BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P15538 (503 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6M7X-A nrPDB 977 0.0 4ZGX-A nrPDB 880 0.0 3MZS-A nrPDB 345 4e-95 3N9Z-A nrPDB 340 9e-94 3K9V-A nrPDB 214 7e-56 5VEU-A nrPDB 101 7e-22 4R1Z-A nrPDB 96 3e-20 6B82-A nrPDB 95 8e-20 6DA2-A nrPDB 94 1e-19 5YLW-A nrPDB 94 1e-19 3DL9-A nrPDB 84 1e-16 4R20-A nrPDB 83 3e-16 2VE3-A nrPDB 80 3e-15 6C94-A nrPDB 79 4e-15 5VBU-A nrPDB 76 3e-14 3E6I-A nrPDB 74 1e-13 5UYS-A nrPDB 73 3e-13 2PG7-A nrPDB 72 5e-13 5W0C-A nrPDB 72 7e-13 3TBG-A nrPDB 69 4e-12 3S79-A nrPDB 68 8e-12 4GQS-A nrPDB 67 1e-11 1N6B-A nrPDB 67 2e-11 3MDV-A nrPDB 67 2e-11 3QZ1-A nrPDB 67 2e-11 6DWN-A nrPDB 66 3e-11 2NNH-A nrPDB 65 6e-11 3MGX-A nrPDB 65 6e-11 5FOI-A nrPDB 65 7e-11 3SN5-A nrPDB 64 1e-10 6IQ5-A nrPDB 64 2e-10 4KPA-A nrPDB 63 2e-10 3IBD-A nrPDB 62 6e-10 6AYB-A nrPDB 62 6e-10 4H1N-A nrPDB 62 8e-10 6GMF-A nrPDB 61 1e-09 2HI4-A nrPDB 60 2e-09 2RFC-A nrPDB 60 2e-09 6B11-A nrPDB 59 4e-09 5VWS-A nrPDB 59 4e-09 5E0E-A nrPDB 58 7e-09 2W0A-A nrPDB 58 7e-09 5E58-A nrPDB 58 1e-08 4WMZ-A nrPDB 58 1e-08 4UBS-A nrPDB 56 3e-08 3TYW-A nrPDB 56 3e-08 3JUS-A nrPDB 56 4e-08 1WIY-A nrPDB 55 5e-08 3RWL-A nrPDB 55 5e-08 3ABA-A nrPDB 55 6e-08 2ZBZ-A nrPDB 55 6e-08 5IT1-A nrPDB 55 9e-08 3TKT-A nrPDB 55 1e-07 5JLC-A nrPDB 54 1e-07 6HQG-A nrPDB 54 1e-07 6F0B-A nrPDB 54 1e-07 5FYF-A nrPDB 53 2e-07 4RM4-A nrPDB 53 3e-07 3EL3-A nrPDB 53 3e-07 6HQW-A nrPDB 52 4e-07 3R9C-A nrPDB 52 5e-07 3A1L-A nrPDB 52 7e-07 5DE9-A nrPDB 51 1e-06 2XKR-A nrPDB 51 1e-06 2FR7-A nrPDB 51 2e-06 2IAG-A nrPDB 50 2e-06 1UE8-A nrPDB 50 2e-06 4WPZ-A nrPDB 50 2e-06 4DO1-A nrPDB 50 2e-06 3ABB-A nrPDB 50 2e-06 3NC3-A nrPDB 50 3e-06 2X2N-A nrPDB 50 3e-06 5LIE-A nrPDB 50 3e-06 2Z36-A nrPDB 49 5e-06 5OFQ-A nrPDB 49 6e-06 4PWV-A nrPDB 49 6e-06 5YHJ-A nrPDB 48 1e-05 4YZR-A nrPDB 48 1e-05 6GK6-A nrPDB 47 2e-05 2WX2-A nrPDB 47 2e-05 1CPT-A nrPDB 47 3e-05 6GII-A nrPDB 47 3e-05 2WIO-A nrPDB 47 3e-05 3OFT-A nrPDB 46 3e-05 5YSW-A nrPDB 46 3e-05 4TRI-A nrPDB 46 3e-05 5D3U-A nrPDB 46 3e-05 3EJB-B nrPDB 46 4e-05 6HQD-A nrPDB 45 6e-05 2VZM-A nrPDB 45 6e-05 5XJN-A nrPDB 45 9e-05 6FYJ-A nrPDB 45 9e-05 5GWE-A nrPDB 45 9e-05 5Y1I-A nrPDB 44 1e-04 4OQS-A nrPDB 44 1e-04 4OQR-A nrPDB 44 1e-04 5FSA-A nrPDB 44 2e-04 5H1Z-A nrPDB 44 2e-04 2ZQJ-A nrPDB 44 2e-04 2Y5N-A nrPDB 44 2e-04 4GGV-A nrPDB 43 3e-04 5CJE-A nrPDB 43 3e-04 3A50-A nrPDB 43 3e-04 2WIY-A nrPDB 43 3e-04 1Z8P-A nrPDB 43 4e-04 6CVC-A nrPDB 43 4e-04 3L4D-A nrPDB 42 4e-04 5HDI-A nrPDB 42 5e-04 4Z5P-A nrPDB 42 6e-04 1LG9-A nrPDB 42 6e-04 6CR2-A nrPDB 42 7e-04 5HH3-A nrPDB 41 0.001 5L94-A nrPDB 41 0.001 1UED-A nrPDB 41 0.001 1F4U-A nrPDB 40 0.002 3P3Z-A nrPDB 40 0.002 5M0P-A nrPDB 40 0.002 5EX6-C nrPDB 40 0.002 2NZA-A nrPDB 40 0.002 5L1U-A nrPDB 40 0.002 6G5O-A nrPDB 40 0.002 6G71-A nrPDB 40 0.003 3NV6-A nrPDB 40 0.003 4XE3-A nrPDB 39 0.005 4MM0-A nrPDB 39 0.006 2WM5-A nrPDB 39 0.006 5NWS-A nrPDB 39 0.006 3WVS-A nrPDB 38 0.008 1GWI-A nrPDB 38 0.009 4YT3-A nrPDB 37 0.015 5LIV-A nrPDB 37 0.023 5XW2-A nrPDB 37 0.025 3AWQ-A nrPDB 37 0.027 6F88-A nrPDB 37 0.028 1Q5D-A nrPDB 36 0.030 5HIW-A nrPDB 36 0.037 5ZR1-C nrPDB 35 0.082 6DCD-A nrPDB 35 0.095 1EHE-A nrPDB 35 0.11 5EX8-A nrPDB 35 0.11 6A7J-A nrPDB 34 0.17 5OMS-A nrPDB 33 0.23 6FSH-A nrPDB 33 0.29 6M7L-A nrPDB 33 0.37 4TX3-A nrPDB 33 0.42 4JBT-A nrPDB 32 0.46 2UUQ-A nrPDB 32 0.47 2X9P-A nrPDB 32 0.49 3DBM-A nrPDB 32 0.66 5XNT-A nrPDB 32 0.92 2YJN-B nrPDB 31 0.98 1XDN-A nrPDB 31 1.1 5OQL-R nrPDB 31 1.1 3BUJ-A nrPDB 31 1.3 4Z5Q-A nrPDB 31 1.3 2RCM-A nrPDB 31 1.4 6A7I-A nrPDB 31 1.4 1V10-A nrPDB 30 1.8 5KYO-A nrPDB 30 2.0 5YS9-A nrPDB 30 2.6 3OO3-A nrPDB 30 3.0 2QBO-A nrPDB 29 4.1 4FB2-A nrPDB 28 8.2 >6M7X-A nrPDB Length = 484 Score = 977 bits (2525), Expect = 0.0, Method: Compositional matrix adjust. Identities = 473/480 (98%), Positives = 476/480 (99%) Query: 24 LGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDL 83 + + + VPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDL Sbjct: 1 MAKKTSSVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDL 60 Query: 84 GGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR 143 GGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR Sbjct: 61 GGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR 120 Query: 144 LNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 203 LNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA Sbjct: 121 LNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 180 Query: 204 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCI 263 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCI Sbjct: 181 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCI 240 Query: 264 FQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPL 323 FQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPL Sbjct: 241 FQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPL 300 Query: 324 LMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 383 LMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE Sbjct: 301 LMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 360 Query: 384 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF 443 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF Sbjct: 361 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF 420 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN 503 GFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN Sbjct: 421 GFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN 480 >4ZGX-A nrPDB Length = 489 Score = 880 bits (2273), Expect = 0.0, Method: Compositional matrix adjust. Identities = 446/480 (92%), Positives = 457/480 (95%) Query: 24 LGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDL 83 + T+AAR PRTVLPFEAMP+ PGNRWLRLLQIWREQGYE LHLE+HQTFQELGPIFRY+L Sbjct: 1 MATKAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNL 60 Query: 84 GGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR 143 GG MVCVMLPEDVEKLQQVDSLHP RM LEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR Sbjct: 61 GGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR 120 Query: 144 LNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 203 LNP+VLSP AVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA Sbjct: 121 LNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 180 Query: 204 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCI 263 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRW SPKVWKEHFEAWDCI Sbjct: 181 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCI 240 Query: 264 FQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPL 323 FQYGDNCIQKIYQELAF+RPQ YT IVAELLL AELS +AIKANSMELTAGSVDTT FPL Sbjct: 241 FQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPL 300 Query: 324 LMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 383 LMTLFELARNP+VQQ LRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE Sbjct: 301 LMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 360 Query: 384 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF 443 RV SSDLVLQNYHIPAGTLV+VFLYSLGRN ALFPRPERYNPQRWLDIRGSGRNF+HVPF Sbjct: 361 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF 420 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN 503 GFGMRQCLGRRLAEAEMLLLLHHVLKH VETLTQEDIKMVYSFILRP PLLTFRAIN Sbjct: 421 GFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN 480 >3MZS-A nrPDB Length = 486 Score = 345 bits (884), Expect = 4e-95, Method: Compositional matrix adjust. Identities = 175/477 (36%), Positives = 279/477 (58%), Gaps = 4/477 (0%) Query: 28 AARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAG 87 + + PR P+ +P N WL L WRE+G + +H + FQ+ GPI+R LG Sbjct: 3 STKTPR---PYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLE 59 Query: 88 MVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPE 147 V ++ PEDV L + + +P R + PW+AY ++ GV W+ +R+ LN E Sbjct: 60 SVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTE 119 Query: 148 VLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGE 207 V++P A++ F+P+++ V++DF L K++ Q G D++ +FH+ E+ +FGE Sbjct: 120 VMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGE 179 Query: 208 RLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYG 267 RLG++ + + + F+ A+ MF ++V L+ +P L R K W++H AWD IF Sbjct: 180 RLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKA 239 Query: 268 DNCIQKIYQELA-FSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMT 326 + + YQ+L + + Y I+ LL + ++ + +KAN E+ AG V+TT L Sbjct: 240 EKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWH 299 Query: 327 LFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVA 386 L+E+AR+ NVQ+ LR+E L A K +PLL+A++KETLRL+P+ + L+R Sbjct: 300 LYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYP 359 Query: 387 SSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFG 446 SDLVLQ+Y IPA TLV+V +Y++GR+PA F P++++P RWL +F ++ FG+G Sbjct: 360 ESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWG 419 Query: 447 MRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN 503 +RQC+GRR+AE EM L L H+L++ +VE D+ +++ IL P L FR N Sbjct: 420 VRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFN 476 >3N9Z-A nrPDB Length = 487 Score = 340 bits (872), Expect = 9e-94, Method: Compositional matrix adjust. Identities = 186/478 (38%), Positives = 269/478 (56%), Gaps = 5/478 (1%) Query: 28 AARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAG 87 + R PR PF +P N WL L WRE G +HL Q FQ+ GPI+R LG Sbjct: 1 STRSPR---PFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVE 57 Query: 88 MVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPE 147 V V+ PEDV L + + +P R + PWVAY Q+ GV L W+ +R+ LN E Sbjct: 58 SVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQE 117 Query: 148 VLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGE 207 V++P A + FLP++DAV+RDF L +++ + G+ + D+ +F + E+ +FGE Sbjct: 118 VMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGE 177 Query: 208 RLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYG 267 R G++ + + F+ A+ MF ++V ++ +P L R K WK+H AWD IF Sbjct: 178 RQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKA 237 Query: 268 DNCIQKIYQEL--AFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLM 325 D Q Y EL S Y I+ LL ++++S + IKAN E+ AG VDTT L Sbjct: 238 DIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQW 297 Query: 326 TLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERV 385 L+E+ARN VQ LR E LAA +PLL+A++KETLRL+P+ + L+R Sbjct: 298 HLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRY 357 Query: 386 ASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGF 445 +DLVL++Y IPA TLV+V +Y+LGR P F PE ++P RWL + F ++ FG+ Sbjct: 358 LVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGW 417 Query: 446 GMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN 503 G+RQCLGRR+AE EM + L ++L++ +VE D+ ++ IL P TF N Sbjct: 418 GVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFN 475 >3K9V-A nrPDB Length = 482 Score = 214 bits (545), Expect = 7e-56, Method: Compositional matrix adjust. Identities = 132/449 (29%), Positives = 219/449 (48%), Gaps = 6/449 (1%) Query: 52 LLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRM 111 LL+I+ + G + H + + ++ G IFR LG V + P +E L + +S HP R+ Sbjct: 38 LLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEALYRTESAHPQRL 97 Query: 112 SLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQA 171 ++PW AYR HR G+ +L G EW+ R +++ P + + ++ V DF + Sbjct: 98 EIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLER 157 Query: 172 LKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMF 231 + + L + RG + D+ + ++ E+ L L+ +R GL+ +L F+ A++ M Sbjct: 158 MDE--LCDERGRIP-DLYSELNKWSFESICLVLYEKRFGLLQKETEEEALTFITAIKTMM 214 Query: 232 KSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVA 291 + ++M P L + + KVW+ H AWD IF+ CI Q + Q + Sbjct: 215 STFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYS---QQPGADFLC 271 Query: 292 ELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASI 351 ++ LS + A EL +V+TT L+ L+ L+RNP Q+ L QE + Sbjct: 272 DIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDN 331 Query: 352 SEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLG 411 + +P L+A LKE++RL P F R VL Y +P GT++ + LG Sbjct: 332 QTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLG 391 Query: 412 RNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471 + F ++ P+RWL F H+PFG G R C+GRRLAE ++ L L +++ Sbjct: 392 SSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKY 451 Query: 472 QVETLTQEDIKMVYSFILRPSMFPLLTFR 500 + E ++M++ IL PS + FR Sbjct: 452 DIVATDNEPVEMLHLGILVPSRELPIAFR 480 >5VEU-A nrPDB Length = 480 Score = 101 bits (252), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 63/195 (32%), Positives = 100/195 (51%), Gaps = 2/195 (1%) Query: 299 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKA 358 LS + A S+ +TT L TL+ELA +P+VQQ L++E A + + A Sbjct: 269 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 328 Query: 359 TTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFP 418 ++ L + ETLRL+PV + LER D+ + IP G++V + Y+L +P + Sbjct: 329 VVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWT 388 Query: 419 RPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETL-- 476 PE + P+R+ + S + + PFG G R C+G R A M L L VL++ + Sbjct: 389 EPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKE 448 Query: 477 TQEDIKMVYSFILRP 491 TQ +K+ +L+P Sbjct: 449 TQIPLKLDTQGLLQP 463 >4R1Z-A nrPDB Length = 439 Score = 96.3 bits (238), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 72/252 (28%), Positives = 120/252 (47%), Gaps = 23/252 (9%) Query: 268 DNCIQKIYQELAFSRPQQYTSIVAELLLNAE--------------LSPDAIKANSMELTA 313 D +QK Y+E + + + LL A+ L+ D + ++ Sbjct: 173 DKLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDIFG 232 Query: 314 GSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKAT-TELPLLRAALKET 372 V+TT L ++ L NP VQ+ + QE L + HPQ + LP L A ++E Sbjct: 233 AGVETTTTVLKWSIAYLVHNPQVQRKI-QEELDSKIGKERHPQLSDRGNLPYLEATIREV 291 Query: 373 LRLYPVG-LFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDI 431 LR+ PV L + VA D + Y + GT V + L+SL + + PE ++P R+L+ Sbjct: 292 LRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLNE 351 Query: 432 RGSGR---NFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQE---DIKMVY 485 G G + ++PFG G+R CLG LA+ E+ L L +L+ +E T + D++ + Sbjct: 352 EGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKF 411 Query: 486 SFILRPSMFPLL 497 +L+P F ++ Sbjct: 412 GVVLQPKKFKVV 423 >6B82-A nrPDB Length = 509 Score = 94.7 bits (234), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 71/252 (28%), Positives = 119/252 (47%), Gaps = 23/252 (9%) Query: 268 DNCIQKIYQELAFSRPQQYTSIVAELLLNAE--------------LSPDAIKANSMELTA 313 D +QK Y+E + + + LL A+ L+ D + E+ Sbjct: 237 DKLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFG 296 Query: 314 GSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKAT-TELPLLRAALKET 372 V+TT L ++ L NP VQ+ + QE L + HPQ + LP L A + E Sbjct: 297 AGVETTTTTLKWSIAYLVHNPQVQRKI-QEELDSKIGKERHPQLSDRGNLPYLEATICEV 355 Query: 373 LRLYPVG-LFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDI 431 +R+ PV L + VA D + Y + GT V + ++SL + + PE ++P R+L+ Sbjct: 356 MRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNE 415 Query: 432 RGSGR---NFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQE---DIKMVY 485 G G + ++PFG G+R CLG LA+ E+ L L +L+ +E T + D++ + Sbjct: 416 EGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKF 475 Query: 486 SFILRPSMFPLL 497 +L+P F ++ Sbjct: 476 GVVLQPKKFKVV 487 >6DA2-A nrPDB Length = 487 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 61/196 (31%), Positives = 99/196 (50%), Gaps = 3/196 (1%) Query: 299 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKA 358 LS + A S+ +TT L ++ELA +P+VQQ L++E A + + Sbjct: 270 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 329 Query: 359 TTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFP 418 ++ L + ETLRL+P+ + LERV D+ + IP G +V + Y+L R+P + Sbjct: 330 VLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWT 389 Query: 419 RPERYNPQRWLDIRGSGRNFY-HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETL- 476 PE++ P+R+ + Y + PFG G R C+G R A M L L VL++ + Sbjct: 390 EPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCK 449 Query: 477 -TQEDIKMVYSFILRP 491 TQ +K+ +L+P Sbjct: 450 ETQIPLKLSLGGLLQP 465 >5YLW-A nrPDB Length = 495 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 58/174 (33%), Positives = 91/174 (52%), Gaps = 15/174 (8%) Query: 298 ELSPDAIKANS------------MELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESL 345 E+ D I+AN ++L G DT + + EL NP+ L+ E Sbjct: 270 EIVVDIIQANEFKLKTHHFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELK 329 Query: 346 AAAASISEHPQKATTELPLLRAALKETLRLYPVG-LFLERVASSDLVLQNYHIPAGTLVR 404 + A + A +LP L+A +KE +R++P G L L R A SD + Y IP GT + Sbjct: 330 SVAGDEKIVDESAMPKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQIL 389 Query: 405 VFLYSLGRNPALFPRPERYNPQRWLD--IRGSGRNFYHVPFGFGMRQCLGRRLA 456 + Y++GR+P+++ PE ++P+R+LD I G+++ +PFG G R C G LA Sbjct: 390 INAYAIGRDPSIWTDPETFDPERFLDNKIDFKGQDYELLPFGSGRRVCPGMPLA 443 >3DL9-A nrPDB Length = 479 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 111/451 (24%), Positives = 181/451 (40%), Gaps = 46/451 (10%) Query: 65 HLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDV--EKLQQVDSLHPHRMSLEPWVAYRQH 122 H+ + + Q G IF DLGG V V+ DV E L + R L ++ + Sbjct: 37 HVYMRKQSQVYGEIFSLDLGGISTV-VLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKM 95 Query: 123 RGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALK--KKVLQNA 180 G LLN R+ R ++ L+ N+ + F + + K ++ Sbjct: 96 GG------LLNS---RYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETY 146 Query: 181 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQL--- 237 +G D + I + +NL +FGER + +F H +E +F V+L Sbjct: 147 KGR-PFDFKQLITNAVSNITNLIIFGERF-------TYEDTDFQHMIE-LFSENVELAAS 197 Query: 238 --MFMPRSLSRWTSPKVWKEH---FEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAE 292 +F+ + W + +H F ++ + I+K PQ + + Sbjct: 198 ASVFLYNAFP-WIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLD 256 Query: 293 LLLNAELSPDAI--KANSM----ELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLA 346 + + P + K N + EL +TT L + +A PN+Q +++E Sbjct: 257 EMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDL 316 Query: 347 AAASISEHPQKATTELPLLRAALKETLR---LYPVGLFLERVASSDLVLQNYHIPAGTLV 403 + ++P A L E LR + P+G+F S D V++ Y IP GT V Sbjct: 317 IMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIF--HATSEDAVVRGYSIPKGTTV 374 Query: 404 RVFLYSLGRNPALFPRPERYNPQRWLDIRGS-GRNFYHVPFGFGMRQCLGRRLAEAEMLL 462 LYS+ + + PE ++P+R+LD G + VPF G R CLG LA EM L Sbjct: 375 ITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFL 434 Query: 463 LLHHVLK--HLQVETLTQEDIKMVYSFILRP 491 +L+ HL D+K L+P Sbjct: 435 FFTALLQRFHLHFPHELVPDLKPRLGMTLQP 465 >4R20-A nrPDB Length = 486 Score = 83.2 bits (204), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 56/203 (27%), Positives = 102/203 (50%), Gaps = 7/203 (3%) Query: 298 ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQK 357 +++ D + + E V+TT LL T+ L +P +Q+ ++ E L + P Sbjct: 271 DITEDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAE-LDECVGVDRPPCL 329 Query: 358 AT-TELPLLRAALKETLRLYPVG-LFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPA 415 + LPLL A L E +R+ PV + + VA D L + +P GT V V ++++ +P Sbjct: 330 SDRPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPK 389 Query: 416 LFPRPERYNPQRWLDIRGSGRN-FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE 474 + +PE++NP+R+L+ G + +PFG G R C+G LA E+ L + L+ Sbjct: 390 HWDQPEQFNPERFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFS 449 Query: 475 TLTQE---DIKMVYSFILRPSMF 494 ++ D++ + +L+P + Sbjct: 450 CPSEASLPDLQGRFGVVLQPERY 472 >2VE3-A nrPDB Length = 444 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 51/167 (30%), Positives = 85/167 (50%), Gaps = 7/167 (4%) Query: 330 LARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPV--GLFLERVAS 387 L ++ ++++ +RQE S E + ++P L L+E LRL P G F E + Sbjct: 270 LGQHSDIRERVRQEQNKLQLS-QELTAETLKKMPYLDQVLQEVLRLIPPVGGGFRELI-- 326 Query: 388 SDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRN--FYHVPFGF 445 D Q +H P G LV + +P L+P PE+++P+R+ + N F HVPFG Sbjct: 327 QDCQFQGFHFPKGWLVSYQISQTHADPDLYPDPEKFDPERFTPDGSATHNPPFAHVPFGG 386 Query: 446 GMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPS 492 G+R+CLG+ A EM L +++ L +++++V + RP Sbjct: 387 GLRECLGKEFARLEMKLFATRLIQQFDWTLLPGQNLELVVTPSPRPK 433 >6C94-A nrPDB Length = 497 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 78/350 (22%), Positives = 146/350 (41%), Gaps = 28/350 (8%) Query: 128 GVFLLNGPEWRFNRLRLNP----EVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGS 183 G+ +L+GP+W +R L P +VL P A+ D ++ + +K + A Sbjct: 103 GLLVLDGPKWFQHRKLLTPGFHYDVLKPYV---------AIFADSTRIMLEKWEKKACEG 153 Query: 184 LTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRS 243 + D+ + H ++ FG+ + H SS + + L ++ + + Sbjct: 154 KSFDIFSDVGHMALDTLMKCTFGKGDSGLNHRDSSYYVA-VSELTLLMQQRIDSFQYHND 212 Query: 244 LSRWTSPKVWKEHFEAWDCIFQYGDNCI---------QKIYQELAFSRPQQYTSIVAELL 294 W +P + A + D I +K +++ R + I+ ++ Sbjct: 213 FIYWLTPHG-RRFLRACRAAHDHTDRVIRQRKAALQDEKEREKIQNRRHLDFLDILLDVR 271 Query: 295 LNA--ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASIS 352 + +LS ++A DTT + L+ +A P QQ R+E Sbjct: 272 GESGVQLSDTDLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQRCREEVREILGDQD 331 Query: 353 EHPQKATTELPLLRAALKETLRLYP-VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLG 411 + ++ L +KE RLYP V +++ + +PAG+L+ + +Y+L Sbjct: 332 SFQWEDLAKMTYLTMCMKECFRLYPPVPQVYRQLSKPVSFVDGRSLPAGSLISLHIYALH 391 Query: 412 RNPALFPRPERYNPQRWLDIRGSGRNFY-HVPFGFGMRQCLGRRLAEAEM 460 RN ++P PE ++P R+ SGR+ Y +PF G R C+G++ A EM Sbjct: 392 RNSDVWPDPEVFDPLRFSPENSSGRHPYAFIPFSAGPRNCIGQQFAMNEM 441 >5VBU-A nrPDB Length = 476 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 55/166 (33%), Positives = 82/166 (49%), Gaps = 7/166 (4%) Query: 308 SMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE---SLAAAASISEHPQKATTELPL 364 +++L G +TT L + L +P +QQ L++E L AS S P K LPL Sbjct: 267 AVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPL 326 Query: 365 LRAALKETLRLYP-VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERY 423 L A + E LRL P V L L + + Y IP GT++ L + ++ RP + Sbjct: 327 LNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 386 Query: 424 NPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 P R+L+ G+N + FG G R CLG LA E+ ++L +L+ Sbjct: 387 WPDRFLE---PGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQ 429 >3E6I-A nrPDB Length = 476 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 108/430 (25%), Positives = 166/430 (38%), Gaps = 39/430 (9%) Query: 73 QELGPIFRYDLGGAGMVCVMLPEDV-EKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFL 131 Q GP+F +G MV + + V E L R L + A+R G+ Sbjct: 41 QRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDR-----GIIF 95 Query: 132 LNGPEWR-FNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQP 190 NGP W+ R L Q + A +AL+K Q + + P Sbjct: 96 NNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAP 155 Query: 191 SI----------FHYTIEA--SNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLM 238 F Y E + LF E L+ NF L + S +++ Sbjct: 156 CNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVI 215 Query: 239 FMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAE 298 + + S +V KEH ++ D NC + + L ++ S AE L Sbjct: 216 KNVAEVKEYVSERV-KEHHQSLD------PNCPRDLTDCLLVEMEKEKHS--AERLYTM- 265 Query: 299 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKA 358 D I +L +TT L L L + P +++ L +E K Sbjct: 266 ---DGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKD 322 Query: 359 TTELPLLRAALKETLR---LYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPA 415 E+P + A + E R L P L E A+ D + + Y IP GT+V L S+ + Sbjct: 323 RQEMPYMDAVVHEIQRFITLVPSNLPHE--ATRDTIFRGYLIPKGTVVVPTLDSVLYDNQ 380 Query: 416 LFPRPERYNPQRWLDIRGSGR-NFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE 474 FP PE++ P+ +L+ G + + Y PF G R C G LA E+ LLL +L+H ++ Sbjct: 381 EFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 440 Query: 475 TLTQ-EDIKM 483 L +DI + Sbjct: 441 PLVDPKDIDL 450 >5UYS-A nrPDB Length = 494 Score = 73.2 bits (178), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 62/228 (27%), Positives = 110/228 (48%), Gaps = 17/228 (7%) Query: 253 WKEHFEAWDCIFQYGDNCIQ-KIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMEL 311 +KE F + D I D +Q K+ + + P Q + + LS + I ++ Sbjct: 232 YKEKFRS-DSITNMLDTLMQAKMNSDNGNAGPDQDSEL---------LSDNHILTTIGDI 281 Query: 312 TAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKAT-TELPLLRAALK 370 V+TT + TL L NP V++ L +E + S P + L LL A ++ Sbjct: 282 FGAGVETTTSVVKWTLAFLLHNPQVKKKLYEE-IDQNVGFSRTPTISDRNRLLLLEATIR 340 Query: 371 ETLRLYPVG-LFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWL 429 E LRL PV + + A+ D + + + GT V + L++L N + +P+++ P+R+L Sbjct: 341 EVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFL 400 Query: 430 DIRGS---GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE 474 + G+ + ++PFG G R C+G LA E+ L++ +L+ +E Sbjct: 401 NPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 448 >2PG7-A nrPDB Length = 476 Score = 72.4 bits (176), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 45/182 (24%), Positives = 84/182 (46%), Gaps = 2/182 (1%) Query: 296 NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHP 355 N E + +++L G +T L L ++P V+ + +E + Sbjct: 261 NTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPK 320 Query: 356 QKATTELPLLRAALKETLRLYPV-GLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNP 414 + ++P + A + E R V + L R D +++ +P GT V L S+ R+P Sbjct: 321 FEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDP 380 Query: 415 ALFPRPERYNPQRWLDIRGS-GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV 473 + F P+ +NPQ +L+ +G ++ VPF G R C G LA E+ L V+++ ++ Sbjct: 381 SFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL 440 Query: 474 ET 475 ++ Sbjct: 441 KS 442 >5W0C-A nrPDB Length = 477 Score = 71.6 bits (174), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 48/186 (25%), Positives = 89/186 (47%), Gaps = 6/186 (3%) Query: 297 AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQ 356 +E + ++++ +++L +TT L L L ++P V +++E Sbjct: 263 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 322 Query: 357 KATTELPLLRAALKETLR---LYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRN 413 + + +P A + E R L P L + D+ +NY IP GT + + L S+ + Sbjct: 323 QDRSHMPYTDAVVHEVQRYIDLLPTSL--PHAVTCDIKFRNYLIPKGTTILISLTSVLHD 380 Query: 414 PALFPRPERYNPQRWLDIRGS-GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQ 472 FP PE ++P +LD G+ ++ Y +PF G R C+G LA E+ L L +L++ Sbjct: 381 NKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFN 440 Query: 473 VETLTQ 478 +++L Sbjct: 441 LKSLVD 446 >3TBG-A nrPDB Length = 479 Score = 68.9 bits (167), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 53/193 (27%), Positives = 93/193 (48%), Gaps = 10/193 (5%) Query: 311 LTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALK 370 +AG V TT L L + +P+VQ+ ++QE + +P A + Sbjct: 281 FSAGMV-TTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIH 339 Query: 371 ETLR---LYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQR 427 E R + P+G+ + S D+ +Q + IP GT + L S+ ++ A++ +P R++P+ Sbjct: 340 EVQRFGDIVPLGV--THMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEH 397 Query: 428 WLDIRGS-GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQE---DIKM 483 +LD +G + +PF G R CLG LA E+ L +L+H T + Sbjct: 398 FLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHG 457 Query: 484 VYSFILRPSMFPL 496 V++F++ PS + L Sbjct: 458 VFAFLVSPSPYEL 470 >3S79-A nrPDB Length = 503 Score = 68.2 bits (165), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 58/222 (26%), Positives = 102/222 (45%), Gaps = 25/222 (11%) Query: 284 QQYTSIVAELLL---NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQAL 340 ++ EL+L +L+ + + +E+ + DT L LF +A++PNV++A+ Sbjct: 273 EECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAI 332 Query: 341 RQESLAAAASISEHPQKATT--ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIP 398 +E I E K +L ++ + E++R PV + R A D V+ Y + Sbjct: 333 IKE---IQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVK 389 Query: 399 AGTLVRVFLYSLGRNPAL--FPRPERYNPQRWLDIRGSGRNF---YHVPFGFGMRQCLGR 453 GT + + ++GR L FP+P + + + +N Y PFGFG R C G+ Sbjct: 390 KGTNI---ILNIGRMHRLEFFPKPNEFTLENF------AKNVPYRYFQPFGFGPRGCAGK 440 Query: 454 RLAEAEMLLLLHHVLKHLQVETL---TQEDIKMVYSFILRPS 492 +A M +L +L+ V+TL E I+ ++ L P Sbjct: 441 YIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPD 482 >4GQS-A nrPDB Length = 477 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 48/184 (26%), Positives = 85/184 (46%), Gaps = 6/184 (3%) Query: 297 AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQ 356 +E + + + + +L +TT L L L ++P V +++E Sbjct: 263 SEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCM 322 Query: 357 KATTELPLLRAALKETLR---LYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRN 413 + +P A + E R L P L + D+ +NY IP GT + L S+ + Sbjct: 323 QDRGHMPYTDAVVHEVQRYIDLIPTSL--PHAVTCDVKFRNYLIPKGTTILTSLTSVLHD 380 Query: 414 PALFPRPERYNPQRWLDIRGS-GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQ 472 FP PE ++P+ +LD G+ ++ Y +PF G R C+G LA E+ L L +L++ Sbjct: 381 NKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFN 440 Query: 473 VETL 476 +++L Sbjct: 441 LKSL 444 >1N6B-A nrPDB Length = 473 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 48/187 (25%), Positives = 88/187 (47%), Gaps = 6/187 (3%) Query: 296 NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHP 355 N E + +++ +L +TT L +L L ++P V +++E Sbjct: 258 NLEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPEVAARVQEEIERVIGRHRSPC 317 Query: 356 QKATTELPLLRAALKETLR---LYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGR 412 + + +P A + E R L P L + D+ +NY IP GT + L S+ Sbjct: 318 MQDRSRMPYTDAVIHEIQRFIDLLPTNL--PHAVTRDVRFRNYFIPKGTDIITSLTSVLH 375 Query: 413 NPALFPRPERYNPQRWLDIRGS-GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471 + FP P+ ++P +LD G+ ++ Y +PF G R C+G LA E+ L L +L++ Sbjct: 376 DEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRMCVGEGLARMELFLFLTSILQNF 435 Query: 472 QVETLTQ 478 ++++L + Sbjct: 436 KLQSLVE 442 >3MDV-A nrPDB Length = 456 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 90/410 (21%), Positives = 165/410 (40%), Gaps = 29/410 (7%) Query: 73 QELGPIFRYDLGGAGMVCVMLPEDVEK-LQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFL 131 ++ GP+ R ++ V V PE V+K L +M + + + V Sbjct: 21 KKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSE 80 Query: 132 LNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPS 191 N W R R+ S +++ + + A + L+ K A G + +Q Sbjct: 81 CNYERWHKQR-RVIDLAFSRSSLVSLMETFNEKAEQLVEILEAK----ADGQTPVSMQDM 135 Query: 192 IFHYTIEASNLALFGERLGLV--GHSPSSASLNFLHALEVMFKSTVQLM-FMPRSLSRWT 248 + + ++ A FG ++ P S ++ + LE + S L F+P Sbjct: 136 LTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLM--LEGITASRNTLAKFLP------G 187 Query: 249 SPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAE---LSPDAIK 305 K +E E+ + Q G + +Q+ + A R ++ + + +L AE + + Sbjct: 188 KRKQLREVRESIRFLRQVGRDWVQRRRE--ALKRGEEVPADILTQILKAEEGAQDDEGLL 245 Query: 306 ANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLL 365 N + +T+ L T+ EL+R P + L+ E S + L L Sbjct: 246 DNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYL 305 Query: 366 RAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNP 425 LKE+LRLYP R+ + ++ +P T + Y +GR F P +NP Sbjct: 306 SQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNP 365 Query: 426 QRWLDIRGSGR---NFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQ 472 R+ G G F + PF G R C+G++ A+ E+ +++ +L+ L+ Sbjct: 366 DRF----GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLE 411 >3QZ1-A nrPDB Length = 496 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 52/170 (30%), Positives = 80/170 (47%), Gaps = 7/170 (4%) Query: 304 IKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE---SLAAAASISEHPQKATT 360 + + ++L G +TT L + L +P +Q+ L++E L AS S K Sbjct: 280 VHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEELDRELGPGASCSRVTYKDRA 339 Query: 361 ELPLLRAALKETLRLYPV-GLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPR 419 LPLL A + E LRL PV L L + + Y IP G +V L + ++ + Sbjct: 340 RLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGMVVIPNLQGAHLDETVWEQ 399 Query: 420 PERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 P + P R+L+ G N + FG G R CLG LA E+ ++L +L+ Sbjct: 400 PHEFRPDRFLE---PGANPSALAFGCGARVCLGESLARLELFVVLARLLQ 446 >6DWN-A nrPDB Length = 491 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 52/202 (25%), Positives = 92/202 (45%), Gaps = 8/202 (3%) Query: 296 NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHP 355 N +LS + I ++L DT + +L L NP VQ+ + QE L S P Sbjct: 272 NVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKI-QEELDTVIGRSRRP 330 Query: 356 QKAT-TELPLLRAALKETLRLYP-VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRN 413 + + + LP + A + ET R V + + D L+ ++IP G V V + + + Sbjct: 331 RLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHD 390 Query: 414 PALFPRPERYNPQRWLDIRGSGRNFYH---VPFGFGMRQCLGRRLAEAEMLLLLHHVLKH 470 L+ P + P+R+L G+ + FG G R+C+G +A E+ L L +L+ Sbjct: 391 QKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 450 Query: 471 LQ--VETLTQEDIKMVYSFILR 490 ++ V + D+ +Y ++ Sbjct: 451 VEFSVPLGVKVDMTPIYGLTMK 472 >2NNH-A nrPDB Length = 476 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 48/190 (25%), Positives = 87/190 (45%), Gaps = 8/190 (4%) Query: 297 AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQ 356 +E + + + +L +TT L L L ++P V +++E Sbjct: 262 SEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCM 321 Query: 357 KATTELPLLRAALKETLR---LYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRN 413 + + +P A + E R L P G+ ++D +NY IP GT + L S+ + Sbjct: 322 QDRSHMPYTDAVVHEIQRYSDLVPTGV--PHAVTTDTKFRNYLIPKGTTIMALLTSVLHD 379 Query: 414 PALFPRPERYNPQRWLDIRGS-GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQ 472 FP P ++P +LD G+ ++ Y +PF G R C G LA E+ L L +L++ Sbjct: 380 DKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFN 439 Query: 473 VETLTQEDIK 482 ++++ +D+K Sbjct: 440 LKSV--DDLK 447 >3MGX-A nrPDB Length = 415 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 48/191 (25%), Positives = 85/191 (44%), Gaps = 27/191 (14%) Query: 275 YQELAFSRPQQ-YTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARN 333 + EL +R ++ +V+ L+ + +L+ D + N + G +TT + + LA Sbjct: 214 FDELITARRKEPGDDLVSTLVTDDDLTIDDVLLNCDNVLIGGNETTRHAITGAVHALATV 273 Query: 334 PNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQ 393 P + ALR S + ++E LR + + RV ++D+ + Sbjct: 274 PGLLTALRDGSAD------------------VDTVVEEVLRWTSPAMHVLRVTTADVTIN 315 Query: 394 NYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGR 453 +P+GT V +L + R+PA F P+ + P R + H+ FG GM CLG Sbjct: 316 GRDLPSGTPVVAWLPAANRDPAEFDDPDTFLPGR--------KPNRHITFGHGMHHCLGS 367 Query: 454 RLAEAEMLLLL 464 LA E+ ++L Sbjct: 368 ALARIELSVVL 378 >5FOI-A nrPDB Length = 408 Score = 65.1 bits (157), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 53/192 (27%), Positives = 88/192 (45%), Gaps = 26/192 (13%) Query: 288 SIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAA 347 + V E LL E++ + N++ L A +T+ + +++ L R+P Sbjct: 221 TAVTERLLKGEITHQELVNNAVLLLAAGHETSANQVTLSVLTLLRHPET----------- 269 Query: 348 AASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFL 407 AA + E P+ L+ A+ E LR + + L R A++D+VL ++ I AG + + L Sbjct: 270 AAELREQPE-------LMPNAVDELLRYHSIADGLRRAATADIVLGDHTIRAGDGLIILL 322 Query: 408 YSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHV 467 S + F + DI R +HV FG+G QCLG+ LA EM + L + Sbjct: 323 SSANHDGNTF------GAEATFDIHRPAR--HHVAFGYGPHQCLGQNLARLEMEVTLGKL 374 Query: 468 LKHLQVETLTQE 479 + + L QE Sbjct: 375 FRRVPALRLAQE 386 >3SN5-A nrPDB Length = 491 Score = 63.9 bits (154), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 60/245 (24%), Positives = 106/245 (43%), Gaps = 32/245 (13%) Query: 263 IFQYGDNCIQKIYQELAFSRPQQYTSIVA----ELLLNAELSP-DAIKANSMELTA--GS 315 +F+ N +K+ + L Q+ SI + LN LS D ++ L S Sbjct: 210 MFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWAS 269 Query: 316 VDTTVFPLLMTLFELARNPNVQQALRQE------SLAAAASISEHP----QKATTELPLL 365 T+ +LF++ RNP +A +E + S+ +P Q +LP+L Sbjct: 270 QANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVL 329 Query: 366 RAALKETLRLYPVGLFLERVASSDLVLQ----NYHIPAGTLVRVFLYSLGRNPALFPRPE 421 + +KE+LRL L + R A D L +Y+I ++ ++ + +P ++P P Sbjct: 330 DSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPL 388 Query: 422 RYNPQRWLDIRGSGRN----------FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471 + R+LD G + +Y++PFG G C GR A E+ L +L + Sbjct: 389 TFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYF 448 Query: 472 QVETL 476 ++E + Sbjct: 449 ELELI 453 >6IQ5-A nrPDB Length = 463 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 50/207 (24%), Positives = 87/207 (42%), Gaps = 6/207 (2%) Query: 296 NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHP 355 A L + + A ++ S DT L L R P+VQ ++ E Sbjct: 245 GARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPC 304 Query: 356 QKATTELPLLRAALKETLRLYP-VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNP 414 LP + A L E +R V + + +++ + YHIP T+V V +S+ +P Sbjct: 305 MGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDP 364 Query: 415 ALFPRPERYNPQRWLDIRG---SGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471 +P PE ++P R+LD G + F G R+C+G L++ ++ L + + Sbjct: 365 VKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQC 424 Query: 472 QVETLTQEDIKMVYSF--ILRPSMFPL 496 E KM +S+ ++P F + Sbjct: 425 DFRANPNEPAKMNFSYGLTIKPKSFKV 451 >4KPA-A nrPDB Length = 494 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 55/187 (29%), Positives = 87/187 (46%), Gaps = 7/187 (3%) Query: 311 LTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQ-KATTELPLLRAAL 369 L AG +TT L L+ L +NP+V Q +E AA + P K +L + L Sbjct: 286 LIAGH-ETTSGLLSFALYFLVKNPHVLQKAAEE--AARVLVDPVPSYKQVKQLKYVGMVL 342 Query: 370 KETLRLYPVGLFLERVASSDLVLQN-YHIPAGTLVRVFLYSLGRNPALFPRP-ERYNPQR 427 E LRL+P A D VL Y + G + V + L R+ ++ E + P+R Sbjct: 343 NEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPER 402 Query: 428 WLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSF 487 + + ++ + PFG G R C+G++ A E L+L +LKH E T ++ + + Sbjct: 403 FENPSAIPQHAFK-PFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETL 461 Query: 488 ILRPSMF 494 L+P F Sbjct: 462 TLKPEGF 468 >3IBD-A nrPDB Length = 476 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 46/194 (23%), Positives = 85/194 (43%), Gaps = 7/194 (3%) Query: 296 NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHP 355 ++E S + N++ L +TT L + + P+V + + +E Sbjct: 261 HSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPE 320 Query: 356 QKATTELPLLRAALKETLR---LYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGR 412 ++P A + E R L P+G+ + + + Y IP T V + L + Sbjct: 321 LHDRAKMPYTEAVIYEIQRFSDLLPMGV--PHIVTQHTSFRGYIIPKDTEVFLILSTALH 378 Query: 413 NPALFPRPERYNPQRWLDIRGS-GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471 +P F +P+ +NP +LD G+ + +PF G R CLG +A AE+ L +L++ Sbjct: 379 DPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 438 Query: 472 QVET-LTQEDIKMV 484 + + + EDI + Sbjct: 439 SMASPVAPEDIDLT 452 >6AYB-A nrPDB Length = 466 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 42/169 (24%), Positives = 77/169 (45%), Gaps = 3/169 (1%) Query: 326 TLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERV 385 TL + N V + +R+E S ++ L A +KE LR+YP + + R+ Sbjct: 280 TLMNVISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPPLIMIMRM 339 Query: 386 ASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYH--VPF 443 A + Y IP G ++ V GR + P+ ++P+R + R F + VPF Sbjct: 340 ARKPRECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVFDPERLTE-RKEHEKFKYGAVPF 398 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPS 492 G G +C+G A ++ ++ +L++ +E + + S ++ PS Sbjct: 399 GAGRHKCIGENFALLQVKSIISILLRYFDMEYIGKIPDPSYTSLVVGPS 447 >4H1N-A nrPDB Length = 479 Score = 61.6 bits (148), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 48/181 (26%), Positives = 77/181 (42%), Gaps = 7/181 (3%) Query: 309 MELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAA 368 + L A +TT L + + P+V + +++E S ++P A Sbjct: 274 LSLFAAGTETTSTTLRYGFLLMLKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAV 333 Query: 369 LKETLRL---YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNP 425 + E RL P G+ + D + Y IP T V L S +P F P +NP Sbjct: 334 IHEIQRLGDLIPFGV--PHTVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNP 391 Query: 426 QRWLDIRGS-GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVET-LTQEDIKM 483 +LD G+ RN +PF G R CLG +A E+ L +L++ + + + EDI + Sbjct: 392 GHFLDANGALKRNEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDL 451 Query: 484 V 484 Sbjct: 452 T 452 >6GMF-A nrPDB Length = 397 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 56/199 (28%), Positives = 97/199 (48%), Gaps = 23/199 (11%) Query: 303 AIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQK---AT 359 A + + +LTAG V + LL +A N + A ++++HP++ A Sbjct: 210 AAEVDGEKLTAGEVLSFANTLL-----IAGNETTTSLIGN----ALVALTDHPEQLAAAQ 260 Query: 360 TELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPR 419 +L L+ A ++E LR + R +D+ + + IPA ++V L S R+ + FP Sbjct: 261 ADLSLVPAVVEEVLRYESPAQCIFRQTMTDVEIGDERIPARSVVLPLLASANRDESRFPD 320 Query: 420 PERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL-QVETLTQ 478 P+R++ R D +G H+ FG + C+G LA E ++L +L L ++ ++Q Sbjct: 321 PDRFDIHR--DTKG------HLAFGLDIHFCIGAPLARLEAKVMLEVLLARLGDIQRVSQ 372 Query: 479 EDIKMVYSFILR-PSMFPL 496 E + SF +R PS PL Sbjct: 373 E-VSWSPSFFIRSPSTLPL 390 >2HI4-A nrPDB Length = 495 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 48/193 (24%), Positives = 85/193 (44%), Gaps = 17/193 (8%) Query: 310 ELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAAS-----ISEHPQKATTELPL 364 ++ DT + +L L P +Q+ +++E +S+ PQ LP Sbjct: 289 DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQ-----LPY 343 Query: 365 LRAALKETLRLYPVGLF-LERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERY 423 L A + ET R F + + D L ++IP V V + + +P L+ P + Sbjct: 344 LEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEF 403 Query: 424 NPQRWLDIRGSGRNF----YHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQ--VETLT 477 P+R+L G+ N + FG G R+C+G LA+ E+ L L +L+ L+ V Sbjct: 404 RPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGV 463 Query: 478 QEDIKMVYSFILR 490 + D+ +Y ++ Sbjct: 464 KVDLTPIYGLTMK 476 >2RFC-A nrPDB Length = 343 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 39/123 (31%), Positives = 54/123 (43%), Gaps = 10/123 (8%) Query: 351 ISEHPQKATTELPLLRAALKETLRLY-PVGLFLERVASSDLVLQNYHIPAGTLVRVFLYS 409 I E+P L ++ETLR Y P+ R A+ D + N I G V V+L S Sbjct: 204 IDENPDIIDDALKNRSGFVEETLRYYSPIQFLPHRFAAEDSYINNKKIKKGDQVIVYLGS 263 Query: 410 LGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 R+ F P D+ GR H+ FG G+ CLG LA E + L+ +L Sbjct: 264 ANRDETFFDEP---------DLFKIGRREMHLAFGIGIHMCLGAPLARLEASIALNDILN 314 Query: 470 HLQ 472 H + Sbjct: 315 HFK 317 >6B11-A nrPDB Length = 440 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 42/122 (34%), Positives = 62/122 (50%), Gaps = 11/122 (9%) Query: 353 EHP---QKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYS 409 +HP ++ T LL A+ E LR + L R A++D+ + + I AG + L + Sbjct: 297 QHPTAWRELTVNPGLLPGAVDELLRYLSIADGLRRSATADIEIDGHTIRAGDGLVFLLAA 356 Query: 410 LGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 R+ A+F PE + DI S R HV FG+G QCLG+ LA E+ + L VL+ Sbjct: 357 ANRDEAVFSEPEAF------DIHRSARR--HVAFGYGPHQCLGQNLARMELEVALGAVLE 408 Query: 470 HL 471 L Sbjct: 409 RL 410 >5VWS-A nrPDB Length = 393 Score = 58.9 bits (141), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 52/196 (26%), Positives = 85/196 (43%), Gaps = 28/196 (14%) Query: 302 DAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTE 361 + + S+ L AG + TTV + T+ L +P ++A+R + Sbjct: 222 EVVNTASLLLLAGHLTTTVL-IGNTMLCLWDHPEAEKAVRADP----------------- 263 Query: 362 LPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPE 421 L+ AAL+E+LRL L RV + D+ + IPA V ++ S + FP PE Sbjct: 264 -SLIPAALEESLRLRSPFLQAGRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPE 322 Query: 422 RYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVL-KHLQVETLTQED 480 R++ R + H+ FG G+ CLG +L E + L +L + ++ +E Sbjct: 323 RFDLHR--------QTTGHIAFGHGVHFCLGAQLGRLEGRIALERLLGRFTEIHPWPREG 374 Query: 481 IKMVYSFILRPSMFPL 496 I S I S P+ Sbjct: 375 ISFYQSAIFGASRMPV 390 >5E0E-A nrPDB Length = 463 Score = 58.2 bits (139), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 44/193 (22%), Positives = 86/193 (44%), Gaps = 7/193 (3%) Query: 296 NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHP 355 + E + + + L +T+ L + + P+V + +++E S Sbjct: 252 HTEFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPT 311 Query: 356 QKATTELPLLRAALKETLR---LYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGR 412 + T++P A + E R L P+G+ + D + + Y +P T V L S Sbjct: 312 LEDRTKMPYTEAVIYEIQRFSDLIPIGV--PHKVTKDTLFRGYLLPKNTEVYPILSSALH 369 Query: 413 NPALFPRPERYNPQRWLDIRGS-GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471 +P F +P+ +NP +LD G+ ++ +PF G R CLG +A E+ L +L++ Sbjct: 370 DPQYFEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNF 429 Query: 472 QVET-LTQEDIKM 483 + + + +DI + Sbjct: 430 SLSSPVAPKDIDL 442 >2W0A-A nrPDB Length = 455 Score = 58.2 bits (139), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 47/154 (30%), Positives = 70/154 (45%), Gaps = 8/154 (5%) Query: 326 TLFELARNPNVQQAL---RQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382 TL EL R+ + A+ E S+S H A ++P L LKETLRL+P + L Sbjct: 268 TLIELMRHRDAYAAVIDELDELYGDGRSVSFH---ALRQIPQLENVLKETLRLHPPLIIL 324 Query: 383 ERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSG--RNFYH 440 RVA + +Q + I G LV R P FP P + P R+ R + Sbjct: 325 MRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTW 384 Query: 441 VPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE 474 +PFG G +C+G A ++ + +L+ + E Sbjct: 385 IPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFE 418 >5E58-A nrPDB Length = 493 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 45/180 (25%), Positives = 80/180 (44%), Gaps = 7/180 (3%) Query: 309 MELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAA 368 + L +TT L + + P+V + +++E S + T++P A Sbjct: 293 LSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLEDRTKMPYTDAV 352 Query: 369 LKETLR---LYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNP 425 + E R L P+G + D + + Y +P T V L S +P F +P +NP Sbjct: 353 IHEIQRFSDLAPIGA--PHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQYFEQPGTFNP 410 Query: 426 QRWLDIRGS-GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV-ETLTQEDIKM 483 +LD G+ ++ +PF G R CLG +A E+ L +L++ V ++ +DI + Sbjct: 411 DHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSVSSSVAPKDIDL 470 >4WMZ-A nrPDB Length = 539 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 80/356 (22%), Positives = 138/356 (38%), Gaps = 53/356 (14%) Query: 149 LSPNAVQRFLPMV-DAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGE 207 L+ A + ++P++ + V + F + K N R + T+DV + TI ++ +L G+ Sbjct: 158 LTKEAFKSYVPLIAEEVYKYFRDS--KNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGK 215 Query: 208 RLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYG 267 + + +F + + K + F+ P + EH+ D + Sbjct: 216 EM------RAKLDTDFAYLYSDLDKGFTPINFV--------FPNLPLEHYRKRD----HA 257 Query: 268 DNCIQKIYQELAFSRPQ----QYTSIVAELLLNAELSPDAIKANSMELT-------AGSV 316 I Y L R + Q ++ L+ N+ D +K E+ G Sbjct: 258 QKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYK-DGVKMTDQEIANLLIGVLMGGQ 316 Query: 317 DTTVFPLLMTLFELARNPNVQQALRQESLAA-AASISEHPQKATTELPLLRAALKETLRL 375 T+ L LA P+VQQ L +E + E E+PLL +KETLR+ Sbjct: 317 HTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRM 376 Query: 376 YPVGLFLERVASSDLVLQN--YHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRG 433 + L R D+ + N Y IPAG V V FP ++N RW + Sbjct: 377 HHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSA 436 Query: 434 S-----------------GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQ 472 S G + ++PFG G +C+G A ++ +L+ ++ L+ Sbjct: 437 SSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLK 492 >4UBS-A nrPDB Length = 393 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 50/165 (30%), Positives = 76/165 (46%), Gaps = 15/165 (9%) Query: 310 ELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKAT---TELPLLR 366 +L G+VD L TL +A + + + ++ HP++ E L+ Sbjct: 211 QLNRGTVDRAELVSLATLLLIAGHETTANMISLGTF----TLLRHPEQLAELRAEPGLMP 266 Query: 367 AALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQ 426 AA++E LR + L RVA+ D+ + I A V + R+ A F P+ Sbjct: 267 AAVEELLRFLSIADGLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPD----- 321 Query: 427 RWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471 LD S R +HV FGFG+ QCLG+ LA AEM + L + + L Sbjct: 322 -ALDWHRSAR--HHVAFGFGIHQCLGQNLARAEMEIALGTLFERL 363 >3TYW-A nrPDB Length = 417 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 40/133 (30%), Positives = 64/133 (48%), Gaps = 9/133 (6%) Query: 353 EHPQKATTELPLLRAALKETLRLYPVGLFLE-RVASSDLVLQNYHIPAGTLVRVFLYSLG 411 E P + + L+ AA+ E LR+ V + RVA+ D+ L +PA V L Sbjct: 270 ELPAELRKDPDLMPAAVDELLRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGAN 329 Query: 412 RNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471 +P F PER + R + +HV FG+G+ QC+G+ LA E+ + L +L+ + Sbjct: 330 HDPEQFDDPERVDFHRT--------DNHHVAFGYGVHQCVGQHLARLELEVALETLLRRV 381 Query: 472 QVETLTQEDIKMV 484 L E ++V Sbjct: 382 PTLRLAGERDQVV 394 >3JUS-A nrPDB Length = 461 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 51/194 (26%), Positives = 84/194 (43%), Gaps = 17/194 (8%) Query: 311 LTAGSVDTTVFPLLMTLFELARNPNVQQALR-QESLAAAASISEHPQKATTELPLLRAAL 369 L AG ++ M F LAR+ +Q+ ++ ++ +L LL + Sbjct: 261 LLAGQHTSSTTSAWMGFF-LARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCI 319 Query: 370 KETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWL 429 KETLRL P + + R+A + + Y IP G V V R + +NP R+L Sbjct: 320 KETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYL 379 Query: 430 -DIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFI 488 D SG F +VPFG G +C+G A ++Q++T+ +++ Y F Sbjct: 380 QDNPASGEKFAYVPFGAGRHRCIGENFA-------------YVQIKTIWSTMLRL-YEFD 425 Query: 489 LRPSMFPLLTFRAI 502 L FP + + + Sbjct: 426 LIDGYFPTVNYTTM 439 >1WIY-A nrPDB Length = 389 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 40/110 (36%), Positives = 54/110 (49%), Gaps = 7/110 (6%) Query: 369 LKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRW 428 +E LRLYP L R L+L +P GT + + Y R FP E + P+R+ Sbjct: 258 FQEALRLYPPAWILTRRLERPLLLGEDRLPQGTTLVLSPYVTQR--LYFPEGEAFQPERF 315 Query: 429 LDIRG--SGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETL 476 L RG SGR F PFG G R CLGR A E ++L + +++ L Sbjct: 316 LAERGTPSGRYF---PFGLGQRLCLGRDFALLEGPIVLRAFFRRFRLDPL 362 >3RWL-A nrPDB Length = 426 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 59/245 (24%), Positives = 97/245 (39%), Gaps = 33/245 (13%) Query: 242 RSLSRW---TSPKVWKEHFEAWDCIFQYGDNC---IQKIYQELAFSRP-QQYTSIVAELL 294 R L+RW T+ E+WD C Q ++ E P S++A Sbjct: 186 RKLTRWSDVTTAAPGGGVVESWDQRKTELLECAAYFQVLWNERVNKDPGNDLISMLAHSP 245 Query: 295 LNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEH 354 ++P+ N + L G DTT + + L +NP+ A + + Sbjct: 246 ATRNMTPEEYLGNVLLLIVGGNDTTRNSMTGGVLALHKNPD-----------QFAKLKAN 294 Query: 355 PQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNP 414 P T +P E +R + R A +D L I G V ++ YS R+ Sbjct: 295 PALVETMVP-------EIIRWQTPLAHMRRTAIADSELGGKTIRKGDKVVMWYYSGNRDD 347 Query: 415 ALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL-QV 473 + RPE + R R H+ FGFG+ +C+G RLAE ++ +L +L ++ Sbjct: 348 EVIDRPEEFIIDR-------PRPRQHLSFGFGIHRCVGNRLAEMQLRILWEEILTRFSRI 400 Query: 474 ETLTQ 478 E + + Sbjct: 401 EVMAE 405 >3ABA-A nrPDB Length = 403 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 35/109 (32%), Positives = 55/109 (50%), Gaps = 9/109 (8%) Query: 364 LLRAALKETLRLYPVGLFL-ERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPER 422 L+ A++E LR +G F ERVA+ D+ L I G V + + +PA PER Sbjct: 269 LVGNAVEELLRYLTIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPER 328 Query: 423 YNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471 ++ R R H+ FGFG QC+G++LA E+ ++ + + L Sbjct: 329 FDITR--------RPAPHLAFGFGAHQCIGQQLARIELQIVFETLFRRL 369 >2ZBZ-A nrPDB Length = 412 Score = 55.1 bits (131), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 55/217 (25%), Positives = 97/217 (44%), Gaps = 35/217 (16%) Query: 288 SIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAA 347 ++VA+ L N E+ + + + +M L +TT +++ L +P ALR + Sbjct: 218 ALVADQLANGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADR--- 274 Query: 348 AASISEHPQKATTELPLLRAALKETLRLYPVG-LFLERVASSDLVLQNYHIPAGTLVRVF 406 L+ A++E LR + + RVA++D+ ++ I AG V V Sbjct: 275 ---------------SLVPGAVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVV 319 Query: 407 LYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHH 466 R+ ++ P+ LDI S R +H+ FGFG+ QCLG+ LA E+ ++L+ Sbjct: 320 NSIANRDGTVYEDPD------ALDIHRSAR--HHLAFGFGVHQCLGQNLARLELEVILNA 371 Query: 467 VLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN 503 ++ + L V +LRP T + +N Sbjct: 372 LMDRVPTLRLAVP----VEQLVLRPGT----TIQGVN 400 >5IT1-A nrPDB Length = 399 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 35/107 (32%), Positives = 53/107 (49%), Gaps = 9/107 (8%) Query: 364 LLRAALKETLRLYPVGLF-LERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPER 422 L+ A++E LR +G F ERVA+ D + I G V L S +PA PER Sbjct: 269 LIGNAVEELLRYLTIGQFGAERVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPER 328 Query: 423 YNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 ++ R R H+ FGFG QC+G++LA E+ ++ + + Sbjct: 329 FDITR--------RPAPHLAFGFGAHQCIGQQLARIELQIVFGTLFR 367 >3TKT-A nrPDB Length = 450 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 39/126 (30%), Positives = 61/126 (48%), Gaps = 10/126 (7%) Query: 364 LLRAALKETLR-LYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPER 422 LL ++E +R PV F+ R A++D L I AG + + + +PA FP P + Sbjct: 321 LLPGIVEEAIRWTTPVQHFM-RTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRK 379 Query: 423 YNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIK 482 ++P R + H+ FG G QCLG LA EM +LL +L + L E + Sbjct: 380 FDPTRPAN--------RHLAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEPKR 431 Query: 483 MVYSFI 488 + +F+ Sbjct: 432 VNSTFV 437 >5JLC-A nrPDB Length = 515 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 76/353 (21%), Positives = 132/353 (37%), Gaps = 46/353 (13%) Query: 149 LSPNAVQRFLPMV-DAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGE 207 L+ A R++P++ + + + F + K+ +N G +DV S TI ++ +L G+ Sbjct: 140 LTKEAFVRYVPLIAEEIYKYFRNSKNFKINENNSG--IVDVMVSQPEMTIFTASRSLLGK 197 Query: 208 RLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYG 267 + +F + + K + F+ P + EH+ D Q Sbjct: 198 EMR------DKLDTDFAYLYSDLDKGFTPINFV--------FPNLPLEHYRKRDHAQQAI 243 Query: 268 DNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELT-------AGSVDTTV 320 + +E Q ++ EL+ N+ D K E+ G T+ Sbjct: 244 SGTYMSLIKERREKNDIQNRDLIDELMKNSTYK-DGTKMTDQEIANLLIGVLMGGQHTSA 302 Query: 321 FPLLMTLFELARNPNVQQALRQESLAA-AASISEHPQKATTELPLLRAALKETLRLYPVG 379 L LA P+VQ+ L QE + E +PLL +KETLRL+ Sbjct: 303 ATSAWCLLHLAERPDVQEELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPL 362 Query: 380 LFLERVASSDLVLQN--YHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGS--- 434 L R D+ + N Y +P V V FP+P +N RW S Sbjct: 363 HSLFRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSA 422 Query: 435 ---------------GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQ 472 G + ++PFG G +C+G A ++ +L+ ++ ++ Sbjct: 423 AGGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLMSIFIRTMK 475 >6HQG-A nrPDB Length = 425 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 44/163 (26%), Positives = 72/163 (44%), Gaps = 25/163 (15%) Query: 306 ANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLL 365 N + L G DTT + ++ L +NP+ + LR E+P L+ Sbjct: 254 GNLILLIVGGNDTTRNTISGSVLALHQNPDQDRKLR-----------ENPG-------LI 295 Query: 366 RAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNP 425 A + ET+R ++ R A D L I G V ++ S R+ + RP Y Sbjct: 296 PAMVSETIRWQTPLAYMRRRAKRDFELGGKTIREGDKVAMWYVSGNRDEEVIDRPNDY-- 353 Query: 426 QRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVL 468 W++ R H+ FGFG+ +C+G RLAE ++ ++ +L Sbjct: 354 --WIE---RPRVRQHLSFGFGVHRCVGNRLAELQLKIIWEEIL 391 >6F0B-A nrPDB Length = 395 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 47/162 (29%), Positives = 78/162 (48%), Gaps = 27/162 (16%) Query: 311 LTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALK 370 L G DTT + ++L V AL+ E + + EHP++ +PLL ++ Sbjct: 230 LIVGGYDTTASTISLSL--------VSYALQPEKFSV---VHEHPER----IPLL---VE 271 Query: 371 ETLRLYPVG-LFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWL 429 E LR + V L L R+A+ D+ + + AG +V L R+ ++FP P+ + R Sbjct: 272 ELLRYHTVSQLGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDR-- 329 Query: 430 DIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471 + HV FG+G QC+G+ LA E+ + V++ L Sbjct: 330 ------PSVPHVGFGYGPHQCVGQALARVELQEAIPAVIRRL 365 >5FYF-A nrPDB Length = 470 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 39/164 (23%), Positives = 74/164 (45%), Gaps = 8/164 (4%) Query: 325 MTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLER 384 +TL + N + ++ L A +K + L+ + E +R ++ R Sbjct: 301 LTLLIVGGNDTTRNSM-SGGLVAMNEFPREFEKLKAKPELIPNMVSEIIRWQTPLAYMRR 359 Query: 385 VASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFG 444 +A D+ L I G V ++ S R+ F NP +++ R RN H+ FG Sbjct: 360 IAKQDVELGGQTIKKGDRVVMWYASGNRDERKFD-----NPDQFIIDRKDARN--HMSFG 412 Query: 445 FGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFI 488 +G+ +C+G RLAE ++ +L +LK + +E ++ +F+ Sbjct: 413 YGVHRCMGNRLAELQLRILWEEILKRFDNIEVVEEPERVQSNFV 456 >4RM4-A nrPDB Length = 396 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 58/255 (22%), Positives = 108/255 (42%), Gaps = 47/255 (18%) Query: 248 TSPKVWKEHFEAWDCIFQYGDNCIQKIYQ------ELAFSRPQQYTSIVAELLLNAELSP 301 ++PK E EA + D C +++ E ++P+Q + +L+ AE + Sbjct: 167 STPKDKSE--EAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQD---IISILVEAEETG 221 Query: 302 DAIKAN------SMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHP 355 + + ++ L AG+ +TT + ++ + P V + LR HP Sbjct: 222 EKLSGEELIPFCTLLLVAGN-ETTTNLISNAMYSILETPGVYEELRS-----------HP 269 Query: 356 QKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPA 415 + L+ A++E LR L R+A D + + I G +V F+ S R+ A Sbjct: 270 E-------LMPQAVEEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEA 322 Query: 416 LFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK---HLQ 472 F RP ++ +R + H+ FG G+ CLG LA E + L ++ H++ Sbjct: 323 KFDRPHMFDIRRHPN--------PHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHME 374 Query: 473 VETLTQEDIKMVYSF 487 ++T + ++Y Sbjct: 375 CVSITPIENSVIYGL 389 >3EL3-A nrPDB Length = 467 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 33/122 (27%), Positives = 55/122 (45%), Gaps = 1/122 (0%) Query: 371 ETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLD 430 E +RL P L R A ++ L Y IPAG + Y++ R+P + ++P RWL Sbjct: 330 EAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLP 389 Query: 431 IRGSGRNFYHV-PFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFIL 489 R + Y + PF G R+C + A++ L+ + + E + + + L Sbjct: 390 ERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITL 449 Query: 490 RP 491 RP Sbjct: 450 RP 451 >6HQW-A nrPDB Length = 445 Score = 52.4 bits (124), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 82/373 (21%), Positives = 153/373 (41%), Gaps = 44/373 (11%) Query: 109 HRMSLEPWVAYRQHRGHKCGVFLLNGPE-----WRFNRLRLN--PEVLSPNAV-QRFLPM 160 +R+ P+ AY HK + + + PE W++ + + PE + P + +R LPM Sbjct: 69 NRVPDSPYGAYWNVASHKAIMHVESLPELFSSSWQYGGITIGDPPEDVDPQKLAERQLPM 128 Query: 161 VDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSAS 220 A+ R ++ V + ++++ I T + +GER V + Sbjct: 129 FIAMDRPDHTGQRRTVAPAFTPAKMVEMEAEIRRRTASVLDSLPWGERFDWVDKVSIELT 188 Query: 221 LNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQY-GDNCIQKIYQELA 279 L L + +L+ S W E D F + G+ + +Q L Sbjct: 189 TGMLAILFGFPWADRRLLTF---WSDWAGDVELTLARELADTRFGFLGE--MAHYFQRLW 243 Query: 280 FSRPQQYTS-IVAELLLNAE----LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNP 334 +R Q S + +++++E +SP N + L G DTT + + L + P Sbjct: 244 GARMQAPPSGDLISMMIHSEAMNHMSPQEFMGNLVLLIVGGNDTTRNTMSGIVHALDKFP 303 Query: 335 NVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQN 394 + ++ L +++ L+ A++E +R + R A++D L Sbjct: 304 DQRELLERDA------------------SLIPNAVQECIRYVTPLAHMRRTATADTELFG 345 Query: 395 YHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRR 454 I AG V ++ S R+ +F NP + + R + R H+ FG G+ +C+G R Sbjct: 346 NQIKAGEKVILWYISANRDETVFE-----NPDKLMVDRPNARR--HLSFGHGIHRCVGAR 398 Query: 455 LAEAEMLLLLHHV 467 LAE ++ +LL + Sbjct: 399 LAELQLRILLEEM 411 >3R9C-A nrPDB Length = 418 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 29/98 (29%), Positives = 46/98 (46%), Gaps = 8/98 (8%) Query: 367 AALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQ 426 A ++ET+R P + R A DL + + +P G + + L + R+P + P+R++P Sbjct: 291 AVIEETMRYDPPVQLVSRYAGDDLTIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDPD 350 Query: 427 RWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLL 464 R H+ FG G CLG LA E + L Sbjct: 351 RA--------QIRHLGFGKGAHFCLGAPLARLEATVAL 380 >3A1L-A nrPDB Length = 425 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 35/105 (33%), Positives = 51/105 (48%), Gaps = 8/105 (7%) Query: 367 AALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQ 426 AA++E +R P + R A D+ L ++ IP G+ V L S R+PA FP P+ + Sbjct: 289 AAVEELMRYDPPVQAVTRWAYEDIRLGDHDIPRGSRVVALLGSANRDPARFPDPDVLDVH 348 Query: 427 RWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471 R + V FG G+ CLG LA AE + L +L + Sbjct: 349 RAAE--------RQVGFGLGIHYCLGATLARAEAEIGLRALLDGI 385 >5DE9-A nrPDB Length = 410 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 42/134 (31%), Positives = 61/134 (45%), Gaps = 13/134 (9%) Query: 368 ALKETLRLYP--VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNP 425 A+ E LR P + L R+A D+ ++ I AG V V + R+P +FP P+R + Sbjct: 277 AIDELLRWIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDF 336 Query: 426 QRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETL--TQEDIKM 483 +R + HV FGFG C G LA E LL+ VL + L ED+ Sbjct: 337 ERSPN--------PHVSFGFGPHYCPGGMLARLESELLVDAVLDRVPGLKLAVAPEDVPF 388 Query: 484 VYSFILR-PSMFPL 496 ++R P P+ Sbjct: 389 KKGALIRGPEALPV 402 >2XKR-A nrPDB Length = 398 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 61/253 (24%), Positives = 100/253 (39%), Gaps = 31/253 (12%) Query: 243 SLSRWTSPKVWKEHFE-AWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSP 301 L + S V +E F+ D Y D I A + +V+ + LS Sbjct: 158 DLVTFLSSHVSQEDFQITMDAFAAYNDFTRATIAARRADPTDDLVSVLVSSEVDGERLSD 217 Query: 302 DAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTE 361 D + ++ + G +TT L +L RN + L+++ Sbjct: 218 DELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRDP----------------- 260 Query: 362 LPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPE 421 LL A++E LR + RV ++D + AG + + S + A+F PE Sbjct: 261 -SLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPE 319 Query: 422 RYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDI 481 +++ QR + H+ FGFG CLG +LA E+ L+ VL+ L L +D Sbjct: 320 KFDVQRNPN--------SHLAFGFGTHFCLGNQLARLELSLMTERVLRRLPDLRLVADDS 371 Query: 482 KMVYSFILRPSMF 494 + LRP+ F Sbjct: 372 VLP----LRPANF 380 >2FR7-A nrPDB Length = 412 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 49/190 (25%), Positives = 81/190 (42%), Gaps = 28/190 (14%) Query: 283 PQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQ 342 P + + + E++P+ L + +DTTV + ++ LAR P+ LR Sbjct: 220 PGGFGACIHAFSDTGEITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRA 279 Query: 343 ESLAAAASISEHPQKATTELPLLRAALKETLRL-YPVGLFLERVASSDLVLQNYHIPAGT 401 + L R A +E +R PV F R + D+ L I G Sbjct: 280 DP------------------SLARNAFEEAVRFESPVQTFF-RTTTRDVELAGATIGEGE 320 Query: 402 LVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEML 461 V +FL S R+P + P+RY+ R + SG HV FG G+ C+G+ +A E Sbjct: 321 KVLMFLGSANRDPRRWDDPDRYDITR----KTSG----HVGFGSGVHMCVGQLVARLEGE 372 Query: 462 LLLHHVLKHL 471 ++L + + + Sbjct: 373 VVLAALARKV 382 >2IAG-A nrPDB Length = 482 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 47/175 (26%), Positives = 81/175 (46%), Gaps = 25/175 (14%) Query: 332 RNPNVQQALRQE-------SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLER 384 +NP A+R E + + + PQK P+L + L E+LRL F+ R Sbjct: 279 KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-TAAPFITR 337 Query: 385 VASSDLVL-----QNYHIPAGTLVRVFLY-SLGRNPALFPRPERYNPQRWLDIRGS-GRN 437 DL + + +++ G + +F + S R+P ++ PE + R+L+ GS ++ Sbjct: 338 EVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKD 397 Query: 438 FY---------HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKM 483 FY ++P+G G CLGR A + + VL HL +E L D+++ Sbjct: 398 FYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLE-LINADVEI 451 >1UE8-A nrPDB Length = 367 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 32/113 (28%), Positives = 55/113 (48%), Gaps = 8/113 (7%) Query: 368 ALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQR 427 A++E LR P + RV + +++ I G LVRV++ S R+ +F P+ + P R Sbjct: 243 AVEEALRFSPPVMRTIRVTKEKVKIRDQVIDEGELVRVWIASANRDEEVFKDPDSFIPDR 302 Query: 428 WLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED 480 + H+ FG G+ CLG LA E + L K +V+ + +++ Sbjct: 303 TPN--------PHLSFGSGIHLCLGAPLARLEARIALEEFAKKFRVKEIVKKE 347 >4WPZ-A nrPDB Length = 397 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 50/202 (24%), Positives = 84/202 (41%), Gaps = 34/202 (16%) Query: 278 LAFSRPQQYTSIVAELLL----NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARN 333 +A R +++EL+ ++ L+ I A S+ + + +TT + M L L N Sbjct: 192 IAVKRENPADDLISELIAISDGDSTLTEREIIALSIGILSAGHETTANQISMFLVTLLHN 251 Query: 334 PNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPV---GLFLERVASSDL 390 P LR A + A+ E LR P+ G + R+ ++++ Sbjct: 252 PEELDKLRDNREA------------------IPKAVDELLRFVPLTTTGGIIPRLTTAEV 293 Query: 391 VLQNYHI-PAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQ 449 L + PAG +V + + R+P +F ER N R N H+ FG G+ Sbjct: 294 ELSGGQVLPAGAVVLPAVATANRDPEVFEDGERLNVTR--------ENNPHLAFGAGIHH 345 Query: 450 CLGRRLAEAEMLLLLHHVLKHL 471 CLG +LA E+ L +L + Sbjct: 346 CLGAQLARIELQEALGAILDRM 367 >4DO1-A nrPDB Length = 410 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 49/190 (25%), Positives = 80/190 (42%), Gaps = 28/190 (14%) Query: 283 PQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQ 342 P + + + E++PD L + +DTTV + ++ LAR P Q LR Sbjct: 218 PGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRS 277 Query: 343 ESLAAAASISEHPQKATTELPLLRAALKETLRL-YPVGLFLERVASSDLVLQNYHIPAGT 401 + L R A +E +R PV F R + ++ L I G Sbjct: 278 DPT------------------LARNAFEEAVRFESPVQTFF-RTTTREVELGGAVIGEGE 318 Query: 402 LVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEML 461 V +FL S R+P + P+ Y+ R + SG HV FG G+ C+G+ +A E Sbjct: 319 KVLMFLGSANRDPRRWSDPDLYDITR----KTSG----HVGFGSGVHMCVGQLVARLEGE 370 Query: 462 LLLHHVLKHL 471 ++L + + + Sbjct: 371 VMLSALARKV 380 >3ABB-A nrPDB Length = 408 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 41/176 (23%), Positives = 74/176 (42%), Gaps = 26/176 (14%) Query: 289 IVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAA 348 ++A L +L D + ++ L +TTV + + L ++P L ++ A + Sbjct: 218 LIARQLEEGDLDHDEVVMIALVLLVAGHETTVNAIALGALTLIQHPEQIDVLLRDPGAVS 277 Query: 349 ASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLY 408 + +E LR V + R+A D+ + I AG V V + Sbjct: 278 GVV------------------EELLRFTSVSDHIVRMAKEDIEVGGATIKAGDAVLVSIT 319 Query: 409 SLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLL 464 + R+ + P+ ++ +R +HV FG G+ QCLG+ LA AE+ + L Sbjct: 320 LMNRDAKAYENPDIFDARR--------NARHHVGFGHGIHQCLGQNLARAELEIAL 367 >3NC3-A nrPDB Length = 441 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 33/110 (30%), Positives = 55/110 (50%), Gaps = 8/110 (7%) Query: 368 ALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQR 427 A+ ETLR P + R S D V+ I T+V + + R+P F +P+ +N R Sbjct: 305 AIAETLRYKPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHR 364 Query: 428 W-LDIR----GSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQ 472 L I+ G+ R H+ FG G+ C+G A+ E+ ++ + VL ++ Sbjct: 365 EDLGIKSAFSGAAR---HLAFGSGIHNCVGTAFAKNEIEIVANIVLDKMR 411 >2X2N-A nrPDB Length = 475 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 35/156 (22%), Positives = 71/156 (45%), Gaps = 9/156 (5%) Query: 326 TLFELARNPNVQ--QALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 383 ++ L NV+ +ALR+E A ++ + E+P +E++R P L L Sbjct: 289 SMLHLMHPANVKHLEALRKEIEEFPAQLNYN--NVMDEMPFAERCARESIRRDPPLLMLM 346 Query: 384 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF 443 R +D+ + +Y +P G ++ + FP P R++P+R + G+ + F Sbjct: 347 RKVMADVKVGSYVVPKGDIIACSPLLSHHDEEAFPEPRRWDPERDEKVEGA-----FIGF 401 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQE 479 G G+ +C+G++ ++ +L + + L E Sbjct: 402 GAGVHKCIGQKFGLLQVKTILATAFRSYDFQLLRDE 437 >5LIE-A nrPDB Length = 414 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 64/243 (26%), Positives = 98/243 (40%), Gaps = 44/243 (18%) Query: 235 VQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELL 294 V+ F R R T P++ E +A ++ Y I E A S+VA Sbjct: 176 VEPGFDFRGSRRATMPRLNVE--DAGSRLYTYALELIAGKRAEPA----DDMLSVVANAT 229 Query: 295 LNAELSPDAIKANSMEL--------TAGSVDTTVFPLLMTLFELARNPNVQQALRQESLA 346 ++ PDA + EL +AG+ +TT + L LA NP+ Q LR Sbjct: 230 ID---DPDAPALSDAELYLFFHLLFSAGA-ETTRNSIAGGLLALAENPDQLQTLR----- 280 Query: 347 AAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVF 406 ++ LL A++E +R R AS + L I AG V V+ Sbjct: 281 -------------SDFELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVW 327 Query: 407 LYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHH 466 S R+P++F R + ++ R + H+ FG G+ CLG LA E+ +L Sbjct: 328 EGSANRDPSVFDRADEFDITR--------KPNPHLGFGQGVHYCLGANLARLELRVLFEE 379 Query: 467 VLK 469 +L Sbjct: 380 LLS 382 >2Z36-A nrPDB Length = 413 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 32/105 (30%), Positives = 54/105 (51%), Gaps = 9/105 (8%) Query: 368 ALKETLRLYPVGLFL-ERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQ 426 A++E LR + + + R+A+ D+ + I AG V V + S +PA+F P Sbjct: 281 AVEELLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPA----- 335 Query: 427 RWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471 LD+ R +H+ FGFG QCLG+ LA E+ ++ + + + Sbjct: 336 -VLDVERGAR--HHLAFGFGPHQCLGQNLARMELQIVFDTLFRRI 377 >5OFQ-A nrPDB Length = 409 Score = 48.9 bits (115), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 52/222 (23%), Positives = 92/222 (41%), Gaps = 33/222 (14%) Query: 271 IQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANS------MELTAGSVDTTVFPLL 324 +Q ++E+ R Q + LLL AE+ + + + L AG+ +TT + Sbjct: 193 LQGYFKEIIAERQQNKQEDLISLLLEAEIDGEHLTEEEVLGFCILLLVAGN-ETTTNLIT 251 Query: 325 MTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLER 384 + + + +VQ +R++ + L+ ++ETLR YP + R Sbjct: 252 NGVRYMTEDVDVQNEVRRD------------------ISLVPNLVEETLRYYPPIQAIGR 293 Query: 385 VASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFG 444 +A+ D+ L I G V + S R+ A F P+ + R + HV FG Sbjct: 294 IAAEDVELGECKIKRGQQVISWAASANRDSAKFEWPDTFVVHR--------KTNPHVSFG 345 Query: 445 FGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYS 486 FG+ CLG LA E + +L+ + + +K + S Sbjct: 346 FGIHFCLGAPLARMEGKIAFTKLLEKGGFSKVQNQSLKPIDS 387 >4PWV-A nrPDB Length = 446 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 53/233 (22%), Positives = 93/233 (39%), Gaps = 31/233 (13%) Query: 269 NCIQKIYQELAFSRPQQYTSIVAELLLNA-----ELSPDAIKANSMELTAGSVDTTVFPL 323 N I + EL R + T V +L N+ L+ + I N L G +T+ + Sbjct: 220 NEILLYFSELVAERRAKPTEDVISVLANSMVDGKPLTEEVIVLNCYSLILGGDETSRLSM 279 Query: 324 LMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 383 + ++ + P+ + LR + L +A +E LR + Sbjct: 280 IDSVQTFTQYPDQWELLRDGKVT------------------LESATEEVLRWATPAMHFG 321 Query: 384 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF 443 R A +D+ L I AG +V ++ S R+ +F P ++ R + H+ F Sbjct: 322 RRAVTDMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAFDLNRSPN--------KHITF 373 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPL 496 G+G CLG L AE+ LL + + +T E ++ +F+ S P+ Sbjct: 374 GYGPHFCLGAYLGRAEVHALLDALRTYTTGFEITGEPQRIHSNFLTGLSRLPV 426 >5YHJ-A nrPDB Length = 413 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 49/202 (24%), Positives = 89/202 (44%), Gaps = 27/202 (13%) Query: 296 NAELSPDAIKA-NSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEH 354 + EL P+ + A + + +V +V+ +L T+ L + P+V++ + E Sbjct: 221 SGELLPEEVVAVEVLNILRPTVAISVY-VLFTVLALHQFPDVKEQV------------ER 267 Query: 355 PQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNP 414 + + TE ++E R YP +D Y P GTL + LY + Sbjct: 268 GEVSKTEF------VQEVRRFYPFFPVAAARVKTDFEWDGYAFPEGTLTLLDLYGTNHDV 321 Query: 415 ALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE 474 +++ P+R++P R+ D + S NF +P G G R E + +L V++ E Sbjct: 322 SIWTEPDRFDPSRFKDWKESPFNF--IPQGGGDVDFGHRCAGEHVTIAILAQVIELFTKE 379 Query: 475 ---TLTQEDIKMVYSFILRPSM 493 T+ +D+ YSF+ PS+ Sbjct: 380 YAYTVPPQDLS--YSFVDMPSL 399 >4YZR-A nrPDB Length = 405 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 33/115 (28%), Positives = 52/115 (45%), Gaps = 9/115 (7%) Query: 356 QKATTELPLLRAALKETLRLY-PVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNP 414 +K + ++ A++E LR PV + R A D + + I G ++ + + S R+P Sbjct: 265 EKLKQQPEMIATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDP 324 Query: 415 ALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 F PE N R + H+ FGFG+ CLG LA E + +LK Sbjct: 325 NFFENPEILNINRSPN--------RHISFGFGIHFCLGAPLARLEGHIAFKALLK 371 >6GK6-A nrPDB Length = 411 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 39/138 (28%), Positives = 66/138 (47%), Gaps = 12/138 (8%) Query: 364 LLRAALKETLRLY-PVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPER 422 L+ +A++E LR P L R + D+ L +PAG V L + R+P FP P+R Sbjct: 275 LVGSAVEEALRCEGPAELSTIRWSLEDIELFGARVPAGEGVAAGLLAANRDPQHFPDPDR 334 Query: 423 YNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL---QVETLTQE 479 ++ R + H+ FG G+ CLG LA E + +L+ L ++ T T++ Sbjct: 335 FDIGRSPN--------RHIGFGGGIHFCLGAMLARIEAAIAFSTLLRRLPRIELATSTRD 386 Query: 480 DIKMVYSFILRPSMFPLL 497 + + I P+ P++ Sbjct: 387 IVWSEWPTIRGPAAVPVV 404 >2WX2-A nrPDB Length = 473 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 25/119 (21%), Positives = 57/119 (47%), Gaps = 5/119 (4%) Query: 361 ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP 420 E+P ++E++R P L + R+ +++ + +Y +P G ++ + FP P Sbjct: 324 EMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNP 383 Query: 421 ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQE 479 ++P+R + G+ + FG G+ +C+G++ A ++ +L + + L E Sbjct: 384 RLWDPERDEKVDGA-----FIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDE 437 >1CPT-A nrPDB Length = 428 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 52/213 (24%), Positives = 89/213 (41%), Gaps = 33/213 (15%) Query: 290 VAELLLNAELSPDAI-----KANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQES 344 V LL N++L + I A + + DTT + L+RNP E Sbjct: 238 VMSLLANSKLDGNYIDDKYINAYYVAIATAGHDTTSSSSGGAIIGLSRNP--------EQ 289 Query: 345 LAAAASISEHPQKATTELPLLRAALKETLR-LYPVGLFLERVASSDLVLQNYHIPAGTLV 403 LA A S + L+ + E +R PV F+ R A +D ++ +I G + Sbjct: 290 LALAKS----------DPALIPRLVDEAVRWTAPVKSFM-RTALADTEVRGQNIKRGDRI 338 Query: 404 RVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLL 463 + S R+ +F P+ ++ R+ + H+ FG+G CLG+ LA+ EM + Sbjct: 339 MLSYPSANRDEEVFSNPDEFDITRFPN--------RHLGFGWGAHMCLGQHLAKLEMKIF 390 Query: 464 LHHVLKHLQVETLTQEDIKMVYSFILRPSMFPL 496 +L L+ L+ + +F+ P P+ Sbjct: 391 FEELLPKLKSVELSGPPRLVATNFVGGPKNVPI 423 >6GII-A nrPDB Length = 479 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 32/127 (25%), Positives = 57/127 (44%), Gaps = 7/127 (5%) Query: 364 LLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERY 423 L+ AA +E LR R + ++ ++ +P G + + + S + A F PE Sbjct: 340 LIPAAAEECLRYNGPVAGWRRRTTREVEVEGVRLPVGANILMVVASANHDSAHFDDPE-- 397 Query: 424 NPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKM 483 + DI G H+ FG+G QCLGR L EM +++ + + L L ++ Sbjct: 398 ----FFDI-GRSNASEHLNFGYGAHQCLGRNLGRMEMQIMIEELSRRLPHMRLAEQRFDY 452 Query: 484 VYSFILR 490 +++ R Sbjct: 453 LHNVSFR 459 >2WIO-A nrPDB Length = 431 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 36/137 (26%), Positives = 62/137 (45%), Gaps = 9/137 (6%) Query: 350 SISEHPQ--KATTELP-LLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVF 406 ++ EHP A E P + A ++E LR P ++R + + IPA +V + Sbjct: 276 TLDEHPAHWDAAAEDPGRIPAIVEEVLRYRPPFPQMQRTTTKATEVAGVPIPADVMVNTW 335 Query: 407 LYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHH 466 + S R+ P+R++P R SG + FG G+ CLG LA E + L Sbjct: 336 VLSANRDSDAHDDPDRFDPS-----RKSG-GAAQLSFGHGVHFCLGAPLARLENRVALEE 389 Query: 467 VLKHLQVETLTQEDIKM 483 ++ T+ ++D ++ Sbjct: 390 IIARFGRLTVDRDDERL 406 >3OFT-A nrPDB Length = 396 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 55/209 (26%), Positives = 78/209 (37%), Gaps = 44/209 (21%) Query: 265 QYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLL 324 Q GD+ +I E RP D + L G +DT + Sbjct: 200 QPGDDLFSRILSEPVGGRPWTV---------------DEARRMCRNLLFGGLDTVAAMIG 244 Query: 325 MTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLER 384 M LAR+P Q+ LR E P L+ AA E +R YP + + R Sbjct: 245 MVALHLARHPEDQRLLR-----------ERPD-------LIPAAADELMRRYPT-VAVSR 285 Query: 385 VASSDLVLQNYHIPAGTLVRV--FLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVP 442 A +D+ I G LV + L++L +PA F PE R L H Sbjct: 286 NAVADVDADGVTIRKGDLVYLPSVLHNL--DPASFEAPEEVRFDRGL------APIRHTT 337 Query: 443 FGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471 G G +C+G LA E+++ L L + Sbjct: 338 MGVGAHRCVGAGLARMEVIVFLREWLGGM 366 >5YSW-A nrPDB Length = 441 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 58/198 (29%), Positives = 86/198 (43%), Gaps = 38/198 (19%) Query: 282 RPQQYTSIVAELLLNAELSP-----DAIKANSMELTAGSVDTTVFPLLMTLFELARNPNV 336 R I++ L+ +A P + I ++ L AG DTT L + +F L + P Sbjct: 241 RANPAGDIISGLIHHAGADPALTDDELINIANLLLIAG-YDTTASMLGLGIFVLLQRPAQ 299 Query: 337 QQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYH 396 LR + A ++ E LLR L + G+F R A DL H Sbjct: 300 LATLRDDPSRIADAVEE----------LLR-----YLSVVNPGIF--RFAKEDLEFAGEH 342 Query: 397 IPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDI---RGSGRNFYHVPFGFGMRQCLGR 453 IPAG+ V V + + R+ +P P+ LD+ RG H+ FG G+ QCLG+ Sbjct: 343 IPAGSTVVVSVVATNRDARHWPDPD-------LDLTRPRGP-----HLAFGHGVHQCLGQ 390 Query: 454 RLAEAEMLLLLHHVLKHL 471 +LA EM +L+ L Sbjct: 391 QLARMEMQAGYAELLRRL 408 >4TRI-A nrPDB Length = 407 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 31/111 (27%), Positives = 51/111 (45%), Gaps = 8/111 (7%) Query: 361 ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP 420 ++ LL A++E LR + R ++D V + AG + + S + ++F P Sbjct: 262 DVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDP 321 Query: 421 ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471 + + R + HV FGFG CLG +LA E+ L+ VL+ L Sbjct: 322 DNFRIDRNPN--------SHVAFGFGTHFCLGNQLARLELRLMTERVLRRL 364 >5D3U-A nrPDB Length = 427 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 49/190 (25%), Positives = 80/190 (42%), Gaps = 15/190 (7%) Query: 272 QKIYQELAFSRPQQYTSIVAELL--LNAELSPDAI----KANSMELTAGSVDTTVFPLLM 325 Q + QE+ + + +ELL + ++ PD + A LT + + TV L + Sbjct: 203 QPVTQEIILEKLTDLHTYASELLQGMRGKVLPDTVIARLAAAQDGLTETTPEQTVHQLAL 262 Query: 326 TLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERV 385 L P +L +LA A + ++ + + E LR F RV Sbjct: 263 VFIALFA-PTTPGSLSSGTLAFARN-PRQVERFLADQACVDNTANEVLRYNASNQFTWRV 320 Query: 386 ASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGF 445 A+ D+ + I AG + +FL S R+ +F RP ++ LD S R H+ FG Sbjct: 321 AAKDVEMGGVRIEAGQTLALFLGSANRDANMFERPNDFD----LDRPNSAR---HLSFGQ 373 Query: 446 GMRQCLGRRL 455 G+ CL +L Sbjct: 374 GVHACLAAQL 383 >3EJB-B nrPDB Length = 404 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 38/139 (27%), Positives = 62/139 (44%), Gaps = 18/139 (12%) Query: 364 LLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERY 423 L+ A++E LR RVAS D+ + I G V + L + R+P++F P+ + Sbjct: 266 LIGTAVEECLRYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVF 325 Query: 424 NPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKM 483 + R + H+ FG G CLG LA E + ++ +L+ + +L D + Sbjct: 326 DITRSPNP--------HLSFGHGHHVCLGSSLARLEAQIAINTLLQRM--PSLNLADFEW 375 Query: 484 VYSFILRPSMFPLLTFRAI 502 Y PL FRA+ Sbjct: 376 RYR--------PLFGFRAL 386 >6HQD-A nrPDB Length = 420 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 34/130 (26%), Positives = 55/130 (42%), Gaps = 10/130 (7%) Query: 337 QQALRQESLAAAASISEHPQ---KATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQ 393 R +A + +PQ K LL + + E +R + R A D+ + Sbjct: 261 NDTTRSSMSGSAMACHLYPQEFDKVRNNRALLASVIPEVVRWQTPIAHMRRTALEDVEFR 320 Query: 394 NYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGR 453 I G V ++ S R+ + RP + I R +H+ FGFG+ +CLG Sbjct: 321 GKQIRKGDKVVMWYLSGNRDDEVIDRPMDF-------IADRPRARHHLSFGFGIHRCLGN 373 Query: 454 RLAEAEMLLL 463 RLAE ++ +L Sbjct: 374 RLAELQLKIL 383 >2VZM-A nrPDB Length = 436 Score = 45.1 bits (105), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 38/120 (31%), Positives = 54/120 (45%), Gaps = 12/120 (10%) Query: 354 HPQKATT---ELPLLRAALKETLRLY-PVGLFLERVASSDLVLQNYHIPAGTLVRVFLYS 409 HP + ++ LL A++E LR PV R + L IPAG V V L Sbjct: 282 HPDQLAALRADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLAD 341 Query: 410 LGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 R P FP P R++ +R D G H+ FG G+ C+G LA E + + +L+ Sbjct: 342 AHRTPERFPDPHRFDIRR--DTAG------HLAFGHGIHFCIGAPLARLEARIAVRALLE 393 >5XJN-A nrPDB Length = 455 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 36/120 (30%), Positives = 55/120 (45%), Gaps = 10/120 (8%) Query: 353 EHPQK--ATTELP-LLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYS 409 +HP++ A E P L+ AA+ E LR + R A D + I G V + + S Sbjct: 310 DHPEQWQAILENPKLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGS 369 Query: 410 LGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 R+ A F E ++ R + R H+ FGFG+ CLG LA+ + + L V + Sbjct: 370 ANRDEARFENGEEFDISR-----ANARE--HLSFGFGIHYCLGNMLAKLQAKICLEEVTR 422 >6FYJ-A nrPDB Length = 421 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 31/129 (24%), Positives = 56/129 (43%), Gaps = 9/129 (6%) Query: 369 LKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRW 428 ++E R YP F+ + D + Y GTL + LY +P ++ P+ ++P R+ Sbjct: 284 VQEVRRFYPFFPFVVALVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDRF 343 Query: 429 LDIRGSGRNFYHVPFGFG----MRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMV 484 GS +F +P G G +C G + M + L ++ + E Q+ + Sbjct: 344 AKWEGSPFSF--IPQGGGDYFMGHRCAGEWVTIEVMKVSLDYLTNRMDYEVPDQD---LS 398 Query: 485 YSFILRPSM 493 +S PS+ Sbjct: 399 FSMASMPSI 407 >5GWE-A nrPDB Length = 405 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 36/120 (30%), Positives = 55/120 (45%), Gaps = 10/120 (8%) Query: 353 EHPQK--ATTELP-LLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYS 409 +HP++ A E P L+ AA+ E LR + R A D + I G V + + S Sbjct: 260 DHPEQWQAILENPKLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGS 319 Query: 410 LGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 R+ A F E ++ R + R H+ FGFG+ CLG LA+ + + L V + Sbjct: 320 ANRDEARFENGEEFDISR-----ANARE--HLSFGFGIHYCLGNMLAKLQAKICLEEVTR 372 >5Y1I-A nrPDB Length = 403 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 47/194 (24%), Positives = 82/194 (42%), Gaps = 27/194 (13%) Query: 281 SRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQAL 340 R S +A + E++ D M L +TT + + L NP + Sbjct: 204 DRGDDILSDLAVQVEAGEITQDDAAGIGMMLLGAGHETTANMIALGTLALLENPEQLAEV 263 Query: 341 RQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGL-FLERVASSDLVLQNYHIPA 399 R S+ P+ ++ ++E LR + + R+A+ D+ + I A Sbjct: 264 RD---------SDDPK-------VIVNTVEELLRYLTIAQDTVRRIAAEDIEIGGVVIKA 307 Query: 400 GTLVRVFLYSLGRNPALFPR-PERYNPQRWLDI-RGSGRNFYHVPFGFGMRQCLGRRLAE 457 G + L + +P L+P P+R LDI R + R H+ FG+G+ QCLG LA Sbjct: 308 GEGIVFPLNAANWDPDLYPEAPDR------LDIHRANARR--HLAFGYGVHQCLGATLAR 359 Query: 458 AEMLLLLHHVLKHL 471 E+ ++ +L+ + Sbjct: 360 VELQIVYSTLLRRI 373 >4OQS-A nrPDB Length = 433 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 27/77 (35%), Positives = 39/77 (50%), Gaps = 7/77 (9%) Query: 384 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF 443 R A D+ L+ I G V + L ++ R+P +F P+ R +D R H F Sbjct: 289 RAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDR-VDAR------KHAAF 341 Query: 444 GFGMRQCLGRRLAEAEM 460 G G+ QCLG++LA EM Sbjct: 342 GGGIHQCLGQQLARVEM 358 >4OQR-A nrPDB Length = 457 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 27/77 (35%), Positives = 39/77 (50%), Gaps = 7/77 (9%) Query: 384 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF 443 R A D+ L+ I G V + L ++ R+P +F P+ R +D R H F Sbjct: 328 RAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDR-VDAR------KHAAF 380 Query: 444 GFGMRQCLGRRLAEAEM 460 G G+ QCLG++LA EM Sbjct: 381 GGGIHQCLGQQLARVEM 397 >5FSA-A nrPDB Length = 490 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 44/211 (20%), Positives = 83/211 (39%), Gaps = 35/211 (16%) Query: 288 SIVAELLLNAELSPDAIKANSMELTA-------GSVDTTVFPLLMTLFELARNPNVQQAL 340 ++ LL+++ D +K E+ G T+ L L P++Q + Sbjct: 233 DLIDSLLIHSTYK-DGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVI 291 Query: 341 RQESLA----AAASISEHPQKATTELPLLRAALKETLRLY-PVGLFLERVASSDLVLQ-N 394 QE + +++ + +LP + +KETLR++ P+ +V + + + N Sbjct: 292 YQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETN 351 Query: 395 YHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRW---------LDIRGSGRNFY------ 439 Y +P G V V + F PE ++P RW + S Y Sbjct: 352 YIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVS 411 Query: 440 ------HVPFGFGMRQCLGRRLAEAEMLLLL 464 ++PFG G +C+G + A ++ +L Sbjct: 412 KGVSSPYLPFGGGRHRCIGEQFAYVQLGTIL 442 >5H1Z-A nrPDB Length = 407 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 29/102 (28%), Positives = 51/102 (50%), Gaps = 7/102 (6%) Query: 368 ALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQR 427 ++E +R + R A+ D L+ I AG + ++ S R+ ++F N R Sbjct: 281 TVQEIIRWQTPLAHMRRTATVDSELEGQQIKAGDKLALWYISANRDESVFE-----NADR 335 Query: 428 WLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 + R + R H+ FG G+ +C+G RLAE ++ +LL + K Sbjct: 336 IIVDRPNARR--HLAFGHGIHRCVGARLAELQIAVLLEEMAK 375 >2ZQJ-A nrPDB Length = 417 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 20/62 (32%), Positives = 31/62 (50%) Query: 369 LKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRW 428 ++E R YP G FL + D V N GT V + LY +P L+ P+ + P+R+ Sbjct: 280 VQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEFRPERF 339 Query: 429 LD 430 + Sbjct: 340 AE 341 >2Y5N-A nrPDB Length = 417 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 34/110 (30%), Positives = 51/110 (46%), Gaps = 10/110 (9%) Query: 364 LLRAALKETLRLYP--VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPE 421 L+ +A++E R P VG R A D+ L+ I AG V + R+ A FP + Sbjct: 286 LIPSAVEELTRWVPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDAD 345 Query: 422 RYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471 R + R + H+ FG G+ CLG LA E+ + L +L+ L Sbjct: 346 RIDVDRTPN--------QHLGFGHGVHHCLGAPLARVELQVALEVLLQRL 387 >4GGV-A nrPDB Length = 418 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 33/117 (28%), Positives = 52/117 (44%), Gaps = 8/117 (6%) Query: 357 KATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPAL 416 K + L+ A++E LR+ L R S ++ + IP +V ++L + R+P Sbjct: 282 KVRADRSLVPGAIEEALRVLSPSAALARGTSREVEVAGTVIPKDQIVMLWLGAGNRDPRQ 341 Query: 417 FPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV 473 F PE Y+P R + H FG G+ CLG LA E + L+ + V Sbjct: 342 FTDPEVYDPTRDPN--------PHFGFGRGIHFCLGAPLARLEGRVALNALFDRFPV 390 >5CJE-A nrPDB Length = 393 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 45/175 (25%), Positives = 72/175 (41%), Gaps = 27/175 (15%) Query: 296 NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHP 355 + LS + ++A + L +TTV + + L +P+ ALR Sbjct: 215 DDRLSGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAALR-------------- 260 Query: 356 QKATTELPLLRAALKETLRLY-PVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNP 414 ++ LL A++E LR PV R A+ + + I G V + L + GR+P Sbjct: 261 ----ADMTLLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIAEGDPVMIGLDAAGRDP 316 Query: 415 ALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 A P P ++ R H+ FG G+ CLG LA E + L +L+ Sbjct: 317 ARHPDPHVFDIHRA--------PQGHLAFGHGIHYCLGAPLARLEARVALRSLLE 363 >3A50-A nrPDB Length = 411 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 61/266 (22%), Positives = 109/266 (40%), Gaps = 49/266 (18%) Query: 210 GLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIF----- 264 GL+ P+ ++ + E F+ VQ++ L P ++ F AW + Sbjct: 124 GLLAGLPTDGPVDLMR--EYAFQIPVQVICELLGL-----PAEDRDDFSAWSSVLVDDSP 176 Query: 265 -QYGDNCIQKIYQELAF----SRPQQYTSIVAELLLNAELSPDAIK-----ANSMELTAG 314 + + K++ L+ R + ++++ LL +++ D + A +M L Sbjct: 177 ADDKNAAMGKLHGYLSDLLERKRTEPDDALLSSLLAVSDMDGDRLSQEELVAMAMLLLIA 236 Query: 315 SVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLR 374 +TTV + + L +P+ ++ L +E P L+ +A++E LR Sbjct: 237 GHETTVNLIGNGVLALLTHPDQRKLL-----------AEDPS-------LISSAVEEFLR 278 Query: 375 L-YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRG 433 PV R + D+ IPAG +V + L + R+ P P+R + R Sbjct: 279 FDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITR----DA 334 Query: 434 SGRNFYHVPFGFGMRQCLGRRLAEAE 459 SG F FG G+ CLG +LA E Sbjct: 335 SGGVF----FGHGIHFCLGAQLARLE 356 >2WIY-A nrPDB Length = 394 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 52/227 (22%), Positives = 89/227 (39%), Gaps = 43/227 (18%) Query: 290 VAELLLNAELSPDAIKANSM-------ELTAGSVDTTVFP-----------LLMTLFEL- 330 VAE+L + ++P A+S+ E+T T+ L+ + EL Sbjct: 190 VAEMLEDKRVNPGDGLADSLLDAARAGEITESEAIATILVFYAVGHMAIGYLIASGIELF 249 Query: 331 ARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDL 390 AR P V A R + A AA I+E +R+ P L R + D+ Sbjct: 250 ARRPEVFTAFRNDESARAAIINE------------------MVRMDPPQLSFLRFPTEDV 291 Query: 391 VLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQC 450 + I AG+ +R + + R+P +F P+ ++ R + RN FG G C Sbjct: 292 EIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHTR---PPAASRNLS---FGLGPHSC 345 Query: 451 LGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLL 497 G+ ++ AE + + + + L +E F R P++ Sbjct: 346 AGQIISRAEATTVFAVLAERYERIELAEEPTVAHNDFARRYRKLPIV 392 >1Z8P-A nrPDB Length = 404 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 30/92 (32%), Positives = 45/92 (48%), Gaps = 8/92 (8%) Query: 368 ALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQR 427 A++E LR R A+ ++ + IP + V V + R+P FP P R++ R Sbjct: 277 AVEEILRYIAPPETTTRFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFPDPHRFDVTR 336 Query: 428 WLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAE 459 D RG H+ FG G+ C+GR LA+ E Sbjct: 337 --DTRG------HLSFGQGIHFCMGRPLAKLE 360 >6CVC-A nrPDB Length = 433 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 47/241 (19%), Positives = 98/241 (40%), Gaps = 23/241 (9%) Query: 257 FEAWDCIFQYGDNCIQKIYQE---LAFSRPQQYTSIVAELLLN--AELSPDAIKANSMEL 311 F + I +GD + + E ++ + T++ + +N +L+ ++A E+ Sbjct: 195 FHWTNVILGFGDPDLTTDFDEFLQVSMAIGGYATALADDRRVNHHGDLTTSLVEA---EV 251 Query: 312 TAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKE 371 + ++ + L +A N + A+ LA + E + + L A++E Sbjct: 252 DGERLSSSEIAMFFILLVVAGNETTRNAISHGMLALSRYPDERAKWWSDFDGLAATAVEE 311 Query: 372 TLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERY----NPQR 427 +R +++ R S D+ L+ + AG V ++ S R+ F P + NP Sbjct: 312 IVRWASPVVYMRRTLSQDVDLRGTKMAAGDKVTLWYCSANRDEEKFADPWTFDVTRNPNP 371 Query: 428 WLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSF 487 + G G +F CLG LA E+ ++ + + + T+E +++ F Sbjct: 372 QVGFGGGGAHF-----------CLGANLARREIRVVFDELRRQMPDVVATEEPARLLSQF 420 Query: 488 I 488 I Sbjct: 421 I 421 >3L4D-A nrPDB Length = 453 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 26/116 (22%), Positives = 50/116 (43%), Gaps = 4/116 (3%) Query: 361 ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP 420 E+P +E++R P + L R + + Y +P G ++ ++ FP P Sbjct: 310 EMPFAEQCARESIRRDPPLVMLMRKVLKPVQVGKYVVPEGDIIACSPLLSHQDEEAFPNP 369 Query: 421 ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETL 476 +NP+R + + FG G+ +C+G + ++ +L VL+ E L Sbjct: 370 REWNPERNMKLVDGA----FCGFGAGVHKCIGEKFGLLQVKTVLATVLRDYDFELL 421 >5HDI-A nrPDB Length = 404 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 47/174 (27%), Positives = 74/174 (42%), Gaps = 27/174 (15%) Query: 302 DAIKANSMELT--AGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKAT 359 D + A M +T A ++T L ++ LA P++QQ +R +P+ Sbjct: 230 DTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQVRA-----------NPE--- 275 Query: 360 TELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPR 419 LL A ++ETLR P R + L +PA + + + + R+PA F Sbjct: 276 ----LLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEA 331 Query: 420 PERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV 473 P + LD R G+ H+ FG G C+G LA E ++L +L V Sbjct: 332 PGEFR----LD-RAGGKG--HISFGKGAHFCVGAALARLEARIVLRLLLDRTSV 378 >4Z5P-A nrPDB Length = 400 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 32/108 (29%), Positives = 50/108 (46%), Gaps = 10/108 (9%) Query: 364 LLRAALKETLRLYPVGLFL--ERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPE 421 LL A++E LR P+G + R+A D+ L + AG V + R+P F P+ Sbjct: 269 LLPRAVEELLRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPD 328 Query: 422 RYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 R + R H+ FG G CLG +LA E+ + + +L+ Sbjct: 329 RLDITR--------EKNPHLAFGHGAHYCLGAQLARMELRVAIGGLLE 368 >1LG9-A nrPDB Length = 398 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 27/77 (35%), Positives = 34/77 (44%), Gaps = 8/77 (10%) Query: 384 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF 443 R+A DL L I G V L + R+PAL P +R + R HV F Sbjct: 289 RIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLDVTR--------EPIPHVAF 340 Query: 444 GFGMRQCLGRRLAEAEM 460 G G+ CLG LA E+ Sbjct: 341 GHGVHHCLGAALARLEL 357 >6CR2-A nrPDB Length = 477 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 39/150 (26%), Positives = 61/150 (40%), Gaps = 20/150 (13%) Query: 327 LFELARNPNVQQALRQESLAAAAS-ISEHPQKATTELPLLRAALKETLRLY-PVGLFLER 384 + LA P++ + L QE + S + +L L +KETLRL+ P+ + Sbjct: 274 VLRLATRPDIMEELYQEQIRVLGSDLPPLTYDNLQKLDLHAKVIKETLRLHAPIHSIIRA 333 Query: 385 VASSDLVL-QNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLD------------- 430 V + V +Y IP V R+ FP P +NP RW + Sbjct: 334 VKNPMAVDGTSYVIPTSHNVLSSPGVTARSEEHFPNPLEWNPHRWDENIAASAEDDEKVD 393 Query: 431 ----IRGSGRNFYHVPFGFGMRQCLGRRLA 456 + G N ++PFG G +C+G + A Sbjct: 394 YGYGLVSKGTNSPYLPFGAGRHRCIGEQFA 423 >5HH3-A nrPDB Length = 397 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 29/75 (38%), Positives = 40/75 (53%), Gaps = 11/75 (14%) Query: 384 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPE-RYNPQRWLDIRGSGRNFYHVP 442 RVA+ D+ + ++ I AG V L + R FPRPE R++ R +R H+ Sbjct: 291 RVATDDVRIGDHLIKAGDTVTCSLLAANRRN--FPRPEDRFDITR---VRPE-----HLA 340 Query: 443 FGFGMRQCLGRRLAE 457 FG G+ CLGR LAE Sbjct: 341 FGHGIHHCLGRSLAE 355 >5L94-A nrPDB Length = 410 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 30/108 (27%), Positives = 48/108 (44%), Gaps = 8/108 (7%) Query: 361 ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP 420 E LL + ++E LR L R+ D+ L + AG V ++ S R+ F P Sbjct: 271 EKELLPSGIEEVLRYRSPVQALHRIVKEDVTLAGKKLKAGEHVVPWMGSAHRDAEYFEDP 330 Query: 421 ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVL 468 E + R ++ H+ FG G+ CLG LA E ++L ++ Sbjct: 331 EVFKIDRKPNV--------HMAFGRGIHFCLGAPLARIEAKIMLAELI 370 >1UED-A nrPDB Length = 406 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 66/307 (21%), Positives = 117/307 (38%), Gaps = 33/307 (10%) Query: 197 IEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEH 256 +E + +L +RL L+ SA L L A V + +L+ +PR R ++ + Sbjct: 124 MEPAIQSLIDDRLDLLEAEGPSADLQGLFADPVGAHALCELLGIPRDDQREFVRRIRRNA 183 Query: 257 FEAWDCIFQYGDNCIQKIYQE--LAFSRPQQYTSIVAELLLN--AELSPDAIKANSMELT 312 + + D+ Y + LA R ++ ++ + ++ + +K L Sbjct: 184 DLSRGLKARAADSAAFNRYLDNLLARQRADPDDGLLGMIVRDHGDNVTDEELKGLCTALI 243 Query: 313 AGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKET 372 G V+T + + L NP + L E P+KA + E Sbjct: 244 LGGVETVAGMIGFGVLALLDNPGQIELL-----------FESPEKAER-------VVNEL 285 Query: 373 LR-LYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDI 431 +R L PV R+A D+V+ I AG V + R+ AL P P+ + R Sbjct: 286 VRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDPDVLDANRAA-- 343 Query: 432 RGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQ--EDIKMVYSFIL 489 V FG G+ C+G LA + + + + + L E++K +F+ Sbjct: 344 ------VSDVGFGHGIHYCVGAALARSMLRMAYQTLWRRFPGLRLAVPIEEVKYRSAFVD 397 Query: 490 RPSMFPL 496 P P+ Sbjct: 398 CPDQVPV 404 >1F4U-A nrPDB Length = 368 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 32/115 (27%), Positives = 51/115 (44%), Gaps = 9/115 (7%) Query: 368 ALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQR 427 A++E LR P + R + L + I G VRV++ S R+ +F E++ P R Sbjct: 243 AIEEALRYSPPVMRTVRKTKERVKLGDQTIEEGEYVRVWIASANRDEEVFHDGEKFIPDR 302 Query: 428 WLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQ-VETLTQEDI 481 + H+ FG G+ CLG LA E + + K + +E L E + Sbjct: 303 NPNP--------HLSFGSGIHLCLGAPLARLEARIAIEEFSKRFRHIEILDTEKV 349 >3P3Z-A nrPDB Length = 416 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 41/151 (27%), Positives = 71/151 (47%), Gaps = 27/151 (17%) Query: 311 LTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALK 370 L AG +TT L + +++ A++P+ Q ++ I E+P+ L A++ Sbjct: 251 LVAG-YETTNHQLALAMYDFAQHPD--QWMK---------IKENPE-------LAPQAVE 291 Query: 371 ETLRLYP-VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWL 429 E LR P + + RVA+ D + IP GT V + + R+P +F +R++ + Sbjct: 292 EVLRWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFADADRFD----I 347 Query: 430 DIRGSGRNFYHVPFGFGMRQCLGRRLAEAEM 460 ++ R + FG G CLG LA E+ Sbjct: 348 TVK---REAPSIAFGGGPHFCLGTALARLEL 375 >5M0P-A nrPDB Length = 428 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 32/125 (25%), Positives = 51/125 (40%), Gaps = 13/125 (10%) Query: 358 ATTELPLLRAALK-----------ETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVF 406 A E P+ R +K E R YP FL A D+ Q IPAG + + Sbjct: 266 AMNENPITREKIKSEPDYAYKFAQEVRRYYPFVPFLPGKAKVDIDFQGVTIPAGVGLALD 325 Query: 407 LYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHH 466 +Y + +L+ P + P+R+ GS F +P G G R E ++++ Sbjct: 326 VYGTTHDESLWDDPNEFRPERFETWDGS--PFDLIPQGGGDYWTNHRCAGEWITVIIMEE 383 Query: 467 VLKHL 471 +K+ Sbjct: 384 TMKYF 388 >5EX6-C nrPDB Length = 434 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 40/136 (29%), Positives = 55/136 (40%), Gaps = 25/136 (18%) Query: 325 MTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLER 384 + + L RNP ALR + AA ++ E L+R T+ P R Sbjct: 283 LGVLALLRNPEQIAALRGDVPAAERAVDE----------LIRYL---TVPYAPT----PR 325 Query: 385 VASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFG 444 A D + + I AG V L + R+PAL P +R + R HV FG Sbjct: 326 TAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDADRLDVTR--------EAVPHVAFG 377 Query: 445 FGMRQCLGRRLAEAEM 460 G+ CLG LA E+ Sbjct: 378 HGVHHCLGAALARLEL 393 >2NZA-A nrPDB Length = 413 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 32/106 (30%), Positives = 48/106 (45%), Gaps = 10/106 (9%) Query: 368 ALKETLRL--YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNP 425 AL E LR + + L R+A D+ + I AG V V + R+P +FP P+R + Sbjct: 280 ALDELLRWISHRTSVGLARIALEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDL 339 Query: 426 QRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471 R H+ +G G C G LA + LL+ +L+ L Sbjct: 340 DR--------DPNPHLAYGNGHHFCTGAVLARMQTELLVDTLLERL 377 >5L1U-A nrPDB Length = 401 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 56/238 (23%), Positives = 91/238 (38%), Gaps = 41/238 (17%) Query: 250 PKVWKEHFEAWD-CIFQYGDN---------CIQKIYQELAFSRPQQYTSIVAELLL--NA 297 P +E F W F DN + + + +A R + I++EL+ + Sbjct: 159 PLADRERFGQWARGTFDQSDNEHSANTFQQVVDYMLELVARKRVEPGDDILSELIAEKDG 218 Query: 298 ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQK 357 LS I + +TT+ + + L RNP VQ+A ++E P Sbjct: 219 ALSDADIAHLGNAVLLFGYETTIVRIDLGTLLLLRNP-VQRA----------QLAEDPGL 267 Query: 358 ATTELPLLRAALKETLRLYPVG----LFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRN 413 A AA++E LRL G + R A D+ + I G V + + + + Sbjct: 268 AP-------AAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYD 320 Query: 414 PALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471 FP ++ R R H+ FG G R C+GR LA E+ + + + L Sbjct: 321 DRAFPDGGLFDLTRV-------RPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRL 371 >6G5O-A nrPDB Length = 399 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 41/177 (23%), Positives = 74/177 (41%), Gaps = 31/177 (17%) Query: 293 LLLNAE-----LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAA 347 +LLN+E L+ + +K + AG DT + + ++ LA +P + LR+E Sbjct: 194 VLLNSEFEGRKLTKEEVKGVMVLTFAGGRDTVINAVTNSIAYLAEHPEALERLRKE---- 249 Query: 348 AASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFL 407 P+ + A++E +R + + RV + D + + + A + + + Sbjct: 250 -------PE-------ITGRAVEEMIRYFSPLTQMGRVVTEDTHVCEHAVKADSRISLCW 295 Query: 408 YSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLL 464 S R+ A+F P R ++ HV FGF CLG A + +LL Sbjct: 296 ASANRDAAVFENPNEIVLDRKVNP--------HVGFGFSHHNCLGATHARQILKILL 344 >6G71-A nrPDB Length = 405 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 40/144 (27%), Positives = 70/144 (48%), Gaps = 16/144 (11%) Query: 364 LLRAALKETLR-LYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPER 422 L A +E++R + P+G+ + R D L Y IP G + + + S R+ +++ P+R Sbjct: 268 LWGAVFEESIRWVAPIGM-VPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWSDPDR 326 Query: 423 YNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEM----LLLLHHVLKHLQVETLTQ 478 ++ + RGS H+ FG G+ CLG A +++ L L LK L+++ Q Sbjct: 327 FDIE-----RGSE---AHLAFGKGVHVCLGAWAARSQVADVGLPALFSRLKGLRLDP-NQ 377 Query: 479 EDIKMVYSFILRPSMFPLLTFRAI 502 E + F P PL+ +A+ Sbjct: 378 EATHGGWVF-RGPLSLPLVWDKAV 400 >3NV6-A nrPDB Length = 452 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 51/232 (21%), Positives = 94/232 (40%), Gaps = 34/232 (14%) Query: 264 FQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSV-----DT 318 + G+N + +R + L++N+E++ + I + + + DT Sbjct: 235 LEAGNNGFYAYVDPIIRARVGGDGDDLITLMVNSEINGERIAHDKAQGLISLLLLGGLDT 294 Query: 319 TVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPV 378 V L + LAR+P + LR + L L+R A +E R +PV Sbjct: 295 VVNFLSFFMIHLARHPELVAELRSDPLK-----------------LMRGA-EEMFRRFPV 336 Query: 379 GLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRW-LDIRGSGRN 437 + R+ + D + + G ++ + G + A NP+ W LD S R+ Sbjct: 337 -VSEARMVAKDQEYKGVFLKRGDMILLPTALHGLDDAA-------NPEPWKLDF--SRRS 386 Query: 438 FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFIL 489 H FG G +C G LA E+++ L LK + + + + + +S I+ Sbjct: 387 ISHSTFGGGPHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEGETPIYHSGIV 438 >4XE3-A nrPDB Length = 407 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 31/100 (31%), Positives = 47/100 (47%), Gaps = 12/100 (12%) Query: 364 LLRAALKETLRLYPV---GLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP 420 L+ AA++E LR P+ G F+ RVA+ D+ L + AG V S R+ +F Sbjct: 276 LVPAAVEEMLRYTPLVSAGSFV-RVATEDVELSTVTVRAGEPCVVHFASANRDEEVFDHA 334 Query: 421 ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEM 460 + + R RN H+ FG G C+G +L E+ Sbjct: 335 DELDFHRE-------RN-PHIAFGHGAHHCIGAQLGRLEL 366 >4MM0-A nrPDB Length = 399 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 33/126 (26%), Positives = 55/126 (43%), Gaps = 13/126 (10%) Query: 364 LLRAALKETLRLYPVG---LFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP 420 LL +A++E +R P G LF RV D+ + + HIPA + V + +P F P Sbjct: 268 LLPSAVEELMRYAPAGDGALF--RVTLEDVTIGDTHIPANSAVLASTQAANWDPRRFDDP 325 Query: 421 ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED 480 +R + H G G+ CLG LA E+ + + +L+ L ++ Sbjct: 326 T--------GLRLDRPDNQHTALGHGIHFCLGAALARVELQVAIGALLRRFPRLALATDE 377 Query: 481 IKMVYS 486 + +S Sbjct: 378 SGLRWS 383 >2WM5-A nrPDB Length = 435 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 29/125 (23%), Positives = 54/125 (43%), Gaps = 15/125 (12%) Query: 368 ALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERY---- 423 A++E +R +++ R + D+ L+ + AG V ++ S R+ + F P + Sbjct: 311 AVEEIVRWASPVVYMRRTLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLAR 370 Query: 424 NPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKM 483 NP L G G +F CLG LA E+ + + + + T+E ++ Sbjct: 371 NPNPHLGFGGGGAHF-----------CLGANLARREIRVAFDELRRQMPDVVATEEPARL 419 Query: 484 VYSFI 488 + FI Sbjct: 420 LSQFI 424 >5NWS-A nrPDB Length = 435 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 27/86 (31%), Positives = 40/86 (46%), Gaps = 4/86 (4%) Query: 384 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF 443 R A+ DL L + G V++ L S +P + P+R + R G+ HV F Sbjct: 320 RYATEDLELAGTPVARGDAVQLVLVSANFDPRHYSDPDRLDITR----HQEGQAENHVGF 375 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLK 469 G G+ CLG LA E + L +L+ Sbjct: 376 GHGIHYCLGATLARQEGEVALARLLE 401 >3WVS-A nrPDB Length = 401 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 33/121 (27%), Positives = 54/121 (44%), Gaps = 10/121 (8%) Query: 353 EHPQKATTELPLLRAALKETLRLYPVGL--FLERVASSDLVLQNYHIPAGTLVRVFLYSL 410 +H ++ + L+ +A++E R P+G R A D+ + + AG V V L + Sbjct: 262 QHWKRLLDDPELIPSAVEELFRFVPLGSGSAAPRYAREDIEVGGTLVRAGEPVLVALGAA 321 Query: 411 GRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKH 470 R+ F PE R + +H+ FG G+ CLG LA E+ L +L+ Sbjct: 322 NRDGLRFEDPEEIKLDR--------PSNHHIGFGHGIHHCLGAPLARLELQEALRALLER 373 Query: 471 L 471 L Sbjct: 374 L 374 >1GWI-A nrPDB Length = 411 Score = 38.1 bits (87), Expect = 0.009, Method: Compositional matrix adjust. Identities = 36/118 (30%), Positives = 54/118 (45%), Gaps = 12/118 (10%) Query: 347 AAASISEHPQKATTELP---LLRAALKETLRL-YPVGLFLERVASSDLVLQNYHIPAGTL 402 A ++S HP++ L A ++ETLR P L R A+ D+ + + IPAG Sbjct: 254 AVVNLSTHPEQRALVLSGEAEWSAVVEETLRFSTPTSHVLIRFAAEDVPVGDRVIPAGDA 313 Query: 403 VRVFLYSLGRNP-ALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAE 459 + V +LGR+ A P +R++ R R H+ FG G C G L+ E Sbjct: 314 LIVSYGALGRDERAHGPTADRFDLTRTSGNR-------HISFGHGPHVCPGAALSRME 364 >4YT3-A nrPDB Length = 410 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 58/249 (23%), Positives = 95/249 (38%), Gaps = 39/249 (15%) Query: 229 VMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTS 288 ++FK V +F+P R +V K A +QY +Y + R Sbjct: 163 LLFKKWVDTLFLP--FDREKQEEVDKLKQVAAKEYYQY-------LYPIVVQKRLNPADD 213 Query: 289 IVAELL---LNAEL-SPDAIKANSMELTAGSVDTTVFPLLMTLFEL-ARNPNVQQALRQE 343 I+++LL ++ E+ + D + +M + V+TT L + + L + V Q L + Sbjct: 214 IISDLLKSEVDGEMFTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHEN 273 Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLV 403 L L+ A++E LR + L+R D L + G V Sbjct: 274 ------------------LDLVPQAVEEMLRFRFNLIKLDRTVKEDNDLLGVELKEGDSV 315 Query: 404 RVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLL 463 V++ + + +F P N R N H+ FG G CLG LA E + Sbjct: 316 VVWMSAANMDEEMFEDPFTLNIHR-------PNNKKHLTFGNGPHFCLGAPLARLEAKIA 368 Query: 464 LHHVLKHLQ 472 L LK + Sbjct: 369 LTAFLKKFK 377 >5LIV-A nrPDB Length = 450 Score = 36.6 bits (83), Expect = 0.023, Method: Compositional matrix adjust. Identities = 54/250 (21%), Positives = 101/250 (40%), Gaps = 46/250 (18%) Query: 228 EVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYT 287 E + ++ ++ M R L R P E A+ +++ ++ + Sbjct: 196 EKLHETDERVRAMLRGLVRMHDPAAVAESQRAYGETLGLITEVVERESRDTS-------D 248 Query: 288 SIVAELL--LNAELSPDAIKANS---MELTAGSVDTTVFPLLMTLFELARNPNVQQALRQ 342 +++ E+L L AE D I+A+ + L G +TT + + T+ L +P+ +RQ Sbjct: 249 TLLGEILRTLKAE-HMDTIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQ 307 Query: 343 ESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTL 402 + LL AA++E +R P + R+ D+ L + + AGT+ Sbjct: 308 DP------------------SLLPAAIEEGMRWCPSSFGVLRMVERDVRLDDQALSAGTV 349 Query: 403 VRVFLYSLGRNPALFPRPERYNPQR----WLDIRGSGRNFYHVPFGFGMRQCLGRRLAEA 458 V + + + +P PE Y+ R ++ G G +F C+G LA Sbjct: 350 VCLAGIAGNYDETAYPSPEVYDIDRKPLPAANVFGGGAHF-----------CVGAPLARM 398 Query: 459 EMLLLLHHVL 468 E + L +L Sbjct: 399 EARVGLQALL 408 >5XW2-A nrPDB Length = 419 Score = 36.6 bits (83), Expect = 0.025, Method: Compositional matrix adjust. Identities = 34/121 (28%), Positives = 54/121 (44%), Gaps = 10/121 (8%) Query: 350 SISEHPQKATTELPLLRAALKETLR-LYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLY 408 S E + + L+ L+E++R L PV R + D+ + + A +V V+ Sbjct: 274 SYPEQAARVRADRSLIPGLLEESMRFLSPVAATY-RATTRDVEVAGQRLSADQMVMVWFG 332 Query: 409 SLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVL 468 + R+ F PE ++ R G N H+ FG G+ CLG LA E + L H+L Sbjct: 333 AANRDARQFAEPELFDMTR-------GPN-PHLGFGRGIHFCLGGPLARMEGRVALDHLL 384 Query: 469 K 469 Sbjct: 385 D 385 >3AWQ-A nrPDB Length = 415 Score = 36.6 bits (83), Expect = 0.027, Method: Compositional matrix adjust. Identities = 32/127 (25%), Positives = 52/127 (40%), Gaps = 5/127 (3%) Query: 369 LKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRW 428 ++E R YP + AS D + P G V + LY + A + P+ + P+R+ Sbjct: 278 VQEVRRFYPFFPAVVARASQDFEWEGMAFPEGRQVVLDLYGSNHDAATWADPQEFRPERF 337 Query: 429 LDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQE--DIKMVYS 486 NF +P G G LG R ++L + V HL V + + D + Sbjct: 338 RAWDEDSFNF--IPQG-GGDHYLGHRCPGEWIVLAIMKVAAHLLVNAMRYDVPDQDLSID 394 Query: 487 FILRPSM 493 F P++ Sbjct: 395 FARLPAL 401 >6F88-A nrPDB Length = 400 Score = 36.6 bits (83), Expect = 0.028, Method: Compositional matrix adjust. Identities = 54/250 (21%), Positives = 101/250 (40%), Gaps = 46/250 (18%) Query: 228 EVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYT 287 E + ++ ++ M R L R P E A+ +++ ++ + Sbjct: 146 EKLHETDERVRAMLRGLVRMHDPAAVAESQRAYGETLGLITEVVERESRDTS-------D 198 Query: 288 SIVAELL--LNAELSPDAIKANS---MELTAGSVDTTVFPLLMTLFELARNPNVQQALRQ 342 +++ E+L L AE D I+A+ + L G +TT + + T+ L +P+ +RQ Sbjct: 199 TLLGEILRTLKAE-HMDTIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQ 257 Query: 343 ESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTL 402 + LL AA++E +R P + R+ D+ L + + AGT+ Sbjct: 258 DP------------------SLLPAAIEEGMRWCPSNFGVLRMVERDVRLDDQALSAGTV 299 Query: 403 VRVFLYSLGRNPALFPRPERYNPQR----WLDIRGSGRNFYHVPFGFGMRQCLGRRLAEA 458 V + + + +P PE Y+ R ++ G G +F C+G LA Sbjct: 300 VCLAGIAGNYDETAYPSPEVYDIDRKPLPAANVFGGGAHF-----------CVGAPLARM 348 Query: 459 EMLLLLHHVL 468 E + L +L Sbjct: 349 EARVGLQALL 358 >1Q5D-A nrPDB Length = 419 Score = 36.2 bits (82), Expect = 0.030, Method: Compositional matrix adjust. Identities = 45/188 (23%), Positives = 74/188 (39%), Gaps = 32/188 (17%) Query: 290 VAELLLNAE-----LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQES 344 V +LL AE LS + A + A DTT++ + + L R+P + ++ E Sbjct: 225 VLTMLLQAEADGSRLSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAEP 284 Query: 345 LAAAASISEHPQKATTELPLLRAALKETLRLYPV-GLFLERVASSDLVLQNYHIPAGTLV 403 L+R AL E LR + + R A DL I G +V Sbjct: 285 ------------------GLMRNALDEVLRFDNILRIGTVRFARQDLEYCGASIKKGEMV 326 Query: 404 RVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLL 463 + + S R+ +F RP+ ++ +R D S + +G G C G LA E + Sbjct: 327 FLLIPSALRDGTVFSRPDVFDVRR--DTSAS------LAYGRGPHVCPGVSLARLEAEIA 378 Query: 464 LHHVLKHL 471 + + + Sbjct: 379 VGTIFRRF 386 >5HIW-A nrPDB Length = 398 Score = 36.2 bits (82), Expect = 0.037, Method: Compositional matrix adjust. Identities = 44/172 (25%), Positives = 74/172 (43%), Gaps = 30/172 (17%) Query: 288 SIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAA 347 +IVAE L E A + + L GS +TT + L L L +P+ LRQ+ Sbjct: 206 AIVAEGLGGVE----ACEGVVLTLILGSYETTSWMLANLLVALLAHPDAMNQLRQQPSLL 261 Query: 348 AASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFL 407 +I E + ++ ++R F+ER A+ + + AGT++ + L Sbjct: 262 PQAIEESTRWCSSAAGIVR--------------FVEREAT----IGGETLAAGTILYLSL 303 Query: 408 YSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAE 459 + + ++PRPE ++ R R + FG G+ C+G LA E Sbjct: 304 IARHYDEEIYPRPETFDIHR--------RPVGMLNFGGGLHYCVGAPLARME 347 >5ZR1-C nrPDB Length = 616 Score = 35.0 bits (79), Expect = 0.082, Method: Compositional matrix adjust. Identities = 30/98 (30%), Positives = 49/98 (50%), Gaps = 9/98 (9%) Query: 244 LSRWTSPKVWKE--HFEAWDCIFQ---YGDNCIQKIYQELAFSRPQQYTSIVAELLLNAE 298 L RW++ K +K+ HFE D IFQ DN + Q + S Y S + + LL+ E Sbjct: 440 LDRWSACKEYKDRLHFEPIDTIFQELFTLDNRSGLLTQSIFPS----YKSNIEDNLLSWE 495 Query: 299 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNV 336 ++ + + +G +D + P+L LF+L R N+ Sbjct: 496 QVLPSLDKENYDTLSGDLDKIMAPVLGQLFKLYREANM 533 >6DCD-A nrPDB Length = 424 Score = 34.7 bits (78), Expect = 0.095, Method: Compositional matrix adjust. Identities = 39/170 (22%), Positives = 67/170 (39%), Gaps = 26/170 (15%) Query: 302 DAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTE 361 D +++ + AG +TT L + L P++Q+ LR+ Sbjct: 241 DVVRSATFLFAAGQ-ETTAKLLTAAMRVLGDRPDIQRRLRENR----------------- 282 Query: 362 LPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPE 421 L+ ++E+LR+ R+A + I AGT+V V + R+P F P Sbjct: 283 -SLIPNFIEESLRMDSPVKSDSRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPH 341 Query: 422 RYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471 + R ++R H+ F G+ C G LA E + L +L + Sbjct: 342 EFRLDRP-NVR------EHMAFARGVHSCPGGPLARVEGRVSLERILDRM 384 >1EHE-A nrPDB Length = 403 Score = 34.7 bits (78), Expect = 0.11, Method: Compositional matrix adjust. Identities = 30/117 (25%), Positives = 51/117 (43%), Gaps = 12/117 (10%) Query: 349 ASISEHPQKAT--TELPLLRAALKETLRLY--PVGLFLERVASSDLVLQNYHIPAGTLVR 404 A++++HP + P L E L Y L ++R A D+++ + + A + Sbjct: 253 ATLAQHPDQLAQLKANPSLAPQFVEELCRYHTASALAIKRTAKEDVMIGDKLVRANEGII 312 Query: 405 VFLYSLGRNPALFPRPERYNPQR-WLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEM 460 S R+ +F P+ +N R W G FGFG +C+ LA+AE+ Sbjct: 313 ASNQSANRDEEVFENPDEFNMNRKWPPQDPLG-------FGFGDHRCIAEHLAKAEL 362 >5EX8-A nrPDB Length = 424 Score = 34.7 bits (78), Expect = 0.11, Method: Compositional matrix adjust. Identities = 23/74 (31%), Positives = 34/74 (45%), Gaps = 9/74 (12%) Query: 384 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF 443 RVA+ D+ + N + AG V L + R P + + DI + H+ F Sbjct: 318 RVATQDVRIGNQLVKAGDTVTCSLLAANR-------PNYPSAEDEFDI--TREKAEHLAF 368 Query: 444 GFGMRQCLGRRLAE 457 G G+ CLGR +AE Sbjct: 369 GHGIHHCLGRAMAE 382 >6A7J-A nrPDB Length = 411 Score = 33.9 bits (76), Expect = 0.17, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 43/100 (43%), Gaps = 8/100 (8%) Query: 366 RAALKETLRL-YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYN 424 ++ETLR P L R A+ D+ + + +P G + V +LGR+ E+Y Sbjct: 274 EGVIEETLRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDE------EQYG 327 Query: 425 PQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLL 464 P D + H+ FG G C G L+ E + L Sbjct: 328 PTAG-DFDATRTPNRHIAFGHGPHVCPGAALSRLEAGIAL 366 >5OMS-A nrPDB Length = 409 Score = 33.5 bits (75), Expect = 0.23, Method: Compositional matrix adjust. Identities = 31/142 (21%), Positives = 58/142 (40%), Gaps = 10/142 (7%) Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLR-LYPVGLFLERVASSDLVLQNYHIPAGTL 402 +L S E ++ + L+ A+ E LR P+ R+++ + + +PAGT Sbjct: 259 TLVGLFSRPEQLEEVVDDPTLIPRAIAEGLRWTSPIWSATARISTKPVTIAGVDLPAGTP 318 Query: 403 VRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLL 462 V + S + + P +Y+ R H+ FG G C G A M + Sbjct: 319 VMLSYGSANHDTGKYEAPSQYDLHR--------PPLPHLAFGAGNHACAGIYFANHVMRI 370 Query: 463 LLHHVLKHL-QVETLTQEDIKM 483 L + + + +E T+E ++ Sbjct: 371 ALEELFEAIPNLERDTREGVEF 392 >6FSH-A nrPDB Length = 398 Score = 33.1 bits (74), Expect = 0.29, Method: Compositional matrix adjust. Identities = 41/173 (23%), Positives = 68/173 (39%), Gaps = 27/173 (15%) Query: 288 SIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAA 347 SIVAE ++ + ++ ++L D + + + L R+P ALR + +A Sbjct: 212 SIVAEH--GDTITDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQSA 269 Query: 348 AASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFL 407 ++ E L+R T+ P R A D+++ + I G V L Sbjct: 270 DRAVDE----------LIRYL---TVPYAPT----PRTAVEDVMVADQVIKEGETVLCSL 312 Query: 408 YSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEM 460 R+ AL P +R + R HV FG G+ CLG L ++ Sbjct: 313 PMANRDRALLPDADRLDVTRT--------PVPHVAFGHGIHHCLGAALTRLQL 357 >6M7L-A nrPDB Length = 404 Score = 32.7 bits (73), Expect = 0.37, Method: Compositional matrix adjust. Identities = 44/144 (30%), Positives = 64/144 (44%), Gaps = 22/144 (15%) Query: 324 LMTLFELARNPNVQQALRQESLAAAASIS--EHPQKAT--TELPLL-RAALKETLRLYPV 378 L L + N +V+Q ES AA ++ EHP++ E P L A++E +R V Sbjct: 234 LAGLCAVVMNSSVEQT---ESCLAAGTLLLLEHPEQFALLRERPELGEQAVEEIVRYLSV 290 Query: 379 GLFLE-RVASSDLVLQNYHIPAGTLVRVFLYSLGR-NPALFPRPERYNPQRWLDIRGSGR 436 L+ R A+ D+ + I G V L + R +PAL DI + + Sbjct: 291 FEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAANRADPAL----------DGFDI--TRK 338 Query: 437 NFYHVPFGFGMRQCLGRRLAEAEM 460 HV FG G+ CLG LA E+ Sbjct: 339 ESRHVAFGHGIHHCLGAPLARMEL 362 >4TX3-A nrPDB Length = 404 Score = 32.7 bits (73), Expect = 0.42, Method: Compositional matrix adjust. Identities = 41/173 (23%), Positives = 68/173 (39%), Gaps = 27/173 (15%) Query: 288 SIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAA 347 SIVAE ++ + ++ ++L D + + + L R+P ALR + +A Sbjct: 218 SIVAEH--GDTITDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQSA 275 Query: 348 AASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFL 407 ++ E L+R T+ P R A D+++ + I G V L Sbjct: 276 DRAVDE----------LIRYL---TVPYAPT----PRTAVEDVMVADQVIKEGETVLCSL 318 Query: 408 YSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEM 460 R+ AL P +R + R HV FG G+ CLG L ++ Sbjct: 319 PMANRDRALLPDADRLDVTRT--------PVPHVAFGHGIHHCLGAALTRLQL 363 >4JBT-A nrPDB Length = 410 Score = 32.3 bits (72), Expect = 0.46, Method: Compositional matrix adjust. Identities = 37/129 (28%), Positives = 57/129 (44%), Gaps = 20/129 (15%) Query: 345 LAAAASISEHPQKATTELPLLR-------AALKETLRLY-PVGLFLERVASSDLVLQNYH 396 L A ++ HP+ +L L+R A++ETLR PV L R A+ D+ L + Sbjct: 254 LTAVRALLSHPE----QLRLVRDGEIGWETAIEETLRWDGPVIHLLMRFATEDIDLGDAV 309 Query: 397 IPAGTLVRVFLYSLGRNPALF-PRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRL 455 IP G V + ++GR+ + + ++ R R H+ FG G C G L Sbjct: 310 IPRGEGVVMSYRAIGRDITVHGADADDFDITRATAAR-------HISFGHGPHICPGAAL 362 Query: 456 AEAEMLLLL 464 A E + L Sbjct: 363 ARLEAAIAL 371 >2UUQ-A nrPDB Length = 414 Score = 32.3 bits (72), Expect = 0.47, Method: Compositional matrix adjust. Identities = 34/131 (25%), Positives = 51/131 (38%), Gaps = 10/131 (7%) Query: 368 ALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQR 427 A++E LRL L R + D+ + + IPAG V + S R+ +Y P Sbjct: 286 AVEELLRLTSPVQGLARTTTRDVTIGDTTIPAGRRVLLLYGSANRD------ERQYGPDA 339 Query: 428 W-LDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL-QVETLTQEDIKMVY 485 LD+ RN + F G CLG A + + L +L E + Sbjct: 340 AELDVTRCPRNI--LTFSHGAHHCLGAAAARMQCRVALTELLARCPDFEVAESRIVWSGG 397 Query: 486 SFILRPSMFPL 496 S++ RP P Sbjct: 398 SYVRRPLSVPF 408 >2X9P-A nrPDB Length = 404 Score = 32.3 bits (72), Expect = 0.49, Method: Compositional matrix adjust. Identities = 48/173 (27%), Positives = 70/173 (40%), Gaps = 29/173 (16%) Query: 297 AELSPDAI-KANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHP 355 AE PD I + N ELT V LL + +V + + AA HP Sbjct: 211 AEPGPDIISRLNDGELTEDRVAHLAMGLLFAGLD-----SVASIMDNGVVLLAA----HP 261 Query: 356 QK---ATTELPLLRAALKETLRLYPVG--LFLERVASSDLVLQNYHIPAGTLVRVFLYSL 410 + A + ++ A++E LR G + R AS D+ I AG LV L+ L Sbjct: 262 DQRAAALADPDVMARAVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLV---LFDL 318 Query: 411 GR---NPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEM 460 G + F PE ++ R + H+ FG G+ C+G LA E+ Sbjct: 319 GLPNFDERAFTGPEEFDAARTPN--------PHLTFGHGIWHCIGAPLARLEL 363 >3DBM-A nrPDB Length = 473 Score = 32.0 bits (71), Expect = 0.66, Method: Compositional matrix adjust. Identities = 30/124 (24%), Positives = 57/124 (45%), Gaps = 8/124 (6%) Query: 312 TAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEH--PQKATTELPLLRAAL 369 T G V +FP + LA N+ L +E A S + +A ++PL ++ + Sbjct: 277 TFGGVKI-LFPNTLKWIGLAGE-NLHTQLAEEIRGAIKSYGDGNVTLEAIEQMPLTKSVV 334 Query: 370 KETLRLYPVGLFLERVASSDLVLQN----YHIPAGTLVRVFLYSLGRNPALFPRPERYNP 425 E+LR+ P A S+ +++ + + G ++ + ++P +F RPE Y P Sbjct: 335 YESLRIEPPVPPQYGKAKSNFTIESHDATFEVKKGEMLFGYQPFATKDPKVFDRPEEYVP 394 Query: 426 QRWL 429 R++ Sbjct: 395 DRFV 398 >5XNT-A nrPDB Length = 411 Score = 31.6 bits (70), Expect = 0.92, Method: Compositional matrix adjust. Identities = 55/249 (22%), Positives = 94/249 (37%), Gaps = 39/249 (15%) Query: 229 VMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTS 288 ++FK V ++F+P + K+ A +QY +Y + R Sbjct: 163 LLFKKWVDILFLPFDKEKQEEVNELKQV--AAKEYYQY-------LYPIVVQKRLNPADD 213 Query: 289 IVAELL---LNAEL-SPDAIKANSMELTAGSVDTTVFPLLMTLFEL-ARNPNVQQALRQE 343 I+++LL ++ E+ + D + +M + V+TT L + + L + V Q L + Sbjct: 214 IISDLLKAEVDGEMFTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHEN 273 Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLV 403 L L+ A++E LR + L+R D L + G V Sbjct: 274 ------------------LDLVPQAVEEMLRYRFNLIKLDRTVKEDNDLLGVELKEGENV 315 Query: 404 RVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLL 463 V++ + + +F N R N H+ FG G CLG LA E + Sbjct: 316 VVWMSAANLDEEMFEDAFTLNIHR-------PNNKKHLTFGNGPHFCLGAPLARLEAKIA 368 Query: 464 LHHVLKHLQ 472 L LK + Sbjct: 369 LTTFLKKFK 377 >2YJN-B nrPDB Length = 381 Score = 31.2 bits (69), Expect = 0.98, Method: Compositional matrix adjust. Identities = 38/141 (26%), Positives = 61/141 (43%), Gaps = 15/141 (10%) Query: 291 AELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLF---ELARNPNVQQALRQESLAA 347 A + L+A+LSP + + A D P L LF E+ N V L + Sbjct: 188 ARVSLDAQLSPQQLAVTEAAVAALPAD----PALRALFAGAEMTANTVVDAVLAVSAEPG 243 Query: 348 -AASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVF 406 A I++ P A + + E LRL+P R A++++ L + I G V V Sbjct: 244 LAERIADDPAAA-------QRTVAEVLRLHPALHLERRTATAEVRLGEHVIGEGEEVVVV 296 Query: 407 LYSLGRNPALFPRPERYNPQR 427 + + R+P +F P+R + R Sbjct: 297 VAAANRDPEVFAEPDRLDVDR 317 >1XDN-A nrPDB Length = 277 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 22/96 (22%), Positives = 40/96 (41%), Gaps = 4/96 (4%) Query: 96 DVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPN--- 152 D+ ++ SLH ++ + WVA + G G++L+N + R ++ PN Sbjct: 15 DLPSESRIQSLHKSGLAAQEWVACEKVHGTNFGIYLINQGDHEVVRFAKRSGIMDPNENF 74 Query: 153 -AVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLD 187 + A R + LK+K + G L L+ Sbjct: 75 FGYHILIDEFTAQIRILNDLLKQKYGLSRVGRLVLN 110 >5OQL-R nrPDB Length = 313 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 21/79 (26%), Positives = 37/79 (46%), Gaps = 7/79 (8%) Query: 125 HKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQ-NAR-- 181 H+ G L+N R N + + + P A + +PMVD + D +Q + +++ NAR Sbjct: 187 HRSGRDLINMATRRTNVIPIVEDARKPMAYRMLVPMVDVIFADVAQPDQARIVGINARLF 246 Query: 182 ----GSLTLDVQPSIFHYT 196 G L + ++ S T Sbjct: 247 LKQGGGLLISIKASCIDST 265 >3BUJ-A nrPDB Length = 397 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 27/96 (28%), Positives = 42/96 (43%), Gaps = 8/96 (8%) Query: 364 LLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERY 423 LL A++E LR P R D+ L+ + +V V + R+P + RP+ + Sbjct: 265 LLAQAVEECLRYDPSVQSNTRQLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDF 324 Query: 424 NPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAE 459 + +R + FG GMR CLG LA + Sbjct: 325 DIER--------DPVPSMSFGAGMRYCLGSYLARTQ 352 >4Z5Q-A nrPDB Length = 423 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 55/254 (21%), Positives = 92/254 (36%), Gaps = 31/254 (12%) Query: 213 GHSPSSASLNFLHALEVMFKSTVQLMFMPRS----LSRWTSPKVWKEHFEAWDCIFQYGD 268 G +P A L +AL + +L+ +P L W + +C+ + D Sbjct: 157 GGAP--AELVGSYALAIPVTVICELLGVPEDDRTRLRGWCDAALSTGELTDEECVQSFMD 214 Query: 269 NCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLF 328 +QK +++L R + + L+ A + D + EL + + T Sbjct: 215 --LQKYFEDLVKERRAEPRDDLTSALIEARDAHDRLA--EPELIGLCISILIGGFETTAS 270 Query: 329 ELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGL--FLERVA 386 E++ +V Q R+ A P AA++E LR P R A Sbjct: 271 EISSFVHVLQQRRELWTRLCADPEAIP-----------AAVEELLRFVPFAANGISPRYA 319 Query: 387 SSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFG 446 D+ + + G V V ++ R+ +F N + R R H+ FG G Sbjct: 320 LEDMTVGGVLVREGEPVIVDTSAVNRDGLVFD-----NADEVVIDRADNR---HMVFGHG 371 Query: 447 MRQCLGRRLAEAEM 460 CLG LA E+ Sbjct: 372 AHHCLGAHLARVEL 385 >2RCM-A nrPDB Length = 495 Score = 30.8 bits (68), Expect = 1.4, Method: Compositional matrix adjust. Identities = 25/109 (22%), Positives = 49/109 (44%), Gaps = 14/109 (12%) Query: 358 ATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQN----YHIPAGTLVRVFLYSLGRN 413 A ++ L ++ + E LR P A DLV+++ + + AG ++ + R+ Sbjct: 340 AIEKMELTKSVVYECLRFEPPVTAQYGRAKKDLVIESHDAAFKVKAGEMLYGYQPLATRD 399 Query: 414 PALFPRPERYNPQRWLDIRGSGRNFYHVPFG---------FGMRQCLGR 453 P +F R + + P+R++ G + HV + G +QC G+ Sbjct: 400 PKIFDRADEFVPERFVGEEGE-KLLRHVLWSNGPETETPTVGNKQCAGK 447 >6A7I-A nrPDB Length = 411 Score = 30.8 bits (68), Expect = 1.4, Method: Compositional matrix adjust. Identities = 26/99 (26%), Positives = 43/99 (43%), Gaps = 8/99 (8%) Query: 367 AALKETLRL-YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNP 425 ++ETLR P L R A+ D+ + + +P G + + +LGR+ E+Y P Sbjct: 275 GVIEETLRWNTPTSHVLIRFATEDIEVGDKILPKGEGLIISFGALGRDE------EQYGP 328 Query: 426 QRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLL 464 + + H+ FG G C G L+ E + L Sbjct: 329 TAG-EFDATRTPNRHIAFGHGPHVCPGAALSRLEAGIAL 366 >1V10-A nrPDB Length = 521 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 24/71 (33%), Positives = 31/71 (43%), Gaps = 5/71 (7%) Query: 294 LLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISE 353 +LNA L PD A S G TT+ PL+ + NV L ++ A SI Sbjct: 30 ILNANLDPDGTGARSAVTAEG---TTIAPLITGNIDDRFQINVIDQLTDANMRRATSIHW 86 Query: 354 HP--QKATTEL 362 H Q TTE+ Sbjct: 87 HGFFQAGTTEM 97 >5KYO-A nrPDB Length = 430 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 47/189 (24%), Positives = 75/189 (39%), Gaps = 28/189 (14%) Query: 309 MELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAA 368 +++ G +DT V L T LA++ ALR+ ++AA S L+ A Sbjct: 265 IQVLVGGLDTVVNMLGFTFSHLAKD----HALRR-AIAADPS-------------LIDDA 306 Query: 369 LKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRW 428 L E R +PV + R D + + AG +V + + A P Sbjct: 307 LLEFFRRFPV-VSSAREVLRDQEFEGVLLKAGDMVMAPTVVVAMDDARNEDP-------- 357 Query: 429 LDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFI 488 L+ R + H FG G C G LA EM ++L + E ++D + YS Sbjct: 358 LEFRLGRKARQHSTFGKGSHTCPGAHLARMEMKVVLREWFARIP-EFRIEDDAPLRYSNG 416 Query: 489 LRPSMFPLL 497 + S+ P + Sbjct: 417 IVGSVKPFV 425 >5YS9-A nrPDB Length = 708 Score = 30.0 bits (66), Expect = 2.6, Method: Compositional matrix adjust. Identities = 26/75 (34%), Positives = 40/75 (53%), Gaps = 11/75 (14%) Query: 304 IKANSMELTAGSVDTTVFPLLMTLFELARNP--NV-------QQALRQESLAAAASISEH 354 IK + L G + T+ LMT EL R+P NV ++ LR+ ++A A++S H Sbjct: 38 IKDMTEFLHGGEENVTMIERLMT--ELERDPVLNVSGDYDMPKEQLRETAVARIAALSGH 95 Query: 355 PQKATTELPLLRAAL 369 +K T + LLR+ L Sbjct: 96 WKKDTEKEALLRSQL 110 >3OO3-A nrPDB Length = 384 Score = 29.6 bits (65), Expect = 3.0, Method: Compositional matrix adjust. Identities = 27/106 (25%), Positives = 47/106 (44%), Gaps = 14/106 (13%) Query: 364 LLRAALKETLRLYP-VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPER 422 L+ +A +E LR V RVA +D+ + I AG ++ + + R P +R Sbjct: 258 LIDSATEEVLRHASIVEAPAPRVALADVRMAGRDIHAGDVLTCSMLATNRAPG-----DR 312 Query: 423 YNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVL 468 ++ R H+ FG G+ C+G LA ++ + L V+ Sbjct: 313 FDITR--------EKATHMAFGHGIHHCIGAPLARLQLRVALPAVV 350 >2QBO-A nrPDB Length = 421 Score = 29.3 bits (64), Expect = 4.1, Method: Compositional matrix adjust. Identities = 45/187 (24%), Positives = 73/187 (39%), Gaps = 32/187 (17%) Query: 288 SIVAELLLNAE-LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLA 346 SIVA +N ++ D K L +DT V L ++ LA++P +Q L Sbjct: 222 SIVANGQVNGRPITSDEAKRMCGLLLVVGLDTVVNFLSFSMEFLAKSPEHRQEL------ 275 Query: 347 AAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGT--LVR 404 E P++ + AA +E LR + + + R+ +SD + G L+ Sbjct: 276 -----IERPER-------IPAACEELLRRFSL-VADGRILTSDYEFHGVQLKKGDQILLP 322 Query: 405 VFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLL 464 L L P + + S + H FG G CLG+ LA E+++ L Sbjct: 323 QMLSGLDERENACP----------MHVDFSRQKVSHTTFGHGSHLCLGQHLARREIIVTL 372 Query: 465 HHVLKHL 471 L + Sbjct: 373 KEWLTRI 379 >4FB2-A nrPDB Length = 398 Score = 28.1 bits (61), Expect = 8.2, Method: Compositional matrix adjust. Identities = 22/108 (20%), Positives = 46/108 (42%), Gaps = 9/108 (8%) Query: 364 LLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERY 423 L+ A+ E LR Y + + R+ + ++ + + + G ++ R+ + F P+ Sbjct: 264 LIPNAVDELLRFYGPAM-VGRLVTQEVTVGDITMKPGQTAMLWFPIASRDRSAFDSPDNI 322 Query: 424 NPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471 +R + H+ G G+ +CLG L E + + LK + Sbjct: 323 VIERTPN--------RHLSLGHGIHRCLGAHLIRVEARVAITEFLKRI 362 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6M7X-A nrPDB 609 e-175 4ZGX-A nrPDB 578 e-165 3N9Z-A nrPDB 505 e-143 3MZS-A nrPDB 498 e-141 3K9V-A nrPDB 414 e-116 3E6I-A nrPDB 327 6e-90 3DL9-A nrPDB 324 8e-89 3MDV-A nrPDB 303 9e-83 5W0C-A nrPDB 282 2e-76 4GQS-A nrPDB 278 4e-75 2NNH-A nrPDB 274 6e-74 1N6B-A nrPDB 273 2e-73 6C94-A nrPDB 270 9e-73 6HQW-A nrPDB 265 3e-71 5E0E-A nrPDB 258 3e-69 4H1N-A nrPDB 257 9e-69 5E58-A nrPDB 256 1e-68 3IBD-A nrPDB 254 7e-68 4WMZ-A nrPDB 253 1e-67 5JLC-A nrPDB 253 1e-67 6B82-A nrPDB 252 2e-67 2PG7-A nrPDB 251 6e-67 5VEU-A nrPDB 249 2e-66 6DA2-A nrPDB 242 2e-64 4R1Z-A nrPDB 240 1e-63 4R20-A nrPDB 240 1e-63 5UYS-A nrPDB 235 3e-62 3TBG-A nrPDB 225 3e-59 3RWL-A nrPDB 224 8e-59 5VBU-A nrPDB 218 5e-57 3QZ1-A nrPDB 216 2e-56 6DWN-A nrPDB 216 2e-56 6AYB-A nrPDB 213 2e-55 5YLW-A nrPDB 208 4e-54 6HQG-A nrPDB 207 8e-54 2HI4-A nrPDB 207 1e-53 2VE3-A nrPDB 206 2e-53 5FSA-A nrPDB 205 4e-53 6IQ5-A nrPDB 202 3e-52 5H1Z-A nrPDB 201 5e-52 5OFQ-A nrPDB 200 1e-51 1UED-A nrPDB 199 2e-51 3JUS-A nrPDB 195 5e-50 4RM4-A nrPDB 191 5e-49 3EJB-B nrPDB 189 2e-48 3L4D-A nrPDB 189 2e-48 4KPA-A nrPDB 188 5e-48 3EL3-A nrPDB 188 6e-48 5FYF-A nrPDB 187 1e-47 2WX2-A nrPDB 187 1e-47 5VWS-A nrPDB 187 1e-47 5LIE-A nrPDB 185 4e-47 6CR2-A nrPDB 185 5e-47 5L94-A nrPDB 184 6e-47 2W0A-A nrPDB 184 1e-46 6HQD-A nrPDB 183 1e-46 2XKR-A nrPDB 183 2e-46 3S79-A nrPDB 181 6e-46 4TRI-A nrPDB 181 8e-46 1CPT-A nrPDB 178 6e-45 6CVC-A nrPDB 178 6e-45 2X2N-A nrPDB 178 7e-45 2ZBZ-A nrPDB 178 8e-45 3MGX-A nrPDB 177 1e-44 4PWV-A nrPDB 174 7e-44 2WIO-A nrPDB 174 9e-44 5FOI-A nrPDB 173 1e-43 5CJE-A nrPDB 173 2e-43 3A50-A nrPDB 172 3e-43 6B11-A nrPDB 172 4e-43 6GMF-A nrPDB 171 6e-43 5Y1I-A nrPDB 171 7e-43 2VZM-A nrPDB 171 9e-43 4Z5P-A nrPDB 169 2e-42 2Y5N-A nrPDB 169 2e-42 6GK6-A nrPDB 168 4e-42 4GGV-A nrPDB 168 4e-42 4YZR-A nrPDB 168 5e-42 3ABB-A nrPDB 168 8e-42 5XJN-A nrPDB 167 1e-41 4WPZ-A nrPDB 166 2e-41 5GWE-A nrPDB 166 2e-41 3R9C-A nrPDB 166 3e-41 2Z36-A nrPDB 164 7e-41 4UBS-A nrPDB 164 1e-40 3TYW-A nrPDB 163 2e-40 4OQS-A nrPDB 162 3e-40 1Z8P-A nrPDB 162 4e-40 2FR7-A nrPDB 161 5e-40 4OQR-A nrPDB 161 7e-40 3TKT-A nrPDB 161 8e-40 3P3Z-A nrPDB 161 8e-40 2RFC-A nrPDB 160 2e-39 3ABA-A nrPDB 159 2e-39 5IT1-A nrPDB 159 2e-39 1LG9-A nrPDB 159 3e-39 4DO1-A nrPDB 156 3e-38 3NC3-A nrPDB 155 4e-38 3A1L-A nrPDB 154 9e-38 1F4U-A nrPDB 152 4e-37 5DE9-A nrPDB 152 4e-37 1UE8-A nrPDB 151 6e-37 5HDI-A nrPDB 147 7e-36 6F0B-A nrPDB 147 1e-35 5YSW-A nrPDB 147 1e-35 6GII-A nrPDB 146 2e-35 3SN5-A nrPDB 146 2e-35 2WIY-A nrPDB 141 6e-34 3OFT-A nrPDB 137 1e-32 6FYJ-A nrPDB 134 8e-32 5D3U-A nrPDB 132 2e-31 5YHJ-A nrPDB 124 1e-28 1WIY-A nrPDB 121 5e-28 5HH3-A nrPDB 118 6e-27 2IAG-A nrPDB 114 1e-25 2ZQJ-A nrPDB 111 1e-24 5M0P-A nrPDB 108 5e-24 Sequences not found previously or not previously below threshold: 2WM5-A nrPDB 180 1e-45 5DQN-A nrPDB 174 7e-44 5XW2-A nrPDB 165 4e-41 3WVS-A nrPDB 164 6e-41 4YT3-A nrPDB 163 1e-40 5EX6-C nrPDB 159 3e-39 5XNT-A nrPDB 159 4e-39 6FSH-A nrPDB 156 2e-38 5Z9I-A nrPDB 154 6e-38 1EHE-A nrPDB 153 2e-37 4TX3-A nrPDB 152 4e-37 3IVY-A nrPDB 152 4e-37 5NWS-A nrPDB 151 6e-37 1ODO-A nrPDB 151 6e-37 4XE3-A nrPDB 147 1e-35 4JBT-A nrPDB 145 5e-35 4MM0-A nrPDB 144 7e-35 6A7J-A nrPDB 144 1e-34 6M7L-A nrPDB 143 1e-34 4Z5Q-A nrPDB 143 1e-34 6A7I-A nrPDB 142 2e-34 5LIV-A nrPDB 141 6e-34 6F88-A nrPDB 141 7e-34 6DCD-A nrPDB 139 2e-33 2X9P-A nrPDB 137 7e-33 2UUQ-A nrPDB 137 9e-33 1Q5D-A nrPDB 135 6e-32 6BLD-A nrPDB 134 8e-32 5L1U-A nrPDB 132 4e-31 6G5O-A nrPDB 131 5e-31 2NZA-A nrPDB 129 3e-30 1GWI-A nrPDB 129 4e-30 5HIW-A nrPDB 128 5e-30 2IJ7-A nrPDB 128 6e-30 3OO3-A nrPDB 127 2e-29 3BUJ-A nrPDB 126 2e-29 3WEC-A nrPDB 122 2e-28 6G71-A nrPDB 119 4e-27 4FB2-A nrPDB 112 2e-25 3NV6-A nrPDB 111 9e-25 2QBO-A nrPDB 109 2e-24 5EX8-A nrPDB 107 1e-23 5KYO-A nrPDB 105 5e-23 5OMS-A nrPDB 103 2e-22 2RCM-A nrPDB 97 2e-20 3AWQ-A nrPDB 97 2e-20 4C9K-A nrPDB 96 4e-20 3B98-A nrPDB 86 3e-17 3DBM-A nrPDB 84 1e-16 2YJN-B nrPDB 66 3e-11 4YXC-B nrPDB 34 0.23 4YXB-D nrPDB 31 0.98 6F73-A nrPDB 31 1.0 3GFZ-A nrPDB 30 2.5 3RP9-A nrPDB 29 3.8 2OG9-A nrPDB 29 6.7 2VUU-A nrPDB 28 7.9 1ASZ-A nrPDB 28 9.4 3V7O-A nrPDB 28 9.8 >6M7X-A nrPDB Length = 484 Score = 609 bits (1570), Expect = e-175, Method: Composition-based stats. Identities = 473/480 (98%), Positives = 476/480 (99%) Query: 24 LGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDL 83 + + + VPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDL Sbjct: 1 MAKKTSSVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDL 60 Query: 84 GGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR 143 GGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR Sbjct: 61 GGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR 120 Query: 144 LNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 203 LNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA Sbjct: 121 LNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 180 Query: 204 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCI 263 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCI Sbjct: 181 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCI 240 Query: 264 FQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPL 323 FQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPL Sbjct: 241 FQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPL 300 Query: 324 LMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 383 LMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE Sbjct: 301 LMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 360 Query: 384 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF 443 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF Sbjct: 361 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF 420 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN 503 GFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN Sbjct: 421 GFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN 480 >4ZGX-A nrPDB Length = 489 Score = 578 bits (1490), Expect = e-165, Method: Composition-based stats. Identities = 446/480 (92%), Positives = 457/480 (95%) Query: 24 LGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDL 83 + T+AAR PRTVLPFEAMP+ PGNRWLRLLQIWREQGYE LHLE+HQTFQELGPIFRY+L Sbjct: 1 MATKAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNL 60 Query: 84 GGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR 143 GG MVCVMLPEDVEKLQQVDSLHP RM LEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR Sbjct: 61 GGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLR 120 Query: 144 LNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 203 LNP+VLSP AVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA Sbjct: 121 LNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 180 Query: 204 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCI 263 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRW SPKVWKEHFEAWDCI Sbjct: 181 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCI 240 Query: 264 FQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPL 323 FQYGDNCIQKIYQELAF+RPQ YT IVAELLL AELS +AIKANSMELTAGSVDTT FPL Sbjct: 241 FQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPL 300 Query: 324 LMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 383 LMTLFELARNP+VQQ LRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE Sbjct: 301 LMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 360 Query: 384 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF 443 RV SSDLVLQNYHIPAGTLV+VFLYSLGRN ALFPRPERYNPQRWLDIRGSGRNF+HVPF Sbjct: 361 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF 420 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN 503 GFGMRQCLGRRLAEAEMLLLLHHVLKH VETLTQEDIKMVYSFILRP PLLTFRAIN Sbjct: 421 GFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN 480 >3N9Z-A nrPDB Length = 487 Score = 505 bits (1301), Expect = e-143, Method: Composition-based stats. Identities = 186/478 (38%), Positives = 269/478 (56%), Gaps = 5/478 (1%) Query: 28 AARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAG 87 + R PR PF +P N WL L WRE G +HL Q FQ+ GPI+R LG Sbjct: 1 STRSPR---PFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVE 57 Query: 88 MVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPE 147 V V+ PEDV L + + +P R + PWVAY Q+ GV L W+ +R+ LN E Sbjct: 58 SVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQE 117 Query: 148 VLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGE 207 V++P A + FLP++DAV+RDF L +++ + G+ + D+ +F + E+ +FGE Sbjct: 118 VMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGE 177 Query: 208 RLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYG 267 R G++ + + F+ A+ MF ++V ++ +P L R K WK+H AWD IF Sbjct: 178 RQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKA 237 Query: 268 DNCIQKIYQELA--FSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLM 325 D Q Y EL S Y I+ LL ++++S + IKAN E+ AG VDTT L Sbjct: 238 DIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQW 297 Query: 326 TLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERV 385 L+E+ARN VQ LR E LAA +PLL+A++KETLRL+P+ + L+R Sbjct: 298 HLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRY 357 Query: 386 ASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGF 445 +DLVL++Y IPA TLV+V +Y+LGR P F PE ++P RWL + F ++ FG+ Sbjct: 358 LVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGW 417 Query: 446 GMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN 503 G+RQCLGRR+AE EM + L ++L++ +VE D+ ++ IL P TF N Sbjct: 418 GVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFN 475 >3MZS-A nrPDB Length = 486 Score = 498 bits (1282), Expect = e-141, Method: Composition-based stats. Identities = 175/477 (36%), Positives = 278/477 (58%), Gaps = 4/477 (0%) Query: 28 AARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAG 87 + + PR P+ +P N WL L WRE+G + +H + FQ+ GPI+R LG Sbjct: 3 STKTPR---PYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLE 59 Query: 88 MVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPE 147 V ++ PEDV L + + +P R + PW+AY ++ GV W+ +R+ LN E Sbjct: 60 SVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTE 119 Query: 148 VLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGE 207 V++P A++ F+P+++ V++DF L K++ Q G D++ +FH+ E+ +FGE Sbjct: 120 VMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGE 179 Query: 208 RLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYG 267 RLG++ + + + F+ A+ MF ++V L+ +P L R K W++H AWD IF Sbjct: 180 RLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKA 239 Query: 268 DNCIQKIYQELAFSRP-QQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMT 326 + + YQ+L + Y I+ LL + ++ + +KAN E+ AG V+TT L Sbjct: 240 EKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWH 299 Query: 327 LFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVA 386 L+E+AR+ NVQ+ LR+E L A K +PLL+A++KETLRL+P+ + L+R Sbjct: 300 LYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYP 359 Query: 387 SSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFG 446 SDLVLQ+Y IPA TLV+V +Y++GR+PA F P++++P RWL +F ++ FG+G Sbjct: 360 ESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWG 419 Query: 447 MRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN 503 +RQC+GRR+AE EM L L H+L++ +VE D+ +++ IL P L FR N Sbjct: 420 VRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLILTPDKPIFLVFRPFN 476 >3K9V-A nrPDB Length = 482 Score = 414 bits (1064), Expect = e-116, Method: Composition-based stats. Identities = 133/461 (28%), Positives = 220/461 (47%), Gaps = 9/461 (1%) Query: 44 RPGNRWL---RLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKL 100 W LL+I+ + G + H + + ++ G IFR LG V + P +E L Sbjct: 27 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEAL 86 Query: 101 QQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPM 160 + +S HP R+ ++PW AYR HR G+ +L G EW+ R +++ P + + Sbjct: 87 YRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMKLDKK 146 Query: 161 VDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSAS 220 ++ V DF + + + L + RG + D+ + ++ E+ L L+ +R GL+ + Sbjct: 147 INEVLADFLERMDE--LCDERGRIP-DLYSELNKWSFESICLVLYEKRFGLLQKETEEEA 203 Query: 221 LNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF 280 L F+ A++ M + ++M P L + + KVW+ H AWD IF+ CI Q + Sbjct: 204 LTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYS- 262 Query: 281 SRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQAL 340 Q + ++ LS + A EL +V+TT L+ L+ L+RNP Q+ L Sbjct: 263 --QQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRL 320 Query: 341 RQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAG 400 QE + + +P L+A LKE++RL P F R VL Y +P G Sbjct: 321 LQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGEYALPKG 380 Query: 401 TLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEM 460 T++ + LG + F ++ P+RWL F H+PFG G R C+GRRLAE ++ Sbjct: 381 TVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIGRRLAELQL 440 Query: 461 LLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRA 501 L L +++ + E ++M++ IL PS + FR Sbjct: 441 HLALCWIIQKYDIVATDNEPVEMLHLGILVPSRELPIAFRP 481 >3E6I-A nrPDB Length = 476 Score = 327 bits (839), Expect = 6e-90, Method: Composition-based stats. Identities = 108/447 (24%), Positives = 169/447 (37%), Gaps = 38/447 (8%) Query: 73 QELGPIFRYDLGGAGMVCVMLPEDV-EKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFL 131 Q GP+F +G MV + + V E L R L + A+R G+ Sbjct: 41 QRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDR-----GIIF 95 Query: 132 LNGPEWR-FNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQP 190 NGP W+ R L Q + A +AL+K Q + + P Sbjct: 96 NNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAP 155 Query: 191 SI----------FHYTIEA--SNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLM 238 F Y E + LF E L+ NF L + S +++ Sbjct: 156 CNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVI 215 Query: 239 FMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAE 298 + + S +V KEH ++ D NC + + L ++ S AE L Sbjct: 216 KNVAEVKEYVSERV-KEHHQSLD------PNCPRDLTDCLLVEMEKEKHS--AERL---- 262 Query: 299 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKA 358 + D I +L +TT L L L + P +++ L +E K Sbjct: 263 YTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKD 322 Query: 359 TTELPLLRAALKETLRLYP-VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALF 417 E+P + A + E R V L A+ D + + Y IP GT+V L S+ + F Sbjct: 323 RQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEF 382 Query: 418 PRPERYNPQRWLDIRGSGR-NFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETL 476 P PE++ P+ +L+ G + + Y PF G R C G LA E+ LLL +L+H ++ L Sbjct: 383 PDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPL 442 Query: 477 TQE---DIKMVY-SFILRPSMFPLLTF 499 D+ ++ F P + L Sbjct: 443 VDPKDIDLSPIHIGFGCIPPRYKLCVI 469 >3DL9-A nrPDB Length = 479 Score = 324 bits (829), Expect = 8e-89, Method: Composition-based stats. Identities = 103/457 (22%), Positives = 178/457 (38%), Gaps = 40/457 (8%) Query: 65 HLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDV-EKLQQVDSLHPHRMSLEPWVAYRQHR 123 H+ + + Q G IF DLGG V + + V E L + R L ++ + Sbjct: 37 HVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMG 96 Query: 124 GHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALK--KKVLQNAR 181 G LLN R+ R ++ L+ N+ + F + + K ++ + Sbjct: 97 G------LLNS---RYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYK 147 Query: 182 GSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQL---- 237 G D + I + +NL +FGER + +F H +E +F V+L Sbjct: 148 GR-PFDFKQLITNAVSNITNLIIFGERF-------TYEDTDFQHMIE-LFSENVELAASA 198 Query: 238 -MFMPRSLSRWTSPKVWKEH---FEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAEL 293 +F+ + W + +H F ++ + I+K PQ + + Sbjct: 199 SVFLYNAFP-WIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDE 257 Query: 294 LLNAELSP------DAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAA 347 + + P + + + EL +TT L + +A PN+Q +++E Sbjct: 258 MDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLI 317 Query: 348 AASISEHPQKATTELPLLRAALKETLRLYPVGL-FLERVASSDLVLQNYHIPAGTLVRVF 406 + ++P A L E LR + + S D V++ Y IP GT V Sbjct: 318 MGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITN 377 Query: 407 LYSLGRNPALFPRPERYNPQRWLDIRGS-GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLH 465 LYS+ + + PE ++P+R+LD G + VPF G R CLG LA EM L Sbjct: 378 LYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFT 437 Query: 466 HVLKHLQVETLTQ--EDIKMVYSFILRPSMFPLLTFR 500 +L+ + + D+K L+P + + R Sbjct: 438 ALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAER 474 >3MDV-A nrPDB Length = 456 Score = 303 bits (777), Expect = 9e-83, Method: Composition-based stats. Identities = 93/448 (20%), Positives = 169/448 (37%), Gaps = 17/448 (3%) Query: 58 EQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEK-LQQVDSLHPHRMSLEPW 116 E G L ++ GP+ R ++ V V PE V+K L +M Sbjct: 6 EVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQ 65 Query: 117 VAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKV 176 + + + V N W R R+ S +++ + + A + L+ K Sbjct: 66 TVFGERLFGQGLVSECNYERWHKQR-RVIDLAFSRSSLVSLMETFNEKAEQLVEILEAK- 123 Query: 177 LQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQ 236 A G + +Q + + ++ A FG ++ + S LE + S Sbjct: 124 ---ADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNT 180 Query: 237 LMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLN 296 L K +E E+ + Q G + +Q+ + A R ++ + + +L Sbjct: 181 LAKFLPG-----KRKQLREVRESIRFLRQVGRDWVQRRRE--ALKRGEEVPADILTQILK 233 Query: 297 AE---LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISE 353 AE + + N + +T+ L T+ EL+R P + L+ E S Sbjct: 234 AEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRY 293 Query: 354 HPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRN 413 + L L LKE+LRLYP R+ + ++ +P T + Y +GR Sbjct: 294 LDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRM 353 Query: 414 PALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV 473 F P +NP R+ F + PF G R C+G++ A+ E+ +++ +L+ L+ Sbjct: 354 DTYFEDPLTFNPDRF-GPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEF 412 Query: 474 ETLTQEDIKMVYSFILRPSMFPLLTFRA 501 + + + L+P L T R Sbjct: 413 RLVPGQRFGLQEQATLKPLDPVLCTLRP 440 >5W0C-A nrPDB Length = 477 Score = 282 bits (722), Expect = 2e-76, Method: Composition-based stats. Identities = 95/487 (19%), Positives = 173/487 (35%), Gaps = 40/487 (8%) Query: 27 RAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGA 86 + R LP P +LQI G +D+ + + GP+F G Sbjct: 3 KKTSSGRGKLPPGPTPLPVIG---NILQI----GIKDISKSLTNLSKVYGPVFTLYFGLK 55 Query: 87 GMVCVMLPEDV-EKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWR-FNRLRL 144 +V + E V E L + R + G+ NG +W+ R L Sbjct: 56 PIVVLHGYEAVKEALIDLGEEFSGRGIFPL----AERANRGFGIVFSNGKKWKEIRRFSL 111 Query: 145 NPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPS------IFHYTIE 198 + V AR + L+K + L P IFH + Sbjct: 112 MTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFD 171 Query: 199 ASNLALFG------ERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKV 252 + E + ++ NF ++ + +L+ + + KV Sbjct: 172 YKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKV 231 Query: 253 WKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELT 312 KEH E+ D N Q ++ + +E + ++++ +++L Sbjct: 232 -KEHQESMDM------NNPQDFIDCFLMKMEKEKHN------QPSEFTIESLENTAVDLF 278 Query: 313 AGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKET 372 +TT L L L ++P V +++E + + +P A + E Sbjct: 279 GAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEV 338 Query: 373 LRLYPVGLF-LERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDI 431 R + L + D+ +NY IP GT + + L S+ + FP PE ++P +LD Sbjct: 339 QRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDE 398 Query: 432 RGS-GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILR 490 G+ ++ Y +PF G R C+G LA E+ L L +L++ +++L + Sbjct: 399 GGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNG 458 Query: 491 PSMFPLL 497 + P Sbjct: 459 FASVPPF 465 >4GQS-A nrPDB Length = 477 Score = 278 bits (711), Expect = 4e-75, Method: Composition-based stats. Identities = 94/487 (19%), Positives = 165/487 (33%), Gaps = 40/487 (8%) Query: 27 RAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGA 86 + R LP P +LQI +D+ + + GP+F G Sbjct: 3 KKTSSGRGKLPPGPTPLPVIG---NILQI----DIKDVSKSLTNLSKIYGPVFTLYFGLE 55 Query: 87 GMVCVMLPEDV-EKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWR-FNRLRL 144 MV + E V E L + R + G+ NG W+ R L Sbjct: 56 RMVVLHGYEVVKEALIDLGEEFSGRGHFPL----AERANRGFGIVFSNGKRWKEIRRFSL 111 Query: 145 NPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSI----------FH 194 + V AR + L+K + L P F Sbjct: 112 MTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFD 171 Query: 195 YTIEASNLAL--FGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKV 252 Y + + E + +V NF ++ + +L+ + KV Sbjct: 172 YKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKV 231 Query: 253 WKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELT 312 KEH E+ D N + ++ + +E + + + + +L Sbjct: 232 -KEHQESMDI------NNPRDFIDCFLIKMEKEKQN------QQSEFTIENLVITAADLL 278 Query: 313 AGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKET 372 +TT L L L ++P V +++E + +P A + E Sbjct: 279 GAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEV 338 Query: 373 LRLYP-VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDI 431 R + L + D+ +NY IP GT + L S+ + FP PE ++P+ +LD Sbjct: 339 QRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDE 398 Query: 432 RGS-GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILR 490 G+ ++ Y +PF G R C+G LA E+ L L +L++ +++L + Sbjct: 399 GGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNG 458 Query: 491 PSMFPLL 497 + P Sbjct: 459 FASVPPF 465 >2NNH-A nrPDB Length = 476 Score = 274 bits (701), Expect = 6e-74, Method: Composition-based stats. Identities = 88/471 (18%), Positives = 157/471 (33%), Gaps = 42/471 (8%) Query: 24 LGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDL 83 + + + + LP P +LQI +D+ + GP+F Sbjct: 1 MAKKTSS--KGKLPPGPTPLPIIG---NMLQI----DVKDICKSFTNFSKVYGPVFTVYF 51 Query: 84 GGAGMVCVMLPEDV-EKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWR-FNR 141 G +V E V E L R + Q G+ NG W+ R Sbjct: 52 GMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPI----SQRITKGLGIISSNGKRWKEIRR 107 Query: 142 LRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSI--------- 192 L + V A + L+K + L P Sbjct: 108 FSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQK 167 Query: 193 -FHYTIEASNLAL--FGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTS 249 F Y + + F E ++ NF ++ + +++ + Sbjct: 168 RFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIR 227 Query: 250 PKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSM 309 KV KEH + D N + Q+ + +E + + + Sbjct: 228 EKV-KEHQASLDV------NNPRDFIDCFLIKMEQEKDN------QKSEFNIENLVGTVA 274 Query: 310 ELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAAL 369 +L +TT L L L ++P V +++E + + +P A + Sbjct: 275 DLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVV 334 Query: 370 KETLRLYP-VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRW 428 E R V + ++D +NY IP GT + L S+ + FP P ++P + Sbjct: 335 HEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHF 394 Query: 429 LDIRGS-GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQ 478 LD G+ ++ Y +PF G R C G LA E+ L L +L++ ++++ Sbjct: 395 LDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDD 445 >1N6B-A nrPDB Length = 473 Score = 273 bits (697), Expect = 2e-73, Method: Composition-based stats. Identities = 99/496 (19%), Positives = 178/496 (35%), Gaps = 55/496 (11%) Query: 24 LGTRAA---RVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFR 80 + + + ++P PF + +LQI +D+ + + + GP+F Sbjct: 1 MAKKTSSKGKLPPGPTPFPIIG--------NILQI----DAKDISKSLTKFSECYGPVFT 48 Query: 81 YDLGGAGMVCVMLPEDV-EKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRF 139 LG V + E V E L + R S+ + G+ N W+ Sbjct: 49 VYLGMKPTVVLHGYEAVKEALVDLGEEFAGRGSVPIL----EKVSKGLGIAFSNAKTWKE 104 Query: 140 -NRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSI------ 192 R L + + AR + L+K + L P Sbjct: 105 MRRFSLMTLRNFGMGKRSIEDRIQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVI 164 Query: 193 ----FHYTIEASNLAL--FGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSR 246 F Y E + E + L+G NF L+ L+ + Sbjct: 165 FHNRFDYKDEEFLKLMESLHENVELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKN 224 Query: 247 WTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKA 306 + KV KEH + D N + Q+ N E + +++ Sbjct: 225 FIMEKV-KEHQKLLDV------NNPRDFIDCFLIKMEQEN---------NLEFTLESLVI 268 Query: 307 NSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLR 366 +L +TT L +L L ++P V +++E + + +P Sbjct: 269 AVSDLFGAGTETTSTTLRYSLLLLLKHPEVAARVQEEIERVIGRHRSPCMQDRSRMPYTD 328 Query: 367 AALKETLRLYPVGLF-LERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNP 425 A + E R + L + D+ +NY IP GT + L S+ + FP P+ ++P Sbjct: 329 AVIHEIQRFIDLLPTNLPHAVTRDVRFRNYFIPKGTDIITSLTSVLHDEKAFPNPKVFDP 388 Query: 426 QRWLDIRGS-GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLT-QEDIK- 482 +LD G+ ++ Y +PF G R C+G LA E+ L L +L++ ++++L +D+ Sbjct: 389 GHFLDESGNFKKSDYFMPFSAGKRMCVGEGLARMELFLFLTSILQNFKLQSLVEPKDLDI 448 Query: 483 --MVYSFILRPSMFPL 496 +V F+ P + L Sbjct: 449 TAVVNGFVSVPPSYQL 464 >6C94-A nrPDB Length = 497 Score = 270 bits (690), Expect = 9e-73, Method: Composition-based stats. Identities = 85/393 (21%), Positives = 159/393 (40%), Gaps = 38/393 (9%) Query: 128 GVFLLNGPEWRFNRLRLNP----EVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGS 183 G+ +L+GP+W +R L P +VL P A+ D ++ + +K + A Sbjct: 103 GLLVLDGPKWFQHRKLLTPGFHYDVLKPYV---------AIFADSTRIMLEKWEKKACEG 153 Query: 184 LTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRS 243 + D+ + H ++ FG+ + H SS + + L ++ + + Sbjct: 154 KSFDIFSDVGHMALDTLMKCTFGKGDSGLNHRDSSYYVA-VSELTLLMQQRIDSFQYHND 212 Query: 244 LSRWTSPKVWKEHFEAWDCIFQYGDNCI---------QKIYQELAFSRPQQYTSIVAELL 294 W +P + A + D I +K +++ R + I+ ++ Sbjct: 213 FIYWLTPH-GRRFLRACRAAHDHTDRVIRQRKAALQDEKEREKIQNRRHLDFLDILLDVR 271 Query: 295 LNA--ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASIS 352 + +LS ++A DTT + L+ +A P QQ R+E Sbjct: 272 GESGVQLSDTDLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQRCREEVREILGDQD 331 Query: 353 EHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVL-QNYHIPAGTLVRVFLYSLG 411 + ++ L +KE RLYP + R S + +PAG+L+ + +Y+L Sbjct: 332 SFQWEDLAKMTYLTMCMKECFRLYPPVPQVYRQLSKPVSFVDGRSLPAGSLISLHIYALH 391 Query: 412 RNPALFPRPERYNPQRWLDIRGSGRNFY-HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKH 470 RN ++P PE ++P R+ SGR+ Y +PF G R C+G++ A EM ++ L Sbjct: 392 RNSDVWPDPEVFDPLRFSPENSSGRHPYAFIPFSAGPRNCIGQQFAMNEMKVVTALCLLR 451 Query: 471 LQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN 503 + + +++ P P L R+ N Sbjct: 452 FEFSV---DPLRL-------PIKLPQLVLRSKN 474 >6HQW-A nrPDB Length = 445 Score = 265 bits (678), Expect = 3e-71, Method: Composition-based stats. Identities = 80/401 (19%), Positives = 157/401 (39%), Gaps = 42/401 (10%) Query: 109 HRMSLEPWVAYRQHRGHKCGVFLLNGPE-----WRFNRLRLN--PEVLSPNAV-QRFLPM 160 +R+ P+ AY HK + + + PE W++ + + PE + P + +R LPM Sbjct: 69 NRVPDSPYGAYWNVASHKAIMHVESLPELFSSSWQYGGITIGDPPEDVDPQKLAERQLPM 128 Query: 161 VDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSAS 220 A+ R ++ V + ++++ I T + +GER V + Sbjct: 129 FIAMDRPDHTGQRRTVAPAFTPAKMVEMEAEIRRRTASVLDSLPWGERFDWVDKVSIELT 188 Query: 221 LNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF 280 L L + +L+ S W E D F + + +Q L Sbjct: 189 TGMLAILFGFPWADRRLLTF---WSDWAGDVELTLARELADTRFGFL-GEMAHYFQRLWG 244 Query: 281 SRPQ-QYTSIVAELLLNAE----LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPN 335 +R Q + + +++++E +SP N + L G DTT + + L + P+ Sbjct: 245 ARMQAPPSGDLISMMIHSEAMNHMSPQEFMGNLVLLIVGGNDTTRNTMSGIVHALDKFPD 304 Query: 336 VQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNY 395 ++ L +++ L+ A++E +R + R A++D L Sbjct: 305 QRELLERDA------------------SLIPNAVQECIRYVTPLAHMRRTATADTELFGN 346 Query: 396 HIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRL 455 I AG V ++ S R+ +F P++ R H+ FG G+ +C+G RL Sbjct: 347 QIKAGEKVILWYISANRDETVFENPDKLMVDR-------PNARRHLSFGHGIHRCVGARL 399 Query: 456 AEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPL 496 AE ++ +LL + + + E ++ +F+ + Sbjct: 400 AELQLRILLEEMHERRMRVRVAGEVERVRANFVHGFRKLEV 440 >5E0E-A nrPDB Length = 463 Score = 258 bits (660), Expect = 3e-69, Method: Composition-based stats. Identities = 76/423 (17%), Positives = 149/423 (35%), Gaps = 22/423 (5%) Query: 73 QELGPIFRYDLGGAGMVCVMLPEDV-EKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFL 131 ++ G +F LG +V + E + E L R ++ A + GV Sbjct: 32 EKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI----AVVEPIFRGYGVVF 87 Query: 132 LNGPEWR-FNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQP 190 NG W+ R L + + AR + +K + Sbjct: 88 ANGERWKALRRFSLVTMRDFGMGKRSVEERIQEEARCLVEEFRKSQGAPLDPTFLFQC-- 145 Query: 191 SIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSP 250 T +FGER H F + ++ + Q+ + ++ P Sbjct: 146 ----ITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFSGFLKYF-P 200 Query: 251 KVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLL------NAELSPDAI 304 ++ I Y ++K L S P+ + + + E + Sbjct: 201 GTHRQISRNLQEILDYIGQSVEKHRATLDPSHPRDFIDTYLLRMEKEKSNQHTEFDHQNL 260 Query: 305 KANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPL 364 + + L +T+ L + + P+V + +++E S + T++P Sbjct: 261 VISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLEDRTKMPY 320 Query: 365 LRAALKETLRLYP-VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERY 423 A + E R + + + + D + + Y +P T V L S +P F +P+ + Sbjct: 321 TEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQYFEQPDTF 380 Query: 424 NPQRWLDIRGS-GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV-ETLTQEDI 481 NP +LD G+ ++ +PF G R CLG +A E+ L +L++ + + +DI Sbjct: 381 NPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSLSSPVAPKDI 440 Query: 482 KMV 484 + Sbjct: 441 DLS 443 >4H1N-A nrPDB Length = 479 Score = 257 bits (656), Expect = 9e-69, Method: Composition-based stats. Identities = 89/472 (18%), Positives = 161/472 (34%), Gaps = 31/472 (6%) Query: 24 LGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDL 83 + + + + +P LLQ+ R+ G L + + + G +F L Sbjct: 1 MAKKTSSKGKLPPGPSPLPVLG-----NLLQMDRK-GLLRSFLRLRE---KYGDVFTVYL 51 Query: 84 GGAGMVCVMLPEDV-EKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWR-FNR 141 G +V + + + E L R + A GV NG WR R Sbjct: 52 GSRPVVVLCGTDAIREALVDQAEAFSGRGKI----AVVDPIFQGYGVIFANGERWRALRR 107 Query: 142 LRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASN 201 L + + AR + L+K +L T Sbjct: 108 FSLATMRDFGMGKRSVEERIQEEARCLVEELRKSKGALLDNTLLF------HSITSNIIC 161 Query: 202 LALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWD 261 +FG+R F + ++ + Q+ + ++ P ++ + Sbjct: 162 SIVFGKRFDYKDPVFLRLLDLFFQSFSLISSFSSQVFELFSGFLKYF-PGTHRQIYRNLQ 220 Query: 262 CIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLN------AELSPDAIKANSMELTAGS 315 I + ++K L S P+ + + + +E + + L A Sbjct: 221 EINTFIGQSVEKHRATLDPSNPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAG 280 Query: 316 VDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRL 375 +TT L + + P+V + +++E S ++P A + E RL Sbjct: 281 TETTSTTLRYGFLLMLKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRL 340 Query: 376 YPVGLF-LERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGS 434 + F + + D + Y IP T V L S +P F P +NP +LD G+ Sbjct: 341 GDLIPFGVPHTVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGA 400 Query: 435 -GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQV-ETLTQEDIKMV 484 RN +PF G R CLG +A E+ L +L++ + + EDI + Sbjct: 401 LKRNEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDLT 452 >5E58-A nrPDB Length = 493 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 83/445 (18%), Positives = 155/445 (34%), Gaps = 26/445 (5%) Query: 51 RLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDV-EKLQQVDSLHPH 109 LLQ+ R G+ + + + + + G +F LG +V + E + E L Sbjct: 42 NLLQMDR-GGFLNSFMRIRE---KYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSG 97 Query: 110 RMSLEPWVAYRQHRGHKCGVFLLNGPEWRF-NRLRLNPEVLSPNAVQRFLPMVDAVARDF 168 R ++ A + G+ NG W+ R L + + A+ Sbjct: 98 RGTI----AVIKPVIGDYGMIFSNGERWKVLRRFSLATMRDFGMGKRSVEDRIQEEAQCL 153 Query: 169 SQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALE 228 + L+K + T +FGER L+ + Sbjct: 154 VEELQKSQGAPLDPTFLFQC------ITANIICSIVFGERYDYKDRQFLRL-LDLFYRTF 206 Query: 229 VMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTS 288 + S +F S P ++ I Y ++K L S P+ + Sbjct: 207 SLMSSFSSQVFELFSGFMKYFPGAHRQITRNLQEILDYVGQSVEKHRATLDPSNPRDFID 266 Query: 289 IVAELLL------NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQ 342 + + E + + + L +TT L + + P+V + +++ Sbjct: 267 TYLLRMEKEKSNQHTEFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQK 326 Query: 343 ESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLF-LERVASSDLVLQNYHIPAGT 401 E S + T++P A + E R + + D + + Y +P T Sbjct: 327 EIDQVIGSHRLPTLEDRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNT 386 Query: 402 LVRVFLYSLGRNPALFPRPERYNPQRWLDIRGS-GRNFYHVPFGFGMRQCLGRRLAEAEM 460 V L S +P F +P +NP +LD G+ ++ +PF G R CLG +A E+ Sbjct: 387 EVYPILSSALHDPQYFEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNEL 446 Query: 461 LLLLHHVLKHLQV-ETLTQEDIKMV 484 L +L++ V ++ +DI + Sbjct: 447 FLFFTTILQNFSVSSSVAPKDIDLS 471 >3IBD-A nrPDB Length = 476 Score = 254 bits (648), Expect = 7e-68, Method: Composition-based stats. Identities = 84/461 (18%), Positives = 155/461 (33%), Gaps = 26/461 (5%) Query: 51 RLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDV-EKLQQVDSLHPH 109 LLQ+ R G L + + G +F LG +V + E + E L Sbjct: 23 NLLQMDRR-GLLKSFLRFRE---KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSG 78 Query: 110 RMSLEPWVAYRQHRGHKCGVFLLNGPEWRF-NRLRLNPEVLSPNAVQRFLPMVDAVARDF 168 R + A GV NG W+ R + + + A+ Sbjct: 79 RGKI----AMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCL 134 Query: 169 SQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALE 228 + L+K + T +FG+R F Sbjct: 135 IEELRKSKGALMDPTFLFQ------SITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFS 188 Query: 229 VMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTS 288 ++ QL + + P ++ ++ I Y + ++K + L S P+ Sbjct: 189 LISSVFGQLFELFSGFLKHF-PGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLID 247 Query: 289 IVAELL------LNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQ 342 + ++E S + N++ L +TT L + + P+V + + + Sbjct: 248 TYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYR 307 Query: 343 ESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLF-LERVASSDLVLQNYHIPAGT 401 E ++P A + E R + + + + + Y IP T Sbjct: 308 EIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDT 367 Query: 402 LVRVFLYSLGRNPALFPRPERYNPQRWLDIRGS-GRNFYHVPFGFGMRQCLGRRLAEAEM 460 V + L + +P F +P+ +NP +LD G+ + +PF G R CLG +A AE+ Sbjct: 368 EVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAEL 427 Query: 461 LLLLHHVLKHLQV-ETLTQEDIKMVYSFILRPSMFPLLTFR 500 L +L++ + + EDI + + P R Sbjct: 428 FLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIR 468 >4WMZ-A nrPDB Length = 539 Score = 253 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 87/455 (19%), Positives = 166/455 (36%), Gaps = 51/455 (11%) Query: 73 QELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLL 132 ++ G IF + L G M + P+ E + + + K ++ Sbjct: 85 KKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAK--LADVSAEAAYAHLTTPVFGKGVIYDC 142 Query: 133 NGPEWRFNRLRLNPEVLSPNAVQRFLPMV-DAVARDFSQALKKKVLQNARGSLTLDVQPS 191 + L+ A + ++P++ + V + F + K N R + T+DV + Sbjct: 143 PNSRLMEQKK-FVKGALTKEAFKSYVPLIAEEVYKYFRDS--KNFRLNERTTGTIDVMVT 199 Query: 192 IFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPK 251 TI ++ +L G+ + + +F + + K + F+ P Sbjct: 200 QPEMTIFTASRSLLGKEMR------AKLDTDFAYLYSDLDKGFTPINFV--------FPN 245 Query: 252 VWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNA------ELSPDAIK 305 + EH+ D + + +E + Q ++ L+ N+ +++ I Sbjct: 246 LPLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIA 305 Query: 306 ANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAA-ASISEHPQKATTELPL 364 + + G T+ L LA P+VQQ L +E + E E+PL Sbjct: 306 NLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPL 365 Query: 365 LRAALKETLRLYPVGLFLERVASSDLVLQN--YHIPAGTLVRVFLYSLGRNPALFPRPER 422 L +KETLR++ L R D+ + N Y IPAG V V FP + Sbjct: 366 LNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQ 425 Query: 423 YNPQRWLDIRGS-----------------GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLH 465 +N RW + S G + ++PFG G +C+G A ++ +L+ Sbjct: 426 FNIHRWNNDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMS 485 Query: 466 HVLKHLQV-----ETLTQEDIKMVYSFILRPSMFP 495 ++ L+ +T+ D + + P+ Sbjct: 486 IFIRTLKWHYPEGKTVPPPDFTSMVTLPTGPAKII 520 >5JLC-A nrPDB Length = 515 Score = 253 bits (647), Expect = 1e-67, Method: Composition-based stats. Identities = 85/446 (19%), Positives = 159/446 (35%), Gaps = 47/446 (10%) Query: 73 QELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLL 132 ++ G IF + L G M + P+ E + + + K ++ Sbjct: 67 KKYGDIFSFMLLGRIMTVYLGPKGHEFIFNAK--LADVSAEAAYSHLTTPVFGKGVIYDC 124 Query: 133 NGPEWRFNRLRLNPEVLSPNAVQRFLPMV-DAVARDFSQALKKKVLQNARGSLTLDVQPS 191 + + L+ A R++P++ + + + F + K+ +N G +DV S Sbjct: 125 PNHRLMEQKKFV-KGALTKEAFVRYVPLIAEEIYKYFRNSKNFKINENNSG--IVDVMVS 181 Query: 192 IFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPK 251 TI ++ +L G+ + +F + + K + F+ P Sbjct: 182 QPEMTIFTASRSLLGKEMR------DKLDTDFAYLYSDLDKGFTPINFV--------FPN 227 Query: 252 VWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNA------ELSPDAIK 305 + EH+ D Q + +E Q ++ EL+ N+ +++ I Sbjct: 228 LPLEHYRKRDHAQQAISGTYMSLIKERREKNDIQNRDLIDELMKNSTYKDGTKMTDQEIA 287 Query: 306 ANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAA-SISEHPQKATTELPL 364 + + G T+ L LA P+VQ+ L QE + E +PL Sbjct: 288 NLLIGVLMGGQHTSAATSAWCLLHLAERPDVQEELYQEQMRVLNNDTKELTYDDLQNMPL 347 Query: 365 LRAALKETLRLYPVGLFLERVASSDLVLQN--YHIPAGTLVRVFLYSLGRNPALFPRPER 422 L +KETLRL+ L R D+ + N Y +P V V FP+P Sbjct: 348 LNQMIKETLRLHHPLHSLFRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNE 407 Query: 423 YNPQRWLDIRGS------------------GRNFYHVPFGFGMRQCLGRRLAEAEMLLLL 464 +N RW S G + ++PFG G +C+G A ++ +L+ Sbjct: 408 FNIHRWDGDAASSSAAGGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLM 467 Query: 465 HHVLKHLQVETLTQEDIKMVYSFILR 490 ++ ++ T+ + F Sbjct: 468 SIFIRTMKWRYPTEGETVPPSDFTSM 493 >6B82-A nrPDB Length = 509 Score = 252 bits (644), Expect = 2e-67, Method: Composition-based stats. Identities = 91/460 (19%), Positives = 165/460 (35%), Gaps = 44/460 (9%) Query: 65 HLEVHQTFQELGPIFRYDLGGAGMVCVM-LPEDVEKLQQVDSLHPHRMSLEPWVAYRQH- 122 H+ ++ G ++ +G ++ V E L + + R P Sbjct: 47 HIFFQDLQKKYGDLYSLMMGSHKLLIVNNHHHAKEILIKKGKIFAGR----PRTVTTDLL 102 Query: 123 -RGHKCGVFLLNGPEWRFNRLRL-NPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNA 180 R K F W+F+R + + ++ A + L + Sbjct: 103 TRDGKDIAFADYSSTWKFHRKMVHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSA- 161 Query: 181 RGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFM 240 +D+ P + F S F L+ + Sbjct: 162 -----VDLGPELTRAVTNVVCALCFN-------SSYKRGDAEFESMLQYSQGIVDTVAKD 209 Query: 241 -PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAE- 298 + W K+ CI D +QK Y+E + + + LL A+ Sbjct: 210 SLVDIFPWLQIFPNKDLRILRQCI-SIRDKLLQKKYEEHKVTYSDNVQRDLLDALLRAKR 268 Query: 299 -------------LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESL 345 L+ D + E+ V+TT L ++ L NP VQ+ +++E Sbjct: 269 SSENNNSSTRDVGLTEDHVLMTVGEIFGAGVETTTTTLKWSIAYLVHNPQVQRKIQEELD 328 Query: 346 AAAASISEHPQKATTELPLLRAALKETLRLYPVGL-FLERVASSDLVLQNYHIPAGTLVR 404 + LP L A + E +R+ PV + VA D + Y + GT V Sbjct: 329 SKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVV 388 Query: 405 VFLYSLGRNPALFPRPERYNPQRWLDIRGSG---RNFYHVPFGFGMRQCLGRRLAEAEML 461 + ++SL + + PE ++P R+L+ G G + ++PFG G+R CLG LA+ E+ Sbjct: 389 INMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELF 448 Query: 462 LLLHHVLKHLQVETLTQE---DIKMVYSFILRPSMFPLLT 498 L L +L+ +E T + D++ + +L+P F ++ Sbjct: 449 LFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPKKFKVVA 488 >2PG7-A nrPDB Length = 476 Score = 251 bits (640), Expect = 6e-67, Method: Composition-based stats. Identities = 87/488 (17%), Positives = 168/488 (34%), Gaps = 40/488 (8%) Query: 24 LGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDL 83 + + + + LP P +L+L E ++ + + + GP+F L Sbjct: 1 MAKKTSS--KGKLPPGPTPLPFIGNYLQL-------NTEQMYNSLMKISERYGPVFTIHL 51 Query: 84 GGAGMVCVMLPEDV-EKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRF-NR 141 G +V + + V E L R + GV NG + R Sbjct: 52 GPRRVVVLCGHDAVREALVDQAEEFSGRGEQATF----DWVFKGYGVVFSNGERAKQLRR 107 Query: 142 LRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASN 201 + + + A AL+ N + L + Sbjct: 108 FSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLS------RTVSNVIS 161 Query: 202 LALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWD 261 +FG+R L+ L + +F+ T + + +A+ Sbjct: 162 SIVFGDRFDYKDK----EFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQ 217 Query: 262 CIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLL---------NAELSPDAIKANSMELT 312 + D +K+ P + L+ N E + +++L Sbjct: 218 LLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLF 277 Query: 313 AGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKET 372 G +T L L ++P V+ + +E + + ++P + A + E Sbjct: 278 VGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEI 337 Query: 373 LRLYPV-GLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDI 431 R V + L R D +++ +P GT V L S+ R+P+ F P+ +NPQ +L+ Sbjct: 338 QRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNE 397 Query: 432 RGS-GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE-TLTQEDIKM---VYS 486 +G ++ VPF G R C G LA E+ L V+++ +++ + + +DI + Sbjct: 398 KGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVG 457 Query: 487 FILRPSMF 494 F P + Sbjct: 458 FATIPRNY 465 >5VEU-A nrPDB Length = 480 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 94/448 (20%), Positives = 185/448 (41%), Gaps = 40/448 (8%) Query: 70 QTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVD--SLHPHRMSLEPWVAYRQHRGHKC 127 + +++ G ++ G ++ + P+ + + + S+ +R SL P K Sbjct: 42 ECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGP------VGFMKS 95 Query: 128 GVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLD 187 + L EW+ R L+P S + F + + L + + + A + Sbjct: 96 AISLAEDEEWKRIRSLLSPTFTSGKLKEMF-----PIIAQYGDVLVRNLRREAEKGKPVT 150 Query: 188 VQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFK-STVQLMFMPRSLSR 246 ++ Y+++ FG + + + F+ + + K + +F+ L Sbjct: 151 LKDIFGAYSMDVITGTSFGVNIDSLNNPQDP----FVESTKKFLKFGFLDPLFLSIILFP 206 Query: 247 WTSPKVWKEHFEAWDCIF------QYGDNCIQKIYQELAFSRPQQYTSIVAELLL----- 295 + +P FEA + + + ++ + + + + ++ Sbjct: 207 FLTP-----VFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSK 261 Query: 296 ----NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASI 351 + LS + A S+ +TT L TL+ELA +P+VQQ L++E A + Sbjct: 262 ETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNK 321 Query: 352 SEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLG 411 + A ++ L + ETLRL+PV + LER D+ + IP G++V + Y+L Sbjct: 322 APPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALH 381 Query: 412 RNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL 471 +P + PE + P+R+ + S + + PFG G R C+G R A M L L VL++ Sbjct: 382 HDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNF 441 Query: 472 QVETL--TQEDIKMVYSFILRPSMFPLL 497 + TQ +K+ +L+P +L Sbjct: 442 SFKPCKETQIPLKLDTQGLLQPEKPIVL 469 >6DA2-A nrPDB Length = 487 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 84/440 (19%), Positives = 177/440 (40%), Gaps = 23/440 (5%) Query: 70 QTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVD--SLHPHRMSLEPWVAYRQHRGHKC 127 + ++ G ++ + G ++ + P+ ++ + + S+ +R P K Sbjct: 43 ECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGP------VGFMKS 96 Query: 128 GVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLD 187 + + EW+ R L+P + ++ +P++ + L + + + A + Sbjct: 97 AISIAEDEEWKRLRSLLSP-TFTSGKLKEMVPII----AQYGDVLVRNLRREAETGKPVT 151 Query: 188 VQPSIFHYTIEASNLALFGERLGLVGHSPSS--ASLNFLHALEVMFKSTVQLMFMPRSLS 245 ++ Y+++ FG + + + + L + + + + P + Sbjct: 152 LKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIP 211 Query: 246 RWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAE-----LS 300 + E + + + + ++ R ++ LS Sbjct: 212 ILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALS 271 Query: 301 PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT 360 + A S+ +TT L ++ELA +P+VQQ L++E A + + Sbjct: 272 DLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL 331 Query: 361 ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP 420 ++ L + ETLRL+P+ + LERV D+ + IP G +V + Y+L R+P + P Sbjct: 332 QMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEP 391 Query: 421 ERYNPQRWLDIRGSGRNFY-HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETL--T 477 E++ P+R+ + Y + PFG G R C+G R A M L L VL++ + T Sbjct: 392 EKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET 451 Query: 478 QEDIKMVYSFILRPSMFPLL 497 Q +K+ +L+P +L Sbjct: 452 QIPLKLSLGGLLQPEKPVVL 471 >4R1Z-A nrPDB Length = 439 Score = 240 bits (612), Expect = 1e-63, Method: Composition-based stats. Identities = 88/426 (20%), Positives = 154/426 (36%), Gaps = 43/426 (10%) Query: 98 EKLQQVDSLHPHRMSLEPWVAYRQH--RGHKCGVFLLNGPEWRFNRLRL-NPEVLSPNAV 154 E L + + R P R K F W+F+R + + Sbjct: 17 EILIKKGKIFAGR----PRTVTTDLLTRDGKDIAFADYSSTWKFHRKMVHGALCMFGEGS 72 Query: 155 QRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGH 214 ++ A + L + +D+ P + F Sbjct: 73 VSIEKIICREASSMCEVLTESQNSA------VDLGPELTRAVTNVVCALCFN-------S 119 Query: 215 SPSSASLNFLHALEVMFKSTVQLMFM-PRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQK 273 S F L+ + + W K+ CI D +QK Sbjct: 120 SYKRGDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKDLTILRQCI-SIRDKLLQK 178 Query: 274 IYQELAFSRPQQYTSIVAELLLNAE--------------LSPDAIKANSMELTAGSVDTT 319 Y+E + + + LL A+ L+ D + ++ V+TT Sbjct: 179 KYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDIFGAGVETT 238 Query: 320 VFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVG 379 L ++ L NP VQ+ +++E + LP L A ++E LR+ PV Sbjct: 239 TTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIREVLRIRPVS 298 Query: 380 L-FLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSG--- 435 + VA D + Y + GT V + L+SL + + PE ++P R+L+ G G Sbjct: 299 PLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLNEEGDGLCC 358 Query: 436 RNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQE---DIKMVYSFILRPS 492 + ++PFG G+R CLG LA+ E+ L L +L+ +E T + D++ + +L+P Sbjct: 359 PSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPK 418 Query: 493 MFPLLT 498 F ++ Sbjct: 419 KFKVVA 424 >4R20-A nrPDB Length = 486 Score = 240 bits (612), Expect = 1e-63, Method: Composition-based stats. Identities = 87/447 (19%), Positives = 165/447 (36%), Gaps = 29/447 (6%) Query: 65 HLEVHQTFQELGPIFRYDLG-GAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHR 123 HL Q + GP+F G +V + E L Q R + Q Sbjct: 42 HLLFTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQ-- 99 Query: 124 GHKCGVFLLNGPEWRFNRLRLNPE-VLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARG 182 G K F P W+ +R ++ L + +V A + L A Sbjct: 100 GGKDIAFADYSPLWKNHRRLVHSSFTLFGEGSNKLQTIVQEAADSLCEEL------QACR 153 Query: 183 SLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPR 242 + D+ + +F + + + ++ + + Sbjct: 154 GQSSDLSVVLMRAVTNVICRLVFSSSY----QPSDPELQTVIQYNDGIVQTIARGGLV-- 207 Query: 243 SLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLN------ 296 + W K+ +C+ +K+ + P + ++ LL+ Sbjct: 208 DIFPWLRIFPNKDLKRLKECVSIRDQLLYKKLLEHKKSLTPGEPRDLLDALLIGQQRGSG 267 Query: 297 --AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEH 354 +++ D + + E V+TT LL T+ L +P +Q+ ++ E Sbjct: 268 GADDITEDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPP 327 Query: 355 PQKATTELPLLRAALKETLRLYPVGLF-LERVASSDLVLQNYHIPAGTLVRVFLYSLGRN 413 LPLL A L E +R+ PV + VA D L + +P GT V V ++++ + Sbjct: 328 CLSDRPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHD 387 Query: 414 PALFPRPERYNPQRWLDIRGSGRN-FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQ 472 P + +PE++NP+R+L+ G + +PFG G R C+G LA E+ L + L+ Sbjct: 388 PKHWDQPEQFNPERFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFS 447 Query: 473 VETLTQ---EDIKMVYSFILRPSMFPL 496 ++ D++ + +L+P + + Sbjct: 448 FSCPSEASLPDLQGRFGVVLQPERYTV 474 >5UYS-A nrPDB Length = 494 Score = 235 bits (599), Expect = 3e-62, Method: Composition-based stats. Identities = 90/448 (20%), Positives = 173/448 (38%), Gaps = 39/448 (8%) Query: 65 HLEVHQTF----QELGPIFRYDLGGAGMVCVMLPEDV-EKLQQVDSLHPHRMSLEPWVAY 119 H +H F ++ GPI+ +G V V + E L + R P +A Sbjct: 28 HGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGR----PQMAT 83 Query: 120 RQHR--GHKCGVFLLNGPEWRFN-RLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKV 176 K F +G W+ + RL + L + Q+ ++ L Sbjct: 84 LDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHN 143 Query: 177 LQNARGSLTLDVQPSI---------FHYTIEASNLALFGERLGLVGHSPSSASLNFLHAL 227 Q+ S + V + + + + G++ + + ++ + L Sbjct: 144 GQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWL 203 Query: 228 EVMFKSTVQLMFMPRSLSRWTSPKV---WKEHFEAWDCIFQYGDNCIQ-KIYQELAFSRP 283 ++ T++ + + K+ +KE F + D I D +Q K+ + + P Sbjct: 204 KIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRS-DSITNMLDTLMQAKMNSDNGNAGP 262 Query: 284 QQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE 343 Q + + LS + I ++ V+TT + TL L NP V++ L +E Sbjct: 263 DQDSEL---------LSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEE 313 Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLF-LERVASSDLVLQNYHIPAGTL 402 L LL A ++E LRL PV + A+ D + + + GT Sbjct: 314 IDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTE 373 Query: 403 VRVFLYSLGRNPALFPRPERYNPQRWLDIRGS---GRNFYHVPFGFGMRQCLGRRLAEAE 459 V + L++L N + +P+++ P+R+L+ G+ + ++PFG G R C+G LA E Sbjct: 374 VIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQE 433 Query: 460 MLLLLHHVLKHLQVETLTQEDIKMVYSF 487 + L++ +L+ +E + + Sbjct: 434 LFLIMAWLLQRFDLEVPDDGQLPSLEGI 461 >3TBG-A nrPDB Length = 479 Score = 225 bits (574), Expect = 3e-59, Method: Composition-based stats. Identities = 82/444 (18%), Positives = 154/444 (34%), Gaps = 28/444 (6%) Query: 70 QTFQELGPIFRYDLGGAGMVCVMLPEDV-EKLQQVDSLHPHRMSLEPWVAYRQHRGHKCG 128 Q + G +F L +V + V E L R + + Sbjct: 38 QLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGV 97 Query: 129 VFLLNGPEWR-FNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLD 187 GP WR R ++ + V A A + R + LD Sbjct: 98 FLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLD 157 Query: 188 VQPSIFHYTIEASNLALFGE----RLGLVGHSPSSASLNFLH----ALEVMFKSTVQLMF 239 S ++ + + RL + FL A+ V+ Sbjct: 158 KAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGK 217 Query: 240 MPRSLSRWTS--PKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNA 297 + R + + ++ EH WD D + E+ ++ + Sbjct: 218 VLRFQKAFLTQLDELLTEHRMTWDPAQPPRD-LTEAFLAEMEKAKGNP----------ES 266 Query: 298 ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQK 357 + + ++ +L + + TT L L + +P+VQ+ ++QE + Sbjct: 267 SFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMG 326 Query: 358 ATTELPLLRAALKETLRLYPVGL-FLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPAL 416 +P A + E R + + + S D+ +Q + IP GT + L S+ ++ A+ Sbjct: 327 DQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAV 386 Query: 417 FPRPERYNPQRWLDIRGS-GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVET 475 + +P R++P+ +LD +G + +PF G R CLG LA E+ L +L+H Sbjct: 387 WEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSV 446 Query: 476 LTQEDIKMVYS---FILRPSMFPL 496 T + + F++ PS + L Sbjct: 447 PTGQPRPSHHGVFAFLVSPSPYEL 470 >3RWL-A nrPDB Length = 426 Score = 224 bits (570), Expect = 8e-59, Method: Composition-based stats. Identities = 67/343 (19%), Positives = 117/343 (34%), Gaps = 32/343 (9%) Query: 158 LPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPS 217 LP A+ R +K V + ++ +I + + GE V Sbjct: 108 LPNFIAMDRPRHDEQRKAVSPIVAPANLAALEGTIRERVSKTLDGLPVGEEFDWVDRVSI 167 Query: 218 SASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNC---IQKI 274 + L L + + S T+ E+WD C Q + Sbjct: 168 EITTQMLATLFDFPFEERRKLT---RWSDVTTAAPGGGVVESWDQRKTELLECAAYFQVL 224 Query: 275 YQELAFSRP-QQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARN 333 + E P S++A ++P+ N + L G DTT + + L +N Sbjct: 225 WNERVNKDPGNDLISMLAHSPATRNMTPEEYLGNVLLLIVGGNDTTRNSMTGGVLALHKN 284 Query: 334 PNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQ 393 P+ L L+ + E +R + R A +D L Sbjct: 285 PDQFAKL------------------KANPALVETMVPEIIRWQTPLAHMRRTAIADSELG 326 Query: 394 NYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGR 453 I G V ++ YS R+ + RPE + R R H+ FGFG+ +C+G Sbjct: 327 GKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDR-------PRPRQHLSFGFGIHRCVGN 379 Query: 454 RLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPL 496 RLAE ++ +L +L + E ++ +F+ + + Sbjct: 380 RLAEMQLRILWEEILTRFSRIEVMAEPERVRSNFVRGYAKMMV 422 >5VBU-A nrPDB Length = 476 Score = 218 bits (554), Expect = 5e-57, Method: Composition-based stats. Identities = 94/440 (21%), Positives = 175/440 (39%), Gaps = 33/440 (7%) Query: 48 RWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVE-KLQQVDSL 106 +L LLQ DL + + Q+ GPI+R LG +V + +E + + + Sbjct: 17 GFLHLLQ-------PDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWAD 69 Query: 107 HPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVAR 166 R EP R + W+ ++ L L P+V+ + + Sbjct: 70 FAGRP--EPLTYKLVSRNYPDLSLGDYSLLWKAHKK-LTRSALLLGIRDSMEPVVEQLTQ 126 Query: 167 DFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHA 226 +F + ++ A+ + ++ T FG+++ + + Sbjct: 127 EFCERMR------AQPGTPVAIEEEFSLLTCSIICYLTFGDKIKD-DNLMPAYYKCIQEV 179 Query: 227 LEVMFKSTVQLMFMPRSLSRWTSP--KVWKEHFEAWDCI-----FQYGDNCIQKIYQELA 279 L+ ++Q++ + L + +P + K+ E D I Q+ ++ + ++++ Sbjct: 180 LKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMM 239 Query: 280 FSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQA 339 Q E + +L + +++L G +TT L + L +P +QQ Sbjct: 240 DYMLQGVAQPSMEE-GSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQR 298 Query: 340 LRQESL---AAAASISEHPQKATTELPLLRAALKETLRLYPVGL-FLERVASSDLVLQNY 395 L++E AS S P K LPLL A + E LRL PV L + + Y Sbjct: 299 LQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGY 358 Query: 396 HIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRL 455 IP GT++ L + ++ RP + P R+L+ G+N + FG G R CLG L Sbjct: 359 DIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEP---GKNSRALAFGCGARVCLGEPL 415 Query: 456 AEAEMLLLLHHVLKHLQVET 475 A E+ ++L +L+ + Sbjct: 416 ARLELFVVLTRLLQAFTLLP 435 >3QZ1-A nrPDB Length = 496 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 85/442 (19%), Positives = 168/442 (38%), Gaps = 35/442 (7%) Query: 48 RWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVE-KLQQVDSL 106 +L LLQ +L + + Q+LGP++R LG +V + +E + + Sbjct: 36 GFLHLLQ-------PNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVD 88 Query: 107 HPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVAR 166 R + + Q + L + +L L P VD + + Sbjct: 89 FAGRPQIPSYKLVSQRCQD---ISLGDYSLLWKAHKKLTRSALLLGTRSSMEPWVDQLTQ 145 Query: 167 DFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHA 226 +F + ++ + + +Q T FG + + H+ + + Sbjct: 146 EFCERMRVQA------GAPVTIQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQDLM-- 197 Query: 227 LEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQY 286 + ++Q++ M L + +P +W+ +A + + +++ + + + + Sbjct: 198 -KTWDHWSIQILDMVPFLRFFPNPGLWRLK-QAIENRDHMVEKQLRRHKESMVAGQWRDM 255 Query: 287 TSIVAELLLN-------AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQA 339 T + + + +L + + ++L G +TT L + L +P +Q+ Sbjct: 256 TDYMLQGVGRQRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRR 315 Query: 340 LRQESLAAAA---SISEHPQKATTELPLLRAALKETLRLYPVGL-FLERVASSDLVLQNY 395 L++E S S K LPLL A + E LRL PV L + + Y Sbjct: 316 LQEELDRELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGY 375 Query: 396 HIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRL 455 IP G +V L + ++ +P + P R+L+ G N + FG G R CLG L Sbjct: 376 DIPEGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEP---GANPSALAFGCGARVCLGESL 432 Query: 456 AEAEMLLLLHHVLKHLQVETLT 477 A E+ ++L +L+ + Sbjct: 433 ARLELFVVLARLLQAFTLLPPP 454 >6DWN-A nrPDB Length = 491 Score = 216 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 82/481 (17%), Positives = 164/481 (34%), Gaps = 56/481 (11%) Query: 44 RPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDV-EKLQQ 102 W + + ++ HL + + Q+ G + + +G +V + + + + L + Sbjct: 14 PGPWGWPLIGHMLTLG--KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVR 71 Query: 103 VDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRF----L 158 R L + G +GP W R L+ N ++ F Sbjct: 72 QGDDFKGRPDLYTFTLISN--GQSMSFSPDSGPVWAARR------RLAQNGLKSFSIASD 123 Query: 159 PM------VDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLG-- 210 P ++ ++ L + + G + + FG R Sbjct: 124 PASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHN 183 Query: 211 -------------LVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHF 257 S +F+ L + ++ K+ KEH+ Sbjct: 184 HQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHY 243 Query: 258 EAWD--CIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGS 315 + ++ I D+ I+ ++ N +LS + I ++L Sbjct: 244 KTFEKGHIRDITDSLIEHCQEKQLDEN------------ANVQLSDEKIINIVLDLFGAG 291 Query: 316 VDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRL 375 DT + +L L NP VQ+ +++E + LP + A + ET R Sbjct: 292 FDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRH 351 Query: 376 YPVGLF-LERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGS 434 F + + D L+ ++IP G V V + + + L+ P + P+R+L G+ Sbjct: 352 SSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGA 411 Query: 435 GR---NFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKH--LQVETLTQEDIKMVYSFIL 489 + + FG G R+C+G +A E+ L L +L+ V + D+ +Y + Sbjct: 412 IDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTM 471 Query: 490 R 490 + Sbjct: 472 K 472 >6AYB-A nrPDB Length = 466 Score = 213 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 76/433 (17%), Positives = 146/433 (33%), Gaps = 25/433 (5%) Query: 68 VHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHR--GH 125 + ++ G +F + G M + P+ ++ + L YR R Sbjct: 36 IIDNSKKYGDVFTATILGKEMTFLNHPKILDTFFKATDN-----ELSLRDVYRFMRPVFG 90 Query: 126 KCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLT 185 V+ + E +++ L+ + F+ + + + L T Sbjct: 91 TGVVYDADSTERMMEQVKFVSSGLTTARFRVFVDIFEDEIAHKVKEL--------GPEGT 142 Query: 186 LDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLS 245 +DV + I ++ L G+ + N + L F SL Sbjct: 143 VDVAELMADLIIFTASRCLLGDEVRQYLSEK-----NLGKLYHDIDDGISPLSFFYPSLP 197 Query: 246 RWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNA--ELSPDA 303 K K E + + +K + L + EL+ Sbjct: 198 APKRDKARKAVGEIFQELLDKRREEHKKHPERLLDESKMDVVDHLLTQKYKDGQELTDVH 257 Query: 304 IKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELP 363 + T+ TL + N V + +R+E S ++ Sbjct: 258 RIGILIAGLFAGQHTSSITSSWTLMNVISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMD 317 Query: 364 LLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERY 423 L A +KE LR+YP + + R+A + Y IP G ++ V GR + P+ + Sbjct: 318 YLEACMKEALRMYPPLIMIMRMARKPRECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVF 377 Query: 424 NPQRWLDIRGSGRNFYH--VPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDI 481 +P+R L R F + VPFG G +C+G A ++ ++ +L++ +E + + Sbjct: 378 DPER-LTERKEHEKFKYGAVPFGAGRHKCIGENFALLQVKSIISILLRYFDMEYIGKIPD 436 Query: 482 KMVYSFILRPSMF 494 S ++ PS Sbjct: 437 PSYTSLVVGPSPP 449 >5YLW-A nrPDB Length = 495 Score = 208 bits (530), Expect = 4e-54, Method: Composition-based stats. Identities = 94/425 (22%), Positives = 165/425 (38%), Gaps = 25/425 (5%) Query: 65 HLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDS-LHPHRMSLEPWVAYRQHR 123 H + + GP+ LG V V PE +++ + R + A H Sbjct: 49 HQVFAKLSKRYGPLMSIHLGSLYTVIVSSPEMAKEILHRHGQVFSGRTIAQAVHAC-DHD 107 Query: 124 GHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGS 183 G + EWR R ++ S +++ + R Q L V + + Sbjct: 108 KISMGFLPVAS-EWRDMRKICKEQMFSNQSMEAS----QGLRRQKLQQLLDHVQKCSDSG 162 Query: 184 LTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRS 243 +D++ + F T+ + LF S A++ F +E + F Sbjct: 163 RAVDIREAAFITTLNLMSATLFS---SQATEFDSKATMEFKEIIEGVATIVGVPNF--AD 217 Query: 244 LSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRP--------QQYTSIVAELLL 295 P + D F I+ E S+ + IV +++ Sbjct: 218 YFPILRPFDPQGVKRRADVFFGKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDIIQ 277 Query: 296 NAE--LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISE 353 E L ++L G DT + + EL NP+ L+ E + A Sbjct: 278 ANEFKLKTHHFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKI 337 Query: 354 HPQKATTELPLLRAALKETLRLYPVGL-FLERVASSDLVLQNYHIPAGTLVRVFLYSLGR 412 + A +LP L+A +KE +R++P G L R A SD + Y IP GT + + Y++GR Sbjct: 338 VDESAMPKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGR 397 Query: 413 NPALFPRPERYNPQRWLD--IRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKH 470 +P+++ PE ++P+R+LD I G+++ +PFG G R C G LA + + ++ + Sbjct: 398 DPSIWTDPETFDPERFLDNKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHN 457 Query: 471 LQVET 475 + Sbjct: 458 FDWKL 462 >6HQG-A nrPDB Length = 425 Score = 207 bits (527), Expect = 8e-54, Method: Composition-based stats. Identities = 64/350 (18%), Positives = 121/350 (34%), Gaps = 38/350 (10%) Query: 158 LPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPS 217 LPM A+ +K V + ++P I + + GE + V Sbjct: 99 LPMFIAMDPPKHDVQRKTVQPIVAPNHLAYLEPIIRERAGKILDDLPIGEEINWVDKVSI 158 Query: 218 SASLNFLHALEVMFKSTVQLMFMPRSLSR------WTSPKVWKEHFEAWDCIFQYGDNCI 271 + L L + + ++ +EH + Sbjct: 159 ELTTMTLATLFDFPWEDRRKLTFWSDVATSAPESGILGTTDPEEHENLRRQTLFECVDYF 218 Query: 272 QKIYQELAFSRPQQYTSIVAELLLNAE----LSPDAIKANSMELTAGSVDTTVFPLLMTL 327 +++ E + P+ + +L + E + N + L G DTT + ++ Sbjct: 219 MRLWNERVNAPPKP---DLISMLAHGESTKNMDRMEYLGNLILLIVGGNDTTRNTISGSV 275 Query: 328 FELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVAS 387 L +NP+ + LR+ L+ A + ET+R ++ R A Sbjct: 276 LALHQNPDQDRKLRE------------------NPGLIPAMVSETIRWQTPLAYMRRRAK 317 Query: 388 SDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGM 447 D L I G V ++ S R+ + RP Y +R R H+ FGFG+ Sbjct: 318 RDFELGGKTIREGDKVAMWYVSGNRDEEVIDRPNDYWIER-------PRVRQHLSFGFGV 370 Query: 448 RQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLL 497 +C+G RLAE ++ ++ +L + ++ SF+ P++ Sbjct: 371 HRCVGNRLAELQLKIIWEEILARFPRLEVVGPPRRVYSSFVKGYEELPVV 420 >2HI4-A nrPDB Length = 495 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 89/500 (17%), Positives = 170/500 (34%), Gaps = 47/500 (9%) Query: 32 PRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCV 91 PR ++ P G W L + ++ HL + + Q G + + +G V V Sbjct: 9 PRVPKGLKSPPEPWG--WPLLGHVLTLG--KNPHLALSRMSQRYGDVLQIRIGS-TPVLV 63 Query: 92 MLPEDV--EKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRL----RLN 145 + D + L + R L G +GP W R LN Sbjct: 64 LSRLDTIRQALVRQGDDFKGRPDLYTSTLITD--GQSLTFSTDSGPVWAARRRLAQNALN 121 Query: 146 PEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALF 205 ++ + ++ ++AL ++ + G D + F Sbjct: 122 TFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCF 181 Query: 206 GERL---------------GLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSP 250 G+ V + S L+F L + +Q W Sbjct: 182 GQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQ 241 Query: 251 KVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSME 310 K +EH++ +D + I + + P+ +++ + + I + Sbjct: 242 KTVQEHYQDFD---KNSVRDITGALFKHSKKGPRASGNLIPQ---------EKIVNLVND 289 Query: 311 LTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALK 370 + DT + +L L P +Q+ +++E +LP L A + Sbjct: 290 IFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFIL 349 Query: 371 ETLRLYPVGLF-LERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWL 429 ET R F + + D L ++IP V V + + +P L+ P + P+R+L Sbjct: 350 ETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFL 409 Query: 430 DIRGSGRNFY----HVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQ--EDIKM 483 G+ N + FG G R+C+G LA+ E+ L L +L+ L+ D+ Sbjct: 410 TADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTP 469 Query: 484 VYSFILRPSMFPLLTFRAIN 503 +Y ++ + + R + Sbjct: 470 IYGLTMKHARCEHVQARRFS 489 >2VE3-A nrPDB Length = 444 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 89/461 (19%), Positives = 168/461 (36%), Gaps = 41/461 (8%) Query: 38 FEAMPRRPGN---RWL-RLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVML 93 ++P PG+ WL L + + + Q+ GPIF+ L G ++ + Sbjct: 8 LNSLPIPPGDFGLPWLGETLNFLNDGDFGK------KRQQQFGPIFKTRLFGKNVIFISG 61 Query: 94 PEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNA 153 L + W + + G E +R ++ + P Sbjct: 62 ALANRFLFTKE----QETFQATWPLSTRILLGPNALATQMG-EIHRSRRKILYQAFLPRT 116 Query: 154 VQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVG 213 + +LP +D + Q ++ + + P + T + + GE++ Sbjct: 117 LDSYLPKMDGI----VQGYLEQWGKANE----VIWYPQLRRMTFDVAATLFMGEKVS--- 165 Query: 214 HSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQK 273 F ++ +F + L ++ + A + + I+ Sbjct: 166 -QNPQLFPWFETYIQGLFSLPIPLPNT-----------LFGKSQRARALLLAELEKIIKA 213 Query: 274 IYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARN 333 Q+ + A N LS +K + L +T L L ++ Sbjct: 214 RQQQPPSEEDALGILLAARDDNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQH 273 Query: 334 PNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQ 393 ++++ +RQE S E + ++P L L+E LRL P R D Q Sbjct: 274 SDIRERVRQEQNKLQLS-QELTAETLKKMPYLDQVLQEVLRLIPPVGGGFRELIQDCQFQ 332 Query: 394 NYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGR--NFYHVPFGFGMRQCL 451 +H P G LV + +P L+P PE+++P+R+ + F HVPFG G+R+CL Sbjct: 333 GFHFPKGWLVSYQISQTHADPDLYPDPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECL 392 Query: 452 GRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPS 492 G+ A EM L +++ L +++++V + RP Sbjct: 393 GKEFARLEMKLFATRLIQQFDWTLLPGQNLELVVTPSPRPK 433 >5FSA-A nrPDB Length = 490 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 74/439 (16%), Positives = 157/439 (35%), Gaps = 60/439 (13%) Query: 73 QELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGV-FL 131 Q+ G +F + L G M + P+ E + + AY+ G + Sbjct: 35 QKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLS-----DVSAEEAYKHLTTPVFGTGVI 89 Query: 132 LNGPEWR-FNRLRLNPEVLSPNAVQRFLPMV-DAVARDFSQALKKKVLQNARGSLTLDVQ 189 + P R + + L+ ++ +R++P + + + F + + +V Sbjct: 90 YDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVT--DESFKLKEKTHGVANVM 147 Query: 190 PSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTS 249 + TI ++ +LFG+ + + +F + K + F+ Sbjct: 148 KTQPEITIFTASRSLFGDEMRRI------FDRSFAQLYSDLDKGFTPINFV--------F 193 Query: 250 PKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQ--QYTSIVAELLLNA------ELSP 301 P + H+ D + K + L R ++ LL+++ +++ Sbjct: 194 PNLPLPHYWRRDAAQKKISATYMKEIK-LRRERGDIDPNRDLIDSLLIHSTYKDGVKMTD 252 Query: 302 DAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAA----ASISEHPQK 357 I + + G T+ L L P++Q + QE + +++ + Sbjct: 253 QEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYE 312 Query: 358 ATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQ--NYHIPAGTLVRVFLYSLGRNPA 415 +LP + +KETLR++ + R ++ L + NY +P G V V + Sbjct: 313 DLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSER 372 Query: 416 LFPRPERYNPQRWLDIRG---------------------SGRNFYHVPFGFGMRQCLGRR 454 F PE ++P RW G + ++PFG G +C+G + Sbjct: 373 YFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQ 432 Query: 455 LAEAEMLLLLHHVLKHLQV 473 A ++ +L + +L+ Sbjct: 433 FAYVQLGTILTTFVYNLRW 451 >6IQ5-A nrPDB Length = 463 Score = 202 bits (514), Expect = 3e-52, Method: Composition-based stats. Identities = 91/464 (19%), Positives = 159/464 (34%), Gaps = 42/464 (9%) Query: 62 EDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDV-EKLQQVDSLHPHRMSLEPWVAYR 120 + HL + + G +F+ LG +V + + + L Q S R + ++R Sbjct: 1 QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADR---PSFASFR 57 Query: 121 QHRGHKCGVFLLNGPEWRFNRLRLNPEVL-----SPNAVQRFLPMVDAVARDFSQALKKK 175 G + F W+ R + + P + Q V + AR+ L Sbjct: 58 VVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALL--- 114 Query: 176 VLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTV 235 V +A G+ LD +P + FG R L E Sbjct: 115 VRGSADGAF-LDPRPLTVVAVANVMSAVCFGCRYS----HDDPEFRELLSHNEEF--GRT 167 Query: 236 QLMFMPRSLSRWT--SPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFS-RPQQYTSIVAE 292 + W P + F ++ + + N I + S RP + + Sbjct: 168 VGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMD 227 Query: 293 LLL--------------NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQ 338 + A L + + A ++ S DT L L R P+VQ Sbjct: 228 AFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQT 287 Query: 339 ALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYP-VGLFLERVASSDLVLQNYHI 397 ++ E LP + A L E +R V + + +++ + YHI Sbjct: 288 RVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHI 347 Query: 398 PAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRG---SGRNFYHVPFGFGMRQCLGRR 454 P T+V V +S+ +P +P PE ++P R+LD G + F G R+C+G Sbjct: 348 PKDTVVFVNQWSVNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEE 407 Query: 455 LAEAEMLLLLHHVLKHLQVETLTQEDIKM--VYSFILRPSMFPL 496 L++ ++ L + + E KM Y ++P F + Sbjct: 408 LSKMQLFLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKV 451 >5H1Z-A nrPDB Length = 407 Score = 201 bits (512), Expect = 5e-52, Method: Composition-based stats. Identities = 65/394 (16%), Positives = 137/394 (34%), Gaps = 35/394 (8%) Query: 109 HRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLN-PEVLSPNAVQRFLPMVDAVARD 167 HR+ + Y +K + + + P+ + + + + N +PM A+ R Sbjct: 38 HRVEHSDFGPYWSVSSYKPIITVESLPDLYSSAGGITLADFIENNPTDVRMPMFIAMDRP 97 Query: 168 FSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHAL 227 ++ V S + + +I T E + + V + L L Sbjct: 98 KHTGQRRTVAPAFTPSEMVRMSDNIRMRTAEVLDSLEWNTPFDWVDTVSVELTTQMLAIL 157 Query: 228 EVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSR-PQQY 286 + + S W ++ E ++ C +Q L ++ + Sbjct: 158 FDFPWEERRKLTF---WSDWAGDIELVKNEELRLERLRHMYEC-GGYFQNLWNAKIGKPP 213 Query: 287 TSIVAELLLNA----ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQ 342 T + +++++ E+ N + L G DTT + + L P+ + L Sbjct: 214 TPDLISMMIHSDAMAEMDQMEFLGNLILLIVGGNDTTRNTMSAVAYGLDLFPDQRAKLEA 273 Query: 343 ESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTL 402 + ++ ++E +R + R A+ D L+ I AG Sbjct: 274 DP------------------SMIPNTVQEIIRWQTPLAHMRRTATVDSELEGQQIKAGDK 315 Query: 403 VRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLL 462 + ++ S R+ ++F +R R H+ FG G+ +C+G RLAE ++ + Sbjct: 316 LALWYISANRDESVFENADRIIVDR-------PNARRHLAFGHGIHRCVGARLAELQIAV 368 Query: 463 LLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPL 496 LL + K + E ++ F+ P+ Sbjct: 369 LLEEMAKRRMRVNVLGEPERVAACFVHGYRKLPV 402 >5OFQ-A nrPDB Length = 409 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 75/424 (17%), Positives = 141/424 (33%), Gaps = 45/424 (10%) Query: 92 MLPEDVEK------LQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEW------RF 139 M P+ V++ L + + L P+ Y R + + W Sbjct: 1 MNPKAVKRENRYANLIPMQEIKSVEQQLYPFDIYNSLRQEAPIRYDESRNCWDVFDYETV 60 Query: 140 NRLRLNPEVLS-PNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIE 198 + NP + S A++ + + L+ V + ++ I Sbjct: 61 KYILKNPSLFSSKRAMEERQESILMMDPPKHTKLRNLVNKAFTPRAIQHLEGHIEEIADY 120 Query: 199 ASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFE 258 + E+ +V + + L + L + E F Sbjct: 121 LLDEVSSKEKFDIVEDFAGPLPIIVIAELLGVPIQDRALFKKYSDDLVSGAENNSDEAFA 180 Query: 259 AWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAE-----LSPDAIKANSMELTA 313 G +Q ++E+ R Q + LLL AE L+ + + + L Sbjct: 181 KMMQKRNEGVIFLQGYFKEIIAERQQNKQEDLISLLLEAEIDGEHLTEEEVLGFCILLLV 240 Query: 314 GSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETL 373 +TT + + + + +VQ +R++ L+ ++ETL Sbjct: 241 AGNETTTNLITNGVRYMTEDVDVQNEVRRDI------------------SLVPNLVEETL 282 Query: 374 RLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRG 433 R YP + R+A+ D+ L I G V + S R+ A F P+ + R Sbjct: 283 RYYPPIQAIGRIAAEDVELGECKIKRGQQVISWAASANRDSAKFEWPDTFVVHR------ 336 Query: 434 SGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYS-FILRPS 492 + HV FGFG+ CLG LA E + +L+ + + +K + S F+ Sbjct: 337 --KTNPHVSFGFGIHFCLGAPLARMEGKIAFTKLLEKGGFSKVQNQSLKPIDSPFVFGVK 394 Query: 493 MFPL 496 + + Sbjct: 395 KYEI 398 >1UED-A nrPDB Length = 406 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 68/384 (17%), Positives = 129/384 (33%), Gaps = 42/384 (10%) Query: 120 RQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQN 179 Q G++ +L E R + + +F+ + L+K + Sbjct: 56 WQAHGYEVVRRILGDHEHFTTRPQFTQSKSGAHVEAQFVGQISTYDPPEHTRLRKMLTPE 115 Query: 180 ARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMF 239 +E + +L +RL L+ SA L L A V + +L+ Sbjct: 116 FTVRRI---------RRMEPAIQSLIDDRLDLLEAEGPSADLQGLFADPVGAHALCELLG 166 Query: 240 MPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQE--LAFSRPQQYTSIVAELLLN- 296 +PR R ++ + + + D+ Y + LA R ++ ++ + Sbjct: 167 IPRDDQREFVRRIRRNADLSRGLKARAADSAAFNRYLDNLLARQRADPDDGLLGMIVRDH 226 Query: 297 -AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHP 355 ++ + +K L G V+T + + L NP + L + A Sbjct: 227 GDNVTDEELKGLCTALILGGVETVAGMIGFGVLALLDNPGQIELLFESPEKA-------- 278 Query: 356 QKATTELPLLRAALKETLRLYPVGLFL-ERVASSDLVLQNYHIPAGTLVRVFLYSLGRNP 414 + E +R R+A D+V+ I AG V + R+ Sbjct: 279 ----------ERVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDE 328 Query: 415 ALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVE 474 AL P P+ + R V FG G+ C+G LA + + + + + Sbjct: 329 ALTPDPDVLDANRAAVSD--------VGFGHGIHYCVGAALARSMLRMAYQTLWRRFPGL 380 Query: 475 TLTQ--EDIKMVYSFILRPSMFPL 496 L E++K +F+ P P+ Sbjct: 381 RLAVPIEEVKYRSAFVDCPDQVPV 404 >3JUS-A nrPDB Length = 461 Score = 195 bits (495), Expect = 5e-50, Method: Composition-based stats. Identities = 74/435 (17%), Positives = 154/435 (35%), Gaps = 40/435 (9%) Query: 72 FQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFL 131 +++ GP+F + + G ++ + L + + + + K + Sbjct: 41 YEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDV--YSRLTTPVFGKGVAYD 98 Query: 132 LNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPS 191 + P + + L L+ ++ + +++ +++ ++ + +N V + Sbjct: 99 VPNPVFLEQKKML-KSGLNIAHFKQHVSIIEKETKEYFESWGESGEKN--------VFEA 149 Query: 192 IFHYTIEASNLALFGERL-GLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSP 250 + I ++ L G+ + + + + +P L + Sbjct: 150 LSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAW------LLPGWLPLPSFR 203 Query: 251 KVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAE-LSPDAIKANSM 309 + + H E D + IQK Q +++ + L+ D + + Sbjct: 204 RRDRAHREIKDIFY----KAIQKRRQS-QEKIDDILQTLLDATYKDGRPLTDDEVAGMLI 258 Query: 310 ELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAA-SISEHPQKATTELPLLRAA 368 L T+ F LAR+ +Q+ E ++ +L LL Sbjct: 259 GLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRC 318 Query: 369 LKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRW 428 +KETLRL P + + R+A + + Y IP G V V R + +NP R+ Sbjct: 319 IKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRY 378 Query: 429 L-DIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSF 487 L D SG F +VPFG G +C+G A ++ + +L+ +Y F Sbjct: 379 LQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLR--------------LYEF 424 Query: 488 ILRPSMFPLLTFRAI 502 L FP + + + Sbjct: 425 DLIDGYFPTVNYTTM 439 >4RM4-A nrPDB Length = 396 Score = 191 bits (486), Expect = 5e-49, Method: Composition-based stats. Identities = 63/348 (18%), Positives = 122/348 (35%), Gaps = 40/348 (11%) Query: 151 PNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLG 210 P + + ++ V + + +P I T E Sbjct: 71 PQQTSSIGNSIINMDPPKHTKIRSVVNKAFTPRVMKQWEPRIQEITDELIQKFQGRSEFD 130 Query: 211 LVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNC 270 LV + + L + + ++ L ++PK E EA + D C Sbjct: 131 LVHDFSYPLPVIVISELLGVPSAHMEQFKAWSDLL-VSTPKDKSE--EAEKAFLEERDKC 187 Query: 271 IQKI---YQELAFSRPQQYTSIVAELLLNAE-----LSPDAIKANSMELTAGSVDTTVFP 322 +++ + + + + + +L+ AE LS + + L +TT Sbjct: 188 EEELAAFFAGIIEEKRNKPEQDIISILVEAEETGEKLSGEELIPFCTLLLVAGNETTTNL 247 Query: 323 LLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382 + ++ + P V + LR L+ A++E LR L Sbjct: 248 ISNAMYSILETPGVYEELRS------------------HPELMPQAVEEALRFRAPAPVL 289 Query: 383 ERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVP 442 R+A D + + I G +V F+ S R+ A F RP ++ +R + H+ Sbjct: 290 RRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRRHPN--------PHIA 341 Query: 443 FGFGMRQCLGRRLAEAEMLLLLHHVLK---HLQVETLTQEDIKMVYSF 487 FG G+ CLG LA E + L ++ H++ ++T + ++Y Sbjct: 342 FGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGL 389 >3EJB-B nrPDB Length = 404 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 59/343 (17%), Positives = 118/343 (34%), Gaps = 39/343 (11%) Query: 166 RDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLH 225 + + L+ T QP I + +++ ++ + + Sbjct: 85 QPDHRRLRTLASGAFTPRTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIA 144 Query: 226 ALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCI---QKIYQELAFSR 282 + + + + L W + + F G+ ++EL R Sbjct: 145 NIIGVPEEDRE------QLKEWAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKR 198 Query: 283 PQQYTSIVAELLLNA----ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQ 338 + + +LL +L+ + + + L +TTV + ++ L ++P Sbjct: 199 KRHPQQDMISMLLKGREKDKLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLL 258 Query: 339 ALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIP 398 LR+ L+ A++E LR RVAS D+ + I Sbjct: 259 KLRENPD------------------LIGTAVEECLRYESPTQMTARVASEDIDICGVTIR 300 Query: 399 AGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEA 458 G V + L + R+P++F P+ ++ R + H+ FG G CLG LA Sbjct: 301 QGEQVYLLLGAANRDPSIFTNPDVFDITRSPN--------PHLSFGHGHHVCLGSSLARL 352 Query: 459 EMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRA 501 E + ++ +L+ + L + + F R +TF A Sbjct: 353 EAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPVTFEA 395 >3L4D-A nrPDB Length = 453 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 74/435 (17%), Positives = 137/435 (31%), Gaps = 38/435 (8%) Query: 68 VHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHR--GH 125 + + ++ G IF ++ G + V Q P L P Y Sbjct: 29 MLKAKKKYGGIFTMNICGNRITVVGDVH-----QHSKFFTPRNEILSPREVYSFMVPVFG 83 Query: 126 KCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLT 185 + + P R L E L+ Q F P + R F +K ++ Sbjct: 84 EGVAYAAPYPRMREQ-LNFLAEELTVAKFQNFAPSIQHEVRKF---MKANWNKDEGE--- 136 Query: 186 LDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLS 245 +++ I + LFGE L + F L M + Sbjct: 137 INILDDCSAMIINTACQCLFGEDL-----RKRLDARQFAQLLAKMESCLIPAAVFLP--- 188 Query: 246 RWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFS--RPQQYTSIVAELL-----LNAE 298 W + + D + D + I + + ++A LL Sbjct: 189 -WILKLPLPQSYRCRDARAELQDILSEIIIAREKEEAQKDTNTSDLLAGLLGAVYRDGTR 247 Query: 299 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELA--RNPNVQQALRQESLAAAASISEHPQ 356 +S + + T+ +L L RN L QE A ++ Sbjct: 248 MSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLHQEIDEFPAQLNY--D 305 Query: 357 KATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPAL 416 E+P +E++R P + L R + + Y +P G ++ ++ Sbjct: 306 NVMEEMPFAEQCARESIRRDPPLVMLMRKVLKPVQVGKYVVPEGDIIACSPLLSHQDEEA 365 Query: 417 FPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETL 476 FP P +NP+R + + FG G+ +C+G + ++ +L VL+ E L Sbjct: 366 FPNPREWNPERNMKLVDGA----FCGFGAGVHKCIGEKFGLLQVKTVLATVLRDYDFELL 421 Query: 477 TQEDIKMVYSFILRP 491 ++ ++ P Sbjct: 422 GPLPEPNYHTMVVGP 436 >4KPA-A nrPDB Length = 494 Score = 188 bits (477), Expect = 5e-48, Method: Composition-based stats. Identities = 90/467 (19%), Positives = 174/467 (37%), Gaps = 32/467 (6%) Query: 39 EAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVE 98 + MP+ L+ L + + + + ELG IF+++ G + ++ Sbjct: 27 KEMPQPKTFGELKNLPLL---NTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIK 83 Query: 99 KLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFL 158 + +S +S R G + W+ L P S A++ + Sbjct: 84 EACD-ESRFDKNLSQALKFV-RDFAGDGLFTSWTHEKNWKKAHNILLPS-FSQQAMKGYH 140 Query: 159 PMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERL-GLVGHSPS 217 M+ +A Q ++ NA ++V + T++ L F R P Sbjct: 141 AMMVDIAVQLVQKWER---LNADEH--IEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPH 195 Query: 218 SASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQE 277 + + AL+ + P + + + ++E + + + + KI + Sbjct: 196 PFITSMVRALDEAMNKLQRAN--PDDPAYDENKRQFQEDIKVMN-------DLVDKIIAD 246 Query: 278 LAFSRPQQYTSIVAELLLNAE------LSPDAIKANSMELTAGSVDTTVFPLLMTLFELA 331 S +Q ++ +L + L + I+ + +TT L L+ L Sbjct: 247 RKAS-GEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLV 305 Query: 332 RNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLV 391 +NP+V Q +E+ K +L + L E LRL+P A D V Sbjct: 306 KNPHVLQKAAEEAARVLVD-PVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTV 364 Query: 392 LQN-YHIPAGTLVRVFLYSLGRNPALF-PRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQ 449 L Y + G + V + L R+ ++ E + P+R+ + ++ PFG G R Sbjct: 365 LGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQH-AFKPFGNGQRA 423 Query: 450 CLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPL 496 C+G++ A E L+L +LKH E T ++ + + L+P F + Sbjct: 424 CIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVV 470 >3EL3-A nrPDB Length = 467 Score = 188 bits (476), Expect = 6e-48, Method: Composition-based stats. Identities = 92/474 (19%), Positives = 161/474 (33%), Gaps = 30/474 (6%) Query: 26 TRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGG 85 TRA P P P G L WR L ++ G + R LG Sbjct: 10 TRAPAAP--GAPELREPPVAGGGVPLLGHGWR---LARDPLAFMSQLRDHGDVVRIKLGP 64 Query: 86 AGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLN 145 + V PE L H ++ W + G + GV NGP R R + Sbjct: 65 KTVYAVTNPELTGALALNPDYH---IAGPLWESLEGLLGKE-GVATANGPLHRRQRRTIQ 120 Query: 146 PEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALF 205 P +A+ + P+++ A ++ + T+D F + + L Sbjct: 121 P-AFRLDAIPAYGPIMEEEAHALTER--------WQPGKTVDATSESFRVAVRVAARCL- 170 Query: 206 GERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQ 265 L G + AL +F+ + M +P + +A + Sbjct: 171 -----LRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHL 225 Query: 266 YGDNCIQKIYQELAFSRPQQYTSIVAELLLN--AELSPDAIKANSMELTAGSVDTTVFPL 323 D I + + +P + + E + + I + + +T + Sbjct: 226 LVDEIIAERRA--SGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTI 283 Query: 324 LMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 383 + L LA +P +R E A + +L + E +RL P L Sbjct: 284 MWLLQALADHPEHADRIRDEVEAVTGG-RPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLT 342 Query: 384 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHV-P 442 R A ++ L Y IPAG + Y++ R+P + ++P RWL R + Y + P Sbjct: 343 RRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKP 402 Query: 443 FGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPL 496 F G R+C + A++ L+ + + E + + + LRP + Sbjct: 403 FSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLV 456 >5FYF-A nrPDB Length = 470 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 67/427 (15%), Positives = 134/427 (31%), Gaps = 55/427 (12%) Query: 99 KLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLN----GPEWRFNRL------------ 142 L+ +D +P W AY + + V GP W R Sbjct: 64 ALEDIDVSNPFLYRQGQWRAYFKRLRDEAPVHYQKNSPFGPFWSVTRFEDILFVDKSHDL 123 Query: 143 -RLNPEVLSPNAVQRF-LPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEAS 200 P+++ + + + M A+ + V +++ I T + Sbjct: 124 FSAEPQIILGDPPEGLSVEMFIAMDPPKHDVQRSSVQGVVAPKNLKEMEGLIRSRTGDVL 183 Query: 201 NLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAW 260 + + V + L L + + E F Sbjct: 184 DSLPTDKPFNWVPAVSKELTGRMLATLLDFPYEERHKLVEWSDRMAGAASATGGE-FADE 242 Query: 261 DCIFQYGDNCIQKIY-----QELAFSRPQQYTSIVAELLLNAELSPD------AIKANSM 309 + +F + + +E + ++ + LL + + + D N Sbjct: 243 NAMFDDAADMARSFSRLWRDKEARRAAGEEPGFDLISLLQSNKETKDLINRPMEFIGNLT 302 Query: 310 ELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAAL 369 L G DTT + L + P + L + L+ + Sbjct: 303 LLIVGGNDTTRNSMSGGLVAMNEFPREFEKL------------------KAKPELIPNMV 344 Query: 370 KETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWL 429 E +R ++ R+A D+ L I G V ++ S R+ F P+++ R Sbjct: 345 SEIIRWQTPLAYMRRIAKQDVELGGQTIKKGDRVVMWYASGNRDERKFDNPDQFIIDR-- 402 Query: 430 DIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFIL 489 H+ FG+G+ +C+G RLAE ++ +L +LK + +E ++ +F+ Sbjct: 403 -----KDARNHMSFGYGVHRCMGNRLAELQLRILWEEILKRFDNIEVVEEPERVQSNFVR 457 Query: 490 RPSMFPL 496 S + Sbjct: 458 GYSRLMV 464 >2WX2-A nrPDB Length = 473 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 70/424 (16%), Positives = 142/424 (33%), Gaps = 36/424 (8%) Query: 78 IFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHR--GHKCGVFLLNGP 135 +F +GG + V P + P L P Y + + P Sbjct: 53 VFTISIGGQRVTIVGDPHE-----HSRFFSPRNEILSPREVYTIMTPVFGEGVAYAAPYP 107 Query: 136 EWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHY 195 R L E L+ Q F+P + R F + + ++ +++ Sbjct: 108 RMREQ-LNFLAEELTIAKFQNFVPAIQHEVRKF---MAENWKEDE---GVINLLEDCGAM 160 Query: 196 TIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKE 255 I + LFGE L + + +F L M S + L R P Sbjct: 161 IINTACQCLFGEDLRKRLN-----ARHFAQLLSKMESSLIPAAVFMPWLLRL--PLPQSA 213 Query: 256 HFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELL-----LNAELSPDAIKANSME 310 Q I ++ S+ + ++ LL +S + + Sbjct: 214 RCREARAELQKILGEIIVAREKEEASKDNNTSDLLGGLLKAVYRDGTRMSLHEVCGMIVA 273 Query: 311 LTAGSVDTTVFPLLMTLFELAR--NPNVQQALRQESLAAAASISEHPQKATTELPLLRAA 368 T+ ++ L N L +E A ++ E+P Sbjct: 274 AMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEFPAQLNY--DNVMDEMPFAERC 331 Query: 369 LKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRW 428 ++E++R P L + R+ +++ + +Y +P G ++ + FP P ++P+R Sbjct: 332 VRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERD 391 Query: 429 LDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQE-DIKMVYSF 487 + G+ + FG G+ +C+G++ A ++ +L + + L E ++ Sbjct: 392 EKVDGA-----FIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTM 446 Query: 488 ILRP 491 ++ P Sbjct: 447 VVGP 450 >5VWS-A nrPDB Length = 393 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 76/421 (18%), Positives = 138/421 (32%), Gaps = 40/421 (9%) Query: 81 YDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFN 140 +L G + L+ + + HP + + + Y R L + + + Sbjct: 5 MELPGQPSLTDGGAALFAWLRTMRNEHP--VWRDQFGIYHVFRYDDVRQILGDYQTFSSD 62 Query: 141 RLRLNPEVLSPNAVQRFLPM-VDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEA 199 R RL P Q F + + + ++ + ++P I Sbjct: 63 RTRLMPTA------QGFGKGGITMIDPPEHRHQRRLITHAFTPQSISAMEPRIRQIADHL 116 Query: 200 SNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEA 259 + G LV H + + L + L + + + A Sbjct: 117 LDELP-GPEFDLVEHFAYPLPVIVIAELLGVPPGDRHLFRTWSDRLMSLQVENYADPELA 175 Query: 260 W---DCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSV 316 + + D + R T +V + L + + + L Sbjct: 176 RTVAAAMTEMNDYLREHCRSRRTHPRDDLLTRLVQAEVEGKRLDLEEVVNTASLLLLAGH 235 Query: 317 DTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLY 376 TT + T+ L +P ++A+R + L+ AAL+E+LRL Sbjct: 236 LTTTVLIGNTMLCLWDHPEAEKAVRADP------------------SLIPAALEESLRLR 277 Query: 377 PVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGR 436 L RV + D+ + IPA V ++ S + FP PER++ R + Sbjct: 278 SPFLQAGRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPERFDLHR--------Q 329 Query: 437 NFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL-QVETLTQEDIKMVYSFILRPSMFP 495 H+ FG G+ CLG +L E + L +L ++ +E I S I S P Sbjct: 330 TTGHIAFGHGVHFCLGAQLGRLEGRIALERLLGRFTEIHPWPREGISFYQSAIFGASRMP 389 Query: 496 L 496 + Sbjct: 390 V 390 >5LIE-A nrPDB Length = 414 Score = 185 bits (469), Expect = 4e-47, Method: Composition-based stats. Identities = 66/360 (18%), Positives = 118/360 (32%), Gaps = 42/360 (11%) Query: 134 GPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIF 193 G + RF L ++ + + + +++ V + V+ + Sbjct: 75 GGQRRFGGTVLQDLPVAGQVL-------NMMDDPRHTRIRRLVSSGLTPRMIRRVEDDLR 127 Query: 194 HYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKST-------VQLMFMPRSLSR 246 + G V + + + L + ++ V+ F R R Sbjct: 128 RRARGLLDGVEPGAPFDFVVEIAAELPMQMICILLGVPETDRHWLFEAVEPGFDFRGSRR 187 Query: 247 WTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKA 306 T P++ E A ++ Y I E A + + LS + Sbjct: 188 ATMPRLNVED--AGSRLYTYALELIAGKRAEPADDMLSVVANATIDDPDAPALSDAELYL 245 Query: 307 NSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLR 366 L + +TT + L LA NP+ Q LR + LL Sbjct: 246 FFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSD------------------FELLP 287 Query: 367 AALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQ 426 A++E +R R AS + L I AG V V+ S R+P++F R + ++ Sbjct: 288 TAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRADEFDIT 347 Query: 427 RWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYS 486 R + H+ FG G+ CLG LA E+ +L +L + + + Sbjct: 348 R--------KPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFGSVRVVEPAEWTRSN 399 >6CR2-A nrPDB Length = 477 Score = 185 bits (469), Expect = 5e-47, Method: Composition-based stats. Identities = 73/437 (16%), Positives = 145/437 (33%), Gaps = 55/437 (12%) Query: 74 ELGPIFR-YDLGGAGMVCVML-PEDVEKLQQVDSLHPHRMSLEPWV-AYRQHRGHKCGVF 130 + G IF LG V + D ++ + + + +H + C Sbjct: 36 KYGDIFTFILLGKKTTVYLGTKGNDFILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNA 95 Query: 131 LLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARG-SLTLDVQ 189 L + + L+ +A++ ++P++ F K +G DV Sbjct: 96 KL------MEQKKFVKYGLTSDALRSYVPLITDEVESFV-----KNSPAFQGHKGVFDVC 144 Query: 190 PSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTS 249 +I TI ++ +L G+ S F + + FM Sbjct: 145 KTIAEITIYTASRSLQGKE------VRSKFDSTFAELYHNLDMGFAPINFML-------- 190 Query: 250 PKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTS-----IVAELLLNAE-LSPDA 303 P H D + +I + + ++ + +++ + N + + Sbjct: 191 PWAPLPHNRKRDAAQRKLTETYMEIIKARRQAGSKKDSEDMVWNLMSCVYKNGTPVPDEE 250 Query: 304 IKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAAS-ISEHPQKATTEL 362 I + L ++ + LA P++ + L QE + S + +L Sbjct: 251 IAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVLGSDLPPLTYDNLQKL 310 Query: 363 PLLRAALKETLRLYPVGLFLERVASSDLVLQN--YHIPAGTLVRVFLYSLGRNPALFPRP 420 L +KETLRL+ + R + + + Y IP V R+ FP P Sbjct: 311 DLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSHNVLSSPGVTARSEEHFPNP 370 Query: 421 ERYNPQRWLD-----------------IRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLL 463 +NP RW + + G N ++PFG G +C+G + A ++ + Sbjct: 371 LEWNPHRWDENIAASAEDDEKVDYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYLQLGTI 430 Query: 464 LHHVLKHLQVETLTQED 480 +++ + L D Sbjct: 431 TAVLVRLFRFRNLPGVD 447 >5L94-A nrPDB Length = 410 Score = 184 bits (468), Expect = 6e-47, Method: Composition-based stats. Identities = 56/336 (16%), Positives = 112/336 (33%), Gaps = 38/336 (11%) Query: 161 VDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSAS 220 + + ++ V + +P I T E E + +V H Sbjct: 84 LINIDPPKHAEMRALVNKAFTPKAMKAWEPKIARITNELLQEVEHLEDIDIVEHLSYPLP 143 Query: 221 LNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF 280 + + + + + + +E E ++ ++ + + Sbjct: 144 VMVIADILGVPIEDQRQFKDWSDIIVAGPSNNERETLEKLQQEKMKANDELETYFYRIIE 203 Query: 281 SRPQQYTSIVAELLLNAE-----LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPN 335 + + + +LL A+ L+ + I S+ L +TT + T++ L + Sbjct: 204 EKRTRPGDDIISVLLQAKEEGKQLTDEEIVGFSILLLIAGNETTTNLISNTIYCLMEDKA 263 Query: 336 VQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNY 395 + L++E LL + ++E LR L R+ D+ L Sbjct: 264 SFERLKREKE------------------LLPSGIEEVLRYRSPVQALHRIVKEDVTLAGK 305 Query: 396 HIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRL 455 + AG V ++ S R+ F PE + R + H+ FG G+ CLG L Sbjct: 306 KLKAGEHVVPWMGSAHRDAEYFEDPEVFKIDR--------KPNVHMAFGRGIHFCLGAPL 357 Query: 456 AEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRP 491 A E ++L ++ + SF L+P Sbjct: 358 ARIEAKIMLAELIDRYP-------QMDWSPSFELKP 386 >2W0A-A nrPDB Length = 455 Score = 184 bits (466), Expect = 1e-46, Method: Composition-based stats. Identities = 75/415 (18%), Positives = 135/415 (32%), Gaps = 22/415 (5%) Query: 68 VHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKC 127 + + ELG + + L G +V + E + + P+ G Sbjct: 30 MQRVRDELGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPF--MTPIFGEA- 86 Query: 128 GVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLD 187 V PE + L+ L ++ ++ D + + + +D Sbjct: 87 -VVFDASPE--RRKEMLHNAALRGEQMKGHAATIE----DQVRRMIADWGEAGE----ID 135 Query: 188 VQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRW 247 + TI S+ L G++ F + + T L ++ L Sbjct: 136 LLDFFAELTIYTSSACLIGKKFR------DQLDGRFAKLYHELERGTDPLAYVDPYLPIE 189 Query: 248 TSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKAN 307 + + + + + I + + V S D I Sbjct: 190 SFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEITGM 249 Query: 308 SMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRA 367 + + T+ TL EL R+ + A+ E A ++P L Sbjct: 250 FISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQLEN 309 Query: 368 ALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQR 427 LKETLRL+P + L RVA + +Q + I G LV R P FP P + P R Sbjct: 310 VLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFVPAR 369 Query: 428 WLDIRGSG--RNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED 480 + R + +PFG G +C+G A ++ + +L+ + E + Sbjct: 370 YEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQPPE 424 >6HQD-A nrPDB Length = 420 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 71/428 (16%), Positives = 130/428 (30%), Gaps = 58/428 (13%) Query: 99 KLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLN----GPEWRFNRLR------LNPEV 148 L+ +D P + Y + + V GP W + N +V Sbjct: 17 ALEDIDVSKPELFERDGLHPYFERLRREDPVHYCKASEYGPYWSITKFSDIVAIDTNHKV 76 Query: 149 LSPNAVQR----------------FLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSI 192 S + +LP + + V L + +I Sbjct: 77 FSSDHTNGSFVLDDTTLNAVDGGIYLPNFLGMDPPKHDVHRMVVSPIVAPQNLLRFEATI 136 Query: 193 FHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKV 252 T + GE V + L L + + S + + Sbjct: 137 RERTKRVLSELPIGEEFNWVDRVSIELTTMMLATLLDFPFDDRRKLT---RWSDIITTRP 193 Query: 253 WKEHFEAWDCIFQYGDNC---IQKIYQELAFSRPQQYT-SIVAELLLNAELSPDAIKANS 308 ++W+ C Q++Y E P+ S++A +L+P Sbjct: 194 GYGLVDSWEQRESELMECLAYFQRLYAERQAMPPKPDLISMLAHSPEMQDLTPTDFLGTL 253 Query: 309 MELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAA 368 L G DTT + + P +R LL + Sbjct: 254 ALLIVGGNDTTRSSMSGSAMACHLYPQEFDKVR------------------NNRALLASV 295 Query: 369 LKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRW 428 + E +R + R A D+ + I G V ++ S R+ + RP + R Sbjct: 296 IPEVVRWQTPIAHMRRTALEDVEFRGKQIRKGDKVVMWYLSGNRDDEVIDRPMDFIADR- 354 Query: 429 LDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFI 488 R +H+ FGFG+ +CLG RLAE ++ +L + + + E +++ + + Sbjct: 355 ------PRARHHLSFGFGIHRCLGNRLAELQLKILWEEMCERYSRIEVCGEPVRVPSNLV 408 Query: 489 LRPSMFPL 496 P+ Sbjct: 409 HGYIDIPV 416 >2XKR-A nrPDB Length = 398 Score = 183 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 70/345 (20%), Positives = 122/345 (35%), Gaps = 31/345 (8%) Query: 158 LPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPS 217 LPM+ + +K V D + SI + V + Sbjct: 72 LPMMIDMDDPAHLLRRKLVNAGFTRKRVKDKEASIAALCDTLIDAVCERGECDFVRDLAA 131 Query: 218 SASLNFL-HALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFE-AWDCIFQYGDNCIQKIY 275 + + L V + + L + S V +E F+ D Y D I Sbjct: 132 PLPMAVIGDMLGVRPEQRDMFLRWSDDLVTFLSSHVSQEDFQITMDAFAAYNDFTRATIA 191 Query: 276 QELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPN 335 A + +V+ + LS D + ++ + G +TT L +L RN + Sbjct: 192 ARRADPTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETTRHTLSGGTEQLLRNRD 251 Query: 336 VQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNY 395 L+++ LL A++E LR + RV ++D Sbjct: 252 QWDLLQRDP------------------SLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGT 293 Query: 396 HIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRL 455 + AG + + S + A+F PE+++ QR + H+ FGFG CLG +L Sbjct: 294 ALCAGEKMMLLFESANFDEAVFCEPEKFDVQRNPN--------SHLAFGFGTHFCLGNQL 345 Query: 456 AEAEMLLLLHHVLKHLQVETLTQEDIKMVY---SFILRPSMFPLL 497 A E+ L+ VL+ L L +D + +F+ P++ Sbjct: 346 ARLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVV 390 >3S79-A nrPDB Length = 503 Score = 181 bits (459), Expect = 6e-46, Method: Composition-based stats. Identities = 81/431 (18%), Positives = 160/431 (37%), Gaps = 34/431 (7%) Query: 71 TFQELGPIFRYDLGGAGMVCVMLPEDVEKLQ---QVDSLHPHRMSLEPWVAYRQHRGHKC 127 + G R + G + + + + S ++ L+ H+ Sbjct: 77 YNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQC------IGMHEK 130 Query: 128 GVFLLNGPE-WRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTL 186 G+ N PE W+ R + LS + R + + + L++ ++ + Sbjct: 131 GIIFNNNPELWKTTRPFFM-KALSGPGLVRMVTVCAESLKTHLDRLEEVTNESG----YV 185 Query: 187 DVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSR 246 DV + ++ SN P S + ++ F + L+ P + Sbjct: 186 DVLTLLRRVMLDTSNTLFL--------RIPLDES-AIVVKIQGYFDAWQALLIKPDIFFK 236 Query: 247 --WTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAI 304 W K K + D I ++I E + + + +L+ + + Sbjct: 237 ISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENV 296 Query: 305 KANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPL 364 +E+ + DT L LF +A++PNV++A+ +E + +L + Sbjct: 297 NQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE-RDIKIDDIQKLKV 355 Query: 365 LRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYN 424 + + E++R PV + R A D V+ Y + GT + + + + R FP+P + Sbjct: 356 MENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFT 414 Query: 425 PQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQ---EDI 481 + + + Y PFGFG R C G+ +A M +L +L+ V+TL E I Sbjct: 415 LENFA---KNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESI 471 Query: 482 KMVYSFILRPS 492 + ++ L P Sbjct: 472 QKIHDLSLHPD 482 >4TRI-A nrPDB Length = 407 Score = 181 bits (458), Expect = 8e-46, Method: Composition-based stats. Identities = 64/344 (18%), Positives = 118/344 (34%), Gaps = 30/344 (8%) Query: 158 LPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPS 217 +P + + +K V +D SI + V + Sbjct: 75 MPYMIDMDDPQHLLRRKLVNAGFTRKRVMDKVDSIGRLCDTLIDAVCERGECDFVRDIAA 134 Query: 218 SASLNFL-HALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEA-WDCIFQYGDNCIQKIY 275 + + L V+ L+ L S V + + D Y + I Sbjct: 135 PLPMAVIGDMLGVLPTERDMLLKWSDDLVCGLSSHVDEAAIQKLMDTFAAYTEFTKDVIT 194 Query: 276 QELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPN 335 + A ++ +V + +S D I ++ + G +TT L +L R+ + Sbjct: 195 KRRAEPTDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHRD 254 Query: 336 VQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNY 395 AL ++ LL A++E LR + R ++D V Sbjct: 255 QWDAL------------------VADVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGT 296 Query: 396 HIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRL 455 + AG + + S + ++F P+ + R + HV FGFG CLG +L Sbjct: 297 ELRAGEKIMLMFESANFDESVFGDPDNFRIDRNPN--------SHVAFGFGTHFCLGNQL 348 Query: 456 AEAEMLLLLHHVLKHLQVETLTQE-DIKMVY-SFILRPSMFPLL 497 A E+ L+ VL+ L L + + + +F+ P P++ Sbjct: 349 ARLELRLMTERVLRRLPDLRLADDAPVPLRPANFVSGPESMPVV 392 >2WM5-A nrPDB Length = 435 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 59/376 (15%), Positives = 125/376 (33%), Gaps = 67/376 (17%) Query: 144 LNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 203 + +P + F M+ + Q L+ V + + ++ ++ + Sbjct: 101 ITINDQTPELAEYFGSMIV-LDDPRHQRLRSIVSRAFTPKVVARIEAAVRDRAHRLVSSM 159 Query: 204 LFG---ERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAW 260 + + LV L + +M +P++ + F Sbjct: 160 IANNPDRQADLVSELAGPLPLQII----------CDMMGIPKADHQRI--------FHWT 201 Query: 261 DCIFQYGDNCIQKIYQE--------------LAFSRPQQYTSIVAELLLNAELSPD---- 302 + I +GD + + E LA R + + L+ AE+ + Sbjct: 202 NVILGFGDPDLATDFDEFMQVSADIGAYATALAEDRRVNHHDDLTSSLVEAEVDGERLSS 261 Query: 303 -AIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTE 361 I + + L +TT + + L+R P + + Sbjct: 262 REIASFFILLVVAGNETTRNAITHGVLALSRYPEQRDR-----------------WWSDF 304 Query: 362 LPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPE 421 L A++E +R +++ R + D+ L+ + AG V ++ S R+ + F P Sbjct: 305 DGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPW 364 Query: 422 RYNPQRWLDIRGSGRNFYHVPF-GFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED 480 ++ R + H+ F G G CLG LA E+ + + + + T+E Sbjct: 365 TFDLARNPN--------PHLGFGGGGAHFCLGANLARREIRVAFDELRRQMPDVVATEEP 416 Query: 481 IKMVYSFILRPSMFPL 496 +++ FI P+ Sbjct: 417 ARLLSQFIHGIKTLPV 432 >1CPT-A nrPDB Length = 428 Score = 178 bits (450), Expect = 6e-45, Method: Composition-based stats. Identities = 58/350 (16%), Positives = 114/350 (32%), Gaps = 42/350 (12%) Query: 161 VDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLAL-FGERLGLVGHSPSSA 219 + ++ A + L + + ++ +I + L F + Sbjct: 102 LTSMDPPTHTAYRGLTLNWFQPASIRKLEENIRRIAQASVQRLLDFDGECDFMTDCALYY 161 Query: 220 SLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEH-----FEAWDCIFQYGDNCIQKI 274 L+ + + + LM + + E ++ D + I Sbjct: 162 PLHVVMTALGVPEDDEPLM--LKLTQDFFGVHEPDEQAVAAPRQSADEAARRFHETIATF 219 Query: 275 YQEL---AFSRPQQYTSIVAELLLNAELS-----PDAIKANSMELTAGSVDTTVFPLLMT 326 Y R V LL N++L I A + + DTT Sbjct: 220 YDYFNGFTVDRRSCPKDDVMSLLANSKLDGNYIDDKYINAYYVAIATAGHDTTSSSSGGA 279 Query: 327 LFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVA 386 + L+RNP A ++ L+ + E +R R A Sbjct: 280 IIGLSRNPEQLAL------------------AKSDPALIPRLVDEAVRWTAPVKSFMRTA 321 Query: 387 SSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFG 446 +D ++ +I G + + S R+ +F P+ ++ R+ + H+ FG+G Sbjct: 322 LADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEFDITRFPN--------RHLGFGWG 373 Query: 447 MRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPL 496 CLG+ LA+ EM + +L L+ L+ + +F+ P P+ Sbjct: 374 AHMCLGQHLAKLEMKIFFEELLPKLKSVELSGPPRLVATNFVGGPKNVPI 423 >6CVC-A nrPDB Length = 433 Score = 178 bits (450), Expect = 6e-45, Method: Composition-based stats. Identities = 64/384 (16%), Positives = 134/384 (34%), Gaps = 33/384 (8%) Query: 119 YRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQ 178 + H F PE + + +P + F M+ + Q L+ V + Sbjct: 73 HWALTKHDDIHFASRHPEIFHSSPNIVIHDQTPELAEYFGSMIV-LDDPRHQRLRSIVSR 131 Query: 179 NARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLM 238 + ++ S+ + H A L A + + +M Sbjct: 132 AFTPKVVARIEASVRERAHRLVAAMI-------ENHPDGQADLVSELAGPLPLQIICDMM 184 Query: 239 FMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQE---LAFSRPQQYTSIVAELLL 295 +P F + I +GD + + E ++ + T++ + + Sbjct: 185 GIPEEDHEQI--------FHWTNVILGFGDPDLTTDFDEFLQVSMAIGGYATALADDRRV 236 Query: 296 N--AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISE 353 N +L+ ++A + ++ + L +A N + A+ LA + E Sbjct: 237 NHHGDLTTSLVEAEVD---GERLSSSEIAMFFILLVVAGNETTRNAISHGMLALSRYPDE 293 Query: 354 HPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRN 413 + + L A++E +R +++ R S D+ L+ + AG V ++ S R+ Sbjct: 294 RAKWWSDFDGLAATAVEEIVRWASPVVYMRRTLSQDVDLRGTKMAAGDKVTLWYCSANRD 353 Query: 414 PALFPRPERYNPQRWLDIRGSGRNFYHVPF-GFGMRQCLGRRLAEAEMLLLLHHVLKHLQ 472 F P ++ R + + V F G G CLG LA E+ ++ + + + Sbjct: 354 EEKFADPWTFDVTRNPNPQ--------VGFGGGGAHFCLGANLARREIRVVFDELRRQMP 405 Query: 473 VETLTQEDIKMVYSFILRPSMFPL 496 T+E +++ FI P+ Sbjct: 406 DVVATEEPARLLSQFIHGIKRLPV 429 >2X2N-A nrPDB Length = 475 Score = 178 bits (450), Expect = 7e-45, Method: Composition-based stats. Identities = 75/431 (17%), Positives = 149/431 (34%), Gaps = 50/431 (11%) Query: 78 IFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHR--GHKCGVFLLNGP 135 IF ++ G + V P + P L P Y + + P Sbjct: 53 IFTINIVGKRVTIVGDPHE-----HSRFFLPRNEVLSPREVYSFMVPVFGEGVAYAAPYP 107 Query: 136 EWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHY 195 R L E L+ Q F+P + R F + ++ +++ Sbjct: 108 RMREQ-LNFLAEELTIAKFQNFVPAIQHEVRKF---MAANWDKDEGE---INLLEDCSTM 160 Query: 196 TIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKE 255 I + LFGE L + F L M S + L + P+ + Sbjct: 161 IINTACQCLFGEDL-----RKRLDARRFAQLLAKMESSLIPAAVFLPILLKLPLPQSARC 215 Query: 256 HFEAWDCIFQYGDNCIQKIYQELAFSR-----------PQQYTSIVAELLLNAE-LSPDA 303 H +QKI E+ +R + +++ + + +S Sbjct: 216 H---------EARTELQKILSEIIIARKAAAVNKDSSTSDLLSGLLSAVYRDGTPMSLHE 266 Query: 304 IKANSMELTAGSVDTTVFPLLMTLFELARNPNVQ--QALRQESLAAAASISEHPQKATTE 361 + + T+ ++ L NV+ +ALR+E A ++ + E Sbjct: 267 VCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEFPAQLNYN--NVMDE 324 Query: 362 LPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPE 421 +P +E++R P L L R +D+ + +Y +P G ++ + FP P Sbjct: 325 MPFAERCARESIRRDPPLLMLMRKVMADVKVGSYVVPKGDIIACSPLLSHHDEEAFPEPR 384 Query: 422 RYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQE-D 480 R++P+R + G+ + FG G+ +C+G++ ++ +L + + L E Sbjct: 385 RWDPERDEKVEGA-----FIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQLLRDEVP 439 Query: 481 IKMVYSFILRP 491 ++ ++ P Sbjct: 440 DPDYHTMVVGP 450 >2ZBZ-A nrPDB Length = 412 Score = 178 bits (450), Expect = 8e-45, Method: Composition-based stats. Identities = 83/436 (19%), Positives = 145/436 (33%), Gaps = 81/436 (18%) Query: 76 GPIFRYDLG-GAGMVCVMLPEDVEKLQQVDSLHPHRMSL------EPWVAYRQHRGHKCG 128 GP+ R L G V E KL L +R + A R+ G Sbjct: 38 GPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSPAFEAVRESPQAFIG 97 Query: 129 VFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDV 188 + P R R+ + ++ P V+ V F + Sbjct: 98 L----DPPEHGTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEMLAA------------- 140 Query: 189 QPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWT 248 G LV + L + + + F + R Sbjct: 141 -----------------GPTADLVSQFALPVPSMVICRLLGVPYADHE--FFQDASKRLV 181 Query: 249 SPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANS 308 + A + + Y D I + E ++VA+ L N E+ + + + + Sbjct: 182 QSTDAQSALTARNDLAGYLDGLITQFQTEPGAGL---VGALVADQLANGEIDREELISTA 238 Query: 309 MELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAA 368 M L +TT +++ L +P ALR + L+ A Sbjct: 239 MLLLIAGHETTASMTSLSVITLLDHPEQYAALRADR------------------SLVPGA 280 Query: 369 LKETLRLYPVGLFL-ERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQR 427 ++E LR + RVA++D+ ++ I AG V V R+ ++ P+ + R Sbjct: 281 VEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRDGTVYEDPDALDIHR 340 Query: 428 WLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSF 487 +H+ FGFG+ QCLG+ LA E+ ++L+ ++ + L V Sbjct: 341 SA--------RHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTLRLAV----PVEQL 388 Query: 488 ILRPSMFPLLTFRAIN 503 +LRP T + +N Sbjct: 389 VLRPGT----TIQGVN 400 >3MGX-A nrPDB Length = 415 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 55/267 (20%), Positives = 106/267 (39%), Gaps = 31/267 (11%) Query: 235 VQLMFMPRSLSRWT---SPKVWKEHFEAWDCIF-QYGDNCIQKIYQELAFSRP-QQYTSI 289 +++ +P + + E +D + + I + EL +R + + Sbjct: 170 CEILGVPAEDEDMLIDLTNHAFGGEDELFDGMTPRQAHTEILVYFDELITARRKEPGDDL 229 Query: 290 VAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAA 349 V+ L+ + +L+ D + N + G +TT + + LA P + ALR S Sbjct: 230 VSTLVTDDDLTIDDVLLNCDNVLIGGNETTRHAITGAVHALATVPGLLTALRDGSADV-- 287 Query: 350 SISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYS 409 ++E LR + + RV ++D+ + +P+GT V +L + Sbjct: 288 ----------------DTVVEEVLRWTSPAMHVLRVTTADVTINGRDLPSGTPVVAWLPA 331 Query: 410 LGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 R+PA F P+ + P R + H+ FG GM CLG LA E+ ++L + + Sbjct: 332 ANRDPAEFDDPDTFLPGR--------KPNRHITFGHGMHHCLGSALARIELSVVLRVLAE 383 Query: 470 HLQVETLTQEDIKMVYSFILRPSMFPL 496 + L +E + + P+ Sbjct: 384 RVSRVDLEREPAWLRAIVVQGYRELPV 410 >4PWV-A nrPDB Length = 446 Score = 174 bits (441), Expect = 7e-44, Method: Composition-based stats. Identities = 65/333 (19%), Positives = 119/333 (35%), Gaps = 37/333 (11%) Query: 169 SQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALE 228 + L+ +L++ + I T A LN + L Sbjct: 126 HRGLRNVLLKSFSPQALKPIVDQIRVNTTRLVVDAARRGECDFAADVAEQIPLNTISDLL 185 Query: 229 VMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTS 288 + + + + S +S + +AW N I + EL R + T Sbjct: 186 GVPAADREFLLKLNK-SALSSEDADQSATDAW-----LARNEILLYFSELVAERRAKPTE 239 Query: 289 IVAELLLNA-----ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE 343 V +L N+ L+ + I N L G +T+ ++ ++ + P+ + LR Sbjct: 240 DVISVLANSMVDGKPLTEEVIVLNCYSLILGGDETSRLSMIDSVQTFTQYPDQWELLRDG 299 Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLV 403 + L +A +E LR + R A +D+ L I AG +V Sbjct: 300 KVT------------------LESATEEVLRWATPAMHFGRRAVTDMELHGQVIAAGDVV 341 Query: 404 RVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLL 463 ++ S R+ +F P ++ R + H+ FG+G CLG L AE+ L Sbjct: 342 TLWNNSANRDEEVFADPYAFDLNRSPNK--------HITFGYGPHFCLGAYLGRAEVHAL 393 Query: 464 LHHVLKHLQVETLTQEDIKMVYSFILRPSMFPL 496 L + + +T E ++ +F+ S P+ Sbjct: 394 LDALRTYTTGFEITGEPQRIHSNFLTGLSRLPV 426 >5DQN-A nrPDB Length = 426 Score = 174 bits (441), Expect = 7e-44, Method: Composition-based stats. Identities = 52/347 (14%), Positives = 108/347 (31%), Gaps = 40/347 (11%) Query: 146 PEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALF 205 P+ ++ AV ++ + L+K + + ++ + + + A Sbjct: 84 PQDMTREAVDLQRAVLLNMDAPQHTRLRKIISRGFTPRAIGRLEDELRSRAQKIAQTAAA 143 Query: 206 GERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQ 265 V L + L + + +F RW++ E E D Sbjct: 144 QGAGDFVEQVSCELPLQAIAELLGVPQDDRDKLF------RWSNEMTAGEDPEYADVDPA 197 Query: 266 YGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKAN-----SMELTAGSVDTTV 320 + ++A R T + L+ A++ + + + + L +TT Sbjct: 198 MSSFELISYAMKMAEERAVNPTEDIVTKLIEADIDGEKLSDDEFGFFVVMLAVAGNETTR 257 Query: 321 FPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGL 380 + + A+NP+ + ++E A E +R Sbjct: 258 NSITHGMIAFAQNPDQWELYKKERP--------------------ETAADEIVRWATPVS 297 Query: 381 FLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYH 440 +R A D+ L I G V + S + +F P +N R + H Sbjct: 298 AFQRTALEDVELGGVQIKKGQRVVMSYRSANFDEEVFEDPHTFNILRSPN--------PH 349 Query: 441 VPFGF-GMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYS 486 V FG G C+G LA + L+ + + ++ ++ Sbjct: 350 VGFGGTGAHYCIGANLARMTINLIFNAIADNMPDLKPIGAPERLKSG 396 >2WIO-A nrPDB Length = 431 Score = 174 bits (440), Expect = 9e-44, Method: Composition-based stats. Identities = 63/350 (18%), Positives = 113/350 (32%), Gaps = 43/350 (12%) Query: 160 MVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSA 219 M+ + +AL+K V D++P I T A GE LV Sbjct: 106 MIHEIDPPEHRALRKVVSSAFTPRTISDLEPRIRDVTRSLLADA--GESFDLVDVLAFPL 163 Query: 220 SLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWD-----CIFQYGDNCIQKI 274 + + L + W+ V + + D I + + Sbjct: 164 PVTIVAELLGLPPMD------HEQFGDWSGALVDIQMDDPTDPALAERIADVLNPLTAYL 217 Query: 275 YQELAFSRPQQYTSIVAELLLNA----ELSPDAIKANSMELTAGSVDTTVFPLLMTLFEL 330 A R +++ L+L L + S L TT L + L Sbjct: 218 KARCAERRADPGDDLISRLVLAEVDGRALDDEEAANFSTALLLAGHITTTVLLGNIVRTL 277 Query: 331 ARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDL 390 +P A ++ + A ++E LR P ++R + Sbjct: 278 DEHPAHWDAAAEDPGR------------------IPAIVEEVLRYRPPFPQMQRTTTKAT 319 Query: 391 VLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQC 450 + IPA +V ++ S R+ P+R++P R + FG G+ C Sbjct: 320 EVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSR------KSGGAAQLSFGHGVHFC 373 Query: 451 LGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVY--SFILRPSMFPLLT 498 LG LA E + L ++ T+ ++D ++ + +L P+L Sbjct: 374 LGAPLARLENRVALEEIIARFGRLTVDRDDERLRHFEQIVLGTRHLPVLA 423 >5FOI-A nrPDB Length = 408 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 58/317 (18%), Positives = 114/317 (35%), Gaps = 33/317 (10%) Query: 169 SQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLAL-FGERLGLVGHSPSSASLNFLHAL 227 L++ + ++P I + L + ++ H S + L Sbjct: 107 HTRLRRMFISAFSVRQVETMRPEIEKIVDGILDRLLALEPPVDILTHLALPMSTQVICHL 166 Query: 228 EVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYT 287 + + L+ + + + + + + A Sbjct: 167 LGVPYEDREFFQERSELASRP------NDDRSMPALIELVEYLDGLVRTKTAHPDTGLLG 220 Query: 288 SIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAA 347 + V E LL E++ + N++ L A +T+ + +++ L R+P LR++ Sbjct: 221 TAVTERLLKGEITHQELVNNAVLLLAAGHETSANQVTLSVLTLLRHPETAAELREQPE-- 278 Query: 348 AASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFL 407 L+ A+ E LR + + L R A++D+VL ++ I AG + + L Sbjct: 279 ----------------LMPNAVDELLRYHSIADGLRRAATADIVLGDHTIRAGDGLIILL 322 Query: 408 YSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHV 467 S + F ++ R +HV FG+G QCLG+ LA EM + L + Sbjct: 323 SSANHDGNTFGAEATFDIHR--------PARHHVAFGYGPHQCLGQNLARLEMEVTLGKL 374 Query: 468 LKHLQVETLTQEDIKMV 484 + + L QE + Sbjct: 375 FRRVPALRLAQEPDALR 391 >5CJE-A nrPDB Length = 393 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 79/417 (18%), Positives = 134/417 (32%), Gaps = 44/417 (10%) Query: 81 YDLGGAGMVCVMLPEDVEKLQQVDSL-HPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRF 139 DLG G P V + H R GH+ L P Sbjct: 5 IDLGEYGARFTEDPYPVYAELRERGPVHWVRTPPPEAFEGWLVVGHEEARAALADPRLSK 64 Query: 140 NRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEA 199 + + L+ V+ P + V L+ V + ++P I T Sbjct: 65 DG---TKKGLTSLDVELMGPYLLVVDPPEHTRLRSLVARAFTMRRVEALRPRIQEITDGL 121 Query: 200 SNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEA 259 + L R LV + + L + + + + +P A Sbjct: 122 LDEMLPRGRADLVDSFAYPLPITVICELLGVP--DIDRVTFRALSNEIVAPTGGDAELAA 179 Query: 260 WDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELL-----LNAELSPDAIKANSMELTAG 314 ++ + Y D I ++ +L+ + LS + ++A + L Sbjct: 180 YERLAAYLDELIDDKRS------TAPADDLLGDLIRTRAEDDDRLSGEELRAMAFILLVA 233 Query: 315 SVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLR 374 +TTV + + L +P+ ALR ++ LL A++E LR Sbjct: 234 GHETTVNLITNGVHTLLTHPDQLAALR------------------ADMTLLDGAVEEVLR 275 Query: 375 LY-PVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRG 433 PV R A+ + + I G V + L + GR+PA P P ++ R Sbjct: 276 FEGPVETATYRYAAESMEIGGTAIAEGDPVMIGLDAAGRDPARHPDPHVFDIHR------ 329 Query: 434 SGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILR 490 H+ FG G+ CLG LA E + L +L+ L ++R Sbjct: 330 --APQGHLAFGHGIHYCLGAPLARLEARVALRSLLERCPDLALDGPPGARPPGMLIR 384 >3A50-A nrPDB Length = 411 Score = 172 bits (436), Expect = 3e-43, Method: Composition-based stats. Identities = 71/357 (19%), Positives = 136/357 (38%), Gaps = 64/357 (17%) Query: 159 PMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSS 218 PM+ + L+K V ++ +++P I GL+ P+ Sbjct: 85 PMMILMDPPDHTRLRKLVGRSFTVRRMNELEPRITEIA------------DGLLAGLPTD 132 Query: 219 ASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIF------QYGDNCIQ 272 ++ + E F+ VQ++ L P ++ F AW + + + Sbjct: 133 GPVDLMR--EYAFQIPVQVICELLGL-----PAEDRDDFSAWSSVLVDDSPADDKNAAMG 185 Query: 273 KIYQELAF----SRPQQYTSIVAELLLNAELSPD-----AIKANSMELTAGSVDTTVFPL 323 K++ L+ R + ++++ LL +++ D + A +M L +TTV + Sbjct: 186 KLHGYLSDLLERKRTEPDDALLSSLLAVSDMDGDRLSQEELVAMAMLLLIAGHETTVNLI 245 Query: 324 LMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRL-YPVGLFL 382 + L +P+ ++ L ++ L+ +A++E LR PV Sbjct: 246 GNGVLALLTHPDQRKLLAEDP------------------SLISSAVEEFLRFDSPVSQAP 287 Query: 383 ERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVP 442 R + D+ IPAG +V + L + R+ P P+R + R SG F Sbjct: 288 IRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITR----DASGGVF---- 339 Query: 443 FGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVY---SFILRPSMFPL 496 FG G+ CLG +LA E + + + L ++VY + + S P+ Sbjct: 340 FGHGIHFCLGAQLARLEGRVAIGRLFADRPELALAVGLDELVYRRSTLVRGLSRMPV 396 >6B11-A nrPDB Length = 440 Score = 172 bits (435), Expect = 4e-43, Method: Composition-based stats. Identities = 59/276 (21%), Positives = 105/276 (38%), Gaps = 31/276 (11%) Query: 209 LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGD 268 L + A L AL + + +L+ +P + + + A Sbjct: 169 LDDLTARGDEADLLADFALPMATQVICRLLDIPYEDRDYFQERTEQATRPAAGEEALEAL 228 Query: 269 NCIQKIYQELAFSR--PQQYTSIVAELLLNAE---LSPDAIKANSMELTAGSVDTTVFPL 323 ++ L + + ++ ++ A LS + N++ L A +TT + Sbjct: 229 LELRDYLDRLISGKTGRESGDGMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMV 288 Query: 324 LMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 383 M++ L ++P + L T LL A+ E LR + L Sbjct: 289 TMSVLVLLQHPTAWREL------------------TVNPGLLPGAVDELLRYLSIADGLR 330 Query: 384 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF 443 R A++D+ + + I AG + L + R+ A+F PE ++ R HV F Sbjct: 331 RSATADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHRSA--------RRHVAF 382 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQE 479 G+G QCLG+ LA E+ + L VL+ L T + Sbjct: 383 GYGPHQCLGQNLARMELEVALGAVLERLPALRPTTD 418 >6GMF-A nrPDB Length = 397 Score = 171 bits (433), Expect = 6e-43, Method: Composition-based stats. Identities = 69/396 (17%), Positives = 129/396 (32%), Gaps = 43/396 (10%) Query: 109 HRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDF 168 R+ + ++A +++ + G NR P + V Sbjct: 30 GRLQPQGFMAVGRYQDVARVLHDAKG---FSNRGWAASLPRGVKWDTSMPPSIVQVDPPR 86 Query: 169 SQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALE 228 L+ V + ++P I E + + + + Sbjct: 87 HGKLRTLVTKAFTPRTVAQLEPRIRDIAHELVDGLRGKSTFEATVEVTVPMPMIVIAEML 146 Query: 229 VMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQ--KIYQELAFSRPQQY 286 + RW+ V Q + + + E+ R ++ Sbjct: 147 GVAPERR------ADFKRWSDDMVGSLALVRVGNAAQLERSTQEFYAYFSEVLEERRREP 200 Query: 287 TSIVAELLLNAELSPDAIKANSME-----LTAGSVDTTVFPLLMTLFELARNPNVQQALR 341 + LL AE+ + + A + L +TT + L L +P A + Sbjct: 201 REDLISQLLAAEVDGEKLTAGEVLSFANTLLIAGNETTTSLIGNALVALTDHPEQLAAAQ 260 Query: 342 QESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGT 401 +L L+ A ++E LR + R +D+ + + IPA + Sbjct: 261 ------------------ADLSLVPAVVEEVLRYESPAQCIFRQTMTDVEIGDERIPARS 302 Query: 402 LVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEML 461 +V L S R+ + FP P+R++ R H+ FG + C+G LA E Sbjct: 303 VVLPLLASANRDESRFPDPDRFDIHR--------DTKGHLAFGLDIHFCIGAPLARLEAK 354 Query: 462 LLLHHVLKHL-QVETLTQEDIKMVYSFILRPSMFPL 496 ++L +L L ++ ++QE FI PS PL Sbjct: 355 VMLEVLLARLGDIQRVSQEVSWSPSFFIRSPSTLPL 390 >5Y1I-A nrPDB Length = 403 Score = 171 bits (433), Expect = 7e-43, Method: Composition-based stats. Identities = 69/399 (17%), Positives = 133/399 (33%), Gaps = 39/399 (9%) Query: 94 PEDVEKLQQVDSLHPHRMSL--EPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLN-PEVLS 150 P V KL L R+ PWV R LL+ P + LR P + + Sbjct: 21 PPGVRKLLAEKPLSRARIWDGSTPWVVTRHADQRA----LLSDPRVSHDGLRDGYPHISA 76 Query: 151 PNAVQRFL-PMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFG-ER 208 P +++ V ++P+I T E + L G + Sbjct: 77 DFKFLSMAQPSFAGQDDPEHGRIRRMVTLPFTARRIEAMRPAIQKITDELIDGMLAGPKP 136 Query: 209 LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGD 268 + LV + + + + + + + + A Sbjct: 137 VDLVEALALPVPVRVICEMLGVPYEDREFLQQNNNAMIYRDTAQGDAQKAAIAQAM---- 192 Query: 269 NCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLF 328 ++++ R S +A + E++ D M L +TT + + Sbjct: 193 -YLKELVGTKLGDRGDDILSDLAVQVEAGEITQDDAAGIGMMLLGAGHETTANMIALGTL 251 Query: 329 ELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGL-FLERVAS 387 L NP +R + + ++ ++E LR + + R+A+ Sbjct: 252 ALLENPEQLAEVR----------------DSDDPKVIVNTVEELLRYLTIAQDTVRRIAA 295 Query: 388 SDLVLQNYHIPAGTLVRVFLYSLGRNPALFPR-PERYNPQRWLDIRGSGRNFYHVPFGFG 446 D+ + I AG + L + +P L+P P+R + R H+ FG+G Sbjct: 296 EDIEIGGVVIKAGEGIVFPLNAANWDPDLYPEAPDRLDIHR-------ANARRHLAFGYG 348 Query: 447 MRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVY 485 + QCLG LA E+ ++ +L+ + L ++ + Sbjct: 349 VHQCLGATLARVELQIVYSTLLRRIPTLALAGTLDEIPF 387 >2VZM-A nrPDB Length = 436 Score = 171 bits (432), Expect = 9e-43, Method: Composition-based stats. Identities = 80/444 (18%), Positives = 141/444 (31%), Gaps = 52/444 (11%) Query: 65 HLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRG 124 H+ Q P DLG G P + + HR+ G Sbjct: 20 HMRRTQQGTTASPPV-LDLGALGQDFAADPYPTYARLRAEGP-AHRVRTPEGNEVWLVVG 77 Query: 125 HKCGVFLLNGPEWRFN-RLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGS 183 + +L P + + R P + A+ + L+K V + Sbjct: 78 YDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNM---LESDPPRHTRLRKLVAREFTMR 134 Query: 184 LTLDVQPSIFHYTIEA--SNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMP 241 ++P + + LA R L+ + + L + + + Sbjct: 135 RVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISELLGVPEPDRAAFRVW 194 Query: 242 RSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAE--- 298 + P + A + Y I R Q +++ L+ ++ Sbjct: 195 TD--AFVFPDDPAQAQTAMAEMSGYLSRLIDS-------KRGQDGEDLLSALVRTSDEDG 245 Query: 299 --LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQ 356 L+ + + + L +TTV + ++ L +P+ ALR Sbjct: 246 SRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALR--------------- 290 Query: 357 KATTELPLLRAALKETLRLY-PVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPA 415 ++ LL A++E LR PV R + L IPAG V V L R P Sbjct: 291 ---ADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPE 347 Query: 416 LFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVET 475 FP P R++ +R H+ FG G+ C+G LA E + + +L+ Sbjct: 348 RFPDPHRFDIRR--------DTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLA 399 Query: 476 LTQEDIKMVY---SFILRPSMFPL 496 L ++V+ I P+ Sbjct: 400 LDVSPGELVWYPNPMIRGLKALPI 423 >4Z5P-A nrPDB Length = 400 Score = 169 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 64/373 (17%), Positives = 125/373 (33%), Gaps = 51/373 (13%) Query: 138 RFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTI 197 RF+R ++ + + R + ++ L++ + + +Q + Sbjct: 63 RFSRAQIGEDTPRTTPLARRSDTILSLDPPEHTRLRRLLSKAFTARRMGAMQSWLEE--- 119 Query: 198 EASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHF 257 LF L V + A + A +L+ +P + W E Sbjct: 120 ------LFAGLLDGVERTGHPADIVRDLAQPFTIAVICRLLGVPYEDRGRF--QHWSEVI 171 Query: 258 EAWDCIFQY----GDNCIQKIYQELAFSRPQQYTSIVAELL-----LNAELSPDAIKANS 308 + + D I+ +L +R + +L + L+ D + Sbjct: 172 MSTTAYSKEEAVSADASIRAYLADLVSARRAAPHDDLLGVLVSARDDDDRLTEDELITFG 231 Query: 309 MELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAA 368 + L +T+ L ++ L + + LR++ LL A Sbjct: 232 VTLLVAGHETSAHQLGNMVYALLTHEDQLSLLREQPE------------------LLPRA 273 Query: 369 LKETLRLYPVGLFL--ERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQ 426 ++E LR P+G + R+A D+ L + AG V + R+P F P+R + Sbjct: 274 VEELLRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLDIT 333 Query: 427 RWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVY- 485 R H+ FG G CLG +LA E+ + + +L+ L ++ + Sbjct: 334 R--------EKNPHLAFGHGAHYCLGAQLARMELRVAIGGLLERFPGLRLAVPADQVEWK 385 Query: 486 --SFILRPSMFPL 496 P P+ Sbjct: 386 TGGLFRGPQRLPI 398 >2Y5N-A nrPDB Length = 417 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 74/408 (18%), Positives = 143/408 (35%), Gaps = 47/408 (11%) Query: 100 LQQVDSLHPHRMS--LEPWVA--YRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQ 155 LQ+ + + R E W+ Y R + GP + R PE++ Sbjct: 46 LQETEPVSRVRPPYGEEAWLVTRYEDVRAVLGDGRFVRGPSMTRDEPRTRPEMVKG---- 101 Query: 156 RFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASN-LALFGERLGLVGH 214 + ++ L++ V++ ++P E + +A G+ LV Sbjct: 102 ----GLLSMDPPEHSRLRRLVVKAFTARRAESLRPRAREIAHELVDQMAATGQPADLVAM 157 Query: 215 SPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKI 274 + + L + + T+ +E EA + + Y + I + Sbjct: 158 FARQLPVRVICELLGVPSADHDRFTRWSGAFLSTAEVTAEEMQEAAEQAYAYMGDLIDRR 217 Query: 275 YQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNP 334 +E +++V LS + ++ L ++T + ++ L P Sbjct: 218 RKEPTD---DLVSALVQARDQQDSLSEQELLDLAIGLLVAGYESTTTQIADFVYLLMTRP 274 Query: 335 NVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYP--VGLFLERVASSDLVL 392 +++ L L+ +A++E R P VG R A D+ L Sbjct: 275 ELRRQL------------------LDRPELIPSAVEELTRWVPLGVGTAFPRYAVEDVTL 316 Query: 393 QNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLG 452 + I AG V + R+ A FP +R + R + H+ FG G+ CLG Sbjct: 317 RGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDRTPN--------QHLGFGHGVHHCLG 368 Query: 453 RRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYS---FILRPSMFPLL 497 LA E+ + L +L+ L L + ++ +S + P P++ Sbjct: 369 APLARVELQVALEVLLQRLPGIRLGIPETQLRWSEGMLLRGPLELPVV 416 >6GK6-A nrPDB Length = 411 Score = 168 bits (426), Expect = 4e-42, Method: Composition-based stats. Identities = 83/407 (20%), Positives = 141/407 (34%), Gaps = 60/407 (14%) Query: 110 RMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAV----- 164 R+ + WVA R + V LL P RL + L +R+ P+ D Sbjct: 39 RLDVPIWVAVR----YDDCVELLKDP-----RLIRDFRKLPDEVRRRYFPLSDRTTFMDQ 89 Query: 165 -----ARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSA 219 L+ V + + ++P I + + R+ L+ Sbjct: 90 HMLDADPPDHTRLRAIVQRAFSPRMMEGLRPRIQEIADGLIDAVIDRRRMELIADFAFPL 149 Query: 220 SLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELA 279 + L + RWT + + Q ++ LA Sbjct: 150 PTAVIAELLGLPVEDR------GRFRRWTKILLAPAKDREFVERAQPVVEEFAAYFRALA 203 Query: 280 FSRPQQYTSIVAELLLNAE-----LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNP 334 +R + + LL AE LSP + + L +TTV + + L +P Sbjct: 204 DARRKAPRDDLISGLLLAEEQEHKLSPAELSSMVFLLLVAGHETTVHLIASGMLLLLSHP 263 Query: 335 NVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLY-PVGLFLERVASSDLVLQ 393 ++ L ++ L+ +A++E LR P L R + D+ L Sbjct: 264 AERRRLDEDP------------------GLVGSAVEEALRCEGPAELSTIRWSLEDIELF 305 Query: 394 NYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGR 453 +PAG V L + R+P FP P+R++ R + H+ FG G+ CLG Sbjct: 306 GARVPAGEGVAAGLLAANRDPQHFPDPDRFDIGRSPN--------RHIGFGGGIHFCLGA 357 Query: 454 RLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYS---FILRPSMFPLL 497 LA E + +L+ L L +V+S I P+ P++ Sbjct: 358 MLARIEAAIAFSTLLRRLPRIELATSTRDIVWSEWPTIRGPAAVPVV 404 >4GGV-A nrPDB Length = 418 Score = 168 bits (426), Expect = 4e-42, Method: Composition-based stats. Identities = 55/327 (16%), Positives = 105/327 (32%), Gaps = 35/327 (10%) Query: 161 VDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSAS 220 + + + ++ V + L D++ + T E + + + Sbjct: 95 MSQMDPPRHRKYRQLVSRAFTPRLVADMETRVADITRELLDAVDGKPEIEIAADLAYPLP 154 Query: 221 LNFLHALEVMFKSTVQLMFMPRSLSRWTSP---------KVWKEHFEAWDCIFQYGDNCI 271 + + L + L + ++ +A + + D Sbjct: 155 VIVIAELLGVPAGDRDLFKKWADDIIEGFSGFSFLDTSGQGEQDVRDATERLRPLLDYMA 214 Query: 272 QKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELA 331 + + R T +V + L+ + I + L TT L T+ L Sbjct: 215 GHVTERRRTPREDLLTHLVQAEVDGERLTDNEIVNVANILLVTGHITTTMTLGNTVLCLD 274 Query: 332 RNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLV 391 +P V +R + L+ A++E LR+ L R S ++ Sbjct: 275 ADPEVAAKVRADR------------------SLVPGAIEEALRVLSPSAALARGTSREVE 316 Query: 392 LQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCL 451 + IP +V ++L + R+P F PE Y+P R + H FG G+ CL Sbjct: 317 VAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVYDPTRDPN--------PHFGFGRGIHFCL 368 Query: 452 GRRLAEAEMLLLLHHVLKHLQVETLTQ 478 G LA E + L+ + V Sbjct: 369 GAPLARLEGRVALNALFDRFPVLRTDP 395 >4YZR-A nrPDB Length = 405 Score = 168 bits (425), Expect = 5e-42, Method: Composition-based stats. Identities = 60/343 (17%), Positives = 111/343 (32%), Gaps = 43/343 (12%) Query: 163 AVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLN 222 A L+ V Q +++ SI + + + ++ S Sbjct: 93 AKDTPDHTRLRSLVHQAFTPRTIENLRGSIEQIAEQLLDEMEKENKADIMKSFASPLPFI 152 Query: 223 FLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSR 282 + L + K WT+ V + E + + +L R Sbjct: 153 VISELMGIPKEDR------SQFQIWTNAMV--DTSEGNRELTNQALREFKDYIAKLIHDR 204 Query: 283 PQQYTSIVAELLLNAE-----LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQ 337 + + L++AE LS + + L ++TTV L L ++ Sbjct: 205 RIKPKDDLISKLVHAEENGSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQH---- 260 Query: 338 QALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE-RVASSDLVLQNYH 396 + +K + ++ A++E LR + + R A D + + Sbjct: 261 --------------KKECEKLKQQPEMIATAVEELLRYTSPVVMMANRWAIEDFTYKGHS 306 Query: 397 IPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLA 456 I G ++ + + S R+P F PE N R + H+ FGFG+ CLG LA Sbjct: 307 IKRGDMIFIGIGSANRDPNFFENPEILNINRSPN--------RHISFGFGIHFCLGAPLA 358 Query: 457 EAEMLLLLHHVLKHLQVETLTQEDIKMVYS---FILRPSMFPL 496 E + +LK L + + F+ P+ Sbjct: 359 RLEGHIAFKALLKRFPDIELAVAPDDIQWRKNVFLRGLESLPV 401 >3ABB-A nrPDB Length = 408 Score = 168 bits (424), Expect = 8e-42, Method: Composition-based stats. Identities = 56/290 (19%), Positives = 104/290 (35%), Gaps = 37/290 (12%) Query: 196 TIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWT------- 248 I +L L + A L AL V + +L+ +P + Sbjct: 120 AIRPRLQSLVDRLLDDMLAKGPGADLVSAFALPVPSVAICELLGVPYGDHDFFEECSRNF 179 Query: 249 -SPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKAN 307 E A+ ++ Y + + E + ++A L +L D + Sbjct: 180 VGAATSAEADAAFGELYTYLHGLVGRKQAEPEDGLLDE---LIARQLEEGDLDHDEVVMI 236 Query: 308 SMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRA 367 ++ L +TTV + + L ++P L ++ A + Sbjct: 237 ALVLLVAGHETTVNAIALGALTLIQHPEQIDVLLRDPGAVSG------------------ 278 Query: 368 ALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQR 427 ++E LR V + R+A D+ + I AG V V + + R+ + P+ ++ +R Sbjct: 279 VVEELLRFTSVSDHIVRMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDIFDARR 338 Query: 428 WLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLT 477 +HV FG G+ QCLG+ LA AE+ + L + + L Sbjct: 339 --------NARHHVGFGHGIHQCLGQNLARAELEIALGGLFARIPGLRLA 380 >5XJN-A nrPDB Length = 455 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 57/372 (15%), Positives = 117/372 (31%), Gaps = 34/372 (9%) Query: 132 LNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPS 191 N R ++++ + + A ++ + ++P Sbjct: 107 ENAQAPVRKRGPQATQIMTDGGFTAY-SGLSARIPPEHTRIRAIAQKAFTPRRYKALEPD 165 Query: 192 IFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPK 251 I I+ L ++ S + + + L + + + ++ + S + Sbjct: 166 IRAMVIDRVEKMLANDQHVGDMVSDLAYDIPTITILT-LIGADISMVDTYKRWSDSRAAM 224 Query: 252 VWKEHFEAWDCIFQYG-----DNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKA 306 W + + + C + + A +V E++ I + Sbjct: 225 TWGDLSDEEQIPHAHNLVEYWQECQRMVADAHAHGGDNLTADLVRAQQEGQEITDHEIAS 284 Query: 307 NSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLR 366 L +TT + L +P QA+ + L+ Sbjct: 285 LLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILE------------------NPKLIP 326 Query: 367 AALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQ 426 AA+ E LR + R A D + I G V + + S R+ A F E ++ Sbjct: 327 AAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEFDIS 386 Query: 427 RWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQ-VETLTQEDIKMVY 485 R H+ FGFG+ CLG LA+ + + L V + + + + + I Sbjct: 387 R-------ANAREHLSFGFGIHYCLGNMLAKLQAKICLEEVTRLVPSLHLVADKAIGFRE 439 Query: 486 SFILR-PSMFPL 496 + R P+ P+ Sbjct: 440 NLSFRVPTSVPV 451 >4WPZ-A nrPDB Length = 397 Score = 166 bits (421), Expect = 2e-41, Method: Composition-based stats. Identities = 71/351 (20%), Positives = 128/351 (36%), Gaps = 58/351 (16%) Query: 164 VARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNF 223 + L+K V + ++P I L G+ L + P L Sbjct: 85 MDAPEHTRLRKLVTKAFTARRVETLRPRITE---------LVGQLLDELETLPRPVDLVK 135 Query: 224 LHALEVMFKSTVQLMFMPRS----LSRWTSPKV--WKEHFEAWDCIFQYGDNCIQKIYQE 277 ++ + + +L+ +P W++ + W++ E + + E Sbjct: 136 NFSVPLPVRVICELLGVPAGDQDTFHAWSNALLGDWQQVVEKEAATVS-----LVNYFGE 190 Query: 278 L-AFSRPQQYTSIVAELLL----NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELAR 332 L A R +++EL+ ++ L+ I A S+ + + +TT + M L L Sbjct: 191 LIAVKRENPADDLISELIAISDGDSTLTEREIIALSIGILSAGHETTANQISMFLVTLLH 250 Query: 333 NPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYP---VGLFLERVASSD 389 NP LR A + A+ E LR P G + R+ +++ Sbjct: 251 NPEELDKLRDNREA------------------IPKAVDELLRFVPLTTTGGIIPRLTTAE 292 Query: 390 LVL-QNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMR 448 + L +PAG +V + + R+P +F ER N R N H+ FG G+ Sbjct: 293 VELSGGQVLPAGAVVLPAVATANRDPEVFEDGERLNVTR--------ENNPHLAFGAGIH 344 Query: 449 QCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVY---SFILRPSMFPL 496 CLG +LA E+ L +L + L + ++ S I P+ Sbjct: 345 HCLGAQLARIELQEALGAILDRMPQVRLAVPESELRLKSASIIRGLESLPI 395 >5GWE-A nrPDB Length = 405 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 57/372 (15%), Positives = 117/372 (31%), Gaps = 34/372 (9%) Query: 132 LNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPS 191 N R ++++ + + A ++ + ++P Sbjct: 57 ENAQAPVRKRGPQATQIMTDGGFTAY-SGLSARIPPEHTRIRAIAQKAFTPRRYKALEPD 115 Query: 192 IFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPK 251 I I+ L ++ S + + + L + + + ++ + S + Sbjct: 116 IRAMVIDRVEKMLANDQHVGDMVSDLAYDIPTITILT-LIGADISMVDTYKRWSDSRAAM 174 Query: 252 VWKEHFEAWDCIFQYG-----DNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKA 306 W + + + C + + A +V E++ I + Sbjct: 175 TWGDLSDEEQIPHAHNLVEYWQECQRMVADAHAHGGDNLTADLVRAQQEGQEITDHEIAS 234 Query: 307 NSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLR 366 L +TT + L +P QA+ + L+ Sbjct: 235 LLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILE------------------NPKLIP 276 Query: 367 AALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQ 426 AA+ E LR + R A D + I G V + + S R+ A F E ++ Sbjct: 277 AAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEFDIS 336 Query: 427 RWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQ-VETLTQEDIKMVY 485 R H+ FGFG+ CLG LA+ + + L V + + + + + I Sbjct: 337 R-------ANAREHLSFGFGIHYCLGNMLAKLQAKICLEEVTRLVPSLHLVADKAIGFRE 389 Query: 486 SFILR-PSMFPL 496 + R P+ P+ Sbjct: 390 NLSFRVPTSVPV 401 >3R9C-A nrPDB Length = 418 Score = 166 bits (419), Expect = 3e-41, Method: Composition-based stats. Identities = 60/331 (18%), Positives = 109/331 (32%), Gaps = 35/331 (10%) Query: 167 DFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHA 226 L+ V + + ++P I + + A+ G L+ + + + Sbjct: 103 PDHTRLRGLVSKAFAPRVIKRLEPEITALVDQLLD-AVDGPEFNLIDNLAYPLPVAVICR 161 Query: 227 LEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQ--YGDNCIQKIYQELAFSRPQ 284 L + +L E D + ++ + L R + Sbjct: 162 LLGVPIEDEPKFSRASALLAAALDPFLALTGETSDLFDEQMKAGMWLRDYLRALIDERRR 221 Query: 285 QYTSIVAELLL-----NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQA 339 + L+ +L+ D I A L +TTV + + R P A Sbjct: 222 TPGEDLMSGLVAVEESGDQLTEDEIIATCNLLLIAGHETTVNLIANAALAMLRTPGQWAA 281 Query: 340 LRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPA 399 L + A+ A ++ET+R P + R A DL + + +P Sbjct: 282 LAADGSRAS------------------AVIEETMRYDPPVQLVSRYAGDDLTIGTHTVPK 323 Query: 400 GTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAE 459 G + + L + R+P + P+R++P R H+ FG G CLG LA E Sbjct: 324 GDTMLLLLAAAHRDPTIVGAPDRFDPDR--------AQIRHLGFGKGAHFCLGAPLARLE 375 Query: 460 MLLLLHHVLKHLQVETLTQEDIKMVYSFILR 490 + L + L+ E + + LR Sbjct: 376 ATVALPALAARFPEARLSGEP-EYKRNLTLR 405 >5XW2-A nrPDB Length = 419 Score = 165 bits (417), Expect = 4e-41, Method: Composition-based stats. Identities = 52/322 (16%), Positives = 106/322 (32%), Gaps = 35/322 (10%) Query: 167 DFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHA 226 + L+K V + +++P I T E + + L+ + + Sbjct: 100 PDHRELRKLVSHAFTPKVVAELEPRITALTQELLDAVADRDTFDLMTALAYPLPVTVVAE 159 Query: 227 LEVMFKSTV--------QLMFMPRSLSRWTSPKVWKEHFEA-WDCIFQYGDNCIQKIYQE 277 L + + +++ +S +P+ + FEA + + + + + Sbjct: 160 LLSIPSADRHLFEGWMTEIVHSLGDVSMEDAPEDQERIFEAGMAPMRKMLEYLREHAAEC 219 Query: 278 LAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQ 337 R ++ + L+ + I + L TT + T+ L P Sbjct: 220 RRRPRGDLMGKLIEAEVDGRRLTDNHIVNFAKMLLIAGYLTTTMLIGNTVLCLDSYPEQA 279 Query: 338 QALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHI 397 +R + L+ L+E++R R + D+ + + Sbjct: 280 ARVRADR------------------SLIPGLLEESMRFLSPVAATYRATTRDVEVAGQRL 321 Query: 398 PAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAE 457 A +V V+ + R+ F PE ++ R + H+ FG G+ CLG LA Sbjct: 322 SADQMVMVWFGAANRDARQFAEPELFDMTRGPN--------PHLGFGRGIHFCLGGPLAR 373 Query: 458 AEMLLLLHHVLKHLQVETLTQE 479 E + L H+L E Sbjct: 374 MEGRVALDHLLDRFPELYTDPE 395 >3WVS-A nrPDB Length = 401 Score = 164 bits (416), Expect = 6e-41, Method: Composition-based stats. Identities = 57/340 (16%), Positives = 109/340 (32%), Gaps = 40/340 (11%) Query: 164 VARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALF-GERLGLVGHSPSSASLN 222 + L++ + + +++P + + L GE LV Sbjct: 93 MDAPDHTRLRRLISKAFTIRRVEELRPKVHDLAHRLIDDMLAKGEPADLVADYALPIPTT 152 Query: 223 FLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSR 282 + L + + TS +E + Y I A R Sbjct: 153 VICELLGVPFEDREKFGRWTDAILSTSTLNPEEGRVKRMELVGYIGGII-------AARR 205 Query: 283 PQQYTSIVAELLL----NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQ 338 Q +++ ++ +L+ + + + L +TT + ++ L P + Sbjct: 206 AQPADDLISGMIEARDVQDKLTEQELLDHCIGLLIAGHETTASQIPSFVYALLDQPQHWK 265 Query: 339 ALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGL--FLERVASSDLVLQNYH 396 L + L+ +A++E R P+G R A D+ + Sbjct: 266 RL------------------LDDPELIPSAVEELFRFVPLGSGSAAPRYAREDIEVGGTL 307 Query: 397 IPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLA 456 + AG V V L + R+ F PE R + +H+ FG G+ CLG LA Sbjct: 308 VRAGEPVLVALGAANRDGLRFEDPEEIKLDR--------PSNHHIGFGHGIHHCLGAPLA 359 Query: 457 EAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPL 496 E+ L +L+ L + + + P P+ Sbjct: 360 RLELQEALRALLERLPTLKVAGDIAWKSEMMVRGPRSMPV 399 >2Z36-A nrPDB Length = 413 Score = 164 bits (416), Expect = 7e-41, Method: Composition-based stats. Identities = 56/353 (15%), Positives = 119/353 (33%), Gaps = 48/353 (13%) Query: 143 RLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNL 202 + + ++ P++ + A ++ V+ ++P I + Sbjct: 77 LFTLDAATLQQLRSQPPLMLGMDGAEHSAARRPVIGEFTVKRLAALRPRIQDIVDHFIDD 136 Query: 203 ALFGER--LGLVGHSPSSAS-------LNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVW 253 L ++ + LV L + F+S +M S Sbjct: 137 MLATDQRPVDLVQALSLPVPSLVICELLGVPYTDHDFFQSRTTMM---------VSRTSM 187 Query: 254 KEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTA 313 ++ A+ + Y D+ I + E ++ +A L + + + L Sbjct: 188 EDRRRAFAELRAYIDDLITRKESEPGD---DLFSRQIARQRQEGTLDHAGLVSLAFLLLT 244 Query: 314 GSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETL 373 +TT + + + L +P ++ A++E L Sbjct: 245 AGHETTANMISLGVVGLLSHPEQLTVVKANPGR------------------TPMAVEELL 286 Query: 374 RLYPVGLFLE-RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIR 432 R + + + R+A+ D+ + I AG V V + S +PA+F P + +R Sbjct: 287 RYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVERGA--- 343 Query: 433 GSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVY 485 +H+ FGFG QCLG+ LA E+ ++ + + + L + + Sbjct: 344 -----RHHLAFGFGPHQCLGQNLARMELQIVFDTLFRRIPSLRLAVPMEDVPF 391 >4UBS-A nrPDB Length = 393 Score = 164 bits (414), Expect = 1e-40, Method: Composition-based stats. Identities = 77/413 (18%), Positives = 129/413 (31%), Gaps = 66/413 (15%) Query: 77 PIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQH----RGHKCGVFLL 132 P+ R L V V+ + D +L + A + R + + + Sbjct: 27 PLSRVSLYDGRSVWVVTGHAAARALLSDQRLSSDRTLPRFPATTERFEAVRTRRVALLGV 86 Query: 133 NGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSI 192 + PE R R L P + P + A++ + Sbjct: 87 DDPEHRTQRRMLVPS-FTLKRAAALRPRIQETVDGLLDAMEAQGPPAE------------ 133 Query: 193 FHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKV 252 LV + AL + + F R Sbjct: 134 ------------------LVSAFALPLPSMVICALLGVPYADHD--FFESQSRRLLRGPG 173 Query: 253 WKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELT 312 E +A + Y I + +E ++ E L + + + + L Sbjct: 174 IAEVQDARAQLDDYLYALIDRKRKEPGDGLLD---DLIQEQLNRGTVDRAELVSLATLLL 230 Query: 313 AGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKET 372 +TT + + F L R+P LR E L+ AA++E Sbjct: 231 IAGHETTANMISLGTFTLLRHPEQLAELRAEP------------------GLMPAAVEEL 272 Query: 373 LRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIR 432 LR + L RVA+ D+ + I A V + R+ A F P+ + R Sbjct: 273 LRFLSIADGLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALDWHRSA--- 329 Query: 433 GSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVY 485 +HV FGFG+ QCLG+ LA AEM + L + + L L ++ + Sbjct: 330 -----RHHVAFGFGIHQCLGQNLARAEMEIALGTLFERLPGLRLAAPADEIPF 377 >4YT3-A nrPDB Length = 410 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 57/323 (17%), Positives = 103/323 (31%), Gaps = 32/323 (9%) Query: 161 VDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSAS 220 + + + + + +P I E G + +V S Sbjct: 88 ITESDPPDHRKRRSLLAAAFTPRSLQNWEPRIQEIADELIGQMDGGTEIDIVASLASPLP 147 Query: 221 LNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF 280 + + L + L + +E + + Q +Y + Sbjct: 148 IIVMADLMGVPSKDRLLFKKWVDTLFLPFDREKQEEVDKLKQV--AAKEYYQYLYPIVVQ 205 Query: 281 SRPQQYTSIVAELL---LNAEL-SPDAIKANSMELTAGSVDTTVFPLLMTLFELA-RNPN 335 R I+++LL ++ E+ + D + +M + V+TT L + + L + Sbjct: 206 KRLNPADDIISDLLKSEVDGEMFTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYDDKE 265 Query: 336 VQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNY 395 V Q L + L L+ A++E LR + L+R D L Sbjct: 266 VYQELHE------------------NLDLVPQAVEEMLRFRFNLIKLDRTVKEDNDLLGV 307 Query: 396 HIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRL 455 + G V V++ + + +F P N R N H+ FG G CLG L Sbjct: 308 ELKEGDSVVVWMSAANMDEEMFEDPFTLNIHR-------PNNKKHLTFGNGPHFCLGAPL 360 Query: 456 AEAEMLLLLHHVLKHLQVETLTQ 478 A E + L LK + Sbjct: 361 ARLEAKIALTAFLKKFKHIEAVP 383 >3TYW-A nrPDB Length = 417 Score = 163 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 61/340 (17%), Positives = 121/340 (35%), Gaps = 43/340 (12%) Query: 152 NAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGL 211 A RF P ++ +L + + A E L Sbjct: 91 EAGARFRP-FIRTDAPEHTRYRRMLLPAFTVRRV---------RAMRPAVQARVDEILDG 140 Query: 212 VGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTS--PKVWKEHFEAWDCIFQYGDN 269 + + L +A V +L+ +PR + ++ + + + Sbjct: 141 MLAAGGPVDLVSAYANAVSTSVICELLGIPRHDLEFFRDVTRISGSRNSTAEQVSEALGG 200 Query: 270 CIQKIYQELAFSRPQQYTSIVAELLLN----AELSPDAIKANSMELTAGSVDTTVFPLLM 325 + +A R + ++++L+ + ++ + + + +TT + + Sbjct: 201 LFGLLGGLVAERREEPRDDLISKLVTDHLVPGNVTTEQLLSTLGITINAGRETTTSMIAL 260 Query: 326 TLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE-R 384 + L P + LR++ L+ AA+ E LR+ V + R Sbjct: 261 STLLLLDRPELPAELRKDPD------------------LMPAAVDELLRVLSVADSIPLR 302 Query: 385 VASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFG 444 VA+ D+ L +PA V L +P F PER + R + +HV FG Sbjct: 303 VAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHRTDN--------HHVAFG 354 Query: 445 FGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMV 484 +G+ QC+G+ LA E+ + L +L+ + L E ++V Sbjct: 355 YGVHQCVGQHLARLELEVALETLLRRVPTLRLAGERDQVV 394 >4OQS-A nrPDB Length = 433 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 54/321 (16%), Positives = 107/321 (33%), Gaps = 43/321 (13%) Query: 161 VDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSAS 220 + ++ ++ +++P I T + L + + Sbjct: 94 FINMDAPEHTRYRRMLISQFTVRRIKELEPRIVQIT---------EDHLDAMAKAGPPVD 144 Query: 221 LNFLHALEVMFKSTVQLMFMPRSLSRWTSPK--VWKEHFEAWDCIFQYGDNCIQKIYQEL 278 L AL V +L+ + + + + + + D + + I + + Sbjct: 145 LVQAFALPVPSLVICELLGVSYADHAFFQEQTTIMASVDKTQDEVTTALGKLTRYIAELV 204 Query: 279 AFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQ 338 A R ++ L+ + +L+ + + ++ L +TT L + F L ++P Sbjct: 205 ATKRLSPKDDLLGSLITDTDLTDEELTNIALLLLVAGHETTANMLGLGTFALLQHPEQIA 264 Query: 339 ALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE--RVASSDLVLQNYH 396 AL A++E LR + R A D+ L+ Sbjct: 265 ALDS-----------------------PDAVEELLRYLSIVHLGTPNRAALEDVELEGQM 301 Query: 397 IPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLA 456 I G V + L ++ R+P +F P+ R H FG G+ QCLG++LA Sbjct: 302 IRKGDTVAIGLPAVNRDPKVFDEPDILQLDR-------VDARKHAAFGGGIHQCLGQQLA 354 Query: 457 EAEMLLLLHHVLKHLQVETLT 477 EM + + L Sbjct: 355 RVEMRIGFTRLFARFPSLRLA 375 >1Z8P-A nrPDB Length = 404 Score = 162 bits (409), Expect = 4e-40, Method: Composition-based stats. Identities = 60/331 (18%), Positives = 119/331 (35%), Gaps = 40/331 (12%) Query: 167 DFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHA 226 L+K V Q ++P + T E + + +V + + Sbjct: 96 PTHTRLRKLVSQEFTVRRVEAMRPRVEQITAELLDEVGDSGVVDIVDRFAHPLPIKVICE 155 Query: 227 LEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQY 286 L + + RW+S + + A + Q + I + R + Sbjct: 156 LLGVDEKYR------GEFGRWSSEILVMDPERA-EQRGQAAREVVNFILDLVERRRTEPG 208 Query: 287 TSIVAELL-----LNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALR 341 +++ L+ + LS D + + ++ L +++V + + + L +P+ +R Sbjct: 209 DDLLSALIRVQDDDDGRLSADELTSIALVLLLAGFESSVSLIGIGTYLLLTHPDQLALVR 268 Query: 342 QESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGT 401 ++ A L A++E LR R A+ ++ + IP + Sbjct: 269 RDPSA------------------LPNAVEEILRYIAPPETTTRFAAEEVEIGGVAIPQYS 310 Query: 402 LVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEML 461 V V + R+P FP P R++ R H+ FG G+ C+GR LA+ E Sbjct: 311 TVLVANGAANRDPKQFPDPHRFDVTR--------DTRGHLSFGQGIHFCMGRPLAKLEGE 362 Query: 462 LLLHHVLKHLQVETL--TQEDIKMVYSFILR 490 + L + +L +D+ S +LR Sbjct: 363 VALRALFGRFPALSLGIDADDVVWRRSLLLR 393 >2FR7-A nrPDB Length = 412 Score = 161 bits (408), Expect = 5e-40, Method: Composition-based stats. Identities = 63/382 (16%), Positives = 128/382 (33%), Gaps = 33/382 (8%) Query: 111 MSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQ 170 + L+ W Y + +LN P + + R ++ Sbjct: 50 VYLDKWNVYG-VARYAEVYAVLNDPLTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHT 108 Query: 171 ALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALF-GERLGLVGHSPSSASLN-FLHALE 228 + + + + ++ + L G + + + L+ F A+ Sbjct: 109 RTRAVLSKVLSPATMKRLRDGFAAAADAKIDELLARGGNIDAIADLAEAYPLSVFPDAMG 168 Query: 229 VMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTS 288 + + L+ + P E ++ + + Q + P + + Sbjct: 169 LKQEGRENLLPYAGLVFNAFGP--PNELRQSAIERSAPHQAYVAEQCQRPNLA-PGGFGA 225 Query: 289 IVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAA 348 + E++P+ L + +DTTV + ++ LAR P+ LR + Sbjct: 226 CIHAFSDTGEITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRADP---- 281 Query: 349 ASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLY 408 L R A +E +R R + D+ L I G V +FL Sbjct: 282 --------------SLARNAFEEAVRFESPVQTFFRTTTRDVELAGATIGEGEKVLMFLG 327 Query: 409 SLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVL 468 S R+P + P+RY+ R + HV FG G+ C+G+ +A E ++L + Sbjct: 328 SANRDPRRWDDPDRYDITR--------KTSGHVGFGSGVHMCVGQLVARLEGEVVLAALA 379 Query: 469 KHLQVETLTQEDIKMVYSFILR 490 + + + +K ++ LR Sbjct: 380 RKVAAIEIAG-PLKRRFNNTLR 400 >4OQR-A nrPDB Length = 457 Score = 161 bits (407), Expect = 7e-40, Method: Composition-based stats. Identities = 53/321 (16%), Positives = 106/321 (33%), Gaps = 43/321 (13%) Query: 161 VDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSAS 220 + ++ ++ +++P I T + L + + Sbjct: 133 FTNMDAPEHTRYRRMLISQFTVRRIKELEPRIVRIT---------EDHLDAMAKAGPPVD 183 Query: 221 LNFLHALEVMFKSTVQLMFMPRSLSRWTSPK--VWKEHFEAWDCIFQYGDNCIQKIYQEL 278 L AL V +L+ + + + + + + D + + I + + Sbjct: 184 LVQAFALPVPSLVICELLGVSYADHAFFQEQTTIMVSVDKTQDEVTTALGKLTRYIAELV 243 Query: 279 AFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQ 338 A R ++ L+ + +L+ + + ++ L +TT L + F L ++P Sbjct: 244 ATKRLSPKDDLLGSLITDTDLTDEELTNIALILLVAGHETTANMLGLGTFALLQHPEQIA 303 Query: 339 ALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE--RVASSDLVLQNYH 396 L A++E LR + R A D+ L+ Sbjct: 304 NLDS-----------------------PDAVEELLRYLSIVHLGTPNRAALEDVELEGQM 340 Query: 397 IPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLA 456 I G V + L ++ R+P +F P+ R H FG G+ QCLG++LA Sbjct: 341 IRKGDTVAIGLPAVNRDPKVFDEPDILQLDR-------VDARKHAAFGGGIHQCLGQQLA 393 Query: 457 EAEMLLLLHHVLKHLQVETLT 477 EM + + L Sbjct: 394 RVEMRIGFTRLFARFPSLRLA 414 >3TKT-A nrPDB Length = 450 Score = 161 bits (406), Expect = 8e-40, Method: Composition-based stats. Identities = 65/352 (18%), Positives = 121/352 (34%), Gaps = 38/352 (10%) Query: 157 FLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLAL-FGERLGLVGHS 215 + + + L++ + I EA + L GE + Sbjct: 120 LVESLVQMDAPKHPKLRRLTQDWFMPKNLARLDGEIRKIANEAIDRMLGAGEEGDFMALV 179 Query: 216 PSSASLNFLHALEVMFKSTVQ-LMFMPRSLSRWTSPKVWKEHF-----EAWDCIFQYGDN 269 + L+ + + + ++F+ + + + K E I Sbjct: 180 AAPYPLHVVMQILGVPPEDEPKMLFLTQQMFGGQDEDMNKSGLKDLPPEQISQIVAGAVA 239 Query: 270 CIQKIYQELAFSRPQQYTSIVAELLLNA-----ELSPDAIKANSMELTAGSVDTTVFPLL 324 ++ + LA R + T VA ++ NA +S + + DTT Sbjct: 240 EFERYFAGLAAERRRNPTDDVATVIANAVVDGEPMSDRDTAGYYIITASAGHDTTSASSA 299 Query: 325 MTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLER 384 LAR+P++ ++ + LL ++E +R R Sbjct: 300 GAALALARDPDLFARVKADRN------------------LLPGIVEEAIRWTTPVQHFMR 341 Query: 385 VASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFG 444 A++D L I AG + + + +PA FP P +++P R + H+ FG Sbjct: 342 TAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTRPAN--------RHLAFG 393 Query: 445 FGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPL 496 G QCLG LA EM +LL +L + L E ++ +F+ P+ Sbjct: 394 AGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEPKRVNSTFVGGFKSLPM 445 >3P3Z-A nrPDB Length = 416 Score = 161 bits (406), Expect = 8e-40, Method: Composition-based stats. Identities = 61/361 (16%), Positives = 113/361 (31%), Gaps = 38/361 (10%) Query: 144 LNPEVLSPNAVQR--FLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASN 201 L V +P R + + ++ + L+ VQP + + + Sbjct: 81 LVDMVGTPEGPVRDFMVDFLQSLDGADHRRLRGLATHPFTPRRITAVQPFVRSTVEQLID 140 Query: 202 LALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMF-----MPRSLSRWTSPKVWKEH 256 G+ V H P + L + L+ + + Sbjct: 141 KLPQGD-FDFVQHFPHPLPALVMCQLLGFPLEDYDTVGRLSIETNLGLALSNDQDILVKV 199 Query: 257 FEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSV 316 + +F Y I+K E TS + + L ++ + Sbjct: 200 EQGLGRMFDYLVAAIEKRKVEP----GDDLTSDIVRAFHDGVLDDYELRTLVATVLVAGY 255 Query: 317 DTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLY 376 +TT L + +++ A++P+ +++ L A++E LR Sbjct: 256 ETTNHQLALAMYDFAQHPDQWMKIKE------------------NPELAPQAVEEVLRWS 297 Query: 377 PVGLFL-ERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSG 435 P RVA+ D + IP GT V + + R+P +F +R++ Sbjct: 298 PTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFADADRFDIT-------VK 350 Query: 436 RNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFP 495 R + FG G CLG LA E+ + + L + E + P P Sbjct: 351 REAPSIAFGGGPHFCLGTALARLELTEAVAALATRLDPPQIAGEITWRHELGVAGPDALP 410 Query: 496 L 496 L Sbjct: 411 L 411 >2RFC-A nrPDB Length = 343 Score = 160 bits (404), Expect = 2e-39, Method: Composition-based stats. Identities = 77/412 (18%), Positives = 136/412 (33%), Gaps = 92/412 (22%) Query: 90 CVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFL--LNGPEWRFNRLRLNPE 147 V DV+ + D + + G+ ++ PE + R P Sbjct: 14 HVYKYSDVKHVLMNDKIFSSNP--------GNRYSNAGGISFITMDNPEHKEFRDISAP- 64 Query: 148 VLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGE 207 FLP +DF + +++N +D + I Y + Sbjct: 65 --------YFLPSKINDYKDFIEETSNDLIKN------IDNKDIISEYAV---------- 100 Query: 208 RLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHF--EAWDCIFQ 265 +N + + + S + L K+W ++ D F Sbjct: 101 ----------RLPVNIISKILGIPDSDMPLF------------KLWSDYIIGNKRDENFN 138 Query: 266 YGDNCIQKIYQELAFSRPQQYTSIVA-ELLLNAELSPDAIKANSMELTAGSVDTTVFPLL 324 Y +N + E+ S +++A L N +L+ D M L G +TT + Sbjct: 139 YVNNRMVSRLLEIFKSDSHGIINVLAGSSLKNRKLTMDEKIKYIMLLIIGGNETTTNLIG 198 Query: 325 MTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE- 383 + + NP++ L ++ETLR Y FL Sbjct: 199 NMIRVIDENPDI---------------------IDDALKNRSGFVEETLRYYSPIQFLPH 237 Query: 384 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF 443 R A+ D + N I G V V+L S R+ F P+ + R H+ F Sbjct: 238 RFAAEDSYINNKKIKKGDQVIVYLGSANRDETFFDEPDLFKIGR---------REMHLAF 288 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYS-FILRPSMF 494 G G+ CLG LA E + L+ +L H + + + +++ + +L Sbjct: 289 GIGIHMCLGAPLARLEASIALNDILNHFKRIKIDYKKSRLLDNKMVLGYDKL 340 >3ABA-A nrPDB Length = 403 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 72/410 (17%), Positives = 138/410 (33%), Gaps = 67/410 (16%) Query: 85 GAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKC--GVFLLNGPEWRFNRL 142 G V E+V L + DS ++ + + PE +R Sbjct: 42 GHEAWLVTGYEEVRALLR-DSSFSVQVPHALHTQDGVVTQKPGRGSLLWQDEPEHTSDRK 100 Query: 143 RLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNL 202 L E + +Q P + + + A++ + +D+ + + Sbjct: 101 LLAKE-FTVRRMQALRPNIQRIVDEHLDAIEAR-------GGPVDLVKTFANAVPSMVIS 152 Query: 203 ALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDC 262 LFG P F E M +V ++ Sbjct: 153 DLFG--------VPVERRAEFQDIAEAMM-------------------RVDQDAAATEAA 185 Query: 263 IFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFP 322 + G Q + + A ++++ + + + + L + DTT Sbjct: 186 GMRLGGLLYQLVQERRANPGDDLISALITTEDPDGVVDDMFLMNAAGTLLIAAHDTTACM 245 Query: 323 LLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFL 382 + + L +P+ LR++ L+ A++E LR +G F Sbjct: 246 IGLGTALLLDSPDQLALLREDP------------------SLVGNAVEELLRYLTIGQFG 287 Query: 383 -ERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHV 441 ERVA+ D+ L I G V + + +PA PER++ R R H+ Sbjct: 288 GERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITR--------RPAPHL 339 Query: 442 PFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQ--EDIKMVYSFIL 489 FGFG QC+G++LA E+ ++ + + L L + E+++ + + Sbjct: 340 AFGFGAHQCIGQQLARIELQIVFETLFRRLPGLRLAKPVEELRFRHDMVF 389 >5IT1-A nrPDB Length = 399 Score = 159 bits (403), Expect = 2e-39, Method: Composition-based stats. Identities = 55/323 (17%), Positives = 109/323 (33%), Gaps = 32/323 (9%) Query: 165 ARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA-LFGERLGLVGHSPSSASLNF 223 +K + + ++P+I E + G + LV + Sbjct: 91 DAPEHTDDRKLLAKEFTVRRMQALRPNIQRIVDEHLDAIEARGGPVDLVKTFANPVPSMV 150 Query: 224 LHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRP 283 + L + +V ++ + G Q + + A Sbjct: 151 ISDLFGVPAERRAEFQEIAE----AMMRVDQDAAATEAAGMRLGGLLYQLVQERRANPGD 206 Query: 284 QQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE 343 ++++ + + + + L + DTT + + L P+ L+++ Sbjct: 207 DLISALITTEDPDGVIDDMFLMNAAGTLLIAAHDTTACMIGLGTALLLDRPDQLALLQKD 266 Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLF-LERVASSDLVLQNYHIPAGTL 402 L+ A++E LR +G F ERVA+ D + I G Sbjct: 267 P------------------SLIGNAVEELLRYLTIGQFGAERVATQDGEIGGVRIAKGEQ 308 Query: 403 VRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLL 462 V L S +PA PER++ R R H+ FGFG QC+G++LA E+ + Sbjct: 309 VVTHLLSADFDPAFVEDPERFDITR--------RPAPHLAFGFGAHQCIGQQLARIELQI 360 Query: 463 LLHHVLKHLQVETLTQEDIKMVY 485 + + + L + ++ + Sbjct: 361 VFGTLFRRFPTLRLAKPVEELRF 383 >5EX6-C nrPDB Length = 434 Score = 159 bits (402), Expect = 3e-39, Method: Composition-based stats. Identities = 64/346 (18%), Positives = 110/346 (31%), Gaps = 43/346 (12%) Query: 148 VLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGE 207 V P + L D L++ + + P I + E Sbjct: 114 VFRPRELVGNLMDYDP---PEHTRLRRLLAPGFTHRKIRRMAPYIEQ---------IVTE 161 Query: 208 RLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSP--KVWKEHFEAWDCIFQ 265 RL + S A L L A EV +L+ +PR + + Sbjct: 162 RLDEMEREGSPADLIELFADEVPGPVLCELLGVPRDDRAMFLQLCHRHLDASLSGRRRAA 221 Query: 266 YGDNCIQKIYQELAFSRPQQYTSIVAELLLN--AELSPDAIKANSMELTAGSVDTTVFPL 323 G+ + + +A R ++ ++ ++ + ++ +++ D + Sbjct: 222 AGEAFSRYLVTMVARERKDPGDGLIGMVVAEHGDTVTDEELRGVCVQMMLAGDDNISGMI 281 Query: 324 LMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVG-LFL 382 + + L RNP ALR + P A+ E +R V Sbjct: 282 GLGVLALLRNPEQIAALRGDV------------------PAAERAVDELIRYLTVPYAPT 323 Query: 383 ERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVP 442 R A D + + I AG V L + R+PAL P +R + R HV Sbjct: 324 PRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDADRLDVTR--------EAVPHVA 375 Query: 443 FGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFI 488 FG G+ CLG LA E+ + + + L D + Sbjct: 376 FGHGVHHCLGAALARLELRIAYTALWRRFPDLRLADPDGATEFRLS 421 >1LG9-A nrPDB Length = 398 Score = 159 bits (401), Expect = 3e-39, Method: Composition-based stats. Identities = 60/358 (16%), Positives = 112/358 (31%), Gaps = 43/358 (12%) Query: 136 EWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHY 195 W + P + L D L++K+ + P I Sbjct: 66 RWDPRDEIGGKGIFRPRELVGNLMDYDP---PEHTRLRRKLTPGFTLRKMQRMAPYIEQ- 121 Query: 196 TIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSP--KVW 253 + +RL + + S A L A +V +L+ +PR Sbjct: 122 --------IVNDRLDEMERAGSPADLIAFVADKVPGAVLCELVGVPRDDRDMFMKLCHGH 173 Query: 254 KEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLN--AELSPDAIKANSMEL 311 + + GD + + +A R + ++ ++ + + + ++ +++ Sbjct: 174 LDASLSQKRRAALGDKFSRYLLAMIARERKEPGEGMIGAVVAEYGDDATDEELRGFCVQV 233 Query: 312 TAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKE 371 D + + + + R+P A R + +A A+ E Sbjct: 234 MLAGDDNISGMIGLGVLAMLRHPEQIDAFRGDEQSAQR------------------AVDE 275 Query: 372 TLRLYPVG-LFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLD 430 +R V R+A DL L I G V L + R+PAL P +R + R Sbjct: 276 LIRYLTVPYSPTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLDVTR--- 332 Query: 431 IRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFI 488 HV FG G+ CLG LA E+ + + + L + Sbjct: 333 -----EPIPHVAFGHGVHHCLGAALARLELRTVFTELWRRFPALRLADPAQDTEFRLT 385 >5XNT-A nrPDB Length = 411 Score = 159 bits (401), Expect = 4e-39, Method: Composition-based stats. Identities = 63/358 (17%), Positives = 115/358 (32%), Gaps = 64/358 (17%) Query: 126 KCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLT 185 K + + PE R R L +P ++Q + P + +A + + + ++ Sbjct: 85 KIKITEADPPEHRKRRSLLAA-AFTPRSLQNWEPRIQEIADELIEEMDEET--------- 134 Query: 186 LDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLS 245 + +V S + + L + L + Sbjct: 135 ----------------------EIDIVQSLASPLPIIVMSDLMGVPSKDRLLFKKWVDIL 172 Query: 246 RWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELL---LNAEL-SP 301 K +E + Q +Y + R I+++LL ++ E+ + Sbjct: 173 FLPFDKEKQEEVNELKQV--AAKEYYQYLYPIVVQKRLNPADDIISDLLKAEVDGEMFTD 230 Query: 302 DAIKANSMELTAGSVDTTVFPLLMTLFELA-RNPNVQQALRQESLAAAASISEHPQKATT 360 D + +M + V+TT L + + L + V Q L + Sbjct: 231 DEVVRTTMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHE------------------ 272 Query: 361 ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP 420 L L+ A++E LR + L+R D L + G V V++ + + +F Sbjct: 273 NLDLVPQAVEEMLRYRFNLIKLDRTVKEDNDLLGVELKEGENVVVWMSAANLDEEMFEDA 332 Query: 421 ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQ 478 N R N H+ FG G CLG LA E + L LK + Sbjct: 333 FTLNIHR-------PNNKKHLTFGNGPHFCLGAPLARLEAKIALTTFLKKFKHIEAVP 383 >6FSH-A nrPDB Length = 398 Score = 156 bits (394), Expect = 2e-38, Method: Composition-based stats. Identities = 51/284 (17%), Positives = 97/284 (34%), Gaps = 31/284 (10%) Query: 207 ERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSP--KVWKEHFEAWDCIF 264 +RL + + A L L A EV +L+ +PR + + Sbjct: 125 DRLDAMEQAGPPADLIELFADEVPGAVLCELIGVPRDDRDMFMKLCHGHLDASLSQKRRA 184 Query: 265 QYGDNCIQKIYQELAFSRPQQYTSIVAELLLN--AELSPDAIKANSMELTAGSVDTTVFP 322 GD + + +A R + ++ ++ + ++ ++L D Sbjct: 185 ALGDKFSRYLLAMIARERKDPGDGFIGSIVAEHGDTITDEELRGVCVQLMLAGDDNVSGM 244 Query: 323 LLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVG-LF 381 + + + L R+P ALR + +A A+ E +R V Sbjct: 245 IGLGVLALLRHPEQIAALRGDDQSA------------------DRAVDELIRYLTVPYAP 286 Query: 382 LERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHV 441 R A D+++ + I G V L R+ AL P +R + R HV Sbjct: 287 TPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTR--------TPVPHV 338 Query: 442 PFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVY 485 FG G+ CLG L ++ + + + L ++++ Sbjct: 339 AFGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPAQEIMF 382 >4DO1-A nrPDB Length = 410 Score = 156 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 45/214 (21%), Positives = 81/214 (37%), Gaps = 26/214 (12%) Query: 283 PQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQ 342 P + + + E++PD L + +DTTV + ++ LAR P Q LR Sbjct: 218 PGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRS 277 Query: 343 ESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTL 402 + L R A +E +R R + ++ L I G Sbjct: 278 DPT------------------LARNAFEEAVRFESPVQTFFRTTTREVELGGAVIGEGEK 319 Query: 403 VRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLL 462 V +FL S R+P + P+ Y+ R + HV FG G+ C+G+ +A E + Sbjct: 320 VLMFLGSANRDPRRWSDPDLYDITR--------KTSGHVGFGSGVHMCVGQLVARLEGEV 371 Query: 463 LLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPL 496 +L + + + + + + + P+ Sbjct: 372 MLSALARKVAAIDIDGPVKRRFNNTLRGLESLPV 405 >3NC3-A nrPDB Length = 441 Score = 155 bits (391), Expect = 4e-38, Method: Composition-based stats. Identities = 60/402 (14%), Positives = 127/402 (31%), Gaps = 63/402 (15%) Query: 85 GAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRL 144 + DV + Q + + +E R + V + + R+ Sbjct: 73 SIDSYFISRYHDVRYILQHPDIFTTKSLVE-----RAEPVMRGPVLAQMHGKEHSAKRRI 127 Query: 145 NPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLAL 204 +A+ P++ A + ++ + + ++ Sbjct: 128 VVRSFIGDALDHLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCV------TMDMLG 181 Query: 205 FGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIF 264 +R S +F+ ++ ++ ++ LS++ P Sbjct: 182 LDKRDHEKISEWHSGVADFITSISQSPEARAHSLWCSEQLSQYLMP-------------- 227 Query: 265 QYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAE-----LSPDAIKANSMELTAGSVDTT 319 + R S + +L +E LS I A + + + + Sbjct: 228 -------------VIKERRVNPGSDLISILCTSEYEGMALSDKDILALILNVLLAATEPA 274 Query: 320 VFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVG 379 L + ++ L NP + L+ A+ ETLR P Sbjct: 275 DKTLALMIYHLLNNPEQMN------------------DVLADRSLVPRAIAETLRYKPPV 316 Query: 380 LFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRN-- 437 + R S D V+ I T+V + + R+P F +P+ +N R S + Sbjct: 317 QLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIKSAFSGA 376 Query: 438 FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQE 479 H+ FG G+ C+G A+ E+ ++ + VL ++ L ++ Sbjct: 377 ARHLAFGSGIHNCVGTAFAKNEIEIVANIVLDKMRNIRLEED 418 >5Z9I-A nrPDB Length = 398 Score = 154 bits (390), Expect = 6e-38, Method: Composition-based stats. Identities = 65/392 (16%), Positives = 133/392 (33%), Gaps = 43/392 (10%) Query: 120 RQHRGHKCGVFLLNGPE-WRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQ 178 G+ +L+ P+ + + +RL+P L V+ D + L+ V Sbjct: 36 WNVYGYPESAAILSNPKVFSSDTMRLDPIKLDEAIVEGDFAHTDP---PKHRRLRGLVDH 92 Query: 179 NARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLM 238 SL ++ + E + + LV + L + L + +S L Sbjct: 93 AFTPSLVAKMESRVHGIIHELLDGVEGKSQFDLVAEFAAPLPLIMISDLLGVPESDRALF 152 Query: 239 -----FMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAEL 293 M ++ SP+ E ++ + E A ++ + Sbjct: 153 RQWMDKMLDGSEKFESPET-VLEQEEELHKELELLWEMRDYWHERAAESRKRPREDLISQ 211 Query: 294 LLNAELSPDAIKANSME-----LTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAA 348 L++AE+ + + + L TT + T+ L + +R + Sbjct: 212 LVHAEVDGQKLNDSQISNIANRLLVNGHLTTAMLIANTMLCLDAFSDQDARVRADR---- 267 Query: 349 ASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLY 408 L+ A L+E++R + R +S++ + IP L+ V+ Sbjct: 268 --------------SLVPALLEESMRYMSPICGVGRATNSEVEVAGTVIPKDQLLLVWTG 313 Query: 409 SLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVL 468 + R+ F +P+ ++ R + H+ FG G+ CLGR+LA E + +L Sbjct: 314 AANRDERQFEKPDVFDAGRSPN--------AHLGFGRGIHFCLGRQLARMESKAAVEILL 365 Query: 469 KHLQVETLTQEDIKMVYSFIL--RPSMFPLLT 498 L + + + P++T Sbjct: 366 DRLPTLRADPANPPTFLQVVDASGVATLPVVT 397 >3A1L-A nrPDB Length = 425 Score = 154 bits (388), Expect = 9e-38, Method: Composition-based stats. Identities = 61/309 (19%), Positives = 109/309 (35%), Gaps = 29/309 (9%) Query: 167 DFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHA 226 L+ + S+ ++P I + R LV + + + A Sbjct: 104 PHHTELRSLLTTEFSPSIVTGLRPRIAELASALLDRLRAQRRPDLVEGFAAPLPILVISA 163 Query: 227 LEVMF---KSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRP 283 L + + ++ + + T + + + A ++ +++ + R Sbjct: 164 LLGIPEEDHTWLRANAVALQEASTTRARDGRGYARAEAASQEFTRYFRREVDRRGGDDRD 223 Query: 284 QQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE 343 T +V + LS D I + L +TT L + L + +V LR Sbjct: 224 DLLTLLVRARDTGSPLSVDGIVGTCVHLLTAGHETTTNFLAKAVLTLRAHRDVLDELRTT 283 Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLV 403 + AA++E +R P + R A D+ L ++ IP G+ V Sbjct: 284 PES------------------TPAAVEELMRYDPPVQAVTRWAYEDIRLGDHDIPRGSRV 325 Query: 404 RVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLL 463 L S R+PA FP P+ + R + V FG G+ CLG LA AE + Sbjct: 326 VALLGSANRDPARFPDPDVLDVHRAAE--------RQVGFGLGIHYCLGATLARAEAEIG 377 Query: 464 LHHVLKHLQ 472 L +L + Sbjct: 378 LRALLDGIP 386 >1EHE-A nrPDB Length = 403 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 59/418 (14%), Positives = 122/418 (29%), Gaps = 59/418 (14%) Query: 77 PIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPH---RMSLEPWVAYRQHRGHKCGVFLLN 133 P+ + L + ++ R A + F+ Sbjct: 30 PVSQVKLFDGSLAWLVTKHKDVCFVATSEKLSKVRTRQGFPELSASGKQAAKAKPTFVDM 89 Query: 134 GPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIF 193 P ++ + +P AV+ P + D + +K+K N L + + Sbjct: 90 DPPEHMHQRSMVEPTFTPEAVKNLQPYIQRTVDDLLEQMKQKGCANGPVDLVKEFALPVP 149 Query: 194 HYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVW 253 Y I F + LE + + Sbjct: 150 SYIIYTLLGVPFND-------------------LEYLTQQN------------AIRTNGS 178 Query: 254 KEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTA 313 EA + D + Q L + + + E + + + L Sbjct: 179 STAREASAANQELLDYLAILVEQRLVEPKDDIISKLCTEQVKPGNIDKSDAVQIAFLLLV 238 Query: 314 GSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETL 373 T V + + + LA++P+ L L ++E Sbjct: 239 AGNATMVNMIALGVATLAQHPDQLAQL------------------KANPSLAPQFVEELC 280 Query: 374 RLYPV-GLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIR 432 R + L ++R A D+++ + + A + S R+ +F P+ +N R + Sbjct: 281 RYHTASALAIKRTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNRKWPPQ 340 Query: 433 GSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILR 490 + FGFG +C+ LA+AE+ + + + + K+ Y+ + R Sbjct: 341 DP------LGFGFGDHRCIAEHLAKAELTTVFSTLYQKFPDLKVAVPLGKINYTPLNR 392 >4TX3-A nrPDB Length = 404 Score = 152 bits (383), Expect = 4e-37, Method: Composition-based stats. Identities = 50/284 (17%), Positives = 97/284 (34%), Gaps = 31/284 (10%) Query: 207 ERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSP--KVWKEHFEAWDCIF 264 +RL + + A L L A EV +L+ +PR + + Sbjct: 131 DRLDAMEQAGPPADLIELFADEVPGAVLCELIGVPRDDQAMFLQLCHRHLDASLSARKRA 190 Query: 265 QYGDNCIQKIYQELAFSRPQQYTSIVAELLLN--AELSPDAIKANSMELTAGSVDTTVFP 322 G+ + + +A R + ++ ++ + ++ ++L D Sbjct: 191 AAGEAFARYLVAMMARERKDPGDGFIGSIVAEHGDTITDEELRGVCVQLMLAGDDNVSGM 250 Query: 323 LLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVG-LF 381 + + + L R+P ALR + +A A+ E +R V Sbjct: 251 IGLGVLALLRHPEQIAALRGDDQSA------------------DRAVDELIRYLTVPYAP 292 Query: 382 LERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHV 441 R A D+++ + I G V L R+ AL P +R + R HV Sbjct: 293 TPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTR--------TPVPHV 344 Query: 442 PFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVY 485 FG G+ CLG L ++ + + + L ++++ Sbjct: 345 AFGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPAQEIMF 388 >1F4U-A nrPDB Length = 368 Score = 152 bits (383), Expect = 4e-37, Method: Composition-based stats. Identities = 71/379 (18%), Positives = 132/379 (34%), Gaps = 53/379 (13%) Query: 133 NGPEWRFNRLRLNPEVLSP-NAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLD--VQ 189 +G W+ R EVL+ + L D + + LT D + Sbjct: 17 DGNIWQVFSYRYTKEVLNNFSKFSSDLTGYHERLEDLRNGKIRFDIPTRYTMLTSDPPLH 76 Query: 190 PSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTS 249 + + + + ++L + + + L +++ V+ + +P + + Sbjct: 77 DELRSMSADIFSP----QKLQTLETFIRETTRSLLDSIDPREDDIVKKLAVPLPIIVISK 132 Query: 250 ----PKVWKEHFEAWD--CIFQYGDN----CIQKIYQELAF--SRPQQYTSIVAELLLNA 297 P KE F+ W F+ G + K Y EL + V ++N+ Sbjct: 133 ILGLPIEDKEKFKEWSDLVAFRLGKPGEIFELGKKYLELIGYVKDHLNSGTEVVSRVVNS 192 Query: 298 ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQK 357 LS + L +TT + ++ + R N+ Q +R+E+L Sbjct: 193 NLSDIEKLGYIILLLIAGNETTTNLISNSVIDFTRF-NLWQRIREENLYLK--------- 242 Query: 358 ATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALF 417 A++E LR P + R + L + I G VRV++ S R+ +F Sbjct: 243 ----------AIEEALRYSPPVMRTVRKTKERVKLGDQTIEEGEYVRVWIASANRDEEVF 292 Query: 418 PRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL------ 471 E++ P R + H+ FG G+ CLG LA E + + K Sbjct: 293 HDGEKFIPDRNPN--------PHLSFGSGIHLCLGAPLARLEARIAIEEFSKRFRHIEIL 344 Query: 472 QVETLTQEDIKMVYSFILR 490 E + E + ++R Sbjct: 345 DTEKVPNEVLNGYKRLVVR 363 >5DE9-A nrPDB Length = 410 Score = 152 bits (383), Expect = 4e-37, Method: Composition-based stats. Identities = 75/372 (20%), Positives = 119/372 (31%), Gaps = 50/372 (13%) Query: 138 RFNRLRLNPEVLSPNAVQRFLPMVDAV---ARDFSQALKKKVLQNARGSLTLDVQPSIFH 194 RF R + ++ A F P AV L++ V V+ Sbjct: 68 RFGREAVMDRQVTRLA-PHFRPARGAVGFLDPPDHTRLRRSVAAAFTARGVERVRERSRG 126 Query: 195 YTIEASNLAL-FGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVW 253 E + L G L S + + L + + M WT + Sbjct: 127 MLDELVDAMLRAGPPADLTEAVLSPFPIAVICELMGVPATDRHSM------HTWTQLILS 180 Query: 254 KEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLL----NAELSPDAIKANSM 309 H + + N + + +L R V LL E++ ++ Sbjct: 181 SSH---GAEVSERAKNEMNAYFSDLIGLRSDSAGEDVTSLLGAAVGRDEITLSEAVGLAV 237 Query: 310 ELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAAL 369 L G + L P + + LR E + A+ Sbjct: 238 LLQIGG-EAVTNNSGQMFHLLLSRPELAERLRSEPE------------------IRPRAI 278 Query: 370 KETLRLYP--VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQR 427 E LR P + L R+A D+ ++ I AG V V + R+P +FP P+R + +R Sbjct: 279 DELLRWIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFER 338 Query: 428 WLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVY-- 485 + HV FGFG C G LA E LL+ VL + L + + Sbjct: 339 SPN--------PHVSFGFGPHYCPGGMLARLESELLVDAVLDRVPGLKLAVAPEDVPFKK 390 Query: 486 -SFILRPSMFPL 496 + I P P+ Sbjct: 391 GALIRGPEALPV 402 >3IVY-A nrPDB Length = 433 Score = 152 bits (383), Expect = 4e-37, Method: Composition-based stats. Identities = 48/350 (13%), Positives = 102/350 (29%), Gaps = 46/350 (13%) Query: 146 PEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALF 205 ++ ++ ++ + L+K + + + + + + A Sbjct: 101 KNDIAREDIEVQRFVMLNMDAPHHTRLRKIISRGFTPRAVGRLHDELQERAQKIAAEAAA 160 Query: 206 GERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQ 265 V L + L + + L W++ E E + Sbjct: 161 AGSGDFVEQVSCELPLQAIAGLLGVPQEDR------GKLFHWSNEMTGNEDPEYAHIDPK 214 Query: 266 YGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKAN-----SMELTAGSVDTTV 320 + ++A + + + L+ A++ + + + + L +TT Sbjct: 215 ASSAELIGYAMKMAEEKAKNPADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTR 274 Query: 321 FPLLMTLFELARNPNVQQ---ALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYP 377 + + A +P+ + +R E A E +R Sbjct: 275 NSITQGMMAFAEHPDQWELYKKVRPE-----------------------TAADEIVRWAT 311 Query: 378 VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRN 437 +R A D L I G V +F S + +F P +N R + Sbjct: 312 PVTAFQRTALRDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILRNPN------- 364 Query: 438 FYHVPFGF-GMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYS 486 HV FG G C+G LA + L+ + V H+ ++ Sbjct: 365 -PHVGFGGTGAHYCIGANLARMTINLIFNAVADHMPDLKPISAPERLRSG 413 >5NWS-A nrPDB Length = 435 Score = 151 bits (381), Expect = 6e-37, Method: Composition-based stats. Identities = 63/351 (17%), Positives = 111/351 (31%), Gaps = 35/351 (9%) Query: 141 RLRLNPEVLSPNAVQ-RFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEA 199 R + + P ++ L + L++ V + L ++P I Sbjct: 94 REGMMDLLNVPEPLRVYLLGSILDSDPPDHPRLRRLVTRAFAARRILGLRPGIERIADRL 153 Query: 200 SNLALFGER----LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKE 255 E + L+ H S+ + L + + ++ W V Sbjct: 154 LAELPRREEEDGTVDLLEHFAYPLSITVICELVGIPATDLE------RWREWGGDLVSMR 207 Query: 256 HFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNA-ELSPDAIKANSMELTAG 314 D C + I Q A + ++ + LS + L Sbjct: 208 PERLRHSFPVMIDYCHRLIEQRRAALTDDLLSELIRAQDDDGGRLSDIETVTMILTLVLA 267 Query: 315 SVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLR 374 +T+ + L +P LR++ LL A+ E +R Sbjct: 268 GHETSAHLIGNGTAALLTHPGQWALLRKDPA------------------LLPRAVHELMR 309 Query: 375 L-YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRG 433 V + R A+ DL L + G V++ L S +P + P+R + R Sbjct: 310 WCGSVHVARLRYATEDLELAGTPVARGDAVQLVLVSANFDPRHYSDPDRLDITR----HQ 365 Query: 434 SGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMV 484 G+ HV FG G+ CLG LA E + L +L+ L D ++ Sbjct: 366 EGQAENHVGFGHGIHYCLGATLARQEGEVALARLLETYPDLALADGDPEVR 416 >1ODO-A nrPDB Length = 408 Score = 151 bits (381), Expect = 6e-37, Method: Composition-based stats. Identities = 70/431 (16%), Positives = 135/431 (31%), Gaps = 60/431 (13%) Query: 65 HLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRG 124 H H+T +E GP D+ G V P +++L + + + W A+ + G Sbjct: 17 HHTEHRTLREGGPATWVDVLGVQAWSVSDPVLLKQLLTSSDV--SKDARAHWPAFGEVVG 74 Query: 125 HKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSL 184 W P A+ + + + L++ V Sbjct: 75 -----------TW-------------PLALWVAVENMFTAYGPNHRKLRRLVAPAFSARR 110 Query: 185 TLDVQPSIFHYT---IEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMP 241 ++P++ ++ GE + L + + L + + F Sbjct: 111 VDAMRPAVEAMVTGLVDRLAELPAGEPVDLRQELAYPLPIAVIGHLMGVPQDRRD-GFRA 169 Query: 242 RSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSP 301 + + E +++ D I + + LSP Sbjct: 170 LVDGVFDTTLDQAEAQANTARLYEVLDQLIAAKRATPGDDMTSLLIAARDDEGDGDRLSP 229 Query: 302 DAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTE 361 + ++ + + + +TTV + + L P+ +R+ + A Sbjct: 230 EELRDTLLLMISAGYETTVNVIDQAVHTLLTRPDQLALVRKGEVTWAD------------ 277 Query: 362 LPLLRAALKETLRLYPVGLFLE-RVASSDLVL-QNYHIPAGTLVRVFLYSLGRNPALFPR 419 ++ETLR P L R A +D+ L I G + + R+P Sbjct: 278 ------VVEETLRHEPAVKHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHED 331 Query: 420 PERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQ- 478 + ++ R + H+ FG G+ CLG LA E+ L L + L Sbjct: 332 ADTFDATRTVKE--------HLAFGHGVHFCLGAPLARMEVTLALESLFGRFPDLRLADP 383 Query: 479 -EDIKMVYSFI 488 E++ V S I Sbjct: 384 AEELPPVPSLI 394 >1UE8-A nrPDB Length = 367 Score = 151 bits (381), Expect = 6e-37, Method: Composition-based stats. Identities = 54/317 (17%), Positives = 108/317 (34%), Gaps = 46/317 (14%) Query: 167 DFSQALKKKVLQNARGS-LTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLH 225 L+ S L +D + L+ E ++ + + Sbjct: 74 PLHDELRNLTADAFNPSNLPVDFVREVT-----VKLLSELDEEFDVIESFAIPLPILVIS 128 Query: 226 ALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQ--KIYQELAFSRP 283 + + + + S + ++ + D IF G ++ ++ SR Sbjct: 129 KMLGI----NPDVKKVKDWSDLVALRLGR-----ADEIFSIGRKYLELISFSKKELDSRK 179 Query: 284 QQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE 343 + + + N+ LS + + L +TT + + E Sbjct: 180 GKEIVDLTGKIANSNLSELEKEGYFILLMIAGNETTTNLIGNAI---------------E 224 Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLV 403 S +K + A++E LR P + RV + +++ I G LV Sbjct: 225 DFTLYNSWDYVREKGALK------AVEEALRFSPPVMRTIRVTKEKVKIRDQVIDEGELV 278 Query: 404 RVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLL 463 RV++ S R+ +F P+ + P R + H+ FG G+ CLG LA E + Sbjct: 279 RVWIASANRDEEVFKDPDSFIPDRTPN--------PHLSFGSGIHLCLGAPLARLEARIA 330 Query: 464 LHHVLKHLQVETLTQED 480 L K +V+ + +++ Sbjct: 331 LEEFAKKFRVKEIVKKE 347 >5HDI-A nrPDB Length = 404 Score = 147 bits (372), Expect = 7e-36, Method: Composition-based stats. Identities = 48/238 (20%), Positives = 78/238 (32%), Gaps = 25/238 (10%) Query: 259 AWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDT 318 A I + + A +A + EL + + L A ++ Sbjct: 189 AAGVALMELSGYIFEQFDRAAADPRDNLLGELATACASGELDTLTAQVMMVTLFAAGGES 248 Query: 319 TVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPV 378 T L ++ LA P++QQ +R LL A ++ETLR P Sbjct: 249 TAALLGSAVWILATRPDIQQQVR------------------ANPELLGAFIEETLRYEPP 290 Query: 379 GLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNF 438 R + L +PA + + + + R+PA F P + R Sbjct: 291 FRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDR-------AGGK 343 Query: 439 YHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPL 496 H+ FG G C+G LA E ++L +L V + + R L Sbjct: 344 GHISFGKGAHFCVGAALARLEARIVLRLLLDRTSVIEAADVGGWLPSILVRRIERLEL 401 >6F0B-A nrPDB Length = 395 Score = 147 bits (371), Expect = 1e-35, Method: Composition-based stats. Identities = 64/340 (18%), Positives = 121/340 (35%), Gaps = 46/340 (13%) Query: 159 PMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSS 218 P + L+ + + ++P+I L + + Sbjct: 81 PPFVRTDNPDHRRLRGTIAREFLPKHIELLRPAIREIVQGV---------LDGLAETAPP 131 Query: 219 ASLNFLHALEVMFKSTVQLMFMPRSLSRWTSP--KVWKEHFEAWDC---IFQYGDNCIQK 273 + A+ V + +L+ +P + K + D +F+ I Sbjct: 132 QDMLEAFAVPVASATVFRLLGIPAEDRALLTRCVKGVVSAVGSEDEGAEVFRTLGEYIGG 191 Query: 274 IYQELAFSRPQQ--YTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELA 331 + Q+ + P+ +V +L+ + L G DTT + ++L Sbjct: 192 LVQDPS-ELPEDSLIRRLVTGPYQEKQLTFHETIGVILMLIVGGYDTTASTISLSL---- 246 Query: 332 RNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGL-FLERVASSDL 390 V AL+ E + E +PLL ++E LR + V L R+A+ D+ Sbjct: 247 ----VSYALQPEKFSVVHEHPER-------IPLL---VEELLRYHTVSQLGLGRIATEDV 292 Query: 391 VLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQC 450 + + AG +V L R+ ++FP P+ + R + HV FG+G QC Sbjct: 293 EVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDR--------PSVPHVGFGYGPHQC 344 Query: 451 LGRRLAEAEMLLLLHHVLKHLQVETL--TQEDIKMVYSFI 488 +G+ LA E+ + V++ L L ED+ + Sbjct: 345 VGQALARVELQEAIPAVIRRLPGMRLACALEDLPFRHDMA 384 >5YSW-A nrPDB Length = 441 Score = 147 bits (371), Expect = 1e-35, Method: Composition-based stats. Identities = 77/423 (18%), Positives = 127/423 (30%), Gaps = 81/423 (19%) Query: 76 GPIFRYDLGGAGMV-CVMLPEDVEKLQQVDSLHPHRMSLEPWVA---------YRQHRGH 125 GP+ R L V E+ + R PW R + Sbjct: 64 GPVARATLAAGDPFWLVSGYEEARAVLSDPRFSSDRFQYHPWFKELSPEFRERLRDDKAR 123 Query: 126 KCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLT 185 ++ PE R L + + ++ +D + A+ G T Sbjct: 124 AGSFINMDPPEHTRYRKLLTGQ-FTVRRIRELGARIDEIVAGRVDAMLA-------GGTT 175 Query: 186 LDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLS 245 D+ L G R F + + + Sbjct: 176 ADLMTEFAFPAPSLMICELLGVRY--------EDRAEFQQRASALLQMNAPVA------- 220 Query: 246 RWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAE----LSP 301 E + D + + + R I++ L+ +A L+ Sbjct: 221 ---------EAVKNADALRAFMQALVT-------DKRANPAGDIISGLIHHAGADPALTD 264 Query: 302 DAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTE 361 D + + L DTT L + +F L + P LR + A Sbjct: 265 DELINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDDPSRIAD------------ 312 Query: 362 LPLLRAALKETLRLYPVG-LFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRP 420 A++E LR V + R A DL HIPAG+ V V + + R+ +P P Sbjct: 313 ------AVEELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHWPDP 366 Query: 421 ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQED 480 + + R H+ FG G+ QCLG++LA EM +L+ L L Sbjct: 367 D-LDLTR--------PRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRLAVPP 417 Query: 481 IKM 483 ++ Sbjct: 418 EEV 420 >4XE3-A nrPDB Length = 407 Score = 147 bits (371), Expect = 1e-35, Method: Composition-based stats. Identities = 51/336 (15%), Positives = 100/336 (29%), Gaps = 34/336 (10%) Query: 160 MVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASN-LALFGERLGLVGHSPSS 218 V A L++ V + +++P + + + G LV Sbjct: 92 GVLAQDPPDHTRLRRLVGKAFTARRVEEMRPRVRSLVDSLLDDMVAHGSPADLVEFLAVP 151 Query: 219 ASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQEL 278 + + L + L ++ E Y D + Q Sbjct: 152 FPVAVICELLGVPLEDRDLFRTFSDAMLSSTRLTAAEIQRVQQDFMVYMDGLVA---QRR 208 Query: 279 AFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQ 338 ++ + L+ I + L +T+V + + L Sbjct: 209 DAPTEDLLGALALATDNDDHLTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLT------ 262 Query: 339 ALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLF--LERVASSDLVLQNYH 396 + + + L+ AA++E LR P+ RVA+ D+ L Sbjct: 263 ------------ERKRYESLVADPALVPAAVEEMLRYTPLVSAGSFVRVATEDVELSTVT 310 Query: 397 IPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLA 456 + AG V S R+ +F + + R H+ FG G C+G +L Sbjct: 311 VRAGEPCVVHFASANRDEEVFDHADELDFHR--------ERNPHIAFGHGAHHCIGAQLG 362 Query: 457 EAEMLLLLHHVLKHLQVETLTQE--DIKMVYSFILR 490 E+ L +++ L + +K ++R Sbjct: 363 RLELQEALSALVRRFPTLDLAEPVAGLKWKQGMLIR 398 >6GII-A nrPDB Length = 479 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 51/354 (14%), Positives = 112/354 (31%), Gaps = 33/354 (9%) Query: 145 NPEVLSPNAVQRFLPMVDA----VARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEAS 200 P ++R+ + ++ +++ + +P + A Sbjct: 131 QPSAEVRQVLERYGYAFNRTLVNEDEPMHLERRRVLMEPFASEHLAEHEPMVRELVRRAV 190 Query: 201 NLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLM--FMPRSLSRWTSPKVWKEHFE 258 N + R LV + + M F +E Sbjct: 191 NRFIDTGRADLVDQMIWEVPFTVALHFLGVDDDDREKMRRFAIAHTVNAFGRPSPEEQLA 250 Query: 259 AWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAEL--LLNAELSPDAIKANSMELTAGSV 316 + + Q+ C + + + + + L ++ + + + + Sbjct: 251 VAETVGQFWQFCGEVLEKMRRTADGPGWMRYSIRQQKLYPDVVTDSYLHSMMQAIIVAAH 310 Query: 317 DTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLY 376 +TTVF L L + V + + + L+ AA +E LR Sbjct: 311 ETTVFATTNALKTLLEHETVWREI------------------CADPSLIPAAAEECLRYN 352 Query: 377 PVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGR 436 R + ++ ++ +P G + + + S + A F PE ++ R Sbjct: 353 GPVAGWRRRTTREVEVEGVRLPVGANILMVVASANHDSAHFDDPEFFDIGR-------SN 405 Query: 437 NFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILR 490 H+ FG+G QCLGR L EM +++ + + L L ++ +++ R Sbjct: 406 ASEHLNFGYGAHQCLGRNLGRMEMQIMIEELSRRLPHMRLAEQRFDYLHNVSFR 459 >3SN5-A nrPDB Length = 491 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 81/445 (18%), Positives = 156/445 (35%), Gaps = 60/445 (13%) Query: 68 VHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKC 127 + ++ G +F L G + + P K+ W + K Sbjct: 39 LRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFD-------WKKFHFALSAKA 91 Query: 128 GVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGS--LT 185 P +N + + +++ + + ++ V N++ + +T Sbjct: 92 FGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVT 151 Query: 186 LDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLS 245 + + EA L +FG L + H L + Q + +L Sbjct: 152 EGMYSFCYRVMFEAGYLTIFGRDL-------TRRDTQKAHILNNLDN-FKQFDKVFPALV 203 Query: 246 RWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIV----AELLLNAELSP 301 +F+ N +K+ + L Q+ SI + LN LS Sbjct: 204 AGLPIH-----------MFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLST 252 Query: 302 -DAIKANSMELTA--GSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISE----- 353 D ++ L S T+ +LF++ RNP +A +E + + Sbjct: 253 FDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLE 312 Query: 354 -----HPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVL----QNYHIPAGTLVR 404 Q +LP+L + +KE+LRL L + R A D L +Y+I ++ Sbjct: 313 GNPICLSQAELNDLPVLDSIIKESLRLSSASLNI-RTAKEDFTLHLEDGSYNIRKDDIIA 371 Query: 405 VFLYSLGRNPALFPRPERYNPQRWLDIRGSGR----------NFYHVPFGFGMRQCLGRR 454 ++ + +P ++P P + R+LD G + +Y++PFG G C GR Sbjct: 372 LYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRL 431 Query: 455 LAEAEMLLLLHHVLKHLQVETLTQE 479 A E+ L +L + ++E + + Sbjct: 432 FAIHEIKQFLILMLSYFELELIEGQ 456 >4JBT-A nrPDB Length = 410 Score = 145 bits (365), Expect = 5e-35, Method: Composition-based stats. Identities = 69/413 (16%), Positives = 134/413 (32%), Gaps = 69/413 (16%) Query: 76 GPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCG------- 128 GP+ R DL G + V +L L + W + R Sbjct: 30 GPLTRIDLLGVPALAVTGHTLARQLLTDTRLVKDINAWSLWQSGTVTRQWPLIGMIDVDR 89 Query: 129 -VFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLD 187 +F ++GPE R R++ + L+ + P ++ + L++ +D Sbjct: 90 SMFTVDGPEHRRLRIK-TTQALTRRRLDALKPTIERYVAELLDDLER----AGADGAVVD 144 Query: 188 VQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQ-LMFMPRSLSR 246 ++ + + + AL + + L+ ++ Sbjct: 145 LKSVFAY-----------------------PLPMRVISALMGVPSEDQEQLLTWYKAFFS 181 Query: 247 WTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKA 306 +P+ E D + Y +++ E ++++ L+ + + Sbjct: 182 ILTPQD--ERLRVIDEMHGYFTEMVRRKTAEPGD---DLTSALIYATDGETPLTEEEVIG 236 Query: 307 NSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLR 366 N L A +TTV +L + L +P + +R + Sbjct: 237 NLQALVAAGHETTVSLILTAVRALLSHPEQLRLVRDGEIGW------------------E 278 Query: 367 AALKETLRLY-PVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALF-PRPERYN 424 A++ETLR PV L R A+ D+ L + IP G V + ++GR+ + + ++ Sbjct: 279 TAIEETLRWDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGRDITVHGADADDFD 338 Query: 425 PQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLT 477 R H+ FG G C G LA E + L + Sbjct: 339 ITR-------ATAARHISFGHGPHICPGAALARLEAAIALPALFTRFPHLHPA 384 >4MM0-A nrPDB Length = 399 Score = 144 bits (364), Expect = 7e-35, Method: Composition-based stats. Identities = 61/363 (16%), Positives = 123/363 (33%), Gaps = 43/363 (11%) Query: 130 FLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQ 189 F+L+ P + + L+ + + L++ + ++ ++ Sbjct: 58 FVLSDPRFSVRQDLPGAPRLTEMTFESVMTT----DPPVHTRLRRLLSRDFTARRIERMR 113 Query: 190 PSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTS 249 P + E L E + SL + V+ + M W Sbjct: 114 PRL-----EEIAEGLLDEMEKKGAPADIVESLAVPFPITVICELLGVPMVDVARFRGWAD 168 Query: 250 PKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLL-----NAELSPDAI 304 V + D + + ++ L ++ + S + L+ + EL+ + Sbjct: 169 TMVSLTGYSMED--WTAARDALESYLDGLVAAKRENPGSDLLSALVATAAEDNELTDHDV 226 Query: 305 KANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPL 364 ++ S+ L + L ++ L R P+ LR++ L Sbjct: 227 RSLSLILLLAGYEPASNQLGSSVLTLLRFPDRLAELRRDP------------------GL 268 Query: 365 LRAALKETLRLYPVGL-FLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERY 423 L +A++E +R P G L RV D+ + + HIPA + V + +P F P Sbjct: 269 LPSAVEELMRYAPAGDGALFRVTLEDVTIGDTHIPANSAVLASTQAANWDPRRFDDPTGL 328 Query: 424 NPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKM 483 R + H G G+ CLG LA E+ + + +L+ L ++ + Sbjct: 329 RLDRPDN--------QHTALGHGIHFCLGAALARVELQVAIGALLRRFPRLALATDESGL 380 Query: 484 VYS 486 +S Sbjct: 381 RWS 383 >6A7J-A nrPDB Length = 411 Score = 144 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 57/360 (15%), Positives = 119/360 (33%), Gaps = 40/360 (11%) Query: 136 EWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQP---SI 192 W+ + P + + V + L+ V Q ++ ++ Sbjct: 66 AWQRGEI---PADWPLIGLVNPGRSMLTVDGPDHRRLRTLVAQALTVKRVEKLRAGIEAL 122 Query: 193 FHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKV 252 + ++E GE + L +N + L + + + ++ S + Sbjct: 123 TNASLERLAALPAGEPVDLKAEFAYPLPMNVISELMGVDAADHPRLKEL--FEKFFSTQT 180 Query: 253 WKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAE-LSPDAIKANSMEL 311 E + KI +E + TS + + + L+ + I + Sbjct: 181 PPEEVP---QMMADLGTLFTKIVEEKKANPGDDLTSALIAASEDGDHLTDEEILNTLQLI 237 Query: 312 TAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKE 371 A +TT+ ++ + LA +P ++ + E P ++E Sbjct: 238 IAAGHETTISLIVNVVEALAIHPEQRKKVLSG---------EIPW---------EGVIEE 279 Query: 372 TLRL-YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALF-PRPERYNPQRWL 429 TLR P L R A+ D+ + + +P G + V +LGR+ + P ++ R Sbjct: 280 TLRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDEEQYGPTAGDFDATRTP 339 Query: 430 DIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFIL 489 + H+ FG G C G L+ E + L + + L ++ I+ Sbjct: 340 N--------RHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVPAAELRNKPIV 391 >6M7L-A nrPDB Length = 404 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 47/294 (15%), Positives = 91/294 (30%), Gaps = 36/294 (12%) Query: 196 TIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTV--QLMFMPRSLSRWTSPKVW 253 +E A+ + L + + + FL + + V + + +P Sbjct: 126 ALEPRVQAIVDDHLDTMASTGPP--VEFLREVAGPMAARVACEFLGIPLDDRGELIRLTA 183 Query: 254 KEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTA 313 + + + + P + A++S + + + Sbjct: 184 HRGGKRRRVLNGHAYLAYMRELAARLRRDPGDGMLGMVARDHGADISDEELAGLCAVVMN 243 Query: 314 GSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETL 373 SV+ T L L +P LR+ L A++E + Sbjct: 244 SSVEQTESCLAAGTLLLLEHPEQFALLRE------------------RPELGEQAVEEIV 285 Query: 374 RLYPVGLFL-ERVASSDLVLQNYHIPAGTLVRVFLYSLGR-NPALFPRPERYNPQRWLDI 431 R V L R A+ D+ + I G V L + R +PAL + ++ R Sbjct: 286 RYLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAANRADPAL----DGFDITR---- 337 Query: 432 RGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVY 485 + HV FG G+ CLG LA E+ + ++ ++ + Sbjct: 338 ----KESRHVAFGHGIHHCLGAPLARMELRIAFTTLVSRFPSLRTAVPAEEIRF 387 >4Z5Q-A nrPDB Length = 423 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 59/364 (16%), Positives = 116/364 (31%), Gaps = 49/364 (13%) Query: 138 RFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTI 197 RF+R + + + L+ V + + I Sbjct: 89 RFSRHLATQRDEPRMTPRAVPESILTMDPPDHTRLRTLVSKAFTPRRIESKRAWIGELAA 148 Query: 198 EASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRS----LSRWTSPKVW 253 G + A L +AL + +L+ +P L W + Sbjct: 149 GLVADMKAG---------GAPAELVGSYALAIPVTVICELLGVPEDDRTRLRGWCDAALS 199 Query: 254 KEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLL-----NAELSPDAIKANS 308 +C+ + D +QK +++L R + + L+ + L+ + Sbjct: 200 TGELTDEECVQSFMD--LQKYFEDLVKERRAEPRDDLTSALIEARDAHDRLAEPELIGLC 257 Query: 309 MELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAA 368 + + G +TT + + L + + L + A + AA Sbjct: 258 ISILIGGFETTASEISSFVHVLQQRRELWTRLCADPEA------------------IPAA 299 Query: 369 LKETLRLYPVGL--FLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQ 426 ++E LR P R A D+ + + G V V ++ R+ +F + Sbjct: 300 VEELLRFVPFAANGISPRYALEDMTVGGVLVREGEPVIVDTSAVNRDGLVFDNADEVVID 359 Query: 427 RWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYS 486 R + H+ FG G CLG LA E+ L +++ + L+ D++ Sbjct: 360 RADN--------RHMVFGHGAHHCLGAHLARVELQEALKALVEGMPGLRLSG-DVEWKAD 410 Query: 487 FILR 490 I+R Sbjct: 411 MIIR 414 >6A7I-A nrPDB Length = 411 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 47/301 (15%), Positives = 99/301 (32%), Gaps = 34/301 (11%) Query: 192 IFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPK 251 + + ++E GE + L +N + L + + + ++ S + Sbjct: 122 LTNASLEKLAALPAGEPVDLKAEFAYPLPMNVISELMGVDAADHPRLKEL--FEKFFSTQ 179 Query: 252 VWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAE-LSPDAIKANSME 310 E + KI + TS + N + L+ + I Sbjct: 180 TPPEEVP---QMMADLGALFTKIVDAKRTNPGDDLTSALIAASENGDHLTDEEIVNTLQL 236 Query: 311 LTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALK 370 + A +TT+ ++ + L +P ++ + + ++ Sbjct: 237 IIAAGHETTISLIVNVVEALQTHPEQRKKVLNGEIGW------------------DGVIE 278 Query: 371 ETLRL-YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALF-PRPERYNPQRW 428 ETLR P L R A+ D+ + + +P G + + +LGR+ + P ++ R Sbjct: 279 ETLRWNTPTSHVLIRFATEDIEVGDKILPKGEGLIISFGALGRDEEQYGPTAGEFDATRT 338 Query: 429 LDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFI 488 + H+ FG G C G L+ E + L + + L + I Sbjct: 339 PN--------RHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVPASDLRNKPI 390 Query: 489 L 489 + Sbjct: 391 V 391 >5LIV-A nrPDB Length = 450 Score = 141 bits (356), Expect = 6e-34, Method: Composition-based stats. Identities = 61/350 (17%), Positives = 112/350 (32%), Gaps = 41/350 (11%) Query: 160 MVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGE-RLGLVGHSPSS 218 + A+ D +++ + E L G+ R+ L+ Sbjct: 122 GLAAMQGDEHARMRRVYNMFFLPRAVSQYEERFVRPISEQVVDRLAGKPRVDLLEDFAME 181 Query: 219 ASLNFLHALEVMFK-----STVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQK 273 + L + ++ M R L R P E A + I + Sbjct: 182 LPRRVIGELFGFPAEKLHETDERVRAMLRGLVRMHDPAAVAESQRA----YGETLGLITE 237 Query: 274 IYQELAFSRPQQYTSIVAELLLNAELSP-DAIKANSMELTAGSVDTTVFPLLMTLFELAR 332 + + + + L + +A + + L G +TT + + T+ L Sbjct: 238 VVERESRDTSDTLLGEILRTLKAEHMDTIEASRQIVLSLILGGYETTSWLVANTIHALLA 297 Query: 333 NPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVL 392 +P+ +RQ+ LL AA++E +R P + R+ D+ L Sbjct: 298 HPDTLARVRQDP------------------SLLPAAIEEGMRWCPSSFGVLRMVERDVRL 339 Query: 393 QNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLG 452 + + AGT+V + + + +P PE Y+ R + FG G C+G Sbjct: 340 DDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDRKPLPAANV-------FGGGAHFCVG 392 Query: 453 RRLAEAEMLLLLHHVLKHLQVETLTQEDIKM-----VYSFILRPSMFPLL 497 LA E + L +L E+ S P P+L Sbjct: 393 APLARMEARVGLQALLARFPGLRAVPEERPSFMYGAKDSVAHGPDKLPVL 442 >2WIY-A nrPDB Length = 394 Score = 141 bits (356), Expect = 6e-34, Method: Composition-based stats. Identities = 41/242 (16%), Positives = 84/242 (34%), Gaps = 24/242 (9%) Query: 256 HFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGS 315 + F Y + ++ ++ + + + E++ A + A Sbjct: 175 DVDRAAVAFGYLSARVAEMLEDKRVNPGDGLADSLLDAARAGEITESEAIATILVFYAVG 234 Query: 316 VDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRL 375 + + + AR P V A R + A A A + E +R+ Sbjct: 235 HMAIGYLIASGIELFARRPEVFTAFRNDESARA------------------AIINEMVRM 276 Query: 376 YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSG 435 P L R + D+ + I AG+ +R + + R+P +F P+ ++ R Sbjct: 277 DPPQLSFLRFPTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHTR------PP 330 Query: 436 RNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFP 495 ++ FG G C G+ ++ AE + + + + L +E F R P Sbjct: 331 AASRNLSFGLGPHSCAGQIISRAEATTVFAVLAERYERIELAEEPTVAHNDFARRYRKLP 390 Query: 496 LL 497 ++ Sbjct: 391 IV 392 >6F88-A nrPDB Length = 400 Score = 141 bits (355), Expect = 7e-34, Method: Composition-based stats. Identities = 61/350 (17%), Positives = 112/350 (32%), Gaps = 41/350 (11%) Query: 160 MVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGE-RLGLVGHSPSS 218 + A+ D +++ + E L G+ R+ L+ Sbjct: 72 GLAAMQGDEHARMRRVYNMFFLPRAVSQYEERFVRPISEQVVDRLAGKPRVDLLEDFAME 131 Query: 219 ASLNFLHALEVMFK-----STVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQK 273 + L + ++ M R L R P E A + I + Sbjct: 132 LPRRVIGELFGFPAEKLHETDERVRAMLRGLVRMHDPAAVAESQRA----YGETLGLITE 187 Query: 274 IYQELAFSRPQQYTSIVAELLLNAELSP-DAIKANSMELTAGSVDTTVFPLLMTLFELAR 332 + + + + L + +A + + L G +TT + + T+ L Sbjct: 188 VVERESRDTSDTLLGEILRTLKAEHMDTIEASRQIVLSLILGGYETTSWLVANTIHALLA 247 Query: 333 NPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVL 392 +P+ +RQ+ LL AA++E +R P + R+ D+ L Sbjct: 248 HPDTLARVRQDP------------------SLLPAAIEEGMRWCPSNFGVLRMVERDVRL 289 Query: 393 QNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLG 452 + + AGT+V + + + +P PE Y+ R + FG G C+G Sbjct: 290 DDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDRKPLPAANV-------FGGGAHFCVG 342 Query: 453 RRLAEAEMLLLLHHVLKHLQVETLTQEDIKM-----VYSFILRPSMFPLL 497 LA E + L +L E+ S P P+L Sbjct: 343 APLARMEARVGLQALLARFPGLRAVPEERPSFMYGAKDSVAHGPDKLPVL 392 >6DCD-A nrPDB Length = 424 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 44/241 (18%), Positives = 82/241 (34%), Gaps = 29/241 (12%) Query: 264 FQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPD--AIKANSMELTAGSVDTTVF 321 Q+ D+ ++ + +A +P+ + ++ L A +TT Sbjct: 200 LQWLDDKFSAYIEDRRRQPRNDVLTALATATYPDGSTPEVIDVVRSATFLFAAGQETTAK 259 Query: 322 PLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLF 381 L + L P++Q+ LR+ L+ ++E+LR+ Sbjct: 260 LLTAAMRVLGDRPDIQRRLRE------------------NRSLIPNFIEESLRMDSPVKS 301 Query: 382 LERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHV 441 R+A + I AGT+V V + R+P F P + R H+ Sbjct: 302 DSRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDR-------PNVREHM 354 Query: 442 PFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRA 501 F G+ C G LA E + L +L + + ++ R + P R Sbjct: 355 AFARGVHSCPGGPLARVEGRVSLERILDRMLDIAINEDRHGPADD--RRYTYEPTYILRG 412 Query: 502 I 502 + Sbjct: 413 L 413 >2X9P-A nrPDB Length = 404 Score = 137 bits (346), Expect = 7e-33, Method: Composition-based stats. Identities = 51/323 (15%), Positives = 106/323 (32%), Gaps = 41/323 (12%) Query: 169 SQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALE 228 ++ + L++QP + + + L+ + Sbjct: 105 HAETRRLLTPLFSARRVLEMQPKVEEAADTLLDAFI---------AQGPPGDLHGELTVP 155 Query: 229 VMFKSTVQLMFMPRSLSRWTSPKVWK-EHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYT 287 +++ +P + + + + + D+ + + R + Sbjct: 156 FALTVLCEVIGVPPQRRAELTTLLAGIAKLDDREGAVRAQDDLFGYVAGLVEHKRAEPGP 215 Query: 288 SIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAA 347 I+ L + EL+ D + +M L +D+ + + LA +P+ + A Sbjct: 216 DII-SRLNDGELTEDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPDQRAA-------- 266 Query: 348 AASISEHPQKATTELPLLRAALKETLRLYPVG--LFLERVASSDLVLQNYHIPAGTLVRV 405 A + ++ A++E LR G + R AS D+ I AG LV Sbjct: 267 ----------ALADPDVMARAVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLVLF 316 Query: 406 FLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLH 465 L + F PE ++ R + H+ FG G+ C+G LA E+ + Sbjct: 317 DLGLPNFDERAFTGPEEFDAARTPN--------PHLTFGHGIWHCIGAPLARLELRTMFT 368 Query: 466 HVLKHLQ--VETLTQEDIKMVYS 486 + L L E +++ Sbjct: 369 KLFTRLPELRPELPVEQLRLKEG 391 >2UUQ-A nrPDB Length = 414 Score = 137 bits (346), Expect = 9e-33, Method: Composition-based stats. Identities = 54/339 (15%), Positives = 99/339 (29%), Gaps = 41/339 (12%) Query: 167 DFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHA 226 +K V + V+P++ + +E +V + Sbjct: 102 PVHTEFRKLVSRGFTPRQVETVEPTVRKFVVERLEKLRANGGGDIVTELFKPLPSMVVAH 161 Query: 227 LEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQY 286 + + WT V + + + L R + Sbjct: 162 YLGVPEED------WTQFDGWTQAIVAANAVDGATTGALDAVGSMMAYFTGLIERRRTEP 215 Query: 287 TSIVAELLLNAELSPDAIKANSMELTA-------GSVDTTVFPLLMTLFELARNPNVQQA 339 L+ A + D A ++ + A G DT L ++ L R P+ ++ Sbjct: 216 ADDAISHLVAAGVGADGDTAGTLSILAFTFTMVTGGNDTVTGMLGGSMPLLHRRPDQRRL 275 Query: 340 LRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPA 399 L + + A++E LRL L R + D+ + + IPA Sbjct: 276 LLDDPEG------------------IPDAVEELLRLTSPVQGLARTTTRDVTIGDTTIPA 317 Query: 400 GTLVRVFLYSLGRNPALF-PRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEA 458 G V + S R+ + P + R + F G CLG A Sbjct: 318 GRRVLLLYGSANRDERQYGPDAAELDVTRCPRNI--------LTFSHGAHHCLGAAAARM 369 Query: 459 EMLLLLHHVLKHLQVETLTQEDIKMV-YSFILRPSMFPL 496 + + L +L + + I S++ RP P Sbjct: 370 QCRVALTELLARCPDFEVAESRIVWSGGSYVRRPLSVPF 408 >3OFT-A nrPDB Length = 396 Score = 137 bits (345), Expect = 1e-32, Method: Composition-based stats. Identities = 71/353 (20%), Positives = 110/353 (31%), Gaps = 61/353 (17%) Query: 149 LSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGER 208 L+ V P V AVAR ++L+ + + D + +R Sbjct: 105 LASRFVVALEPKVQAVARKLMESLRPRGSCDF----VSDFAEILPLNIFLTLIDVPLEDR 160 Query: 209 LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGD 268 L + M TV+ + W + + Q GD Sbjct: 161 PRL-----RQLGVQLTRPDGSM---TVEQLKQAADDYLWPFIE---------KRMAQPGD 203 Query: 269 NCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLF 328 + +I E RP + D + L G +DT + M Sbjct: 204 DLFSRILSEPVGGRPW---------------TVDEARRMCRNLLFGGLDTVAAMIGMVAL 248 Query: 329 ELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASS 388 LAR+P Q+ LR+ L+ AA E +R YP + R A + Sbjct: 249 HLARHPEDQRLLRE------------------RPDLIPAAADELMRRYPTV-AVSRNAVA 289 Query: 389 DLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMR 448 D+ I G LV + +PA F PE R L H G G Sbjct: 290 DVDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDRGL------APIRHTTMGVGAH 343 Query: 449 QCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRA 501 +C+G LA E+++ L L + L + + + L +RA Sbjct: 344 RCVGAGLARMEVIVFLREWLGGMPEFALAPDKAVTMKGGNVGACTALPLVWRA 396 >1Q5D-A nrPDB Length = 419 Score = 135 bits (339), Expect = 6e-32, Method: Composition-based stats. Identities = 86/454 (18%), Positives = 146/454 (32%), Gaps = 79/454 (17%) Query: 60 GYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAY 119 GY + + +E PIF +D G + DV + + + R E Y Sbjct: 23 GYAEDPFPAIERLREATPIFYWDEG--RSWVLTRYHDVSAVFRDERFAVSREEWESSAEY 80 Query: 120 RQHRGH-----KCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKK 174 K G+F L + R +NP F + R Q Sbjct: 81 SSAIPELSDMKKYGLFGLPPEDHARVRKLVNP---------SFTSRAIDLLRAEIQRTVD 131 Query: 175 KVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKST 234 ++L G DV + Y A+ + P+ F Sbjct: 132 QLLDARSGQEEFDV---VRDYAEGIPMRAI-----SALLKVPAECDEKFRRFGSA----- 178 Query: 235 VQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELL 294 R+L P+V +E + + ++ L R + V +L Sbjct: 179 -----TARALGVGLVPRVDEE----TKTLVASVTEGLALLHGVLDERRRNPLENDVLTML 229 Query: 295 LNAE-----LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAA 349 L AE LS + A + A DTT++ + + L R+P + ++ E Sbjct: 230 LQAEADGSRLSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAEP----- 284 Query: 350 SISEHPQKATTELPLLRAALKETLRLYPVG-LFLERVASSDLVLQNYHIPAGTLVRVFLY 408 L+R AL E LR + + R A DL I G +V + + Sbjct: 285 -------------GLMRNALDEVLRFDNILRIGTVRFARQDLEYCGASIKKGEMVFLLIP 331 Query: 409 SLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVL 468 S R+ +F RP+ ++ +R + +G G C G LA E + + + Sbjct: 332 SALRDGTVFSRPDVFDVRR--------DTSASLAYGRGPHVCPGVSLARLEAEIAVGTIF 383 Query: 469 KHLQVETLTQEDIKMVY---------SFILRPSM 493 + L + + + + IL+PS Sbjct: 384 RRFPEMKLKETPVFGYHPAFRNIESLNVILKPSK 417 >6BLD-A nrPDB Length = 419 Score = 134 bits (337), Expect = 8e-32, Method: Composition-based stats. Identities = 60/345 (17%), Positives = 111/345 (32%), Gaps = 34/345 (9%) Query: 151 PNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA-LFGERL 209 P + A+ L+K V ++ SI + + G + Sbjct: 92 PAELLEASQSFLAMDPPRHTKLRKLVSAAFTPRQVRRIEDSIKINAKGIVDELRMAGGGV 151 Query: 210 GLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRS-LSRWTSPKVWKEHFEAWDCIFQYGD 268 V H + L + + ++ + + L W P+ + E +F+ Sbjct: 152 DFVEHCAKELPIRTLSDMVGIPEADRERVAHAADALVSWADPR-YLNGREPLAVLFE-NQ 209 Query: 269 NCIQKIYQELAFSRPQQYTSIVAELLLNAELSPD-----AIKANSMELTAGSVDTTVFPL 323 + ++ LA R + + L+NAE+ D + A + L DTT + Sbjct: 210 MYLHQVAASLAAERRDRPGDDLFSALVNAEVDGDRLADADVAAFFVLLAVAGNDTTRQTI 269 Query: 324 LMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 383 L L P+ + L + A++E +R + Sbjct: 270 SHGLKALTDFPSQKAWLLADFDTRIG-----------------TAVEELVRWATPVMTFR 312 Query: 384 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF 443 R A++D L I AG V +F S + F PER + R + Sbjct: 313 RTAAADFELGGQLIRAGEKVVMFYASGNWDEDAFCHPERLDLSRSPNPHVGFGGGGVH-- 370 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFI 488 CLG LA A++ + +L L + + + +F+ Sbjct: 371 -----FCLGAHLARAQLRAIFGELLVQLPDIQ-AGDPVYVPGNFV 409 >6FYJ-A nrPDB Length = 421 Score = 134 bits (337), Expect = 8e-32, Method: Composition-based stats. Identities = 78/469 (16%), Positives = 144/469 (30%), Gaps = 80/469 (17%) Query: 39 EAMPRRPGNRWLRLLQIWR--EQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPED 96 MPR G + WR E+GY + +++ IF L G +C+ E Sbjct: 7 NQMPREEG-----IDSTWRLMEEGYMYI---LNRRHSFNSDIFETRLLGKKAICMGGKEA 58 Query: 97 VEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQR 156 E + R P Q K GV L+G +R + ++SP+ +++ Sbjct: 59 AEIFYDTEKFK--RKDAAPNRVV-QTLFGKNGVQALDGQT-HKHRKEMFMSIMSPDELEK 114 Query: 157 FLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSP 216 + KK+ +D + ++ E G Sbjct: 115 -----------LTDITKKQWEIAVDKWEQMD-KVILYEEAKEIMCRTA----CQWAGVPV 158 Query: 217 SSASLNFLHA-LEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIY 275 + L L MF+S + L W Y + I+++ Sbjct: 159 QENEVKRLTKNLGAMFESAAAV-----GLKHWLGRH-----------ARNYEEIWIEELI 202 Query: 276 QELAFSRPQQYTSIVAEL------LLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFE 329 + + + L L + + + V + Sbjct: 203 DRVRDGKVNPPENTTLHKFSWYRDLEGNLLDTETAAVEVINILRPIVAI-AIFINFIALA 261 Query: 330 LARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSD 389 L P ++ L+ + + ++E R YP F+ + D Sbjct: 262 LHHYPEEKEKLKSG-----------------DKKYSQMFVQEVRRFYPFFPFVVALVKKD 304 Query: 390 LVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGM-- 447 + Y GTL + LY +P ++ P+ ++P R+ GS F +P G G Sbjct: 305 FTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDRFAKWEGS--PFSFIPQGGGDYF 362 Query: 448 --RQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMF 494 +C G + M + L ++ + E D + +S PS+ Sbjct: 363 MGHRCAGEWVTIEVMKVSLDYLTNRMDYEVP---DQDLSFSMASMPSIP 408 >5D3U-A nrPDB Length = 427 Score = 132 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 49/217 (22%), Positives = 85/217 (39%), Gaps = 15/217 (6%) Query: 272 QKIYQELAFSRPQQYTSIVAELL--LNAELSPDAIKA----NSMELTAGSVDTTVFPLLM 325 Q + QE+ + + +ELL + ++ PD + A LT + + TV L + Sbjct: 203 QPVTQEIILEKLTDLHTYASELLQGMRGKVLPDTVIARLAAAQDGLTETTPEQTVHQLAL 262 Query: 326 TLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERV 385 L P +L +LA A + + ++ + + E LR F RV Sbjct: 263 VFIALFA-PTTPGSLSSGTLAFARNPRQV-ERFLADQACVDNTANEVLRYNASNQFTWRV 320 Query: 386 ASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGF 445 A+ D+ + I AG + +FL S R+ +F RP ++ R + H+ FG Sbjct: 321 AAKDVEMGGVRIEAGQTLALFLGSANRDANMFERPNDFDLDR-------PNSARHLSFGQ 373 Query: 446 GMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIK 482 G+ CL +L ++ +L E I Sbjct: 374 GVHACLAAQLISLQLKWFYVALLNRFPGIRTAGEPIW 410 >5L1U-A nrPDB Length = 401 Score = 132 bits (332), Expect = 4e-31, Method: Composition-based stats. Identities = 51/288 (17%), Positives = 99/288 (34%), Gaps = 32/288 (11%) Query: 206 GERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWD-CIF 264 E L + S L+ + + + L+ +P + ++ + Sbjct: 124 DELLDQLAASAPPVDLHRVLSFRLPTMVVCDLLGVPLADRERFGQWARGTFDQSDNEHSA 183 Query: 265 QYGDNCIQKIYQELAFSRPQQYTSIVAELLL--NAELSPDAIKANSMELTAGSVDTTVFP 322 + + + +A R + I++EL+ + LS I + +TT+ Sbjct: 184 NTFQQVVDYMLELVARKRVEPGDDILSELIAEKDGALSDADIAHLGNAVLLFGYETTIVR 243 Query: 323 LLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRL----YPV 378 + + L RNP + L ++ L AA++E LRL Sbjct: 244 IDLGTLLLLRNPVQRAQLAEDP------------------GLAPAAVEEILRLGVGGKGS 285 Query: 379 GLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNF 438 + R A D+ + I G V + + + + FP ++ R R Sbjct: 286 NALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPDGGLFDLTR-------VRPR 338 Query: 439 YHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYS 486 H+ FG G R C+GR LA E+ + + + L L + + + Sbjct: 339 SHLAFGHGARHCIGRTLARIELTAVFERLFRRLPDLRLAVPEESLRWQ 386 >6G5O-A nrPDB Length = 399 Score = 131 bits (330), Expect = 5e-31, Method: Composition-based stats. Identities = 49/242 (20%), Positives = 88/242 (36%), Gaps = 36/242 (14%) Query: 237 LMFMPRSLSRWTS--PKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELL 294 L W S V++ EA D N + E + + +L Sbjct: 139 LNTPFSESETWISWGTHVFRSEGEALD---GDKANILYHYIDEQIDRASENPGDDMYSVL 195 Query: 295 LNAE-----LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAA 349 LN+E L+ + +K + AG DT + + ++ LA +P + LR+E Sbjct: 196 LNSEFEGRKLTKEEVKGVMVLTFAGGRDTVINAVTNSIAYLAEHPEALERLRKEPE---- 251 Query: 350 SISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYS 409 + A++E +R + + RV + D + + + A + + + S Sbjct: 252 --------------ITGRAVEEMIRYFSPLTQMGRVVTEDTHVCEHAVKADSRISLCWAS 297 Query: 410 LGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLK 469 R+ A+F P R + HV FGF CLG A + +LL + + Sbjct: 298 ANRDAAVFENPNEIVLDR--------KVNPHVGFGFSHHNCLGATHARQILKILLQTLAQ 349 Query: 470 HL 471 + Sbjct: 350 KV 351 >2NZA-A nrPDB Length = 413 Score = 129 bits (324), Expect = 3e-30, Method: Composition-based stats. Identities = 66/371 (17%), Positives = 121/371 (32%), Gaps = 50/371 (13%) Query: 138 RFNRLRLNPE---VLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFH 194 RF R + L+P+ R + A + L++ V G+ T+ + Sbjct: 71 RFGRAEVTQRQITRLAPHFKPRPGSLAFA-DQPDHNRLRRAVA----GAFTVGATKRLRP 125 Query: 195 YTIEASN-----LALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTS 249 E + + G LV + + + + + + + S +R Sbjct: 126 RAQEILDGLVDGILAEGPPADLVERVLEPFPIAVVSEVMGVPAADRERV---HSWTRQII 182 Query: 250 PKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSM 309 EA + + I + + A S S++ + E+ + Sbjct: 183 STSGGA--EAAERAKRGLYGWITETVRARAGSEGGDVYSMLGAAVGRGEVGETEAVGLAG 240 Query: 310 ELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAAL 369 L G + + L+ L + +R+ A AL Sbjct: 241 PLQIGG-EAVTHNVGQMLYLLLTRRELMARMRERPGARG------------------TAL 281 Query: 370 KETLRLYP--VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQR 427 E LR + L R+A D+ + I AG V V + R+P +FP P+R + R Sbjct: 282 DELLRWISHRTSVGLARIALEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDLDR 341 Query: 428 WLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVY-- 485 + H+ +G G C G LA + LL+ +L+ L L ++ + Sbjct: 342 DPN--------PHLAYGNGHHFCTGAVLARMQTELLVDTLLERLPGLRLAVPAEQVAWRR 393 Query: 486 -SFILRPSMFP 495 + I P P Sbjct: 394 KTMIRGPRTLP 404 >1GWI-A nrPDB Length = 411 Score = 129 bits (323), Expect = 4e-30, Method: Composition-based stats. Identities = 52/294 (17%), Positives = 98/294 (33%), Gaps = 40/294 (13%) Query: 209 LGLVGHSPSSA---SLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDC--- 262 L+ P+ L A + LM + +R KV E F + Sbjct: 128 DRLLDELPADGGVVDLKAAFAYPLPMYVVADLMGI--EEARLPRLKVLFEKFFSTQTPPE 185 Query: 263 -IFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAE----LSPDAIKANSMELTAGSVD 317 + + +A R + + L+ +E L+ I + + A + Sbjct: 186 EVVATLTELASIMTDTVAAKRAAPGDDLTSALIQASENGDHLTDAEIVSTLQLMVAAGHE 245 Query: 318 TTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYP 377 TT+ ++ + L+ +P + + + A ++ETLR Sbjct: 246 TTISLIVNAVVNLSTHPEQRALVLSGEAEWS------------------AVVEETLRFST 287 Query: 378 V-GLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALF-PRPERYNPQRWLDIRGSG 435 L R A+ D+ + + IPAG + V +LGR+ P +R++ R Sbjct: 288 PTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTADRFDLTRTSG----- 342 Query: 436 RNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFIL 489 H+ FG G C G L+ E + L + L ++ ++ Sbjct: 343 --NRHISFGHGPHVCPGAALSRMEAGVALPALYARFPHLDLAVPAAELRNKPVV 394 >5HIW-A nrPDB Length = 398 Score = 128 bits (322), Expect = 5e-30, Method: Composition-based stats. Identities = 76/422 (18%), Positives = 133/422 (31%), Gaps = 76/422 (18%) Query: 85 GAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRL 144 G G+ V+ DV + + R + G + G E RL Sbjct: 36 GLGVPVVLRGADVVAVLRDSETFSTRTYDTGIMK---------GALVTLGGEAHTRMRRL 86 Query: 145 NPEVLSPNAVQRFLP-MVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLA 203 VLSP + R+ V VAR + L +K Sbjct: 87 FNAVLSPRVISRYEEATVTPVARRVVERLVRK---------------------------- 118 Query: 204 LFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLM--FMPRSLSRWTSPKVWKEHFEAWD 261 ER L S + AL + + + + + + P+ E Sbjct: 119 ---ERAELFDDFAISMPMGVTSALFGLPEERIAENDALIRKMIRSVVMPQDPVVVAEGRS 175 Query: 262 CIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVF 321 + +E+A I ++ +A + + L GS +TT + Sbjct: 176 AHAAMEAQLREIAEREVAHPSDTLLGEIARAIVAEGLGGVEACEGVVLTLILGSYETTSW 235 Query: 322 PLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLF 381 L L L +P+ LRQ + LL A++E+ R Sbjct: 236 MLANLLVALLAHPDAMNQLRQ------------------QPSLLPQAIEESTRWCSSAAG 277 Query: 382 LERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHV 441 + R + + + AGT++ + L + + ++PRPE ++ R R + Sbjct: 278 IVRFVEREATIGGETLAAGTILYLSLIARHYDEEIYPRPETFDIHR--------RPVGML 329 Query: 442 PFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILR------PSMFP 495 FG G+ C+G LA E + + +L+ ++ +S R P P Sbjct: 330 NFGGGLHYCVGAPLARMEARVGVSLLLERFPALRADPT-VQPTFSTAPRGAAAFGPDQIP 388 Query: 496 LL 497 L Sbjct: 389 AL 390 >2IJ7-A nrPDB Length = 396 Score = 128 bits (321), Expect = 6e-30, Method: Composition-based stats. Identities = 65/366 (17%), Positives = 118/366 (32%), Gaps = 53/366 (14%) Query: 143 RLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNL 202 RLN + P V + DA L+K V++ + + + +N Sbjct: 72 RLNALTVPPEVVNNMGNIADA-------GLRKAVMKAITPKAPG-----LEQFLRDTANS 119 Query: 203 ALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDC 262 L + + A L A + +++ +P+ + + D Sbjct: 120 LL-----DNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKLFRSLSIAFMSSADP 174 Query: 263 IFQYGDNC-IQKIYQELAFSRPQQYTSIVAEL------LLNAELSPDAIKANSMELTAGS 315 I N Y P T ++ EL + +S + + Sbjct: 175 IPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAG 234 Query: 316 VDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRL 375 V +T L L L + P ++ L + + L+ A ++E LR+ Sbjct: 235 VISTGSFLTTALISLIQRPQLRNLLHE------------------KPELIPAGVEELLRI 276 Query: 376 -YPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGS 434 L R+A++D+ + + + G LV V L +P FP P R Sbjct: 277 NLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDR------- 329 Query: 435 GRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILR---P 491 H+ FG G C G L + + +LK + L ++V+ + P Sbjct: 330 PNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIP 389 Query: 492 SMFPLL 497 P+L Sbjct: 390 ERLPVL 395 >3OO3-A nrPDB Length = 384 Score = 127 bits (318), Expect = 2e-29, Method: Composition-based stats. Identities = 58/356 (16%), Positives = 121/356 (33%), Gaps = 52/356 (14%) Query: 149 LSPNAVQRFLPMV-DAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGE 207 + A + LP + A L++ V ++P I E + Sbjct: 66 VDDEADRALLPGILQAYDPPDHTRLRRTVAPAYSARRMERLRPRIEEIVEECLD------ 119 Query: 208 RLGLVGHSPSSASLNFLH--ALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQ 265 A ++F+ A + + + +PR S + +E E+ + Sbjct: 120 -----DFESVGAPVDFVRHAAWPIPAYIACEFLGVPRDDQAELSRMI-RESRESRLPRQR 173 Query: 266 YGDNC-IQKIYQEL-AFSRPQQYTSIVAELLLN--AELSPDAIKANSMELTAGSVDTTVF 321 I + L + R ++ ++ AE+S + + + + + Sbjct: 174 TLSGLGIVNYTKRLTSGKRRDPGDGMIGVIVREHGAEISDEELAGLAEGNLIMAAEQMAA 233 Query: 322 PLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLF 381 L + + L +P+ LR+ + L+ +A +E LR + Sbjct: 234 QLAVAVLLLVTHPDQMALLRE------------------KPELIDSATEEVLRHASIVEA 275 Query: 382 -LERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYH 440 RVA +D+ + I AG ++ + + R P +R++ R H Sbjct: 276 PAPRVALADVRMAGRDIHAGDVLTCSMLATNRAP-----GDRFDITR--------EKATH 322 Query: 441 VPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPL 496 + FG G+ C+G LA ++ + L V+ L + + + RP+ F + Sbjct: 323 MAFGHGIHHCIGAPLARLQLRVALPAVVGRFPSLRLAVPEEDLRFKP-GRPAPFAV 377 >3BUJ-A nrPDB Length = 397 Score = 126 bits (316), Expect = 2e-29, Method: Composition-based stats. Identities = 54/334 (16%), Positives = 104/334 (31%), Gaps = 41/334 (12%) Query: 141 RLRLNPEVLSPNAVQRF-----LPMVDAV---------ARDFSQALKKKVLQNARGSLTL 186 R L E + ++RF P + A L+ V S Sbjct: 45 RAVLGDERFARTGIRRFWTDLVGPGLLAEIVGDIILFQDEPDHGRLRGVVGPAFSPSALR 104 Query: 187 DVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKST-VQLMFMPRSLS 245 ++P I + AL + +V +L + L + + + R + Sbjct: 105 RLEPVIAGTVDDLLRPALARGAMDVVDELAYPLALRAVLGLLGLPAADWGAVGRWSRDVG 164 Query: 246 RWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIK 305 R E + +++ + +++ + +S + I Sbjct: 165 RTLDRGASAEDMRRGHAAIAEFADYVERALARRRREGGEDLLALMLDAHDRGLMSRNEIV 224 Query: 306 ANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLL 365 + + +T + + L +P+ LR+ LL Sbjct: 225 STVVTFIFTGHETVASQVGNAVLSLLAHPDQLDLLRR------------------RPDLL 266 Query: 366 RAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNP 425 A++E LR P R D+ L+ + +V V + R+P + RP+ ++ Sbjct: 267 AQAVEECLRYDPSVQSNTRQLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDFDI 326 Query: 426 QRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAE 459 +R + FG GMR CLG LA + Sbjct: 327 ER--------DPVPSMSFGAGMRYCLGSYLARTQ 352 >5YHJ-A nrPDB Length = 413 Score = 124 bits (311), Expect = 1e-28, Method: Composition-based stats. Identities = 76/433 (17%), Positives = 152/433 (35%), Gaps = 66/433 (15%) Query: 69 HQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCG 128 ++FQ IF L G ++C+ E E D+ R P + + G Sbjct: 29 RKSFQS--NIFESRLLGERVICLGGEEAAEVFY--DANKFTRQDAAP-KRLLKTLFGEGG 83 Query: 129 VFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDV 188 V L+G E +R ++ +++ + R L + + ++ VL + + + Sbjct: 84 VQTLDGSE-HTHRKQMFMSLMTKENIDRLLRLTYREWNQIERMGEEIVLYDIAQEV---L 139 Query: 189 QPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWT 248 ++ ++ G+R + ++F+S L + Sbjct: 140 MKAVCEWSGVPLAKEEVGKRTE---------------EMRLLFESGTSLG------PTYL 178 Query: 249 SPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKA-N 307 + + E W I Q L + + EL P+ + A Sbjct: 179 QGRKARSSAEVW--IRQMVKEVRSN---RLLPNEHTALYEFSWHRDESGELLPEEVVAVE 233 Query: 308 SMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRA 367 + + +V +V+ L T+ L + P+V++ + + ++ Sbjct: 234 VLNILRPTVAISVYVL-FTVLALHQFPDVKEQVERGEVSKTE------------------ 274 Query: 368 ALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQR 427 ++E R YP +D Y P GTL + LY + +++ P+R++P R Sbjct: 275 FVQEVRRFYPFFPVAAARVKTDFEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSR 334 Query: 428 WLDIRGSGRNFYHVPFGFGM----RQCLGRRLAEAEMLLLLHHVLKHLQVETL-TQEDIK 482 + D + S F +P G G +C G + + +L V++ E T Sbjct: 335 FKDWKES--PFNFIPQGGGDVDFGHRCAGEHV----TIAILAQVIELFTKEYAYTVPPQD 388 Query: 483 MVYSFILRPSMFP 495 + YSF+ PS+ Sbjct: 389 LSYSFVDMPSLPK 401 >3WEC-A nrPDB Length = 419 Score = 122 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 42/205 (20%), Positives = 71/205 (34%), Gaps = 30/205 (14%) Query: 297 AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQ 356 +LS D I A + +T +TT + L +R+ + + +R Sbjct: 236 DQLSVDEIAATCLLITVAGQETTSNTIGNMLITFSRHADQFEQVR--------------- 280 Query: 357 KATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPAL 416 + A+ E LR P R+A D + +I G V V L S R Sbjct: 281 ---ANPQFIENAVAEVLRFEPPAHEAGRIALEDCEVSGANITKGDAVMVLLASGNR--EA 335 Query: 417 FPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETL 476 R + ++ R + + +G G+ CLG LA + + L + + + + Sbjct: 336 VERGDTFSVTR--------PDVSSLSYGRGIHHCLGSALANSMLQHFLRELSQRYRSIEV 387 Query: 477 TQEDIKMVYSFILR-PSMFPLLTFR 500 E I LR P + R Sbjct: 388 A-EPINYKPGMGLRGPETLSVAVSR 411 >1WIY-A nrPDB Length = 389 Score = 121 bits (304), Expect = 5e-28, Method: Composition-based stats. Identities = 49/196 (25%), Positives = 82/196 (41%), Gaps = 23/196 (11%) Query: 297 AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQ 356 + L + + ++ L +T L + L+ P+ Q+ + + AA A+ Sbjct: 204 SHLPRERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRVAESEEAALAAF----- 258 Query: 357 KATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPAL 416 +E LRLYP L R L+L +P GT + + Y R Sbjct: 259 -------------QEALRLYPPAWILTRRLERPLLLGEDRLPQGTTLVLSPYVTQR--LY 303 Query: 417 FPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETL 476 FP E + P+R+L RG+ + + PFG G R CLGR A E ++L + +++ L Sbjct: 304 FPEGEAFQPERFLAERGTP-SGRYFPFGLGQRLCLGRDFALLEGPIVLRAFFRRFRLDPL 362 Query: 477 TQEDIKMVYSFILRPS 492 +++ LRP Sbjct: 363 PFP--RVLAQVTLRPE 376 >6G71-A nrPDB Length = 405 Score = 119 bits (297), Expect = 4e-27, Method: Composition-based stats. Identities = 46/265 (17%), Positives = 100/265 (37%), Gaps = 35/265 (13%) Query: 242 RSLSRWTSPKVWK-----EHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLN 296 L RW+ + + + W Q D + + + + + S+++ LL + Sbjct: 157 ADLQRWSQTLIDGAGNYPDDPDVWAKAKQSSDEIDAALEEMIQWHSGRPGDSLLSYLLRS 216 Query: 297 AE--LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEH 354 A+ + ++I++N G ++ L ++ L + + + Sbjct: 217 ADYQMPLESIRSNIKMTIGGGLNEPRDVLGVSTLALLSSSKQLELV-------------- 262 Query: 355 PQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNP 414 + L A +E++R + R D L Y IP G + + + S R+ Sbjct: 263 ----LRDPKLWGAVFEESIRWVAPIGMVPRQTVVDTELDGYFIPRGAKLGLCILSANRDR 318 Query: 415 ALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEML-LLLHHVLKHLQV 473 +++ P+R++ +R + H+ FG G+ CLG A +++ + L + L+ Sbjct: 319 SVWSDPDRFDIER--------GSEAHLAFGKGVHVCLGAWAARSQVADVGLPALFSRLKG 370 Query: 474 ETLTQEDIKMVYSFILR-PSMFPLL 497 L ++ R P PL+ Sbjct: 371 LRLDPNQEATHGGWVFRGPLSLPLV 395 >5HH3-A nrPDB Length = 397 Score = 118 bits (296), Expect = 6e-27, Method: Composition-based stats. Identities = 49/325 (15%), Positives = 97/325 (29%), Gaps = 46/325 (14%) Query: 169 SQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFL--HA 226 L++ V QP + ++ + ++F+ Sbjct: 99 HTRLRRMVAPAFAVRRMQKFQPQVERVVQDSLDAI-----------EALGGPVDFVPRFG 147 Query: 227 LEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQY 286 V +T + +PR + + E N ++ + Sbjct: 148 WSVATTATCDFLGIPRDDQADLARSLHASRTERSGKRRTAAGNKFMTYMNKMTARTRRDP 207 Query: 287 TSIVAELLLN---AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE 343 + +++ E++ + + + D L + +A +P LR++ Sbjct: 208 GDDMFGVVVREYGDEITDAELTGVAAFVMGAGADQVARFLAAGAWLMADDPEQFALLREK 267 Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLRLYPV-GLFLERVASSDLVLQNYHIPAGTL 402 L E +R RVA+ D+ + ++ I AG Sbjct: 268 PDTV------------------PDWLDEVIRYLTTDEKTHPRVATDDVRIGDHLIKAGDT 309 Query: 403 VRVFLYSLGRNPALFPRP-ERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEML 461 V L + R FPRP +R++ R H+ FG G+ CLGR LAE Sbjct: 310 VTCSLLAANR--RNFPRPEDRFDITR--------VRPEHLAFGHGIHHCLGRSLAELVFR 359 Query: 462 LLLHHVLKHLQVETLTQEDIKMVYS 486 + + L + ++ Sbjct: 360 TAIPALAHRFPTLRLAEPHREIRLG 384 >2IAG-A nrPDB Length = 482 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 83/467 (17%), Positives = 163/467 (34%), Gaps = 67/467 (14%) Query: 73 QELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLL 132 ++ G IF +GG + ++ P + + W + H +FL+ Sbjct: 37 EKHGDIFTILVGGRYVTVLLDPHSYDAVV--------------WEPRTRLDFHAYAIFLM 82 Query: 133 N----------GPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARG 182 P R++L + + +A+ + L + G Sbjct: 83 ERIFDVQLPHYSPSDEKARMKLTLL------HRELQALTEAMYTNLHAVLLGDATEAGSG 136 Query: 183 SLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPR 242 + + + + + A L L+G + + S + + +H+ +F + QL + Sbjct: 137 WHEMGLLDFSYSFLLRAGYLTLYGIE--ALPRTHESQAQDRVHS-ADVFHTFRQLDRLLP 193 Query: 243 SLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPD 302 L+R + K+H + + R + S + L +S + Sbjct: 194 KLARGSLSVGDKDHMCSVKSRLW---KLLSPARLARRAHRSKWLESYLLH-LEEMGVSEE 249 Query: 303 AIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEH-------P 355 + + L L +NP A+R E + + P Sbjct: 250 MQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLP 309 Query: 356 QKATTELPLLRAALKETLRLYPVGLFLERVASSDLVL-----QNYHIPAGTLVRVFL-YS 409 QK P+L + L E+LRL F+ R DL + + +++ G + +F S Sbjct: 310 QKVLDSTPVLDSVLSESLRL-TAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLS 368 Query: 410 LGRNPALFPRPERYNPQRWLDIRGSGRNFYH----------VPFGFGMRQCLGRRLAEAE 459 R+P ++ PE + R+L+ GS + ++ +P+G G CLGR A Sbjct: 369 PQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNS 428 Query: 460 MLLLLHHVLKHLQVETL-----TQEDIKMVYSF-ILRPSMFPLLTFR 500 + + VL HL +E + E Y F +++P + +R Sbjct: 429 IKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYR 475 >4FB2-A nrPDB Length = 398 Score = 112 bits (281), Expect = 2e-25, Method: Composition-based stats. Identities = 60/366 (16%), Positives = 117/366 (31%), Gaps = 38/366 (10%) Query: 114 EPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALK 173 E + + G+K ++ + N+ P + D V + + Q + Sbjct: 41 EAYGGHWVVAGYKEIQAVIQNTKAFSNKGVTFPRYETGEFELMMAGQDDPVHKKYRQLVA 100 Query: 174 KKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKS 233 K A T ++ S I+A G+ + + L + Sbjct: 101 KPFSPEATDLFTEQLRQSTNDL-IDARIELGEGDAATWLA---NEIPARLTAILLGLPPE 156 Query: 234 TVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAEL 293 + RW E+ E IF + + E + S V Sbjct: 157 DGD------TYRRWVWAITHVENPEEGAEIFAELVAHARTLIAERRTNPGNDIMSRVIMS 210 Query: 294 LLNAE-LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASIS 352 ++ E LS D + L G +D T L + LA + +++ L Sbjct: 211 KIDGESLSEDDLIGFFTILLLGGIDNTARFLSSVFWRLAWDIELRRRL------------ 258 Query: 353 EHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGR 412 L+ A+ E LR Y + + R+ + ++ + + + G ++ R Sbjct: 259 ------IAHPELIPNAVDELLRFYGPAM-VGRLVTQEVTVGDITMKPGQTAMLWFPIASR 311 Query: 413 NPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQ 472 + + F P+ +R + H+ G G+ +CLG L E + + LK + Sbjct: 312 DRSAFDSPDNIVIERTPN--------RHLSLGHGIHRCLGAHLIRVEARVAITEFLKRIP 363 Query: 473 VETLTQ 478 +L Sbjct: 364 EFSLDP 369 >3NV6-A nrPDB Length = 452 Score = 111 bits (276), Expect = 9e-25, Method: Composition-based stats. Identities = 56/355 (15%), Positives = 116/355 (32%), Gaps = 37/355 (10%) Query: 149 LSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGER 208 L A +++ + + +K + + + V+ + + Sbjct: 124 LPKEAGEKYQMVPTKMDPPEHTPYRKALDKGLNLAKIRKVEDKVREVASSLIDSFAARGE 183 Query: 209 LGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGD 268 ++ AL + + ++ + E + G+ Sbjct: 184 CDFAAEYAELFPVHVFMALADLPLEDIPVLSEYA----RQMTRPEGNTPEEMATDLEAGN 239 Query: 269 NCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIK-----ANSMELTAGSVDTTVFPL 323 N + +R + L++N+E++ + I L G +DT V L Sbjct: 240 NGFYAYVDPIIRARVGGDGDDLITLMVNSEINGERIAHDKAQGLISLLLLGGLDTVVNFL 299 Query: 324 LMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 383 + LAR+P + LR + L +E R +PV Sbjct: 300 SFFMIHLARHPELVAELRSDPLKLMRGA------------------EEMFRRFPVVSE-A 340 Query: 384 RVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPF 443 R+ + D + + G ++ + G + A P P + + R R+ H F Sbjct: 341 RMVAKDQEYKGVFLKRGDMILLPTALHGLDDAANPEPWKLDFSR--------RSISHSTF 392 Query: 444 GFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRP-SMFPLL 497 G G +C G LA E+++ L LK + + + + + +S I+ PL+ Sbjct: 393 GGGPHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEGETPIYHSGIVAAVENVPLV 447 >2ZQJ-A nrPDB Length = 417 Score = 111 bits (276), Expect = 1e-24, Method: Composition-based stats. Identities = 67/450 (14%), Positives = 136/450 (30%), Gaps = 77/450 (17%) Query: 61 YEDLHLEVHQTFQEL-GPIFRYDLGGAGMVCVMLPEDVEKLQQVD-----SLHPHRMSLE 114 ++ +L + + +F+ L G +C+ E + D + P R+ Sbjct: 18 LKEGYLFIKNRTERYNSDLFQARLLGKNFICMTGAEAAKVFYDTDRFQRQNALPKRVQKS 77 Query: 115 PWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKK 174 + G +R L +++P +R ++ + +K Sbjct: 78 LFGV--NAIQGMDG-------SAHIHRKMLFLSLMTPPHQKRLAELMTEEWKAAVTRWEK 128 Query: 175 KVLQNARGSLTLDVQPSIFHYTIEASNLAL-FGERLGLVGHSPSSASLNFLHALEVMFKS 233 + +F E + + L + +F+ ++ Sbjct: 129 AD------------EVVLFEEAKEILCRVACYWAGVPLKETEVKERADDFIDMVD----- 171 Query: 234 TVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRP----QQYTSI 289 F W + E + + + + K A Q+ S Sbjct: 172 ----AFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMAFHTQEDGSQ 227 Query: 290 VAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAA 349 + + EL N + + L+ + L +P ++ LR + Sbjct: 228 LDSRMAAIEL------INVLRPIVA----ISYFLVFSALALHEHPKYKEWLRSGNSRER- 276 Query: 350 SISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYS 409 ++E R YP G FL + D V N GT V + LY Sbjct: 277 ----------------EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYG 320 Query: 410 LGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGM----RQCLGRRLAEAEMLLLLH 465 +P L+ P+ + P+R+ + + F +P G G +C G + M L Sbjct: 321 TNHDPRLWDHPDEFRPERFAEREENL--FDMIPQGGGHAEKGHRCPGEGITIEVMKASLD 378 Query: 466 HVLKHLQVETLTQEDIKMVYSFILRPSMFP 495 ++ ++ + Q + YS PS+ Sbjct: 379 FLVHQIEYDVPEQ---SLHYSLARMPSLPE 405 >2QBO-A nrPDB Length = 421 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 57/377 (15%), Positives = 110/377 (29%), Gaps = 40/377 (10%) Query: 132 LNGPEWRFNRLRLNPEVLSPNA-VQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQP 190 NG W R +L E P + A + + + + Sbjct: 59 CNGGHWIATRGQLIREAYEDYRHFSSECPFIPREAGEAYDFIPTSMDPPEQRQFRALANQ 118 Query: 191 SIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSP 250 + ++ + L+ NF F +++ + L P Sbjct: 119 VVGMPVVDKLENRIQELACSLIESLRPQGQCNFTEDYAEPF--PIRIFMLLAGLPEEDIP 176 Query: 251 KVWKEHFEAWD----CIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAE-----LSP 301 + + F + + R Q+ + ++ N + ++ Sbjct: 177 HLKYLTDQMTRPDGSMTFAEAKEALYDYLIPIIEQRRQKPGTDAISIVANGQVNGRPITS 236 Query: 302 DAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTE 361 D K L +DT V L ++ LA++P +Q L + Sbjct: 237 DEAKRMCGLLLVVGLDTVVNFLSFSMEFLAKSPEHRQELIERPER--------------- 281 Query: 362 LPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPE 421 + AA +E LR + + R+ +SD + G + + G + P Sbjct: 282 ---IPAACEELLRRFS-LVADGRILTSDYEFHGVQLKKGDQILLPQMLSGLDERENACPM 337 Query: 422 RYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHL-QVETLTQED 480 + R + H FG G CLG+ LA E+++ L L + Sbjct: 338 HVDFSR--------QKVSHTTFGHGSHLCLGQHLARREIIVTLKEWLTRIPDFSIAPGAQ 389 Query: 481 IKMVYSFILRPSMFPLL 497 I+ + PL+ Sbjct: 390 IQHKSGIVSGVQALPLV 406 >5M0P-A nrPDB Length = 428 Score = 108 bits (270), Expect = 5e-24, Method: Composition-based stats. Identities = 66/424 (15%), Positives = 137/424 (32%), Gaps = 76/424 (17%) Query: 83 LGGAGMVCVMLPEDVEKLQ-----QVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEW 137 LGG V V E E Q + + P R+ K + ++G + Sbjct: 47 LGGKPFVVVTGKEGAEMFYNNDVVQREGMLPKRIV--------NTLAGKGAIHTVDGKK- 97 Query: 138 RFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTI 197 +R L F+ ++ ++ + L + + ++ + Y Sbjct: 98 HVDRKAL------------FMSLMTEGNLNYVRELTRTLWHANTQR--MESMDEVNIYRE 143 Query: 198 EASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHF 257 L G R V P +++M S L + + + K + Sbjct: 144 SIVLLTKVGTRWAGVQAPPEDIE-RIATDMDIMIDSFRALGG---AFKGYKASKEARRRV 199 Query: 258 EAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAEL--SPDAIKANSMELTAGS 315 E W ++I + + + + E + +P + +++L Sbjct: 200 EDW---------LEEQIIETRKGNIHPPEGTALYEFAHWEDYLGNPMDSRTCAIDLM--- 247 Query: 316 VDTTVFPL------LMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAAL 369 +T + L + NP ++ ++ E Sbjct: 248 -NTFRPLIAINRFVSFGLHAMNENPITREKIKSEPD------------------YAYKFA 288 Query: 370 KETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWL 429 +E R YP FL A D+ Q IPAG + + +Y + +L+ P + P+R+ Sbjct: 289 QEVRRYYPFVPFLPGKAKVDIDFQGVTIPAGVGLALDVYGTTHDESLWDDPNEFRPERFE 348 Query: 430 DIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVET---LTQEDIKMVYS 486 GS F +P G G R E ++++ +K+ + + ++D+++ + Sbjct: 349 TWDGS--PFDLIPQGGGDYWTNHRCAGEWITVIIMEETMKYFAEKITYDVPEQDLEVDLN 406 Query: 487 FILR 490 I Sbjct: 407 SIPG 410 >5EX8-A nrPDB Length = 424 Score = 107 bits (267), Expect = 1e-23, Method: Composition-based stats. Identities = 44/334 (13%), Positives = 94/334 (28%), Gaps = 48/334 (14%) Query: 169 SQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFL--HA 226 L++ V+ +P + ++ + ++F+ Sbjct: 126 HTRLRRMVVPAFSHRRMQKFRPRVEQIVQDSLDTI-----------ESLGGPVDFVPHFG 174 Query: 227 LEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQY 286 + +T + +PR + + + D N ++ + Sbjct: 175 WAIATPATCDFLGIPRDDQADLARILLASRTDRSDKRRTAAGNKFMTYMKQHVAQSRRGS 234 Query: 287 TSIVAELLLNAE---LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE 343 + ++ ++ + + + + D L + + P LR++ Sbjct: 235 GDDLFGIVGRENGDAITDAELTGVAAFVMGAAADQVARLLAAGAWLMVEQPAQFALLREK 294 Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLRLYPV-GLFLERVASSDLVLQNYHIPAGTL 402 L ET+R RVA+ D+ + N + AG Sbjct: 295 PETV------------------PEWLDETMRYLTTDEKTHPRVATQDVRIGNQLVKAGDT 336 Query: 403 VRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLL 462 V L + R P + ++ R H+ FG G+ CLGR +AE + Sbjct: 337 VTCSLLAANR-PNYPSAEDEFDITR--------EKAEHLAFGHGIHHCLGRAMAELMFKV 387 Query: 463 LLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPL 496 + + L L P F + Sbjct: 388 SIPALAHRFPTLRLA----DPQREITLGPPPFDV 417 >5KYO-A nrPDB Length = 430 Score = 105 bits (261), Expect = 5e-23, Method: Composition-based stats. Identities = 55/302 (18%), Positives = 104/302 (34%), Gaps = 39/302 (12%) Query: 210 GLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDN 269 L+ NF H E + V++ L PK+ + + Sbjct: 159 SLIEGFRPKGRCNFTH--EFAEQLPVRIFMRIVDLPVEDLPKLKHLADQYTRPDGSIPLD 216 Query: 270 CIQKIYQE----LAFSRPQQYTSIVAELLLNAE-----LSPDAIKANSMELTAGSVDTTV 320 + K ++E + +R + + ++N E L+ + +++ G +DT V Sbjct: 217 DVTKQFREYLRPVIEARRIKPGEDMISRMINGEVGGRPLTDIEAENICIQVLVGGLDTVV 276 Query: 321 FPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGL 380 L T LA++ +++A+ + L+ AL E R +PV Sbjct: 277 NMLGFTFSHLAKDHALRRAI------------------AADPSLIDDALLEFFRRFPVVS 318 Query: 381 FLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYH 440 R D + + AG +V + + A P + R + H Sbjct: 319 S-AREVLRDQEFEGVLLKAGDMVMAPTVVVAMDDARNEDPLEFRLGR--------KARQH 369 Query: 441 VPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFR 500 FG G C G LA EM ++L + + ++D + YS + S+ P + Sbjct: 370 STFGKGSHTCPGAHLARMEMKVVLREWFARIPEFRI-EDDAPLRYSNGIVGSVKPFVLEW 428 Query: 501 AI 502 + Sbjct: 429 PV 430 >5OMS-A nrPDB Length = 409 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 48/307 (15%), Positives = 89/307 (28%), Gaps = 45/307 (14%) Query: 169 SQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALE 228 L + + + D + E ++ G+ LGL F Sbjct: 110 IDDLVRPIARRYLERFENDGHAELVAQYCEPVSVRSLGDLLGLQEVDSDKLREWFAKLNR 169 Query: 229 VMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTS 288 + V + +P+ + E +A I D I K + S Sbjct: 170 SFTNAAVD------ENGEFANPEGFAEGDQAKAEIRAVVDPLIDKWIE-------HPDDS 216 Query: 289 IVAELLLNA-----ELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQE 343 ++ L + + I G++ + TL L P + + Sbjct: 217 AISHWLHDGMPPGQTRDREYIYPTIYVYLLGAMQEPGHGMASTLVGLFSRPEQLEEV--- 273 Query: 344 SLAAAASISEHPQKATTELPLLRAALKETLRLYPVGL-FLERVASSDLVLQNYHIPAGTL 402 + L+ A+ E LR R+++ + + +PAGT Sbjct: 274 ---------------VDDPTLIPRAIAEGLRWTSPIWSATARISTKPVTIAGVDLPAGTP 318 Query: 403 VRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLL 462 V + S + + P +Y+ R H+ FG G C G A M + Sbjct: 319 VMLSYGSANHDTGKYEAPSQYDLHR--------PPLPHLAFGAGNHACAGIYFANHVMRI 370 Query: 463 LLHHVLK 469 L + + Sbjct: 371 ALEELFE 377 >2RCM-A nrPDB Length = 495 Score = 97.1 bits (240), Expect = 2e-20, Method: Composition-based stats. Identities = 78/481 (16%), Positives = 157/481 (32%), Gaps = 63/481 (13%) Query: 26 TRAARVPRTVLPFEAMPR--------RPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGP 77 T A R LP +P +RW + +QG E+ + + Sbjct: 15 TVATRTGSKDLPIRNIPGNYGLPIVGPIKDRW----DYFYDQGAEEFFKSRIRKYNS--T 68 Query: 78 IFRYDL-------GGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVF 130 ++R ++ +V ++ + L VD + + ++ + G + Sbjct: 69 VYRVNMPPGAFIAENPQVVALLDGKSFPVLFDVDKVEKKDLLTGTYMPSTELTGGYRILS 128 Query: 131 LLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQP 190 L+ E + +L+ L ++ R P A + +L+K++ + D Sbjct: 129 YLDPSEPKHEKLKNLLFFLLKSSRNRIFPEFQATYSELFDSLEKELSLKGKA----DFGG 184 Query: 191 SIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSP 250 S A +G + A + V +F L P Sbjct: 185 SSDGTAFNFLARAFYG---------TNPADTKLKADAPGLITKWV--LFNLHPLLSIGLP 233 Query: 251 KVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSME 310 +V +E F ++ YQ L + I+ E +S + N Sbjct: 234 RVIEEPLI---HTFSLPPALVKSDYQRLYEFFLESAGEILVEA-DKLGISREEATHN--- 286 Query: 311 LTAGSVDTTVFPLLMTLFELARN-----PNVQQALRQESLAAAASIS-EHPQKATTELPL 364 L + T + + + + V L +E + S E A ++ L Sbjct: 287 LLFATCFNTWGGMKILFPNMVKRIGRAGHQVHNRLAEEIRSVIKSNGGELTMGAIEKMEL 346 Query: 365 LRAALKETLRLYPVGLFLERVASSDLVLQNY----HIPAGTLVRVFLYSLGRNPALFPRP 420 ++ + E LR P A DLV++++ + AG ++ + R+P +F R Sbjct: 347 TKSVVYECLRFEPPVTAQYGRAKKDLVIESHDAAFKVKAGEMLYGYQPLATRDPKIFDRA 406 Query: 421 ERYNPQRWLDIRGSGRNFYHVPFGFGM---------RQCLGRRLAEAEMLLLLHHVLKHL 471 + + P+R++ G + HV + G +QC G+ L + + + Sbjct: 407 DEFVPERFVGEEGE-KLLRHVLWSNGPETETPTVGNKQCAGKDFVVLVARLFVIEIFRRY 465 Query: 472 Q 472 Sbjct: 466 D 466 >3AWQ-A nrPDB Length = 415 Score = 96.8 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 28/141 (19%), Positives = 52/141 (36%), Gaps = 9/141 (6%) Query: 359 TTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFP 418 + ++E R YP + AS D + P G V + LY + A + Sbjct: 268 VQQPDYAELFVQEVRRFYPFFPAVVARASQDFEWEGMAFPEGRQVVLDLYGSNHDAATWA 327 Query: 419 RPERYNPQRWLDIRGSGRNFYHVPFGFGM----RQCLGRRLAEAEMLLLLHHVLKHLQVE 474 P+ + P+R+ +F +P G G +C G + A M + H ++ ++ Sbjct: 328 DPQEFRPERFRAWDED--SFNFIPQGGGDHYLGHRCPGEWIVLAIMKVAAHLLVNAMRY- 384 Query: 475 TLTQEDIKMVYSFILRPSMFP 495 D + F P++ Sbjct: 385 --DVPDQDLSIDFARLPALPK 403 >4C9K-A nrPDB Length = 421 Score = 96.0 bits (237), Expect = 4e-20, Method: Composition-based stats. Identities = 49/292 (16%), Positives = 90/292 (30%), Gaps = 42/292 (14%) Query: 203 ALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDC 262 FG V + AL + + + + S +E + Sbjct: 150 CEFGSEFSTV------FPVRVFLALAGLPVEDATKLGLLANEMTRPSGNTPEEQGRS--- 200 Query: 263 IFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELS-----PDAIKANSMELTAGSVD 317 + + + + +R + + +LN E+ D L G +D Sbjct: 201 -LEAANKGFFEYVAPIIAARRGGSGTDLITRILNVEIDGKPMPDDRALGLVSLLLLGGLD 259 Query: 318 TTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYP 377 T V L + L+R+P +R+E L ++E R + Sbjct: 260 TVVNFLGFMMIYLSRHPETVAEMRREPLKLQRG------------------VEELFRRFA 301 Query: 378 VGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRN 437 V R SD+ + G L+ + G + P + R R+ Sbjct: 302 VVSD-ARYVVSDMEFHGTMLKEGDLILLPTALHGLDDRHHDDPMTVDLSR--------RD 352 Query: 438 FYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFIL 489 H F G +C G LA E+ ++L L + L + + +S I+ Sbjct: 353 VTHSTFAQGPHRCAGMHLARLEVTVMLQEWLARIPEFRLKDRAVPIYHSGIV 404 >3B98-A nrPDB Length = 475 Score = 86.4 bits (212), Expect = 3e-17, Method: Composition-based stats. Identities = 52/299 (17%), Positives = 105/299 (35%), Gaps = 32/299 (10%) Query: 225 HALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQ 284 AL +++ + + L+R V KE + + + + R Q Sbjct: 179 AALTQIYEEFRRFDKLLPKLAR---TTVNKEEKQIASAAREKLWKWLTPSGLDRKP-REQ 234 Query: 285 QYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQES 344 + + L + + + + + + + L +P +A+R+E Sbjct: 235 SWLGSYVKQLQDEGIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHPEALRAVREEI 294 Query: 345 LAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVL-----QNYHIPA 399 ++ P+ + L ETLRL + R + D + Q YH+ Sbjct: 295 ---QGGKHLRLEERQKNTPVFDSVLWETLRL-TAAALITRDVTQDKKICLSNGQEYHLRR 350 Query: 400 GTLVRVFLY-SLGRNPALFPRPERYNPQRWLD----------IRGSGRNFYHVPFGFGMR 448 G + VF + S +P + +PE + R+L+ G+ + VP+G Sbjct: 351 GDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKKDFFKNGARVKYPSVPWGTEDN 410 Query: 449 QCLGRRLAEAEMLLLLHHVLKHLQVETLTQ-------EDIKMVYSFILRPSMFPLLTFR 500 C GR A + L+ +L VE + + + + IL+P+ + +R Sbjct: 411 LCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFG-ILQPAGDLEIRYR 468 >3DBM-A nrPDB Length = 473 Score = 84.0 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 65/446 (14%), Positives = 150/446 (33%), Gaps = 50/446 (11%) Query: 53 LQIWREQGYEDLHLEVHQTFQEL-GPIFRYDL-------GGAGMVCVMLPEDVEKLQQVD 104 L+ + G D + Q+ +FR ++ ++ ++ + L V Sbjct: 27 LEYFYGTGGRDEYFRSR--MQKYQSTVFRANMPPGPFVSSNPKVIVLLDAKSFPILFDVS 84 Query: 105 SLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAV 164 + + ++ + G + L+ E R +L+ + N+ R +P + Sbjct: 85 KVEKKDLFTGTYMPSTKLTGGYRVLSYLDPSEPRHAQLKNLLFFMLKNSSNRVIPQFETT 144 Query: 165 ARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFL 224 + + L+ ++ +N + + + + F + A F + Sbjct: 145 YTELFEGLEAELAKNGKAAFNDVGEQAAFRF----LGRAYFN---------SNPEETKLG 191 Query: 225 HALEVMFKSTVQLMFMPRSL---SRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFS 281 + + S V L + +L W + F + + N + +Q +A Sbjct: 192 TSAPTLISSWV-LFNLAPTLDLGLPWFLQEPLLHTFRLPAFLIKSTYNKLYDYFQSVATP 250 Query: 282 RPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALR 341 +Q + + E + + A G L N + Q L Sbjct: 251 VMEQAEKLG---VPKDEAVHNILFAVCFNTFGGVKILFPNTLKWIGLA-GENLHTQ--LA 304 Query: 342 QESLAAAASISE--HPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNY---- 395 +E A S + +A ++PL ++ + E+LR+ P A S+ ++++ Sbjct: 305 EEIRGAIKSYGDGNVTLEAIEQMPLTKSVVYESLRIEPPVPPQYGKAKSNFTIESHDATF 364 Query: 396 HIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGM-------- 447 + G ++ + ++P +F RPE Y P R++ + +V + G Sbjct: 365 EVKKGEMLFGYQPFATKDPKVFDRPEEYVPDRFVGDGEAL--LKYVWWSNGPETESPTVE 422 Query: 448 -RQCLGRRLAEAEMLLLLHHVLKHLQ 472 +QC G+ L + + + Sbjct: 423 NKQCAGKDFVVLITRLFVIELFRRYD 448 >2YJN-B nrPDB Length = 381 Score = 66.3 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 24/129 (18%), Positives = 48/129 (37%), Gaps = 18/129 (13%) Query: 312 TAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKE 371 + T ++ + ++ P + + + + AA + E Sbjct: 220 LFAGAEMTANTVVDAVLAVSAEPGLAERIADDPAAAQR------------------TVAE 261 Query: 372 TLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDI 431 LRL+P R A++++ L + I G V V + + R+P +F P+R + R Sbjct: 262 VLRLHPALHLERRTATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDRLDVDRPDAD 321 Query: 432 RGSGRNFYH 440 R + H Sbjct: 322 RALSAHRGH 330 >4YXC-B nrPDB Length = 227 Score = 33.6 bits (75), Expect = 0.23, Method: Composition-based stats. Identities = 25/91 (27%), Positives = 39/91 (42%), Gaps = 8/91 (8%) Query: 318 TTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRL-Y 376 TT +F+ +V A++ I + P K T EL R +KE LRL Sbjct: 119 TTTKSAADAVFQQLGGGDVSGAMQD-----IDLIMDIPVKLTVELGRTRMTIKELLRLTQ 173 Query: 377 PVGLFLERVASS--DLVLQNYHIPAGTLVRV 405 + L+ +A D+++ Y I G +V V Sbjct: 174 GSVVALDGLAGEPLDILINGYLIAQGEVVVV 204 >4YXB-D nrPDB Length = 80 Score = 31.3 bits (69), Expect = 0.98, Method: Composition-based stats. Identities = 16/55 (29%), Positives = 24/55 (43%), Gaps = 3/55 (5%) Query: 354 HPQKATTELPLLRAALKETLRL-YPVGLFLERVASS--DLVLQNYHIPAGTLVRV 405 EL R +KE LRL + L+ +A D+++ Y I G +V V Sbjct: 3 LDDLWADELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVV 57 >6F73-A nrPDB Length = 574 Score = 31.3 bits (69), Expect = 1.0, Method: Composition-based stats. Identities = 13/69 (18%), Positives = 25/69 (36%), Gaps = 6/69 (8%) Query: 22 QALGTRAARVPRTVLPFEAMPRRPGNRWLR----LLQIWREQGYEDLHLEVHQTFQELGP 77 + + R T+ P G+ +L L W+E Y D + + + ++ P Sbjct: 489 EEMAARDRYAAETLQPMMDAATPGGSVYLNEANHLYANWKESFYGDNYARLLRVKKKYDP 548 Query: 78 --IFRYDLG 84 +F G Sbjct: 549 DSVFYVKTG 557 >3GFZ-A nrPDB Length = 413 Score = 30.1 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 29/189 (15%), Positives = 56/189 (29%), Gaps = 25/189 (13%) Query: 263 IFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAG-------- 314 I ++G + + + P + + L+ A + + L G Sbjct: 1 ISEFGSSRMLTTLIYRSQVHPDRPPVDLDALVHRASSKNLPLGITGILLFNGLQFFQVLE 60 Query: 315 SVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLR 374 + + L + R+ +V + +R + A + L AL+E LR Sbjct: 61 GTEEALESLFSEIQSDPRHRDVVELMR-DYSAYRRFHGTGMRILDLRLFETDGALEEILR 119 Query: 375 LYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGS 434 P + L + + + PE P RW+ + S Sbjct: 120 FSTF---------------GVTEPVNDRMFRLLSAFIADGGRYCLPEPLQPSRWMMMPAS 164 Query: 435 GRNFY-HVP 442 G H+P Sbjct: 165 GTAAPQHLP 173 >3RP9-A nrPDB Length = 458 Score = 29.3 bits (64), Expect = 3.8, Method: Composition-based stats. Identities = 12/61 (19%), Positives = 18/61 (29%), Gaps = 3/61 (4%) Query: 331 ARNPNVQQALRQESLAAAASISEHPQKA---TTELPLLRAALKETLRLYPVGLFLERVAS 387 +P ++ E A P E L A +KE R +P R + Sbjct: 395 LAHPFFKEVRIAEVETNATEKVRLPFNDWMNMDEPQLRYAFVKEIQRYHPEIQLPRRSPN 454 Query: 388 S 388 Sbjct: 455 R 455 >2OG9-A nrPDB Length = 393 Score = 28.6 bits (62), Expect = 6.7, Method: Composition-based stats. Identities = 23/159 (14%), Positives = 45/159 (28%), Gaps = 1/159 (0%) Query: 108 PHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARD 167 + + A R+H G + + +W + + P + +DA + Sbjct: 189 DGALDIARVTAVRKHLGDAVPLMVDANQQWDRPTAQRMCRIFEPFNLVWIEEPLDAYDHE 248 Query: 168 FSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHAL 227 AL + L + L + VG + L Sbjct: 249 GHAALALQFDTPIATGEMLTSAAEHGDLIRHRAADYLMPDAPR-VGGITPFLKIASLAEH 307 Query: 228 EVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQY 266 + + M + L+ + W EHFE + +F Sbjct: 308 AGLMLAPHFAMELHVHLAAAYPREPWVEHFEWLEPLFNE 346 >2VUU-A nrPDB Length = 352 Score = 28.2 bits (61), Expect = 7.9, Method: Composition-based stats. Identities = 23/107 (21%), Positives = 39/107 (36%), Gaps = 12/107 (11%) Query: 103 VDSLHPHRMSLE-PWVAYRQHRGHKCGVFLLNGP-EWRFNRLRLNPEVLSPNAVQRFLPM 160 + P + PW+ G +GP +W +R+ L E LSP Sbjct: 175 FEWHAPFDPDIPLPWLDAEHDVGPALLQIFKDGPQKWNGHRIALTFETLSPV-------- 226 Query: 161 VDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGE 207 V FS+AL ++V + + V + + + +FGE Sbjct: 227 --QVCAAFSRALNRRVTYVQVPKVEIKVNIPVGYREQLEAIEVVFGE 271 >1ASZ-A nrPDB Length = 490 Score = 28.2 bits (61), Expect = 9.4, Method: Composition-based stats. Identities = 7/43 (16%), Positives = 14/43 (32%), Gaps = 5/43 (11%) Query: 30 RVPRTVLPFEAMPRRPGNRWLRLLQIWREQ-----GYEDLHLE 67 + P + PF MP ++ + G + +H Sbjct: 380 KFPLEIRPFYTMPDPANPKYSNSYDFFMRGEEILSGAQRIHDH 422 >3V7O-A nrPDB Length = 227 Score = 28.2 bits (61), Expect = 9.8, Method: Composition-based stats. Identities = 5/63 (7%), Positives = 22/63 (34%) Query: 271 IQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFEL 330 + + + + + + + A+ +P+ + ++ + L L ++ Sbjct: 46 LMEAFAKRQGKEMDSLRFLYDGIRIQADQTPEDLDMEDNDIIEAHREQIGGLTLAVLLQI 105 Query: 331 ARN 333 A + Sbjct: 106 AEH 108 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.126 0.333 Lambda K H 0.267 0.0390 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,301,114 Number of Sequences: 36641 Number of extensions: 678246 Number of successful extensions: 3133 Number of sequences better than 10.0: 182 Number of HSP's better than 10.0 without gapping: 273 Number of HSP's successfully gapped in prelim test: 75 Number of HSP's that attempted gapping in prelim test: 2295 Number of HSP's gapped (non-prelim): 365 length of query: 503 length of database: 10,336,785 effective HSP length: 101 effective length of query: 402 effective length of database: 6,636,044 effective search space: 2667689688 effective search space used: 2667689688 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.0 bits) S2: 61 (28.2 bits)