BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P15289 (507 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1E2S-P nrPDB 987 0.0 4FDJ-A nrPDB 259 1e-69 3ED4-A nrPDB 192 4e-49 6BIA-A nrPDB 182 2e-46 1P49-A nrPDB 152 5e-37 1FSU-A nrPDB 142 3e-34 4CXU-A nrPDB 102 5e-22 2QZU-A nrPDB 99 6e-21 4UPI-A nrPDB 79 3e-15 4MHX-A nrPDB 76 3e-14 5G2V-A nrPDB 75 6e-14 5G2T-A nrPDB 69 3e-12 4UPL-A nrPDB 69 5e-12 4UG4-A nrPDB 65 8e-11 4UPH-A nrPDB 61 1e-09 6IOZ-A nrPDB 59 6e-09 4UPK-A nrPDB 52 6e-07 2W8S-A nrPDB 45 1e-04 2VQR-A nrPDB 43 3e-04 5OLB-A nrPDB 38 0.010 5MHP-A nrPDB 38 0.013 4UOP-A nrPDB 36 0.044 3LXQ-A nrPDB 35 0.11 4B56-A nrPDB 33 0.38 2W5S-A nrPDB 32 0.49 6A83-A nrPDB 31 1.6 1GXS-B nrPDB 30 1.7 5TXC-A nrPDB 30 1.7 5XCX-A nrPDB 29 3.8 >1E2S-P nrPDB Length = 489 Score = 987 bits (2551), Expect = 0.0, Method: Compositional matrix adjust. Identities = 488/489 (99%), Positives = 488/489 (99%) Query: 19 RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLT 78 RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSL TPSRAALLT Sbjct: 1 RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLATPSRAALLT 60 Query: 79 GRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPH 138 GRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPH Sbjct: 61 GRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPH 120 Query: 139 QGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLE 198 QGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLE Sbjct: 121 QGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLE 180 Query: 199 ARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAV 258 ARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAV Sbjct: 181 ARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAV 240 Query: 259 GTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFW 318 GTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFW Sbjct: 241 GTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFW 300 Query: 319 PGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPS 378 PGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPS Sbjct: 301 PGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPS 360 Query: 379 YPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGEN 438 YPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGEN Sbjct: 361 YPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGEN 420 Query: 439 YNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPA 498 YNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPA Sbjct: 421 YNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPA 480 Query: 499 CCHCPDPHA 507 CCHCPDPHA Sbjct: 481 CCHCPDPHA 489 >4FDJ-A nrPDB Length = 502 Score = 259 bits (663), Expect = 1e-69, Method: Compositional matrix adjust. Identities = 189/516 (36%), Positives = 266/516 (51%), Gaps = 62/516 (12%) Query: 19 RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLT 78 +PPNI+L+ DD+G+GDLG YG PS TPNLD++AA GL F +FY L +PSRAALLT Sbjct: 3 QPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLXSPSRAALLT 62 Query: 79 GRLPVRMGMYP------GVLVPSS-RGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPE 131 GRLP+R G Y P GG+P E + E+L GY++ + GKWHLG P+ Sbjct: 63 GRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ 122 Query: 132 GAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQ-GLVPIPLLANLSV-EA 189 F P GF + G P H GP N P P + G NL EA Sbjct: 123 --FHPLKHGFDEWFGSPNCH-FGPYDNKAR--PNIPVYRDWEMVGRYYEEFPINLKTGEA 177 Query: 190 QPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGD 249 L Y+ A D + R PFFLY+A TH P ++ + F S RG +GD Sbjct: 178 N------LTQIYLQEALDFIKRQARH-HPFFLYWAVDATHAPVYASKPFLGTSQRGRYGD 230 Query: 250 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRM-SRGGCSGLLRCGKGTTYEG 308 ++ E+D ++G ++ + DL + + T V FT+DNG + +GG +G CGK TT+EG Sbjct: 231 AVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEG 290 Query: 309 GVREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAG-APLPNVTLDGFDLSPLLLGTG 366 G+REPALA+WPGH+ G V+H+L S +DL T ALAG P + +DG +L P LL G Sbjct: 291 GMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLL-QG 349 Query: 367 KSPRQSLFFYPSYPDEVRG--VFAVRTGKYKAHFFTQGSAHSD-TTADPAC--HASSSLT 421 + + +F+Y RG + A G++KAHF+T ++ + C S +T Sbjct: 350 RLMDRPIFYY-------RGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVT 402 Query: 422 AH------EPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPS 475 H + PL++ L +DPGE + L + A+ E +AL ++ + Q A+ P+ Sbjct: 403 THNLEDHTKLPLIFHLGRDPGERFPL----SFASAEYQEALSRITSVVQQHQEALV--PA 456 Query: 476 QVARGEDPALQICCH-------PGCTPRPACCHCPD 504 Q P L +C PGC C P+ Sbjct: 457 Q------PQLNVCNWAVMNWAPPGCEKLGKCLTPPE 486 >3ED4-A nrPDB Length = 502 Score = 192 bits (487), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 158/508 (31%), Positives = 226/508 (44%), Gaps = 86/508 (16%) Query: 16 AVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAA 75 A A+ PN+V+I ADDLGYGDL YGH TPN+D+LA G++FTD+Y P L +PSRA Sbjct: 23 AEAKQPNLVIIMADDLGYGDLATYGHQIVKTPNIDRLAQEGVKFTDYYAPAPLSSPSRAG 82 Query: 76 LLTGRLPVRMGMYPGVLVPSSRG-GLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAF 134 LLTGR+P R G+ +PS + L E+T+A +L A+GY T M GK HL G + Sbjct: 83 LLTGRMPFRTGIRS--WIPSGKDVALGRNELTIANLLKAQGYDTAMMGKLHLNAGGDRTD 140 Query: 135 LPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQ---GLV-PIPLLANLSVEAQ 190 P Q +G YS N F D ++ G+V P L N Q Sbjct: 141 QPQAQD----MGFDYS-----LANTAGFVTDATLDNAKERPRYGMVYPTGWLRN----GQ 187 Query: 191 P-PWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAER-------- 241 P P + Y++ D ++ +PFFLY A H P S + + + Sbjct: 188 PTPRADKMSGEYVSSEVVNWLDNKKDSKPFFLYVAFTEVHSPLASPKKYLDMYSQYMSAY 247 Query: 242 -----------------SGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGP 284 G G + ++ LDA VG ++ I +G + T+VIFT+DNGP Sbjct: 248 QKQHPDLFYGDWADKPWRGVGEYYANISYLDAQVGKVLDKIKAMGEEDNTIVIFTSDNGP 307 Query: 285 ETMRMSR------GGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGVTHEL-ASSLDLL 337 T + G + LR K +EGG+R PA+ + H+ G+ + LD + Sbjct: 308 VTREARKVYELNLAGETDGLRGRKDNLWEGGIRVPAIIKYGKHLPQGMVSDTPVYGLDWM 367 Query: 338 PTLAALAGAPLP-NVTLDGFDLSPLLLGTGKSPRQSLFFYPSYP--DEVRGVFAVRTGKY 394 PTLA + LP + T DG L P+L + L F P D+ +A+R G + Sbjct: 368 PTLAKMMNFKLPTDRTFDGESLVPVLEQKALKREKPLIFGIDMPFQDDPTDEWAIRDGDW 427 Query: 395 KAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGG-------VAG 447 K ++P LY+L D E NL+G + G Sbjct: 428 KMIIDRN---------------------NKPKYLYNLKSDRYETLNLIGKKPDIEKQMYG 466 Query: 448 ATPEVLQALKQLQLLKAQLDA--AVTFG 473 + + L+KA+ D AVT+G Sbjct: 467 KFLKYKTDIDNDSLMKARGDKPEAVTWG 494 >6BIA-A nrPDB Length = 477 Score = 182 bits (463), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 133/404 (32%), Positives = 198/404 (49%), Gaps = 31/404 (7%) Query: 8 LLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVS 67 L+ + +A + PNI+LI ADDLGY D+G G TPN+D LA G F+D YV Sbjct: 14 LVPRGSHMASEQKPNIILIVADDLGYADVGFNGSKDIITPNIDDLAKSGTSFSDAYVAHP 73 Query: 68 LCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLG 127 C PSRAAL+TGR P ++G + S G+P + ++++L Y TG GKWH+G Sbjct: 74 FCGPSRAALMTGRYPHKIGSQFNLPTRGSNVGVPTDAKFISKLLNENNYFTGALGKWHMG 133 Query: 128 VGPEGAFLPPHQGFHRFLG-IPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPI-----PL 181 P+ P +GF + G + H+ P Q + P QGL I PL Sbjct: 134 DTPQHH--PNKRGFDEYYGFLGGGHNYFPDQ----YQPQYKKQKA--QGLKNIFEYITPL 185 Query: 182 LANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYP-QFSGQSFA- 239 N + ++ +R A + + A + PFFLY A + H P Q + A Sbjct: 186 EHNGKEVKETQYITDALSRE---AVNFVDKAVNKKHPFFLYLAYNAPHTPLQAKDEDMAM 242 Query: 240 ----ERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCS 295 + R + + +D VG L+ A+ + TL++F +DNG ++S+G + Sbjct: 243 FPNIKNKDRKTYAGMVYAVDRGVGKLVEALKKNNQYDNTLIVFMSDNGG---KLSKGANN 299 Query: 296 GLLRCGKGTTYEGGVREPALAFWPGHIAPG--VTHELASSLDLLPTLAALAGAPL-PNVT 352 L+ GKG+T EGG R P L WP H+ G +H + S+LDL PT AALAGA + N Sbjct: 300 FPLKAGKGSTQEGGFRVPMLFHWPKHVPAGKRFSHPV-SALDLYPTFAALAGAKVEENQH 358 Query: 353 LDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKA 396 LDG ++ P + ++P + Y + A+R ++KA Sbjct: 359 LDGTNMWPAFI-KNENPHKDEPIYALRHRKGYSDAAIRMNQWKA 401 >1P49-A nrPDB Length = 562 Score = 152 bits (383), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 107/325 (32%), Positives = 159/325 (48%), Gaps = 21/325 (6%) Query: 181 LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE 240 ++ N + QP L R A + + + PF L + H H FS + FA Sbjct: 223 MMRNYEIIQQPMSYDNLTQRLTVEAAQFIQ--RNTETPFLLVLSYLHVHTALFSSKDFAG 280 Query: 241 RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMS-----RGGCS 295 +S G +GD++ E+D +VG ++ + +L L +TL+ FT+D G +S GG + Sbjct: 281 KSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSN 340 Query: 296 GLLRCGKGTTYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTL 353 G+ + GK +EGG+R P + WP I G E S++D+ PT+A LAGAPLP + + Sbjct: 341 GIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRII 400 Query: 354 DGFDLSPLLLG-TGKSPRQSLFFY-PSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTAD 411 DG DL PLL G + +S + LF Y +Y + VR T +KA FFT + Sbjct: 401 DGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGC 460 Query: 412 PACHA----SSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLD 467 A H S +T H+PPLL+D+SKDP E L + P + LK +Q + Sbjct: 461 FATHVCFCFGSYVTHHDPPLLFDISKDPRERNPL---TPASEPRFYEILKVMQEAADRHT 517 Query: 468 AAVTFGPSQVARGE---DPALQICC 489 + P Q + P LQ+CC Sbjct: 518 QTLPEVPDQFSWNNFLWKPWLQLCC 542 Score = 124 bits (311), Expect = 8e-29, Method: Compositional matrix adjust. Identities = 68/143 (47%), Positives = 90/143 (62%), Gaps = 9/143 (6%) Query: 18 ARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALL 77 A PNI+L+ ADDLG GD GCYG+ + TPN+D+LA+GG++ T L TPSRAA + Sbjct: 3 ASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLATPSRAAFM 62 Query: 78 TGRLPVRMGM----YPGV-LVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVG--- 129 TGR PVR GM GV L +S GGLP +E+T A++L +GY T + GKWHLG+ Sbjct: 63 TGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHS 122 Query: 130 -PEGAFLPPHQGFHRFLGIPYSH 151 + P H GF+ F GI ++ Sbjct: 123 KTDFCHHPLHHGFNYFYGISLTN 145 >1FSU-A nrPDB Length = 492 Score = 142 bits (358), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 136/470 (28%), Positives = 200/470 (42%), Gaps = 70/470 (14%) Query: 18 ARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALL 77 +RPP++V + ADDLG+ D+G +G TP+LD LAAGG+ ++Y L TPSR+ LL Sbjct: 1 SRPPHLVFLLADDLGWNDVGFHG-SRIRTPHLDALAAGGVLLDNYYTQ-PLATPSRSQLL 58 Query: 78 TGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPP 137 TGR +R G+ ++ P +PL+E + ++L GY T M GKWHLG+ + LP Sbjct: 59 TGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKEC-LPT 117 Query: 138 HQGFHRFLGI------PYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQP 191 +GF + G YSH++ C + T C G N+ Sbjct: 118 RRGFDTYFGYLLGSEDYYSHER--CTLIDAL-NVTRCALDFRDGEEVATGYKNMYSTNI- 173 Query: 192 PWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYP------QFSGQSFAERSGRG 245 R +A + ++P FLY A H P F + R Sbjct: 174 -----FTKRAIA-----LITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRH 223 Query: 246 PFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTT 305 + + +D AVG + A+ GL T+ IF+ DNG +T+ GG + LR K + Sbjct: 224 HYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTL---AGGNNWPLRGRKWSL 280 Query: 306 YEGGVREPALAFWPGHIAPGVTH-ELASSLDLLPTLAALA-GAPLPNVTLDGFDLSPLLL 363 +EGGVR P GV + EL D LPTL LA G LDGFD+ + Sbjct: 281 WEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTIS 340 Query: 364 GTGKSPRQSLFF----------------------------YPSYPDEVRGVFAVRTGKYK 395 SPR L Y ++ V A+R G +K Sbjct: 341 EGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHA--AIRHGNWK 398 Query: 396 AHFFTQGSAHSDTTADPACHASSSLTAHEPP----LLYDLSKDPGENYNL 441 G + P+ + S + + +PP L+D+ +DP E ++L Sbjct: 399 LLTGYPGCGY--WFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDL 446 >4CXU-A nrPDB Length = 536 Score = 102 bits (253), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 147/558 (26%), Positives = 217/558 (38%), Gaps = 155/558 (27%) Query: 17 VARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAAL 76 +++ PN ++I ADDLG+ D+G +G +T PNLD LA GLR TDF+ S +P+R+ L Sbjct: 1 MSKRPNFLVIVADDLGFSDIGTFGGEIAT-PNLDALAIAGLRLTDFHT-ASAASPTRSML 58 Query: 77 LTG--RLPVRMGMYPGVLVPSSRGG------LPLEEVTVAEVLAARGYLTGMAGKWHLGV 128 LTG +G L P G L V + E+L GY T MAGKWHLG+ Sbjct: 59 LTGTDHHIAGIGTMAEALTPELEGKPGYEGHLNERVVALPELLREAGYQTLMAGKWHLGL 118 Query: 129 GPEGAFLPPHQGFHR-FLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSV 187 PE P +GF R F +P N F P P D + L P L + Sbjct: 119 KPEQT--PHARGFERSFALLP------GAANHYGFEP--PYDESTPRILKGTPAL-YVED 167 Query: 188 EAQPPWLPGLEARYMAFAHDLMADAQRQD--RPFFLYYASHHTHYPQFSGQSFAER-SGR 244 E LP AF L+ + +D RPFF Y H+P + + E+ GR Sbjct: 168 ERYLDTLPEGFYSSDAFGDKLLQYLKERDQSRPFFAYLPFSAPHWPLQAPREIVEKYRGR 227 Query: 245 GPFG-DSL--------------------------------------------MELDAAV- 258 G ++L ME+ AA+ Sbjct: 228 YDAGPEALRQERLARLKELGLVEADVEAHPVLALTREWEALEDEERAKSARAMEVYAAMV 287 Query: 259 -------GTLMTAIGDLGLLEETLVIFTADNGPETMRMS--------------RGGCSGL 297 G ++ + G L+ T V+F +DNG E + R + L Sbjct: 288 ERMDWNIGRVVDYLRRQGELDNTFVLFMSDNGAEGALLEAFPKFGPDLLDFLDRHYDNSL 347 Query: 298 LRCGKGTTY-----------------------EGGVREPALAFWPGHIAPG-VTHELASS 333 G+ +Y +GG+R PAL +P G ++H A+ Sbjct: 348 ENIGRANSYVWYGPRWAQAATAPSRLYKAFTTQGGIRVPALVRYPRLSRQGAISHAFATV 407 Query: 334 LDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPR-QSLFFYPSYPDE---------- 382 +D+ PTL LAG P G +++ PR +S + S E Sbjct: 408 MDVTPTLLDLAGVRHPGKRWRGREIA--------EPRGRSWLGWLSGETEAAHDENTVTG 459 Query: 383 --VRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYN 440 + G+ A+R G +KA + PA ++ LYDL++DPGE ++ Sbjct: 460 WGLFGMRAIRQGDWKAVYL------------PAPVGPATWQ------LYDLARDPGEIHD 501 Query: 441 LLGGVAGATPEVLQALKQ 458 L G E+++ K+ Sbjct: 502 LADSQPGKLAELIEHWKR 519 >2QZU-A nrPDB Length = 491 Score = 98.6 bits (244), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 122/485 (25%), Positives = 197/485 (40%), Gaps = 82/485 (16%) Query: 4 PRSLLLA--LAAGLAVARP---PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLR 58 P++LL L+ GL PN+V I AD +GC G TP+LD+LA+ G+ Sbjct: 6 PQALLTMPILSTGLQAQEKQPTPNLVFIMADQYRGDAIGCIGKEPVKTPHLDKLASEGIN 65 Query: 59 FTDFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVT--VAEVLAARGY 116 FT+ + +P+R L+TG P+ + ++ G+ L + ++VL +GY Sbjct: 66 FTNAISSYPVSSPARGMLMTGMYPIGSKVTGNCNSETAPYGVELSQNARCWSDVLKDQGY 125 Query: 117 LTGMAGKWHL--------------GVGPEGAFLPPHQ--GFHRFLGI-PYSHDQGPCQNL 159 G GKWHL G + PP + GF ++ Y + P Sbjct: 126 NMGYIGKWHLDAPYKPYVDTYNNRGKVAWNEWCPPERRHGFDHWIAYGTYDYHLKPMYWN 185 Query: 160 TCFP-----------------PATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLE---A 199 T P A G P L+ +++ PP G E Sbjct: 186 TTAPRDSFYYVNQWGPEYEASKAIEYINGQKDQKQPFALVVSMN----PP-HTGYELVPD 240 Query: 200 RYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVG 259 RY DL +A + RP + G F R+ + + +D VG Sbjct: 241 RYKEIYKDLDVEALCKGRPDIPAKGTE-------MGDYF--RNNIRNYYACITGVDENVG 291 Query: 260 TLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGL-LRCGKGTTYEGGVREPALAFW 318 ++ A+ L + T+V+FT+D+G C G GK YE +R P + W Sbjct: 292 RIIEALKQNNLFDNTIVVFTSDHGI---------CMGAHENAGKDIFYEESMRIPMILSW 342 Query: 319 PGHIAPGVTHELASSL-DLLPTLAALAG--APLPNVTLDGFDLSPLLLGTGKSPRQSL-- 373 P I P + L + DL PTL ++ G +P T+ FDLS +L TGK+ + + Sbjct: 343 PDQIKPRKSDPLMIAFADLYPTLLSMMGFSKEIPE-TVQTFDLSNEVL-TGKNKKDLVQP 400 Query: 374 FFYPSYPDEVRGVFAVRTGKYK-AHFFTQGSAHS----DTTADPACHASSSLTAHEPPLL 428 +++ + + G +RT +Y A T G + D T DP H +++ + + L Sbjct: 401 YYFVKFDNHATGYRGLRTDRYTYAVHATDGKIDNVILFDRTNDP--HEMNNIASQQLKLT 458 Query: 429 YDLSK 433 + ++ Sbjct: 459 HTFNR 463 >4UPI-A nrPDB Length = 576 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 109/438 (24%), Positives = 159/438 (36%), Gaps = 110/438 (25%) Query: 22 NIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGRL 81 NI+ I D L + L CYGH TPN+D+LA G+RFT+ YV ++ PSR + TGR Sbjct: 30 NILWIMCDQLRFDYLSCYGHERLNTPNIDKLAKRGVRFTNAYVQATVAGPSRMSAYTGRY 89 Query: 82 PVRMGMYPGVLVPSSRGGLPLE-----------EVTVAEVLAARGYLT-GMAGKWHLGVG 129 G S++ G+PL +V + VL + ++ + G LG+ Sbjct: 90 VRSHG--------STQNGIPLRVGEPTLGDHLRDVGMRNVLIGKTHMRPDLDGMKRLGID 141 Query: 130 P---------EGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIP 180 P EG F F R G+ H G + + G Q P Sbjct: 142 PDSEIGARVGEGGF----DAFDRDDGV---HPTGYRKKEPAYNDYLRHAGF--QAENPWE 192 Query: 181 LLANLSV----EAQPPWL------------PGLEARYMAF-AHDLMADAQRQDRPFFLYY 223 AN + E Q WL E YM A + M A++ RP+ + Sbjct: 193 FWANSAEGKGGENQSGWLLTHADKPARVPEEHSETAYMTRRAMEFMEAAEKDGRPWCAHL 252 Query: 224 ASHHTHYP--------------------------------------QFSGQSFAERSGRG 245 + H+P + ++FA R Sbjct: 253 SYIKPHWPYIVPAPYHDMFGPDDVKPAVRSDEELKAAHPLFKAMTEEVYSRNFARDEVRE 312 Query: 246 PFGDSLM----ELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCG 301 + M ++D +G L + + GL E T+++FTAD+G G Sbjct: 313 KVIPAYMGLIKQIDDQLGQLFAFMQERGLDENTMIVFTADHGDYLGDHWMG--------E 364 Query: 302 KGTTYEGGVREPALAFWPGHIAPG----VTHELASSLDLLPTLAALAGAPLPNVTLDGFD 357 K YE + P + + P A V+ L +DL PT AG P L+G Sbjct: 365 KYLFYEAAAKVPLIIYDPSDKADATRGTVSDALVEMIDLAPTFVDYAGGVPPMHILEGKS 424 Query: 358 LSPLLLGTGKS-PRQSLF 374 L PLL S RQ +F Sbjct: 425 LLPLLHDDDSSWDRQYVF 442 >4MHX-A nrPDB Length = 510 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 146/565 (25%), Positives = 205/565 (36%), Gaps = 156/565 (27%) Query: 9 LALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSL 68 L L GL ARP N +L+ ADD G+ + G Y + + TP+LD LA L F + + VS Sbjct: 11 LLLVLGLCRARPRNALLLLADDGGF-ESGAYNNSAIATPHLDALARRSLLFRNAFTSVSS 69 Query: 69 CTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGV 128 +PSRA+LLTG + GMY G+ + ++ +L+ G TG+ GK H V Sbjct: 70 SSPSRASLLTGLPQHQNGMY-GLHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGKKH--V 126 Query: 129 GPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVE 188 GPE + Y+ + G + + + I LL ++ Sbjct: 127 GPETVYP---------FDFAYTEENGSVLQV-------------GRNITRIKLLVRKFLQ 164 Query: 189 AQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTH-----YPQFSGQSFAERSG 243 Q DRPFFLY A H H PQ+ +F E+ G Sbjct: 165 TQ------------------------DDRPFFLYVAFHDPHRCGHSQPQYG--TFCEKFG 198 Query: 244 RGPFG---------------DSLM----------------------ELDAAVGTLMTAIG 266 G G D L+ +D VG ++ + Sbjct: 199 NGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELR 258 Query: 267 DLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPG- 325 D G+L +TLVIFT+DNG G+ Y G EP L P H Sbjct: 259 DAGVLNDTLVIFTSDNGIP------------FPSGRTNLYWPGTAEPLLVSSPEHPKRWG 306 Query: 326 -VTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKS--------PRQSLFFY 376 V+ S LDL PT+ P P+ + G S + TG+S P + F Sbjct: 307 QVSEAYVSLLDLTPTILDWFSIPYPSYAIFG---SKTIHLTGRSLLPALEAEPLWATVFG 363 Query: 377 PSYPDEVRGVFAVRTGKYKAHFFTQGSAH--------SDTTADPACHASSSLTAHEPPL- 427 EV + +R+ +++ HF + + D P + T P Sbjct: 364 SQSHHEVTMSYPMRSVQHR-HFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTAGQPTG 422 Query: 428 ---------------LYDLSKDPGENYNLLGGVAGATPEVLQALKQL--QLLKAQLDAAV 470 LYD S+DP E NL P Q L+ L QL K Q + Sbjct: 423 WYKDLRHYYYRARWELYDRSRDPHETQNL-----ATDPRFAQLLEMLRDQLAKWQWE--- 474 Query: 471 TFGPSQVARGEDPALQICCHPGCTP 495 T P A D L+ P C P Sbjct: 475 THDPWVCA--PDGVLEEKLSPQCQP 497 >5G2V-A nrPDB Length = 534 Score = 75.1 bits (183), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 46/137 (33%), Positives = 66/137 (48%), Gaps = 14/137 (10%) Query: 18 ARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALL 77 + PNI+ + DD + CYG TPN+D++A G+RF + Y +L PSRA +L Sbjct: 26 TKRPNIIFMMTDDHTTQAMSCYGGNLIQTPNMDRIANEGIRFDNCYAVNALSGPSRACIL 85 Query: 78 TGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPP 137 TG+ G S+ G ++ T ++L GY T M GKWHL P Sbjct: 86 TGKFSHENGFTDNA---STFNG---DQQTFPKLLQQAGYQTAMIGKWHLISEP------- 132 Query: 138 HQGFHRFLGIPYSHDQG 154 QGF + + H+QG Sbjct: 133 -QGFDHWSILSGQHEQG 148 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 55/221 (24%), Positives = 95/221 (42%), Gaps = 40/221 (18%) Query: 250 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 309 +++ +D +G L+ + +G L+ T++++T+D G G G K YE Sbjct: 318 TVLAVDENIGRLLNYLEKIGELDNTIIVYTSDQGFFL------GEHGWF--DKRFMYEEC 369 Query: 310 VREPALAFWPGHIAPGVTHE-LASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKS 368 R P + +P I G T ++ ++D PT AG +P+ + G L P+L GK+ Sbjct: 370 QRMPLIIRYPKAIKAGSTSSAISMNVDFAPTFLDFAGVEVPS-DIQGASLKPVLENEGKT 428 Query: 369 P----RQSLFFYPSYPDE--VRGVFAVRTGKYK-AHFFTQGSAHSDTTADPACHASSSLT 421 P + + + Y YP E V+ + +RT +K HF+ Sbjct: 429 PADWRKAAYYHYYEYPAEHSVKRHYGIRTQDFKLIHFYNDIDEWE--------------- 473 Query: 422 AHEPPLLYDLSKDPGENYNLLGGV--AGATPEVLQALKQLQ 460 +YD+ DP E N+ G A E++Q L++ Q Sbjct: 474 ------MYDMKADPREMNNIFGKAEYAKKQKELMQLLEETQ 508 >5G2T-A nrPDB Length = 489 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 112/468 (23%), Positives = 170/468 (36%), Gaps = 96/468 (20%) Query: 14 GLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSR 73 GL PN ++I D L +G YG T +D++A+ G+ F++ YV L PSR Sbjct: 17 GLRQQEKPNFLIIQCDHLTQRVVGAYGQTQGCTLPIDEVASRGVIFSNAYVGCPLSQPSR 76 Query: 74 AALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGA 133 AAL +G +P + + P + LP T+ + + GY GK H +G Sbjct: 77 AALWSGMMPHQTNVRSNSSEPVN-TRLPENVPTLGSLFSESGYEAVHFGKTH-DMGSLRG 134 Query: 134 FLPPHQGFHRFLG--IPYSHDQ----GPCQNLTCF---PPATP--CDGGCDQ-----GLV 177 F F P ++D G C++ + PP P C G + Sbjct: 135 FKHKEPVAKPFTDPEFPVNNDSFLDVGTCEDAVAYLSNPPKEPFICIADFQNPHNICGFI 194 Query: 178 --------------PIPLL-ANLSVEAQPPW--LPGLEARYMAFAHDLMADAQRQDRPFF 220 P+P L N VE W +P +Y+ +H M A + + Sbjct: 195 GENAGVHTDRPISGPLPELPDNFDVED---WSNIP-TPVQYICCSHRRMTQAAHWNEENY 250 Query: 221 LYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTA 280 +Y + HY + + V +++ A+ T+V+ A Sbjct: 251 RHYIAAFQHYTKM--------------------VSKQVDSVLKALYSTPAGRNTIVVIMA 290 Query: 281 DNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPG--HIAPGVTHELAS-SLDLL 337 D+G G S + + Y+ P + PG V H L +LDLL Sbjct: 291 DHG-------DGMASHRMVTKHISFYDEMTNVPFIFAGPGIKQQKKPVDHLLTQPTLDLL 343 Query: 338 PTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRGVFA----VRTGK 393 PTL LAG +P G L+P L G K + + + E V VR + Sbjct: 344 PTLCDLAGIAVP-AEKAGISLAPTLRGE-KQKKSHPYVVSEWHSEYEYVTTPGRMVRGPR 401 Query: 394 YKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNL 441 YK + +G+ LYD+ KDPGE NL Sbjct: 402 YKYTHYLEGNGEE---------------------LYDMKKDPGERKNL 428 >4UPL-A nrPDB Length = 569 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 41/113 (36%), Positives = 59/113 (52%), Gaps = 10/113 (8%) Query: 22 NIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGRL 81 NI+ I D L + L CYGH + TP++D+LAA G+RF Y+ +C SR + TGR Sbjct: 19 NILFIMFDQLRWDYLSCYGHKTLNTPHIDRLAAKGVRFDRAYIQSPICGSSRMSTYTGRY 78 Query: 82 PVRMGMYPGVLVPSSRGGLPLE--EVTVAEVLAARGYLTGMAGKWHLGVGPEG 132 G +S G+PL+ E+T+ + L A G + GK H+ EG Sbjct: 79 VHSHG--------ASWNGIPLKVGEMTMGDHLRAAGMGCWLVGKTHMRADEEG 123 Score = 37.4 bits (85), Expect = 0.016, Method: Compositional matrix adjust. Identities = 41/167 (24%), Positives = 70/167 (41%), Gaps = 25/167 (14%) Query: 208 LMADAQRQD-RPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMEL----DAAVGTLM 262 + +D++RQ+ P F + G++F+ + R + M L D +G L Sbjct: 271 VRSDSERQNAHPLFKAFMDTKV------GEAFSRQEVRDAVIPAYMGLIKQADDQMGRLF 324 Query: 263 TAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTY-EGGVREPALAFWPGH 321 + D G +++T+++ T+D+ G G G+ T + + R P + + P Sbjct: 325 KWLEDTGRMQDTMIVLTSDH---------GDFLGDHWMGEKTFFHDASTRVPLIIYDPRP 375 Query: 322 IAPG----VTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLG 364 A V L S+DL PT AG L+G L P+L G Sbjct: 376 EADATRGSVCDALVESIDLAPTFVEAAGGKPAMHILEGESLIPILHG 422 >4UG4-A nrPDB Length = 515 Score = 65.1 bits (157), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 70/247 (28%), Positives = 103/247 (41%), Gaps = 39/247 (15%) Query: 230 YPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRM 289 Y F R R + ++ LD VG L+ + +L++TL++F +D+G Sbjct: 248 YQNFDVTEENVRRSRRAYFANISYLDEKVGELIDTLTRTRMLDDTLILFCSDHG------ 301 Query: 290 SRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLP 349 G GL K +EG R P + PG IAPG+ S+LD+ PTLA LAG L Sbjct: 302 DMLGERGL--WFKMNFFEGSARVPLMIAGPG-IAPGLHLTPTSNLDVTPTLADLAGISLE 358 Query: 350 NVT--LDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSD 407 V DG L P++ G ++ + + + + A+R GK+K + Sbjct: 359 EVRPWTDGVSLVPMVNGVERT--EPVLMEYAAEASYAPLVAIREGKWKYVY--------- 407 Query: 408 TTADPACHASSSLTAHEPPLLYDLSKDPGENYNL----LGGVAGATPEVLQALKQLQLLK 463 C A +P L+DL DP E NL G V AT + ++ Sbjct: 408 ------C-------ALDPEQLFDLEADPLELTNLAENPRGPVDQATLTAFRDMRAAHWDM 454 Query: 464 AQLDAAV 470 DAAV Sbjct: 455 EAFDAAV 461 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 41/113 (36%), Positives = 55/113 (48%), Gaps = 11/113 (9%) Query: 21 PNIVLIFADDLGYGDLGCYGHPSS--TTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLT 78 PNI++I D L G L G P+ PNL LA RF + Y LC P+RA+ + Sbjct: 9 PNILIIMVDQLN-GKLFPDG-PADFLHAPNLKALAKRSARFHNNYTSSPLCAPARASFMA 66 Query: 79 GRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPE 131 G+LP R +Y + +P T A L GY T ++GK H VGP+ Sbjct: 67 GQLPSRTRVYDN--AAEYQSSIP----TYAHHLRRAGYYTALSGKMHF-VGPD 112 >4UPH-A nrPDB Length = 547 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 66/227 (29%), Positives = 101/227 (44%), Gaps = 24/227 (10%) Query: 251 LMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGV 310 + E+D +G + A+ ++G ++TL+IFT+D+ E M G +L GKG ++G Sbjct: 327 IAEVDTQLGRIWQALKNVGAWDDTLIIFTSDHA-EMM-----GDHWML--GKGGFFDGSY 378 Query: 311 REPALAFWPGHIAPG----VTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLG-T 365 P + PGH PG S+ D+ PTL G +P+ LDG L P L G Sbjct: 379 HVPLVIRDPGH--PGGAGRQVERFTSAADIFPTLCDRLGL-VPDNHLDGGTLVPFLEGGE 435 Query: 366 GKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEP 425 + R + F+ + D + G+ + HF + +A + A P Sbjct: 436 PEGWRDAAFWEFDFRD-------IAKGEAERHFGLKSNACNLAVIRDERFKYVHF-AGLP 487 Query: 426 PLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTF 472 PLLYDL+KDP E N+ A + A K L L LD + + Sbjct: 488 PLLYDLAKDPMELTNVAADADYAAVRLGYAEKLLSLRAQHLDQTLAY 534 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 33/96 (34%), Positives = 45/96 (46%), Gaps = 8/96 (8%) Query: 19 RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLT 78 + PN++LI AD L GH S TPN+D LA G+ FT + + +P+RA L T Sbjct: 43 KRPNVLLISADQWRGDCLSAVGHASVKTPNVDALAQDGVLFTRHFAGTAPASPARATLYT 102 Query: 79 GRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAAR 114 G + + R G PL+ LAAR Sbjct: 103 GLYQMNHRV--------CRNGSPLDARFDNLALAAR 130 >6IOZ-A nrPDB Length = 517 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 37/109 (33%), Positives = 53/109 (48%), Gaps = 5/109 (4%) Query: 22 NIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGRL 81 N++LI DDL LGCYG +PN+DQLA+ L F + + ++ PSR + LTGR Sbjct: 5 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVAAPSRVSFLTGRR 63 Query: 82 PVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGK-WHLGVG 129 P +Y G T+ + GY+T GK +H G+ Sbjct: 64 PDTTRLYDFNSYWRVHAG---NFSTIPQYFKENGYVTMSVGKVFHPGIS 109 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 35/135 (25%), Positives = 55/135 (40%), Gaps = 33/135 (24%) Query: 240 ERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLR 299 +R R + S+ LD VG L++A+ DL L T++ FT+D+G + G Sbjct: 260 QRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG---WALGEHG-----E 311 Query: 300 CGKGTTYEGGVREPALAFWPGHIA------------------------PG-VTHELASSL 334 K + ++ P + + PG A PG + +L + Sbjct: 312 WAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELV 371 Query: 335 DLLPTLAALAGAPLP 349 L PTLA LAG +P Sbjct: 372 SLFPTLAGLAGLQVP 386 >4UPK-A nrPDB Length = 538 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 36/123 (29%), Positives = 55/123 (44%), Gaps = 9/123 (7%) Query: 253 ELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVRE 312 E+D +G ++ + + G ++TL++ TAD+G M R GK T Y+ Sbjct: 319 EVDTHIGRVIAHLKETGQYDDTLIVVTADHG--EMLGDRHSW------GKMTVYDAAYHT 370 Query: 313 PALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQS 372 P + PG V S+DL+PT+ G +PN +DG L P L G S + Sbjct: 371 PLIIRAPGCKPGHVVEAPTESIDLMPTILDWVGQEIPNA-VDGRSLRPFLTGEAPSDWRQ 429 Query: 373 LFF 375 F Sbjct: 430 YSF 432 Score = 35.8 bits (81), Expect = 0.051, Method: Compositional matrix adjust. Identities = 30/104 (28%), Positives = 43/104 (41%), Gaps = 10/104 (9%) Query: 16 AVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAA 75 ++ R N++ I D L L P+L LA + F Y + C PSRA+ Sbjct: 29 SMGRQSNVLFIIIDQLRADCLWGALADHVELPHLRALAQDAVSFRRHYSVTNPCGPSRAS 88 Query: 76 LLTGRLPVRMGMYPGVLVPSSRGGLPLEEVT--VAEVLAARGYL 117 +LTG+ + S R G PL T +A + GYL Sbjct: 89 ILTGQYAMNHR--------SVRNGTPLRHDTPNIATEMRKAGYL 124 >2W8S-A nrPDB Length = 543 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 68/276 (24%), Positives = 100/276 (36%), Gaps = 36/276 (13%) Query: 211 DAQRQDRPFFLYYASH-----HTHYPQFSGQSFAE---RSGRGPFGDSLMELDAAVGTLM 262 DA+ P +Y H H + SG + E R R + + E+D +G + Sbjct: 275 DAEAAQHPLMKHYIDHIRRGSFFHGAEGSGATLDEGEIRQMRATYCGLITEIDDCLGRVF 334 Query: 263 TAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHI 322 + + G ++TL+IFT+D+G + G LL GK R P + G Sbjct: 335 AYLDETGQWDDTLIIFTSDHGEQL------GDHHLL--GKIGYNAESFRIPLVIKDAGQN 386 Query: 323 --APGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYP 380 A + + S+D++PT+ G P DG L P L S ++ Y Sbjct: 387 RHAGQIEEGFSESIDVMPTILEWLGGETPRAC-DGRSLLPFLAEGKPSDWRTELHYEF-- 443 Query: 381 DEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHE-----PPLLYDLSKDP 435 + R VF + Q S C + PPL +DL DP Sbjct: 444 -DFRDVFYDQ---------PQNSVQLSQDDCSLCVIEDENYKYVHFAALPPLFFDLKADP 493 Query: 436 GENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVT 471 E NL G A A A K L + D +T Sbjct: 494 HEFSNLAGDPAYAALVRDYAQKALSWRLSHADRTLT 529 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 17/38 (44%), Positives = 21/38 (55%) Query: 42 PSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTG 79 P TPNLD+L GL F + P+RA+LLTG Sbjct: 59 PFLKTPNLDRLCREGLTFRNHVTTCVPGGPARASLLTG 96 >2VQR-A nrPDB Length = 543 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 59/234 (25%), Positives = 87/234 (37%), Gaps = 20/234 (8%) Query: 241 RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRC 300 R R + + E+D +G + + + + G ++TL+IFT+D+G + G LL Sbjct: 313 RQMRATYCGLITEVDDCLGRVFSYLDETGQWDDTLIIFTSDHGEQL------GDHHLL-- 364 Query: 301 GKGTTYEGGVREPALAFWPGHIAP--GVTHELASSLDLLPTLAALAGAPLPNVTLDGFDL 358 GK + R P + G A + S+D++PT+ G +P+ DG L Sbjct: 365 GKIGYNDPSFRIPLVIKDAGENARAGAIESGFTESIDVMPTILDWLGGKIPHAC-DGLSL 423 Query: 359 SPLL-LGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHAS 417 P L G + R L Y + R V+ F G Sbjct: 424 LPFLSEGRPQDWRTEL----HYEYDFRDVYYSEPQS----FLGLGMNDCSLCVIQDERYK 475 Query: 418 SSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVT 471 A PPL +DL DP E NL A A A K L D +T Sbjct: 476 YVHFAALPPLFFDLRHDPNEFTNLADDPAYAALVRDYAQKALSWRLKHADRTLT 529 Score = 29.6 bits (65), Expect = 3.2, Method: Compositional matrix adjust. Identities = 15/34 (44%), Positives = 20/34 (58%) Query: 46 TPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTG 79 TPNLD+L G+ F + P+RA+LLTG Sbjct: 63 TPNLDRLCREGVTFRNHVTTCVPAGPARASLLTG 96 >5OLB-A nrPDB Length = 844 Score = 38.1 bits (87), Expect = 0.010, Method: Compositional matrix adjust. Identities = 24/69 (34%), Positives = 32/69 (46%), Gaps = 10/69 (14%) Query: 227 HTHYPQFSGQSFAERSGRGPFG----DSLMELDAAVGTLMTAIGDLGLLEETLVIFTADN 282 ++ P FSG + GPFG + L E+D VG LM + L L VIF D+ Sbjct: 275 YSEQPDFSGHKY------GPFGPEMTNPLREIDKTVGQLMDGLKQLKLHRCVNVIFVGDH 328 Query: 283 GPETMRMSR 291 G E + R Sbjct: 329 GMEDVTCDR 337 >5MHP-A nrPDB Length = 871 Score = 37.7 bits (86), Expect = 0.013, Method: Compositional matrix adjust. Identities = 24/69 (34%), Positives = 32/69 (46%), Gaps = 10/69 (14%) Query: 227 HTHYPQFSGQSFAERSGRGPFG----DSLMELDAAVGTLMTAIGDLGLLEETLVIFTADN 282 ++ P FSG + GPFG + L E+D VG LM + L L VIF D+ Sbjct: 307 YSEQPDFSGHKY------GPFGPEMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDH 360 Query: 283 GPETMRMSR 291 G E + R Sbjct: 361 GMEDVTCDR 369 >4UOP-A nrPDB Length = 442 Score = 35.8 bits (81), Expect = 0.044, Method: Compositional matrix adjust. Identities = 26/121 (21%), Positives = 50/121 (41%), Gaps = 12/121 (9%) Query: 245 GPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIF-------TADNGPETMRMSRGGCSGL 297 G + +++ D +G + + D G+ ++++V+F D PE + S Sbjct: 248 GNYFEAVHYADKQLGEFIQKLKDSGIWDDSVVVFYGDHHIIKTDQLPEEQK-KYVNRSTQ 306 Query: 298 LRCGKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFD 357 L+ Y R P +PG PG + +D++PT+ L G + + G D Sbjct: 307 LKAEPADDY----RIPFFLHYPGMENPGEIKNVGGEIDIMPTVMNLLGIKTGDQIMFGTD 362 Query: 358 L 358 + Sbjct: 363 I 363 >3LXQ-A nrPDB Length = 450 Score = 34.7 bits (78), Expect = 0.11, Method: Compositional matrix adjust. Identities = 75/339 (22%), Positives = 116/339 (34%), Gaps = 77/339 (22%) Query: 19 RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLT 78 + N+V++ + LG +G G TPNLD+L G +FT Y + A+ T Sbjct: 84 KRKNLVILLQESLGAQFVGSLGGLP-LTPNLDELMQEGWQFTQMYATGTRSVRGIEAVTT 142 Query: 79 GR--LPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLP 136 G P R V + S+ G T+A++L +GY T G E F Sbjct: 143 GFPPSPSR----AVVKLSKSQTGF----FTIADLLKEQGYHT------QFIYGGEANF-- 186 Query: 137 PHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPG 196 N+ F G DQ VE + PG Sbjct: 187 --------------------DNMKTF----FFGNGFDQ-----------IVEEKNYTNPG 211 Query: 197 LEARYMAFAHDLMADAQRQ-------DRPFF--LYYASHHTHYPQFSGQSFAERSGRGPF 247 + DL A + D+PFF ++ +S+H+ Y G+ S Sbjct: 212 FVGSWGVSDEDLYNKADEEFERLSKGDKPFFSLVFTSSNHSPYEYPEGKIEQYDSEHMTR 271 Query: 248 GDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYE 307 +++ D A+GT ++T+ I AD+ G Sbjct: 272 NNAVKYSDYALGTFFDKAKKSSYWDDTIFIVIADHDARVF-------------GANLVPV 318 Query: 308 GGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGA 346 PAL I P +A+++D+ PTL +L G Sbjct: 319 KHFHIPALII-GKDIQPRKDDRIANNIDMPPTLLSLIGV 356 >4B56-A nrPDB Length = 820 Score = 32.7 bits (73), Expect = 0.38, Method: Compositional matrix adjust. Identities = 21/71 (29%), Positives = 33/71 (46%), Gaps = 8/71 (11%) Query: 250 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 309 +L ++D VG LM + DLGL + +I +D+G M +G C + K Y G Sbjct: 288 ALQKVDRLVGMLMDGLKDLGLDKCLNLILISDHG-----MEQGSCKKYVYLNK---YLGD 339 Query: 310 VREPALAFWPG 320 V + + P Sbjct: 340 VNNVKVVYGPA 350 >2W5S-A nrPDB Length = 424 Score = 32.3 bits (72), Expect = 0.49, Method: Compositional matrix adjust. Identities = 37/163 (22%), Positives = 65/163 (39%), Gaps = 38/163 (23%) Query: 218 PFFLYYASHHTHYPQFSGQSFA--ERSGRGP-----FGDSLMELDAAVGTLMTAIGDLGL 270 PF+ + + HYP + A E+S G + + LD A+ + + GL Sbjct: 188 PFYSHLITLTNHYPFTLDEKDATIEKSNTGDATVDGYIQTARYLDEALEEYINDLKKKGL 247 Query: 271 LEETLVIFTAD---------NGPETM---RMSRGGCSGLLRCGKGTTYEGGVREPALAFW 318 + ++++ D N E + +++ + L R G FW Sbjct: 248 YDNSVIMIYGDHYGISENHNNAMEKLLGEKITPAKFTDLNRTG---------------FW 292 Query: 319 ---PGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDL 358 PG + G+ +E A +D++PT+ LAG N + G DL Sbjct: 293 IKIPGK-SGGINNEYAGQVDVMPTILHLAGIDTKNYLMFGTDL 334 >6A83-A nrPDB Length = 394 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 15/44 (34%), Positives = 20/44 (45%) Query: 19 RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDF 62 P +VL+ + G + YG+P TTP LD L T F Sbjct: 52 EPRTLVLVIGESTQRGRMSLYGYPRETTPELDALHKTDPNLTVF 95 >1GXS-B nrPDB Length = 158 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 22/57 (38%), Positives = 26/57 (45%), Gaps = 9/57 (15%) Query: 47 PNLDQLAAGGLRF------TDFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSR 97 P +L GLR TD VPVS S AAL LPV+ YP + P+ R Sbjct: 57 PVYRELIQAGLRVWVYSGDTDSVVPVSSTRRSLAAL---ELPVKTSWYPWYMAPTER 110 >5TXC-A nrPDB Length = 705 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 24/69 (34%), Positives = 35/69 (50%), Gaps = 2/69 (2%) Query: 287 MRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGA 346 MR S+ C G +R G T G + P +AF AP VT E+ L + T++A Sbjct: 1 MRSSKIRCPGAIRVGTLVTAFGCL--PHVAFAAAREAPPVTPEVLVRLADIGTMSASETT 58 Query: 347 PLPNVTLDG 355 PL +++ DG Sbjct: 59 PLLSLSPDG 67 >5XCX-A nrPDB Length = 172 Score = 29.3 bits (64), Expect = 3.8, Method: Compositional matrix adjust. Identities = 16/40 (40%), Positives = 20/40 (50%), Gaps = 1/40 (2%) Query: 376 YPSYPDEVRGVFAVRTGKYKAHFFTQ-GSAHSDTTADPAC 414 Y YPD V+G F + K K + Q GS S+ TA C Sbjct: 58 YTYYPDSVKGRFTISRDKAKNTLYLQMGSLKSEDTAMYYC 97 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1E2S-P nrPDB 672 0.0 1P49-A nrPDB 445 e-125 4FDJ-A nrPDB 441 e-124 3ED4-A nrPDB 391 e-109 6BIA-A nrPDB 385 e-107 1FSU-A nrPDB 373 e-103 2QZU-A nrPDB 338 4e-93 4UPI-A nrPDB 324 6e-89 4CXU-A nrPDB 319 2e-87 5G2T-A nrPDB 311 6e-85 4MHX-A nrPDB 302 3e-82 2VQR-A nrPDB 286 2e-77 4UPH-A nrPDB 283 1e-76 4UG4-A nrPDB 283 1e-76 2W8S-A nrPDB 281 7e-76 4UPL-A nrPDB 269 2e-72 4UPK-A nrPDB 215 4e-56 6IOZ-A nrPDB 203 2e-52 5G2V-A nrPDB 180 1e-45 Sequences not found previously or not previously below threshold: 3LXQ-A nrPDB 103 2e-22 4UOP-A nrPDB 99 5e-21 2W8D-A nrPDB 75 6e-14 5I5H-A nrPDB 71 8e-13 5I5F-A nrPDB 71 8e-13 2W5S-A nrPDB 70 2e-12 4UOO-A nrPDB 67 2e-11 5KGM-A nrPDB 55 7e-08 5UDY-A nrPDB 55 8e-08 4LR2-A nrPDB 51 1e-06 1O99-A nrPDB 48 7e-06 4B56-A nrPDB 45 6e-05 5VPU-A nrPDB 45 8e-05 4QAX-A nrPDB 43 2e-04 6A83-A nrPDB 43 4e-04 5XWI-A nrPDB 42 8e-04 6C01-A nrPDB 41 0.002 5VEN-A nrPDB 40 0.002 6G4G-A nrPDB 39 0.004 5VEM-A nrPDB 39 0.004 6BNF-A nrPDB 39 0.004 2IFY-A nrPDB 38 0.009 3IGZ-B nrPDB 38 0.012 5MX9-A nrPDB 38 0.014 5MHP-A nrPDB 36 0.038 5YLE-A nrPDB 36 0.039 5OLB-A nrPDB 36 0.043 2W5W-A nrPDB 35 0.071 3NVL-A nrPDB 35 0.075 5HI2-A nrPDB 34 0.14 5JTL-E nrPDB 34 0.20 5EGE-A nrPDB 33 0.25 2W9X-A nrPDB 33 0.31 2MLZ-B nrPDB 31 0.95 4BLN-A nrPDB 30 1.9 6FXY-A nrPDB 29 3.9 >1E2S-P nrPDB Length = 489 Score = 672 bits (1734), Expect = 0.0, Method: Composition-based stats. Identities = 488/489 (99%), Positives = 488/489 (99%) Query: 19 RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLT 78 RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSL TPSRAALLT Sbjct: 1 RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLATPSRAALLT 60 Query: 79 GRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPH 138 GRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPH Sbjct: 61 GRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPH 120 Query: 139 QGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLE 198 QGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLE Sbjct: 121 QGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLE 180 Query: 199 ARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAV 258 ARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAV Sbjct: 181 ARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAV 240 Query: 259 GTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFW 318 GTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFW Sbjct: 241 GTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFW 300 Query: 319 PGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPS 378 PGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPS Sbjct: 301 PGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPS 360 Query: 379 YPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGEN 438 YPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGEN Sbjct: 361 YPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGEN 420 Query: 439 YNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPA 498 YNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPA Sbjct: 421 YNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPA 480 Query: 499 CCHCPDPHA 507 CCHCPDPHA Sbjct: 481 CCHCPDPHA 489 >1P49-A nrPDB Length = 562 Score = 445 bits (1145), Expect = e-125, Method: Composition-based stats. Identities = 177/559 (31%), Positives = 250/559 (44%), Gaps = 82/559 (14%) Query: 17 VARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAAL 76 A PNI+L+ ADDLG GD GCYG+ + TPN+D+LA+GG++ T L TPSRAA Sbjct: 2 AASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLATPSRAAF 61 Query: 77 LTGRLPVRMGMYPGV-----LVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVG-- 129 +TGR PVR GM L +S GGLP +E+T A++L +GY T + GKWHLG+ Sbjct: 62 MTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCH 121 Query: 130 --PEGAFLPPHQ--------------------------GFHRFLGIPYSHDQGPCQNLTC 161 + P H GF R + +P L Sbjct: 122 SKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAA 181 Query: 162 FPP--------------------ATPCDGGCDQGLVPIP--LLANLSVEAQPPWLPGLEA 199 G P+ ++ N + QP L Sbjct: 182 LNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQ 241 Query: 200 RYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVG 259 R A + + + PF L + H H FS + FA +S G +GD++ E+D +VG Sbjct: 242 RLTVEAAQFIQ--RNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVG 299 Query: 260 TLMTAIGDLGLLEETLVIFTADNGPETMRMS-----RGGCSGLLRCGKGTTYEGGVREPA 314 ++ + +L L +TL+ FT+D G +S GG +G+ + GK +EGG+R P Sbjct: 300 QILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPG 359 Query: 315 LAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTLDGFDLSPLLLGTG-KSPRQ 371 + WP I G E S++D+ PT+A LAGAPLP + +DG DL PLL G +S + Sbjct: 360 ILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHE 419 Query: 372 SLFFY-PSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHA----SSSLTAHEPP 426 LF Y +Y + VR T +KA FFT + A H S +T H+PP Sbjct: 420 FLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPP 479 Query: 427 LLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGE---DP 483 LL+D+SKDP E L + P + LK +Q + + P Q + P Sbjct: 480 LLFDISKDPRERNPL---TPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKP 536 Query: 484 ALQICCHPGCTPRPACCHC 502 LQ+C C C C Sbjct: 537 WLQLC----CPSTGLSCQC 551 >4FDJ-A nrPDB Length = 502 Score = 441 bits (1133), Expect = e-124, Method: Composition-based stats. Identities = 185/513 (36%), Positives = 262/513 (51%), Gaps = 56/513 (10%) Query: 19 RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLT 78 +PPNI+L+ DD+G+GDLG YG PS TPNLD++AA GL F +FY L +PSRAALLT Sbjct: 3 QPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLXSPSRAALLT 62 Query: 79 GRLPVRMGMYP------GVLVPSS-RGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPE 131 GRLP+R G Y P GG+P E + E+L GY++ + GKWHLG P+ Sbjct: 63 GRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ 122 Query: 132 GAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQ-GLVPIPLLANLSVEAQ 190 F P GF + G P H GP N P P + G NL Sbjct: 123 --FHPLKHGFDEWFGSPNCH-FGPYDNKAR--PNIPVYRDWEMVGRYYEEFPINLKTGE- 176 Query: 191 PPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDS 250 L Y+ A D + R PFFLY+A TH P ++ + F S RG +GD+ Sbjct: 177 ----ANLTQIYLQEALDFIKRQARH-HPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDA 231 Query: 251 LMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRM-SRGGCSGLLRCGKGTTYEGG 309 + E+D ++G ++ + DL + + T V FT+DNG + +GG +G CGK TT+EGG Sbjct: 232 VREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGG 291 Query: 310 VREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTLDGFDLSPLLLGTGK 367 +REPALA+WPGH+ G V+H+L S +DL T ALAG P + +DG +L P LL G+ Sbjct: 292 MREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLL-QGR 350 Query: 368 SPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSD-TTADPAC--HASSSLTAH- 423 + +F+Y + A G++KAHF+T ++ + C S +T H Sbjct: 351 LMDRPIFYY-----RGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHN 405 Query: 424 -----EPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVA 478 + PL++ L +DPGE + L + A+ E +AL ++ + Q A+ P+Q Sbjct: 406 LEDHTKLPLIFHLGRDPGERFPL----SFASAEYQEALSRITSVVQQHQEALV--PAQ-- 457 Query: 479 RGEDPALQICCH-------PGCTPRPACCHCPD 504 P L +C PGC C P+ Sbjct: 458 ----PQLNVCNWAVMNWAPPGCEKLGKCLTPPE 486 >3ED4-A nrPDB Length = 502 Score = 391 bits (1004), Expect = e-109, Method: Composition-based stats. Identities = 155/507 (30%), Positives = 220/507 (43%), Gaps = 84/507 (16%) Query: 16 AVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAA 75 A A+ PN+V+I ADDLGYGDL YGH TPN+D+LA G++FTD+Y P L +PSRA Sbjct: 23 AEAKQPNLVIIMADDLGYGDLATYGHQIVKTPNIDRLAQEGVKFTDYYAPAPLSSPSRAG 82 Query: 76 LLTGRLPVRMGMYPGVLVPSSRG-GLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAF 134 LLTGR+P R G+ +PS + L E+T+A +L A+GY T M GK HL G + Sbjct: 83 LLTGRMPFRTGIRS--WIPSGKDVALGRNELTIANLLKAQGYDTAMMGKLHLNAGGDRTD 140 Query: 135 LPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGL----VPIPLLANLSVEAQ 190 P Q +G YS N F D ++ P L N Sbjct: 141 QPQAQ----DMGFDYS-----LANTAGFVTDATLDNAKERPRYGMVYPTGWLRNG---QP 188 Query: 191 PPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAER--------- 241 P + Y++ D ++ +PFFLY A H P S + + + Sbjct: 189 TPRADKMSGEYVSSEVVNWLDNKKDSKPFFLYVAFTEVHSPLASPKKYLDMYSQYMSAYQ 248 Query: 242 ----------------SGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPE 285 G G + ++ LDA VG ++ I +G + T+VIFT+DNGP Sbjct: 249 KQHPDLFYGDWADKPWRGVGEYYANISYLDAQVGKVLDKIKAMGEEDNTIVIFTSDNGPV 308 Query: 286 TMRMSR------GGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPG-VTHELASSLDLLP 338 T + G + LR K +EGG+R PA+ + H+ G V+ LD +P Sbjct: 309 TREARKVYELNLAGETDGLRGRKDNLWEGGIRVPAIIKYGKHLPQGMVSDTPVYGLDWMP 368 Query: 339 TLAALAGAPLP-NVTLDGFDLSPLLLGTGKSPRQSLFFYPSYP--DEVRGVFAVRTGKYK 395 TLA + LP + T DG L P+L + L F P D+ +A+R G +K Sbjct: 369 TLAKMMNFKLPTDRTFDGESLVPVLEQKALKREKPLIFGIDMPFQDDPTDEWAIRDGDWK 428 Query: 396 AHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGG-------VAGA 448 +P LY+L D E NL+G + G Sbjct: 429 MIIDRNN---------------------KPKYLYNLKSDRYETLNLIGKKPDIEKQMYGK 467 Query: 449 TPEVLQALKQLQLLKAQLDA--AVTFG 473 + + L+KA+ D AVT+G Sbjct: 468 FLKYKTDIDNDSLMKARGDKPEAVTWG 494 >6BIA-A nrPDB Length = 477 Score = 385 bits (988), Expect = e-107, Method: Composition-based stats. Identities = 134/468 (28%), Positives = 209/468 (44%), Gaps = 43/468 (9%) Query: 8 LLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVS 67 L+ + +A + PNI+LI ADDLGY D+G G TPN+D LA G F+D YV Sbjct: 14 LVPRGSHMASEQKPNIILIVADDLGYADVGFNGSKDIITPNIDDLAKSGTSFSDAYVAHP 73 Query: 68 LCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLG 127 C PSRAAL+TGR P ++G + S G+P + ++++L Y TG GKWH+G Sbjct: 74 FCGPSRAALMTGRYPHKIGSQFNLPTRGSNVGVPTDAKFISKLLNENNYFTGALGKWHMG 133 Query: 128 VGPEGAFLPPHQGFHRFLGI-PYSHDQGPCQNLTCFPPATPCDGGCDQGLVPI-PLLANL 185 P+ P +GF + G H+ P Q + G I PL N Sbjct: 134 DTPQH--HPNKRGFDEYYGFLGGGHNYFPDQYQPQYKKQ--KAQGLKNIFEYITPLEHNG 189 Query: 186 SVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYP-QFSGQSFA----- 239 + ++ +R A + + A + PFFLY A + H P Q + A Sbjct: 190 KEVKETQYITDALSR---EAVNFVDKAVNKKHPFFLYLAYNAPHTPLQAKDEDMAMFPNI 246 Query: 240 ERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLR 299 + R + + +D VG L+ A+ + TL++F +DNG + S+G + L+ Sbjct: 247 KNKDRKTYAGMVYAVDRGVGKLVEALKKNNQYDNTLIVFMSDNGGKL---SKGANNFPLK 303 Query: 300 CGKGTTYEGGVREPALAFWPGHIAPGVT-HELASSLDLLPTLAALAGAPL-PNVTLDGFD 357 GKG+T EGG R P L WP H+ G S+LDL PT AALAGA + N LDG + Sbjct: 304 AGKGSTQEGGFRVPMLFHWPKHVPAGKRFSHPVSALDLYPTFAALAGAKVEENQHLDGTN 363 Query: 358 LSPLLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHAS 417 + P + ++P + Y + A+R ++KA Sbjct: 364 MWPAFI-KNENPHKDEPIYALRHRKGYSDAAIRMNQWKAL-------------------- 402 Query: 418 SSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQ 465 +P L+++ D E +++ ++++ +++ Q Sbjct: 403 --KVNQQPWQLFNIENDISEKHDVSKSNKALLTDMVREMEKWSWDNQQ 448 >1FSU-A nrPDB Length = 492 Score = 373 bits (957), Expect = e-103, Method: Composition-based stats. Identities = 142/518 (27%), Positives = 210/518 (40%), Gaps = 87/518 (16%) Query: 18 ARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALL 77 +RPP++V + ADDLG+ D+G +G TP+LD LAAGG+ ++Y L TPSR+ LL Sbjct: 1 SRPPHLVFLLADDLGWNDVGFHG-SRIRTPHLDALAAGGVLLDNYYTQ-PLATPSRSQLL 58 Query: 78 TGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPP 137 TGR +R G+ ++ P +PL+E + ++L GY T M GKWHLG+ + LP Sbjct: 59 TGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKEC-LPT 117 Query: 138 HQGFHRFLGI------PYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQP 191 +GF + G YSH++ C + T C G N+ Sbjct: 118 RRGFDTYFGYLLGSEDYYSHER--CTLIDALN-VTRCALDFRDGEEVATGYKNMYSTNI- 173 Query: 192 PWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYP------QFSGQSFAERSGRG 245 R +A + ++P FLY A H P F + R Sbjct: 174 -----FTKRAIA-----LITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRH 223 Query: 246 PFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTT 305 + + +D AVG + A+ GL T+ IF+ DNG +T+ GG + LR K + Sbjct: 224 HYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTL---AGGNNWPLRGRKWSL 280 Query: 306 YEGGVREPALAFWPGHIAPGVTH-ELASSLDLLPTLAALA-GAPLPNVTLDGFDLSPLLL 363 +EGGVR P GV + EL D LPTL LA G LDGFD+ + Sbjct: 281 WEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTIS 340 Query: 364 GTGKSPRQSLFF----------------------------YPSYPDEVRGVFAVRTGKYK 395 SPR L Y ++ V A+R G +K Sbjct: 341 EGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSV--HAAIRHGNWK 398 Query: 396 AHFFTQGSAHSDTTADPACHASSSLTAHEPP----LLYDLSKDPGENYNLLGGVAGATPE 451 G + P+ + S + + +PP L+D+ +DP E ++L + Sbjct: 399 LLTGYPGCGY--WFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTK 456 Query: 452 VLQALKQLQLLKAQL--------------DAAVTFGPS 475 + L +LQ A +GP Sbjct: 457 L---LSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPW 491 >2QZU-A nrPDB Length = 491 Score = 338 bits (866), Expect = 4e-93, Method: Composition-based stats. Identities = 121/503 (24%), Positives = 190/503 (37%), Gaps = 91/503 (18%) Query: 4 PRSLLLA--LAAGLAVARP---PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLR 58 P++LL L+ GL PN+V I AD +GC G TP+LD+LA+ G+ Sbjct: 6 PQALLTMPILSTGLQAQEKQPTPNLVFIMADQYRGDAIGCIGKEPVKTPHLDKLASEGIN 65 Query: 59 FTDFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVT--VAEVLAARGY 116 FT+ + +P+R L+TG P+ + ++ G+ L + ++VL +GY Sbjct: 66 FTNAISSYPVSSPARGMLMTGMYPIGSKVTGNCNSETAPYGVELSQNARCWSDVLKDQGY 125 Query: 117 LTGMAGKWHL--------------GVGPEGAFLPPHQ--GFHRFLGI-PYSHDQGPCQNL 159 G GKWHL G + PP + GF ++ Y + P Sbjct: 126 NMGYIGKWHLDAPYKPYVDTYNNRGKVAWNEWCPPERRHGFDHWIAYGTYDYHLKPMYWN 185 Query: 160 TCFP-----------------PATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLE---A 199 T P A G P L+ +++ P G E Sbjct: 186 TTAPRDSFYYVNQWGPEYEASKAIEYINGQKDQKQPFALVVSMN-----PPHTGYELVPD 240 Query: 200 RYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVG 259 RY DL +A + RP + G F R+ + + +D VG Sbjct: 241 RYKEIYKDLDVEALCKGRPDIPAKGTE-------MGDYF--RNNIRNYYACITGVDENVG 291 Query: 260 TLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWP 319 ++ A+ L + T+V+FT+D+G GK YE +R P + WP Sbjct: 292 RIIEALKQNNLFDNTIVVFTSDHGICMGAHE--------NAGKDIFYEESMRIPMILSWP 343 Query: 320 GHIAPGVTHELASSL-DLLPTLAALAGA--PLPNVTLDGFDLSP-LLLGTGKSPRQSLFF 375 I P + L + DL PTL ++ G +P T+ FDLS +L G K ++ Sbjct: 344 DQIKPRKSDPLMIAFADLYPTLLSMMGFSKEIPE-TVQTFDLSNEVLTGKNKKDLVQPYY 402 Query: 376 YPSYPDEVRGVFAVRTGKYK-AHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKD 434 + + + G +RT +Y A T G + +L+D + D Sbjct: 403 FVKFDNHATGYRGLRTDRYTYAVHATDGKIDNV-------------------ILFDRTND 443 Query: 435 PGENYNLLGGVAGATPEVLQALK 457 P E N+ T + LK Sbjct: 444 PHEMNNIASQQLKLTHTFNRQLK 466 >4UPI-A nrPDB Length = 576 Score = 324 bits (829), Expect = 6e-89, Method: Composition-based stats. Identities = 122/563 (21%), Positives = 189/563 (33%), Gaps = 121/563 (21%) Query: 9 LALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSL 68 + ++ + + + NI+ I D L + L CYGH TPN+D+LA G+RFT+ YV ++ Sbjct: 17 VPNSSSVPMTQNRNILWIMCDQLRFDYLSCYGHERLNTPNIDKLAKRGVRFTNAYVQATV 76 Query: 69 CTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLE--EVTVAEVLAARGYLTGMAGKWH- 125 PSR + TGR G S++ G+PL E T+ + L G + GK H Sbjct: 77 AGPSRMSAYTGRYVRSHG--------STQNGIPLRVGEPTLGDHLRDVGMRNVLIGKTHM 128 Query: 126 ---------LGVGPEG--AFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQ 174 LG+ P+ GF F H G + + G Q Sbjct: 129 RPDLDGMKRLGIDPDSEIGARVGEGGFDAFDRDDGVHPTGYRKKEPAYNDYLRHAGF--Q 186 Query: 175 GLVPIPLLANLSV----EAQPPWL------------PGLEARYMA-FAHDLMADAQRQDR 217 P AN + E Q WL E YM A + M A++ R Sbjct: 187 AENPWEFWANSAEGKGGENQSGWLLTHADKPARVPEEHSETAYMTRRAMEFMEAAEKDGR 246 Query: 218 PFFLYYASHHTHYP--------------------------------------QFSGQSFA 239 P+ + + H+P + ++FA Sbjct: 247 PWCAHLSYIKPHWPYIVPAPYHDMFGPDDVKPAVRSDEELKAAHPLFKAMTEEVYSRNFA 306 Query: 240 ERSGRGP----FGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCS 295 R + + ++D +G L + + GL E T+++FTAD+G G Sbjct: 307 RDEVREKVIPAYMGLIKQIDDQLGQLFAFMQERGLDENTMIVFTADHGDYLGDHWMG--- 363 Query: 296 GLLRCGKGTTYEGGVREPALAFWPGHIAPG----VTHELASSLDLLPTLAALAGAPLPNV 351 K YE + P + + P A V+ L +DL PT AG P Sbjct: 364 -----EKYLFYEAAAKVPLIIYDPSDKADATRGTVSDALVEMIDLAPTFVDYAGGVPPMH 418 Query: 352 TLDGFDLSPLLLGTGKSPRQSLFF----YPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSD 407 L+G L PLL S + F Y + P ++ ++ + F Sbjct: 419 ILEGKSLLPLLHDDDSSWDRQYVFSELDYSNLPARLKLGRDIQDCRATMVFDG------- 471 Query: 408 TTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQL- 466 P+L+DL DP E +L + ++L Sbjct: 472 -------RYKLVEVMGFAPILFDLEVDPDELKDLGRDPSAEEVR-----QRLTSALDAWH 519 Query: 467 --DAAVTFGPSQVARGEDPALQI 487 R DP L+ Sbjct: 520 RNTRQRITKSDAAYRALDPVLRE 542 >4CXU-A nrPDB Length = 536 Score = 319 bits (817), Expect = 2e-87, Method: Composition-based stats. Identities = 137/552 (24%), Positives = 207/552 (37%), Gaps = 143/552 (25%) Query: 17 VARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAAL 76 +++ PN ++I ADDLG+ D+G +G TPNLD LA GLR TDF+ + +P+R+ L Sbjct: 1 MSKRPNFLVIVADDLGFSDIGTFGGE-IATPNLDALAIAGLRLTDFHTASA-ASPTRSML 58 Query: 77 LTG--RLPVRMGMYPGVLVPSSRGG------LPLEEVTVAEVLAARGYLTGMAGKWHLGV 128 LTG +G L P G L V + E+L GY T MAGKWHLG+ Sbjct: 59 LTGTDHHIAGIGTMAEALTPELEGKPGYEGHLNERVVALPELLREAGYQTLMAGKWHLGL 118 Query: 129 GPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVE 188 PE P +GF R + N F P P D + L P L + E Sbjct: 119 KPEQT--PHARGFERSFAL-----LPGAANHYGFEP--PYDESTPRILKGTPAL-YVEDE 168 Query: 189 AQPPWLPGLEARYMAFAHDLMADAQRQD--RPFFLYYASHHTHYPQFSGQSFAER-SGRG 245 LP AF L+ + +D RPFF Y H+P + + E+ GR Sbjct: 169 RYLDTLPEGFYSSDAFGDKLLQYLKERDQSRPFFAYLPFSAPHWPLQAPREIVEKYRGRY 228 Query: 246 P-----------------------------------------------------FGDSLM 252 + + Sbjct: 229 DAGPEALRQERLARLKELGLVEADVEAHPVLALTREWEALEDEERAKSARAMEVYAAMVE 288 Query: 253 ELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMR--------------MSRGGCSGLL 298 +D +G ++ + G L+ T V+F +DNG E + R + L Sbjct: 289 RMDWNIGRVVDYLRRQGELDNTFVLFMSDNGAEGALLEAFPKFGPDLLDFLDRHYDNSLE 348 Query: 299 RCGKGTTY-----------------------EGGVREPALAFWPGHIAPG-VTHELASSL 334 G+ +Y +GG+R PAL +P G ++H A+ + Sbjct: 349 NIGRANSYVWYGPRWAQAATAPSRLYKAFTTQGGIRVPALVRYPRLSRQGAISHAFATVM 408 Query: 335 DLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDE--------VRGV 386 D+ PTL LAG P G +++ G+S L + + G+ Sbjct: 409 DVTPTLLDLAGVRHPGKRWRGREIA---EPRGRSWLGWLSGETEAAHDENTVTGWGLFGM 465 Query: 387 FAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGGVA 446 A+R G +KA + PA ++ LYDL++DPGE ++L Sbjct: 466 RAIRQGDWKAVYL------------PAPVGPATWQ------LYDLARDPGEIHDLADSQP 507 Query: 447 GATPEVLQALKQ 458 G E+++ K+ Sbjct: 508 GKLAELIEHWKR 519 >5G2T-A nrPDB Length = 489 Score = 311 bits (795), Expect = 6e-85, Method: Composition-based stats. Identities = 107/472 (22%), Positives = 166/472 (35%), Gaps = 90/472 (19%) Query: 14 GLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSR 73 GL PN ++I D L +G YG T +D++A+ G+ F++ YV L PSR Sbjct: 17 GLRQQEKPNFLIIQCDHLTQRVVGAYGQTQGCTLPIDEVASRGVIFSNAYVGCPLSQPSR 76 Query: 74 AALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGA 133 AAL +G +P + + P + LP T+ + + GY GK H +G Sbjct: 77 AALWSGMMPHQTNVRSNSSEPVN-TRLPENVPTLGSLFSESGYEAVHFGKTH-DMGSLRG 134 Query: 134 FLPPHQGFHRFLG--IPYSHDQ----GPCQNLTCF---PPATP--CDGGCDQGLV----- 177 F F P ++D G C++ + PP P C Sbjct: 135 FKHKEPVAKPFTDPEFPVNNDSFLDVGTCEDAVAYLSNPPKEPFICIADFQNPHNICGFI 194 Query: 178 --------------PIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYY 223 P+P L + +P +Y+ +H M A + + +Y Sbjct: 195 GENAGVHTDRPISGPLPELPDNFDVEDWSNIP-TPVQYICCSHRRMTQAAHWNEENYRHY 253 Query: 224 ASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNG 283 + HY + + V +++ A+ T+V+ AD+G Sbjct: 254 IAAFQHYTKM--------------------VSKQVDSVLKALYSTPAGRNTIVVIMADHG 293 Query: 284 PETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPG--HIAPGVTHELAS-SLDLLPTL 340 G S + + Y+ P + PG V H L +LDLLPTL Sbjct: 294 -------DGMASHRMVTKHISFYDEMTNVPFIFAGPGIKQQKKPVDHLLTQPTLDLLPTL 346 Query: 341 AALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRGVFA----VRTGKYKA 396 LAG +P G L+P L G K + + + E V VR +YK Sbjct: 347 CDLAGIAVP-AEKAGISLAPTLRGE-KQKKSHPYVVSEWHSEYEYVTTPGRMVRGPRYKY 404 Query: 397 HFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGA 448 + +G+ LYD+ KDPGE NL + Sbjct: 405 THYLEGNGEE---------------------LYDMKKDPGERKNLAKDPKYS 435 >4MHX-A nrPDB Length = 510 Score = 302 bits (772), Expect = 3e-82, Method: Composition-based stats. Identities = 145/571 (25%), Positives = 201/571 (35%), Gaps = 156/571 (27%) Query: 4 PRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFY 63 P L L GL ARP N +L+ ADD G+ + G Y + + TP+LD LA L F + + Sbjct: 6 PACCALLLVLGLCRARPRNALLLLADDGGF-ESGAYNNSAIATPHLDALARRSLLFRNAF 64 Query: 64 VPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGK 123 VS +PSRA+LLTG + GMY G+ + ++ +L+ G TG+ GK Sbjct: 65 TSVSSSSPSRASLLTGLPQHQNGMY-GLHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGK 123 Query: 124 WHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLA 183 H VGPE + Y+ + G + + + I LL Sbjct: 124 KH--VGPETVYP---------FDFAYTEENGSVLQV-------------GRNITRIKLLV 159 Query: 184 NLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTH-----YPQFSGQSF 238 ++ Q DRPFFLY A H H PQ+ +F Sbjct: 160 RKFLQTQ------------------------DDRPFFLYVAFHDPHRCGHSQPQYG--TF 193 Query: 239 AERSGRGPFG-------------------------------------DSLMELDAAVGTL 261 E+ G G G ++ +D VG + Sbjct: 194 CEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLV 253 Query: 262 MTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGH 321 + + D G+L +TLVIFT+DNG G+ Y G EP L P H Sbjct: 254 LQELRDAGVLNDTLVIFTSDNGI------------PFPSGRTNLYWPGTAEPLLVSSPEH 301 Query: 322 IAPG--VTHELASSLDLLPTLAALAGAPLPNV--------TLDGFDLSPLLLGTGKSPRQ 371 V+ S LDL PT+ P P+ L G L P L P Sbjct: 302 PKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAE---PLW 358 Query: 372 SLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGS--------AHSDTTADPACHASSSLTAH 423 + F EV + +R+ +++ HF + D P + T Sbjct: 359 ATVFGSQSHHEVTMSYPMRSVQHR-HFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTA 417 Query: 424 EPPL----------------LYDLSKDPGENYNLLGGVAGATPEVLQALKQL--QLLKAQ 465 P LYD S+DP E NL P Q L+ L QL K Q Sbjct: 418 GQPTGWYKDLRHYYYRARWELYDRSRDPHETQNLA-----TDPRFAQLLEMLRDQLAKWQ 472 Query: 466 LDAAVTFGPSQVARGEDPALQICCHPGCTPR 496 + T P A D L+ P C P Sbjct: 473 WE---THDPWVCA--PDGVLEEKLSPQCQPL 498 >2VQR-A nrPDB Length = 543 Score = 286 bits (731), Expect = 2e-77, Method: Composition-based stats. Identities = 105/527 (19%), Positives = 165/527 (31%), Gaps = 100/527 (18%) Query: 19 RPPNIVLIFADDLGYG----DLGCYGH-PSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSR 73 R N++LI D L G TPNLD+L G+ F + P+R Sbjct: 31 RKKNVLLIVVDQWRADFVPHVLRADGKIDFLKTPNLDRLCREGVTFRNHVTTCVPAGPAR 90 Query: 74 AALLTGRLPVRMGMYPGVLVPSSRGGLPLEEV--TVAEVLAARGYLTGMAGKWHLGVGPE 131 A+LLTG + + + +PL++ + + L GY + G P Sbjct: 91 ASLLTGLYLMNHR--------AVQNTVPLDQRHLNLGKALRGVGYDPALIGYTTTVPDPR 142 Query: 132 GAFLPPHQ---------GFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLL 182 + GFH + + G + P +P Sbjct: 143 TTSPNDPRFRVLGDLMDGFHPVGAFEPNME-GYFGWVAQNGFDLP--EHRPDIWLPEGED 199 Query: 183 ANLSVEAQPPWLPGLEARYMAFAHDLMADAQ-RQDRPFFLYYASHHTHYP---------- 231 A +P +P + F + + R +PFFL+ + H P Sbjct: 200 AVAGATDRPSRIPKEFSDSTFFTERALTYLKGRDGKPFFLHLGYYRPHPPFVASAPYHAM 259 Query: 232 -----------------------------------------QFSGQSFAE---RSGRGPF 247 + SG + E R R + Sbjct: 260 YRPEDMPAPIRAANPDIEAAQHPLMKFYVDSIRRGSFFQGAEGSGATLDEAELRQMRATY 319 Query: 248 GDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYE 307 + E+D +G + + + + G ++TL+IFT+D+G + G LL GK + Sbjct: 320 CGLITEVDDCLGRVFSYLDETGQWDDTLIIFTSDHGEQL------GDHHLL--GKIGYND 371 Query: 308 GGVREPALAFWPGHIAPG--VTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGT 365 R P + G A + S+D++PT+ G +P+ DG L P L Sbjct: 372 PSFRIPLVIKDAGENARAGAIESGFTESIDVMPTILDWLGGKIPHAC-DGLSLLPFLSEG 430 Query: 366 GKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEP 425 ++ Y + R V+ F G A P Sbjct: 431 RPQDWRTELHY---EYDFRDVYYSEPQS----FLGLGMNDCSLCVIQDERYKYVHFAALP 483 Query: 426 PLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTF 472 PL +DL DP E NL A A A K L D +T Sbjct: 484 PLFFDLRHDPNEFTNLADDPAYAALVRDYAQKALSWRLKHADRTLTH 530 >4UPH-A nrPDB Length = 547 Score = 283 bits (724), Expect = 1e-76, Method: Composition-based stats. Identities = 127/542 (23%), Positives = 191/542 (35%), Gaps = 103/542 (19%) Query: 2 GAPRSLLLALAAGLAVA-RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT 60 G P S+ + + + PN++LI AD L GH S TPN+D LA G+ FT Sbjct: 25 GDPSSMPNPTSIEWRPSGKRPNVLLISADQWRGDCLSAVGHASVKTPNVDALAQDGVLFT 84 Query: 61 DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAAR--GYLT 118 + + +P+RA L TG + + R G PL+ LAAR GY Sbjct: 85 RHFAGTAPASPARATLYTGLYQMNHRV--------CRNGSPLDARFDNLALAARRGGYDP 136 Query: 119 GMAGKWHLGVGPEGAFLPPHQ---------GFHRFLGIPYSHDQGPCQNLT--CFPPATP 167 + G P G GF +P H++ L P AT Sbjct: 137 TLFGYTDTAPDPRGMDPNDPHLTTYEGVLPGFSARQLLP-EHEKQWLSWLRSRGHPEATS 195 Query: 168 CDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHH 227 D G P + P E + A + + QD P+F + + Sbjct: 196 RDIHIPVGATP------GEISDVAPAYSKDETQTAFLAGEFIRWLGEQDAPWFAHVSFLR 249 Query: 228 TH----YPQFSGQSFAERSG---------------------------------------- 243 H P+ + F G Sbjct: 250 PHPPFSVPEPYNRMFTPSDGPAFARAANREAEQAVHPLLAFALPLIGKDSFIYGGEGSAS 309 Query: 244 ----------RGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGG 293 R + + E+D +G + A+ ++G ++TL+IFT+D+ G Sbjct: 310 DWTSEDLSAIRAIYYGMIAEVDTQLGRIWQALKNVGAWDDTLIIFTSDH------AEMMG 363 Query: 294 CSGLLRCGKGTTYEGGVREPALAFWPGHI--APGVTHELASSLDLLPTLAALAGAPLPNV 351 +L GKG ++G P + PGH A S+ D+ PTL G +P+ Sbjct: 364 DHWML--GKGGFFDGSYHVPLVIRDPGHPGGAGRQVERFTSAADIFPTLCDRLGL-VPDN 420 Query: 352 TLDGFDLSPLLL-GTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTA 410 LDG L P L G + R + F+ + D + G+ + HF + +A + Sbjct: 421 HLDGGTLVPFLEGGEPEGWRDAAFWEFDFRD-------IAKGEAERHFGLKSNACNLAVI 473 Query: 411 DPACHASSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAV 470 A PPLLYDL+KDP E N+ A + A K L L LD + Sbjct: 474 RDERFKYVHF-AGLPPLLYDLAKDPMELTNVAADADYAAVRLGYAEKLLSLRAQHLDQTL 532 Query: 471 TF 472 + Sbjct: 533 AY 534 >4UG4-A nrPDB Length = 515 Score = 283 bits (723), Expect = 1e-76, Method: Composition-based stats. Identities = 125/505 (24%), Positives = 182/505 (36%), Gaps = 105/505 (20%) Query: 20 PPNIVLIFADDLGYGDLGCYGHPS-STTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLT 78 PNI++I D L G L G PNL LA RF + Y LC P+RA+ + Sbjct: 8 KPNILIIMVDQLN-GKLFPDGPADFLHAPNLKALAKRSARFHNNYTSSPLCAPARASFMA 66 Query: 79 GRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPH 138 G+LP R +Y + +P T A L GY T ++GK H VGP+ Sbjct: 67 GQLPSRTRVYDNA--AEYQSSIP----TYAHHLRRAGYYTALSGKMHF-VGPDQL----- 114 Query: 139 QGFHRFLGIP-YSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGL 197 GF L Y D G + L + + Q + Sbjct: 115 HGFEERLTTDIYPADFG---WTPDYRKPGERIDWWYHNLGSVTGAGVAEITNQMEYDD-- 169 Query: 198 EARYMAFAHDLMADAQRQD---RPFFLYYASHHTHYPQFSGQSF---------------- 238 E ++A + D RP+ L + H H P + + F Sbjct: 170 EVAFLANQKLYQLSRENDDESRRPWCLTVSFTHPHDPYVARRKFWDLYEDCEHLTPEVGA 229 Query: 239 ---------------------------AERSGRGPFGDSLMELDAAVGTLMTAIGDLGLL 271 R R + ++ LD VG L+ + +L Sbjct: 230 IPLDEQDPHSQRIMLSCDYQNFDVTEENVRRSRRAYFANISYLDEKVGELIDTLTRTRML 289 Query: 272 EETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGVTHELA 331 ++TL++F +D+G G GL K +EG R P + PG IAPG+ Sbjct: 290 DDTLILFCSDHG------DMLGERGL--WFKMNFFEGSARVPLMIAGPG-IAPGLHLTPT 340 Query: 332 SSLDLLPTLAALAGAPLPNVT--LDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRGVFAV 389 S+LD+ PTLA LAG L V DG L P++ G ++ + + + + A+ Sbjct: 341 SNLDVTPTLADLAGISLEEVRPWTDGVSLVPMVNGVERT--EPVLMEYAAEASYAPLVAI 398 Query: 390 RTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLL----GGV 445 R GK+K + A +P L+DL DP E NL G V Sbjct: 399 REGKWKYVY----------------------CALDPEQLFDLEADPLELTNLAENPRGPV 436 Query: 446 AGATPEVLQALKQLQLLKAQLDAAV 470 AT + ++ DAAV Sbjct: 437 DQATLTAFRDMRAAHWDMEAFDAAV 461 >2W8S-A nrPDB Length = 543 Score = 281 bits (717), Expect = 7e-76, Method: Composition-based stats. Identities = 112/523 (21%), Positives = 171/523 (32%), Gaps = 94/523 (17%) Query: 20 PPNIVLIFADDLGYGDLG----CYGHPS-STTPNLDQLAAGGLRFTDFYVPVSLCTPSRA 74 N++LI D + G TPNLD+L GL F + P+RA Sbjct: 32 RKNVLLIVVDQWRADFIPHLMRAEGREPFLKTPNLDRLCREGLTFRNHVTTCVPGGPARA 91 Query: 75 ALLTGRLPVRMGMYPGVLVPSSRGGLPLEEV--TVAEVLAARGYLTGMAGKWHL------ 126 +LLTG + + + +PL++ + + L A GY + G Sbjct: 92 SLLTGLYLMNHR--------AVQNTVPLDQRHLNLGKALRAIGYDPALIGYTTTTPDPRT 143 Query: 127 ----------------GVGPEGAFLPPHQGFHRF-----LGIP----------YSHDQGP 155 G GAF P +G+ + +P H Sbjct: 144 TSARDPRFTVLGDIMDGFRSVGAFEPNMEGYFGWVAQNGFELPENREDIWLPEGEHSVPG 203 Query: 156 CQNLTCFPPATPCDGGC--DQGLVPIP-------LLANLSVEAQPPWLPGLEARYMAFAH 206 + P D ++ L + L PP++ M A Sbjct: 204 ATDKPSRIPKEFSDSTFFTERALTYLKGRDGKPFFLHLGYYRPHPPFVASAPYHAMYKAE 263 Query: 207 DLMA-------DAQRQDRPFFLYYASH-----HTHYPQFSGQSFAE---RSGRGPFGDSL 251 D+ A DA+ P +Y H H + SG + E R R + + Sbjct: 264 DMPAPIRAENPDAEAAQHPLMKHYIDHIRRGSFFHGAEGSGATLDEGEIRQMRATYCGLI 323 Query: 252 MELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVR 311 E+D +G + + + G ++TL+IFT+D+G + G LL GK R Sbjct: 324 TEIDDCLGRVFAYLDETGQWDDTLIIFTSDHGEQL------GDHHLL--GKIGYNAESFR 375 Query: 312 EPALAFWPGHI--APGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSP 369 P + G A + + S+D++PT+ G P DG L P L S Sbjct: 376 IPLVIKDAGQNRHAGQIEEGFSESIDVMPTILEWLGGETPRAC-DGRSLLPFLAEGKPSD 434 Query: 370 RQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLY 429 ++ Y + R VF + + A PPL + Sbjct: 435 WRTELHY---EFDFRDVFYDQPQN----SVQLSQDDCSLCVIEDENYKYVHFAALPPLFF 487 Query: 430 DLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTF 472 DL DP E NL G A A A K L + D +T Sbjct: 488 DLKADPHEFSNLAGDPAYAALVRDYAQKALSWRLSHADRTLTH 530 >4UPL-A nrPDB Length = 569 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 100/529 (18%), Positives = 164/529 (31%), Gaps = 110/529 (20%) Query: 22 NIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGRL 81 NI+ I D L + L CYGH + TP++D+LAA G+RF Y+ +C SR + TGR Sbjct: 19 NILFIMFDQLRWDYLSCYGHKTLNTPHIDRLAAKGVRFDRAYIQSPICGSSRMSTYTGRY 78 Query: 82 PVRMGMYPGVLVPSSRGGLPLE--EVTVAEVLAARGYLTGMAGKWHLGVGPEG------- 132 G +S G+PL+ E+T+ + L A G + GK H+ EG Sbjct: 79 VHSHG--------ASWNGIPLKVGEMTMGDHLRAAGMGCWLVGKTHMRADEEGMARLGLE 130 Query: 133 ------------AFLPPHQ-------GFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCD 173 F + G + + + + P + Sbjct: 131 PDSLIGARVAECGFDVFERDDGMLPEGPDGYYDPDGAKEYNKFLRAKGYESDNPWHDFAN 190 Query: 174 QGLVPIP------LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHH 227 GL L N + A + A + + P+ + + Sbjct: 191 SGLDDEGNVQSGWFLKNATRPANIAEEDSETPYLTSRAMEFIEQQTG---PWCCHLSYIK 247 Query: 228 THYPQFSGQSFAERSGRGP----------------------------------------- 246 H+P + +A G Sbjct: 248 PHWPYIVPEPYASMFGPEHVQDVVRSDSERQNAHPLFKAFMDTKVGEAFSRQEVRDAVIP 307 Query: 247 -FGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTT 305 + + + D +G L + D G +++T+++ T+D+G G K Sbjct: 308 AYMGLIKQADDQMGRLFKWLEDTGRMQDTMIVLTSDHGDFLGDHWMG--------EKTFF 359 Query: 306 YEGGVREPALAFWPG----HIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPL 361 ++ R P + + P V L S+DL PT AG L+G L P+ Sbjct: 360 HDASTRVPLIIYDPRPEADATRGSVCDALVESIDLAPTFVEAAGGKPAMHILEGESLIPI 419 Query: 362 LLG-TGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSL 420 L G + R + + + + F Sbjct: 420 LHGARDHTLRDHVICEYDFSASPIAHLNDISVRQAVMFMVADKNW----------KLIHF 469 Query: 421 TAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAA 469 A P+L+DL DP E +L G A A K + + Q Sbjct: 470 EADPRPMLFDLKNDPQELVDLGGDPAHADVIAGMYDKLFRWTRRQSQRT 518 >4UPK-A nrPDB Length = 538 Score = 215 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 108/517 (20%), Positives = 168/517 (32%), Gaps = 84/517 (16%) Query: 16 AVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAA 75 ++ R N++ I D L L P+L LA + F Y + C PSRA+ Sbjct: 29 SMGRQSNVLFIIIDQLRADCLWGALADHVELPHLRALAQDAVSFRRHYSVTNPCGPSRAS 88 Query: 76 LLTGRLPVRMGMYPGVLVPSSRGGLPLEEVT--VAEVLAARGYLTGMAGKWHLGVGPE-- 131 +LTG+ + S R G PL T +A + GYL + G P Sbjct: 89 ILTGQYAMNHR--------SVRNGTPLRHDTPNIATEMRKAGYLPLLFGYTDTSQDPRAY 140 Query: 132 -------GAFLPPHQGFHRFLGI--------------------PYSHDQGPCQNLTCFP- 163 + P +GFH + Y+ P + P Sbjct: 141 DANDPALKTYEFPMRGFHEVTEMRLEMSYPWQSHLKNRGYAFDDYAQVYVPRPDADGTPR 200 Query: 164 ---PATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEAR-----------YMAFAHDLM 209 PA D + LAN+ A W L Y Sbjct: 201 LNGPAMYRAEDSDTAFLTDQFLANMPAWAGQNWFAHLTYIRPHPPLVAPAPYNTMYDPAK 260 Query: 210 A---------DAQRQDRPFF-LYYASHHTHY-----PQFSGQSFAERSGRGPFGDSLMEL 254 D + + PFF P ++ R + E+ Sbjct: 261 LPLPARLPGRDDETAEHPFFGPATRYSSPASFVLGFPDLEPTDETIQTLRAVYLGLATEV 320 Query: 255 DAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPA 314 D +G ++ + + G ++TL++ TAD+G G GK T Y+ P Sbjct: 321 DTHIGRVIAHLKETGQYDDTLIVVTADHG------EMLGDRH--SWGKMTVYDAAYHTPL 372 Query: 315 LAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLF 374 + PG V S+DL+PT+ G +PN +DG L P L G S + Sbjct: 373 IIRAPGCKPGHVVEAPTESIDLMPTILDWVGQEIPNA-VDGRSLRPFLTGEAPSDWRQYS 431 Query: 375 FYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKD 434 F E+ + ++ F SA + A A PP+L+D + Sbjct: 432 F-----SELDISEPLDPTLWQQEFGFGPSAGAVAILRDARFTLVEFAADLPPMLFDHQGE 486 Query: 435 PGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVT 471 GE N+ G A A + + L+ +D ++ Sbjct: 487 -GEFRNVAGDPAHAADLARLSRQMLRHRMRNMDHTLS 522 >6IOZ-A nrPDB Length = 517 Score = 203 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 112/543 (20%), Positives = 172/543 (31%), Gaps = 150/543 (27%) Query: 22 NIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGRL 81 N++LI DDL LGCYG +PN+DQLA+ L F + + ++ PSR + LTGR Sbjct: 5 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVAAPSRVSFLTGRR 63 Query: 82 PVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGK-WHLGVGPEGAFLPPHQG 140 P +Y G T+ + GY+T GK +H G+ Sbjct: 64 PDTTRLYDFNSYWRVHAG---NFSTIPQYFKENGYVTMSVGKVFHPGISS---------- 110 Query: 141 FHRFLGIPYSHDQGPCQ-NLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQP-PWLPGLE 198 + PYS P + + C G G + LL + V P LP Sbjct: 111 -NHTDDSPYSWSFPPYHPSSEKYENTKTCRG--PDGELHANLLCPVDVLDVPEGTLPD-- 165 Query: 199 ARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE------------------ 240 + A L+ + PFFL H H P + F + Sbjct: 166 KQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDG 225 Query: 241 -----------------------------------RSGRGPFGDSLMELDAAVGTLMTAI 265 R R + S+ LD VG L++A+ Sbjct: 226 LPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSAL 285 Query: 266 GDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHI--- 322 DL L T++ FT+D+G G G K + ++ P + + PG Sbjct: 286 DDLQLANSTIIAFTSDHG------WALGEHG--EWAKYSNFDVATHVPLIFYVPGRTASL 337 Query: 323 ----------------------APGVTHELASSLDLLPTLAALAGAPLPNV--------- 351 + +L + L PTLA LAG +P Sbjct: 338 PEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHVE 397 Query: 352 -TLDGFDLSPLLLGTG-------KSPRQSLFFYPSYPD------------EVRGV----F 387 +G +L + L Y YP ++ + + Sbjct: 398 LCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSDKPSLKDIKIMGY 457 Query: 388 AVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLGGVAG 447 ++RT Y+ D S + A E LY + DP +++N+ G Sbjct: 458 SIRTIDYRYT------VWVGFNPDEFLANFSDIHAGE---LYFVDSDPLQDHNMYNDSQG 508 Query: 448 ATP 450 Sbjct: 509 GDL 511 >5G2V-A nrPDB Length = 534 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 73/396 (18%), Positives = 132/396 (33%), Gaps = 60/396 (15%) Query: 79 GRLPVRMGMYPGVLVPSSRGGLPLEEVTVA---EVLAARGYLTGMAGKWHLGVGPEGAFL 135 G+ V G ++ + L + + M HLG+ F Sbjct: 159 GKHIVEKGYATDIITDKAINFLENRDKNKPFCMMYHQKAPHRNWMPAPRHLGIFNNTIFP 218 Query: 136 PPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCD-QGLVPIPLLANLSVEAQPPWL 194 P F + G +G D + L +L + + + Sbjct: 219 EPANLFDDYEG------RGKAAREQDMSIEHTLTNDWDLKLLTREEMLKDTTNRLYSVYK 272 Query: 195 PGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMEL 254 + + A Y Q+ + +++ + Sbjct: 273 RMPSEVQDKWDSAYAQRIAEYRKGDLKGKALISWKYQQYM----------RDYLATVLAV 322 Query: 255 DAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPA 314 D +G L+ + +G L+ T++++T+D G G G K YE R P Sbjct: 323 DENIGRLLNYLEKIGELDNTIIVYTSDQGFFL------GEHGWF--DKRFMYEECQRMPL 374 Query: 315 LAFWPGHIAPGV-THELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSP---- 369 + +P I G + ++ ++D PT AG +P+ + G L P+L GK+P Sbjct: 375 IIRYPKAIKAGSTSSAISMNVDFAPTFLDFAGVEVPS-DIQGASLKPVLENEGKTPADWR 433 Query: 370 RQSLFFYPSYPDE--VRGVFAVRTGKYK-AHFFTQGSAHSDTTADPACHASSSLTAHEPP 426 + + + Y YP E V+ + +RT +K HF+ Sbjct: 434 KAAYYHYYEYPAEHSVKRHYGIRTQDFKLIHFYNDIDEWE-------------------- 473 Query: 427 LLYDLSKDPGENYNLLGGVAGA--TPEVLQALKQLQ 460 +YD+ DP E N+ G A E++Q L++ Q Sbjct: 474 -MYDMKADPREMNNIFGKAEYAKKQKELMQLLEETQ 508 Score = 172 bits (434), Expect = 4e-43, Method: Composition-based stats. Identities = 59/259 (22%), Positives = 91/259 (35%), Gaps = 38/259 (14%) Query: 17 VARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAAL 76 + PNI+ + DD + CYG TPN+D++A G+RF + Y +L PSRA + Sbjct: 25 ETKRPNIIFMMTDDHTTQAMSCYGGNLIQTPNMDRIANEGIRFDNCYAVNALSGPSRACI 84 Query: 77 LTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLP 136 LTG+ G S+ G ++ T ++L GY T M GKWHL P Sbjct: 85 LTGKFSHENGFTDNA---STFNG---DQQTFPKLLQQAGYQTAMIGKWHLISEP------ 132 Query: 137 PHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPG 196 QGF + + H+QG + + G + G Sbjct: 133 --QGFDHWSILSGQHEQGDYYDPD----------FWEDGKHIVE--------------KG 166 Query: 197 LEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDA 256 + + + +++PF + Y H F + D Sbjct: 167 YATDIITDKAINFLENRDKNKPFCMMYHQKAPHRNWMPAPRHLGIFNNTIFPEPANLFDD 226 Query: 257 AVGTLMTAIGDLGLLEETL 275 G A +E TL Sbjct: 227 YEGRGKAAREQDMSIEHTL 245 >3LXQ-A nrPDB Length = 450 Score = 103 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 69/362 (19%), Positives = 113/362 (31%), Gaps = 63/362 (17%) Query: 17 VARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAAL 76 + N+V++ + LG +G G TPNLD+L G +FT Y + A+ Sbjct: 82 QGKRKNLVILLQESLGAQFVGSLGGLPL-TPNLDELMQEGWQFTQMYATGTRSVRGIEAV 140 Query: 77 LTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLP 136 TG P + S+ G T+A++L +GY T G E F Sbjct: 141 TTGFPPSPSRAVVKLS--KSQTGFF----TIADLLKEQGYHTQFI------YGGEANFDN 188 Query: 137 PHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPG 196 F G I N + Sbjct: 189 MKTFF------------------------------FGNGFDQIVEEKNYTNPGFVGSWGV 218 Query: 197 LEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE--RSGRGPFGDSLMEL 254 + A + + D+PFF + H P + E S +++ Sbjct: 219 SDEDLYNKADEEFERLSKGDKPFFSLVFTSSNHSPYEYPEGKIEQYDSEHMTRNNAVKYS 278 Query: 255 DAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPA 314 D A+GT ++T+ I AD+ + PA Sbjct: 279 DYALGTFFDKAKKSSYWDDTIFIVIADHDARVFGANLVPVKH-------------FHIPA 325 Query: 315 LAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLF 374 L I P +A+++D+ PTL +L G + G DL+ L + +++ Sbjct: 326 LIIG-KDIQPRKDDRIANNIDMPPTLLSLIGVDAKTPMI-GRDLTKPL---AREDERAMM 380 Query: 375 FY 376 Y Sbjct: 381 QY 382 >4UOP-A nrPDB Length = 442 Score = 98.8 bits (244), Expect = 5e-21, Method: Composition-based stats. Identities = 65/416 (15%), Positives = 124/416 (29%), Gaps = 62/416 (14%) Query: 17 VARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRA-- 74 A+ N++++ + + S TP LD L + F+ VS + A Sbjct: 54 AAKGKNLIIVQLESFQRNLTNVKINGQSITPTLDGLQNETMYSNQFFQTVSKSNTADAEW 113 Query: 75 ALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGP--EG 132 ++ T P G Y R ++ +L Y T +H Sbjct: 114 SVYTSTFP--SGYYTNTQTYGDRV-----IPSMPRLLGKNDYKTAT---FHTNDASFYNR 163 Query: 133 AFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPP 192 P GF +F Y +++ F P Sbjct: 164 DEFYPAVGFDKF----YDRKFFGDEDVIGFSP--------------------SDEVLYNK 199 Query: 193 WLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE--------RSGR 244 P LE +Y + ++ F+ S +H P + E + Sbjct: 200 AFPILEEQY------------KNNQKFYAQLISVSSHMPFDIPKDKQEIDLPSDLKDTEL 247 Query: 245 GPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGT 304 G + +++ D +G + + D G+ ++++V+F D+ + Sbjct: 248 GNYFEAVHYADKQLGEFIQKLKDSGIWDDSVVVFYGDHHIIKTDQLPEEQKKYVNRSTQL 307 Query: 305 TYEGG--VREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLL 362 E R P +PG PG + +D++PT+ L G + + G D+ Sbjct: 308 KAEPADDYRIPFFLHYPGMENPGEIKNVGGEIDIMPTVMNLLGIKTGDQIMFGTDILN-- 365 Query: 363 LGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASS 418 P + SY + + A G+ ++ +S Sbjct: 366 SSNNYVPERYTMPEGSYFTNSYMYQPDESFETGAATNYDGTNKELSSDVKKRFDAS 421 >2W8D-A nrPDB Length = 436 Score = 75.3 bits (183), Expect = 6e-14, Method: Composition-based stats. Identities = 55/358 (15%), Positives = 110/358 (30%), Gaps = 68/358 (18%) Query: 46 TPNLDQLA--AGGLRFTDFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLE 103 TP L++LA F +F+ S A + + +YP Sbjct: 57 TPFLNKLAHDNETFYFDNFFHQTGQGKTSDAEFM-----MENSLYPLAQGSVFVNKAQNT 111 Query: 104 EVTVAEVLAARGYLTGMAGKWHLGVGP--EGAFLPPHQGFHRFLGIPYSHDQGPCQNLTC 161 +V +L ++ Y + +H + +G +F Y Sbjct: 112 LQSVPAILKSKNYTSAT---FHGNTQTFWNRNEMYKAEGIDKFFDSAY------------ 156 Query: 162 FPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFL 221 D N ++ +P F + M + +PF+ Sbjct: 157 ----------YDMNEENT---KNYGMKDKP------------FFKESMPLLESLPQPFYT 191 Query: 222 YYASHHTHYPQFSGQ---SF----AERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEET 274 + + H+P + F S + S LD ++ + GL +++ Sbjct: 192 KFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQFFNDLKKDGLYDKS 251 Query: 275 LVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG--VREPALAFWPGHIAPGVTHELAS 332 +++ D+ + ++ +L + T Y+ R P G + H+ A Sbjct: 252 IIVMYGDHYGISENHNKAMAK-VLGKDEITDYDNAQLQRVPLFIHAAG-VKGEKVHKYAG 309 Query: 333 SLDLLPTLAALAGAPLPNVTLDGFDLS--------PLLLGTGKSPRQSLFFYPSYPDE 382 +D+ PT+ L G + + G D+ P G SP+ + Y + Sbjct: 310 DVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFISPKYTKISGKYYDTK 367 >5I5H-A nrPDB Length = 586 Score = 71.5 bits (173), Expect = 8e-13, Method: Composition-based stats. Identities = 53/273 (19%), Positives = 92/273 (33%), Gaps = 37/273 (13%) Query: 141 FHRFLGIPYSHDQG------PCQNLTCFPPATPCDGGCDQGLVPIPLLAN--LSVEAQPP 192 F F GI S+ G P +T G PL LS + P Sbjct: 307 FGLFYGISPSYMDGILSTRTPAALITALNQQGYQLGLFSSDGFTSPLYRQALLSDFSMPS 366 Query: 193 WLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLM 252 + + + + ++D +F + + + T+ + Q+FA + R Sbjct: 367 VRTQSDEQTATQWINWLGRYAQEDNRWFSWVSFNGTNIDDSNQQAFARKYSRAA-----G 421 Query: 253 ELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVRE 312 +D + ++ A+ D G L+ T+VI TA G G ++ Sbjct: 422 NVDDQINRVLNALRDSGKLDNTVVIITAGRGIPLSEEEETFDWS----------HGHLQV 471 Query: 313 PALAFWPGHIAPGVTHELASSLDLLPTLAA-LAGAPLPNVTL-DGFDLSPLLLGTGKSPR 370 P + WPG A + + L DL+ TL L P G DL +P+ Sbjct: 472 PLVIHWPGTPAQRI-NALTDHTDLMTTLMQRLLHVSTPASEYSQGQDLF--------NPQ 522 Query: 371 QSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGS 403 + ++ + ++ A+ T K G Sbjct: 523 RRHYWVTAADND---TLAITTPKKTLVLNNNGK 552 >5I5F-A nrPDB Length = 586 Score = 71.5 bits (173), Expect = 8e-13, Method: Composition-based stats. Identities = 40/209 (19%), Positives = 78/209 (37%), Gaps = 24/209 (11%) Query: 141 FHRFLGIPYSHDQG------PCQNLTCFPPATPCDGGCDQGLVPIPLLAN--LSVEAQPP 192 F F GI + G P +T G PL LS + P Sbjct: 307 FGLFYGISPGYMDGVLSTRTPAALITALNQQGYQLGLFSSDGFASPLYRQALLSDFSMPA 366 Query: 193 WLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLM 252 +A+ + D + ++D +F + + + T+ + ++F +R + + Sbjct: 367 AQTQSDAQTASQWIDWLGRYAQEDNRWFSWISFNGTNIDDSNQKNFVKR-----YASAAS 421 Query: 253 ELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVRE 312 ++DA + ++ A+ + G + T+VI TA G + +G ++ Sbjct: 422 DVDAQINRVLNALREAGKFDNTVVIITAGRGIPLTPEEN----------RFDWSQGHLQV 471 Query: 313 PALAFWPGHIAPGVTHELASSLDLLPTLA 341 P + WPG A + + L D++ TL Sbjct: 472 PLVIHWPGTPAQRI-NVLTDHTDVMTTLM 499 >2W5S-A nrPDB Length = 424 Score = 70.3 bits (170), Expect = 2e-12, Method: Composition-based stats. Identities = 44/253 (17%), Positives = 81/253 (32%), Gaps = 24/253 (9%) Query: 204 FAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFA--ERSGRGP-----FGDSLMELDA 256 F D + PF+ + + HYP + A E+S G + + LD Sbjct: 174 FFKDSANYQAKMKSPFYSHLITLTNHYPFTLDEKDATIEKSNTGDATVDGYIQTARYLDE 233 Query: 257 AVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGT--TYEGGVREPA 314 A+ + + GL + ++++ D+ + + L K T + R Sbjct: 234 ALEEYINDLKKKGLYDNSVIMIYGDH--YGISENHNNAMEKLLGEKITPAKFTDLNRTGF 291 Query: 315 LAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDL--------SPLLLGTG 366 PG + G+ +E A +D++PT+ LAG N + G DL P G Sbjct: 292 WIKIPG-KSGGINNEYAGQVDVMPTILHLAGIDTKNYLMFGTDLFSKGHNQVVPFRNGDF 350 Query: 367 KSPRQSLFFYPSYPDEVRGVFAVRTGKY----KAHFFTQGSAHSDTTADPACHASSSLTA 422 + Y ++ + + + K + + D + Sbjct: 351 ITKDYKYVNGKIYSNKNNELITTQPADFEKNKKQVEKDLEMSDNVLNGDLFRFYKNPDFK 410 Query: 423 HEPPLLYDLSKDP 435 P Y P Sbjct: 411 KVNPSKYKYETGP 423 >4UOO-A nrPDB Length = 459 Score = 66.8 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 42/250 (16%), Positives = 79/250 (31%), Gaps = 25/250 (10%) Query: 168 CDGGCDQGLVPIPL-LANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQ----DRPFFLY 222 ++ + N + + Y +++ +PF+ Sbjct: 162 YKSFWNRDEIYKQFGYDNFFDASYYDMNEADVSNYGLKDKPFFKESEEYLSSLQQPFYTK 221 Query: 223 YASHHTHYPQFSGQSFA-------ERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETL 275 + + H+P + A S + + LD +V + + + GL + ++ Sbjct: 222 FITLTNHFPYPIDEKDASIAPATTGDSSVDTYFQTARYLDESVKSFVDYLKKSGLYDNSV 281 Query: 276 VIFTADNGPETMRMSRGGCSGLLRCGKGTTYE--GGVREPALAFWPGHIAPGVTHELASS 333 +I D+ + + + T+E R P + PG + GV + Sbjct: 282 IIMYGDH--YGISDNHEEAMTKILGKDYNTFENAQAQRVPLMIHVPG-VQGGVQEQYGGQ 338 Query: 334 LDLLPTLAALAGAPLPNVTLDGFDLS--------PLLLGTGKSPRQSLFFYPSYPDEVRG 385 +DLLPTL L G G DL P G +P S+ Y + Sbjct: 339 VDLLPTLLHLLGVDNKEYLQFGTDLLSKDHKQLVPFRNGDYITPTYSMIGGNMYNQQTGE 398 Query: 386 VFAVRTGKYK 395 A T + K Sbjct: 399 PIATETKEMK 408 >5KGM-A nrPDB Length = 552 Score = 54.9 bits (130), Expect = 7e-08, Method: Composition-based stats. Identities = 38/192 (19%), Positives = 62/192 (32%), Gaps = 33/192 (17%) Query: 170 GGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTH 229 G ++ LVP P +A ++ E A ++ + PF + Sbjct: 376 EGEERCLVPSPKVATYDLQP--------EMSAAGVADKMIEQLEAGTHPFIM-------- 419 Query: 230 YPQFSGQSFAERSGRGPFG-DSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNG-PETM 287 F+ +G + D A+G + A G ++ TAD+G E M Sbjct: 420 -CNFAPPDMVGHTGVYEAAVKACEATDIAIGRIYEATQKHGYS----LMVTADHGNAEKM 474 Query: 288 RMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAP 347 + GG C R P PG + D+ PT+ A+ G P Sbjct: 475 KAPDGGKHTAHTC---------YRVPLTLSHPGFKFVDPADRHPALCDVAPTVLAIMGLP 525 Query: 348 LPNVTLDGFDLS 359 P + G + Sbjct: 526 QP-AEMTGVSIV 536 >5UDY-A nrPDB Length = 422 Score = 54.9 bits (130), Expect = 8e-08, Method: Composition-based stats. Identities = 47/273 (17%), Positives = 87/273 (31%), Gaps = 51/273 (18%) Query: 23 IVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPV--SLCTPSRAALLTGR 80 ++L+ D + TPNLD +A G++ + P ++ +P L+TG+ Sbjct: 22 LLLVSFDGFRWNY-----DQDVDTPNLDAMARDGVK-ARYMTPAFVTMTSPCHFTLVTGK 75 Query: 81 LPVRMGMYPGVLV-PSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQ 139 G+ + +S+ LP G W G P ++ + Sbjct: 76 YIENHGVVHNMYYNTTSKVKLPYHATL--------GIQRW----WDNGSVP--IWITAQR 121 Query: 140 GFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEA 199 R Y G + +G AN + + A Sbjct: 122 QGLRAGSFFY--PGGNVTYQGVAVTRSRKEGIAHNYKNETEWRAN---------IDTVMA 170 Query: 200 RYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVG 259 + DL+ LY+ + ++ +S R + ++D VG Sbjct: 171 WFTEEDLDLVT----------LYFGEPDSTGHRYGPESPERRE-------MVRQVDRTVG 213 Query: 260 TLMTAIGDLGLLEETLVIFTADNGPETMRMSRG 292 L +I L + +I T+D+G T+ G Sbjct: 214 YLRESIARNHLTDRLNLIITSDHGMTTVDKRAG 246 >4LR2-A nrPDB Length = 401 Score = 51.0 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 39/284 (13%), Positives = 77/284 (27%), Gaps = 65/284 (22%) Query: 16 AVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT---DFYVPVSLCTPS 72 + + PP ++L+ D L Y P+L G+ + ++ + P+ Sbjct: 6 SSSLPPKLLLVSFDGFRADYLKNY-----EFPHLQNFIKEGVLVEHVKNVFITKTF--PN 58 Query: 73 RAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEG 132 +++TG G+ + + K H Sbjct: 59 HYSIVTGLYEESHGIVANSMYDA-------------------------VTKKH------- 86 Query: 133 AFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPP 192 S+D+ P P + + + Sbjct: 87 --------------FSDSNDKDPFWWNEAVP--IWVTNQLQENRSSAAAMWPGTDVPIHD 130 Query: 193 WLPGLEARY-----MAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPF 247 + Y + + P + A+ + P SG + + Sbjct: 131 TISSYFMNYNSSVSFEERLNNITMWLNNSNPPVTF-ATLYWEEPDASGHKY-GPEDKENM 188 Query: 248 GDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSR 291 L ++D +G L+ + LGL E VI T+D+G R Sbjct: 189 SRVLKKIDDLIGDLVQRLKMLGLWENLNVIITSDHGMTQCSQDR 232 >1O99-A nrPDB Length = 511 Score = 48.4 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 30/129 (23%), Positives = 45/129 (34%), Gaps = 20/129 (15%) Query: 232 QFSGQSFAERSGR-GPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMS 290 ++ SG+ P ++ +D +G ++ AI G + I TAD+G Sbjct: 398 NYANPDMVGHSGKLEPTIKAVEAVDECLGKVVDAILAKGG----IAIITADHG------- 446 Query: 291 RGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGVTHELASSL-DLLPTLAALAGAPLP 349 L GK T P + G+ L DL PT+ L G P P Sbjct: 447 -NADEVLTPDGKPQTAHTTNPVPVIV-----TKKGIKLRDGGILGDLAPTMLDLLGLPQP 500 Query: 350 NVTLDGFDL 358 + G L Sbjct: 501 -KEMTGKSL 508 >4B56-A nrPDB Length = 820 Score = 45.3 bits (105), Expect = 6e-05, Method: Composition-based stats. Identities = 68/415 (16%), Positives = 110/415 (26%), Gaps = 83/415 (20%) Query: 18 ARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCT-PSRAAL 76 PP ++ D L +G P + +L G + T P+ ++ Sbjct: 104 ESPPTLLFSL-DGFRAEYLHTWGGLL---PVISKLKNCGTYTKNMRPMYPTKTFPNHYSI 159 Query: 77 LTGRLPVRMGMYPGVLVP---SSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGA 133 +TG P G+ + ++ L +E W+ G Sbjct: 160 VTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPL--------------WYKGQPIWVT 205 Query: 134 FLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPW 193 + G + P G VP Sbjct: 206 ANHQEVKSGTYF------WPGSDVEIDGILPDIYKV---YNGSVPFEERI---------- 246 Query: 194 LPGLEARYMAFAHDLMADAQRQDRPFF--LYY----ASHHTHYPQFSGQSFAERSGRGPF 247 A +RP F LY +S H+H P S Sbjct: 247 ----------LAVLEWLQLPSHERPHFYTLYLEEPDSSGHSHGPVSS-----------EV 285 Query: 248 GDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYE 307 +L ++D VG LM + DLGL + +I +D+G M +G C + K Y Sbjct: 286 IKALQKVDRLVGMLMDGLKDLGLDKCLNLILISDHG-----MEQGSCKKYVYLNK---YL 337 Query: 308 GGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGT-- 365 G V + + P LA PN + L P L Sbjct: 338 GDVNNVKVVYGPAARLRPTDVPETYYSFNYEALAKNLSCREPNQHFRPY-LKPFLPKRLH 396 Query: 366 -GKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSS 419 KS R + + + A+ + K + + + A Sbjct: 397 FAKSDRIEPLTFYL---DPQWQLALNPSERKYCGSGFHGSDNLFSNMQALFIGYG 448 >5VPU-A nrPDB Length = 523 Score = 44.9 bits (104), Expect = 8e-05, Method: Composition-based stats. Identities = 41/275 (14%), Positives = 78/275 (28%), Gaps = 54/275 (19%) Query: 86 GMYPGVLVPSSRGGLPLEEVTVAEVLAAR-GYLTGMAGKWHLGVGPEGAFLPPHQGFHRF 144 + V++ + + + E L G GK L + + F Sbjct: 296 NLSKFVMLTRYQASIDAPVAYMPEELKNSLGEYLSSLGKTQLRIAETEKYAHV-----TF 350 Query: 145 LGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAF 204 D+ P G + L+P P N++ P + E Sbjct: 351 FFSGGREDEYP---------------GEKRILIPSP---NVATYDLKPEMSAYEVT---- 388 Query: 205 AHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFG-DSLMELDAAVGTLMT 263 D + A L ++ +G ++ +D +G + Sbjct: 389 --DELVKAINSGEYDLLVV--------NYANGDMVGHTGVFDAAVKAVEAVDTCLGRVYE 438 Query: 264 AIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIA 323 A+ + ++ ++ TAD+G G+ T P + P Sbjct: 439 AV----MAKKGHMLITADHGNVEQMQD-------YESGQVHTQHTTELVPFIYVGP---T 484 Query: 324 PGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDL 358 E D+ PT+ L P+P + G +L Sbjct: 485 QATIAEGGVLADVAPTILNLMQIPVP-AEMQGRNL 518 >4QAX-A nrPDB Length = 513 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 29/199 (14%), Positives = 50/199 (25%), Gaps = 28/199 (14%) Query: 164 PATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYY 223 P + L + D + + + + Sbjct: 340 PHVTYFMSGGRNEEFKGERRRLIDSPKVATYDLKPEMSAYEVKDALLEELNKGDLDLIIL 399 Query: 224 ASHHTHYPQFSGQSFAERSGR-GPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADN 282 + SG P ++ +D +G ++ I D+ + I TAD+ Sbjct: 400 NFANP--------DMVGHSGMLEPTIKAIEAVDECLGEVVDKILDM----DGYAIITADH 447 Query: 283 GPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGVTHELASSL-DLLPTLA 341 G ++ + P + GVT L DL PTL Sbjct: 448 GNSDQVLTD--DDQPMTTHTTN------PVPVIV-----TKEGVTLRETGRLGDLAPTLL 494 Query: 342 ALAGAPLPNVTLDGFDLSP 360 L P + G L Sbjct: 495 DLLNVEQPE-DMTGESLIK 512 >6A83-A nrPDB Length = 394 Score = 42.6 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 49/340 (14%), Positives = 88/340 (25%), Gaps = 52/340 (15%) Query: 19 RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGG---LRFTDFYVPVSLCTPSRAA 75 P +VL+ + G + YG+P TTP LD L F + Sbjct: 52 EPRTLVLVIGESTQRGRMSLYGYPRETTPELDALHKTDPNLTVFNNVVTSRP-------- 103 Query: 76 LLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFL 135 + + L L + ++ ++ GY T W A Sbjct: 104 -----YTIEILQQALTFANEKNPDLYLTQPSLMNMMKQAGYKTF----WITNQQTMTARN 154 Query: 136 PPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLP 195 F R Y +Q Q+ + Q ++ P L + Sbjct: 155 TMLTVFSRQTDKQYYMNQQRTQSAREYDTNV---LKPFQEVLNDPAPKKLIIVHLLGTHI 211 Query: 196 GLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELD 255 + RY + H P E + ++ + D Sbjct: 212 KYKYRYPENQGKFDGNTD---------------HVPPGLNAEELESYN--DYDNANLYND 254 Query: 256 AAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPAL 315 V +L+ +++ +D+G E G + P L Sbjct: 255 HVVASLIKDFKAANP--NGFLVYFSDHGEEVYDTPPHKTQGR---NEDNPTRHMYTIPFL 309 Query: 316 AFWPGHIAPGVTHELASSLD-------LLPTLAALAGAPL 348 + + + +D L+ T + LAG Sbjct: 310 LWTSEKWQATHPRDFSQDVDRKYSLAELIHTWSDLAGLSY 349 >5XWI-A nrPDB Length = 567 Score = 41.8 bits (96), Expect = 8e-04, Method: Composition-based stats. Identities = 19/81 (23%), Positives = 28/81 (34%), Gaps = 5/81 (6%) Query: 17 VARPPNIVL-IFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCT--PSR 73 A PP +++ I D Y T L +L + G F Y + P Sbjct: 36 AATPPKLIVAISVDQFSADLFSEY--RQYYTGGLKRLTSEGAVFPRGYQSHAATETCPGH 93 Query: 74 AALLTGRLPVRMGMYPGVLVP 94 + +LTG P R G+ Sbjct: 94 STILTGSRPSRTGIIANNWFD 114 Score = 37.2 bits (84), Expect = 0.017, Method: Composition-based stats. Identities = 18/58 (31%), Positives = 28/58 (48%), Gaps = 3/58 (5%) Query: 302 KGTTYEGGVREPALAFWPGHIAPGVTHEL-ASSLDLLPTLAALAGAPLPNVTLDGFDL 358 G+ ++ R P L + G L ++D+LP+LAAL P+P +DG L Sbjct: 491 HGSPWDTDRRVPILFWRKGM--QHFEQPLGVETVDILPSLAALIKLPVPKDQIDGRCL 546 Score = 33.3 bits (74), Expect = 0.25, Method: Composition-based stats. Identities = 9/56 (16%), Positives = 20/56 (35%), Gaps = 2/56 (3%) Query: 246 PFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCG 301 + LD +G + G+ + +V+ TAD+G + + + Sbjct: 312 ESCIQVDRLDTELGAFFDKLDKDGI--DYVVVLTADHGGHDLPERHRMNAMPMEQR 365 >6C01-A nrPDB Length = 838 Score = 40.6 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 41/264 (15%), Positives = 71/264 (26%), Gaps = 49/264 (18%) Query: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCT-PSRAALLTG 79 P ++L D L + + PN+++L G+ T P+ ++TG Sbjct: 122 PPVILFSMDGFRAEYLYTW---DTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTG 178 Query: 80 RLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQ 139 P G+ + + + + WH Sbjct: 179 LYPESHGIIDNNMYDVNLN------KNFSLSSKEQNNPAW----WH-------------- 214 Query: 140 GFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEA 199 G +L Y QG +P + G P+ + Sbjct: 215 GQPMWLTAMY---QGLKAATYFWPGSEVAING-------------SFPSIYMPYNGSVPF 258 Query: 200 RYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVG 259 D + +RP F +G + R +L +D A G Sbjct: 259 EERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSAR-----VIKALQVVDHAFG 313 Query: 260 TLMTAIGDLGLLEETLVIFTADNG 283 LM + L +I AD+G Sbjct: 314 MLMEGLKQRNLHNCVNIILLADHG 337 >5VEN-A nrPDB Length = 416 Score = 40.3 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 37/268 (13%), Positives = 71/268 (26%), Gaps = 64/268 (23%) Query: 23 IVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGL---RFTDFYVPVSLCTPSRAALLTG 79 ++++ D + L TP+ + G+ + T+ ++ + P+ L+TG Sbjct: 16 VLVVSFDGFRWDYLY-----KVPTPHFHYIMKNGVHVNQVTNVFITKTY--PNHYTLVTG 68 Query: 80 RLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGP---EGAFLP 136 G+ + E ++ K+ P Sbjct: 69 LFAENHGIVANDMFDPILNKSFSLE-----------HMDIYDSKFWEEATPIWITNQRAG 117 Query: 137 PHQGFHRFLGIPYS-HDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLP 195 G + G HD P + P D+ I Sbjct: 118 HASGAAMWPGADVKIHDSFPTY----YLPYNESVSFEDRVAKIIEWFTAKDPINLG---- 169 Query: 196 GLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELD 255 FLY+ P +G S G + ++D Sbjct: 170 ------------------------FLYW-----EEPDDTGHDVGPDSPL--MGSVISDVD 198 Query: 256 AAVGTLMTAIGDLGLLEETLVIFTADNG 283 +G L+ + L +I T+D+G Sbjct: 199 HKLGYLIKMLKRAKLWNNVNLIVTSDHG 226 >6G4G-A nrPDB Length = 840 Score = 39.5 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 39/278 (14%), Positives = 65/278 (23%), Gaps = 58/278 (20%) Query: 19 RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCT-PSRAALL 77 +PP I+ D L + S+ PN+++L GL T P+ ++ Sbjct: 115 QPPVILFSM-DGFRAEYLQTW---STLLPNINKLKTCGLHSKYMRAVYPTKTFPNHYTIV 170 Query: 78 TGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPP 137 TG P G+ + Sbjct: 171 TGLYPESHGIIDNNMYDVY----------------------------------------- 189 Query: 138 HQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPL---LANLSVEA-QPPW 193 ++ + P T G P N S + Sbjct: 190 ---LNKNFSLSSVEKSNPAWWSGQPIWLTAMYQGLKAASYYWPGSDVAVNGSFPNIYRNY 246 Query: 194 LPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLME 253 + D + +RP F + +L Sbjct: 247 SNSVPYESRIATLLQWLDLPKAERPSFYTIYVEEPDSAGHKSGPVS-----AGVIKALQL 301 Query: 254 LDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSR 291 +D A G LM + L +I AD+G + R Sbjct: 302 VDDAFGMLMEGLKQRNLHNCVNIIVLADHGMDQTSCDR 339 >5VEM-A nrPDB Length = 416 Score = 39.5 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 35/276 (12%), Positives = 72/276 (26%), Gaps = 64/276 (23%) Query: 23 IVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGL---RFTDFYVPVSLCTPSRAALLTG 79 ++L+ D + L TP+ + G+ + T+ ++ + P+ L+TG Sbjct: 16 VLLVSFDGFRWDYLY-----KVPTPHFHYIMKYGVHVKQVTNVFITKTY--PNHYTLVTG 68 Query: 80 RLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGP---EGAFLP 136 G+ + P+ + + ++ K+ P Sbjct: 69 LFAENHGIVANDMFD------PIRNKSFSL-----DHMNIYDSKFWEEATPIWITNQRAG 117 Query: 137 PHQGFHRFLGIPYS-HDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLP 195 G + G H + P T + P D+ I + Sbjct: 118 HTSGAAMWPGTDVKIHKRFP----THYMPYNESVSFEDRVAKIIEWFTSKEPIN------ 167 Query: 196 GLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELD 255 D + P G + ++D Sbjct: 168 --------LGLLYWEDPDDMGH----HLG---PDSPLM--------------GPVISDID 198 Query: 256 AAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSR 291 +G L+ + L +I T+D+G R Sbjct: 199 KKLGYLIQMLKKAKLWNTLNLIITSDHGMTQCSEER 234 >6BNF-A nrPDB Length = 344 Score = 39.1 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 48/345 (13%), Positives = 102/345 (29%), Gaps = 59/345 (17%) Query: 16 AVARPPNIVLIFA-DDLGYGDLGCYGHPSSTTPNLDQLAAGGL-----RFTDFYVPVSLC 69 A R P +V++ + G+ +T P++D+L G T + Sbjct: 25 ASTRKPRLVVMVVGETARADHASFNGYQRATFPHMDKLIGLGQVHNFGNVTSCGTSTAYS 84 Query: 70 TPSRAALL-TGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLT-GMAGKWHLG 127 P + L + V Y ++ + L+ + VA + + G+ + Sbjct: 85 VPCMFSYLGAEKYDVDTADYHENVIDT------LDRLGVAILWRDNNSDSKGVMNRLPAK 138 Query: 128 VGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSV 187 + P G + I +++ C+++ + I L Sbjct: 139 QYQDYKNSPLQGGNNT---ICHTNPYDECRDVGMLVDLDDHVKAHANQDILIVL------ 189 Query: 188 EAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE---RSGR 244 P RY + P + AE ++ Sbjct: 190 HQMGNHGPAYYKRYDDEFAQFL---------------------PVCTSSELAECERQTVI 228 Query: 245 GPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCG--K 302 + ++L+ D + + + + T +++ +D+G G G+ G K Sbjct: 229 NAYDNALLATDDFLKQTIDWLAAQTHAD-TAMLYLSDHGESL------GEKGVYLHGMPK 281 Query: 303 GTTYEGGVREPALAFWPGHIAPGVTHELASSLD---LLPTLAALA 344 + + PAL + V + + + PTL L Sbjct: 282 AFAPKEQLSIPALLWLGADTPFAVANSPTAGFSHDAITPTLLNLF 326 >2IFY-A nrPDB Length = 508 Score = 38.3 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 19/113 (16%), Positives = 38/113 (33%), Gaps = 21/113 (18%) Query: 250 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 309 ++ D +G ++ AI L ++ + + TAD+G ++ G + Sbjct: 415 AVEATDECLGKVVEAI----LAKDGVALITADHGNADEELTSEGE--PMTAHTTN----- 463 Query: 310 VREPALAF--WPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSP 360 P + G+ D+ PT+ L G P + G + Sbjct: 464 -PVPFIVTKNDVELREDGI------LGDIAPTMLTLLGVEQP-KEMTGKTIIK 508 >3IGZ-B nrPDB Length = 561 Score = 37.6 bits (85), Expect = 0.012, Method: Composition-based stats. Identities = 18/107 (16%), Positives = 30/107 (28%), Gaps = 11/107 (10%) Query: 251 LMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGV 310 + +D ++ L A+ + + I TAD+G R ++ G G Sbjct: 440 VEAVDESLAKLKDAVDSV----NGVYIVTADHGNSDDMAQRDKKGKPMKDGNGNVLPLTS 495 Query: 311 R----EPALAFWPGHIAP---GVTHELASSLDLLPTLAALAGAPLPN 350 P G A ++ T L G P Sbjct: 496 HTLSPVPVFIGGAGLDPRVAMRTDLPAAGLANVTATFINLLGFEAPE 542 >5MX9-A nrPDB Length = 324 Score = 37.6 bits (85), Expect = 0.014, Method: Composition-based stats. Identities = 14/101 (13%), Positives = 35/101 (34%), Gaps = 9/101 (8%) Query: 247 FGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTY 306 + ++L+ D + + + + +++ +D+G G +G+ G + Sbjct: 215 YDNALLATDDFIAKSIDWLKTHEANYDVAMLYVSDHGESL------GENGVYLHGMPNAF 268 Query: 307 EGGVR--EPALAFWPGHIAPGVTHELASSLD-LLPTLAALA 344 + PA + + + D + PTL L Sbjct: 269 APKEQRAVPAFFWSNNTTFKPTASDTVLTHDAITPTLLKLF 309 >5MHP-A nrPDB Length = 871 Score = 36.0 bits (81), Expect = 0.038, Method: Composition-based stats. Identities = 55/277 (19%), Positives = 79/277 (28%), Gaps = 75/277 (27%) Query: 20 PPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCT-PSRAALLT 78 P +++ D + G PN+++L + G T P+ L T Sbjct: 163 RPPLIIFSVDGFRASYMK-KGSKVM--PNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLAT 219 Query: 79 GRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPH 138 G P G+ + Y +HL + Sbjct: 220 GLYPESHGIVGNSM-----------------------YDPVFDATFHLRGREKFN----- 251 Query: 139 QGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLE 198 HR+ G G +T V IP + Q LP Sbjct: 252 ---HRWWG-------GQPLWITATKQGVKAGTFFWS--VVIPHERRILTILQWLTLPD-- 297 Query: 199 ARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLM----EL 254 +RP YA + P FSG + GPFG + E+ Sbjct: 298 ----------------HERP--SVYAFYS-EQPDFSGHKY------GPFGPEMTNPLREI 332 Query: 255 DAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSR 291 D VG LM + L L VIF D+G E + R Sbjct: 333 DKIVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDR 369 >5YLE-A nrPDB Length = 334 Score = 36.0 bits (81), Expect = 0.039, Method: Composition-based stats. Identities = 27/181 (14%), Positives = 61/181 (33%), Gaps = 26/181 (14%) Query: 184 NLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLY-YASHHTHYPQFSGQSFAE-- 240 N ++ P+ + + D +A +D L+ +H Y + + FA+ Sbjct: 137 NNAICNTNPYNECRDVGMLVGLDDFVAANNGKDMLIMLHQMGNHGPAYFKRYDEKFAKFT 196 Query: 241 -------------RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETM 287 +S + ++L+ D + + + + +++ +D+G Sbjct: 197 PVCEGNELAKCEHQSLINAYDNALLATDDFIAQSIQWLQTHSNAYDVSMLYVSDHGESL- 255 Query: 288 RMSRGGCSGLLRCGKGTTYEGGVR--EPALAFWPGH--IAPGVTHELASSLDLLPTLAAL 343 G +G+ G + + PA + I P T + + + PTL L Sbjct: 256 -----GENGVYLHGMPNAFAPKEQRSVPAFFWTDKQTGITPMATDTVLTHDAITPTLLKL 310 Query: 344 A 344 Sbjct: 311 F 311 >5OLB-A nrPDB Length = 844 Score = 36.0 bits (81), Expect = 0.043, Method: Composition-based stats. Identities = 49/273 (17%), Positives = 75/273 (27%), Gaps = 67/273 (24%) Query: 20 PPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCT-PSRAALLT 78 P +++ D + G PN+++L + G T P+ L T Sbjct: 131 RPPLIIFSVDGFRASYMK-KGSKVM--PNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLAT 187 Query: 79 GRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPH 138 G P G+ + Y +HL + Sbjct: 188 GLYPESHGIVGNSM-----------------------YDPVFDATFHLRGREKFN----- 219 Query: 139 QGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLE 198 HR+ G G +T V IP + Q LP E Sbjct: 220 ---HRWWG-------GQPLWITATKQGVRAGTFFWS--VSIPHERRILTILQWLSLPDNE 267 Query: 199 ARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAV 258 + A ++P F + P+ + L E+D V Sbjct: 268 RPSV--------YAFYSEQPDFSGHKY-GPFGPEMTNP--------------LREIDKTV 304 Query: 259 GTLMTAIGDLGLLEETLVIFTADNGPETMRMSR 291 G LM + L L VIF D+G E + R Sbjct: 305 GQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDR 337 >2W5W-A nrPDB Length = 375 Score = 35.3 bits (79), Expect = 0.071, Method: Composition-based stats. Identities = 25/144 (17%), Positives = 49/144 (34%), Gaps = 29/144 (20%) Query: 192 PWLPGLEARYMAFAHDL-MADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPF-GD 249 P + +++ A DL + + + FF+ + S + + + Sbjct: 221 PTMEKGRGNFLSAATDLAIQFLSKDNSAFFI--------MSEGSQIDWGGHANNASYLIS 272 Query: 250 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADN--GPETMRMSRGGCSGLLRCGKGTTYE 307 + + D A+GT + G TLVI T+D+ G T+ + + + + Y Sbjct: 273 EINDFDDAIGTALAFAKKDG---NTLVIVTSDHETGGFTLAAKK---NKREDGSEYSDYT 326 Query: 308 G-----------GVREPALAFWPG 320 P A+ PG Sbjct: 327 EIGPTFSTGGHSATLIPVFAYGPG 350 >3NVL-A nrPDB Length = 571 Score = 35.3 bits (79), Expect = 0.075, Method: Composition-based stats. Identities = 19/108 (17%), Positives = 33/108 (30%), Gaps = 11/108 (10%) Query: 250 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 309 SL +D ++ L A+ + + + TAD+G + R +R +G Sbjct: 458 SLEAVDQSLQRLKEAVDSV----NGVFLITADHGNSDDMVQRDKKGKPVRDAEGNLMPLT 513 Query: 310 VR----EPALAFWPGHIAP---GVTHELASSLDLLPTLAALAGAPLPN 350 P G A ++ T L G P+ Sbjct: 514 SHTLAPVPVFIGGAGLDPRVQMRTDLPRAGLANVTATFINLMGFEAPS 561 >5HI2-A nrPDB Length = 283 Score = 34.1 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 13/68 (19%), Positives = 23/68 (33%), Gaps = 4/68 (5%) Query: 80 RLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQ 139 G +P ++TV + + + + T GKWH V + Q Sbjct: 1 MHHHHHGSRDSSDDWE----IPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLTPQQLQ 56 Query: 140 GFHRFLGI 147 F +G+ Sbjct: 57 AFKNEVGV 64 >5JTL-E nrPDB Length = 471 Score = 33.7 bits (75), Expect = 0.20, Method: Composition-based stats. Identities = 28/152 (18%), Positives = 46/152 (30%), Gaps = 27/152 (17%) Query: 146 GIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLL-----ANLSVEAQPPWLPGLEAR 200 G D ++T P G G +P+ L + +++ R Sbjct: 255 GYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQR 314 Query: 201 YMAF------AHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLME- 253 + + + ++ FFL Q G S ++ + E Sbjct: 315 NDSVPTLAQMTDKAIELLSKNEKGFFL----------QVEGASIDKQDHAANPCGQIGET 364 Query: 254 --LDAAVGTLMTAIGDLGLLEETLVIFTADNG 283 LD AV + G TLVI TAD+ Sbjct: 365 VDLDEAVQRALEFAKKEG---NTLVIVTADHA 393 >5EGE-A nrPDB Length = 429 Score = 33.3 bits (74), Expect = 0.25, Method: Composition-based stats. Identities = 61/430 (14%), Positives = 113/430 (26%), Gaps = 99/430 (23%) Query: 10 ALAAGLA----VARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVP 65 L GL+ + ++++ D + ++ P ++ G++ D+ P Sbjct: 9 LLGFGLSWVWPASAHRKLLVLLLDGFRSDYISE--DALASLPGFREIVNRGVKV-DYLTP 65 Query: 66 V--SLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPL----EEVTVAEVLAARGYLTG 119 SL P+ L+TGR M + + + Sbjct: 66 DFPSLSYPNYYTLMTGRHCEVHQMIGNYMWDPRTNKSFDIGVNRDSLMPL---------- 115 Query: 120 MAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSH------DQGPCQNLTCFPPATPCDGGCD 173 W G P L + P C P Sbjct: 116 ----WWNGSEPLWITLMKARRKVYMYYWPGCEVEILGVRPTYCLEYKTVPTDINFANAVS 171 Query: 174 QGLVPIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQF 233 L L A A H+ + HY Sbjct: 172 DAL---------------DSLKSGRADLAAIYHERIDVEGH--------------HYGPS 202 Query: 234 SGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGG 293 S Q D+L +D + ++ I D GL ++ VI +D+G + Sbjct: 203 SPQR----------KDALRAVDTVLKYMIQWIQDRGLQQDLNVILFSDHGMTDIFWMDKV 252 Query: 294 CSGLLRCGKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNV-- 351 + R P ++ WP PG E+ L + + +PN Sbjct: 253 IELSNYISLDDLQQVKDRGPVVSLWP---VPGKHSEIYHKLRTVEHMTVYEKESIPNRFY 309 Query: 352 -------------------TLDGFDLSPLL---LGTGKSPRQSLFFYPSYPDEVRGVFAV 389 + ++ P G + ++ Y + ++RG+F Sbjct: 310 YKKGKFVSPLTLVADEGWFIAESREMLPFWMNSTGKREGWQRGWHGYDNELMDMRGIFLA 369 Query: 390 RTGKYKAHFF 399 +K++F Sbjct: 370 IGPDFKSNFR 379 >2W9X-A nrPDB Length = 366 Score = 32.9 bits (73), Expect = 0.31, Method: Composition-based stats. Identities = 39/266 (14%), Positives = 63/266 (23%), Gaps = 44/266 (16%) Query: 40 GHPSSTTPNLDQLAAGGLRFTDFYV---PVSLCTPSRAALLTGRLPVRMGMYPGVLVPSS 96 G L + + RF FY L P R ++ Sbjct: 105 GKHRVRLEKLTETQSTSGRFLGFYTDPSAKPLALPKR--------KRQIEFIGDSFTVGY 156 Query: 97 RGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPC 156 P E T E+ GP + F I S G Sbjct: 157 GNTSPSRECTDEELFKTTNSQMAF--------GPL-----TAKAFDADYQINASSGFGIV 203 Query: 157 QNLTCFPPATPCDGGCDQGLV-PIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQ 215 +N P L P L N + Q + + + D +R Sbjct: 204 RNYNGTSPDKSLLSLYPYTLNNPDQLYHNKHWKPQVIVIGLGTNDFSTA----LNDNERW 259 Query: 216 DRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLM-----ELDAAVGTLMTAIGDLGL 270 L+ + + + R F E+ VG ++ + GL Sbjct: 260 KTREALHADYVANYVKFV--KQLHSNNARAQFILMNSDQSNGEIAEQVGKVVAQLKGGGL 317 Query: 271 LEETLVIFTADNGPETMRMSRGGCSG 296 + ++F + GC Sbjct: 318 HQVEQIVF--------KGLDYSGCHW 335 >2MLZ-B nrPDB Length = 114 Score = 31.4 bits (69), Expect = 0.95, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 16/35 (45%), Gaps = 3/35 (8%) Query: 249 DSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNG 283 ++LD AV + G TLVI TAD+ Sbjct: 5 GETVDLDEAVQRALEFAKKEG---NTLVIVTADHA 36 >4BLN-A nrPDB Length = 332 Score = 30.2 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 12/38 (31%), Positives = 16/38 (42%) Query: 308 GGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAG 345 GGVR P P +A H + D + T+ A G Sbjct: 117 GGVRIPFFLGRPDAVAASPDHLVPEPFDSVDTILARMG 154 >6FXY-A nrPDB Length = 718 Score = 29.5 bits (64), Expect = 3.9, Method: Composition-based stats. Identities = 18/135 (13%), Positives = 36/135 (26%), Gaps = 3/135 (2%) Query: 127 GVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLS 186 P+ AF + FL + H+ G + + P+ Sbjct: 463 DTDPDMAFCKSFRDKGIFLHLSNQHEFGRLLATSRYDTEHLHPDLWQIFDNPVDWKEQYI 522 Query: 187 VEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGP 246 E L G + + HY Q+SG + G Sbjct: 523 HENYSRALEGEGIVEQPCPDVYWFPLLSEQ--MCDELVAEMEHYGQWSGGRHEDSRLAGG 580 Query: 247 FGDSLMELDAAVGTL 261 + +++ +D + + Sbjct: 581 Y-ENVPTVDIHMKQV 594 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.303 0.115 0.299 Lambda K H 0.267 0.0355 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,564,774 Number of Sequences: 36641 Number of extensions: 679982 Number of successful extensions: 2011 Number of sequences better than 10.0: 55 Number of HSP's better than 10.0 without gapping: 61 Number of HSP's successfully gapped in prelim test: 34 Number of HSP's that attempted gapping in prelim test: 1725 Number of HSP's gapped (non-prelim): 143 length of query: 507 length of database: 10,336,785 effective HSP length: 101 effective length of query: 406 effective length of database: 6,636,044 effective search space: 2694233864 effective search space used: 2694233864 T: 11 A: 40 X1: 16 ( 7.0 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.0 bits) S2: 61 (28.3 bits)