BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P15651 (412 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1JQI-A nrPDB 801 0.0 2VIG-A nrPDB 731 0.0 5OL2-C nrPDB 410 e-115 4L1F-A nrPDB 384 e-107 4N5F-A nrPDB 360 e-100 5LNX-A nrPDB 360 e-100 6FAH-C nrPDB 348 2e-96 4U83-A nrPDB 346 9e-96 4M9A-A nrPDB 338 2e-93 1BUC-A nrPDB 332 1e-91 1UKW-A nrPDB 327 6e-90 3PFD-A nrPDB 314 4e-86 2DVL-A nrPDB 301 3e-82 4O5M-A nrPDB 297 7e-81 2JIF-A nrPDB 296 8e-81 4KTO-A nrPDB 290 8e-79 2CX9-A nrPDB 288 3e-78 2A1T-A nrPDB 282 2e-76 3MDE-A nrPDB 280 1e-75 3NF4-A nrPDB 273 1e-73 2Z1Q-A nrPDB 266 1e-71 1RX0-A nrPDB 265 3e-71 1IVH-A nrPDB 265 3e-71 3MPI-A nrPDB 257 7e-69 3OWA-A nrPDB 251 6e-67 4IV6-A nrPDB 238 3e-63 2PG0-A nrPDB 236 1e-62 6ES9-A nrPDB 230 7e-61 4IRN-A nrPDB 227 9e-60 5IDU-A nrPDB 223 9e-59 5JSC-A nrPDB 219 2e-57 3B96-A nrPDB 214 4e-56 2EBA-A nrPDB 209 1e-54 3SWO-A nrPDB 207 5e-54 3R7K-A nrPDB 205 3e-53 3SF6-A nrPDB 204 4e-53 6CY8-B nrPDB 204 7e-53 3P4T-A nrPDB 203 9e-53 3GNC-A nrPDB 201 4e-52 5AHS-A nrPDB 201 7e-52 1SIR-A nrPDB 177 1e-44 2IX5-A nrPDB 168 4e-42 4W9U-A nrPDB 162 2e-40 4HR3-A nrPDB 145 3e-35 5ZW7-A nrPDB 144 8e-35 4RM7-A nrPDB 134 7e-32 2WBI-A nrPDB 129 2e-30 1R2J-A nrPDB 124 1e-28 5EZ3-A nrPDB 103 1e-22 4X28-A nrPDB 102 3e-22 3M9V-A nrPDB 101 7e-22 3U33-A nrPDB 96 2e-20 3MKH-A nrPDB 96 4e-20 4X28-D nrPDB 92 4e-19 4ZYJ-A nrPDB 92 5e-19 3MXL-A nrPDB 88 6e-18 2C12-A nrPDB 85 6e-17 5GJ7-A nrPDB 82 4e-16 5Y9D-A nrPDB 74 1e-13 5YS9-A nrPDB 70 1e-12 4Y9J-A nrPDB 70 2e-12 4JEK-A nrPDB 67 2e-11 5XDD-A nrPDB 65 6e-11 4XVX-A nrPDB 59 4e-09 1W07-A nrPDB 56 2e-08 1IS2-A nrPDB 55 5e-08 2FON-A nrPDB 54 1e-07 5K3G-A nrPDB 53 3e-07 5K3J-A nrPDB 52 4e-07 2RFQ-A nrPDB 45 8e-05 3AFF-A nrPDB 39 0.004 5LVW-A nrPDB 33 0.23 3CF4-A nrPDB 32 0.38 2OR0-A nrPDB 30 2.4 2PH3-A nrPDB 30 2.6 4AF0-B nrPDB 30 2.9 >1JQI-A nrPDB Length = 388 Score = 801 bits (2069), Expect = 0.0, Method: Compositional matrix adjust. Identities = 387/388 (99%), Positives = 388/388 (100%) Query: 25 LHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDV 84 LH+VYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDV Sbjct: 1 LHSVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDV 60 Query: 85 PEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFT 144 PEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFT Sbjct: 61 PEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFT 120 Query: 145 NGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRS 204 NGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRS Sbjct: 121 NGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRS 180 Query: 205 RQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIA 264 RQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIA Sbjct: 181 RQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIA 240 Query: 265 MQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESA 324 MQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESA Sbjct: 241 MQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESA 300 Query: 325 RLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRD 384 RLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRD Sbjct: 301 RLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRD 360 Query: 385 ARITEIYEGTSEIQRLVIAGHLLRSYRS 412 ARITEIYEGTSEIQRLVIAGHLLRSYRS Sbjct: 361 ARITEIYEGTSEIQRLVIAGHLLRSYRS 388 >2VIG-A nrPDB Length = 391 Score = 731 bits (1886), Expect = 0.0, Method: Compositional matrix adjust. Identities = 351/383 (91%), Positives = 366/383 (95%) Query: 30 QSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELS 89 QSVELPETHQML QTCRDFAEKEL PIAAQ+DKEHLFP +QVKKMG LGLLAMDVPEEL Sbjct: 2 QSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELG 61 Query: 90 GAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKI 149 GAGLDYLAY+IA+EEISRGCASTGVIMSVNNSLYLGPILKFGS +QKQ W+TPFT+GDKI Sbjct: 62 GAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLGPILKFGSKEQKQAWVTPFTSGDKI 121 Query: 150 GCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKG 209 GCFALSEPGNGSDAGAASTTAR EGDSWVLNGTKAWITN+WEASA VVFASTDR+ QNK Sbjct: 122 GCFALSEPGNGSDAGAASTTARAEGDSWVLNGTKAWITNAWEASAAVVFASTDRALQNKS 181 Query: 210 ISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLD 269 ISAFLVPMPTPGLTLGKKEDKLGIR SSTANLIFEDCRIPK+++LGEPGMGFKIAMQTLD Sbjct: 182 ISAFLVPMPTPGLTLGKKEDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLD 241 Query: 270 MGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTW 329 MGRIGIASQALGIAQ +LDCAV YAENR AFGAPLTKLQ IQFKLADMALALESARLLTW Sbjct: 242 MGRIGIASQALGIAQTALDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTW 301 Query: 330 RAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITE 389 RAAMLKDNKKPF KE+AMAKLAASEAATAISHQAIQILGGMGYVTEMPAER+YRDARITE Sbjct: 302 RAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITE 361 Query: 390 IYEGTSEIQRLVIAGHLLRSYRS 412 IYEGTSEIQRLVIAGHLLRSYRS Sbjct: 362 IYEGTSEIQRLVIAGHLLRSYRS 384 >5OL2-C nrPDB Length = 378 Score = 410 bits (1053), Expect = e-115, Method: Compositional matrix adjust. Identities = 195/371 (52%), Positives = 268/371 (72%) Query: 38 HQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLA 97 +QML++ FAE E+ P+A +LD+E FP V+KM + G++ + P+E G G D + Sbjct: 8 YQMLKELYVSFAENEVKPLATELDEEERFPYETVEKMAKAGMMGIPYPKEYGGEGGDTVG 67 Query: 98 YSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEP 157 Y +A+EE+SR C +TGVI+S + SL PI ++G+ +QKQ+++ P +G+K+G F L+EP Sbjct: 68 YIMAVEELSRVCGTTGVILSAHTSLGSWPIYQYGNEEQKQKFLRPLASGEKLGAFGLTEP 127 Query: 158 GNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPM 217 G+DA TTA +GD ++LNG+K +ITN+ VV A TD+S+ NKGISAF+V Sbjct: 128 NAGTDASGQQTTAVLDGDEYILNGSKIFITNAIAGDIYVVMAMTDKSKGNKGISAFIVEK 187 Query: 218 PTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIAS 277 TPG + G KE K+GIR S+T+ LIFEDCRIPKENLLG+ G GFKIAM TLD GRIGIA+ Sbjct: 188 GTPGFSFGVKEKKMGIRGSATSELIFEDCRIPKENLLGKEGQGFKIAMSTLDGGRIGIAA 247 Query: 278 QALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDN 337 QALG+AQ +LD VKY + R FG PL+K QN QF+LADM + +++AR L ++AA+ KD Sbjct: 248 QALGLAQGALDETVKYVKERVQFGRPLSKFQNTQFQLADMEVKVQAARHLVYQAAINKDL 307 Query: 338 KKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEI 397 KP+ E+AMAKL A+E A ++ +A+Q+ GG GY + P ER RDA+ITEIYEGTSE+ Sbjct: 308 GKPYGVEAAMAKLFAAETAMEVTTKAVQLHGGYGYTRDYPVERMMRDAKITEIYEGTSEV 367 Query: 398 QRLVIAGHLLR 408 QR+VI+G LL+ Sbjct: 368 QRMVISGKLLK 378 >4L1F-A nrPDB Length = 383 Score = 384 bits (985), Expect = e-107, Method: Compositional matrix adjust. Identities = 186/378 (49%), Positives = 254/378 (67%) Query: 34 LPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGL 93 L E QM++ +FAEK L P + DK H++ + KMGE G + PEE G GL Sbjct: 5 LTEDQQMIKDMAAEFAEKFLAPTVEERDKAHIWDRKLIDKMGEAGFCGICFPEEYGGMGL 64 Query: 94 DYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFA 153 D L+Y +A+EE+S+ TG+ +S N SL PI FG+ +QKQ+++ P G +G F Sbjct: 65 DVLSYILAVEELSKVDDGTGITLSANVSLCATPIYMFGTEEQKQKYLAPIAEGTHVGAFG 124 Query: 154 LSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAF 213 L+EP G+DA A TTA +GD ++LNG+K +ITN EA VVFA TD+S+ GISAF Sbjct: 125 LTEPSAGTDASAQQTTAVLKGDKYILNGSKIFITNGKEADTYVVFAMTDKSQGVHGISAF 184 Query: 214 LVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRI 273 ++ PG GK EDK+G S TA LIFEDC +PKENLLG+ G GFKIAM+TLD GRI Sbjct: 185 ILEKGMPGFRFGKIEDKMGGHTSITAELIFEDCEVPKENLLGKEGEGFKIAMETLDGGRI 244 Query: 274 GIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAM 333 G+A+QALGIA+ +L AVKY++ R FG ++K Q +QF +ADMA +E+AR L + AAM Sbjct: 245 GVAAQALGIAEGALAAAVKYSKEREQFGRSISKFQALQFMMADMATKIEAARYLVYHAAM 304 Query: 334 LKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEG 393 LK+ KP+++ +AMAK AS+ A ++ A+QI GG GY + PAERY R+A+IT+IYEG Sbjct: 305 LKNEGKPYSEAAAMAKCFASDVAMEVTTDAVQIFGGYGYTVDYPAERYMRNAKITQIYEG 364 Query: 394 TSEIQRLVIAGHLLRSYR 411 T+++ R+V + LLR + Sbjct: 365 TNQVMRIVTSRALLRDKK 382 >4N5F-A nrPDB Length = 385 Score = 360 bits (925), Expect = e-100, Method: Compositional matrix adjust. Identities = 187/371 (50%), Positives = 242/371 (65%) Query: 36 ETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDY 95 E +M+R R FA + L P AAQ D + P + V ++GELGLL M VP+EL G+ DY Sbjct: 15 EDQRMIRDAARAFATEMLAPNAAQWDHDAHLPDAIVAQLGELGLLGMIVPQELGGSYTDY 74 Query: 96 LAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALS 155 +AY++A+EE++ G A+ +MSV+NS+ GPIL FG+ QK +W+ G IG F L+ Sbjct: 75 VAYALAMEEVAAGDAACATMMSVHNSVGCGPILGFGTPAQKDRWLADMAAGRVIGAFCLT 134 Query: 156 EPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLV 215 EP GS+A T A WVLNG K ++TN A +VFA TD +GISAFLV Sbjct: 135 EPHAGSEANNLRTRAELRDGQWVLNGAKQFVTNGQRAGVAIVFAMTDPEAGKRGISAFLV 194 Query: 216 PMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGI 275 P TPG +GK E K+GIRAS T + FE+C IP++NLLG G G KIA+ L+ GRIGI Sbjct: 195 PTDTPGFIVGKPEKKMGIRASDTCPITFENCAIPEDNLLGNRGEGLKIALSNLEGGRIGI 254 Query: 276 ASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLK 335 A+QALGIA+A+ D A +YA R FG P+ + Q IQ KLADMA+ + +ARLL AA L+ Sbjct: 255 AAQALGIARAAFDKARRYAGERVQFGKPIAEHQAIQQKLADMAVQINAARLLVHHAAKLR 314 Query: 336 DNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTS 395 P E++ AKL ASE A + AIQI GG GY+ + ER+YRDARIT+IYEGTS Sbjct: 315 TAGLPCLSEASQAKLFASEMAERVCSDAIQIHGGYGYLVDYEVERHYRDARITQIYEGTS 374 Query: 396 EIQRLVIAGHL 406 E+QR+VIA L Sbjct: 375 EVQRMVIARQL 385 >5LNX-A nrPDB Length = 379 Score = 360 bits (923), Expect = e-100, Method: Compositional matrix adjust. Identities = 182/368 (49%), Positives = 251/368 (68%) Query: 40 MLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYS 99 M+R+ RDFA KE+ P A ++K FP +KKMG+ GL+ + VPE+ GAG D ++Y Sbjct: 9 MMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMGKHGLMGIPVPEQYGGAGADVVSYI 68 Query: 100 IALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGN 159 +A+ EISR A+ GVI+SV+ S+ PIL FG+ +QK ++I +GD +G FAL+EP + Sbjct: 69 LAIHEISRISAAVGVILSVHTSVGTNPILYFGNEEQKMKYIPNLASGDHLGAFALTEPHS 128 Query: 160 GSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPT 219 GSDAG+ TTA ++ ++LNG+K +ITN A + FA T + GISAF+V T Sbjct: 129 GSDAGSLRTTAIKKNGKYLLNGSKIFITNGGAADIYITFALTAPDQGRHGISAFIVEKNT 188 Query: 220 PGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQA 279 PG T+GKKE KLG+ S+T LIF++ +P+ NLLG+ G GF IAM L++GRIGIA+QA Sbjct: 189 PGFTVGKKERKLGLYGSNTTELIFDNAEVPEANLLGKEGDGFHIAMANLNVGRIGIAAQA 248 Query: 280 LGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKK 339 LGIA+A+L+ AV YA+ R FG P+ Q I FKLADMA E+AR L + AA L + Sbjct: 249 LGIAEAALEHAVDYAKQRVQFGRPIAANQGISFKLADMATRAEAARHLVYHAADLHNRGL 308 Query: 340 PFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQR 399 KE++MAK AS+AA + A+QI GG GY+ + P ER RDA++T+IYEGT+EIQR Sbjct: 309 NCGKEASMAKQFASDAAVKAALDAVQIYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQR 368 Query: 400 LVIAGHLL 407 L+I+ +LL Sbjct: 369 LIISKYLL 376 >6FAH-C nrPDB Length = 379 Score = 348 bits (894), Expect = 2e-96, Method: Compositional matrix adjust. Identities = 171/376 (45%), Positives = 249/376 (66%), Gaps = 1/376 (0%) Query: 34 LPETHQMLRQTCRDFAEKELVP-IAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAG 92 E ++M+R+ RDFAEKEL I ++++ FP + KM + G + +P+ L G+G Sbjct: 3 FSEQNKMIRKLARDFAEKELTTEILDEVEESGEFPQEILDKMAKFGFFGIKIPKSLGGSG 62 Query: 93 LDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCF 152 D+++Y I +EE +R V +S NSL GP+L G+ +Q ++++ P G K F Sbjct: 63 GDHMSYVICMEEFARVSGVASVYLSSPNSLAGGPLLLSGTEEQIEKYLKPIITGKKKLAF 122 Query: 153 ALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISA 212 AL+EPG GSDAG STTA + GD ++LNG K +IT + V++A TD S+ +GISA Sbjct: 123 ALTEPGAGSDAGGMSTTAVDMGDYYLLNGRKTFITMAPLCDDAVIYAKTDMSKGTRGISA 182 Query: 213 FLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGR 272 F+V + + G+++GK E K+G+ +T+++I ED ++PKEN LGE GF AM+TLD+GR Sbjct: 183 FIVDLKSEGVSMGKNEHKMGLIGCATSDIIMEDVKVPKENRLGEVNKGFSNAMKTLDVGR 242 Query: 273 IGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAA 332 +G+ASQ++G+AQ +LD A+KYA+ R FG + Q I F +ADMA LE+A+LL + AA Sbjct: 243 LGVASQSIGVAQGALDEAIKYAKERKQFGKRIADFQAIAFMIADMATKLEAAKLLVYNAA 302 Query: 333 MLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYE 392 L DNKK TKE++MAK ASE I +A+QI GG GY+ E ER YRD R+ IYE Sbjct: 303 SLMDNKKNATKEASMAKFYASEICNEICAKAVQIHGGYGYIKEYKVERMYRDCRVFTIYE 362 Query: 393 GTSEIQRLVIAGHLLR 408 GTS++Q++VI+G LL+ Sbjct: 363 GTSQVQQMVISGMLLK 378 >4U83-A nrPDB Length = 382 Score = 346 bits (888), Expect = 9e-96, Method: Compositional matrix adjust. Identities = 175/370 (47%), Positives = 246/370 (66%) Query: 34 LPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGL 93 L +T + +R+ RDFA++ L P AA D+EH FP +++ +MG LG L M PEE G+ L Sbjct: 10 LTDTQEQIREAARDFAQERLAPGAAARDREHAFPRAELTEMGALGFLGMLAPEEWGGSDL 69 Query: 94 DYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFA 153 D +AY++ALEEI+ G + I+SV++S+ PIL+FG+ QK++++ G+ IG FA Sbjct: 70 DMVAYALALEEIAAGDGACSTIVSVHSSVGCMPILRFGTEDQKRRFLPKMACGEWIGGFA 129 Query: 154 LSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAF 213 L+EP GSDA A T AR +GD +V++G+K +IT+ + +VFA TD + KGISAF Sbjct: 130 LTEPQAGSDASALKTRARLDGDHYVIDGSKQFITSGKNGNVVIVFAVTDPAAGKKGISAF 189 Query: 214 LVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRI 273 +VP TPG + E KLG +S T L F + R+P EN LG G G+KIA+ L+ GRI Sbjct: 190 IVPTDTPGYEVMSVEHKLGQHSSDTCALGFTNMRVPVENRLGAEGEGYKIALANLEGGRI 249 Query: 274 GIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAM 333 GIA+QA+G+A+A+ + A YA R FG P+ + Q + F+LADMA +E+AR + AA Sbjct: 250 GIAAQAVGMARAAFEAARDYARERITFGKPIIEHQAVAFRLADMATRIETARQMVLHAAA 309 Query: 334 LKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEG 393 L++ KP E++MAKL ASE A + AIQI GG GY+ + P ER YRD R+ +IYEG Sbjct: 310 LREAGKPCLTEASMAKLVASEMAEQVCSAAIQIHGGYGYLADYPVERIYRDVRVCQIYEG 369 Query: 394 TSEIQRLVIA 403 TS++QRLVIA Sbjct: 370 TSDVQRLVIA 379 >4M9A-A nrPDB Length = 385 Score = 338 bits (868), Expect = 2e-93, Method: Compositional matrix adjust. Identities = 179/371 (48%), Positives = 243/371 (65%) Query: 36 ETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDY 95 E +M+ R F + L P AAQ D+E P V +MGELG L M VP + G+ DY Sbjct: 15 EDQRMILDAARAFCAEVLAPNAAQWDRESHLPDEVVAQMGELGFLGMIVPADWGGSYTDY 74 Query: 96 LAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALS 155 +AY++ALEEI+ GCAS ++SV+NS+ GP+L +G+++QK++W+ +G +G F+L+ Sbjct: 75 VAYALALEEIAAGCASCATLVSVHNSVGCGPVLNYGTTEQKERWLRDLASGKTVGAFSLT 134 Query: 156 EPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLV 215 EP GS+A T A W+LNG+K ++TN A +VFA TD +G+SAF+V Sbjct: 135 EPHAGSEAHNLRTRAELRDGKWILNGSKQFVTNGARAGLAIVFAMTDPDEGKRGLSAFVV 194 Query: 216 PMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGI 275 P TPG +GK E K+GIRAS T + E+C IP+ENLLG+ G G KIA+ L+ GRIGI Sbjct: 195 PTDTPGFIVGKPEKKMGIRASDTCPITLENCAIPQENLLGKRGEGLKIALSNLEGGRIGI 254 Query: 276 ASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLK 335 A+QA GIA+A+ D A +YA R FG P+ + Q I KLA+MA + +ARLLT AA L+ Sbjct: 255 AAQATGIARAAFDRARRYARERVQFGKPIAEHQAIAEKLANMATQINAARLLTHHAARLR 314 Query: 336 DNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTS 395 P E++ AKL ASE A A+ AIQI GG G++ + ER+YRDARIT+IYEGTS Sbjct: 315 TAGLPCLSEASQAKLFASEMAEAVCSDAIQIHGGYGFLVDYEVERHYRDARITQIYEGTS 374 Query: 396 EIQRLVIAGHL 406 E+QR+VIA L Sbjct: 375 EVQRMVIARQL 385 >1BUC-A nrPDB Length = 383 Score = 332 bits (852), Expect = 1e-91, Method: Compositional matrix adjust. Identities = 170/379 (44%), Positives = 244/379 (64%), Gaps = 4/379 (1%) Query: 34 LPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGL 93 L + Q + DF EK+L P + D + ++ + ++ LG+ E+ G+G Sbjct: 5 LTDIQQDFLKLAHDFGEKKLAPTVTERDHKGIYDKELIDELLSLGITGAYFEEKYGGSGD 64 Query: 94 D---YLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIG 150 D L+Y +A+EE+++ A + +S SL PI +FG+ QK++++ P G K+G Sbjct: 65 DGGDVLSYILAVEELAKYDAGVAITLSATVSLCANPIWQFGTEAQKEKFLVPLVEGTKLG 124 Query: 151 CFALSEPGNGSDAGAASTTAREEGD-SWVLNGTKAWITNSWEASATVVFASTDRSRQNKG 209 F L+EP G+DA T A + D ++ LNG+K +ITN A +VFA TD+S+ N G Sbjct: 125 AFGLTEPNAGTDASGQQTIATKNDDGTYTLNGSKIFITNGGAADIYIVFAMTDKSKGNHG 184 Query: 210 ISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLD 269 I+AF++ TPG T GKKEDK+GI S T L+F+D ++P EN+LGE G GFKIAM TLD Sbjct: 185 ITAFILEDGTPGFTYGKKEDKMGIHTSQTMELVFQDVKVPAENMLGEEGKGFKIAMMTLD 244 Query: 270 MGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTW 329 GRIG+A+QALGIA+A+L AV+Y++ R FG PL K Q+I FKLADM + +E+AR L + Sbjct: 245 GGRIGVAAQALGIAEAALADAVEYSKQRVQFGKPLCKFQSISFKLADMKMQIEAARNLVY 304 Query: 330 RAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITE 389 +AA K KPFT ++A+AK AS+ A ++ +A+QI GG GY E P R+ RDA+IT+ Sbjct: 305 KAACKKQEGKPFTVDAAIAKRVASDVAMRVTTEAVQIFGGYGYSEEYPVARHMRDAKITQ 364 Query: 390 IYEGTSEIQRLVIAGHLLR 408 IYEGT+E+Q +V G LLR Sbjct: 365 IYEGTNEVQLMVTGGALLR 383 >1UKW-A nrPDB Length = 379 Score = 327 bits (838), Expect = 6e-90, Method: Compositional matrix adjust. Identities = 171/374 (45%), Positives = 237/374 (63%), Gaps = 1/374 (0%) Query: 34 LPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGL 93 L E + L+ R FA++ ++P+A + D++ P ++K+ E+GLL +PEE G GL Sbjct: 5 LTEEQRQLQALARRFAKEVILPVAQEYDEKEEVPWPVIEKLHEVGLLNAIIPEEYGGMGL 64 Query: 94 DYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFA 153 L I EE++ C I + + L + P+L G+ +QK++++ P T + FA Sbjct: 65 KMLDEVIVGEELAYACMGIYTI-PMASDLGITPVLLAGTEEQKERFLRPLTEKPALAAFA 123 Query: 154 LSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAF 213 LSEPGNGSDA A T A +GD +VLNGTK WI+N EA VVFA+ + ++KG+ A Sbjct: 124 LSEPGNGSDAAALKTRAIRQGDHYVLNGTKMWISNGGEAEWVVVFATVNPELRHKGVVAL 183 Query: 214 LVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRI 273 +V TPG K K+G RAS T L+FED ++P EN LGE G GFKIAMQTL+ RI Sbjct: 184 VVERGTPGFKAIKIHGKMGQRASGTYELVFEDVKVPVENRLGEEGEGFKIAMQTLNKTRI 243 Query: 274 GIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAM 333 +A+ ++G+A+ +LD A KYA+ R AFG P+ Q IQFKL DM + +E+AR+ T+ AA Sbjct: 244 PVAAGSVGVARRALDEARKYAKEREAFGEPIANFQAIQFKLVDMLIGIETARMYTYYAAW 303 Query: 334 LKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEG 393 L D P SA+AK ASE A ++QAIQI GG GYV E P E+ RD ++ +IYEG Sbjct: 304 LADQGLPHAHASAIAKAYASEIAFEAANQAIQIHGGYGYVREFPVEKLLRDVKLNQIYEG 363 Query: 394 TSEIQRLVIAGHLL 407 T+EIQRL+IA H+L Sbjct: 364 TNEIQRLIIARHIL 377 >3PFD-A nrPDB Length = 393 Score = 314 bits (805), Expect = 4e-86, Method: Compositional matrix adjust. Identities = 165/381 (43%), Positives = 237/381 (62%), Gaps = 2/381 (0%) Query: 29 YQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEEL 88 ++ +LPE H LR+ R AEKE+ P AA++D++ FP + + G A+ VPEE Sbjct: 14 FELFQLPEEHIALREAIRALAEKEIAPYAAEVDEKARFPEEALAALNSSGFSAIHVPEEY 73 Query: 89 SGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDK 148 G G D +A I +EE++R S +I +VN +G IL+ GS + K+Q + +G+ Sbjct: 74 GGQGADSVATCIVIEEVARVDCSASLIPAVNKLGTMGLILR-GSEELKKQVLPAVASGEA 132 Query: 149 IGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNK 208 + +ALSE GSDA + T A +GD W+LNG+K WITN +++ V A TD + Sbjct: 133 MASYALSEREAGSDAASMRTRAVADGDDWILNGSKCWITNGGKSTWYTVMAVTDPDKGAN 192 Query: 209 GISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTL 268 GISAF+V G T+G KE KLGI+ S T L FE+CRIP + ++GEPG GFK A+ TL Sbjct: 193 GISAFMVHKDDEGFTVGPKERKLGIKGSPTTELYFENCRIPGDRIIGEPGTGFKTALATL 252 Query: 269 DMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLT 328 D R I +QA+GIAQ +LD A+ Y + R FG P++ Q +QF LADMA+ +E+ARL+ Sbjct: 253 DHTRPTIGAQAVGIAQGALDAAIAYTKERKQFGRPVSDNQGVQFMLADMAMKIEAARLMV 312 Query: 329 WRAAMLKD-NKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARI 387 + AA + + SA +K AS+ A ++ A+Q+ GG GY + P ER RDA+I Sbjct: 313 YSAAARAERGEGDLGFISAASKCFASDVAMEVTTDAVQLFGGYGYTQDFPVERMMRDAKI 372 Query: 388 TEIYEGTSEIQRLVIAGHLLR 408 T+IYEGT++IQR+V++ LLR Sbjct: 373 TQIYEGTNQIQRVVMSRALLR 393 >2DVL-A nrPDB Length = 372 Score = 301 bits (772), Expect = 3e-82, Method: Compositional matrix adjust. Identities = 171/375 (45%), Positives = 239/375 (63%), Gaps = 5/375 (1%) Query: 34 LPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGL 93 L + +++ R A + L P+A + D++ +P Q+K + ELGLL M PEE G GL Sbjct: 3 LTQEQRLVLDAVRRVAREVLYPLAPEYDRKAEYPWPQLKALAELGLLGMTTPEEWGGVGL 62 Query: 94 DYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFA 153 D + +++ALEE++ S VI+SV + L +L+FGS QK++++ P G+ IG F Sbjct: 63 DSVTWALALEELAAADPSVAVIVSVTSGLPQYMLLRFGSEAQKRRYLVPLARGEWIGAFC 122 Query: 154 LSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAF 213 L+EP GSDA + AR +VLNG K+WIT++ A VV A T+ KGISAF Sbjct: 123 LTEPQAGSDAKSLRAEARRVKGGFVLNGVKSWITSAGHAHLYVVMARTE-----KGISAF 177 Query: 214 LVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRI 273 LV TPGL+ G+ E+K+G+ A+ TA + E+ +P+ENLLGE G G A+ LD GR+ Sbjct: 178 LVEKGTPGLSFGRPEEKMGLHAAHTAEVRLEEVFVPEENLLGEEGRGLAYALAGLDSGRV 237 Query: 274 GIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAM 333 G+A+QA+GIA+ + + A YAE R FG L + Q I FK+ADM + + +AR L AA Sbjct: 238 GVAAQAVGIARGAFEIAKAYAEEREQFGKKLKEHQAIAFKIADMHVKIAAARALVLEAAR 297 Query: 334 LKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEG 393 KD + FT E++ AKL AS AA ++ +A+Q+LGG GY + ERYYRDA++TEIYEG Sbjct: 298 KKDRGERFTLEASAAKLFASAAAVEVTREAVQVLGGYGYHRDYRVERYYRDAKVTEIYEG 357 Query: 394 TSEIQRLVIAGHLLR 408 TSEIQRLVIA L R Sbjct: 358 TSEIQRLVIARELYR 372 >4O5M-A nrPDB Length = 390 Score = 297 bits (760), Expect = 7e-81, Method: Compositional matrix adjust. Identities = 156/378 (41%), Positives = 224/378 (59%) Query: 34 LPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGL 93 L E + LR T R FAE + P+AA+ D+ + FP ++ GELG+L + PE+ GAG+ Sbjct: 13 LGEEIEALRDTVRRFAESRIAPLAAETDRNNQFPMHLWREFGELGVLGITAPEDYGGAGM 72 Query: 94 DYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFA 153 YLA+ IA+EEISR AS G+ +++L + I + GS +Q+ +++ +G+ +G A Sbjct: 73 GYLAHCIAMEEISRASASIGLSYGAHSNLCVNQITRNGSPEQRAKYLPKLISGEHVGALA 132 Query: 154 LSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAF 213 +SEPG GSD + A + GD +VLNG K WITN +A VV+A TD S +GISAF Sbjct: 133 MSEPGAGSDVVSMKLAAEKRGDRYVLNGNKMWITNGPDADVLVVYAKTDLSAGPRGISAF 192 Query: 214 LVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRI 273 ++ G + +K DKLG+R S+T L+FEDC +P ENLLG G G + M LD R+ Sbjct: 193 IIEKGFKGFSTAQKLDKLGMRGSNTCELVFEDCEVPAENLLGTEGKGVNVLMSGLDYERV 252 Query: 274 GIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAM 333 +A LGI A LD V Y R F P+ + Q +Q KLADM + ++R + A Sbjct: 253 VLAGGPLGIMAACLDVVVPYVHERKQFDQPIGEFQLMQCKLADMYVTFNASRAYVYAVAA 312 Query: 334 LKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEG 393 D + K++A L ++E AT ++ QAIQ LGG GY+ + P R RDA++ EI G Sbjct: 313 ACDRGETTRKDAAGCILYSAENATQMALQAIQSLGGNGYINDYPTGRLLRDAKLYEIGAG 372 Query: 394 TSEIQRLVIAGHLLRSYR 411 TSEI+R++I L + R Sbjct: 373 TSEIRRMLIGRELFQETR 390 >2JIF-A nrPDB Length = 404 Score = 296 bits (759), Expect = 8e-81, Method: Compositional matrix adjust. Identities = 152/371 (40%), Positives = 234/371 (63%), Gaps = 1/371 (0%) Query: 40 MLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYS 99 M++ + + FA++++ P+ + +D+ S ++ + + GL+ ++V E G G +L+ Sbjct: 35 MIKSSVKKFAQEQIAPLVSTMDENSKMEKSVIQGLFQQGLMGIEVDPEYGGTGASFLSTV 94 Query: 100 IALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGN 159 + +EE+++ AS V + N+L I K G+ +QK ++ T +K+G F LSE G Sbjct: 95 LVIEELAKVDASVAVFCEIQNTLINTLIRKHGTEEQKATYLPQLTT-EKVGSFCLSEAGA 153 Query: 160 GSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPT 219 GSD+ A T A +EGD +VLNG+K WI+++ A +V A+ D + KGI++FLV T Sbjct: 154 GSDSFALKTRADKEGDYYVLNGSKMWISSAEHAGLFLVMANVDPTIGYKGITSFLVDRDT 213 Query: 220 PGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQA 279 PGL +GK E+KLG+RASST L FE+ ++P+ N+LG+ G G+K A+ +L+ GRIGIA+Q Sbjct: 214 PGLHIGKPENKLGLRASSTCPLTFENVKVPEANILGQIGHGYKYAIGSLNEGRIGIAAQM 273 Query: 280 LGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKK 339 LG+AQ D + Y + R FG L Q +Q ++A +A LE+ARLLT+ AA L + K Sbjct: 274 LGLAQGCFDYTIPYIKERIQFGKRLFDFQGLQHQVAHVATQLEAARLLTYNAARLLEAGK 333 Query: 340 PFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQR 399 PF KE++MAK ASE A + + I+ +GG+GY + P E+Y+RDA+I IYEG S IQ Sbjct: 334 PFIKEASMAKYYASEIAGQTTSKCIEWMGGVGYTKDYPVEKYFRDAKIGTIYEGASNIQL 393 Query: 400 LVIAGHLLRSY 410 IA H+ Y Sbjct: 394 NTIAKHIDAEY 404 >4KTO-A nrPDB Length = 410 Score = 290 bits (742), Expect = 8e-79, Method: Compositional matrix adjust. Identities = 159/374 (42%), Positives = 226/374 (60%) Query: 34 LPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGL 93 L E LR + R FA + + P+A D+ + FP S ++MGELGLL + E GAGL Sbjct: 33 LGEEIDALRASVRRFASERIAPLADDADRSNAFPMSLWREMGELGLLGITADEAHGGAGL 92 Query: 94 DYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFA 153 YLA+ +A+EEISR AS G+ +++L + I + G QK +++ +G+ +G A Sbjct: 93 GYLAHCVAMEEISRASASVGLSYGAHSNLCVNQINRNGKPAQKSRYLPKLISGEHVGALA 152 Query: 154 LSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAF 213 +SEPG GSD + A + GD +VLNG+K WITN +A VV+A TD + +GI+AF Sbjct: 153 MSEPGAGSDVVSMKLKADKRGDRYVLNGSKMWITNGPDADVLVVYAKTDPAAGPRGITAF 212 Query: 214 LVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRI 273 LV PG + G+K DKLG+R S+T+ LIF DC +P+EN+LG G G K+ M LD R+ Sbjct: 213 LVEKAFPGFSAGQKLDKLGMRGSNTSELIFTDCEVPEENVLGGVGEGVKVLMSGLDYERV 272 Query: 274 GIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAM 333 +++ LGI A LD V Y R FG P+ + Q +Q KLADM + + +AR + A Sbjct: 273 VLSAGPLGIMAACLDVVVPYLHERKQFGQPIGEFQLMQGKLADMYVTMNAARAYVYAVAA 332 Query: 334 LKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEG 393 D + K++A L A+E ATA++ +AIQ LGG GY + PA R RDA++ EI G Sbjct: 333 ACDRGETARKDAAGCILYAAEKATAMALEAIQALGGNGYTNDYPAGRLLRDAKLYEIGAG 392 Query: 394 TSEIQRLVIAGHLL 407 TSEI+R++I L Sbjct: 393 TSEIRRMLIGRELF 406 >2CX9-A nrPDB Length = 387 Score = 288 bits (737), Expect = 3e-78, Method: Compositional matrix adjust. Identities = 177/378 (46%), Positives = 238/378 (62%), Gaps = 5/378 (1%) Query: 36 ETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDY 95 E Q+L R+F + E+ P AA+ D+ FP V+K+ E G+ VPE GAGL Sbjct: 10 EERQVL-GPFREFLKAEVAPGAAERDRTGAFPWDLVRKLAEFGVFGALVPEAYGGAGLST 68 Query: 96 LAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALS 155 ++ +E I+ + + ++ +NSL G IL GS QK+ ++ +G+ +G + L+ Sbjct: 69 RLFARMVEAIAYYDGALALTVASHNSLATGHILLAGSEAQKEAFLPKLASGEALGAWGLT 128 Query: 156 EPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDR----SRQNKGIS 211 EPG+GSDA A T A + W LNGTK +IT A VV A TD R+++GIS Sbjct: 129 EPGSGSDAAALKTKAEKVEGGWRLNGTKQFITQGSVAGVYVVMARTDPPPSPERKHQGIS 188 Query: 212 AFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMG 271 AF P GL +G+KE+KLG+ AS TA LI ED +P+E LLGE G GF ++ LD G Sbjct: 189 AFAFFRPERGLKVGRKEEKLGLTASDTAQLILEDLFVPEEALLGERGKGFYDVLRVLDGG 248 Query: 272 RIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRA 331 RIGIA+ A+G+ QA+LD A+ YA+ R AFG P+ + + + FKLA+ A LE+ARLL +A Sbjct: 249 RIGIAAMAVGLGQAALDYALAYAKGREAFGRPIAEFEGVSFKLAEAATELEAARLLYLKA 308 Query: 332 AMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIY 391 A LKD +PFT E+A AKL ASEAA +AIQILGG GYV + P ERY+RDAR+T I Sbjct: 309 AELKDAGRPFTLEAAQAKLFASEAAVKACDEAIQILGGYGYVKDYPVERYWRDARLTRIG 368 Query: 392 EGTSEIQRLVIAGHLLRS 409 EGTSEI +LVIA LL + Sbjct: 369 EGTSEILKLVIARRLLEA 386 >2A1T-A nrPDB Length = 421 Score = 282 bits (721), Expect = 2e-76, Method: Compositional matrix adjust. Identities = 156/411 (37%), Positives = 238/411 (57%), Gaps = 15/411 (3%) Query: 15 RALRARDWRRLHTVYQ---------SVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHL 65 R++ WR HT S E E + + T R FA +E++P+AA+ DK Sbjct: 13 RSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREEIIPVAAEYDKTGE 72 Query: 66 FPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVN-NSLYL 124 +P +++ ELGL+ +PE G GL + EE++ GC TGV ++ NSL Sbjct: 73 YPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGC--TGVQTAIEGNSLGQ 130 Query: 125 GPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKA 184 PI+ G+ QQK++++ T + + ++EPG GSD T A ++GD +++NG K Sbjct: 131 MPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKM 190 Query: 185 WITNSWEASATVVFASTD---RSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANL 241 WITN +A+ + A +D ++ NK + F+V TPG+ +G+KE +G R S T + Sbjct: 191 WITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGI 250 Query: 242 IFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFG 301 +FED ++PKEN+L G GFK+AM D R +A+ A+G+AQ +LD A KYA R FG Sbjct: 251 VFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFG 310 Query: 302 APLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISH 361 L + Q I F LA+MA+ +E AR+ RAA D+ + T +++AK A + A ++ Sbjct: 311 KLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLAT 370 Query: 362 QAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRSYRS 412 A+QILGG G+ TE P E+ RDA+I +IYEGTS+IQRL++A + Y++ Sbjct: 371 DAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN 421 >3MDE-A nrPDB Length = 385 Score = 280 bits (715), Expect = 1e-75, Method: Compositional matrix adjust. Identities = 150/385 (38%), Positives = 233/385 (60%), Gaps = 6/385 (1%) Query: 31 SVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSG 90 S EL E + + T R FA +E++P+AA+ D+ +P +K+ ELGL+ +PE G Sbjct: 3 SFELTEQQKEFQATARKFAREEIIPVAAEYDRTGEYPVPLLKRAWELGLMNTHIPESFGG 62 Query: 91 AGLDYLAYSIALEEISRGCASTGVIMSVN-NSLYLGPILKFGSSQQKQQWITPFTNGDKI 149 GL + + EE++ GC TGV ++ N+L P++ G+ QQ+++++ T + Sbjct: 63 LGLGIIDSCLITEELAYGC--TGVQTAIEANTLGQVPLIIGGNYQQQKKYLGRMTEEPLM 120 Query: 150 GCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTD---RSRQ 206 + ++EPG GSD T A ++GD +++NG K WITN +A+ + A +D ++ Sbjct: 121 CAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPA 180 Query: 207 NKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQ 266 +K + F+V TPG+ +G+KE +G R S T ++FED R+PKEN+L G GFKIAM Sbjct: 181 SKAFTGFIVEADTPGVQIGRKEINMGQRCSDTRGIVFEDVRVPKENVLTGEGAGFKIAMG 240 Query: 267 TLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARL 326 T D R +A+ A+G+AQ +LD A KYA R FG L + Q I F LADMA+ +E ARL Sbjct: 241 TFDKTRPPVAAGAVGLAQRALDEATKYALERKTFGKLLAEHQGISFLLADMAMKVELARL 300 Query: 327 LTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDAR 386 RAA D+ + T +++AK A++ A ++ A+Q+ GG G+ TE P E+ RDA+ Sbjct: 301 SYQRAAWEIDSGRRNTYYASIAKAYAADIANQLATDAVQVFGGNGFNTEYPVEKLMRDAK 360 Query: 387 ITEIYEGTSEIQRLVIAGHLLRSYR 411 I +IYEGT++IQR++IA + Y+ Sbjct: 361 IYQIYEGTAQIQRIIIAREHIGRYK 385 >3NF4-A nrPDB Length = 387 Score = 273 bits (697), Expect = 1e-73, Method: Compositional matrix adjust. Identities = 153/368 (41%), Positives = 231/368 (62%), Gaps = 3/368 (0%) Query: 41 LRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSI 100 L + R+ A+K L PI + +K+ +P +++G GLL++ PEE G G Y Y Sbjct: 23 LIELTREIADKVLDPIVDRHEKDETYPEGVFEQLGAAGLLSLPQPEEWGGGGQPYEVYLQ 82 Query: 101 ALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNG 160 LEEI+ AS V +SV+ SL P+L FG+ +QK++W+ +G++IG ++LSEP G Sbjct: 83 VLEEIAARWASVAVAVSVH-SLSSHPLLVFGTEEQKKRWLPGMLSGEQIGAYSLSEPQAG 141 Query: 161 SDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTP 220 SDA A A +V+NG+K+WIT+ +A +FA T ++G+S FLVP P Sbjct: 142 SDAAALRCAATPTDGGYVINGSKSWITHGGKADFYTLFARTGEG--SRGVSCFLVPADQP 199 Query: 221 GLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQAL 280 GL+ GK E+K+G+ A T + +++ RI + +GE G G +IA LD GR+GIA+ A Sbjct: 200 GLSFGKPEEKMGLHAVPTTSAFYDNARIDADRRIGEEGQGLQIAFSALDSGRLGIAAVAT 259 Query: 281 GIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKP 340 G+AQA+LD AV YA R AFG + Q + F LADMA A+ +AR AA +D +P Sbjct: 260 GLAQAALDEAVAYANERTAFGRKIIDHQGLGFLLADMAAAVATARATYLDAARRRDQGRP 319 Query: 341 FTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRL 400 +++++++AKL A++AA ++ A+Q+ GG+GY + ERY R+A+I +I+EGT++IQRL Sbjct: 320 YSQQASIAKLTATDAAMKVTTDAVQVFGGVGYTRDYRVERYMREAKIMQIFEGTNQIQRL 379 Query: 401 VIAGHLLR 408 VIA L R Sbjct: 380 VIARGLTR 387 >2Z1Q-A nrPDB Length = 577 Score = 266 bits (681), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 153/398 (38%), Positives = 229/398 (57%), Gaps = 22/398 (5%) Query: 28 VYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHL-FPTSQVKKMGELGLLAMDVPE 86 VY + E+ + + +T R F E+E++P+ +++ L ++K GELGLLA+DVPE Sbjct: 22 VYTPEDFDESVKEIARTTRTFVEREVLPLLERMEHGELELNVPLMRKAGELGLLAIDVPE 81 Query: 87 ELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNG 146 E G L + ++ EE+S G V + S+ P++ FG+ +QK++++ +G Sbjct: 82 EYGGLDLPKVISTVVAEELS-GSGGFSVTYGAHTSIGTLPLVYFGTEEQKRKYLPKLASG 140 Query: 147 DKIGCFALSEPGNGSDAGAAST--TAREEGDSWVLNGTKAWITNSWEASATVVFASTDRS 204 + I + L+EPG+GSDA AA T T E+G ++LNG K WI+N+ A VFA D Sbjct: 141 EWIAAYCLTEPGSGSDALAAKTRATLSEDGKHYILNGVKQWISNAGFAHLFTVFAKVD-- 198 Query: 205 RQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIA 264 + +AFLV TPGL+ G +E K+GI+ASST +I ED ++P EN+LGE G G KIA Sbjct: 199 --GEHFTAFLVERDTPGLSFGPEEKKMGIKASSTRQVILEDVKVPVENVLGEIGKGHKIA 256 Query: 265 MQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESA 324 L++GR + + A+G A+ +L+ + +YA R FG P+ + IQ KL +MA + +A Sbjct: 257 FNVLNVGRYKLGAGAVGGAKRALELSAQYATQRVQFGRPIGRFGLIQQKLGEMASRIYAA 316 Query: 325 RLLTWRAAMLKD-----NKKP---------FTKESAMAKLAASEAATAISHQAIQILGGM 370 +R L D K P + E+++ K+ SE + + +QI GG Sbjct: 317 ESAVYRTVGLIDEALLGKKGPEAVMAGIEEYAVEASIIKVLGSEVLDYVVDEGVQIHGGY 376 Query: 371 GYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLR 408 GY E P ER YRDARI I+EGT+EI RL+I G LLR Sbjct: 377 GYSQEYPIERAYRDARINRIFEGTNEINRLLIPGMLLR 414 >1RX0-A nrPDB Length = 393 Score = 265 bits (677), Expect = 3e-71, Method: Compositional matrix adjust. Identities = 144/379 (37%), Positives = 229/379 (60%), Gaps = 3/379 (0%) Query: 31 SVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSG 90 S+ L E + ++ DFA +E+ P A+ D++ LFP ++K +LG + + ++ G Sbjct: 16 SMGLNEEQKEFQKVAFDFAAREMAPNMAEWDQKELFPVDVMRKAAQLGFGGVYIQTDVGG 75 Query: 91 AGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIG 150 +GL L S+ E ++ GC ST +S++N + I FG+ +Q+ ++ P +K Sbjct: 76 SGLSRLDTSVIFEALATGCTSTTAYISIHN-MCAWMIDSFGNEEQRHKFCPPLCTMEKFA 134 Query: 151 CFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGI 210 + L+EPG+GSDA + T+A+++GD ++LNG+KA+I+ + E+ VV T KGI Sbjct: 135 SYCLTEPGSGSDAASLLTSAKKQGDHYILNGSKAFISGAGESDIYVVMCRTG-GPGPKGI 193 Query: 211 SAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDM 270 S +V TPGL+ GKKE K+G + T +IFEDC +P N +G G GF IA++ L+ Sbjct: 194 SCIVVEKGTPGLSFGKKEKKVGWNSQPTRAVIFEDCAVPVANRIGSEGQGFLIAVRGLNG 253 Query: 271 GRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWR 330 GRI IAS +LG A AS+ + R FG PL Q +QF LADMA L +ARL+ Sbjct: 254 GRINIASCSLGAAHASVILTRDHLNVRKQFGEPLASNQYLQFTLADMATRLVAARLMVRN 313 Query: 331 AAM-LKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITE 389 AA+ L++ +K +MAKL A++ AI +QA+Q+ GG GY+ + ++Y RD+R+ + Sbjct: 314 AAVALQEERKDAVALCSMAKLFATDECFAICNQALQMHGGYGYLKDYAVQQYVRDSRVHQ 373 Query: 390 IYEGTSEIQRLVIAGHLLR 408 I EG++E+ R++I+ LL+ Sbjct: 374 ILEGSNEVMRILISRSLLQ 392 >1IVH-A nrPDB Length = 394 Score = 265 bits (677), Expect = 3e-71, Method: Compositional matrix adjust. Identities = 139/374 (37%), Positives = 215/374 (57%), Gaps = 4/374 (1%) Query: 34 LPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQV--KKMGELGLLAMDVPEELSGA 91 L E + LRQT F ++ L P A ++D+ + F + K++G LG+L + P + G+ Sbjct: 13 LSEEQRQLRQTMAKFLQEHLAPKAQEIDRSNEFKNLREFWKQLGNLGVLGITAPVQYGGS 72 Query: 92 GLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGC 151 GL YL + + +EEISR + G+ +++L + +++ G+ QK++++ +G+ IG Sbjct: 73 GLGYLEHVLVMEEISRASGAVGLSYGAHSNLCINQLVRNGNEAQKEKYLPKLISGEYIGA 132 Query: 152 FALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSR--QNKG 209 A+SEP GSD + A ++G+ ++LNG K WITN +A +V+A TD + ++G Sbjct: 133 LAMSEPNAGSDVVSMKLKAEKKGNHYILNGNKFWITNGPDADVLIVYAKTDLAAVPASRG 192 Query: 210 ISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLD 269 I+AF+V PG + KK DKLG+R S+T LIFEDC+IP N+LG G + M LD Sbjct: 193 ITAFIVEKGMPGFSTSKKLDKLGMRGSNTCELIFEDCKIPAANILGHENKGVYVLMSGLD 252 Query: 270 MGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTW 329 + R+ +A LG+ QA LD + Y R AFG + Q +Q K+ADM L + R + Sbjct: 253 LERLVLAGGPLGLMQAVLDHTIPYLHVREAFGQKIGHFQLMQGKMADMYTRLMACRQYVY 312 Query: 330 RAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITE 389 A D K+ A L ++E AT ++ IQ GG GY+ + P R+ RDA++ E Sbjct: 313 NVAKACDEGHCTAKDCAGVILYSAECATQVALDGIQCFGGNGYINDFPMGRFLRDAKLYE 372 Query: 390 IYEGTSEIQRLVIA 403 I GTSE++RLVI Sbjct: 373 IGAGTSEVRRLVIG 386 >3MPI-A nrPDB Length = 397 Score = 257 bits (656), Expect = 7e-69, Method: Compositional matrix adjust. Identities = 148/375 (39%), Positives = 230/375 (61%), Gaps = 6/375 (1%) Query: 34 LPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQ-VKKMGELGLLAMDVPEELSGAG 92 L + QML++ R+F K++VP A Q D E+ FP + V+ MGELG +PEE G G Sbjct: 5 LSKELQMLQKEVRNFVNKKIVPFADQWDNENHFPYEEAVRPMGELGFFGTVIPEEYGGEG 64 Query: 93 LD--YLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIG 150 +D +LA I EEI+RG ++ V +++ IL +GS K++++ ++ + +G Sbjct: 65 MDQGWLAAMIVTEEIARGSSALRVQLNMEVLGCAYTILTYGSEALKKKYVPKLSSAEFLG 124 Query: 151 CFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGI 210 F ++EP GSD A S+TA ++GD W+LNG+K WI+N+ +A + +A TD++ ++G+ Sbjct: 125 GFGITEPDAGSDVMAMSSTAEDKGDHWLLNGSKTWISNAAQADVLIYYAYTDKAAGSRGL 184 Query: 211 SAFLV-PMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLD 269 SAF++ P PG+ E KLG AS T L ++ ++PKEN+LG+PG G +I +L+ Sbjct: 185 SAFVIEPRNFPGIKTSNLE-KLGSHASPTGELFLDNVKVPKENILGKPGDGARIVFGSLN 243 Query: 270 MGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTW 329 R+ A+ +G+AQA LD A+KY R FG P+ Q Q +A MA+ +E+ARLL + Sbjct: 244 HTRLSAAAGGVGLAQACLDAAIKYCNERRQFGKPIGDFQMNQDMIAQMAVEVEAARLLAY 303 Query: 330 RAAMLKDNKKPFTK-ESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARIT 388 +AA KD + + AMAK AA EA + ++ A++ILG GY TE P R+YRDA Sbjct: 304 KAAAAKDEGRLNNGLDVAMAKYAAGEAVSKCANYAMRILGAYGYSTEYPVARFYRDAPTY 363 Query: 389 EIYEGTSEIQRLVIA 403 + EG++ I +++IA Sbjct: 364 YMVEGSANICKMIIA 378 >3OWA-A nrPDB Length = 597 Score = 251 bits (640), Expect = 6e-67, Method: Compositional matrix adjust. Identities = 150/415 (36%), Positives = 225/415 (54%), Gaps = 37/415 (8%) Query: 21 DWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQ--VKKMGELG 78 D + V+ + H+M+ +T DF E++P L+ +H F S +K+ GELG Sbjct: 20 DEITIDQVFTPEDFSSEHKMIAKTTEDFIVNEVLPELEYLE-QHEFDRSVRLLKEAGELG 78 Query: 79 LLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLG----PILKFGSSQ 134 LL DVPEE G GLD ++ ++ E+ SR ++ + ++G PI+ FG+ + Sbjct: 79 LLGADVPEEYGGIGLDKVSSALIAEKFSRAGG-----FAITHGAHVGIGSLPIVLFGNEE 133 Query: 135 QKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAR--EEGDSWVLNGTKAWITNSWEA 192 QK++++ G+K+ +AL+EPG+GSDA A TTAR EG +VLNG K WITNS A Sbjct: 134 QKKKYLPLLATGEKLAAYALTEPGSGSDALGAKTTARLNAEGTHYVLNGEKQWITNSAFA 193 Query: 193 SATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKEN 252 +V+A D + SAF+V G++ +E K+GI+ SST LI ED +PKEN Sbjct: 194 DVFIVYAKID----GEHFSAFIVEKDYAGVSTSPEEKKMGIKCSSTRTLILEDALVPKEN 249 Query: 253 LLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQF 312 LLGE G G IA L++GR + +G A+ +++ + +YA R F P+ + IQ Sbjct: 250 LLGEIGKGHIIAFNILNIGRYKLGVGTVGSAKRAVEISAQYANQRQQFKQPIARFPLIQE 309 Query: 313 KLADMA-------------LALESARLLTWRAAMLKDNK------KPFTKESAMAKLAAS 353 KLA+MA + L +R+ T +KD K + E ++ K+ S Sbjct: 310 KLANMAAKTYAAESSVYRTVGLFESRMSTLSEEEVKDGKAVAASIAEYAIECSLNKVFGS 369 Query: 354 EAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLR 408 E + +QI GG G++ E ER YRD+RI I+EGT+EI RL++ G LR Sbjct: 370 EVLDYTVDEGVQIHGGYGFMAEYEIERMYRDSRINRIFEGTNEINRLIVPGTFLR 424 >4IV6-A nrPDB Length = 388 Score = 238 bits (607), Expect = 3e-63, Method: Compositional matrix adjust. Identities = 135/380 (35%), Positives = 215/380 (56%), Gaps = 5/380 (1%) Query: 31 SVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSG 90 S+ L + + +T DF EK++ P+ +L+ + +P ++ M E+G+ + +PE Sbjct: 4 SMALTAEEETIVKTVHDFVEKQVKPVVRELEHANTYPEELIETMKEIGIFGLAIPEPYGF 63 Query: 91 AGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIG 150 + Y EE++RG S M +++ +L FG+ +QKQ+++ G+ Sbjct: 64 GAVSMPCYVQVAEELARGWMSLAGAMG-GHTVVSKLLLLFGTEEQKQKYLPRMATGELRA 122 Query: 151 CFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQ--NK 208 AL+EPG GSD A T AR +GD +V+NG+K WI+N+ + + TD Q +K Sbjct: 123 TMALTEPGGGSDLQAMRTVARRDGDDYVINGSKTWISNARRSDLVALMCKTDPDAQPAHK 182 Query: 209 GISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEP-GMGFKIAMQT 267 G+S LV PG + + KLG + + L F D R+P +LLG+ G GF M+ Sbjct: 183 GVSILLVE-KVPGFDVSRDLPKLGYKGVESCELNFTDARVPVSSLLGDDEGRGFAQMMKG 241 Query: 268 LDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLL 327 L++GR+ +A++A G+A+A+ + A++Y++ R +FG P+ + Q++ LADM L +AR L Sbjct: 242 LEVGRLQVAARATGVARAAFEDALRYSQERESFGKPIWQHQSVGNMLADMGTKLYAARSL 301 Query: 328 TWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARI 387 AA D + E+ MAKL ASE A I+ A+++ GG GY TE ERY+RDA + Sbjct: 302 LLSAAEKFDAGQRCDMEAGMAKLFASETAMQIALDAVRVHGGYGYSTEYDVERYFRDAPL 361 Query: 388 TEIYEGTSEIQRLVIAGHLL 407 + EGT+EIQR VIA L+ Sbjct: 362 MIVGEGTNEIQRNVIAKQLV 381 >2PG0-A nrPDB Length = 385 Score = 236 bits (602), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 136/375 (36%), Positives = 199/375 (53%), Gaps = 3/375 (0%) Query: 34 LPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGL 93 L E H M R R F EKE P +K + P S KMGE G L V E+ G Sbjct: 10 LREEHHMFRAAFRKFLEKEAYPHYNDWEKRGIIPRSFWAKMGENGFLCPWVDEKYGGLNA 69 Query: 94 DYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFA 153 D+ AYS+ + E S+ V + ++N + I +G+ +QKQ+W+ G+ I A Sbjct: 70 DF-AYSVVINEELEKVGSSLVGIGLHNDIVTPYIASYGTEEQKQKWLPKCVTGELITAIA 128 Query: 154 LSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQ--NKGIS 211 ++EPG GSD STTA ++GD +++NG K +ITN A VV TD + ++GIS Sbjct: 129 MTEPGAGSDLANISTTAVKDGDYYIVNGQKTFITNGIHADLIVVACKTDPQAKPPHRGIS 188 Query: 212 AFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMG 271 +V TPG T G+K +K+G+ A TA L F+D ++P NLLGE G GF M+ L Sbjct: 189 LLVVERDTPGFTRGRKLEKVGLHAQDTAELFFQDAKVPAYNLLGEEGKGFYYLMEKLQQE 248 Query: 272 RIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRA 331 R+ +A A A+ +Y + R AFG +++ Q +QF+LA+MA + R R Sbjct: 249 RLVVAIAAQTAAEVMFSLTKQYVKQRTAFGKRVSEFQTVQFRLAEMATEIALGRTFVDRV 308 Query: 332 AMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIY 391 K E +MAK +E A ++ +A+Q+ GG GY+ E R YRD ++ IY Sbjct: 309 IEEHMAGKQIVTEVSMAKWWITEMAKRVAAEAMQLHGGYGYMEEYEIARRYRDIPVSAIY 368 Query: 392 EGTSEIQRLVIAGHL 406 GT+E+ + +IA L Sbjct: 369 AGTNEMMKTIIARQL 383 >6ES9-A nrPDB Length = 551 Score = 230 bits (587), Expect = 7e-61, Method: Compositional matrix adjust. Identities = 150/420 (35%), Positives = 222/420 (52%), Gaps = 16/420 (3%) Query: 2 AAALLARAGGSLGRALRARDWRRLH--TVYQSVELPETHQMLRQTCRDFAEKELVPIAAQ 59 AAA L R + RA AR + H + + L E +M+R R +AE+ ++P A + Sbjct: 133 AAAKLMRGNTAPARAELARLMQDNHGRATFGATGLDEDLEMIRDQFRRYAEERVIPNAHE 192 Query: 60 LD-KEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSV 118 K+ L P ++++ ELG+ + +PEE G GL + + EE+SRG G + Sbjct: 193 WHLKDQLIPMEIIEELAELGVFGLTIPEEFGGLGLSKASMVVVTEELSRGYIGVGS-LGT 251 Query: 119 NNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWV 178 + + IL G+ QK +W+ +G+ + +EP GSD G+ T A +G+ WV Sbjct: 252 RSEIAAELILCGGTEAQKAKWLPGLASGEILSTAVFTEPNTGSDLGSLRTRAVRDGEDWV 311 Query: 179 LNGTKAWITNSWEASATVVFASTDRSRQN-KGISAFLV---------PMPTPGLTLGKKE 228 + G K WIT++ + A TD + +G+S FL P PTPG+T G+ E Sbjct: 312 VTGNKTWITHAQRTHVMTLLARTDPETTDWRGLSMFLAEKEPGTDDDPFPTPGMTGGEIE 371 Query: 229 DKLGIRASSTANLIFEDCRIPKENLLG-EPGMGFKIAMQTLDMGRIGIASQALGIAQASL 287 LG R L F+ RI ENLLG EPG GFK M+T + RI A++A+G+AQ++ Sbjct: 372 -VLGYRGMKEYELGFDGFRIKGENLLGGEPGRGFKQLMETFESARIQTAARAVGVAQSAA 430 Query: 288 DCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAM 347 + ++YA +R FG L + + KLA MA+ + AR LT+ +A KD+ + E+ M Sbjct: 431 EIGMRYAVDRKQFGKSLIEFPRVADKLAMMAVEIMIARQLTYFSAWEKDHGRRCDLEAGM 490 Query: 348 AKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLL 407 AKL + A A + A+QI GG G+ E R DARI I+EG +EIQ VIA LL Sbjct: 491 AKLLGARVAWAAADNALQIHGGNGFALEYAISRVLCDARILNIFEGAAEIQAQVIARRLL 550 >4IRN-A nrPDB Length = 416 Score = 227 bits (578), Expect = 9e-60, Method: Compositional matrix adjust. Identities = 127/368 (34%), Positives = 202/368 (54%), Gaps = 2/368 (0%) Query: 41 LRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSI 100 R+ FA++ L+ + DKE +F +K E G+ +P G LD L + Sbjct: 47 FRKKVIQFAQQSLISDLIKNDKEEIFNRDAWQKCSEFGVHGWPIPARYGGQELDILTTAY 106 Query: 101 ALEEISRGCASTGVIMSVNNSLYLG--PILKFGSSQQKQQWITPFTNGDKIGCFALSEPG 158 AL+ + GC G+I ++N ++ P+L FG+ +QK++++ G I A +EP Sbjct: 107 ALQGLGYGCKDNGLIFAMNAHIWACEMPLLTFGTEEQKEKYLPLLCRGGWIASHAATEPQ 166 Query: 159 NGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMP 218 GSD + TTA+++GD ++LNG K ++TN A ++FA+ D S +G++ F++ Sbjct: 167 AGSDIYSLKTTAQKDGDKYILNGYKHYVTNGTIADLFIIFATIDPSLGKEGLTTFMIEKD 226 Query: 219 TPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQ 278 TPGL L K K+G+R + L E+C + N LGE G G I +++ R I + Sbjct: 227 TPGLILSKPISKMGMRTAEVPELRLENCEVSAANRLGEEGTGLAIFNHSMEWERGFILAA 286 Query: 279 ALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNK 338 A+G + L+ +++YA + FG + K Q + KL +M L LE+A+ ++ A +K+NK Sbjct: 287 AVGTMERLLEQSIRYARSHKQFGQAIGKFQLVANKLVEMKLRLENAKAYLYKVAWMKENK 346 Query: 339 KPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQ 398 + E++MA L SEA +AI+I G GY+T ER RDA ++ Y GTSEIQ Sbjct: 347 QMALLEASMANLYISEAWVQSCLEAIEIHGAYGYLTNTELERELRDAIASKFYSGTSEIQ 406 Query: 399 RLVIAGHL 406 R+VIA L Sbjct: 407 RVVIAKFL 414 >5IDU-A nrPDB Length = 410 Score = 223 bits (569), Expect = 9e-59, Method: Compositional matrix adjust. Identities = 137/345 (39%), Positives = 196/345 (56%), Gaps = 10/345 (2%) Query: 71 VKKMGELGLLAMDVP-EELSGAG--LDYLAYSIALEEISR--GCASTGVIMSVNNSLYLG 125 V+ +GE G L V + G G +D A + E ++ G A + M L G Sbjct: 61 VRALGEAGWLKYGVGGAQYGGHGDTIDTRAVCLLRETLANHDGLADFALAM---QGLGSG 117 Query: 126 PILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAW 185 I G+ +QK +++ + G+ I FALSEP GSD A S AR EGD +V++G K W Sbjct: 118 AITLAGTHEQKIRYLPRVSKGEAIAAFALSEPDAGSDVAAMSLQARAEGDCYVIDGDKTW 177 Query: 186 ITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFED 245 I+N A VVFA T + +GISAF+V TPGL + ++ D I A L F+ Sbjct: 178 ISNGGIADFYVVFARTGEAPGARGISAFIVDADTPGLQIAERIDV--IAPHPLARLHFDS 235 Query: 246 CRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLT 305 R+P+ +LG PG GFKIAM+TLD+ R +A+ +LG A+ +L + A +R FG L Sbjct: 236 ARVPRSQMLGAPGEGFKIAMRTLDVFRTSVAAASLGFARRALQEGLARAASRKMFGQTLG 295 Query: 306 KLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQ 365 Q Q KLA MAL ++S+ LL +RAA L+D + T+E+AMAK ASE A + A+Q Sbjct: 296 DFQLTQTKLAQMALTIDSSALLVYRAAWLRDQGENVTREAAMAKWHASEGAQQVIDAAVQ 355 Query: 366 ILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRSY 410 + GGMG + ER YR+ R IYEG +E+Q+L++ LL+++ Sbjct: 356 LWGGMGVQSGTTVERLYREIRALRIYEGATEVQQLIVGRDLLKAH 400 >5JSC-A nrPDB Length = 410 Score = 219 bits (558), Expect = 2e-57, Method: Compositional matrix adjust. Identities = 121/284 (42%), Positives = 171/284 (60%), Gaps = 2/284 (0%) Query: 125 GPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKA 184 G I G+ +QK +++ NG I FALSEP GSD A + +ARE+GD++VL+G K Sbjct: 117 GAISLGGTHEQKTRYLPRVANGTAIAAFALSEPEAGSDVAAMTLSAREDGDAYVLDGDKT 176 Query: 185 WITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFE 244 WI+N A VVFA T + +GISAF+V TPGL + ++ D I A L F Sbjct: 177 WISNGGIADFYVVFARTGEAPGARGISAFVVDADTPGLEIAERIDV--IAPHPLARLHFA 234 Query: 245 DCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPL 304 R+P+ +LG PG GFK+AM+TLD+ R +A+ +LG A+ ++ V A +R FG L Sbjct: 235 GARVPRSQMLGAPGEGFKLAMRTLDIFRTSVAAASLGFARHAMAEGVARAASRKMFGQTL 294 Query: 305 TKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAI 364 Q Q KLA MAL ++S+ LL +RAA L+D + T+E+AMAK ASE A + A+ Sbjct: 295 GDFQLTQAKLAQMALTIDSSALLVYRAAWLRDQGENVTREAAMAKWHASEGAQQVIDAAV 354 Query: 365 QILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLR 408 Q+ GGMG + E YR+ R IYEG +E+Q+L++ LL+ Sbjct: 355 QLYGGMGVQSGTAVEMLYREIRALRIYEGATEVQQLIVGRDLLK 398 >3B96-A nrPDB Length = 587 Score = 214 bits (546), Expect = 4e-56, Method: Compositional matrix adjust. Identities = 136/387 (35%), Positives = 204/387 (52%), Gaps = 15/387 (3%) Query: 29 YQSVELPETHQMLRQ----TCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDV 84 Y SV E Q L++ R F E V A+ D + + + + ELG + V Sbjct: 22 YPSVLNEEQTQFLKELVEPVSRFFEE---VNDPAKNDALEMVEETTWQGLKELGAFGLQV 78 Query: 85 PEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFT 144 P EL G GL Y+ +E + G+ + + S+ IL FG+ QK++++ Sbjct: 79 PSELGGVGLCNTQYARLVEIVGMHDLGVGITLGAHQSIGFKGILLFGTKAQKEKYLPKLA 138 Query: 145 NGDKIGCFALSEPGNGSDAGAASTTAREE--GDSWVLNGTKAWITNSWEASATVVFASTD 202 +G+ + F L+EP +GSDA + T+A G + LNG+K WI+N A VFA T Sbjct: 139 SGETVAAFCLTEPSSGSDAASIRTSAVPSPCGKYYTLNGSKLWISNGGLADIFTVFAKTP 198 Query: 203 RSRQNKG-----ISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEP 257 + G I+AF+V G+T G E K+GI+AS+TA + F+ R+P EN+LGE Sbjct: 199 VTDPATGAVKEKITAFVVERGFGGITHGPPEKKMGIKASNTAEVFFDGVRVPSENVLGEV 258 Query: 258 GMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADM 317 G GFK+AM L+ GR G+A+ G + + AV +A NR FG + IQ KLA M Sbjct: 259 GSGFKVAMHILNNGRFGMAAALAGTMRGIIAKAVDHATNRTQFGEKIHNFGLIQEKLARM 318 Query: 318 ALALESARLLTWR-AAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEM 376 + + + +A + F E+A++K+ SEAA ++ + IQI+GGMG++ E Sbjct: 319 VMLQYVTESMAYMVSANMDQGATDFQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEP 378 Query: 377 PAERYYRDARITEIYEGTSEIQRLVIA 403 ER RD RI I+EGT++I RL +A Sbjct: 379 GVERVLRDLRIFRIFEGTNDILRLFVA 405 >2EBA-A nrPDB Length = 385 Score = 209 bits (533), Expect = 1e-54, Method: Compositional matrix adjust. Identities = 136/369 (36%), Positives = 195/369 (52%), Gaps = 7/369 (1%) Query: 35 PETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLD 94 PE ++ ++ R F EKE +P +E +FPT + + ELG L +P E GAG+ Sbjct: 13 PEEKEV-QKAARRFLEKEALPHIRDWWEEGVFPTHLIPRFAELGFLGPTLPPEYGGAGVS 71 Query: 95 YLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFAL 154 AY + E+ R + +SV +SL + PI +GS +QK++++ G+ +GCF L Sbjct: 72 SAAYGLICYELERVDSGLRSFVSVQSSLVMYPIYAYGSEEQKREFLPKLARGEMVGCFGL 131 Query: 155 SEPGNGSDA-GAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAF 213 +EP GSD G T AR EGD+WVLNGTK WITN A V++A + + F Sbjct: 132 TEPDGGSDPYGNMKTRARREGDTWVLNGTKMWITNGNLAHLAVIWAKDEGGE----VLGF 187 Query: 214 LVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRI 273 LVP TPG + + K+ +RAS T+ L+ E+ R+P E+L +G K + L R Sbjct: 188 LVPTDTPGFQAREVKRKMSLRASVTSELVLEEVRVP-ESLRLPKALGLKAPLSCLTQARF 246 Query: 274 GIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAM 333 GIA A+G +A + AV +A++R FG PL K Q +Q KLA+M LL WR A Sbjct: 247 GIAWGAMGALEAVYEEAVAFAKSRSTFGEPLAKKQLVQAKLAEMLAWHTEGLLLAWRLAR 306 Query: 334 LKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEG 393 LKD K + ++AK A + A ILGG G E A R+ + YEG Sbjct: 307 LKDEGKLTPAQVSLAKRQNVWKALQAARMARDILGGSGITLEYHAIRHMLNLETVYTYEG 366 Query: 394 TSEIQRLVI 402 T ++ LV+ Sbjct: 367 THDVHTLVL 375 >3SWO-A nrPDB Length = 399 Score = 207 bits (528), Expect = 5e-54, Method: Compositional matrix adjust. Identities = 131/387 (33%), Positives = 190/387 (49%), Gaps = 14/387 (3%) Query: 27 TVYQSVELPETHQMLRQ-------TCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGL 79 + Y +EL +T ++L Q T R F + L P + P+ K+ G LG+ Sbjct: 12 STYAPLELFDTDRLLDQDERDIAATVRQFVDTRLKPNVEGWFESATLPSELAKEFGNLGV 71 Query: 80 LAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQW 139 L M + + AG + ++Y +A E+ G + +SV SL + I ++GS +QK +W Sbjct: 72 LGMHL-QGYGCAGTNAVSYGLACMELEAGDSGFRSFVSVQGSLSMFSIYRYGSEEQKNEW 130 Query: 140 ITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFA 199 + GD IGCF L+EP GS+ T AR +G W+LNGTK WITN A V+A Sbjct: 131 LPRLAAGDAIGCFGLTEPDFGSNPAGMRTRARRDGSDWILNGTKMWITNGNLADVATVWA 190 Query: 200 STDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGM 259 TD GI FLVP TPG T + KL +RAS T+ L+ ++ R+P L Sbjct: 191 QTD-----DGIRGFLVPTDTPGFTANEIHRKLSLRASVTSELVLDNVRLPASAQL-PLAE 244 Query: 260 GFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMAL 319 G + L+ R GI ALG A+ SL+ + Y ++R F PL+ Q Q KLA+M + Sbjct: 245 GLSAPLSCLNEARFGIVFGALGAARDSLETTIAYTQSREVFDKPLSNYQLTQEKLANMTV 304 Query: 320 ALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAE 379 L LL +KD + ++ ++ KL A AI+ + +LGG G E Sbjct: 305 ELGKGMLLAIHLGRIKDAEGVRPEQISLGKLNNVREAIAIARECRTLLGGSGITLEYSPL 364 Query: 380 RYYRDARITEIYEGTSEIQRLVIAGHL 406 R+ + YEGTSE+ L I L Sbjct: 365 RHANNLESVLTYEGTSEMHLLSIGKAL 391 >3R7K-A nrPDB Length = 403 Score = 205 bits (522), Expect = 3e-53, Method: Compositional matrix adjust. Identities = 135/371 (36%), Positives = 191/371 (51%), Gaps = 5/371 (1%) Query: 35 PETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLD 94 PE + L Q R F E+E+ P A+ + P E+GLL + PEE+ G+G + Sbjct: 31 PE-RRALSQMARSFVEREIAPKLAEWEHVGEIPRDLHLNAAEVGLLGIGFPEEVGGSGGN 89 Query: 95 YLAYSIALEEISRGCASTGVIMSV-NNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFA 153 + ++ E I STGV ++ + + L I GS ++++ P G IG Sbjct: 90 AIDSALVTEAILAAGGSTGVCAALFTHGIALPHIAANGSDALIERYVRPTLAGKMIGSLG 149 Query: 154 LSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAF 213 ++EPG GSD T A EGD++V+NG K +IT+ A T G+S Sbjct: 150 VTEPGAGSDVANLRTRAVREGDTYVVNGAKTFITSGVRADFVTTAVRTG-GPGYGGVSLL 208 Query: 214 LVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRI 273 ++ +PG + ++ DK+G R S TA L F D R+P +NL+G GF MQ R+ Sbjct: 209 VIDKNSPGFEVSRRLDKMGWRCSDTAELSFVDVRVPADNLVGAENSGFLQIMQQFQAERL 268 Query: 274 GIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAM 333 GIA QA A +LD A +A R FG PLT Q I+ KLA+MA ++ A T RA M Sbjct: 269 GIAVQAYATAGRALDLAKSWARERETFGRPLTGRQIIRHKLAEMARQVDVACTYT-RAVM 327 Query: 334 LK-DNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYE 392 + + E +MAK A A + ++A+QI GGMGY+ E ER+YRD RI I Sbjct: 328 QRWLAGEDVVAEVSMAKNTAVYACDYVVNEAVQIFGGMGYMRESEIERHYRDCRILGIGG 387 Query: 393 GTSEIQRLVIA 403 GT+EI VIA Sbjct: 388 GTNEIMNEVIA 398 >3SF6-A nrPDB Length = 403 Score = 204 bits (520), Expect = 4e-53, Method: Compositional matrix adjust. Identities = 128/365 (35%), Positives = 184/365 (50%), Gaps = 10/365 (2%) Query: 41 LRQTCRDFAEKELVPIAAQLDKEHLFPTSQVK-KMGELGLLAMDVPEELSGAGLDYLAYS 99 +R T R ++ + P A ++ P ++ ++GELGLL M + + AG+ +AY Sbjct: 37 IRDTVRSVVQRRIKPHIASWYEDGELPARELAVELGELGLLGMHL-KGYGCAGMSAVAYG 95 Query: 100 IALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGN 159 +A E+ G + ++SV SL + I FGS +QK QW+ +G +IGCF L+EP + Sbjct: 96 LACLELEAGDSGIRSLVSVQGSLAMYAIHAFGSDEQKDQWLPDMASGHRIGCFGLTEPDH 155 Query: 160 GSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPT 219 GSD T A GD W+L GTK WITN A VV+A TD +GI F+VP T Sbjct: 156 GSDPAGMRTRATRSGDDWILTGTKMWITNGSVADVAVVWARTD-----EGIRGFVVPTDT 210 Query: 220 PGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPG-MGFKIAMQTLDMGRIGIASQ 278 PG T + K+ +RAS T+ L+ + R+P L PG ++ L+ R GI Sbjct: 211 PGFTANTIKSKMSLRASVTSELVLDGVRLPDSARL--PGATSLGAPLRCLNEARFGIVFG 268 Query: 279 ALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNK 338 ALG A+ L+ A+ YA +R F P+ Q Q KLADM L LL KD Sbjct: 269 ALGAARDCLETALAYACSREQFDRPIGGFQLTQQKLADMTLEYGKGFLLALHLGRQKDAG 328 Query: 339 KPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQ 398 + ++ ++ KL A I+ A +LG G E P R+ + YEGTSE+ Sbjct: 329 ELAPEQVSLGKLNNVREAIEIARTARTVLGASGITGEYPVMRHANNLESVLTYEGTSEMH 388 Query: 399 RLVIA 403 L+I Sbjct: 389 TLIIG 393 >6CY8-B nrPDB Length = 380 Score = 204 bits (518), Expect = 7e-53, Method: Compositional matrix adjust. Identities = 118/355 (33%), Positives = 193/355 (54%), Gaps = 4/355 (1%) Query: 56 IAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELS--GAGLDYLAYSIALEEISRGCASTG 113 ++A L +++ FP +G+ G + +PE+ + G+G D L +E + + C TG Sbjct: 23 LSAPLQEDNGFPRDNWNALGDFGYFGLPIPEKYAKDGSGFDILTTIKIIEGLGQSCTDTG 82 Query: 114 VIMSVNNSLYLG--PILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAR 171 ++ + + PIL+ GS K Q + G KI A+SE GSD +TTA+ Sbjct: 83 LLFAGAAHTFACSMPILEHGSETLKHQLLPDLATGRKIAANAISEASAGSDISNLATTAQ 142 Query: 172 EEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKL 231 +EGD +VLNG K+++TN A VV+A+T++ G +AF+VP TPG+++G KL Sbjct: 143 KEGDYYVLNGGKSYVTNGSIADYYVVYATTNKKHGYLGQTAFVVPRNTPGISVGNDYHKL 202 Query: 232 GIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAV 291 G+R++ + F++C I K+ LG G G +I ++D R + + +G Q L+ + Sbjct: 203 GLRSAPLNQVFFDNCTIHKDYALGREGQGARIFAASMDWERCCLFAIFVGAMQRDLNQCI 262 Query: 292 KYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLA 351 +YA R +++ Q + ++ADM + LESARL+ + AA K TK AM+KLA Sbjct: 263 EYANTRMQGDKTISRFQAVSHRIADMGVRLESARLMLYYAAWQKSQDVDNTKAVAMSKLA 322 Query: 352 ASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHL 406 SEA +I++ G +GY+ E +DA + ++ GTS+IQR +I L Sbjct: 323 ISEAFVQSGIDSIRVHGALGYLDEGRVNNSIKDALGSVLFSGTSDIQRELICNRL 377 >3P4T-A nrPDB Length = 403 Score = 203 bits (517), Expect = 9e-53, Method: Compositional matrix adjust. Identities = 131/361 (36%), Positives = 186/361 (51%), Gaps = 3/361 (0%) Query: 39 QMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAY 98 + LR+T R FAE+E++P A + ++ P +K ELGLL PE+ G+G D Sbjct: 31 EALRKTVRAFAEREVLPHAHEWERAGEIPRELHRKAAELGLLGAGFPEDAGGSGGDGADP 90 Query: 99 SIALEEISRGCASTGVIMSVNNSLYLGP-ILKFGSSQQKQQWITPFTNGDKIGCFALSEP 157 + EE+ + GV S+ P ++ G + ++ P G+KIG A++EP Sbjct: 91 VVICEEMHYAGSPGGVYASLFTCGIAVPHMIASGDQRLIDTYVRPTLRGEKIGALAITEP 150 Query: 158 GNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPM 217 G GSD G T A +GD +V+NG K +IT+ A V A T G+S +V Sbjct: 151 GGGSDVGHLRTRADLDGDHYVINGAKTYITSGVRADYVVTAARTGGPGAG-GVSLIVVDK 209 Query: 218 PTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIAS 277 TPG + +K DK+G R+S TA L + D R+P NL+G GF R+G+A+ Sbjct: 210 GTPGFEVTRKLDKMGWRSSDTAELSYTDVRVPVANLVGSENTGFAQIAAAFVAERVGLAT 269 Query: 278 QALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLK-D 336 QA AQ LD V++ NR FG PL Q +Q LA MA ++ AR+ T + Sbjct: 270 QAYAGAQRCLDLTVEWCRNRDTFGRPLISRQAVQNTLAGMARRIDVARVYTRHVVERQLA 329 Query: 337 NKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSE 396 + E AK A EA +++QA+Q+ GGMGY+ E ER YRD RI I GT+E Sbjct: 330 GETNLIAEVCFAKNTAVEAGEWVANQAVQLFGGMGYMAESEVERQYRDMRILGIGGGTTE 389 Query: 397 I 397 I Sbjct: 390 I 390 >3GNC-A nrPDB Length = 399 Score = 201 bits (512), Expect = 4e-52, Method: Compositional matrix adjust. Identities = 121/372 (32%), Positives = 195/372 (52%), Gaps = 4/372 (1%) Query: 33 ELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAG 92 +L + +M+R +A+ +L P + + + ++MGE+GLL +PE+ G G Sbjct: 21 QLADDERMVRDAAHAYAQGKLAPRVTEAFRHETTDAAIFREMGEIGLLGPTIPEQYGGPG 80 Query: 93 LDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCF 152 LDY++Y + E+ R + +MSV +SL + PI +FGS QK++++ G+ IGCF Sbjct: 81 LDYVSYGLIAREVERVDSGYRSMMSVQSSLVMVPIFEFGSDAQKEKYLPKLATGEWIGCF 140 Query: 153 ALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISA 212 L+EP +GSD G+ T AR+ + L+G+K WITNS A VV+A D +++ I Sbjct: 141 GLTEPNHGSDPGSMVTRARKVPGGYSLSGSKMWITNSPIADVFVVWAKLDEDGRDE-IRG 199 Query: 213 FLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGM-GFKIAMQTLDMG 271 F++ GL+ K+G+RAS T ++ ++ +P+EN+L P + G + L+ Sbjct: 200 FILEKGCKGLSAPAIHGKVGLRASITGEIVLDEAFVPEENIL--PHVKGLRGPFTCLNSA 257 Query: 272 RIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRA 331 R GIA ALG A++ A +Y +R FG PL Q IQ KLADM + R Sbjct: 258 RYGIAWGALGAAESCWHIARQYVLDRKQFGRPLAANQLIQKKLADMQTEITLGLQGVLRL 317 Query: 332 AMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIY 391 +KD + +++ K + A I+ A +LGG G E R+ + + Y Sbjct: 318 GRMKDEGTAAVEITSIMKRNSCGKALDIARLARDMLGGNGISDEFGVARHLVNLEVVNTY 377 Query: 392 EGTSEIQRLVIA 403 EGT +I L++ Sbjct: 378 EGTHDIHALILG 389 >5AHS-A nrPDB Length = 401 Score = 201 bits (510), Expect = 7e-52, Method: Compositional matrix adjust. Identities = 124/381 (32%), Positives = 195/381 (51%), Gaps = 8/381 (2%) Query: 33 ELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAG 92 EL + L+ R+ A+ A Q D +P V ++ + G + M +P + G G Sbjct: 3 ELTPEQRTLQTQARELAQSVFASTAVQTDLTEQYPWDNVAQLRDAGFMGMMLPTSVGGRG 62 Query: 93 LDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCF 152 L L I +EE+++ CA+ G I +N +G I K+GS +Q + GDK Sbjct: 63 LSTLDTVIVIEEMAKACATMGRITVDSNLGAIGAITKYGSEEQIKLAADLVLAGDK-PAI 121 Query: 153 ALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISA 212 +SEP GS A +T A + GD ++LNG K WIT + ++FA +GI A Sbjct: 122 CISEPNAGSAASEMTTRADKNGDHYILNGEKYWITGGGVSKLHLIFARVFDDGVEQGIGA 181 Query: 213 FLVPMPT---PGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPG---MGFKIAMQ 266 F+ + GL +G++ +G+R +L F D +I K ++ P GF M Sbjct: 182 FITVLDDHGPEGLKVGRRLYAMGVRGIPETHLEFHDLKIHKSMMITFPDGLKRGFAALMS 241 Query: 267 TLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARL 326 + R+G + ALGIAQ + + V Y + R FG PL + Q +Q+ +ADM++ LE+ARL Sbjct: 242 AYNAQRVGAGAVALGIAQCAFEEGVAYLKRREQFGRPLAEFQGLQWMVADMSVQLEAARL 301 Query: 327 LTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDAR 386 + R+A + P ++A AK+ A+E A +++ A+Q G GY P ER+ RDAR Sbjct: 302 M-LRSAAVSGETFPDINKAAQAKIFAAETANKVTNDALQFFGSSGYGRHNPMERHVRDAR 360 Query: 387 ITEIYEGTSEIQRLVIAGHLL 407 + I GT++I R +A +L Sbjct: 361 MFTIAGGTAQILRTQVASKIL 381 >1SIR-A nrPDB Length = 394 Score = 177 bits (448), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 121/386 (31%), Positives = 191/386 (49%), Gaps = 12/386 (3%) Query: 21 DWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLL 80 DW+ + + + E ++R T R + ++ L+P ++ +F + +MGELG+L Sbjct: 5 DWQDPLVLEEQLTTDEI--LIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGVL 62 Query: 81 AMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWI 140 + + AG+ +AY + E+ R + MSV +SL + PI +GS +Q+Q+++ Sbjct: 63 GPTI-KGYGCAGVSSVAYGLLARELERVDSGYRSAMSVQSSLVMHPIYAYGSEEQRQKYL 121 Query: 141 TPFTNGDKIGCFALSEPGNGSDAGAASTTAR--EEGDSWVLNGTKAWITNSWEASATVVF 198 G+ +GCF L+EP +GSD + T A S+ LNGTK WITNS A VV+ Sbjct: 122 PQLAKGELLGCFGLTEPNSGSDPSSMETRAHYNSSNKSYTLNGTKTWITNSPMADLFVVW 181 Query: 199 ASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLL-GEP 257 A ++ I FL+ GL+ + + K +RAS+T +I + +P+EN+L G Sbjct: 182 ARC----EDGCIRGFLLEKGMRGLSAPRIQGKFSLRASATGMIIMDGVEVPEENVLPGAS 237 Query: 258 GMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADM 317 +G L+ R GIA LG ++ L A +YA +R FG PL + Q IQ KLADM Sbjct: 238 SLGGPFG--CLNNARYGIAWGVLGASEFCLHTARQYALDRMQFGVPLARNQLIQKKLADM 295 Query: 318 ALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMP 377 + + LKD K + ++ K A I+ QA +LGG G E Sbjct: 296 LTEITLGLHACLQLGRLKDQDKAAPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEYH 355 Query: 378 AERYYRDARITEIYEGTSEIQRLVIA 403 R+ + YEGT +I L++ Sbjct: 356 VIRHAMNLEAVNTYEGTHDIHALILG 381 >2IX5-A nrPDB Length = 436 Score = 168 bits (425), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 112/374 (29%), Positives = 185/374 (49%), Gaps = 8/374 (2%) Query: 29 YQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEEL 88 + + PE Q +R+ R+ EKE+ PI + ++ FP K+G +G+ + + Sbjct: 51 FNDLLTPE-EQAIRKKVRECMEKEVAPIMTEYWEKAEFPFHITPKLGAMGVAGGSI-KGY 108 Query: 89 SGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDK 148 GL A +IA EI+R AS + V++SL + I GS QK++++ + Sbjct: 109 GCPGLSITANAIATAEIARVDASCSTFILVHSSLGMLTIALCGSEAQKEKYLPSLAQLNT 168 Query: 149 IGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNK 208 + C+AL+EP NGSDA TTA + W +NG K WI NS A ++FA + Q Sbjct: 169 VACWALTEPDNGSDASGLGTTATKVEGGWKINGQKRWIGNSTFADLLIIFARNTTTNQ-- 226 Query: 209 GISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMG-FKIAMQT 267 I+ F+V PGL K +K+G+R +++ ++ +P E+ L PG+ F+ + Sbjct: 227 -INGFIVKKDAPGLKATKIPNKIGLRMVQNGDILLQNVFVPDEDRL--PGVNSFQDTSKV 283 Query: 268 LDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLL 327 L + R+ +A Q +GI+ D +Y + R FGAPL Q Q KL M +++ L+ Sbjct: 284 LAVSRVMVAWQPIGISMGIYDMCHRYLKERKQFGAPLAAFQLNQQKLVQMLGNVQAMFLM 343 Query: 328 TWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARI 387 WR L + + ++++ K S A + ++LGG G + + + + D Sbjct: 344 GWRLCKLYETGQMTPGQASLGKAWISSKARETASLGRELLGGNGILADFLVAKAFCDLEP 403 Query: 388 TEIYEGTSEIQRLV 401 YEGT +I LV Sbjct: 404 IYTYEGTYDINTLV 417 >4W9U-A nrPDB Length = 395 Score = 162 bits (410), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 112/375 (29%), Positives = 184/375 (49%), Gaps = 11/375 (2%) Query: 33 ELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQ---VKKMGELGLLAMDVPEELS 89 +L E +M+R + + FA L+P +++K +L T+ MG+ GLL + +PE+ Sbjct: 18 QLTEDERMIRDSAKAFASDVLLP---RVEKAYLEETTDPELFHLMGQAGLLGVTLPEDYG 74 Query: 90 GAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKI 149 A Y+AY + E+ R + +MSV +SL + PI +GS +Q+++++ +G+ I Sbjct: 75 AANASYVAYGLVAREVERIDSGYRSMMSVQSSLVMYPIYAYGSDEQRKKYLPGLVSGELI 134 Query: 150 GCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKG 209 GCF L+EP GSD T A + + L+G+K WI+NS A VV+A + + + Sbjct: 135 GCFGLTEPDAGSDPAGMKTRAEKIDGGYRLSGSKMWISNSPIADVFVVWAKS--AAHDNA 192 Query: 210 ISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGM-GFKIAMQTL 268 I F++ GL+ K KL +RAS T ++ + + ++ +L P + G K L Sbjct: 193 IRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVEVSEDAIL--PNVSGLKGPFGCL 250 Query: 269 DMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLT 328 + R GI+ LG A+ A +Y +R F PL Q Q KLADM + + Sbjct: 251 NRARYGISWGVLGAAEDCWFRARQYGLDRKQFNKPLAGTQLYQKKLADMQTEIALGIQAS 310 Query: 329 WRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARIT 388 R L D K + ++ K A I+ QA + GG G E R+ ++ Sbjct: 311 LRVGRLFDEGKMAPEMISIVKRNNCGKALDIARQARDMHGGNGIQIEYHVMRHAQNLETV 370 Query: 389 EIYEGTSEIQRLVIA 403 YEGT ++ L++ Sbjct: 371 NTYEGTHDVHALILG 385 >4HR3-A nrPDB Length = 415 Score = 145 bits (366), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 107/342 (31%), Positives = 166/342 (48%), Gaps = 9/342 (2%) Query: 78 GLLAMDVPEELSGAGLDYLAYSIALEEISRGC-ASTGVIMSVNNSLYLGPILKFGSSQQK 136 GL + +P+ G GL Y+ E++ R A T + +S + + ++GS +QK Sbjct: 71 GLWNLFLPDPELGGGLSNSEYAPLAEQMGRSLFAPTVFNCNAPDSGNMEVLHRYGSQEQK 130 Query: 137 QQWITPFTNGDKIGCFALSEPG-NGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASAT 195 + W+ P GD F ++EP SDA + TA EGD V+NG K W T Sbjct: 131 EVWLEPLLEGDIRSAFCMTEPDVASSDATNMAATAVVEGDEVVINGRKWWSTGVGHPDCK 190 Query: 196 VVF--ASTD-RSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLI--FEDCRIPK 250 V+ TD + + S LVPM TPG+T+ + +G + + F++ R+P Sbjct: 191 VIIFMGLTDPNAHRYARHSMVLVPMDTPGITVERMLPTMGFYDEPGGHGVVSFDNVRLPA 250 Query: 251 ENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNI 310 + + PG GF+IA L GR+ A + +G+A+ +L+ A + +R AFG PL L Sbjct: 251 DAFIAGPGKGFEIAQGRLGPGRVHHAMRLIGLAEVALEHACRRGLDRTAFGKPLVNLGGN 310 Query: 311 QFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMA--KLAASEAATAISHQAIQILG 368 + ++AD +A+ RLL AA L D SA++ K+AA A + AIQI G Sbjct: 311 RERIADARIAINQTRLLVLHAAWLLDTVGIMGALSAVSEIKVAAPNMAQQVIDMAIQIHG 370 Query: 369 GMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRSY 410 G G + P + +AR + +G E+ R V+A L Y Sbjct: 371 GGGLSNDFPLAAAWVNARALRLADGPDEVHRGVVARIELAKY 412 >5ZW7-A nrPDB Length = 402 Score = 144 bits (363), Expect = 8e-35, Method: Compositional matrix adjust. Identities = 98/346 (28%), Positives = 167/346 (48%), Gaps = 2/346 (0%) Query: 63 EHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSL 122 + + T KK G V + G+ L L ++ +E + +G G+ S+ L Sbjct: 34 QKILSTELWKKAAAYGFAHGPVSHQFGGSELGALDTALMIEALGKGSRDIGLSFSLCAHL 93 Query: 123 Y--LGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLN 180 + P+ +FGSS+ K +++ G I A +EP GSD TA+ ++LN Sbjct: 94 CACVIPLYRFGSSELKDKYLESLVTGKLIAANAATEPDAGSDIYNMQATAQPCEGGYILN 153 Query: 181 GTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTAN 240 G K +ITN+ A +++A T+ G+SAFL+ TPGL +G+ K + + Sbjct: 154 GKKIFITNAPIADVFIIYAKTNPDHGFLGVSAFLIEKGTPGLNVGEVIPKDCLSNCPWSE 213 Query: 241 LIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAF 300 ++F D IP+ +G G G I ++ + +++ +G L+ ++YA+ R F Sbjct: 214 IVFNDIFIPQSQRIGMEGAGGAIFHDSMIWEKGCLSALFVGGLARLLETTLEYAKARQQF 273 Query: 301 GAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAIS 360 G + + Q++ ++ DM L LE RL+ +RA D + + AM+KL SE A Sbjct: 274 GKAIGQFQSVSNRIIDMKLRLEQCRLMLYRACWKHDQGQDAEADIAMSKLLISEYAVQSG 333 Query: 361 HQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHL 406 AIQ GG E+ R+ + + I+ GT++IQ+ +IA L Sbjct: 334 LDAIQTFGGAAMDQELGLVRHLLNMIPSRIFSGTNDIQKEIIARKL 379 >4RM7-A nrPDB Length = 391 Score = 134 bits (337), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 112/384 (29%), Positives = 182/384 (47%), Gaps = 10/384 (2%) Query: 34 LPETHQMLRQTCRDFAEKELVPIA-AQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAG 92 L Q L R++ EK P + ++ K+ P VK +L V + Sbjct: 8 LSRDEQRLLNHVREYGEKYFTPASISKWRKDQGLPDEVVKAFVDLDFNGFGVIHRRNHRT 67 Query: 93 LDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILK-FGSSQQKQQWITPFTNGDKIG- 150 D A + +EE+SR +G + N L IL+ F SS Q + T + + ++ Sbjct: 68 YDLFAQVLVIEELSR---ISGACLPFQNDLLQLQILEAFASSAQTSPFRTEYQDTGRLSY 124 Query: 151 CFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQN--K 208 A+SEP GSD + T EGD+ V+NGTK ++ N A A +V ++ D++ + Sbjct: 125 ALAISEPEAGSDTRSMRTHVTREGDTLVMNGTKMFVNNGEYAPALLV-SAYDKTGDDGEP 183 Query: 209 GISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTL 268 S ++VP G+ E K+G A + F++ + + L GF L Sbjct: 184 EFSFWMVPRSAAGI-YAYPEQKIGQSMLPFATVRFDNVEVKESWRLKGSSKGFSQLYSLL 242 Query: 269 DMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLT 328 + GR+ + ALG AQA+++ AV +A R AFG + LQ +Q KL +M + L + R L Sbjct: 243 EYGRVFTCAAALGEAQAAMEDAVAWARGREAFGQRIADLQQVQMKLTEMEVKLTNMRNLV 302 Query: 329 WRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARIT 388 + AA D + A+ K +AAT ++ A+QILGG GY+ E ++D R Sbjct: 303 YGAAREYDRGEHKRLSVALMKYYVPKAATEVASDAMQILGGRGYIQENRVSSIWQDCRGY 362 Query: 389 EIYEGTSEIQRLVIAGHLLRSYRS 412 + +GT E+ ++ A +L Y++ Sbjct: 363 QFADGTDEVMVVIAAPLILEQYKA 386 >2WBI-A nrPDB Length = 428 Score = 129 bits (324), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 101/352 (28%), Positives = 167/352 (47%), Gaps = 17/352 (4%) Query: 70 QVKKMGEL-GLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVI-MSVNNSLYLGPI 127 ++K+M ++ GL + +P + +GL ++ Y++ EE + + V ++ + + Sbjct: 71 KLKEMAKVEGLWNLFLP---AVSGLSHVDYALIAEETGKCFFAPDVFNCQAPDTGNMEVL 127 Query: 128 LKFGSSQQKQQWITPFTNGDKIGCFALSEPG-NGSDAGAASTTAREEGDSWVLNGTKAWI 186 +GS +QK+QW+ P G+ CF ++EP SDA + + + DS+V+NG K W Sbjct: 128 HLYGSEEQKKQWLEPLLQGNITSCFCMTEPDVASSDATNIECSIQRDEDSYVINGKKWWS 187 Query: 187 TNSWEASATVVFA-----STDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTA-- 239 + + + +T SR +K S LVPM TPG+ + + G + Sbjct: 188 SGAGNPKCKIAIVLGRTQNTSLSR-HKQHSMILVPMNTPGVKIIRPLSVFGYTDNFHGGH 246 Query: 240 -NLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRH 298 + F R+P NL+ G GF+I+ L GRI + +G+A+ +L + A R Sbjct: 247 FEIHFNQVRVPATNLILGEGRGFEISQGRLGPGRIHHCMRTVGLAERALQIMCERATQRI 306 Query: 299 AFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDN--KKPFTKESAMAKLAASEAA 356 AF L + + +A+ +A+E RLLT +AA D KE AM K+AA A Sbjct: 307 AFKKKLYAHEVVAHWIAESRIAIEKIRLLTLKAAHSMDTLGSAGAKKEIAMIKVAAPRAV 366 Query: 357 TAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLR 408 + I AIQ+ GG G + P Y R+ + +G E+ IA LR Sbjct: 367 SKIVDWAIQVCGGAGVSQDYPLANMYAITRVLRLADGPDEVHLSAIATMELR 418 >1R2J-A nrPDB Length = 366 Score = 124 bits (310), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 101/353 (28%), Positives = 166/353 (47%), Gaps = 8/353 (2%) Query: 57 AAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIM 116 AA+ D P + ++G GLL +V E G GL + C+S +M Sbjct: 16 AAEWDTSGELPRDLLVRLGADGLLCAEVAAEHGGLGLGSRENGEFTAHVGSLCSSLRSVM 75 Query: 117 SVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDS 176 + + + + + G + Q+ ++ T+G K+ SE GSD A T R +GD+ Sbjct: 76 T-SQGMAAWTVQRLGDAGQRATFLKELTSG-KLAAVGFSERQAGSDLSAMRTRVRLDGDT 133 Query: 177 WVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRAS 236 V++G K W T + A VVF +++ + +VP TPG+ + + G RA+ Sbjct: 134 AVVDGHKVWTTAAAYADHLVVFGL----QEDGSGAVVVVPADTPGVRVERVPKPSGCRAA 189 Query: 237 STANLIFEDCRIPKENLLGEPGMGFKIAMQ-TLDMGRIGIASQALGIAQASLDCAVKYAE 295 A+L + R+P +L G + + +L GR +A +GI +A AV +A Sbjct: 190 GHADLHLDQVRVPAGAVLAGSGASLPMLVAASLAYGRKSVAWGCVGILRACRTAAVAHAR 249 Query: 296 NRHAFGAPLTKLQNIQFKLADMALALE-SARLLTWRAAMLKDNKKPFTKESAMAKLAASE 354 R FG PL Q + +AD+ A + +AR+ + + + + +AK A+E Sbjct: 250 TREQFGRPLGDHQLVAGHIADLWTAEQIAARVCEYASDHWDEGSPEMVPATILAKHVAAE 309 Query: 355 AATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLL 407 A A + A Q+L G ER YRDA++ EI EG+SE+ R+++A H L Sbjct: 310 RAAAGAATAAQVLASAGAREGHVVERAYRDAKLMEIIEGSSEMCRVMLAQHAL 362 >5EZ3-A nrPDB Length = 573 Score = 103 bits (257), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 80/271 (29%), Positives = 134/271 (49%), Gaps = 22/271 (8%) Query: 152 FALSEPGNGSDAGAASTTAREE-GDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGI 210 ++E G+D A +T A G +W L G K W ++ + A + A T +G+ Sbjct: 211 MGMTEKQGGTDVRANATRAEPAIGGAWRLTGHK-WFMSAPMSDAFLTLAQT-----KEGL 264 Query: 211 SAFLVPM-----PTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAM 265 S FL+P + G + +DKLG R+++++ + F+ ++G PG G K M Sbjct: 265 SCFLLPRLGEKGESNGFFFQRLKDKLGNRSNASSEVEFDGA---LGQMIGSPGEGVKTIM 321 Query: 266 QTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESAR 325 + + R+ A + G+ ++ L AV ++ +RH FG PL + +Q LADMAL + A Sbjct: 322 DMVTLTRLDCAVASAGLMRSGLAEAVHHSRHRHVFGKPLVEQPLMQRVLADMALDVAGAT 381 Query: 326 LLTWRAAMLKDNKKPFTKESAMA-------KLAASEAATAISHQAIQILGGMGYVTEMPA 378 L+ R A D E+A A K + A A+ ++A++ LGG GY+ + Sbjct: 382 ALSMRLARAFDMAASDRAEAAFARSMTPVVKYWVCKIAPALLYEAMECLGGNGYIEDGNL 441 Query: 379 ERYYRDARITEIYEGTSEIQRLVIAGHLLRS 409 R YR+A + I+EG+ + L +A L R+ Sbjct: 442 ARAYREAPVNAIWEGSGNVMALDVARVLSRA 472 >4X28-A nrPDB Length = 400 Score = 102 bits (254), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 92/349 (26%), Positives = 157/349 (44%), Gaps = 26/349 (7%) Query: 71 VKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGP-ILK 129 + +MG G LA+ P+E G G + I +E + A +++N+ + P I+ Sbjct: 49 IAQMGRDGWLALGWPKEYGGQGRSAMDQLIFTDEAAIAGAPV-PFLTINS---VAPTIMA 104 Query: 130 FGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNS 189 +G+ +QK+ ++ GD SEPG G+D TTA +GD +V+NG K W + Sbjct: 105 YGTDEQKRFFLPRIAAGDLHFSIGYSEPGAGTDLANLRTTAVRDGDDYVVNGQKMWTSLI 164 Query: 190 WEASATVVFASTDR----SRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFED 245 A + T+ +++++GIS +VP G + G S+T + D Sbjct: 165 QYADYVWLAVRTNPESSGAKKHRGISVLIVPTTAEGFSWTPVHTMAGPDTSAT---YYSD 221 Query: 246 CRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAEN-RHAFGAPL 304 R+P N +GE G+K+ L+ R+ + S A L ++A+N + A G L Sbjct: 222 VRVPVANRVGEENAGWKLVTNQLNHERVALVSPAPIF--GCLREVREWAQNTKDAGGTRL 279 Query: 305 TKLQNIQFKLADMALALESARLLTWRAAMLKDNKK---PFTKESAMAKLAASEAATAISH 361 + +Q LA + E +L+ W A + K P +++ AK+ +E AT Sbjct: 280 IDSEWVQLNLARVHAKAEVLKLINWELASSQSGPKDAGPSPADASAAKVFGTELATEAYR 339 Query: 362 QAIQILG--------GMGYVTEMPAERYYRDARITEIYEGTSEIQRLVI 402 +++LG G + ER +R I GT+E+QR +I Sbjct: 340 LLMEVLGTAATLRQNSPGALLRGRVERMHRACLILTFGGGTNEVQRDII 388 >3M9V-A nrPDB Length = 439 Score = 101 bits (251), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 94/346 (27%), Positives = 159/346 (45%), Gaps = 26/346 (7%) Query: 57 AAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYL---AYSIALEEISRGCASTG 113 AA+ D++ FPT + + GL+ VP EL G G+D L A ++ + + Sbjct: 42 AAEHDRDGTFPTDTFDALRKDGLMGATVPAELGGLGVDRLYDVAVALLAVARADASTALA 101 Query: 114 VIMSVNNSLYLGPILKFGSSQQK---QQWITPFTNGDKIGCFALSEPGNGSDAGAASTTA 170 + M ++ L LG + G + + ++ + GD + C + D A TT Sbjct: 102 LHMQLSRGLTLGYEWRHGDERARTLAERILRGMVAGDAVVCSGIK------DHHTAVTTL 155 Query: 171 REEG-DSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKED 229 R +G W+L+G K ++ + + V+ A TD + +++ +V TPG T+ D Sbjct: 156 RPDGAGGWLLSGRKTLVSMAPVGTHFVINARTDGTDGPPRLASPVVTRDTPGFTVLDNWD 215 Query: 230 KLGIRASSTANLIFEDCRIPKENLLGEPGMGFK----IAMQTLDMGRIGIASQALGIAQA 285 LG+RAS T +++F+DC IP +++L +G + +A QT+ + + +G+AQA Sbjct: 216 GLGMRASGTVDIVFDDCPIPADHVLMRDPVGARNDAVLAGQTV--SSVSVLGVYVGVAQA 273 Query: 286 SLDCAVKYAENR--HAFGAPLTKLQNIQFKL----ADMALALESARLLTWRAAMLKDNK- 338 + D AV E R A LT + I +L A AL +A L+ + D + Sbjct: 274 AYDTAVAALERRPEPPQAAALTLVAEIDSRLYALRATAGSALTAADALSADLSGDMDERG 333 Query: 339 KPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRD 384 + + AKLA + A I + ++GG Y P R RD Sbjct: 334 RQMMRHFQCAKLAVNRLAPEIVSDCLSLVGGASYTAGHPLARLLRD 379 >3U33-A nrPDB Length = 541 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 85/292 (29%), Positives = 134/292 (45%), Gaps = 36/292 (12%) Query: 137 QQWITPFTN----------GDKIGCF---ALSEPGNGSDAGAASTTA-REEGDSWVLNGT 182 Q W TP + G K G ++E GSD + +T A R E S+ L G Sbjct: 154 QDWTTPLLSDRYDSHLLPGGQKRGLLIGMGMTEKQGGSDVMSNTTRAERLEDGSYRLVGH 213 Query: 183 KAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTP-----GLTLGKKEDKLGIRASS 237 K W + ++ A +V A T G+S F VP P + L + +DKLG R+++ Sbjct: 214 K-WFFSVPQSDAHLVLAQT-----AGGLSCFFVPRFLPDGQRNAIRLERLKDKLGNRSNA 267 Query: 238 TANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENR 297 + + F+D LLG G G ++ ++ M R A + + + + A+ +A R Sbjct: 268 SCEVEFQDA---IGWLLGLEGEGIRLILKMGGMTRFDCALGSHAMMRRAFSLAIYHAHQR 324 Query: 298 HAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAAT 357 H FG PL + ++ L+ MAL LE L +R A D ++ KE+ A+L A Sbjct: 325 HVFGNPLIQQPLMRHVLSRMALQLEGQTALLFRLARAWD-RRADAKEALWARLFTPAAKF 383 Query: 358 AISH-------QAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVI 402 I +A+++LGG+GY E R YR+ + I+EG+ I L + Sbjct: 384 VICKRGMPFVAEAMEVLGGIGYCEESELPRLYREMPVNSIWEGSGNIMCLDV 435 >3MKH-A nrPDB Length = 438 Score = 95.5 bits (236), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 94/359 (26%), Positives = 150/359 (41%), Gaps = 59/359 (16%) Query: 78 GLLAMDVPEELSGAGLDYLAYSIALEEISRGCAS---TGVIMSVNNSLYLGPILKFGSSQ 134 G+L + G G + +I +EE C S + + L L PI + Sbjct: 58 GILKGQISPAHGGTGGTLIESAILVEE----CYSVEPSAALTIFATGLGLTPI-NLAAGP 112 Query: 135 QKQQWITPFTNGD--KIGCFALSEPG---NGSDAGAAS--TTAREEGDSWVLNGTKAWIT 187 Q +++ PF +G+ + SEPG N + GA TTAR EGD WV+NG K W T Sbjct: 113 QHAEFLAPFLSGEGSPLASLVFSEPGGVANALEKGAPGFQTTARLEGDEWVINGEKMWAT 172 Query: 188 NS--WEASAT--------------------------VVFASTDRSRQNKGISAFLVPMPT 219 N W+ ++ D R +G L + T Sbjct: 173 NCAGWDFKGCDLACVVCRDATTPLEEGQDPENKVMIILVTRADLDRNGEGSFEVLRHVAT 232 Query: 220 PGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQA 279 PG T + S ++ + + R+P +N+L G G K+A D + + + Sbjct: 233 PGHT-----------SVSGPHVRYTNVRVPTKNVLCPAGQGAKVAFGAFDGSAVLVGAMG 281 Query: 280 LGIAQASLDCAVKYAENRHAFGA-PLTKLQNIQFKLADMALALESARLLTWRAAMLKDN- 337 +G+ +A+ D A+K+A+ + GA PL + Q L+ + + E+AR LTW+AA +N Sbjct: 282 VGLMRAAFDAALKFAKEDNRGGAVPLLERQAFADLLSGVKIQTEAARALTWKAAHAMENG 341 Query: 338 --KKPFTKESAM-AKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEG 393 +E A+ AK+ SEAA I +G Y + P A + I++G Sbjct: 342 PGDYDARRELALAAKVFCSEAAVKACTDVINAVGISAYDLQRPFSDLLNTAVVLPIFDG 400 >4X28-D nrPDB Length = 373 Score = 92.0 bits (227), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 92/354 (25%), Positives = 150/354 (42%), Gaps = 32/354 (9%) Query: 59 QLDK-EHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMS 117 +LDK E F +K+ + G+L+ PE L G G L L + A+ + S Sbjct: 31 ELDKLEQRFDRELWRKLIDAGILSSAAPESLGGDGFGVLEQVAVLVALGHQLAAVPYLES 90 Query: 118 VNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSW 177 V L G + +FGS + +Q W +GD+I AL + G A G + Sbjct: 91 V--VLAAGALARFGSPELQQGWGVSAVSGDRILTVALD-----GEMGEGPVQAAGTGHGY 143 Query: 178 VLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTL-GKKEDKLGIRAS 236 L GT+ + A A +V A TD G + FLV PG+ + LG Sbjct: 144 RLTGTRTQVGYGPVADAFLVPAETD-----SGAAVFLVAAGDPGVAVTALATTGLG---- 194 Query: 237 STANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAEN 296 S +L ++ +G G +A+ + + + LG+ + L +YA Sbjct: 195 SVGHLELNGAKVDAARRVG----GTDVAVWLGTLSTLSRTAFQLGVLERGLQMTAEYART 250 Query: 297 RHAFGAPLTKLQNIQFKLADMALALESARLL----TWRAA----MLKDNKKPFTKESAMA 348 R F P+ Q + +LAD + ++ RL WR A ++ +P + A A Sbjct: 251 REQFDRPIGSFQAVGQRLADGYIDVKGLRLTLTQAAWRVAEDSLASRECPQPADIDVATA 310 Query: 349 KLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEG--TSEIQRL 400 A+EA ++H + + GG+G T+ P RY+ A+ TE G T +++R+ Sbjct: 311 GFWAAEAGHRVAHTIVHVHGGVGVDTDHPVHRYFLAAKQTEFALGGATGQLRRI 364 >4ZYJ-A nrPDB Length = 425 Score = 91.7 bits (226), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 90/360 (25%), Positives = 156/360 (43%), Gaps = 29/360 (8%) Query: 47 DFAEKELVPIAAQL---DKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALE 103 D E+ L + A+ D+E P +M + G+L VPE+L G G+ L + +AL Sbjct: 51 DLLERYLPALEAESRDNDREATLPVHLFDRMRKEGVLGATVPEDLGGLGVHSL-HDVALA 109 Query: 104 EISRGCASTGVIMSVNNSLYLGPILKF----GSSQQK---QQWITPFTNGDKIGCFALSE 156 GV ++++ G L F G+ + + + G+ + C A+ Sbjct: 110 LARIAGRDAGVALALHMQFSRGLTLDFEWRHGAPSTRPLAEDLLRQMGAGEAVICGAVK- 168 Query: 157 PGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVP 216 D + R S+ LNG K ++ + A+ VV + + ++A +V Sbjct: 169 -----DVRGTTVLTRATDGSYRLNGRKTLVSMAGIATHYVVSTRLEEAGAPVRLAAPVVA 223 Query: 217 MPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLL--GEPGMGFKIAMQTLDMGRIG 274 TPGLT+ D +G+R+S + +++F+ C + ++ +L GEPG+ A+ + I Sbjct: 224 RTTPGLTVLDNWDGMGMRSSGSVDIVFDGCPVDRDRVLPRGEPGVRDDAALAGQTVSSIA 283 Query: 275 IASQALGIAQASLDCAVKYAENRHAFGAPL---TKLQNIQFKLADMALALESA-----RL 326 + +GIA+A+ A+ E R GAP T + I +L + A+ SA RL Sbjct: 284 MLGIYVGIAEAARRIALT--ELRRRGGAPAGVRTTVAEIDARLFALHTAVASALTTADRL 341 Query: 327 LTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDAR 386 + L + AKL + + + + ++GG GY P R YRD R Sbjct: 342 ADDLSGDLAARGRAMMTPFQYAKLLVNRHSVGVVDDCLMLVGGAGYSNSHPLARLYRDVR 401 >3MXL-A nrPDB Length = 395 Score = 88.2 bits (217), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 103/355 (29%), Positives = 154/355 (43%), Gaps = 40/355 (11%) Query: 57 AAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIA--LEEISRGCASTGV 114 AA D+ FP ++ +LGL+ VP EL G GL L Y +A L ++ AST + Sbjct: 31 AADRDRTGTFPVEAFEQFAKLGLMGATVPAELGGLGLTRL-YDVATALMRLAEADASTAL 89 Query: 115 IMSVNNS--LYLGPILKFGSSQQK---QQWITPFTNGDKIGCFALSEPGNGSDAGAASTT 169 V S L L + G+ + ++ + G+ C AL DA T Sbjct: 90 AWHVQLSRGLTLTYEWQHGTPPVRAMAERLLRAMAEGEAAVCGALK------DAPGVVTE 143 Query: 170 AREEG-DSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPM---PTPGLTLG 225 +G W+L+G K + S AT F R R + G VP+ PGLT+ Sbjct: 144 LHSDGAGGWLLSGRKVLV--SMAPIATHFFVHAQR-RDDDGSVFLAVPVVHRDAPGLTVL 200 Query: 226 KKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFK----IAMQTL-DMGRIGIASQAL 280 D LG+RAS T ++F+ C + + LL +G + +A QT+ + +GI + Sbjct: 201 DNWDGLGMRASGTLEVVFDRCPVRADELLERGPVGARRDAVLAGQTVSSITMLGIYA--- 257 Query: 281 GIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALES---ARLLTWRAAMLKDN 337 GIAQA+ D AV + R G P + + L AL + A L AA + + Sbjct: 258 GIAQAARDIAVGFCAGRG--GEPRAGARALVAGLDTRLYALRTTVGAALTNADAASVDLS 315 Query: 338 KKPFTKESAM------AKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDAR 386 P + M AK+ +E A A+ + ++GG+ Y P R YRD R Sbjct: 316 GDPDERGRRMMTPFQYAKMTVNELAPAVVDDCLSLVGGLAYTAGHPLSRLYRDVR 370 >2C12-A nrPDB Length = 439 Score = 85.1 bits (209), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 87/349 (24%), Positives = 160/349 (45%), Gaps = 34/349 (9%) Query: 78 GLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQ 137 GL+ VP L G + SI LEE+ +T + + V +L L P++ S ++ Sbjct: 56 GLIKAQVPIPLGGTMESLVHESIILEELFAVEPATSITI-VATALGLMPVILCDSPSLQE 114 Query: 138 QWITPFTNGD--KIGCFALSEPGNGSD-----AGAASTTAREEGDSWVLNGTKAWITNS- 189 +++ PF +G+ + SEP ++ TTAR+ G+ WV++G K W +NS Sbjct: 115 KFLKPFISGEGEPLASLMHSEPNGTANWLQKGGPGLQTTARKVGNEWVISGEKLWPSNSG 174 Query: 190 -W-----EASATVVFASTDRSR-QNKGI---SAFLVPMPTPGLTLGKKEDKLGIR----- 234 W + + V S D S+ Q+ + + V + T K+D I Sbjct: 175 GWDYKGADLACVVCRVSDDPSKPQDPNVDPATQIAVLLVTRETIANNKKDAYQILGEPEL 234 Query: 235 ----ASSTANLIFEDCRIPKENLLGEPGMGFKIAMQT-LDMGRIGIASQALGIAQASLDC 289 +S + F + +P ENLL PG+ + ++T M + + A+G A+A+ + Sbjct: 235 AGHITTSGPHTRFTEFHVPHENLLCTPGLKAQGLVETAFAMSAALVGAMAIGTARAAFEE 294 Query: 290 AVKYAENRHAFGAP-LTKLQNIQFKLADMALALESARLLTWRAA-MLKDNKKPFTKESAM 347 A+ +A++ G+ + + Q++ KL D + LE++RLL W+A L+D + + M Sbjct: 295 ALVFAKSDTRGGSKHIIEHQSVADKLIDCKIRLETSRLLVWKAVTTLEDEALEWKVKLEM 354 Query: 348 A---KLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEG 393 A K+ ++ A A++ +G Y +M R + +++G Sbjct: 355 AMQTKIYTTDVAVECVIDAMKAVGMKSYAKDMSFPRLLNEVMCYPLFDG 403 >5GJ7-A nrPDB Length = 398 Score = 82.0 bits (201), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 95/375 (25%), Positives = 165/375 (44%), Gaps = 21/375 (5%) Query: 25 LHTVYQSVELP-ETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMD 83 ++ +Y LP + + LR T RD A+ A + D+ FP ++ + G + Sbjct: 4 MYDIYGEAALPADVRERLRIT-RDLAQA-FHERAPEHDRAGDFPFENIEDLKASGYVRWT 61 Query: 84 VPEELSGAGLDYLAYSIALEEISRGCASTGVIM--SVNNSLYLGPILKFGSSQQKQQWIT 141 VP E G GL + E +++G ST + + V L+L F + + Sbjct: 62 VPVEYGGLGLSLEEMLMHQEVLAKGDGSTALAIGWHVGILLHLRETGAFPDELFRMVCES 121 Query: 142 PFTNGDKIGCFALSEPGNGSDA--GAASTTAREEGDSWVLNGTKAWITNSWEASATVVFA 199 G I A +EP GS + G TTA + + + G K + T S + +V A Sbjct: 122 VVKEGALINSCA-TEPATGSPSRGGKPETTAVKVPGGYRITGRKTFSTLSPALTWIMVTA 180 Query: 200 STDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGM 259 + + FLV + + + D LG+RA+ + +++ +D +P+E ++ Sbjct: 181 TV---ADEDVVGQFLVR--KEDVEIVETWDTLGMRATGSHDIVLKDVFVPEERVIVIQRP 235 Query: 260 GFKIAMQTLDMG-RIGIASQALGIAQASLDCAVKYAENR--HAFGAPLTKLQNIQFKLAD 316 G + + G + I + LGIA A+ D A++YA + P+ ++ +++ KL + Sbjct: 236 GVQAERRPDGSGWLLHIPACYLGIALAARDFALEYAATYRPNTLPHPIAEVPHVEQKLGE 295 Query: 317 MALALESARLLTWRAAMLKDNKKP-----FTKESAMAKLAASEAATAISHQAIQILGGMG 371 M L L +AR L + A D P + K A+ AA + A++++GG Sbjct: 296 MELKLLAARTLLYDLARRFDAASPEERVKLQPQFGAVKTLATNAANQVVDLAMRVVGGRS 355 Query: 372 YVTEMPAERYYRDAR 386 +P ERYYRD R Sbjct: 356 LSRALPLERYYRDVR 370 >5Y9D-A nrPDB Length = 709 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 59/219 (26%), Positives = 104/219 (47%), Gaps = 28/219 (12%) Query: 111 STGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDK--IGCFALSEPGNGSDAGAAST 168 ST +S++N+L++G I G+ +Q + W+ K GCFA++E G+GS+ T Sbjct: 123 STRTRLSIHNNLFIGSIRGSGTPEQFKYWVKKGAVAVKQFYGCFAMTELGHGSNLKGLET 182 Query: 169 TA--REEGDSWVLN-----GTKAWITNSWEASA-TVVFASTDRSRQNKGISAFLVPMPT- 219 TA ++ D +++N TK WI + S V FA ++ G F+VP+ Sbjct: 183 TATYDQDSDQFIINTPHIGATKWWIGGAAHTSTHCVCFAKLIVHGKDYGTRNFVVPLRNV 242 Query: 220 ------PGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLL------GEPGMGFKIAMQT 267 G+++G K+G + F + RIP++N+L + G+ K A+ Sbjct: 243 HDHSLKVGVSIGDIGKKMGRDGVDNGWIQFTNVRIPRQNMLMRYAKVSDTGVVTKPALDQ 302 Query: 268 LDM-----GRIGIASQALGIAQASLDCAVKYAENRHAFG 301 L GR+ + + + +++ L A++YA R FG Sbjct: 303 LTYGALIRGRVSMIADSFHVSKRFLTIALRYACVRRQFG 341 >5YS9-A nrPDB Length = 708 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 60/229 (26%), Positives = 105/229 (45%), Gaps = 34/229 (14%) Query: 112 TGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDK--IGCFALSEPGNGSDAGAASTT 169 T + + V+ L++G I G+ +Q W+ K GCFA++E G+GS+ TT Sbjct: 118 TRIRLGVHTGLFMGAIRGSGTKEQYDYWVRKGAADVKGFYGCFAMTELGHGSNVAGLETT 177 Query: 170 AR--EEGDSWVLN-----GTKAWITN-SWEASATVVFASTDRSRQNKGISAFLVPMPT-- 219 A ++ D +++N TK WI + A+ T FA ++ G+ F+V + Sbjct: 178 ATYIQDTDEFIINTPNTGATKWWIGGAAHSATHTACFARLLVDGKDYGVKIFVVQLRDVS 237 Query: 220 -----PGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLL------------GEPGMGFK 262 PG+ LG K+G A + F + RIP++N+L +P + + Sbjct: 238 SHSLMPGIALGDIGKKMGRDAIDNGWIQFTNVRIPRQNMLMKYAKVSSTGKVSQPPLA-Q 296 Query: 263 IAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGA----PLTKL 307 + L GR+ + + + ++Q + A++YA R FG P TK+ Sbjct: 297 LTYGALIGGRVTMIADSFFVSQRFITIALRYACVRRQFGTTPGQPETKI 345 >4Y9J-A nrPDB Length = 593 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 72/271 (26%), Positives = 123/271 (45%), Gaps = 26/271 (9%) Query: 154 LSEPGNGSD-AGAASTTARE-EGDSWVLNGTKAWITNSWEASATVVFASTDRSRQN---- 207 ++E GSD AG T A + + D++ L+G K W +++ +A + A S N Sbjct: 190 MTEKKGGSDVAGGCDTYAVQIDKDTYRLHGYK-WFSSAVDADVALTLARIVDSDGNALEG 248 Query: 208 -KGISAFLVPMPTP-----GLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGF 261 +G+S FL+ + G+ + + ++KLG + TA L+ + + +G+ G G Sbjct: 249 SRGLSLFLLKIRDESGNLNGIQMVRLKNKLGTKQLPTAELLLDGAIAER---IGDQGRGV 305 Query: 262 KIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALAL 321 L++ RI A +LG + + A Y+ R FG +K LA M + Sbjct: 306 AGISNMLNITRIHNAVASLGYMRRIISLARDYSTKRVVFGQTQSKWPLHTTTLAKMEVDT 365 Query: 322 ESARLLTWRAAML---KDNKKPFTKESAMA-------KLAASEAATAISHQAIQILGGMG 371 + LL + AA L + K E+ M KL A + A + + I+ GG G Sbjct: 366 RGSMLLLFEAARLLGLSEAGKSSDVEAMMLRLITPVLKLYAGKQAVPMVSEGIECFGGQG 425 Query: 372 YVTEMPAERYYRDARITEIYEGTSEIQRLVI 402 Y+ + RDA++T I+EGT+ + L + Sbjct: 426 YMEDTGLPTLLRDAQVTPIWEGTTNVLSLDV 456 >4JEK-A nrPDB Length = 453 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 92/377 (24%), Positives = 159/377 (42%), Gaps = 31/377 (8%) Query: 45 CRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEE 104 R AEK A + D+ T++ + + GLL++ VP E G G D+ + E Sbjct: 60 ARGLAEKWRA-TAVERDRAGGSATAEREDLRASGLLSLLVPREYGGWGADWPTAIEVVRE 118 Query: 105 ISRGCASTGVIMSVNNSLYLGPILKF-GSSQQKQQWITPFTNGDKIGCFALSEPGNGSDA 163 I+ S G + + L P+++ GS +Q++ T + A SE + Sbjct: 119 IAAADGSLGHLFGYH--LTNAPMIELIGSQEQEEHLYTQIAQNNWWTGNASSENNSHVLD 176 Query: 164 GAASTTAREEGDSWVLNGTKAWITNSWEASATVVFAST-DRSRQNKGISAFLVPMPTPGL 222 S T E+G +VLNGTK + + + + VF D S Q I A +P G+ Sbjct: 177 WKVSATPTEDG-GYVLNGTKHFCSGAKGSDLLFVFGVVQDDSPQQGAIIAAAIPTSRAGV 235 Query: 223 TLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMG-------RIGI 275 T +G+R + + + F + ++ + +LG P F +A + G ++ Sbjct: 236 TPNDDWAAIGMRQTDSGSTDFHNVKVEPDEVLGAPN-AFVLAFIQSERGSLFAPIAQLIF 294 Query: 276 ASQALGIAQASLDCAVKYAEN----------RHAFGAPLTKLQNIQFKLA---DMALALE 322 A+ LGIA +LD A +Y + A P T +F +A A A E Sbjct: 295 ANVYLGIAHGALDAAREYTRTQARPWTPAGIQQATEDPYTIRSYGEFTIALQGADAAARE 354 Query: 323 SARLL--TWRA--AMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPA 378 +A LL W A+ +++ + + K A+ AA IS +++G G Sbjct: 355 AAHLLQTVWDKGDALTPEDRGELMVKVSGVKALATNAALNISSGVFEVIGARGTHPRYGF 414 Query: 379 ERYYRDARITEIYEGTS 395 +R++R+ R +++ S Sbjct: 415 DRFWRNVRTHSLHDPVS 431 >5XDD-A nrPDB Length = 414 Score = 64.7 bits (156), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 81/354 (22%), Positives = 149/354 (42%), Gaps = 34/354 (9%) Query: 67 PTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGP 126 P ++ + GLL + + +E G G + A+ EI+ AS G + + S + Sbjct: 42 PKAERDAIRRSGLLTLLISKERGGLGESWPTVYEAIAEIASADASLGHLFGYHFSNFAYV 101 Query: 127 ILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWI 186 L F S +QK +W A SE + T +G S+ +NGTKA+ Sbjct: 102 DL-FASPEQKARWYPQAVRERWFLGNASSENNAHVLDWRVTATPLPDG-SYEINGTKAFC 159 Query: 187 TNSWEASATVVFASTDRSRQNKG-ISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFED 245 + S +A +VFA T R G I A L+P G+ + D LG+R + + ++ F Sbjct: 160 SGSADADRLLVFAVTSRDPNGDGRIVAALIPSDRAGVQVNGDWDSLGMRQTDSGSVTFSG 219 Query: 246 CRIPKENLLGEPGM-------GFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRH 298 + + LLG PG G K ++ T + ++ LGIA+ +L+ A Y+ + Sbjct: 220 VVVYPDELLGTPGQVTDAFASGSKPSLWT-PITQLIFTHLYLGIARGALEEAAHYSRSHS 278 Query: 299 -------------------AFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKK 339 +G +LQ + ++AL ++ L R + + + Sbjct: 279 RPFTLAGVEKATEDPYVLAIYGEFAAQLQVAEAGAREVALRVQE---LWERNHVTPEQRG 335 Query: 340 PFTKESAMAKLAASEAATAISHQAIQILGGMGYVT-EMPAERYYRDARITEIYE 392 + A AK+ A+ ++ + + +G + + +R++RDAR +++ Sbjct: 336 QLMVQVASAKIVATRLVIELTSRLYEAMGARAAASRQFGFDRFWRDARTHTLHD 389 >4XVX-A nrPDB Length = 389 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 80/362 (22%), Positives = 156/362 (43%), Gaps = 18/362 (4%) Query: 50 EKELVPIAAQLDKEHLFPTSQVKKMGELGLL----AMDVPEELSGAGLDYLAYSIALEEI 105 ++ +V A+ + + FP ++ +G G+ A D ++ + + AL ++ Sbjct: 22 DERVVAWTAEAEAQERFPRQLIEHLGVCGVFDAKWATDARPDVG----KLVELAFALGQL 77 Query: 106 SRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGA 165 + A GV +S+++S + + +FG S + G + C SE GSD Sbjct: 78 A--SAGIGVGVSLHDS-AIAILRRFGKSDYLRDICDQAIRGAAVLCIGASEESGGSDLQI 134 Query: 166 ASTTAREEGDSWVLNGTKAWITNSWEASATVVFA-STDRSRQNKGISAFLVPMPTPGLTL 224 T R + + G K +++ S A +V A S D ++ + +V +P +++ Sbjct: 135 VETEIRSRDGGFEVRGVKKFVSLSPIADHIMVVARSVDHDPTSRHGNVAVVAVPAAQVSV 194 Query: 225 GKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQ 284 K+G TA + D +P + L+ G G L R+ IA Q Q Sbjct: 195 QTPYRKVGAGPLDTAAVCI-DTWVPADALVARAGTGLAAISWGLAHERMSIAGQIAASCQ 253 Query: 285 ASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKE 344 ++ + +R FG L + Q ++ ++AD+ ++ LL + + + + + Sbjct: 254 RAIGITLARMMSRRQFGQTLFEHQALRLRMADLQARVD---LLRYALHGIAEQGRLELRT 310 Query: 345 SAMAKLAASEAATAISHQAIQILGGMGY-VTEMPAERYYRDARITEIYEGTSEI-QRLVI 402 +A K+ A+ + + + I GG GY V E +++RD ++ + GT E+ LV Sbjct: 311 AAAVKVTAARLGEEVISECMHIFGGAGYLVDETTLGKWWRDMKLARVGGGTDEVLWELVA 370 Query: 403 AG 404 AG Sbjct: 371 AG 372 >1W07-A nrPDB Length = 659 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 49/202 (24%), Positives = 93/202 (46%), Gaps = 30/202 (14%) Query: 131 GSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAR--EEGDSWVLNGTKAWITN 188 G+ +Q+++W++ IGC+A +E G+GS+ TTA + D +V++ + Sbjct: 114 GTEEQQKKWLSLANKMQIIGCYAQTELGHGSNVQGLETTATLDPKTDEFVIHTPTQTASK 173 Query: 189 SWE------ASATVVFASTDRSRQNKGISAFLVPM-------PTPGLTLGKKEDKLGIRA 235 W ++ VV+A + ++ GI F+V + P P +T+G K+G A Sbjct: 174 WWPGGLGKVSTHAVVYARLITNGKDYGIHGFIVQLRSLEDHSPLPNITVGDIGTKMGNGA 233 Query: 236 SSTAN---LIFEDCRIPKENLL---------GE---PGMGFKIAMQTLDMGRIGIASQAL 280 ++ + L+F+ RIP++ +L GE + ++ T+ R I + A Sbjct: 234 YNSMDNGFLMFDHVRIPRDQMLMRLSKVTREGEYVPSDVPKQLVYGTMVYVRQTIVADAS 293 Query: 281 GIAQASLDCAVKYAENRHAFGA 302 ++ A +Y+ R FGA Sbjct: 294 NALSRAVCIATRYSAVRRQFGA 315 >1IS2-A nrPDB Length = 661 Score = 55.1 bits (131), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 48/201 (23%), Positives = 87/201 (43%), Gaps = 31/201 (15%) Query: 69 SQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPIL 128 + VKKM E G+ PEE+ + RG + ++ ++L +L Sbjct: 69 TMVKKMREYGI---SDPEEIMWFK----------NSVHRGHPEP---LDLHLGMFLPTLL 112 Query: 129 KFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDS--WVLNGTKAWI 186 +++Q++++ P N + G +A +E G+G+ TTA + + ++LN Sbjct: 113 HQATAEQQERFFMPAWNLEITGTYAQTEMGHGTHLRGLETTATYDPKTQEFILNSPTVTS 172 Query: 187 TNSWE------ASATVVFASTDRSRQNKGISAFLVPM-------PTPGLTLGKKEDKLGI 233 W ++ +V A + G+ AF+VP+ P PG+T+G K G Sbjct: 173 IKWWPGGLGKTSNHAIVLAQLITQGECYGLHAFVVPIREIGTHKPLPGITVGDIGPKFGY 232 Query: 234 RASSTANLIFEDCRIPKENLL 254 L ++ RIP+EN+L Sbjct: 233 EEMDNGYLKMDNYRIPRENML 253 >2FON-A nrPDB Length = 683 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 38/151 (25%), Positives = 74/151 (49%), Gaps = 18/151 (11%) Query: 122 LYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAR--EEGDSWVL 179 +++ I G+ +Q+++W+ IGC+A +E G+GS+ TTA + D +V+ Sbjct: 124 MFIPAIKGQGTDKQQEKWLPLAYKMQIIGCYAQTELGHGSNVQGLETTATFDPQTDEFVI 183 Query: 180 NGTKAWITNSWE------ASATVVFASTDRSRQNKGISAFLVPM-------PTPGLTLGK 226 + + W ++ VV+A ++ G++ F+V + P PG+T+G Sbjct: 184 HSPTLTSSKWWPGGLGKVSTHAVVYARLITDGKDYGVNGFIVQLRSLEDHKPLPGVTVGD 243 Query: 227 KEDKLGIRASSTAN---LIFEDCRIPKENLL 254 K G A ++ + L F+ RIP++ +L Sbjct: 244 IGMKFGNGAYNSMDNGVLSFDHVRIPRDQML 274 >5K3G-A nrPDB Length = 684 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 40/157 (25%), Positives = 70/157 (44%), Gaps = 15/157 (9%) Query: 113 GVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTARE 172 G M+++ +++ + S +Q+ +W+ + IG +A +E G+G++ TTA Sbjct: 110 GNPMALHGVMFIPALNAQASDEQQAKWLIRALRREIIGTYAQTEMGHGTNLQNLETTATY 169 Query: 173 E--GDSWVLNGTKAWITNSW------EASATVVFASTDRSRQNKGISAFLVPM------- 217 + +VL+ K W ++ VV A +N G F+VP+ Sbjct: 170 DIGTQEFVLHTPKITALKWWPGNLGKSSNYAVVVAHMYIKGKNFGPHTFMVPLRDEKTHK 229 Query: 218 PTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLL 254 P PG+T+G K+ L F + RIP+ NLL Sbjct: 230 PLPGITIGDIGPKMAYNIVDNGFLGFNNYRIPRTNLL 266 >5K3J-A nrPDB Length = 674 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 38/157 (24%), Positives = 70/157 (44%), Gaps = 15/157 (9%) Query: 113 GVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTARE 172 G +++++L++ + S +Q+++W+ + IGC+A +E G+GS+ TTA Sbjct: 108 GHPFALHDALFIPTLQSQASDEQQEKWLERARRREIIGCYAQTELGHGSNLRNLETTAVY 167 Query: 173 E--GDSWVLNGTKAWITNSW------EASATVVFASTDRSRQNKGISAFLVPM------- 217 + +VL+ W + +V A R N G F+V + Sbjct: 168 DIASQEFVLHTPTTTALKWWPGALGKSCNYALVVAELIIKRNNYGPHFFMVQLRDEKTHI 227 Query: 218 PTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLL 254 P G+T+G K+ A+ L + R+P+ NLL Sbjct: 228 PLKGVTVGDIGPKMNFNAADNGYLGLNNLRVPRTNLL 264 >2RFQ-A nrPDB Length = 394 Score = 44.7 bits (104), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 71/371 (19%), Positives = 139/371 (37%), Gaps = 57/371 (15%) Query: 66 FPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLG 125 P +K + E G + PE+ G D + + A+ +I+ C STG + S+ ++ Sbjct: 36 IPDDSMKALQETGFFRLLQPEQWGGYQADPVLFYSAVRKIASACGSTGWVSSIIG-VHNW 94 Query: 126 PILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTA-----REEGDSWVLN 180 + F Q+ W GN +D +S+ A + + +N Sbjct: 95 HLALFSQQAQEDVW------------------GNDTDVRISSSYAPMGAGQVVDGGYTVN 136 Query: 181 GTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTAN 240 G AW + AS V+ + + +FL+P + + +G+R + + Sbjct: 137 GAWAWSSGCDHASWAVLGGPVIKDGRPVDFVSFLIPRED--YRIDDVWNVVGLRGTGSNT 194 Query: 241 LIFEDCRIPKENLLG--------EPGMGFKIA-MQTLDMGRIG---IASQALGIAQASLD 288 ++ ED +P +L PG+ A + + G I I++ +G+A + D Sbjct: 195 VVVEDVFVPTHRVLSFKAMSNLTAPGLERNTAPVYKMPWGTIHPTTISAPIVGMAYGAYD 254 Query: 289 CAVKYAEN--RHAFGAPLTKLQNI-QFKLADMALALESARLLTWR----------AAMLK 335 V++ R AF K + ++A+ + +++A WR A ++ Sbjct: 255 AHVEHQGKRVRAAFAGEKAKDDPFAKVRIAEASSDIDAA----WRQLSGNVADEYALLVA 310 Query: 336 DNKKPFTKESAMAKLAASEAATAIS--HQAIQILGGMGYVTEMPAERYYRDARITEIYEG 393 + PF + AIS + + G P +R++RDA ++ Sbjct: 311 GEEVPFELRLRARRDQVRATGRAISSIDKLFESSGATALANGTPLQRFWRDAHAGRVHAA 370 Query: 394 TSEIQRLVIAG 404 + V+ G Sbjct: 371 NDPERAYVMYG 381 >3AFF-A nrPDB Length = 394 Score = 38.9 bits (89), Expect = 0.004, Method: Compositional matrix adjust. Identities = 72/368 (19%), Positives = 137/368 (37%), Gaps = 49/368 (13%) Query: 66 FPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLG 125 P VK + ++G + P++ G D + A ++ C STG + S+ ++ Sbjct: 36 LPDETVKALDDVGFFTLLQPQQWGGLQCDPALFFEATRRLASVCGSTGWVSSIVG-VHNW 94 Query: 126 PILKFGSSQQKQQW-ITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKA 184 + F Q++ W P T +A G D G +++NG+ Sbjct: 95 HLALFDQRAQEEVWGEDPSTRISS--SYAPMGAGVVVDGG------------YLVNGSWN 140 Query: 185 WITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFE 244 W + AS T V + + +FL+P + +G+R + + L+ + Sbjct: 141 WSSGCDHASWTFVGGPVIKDGRPVDFGSFLIPRSE--YEIKDVWYVVGLRGTGSNTLVVK 198 Query: 245 DCRIPKENLLGEPGMGFKIA------------MQTLDMGRIGIASQALGIAQASLDCAVK 292 D +P+ L M A M M I++ +G+A + V+ Sbjct: 199 DVFVPRHRFLSYKAMNDHTAGGLATNSAPVYKMPWGTMHPTTISAPIVGMAYGAYAAHVE 258 Query: 293 YAEN--RHAFGAPLTKLQNI-QFKLADMALALESARLLTWRA---------AMLKDNKK- 339 + R AF K + ++A+ A +++A WR A+L K+ Sbjct: 259 HQGKRVRAAFAGEKAKDDPFAKVRIAEAASDIDAA----WRQLIGNVSDEYALLAAGKEI 314 Query: 340 PFT--KESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEI 397 PF + ++ A+ + A + + G E P +R++RDA ++ Sbjct: 315 PFELRARARRDQVRATGRSIASIDRLFEASGATALSNEAPIQRFWRDAHAGRVHAANDPE 374 Query: 398 QRLVIAGH 405 + VI G+ Sbjct: 375 RAYVIFGN 382 >5LVW-A nrPDB Length = 413 Score = 33.1 bits (74), Expect = 0.23, Method: Compositional matrix adjust. Identities = 80/356 (22%), Positives = 141/356 (39%), Gaps = 49/356 (13%) Query: 58 AQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTG-VIM 116 A+ ++E P + V+ + + L + + G D S + +S C ST V+ Sbjct: 47 AEGERERRLPDATVRAIDQSQLAMLWTAKSYGGLETDVRTMSEVAKVLSHYCPSTSWVVN 106 Query: 117 SVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDS 176 +VN S L KF + + + GD G S AA T R G Sbjct: 107 NVNGSNLLAS--KFPRAALDEVF------GDAPGAKL------ASVFAAAGTAVRTPG-G 151 Query: 177 WVLNGTKAWIT----NSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLG 232 + L G+ + T + W A +V D + G + LVP LT+ +G Sbjct: 152 YRLTGSWPYGTGILHDDW---AILVAREVDADGEPVGGLSMLVP--ARDLTVEDTWHTVG 206 Query: 233 IRASSTANLIFEDCRIPKENLL-GE--------PGMGFKIAMQTLDMGRIGI--ASQALG 281 +RA+ + ++ D +P+ ++ GE +G +T + + + AS LG Sbjct: 207 MRATGSHTVVLRDTFVPEHRVISGELQRSRESATDLGLPPLFRTAAIAAMAVVCASVVLG 266 Query: 282 IAQASLDCAVKYAENRHAFGAPLTKLQNIQF---KLADMALALESARLLTWRAAMLKDN- 337 QA+ V+ A R + T+ + + L AL++++A + RAA D+ Sbjct: 267 AGQAARALVVEKAPTRGIAPSKYTRQTDSRTFVSSLGRTALSIDAAEMHVARAATALDDA 326 Query: 338 --KKPFTKESAMAKL------AASEAATAISHQAIQILGGMGYVTEMPAERYYRDA 385 +S + ++ A S TA+ + + G + P +RY+RDA Sbjct: 327 AYDAVALPDSELLRIRGDVGQAVSLVTTALD-ELLWAHGAASFAESNPLQRYWRDA 381 >3CF4-A nrPDB Length = 807 Score = 32.3 bits (72), Expect = 0.38, Method: Compositional matrix adjust. Identities = 19/64 (29%), Positives = 29/64 (45%) Query: 1 MAAALLARAGGSLGRALRARDWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQL 60 MA A + + S+GRA++ W LH Y + PE +T D + +L Sbjct: 709 MAKACIRPSDNSMGRAIKLTHWMELHKKYLGGKEPEDWWKFVRTEADLPLATREALLKEL 768 Query: 61 DKEH 64 +KEH Sbjct: 769 EKEH 772 >2OR0-A nrPDB Length = 414 Score = 29.6 bits (65), Expect = 2.4, Method: Compositional matrix adjust. Identities = 36/185 (19%), Positives = 71/185 (38%), Gaps = 33/185 (17%) Query: 229 DKLGIRASSTANLIFEDCRIPKENLL--------------GEPGMGFKIAMQTLDMGRIG 274 D +G+R + + +LI + +P L G P F + M +G Sbjct: 200 DVIGLRGTGSKDLIVDGAFVPGYRTLNAAKVMDGRAQKEAGRPEPLFNMPYSC--MFPLG 257 Query: 275 IASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAML 334 I + +GI + +L C + ++R A K++ + L+ A+ +A + R +++ Sbjct: 258 ITAAVIGITEGALACHIAVQKDRVAITG--QKIKEDPYVLS--AIGESAAEINASRVSLI 313 Query: 335 KDNKKPFTKESAMAKLAASEAATAISHQAIQIL-------------GGMGYVTEMPAERY 381 + + + K A ++ E A Q GG + P +R+ Sbjct: 314 ETADRFYDKVDAGKEITFEERAIGRRTQIAAAWRAVRAADEIFARAGGGALHYKTPMQRF 373 Query: 382 YRDAR 386 +RDA Sbjct: 374 WRDAH 378 >2PH3-A nrPDB Length = 245 Score = 29.6 bits (65), Expect = 2.6, Method: Compositional matrix adjust. Identities = 13/23 (56%), Positives = 18/23 (78%) Query: 348 AKLAASEAATAISHQAIQILGGM 370 A L +EAATA+ HQA ++LGG+ Sbjct: 59 ANLLEAEAATALVHQAAEVLGGL 81 >4AF0-B nrPDB Length = 556 Score = 29.6 bits (65), Expect = 2.9, Method: Compositional matrix adjust. Identities = 13/61 (21%), Positives = 27/61 (44%) Query: 340 PFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQR 399 P + + + A A+ A+ + G + TE P E +Y + + ++Y G I+ Sbjct: 386 PCIADGGIGNIGHIAKALALGASAVMMGGLLAGTTESPGEYFYHEGKRVKVYRGMGSIEA 445 Query: 400 L 400 + Sbjct: 446 M 446 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1JQI-A nrPDB 545 e-155 2VIG-A nrPDB 519 e-148 5OL2-C nrPDB 494 e-140 4L1F-A nrPDB 482 e-136 5LNX-A nrPDB 475 e-134 4N5F-A nrPDB 473 e-134 4U83-A nrPDB 467 e-132 6FAH-C nrPDB 465 e-131 1UKW-A nrPDB 457 e-129 4M9A-A nrPDB 454 e-128 1BUC-A nrPDB 452 e-127 2A1T-A nrPDB 450 e-127 4O5M-A nrPDB 446 e-126 3PFD-A nrPDB 439 e-124 2JIF-A nrPDB 438 e-123 3MDE-A nrPDB 437 e-123 1IVH-A nrPDB 437 e-123 4KTO-A nrPDB 429 e-120 1RX0-A nrPDB 419 e-118 2DVL-A nrPDB 413 e-116 2PG0-A nrPDB 410 e-115 4IV6-A nrPDB 407 e-114 6ES9-A nrPDB 401 e-112 3MPI-A nrPDB 399 e-111 3GNC-A nrPDB 398 e-111 4IRN-A nrPDB 394 e-110 3NF4-A nrPDB 393 e-110 2Z1Q-A nrPDB 391 e-109 3OWA-A nrPDB 387 e-108 2CX9-A nrPDB 386 e-107 2EBA-A nrPDB 380 e-106 1SIR-A nrPDB 378 e-105 3SF6-A nrPDB 378 e-105 4W9U-A nrPDB 369 e-102 3SWO-A nrPDB 366 e-101 3R7K-A nrPDB 364 e-101 2IX5-A nrPDB 364 e-101 3B96-A nrPDB 363 e-101 5ZW7-A nrPDB 360 e-100 6CY8-B nrPDB 358 3e-99 3P4T-A nrPDB 347 6e-96 5AHS-A nrPDB 344 3e-95 5IDU-A nrPDB 338 2e-93 5JSC-A nrPDB 313 1e-85 4RM7-A nrPDB 308 3e-84 2WBI-A nrPDB 299 2e-81 4HR3-A nrPDB 297 6e-81 1R2J-A nrPDB 260 7e-70 4X28-A nrPDB 258 3e-69 5GJ7-A nrPDB 257 8e-69 5XDD-A nrPDB 232 2e-61 3M9V-A nrPDB 231 4e-61 2C12-A nrPDB 229 2e-60 4ZYJ-A nrPDB 222 2e-58 4JEK-A nrPDB 222 2e-58 3MXL-A nrPDB 217 7e-57 5EZ3-A nrPDB 215 4e-56 3MKH-A nrPDB 214 6e-56 4X28-D nrPDB 211 4e-55 5YS9-A nrPDB 210 9e-55 3U33-A nrPDB 209 2e-54 5Y9D-A nrPDB 206 2e-53 4XVX-A nrPDB 206 2e-53 4Y9J-A nrPDB 199 3e-51 2RFQ-A nrPDB 181 5e-46 1W07-A nrPDB 179 2e-45 2FON-A nrPDB 179 2e-45 1IS2-A nrPDB 179 2e-45 5K3G-A nrPDB 160 1e-39 5K3J-A nrPDB 157 1e-38 Sequences not found previously or not previously below threshold: 3AFF-A nrPDB 157 1e-38 2JBS-A nrPDB 121 4e-28 5LVW-A nrPDB 106 1e-23 2OR0-A nrPDB 93 2e-19 3HWC-A nrPDB 46 3e-05 2YYI-A nrPDB 40 0.002 4G5E-A nrPDB 40 0.003 1U8V-A nrPDB 38 0.011 1REO-A nrPDB 35 0.046 1F8S-A nrPDB 35 0.058 3J8G-X nrPDB 33 0.37 4AYX-A nrPDB 32 0.60 4QNW-A nrPDB 30 1.8 2XSG-A nrPDB 30 3.0 2Q3R-A nrPDB 29 3.4 3DR5-A nrPDB 29 3.6 3TD7-A nrPDB 29 3.7 2X5D-A nrPDB 29 4.0 3L73-B nrPDB 29 5.1 1AKL-A nrPDB 28 9.9 >1JQI-A nrPDB Length = 388 Score = 545 bits (1404), Expect = e-155, Method: Composition-based stats. Identities = 387/388 (99%), Positives = 388/388 (100%) Query: 25 LHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDV 84 LH+VYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDV Sbjct: 1 LHSVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDV 60 Query: 85 PEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFT 144 PEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFT Sbjct: 61 PEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFT 120 Query: 145 NGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRS 204 NGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRS Sbjct: 121 NGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRS 180 Query: 205 RQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIA 264 RQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIA Sbjct: 181 RQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIA 240 Query: 265 MQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESA 324 MQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESA Sbjct: 241 MQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESA 300 Query: 325 RLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRD 384 RLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRD Sbjct: 301 RLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRD 360 Query: 385 ARITEIYEGTSEIQRLVIAGHLLRSYRS 412 ARITEIYEGTSEIQRLVIAGHLLRSYRS Sbjct: 361 ARITEIYEGTSEIQRLVIAGHLLRSYRS 388 >2VIG-A nrPDB Length = 391 Score = 519 bits (1337), Expect = e-148, Method: Composition-based stats. Identities = 351/383 (91%), Positives = 366/383 (95%) Query: 30 QSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELS 89 QSVELPETHQML QTCRDFAEKEL PIAAQ+DKEHLFP +QVKKMG LGLLAMDVPEEL Sbjct: 2 QSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELG 61 Query: 90 GAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKI 149 GAGLDYLAY+IA+EEISRGCASTGVIMSVNNSLYLGPILKFGS +QKQ W+TPFT+GDKI Sbjct: 62 GAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLGPILKFGSKEQKQAWVTPFTSGDKI 121 Query: 150 GCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKG 209 GCFALSEPGNGSDAGAASTTAR EGDSWVLNGTKAWITN+WEASA VVFASTDR+ QNK Sbjct: 122 GCFALSEPGNGSDAGAASTTARAEGDSWVLNGTKAWITNAWEASAAVVFASTDRALQNKS 181 Query: 210 ISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLD 269 ISAFLVPMPTPGLTLGKKEDKLGIR SSTANLIFEDCRIPK+++LGEPGMGFKIAMQTLD Sbjct: 182 ISAFLVPMPTPGLTLGKKEDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLD 241 Query: 270 MGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTW 329 MGRIGIASQALGIAQ +LDCAV YAENR AFGAPLTKLQ IQFKLADMALALESARLLTW Sbjct: 242 MGRIGIASQALGIAQTALDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTW 301 Query: 330 RAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITE 389 RAAMLKDNKKPF KE+AMAKLAASEAATAISHQAIQILGGMGYVTEMPAER+YRDARITE Sbjct: 302 RAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITE 361 Query: 390 IYEGTSEIQRLVIAGHLLRSYRS 412 IYEGTSEIQRLVIAGHLLRSYRS Sbjct: 362 IYEGTSEIQRLVIAGHLLRSYRS 384 >5OL2-C nrPDB Length = 378 Score = 494 bits (1272), Expect = e-140, Method: Composition-based stats. Identities = 195/374 (52%), Positives = 269/374 (71%) Query: 35 PETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLD 94 + +QML++ FAE E+ P+A +LD+E FP V+KM + G++ + P+E G G D Sbjct: 5 SKKYQMLKELYVSFAENEVKPLATELDEEERFPYETVEKMAKAGMMGIPYPKEYGGEGGD 64 Query: 95 YLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFAL 154 + Y +A+EE+SR C +TGVI+S + SL PI ++G+ +QKQ+++ P +G+K+G F L Sbjct: 65 TVGYIMAVEELSRVCGTTGVILSAHTSLGSWPIYQYGNEEQKQKFLRPLASGEKLGAFGL 124 Query: 155 SEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFL 214 +EP G+DA TTA +GD ++LNG+K +ITN+ VV A TD+S+ NKGISAF+ Sbjct: 125 TEPNAGTDASGQQTTAVLDGDEYILNGSKIFITNAIAGDIYVVMAMTDKSKGNKGISAFI 184 Query: 215 VPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIG 274 V TPG + G KE K+GIR S+T+ LIFEDCRIPKENLLG+ G GFKIAM TLD GRIG Sbjct: 185 VEKGTPGFSFGVKEKKMGIRGSATSELIFEDCRIPKENLLGKEGQGFKIAMSTLDGGRIG 244 Query: 275 IASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAML 334 IA+QALG+AQ +LD VKY + R FG PL+K QN QF+LADM + +++AR L ++AA+ Sbjct: 245 IAAQALGLAQGALDETVKYVKERVQFGRPLSKFQNTQFQLADMEVKVQAARHLVYQAAIN 304 Query: 335 KDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGT 394 KD KP+ E+AMAKL A+E A ++ +A+Q+ GG GY + P ER RDA+ITEIYEGT Sbjct: 305 KDLGKPYGVEAAMAKLFAAETAMEVTTKAVQLHGGYGYTRDYPVERMMRDAKITEIYEGT 364 Query: 395 SEIQRLVIAGHLLR 408 SE+QR+VI+G LL+ Sbjct: 365 SEVQRMVISGKLLK 378 >4L1F-A nrPDB Length = 383 Score = 482 bits (1241), Expect = e-136, Method: Composition-based stats. Identities = 186/381 (48%), Positives = 254/381 (66%) Query: 31 SVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSG 90 L E QM++ +FAEK L P + DK H++ + KMGE G + PEE G Sbjct: 2 DFNLTEDQQMIKDMAAEFAEKFLAPTVEERDKAHIWDRKLIDKMGEAGFCGICFPEEYGG 61 Query: 91 AGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIG 150 GLD L+Y +A+EE+S+ TG+ +S N SL PI FG+ +QKQ+++ P G +G Sbjct: 62 MGLDVLSYILAVEELSKVDDGTGITLSANVSLCATPIYMFGTEEQKQKYLAPIAEGTHVG 121 Query: 151 CFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGI 210 F L+EP G+DA A TTA +GD ++LNG+K +ITN EA VVFA TD+S+ GI Sbjct: 122 AFGLTEPSAGTDASAQQTTAVLKGDKYILNGSKIFITNGKEADTYVVFAMTDKSQGVHGI 181 Query: 211 SAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDM 270 SAF++ PG GK EDK+G S TA LIFEDC +PKENLLG+ G GFKIAM+TLD Sbjct: 182 SAFILEKGMPGFRFGKIEDKMGGHTSITAELIFEDCEVPKENLLGKEGEGFKIAMETLDG 241 Query: 271 GRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWR 330 GRIG+A+QALGIA+ +L AVKY++ R FG ++K Q +QF +ADMA +E+AR L + Sbjct: 242 GRIGVAAQALGIAEGALAAAVKYSKEREQFGRSISKFQALQFMMADMATKIEAARYLVYH 301 Query: 331 AAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEI 390 AAMLK+ KP+++ +AMAK AS+ A ++ A+QI GG GY + PAERY R+A+IT+I Sbjct: 302 AAMLKNEGKPYSEAAAMAKCFASDVAMEVTTDAVQIFGGYGYTVDYPAERYMRNAKITQI 361 Query: 391 YEGTSEIQRLVIAGHLLRSYR 411 YEGT+++ R+V + LLR + Sbjct: 362 YEGTNQVMRIVTSRALLRDKK 382 >5LNX-A nrPDB Length = 379 Score = 475 bits (1222), Expect = e-134, Method: Composition-based stats. Identities = 182/376 (48%), Positives = 254/376 (67%) Query: 32 VELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGA 91 + + + M+R+ RDFA KE+ P A ++K FP +KKMG+ GL+ + VPE+ GA Sbjct: 1 MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMGKHGLMGIPVPEQYGGA 60 Query: 92 GLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGC 151 G D ++Y +A+ EISR A+ GVI+SV+ S+ PIL FG+ +QK ++I +GD +G Sbjct: 61 GADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNEEQKMKYIPNLASGDHLGA 120 Query: 152 FALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGIS 211 FAL+EP +GSDAG+ TTA ++ ++LNG+K +ITN A + FA T + GIS Sbjct: 121 FALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGAADIYITFALTAPDQGRHGIS 180 Query: 212 AFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMG 271 AF+V TPG T+GKKE KLG+ S+T LIF++ +P+ NLLG+ G GF IAM L++G Sbjct: 181 AFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVPEANLLGKEGDGFHIAMANLNVG 240 Query: 272 RIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRA 331 RIGIA+QALGIA+A+L+ AV YA+ R FG P+ Q I FKLADMA E+AR L + A Sbjct: 241 RIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAANQGISFKLADMATRAEAARHLVYHA 300 Query: 332 AMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIY 391 A L + KE++MAK AS+AA + A+QI GG GY+ + P ER RDA++T+IY Sbjct: 301 ADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQIYGGYGYMKDYPVERLLRDAKVTQIY 360 Query: 392 EGTSEIQRLVIAGHLL 407 EGT+EIQRL+I+ +LL Sbjct: 361 EGTNEIQRLIISKYLL 376 >4N5F-A nrPDB Length = 385 Score = 473 bits (1218), Expect = e-134, Method: Composition-based stats. Identities = 187/372 (50%), Positives = 242/372 (65%) Query: 35 PETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLD 94 E +M+R R FA + L P AAQ D + P + V ++GELGLL M VP+EL G+ D Sbjct: 14 TEDQRMIRDAARAFATEMLAPNAAQWDHDAHLPDAIVAQLGELGLLGMIVPQELGGSYTD 73 Query: 95 YLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFAL 154 Y+AY++A+EE++ G A+ +MSV+NS+ GPIL FG+ QK +W+ G IG F L Sbjct: 74 YVAYALAMEEVAAGDAACATMMSVHNSVGCGPILGFGTPAQKDRWLADMAAGRVIGAFCL 133 Query: 155 SEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFL 214 +EP GS+A T A WVLNG K ++TN A +VFA TD +GISAFL Sbjct: 134 TEPHAGSEANNLRTRAELRDGQWVLNGAKQFVTNGQRAGVAIVFAMTDPEAGKRGISAFL 193 Query: 215 VPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIG 274 VP TPG +GK E K+GIRAS T + FE+C IP++NLLG G G KIA+ L+ GRIG Sbjct: 194 VPTDTPGFIVGKPEKKMGIRASDTCPITFENCAIPEDNLLGNRGEGLKIALSNLEGGRIG 253 Query: 275 IASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAML 334 IA+QALGIA+A+ D A +YA R FG P+ + Q IQ KLADMA+ + +ARLL AA L Sbjct: 254 IAAQALGIARAAFDKARRYAGERVQFGKPIAEHQAIQQKLADMAVQINAARLLVHHAAKL 313 Query: 335 KDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGT 394 + P E++ AKL ASE A + AIQI GG GY+ + ER+YRDARIT+IYEGT Sbjct: 314 RTAGLPCLSEASQAKLFASEMAERVCSDAIQIHGGYGYLVDYEVERHYRDARITQIYEGT 373 Query: 395 SEIQRLVIAGHL 406 SE+QR+VIA L Sbjct: 374 SEVQRMVIARQL 385 >4U83-A nrPDB Length = 382 Score = 467 bits (1201), Expect = e-132, Method: Composition-based stats. Identities = 176/375 (46%), Positives = 248/375 (66%) Query: 32 VELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGA 91 + L +T + +R+ RDFA++ L P AA D+EH FP +++ +MG LG L M PEE G+ Sbjct: 8 MLLTDTQEQIREAARDFAQERLAPGAAARDREHAFPRAELTEMGALGFLGMLAPEEWGGS 67 Query: 92 GLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGC 151 LD +AY++ALEEI+ G + I+SV++S+ PIL+FG+ QK++++ G+ IG Sbjct: 68 DLDMVAYALALEEIAAGDGACSTIVSVHSSVGCMPILRFGTEDQKRRFLPKMACGEWIGG 127 Query: 152 FALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGIS 211 FAL+EP GSDA A T AR +GD +V++G+K +IT+ + +VFA TD + KGIS Sbjct: 128 FALTEPQAGSDASALKTRARLDGDHYVIDGSKQFITSGKNGNVVIVFAVTDPAAGKKGIS 187 Query: 212 AFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMG 271 AF+VP TPG + E KLG +S T L F + R+P EN LG G G+KIA+ L+ G Sbjct: 188 AFIVPTDTPGYEVMSVEHKLGQHSSDTCALGFTNMRVPVENRLGAEGEGYKIALANLEGG 247 Query: 272 RIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRA 331 RIGIA+QA+G+A+A+ + A YA R FG P+ + Q + F+LADMA +E+AR + A Sbjct: 248 RIGIAAQAVGMARAAFEAARDYARERITFGKPIIEHQAVAFRLADMATRIETARQMVLHA 307 Query: 332 AMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIY 391 A L++ KP E++MAKL ASE A + AIQI GG GY+ + P ER YRD R+ +IY Sbjct: 308 AALREAGKPCLTEASMAKLVASEMAEQVCSAAIQIHGGYGYLADYPVERIYRDVRVCQIY 367 Query: 392 EGTSEIQRLVIAGHL 406 EGTS++QRLVIA L Sbjct: 368 EGTSDVQRLVIARGL 382 >6FAH-C nrPDB Length = 379 Score = 465 bits (1198), Expect = e-131, Method: Composition-based stats. Identities = 171/379 (45%), Positives = 250/379 (65%), Gaps = 1/379 (0%) Query: 32 VELPETHQMLRQTCRDFAEKELV-PIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSG 90 + E ++M+R+ RDFAEKEL I ++++ FP + KM + G + +P+ L G Sbjct: 1 MYFSEQNKMIRKLARDFAEKELTTEILDEVEESGEFPQEILDKMAKFGFFGIKIPKSLGG 60 Query: 91 AGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIG 150 +G D+++Y I +EE +R V +S NSL GP+L G+ +Q ++++ P G K Sbjct: 61 SGGDHMSYVICMEEFARVSGVASVYLSSPNSLAGGPLLLSGTEEQIEKYLKPIITGKKKL 120 Query: 151 CFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGI 210 FAL+EPG GSDAG STTA + GD ++LNG K +IT + V++A TD S+ +GI Sbjct: 121 AFALTEPGAGSDAGGMSTTAVDMGDYYLLNGRKTFITMAPLCDDAVIYAKTDMSKGTRGI 180 Query: 211 SAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDM 270 SAF+V + + G+++GK E K+G+ +T+++I ED ++PKEN LGE GF AM+TLD+ Sbjct: 181 SAFIVDLKSEGVSMGKNEHKMGLIGCATSDIIMEDVKVPKENRLGEVNKGFSNAMKTLDV 240 Query: 271 GRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWR 330 GR+G+ASQ++G+AQ +LD A+KYA+ R FG + Q I F +ADMA LE+A+LL + Sbjct: 241 GRLGVASQSIGVAQGALDEAIKYAKERKQFGKRIADFQAIAFMIADMATKLEAAKLLVYN 300 Query: 331 AAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEI 390 AA L DNKK TKE++MAK ASE I +A+QI GG GY+ E ER YRD R+ I Sbjct: 301 AASLMDNKKNATKEASMAKFYASEICNEICAKAVQIHGGYGYIKEYKVERMYRDCRVFTI 360 Query: 391 YEGTSEIQRLVIAGHLLRS 409 YEGTS++Q++VI+G LL+ Sbjct: 361 YEGTSQVQQMVISGMLLKK 379 >1UKW-A nrPDB Length = 379 Score = 457 bits (1176), Expect = e-129, Method: Composition-based stats. Identities = 170/379 (44%), Positives = 238/379 (62%), Gaps = 1/379 (0%) Query: 31 SVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSG 90 L E + L+ R FA++ ++P+A + D++ P ++K+ E+GLL +PEE G Sbjct: 2 DFSLTEEQRQLQALARRFAKEVILPVAQEYDEKEEVPWPVIEKLHEVGLLNAIIPEEYGG 61 Query: 91 AGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIG 150 GL L I EE++ C + + + L + P+L G+ +QK++++ P T + Sbjct: 62 MGLKMLDEVIVGEELAYACMGI-YTIPMASDLGITPVLLAGTEEQKERFLRPLTEKPALA 120 Query: 151 CFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGI 210 FALSEPGNGSDA A T A +GD +VLNGTK WI+N EA VVFA+ + ++KG+ Sbjct: 121 AFALSEPGNGSDAAALKTRAIRQGDHYVLNGTKMWISNGGEAEWVVVFATVNPELRHKGV 180 Query: 211 SAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDM 270 A +V TPG K K+G RAS T L+FED ++P EN LGE G GFKIAMQTL+ Sbjct: 181 VALVVERGTPGFKAIKIHGKMGQRASGTYELVFEDVKVPVENRLGEEGEGFKIAMQTLNK 240 Query: 271 GRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWR 330 RI +A+ ++G+A+ +LD A KYA+ R AFG P+ Q IQFKL DM + +E+AR+ T+ Sbjct: 241 TRIPVAAGSVGVARRALDEARKYAKEREAFGEPIANFQAIQFKLVDMLIGIETARMYTYY 300 Query: 331 AAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEI 390 AA L D P SA+AK ASE A ++QAIQI GG GYV E P E+ RD ++ +I Sbjct: 301 AAWLADQGLPHAHASAIAKAYASEIAFEAANQAIQIHGGYGYVREFPVEKLLRDVKLNQI 360 Query: 391 YEGTSEIQRLVIAGHLLRS 409 YEGT+EIQRL+IA H+L + Sbjct: 361 YEGTNEIQRLIIARHILAA 379 >4M9A-A nrPDB Length = 385 Score = 454 bits (1168), Expect = e-128, Method: Composition-based stats. Identities = 179/372 (48%), Positives = 243/372 (65%) Query: 35 PETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLD 94 E +M+ R F + L P AAQ D+E P V +MGELG L M VP + G+ D Sbjct: 14 TEDQRMILDAARAFCAEVLAPNAAQWDRESHLPDEVVAQMGELGFLGMIVPADWGGSYTD 73 Query: 95 YLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFAL 154 Y+AY++ALEEI+ GCAS ++SV+NS+ GP+L +G+++QK++W+ +G +G F+L Sbjct: 74 YVAYALALEEIAAGCASCATLVSVHNSVGCGPVLNYGTTEQKERWLRDLASGKTVGAFSL 133 Query: 155 SEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFL 214 +EP GS+A T A W+LNG+K ++TN A +VFA TD +G+SAF+ Sbjct: 134 TEPHAGSEAHNLRTRAELRDGKWILNGSKQFVTNGARAGLAIVFAMTDPDEGKRGLSAFV 193 Query: 215 VPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIG 274 VP TPG +GK E K+GIRAS T + E+C IP+ENLLG+ G G KIA+ L+ GRIG Sbjct: 194 VPTDTPGFIVGKPEKKMGIRASDTCPITLENCAIPQENLLGKRGEGLKIALSNLEGGRIG 253 Query: 275 IASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAML 334 IA+QA GIA+A+ D A +YA R FG P+ + Q I KLA+MA + +ARLLT AA L Sbjct: 254 IAAQATGIARAAFDRARRYARERVQFGKPIAEHQAIAEKLANMATQINAARLLTHHAARL 313 Query: 335 KDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGT 394 + P E++ AKL ASE A A+ AIQI GG G++ + ER+YRDARIT+IYEGT Sbjct: 314 RTAGLPCLSEASQAKLFASEMAEAVCSDAIQIHGGYGFLVDYEVERHYRDARITQIYEGT 373 Query: 395 SEIQRLVIAGHL 406 SE+QR+VIA L Sbjct: 374 SEVQRMVIARQL 385 >1BUC-A nrPDB Length = 383 Score = 452 bits (1162), Expect = e-127, Method: Composition-based stats. Identities = 169/382 (44%), Positives = 244/382 (63%), Gaps = 4/382 (1%) Query: 31 SVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSG 90 L + Q + DF EK+L P + D + ++ + ++ LG+ E+ G Sbjct: 2 DFNLTDIQQDFLKLAHDFGEKKLAPTVTERDHKGIYDKELIDELLSLGITGAYFEEKYGG 61 Query: 91 AGLD---YLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGD 147 +G D L+Y +A+EE+++ A + +S SL PI +FG+ QK++++ P G Sbjct: 62 SGDDGGDVLSYILAVEELAKYDAGVAITLSATVSLCANPIWQFGTEAQKEKFLVPLVEGT 121 Query: 148 KIGCFALSEPGNGSDAGAASTTARE-EGDSWVLNGTKAWITNSWEASATVVFASTDRSRQ 206 K+G F L+EP G+DA T A + + ++ LNG+K +ITN A +VFA TD+S+ Sbjct: 122 KLGAFGLTEPNAGTDASGQQTIATKNDDGTYTLNGSKIFITNGGAADIYIVFAMTDKSKG 181 Query: 207 NKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQ 266 N GI+AF++ TPG T GKKEDK+GI S T L+F+D ++P EN+LGE G GFKIAM Sbjct: 182 NHGITAFILEDGTPGFTYGKKEDKMGIHTSQTMELVFQDVKVPAENMLGEEGKGFKIAMM 241 Query: 267 TLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARL 326 TLD GRIG+A+QALGIA+A+L AV+Y++ R FG PL K Q+I FKLADM + +E+AR Sbjct: 242 TLDGGRIGVAAQALGIAEAALADAVEYSKQRVQFGKPLCKFQSISFKLADMKMQIEAARN 301 Query: 327 LTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDAR 386 L ++AA K KPFT ++A+AK AS+ A ++ +A+QI GG GY E P R+ RDA+ Sbjct: 302 LVYKAACKKQEGKPFTVDAAIAKRVASDVAMRVTTEAVQIFGGYGYSEEYPVARHMRDAK 361 Query: 387 ITEIYEGTSEIQRLVIAGHLLR 408 IT+IYEGT+E+Q +V G LLR Sbjct: 362 ITQIYEGTNEVQLMVTGGALLR 383 >2A1T-A nrPDB Length = 421 Score = 450 bits (1159), Expect = e-127, Method: Composition-based stats. Identities = 153/410 (37%), Positives = 233/410 (56%), Gaps = 13/410 (3%) Query: 15 RALRARDWRRLHTVYQ---------SVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHL 65 R++ WR HT S E E + + T R FA +E++P+AA+ DK Sbjct: 13 RSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREEIIPVAAEYDKTGE 72 Query: 66 FPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLG 125 +P +++ ELGL+ +PE G GL + EE++ GC + NSL Sbjct: 73 YPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQTAIE-GNSLGQM 131 Query: 126 PILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAW 185 PI+ G+ QQK++++ T + + ++EPG GSD T A ++GD +++NG K W Sbjct: 132 PIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMW 191 Query: 186 ITNSWEASATVVFASTDRSRQ---NKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLI 242 ITN +A+ + A +D + NK + F+V TPG+ +G+KE +G R S T ++ Sbjct: 192 ITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIV 251 Query: 243 FEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGA 302 FED ++PKEN+L G GFK+AM D R +A+ A+G+AQ +LD A KYA R FG Sbjct: 252 FEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGK 311 Query: 303 PLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQ 362 L + Q I F LA+MA+ +E AR+ RAA D+ + T +++AK A + A ++ Sbjct: 312 LLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLATD 371 Query: 363 AIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRSYRS 412 A+QILGG G+ TE P E+ RDA+I +IYEGTS+IQRL++A + Y++ Sbjct: 372 AVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN 421 >4O5M-A nrPDB Length = 390 Score = 446 bits (1147), Expect = e-126, Method: Composition-based stats. Identities = 156/380 (41%), Positives = 224/380 (58%) Query: 32 VELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGA 91 L E + LR T R FAE + P+AA+ D+ + FP ++ GELG+L + PE+ GA Sbjct: 11 FGLGEEIEALRDTVRRFAESRIAPLAAETDRNNQFPMHLWREFGELGVLGITAPEDYGGA 70 Query: 92 GLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGC 151 G+ YLA+ IA+EEISR AS G+ +++L + I + GS +Q+ +++ +G+ +G Sbjct: 71 GMGYLAHCIAMEEISRASASIGLSYGAHSNLCVNQITRNGSPEQRAKYLPKLISGEHVGA 130 Query: 152 FALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGIS 211 A+SEPG GSD + A + GD +VLNG K WITN +A VV+A TD S +GIS Sbjct: 131 LAMSEPGAGSDVVSMKLAAEKRGDRYVLNGNKMWITNGPDADVLVVYAKTDLSAGPRGIS 190 Query: 212 AFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMG 271 AF++ G + +K DKLG+R S+T L+FEDC +P ENLLG G G + M LD Sbjct: 191 AFIIEKGFKGFSTAQKLDKLGMRGSNTCELVFEDCEVPAENLLGTEGKGVNVLMSGLDYE 250 Query: 272 RIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRA 331 R+ +A LGI A LD V Y R F P+ + Q +Q KLADM + ++R + Sbjct: 251 RVVLAGGPLGIMAACLDVVVPYVHERKQFDQPIGEFQLMQCKLADMYVTFNASRAYVYAV 310 Query: 332 AMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIY 391 A D + K++A L ++E AT ++ QAIQ LGG GY+ + P R RDA++ EI Sbjct: 311 AAACDRGETTRKDAAGCILYSAENATQMALQAIQSLGGNGYINDYPTGRLLRDAKLYEIG 370 Query: 392 EGTSEIQRLVIAGHLLRSYR 411 GTSEI+R++I L + R Sbjct: 371 AGTSEIRRMLIGRELFQETR 390 >3PFD-A nrPDB Length = 393 Score = 439 bits (1130), Expect = e-124, Method: Composition-based stats. Identities = 164/381 (43%), Positives = 236/381 (61%), Gaps = 2/381 (0%) Query: 29 YQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEEL 88 ++ +LPE H LR+ R AEKE+ P AA++D++ FP + + G A+ VPEE Sbjct: 14 FELFQLPEEHIALREAIRALAEKEIAPYAAEVDEKARFPEEALAALNSSGFSAIHVPEEY 73 Query: 89 SGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDK 148 G G D +A I +EE++R S +I +VN +G IL+ GS + K+Q + +G+ Sbjct: 74 GGQGADSVATCIVIEEVARVDCSASLIPAVNKLGTMGLILR-GSEELKKQVLPAVASGEA 132 Query: 149 IGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNK 208 + +ALSE GSDA + T A +GD W+LNG+K WITN +++ V A TD + Sbjct: 133 MASYALSEREAGSDAASMRTRAVADGDDWILNGSKCWITNGGKSTWYTVMAVTDPDKGAN 192 Query: 209 GISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTL 268 GISAF+V G T+G KE KLGI+ S T L FE+CRIP + ++GEPG GFK A+ TL Sbjct: 193 GISAFMVHKDDEGFTVGPKERKLGIKGSPTTELYFENCRIPGDRIIGEPGTGFKTALATL 252 Query: 269 DMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLT 328 D R I +QA+GIAQ +LD A+ Y + R FG P++ Q +QF LADMA+ +E+ARL+ Sbjct: 253 DHTRPTIGAQAVGIAQGALDAAIAYTKERKQFGRPVSDNQGVQFMLADMAMKIEAARLMV 312 Query: 329 WRAAMLKDNKKPFTKESAMA-KLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARI 387 + AA + + + A K AS+ A ++ A+Q+ GG GY + P ER RDA+I Sbjct: 313 YSAAARAERGEGDLGFISAASKCFASDVAMEVTTDAVQLFGGYGYTQDFPVERMMRDAKI 372 Query: 388 TEIYEGTSEIQRLVIAGHLLR 408 T+IYEGT++IQR+V++ LLR Sbjct: 373 TQIYEGTNQIQRVVMSRALLR 393 >2JIF-A nrPDB Length = 404 Score = 438 bits (1126), Expect = e-123, Method: Composition-based stats. Identities = 152/384 (39%), Positives = 237/384 (61%), Gaps = 1/384 (0%) Query: 27 TVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPE 86 ++ + M++ + + FA++++ P+ + +D+ S ++ + + GL+ ++V Sbjct: 22 SMAPLQTFTDEEMMIKSSVKKFAQEQIAPLVSTMDENSKMEKSVIQGLFQQGLMGIEVDP 81 Query: 87 ELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNG 146 E G G +L+ + +EE+++ AS V + N+L I K G+ +QK ++ T Sbjct: 82 EYGGTGASFLSTVLVIEELAKVDASVAVFCEIQNTLINTLIRKHGTEEQKATYLPQLTT- 140 Query: 147 DKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQ 206 +K+G F LSE G GSD+ A T A +EGD +VLNG+K WI+++ A +V A+ D + Sbjct: 141 EKVGSFCLSEAGAGSDSFALKTRADKEGDYYVLNGSKMWISSAEHAGLFLVMANVDPTIG 200 Query: 207 NKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQ 266 KGI++FLV TPGL +GK E+KLG+RASST L FE+ ++P+ N+LG+ G G+K A+ Sbjct: 201 YKGITSFLVDRDTPGLHIGKPENKLGLRASSTCPLTFENVKVPEANILGQIGHGYKYAIG 260 Query: 267 TLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARL 326 +L+ GRIGIA+Q LG+AQ D + Y + R FG L Q +Q ++A +A LE+ARL Sbjct: 261 SLNEGRIGIAAQMLGLAQGCFDYTIPYIKERIQFGKRLFDFQGLQHQVAHVATQLEAARL 320 Query: 327 LTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDAR 386 LT+ AA L + KPF KE++MAK ASE A + + I+ +GG+GY + P E+Y+RDA+ Sbjct: 321 LTYNAARLLEAGKPFIKEASMAKYYASEIAGQTTSKCIEWMGGVGYTKDYPVEKYFRDAK 380 Query: 387 ITEIYEGTSEIQRLVIAGHLLRSY 410 I IYEG S IQ IA H+ Y Sbjct: 381 IGTIYEGASNIQLNTIAKHIDAEY 404 >3MDE-A nrPDB Length = 385 Score = 437 bits (1125), Expect = e-123, Method: Composition-based stats. Identities = 147/384 (38%), Positives = 228/384 (59%), Gaps = 4/384 (1%) Query: 31 SVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSG 90 S EL E + + T R FA +E++P+AA+ D+ +P +K+ ELGL+ +PE G Sbjct: 3 SFELTEQQKEFQATARKFAREEIIPVAAEYDRTGEYPVPLLKRAWELGLMNTHIPESFGG 62 Query: 91 AGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIG 150 GL + + EE++ GC + N+L P++ G+ QQ+++++ T + Sbjct: 63 LGLGIIDSCLITEELAYGCTGVQTAIEA-NTLGQVPLIIGGNYQQQKKYLGRMTEEPLMC 121 Query: 151 CFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQ---N 207 + ++EPG GSD T A ++GD +++NG K WITN +A+ + A +D + + Sbjct: 122 AYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPAS 181 Query: 208 KGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQT 267 K + F+V TPG+ +G+KE +G R S T ++FED R+PKEN+L G GFKIAM T Sbjct: 182 KAFTGFIVEADTPGVQIGRKEINMGQRCSDTRGIVFEDVRVPKENVLTGEGAGFKIAMGT 241 Query: 268 LDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLL 327 D R +A+ A+G+AQ +LD A KYA R FG L + Q I F LADMA+ +E ARL Sbjct: 242 FDKTRPPVAAGAVGLAQRALDEATKYALERKTFGKLLAEHQGISFLLADMAMKVELARLS 301 Query: 328 TWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARI 387 RAA D+ + T +++AK A++ A ++ A+Q+ GG G+ TE P E+ RDA+I Sbjct: 302 YQRAAWEIDSGRRNTYYASIAKAYAADIANQLATDAVQVFGGNGFNTEYPVEKLMRDAKI 361 Query: 388 TEIYEGTSEIQRLVIAGHLLRSYR 411 +IYEGT++IQR++IA + Y+ Sbjct: 362 YQIYEGTAQIQRIIIAREHIGRYK 385 >1IVH-A nrPDB Length = 394 Score = 437 bits (1125), Expect = e-123, Method: Composition-based stats. Identities = 139/378 (36%), Positives = 214/378 (56%), Gaps = 4/378 (1%) Query: 33 ELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFP--TSQVKKMGELGLLAMDVPEELSG 90 L E + LRQT F ++ L P A ++D+ + F K++G LG+L + P + G Sbjct: 12 GLSEEQRQLRQTMAKFLQEHLAPKAQEIDRSNEFKNLREFWKQLGNLGVLGITAPVQYGG 71 Query: 91 AGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIG 150 +GL YL + + +EEISR + G+ +++L + +++ G+ QK++++ +G+ IG Sbjct: 72 SGLGYLEHVLVMEEISRASGAVGLSYGAHSNLCINQLVRNGNEAQKEKYLPKLISGEYIG 131 Query: 151 CFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRS--RQNK 208 A+SEP GSD + A ++G+ ++LNG K WITN +A +V+A TD + ++ Sbjct: 132 ALAMSEPNAGSDVVSMKLKAEKKGNHYILNGNKFWITNGPDADVLIVYAKTDLAAVPASR 191 Query: 209 GISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTL 268 GI+AF+V PG + KK DKLG+R S+T LIFEDC+IP N+LG G + M L Sbjct: 192 GITAFIVEKGMPGFSTSKKLDKLGMRGSNTCELIFEDCKIPAANILGHENKGVYVLMSGL 251 Query: 269 DMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLT 328 D+ R+ +A LG+ QA LD + Y R AFG + Q +Q K+ADM L + R Sbjct: 252 DLERLVLAGGPLGLMQAVLDHTIPYLHVREAFGQKIGHFQLMQGKMADMYTRLMACRQYV 311 Query: 329 WRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARIT 388 + A D K+ A L ++E AT ++ IQ GG GY+ + P R+ RDA++ Sbjct: 312 YNVAKACDEGHCTAKDCAGVILYSAECATQVALDGIQCFGGNGYINDFPMGRFLRDAKLY 371 Query: 389 EIYEGTSEIQRLVIAGHL 406 EI GTSE++RLVI Sbjct: 372 EIGAGTSEVRRLVIGRAF 389 >4KTO-A nrPDB Length = 410 Score = 429 bits (1104), Expect = e-120, Method: Composition-based stats. Identities = 159/380 (41%), Positives = 227/380 (59%) Query: 32 VELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGA 91 L E LR + R FA + + P+A D+ + FP S ++MGELGLL + E GA Sbjct: 31 FALGEEIDALRASVRRFASERIAPLADDADRSNAFPMSLWREMGELGLLGITADEAHGGA 90 Query: 92 GLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGC 151 GL YLA+ +A+EEISR AS G+ +++L + I + G QK +++ +G+ +G Sbjct: 91 GLGYLAHCVAMEEISRASASVGLSYGAHSNLCVNQINRNGKPAQKSRYLPKLISGEHVGA 150 Query: 152 FALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGIS 211 A+SEPG GSD + A + GD +VLNG+K WITN +A VV+A TD + +GI+ Sbjct: 151 LAMSEPGAGSDVVSMKLKADKRGDRYVLNGSKMWITNGPDADVLVVYAKTDPAAGPRGIT 210 Query: 212 AFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMG 271 AFLV PG + G+K DKLG+R S+T+ LIF DC +P+EN+LG G G K+ M LD Sbjct: 211 AFLVEKAFPGFSAGQKLDKLGMRGSNTSELIFTDCEVPEENVLGGVGEGVKVLMSGLDYE 270 Query: 272 RIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRA 331 R+ +++ LGI A LD V Y R FG P+ + Q +Q KLADM + + +AR + Sbjct: 271 RVVLSAGPLGIMAACLDVVVPYLHERKQFGQPIGEFQLMQGKLADMYVTMNAARAYVYAV 330 Query: 332 AMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIY 391 A D + K++A L A+E ATA++ +AIQ LGG GY + PA R RDA++ EI Sbjct: 331 AAACDRGETARKDAAGCILYAAEKATAMALEAIQALGGNGYTNDYPAGRLLRDAKLYEIG 390 Query: 392 EGTSEIQRLVIAGHLLRSYR 411 GTSEI+R++I L + Sbjct: 391 AGTSEIRRMLIGRELFAETK 410 >1RX0-A nrPDB Length = 393 Score = 419 bits (1078), Expect = e-118, Method: Composition-based stats. Identities = 144/381 (37%), Positives = 228/381 (59%), Gaps = 3/381 (0%) Query: 30 QSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELS 89 S+ L E + ++ DFA +E+ P A+ D++ LFP ++K +LG + + ++ Sbjct: 15 PSMGLNEEQKEFQKVAFDFAAREMAPNMAEWDQKELFPVDVMRKAAQLGFGGVYIQTDVG 74 Query: 90 GAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKI 149 G+GL L S+ E ++ GC ST +S++N + I FG+ +Q+ ++ P +K Sbjct: 75 GSGLSRLDTSVIFEALATGCTSTTAYISIHN-MCAWMIDSFGNEEQRHKFCPPLCTMEKF 133 Query: 150 GCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKG 209 + L+EPG+GSDA + T+A+++GD ++LNG+KA+I+ + E+ VV T KG Sbjct: 134 ASYCLTEPGSGSDAASLLTSAKKQGDHYILNGSKAFISGAGESDIYVVMCRTG-GPGPKG 192 Query: 210 ISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLD 269 IS +V TPGL+ GKKE K+G + T +IFEDC +P N +G G GF IA++ L+ Sbjct: 193 ISCIVVEKGTPGLSFGKKEKKVGWNSQPTRAVIFEDCAVPVANRIGSEGQGFLIAVRGLN 252 Query: 270 MGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTW 329 GRI IAS +LG A AS+ + R FG PL Q +QF LADMA L +ARL+ Sbjct: 253 GGRINIASCSLGAAHASVILTRDHLNVRKQFGEPLASNQYLQFTLADMATRLVAARLMVR 312 Query: 330 RAA-MLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARIT 388 AA L++ +K +MAKL A++ AI +QA+Q+ GG GY+ + ++Y RD+R+ Sbjct: 313 NAAVALQEERKDAVALCSMAKLFATDECFAICNQALQMHGGYGYLKDYAVQQYVRDSRVH 372 Query: 389 EIYEGTSEIQRLVIAGHLLRS 409 +I EG++E+ R++I+ LL+ Sbjct: 373 QILEGSNEVMRILISRSLLQE 393 >2DVL-A nrPDB Length = 372 Score = 413 bits (1063), Expect = e-116, Method: Composition-based stats. Identities = 171/377 (45%), Positives = 240/377 (63%), Gaps = 5/377 (1%) Query: 32 VELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGA 91 + L + +++ R A + L P+A + D++ +P Q+K + ELGLL M PEE G Sbjct: 1 MTLTQEQRLVLDAVRRVAREVLYPLAPEYDRKAEYPWPQLKALAELGLLGMTTPEEWGGV 60 Query: 92 GLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGC 151 GLD + +++ALEE++ S VI+SV + L +L+FGS QK++++ P G+ IG Sbjct: 61 GLDSVTWALALEELAAADPSVAVIVSVTSGLPQYMLLRFGSEAQKRRYLVPLARGEWIGA 120 Query: 152 FALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGIS 211 F L+EP GSDA + AR +VLNG K+WIT++ A VV A T+ KGIS Sbjct: 121 FCLTEPQAGSDAKSLRAEARRVKGGFVLNGVKSWITSAGHAHLYVVMARTE-----KGIS 175 Query: 212 AFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMG 271 AFLV TPGL+ G+ E+K+G+ A+ TA + E+ +P+ENLLGE G G A+ LD G Sbjct: 176 AFLVEKGTPGLSFGRPEEKMGLHAAHTAEVRLEEVFVPEENLLGEEGRGLAYALAGLDSG 235 Query: 272 RIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRA 331 R+G+A+QA+GIA+ + + A YAE R FG L + Q I FK+ADM + + +AR L A Sbjct: 236 RVGVAAQAVGIARGAFEIAKAYAEEREQFGKKLKEHQAIAFKIADMHVKIAAARALVLEA 295 Query: 332 AMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIY 391 A KD + FT E++ AKL AS AA ++ +A+Q+LGG GY + ERYYRDA++TEIY Sbjct: 296 ARKKDRGERFTLEASAAKLFASAAAVEVTREAVQVLGGYGYHRDYRVERYYRDAKVTEIY 355 Query: 392 EGTSEIQRLVIAGHLLR 408 EGTSEIQRLVIA L R Sbjct: 356 EGTSEIQRLVIARELYR 372 >2PG0-A nrPDB Length = 385 Score = 410 bits (1055), Expect = e-115, Method: Composition-based stats. Identities = 134/375 (35%), Positives = 198/375 (52%), Gaps = 3/375 (0%) Query: 34 LPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGL 93 L E H M R R F EKE P +K + P S KMGE G L V E+ G Sbjct: 10 LREEHHMFRAAFRKFLEKEAYPHYNDWEKRGIIPRSFWAKMGENGFLCPWVDEKYGGLNA 69 Query: 94 DYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFA 153 D+ + EE+ + +S V + ++N + I +G+ +QKQ+W+ G+ I A Sbjct: 70 DFAYSVVINEELEKVGSSL-VGIGLHNDIVTPYIASYGTEEQKQKWLPKCVTGELITAIA 128 Query: 154 LSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQ--NKGIS 211 ++EPG GSD STTA ++GD +++NG K +ITN A VV TD + ++GIS Sbjct: 129 MTEPGAGSDLANISTTAVKDGDYYIVNGQKTFITNGIHADLIVVACKTDPQAKPPHRGIS 188 Query: 212 AFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMG 271 +V TPG T G+K +K+G+ A TA L F+D ++P NLLGE G GF M+ L Sbjct: 189 LLVVERDTPGFTRGRKLEKVGLHAQDTAELFFQDAKVPAYNLLGEEGKGFYYLMEKLQQE 248 Query: 272 RIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRA 331 R+ +A A A+ +Y + R AFG +++ Q +QF+LA+MA + R R Sbjct: 249 RLVVAIAAQTAAEVMFSLTKQYVKQRTAFGKRVSEFQTVQFRLAEMATEIALGRTFVDRV 308 Query: 332 AMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIY 391 K E +MAK +E A ++ +A+Q+ GG GY+ E R YRD ++ IY Sbjct: 309 IEEHMAGKQIVTEVSMAKWWITEMAKRVAAEAMQLHGGYGYMEEYEIARRYRDIPVSAIY 368 Query: 392 EGTSEIQRLVIAGHL 406 GT+E+ + +IA L Sbjct: 369 AGTNEMMKTIIARQL 383 >4IV6-A nrPDB Length = 388 Score = 407 bits (1047), Expect = e-114, Method: Composition-based stats. Identities = 134/383 (34%), Positives = 213/383 (55%), Gaps = 5/383 (1%) Query: 30 QSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELS 89 S+ L + + +T DF EK++ P+ +L+ + +P ++ M E+G+ + +PE Sbjct: 3 GSMALTAEEETIVKTVHDFVEKQVKPVVRELEHANTYPEELIETMKEIGIFGLAIPEPYG 62 Query: 90 GAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKI 149 + Y EE++RG S M + + +L FG+ +QKQ+++ G+ Sbjct: 63 FGAVSMPCYVQVAEELARGWMSLAGAMGGHT-VVSKLLLLFGTEEQKQKYLPRMATGELR 121 Query: 150 GCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRS--RQN 207 AL+EPG GSD A T AR +GD +V+NG+K WI+N+ + + TD + Sbjct: 122 ATMALTEPGGGSDLQAMRTVARRDGDDYVINGSKTWISNARRSDLVALMCKTDPDAQPAH 181 Query: 208 KGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGE-PGMGFKIAMQ 266 KG+S LV PG + + KLG + + L F D R+P +LLG+ G GF M+ Sbjct: 182 KGVSILLVEK-VPGFDVSRDLPKLGYKGVESCELNFTDARVPVSSLLGDDEGRGFAQMMK 240 Query: 267 TLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARL 326 L++GR+ +A++A G+A+A+ + A++Y++ R +FG P+ + Q++ LADM L +AR Sbjct: 241 GLEVGRLQVAARATGVARAAFEDALRYSQERESFGKPIWQHQSVGNMLADMGTKLYAARS 300 Query: 327 LTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDAR 386 L AA D + E+ MAKL ASE A I+ A+++ GG GY TE ERY+RDA Sbjct: 301 LLLSAAEKFDAGQRCDMEAGMAKLFASETAMQIALDAVRVHGGYGYSTEYDVERYFRDAP 360 Query: 387 ITEIYEGTSEIQRLVIAGHLLRS 409 + + EGT+EIQR VIA L+ Sbjct: 361 LMIVGEGTNEIQRNVIAKQLVAR 383 >6ES9-A nrPDB Length = 551 Score = 401 bits (1031), Expect = e-112, Method: Composition-based stats. Identities = 149/420 (35%), Positives = 221/420 (52%), Gaps = 16/420 (3%) Query: 2 AAALLARAGGSLGRALRARDWRRLH--TVYQSVELPETHQMLRQTCRDFAEKELVPIAAQ 59 AAA L R + RA AR + H + + L E +M+R R +AE+ ++P A + Sbjct: 133 AAAKLMRGNTAPARAELARLMQDNHGRATFGATGLDEDLEMIRDQFRRYAEERVIPNAHE 192 Query: 60 LD-KEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSV 118 K+ L P ++++ ELG+ + +PEE G GL + + EE+SRG G + Sbjct: 193 WHLKDQLIPMEIIEELAELGVFGLTIPEEFGGLGLSKASMVVVTEELSRGYIGVGS-LGT 251 Query: 119 NNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWV 178 + + IL G+ QK +W+ +G+ + +EP GSD G+ T A +G+ WV Sbjct: 252 RSEIAAELILCGGTEAQKAKWLPGLASGEILSTAVFTEPNTGSDLGSLRTRAVRDGEDWV 311 Query: 179 LNGTKAWITNSWEASATVVFASTDRSRQN-KGISAFLVPM---------PTPGLTLGKKE 228 + G K WIT++ + A TD + +G+S FL PTPG+T G+ E Sbjct: 312 VTGNKTWITHAQRTHVMTLLARTDPETTDWRGLSMFLAEKEPGTDDDPFPTPGMTGGEIE 371 Query: 229 DKLGIRASSTANLIFEDCRIPKENLLG-EPGMGFKIAMQTLDMGRIGIASQALGIAQASL 287 LG R L F+ RI ENLLG EPG GFK M+T + RI A++A+G+AQ++ Sbjct: 372 -VLGYRGMKEYELGFDGFRIKGENLLGGEPGRGFKQLMETFESARIQTAARAVGVAQSAA 430 Query: 288 DCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAM 347 + ++YA +R FG L + + KLA MA+ + AR LT+ +A KD+ + E+ M Sbjct: 431 EIGMRYAVDRKQFGKSLIEFPRVADKLAMMAVEIMIARQLTYFSAWEKDHGRRCDLEAGM 490 Query: 348 AKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLL 407 AKL + A A + A+QI GG G+ E R DARI I+EG +EIQ VIA LL Sbjct: 491 AKLLGARVAWAAADNALQIHGGNGFALEYAISRVLCDARILNIFEGAAEIQAQVIARRLL 550 >3MPI-A nrPDB Length = 397 Score = 399 bits (1025), Expect = e-111, Method: Composition-based stats. Identities = 149/387 (38%), Positives = 233/387 (60%), Gaps = 6/387 (1%) Query: 31 SVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQ-VKKMGELGLLAMDVPEELS 89 L + QML++ R+F K++VP A Q D E+ FP + V+ MGELG +PEE Sbjct: 2 DFNLSKELQMLQKEVRNFVNKKIVPFADQWDNENHFPYEEAVRPMGELGFFGTVIPEEYG 61 Query: 90 GAGLD--YLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGD 147 G G+D +LA I EEI+RG ++ V +++ IL +GS K++++ ++ + Sbjct: 62 GEGMDQGWLAAMIVTEEIARGSSALRVQLNMEVLGCAYTILTYGSEALKKKYVPKLSSAE 121 Query: 148 KIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQN 207 +G F ++EP GSD A S+TA ++GD W+LNG+K WI+N+ +A + +A TD++ + Sbjct: 122 FLGGFGITEPDAGSDVMAMSSTAEDKGDHWLLNGSKTWISNAAQADVLIYYAYTDKAAGS 181 Query: 208 KGISAFLV-PMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQ 266 +G+SAF++ P PG+ E KLG AS T L ++ ++PKEN+LG+PG G +I Sbjct: 182 RGLSAFVIEPRNFPGIKTSNLE-KLGSHASPTGELFLDNVKVPKENILGKPGDGARIVFG 240 Query: 267 TLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARL 326 +L+ R+ A+ +G+AQA LD A+KY R FG P+ Q Q +A MA+ +E+ARL Sbjct: 241 SLNHTRLSAAAGGVGLAQACLDAAIKYCNERRQFGKPIGDFQMNQDMIAQMAVEVEAARL 300 Query: 327 LTWRAAMLKDNKK-PFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDA 385 L ++AA KD + + AMAK AA EA + ++ A++ILG GY TE P R+YRDA Sbjct: 301 LAYKAAAAKDEGRLNNGLDVAMAKYAAGEAVSKCANYAMRILGAYGYSTEYPVARFYRDA 360 Query: 386 RITEIYEGTSEIQRLVIAGHLLRSYRS 412 + EG++ I +++IA L ++ Sbjct: 361 PTYYMVEGSANICKMIIALDQLGVRKA 387 >3GNC-A nrPDB Length = 399 Score = 398 bits (1023), Expect = e-111, Method: Composition-based stats. Identities = 122/390 (31%), Positives = 196/390 (50%), Gaps = 4/390 (1%) Query: 16 ALRARDWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMG 75 A W + +L + +M+R +A+ +L P + + + ++MG Sbjct: 6 AAATFHWDDPLLL--DQQLADDERMVRDAAHAYAQGKLAPRVTEAFRHETTDAAIFREMG 63 Query: 76 ELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQ 135 E+GLL +PE+ G GLDY++Y + E+ R + +MSV +SL + PI +FGS Q Sbjct: 64 EIGLLGPTIPEQYGGPGLDYVSYGLIAREVERVDSGYRSMMSVQSSLVMVPIFEFGSDAQ 123 Query: 136 KQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASAT 195 K++++ G+ IGCF L+EP +GSD G+ T AR+ + L+G+K WITNS A Sbjct: 124 KEKYLPKLATGEWIGCFGLTEPNHGSDPGSMVTRARKVPGGYSLSGSKMWITNSPIADVF 183 Query: 196 VVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLG 255 VV+A D +++ I F++ GL+ K+G+RAS T ++ ++ +P+EN+L Sbjct: 184 VVWAKLDEDGRDE-IRGFILEKGCKGLSAPAIHGKVGLRASITGEIVLDEAFVPEENILP 242 Query: 256 EPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLA 315 G + L+ R GIA ALG A++ A +Y +R FG PL Q IQ KLA Sbjct: 243 HV-KGLRGPFTCLNSARYGIAWGALGAAESCWHIARQYVLDRKQFGRPLAANQLIQKKLA 301 Query: 316 DMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTE 375 DM + R +KD + +++ K + A I+ A +LGG G E Sbjct: 302 DMQTEITLGLQGVLRLGRMKDEGTAAVEITSIMKRNSCGKALDIARLARDMLGGNGISDE 361 Query: 376 MPAERYYRDARITEIYEGTSEIQRLVIAGH 405 R+ + + YEGT +I L++ Sbjct: 362 FGVARHLVNLEVVNTYEGTHDIHALILGRA 391 >4IRN-A nrPDB Length = 416 Score = 394 bits (1013), Expect = e-110, Method: Composition-based stats. Identities = 127/378 (33%), Positives = 202/378 (53%), Gaps = 2/378 (0%) Query: 31 SVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSG 90 R+ FA++ L+ + DKE +F +K E G+ +P G Sbjct: 37 DFAWNSQQIQFRKKVIQFAQQSLISDLIKNDKEEIFNRDAWQKCSEFGVHGWPIPARYGG 96 Query: 91 AGLDYLAYSIALEEISRGCASTGVIMSVNNSLYL--GPILKFGSSQQKQQWITPFTNGDK 148 LD L + AL+ + GC G+I ++N ++ P+L FG+ +QK++++ G Sbjct: 97 QELDILTTAYALQGLGYGCKDNGLIFAMNAHIWACEMPLLTFGTEEQKEKYLPLLCRGGW 156 Query: 149 IGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNK 208 I A +EP GSD + TTA+++GD ++LNG K ++TN A ++FA+ D S + Sbjct: 157 IASHAATEPQAGSDIYSLKTTAQKDGDKYILNGYKHYVTNGTIADLFIIFATIDPSLGKE 216 Query: 209 GISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTL 268 G++ F++ TPGL L K K+G+R + L E+C + N LGE G G I ++ Sbjct: 217 GLTTFMIEKDTPGLILSKPISKMGMRTAEVPELRLENCEVSAANRLGEEGTGLAIFNHSM 276 Query: 269 DMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLT 328 + R I + A+G + L+ +++YA + FG + K Q + KL +M L LE+A+ Sbjct: 277 EWERGFILAAAVGTMERLLEQSIRYARSHKQFGQAIGKFQLVANKLVEMKLRLENAKAYL 336 Query: 329 WRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARIT 388 ++ A +K+NK+ E++MA L SEA +AI+I G GY+T ER RDA + Sbjct: 337 YKVAWMKENKQMALLEASMANLYISEAWVQSCLEAIEIHGAYGYLTNTELERELRDAIAS 396 Query: 389 EIYEGTSEIQRLVIAGHL 406 + Y GTSEIQR+VIA L Sbjct: 397 KFYSGTSEIQRVVIAKFL 414 >3NF4-A nrPDB Length = 387 Score = 393 bits (1011), Expect = e-110, Method: Composition-based stats. Identities = 153/374 (40%), Positives = 232/374 (62%), Gaps = 3/374 (0%) Query: 35 PETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLD 94 + L + R+ A+K L PI + +K+ +P +++G GLL++ PEE G G Sbjct: 17 SQEAAELIELTREIADKVLDPIVDRHEKDETYPEGVFEQLGAAGLLSLPQPEEWGGGGQP 76 Query: 95 YLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFAL 154 Y Y LEEI+ AS V +SV+ SL P+L FG+ +QK++W+ +G++IG ++L Sbjct: 77 YEVYLQVLEEIAARWASVAVAVSVH-SLSSHPLLVFGTEEQKKRWLPGMLSGEQIGAYSL 135 Query: 155 SEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFL 214 SEP GSDA A A +V+NG+K+WIT+ +A +FA T ++G+S FL Sbjct: 136 SEPQAGSDAAALRCAATPTDGGYVINGSKSWITHGGKADFYTLFARTGE--GSRGVSCFL 193 Query: 215 VPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIG 274 VP PGL+ GK E+K+G+ A T + +++ RI + +GE G G +IA LD GR+G Sbjct: 194 VPADQPGLSFGKPEEKMGLHAVPTTSAFYDNARIDADRRIGEEGQGLQIAFSALDSGRLG 253 Query: 275 IASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAML 334 IA+ A G+AQA+LD AV YA R AFG + Q + F LADMA A+ +AR AA Sbjct: 254 IAAVATGLAQAALDEAVAYANERTAFGRKIIDHQGLGFLLADMAAAVATARATYLDAARR 313 Query: 335 KDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGT 394 +D +P+++++++AKL A++AA ++ A+Q+ GG+GY + ERY R+A+I +I+EGT Sbjct: 314 RDQGRPYSQQASIAKLTATDAAMKVTTDAVQVFGGVGYTRDYRVERYMREAKIMQIFEGT 373 Query: 395 SEIQRLVIAGHLLR 408 ++IQRLVIA L R Sbjct: 374 NQIQRLVIARGLTR 387 >2Z1Q-A nrPDB Length = 577 Score = 391 bits (1005), Expect = e-109, Method: Composition-based stats. Identities = 150/402 (37%), Positives = 227/402 (56%), Gaps = 22/402 (5%) Query: 25 LHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEH-LFPTSQVKKMGELGLLAMD 83 VY + E+ + + +T R F E+E++P+ +++ ++K GELGLLA+D Sbjct: 19 PERVYTPEDFDESVKEIARTTRTFVEREVLPLLERMEHGELELNVPLMRKAGELGLLAID 78 Query: 84 VPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPF 143 VPEE G L + ++ EE+S G V + S+ P++ FG+ +QK++++ Sbjct: 79 VPEEYGGLDLPKVISTVVAEELS-GSGGFSVTYGAHTSIGTLPLVYFGTEEQKRKYLPKL 137 Query: 144 TNGDKIGCFALSEPGNGSDAGAASTTAR--EEGDSWVLNGTKAWITNSWEASATVVFAST 201 +G+ I + L+EPG+GSDA AA T A E+G ++LNG K WI+N+ A VFA Sbjct: 138 ASGEWIAAYCLTEPGSGSDALAAKTRATLSEDGKHYILNGVKQWISNAGFAHLFTVFAKV 197 Query: 202 DRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGF 261 D + +AFLV TPGL+ G +E K+GI+ASST +I ED ++P EN+LGE G G Sbjct: 198 D----GEHFTAFLVERDTPGLSFGPEEKKMGIKASSTRQVILEDVKVPVENVLGEIGKGH 253 Query: 262 KIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALAL 321 KIA L++GR + + A+G A+ +L+ + +YA R FG P+ + IQ KL +MA + Sbjct: 254 KIAFNVLNVGRYKLGAGAVGGAKRALELSAQYATQRVQFGRPIGRFGLIQQKLGEMASRI 313 Query: 322 ESARLLTWRAAMLKDNK--------------KPFTKESAMAKLAASEAATAISHQAIQIL 367 +A +R L D + + E+++ K+ SE + + +QI Sbjct: 314 YAAESAVYRTVGLIDEALLGKKGPEAVMAGIEEYAVEASIIKVLGSEVLDYVVDEGVQIH 373 Query: 368 GGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRS 409 GG GY E P ER YRDARI I+EGT+EI RL+I G LLR Sbjct: 374 GGYGYSQEYPIERAYRDARINRIFEGTNEINRLLIPGMLLRR 415 >3OWA-A nrPDB Length = 597 Score = 387 bits (995), Expect = e-108, Method: Composition-based stats. Identities = 145/412 (35%), Positives = 220/412 (53%), Gaps = 29/412 (7%) Query: 21 DWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTS--QVKKMGELG 78 D + V+ + H+M+ +T DF E++P + ++H F S +K+ GELG Sbjct: 20 DEITIDQVFTPEDFSSEHKMIAKTTEDFIVNEVLPEL-EYLEQHEFDRSVRLLKEAGELG 78 Query: 79 LLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQ 138 LL DVPEE G GLD ++ ++ E+ SR + + + PI+ FG+ +QK++ Sbjct: 79 LLGADVPEEYGGIGLDKVSSALIAEKFSRA-GGFAITHGAHVGIGSLPIVLFGNEEQKKK 137 Query: 139 WITPFTNGDKIGCFALSEPGNGSDAGAASTTARE--EGDSWVLNGTKAWITNSWEASATV 196 ++ G+K+ +AL+EPG+GSDA A TTAR EG +VLNG K WITNS A + Sbjct: 138 YLPLLATGEKLAAYALTEPGSGSDALGAKTTARLNAEGTHYVLNGEKQWITNSAFADVFI 197 Query: 197 VFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGE 256 V+A D + SAF+V G++ +E K+GI+ SST LI ED +PKENLLGE Sbjct: 198 VYAKID----GEHFSAFIVEKDYAGVSTSPEEKKMGIKCSSTRTLILEDALVPKENLLGE 253 Query: 257 PGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLAD 316 G G IA L++GR + +G A+ +++ + +YA R F P+ + IQ KLA+ Sbjct: 254 IGKGHIIAFNILNIGRYKLGVGTVGSAKRAVEISAQYANQRQQFKQPIARFPLIQEKLAN 313 Query: 317 MALALESARLLTWRAAMLKDNK-------------------KPFTKESAMAKLAASEAAT 357 MA +A +R L +++ + E ++ K+ SE Sbjct: 314 MAAKTYAAESSVYRTVGLFESRMSTLSEEEVKDGKAVAASIAEYAIECSLNKVFGSEVLD 373 Query: 358 AISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRS 409 + +QI GG G++ E ER YRD+RI I+EGT+EI RL++ G LR Sbjct: 374 YTVDEGVQIHGGYGFMAEYEIERMYRDSRINRIFEGTNEINRLIVPGTFLRK 425 >2CX9-A nrPDB Length = 387 Score = 386 bits (992), Expect = e-107, Method: Composition-based stats. Identities = 174/377 (46%), Positives = 236/377 (62%), Gaps = 4/377 (1%) Query: 37 THQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYL 96 + + R+F + E+ P AA+ D+ FP V+K+ E G+ VPE GAGL Sbjct: 10 EERQVLGPFREFLKAEVAPGAAERDRTGAFPWDLVRKLAEFGVFGALVPEAYGGAGLSTR 69 Query: 97 AYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSE 156 ++ +E I+ + + ++ +NSL G IL GS QK+ ++ +G+ +G + L+E Sbjct: 70 LFARMVEAIAYYDGALALTVASHNSLATGHILLAGSEAQKEAFLPKLASGEALGAWGLTE 129 Query: 157 PGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDR----SRQNKGISA 212 PG+GSDA A T A + W LNGTK +IT A VV A TD R+++GISA Sbjct: 130 PGSGSDAAALKTKAEKVEGGWRLNGTKQFITQGSVAGVYVVMARTDPPPSPERKHQGISA 189 Query: 213 FLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGR 272 F P GL +G+KE+KLG+ AS TA LI ED +P+E LLGE G GF ++ LD GR Sbjct: 190 FAFFRPERGLKVGRKEEKLGLTASDTAQLILEDLFVPEEALLGERGKGFYDVLRVLDGGR 249 Query: 273 IGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAA 332 IGIA+ A+G+ QA+LD A+ YA+ R AFG P+ + + + FKLA+ A LE+ARLL +AA Sbjct: 250 IGIAAMAVGLGQAALDYALAYAKGREAFGRPIAEFEGVSFKLAEAATELEAARLLYLKAA 309 Query: 333 MLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYE 392 LKD +PFT E+A AKL ASEAA +AIQILGG GYV + P ERY+RDAR+T I E Sbjct: 310 ELKDAGRPFTLEAAQAKLFASEAAVKACDEAIQILGGYGYVKDYPVERYWRDARLTRIGE 369 Query: 393 GTSEIQRLVIAGHLLRS 409 GTSEI +LVIA LL + Sbjct: 370 GTSEILKLVIARRLLEA 386 >2EBA-A nrPDB Length = 385 Score = 380 bits (976), Expect = e-106, Method: Composition-based stats. Identities = 134/374 (35%), Positives = 194/374 (51%), Gaps = 6/374 (1%) Query: 34 LPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGL 93 L + +++ R F EKE +P +E +FPT + + ELG L +P E GAG+ Sbjct: 11 LTPEEKEVQKAARRFLEKEALPHIRDWWEEGVFPTHLIPRFAELGFLGPTLPPEYGGAGV 70 Query: 94 DYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFA 153 AY + E+ R + +SV +SL + PI +GS +QK++++ G+ +GCF Sbjct: 71 SSAAYGLICYELERVDSGLRSFVSVQSSLVMYPIYAYGSEEQKREFLPKLARGEMVGCFG 130 Query: 154 LSEPGNGSDA-GAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISA 212 L+EP GSD G T AR EGD+WVLNGTK WITN A V++A + + Sbjct: 131 LTEPDGGSDPYGNMKTRARREGDTWVLNGTKMWITNGNLAHLAVIWAK----DEGGEVLG 186 Query: 213 FLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGR 272 FLVP TPG + + K+ +RAS T+ L+ E+ R+P+ L +G K + L R Sbjct: 187 FLVPTDTPGFQAREVKRKMSLRASVTSELVLEEVRVPESLRL-PKALGLKAPLSCLTQAR 245 Query: 273 IGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAA 332 GIA A+G +A + AV +A++R FG PL K Q +Q KLA+M LL WR A Sbjct: 246 FGIAWGAMGALEAVYEEAVAFAKSRSTFGEPLAKKQLVQAKLAEMLAWHTEGLLLAWRLA 305 Query: 333 MLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYE 392 LKD K + ++AK A + A ILGG G E A R+ + YE Sbjct: 306 RLKDEGKLTPAQVSLAKRQNVWKALQAARMARDILGGSGITLEYHAIRHMLNLETVYTYE 365 Query: 393 GTSEIQRLVIAGHL 406 GT ++ LV+ + Sbjct: 366 GTHDVHTLVLGREI 379 >1SIR-A nrPDB Length = 394 Score = 378 bits (972), Expect = e-105, Method: Composition-based stats. Identities = 121/390 (31%), Positives = 192/390 (49%), Gaps = 12/390 (3%) Query: 20 RDWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGL 79 DW+ + + +L ++R T R + ++ L+P ++ +F + +MGELG+ Sbjct: 4 FDWQDPLVLEE--QLTTDEILIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGV 61 Query: 80 LAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQW 139 L + + AG+ +AY + E+ R + MSV +SL + PI +GS +Q+Q++ Sbjct: 62 LGPTI-KGYGCAGVSSVAYGLLARELERVDSGYRSAMSVQSSLVMHPIYAYGSEEQRQKY 120 Query: 140 ITPFTNGDKIGCFALSEPGNGSDAGAASTTAREE--GDSWVLNGTKAWITNSWEASATVV 197 + G+ +GCF L+EP +GSD + T A S+ LNGTK WITNS A VV Sbjct: 121 LPQLAKGELLGCFGLTEPNSGSDPSSMETRAHYNSSNKSYTLNGTKTWITNSPMADLFVV 180 Query: 198 FASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLL-GE 256 +A ++ I FL+ GL+ + + K +RAS+T +I + +P+EN+L G Sbjct: 181 WARC----EDGCIRGFLLEKGMRGLSAPRIQGKFSLRASATGMIIMDGVEVPEENVLPGA 236 Query: 257 PGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLAD 316 +G L+ R GIA LG ++ L A +YA +R FG PL + Q IQ KLAD Sbjct: 237 SSLG--GPFGCLNNARYGIAWGVLGASEFCLHTARQYALDRMQFGVPLARNQLIQKKLAD 294 Query: 317 MALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEM 376 M + + LKD K + ++ K A I+ QA +LGG G E Sbjct: 295 MLTEITLGLHACLQLGRLKDQDKAAPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEY 354 Query: 377 PAERYYRDARITEIYEGTSEIQRLVIAGHL 406 R+ + YEGT +I L++ + Sbjct: 355 HVIRHAMNLEAVNTYEGTHDIHALILGRAI 384 >3SF6-A nrPDB Length = 403 Score = 378 bits (970), Expect = e-105, Method: Composition-based stats. Identities = 130/375 (34%), Positives = 186/375 (49%), Gaps = 10/375 (2%) Query: 34 LPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFP-TSQVKKMGELGLLAMDVPEELSGAG 92 L + +R T R ++ + P A ++ P ++GELGLL M + + AG Sbjct: 30 LSAEEREIRDTVRSVVQRRIKPHIASWYEDGELPARELAVELGELGLLGMHL-KGYGCAG 88 Query: 93 LDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCF 152 + +AY +A E+ G + ++SV SL + I FGS +QK QW+ +G +IGCF Sbjct: 89 MSAVAYGLACLELEAGDSGIRSLVSVQGSLAMYAIHAFGSDEQKDQWLPDMASGHRIGCF 148 Query: 153 ALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISA 212 L+EP +GSD T A GD W+L GTK WITN A VV+A TD +GI Sbjct: 149 GLTEPDHGSDPAGMRTRATRSGDDWILTGTKMWITNGSVADVAVVWARTD-----EGIRG 203 Query: 213 FLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLL-GEPGMGFKIAMQTLDMG 271 F+VP TPG T + K+ +RAS T+ L+ + R+P L G +G ++ L+ Sbjct: 204 FVVPTDTPGFTANTIKSKMSLRASVTSELVLDGVRLPDSARLPGATSLG--APLRCLNEA 261 Query: 272 RIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRA 331 R GI ALG A+ L+ A+ YA +R F P+ Q Q KLADM L LL Sbjct: 262 RFGIVFGALGAARDCLETALAYACSREQFDRPIGGFQLTQQKLADMTLEYGKGFLLALHL 321 Query: 332 AMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIY 391 KD + ++ ++ KL A I+ A +LG G E P R+ + Y Sbjct: 322 GRQKDAGELAPEQVSLGKLNNVREAIEIARTARTVLGASGITGEYPVMRHANNLESVLTY 381 Query: 392 EGTSEIQRLVIAGHL 406 EGTSE+ L+I L Sbjct: 382 EGTSEMHTLIIGQAL 396 >4W9U-A nrPDB Length = 395 Score = 369 bits (948), Expect = e-102, Method: Composition-based stats. Identities = 112/391 (28%), Positives = 183/391 (46%), Gaps = 7/391 (1%) Query: 16 ALRARDWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMG 75 + A W + + +L E +M+R + + FA L+P + E MG Sbjct: 3 SRAAFAWEDPFLLEE--QLTEDERMIRDSAKAFASDVLLPRVEKAYLEETTDPELFHLMG 60 Query: 76 ELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQ 135 + GLL + +PE+ A Y+AY + E+ R + +MSV +SL + PI +GS +Q Sbjct: 61 QAGLLGVTLPEDYGAANASYVAYGLVAREVERIDSGYRSMMSVQSSLVMYPIYAYGSDEQ 120 Query: 136 KQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASAT 195 +++++ +G+ IGCF L+EP GSD T A + + L+G+K WI+NS A Sbjct: 121 RKKYLPGLVSGELIGCFGLTEPDAGSDPAGMKTRAEKIDGGYRLSGSKMWISNSPIADVF 180 Query: 196 VVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLG 255 VV+A + + + I F++ GL+ K KL +RAS T ++ + + ++ +L Sbjct: 181 VVWAKS--AAHDNAIRGFILEKGMKGLSAPKIGGKLSLRASITGEIVMDGVEVSEDAIL- 237 Query: 256 EPGM-GFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKL 314 P + G K L+ R GI+ LG A+ A +Y +R F PL Q Q KL Sbjct: 238 -PNVSGLKGPFGCLNRARYGISWGVLGAAEDCWFRARQYGLDRKQFNKPLAGTQLYQKKL 296 Query: 315 ADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVT 374 ADM + + R L D K + ++ K A I+ QA + GG G Sbjct: 297 ADMQTEIALGIQASLRVGRLFDEGKMAPEMISIVKRNNCGKALDIARQARDMHGGNGIQI 356 Query: 375 EMPAERYYRDARITEIYEGTSEIQRLVIAGH 405 E R+ ++ YEGT ++ L++ Sbjct: 357 EYHVMRHAQNLETVNTYEGTHDVHALILGRA 387 >3SWO-A nrPDB Length = 399 Score = 366 bits (939), Expect = e-101, Method: Composition-based stats. Identities = 128/387 (33%), Positives = 187/387 (48%), Gaps = 14/387 (3%) Query: 27 TVYQSVEL-------PETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGL 79 + Y +EL + + + T R F + L P + P+ K+ G LG+ Sbjct: 12 STYAPLELFDTDRLLDQDERDIAATVRQFVDTRLKPNVEGWFESATLPSELAKEFGNLGV 71 Query: 80 LAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQW 139 L M + + AG + ++Y +A E+ G + +SV SL + I ++GS +QK +W Sbjct: 72 LGMHL-QGYGCAGTNAVSYGLACMELEAGDSGFRSFVSVQGSLSMFSIYRYGSEEQKNEW 130 Query: 140 ITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFA 199 + GD IGCF L+EP GS+ T AR +G W+LNGTK WITN A V+A Sbjct: 131 LPRLAAGDAIGCFGLTEPDFGSNPAGMRTRARRDGSDWILNGTKMWITNGNLADVATVWA 190 Query: 200 STDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGM 259 TD GI FLVP TPG T + KL +RAS T+ L+ ++ R+P L Sbjct: 191 QTD-----DGIRGFLVPTDTPGFTANEIHRKLSLRASVTSELVLDNVRLPASAQL-PLAE 244 Query: 260 GFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMAL 319 G + L+ R GI ALG A+ SL+ + Y ++R F PL+ Q Q KLA+M + Sbjct: 245 GLSAPLSCLNEARFGIVFGALGAARDSLETTIAYTQSREVFDKPLSNYQLTQEKLANMTV 304 Query: 320 ALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAE 379 L LL +KD + ++ ++ KL A AI+ + +LGG G E Sbjct: 305 ELGKGMLLAIHLGRIKDAEGVRPEQISLGKLNNVREAIAIARECRTLLGGSGITLEYSPL 364 Query: 380 RYYRDARITEIYEGTSEIQRLVIAGHL 406 R+ + YEGTSE+ L I L Sbjct: 365 RHANNLESVLTYEGTSEMHLLSIGKAL 391 >3R7K-A nrPDB Length = 403 Score = 364 bits (934), Expect = e-101, Method: Composition-based stats. Identities = 133/397 (33%), Positives = 190/397 (47%), Gaps = 2/397 (0%) Query: 11 GSLGRALRARDWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQ 70 G + D V + L Q R F E+E+ P A+ + P Sbjct: 6 TDAGTTTASEDGAARFVVAPEAWTTPERRALSQMARSFVEREIAPKLAEWEHVGEIPRDL 65 Query: 71 VKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSV-NNSLYLGPILK 129 E+GLL + PEE+ G+G + + ++ E I STGV ++ + + L I Sbjct: 66 HLNAAEVGLLGIGFPEEVGGSGGNAIDSALVTEAILAAGGSTGVCAALFTHGIALPHIAA 125 Query: 130 FGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNS 189 GS ++++ P G IG ++EPG GSD T A EGD++V+NG K +IT+ Sbjct: 126 NGSDALIERYVRPTLAGKMIGSLGVTEPGAGSDVANLRTRAVREGDTYVVNGAKTFITSG 185 Query: 190 WEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIP 249 A T G+S ++ +PG + ++ DK+G R S TA L F D R+P Sbjct: 186 VRADFVTTAVRTG-GPGYGGVSLLVIDKNSPGFEVSRRLDKMGWRCSDTAELSFVDVRVP 244 Query: 250 KENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQN 309 +NL+G GF MQ R+GIA QA A +LD A +A R FG PLT Q Sbjct: 245 ADNLVGAENSGFLQIMQQFQAERLGIAVQAYATAGRALDLAKSWARERETFGRPLTGRQI 304 Query: 310 IQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGG 369 I+ KLA+MA ++ A T + E +MAK A A + ++A+QI GG Sbjct: 305 IRHKLAEMARQVDVACTYTRAVMQRWLAGEDVVAEVSMAKNTAVYACDYVVNEAVQIFGG 364 Query: 370 MGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHL 406 MGY+ E ER+YRD RI I GT+EI VIA + Sbjct: 365 MGYMRESEIERHYRDCRILGIGGGTNEIMNEVIAKRI 401 >2IX5-A nrPDB Length = 436 Score = 364 bits (934), Expect = e-101, Method: Composition-based stats. Identities = 111/373 (29%), Positives = 182/373 (48%), Gaps = 7/373 (1%) Query: 34 LPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGL 93 L Q +R+ R+ EKE+ PI + ++ FP K+G +G+ + + GL Sbjct: 55 LTPEEQAIRKKVRECMEKEVAPIMTEYWEKAEFPFHITPKLGAMGVAGGSI-KGYGCPGL 113 Query: 94 DYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFA 153 A +IA EI+R AS + V++SL + I GS QK++++ + + C+A Sbjct: 114 SITANAIATAEIARVDASCSTFILVHSSLGMLTIALCGSEAQKEKYLPSLAQLNTVACWA 173 Query: 154 LSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAF 213 L+EP NGSDA TTA + W +NG K WI NS A ++FA + Q I+ F Sbjct: 174 LTEPDNGSDASGLGTTATKVEGGWKINGQKRWIGNSTFADLLIIFARNTTTNQ---INGF 230 Query: 214 LVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGM-GFKIAMQTLDMGR 272 +V PGL K +K+G+R +++ ++ +P E+ L PG+ F+ + L + R Sbjct: 231 IVKKDAPGLKATKIPNKIGLRMVQNGDILLQNVFVPDEDRL--PGVNSFQDTSKVLAVSR 288 Query: 273 IGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAA 332 + +A Q +GI+ D +Y + R FGAPL Q Q KL M +++ L+ WR Sbjct: 289 VMVAWQPIGISMGIYDMCHRYLKERKQFGAPLAAFQLNQQKLVQMLGNVQAMFLMGWRLC 348 Query: 333 MLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYE 392 L + + ++++ K S A + ++LGG G + + + + D YE Sbjct: 349 KLYETGQMTPGQASLGKAWISSKARETASLGRELLGGNGILADFLVAKAFCDLEPIYTYE 408 Query: 393 GTSEIQRLVIAGH 405 GT +I LV Sbjct: 409 GTYDINTLVTGRE 421 >3B96-A nrPDB Length = 587 Score = 363 bits (932), Expect = e-101, Method: Composition-based stats. Identities = 135/386 (34%), Positives = 203/386 (52%), Gaps = 13/386 (3%) Query: 29 YQSVELPETHQMLRQTCR---DFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVP 85 Y SV E Q L++ F E+ P A+ D + + + + ELG + VP Sbjct: 22 YPSVLNEEQTQFLKELVEPVSRFFEEVNDP--AKNDALEMVEETTWQGLKELGAFGLQVP 79 Query: 86 EELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTN 145 EL G GL Y+ +E + G+ + + S+ IL FG+ QK++++ + Sbjct: 80 SELGGVGLCNTQYARLVEIVGMHDLGVGITLGAHQSIGFKGILLFGTKAQKEKYLPKLAS 139 Query: 146 GDKIGCFALSEPGNGSDAGAASTTAREE--GDSWVLNGTKAWITNSWEASATVVFASTDR 203 G+ + F L+EP +GSDA + T+A G + LNG+K WI+N A VFA T Sbjct: 140 GETVAAFCLTEPSSGSDAASIRTSAVPSPCGKYYTLNGSKLWISNGGLADIFTVFAKTPV 199 Query: 204 SRQNKG-----ISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPG 258 + G I+AF+V G+T G E K+GI+AS+TA + F+ R+P EN+LGE G Sbjct: 200 TDPATGAVKEKITAFVVERGFGGITHGPPEKKMGIKASNTAEVFFDGVRVPSENVLGEVG 259 Query: 259 MGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMA 318 GFK+AM L+ GR G+A+ G + + AV +A NR FG + IQ KLA M Sbjct: 260 SGFKVAMHILNNGRFGMAAALAGTMRGIIAKAVDHATNRTQFGEKIHNFGLIQEKLARMV 319 Query: 319 LALESARLLTWRAAMLKDNK-KPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMP 377 + + + + D F E+A++K+ SEAA ++ + IQI+GGMG++ E Sbjct: 320 MLQYVTESMAYMVSANMDQGATDFQIEAAISKIFGSEAAWKVTDECIQIMGGMGFMKEPG 379 Query: 378 AERYYRDARITEIYEGTSEIQRLVIA 403 ER RD RI I+EGT++I RL +A Sbjct: 380 VERVLRDLRIFRIFEGTNDILRLFVA 405 >5ZW7-A nrPDB Length = 402 Score = 360 bits (924), Expect = e-100, Method: Composition-based stats. Identities = 103/378 (27%), Positives = 175/378 (46%), Gaps = 2/378 (0%) Query: 31 SVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSG 90 L + + ++ FA L A + + T KK G V + G Sbjct: 2 DFNLSNSQSDIYESAYRFACDVLDQDAQTRISQKILSTELWKKAAAYGFAHGPVSHQFGG 61 Query: 91 AGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLG--PILKFGSSQQKQQWITPFTNGDK 148 + L L ++ +E + +G G+ S+ L P+ +FGSS+ K +++ G Sbjct: 62 SELGALDTALMIEALGKGSRDIGLSFSLCAHLCACVIPLYRFGSSELKDKYLESLVTGKL 121 Query: 149 IGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNK 208 I A +EP GSD TA+ ++LNG K +ITN+ A +++A T+ Sbjct: 122 IAANAATEPDAGSDIYNMQATAQPCEGGYILNGKKIFITNAPIADVFIIYAKTNPDHGFL 181 Query: 209 GISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTL 268 G+SAFL+ TPGL +G+ K + + ++F D IP+ +G G G I ++ Sbjct: 182 GVSAFLIEKGTPGLNVGEVIPKDCLSNCPWSEIVFNDIFIPQSQRIGMEGAGGAIFHDSM 241 Query: 269 DMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLT 328 + +++ +G L+ ++YA+ R FG + + Q++ ++ DM L LE RL+ Sbjct: 242 IWEKGCLSALFVGGLARLLETTLEYAKARQQFGKAIGQFQSVSNRIIDMKLRLEQCRLML 301 Query: 329 WRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARIT 388 +RA D + + AM+KL SE A AIQ GG E+ R+ + + Sbjct: 302 YRACWKHDQGQDAEADIAMSKLLISEYAVQSGLDAIQTFGGAAMDQELGLVRHLLNMIPS 361 Query: 389 EIYEGTSEIQRLVIAGHL 406 I+ GT++IQ+ +IA L Sbjct: 362 RIFSGTNDIQKEIIARKL 379 >6CY8-B nrPDB Length = 380 Score = 358 bits (918), Expect = 3e-99, Method: Composition-based stats. Identities = 120/379 (31%), Positives = 197/379 (51%), Gaps = 8/379 (2%) Query: 32 VELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELS-- 89 E L + F ++ P+ +++ FP +G+ G + +PE+ + Sbjct: 3 FEWTHEQAELFEHALRFGKELSAPL----QEDNGFPRDNWNALGDFGYFGLPIPEKYAKD 58 Query: 90 GAGLDYLAYSIALEEISRGCASTGVIMS--VNNSLYLGPILKFGSSQQKQQWITPFTNGD 147 G+G D L +E + + C TG++ + + PIL+ GS K Q + G Sbjct: 59 GSGFDILTTIKIIEGLGQSCTDTGLLFAGAAHTFACSMPILEHGSETLKHQLLPDLATGR 118 Query: 148 KIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQN 207 KI A+SE GSD +TTA++EGD +VLNG K+++TN A VV+A+T++ Sbjct: 119 KIAANAISEASAGSDISNLATTAQKEGDYYVLNGGKSYVTNGSIADYYVVYATTNKKHGY 178 Query: 208 KGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQT 267 G +AF+VP TPG+++G KLG+R++ + F++C I K+ LG G G +I + Sbjct: 179 LGQTAFVVPRNTPGISVGNDYHKLGLRSAPLNQVFFDNCTIHKDYALGREGQGARIFAAS 238 Query: 268 LDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLL 327 +D R + + +G Q L+ ++YA R +++ Q + ++ADM + LESARL+ Sbjct: 239 MDWERCCLFAIFVGAMQRDLNQCIEYANTRMQGDKTISRFQAVSHRIADMGVRLESARLM 298 Query: 328 TWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARI 387 + AA K TK AM+KLA SEA +I++ G +GY+ E +DA Sbjct: 299 LYYAAWQKSQDVDNTKAVAMSKLAISEAFVQSGIDSIRVHGALGYLDEGRVNNSIKDALG 358 Query: 388 TEIYEGTSEIQRLVIAGHL 406 + ++ GTS+IQR +I L Sbjct: 359 SVLFSGTSDIQRELICNRL 377 >3P4T-A nrPDB Length = 403 Score = 347 bits (890), Expect = 6e-96, Method: Composition-based stats. Identities = 133/378 (35%), Positives = 192/378 (50%), Gaps = 3/378 (0%) Query: 31 SVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSG 90 S+ + LR+T R FAE+E++P A + ++ P +K ELGLL PE+ G Sbjct: 23 SIWTTAEREALRKTVRAFAEREVLPHAHEWERAGEIPRELHRKAAELGLLGAGFPEDAGG 82 Query: 91 AGLDYLAYSIALEEISRGCASTGVIMSVNN-SLYLGPILKFGSSQQKQQWITPFTNGDKI 149 +G D + EE+ + GV S+ + + ++ G + ++ P G+KI Sbjct: 83 SGGDGADPVVICEEMHYAGSPGGVYASLFTCGIAVPHMIASGDQRLIDTYVRPTLRGEKI 142 Query: 150 GCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKG 209 G A++EPG GSD G T A +GD +V+NG K +IT+ A V A T G Sbjct: 143 GALAITEPGGGSDVGHLRTRADLDGDHYVINGAKTYITSGVRADYVVTAARTG-GPGAGG 201 Query: 210 ISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLD 269 +S +V TPG + +K DK+G R+S TA L + D R+P NL+G GF Sbjct: 202 VSLIVVDKGTPGFEVTRKLDKMGWRSSDTAELSYTDVRVPVANLVGSENTGFAQIAAAFV 261 Query: 270 MGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTW 329 R+G+A+QA AQ LD V++ NR FG PL Q +Q LA MA ++ AR+ T Sbjct: 262 AERVGLATQAYAGAQRCLDLTVEWCRNRDTFGRPLISRQAVQNTLAGMARRIDVARVYTR 321 Query: 330 RAAMLKDNKK-PFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARIT 388 + + E AK A EA +++QA+Q+ GGMGY+ E ER YRD RI Sbjct: 322 HVVERQLAGETNLIAEVCFAKNTAVEAGEWVANQAVQLFGGMGYMAESEVERQYRDMRIL 381 Query: 389 EIYEGTSEIQRLVIAGHL 406 I GT+EI + A L Sbjct: 382 GIGGGTTEILTSLAAKTL 399 >5AHS-A nrPDB Length = 401 Score = 344 bits (884), Expect = 3e-95, Method: Composition-based stats. Identities = 124/381 (32%), Positives = 195/381 (51%), Gaps = 8/381 (2%) Query: 33 ELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAG 92 EL + L+ R+ A+ A Q D +P V ++ + G + M +P + G G Sbjct: 3 ELTPEQRTLQTQARELAQSVFASTAVQTDLTEQYPWDNVAQLRDAGFMGMMLPTSVGGRG 62 Query: 93 LDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCF 152 L L I +EE+++ CA+ G I +N +G I K+GS +Q + GDK Sbjct: 63 LSTLDTVIVIEEMAKACATMGRITVDSNLGAIGAITKYGSEEQIKLAADLVLAGDK-PAI 121 Query: 153 ALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISA 212 +SEP GS A +T A + GD ++LNG K WIT + ++FA +GI A Sbjct: 122 CISEPNAGSAASEMTTRADKNGDHYILNGEKYWITGGGVSKLHLIFARVFDDGVEQGIGA 181 Query: 213 FLVPMPT---PGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPG---MGFKIAMQ 266 F+ + GL +G++ +G+R +L F D +I K ++ P GF M Sbjct: 182 FITVLDDHGPEGLKVGRRLYAMGVRGIPETHLEFHDLKIHKSMMITFPDGLKRGFAALMS 241 Query: 267 TLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARL 326 + R+G + ALGIAQ + + V Y + R FG PL + Q +Q+ +ADM++ LE+ARL Sbjct: 242 AYNAQRVGAGAVALGIAQCAFEEGVAYLKRREQFGRPLAEFQGLQWMVADMSVQLEAARL 301 Query: 327 LTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDAR 386 + R+A + P ++A AK+ A+E A +++ A+Q G GY P ER+ RDAR Sbjct: 302 M-LRSAAVSGETFPDINKAAQAKIFAAETANKVTNDALQFFGSSGYGRHNPMERHVRDAR 360 Query: 387 ITEIYEGTSEIQRLVIAGHLL 407 + I GT++I R +A +L Sbjct: 361 MFTIAGGTAQILRTQVASKIL 381 >5IDU-A nrPDB Length = 410 Score = 338 bits (868), Expect = 2e-93, Method: Composition-based stats. Identities = 141/399 (35%), Positives = 209/399 (52%), Gaps = 8/399 (2%) Query: 17 LRARDWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGE 76 + A + H H+ L +A + L Q D V+ +GE Sbjct: 9 MLAANLIDPHGALAWPFFEARHRELAAGIEAWATQHLA--CVQHDDTDTTCRKLVRALGE 66 Query: 77 LGLLAMDVP-EELSGAG--LDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSS 133 G L V + G G +D A + E ++ +++ L G I G+ Sbjct: 67 AGWLKYGVGGAQYGGHGDTIDTRAVCLLRETLANHDGLADFALAMQ-GLGSGAITLAGTH 125 Query: 134 QQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEAS 193 +QK +++ + G+ I FALSEP GSD A S AR EGD +V++G K WI+N A Sbjct: 126 EQKIRYLPRVSKGEAIAAFALSEPDAGSDVAAMSLQARAEGDCYVIDGDKTWISNGGIAD 185 Query: 194 ATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENL 253 VVFA T + +GISAF+V TPGL + ++ D + A L F+ R+P+ + Sbjct: 186 FYVVFARTGEAPGARGISAFIVDADTPGLQIAERIDVIAPH--PLARLHFDSARVPRSQM 243 Query: 254 LGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFK 313 LG PG GFKIAM+TLD+ R +A+ +LG A+ +L + A +R FG L Q Q K Sbjct: 244 LGAPGEGFKIAMRTLDVFRTSVAAASLGFARRALQEGLARAASRKMFGQTLGDFQLTQTK 303 Query: 314 LADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYV 373 LA MAL ++S+ LL +RAA L+D + T+E+AMAK ASE A + A+Q+ GGMG Sbjct: 304 LAQMALTIDSSALLVYRAAWLRDQGENVTREAAMAKWHASEGAQQVIDAAVQLWGGMGVQ 363 Query: 374 TEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRSYRS 412 + ER YR+ R IYEG +E+Q+L++ LL+++ + Sbjct: 364 SGTTVERLYREIRALRIYEGATEVQQLIVGRDLLKAHAA 402 >5JSC-A nrPDB Length = 410 Score = 313 bits (801), Expect = 1e-85, Method: Composition-based stats. Identities = 135/395 (34%), Positives = 202/395 (51%), Gaps = 8/395 (2%) Query: 17 LRARDWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGE 76 + A LH+ H+ L + L + V+++G Sbjct: 9 MSANTELDLHSALAWPFFEPRHRELAAGIEAWCRANLA--HEDHEDVDATCRRLVRELGA 66 Query: 77 LGLLAMDVPEELSGAGLDYLAY---SIALEEISRGCASTGVIMSVNNSLYLGPILKFGSS 133 G L V G D + + E +++ +++ L G I G+ Sbjct: 67 AGWLKYGVGGVAYGGHGDTIDTRAVCLLRETLAKHSGLADFALAMQ-GLGSGAISLGGTH 125 Query: 134 QQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEAS 193 +QK +++ NG I FALSEP GSD A + +ARE+GD++VL+G K WI+N A Sbjct: 126 EQKTRYLPRVANGTAIAAFALSEPEAGSDVAAMTLSAREDGDAYVLDGDKTWISNGGIAD 185 Query: 194 ATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENL 253 VVFA T + +GISAF+V TPGL + ++ D + A L F R+P+ + Sbjct: 186 FYVVFARTGEAPGARGISAFVVDADTPGLEIAERIDVIAPH--PLARLHFAGARVPRSQM 243 Query: 254 LGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFK 313 LG PG GFK+AM+TLD+ R +A+ +LG A+ ++ V A +R FG L Q Q K Sbjct: 244 LGAPGEGFKLAMRTLDIFRTSVAAASLGFARHAMAEGVARAASRKMFGQTLGDFQLTQAK 303 Query: 314 LADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYV 373 LA MAL ++S+ LL +RAA L+D + T+E+AMAK ASE A + A+Q+ GGMG Sbjct: 304 LAQMALTIDSSALLVYRAAWLRDQGENVTREAAMAKWHASEGAQQVIDAAVQLYGGMGVQ 363 Query: 374 TEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLR 408 + E YR+ R IYEG +E+Q+L++ LL+ Sbjct: 364 SGTAVEMLYREIRALRIYEGATEVQQLIVGRDLLK 398 >4RM7-A nrPDB Length = 391 Score = 308 bits (789), Expect = 3e-84, Method: Composition-based stats. Identities = 113/385 (29%), Positives = 176/385 (45%), Gaps = 10/385 (2%) Query: 33 ELPETHQMLRQTCRDFAEKELVPIA-AQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGA 91 L Q L R++ EK P + ++ K+ P VK +L V + Sbjct: 7 GLSRDEQRLLNHVREYGEKYFTPASISKWRKDQGLPDEVVKAFVDLDFNGFGVIHRRNHR 66 Query: 92 GLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPIL-KFGSSQQKQQWITPFT-NGDKI 149 D A + +EE+SR + + N L IL F SS Q + T + G Sbjct: 67 TYDLFAQVLVIEELSRISGAC---LPFQNDLLQLQILEAFASSAQTSPFRTEYQDTGRLS 123 Query: 150 GCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFA--STDRSRQN 207 A+SEP GSD + T EGD+ V+NGTK ++ N A A +V A T + Sbjct: 124 YALAISEPEAGSDTRSMRTHVTREGDTLVMNGTKMFVNNGEYAPALLVSAYDKTGDDGEP 183 Query: 208 KGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQT 267 + S ++VP G+ E K+G A + F++ + + L GF Sbjct: 184 E-FSFWMVPRSAAGI-YAYPEQKIGQSMLPFATVRFDNVEVKESWRLKGSSKGFSQLYSL 241 Query: 268 LDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLL 327 L+ GR+ + ALG AQA+++ AV +A R AFG + LQ +Q KL +M + L + R L Sbjct: 242 LEYGRVFTCAAALGEAQAAMEDAVAWARGREAFGQRIADLQQVQMKLTEMEVKLTNMRNL 301 Query: 328 TWRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARI 387 + AA D + A+ K +AAT ++ A+QILGG GY+ E ++D R Sbjct: 302 VYGAAREYDRGEHKRLSVALMKYYVPKAATEVASDAMQILGGRGYIQENRVSSIWQDCRG 361 Query: 388 TEIYEGTSEIQRLVIAGHLLRSYRS 412 + +GT E+ ++ A +L Y++ Sbjct: 362 YQFADGTDEVMVVIAAPLILEQYKA 386 >2WBI-A nrPDB Length = 428 Score = 299 bits (765), Expect = 2e-81, Method: Composition-based stats. Identities = 105/409 (25%), Positives = 182/409 (44%), Gaps = 27/409 (6%) Query: 25 LHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDK---EHLFPTSQV---------K 72 + T Q Q + + F ++ ++P ++ + ++ + K Sbjct: 14 IDTTGQLFVQTRKGQEVLIKVKHFMKQHILPAEKEVTEFYVQNENSVDKWGKPLVIDKLK 73 Query: 73 KMGEL-GLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVI-MSVNNSLYLGPILKF 130 +M ++ GL + +P +GL ++ Y++ EE + + V ++ + + + Sbjct: 74 EMAKVEGLWNLFLPA---VSGLSHVDYALIAEETGKCFFAPDVFNCQAPDTGNMEVLHLY 130 Query: 131 GSSQQKQQWITPFTNGDKIGCFALSEPG-NGSDAGAASTTAREEGDSWVLNGTKAWITNS 189 GS +QK+QW+ P G+ CF ++EP SDA + + + DS+V+NG K W + + Sbjct: 131 GSEEQKKQWLEPLLQGNITSCFCMTEPDVASSDATNIECSIQRDEDSYVINGKKWWSSGA 190 Query: 190 WEASA--TVVFASTDRSR--QNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTA---NLI 242 +V T + ++K S LVPM TPG+ + + G + + Sbjct: 191 GNPKCKIAIVLGRTQNTSLSRHKQHSMILVPMNTPGVKIIRPLSVFGYTDNFHGGHFEIH 250 Query: 243 FEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGA 302 F R+P NL+ G GF+I+ L GRI + +G+A+ +L + A R AF Sbjct: 251 FNQVRVPATNLILGEGRGFEISQGRLGPGRIHHCMRTVGLAERALQIMCERATQRIAFKK 310 Query: 303 PLTKLQNIQFKLADMALALESARLLTWRAAMLKD--NKKPFTKESAMAKLAASEAATAIS 360 L + + +A+ +A+E RLLT +AA D KE AM K+AA A + I Sbjct: 311 KLYAHEVVAHWIAESRIAIEKIRLLTLKAAHSMDTLGSAGAKKEIAMIKVAAPRAVSKIV 370 Query: 361 HQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRS 409 AIQ+ GG G + P Y R+ + +G E+ IA LR Sbjct: 371 DWAIQVCGGAGVSQDYPLANMYAITRVLRLADGPDEVHLSAIATMELRD 419 >4HR3-A nrPDB Length = 415 Score = 297 bits (760), Expect = 6e-81, Method: Composition-based stats. Identities = 116/400 (29%), Positives = 181/400 (45%), Gaps = 27/400 (6%) Query: 40 MLRQTCRDFAEKELVP------------------IAAQLDKEHLFPTSQVKKMGELGLLA 81 L R+F + E++P A+L S K GL Sbjct: 15 ELIAAVREFIDAEVMPVERAVLAHHDELLGARAGTTAELWHVPPELDSLKAKARAAGLWN 74 Query: 82 MDVPEELSGAGLDYLAYSIALEEISRGC-ASTGVIMSVNNSLYLGPILKFGSSQQKQQWI 140 + +P+ G GL Y+ E++ R A T + +S + + ++GS +QK+ W+ Sbjct: 75 LFLPDPELGGGLSNSEYAPLAEQMGRSLFAPTVFNCNAPDSGNMEVLHRYGSQEQKEVWL 134 Query: 141 TPFTNGDKIGCFALSEPG-NGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVV-- 197 P GD F ++EP SDA + TA EGD V+NG K W T V+ Sbjct: 135 EPLLEGDIRSAFCMTEPDVASSDATNMAATAVVEGDEVVINGRKWWSTGVGHPDCKVIIF 194 Query: 198 FASTDR-SRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTAN--LIFEDCRIPKENLL 254 TD + + S LVPM TPG+T+ + +G + + F++ R+P + + Sbjct: 195 MGLTDPNAHRYARHSMVLVPMDTPGITVERMLPTMGFYDEPGGHGVVSFDNVRLPADAFI 254 Query: 255 GEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKL 314 PG GF+IA L GR+ A + +G+A+ +L+ A + +R AFG PL L + ++ Sbjct: 255 AGPGKGFEIAQGRLGPGRVHHAMRLIGLAEVALEHACRRGLDRTAFGKPLVNLGGNRERI 314 Query: 315 ADMALALESARLLTWRAAMLKDNKKPFTKESAMA--KLAASEAATAISHQAIQILGGMGY 372 AD +A+ RLL AA L D SA++ K+AA A + AIQI GG G Sbjct: 315 ADARIAINQTRLLVLHAAWLLDTVGIMGALSAVSEIKVAAPNMAQQVIDMAIQIHGGGGL 374 Query: 373 VTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRSYRS 412 + P + +AR + +G E+ R V+A L Y + Sbjct: 375 SNDFPLAAAWVNARALRLADGPDEVHRGVVARIELAKYAN 414 >1R2J-A nrPDB Length = 366 Score = 260 bits (665), Expect = 7e-70, Method: Composition-based stats. Identities = 101/355 (28%), Positives = 165/355 (46%), Gaps = 8/355 (2%) Query: 56 IAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVI 115 AA+ D P + ++G GLL +V E G GL + C+S + Sbjct: 15 RAAEWDTSGELPRDLLVRLGADGLLCAEVAAEHGGLGLGSRENGEFTAHVGSLCSSLRSV 74 Query: 116 MSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGD 175 M+ + + + G + Q+ ++ T+G K+ SE GSD A T R +GD Sbjct: 75 MTSQ-GMAAWTVQRLGDAGQRATFLKELTSG-KLAAVGFSERQAGSDLSAMRTRVRLDGD 132 Query: 176 SWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRA 235 + V++G K W T + A VVF +++ + +VP TPG+ + + G RA Sbjct: 133 TAVVDGHKVWTTAAAYADHLVVFGL----QEDGSGAVVVVPADTPGVRVERVPKPSGCRA 188 Query: 236 SSTANLIFEDCRIPKENLLGEPGMGFKIAMQ-TLDMGRIGIASQALGIAQASLDCAVKYA 294 + A+L + R+P +L G + + +L GR +A +GI +A AV +A Sbjct: 189 AGHADLHLDQVRVPAGAVLAGSGASLPMLVAASLAYGRKSVAWGCVGILRACRTAAVAHA 248 Query: 295 ENRHAFGAPLTKLQNIQFKLADMALALE-SARLLTWRAAMLKDNKKPFTKESAMAKLAAS 353 R FG PL Q + +AD+ A + +AR+ + + + + +AK A+ Sbjct: 249 RTREQFGRPLGDHQLVAGHIADLWTAEQIAARVCEYASDHWDEGSPEMVPATILAKHVAA 308 Query: 354 EAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLR 408 E A A + A Q+L G ER YRDA++ EI EG+SE+ R+++A H L Sbjct: 309 ERAAAGAATAAQVLASAGAREGHVVERAYRDAKLMEIIEGSSEMCRVMLAQHALA 363 >4X28-A nrPDB Length = 400 Score = 258 bits (660), Expect = 3e-69, Method: Composition-based stats. Identities = 94/396 (23%), Positives = 161/396 (40%), Gaps = 31/396 (7%) Query: 35 PETHQMLRQTCRDFAEKELVPIAAQLDKE-------HLFPTSQVKKMGELGLLAMDVPEE 87 + LR+ R + + P + + +MG G LA+ P+E Sbjct: 6 TPQQEELRRELRSYFATLMTPERREALSSVQGEYGVGNVYRETIAQMGRDGWLALGWPKE 65 Query: 88 LSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGD 147 G G + I +E + A + + I+ +G+ +QK+ ++ GD Sbjct: 66 YGGQGRSAMDQLIFTDEAAIAGAPVPF---LTINSVAPTIMAYGTDEQKRFFLPRIAAGD 122 Query: 148 KIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDR---- 203 SEPG G+D TTA +GD +V+NG K W + A + T+ Sbjct: 123 LHFSIGYSEPGAGTDLANLRTTAVRDGDDYVVNGQKMWTSLIQYADYVWLAVRTNPESSG 182 Query: 204 SRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKI 263 +++++GIS +VP G + G S+T + D R+P N +GE G+K+ Sbjct: 183 AKKHRGISVLIVPTTAEGFSWTPVHTMAGPDTSAT---YYSDVRVPVANRVGEENAGWKL 239 Query: 264 AMQTLDMGRIGIASQALGIAQASLDCAVKYAE-NRHAFGAPLTKLQNIQFKLADMALALE 322 L+ R+ + S A L ++A+ + A G L + +Q LA + E Sbjct: 240 VTNQLNHERVALVSPAPIF--GCLREVREWAQNTKDAGGTRLIDSEWVQLNLARVHAKAE 297 Query: 323 SARLLTWRAAMLKDNKK---PFTKESAMAKLAASEAATAISHQAIQILG--------GMG 371 +L+ W A + K P +++ AK+ +E AT +++LG G Sbjct: 298 VLKLINWELASSQSGPKDAGPSPADASAAKVFGTELATEAYRLLMEVLGTAATLRQNSPG 357 Query: 372 YVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLL 407 + ER +R I GT+E+QR +I L Sbjct: 358 ALLRGRVERMHRACLILTFGGGTNEVQRDIIGMVAL 393 >5GJ7-A nrPDB Length = 398 Score = 257 bits (656), Expect = 8e-69, Method: Composition-based stats. Identities = 90/375 (24%), Positives = 161/375 (42%), Gaps = 19/375 (5%) Query: 25 LHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDV 84 ++ +Y LP + + RD A+ A + D+ FP ++ + G + V Sbjct: 4 MYDIYGEAALPADVRERLRITRDLAQA-FHERAPEHDRAGDFPFENIEDLKASGYVRWTV 62 Query: 85 PEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNS--LYLGPILKFGSSQQKQQWITP 142 P E G GL + E +++G ST + + + L+L F + + Sbjct: 63 PVEYGGLGLSLEEMLMHQEVLAKGDGSTALAIGWHVGILLHLRETGAFPDELFRMVCESV 122 Query: 143 FTNGDKIGCFALSEPGNGSDAGA--ASTTAREEGDSWVLNGTKAWITNSWEASATVVFAS 200 G I A +EP GS + TTA + + + G K + T S + +V A+ Sbjct: 123 VKEGALINSCA-TEPATGSPSRGGKPETTAVKVPGGYRITGRKTFSTLSPALTWIMVTAT 181 Query: 201 TDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMG 260 + FLV + + + D LG+RA+ + +++ +D +P+E ++ G Sbjct: 182 V---ADEDVVGQFLVRKED--VEIVETWDTLGMRATGSHDIVLKDVFVPEERVIVIQRPG 236 Query: 261 FKIAMQTLDMG-RIGIASQALGIAQASLDCAVKYAENRH--AFGAPLTKLQNIQFKLADM 317 + + G + I + LGIA A+ D A++YA P+ ++ +++ KL +M Sbjct: 237 VQAERRPDGSGWLLHIPACYLGIALAARDFALEYAATYRPNTLPHPIAEVPHVEQKLGEM 296 Query: 318 ALALESARLLTWRAAMLKDNKKPFTK-----ESAMAKLAASEAATAISHQAIQILGGMGY 372 L L +AR L + A D P + + K A+ AA + A++++GG Sbjct: 297 ELKLLAARTLLYDLARRFDAASPEERVKLQPQFGAVKTLATNAANQVVDLAMRVVGGRSL 356 Query: 373 VTEMPAERYYRDARI 387 +P ERYYRD R Sbjct: 357 SRALPLERYYRDVRA 371 >5XDD-A nrPDB Length = 414 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 88/399 (22%), Positives = 163/399 (40%), Gaps = 38/399 (9%) Query: 22 WRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLA 81 R +H S + E H+ L + A K + ++ P ++ + GLL Sbjct: 1 MRTIHA--NSSAVREDHRAL-DVATELA-KTFRVTVRERERAGGTPKAERDAIRRSGLLT 56 Query: 82 MDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWIT 141 + + +E G G + A+ EI+ AS G + + S + + F S +QK +W Sbjct: 57 LLISKERGGLGESWPTVYEAIAEIASADASLGHLFGYHFSNFAY-VDLFASPEQKARWYP 115 Query: 142 PFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFAST 201 A SE + T +G S+ +NGTKA+ + S +A +VFA T Sbjct: 116 QAVRERWFLGNASSENNAHVLDWRVTATPLPDG-SYEINGTKAFCSGSADADRLLVFAVT 174 Query: 202 DRSRQNKG-ISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGM- 259 R G I A L+P G+ + D LG+R + + ++ F + + LLG PG Sbjct: 175 SRDPNGDGRIVAALIPSDRAGVQVNGDWDSLGMRQTDSGSVTFSGVVVYPDELLGTPGQV 234 Query: 260 ------GFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHA-------------- 299 G K ++ T + ++ LGIA+ +L+ A Y+ + Sbjct: 235 TDAFASGSKPSLWT-PITQLIFTHLYLGIARGALEEAAHYSRSHSRPFTLAGVEKATEDP 293 Query: 300 -----FGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASE 354 +G +LQ + ++AL ++ L R + + + + A AK+ A+ Sbjct: 294 YVLAIYGEFAAQLQVAEAGAREVALRVQE---LWERNHVTPEQRGQLMVQVASAKIVATR 350 Query: 355 AATAISHQAIQILGGM-GYVTEMPAERYYRDARITEIYE 392 ++ + + +G + +R++RDAR +++ Sbjct: 351 LVIELTSRLYEAMGARAAASRQFGFDRFWRDARTHTLHD 389 >3M9V-A nrPDB Length = 439 Score = 231 bits (589), Expect = 4e-61, Method: Composition-based stats. Identities = 96/355 (27%), Positives = 162/355 (45%), Gaps = 22/355 (6%) Query: 52 ELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYL-AYSIALEEISRGCA 110 + AA+ D++ FPT + + GL+ VP EL G G+D L ++AL ++R A Sbjct: 37 RIRSTAAEHDRDGTFPTDTFDALRKDGLMGATVPAELGGLGVDRLYDVAVALLAVARADA 96 Query: 111 STGVIMSVNNS--LYLGPILKFGSSQQK---QQWITPFTNGDKIGCFALSEPGNGSDAGA 165 ST + + + S L LG + G + + ++ + GD + C + D Sbjct: 97 STALALHMQLSRGLTLGYEWRHGDERARTLAERILRGMVAGDAVVCSGIK------DHHT 150 Query: 166 ASTTAREEG-DSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTL 224 A TT R +G W+L+G K ++ + + V+ A TD + +++ +V TPG T+ Sbjct: 151 AVTTLRPDGAGGWLLSGRKTLVSMAPVGTHFVINARTDGTDGPPRLASPVVTRDTPGFTV 210 Query: 225 GKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFK--IAMQTLDMGRIGIASQALGI 282 D LG+RAS T +++F+DC IP +++L +G + + + + + +G+ Sbjct: 211 LDNWDGLGMRASGTVDIVFDDCPIPADHVLMRDPVGARNDAVLAGQTVSSVSVLGVYVGV 270 Query: 283 AQASLDCAVKYAENRHA--FGAPLTKLQNIQFKL----ADMALALESARLLTWRAAMLKD 336 AQA+ D AV E R A LT + I +L A AL +A L+ + D Sbjct: 271 AQAAYDTAVAALERRPEPPQAAALTLVAEIDSRLYALRATAGSALTAADALSADLSGDMD 330 Query: 337 N-KKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEI 390 + + AKLA + A I + ++GG Y P R RD + Sbjct: 331 ERGRQMMRHFQCAKLAVNRLAPEIVSDCLSLVGGASYTAGHPLARLLRDVQAGRF 385 >2C12-A nrPDB Length = 439 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 93/416 (22%), Positives = 175/416 (42%), Gaps = 46/416 (11%) Query: 31 SVELPETHQMLRQTCRDFAEKELVPIAAQL----DKEHLFP--TSQVKKMGELGLLAMDV 84 +L + R+ + FA L +A+ D+ F ++ GL+ V Sbjct: 3 DFKLSPSQLEARRHAQAFANTVLTKASAEYSTQKDQLSRFQATRPFYREAVRHGLIKAQV 62 Query: 85 PEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFT 144 P L G + SI LEE+ +T + + V +L L P++ S +++++ PF Sbjct: 63 PIPLGGTMESLVHESIILEELFAVEPATSITI-VATALGLMPVILCDSPSLQEKFLKPFI 121 Query: 145 NGD--KIGCFALSEPGNGSD-----AGAASTTAREEGDSWVLNGTKAWITNSWE-----A 192 +G+ + SEP ++ TTAR+ G+ WV++G K W +NS A Sbjct: 122 SGEGEPLASLMHSEPNGTANWLQKGGPGLQTTARKVGNEWVISGEKLWPSNSGGWDYKGA 181 Query: 193 SATVVFASTDRSRQNKG------ISAFLVPMPTPGLTLGKKEDKL---------GIRASS 237 V + V + T K+D G +S Sbjct: 182 DLACVVCRVSDDPSKPQDPNVDPATQIAVLLVTRETIANNKKDAYQILGEPELAGHITTS 241 Query: 238 TANLIFEDCRIPKENLLGEPGMGFKIAMQT-LDMGRIGIASQALGIAQASLDCAVKYAEN 296 + F + +P ENLL PG+ + ++T M + + A+G A+A+ + A+ +A++ Sbjct: 242 GPHTRFTEFHVPHENLLCTPGLKAQGLVETAFAMSAALVGAMAIGTARAAFEEALVFAKS 301 Query: 297 RHAFGAP-LTKLQNIQFKLADMALALESARLLTWRAAM-LKDNKKPFTKESAMA---KLA 351 G+ + + Q++ KL D + LE++RLL W+A L+D + + MA K+ Sbjct: 302 DTRGGSKHIIEHQSVADKLIDCKIRLETSRLLVWKAVTTLEDEALEWKVKLEMAMQTKIY 361 Query: 352 ASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTS------EIQRLV 401 ++ A A++ +G Y +M R + +++G + ++QR++ Sbjct: 362 TTDVAVECVIDAMKAVGMKSYAKDMSFPRLLNEVMCYPLFDGGNIGLRRRQMQRVM 417 >4ZYJ-A nrPDB Length = 425 Score = 222 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 89/363 (24%), Positives = 155/363 (42%), Gaps = 27/363 (7%) Query: 47 DFAEKELVPIAAQ---LDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYL-AYSIAL 102 D E+ L + A+ D+E P +M + G+L VPE+L G G+ L ++AL Sbjct: 51 DLLERYLPALEAESRDNDREATLPVHLFDRMRKEGVLGATVPEDLGGLGVHSLHDVALAL 110 Query: 103 EEISRGCASTGVIMSVNNS--LYLGPILKFGSSQQK---QQWITPFTNGDKIGCFALSEP 157 I+ A + + + S L L + G+ + + + G+ + C A+ Sbjct: 111 ARIAGRDAGVALALHMQFSRGLTLDFEWRHGAPSTRPLAEDLLRQMGAGEAVICGAVK-- 168 Query: 158 GNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPM 217 D + R S+ LNG K ++ + A+ VV + + ++A +V Sbjct: 169 ----DVRGTTVLTRATDGSYRLNGRKTLVSMAGIATHYVVSTRLEEAGAPVRLAAPVVAR 224 Query: 218 PTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLL--GEPGMGFKIAMQTLDMGRIGI 275 TPGLT+ D +G+R+S + +++F+ C + ++ +L GEPG+ A+ + I + Sbjct: 225 TTPGLTVLDNWDGMGMRSSGSVDIVFDGCPVDRDRVLPRGEPGVRDDAALAGQTVSSIAM 284 Query: 276 ASQALGIAQASLDCAVKYAENRHAFGAPLT---KLQNIQFKLADMALALESARLLTWRAA 332 +GIA+A+ A+ E R GAP + I +L + A+ SA R A Sbjct: 285 LGIYVGIAEAARRIAL--TELRRRGGAPAGVRTTVAEIDARLFALHTAVASALTTADRLA 342 Query: 333 -----MLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARI 387 L + AKL + + + + ++GG GY P R YRD R Sbjct: 343 DDLSGDLAARGRAMMTPFQYAKLLVNRHSVGVVDDCLMLVGGAGYSNSHPLARLYRDVRA 402 Query: 388 TEI 390 Sbjct: 403 GGF 405 >4JEK-A nrPDB Length = 453 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 88/399 (22%), Positives = 156/399 (39%), Gaps = 39/399 (9%) Query: 32 VELPETHQMLR----------QTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLA 81 + L Q +R R AEK A + D+ T++ + + GLL+ Sbjct: 37 MTLSPEKQHVRPRDAADNDPVAVARGLAEKWRA-TAVERDRAGGSATAEREDLRASGLLS 95 Query: 82 MDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWIT 141 + VP E G G D+ + EI+ S G + + + I GS +Q++ T Sbjct: 96 LLVPREYGGWGADWPTAIEVVREIAAADGSLGHLFGYHLT-NAPMIELIGSQEQEEHLYT 154 Query: 142 PFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFAST 201 + A SE + S T E+G +VLNGTK + + + + VF Sbjct: 155 QIAQNNWWTGNASSENNSHVLDWKVSATPTEDGG-YVLNGTKHFCSGAKGSDLLFVFGVV 213 Query: 202 -DRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMG 260 D S Q I A +P G+T +G+R + + + F + ++ + +LG P Sbjct: 214 QDDSPQQGAIIAAAIPTSRAGVTPNDDWAAIGMRQTDSGSTDFHNVKVEPDEVLGAPNA- 272 Query: 261 FKIAMQTLDMG-------RIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQF- 312 F +A + G ++ A+ LGIA +LD A +Y + P Q + Sbjct: 273 FVLAFIQSERGSLFAPIAQLIFANVYLGIAHGALDAAREYTRTQARPWTPAGIQQATEDP 332 Query: 313 ----KLADMALALESAR----------LLTWRA--AMLKDNKKPFTKESAMAKLAASEAA 356 + +AL+ A W A+ +++ + + K A+ AA Sbjct: 333 YTIRSYGEFTIALQGADAAAREAAHLLQTVWDKGDALTPEDRGELMVKVSGVKALATNAA 392 Query: 357 TAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTS 395 IS +++G G +R++R+ R +++ S Sbjct: 393 LNISSGVFEVIGARGTHPRYGFDRFWRNVRTHSLHDPVS 431 >3MXL-A nrPDB Length = 395 Score = 217 bits (553), Expect = 7e-57, Method: Composition-based stats. Identities = 91/357 (25%), Positives = 145/357 (40%), Gaps = 26/357 (7%) Query: 52 ELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYL-AYSIALEEISRGCA 110 + AA D+ FP ++ +LGL+ VP EL G GL L + AL ++ A Sbjct: 26 RISAEAADRDRTGTFPVEAFEQFAKLGLMGATVPAELGGLGLTRLYDVATALMRLAEADA 85 Query: 111 STGVIMSVNNS--LYLGPILKFGSSQQK---QQWITPFTNGDKIGCFALSEPGNGSDAGA 165 ST + V S L L + G+ + ++ + G+ C AL DA Sbjct: 86 STALAWHVQLSRGLTLTYEWQHGTPPVRAMAERLLRAMAEGEAAVCGALK------DAPG 139 Query: 166 ASTTAREEG-DSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTL 224 T +G W+L+G K ++ + A+ V A + ++ +V PGLT+ Sbjct: 140 VVTELHSDGAGGWLLSGRKVLVSMAPIATHFFVHAQRRDDDGSVFLAVPVVHRDAPGLTV 199 Query: 225 GKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFK--IAMQTLDMGRIGIASQALGI 282 D LG+RAS T ++F+ C + + LL +G + + + I + GI Sbjct: 200 LDNWDGLGMRASGTLEVVFDRCPVRADELLERGPVGARRDAVLAGQTVSSITMLGIYAGI 259 Query: 283 AQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALE---SARLLTWRAAML----- 334 AQA+ D AV + R G P + + L AL A L AA + Sbjct: 260 AQAARDIAVGFCAGR--GGEPRAGARALVAGLDTRLYALRTTVGAALTNADAASVDLSGD 317 Query: 335 -KDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEI 390 + + AK+ +E A A+ + ++GG+ Y P R YRD R Sbjct: 318 PDERGRRMMTPFQYAKMTVNELAPAVVDDCLSLVGGLAYTAGHPLSRLYRDVRAGGF 374 >5EZ3-A nrPDB Length = 573 Score = 215 bits (547), Expect = 4e-56, Method: Composition-based stats. Identities = 90/334 (26%), Positives = 148/334 (44%), Gaps = 35/334 (10%) Query: 98 YSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQ---------QKQQWITPFTNGDK 148 Y A E C T S+ + + K S QK + Sbjct: 152 YLTAQLEAGHLCPLTMTSASLAALMASPEVYKQWSPAVLSRKYDFSQKPAFRKQGVT--- 208 Query: 149 IGCFALSEPGNGSDAGAASTTAREE-GDSWVLNGTKAWITNSWEASATVVFASTDRSRQN 207 ++E G+D A +T A G +W L G K W ++ + A + A T Sbjct: 209 -LGMGMTEKQGGTDVRANATRAEPAIGGAWRLTGHK-WFMSAPMSDAFLTLAQT-----K 261 Query: 208 KGISAFLVPM-----PTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFK 262 +G+S FL+P + G + +DKLG R+++++ + F+ ++G PG G K Sbjct: 262 EGLSCFLLPRLGEKGESNGFFFQRLKDKLGNRSNASSEVEFDGA---LGQMIGSPGEGVK 318 Query: 263 IAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALE 322 M + + R+ A + G+ ++ L AV ++ +RH FG PL + +Q LADMAL + Sbjct: 319 TIMDMVTLTRLDCAVASAGLMRSGLAEAVHHSRHRHVFGKPLVEQPLMQRVLADMALDVA 378 Query: 323 SARLLTWRAAMLKDNKKPFTKESAMA-------KLAASEAATAISHQAIQILGGMGYVTE 375 A L+ R A D E+A A K + A A+ ++A++ LGG GY+ + Sbjct: 379 GATALSMRLARAFDMAASDRAEAAFARSMTPVVKYWVCKIAPALLYEAMECLGGNGYIED 438 Query: 376 MPAERYYRDARITEIYEGTSEIQRLVIAGHLLRS 409 R YR+A + I+EG+ + L +A L R+ Sbjct: 439 GNLARAYREAPVNAIWEGSGNVMALDVARVLSRA 472 >3MKH-A nrPDB Length = 438 Score = 214 bits (545), Expect = 6e-56, Method: Composition-based stats. Identities = 98/412 (23%), Positives = 157/412 (38%), Gaps = 60/412 (14%) Query: 31 SVELPETHQMLRQTCRDFAEKELVP-IAAQLDKEHLFP------TSQVKKMGELGLLAMD 83 L + + Q R A L+P L P G+L Sbjct: 4 DFHLSASQKGTYQAARSLARNLLMPARQTYLQHPPNSPLRFQSTQPTYAAAVSAGILKGQ 63 Query: 84 VPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPF 143 + G G + +I +EE S + + L L PI Q +++ PF Sbjct: 64 ISPAHGGTGGTLIESAILVEECYSVEPSAALTI-FATGLGLTPINLAAGP-QHAEFLAPF 121 Query: 144 TNGD--KIGCFALSEPGNGSDA-----GAASTTAREEGDSWVLNGTKAWITNSWEASA-- 194 +G+ + SEPG ++A TTAR EGD WV+NG K W TN Sbjct: 122 LSGEGSPLASLVFSEPGGVANALEKGAPGFQTTARLEGDEWVINGEKMWATNCAGWDFKG 181 Query: 195 --------------------------TVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKE 228 ++ D R +G L + TPG T Sbjct: 182 CDLACVVCRDATTPLEEGQDPENKVMIILVTRADLDRNGEGSFEVLRHVATPGHT----- 236 Query: 229 DKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLD 288 + S ++ + + R+P +N+L G G K+A D + + + +G+ +A+ D Sbjct: 237 ------SVSGPHVRYTNVRVPTKNVLCPAGQGAKVAFGAFDGSAVLVGAMGVGLMRAAFD 290 Query: 289 CAVKYAENRHAFGA-PLTKLQNIQFKLADMALALESARLLTWRAAMLKDNK---KPFTKE 344 A+K+A+ + GA PL + Q L+ + + E+AR LTW+AA +N +E Sbjct: 291 AALKFAKEDNRGGAVPLLERQAFADLLSGVKIQTEAARALTWKAAHAMENGPGDYDARRE 350 Query: 345 SAM-AKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTS 395 A+ AK+ SEAA I +G Y + P A + I++G + Sbjct: 351 LALAAKVFCSEAAVKACTDVINAVGISAYDLQRPFSDLLNTAVVLPIFDGGN 402 >4X28-D nrPDB Length = 373 Score = 211 bits (538), Expect = 4e-55, Method: Composition-based stats. Identities = 99/390 (25%), Positives = 157/390 (40%), Gaps = 37/390 (9%) Query: 31 SVELPETHQMLRQTCRDFAEKELVP-IAAQLDK-EHLFPTSQVKKMGELGLLAMDVPEEL 88 E Q L + P +LDK E F +K+ + G+L+ PE L Sbjct: 2 DFTTTEAAQDLGGLVDTIVDAVCTPEHQRELDKLEQRFDRELWRKLIDAGILSSAAPESL 61 Query: 89 SGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDK 148 G G L L + A+ + SV L G + +FGS + +Q W +GD+ Sbjct: 62 GGDGFGVLEQVAVLVALGHQLAAVPYLESV--VLAAGALARFGSPELQQGWGVSAVSGDR 119 Query: 149 IGCFALS-EPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQN 207 I AL E G G A G + L GT+ + A A +V A TD Sbjct: 120 ILTVALDGEMGEG------PVQAAGTGHGYRLTGTRTQVGYGPVADAFLVPAETD----- 168 Query: 208 KGISAFLVPMPTPGLTLGKK-EDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQ 266 G + FLV PG+ + LG S +L ++ +G G +A+ Sbjct: 169 SGAAVFLVAAGDPGVAVTALATTGLG----SVGHLELNGAKVDAARRVG----GTDVAVW 220 Query: 267 TLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARL 326 + + + LG+ + L +YA R F P+ Q + +LAD + ++ RL Sbjct: 221 LGTLSTLSRTAFQLGVLERGLQMTAEYARTREQFDRPIGSFQAVGQRLADGYIDVKGLRL 280 Query: 327 LTWRAAML--------KDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPA 378 +AA ++ +P + A A A+EA ++H + + GG+G T+ P Sbjct: 281 TLTQAAWRVAEDSLASRECPQPADIDVATAGFWAAEAGHRVAHTIVHVHGGVGVDTDHPV 340 Query: 379 ERYYRDARITEIYEG--TSEIQRLVIAGHL 406 RY+ A+ TE G T +++R I L Sbjct: 341 HRYFLAAKQTEFALGGATGQLRR--IGREL 368 >5YS9-A nrPDB Length = 708 Score = 210 bits (535), Expect = 9e-55, Method: Composition-based stats. Identities = 84/432 (19%), Positives = 161/432 (37%), Gaps = 67/432 (15%) Query: 36 ETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDY 95 E M+ + + ++ ++ D P Q+++ + A+ D Sbjct: 50 ENVTMIERLMTELERDPVLNVSGDYD----MPKEQLRETAVARIAALS-----GHWKKDT 100 Query: 96 LAYSIALEEI-SRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDK--IGCF 152 ++ ++ T + + V+ L++G I G+ +Q W+ K GCF Sbjct: 101 EKEALLRSQLHGIVDMGTRIRLGVHTGLFMGAIRGSGTKEQYDYWVRKGAADVKGFYGCF 160 Query: 153 ALSEPGNGSDAGAASTTAR--EEGDSWVLNG-----TKAWITNSWE-ASATVVFASTDRS 204 A++E G+GS+ TTA ++ D +++N TK WI + A+ T FA Sbjct: 161 AMTELGHGSNVAGLETTATYIQDTDEFIINTPNTGATKWWIGGAAHSATHTACFARLLVD 220 Query: 205 RQNKGISAFLVPMPT-------PGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGE- 256 ++ G+ F+V + PG+ LG K+G A + F + RIP++N+L + Sbjct: 221 GKDYGVKIFVVQLRDVSSHSLMPGIALGDIGKKMGRDAIDNGWIQFTNVRIPRQNMLMKY 280 Query: 257 ---PGMG-------FKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFG----- 301 G ++ L GR+ + + + ++Q + A++YA R FG Sbjct: 281 AKVSSTGKVSQPPLAQLTYGALIGGRVTMIADSFFVSQRFITIALRYACVRRQFGTTPGQ 340 Query: 302 --APLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFT----------------- 342 + Q +L + + ++ ++ + D Sbjct: 341 PETKIIDYPYHQRRLLPLLAFTYAMKMAADQSQIQYDQTTDLLQTIDPKDKGALGKAIVD 400 Query: 343 -----KESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEI 397 SA K + I Q Q GG GY + Y D + +EG + + Sbjct: 401 LKELFASSAGLKAFTTWTCANIIDQCRQACGGHGYSGYNGFGQAYADWVVQCTWEGDNNV 460 Query: 398 QRLVIAGHLLRS 409 L + L++S Sbjct: 461 LCLSMGRGLIQS 472 >3U33-A nrPDB Length = 541 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 89/337 (26%), Positives = 145/337 (43%), Gaps = 36/337 (10%) Query: 99 SIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTN----------GDK 148 + A + G + + + P+L Q W TP + G K Sbjct: 116 ARAARFMLHAQVEAGSLCPITMTFAATPLLLQMLPAPFQDWTTPLLSDRYDSHLLPGGQK 175 Query: 149 IG---CFALSEPGNGSDAGAASTTA-REEGDSWVLNGTKAWITNSWEASATVVFASTDRS 204 G ++E GSD + +T A R E S+ L G K + + ++ A +V A T Sbjct: 176 RGLLIGMGMTEKQGGSDVMSNTTRAERLEDGSYRLVGHKWFFS-VPQSDAHLVLAQT--- 231 Query: 205 RQNKGISAFLVPMPTP-----GLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGM 259 G+S F VP P + L + +DKLG R++++ + F+D LLG G Sbjct: 232 --AGGLSCFFVPRFLPDGQRNAIRLERLKDKLGNRSNASCEVEFQDA---IGWLLGLEGE 286 Query: 260 GFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMAL 319 G ++ ++ M R A + + + + A+ +A RH FG PL + ++ L+ MAL Sbjct: 287 GIRLILKMGGMTRFDCALGSHAMMRRAFSLAIYHAHQRHVFGNPLIQQPLMRHVLSRMAL 346 Query: 320 ALESARLLTWRAAMLKDNKKPFTKESAMAKLAASEAATAIS-------HQAIQILGGMGY 372 LE L +R A D + KE+ A+L A I +A+++LGG+GY Sbjct: 347 QLEGQTALLFRLARAWDRRADA-KEALWARLFTPAAKFVICKRGMPFVAEAMEVLGGIGY 405 Query: 373 VTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRS 409 E R YR+ + I+EG+ I L + L + Sbjct: 406 CEESELPRLYREMPVNSIWEGSGNIMCLDVLRVLNKQ 442 >5Y9D-A nrPDB Length = 709 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 80/364 (21%), Positives = 143/364 (39%), Gaps = 60/364 (16%) Query: 106 SRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITP--FTNGDKIGCFALSEPGNGSDA 163 ST +S++N+L++G I G+ +Q + W+ GCFA++E G+GS+ Sbjct: 118 GMVDMSTRTRLSIHNNLFIGSIRGSGTPEQFKYWVKKGAVAVKQFYGCFAMTELGHGSNL 177 Query: 164 GAASTTAR--EEGDSWVLNG-----TKAWITNSWE-ASATVVFASTDRSRQNKGISAFLV 215 TTA ++ D +++N TK WI + ++ V FA ++ G F+V Sbjct: 178 KGLETTATYDQDSDQFIINTPHIGATKWWIGGAAHTSTHCVCFAKLIVHGKDYGTRNFVV 237 Query: 216 PMPTP-------GLTLGKKEDKLGIRASSTANLIFEDCRIPKENLL------GEPGMGFK 262 P+ G+++G K+G + F + RIP++N+L + G+ K Sbjct: 238 PLRNVHDHSLKVGVSIGDIGKKMGRDGVDNGWIQFTNVRIPRQNMLMRYAKVSDTGVVTK 297 Query: 263 IAMQTLDM-----GRIGIASQALGIAQASLDCAVKYAENRHAFG-------APLTKLQNI 310 A+ L GR+ + + + +++ L A++YA R FG + Sbjct: 298 PALDQLTYGALIRGRVSMIADSFHVSKRFLTIALRYACVRRQFGTSGDTKETKIIDYPYH 357 Query: 311 QFKLA-------DMALALESA---------RLLTW---------RAAMLKDNKKPFTKES 345 Q +L M + + A R+L + K S Sbjct: 358 QRRLLPLLAYCYAMKMGADEAQKTWIETTDRILALNPNDPAQKNDLEKAVTDTKELFAAS 417 Query: 346 AMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGH 405 A K + I + Q GG GY + Y D + +EG + + L + Sbjct: 418 AGMKAFTTWGCAKIIDECRQACGGHGYSGYNGFGQGYADWVVQCTWEGDNNVLCLSMGRG 477 Query: 406 LLRS 409 L++S Sbjct: 478 LVQS 481 >4XVX-A nrPDB Length = 389 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 76/359 (21%), Positives = 152/359 (42%), Gaps = 10/359 (2%) Query: 50 EKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGC 109 ++ +V A+ + + FP ++ +G G+ + + + AL +++ Sbjct: 22 DERVVAWTAEAEAQERFPRQLIEHLGVCGVFDAKWATDARPDVGKLVELAFALGQLA--S 79 Query: 110 ASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTT 169 A GV +S+++S + + +FG S + G + C SE GSD T Sbjct: 80 AGIGVGVSLHDS-AIAILRRFGKSDYLRDICDQAIRGAAVLCIGASEESGGSDLQIVETE 138 Query: 170 AREEGDSWVLNGTKAWITNSWEASATVVFAS-TDRSRQNKGISAFLVPMPTPGLTLGKKE 228 R + + G K +++ S A +V A D ++ + +V +P +++ Sbjct: 139 IRSRDGGFEVRGVKKFVSLSPIADHIMVVARSVDHDPTSRHGNVAVVAVPAAQVSVQTPY 198 Query: 229 DKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLD 288 K+G TA + D +P + L+ G G L R+ IA Q Q ++ Sbjct: 199 RKVGAGPLDTAAVCI-DTWVPADALVARAGTGLAAISWGLAHERMSIAGQIAASCQRAIG 257 Query: 289 CAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMA 348 + +R FG L + Q ++ ++AD+ ++ LL + + + + + +A Sbjct: 258 ITLARMMSRRQFGQTLFEHQALRLRMADLQARVD---LLRYALHGIAEQGRLELRTAAAV 314 Query: 349 KLAASEAATAISHQAIQILGGMGYV-TEMPAERYYRDARITEIYEGTSEI-QRLVIAGH 405 K+ A+ + + + I GG GY+ E +++RD ++ + GT E+ LV AG Sbjct: 315 KVTAARLGEEVISECMHIFGGAGYLVDETTLGKWWRDMKLARVGGGTDEVLWELVAAGM 373 >4Y9J-A nrPDB Length = 593 Score = 199 bits (505), Expect = 3e-51, Method: Composition-based stats. Identities = 79/325 (24%), Positives = 138/325 (42%), Gaps = 30/325 (9%) Query: 106 SRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFA----LSEPGNGS 161 S G S + M+ L + +G + + + + D + ++E GS Sbjct: 138 SAGLVSCPMAMTDGAVKTLTSLNLYGKHKLATEAVDRLRSRDPSKAWTSGQWMTEKKGGS 197 Query: 162 D-AGAASTTARE-EGDSWVLNGTKAWITNSWEASATVVFASTDRSRQN-----KGISAFL 214 D AG T A + + D++ L+G K W +++ +A + A S N +G+S FL Sbjct: 198 DVAGGCDTYAVQIDKDTYRLHGYK-WFSSAVDADVALTLARIVDSDGNALEGSRGLSLFL 256 Query: 215 VPMPTP-----GLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEPGMGFKIAMQTLD 269 + + G+ + + ++KLG + TA L+ + +G+ G G L+ Sbjct: 257 LKIRDESGNLNGIQMVRLKNKLGTKQLPTAELLLDGA---IAERIGDQGRGVAGISNMLN 313 Query: 270 MGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTW 329 + RI A +LG + + A Y+ R FG +K LA M + + LL + Sbjct: 314 ITRIHNAVASLGYMRRIISLARDYSTKRVVFGQTQSKWPLHTTTLAKMEVDTRGSMLLLF 373 Query: 330 RAAM---LKDNKKPFTKESAM-------AKLAASEAATAISHQAIQILGGMGYVTEMPAE 379 AA L + K E+ M KL A + A + + I+ GG GY+ + Sbjct: 374 EAARLLGLSEAGKSSDVEAMMLRLITPVLKLYAGKQAVPMVSEGIECFGGQGYMEDTGLP 433 Query: 380 RYYRDARITEIYEGTSEIQRLVIAG 404 RDA++T I+EGT+ + L + Sbjct: 434 TLLRDAQVTPIWEGTTNVLSLDVLR 458 >2RFQ-A nrPDB Length = 394 Score = 181 bits (459), Expect = 5e-46, Method: Composition-based stats. Identities = 71/380 (18%), Positives = 144/380 (37%), Gaps = 49/380 (12%) Query: 53 LVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCAST 112 L A + + P +K + E G + PE+ G D + + A+ +I+ C ST Sbjct: 23 LRERAQETEDLRRIPDDSMKALQETGFFRLLQPEQWGGYQADPVLFYSAVRKIASACGST 82 Query: 113 GVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTA-- 170 G + S+ ++ + F Q+ W GN +D +S+ A Sbjct: 83 GWVSSI-IGVHNWHLALFSQQAQEDVW------------------GNDTDVRISSSYAPM 123 Query: 171 ---REEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKK 227 + + +NG AW + AS V+ + + +FL+P + Sbjct: 124 GAGQVVDGGYTVNGAWAWSSGCDHASWAVLGGPVIKDGRPVDFVSFLIPRED--YRIDDV 181 Query: 228 EDKLGIRASSTANLIFEDCRIPKENLLG--------EPGMGFKIA-MQTLDMGRIG---I 275 + +G+R + + ++ ED +P +L PG+ A + + G I I Sbjct: 182 WNVVGLRGTGSNTVVVEDVFVPTHRVLSFKAMSNLTAPGLERNTAPVYKMPWGTIHPTTI 241 Query: 276 ASQALGIAQASLDCAVKYA--ENRHAF-GAPLTKLQNIQFKLADMALALESA-RLLTWRA 331 ++ +G+A + D V++ R AF G + ++A+ + +++A R L+ Sbjct: 242 SAPIVGMAYGAYDAHVEHQGKRVRAAFAGEKAKDDPFAKVRIAEASSDIDAAWRQLSGNV 301 Query: 332 AMLKD---NKKPFTKESAMA----KLAASEAATAISHQAIQILGGMGYVTEMPAERYYRD 384 A + E + ++ A+ A + + + G P +R++RD Sbjct: 302 ADEYALLVAGEEVPFELRLRARRDQVRATGRAISSIDKLFESSGATALANGTPLQRFWRD 361 Query: 385 ARITEIYEGTSEIQRLVIAG 404 A ++ + V+ G Sbjct: 362 AHAGRVHAANDPERAYVMYG 381 >1W07-A nrPDB Length = 659 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 67/344 (19%), Positives = 135/344 (39%), Gaps = 49/344 (14%) Query: 114 VIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREE 173 + ++ +++ I G+ +Q+++W++ IGC+A +E G+GS+ TTA + Sbjct: 97 AYVDLHWGMFVPAIKGQGTEEQQKKWLSLANKMQIIGCYAQTELGHGSNVQGLETTATLD 156 Query: 174 G--DSWVLNGTKAWITNSW------EASATVVFASTDRSRQNKGISAFLVPM-------P 218 D +V++ + W ++ VV+A + ++ GI F+V + P Sbjct: 157 PKTDEFVIHTPTQTASKWWPGGLGKVSTHAVVYARLITNGKDYGIHGFIVQLRSLEDHSP 216 Query: 219 TPGLTLGKKEDKLG---IRASSTANLIFEDCRIPKENLLGE------------PGMGFKI 263 P +T+G K+G + L+F+ RIP++ +L + ++ Sbjct: 217 LPNITVGDIGTKMGNGAYNSMDNGFLMFDHVRIPRDQMLMRLSKVTREGEYVPSDVPKQL 276 Query: 264 AMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGA-------PLTKLQNIQFKLAD 316 T+ R I + A ++ A +Y+ R FGA + + Q +L Sbjct: 277 VYGTMVYVRQTIVADASNALSRAVCIATRYSAVRRQFGAHNGGIETQVIDYKTQQNRLFP 336 Query: 317 MALALESAR--------LLTWRAAMLKDNKKPFTKES----AMAKLAASEAATAISHQAI 364 + + + R L T L + E+ A K + A + Sbjct: 337 LLASAYAFRFVGEWLKWLYTDVTERLAASDFATLPEAHACTAGLKSLTTTATADGIEECR 396 Query: 365 QILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLR 408 ++ GG GY+ + YEG + + +L +A L++ Sbjct: 397 KLCGGHGYLWCSGLPELFAVYVPACTYEGDNVVLQLQVARFLMK 440 >2FON-A nrPDB Length = 683 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 68/344 (19%), Positives = 129/344 (37%), Gaps = 49/344 (14%) Query: 114 VIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAR-- 171 ++ +++ I G+ +Q+++W+ IGC+A +E G+GS+ TTA Sbjct: 116 AFTDLHWGMFIPAIKGQGTDKQQEKWLPLAYKMQIIGCYAQTELGHGSNVQGLETTATFD 175 Query: 172 EEGDSWVLNGTKAWITNSW------EASATVVFASTDRSRQNKGISAFLV-------PMP 218 + D +V++ + W ++ VV+A ++ G++ F+V P Sbjct: 176 PQTDEFVIHSPTLTSSKWWPGGLGKVSTHAVVYARLITDGKDYGVNGFIVQLRSLEDHKP 235 Query: 219 TPGLTLGKKEDKLG---IRASSTANLIFEDCRIPKENLLGEPGMGFK------------I 263 PG+T+G K G + L F+ RIP++ +L K + Sbjct: 236 LPGVTVGDIGMKFGNGAYNSMDNGVLSFDHVRIPRDQMLMRVSQVTKEGKYVQSDIPRQL 295 Query: 264 AMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFG-------APLTKLQNIQFKLAD 316 T+ R I + A ++ A +Y+ R FG + + Q +L Sbjct: 296 LYGTMVYVRQSIVADASLAMSRAVCIATRYSAVRRQFGSQNGGQETQVIDYKTQQNRLFP 355 Query: 317 MALALESAR--------LLTWRAAMLKDNKKPFTKES----AMAKLAASEAATAISHQAI 364 + + + R L T L N E+ A K + A + Sbjct: 356 LLASAYAFRFVGEWLKWLYTDVTQRLAANDFSTLPEAHACTAGLKSLTTSATADGIEECR 415 Query: 365 QILGGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLR 408 ++ GG GY+ + YEG + + +L +A L++ Sbjct: 416 KLCGGHGYLCSSGLPELFAVYVPACTYEGDNVVLQLQVARFLMK 459 >1IS2-A nrPDB Length = 661 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 83/390 (21%), Positives = 138/390 (35%), Gaps = 67/390 (17%) Query: 69 SQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPIL 128 + VKKM E G+ PEE+ + RG + ++ ++L +L Sbjct: 69 TMVKKMREYGI---SDPEEIMWFKNS----------VHRGHPEP---LDLHLGMFLPTLL 112 Query: 129 KFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEG--DSWVLNGT---- 182 +++Q++++ P N + G +A +E G+G+ TTA + ++LN Sbjct: 113 HQATAEQQERFFMPAWNLEITGTYAQTEMGHGTHLRGLETTATYDPKTQEFILNSPTVTS 172 Query: 183 -KAWITN-SWEASATVVFASTDRSRQNKGISAFLVP-------MPTPGLTLGKKEDKLGI 233 K W ++ +V A + G+ AF+VP P PG+T+G K G Sbjct: 173 IKWWPGGLGKTSNHAIVLAQLITQGECYGLHAFVVPIREIGTHKPLPGITVGDIGPKFGY 232 Query: 234 RASSTANLIFEDCRIPKENLLG------EPGMGFKIAMQTLDMGR--------IGIASQA 279 L ++ RIP+EN+L G K L G +G A+Q+ Sbjct: 233 EEMDNGYLKMDNYRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGNAAQS 292 Query: 280 LGIAQASLDCAVKYAENRHA----FGAP---LTKLQNIQFK----LADMALALESARLL- 327 L + A++Y+ R P + Q Q+K LA R + Sbjct: 293 L---SKACTIAIRYSAVRRQSEIKQSEPEPQILDFQTQQYKLFPLLATAYAFHFVGRYMK 349 Query: 328 --TWRAAMLKDNKKPFTKE-----SAMAKLAASEAATAISHQAIQILGGMGYVTEMPAER 380 R +A K + A A + GG GY Sbjct: 350 ETYLRINESIGQGDLSELPELHALTAGLKAFTTWTANAGIEECRMACGGHGYSHSSGIPN 409 Query: 381 YYRDARITEIYEGTSEIQRLVIAGHLLRSY 410 Y +EG + + L A L++ Y Sbjct: 410 IYVTFTPACTFEGENTVMMLQTARFLMKIY 439 >5K3G-A nrPDB Length = 684 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 72/342 (21%), Positives = 124/342 (36%), Gaps = 45/342 (13%) Query: 113 GVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTARE 172 G M+++ +++ + S +Q+ +W+ + IG +A +E G+G++ TTA Sbjct: 110 GNPMALHGVMFIPALNAQASDEQQAKWLIRALRREIIGTYAQTEMGHGTNLQNLETTATY 169 Query: 173 E--GDSWVLNGT-----KAWITN-SWEASATVVFASTDRSRQNKGISAFLVP-------M 217 + +VL+ K W N ++ VV A +N G F+VP Sbjct: 170 DIGTQEFVLHTPKITALKWWPGNLGKSSNYAVVVAHMYIKGKNFGPHTFMVPLRDEKTHK 229 Query: 218 PTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGE----PGMG-------FKIAMQ 266 P PG+T+G K+ L F + RIP+ NLL G KI Sbjct: 230 PLPGITIGDIGPKMAYNIVDNGFLGFNNYRIPRTNLLMRHTKVEADGTYIKPPHAKINYS 289 Query: 267 TLDMGRIGIASQALGIAQASLDCAVKYAENRHAF-------GAPLTKLQNIQFKL----A 315 + R + + + +L+ A +Y+ R + + Q Q +L A Sbjct: 290 AMVHVRSYMLTGQAIMLSYALNIATRYSAVRRQGQIDKNEPEVKVLEYQTQQHRLFPFIA 349 Query: 316 DMA----LALESARLLTWRAAMLKDNKKPFTKES----AMAKLAASEAATAISHQAIQIL 367 E+ +L +K + + K + QA Sbjct: 350 RAYAFQFAGAETVKLYERVLKEMKSGNVSLMADLHALTSGLKSVVTHQTGEGIEQARMAC 409 Query: 368 GGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRS 409 GG GY Y A YEG + + L +A +L++S Sbjct: 410 GGHGYSMASYISEIYGVAIGGCTYEGENMVMLLQLARYLVKS 451 >3AFF-A nrPDB Length = 394 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 66/374 (17%), Positives = 135/374 (36%), Gaps = 39/374 (10%) Query: 52 ELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCAS 111 E+ A + P VK + ++G + P++ G D + A ++ C S Sbjct: 22 EIRDRAQATEDLRRLPDETVKALDDVGFFTLLQPQQWGGLQCDPALFFEATRRLASVCGS 81 Query: 112 TGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTAR 171 TG + S+ ++ + F Q++ W + +A G G Sbjct: 82 TGWVSSI-VGVHNWHLALFDQRAQEEVWGED-PSTRISSSYA--PMGAG----------V 127 Query: 172 EEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKL 231 +++NG+ W + AS T V + + +FL+P + + Sbjct: 128 VVDGGYLVNGSWNWSSGCDHASWTFVGGPVIKDGRPVDFGSFLIPRSE--YEIKDVWYVV 185 Query: 232 GIRASSTANLIFEDCRIPKENLLGEPGMGFKIA---------MQTLDMGRIG---IASQA 279 G+R + + L+ +D +P+ L M A + + G + I++ Sbjct: 186 GLRGTGSNTLVVKDVFVPRHRFLSYKAMNDHTAGGLATNSAPVYKMPWGTMHPTTISAPI 245 Query: 280 LGIAQASLDCAVKYA--ENRHAF-GAPLTKLQNIQFKLADMALALESA-RLL-------T 328 +G+A + V++ R AF G + ++A+ A +++A R L Sbjct: 246 VGMAYGAYAAHVEHQGKRVRAAFAGEKAKDDPFAKVRIAEAASDIDAAWRQLIGNVSDEY 305 Query: 329 WRAAMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDARIT 388 A K+ + ++ A+ + A + + G E P +R++RDA Sbjct: 306 ALLAAGKEIPFELRARARRDQVRATGRSIASIDRLFEASGATALSNEAPIQRFWRDAHAG 365 Query: 389 EIYEGTSEIQRLVI 402 ++ + VI Sbjct: 366 RVHAANDPERAYVI 379 >5K3J-A nrPDB Length = 674 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 68/342 (19%), Positives = 117/342 (34%), Gaps = 45/342 (13%) Query: 113 GVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAASTTARE 172 G +++++L++ + S +Q+++W+ + IGC+A +E G+GS+ TTA Sbjct: 108 GHPFALHDALFIPTLQSQASDEQQEKWLERARRREIIGCYAQTELGHGSNLRNLETTAVY 167 Query: 173 E--GDSWVLNGTKAWITNSWE------ASATVVFASTDRSRQNKGISAFLVPMPTP---- 220 + +VL+ W + +V A R N G F+V + Sbjct: 168 DIASQEFVLHTPTTTALKWWPGALGKSCNYALVVAELIIKRNNYGPHFFMVQLRDEKTHI 227 Query: 221 ---GLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGE----PGMG-------FKIAMQ 266 G+T+G K+ A+ L + R+P+ NLL G KI Sbjct: 228 PLKGVTVGDIGPKMNFNAADNGYLGLNNLRVPRTNLLMRHCKVEADGTYVKPPHAKIGYS 287 Query: 267 TLDMGRIGIASQALGIAQASLDCAVKYAENRHAF-------GAPLTKLQNIQFKLADMAL 319 + R +A + +L A +Y+ R + Q Q +L Sbjct: 288 GMVKIRSQMAMEQGLFLAHALTIAARYSAVRRQGHLDDKQVEVKVLDYQTQQHRLFPSLA 347 Query: 320 ALESARLLTWRAAMLKDN---KKPFTKESAMA---------KLAASEAATAISHQAIQIL 367 + + L S MA K + QA Sbjct: 348 RAYAFIFTGFETIHLYSQLLKDVDMGNTSGMADLHALTSGLKSVVAHETGEGIEQARMAC 407 Query: 368 GGMGYVTEMPAERYYRDARITEIYEGTSEIQRLVIAGHLLRS 409 GG GY Y A Y G + + L +A +L++S Sbjct: 408 GGHGYSMASYISVVYGIAIGGCTYAGENMVMLLQLARYLVKS 449 >2JBS-A nrPDB Length = 422 Score = 121 bits (305), Expect = 4e-28, Method: Composition-based stats. Identities = 65/382 (17%), Positives = 130/382 (34%), Gaps = 44/382 (11%) Query: 52 ELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCAS 111 ++ A ++ P +K + E+GL P+ G + ++ + ++ CA Sbjct: 50 QIAKNAESAEQLRRVPDENIKLLKEIGLHRAFQPKVYGGLEMSLPDFANCIVTLAGACAG 109 Query: 112 TGVIMSVNNSLYLGPILKFGSSQQKQQWI--TPFTNGDKIGCFALSEPGNGSDAGAASTT 169 T S+ + I F Q + W+ T I F E Sbjct: 110 TAWAFSL-LCTHSHQIAMFSKQLQDEIWLKDPDATASSSIAPFGKVE------------- 155 Query: 170 AREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKED 229 E +LNG W + A +V + + NK S ++P + Sbjct: 156 --EVEGGIILNGDYGWSSGCDHAEYAIVGFNRFDADGNKIYSFGVIPRSD--YEIVDNWY 211 Query: 230 KLGIRASSTANLIFEDCRIPKEN------LLGEPGMGF------KIAMQTL-DMGRIGIA 276 I++S + L + IP+ ++ GF KI G + Sbjct: 212 AQAIKSSGSKMLKLVNVFIPEYRISKAKDMMEGKSAGFGLYPDSKIFYTPYRPYFASGFS 271 Query: 277 SQALGIAQASLDCAVKYAENRHA--FGAPLTKLQNIQFKLADMALALESARLL---TWRA 331 + +LGIA+ ++ + NR GA + ++A+ + +AR L TW Sbjct: 272 AVSLGIAERMIEAFKEKQRNRVRAYTGANVGLATPALMRIAESTHQVAAARALLEKTWED 331 Query: 332 AMLKDNKKPFTKESAMA-----KLAASEAATAISHQAIQILGGMGYVTEMPAERYYRDAR 386 + + + +A + A + + + G ++ +R +RDA Sbjct: 332 HRIHGLNHQYPNKETLAFWRTNQAYAVKMCIEAVDRLMAAAGATSFMDNSELQRLFRDAH 391 Query: 387 ITEIYEGTS-EIQRLVIAGHLL 407 +T + T ++ ++ L+ Sbjct: 392 MTGAHAYTDYDVCAQILGRELM 413 >5LVW-A nrPDB Length = 413 Score = 106 bits (266), Expect = 1e-23, Method: Composition-based stats. Identities = 74/386 (19%), Positives = 134/386 (34%), Gaps = 40/386 (10%) Query: 23 RRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAM 82 R H E E L + F A+ ++E P + V+ + + L + Sbjct: 13 RGSHMTDIRSETAELRAELVERVHKFG-PVFADGVAEGERERRLPDATVRAIDQSQLAML 71 Query: 83 DVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITP 142 + G D S + +S C ST +++ N L KF + + + Sbjct: 72 WTAKSYGGLETDVRTMSEVAKVLSHYCPSTSWVVNNVNGSNLLA-SKFPRAALDEVFGD- 129 Query: 143 FTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFAS-T 201 G K+ AA+ TA + L G+ + T ++ A Sbjct: 130 -APGAKLAS-----------VFAAAGTAVRTPGGYRLTGSWPYGTGILHDDWAILVAREV 177 Query: 202 DRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLIFEDCRIPKENLLGEP---- 257 D + G + LVP LT+ +G+RA+ + ++ D +P+ ++ Sbjct: 178 DADGEPVGGLSMLVPARD--LTVEDTWHTVGMRATGSHTVVLRDTFVPEHRVISGELQRS 235 Query: 258 -----GMGFKIAMQTLDMGRIGI--ASQALGIAQASLDCAVKYAENRHAFGAPL---TKL 307 +G +T + + + AS LG QA+ V+ A R + T Sbjct: 236 RESATDLGLPPLFRTAAIAAMAVVCASVVLGAGQAARALVVEKAPTRGIAPSKYTRQTDS 295 Query: 308 QNIQFKLADMALALESARLLTWRAAMLKDNKKPFTKESAMAKLA--------ASEAATAI 359 + L AL++++A + RAA D+ ++L A T Sbjct: 296 RTFVSSLGRTALSIDAAEMHVARAATALDDAAYDAVALPDSELLRIRGDVGQAVSLVTTA 355 Query: 360 SHQAIQILGGMGYVTEMPAERYYRDA 385 + + G + P +RY+RDA Sbjct: 356 LDELLWAHGAASFAESNPLQRYWRDA 381 >2OR0-A nrPDB Length = 414 Score = 93.5 bits (231), Expect = 2e-19, Method: Composition-based stats. Identities = 58/369 (15%), Positives = 130/369 (35%), Gaps = 47/369 (12%) Query: 47 DFAEKELVPIAAQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEIS 106 + +E+ A Q + + + + + G + + P G + ++ + ++ Sbjct: 30 EVVAEEIRGQAVQSEADCRLTDAAAGLLRDSGAIRLLQPRLYGGYEVHPREFAETVMGVA 89 Query: 107 RGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWITPFTNGDKIGCFALSEPGNGSDAGAA 166 ++G + + ++ + Q++ W G+ + S A Sbjct: 90 ALDGASGWVTGI-VGVHPWELAFADPQVQEEIW------GEDNDTWMAS-------PYAP 135 Query: 167 STTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISA-----FLVPMPTPG 221 A +VL G ++ + + + A GI+ ++P Sbjct: 136 MGVATPVDGGYVLKGRWSFSSGTDHCQWAFLGAMVGD--GEGGIATPSSLHVILPRTDYQ 193 Query: 222 LTLGKKEDKLGIRASSTANLIFEDCRIPKENLL--------------GEPGMGFKIAMQT 267 + + D +G+R + + +LI + +P L G P F + Sbjct: 194 I-VEDTWDVIGLRGTGSKDLIVDGAFVPGYRTLNAAKVMDGRAQKEAGRPEPLFNMPYSC 252 Query: 268 LDMGRIGIASQALGIAQASLDCAVKYAENRHA-FGAPLTKLQNIQFKLADMALALESARL 326 + +GI + +GI + +L C + ++R A G + + + + + A + ++R+ Sbjct: 253 MFP--LGITAAVIGITEGALACHIAVQKDRVAITGQKIKEDPYVLSAIGESAAEINASRV 310 Query: 327 LTWRAAMLK----DNKKPFT-KESAMAKLAASEAATAISHQAIQIL---GGMGYVTEMPA 378 A D K T +E A+ + AA A +I GG + P Sbjct: 311 SLIETADRFYDKVDAGKEITFEERAIGRRTQIAAAWRAVRAADEIFARAGGGALHYKTPM 370 Query: 379 ERYYRDARI 387 +R++RDA Sbjct: 371 QRFWRDAHA 379 >3HWC-A nrPDB Length = 515 Score = 45.7 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 39/241 (16%), Positives = 77/241 (31%), Gaps = 33/241 (13%) Query: 82 MDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLY--------LGPILKFGSS 133 P++ +G + + L EI+ G S G + +N + + G+ Sbjct: 70 WQDPKDAAGLRVKRKYHETILREIAAG--SYGRLPDAHNYTFTTYADDPEVWEKQSIGAE 127 Query: 134 -----QQKQQWITPFTNGDKIGCFALSEPGN--GSDAGAAST----TAREEGDSWVLNGT 182 Q ++ D +P SDA A + + D ++NG Sbjct: 128 GRNLTQNIHNFLKLLREKDLNCPLNFVDPQTDRSSDAAQARSPNLRIVEKTDDGIIVNGV 187 Query: 183 KAWITNSWEASATVVFASTDRSRQNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTA--- 239 KA T + + + +P TPG+T+ +E + + Sbjct: 188 KAVGTGIAFGDYMHIGCLYRPGIPGEQVIFAAIPTNTPGVTVFCRESTVKNDPAEHPLAS 247 Query: 240 -------NLIFEDCRIPKENL--LGEPGMGFKIAMQTLDMGRIGIASQALGIAQASLDCA 290 +F++ IP E + +G P + D I + + A+ + A Sbjct: 248 QGDELDSTTVFDNVFIPWEQVFHIGNPEHAKLYPQRIFDWVHYHILIRQVLRAELIVGLA 307 Query: 291 V 291 + Sbjct: 308 I 308 >2YYI-A nrPDB Length = 481 Score = 39.9 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 47/240 (19%), Positives = 82/240 (34%), Gaps = 30/240 (12%) Query: 157 PGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGIS-AFLV 215 P D ++ V+ G + T A ++F ST ++ + AF + Sbjct: 155 PSGQPDPYIPVGVVKQTEKGIVVRGARMTATF-PLADEVLIFPSTLLQAGSEKYALAFAL 213 Query: 216 PMPTPGLTLGKKEDKLGIRASSTAN------------LIFEDCRIPKENLLGEPGM---- 259 P TPGL +E +G S + +IF+D +P E + + Sbjct: 214 PTSTPGLHFVCREALVG-GDSPFDHPLSSRVEEMDCLVIFDDVLVPWERVFILGNVELCN 272 Query: 260 GFKIAMQTLDMGRIGIASQALGIAQASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMAL 319 A L+ + + +A L A AE GA + +Q K+A++ + Sbjct: 273 NAYAATGALNHMAHQVVALKTAKTEAFLGVAALMAEG---IGADVYGH--VQEKIAEIIV 327 Query: 320 ALESARLLTWRAAMLKDNKK-----PFTKESAMAKLAASEAATAISHQAIQILGGMGYVT 374 LE+ R RA P A+ I + ++ +G G +T Sbjct: 328 YLEAMRAFWTRAEEEAKENAYGLLVPDRGALDGARNLYPRLYPRI-REILEQIGASGLIT 386 >4G5E-A nrPDB Length = 517 Score = 39.5 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 22/128 (17%), Positives = 38/128 (29%), Gaps = 13/128 (10%) Query: 155 SEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFASTDRSRQNKGISAFL 214 S P + + V++G KA T A + I Sbjct: 162 SNPDAQQRSPGLRV-IEKNDKGIVVSGVKAIGTGVAFADWIHIGVFFRPGIPGDQIIFAA 220 Query: 215 VPMPTPGLTLGKKEDKLGIRASST----------ANLIFEDCRIPKENL--LGEPGMGFK 262 P+ TPG+T+ +E + +F++ IP ++ LG P Sbjct: 221 TPVNTPGVTIVCRESVVKEDPIEHPLASQGDELDGMTVFDNVFIPWSHVFHLGNPEHAKL 280 Query: 263 IAMQTLDM 270 + D Sbjct: 281 YPQRVFDW 288 >1U8V-A nrPDB Length = 490 Score = 37.6 bits (86), Expect = 0.011, Method: Composition-based stats. Identities = 41/272 (15%), Positives = 86/272 (31%), Gaps = 54/272 (19%) Query: 138 QWITPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSW-----------VLNGTKAWI 186 +++ D I A+++P + +A+++ D + V+ G KA Sbjct: 133 EYLKYIQENDLIVDGAMTDPKG---DRGLAPSAQKDPDLFLRIVEKREDGIVVRGAKAHQ 189 Query: 187 TNSWEASATVVF---ASTDRSRQNKGISAFLVPMPTPGLTLGK-----KEDKL------- 231 T S + ++ A T+ + +F P GL + K+ Sbjct: 190 TGSINSHEHIIMPTIAMTEADKDYA--VSFACPSDADGLFMIYGRQSCDTRKMEEGADID 247 Query: 232 -GIRASSTAN--LIFEDCRIPKENL-LGEPGMGFKIAMQTL-DMGRIGIASQALGIAQ-- 284 G + ++F++ IP + + L + + ++ R +G+ Sbjct: 248 LGNKQFGGQEALVVFDNVFIPNDRIFLCQEYDFAGMMVERFAGYHRQSYGGCKVGVGDVV 307 Query: 285 -ASLDCAVKYAENRHAFGAPLTKLQNIQFKLADMALALESARLLTWRAAMLKD---NKKP 340 + A Y + A +++ KL +M L A + Sbjct: 308 IGAAALAADYNGAQKA--------SHVKDKLIEM-THLNETLYCCGIACSAEGYPTAAGN 358 Query: 341 FTKESAMA---KLAASEAATAISHQAIQILGG 369 + + +A K + I A I GG Sbjct: 359 YQIDLLLANVCKQNITRFPYEIVRLAEDIAGG 390 >1REO-A nrPDB Length = 486 Score = 35.3 bits (80), Expect = 0.046, Method: Composition-based stats. Identities = 24/100 (24%), Positives = 42/100 (42%), Gaps = 8/100 (8%) Query: 19 ARDWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGEL- 77 D + + LPE H+++R+ R F +L + + D F + K++GE+ Sbjct: 76 RNDKEDWYANLGPMRLPEKHRIVREYIRKFG-LQLNEFSQENDNAWYFIKNIRKRVGEVK 134 Query: 78 ---GLLAMDV-PEELSGAGLDYLAYSI--ALEEISRGCAS 111 G+L V P E + S+ +EE+ R S Sbjct: 135 KDPGVLKYPVKPSEEGKSAGQLYEESLGKVVEELKRTNCS 174 >1F8S-A nrPDB Length = 498 Score = 34.9 bits (79), Expect = 0.058, Method: Composition-based stats. Identities = 25/93 (26%), Positives = 41/93 (44%), Gaps = 8/93 (8%) Query: 26 HTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPTSQVKKMGEL----GLLA 81 + + LPE H+++R+ R F + L + + D F + KK+GE+ GLL Sbjct: 83 YANLGPMRLPEKHRIVREYIRKF-DLRLNEFSQENDNAWYFIKNIRKKVGEVKKDPGLLK 141 Query: 82 MDV-PEELSGAGLDYLAYSI--ALEEISRGCAS 111 V P E + S+ +EE+ R S Sbjct: 142 YPVKPSEAGKSAGQLYEESLGKVVEELKRTNCS 174 >3J8G-X nrPDB Length = 490 Score = 32.6 bits (73), Expect = 0.37, Method: Composition-based stats. Identities = 19/113 (16%), Positives = 41/113 (36%), Gaps = 11/113 (9%) Query: 248 IPKENLLGEPGMGFKIAMQTLDMGRIGIASQALGIAQ-----ASLDCAVKYAENRHAFGA 302 +P L+G P +G L R + + G+ + + ++ G Sbjct: 2 VPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGRAEIEGREFICIDT--GG 59 Query: 303 PLTKLQNIQFKLAD-MALALESARLLTWRAAMLKDNKKPFTKESAMAKLAASE 354 ++ ++A+ LA+E A ++ + M+ + A+AK S Sbjct: 60 IDGTEDGVETRMAEQSLLAIEEADVVLF---MVDARAGLMPADEAIAKHLRSR 109 >4AYX-A nrPDB Length = 595 Score = 31.8 bits (71), Expect = 0.60, Method: Composition-based stats. Identities = 14/72 (19%), Positives = 26/72 (36%), Gaps = 4/72 (5%) Query: 14 GRALRARDWRRLHTVYQSVELPETHQMLRQTCRDFAEK--ELVPIAAQLDKEHLFPTSQV 71 GR LR ++ Q+ +L E +T R F ++ E+ A+++D Sbjct: 183 GRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARK-- 240 Query: 72 KKMGELGLLAMD 83 + G Sbjct: 241 EAFARAGFFGAT 252 >4QNW-A nrPDB Length = 392 Score = 30.3 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 14/67 (20%), Positives = 26/67 (38%), Gaps = 9/67 (13%) Query: 314 LADMALALESARLLTWRA-----AMLKDNKKPFTKESAMAKLAASEAATAISHQAIQILG 368 LADM + S+ + A+ +D + + A A + A ++I G Sbjct: 119 LADMKDLISSSAVPVEEKGPLPRALTEDEIQQCIADFAQA----ARNAINAGFDGVEIHG 174 Query: 369 GMGYVTE 375 GY+ + Sbjct: 175 ANGYLID 181 >2XSG-A nrPDB Length = 774 Score = 29.5 bits (65), Expect = 3.0, Method: Composition-based stats. Identities = 48/332 (14%), Positives = 93/332 (28%), Gaps = 52/332 (15%) Query: 2 AAALLARA--GGSLGRALRA-RDWRRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIA- 57 +A L R G+ G +++ D L + + L E + LR+ EK P A Sbjct: 442 SADELRRGYVAGNPGASVQRGYDQYGLSVIADELGLTEEAETLREQASWPIEKLTKPGAW 501 Query: 58 -----------AQLDKEHLFPTSQVKKMGELGLLAMDVPEELSGAGLDYLAYSIALEEIS 106 + + ++ K GL + + D A A+ Sbjct: 502 TAADGTQVGLLTPRAADGSWQSADHAKFEAAGLYQGTLWQYHWYDAYDMDALVEAMGGHE 561 Query: 107 RGCASTGVIMSVNN---------------SLYLGPILKF-GSSQQKQQWITPFTNGDKIG 150 + + L + + G Q+W + Sbjct: 562 AARLGMRHMFGEHAPDDGKAMLHSNANEIDLQAPYLFNYTGEPSLTQKWARAIYTKETWN 621 Query: 151 CFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEA---SATVVFASTDRSRQN 207 + + + +G T + + L+ T +A S V A+ Sbjct: 622 RYIATGSSSAVPSGGGEFTPPLKTKVYRLDPRGMLPTMDNDAGTMSTMFVAAAVGLFPVT 681 Query: 208 KGISAFLVPMPTPGLTLGKKEDKLGIRASSTANLI----------------FEDCRIPKE 251 G S F V +P G + TA+ + F + + Sbjct: 682 AGSSQFQV--GSPFFDSTTITYDDGSAFTVTADGVSEDAFYVQSATLDGATFGNTWVDYA 739 Query: 252 NLLGEPGMGFKIAMQTLDMGRIGIASQALGIA 283 ++G + F++ Q D G + ++ A Sbjct: 740 TVVGGADLAFRMGEQPSDWGTDTAPAFSMSTA 771 >2Q3R-A nrPDB Length = 372 Score = 29.1 bits (64), Expect = 3.4, Method: Composition-based stats. Identities = 6/26 (23%), Positives = 11/26 (42%) Query: 350 LAASEAATAISHQAIQILGGMGYVTE 375 A+ A ++I G GY+ + Sbjct: 166 RLAARNAMEAGFDGVEIHGANGYLID 191 >3DR5-A nrPDB Length = 221 Score = 29.1 bits (64), Expect = 3.6, Method: Composition-based stats. Identities = 27/142 (19%), Positives = 41/142 (28%), Gaps = 20/142 (14%) Query: 141 TPFTNGDKIGCFALSEPGNGSDAGAASTTAREEGDSWVLNGTKAWITNSWEASATVVFAS 200 G + A + GNGS A T A ++LNG A T + Sbjct: 37 PDEMTGQLLTTLAATTNGNGSTGAIAITPAAGLVGLYILNG---------LADNTTLTCI 87 Query: 201 TDRSRQNKGISAFLVPMP-TPG---LTLGKKEDKLGIRASSTANLIFEDCR-------IP 249 S + A +P L + D + A+ + L+F + Sbjct: 88 DPESEHQRQAKALFREAGYSPSRVRFLLSRPLDVMSRLANDSYQLVFGQVSPMDLKALVD 147 Query: 250 KENLLGEPGMGFKIAMQTLDMG 271 L G +A LD Sbjct: 148 AAWPLLRRGGALVLADALLDGT 169 >3TD7-A nrPDB Length = 295 Score = 29.1 bits (64), Expect = 3.7, Method: Composition-based stats. Identities = 12/39 (30%), Positives = 19/39 (48%), Gaps = 2/39 (5%) Query: 163 AGAASTTAREEGDSWVLNG--TKAWITNSWEASATVVFA 199 A + +TA+ + ++ NG TK W T W + V F Sbjct: 19 APNSESTAKMDHSNYQHNGLITKIWGTAGWTFNHAVTFG 57 >2X5D-A nrPDB Length = 412 Score = 29.1 bits (64), Expect = 4.0, Method: Composition-based stats. Identities = 19/119 (15%), Positives = 35/119 (29%), Gaps = 29/119 (24%) Query: 11 GSLGRALRARDW--RRLHTVYQSVELPETHQMLRQTCRDFAEKELVPIAAQLDKEHLFPT 68 +L R D+ V L Q +R R + ++ Sbjct: 265 SALARIKSYHDYGTFTPLQVAAIAALEGDQQCVRDIARQYQQRR---------------D 309 Query: 69 SQVKKMGELGLLA----------MDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMS 117 VK + E G + +PE + G L ++ L + ++ S G+ Sbjct: 310 VLVKGLREAGWMVENPKASMYVWAKIPEPYAHLG--SLEFAKKLLQDAKVSVSPGIGFG 366 >3L73-B nrPDB Length = 441 Score = 28.7 bits (63), Expect = 5.1, Method: Composition-based stats. Identities = 11/59 (18%), Positives = 23/59 (38%), Gaps = 3/59 (5%) Query: 75 GELGLLAMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSS 133 + ++ E+ + ++ E + G A + + L GP++K GSS Sbjct: 237 AKATYWGGEIREQNGH---SLVHAAVVTEGAAVGSAEANAFSVLQHVLGAGPLIKRGSS 292 >1AKL-A nrPDB Length = 470 Score = 27.6 bits (60), Expect = 9.9, Method: Composition-based stats. Identities = 22/121 (18%), Positives = 40/121 (33%), Gaps = 16/121 (13%) Query: 81 AMDVPEELSGAGLDYLAYSIALEEISRGCASTGVIMSVNNSLYLGPILKFGSSQQKQQWI 140 + + GAG D Y E + + +S + + L + F + Q++ Sbjct: 361 GLGADQLWGGAGADTFVYGDIAESSAAAPDTLRDFVSGQDKIDLSGLDAFVNGGLVLQYV 420 Query: 141 TPFT--NGDKIGCFALSEPGNGSDAGAASTTAREEGD---SWVLNGTKAWITNSWEASAT 195 F G I + S AG+ + GD + +N I + +A Sbjct: 421 DAFAGKAGQAILSY-----DAASKAGSLA--IDFSGDAHADFAIN----LIGQATQADIV 469 Query: 196 V 196 V Sbjct: 470 V 470 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.146 0.393 Lambda K H 0.267 0.0445 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,185,953 Number of Sequences: 36641 Number of extensions: 666327 Number of successful extensions: 2521 Number of sequences better than 10.0: 109 Number of HSP's better than 10.0 without gapping: 157 Number of HSP's successfully gapped in prelim test: 36 Number of HSP's that attempted gapping in prelim test: 1984 Number of HSP's gapped (non-prelim): 203 length of query: 412 length of database: 10,336,785 effective HSP length: 99 effective length of query: 313 effective length of database: 6,709,326 effective search space: 2100019038 effective search space used: 2100019038 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 61 (28.0 bits)