R+TA EA+ HPW + Sbjct: 233 --------PSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISH 273 >3PG1-A nrPDB Length = 362 Score = 236 bits (603), Expect = 9e-63, Method: Composition-based stats. Identities = 73/339 (21%), Positives = 152/339 (44%), Gaps = 41/339 (12%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 Y ++ + G Y V GV + + + IK + R + IL+D Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDG--RTVNILSD----------- 69 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII---KDPISKTPALVFEYVD 156 + K + I H H NI+ L DI ++P LV E + Sbjct: 70 ------------SFLCKRVLREIRLLNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMR 117 Query: 157 NVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLI 213 ++++ + ++ I+++M+ +L L H G++HRD+ P N+++ N + + Sbjct: 118 TDLAQVIHDQRIVISPQHIQYFMYHILLGLHVLHEAGVVHRDLHPGNILL-ADNNDITIC 176 Query: 214 DWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFH 273 D+ LA + V R+++ PEL++ ++ + +D+WS G ++A M ++ F Sbjct: 177 DFNLAREDTADANKTHYVTHRWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKA-LFR 235 Query: 274 GTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYD-MDQYIRKPWHRFINDGNKHLSG 332 G++ +QL KIV+V+GT E ++ + + + + W + + Sbjct: 236 GSTFYNQLNKIVEVVGTPKIEDVVMFSSPSARDYLRNSLSNVPARAWTAVVP------TA 289 Query: 333 NDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIE 371 + +DLI +L ++ Q R++ ++A+ HP+F + + ++ Sbjct: 290 DPVALDLIAKMLEFNPQRRISTEQALRHPYFESLFDPLD 328 >5U6Y-A nrPDB Length = 461 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 71/337 (21%), Positives = 134/337 (39%), Gaps = 87/337 (25%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVK-----KKKIKREIKILTDLSNEKV 94 Y++ ++G+G +S V + VK+ + + K++ K +K++RE +I L Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLK---- 57 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 H NI+ L D I + L+F+ Sbjct: 58 -----------------------------------HPNIVRLHDSISE--EGHHYLIFDL 80 Query: 155 VDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH--KNKK 209 V + + ++ + + ++L+A+ +CH MG++HRD+KP N+++ K Sbjct: 81 VTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAA 140 Query: 210 LRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 268 ++L D+GLA E + + + PE+L Y +DLW+ G +L ++ Sbjct: 141 VKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK-DPYGKPVDLWACGVILYILLVGY 199 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 PF+ + +L + +K G DF + Sbjct: 200 PPFW--DEDQHRLYQQIKA-GAYDF-------------------------------PSPE 225 Query: 329 HLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 + E DLI+ +L + +R+TA EA+ HPW + Sbjct: 226 WDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISH 262 >3KK8-A nrPDB Length = 284 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 68/344 (19%), Positives = 140/344 (40%), Gaps = 87/344 (25%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK-----KKIKREIKILTDLSN 91 + +Y+++ ++G+G +S V + V + ++ K++ K +K++RE +I L Sbjct: 5 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQ- 63 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H NI+ L D I++ LV Sbjct: 64 --------------------------------------HPNIVRLHDSIQE--ESFHYLV 83 Query: 152 FEYVDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH--K 206 F+ V + + ++ + + ++L+++ YCHS GI+HR++KP N+++ K Sbjct: 84 FDLVTGGELFEDIVAREFYSEADASHCIQQILESIAYCHSNGIVHRNLKPENLLLASKAK 143 Query: 207 NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 ++L D+GLA + + ++ + + PE+L Y +D+W+ G +L ++ Sbjct: 144 GAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPEVL-KKDPYSKPVDIWACGVILYILLV 202 Query: 267 KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG 326 PF+ + +L +K P +D Sbjct: 203 GYPPFW--DEDQHRLYAQIKA------------GAYDYPSPEWD---------------- 232 Query: 327 NKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQI 370 + E LID++L + ++R+TA +A+ PW RE++ Sbjct: 233 ----TVTPEAKSLIDSMLTVNPKKRITADQALKVPWICN-RERV 271 >2Y7J-A nrPDB Length = 365 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 81/378 (21%), Positives = 154/378 (40%), Gaps = 79/378 (20%) Query: 2 KCRVWSEARVYTNINKQRTEEYW----DYENTVIDWSTNTKDYEI---ENKVGRGKYSEV 54 + +EA+ + + TE + E+ + DW+ + Y+ ++ +GRG S V Sbjct: 51 SANLLAEAKKLNDAQPKGTENLYFQSMGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVV 110 Query: 55 FQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDV 114 + V + + +K+++ + LS E++ +++ + Q Sbjct: 111 RRCVHRATGHEFAVKIMEVTAE-----------RLSPEQLEEVREATRRETHILRQV--- 156 Query: 115 LKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK---LTDLE 171 GH +II L D + S LVF+ + + + L++ E Sbjct: 157 -------------AGHPHIITLIDSYES--SSFMFLVFDLMRKGELFDYLTEKVALSEKE 201 Query: 172 IRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRV 231 R M LL+A+ + H+ I+HRD+KP N+++D N ++RL D+G + + Sbjct: 202 TRSIMRSLLEAVSFLHANNIVHRDLKPENILLD-DNMQIRLSDFGFSCHLEPGEKLRELC 260 Query: 232 ASRFFKGPELLV-----DYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVK 286 + + PE+L + Y +DLW+ G +L +++ PF+H Sbjct: 261 GTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWH------------- 307 Query: 287 VLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRY 346 R M + I + ++F + S + DLI LL+ Sbjct: 308 -------------------RRQILMLRMIMEGQYQFSSPEWDDRSST--VKDLISRLLQV 346 Query: 347 DHQERLTAKEAMGHPWFA 364 D + RLTA++A+ HP+F Sbjct: 347 DPEARLTAEQALQHPFFE 364 >5G6V-A nrPDB Length = 324 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 85/344 (24%), Positives = 156/344 (45%), Gaps = 58/344 (16%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKK----KIKREIKILTDLSNE 92 + Y +K+G G Y+ V++G + + +K ++ ++ RE+ +L DL Sbjct: 1 METYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLK-- 58 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF 152 HANI+ L DII K+ LVF Sbjct: 59 -------------------------------------HANIVTLHDIIH--TEKSLTLVF 79 Query: 153 EYVDNVD---FRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 EY+D + ++ ++F+LL+ L YCH ++HRD+KP N++I+ + + Sbjct: 80 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLIN-ERGE 138 Query: 210 LRLIDWGLAEFYH-VNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 268 L+L D+GLA Y+ V + +++ P++L+ Y +D+W G + M R Sbjct: 139 LKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGR 198 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 P F G++ +QL I ++LGT E + L E + Y + ++ + Sbjct: 199 -PLFPGSTVEEQLHFIFRILGTPTEETW----PGILSNEEFKTYNYPKYRAEALLSHAPR 253 Query: 329 HLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK 372 + + DL+ LL+++ + R++A++AM HP+F + E+I K Sbjct: 254 ---LDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHK 294 >4BBM-A nrPDB Length = 331 Score = 234 bits (597), Expect = 4e-62, Method: Composition-based stats. Identities = 85/338 (25%), Positives = 143/338 (42%), Gaps = 58/338 (17%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML-----KPVKKKKIKREIKILTDLS 90 + + YE VG G Y V + D+ + IK + KK REIK+L L Sbjct: 23 SMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLR 82 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 H N+++L ++ K K L Sbjct: 83 ---------------------------------------HENLVNLLEVCKK--KKRWYL 101 Query: 151 VFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN 207 VFE+VD+ D + L ++ Y+F+++ + +CHS I+HRD+KP N+++ ++ Sbjct: 102 VFEFVDHTILDDLELFPNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPENILVS-QS 160 Query: 208 KKLRLIDWGLAEFYHVNME-YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 ++L D+G A E Y+ VA+R+++ PELLV Y ++D+W+ G ++ M Sbjct: 161 GVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELLVGDVKYGKAVDVWAIGCLVTEMFM 220 Query: 267 KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG 326 P F G S+ DQL I+ LG L + + + R+P R Sbjct: 221 GE-PLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFAGVRLPEIKEREPLER----- 274 Query: 327 NKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 ++ ++ +IDL L D +R E + H +F Sbjct: 275 -RYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 311 >2VZ6-A nrPDB Length = 313 Score = 234 bits (597), Expect = 4e-62, Method: Composition-based stats. Identities = 71/337 (21%), Positives = 134/337 (39%), Gaps = 87/337 (25%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVK-----KKKIKREIKILTDLSNEKV 94 Y++ ++G+G +S V + VK+ + + K++ K +K++RE +I L Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLK---- 79 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 H NI+ L D I + L+F+ Sbjct: 80 -----------------------------------HPNIVRLHDSISE--EGHHYLIFDL 102 Query: 155 VDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH--KNKK 209 V + + ++ + + ++L+A+ +CH MG++HRD+KP N+++ K Sbjct: 103 VTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAA 162 Query: 210 LRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 268 ++L D+GLA E + + + PE+L Y +DLW+ G +L ++ Sbjct: 163 VKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRK-DPYGKPVDLWACGVILYILLVGY 221 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 PF+ + +L + +K G DF + Sbjct: 222 PPFW--DEDQHRLYQQIKA-GAYDF-------------------------------PSPE 247 Query: 329 HLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 + E DLI+ +L + +R+TA EA+ HPW + Sbjct: 248 WDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISH 284 >3GC0-A nrPDB Length = 329 Score = 233 bits (595), Expect = 7e-62, Method: Composition-based stats. Identities = 79/344 (22%), Positives = 149/344 (43%), Gaps = 61/344 (17%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK-----IKREIKILTD 88 +T+ Y K+G G Y EV++ + + + IK ++ +++ RE+ +L + Sbjct: 30 ATSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTAIREVSLLKE 89 Query: 89 LSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTP 148 L H NII L +I + Sbjct: 90 LQ---------------------------------------HRNIIELKSVIHH--NHRL 108 Query: 149 ALVFEYVDNVD--FRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID-- 204 L+FEY +N + P ++ I+ ++++L+ +++CHS +HRD+KP N+++ Sbjct: 109 HLIFEYAENDLKKYMDKNPDVSMRVIKSFLYQLINGVNFCHSRRCLHRDLKPQNLLLSVS 168 Query: 205 --HKNKKLRLIDWGLAEFYHVN-MEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTML 261 + L++ D+GLA + + ++ + + +++ PE+L+ R Y S+D+WS + Sbjct: 169 DASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEILLGSRHYSTSVDIWSIACIW 228 Query: 262 ASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 A M+ + P F G S DQL KI +VLG D + LP ++ K R Sbjct: 229 AEMLM-KTPLFPGDSEIDQLFKIFEVLGLPDDTTW--PGVTALPDWKQSFPKFRGKTLKR 285 Query: 322 FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 + + +L D +R++AK A+ HP+F+ Sbjct: 286 VLGALLDDEGLDLL-----TAMLEMDPVKRISAKNALEHPYFSH 324 >2W96-B nrPDB Length = 306 Score = 231 bits (589), Expect = 3e-61, Method: Composition-based stats. Identities = 80/342 (23%), Positives = 144/342 (42%), Gaps = 63/342 (18%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK-----IKREIKILTDL 89 T YE ++G G Y V++ S + +K ++ ++ RE+ +L L Sbjct: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRL 60 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII---KDPISK 146 H N++ L D+ + Sbjct: 61 E------------------------------------AFEHPNVVRLMDVCATSRTDREI 84 Query: 147 TPALVFEYVDNVDFRILYPK-----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNV 201 LVFE+VD D R K L I+ M + L+ LD+ H+ I+HRD+KP N+ Sbjct: 85 KVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENI 143 Query: 202 MIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTML 261 ++ ++L D+GLA Y M + V + +++ PE+L+ Y +D+WS G + Sbjct: 144 LVTS-GGTVKLADFGLARIYSYQMALDPVVVTLWYRAPEVLLQ-STYATPVDMWSVGCIF 201 Query: 262 ASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 A M F+R+P F G S DQL KI ++G + + +++LPR + +P Sbjct: 202 AEM-FRRKPLFCGNSEADQLGKIFDLIGLPPEDDW--PRDVSLPRGAF--PPRGPRPVQS 256 Query: 322 FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + + + + L+ +L ++ +R++A A+ H + Sbjct: 257 VVPEMEESGAQ------LLLEMLTFNPHKRISAFRALQHSYL 292 >3BHH-A nrPDB Length = 295 Score = 230 bits (587), Expect = 6e-61, Method: Composition-based stats. Identities = 72/340 (21%), Positives = 135/340 (39%), Gaps = 87/340 (25%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVK-----KKKIKREIKILTDLSN 91 T +Y++ +G+G +S V + VKL + + K++ K +K++RE +I L Sbjct: 3 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLK- 61 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H+NI+ L D I + LV Sbjct: 62 --------------------------------------HSNIVRLHDSISE--EGFHYLV 81 Query: 152 FEYVDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH--K 206 F+ V + + ++ + + ++L+A+ +CH MG++HRD+KP N+++ K Sbjct: 82 FDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCK 141 Query: 207 NKKLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 ++L D+GLA E + + + PE+L Y +D+W+ G +L ++ Sbjct: 142 GAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRK-EAYGKPVDIWACGVILYILL 200 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 PF+ + +L + +K G DF Sbjct: 201 VGYPPFW--DEDQHKLYQQIKA-GAYDF-------------------------------P 226 Query: 326 GNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 + + E +LI+ +L + +R+TA EA+ HPW Sbjct: 227 SPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQ 266 >3E3P-A nrPDB Length = 360 Score = 230 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 79/343 (23%), Positives = 152/343 (44%), Gaps = 38/343 (11%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLS--N 91 +++E G+G + V G + + + + IK + + + RE++I+ DL+ + Sbjct: 19 RKEMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFR-NRELQIMQDLAVLH 77 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 + ++++ L + Y+ D H N + ++ P L Sbjct: 78 HPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRN------YYRRQVAPPPIL- 130 Query: 152 FEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCH--SMGIMHRDVKPHNVMIDHKNKK 209 I+ ++F+L++++ H S+ + HRD+KPHNV+++ + Sbjct: 131 --------------------IKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGT 170 Query: 210 LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 L+L D+G A+ + + SR+++ PEL+ + Y ++D+WS G + A M+ Sbjct: 171 LKLCDFGSAKKLSPSEPNVAYICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGE- 229 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 P F G ++ QL +IV+VLG E + Y+ PW +D + Sbjct: 230 PIFRGDNSAGQLHEIVRVLGCPSREVLRKLNPSHTDVDLYNSKGI---PWSNVFSDHS-- 284 Query: 330 LSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK 372 L E DL+ LL+Y +ER+ EA+ HP+F + + K Sbjct: 285 LKDAKEAYDLLSALLQYLPEERMKPYEALCHPYFDELHDPATK 327 >3F3Z-A nrPDB Length = 277 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 70/333 (21%), Positives = 132/333 (39%), Gaps = 85/333 (25%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP---VKKKKIKREIKILTDLSNEKVPP 96 Y +EN +GRG + EV V+ ++++ K + + K+EI+I+ L Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIMKSLD------ 64 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 H NII L++ +D LV E Sbjct: 65 ---------------------------------HPNIIRLYETFEDNTD--IYLVMELCT 89 Query: 157 NVDF--RILYPK-LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI--DHKNKKLR 211 + R+++ + + + M ++L A+ YCH + + HRD+KP N + D + L+ Sbjct: 90 GGELFERVVHKRVFRESDAARIMKDVLSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLK 149 Query: 212 LIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 LID+GLA + +V + ++ P++L +Y D WS G M+ ++ PF Sbjct: 150 LIDFGLAARFKPGKMMRTKVGTPYYVSPQVLEG--LYGPECDEWSAGVMMYVLLCGYPPF 207 Query: 272 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLS 331 ++++ ++KI + T + + L+ Sbjct: 208 -SAPTDSEVMLKIREGTFTFPEKDW---------------------------------LN 233 Query: 332 GNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + + LI LL ++R+T+ +A+ H WF Sbjct: 234 VSPQAESLIRRLLTKSPKQRITSLQALEHEWFE 266 >2QNJ-A nrPDB Length = 328 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 70/355 (19%), Positives = 152/355 (42%), Gaps = 65/355 (18%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKM-----LKPVKKKKIKREIKIL 86 D + +Y + +G+G +++V + + ++ IK+ L P +K+ RE++I+ Sbjct: 6 DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIM 65 Query: 87 TDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISK 146 L+ H NI+ LF++I+ K Sbjct: 66 KILN---------------------------------------HPNIVKLFEVIE--TEK 84 Query: 147 TPALVFEYVDNV---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI 203 T L+ EY D+ + + ++ + E R +++ A+ YCH I+HRD+K N+++ Sbjct: 85 TLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLL 144 Query: 204 DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLAS 263 D + +++ D+G + + V + + S + PEL + +D+WS G +L + Sbjct: 145 DA-DMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYT 203 Query: 264 MIFKREPFFHGTSNTDQLVKIVKV------LGTSDFEKYLLKYEITLPREFYDMDQYIRK 317 ++ PF G + + ++++ ++D E L ++ + P + ++Q ++ Sbjct: 204 LVSGSLPF-DGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKD 262 Query: 318 PWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK 372 W ++ DE+ ++ L Q+R+ MG+ I+E + K Sbjct: 263 RWINAGHEE-------DELKPFVEPELDISDQKRIDIMVGMGYSQ-EEIQESLSK 309 >5IG1-A nrPDB Length = 344 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 67/330 (20%), Positives = 122/330 (36%), Gaps = 86/330 (26%) Query: 45 KVGRGKYSEVFQGVKLDSKVKIVIKM-----LKPVKKKKIKREIKILTDLSNEKVPPTTL 99 +G+G +S V + V + +K+ L+ + KIKREI I + L Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEINKIKREIGICSSLQ--------- 74 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVD 159 H +I+ + +D LVFEYV + Sbjct: 75 ------------------------------HEHIVSMRRAFRD--ESHFYLVFEYVSGGE 102 Query: 160 F---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK--NKKLRLID 214 + + + M ++L AL +CHS I+HRD+KP N+++ K N +++ D Sbjct: 103 LFDEIVTRKFYNEKDASACMHQILSALQHCHSKNIIHRDLKPENLLLASKDPNAPVKITD 162 Query: 215 WGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHG 274 +GLA Y + + PE++ YD ++D+W+ G +L ++ PF+ Sbjct: 163 FGLAVIMEQGPTYFGFAGTPGYLSPEVIR-RVPYDTAVDVWACGVILYILLVGYPPFW-E 220 Query: 275 TSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGND 334 + +I + + F + ++ Sbjct: 221 EDHQKLYAQI-------------------------------KNCQYDFPSPEWDSVTTA- 248 Query: 335 EIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 +LI +L + + R T +E + HPW A Sbjct: 249 -AKELIKAMLEPNPKRRPTVQELLQHPWIA 277 >4REW-A nrPDB Length = 540 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 70/335 (20%), Positives = 125/335 (37%), Gaps = 77/335 (22%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 93 S Y + + +G G + +V G + K+ +K+L K + + Sbjct: 2 SVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSL-------------- 47 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 DV+ IR I + H +II L+ +I P +V E Sbjct: 48 -------------------DVVGKIRREIQNLKLFRHPHIIKLYQVISTPSD--IFMVME 86 Query: 154 YVDNV---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 YV D+ +L + E R ++L +DYCH ++HRD+KP NV++D + Sbjct: 87 YVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDA-HMNA 145 Query: 211 RLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 ++ D+GL+ S + PE++ +D+WS G +L +++ P Sbjct: 146 KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLP 205 Query: 271 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 330 F + D + + K + F QY+ Sbjct: 206 F-----DDDHVPTLFKKICDGIFY----------------TPQYL--------------- 229 Query: 331 SGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 N +I L+ ++L+ D +R + K+ H WF Sbjct: 230 --NPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ 262 >4O2Z-A nrPDB Length = 377 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 79/359 (22%), Positives = 156/359 (43%), Gaps = 53/359 (14%) Query: 22 EYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPV-----KK 76 ++ Y + + +K Y + +G G Y + D+ K+ IK + V Sbjct: 30 DFKVYNVSGSPFEVPSK-YTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDG 88 Query: 77 KKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHL 136 K++ REI ++ +E + ++L ++ Sbjct: 89 KRVLREIDMMRFFHHENLLNVV--------------NILPPLKRE--------------- 119 Query: 137 FDIIKDPISKTPALVFEYVDNVDFRILYPK--LTDLEIRFYMFELLKALDYCHSMGIMHR 194 + +D +V +D +L + L + ++++++++L+ L Y HS + HR Sbjct: 120 YHSFED-----VYVVTPLMDVDMNVVLRSRQVLEESHMQYFVYQILRGLKYLHSANVAHR 174 Query: 195 DVKPHNVMIDHKNKKLRLIDWGLAEFYHVN-MEYNVRVASRFFKGPELLVDYRMYDYSLD 253 D+KP N ++ + + +L++ID+GL+ V E V +R+++ PELL++ Y ++D Sbjct: 175 DLKPAN-LVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWYRPPELLLENTNYSTAVD 233 Query: 254 LWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQ 313 +WS G + A M + R+P F G + DQL I + +G + + E D Sbjct: 234 IWSVGCIFAEM-YNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHREALEKLNELPDGSL 292 Query: 314 YIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK 372 I K L+GN E ID + + D +R TA + + HP+ A + ++ ++ Sbjct: 293 NIPK--------LVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHDEEDE 343 >5ES1-A nrPDB Length = 328 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 59/333 (17%), Positives = 128/333 (38%), Gaps = 88/333 (26%) Query: 39 DYEIENKVGRGKYSEVFQGVKLDSKVKIVIKM-----LKPVKKKKIKREIKILTDLSNEK 93 +Y + +G+G +++V + + ++ IK+ L P +K+ RE++I+ L+ Sbjct: 16 NYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLN--- 72 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 H NI+ LF++I+ KT LV E Sbjct: 73 ------------------------------------HPNIVKLFEVIE--TEKTLYLVME 94 Query: 154 YVDNV---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 Y D+ + + ++ + E R +++ A+ YCH I+HRD+K N+++D + + Sbjct: 95 YASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAE-ANI 153 Query: 211 RLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 ++ D+G + + + + + S + PEL + +D+WS G +L +++ P Sbjct: 154 KIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLP 213 Query: 271 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 330 F G + + ++++ F Sbjct: 214 F-DGHNLKELRERVLRGKYRVPFYM----------------------------------- 237 Query: 331 SGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + + ++ L + +R T ++ M W Sbjct: 238 --STDCESILRRFLVLNPAKRCTLEQIMKDKWI 268 >2HAK-A nrPDB Length = 328 Score = 228 bits (580), Expect = 5e-60, Method: Composition-based stats. Identities = 64/345 (18%), Positives = 143/345 (41%), Gaps = 64/345 (18%) Query: 28 NTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKM-----LKPVKKKKIKRE 82 + D + +Y ++ +G+G +++V + + ++ +K+ L P +K+ RE Sbjct: 5 TSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFRE 64 Query: 83 IKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD 142 ++I+ L+ H NI+ LF++I+ Sbjct: 65 VRIMKILN---------------------------------------HPNIVKLFEVIE- 84 Query: 143 PISKTPALVFEYVDNV---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPH 199 KT LV EY D+ + + ++ + E R +++ A+ YCH I+HRD+K Sbjct: 85 -TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAE 143 Query: 200 NVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGT 259 N+++D + +++ D+G + + V + + S + PEL + +D+WS G Sbjct: 144 NLLLD-GDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGV 202 Query: 260 MLASMIFKREPFFHGTSNTDQLVKIVKV------LGTSDFEKYLLKYEITLPREFYDMDQ 313 +L +++ PF G + + ++++ ++D E L K + P + ++Q Sbjct: 203 ILYTLVSGSLPF-DGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQ 261 Query: 314 YIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAM 358 ++ W ++ + + D + +R+ M Sbjct: 262 IMKDRWMNVGHEEEELKPYTEPDPDF-------NDTKRIDIMVTM 299 >6C9D-A nrPDB Length = 459 Score = 227 bits (578), Expect = 7e-60, Method: Composition-based stats. Identities = 64/345 (18%), Positives = 143/345 (41%), Gaps = 64/345 (18%) Query: 28 NTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKM-----LKPVKKKKIKRE 82 + D + +Y ++ +G+G +++V + + ++ +K+ L P +K+ RE Sbjct: 11 TSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFRE 70 Query: 83 IKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD 142 ++I+ L+ H NI+ LF++I+ Sbjct: 71 VRIMKILN---------------------------------------HPNIVKLFEVIE- 90 Query: 143 PISKTPALVFEYVDNV---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPH 199 KT LV EY D+ + + ++ + E R +++ A+ YCH I+HRD+K Sbjct: 91 -TEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKYIVHRDLKAE 149 Query: 200 NVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGT 259 N+++D + +++ D+G + + V + + S + PEL + +D+WS G Sbjct: 150 NLLLD-GDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPELFQGKKYDGPEVDVWSLGV 208 Query: 260 MLASMIFKREPFFHGTSNTDQLVKIVKV------LGTSDFEKYLLKYEITLPREFYDMDQ 313 +L +++ PF G + + ++++ ++D E L K + P + ++Q Sbjct: 209 ILYTLVSGSLPF-DGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGSLEQ 267 Query: 314 YIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAM 358 ++ W ++ + + D + +R+ M Sbjct: 268 IMKDRWMNVGHEEEELKPYTEPDPDF-------NDTKRIDIMVTM 305 >2JC6-A nrPDB Length = 334 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 68/346 (19%), Positives = 124/346 (35%), Gaps = 89/346 (25%) Query: 32 DWSTNTKD----YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPV----KKKKIKREI 83 W +D +E + +G G +SEV + + +K + K+ I+ EI Sbjct: 12 SWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIENEI 71 Query: 84 KILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP 143 +L + H NI+ L DI + P Sbjct: 72 AVLRKIK---------------------------------------HENIVALEDIYESP 92 Query: 144 ISKTPALVFEYVDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHN 200 LV + V + + T+ + + ++L A+ Y H MGI+HRD+KP N Sbjct: 93 --NHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPEN 150 Query: 201 VMI--DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFG 258 ++ + K+ + D+GL++ + + + PE+L + Y ++D WS G Sbjct: 151 LLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQ-KPYSKAVDCWSIG 209 Query: 259 TMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKP 318 + ++ PF+ +++ +I+K D + Sbjct: 210 VIAYILLCGYPPFYD-ENDSKLFEQILKAEYEFDSPYWD--------------------- 247 Query: 319 WHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 +D D I NL+ D +R T ++A HPW A Sbjct: 248 ------------DISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIA 281 >3N9X-A nrPDB Length = 432 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 84/394 (21%), Positives = 161/394 (40%), Gaps = 108/394 (27%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPV-----KKKKIKREIKILTDLSN 91 +Y I++ +GRG Y V+ +++ + IK + + K+I REI IL L + Sbjct: 25 PDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKS 84 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI---SKTP 148 + II L+D+I Sbjct: 85 DY---------------------------------------IIRLYDLIIPDDLLKFDEL 105 Query: 149 ALVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 +V E D+ D + L+ LT+ I+ ++ LL ++ H GI+HRD+KP N +++ Sbjct: 106 YIVLEIADS-DLKKLFKTPIFLTEEHIKTILYNLLLGENFIHESGIIHRDLKPANCLLN- 163 Query: 206 KNKKLRLIDWGLAEFYHV-----------------------NMEYNVRVASRFFKGPELL 242 ++ +++ D+GLA + + V +R+++ PEL+ Sbjct: 164 QDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELI 223 Query: 243 VDYRMYDYSLDLWSFGTMLASMI----------FKREPFFHGT----------------- 275 + Y S+D+WS G + A ++ R P F G+ Sbjct: 224 LLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEK 283 Query: 276 SNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDE 335 SN DQL I ++GT + + + + P + IN K+ S +D+ Sbjct: 284 SNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLF------PHRKPINLKQKYPSISDD 337 Query: 336 IIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 I+L++++L+++ +R+T +A+ HP+ +R++ Sbjct: 338 GINLLESMLKFNPNKRITIDQALDHPYLKDVRKK 371 >3NIE-A nrPDB Length = 429 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 89/408 (21%), Positives = 163/408 (39%), Gaps = 111/408 (27%) Query: 26 YENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPV-----KKKKIK 80 ++ +I +YEI++ +GRG Y V+ ++ + IK + + K+I Sbjct: 16 FQGAIIKNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRIL 75 Query: 81 REIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII 140 REI IL L ++ II L D+I Sbjct: 76 REITILNRLKSDY---------------------------------------IIRLHDLI 96 Query: 141 KDPI---SKTPALVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHR 194 +V E D+ D + L+ LT+ ++ ++ LL + H GI+HR Sbjct: 97 IPEDLLKFDELYIVLEIADS-DLKKLFKTPIFLTEQHVKTILYNLLLGEKFIHESGIIHR 155 Query: 195 DVKPHNVMIDHKNKKLRLIDWGLAEFYHVN--------------------------MEYN 228 D+KP N +++ ++ +++ D+GLA + + + Sbjct: 156 DLKPANCLLN-QDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPHNKNLKKQLT 214 Query: 229 VRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI----------FKREPFFHGT--- 275 V +R+++ PEL++ Y S+D+WS G + A ++ R P F G+ Sbjct: 215 SHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNRFPLFPGSSCF 274 Query: 276 --------------SNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 SN DQL I V+GT E + + + P Sbjct: 275 PLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEED------LKCITKQEVIKYIKLFPTRD 328 Query: 322 FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 I+ K+ S + E IDL++++LR++ Q+R+T +A+ HP+ +R++ Sbjct: 329 GIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKE 376 >4CFF-A nrPDB Length = 571 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 69/337 (20%), Positives = 126/337 (37%), Gaps = 77/337 (22%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSN 91 D Y + + +G G + +V G + K+ +K+L K + + Sbjct: 27 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSL------------ 74 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 DV+ I+ I + H +II L+ +I P +V Sbjct: 75 ---------------------DVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDF--FMV 111 Query: 152 FEYVDNV---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK 208 EYV D+ + ++ ++E R ++L A+DYCH ++HRD+KP NV++D + Sbjct: 112 MEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDA-HM 170 Query: 209 KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 268 ++ D+GL+ S + PE++ +D+WS G +L +++ Sbjct: 171 NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGT 230 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 PF + L K ++ G +YL + T Sbjct: 231 LPF--DDEHVPTLFKKIRG-GVFYIPEYLNRSVAT------------------------- 262 Query: 329 HLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 L+ ++L+ D +R T K+ H WF Sbjct: 263 ----------LLMHMLQVDPLKRATIKDIREHEWFKQ 289 >3ZDU-A nrPDB Length = 325 Score = 226 bits (575), Expect = 1e-59, Method: Composition-based stats. Identities = 75/333 (22%), Positives = 140/333 (42%), Gaps = 49/333 (14%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVP 95 + + YE KVG G Y V + ++ + IK+ Sbjct: 1 SMEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKI------------------------- 35 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 +Y ++ V K I H N+++L ++ + K LVFE++ Sbjct: 36 ----------FYERPEQSVNKIAMREIKFLKQFHHENLVNLIEVFRQ--KKKIHLVFEFI 83 Query: 156 DN---VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRL 212 D+ + + L +R Y+F++L+A+DY HS I+HRD+KP N+++ +L Sbjct: 84 DHTVLDELQHYCHGLESKRLRKYLFQILRAIDYLHSNNIIHRDIKPENILVSQSGIT-KL 142 Query: 213 IDWGLAEFY-HVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 D+G A Y+ VA+R+++ PEL++ Y +D+W+ G M+ M P+ Sbjct: 143 CDFGFARTLAAPGDIYDDEVATRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATG-NPY 201 Query: 272 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLS 331 +S+ D L KIV +G L + + + + N K+ Sbjct: 202 LPSSSDLDLLHKIVLKVGN------LSPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPK 255 Query: 332 GNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 N + D++ L+ D +R+++ + + H +F Sbjct: 256 LNGLLADIVHACLQIDPADRISSSDLLHHEYFT 288 >4NIF-A nrPDB Length = 333 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 76/336 (22%), Positives = 131/336 (38%), Gaps = 80/336 (23%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 Y ++ +G G YSE + V + ++ +K++ K+ EI+IL Sbjct: 10 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDP-SEEIEILLR----------- 57 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVD 159 + H NII L D+ D K LV E + + Sbjct: 58 ---------------------------YGQHPNIITLKDVYDD--GKHVYLVTELMRGGE 88 Query: 160 FRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK---LRLI 213 + ++ E F + + K ++Y HS G++HRD+KP N++ ++ LR+ Sbjct: 89 LLDKILRQKFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRIC 148 Query: 214 DWGLAEFYH-VNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFF 272 D+G A+ N + F PE+L + YD D+WS G +L +M+ PF Sbjct: 149 DFGFAKQLRAENGLLMTPCYTANFVAPEVL-KRQGYDEGCDIWSLGILLYTMLAGYTPFA 207 Query: 273 HGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSG 332 +G S D +I+ +G+ +F G + Sbjct: 208 NGPS--DTPEEILTRIGSG-----------------------------KFTLSGGNWNTV 236 Query: 333 NDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 368 ++ DL+ +L D +RLTAK+ + HPW + Sbjct: 237 SETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDK 272 >5XZW-A nrPDB Length = 471 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 74/347 (21%), Positives = 128/347 (36%), Gaps = 96/347 (27%) Query: 38 KDYEI-ENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK----KKIKREIKILTDLSNE 92 KD+ I + VG+G ++ V + ++ + +K++ K + RE+++L L+ Sbjct: 195 KDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLN-- 252 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF 152 H I+ L +D S +V Sbjct: 253 -------------------------------------HPRIVRLKGFYEDTESY--YMVM 273 Query: 153 EYVDNVDFRIL---YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 E+V D + + + R ++L A+ Y HSMGI HRD+KP N++I+ + Sbjct: 274 EFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPV 333 Query: 210 -LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRM------------YDYSLDLWS 256 +++ D+GLA+ + + PE++ Y +D+WS Sbjct: 334 LVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWS 393 Query: 257 FGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIR 316 G ++ ++ PF S DQL K Q R Sbjct: 394 MGCLVYVILTGHLPF--SGSTQDQLYK-----------------------------QIGR 422 Query: 317 KPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 +H K ++E D ID+LL+ D R TA +A+ HPW Sbjct: 423 GSYHEGP---LKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWI 466 >5EZV-A nrPDB Length = 560 Score = 224 bits (572), Expect = 3e-59, Method: Composition-based stats. Identities = 69/337 (20%), Positives = 126/337 (37%), Gaps = 77/337 (22%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSN 91 D Y + + +G G + +V G + K+ +K+L K + + Sbjct: 22 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSL------------ 69 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 DV+ I+ I + H +II L+ +I P +V Sbjct: 70 ---------------------DVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDF--FMV 106 Query: 152 FEYVDNV---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK 208 EYV D+ + ++ ++E R ++L A+DYCH ++HRD+KP NV++D + Sbjct: 107 MEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDA-HM 165 Query: 209 KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 268 ++ D+GL+ S + PE++ +D+WS G +L +++ Sbjct: 166 NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGT 225 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 PF + L K ++ G +YL + T Sbjct: 226 LPF--DDEHVPTLFKKIRG-GVFYIPEYLNRSVAT------------------------- 257 Query: 329 HLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 L+ ++L+ D +R T K+ H WF Sbjct: 258 ----------LLMHMLQVDPLKRATIKDIREHEWFKQ 284 >3MN3-A nrPDB Length = 271 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 66/328 (20%), Positives = 122/328 (37%), Gaps = 76/328 (23%) Query: 39 DYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTT 98 +Y+I +G G + +V + K+ +K++ K+L Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINK----------KVL------------ 42 Query: 99 LPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV--D 156 K D+ I I H +II L+D+IK +V EY + Sbjct: 43 -----------AKSDMQGRIEREISYLRLLRHPHIIKLYDVIKSKDE--IIMVIEYAGNE 89 Query: 157 NVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWG 216 D+ + K+++ E R + +++ A++YCH I+HRD+KP N+++D ++ +++ D+G Sbjct: 90 LFDYIVQRDKMSEQEARRFFQQIISAVEYCHRHKIVHRDLKPENLLLD-EHLNVKIADFG 148 Query: 217 LAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTS 276 L+ S + PE++ +D+WS G +L M+ +R PF + Sbjct: 149 LSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDES- 207 Query: 277 NTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEI 336 K + TLP+ + Sbjct: 208 -------------IPVLFKNISNGVYTLPKFL------------------------SPGA 230 Query: 337 IDLIDNLLRYDHQERLTAKEAMGHPWFA 364 LI +L + R++ E M WF Sbjct: 231 AGLIKRMLIVNPLNRISIHEIMQDDWFK 258 >4CFH-A nrPDB Length = 493 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 71/337 (21%), Positives = 125/337 (37%), Gaps = 77/337 (22%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSN 91 D Y + + +G G + +V G + K+ +K+L K + + Sbjct: 27 DGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSL------------ 74 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 DV+ IR I + H +II L+ +I P +V Sbjct: 75 ---------------------DVVGKIRREIQNLKLFRHPHIIKLYQVISTPSD--IFMV 111 Query: 152 FEYVDNV---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK 208 EYV D+ +L + E R ++L +DYCH ++HRD+KP NV++D + Sbjct: 112 MEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDA-HM 170 Query: 209 KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 268 ++ D+GL+ S + PE++ +D+WS G +L +++ Sbjct: 171 NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGT 230 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 PF + D + + K + F QY+ Sbjct: 231 LPF-----DDDHVPTLFKKICDGIFY----------------TPQYL------------- 256 Query: 329 HLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 N +I L+ ++L+ D +R T K+ H WF Sbjct: 257 ----NPSVISLLKHMLQVDPMKRATIKDIREHEWFKQ 289 >3RP9-A nrPDB Length = 458 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 87/405 (21%), Positives = 153/405 (37%), Gaps = 117/405 (28%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML-----KPVKKKKIKREIKIL 86 DW YEI + +G G Y V + K + IK + + K+I REI IL Sbjct: 48 DWQIP-DRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAIL 106 Query: 87 TDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISK 146 L+ H +++ + DI+ + Sbjct: 107 NRLN---------------------------------------HDHVVKVLDIVIPKDVE 127 Query: 147 T---PALVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHN 200 +V E D+ DF+ L+ LT+L I+ ++ LL + Y HS GI+HRD+KP N Sbjct: 128 KFDELYVVLEIADS-DFKKLFRTPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPAN 186 Query: 201 VMIDHKNKKLRLIDWGLAEFY----------------------------HVNMEYNVRVA 232 +++ ++ +++ D+GLA ++ + V Sbjct: 187 CLVN-QDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLKRQLTGHVV 245 Query: 233 SRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI----------FKREPFFHGTS------ 276 +R+++ PEL++ Y ++D+WS G + A ++ R P F G+S Sbjct: 246 TRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYHADRGPLFPGSSCFPLSP 305 Query: 277 --------------NTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 N DQL I +LGT E + R P Sbjct: 306 DQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDAKRYIRIF------PKREG 359 Query: 323 INDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIR 367 + + + + + I L+ +L ++ +R+T E + HP+F +R Sbjct: 360 TDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKEVR 404 >4RED-A nrPDB Length = 351 Score = 224 bits (570), Expect = 6e-59, Method: Composition-based stats. Identities = 69/335 (20%), Positives = 124/335 (37%), Gaps = 77/335 (22%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 93 S Y + + +G G + +V G + + +K+L K + + Sbjct: 10 SVKIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSL-------------- 55 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 DV+ IR I + H +II L+ +I P +V E Sbjct: 56 -------------------DVVGKIRREIQNLKLFRHPHIIKLYQVISTPSD--IFMVME 94 Query: 154 YVDNV---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 YV D+ +L + E R ++L +DYCH ++HRD+KP NV++D + Sbjct: 95 YVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDA-HMNA 153 Query: 211 RLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 ++ D+GL+ S + PE++ +D+WS G +L +++ P Sbjct: 154 KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLP 213 Query: 271 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 330 F + D + + K + F QY+ Sbjct: 214 F-----DDDHVPTLFKKICDGIFY----------------TPQYL--------------- 237 Query: 331 SGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 N +I L+ ++L+ D +R + K+ H WF Sbjct: 238 --NPSVISLLKHMLQVDPMKRASIKDIREHEWFKQ 270 >2YAB-A nrPDB Length = 361 Score = 223 bits (568), Expect = 9e-59, Method: Composition-based stats. Identities = 73/338 (21%), Positives = 129/338 (38%), Gaps = 73/338 (21%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 Y+I ++G G+++ V + + + ++ K +K + + +R Sbjct: 12 DFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRR---------------- 55 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 ++E I + H NII L D+ ++ L+ E V Sbjct: 56 ---------GVCREE-----IEREVSILRQVLHPNIITLHDVYENRTD--VVLILELVSG 99 Query: 158 V---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN---KKLR 211 DF L++ E ++ ++L ++Y H+ I H D+KP N+M+ KN ++ Sbjct: 100 GELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIK 159 Query: 212 LIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 LID+GLA +E+ + F PE +V+Y D+WS G + ++ PF Sbjct: 160 LIDFGLAHEIEDGVEFKNIFGTPEFVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPF 218 Query: 272 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLS 331 G + + L I V D E Sbjct: 219 L-GDTKQETLANITAVSYDFDEEF---------------------------------FSQ 244 Query: 332 GNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 ++ D I LL + ++RLT +EA+ HPW P+ Q Sbjct: 245 TSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDTQ 282 >5YKS-A nrPDB Length = 377 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 61/339 (17%), Positives = 123/339 (36%), Gaps = 88/339 (25%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKI-----KREIKILTDLSNEKV 94 Y+++ +GRG ++ V + + K+ +K++ K + +E++ + + Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQ---- 92 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 H NI+ L+++I L+ E Sbjct: 93 -----------------------------------HPNIVRLYEVIDTQTK--LYLILEL 115 Query: 155 VDNVDFRILYPK----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 D D K L + + Y +++ A+ YCH + ++HRD+KP NV+ K + Sbjct: 116 GDGGDMFDYIMKHEEGLNEDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLV 175 Query: 211 RLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 +L D+G + + + S + PE+L+ ++D+WS G +L ++ + P Sbjct: 176 KLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILFMLVCGQPP 235 Query: 271 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 330 F ++++ L I+ T Sbjct: 236 F-QEANDSETLTMIMDCKYTVPSH------------------------------------ 258 Query: 331 SGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 + E DLI +L+ D + R + +E HPW + Sbjct: 259 -VSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPS 296 >2J90-A nrPDB Length = 304 Score = 223 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 74/347 (21%), Positives = 129/347 (37%), Gaps = 91/347 (26%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP---------VKKKKIKREIKILTD 88 YE+ ++G G+++ V + + + + K +K V +++I+RE+ IL + Sbjct: 26 DHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILRE 85 Query: 89 LSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTP 148 + H NII L DI ++ Sbjct: 86 IR---------------------------------------HPNIITLHDIFENKTD--V 104 Query: 149 ALVFEYVDNV---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI-- 203 L+ E V DF LT+ E ++ ++L + Y HS I H D+KP N+M+ Sbjct: 105 VLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLD 164 Query: 204 -DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLA 262 + N +++LID+G+A E+ + F PE +V+Y D+WS G + Sbjct: 165 KNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPE-IVNYEPLGLEADMWSIGVITY 223 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 ++ PF G + + L I V D E Sbjct: 224 ILLSGASPFL-GETKQETLTNISAVNYDFDEEY--------------------------- 255 Query: 323 INDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 + ++ D I LL D + R+T +++ H W IR + Sbjct: 256 ------FSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRR 296 >4RGJ-A nrPDB Length = 520 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 63/337 (18%), Positives = 135/337 (40%), Gaps = 85/337 (25%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML------KPVKKKKIKREIKILTDLSN 91 + Y+ +G+G + EV + + IK++ + K+ + RE+++L L Sbjct: 60 EQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLD- 118 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL- 150 H NI+ L++ +D Sbjct: 119 --------------------------------------HINIMKLYEFFEDNNYYYLVSD 140 Query: 151 VFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK- 209 V+ + D I + +++ + ++L + Y H ++HRD+KP N++++ KNK+ Sbjct: 141 VYTGGELFDEIISRKRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPENILLETKNKED 200 Query: 210 --LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 +++ID+GL+ + + + ++ + ++ P++L + YD D+WS G +L ++ Sbjct: 201 MIIKIIDFGLSTHFEYSKKMKDKIGTAYYIAPDVL--HGTYDEKCDIWSCGVILYILLSG 258 Query: 268 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGN 327 PF +G++ D L K+ ++ D Sbjct: 259 CPPF-NGSNEYDILKKVEAG---------------------------------KYTFDLP 284 Query: 328 KHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + +D+ DLI +L Y R++A++A+ H W Sbjct: 285 QFKKISDKAKDLIKKMLMYTSAVRISARDALEHEWIK 321 >5WAX-A nrPDB Length = 310 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 63/332 (18%), Positives = 116/332 (34%), Gaps = 75/332 (22%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVP 95 + YE+ +G G + + +K Sbjct: 9 DGDRYELVRDIGSGNFGVARLMRNRADGQLVAVK-------------------------- 42 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 Y + E + + ++ I + H NII ++I P A+V EY Sbjct: 43 -----------YIERGEKIDENVQREIINHRSLRHPNIIRFKEVILTPTH--LAIVMEYA 89 Query: 156 DNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK-KLR 211 + + ++ E RF+ +L+ + YCHSM + HRD+K N ++D +L+ Sbjct: 90 SGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSMQVCHRDLKLENTLLDGSTAPRLK 149 Query: 212 LIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 + D+G ++ ++ + V + + PE+L+ D+WS G L M+ PF Sbjct: 150 ICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPF 209 Query: 272 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLS 331 + I ++LG + ++P + Sbjct: 210 EDPDEPKNFRKTIQRILG----------VQYSIPDYVH---------------------- 237 Query: 332 GNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + E DLI + + R+T E HPWF Sbjct: 238 ISPECQDLISRIFVANPATRITIPEIRNHPWF 269 >4BGQ-A nrPDB Length = 304 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 93/352 (26%), Positives = 147/352 (41%), Gaps = 63/352 (17%) Query: 28 NTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVK-----KKKIKRE 82 + + +EI VG G Y V + ++ + IK K + K+ RE Sbjct: 2 MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRE 61 Query: 83 IKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD 142 +K+L L E NI+ L + + Sbjct: 62 LKMLRTLKQE---------------------------------------NIVELKEAFRR 82 Query: 143 PISKTPALVFEYVDNVDFRILYP---KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPH 199 LVFEYV+ +L + +++ Y+++L+KA+ +CH I+HRD+KP Sbjct: 83 --RGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPE 140 Query: 200 NVMIDHKNKKLRLIDWGLAEFYHVNM--EYNVRVASRFFKGPELLVDYRMYDYSLDLWSF 257 N++I H N L+L D+G A Y+ VA+R+++ PELL+ Y S+D+WS Sbjct: 141 NLLISH-NDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGA-PYGKSVDMWSV 198 Query: 258 GTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRK 317 G +L + + P F G S DQL I KVLG E+ L Y +R Sbjct: 199 GCILGELSDGQ-PLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNP-------RFHGLRF 250 Query: 318 PWHRFINDGNKHLSG--NDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIR 367 P + G N ++DL+ NLL+ D +R ++ + HP F R Sbjct: 251 PAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQR 302 >3H4J-B nrPDB Length = 336 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 65/326 (19%), Positives = 117/326 (35%), Gaps = 76/326 (23%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 Y I +G G + +V ++ K+ +K + ++L Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISR----------QLLKKSDMHM------ 54 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV--DN 157 + I H +II L+D+I P +V EY + Sbjct: 55 -----------------RVEREISYLKLLRHPHIIKLYDVITTPTD--IVMVIEYAGGEL 95 Query: 158 VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGL 217 D+ + ++T+ E R + +++ A++YCH I+HRD+KP N+++D N +++ D+GL Sbjct: 96 FDYIVEKKRMTEDEGRRFFQQIICAIEYCHRHKIVHRDLKPENLLLD-DNLNVKIADFGL 154 Query: 218 AEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSN 277 + S + PE++ +D+WS G +L M+ R PF Sbjct: 155 SNIMTDGNFLKTSCGSPNYAAPEVINGKLYAGPEVDVWSCGIVLYVMLVGRLPF--DDEF 212 Query: 278 TDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEII 337 L K V Y M ++ + Sbjct: 213 IPNLFKKVNSC-------------------VYVMPDFL-----------------SPGAQ 236 Query: 338 DLIDNLLRYDHQERLTAKEAMGHPWF 363 LI ++ D +R+T +E PWF Sbjct: 237 SLIRRMIVADPMQRITIQEIRRDPWF 262 >2YCR-A nrPDB Length = 323 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 61/336 (18%), Positives = 120/336 (35%), Gaps = 71/336 (21%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPP 96 +Y + +G G EV + + K+ IK++ K Sbjct: 9 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFA------------------- 49 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 + ++ D + I H II + + ++ +V E ++ Sbjct: 50 ---------IGSAREADPALNVETEIEILKKLNHPCIIKIKNFF---DAEDYYIVLELME 97 Query: 157 NVDFRIL---YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID--HKNKKLR 211 + +L + + Y +++L A+ Y H GI+HRD+KP NV++ ++ ++ Sbjct: 98 GGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIK 157 Query: 212 LIDWGLAEFYHVNMEYNVRVASRFFKGPELL--VDYRMYDYSLDLWSFGTMLASMIFKRE 269 + D+G ++ + + PE+L V Y+ ++D WS G +L + Sbjct: 158 ITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYP 217 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 PF R + I + FI + Sbjct: 218 PFSEH-------------------------------RTQVSLKDQITSGKYNFIPEVWAE 246 Query: 330 LSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 + +++ +DL+ LL D + R T +EA+ HPW Sbjct: 247 V--SEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 280 >4FG9-A nrPDB Length = 320 Score = 221 bits (564), Expect = 3e-58, Method: Composition-based stats. Identities = 61/333 (18%), Positives = 118/333 (35%), Gaps = 77/333 (23%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPP 96 Y+ + +G G +SEV ++ + IK + Sbjct: 17 RDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCI------------------------- 51 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 E + I H NI+ L DI + L+ + V Sbjct: 52 ----------AKEALEGKEGSMENEIAVLHKIKHPNIVALDDIYES--GGHLYLIMQLVS 99 Query: 157 NVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH--KNKKLR 211 + + T+ + +F++L A+ Y H +GI+HRD+KP N++ ++ K+ Sbjct: 100 GGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIM 159 Query: 212 LIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 + D+GL++ + + + PE+L + Y ++D WS G + ++ PF Sbjct: 160 ISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQ-KPYSKAVDCWSIGVIAYILLCGYPPF 218 Query: 272 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLS 331 + ++ +I+K D + Sbjct: 219 YD-ENDAKLFEQILKAEYEFDSPYWD---------------------------------D 244 Query: 332 GNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 +D D I +L+ D ++R T ++A+ HPW A Sbjct: 245 ISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIA 277 >4JG6-A nrPDB Length = 355 Score = 221 bits (562), Expect = 4e-58, Method: Composition-based stats. Identities = 73/334 (21%), Positives = 130/334 (38%), Gaps = 80/334 (23%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPP 96 T YE++ +G G YS + + + ++ +K++ K+ EI+IL Sbjct: 34 TDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPT-EEIEILLR-------- 84 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 + H NII L D+ D K +V E + Sbjct: 85 ------------------------------YGQHPNIITLKDVYDD--GKYVYVVTELMK 112 Query: 157 NVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK---L 210 + + ++ E +F + K ++Y H+ G++HRD+KP N++ ++ + Sbjct: 113 GGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESI 172 Query: 211 RLIDWGLAEFYH-VNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 R+ D+G A+ N + F PE+L + + YD + D+WS G +L +M+ Sbjct: 173 RICDFGFAKQLRAENGLLMTPCYTANFVAPEVL-ERQGYDAACDIWSLGVLLYTMLTGYT 231 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 PF +G D +I+ +G+ +F G Sbjct: 232 PFANGPD--DTPEEILARIGSG-----------------------------KFSLSGGYW 260 Query: 330 LSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 S +D DL+ +L D +RLTA + HPW Sbjct: 261 NSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 294 >5KZ7-A nrPDB Length = 346 Score = 220 bits (561), Expect = 6e-58, Method: Composition-based stats. Identities = 61/321 (19%), Positives = 137/321 (42%), Gaps = 57/321 (17%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKM-----LKPVKKKKIKREIKIL 86 D + +Y + +G+G +++V + + ++ +K+ L +K+ RE++I+ Sbjct: 27 DEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIM 86 Query: 87 TDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISK 146 L+ H NI+ LF++I+ K Sbjct: 87 KVLN---------------------------------------HPNIVKLFEVIE--TEK 105 Query: 147 TPALVFEYVDNV---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI 203 T LV EY D+ + + ++ + E R +++ A+ YCH I+HRD+K N+++ Sbjct: 106 TLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLL 165 Query: 204 DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLAS 263 D + +++ D+G + + + + S + PEL + +D+WS G +L + Sbjct: 166 DA-DMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYT 224 Query: 264 MIFKREPFFHGTSNTDQLVKIVKV------LGTSDFEKYLLKYEITLPREFYDMDQYIRK 317 ++ PF G + + ++++ ++D E L K+ I P + ++Q ++ Sbjct: 225 LVSGSLPF-DGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKD 283 Query: 318 PWHRFINDGNKHLSGNDEIID 338 W ++ ++ + + D Sbjct: 284 RWMNVGHEDDELKPYVEPLPD 304 >2A27-A nrPDB Length = 321 Score = 220 bits (560), Expect = 8e-58, Method: Composition-based stats. Identities = 71/338 (21%), Positives = 128/338 (37%), Gaps = 73/338 (21%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 Y+I ++G G+++ V + + + ++ K +K + + +R + Sbjct: 12 DFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVS------------- 58 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 + I + H N+I L D+ ++ L+ E V Sbjct: 59 -----------------REEIEREVSILRQVLHHNVITLHDVYENRTD--VVLILELVSG 99 Query: 158 V---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN---KKLR 211 DF L++ E ++ ++L ++Y H+ I H D+KP N+M+ KN ++ Sbjct: 100 GELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIK 159 Query: 212 LIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 LID+GLA +E+ + F PE +V+Y D+WS G + ++ PF Sbjct: 160 LIDFGLAHEIEDGVEFKNIFGTPEFVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPF 218 Query: 272 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLS 331 G + + L I V D E Sbjct: 219 L-GDTKQETLANITAVSYDFDEEF---------------------------------FSQ 244 Query: 332 GNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 ++ D I LL + ++RLT +EA+ HPW P+ Q Sbjct: 245 TSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQ 282 >3I6U-A nrPDB Length = 419 Score = 220 bits (560), Expect = 9e-58, Method: Composition-based stats. Identities = 60/336 (17%), Positives = 120/336 (35%), Gaps = 71/336 (21%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPP 96 +Y + +G G EV + + K+ I+++ K Sbjct: 134 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFA------------------- 174 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 + ++ D + I H II + + ++ +V E ++ Sbjct: 175 ---------IGSAREADPALNVETEIEILKKLNHPCIIKIKNFF---DAEDYYIVLELME 222 Query: 157 NVDFRIL---YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID--HKNKKLR 211 + +L + + Y +++L A+ Y H GI+HRD+KP NV++ ++ ++ Sbjct: 223 GGELFDKVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIK 282 Query: 212 LIDWGLAEFYHVNMEYNVRVASRFFKGPELL--VDYRMYDYSLDLWSFGTMLASMIFKRE 269 + D+G ++ + + PE+L V Y+ ++D WS G +L + Sbjct: 283 ITDFGHSKILGETSLMRTLCGTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYP 342 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 PF R + I + FI + Sbjct: 343 PFSEH-------------------------------RTQVSLKDQITSGKYNFIPEVWAE 371 Query: 330 LSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 + +++ +DL+ LL D + R T +EA+ HPW Sbjct: 372 V--SEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 405 >2YZA-A nrPDB Length = 276 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 69/337 (20%), Positives = 126/337 (37%), Gaps = 77/337 (22%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSN 91 D Y + + +G G + +V G + K+ +K+L K + + Sbjct: 5 DGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSL------------ 52 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 DV+ I+ I + H +II L+ +I P +V Sbjct: 53 ---------------------DVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDF--FMV 89 Query: 152 FEYVDNV---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK 208 EYV D+ + ++ ++E R ++L A+DYCH ++HRD+KP NV++D + Sbjct: 90 MEYVSGGELFDYICKHGRVEEMEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDA-HM 148 Query: 209 KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 268 ++ D+GL+ S + PE++ +D+WS G +L +++ Sbjct: 149 NAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGT 208 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 PF + L K ++ G +YL + T Sbjct: 209 LPF--DDEHVPTLFKKIRG-GVFYIPEYLNRSVAT------------------------- 240 Query: 329 HLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 L+ ++L+ D +R T K+ H WF Sbjct: 241 ----------LLMHMLQVDPLKRATIKDIREHEWFKQ 267 >2JAM-A nrPDB Length = 304 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 65/336 (19%), Positives = 124/336 (36%), Gaps = 85/336 (25%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK---IKREIKILTDLSNEK 93 K + +G G +SEVF + + +K +K + ++ EI +L + Sbjct: 8 RKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIK--- 64 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 H NI+ L DI + LV + Sbjct: 65 ------------------------------------HENIVTLEDIYESTTHY--YLVMQ 86 Query: 154 YVDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI--DHKNK 208 V + + T+ + + ++L A+ Y H GI+HRD+KP N++ +N Sbjct: 87 LVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENS 146 Query: 209 KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 268 K+ + D+GL++ N + + + PE+L + Y ++D WS G + ++ Sbjct: 147 KIMITDFGLSK-MEQNGIMSTACGTPGYVAPEVLAQ-KPYSKAVDCWSIGVITYILLCGY 204 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 PF+ T + + + I++ ++ F + Sbjct: 205 PPFYEETESK--------------------------------LFEKIKEGYYEFESPFWD 232 Query: 329 HLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + ++ D I +LL D ER T ++A+ HPW Sbjct: 233 DI--SESAKDFICHLLEKDPNERYTCEKALSHPWID 266 >3D2K-A nrPDB Length = 272 Score = 219 bits (557), Expect = 2e-57, Method: Composition-based stats. Identities = 74/343 (21%), Positives = 129/343 (37%), Gaps = 81/343 (23%) Query: 25 DYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIK 84 + W+ +D++I +G+GK+ V+ + SK + +K+L + +K E Sbjct: 1 GPLGSKRQWTL--EDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVE-- 56 Query: 85 ILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI 144 +R + Q H H NI+ L+ D Sbjct: 57 -------------------------------HQLRREVEIQSHLRHPNILRLYGYFHDAT 85 Query: 145 SKTPALVFEYVDNVDFRILYPKLT---DLEIRFYMFELLKALDYCHSMGIMHRDVKPHNV 201 L+ EY KL+ + Y+ EL AL YCHS ++HRD+KP N+ Sbjct: 86 R--VYLILEYAPLGTVYRELQKLSRFDEQRTATYITELANALSYCHSKRVIHRDIKPENL 143 Query: 202 MIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTML 261 ++ N +L++ D+G + + + + + PE++ + RM+D +DLWS G + Sbjct: 144 LLGS-NGELKIADFGWS-VHAPSSRRTTLCGTLDYLPPEMI-EGRMHDEKVDLWSLGVLC 200 Query: 262 ASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 + PF + + +I +V E T P Sbjct: 201 YEFLVGMPPF-EAHTYQETYRRISRV-------------EFTFPD--------------- 231 Query: 322 FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + DLI LL+++ +RLT E + HPW Sbjct: 232 ---------FVTEGARDLISRLLKHNASQRLTLAEVLEHPWIK 265 >1ZWS-A nrPDB Length = 288 Score = 218 bits (556), Expect = 2e-57, Method: Composition-based stats. Identities = 71/338 (21%), Positives = 128/338 (37%), Gaps = 73/338 (21%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 Y+I ++G G+++ V + + + ++ K +K + + +R + Sbjct: 12 DFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVS------------- 58 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 + I + H N+I L D+ ++ L+ E V Sbjct: 59 -----------------REEIEREVSILRQVLHHNVITLHDVYENRTD--VVLILELVSG 99 Query: 158 V---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN---KKLR 211 DF L++ E ++ ++L ++Y H+ I H D+KP N+M+ KN ++ Sbjct: 100 GELFDFLAQKESLSEEEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIK 159 Query: 212 LIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 LID+GLA +E+ + F PE +V+Y D+WS G + ++ PF Sbjct: 160 LIDFGLAHEIEDGVEFKNIFGTPEFVAPE-IVNYEPLGLEADMWSIGVITYILLSGASPF 218 Query: 272 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLS 331 G + + L I V D E Sbjct: 219 L-GDTKQETLANITSVSYDFDEEF---------------------------------FSH 244 Query: 332 GNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 ++ D I LL + ++RLT +EA+ HPW P+ Q Sbjct: 245 TSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDNQ 282 >4UZD-A nrPDB Length = 287 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 71/330 (21%), Positives = 125/330 (37%), Gaps = 79/330 (23%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 +D+EI +G+GK+ V+ + SK + +K+L + +K E Sbjct: 8 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVE--------------- 52 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 +R + Q H H NI+ L+ D L+ EY Sbjct: 53 ------------------HQLRREVEIQSHLRHPNILRLYGYFHDATR--VYLILEYAPL 92 Query: 158 VDFRILYPKLT---DLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLID 214 KL+ + Y+ EL AL YCHS ++HRD+KP N+++ +L++ D Sbjct: 93 GTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAG-ELKIAD 151 Query: 215 WGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHG 274 +G + + + + + PE++ + RM+D +DLWS G + + + PF Sbjct: 152 FGWS-VHAPSSRRTTLCGTLDYLPPEMI-EGRMHDEKVDLWSLGVLCYEFLVGKPPF-EA 208 Query: 275 TSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGND 334 + + +I +V E T P + Sbjct: 209 NTYQETYKRISRV-------------EFTFPD------------------------FVTE 231 Query: 335 EIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 DLI LL+++ +R +E + HPW Sbjct: 232 GARDLISRLLKHNPSQRPMLREVLEHPWIT 261 >4PDS-A nrPDB Length = 347 Score = 218 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 73/348 (20%), Positives = 127/348 (36%), Gaps = 96/348 (27%) Query: 38 KDYEI-ENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK----KKIKREIKILTDLSNE 92 KD+ I + VG+G ++ V + ++ + +K++ K + RE+++L L+ Sbjct: 30 KDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKLN-- 87 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF 152 H I+ L +D S +V Sbjct: 88 -------------------------------------HPRIVRLKGFYEDTESY--YMVM 108 Query: 153 EYVDNVDFRIL---YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 E+V D + + + R ++L A+ Y HSMGI HRD+KP N++I+ + Sbjct: 109 EFVSGGDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMGISHRDLKPDNILIEQDDPV 168 Query: 210 -LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRM------------YDYSLDLWS 256 +++ +GLA+ + + PE++ Y +D+WS Sbjct: 169 LVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWS 228 Query: 257 FGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIR 316 G ++ ++ PF S DQL K Q R Sbjct: 229 MGCLVYVILTGHLPF--SGSTQDQLYK-----------------------------QIGR 257 Query: 317 KPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 +H K ++E D ID+LL+ D R TA +A+ HPW Sbjct: 258 GSYHEGP---LKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIK 302 >4CZT-A nrPDB Length = 464 Score = 216 bits (551), Expect = 1e-56, Method: Composition-based stats. Identities = 70/343 (20%), Positives = 123/343 (35%), Gaps = 92/343 (26%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKM------LKPVKKKKIKREIKILT 87 T YE+ +G G +++V +++ + IK+ LK +IKREI + Sbjct: 7 RTRVGKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMK 66 Query: 88 DLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKT 147 + H N+I +F+++ Sbjct: 67 LIK---------------------------------------HPNVIRMFEVMASKTK-- 85 Query: 148 PALVFEYVDNVDFRILY---PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID 204 V E+V + +L + E R Y +L+ A+DYCHS G+ HRD+KP N+++D Sbjct: 86 IYFVLEFVTGGELFDKISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHRDLKPENLLLD 145 Query: 205 HKNKKLRLIDWGLA---EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTML 261 N L++ D+GL+ + + + + + PE++ + DLWS G +L Sbjct: 146 A-NGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGYDGAKADLWSCGVIL 204 Query: 262 ASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 ++ PF + K + K E T P F Sbjct: 205 FVLMAGYLPFEDSN--------------LTSLYKKIFKAEFTCPPWF------------- 237 Query: 322 FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + LI +L + R+T E + + WF Sbjct: 238 -----------SASAKKLIKRILDPNPATRITFAEVIENEWFK 269 >5ZTN-A nrPDB Length = 429 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 71/356 (19%), Positives = 139/356 (39%), Gaps = 74/356 (20%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK--KKIKREIKILTDLSNEKVPPT 97 YE+ +G+G + +V + + +KM++ K+ ++ EI+IL L + T Sbjct: 99 YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNT 158 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 N+IH+ + + FE + Sbjct: 159 M---------------------------------NVIHMLENFT--FRNHICMTFELLSM 183 Query: 158 VDFRILYPK----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK-LRL 212 + ++ + +R + +L+ LD H I+H D+KP N+++ + + +++ Sbjct: 184 NLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKV 243 Query: 213 IDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFF 272 ID+G + + H + SRF++ PE+++ R Y +D+WS G +LA ++ P Sbjct: 244 IDFGSSCYEH--QRVYTYIQSRFYRAPEVILGAR-YGMPIDMWSLGCILAELLTGY-PLL 299 Query: 273 HGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSG 332 G DQL ++++LG L + F Y R ++DG+ L+G Sbjct: 300 PGEDEGDQLACMIELLGMPSQ---KLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNG 356 Query: 333 -------------------------NDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + +D + L +D R+T +A+ HPW Sbjct: 357 GRSRRGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL 412 >2I6L-A nrPDB Length = 320 Score = 214 bits (546), Expect = 3e-56, Method: Composition-based stats. Identities = 70/330 (21%), Positives = 137/330 (41%), Gaps = 43/330 (13%) Query: 43 ENKVGRGKYSEVFQGVKLDSKVKIVIKML---KPVKKKKIKREIKILTDLSNEKVPPTTL 99 +G G VF V D ++ IK + P K REIKI+ L ++ + Sbjct: 16 LKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFE 75 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVD 159 L + + +V EY++ Sbjct: 76 ILGPSGSQLTDDVGSLTEL---------------------------NSVYIVQEYMETDL 108 Query: 160 FRILYPK-LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA 218 +L L + R +M++LL+ L Y HS ++HRD+KP N+ I+ ++ L++ D+GLA Sbjct: 109 ANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLA 168 Query: 219 EFYHVNMEYNVR----VASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHG 274 + + + +++++ P LL+ Y ++D+W+ G + A M+ + F G Sbjct: 169 RIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKT-LFAG 227 Query: 275 TSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGND 334 +Q+ I++ + E + +P + KP + + ++ Sbjct: 228 AHELEQMQLILESIPVVHEED-RQELLSVIPVYIRNDMTEPHKPLTQLLPGISR------ 280 Query: 335 EIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 E +D ++ +L + +RLTA+EA+ HP+ + Sbjct: 281 EAVDFLEQILTFSPMDRLTAEEALSHPYMS 310 >1PHK-A nrPDB Length = 298 Score = 214 bits (545), Expect = 4e-56, Method: Composition-based stats. Identities = 65/336 (19%), Positives = 127/336 (37%), Gaps = 71/336 (21%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 ++YE + +GRG S V + + + + +K++ E Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAE--------------- 61 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 +E ++ + +GH NII L D + + LVF+ + Sbjct: 62 -----------EVQELREATLKEVDILRKVSGHPNIIQLKDTYE--TNTFFFLVFDLMKK 108 Query: 158 VDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLID 214 + + L++ E R M LL+ + H + I+HRD+KP N+++D + ++L D Sbjct: 109 GELFDYLTEKVTLSEKETRKIMRALLEVICALHKLNIVHRDLKPENILLD-DDMNIKLTD 167 Query: 215 WGLAEFYHVNMEYNVRVASRFFKGPELLV-----DYRMYDYSLDLWSFGTMLASMIFKRE 269 +G + + + + PE++ ++ Y +D+WS G ++ +++ Sbjct: 168 FGFSCQLDPGEKLREVCGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSP 227 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 PF+H K + L Q+ W + Sbjct: 228 PFWH------------------------RKQMLMLRMIMSGNYQFGSPEWDDY------- 256 Query: 330 LSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 +D + DL+ L Q+R TA+EA+ HP+F Sbjct: 257 ---SDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQQ 289 >3IS5-A nrPDB Length = 285 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 59/339 (17%), Positives = 124/339 (36%), Gaps = 91/339 (26%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK----KKIKREIKILTDLSNEKVP 95 + + K+G G + +V + S ++ VIK + + ++I+ EI++L L Sbjct: 24 FIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEAEIEVLKSLD----- 78 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 H NII +F++ +D +V E Sbjct: 79 ----------------------------------HPNIIKIFEVFED--YHNMYIVMETC 102 Query: 156 DNVDFRILY-------PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI--DHK 206 + + L++ + M +++ AL Y HS ++H+D+KP N++ Sbjct: 103 EGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFHSQHVVHKDLKPENILFQDTSP 162 Query: 207 NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 + +++ID+GLAE + + + + PE+ R + D+WS G ++ ++ Sbjct: 163 HSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEVF--KRDVTFKCDIWSAGVVMYFLLT 220 Query: 267 KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG 326 PF +++ +K ++ N Sbjct: 221 GCLPF-----------------------------------TGTSLEEVQQKATYKEPNYA 245 Query: 327 NKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 + + +DL+ +L D + R +A + + H WF Sbjct: 246 VECRPLTPQAVDLLKQMLTKDPERRPSAAQVLHHEWFKQ 284 >3UC3-A nrPDB Length = 361 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 59/332 (17%), Positives = 110/332 (33%), Gaps = 75/332 (22%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVP 95 ++ Y+ +G G + +K + +K Sbjct: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVK-------------------------- 51 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 Y + + + ++ I + H NI+ ++I P A++ EY Sbjct: 52 -----------YIERGAAIDENVQREIINHRSLRHPNIVRFKEVILTPTH--LAIIMEYA 98 Query: 156 DNVDFRILY---PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID-HKNKKLR 211 + + ++ E RF+ +LL + YCHSM I HRD+K N ++D +L+ Sbjct: 99 SGGELYERICNAGRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLK 158 Query: 212 LIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 + D+G ++ ++ + V + + PE+L+ D+WS G L M+ PF Sbjct: 159 ICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPF 218 Query: 272 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLS 331 D I ++L + Sbjct: 219 EDPEEPRDYRKTIQRIL--------------------------------SVKYSIPDDIR 246 Query: 332 GNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + E LI + D R++ E H WF Sbjct: 247 ISPECCHLISRIFVADPATRISIPEIKTHSWF 278 >5Y86-A nrPDB Length = 588 Score = 214 bits (544), Expect = 6e-56, Method: Composition-based stats. Identities = 74/354 (20%), Positives = 141/354 (39%), Gaps = 68/354 (19%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK--KKIKREIKILTDLSNEKVPPT 97 YE+ +G+G + +V + + + +KM++ K+ ++ EI+IL L Sbjct: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLK------- 261 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 Q G N+IH+ + + FE + Sbjct: 262 --------------------------KQDKTGSMNVIHMLESFT--FRNHVCMAFELLSI 293 Query: 158 VDFRILYPK----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN-KKLRL 212 + ++ + +R + +L++LD H I+H D+KP N+++ H ++ Sbjct: 294 DLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKV 353 Query: 213 IDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFF 272 ID+G + F + + + SRF++ PE+++ R Y +D+WSFG +LA ++ + P F Sbjct: 354 IDFGSSCFEY--QKLYTYIQSRFYRAPEIILGSR-YSTPIDIWSFGCILAELLTGQ-PLF 409 Query: 273 HGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQY------------------ 314 G DQL ++++LG + + +Y Sbjct: 410 PGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRS 469 Query: 315 --IRKPWHRFINDGNKHLSGNDE--IIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 +K D L G D+ I+ + L +D RLT +A+ HPW + Sbjct: 470 RRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523 >5JZN-A nrPDB Length = 280 Score = 214 bits (544), Expect = 6e-56, Method: Composition-based stats. Identities = 66/336 (19%), Positives = 127/336 (37%), Gaps = 86/336 (25%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKK----KIKREIKILTDLSNE 92 T+ Y++ +G G ++ V + V+ + + +K++K K + I+ E+ IL + Sbjct: 18 TERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVK-- 75 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF 152 H NI+ L + + P LV Sbjct: 76 -------------------------------------HPNIVLLIEEMDVPTE--LYLVM 96 Query: 153 EYVDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI---DHK 206 E V D K T+ + ++ L A+ Y HS+ I+HRD+KP N+++ Sbjct: 97 ELVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDG 156 Query: 207 NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 +K L+L D+GLA + + + PE++ + Y +D+W+ G + ++ Sbjct: 157 SKSLKLGDFGLATIV--DGPLYTVCGTPTYVAPEIIAET-GYGLKVDIWAAGVITYILLC 213 Query: 267 KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG 326 PF + + L +L ++ P ++D Sbjct: 214 GFPPFRGSGDDQEVLF------------DQILMGQVDFPSPYWD---------------- 245 Query: 327 NKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 + +D +LI +L D +R +A + + HPW Sbjct: 246 ----NVSDSAKELITMMLLVDVDQRFSAVQVLEHPW 277 >4D28-A nrPDB Length = 446 Score = 214 bits (544), Expect = 7e-56, Method: Composition-based stats. Identities = 72/348 (20%), Positives = 126/348 (36%), Gaps = 94/348 (27%) Query: 39 DYEIENKVGRGKYSEVFQGVKLDSKVKIVIKM------LKPVKKKKIKREIKILTDLSNE 92 YE+ +G G +++V D+ + IK+ LK +IKREI I+ Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMK----- 64 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF 152 H NI+ L++++ +V Sbjct: 65 ----------------------------------IVRHPNIVRLYEVL--ASKSKIYIVL 88 Query: 153 EYVDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 E+V + + +L + E R Y +L+ A+ +CHS G+ HRD+KP N+++D N Sbjct: 89 EFVTGGELFDRIVHKGRLKEDESRKYFQQLVDAVAHCHSKGVYHRDLKPENLLLDT-NGN 147 Query: 210 LRLIDWGLAEFYHVNME-YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 268 L++ D+GL+ +E N + + PE+L + D+WS G +L ++ Sbjct: 148 LKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVLSGQGYDGSAADIWSCGVILFVILAGY 207 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 PF + + E P F Sbjct: 208 LPFSETD--------------LPGLYRKINAAEFDCPPWF-------------------- 233 Query: 329 HLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA----PIREQIEK 372 + E+ LI +L + + R+ + PWF PIR + E+ Sbjct: 234 ----SAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRKNYVPIRAREEE 277 >3ZUT-A nrPDB Length = 362 Score = 213 bits (543), Expect = 8e-56, Method: Composition-based stats. Identities = 59/332 (17%), Positives = 113/332 (34%), Gaps = 75/332 (22%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVP 95 ++ YE+ +G G + S + +K Sbjct: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVK-------------------------- 50 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 Y + E + + ++ I + H NI+ ++I P A+V EY Sbjct: 51 -----------YIERGEKIDENVKREIINHRSLRHPNIVRFKEVILTPTH--LAIVMEYA 97 Query: 156 DNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID-HKNKKLR 211 + + ++ E RF+ +L+ + YCH+M + HRD+K N ++D +L+ Sbjct: 98 SGGELFERICNAGRFSEDEARFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLK 157 Query: 212 LIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 + +G ++ ++ + V + + PE+L+ D+WS G L M+ PF Sbjct: 158 ICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPF 217 Query: 272 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLS 331 + K K + Y + Y+ Sbjct: 218 ED-----------------PEEPKNFRKTIHRILNVQYAIPDYVH--------------- 245 Query: 332 GNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + E LI + D +R++ E H WF Sbjct: 246 ISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 >3GUB-A nrPDB Length = 295 Score = 213 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 68/345 (19%), Positives = 130/345 (37%), Gaps = 91/345 (26%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP---------VKKKKIKREIKILTDLS 90 Y+ ++G G+++ V + + + ++ K +K V ++ I+RE+ IL ++ Sbjct: 13 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ 72 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 H N+I L ++ ++ L Sbjct: 73 ---------------------------------------HPNVITLHEVYENKTD--VIL 91 Query: 151 VFEYVDNV---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN 207 + E V DF LT+ E ++ ++L + Y HS+ I H D+KP N+M+ +N Sbjct: 92 IGELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRN 151 Query: 208 ---KKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASM 264 ++++ID+GLA E+ + F PE +V+Y D+WS G + + Sbjct: 152 VPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPE-IVNYEPLGLEADMWSIGVITYIL 210 Query: 265 IFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIN 324 + PF G + + L + V + Sbjct: 211 LSGASPFL-GDTKQETLANVSAV---------------------------------NYEF 236 Query: 325 DGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 + + + D I LL D ++R+T ++++ HPW P Q Sbjct: 237 EDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQ 281 >5YV8-A nrPDB Length = 298 Score = 213 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 65/330 (19%), Positives = 130/330 (39%), Gaps = 52/330 (15%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 Y +++++G+G Y V + +K+L KKK+ R+ P Sbjct: 13 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVL---SKKKLIRQA-------GFPRRPP 62 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 + Q ++ + I H N++ L +++ DP +VFE V+ Sbjct: 63 PRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQ 122 Query: 158 VDFRIL--YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDW 215 + L++ + RFY +L+K ++Y H I+HRD+KP N+++ ++ +++ D+ Sbjct: 123 GPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG-EDGHIKIADF 181 Query: 216 GLAEFYH-VNMEYNVRVASRFFKGPELLVDYRMY--DYSLDLWSFGTMLASMIFKREPFF 272 G++ + + + V + F PE L + R +LD+W+ G L +F + PF Sbjct: 182 GVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF- 240 Query: 273 HGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSG 332 + + I+ F + + Sbjct: 241 -------------------------------MDERIMCLHSKIKSQALEFPDQPD----I 265 Query: 333 NDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 +++ DLI +L + + R+ E HPW Sbjct: 266 AEDLKDLITRMLDKNPESRIVVPEIKLHPW 295 >3TAC-A nrPDB Length = 361 Score = 213 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 69/344 (20%), Positives = 125/344 (36%), Gaps = 95/344 (27%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVK--------KKKIKREIKILTDLSN 91 YE+ +G+G +S V + + ++ + +K++ K + +KRE I L + Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH 87 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 +I+ L + +V Sbjct: 88 ---------------------------------------PHIVELLETYSS--DGMLYMV 106 Query: 152 FEYVDNVDFRILYPK-------LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID 204 FE++D D K ++ YM ++L+AL YCH I+HRDVKPH V++ Sbjct: 107 FEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLA 166 Query: 205 HK--NKKLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTML 261 K + ++L +G+A + + RV + F PE++ Y +D+W G +L Sbjct: 167 SKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVV-KREPYGKPVDVWGCGVIL 225 Query: 262 ASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 ++ PF+ + + I K ++ Sbjct: 226 FILLSGCLPFYGTKER---------------------------------LFEGIIKGKYK 252 Query: 322 FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 H+ ++ DL+ +L D ER+T EA+ HPW Sbjct: 253 MNPRQWSHI--SESAKDLVRRMLMLDPAERITVYEALNHPWLKE 294 >3MV5-A nrPDB Length = 342 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 71/351 (20%), Positives = 130/351 (37%), Gaps = 85/351 (24%) Query: 30 VIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDL 89 +D ++E +G+G + +V + + +K+LK K+ I + ++ L Sbjct: 2 AMDPRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILK---KEVIVAKDEVAHTL 58 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 + +V + H + L Sbjct: 59 TENRVLQNS------------------------------RHPFLTALKYSF--QTHDRLC 86 Query: 150 LVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHS-MGIMHRDVKPHNVMIDH 205 V EY + + + ++ RFY E++ ALDY HS +++RD+K N+M+D Sbjct: 87 FVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD- 145 Query: 206 KNKKLRLIDWGLAEF-YHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASM 264 K+ +++ D+GL + + + PE+L D Y ++D W G ++ M Sbjct: 146 KDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND-YGRAVDWWGLGVVMYEM 204 Query: 265 IFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIN 324 + R PF++ + ++L +++ L EI PR Sbjct: 205 MCGRLPFYN--QDHEKLFELI------------LMEEIRFPRTL---------------- 234 Query: 325 DGNKHLSGNDEIIDLIDNLLRYDHQERL-----TAKEAMGHPWFAPIREQI 370 E L+ LL+ D ++RL AKE M H +FA I Q Sbjct: 235 --------GPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQH 277 >2X4F-A nrPDB Length = 373 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 68/330 (20%), Positives = 132/330 (40%), Gaps = 84/330 (25%) Query: 44 NKVGRGKYSEVFQGVKLDSKVKIVIKMLKP---VKKKKIKREIKILTDLSNEKVPPTTLP 100 +G G++ +V + + + +K+ K++K K+++K EI ++ L Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLD---------- 144 Query: 101 FQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDF 160 HAN+I L+D + LV EYVD + Sbjct: 145 -----------------------------HANLIQLYDAFES--KNDIVLVMEYVDGGEL 173 Query: 161 ----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM-IDHKNKKLRLIDW 215 LT+L+ +M ++ + + + H M I+H D+KP N++ ++ K++++ID+ Sbjct: 174 FDRIIDESYNLTELDTILFMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDF 233 Query: 216 GLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGT 275 GLA Y + V + F PE++ +Y + D+WS G + ++ PF G Sbjct: 234 GLARRYKPREKLKVNFGTPEFLAPEVV-NYDFVSFPTDMWSVGVIAYMLLSGLSPFL-GD 291 Query: 276 SNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDE 335 ++ + L I+ R+ + + ++E Sbjct: 292 NDAETLNNILAC---------------------------------RWDLEDEEFQDISEE 318 Query: 336 IIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 + I LL + R++A EA+ HPW + Sbjct: 319 AKEFISKLLIKEKSWRISASEALKHPWLSD 348 >3UDB-A nrPDB Length = 317 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 58/332 (17%), Positives = 113/332 (34%), Gaps = 75/332 (22%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVP 95 ++ YE+ +G G + + + +K Sbjct: 17 DSDRYELVKDIGAGNFGVARLMRDKQANELVAVK-------------------------- 50 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 Y + E + + ++ I + H NI+ ++I P A+V EY Sbjct: 51 -----------YIERGEKIDENVKREIINHRSLRHPNIVRFKEVILTPTH--LAIVMEYA 97 Query: 156 DNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID-HKNKKLR 211 + + ++ E RF+ +L+ + Y H+M + HRD+K N ++D +L+ Sbjct: 98 SGGELFERICNAGRFSEDEARFFFQQLISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLK 157 Query: 212 LIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 + D+G ++ ++ + V + + PE+L+ D+WS G L M+ PF Sbjct: 158 IADFGYSKASVLHSQPKSAVGTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPF 217 Query: 272 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLS 331 + K K + Y + Y+ Sbjct: 218 ED-----------------PEEPKNFRKTIHRILNVQYAIPDYVH--------------- 245 Query: 332 GNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + E LI + D +R++ E H WF Sbjct: 246 ISPECRHLISRIFVADPAKRISIPEIRNHEWF 277 >5KCV-A nrPDB Length = 460 Score = 210 bits (535), Expect = 6e-55, Method: Composition-based stats. Identities = 70/347 (20%), Positives = 128/347 (36%), Gaps = 85/347 (24%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 93 ++E +G+G + +V + + +K+LK K+ I + ++ L+ + Sbjct: 158 RVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILK---KEVIVAKDEVAHTLTENR 214 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 V + H + L V E Sbjct: 215 VLQNS------------------------------RHPFLTALKYSF--QTHDRLCFVME 242 Query: 154 YVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHS-MGIMHRDVKPHNVMIDHKNKK 209 Y + + + ++ RFY E++ ALDY HS +++RD+K N+M+D K+ Sbjct: 243 YANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLD-KDGH 301 Query: 210 LRLIDWGLAEF-YHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 268 +++ D+GL + + + PE+L D Y ++D W G ++ M+ R Sbjct: 302 IKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDND-YGRAVDWWGLGVVMYEMMCGR 360 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 PF++ + ++L +++ L EI PR Sbjct: 361 LPFYN--QDHEKLFELI------------LMEEIRFPRTL-------------------- 386 Query: 329 HLSGNDEIIDLIDNLLRYDHQERL-----TAKEAMGHPWFAPIREQI 370 E L+ LL+ D ++RL AKE M H +FA I Q Sbjct: 387 ----GPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQH 429 >2JDO-A nrPDB Length = 342 Score = 210 bits (535), Expect = 6e-55, Method: Composition-based stats. Identities = 69/349 (19%), Positives = 130/349 (37%), Gaps = 84/349 (24%) Query: 30 VIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDL 89 +D D++ +G+G + +V + + +K+L+ K+ I + ++ + Sbjct: 2 AMDPKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILR---KEVIIAKDEVAHTV 58 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 + +V T H + L Sbjct: 59 TESRVLQNT------------------------------RHPFLTALKYAF--QTHDRLC 86 Query: 150 LVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK 206 V EY + + + T+ RFY E++ AL+Y HS +++RD+K N+M+D K Sbjct: 87 FVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLD-K 145 Query: 207 NKKLRLIDWGLAEF-YHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 + +++ D+GL + + + PE+L D Y ++D W G ++ M+ Sbjct: 146 DGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDND-YGRAVDWWGLGVVMYEMM 204 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 R PF++ + ++L +++ L EI PR Sbjct: 205 CGRLPFYN--QDHERLFELI------------LMEEIRFPRTL----------------- 233 Query: 326 GNKHLSGNDEIIDLIDNLLRYDHQERL-----TAKEAMGHPWFAPIREQ 369 + E L+ LL+ D ++RL AKE M H +F I Q Sbjct: 234 -------SPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQ 275 >3COM-A nrPDB Length = 314 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 55/338 (16%), Positives = 115/338 (34%), Gaps = 84/338 (24%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPV-KKKKIKREIKILTDLSNEKV 94 + +++ K+G G Y V++ + ++ + IK + ++I +EI I+ + Sbjct: 27 PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDS--- 83 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 +++ + +V EY Sbjct: 84 ------------------------------------PHVVKYYGSYFKNTD--LWIVMEY 105 Query: 155 VDNVD----FRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 R+ LT+ EI + LK L+Y H M +HRD+K N++++ + Sbjct: 106 CGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEG-HA 164 Query: 211 RLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 +L D+G+A + + N + + F+ PE++ + Y+ D+WS G M + Sbjct: 165 KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEI-GYNCVADIWSLGITAIEMAEGKP 223 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 P+ ++ + I + K Sbjct: 224 PY----ADIHPMRAIFMIPTNP-------------------------------PPTFRKP 248 Query: 330 LSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIR 367 +D D + L ++R TA + + HP+ + Sbjct: 249 ELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAK 286 >6FDY-U nrPDB Length = 276 Score = 209 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 71/343 (20%), Positives = 123/343 (35%), Gaps = 88/343 (25%) Query: 33 WSTNTKD-YEIENKVGRGKYSEVFQGV-KLDSKVKIVIKM-----LKPVKKKKIKREIKI 85 W D + + ++G G Y+ V++ K D++ + IK L + + EI+I Sbjct: 5 WGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEI 64 Query: 86 LTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPIS 145 L + H +I+ L D D S Sbjct: 65 LKGIR---------------------------------------HPHIVQLKDFQWD--S 83 Query: 146 KTPALVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM 202 L+ E+ D L + R +M +L AL + H I H D+KP N++ Sbjct: 84 DNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNIL 143 Query: 203 IDH-KNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTML 261 + + L+L D+G A+ E +V S + PE++ + YD +DLWS G +L Sbjct: 144 LSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCQRQ-YDARVDLWSMGVIL 202 Query: 262 ASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 +F + PF R F ++++ IR Sbjct: 203 YEALFGQPPF--------------------------------ASRSFSELEEKIRS---N 227 Query: 322 FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + + + + DL+ LL D R++ ++ HPW Sbjct: 228 RVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVD 270 >1FOT-A nrPDB Length = 318 Score = 208 bits (530), Expect = 2e-54, Method: Composition-based stats. Identities = 66/340 (19%), Positives = 135/340 (39%), Gaps = 85/340 (25%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 +D++I +G G + V + +K+LK K+I +K + ++E++ + Sbjct: 6 QDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLK----KEIVVRLKQVEHTNDERLMLS 61 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 + H II ++ +D ++ ++ +Y++ Sbjct: 62 IVT-----------------------------HPFIIRMWGTFQD--AQQIFMIMDYIEG 90 Query: 158 VDFRILY---PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLID 214 + L + + +FY E+ AL+Y HS I++RD+KP N+++D KN +++ D Sbjct: 91 GELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLD-KNGHIKITD 149 Query: 215 WGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHG 274 +G A++ + + PE++ + Y+ S+D WSFG ++ M+ PF+ Sbjct: 150 FGFAKYVPD--VTYTLCGTPDYIAPEVV-STKPYNKSIDWWSFGILIYEMLAGYTPFYDS 206 Query: 275 TSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGND 334 T + +L E+ P F N+ Sbjct: 207 N--------------TMKTYEKILNAELRFPPFF------------------------NE 228 Query: 335 EIIDLIDNLLRYDHQERL-----TAKEAMGHPWFAPIREQ 369 ++ DL+ L+ D +RL ++ HPWF + + Sbjct: 229 DVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKEVVWE 268 >2HW6-A nrPDB Length = 307 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 73/346 (21%), Positives = 128/346 (36%), Gaps = 84/346 (24%) Query: 40 YEIE-NKVGRGKYSEVFQGVKLDSKVKIVIKMLKPV---KKKKIKREIKILTDLSNEKVP 95 Y++ +G G Y++V V L + + +K+++ + ++ RE++ L Sbjct: 14 YKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQ----- 68 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 G+ NI+ L + +D LVFE + Sbjct: 69 ---------------------------------GNKNILELIEFFEDDTRF--YLVFEKL 93 Query: 156 DNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK--KL 210 K + E + ++ ALD+ H+ GI HRD+KP N++ + K + Sbjct: 94 QGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPV 153 Query: 211 RLIDWGLAEFYHVN--------MEYNVRVASRFFKGPELLV----DYRMYDYSLDLWSFG 258 ++ D+ L +N E S + PE++ YD DLWS G Sbjct: 154 KICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLG 213 Query: 259 TMLASMIFKREPF--FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIR 316 +L M+ PF G ++ +V FE I+ Sbjct: 214 VVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFES-------------------IQ 254 Query: 317 KPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 + + F + H+ + E DLI LL D ++RL+A + + HPW Sbjct: 255 EGKYEFPDKDWAHI--SSEAKDLISKLLVRDAKQRLSAAQVLQHPW 298 >4JXF-A nrPDB Length = 266 Score = 208 bits (529), Expect = 4e-54, Method: Composition-based stats. Identities = 64/339 (18%), Positives = 131/339 (38%), Gaps = 92/339 (27%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML------KPVKKKKIKREIKILTDLS 90 +D+++ N +G+G ++ V++ + + +++ IKM+ K ++++ E+KI L Sbjct: 6 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLK 65 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 H +I+ L++ +D S L Sbjct: 66 ---------------------------------------HPSILELYNYFED--SNYVYL 84 Query: 151 VFEYVDNVD----FRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK 206 V E N + + ++ E R +M +++ + Y HS GI+HRD+ N+++ + Sbjct: 85 VLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLT-R 143 Query: 207 NKKLRLIDWGLAEFYH-VNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 N +++ D+GLA + ++ + + PE + + D+WS G M +++ Sbjct: 144 NMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPE-IATRSAHGLESDVWSLGCMFYTLL 202 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 R PF + + L K+V + D Sbjct: 203 IGRPPF-DTDTVKNTLNKVV-------------------------------------LAD 224 Query: 326 GNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + E DLI LLR + +RL+ + HP+ + Sbjct: 225 YEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMS 263 >4D2V-A nrPDB Length = 356 Score = 207 bits (527), Expect = 5e-54, Method: Composition-based stats. Identities = 70/333 (21%), Positives = 128/333 (38%), Gaps = 89/333 (26%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP----VKKKKIKREIKILTDLSNEKVP 95 YE+ +G G +++V + + + IK++ +IK EI+ L +L Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLR----- 85 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 H +I L+ +++ + +V EY Sbjct: 86 ----------------------------------HQHICQLYHVLE--TANKIFMVLEYC 109 Query: 156 DNV---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRL 212 D+ I +L++ E R +++ A+ Y HS G HRD+KP N++ D +K L+L Sbjct: 110 PGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHK-LKL 168 Query: 213 IDWGLAEFYHVNMEYNVR--VASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 ID+GL N +Y+++ + + PEL+ D+WS G +L ++ P Sbjct: 169 IDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLP 228 Query: 271 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 330 F + + KI++ G D K+L I Sbjct: 229 F-DDDTAAALVAKIMR--GKYDVPKWLSPSSIL--------------------------- 258 Query: 331 SGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 L+ +L+ D ++R++ K + HPW Sbjct: 259 --------LLQQMLQVDPKKRISMKNLLNHPWI 283 >5D9K-A nrPDB Length = 330 Score = 207 bits (527), Expect = 5e-54, Method: Composition-based stats. Identities = 67/343 (19%), Positives = 129/343 (37%), Gaps = 84/343 (24%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVP 95 + +E+ +G+G + +VF K+ + +K +KK +K ++ T + + + Sbjct: 28 DPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILV 87 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 H I+ L L+ +++ Sbjct: 88 EVN-------------------------------HPFIVKLHYAF--QTEGKLYLILDFL 114 Query: 156 DNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRL 212 D K T+ +++FY+ EL ALD+ HS+GI++RD+KP N+++D + ++L Sbjct: 115 RGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEG-HIKL 173 Query: 213 IDWGLAEFYHVNMEY-NVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 D+GL++ + + + + PE++ + R + S D WSFG ++ M+ PF Sbjct: 174 TDFGLSKESIDHEKKAYSFCGTVEYMAPEVV-NRRGHTQSADWWSFGVLMFEMLTGTLPF 232 Query: 272 FHGTSNTDQLVKIVKV-LGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 330 G + + I+K LG F Sbjct: 233 -QGKDRKETMTMILKAKLGMPQF------------------------------------- 254 Query: 331 SGNDEIIDLIDNLLRYDHQERLTA-----KEAMGHPWFAPIRE 368 + E L+ L + + RL A +E H +F+ I Sbjct: 255 -LSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDW 296 >6CMJ-A nrPDB Length = 321 Score = 207 bits (527), Expect = 6e-54, Method: Composition-based stats. Identities = 64/330 (19%), Positives = 128/330 (38%), Gaps = 67/330 (20%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 Y +++++G+G Y V + +K+L KKK+ R+ Sbjct: 34 DQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVL---SKKKLIRQAG------------- 77 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 Q ++ + I H N++ L +++ DP +VFE V+ Sbjct: 78 ---------GCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQ 128 Query: 158 VDFRIL--YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDW 215 + L++ + RFY +L+K ++Y H I+HRD+KP N+++ ++ +++ D+ Sbjct: 129 GPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVG-EDGHIKIADF 187 Query: 216 GLAEFYH-VNMEYNVRVASRFFKGPELLVDYRMY--DYSLDLWSFGTMLASMIFKREPFF 272 G++ + + + V + F PE L + R +LD+W+ G L +F + PF Sbjct: 188 GVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF- 246 Query: 273 HGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSG 332 + + I+ F + + Sbjct: 247 -------------------------------MDERIMCLHSKIKSQALEFPDQPD----I 271 Query: 333 NDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 +++ DLI +L + + R+ E HPW Sbjct: 272 AEDLKDLITRMLDKNPESRIVVPEIKLHPW 301 >1NY3-A nrPDB Length = 400 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 71/337 (21%), Positives = 123/337 (36%), Gaps = 81/337 (24%) Query: 37 TKDYEIE-NKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVP 95 DY++ +G G +V Q ++ K +KML+ K +RE+++ Sbjct: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ--DCPKARREVEL---------- 107 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD--PISKTPALVFE 153 + +I+ + D+ ++ K +V E Sbjct: 108 ----------------------------HWRASQCPHIVRIVDVYENLYAGRKCLLIVME 139 Query: 154 YVDNVDFRILYP-----KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK-- 206 +D + T+ E M + +A+ Y HS+ I HRDVKP N++ K Sbjct: 140 CLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRP 199 Query: 207 NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 N L+L D+G A+ + + ++ PE+L YD S D+WS G ++ ++ Sbjct: 200 NAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLC 258 Query: 267 KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG 326 PF+ M IR + F N Sbjct: 259 GYPPFYSNHG----------------------------LAISPGMKTRIRMGQYEFPNPE 290 Query: 327 NKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + ++E+ LI NLL+ + +R+T E M HPW Sbjct: 291 WSEV--SEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 325 >4L42-A nrPDB Length = 346 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 73/344 (21%), Positives = 132/344 (38%), Gaps = 80/344 (23%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKV 94 + +E+ +G+G Y +VFQ K+ I +K +KK I R K Sbjct: 15 IRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK---------- 64 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 D +T + ++L+ ++ H I+ L L+ EY Sbjct: 65 ---------DTAHTKAERNILEEVK----------HPFIVDLIYAF--QTGGKLYLILEY 103 Query: 155 VDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 + + + + + FY+ E+ AL + H GI++RD+KP N+M++H+ ++ Sbjct: 104 LSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQG-HVK 162 Query: 212 LIDWGLAEF-YHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 L D+GL + H + + + PE+L+ ++ ++D WS G ++ M+ P Sbjct: 163 LTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM-RSGHNRAVDWWSLGALMYDMLTGAPP 221 Query: 271 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 330 F G + + KI+K ++ LP Sbjct: 222 F-TGENRKKTIDKILKC-------------KLNLPPYL---------------------- 245 Query: 331 SGNDEIIDLIDNLLRYDHQERL-----TAKEAMGHPWFAPIREQ 369 E DL+ LL+ + RL A E HP+F I + Sbjct: 246 --TQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWE 287 >3DAK-A nrPDB Length = 290 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 61/360 (16%), Positives = 119/360 (33%), Gaps = 91/360 (25%) Query: 29 TVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKK----KIKREIK 84 + + WS N DYE++ +G G + V K K+ IK + K + ++ +EI+ Sbjct: 1 SALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQ 60 Query: 85 ILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI 144 ++ H NI+ + + Sbjct: 61 AMSQCH---------------------------------------HPNIVSYYTSF--VV 79 Query: 145 SKTPALVFEYVDNVDFRILYPK-----------LTDLEIRFYMFELLKALDYCHSMGIMH 193 LV + + + L + I + E+L+ L+Y H G +H Sbjct: 80 KDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIH 139 Query: 194 RDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYN------VRVASRFFKGPELLVDYRM 247 RDVK N+++ ++ +++ D+G++ F + V + + PE++ R Sbjct: 140 RDVKAGNILLG-EDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRG 198 Query: 248 YDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPRE 307 YD+ D+WSFG + P+ ++ + Sbjct: 199 YDFKADIWSFGITAIELATGAAPY----------------------------HKYPPMKV 230 Query: 308 FYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIR 367 Q + D +I L+ D ++R TA E + H +F + Sbjct: 231 LMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAK 290 >3FXW-A nrPDB Length = 336 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 70/339 (20%), Positives = 125/339 (36%), Gaps = 82/339 (24%) Query: 37 TKDYEIEN-KVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVP 95 T DY++ +G G +V + + K +K+L K ++E+ Sbjct: 27 TDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL--YDSPKARQEVD----------- 73 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP--ISKTPALVFE 153 +G +I+ + D+ ++ + ++ E Sbjct: 74 ---------------------------HHWQASGGPHIVCILDVYENMHHGKRCLLIIME 106 Query: 154 YVDNVDFRILYPK-----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID--HK 206 ++ + + T+ E M ++ A+ + HS I HRDVKP N++ K Sbjct: 107 CMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEK 166 Query: 207 NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 + L+L D+G A+ N + ++ PE+L YD S D+WS G ++ ++ Sbjct: 167 DAVLKLTDFGFAKETTQNA-LQTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLC 224 Query: 267 KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG 326 PF+ SNT Q + M + IR + F N Sbjct: 225 GFPPFY---SNTGQAI-------------------------SPGMKRRIRLGQYGFPNPE 256 Query: 327 NKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 + +++ LI LL+ D ERLT + M HPW Sbjct: 257 WSEV--SEDAKQLIRLLLKTDPTERLTITQFMNHPWINQ 293 >3HKO-A nrPDB Length = 345 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 76/359 (21%), Positives = 142/359 (39%), Gaps = 65/359 (18%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK--------PVKKKKIKREIKILTDL 89 K Y ++ +G+G Y V ++ ++ IK++ P ++IK E++++ L Sbjct: 26 KKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKL 85 Query: 90 SNEKVPPTTLPFQKDQYYTNQKE-----DVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI 144 + + ++ +QY E +L + +I D D++K I Sbjct: 86 HHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKC------AMDVVKTQI 139 Query: 145 SKTPALVFEYVDNVDFRILYPKL----TDLEIRFYMFELLKALDYCHSMGIMHRDVKPHN 200 P E N L + I M ++ AL Y H+ GI HRD+KP N Sbjct: 140 CPCPEC-NEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPEN 198 Query: 201 VMI-DHKNKKLRLIDWGLAEFYH--VNMEY---NVRVASRFFKGPELLV-DYRMYDYSLD 253 + +K+ +++L+D+GL++ ++ N EY + + +F PE+L Y D Sbjct: 199 FLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCD 258 Query: 254 LWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQ 313 WS G +L ++ PF G ++ D + +++ Sbjct: 259 AWSAGVLLHLLLMGAVPF-PGVNDADTISQVLN--------------------------- 290 Query: 314 YIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK 372 + + + + DL+ NLL + ER A A+ HPW + ++I K Sbjct: 291 ------KKLCFENPNYNVLSPLARDLLSNLLNRNVDERFDAMRALQHPWISQFSDKIYK 343 >5D7A-A nrPDB Length = 308 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 61/346 (17%), Positives = 120/346 (34%), Gaps = 91/346 (26%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPV--KKKKIKREIKILTDLSNEKVPPT 97 +E+ VG G Y +V++G + + IK++ ++++IK+EI +L S+ Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSH------ 72 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP----ISKTPALVFE 153 H NI + + LV E Sbjct: 73 --------------------------------HRNIATYYGAFIKKNPPGMDDQLWLVME 100 Query: 154 YVDNVDFRILYP-----KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK 208 + L L + I + E+L+ L + H ++HRD+K NV++ +N Sbjct: 101 FCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLT-ENA 159 Query: 209 KLRLIDWGL-AEFYHVNMEYNVRVASRFFKGPELLVDYR----MYDYSLDLWSFGTMLAS 263 +++L+D+G+ A+ N + + ++ PE++ YD+ DLWS G Sbjct: 160 EVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIE 219 Query: 264 MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFI 323 M P + + ++ +PR Sbjct: 220 MAEGAPPL---------------------CDMHPMRALFLIPRN---------------P 243 Query: 324 NDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 K + + I++ L +H +R ++ M HP+ + Sbjct: 244 APRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNE 289 >2OZA-A nrPDB Length = 356 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 71/337 (21%), Positives = 123/337 (36%), Gaps = 81/337 (24%) Query: 37 TKDYEIE-NKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVP 95 DY++ +G G +V Q ++ K +KML+ K +RE+++ Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ--DCPKARREVEL---------- 63 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD--PISKTPALVFE 153 + +I+ + D+ ++ K +V E Sbjct: 64 ----------------------------HWRASQCPHIVRIVDVYENLYAGRKCLLIVME 95 Query: 154 YVDNVDFRILYP-----KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK-- 206 +D + T+ E M + +A+ Y HS+ I HRDVKP N++ K Sbjct: 96 CLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRP 155 Query: 207 NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 N L+L D+G A+ + + ++ PE+L YD S D+WS G ++ ++ Sbjct: 156 NAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLC 214 Query: 267 KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG 326 PF+ M IR + F N Sbjct: 215 GYPPFYSNHG----------------------------LAISPGMKTRIRMGQYEFPNPE 246 Query: 327 NKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + ++E+ LI NLL+ + +R+T E M HPW Sbjct: 247 WSEV--SEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 281 >4RLP-A nrPDB Length = 288 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 73/344 (21%), Positives = 132/344 (38%), Gaps = 80/344 (23%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKV 94 + +E+ +G+G Y +VFQ K+ I +K +KK I R K Sbjct: 2 IRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAK---------- 51 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 D +T + ++L+ ++ H I+ L L+ EY Sbjct: 52 ---------DTAHTKAERNILEEVK----------HPFIVDLIYAF--QTGGKLYLILEY 90 Query: 155 VDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 + + + + + FY+ E+ AL + H GI++RD+KP N+M++H+ ++ Sbjct: 91 LSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQG-HVK 149 Query: 212 LIDWGLAEF-YHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 L D+GL + H + + + PE+L+ ++ ++D WS G ++ M+ P Sbjct: 150 LTDFGLCKESIHDGTVTHTFCGTIEYMAPEILM-RSGHNRAVDWWSLGALMYDMLTGAPP 208 Query: 271 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 330 F G + + KI+K ++ LP Sbjct: 209 F-TGENRKKTIDKILKC-------------KLNLPPYL---------------------- 232 Query: 331 SGNDEIIDLIDNLLRYDHQERL-----TAKEAMGHPWFAPIREQ 369 E DL+ LL+ + RL A E HP+F I + Sbjct: 233 --TQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWE 274 >6FD3-A nrPDB Length = 300 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 62/350 (17%), Positives = 127/350 (36%), Gaps = 84/350 (24%) Query: 21 EEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK---PVKKK 77 EE + +++ K Y K+G+G V+ + + + ++ IK + KK+ Sbjct: 5 EEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE 64 Query: 78 KIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLF 137 I EI ++ + N NI++ Sbjct: 65 LIINEILVMRENKN---------------------------------------PNIVNYL 85 Query: 138 DIIKDPISKTPALVFEYVDNVDFRILYPK--LTDLEIRFYMFELLKALDYCHSMGIMHRD 195 D + +V EY+ + + + + +I E L+ALD+ HS ++HRD Sbjct: 86 DSYL--VGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRD 143 Query: 196 VKPHNVMIDHKNKKLRLIDWGL-AEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDL 254 +K N+++ + ++L D+G A+ + + V + ++ PE++ + Y +D+ Sbjct: 144 IKSDNILLG-MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRKAYGPKVDI 201 Query: 255 WSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQY 314 WS G M M+ P+ + N + + ++ GT + + Sbjct: 202 WSLGIMAIEMVEGEPPYLN--ENPLRALYLIATNGTPELQN------------------- 240 Query: 315 IRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + D ++ L D R +AKE + HP+ Sbjct: 241 --------------PERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLK 276 >3KA0-A nrPDB Length = 320 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 71/337 (21%), Positives = 123/337 (36%), Gaps = 81/337 (24%) Query: 37 TKDYEIE-NKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVP 95 DY++ +G G +V Q ++ K +KML+ K +RE+++ Sbjct: 14 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ--DCPKARREVEL---------- 61 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD--PISKTPALVFE 153 + +I+ + D+ ++ K +V E Sbjct: 62 ----------------------------HWRASQCPHIVRIVDVYENLYAGRKCLLIVME 93 Query: 154 YVDNVDFRILYP-----KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK-- 206 +D + T+ E M + +A+ Y HS+ I HRDVKP N++ K Sbjct: 94 CLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRP 153 Query: 207 NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 N L+L D+G A+ + + ++ PE+L YD S D+WS G ++ ++ Sbjct: 154 NAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVL-GPEKYDKSCDMWSLGVIMYILLC 212 Query: 267 KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG 326 PF+ M IR + F N Sbjct: 213 GYPPFYSNHG----------------------------LAISPGMKTRIRMGQYEFPNPE 244 Query: 327 NKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + ++E+ LI NLL+ + +R+T E M HPW Sbjct: 245 WSEV--SEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 279 >4FIE-A nrPDB Length = 423 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 59/350 (16%), Positives = 124/350 (35%), Gaps = 84/350 (24%) Query: 21 EEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK-- 78 E++ V+D + K+G G V S + +K + K+++ Sbjct: 134 EQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRE 193 Query: 79 -IKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLF 137 + E+ I+ D H N++ ++ Sbjct: 194 LLFNEVVIMRDYQ---------------------------------------HENVVEMY 214 Query: 138 DIIKDPISKTPALVFEYVDNVDF--RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRD 195 + + +V E+++ + + ++ + +I +L+AL H+ G++HRD Sbjct: 215 NSYL--VGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 272 Query: 196 VKPHNVMIDHKNKKLRLIDWGL-AEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDL 254 +K ++++ H + +++L D+G A+ V + ++ PEL+ Y +D+ Sbjct: 273 IKSDSILLTH-DGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPEVDI 330 Query: 255 WSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQY 314 WS G M+ M+ P+F+ K + LP ++ Sbjct: 331 WSLGIMVIEMVDGEPPYFN-----------------EPPLKAMKMIRDNLPPRLKNLH-- 371 Query: 315 IRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + + +D LL D +R TA E + HP+ A Sbjct: 372 ----------------KVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLA 405 >4CQG-A nrPDB Length = 331 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 70/332 (21%), Positives = 125/332 (37%), Gaps = 89/332 (26%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP----VKKKKIKREIKILTDLSNEKVP 95 YE+ +G G +++V + + + IK++ ++K EI L L Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLR----- 65 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 H +I L+ +++ +V EY Sbjct: 66 ----------------------------------HQHICQLYHVLE--TKNKIFMVLEYC 89 Query: 156 DNV---DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRL 212 D+ I +L++ E R ++L A+ Y HS G HRD+KP N++ D +N KL+L Sbjct: 90 PGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQGYAHRDLKPENLLFD-ENHKLKL 148 Query: 213 IDWGLAEFYHVNMEYNVR--VASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 ID+GL N +Y+++ S + PEL+ D+WS G +L ++ P Sbjct: 149 IDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLP 208 Query: 271 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 330 F + KI++ G + K+L I Sbjct: 209 F-DDDNVMALYKKIMR--GKYEVPKWLSPSSIL--------------------------- 238 Query: 331 SGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 L+ +L+ D ++R++ + + HPW Sbjct: 239 --------LLQQMLQVDPKKRISMRNLLNHPW 262 >3UTO-A nrPDB Length = 573 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 65/336 (19%), Positives = 124/336 (36%), Gaps = 84/336 (25%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIK-MLKP--VKKKKIKREIKILTDLSNEKV 94 Y+I ++G G + V + + + K ++ P K+ +++EI+ ++ L Sbjct: 157 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLR---- 212 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 H +++L D +D +++E+ Sbjct: 213 -----------------------------------HPTLVNLHDAFED--DNEMVMIYEF 235 Query: 155 VDNVDF----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK-NKK 209 + + + K+++ E YM ++ K L + H +H D+KP N+M K + + Sbjct: 236 MSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNE 295 Query: 210 LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 L+LID+GL V + F PE+ + + Y D+WS G + ++ Sbjct: 296 LKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEV-AEGKPVGYYTDMWSVGVLSYILLSGLS 354 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 PF G N D+ ++ VK + D + Sbjct: 355 PF--GGENDDETLRNVKSC--------------------------------DWNMDDSAF 380 Query: 330 LSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 +++ D I LL D R+T +A+ HPW P Sbjct: 381 SGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTP 416 >5X8I-B nrPDB Length = 346 Score = 203 bits (517), Expect = 7e-53, Method: Composition-based stats. Identities = 65/363 (17%), Positives = 139/363 (38%), Gaps = 71/363 (19%) Query: 40 YEIENKVGRGKYSEVFQGVKLD-SKVKIVIKMLKPVKK--KKIKREIKILTDLSNEKVPP 96 YEI + +G G + +V + + + +K++K V + + + EI++L L+ Sbjct: 15 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 74 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 T Q +++ H+GH I VFE + Sbjct: 75 TFRCVQMLEWFE------------------HHGHICI-----------------VFELLG 99 Query: 157 NVDFRILYPK----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK------ 206 + + IR +++ K++++ HS + H D+KP N++ Sbjct: 100 LSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAY 159 Query: 207 ------------NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDL 254 N ++++D+G A + + ++ V++R ++ PE+++ + D+ Sbjct: 160 NPKIKRDERTLINPDIKVVDFGSATY--DDEHHSTLVSTRHYRAPEVILAL-GWSQPCDV 216 Query: 255 WSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL-------PRE 307 WS G +L F + + L + ++LG + E Sbjct: 217 WSIGCILIEYYLGFTVF-PTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDE 275 Query: 308 FYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIR 367 +Y+ + ++ + DLI +L YD +R+T +EA+ HP+F ++ Sbjct: 276 HSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLK 335 Query: 368 EQI 370 + I Sbjct: 336 KSI 338 >4LG4-A nrPDB Length = 299 Score = 203 bits (517), Expect = 7e-53, Method: Composition-based stats. Identities = 55/338 (16%), Positives = 115/338 (34%), Gaps = 84/338 (24%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPV-KKKKIKREIKILTDLSNEKV 94 + +++ K+G G Y VF+ + +S + IK + ++I +EI I+ + Sbjct: 9 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDS--- 65 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 ++ + +V EY Sbjct: 66 ------------------------------------PYVVKYYGSYFKNTD--LWIVMEY 87 Query: 155 VDNVD----FRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 R+ L + EI + LK L+Y H M +HR++K N++++ + Sbjct: 88 CGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRNIKAGNILLNTEG-HA 146 Query: 211 RLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 +L D+G+A + + N + + F+ PE++ + Y+ D+WS G M + Sbjct: 147 KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEI-GYNCVADIWSLGITSIEMAEGKP 205 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 P+ ++ + I + K Sbjct: 206 PY----ADIHPMRAIFMIPTNP-------------------------------PPTFRKP 230 Query: 330 LSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIR 367 +D+ D + L + ++R TA + + HP+ + Sbjct: 231 ELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAK 268 >4JDH-A nrPDB Length = 346 Score = 203 bits (517), Expect = 9e-53, Method: Composition-based stats. Identities = 59/350 (16%), Positives = 124/350 (35%), Gaps = 84/350 (24%) Query: 21 EEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK-- 78 E++ V+D + K+G G V S + +K + K+++ Sbjct: 57 EQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRE 116 Query: 79 -IKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLF 137 + E+ I+ D H N++ ++ Sbjct: 117 LLFNEVVIMRDYQ---------------------------------------HENVVEMY 137 Query: 138 DIIKDPISKTPALVFEYVDNVDF--RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRD 195 + + +V E+++ + + ++ + +I +L+AL H+ G++HRD Sbjct: 138 NSYL--VGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 195 Query: 196 VKPHNVMIDHKNKKLRLIDWGL-AEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDL 254 +K ++++ H + +++L D+G A+ V + ++ PEL+ Y +D+ Sbjct: 196 IKSDSILLTH-DGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPEVDI 253 Query: 255 WSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQY 314 WS G M+ M+ P+F+ K + LP ++ Sbjct: 254 WSLGIMVIEMVDGEPPYFN-----------------EPPLKAMKMIRDNLPPRLKNLH-- 294 Query: 315 IRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + + +D LL D +R TA E + HP+ A Sbjct: 295 ----------------KVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLA 328 >4YNZ-A nrPDB Length = 342 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 72/335 (21%), Positives = 128/335 (38%), Gaps = 78/335 (23%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 Y +E +G+G+ V G+ + K+ IK++ K Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKL----------------------- 48 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNV- 158 E VL + I H +++ L D+ ++ K LV E+V Sbjct: 49 -----------SESVLMKVEREIAILKLIEHPHVLKLHDVYEN--KKYLYLVLEHVSGGE 95 Query: 159 --DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWG 216 D+ + +LT E R + +++ ALD+CHS I HRD+KP N+++D +N +R+ D+G Sbjct: 96 LFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDERN-NIRIADFG 154 Query: 217 LAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTS 276 +A + S + PE++ + D+WS G +L +++ PF Sbjct: 155 MASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVILFALLVGALPF--DDD 212 Query: 277 NTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEI 336 N QL++ VK R + M +I + Sbjct: 213 NLRQLLEKVK-------------------RGVFHMPHFIP-----------------PDC 236 Query: 337 IDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIE 371 L+ ++ D RLT + H W+ + + E Sbjct: 237 QSLLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPE 271 >2Q0N-A nrPDB Length = 301 Score = 203 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 59/350 (16%), Positives = 124/350 (35%), Gaps = 84/350 (24%) Query: 21 EEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK-- 78 E++ V+D + K+G G V S + +K + K+++ Sbjct: 12 EQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRE 71 Query: 79 -IKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLF 137 + E+ I+ D H N++ ++ Sbjct: 72 LLFNEVVIMRDYQ---------------------------------------HENVVEMY 92 Query: 138 DIIKDPISKTPALVFEYVDNVDF--RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRD 195 + + +V E+++ + + ++ + +I +L+AL H+ G++HRD Sbjct: 93 NSYL--VGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 150 Query: 196 VKPHNVMIDHKNKKLRLIDWGL-AEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDL 254 +K ++++ H + +++L D+G A+ V + ++ PEL+ Y +D+ Sbjct: 151 IKSDSILLTH-DGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPEVDI 208 Query: 255 WSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQY 314 WS G M+ M+ P+F+ K + LP ++ Sbjct: 209 WSLGIMVIEMVDGEPPYFN-----------------EPPLKAMKMIRDNLPPRLKNLH-- 249 Query: 315 IRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + + +D LL D +R TA E + HP+ A Sbjct: 250 ----------------KVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLA 283 >4XBR-A nrPDB Length = 366 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 59/350 (16%), Positives = 124/350 (35%), Gaps = 84/350 (24%) Query: 21 EEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK-- 78 E++ V+D + K+G G V S + +K + K+++ Sbjct: 77 EQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRE 136 Query: 79 -IKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLF 137 + E+ I+ D H N++ ++ Sbjct: 137 LLFNEVVIMRDYQ---------------------------------------HENVVEMY 157 Query: 138 DIIKDPISKTPALVFEYVDNVDF--RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRD 195 + + +V E+++ + + ++ + +I +L+AL H+ G++HRD Sbjct: 158 NSYL--VGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRD 215 Query: 196 VKPHNVMIDHKNKKLRLIDWGL-AEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDL 254 +K ++++ H + +++L D+G A+ V + ++ PEL+ Y +D+ Sbjct: 216 IKSDSILLTH-DGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELI-SRLPYGPEVDI 273 Query: 255 WSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQY 314 WS G M+ M+ P+F+ K + LP ++ Sbjct: 274 WSLGIMVIEMVDGEPPYFN-----------------EPPLKAMKMIRDNLPPRLKNLH-- 314 Query: 315 IRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + + +D LL D +R TA E + HP+ A Sbjct: 315 ----------------KVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLA 348 >6FYV-A nrPDB Length = 337 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 62/360 (17%), Positives = 145/360 (40%), Gaps = 63/360 (17%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLD-SKVKIVIKMLKPVKK--KKIKREIKILTDLSNEK 93 YEI + +G G + +V + + + + +K++K V + + + EI++L L++ Sbjct: 13 RARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTD 72 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 Q +++ H+GH I+ F+++ ++ Sbjct: 73 PNSVFRCVQMLEWF------------------DHHGHVCIV--FELLGLST-------YD 105 Query: 154 YVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI---------- 203 ++ F IR +++ +++++ H + H D+KP N++ Sbjct: 106 FIKENSFL----PFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYN 161 Query: 204 --------DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLW 255 KN ++++D+G A + + ++ V++R ++ PE+++ + D+W Sbjct: 162 SKMKRDERTLKNTDIKVVDFGSATY--DDEHHSTLVSTRHYRAPEVILAL-GWSQPCDVW 218 Query: 256 SFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL-------PREF 308 S G +L F + + L + ++LG + E Sbjct: 219 SIGCILIEYYLGFTVF-QTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEH 277 Query: 309 YDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 368 +Y+R+ H ++++ DL+ +L YD +R+T EA+ HP+F +++ Sbjct: 278 SSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKK 337 >1KOA-A nrPDB Length = 491 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 65/336 (19%), Positives = 124/336 (36%), Gaps = 84/336 (25%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIK-MLKP--VKKKKIKREIKILTDLSNEKV 94 Y+I ++G G + V + + + K ++ P K+ +++EI+ ++ L Sbjct: 51 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLR---- 106 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 H +++L D +D +++E+ Sbjct: 107 -----------------------------------HPTLVNLHDAFED--DNEMVMIYEF 129 Query: 155 VDNVDF----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK-NKK 209 + + + K+++ E YM ++ K L + H +H D+KP N+M K + + Sbjct: 130 MSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNE 189 Query: 210 LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 L+LID+GL V + F PE+ + + Y D+WS G + ++ Sbjct: 190 LKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEV-AEGKPVGYYTDMWSVGVLSYILLSGLS 248 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 PF G N D+ ++ VK + D + Sbjct: 249 PF--GGENDDETLRNVKSC--------------------------------DWNMDDSAF 274 Query: 330 LSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 +++ D I LL D R+T +A+ HPW P Sbjct: 275 SGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTP 310 >6AO5-A nrPDB Length = 362 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 55/338 (16%), Positives = 115/338 (34%), Gaps = 84/338 (24%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPV-KKKKIKREIKILTDLSNEKV 94 + +++ K+G G Y VF+ + +S + IK + ++I +EI I+ + Sbjct: 8 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDS--- 64 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 ++ + +V EY Sbjct: 65 ------------------------------------PYVVKYYGSYFKNTD--LWIVMEY 86 Query: 155 VDNVD----FRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 R+ L + EI + LK L+Y H M +HR++K N++++ + Sbjct: 87 CGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRNIKAGNILLNTEG-HA 145 Query: 211 RLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 +L D+G+A + + N + + F+ PE++ + Y+ D+WS G M + Sbjct: 146 KLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEI-GYNCVADIWSLGITSIEMAEGKP 204 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 P+ ++ + I + K Sbjct: 205 PY----ADIHPMRAIFMIPTNP-------------------------------PPTFRKP 229 Query: 330 LSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIR 367 +D+ D + L + ++R TA + + HP+ + Sbjct: 230 ELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAK 267 >6CKI-A nrPDB Length = 316 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 70/344 (20%), Positives = 132/344 (38%), Gaps = 80/344 (23%) Query: 40 YEIEN-KVGRGKYSEVFQGVKLDSKVKIVIKMLKPVK---KKKIKREIKILTDLSNEKVP 95 Y+++ +G G ++ V + L + + +K+++ + ++ RE+++L Sbjct: 14 YQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQ----- 68 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 GH N++ I LVFE + Sbjct: 69 ---------------------------------GHRNVLE--LIEFFEEEDRFYLVFEKM 93 Query: 156 DNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN--KKL 210 K +LE + ++ ALD+ H+ GI HRD+KP N++ +H N + Sbjct: 94 RGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPV 153 Query: 211 RLIDWGLAEFYHVNMEYN--------VRVASRFFKGPELL----VDYRMYDYSLDLWSFG 258 ++ D+GL +N + + S + PE++ + +YD DLWS G Sbjct: 154 KICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLG 213 Query: 259 TMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKP 318 +L ++ PF +G + + E P + + I++ Sbjct: 214 VILYILLSGYPPF----------------VGRCGSDCGWDRGE-ACPACQNMLFESIQEG 256 Query: 319 WHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 + F + H+S DLI LL D ++RL+A + + HPW Sbjct: 257 KYEFPDKDWAHISCA--AKDLISKLLVRDAKQRLSAAQVLQHPW 298 >5X3F-B nrPDB Length = 393 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 66/381 (17%), Positives = 140/381 (36%), Gaps = 94/381 (24%) Query: 2 KCRVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKD------YEIENKVGRGKYSEVF 55 + +EA+ ++ + D+ W T +++ ++ +G G + V Sbjct: 45 SANLLAEAKKLNDVQAFLAKAKEDFLK---KWETPSQNTAQLDQFDRIKTLGTGSFGRVM 101 Query: 56 QGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVL 115 +S +K+L K K+K +I L+ +++ Sbjct: 102 LVKHKESGNHYAMKILDKQKVVKLK---QIEHTLNEKRILQAVNF--------------- 143 Query: 116 KFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILY---PKLTDLEI 172 ++ L KD + +V EYV + + ++ Sbjct: 144 ---------------PFLVKLEFSFKDNSN--LYMVMEYVAGGEMFSHLRRIGRFSEPHA 186 Query: 173 RFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVA 232 RFY +++ +Y HS+ +++RD+KP N++ID + +++ D+G A+ V Sbjct: 187 RFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-IQVTDFGFAK--RVKGRTWTLCG 243 Query: 233 SRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSD 292 + + PE+++ + Y+ ++D W+ G ++ M PFF DQ ++I + + Sbjct: 244 TPEYLAPEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF-----ADQPIQIYEKI---- 293 Query: 293 FEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERL 352 + ++ P F + ++ DL+ NLL+ D +R Sbjct: 294 -----VSGKVRFPSHF------------------------SSDLKDLLRNLLQVDLTKRF 324 Query: 353 -----TAKEAMGHPWFAPIRE 368 + H WFA Sbjct: 325 GNLKNGVNDIKNHKWFATTDW 345 >2F57-A nrPDB Length = 317 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 55/350 (15%), Positives = 128/350 (36%), Gaps = 84/350 (24%) Query: 21 EEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK-- 78 E++ V+ + K+G G V + + ++ +K + K+++ Sbjct: 28 EQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRE 87 Query: 79 -IKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLF 137 + E+ I+ D H N++ ++ Sbjct: 88 LLFNEVVIMRDYH---------------------------------------HDNVVDMY 108 Query: 138 DIIKDPISKTPALVFEYVDNVDF--RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRD 195 + +V E+++ + + ++ + +I +L+AL Y H+ G++HRD Sbjct: 109 SSYL--VGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRD 166 Query: 196 VKPHNVMIDHKNKKLRLIDWGL-AEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDL 254 +K ++++ + +++L D+G A+ + V + ++ PE++ Y +D+ Sbjct: 167 IKSDSILLTS-DGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVI-SRLPYGTEVDI 224 Query: 255 WSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQY 314 WS G M+ MI P+F+ + + + +LP D+ Sbjct: 225 WSLGIMVIEMIDGEPPYFN-----------------EPPLQAMRRIRDSLPPRVKDLH-- 265 Query: 315 IRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + + +D +L + +R TA+E +GHP+ Sbjct: 266 ----------------KVSSVLRGFLDLMLVREPSQRATAQELLGHPFLK 299 >6E9W-A nrPDB Length = 443 Score = 201 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 70/282 (24%), Positives = 110/282 (39%), Gaps = 44/282 (15%) Query: 21 EEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIK 80 Y D N + D +DYE+ +GRG + EV ++ +K+L K + IK Sbjct: 85 SRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLS--KFEMIK 142 Query: 81 REIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII 140 R D + ++ D++ F ++ LF Sbjct: 143 R---------------------SDSAFFWEERDIMAFANS----------PWVVQLFYAF 171 Query: 141 KDPISKTPALVFEYVDNVDFRILYPKL--TDLEIRFYMFELLKALDYCHSMGIMHRDVKP 198 +D + +V EY+ D L + RFY E++ ALD HSMG +HRDVKP Sbjct: 172 QD--DRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKP 229 Query: 199 HNVMIDHKNKKLRLIDWGLAEFYHVNM--EYNVRVASRFFKGPELLV---DYRMYDYSLD 253 N+++D K+ L+L D+G + + V + + PE+L Y D Sbjct: 230 DNMLLD-KSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECD 288 Query: 254 LWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEK 295 WS G L M+ PF+ S KI+ + F Sbjct: 289 WWSVGVFLYEMLVGDTPFY-ADSLVGTYSKIMNHKNSLTFPD 329 >5F9E-A nrPDB Length = 353 Score = 201 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 67/348 (19%), Positives = 124/348 (35%), Gaps = 79/348 (22%) Query: 27 ENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKIL 86 E + +D+E+ +G+G + +VF + IK LK Sbjct: 8 ERPSLQIKLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKD------------ 55 Query: 87 TDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISK 146 +DV + H + H+F + Sbjct: 56 --------------------VVLMDDDVECTMVEKRVLSLAWEHPFLTHMFCTF--QTKE 93 Query: 147 TPALVFEYVDNVDFRILYP---KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI 203 V EY++ D K FY E++ L + HS GI++RD+K N+++ Sbjct: 94 NLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLKLDNILL 153 Query: 204 DHKNKKLRLIDWGLAEF-YHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLA 262 D K+ +++ D+G+ + + + N + + PE+L+ + Y++S+D WSFG +L Sbjct: 154 D-KDGHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEILLGQK-YNHSVDWWSFGVLLY 211 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 M+ + PF HG + I + + ++L K Sbjct: 212 EMLIGQSPF-HGQDEEELFHSI--RMDNPFYPRWLEK----------------------- 245 Query: 323 INDGNKHLSGNDEIIDLIDNLLRYDHQERLTAK-EAMGHPWFAPIREQ 369 E DL+ L + ++RL + + HP F I + Sbjct: 246 ------------EAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWE 281 >3KN6-A nrPDB Length = 325 Score = 200 bits (509), Expect = 6e-52, Method: Composition-based stats. Identities = 67/322 (20%), Positives = 119/322 (36%), Gaps = 86/322 (26%) Query: 43 ENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQ 102 + +G G +S + V S +K++ + ++EI L Sbjct: 16 DKPLGEGSFSICRKCVHKKSNQAFAVKIISKRMEANTQKEITALKLCE------------ 63 Query: 103 KDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRI 162 GH NI+ L ++ D + LV E ++ + Sbjct: 64 --------------------------GHPNIVKLHEVFHDQLHT--FLVMELLNGGELFE 95 Query: 163 LYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK--LRLIDWGL 217 K ++ E + M +L+ A+ + H +G++HRD+KP N++ +N +++ID+G Sbjct: 96 RIKKKKHFSETEASYIMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGF 155 Query: 218 AEFYHVNME-YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF----- 271 A + + + + PELL + YD S DLWS G +L +M+ + PF Sbjct: 156 ARLKPPDNQPLKTPCFTLHYAAPELL-NQNGYDESCDLWSLGVILYTMLSGQVPFQSHDR 214 Query: 272 -FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 330 TS + + KI K + + E + Sbjct: 215 SLTCTSAVEIMKKIKKGDFSFEGEAWK--------------------------------- 241 Query: 331 SGNDEIIDLIDNLLRYDHQERL 352 + + E DLI LL D +RL Sbjct: 242 NVSQEAKDLIQGLLTVDPNKRL 263 >2UV2-A nrPDB Length = 325 Score = 200 bits (508), Expect = 8e-52, Method: Composition-based stats. Identities = 69/370 (18%), Positives = 125/370 (33%), Gaps = 95/370 (25%) Query: 20 TEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKI 79 + YE+ D + +EI ++G G + +V++ ++ V K++ ++++ Sbjct: 20 FQSMKQYEHVTRDLN-PEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEEL 78 Query: 80 ---KREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHL 136 EI IL H NI+ L Sbjct: 79 EDYMVEIDILASCD---------------------------------------HPNIVKL 99 Query: 137 FDIIKDPISKTPALVFEYVDNVD----FRILYPKLTDLEIRFYMFELLKALDYCHSMGIM 192 D ++ E+ L LT+ +I+ + L AL+Y H I+ Sbjct: 100 LDAFY--YENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYLHDNKII 157 Query: 193 HRDVKPHNVMIDHKNKKLRLIDWGL-AEFYHVNMEYNVRVASRFFKGPELLV----DYRM 247 HRD+K N++ + ++L D+G+ A+ + + + ++ PE+++ R Sbjct: 158 HRDLKAGNILFTL-DGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCETSKDRP 216 Query: 248 YDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPRE 307 YDY D+WS G L M EP H + L+KI K Sbjct: 217 YDYKADVWSLGITLIEMAE-IEPPHHELNPMRVLLKIAK--------------------- 254 Query: 308 FYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA--- 364 + + D + L + R T + + HP+ Sbjct: 255 -------------SEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDS 301 Query: 365 --PIREQIEK 372 PIRE I + Sbjct: 302 NKPIRELIAE 311 >3TXO-A nrPDB Length = 353 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 59/362 (16%), Positives = 126/362 (34%), Gaps = 84/362 (23%) Query: 17 KQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK 76 + + + + ++E +G+G + +V ++ +K+LK K Sbjct: 2 PKESSKEGNGIGVNSSNRLGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLK---K 58 Query: 77 KKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHL 136 I ++ + ++ +++ H + L Sbjct: 59 DVILQDDDVECTMTEKRILSLARN-----------------------------HPFLTQL 89 Query: 137 FDIIKDPISKTPALVFEYVDNVDFRILYP---KLTDLEIRFYMFELLKALDYCHSMGIMH 193 F + P V E+V+ D + + RFY E++ AL + H GI++ Sbjct: 90 FCCFQTP--DRLFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIY 147 Query: 194 RDVKPHNVMIDHKNKKLRLIDWGLAEF-YHVNMEYNVRVASRFFKGPELLVDYRMYDYSL 252 RD+K NV++DH+ +L D+G+ + + + + PE+L + +Y ++ Sbjct: 148 RDLKLDNVLLDHEG-HCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEM-LYGPAV 205 Query: 253 DLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMD 312 D W+ G +L M+ PF N D L + + L E+ P + Sbjct: 206 DWWAMGVLLYEMLCGHAPF--EAENEDDLFEAI------------LNDEVVYPTWLH--- 248 Query: 313 QYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERL-TAKE-----AMGHPWFAPI 366 ++ ++ + + + RL + + + HP+F I Sbjct: 249 ---------------------EDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEI 287 Query: 367 RE 368 Sbjct: 288 DW 289 >4CSV-A nrPDB Length = 275 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 48/308 (15%), Positives = 116/308 (37%), Gaps = 65/308 (21%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--VKKKKIKREIKILTDL 89 W + +E K+G G++ EV++G + +++ +K LK + ++ +E +I+ L Sbjct: 5 KWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQIMKKL 64 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 + N++ L+ + Sbjct: 65 KH---------------------------------------PNLVQLYGVCTK--EPPIY 83 Query: 150 LVFEYVDNVDFRILY-----PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID 204 ++ EY+ + + + ++ + Y S +HRD+ N ++ Sbjct: 84 IITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLESQNFIHRDLAARNCLVG 143 Query: 205 HKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTML 261 +N +++ D+GLA + + EY R ++F + PE + Y + D+W+FG +L Sbjct: 144 -ENNVVKVADFGLARLINED-EYTARAGAKFPIKWTAPEAI-SYNRFSIKSDVWAFGILL 200 Query: 262 ASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 + + + G S ++ + ++ + Y + P E Y++ + + W++ Sbjct: 201 WEIFTYGQVPYPGMSGSEVIEQVER--------GYRMPRPQGCPEEIYEL---MLQCWNK 249 Query: 322 FINDGNKH 329 + Sbjct: 250 SPEERPTF 257 >3HDN-A nrPDB Length = 373 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 67/343 (19%), Positives = 123/343 (35%), Gaps = 82/343 (23%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 93 D+ +G+G + +V +V +K+L+ K K E I+++ + Sbjct: 34 HAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERN--- 90 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 + H ++ L + V + Sbjct: 91 -----------------------------VLLKNVKHPFLVGLH--FSFQTADKLYFVLD 119 Query: 154 YVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 Y++ + + + RFY E+ AL Y HS+ I++RD+KP N+++D + + Sbjct: 120 YINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQG-HI 178 Query: 211 RLIDWGLAEF-YHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 L D+GL + N + + + PE+L + YD ++D W G +L M++ Sbjct: 179 VLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVL-HKQPYDRTVDWWCLGAVLYEMLYGLP 237 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 PF+ + NT ++ D + KP N N Sbjct: 238 PFY--SRNTAEMY-----------------------------DNILNKPLQLKPNITNS- 265 Query: 330 LSGNDEIIDLIDNLLRYDHQERLTAK----EAMGHPWFAPIRE 368 L++ LL+ D +RL AK E H +F+ I Sbjct: 266 ------ARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINW 302 >5O2B-A nrPDB Length = 285 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 61/353 (17%), Positives = 134/353 (37%), Gaps = 89/353 (25%) Query: 25 DYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVI-----KMLKPVKKKKI 79 + E + S + + + + ++GRG + V++G+ ++ V++ + L ++++ Sbjct: 3 EAEMKAVATSPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRF 62 Query: 80 KREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDI 139 K E ++L L H NI+ +D Sbjct: 63 KEEAEMLKGLQ---------------------------------------HPNIVRFYDS 83 Query: 140 IKD--PISKTPALVFEYVDNVDFRILYPKLTDLE---IRFYMFELLKALDYCHSMG--IM 192 + K LV E + + + + ++ +R + ++LK L + H+ I+ Sbjct: 84 WESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPII 143 Query: 193 HRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSL 252 HRD+K N+ I +++ D GLA + +V + + F PE+ ++ YD S+ Sbjct: 144 HRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSV-IGTPEFMAPEMYEEH--YDESV 200 Query: 253 DLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMD 312 D+++FG + M P+ + K+ + + F K Sbjct: 201 DVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKV---------------- 244 Query: 313 QYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 + E+ ++I+ +R + ERL+ ++ + H +FA Sbjct: 245 -------------------TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 278 >1KOB-A nrPDB Length = 387 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 72/333 (21%), Positives = 127/333 (38%), Gaps = 84/333 (25%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK---PVKKKKIKREIKILTDLSNEKVPP 96 Y+I ++G G + V + V+ + V K + P+ K +K EI I+ L Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVKNEISIMNQLH------ 106 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 H +I+L D +D L+ E++ Sbjct: 107 ---------------------------------HPKLINLHDAFEDKYE--MVLILEFLS 131 Query: 157 NVDFRILYP----KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI-DHKNKKLR 211 + K+++ E+ YM + + L + H I+H D+KP N+M K ++ Sbjct: 132 GGELFDRIAAEDYKMSEAEVINYMRQACEGLKHMHEHSIVHLDIKPENIMCETKKASSVK 191 Query: 212 LIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 +ID+GLA + + V A+ F PE +VD + D+W+ G + ++ PF Sbjct: 192 IIDFGLATKLNPDEIVKVTTATAEFAAPE-IVDREPVGFYTDMWAIGVLGYVLLSGLSPF 250 Query: 272 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLS 331 G + + L Q +++ F D + S Sbjct: 251 -AGEDDLETL-------------------------------QNVKRCDWEF--DEDAFSS 276 Query: 332 GNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + E D I NLL+ + ++RLT +A+ HPW Sbjct: 277 VSPEAKDFIKNLLQKEPRKRLTVHDALEHPWLK 309 >4KS7-A nrPDB Length = 292 Score = 198 bits (502), Expect = 4e-51, Method: Composition-based stats. Identities = 61/349 (17%), Positives = 133/349 (38%), Gaps = 84/349 (24%) Query: 21 EEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK-- 78 E++ V+D + K+G G V + S ++ +KM+ K+++ Sbjct: 6 EQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRE 65 Query: 79 -IKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLF 137 + E+ I+ D H N++ ++ Sbjct: 66 LLFNEVVIMRDYQ---------------------------------------HFNVVEMY 86 Query: 138 DIIKDPISKTPALVFEYVDNVDF--RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRD 195 + + ++ E++ + +L + +I +L+AL Y H+ G++HRD Sbjct: 87 KSYL--VGEELWVLMEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRD 144 Query: 196 VKPHNVMIDHKNKKLRLIDWGLAEFYHVN-MEYNVRVASRFFKGPELLVDYRMYDYSLDL 254 +K ++++ + +++L D+G + + V + ++ PE++ +Y +D+ Sbjct: 145 IKSDSILLTL-DGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVI-SRSLYATEVDI 202 Query: 255 WSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQY 314 WS G M+ M+ P+F +D V+ +K L S K +++ Sbjct: 203 WSLGIMVIEMVDGEPPYF-----SDSPVQAMKRLRDSPPPKLKNSHKV------------ 245 Query: 315 IRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + + D ++ +L D QER TA+E + HP+ Sbjct: 246 ------------------SPVLRDFLERMLVRDPQERATAQELLDHPFL 276 >2R2P-A nrPDB Length = 295 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 72/347 (20%), Positives = 127/347 (36%), Gaps = 76/347 (21%) Query: 20 TEEYWDYENTVIDW--STNTKDYEIENKVGRGKYSEVFQGVKLDSKVK---IVIKMLKPV 74 Y D V ++ IE +G G++ EV G + + IK LK Sbjct: 2 PHTYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVG 61 Query: 75 KKKKIKR----EIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGH 130 +K +R E I+ H Sbjct: 62 YTEKQRRDFLGEASIMGQ---------------------------------------FDH 82 Query: 131 ANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK----LTDLEIRFYMFELLKALDYC 186 NIIHL ++ SK +V EY++N K T +++ + + + Y Sbjct: 83 PNIIHLEGVVTK--SKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGISAGMKYL 140 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME--YNVRVASRF--FKGPELL 242 MG +HRD+ N++I+ N ++ D+GL+ + E Y R + PE + Sbjct: 141 SDMGYVHRDLAARNILINS-NLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAI 199 Query: 243 VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEI 302 +R + + D+WS+G ++ ++ E + +N D + + E Y L + Sbjct: 200 A-FRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAV--------EEGYRLPSPM 250 Query: 303 TLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQ 349 P Y Q + W + N K DEI++++D L+R + Sbjct: 251 DCPAALY---QLMLDCWQKERNSRPKF----DEIVNMLDKLIR-NPA 289 >3RAW-A nrPDB Length = 381 Score = 196 bits (499), Expect = 9e-51, Method: Composition-based stats. Identities = 73/369 (19%), Positives = 150/369 (40%), Gaps = 67/369 (18%) Query: 30 VIDWSTNTKDYEIENKVGRGKYSEVFQGVKL-DSKVKIVIKMLKPVKK--KKIKREIKIL 86 + DW + YEI +G G + +V + + K ++ +K+++ V K + + EI +L Sbjct: 45 IGDWL--QERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVL 102 Query: 87 TDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISK 146 + + L ++ H ++ F+++ Sbjct: 103 KKIKEKDKENKFLCVLMSDWFNF--------------------HGHMCIAFELLGKNT-- 140 Query: 147 TPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI--- 203 FE++ +F +R ++L AL + H + H D+KP N++ Sbjct: 141 -----FEFLKENNF----QPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNS 191 Query: 204 ---------------DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMY 248 KN +R+ D+G A F H + + VA+R ++ PE++++ + Sbjct: 192 EFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEH--HTTIVATRHYRPPEVILEL-GW 248 Query: 249 DYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGT--------SDFEKYLLKY 300 D+WS G +L ++ F N + LV + K+LG + +KY K Sbjct: 249 AQPCDVWSIGCILFEY-YRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKG 307 Query: 301 EITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGH 360 + D +Y+++ + + + ++ DL+ +L +D +R+T EA+ H Sbjct: 308 GLVWDENSSD-GRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLH 366 Query: 361 PWFAPIREQ 369 P+FA + + Sbjct: 367 PFFAGLTPE 375 >2Z7Q-A nrPDB Length = 321 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 62/343 (18%), Positives = 129/343 (37%), Gaps = 84/343 (24%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVP 95 + +E+ +G+G + +VF K+ + +K +KK +K ++ T + + + Sbjct: 26 DPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILA 85 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 H ++ L L+ +++ Sbjct: 86 DVN-------------------------------HPFVVKLHYAF--QTEGKLYLILDFL 112 Query: 156 DNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRL 212 D K T+ +++FY+ EL LD+ HS+GI++RD+KP N+++D + ++L Sbjct: 113 RGGDLFTRLSKEVMFTEEDVKFYLAELALGLDHLHSLGIIYRDLKPENILLDEEG-HIKL 171 Query: 213 IDWGLAEFYHVNMEY-NVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 D+GL++ + + + + PE++ + + + +S D WS+G ++ M+ PF Sbjct: 172 TDFGLSKEAIDHEKKAYSFCGTVEYMAPEVV-NRQGHSHSADWWSYGVLMFEMLTGSLPF 230 Query: 272 FHGTSNTDQLVKIVKV-LGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 330 G + + I+K LG F Sbjct: 231 -QGKDRKETMTLILKAKLGMPQF------------------------------------- 252 Query: 331 SGNDEIIDLIDNLLRYDHQERL-----TAKEAMGHPWFAPIRE 368 + E L+ L + + RL A+E H +++ I Sbjct: 253 -LSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDW 294 >4PWN-A nrPDB Length = 274 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 58/349 (16%), Positives = 128/349 (36%), Gaps = 88/349 (25%) Query: 29 TVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVI-----KMLKPVKKKKIKREI 83 + S + + + + ++GRG + V++G+ ++ V++ + L ++++ K E Sbjct: 1 KAVGMSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEA 60 Query: 84 KILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP 143 ++L L H NI+ +D + Sbjct: 61 EMLKGLQ---------------------------------------HPNIVRFYDSWEST 81 Query: 144 I--SKTPALVFEYVDNVDFRILYPKLTDLEI---RFYMFELLKALDYCHSMG--IMHRDV 196 + K LV E + + + + ++I R + ++LK L + H+ I+HRD+ Sbjct: 82 VKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHTRTPPIIHRDL 141 Query: 197 KPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWS 256 K N+ I +++ D GLA + + F PE+ + YD S+D+++ Sbjct: 142 KCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPEMYEE--KYDESVDVYA 199 Query: 257 FGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIR 316 FG + M P+ + ++ + + F+K + Sbjct: 200 FGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAI------------------ 241 Query: 317 KPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 E+ ++I+ +R + ER + K+ + H +F Sbjct: 242 -----------------PEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >5N23-A nrPDB Length = 352 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 62/376 (16%), Positives = 136/376 (36%), Gaps = 90/376 (23%) Query: 7 SEARVYTNINKQRTEEYWDYENTVIDWSTNTKD------YEIENKVGRGKYSEVFQGVKL 60 + A+ + + E+ + W + ++ +E +G G + V Sbjct: 5 AAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIRTLGTGSFGRVMLVKHK 64 Query: 61 DSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRP 120 ++ +K+L K K+K +I L+ +++ Sbjct: 65 ETGNHYAMKILDKQKVVKLK---QIEHTLNEKRIQQAVNF-------------------- 101 Query: 121 YIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILY---PKLTDLEIRFYMF 177 ++ L KD + +V EY + + ++ RFY Sbjct: 102 ----------PFLVKLEFSFKDNSN--LYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAA 149 Query: 178 ELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFK 237 +++ +Y HS+ +++RD+KP N++ID + +++ D+G A+ + + + Sbjct: 150 QIVLTFEYLHSLDLIYRDLKPENLLIDQQGY-IKVADFGFAKRVKGRTPWT-LCGTPEYL 207 Query: 238 GPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYL 297 PE+++ + Y+ ++D W+ G ++ M PFF DQ ++I + + Sbjct: 208 APEIILS-KGYNKAVDWWALGVLIYEMAAGYPPFF-----ADQPIQIYEKI--------- 252 Query: 298 LKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERL----- 352 + ++ P F + ++ DL+ NLL+ D +R Sbjct: 253 VSGKVRFPSHF------------------------SSDLKDLLRNLLQVDLTKRFGNLKN 288 Query: 353 TAKEAMGHPWFAPIRE 368 + H WFA Sbjct: 289 GVNDIKNHKWFATTDW 304 >5UNP-A nrPDB Length = 369 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 75/371 (20%), Positives = 155/371 (41%), Gaps = 69/371 (18%) Query: 29 TVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLD-SKVKIVIKMLKPVKK--KKIKREIKI 85 V DW + YEI + +G G + V Q V ++ +K++K V+K + + EI + Sbjct: 27 HVGDWL--QERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINV 84 Query: 86 LTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANI-IHLFDIIKDPI 144 L ++ + L Q ++ ++GH I L + Sbjct: 85 LEKINEKDPDNKNLCVQMFDWF------------------DYHGHMCISFELLGLST--- 123 Query: 145 SKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI- 203 F+++ + ++ ++R F+L +A+ + H + H D+KP N++ Sbjct: 124 -------FDFLKDNNYLPY----PIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFV 172 Query: 204 -----------------DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYR 246 K+ +R++D+G A F H + ++ V++R ++ PE++++ Sbjct: 173 NSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEH--HSTIVSTRHYRAPEVILEL- 229 Query: 247 MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGT--------SDFEKYLL 298 + D+WS G ++ F N + L + ++LG + +KY Sbjct: 230 GWSQPCDVWSIGCIIFEYYVGFT-LFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFY 288 Query: 299 KYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAM 358 + + E +Y+R+ + ++ DLI+++L Y+ +RLT EA+ Sbjct: 289 RGRLDW-DENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEAL 347 Query: 359 GHPWFAPIREQ 369 HP+FA +R + Sbjct: 348 QHPFFARLRAE 358 >5DYK-A nrPDB Length = 853 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 72/348 (20%), Positives = 127/348 (36%), Gaps = 82/348 (23%) Query: 29 TVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTD 88 + D + E E +GRG + V +K++ +K + + ++ I Sbjct: 530 KMQDTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNI--- 586 Query: 89 LSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTP 148 + N H II L KD SK Sbjct: 587 ------------------------------KLEREITAENDHPFIIRLVRTFKD--SKYF 614 Query: 149 ALVFEYVDNVDFRILYPKL---TDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 + E V + KL + + +FY+ ++ A++Y H I++RD+KP N+++D Sbjct: 615 YFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDK 674 Query: 206 KNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 + ++LID+G A+ V V + + PE+++ + Y ++D+W+ G L I Sbjct: 675 QGY-VKLIDFGCAK--KVQGRAYTLVGTPHYMAPEVILG-KGYGCTVDIWALGICLYEFI 730 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 PF G DQL +I + + T ++T P D D Sbjct: 731 CGPLPF--GNDEEDQL-EIFRDILT---------GQLTFPDYVTDTDS------------ 766 Query: 326 GNKHLSGNDEIIDLIDNLLRYDHQERLTA-----KEAMGHPWFAPIRE 368 I+L+ LL Q R+ K+ HP+F+ Sbjct: 767 -----------INLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSNFNW 803 >1VZO-A nrPDB Length = 355 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 62/345 (17%), Positives = 126/345 (36%), Gaps = 76/345 (22%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKV 94 +++E+ +G G Y +VF K+ + +K +KK I ++ K E+ Sbjct: 51 VGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQ 110 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 + ++ L L+ +Y Sbjct: 111 VLEHIRQS----------------------------PFLVTLHYAF--QTETKLHLILDY 140 Query: 155 VDNVDFRIL---YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 ++ + + T+ E++ Y+ E++ AL++ H +GI++RD+K N+++D N + Sbjct: 141 INGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDS-NGHVV 199 Query: 212 LIDWGLAEFYHVNMEYNV--RVASRFFKGPELLVDY-RMYDYSLDLWSFGTMLASMIFKR 268 L D+GL++ + + + + P+++ +D ++D WS G ++ ++ Sbjct: 200 LTDFGLSKEFVADETERAYDFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGA 259 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 PF Q ++ + +LK E P+E Sbjct: 260 SPFTVDGEKNSQ----------AEISRRILKSEPPYPQEM-------------------- 289 Query: 329 HLSGNDEIIDLIDNLLRYDHQERL-----TAKEAMGHPWFAPIRE 368 + DLI LL D ++RL A E H +F I Sbjct: 290 ----SALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINW 330 >4B8L-A nrPDB Length = 286 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 71/331 (21%), Positives = 126/331 (38%), Gaps = 79/331 (23%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKV 94 D++I +G+GK+ V+ + +K + +K+L + +K Sbjct: 12 FTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEK---------------- 55 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 E V +R I Q H H NI+ +++ D K L+ E+ Sbjct: 56 -----------------EGVEHQLRREIEIQSHLRHPNILRMYNYFHD--RKRIYLMLEF 96 Query: 155 VDNVDFR---ILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 + + + + +M EL AL YCH ++HRD+KP N+++ +K +L+ Sbjct: 97 APRGELYKELQKHGRFDEQRSATFMEELADALHYCHERKVIHRDIKPENLLMGYKG-ELK 155 Query: 212 LIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 + D+G + + ++ + + PE++ + + +D +DLW G + + PF Sbjct: 156 IADFGWS-VHAPSLRRRTMCGTLDYLPPEMI-EGKTHDEKVDLWCAGVLCYEFLVGMPPF 213 Query: 272 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLS 331 S+T+ +IV V D Sbjct: 214 -DSPSHTETHRRIVNV-------------------------------------DLKFPPF 235 Query: 332 GNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 +D DLI LLRY +RL K M HPW Sbjct: 236 LSDGSKDLISKLLRYHPPQRLPLKGVMEHPW 266 >4AF3-A nrPDB Length = 292 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 75/332 (22%), Positives = 127/332 (38%), Gaps = 79/332 (23%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 93 D+EI +G+GK+ V+ + S + +K+L K +I Sbjct: 19 HFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVL-------FKSQI---------- 61 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 +KE V +R I Q H H NI+ L++ D + L+ E Sbjct: 62 ----------------EKEGVEHQLRREIEIQAHLHHPNILRLYNYFYD--RRRIYLILE 103 Query: 154 YVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 Y + K + M EL AL YCH ++HRD+KP N+ + +L Sbjct: 104 YAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENL-LLGLKGEL 162 Query: 211 RLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 ++ D+G + + ++ + + PE++ + RM++ +DLW G + ++ P Sbjct: 163 KIADFGWS-VHAPSLRRKTMCGTLDYLPPEMI-EGRMHNEKVDLWCIGVLCYELLVGNPP 220 Query: 271 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 330 F S+ + +IVKV LK+ ++P Sbjct: 221 F-ESASHNETYRRIVKV---------DLKFPASVPTG----------------------- 247 Query: 331 SGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 DLI LLR++ ERL + HPW Sbjct: 248 -----AQDLISKLLRHNPSERLPLAQVSAHPW 274 >3Q53-A nrPDB Length = 306 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 60/350 (17%), Positives = 128/350 (36%), Gaps = 84/350 (24%) Query: 21 EEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK---PVKKK 77 EE + +++ K Y K+G+G V+ + + + ++ I+ + KK+ Sbjct: 4 EEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKE 63 Query: 78 KIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLF 137 I EI ++ + N NI++ Sbjct: 64 LIINEILVMRENKN---------------------------------------PNIVNYL 84 Query: 138 DIIKDPISKTPALVFEYVDNVDFRILYPK--LTDLEIRFYMFELLKALDYCHSMGIMHRD 195 D + +V EY+ + + + + +I E L+AL++ HS ++HRD Sbjct: 85 DSYL--VGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRD 142 Query: 196 VKPHNVMIDHKNKKLRLIDWGL-AEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDL 254 +K N+++ + ++L D+G A+ + + V + ++ PE++ + Y +D+ Sbjct: 143 IKSDNILLG-MDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVV-TRKAYGPKVDI 200 Query: 255 WSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQY 314 WS G M MI P+ + N + + ++ GT + + Sbjct: 201 WSLGIMAIEMIEGEPPYLN--ENPLRALYLIATNGTPELQN------------------- 239 Query: 315 IRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + D ++ L D ++R +AKE + H + Sbjct: 240 --------------PEKLSAIFRDFLNRCLEMDVEKRGSAKELIQHQFLK 275 >5UUU-A nrPDB Length = 547 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 70/365 (19%), Positives = 135/365 (36%), Gaps = 79/365 (21%) Query: 15 INKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPV 74 I + + ++N ++ D+ + +GRG + EV+ K D+ +K L Sbjct: 175 IESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKK 234 Query: 75 KKKKIKREIKILTD-LSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANI 133 + K + E L + + V PF Y D L F Sbjct: 235 RIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSF---------------- 278 Query: 134 IHLFDIIKDPISKTPALVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMG 190 + + ++ D + ++ ++RFY E++ L++ H+ Sbjct: 279 -----------------ILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRF 321 Query: 191 IMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDY 250 +++RD+KP N+++D ++ +R+ D GLA + + + V + + PE+L YD Sbjct: 322 VVYRDLKPANILLD-EHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQKGVAYDS 379 Query: 251 SLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYD 310 S D +S G ML ++ PF + + ++ L + LP F Sbjct: 380 SADWFSLGCMLFKLLRGHSPFRQHKTKDKH-----------EIDRMTLTMAVELPDSF-- 426 Query: 311 MDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERL-----TAKEAMGHPWFAP 365 + E+ L++ LL+ D RL A+E P+F Sbjct: 427 ----------------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 464 Query: 366 IREQI 370 + Q+ Sbjct: 465 LDWQM 469 >5O2C-A nrPDB Length = 380 Score = 194 bits (492), Expect = 6e-50, Method: Composition-based stats. Identities = 60/344 (17%), Positives = 131/344 (38%), Gaps = 89/344 (25%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVI-----KMLKPVKKKKIKREIKILTD 88 S + + + + ++GRG + V++G+ ++ V++ + L ++++ K E ++L Sbjct: 21 SPSGRFLKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKG 80 Query: 89 LSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD--PISK 146 L H NI+ +D + K Sbjct: 81 LQ---------------------------------------HPNIVRFYDSWESILKGKK 101 Query: 147 TPALVFEYVDNVDFRILYPKLTDLE---IRFYMFELLKALDYCHSMG--IMHRDVKPHNV 201 LV E + + + + ++ +R + ++LK L + H+ I+HRD+K N+ Sbjct: 102 CIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLQFLHTRTPPIIHRDLKCDNI 161 Query: 202 MIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTML 261 I +++ D GLA + +V + + F PE+ ++ YD S+D+++FG + Sbjct: 162 FITGPTGSVKIGDLGLATLMRTSFAKSV-IGTPEFMAPEMYEEH--YDESVDVYAFGMCM 218 Query: 262 ASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 M P+ + K+ + + F K Sbjct: 219 LEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKV------------------------- 253 Query: 322 FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 + E+ ++I+ +R + ERL+ ++ + H +FA Sbjct: 254 ----------TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 287 >5LOH-A nrPDB Length = 341 Score = 194 bits (492), Expect = 7e-50, Method: Composition-based stats. Identities = 63/345 (18%), Positives = 119/345 (34%), Gaps = 84/345 (24%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKV 94 + +++ I + RG + +V+ G K +K++K I +++++ Sbjct: 33 PSIEEFSIVKPISRGAFGKVYLGQK--GGKLYAVKVVKKADM--------INKNMTHQVQ 82 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 I+HL+ ++ + LV EY Sbjct: 83 AERDALALSKS-------------------------PFIVHLYYSLQS--ANNVYLVMEY 115 Query: 155 VDNVD---FRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 + D +Y + Y+ E+ ALDY H GI+HRD+KP N++I ++ ++ Sbjct: 116 LIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEG-HIK 174 Query: 212 LIDWGLAEF-------YHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASM 264 L D+GL++ + + + PELL+ R + ++D W+ G L Sbjct: 175 LTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPELLLG-RAHGPAVDWWALGVCLFEF 233 Query: 265 IFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIN 324 + PF + + I+K R I Sbjct: 234 LTGIPPF-NDETPQQVFQNILK----------------------------------RDIP 258 Query: 325 DGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 +D ++ LL D +R KE HP F+ + + Sbjct: 259 WPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVDWE 303 >4WNO-A nrPDB Length = 287 Score = 193 bits (491), Expect = 9e-50, Method: Composition-based stats. Identities = 67/342 (19%), Positives = 129/342 (37%), Gaps = 93/342 (27%) Query: 39 DYEIENKVGRGKYSEVFQGVKLDSK-VKIVIKMLKPVKKKK----IKREIKILTDLSNEK 93 ++ ++ +G G ++ VF+G + +++ +K + K + +EIKIL +L Sbjct: 19 EFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELK--- 75 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 H NI+ L+D ++ + LV E Sbjct: 76 ------------------------------------HENIVALYDF--QEMANSVYLVME 97 Query: 154 YVDNVDFRILYP---KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK-- 208 Y + D L++ IR ++ ++ A+ HS GI+HRD+KP N+++ + Sbjct: 98 YCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRR 157 Query: 209 ------KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLA 262 ++++ D+G A + NM S + PE+++ + YD DLWS GT++ Sbjct: 158 ANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMS-QHYDGKADLWSIGTIVY 216 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 + + PF +S D F + T+PRE + + + Sbjct: 217 QCLTGKAPF-QASSPQD----------LRLFYEKNKTLVPTIPRETSAPLRQLLLALLQR 265 Query: 323 INDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 +H++R+ E HP+ Sbjct: 266 ------------------------NHKDRMDFDEFFHHPFLD 283 >3PVW-A nrPDB Length = 695 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 70/365 (19%), Positives = 135/365 (36%), Gaps = 79/365 (21%) Query: 15 INKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPV 74 I + + ++N ++ D+ + +GRG + EV+ K D+ +K L Sbjct: 166 IESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKK 225 Query: 75 KKKKIKREIKILTD-LSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANI 133 + K + E L + + V PF Y D L F Sbjct: 226 RIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSF---------------- 269 Query: 134 IHLFDIIKDPISKTPALVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMG 190 + + ++ D + ++ ++RFY E++ L++ H+ Sbjct: 270 -----------------ILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRF 312 Query: 191 IMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDY 250 +++RD+KP N+++D ++ +R+ D GLA + + + V + + PE+L YD Sbjct: 313 VVYRDLKPANILLD-EHGHVRISDLGLACDFS-KKKPHASVGTHGYMAPEVLQKGVAYDS 370 Query: 251 SLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYD 310 S D +S G ML ++ PF + + ++ L + LP F Sbjct: 371 SADWFSLGCMLFKLLRGHSPFRQHKTKDKH-----------EIDRMTLTMAVELPDSF-- 417 Query: 311 MDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERL-----TAKEAMGHPWFAP 365 + E+ L++ LL+ D RL A+E P+F Sbjct: 418 ----------------------SPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRS 455 Query: 366 IREQI 370 + Q+ Sbjct: 456 LDWQM 460 >3DKO-A nrPDB Length = 318 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 66/349 (18%), Positives = 128/349 (36%), Gaps = 78/349 (22%) Query: 19 RTEEYWDYENTVIDW--STNTKDYEIENKVGRGKYSEVFQGVKLDSKVK---IVIKMLKP 73 E Y D V + + +IE +G G++ EV G + + IK LK Sbjct: 22 DPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKV 81 Query: 74 VKKKKIKR----EIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNG 129 +K +R E I+ Sbjct: 82 GYTEKQRRDFLCEASIMGQ---------------------------------------FD 102 Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDF----RILYPKLTDLEIRFYMFELLKALDY 185 H N++HL ++ K +V E+++N R + T +++ + + + Y Sbjct: 103 HPNVVHLEGVVTR--GKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRY 160 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME--YNVRVASRF--FKGPEL 241 MG +HRD+ N++++ N ++ D+GL+ + E Y + PE Sbjct: 161 LADMGYVHRDLAARNILVNS-NLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEA 219 Query: 242 LVDYRMYDYSLDLWSFGTMLAS-MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 300 + YR + + D+WS+G ++ M + P++ SN D + I E Y L Sbjct: 220 IQ-YRKFTSASDVWSYGIVMWEVMSYGERPYWD-MSNQDVIKAI--------EEGYRLPA 269 Query: 301 EITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQ 349 + P + Q + W + + K ++I+ ++D ++R + Sbjct: 270 PMDCPAGLH---QLMLDCWQKERAERPKF----EQIVGILDKMIR-NPN 310 >6QAU-A nrPDB Length = 280 Score = 193 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 66/302 (21%), Positives = 120/302 (39%), Gaps = 58/302 (19%) Query: 39 DYEIENKVGRGKYSEVFQGVKL-DSKVKIVIKMLKPVKKKK----IKREIKILTDLSNEK 93 +Y + VG G ++ VF+G + ++ IK + K + +EIKIL +L Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQ--- 68 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 H NI+ L+D+ + P + LV E Sbjct: 69 ------------------------------------HENIVALYDVQELP--NSVFLVME 90 Query: 154 YVDNVDFRILYP---KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK-- 208 Y + D L++ IR ++ ++ A+ HS GI+HRD+KP N+++ + N+ Sbjct: 91 YCNGGDLADYLQAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRK 150 Query: 209 ------KLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLA 262 ++++ D+G A + H NM S + PE+++ + YD DLWS GT++ Sbjct: 151 SSVSGIRIKIADFGFARYLHSNMMAADLCGSPMYMAPEVIMS-QHYDAKADLWSIGTVIY 209 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 + + PF + ++ + Y L +Q R + F Sbjct: 210 QCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAF 269 Query: 323 IN 324 + Sbjct: 270 FS 271 >3A8W-A nrPDB Length = 345 Score = 193 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 68/343 (19%), Positives = 128/343 (37%), Gaps = 79/343 (23%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 +D+++ +GRG Y++V + +K++K +L N+ Sbjct: 9 QDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVK--------------KELVND----- 49 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 ED+ + + H ++ L V EYV+ Sbjct: 50 -------------DEDIDWVQTEKHVFEQASNHPFLVGLHSCF--QTESRLFFVIEYVNG 94 Query: 158 VDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLID 214 D + L + RFY E+ AL+Y H GI++RD+K NV++D + ++L D Sbjct: 95 GDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEG-HIKLTD 153 Query: 215 WGLAEF-YHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF-- 271 +G+ + + + + PE+L Y +S+D W+ G ++ M+ R PF Sbjct: 154 YGMCKEGLRPGDTTSTFCGTPNYIAPEILRG-EDYGFSVDWWALGVLMFEMMAGRSPFDI 212 Query: 272 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLS 331 + N DQ + + +L+ +I +PR S Sbjct: 213 VGSSDNPDQNTE-------DYLFQVILEKQIRIPR------------------------S 241 Query: 332 GNDEIIDLIDNLLRYDHQERLTA------KEAMGHPWFAPIRE 368 + + ++ + L D +ERL + GHP+F + Sbjct: 242 LSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDW 284 >4P5Q-A nrPDB Length = 361 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 74/328 (22%), Positives = 126/328 (38%), Gaps = 61/328 (18%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 93 + + I+ VG G++ EV G LK KK+I IK L Sbjct: 29 ELDATNISIDKVVGAGEFGEVCSGR------------LKLPSKKEISVAIKTLK------ 70 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 Y Q+ D L H NII L ++ SK +V E Sbjct: 71 ----------VGYTEKQRRDFLG----EASIMGQFDHPNIIRLEGVVTK--SKPVMIVTE 114 Query: 154 YVDNVDFRILYPK----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 Y++N K T +++ + + + Y MG +HRD+ N++I+ N Sbjct: 115 YMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINS-NLV 173 Query: 210 LRLIDWGLAEFYHVNME--YNVRVASRF--FKGPELLVDYRMYDYSLDLWSFGTMLAS-M 264 ++ D+GL+ + E Y R + PE + YR + + D+WS+G +L M Sbjct: 174 CKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTSPEAIA-YRKFTSASDVWSYGIVLWEVM 232 Query: 265 IFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIN 324 + P++ SN D + + E Y L + P Y Q + W + N Sbjct: 233 SYGERPYW-EMSNQDVIKAV--------DEGYRLPPPMDCPAALY---QLMLDCWQKDRN 280 Query: 325 DGNKHLSGNDEIIDLIDNLLRYDHQERL 352 + K ++I+ ++D L+R ++ Sbjct: 281 NRPKF----EQIVSILDKLIRNPGSLKI 304 >6E2O-A nrPDB Length = 295 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 64/360 (17%), Positives = 118/360 (32%), Gaps = 91/360 (25%) Query: 18 QRTEEYWDYENTVIDWSTNTKDYEIEN-----KVGRGKYSEVFQGVKLDSKVKIVIKMLK 72 R+ E D E+ ++++ DYE + +G+G Y V+ G L ++V+I IK + Sbjct: 2 SRSTEEGDCESDLLEY-----DYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEI- 55 Query: 73 PVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHAN 132 + + + I H H N Sbjct: 56 -----------------------------------PERDSRYSQPLHEEIALHKHLKHKN 80 Query: 133 IIHLFDIIKDPISKTPALVFEYVDNVDFRILYP------KLTDLEIRFYMFELLKALDYC 186 I+ + + + E V L K + I FY ++L+ L Y Sbjct: 81 IVQYLGSFSE--NGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYL 138 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFY-HVNMEYNVRVASRFFKGPELL-VD 244 H I+HRD+K NV+I+ + L++ D+G ++ +N + + PE++ Sbjct: 139 HDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKG 198 Query: 245 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 R Y + D+WS G + M + PF+ + K+ + K + Sbjct: 199 PRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKV-----------GMFKVHPEI 247 Query: 305 PREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 P + E I D +R A + + + Sbjct: 248 PESM------------------------SAEAKAFILKCFEPDPDKRACANDLLVDEFLK 283 >4WB7-A nrPDB Length = 405 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 63/356 (17%), Positives = 132/356 (37%), Gaps = 91/356 (25%) Query: 27 ENTVIDWSTNTKD------YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIK 80 E+ + W + ++ +E +G G + V ++ +K+L K K+K Sbjct: 79 EDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLK 138 Query: 81 REIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII 140 +I L+ +++ ++ L Sbjct: 139 ---QIEHTLNEKRILQAVNF------------------------------PFLVKLEFSF 165 Query: 141 KDPISKTPALVFEYVDNVDFRILY---PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVK 197 KD + +V EYV + + ++ RFY +++ +Y HS+ +++RD+K Sbjct: 166 KDNSN--LYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLK 223 Query: 198 PHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSF 257 P N++ID + +++ D+G A+ V + + PE+++ + Y+ ++D W+ Sbjct: 224 PENLLIDQQGY-IQVTDFGFAK--RVKGRTWTLCGTPEYLAPEIILS-KGYNKAVDWWAL 279 Query: 258 GTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRK 317 G ++ M PFF DQ ++I + + + ++ P F Sbjct: 280 GVLIYEMAAGYPPFF-----ADQPIQIYEKI---------VSGKVRFPSHF--------- 316 Query: 318 PWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERL-----TAKEAMGHPWFAPIRE 368 + ++ DL+ NLL+ D +R + H WFA Sbjct: 317 ---------------SSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDW 357 >3DB8-A nrPDB Length = 317 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 61/380 (16%), Positives = 132/380 (34%), Gaps = 99/380 (26%) Query: 3 CRVWSEARVYTNINKQRTEEYWDYENTVIDWSTN-------TKDYEIENKVGRGKYSEVF 55 + S + + + D ++ + + K Y +G+G +++ + Sbjct: 1 GPLGSMSAAIAK-PSAKPSAHVDPKSAPLKEIPDVLVDPRTMKRYMRGRFLGKGGFAKCY 59 Query: 56 QGVKLDSKVKIVIKM------LKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTN 109 + +D+K K+ LKP +K+K+ EI I L N Sbjct: 60 EITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDN------------------ 101 Query: 110 QKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK--- 166 +++ +D +V E L+ + Sbjct: 102 ---------------------PHVVGFHGFFED--DDFVYVVLEICRRRSLLELHKRRKA 138 Query: 167 LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME 226 +T+ E R++M + ++ + Y H+ ++HRD+K N+ ++ + +++ D+GLA + E Sbjct: 139 VTEPEARYFMRQTIQGVQYLHNNRVIHRDLKLGNLFLN-DDMDVKIGDFGLATKIEFDGE 197 Query: 227 Y-NVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIV 285 + + PE+L + + + +D+WS G +L +++ + PF Sbjct: 198 RKKDLCGTPNYIAPEVLCK-KGHSFEVDIWSLGCILYTLLVGKPPF-------------- 242 Query: 286 KVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLR 345 + + + K E ++PR N LI +L Sbjct: 243 ETSCLKETYIRIKKNEYSVPRHI------------------------NPVASALIRRMLH 278 Query: 346 YDHQERLTAKEAMGHPWFAP 365 D R + E + +F Sbjct: 279 ADPTLRPSVAELLTDEFFTS 298 >5FET-A nrPDB Length = 847 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 73/348 (20%), Positives = 126/348 (36%), Gaps = 82/348 (23%) Query: 29 TVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTD 88 + D + E E +GRG + V ++++ +K + KR I L Sbjct: 524 KMQDTKVEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVS-------KRSIISLNQ 576 Query: 89 LSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTP 148 +N I+ N H II L KD S Sbjct: 577 QNN--------------------------IKLEREITAENDHPFIIRLVRTFKD--SNCF 608 Query: 149 ALVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 + E V + K L+ + +FY+ ++ A++Y H I++RD+KP N+++D Sbjct: 609 YFLTELVTGGELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDK 668 Query: 206 KNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 + ++LID+G A+ V + + PE+++ + Y ++D+W+ G L I Sbjct: 669 QGY-VKLIDFGCAKKIQ--GRAYTLVGTPHYMAPEVILG-KGYGCTVDIWALGVCLYEFI 724 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 PF G DQL +I + + T ++T P D D Sbjct: 725 CGPLPF--GNDQEDQL-EIFRDILT---------GQLTFPDYVSDQDS------------ 760 Query: 326 GNKHLSGNDEIIDLIDNLLRYDHQERLTA-----KEAMGHPWFAPIRE 368 I+L+ LL Q R+ K+ H +F Sbjct: 761 -----------INLMKRLLCRLPQGRIGCSINGFKDIKEHAFFGNFNW 797 >6CCF-A nrPDB Length = 290 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 56/334 (16%), Positives = 119/334 (35%), Gaps = 52/334 (15%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 93 S Y++++++G+G Y V +K+L K + Sbjct: 1 SMQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLL---------KQYGFPR 51 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 PP Q L+ + I H N++ L +++ DP LVF+ Sbjct: 52 RPPPRGSQAAQGGPAKQLL-PLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFD 110 Query: 154 YVDNVDFRIL--YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 + + ++ + R Y+ +++ L+Y H I+HRD+KP N+++ + ++ Sbjct: 111 LLRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLG-DDGHVK 169 Query: 212 LIDWGLAEFYHV-NMEYNVRVASRFFKGPELL--VDYRMYDYSLDLWSFGTMLASMIFKR 268 + D+G++ + + + + + F PE + +LD+W+ G L ++ + Sbjct: 170 IADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGK 229 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 PF D + + + Sbjct: 230 CPF------------------------------------IDDFILALHRKIKNEPVVFPE 253 Query: 329 HLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 ++E+ DLI +L + + R+ + HPW Sbjct: 254 EPEISEELKDLILKMLDKNPETRIGVPDIKLHPW 287 >5DBX-A nrPDB Length = 328 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 55/361 (15%), Positives = 117/361 (32%), Gaps = 91/361 (25%) Query: 30 VIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKK----KIKREIKI 85 + W YE++ +G G + V + + ++ IK + K + ++ +EI+ Sbjct: 3 AVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQA 62 Query: 86 LTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPIS 145 ++ S+ N++ + + Sbjct: 63 MSQCSH---------------------------------------PNVVTYYTSF--VVK 81 Query: 146 KTPALVFEYVDNVDFRILYPK-----------LTDLEIRFYMFELLKALDYCHSMGIMHR 194 LV + + + L + I + E+L+ LDY H G +HR Sbjct: 82 DELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHR 141 Query: 195 DVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME------YNVRVASRFFKGPELLVDYRMY 248 D+K N+++ ++ +++ D+G++ F + V + + PE++ R Y Sbjct: 142 DLKAGNILLG-EDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGTPCWMAPEVMEQVRGY 200 Query: 249 DYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREF 308 D+ D+WSFG + P+ + +L + P Sbjct: 201 DFKADMWSFGITAIELATGAAPYH----------------KYPPMKVLMLTLQNDPPT-- 242 Query: 309 YDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 368 + D L+ L+ D +R TA E + +F + Sbjct: 243 ----------LETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKN 292 Query: 369 Q 369 + Sbjct: 293 R 293 >4RA4-A nrPDB Length = 355 Score = 191 bits (486), Expect = 4e-49, Method: Composition-based stats. Identities = 57/341 (16%), Positives = 116/341 (34%), Gaps = 83/341 (24%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 D+ +G+G + +V + ++ IK+LK Sbjct: 20 TDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKD----------------------- 56 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 Q +DV + + + L V EYV+ Sbjct: 57 ---------VVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCF--QTVDRLYFVMEYVNG 105 Query: 158 VDFRILYP---KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLID 214 D K + + FY E+ L + H GI++RD+K NVM+D + +++ D Sbjct: 106 GDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEG-HIKIAD 164 Query: 215 WGLAEFYHVNM-EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFH 273 +G+ + + ++ + + PE++ Y+ Y S+D W++G +L M+ + PF Sbjct: 165 FGMCKEHMMDGVTTRTFCGTPDYIAPEIIA-YQPYGKSVDWWAYGVLLYEMLAGQPPF-D 222 Query: 274 GTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGN 333 G + I++ + ++ P+ S + Sbjct: 223 GEDEDELFQSIME-------------HNVSYPK------------------------SLS 245 Query: 334 DEIIDLIDNLLRYDHQERLTA-----KEAMGHPWFAPIREQ 369 E + + L+ +RL ++ H +F I + Sbjct: 246 KEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWE 286 >2OU7-A nrPDB Length = 335 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 58/330 (17%), Positives = 122/330 (36%), Gaps = 91/330 (27%) Query: 46 VGRGKYSEVFQGVKLDSKVKIVIKM------LKPVKKKKIKREIKILTDLSNEKVPPTTL 99 +G+G +++ F+ D+K K+ LKP +++K+ EI I L Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSL---------- 98 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVD 159 H +++ +D + +V E Sbjct: 99 -----------------------------AHQHVVGFHGFFED--NDFVFVVLELCRRRS 127 Query: 160 FRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWG 216 L+ + LT+ E R+Y+ +++ Y H ++HRD+K N+ ++ ++ ++++ D+G Sbjct: 128 LLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEVKIGDFG 186 Query: 217 LAEFYHVNMEY-NVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGT 275 LA + E V + + PE+L + + + +D+WS G ++ +++ + PF Sbjct: 187 LATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEVDVWSIGCIMYTLLVGKPPF---- 241 Query: 276 SNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDE 335 + + + K E ++P+ N Sbjct: 242 ----------ETSCLKETYLRIKKNEYSIPKHI------------------------NPV 267 Query: 336 IIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 LI +L+ D R T E + +F Sbjct: 268 AASLIQKMLQTDPTARPTINELLNDEFFTS 297 >3ORZ-A nrPDB Length = 316 Score = 191 bits (484), Expect = 5e-49, Method: Composition-based stats. Identities = 72/344 (20%), Positives = 132/344 (38%), Gaps = 87/344 (25%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 +D++ +G G +S V +L + + IK+L +K+ I +E K+ Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKIL---EKRHIIKENKV------------ 81 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 Y ++ DV+ + H + L+ +D + Y N Sbjct: 82 --------PYVTRERDVMSRL----------DHPFFVKLYFCFQD--DEKLYFGLSYAKN 121 Query: 158 VDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLID 214 + K + RFY E++ AL+Y H GI+HRD+KP N++++ ++ +++ D Sbjct: 122 GELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLN-EDMHIQITD 180 Query: 215 WGLAEFYHVNME---YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 +G A+ + N V + + PELL + S DLW+ G ++ ++ PF Sbjct: 181 FGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSAC-KSSDLWALGCIIYQLVAGLPPF 239 Query: 272 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLS 331 G KI+K+ E P +F+ Sbjct: 240 RAGNEYL-IFQKIIKL-------------EYDFPEKFF---------------------- 263 Query: 332 GNDEIIDLIDNLLRYDHQERLTAKE------AMGHPWFAPIREQ 369 + DL++ LL D +RL +E HP+F + + Sbjct: 264 --PKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWE 305 >4QMW-A nrPDB Length = 310 Score = 190 bits (483), Expect = 6e-49, Method: Composition-based stats. Identities = 62/335 (18%), Positives = 122/335 (36%), Gaps = 87/335 (25%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK----PVKKKKIKREIKILTDLSN 91 + + K+G+G + EVF+G+ ++ + IK++ + + I++EI +L+ + Sbjct: 27 PEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS 86 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 V + KD ++ Sbjct: 87 PYVTKYYGSYLKDT-----------------------------------------KLWII 105 Query: 152 FEYVDNVDFRILY--PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 EY+ L L + +I + E+LK LDY HS +HRD+K NV++ ++ + Sbjct: 106 MEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLS-EHGE 164 Query: 210 LRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 268 ++L D+G+A + ++ N V + F+ PE++ YD D+WS G + Sbjct: 165 VKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQ-SAYDSKADIWSLGITAIELARGE 223 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 P E + +K +P+ N Sbjct: 224 PP---------------------HSELHPMKVLFLIPKN----------------NPPTL 246 Query: 329 HLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + + + + ++ L + R TAKE + H + Sbjct: 247 EGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFI 281 >2XIK-A nrPDB Length = 294 Score = 190 bits (483), Expect = 8e-49, Method: Composition-based stats. Identities = 58/343 (16%), Positives = 121/343 (35%), Gaps = 87/343 (25%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK----PVKKKKIKREIKILTDLSN 91 + + +++G+G + EV++G+ +K + IK++ + + I++EI +L+ + Sbjct: 17 PEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS 76 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 I F ++ Sbjct: 77 ---------------------------------------PYITRYFGSYLKSTK--LWII 95 Query: 152 FEYVDNVDFRILYP--KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 EY+ L L + I + E+LK LDY HS +HRD+K NV++ + Sbjct: 96 MEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQG-D 154 Query: 210 LRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 268 ++L D+G+A + ++ N V + F+ PE++ YD+ D+WS G + Sbjct: 155 VKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQ-SAYDFKADIWSLGITAIELAKGE 213 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 P + + + ++ +P+ + Sbjct: 214 PP---------------------NSDLHPMRVLFLIPKN----------------SPPTL 236 Query: 329 HLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIE 371 + + ++ L D + R TAKE + H + ++ Sbjct: 237 EGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKKTS 279 >4FZF-B nrPDB Length = 283 Score = 190 bits (482), Expect = 8e-49, Method: Composition-based stats. Identities = 59/338 (17%), Positives = 116/338 (34%), Gaps = 87/338 (25%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK----PVKKKKIKREIKILTD 88 + + + ++G+G + EVF+G+ ++ + IK++ + + I++EI +L+ Sbjct: 3 MADPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQ 62 Query: 89 LSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTP 148 + V + K Sbjct: 63 CDSSYVTKYYGSYLK-----------------------------------------GSKL 81 Query: 149 ALVFEYVDNVDFRILY--PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK 206 ++ EY+ L + +I + E+LK LDY HS +HRD+K NV++ + Sbjct: 82 WIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQ 141 Query: 207 NKKLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 ++L +G+A + ++ N V + F+ PE++ YD D+WS G + Sbjct: 142 G-DVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQ-SAYDSKADIWSLGITAIELA 199 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 P + + + ++ +P+ N Sbjct: 200 KGEPP---------------------NSDMHPMRVLFLIPKN----------------NP 222 Query: 326 GNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + ID L D R TAKE + H + Sbjct: 223 PTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFI 260 >4J52-A nrPDB Length = 293 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 58/330 (17%), Positives = 122/330 (36%), Gaps = 91/330 (27%) Query: 46 VGRGKYSEVFQGVKLDSKVKIVIKM------LKPVKKKKIKREIKILTDLSNEKVPPTTL 99 +G+G +++ F+ D+K K+ LKP +++K+ EI I L Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSL---------- 71 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVD 159 H +++ +D + +V E Sbjct: 72 -----------------------------AHQHVVGFHGFFED--NDFVFVVLELCRRRS 100 Query: 160 FRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWG 216 L+ + LT+ E R+Y+ +++ Y H ++HRD+K N+ ++ ++ ++++ D+G Sbjct: 101 LLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLN-EDLEVKIGDFG 159 Query: 217 LAEFYHVNMEY-NVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGT 275 LA + E V + + PE+L + + + +D+WS G ++ +++ + PF Sbjct: 160 LATKVEYDGERKKVLCGTPNYIAPEVL-SKKGHSFEVDVWSIGCIMYTLLVGKPPF---- 214 Query: 276 SNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDE 335 + + + K E ++P+ N Sbjct: 215 ----------ETSCLKETYLRIKKNEYSIPKHI------------------------NPV 240 Query: 336 IIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 LI +L+ D R T E + +F Sbjct: 241 AASLIQKMLQTDPTARPTINELLNDEFFTS 270 >6ED6-A nrPDB Length = 415 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 74/350 (21%), Positives = 125/350 (35%), Gaps = 75/350 (21%) Query: 22 EYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKR 81 Y + +DY++ +GRG + EV S+ +K+L K + IKR Sbjct: 72 RYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLS--KFEMIKR 129 Query: 82 EIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIK 141 D + ++ D++ F ++ LF + Sbjct: 130 ---------------------SDSAFFWEERDIMAFANS----------PWVVQLFYAFQ 158 Query: 142 DPISKTPALVFEYVDNVDFRILYPKL--TDLEIRFYMFELLKALDYCHSMGIMHRDVKPH 199 D + +V EY+ D L + +FY E++ ALD HSMG++HRDVKP Sbjct: 159 D--DRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPD 216 Query: 200 NVMIDHKNKKLRLIDWGLAEFYHVNM--EYNVRVASRFFKGPELLVDYRM---YDYSLDL 254 N+++D K+ L+L D+G + V + + PE+L Y D Sbjct: 217 NMLLD-KHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDW 275 Query: 255 WSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQY 314 WS G L M+ PF+ + ++GT K + E ++ ++ Sbjct: 276 WSVGVFLYEMLVGDTPFYADS-----------LVGTYS--KIMDHKNSLCFPEDAEISKH 322 Query: 315 IRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + F+ D L R +E HP+F Sbjct: 323 AKNLICAFLTDREVRLG-------------------RNGVEEIRQHPFFK 353 >3TKU-A nrPDB Length = 433 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 70/357 (19%), Positives = 126/357 (35%), Gaps = 83/357 (23%) Query: 26 YENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKI 85 + V + + +D+EI +GRG + EV +++ +K+L K + +KR Sbjct: 78 FTQLVKEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILN--KWEMLKRAETA 135 Query: 86 LTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPIS 145 + + + +Y Q E+ Sbjct: 136 CFREERDVLVNGDCQWITALHYAFQDEN-------------------------------- 163 Query: 146 KTPALVFEYVDNVDFRILYPK----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNV 201 LV +Y D L K L + RFY+ E++ A+D H + +HRD+KP NV Sbjct: 164 -HLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNV 222 Query: 202 MIDHKNKKLRLIDWGLAEFYHVNM--EYNVRVASRFFKGPELLV----DYRMYDYSLDLW 255 ++D N +RL D+G + + + +V V + + PE+L Y D W Sbjct: 223 LLDV-NGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWW 281 Query: 256 SFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYI 315 S G + M++ PF+ S + KI+ F ++ Sbjct: 282 SLGVCMYEMLYGETPFY-AESLVETYGKIMNHEERFQFPSHV------------------ 322 Query: 316 RKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERL---TAKEAMGHPWFAPIREQ 369 ++E DLI L+ + RL ++ H +F + + Sbjct: 323 --------------TDVSEEAKDLIQRLI-CSRERRLGQNGIEDFKKHAFFEGLNWE 364 >2H8H-A nrPDB Length = 535 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 63/365 (17%), Positives = 126/365 (34%), Gaps = 95/365 (26%) Query: 20 TEEYWDYENTVID-WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--VKK 76 + D W + +E K+G+G + EV+ G + ++ IK LKP + Sbjct: 248 PTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSP 306 Query: 77 KKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHL 136 + +E +++ L +EK+ + L Sbjct: 307 EAFLQEAQVMKKLRHEKL---------------------------------------VQL 327 Query: 137 FDIIKDPISKTPALVFEYVDNVDFRILY-----PKLTDLEIRFYMFELLKALDYCHSMGI 191 + ++ + + +V EY+ L ++ ++ + Y M Sbjct: 328 YAVVSE---EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 384 Query: 192 MHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMY 248 +HRD++ N+++ +N ++ D+GLA N EY R ++F + PE + Y + Sbjct: 385 VHRDLRAANILVG-ENLVCKVADFGLARLIEDN-EYTARQGAKFPIKWTAPEAAL-YGRF 441 Query: 249 DYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREF 308 D+WSFG +L + K + G N + L ++ + Y + P Sbjct: 442 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER--------GYRMPCPPECPESL 493 Query: 309 YDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAK--EAMGHPWFAPI 366 + DL+ R + +ER T + +A +F Sbjct: 494 H----------------------------DLMCQCWRKEPEERPTFEYLQAFLEDYFTST 525 Query: 367 REQIE 371 Q + Sbjct: 526 EPQYQ 530 >4U41-A nrPDB Length = 332 Score = 189 bits (480), Expect = 1e-48, Method: Composition-based stats. Identities = 60/346 (17%), Positives = 118/346 (34%), Gaps = 91/346 (26%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPV--KKKKIKREIKILTDLSNEKVPPT 97 +E+ VG G Y +V++G + + IK++ ++++IK EI +L S+ Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSH------ 79 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI----SKTPALVFE 153 H NI + LV E Sbjct: 80 --------------------------------HRNIATYYGAFIKKSPPGHDDQLWLVME 107 Query: 154 YVDNVDFRILYP-----KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK 208 + L L + I + E+L+ L + H ++HRD+K NV++ +N Sbjct: 108 FCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLT-ENA 166 Query: 209 KLRLIDWGL-AEFYHVNMEYNVRVASRFFKGPELLVDYR----MYDYSLDLWSFGTMLAS 263 +++L+D+G+ A+ N + + ++ PE++ YDY DLWS G Sbjct: 167 EVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIE 226 Query: 264 MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFI 323 M P + + ++ +PR Sbjct: 227 MAEGAPPL---------------------CDMHPMRALFLIPRN---------------P 250 Query: 324 NDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 K + + I+ L ++ +R + ++ + HP+ + Sbjct: 251 PPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNE 296 >5J5T-A nrPDB Length = 370 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 58/339 (17%), Positives = 125/339 (36%), Gaps = 84/339 (24%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKI---KREIKILTDLSNE 92 + +D+E+ ++G G Y +V++ +++ IK++K + ++EI ++ D Sbjct: 2 SQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCK-- 59 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF 152 H NI+ F + Sbjct: 60 -------------------------------------HPNIVAYFGSYLR--RDKLWICM 80 Query: 153 EYVDNVDFRILY---PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 E+ + +Y L++L+I + E L+ L Y HS G MHRD+K N+++ N Sbjct: 81 EFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLT-DNGH 139 Query: 210 LRLIDWGLAEFYHVN-MEYNVRVASRFFKGPEL--LVDYRMYDYSLDLWSFGTMLASMIF 266 ++L D+G++ + + + ++ PE+ + Y+ DLW+ G + Sbjct: 140 VKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAE 199 Query: 267 KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG 326 + P F ++ + ++ S+F+ LK ++ F+ Sbjct: 200 LQPPMFDLHP-----MRALFLMTKSNFQPPKLKDKMKWSNSFHH---------------- 238 Query: 327 NKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 + L + ++R TA++ + HP+ Sbjct: 239 ------------FVKMALTKNPKKRPTAEKLLQHPFVTQ 265 >6GQK-A nrPDB Length = 328 Score = 189 bits (480), Expect = 2e-48, Method: Composition-based stats. Identities = 62/372 (16%), Positives = 122/372 (32%), Gaps = 113/372 (30%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQG-----VKLDSKVKIVIKMLKP----VKKKKIKRE 82 W +G G + +V + +K D+ + + +KMLKP +++ + E Sbjct: 35 KWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSE 94 Query: 83 IKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD 142 +K+L+ L N H NI++L Sbjct: 95 LKVLSYLGN--------------------------------------HENIVNLLGACTH 116 Query: 143 PISKTPALVFEYVDNVDFRILYPK-------------------LTDLEIRFYMFELLKAL 183 ++ EY D + LT + + +++ K + Sbjct: 117 --GGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGM 174 Query: 184 DYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPE 240 + S +HRD+ N+++ H N ++ D+GLA + Y + +R + PE Sbjct: 175 AFLASKNCIHRDLAARNILLTHGNIT-KICDFGLARDIKNDSNYVDKGNARLPVKWMAPE 233 Query: 241 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 300 + + +Y + D+WS+G L + + G + K++K E + + Sbjct: 234 SIFN-SVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIK-------EGFRMSS 285 Query: 301 EITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGH 360 P E Y D++ D +R T K+ + Sbjct: 286 PEYAPAEMY----------------------------DIMKTCWDADPDKRPTFKQIVQ- 316 Query: 361 PWFAPIREQIEK 372 I +QI + Sbjct: 317 ----DIEKQISE 324 >2VWV-A nrPDB Length = 302 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 65/355 (18%), Positives = 130/355 (36%), Gaps = 73/355 (20%) Query: 25 DYENTVIDW--STNTKDYEIENKVGRGKYSEVFQGVKLDSKVK---IVIKMLKPVKKKKI 79 D V ++ + +IE +G G++ EV +G K + IK LK ++ Sbjct: 1 DPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQ 60 Query: 80 KREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDI 139 +RE H NII L + Sbjct: 61 RRE-----------------------------------FLSEASIMGQFEHPNIIRLEGV 85 Query: 140 IKDPISKTPALVFEYVDNVDF----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRD 195 + + + ++ E+++N R+ + T +++ + + + Y M +HRD Sbjct: 86 VTNSM--PVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRD 143 Query: 196 VKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF------FKGPELLVDYRMYD 249 + N++++ N ++ D+GL+ F N +S + PE + +R + Sbjct: 144 LAARNILVNS-NLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWTAPEAIA-FRKFT 201 Query: 250 YSLDLWSFGTMLAS-MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREF 308 + D WS+G ++ M F P++ SN D + I + Y L P Sbjct: 202 SASDAWSYGIVMWEVMSFGERPYWD-MSNQDVINAI--------EQDYRLPPPPDCP--- 249 Query: 309 YDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMG--HP 361 + Q + W + N + +++ +D ++R ++ A+E G HP Sbjct: 250 TSLHQLMLDCWQKDRNARPRF----PQVVSALDKMIRNPASLKIVARENGGASHP 300 >1TKI-A nrPDB Length = 321 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 68/341 (19%), Positives = 130/341 (38%), Gaps = 83/341 (24%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIK--MLKPVKKKKIKREIKILTDLSNEKVP 95 + Y I +GRG++ V + V+ SK + K +K + +K+EI IL Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISILN-------- 56 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 H NI+HL + + ++FE++ Sbjct: 57 -------------------------------IARHRNILHLHESFESMEE--LVMIFEFI 83 Query: 156 DNVDFRILYP----KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI-DHKNKKL 210 +D +L + EI Y+ ++ +AL + HS I H D++P N++ ++ + Sbjct: 84 SGLDIFERINTSAFELNEREIVSYVHQVCEALQFLHSHNIGHFDIRPENIIYQTRRSSTI 143 Query: 211 RLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 ++I++G A + + + + PE+ + + + D+WS GT++ ++ P Sbjct: 144 KIIEFGQARQLKPGDNFRLLFTAPEYYAPEVHQ-HDVVSTATDMWSLGTLVYVLLSGINP 202 Query: 271 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 330 F +N + I+ T D E Sbjct: 203 FL-AETNQQIIENIMNAEYTFDEE---------------------------------AFK 228 Query: 331 SGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIE 371 + E +D +D LL + + R+TA EA+ HPW E++ Sbjct: 229 EISIEAMDFVDRLLVKERKSRMTASEALQHPWLKQKIERVS 269 >6F3F-A nrPDB Length = 455 Score = 189 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 63/365 (17%), Positives = 127/365 (34%), Gaps = 95/365 (26%) Query: 20 TEEYWDYENTVID-WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--VKK 76 + D W + +E K+G+G + EV+ G + ++ IK LKP + Sbjct: 168 PTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSP 226 Query: 77 KKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHL 136 + +E +++ L +EK+ + L Sbjct: 227 EAFLQEAQVMKKLRHEKL---------------------------------------VQL 247 Query: 137 FDIIKDPISKTPALVFEYVDNVDFRILY-----PKLTDLEIRFYMFELLKALDYCHSMGI 191 + ++ + + +V EY++ L ++ ++ + Y M Sbjct: 248 YAVVSE---EPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNY 304 Query: 192 MHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMY 248 +HRD++ N+++ +N ++ D+GLA N EY R ++F + PE + Y + Sbjct: 305 VHRDLRAANILVG-ENLVCKVADFGLARLIEDN-EYTARQGAKFPIKWTAPEAAL-YGRF 361 Query: 249 DYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREF 308 D+WSFG +L + K + G N + L ++ + Y + P Sbjct: 362 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER--------GYRMPCPPECPESL 413 Query: 309 YDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAK--EAMGHPWFAPI 366 + DL+ R + +ER T + +A +F Sbjct: 414 H----------------------------DLMCQCWRKEPEERPTFEYLQAFLEDYFTST 445 Query: 367 REQIE 371 Q + Sbjct: 446 EPQYQ 450 >6HXF-B nrPDB Length = 302 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 61/343 (17%), Positives = 123/343 (35%), Gaps = 89/343 (25%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIK---REIKILTDLSNE 92 + +EI ++G G + +V++ ++ K+++ +++++ EI+IL Sbjct: 17 PNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCD-- 74 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF 152 H I+ L ++ Sbjct: 75 -------------------------------------HPYIVKLLGAYYH--DGKLWIMI 95 Query: 153 EYVDNVD----FRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK 208 E+ L LT+ +I+ ++L+AL++ HS I+HRD+K NV++ + Sbjct: 96 EFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEG- 154 Query: 209 KLRLIDWGL-AEFYHVNMEYNVRVASRFFKGPELL----VDYRMYDYSLDLWSFGTMLAS 263 +RL D+G+ A+ + + + + ++ PE++ + YDY D+WS G L Sbjct: 155 DIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIE 214 Query: 264 MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFI 323 M + EP H + L+KI K Sbjct: 215 MA-QIEPPHHELNPMRVLLKIAK----------------------------------SDP 239 Query: 324 NDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPI 366 + E D + L + + R +A + + HP+ + I Sbjct: 240 PTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSI 282 >4B6L-A nrPDB Length = 281 Score = 188 bits (477), Expect = 3e-48, Method: Composition-based stats. Identities = 59/339 (17%), Positives = 126/339 (37%), Gaps = 91/339 (26%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML------KPVKKKKIKREIKILTDL 89 + + Y +G+G ++ ++ ++ +K++ KP +++KI EI++ DL Sbjct: 7 SGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDL 66 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 H +I+ +D + Sbjct: 67 Q---------------------------------------HRHIVRFSHHFEDADN--IY 85 Query: 150 LVFEYVDNVDFRILYP---KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK 206 + E ++ L + E+R+Y+ ++L L Y H GI+HRD+K N I + Sbjct: 86 IFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFIT-E 144 Query: 207 NKKLRLIDWGLAEFYHVNMEY-NVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 N +L++ D+GLA + + + PE+L+ + + D+WS G ++ +++ Sbjct: 145 NMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLL-RQGHGPEADVWSLGCVMYTLL 203 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 PF T++ + + +K + Y L ++LP Sbjct: 204 CGSPPF--ETADLKETYRCIKQV------HYTLPASLSLP-------------------- 235 Query: 326 GNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 L+ +LR ++R + + + H +F Sbjct: 236 ----------ARQLLAAILRASPRDRPSIDQILRHDFFT 264 >3A4O-X nrPDB Length = 286 Score = 188 bits (477), Expect = 3e-48, Method: Composition-based stats. Identities = 60/312 (19%), Positives = 124/312 (39%), Gaps = 56/312 (17%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--VKKKKIKREIKILTDLS 90 W + ++ ++G G++ EV+ G ++ K+ +K LKP + + E ++ L Sbjct: 8 WEIPRESIKLVKRLGAGQFGEVWMGYY-NNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQ 66 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 ++K+ Y +E+ + I Y+ L D +K Sbjct: 67 HDKLVRL--------YAVVTREEPIYIITEYMAKGS---------LLDFLKSDEGG---- 105 Query: 151 VFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 ++L PKL D + ++ + + Y +HRD++ NV++ ++ Sbjct: 106 ----------KVLLPKLID-----FSAQIAEGMAYIERKNYIHRDLRAANVLVS-ESLMC 149 Query: 211 RLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 ++ D+GLA N EY R ++F + PE + ++ + D+WSFG +L ++ Sbjct: 150 KIADFGLARVIEDN-EYTAREGAKFPIKWTAPEAI-NFGCFTIKSDVWSFGILLYEIVTY 207 Query: 268 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGN 327 + + G +N D + T+ + Y + P E YD+ ++ W + Sbjct: 208 GKIPYPGRTNADVM--------TALSQGYRMPRVENCPDELYDI---MKMCWKEKAEERP 256 Query: 328 KHLSGNDEIIDL 339 + D Sbjct: 257 TFDYLQSVLDDF 268 >4C0T-A nrPDB Length = 974 Score = 188 bits (477), Expect = 3e-48, Method: Composition-based stats. Identities = 67/345 (19%), Positives = 124/345 (35%), Gaps = 87/345 (25%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVP 95 N D++ ++G G YS V + + +K+L K+ I +E K+ Sbjct: 264 NVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVL---DKRHIIKEKKV---------- 310 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 +++ N+ + L +I L+ +D + V +Y Sbjct: 311 ---KYVNIEKHALNRLSNRLG----------------VISLYFTFQD--KDSLYFVLDYA 349 Query: 156 DNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRL 212 N + L + L + R + ++L A+ Y H G++HRD+KP N+++D K ++++ Sbjct: 350 SNGELLTLIKRYNTLNEECTRHFGAQILDAIKYMHDNGVIHRDLKPENILLDDK-MRIQI 408 Query: 213 IDWGLAEFYH----------VNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLA 262 D+G A V++ V + + PELL + + D+W+FG ++ Sbjct: 409 TDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPELLEN-KYCGKPGDVWAFGCIIY 467 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 MI + PF K + + K + F + Sbjct: 468 QMIAGKPPF--------------KATNEYLTFQKITKLQFAFSAGFPTI----------- 502 Query: 323 INDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIR 367 I DLI +L R T E H +F + Sbjct: 503 -------------IRDLIKKILVLQPSRRATIPEIQKHYFFQSVD 534 >2PL0-A nrPDB Length = 289 Score = 188 bits (476), Expect = 4e-48, Method: Composition-based stats. Identities = 55/337 (16%), Positives = 126/337 (37%), Gaps = 71/337 (21%) Query: 13 TNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK 72 +++ Q+ ++ W +E+ +W + ++ ++G G++ EV+ G + K+ +K LK Sbjct: 2 SHMQTQKPQKPW-WED---EWEVPRETLKLVERLGAGQFGEVWMGYY-NGHTKVAVKSLK 56 Query: 73 --PVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGH 130 + E ++ L ++++ Sbjct: 57 QGSMSPDAFLAEANLMKQLQHQRL------------------------------------ 80 Query: 131 ANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYP-----KLTDLEIRFYMFELLKALDY 185 + L+ ++ + ++ EY++N KLT ++ ++ + + + Sbjct: 81 ---VRLYAVVTQ---EPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAF 134 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELL 242 +HRD++ N+++ ++ D+GLA N EY R ++F + PE + Sbjct: 135 IEERNYIHRDLRAANILVS-DTLSCKIADFGLARLIEDN-EYTAREGAKFPIKWTAPEAI 192 Query: 243 VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEI 302 +Y + D+WSFG +L ++ + G +N + + + + Y + Sbjct: 193 -NYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLER--------GYRMVRPD 243 Query: 303 TLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDL 339 P E Y Q +R W D + D Sbjct: 244 NCPEELY---QLMRLCWKERPEDRPTFDYLRSVLEDF 277 >2Y6O-A nrPDB Length = 291 Score = 188 bits (476), Expect = 5e-48, Method: Composition-based stats. Identities = 65/339 (19%), Positives = 126/339 (37%), Gaps = 75/339 (22%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVK---IVIKMLKP----VKKKKIKREIKIL 86 + +IE +G G++ EV G + + IK LK +++ E I+ Sbjct: 10 EIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIM 69 Query: 87 TDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISK 146 H NIIHL ++ K Sbjct: 70 GQ---------------------------------------FDHPNIIHLEGVVTK--CK 88 Query: 147 TPALVFEYVDNVDF----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM 202 ++ EY++N R + T +++ + + + Y M +HRD+ N++ Sbjct: 89 PVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNIL 148 Query: 203 IDHKNKKLRLIDWGLAEFYHVNME--YNVRVASRF--FKGPELLVDYRMYDYSLDLWSFG 258 ++ N ++ D+G++ + E Y R + PE + YR + + D+WS+G Sbjct: 149 VNS-NLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIA-YRKFTSASDVWSYG 206 Query: 259 TMLAS-MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRK 317 ++ M + P++ SN D + I E Y L + P + Q + Sbjct: 207 IVMWEVMSYGERPYWD-MSNQDVIKAI--------EEGYRLPPPMDCP---IALHQLMLD 254 Query: 318 PWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKE 356 W + +D K +I++++D L+R + + T E Sbjct: 255 CWQKERSDRPKF----GQIVNMLDKLIRNPNSLKRTGSE 289 >5HI2-A nrPDB Length = 283 Score = 188 bits (476), Expect = 5e-48, Method: Composition-based stats. Identities = 56/332 (16%), Positives = 123/332 (37%), Gaps = 62/332 (18%) Query: 21 EEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIK 80 + ++ DW + ++G G + V++G + +KML P + + K Sbjct: 3 HHHHGSRDSSDDWEIPDGQITVGQRIGSGSFGTVYKG---KWHGDVAVKMLTPQQLQAFK 59 Query: 81 REIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII 140 E+ +L H NI+ Sbjct: 60 NEVGVLRK---------------------------------------TRHVNILLFMGYS 80 Query: 141 KDPISKTPALVFEYVDNVDFRILYP----KLTDLEIRFYMFELLKALDYCHSMGIMHRDV 196 P A+V ++ + K ++ + + +DY H+ I+HRD+ Sbjct: 81 TKPQ---LAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDL 137 Query: 197 KPHNVMIDHKNKKLRLIDWGLAEF---YHVNMEYNVRVASRFFKGPELL--VDYRMYDYS 251 K +N+ + H++ +++ D+GLA + + ++ S + PE++ D Y + Sbjct: 138 KSNNIFL-HEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDSNPYSFQ 196 Query: 252 LDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDM 311 D+++FG +L ++ + P+ SN + +I++++G L K P+ M Sbjct: 197 SDVYAFGIVLYELMTGQLPY----SNINNRDQIIEMVGRGSLSPDLSKVRSNCPKR---M 249 Query: 312 DQYIRKPWHRFINDGNKHLSGNDEIIDLIDNL 343 + + + + ++ EI +L L Sbjct: 250 KRLMAECLKKKRDERPSFPRILAEIEELAREL 281 >4AW2-A nrPDB Length = 437 Score = 188 bits (476), Expect = 5e-48, Method: Composition-based stats. Identities = 72/357 (20%), Positives = 128/357 (35%), Gaps = 85/357 (23%) Query: 26 YENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKI 85 + + V + +D+EI +GRG + EV ++ +K+L K + +KR Sbjct: 62 FTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILN--KWEMLKRAETA 119 Query: 86 LTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPIS 145 + + + +Y Q ++ L Sbjct: 120 CFREERDVLVNGDSKWITTLHYAFQDDNNL------------------------------ 149 Query: 146 KTPALVFEYVDNVDFRILYP----KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNV 201 LV +Y D L +L + RFY+ E++ A+D H + +HRD+KP N+ Sbjct: 150 ---YLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNI 206 Query: 202 MIDHKNKKLRLIDWGLAEFYHVNM--EYNVRVASRFFKGPELLV----DYRMYDYSLDLW 255 ++D N +RL D+G + + +V V + + PE+L Y D W Sbjct: 207 LMD-MNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEGGKGRYGPECDWW 265 Query: 256 SFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYI 315 S G + M++ PF+ S + KI+ K P + D+ Sbjct: 266 SLGVCMYEMLYGETPFY-AESLVETYGKIMN-----------HKERFQFPTQVTDV---- 309 Query: 316 RKPWHRFINDGNKHLSGNDEIIDLIDNLL-RYDHQERL---TAKEAMGHPWFAPIRE 368 ++ DLI L+ +H RL ++ HP+F+ I Sbjct: 310 -----------------SENAKDLIRRLICSREH--RLGQNGIEDFKKHPFFSGIDW 347 >5MJB-A nrPDB Length = 305 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 62/345 (17%), Positives = 127/345 (36%), Gaps = 80/345 (23%) Query: 25 DYENTVIDW--STNTKDYEIENKVGRGKYSEVFQGVKLDSKVK---IVIKMLKPVKKKK- 78 D V ++ + +IE +G G++ EV++G + + IK LK +K Sbjct: 11 DPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQ 70 Query: 79 ---IKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIH 135 E I+ H NII Sbjct: 71 RRDFLSEASIMGQ---------------------------------------FDHRNIIR 91 Query: 136 LFDIIKDPISKTPALVFEYVDNVDF----RILYPKLTDLEIRFYMFELLKALDYCHSMGI 191 L ++ S+ ++ E+++N R + T +++ + + + Y M Sbjct: 92 LEGVVTK--SRPVMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNY 149 Query: 192 MHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHV---NMEYNVRVASRF---FKGPELLVDY 245 +HRD+ N++++ N ++ D+GL+ + + Y + + + PE + Y Sbjct: 150 VHRDLAARNILVNS-NLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIA-Y 207 Query: 246 RMYDYSLDLWSFGTMLAS-MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 R + + D+WS+G ++ M F P++ SN D + I + Y L + Sbjct: 208 RKFTSASDVWSYGIVMWEVMSFGERPYWD-MSNQDVINAI--------EQDYRLPPPMDC 258 Query: 305 PREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQ 349 P + Q + W + N + EI++ +D ++R + Sbjct: 259 PAALH---QLMLDCWQKDRNSRPRF----AEIVNTLDKMIR-NPA 295 >2XYN-A nrPDB Length = 292 Score = 187 bits (474), Expect = 9e-48, Method: Composition-based stats. Identities = 51/314 (16%), Positives = 112/314 (35%), Gaps = 65/314 (20%) Query: 26 YENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--VKKKKIKREI 83 Y ++ W D +++K+G G+Y EV+ GV + + +K LK ++ ++ +E Sbjct: 20 YFQSMDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEA 79 Query: 84 KILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP 143 ++ ++ H N++ L + Sbjct: 80 AVMKEIK---------------------------------------HPNLVQLLGVCT-- 98 Query: 144 ISKTPALVFEYVDNVDFRILYPKLTDLEI-----RFYMFELLKALDYCHSMGIMHRDVKP 198 + +V EY+ + + E+ + ++ A++Y +HRD+ Sbjct: 99 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 158 Query: 199 HNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLW 255 N ++ +N +++ D+GL+ Y ++F + PE L Y + D+W Sbjct: 159 RNCLVG-ENHVVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLA-YNTFSIKSDVW 215 Query: 256 SFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYI 315 +FG +L + + G + + K Y ++ P + Y++ + Sbjct: 216 AFGVLLWEIATYGMSPYPGIDLSQVYDLLEK--------GYRMEQPEGCPPKVYEL---M 264 Query: 316 RKPWHRFINDGNKH 329 R W D Sbjct: 265 RACWKWSPADRPSF 278 >1JPA-A nrPDB Length = 312 Score = 186 bits (473), Expect = 9e-48, Method: Composition-based stats. Identities = 60/351 (17%), Positives = 125/351 (35%), Gaps = 80/351 (22%) Query: 19 RTEEYWDYENTVIDW--STNTKDYEIENKVGRGKYSEVFQGVKLDSKVK---IVIKMLKP 73 + D V ++ + +IE +G G++ EV G + + IK LK Sbjct: 12 DPFTFEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKS 71 Query: 74 VKKKK----IKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNG 129 +K E I+ Sbjct: 72 GYTEKQRRDFLSEASIMGQ---------------------------------------FD 92 Query: 130 HANIIHLFDIIKDPISKTPALVFEYVDNVDF----RILYPKLTDLEIRFYMFELLKALDY 185 H N+IHL ++ ++ E+++N R + T +++ + + + Y Sbjct: 93 HPNVIHLEGVVTKST--PVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKY 150 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHV---NMEYNVRVASRF---FKGP 239 M +HRD+ N++++ N ++ D+GL+ F + Y + + + P Sbjct: 151 LADMNYVHRDLAARNILVNS-NLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAP 209 Query: 240 ELLVDYRMYDYSLDLWSFGTMLAS-MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLL 298 E + YR + + D+WS+G ++ M + P++ +N D + I + Y L Sbjct: 210 EAIQ-YRKFTSASDVWSYGIVMWEVMSYGERPYWD-MTNQDVINAI--------EQDYRL 259 Query: 299 KYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQ 349 + P + Q + W + N K +I++ +D ++R + Sbjct: 260 PPPMDCPSALH---QLMLDCWQKDRNHRPKF----GQIVNTLDKMIR-NPN 302 >5X02-A nrPDB Length = 347 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 63/354 (17%), Positives = 127/354 (35%), Gaps = 81/354 (22%) Query: 22 EYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGV-----KLDSKVKIVIKMLKPV-- 74 ++ +YE + W ++ E +G G + +V K +++ +KMLK Sbjct: 33 DFREYEYD-LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKAD 91 Query: 75 --KKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHAN 132 +++ + E+K++T L H N Sbjct: 92 SSEREALMSELKMMTQL--------------------------------------GSHEN 113 Query: 133 IIHLFDIIKDPISKTPALVFEYVDNVD----FRILYPKLTDLEIRF-------------- 174 I++L +S L+FEY D R K ++ EI + Sbjct: 114 IVNLLGACT--LSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNV 171 Query: 175 --------YMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME 226 + +++ K +++ +HRD+ NV++ H K +++ D+GLA + Sbjct: 172 LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH-GKVVKICDFGLARDIMSDSN 230 Query: 227 YNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVK 283 Y VR +R + PE L + +Y D+WS+G +L + + G K Sbjct: 231 YVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYK 289 Query: 284 IVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEII 337 +++ D Y + + + + D R + + L+ +E + Sbjct: 290 LIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAM 343 >4PDO-A nrPDB Length = 299 Score = 186 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 65/347 (18%), Positives = 126/347 (36%), Gaps = 78/347 (22%) Query: 18 QRTEEYWDYENTVIDW--STNTKDYEIENKVGRGKYSEVFQGVKL----DSKVKIVIKML 71 Q Y D V+ + + + +G G++ EV++G+ +V + IK L Sbjct: 12 QDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTL 71 Query: 72 KPVKKKK----IKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPH 127 K +K E I+ Sbjct: 72 KAGYTEKQRVDFLGEAGIMGQ--------------------------------------- 92 Query: 128 NGHANIIHLFDIIKDPISKTPALVFEYVDNVDF----RILYPKLTDLEIRFYMFELLKAL 183 H NII L +I K ++ EY++N R + + L++ + + + Sbjct: 93 FSHHNIIRLEGVISK--YKPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGM 150 Query: 184 DYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME--YNVRVASRF--FKGP 239 Y +M +HRD+ N++++ N ++ D+GL+ + E Y + P Sbjct: 151 KYLANMNYVHRDLAARNILVNS-NLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAP 209 Query: 240 ELLVDYRMYDYSLDLWSFGTMLAS-MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLL 298 E + YR + + D+WSFG ++ M + P++ SN + + I + + L Sbjct: 210 EAI-SYRKFTSASDVWSFGIVMWEVMTYGERPYW-ELSNHEVMKAI--------NDGFRL 259 Query: 299 KYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLR 345 + P Y Q + + W + K +I+ ++D L+R Sbjct: 260 PTPMDCPSAIY---QLMMQCWQQERARRPKF----ADIVSILDKLIR 299 >4CRL-A nrPDB Length = 406 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 71/372 (19%), Positives = 149/372 (40%), Gaps = 71/372 (19%) Query: 24 WDYENTVIDWSTNTKD-YEIEN-KVGRGKYSEVFQGVKLDSKVK--IVIKMLKPVKKKK- 78 +D++ + +D +E E KVGRG Y V++ + D K +K ++ Sbjct: 6 YDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMS 65 Query: 79 IKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFD 138 REI +L +L H N+I L Sbjct: 66 ACREIALLRELK---------------------------------------HPNVISLQK 86 Query: 139 IIKDPISKTPALVFEYVDNVDFRILY-----------PKLTDLEIRFYMFELLKALDYCH 187 + + L+F+Y ++ + I+ +L ++ ++++L + Y H Sbjct: 87 VFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLH 146 Query: 188 SMGIMHRDVKPHNVMI---DHKNKKLRLIDWGLAEFYHVNME----YNVRVASRFFKGPE 240 + ++HRD+KP N+++ + ++++ D G A ++ ++ + V + +++ PE Sbjct: 147 ANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPE 206 Query: 241 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNT--------DQLVKIVKVLGTSD 292 LL+ R Y ++D+W+ G + A ++ F + DQL +I V+G Sbjct: 207 LLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPA 266 Query: 293 FEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH-LSGNDEIIDLIDNLLRYDHQER 351 + + ++ + I KH + + + L+ LL D +R Sbjct: 267 DKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKR 326 Query: 352 LTAKEAMGHPWF 363 +T+++AM P+F Sbjct: 327 ITSEQAMQDPYF 338 >4OLI-A nrPDB Length = 645 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 71/386 (18%), Positives = 140/386 (36%), Gaps = 85/386 (22%) Query: 6 WSEARVYTNINKQRTEEYWD-----YENTVIDWSTNTKDY-EIENKVGRGKYSEV----F 55 S + ++ + + D ++ D + K Y + +G G + +V + Sbjct: 315 PSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCY 374 Query: 56 QGVKLDSKVKIVIKMLK----PVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQK 111 + + +K LK P + K+EI IL L Sbjct: 375 DPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTL---------------------- 412 Query: 112 EDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLT--D 169 H +II +D K+ LV EYV R P+ + Sbjct: 413 -----------------YHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGL 455 Query: 170 LEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNV 229 ++ + ++ + + Y HS +HR++ NV++D+ ++ +++ D+GLA+ EY Sbjct: 456 AQLLLFAQQICEGMAYLHSQHYIHRNLAARNVLLDN-DRLVKIGDFGLAKAVPEGHEYYR 514 Query: 230 RV----ASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIV 285 + F+ PE L +Y+ Y Y+ D+WSFG L ++ H S+ K + Sbjct: 515 VREDGDSPVFWYAPECLKEYKFY-YASDVWSFGVTLYELLT------HCDSSQSPPTKFL 567 Query: 286 KVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLR 345 +++G + + +L+ L R + E+ L+ N Sbjct: 568 ELIGIAQGQMTVLRLTELLERG----------------ERLPRPDKCPCEVYHLMKNCWE 611 Query: 346 YDHQERLTAKEAMGHPWFAPIREQIE 371 + R T + + P + E+ + Sbjct: 612 TEASFRPTFENLI--PILKTVHEKYQ 635 Score = 77.9 bits (190), Expect = 6e-15, Method: Composition-based stats. Identities = 45/337 (13%), Positives = 97/337 (28%), Gaps = 66/337 (19%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 93 + K+ + +G+G + V++G ++ K+ E ++ + Sbjct: 41 RVDQKEITQLSHLGQGTRTNVYEGRLRVEGS-------GDPEEGKMDDEDPLVPGRDRGQ 93 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 L + D+ H ++ + + +V E Sbjct: 94 ELRVVLKVLDPSH-----HDIALAFYETASLMSQVSHTHLAFVHGVCVRGPEN--IMVTE 146 Query: 154 YVDNVDF----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 YV++ R + +L AL Y + ++H +V N+++ Sbjct: 147 YVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLA 206 Query: 210 ------LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDY-RMYDYSLDLWSFGTMLA 262 ++L D G+ E R+ + PE L ++D W FG L Sbjct: 207 EGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGATLL 263 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 + F E S +++ FY + +P Sbjct: 264 EICFDGEAPLQSRSPSEK-------------------------EHFYQRQHRLPEP---- 294 Query: 323 INDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMG 359 ++ L L Y+ +R + + + Sbjct: 295 ---------SCPQLATLTSQCLTYEPTQRPSFRTILR 322 >2WO6-A nrPDB Length = 382 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 77/363 (21%), Positives = 156/363 (42%), Gaps = 63/363 (17%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPP 96 YEI++ +G+G + +V + + + IK++K KK + +I L Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKN--KKAFLNQAQIEVRLLE----- 105 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 +++ T K ++ R ++F ++ +F+++ +++ + Sbjct: 106 -----LMNKHDTEMKYYIVHLKRHFMFRN------HLCLVFEMLS-------YNLYDLLR 147 Query: 157 NVDFRILYPKLTDLEIRFYMFELLKALDYCH--SMGIMHRDVKPHNVMI-DHKNKKLRLI 213 N +FR + LT R + ++ AL + + I+H D+KP N+++ + K ++++ Sbjct: 148 NTNFRGVSLNLT----RKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIV 203 Query: 214 DWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFH 273 D+G + + SRF++ PE+L+ YD ++D+WS G +L M P F Sbjct: 204 DFGSSCQL--GQRIYQYIQSRFYRSPEVLLGM-PYDLAIDMWSLGCILVEMHTGE-PLFS 259 Query: 274 GTSNTDQLVKIVKVLGTS-----DFEKYLLKYEITLPREFYDMDQYI------RKPWHRF 322 G + DQ+ KIV+VLG D K+ LP +++ + + P R Sbjct: 260 GANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRK 319 Query: 323 INDGNKHLSGND----------------EIIDLIDNLLRYDHQERLTAKEAMGHPWFAPI 366 +++ +G + DLI +L YD + R+ A+ H +F Sbjct: 320 LHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 379 Query: 367 REQ 369 ++ Sbjct: 380 ADE 382 >3PFQ-A nrPDB Length = 674 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 55/345 (15%), Positives = 109/345 (31%), Gaps = 83/345 (24%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 93 D+ +G+G + +V + + +K+LK Sbjct: 337 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKD------------------- 377 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 Q +DV + + L V E Sbjct: 378 -------------VVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCF--QTMDRLYFVME 422 Query: 154 YVDNVDFRILYP---KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 YV+ D + + FY E+ L + S GI++RD+K NVM+D + + Sbjct: 423 YVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEG-HI 481 Query: 211 RLIDWGLAEF-YHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 ++ D+G+ + + + + PE++ Y+ Y S+D W+FG +L M+ + Sbjct: 482 KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA-YQPYGKSVDWWAFGVLLYEMLAGQA 540 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 PF G + I++ + + P+ Sbjct: 541 PF-EGEDEDELFQSIME-------------HNVAYPKSM--------------------- 565 Query: 330 LSGNDEIIDLIDNLLRYDHQERLTA-----KEAMGHPWFAPIREQ 369 + E + + L+ +RL ++ H +F I + Sbjct: 566 ---SKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWE 607 >3G0E-A nrPDB Length = 336 Score = 184 bits (467), Expect = 4e-47, Method: Composition-based stats. Identities = 60/344 (17%), Positives = 119/344 (34%), Gaps = 89/344 (25%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQG-----VKLDSKVKIVIKMLKP----VKKKKIKRE 82 W +G G + +V + +K D+ + + +KMLKP +++ + E Sbjct: 40 KWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSE 99 Query: 83 IKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD 142 +K+L+ L N H NI++L Sbjct: 100 LKVLSYLGN--------------------------------------HMNIVNLLGACT- 120 Query: 143 PISKTPALVFEYVDNVDFRILYPKLTDLEI---------------------RFYMFELLK 181 I ++ EY D + D I + +++ K Sbjct: 121 -IGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQVAK 179 Query: 182 ALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKG 238 + + S +HRD+ N+++ H + ++ D+GLA + Y V+ +R + Sbjct: 180 GMAFLASKNCIHRDLAARNILLTH-GRITKICDFGLARDIKNDSNYVVKGNARLPVKWMA 238 Query: 239 PELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLL 298 PE + + +Y + D+WS+G L + + G + K++K E + + Sbjct: 239 PESIFNC-VYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIK-------EGFRM 290 Query: 299 KYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDN 342 P E YD+ ++ W +I+ LI+ Sbjct: 291 LSPEHAPAEMYDI---MKTCWDADPLKRPTF----KQIVQLIEK 327 >2BRG-A nrPDB Length = 297 Score = 184 bits (467), Expect = 5e-47, Method: Composition-based stats. Identities = 56/336 (16%), Positives = 114/336 (33%), Gaps = 87/336 (25%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK----KKIKREIKILTDLSNEK 93 +D+++ +G G Y EV V ++ + +K++ + + IK+EI I L+ Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLN--- 63 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 H N++ + L E Sbjct: 64 ------------------------------------HENVVKFYG--HRREGNIQYLFLE 85 Query: 154 YVDNVDFRILYP---KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 Y + + + + + + +L+ + Y H +GI HRD+KP N+++D ++ L Sbjct: 86 YCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVYLHGIGITHRDIKPENLLLDERD-NL 144 Query: 211 RLIDWGLAEFYHVNME---YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 ++ D+GLA + N N + + PELL + +D+WS G +L +M+ Sbjct: 145 KISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAG 204 Query: 268 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGN 327 P+ + + + W N Sbjct: 205 ELPWDQPSDSCQEY-----------------------------------SDWKEKKTYLN 229 Query: 328 KHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + + L+ +L + R+T + W+ Sbjct: 230 PWKKIDSAPLALLHKILVENPSARITIPDIKKDRWY 265 >5L6P-A nrPDB Length = 298 Score = 183 bits (465), Expect = 9e-47, Method: Composition-based stats. Identities = 62/345 (17%), Positives = 127/345 (36%), Gaps = 80/345 (23%) Query: 25 DYENTVIDW--STNTKDYEIENKVGRGKYSEVFQGVKLDSKVK---IVIKMLKPVKKKK- 78 D V ++ + +IE +G G++ EV +G + + IK LK ++ Sbjct: 4 DPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQ 63 Query: 79 ---IKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIH 135 E I+ H NII Sbjct: 64 RRDFLSEASIMGQ---------------------------------------FDHPNIIR 84 Query: 136 LFDIIKDPISKTPALVFEYVDNVDF----RILYPKLTDLEIRFYMFELLKALDYCHSMGI 191 L ++ S+ ++ E+++N R+ + T +++ + + + Y M Sbjct: 85 LEGVVTK--SRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNY 142 Query: 192 MHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHV---NMEYNVRVASRF---FKGPELLVDY 245 +HRD+ N++++ N ++ D+GL+ F + Y + + + PE + Y Sbjct: 143 VHRDLAARNILVNS-NLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIA-Y 200 Query: 246 RMYDYSLDLWSFGTMLAS-MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 R + + D+WS+G ++ M + P++ SN D + + + Y L + Sbjct: 201 RKFTSASDVWSYGIVMWEVMSYGERPYWD-MSNQDVINAV--------EQDYRLPPPMDC 251 Query: 305 PREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQ 349 P + Q + W R N K +I++ +D L+R + Sbjct: 252 PTALH---QLMLDCWVRDRNLRPKF----SQIVNTLDKLIR-NPA 288 >2DQ7-X nrPDB Length = 283 Score = 183 bits (465), Expect = 9e-47, Method: Composition-based stats. Identities = 53/316 (16%), Positives = 115/316 (36%), Gaps = 67/316 (21%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--VKKKKIKREIKILTDLS 90 W + ++ ++G G++ EV+ G + K+ IK LKP + + E +I+ L Sbjct: 4 WEIPRESLQLIKRLGNGQFGEVWMGTW-NGNTKVAIKTLKPGTMSPESFLEEAQIMKKLK 62 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 ++K+ + L+ ++ + + + Sbjct: 63 HDKL---------------------------------------VQLYAVVSE---EPIYI 80 Query: 151 VFEYVDNVDFRILYP-----KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 V EY++ L + ++ + Y M +HRD++ N+++ + Sbjct: 81 VTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGN 140 Query: 206 KNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLA 262 ++ D+GLA N EY R ++F + PE + Y + D+WSFG +L Sbjct: 141 -GLICKIADFGLARLIEDN-EYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLT 197 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 ++ K + G +N + L ++ + Y + P + + + W + Sbjct: 198 ELVTKGRVPYPGMNNREVLEQVER--------GYRMPCPQDCP---ISLHELMIHCWKKD 246 Query: 323 INDGNKHLSGNDEIID 338 + + D Sbjct: 247 PEERPTFEYLQSFLED 262 >5SYS-A nrPDB Length = 286 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 62/351 (17%), Positives = 123/351 (35%), Gaps = 94/351 (26%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--VKKKKIKREIKILTDLS 90 W + +E K+G+G + E + G + ++ IK LKP + + +E +++ L Sbjct: 13 WEIPRESLRLEVKLGQGCFGECWMGTWNGT-TRVAIKTLKPGTMSPEAFLQEAQVMKKLR 71 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 +EK+ + L+ ++ + + + Sbjct: 72 HEKL---------------------------------------VQLYAVVSE---EPIYI 89 Query: 151 VFEYVDNVDFRILY-----PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 V EY+ L ++ ++ + Y M +HRD++ N+++ Sbjct: 90 VTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG- 148 Query: 206 KNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLA 262 +N ++ D+GLA N EY R ++F + PE + Y + D+WSFG +L Sbjct: 149 ENLVCKVADFGLARLIEDN-EYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLT 206 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 + K + G N + L ++ + Y + P + Sbjct: 207 ELTTKGRVPYPGMVNREVLDQVER--------GYRMPCPPECPESLH------------- 245 Query: 323 INDGNKHLSGNDEIIDLIDNLLRYDHQERLTAK--EAMGHPWFAPIREQIE 371 DL+ R D +ER T + +A +F Q + Sbjct: 246 ---------------DLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQ 281 >4XUF-A nrPDB Length = 297 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 59/332 (17%), Positives = 117/332 (35%), Gaps = 80/332 (24%) Query: 31 IDWSTNTKDYEIENKVGRGKYSEVFQGV-----KLDSKVKIVIKMLKPV----KKKKIKR 81 + W ++ E +G G + +V K +++ +KMLK +++ + Sbjct: 2 LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMS 61 Query: 82 EIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIK 141 E+K++T L H NI++L Sbjct: 62 ELKMMTQL--------------------------------------GSHENIVNLLGACT 83 Query: 142 DPISKTPALVFEYVDNVD----FRILYPKLTDLEIRF----------------------Y 175 +S L+FEY D R K ++ EI + + Sbjct: 84 --LSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEEEEDLNVLTFEDLLCF 141 Query: 176 MFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF 235 +++ K +++ +HRD+ NV++ H K +++ D+GLA + Y VR +R Sbjct: 142 AYQVAKGMEFLEFKSCVHRDLAARNVLVTH-GKVVKICDFGLARDIMSDSNYVVRGNARL 200 Query: 236 ---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSD 292 + PE L + +Y D+WS+G +L + + G K+++ D Sbjct: 201 PVKWMAPESLFE-GIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMD 259 Query: 293 FEKYLLKYEITLPREFYDMDQYIRKPWHRFIN 324 Y + + + + D R + + Sbjct: 260 QPFYATEEIYIIMQSCWAFDSRKRPSFPNLTS 291 >4GS6-A nrPDB Length = 315 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 64/337 (18%), Positives = 121/337 (35%), Gaps = 76/337 (22%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML-KPVKKKKIKREIKILTDLSNEK 93 + K+ E+E VGRG + V + + IK + ++K E++ L+ ++ Sbjct: 6 IDYKEIEVEEVVGRGAFGVVCKAKWR--AKDVAIKQIESESERKAFIVELRQLSRVN--- 60 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 H NI+ L+ +P LV E Sbjct: 61 ------------------------------------HPNIVKLYGACLNP----VCLVME 80 Query: 154 YVDNVDFRILY------PKLTDLEIRFYMFELLKALDYCHSMG---IMHRDVKPHNVMID 204 Y + + P T + + + + Y HSM ++HRD+KP N+++ Sbjct: 81 YAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLV 140 Query: 205 HKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASM 264 L++ D+G A + S + PE+ + Y D++S+G +L + Sbjct: 141 AGGTVLKICDFGTACDIQTH--MTNNKGSAAWMAPEV-FEGSNYSEKCDVFSWGIILWEV 197 Query: 265 IFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIN 324 I +R+PF +G F + T P ++ + I R + Sbjct: 198 ITRRKPF--------------DEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWS 243 Query: 325 DGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHP 361 +EI+ ++ +L+RY A E + +P Sbjct: 244 KDPSQRPSMEEIVKIMTHLMRYFP----GADEPLQYP 276 >1U5R-A nrPDB Length = 348 Score = 183 bits (463), Expect = 1e-46, Method: Composition-based stats. Identities = 57/350 (16%), Positives = 113/350 (32%), Gaps = 81/350 (23%) Query: 19 RTEEYWDYENTVIDWSTNTKD-YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKK 77 R D + + + + + + ++G G + V+ + + + IK + Sbjct: 34 RAGSLKDPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS----- 88 Query: 78 KIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLF 137 Y Q + + I + H N I Sbjct: 89 ----------------------------YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYR 120 Query: 138 DIIKDPISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHR 194 T LV EY + L ++EI L+ L Y HS ++HR Sbjct: 121 GCYLR--EHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHR 178 Query: 195 DVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLV--DYRMYDYSL 252 DVK N+++ ++L D+G A N V + ++ PE+++ D YD + Sbjct: 179 DVKAGNILLSEPGL-VKLGDFGSASIMAP---ANSFVGTPYWMAPEVILAMDEGQYDGKV 234 Query: 253 DLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMD 312 D+WS G + ++ P F+ + L I + + + Sbjct: 235 DVWSLGITCIELAERKPPLFN-MNAMSALYHIAQNESPALQSGHW--------------- 278 Query: 313 QYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 ++ + +D+ L+ Q+R T++ + H + Sbjct: 279 --------------------SEYFRNFVDSCLQKIPQDRPTSEVLLKHRF 308 >2I0E-A nrPDB Length = 353 Score = 183 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 55/345 (15%), Positives = 109/345 (31%), Gaps = 83/345 (24%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 93 D+ +G+G + +V + + +K+LK Sbjct: 16 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKD------------------- 56 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 Q +DV + + L V E Sbjct: 57 -------------VVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCF--QTMDRLYFVME 101 Query: 154 YVDNVDFRILYP---KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 YV+ D + + FY E+ L + S GI++RD+K NVM+D + + Sbjct: 102 YVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEG-HI 160 Query: 211 RLIDWGLAEF-YHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 ++ D+G+ + + + + PE++ Y+ Y S+D W+FG +L M+ + Sbjct: 161 KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIA-YQPYGKSVDWWAFGVLLYEMLAGQA 219 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 PF G + I++ + + P+ Sbjct: 220 PF-EGEDEDELFQSIME-------------HNVAYPKSM--------------------- 244 Query: 330 LSGNDEIIDLIDNLLRYDHQERLTA-----KEAMGHPWFAPIREQ 369 + E + + L+ +RL ++ H +F I + Sbjct: 245 ---SKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWE 286 >4F9B-A nrPDB Length = 361 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 84/377 (22%), Positives = 151/377 (40%), Gaps = 90/377 (23%) Query: 40 YEIENKVGRGKYSEVFQGV---KLDSKVKIVIKMLKPVKKK-KIKREIKILTDLSNEKVP 95 ++IE+K+G G +S V+ ++ + KI +K L P +I E++ LT Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPIRIAAELQCLT-------- 74 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 G N++ + + + + Y+ Sbjct: 75 ------------------------------VAGGQDNVMGVKYCFRK--NDHVVIAMPYL 102 Query: 156 DNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDW 215 ++ F + L+ E+R YM L KAL H GI+HRDVKP N + + + KK L+D+ Sbjct: 103 EHESFLDILNSLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDF 162 Query: 216 GLAEFYHVN-----------------------------MEYNVRVASRFFKGPELLVDYR 246 GLA+ H + R + F+ PE+L Sbjct: 163 GLAQGTHDTKIELLKFVQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCP 222 Query: 247 MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSD-------FEKYLLK 299 ++D+WS G + S++ R PF+ + + L +I+ + G+ + F K +L Sbjct: 223 NQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILC 282 Query: 300 YEITLPREFYDMDQYIR---KPWHRFINDGNKHLSG-------NDEIIDLIDNLLRYDHQ 349 + ++ + + +R + +D H + DE DL+D LL + Sbjct: 283 SKEVPAQDLRKLCERLRGMDSSTPKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPA 342 Query: 350 ERLTAKEAMGHPWFAPI 366 R+TA+EA+ HP+F + Sbjct: 343 SRITAEEALLHPFFKDM 359 >3BEA-A nrPDB Length = 333 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 56/327 (17%), Positives = 110/327 (33%), Gaps = 81/327 (24%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGV-----KLDSKVKIVIKMLKPV----KKKKIKRE 82 W + + +G G + +V + K D+ +K+ +KMLK +K+ + E Sbjct: 40 KWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSE 99 Query: 83 IKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD 142 +KI++ L H NI++L Sbjct: 100 LKIMSHL--------------------------------------GQHENIVNLLGACTH 121 Query: 143 PISKTPALVFEYVDNVDFRILYPK-----------------LTDLEIRFYMFELLKALDY 185 ++ EY D + L+ ++ + ++ + + + Sbjct: 122 --GGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSSQVAQGMAF 179 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELL 242 S +HRDV NV++ + ++ D+GLA + Y V+ +R + PE + Sbjct: 180 LASKNCIHRDVAARNVLLTN-GHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESI 238 Query: 243 VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEI 302 D +Y D+WS+G +L + + G + K+VK + Y + Sbjct: 239 FDC-VYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK-------DGYQMAQPA 290 Query: 303 TLPREFYDMDQYIRKPWHRFINDGNKH 329 P+ Y + Q W Sbjct: 291 FAPKNIYSIMQ---ACWALEPTHRPTF 314 >6CQF-A nrPDB Length = 297 Score = 182 bits (461), Expect = 2e-46, Method: Composition-based stats. Identities = 58/334 (17%), Positives = 118/334 (35%), Gaps = 84/334 (25%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK---PVKKKKIKREIKILTDLSNE 92 Y++ ++G G Y EVF+ S + +KM+K +++EI IL Sbjct: 14 PRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCR-- 71 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF 152 HANI+ + + Sbjct: 72 -------------------------------------HANIVAYHGSYL--WLQKLWICM 92 Query: 153 EYVDNVDFRILYP---KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 E+ + +Y L++L+I + E+L+ L Y HS +HRD+K N++I+ + Sbjct: 93 EFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAG-E 151 Query: 210 LRLIDWGLAEFYHVNMEYN-VRVASRFFKGPEL--LVDYRMYDYSLDLWSFGTMLASMIF 266 +RL D+G++ + + + ++ PE+ + Y+ D+WS G + Sbjct: 152 VRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAE 211 Query: 267 KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG 326 + P F ++++ ++ S ++ LK + F++ Sbjct: 212 LQPPLFDVHP-----LRVLFLMTKSGYQPPRLKEKGKWSAAFHN---------------- 250 Query: 327 NKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGH 360 I L ++R +A + + H Sbjct: 251 ------------FIKVTLTKSPKKRPSATKMLSH 272 >3KUL-B nrPDB Length = 325 Score = 182 bits (461), Expect = 2e-46, Method: Composition-based stats. Identities = 63/353 (17%), Positives = 122/353 (34%), Gaps = 77/353 (21%) Query: 20 TEEYWDYENTVIDW--STNTKDYEIENKVGRGKYSEVFQGVKLDSKVK---IVIKMLKPV 74 Y + + IE +G G EV G + + IK LK Sbjct: 29 PHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAG 88 Query: 75 KKKK----IKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGH 130 ++ E I+ H Sbjct: 89 YTERQRRDFLSEASIMGQ---------------------------------------FDH 109 Query: 131 ANIIHLFDIIKDPISKTPALVFEYVDNVDF----RILYPKLTDLEIRFYMFELLKALDYC 186 NII L ++ + +V EY++N R + T +++ + + + Y Sbjct: 110 PNIIRLEGVVTR--GRLAMIVTEYMENGSLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYL 167 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME--YNVRVASRF--FKGPELL 242 +G +HRD+ NV++D N ++ D+GL+ + + Y + PE + Sbjct: 168 SDLGYVHRDLAARNVLVDS-NLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAI 226 Query: 243 VDYRMYDYSLDLWSFGTMLAS-MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYE 301 +R + + D+WSFG ++ + + P+++ +N D + + E Y L Sbjct: 227 A-FRTFSSASDVWSFGVVMWEVLAYGERPYWN-MTNRDVISSV--------EEGYRLPAP 276 Query: 302 ITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTA 354 + P + + Q + WH+ + +I+ ++D L+R R TA Sbjct: 277 MGCP---HALHQLMLDCWHKDRAQRPRF----SQIVSVLDALIRSPESLRATA 322 >4XEY-B nrPDB Length = 408 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 48/308 (15%), Positives = 110/308 (35%), Gaps = 65/308 (21%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--VKKKKIKREIKILTDL 89 W D +++K+G G+Y EV++GV + + +K LK ++ ++ +E ++ ++ Sbjct: 119 KWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEI 178 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 H N++ L + Sbjct: 179 K---------------------------------------HPNLVQLLGVCTR--EPPFY 197 Query: 150 LVFEYVDNVDFRILYPKLTDLEI-----RFYMFELLKALDYCHSMGIMHRDVKPHNVMID 204 ++ E++ + + E+ + ++ A++Y +HRD+ N ++ Sbjct: 198 IITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG 257 Query: 205 HKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTML 261 +N +++ D+GL+ Y ++F + PE L Y + D+W+FG +L Sbjct: 258 -ENHLVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLL 314 Query: 262 ASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 + + G + + K Y ++ P + Y++ +R W Sbjct: 315 WEIATYGMSPYPGIDLSQVYELLEK--------DYRMERPEGCPEKVYEL---MRACWQW 363 Query: 322 FINDGNKH 329 +D Sbjct: 364 NPSDRPSF 371 >2FO0-A nrPDB Length = 495 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 47/308 (15%), Positives = 110/308 (35%), Gaps = 65/308 (21%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--VKKKKIKREIKILTDL 89 W D +++K+G G+Y EV++GV + + +K LK ++ ++ +E ++ ++ Sbjct: 211 KWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEI 270 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 H N++ L + Sbjct: 271 K---------------------------------------HPNLVQLLGVCTR--EPPFY 289 Query: 150 LVFEYVDNVDFRILYPKLTDLEI-----RFYMFELLKALDYCHSMGIMHRDVKPHNVMID 204 ++ E++ + + E+ + ++ A++Y +HR++ N ++ Sbjct: 290 IITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRNLAARNCLVG 349 Query: 205 HKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTML 261 +N +++ D+GL+ Y ++F + PE L Y + D+W+FG +L Sbjct: 350 -ENHLVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLL 406 Query: 262 ASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 + + G + + K Y ++ P + Y++ +R W Sbjct: 407 WEIATYGMSPYPGIDLSQVYELLEK--------DYRMERPEGCPEKVYEL---MRACWQW 455 Query: 322 FINDGNKH 329 +D Sbjct: 456 NPSDRPSF 463 >4EBW-A nrPDB Length = 304 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 52/327 (15%), Positives = 111/327 (33%), Gaps = 68/327 (20%) Query: 28 NTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKL---DSKVKIVIKMLKP----VKKKKIK 80 ++ D+ + E+ +G G++ +V QG+ + + + + IK K ++K Sbjct: 28 SSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFL 87 Query: 81 REIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII 140 +E + H +I+ L +I Sbjct: 88 QEALTMRQ---------------------------------------FDHPHIVKLIGVI 108 Query: 141 KDPISKTPALVFEYVDNVDFRILYP----KLTDLEIRFYMFELLKALDYCHSMGIMHRDV 196 ++ E + R L + Y ++L AL Y S +HRD+ Sbjct: 109 ---TENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDI 165 Query: 197 KPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF--FKGPELLVDYRMYDYSLDL 254 NV++ + ++L D+GL+ + + Y + PE + ++R + + D+ Sbjct: 166 AARNVLVSSNDC-VKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESI-NFRRFTSASDV 223 Query: 255 WSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQY 314 W FG + ++ F G N D + +I L P Y + Sbjct: 224 WMFGVCMWEILMHGVKPFQGVKNNDVIGRIEN--------GERLPMPPNCPPTLYSL--- 272 Query: 315 IRKPWHRFINDGNKHLSGNDEIIDLID 341 + K W + + ++ +++ Sbjct: 273 MTKCWAYDPSRRPRFTELKAQLSTILE 299 >6BDL-A nrPDB Length = 347 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 66/347 (19%), Positives = 123/347 (35%), Gaps = 94/347 (27%) Query: 38 KDYEIENKVGRGKYSEVFQG-VKLDSKVKIVIKMLKPVK------KKKIKREIKILTDLS 90 D+ I + +G G + V +K + +K+LK ++ I+ E +I+ Sbjct: 34 SDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAH 93 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 ++ I+ L+ KD SK + Sbjct: 94 SDF---------------------------------------IVRLYRTFKD--SKYLYM 112 Query: 151 VFEYVDNVDFRIL---YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN 207 + E + + D RFY +++A Y HS GI++RD+KP N+++DH+ Sbjct: 113 LMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGIIYRDLKPENLILDHRG 172 Query: 208 KKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 +L+D+G A+ + + + PE++++ + +D S D WS G ++ ++ Sbjct: 173 YA-KLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILN-KGHDISADYWSLGILMYELLTG 230 Query: 268 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGN 327 PF G I++ + +F K + K Sbjct: 231 SPPF-SGPDPMKTYNIILRGIDMIEFPKKIAKN--------------------------- 262 Query: 328 KHLSGNDEIIDLIDNLLRYDHQERL-----TAKEAMGHPWFAPIREQ 369 +LI L R + ERL K+ H WF + Sbjct: 263 --------AANLIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWE 301 >2OGV-A nrPDB Length = 317 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 56/323 (17%), Positives = 109/323 (33%), Gaps = 77/323 (23%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGV-----KLDSKVKIVIKMLKPV----KKKKIKRE 82 W + + +G G + +V + K D+ +K+ +KMLK +K+ + E Sbjct: 32 KWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSE 91 Query: 83 IKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD 142 +KI++ L H NI++L Sbjct: 92 LKIMSHL--------------------------------------GQHENIVNLLGACTH 113 Query: 143 PISKTPALVFEYVDNVDFRILYPK-------------LTDLEIRFYMFELLKALDYCHSM 189 ++ EY D + L ++ + ++ + + + S Sbjct: 114 --GGPVLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVAQGMAFLASK 171 Query: 190 GIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYR 246 +HRDV NV++ + ++ D+GLA + Y V+ +R + PE + D Sbjct: 172 NCIHRDVAARNVLLTN-GHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDC- 229 Query: 247 MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPR 306 +Y D+WS+G +L + + G + K+VK + Y + P+ Sbjct: 230 VYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK-------DGYQMAQPAFAPK 282 Query: 307 EFYDMDQYIRKPWHRFINDGNKH 329 Y + Q W Sbjct: 283 NIYSIMQ---ACWALEPTHRPTF 302 >3LM0-A nrPDB Length = 327 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 55/330 (16%), Positives = 120/330 (36%), Gaps = 79/330 (23%) Query: 44 NKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK-KKIKREIKILTDLSNEKVPPTTLPFQ 102 ++GRGK++ V Q + + + K LK ++ + + EI Sbjct: 35 KELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEI------------------- 75 Query: 103 KDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVD--- 159 + VL+ + +I+L ++ ++ L+ EY + Sbjct: 76 ------LHEIAVLELAKSC---------PRVINLHEVYENTSE--IILILEYAAGGEIFS 118 Query: 160 --FRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH--KNKKLRLIDW 215 L +++ ++ + ++L+ + Y H I+H D+KP N+++ ++++D+ Sbjct: 119 LCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDF 178 Query: 216 GLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGT 275 G++ E + + + PE+L +Y + D+W+ G + ++ PF G Sbjct: 179 GMSRKIGHACELREIMGTPEYLAPEIL-NYDPITTATDMWNIGIIAYMLLTHTSPFV-GE 236 Query: 276 SNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDE 335 N + + I +V E S + Sbjct: 237 DNQETYLNISQVNVDYSEE---------------------------------TFSSVSQL 263 Query: 336 IIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 D I +LL + ++R TA+ + H W Sbjct: 264 ATDFIQSLLVKNPEKRPTAEICLSHSWLQQ 293 >3QA8-A nrPDB Length = 676 Score = 181 bits (459), Expect = 4e-46, Method: Composition-based stats. Identities = 56/246 (22%), Positives = 98/246 (39%), Gaps = 48/246 (19%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKM----LKPVKKKKIKREIKILTDLSNEKVP 95 +E++ ++G G + V + + D+ ++ IK L P +++ EI+I+ L++ V Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKLNHPNVV 75 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 + D N P L EY Sbjct: 76 S----------------------AREVPDGLQKLAPN-------------DLPLLAMEYC 100 Query: 156 DNVDFRILYPK------LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 + D R + L + IR + ++ AL Y H I+HRD+KP N+++ ++ Sbjct: 101 EGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALRYLHENRIIHRDLKPENIVLQPGPQR 160 Query: 210 L--RLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 L ++ID G A+ V + + PELL + + Y ++D WSFGT+ I Sbjct: 161 LIHKIIDLGYAKELDQGELCTEFVGTLQYLAPELL-EQKKYTVTVDYWSFGTLAFECITG 219 Query: 268 REPFFH 273 PF Sbjct: 220 FRPFLP 225 >2HK5-A nrPDB Length = 270 Score = 181 bits (459), Expect = 4e-46, Method: Composition-based stats. Identities = 47/317 (14%), Positives = 113/317 (35%), Gaps = 67/317 (21%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--VKKKKIKREIKILTDLS 90 W + ++E K+G G++ EV+ K+ +K +KP + + E ++ L Sbjct: 10 WEIPRESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPGSMSVEAFLAEANVMKTLQ 68 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 ++K+ + L ++ + + Sbjct: 69 HDKL---------------------------------------VKLHAVV---TKEPIYI 86 Query: 151 VFEYVDNVDFRILYP-----KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 + E++ K ++ + ++ + + + +HRD++ N+++ Sbjct: 87 ITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSA 146 Query: 206 KNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLA 262 + ++ D+GLA N EY R ++F + PE + ++ + D+WSFG +L Sbjct: 147 -SLVCKIADFGLARVIEDN-EYTAREGAKFPIKWTAPEAI-NFGSFTIKSDVWSFGILLM 203 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 ++ + G SN + + + + Y + P E Y++ + + W Sbjct: 204 EIVTYGRIPYPGMSNPEVIRALER--------GYRMPRPENCPEELYNI---MMRCWKNR 252 Query: 323 INDGNKHLSGNDEIIDL 339 + + D Sbjct: 253 PEERPTFEYIQSVLDDF 269 >2WQN-A nrPDB Length = 310 Score = 181 bits (459), Expect = 5e-46, Method: Composition-based stats. Identities = 59/298 (19%), Positives = 107/298 (35%), Gaps = 45/298 (15%) Query: 39 DYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTT 98 ++ IE K+GRG++SEV++ L V + +K ++ K + ++ Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKARADCIKEID-------- 84 Query: 99 LPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNV 158 H N+I + + +V E D Sbjct: 85 -------------------------LLKQLNHPNVIKYYASFIE--DNELNIVLELADAG 117 Query: 159 DFRILYPKL-------TDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 D + + + Y +L AL++ HS +MHRD+KP NV I ++ Sbjct: 118 DLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATG-VVK 176 Query: 212 LIDWGLAEFYHVNMEY-NVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 L D GL F+ + V + ++ PE + + Y++ D+WS G +L M + P Sbjct: 177 LGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHE-NGYNFKSDIWSLGCLLYEMAALQSP 235 Query: 271 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 F+ N L K ++ E+ ++P ++ D K Sbjct: 236 FYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAK 293 >2GCD-A nrPDB Length = 309 Score = 180 bits (457), Expect = 8e-46, Method: Composition-based stats. Identities = 56/344 (16%), Positives = 112/344 (32%), Gaps = 81/344 (23%) Query: 25 DYENTVIDWSTNTKD-YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREI 83 D + + + + + + ++G G + V+ + + + IK + Sbjct: 1 DPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMS----------- 49 Query: 84 KILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP 143 Y Q + + I + H N I Sbjct: 50 ----------------------YSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLR- 86 Query: 144 ISKTPALVFEYVDN---VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHN 200 T LV EY + L ++EI L+ L Y HS ++HRDVK N Sbjct: 87 -EHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGN 145 Query: 201 VMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLV--DYRMYDYSLDLWSFG 258 +++ ++L D+G A N V + ++ PE+++ D YD +D+WS G Sbjct: 146 ILLSEPGL-VKLGDFGSASIMAP---ANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLG 201 Query: 259 TMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKP 318 + ++ P F+ + L I + + + Sbjct: 202 ITCIELAERKPPLFN-MNAMSALYHIAQNESPALQSGHW--------------------- 239 Query: 319 WHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 ++ + +D+ L+ Q+R T++ + H + Sbjct: 240 --------------SEYFRNFVDSCLQKIPQDRPTSEVLLKHRF 269 >6NPU-A nrPDB Length = 298 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 48/308 (15%), Positives = 110/308 (35%), Gaps = 65/308 (21%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--VKKKKIKREIKILTDL 89 W D +++K+G G+Y EV++GV + + +K LK ++ ++ +E ++ ++ Sbjct: 20 KWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEI 79 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 H N++ L + Sbjct: 80 K---------------------------------------HPNLVQLLGVCTR--EPPFY 98 Query: 150 LVFEYVDNVDFRILYPKLTDLEI-----RFYMFELLKALDYCHSMGIMHRDVKPHNVMID 204 ++ E++ + + E+ + ++ A++Y +HRD+ N ++ Sbjct: 99 IITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVG 158 Query: 205 HKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTML 261 +N +++ D+GL+ Y ++F + PE L Y + D+W+FG +L Sbjct: 159 -ENHLVKVADFGLSRLM-TGDTYTAHAGAKFPIKWTAPESLA-YNKFSIKSDVWAFGVLL 215 Query: 262 ASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 + + G + + K Y ++ P + Y++ +R W Sbjct: 216 WEIATYGMSPYPGIDLSQVYELLEK--------DYRMERPEGCPEKVYEL---MRACWQW 264 Query: 322 FINDGNKH 329 +D Sbjct: 265 NPSDRPSF 272 >5HIE-A nrPDB Length = 302 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 56/325 (17%), Positives = 123/325 (37%), Gaps = 62/325 (19%) Query: 28 NTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILT 87 ++ DW + ++G G + V++G + +KML P + + K E+ +L Sbjct: 26 DSSDDWEIPDGQITVGQRIGSGSFGTVYKG---KWHGDVAVKMLTPQQLQAFKNEVGVLR 82 Query: 88 DLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKT 147 H NI+ P Sbjct: 83 K---------------------------------------TRHVNILLFMGYSTKPQ--- 100 Query: 148 PALVFEYVDNVDF----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI 203 A+V ++ + I+ K +++ + + +DY H+ I+HRD+K +N+ + Sbjct: 101 LAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFL 160 Query: 204 DHKNKKLRLIDWGLAEF---YHVNMEYNVRVASRFFKGPELL--VDYRMYDYSLDLWSFG 258 H++ +++ D+GLA + + ++ S + PE++ D Y + D+++FG Sbjct: 161 -HEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFG 219 Query: 259 TMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKP 318 +L ++ + P+ SN + +I+ ++G L K P+ M + + + Sbjct: 220 IVLYELMTGQLPY----SNINNRDQIIFMVGRGYLSPDLSKVRSNCPKA---MKRLMAEC 272 Query: 319 WHRFINDGNKHLSGNDEIIDLIDNL 343 + ++ I L +L Sbjct: 273 LKKKRDERPLFPQILASIELLARSL 297 >3KRL-A nrPDB Length = 335 Score = 179 bits (455), Expect = 1e-45, Method: Composition-based stats. Identities = 56/329 (17%), Positives = 110/329 (33%), Gaps = 83/329 (25%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGV-----KLDSKVKIVIKMLKPV----KKKKIKRE 82 W + + +G G + +V + K D+ +K+ +KMLK +K+ + E Sbjct: 40 KWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSE 99 Query: 83 IKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD 142 +KI++ L H NI++L Sbjct: 100 LKIMSHL--------------------------------------GQHENIVNLLGACTH 121 Query: 143 PISKTPALVFEYVDNVDFRILYPK-------------------LTDLEIRFYMFELLKAL 183 ++ EY D + L+ ++ + ++ + + Sbjct: 122 --GGPVLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGM 179 Query: 184 DYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPE 240 + S +HRDV NV++ + ++ D+GLA + Y V+ +R + PE Sbjct: 180 AFLASKNCIHRDVAARNVLLTN-GHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPE 238 Query: 241 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 300 + D +Y D+WS+G +L + + G + K+VK + Y + Sbjct: 239 SIFDC-VYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK-------DGYQMAQ 290 Query: 301 EITLPREFYDMDQYIRKPWHRFINDGNKH 329 P+ Y + Q W Sbjct: 291 PAFAPKNIYSIMQ---ACWALEPTHRPTF 316 >3NYO-A nrPDB Length = 576 Score = 179 bits (455), Expect = 1e-45, Method: Composition-based stats. Identities = 70/357 (19%), Positives = 119/357 (33%), Gaps = 87/357 (24%) Query: 26 YENTVIDWS------TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKI 79 Y N + W + +G+G + EV + K L+ + KK Sbjct: 166 YFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKR 225 Query: 80 KREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDI 139 K E L + + + F Y + +D L Sbjct: 226 KGEAMALNE--KQILEKVNSRFVVSLAYAYETKDAL------------------------ 259 Query: 140 IKDPISKTPALVFEYVDNVDFRILY-----PKLTDLEIRFYMFELLKALDYCHSMGIMHR 194 LV ++ D + + FY E+ L+ H I++R Sbjct: 260 ---------CLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYR 310 Query: 195 DVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDL 254 D+KP N+++D + +R+ D GLA RV + + PE++ + R Y +S D Sbjct: 311 DLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNER-YTFSPDW 368 Query: 255 WSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQY 314 W+ G +L MI + PF Q K +K + + + +P E+ + Sbjct: 369 WALGCLLYEMIAGQSPF-------QQRKKKIKR-------EEVERLVKEVPEEYSE---- 410 Query: 315 IRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERL-----TAKEAMGHPWFAPI 366 + + L LL D ERL +A+E HP F + Sbjct: 411 ----------------RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKL 451 >2J0K-A nrPDB Length = 656 Score = 179 bits (454), Expect = 1e-45, Method: Composition-based stats. Identities = 55/356 (15%), Positives = 117/356 (32%), Gaps = 73/356 (20%) Query: 4 RVWSEARVYTNINKQRTEEYWDYEN-----TVIDWSTNTKDYEIENKVGRGKYSEVFQGV 58 + + + E D E+ + D+ + E+ +G G++ +V QG+ Sbjct: 351 KQGVRSHTVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGI 410 Query: 59 KL---DSKVKIVIKMLKP----VKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQK 111 + + + + IK K ++K +E + Sbjct: 411 YMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQ----------------------- 447 Query: 112 EDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYP----KL 167 H +I+ L +I ++ E + R L Sbjct: 448 ----------------FDHPHIVKLIGVI---TENPVWIIMELCTLGELRSFLQVRKFSL 488 Query: 168 TDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEY 227 + Y ++L AL Y S +HRD+ NV++ + ++L D+GL+ + + Y Sbjct: 489 DLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSATDC-VKLGDFGLSRYMEDSTYY 547 Query: 228 NVRVASRF--FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIV 285 + PE + ++R + + D+W FG + ++ F G N D + +I Sbjct: 548 KASKGKLPIKWMAPESI-NFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIE 606 Query: 286 KVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLID 341 L P Y + + K W + + ++ +++ Sbjct: 607 N--------GERLPMPPNCPPTLYSL---MTKCWAYDPSRRPRFTELKAQLSTILE 651 >5TUR-A nrPDB Length = 404 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 66/337 (19%), Positives = 119/337 (35%), Gaps = 79/337 (23%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 93 Y++ +G G + V+ G+++ + + IK ++ K I +L N Sbjct: 123 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVE-------KDRISDWGELPNGT 175 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 P + K +I L D + P S L+ E Sbjct: 176 RVPMEVVLLKKVSSGFSG---------------------VIRLLDWFERPDSF--VLILE 212 Query: 154 Y----VDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 D DF L + R + +++L+A+ +CH+ G++HRD+K N++ID + Sbjct: 213 RPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE 272 Query: 210 LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 L+LID+G + Y +R + PE + +R + S +WS G +L M+ Sbjct: 273 LKLIDFGSGALLK-DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI 331 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 PF H +++ ++ + Sbjct: 332 PFEHDEE--------------------IIRGQVFFRQRV--------------------- 350 Query: 330 LSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPI 366 + E LI L +R T +E HPW + Sbjct: 351 ---SSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 384 >4I6B-A nrPDB Length = 308 Score = 179 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 56/341 (16%), Positives = 125/341 (36%), Gaps = 91/341 (26%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML------KPVKKKKIKREIKILTD 88 T K Y +G+G +++ ++ L + K++ KP +++KI +EI++ Sbjct: 25 TTGKRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRI 84 Query: 89 LSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTP 148 L H +++ + +D + Sbjct: 85 LH---------------------------------------HKHVVQFYHYFED--KENI 103 Query: 149 ALVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 ++ EY + LT+ E+R+Y+ +++ L Y H I+HRD+K N I+ Sbjct: 104 YILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFIN- 162 Query: 206 KNKKLRLIDWGLAEFYHV-NMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASM 264 ++ +L++ D+GLA + + PE+L + + + D+W+ G ++ +M Sbjct: 163 ESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL-NKQGHGAESDIWALGCVMYTM 221 Query: 265 IFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIN 324 + R PF + + + + +Y + + P Sbjct: 222 LLGRPPF--------ETTNLKETYRSIREARYTMPSSLLAP------------------- 254 Query: 325 DGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 LI ++L + ++R + + + H +F Sbjct: 255 -----------AKHLIASMLSKNPEDRPSLDDIIRHDFFTQ 284 >4KIK-B nrPDB Length = 677 Score = 179 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 63/336 (18%), Positives = 117/336 (34%), Gaps = 82/336 (24%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKM----LKPVKKKKIKREIKILTDLSNEKVP 95 +E++ ++G G + V + ++ +I IK L P +++ EI+I+ L+ Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLT----- 75 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP----ISKTPALV 151 H N++ D+ + + P L Sbjct: 76 ----------------------------------HPNVVAARDVPEGMQNLAPNDLPLLA 101 Query: 152 FEYVDNVDFRILYPK------LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 EY D R + L + I + ++ AL Y H I+HRD+KP N+++ Sbjct: 102 MEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQ 161 Query: 206 KNKKL--RLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLAS 263 ++L ++ID G A+ V + + PELL + + Y ++D WSFGT+ Sbjct: 162 GEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELL-EQQKYTVTVDYWSFGTLAFE 220 Query: 264 MIFKREPFFH------GTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRK 317 I PF S Q ++ V+ + P + + Sbjct: 221 CITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLE 280 Query: 318 PWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLT 353 W + +L + ++R T Sbjct: 281 KW--------------------LQLMLMWHPRQRGT 296 >5GRN-A nrPDB Length = 356 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 68/348 (19%), Positives = 132/348 (37%), Gaps = 42/348 (12%) Query: 10 RVYTNINKQRTEE-YWDYENTVID--WSTNTKDYEIENKVGRGKYSEVFQGV-----KLD 61 RV +I+ E Y D D W + +G G + +V +G + Sbjct: 15 RVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQ 74 Query: 62 SKVKIVIKMLKPV----KKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKF 117 +K+ +KMLKP +K+ + E+KI+T L L K + Sbjct: 75 PVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLL-------GACTKSGPIYI 127 Query: 118 IRPYIF--DQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFY 175 I Y F D + H N D K +++ V N+ LT L++ + Sbjct: 128 ITEYCFYGDLVNYLHKN----RDSFLS--HKKKSMLDSEVKNLLSDDNSEGLTLLDLLSF 181 Query: 176 MFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVAS-- 233 +++ + +++ S +HRD+ NV++ + K +++ D+GLA + Y + ++ Sbjct: 182 TYQVARGMEFLASKNCVHRDLAARNVLL-AQGKIVKICDFGLARDIMHDSNYVSKGSTFL 240 Query: 234 -RFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSD 292 + PE + D +Y D+WS+G +L + + G +K Sbjct: 241 PVKWMAPESIFD-NLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKS----- 294 Query: 293 FEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLI 340 Y + E Y++ + K W+ ++ + +L+ Sbjct: 295 --GYRMAKPDHATSEVYEI---MVKCWNSEPEKRPSFYHLSEIVENLL 337 >4FR4-A nrPDB Length = 384 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 60/346 (17%), Positives = 130/346 (37%), Gaps = 89/346 (25%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK------IKREIKILTD 88 N +EI +G+G + +V K D+K +K + K + + +E++I+ Sbjct: 12 VNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVFKELQIMQG 71 Query: 89 LSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTP 148 L + PF + +Y+ Q E+ + Sbjct: 72 LEH--------PFLVNLWYSFQDEEDM--------------------------------- 90 Query: 149 ALVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 +V + + D R + + ++ ++ EL+ ALDY + I+HRD+KP N+++D Sbjct: 91 FMVVDLLLGGDLRYHLQQNVHFKEETVKLFICELVMALDYLQNQRIIHRDMKPDNILLD- 149 Query: 206 KNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYR--MYDYSLDLWSFGTMLAS 263 ++ + + D+ +A + ++ + PE+ + Y +++D WS G Sbjct: 150 EHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSRKGAGYSFAVDWWSLGVTAYE 209 Query: 264 MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFI 323 ++ R P+ +S + + +IV T+ +T P + Sbjct: 210 LLRGRRPYHIRSSTSSK--EIVHTFETT---------VVTYPSAW--------------- 243 Query: 324 NDGNKHLSGNDEIIDLIDNLLRYDHQERLT-AKEAMGHPWFAPIRE 368 + E++ L+ LL + +R + + P+ I Sbjct: 244 ---------SQEMVSLLKKLLEPNPDQRFSQLSDVQNFPYMNDINW 280 >3BGP-A nrPDB Length = 333 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 66/337 (19%), Positives = 119/337 (35%), Gaps = 79/337 (23%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 93 Y++ +G G + V+ G+++ + + IK ++ K I +L N Sbjct: 52 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVE-------KDRISDWGELPNGT 104 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 P + K +I L D + P S L+ E Sbjct: 105 RVPMEVVLLKKVSSGFSG---------------------VIRLLDWFERPDSF--VLILE 141 Query: 154 Y----VDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 D DF L + R + +++L+A+ +CH+ G++HRD+K N++ID + Sbjct: 142 RPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE 201 Query: 210 LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 L+LID+G + Y +R + PE + +R + S +WS G +L M+ Sbjct: 202 LKLIDFGSGALLK-DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI 260 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 PF H +++ ++ + Sbjct: 261 PFEHDEE--------------------IIRGQVFFRQRV--------------------- 279 Query: 330 LSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPI 366 + E LI L +R T +E HPW + Sbjct: 280 ---SSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 313 >6DBM-A nrPDB Length = 318 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 66/346 (19%), Positives = 127/346 (36%), Gaps = 79/346 (22%) Query: 40 YEIENKVGRGKYSEV----FQGVKLDSKVKIVIKMLK----PVKKKKIKREIKILTDLSN 91 + +G G + +V + + + +K LK P + K+EI IL L Sbjct: 33 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDILRTL-- 90 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H +II +D + + LV Sbjct: 91 -------------------------------------YHEHIIKYKGCCEDAGAASLQLV 113 Query: 152 FEYVDNVDFRILYPKLT--DLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 EYV R P+ + ++ + ++ + + Y HS +HRD+ NV++D+ ++ Sbjct: 114 MEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHSQHYIHRDLAARNVLLDN-DRL 172 Query: 210 LRLIDWGLAEFYHVNMEYNVRV----ASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 +++ D+GLA+ EY + F+ PE L +Y+ Y Y+ D+WSFG L ++ Sbjct: 173 VKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFY-YASDVWSFGVTLYELL 231 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 H S+ K ++++G + + +L+ L R Sbjct: 232 T------HCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERG----------------ER 269 Query: 326 GNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIE 371 + E+ L+ N + R T + + P + E+ + Sbjct: 270 LPRPDKCPAEVYHLMKNCWETEASFRPTFENLI--PILKTVHEKYQ 313 >2WTK-C nrPDB Length = 305 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 63/340 (18%), Positives = 122/340 (35%), Gaps = 93/340 (27%) Query: 39 DYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK-------PVKKKKIKREIKILTDLSN 91 Y + + +G G Y +V + + ++ + +K+LK P + +K+EI++L L Sbjct: 6 KYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLR- 64 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H N+I L D++ + + +V Sbjct: 65 --------------------------------------HKNVIQLVDVLYNEEKQKMYMV 86 Query: 152 FEYVDNVDFRIL----YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN 207 EY +L + + Y +L+ L+Y HS GI+H+D+KP N+++ Sbjct: 87 MEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTT-G 145 Query: 208 KKLRLIDWGLAEFYHV---NMEYNVRVASRFFKGPELLVDYRMY-DYSLDLWSFGTMLAS 263 L++ G+AE H + S F+ PE+ + + +D+WS G L + Sbjct: 146 GTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYN 205 Query: 264 MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFI 323 + PF D + K+ + +G + Sbjct: 206 ITTGLYPF-----EGDNIYKLFENIGKGSY------------------------------ 230 Query: 324 NDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + DL+ +L Y+ +R + ++ H WF Sbjct: 231 ---AIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWF 267 >2JD5-A nrPDB Length = 373 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 72/347 (20%), Positives = 151/347 (43%), Gaps = 49/347 (14%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK--PVKKKKIKREIKILTDLSNEKVPPT 97 Y + K+G G +S V+ + + + +K+++ V + + EIK+L +++ Sbjct: 21 YILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTKE 80 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 + +LK + + P+ H ++ +F+++ + + AL+ +Y Sbjct: 81 D---------SMGANHILKLLDHFNHKGPNGVH--VVMVFEVLGENL---LALIKKY--- 123 Query: 158 VDFRILYPKLTDLEIRFYMFELLKALDYCHSM-GIMHRDVKPHNVMIDHKNK-----KLR 211 + + + ++ +LL LDY H GI+H D+KP NV+++ + +++ Sbjct: 124 -----EHRGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIK 178 Query: 212 LIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 + D G A +Y + Y + +R ++ PE+L+ + D+WS ++ +I F Sbjct: 179 IADLGNACWY--DEHYTNSIQTREYRSPEVLLGA-PWGCGADIWSTACLIFELITGDFLF 235 Query: 272 FHG-----TSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIR-----KPWHR 321 T + D + +I+++LG + YLL+ R F++ +R K W Sbjct: 236 EPDEGHSYTKDDDHIAQIIELLG--ELPSYLLR-NGKYTRTFFNSRGLLRNISKLKFWPL 292 Query: 322 FINDGNKHLSGNDEII---DLIDNLLRYDHQERLTAKEAMGHPWFAP 365 K+ DE D + +L+ D ++R A + HPW Sbjct: 293 EDVLTEKYKFSKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWLKD 339 >4X7Q-B nrPDB Length = 312 Score = 178 bits (450), Expect = 4e-45, Method: Composition-based stats. Identities = 62/337 (18%), Positives = 117/337 (34%), Gaps = 77/337 (22%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSN 91 D +Y + +G+G + VF G +L ++++ IK++ Sbjct: 25 DREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVI-------------------- 64 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 + D + +L + GH +I L D + LV Sbjct: 65 PRNRVLGWSPLSDSVTCPLEVALLWKVGA------GGGHPGVIRLLDWFETQEGF--MLV 116 Query: 152 FEY----VDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN 207 E D D+ L + R + +++ A+ +CHS G++HRD+K N++ID + Sbjct: 117 LERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRR 176 Query: 208 KKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 +LID+G H + Y +R + PE + ++ + +WS G +L M+ Sbjct: 177 GCAKLIDFGSGALLH-DEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCG 235 Query: 268 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGN 327 PF + ++ +L+ E+ P Sbjct: 236 DIPF--------------------ERDQEILEAELHFPAHV------------------- 256 Query: 328 KHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + + LI L R + +E + PW Sbjct: 257 -----SPDCCALIRRCLAPKPSSRPSLEEILLDPWMQ 288 >4R7H-A nrPDB Length = 343 Score = 178 bits (450), Expect = 5e-45, Method: Composition-based stats. Identities = 56/341 (16%), Positives = 109/341 (31%), Gaps = 90/341 (26%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGV-----KLDSKVKIVIKMLKPV----KKKKIKRE 82 W + + +G G + +V + K D+ +K+ +KMLK +K+ + E Sbjct: 44 KWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSE 103 Query: 83 IKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD 142 +KI++ L H NI++L Sbjct: 104 LKIMSHL--------------------------------------GQHENIVNLLGACTH 125 Query: 143 PISKTPALVFEYVDNVDFRILYPK--------------------------LTDLEIRFYM 176 ++ EY D + L ++ + Sbjct: 126 --GGPVLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFS 183 Query: 177 FELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF- 235 ++ + + + S +HRDV NV++ + ++ D+GLA + Y V+ +R Sbjct: 184 SQVAQGMAFLASKNCIHRDVAARNVLLTN-GHVAKIGDFGLARDIMNDSNYIVKGNARLP 242 Query: 236 --FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDF 293 + PE + D +Y D+WS+G +L + + G + K+VK Sbjct: 243 VKWMAPESIFD-SVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVK------- 294 Query: 294 EKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGND 334 + Y + P+ Y + Q W Sbjct: 295 DGYQMAQPAFAPKNIYSIMQ---ACWALEPTHRPTFQQITS 332 >5H2U-A nrPDB Length = 267 Score = 177 bits (449), Expect = 5e-45, Method: Composition-based stats. Identities = 50/319 (15%), Positives = 116/319 (36%), Gaps = 64/319 (20%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPV---KKKKIKREIKILTDL 89 +++ + K+G G + EVF+G+ D +V++ IK++ ++ ++ EI+ + L Sbjct: 1 MERPREEFTLCRKLGSGYFGEVFEGLWKD-RVQVAIKVISRDNLLHQQMLQSEIQAMKKL 59 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 H +I+ L+ ++ + Sbjct: 60 R---------------------------------------HKHILALYAVV--SVGDPVY 78 Query: 150 LVFEYVDNVDFRILY-----PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID 204 ++ E + L L E+ +++ + + Y S +HRD+ N+++ Sbjct: 79 IITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVG 138 Query: 205 HKNKKLRLIDWGLAEFYHVNMEYNVRVASRF-FKGPELLVDYRMYDYSLDLWSFGTMLAS 263 +N ++ D+GLA ++ + + + PE L Y D+WSFG +L Sbjct: 139 -ENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEAL-SRGHYSTKSDVWSFGILLHE 196 Query: 264 MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFI 323 M + + + G SN + +++ Y + + P + + + W R Sbjct: 197 MFSRGQVPYPGMSNHEAFLRV--------DAGYRMPCPLECP---PSVHKLMLTCWCRDP 245 Query: 324 NDGNKHLSGNDEIIDLIDN 342 + + + + Sbjct: 246 EQRPTFKALRERLSSFTSH 264 >4RC3-A nrPDB Length = 289 Score = 177 bits (448), Expect = 8e-45, Method: Composition-based stats. Identities = 66/337 (19%), Positives = 119/337 (35%), Gaps = 79/337 (23%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 93 Y++ +G G + V+ G+++ + + IK ++ K I +L N Sbjct: 8 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVE-------KDRISDWGELPNGT 60 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 P + K +I L D + P S L+ E Sbjct: 61 RVPMEVVLLKKVSSGFSG---------------------VIRLLDWFERPDSF--VLILE 97 Query: 154 Y----VDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 D DF L + R + +++L+A+ +CH+ G++HRD+K N++ID + Sbjct: 98 RPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE 157 Query: 210 LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 L+LID+G + Y +R + PE + +R + S +WS G +L M+ Sbjct: 158 LKLIDFGSGALLK-DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI 216 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 PF H +++ ++ + Sbjct: 217 PFEHDEE--------------------IIRGQVFFRQRV--------------------- 235 Query: 330 LSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPI 366 + E LI L +R T +E HPW + Sbjct: 236 ---SSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 269 >5TQX-A nrPDB Length = 655 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 68/327 (20%), Positives = 115/327 (35%), Gaps = 69/327 (21%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIK----MLKPVKKKKIKREIKILTDLSNEKVP 95 +E+ ++G G + V + +KI IK L +++ EI+I+ L+ Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLN----- 64 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP---ISKTPALVF 152 HAN++ D+ ++ I P L Sbjct: 65 ----------------------------------HANVVKACDVPEELNILIHDVPLLAM 90 Query: 153 EYVDNVDFRILYPK------LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK 206 EY D R L K L + +I + ++ + Y H I+HRD+KP N+++ Sbjct: 91 EYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDV 150 Query: 207 NKKL--RLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASM 264 K+ ++ID G A+ V + + PE L + + Y ++D WSFGTM+ Sbjct: 151 GGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPE-LFENKPYTATVDYWSFGTMVFEC 209 Query: 265 IFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIN 324 I PF H KI K F + E+ + N Sbjct: 210 IAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCSLIVEPMEN 269 Query: 325 DGNKHLSGNDEIIDLIDNLLRYDHQER 351 + +L +D Q+R Sbjct: 270 W--------------LQLMLNWDPQQR 282 >2VD5-A nrPDB Length = 412 Score = 176 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 71/356 (19%), Positives = 113/356 (31%), Gaps = 97/356 (27%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIK------MLKPVKKKKIKREIKILT 87 D+EI +GRG +SEV + +K MLK + + E +L Sbjct: 57 RLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLV 116 Query: 88 DLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKT 147 + + FQ + Y Sbjct: 117 NGDRRWITQLHFAFQDENY----------------------------------------- 135 Query: 148 PALVFEYVDNVDFRILYPKLTD----LEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI 203 LV EY D L K + RFY+ E++ A+D H +G +HRD+KP N+++ Sbjct: 136 LYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILL 195 Query: 204 DHKNKKLRLIDWGLAEFYHVNMEYN--VRVASRFFKGPELLV------DYRMYDYSLDLW 255 D + +RL D+G + V V + + PE+L Y D W Sbjct: 196 D-RCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWW 254 Query: 256 SFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYI 315 + G M + + PF+ S + KIV Sbjct: 255 ALGVFAYEMFYGQTPFY-ADSTAETYGKIVH----------------------------- 284 Query: 316 RKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERL---TAKEAMGHPWFAPIRE 368 + ++ +E D I LL + RL A + HP+F + Sbjct: 285 ---YKEHLSLPLVDEGVPEEARDFIQRLL-CPPETRLGRGGAGDFRTHPFFFGLDW 336 >3CJF-A nrPDB Length = 309 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 63/346 (18%), Positives = 121/346 (34%), Gaps = 82/346 (23%) Query: 29 TVIDWSTNTKDYEIENKVGRGKYSEVFQG-----VKLDSKVKIVIKMLKPV----KKKKI 79 W + +GRG + +V + K + + +KMLK + + + Sbjct: 18 DASKWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRAL 77 Query: 80 KREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDI 139 E+KIL + + H N+++L Sbjct: 78 MSELKILIHIGH--------------------------------------HLNVVNLLGA 99 Query: 140 IKDPISKTPALVFEYVDNVDFRILYPK---------------LTDLEIRFYMFELLKALD 184 P +V E+ + LT + Y F++ K ++ Sbjct: 100 CTKPGGPLMVIV-EFCKFGNLSTYLRSKRNEFVPYKDLYKDFLTLEHLICYSFQVAKGME 158 Query: 185 YCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPEL 241 + S +HRD+ N+++ KN +++ D+GLA + + +Y + +R + PE Sbjct: 159 FLASRKCIHRDLAARNILLSEKN-VVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPET 217 Query: 242 LVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYE 301 + D R+Y D+WSFG +L + + G VKI + E ++ Sbjct: 218 IFD-RVYTIQSDVWSFGVLLWEIFSLGASPYPG-------VKIDEEFCRRLKEGTRMRAP 269 Query: 302 ITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYD 347 E Y Q + WH + E+++ + NLL+ + Sbjct: 270 DYTTPEMY---QTMLDCWHGEPSQRPTF----SELVEHLGNLLQAN 308 >1AD5-A nrPDB Length = 438 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 45/333 (13%), Positives = 116/333 (34%), Gaps = 81/333 (24%) Query: 17 KQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKP--V 74 + ++ W+ + W + ++E K+G G++ EV+ K+ +K +KP + Sbjct: 165 SSKPQKPWEKDA----WEIPRESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPGSM 219 Query: 75 KKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANII 134 + E ++ L ++K+ + Sbjct: 220 SVEAFLAEANVMKTLQHDKL---------------------------------------V 240 Query: 135 HLFDIIKDPISKTPALVFEYVDNVDFRILYP-----KLTDLEIRFYMFELLKALDYCHSM 189 L ++ + ++ E++ K ++ + ++ + + + Sbjct: 241 KLHAVV---TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQR 297 Query: 190 GIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYR 246 +HRD++ N+++ + ++ D+GLA V ++F + PE + ++ Sbjct: 298 NYIHRDLRAANILVSA-SLVCKIADFGLAR-----------VGAKFPIKWTAPEAI-NFG 344 Query: 247 MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPR 306 + D+WSFG +L ++ + G SN + + + + Y + P Sbjct: 345 SFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALER--------GYRMPRPENCPE 396 Query: 307 EFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDL 339 E Y++ + + W + + D Sbjct: 397 ELYNI---MMRCWKNRPEERPTFEYIQSVLDDF 426 >4E93-A nrPDB Length = 377 Score = 174 bits (441), Expect = 5e-44, Method: Composition-based stats. Identities = 61/320 (19%), Positives = 103/320 (32%), Gaps = 67/320 (20%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIK----MLKPVKKKKIKREIKILT 87 W N +D + ++GRG + EVF G + +K L P K K +E +IL Sbjct: 108 KWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILK 167 Query: 88 DLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKT 147 S H NI+ L + + Sbjct: 168 QYS---------------------------------------HPNIVRLIGVCTQ--KQP 186 Query: 148 PALVFEYVDNVDF----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI 203 +V E V DF R +L + + + ++Y S +HRD+ N ++ Sbjct: 187 IYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLV 246 Query: 204 DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF----FKGPELLVDYRMYDYSLDLWSFGT 259 KN L++ D+G++ + Y R + PE L +Y Y D+WSFG Sbjct: 247 TEKN-VLKISDFGMSRE-EADGVYAASGGLRQVPVKWTAPEAL-NYGRYSSESDVWSFGI 303 Query: 260 MLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPW 319 +L + SN + K L P + + + + W Sbjct: 304 LLWETFSLGASPYPNLSNQQTREFVEK--------GGRLPCPELCPDAVF---RLMEQCW 352 Query: 320 HRFINDGNKHLSGNDEIIDL 339 + E+ + Sbjct: 353 AYEPGQRPSFSTIYQELQSI 372 >2XNP-A nrPDB Length = 279 Score = 174 bits (441), Expect = 6e-44, Method: Composition-based stats. Identities = 66/344 (19%), Positives = 116/344 (33%), Gaps = 96/344 (27%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK-----PVKKKKIKREIKILTDLSNE 92 +DYE+ +G G Y + + +V K L +K+ + E+ +L +L Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELK-- 63 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF 152 H NI+ +D I D + T +V Sbjct: 64 -------------------------------------HPNIVRYYDRIIDRTNTTLYIVM 86 Query: 153 EYVDNVDFRILYPK-------LTDLEIRFYMFELLKALDYCHSMG-----IMHRDVKPHN 200 EY + D + K L + + M +L AL CH ++HRD+KP N Sbjct: 87 EYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDGGHTVLHRDLKPAN 146 Query: 201 VMIDHKNKKLRLIDWGLAEFYHVNMEY-NVRVASRFFKGPELLVDYRMYDYSLDLWSFGT 259 V +D K + ++L D+GLA + + + V + ++ PE + + Y+ D+WS G Sbjct: 147 VFLDGK-QNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQM-NRMSYNEKSDIWSLGC 204 Query: 260 MLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPW 319 +L + PF Q Sbjct: 205 LLYELCALMPPF-------------------------------------TAFSQKELAGK 227 Query: 320 HRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 R +DE+ ++I +L R + +E + +P Sbjct: 228 IREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENPLI 271 >6DBN-A nrPDB Length = 316 Score = 174 bits (440), Expect = 7e-44, Method: Composition-based stats. Identities = 61/366 (16%), Positives = 129/366 (35%), Gaps = 81/366 (22%) Query: 6 WSEARVYTNINKQRTE--EYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKL--- 60 S R + +Q + V + + +G G + +V Sbjct: 1 GSIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEG 60 Query: 61 -DSKVKIVIKMLKPVK----KKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVL 115 ++ ++ +K LKP +K+EI+IL +L Sbjct: 61 DNTGEQVAVKSLKPESGGNHIADLKKEIEILRNL-------------------------- 94 Query: 116 KFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK----LTDLE 171 H NI+ I + L+ E++ + + PK + + Sbjct: 95 -------------YHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQ 141 Query: 172 IRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNV-- 229 Y ++ K +DY S +HRD+ NV+++ ++ ++++ D+GL + + EY Sbjct: 142 QLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEH-QVKIGDFGLTKAIETDKEYYTVK 200 Query: 230 --RVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKV 287 R + F+ PE L+ + Y + D+WSFG L ++ + S++ + +K+ Sbjct: 201 DDRDSPVFWYAPECLMQSKFY-IASDVWSFGVTLHELLT------YCDSDSSPMALFLKM 253 Query: 288 LGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYD 347 +G + + + + TL + + DE+ L+ + Sbjct: 254 IGPTHGQMTVTRLVNTL----------------KEGKRLPCPPNCPDEVYQLMRKCWEFQ 297 Query: 348 HQERLT 353 R + Sbjct: 298 PSNRTS 303 >4OTD-A nrPDB Length = 341 Score = 174 bits (440), Expect = 8e-44, Method: Composition-based stats. Identities = 62/340 (18%), Positives = 114/340 (33%), Gaps = 80/340 (23%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 +D++ +GRG + +V S IK LK Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGD---------------------- 49 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 + + L + + GH +++LF + P + V EY Sbjct: 50 --------IVARDEVESLMCEKRILAAVTSAGHPFLVNLFGCFQTP--EHVCFVMEYSAG 99 Query: 158 VDFRILYPK--LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDW 215 D + ++ FY ++ L + H I++RD+K N+++D + +++ D+ Sbjct: 100 GDLMLHIHSDVFSEPRAIFYSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGY-VKIADF 158 Query: 216 GLAEF-YHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHG 274 GL + + + F PE+L D Y ++D W G +L M+ PF G Sbjct: 159 GLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTS-YTRAVDWWGLGVLLYEMLVGESPF-PG 216 Query: 275 TSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGND 334 + IV E+ PR + Sbjct: 217 DDEEEVFDSIVN-------------DEVRYPRFL------------------------SA 239 Query: 335 EIIDLIDNLLRYDHQERL-----TAKEAMGHPWFAPIREQ 369 E I ++ LLR + + RL A++ P+F + + Sbjct: 240 EAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWE 279 >3VN9-A nrPDB Length = 340 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 56/337 (16%), Positives = 117/337 (34%), Gaps = 70/337 (20%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSN 91 ++ D E ++GRG Y V + + S + +K ++ +E K L + Sbjct: 45 NFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNS---QEQKRLLMDLD 101 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 + PF Y +E + + + +I Sbjct: 102 ISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVI----------------- 144 Query: 152 FEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSM-GIMHRDVKPHNVMIDHKNKKL 210 + + + ++KAL++ HS ++HRDVKP NV+I+ ++ Sbjct: 145 ----------DKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALG-QV 193 Query: 211 RLIDWGLAEFYHVNMEYNVRVASRFFKGPELL---VDYRMYDYSLDLWSFGTMLASMIFK 267 ++ D+G++ + ++ + + + PE + ++ + Y D+WS G + + Sbjct: 194 KMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAIL 253 Query: 268 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGN 327 R P+ + QL ++V+ + Sbjct: 254 RFPYDSWGTPFQQLKQVVE-----------------------------------EPSPQL 278 Query: 328 KHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + E +D L+ + +ER T E M HP+F Sbjct: 279 PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 315 >3M42-A nrPDB Length = 299 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 68/337 (20%), Positives = 115/337 (34%), Gaps = 102/337 (30%) Query: 37 TKDYEIE-NKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVP 95 DY++ +G G +V Q ++ K +KML+ K +RE+++ Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ--DCPKARREVEL---------- 63 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD--PISKTPALVFE 153 + +I+ + D+ ++ K +V E Sbjct: 64 ----------------------------HWRASQCPHIVRIVDVYENLYAGRKCLLIVME 95 Query: 154 YVDNVDFRILYP-----KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK-- 206 +D + T+ E M + +A+ Y HS+ I HRDVKP N++ K Sbjct: 96 CLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRP 155 Query: 207 NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 N L+L D+G A+ YD S D+WS G ++ ++ Sbjct: 156 NAILKLTDFGFAKET----------------------TGEKYDKSCDMWSLGVIMYILLC 193 Query: 267 KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG 326 PF+ M IR + F N Sbjct: 194 GYPPFYSNHG----------------------------LAISPGMKTRIRMGQYEFPNPE 225 Query: 327 NKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 363 + ++E+ LI NLL+ + +R+T E M HPW Sbjct: 226 WSEV--SEEVKMLIRNLLKTEPTQRMTITEFMNHPWI 260 >2PSQ-A nrPDB Length = 370 Score = 173 bits (438), Expect = 1e-43, Method: Composition-based stats. Identities = 64/355 (18%), Positives = 119/355 (33%), Gaps = 84/355 (23%) Query: 21 EEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQ----GVKLDS---KVKIVIKMLKP 73 EY E+ W + +G G + +V G+ D V + +KMLK Sbjct: 66 SEYELPED--PKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKD 123 Query: 74 VKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANI 133 +K D+ + + H NI Sbjct: 124 DATEK----------------------------------DLSDLVSEMEMMKMIGKHKNI 149 Query: 134 IHLFDIIKDPISKTPALVFEYVDNVDFRILY-------------------PKLTDLEIRF 174 I+L ++ EY + R ++T ++ Sbjct: 150 INLLGACTQ--DGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVS 207 Query: 175 YMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASR 234 ++L + ++Y S +HRD+ NV++ +N +++ D+GLA + Y R Sbjct: 208 CTYQLARGMEYLASQKCIHRDLAARNVLVT-ENNVMKIADFGLARDINNIDYYKKTTNGR 266 Query: 235 F---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTS 291 + PE L D R+Y + D+WSFG ++ + + G ++L K++K Sbjct: 267 LPVKWMAPEALFD-RVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLLK----- 319 Query: 292 DFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRY 346 E + + E Y M +R WH + ++ +D +L Sbjct: 320 --EGHRMDKPANCTNELYMM---MRDCWHAVPSQRPTFKQLVED----LDRILTL 365 >1ZXE-A nrPDB Length = 303 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 68/323 (21%), Positives = 125/323 (38%), Gaps = 55/323 (17%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKK--KIKREIKILTDLSNEKVP 95 D+E +G+G + +V + IK ++ ++K I E+ +L L+++ V Sbjct: 6 SDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQYVV 65 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 + + + + V K T + EY Sbjct: 66 RYYAAWLERRNFVKPMTAVKK----------------------------KSTLFIQMEYC 97 Query: 156 DNVDFRILYPKLTDLEIR----FYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 +N L + R ++L+AL Y HS GI+HR++KP N+ ID +++ ++ Sbjct: 98 ENRTLYDLIHSENLNQQRDEYWRLFRQILEALSYIHSQGIIHRNLKPMNIFID-ESRNVK 156 Query: 212 LIDWGLAEFYH---------------VNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWS 256 + D+GLA+ H + + + + E+L Y+ +D++S Sbjct: 157 IGDFGLAKNVHRSLDILKLDSQNLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYS 216 Query: 257 FGTMLASMIFKREPFFHGTSNTDQLVKI--VKVLGTSDFEKYLLKYEITLPREFYDMDQY 314 G + MI+ PF G + L K+ V + DF+ +K E + R D D Sbjct: 217 LGIIFFEMIY---PFSTGMERVNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPN 273 Query: 315 IRKPWHRFINDGNKHLSGNDEII 337 R +N G + DE+I Sbjct: 274 KRPGARTLLNSGWLPVKHQDEVI 296 >3ALO-A nrPDB Length = 327 Score = 172 bits (435), Expect = 2e-43, Method: Composition-based stats. Identities = 65/341 (19%), Positives = 120/341 (35%), Gaps = 66/341 (19%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNE 92 W +D + ++GRG Y V + V S + +K ++ + K + ++L DL Sbjct: 17 WDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDE--KEQKQLLMDLD-V 73 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF 152 + + P+ Y +E + D K V Sbjct: 74 VMRSSDCPYIVQFYGALFREGDCWICMELMSTSF---------------DKFYKYVYSVL 118 Query: 153 EYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSM-GIMHRDVKPHNVMIDHKNKKLR 211 + V + + + +KAL++ I+HRD+KP N+++D ++ ++ Sbjct: 119 DDV-----------IPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLD-RSGNIK 166 Query: 212 LIDWGLAEFYHVNMEYNVRVASRFFKGPELL---VDYRMYDYSLDLWSFGTMLASMIFKR 268 L D+G++ ++ R + PE + + YD D+WS G L + R Sbjct: 167 LCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGR 226 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 P+ S DQL ++VK D Q F Sbjct: 227 FPYPKWNSVFDQLTQVVKG----------------------DPPQLSNSEEREF------ 258 Query: 329 HLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 + I+ ++ L D +R KE + HP+ E+ Sbjct: 259 ----SPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEER 295 >4E20-A nrPDB Length = 290 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 57/318 (17%), Positives = 116/318 (36%), Gaps = 70/318 (22%) Query: 40 YEIENKVGRGKYSEV----FQGVKLDSKVKIVIKMLK----PVKKKKIKREIKILTDLSN 91 + +G G + +V + + + +K LK P + +REI+IL L Sbjct: 10 LKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTL-- 67 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H +I+ +D K+ LV Sbjct: 68 -------------------------------------YHEHIVKYKGCCEDQGEKSVQLV 90 Query: 152 FEYVDNVDFRILYPK--LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 EYV R P+ + ++ + ++ + + Y H+ +HR + NV++D+ ++ Sbjct: 91 MEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEGMAYLHAQHYIHRALAARNVLLDN-DRL 149 Query: 210 LRLIDWGLAEFYHVNMEYNVRV----ASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 +++ D+GLA+ EY + F+ PE L + + Y Y+ D+WSFG L ++ Sbjct: 150 VKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFY-YASDVWSFGVTLYELL 208 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFY---------DMDQYIR 316 + SN K +++G + + +L+ L R ++ ++ Sbjct: 209 T------YCDSNQSPHTKFTELIGHTQGQMTVLRLTELLERGERLPRPDRCPCEIYHLMK 262 Query: 317 KPWHRFINDGNKHLSGND 334 W + + Sbjct: 263 NCWETEASFRPTFQNLVP 280 >3FME-A nrPDB Length = 290 Score = 171 bits (434), Expect = 3e-43, Method: Composition-based stats. Identities = 56/337 (16%), Positives = 116/337 (34%), Gaps = 70/337 (20%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSN 91 D E ++GRG Y V + + S + +K ++ +E K L + Sbjct: 1 SMEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNS---QEQKRLLMDLD 57 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 + PF Y +E + + + +I Sbjct: 58 ISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVI----------------- 100 Query: 152 FEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSM-GIMHRDVKPHNVMIDHKNKKL 210 + + + ++KAL++ HS ++HRDVKP NV+I+ ++ Sbjct: 101 ----------DKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALG-QV 149 Query: 211 RLIDWGLAEFYHVNMEYNVRVASRFFKGPELL---VDYRMYDYSLDLWSFGTMLASMIFK 267 ++ D+G++ + ++ ++ + + PE + ++ + Y D+WS G + + Sbjct: 150 KMCDFGISGYLVDDVAKDIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAIL 209 Query: 268 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGN 327 R P+ + QL ++V+ + Sbjct: 210 RFPYDSWGTPFQQLKQVVE-----------------------------------EPSPQL 234 Query: 328 KHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 + E +D L+ + +ER T E M HP+F Sbjct: 235 PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFT 271 >3TT0-A nrPDB Length = 382 Score = 171 bits (433), Expect = 4e-43, Method: Composition-based stats. Identities = 63/345 (18%), Positives = 115/345 (33%), Gaps = 80/345 (23%) Query: 21 EEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQG------VKLDSKV-KIVIKMLKP 73 EY E+ W + +G G + +V ++V K+ +KMLK Sbjct: 54 SEYELPED--PRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKS 111 Query: 74 VKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANI 133 +K D+ I + H NI Sbjct: 112 DATEK----------------------------------DLSDLISEMEMMKMIGKHKNI 137 Query: 134 IHLFDIIKDPISKTPALVFEYVDNVDFRILYP-------------------KLTDLEIRF 174 I+L ++ EY + R +L+ ++ Sbjct: 138 INLLGACTQ--DGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQLSSKDLVS 195 Query: 175 YMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASR 234 +++ + ++Y S +HRD+ NV++ N +++ D+GLA H Y R Sbjct: 196 CAYQVARGMEYLASKKCIHRDLAARNVLVTEDN-VMKIADFGLARDIHHIDYYKKTTNGR 254 Query: 235 F---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTS 291 + PE L D R+Y + D+WSFG +L + + G ++L K++K Sbjct: 255 LPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLLK----- 307 Query: 292 DFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEI 336 E + + E Y M +R WH + +++ Sbjct: 308 --EGHRMDKPSNCTNELYMM---MRDCWHAVPSQRPTFKQLVEDL 347 >3PPZ-A nrPDB Length = 309 Score = 171 bits (432), Expect = 6e-43, Method: Composition-based stats. Identities = 61/345 (17%), Positives = 115/345 (33%), Gaps = 76/345 (22%) Query: 23 YWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVK-----KK 77 Y+ D D I+ K+G G + V + + +K+L Sbjct: 22 YFQGAMDGDDMDIPWCDLNIKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQDFHAERVN 79 Query: 78 KIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLF 137 + RE+ I+ L H NI+ Sbjct: 80 EFLREVAIMKRLR---------------------------------------HPNIVLFM 100 Query: 138 DIIKDPISKTPALVFEYVDNVDFRILYPK------LTDLEIRFYMFELLKALDYCHSMG- 190 + P + ++V EY+ L K L + +++ K ++Y H+ Sbjct: 101 GAVTQPPN--LSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNYLHNRNP 158 Query: 191 -IMHRDVKPHNVMIDHKNKKLRLIDWGLAEF-YHVNMEYNVRVASRFFKGPELLVDYRMY 248 I+HRD+K N+++D K +++ D+GL+ + + + PE+L D Sbjct: 159 PIVHRDLKSPNLLVDKK-YTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVLRDEPS- 216 Query: 249 DYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREF 308 + D++SFG +L + ++P+ G N Q+V V + K Sbjct: 217 NEKSDVYSFGVILWELATLQQPW--GNLNPAQVVAAV---------GFKCKRLEIPRNLN 265 Query: 309 YDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLR--YDHQER 351 + I W + I+DL+ L++ R Sbjct: 266 PQVAAIIEGCWTNEPWKRPSFAT----IMDLLRPLIKSAVPPPNR 306 >5A46-A nrPDB Length = 386 Score = 170 bits (431), Expect = 8e-43, Method: Composition-based stats. Identities = 63/345 (18%), Positives = 115/345 (33%), Gaps = 80/345 (23%) Query: 21 EEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQG------VKLDSKV-KIVIKMLKP 73 EY E+ W + +G G + +V ++V K+ +KMLK Sbjct: 25 SEYELPED--PRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKS 82 Query: 74 VKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANI 133 +K D+ I + H NI Sbjct: 83 DATEK----------------------------------DLSDLISEMEMMKMIGKHKNI 108 Query: 134 IHLFDIIKDPISKTPALVFEYVDNVDFRILYP-------------------KLTDLEIRF 174 I+L ++ EY + R +L+ ++ Sbjct: 109 INLLGACTQ--DGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVS 166 Query: 175 YMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASR 234 +++ + ++Y S +HRD+ NV++ N +++ D+GLA H Y R Sbjct: 167 CAYQVARGMEYLASKKCIHRDLAARNVLVTEDN-VMKIADFGLARDIHHIDYYKKTTNGR 225 Query: 235 F---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTS 291 + PE L D R+Y + D+WSFG +L + + G ++L K++K Sbjct: 226 LPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLLK----- 278 Query: 292 DFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEI 336 E + + E Y M +R WH + +++ Sbjct: 279 --EGHRMDKPSNCTNELYMM---MRDCWHAVPSQRPTFKQLVEDL 318 >4RT7-A nrPDB Length = 415 Score = 170 bits (431), Expect = 8e-43, Method: Composition-based stats. Identities = 60/368 (16%), Positives = 130/368 (35%), Gaps = 58/368 (15%) Query: 22 EYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGV-----KLDSKVKIVIKMLKPV-- 74 ++ +YE + W ++ E +G G + +V K +++ +KMLK Sbjct: 50 DFREYEYD-LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKAD 108 Query: 75 --KKKKIKREIKILTDLSNEKVPPT----------------TLPFQKDQYYTNQKEDVLK 116 +++ + E+K++T L + + + Y K + Sbjct: 109 SSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFH 168 Query: 117 FIRPYIFDQPHNG-------HAN-----------------IIHLFDIIKDPISKTPALVF 152 IF + + H N I L + + + Sbjct: 169 RTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHG---NSFHSEDEIEY 225 Query: 153 EYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRL 212 E ++ LT ++ + +++ K +++ +HRD+ NV++ H K +++ Sbjct: 226 ENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH-GKVVKI 284 Query: 213 IDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 D+GLA + Y VR +R + PE L + +Y D+WS+G +L + Sbjct: 285 CDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFE-GIYTIKSDVWSYGILLWEIFSLGV 343 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 + G K+++ D Y + + + + D R + + Sbjct: 344 NPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQ 403 Query: 330 LSGNDEII 337 L+ +E + Sbjct: 404 LADAEEAM 411 >4UY9-A nrPDB Length = 323 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 52/315 (16%), Positives = 110/315 (34%), Gaps = 61/315 (19%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 93 + + +E +G G + +V++ + ++ +K + + I + I+ Sbjct: 5 EIDFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIE--------- 53 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 +R H NII L + + LV E Sbjct: 54 -----------------------NVRQEAKLFAMLKHPNIIALRGVCLKEPNLC--LVME 88 Query: 154 YVDNVDFRILY--PKLTDLEIRFYMFELLKALDYCHSMG---IMHRDVKPHNVMI----- 203 + + ++ + + ++ + ++Y H I+HRD+K N++I Sbjct: 89 FARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVE 148 Query: 204 --DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTML 261 D NK L++ D+GLA +H + + + + PE++ M+ D+WS+G +L Sbjct: 149 NGDLSNKILKITDFGLAREWHRTTKMSA-AGTYAWMAPEVIR-ASMFSKGSDVWSYGVLL 206 Query: 262 ASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 ++ PF G + K L T P F + + W+ Sbjct: 207 WELLTGEVPF-RGIDGLAVAYGVA-------MNKLALPIPSTCPEPF---AKLMEDCWNP 255 Query: 322 FINDGNKHLSGNDEI 336 + + D++ Sbjct: 256 DPHSRPSFTNILDQL 270 >3DTC-A nrPDB Length = 271 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 52/315 (16%), Positives = 110/315 (34%), Gaps = 61/315 (19%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 93 + + +E +G G + +V++ + ++ +K + + I + I+ Sbjct: 3 EIDFAELTLEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTIE--------- 51 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 +R H NII L + + LV E Sbjct: 52 -----------------------NVRQEAKLFAMLKHPNIIALRGVCLKEPNLC--LVME 86 Query: 154 YVDNVDFRILY--PKLTDLEIRFYMFELLKALDYCHSMG---IMHRDVKPHNVMI----- 203 + + ++ + + ++ + ++Y H I+HRD+K N++I Sbjct: 87 FARGGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVE 146 Query: 204 --DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTML 261 D NK L++ D+GLA +H + + + + PE++ M+ D+WS+G +L Sbjct: 147 NGDLSNKILKITDFGLAREWHRTTKMSA-AGAYAWMAPEVIR-ASMFSKGSDVWSYGVLL 204 Query: 262 ASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 ++ PF G + K L T P F + + W+ Sbjct: 205 WELLTGEVPF-RGIDGLAVAYGVA-------MNKLALPIPSTCPEPF---AKLMEDCWNP 253 Query: 322 FINDGNKHLSGNDEI 336 + + D++ Sbjct: 254 DPHSRPSFTNILDQL 268 >4APC-A nrPDB Length = 350 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 55/348 (15%), Positives = 127/348 (36%), Gaps = 94/348 (27%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIK-----MLKPVKKKKIKREIKILTDLS 90 + + Y K+G G + + + + VIK + ++++ +RE+ +L ++ Sbjct: 22 SMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMK 81 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 H NI+ + ++ + + + Sbjct: 82 ---------------------------------------HPNIVQYRESFEE--NGSLYI 100 Query: 151 VFEYVDNVDF--RILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 V +Y + D RI K + +I + ++ AL + H I+HRD+K N+ + Sbjct: 101 VMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLT- 159 Query: 206 KNKKLRLIDWGLAEFYHVNMEYNVRV-ASRFFKGPELLVDYRMYDYSLDLWSFGTMLASM 264 K+ ++L D+G+A + +E + ++ PE + + + Y+ D+W+ G +L + Sbjct: 160 KDGTVQLGDFGIARVLNSTVELARACIGTPYYLSPE-ICENKPYNNKSDIWALGCVLYEL 218 Query: 265 IFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIN 324 + F G S + ++KI+ Y Sbjct: 219 CTLKHAFEAG-SMKNLVLKIISGSFPPVSLHY---------------------------- 249 Query: 325 DGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK 372 + ++ L+ L + + ++R + + + A ++IEK Sbjct: 250 --------SYDLRSLVSQLFKRNPRDRPSVNSILEKGFIA---KRIEK 286 >3GQL-A nrPDB Length = 326 Score = 169 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 63/345 (18%), Positives = 115/345 (33%), Gaps = 80/345 (23%) Query: 21 EEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQG------VKLDSKV-KIVIKMLKP 73 EY E+ W + +G G + +V ++V K+ +KMLK Sbjct: 13 SEYELPED--PRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKS 70 Query: 74 VKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANI 133 +K D+ I + H NI Sbjct: 71 DATEK----------------------------------DLSDLISEMEMMKMIGKHKNI 96 Query: 134 IHLFDIIKDPISKTPALVFEYVDNVDFRILYP-------------------KLTDLEIRF 174 I+L ++ EY + R +L+ ++ Sbjct: 97 INLLGACTQ--DGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVS 154 Query: 175 YMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASR 234 +++ + ++Y S +HRD+ NV++ N +++ D+GLA H Y R Sbjct: 155 CAYQVARGMEYLASKKCIHRDLAARNVLVTEDN-VMKIADFGLARDIHHIDYYKKTTNGR 213 Query: 235 F---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTS 291 + PE L D R+Y + D+WSFG +L + + G ++L K++K Sbjct: 214 LPVKWMAPEALFD-RIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLLK----- 266 Query: 292 DFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEI 336 E + + E Y M +R WH + +++ Sbjct: 267 --EGHRMDKPSNCTNELYMM---MRDCWHAVPSQRPTFKQLVEDL 306 >5EG3-A nrPDB Length = 334 Score = 168 bits (425), Expect = 4e-42, Method: Composition-based stats. Identities = 56/338 (16%), Positives = 115/338 (34%), Gaps = 68/338 (20%) Query: 31 IDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLS 90 W + +G G + +V + + K K+ + +K+L D Sbjct: 28 PKWEFPRDKLTLGKPLGEGAFGQVVMAE--------AVGIDKDKPKEAVTVAVKMLKD-- 77 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 ++D+ + + H NII+L + Sbjct: 78 -----------------DATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQ--DGPLYV 118 Query: 151 VFEYVDNVDFRILY-------------------PKLTDLEIRFYMFELLKALDYCHSMGI 191 + Y + R ++T ++ ++L + ++Y S Sbjct: 119 IVAYASKGNLREYLRARRPPGMELSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKC 178 Query: 192 MHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMY 248 +HRD+ NV++ +N +++ D+GLA + + R + PE L D R+Y Sbjct: 179 IHRDLAARNVLVT-ENNVMKIADFGLARDINNIDFFKETTNGRLPVKWMAPEALFD-RVY 236 Query: 249 DYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREF 308 + D+WSFG ++ + + G ++L K++K E + + E Sbjct: 237 THQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLLK-------EGHRMDKPANCTNEL 288 Query: 309 YDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRY 346 Y M +R WH + ++ +D +L Sbjct: 289 YMM---MRDCWHAVPSQRPTFKQLVED----LDRILTL 319 >4TNB-A nrPDB Length = 590 Score = 168 bits (425), Expect = 4e-42, Method: Composition-based stats. Identities = 72/362 (19%), Positives = 117/362 (32%), Gaps = 89/362 (24%) Query: 20 TEEYWD--YENTVIDWS------TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML 71 EY D + + + W + +G+G + EV + K L Sbjct: 158 FHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRL 217 Query: 72 KPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHA 131 + + KK K E L + + + F + Y + +D L Sbjct: 218 EKKRIKKRKGESMALNE--KQILEKVNSQFVVNLAYAYETKDAL---------------- 259 Query: 132 NIIHLFDIIKDPISKTPALVFEYVDNVDFRILY-----PKLTDLEIRFYMFELLKALDYC 186 LV ++ D + P + FY E+L L+ Sbjct: 260 -----------------CLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYR 246 H ++RD+KP N+++D +R+ D GLA RV + + PE+L + R Sbjct: 303 HHENTVYRDLKPENILLDDYG-HIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQR 361 Query: 247 MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPR 306 Y S D W G ++ MI + PF K +K E R Sbjct: 362 -YGLSPDYWGLGCLIYEMIEGQSPF--------------------RGRKEKVKREEVDRR 400 Query: 307 EFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLT-----AKEAMGHP 361 + Y K ++E + LL D ++RL A E HP Sbjct: 401 VLETEEVYSHK--------------FSEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHP 446 Query: 362 WF 363 +F Sbjct: 447 FF 448 >6BXI-A nrPDB Length = 333 Score = 167 bits (424), Expect = 4e-42, Method: Composition-based stats. Identities = 58/296 (19%), Positives = 111/296 (37%), Gaps = 77/296 (26%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 +D+E +GRG + EV K D+ +K+L+ K +++E + + + Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILR--KADMLEKE-----QVGHIRAERD 58 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 L + ++ +F +D ++ L+ E++ Sbjct: 59 ILVEADSLW--------------------------VVKMFYSFQDKLN--LYLIMEFLPG 90 Query: 158 VDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLID 214 D L K LT+ E +FY+ E + A+D H +G +HRD+KP N+++D K ++L D Sbjct: 91 GDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKG-HVKLSD 149 Query: 215 WGLAEFY-----------------------HVNMEYNV-------------RVASRFFKG 238 +GL ++N + V + + Sbjct: 150 FGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIA 209 Query: 239 PELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFE 294 PE+ + Y+ D WS G ++ M+ PF + + K++ T F Sbjct: 210 PEVFMQT-GYNKLCDWWSLGVIMYEMLIGYPPF-CSETPQETYKKVMNWKETLTFP 263 >4CRS-A nrPDB Length = 341 Score = 167 bits (424), Expect = 5e-42, Method: Composition-based stats. Identities = 61/345 (17%), Positives = 111/345 (32%), Gaps = 80/345 (23%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNE 92 + N +D+ + RG + +V ++ IK LK Sbjct: 7 FQFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGD----------------- 49 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF 152 + D L + H +++LF + V Sbjct: 50 -------------IVARDEVDSLMCEKRIFETVNSVRHPFLVNLFACF--QTKEHVCFVM 94 Query: 153 EYVDNVDFRILYPK--LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 EY D + ++ FY ++ L Y H I++RD+K N+++D + + Sbjct: 95 EYAAGGDLMMHIHTDVFSEPRAVFYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGF-V 153 Query: 211 RLIDWGLAEF-YHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 ++ D+GL + + + F PE+L + Y ++D W G ++ M+ Sbjct: 154 KIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETS-YTRAVDWWGLGVLIYEMLVGES 212 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 PF G + IV E+ PR Sbjct: 213 PF-PGDDEEEVFDSIVN-------------DEVRYPRFL--------------------- 237 Query: 330 LSGNDEIIDLIDNLLRYDHQERL-----TAKEAMGHPWFAPIREQ 369 + E I ++ LLR + + RL A++ HP+F I Sbjct: 238 ---STEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWS 279 >5KKR-C nrPDB Length = 395 Score = 167 bits (424), Expect = 5e-42, Method: Composition-based stats. Identities = 63/351 (17%), Positives = 121/351 (34%), Gaps = 60/351 (17%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML----KPVKKKKIKREIKILTDL 89 D+E +++G G VF+ S + + K++ KP + +I RE+++L + Sbjct: 64 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC 123 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 ++ I+ + + Sbjct: 124 NS---------------------------------------PYIVGFYGAFYSDGE--IS 142 Query: 150 LVFEYVDNVDFRILYP---KLTDLEIRFYMFELLKALDYC-HSMGIMHRDVKPHNVMIDH 205 + E++D + ++ + + ++K L Y IMHRDVKP N++++ Sbjct: 143 ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNS 202 Query: 206 KNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 + +++L D+G++ ++ N V +R + PE L Y D+WS G L M Sbjct: 203 RG-EIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGT-HYSVQSDIWSMGLSLVEMA 259 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF--- 322 R P + +L+ +V G + E P Y MD Sbjct: 260 VGRYPIPPPDAKELELMFGCQVEGDA-AETPPRPRTPGRPLSSYGMDSRPPMAIFELLDY 318 Query: 323 ----INDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 + E D ++ L + ER K+ M H + + Sbjct: 319 IVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAE 369 >3DLS-A nrPDB Length = 335 Score = 167 bits (424), Expect = 5e-42, Method: Composition-based stats. Identities = 57/291 (19%), Positives = 114/291 (39%), Gaps = 36/291 (12%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPP 96 ++ Y + +G G + V+ V + ++V+K +K K+L D Sbjct: 23 SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKE---------KVLEDC------- 66 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE--- 153 ++ L + I HANII + DI ++ LV E Sbjct: 67 ------------WIEDPKLGKVTLEIAILSRVEHANIIKVLDIFENQ--GFFQLVMEKHG 112 Query: 154 -YVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRL 212 +D F +P+L + + +L+ A+ Y I+HRD+K N++I ++ ++L Sbjct: 113 SGLDLFAFIDRHPRLDEPLASYIFRQLVSAVGYLRLKDIIHRDIKDENIVI-AEDFTIKL 171 Query: 213 IDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFF 272 ID+G A + + + + PE+L+ L++WS G L +++F+ PF Sbjct: 172 IDFGSAAYLERGKLFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFC 231 Query: 273 HGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFI 323 + + L + + + +P +++ + PW Sbjct: 232 ELEETVEAAIH-PPYLVSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQP 281 >4K33-A nrPDB Length = 325 Score = 167 bits (422), Expect = 9e-42, Method: Composition-based stats. Identities = 61/345 (17%), Positives = 115/345 (33%), Gaps = 82/345 (23%) Query: 31 IDWSTNTKDYEIENKVGRGKYSEVFQ----GVKLDSKVK---IVIKMLKPVKKKKIKREI 83 W + + +G G + +V G+ D K + +KMLK K Sbjct: 29 PKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDK----- 83 Query: 84 KILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP 143 D+ + + H NII+L Sbjct: 84 -----------------------------DLSDLVSEMEMMKMIGKHKNIINLLGACTQ- 113 Query: 144 ISKTPALVFEYVDNVDFRILY-------------------PKLTDLEIRFYMFELLKALD 184 ++ EY + R +LT ++ +++ + ++ Sbjct: 114 -GGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQLTFKDLVSCAYQVARGME 172 Query: 185 YCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPEL 241 Y S +HRD+ NV++ N +++ D+GLA H Y R + PE Sbjct: 173 YLASQKCIHRDLAARNVLVTEDN-VMKIADFGLARDVHNLDYYKETTNGRLPVKWMAPEA 231 Query: 242 LVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYE 301 L D R+Y + D+WSFG +L + + G ++L K++K E + + Sbjct: 232 LFD-RVYTHQSDVWSFGVLLWEIFTLGGSPYPGI-PVEELFKLLK-------EGHRMDKP 282 Query: 302 ITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRY 346 + Y + +R+ WH + ++ +D +L Sbjct: 283 ANCTHDLYMI---MRECWHAAPSQRPTFKQLVED----LDRVLTV 320 >3HNG-A nrPDB Length = 360 Score = 167 bits (422), Expect = 9e-42, Method: Composition-based stats. Identities = 64/367 (17%), Positives = 134/367 (36%), Gaps = 79/367 (21%) Query: 29 TVIDWSTNTKDYEIENKVGRGKYSEVFQG-----VKLDSKVKIVIKMLK----PVKKKKI 79 W + ++ +GRG + +V Q K + + +KMLK + K + Sbjct: 18 DASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKAL 77 Query: 80 KREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDI 139 E+KILT + + L K P + + + N+ + Sbjct: 78 MTELKILTHIGHHLNVVNLLGACT------------KQGGPLMVIVEYCKYGNLSNYLKS 125 Query: 140 IKD--PISKTPALVFE----YVDNVDFRILYPKL-------------------------- 167 +D ++K AL E ++ + P+L Sbjct: 126 KRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEE 185 Query: 168 -----------TDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWG 216 T ++ Y F++ + +++ S +HRD+ N+++ +N +++ D+G Sbjct: 186 EDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLS-ENNVVKICDFG 244 Query: 217 LAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFH 273 LA + N +Y + +R + PE + D ++Y D+WS+G +L + + Sbjct: 245 LARDIYKNPDYVRKGDTRLPLKWMAPESIFD-KIYSTKSDVWSYGVLLWEIFSLGGSPYP 303 Query: 274 GTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGN 333 G V++ + + E ++ E Y Q + WHR + + Sbjct: 304 G-------VQMDEDFCSRLREGMRMRAPEYSTPEIY---QIMLDCWHRDPKERPRFAELV 353 Query: 334 DEIIDLI 340 +++ DL+ Sbjct: 354 EKLGDLL 360 >3EQC-A nrPDB Length = 360 Score = 166 bits (420), Expect = 1e-41, Method: Composition-based stats. Identities = 59/350 (16%), Positives = 121/350 (34%), Gaps = 58/350 (16%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML----KPVKKKKIKREIKILTDL 89 D+E +++G G VF+ S + + K++ KP + +I RE+++L + Sbjct: 29 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC 88 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 ++ I+ + + Sbjct: 89 NS---------------------------------------PYIVGFYGAFYSDGE--IS 107 Query: 150 LVFEYVDNVDFRILYP---KLTDLEIRFYMFELLKALDYC-HSMGIMHRDVKPHNVMIDH 205 + E++D + ++ + + ++K L Y IMHRDVKP N++++ Sbjct: 108 ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNS 167 Query: 206 KNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 + +++L D+G++ ++ N V +R + PE L Y D+WS G L M Sbjct: 168 RG-EIKLCDFGVSGQL-IDSMANSFVGTRSYMSPERLQGT-HYSVQSDIWSMGLSLVEMA 224 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWH----- 320 R P + +L+ +V G + + +F + + Sbjct: 225 VGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLNKFGMDSRPPMAIFELLDYI 284 Query: 321 -RFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 + E D ++ L + ER K+ M H + + Sbjct: 285 VNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAE 334 >3OMV-A nrPDB Length = 307 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 46/306 (15%), Positives = 108/306 (35%), Gaps = 60/306 (19%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK-----PVKKKKIKREIKILT 87 W + + ++G G + V++G + +K+LK P + + + E+ +L Sbjct: 31 WEIEASEVMLSTRIGSGSFGTVYKG---KWHGDVAVKILKVVDPTPEQFQAFRNEVAVLR 87 Query: 88 DLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKT 147 H NI+ + Sbjct: 88 K---------------------------------------TRHVNILLFMGYM---TKDN 105 Query: 148 PALVFEYVDNVDFRILYP----KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI 203 A+V ++ + K ++ + + +DY H+ I+HRD+K +N+ + Sbjct: 106 LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFL 165 Query: 204 DHKNKKLRLIDWGLAEF---YHVNMEYNVRVASRFFKGPELL--VDYRMYDYSLDLWSFG 258 H+ +++ D+GLA + + + S + PE++ D + + D++S+G Sbjct: 166 -HEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYG 224 Query: 259 TMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKP 318 +L ++ P+ H + + + + + D K + R D + +++ Sbjct: 225 IVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEE 284 Query: 319 WHRFIN 324 F Sbjct: 285 RPLFPQ 290 >3VHK-A nrPDB Length = 368 Score = 166 bits (419), Expect = 2e-41, Method: Composition-based stats. Identities = 67/364 (18%), Positives = 132/364 (36%), Gaps = 58/364 (15%) Query: 29 TVIDWSTNTKDYEIENKVGRGKYSEVFQGV-----KLDSKVKIVIKMLKPV----KKKKI 79 W ++ +GRG + +V + K + + +KMLK + + + Sbjct: 20 DASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRAL 79 Query: 80 KREIKILTDLSNEKVPPTTLPF-------------------QKDQYYTNQKEDVLKFIRP 120 E+KIL + + L + + E V + Sbjct: 80 MSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKG 139 Query: 121 YIFDQPHNGHANI-IHLFDIIKDPISKTPALVFEYVDNVDFRILYPK----------LTD 169 F Q + I + L + S + +V+ + + LT Sbjct: 140 ARFRQGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTL 199 Query: 170 LEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNV 229 + Y F++ K +++ S +HRD+ N+++ KN +++ D+GLA + + +Y Sbjct: 200 EHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKN-VVKICDFGLARDIYKDPDYVR 258 Query: 230 RVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVK 286 + +R + PE + D R+Y D+WSFG +L + + G VKI + Sbjct: 259 KGDARLPLKWMAPETIFD-RVYTIQSDVWSFGVLLWEIFSLGASPYPG-------VKIDE 310 Query: 287 VLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRY 346 E ++ E Y Q + WH + E+++ + NLL+ Sbjct: 311 EFCRRLKEGTRMRAPDYTTPEMY---QTMLDCWHGEPSQRPTF----SELVEHLGNLLQA 363 Query: 347 DHQE 350 + Q+ Sbjct: 364 NAQQ 367 >3C51-A nrPDB Length = 543 Score = 165 bits (418), Expect = 2e-41, Method: Composition-based stats. Identities = 64/339 (18%), Positives = 110/339 (32%), Gaps = 84/339 (24%) Query: 44 NKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQK 103 +GRG + EVF + + Sbjct: 191 RVLGRGGFGEVFACQMKATGKLYA---------------------------CKKLNKKRL 223 Query: 104 DQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRIL 163 + Q V K I + + I+ L + LV ++ D R Sbjct: 224 KKRKGYQGAMVEKKILAKVHSRF------IVSLAYAFETKTDLC--LVMTIMNGGDIRYH 275 Query: 164 Y-------PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWG 216 P + FY +++ L++ H I++RD+KP NV++D + +R+ D G Sbjct: 276 IYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLD-DDGNVRISDLG 334 Query: 217 LAEFYHVNMEYN-VRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGT 275 LA + F PELL+ YD+S+D ++ G L MI R PF Sbjct: 335 LAVELKAGQTKTKGYAGTPGFMAPELLLGEE-YDFSVDYFALGVTLYEMIAARGPFRARG 393 Query: 276 SNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDE 335 + + ++ +L+ +T P +F + Sbjct: 394 EKVE----------NKELKQRVLEQAVTYPDKF------------------------SPA 419 Query: 336 IIDLIDNLLRYDHQERL-----TAKEAMGHPWFAPIREQ 369 D + LL+ D ++RL + HP F I + Sbjct: 420 SKDFCEALLQKDPEKRLGFRDGSCDGLRTHPLFRDISWR 458 >4XCU-A nrPDB Length = 300 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 58/332 (17%), Positives = 110/332 (33%), Gaps = 73/332 (21%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGV-------KLDSKVKIVIKMLKPVKKKKIKREIKI 85 W + +G G + +V + + D + +KMLK K Sbjct: 12 WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDK------- 64 Query: 86 LTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPIS 145 D+ + + H NII+L + Sbjct: 65 ---------------------------DLADLVSEMEVMKLIGRHKNIINLLGVCTQ--E 95 Query: 146 KTPALVFEYVDNVDFRILY----------PKLTDLEIRFYMFELLKALDYCHSMGIMHRD 195 ++ E + R L+ + +++ + + Y S +HRD Sbjct: 96 GPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRD 155 Query: 196 VKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSL 252 + NV++ N +++ D+GLA H Y R + PE L D R+Y + Sbjct: 156 LAARNVLVTEDN-VMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFD-RVYTHQS 213 Query: 253 DLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMD 312 D+WSFG +L + + G V+ L + E + + P E Y + Sbjct: 214 DVWSFGILLWEIFTLGGSPYPGIP--------VEELFSLLREGHRMDRPPHCPPELYGL- 264 Query: 313 QYIRKPWHRFINDGNKHLSGNDEIIDLIDNLL 344 +R+ WH + ++++ +D +L Sbjct: 265 --MRECWHAAPSQRPTF----KQLVEALDKVL 290 >1FVR-A nrPDB Length = 327 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 53/341 (15%), Positives = 118/341 (34%), Gaps = 86/341 (25%) Query: 30 VIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKI--VIKMLK----PVKKKKIKREI 83 V+DW D + ++ +G G + +V + +++ IK +K + E+ Sbjct: 21 VLDW----NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGEL 76 Query: 84 KILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP 143 ++L L + H NII+L + Sbjct: 77 EVLCKLGH--------------------------------------HPNIINLLGACEH- 97 Query: 144 ISKTPALVFEYVDNVDFRILYPK-------------------LTDLEIRFYMFELLKALD 184 L EY + + K L+ ++ + ++ + +D Sbjct: 98 -RGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMD 156 Query: 185 YCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVD 244 Y +HRD+ N+++ +N ++ D+GL+ V ++ + + E L + Sbjct: 157 YLSQKQFIHRDLAARNILVG-ENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESL-N 214 Query: 245 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 Y +Y + D+WS+G +L ++ + G + + K+ + Y L+ + Sbjct: 215 YSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKL--------PQGYRLEKPLNC 266 Query: 305 PREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLR 345 E YD+ +R+ W + ++ +L Sbjct: 267 DDEVYDL---MRQCWREKPYERPSFAQILVS----LNRMLE 300 >4EQM-A nrPDB Length = 294 Score = 164 bits (416), Expect = 4e-41, Method: Composition-based stats. Identities = 53/239 (22%), Positives = 97/239 (40%), Gaps = 42/239 (17%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 + Y+I +K+G G S V+ +K+ IK + ++K Sbjct: 11 ERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREK------------------- 51 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 E+ LK + + H NI+ + D+ D LV EY++ Sbjct: 52 --------------EETLKRFEREVHNSSQLSHQNIVSMIDV--DEEDDCYYLVMEYIEG 95 Query: 158 ---VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLID 214 ++ + L+ + ++L + + H M I+HRD+KP N++ID NK L++ D Sbjct: 96 PTLSEYIESHGPLSVDTAINFTNQILDGIKHAHDMRIVHRDIKPQNILIDS-NKTLKIFD 154 Query: 215 WGLAEFYHVNM--EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 +G+A+ + N + + + PE D D++S G +L M+ PF Sbjct: 155 FGIAKALSETSLTQTNHVLGTVQYFSPEQAKGEAT-DECTDIYSIGIVLYEMLVGEPPF 212 >4UYA-A nrPDB Length = 340 Score = 164 bits (416), Expect = 4e-41, Method: Composition-based stats. Identities = 46/311 (14%), Positives = 104/311 (33%), Gaps = 61/311 (19%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 + E++ +G G + +V++ ++ +K + ++ + Sbjct: 26 ERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAE------------- 70 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 +R H NII L + LV E+ Sbjct: 71 -------------------SVRREARLFAMLRHPNIIELRGVCLQQPHLC--LVLEFARG 109 Query: 158 VDFRILY--PKLTDLEIRFYMFELLKALDYCHSMG---IMHRDVKPHNVMIDHK------ 206 ++ + + ++ + + Y H I+HRD+K N+++ K Sbjct: 110 GALNRALAGRRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDI 169 Query: 207 -NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 NK L++ D+GLA +H + + + PE++ ++ D+WS+G +L ++ Sbjct: 170 CNKTLKITDFGLAREWHRTTKMAT-AGAYAWMAPEVIKS-SLFSKGSDIWSYGVLLWELL 227 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 P + G + K L T P F + +++ W + + Sbjct: 228 TGEVP-YRGIDGLAVAYGVA-------VNKLTLPIPSTCPEPF---AKLMKECWQQDPHI 276 Query: 326 GNKHLSGNDEI 336 +++ Sbjct: 277 RPSFALILEQL 287 >6GVJ-A nrPDB Length = 429 Score = 164 bits (415), Expect = 5e-41, Method: Composition-based stats. Identities = 66/344 (19%), Positives = 115/344 (33%), Gaps = 99/344 (28%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK-----IKREIKILTDLSNEKV 94 Y I ++G G S+VFQ + K IK + + + EI L L Sbjct: 146 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSD 204 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 II L+D + + +V E Sbjct: 205 K-------------------------------------IIRLYDY--EITDQYIYMVME- 224 Query: 155 VDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 N+D K + E + Y +L+A+ H GI+H D+KP N +I + L+ Sbjct: 225 CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI--VDGMLK 282 Query: 212 LIDWGLAEFYHVNME---YNVRVASRFFKGPELLVDYR----------MYDYSLDLWSFG 258 LID+G+A + + +V + + PE + D D+WS G Sbjct: 283 LIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLG 342 Query: 259 TMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKP 318 +L M + + PF + +L I+ P + K Sbjct: 343 CILYYMTYGKTPFQQIINQISKLHAIID------------------PNHEIEFPDIPEK- 383 Query: 319 WHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 ++ D++ L+ D ++R++ E + HP+ Sbjct: 384 ----------------DLQDVLKCCLKRDPKQRISIPELLAHPY 411 >4H1J-A nrPDB Length = 293 Score = 164 bits (415), Expect = 6e-41, Method: Composition-based stats. Identities = 57/322 (17%), Positives = 114/322 (35%), Gaps = 70/322 (21%) Query: 31 IDWSTNTKDYEIENKVGRGKYSEVFQGV---KLDSKVKIVIKMLKPV----KKKKIKREI 83 + +D + +G G + EV++GV K+ + +K K K+K E Sbjct: 17 PQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEA 76 Query: 84 KILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP 143 I+ +L H +I+ L II++ Sbjct: 77 VIMKNLD---------------------------------------HPHIVKLIGIIEE- 96 Query: 144 ISKTPALVFEYVDNVDFRILYPK----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPH 199 + ++ E + + L L + Y ++ KA+ Y S+ +HRD+ Sbjct: 97 --EPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVR 154 Query: 200 NVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF--FKGPELLVDYRMYDYSLDLWSF 257 N+++ ++L D+GL+ + Y V + PE + ++R + + D+W F Sbjct: 155 NILVASPEC-VKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESI-NFRRFTTASDVWMF 212 Query: 258 GTMLASMI-FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIR 316 + ++ F ++PFF N D + + K L P Y + + Sbjct: 213 AVCMWEILSFGKQPFF-WLENKDVIGVLEK--------GDRLPKPDLCPPVLYTL---MT 260 Query: 317 KPWHRFINDGNKHLSGNDEIID 338 + W +D + + D Sbjct: 261 RCWDYDPSDRPRFTELVCSLSD 282 >6E4F-A nrPDB Length = 290 Score = 164 bits (414), Expect = 7e-41, Method: Composition-based stats. Identities = 55/319 (17%), Positives = 125/319 (39%), Gaps = 65/319 (20%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK--PVKKKKIKREIKILTDL 89 W + KD ++G G++ V G K + + IKM+K + + + E K++ +L Sbjct: 25 SWEIDPKDLTFLKELGTGQFGVVKYG-KWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNL 83 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 S+EK+ + L+ + + Sbjct: 84 SHEKL---------------------------------------VQLYGVCTKQ--RPIF 102 Query: 150 LVFEYVDNVD----FRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 ++ EY+ N R + + ++ ++ +A++Y S +HRD+ N +++ Sbjct: 103 IITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVND 162 Query: 206 KNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLA 262 + +++ D+GL+ + ++ EY V S+F + PE+L+ Y + D+W+FG ++ Sbjct: 163 QG-VVKVSDFGLSRYV-LDDEYTSSVGSKFPVRWSPPEVLM-YSKFSSKSDIWAFGVLMW 219 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 + + + +N++ I + L + Y + + WH Sbjct: 220 EIYSLGKMPYERFTNSETAEHI--------AQGLRLYRPHLASEKVYTI---MYSCWHEK 268 Query: 323 INDGNKHLSGNDEIIDLID 341 ++ I+D++D Sbjct: 269 ADERPTFKILLSNILDVMD 287 >4XI2-A nrPDB Length = 446 Score = 164 bits (414), Expect = 8e-41, Method: Composition-based stats. Identities = 54/319 (16%), Positives = 124/319 (38%), Gaps = 65/319 (20%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK--PVKKKKIKREIKILTDL 89 W + KD ++G G++ V G K + + IKM++ + + + E K++ +L Sbjct: 181 SWEIDPKDLTFLKELGTGQFGVVKYG-KWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNL 239 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 S+EK+ + L+ + + Sbjct: 240 SHEKL---------------------------------------VQLYGVCTKQ--RPIF 258 Query: 150 LVFEYVDNVD----FRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 ++ EY+ N R + + ++ ++ +A++Y S +HRD+ N +++ Sbjct: 259 IITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVND 318 Query: 206 KNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLA 262 + +++ D+GL+ + ++ EY V S+F + PE+L+ Y + D+W+FG ++ Sbjct: 319 QG-VVKVSDFGLSRYV-LDDEYTSSVGSKFPVRWSPPEVLM-YSKFSSKSDIWAFGVLMW 375 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 + + + +N++ I + L Y + + WH Sbjct: 376 EIYSLGKMPYERFTNSETAEHI--------AQGLRLYRPHLASERVYTI---MYSCWHEK 424 Query: 323 INDGNKHLSGNDEIIDLID 341 ++ I+D++D Sbjct: 425 ADERPSFKILLSNILDVMD 443 >2W1I-A nrPDB Length = 326 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 58/332 (17%), Positives = 118/332 (35%), Gaps = 66/332 (19%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGV----KLDSKVKIVIKMLKPVKKK---KIKREIKIL 86 + + ++G+G + V + ++ + +K L+ ++ +REI+IL Sbjct: 37 QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEIL 96 Query: 87 TDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISK 146 L H NI+ + + Sbjct: 97 KSLQ---------------------------------------HDNIVKYKGVCYSAGRR 117 Query: 147 TPALVFEYVDNVDFRILYPKLTDL----EIRFYMFELLKALDYCHSMGIMHRDVKPHNVM 202 L+ EY+ R K + ++ Y ++ K ++Y + +HRD+ N++ Sbjct: 118 NLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNIL 177 Query: 203 IDHKNKKLRLIDWGLAEFYHVNMEY---NVRVASR-FFKGPELLVDYRMYDYSLDLWSFG 258 ++++N ++++ D+GL + + EY S F+ PE L + + + + D+WSFG Sbjct: 178 VENEN-RVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESK-FSVASDVWSFG 235 Query: 259 TMLASMIF-----KREP--FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDM 311 +L + K P F N Q IV L L P E Y + Sbjct: 236 VVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMI 295 Query: 312 DQYIRKPWHRFINDGNKHLSGNDEIIDLIDNL 343 + + W+ +N + + D + Sbjct: 296 ---MTECWNNNVNQRPSFRDLALRVDQIRDQM 324 >4IAN-A nrPDB Length = 358 Score = 163 bits (412), Expect = 1e-40, Method: Composition-based stats. Identities = 65/365 (17%), Positives = 130/365 (35%), Gaps = 73/365 (20%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKL-DSKVKIVIKMLKPVK--KKKIKREIKILTDLS 90 K Y + G+G +S V + + ++ +K+++ + +K +E++ L L+ Sbjct: 26 EVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLN 85 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 + + H H + L Sbjct: 86 DADPDDKF---------------------HCLRLFRHFYHK--------------QHLCL 110 Query: 151 VFEYVDNVDFRILYPK-----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 VFE + +L L +R Y +L AL I+H D+KP N++++ Sbjct: 111 VFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNE 170 Query: 206 KNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 L+L D+G A N + + SRF++ PE+++ + YDY +D+WS G L + Sbjct: 171 SKTILKLCDFGSASHVADN-DITPYLVSRFYRAPEIIIG-KSYDYGIDMWSVGCTLYELY 228 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIR--------- 316 + F G +N L + + G +++ + + F ++ Sbjct: 229 TGKI-LFPGKTNNHMLKLAMDLKG--KMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTER 285 Query: 317 ---------KPWHRFIND-------GNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGH 360 P + D ++ DL+D +L D +R++ +A+ H Sbjct: 286 EKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQH 345 Query: 361 PWFAP 365 + Sbjct: 346 AFIQE 350 >4Y93-A nrPDB Length = 446 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 53/319 (16%), Positives = 122/319 (38%), Gaps = 65/319 (20%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK--PVKKKKIKREIKILTDL 89 W + KD ++G G++ V G K + + IKM+K + + + E K++ +L Sbjct: 182 SWEIDPKDLTFLKELGTGQFGVVKYG-KWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNL 240 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 S+EK+ + L+ + + Sbjct: 241 SHEKL---------------------------------------VQLYGVCTKQ--RPIF 259 Query: 150 LVFEYVDNVD----FRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 ++ EY+ N R + + ++ ++ +A++Y S +HRD+ N +++ Sbjct: 260 IITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVND 319 Query: 206 KNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLA 262 + +++ D+G+ + ++ EY S+F + PE+L+ Y + D+W+FG ++ Sbjct: 320 QG-VVKVSDFGMTRYV-LDDEYTSSTGSKFPVKWASPEVLM-YSKFSSKSDIWAFGVLMW 376 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 + + + +N++ I + L Y + + WH Sbjct: 377 EIYSLGKMPYERFTNSETAEHI--------AQGLRLPRPHLASERVYAI---MYSCWHEK 425 Query: 323 INDGNKHLSGNDEIIDLID 341 ++ I+D++D Sbjct: 426 ADERPTFKILLSNILDVMD 444 >3IO7-A nrPDB Length = 313 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 59/332 (17%), Positives = 119/332 (35%), Gaps = 66/332 (19%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGV----KLDSKVKIVIKMLKPVKKK---KIKREIKIL 86 + + ++G+G + V + ++ + +K L+ ++ +REI+IL Sbjct: 24 QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEIL 83 Query: 87 TDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISK 146 L H NI+ + + Sbjct: 84 KSLQ---------------------------------------HDNIVKYKGVCYSAGRR 104 Query: 147 TPALVFEYVDNVDFRILYPKLTDL----EIRFYMFELLKALDYCHSMGIMHRDVKPHNVM 202 L+ EY+ R K + ++ Y ++ K ++Y + +HRD+ N++ Sbjct: 105 NLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNIL 164 Query: 203 IDHKNKKLRLIDWGLAEFYHVNMEY---NVRVASR-FFKGPELLVDYRMYDYSLDLWSFG 258 ++++N ++++ D+GL + + EY S F+ PE L + + + + D+WSFG Sbjct: 165 VENEN-RVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESK-FSVASDVWSFG 222 Query: 259 TMLASMIF-----KREP--FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDM 311 +L + K P F N Q IV L L P E Y + Sbjct: 223 VVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMI 282 Query: 312 DQYIRKPWHRFINDGNKHLSGNDEIIDLIDNL 343 + + W+ +N + + DN+ Sbjct: 283 ---MTECWNNNVNQRPSFRDLALRVDQIRDNM 311 >4WUA-A nrPDB Length = 401 Score = 162 bits (409), Expect = 3e-40, Method: Composition-based stats. Identities = 69/414 (16%), Positives = 146/414 (35%), Gaps = 90/414 (21%) Query: 14 NINKQRTEEYWDYENTVIDWS-TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK 72 + ++ +Y ++ Y + K+G G +S V+ + K + +K++K Sbjct: 16 DDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK 75 Query: 73 PVKK--KKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGH 130 + + EI++L + N +E V++ + + + H Sbjct: 76 SAEHYTETALDEIRLLKSVRNSDPNDPN------------REMVVQLLDDFKISGVNGTH 123 Query: 131 ANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSM- 189 I +F+++ + K + Y L ++ + ++L+ LDY H+ Sbjct: 124 --ICMVFEVLGHHLLKWI-----------IKSNYQGLPLPCVKKIIQQVLQGLDYLHTKC 170 Query: 190 GIMHRDVKPHNVMI---------------------------------------------- 203 I+H D+KP N+++ Sbjct: 171 RIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPATAGNFLVNPLE 230 Query: 204 --DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTML 261 + + K+++ D G A + H + + + +R ++ E+L+ Y+ D+WS M Sbjct: 231 PKNAEKLKVKIADLGNACWVHKH--FTEDIQTRQYRSLEVLIG-SGYNTPADIWSTACMA 287 Query: 262 ASMIFKREPFFHGT-----SNTDQLVKIVKVLGT-SDFEKYLLKYEITLPREFYDMDQYI 315 + F + + D + I+++LG KY + D+ Sbjct: 288 FELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHIT 347 Query: 316 R-KPWHRFINDGNKHLSGNDEII---DLIDNLLRYDHQERLTAKEAMGHPWFAP 365 + KPW F K+ +E D + +L ++R TA E + HPW Sbjct: 348 KLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS 401 >3V5Q-A nrPDB Length = 297 Score = 161 bits (408), Expect = 3e-40, Method: Composition-based stats. Identities = 59/324 (18%), Positives = 116/324 (35%), Gaps = 86/324 (26%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVK-----LDSKVKIVIKMLKPV---KKKKIKREIKI 85 +D ++ ++G G + +VF K+ + +K LK +K +RE ++ Sbjct: 11 HIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAEL 70 Query: 86 LTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPIS 145 LT+L H +I+ + + D Sbjct: 71 LTNLQ---------------------------------------HEHIVKFYGVCGD--G 89 Query: 146 KTPALVFEYVDNVDF-------------------RILYPKLTDLEIRFYMFELLKALDYC 186 +VFEY+ + D R +L ++ ++ + Y Sbjct: 90 DPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYL 149 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLV 243 S +HRD+ N ++ N +++ D+G++ + Y V + + PE ++ Sbjct: 150 ASQHFVHRDLATRNCLVGA-NLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIM 208 Query: 244 DYRMYDYSLDLWSFGTMLASMIF-KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEI 302 YR + D+WSFG +L + ++P+F SNT+ + I + +L+ Sbjct: 209 -YRKFTTESDVWSFGVILWEIFTYGKQPWFQ-LSNTEVIECIT--------QGRVLERPR 258 Query: 303 TLPREFYDMDQYIRKPWHRFINDG 326 P+E YD + W R Sbjct: 259 VCPKEVYD---VMLGCWQREPQQR 279 >4YHJ-A nrPDB Length = 584 Score = 161 bits (407), Expect = 4e-40, Method: Composition-based stats. Identities = 70/365 (19%), Positives = 117/365 (32%), Gaps = 89/365 (24%) Query: 20 TEEYWD--YENTVIDWS------TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML 71 EEY + Y + + W + +G+G + EV + K L Sbjct: 159 FEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKL 218 Query: 72 KPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHA 131 + + KK K E L + + F Y + +D L Sbjct: 219 QKKRIKKRKGEAMALNE--KRILEKVQSRFVVSLAYAYETKDAL---------------- 260 Query: 132 NIIHLFDIIKDPISKTPALVFEYVDNVDFRILY-----PKLTDLEIRFYMFELLKALDYC 186 LV ++ D + P + FY EL L+ Sbjct: 261 -----------------CLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDL 303 Query: 187 HSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYR 246 I++RD+KP N+++D + +R+ D GLA RV + + PE++ + + Sbjct: 304 QRERIVYRDLKPENILLDDRG-HIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEK 362 Query: 247 MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPR 306 Y +S D W G ++ MI PF K +K+E R Sbjct: 363 -YTFSPDWWGLGCLIYEMIQGHSPF--------------------KKYKEKVKWEEVDQR 401 Query: 307 EFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERL-----TAKEAMGHP 361 D ++Y K +++ + LL + +RL A HP Sbjct: 402 IKNDTEEYSEK--------------FSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHP 447 Query: 362 WFAPI 366 F I Sbjct: 448 VFKDI 452 >2X7G-A nrPDB Length = 389 Score = 161 bits (406), Expect = 5e-40, Method: Composition-based stats. Identities = 66/412 (16%), Positives = 143/412 (34%), Gaps = 88/412 (21%) Query: 14 NINKQRTEEYWDYENTVIDWS-TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK 72 + ++ +Y + Y + K+G G +S V+ + K + +K++K Sbjct: 6 DEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK 65 Query: 73 PVKK--KKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGH 130 + + EIK+L + K+ V++ I + + H Sbjct: 66 SAQHYTETALDEIKLLKCVRESDPSDPN------------KDMVVQLIDDFKISGMNGIH 113 Query: 131 ANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSM- 189 ++ F+++ + K + Y L ++ + ++L+ LDY HS Sbjct: 114 VCMV--FEVLGHHLLKWI-----------IKSNYQGLPVRCVKSIIRQVLQGLDYLHSKC 160 Query: 190 GIMHRDVKPHNVMI---------------------------------------------- 203 I+H D+KP N+++ Sbjct: 161 KIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPAADLLVNPLDPR 220 Query: 204 DHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLAS 263 + ++++ D G A + H + + + +R ++ E+L+ Y D+WS M Sbjct: 221 NADKIRVKIADLGNACWVHKH--FTEDIQTRQYRSIEVLIGA-GYSTPADIWSTACMAFE 277 Query: 264 MIFKREPFFH-----GTSNTDQLVKIVKVLGT-SDFEKYLLKYEITLPREFYDMDQYIR- 316 + F + + D + I+++LG+ KY ++ + Sbjct: 278 LATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKL 337 Query: 317 KPWHRFINDGNKHLSGNDEII---DLIDNLLRYDHQERLTAKEAMGHPWFAP 365 KPW F K+ +++ D + +L ++R +A E + HPW Sbjct: 338 KPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS 389 >3ORP-A nrPDB Length = 311 Score = 161 bits (406), Expect = 7e-40, Method: Composition-based stats. Identities = 64/327 (19%), Positives = 111/327 (33%), Gaps = 58/327 (17%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPP 96 + YE+ +G G SEV L + +K+L+ Sbjct: 11 SDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRAD---------------------- 48 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDI--IKDPISKTPALVFEY 154 + R + H I+ ++D + P P +V EY Sbjct: 49 -----------LARDPSFYLRFRREAQNAAALNHPAIVAVYDTGEAETPAGPLPYIVMEY 97 Query: 155 VDNVDFRIL---YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 VD V R + +T + + +AL++ H GI+HRDVKP N+MI N ++ Sbjct: 98 VDGVTLRDIVHTEGPMTPKRAIEVIADACQALNFSHQNGIIHRDVKPANIMISATNA-VK 156 Query: 212 LIDWGLAEFYHVNMEYNVR----VASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 ++D+G+A + + + + + PE + D D++S G +L ++ Sbjct: 157 VMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQARGDSV-DARSDVYSLGCVLYEVLTG 215 Query: 268 REPFFHGTSNTDQLVKIVKVLGTS----------DFEKYLLKYEITLPREFYDMDQYIRK 317 PF G S + V+ D + +LK P Y +R Sbjct: 216 EPPF-TGDSPVSVAYQHVREDPIPPSARHEGLSADLDAVVLKALAKNPENRYQTAAEMRA 274 Query: 318 PWHRFINDGNKHLSG---NDEIIDLID 341 R N + E L+ Sbjct: 275 DLVRVHNGEPPEAPKVLTDAERTSLLS 301 >3HMP-A nrPDB Length = 342 Score = 160 bits (405), Expect = 8e-40, Method: Composition-based stats. Identities = 69/387 (17%), Positives = 125/387 (32%), Gaps = 104/387 (26%) Query: 2 KCRVWSEARVYTNINKQRTEEYWDYENTVID-----WSTNTKDYEIENKVGRGKYSEVFQ 56 + A + + + D ++ S + Y I ++G G S+VFQ Sbjct: 15 SGMKETAAAKFERQHMDSPDLGTDDDDKASSSANECISVKGRIYSILKQIGSGGSSKVFQ 74 Query: 57 GVKLDSKVKIVIKMLKPVKKKK-----IKREIKILTDLSNEKVPPTTLPFQKDQYYTNQK 111 + K IK + + + EI L L Sbjct: 75 VLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDK---------------- 117 Query: 112 EDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK---LT 168 II L+D + + +V E N+D K + Sbjct: 118 ---------------------IIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKSID 153 Query: 169 DLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME-- 226 E + Y +L+A+ H GI+H D+KP N +I + L+LID+G+A + Sbjct: 154 PWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSV 211 Query: 227 -YNVRVASRFFKGPELLVDYR----------MYDYSLDLWSFGTMLASMIFKREPFFHGT 275 + +V + + PE + D D+WS G +L M + + PF Sbjct: 212 VKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQII 271 Query: 276 SNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDE 335 + +L I+ P + K + Sbjct: 272 NQISKLHAIID------------------PNHEIEFPDIPEK-----------------D 296 Query: 336 IIDLIDNLLRYDHQERLTAKEAMGHPW 362 + D++ L+ D ++R++ E + HP+ Sbjct: 297 LQDVLKCCLKRDPKQRISIPELLAHPY 323 >5O0Y-A nrPDB Length = 579 Score = 160 bits (404), Expect = 9e-40, Method: Composition-based stats. Identities = 60/340 (17%), Positives = 120/340 (35%), Gaps = 81/340 (23%) Query: 51 YSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQ 110 +SEV++ L + + +K+ + + Sbjct: 297 FSEVYKAFDLTEQRYVAVKI-----------------------------HQLNKNWRDEK 327 Query: 111 KEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK---L 167 KE+ K H I+ L+D + + V EY + D + + Sbjct: 328 KENYHKHACREYRIHKELDHPRIVKLYDYF-SLDTDSFCTVLEYCEGNDLDFYLKQHKLM 386 Query: 168 TDLEIRFYMFELLKALDYCHSMG--IMHRDVKPHNVMIDHKN--KKLRLIDWGLAEFYHV 223 ++ E R + +++ AL Y + + I+H D+KP N+++ + ++++ D+GL++ Sbjct: 387 SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDD 446 Query: 224 NMEYNVR--------VASRFFKGPELLV---DYRMYDYSLDLWSFGTMLASMIFKREPFF 272 + +V + ++ PE V + +D+WS G + ++ R+PF Sbjct: 447 DSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFG 506 Query: 273 HGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSG 332 H S D L E +LK Q+ KP Sbjct: 507 HNQSQQDILQ-----------ENTILKATEV---------QFPPKP------------VV 534 Query: 333 NDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP-IREQIE 371 E I L Y ++R+ ++ P+ P IR+ + Sbjct: 535 TPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVS 574 >5VO2-A nrPDB Length = 300 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 53/342 (15%), Positives = 112/342 (32%), Gaps = 80/342 (23%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNE 92 W ++ VG G VF G ++ +K ++ +K+ IK L L Sbjct: 7 WEVPFEEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKETDIKH----LRKLK-- 58 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF 152 H NII + ++ Sbjct: 59 -------------------------------------HPNIITFKGVCTQAPCYC--ILM 79 Query: 153 EYVDNVDFRILYP---KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 E+ + +T + + + ++Y H I+HRD+K N++I + + Sbjct: 80 EFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDD-V 138 Query: 210 LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 +++ D+G ++ + + PE++ + +D+WSFG +L ++ Sbjct: 139 VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRN-EPVSEKVDIWSFGVVLWELLTGEI 197 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 P+ S+ I+ +G++ L + P F + +R+ W+ + Sbjct: 198 PYKDVDSSA-----IIWGVGSNSLH---LPVPSSCPDGFKIL---LRQCWNSKPRNRPSF 246 Query: 330 LSGNDEIIDLIDNLLRYDHQERLTAKEAMGHP---WFAPIRE 368 LL D + + + + P +F E Sbjct: 247 RQI----------LLHLD----IASADVLSTPQETYFKSQAE 274 >4HVI-A nrPDB Length = 314 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 54/332 (16%), Positives = 123/332 (37%), Gaps = 77/332 (23%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKL----DSKVKIVIKMLK---PVKKKKIKREIKILT 87 + + +++G+G + V ++ + +K L+ P +++ +REI+IL Sbjct: 7 FEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILK 66 Query: 88 DLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKT 147 L ++ I+ + P ++ Sbjct: 67 ALHSDF---------------------------------------IVKYRGVSYGPGRQS 87 Query: 148 PALVFEYVDNVDFRILYPK----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI 203 LV EY+ + R + L + Y ++ K ++Y S +HRD+ N+++ Sbjct: 88 LRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILV 147 Query: 204 DHKNKKLRLIDWGLAEFYHVNMEYNVRV----ASRFFKGPELLVDYRMYDYSLDLWSFGT 259 + + +++ D+GLA+ ++ +Y V + F+ PE L D ++ D+WSFG Sbjct: 148 ESE-AHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSD-NIFSRQSDVWSFGV 205 Query: 260 MLASMIFKREPFFHGTSNTDQLVKIVKVLGTS------------DFEKYLLKYEITLPRE 307 +L + F + + + ++++G+ E L P E Sbjct: 206 VLYEL------FTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQRLPAPPACPAE 259 Query: 308 FYDMDQYIRKPWHRFINDGNKHLSGNDEIIDL 339 +++ ++ W D + ++ L Sbjct: 260 VHEL---MKLCWAPSPQDRPSFSALGPQLDML 288 >4AT3-A nrPDB Length = 299 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 55/334 (16%), Positives = 121/334 (36%), Gaps = 83/334 (24%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLD-----SKVKIVIKMLKPVK---KKKIKREIKI 85 + ++ ++G G + +VF + K+ + +K LK +K RE ++ Sbjct: 9 HIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAEL 68 Query: 86 LTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPIS 145 LT+L H +I+ + + + Sbjct: 69 LTNLQ---------------------------------------HEHIVKFYGVCVE--G 87 Query: 146 KTPALVFEYVDNVDFRILYP----------------KLTDLEIRFYMFELLKALDYCHSM 189 +VFEY+ + D +LT ++ ++ + Y S Sbjct: 88 DPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQ 147 Query: 190 GIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYR 246 +HRD+ N ++ +N +++ D+G++ + Y V + + PE ++ YR Sbjct: 148 HFVHRDLATRNCLVG-ENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIM-YR 205 Query: 247 MYDYSLDLWSFGTMLASMIF-KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLP 305 + D+WS G +L + ++P++ SN + + I + +L+ T P Sbjct: 206 KFTTESDVWSLGVVLWEIFTYGKQPWYQ-LSNNEVIECIT--------QGRVLQRPRTCP 256 Query: 306 REFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDL 339 +E Y++ + W R + + + +L Sbjct: 257 QEVYEL---MLGCWQREPHMRKNIKGIHTLLQNL 287 >3QGY-A nrPDB Length = 286 Score = 159 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 50/322 (15%), Positives = 115/322 (35%), Gaps = 72/322 (22%) Query: 31 IDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK--PVKKKKIKREIKILTD 88 + + + ++G G++ V G L +K K+ IK +K + + E +++ Sbjct: 20 LHMVIDPSELTFVQEIGSGQFGLVHLGYWL-NKDKVAIKTIKEGSMSEDDFIEEAEVMMK 78 Query: 89 LSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTP 148 LS H ++ L+ + + Sbjct: 79 LS---------------------------------------HPKLVQLYGVCLEQA--PI 97 Query: 149 ALVFEYVDNVDF----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMID 204 LVFE++++ R + ++ + + Y ++HRD+ N ++ Sbjct: 98 CLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVG 157 Query: 205 HKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTML 261 +N+ +++ D+G+ F ++ +Y ++F + PE+ + Y D+WSFG ++ Sbjct: 158 -ENQVIKVSDFGMTRFV-LDDQYTSSTGTKFPVKWASPEV-FSFSRYSSKSDVWSFGVLM 214 Query: 262 ASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 + + + + SN++ + I ++ F Y + T + Q + W Sbjct: 215 WEVFSEGKIPYENRSNSEVVEDI-----STGFRLYKPRLAST------HVYQIMNHCWKE 263 Query: 322 FINDGNKHLSGNDEIIDLIDNL 343 D L+ L Sbjct: 264 RPEDRPAFSR-------LLRQL 278 >2ZMD-A nrPDB Length = 390 Score = 158 bits (400), Expect = 3e-39, Method: Composition-based stats. Identities = 69/387 (17%), Positives = 125/387 (32%), Gaps = 104/387 (26%) Query: 2 KCRVWSEARVYTNINKQRTEEYWDYENTVID-----WSTNTKDYEIENKVGRGKYSEVFQ 56 + A + + + D ++ S + Y I ++G G S+VFQ Sbjct: 15 SGMKETAAAKFERQHMDSPDLGTDDDDKASSSANECISVKGRIYSILKQIGSGGSSKVFQ 74 Query: 57 GVKLDSKVKIVIKMLKPVKKKK-----IKREIKILTDLSNEKVPPTTLPFQKDQYYTNQK 111 + K IK + + + EI L L Sbjct: 75 VLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDK---------------- 117 Query: 112 EDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK---LT 168 II L+D + + +V E N+D K + Sbjct: 118 ---------------------IIRLYDY--EITDQYIYMVME-CGNIDLNSWLKKKKSID 153 Query: 169 DLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME-- 226 E + Y +L+A+ H GI+H D+KP N +I + L+LID+G+A + Sbjct: 154 PWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSV 211 Query: 227 -YNVRVASRFFKGPELLVDYR----------MYDYSLDLWSFGTMLASMIFKREPFFHGT 275 + +V + + PE + D D+WS G +L M + + PF Sbjct: 212 VKDSQVGAVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQII 271 Query: 276 SNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDE 335 + +L I+ P + K + Sbjct: 272 NQISKLHAIID------------------PNHEIEFPDIPEK-----------------D 296 Query: 336 IIDLIDNLLRYDHQERLTAKEAMGHPW 362 + D++ L+ D ++R++ E + HP+ Sbjct: 297 LQDVLKCCLKRDPKQRISIPELLAHPY 323 >5AP3-A nrPDB Length = 313 Score = 158 bits (400), Expect = 3e-39, Method: Composition-based stats. Identities = 66/352 (18%), Positives = 116/352 (32%), Gaps = 99/352 (28%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK-----IKREIKIL 86 S + Y I ++G G S+VFQ + K IK + + + EI L Sbjct: 22 SMSVKGRIYSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRNEIAYL 80 Query: 87 TDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISK 146 L II L+D + + Sbjct: 81 NKLQQHSDK-------------------------------------IIRLYDY--EITDQ 101 Query: 147 TPALVFEYVDNVDF---RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI 203 +V E N+D + E + Y +L+A+ H GI+H D+KP N +I Sbjct: 102 YIYMVME-CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLI 160 Query: 204 DHKNKKLRLIDWGLAEFYHVNME---YNVRVASRFFKGPELLVDYR----------MYDY 250 + L+LID+G+A + + +V + + PE + D Sbjct: 161 --VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISP 218 Query: 251 SLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYD 310 D+WS G +L M + + PF + +L I+ P + Sbjct: 219 KSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIID------------------PNHEIE 260 Query: 311 MDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 K ++ D++ L+ D ++R++ E + HP+ Sbjct: 261 FPDIPEK-----------------DLQDVLKCCLKRDPKQRISIPELLAHPY 295 >5AMN-A nrPDB Length = 299 Score = 158 bits (400), Expect = 3e-39, Method: Composition-based stats. Identities = 51/341 (14%), Positives = 120/341 (35%), Gaps = 83/341 (24%) Query: 31 IDWSTNTKDYEIENKVGRGKYSEVFQGV--KLDSK---VKIVIKMLK----PVKKKKIKR 81 W K+ + +G G++ +V + L + + +KMLK P + + + Sbjct: 16 PKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLS 75 Query: 82 EIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIK 141 E +L ++ H ++I L+ Sbjct: 76 EFNVLKQVN---------------------------------------HPHVIKLYGACS 96 Query: 142 DPISKTPALVFEYVDNVDFRILYPK-------------LTDLEIRFYMFELLKALDYCHS 188 L+ EY R + LT ++ + +++ + + Y Sbjct: 97 Q--DGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAWQISQGMQYLAE 154 Query: 189 MGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDY 245 M ++HRD+ N+++ + +K+++ D+GL+ + Y R R + E L D+ Sbjct: 155 MKLVHRDLAARNILV-AEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDH 213 Query: 246 RMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLP 305 +Y D+WSFG +L ++ + G ++L ++K + ++ Sbjct: 214 -IYTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLLKT-------GHRMERPDNCS 264 Query: 306 REFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRY 346 E Y + + + W + + + + ++ ++ Sbjct: 265 EEMY---RLMLQCWKQEPDKRPVFADISKD----LEKMMVK 298 >4XLV-A nrPDB Length = 328 Score = 157 bits (398), Expect = 5e-39, Method: Composition-based stats. Identities = 52/367 (14%), Positives = 120/367 (32%), Gaps = 112/367 (30%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQG-----VKLDSKVKIVIKMLKP----VKKKKIKRE 82 +W + + + ++G+G + V++G +K +++ ++ +K + ++ + E Sbjct: 33 EWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNE 92 Query: 83 IKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD 142 ++ H +++ L ++ Sbjct: 93 ASVMK--------------------------------------GFTCH-HVVRLLGVVSK 113 Query: 143 PISKTPALVFEYVDNVDFRILYPKLTDL-------------EIRFYMFELLKALDYCHSM 189 + +V E + + D + L E+ E+ + Y ++ Sbjct: 114 --GQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAK 171 Query: 190 GIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVA----SRFFKGPELLVDY 245 +HRD+ N M+ H + +++ D+G+ + +Y + + PE L D Sbjct: 172 KFVHRDLAARNCMVAH-DFTVKIGDFGMTRDIYE-TDYYRKGGKGLLPVRWMAPESLKD- 228 Query: 246 RMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLP 305 ++ S D+WSFG +L + E + G SN L ++ + L P Sbjct: 229 GVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVM--------DGGYLDQPDNCP 280 Query: 306 REFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMG------ 359 + + DL+ +++ R T E + Sbjct: 281 ----------------------------ERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDL 312 Query: 360 HPWFAPI 366 HP F + Sbjct: 313 HPSFPEV 319 >4PL5-B nrPDB Length = 435 Score = 157 bits (398), Expect = 5e-39, Method: Composition-based stats. Identities = 69/376 (18%), Positives = 132/376 (35%), Gaps = 99/376 (26%) Query: 15 INKQRTEEYWDYENTVIDWSTNTK-DYEIENKVGRGKYSE-VFQGVKLDSKVKIVIKMLK 72 ++ + D E+ K + ++ +G G V++G + + +K + Sbjct: 3 MDPEFPSLEQDDEDEETRMVIVGKISFCPKDVLGHGAEGTIVYKG--MFDNRDVAVKRIL 60 Query: 73 PVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHAN 132 P RE+++L + H N Sbjct: 61 PECFSFADREVQLLRESDE--------------------------------------HPN 82 Query: 133 IIHLFDIIKDPISKTPALVF------EYVDNVDFRILYPKLTDLEIRFYMFELLKALDYC 186 +I F KD + A+ EYV+ DF L LE + + L + Sbjct: 83 VIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLG-----LEPITLLHQTTSGLAHL 137 Query: 187 HSMGIMHRDVKPHNVMIDHKN--KKLR--LIDWGLAEFY----HVNMEYNVRVASRFFKG 238 HS+ I+HRD+KPHN+++ N +++ + D+GL + H + + + Sbjct: 138 HSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIA 197 Query: 239 PELLVDYRMY--DYSLDLWSFGTMLASMIF-KREPFFHGTSNTDQLVKIVKVLGTSDFEK 295 PE+L + Y++D++S G + +I PF G S Q ++ F Sbjct: 198 PEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF--GKSLQRQANILLGACNLDCFHS 255 Query: 296 YLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAK 355 + I +LI+ ++ D Q+R +AK Sbjct: 256 DKHEDVI---------------------------------ARELIEKMIAMDPQQRPSAK 282 Query: 356 EAMGHPWFAPIREQIE 371 + HP+F + +Q++ Sbjct: 283 HVLKHPFFWSLEKQLQ 298 >4AN9-A nrPDB Length = 301 Score = 157 bits (396), Expect = 8e-39, Method: Composition-based stats. Identities = 58/344 (16%), Positives = 114/344 (33%), Gaps = 88/344 (25%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML----KPVKKKKIKREIKILTDL 89 D+E +++G G VF+ S + + K++ KP + +I RE+++L + Sbjct: 5 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC 64 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 ++ I+ + + Sbjct: 65 NS---------------------------------------PYIVGFYGAFYSDGE--IS 83 Query: 150 LVFEYVDNVDFRILYP---KLTDLEIRFYMFELLKALDYC-HSMGIMHRDVKPHNVMIDH 205 + E++D + ++ + + ++K L Y IMHRDVKP N++++ Sbjct: 84 ICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNS 143 Query: 206 KNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 + +++L D+G++ ++ N V +R + PE L Y D+WS G L M Sbjct: 144 RG-EIKLCDFGVSGQL-IDEMANEFVGTRSYMSPERLQGT-HYSVQSDIWSMGLSLVEMA 200 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 R P P +++ YI Sbjct: 201 VGRYP--------------------------------RPPMAIFELLDYI----VNEPPP 224 Query: 326 GNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQ 369 + E D ++ L + ER K+ M H + + Sbjct: 225 KLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAE 268 >3UIU-A nrPDB Length = 306 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 55/299 (18%), Positives = 113/299 (37%), Gaps = 23/299 (7%) Query: 39 DYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTT 98 D++ +G G + +VF+ VI+ +K +K +RE+K L L + + Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVK-YNNEKAEREVKALAKLDHVNIVHYN 71 Query: 99 LPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNV 158 + Y +D L+ + ++ +K + E+ D Sbjct: 72 GCWDGFDYDPETSDDSLESSDYDPENSKNSS------------RSKTKCLFIQMEFCDKG 119 Query: 159 DF-----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLI 213 + KL + ++ K +DY HS ++HRD+KP N+ + K++++ Sbjct: 120 TLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFL-VDTKQVKIG 178 Query: 214 DWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI-FKREPFF 272 D+GL + + + + PE + + Y +DL++ G +LA ++ F Sbjct: 179 DFGLVTSLKNDGKRTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELLHVCDTAFE 237 Query: 273 HGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKP--WHRFINDGNKH 329 TD I+ + + L K P + + + +R W + +H Sbjct: 238 TSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERH 296 >2PMN-X nrPDB Length = 348 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 74/342 (21%), Positives = 131/342 (38%), Gaps = 56/342 (16%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPP 96 DY I + +GK++++ K +K K E +L + Sbjct: 30 INDYRIIRTLNQGKFNKIILCEK--DNKFYALK----------KYEKSLLEKKRDFTKSN 77 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 K +Y + E I I ++ II +D +++EY++ Sbjct: 78 NDKISIKSKYDDFKNE---LQIITDIKNEYCLTCEGIITNYD--------EVYIIYEYME 126 Query: 157 NVDFRILYPKLTDLE-----------IRFYMFELLKALDYCH-SMGIMHRDVKPHNVMID 204 N L+ I+ + +L + Y H I HRDVKP N+++D Sbjct: 127 NDSILKFDEYFFVLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMD 186 Query: 205 HKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMY-DYSLDLWSFGTMLAS 263 KN +++L D+G +E+ V+ + + F PE + Y +D+WS G L Sbjct: 187 -KNGRVKLSDFGESEYM-VDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYV 244 Query: 264 MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFI 323 M + PF S LV++ + T + E L + P + + F+ Sbjct: 245 MFYNVVPFSLKIS----LVELFNNIRTKNIEYPLDRNHFLYP-----LTNKKSTCSNNFL 295 Query: 324 NDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAP 365 ++ E ID + LR + ER+T+++A+ H W A Sbjct: 296 SN---------EDIDFLKLFLRKNPAERITSEDALKHEWLAD 328 >5CEK-A nrPDB Length = 263 Score = 156 bits (394), Expect = 1e-38, Method: Composition-based stats. Identities = 53/287 (18%), Positives = 99/287 (34%), Gaps = 41/287 (14%) Query: 85 ILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI 144 +L L+ + L + + + + H+NI + ++I Sbjct: 15 LLLPLAEREHVSRALCIHTGRELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGET 74 Query: 145 SKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHN-VMI 203 ++ D + +L + E +++ A+ +CH I+ D+K V Sbjct: 75 KAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFS 134 Query: 204 DHKNKKLRLIDWGLAEFYH-VNMEYNVRVASRFFKGPELLVDYRMY-DYSLDLWSFGTML 261 + +LRL + + + + PE+L Y + D+WS G ML Sbjct: 135 TEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVML 194 Query: 262 ASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 +++ R PF H + + KI + + +P Sbjct: 195 YTLLVGRYPF-HDSDPSALFSKI-------------RRGQFCIPEHI------------- 227 Query: 322 FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 368 + + LI +LLR + ERLTA E + HPWF + E Sbjct: 228 -----------SPKARCLIRSLLRREPSERLTAPEILLHPWFESVLE 263 >6DC0-A nrPDB Length = 292 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 53/287 (18%), Positives = 99/287 (34%), Gaps = 41/287 (14%) Query: 85 ILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI 144 +L L+ + L + + + + H+NI + ++I Sbjct: 12 LLLPLAEREHVSRALCIHTGRELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGET 71 Query: 145 SKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHN-VMI 203 ++ D + +L + E +++ A+ +CH I+ D+K V Sbjct: 72 KAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFS 131 Query: 204 DHKNKKLRLIDWGLAEFYH-VNMEYNVRVASRFFKGPELLVDYRMY-DYSLDLWSFGTML 261 + +LRL + + + + PE+L Y + D+WS G ML Sbjct: 132 TEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVML 191 Query: 262 ASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 +++ R PF H + + KI + + +P Sbjct: 192 YTLLVGRYPF-HDSDPSALFSKI-------------RRGQFCIPEHI------------- 224 Query: 322 FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 368 + + LI +LLR + ERLTA E + HPWF + E Sbjct: 225 -----------SPKARCLIRSLLRREPSERLTAPEILLHPWFESVLE 260 >2RIO-A nrPDB Length = 434 Score = 156 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 63/377 (16%), Positives = 126/377 (33%), Gaps = 110/377 (29%) Query: 30 VIDWSTNTKDYEI-ENKVGRGKYSEV-FQGVKLDSKVKIVIKMLKPVKKKKIKREIKILT 87 + ++ + K+ + E +G G V FQG + +K + EIK+LT Sbjct: 6 IPNFEQSLKNLVVSEKILGYGSSGTVVFQGSFQ--GRPVAVKRMLIDFCDIALMEIKLLT 63 Query: 88 DLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKT 147 + + H N+I + + + Sbjct: 64 ESDD--------------------------------------HPNVIRYY--CSETTDRF 83 Query: 148 PALVFEYVDNVDFRILYPK---------LTDLEIRFYMFELLKALDYCHSMGIMHRDVKP 198 + E + ++ K + + ++ + + HS+ I+HRD+KP Sbjct: 84 LYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHSLKIIHRDLKP 143 Query: 199 HNVMID------------HKNKKLRLIDWGLAEFYHVNM-----EYNVRVASRFFKGPEL 241 N+++ +N ++ + D+GL + N + ++ PEL Sbjct: 144 QNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSGTSGWRAPEL 203 Query: 242 LVDY------RMYDYSLDLWSFGTMLASMIF-KREPFFHGTSNTDQLVKIVKVLGTSDFE 294 L + R S+D++S G + ++ + PF S I++ + + D Sbjct: 204 LEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRES---NIIRGIFSLDEM 260 Query: 295 KYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTA 354 K L S E DLI ++ +D +R TA Sbjct: 261 KCL------------------------------HDRSLIAEATDLISQMIDHDPLKRPTA 290 Query: 355 KEAMGHPWFAPIREQIE 371 + + HP F P +++E Sbjct: 291 MKVLRHPLFWPKSKKLE 307 >5HLW-A nrPDB Length = 299 Score = 156 bits (393), Expect = 2e-38, Method: Composition-based stats. Identities = 58/298 (19%), Positives = 107/298 (35%), Gaps = 55/298 (18%) Query: 41 EIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLP 100 +GRG + V+ G LD+ KKI +K L +++ Sbjct: 23 HFNEVIGRGHFGCVYHGTLLDN------------DGKKIHCAVKSLNRITDIG------- 63 Query: 101 FQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDF 160 +V +F+ I + H N++ L I +P +V Y+ + D Sbjct: 64 ------------EVSQFLTEGIIMKD-FSHPNVLSLLGICLRS-EGSPLVVLPYMKHGDL 109 Query: 161 RILY----PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWG 216 R T ++ + ++ K + Y S +HRD+ N M+D K +++ D+G Sbjct: 110 RNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEK-FTVKVADFG 168 Query: 217 LAEFYHVNMEYNV--RVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 LA H Y+V + ++ + E L + + D+WSFG +L ++ + P Sbjct: 169 LARDMHDKEYYSVHNKTGAKLPVKWMALESLQTQK-FTTKSDVWSFGVLLWELMTRGAPP 227 Query: 272 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 + + D + + L P Y+ + K WH Sbjct: 228 YPDVNTFD--------ITVYLLQGRRLLQPEYCPDPLYE---VMLKCWHPKAEMRPSF 274 >1S9I-A nrPDB Length = 354 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 56/357 (15%), Positives = 121/357 (33%), Gaps = 64/357 (17%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML----KPVKKKKIKREIKILTDL 89 D+E +++G G V + S + + K++ KP + +I RE+++L + Sbjct: 12 ELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHEC 71 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 ++ I+ + + Sbjct: 72 NS---------------------------------------PYIVGFYGAFYSDGE--IS 90 Query: 150 LVFEYVDNVDFRILYP---KLTDLEIRFYMFELLKALDYC-HSMGIMHRDVKPHNVMIDH 205 + E++D + ++ + + +L+ L Y IMHRDVKP N++++ Sbjct: 91 ICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNS 150 Query: 206 KNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 + +++L D+G++ ++ N V +R + PE L Y D+WS G L + Sbjct: 151 RG-EIKLCDFGVSGQL-IDSMANSFVGTRSYMAPERLQGT-HYSVQSDIWSMGLSLVELA 207 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWH----- 320 R P + + + V+ + E + + P +P Sbjct: 208 VGRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPRPPGRPVSGHGMDSRPAMAIFEL 267 Query: 321 -----RFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK 372 + + + ++ L + ER K H + R ++E+ Sbjct: 268 LDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIK--RSEVEE 322 >5FM2-A nrPDB Length = 355 Score = 155 bits (391), Expect = 3e-38, Method: Composition-based stats. Identities = 55/358 (15%), Positives = 132/358 (36%), Gaps = 54/358 (15%) Query: 4 RVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGV--KLD 61 R S + ++ + D W K+ + +G G++ +V + L Sbjct: 35 RRPSLDSMENQVSVDAFKILEDP-----KWEFPRKNLVLGKTLGEGEFGKVVKATAFHLK 89 Query: 62 SK---VKIVIKMLK----PVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDV 114 + + +KMLK P + + + E +L +++ V Y ++ Sbjct: 90 GRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKL--------YGACSQDGP 141 Query: 115 LKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYP---KLTDLE 171 L I Y L +++ P + + +P LT + Sbjct: 142 LLLIVEYAKYGS---------LRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGD 192 Query: 172 IRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRV 231 + + +++ + + Y M ++HRD+ N+++ + +K+++ D+GL+ + Y R Sbjct: 193 LISFAWQISQGMQYLAEMKLVHRDLAARNILV-AEGRKMKISDFGLSRDVYEEDSYVKRS 251 Query: 232 ASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVL 288 R + E L D+ +Y D+WSFG +L ++ + G ++L ++K Sbjct: 252 QGRIPVKWMAIESLFDH-IYTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLLKT- 308 Query: 289 GTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRY 346 + ++ E Y + + + W + + + + ++ ++ Sbjct: 309 ------GHRMERPDNCSEEMY---RLMLQCWKQEPDKRPVFADISKD----LEKMMVK 353 >5X5O-A nrPDB Length = 310 Score = 155 bits (391), Expect = 4e-38, Method: Composition-based stats. Identities = 56/318 (17%), Positives = 114/318 (35%), Gaps = 72/318 (22%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 93 D + G G + V++ + ++ +K L KI++E +IL+ LS Sbjct: 11 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL-----LKIEKEAEILSVLS--- 62 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 H NII + +I +P + +V E Sbjct: 63 ------------------------------------HRNIIQFYGVILEPPNY--GIVTE 84 Query: 154 YVDNVDFRILY-----PKLTDLEIRFYMFELLKALDYCHSM---GIMHRDVKPHNVMIDH 205 Y ++ I + ++ K + Y H ++HRD+K NV+I Sbjct: 85 YASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAA 144 Query: 206 KNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 + L++ D+G + +H + + V + + PE++ + D +S+G +L M+ Sbjct: 145 -DGVLKICDFGASR-FHNHTTHMSLVGTFPWMAPEVIQSL-PVSETCDTYSYGVVLWEML 201 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 + PF G +V+ L + PR F ++ + + W Sbjct: 202 TREVPF-KGLEGLQVAWLVVEK-------NERLTIPSSCPRSFAEL---LHQCWEADAKK 250 Query: 326 GNKHLSGNDEIIDLIDNL 343 +II +++++ Sbjct: 251 RPSF----KQIISILESM 264 >3ZBF-A nrPDB Length = 322 Score = 155 bits (391), Expect = 4e-38, Method: Composition-based stats. Identities = 54/346 (15%), Positives = 120/346 (34%), Gaps = 82/346 (23%) Query: 20 TEEYWDYENTVID--WSTNTKDYEIENKVGRGKYSEVFQGVKLD------SKVKIVIKML 71 Y I+ + + + +G G + EV++G +D ++K+ +K L Sbjct: 13 PTTENLYFQGSIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTL 72 Query: 72 KP----VKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPH 127 K +K + +E +++ Sbjct: 73 KKGSTDQEKIEFLKEAHLMSK--------------------------------------- 93 Query: 128 NGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK----------LTDLEIRFYMF 177 H NI+ + +++ ++ E ++ D K LT +++ Sbjct: 94 FNHPNILKQLGVCL--LNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCV 151 Query: 178 ELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK----LRLIDWGLAEFYHVNMEYNVR--- 230 ++ K Y M +HRD+ N ++ K+ +++ D+GLA + N Y R Sbjct: 152 DISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEG 211 Query: 231 VASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGT 290 + + PE L+D ++ D+WSFG ++ ++ + SN D L + Sbjct: 212 LLPVRWMAPESLMD-GIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYV------ 264 Query: 291 SDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEI 336 L+ P + +++ + + W + + D++ Sbjct: 265 --QTGGRLEPPRNCPDDLWNL---MTQCWAQEPDQRPTFHRIQDQL 305 >4HZS-A nrPDB Length = 341 Score = 154 bits (390), Expect = 4e-38, Method: Composition-based stats. Identities = 57/324 (17%), Positives = 110/324 (33%), Gaps = 63/324 (19%) Query: 28 NTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVK---IVIKMLKPVKKKKIKREIK 84 + + KD + K+G G + V +G K + +K LKP Sbjct: 2 SQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPD---------- 51 Query: 85 ILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI 144 +L+ + + + H N+I L+ ++ P Sbjct: 52 VLSQ-----------------------PEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPP 88 Query: 145 SKTPALVFEYVDNVDFRILYPK----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHN 200 K +V E K + Y ++ + + Y S +HRD+ N Sbjct: 89 MK---MVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARN 145 Query: 201 VMIDHKNKKLRLIDWGLAEFYHVNMEYNV----RVASRFFKGPELLVDYRMYDYSLDLWS 256 +++ ++ +++ D+GL N ++ V R + PE L R + ++ D W Sbjct: 146 LLLATRDL-VKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKT-RTFSHASDTWM 203 Query: 257 FGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIR 316 FG L M + + G + + L KI D E L P++ Y+ + Sbjct: 204 FGVTLWEMFTYGQEPWIGLNGSQILHKI-------DKEGERLPRPEDCPQDIYN---VMV 253 Query: 317 KPWHRFINDGNKHLSGNDEIIDLI 340 + W D ++ + D + Sbjct: 254 QCWAHKPEDRPTFVA----LRDFL 273 >5KMM-A nrPDB Length = 329 Score = 154 bits (390), Expect = 5e-38, Method: Composition-based stats. Identities = 56/345 (16%), Positives = 120/345 (34%), Gaps = 85/345 (24%) Query: 25 DYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLD-----SKVKIVIKMLKPVK---K 76 Y + +D ++ ++G G + +VF + K+ + +K LK + Sbjct: 22 QYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESAR 81 Query: 77 KKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHL 136 + +RE ++LT L H +I+ Sbjct: 82 QDFQREAELLTMLQ---------------------------------------HQHIVRF 102 Query: 137 FDIIKDPISKTPALVFEYVDNVDFRILYPK------------------LTDLEIRFYMFE 178 F + + + +VFEY+ + D L ++ + Sbjct: 103 FGVCTE--GRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQ 160 Query: 179 LLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF--- 235 + + Y + +HRD+ N ++ + +++ D+G++ + Y V + Sbjct: 161 VAAGMVYLAGLHFVHRDLATRNCLVG-QGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIR 219 Query: 236 FKGPELLVDYRMYDYSLDLWSFGTMLASMIF-KREPFFHGTSNTDQLVKIVKVLGTSDFE 294 + PE ++ YR + D+WSFG +L + ++P++ SNT+ + I + Sbjct: 220 WMPPESIL-YRKFTTESDVWSFGVVLWEIFTYGKQPWYQ-LSNTEAIDCIT--------Q 269 Query: 295 KYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDL 339 L+ P E Y + +R W R + + + L Sbjct: 270 GRELERPRACPPEVYAI---MRGCWQREPQQRHSIKDVHARLQAL 311 >1LUF-A nrPDB Length = 343 Score = 154 bits (389), Expect = 6e-38, Method: Composition-based stats. Identities = 49/349 (14%), Positives = 106/349 (30%), Gaps = 97/349 (27%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVK-----LDSKVKIVIKMLK----PVKKKKIKREIK 84 + E +G G + VFQ + + +KMLK + +RE Sbjct: 43 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAA 102 Query: 85 ILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI 144 ++ + N NI+ L + + Sbjct: 103 LMAEFDN---------------------------------------PNIVKLLGVC--AV 121 Query: 145 SKTPALVFEYVDNVDFRILYPKLTDLEIRF---------------------------YMF 177 K L+FEY+ D ++ + Sbjct: 122 GKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIAR 181 Query: 178 ELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVA---SR 234 ++ + Y +HRD+ N ++ +N +++ D+GL+ + Y Sbjct: 182 QVAAGMAYLSERKFVHRDLATRNCLVG-ENMVVKIADFGLSRNIYSADYYKADGNDAIPI 240 Query: 235 FFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFE 294 + PE + Y Y D+W++G +L + ++G ++ + + + + Sbjct: 241 RWMPPESIF-YNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYV--------RD 291 Query: 295 KYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNL 343 +L P E Y++ +R W + D S + ++ + Sbjct: 292 GNILACPENCPLELYNL---MRLCWSKLPADRPSFCSIHR----ILQRM 333 >6FEX-A nrPDB Length = 321 Score = 154 bits (389), Expect = 6e-38, Method: Composition-based stats. Identities = 50/366 (13%), Positives = 117/366 (31%), Gaps = 106/366 (28%) Query: 35 TNTKDYEIENKVGRGKYSEVFQG----------------VKLDSKVKIVIKMLKPVK--- 75 + K+G G++ EV V+ + + +K+L+P Sbjct: 13 FPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKN 72 Query: 76 -KKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANII 134 + +E+KI++ L + NII Sbjct: 73 ARNDFLKEVKIMSRLKD---------------------------------------PNII 93 Query: 135 HLFDIIKDPISKTPALVFEYVDNVDFRILY----------------PKLTDLEIRFYMFE 178 L + ++ +Y++N D P ++ + + Sbjct: 94 RLLGVCVQ--DDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDPTISYPMLLHVAAQ 151 Query: 179 LLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVR---VASRF 235 + + Y ++ +HRD+ N ++ +N +++ D+G++ + Y V+ V Sbjct: 152 IASGMRYLATLNFVHRDLATRNCLVG-ENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIR 210 Query: 236 FKGPELLVDYRMYDYSLDLWSFGTMLAS--MIFKREPFFHGTSNTDQLVKIVKVLGTSDF 293 + E ++ + + D+W+FG L M+ + +PF T ++++ G Sbjct: 211 WMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDE-----QVIENAGEFFR 264 Query: 294 EKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLT 353 ++ Y P + + + + W R + R Sbjct: 265 DQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLH-----------------RFL 307 Query: 354 AKEAMG 359 A++A+ Sbjct: 308 AEDALN 313 >6HV0-A nrPDB Length = 416 Score = 154 bits (388), Expect = 7e-38, Method: Composition-based stats. Identities = 66/350 (18%), Positives = 122/350 (34%), Gaps = 98/350 (28%) Query: 40 YEIENKVGRGKYSE-VFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTT 98 + ++ +G G V++G + + +K + P RE+++L + Sbjct: 10 FCPKDVLGHGAEGTIVYRG--MFDNRDVAVKRILPECFSFADREVQLLRESDE------- 60 Query: 99 LPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF------ 152 H N+I F KD + A+ Sbjct: 61 -------------------------------HPNVIRYFCTEKDRQFQYIAIELCAATLQ 89 Query: 153 EYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR- 211 EYV+ DF L LE + + L + HS+ I+HRD+KPHN++I N + Sbjct: 90 EYVEQKDFAHLG-----LEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKI 144 Query: 212 ---LIDWGLAEFY----HVNMEYNVRVASRFFKGPELLVDYRM--YDYSLDLWSFGTMLA 262 + D+GL + H + + + PE+L + Y++D++S G + Sbjct: 145 KAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFY 204 Query: 263 SMIF-KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 +I PF G S Q ++ + I Sbjct: 205 YVISEGSHPF--GKSLQRQANILLGACSLDCLHPEKHEDVI------------------- 243 Query: 322 FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIE 371 +LI+ ++ D Q+R +AK + HP+F + +Q++ Sbjct: 244 --------------ARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQ 279 >3SXS-A nrPDB Length = 268 Score = 153 bits (387), Expect = 9e-38, Method: Composition-based stats. Identities = 45/319 (14%), Positives = 114/319 (35%), Gaps = 65/319 (20%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK--PVKKKKIKREIKILTDLS 90 ++ + ++G G++ V G K + + +KM+K + + + +E + + LS Sbjct: 3 MELKREEITLLKELGSGQFGVVKLG-KWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLS 61 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPAL 150 H ++ + + + Sbjct: 62 ---------------------------------------HPKLVKFYGVCSK--EYPIYI 80 Query: 151 VFEYVDNVDF----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK 206 V EY+ N R L ++ +++ + + + S +HRD+ N ++D + Sbjct: 81 VTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVD-R 139 Query: 207 NKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLAS 263 + +++ D+G+ + ++ +Y V ++F + PE+ ++ Y D+W+FG ++ Sbjct: 140 DLCVKVSDFGMTRYV-LDDQYVSSVGTKFPVKWSAPEVFHYFK-YSSKSDVWAFGILMWE 197 Query: 264 MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFI 323 + + + +N++ ++K+ + + L Y Q + WH Sbjct: 198 VFSLGKMPYDLYTNSEVVLKV--------SQGHRLYRPHLASDTIY---QIMYSCWHELP 246 Query: 324 NDGNKHLSGNDEIIDLIDN 342 I L + Sbjct: 247 EKRPTFQQLLSSIEPLREK 265 >6CTH-A nrPDB Length = 309 Score = 153 bits (387), Expect = 9e-38, Method: Composition-based stats. Identities = 59/273 (21%), Positives = 105/273 (38%), Gaps = 55/273 (20%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKR---EIKILTDLSNEK 93 T ++ ENK+G G + V++G DS I +K + K+ IK E+KI++ L Sbjct: 14 TSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISRLR--- 70 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 H N++ L + LV+E Sbjct: 71 ------------------------------------HKNLVKLIGWCHERGE--LMLVYE 92 Query: 154 YVDNVDFRILY---PKLTDLEIRF-YMFELLKALDYCHSMG---IMHRDVKPHNVMIDHK 206 ++ N L E+R+ + +L AL Y H G ++HRD+K N+M+D Sbjct: 93 FMANGSLDSHIFKGKSLLTWEVRYRIVKDLASALLYLHEEGDHCVLHRDIKTSNIMLDS- 151 Query: 207 NKKLRLIDWGLAEFYH--VNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASM 264 + +L D+GLA ++ + + + PE L + D++SFG + + Sbjct: 152 SFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSSGKA-SKESDVYSFGVVALEI 210 Query: 265 IFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYL 297 R ++ L+ + V + E+ L Sbjct: 211 ASGRRSIEPKFEESEALLLVPWVWESYGNERIL 243 >1BYG-A nrPDB Length = 278 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 49/310 (15%), Positives = 105/310 (33%), Gaps = 63/310 (20%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVK-KKKIKREIKILTDLSN 91 W+ N K+ ++ +G+G++ +V G K+ +K +K + E ++T L Sbjct: 16 WALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLR- 72 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H+N++ L +I + +V Sbjct: 73 --------------------------------------HSNLVQLLGVIVEEKGG-LYIV 93 Query: 152 FEYVDNVDFRILYPK-----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK 206 EY+ L + + ++ +A++Y +HRD+ NV++ Sbjct: 94 TEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSED 153 Query: 207 NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 N ++ D+GL + + + PE L + + + D+WSFG +L + Sbjct: 154 N-VAKVSDFGLTKEASSTQDTGKL--PVKWTAPEALRE-KKFSTKSDVWSFGILLWEIYS 209 Query: 267 KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG 326 + D + ++ K Y + P Y+ ++ WH Sbjct: 210 FGRVPYPRIPLKDVVPRVEK--------GYKMDAPDGCPPAVYE---VMKNCWHLDAAMR 258 Query: 327 NKHLSGNDEI 336 L +++ Sbjct: 259 PSFLQLREQL 268 >1K9A-A nrPDB Length = 450 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 50/310 (16%), Positives = 105/310 (33%), Gaps = 63/310 (20%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVK-KKKIKREIKILTDLSN 91 W+ N K+ ++ +G+G++ +V G K+ +K +K + E ++T L Sbjct: 188 WALNMKELKLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQAFLAEASVMTQLR- 244 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H+N++ L +I + +V Sbjct: 245 --------------------------------------HSNLVQLLGVIVEEKGG-LYIV 265 Query: 152 FEYVDNVDFRILYPK-----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK 206 EY+ L + + ++ +A++Y +HRD+ NV++ Sbjct: 266 TEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSED 325 Query: 207 NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 N ++ D+GL + + + PE L + + + D+WSFG +L + Sbjct: 326 N-VAKVSDFGLTKEASSTQDTGKL--PVKWTAPEALRE-KKFSTKSDVWSFGILLWEIYS 381 Query: 267 KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG 326 + D + ++ K Y + P YD ++ WH Sbjct: 382 FGRVPYPRIPLKDVVPRVEK--------GYKMDAPDGCPPAVYD---VMKNCWHLDAATR 430 Query: 327 NKHLSGNDEI 336 L +++ Sbjct: 431 PTFLQLREQL 440 >1U54-B nrPDB Length = 291 Score = 153 bits (386), Expect = 1e-37, Method: Composition-based stats. Identities = 57/321 (17%), Positives = 109/321 (33%), Gaps = 63/321 (19%) Query: 31 IDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVK---IVIKMLKPVKKKKIKREIKILT 87 + KD + K+G G + V +G K + +K LKP +L+ Sbjct: 11 LTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPD----------VLS 60 Query: 88 DLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKT 147 + + + H N+I L+ ++ P K Sbjct: 61 Q-----------------------PEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMK- 96 Query: 148 PALVFEYVDNVDFRILYPK----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI 203 +V E K + Y ++ + + Y S +HRD+ N+++ Sbjct: 97 --MVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLL 154 Query: 204 DHKNKKLRLIDWGLAEFYHVNMEYNV----RVASRFFKGPELLVDYRMYDYSLDLWSFGT 259 ++ +++ D+GL N ++ V R + PE L R + ++ D W FG Sbjct: 155 ATRDL-VKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKT-RTFSHASDTWMFGV 212 Query: 260 MLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPW 319 L M + + G + + L KI D E L P++ Y+ + + W Sbjct: 213 TLWEMFTYGQEPWIGLNGSQILHKI-------DKEGERLPRPEDCPQDIYN---VMVQCW 262 Query: 320 HRFINDGNKHLSGNDEIIDLI 340 D ++ + D + Sbjct: 263 AHKPEDRPTFVA----LRDFL 279 >4EUU-A nrPDB Length = 319 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 49/269 (18%), Positives = 100/269 (37%), Gaps = 66/269 (24%) Query: 42 IENKVGRGKYSEVFQGVKLDSKVKIVIKM------LKPVKKKKIKREIKILTDLSNEKVP 95 + + +G+G + VF+G + IK+ L+PV + RE ++L L+ Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLN----- 65 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 H NI+ LF I ++ ++ L+ E+ Sbjct: 66 ----------------------------------HKNIVKLFAIEEETTTRHKVLIMEFC 91 Query: 156 DNVDFRILYPK------LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM--IDHKN 207 + + L + E + +++ +++ GI+HR++KP N+M I Sbjct: 92 PCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDG 151 Query: 208 KKL-RLIDWGLAEFYHVNMEYNVRVASRFFKGPELLV-------DYRMYDYSLDLWSFGT 259 + + +L D+G A + ++ + + P++ + Y ++DLWS G Sbjct: 152 QSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGV 211 Query: 260 MLASMIFKREPFFH---GTSNTDQLVKIV 285 PF N + + KI+ Sbjct: 212 TFYHAATGSLPFRPFEGPRRNKEVMYKII 240 >3C1X-A nrPDB Length = 373 Score = 152 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 55/298 (18%), Positives = 106/298 (35%), Gaps = 55/298 (18%) Query: 41 EIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLP 100 +GRG + V+ G LD+ KKI +K L +++ Sbjct: 92 HFNEVIGRGHFGCVYHGTLLDN------------DGKKIHCAVKSLNRITDIG------- 132 Query: 101 FQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDF 160 +V +F+ I + H N++ L I +P +V Y+ + D Sbjct: 133 ------------EVSQFLTEGIIMKD-FSHPNVLSLLGICLRS-EGSPLVVLPYMKHGDL 178 Query: 161 RILY----PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWG 216 R T ++ + ++ K + + S +HRD+ N M+D K +++ D+G Sbjct: 179 RNFIRNETHNPTVKDLIGFGLQVAKGMKFLASKKFVHRDLAARNCMLDEK-FTVKVADFG 237 Query: 217 LAEFYHVNMEYNV--RVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 LA + +V + ++ + E L + + D+WSFG +L ++ + P Sbjct: 238 LARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQK-FTTKSDVWSFGVLLWELMTRGAPP 296 Query: 272 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 + + D + + L P Y+ + K WH Sbjct: 297 YPDVNTFD--------ITVYLLQGRRLLQPEYCPDPLYE---VMLKCWHPKAEMRPSF 343 >3PLS-A nrPDB Length = 298 Score = 152 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 55/318 (17%), Positives = 112/318 (35%), Gaps = 69/318 (21%) Query: 43 ENKVGRGKYSEVFQGVKLD---SKVKIVIKMLKPV----KKKKIKREIKILTDLSNEKVP 95 + +G+G + V+ G +D ++++ IK L + + + RE ++ L+ Sbjct: 26 DRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLN----- 80 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 H N++ L I+ P P ++ Y+ Sbjct: 81 ----------------------------------HPNVLALIGIML-PPEGLPHVLLPYM 105 Query: 156 DNVDF----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 + D R T ++ + ++ + ++Y +HRD+ N M+D ++ ++ Sbjct: 106 CHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEYLAEQKFVHRDLAARNCMLD-ESFTVK 164 Query: 212 LIDWGLAEFYHVNMEYNVR-----VASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 + D+GLA Y+V+ + E L YR + D+WSFG +L ++ Sbjct: 165 VADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTYR-FTTKSDVWSFGVLLWELLT 223 Query: 267 KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG 326 + P + D L + L P Y Q +++ W Sbjct: 224 RGAPPYRHIDPFD--------LTHFLAQGRRLPQPEYCPDSLY---QVMQQCWEADPAVR 272 Query: 327 NKHLSGNDEIIDLIDNLL 344 E+ ++ LL Sbjct: 273 PTFRVLVGEVEQIVSALL 290 >6BSD-A nrPDB Length = 876 Score = 152 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 50/372 (13%), Positives = 117/372 (31%), Gaps = 112/372 (30%) Query: 35 TNTKDYEIENKVGRGKYSEVFQG----------------VKLDSKVKIVIKMLKPVK--- 75 + K+G G++ EV V+ + + +K+L+P Sbjct: 568 FPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKN 627 Query: 76 -KKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANII 134 + +E+KI++ L + NII Sbjct: 628 ARNDFLKEVKIMSRLKD---------------------------------------PNII 648 Query: 135 HLFDIIKDPISKTPALVFEYVDNVDFRILY----------------------PKLTDLEI 172 L + ++ +Y++N D P ++ + Sbjct: 649 RLLGVCVQ--DDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPML 706 Query: 173 RFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVR-- 230 ++ + Y ++ +HRD+ N ++ +N +++ D+G++ + Y V+ Sbjct: 707 LHVAAQIASGMRYLATLNFVHRDLATRNCLVG-ENFTIKIADFGMSRNLYAGDYYRVQGR 765 Query: 231 -VASRFFKGPELLVDYRMYDYSLDLWSFGTMLAS--MIFKREPFFHGTSNTDQLVKIVKV 287 V + E ++ + + D+W+FG L M+ + +PF T ++++ Sbjct: 766 AVLPIRWMAWECIL-MGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDE-----QVIEN 819 Query: 288 LGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYD 347 G ++ Y P + + + + W R + Sbjct: 820 AGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLH-------------- 865 Query: 348 HQERLTAKEAMG 359 R A++A+ Sbjct: 866 ---RFLAEDALN 874 >3LLT-A nrPDB Length = 360 Score = 151 bits (382), Expect = 3e-37, Method: Composition-based stats. Identities = 67/362 (18%), Positives = 130/362 (35%), Gaps = 75/362 (20%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK--KKIKREIKILTDLSNEKVPPT 97 + + K+G G + V +D+K +K+++ +KK + K E IL + Sbjct: 37 FLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQ---NDDI 93 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 + D + I + L++II Sbjct: 94 NNNNIVKYHGKFMYYDHMCLIFEPLGPS----------LYEIIT---------------- 127 Query: 158 VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH------------ 205 R Y +I+ Y E+LKAL+Y M + H D+KP N+++D Sbjct: 128 ---RNNYNGFHIEDIKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRR 184 Query: 206 ------------KNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLD 253 K+ ++LID+G A F + + +R ++ PE++++ +D S D Sbjct: 185 VTDGKKIQIYRTKSTGIKLIDFGCATFKSD--YHGSIINTRQYRAPEVILNL-GWDVSSD 241 Query: 254 LWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQ 313 +WSFG +LA + F + + L + ++ K +L Y Sbjct: 242 MWSFGCVLAELYTGSL-LFRTHEHMEHLAMMESIIQP--IPKNMLYEATKTNGSKYVNKD 298 Query: 314 YIRKPWHRFINDGNK-----------HLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPW 362 ++ W + N + ++ D + ++L+ D R + E + H + Sbjct: 299 ELKLAWPENASSINSIKHVKKCLPLYKIIKHELFCDFLYSILQIDPTLRPSPAELLKHKF 358 Query: 363 FA 364 Sbjct: 359 LE 360 >5B2L-A nrPDB Length = 324 Score = 151 bits (382), Expect = 4e-37, Method: Composition-based stats. Identities = 47/341 (13%), Positives = 106/341 (31%), Gaps = 81/341 (23%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNE 92 + D E ++G G +V++ + I +K ++ Sbjct: 12 YQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRR------------------- 52 Query: 93 KVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVF 152 + KE+ + + + I+ F + Sbjct: 53 ---------------SGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTD--VFIAM 95 Query: 153 EYVDNVDFRILYPKL----TDLEIRFYMFELLKALDYC-HSMGIMHRDVKPHNVMIDHKN 207 E + L ++ + + ++KAL Y G++HRDVKP N+++D + Sbjct: 96 ELM-GTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLD-ER 153 Query: 208 KKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRM----YDYSLDLWSFGTMLAS 263 +++L D+G++ + + PE + YD D+WS G L Sbjct: 154 GQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVE 213 Query: 264 MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFI 323 + + P+ + ++ + L K++ Sbjct: 214 LATGQFPYKNCKTDFEVLTKVL----------------------------------QEEP 239 Query: 324 NDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFA 364 H+ + + + + L DH++R + + H + Sbjct: 240 PLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIK 280 >2WTK-B nrPDB Length = 373 Score = 151 bits (381), Expect = 4e-37, Method: Composition-based stats. Identities = 57/359 (15%), Positives = 116/359 (32%), Gaps = 65/359 (18%) Query: 40 YEIENKVGRGKYS---EVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPP 96 YE+ +G+G + V + + ++ + Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEAC-------------------- 49 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 +++ F++ + H NI+ +V ++ Sbjct: 50 --------------SNEMVTFLQGELHVSKLFNHPNIVPYRATFI--ADNELWVVTSFMA 93 Query: 157 NVDFRIL-----YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK--- 208 + L + +L I + + +LKALDY H MG +HR VK +++I K Sbjct: 94 YGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYL 153 Query: 209 -----KLRLIDWGLA-EFYHVNMEYNVRVASRFFKGPELL-VDYRMYDYSLDLWSFGTML 261 L +I G H +Y+V+V + PE+L + + YD D++S G Sbjct: 154 SGLRSNLSMISHGQRQRVVHDFPKYSVKV--LPWLSPEVLQQNLQGYDAKSDIYSVGITA 211 Query: 262 ASMIFKREPFFHGTSNTDQLVK-------IVKVLGTSDFEKYLLKYEITLPREFYD-MDQ 313 + PF + L K ++ E + D + Sbjct: 212 CELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTT 271 Query: 314 YIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK 372 +P + H + + ++ L+ + R +A + H +F I+ + + Sbjct: 272 STPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRASE 330 >4EUT-A nrPDB Length = 396 Score = 151 bits (381), Expect = 5e-37, Method: Composition-based stats. Identities = 49/269 (18%), Positives = 100/269 (37%), Gaps = 66/269 (24%) Query: 42 IENKVGRGKYSEVFQGVKLDSKVKIVIKM------LKPVKKKKIKREIKILTDLSNEKVP 95 + + +G+G + VF+G + IK+ L+PV + RE ++L L+ Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLN----- 65 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 H NI+ LF I ++ ++ L+ E+ Sbjct: 66 ----------------------------------HKNIVKLFAIEEETTTRHKVLIMEFC 91 Query: 156 DNVDFRILYPK------LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM--IDHKN 207 + + L + E + +++ +++ GI+HR++KP N+M I Sbjct: 92 PCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDG 151 Query: 208 KKL-RLIDWGLAEFYHVNMEYNVRVASRFFKGPELLV-------DYRMYDYSLDLWSFGT 259 + + +L D+G A + ++ + + P++ + Y ++DLWS G Sbjct: 152 QSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGV 211 Query: 260 MLASMIFKREPFFH---GTSNTDQLVKIV 285 PF N + + KI+ Sbjct: 212 TFYHAATGSLPFRPFEGPRRNKEVMYKII 240 >4JLC-A nrPDB Length = 657 Score = 151 bits (381), Expect = 5e-37, Method: Composition-based stats. Identities = 49/269 (18%), Positives = 100/269 (37%), Gaps = 66/269 (24%) Query: 42 IENKVGRGKYSEVFQGVKLDSKVKIVIKM------LKPVKKKKIKREIKILTDLSNEKVP 95 + + +G+G + VF+G + +K+ L+PV + RE ++L L+ Sbjct: 12 LSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ--MREFEVLKKLN----- 64 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 H NI+ LF I ++ ++ L+ E+ Sbjct: 65 ----------------------------------HKNIVKLFAIEEETTTRHKVLIMEFC 90 Query: 156 DNVDFRILYPK------LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM--IDHKN 207 + + L + E + +++ +++ GI+HRD+KP N+M I Sbjct: 91 PCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDG 150 Query: 208 KKL-RLIDWGLAEFYHVNMEYNVRVASRFFKGPELLV-------DYRMYDYSLDLWSFGT 259 + + +L D+G A + ++ + + P++ + Y ++DLWS G Sbjct: 151 QSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGV 210 Query: 260 MLASMIFKREPFFH---GTSNTDQLVKIV 285 PF N + + KI+ Sbjct: 211 TFYHAATGSLPFRPFEGPRRNKEVMYKII 239 >3BBT-B nrPDB Length = 328 Score = 151 bits (381), Expect = 5e-37, Method: Composition-based stats. Identities = 50/320 (15%), Positives = 100/320 (31%), Gaps = 59/320 (18%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 + + +G G + V++G+ + + KI IKIL + + K Sbjct: 15 TELKRVKVLGSGAFGTVYKGIWVPEGETV-----------KIPVAIKILNETTGPKANV- 62 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 H +++ L + P T LV + + + Sbjct: 63 -------------------EFMDEALIMASMDHPHLVRLLGVCLSP---TIQLVTQLMPH 100 Query: 158 VDFRILYPKLTD----LEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLI 213 + D + + ++ K + Y ++HRD+ NV++ N +++ Sbjct: 101 GCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPN-HVKIT 159 Query: 214 DWGLAEFYHVNM-EYNVRVASRF--FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 D+GLA + EYN + E + YR + + D+WS+G + ++ Sbjct: 160 DFGLARLLEGDEKEYNADGGKMPIKWMALECI-HYRKFTHQSDVWSYGVTIWELMTFGGK 218 Query: 271 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 330 + G + + K P D+ + K W + K Sbjct: 219 PYDGIPTREIPDLLEKGERLPQP-----------PICTIDVYMVMVKCWMIDADSRPKFK 267 Query: 331 SGNDEIIDLIDNLLRYDHQE 350 E + D Q Sbjct: 268 ELAAEF----SRM-ARDPQR 282 >5U6B-A nrPDB Length = 307 Score = 150 bits (379), Expect = 8e-37, Method: Composition-based stats. Identities = 50/343 (14%), Positives = 117/343 (34%), Gaps = 75/343 (21%) Query: 24 WDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKL--DSKVKIVIKMLK-----PVKK 76 + + + D + + +G G++ V +G DS +K+ +K +K + Sbjct: 9 EELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSEL 68 Query: 77 KKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHL 136 + E + + H N++ L Sbjct: 69 EDFLSEAVCMKE---------------------------------------FDHPNVMRL 89 Query: 137 FDII----KDPISKTPALVFEYVDNVDFR--ILYPKLTDLEI-------RFYMFELLKAL 183 + + P ++ ++ + D +LY +L D + +M ++ + Sbjct: 90 IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGM 149 Query: 184 DYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPE 240 +Y + +HRD+ N M++ +N + + D+GL++ + Y ++ + E Sbjct: 150 EYLSTKRFIHRDLAARNCMLN-ENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIE 208 Query: 241 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 300 L D R+Y D+WSFG + + + + + G N++ + LK Sbjct: 209 SLAD-RVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYD--------YLRQGNRLKQ 259 Query: 301 EITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNL 343 Y + + + W D +++ + + L Sbjct: 260 PADCLDGLYAL---MSRCWELNPQDRPSFTELREDLENTLKAL 299 >3QUP-A nrPDB Length = 323 Score = 148 bits (373), Expect = 4e-36, Method: Composition-based stats. Identities = 50/343 (14%), Positives = 114/343 (33%), Gaps = 76/343 (22%) Query: 25 DYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSK---VKIVIKMLKPV-----KK 76 + + + D + + + +G+G++ V + VK+ +KMLK Sbjct: 10 ELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDI 69 Query: 77 KKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHL 136 ++ RE + + H ++ L Sbjct: 70 EEFLREAACMKE---------------------------------------FDHPHVAKL 90 Query: 137 FDIIKDPISKT----PALVFEYVDNVDFRILYP---------KLTDLEIRFYMFELLKAL 183 + +K P ++ ++ + D L + +M ++ + Sbjct: 91 VGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMVDIACGM 150 Query: 184 DYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPE 240 +Y S +HRD+ N M+ ++ + + D+GL+ + Y AS+ + E Sbjct: 151 EYLSSRNFIHRDLAARNCML-AEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALE 209 Query: 241 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 300 L D +Y D+W+FG + ++ + + + G N + ++ LK Sbjct: 210 SLAD-NLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIG--------GNRLKQ 260 Query: 301 EITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNL 343 E YD+ + + W E+ +++ +L Sbjct: 261 PPECMEEVYDL---MYQCWSADPKQRPSFTCLRMELENILGHL 300 >6NT9-A nrPDB Length = 742 Score = 148 bits (373), Expect = 4e-36, Method: Composition-based stats. Identities = 49/269 (18%), Positives = 100/269 (37%), Gaps = 66/269 (24%) Query: 42 IENKVGRGKYSEVFQGVKLDSKVKIVIKM------LKPVKKKKIKREIKILTDLSNEKVP 95 + + +G+G + VF+G + IK+ L+PV + RE ++L L+ Sbjct: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLN----- 63 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 H NI+ LF I ++ ++ L+ E+ Sbjct: 64 ----------------------------------HKNIVKLFAIEEETTTRHKVLIMEFC 89 Query: 156 DNVDFRILYPK------LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM--IDHKN 207 + + L + E + +++ +++ GI+HR++KP N+M I Sbjct: 90 PCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDG 149 Query: 208 KKL-RLIDWGLAEFYHVNMEYNVRVASRFFKGPELLV-------DYRMYDYSLDLWSFGT 259 + + +L D+G A + ++ + + P++ + Y ++DLWS G Sbjct: 150 QSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGV 209 Query: 260 MLASMIFKREPFFH---GTSNTDQLVKIV 285 PF N + + KI+ Sbjct: 210 TFYHAATGSLPFRPFEGPRRNKEVMYKII 238 >6O8B-A nrPDB Length = 665 Score = 148 bits (373), Expect = 5e-36, Method: Composition-based stats. Identities = 49/269 (18%), Positives = 100/269 (37%), Gaps = 66/269 (24%) Query: 42 IENKVGRGKYSEVFQGVKLDSKVKIVIKM------LKPVKKKKIKREIKILTDLSNEKVP 95 + + +G+G + VF+G + IK+ L+PV + RE ++L L+ Sbjct: 19 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ--MREFEVLKKLN----- 71 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 H NI+ LF I ++ ++ L+ E+ Sbjct: 72 ----------------------------------HKNIVKLFAIEEETTTRHKVLIMEFC 97 Query: 156 DNVDFRILYPK------LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM--IDHKN 207 + + L + E + +++ +++ GI+HR++KP N+M I Sbjct: 98 PCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDG 157 Query: 208 KKL-RLIDWGLAEFYHVNMEYNVRVASRFFKGPELLV-------DYRMYDYSLDLWSFGT 259 + + +L D+G A + ++ + + P++ + Y ++DLWS G Sbjct: 158 QSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSIGV 217 Query: 260 MLASMIFKREPFFH---GTSNTDQLVKIV 285 PF N + + KI+ Sbjct: 218 TFYHAATGSLPFRPFEGPRRNKEVMYKII 246 >2A1A-B nrPDB Length = 284 Score = 147 bits (372), Expect = 5e-36, Method: Composition-based stats. Identities = 53/301 (17%), Positives = 107/301 (35%), Gaps = 36/301 (11%) Query: 39 DYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTT 98 D++ +G G + +VF+ VIK +K +K +RE+K L L + + Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVK-YNNEKAEREVKALAKLDHVNIVHYN 70 Query: 99 LPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNV 158 + Y +K + E+ D Sbjct: 71 GCWDGFDYDPETSSKNSS-------------------------RSKTKCLFIQMEFCDKG 105 Query: 159 DF-----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLI 213 + KL + ++ K +DY HS +++RD+KP N+ + K++++ Sbjct: 106 TLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFL-VDTKQVKIG 164 Query: 214 DWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI-FKREPFF 272 D+GL + + + + PE + + Y +DL++ G +LA ++ F Sbjct: 165 DFGLVTSLKNDGKRTRSKGTLRYMSPEQI-SSQDYGKEVDLYALGLILAELLHVCDTAFE 223 Query: 273 HGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKP--WHRFINDGNKHL 330 TD I+ + + L K P + + + +R W + +H Sbjct: 224 TSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEKNERHT 283 Query: 331 S 331 + Sbjct: 284 A 284 >3I81-A nrPDB Length = 315 Score = 147 bits (372), Expect = 6e-36, Method: Composition-based stats. Identities = 49/333 (14%), Positives = 112/333 (33%), Gaps = 81/333 (24%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGV-----KLDSKVKIVIKMLKPV----KKKKIKRE 82 +W + + ++G+G + V++GV K + + ++ IK + ++ + E Sbjct: 12 EWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNE 71 Query: 83 IKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD 142 ++ + N H +++ L ++ Sbjct: 72 ASVMKE--------------------------------------FNCH-HVVRLLGVVSQ 92 Query: 143 PISKTPALVFEYVDNVDFRILYPKLTDL-------------EIRFYMFELLKALDYCHSM 189 + ++ E + D + L ++ E+ + Y ++ Sbjct: 93 --GQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNAN 150 Query: 190 GIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVA----SRFFKGPELLVDY 245 +HRD+ N M+ ++ +++ D+G+ + +Y + + PE L D Sbjct: 151 KFVHRDLAARNCMV-AEDFTVKIGDFGMTRDIYE-TDYYRKGGKGLLPVRWMSPESLKD- 207 Query: 246 RMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLP 305 ++ D+WSFG +L + E + G SN L ++ E LL P Sbjct: 208 GVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVM--------EGGLLDKPDNCP 259 Query: 306 REFYDMDQYIRKPWHRFINDGNKHLSGNDEIID 338 +++ +R W L I + Sbjct: 260 DMLFEL---MRMCWQYNPKMRPSFLEIISSIKE 289 >4IDT-A nrPDB Length = 356 Score = 147 bits (371), Expect = 6e-36, Method: Composition-based stats. Identities = 47/272 (17%), Positives = 90/272 (33%), Gaps = 65/272 (23%) Query: 24 WDYENTVIDWSTNTKDYEIENK---------VGRGKYSEVFQGVKLDSKVKIVIKMLKPV 74 D E ++ DYE + +GRG + EV + + + +K ++ Sbjct: 51 EDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDKQTGFQCAVKKVR-- 108 Query: 75 KKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANII 134 + + E + I+ Sbjct: 109 -LEVFRAE--------------------------------------ELMACAGLTSPRIV 129 Query: 135 HLFDIIKDPISKTPALVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGI 191 L+ +++ + E ++ L + L + +Y+ + L+ L+Y HS I Sbjct: 130 PLYGAVRE--GPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRI 187 Query: 192 MHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRV------ASRFFKGPELLVDY 245 +H DVK NV++ L D+G A + + + PE+++ Sbjct: 188 LHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLG- 246 Query: 246 RMYDYSLDLWSFGTMLASMIFKREP---FFHG 274 R D +D+WS M+ M+ P FF G Sbjct: 247 RSCDAKVDVWSSCCMMLHMLNGCHPWTQFFRG 278 >3PP0-A nrPDB Length = 338 Score = 145 bits (366), Expect = 3e-35, Method: Composition-based stats. Identities = 46/321 (14%), Positives = 99/321 (30%), Gaps = 61/321 (19%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKV----KIVIKMLKPVKKKKIKREIKILTDLSNEK 93 + +G G + V++G+ + + IK+L+ K +EI Sbjct: 17 TELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEI---------- 66 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 + G + L I + + Sbjct: 67 -------------------------LDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMP 101 Query: 154 YVDNVDF-RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRL 212 Y +D R +L ++ + ++ K + Y + ++HRD+ NV++ N +++ Sbjct: 102 YGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPN-HVKI 160 Query: 213 IDWGLAEFYHVNM-EYNVRVASRF--FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 D+GLA ++ EY+ + E ++ R + + D+WS+G + ++ Sbjct: 161 TDFGLARLLDIDETEYHADGGKVPIKWMALESIL-RRRFTHQSDVWSYGVTVWELMTFGA 219 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 + G + + K P D+ + K W + Sbjct: 220 KPYDGIPAREIPDLLEKGERLPQP-----------PICTIDVYMIMVKCWMIDSECRPRF 268 Query: 330 LSGNDEIIDLIDNLLRYDHQE 350 E + D Q Sbjct: 269 RELVSEF----SRM-ARDPQR 284 >6FER-A nrPDB Length = 309 Score = 145 bits (365), Expect = 3e-35, Method: Composition-based stats. Identities = 49/334 (14%), Positives = 108/334 (32%), Gaps = 86/334 (25%) Query: 34 STNTKDYEIENKVGRGKYSEVFQG--------------VKLDSKVKI--VIKMLKPVK-- 75 K + K+G G++ EV + + + + +KML+ Sbjct: 5 EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANK 64 Query: 76 --KKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANI 133 + +EIKI++ L + NI Sbjct: 65 NARNDFLKEIKIMSRLKD---------------------------------------PNI 85 Query: 134 IHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLE-------------IRFYMFELL 180 IHL + ++ EY++N D + ++F ++ Sbjct: 86 IHLLAVCI--TDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIA 143 Query: 181 KALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVR---VASRFFK 237 + Y S+ +HRD+ N ++ KN +++ D+G++ + Y ++ V + Sbjct: 144 SGMKYLSSLNFVHRDLATRNCLVG-KNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWM 202 Query: 238 GPELLVDYRMYDYSLDLWSFGTMLAS--MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEK 295 E ++ + + D+W+FG L + +P+ + +Q+++ + Sbjct: 203 SWESIL-LGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSD--EQVIENTGEFFRDQGRQ 259 Query: 296 YLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 L P Y + + W R + Sbjct: 260 TYLPQPAICPDSVYKL---MLSCWRRDTKNRPSF 290 >4G3E-A nrPDB Length = 352 Score = 144 bits (364), Expect = 5e-35, Method: Composition-based stats. Identities = 46/283 (16%), Positives = 94/283 (33%), Gaps = 66/283 (23%) Query: 13 TNINKQRTEEYWDYENTVIDWSTNTKDYEIENKV---------GRGKYSEVFQGVKLDSK 63 + + E D E ++ DYE +V GRG + EV + + Sbjct: 41 AKLQRLGPET-EDNEGVLLTEKLKPVDYEYREEVHWMTHQPRVGRGSFGEVHRMKDKQTG 99 Query: 64 VKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIF 123 + +K ++ + + E + Sbjct: 100 FQCAVKKVR---LEVFRVE--------------------------------------ELV 118 Query: 124 DQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK---LTDLEIRFYMFELL 180 I+ L+ +++ + E ++ L + L + +Y+ + L Sbjct: 119 ACAGLSSPRIVPLYGAVRE--GPWVNIFMELLEGGSLGQLIKQMGCLPEDRALYYLGQAL 176 Query: 181 KALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRV------ASR 234 + L+Y H+ I+H DVK NV++ + L D+G A + + + Sbjct: 177 EGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTE 236 Query: 235 FFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP---FFHG 274 PE+++ + D +D+WS M+ M+ P +F G Sbjct: 237 THMAPEVVMG-KPCDAKVDIWSSCCMMLHMLNGCHPWTQYFRG 278 >4Y83-A nrPDB Length = 332 Score = 144 bits (363), Expect = 5e-35, Method: Composition-based stats. Identities = 59/358 (16%), Positives = 119/358 (33%), Gaps = 82/358 (22%) Query: 15 INKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPV 74 I Q D + +I W ++ + + RG + +V+ + +K ++ K++ Sbjct: 51 ITPQNGRYQIDSDVLLIPWKLTYRNIG-SDFIPRGAFGKVYLAQDIKTKKRMACKLIPVD 109 Query: 75 KKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANII 134 + K EI+ H NI Sbjct: 110 QFKPSDVEIQAC-----------------------------------------FRHENIA 128 Query: 135 HLFDIIKDPISKTPALVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGI 191 L+ + +T L E + + + EI + +LK LD+ HS + Sbjct: 129 ELYGAVL--WGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKV 186 Query: 192 MHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEY-NVRVASRFFKGPELLVDYRMYDY 250 +H D+KP N++ + K L+D+GL+ ++ + + + PE+++ R + Sbjct: 187 IHHDIKPSNIVF--MSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL-CRGHST 243 Query: 251 SLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYD 310 D++S G L M P ++ +Y + + Sbjct: 244 KADIYSLGATLIHMQTGTPP-------------------------WVKRYPRSAYPSYLY 278 Query: 311 MDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIRE 368 + P +D + + +LI+ L + R A + + H P RE Sbjct: 279 IIHKQAPPLEDIADD------CSPGMRELIEASLERNPNHRPRAADLLKHEALNPPRE 330 >5HVK-A nrPDB Length = 315 Score = 144 bits (363), Expect = 6e-35, Method: Composition-based stats. Identities = 59/357 (16%), Positives = 116/357 (32%), Gaps = 106/357 (29%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK---IKREIKILTDLSN 91 D +G+G + + + ++ +V+K L ++ +E+K++ L Sbjct: 11 FRPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLE- 69 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 H N++ ++ K + Sbjct: 70 --------------------------------------HPNVLKFIGVLYK--DKRLNFI 89 Query: 152 FEYVDNVDFRILYPKLTDL----EIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN 207 EY+ R + + + + ++ + Y HSM I+HR++ HN ++ +N Sbjct: 90 TEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRNLNSHNCLV-REN 148 Query: 208 KKLRLIDWGLAEFY---------------HVNMEYNVRVASRFFKGPELLVDYRMYDYSL 252 K + + D+GLA + V + ++ PE++ + R YD + Sbjct: 149 KNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMI-NGRSYDEKV 207 Query: 253 DLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMD 312 D++SFG +L +I G N D LPR D Sbjct: 208 DVFSFGIVLCEII--------GRVNAD---------------------PDYLPRTM-DFG 237 Query: 313 QYIRKPWHRF--INDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIR 367 +R R+ N DL D ++R + + + H W +R Sbjct: 238 LNVRGFLDRYCPPNCPPSFFPITVRCCDL-------DPEKRPSFVK-LEH-WLETLR 285 >5U6C-A nrPDB Length = 315 Score = 144 bits (362), Expect = 7e-35, Method: Composition-based stats. Identities = 47/343 (13%), Positives = 113/343 (32%), Gaps = 75/343 (21%) Query: 24 WDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLD---SKVKIVIKMLKPV-----K 75 + +N + D + + +G G++ V +G + +K+ +K +K + Sbjct: 22 EELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQRE 81 Query: 76 KKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIH 135 ++ E + D H N++ Sbjct: 82 IEEFLSEAACMKD---------------------------------------FSHPNVMR 102 Query: 136 LFDIIKDPISK---TPALVFEYVDNVDFRILY---------PKLTDLEIRFYMFELLKAL 183 L + + S+ P ++ ++ D + + +M ++ + Sbjct: 103 LLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGM 162 Query: 184 DYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPE 240 +Y + +HRD+ N M+ + + + D+GL++ + Y ++ + E Sbjct: 163 EYLSNRNFLHRDLAARNCML-RDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIE 221 Query: 241 LLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKY 300 L D R+Y D+W+FG + + + + G N + + + LK Sbjct: 222 SLAD-RVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHE--------MYDYLLHGHRLKQ 272 Query: 301 EITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNL 343 E Y++ + W D ++ L+++L Sbjct: 273 PEDCLDELYEI---MYSCWRTDPLDRPTFSVLRLQLEKLLESL 312 >4YFF-A nrPDB Length = 311 Score = 144 bits (362), Expect = 8e-35, Method: Composition-based stats. Identities = 44/299 (14%), Positives = 95/299 (31%), Gaps = 57/299 (19%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK------PVKKKKIKREIKIL 86 + + E +G G + +V++G + IK + RE+ IL Sbjct: 37 FHLQLSEIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDMFCREVSIL 94 Query: 87 TDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISK 146 L+ H +I + S+ Sbjct: 95 CQLN---------------------------------------HPCVIQFVGACLNDPSQ 115 Query: 147 TPALVFEYVDNVDFRILY---PKLTDLEIRFYMF-ELLKALDYCHS--MGIMHRDVKPHN 200 A+V +Y+ L ++ DL+ + + ++ K ++Y H+ I+HRD+ HN Sbjct: 116 -FAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHN 174 Query: 201 VMIDHKNKKLRLIDWGLAEFYH--VNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFG 258 +++ +++ + D+G + F + + + PE+ Y D++S+ Sbjct: 175 ILL-YEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFTQCTRYTIKADVFSYA 233 Query: 259 TMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRK 317 L ++ PF H + L R + + + Sbjct: 234 LCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPE 292 >3QD2-B nrPDB Length = 332 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 47/268 (17%), Positives = 103/268 (38%), Gaps = 41/268 (15%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK----PVKKKKIKREIKILTDLSNEK 93 D+E +GRG + VF+ IK ++ + ++K+ RE+K L L + Sbjct: 6 TDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPG 65 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGH-----ANI-IHLFDIIK------ 141 + + + Q+E +++ D P + ++ I D Sbjct: 66 IVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVG 125 Query: 142 ----DPISKTPALVFEYVDNVDFRILYPKLTDLEIR------FYMFELLKALDYCHSMGI 191 + + + + + LE R ++ +A+++ HS G+ Sbjct: 126 QLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGL 185 Query: 192 MHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME-------------YNVRVASRFFKG 238 MHRD+KP N+ + +++ D+GL + E + +V ++ + Sbjct: 186 MHRDLKPSNIFFTMDD-VVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMS 244 Query: 239 PELLVDYRMYDYSLDLWSFGTMLASMIF 266 PE + Y + +D++S G +L +++ Sbjct: 245 PEQIHGNN-YSHKVDIFSLGLILFELLY 271 >3LZB-A nrPDB Length = 327 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 49/321 (15%), Positives = 106/321 (33%), Gaps = 61/321 (19%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKI----VIKMLKPVKKKKIKREIKILTDLSNEK 93 +++ +G G + V++G+ + K+ IK L+ K +EI Sbjct: 15 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEI---------- 64 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 Y+ N H + L I + + Sbjct: 65 -----------------------LDEAYVMASVDNPH--VCRLLGICLTSTVQLITQLMP 99 Query: 154 YVDNVDF-RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRL 212 + +D+ R + + + ++ K ++Y ++HRD+ NV++ + +++ Sbjct: 100 FGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTP-QHVKI 158 Query: 213 IDWGLAEFYH-VNMEYNVRVASRF--FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 D+GLA+ EY+ + E ++ +R+Y + D+WS+G + ++ Sbjct: 159 TDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGS 217 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 + G ++ + K P D+ +RK W + K Sbjct: 218 KPYDGIPASEISSILEKGERLPQP-----------PICTIDVYMIMRKCWMIDADSRPKF 266 Query: 330 LSGNDEIIDLIDNLLRYDHQE 350 E + D Q Sbjct: 267 RELIIEF----SKM-ARDPQR 282 >4LRM-A nrPDB Length = 334 Score = 143 bits (360), Expect = 1e-34, Method: Composition-based stats. Identities = 48/322 (14%), Positives = 107/322 (33%), Gaps = 60/322 (18%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKI----VIKMLKPVKKKKIKREIKILTDLSNEK 93 +++ +G G + V++G+ + K+ IK L+ K +EI Sbjct: 19 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEI---------- 68 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHN-GHANIIHLFDIIKDPISKTPALVF 152 Y+ N G+ ++ L I + + Sbjct: 69 -----------------------LDEAYVMASVDNPGNPHVCRLLGICLTSTVQLITQLM 105 Query: 153 EYVDNVDF-RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 + +D+ R + + + ++ K ++Y ++HRD+ NV++ + ++ Sbjct: 106 PFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTP-QHVK 164 Query: 212 LIDWGLAEFYH-VNMEYNVRVASRF--FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 268 + D+GLA+ EY+ + E ++ +R+Y + D+WS+G + ++ Sbjct: 165 ITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFG 223 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 + G ++ + K P D+ + K W + K Sbjct: 224 SKPYDGIPASEISSILEKGERLPQP-----------PICTIDVYMIMVKCWMIDADSRPK 272 Query: 329 HLSGNDEIIDLIDNLLRYDHQE 350 E + D Q Sbjct: 273 FRELIIEF----SKM-ARDPQR 289 >5L2Q-C nrPDB Length = 320 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 45/315 (14%), Positives = 110/315 (34%), Gaps = 50/315 (15%) Query: 55 FQGVKLDSKVKIVIKMLKPVKK------KKIKREIKILTDLSNEKVPPTTLPFQKDQYYT 108 K + +K+L ++ + +R+ K+L + ++ Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 109 NQKEDVLKFIRP-YIFDQPHNGHANIIHLFDII--KDPISKTPALVFEYVDNVDFRILYP 165 ++ + + I + D + D KT L+ + + I Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLI----NLQHYVIKEK 148 Query: 166 KLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFY-HVN 224 +L++ E +++++ ++ H I+HRD+K N++++ + ++ + ++ L + Sbjct: 149 RLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEG 208 Query: 225 MEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKI 284 + S + P++L D+W+ G +L +M++ + PF+ + KI Sbjct: 209 DLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSI-PQELFRKI 267 Query: 285 VKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLL 344 T + + ++ + LI LL Sbjct: 268 KAAEYTIPEDGRV-----------------------------------SENTVCLIRKLL 292 Query: 345 RYDHQERLTAKEAMG 359 D Q+RL A + + Sbjct: 293 VLDPQQRLAAADVLE 307 >4M7I-A nrPDB Length = 299 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 45/281 (16%), Positives = 98/281 (34%), Gaps = 57/281 (20%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML----KPVKKKKIKREIKILTDLSNEK 93 D+E +GRG + VF+ IK + + + ++K+ RE+K L L + Sbjct: 5 TDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPG 64 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 + + + + K + + Sbjct: 65 IVRYFNAWLEKNTTEKLQPSSPKV-----------------------------YLYIQMQ 95 Query: 154 YVDNVDFRILYPKLTDLEIR------FYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN 207 + + +E R ++ +A+++ HS G+MHRD+KP N+ + Sbjct: 96 LCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDD 155 Query: 208 KKLRLIDWGLAEFYHVNME-------------YNVRVASRFFKGPELLVDYRMYDYSLDL 254 +++ D+GL + E + +V ++ + PE + Y + +D+ Sbjct: 156 -VVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNS-YSHKVDI 213 Query: 255 WSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEK 295 +S G +L +++ PF L + + F + Sbjct: 214 FSLGLILFELLY---PFSTQMERVRTLTDVRNLKFPPLFTQ 251 >6B2Q-A nrPDB Length = 317 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 39/240 (16%), Positives = 89/240 (37%), Gaps = 43/240 (17%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 Y ++ + G +V++ V ++ +K+LK Sbjct: 34 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSE------------------------- 68 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI---SKTPALVFEYVD 156 + + ++ R H I + D + + +T LV E V+ Sbjct: 69 --------FSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVN 120 Query: 157 NVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLI 213 + + L+ + + +AL H+ G++HRDVKP N++I ++++ Sbjct: 121 GEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILIT-PTGQVKIT 179 Query: 214 DWGLAEFYH--VNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 D+G+A+ + + + + + PE + + + D++S G + + + PF Sbjct: 180 DFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDA-SPASDVYSLGVVGYEAVSGKRPF 238 >4X3F-A nrPDB Length = 337 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 39/240 (16%), Positives = 89/240 (37%), Gaps = 43/240 (17%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 Y ++ + G +V++ V ++ +K+LK Sbjct: 14 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSE------------------------- 48 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI---SKTPALVFEYVD 156 + + ++ R H I + D + + +T LV E V+ Sbjct: 49 --------FSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVN 100 Query: 157 NVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLI 213 + + L+ + + +AL H+ G++HRDVKP N++I ++++ Sbjct: 101 GEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILIT-PTGQVKIT 159 Query: 214 DWGLAEFYH--VNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 D+G+A+ + + + + + PE + + + D++S G + + + PF Sbjct: 160 DFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDA-SPASDVYSLGVVGYEAVSGKRPF 218 >4OW8-A nrPDB Length = 283 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 39/240 (16%), Positives = 89/240 (37%), Gaps = 43/240 (17%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 Y ++ + G +V++ V ++ +K+LK Sbjct: 13 YRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSE------------------------- 47 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI---SKTPALVFEYVD 156 + + ++ R H I + D + + +T LV E V+ Sbjct: 48 --------FSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVN 99 Query: 157 NVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLI 213 + + L+ + + +AL H+ G++HRDVKP N++I ++++ Sbjct: 100 GEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILIT-PTGQVKIT 158 Query: 214 DWGLAEFYH--VNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 D+G+A+ + + + + + PE + + + D++S G + + + PF Sbjct: 159 DFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDA-SPASDVYSLGVVGYEAVSGKRPF 217 >5UIU-A nrPDB Length = 323 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 46/273 (16%), Positives = 95/273 (34%), Gaps = 63/273 (23%) Query: 14 NINKQRTEEYWDYENTVIDWSTNTKDYEIE-NKVGRGKYSEVFQGVKLDSKVKIVIKMLK 72 ++ R + YE + + + + + NK+G G + V++G + + +K L Sbjct: 22 EVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGY--VNNTTVAVKKLA 79 Query: 73 PV-------KKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQ 125 + K++ +EIK++ Sbjct: 80 AMVDITTEELKQQFDQEIKVMAKCQ----------------------------------- 104 Query: 126 PHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLT-----DLEIRFYMFE-L 179 H N++ L D LV+ Y+ N L +R + + Sbjct: 105 ----HENLVELLGFSSD--GDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGA 158 Query: 180 LKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAE---FYHVNMEYNVRVASRFF 236 +++ H +HRD+K N+++D + ++ D+GLA + + + V + + Sbjct: 159 ANGINFLHENHHIHRDIKSANILLD-EAFTAKISDFGLARASEKFAQTVMTSRIVGTTAY 217 Query: 237 KGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 PE L D++SFG +L +I Sbjct: 218 MAPEALRGE--ITPKSDIYSFGVVLLEIITGLP 248 >1U59-A nrPDB Length = 287 Score = 141 bits (356), Expect = 4e-34, Method: Composition-based stats. Identities = 46/301 (15%), Positives = 104/301 (34%), Gaps = 69/301 (22%) Query: 45 KVGRGKYSEVFQGVKL--DSKVKIVIKMLK----PVKKKKIKREIKILTDLSNEKVPPTT 98 ++G G + V QGV ++ + IK+LK +++ RE +I+ L N Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN------- 69 Query: 99 LPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNV 158 I+ L + + ++ LV E Sbjct: 70 --------------------------------PYIVRLIGVCQ---AEALMLVMEMAGGG 94 Query: 159 DFRIL----YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLID 214 ++ + + ++ + Y +HRD+ NV++ +++ ++ D Sbjct: 95 PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYA-KISD 153 Query: 215 WGLAEFYH-VNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 +GL++ + Y R A ++ + PE + ++R + D+WS+G + + + Sbjct: 154 FGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKFSSRSDVWSYGVTMWEALSYGQK 212 Query: 271 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 330 + + + I + ++ P E Y + + W D L Sbjct: 213 PYKKMKGPEVMAFI--------EQGKRMECPPECPPELYAL---MSDCWIYKWEDRPDFL 261 Query: 331 S 331 + Sbjct: 262 T 262 >5GNK-A nrPDB Length = 297 Score = 141 bits (355), Expect = 5e-34, Method: Composition-based stats. Identities = 48/321 (14%), Positives = 105/321 (32%), Gaps = 61/321 (19%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKI----VIKMLKPVKKKKIKREIKILTDLSNEK 93 +++ +G G + V++G+ + K+ IK L+ K +EI Sbjct: 19 TEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEI---------- 68 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 Y+ N H + L I + + Sbjct: 69 -----------------------LDEAYVMASVDNPH--VCRLLGICLTSTVQLIMQLMP 103 Query: 154 YVDNVDF-RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRL 212 + +D+ R + + + ++ K ++Y ++HRD+ NV++ + +++ Sbjct: 104 FGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTP-QHVKI 162 Query: 213 IDWGLAEFYH-VNMEYNVRVASRF--FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 D+GLA+ EY+ + E ++ +R+Y + D+WS+G + ++ Sbjct: 163 TDFGLAKLLGAEEKEYHAEGGKVPIKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGS 221 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 + G ++ + K P D+ + K W + K Sbjct: 222 KPYDGIPASEISSILEKGERLPQP-----------PICTIDVYMIMVKCWMIDADSRPKF 270 Query: 330 LSGNDEIIDLIDNLLRYDHQE 350 E + D Q Sbjct: 271 RELIIEF----SKM-ARDPQR 286 >2OZO-A nrPDB Length = 613 Score = 140 bits (353), Expect = 8e-34, Method: Composition-based stats. Identities = 45/301 (14%), Positives = 104/301 (34%), Gaps = 69/301 (22%) Query: 45 KVGRGKYSEVFQGVKL--DSKVKIVIKMLK----PVKKKKIKREIKILTDLSNEKVPPTT 98 ++G G + V QGV ++ + IK+LK +++ RE +I+ L N Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDN------- 395 Query: 99 LPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNV 158 I+ L + + ++ LV E Sbjct: 396 --------------------------------PYIVRLIGVCQ---AEALMLVMEMAGGG 420 Query: 159 DFRIL----YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLID 214 ++ + + ++ + Y +HR++ NV++ +++ ++ D Sbjct: 421 PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRNLAARNVLLVNRHYA-KISD 479 Query: 215 WGLAEFYH-VNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREP 270 +GL++ + Y R A ++ + PE + ++R + D+WS+G + + + Sbjct: 480 FGLSKALGADDSYYTARSAGKWPLKWYAPECI-NFRKFSSRSDVWSYGVTMWEALSYGQK 538 Query: 271 FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHL 330 + + + I + ++ P E Y + + W D L Sbjct: 539 PYKKMKGPEVMAFI--------EQGKRMECPPECPPELYAL---MSDCWIYKWEDRPDFL 587 Query: 331 S 331 + Sbjct: 588 T 588 >4F0G-A nrPDB Length = 287 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 54/316 (17%), Positives = 109/316 (34%), Gaps = 61/316 (19%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 + E E ++G+G + V +G + K + IK L Sbjct: 19 NEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSL-------------------------- 52 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 D + + + + +F + H NI+ L+ ++ +P P +V E+V Sbjct: 53 ---ILGDSEGETEMIEKFQEFQREVFIMSNLNHPNIVKLYGLMHNP----PRMVMEFVPC 105 Query: 158 VDFRILYPKLTDLE-------IRFYMFELLKALDYCHSMG--IMHRDVKPHNVMIDH--K 206 D Y +L D M ++ ++Y + I+HRD++ N+ + + Sbjct: 106 GDL---YHRLLDKAHPIKWSVKLRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDE 162 Query: 207 NKKL--RLIDWGLAEFYHVNMEYNVRVASRFFKGPELL-VDYRMYDYSLDLWSFGTMLAS 263 N + ++ D+GL++ + + + + PE + + Y D +SF +L + Sbjct: 163 NAPVCAKVADFGLSQ--QSVHSVSGLLGNFQWMAPETIGAEEESYTEKADTYSFAMILYT 220 Query: 264 MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFI 323 ++ PF + KI K + E P + I W Sbjct: 221 ILTGEGPF-----DEYSYGKI-KFINMIREEGLRPTIPEDCPPR---LRNVIELCWSGDP 271 Query: 324 NDGNKHLSGNDEIIDL 339 E+ +L Sbjct: 272 KKRPHFSYIVKELSEL 287 >4C59-A nrPDB Length = 340 Score = 138 bits (348), Expect = 4e-33, Method: Composition-based stats. Identities = 53/349 (15%), Positives = 111/349 (31%), Gaps = 110/349 (31%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK---IKREIKILTDLSNEKVPP 96 + + G ++ V++ + S + +K L +++K I +E+ + LS Sbjct: 29 LRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLS------ 82 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHL-----FDIIKDPISKTPALV 151 GH NI+ + + L+ Sbjct: 83 --------------------------------GHPNIVQFCSAASIGKEESDTGQAEFLL 110 Query: 152 FEYVDNVDFRILYPK------LTDLEIRFYMFELLKALDYCHSMG--IMHRDVKPHNVMI 203 + K L+ + ++ +A+ + H I+HRD+K N+++ Sbjct: 111 LTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLL 170 Query: 204 DHKNKKLRLIDWGLAEFYHVNMEYN-------------VRVASRFFKGPELLVDYRMY-- 248 ++ ++L D+G A +Y+ R + ++ PE++ Y + Sbjct: 171 SNQG-TIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPI 229 Query: 249 DYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREF 308 D+W+ G +L + F++ PF G K+ V G Sbjct: 230 GEKQDIWALGCILYLLCFRQHPFEDG-------AKLRIVNGKYSI--------------- 267 Query: 309 YDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEA 357 H + LI +L+ + +ERL+ E Sbjct: 268 ------------------PPHDTQYTVFHSLIRAMLQVNPEERLSIAEV 298 >5WNL-A nrPDB Length = 342 Score = 138 bits (347), Expect = 4e-33, Method: Composition-based stats. Identities = 51/313 (16%), Positives = 122/313 (38%), Gaps = 63/313 (20%) Query: 44 NKVGRGKYSEVFQGVKLDSKVKIVIK-----MLKPVKKKKIKREIKILTDLSNEKVPPTT 98 KVG G + +V++ + K + IK + ++ ++ E K + Sbjct: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRY----- 80 Query: 99 LPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNV 158 I+ ++ I ++P+ LV EY++ Sbjct: 81 ----------------------------------ILPVYGICQEPVG----LVMEYMETG 102 Query: 159 DF-RILYPKLTDLEIRF-YMFELLKALDYCHSMG--IMHRDVKPHNVMIDHKNKKLRLID 214 ++L + ++RF + E +++ H M ++H ++KP N+++D + +++ D Sbjct: 103 SLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSPPLLHLNLKPANILLDA-HYHVKISD 161 Query: 215 WGLAEF----YHVNMEYNVRVASRFFKGPELLVD-YRMYDYSLDLWSFGTMLASMIFKRE 269 +GLA+ + ++ + + + PE + + R++D D++SF ++ ++ +++ Sbjct: 162 FGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKK 221 Query: 270 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 PF + ++K+VK + PR + +++ WH Sbjct: 222 PFADEKNILHIMMKVVKGHRPELPPICRPR-----PRACASLIGLMQRCWHADPQVRPTF 276 Query: 330 LSGNDEIIDLIDN 342 E DL + Sbjct: 277 QEITSETEDLCEK 289 >4NEU-A nrPDB Length = 333 Score = 137 bits (344), Expect = 9e-33, Method: Composition-based stats. Identities = 52/342 (15%), Positives = 118/342 (34%), Gaps = 73/342 (21%) Query: 25 DYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK----KKIK 80 + ++ + D+ ++ G + +V + I+ + K + + Sbjct: 11 QPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALL 70 Query: 81 REIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII 140 E K++ L H+ ++ L +I Sbjct: 71 EEAKMMNRLR---------------------------------------HSRVVKLLGVI 91 Query: 141 KDPISKTPALVFEYVDNVDFRILYPKL--TDLEIR-FYMFELLKALDYCHSMGIMHRDVK 197 + + LV EY++ + + T L ++ + E+++ + Y H G++H+D+K Sbjct: 92 IEEGKYS--LVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLK 149 Query: 198 PHNVMIDHKNKKLRLIDWGLA--------------EFYHVNMEYNVRVASRFFKGPELLV 243 P N+++D+ + +++ D GLA E V+ + ++ PE L Sbjct: 150 PENILVDN-DFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLN 208 Query: 244 DYR-MYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEI 302 D D++SF +L ++ +EP+ + QL+ +K D + Sbjct: 209 DVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQ-QLIMCIKSGNRPDVDDI----TE 263 Query: 303 TLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDL-IDNL 343 PRE + ++ W ++ + L Sbjct: 264 YCPREIISL---MKLCWEANPEARPTFPGIEEKFRPFYLSQL 302 >3AOX-A nrPDB Length = 344 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 47/323 (14%), Positives = 98/323 (30%), Gaps = 69/323 (21%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGV-----KLDSKVKIVIKMLKPVKKKKIKREIKILTD 88 K+ + +G G + EV++G S +++ +K L V Sbjct: 43 EVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEV-------------- 88 Query: 89 LSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTP 148 ++D L F+ + N H NI+ + S Sbjct: 89 --------------------CSEQDELDFLMEALIISKFN-HQNIVRCIGV--SLQSLPR 125 Query: 149 ALVFEYVDNVDFRILYPK----------LTDLEIRFYMFELLKALDYCHSMGIMHRDVKP 198 ++ E + D + + L L++ ++ Y +HRD+ Sbjct: 126 FILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAA 185 Query: 199 HNVMID--HKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLD 253 N ++ + ++ D+G+A + Y + + PE ++ ++ D Sbjct: 186 RNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFME-GIFTSKTD 244 Query: 254 LWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQ 313 WSFG +L + + SN + L + + P Y + Sbjct: 245 TWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTS--------GGRMDPPKNCPGPVY---R 293 Query: 314 YIRKPWHRFINDGNKHLSGNDEI 336 + + W D + I Sbjct: 294 IMTQCWQHQPEDRPNFAIILERI 316 >3ZZW-A nrPDB Length = 289 Score = 135 bits (340), Expect = 2e-32, Method: Composition-based stats. Identities = 47/324 (14%), Positives = 107/324 (33%), Gaps = 77/324 (23%) Query: 41 EIENKVGRGKYSEVFQGVKL-----DSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVP 95 ++G ++ +V++G + + IK LK + ++ E Sbjct: 12 RFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREE------------- 58 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 R + H N++ L ++ + +++F Y Sbjct: 59 ----------------------FRHEAMLRARLQHPNVVCLLGVVTK--DQPLSMIFSYC 94 Query: 156 DNVDF-------------------RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDV 196 + D R + L + + ++ ++Y S ++H+D+ Sbjct: 95 SHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDL 154 Query: 197 KPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLD 253 NV++ K +++ D GL + Y + S + PE ++ Y + D Sbjct: 155 ATRNVLVYDK-LNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIM-YGKFSIDSD 212 Query: 254 LWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQ 313 +WS+G +L + + G SN D + I + +L P Y + Sbjct: 213 IWSYGVVLWEVFSYGLQPYCGYSNQDVVEMI--------RNRQVLPCPDDCPAWVYAL-- 262 Query: 314 YIRKPWHRFINDGNKHLSGNDEII 337 + + W+ F + + + + Sbjct: 263 -MIECWNEFPSRRPRFKDIHSRLR 285 >4TPT-A nrPDB Length = 303 Score = 135 bits (339), Expect = 4e-32, Method: Composition-based stats. Identities = 42/254 (16%), Positives = 90/254 (35%), Gaps = 70/254 (27%) Query: 39 DYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK---IKREIKILTDLSNEKVP 95 D +G+G + + + + +V+K L ++ E+K++ L Sbjct: 1 DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLD----- 55 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 H N++ ++ K L+ EY+ Sbjct: 56 ----------------------------------HPNVLKFIGVLYK--DKKLNLLTEYI 79 Query: 156 DNVDFRILYPKLTD---LEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRL 212 + + + + + + + Y HSM I+HRD+ HN +I +K + + Sbjct: 80 EGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLI-KLDKTVVV 138 Query: 213 IDWGLAEFY---------------------HVNMEYNVRVASRFFKGPELLVDYRMYDYS 251 D+GL+ + + V + ++ PE+L + + YD + Sbjct: 139 ADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEML-NGKSYDET 197 Query: 252 LDLWSFGTMLASMI 265 +D++SFG +L +I Sbjct: 198 VDIFSFGIVLCEII 211 >5VD3-A nrPDB Length = 311 Score = 134 bits (337), Expect = 6e-32, Method: Composition-based stats. Identities = 55/350 (15%), Positives = 107/350 (30%), Gaps = 94/350 (26%) Query: 16 NKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVK 75 + R E ++ + ++ +++G G Y EVF+ + +K Sbjct: 47 DPSRPESFFQ------------QSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVK------ 88 Query: 76 KKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIH 135 + +D + + + H + Sbjct: 89 ---------------------------RSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVR 121 Query: 136 LFDIIKDPISKTPALVFEYVDNVDFRILYP----KLTDLEIRFYMFELLKALDYCHSMGI 191 L ++ L E + L + ++ Y+ + L AL + HS G+ Sbjct: 122 LEQAWEE--GGILYLQTELC-GPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGL 178 Query: 192 MHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYS 251 +H DVKP N+ + + + +L D+GL V+ + PELL Y + Sbjct: 179 VHLDVKPANIFLGPRG-RCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGS--YGTA 235 Query: 252 LDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDM 311 D++S G + + E G E + + LP EF Sbjct: 236 ADVFSLGLTILEVACNMELPHGG-------------------EGWQQLRQGYLPPEFT-- 274 Query: 312 DQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHP 361 + E+ ++ +L D + R TA+ + P Sbjct: 275 ------------------AGLSSELRSVLVMMLEPDPKLRATAEALLALP 306 >5IKW-A nrPDB Length = 310 Score = 133 bits (334), Expect = 1e-31, Method: Composition-based stats. Identities = 49/263 (18%), Positives = 91/263 (34%), Gaps = 64/263 (24%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML---KPVKKKKIKREIKILTDL 89 ++ +E + G +S VF V+ ++ +K + KREI I+ +L Sbjct: 9 FAVGRHQVTLEESLAEGGFSTVFL-VRTHGGIRCALKRMYVNNMPDLNVCKREITIMKEL 67 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 S GH NI+ D + IS Sbjct: 68 S--------------------------------------GHKNIVGYLDCAVNSISDNVW 89 Query: 150 LV---FEYVDNVDF-----RILYPKLTDLEIRFYMFELLKALDYCHSMG--IMHRDVKPH 199 V EY + L T+ E+ + +A+ H I+HRD+K Sbjct: 90 EVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVE 149 Query: 200 NVMIDHKNKKLRLIDWGLAEFYHVNMEYNV---------RVASRFFKGPELLV--DYRMY 248 N++++ + L D+G A +N + + + + ++ PE++ + Sbjct: 150 NILLNDGGNYV-LCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPI 208 Query: 249 DYSLDLWSFGTMLASMIFKREPF 271 D+W+ G +L + F PF Sbjct: 209 TTKADIWALGCLLYKLCFFTLPF 231 >3Q4U-A nrPDB Length = 301 Score = 131 bits (329), Expect = 5e-31, Method: Composition-based stats. Identities = 51/320 (15%), Positives = 108/320 (33%), Gaps = 71/320 (22%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 +D + VG+G+Y EV++G + +K+ +K RE Sbjct: 8 RDITLLECVGKGRYGEVWRGSWQ--GENVAVKIFSSRDEKSWFRE--------------- 50 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLF--DIIKDPISKTPALVFEYV 155 +++ H NI+ D+ S L+ Y Sbjct: 51 ----------------------TELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYH 88 Query: 156 DNVDFRILYPKLTDLEIR--FYMFELLKALDYCH--------SMGIMHRDVKPHNVMIDH 205 + T + + + L + H I HRD+K N+++ Sbjct: 89 EMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILV-K 147 Query: 206 KNKKLRLIDWGLAEFYHVNME-----YNVRVASRFFKGPELLVDYRMYD-----YSLDLW 255 KN + + D GLA + + N RV ++ + PE+L + D +D+W Sbjct: 148 KNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIW 207 Query: 256 SFGTMLAS---------MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPR 306 +FG +L ++ +P F+ D + ++ + D ++ + Sbjct: 208 AFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDP 267 Query: 307 EFYDMDQYIRKPWHRFINDG 326 + + +++ W++ + Sbjct: 268 TLTSLAKLMKECWYQNPSAR 287 >4FL3-A nrPDB Length = 635 Score = 131 bits (329), Expect = 6e-31, Method: Composition-based stats. Identities = 49/334 (14%), Positives = 112/334 (33%), Gaps = 80/334 (23%) Query: 11 VYTNINKQRTEE-YWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVK--LDSKVKIV 67 + + + R +E Y D + ++ + ++G G + V +G + Sbjct: 351 PFADPEEIRPKEVYLDRKLLTLE----------DKELGSGNFGTVKKGYYQMKKVVKTVA 400 Query: 68 IKMLK-----PVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYI 122 +K+LK P K ++ E ++ L N Sbjct: 401 VKILKNEANDPALKDELLAEANVMQQLDN------------------------------- 429 Query: 123 FDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK---LTDLEIRFYMFEL 179 I+ + I + +++ LV E + + + D I + ++ Sbjct: 430 --------PYIVRMIGICE---AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQV 478 Query: 180 LKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME-YNVRVASRF--- 235 + Y +HRD+ NV++ ++ ++ D+GL++ + Y + ++ Sbjct: 479 SMGMKYLEESNFVHRDLAARNVLLVTQHYA-KISDFGLSKALRADENYYKAQTHGKWPVK 537 Query: 236 FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEK 295 + PE + +Y + D+WSFG ++ + + G ++ + K Sbjct: 538 WYAPECI-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK--------G 588 Query: 296 YLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 + PRE YD+ W + + Sbjct: 589 ERMGCPAGCPREMYDLMNL---CWTYDVENRPGF 619 >5TE0-A nrPDB Length = 347 Score = 130 bits (327), Expect = 8e-31, Method: Composition-based stats. Identities = 55/350 (15%), Positives = 112/350 (32%), Gaps = 106/350 (30%) Query: 33 WSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML---KPVKKKKIKREIKILTDL 89 + + ++ + G ++ VF V+ + +K +K + + KREI+I+ DL Sbjct: 14 FGIGRQQVTVDEVLAEGGFAIVFL-VRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDL 72 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISK--- 146 S GH NI+ D + +S Sbjct: 73 S--------------------------------------GHKNIVGYIDSSINNVSSGDV 94 Query: 147 -TPALVFEYVDNVDFRILYPK-----LTDLEIRFYMFELLKALDYCHSMG--IMHRDVKP 198 ++ ++ L + T+ E+ + +A+ H I+HRD+K Sbjct: 95 WEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKV 154 Query: 199 HNVMIDHKNKKLRLIDWGLA--EFYHVNMEYNVRV-------ASRFFKGPEL--LVDYRM 247 N+++ H L D+G A +F + E V + ++ PE+ L ++ Sbjct: 155 ENILL-HDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKI 213 Query: 248 YDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPRE 307 D+W+ G +L + + PF + + + T+P Sbjct: 214 ITTKADIWALGCLLYKLCYFTLPF-------------------GESQVAICDGNFTIPDN 254 Query: 308 FYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEA 357 + ++ LI +L D +R + Sbjct: 255 ----------------------SRYSQDMHCLIRYMLEPDPDKRPDIYQV 282 >5WNO-A nrPDB Length = 330 Score = 130 bits (327), Expect = 8e-31, Method: Composition-based stats. Identities = 40/311 (12%), Positives = 95/311 (30%), Gaps = 64/311 (20%) Query: 41 EIENKVGRGKYSEVFQGVK-----LDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVP 95 +++ K+G G + VF G+ + K+ + IK+ + + + Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQT----------------- 67 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 + + H N++ + +V Y Sbjct: 68 --------------------DEMLEEATNMFRLRHDNLLKIIGFCMHDDG--LKIVTIYR 105 Query: 156 DNVDFRILYPKLTD----LEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 + + + E Y +++ + Y ++HRD+ NV++ N + Sbjct: 106 PLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFN-HVE 164 Query: 212 LIDWGLAEFY-HVNMEYNVRVASRF--FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 268 + D+GL++ H ++ + E+ + Y ++ D+W+FG +I Sbjct: 165 ITDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHC-YTHASDVWAFGVTCWEIITFG 223 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNK 328 + + G S + + L P D+ Q + + W Sbjct: 224 QSPYQGMSTDS--------IHNFLKDGNRLSQP---PNCSQDLYQELLRCWMADPKSRPG 272 Query: 329 HLSGNDEIIDL 339 + + Sbjct: 273 FEILYERFKEF 283 >5TOS-A nrPDB Length = 395 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 54/347 (15%), Positives = 113/347 (32%), Gaps = 87/347 (25%) Query: 37 TKDYEIENKVGRGKYSEVFQG---------VKLDSKVKIVIKMLKPVK---KKKIKREIK 84 T+++ ++ +G G + VF+G K + + I +K L ++ EI Sbjct: 64 TRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLTEIN 123 Query: 85 ILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI 144 L LS H N++ L + Sbjct: 124 YLGQLS---------------------------------------HPNLVKLIGYCLEDE 144 Query: 145 SKTPALVFEYVDNVDFR-------ILYPKLTDLEIRFYMFELLKALDYCHS--MGIMHRD 195 + LV+E++ + L + K L + HS + +++RD Sbjct: 145 HR--LLVYEFMQKGSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRD 202 Query: 196 VKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVR---VASRFFKGPELLVDYRMYDYSL 252 +K N+++D + +L D+GLA + V + + + PE + + Sbjct: 203 IKASNILLDA-DYNAKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYM-SSGHLNARS 260 Query: 253 DLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMD 312 D++SFG +L ++ + H + + L K ++ L + Sbjct: 261 DVYSFGVLLLEILSGKRALDHNRPAKE------ENLVDWARPYLTSKRKVLLIVDNRLDT 314 Query: 313 QYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMG 359 QY+ + R + L ++ + R T + + Sbjct: 315 QYLPEEAVRMASVAV--------------QCLSFEPKSRPTMDQVVR 347 >5LPZ-A nrPDB Length = 332 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 41/244 (16%), Positives = 85/244 (34%), Gaps = 54/244 (22%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 + ++ +G G + +V++ + D + IK L V + + Sbjct: 19 FHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDRE------------------ 59 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVD 159 + H N++ L K + LV+E++ Sbjct: 60 ------------------FMAEMETIGKIKHRNLVPLLGYCK--VGDERLLVYEFMKYGS 99 Query: 160 FRILYP-------KLTDLEIRFYMFELLKALDYCHSM---GIMHRDVKPHNVMIDHKNKK 209 + KL R + L + H I+HRD+K NV++D +N + Sbjct: 100 LEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLD-ENLE 158 Query: 210 LRLIDWGLAEFY---HVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 R+ D+G+A ++ + + + PE +R D++S+G +L ++ Sbjct: 159 ARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFR-CSTKGDVYSYGVVLLELLT 217 Query: 267 KREP 270 + P Sbjct: 218 GKRP 221 >5LPV-A nrPDB Length = 296 Score = 129 bits (323), Expect = 2e-30, Method: Composition-based stats. Identities = 41/244 (16%), Positives = 85/244 (34%), Gaps = 54/244 (22%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 + ++ +G G + +V++ + D + IK L V + + Sbjct: 19 FHNDSLIGSGGFGDVYKAILKD-GSAVAIKKLIHVSGQGDRE------------------ 59 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVD 159 + H N++ L K + LV+E++ Sbjct: 60 ------------------FMAEMETIGKIKHRNLVPLLGYCK--VGDERLLVYEFMKYGS 99 Query: 160 FRILYP-------KLTDLEIRFYMFELLKALDYCHSM---GIMHRDVKPHNVMIDHKNKK 209 + KL R + L + H I+HRD+K NV++D +N + Sbjct: 100 LEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLD-ENLE 158 Query: 210 LRLIDWGLAEFY---HVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 R+ D+G+A ++ + + + PE +R D++S+G +L ++ Sbjct: 159 ARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFR-CSTKGDVYSYGVVLLELLT 217 Query: 267 KREP 270 + P Sbjct: 218 GKRP 221 >4M66-A nrPDB Length = 325 Score = 128 bits (322), Expect = 4e-30, Method: Composition-based stats. Identities = 55/328 (16%), Positives = 113/328 (34%), Gaps = 69/328 (21%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKV 94 + ++ + VG+G + VF+ + +K++ KKI E+K + +L NE Sbjct: 17 VSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNS---KKISWEVKAMVNLRNE-- 71 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTP---ALV 151 N++ L + +D ALV Sbjct: 72 -------------------------------------NVLLLLGVTEDLQWDFVSGQALV 94 Query: 152 FEYVDNVDFRILYPKLTDLE---IRFYMFELLKALDYCHSMG--IMHRDVKPHNVMIDHK 206 +++N L + + E++ + Y HS+ ++HRD+KP N+++D + Sbjct: 95 TRFMENGSLAGLLQPEAPRPWPLLCRLLQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPE 154 Query: 207 NKKLRLIDWGLAEF-------YHVNMEYNVRVASRFFKGPELLVDYR-MYDYSLDLWSFG 258 +L D+GL+ F + + PELL + D++SFG Sbjct: 155 -LHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPELLFKVNLKASKASDVYSFG 213 Query: 259 TMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPRE--FYDMDQYIR 316 ++ +++ RE D+ I + + L + P + + + Sbjct: 214 ILVWAVLAGRE-----AELVDKTSLIRETVCDRQSRPPLTELPPGSPETPGLEKLKELMI 268 Query: 317 KPWHRFINDGNKHLSGND---EIIDLID 341 W + E+ +L+ Sbjct: 269 HCWGSQSENRPSFQDCEPKTNEVYNLVK 296 >5C26-A nrPDB Length = 299 Score = 128 bits (321), Expect = 4e-30, Method: Composition-based stats. Identities = 50/334 (14%), Positives = 112/334 (33%), Gaps = 80/334 (23%) Query: 11 VYTNINKQRTEE-YWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVK--LDSKVKIV 67 Y + + R +E Y D + ++ + ++G G + V +G + Sbjct: 9 PYADPEEIRPKEVYLDRKLLTLE----------DKELGSGNFGTVKKGYYQMKKVVKTVA 58 Query: 68 IKMLK-----PVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYI 122 +K+LK P K ++ E ++ L N Sbjct: 59 VKILKNEANDPALKDELLAEANVMQQLDN------------------------------- 87 Query: 123 FDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK---LTDLEIRFYMFEL 179 I+ + I + +++ LV E + + + D I + ++ Sbjct: 88 --------PYIVRMIGICE---AESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQV 136 Query: 180 LKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME-YNVRVASRF--- 235 + Y +HRD+ NV++ ++ ++ D+GL++ + Y + ++ Sbjct: 137 SMGMKYLEESNFVHRDLAARNVLLVTQHYA-KISDFGLSKALRADENYYKAQTHGKWPVK 195 Query: 236 FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEK 295 + PE + +Y + D+WSFG ++ + + G ++ + K Sbjct: 196 WYAPECI-NYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK--------G 246 Query: 296 YLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 329 + PRE YD+ W + + Sbjct: 247 ERMGCPAGCPREMYDLMNL---CWTYDVENRPGF 277 >2QKW-B nrPDB Length = 321 Score = 127 bits (320), Expect = 6e-30, Method: Composition-based stats. Identities = 41/254 (16%), Positives = 94/254 (37%), Gaps = 51/254 (20%) Query: 23 YWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKRE 82 + Y ++D T +++ + +G G + +V++GV D K+ +K P + Sbjct: 24 FESYRVPLVDLEEATNNFDHKFLIGHGVFGKVYKGVLRD-GAKVALKRRTPESSQG---- 78 Query: 83 IKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD 142 ++ I H +++ L + Sbjct: 79 --------------------------------IEEFETEIETLSFCRHPHLVSLIGFCDE 106 Query: 143 PISKTPALVFEYVDNVDFRILY-------PKLTDLEIRFYMFELLKALDYCHSMGIMHRD 195 L+++Y++N + + ++ + + L Y H+ I+HRD Sbjct: 107 --RNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAIIHRD 164 Query: 196 VKPHNVMIDHKNKKLRLIDWGLAE---FYHVNMEYNVRVASRFFKGPELLVDYRMYDYSL 252 VK N+++D +N ++ D+G+++ V + + PE + R+ Sbjct: 165 VKSINILLD-ENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRL-TEKS 222 Query: 253 DLWSFGTMLASMIF 266 D++SFG +L ++ Sbjct: 223 DVYSFGVVLFEVLC 236 >2Y4I-B nrPDB Length = 319 Score = 127 bits (319), Expect = 7e-30, Method: Composition-based stats. Identities = 55/348 (15%), Positives = 114/348 (32%), Gaps = 82/348 (23%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSN 91 +W + EI +G+G++ +V+ G ++ I+++ Sbjct: 27 EWDIPFEQLEIGELIGKGRFGQVYHGRW---HGEVAIRLID------------------- 64 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 ED LK + + H N++ P A++ Sbjct: 65 ---------------IERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPH--LAII 107 Query: 152 FEYVDNVDF----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN 207 R L + R E++K + Y H+ GI+H+D+K NV D N Sbjct: 108 TSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYD--N 165 Query: 208 KKLRLIDWGL---AEFYHVNMEYNVRVASRFF---KGPELLVDYR--------MYDYSLD 253 K+ + D+GL + + + PE++ + D Sbjct: 166 GKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSD 225 Query: 254 LWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQ 313 +++ GT+ + + PF T I+ +GT +K ++ ++ Sbjct: 226 VFALGTIWYELHAREWPF-----KTQPAEAIIWQMGTG------MKPNLSQIGMGKEISD 274 Query: 314 YIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHP 361 + W + ++D+++ L + + RL+ HP Sbjct: 275 ILLFCWAFEQEERPTFTK----LMDMLEKLPKRN--RRLS------HP 310 >3MY0-A nrPDB Length = 305 Score = 127 bits (318), Expect = 9e-30, Method: Composition-based stats. Identities = 54/316 (17%), Positives = 103/316 (32%), Gaps = 71/316 (22%) Query: 42 IENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPF 101 + VG+G+Y EV++G+ + +K+ ++ RE +I Sbjct: 12 LVECVGKGRYGEVWRGLWH--GESVAVKIFSSRDEQSWFRETEI---------------- 53 Query: 102 QKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLF--DIIKDPISKTPALVFEYVDNVD 159 ++ H NI+ D+ S L+ Y ++ Sbjct: 54 ---------------------YNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGS 92 Query: 160 FRILYPK--LTDLEIRFYMFELLKALDYCH--------SMGIMHRDVKPHNVMIDHKNKK 209 + L L + H I HRD K NV++ N + Sbjct: 93 LYDFLQRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLV-KSNLQ 151 Query: 210 LRLIDWGLAEFYHVNMEY-----NVRVASRFFKGPELLVDYRMYD-----YSLDLWSFGT 259 + D GLA + +Y N RV ++ + PE+L + D D+W+FG Sbjct: 152 CCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGL 211 Query: 260 MLASMIFK---------REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYD 310 +L + + P F+ D + +K + D + + + Sbjct: 212 VLWEIARRTIVNGIVEDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSG 271 Query: 311 MDQYIRKPWHRFINDG 326 + Q +R+ W+ + Sbjct: 272 LAQMMRECWYPNPSAR 287 >2BUJ-A nrPDB Length = 317 Score = 127 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 53/357 (14%), Positives = 117/357 (32%), Gaps = 105/357 (29%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKML---KPVKKKKIKREIKILTDLSN 91 + K Y K+G G +S V L +K + + +++ +RE + Sbjct: 26 IDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADM------ 79 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII--KDPISKTPA 149 H NI+ L + Sbjct: 80 ---------------------------------HRLFNHPNILRLVAYCLRERGAKHEAW 106 Query: 150 LVFEYVDNVDF-------RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM 202 L+ + + LT+ +I + + + + L+ H+ G HRD+KP N++ Sbjct: 107 LLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNIL 166 Query: 203 IDHKNKKLRLIDWGL----------AEFYHVNMEYNVRVASRFFKGPEL--LVDYRMYDY 250 + + + + L+D G + ++ + + ++ PEL + + + D Sbjct: 167 LGDEGQPV-LMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDE 225 Query: 251 SLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYD 310 D+WS G +L +M+F P+ V D ++ ++++P+ Sbjct: 226 RTDVWSLGCVLYAMMFGEGPY-------------DMVFQKGDSVALAVQNQLSIPQ---- 268 Query: 311 MDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQER------LTAKEAMGHP 361 + + L+++++ D +R L+ EA+ P Sbjct: 269 ------------------SPRHSSALWQLLNSMMTVDPHQRPHIPLLLSQLEALQPP 307 >3LMG-A nrPDB Length = 344 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 42/265 (15%), Positives = 88/265 (33%), Gaps = 47/265 (17%) Query: 15 INKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPV 74 I E N V+ + +G G + V +GV + I I Sbjct: 11 IEPLDPSE---KANKVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKI------ 61 Query: 75 KKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANII 134 P + + ++ HA+I+ Sbjct: 62 -------------------------PVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIV 96 Query: 135 HLFDIIKDPISKTPALVFEYVDNVDF----RILYPKLTDLEIRFYMFELLKALDYCHSMG 190 L + + LV +Y+ R L + + ++ K + Y G Sbjct: 97 RLLGLC---PGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHG 153 Query: 191 IMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME---YNVRVASRFFKGPELLVDYRM 247 ++HR++ NV++ + ++++ D+G+A+ + + Y+ + E + + Sbjct: 154 MVHRNLAARNVLLKSPS-QVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESI-HFGK 211 Query: 248 YDYSLDLWSFGTMLAS-MIFKREPF 271 Y + D+WS+G + M F EP+ Sbjct: 212 YTHQSDVWSYGVTVWELMTFGAEPY 236 >3UIM-A nrPDB Length = 326 Score = 126 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 42/255 (16%), Positives = 88/255 (34%), Gaps = 52/255 (20%) Query: 29 TVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTD 88 ++ + + ++ +N +GRG + +V++G D + +K LK Sbjct: 21 SLRELQVASDNFSNKNILGRGGFGKVYKGRLAD-GTLVAVKRLK---------------- 63 Query: 89 LSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTP 148 + + + + H N++ L P + Sbjct: 64 -------------------EERTQGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERL- 103 Query: 149 ALVFEYVDNVDFRILYPKLTDLE-------IRFYMFELLKALDYCHSM---GIMHRDVKP 198 LV+ Y+ N + + + + + L Y H I+HRDVK Sbjct: 104 -LVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKIIHRDVKA 162 Query: 199 HNVMIDHKNKKLRLIDWGLAEFYHVNMEY--NVRVASRFFKGPELLVDYRMYDYSLDLWS 256 N+++D + + + + D+GLA+ + + PE L + D++ Sbjct: 163 ANILLDEEFEAV-VGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKS-SEKTDVFG 220 Query: 257 FGTMLASMIFKREPF 271 +G ML +I + F Sbjct: 221 YGVMLLELITGQRAF 235 >6J5U-C nrPDB Length = 426 Score = 125 bits (314), Expect = 3e-29, Method: Composition-based stats. Identities = 48/255 (18%), Positives = 93/255 (36%), Gaps = 65/255 (25%) Query: 37 TKDYEIENKVGRGKYSEVFQG---------VKLDSKVKIVIKMLKPVK---KKKIKREIK 84 TK++ +N +G G + VF+G + S + + +K LKP K+ E+ Sbjct: 83 TKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKEWLTEVN 142 Query: 85 ILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI 144 L LS H N++ L + Sbjct: 143 YLGQLS---------------------------------------HPNLVLLVGYCAEGE 163 Query: 145 SKTPALVFEYVDNVDFRILYPKLTDLEIRFYMF-----ELLKALDYCHSMG--IMHRDVK 197 ++ LV+E++ + + + + K L + H +++RD K Sbjct: 164 NR--LLVYEFMPKGSLENHLFRRGAQPLTWAIRMKVAVGAAKGLTFLHEAKSQVIYRDFK 221 Query: 198 PHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVR---VASRFFKGPELLVDYRMYDYSLDL 254 N+++D + +L D+GLA+ +V + + + PE + R+ D+ Sbjct: 222 AANILLDA-DFNAKLSDFGLAKAGPTGDNTHVSTKVIGTHGYAAPEYVATGRL-TAKSDV 279 Query: 255 WSFGTMLASMIFKRE 269 +SFG +L +I R Sbjct: 280 YSFGVVLLELISGRR 294 >3G2F-A nrPDB Length = 336 Score = 124 bits (311), Expect = 6e-29, Method: Composition-based stats. Identities = 56/359 (15%), Positives = 109/359 (30%), Gaps = 83/359 (23%) Query: 27 ENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKIL 86 E + S + + ++ +GRG+Y V++G + + +K+ ++ E I Sbjct: 2 EAAASEPSLDLDNLKLLELIGRGRYGAVYKG--SLDERPVAVKVFSFANRQNFINEKNI- 58 Query: 87 TDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLF---DIIKDP 143 + P H NI + + Sbjct: 59 ------------------------------------YRVPLMEHDNIARFIVGDERVTAD 82 Query: 144 ISKTPALVFEYVDNVDFRILYPKLTDLEIRF--YMFELLKALDYCHSM---------GIM 192 LV EY N T + + + L Y H+ I Sbjct: 83 GRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAIS 142 Query: 193 HRDVKPHNVMIDHKNKKLRLIDWGLA------EFYHVNMEYNVR---VASRFFKGPELLV 243 HRD+ NV++ + + + D+GL+ E N V + + PE+L Sbjct: 143 HRDLNSRNVLVKNDGTCV-ISDFGLSMRLTGNRLVRPGEEDNAAISEVGTIRYMAPEVLE 201 Query: 244 D------YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTD-QLVKIVKVLGTSDFEKY 296 +D+++ G + + + F G S + Q+ +V FE Sbjct: 202 GAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDM 261 Query: 297 LLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAK 355 + K +F ++ + + I++ D + RLTA+ Sbjct: 262 QVLVS-------------REKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQ 307 >3MDY-A nrPDB Length = 337 Score = 124 bits (310), Expect = 9e-29, Method: Composition-based stats. Identities = 60/343 (17%), Positives = 113/343 (32%), Gaps = 86/343 (25%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 K ++ ++G+G+Y EV+ G K+ +K+ Sbjct: 37 KQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKV--------------------------- 67 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLF--DIIKDPISKTPALVFEYV 155 E+ F I+ H NI+ DI L+ +Y Sbjct: 68 ----------FFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYH 117 Query: 156 DNVDFRILYPK--LTDLEIRFYMFELLKALDYCHSM--------GIMHRDVKPHNVMIDH 205 +N L + + + L + H+ I HRD+K N+++ Sbjct: 118 ENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILV-K 176 Query: 206 KNKKLRLIDWGLAEFYHVNME-----YNVRVASRFFKGPELLVD------YRMYDYSLDL 254 KN + D GLA + + N RV ++ + PE+L + ++ Y D+ Sbjct: 177 KNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSY-IMADM 235 Query: 255 WSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPRE--FYDMD 312 +SFG +L + + + E+Y L Y +P + + DM Sbjct: 236 YSFGLILWEVA-------------------RRCVSGGIVEEYQLPYHDLVPSDPSYEDMR 276 Query: 313 QYI-RKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTA 354 + + K + ++ L+ ++ RLTA Sbjct: 277 EIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTA 319 >5XD6-A nrPDB Length = 305 Score = 121 bits (304), Expect = 4e-28, Method: Composition-based stats. Identities = 47/264 (17%), Positives = 90/264 (34%), Gaps = 64/264 (24%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK--KKIKREIKILTDLSNEKV 94 T +Y ++ +G G Y VF G+ L S IK L K+ ++ ++ +++ L E Sbjct: 21 TDNYGSKSLIGEGSYGRVFYGI-LKSGKAAAIKKLDSSKQPDQEFLAQVSMVSRLRQE-- 77 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEY 154 N++ L D + L +EY Sbjct: 78 -------------------------------------NVVALLGYCVDGPLR--VLAYEY 98 Query: 155 VDNVDFRILY------------PKLTDLEIRFYMFELLKALDYCHSM---GIMHRDVKPH 199 N + P L+ + + L+Y H ++HRD+K Sbjct: 99 APNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAARGLEYLHEKANPHVIHRDIKSS 158 Query: 200 NVMIDHKNKKLRLIDWGLAEFYHVNMEY---NVRVASRFFKGPELLVDYRMYDYSLDLWS 256 NV++ + ++ D+ L+ + + + PE + + D++S Sbjct: 159 NVLLFDDD-VAKIADFDLSNQAPDMAARLHSTRVLGTFGYHAPEYAMTGTL-STKSDVYS 216 Query: 257 FGTMLASMIFKREPFFHGTSNTDQ 280 FG +L ++ R+P H Q Sbjct: 217 FGVVLLELLTGRKPVDHTLPRGQQ 240 >2PZI-A nrPDB Length = 681 Score = 119 bits (297), Expect = 3e-27, Method: Composition-based stats. Identities = 66/265 (24%), Positives = 107/265 (40%), Gaps = 36/265 (13%) Query: 130 HANIIHLFDIIKDPISKT---PALVFEYVDNVDF-RILYPKLTDLEIRFYMFELLKALDY 185 H +I+ +F+ ++ +V EYV R KL E Y+ E+L AL Y Sbjct: 138 HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSY 197 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDY 245 HS+G+++ D+KP N+M+ + +L+LID G + + F+ PE++ Sbjct: 198 LHSIGLVYNDLKPENIMLTEE--QLKLIDLGAVSRINSFGYLY---GTPGFQAPEIVRTG 252 Query: 246 RMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLP 305 + D+++ G LA+ + P +G D L + VL T D LL+ I Sbjct: 253 P--TVATDIYTVGRTLAA-LTLDLPTRNGR-YVDGLPEDDPVLKTYDSYGRLLRRAIDPD 308 Query: 306 -------------------REFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRY 346 RE D + +P I ++ G D ++ D L Sbjct: 309 PRQRFTTAEEMSAQLTGVLREVVAQDTGVPRPGLSTIFSPSRSTFGVDLLVAHTDVYLDG 368 Query: 347 D-HQERLTAKE---AMGHPWFAPIR 367 H E+LTA E A+ P P Sbjct: 369 QVHAEKLTANEIVTALSVPLVDPTD 393 >4LQP-A nrPDB Length = 508 Score = 118 bits (296), Expect = 3e-27, Method: Composition-based stats. Identities = 41/196 (20%), Positives = 80/196 (40%), Gaps = 39/196 (19%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 +D+ +G+G + EV K D+ +K L +K E Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTL-------LKSE--------------- 139 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 K+D L ++ + ++ L+ +D ++ L+ E++ Sbjct: 140 -----------MYKKDQLAHVKAERDVLAGSDSPWVVSLYYSFQD--AQYLYLIMEFLPG 186 Query: 158 VDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLID 214 D + + T+ RFYM E + A++ H +G +HR +KP N++ID + ++L D Sbjct: 187 GDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKLGFIHRAIKPDNILIDIRG-HIKLSD 245 Query: 215 WGLAEFYHVNMEYNVR 230 +GL+ +H + N Sbjct: 246 FGLSTGFHKTHDSNYY 261 >5AR8-A nrPDB Length = 326 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 51/341 (14%), Positives = 120/341 (35%), Gaps = 82/341 (24%) Query: 43 ENKVGRGKYSEVFQGVKLDSKVKIVIKMLK------PVKKKKIKREIKILTDLSNEKVPP 96 + RG V D +V++ +K L ++K + RE +IL Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSY--- 93 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 I+ + I +P + +V EY+ Sbjct: 94 ------------------------------------ILPILGICNEP--EFLGIVTEYMP 115 Query: 157 NVDFRILYPKLTD-LEIRF-----YMFELLKALDYCHSMG--IMHRDVKPHNVMIDHKNK 208 N L + T+ ++ + + E+ ++Y H+M ++H D+K N+++D++ Sbjct: 116 NGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNE-F 174 Query: 209 KLRLIDWGLAEFYHVNMEYNVR------VASRFFKGPELLVDYRMY--DYSLDLWSFGTM 260 +++ D+GL+++ +++ + + + PE + D++S+ + Sbjct: 175 HVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVI 234 Query: 261 LASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWH 320 ++ +++PF T+ + + + E+ L +P M I W Sbjct: 235 TWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESL---PYDIPHRAR-MISLIESGWA 290 Query: 321 RFINDGNKHLSGNDEIIDLIDNLLRYDHQER----LTAKEA 357 + ++ + L+ + R +T EA Sbjct: 291 QNPDERPS----------FLKCLIELEPVLRTFEEITFLEA 321 >4Y12-A nrPDB Length = 375 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 50/191 (26%), Positives = 87/191 (45%), Gaps = 14/191 (7%) Query: 130 HANIIHLFDIIKDPISKT---PALVFEYVDNVDF-RILYPKLTDLEIRFYMFELLKALDY 185 H +I+ +F+ ++ +V EYV R KL E Y+ E+L AL Y Sbjct: 177 HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPVAEAIAYLLEILPALSY 236 Query: 186 CHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDY 245 HS+G+++ D+KP N+M+ + +L+LID G + + F+ PE++ Sbjct: 237 LHSIGLVYNDLKPENIMLTEE--QLKLIDLGAVSRINSFGYLY---GTPGFQAPEIVRTG 291 Query: 246 RMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL- 304 + D+++ G LA+ + P +G D L + VL T D LL+ I Sbjct: 292 P--TVATDIYTVGRTLAA-LTLDLPTRNGR-YVDGLPEDDPVLKTYDSYGRLLRRAIDPD 347 Query: 305 PREFYDMDQYI 315 PR+ + + + Sbjct: 348 PRQRFTTAEEM 358 >1PY5-A nrPDB Length = 326 Score = 115 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 45/311 (14%), Positives = 108/311 (34%), Gaps = 73/311 (23%) Query: 42 IENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPF 101 ++ +G+G++ EV++G ++ +K+ +++ RE +I Sbjct: 33 LQESIGKGRFGEVWRGKWR--GEEVAVKIFSSREERSWFREAEI---------------- 74 Query: 102 QKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLF--DIIKDPISKTPALVFEYVDNVD 159 + H NI+ D + LV +Y ++ Sbjct: 75 ---------------------YQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGS 113 Query: 160 FRILYPKL--TDLEIRFYMFELLKALDYCH--------SMGIMHRDVKPHNVMIDHKNKK 209 + T + L + H I HRD+K N+++ KN Sbjct: 114 LFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILV-KKNGT 172 Query: 210 LRLIDWGLAEFYH-----VNMEYNVRVASRFFKGPELL---VDYRMYD--YSLDLWSFGT 259 + D GLA + +++ N RV ++ + PE+L ++ + ++ D+++ G Sbjct: 173 CCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGL 232 Query: 260 MLASMIFK----------REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFY 309 + + + + P++ + + ++ KV+ + + Sbjct: 233 VFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSC-EALR 291 Query: 310 DMDQYIRKPWH 320 M + +R+ W+ Sbjct: 292 VMAKIMRECWY 302 >4M69-B nrPDB Length = 283 Score = 114 bits (286), Expect = 5e-26, Method: Composition-based stats. Identities = 45/230 (19%), Positives = 91/230 (39%), Gaps = 17/230 (7%) Query: 120 PYIFDQPHNGHANIIHLFDIIKDPISKTP--ALVFEYVDNVDFRILYPKLTDLEIRFYMF 177 I NI+ +F I D K P ++V EY + R L + DL + Sbjct: 57 DEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSL 116 Query: 178 ELLK---ALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHV-----NMEYNV 229 +L+ L H +HR++ + ++ +++L + L++ + Sbjct: 117 LVLRAARGLYRLHHSETLHRNISSSSFLV-AGGYQVKLAGFELSKTQNSISRTAKSTKAE 175 Query: 230 RVASRFFKGPELLVD-YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVL 288 R +S + PE L + + +YD +++SFG +L + + PF S KI +++ Sbjct: 176 RSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDS-----KKIRELV 230 Query: 289 GTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIID 338 ++ + + L RE + + ++ + LS +E D Sbjct: 231 AEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILERLSAVEESTD 280 >4BTF-A nrPDB Length = 469 Score = 114 bits (285), Expect = 6e-26, Method: Composition-based stats. Identities = 45/230 (19%), Positives = 91/230 (39%), Gaps = 17/230 (7%) Query: 120 PYIFDQPHNGHANIIHLFDIIKDPISKTP--ALVFEYVDNVDFRILYPKLTDLEIRFYMF 177 I NI+ +F I D K P ++V EY + R L + DL + Sbjct: 243 DEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSL 302 Query: 178 ELLK---ALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHV-----NMEYNV 229 +L+ L H +HR++ + ++ +++L + L++ + Sbjct: 303 LVLRAARGLYRLHHSETLHRNISSSSFLV-AGGYQVKLAGFELSKTQNSISRTAKSTKAE 361 Query: 230 RVASRFFKGPELLVD-YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVL 288 R +S + PE L + + +YD +++SFG +L + + PF S KI +++ Sbjct: 362 RSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDS-----KKIRELV 416 Query: 289 GTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIID 338 ++ + + L RE + + ++ + LS +E D Sbjct: 417 AEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILERLSAVEESTD 466 >2H34-A nrPDB Length = 309 Score = 114 bits (284), Expect = 8e-26, Method: Composition-based stats. Identities = 49/322 (15%), Positives = 108/322 (33%), Gaps = 67/322 (20%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK------PVKKKKIKREIKILTDLSNEK 93 Y + VGRG +V++ + + +K++ PV + +++RE + L Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQE-- 93 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 +++ + D I + Sbjct: 94 -------------------------------------PHVVPIHDF--GEIDGQLYVDMR 114 Query: 154 YVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKL 210 ++ VD + + L + ++ ALD H+ G HRDVKP N+++ + Sbjct: 115 LINGVDLAAMLRRQGPLAPPRAVAIVRQIGSALDAAHAAGATHRDVKPENILVSADDFAY 174 Query: 211 RLIDWGLAEFYHVN--MEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKR 268 L+D+G+A + V + ++ PE + Y D+++ +L + Sbjct: 175 -LVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESHA-TYRADIYALTCVLYECLTGS 232 Query: 269 EPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGN- 327 P+ DQL + + + ++ I + + + P R++ G+ Sbjct: 233 PPY-----QGDQLSVMGAHINQAIPRPSTVRPGIPVAFDAVIARGMAKNPEDRYVTCGDL 287 Query: 328 -------KHLSGNDEIIDLIDN 342 + D D++ Sbjct: 288 SAAAHAALATADQDRATDILRR 309 >4JRN-A nrPDB Length = 372 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 48/307 (15%), Positives = 104/307 (33%), Gaps = 35/307 (11%) Query: 46 VGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQ 105 +G G ++ V++ +++ ++ +K+ K+ + + DL E K Sbjct: 76 LGSGGFATVYEATDVETNEELAVKVFMSEKEPT----DETMLDLQRESSCYRNFSLAKTA 131 Query: 106 YYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN-------- 157 + + + + +I L L+ + Sbjct: 132 KDAQESCRFMVPSDVVMLEGQPASTEVVIGL----TTRWVPNYFLLMMRAEADMSKVISW 187 Query: 158 --VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDW 215 D + + + + + +K + + GI+H D+KP N ++ K+ +L L D+ Sbjct: 188 VFGDASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLL-LKDGRLFLGDF 246 Query: 216 GLAEFYHVNMEYNVRVASRFFKGPELLVDYRM--YDYSLDLWSFGTMLASMIFKREP--- 270 G Y +N + + ++ PE Y + D W G L + K P Sbjct: 247 G---TYRINNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTPA 303 Query: 271 --------FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 F S + + +++ L D +K +L + F +MD ++ F Sbjct: 304 DGIWDYLHFADCPSTPELVQDLIRSLLNRDPQKRMLPLQALETAAFKEMDSVVKGAAQNF 363 Query: 323 INDGNKH 329 + H Sbjct: 364 EQQEHLH 370 >5E8V-A nrPDB Length = 316 Score = 110 bits (274), Expect = 1e-24, Method: Composition-based stats. Identities = 52/343 (15%), Positives = 113/343 (32%), Gaps = 81/343 (23%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSK----VKIVIKMLKPVKKKKIKREIKILTDLSNEKVP 95 E++ VG+G+++EV++ + + +K+ + K E I +D++ Sbjct: 11 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDIN----- 65 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLF--DIIKDPISKTPALVFE 153 H NI+ + K + K L+ Sbjct: 66 --------------------------------LKHENILQFLTAEERKTELGKQYWLITA 93 Query: 154 YVDNVDFRILYPK--LTDLEIRFYMFELLKALDYCHS---------MGIMHRDVKPHNVM 202 + + + + ++ ++R L + + + HS M I+HRD+K N++ Sbjct: 94 FHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNIL 153 Query: 203 IDHKNKKLRLIDWGLAEFYH-----VNMEYNVRVASRFFKGPELLVDYRMYD-----YSL 252 + + + L D+GL+ ++ + +V + + PE+L + Sbjct: 154 VKN-DLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLASAMNLENVESFKQT 212 Query: 253 DLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMD 312 D++S +L M + V D+E P D Sbjct: 213 DVYSMALVLWEMTSRCN----------------AVGEVKDYEPPFGSKVREHPCVASMAD 256 Query: 313 QYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAK 355 + I + G + + + +D + RLTA+ Sbjct: 257 NVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQ 299 >5OAT-A nrPDB Length = 411 Score = 108 bits (270), Expect = 4e-24, Method: Composition-based stats. Identities = 55/359 (15%), Positives = 107/359 (29%), Gaps = 85/359 (23%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLD-----SKVKIVIKMLKPVKKKKIKREIKILTDL 89 D + + +G V+ D +K +KM+ ++ EI Sbjct: 8 ITLNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEI------ 61 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI----- 144 + + Y + + I + H NI+ +F + D Sbjct: 62 ----LKAMYRETVPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALP 117 Query: 145 ----------SKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHR 194 + + L+ + D L + + +LL+ + + + GI HR Sbjct: 118 PRLHPEGEGRNMSLFLLMKRYDCNLQSFLSTAPSTRTSLLLLAQLLEGVAHMTAHGIAHR 177 Query: 195 DVKPHNVMID---HKNKKLRLIDWGLAEFYHVNM---EYNVR----VASRFFKGPELLVD 244 D+K N+++D ++ L + D+G N Y + PE++ Sbjct: 178 DLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQ 237 Query: 245 YRM------YDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLL 298 Y DLW+ G + + PF+ K Sbjct: 238 KPGTFSVLNYS-KADLWAVGAIAYEIFNCHNPFYG-----------------PSRLKNFN 279 Query: 299 KYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEA 357 E LP+ ++ I+ L+ NLL+ + +RL + A Sbjct: 280 YKEGDLPKLPDEVPTVIQA---------------------LVANLLKRNPNKRLDPEVA 317 >5X1R-A nrPDB Length = 302 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 40/258 (15%), Positives = 87/258 (33%), Gaps = 35/258 (13%) Query: 26 YENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKI 85 + + ++EI+ +G G + V++ + I IK P K ++ I Sbjct: 9 PNSNSLPSGYRFNEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSI 68 Query: 86 LTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPIS 145 + + + + L H ++H+ ++ + Sbjct: 69 ---------------GLRGERFGKTFQAGLNSFIQEARLLARFSHPGLLHVLRFWEE--N 111 Query: 146 KTPALVFEYVDNVDFRILY----PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNV 201 T + ++ + L K+ + IR + L A++ H G +HRD+ N+ Sbjct: 112 GTAYMGTQFYSGTTLKNLQAQQPEKIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNI 171 Query: 202 MIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSL--------D 253 I + L+D+G A N+ + + P Y + D Sbjct: 172 QIQESQLPV-LLDFGSARKEIGNLSDETEIVLKPGFAP-----IEQYTENSDGEQGPWTD 225 Query: 254 LWSFGTMLASMIFKREPF 271 +++ G +L ++I P Sbjct: 226 IYALGAVLHTLIVGSPPP 243 >5J0A-A nrPDB Length = 300 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 42/241 (17%), Positives = 82/241 (34%), Gaps = 15/241 (6%) Query: 116 KFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK--------L 167 K + H NI+ + + + L EY L + Sbjct: 59 KRLMDEAKILKSLHHPNIVG-YRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPF 117 Query: 168 TDLEIRFYMFELLKALDYCHS-MGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME 226 I + + L Y H ++H D+K NV+I + +++ D G++ NME Sbjct: 118 PAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENME 177 Query: 227 YNV----RVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLV 282 + + +K E + + + D+++FG L M+ P + +++ D Sbjct: 178 VTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDED 237 Query: 283 KIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDN 342 K D E Y P ++D+ +K F N+ +++ Sbjct: 238 KTFD-ESDFDDEAYYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEA 296 Query: 343 L 343 L Sbjct: 297 L 297 >3SOC-A nrPDB Length = 322 Score = 105 bits (261), Expect = 4e-23, Method: Composition-based stats. Identities = 52/337 (15%), Positives = 108/337 (32%), Gaps = 78/337 (23%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 ++ RG++ V++ L + +K+ K+ + E ++ Sbjct: 26 LQLLEVKARGRFGCVWKAQLL--NEYVAVKIFPIQDKQSWQNEYEV-------------- 69 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKT--PALVFEYVDN 157 + P H NI+ K S L+ + + Sbjct: 70 -----------------------YSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEK 106 Query: 158 VDFRILYPK--LTDLEIRFYMFELLKALDYCHSM----------GIMHRDVKPHNVMIDH 205 ++ E+ + + L Y H I HRD+K NV++ + Sbjct: 107 GSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKN 166 Query: 206 KNKKLRLIDWGLAEFYHVN---MEYNVRVASRFFKGPELLVDYRMYDY----SLDLWSFG 258 N + D+GLA + + + +V +R + PE+L + +D+++ G Sbjct: 167 -NLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMG 225 Query: 259 TMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKP 318 +L + + G D + EI DM + + Sbjct: 226 LVLWELAS----------------RCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHK 269 Query: 319 WHR-FINDGNKHLSGNDEIIDLIDNLLRYDHQERLTA 354 R + D + +G + + I+ +D + RL+A Sbjct: 270 KKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSA 306 >4MWI-A nrPDB Length = 294 Score = 103 bits (256), Expect = 1e-22, Method: Composition-based stats. Identities = 55/309 (17%), Positives = 102/309 (33%), Gaps = 54/309 (17%) Query: 68 IKMLKPVKKKK----IKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIF 123 IK +K + + RE ++ T E + V + I Sbjct: 16 IKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIK 75 Query: 124 DQPHNGHANIIHLFDIIKDPISKTP--ALVFEYVDNVDFRILYPKLTDLEIRFYMFELL- 180 NI+ +F I D P ++V EY + R L + DL + M +L Sbjct: 76 TMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTLRELLDREKDLTLGKRMVLVLG 135 Query: 181 --KALDYCHSMGI--MHRDVKPHNVMIDHKNKKLRLIDWGLAEF-----YHVNMEYNVRV 231 + L H +H ++ N ++ + +++L + L + E RV Sbjct: 136 AARGLYRLHHSEAPELHGKIRSSNFLVT-QGYQVKLAGFELRKTQTSMSLGTTREKTDRV 194 Query: 232 ASRFFKGPELLVD-YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGT 290 S + P+ L D + YD +++SFG +L + PF N++++ K+V V Sbjct: 195 KSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDIPFQGC--NSEKIRKLVAVKRQ 252 Query: 291 SDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQE 350 + E+ ++ID +D Sbjct: 253 QEPLGEDCP----------------------------------SELREIIDECRAHDPSV 278 Query: 351 RLTAKEAMG 359 R + E + Sbjct: 279 RPSVDEILK 287 >2QLU-A nrPDB Length = 314 Score = 101 bits (251), Expect = 5e-22, Method: Composition-based stats. Identities = 49/341 (14%), Positives = 103/341 (30%), Gaps = 75/341 (21%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKV 94 ++ RG++ V++ + + +K+ K+ + E Sbjct: 12 VPRGSLQLLEIKARGRFGCVWKAQLM--NDFVAVKIFPLQDKQSWQSE------------ 57 Query: 95 PPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIK--DPISKTPALVF 152 IF P H N++ K + L+ Sbjct: 58 -------------------------REIFSTPGMKHENLLQFIAAEKRGSNLEVELWLIT 92 Query: 153 EYVDNVDFRILYPK--LTDLEIRFYMFELLKALDYCHSM-----------GIMHRDVKPH 199 + D +T E+ + + L Y H I HRD K Sbjct: 93 AFHDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSK 152 Query: 200 NVMIDHKNKKLRLIDWGLAEFYHVN---MEYNVRVASRFFKGPELLVDYRMYDY----SL 252 NV++ + L D+GLA + + + +V +R + PE+L + + Sbjct: 153 NVLLKSDLTAV-LADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRI 211 Query: 253 DLWSFGTMLASMIFKRE-----------PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYE 301 D+++ G +L ++ + + PF L ++ +V+ + + Sbjct: 212 DMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHW 271 Query: 302 ITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDN 342 + P + I + W + +E + LI Sbjct: 272 LKHP-GLAQLCVTIEECWDHD-AEARLSAGCVEERVSLIRR 310 >3SV0-A nrPDB Length = 483 Score = 100 bits (250), Expect = 7e-22, Method: Composition-based stats. Identities = 45/287 (15%), Positives = 92/287 (32%), Gaps = 55/287 (19%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 + + K+G G + E++ G + + ++ IK+ K Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTK--------------------- 45 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD- 156 +L + Y Q G N + F + D LV + + Sbjct: 46 -------------HPQLLYESKIYRILQGGTGIPN-VRWFGVEGD----YNVLVMDLLGP 87 Query: 157 --NVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM--IDHKNKKLRL 212 F KL+ + +++ +++ HS +HRD+KP N + + + ++ + Sbjct: 88 SLEDLFNFCSRKLSLKTVLMLADQMINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYI 147 Query: 213 IDWGLAEFYHVNMEY--------NVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASM 264 ID+GLA+ Y + + + + DL S G +L Sbjct: 148 IDFGLAKKYRDTSTHQHIPYRENKNLTGTARYASVNTHLGIEQ-SRRDDLESLGYVLMYF 206 Query: 265 IFKREPF--FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFY 309 + P+ + + KI + + E Y F+ Sbjct: 207 LRGSLPWQGLKAGTKKQKYEKISEKKVATSIEALCRGYPTEFASYFH 253 >6BFN-A nrPDB Length = 342 Score = 99.4 bits (246), Expect = 2e-21, Method: Composition-based stats. Identities = 44/259 (16%), Positives = 85/259 (32%), Gaps = 57/259 (22%) Query: 30 VIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDL 89 + + S T ++ E K+G G + V++ V ++ +K LK Sbjct: 14 LCEISRGTHNFSEELKIGEGGFGCVYRAVMRNT--VYAVKRLKE---------------- 55 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 D +T K+ L + H NI+ Sbjct: 56 ------------NADLEWTAVKQSFLTEVE----QLSRFRHPNIVDFAGYCAQNGFYC-- 97 Query: 150 LVFEYVDNVDFRILY-------PKLTDLEIRFYMFELLKALDYCH--SMGIMHRDVKPHN 200 LV+ ++ N P L+ + + +A+ + H S ++H D+K N Sbjct: 98 LVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSN 157 Query: 201 VMIDHKNKKLRLIDWGLAEFYH----------VNMEYNVRVASRFFKGPELLVDYRMYDY 250 V++D + +L D+GLA F + + + PE + Sbjct: 158 VLLDERLTP-KLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYL-PEEYIKTGRLAV 215 Query: 251 SLDLWSFGTMLASMIFKRE 269 D +SFG ++ + + Sbjct: 216 DTDTFSFGVVVLETLAGQR 234 >4BTK-A nrPDB Length = 337 Score = 99.0 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 44/300 (14%), Positives = 102/300 (34%), Gaps = 53/300 (17%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVK-KKKIKREIKILTDLSNEKVPP 96 +++ K+G G + E+++ + L ++ + +K+ + K+ +K E+ +L L Sbjct: 56 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQ------ 109 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 G ++ ++ + + + Sbjct: 110 --------------------------------GKDHVCRFIGCGRNEKFNYVVMQLQGRN 137 Query: 157 NVDFRILYPK--LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM---IDHKNKKLR 211 D R P+ T ++L++++ HS+G +HRD+KP N + +K Sbjct: 138 LADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCY 197 Query: 212 LIDWGLAEFY-------HVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASM 264 ++D+GLA Y + + + M DLWS ML Sbjct: 198 MLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREM-GRHDDLWSLFYMLVEF 256 Query: 265 IFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIN 324 + P + + +Q+ I + K++ +D + + + ++ Sbjct: 257 AVGQLP-WRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMS 315 >4NFN-A nrPDB Length = 309 Score = 98.3 bits (243), Expect = 5e-21, Method: Composition-based stats. Identities = 44/300 (14%), Positives = 102/300 (34%), Gaps = 53/300 (17%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVK-KKKIKREIKILTDLSNEKVPP 96 +++ K+G G + E+++ + L ++ + +K+ + K+ +K E+ +L L Sbjct: 21 DRWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQPKQVLKMEVAVLKKLQ------ 74 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 G ++ ++ + + + Sbjct: 75 --------------------------------GKDHVCRFIGCGRNEKFNYVVMQLQGRN 102 Query: 157 NVDFRILYPK--LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM---IDHKNKKLR 211 D R P+ T ++L++++ HS+G +HRD+KP N + +K Sbjct: 103 LADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCY 162 Query: 212 LIDWGLAEFY-------HVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASM 264 ++D+GLA Y + + + M DLWS ML Sbjct: 163 MLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREM-GRHDDLWSLFYMLVEF 221 Query: 265 IFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIN 324 + P + + +Q+ I + K++ +D + + + ++ Sbjct: 222 AVGQLP-WRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMS 280 >5VC6-A nrPDB Length = 289 Score = 98.3 bits (243), Expect = 5e-21, Method: Composition-based stats. Identities = 52/349 (14%), Positives = 98/349 (28%), Gaps = 103/349 (29%) Query: 37 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPP 96 T ++ K+G G++ VF+ VK IK K Sbjct: 10 TTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKP---------------------- 47 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 D +R H++++ F + + EY + Sbjct: 48 -----------LAGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAE--DDHMLIQNEYCN 94 Query: 157 NVDFRI-------LYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 + + E++ + ++ + L Y HSM ++H D+KP N+ I + Sbjct: 95 GGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIP 154 Query: 210 ------------------LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYS 251 ++ D G V F E+L + + Sbjct: 155 NAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQ---VEEGDSRFLANEVLQENYTHLPK 211 Query: 252 LDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDM 311 D+++ + EP N DQ +I + LPR + Sbjct: 212 ADIFALALTV-VCAAGAEPL---PRNGDQWHEI---------------RQGRLPRIPQVL 252 Query: 312 DQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGH 360 Q E +L+ ++ D + R +A + H Sbjct: 253 SQ---------------------EFTELLKVMIHPDPERRPSAMALVKH 280 >5X18-A nrPDB Length = 295 Score = 96.7 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 42/290 (14%), Positives = 96/290 (33%), Gaps = 53/290 (18%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIK-MLKPVKKKKIKREIKILTDLSNEKVPPTT 98 Y+I K+G G + +F+G + + V + IK + + +++ E K L+ P Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQLRDEYKTYKILNGTPNIPYA 68 Query: 99 LPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNV 158 F ++ + D+L ++ LFD Sbjct: 69 YYFGQEGLHNILVIDLLG--------------PSLEDLFDWCGR---------------- 98 Query: 159 DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK----KLRLID 214 K + + +++ ++ H+ +++RD+KP N +I + + LID Sbjct: 99 -------KFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLID 151 Query: 215 WGLAEFYHVNM--------EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 +G+A+ Y E + + + D+ + G + + Sbjct: 152 FGMAKQYRDPKTKQHIPYREKKSLSGTARYMSINTHLGREQ-SRRDDMEALGHVFFYFLR 210 Query: 267 KREPF--FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQY 314 P+ +N + KI + +++ + R + Sbjct: 211 GHLPWQGLKAPNNKQKYEKIGEKKRSTNVYDLAQGLPVQFGRYLEIVRSL 260 >4L00-A nrPDB Length = 304 Score = 94.8 bits (234), Expect = 5e-20, Method: Composition-based stats. Identities = 57/346 (16%), Positives = 113/346 (32%), Gaps = 90/346 (26%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 KD +GRG + ++ G +D K + +++IK++ + + Sbjct: 25 KDLVQGEHLGRGTRTHIYSGTLMDY---------KDDEGTSEEKKIKVILKVLDPSHRDI 75 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 +L F + Q H +I++L+ + + +V E+V+ Sbjct: 76 SLAFFEAASMMRQ-----------------VSHKHIVYLYGVCVRDVEN--IMVEEFVEG 116 Query: 158 VDFRILYPK----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK---- 209 + + LT +L AL Y ++H +V N+++ + Sbjct: 117 GPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECG 176 Query: 210 --LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 ++L D G+ E R+ + PE + D + + D WSFGT L + + Sbjct: 177 PFIKLSDPGIPITVLSRQECIERI---PWIAPECVEDSKNLSVAADKWSFGTTLWEICYN 233 Query: 268 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGN 327 E + ++ RF Sbjct: 234 GEIPLKDKTLIEK---------------------------------------ERFYESRC 254 Query: 328 KHLSGN-DEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPIREQIEK 372 + ++ + E+ DL+ + YD +R P+F I I K Sbjct: 255 RPVTPSCKELADLMTRCMNYDPNQR---------PFFRAIMRDINK 291 >5UV4-A nrPDB Length = 311 Score = 94.8 bits (234), Expect = 5e-20, Method: Composition-based stats. Identities = 26/165 (15%), Positives = 57/165 (34%), Gaps = 12/165 (7%) Query: 116 KFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDL----- 170 K I H N++ L P ++ +Y D + + Sbjct: 66 KEFSREIKKLGSVRHPNLVPLRGYYWGPKEHERIMISDYADATSLSTYLSEFDERNLPPL 125 Query: 171 ---EIRFYMFELLKALDYCHSMGIM-HRDVKPHNVMIDHKNKKLRLIDWGLAEFYHV--N 224 + ++ + LDY H+ ++ H ++K NV+I + + D+ L Sbjct: 126 SAGQRLNIAIDIARCLDYLHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGM 185 Query: 225 MEYNVRVASRFFKGPELLVDYRMY-DYSLDLWSFGTMLASMIFKR 268 E + + + PE + D+++FG +L ++ + Sbjct: 186 AEQVLNAGALGYSPPEFSSTSKPCPSLKSDVYAFGVILLELLTGK 230 >5FQD-C nrPDB Length = 341 Score = 94.8 bits (234), Expect = 5e-20, Method: Composition-based stats. Identities = 34/238 (14%), Positives = 77/238 (32%), Gaps = 54/238 (22%) Query: 39 DYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTT 98 Y++ K+G G + +++ + + + ++ +K+ Sbjct: 20 KYKLVRKIGSGSFGDIYLAINITNGEEVAVKL---------------------------- 51 Query: 99 LPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD-- 156 + + +L + Y Q G +I + LV + + Sbjct: 52 ------ESQKARHPQLLYESKLYKILQGGVGIPHI-RWYG----QEKDYNVLVMDLLGPS 100 Query: 157 -NVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR--LI 213 F + T + +++ ++Y H+ +HRD+KP N ++ + LI Sbjct: 101 LEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLI 160 Query: 214 DWGLAEFYHVN--------MEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFG-TMLA 262 D+GLA+ Y N E + + + D+ S G ++ Sbjct: 161 DFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQ-SRRDDMESLGYVLMY 217 >5M07-A nrPDB Length = 276 Score = 93.6 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 41/253 (16%), Positives = 78/253 (30%), Gaps = 57/253 (22%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTL 99 Y + +G EV+ +K+L P Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAA---------------------- 69 Query: 100 PFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVD 159 ++ + + H +I+ + D + + +YVD +D Sbjct: 70 -----------DDEFRRRFQRETEVAARLFHPHILEVHD--RGEFDGQLWIAMDYVDGID 116 Query: 160 FRILYPK-----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK---NKKLR 211 L E+ + + ALDY H G++HRDV P NV++ + ++++ Sbjct: 117 ATQHMADRFPAVLPVGEVLAIVTAVAGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRIL 176 Query: 212 LIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 L D+G+A + PEL + D D ++ + P Sbjct: 177 LADFGIASQ-------------PSYPAPELSAGADV-DGRADQYALALTAIHLFAGAPPV 222 Query: 272 FHGTSNTDQLVKI 284 + Q K+ Sbjct: 223 DRSHTGPLQPPKL 235 >5VDK-A nrPDB Length = 297 Score = 92.9 bits (229), Expect = 2e-19, Method: Composition-based stats. Identities = 49/347 (14%), Positives = 104/347 (29%), Gaps = 107/347 (30%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPT 97 K++ K+G G++ V++ +K IK R +K T+LSNE Sbjct: 15 KEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIK-----------RSMKTFTELSNENSA-- 61 Query: 98 TLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN 157 + H +++ + + + EY + Sbjct: 62 --------------------LHEVYAHAVLGHHPHVVRYYSSWAE--DDHMIIQNEYCNG 99 Query: 158 VDFRILYPK-------LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHK---- 206 + + + +++ + ++ L+Y H+ ++H D+KP N+ I HK Sbjct: 100 GSLQAAISENTKSGNHFEEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSE 159 Query: 207 ------------------NKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMY 248 N ++ D G A + + V F E+L + + Sbjct: 160 SSGVIEEVENEADWFLSANVMYKIGDLGHATSIN---KPKVEEGDSRFLANEILQEDYRH 216 Query: 249 DYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREF 308 D+++ G +A G + F Sbjct: 217 LPKADIFALGLTIAV-----------------------AAGAESLPTNGAAWHHIRKGNF 253 Query: 309 YDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAK 355 D+ Q ++ L+ N+++ D ++R +A Sbjct: 254 PDVPQ-----------------ELSESFSSLLKNMIQPDAEQRPSAA 283 >4NT4-A nrPDB Length = 312 Score = 92.5 bits (228), Expect = 2e-19, Method: Composition-based stats. Identities = 60/322 (18%), Positives = 107/322 (33%), Gaps = 62/322 (19%) Query: 39 DYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTT 98 ++ + K+G G + E+ G L + + IK ++P+K K Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIK-MEPMKSKA-------------------- 51 Query: 99 LPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDN- 157 E + D +G I HL + A+V E + Sbjct: 52 --------PQLHLEYRFYKLLGSHADNAPDGIPRIYHL----GTCGGRYNAMVLELLGLS 99 Query: 158 --VDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMI----DHKNKKLR 211 F I K + + +LL ++Y HS +++RDVKP N +I + K + Sbjct: 100 LEDLFNICARKFSLKTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIH 159 Query: 212 LIDWGLAEFY--------HVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLAS 263 +ID+GLA+ Y E+ + + + DL + G M Sbjct: 160 IIDFGLAKEYIDLDTNRHIPYREHKSLTGTARYMSINTHMGREQ-SRRDDLEALGHMFMY 218 Query: 264 MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFI 323 + P + G D L + + +G + + P EF +Y+R+ Sbjct: 219 FLRGSLP-WQGLK-ADTLKERYQKIGDTKRATPIEVLCDGHPEEFATYLRYVRRLDFFET 276 Query: 324 NDGNKHLSGNDEIIDLIDNLLR 345 D D + L + Sbjct: 277 PD-----------YDFLRRLFQ 287 >4TN6-A nrPDB Length = 318 Score = 92.1 bits (227), Expect = 3e-19, Method: Composition-based stats. Identities = 48/319 (15%), Positives = 95/319 (29%), Gaps = 60/319 (18%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKM-LKPVKKKKIKREIKILTDLSNEKVPP 96 Y + K+G G + +++ G + + ++ IK+ K ++ E KI + P Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIP 66 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 T + Y +V E + Sbjct: 67 TIRWCGAEGDYN----------------------------------------VMVMELLG 86 Query: 157 ---NVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM--IDHKNKKLR 211 F K + + +++ ++Y HS +HRDVKP N + + K + Sbjct: 87 PSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVY 146 Query: 212 LIDWGLAEFYHVNMEY--------NVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLAS 263 +ID+GLA+ Y + + + + DL S G +L Sbjct: 147 IIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQ-SRRDDLESLGYVLMY 205 Query: 264 MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFI 323 P + G + K ++ +K E+ + Y+ Sbjct: 206 FNLGSLP-WQGLKAATKRQKYERI----SEKKMSTPIEVLCKGYPSEFATYLNFCRSLRF 260 Query: 324 NDGNKHLSGNDEIIDLIDN 342 +D + +L Sbjct: 261 DDKPDYSYLRQLFRNLFHR 279 >2CMW-A nrPDB Length = 310 Score = 91.7 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 56/317 (17%), Positives = 103/317 (32%), Gaps = 59/317 (18%) Query: 41 EIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLP 100 + K+G G + E+ G L + + IK L+P+K + Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRA---------------------- 39 Query: 101 FQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV--DNV 158 + + L + + G P K A+V E + Sbjct: 40 --PQLHLEYRFYKQLGSAGEGLPQVYYFG-------------PCGKYNAMVLELLGPSLE 84 Query: 159 DFRILYPK-LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK----LRLI 213 D L + T + +LL ++Y HS +++RDVKP N +I + K + +I Sbjct: 85 DLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHII 144 Query: 214 DWGLAEFYHVNM--------EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMI 265 D+GLA+ Y E+ + + + DL + G M + Sbjct: 145 DFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQ-SRRDDLEALGHMFMYFL 203 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 P + G D L + + +G + + P E +Y+R+ + Sbjct: 204 RGSLP-WQGLK-ADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRL---DFFE 258 Query: 326 GNKHLSGNDEIIDLIDN 342 + DL + Sbjct: 259 KPDYEYLRTLFTDLFEK 275 >6EQI-C nrPDB Length = 433 Score = 90.6 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 62/370 (16%), Positives = 121/370 (32%), Gaps = 97/370 (26%) Query: 36 NTKDYEIENKVGRGKYSEVFQGVKLDSK-----VKIVIKMLKPVKKKKIKREIKILTDLS 90 N + ++ + +G + V+ + + ++ +KM+ + I L + Sbjct: 13 NLDELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAI--LKAMY 70 Query: 91 NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKD-------- 142 E VP + F ++ + D + P H NI+ ++ + D Sbjct: 71 RETVPAMSYFFNQNLFNIENISDFKIRLPP---------HPNIVRMYSVFADRIPDLQCN 121 Query: 143 ----PISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFE--------------LLKALD 184 P + P + E L K D ++ Y+ + LL+A+ Sbjct: 122 KQLYPEALPPRINPEGSGRNMSLFLVMKRYDCTLKEYLRDKTPNMRSSILLLSQLLEAVA 181 Query: 185 YCHSMGIMHRDVKPHNVMIDHKNK----KLRLIDWGLAEFYHVNM-------EYNVRVAS 233 + + I HRD+K N+++D + + D+G N E + + Sbjct: 182 HMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGN 241 Query: 234 RFFKGPELLVDYRMYD------YSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKV 287 R PE + + + DLW+ G + + PF+ K +K+ Sbjct: 242 RALMAPE-IANAKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYD---------KTMKL 291 Query: 288 LGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYD 347 L S E+ L + T+P I +L+ N+L Sbjct: 292 LSKSYKEEDLPELPDTIPFI----------------------------IRNLVSNMLSRS 323 Query: 348 HQERLTAKEA 357 +RL A Sbjct: 324 TNKRLDCDVA 333 >5USZ-A nrPDB Length = 289 Score = 89.8 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 44/340 (12%), Positives = 109/340 (32%), Gaps = 103/340 (30%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSK-------VKIVIKMLKPVKK---KKIKREIK 84 +D +G+G ++++F+GV+ + ++++K+L + + Sbjct: 5 IRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAAS 64 Query: 85 ILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPI 144 +++ LS H +++ + + Sbjct: 65 MMSKLS---------------------------------------HKHLVLNYGVC--VC 83 Query: 145 SKTPALVFEYVDNVDFRILYPK----LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHN 200 LV E+V K + L +L A+ + ++H +V N Sbjct: 84 GDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAAAMHFLEENTLIHGNVCAKN 143 Query: 201 VMIDHKNKK-------LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLD 253 +++ + + ++L D G++ R+ + PE + + + + + D Sbjct: 144 ILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERI---PWVPPECIENPKNLNLATD 200 Query: 254 LWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQ 313 WSFGT L + + + +L + Y ++++ P+ Sbjct: 201 KWSFGTTLWEICSGGDKPLSALDSQRKL------------QFYEDRHQLPAPK------- 241 Query: 314 YIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLT 353 E+ +LI+N + Y+ R + Sbjct: 242 -------------------AAELANLINNCMDYEPDHRPS 262 >2C47-A nrPDB Length = 313 Score = 89.8 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 51/315 (16%), Positives = 100/315 (31%), Gaps = 57/315 (18%) Query: 39 DYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTT 98 ++ + K+G G + E+ G L + + IK+ E + Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKL---------------------EPIKSRA 43 Query: 99 LPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD-- 156 + + Q + Y F P K A+V E + Sbjct: 44 PQLHLEYRFYKQLSATEGVPQVYYFG------------------PCGKYNAMVLELLGPS 85 Query: 157 -NVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK----LR 211 F + T + +L+ ++Y H+ +++RDVKP N ++ K + Sbjct: 86 LEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIH 145 Query: 212 LIDWGLAEFYHVNM--------EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLAS 263 +ID+GLA+ Y E+ + + + DL + G M Sbjct: 146 IIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQ-SRRDDLEALGHMFMY 204 Query: 264 MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFI 323 + P + G D L + + +G + + P E +Y+R+ Sbjct: 205 FLRGSLP-WQGLK-ADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEK 262 Query: 324 NDGNKHLSGNDEIID 338 D + ++ D Sbjct: 263 PDYDYLRKLFTDLFD 277 >4XHH-A nrPDB Length = 403 Score = 89.8 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 49/313 (15%), Positives = 103/313 (32%), Gaps = 54/313 (17%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK-KKIKREIKILTDLSNEKVPP 96 + + I K+G G + +++ G L S ++ I++ + ++ E ++ LS P Sbjct: 7 RKFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYKYLSGGVGIP 66 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 F ++ Y D+L +F+ H Sbjct: 67 FIRWFGREGEYNAMVIDLLGPSLEDLFNYCH----------------------------- 97 Query: 157 NVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM--IDHKNKKLRLID 214 K + + +++ + Y H +HRD+KP N + + + + +ID Sbjct: 98 --------RKFSFKTVIMLALQMICRVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVID 149 Query: 215 WGLAEFYHVNMEY--------NVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 +GL++ Y + + + + DL S G ML Sbjct: 150 FGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTHLGIEQ-SRRDDLESLGYMLIYFCK 208 Query: 267 KREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDG 326 P + G T + K ++L +K + E + +Y+ + ++ Sbjct: 209 GSLP-WQGLKATTKKQKYDRIL----EKKLCISVETLCAGLPLEFSEYMNYCRNLKFDER 263 Query: 327 NKHLSGNDEIIDL 339 +L DL Sbjct: 264 PDYLYLARLFKDL 276 >2CHL-A nrPDB Length = 351 Score = 89.0 bits (219), Expect = 3e-18, Method: Composition-based stats. Identities = 57/319 (17%), Positives = 105/319 (32%), Gaps = 61/319 (19%) Query: 39 DYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTT 98 ++ + K+G G + E+ G L + + IK L+P+K + Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPMKSRA-------------------- 69 Query: 99 LPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV--D 156 + Y F + I ++ P K A+V E + Sbjct: 70 ----------------PQLHLEYRFYKQLGSGDGIPQVYYF--GPCGKYNAMVLELLGPS 111 Query: 157 NVDFRILYPK-LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK----LR 211 D L + + + +L+ ++Y HS +++RDVKP N +I K + Sbjct: 112 LEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIH 171 Query: 212 LIDWGLAEFYHVNM--------EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLAS 263 +ID+ LA+ Y E+ + + + DL + G M Sbjct: 172 IIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQ-SRRDDLEALGHMFMY 230 Query: 264 MIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFI 323 + P + G D L + + +G + K E+ F +M Y+R Sbjct: 231 FLRGSLP-WQGLK-ADTLKERYQKIGDT---KRATPIEVLC-ENFPEMATYLRYVRRLDF 284 Query: 324 NDGNKHLSGNDEIIDLIDN 342 + + DL D Sbjct: 285 FEKPDYDYLRKLFTDLFDR 303 >4XHL-A nrPDB Length = 394 Score = 86.7 bits (213), Expect = 1e-17, Method: Composition-based stats. Identities = 45/315 (14%), Positives = 101/315 (32%), Gaps = 58/315 (18%) Query: 38 KDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKK-KKIKREIKILTDLSNEKVPP 96 + + I K+G G + +++ G L S ++ I++ + ++ E ++ LS P Sbjct: 7 RKFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQLDYESRVYRYLSGGVGIP 66 Query: 97 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVD 156 F ++ Y D+L +F+ H Sbjct: 67 FIRWFGREGEYNAMVIDLLGPSLEDLFNYCH----------------------------- 97 Query: 157 NVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM--IDHKNKKLRLID 214 + + + ++ + Y H +HRD+KP N + + + + +ID Sbjct: 98 --------RRFSFKTVIMLALQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVID 149 Query: 215 WGLAEFYHVNMEY--------NVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 +GL++ Y + + + + DL S G +L Sbjct: 150 FGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTHLGIEQ-SRRDDLESLGYVLIYFCK 208 Query: 267 KREPF--FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIN 324 P+ T+ + +I++ K + E + +Y+ + + Sbjct: 209 GSLPWQGLKATTKKQKYDRIMEK-------KLNVSVETLCSGLPLEFQEYMAYCKNLKFD 261 Query: 325 DGNKHLSGNDEIIDL 339 + +L DL Sbjct: 262 EKPDYLFLARLFKDL 276 >1CSN-A nrPDB Length = 298 Score = 85.9 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 47/301 (15%), Positives = 98/301 (32%), Gaps = 57/301 (18%) Query: 40 YEIENKVGRGKYSEVFQGVKLDSKVKIVIK-MLKPVKKKKIKREIKILTDLSNEKVPPTT 98 Y++ ++G G + +F+G L + ++ IK + +++ E + L+ P Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQLRDEYRTYKLLAGCTGIPNV 71 Query: 99 LPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNV 158 F ++ + D+L ++ L D+ Sbjct: 72 YYFGQEGLHNVLVIDLLG--------------PSLEDLLDLCGR---------------- 101 Query: 159 DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK----LRLID 214 K + + ++L + H +++RD+KP N +I N K + ++D Sbjct: 102 -------KFSVKTVAMAAKQMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVD 154 Query: 215 WGLAEFYHVNM--------EYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIF 266 +G+ +FY + E + + + DL + G + + Sbjct: 155 FGMVKFYRDPVTKQHIPYREKKNLSGTARYMSINTHLGREQ-SRRDDLEALGHVFMYFLR 213 Query: 267 KREPF--FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIN 324 P+ +N + +I G L + P EFY Y R Sbjct: 214 GSLPWQGLKAATNKQKYERI----GEKKQSTPLRELCAGFPEEFYKYMHYARNLAFDATP 269 Query: 325 D 325 D Sbjct: 270 D 270 >3REP-A nrPDB Length = 271 Score = 85.6 bits (210), Expect = 3e-17, Method: Composition-based stats. Identities = 33/234 (14%), Positives = 83/234 (35%), Gaps = 31/234 (13%) Query: 120 PYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPK-----LTDLEIRF 174 H N++ + + P + P L+ ++ + + + + Sbjct: 56 EECPRLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVK 115 Query: 175 YMFELLKALDYCHSMG-IMHR-DVKPHNVMIDHK-NKKLRLIDWGLAEFYHVNMEYNVRV 231 + ++ + + + H++ ++ R + +VMID ++ + D + + R+ Sbjct: 116 FALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMAD------VKFSFQSPGRM 169 Query: 232 ASRFFKGPELLVDYRMYD--YSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLG 289 + + PE L S D+WSF +L ++ + PF SN + +K+ Sbjct: 170 YAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPF-ADLSNMEIGMKV----- 223 Query: 290 TSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNL 343 E P + ++ K +N+ D I+ +++ + Sbjct: 224 ---------ALEGLRPTIPPGISPHVSKLMKICMNEDPAKRPKFDMIVPILEKM 268 >4IX6-A nrPDB Length = 350 Score = 82.9 bits (203), Expect = 2e-16, Method: Composition-based stats. Identities = 62/369 (16%), Positives = 112/369 (30%), Gaps = 62/369 (16%) Query: 24 WDYENTVIDWSTNTKDYEIEN-KVGRGKYSEVFQGVKLDSKVKIVIKMLKPV---KKKKI 79 + KD + +G G + VF+GV +V+K K ++ + Sbjct: 5 GGPKTLRRTPGVEPKDIRVLPGPLGSGNFGTVFRGVFK-GDQDVVLKNAKADVMAAEELL 63 Query: 80 KREIKILTDLS-NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFD 138 + E+ + + N K + + E + ++ N N + + Sbjct: 64 ECEMDVNYHVHANAKGTCARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTV---E 120 Query: 139 IIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKP 198 + + A D + + M ELL +L H G++HRDVKP Sbjct: 121 ALMRRGTAPLATAMACADATELGVTKKA---------MRELLGSLARLHECGVVHRDVKP 171 Query: 199 HNVMIDHK-NKKLRLIDWGLAEFYHVNMEY------NVRVASRFFKGPELLVDYRMYDYS 251 N++ K L+LID G A E + R+ K EL + Sbjct: 172 ANLIAAEKDGGVLKLIDLGAAALCLPLPETLNYYPGDGPADPRYAKADELYLLPPGSPRP 231 Query: 252 L----------------DLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEK 295 D WS G ++ + + ++ + K +G Sbjct: 232 TKDNAAKLWEAHKPDRFDSWSAGCVMLQLAVVGL---RTDAGLERFLADYKAVGYDVNAF 288 Query: 296 YLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAK 355 K +F +D W DL L+ + R + + Sbjct: 289 RGEKSGEYGTMDFAALDANGGAGW------------------DLCQRLMEAERDARASCE 330 Query: 356 EAMGHPWFA 364 A+ H +F Sbjct: 331 AALSHAFFD 339 >6J6I-B nrPDB Length = 351 Score = 81.7 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 37/176 (21%), Positives = 64/176 (36%), Gaps = 18/176 (10%) Query: 108 TNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRIL---- 163 T ++ V + + + H+N + L + P LVFE+ ++ Sbjct: 95 TGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLEFP--FPVLVFEFAEHGAMNQRGGVI 152 Query: 164 ---YPKLTDLEIRF-YMFELLKALDYCHS---MGIMHRDVKPHNVMIDHKNKKLRLIDWG 216 L +R E+ A+ Y H+ I+HRDVKP +V +D KN +L D Sbjct: 153 VNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLD-KNWTAKLSDLS 211 Query: 217 LAEFYHVNMEYNVR---VASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 269 + + + + P L D++SFG L +I + Sbjct: 212 FSISLPEGKSRIEAEWVLGTFGYIDP-LYHKTCFVTEYTDVYSFGICLLVIITGKP 266 >5C01-A nrPDB Length = 342 Score = 79.8 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 45/337 (13%), Positives = 97/337 (28%), Gaps = 66/337 (19%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 93 + K+ + +G+G + V++G ++ K+ E ++ + Sbjct: 54 RVDQKEITQLSHLGQGTRTNVYEGRLRVEGS-------GDPEEGKMDDEDPLVPGRDRGQ 106 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 L + D+ H ++ + + +V E Sbjct: 107 ELRVVLKVLDPSH-----HDIALAFYETASLMSQVSHTHLAFVHGVCVRGPEN--IMVTE 159 Query: 154 YVDNVDF----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 YV++ R + +L AL Y + ++H +V N+++ Sbjct: 160 YVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLA 219 Query: 210 ------LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDY-RMYDYSLDLWSFGTMLA 262 ++L D G+ E R+ + PE L ++D W FG L Sbjct: 220 EGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGATLL 276 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 + F E S +++ FY + +P Sbjct: 277 EICFDGEAPLQSRSPSEK-------------------------EHFYQRQHRLPEP---- 307 Query: 323 INDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMG 359 ++ L L Y+ +R + + + Sbjct: 308 ---------SCPQLATLTSQCLTYEPTQRPSFRTILR 335 >4WOV-A nrPDB Length = 317 Score = 79.4 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 45/337 (13%), Positives = 97/337 (28%), Gaps = 66/337 (19%) Query: 34 STNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEK 93 + K+ + +G+G + V++G ++ K+ E ++ + Sbjct: 31 RVDQKEITQLSHLGQGTRTNVYEGRLRVEGS-------GDPEEGKMDDEDPLVPGRDRGQ 83 Query: 94 VPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFE 153 L + D+ H ++ + + +V E Sbjct: 84 ELRVVLKVLDPSH-----HDIALAFYETASLMSQVSHTHLAFVHGVCVRGPEN--IMVTE 136 Query: 154 YVDNVDF----RILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 209 YV++ R + +L AL Y + ++H +V N+++ Sbjct: 137 YVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLA 196 Query: 210 ------LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDY-RMYDYSLDLWSFGTMLA 262 ++L D G+ E R+ + PE L ++D W FG L Sbjct: 197 EGTSPFIKLSDPGVGLGALSREERVERI---PWLAPECLPGGANSLSTAMDKWGFGATLL 253 Query: 263 SMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRF 322 + F E S +++ FY + +P Sbjct: 254 EICFDGEAPLQSRSPSEK-------------------------EHFYQRQHRLPEP---- 284 Query: 323 INDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMG 359 ++ L L Y+ +R + + + Sbjct: 285 ---------SCPQLATLTSQCLTYEPTQRPSFRTILR 312 >5CLR-A nrPDB Length = 451 Score = 73.6 bits (179), Expect = 1e-13, Method: Composition-based stats. Identities = 27/146 (18%), Positives = 56/146 (38%), Gaps = 15/146 (10%) Query: 135 HLFDIIKDPISKTPALVFEYVDNVDFRILYPKLT-------DLEIRFYMFELLKALDYCH 187 L + ++ ++ ++ +D L E+ M + + H Sbjct: 134 RLVGTFFNEQTQVHYILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFH 193 Query: 188 SMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPEL--LVDY 245 +G++HRD+KP N+M+D + + L+D+G + + + PEL D+ Sbjct: 194 ELGLIHRDLKPGNIMLDA-DMQCHLVDFGSSS--SDKEPKPASWGTASYLAPELNAQEDF 250 Query: 246 RMYDYSLDLWSFGTMLASMIFKREPF 271 + DL++ S+ PF Sbjct: 251 IAFSQVSDLFAL---AYSLDELFNPF 273 >5UU1-A nrPDB Length = 324 Score = 72.1 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 37/262 (14%), Positives = 86/262 (32%), Gaps = 39/262 (14%) Query: 26 YENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKK--IKREI 83 E V+D + + K+G G + ++ + K ++K ++ + E+ Sbjct: 5 PEGKVLD-DMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSEL 63 Query: 84 KILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDP 143 K +KD + L ++ +F + + Sbjct: 64 K-----------FYQRVAKKDCIKKWIERKQLDYLGIPLFYGS-----------GLTEFK 101 Query: 144 ISKTPALVFEYVDNVDFRILYPK---LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHN 200 +V E + +D + + + + +L L+Y H +H D+K N Sbjct: 102 GRSYRFMVMERL-GIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAAN 160 Query: 201 VMIDHKNK-KLRLIDWGLAEFYHVNMEYNVRV--------ASRFFKGPELLVDYRMYDYS 251 +++ +KN ++ L D+GL+ Y N + + F + + Sbjct: 161 LLLGYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVAL-SRR 219 Query: 252 LDLWSFGTMLASMIFKREPFFH 273 D+ G + + + P+ Sbjct: 220 SDVEILGYCMLRWLCGKLPWEQ 241 >6G4J-A nrPDB Length = 315 Score = 71.7 bits (174), Expect = 5e-13, Method: Composition-based stats. Identities = 49/286 (17%), Positives = 92/286 (32%), Gaps = 44/286 (15%) Query: 32 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSN 91 W+ NT Y + ++G+G V+ D + +K+ I E+ +L S Sbjct: 22 KWNGNT--YTLRKQLGKGANGIVYLAETSDGH--VALKV--SDDSLSITSEVNVLKSFSK 75 Query: 92 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 151 + F I +K Sbjct: 76 AQSVTMGPSFFDTDDA-------------------------------YIPSANTKVSFYA 104 Query: 152 FEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLR 211 EY+ I M +LL +L H G + D+KP N+++ ++R Sbjct: 105 MEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIR 164 Query: 212 LIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPF 271 ID G ++ R + G R + S DL++ ++ + + K+E F Sbjct: 165 CIDVGGTTKEGRAIKEYTEFYDRGYWG----YGTRKAEPSYDLFAVAMIMINSVHKKE-F 219 Query: 272 FHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRK 317 +QL +++ G +KY L ++ D+ + Sbjct: 220 KKTNQPKEQLRSLIE--GNPLLQKYKKALFSALNGDYQSADEMKKD 263 >4L68-A nrPDB Length = 340 Score = 70.9 bits (172), Expect = 9e-13, Method: Composition-based stats. Identities = 29/164 (17%), Positives = 57/164 (34%), Gaps = 16/164 (9%) Query: 116 KFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLT---DLEI 172 + R + H+N+ L + + LV++Y+ N L D Sbjct: 80 REFRYEMNQLWELRHSNLAPLLGFC--VVEEEKFLVYKYMSNGTLHSLLDSNRGELDWST 137 Query: 173 RFYM-FELLKALDYCHSMG---IMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNME-- 226 RF + + L + H I+H+++ ++ID ++ R+ID GLA + Sbjct: 138 RFRIGLGAARGLAWLHHGCRPPILHQNICSSVILID-EDFDARIIDSGLARLMVPSDNNE 196 Query: 227 ---YNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 + + PE D++ G +L + Sbjct: 197 SSFMTGDLGEFGYVAPEYSTTMLA-SLKGDVYGLGVVLLELATG 239 >5DMZ-A nrPDB Length = 365 Score = 70.1 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 43/278 (15%), Positives = 96/278 (34%), Gaps = 59/278 (21%) Query: 15 INKQRTEEYWDYENTVIDWSTNTKDYEIENKV-------GRGKYSEVFQGV-----KLDS 62 ++ W + I ++++ +K+ G G +++V++ + Sbjct: 38 VSSYPNTFEWQCKLPAIK---PKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKN 94 Query: 63 KVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYI 122 K K V+K+ KP + +++ L P F K + + Y Sbjct: 95 KQKFVLKVQKPANPWEFYIGTQLMERLK----PSMQHMFMKFYSAHLFQNGSVLVGELYS 150 Query: 123 FDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKA 182 + N I+L+ TP V ++ + + ++ Sbjct: 151 YGTLL----NAINLY-------KNTPEKVM---PQGLVISFAMRM-----LYMIEQV--- 188 Query: 183 LDYCHSMGIMHRDVKPHNVMI----------DHKNKKLRLIDWGLA---EFYHVNMEYNV 229 H I+H D+KP N ++ D + L LID G + + + + Sbjct: 189 ----HDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTA 244 Query: 230 RVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 267 + + F+ E+L + + ++Y +D + + M+F Sbjct: 245 KCETSGFQCVEMLSN-KPWNYQIDYFGVAATVYCMLFG 281 >4CI6-B nrPDB Length = 643 Score = 69.4 bits (168), Expect = 2e-12, Method: Composition-based stats. Identities = 33/143 (23%), Positives = 52/143 (36%), Gaps = 19/143 (13%) Query: 128 NGHANIIHLFDIIKDPISKTPA--LVFEYVDNVDFRILYPKLTDL-------------EI 172 H N+ ++ + P L+ + VD L D I Sbjct: 99 GKHPNLANVHGMAVVPYGNRYYYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTI 158 Query: 173 RFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVA 232 +F LL ++ GI+H D+KP NV+ D + + +ID GL H + Sbjct: 159 KFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGL----HSRSGEQPKGF 214 Query: 233 SRFFKGPELLVDYRMYDYSLDLW 255 + FK PEL V D++ Sbjct: 215 TESFKAPELGVGNLGASEKSDVF 237 >2RSV-A nrPDB Length = 403 Score = 65.5 bits (158), Expect = 3e-11, Method: Composition-based stats. Identities = 43/316 (13%), Positives = 100/316 (31%), Gaps = 50/316 (15%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKI-----VIKMLKPVKKKKIKREIKILTDL 89 K++++ +G+G + ++ ++S + + ++P + E+K Sbjct: 39 MAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 97 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 + + + +K +Y K H Sbjct: 98 AKPEQIQKWIRTRKLKYLGVPKY------------WGSGLH----------DKNGKSYRF 135 Query: 150 LVFEYVDNVDFRILY----PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 ++ + D + +Y + + + +L L+Y H +H D+K N+++++ Sbjct: 136 MIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 194 Query: 206 KNK-KLRLIDWGLAEFYHVNMEYNVRV--------ASRFFKGPELLVDYRMYDYSLDLWS 256 KN ++ L+D+GLA Y + + F + DL Sbjct: 195 KNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEI 253 Query: 257 FGTMLASMIFKREPFFHGTSNTD-------QLVKIVKVLGTSDFEKYLLKYEITLPREFY 309 G + + P+ + + + + L F + EI E Sbjct: 254 LGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETV 313 Query: 310 DMDQYIRKPWHRFIND 325 + Y KP + + D Sbjct: 314 KLLDYTEKPLYENLRD 329 >2JII-A nrPDB Length = 352 Score = 65.1 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 25/126 (19%), Positives = 51/126 (40%), Gaps = 10/126 (7%) Query: 167 LTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN-KKLRLIDWGLAEFYHVNM 225 L++ + LL AL++ H +H +V N+ +D ++ ++ L +G A Y + Sbjct: 156 LSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSG 215 Query: 226 EYNVRV--------ASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSN 277 ++ V F +L DL S G + ++ P+ + N Sbjct: 216 KHVAYVEGSRSPHEGDLEFISMDLHKGCGP-SRRSDLQSLGYCMLKWLYGFLPWTNCLPN 274 Query: 278 TDQLVK 283 T+ ++K Sbjct: 275 TEDIMK 280 >2LAV-A nrPDB Length = 361 Score = 64.8 bits (156), Expect = 6e-11, Method: Composition-based stats. Identities = 43/316 (13%), Positives = 100/316 (31%), Gaps = 50/316 (15%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKI-----VIKMLKPVKKKKIKREIKILTDL 89 K++++ +G+G + ++ ++S + + ++P + E+K Sbjct: 32 MAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 Query: 90 SNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA 149 + + + +K +Y K H Sbjct: 91 AKPEQIQKWIRTRKLKYLGVPKY------------WGSGLH----------DKNGKSYRF 128 Query: 150 LVFEYVDNVDFRILY----PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 ++ + D + +Y + + + +L L+Y H +H D+K N+++++ Sbjct: 129 MIMDRF-GSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 Query: 206 KNK-KLRLIDWGLAEFYHVNMEYNVRV--------ASRFFKGPELLVDYRMYDYSLDLWS 256 KN ++ L+D+GLA Y + + F + DL Sbjct: 188 KNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAP-SRRGDLEI 246 Query: 257 FGTMLASMIFKREPFFHGTSNTD-------QLVKIVKVLGTSDFEKYLLKYEITLPREFY 309 G + + P+ + + + + L F + EI E Sbjct: 247 LGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETV 306 Query: 310 DMDQYIRKPWHRFIND 325 + Y KP + + D Sbjct: 307 KLLDYTEKPLYENLRD 322 >4I94-A nrPDB Length = 300 Score = 62.4 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 54/305 (17%), Positives = 104/305 (34%), Gaps = 80/305 (26%) Query: 53 EVFQGVKLDSKVKIVIKMLKPV---KKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTN 109 V++G KL+++ +I +K ++ E K + L N ++ + Sbjct: 44 VVYKG-KLENQRRIAVKRFNRKSWPDSRQFLEEAKAVGQLRNHRMA--------NLLGCC 94 Query: 110 QKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTD 169 +++ I ++ ++ H LF P+ L Sbjct: 95 YEDEERLLIAEFMPNETLAKH-----LFHWESQPMKWAMRL------------------- 130 Query: 170 LEIRFYMFELLKALDYCHSMG-IMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYN 228 + +AL+YC S G ++ D+ + V+ D + RL +GL + Y+ Sbjct: 131 ----RVALHIAQALEYCTSKGRALYHDLNAYRVLFD-DDANPRLSCFGLMKNSRDGKSYS 185 Query: 229 VRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE-PFFHGTSNTDQLVKIVKV 287 +A F PE L R+ ++SFGT+L ++ + P H + +++ Sbjct: 186 TNLA---FTPPEYLRTGRV-TPESVIYSFGTLLLDLLSGKHIPPSHALDL--IRDRNIQM 239 Query: 288 LGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYD 347 L S E + T E+I L L+Y+ Sbjct: 240 LMDSGLEGQFSSDDGT-------------------------------ELIRLASRCLQYE 268 Query: 348 HQERL 352 +ER Sbjct: 269 PRERP 273 >6G38-A nrPDB Length = 357 Score = 55.1 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 44/226 (19%), Positives = 75/226 (33%), Gaps = 43/226 (19%) Query: 35 TNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLK-------PVKKKKIKREI---- 83 T+ + K+G G + EVFQ + + IK++ +K EI Sbjct: 38 LPTEKLQRCEKIGEGVFGEVFQTI--ADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEI 95 Query: 84 ---KILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII 140 K L+ LS E T + + Q ++ + G AN D Sbjct: 96 IISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSAN--DRPDFF 153 Query: 141 KDPISKTPALVFEYVDNV-DFRILYPKLTDL-EIRFYMFELLKALDYCH-SMGIMHRDVK 197 KD +V E+ D + KL+ L + + +L +L S+ HRD+ Sbjct: 154 KD---DQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLH 210 Query: 198 PHNVM-------------------IDHKNKKLRLIDWGLAEFYHVN 224 NV+ I ++ +ID+ L+ Sbjct: 211 WGNVLLKKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDG 256 >6EWX-A nrPDB Length = 484 Score = 54.0 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 31/233 (13%), Positives = 66/233 (28%), Gaps = 78/233 (33%) Query: 165 PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK--------------- 209 P++ + + F + +L L++ GI+HRD+ N+++ H N + Sbjct: 205 PEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSVPTTT 264 Query: 210 -------------------------LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVD 244 L + ++ A+ + S+ PE++ Sbjct: 265 SRCPSAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPEIVSA 324 Query: 245 YRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITL 304 + D + G ++ ++ + PF QL + Sbjct: 325 SQY--RKFDEFQTGILIYELLHQPNPF----EVRAQLRE--------------------- 357 Query: 305 PREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEA 357 R + + + L LL D +R+ EA Sbjct: 358 -----------RDYRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRIRIGEA 399 >4O1O-A nrPDB Length = 717 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 33/159 (20%), Positives = 54/159 (33%), Gaps = 11/159 (6%) Query: 67 VIKMLKPVKKKKI-KREIKILTDLS----NEKVPPTTLPFQKDQYYTNQKEDVLKFIRPY 121 +K L + + I K +I I + E L ++ E + + Sbjct: 329 ALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLYEDQEVAVKRFSEGSTRGQQEV 388 Query: 122 IFDQPHNGHANIIHLFDIIKDPISKTPALVF-EYVDNVDFRILY----PKLTDLEIRFYM 176 Q + N++ + D L EY P D R + Sbjct: 389 SCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNIL 448 Query: 177 FELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDW 215 L KA+ H G H+D++P N++ID KN L D+ Sbjct: 449 SSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTF-LADF 486 Score = 29.3 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 11/42 (26%), Positives = 22/42 (52%), Gaps = 4/42 (9%) Query: 331 SGNDEIIDLIDNLLR--YDHQERLTAKEAMGHPWFAPIREQI 370 S ++E DLI +L + ++RL++ + HP+F + Sbjct: 536 SPDEETRDLIHHLFHPGDNVEDRLSS--LLAHPFFWSWESRY 575 >6M7Z-A nrPDB Length = 319 Score = 52.4 bits (124), Expect = 3e-07, Method: Composition-based stats. Identities = 35/218 (16%), Positives = 69/218 (31%), Gaps = 66/218 (30%) Query: 168 TDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEY 227 + +++ ++ AL H++G++HR ++ N + + L GL + E Sbjct: 142 SHPDVQVLAANMVAALKSLHNLGLLHRSIEL-NSFSVLPDGTVVLG--GLDTAAPIGTET 198 Query: 228 NVRVASRFF---KGPEL--------LVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTS 276 + V FF PE+ + + D++S G Sbjct: 199 RLWVG--FFGQETAPEIDRNFLADLALTQGRHTVKSDVYSLGV----------------- 239 Query: 277 NTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEI 336 +V++LG + D + E+ Sbjct: 240 ---AFRNLVQLLGNGNL----------------------------GPEDRGAVRQDHLEL 268 Query: 337 ID-LIDNLLRYDHQERLTAKEAMGHPWFAPIR-EQIEK 372 +D L ++ + R T +E M P F + E IE+ Sbjct: 269 LDKLSQKMIEEEPGNRPTIEEIMKDPLFEGLNFEDIEE 306 >3Q60-A nrPDB Length = 371 Score = 51.7 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 53/375 (14%), Positives = 115/375 (30%), Gaps = 39/375 (10%) Query: 3 CRVWSEARVYTNINKQRTEEYWDYENTVID--WSTNTKDYEIENKVGRGKYSEVFQGVKL 60 CR + + + T +D S + ++ + G S VF + Sbjct: 25 CREEALKEPAAMVEAVTATVWPQNAETTVDSLLSQGERKLKLVEPLRVGDRSVVFLVRDV 84 Query: 61 DSKVKIVIKMLKPVKKKKIKREIKILTDLS--NEKVPPTTLPFQKDQYYTNQKEDVLKFI 118 + +K+ + + + E++ L + + ++ + +D+ D + Sbjct: 85 ERLEDFALKVFT-MGAENSRSELERLHEATFAAARLLGESPEEARDRRRLLLPSDAVAVQ 143 Query: 119 RPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFE 178 F Q G + + + + + + L + + L + + Sbjct: 144 SQPPFAQLSPGQDD-YAVANYLLLMPAASVDLELLFSTLDFVYVFRGDEGILALHILTAQ 202 Query: 179 LLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKG 238 L++ S G++H P N+ I + +L L D ++ + V + Sbjct: 203 LIRLAANLQSKGLVHGHFTPDNLFI-MPDGRLMLGD--VSALWKVGTRGPASSVPVTYAP 259 Query: 239 PELL-VDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYL 297 E L + ++L+ W G + + PF L T + Sbjct: 260 REFLNASTATFTHALNAWQLGLSIYRVWCLFLPF---------------GLVTPGIKGSW 304 Query: 298 LKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEA 357 + + +P D + LI L +D + RL EA Sbjct: 305 KRPSLRVP--------------GTDSLAFGSCTPLPDFVKTLIGRFLNFDRRRRLLPLEA 350 Query: 358 MGHPWFAPIREQIEK 372 M P F ++ +I Sbjct: 351 METPEFLQLQNEISS 365 >4AZV-A nrPDB Length = 569 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 20/68 (29%), Positives = 33/68 (48%), Gaps = 1/68 (1%) Query: 149 ALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK 208 LV E + + +++ + LL++L G H DV+P NVM+D + + Sbjct: 318 WLVMEKLPGRLLSDMLAAGEEIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMVDAR-Q 376 Query: 209 KLRLIDWG 216 RLID+G Sbjct: 377 HARLIDFG 384 Score = 29.7 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 11/51 (21%), Positives = 20/51 (39%), Gaps = 1/51 (1%) Query: 259 TMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFY 309 +L + K EPF+ G S D ++++ + +PR Y Sbjct: 170 VIL-ELAVKEEPFYWGVSQPDDPRELIEQCAFYRLIGEFDTHLSPVPRPMY 219 >4AZW-A nrPDB Length = 471 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 20/68 (29%), Positives = 33/68 (48%), Gaps = 1/68 (1%) Query: 149 ALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNK 208 LV E + + +++ + LL++L G H DV+P NVM+D + + Sbjct: 318 WLVMEKLPGRLLSDMLAAGEEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVDAR-Q 376 Query: 209 KLRLIDWG 216 RLID+G Sbjct: 377 HARLIDFG 384 Score = 29.7 bits (65), Expect = 2.2, Method: Composition-based stats. Identities = 11/51 (21%), Positives = 20/51 (39%), Gaps = 1/51 (1%) Query: 259 TMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFY 309 +L + K EPF+ G S D ++++ + +PR Y Sbjct: 170 VIL-ELAVKEEPFYWGVSQPDDPRELIEQCAFYRLIGEFDTHLSPVPRPMY 219 >5YK0-A nrPDB Length = 452 Score = 50.5 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 27/173 (15%), Positives = 69/173 (39%), Gaps = 15/173 (8%) Query: 52 SEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLS------NEKVPPTTLPFQKDQ 105 +V + + D + + +K+ P + ++ ++K + + + + + + Sbjct: 146 GQVHKAIWSDGRE-VAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVE 204 Query: 106 YYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYP 165 + + L+ F + ++ H F + S ++ E+++ V + Sbjct: 205 RTEMELDYRLEAANQRAFAKAYHDHPR----FQVPHVVASAPKVVIQEWIEGVPMAEIIR 260 Query: 166 KLTDLEIRFYMFELLKALDYCH--SMGIMHRDVKPHNVMIDHKNKKLRLIDWG 216 T + R + LL L + +G+MH D P N M+ + ++ +ID+G Sbjct: 261 HGTTEQ-RDLIGTLLAELTFDAPRRLGLMHGDAHPGNFML-LPDGRMGIIDFG 311 >6BHC-A nrPDB Length = 438 Score = 50.1 bits (118), Expect = 1e-06, Method: Composition-based stats. Identities = 31/212 (14%), Positives = 61/212 (28%), Gaps = 57/212 (26%) Query: 165 PKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVN 224 P L + ++ + +L L++ + H D++ N+++ H +G AE + Sbjct: 173 PDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLRLENLLLVHYQPGGTAQGFGPAEPTPTS 232 Query: 225 MEYNVRVAS-------------RFF------KGPELLVDYRMYDYSLDLWSFGTMLASMI 265 + S PE++ + D + G ++ M+ Sbjct: 233 SYPTRLIVSNFSQAKQKSHLVDPEILRDQSRLAPEIITATQY--KKCDEFQTGILIYEML 290 Query: 266 FKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFIND 325 PF N + L Y R P+ + Sbjct: 291 HLPNPF---DENPE------------------------LKEREYTRADLPRIPFRSPYSR 323 Query: 326 GNKHLSGNDEIIDLIDNLLRYDHQERLTAKEA 357 G + L LL + ER+ +A Sbjct: 324 G---------LQQLASCLLNPNPSERILISDA 346 >5VE6-A nrPDB Length = 492 Score = 49.0 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 10/37 (27%), Positives = 21/37 (56%) Query: 169 DLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDH 205 + + F + +L L++ GI+HRD+ N+++ H Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVH 243 Score = 33.2 bits (74), Expect = 0.20, Method: Composition-based stats. Identities = 19/137 (13%), Positives = 39/137 (28%), Gaps = 22/137 (16%) Query: 237 KGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKY 296 PE++ + D + G ++ ++ + PF ++ L D+ + Sbjct: 325 LAPEIVSASQY--RKFDEFQTGILIYELLHQPNPF-----------EVRAQLRERDYRQE 371 Query: 297 LLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLI---DNLLRYDHQERLT 353 L L + Q + + L+ L T Sbjct: 372 DLPPLPALSLYSPGLQQLAHLLLEADPIKRIRIGEAKRVLQCLLWGPRRELVQQPG---T 428 Query: 354 AKEAMG---HPWFAPIR 367 ++EA+ H W R Sbjct: 429 SEEALCGTLHNWIDMKR 445 >6EAS-A nrPDB Length = 308 Score = 48.6 bits (114), Expect = 5e-06, Method: Composition-based stats. Identities = 40/253 (15%), Positives = 80/253 (31%), Gaps = 45/253 (17%) Query: 112 EDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILY-----PK 166 ++ R I + H N ++L ++ T +VFEY N K Sbjct: 82 KENESQYRKKITNLSKVSHKNFMNLLGYCEEEHPFTRVMVFEYAPNGTLFEHLHVREAEK 141 Query: 167 LTDLEIRFYMFELLKALDYCHSMGI--MHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVN 224 L + + L++ H + R+ V + + ++ D EF++ Sbjct: 142 LDWMARLRISMGIAYCLEHMHQLQTPAALRNFDSTTVYLT-DDFAAKVSDL---EFWNDA 197 Query: 225 MEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKI 284 +N + P++ R Y G +L ++ R P + V Sbjct: 198 KGHNSTTNNELAFSPDMEDIVRKY---------GMVLLEILTGRVPSSEDDGPLENWV-- 246 Query: 285 VKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLL 344 + FE + E+ P + F D + L +++ + + Sbjct: 247 -----SRYFEGGMRLEELIDPSIGF------------FPEDTARALC------EVVRSCI 283 Query: 345 RYDHQERLTAKEA 357 D ++R KE Sbjct: 284 DRDPKKRPQMKEV 296 >3BYV-A nrPDB Length = 377 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 26/172 (15%), Positives = 57/172 (33%), Gaps = 27/172 (15%) Query: 164 YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHV 223 + L ++++ L H G++H ++P ++++D + + L + E Sbjct: 200 HKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGG-VFLTGF---EHLVR 255 Query: 224 NMEYNVRVASRFFKGPELLVDYRMY----------DYSLDLWSFGTMLASMIFKREP--- 270 + V SR F+ PEL +S D W+ G ++ + P Sbjct: 256 DGARVVSSVSRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLPITK 315 Query: 271 ----------FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMD 312 F + + +++ E LL + E+ + Sbjct: 316 DAALGGSEWIFRSCKNIPQPVRALLEGFLRYPKEDRLLPLQAMETPEYEQLR 367 >4CYJ-A nrPDB Length = 438 Score = 45.1 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 26/166 (15%), Positives = 55/166 (33%), Gaps = 25/166 (15%) Query: 51 YSE---VFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYY 107 + V++ + ++ L + ++ E IL + + K + + Sbjct: 65 FGYPSWVYKAQNSRNGRHYALRRL---EGYRLTNEKAILNVMKDWKKIKNASIVTIHEVF 121 Query: 108 TNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKL 167 T ++ I Y F H L + PI P + Sbjct: 122 TTREFGDSSLIFAYDF------HPLSKTLQEHHFQPIHGNRY------------RPPPAV 163 Query: 168 TDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLI 213 + I Y+ ++ AL HS + R ++P +++ N ++RL Sbjct: 164 PENTIWGYICQIANALKTIHSNRLAARCLEPSKIILTDIN-RIRLS 208 >3DZO-A nrPDB Length = 413 Score = 44.3 bits (103), Expect = 8e-05, Method: Composition-based stats. Identities = 25/191 (13%), Positives = 60/191 (31%), Gaps = 26/191 (13%) Query: 164 YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHV 223 + L ++++ L H G++H ++P ++++D + + L G Sbjct: 205 HKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGG-VFLT--GFEHLVRD 261 Query: 224 NMEYNVRVASRFFKGP----ELLVDYRMY-----DYSLDLWSFGTMLASMIFKREP---- 270 + R F P E ++ + + ++ D W+ G + + P Sbjct: 262 GASAVSPIG-RGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLPNTDD 320 Query: 271 ---------FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHR 321 F + + +++ E LL + E+ + + Sbjct: 321 AALGGSEWIFRSCKNIPQPVRALLEGFLRYPKEDRLLPLQAMETPEYEQLRTELSAALPL 380 Query: 322 FINDGNKHLSG 332 + DG G Sbjct: 381 YQTDGEPTREG 391 >5I35-A nrPDB Length = 393 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 34/228 (14%), Positives = 66/228 (28%), Gaps = 16/228 (7%) Query: 4 RVWSEARVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGVKLDSK 63 +++ R + + + +W + +E E +V + Sbjct: 41 KIFERVRQSADFMPLKQMMKTLNNDLGPNWRDKLEYFE-ERPFAAASIGQVHLAR-MKGG 98 Query: 64 VKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLK------F 117 ++ +K+ P + I ++ L + N F + ++E L+ Sbjct: 99 REVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELALECDYQREA 158 Query: 118 IRPYIFDQPHNGHANIIHLFDI--IKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFY 175 F GH F + I D + L E V L+ Sbjct: 159 ACARKFRDLLKGHP----FFYVPEIVDELCSPHVLTTELVSGFPL-DQAEGLSQEIRNEI 213 Query: 176 MFELL-KALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYH 222 + +L L M D N D + K+ L+D+G Y Sbjct: 214 CYNILVLCLRELFEFHFMQTDPNWSNFFYDPQQHKVALLDFGATREYD 261 >4OAU-C nrPDB Length = 699 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 2/48 (4%) Query: 169 DLEIRFYMFELLKALDYCH-SMGIMHRDVKPHNVMIDHKNKKLRLIDW 215 D R + + KA+ H S G H+D++P N++ID K K L D+ Sbjct: 438 DEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK-KAAHLADF 484 Score = 34.3 bits (77), Expect = 0.082, Method: Composition-based stats. Identities = 19/90 (21%), Positives = 29/90 (32%) Query: 281 LVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLI 340 K +K G K L+ L + N+ LS ++E DLI Sbjct: 484 FDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLI 543 Query: 341 DNLLRYDHQERLTAKEAMGHPWFAPIREQI 370 L R + +GHP+F + Sbjct: 544 HRLFHPGEHVRDCLSDLLGHPFFWTWESRY 573 >3ENH-A nrPDB Length = 540 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 18/91 (19%), Positives = 41/91 (45%), Gaps = 8/91 (8%) Query: 139 IIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKP 198 I D ++ Y++ + + +L+I + + E+ + H ++H D+ Sbjct: 405 YIFDVDLDNKRIMMSYINGKLAKDVIE--DNLDIAYKIGEI---VGKLHKNDVIHNDLTT 459 Query: 199 HNVMIDHKNKKLRLIDWGLAEFYHVNMEYNV 229 N + D K L +ID+GL + +++ + V Sbjct: 460 SNFIFD---KDLYIIDFGLGKISNLDEDKAV 487 >5GZA-A nrPDB Length = 290 Score = 41.3 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 36/215 (16%), Positives = 63/215 (29%), Gaps = 34/215 (15%) Query: 71 LKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGH 130 LK + + R +K++ + +KV + QK + + Sbjct: 18 LKCPEIRSGVRRVKLIGQGAVKKVYLSEWQGQKVALSVLSSDQYADDFLHGLSMLRALQS 77 Query: 131 ANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRF---YMFELLKALDYCH 187 ++++ L + ++ V EY L L R+ + L A+DY Sbjct: 78 SHVVTLVGVCEEDA----VFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLAIDYVA 133 Query: 188 SMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYH------------VNMEYNVRVA--- 232 + +H VM D + L + LA V+ Sbjct: 134 FLAYLHSSPAGIRVMCDSNDLHKTLSQFLLASDMRLLANDLDALPEVEKGGLGVKCGHHE 193 Query: 233 -SRFFKGPELLVDYR-----------MYDYSLDLW 255 + F PE L Y YD D+W Sbjct: 194 LTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >2W1Z-A nrPDB Length = 368 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 49/375 (13%), Positives = 108/375 (28%), Gaps = 90/375 (24%) Query: 10 RVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGR--------------GKYSEVF 55 RV +N N + W E + + +E+++G G Y Sbjct: 27 RVLSNANHLVSTALWRNEQS----------FRVESELGERPRTLVRGPVLRDDGSY-ICL 75 Query: 56 QGVKLDSKVKI--------------VIKMLKP-VKKKKIKREIKILTDLSNE-----KVP 95 + ++ + IK L V + ++ R IK + Sbjct: 76 EATDQETGEPLEVHVPYFTERPPSNAIKQLSEQVLRLRLLRGIKNQRQAKAYLRFIFPID 135 Query: 96 PTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYV 155 P ++ E + + + + +I+ D++ S +LV Sbjct: 136 LVKDPKKRKMIRVRLDERDMWVLSRFFLYPRMQSNLHILG--DVLLSHSSTHKSLV---- 189 Query: 156 DNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDW 215 + +L +L++ G++H D + N+++D + + L Sbjct: 190 -------HHARLQ------LTLQLIRLAASLQHYGLVHADFQVRNILLDQRGG-VFLT-- 233 Query: 216 GLAEFYHVNMEYNVRVASRFFKGP----ELLVDYRMY-----DYSLDLWSFGTMLASMIF 266 G + R F P E ++ YR + + D W+ G + + Sbjct: 234 GFEHLVRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWC 292 Query: 267 KREP-------------FFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQ 313 P + + + +++ E LL + E+ + Sbjct: 293 ADLPNTEDAELGGIEWIYRRCKNIPQPVRALLEGFLRYSKEDRLLPLQAMETSEYEQLRT 352 Query: 314 YIRKPWHRFINDGNK 328 + + DG Sbjct: 353 ELSAVLPLYQTDGEP 367 >5GZ9-A nrPDB Length = 305 Score = 38.9 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 28/216 (12%), Positives = 66/216 (30%), Gaps = 38/216 (17%) Query: 74 VKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQ---PHNGH 130 + ++++ E++ L + V L K+ + L+ ++ Sbjct: 27 LSCEELRTEVRQLKRVGEGAVKRVFLSEWKEHKVALSRLTRLEMKEDFLHGLQMLKSLQS 86 Query: 131 ANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTD---LEIRFYMFELLKALDYCH 187 +++ L ++ + ++ EY L L ++ + L A++Y Sbjct: 87 EHVVTLVGYCEEDGT----ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVS 142 Query: 188 SMGIMH------------RDV-KPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASR 234 + +H D+ K + + N + D + ++ R Sbjct: 143 IINYLHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHR 202 Query: 235 F----FKGPELLVDYR-----------MYDYSLDLW 255 F PE L Y Y+ +D+W Sbjct: 203 ELHGDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW 238 >1TQM-A nrPDB Length = 282 Score = 38.6 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 30/174 (17%), Positives = 64/174 (36%), Gaps = 31/174 (17%) Query: 42 IENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPF 101 I +G GK S VF + +K K +++K D + + Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECV-VKFHKVGHTS--FKKVKEKRDYGDLHFSVLAIRS 150 Query: 102 QKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFR 161 ++++ QK L + Y ++ A++ E +D + Sbjct: 151 ARNEFRALQKLQGLAVPKVYAWEGN----------------------AVLMELIDAKELY 188 Query: 162 ILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDW 215 + + D + + E+ K + H GI+H D+ +NV++ + + +ID+ Sbjct: 189 RVRVENPDEVLDMILEEVAK---FYH-RGIVHGDLSQYNVLVSEEG--IWIIDF 236 >6FAI-l nrPDB Length = 425 Score = 35.5 bits (80), Expect = 0.044, Method: Composition-based stats. Identities = 35/226 (15%), Positives = 76/226 (33%), Gaps = 36/226 (15%) Query: 4 RVWSEARVYTNINKQRTEEYWDY-------ENTVIDWSTNTKD-YEIENKVGRGKYSEVF 55 R S+ + I+K R +Y Y + + N Y + N +G GK S+++ Sbjct: 51 RAISDLAKLSLISKMRNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESDIY 110 Query: 56 QGVKLDSKVKIV-IKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDV 114 + + +++ I L ++ L + ++ Y Sbjct: 111 KVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMS--- 167 Query: 115 LKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRF 174 + + + + +P + +I+ V E ++ R L I Sbjct: 168 MLYSKGFKVPEPFDNSRHIV----------------VMELIEGYPMRRLRK---HKNIPK 208 Query: 175 YMFELLKALDYCHSMGIMHRDVKPHNVMI-----DHKNKKLRLIDW 215 +L+ + + G++H D N+MI D + +ID+ Sbjct: 209 LYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >4WWA-A nrPDB Length = 261 Score = 35.1 bits (79), Expect = 0.052, Method: Composition-based stats. Identities = 13/56 (23%), Positives = 22/56 (39%), Gaps = 6/56 (10%) Query: 164 YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK--LRLIDWGL 217 Y L +R ++ L H H D+ N+++ + LID+GL Sbjct: 134 YSDLVATTLRKVGRQI--GL--LHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >4BVU-A nrPDB Length = 211 Score = 34.3 bits (77), Expect = 0.091, Method: Composition-based stats. Identities = 13/73 (17%), Positives = 26/73 (35%), Gaps = 3/73 (4%) Query: 143 PISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM 202 L V + I +L+ L+ + I+H D+ N++ Sbjct: 104 QYGGDVYLRMLRVPGTPLSDIDTADIPDNIESLYLQLICKLN---ELSIIHYDLNTGNML 160 Query: 203 IDHKNKKLRLIDW 215 D +++ L ID+ Sbjct: 161 YDKESESLFPIDF 173 >4CZY-B nrPDB Length = 429 Score = 33.9 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 23/159 (14%), Positives = 51/159 (32%), Gaps = 22/159 (13%) Query: 55 FQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDV 114 ++ + L+ ++ ++ E IL K + +T + Sbjct: 61 YKAQNNKNGRHFA---LRRIEGYRLTNEKAILNVTKEWKKIINANIVTVHEAFTTEFFGD 117 Query: 115 LKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALVFEYVDNVDFRILYPKLTDLEIRF 174 I Y F H L+D P + L K+ + + Sbjct: 118 SSLIFVYDF------HPLSETLYDHHFPPNNSHNRL-----------RNTNKIPENLLWS 160 Query: 175 YMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLI 213 Y+ ++ AL H+ + R ++ ++ +N ++RL Sbjct: 161 YVCQIANALLAIHNAKLAARCLELSKII--WENNRIRLA 197 >4BWP-A nrPDB Length = 448 Score = 33.2 bits (74), Expect = 0.22, Method: Composition-based stats. Identities = 22/164 (13%), Positives = 50/164 (30%), Gaps = 23/164 (14%) Query: 55 FQGVKLDSKVKIVIKMLK--PVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKE 112 ++ + K ++ + ++ K +++ L + V F + + Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTKAFG----D 122 Query: 113 DVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV---------FEYVDNVDFRIL 163 + L + Y H L P +T F + N+ Sbjct: 123 NSLVLVYDY--------HPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSN 174 Query: 164 YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN 207 P L + I + +L L H G+ + + P +++ K Sbjct: 175 GPLLPEATIWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKR 218 >6EF6-A nrPDB Length = 354 Score = 31.2 bits (69), Expect = 0.77, Method: Composition-based stats. Identities = 11/50 (22%), Positives = 23/50 (46%), Gaps = 13/50 (26%) Query: 179 LLKALDYCHSM-----------GIMHRDVKPHNVMIDHKNKK--LRLIDW 215 L +A D H G++H D++ N+++D + + +ID+ Sbjct: 204 LTRAQDLLHRKLEEYGSGPDRYGLIHADLRLANLLVDSSTPQRTITVIDF 253 >4GYG-A nrPDB Length = 397 Score = 31.2 bits (69), Expect = 0.80, Method: Composition-based stats. Identities = 28/186 (15%), Positives = 59/186 (31%), Gaps = 23/186 (12%) Query: 22 EYWDYENTVIDWSTNTKD-YEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIK 80 Y + + KD Y + +++G GK S++ K K+ Sbjct: 78 TYGGLDYLALHTHAARKDVYSVGSRIGVGKESDIMIVADEKGKQKV-------------- 123 Query: 81 REIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDII 140 +I L +S V + + L I+ + F + F + Sbjct: 124 LKIHRLGRISFRTVKANRDYLRNRSTGSWMYLSRLAAIKEFAFMKALYEEG-----FPVP 178 Query: 141 KDPISKTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHN 200 + +V VD + R + + + +L+ + G++H D N Sbjct: 179 EPIAQSRHTIVMSLVDALPMRQVS---SVPDPASLYADLIALILRLAKHGLIHGDFNEFN 235 Query: 201 VMIDHK 206 ++I + Sbjct: 236 ILIREE 241 >2Y0O-A nrPDB Length = 175 Score = 30.9 bits (68), Expect = 0.86, Method: Composition-based stats. Identities = 12/47 (25%), Positives = 26/47 (55%) Query: 197 KPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLV 243 K V+ D + +++L+D+GL + V ++ V V + + EL++ Sbjct: 14 KAGIVLTDEEVDQIQLMDYGLGKERKVGLQLFVYVNTDRYCSKELVL 60 >4H05-A nrPDB Length = 273 Score = 30.9 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 10/27 (37%), Positives = 17/27 (62%), Gaps = 1/27 (3%) Query: 191 IMHRDVKPHNVMIDHKNKKLR-LIDWG 216 + H D+ P NV++D + ++ LID G Sbjct: 186 VCHGDLCPDNVLLDPRTCEVTGLIDVG 212 >2QTV-A nrPDB Length = 772 Score = 30.5 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 12/85 (14%), Positives = 30/85 (35%), Gaps = 3/85 (3%) Query: 261 LASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWH 320 L M+ ++P G + L + + ++ L E + ++ W Sbjct: 197 LTEMLTGQKPTGPGGA-ASHLPNAMNKVTPFSLNRFFLPLEQVEFKLNQLLENLSPDQWS 255 Query: 321 RFINDGNKHLSGNDEIIDLIDNLLR 345 + G++ L +++ LL+ Sbjct: 256 --VPAGHRPLRATGSALNIASLLLQ 278 >4FZ2-A nrPDB Length = 395 Score = 29.7 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 20/113 (17%), Positives = 40/113 (35%), Gaps = 12/113 (10%) Query: 88 DLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKT 147 +S ++ + F R I + +I+ L+D+ KD +K Sbjct: 161 KVSEHGNLNKLDIYETLFLIDMGVISIKNFTRAQIVNIASARRTDIMKLYDVYKDWRTKG 220 Query: 148 PALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMH---RDVK 197 + + +FRI +P + + ++ HS ++H RD K Sbjct: 221 YVVKTGFKFGTNFRIYFPG---------AKPIKENNEWIHSKHVLHVFPRDSK 264 >5DXT-A nrPDB Length = 962 Score = 29.3 bits (64), Expect = 2.7, Method: Composition-based stats. Identities = 19/111 (17%), Positives = 41/111 (36%), Gaps = 11/111 (9%) Query: 86 LTDLSNEKVPPTTLPFQKDQYYTNQKE--DVLKFIRPYIFDQPHNGHANIIHLFDIIKDP 143 L +S +KD ++++ + + + + N + ++ ++KD Sbjct: 425 LKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDW 484 Query: 144 ISKTPALVFEYVD---------NVDFRILYPKLTDLEIRFYMFELLKALDY 185 P E +D R L LTD ++ Y+ +L++ L Y Sbjct: 485 PPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKY 535 >4AJW-A nrPDB Length = 934 Score = 29.3 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 20/122 (16%), Positives = 42/122 (34%), Gaps = 11/122 (9%) Query: 75 KKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKF---IRPYIFDQPHNGHA 131 ++ +I E L ++ + +KD + + E F + + N H Sbjct: 390 ERGRITEEELQLREILERRGSGELYEHEKDLVWKMRHEVQEHFPEALARLLLVTKWNKHE 449 Query: 132 NIIHLFDIIKDPISKTPALVFEYVD--------NVDFRILYPKLTDLEIRFYMFELLKAL 183 ++ + ++ E +D KLTD E+ Y+ +L++ L Sbjct: 450 DVAQMLYLLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQLVQVL 509 Query: 184 DY 185 Y Sbjct: 510 KY 511 >1YGP-A nrPDB Length = 879 Score = 28.5 bits (62), Expect = 4.2, Method: Composition-based stats. Identities = 23/117 (19%), Positives = 45/117 (38%), Gaps = 12/117 (10%) Query: 86 LTDLSNEKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPIS 145 L L +E + T + D Q E ++ + ++ N I L D+IK Sbjct: 529 LAKLISETLNDPTEEYLLDMAKLTQLEKYVE-DKEFLKKWNQVKLNNKIRLVDLIKKEND 587 Query: 146 KTPALVFEYVDNVDFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVM 202 + EY+D+ F + ++ + Y + L GI++R + N++ Sbjct: 588 GVDIINREYLDDTLFDMQVKRIHE-----YKRQQLNVF------GIIYRYLAMKNML 633 >1Z82-A nrPDB Length = 335 Score = 27.8 bits (60), Expect = 7.6, Method: Composition-based stats. Identities = 17/137 (12%), Positives = 45/137 (32%), Gaps = 16/137 (11%) Query: 45 KVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKD 104 +G G + VF + ++ ++++ ++EI L ++S+ Sbjct: 19 VLGAGSWGTVFAQMLHENGEEVIL--------WARRKEIVDLINVSHTSPYVEESKITVR 70 Query: 105 QYYTNQKEDVLKFIRPYIFDQPHNGH--------ANIIHLFDIIKDPISKTPALVFEYVD 156 ++ + I Q H + +++L I+ K + + E + Sbjct: 71 ATNDLEEIKKEDILVIAIPVQYIREHLLRLPVKPSMVLNLSKGIEIKTGKRVSEIVEEIL 130 Query: 157 NVDFRILYPKLTDLEIR 173 + +L E+ Sbjct: 131 GCPYAVLSGPSHAEEVA 147 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.129 0.385 Lambda K H 0.267 0.0396 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,049,995 Number of Sequences: 36641 Number of extensions: 640799 Number of successful extensions: 6014 Number of sequences better than 10.0: 505 Number of HSP's better than 10.0 without gapping: 817 Number of HSP's successfully gapped in prelim test: 146 Number of HSP's that attempted gapping in prelim test: 2009 Number of HSP's gapped (non-prelim): 1697 length of query: 372 length of database: 10,336,785 effective HSP length: 99 effective length of query: 273 effective length of database: 6,709,326 effective search space: 1831645998 effective search space used: 1831645998 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 60 (27.8 bits)