BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P15169 (458 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2NSM-A nrPDB 912 0.0 1QMU-A nrPDB 380 e-106 1UWY-A nrPDB 298 3e-81 3MN8-A nrPDB 286 1e-77 3V7Z-A nrPDB 84 1e-16 5AQ0-A nrPDB 69 3e-12 2BOA-A nrPDB 56 3e-08 4BD9-A nrPDB 56 4e-08 1AYE-A nrPDB 48 8e-06 1DTD-A nrPDB 46 3e-05 1JQG-A nrPDB 45 9e-05 4A39-A nrPDB 42 6e-04 3KGQ-A nrPDB 42 6e-04 5HXD-A nrPDB 42 7e-04 3LMS-A nrPDB 36 0.039 4B6Z-A nrPDB 36 0.040 3D68-A nrPDB 35 0.051 1KWM-A nrPDB 35 0.069 1PCA-A nrPDB 35 0.083 4AXV-A nrPDB 35 0.092 4OKO-A nrPDB 35 0.099 1ZLI-A nrPDB 34 0.13 3K2K-A nrPDB 33 0.21 3L2N-A nrPDB 33 0.27 3D4U-A nrPDB 33 0.34 4UEE-A nrPDB 32 0.40 3OSL-A nrPDB 32 0.48 1J3B-A nrPDB 32 0.49 5OM9-A nrPDB 32 0.60 5MRV-A nrPDB 32 0.74 3FMC-A nrPDB 29 4.6 1TSF-A nrPDB 28 7.3 2C1C-A nrPDB 28 9.9 >2NSM-A nrPDB Length = 439 Score = 912 bits (2358), Expect = 0.0, Method: Compositional matrix adjust. Identities = 434/438 (99%), Positives = 437/438 (99%) Query: 21 VTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVK 80 + FRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVK Sbjct: 2 LAFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVK 61 Query: 81 YVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQ 140 YVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQ Sbjct: 62 YVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQ 121 Query: 141 GPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRAV 200 GPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRAV Sbjct: 122 GPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRAV 181 Query: 201 IRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVYSY 260 IRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVYSY Sbjct: 182 IRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVYSY 241 Query: 261 AHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKFPPEEEL 320 AHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKFPPEEEL Sbjct: 242 AHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKFPPEEEL 301 Query: 321 QREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAVISVSGINHDVTSGDHGDYFRLL 380 QREWLGN+EALIQFLEQVHQGIKGMVLD+NYNNLANAVISVSGINHDVTSGDHGDYFRLL Sbjct: 302 QREWLGNKEALIQFLEQVHQGIKGMVLDQNYNNLANAVISVSGINHDVTSGDHGDYFRLL 361 Query: 381 LPGIYTVSATAPGYDPETVTVTVGPAEPTLVNFHLKRSIPQVSPVRRAPSRRHGVRAKVQ 440 LPGIYTVSATAPGYDPETVTVTVGPAEPTLVNFHLKRSIPQVSPVRRAPSRRHGVRAKVQ Sbjct: 362 LPGIYTVSATAPGYDPETVTVTVGPAEPTLVNFHLKRSIPQVSPVRRAPSRRHGVRAKVQ 421 Query: 441 PQARKKEMEMRQLQRGPA 458 PQARKKEMEMRQLQRGPA Sbjct: 422 PQARKKEMEMRQLQRGPA 439 >1QMU-A nrPDB Length = 380 Score = 380 bits (975), Expect = e-106, Method: Compositional matrix adjust. Identities = 205/409 (50%), Positives = 266/409 (65%), Gaps = 35/409 (8%) Query: 16 KLVAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPL 75 + V PV FRHH + D+ L + NE P ITR+YS+G+SVE R LYV+E SD+PGIHE Sbjct: 1 QAVQPVDFRHHHFSDMEIFLRRYANEYPSITRLYSVGKSVELRELYVMEISDNPGIHEAG 60 Query: 76 EPEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYE 135 EPE KY+GNMHGNE +GREL+L L E+LC+ F + + L+Q TRIHI+PSMNPDGYE Sbjct: 61 EPEFKYIGNMHGNEVVGRELLLNLIEYLCKNF-GTDPEVTDLVQSTRIHIMPSMNPDGYE 119 Query: 136 VAAAQGPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEP 195 +Q ++ G VGRNN+N DLNRNFPD + D +P Sbjct: 120 --KSQEGDRGG-TVGRNNSNNYDLNRNFPD---------------QFFQVTD----PPQP 157 Query: 196 ETRAVIRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLA 255 ET AV+ W+ ++ FVLSANLHGG++V NYP+D +G+ + +PDD +FQ+LA Sbjct: 158 ETLAVMSWLKTYPFVLSANLHGGSLVVNYPFDDD----EQGI--AIYSKSPDDAVFQQLA 211 Query: 256 KVYSYAHGWMFQGWNCGD-----YFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELS 310 YS + M+QG C D YFP GITNGA WY++ GMQD+NYL+TNCFE+T+EL Sbjct: 212 LSYSKENKKMYQGSPCKDLYPTEYFPHGITNGAQWYNVPGGMQDWNYLNTNCFEVTIELG 271 Query: 311 CDKFPPEEELQREWLGNREALIQFLEQVHQGIKGMVLDE-NYNNLANAVISVSGINHDVT 369 C K+P EEL + W NR +L+QF++QVH+GI G VLD + + NA ISV+ INH VT Sbjct: 272 CVKYPKAEELPKYWEQNRRSLLQFIKQVHRGIWGFVLDATDGRGILNATISVADINHPVT 331 Query: 370 SGDHGDYFRLLLPGIYTVSATAPGYDPETVTVTVGPAEPTLVNFHLKRS 418 + GDY+RLL+ G Y V+A+A GYDP T TV V VNF L R+ Sbjct: 332 TYKDGDYWRLLVQGTYKVTASARGYDPVTKTVEVDSKGGVQVNFTLSRT 380 >1UWY-A nrPDB Length = 426 Score = 298 bits (764), Expect = 3e-81, Method: Compositional matrix adjust. Identities = 169/391 (43%), Positives = 232/391 (59%), Gaps = 38/391 (9%) Query: 21 VTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVK 80 + F +HR + + L V +T ++SIG+SV+GR+L+VL P H PE K Sbjct: 1 LDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVLVVGRFPKEHRIGIPEFK 60 Query: 81 YVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQ 140 YV NMHG+E +GREL+L L ++L ++ I LI TRIHI+PSMNPDG+E A + Sbjct: 61 YVANMHGDETVGRELLLHLIDYLVTS-DGKDPEITNLINSTRIHIMPSMNPDGFE--AVK 117 Query: 141 GPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRAV 200 P+ Y +GR N N DLNRNFPD Y +N Q PET AV Sbjct: 118 KPDC-YYSIGRENYNQYDLNRNFPDAFEY-----------------NNVSRQ--PETVAV 157 Query: 201 IRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTAS----TPTPDDKLFQKLAK 256 ++W+ + FVLSANLHGGA+VA+YP+D GV+ T + + TPDD +FQ LA Sbjct: 158 MKWLKTETFVLSANLHGGALVASYPFD-------NGVQATGALYSRSLTPDDDVFQYLAH 210 Query: 257 VYSYAHGWMFQGWNCGDY--FPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKF 314 Y+ + M +G C + FP+G+TNG SWY L GMQD+NY+ CFEITLELSC K+ Sbjct: 211 TYASRNPNMKKGDECKNKMNFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKY 270 Query: 315 PPEEELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAVISVSGINHDV--TSGD 372 P EE+L W N+ +LI++++QVH G+KG V D+N N L N ++ V H + Sbjct: 271 PREEKLPSFWNNNKASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNK 330 Query: 373 HGDYFRLLLPGIYTVSATAPGYDPETVTVTV 403 +G+Y+ LLLPG Y ++ T PG+DP V + Sbjct: 331 YGEYYLLLLPGSYIINVTVPGHDPHITKVII 361 >3MN8-A nrPDB Length = 435 Score = 286 bits (732), Expect = 1e-77, Method: Compositional matrix adjust. Identities = 166/404 (41%), Positives = 234/404 (57%), Gaps = 27/404 (6%) Query: 17 LVAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLE 76 L P + +DL L K P +V+ +GRS+EGR+L L+ S + L Sbjct: 35 LQQPHYASQEQLEDLFAGLEKAY---PNQAKVHFLGRSLEGRNLLALQISRNTRSRNLLT 91 Query: 77 PEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEV 136 P VKY+ NMHG+E +GR+L++ ++++L R + QL+ T I+++P+MNPDGY + Sbjct: 92 PPVKYIANMHGDETVGRQLLVYMAQYLLGN-HERISDLGQLVNSTDIYLVPTMNPDGYAL 150 Query: 137 AAAQGPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQV-EP 195 + VGR NA +DLNR+FPD + H L ++Q +P Sbjct: 151 SQEGNCESLPNYVGRGNAANIDLNRDFPDRLEQSHV--------HQL------RAQSRQP 196 Query: 196 ETRAVIRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLA 255 ET A++ W+ S FVLSAN HGGAVVA+YPYD S H + TPDD++F++LA Sbjct: 197 ETAALVNWIVSKPFVLSANFHGGAVVASYPYDNSLAHN----ECCEESLTPDDRVFKQLA 252 Query: 256 KVYSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKFP 315 YS H M +G NC D F GITNGA WY LS GMQDFNY +NCFE+T+ELSC K+P Sbjct: 253 HTYSDNHPIMRKGNNCNDSFSGGITNGAHWYELSGGMQDFNYAFSNCFELTIELSCCKYP 312 Query: 316 PEEELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAVISVSGINHD-VTSGDHG 374 L +EW N+ +L+Q L Q H GIKG+V D + +A+A + V+G+ + + G Sbjct: 313 AASTLPQEWQRNKASLLQLLRQAHIGIKGLVTDASGFPIADANVYVAGLEEKPMRTSKRG 372 Query: 375 DYFRLLLPGIYTVSATAPGYD---PETVTVTVGPAEPTLVNFHL 415 +Y+RLL PG+Y+V A+A GY P+ V VT E ++F L Sbjct: 373 EYWRLLTPGLYSVHASAFGYQTSAPQQVRVTNDNQEALRLDFKL 416 >3V7Z-A nrPDB Length = 326 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 85/330 (25%), Positives = 141/330 (42%), Gaps = 42/330 (12%) Query: 25 HHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGN 84 +H Y+++V + V + P I + +SIG+S EGR L+ ++ SD+ G E EPEV Y Sbjct: 9 YHNYNEMVNKINTVASNYPNIVKKFSIGKSYEGRELWAVKISDNVGTDEN-EPEVLYTAL 67 Query: 85 MHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGPNK 144 H E L E+ L + + + N + RI L+ + I+I+ ++NPDG E + G K Sbjct: 68 HHAREHLTVEMALYTLDLFTQNY-NLDSRITNLVNNREIYIVFNINPDGGEYDISSGSYK 126 Query: 145 PGYLVGRNNAN----GVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRAV 200 + N+ G DLNRN+ Y + + + PET A+ Sbjct: 127 SWRKNRQPNSGSSYVGTDLNRNYG----YKWGCCGGSSGSPSSETYRGRSAFSAPETAAM 182 Query: 201 IRWMHSF------NFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDD-KLFQK 253 +++S H + + YPY ++ S T DD +F+ Sbjct: 183 RDFINSRVVGGKQQIKTLITFHTYSELILYPYGYTYTD-------VPSDMTQDDFNVFKT 235 Query: 254 LAKVYSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDK 313 +A + +G+ Q D + IT+G M D+ Y F T E+ Sbjct: 236 MANTMAQTNGYTPQ--QASDLY---ITDG--------DMTDWAYGQHKIFAFTFEMYPTS 282 Query: 314 -----FPPEEELQREWLGNREALIQFLEQV 338 +PP+E + RE N+EA++ E+ Sbjct: 283 YNPGFYPPDEVIGRETSRNKEAVLYVAEKA 312 >5AQ0-A nrPDB Length = 82 Score = 69.3 bits (168), Expect = 3e-12, Method: Composition-based stats. Identities = 39/80 (48%), Positives = 52/80 (65%), Gaps = 6/80 (7%) Query: 341 GIKGMVLDE-NYNNLANAVISVSGINHDVTSGDHGDYFRLLLPGIYTVSATAPGYDPETV 399 G+KG V D + L NA ISV+GINH++T+G GD++RLL+PG Y ++ GY P TV Sbjct: 2 GVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFYRLLVPGTYNLTVVLTGYMPLTV 61 Query: 400 TVTV---GPAEPTLVNFHLK 416 T V GPA T V+F L+ Sbjct: 62 TNVVVKEGPA--TEVDFSLR 79 >2BOA-A nrPDB Length = 404 Score = 55.8 bits (133), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 63/269 (23%), Positives = 106/269 (39%), Gaps = 47/269 (17%) Query: 25 HHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGN 84 +H + + + + + P + R IG S E R +YVL+FS G+ P V Sbjct: 106 YHSLEAIYHEMDNIAADFPDLARRVKIGHSFENRPMYVLKFSTGKGVR---RPAVWLNAG 162 Query: 85 MHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQG--- 141 +H E + + + + + +++ R+ I +++ I +LP NPDGY Q Sbjct: 163 IHSREWISQATAIWTARKIVSDYQ-RDPAITSILEKMDIFLLPVANPDGYVYTQTQNRLW 221 Query: 142 ----PNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQV---- 193 PG ++ G D NRN +N + G DN S+V Sbjct: 222 RKTRSRNPG-----SSCIGADPNRN---------WNASFAGKG----ASDNPCSEVYHGP 263 Query: 194 ----EPETRAVIRWMHSF-NFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDD 248 E E ++V+ ++ NF +LH + + YPY S + A D Sbjct: 264 HANSEVEVKSVVDFIQKHGNFKGFIDLHSYSQLLMYPYGYSV--------KKAPDAEELD 315 Query: 249 KLFQKLAKVYSYAHGWMFQ-GWNCGDYFP 276 K+ + AK + G +Q G C +P Sbjct: 316 KVARLAAKALASVSGTEYQVGPTCTTVYP 344 >4BD9-A nrPDB Length = 310 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 63/269 (23%), Positives = 106/269 (39%), Gaps = 47/269 (17%) Query: 25 HHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGN 84 +H + + + + + P + R IG S E R +YVL+FS G+ P V Sbjct: 12 YHSLEAIYHEMDNIAADFPDLARRVKIGHSFENRPMYVLKFSTGKGVR---RPAVWLNAG 68 Query: 85 MHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQG--- 141 +H E + + + + + +++ R+ I +++ I +LP NPDGY Q Sbjct: 69 IHSREWISQATAIWTARKIVSDYQ-RDPAITSILEKMDIFLLPVANPDGYVYTQTQNRLW 127 Query: 142 ----PNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQV---- 193 PG ++ G D NRN +N + G DN S+V Sbjct: 128 RKTRSRNPG-----SSCIGADPNRN---------WNASFAGKG----ASDNPCSEVYHGP 169 Query: 194 ----EPETRAVIRWMHSF-NFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDD 248 E E ++V+ ++ NF +LH + + YPY S + A D Sbjct: 170 HANSEVEVKSVVDFIQKHGNFKGFIDLHSYSQLLMYPYGYSV--------KKAPDAEELD 221 Query: 249 KLFQKLAKVYSYAHGWMFQ-GWNCGDYFP 276 K+ + AK + G +Q G C +P Sbjct: 222 KVARLAAKALASVSGTEYQVGPTCTTVYP 250 >1AYE-A nrPDB Length = 401 Score = 48.1 bits (113), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 47/209 (22%), Positives = 91/209 (43%), Gaps = 22/209 (10%) Query: 25 HHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGN 84 +H +++ + + + E PG+ +IG S E R + VL+FS +P + Sbjct: 105 YHTLEEISQEMDNLVAEHPGLVSKVNIGSSFENRPMNVLKFSTGGD-----KPAIWLDAG 159 Query: 85 MHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGP-- 142 +H E + + L + + ++ ++ I ++ I +LP NPDGY + + Sbjct: 160 IHAREWVTQATALWTANKIVSDY-GKDPSITSILDALDIFLLPVTNPDGYVFSQTKNRMW 218 Query: 143 NKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHL-PLPDNW---KSQVEPETR 198 K V + GVD NRN ++ +GGP P D++ + E E + Sbjct: 219 RKTRSKVSGSLCVGVDPNRN---------WDAGFGGPGASSNPCSDSYHGPSANSEVEVK 269 Query: 199 AVIRWMHSFNFVLS-ANLHGGAVVANYPY 226 +++ ++ S V + LH + + +PY Sbjct: 270 SIVDFIKSHGKVKAFIILHSYSQLLMFPY 298 >1DTD-A nrPDB Length = 303 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 45/210 (21%), Positives = 90/210 (42%), Gaps = 23/210 (10%) Query: 25 HHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGN 84 +H +++ + + + E PG+ +IG S E R + VL+FS +P + Sbjct: 6 YHTLEEISQEMDNLVAEHPGLVSKVNIGSSFENRPMNVLKFSTGGD-----KPAIWLDAG 60 Query: 85 MHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQG--- 141 +H E + + L + + ++ ++ I ++ I +LP NPDGY + + Sbjct: 61 IHAREWVTQATALWTANKIVSDY-GKDPSITSILDALDIFLLPVTNPDGYVFSQTKNRMW 119 Query: 142 PNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHL-PLPDNW---KSQVEPET 197 + + GVD NRN ++ +GGP P D++ + E E Sbjct: 120 RKTRSKVSAGSLCVGVDPNRN---------WDAGFGGPGASSNPCSDSYHGPSANSEVEV 170 Query: 198 RAVIRWMHSFNFVLS-ANLHGGAVVANYPY 226 ++++ ++ S V + LH + + +PY Sbjct: 171 KSIVDFIKSHGKVKAFIILHSYSQLLMFPY 200 >1JQG-A nrPDB Length = 433 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 43/144 (29%), Positives = 59/144 (40%), Gaps = 14/144 (9%) Query: 26 HRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGNM 85 H Y+++ L ++ E P + V G+S EGR + L S + +P V + Sbjct: 122 HSYEEVDAYLQELAKEFPNVVTVVEGGKSFEGRSIKYLRIST-TNFQDASKPVVMMQSLL 180 Query: 86 HGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGP--- 142 H E + L L + + LI + ILP NPDGY V G Sbjct: 181 HCREWVTLPATLYAIHKLVIDVTESD-----LINNIDWIILPVANPDGY-VHTFGGDRYW 234 Query: 143 ---NKPGYLVGRNNANGVDLNRNF 163 GY+ G N GVDLNRNF Sbjct: 235 RKNRATGYMAG-NLCMGVDLNRNF 257 >4A39-A nrPDB Length = 388 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 36/120 (30%), Positives = 56/120 (46%), Gaps = 19/120 (15%) Query: 44 GITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGNMHGNEALGRELMLQLSEFL 103 G+ R+ ++G SV+GR + +L HP H L + H E + M L E L Sbjct: 143 GVERL-AVGTSVQGRDIELLRVRRHPDSHLKL----WVIAQQHPGEHMAEWFMEGLIERL 197 Query: 104 CEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLNRNF 163 R + + +L++ ++++P+MNPDG A G R NA G DLNR + Sbjct: 198 Q---RPDDTEMQRLLEKADLYLVPNMNPDG----AFHGNL-------RTNAAGQDLNRAW 243 >3KGQ-A nrPDB Length = 309 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 35/145 (24%), Positives = 62/145 (42%), Gaps = 15/145 (10%) Query: 25 HHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEF----SDHPGIHEPLEPEVK 80 +H D++ + + E P + IGRS EGR +YVL+F S+ P I L Sbjct: 12 YHTLDEIYDFMDLLVAEHPQLVSKLQIGRSYEGRPIYVLKFSTGGSNRPAIWIDL----- 66 Query: 81 YVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQ 140 +H E + + + ++ E++ ++ ++ I + NPDG+ +Q Sbjct: 67 ---GIHSREWITQATGVWFAKKFTEDY-GQDPSFTAILDSMDIFLEIVTNPDGFAFTHSQ 122 Query: 141 GP--NKPGYLVGRNNANGVDLNRNF 163 K + + GVD NRN+ Sbjct: 123 NRLWRKTRSVTSSSLCVGVDANRNW 147 >5HXD-A nrPDB Length = 237 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 30/98 (30%), Positives = 41/98 (41%), Gaps = 15/98 (15%) Query: 122 RIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLNRNFPDLN---TYIYYNEKYGG 178 R H++ +NPDG ++ R NANGVDLNRNFP N Y Sbjct: 72 RHHVVLCVNPDGCQLGL------------RANANGVDLNRNFPAANWKEGETVYRWNSAA 119 Query: 179 PNHHLPLPDNWKSQVEPETRAVIRWMHSFNFVLSANLH 216 + L K EPET+A+ + +H + H Sbjct: 120 EERDVVLLTGDKPGSEPETQALCQLIHRIQPAWVVSFH 157 >3LMS-A nrPDB Length = 309 Score = 35.8 bits (81), Expect = 0.039, Method: Compositional matrix adjust. Identities = 51/248 (20%), Positives = 96/248 (38%), Gaps = 21/248 (8%) Query: 24 RHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVG 83 ++H +++ + + P + IG S E LYVL+ S G + + + Sbjct: 8 QYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVS---GKEQAAKNAIWIDC 64 Query: 84 NMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQG-- 141 +H E + L + +F + L++ +++P +N DGY+ + + Sbjct: 65 GIHAREWISPAFCLWFIGHI-TQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRM 123 Query: 142 --PNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRA 199 N+ Y N+ G DLNRNF ++ E+ + + EPE +A Sbjct: 124 WRKNRSFY--ANNHCIGTDLNRNFASK----HWCEEGASSSSCSETYCGLYPESEPEVKA 177 Query: 200 VI----RWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLA 255 V R ++ +S + + +V Y Y +S + AS + +K + Sbjct: 178 VASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAV---RAIEKTS 234 Query: 256 KVYSYAHG 263 K Y HG Sbjct: 235 KNTRYTHG 242 >4B6Z-A nrPDB Length = 405 Score = 35.8 bits (81), Expect = 0.040, Method: Compositional matrix adjust. Identities = 32/117 (27%), Positives = 51/117 (43%), Gaps = 13/117 (11%) Query: 48 VYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGNMHGNEALGRELMLQLSEFLCEEF 107 V +GR+VEGR + +L P + +V + H E++ + L + L Sbjct: 155 VVELGRTVEGRPMSLLTLGT-PETDGAPKKKVWIIARQHPGESMAEWFVEGLVKRLAGWG 213 Query: 108 RNRNQRIVQLIQD-TRIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLNRNF 163 + + + D HI+P+MNPDG + G L R NA G +LNR + Sbjct: 214 DWAGDPVARKLYDRVTFHIVPNMNPDG---------SVHGNL--RTNAAGANLNREW 259 >3D68-A nrPDB Length = 424 Score = 35.4 bits (80), Expect = 0.051, Method: Compositional matrix adjust. Identities = 50/248 (20%), Positives = 97/248 (39%), Gaps = 21/248 (8%) Query: 24 RHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVG 83 ++H +++ + + P + IG S E LYVL+ S G + + + Sbjct: 123 QYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVS---GKEQTAKNAIWIDC 179 Query: 84 NMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQG-- 141 +H E + L + +F + L++ +++P +N DGY+ + + Sbjct: 180 GIHAREWISPAFCLWFIGHI-TQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRM 238 Query: 142 --PNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRA 199 N+ Y N+ G DLNRNF ++ E+ + + EPE +A Sbjct: 239 WRKNRSFY--ANNHCIGTDLNRNFASK----HWCEEGASSSSCSETYCGLYPESEPEVKA 292 Query: 200 VI----RWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLA 255 V R ++ +S + + +V Y Y +S + AS + +K++ Sbjct: 293 VASFLRRNINQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAV---RAIEKIS 349 Query: 256 KVYSYAHG 263 K Y +G Sbjct: 350 KNIRYTYG 357 >1KWM-A nrPDB Length = 402 Score = 35.0 bits (79), Expect = 0.069, Method: Compositional matrix adjust. Identities = 46/219 (21%), Positives = 88/219 (40%), Gaps = 28/219 (12%) Query: 24 RHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVG 83 ++++++ + +V E P + IG + EGR +Y+L+ G +P + Sbjct: 103 KYNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKV----GKAGQNKPAIFMDC 158 Query: 84 NMHGNEALGRELMLQLSEFLCEEFRN--RNQRIVQLIQDTRIHILPSMNPDGYEVAAAQG 141 H E + F+ E R R ++ +L+ ++LP +N DGY + Sbjct: 159 GFHAREWISPAF---CQWFVREAVRTYGREIQVTELLNKLDFYVLPVLNIDGYIYTWTKS 215 Query: 142 P--NKPGYLVGRNNANGVDLNRNFPDLNTYIY-----YNEKYGGPNHHLPLPDNWKSQVE 194 K ++ G D NRNF I +E Y GP ++ E Sbjct: 216 RFWRKTRSTHTGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGP----------AAESE 265 Query: 195 PETRAVIRWMHSFNFVLSA--NLHGGAVVANYPYDKSFE 231 ET+A+ ++ + + A +H + + YPY +++ Sbjct: 266 KETKALADFIRNKLSSIKAYLTIHSYSQMMIYPYSYAYK 304 >1PCA-A nrPDB Length = 403 Score = 34.7 bits (78), Expect = 0.083, Method: Compositional matrix adjust. Identities = 24/110 (21%), Positives = 48/110 (43%), Gaps = 5/110 (4%) Query: 25 HHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGN 84 +H +++ + + E P + IGRS EGR +YVL+FS P + Sbjct: 107 YHTLEEIYDFMDILVAEHPALVSKLQIGRSYEGRPIYVLKFSTGGSNR----PAIWIDSG 162 Query: 85 MHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGY 134 +H E + + + ++ + E + +N ++ I + NP+G+ Sbjct: 163 IHSREWITQASGVWFAKKITENY-GQNSSFTAILDSMDIFLEIVTNPNGF 211 >4AXV-A nrPDB Length = 243 Score = 34.7 bits (78), Expect = 0.092, Method: Compositional matrix adjust. Identities = 26/80 (32%), Positives = 34/80 (42%), Gaps = 15/80 (18%) Query: 125 ILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLNRNFPDLNTY---IYYNEKYGGPNH 181 ++ SMNPD ++ R NAN VDLNR FP N Y P Sbjct: 81 VILSMNPDANQLGT------------RANANQVDLNRAFPTQNWTEHGTVYRWSSHTPVR 128 Query: 182 HLPLPDNWKSQVEPETRAVI 201 + + K Q+EPE A+I Sbjct: 129 DVKVKTGDKEQLEPEVDALI 148 >4OKO-A nrPDB Length = 312 Score = 34.7 bits (78), Expect = 0.099, Method: Compositional matrix adjust. Identities = 24/88 (27%), Positives = 38/88 (43%), Gaps = 22/88 (25%) Query: 76 EPEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYE 135 +P V G +HG E G + + ++ R ++ +D I ILP ++P GYE Sbjct: 76 KPYVLVTGGVHGYETSGVQGAISFAQ----------TRALEFARDYNIVILPCLSPWGYE 125 Query: 136 VAAAQGPNKPGYLVGRNNANGVDLNRNF 163 + R N N +D NR+F Sbjct: 126 T------------INRWNPNALDPNRSF 141 >1ZLI-A nrPDB Length = 309 Score = 34.3 bits (77), Expect = 0.13, Method: Compositional matrix adjust. Identities = 46/219 (21%), Positives = 87/219 (39%), Gaps = 28/219 (12%) Query: 24 RHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVG 83 +++ ++ + +V E P + IG + EGR +Y+L+ G +P + Sbjct: 10 KYNNWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKV----GKAGQNKPAIFMDC 65 Query: 84 NMHGNEALGRELMLQLSEFLCEEFRN--RNQRIVQLIQDTRIHILPSMNPDGYEVAAAQG 141 H E + F+ E R R ++ +L+ ++LP +N DGY + Sbjct: 66 GFHAREWISPAF---CQWFVREAVRTYGREIQVTELLNKLDFYVLPVLNIDGYIYTWTKS 122 Query: 142 P--NKPGYLVGRNNANGVDLNRNFPDLNTYIY-----YNEKYGGPNHHLPLPDNWKSQVE 194 K ++ G D NRNF I +E Y GP ++ E Sbjct: 123 RFWRKTRSTHTGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGP----------AAESE 172 Query: 195 PETRAVIRWMHSFNFVLSA--NLHGGAVVANYPYDKSFE 231 ET+A+ ++ + + A +H + + YPY +++ Sbjct: 173 KETKALADFIRNKLSSIKAYLTIHSYSQMMIYPYSYAYK 211 >3K2K-A nrPDB Length = 403 Score = 33.5 bits (75), Expect = 0.21, Method: Compositional matrix adjust. Identities = 34/119 (28%), Positives = 52/119 (43%), Gaps = 17/119 (14%) Query: 48 VYSIGRSVEGR--HLYVLEFSDHPGIHEPLEPEVKYVGNMHGNEALGRELMLQLSEFLCE 105 V +GR+VEGR L VL D G + +V + H E++ + L + L Sbjct: 153 VVELGRTVEGRPMSLVVLGTPDEAG---AAKKKVWIIARQHPGESMAEWFIEGLVKRLVG 209 Query: 106 EFRNRNQRIVQLIQD-TRIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLNRNF 163 + + + D +I+P+MNPDG + G L R NA G +LNR + Sbjct: 210 WGDWSGDPVARKLYDHATFYIVPNMNPDG---------SVHGNL--RTNAAGANLNREW 257 >3L2N-A nrPDB Length = 395 Score = 33.1 bits (74), Expect = 0.27, Method: Compositional matrix adjust. Identities = 28/113 (24%), Positives = 50/113 (44%), Gaps = 18/113 (15%) Query: 51 IGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNR 110 +G +++GR + +++ D +P + + H E + L+ L L + N Sbjct: 154 LGLTLDGRDMTLVKVGDD----DPSKKSIWITARQHPGETMAEWLVEGL---LNQLLDND 206 Query: 111 NQRIVQLIQDTRIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLNRNF 163 L+ +I+P+MNPDG + G+L R NA G +LNR + Sbjct: 207 CPTSKALLDKANFYIVPNMNPDG---------SVRGHL--RTNAVGANLNREW 248 >3D4U-A nrPDB Length = 309 Score = 32.7 bits (73), Expect = 0.34, Method: Compositional matrix adjust. Identities = 32/145 (22%), Positives = 57/145 (39%), Gaps = 8/145 (5%) Query: 24 RHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVG 83 ++H +++ + + P + IG S E LYVL+ S E ++ Sbjct: 8 QYHSLNEIYSWIEVMTERYPDMVEKIHIGSSYEKYPLYVLKVSK----KEQRAKNAMWID 63 Query: 84 -NMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGP 142 +H E + L + + + + L++ +I+P +N DGY+ + Sbjct: 64 CGIHAREWISPAFCLWFVGSV-TYYYGKEKMHTNLLKHMDFYIMPVVNVDGYDYTWKKDR 122 Query: 143 --NKPGYLVGRNNANGVDLNRNFPD 165 K L +N G DLNRNF Sbjct: 123 MWRKNRSLHEKNACVGTDLNRNFAS 147 >4UEE-A nrPDB Length = 309 Score = 32.3 bits (72), Expect = 0.40, Method: Compositional matrix adjust. Identities = 31/143 (21%), Positives = 60/143 (41%), Gaps = 11/143 (7%) Query: 25 HHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGN 84 +H +++ L + E P + IG + EGR +YVL+FS P + Sbjct: 12 YHTLEEIYDFLDLLVAENPHLVSKIQIGNTYEGRPIYVLKFS----TGGSKRPAIWIDTG 67 Query: 85 MHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGPNK 144 +H E + + + ++ + +++ ++ ++ I + NPDG+ A N+ Sbjct: 68 IHSREWVTQASGVWFAKKITQDY-GQDAAFTAILDTLDIFLEIVTNPDGF--AFTHSTNR 124 Query: 145 PGYLVGRNNAN----GVDLNRNF 163 + A GVD NRN+ Sbjct: 125 MWRKTRSHTAGSLCIGVDPNRNW 147 >3OSL-A nrPDB Length = 401 Score = 32.3 bits (72), Expect = 0.48, Method: Compositional matrix adjust. Identities = 32/145 (22%), Positives = 57/145 (39%), Gaps = 8/145 (5%) Query: 24 RHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVG 83 ++H +++ + + P + IG S E LYVL+ S E ++ Sbjct: 100 QYHSLNEIYSWIEVMTERYPDMVEKIHIGSSYEKYPLYVLKVSK----KEQRAKNAMWID 155 Query: 84 -NMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGP 142 +H E + L + + + + L++ +I+P +N DGY+ + Sbjct: 156 CGIHAREWISPAFCLWFVGSVT-YYYGKEKMHTNLLKHMDFYIMPVVNVDGYDYTWKKDR 214 Query: 143 --NKPGYLVGRNNANGVDLNRNFPD 165 K L +N G DLNRNF Sbjct: 215 MWRKNRSLHEKNACVGTDLNRNFAS 239 >1J3B-A nrPDB Length = 529 Score = 32.3 bits (72), Expect = 0.49, Method: Compositional matrix adjust. Identities = 25/111 (22%), Positives = 44/111 (39%), Gaps = 5/111 (4%) Query: 248 DKLFQKLAKVYSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITL 307 +K+ + +VY GW + G FP +T +LS +++ Y F + Sbjct: 412 EKIRKHAPRVYLVNTGWTGGPYGVGYRFPLPVTRALLKAALSGALENVPYRRDPVFGFEV 471 Query: 308 ELSCDKFPPEEELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAV 358 L P E RE ++EA Q ++ + + EN+ A+ V Sbjct: 472 PLEAPGVPQELLNPRETWADKEAYDQQARKLAR-----LFQENFQKYASGV 517 >5OM9-A nrPDB Length = 419 Score = 32.0 bits (71), Expect = 0.60, Method: Compositional matrix adjust. Identities = 31/143 (21%), Positives = 60/143 (41%), Gaps = 11/143 (7%) Query: 25 HHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGN 84 +H +++ L + E P + IG + EGR +YVL+FS P + Sbjct: 122 YHTLEEIYDFLDLLVAENPHLVSKIQIGNTYEGRPIYVLKFSTGGS----KRPAIWIDTG 177 Query: 85 MHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGPNK 144 +H E + + + ++ + +++ ++ ++ I + NPDG+ A N+ Sbjct: 178 IHSREWVTQASGVWFAKKITQDY-GQDAAFTAILDTLDIFLEIVTNPDGF--AFTHSTNR 234 Query: 145 PGYLVGRNNAN----GVDLNRNF 163 + A GVD NRN+ Sbjct: 235 MWRKTRSHTAGSLCIGVDPNRNW 257 >5MRV-A nrPDB Length = 355 Score = 31.6 bits (70), Expect = 0.74, Method: Compositional matrix adjust. Identities = 31/159 (19%), Positives = 66/159 (41%), Gaps = 12/159 (7%) Query: 13 LLFKLVAPVTFRHHRYD------DLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFS 66 ++ K V+P + + Y+ ++ + ++ + + + +G + E +Y L+ S Sbjct: 38 IVDKSVSPWSLETYSYNIYHPMGEIYEWMREISEKYKEVVTQHFLGVTYETHPIYYLKIS 97 Query: 67 DHPGIHEPLEPEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHIL 126 G + + + +H E + + + + ++ N RI +L+++ ++L Sbjct: 98 QPSGNPKKI---IWMDCGIHAREWIAPAFCQWFVKEILQNHKD-NSRIRKLLRNLDFYVL 153 Query: 127 PSMNPDGYEVAAAQGPNKPGYLVGRNNAN--GVDLNRNF 163 P +N DGY NN G DLNRNF Sbjct: 154 PVLNIDGYIYTWTTDRLWRKSRSPHNNGTCFGTDLNRNF 192 >3FMC-A nrPDB Length = 368 Score = 28.9 bits (63), Expect = 4.6, Method: Compositional matrix adjust. Identities = 28/101 (27%), Positives = 46/101 (45%), Gaps = 20/101 (19%) Query: 77 PEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEV 136 P V N+HG E G ++ QL + L E + +L+ D I ++P NP G Sbjct: 34 PSVYIQANVHGAEVQGNAVIYQLMKLL-EHY--------ELLGD--ISLVPLANPLGINQ 82 Query: 137 AAAQGPNKPGYLVGR-NNANGVDLNRNFPD--LNTYIYYNE 174 + + + +GR + GV+ NR + D N ++Y E Sbjct: 83 KSGE------FTLGRFDPITGVNWNREYLDHGFNIEVWYQE 117 >1TSF-A nrPDB Length = 102 Score = 28.1 bits (61), Expect = 7.3, Method: Composition-based stats. Identities = 13/37 (35%), Positives = 20/37 (54%) Query: 318 EELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNL 354 E + R+W+G +++ GIKG V+DE N L Sbjct: 9 ELIARDWIGLMVEVVESPNHSEVGIKGEVVDETQNTL 45 >2C1C-A nrPDB Length = 312 Score = 27.7 bits (60), Expect = 9.9, Method: Compositional matrix adjust. Identities = 30/134 (22%), Positives = 53/134 (39%), Gaps = 17/134 (12%) Query: 38 VQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGNMHGNEALGRELML 97 + + P + V + S EGR + ++ S + +P + G +H E + + Sbjct: 19 IGEKYPDVATVVNAAESFEGRPIKYIKIST-TNFEDENKPVIFIDGGIHAREWISPPSVT 77 Query: 98 QLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNAN-- 155 L E+ + L++ +LP +NPDGY+ N+ + R+ N Sbjct: 78 WAIHKLVEDVTEND-----LLEKFDWILLPVVNPDGYKYTFT---NERFWRKTRSTNNNP 129 Query: 156 ------GVDLNRNF 163 G D NRNF Sbjct: 130 LSQICRGADGNRNF 143 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2NSM-A nrPDB 707 0.0 1QMU-A nrPDB 507 e-144 3MN8-A nrPDB 497 e-141 1UWY-A nrPDB 468 e-132 3V7Z-A nrPDB 299 1e-81 2BOA-A nrPDB 265 3e-71 4BD9-A nrPDB 265 4e-71 1AYE-A nrPDB 241 6e-64 1DTD-A nrPDB 237 8e-63 3KGQ-A nrPDB 233 9e-62 1JQG-A nrPDB 174 5e-44 4A39-A nrPDB 112 3e-25 5AQ0-A nrPDB 106 3e-23 5HXD-A nrPDB 101 9e-22 Sequences not found previously or not previously below threshold: 1PCA-A nrPDB 213 1e-55 5OM9-A nrPDB 211 4e-55 4UEE-A nrPDB 211 4e-55 1ZLI-A nrPDB 168 4e-42 1KWM-A nrPDB 168 6e-42 3OSL-A nrPDB 163 2e-40 3D4U-A nrPDB 163 2e-40 3GLJ-A nrPDB 163 2e-40 3LMS-A nrPDB 163 2e-40 1NSA-A nrPDB 162 3e-40 3D68-A nrPDB 160 1e-39 4UIB-A nrPDB 160 1e-39 5MRV-A nrPDB 150 1e-36 2C1C-A nrPDB 146 2e-35 1CPB-B nrPDB 116 3e-26 4B6Z-A nrPDB 90 1e-18 3K2K-A nrPDB 90 2e-18 3L2N-A nrPDB 81 1e-15 4AXV-A nrPDB 69 5e-12 1CPB-A nrPDB 57 1e-08 3B2Y-A nrPDB 41 0.001 3IEH-A nrPDB 37 0.012 4RWR-A nrPDB 36 0.049 1J3B-A nrPDB 33 0.23 6IRA-D nrPDB 33 0.27 2C2J-A nrPDB 32 0.36 4KCB-A nrPDB 32 0.41 5VOC-B nrPDB 32 0.74 2WV9-A nrPDB 31 0.93 4RGZ-A nrPDB 31 1.4 3VSL-A nrPDB 29 4.3 2VYC-A nrPDB 29 4.5 >2NSM-A nrPDB Length = 439 Score = 707 bits (1825), Expect = 0.0, Method: Composition-based stats. Identities = 434/438 (99%), Positives = 437/438 (99%) Query: 21 VTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVK 80 + FRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVK Sbjct: 2 LAFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVK 61 Query: 81 YVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQ 140 YVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQ Sbjct: 62 YVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQ 121 Query: 141 GPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRAV 200 GPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRAV Sbjct: 122 GPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRAV 181 Query: 201 IRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVYSY 260 IRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVYSY Sbjct: 182 IRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVYSY 241 Query: 261 AHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKFPPEEEL 320 AHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKFPPEEEL Sbjct: 242 AHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKFPPEEEL 301 Query: 321 QREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAVISVSGINHDVTSGDHGDYFRLL 380 QREWLGN+EALIQFLEQVHQGIKGMVLD+NYNNLANAVISVSGINHDVTSGDHGDYFRLL Sbjct: 302 QREWLGNKEALIQFLEQVHQGIKGMVLDQNYNNLANAVISVSGINHDVTSGDHGDYFRLL 361 Query: 381 LPGIYTVSATAPGYDPETVTVTVGPAEPTLVNFHLKRSIPQVSPVRRAPSRRHGVRAKVQ 440 LPGIYTVSATAPGYDPETVTVTVGPAEPTLVNFHLKRSIPQVSPVRRAPSRRHGVRAKVQ Sbjct: 362 LPGIYTVSATAPGYDPETVTVTVGPAEPTLVNFHLKRSIPQVSPVRRAPSRRHGVRAKVQ 421 Query: 441 PQARKKEMEMRQLQRGPA 458 PQARKKEMEMRQLQRGPA Sbjct: 422 PQARKKEMEMRQLQRGPA 439 >1QMU-A nrPDB Length = 380 Score = 507 bits (1305), Expect = e-144, Method: Composition-based stats. Identities = 204/409 (49%), Positives = 263/409 (64%), Gaps = 35/409 (8%) Query: 16 KLVAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPL 75 + V PV FRHH + D+ L + NE P ITR+YS+G+SVE R LYV+E SD+PGIHE Sbjct: 1 QAVQPVDFRHHHFSDMEIFLRRYANEYPSITRLYSVGKSVELRELYVMEISDNPGIHEAG 60 Query: 76 EPEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYE 135 EPE KY+GNMHGNE +GREL+L L E+LC+ F + + L+Q TRIHI+PSMNPDGYE Sbjct: 61 EPEFKYIGNMHGNEVVGRELLLNLIEYLCKNF-GTDPEVTDLVQSTRIHIMPSMNPDGYE 119 Query: 136 VAAAQGPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEP 195 + G VGRNN+N DLNRNFPD + D +P Sbjct: 120 KSQEGDR---GGTVGRNNSNNYDLNRNFPD---------------QFFQVTD----PPQP 157 Query: 196 ETRAVIRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLA 255 ET AV+ W+ ++ FVLSANLHGG++V NYP+D +G+ + +PDD +FQ+LA Sbjct: 158 ETLAVMSWLKTYPFVLSANLHGGSLVVNYPFDDD----EQGI--AIYSKSPDDAVFQQLA 211 Query: 256 KVYSYAHGWMFQGWNCGD-----YFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELS 310 YS + M+QG C D YFP GITNGA WY++ GMQD+NYL+TNCFE+T+EL Sbjct: 212 LSYSKENKKMYQGSPCKDLYPTEYFPHGITNGAQWYNVPGGMQDWNYLNTNCFEVTIELG 271 Query: 311 CDKFPPEEELQREWLGNREALIQFLEQVHQGIKGMVLDE-NYNNLANAVISVSGINHDVT 369 C K+P EEL + W NR +L+QF++QVH+GI G VLD + + NA ISV+ INH VT Sbjct: 272 CVKYPKAEELPKYWEQNRRSLLQFIKQVHRGIWGFVLDATDGRGILNATISVADINHPVT 331 Query: 370 SGDHGDYFRLLLPGIYTVSATAPGYDPETVTVTVGPAEPTLVNFHLKRS 418 + GDY+RLL+ G Y V+A+A GYDP T TV V VNF L R+ Sbjct: 332 TYKDGDYWRLLVQGTYKVTASARGYDPVTKTVEVDSKGGVQVNFTLSRT 380 >3MN8-A nrPDB Length = 435 Score = 497 bits (1278), Expect = e-141, Method: Composition-based stats. Identities = 164/404 (40%), Positives = 234/404 (57%), Gaps = 27/404 (6%) Query: 17 LVAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLE 76 L P + +DL L K P +V+ +GRS+EGR+L L+ S + L Sbjct: 35 LQQPHYASQEQLEDLFAGLEKA---YPNQAKVHFLGRSLEGRNLLALQISRNTRSRNLLT 91 Query: 77 PEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEV 136 P VKY+ NMHG+E +GR+L++ ++++L R + QL+ T I+++P+MNPDGY + Sbjct: 92 PPVKYIANMHGDETVGRQLLVYMAQYLLGN-HERISDLGQLVNSTDIYLVPTMNPDGYAL 150 Query: 137 AAAQGPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQV-EP 195 + VGR NA +DLNR+FPD + ++ ++Q +P Sbjct: 151 SQEGNCESLPNYVGRGNAANIDLNRDFPDRLEQSHVHQ--------------LRAQSRQP 196 Query: 196 ETRAVIRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLA 255 ET A++ W+ S FVLSAN HGGAVVA+YPYD S H + TPDD++F++LA Sbjct: 197 ETAALVNWIVSKPFVLSANFHGGAVVASYPYDNSLAHN----ECCEESLTPDDRVFKQLA 252 Query: 256 KVYSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKFP 315 YS H M +G NC D F GITNGA WY LS GMQDFNY +NCFE+T+ELSC K+P Sbjct: 253 HTYSDNHPIMRKGNNCNDSFSGGITNGAHWYELSGGMQDFNYAFSNCFELTIELSCCKYP 312 Query: 316 PEEELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAVISVSGINH-DVTSGDHG 374 L +EW N+ +L+Q L Q H GIKG+V D + +A+A + V+G+ + + G Sbjct: 313 AASTLPQEWQRNKASLLQLLRQAHIGIKGLVTDASGFPIADANVYVAGLEEKPMRTSKRG 372 Query: 375 DYFRLLLPGIYTVSATAPGYD---PETVTVTVGPAEPTLVNFHL 415 +Y+RLL PG+Y+V A+A GY P+ V VT E ++F L Sbjct: 373 EYWRLLTPGLYSVHASAFGYQTSAPQQVRVTNDNQEALRLDFKL 416 >1UWY-A nrPDB Length = 426 Score = 468 bits (1205), Expect = e-132, Method: Composition-based stats. Identities = 167/387 (43%), Positives = 229/387 (59%), Gaps = 30/387 (7%) Query: 21 VTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVK 80 + F +HR + + L V +T ++SIG+SV+GR+L+VL P H PE K Sbjct: 1 LDFNYHRQEGMEAFLKTVAQNYSSVTHLHSIGKSVKGRNLWVLVVGRFPKEHRIGIPEFK 60 Query: 81 YVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQ 140 YV NMHG+E +GREL+L L ++L ++ I LI TRIHI+PSMNPDG+E A + Sbjct: 61 YVANMHGDETVGRELLLHLIDYLVTS-DGKDPEITNLINSTRIHIMPSMNPDGFE--AVK 117 Query: 141 GPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRAV 200 P+ Y +GR N N DLNRNFPD Y +N Q PET AV Sbjct: 118 KPDC-YYSIGRENYNQYDLNRNFPDAFEY-----------------NNVSRQ--PETVAV 157 Query: 201 IRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVYSY 260 ++W+ + FVLSANLHGGA+VA+YP+D + R + TPDD +FQ LA Y+ Sbjct: 158 MKWLKTETFVLSANLHGGALVASYPFDNGVQATGALYSR---SLTPDDDVFQYLAHTYAS 214 Query: 261 AHGWMFQGWNCGDY--FPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKFPPEE 318 + M +G C + FP+G+TNG SWY L GMQD+NY+ CFEITLELSC K+P EE Sbjct: 215 RNPNMKKGDECKNKMNFPNGVTNGYSWYPLQGGMQDYNYIWAQCFEITLELSCCKYPREE 274 Query: 319 ELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAVISVSGINHDV--TSGDHGDY 376 +L W N+ +LI++++QVH G+KG V D+N N L N ++ V H + +G+Y Sbjct: 275 KLPSFWNNNKASLIEYIKQVHLGVKGQVFDQNGNPLPNVIVEVQDRKHICPYRTNKYGEY 334 Query: 377 FRLLLPGIYTVSATAPGYDPETVTVTV 403 + LLLPG Y ++ T PG+DP V + Sbjct: 335 YLLLLPGSYIINVTVPGHDPHITKVII 361 >3V7Z-A nrPDB Length = 326 Score = 299 bits (766), Expect = 1e-81, Method: Composition-based stats. Identities = 85/333 (25%), Positives = 141/333 (42%), Gaps = 42/333 (12%) Query: 22 TFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKY 81 +H Y+++V + V + P I + +SIG+S EGR L+ ++ SD+ G E EPEV Y Sbjct: 6 DSGYHNYNEMVNKINTVASNYPNIVKKFSIGKSYEGRELWAVKISDNVGTDEN-EPEVLY 64 Query: 82 VGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQG 141 H E L E+ L + + + N + RI L+ + I+I+ ++NPDG E + G Sbjct: 65 TALHHAREHLTVEMALYTLDLFTQNY-NLDSRITNLVNNREIYIVFNINPDGGEYDISSG 123 Query: 142 PNKPGYLVGRNNAN----GVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPET 197 K + N+ G DLNRN+ Y + + + PET Sbjct: 124 SYKSWRKNRQPNSGSSYVGTDLNRNY----GYKWGCCGGSSGSPSSETYRGRSAFSAPET 179 Query: 198 RAVIRWMHSF------NFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDD-KL 250 A+ +++S H + + YPY ++ S T DD + Sbjct: 180 AAMRDFINSRVVGGKQQIKTLITFHTYSELILYPYGYTYTD-------VPSDMTQDDFNV 232 Query: 251 FQKLAKVYSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELS 310 F+ +A + +G+ Q D + IT+G M D+ Y F T E+ Sbjct: 233 FKTMANTMAQTNGYTPQ--QASDLY---ITDG--------DMTDWAYGQHKIFAFTFEMY 279 Query: 311 CDK-----FPPEEELQREWLGNREALIQFLEQV 338 +PP+E + RE N+EA++ E+ Sbjct: 280 PTSYNPGFYPPDEVIGRETSRNKEAVLYVAEKA 312 >2BOA-A nrPDB Length = 404 Score = 265 bits (677), Expect = 3e-71, Method: Composition-based stats. Identities = 65/292 (22%), Positives = 110/292 (37%), Gaps = 32/292 (10%) Query: 22 TFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKY 81 +H + + + + + P + R IG S E R +YVL+FS G+ P V Sbjct: 103 YGAYHSLEAIYHEMDNIAADFPDLARRVKIGHSFENRPMYVLKFSTGKGVR---RPAVWL 159 Query: 82 VGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQG 141 +H E + + + + + +++ R+ I +++ I +LP NPDGY Q Sbjct: 160 NAGIHSREWISQATAIWTARKIVSDYQ-RDPAITSILEKMDIFLLPVANPDGYVYTQTQN 218 Query: 142 P--NKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRA 199 K ++ G D NRN+ K N + + E E ++ Sbjct: 219 RLWRKTRSRNPGSSCIGADPNRNWNASFA-----GKGASDNPCSEVYHGPHANSEVEVKS 273 Query: 200 VIRWMHSF-NFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVY 258 V+ ++ NF +LH + + YPY S + A DK+ + AK Sbjct: 274 VVDFIQKHGNFKGFIDLHSYSQLLMYPYGYSV--------KKAPDAEELDKVARLAAKAL 325 Query: 259 SYAHGWMFQ-GWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLEL 309 + G +Q G C +P S D+ Y + F T EL Sbjct: 326 ASVSGTEYQVGPTCTTVYPA-----------SGSSIDWAYDNGIKFAFTFEL 366 >4BD9-A nrPDB Length = 310 Score = 265 bits (676), Expect = 4e-71, Method: Composition-based stats. Identities = 65/292 (22%), Positives = 110/292 (37%), Gaps = 32/292 (10%) Query: 22 TFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKY 81 +H + + + + + P + R IG S E R +YVL+FS G+ P V Sbjct: 9 YGAYHSLEAIYHEMDNIAADFPDLARRVKIGHSFENRPMYVLKFSTGKGVR---RPAVWL 65 Query: 82 VGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQG 141 +H E + + + + + +++ R+ I +++ I +LP NPDGY Q Sbjct: 66 NAGIHSREWISQATAIWTARKIVSDYQ-RDPAITSILEKMDIFLLPVANPDGYVYTQTQN 124 Query: 142 P--NKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRA 199 K ++ G D NRN+ K N + + E E ++ Sbjct: 125 RLWRKTRSRNPGSSCIGADPNRNWNASFA-----GKGASDNPCSEVYHGPHANSEVEVKS 179 Query: 200 VIRWMHSF-NFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVY 258 V+ ++ NF +LH + + YPY S + A DK+ + AK Sbjct: 180 VVDFIQKHGNFKGFIDLHSYSQLLMYPYGYSV--------KKAPDAEELDKVARLAAKAL 231 Query: 259 SYAHGWMFQ-GWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLEL 309 + G +Q G C +P S D+ Y + F T EL Sbjct: 232 ASVSGTEYQVGPTCTTVYPA-----------SGSSIDWAYDNGIKFAFTFEL 272 >1AYE-A nrPDB Length = 401 Score = 241 bits (614), Expect = 6e-64, Method: Composition-based stats. Identities = 66/321 (20%), Positives = 120/321 (37%), Gaps = 50/321 (15%) Query: 25 HHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGN 84 +H +++ + + + E PG+ +IG S E R + VL+FS +P + Sbjct: 105 YHTLEEISQEMDNLVAEHPGLVSKVNIGSSFENRPMNVLKFSTGGD-----KPAIWLDAG 159 Query: 85 MHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGP-- 142 +H E + + L + + ++ ++ I ++ I +LP NPDGY + + Sbjct: 160 IHAREWVTQATALWTANKIVSDY-GKDPSITSILDALDIFLLPVTNPDGYVFSQTKNRMW 218 Query: 143 NKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHL-PLPD---NWKSQVEPETR 198 K V + GVD NRN ++ +GGP P D + E E + Sbjct: 219 RKTRSKVSGSLCVGVDPNRN---------WDAGFGGPGASSNPCSDSYHGPSANSEVEVK 269 Query: 199 AVIRWMHSFNFVL-SANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKV 257 +++ ++ S V LH + + +PY ++ QK A+ Sbjct: 270 SIVDFIKSHGKVKAFIILHSYSQLLMFPYGYKCT--------KLDDFDELSEVAQKAAQS 321 Query: 258 YSYAHGWMFQ-GWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCD-KF- 314 HG ++ G C Y S G D++Y + + EL ++ Sbjct: 322 LRSLHGTKYKVGPICSVI-----------YQASGGSIDWSYDYGIKYSFAFELRDTGRYG 370 Query: 315 ---PPEEELQ---REWLGNRE 329 P + L WLG + Sbjct: 371 FLLPARQILPTAEETWLGLKA 391 >1DTD-A nrPDB Length = 303 Score = 237 bits (604), Expect = 8e-63, Method: Composition-based stats. Identities = 67/322 (20%), Positives = 121/322 (37%), Gaps = 51/322 (15%) Query: 25 HHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGN 84 +H +++ + + + E PG+ +IG S E R + VL+FS +P + Sbjct: 6 YHTLEEISQEMDNLVAEHPGLVSKVNIGSSFENRPMNVLKFSTGGD-----KPAIWLDAG 60 Query: 85 MHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGP-- 142 +H E + + L + + ++ ++ I ++ I +LP NPDGY + + Sbjct: 61 IHAREWVTQATALWTANKIVSDY-GKDPSITSILDALDIFLLPVTNPDGYVFSQTKNRMW 119 Query: 143 NKPGYLVG-RNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHL-PLPD---NWKSQVEPET 197 K V + GVD NRN ++ +GGP P D + E E Sbjct: 120 RKTRSKVSAGSLCVGVDPNRN---------WDAGFGGPGASSNPCSDSYHGPSANSEVEV 170 Query: 198 RAVIRWMHSFNFVL-SANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAK 256 ++++ ++ S V LH + + +PY ++ QK A+ Sbjct: 171 KSIVDFIKSHGKVKAFIILHSYSQLLMFPYGYKCT--------KLDDFDELSEVAQKAAQ 222 Query: 257 VYSYAHGWMFQ-GWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCD-KF 314 S HG ++ G C Y S G D++Y + + EL ++ Sbjct: 223 SLSRLHGTKYKVGPICSVI-----------YQASGGSIDWSYDYGIKYSFAFELRDTGRY 271 Query: 315 ----PPEEELQ---REWLGNRE 329 P + L WLG + Sbjct: 272 GFLLPARQILPTAEETWLGLKA 293 >3KGQ-A nrPDB Length = 309 Score = 233 bits (595), Expect = 9e-62, Method: Composition-based stats. Identities = 53/291 (18%), Positives = 108/291 (37%), Gaps = 31/291 (10%) Query: 22 TFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKY 81 +H D++ + + E P + IGRS EGR +YVL+FS P + Sbjct: 9 YATYHTLDEIYDFMDLLVAEHPQLVSKLQIGRSYEGRPIYVLKFSTGGSNR----PAIWI 64 Query: 82 VGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQG 141 +H E + + + ++ E++ ++ ++ I + NPDG+ +Q Sbjct: 65 DLGIHSREWITQATGVWFAKKFTEDY-GQDPSFTAILDSMDIFLEIVTNPDGFAFTHSQN 123 Query: 142 P--NKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRA 199 K + + GVD NRN+ + + E E ++ Sbjct: 124 RLWRKTRSVTSSSLCVGVDANRNWDAGFGKA-----GASSSPCSETYHGKYANSEVEVKS 178 Query: 200 VIRWMHSF-NFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVY 258 ++ ++ NF ++H + + YPY + ++ T +++ + + Sbjct: 179 IVDFVKDHGNFKAFLSIHSYSQLLLYPYGYT--------TQSIPDKTELNQVAKSAVEAL 230 Query: 259 SYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLEL 309 +G ++ + IT + Y S G D++Y + T EL Sbjct: 231 KSLYGTSYK-------YGSIIT---TIYQASGGSIDWSYNQGIKYSFTFEL 271 >1PCA-A nrPDB Length = 403 Score = 213 bits (543), Expect = 1e-55, Method: Composition-based stats. Identities = 47/291 (16%), Positives = 101/291 (34%), Gaps = 31/291 (10%) Query: 22 TFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKY 81 +H +++ + + E P + IGRS EGR +YVL+FS P + Sbjct: 104 YATYHTLEEIYDFMDILVAEHPALVSKLQIGRSYEGRPIYVLKFSTGGSNR----PAIWI 159 Query: 82 VGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQG 141 +H E + + + ++ + E + +N ++ I + NP+G+ + Sbjct: 160 DSGIHSREWITQASGVWFAKKITENY-GQNSSFTAILDSMDIFLEIVTNPNGFAFTHSDN 218 Query: 142 P--NKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRA 199 K + G D NRN+ + E E ++ Sbjct: 219 RLWRKTRSKASGSLCVGSDSNRNWDAGFG-----GAGASSSPCAETYHGKYPNSEVEVKS 273 Query: 200 VIRWMHSF-NFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVY 258 + ++ + N ++H + + YPY ++ + + +++ + Sbjct: 274 ITDFVKNNGNIKAFISIHSYSQLLLYPYGYK--------TQSPADKSELNQIAKSAVAAL 325 Query: 259 SYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLEL 309 +G ++ + IT Y S G+ D+ Y + + EL Sbjct: 326 KSLYGTSYK-------YGSIIT---VIYQASGGVIDWTYNQGIKYSFSFEL 366 >5OM9-A nrPDB Length = 419 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 50/291 (17%), Positives = 98/291 (33%), Gaps = 31/291 (10%) Query: 22 TFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKY 81 +H +++ L + E P + IG + EGR +YVL+FS P + Sbjct: 119 YATYHTLEEIYDFLDLLVAENPHLVSKIQIGNTYEGRPIYVLKFSTGGSKR----PAIWI 174 Query: 82 VGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQG 141 +H E + + + ++ + +++ ++ ++ I + NPDG+ + Sbjct: 175 DTGIHSREWVTQASGVWFAKKITQDY-GQDAAFTAILDTLDIFLEIVTNPDGFAFTHSTN 233 Query: 142 P--NKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRA 199 K + GVD NRN+ N + E E ++ Sbjct: 234 RMWRKTRSHTAGSLCIGVDPNRNWDAGFGL-----SGASSNPCSETYHGKFANSEVEVKS 288 Query: 200 VIRWMHSF-NFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVY 258 ++ ++ N ++H + + YPY E D+L + Sbjct: 289 IVDFVKDHGNIKAFISIHSYSQLLMYPYGYKTEP--------VPDQDELDQLSKAAVTAL 340 Query: 259 SYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLEL 309 + +G F + I + Y S D+ Y + T EL Sbjct: 341 ASLYGTKFN-------YGSII---KAIYQASGSTIDWTYSQGIKYSFTFEL 381 >4UEE-A nrPDB Length = 309 Score = 211 bits (537), Expect = 4e-55, Method: Composition-based stats. Identities = 50/291 (17%), Positives = 98/291 (33%), Gaps = 31/291 (10%) Query: 22 TFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKY 81 +H +++ L + E P + IG + EGR +YVL+FS P + Sbjct: 9 YATYHTLEEIYDFLDLLVAENPHLVSKIQIGNTYEGRPIYVLKFSTGGSKR----PAIWI 64 Query: 82 VGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQG 141 +H E + + + ++ + +++ ++ ++ I + NPDG+ + Sbjct: 65 DTGIHSREWVTQASGVWFAKKITQDY-GQDAAFTAILDTLDIFLEIVTNPDGFAFTHSTN 123 Query: 142 P--NKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRA 199 K + GVD NRN+ N + E E ++ Sbjct: 124 RMWRKTRSHTAGSLCIGVDPNRNWDAGFGL-----SGASSNPCSETYHGKFANSEVEVKS 178 Query: 200 VIRWMHSF-NFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVY 258 ++ ++ N ++H + + YPY E D+L + Sbjct: 179 IVDFVKDHGNIKAFISIHSYSQLLMYPYGYKTEP--------VPDQDELDQLSKAAVTAL 230 Query: 259 SYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLEL 309 + +G F + I + Y S D+ Y + T EL Sbjct: 231 ASLYGTKFN-------YGSII---KAIYQASGSTIDWTYSQGIKYSFTFEL 271 >1JQG-A nrPDB Length = 433 Score = 174 bits (442), Expect = 5e-44, Method: Composition-based stats. Identities = 64/294 (21%), Positives = 98/294 (33%), Gaps = 42/294 (14%) Query: 26 HRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGNM 85 H Y+++ L ++ E P + V G+S EGR + L S + +P V + Sbjct: 122 HSYEEVDAYLQELAKEFPNVVTVVEGGKSFEGRSIKYLRIST-TNFQDASKPVVMMQSLL 180 Query: 86 HGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQ----- 140 H E + L L + + LI + ILP NPDGY Sbjct: 181 HCREWVTLPATLYAIHKLVIDVTESD-----LINNIDWIILPVANPDGYVHTFGGDRYWR 235 Query: 141 GPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPD---NWKSQVEPET 197 GY+ G N GVDLNRNF +G + D + EPE+ Sbjct: 236 KNRATGYMAG-NLCMGVDLNRNFG---------MNWGTASSSSVCSDTFHGRSAFSEPES 285 Query: 198 RAVIRWM--HSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLA 255 + + H L ++H + Y Y S + ++A Sbjct: 286 SVIRDIIAEHRNRMALYLDIHSFGSMILYGYGNGVL---------PSNALQLHLIGVQMA 336 Query: 256 KVYSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLEL 309 + + + DY I + Y+ S G D+ F T EL Sbjct: 337 QAIDRV-----KWSSNKDYIVGNIFH--VLYAASGGASDYAMQAAAPFSYTYEL 383 >1ZLI-A nrPDB Length = 309 Score = 168 bits (425), Expect = 4e-42, Method: Composition-based stats. Identities = 52/292 (17%), Positives = 100/292 (34%), Gaps = 32/292 (10%) Query: 22 TFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKY 81 +++ ++ + +V E P + IG + EGR +Y+L+ +P + Sbjct: 8 YEKYNNWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAG----QNKPAIFM 63 Query: 82 VGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQG 141 H E + + R ++ +L+ ++LP +N DGY + Sbjct: 64 DCGFHAREWISPAFCQWFVREAVRTY-GREIQVTELLNKLDFYVLPVLNIDGYIYTWTKS 122 Query: 142 P--NKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRA 199 K ++ G D NRNF + E N ++ E ET+A Sbjct: 123 RFWRKTRSTHTGSSCIGTDPNRNFDAG-----WCEIGASRNPCDETYCGPAAESEKETKA 177 Query: 200 VIRWMHSF--NFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKV 257 + ++ + + +H + + YPY ++ + + L + K Sbjct: 178 LADFIRNKLSSIKAYLTIHSYSQMMIYPYSYAY--------KLGENNAELNALAKATVKE 229 Query: 258 YSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLEL 309 + HG + Y P T Y + G D+ Y + T EL Sbjct: 230 LASLHGTKY------TYGPGATT----IYPAAGGSDDWAYDQGIRYSFTFEL 271 >1KWM-A nrPDB Length = 402 Score = 168 bits (424), Expect = 6e-42, Method: Composition-based stats. Identities = 52/292 (17%), Positives = 101/292 (34%), Gaps = 32/292 (10%) Query: 22 TFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKY 81 ++++++ + +V E P + IG + EGR +Y+L+ +P + Sbjct: 101 YEKYNKWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAG----QNKPAIFM 156 Query: 82 VGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQG 141 H E + + R ++ +L+ ++LP +N DGY + Sbjct: 157 DCGFHAREWISPAFCQWFVREAVRTY-GREIQVTELLNKLDFYVLPVLNIDGYIYTWTKS 215 Query: 142 P--NKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRA 199 K ++ G D NRNF + E N ++ E ET+A Sbjct: 216 RFWRKTRSTHTGSSCIGTDPNRNFDAG-----WCEIGASRNPCDETYCGPAAESEKETKA 270 Query: 200 VIRWMHSF--NFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKV 257 + ++ + + +H + + YPY ++ + + L + K Sbjct: 271 LADFIRNKLSSIKAYLTIHSYSQMMIYPYSYAY--------KLGENNAELNALAKATVKE 322 Query: 258 YSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLEL 309 + HG + Y P T Y + G D+ Y + T EL Sbjct: 323 LASLHGTKY------TYGPGATT----IYPAAGGSDDWAYDQGIRYSFTFEL 364 >3OSL-A nrPDB Length = 401 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 51/298 (17%), Positives = 101/298 (33%), Gaps = 29/298 (9%) Query: 16 KLVAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPL 75 + + ++H +++ + + P + IG S E LYVL+ S + Sbjct: 92 RASSSYYEQYHSLNEIYSWIEVMTERYPDMVEKIHIGSSYEKYPLYVLKVSKK---EQRA 148 Query: 76 EPEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYE 135 + + +H E + L + + + L++ +I+P +N DGY+ Sbjct: 149 KNAMWIDCGIHAREWISPAFCLWFVGS-VTYYYGKEKMHTNLLKHMDFYIMPVVNVDGYD 207 Query: 136 VAAAQGP--NKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQV 193 + K L +N G DLNRNF ++ + + + + Sbjct: 208 YTWKKDRMWRKNRSLHEKNACVGTDLNRNFAS----KHWCGEGASSSSCSEIYCGTYPES 263 Query: 194 EPETRAVIRWMHS--FNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLF 251 EPE +AV ++ + ++H + +PY S R + + Sbjct: 264 EPEVKAVADFLRRNIKHIKAYISMHSYSQKIVFPYSYS--------RSRSKDHEELSLVA 315 Query: 252 QKLAKVYSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLEL 309 ++ H + + G + S Y G D+ Y + T EL Sbjct: 316 REAVFAMENIHRNIR--------YTHG-SGSESLYLAPGGSDDWIYDLGIKYSFTFEL 364 >3D4U-A nrPDB Length = 309 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 51/292 (17%), Positives = 99/292 (33%), Gaps = 29/292 (9%) Query: 22 TFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKY 81 ++H +++ + + P + IG S E LYVL+ S + + + Sbjct: 6 YEQYHSLNEIYSWIEVMTERYPDMVEKIHIGSSYEKYPLYVLKVSKK---EQRAKNAMWI 62 Query: 82 VGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQG 141 +H E + L + + + L++ +I+P +N DGY+ + Sbjct: 63 DCGIHAREWISPAFCLWFVGS-VTYYYGKEKMHTNLLKHMDFYIMPVVNVDGYDYTWKKD 121 Query: 142 P--NKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRA 199 K L +N G DLNRNF ++ + + + + EPE +A Sbjct: 122 RMWRKNRSLHEKNACVGTDLNRNFAS----KHWCGEGASSSSCSEIYCGTYPESEPEVKA 177 Query: 200 VIRWMHS--FNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKV 257 V ++ + ++H + +PY S R + + ++ Sbjct: 178 VADFLRRNIKHIKAYISMHSYSQKIVFPYSYS--------RSRSKDHEELSLVAREAVFA 229 Query: 258 YSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLEL 309 H + + G + S Y G D+ Y + T EL Sbjct: 230 MENIHRNIR--------YTHG-SGSESLYLAPGGSDDWIYDLGIKYSFTFEL 272 >3GLJ-A nrPDB Length = 401 Score = 163 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 48/292 (16%), Positives = 97/292 (33%), Gaps = 32/292 (10%) Query: 22 TFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKY 81 +++ ++ + +V +E P + +IG + G ++Y+L+ PG P +P + Sbjct: 101 YEKYNNWETIEAWTKQVTSENPDLISRTAIGTTFLGNNIYLLKVGK-PG---PNKPAIFM 156 Query: 82 VGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQG 141 H E + + + + + ++LP +N DGY + Sbjct: 157 DCGFHAREWISHAFCQWFVREAVLTY-GYESHMTEFLNKLDFYVLPVLNIDGYIYTWTKN 215 Query: 142 P--NKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRA 199 K G D NRNF + + ++ E ET+A Sbjct: 216 RMWRKTRSTNAGTTCIGTDPNRNFDAG-----WCTTGASTDPCDETYCGSAAESEKETKA 270 Query: 200 VIRWMHSF--NFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKV 257 + ++ + + +H + + YPY + + + L + K Sbjct: 271 LADFIRNNLSSIKAYLTIHSYSQMILYPYSYDY--------KLPENNAELNNLAKAAVKE 322 Query: 258 YSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLEL 309 + +G + Y P T Y + G D+ Y + T EL Sbjct: 323 LATLYGTKY------TYGPGATT----IYPAAGGSDDWAYDQGIKYSFTFEL 364 >3LMS-A nrPDB Length = 309 Score = 163 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 50/297 (16%), Positives = 99/297 (33%), Gaps = 29/297 (9%) Query: 17 LVAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLE 76 A ++H +++ + + P + IG S E LYVL+ S G + + Sbjct: 1 ASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVS---GKEQAAK 57 Query: 77 PEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEV 136 + +H E + L + + F + L++ +++P +N DGY+ Sbjct: 58 NAIWIDCGIHAREWISPAFCLWFIGHITQ-FYGIIGQYTNLLRLVDFYVMPVVNVDGYDY 116 Query: 137 AAAQGP--NKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVE 194 + + K N+ G DLNRNF ++ E+ + + E Sbjct: 117 SWKKNRMWRKNRSFYANNHCIGTDLNRNFAS----KHWCEEGASSSSCSETYCGLYPESE 172 Query: 195 PETRAVIRWMHS--FNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQ 252 PE +AV ++ ++H + +PY + R + + Sbjct: 173 PEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYT--------RSKSKDHEELSLVAS 224 Query: 253 KLAKVYSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLEL 309 + + + G + Y G D+ Y + T+EL Sbjct: 225 EAVRAIEKTSKNTR--------YTHG-HGSETLYLAPGGGDDWIYDLGIKYSFTIEL 272 >1NSA-A nrPDB Length = 395 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 47/292 (16%), Positives = 102/292 (34%), Gaps = 32/292 (10%) Query: 22 TFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKY 81 +++ ++ + +V ++ P + +IG + +G ++Y+L+ PG + +P + Sbjct: 95 YEKYNNWETIEAWTEQVTSKNPDLISRSAIGTTFDGDNIYLLKVGK-PGSN---KPAIFM 150 Query: 82 VGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQG 141 H E + + + + + + + ++LP +N DGY + Sbjct: 151 DCGFHAREWISQAFCQWFVRDAVRTY-GYEAHMTEFLDNLDFYVLPVLNIDGYIYTWTKN 209 Query: 142 P--NKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRA 199 K ++ G D NRNF + N ++ E ET+A Sbjct: 210 RMWRKTRSTNAGSSCTGTDPNRNFNAG-----WCTVGASVNPCNETYCGSAAESEKETKA 264 Query: 200 VIRWMHSF--NFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKV 257 + ++ + + +H + + YPY + + + L + K Sbjct: 265 LADFIRNNLSSIKAYLTIHSYSQMILYPYSYDY--------KLPENDAELNSLAKGAVKE 316 Query: 258 YSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLEL 309 + +G + Y P T Y + G D+ Y + T EL Sbjct: 317 LASLYGTSY------SYGPGSTT----IYPAAGGSDDWAYNQGIKYSFTFEL 358 >3D68-A nrPDB Length = 424 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 50/298 (16%), Positives = 101/298 (33%), Gaps = 29/298 (9%) Query: 16 KLVAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPL 75 + A ++H +++ + + P + IG S E LYVL+ S G + Sbjct: 115 RASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVS---GKEQTA 171 Query: 76 EPEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYE 135 + + +H E + L + + F + L++ +++P +N DGY+ Sbjct: 172 KNAIWIDCGIHAREWISPAFCLWFIGHITQ-FYGIIGQYTNLLRLVDFYVMPVVNVDGYD 230 Query: 136 VAAAQGP--NKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQV 193 + + K N+ G DLNRNF ++ E+ + + Sbjct: 231 YSWKKNRMWRKNRSFYANNHCIGTDLNRNFAS----KHWCEEGASSSSCSETYCGLYPES 286 Query: 194 EPETRAVIRWMHS--FNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLF 251 EPE +AV ++ ++H + +PY + R + + Sbjct: 287 EPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPYSYT--------RSKSKDHEELSLVA 338 Query: 252 QKLAKVYSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLEL 309 + + + + G + Y G D+ Y + T+EL Sbjct: 339 SEAVRAIEKISKNIR--------YTYG-QGSETLYLAPGGGDDWIYDLGIKYSFTIEL 387 >4UIB-A nrPDB Length = 307 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 48/292 (16%), Positives = 97/292 (33%), Gaps = 32/292 (10%) Query: 22 TFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKY 81 +++ ++ + +V +E P + +IG + G ++Y+L+ PG P +P + Sbjct: 6 YEKYNNWETIEAWTKQVTSENPDLISRTAIGTTFLGNNIYLLKVGK-PG---PNKPAIFM 61 Query: 82 VGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQG 141 +H E + + + + + ++LP +N DGY + Sbjct: 62 DCGIHAREWISHAFCQWFVREAVLTY-GYESHMTEFLNKLDFYVLPVLNIDGYIYTWTKN 120 Query: 142 P--NKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRA 199 K G D NRNF + + ++ E ET+A Sbjct: 121 RMWRKTRSTNAGTTCIGTDPNRNFDAG-----WCTTGASTDPCDETYCGSAAESEKETKA 175 Query: 200 VIRWMHSF--NFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKV 257 + ++ + + ++H + YPY + + + L + K Sbjct: 176 LADFIRNNLSSIKAYLSIHSYSQHIVYPYSYDY--------KLPENNAELNNLAKAAVKE 227 Query: 258 YSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLEL 309 + +G + Y P T Y G D+ Y + T EL Sbjct: 228 LATLYGTKY------TYGPGATT----LYLAPGGGDDWAYDQGIKYSFTFEL 269 >5MRV-A nrPDB Length = 355 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 57/323 (17%), Positives = 107/323 (33%), Gaps = 35/323 (10%) Query: 25 HHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGN 84 +H ++ + ++ + + + +G + E +Y L+ S G + + Sbjct: 56 YHPMGEIYEWMREISEKYKEVVTQHFLGVTYETHPIYYLKISQPSG---NPKKIIWMDCG 112 Query: 85 MHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGP-- 142 +H E + + + + N RI +L+++ ++LP +N DGY Sbjct: 113 IHAREWIAPAFCQWFVKEILQN-HKDNSRIRKLLRNLDFYVLPVLNIDGYIYTWTTDRLW 171 Query: 143 NKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRAVIR 202 K G DLNRNF + N EPET+AV Sbjct: 172 RKSRSPHNNGTCFGTDLNRNFNAS-----WCSIGASRNCQDQTFCGTGPVSEPETKAVAS 226 Query: 203 WMHSFN--FVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVYSY 260 ++ S + +H + PY + ++ QK A Sbjct: 227 FIESKKDDILCFLTMHSYGQLILTPYGYTKNKSSNHPEMI--------QVGQKAANALKA 278 Query: 261 AHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDK----FPP 316 +G ++ + D Y+ S +D+ F T EL P Sbjct: 279 KYGTNYRVGSSADIL----------YASSGSSRDWARDIGIPFSYTFELRDSGTYGFVLP 328 Query: 317 EEELQREWLGNREALIQFLEQVH 339 E ++Q EA++ L+ V+ Sbjct: 329 EAQIQPTCEETMEAVLSVLDDVY 351 >2C1C-A nrPDB Length = 312 Score = 146 bits (368), Expect = 2e-35, Method: Composition-based stats. Identities = 51/299 (17%), Positives = 92/299 (30%), Gaps = 37/299 (12%) Query: 20 PVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEV 79 P + + + L + + P + V + S EGR + ++ S + +P + Sbjct: 2 PYD-NYQELEVIDEYLDYIGEKYPDVATVVNAAESFEGRPIKYIKIST-TNFEDENKPVI 59 Query: 80 KYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAA 139 G +H E + + L E+ + L++ +LP +NPDGY+ Sbjct: 60 FIDGGIHAREWISPPSVTWAIHKLVEDVTEND-----LLEKFDWILLPVVNPDGYKYTFT 114 Query: 140 QGP--NKPGYLVGRNN---ANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVE 194 K G D NRNF +N + + + E Sbjct: 115 NERFWRKTRSTNNNPLSQICRGADGNRNF-----DFVWNSIGTSNSPCSDIYAGTSAFSE 169 Query: 195 PETRAVIRWMHSF--NFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQ 252 ETR V +H L +H + YP+ + Sbjct: 170 VETRVVRDILHEHLARMALYLTMHSFGSMILYPWGHDGSLSQNALGL------------- 216 Query: 253 KLAKVYSYAHGWMFQGWNCGDYFPDGITNGAS--WYSLSKGMQDFNYLHTNCFEITLEL 309 A + Q ++ P + N A Y ++ +D+ + T EL Sbjct: 217 ---HTVGVAMASVIQSNALPNFPPYTVGNSALVIGYYIAGSSEDYAHSIGVPLSYTYEL 272 >1CPB-B nrPDB Length = 217 Score = 116 bits (289), Expect = 3e-26, Method: Composition-based stats. Identities = 37/201 (18%), Positives = 66/201 (32%), Gaps = 29/201 (14%) Query: 114 IVQLIQDTRIHILPSMNPDGYEVAAAQGP--NKPGYLVGRNNANGVDLNRNFPDLNTYIY 171 + + + ++LP +N DGY K ++ G DLNRNF Sbjct: 4 MTEFLDKLDFYVLPVVNIDGYIYTWTTNRMWRKTRSTRAGSSCTGTDLNRNFDAG----- 58 Query: 172 YNEKYGGPNHHLPLPDNWKSQVEPETRAVIRWMHSF--NFVLSANLHGGAVVANYPYDKS 229 + N ++ E E++AV ++ + + +H + + YPY Sbjct: 59 WCSIGASNNPCSETYCGSAAESEKESKAVADFIRNHLSSIKAYLTIHSYSQMMLYPYSYD 118 Query: 230 FEHRVRGVRRTASTPTPDDKLFQKLAKVYSYAHGWMFQ-GWNCGDYFPDGITNGASWYSL 288 ++ V + L + K + HG + G +P Sbjct: 119 YKLPKNNV--------ELNTLAKGAVKKLASLHGTTYSYGPGATTIYPA----------- 159 Query: 289 SKGMQDFNYLHTNCFEITLEL 309 S G D+ Y + T EL Sbjct: 160 SGGSDDWAYDQGIKYSFTFEL 180 >4A39-A nrPDB Length = 388 Score = 112 bits (280), Expect = 3e-25, Method: Composition-based stats. Identities = 58/290 (20%), Positives = 94/290 (32%), Gaps = 64/290 (22%) Query: 46 TRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGNMHGNEALGRELMLQLSEFLCE 105 ++G SV+GR + +L HP H L + H E + M L E L Sbjct: 144 VERLAVGTSVQGRDIELLRVRRHPDSHLKL----WVIAQQHPGEHMAEWFMEGLIERLQ- 198 Query: 106 EFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLNRNFPD 165 R + + +L++ ++++P+MNPDG A G R NA G DLNR + + Sbjct: 199 --RPDDTEMQRLLEKADLYLVPNMNPDG----AFHGNL-------RTNAAGQDLNRAWLE 245 Query: 166 LNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRAVIRWMHSFNFVLSANLHGGAVVANYP 225 ++ PE V + M L ++HG + Sbjct: 246 -----------------------PSAERSPEVWFVQQEMKRHGVDLFLDIHGDEEIP--- 279 Query: 226 YDKSFEHRVRGVRRTASTPTPDDKLFQ--KLAK-VYSYAHGWMFQGWNCGDYFPDGITNG 282 F G ++ F+ +A+ + HG+ G N Sbjct: 280 --HVFAAGCEGNPGYTPRLERLEQRFREELMARGEFQIRHGYPRSAP--------GQANL 329 Query: 283 ASWYSLSKGMQDFNYLHTNCFEITLELSCDKFPPEEELQREWLGNREALI 332 A + D C T+E+ E W G R + Sbjct: 330 ALACNFVGQTYD-------CLAFTIEMPFKDHDDNPEPGTGWSGARSKRL 372 >5AQ0-A nrPDB Length = 82 Score = 106 bits (263), Expect = 3e-23, Method: Composition-based stats. Identities = 37/78 (47%), Positives = 50/78 (64%), Gaps = 2/78 (2%) Query: 341 GIKGMVLDE-NYNNLANAVISVSGINHDVTSGDHGDYFRLLLPGIYTVSATAPGYDPETV 399 G+KG V D + L NA ISV+GINH++T+G GD++RLL+PG Y ++ GY P TV Sbjct: 2 GVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFYRLLVPGTYNLTVVLTGYMPLTV 61 Query: 400 TVTVGPAEP-TLVNFHLK 416 T V P T V+F L+ Sbjct: 62 TNVVVKEGPATEVDFSLR 79 >5HXD-A nrPDB Length = 237 Score = 101 bits (250), Expect = 9e-22, Method: Composition-based stats. Identities = 58/252 (23%), Positives = 77/252 (30%), Gaps = 49/252 (19%) Query: 52 GRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRN 111 GRS+ G L + F E + HG+E + L R Sbjct: 21 GRSLLGAPL--IWFPAPAASRESG----LILAGTHGDENSSVVTLSCALRTLTPSLR--- 71 Query: 112 QRIVQLIQDTRIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLNRNFPDLN---T 168 R H++ +NPDG ++ R NANGVDLNRNFP N Sbjct: 72 ----------RHHVVLCVNPDGCQLGL------------RANANGVDLNRNFPAANWKEG 109 Query: 169 YIYYNEKYGGPNHHLPLPDNWKSQVEPETRAVIRWMHSFNFVLSANLHGGAVVANYPYDK 228 Y + L K EPET+A+ + +H + H P Sbjct: 110 ETVYRWNSAAEERDVVLLTGDKPGSEPETQALCQLIHRIQPAWVVSFHDPLACIEDP--- 166 Query: 229 SFEHRVRGVRRTASTPTPDDKLFQKLAKVYSYAHGWMFQGWNCGDYFPDGITNGASWYSL 288 H G + P L Y F W C D IT A + + Sbjct: 167 --RHSELGEWLAQAFELP-------LVTSVGYETPGSFGSW-CADLNLHCIT--AEFPPI 214 Query: 289 SKGMQDFNYLHT 300 S YL Sbjct: 215 SSDEASEKYLFA 226 >4B6Z-A nrPDB Length = 405 Score = 90.3 bits (222), Expect = 1e-18, Method: Composition-based stats. Identities = 62/320 (19%), Positives = 104/320 (32%), Gaps = 62/320 (19%) Query: 15 FKLVAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEP 74 F + F + + L VQ P V +GR+VEGR + +L P Sbjct: 124 FDSIYYAYFEPYSEERHAAFLGAVQQ-LPQ-ASVVELGRTVEGRPMSLLTLGT-PETDGA 180 Query: 75 LEPEVKYVGNMHGNEALGRELMLQLSEFLCE--EFRNRNQRIVQLIQDTRIHILPSMNPD 132 + +V + H E++ + L + L ++ + +L HI+P+MNPD Sbjct: 181 PKKKVWIIARQHPGESMAEWFVEGLVKRLAGWGDWAG-DPVARKLYDRVTFHIVPNMNPD 239 Query: 133 GYEVAAAQGPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQ 192 G R NA G +LNR + ++ Sbjct: 240 GSVHG-----------NLRTNAAGANLNREWMA-----------------------PDAE 265 Query: 193 VEPETRAVIRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQ 252 PE AV +H+ + ++HG + Y + E + T + F+ Sbjct: 266 RSPEVLAVRDAIHAIGCDMFFDIHGDEDLP-YVFVAGSEMLPSFTEQQGKEQTAFIEAFK 324 Query: 253 KLAKVYSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCD 312 + + HG+ Y D + + + G C +TLE+ Sbjct: 325 VASPDFQTEHGYA-----ASKYKEDALKLASKYIGHQFG----------CLSLTLEM--- 366 Query: 313 KFPPEEELQRE---WLGNRE 329 F L E W G R Sbjct: 367 PFKDNANLPDERVGWNGERS 386 >3K2K-A nrPDB Length = 403 Score = 90.3 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 63/329 (19%), Positives = 106/329 (32%), Gaps = 74/329 (22%) Query: 15 FKLVAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEP 74 F + F + + L VQ P V +GR+VEGR + ++ P Sbjct: 122 FDSIHYAYFEPYSEERHSEFLGAVQQ-MPQ-ASVVELGRTVEGRPMSLVVLGT-PDEAGA 178 Query: 75 LEPEVKYVGNMHGNEALGRELMLQLSEFLCE--EFRNRNQRIVQLIQDTRIHILPSMNPD 132 + +V + H E++ + L + L ++ + +L +I+P+MNPD Sbjct: 179 AKKKVWIIARQHPGESMAEWFIEGLVKRLVGWGDWSG-DPVARKLYDHATFYIVPNMNPD 237 Query: 133 GYEVAAAQGPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQ 192 G R NA G +LNR + + ++ Sbjct: 238 GSVHG-----------NLRTNAAGANLNREWME-----------------------PDAE 263 Query: 193 VEPETRAVIRWMHSFNFVLSANLHGGAVVANYPY----DKSFEHRVRGVRRTASTPTPDD 248 PE V +H+ L ++HG + PY +R + D Sbjct: 264 RSPEVLVVRDAIHAIGCDLFFDIHGDEDL---PYVFAAGSEMLPGFTEQQRVEQSAFIDS 320 Query: 249 KLFQKLAKVYSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTN--CFEIT 306 F++ + + HG+ G D F Y+ C +T Sbjct: 321 --FKRASPDFQDEHGY-PPGKYREDAFKLAS----------------KYIGHRFGCLSLT 361 Query: 307 LELSCDKFPPEEELQRE---WLGNREALI 332 LE+ F L E W G R A + Sbjct: 362 LEM---PFKDNANLPDEHIGWNGARSASL 387 >3L2N-A nrPDB Length = 395 Score = 81.0 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 37/202 (18%), Positives = 69/202 (34%), Gaps = 43/202 (21%) Query: 16 KLVAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPL 75 + + F + Y+ + + P ++ + +G +++GR + +++ D +P Sbjct: 121 EAIQIAYFTPYSYERHLDLI-SAVQLHPLVSTEH-LGLTLDGRDMTLVKVGD----DDPS 174 Query: 76 EPEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYE 135 + + H E + L+ L L N L+ +I+P+MNPDG Sbjct: 175 KKSIWITARQHPGETMAEWLVEGLLNQLL---DNDCPTSKALLDKANFYIVPNMNPDGSV 231 Query: 136 VAAAQGPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEP 195 R NA G +LNR + + P Sbjct: 232 RGHL-----------RTNAVGANLNREW-----------------------QTPSLERSP 257 Query: 196 ETRAVIRWMHSFNFVLSANLHG 217 E V+ MH L ++HG Sbjct: 258 EVYYVVNKMHETGVDLFYDVHG 279 >4AXV-A nrPDB Length = 243 Score = 68.7 bits (166), Expect = 5e-12, Method: Composition-based stats. Identities = 38/175 (21%), Positives = 55/175 (31%), Gaps = 34/175 (19%) Query: 45 ITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGNMHGNEALGRELMLQLSEFLC 104 + S G+SV G L + HG+E + L Sbjct: 20 LITPTSYGKSVLGAPLLYFPAQVESNSRG------LILAGTHGDETASIAGLSCALRSLP 73 Query: 105 EEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLNRNFP 164 E + ++ SMNPD ++ R NAN VDLNR FP Sbjct: 74 AECLKHD-------------VILSMNPDANQLGT------------RANANQVDLNRAFP 108 Query: 165 DLNTYIY---YNEKYGGPNHHLPLPDNWKSQVEPETRAVIRWMHSFNFVLSANLH 216 N + Y P + + K Q+EPE A+I + + H Sbjct: 109 TQNWTEHGTVYRWSSHTPVRDVKVKTGDKEQLEPEVDALISLIELRRPKFVVSFH 163 >1CPB-A nrPDB Length = 82 Score = 57.1 bits (136), Expect = 1e-08, Method: Composition-based stats. Identities = 14/80 (17%), Positives = 31/80 (38%), Gaps = 4/80 (5%) Query: 22 TFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKY 81 +++ ++ + +V +E P + +IG + G +Y+L+ PG + +P V Sbjct: 6 YEKYNNWETIEAWTEQVASENPDLISRSAIGTTFLGNTIYLLKVGK-PGSN---KPAVFM 61 Query: 82 VGNMHGNEALGRELMLQLSE 101 H E + Sbjct: 62 DCGFHAREWISPAFCQWFVR 81 >3B2Y-A nrPDB Length = 275 Score = 40.9 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 28/153 (18%), Positives = 46/153 (30%), Gaps = 26/153 (16%) Query: 29 DDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGNMHGN 88 +D+ ++ E + + SV+ + + + P + HG Sbjct: 23 NDIDAFYAQLAEEVNRLGLKKNTLGSVDSFAINLYQ----SASQRSDLPSLLISSGFHGE 78 Query: 89 EALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGPNKPGYL 148 EA G ML L L + + +LP +NP G++ Sbjct: 79 EAAGPWGMLHFLRGLQP----------ALFERVNLSLLPLVNPTGFKAGH---------- 118 Query: 149 VGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNH 181 R N G + NR F N NE Sbjct: 119 --RFNRFGENPNRGFTLENGKPTPNEHTSLEGK 149 >3IEH-A nrPDB Length = 276 Score = 37.5 bits (85), Expect = 0.012, Method: Composition-based stats. Identities = 21/107 (19%), Positives = 31/107 (28%), Gaps = 22/107 (20%) Query: 75 LEPEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGY 134 P + HG E+ G +L + L + + +LP +NP G+ Sbjct: 65 GLPSLLISAGFHGEESAGPWGLLHFLSEASAD----------LFERVNLSLLPLVNPTGF 114 Query: 135 EVAAAQGPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNH 181 R N G + NR F N NE Sbjct: 115 SRGH------------RFNKYGENPNRGFVFENGKPKANEHTSVEGK 149 >4RWR-A nrPDB Length = 331 Score = 35.6 bits (80), Expect = 0.049, Method: Composition-based stats. Identities = 14/64 (21%), Positives = 30/64 (46%), Gaps = 4/64 (6%) Query: 314 FPPEEELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAVISVSGINHDVTSGDH 373 + +EEL+++W N E ++ +E+ G VL ++ + S S + + + Sbjct: 124 YKSKEELKKQWGNNYENNLKKIEEAVSKTAGQVLTYEGKPISASFFSTS----NGRTENA 179 Query: 374 GDYF 377 DY+ Sbjct: 180 ADYW 183 >1J3B-A nrPDB Length = 529 Score = 33.2 bits (74), Expect = 0.23, Method: Composition-based stats. Identities = 21/93 (22%), Positives = 37/93 (39%) Query: 248 DKLFQKLAKVYSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITL 307 +K+ + +VY GW + G FP +T +LS +++ Y F + Sbjct: 412 EKIRKHAPRVYLVNTGWTGGPYGVGYRFPLPVTRALLKAALSGALENVPYRRDPVFGFEV 471 Query: 308 ELSCDKFPPEEELQREWLGNREALIQFLEQVHQ 340 L P E RE ++EA Q ++ + Sbjct: 472 PLEAPGVPQELLNPRETWADKEAYDQQARKLAR 504 >6IRA-D nrPDB Length = 853 Score = 33.2 bits (74), Expect = 0.27, Method: Composition-based stats. Identities = 21/102 (20%), Positives = 35/102 (34%), Gaps = 3/102 (2%) Query: 135 EVAAAQGPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVE 194 E+ GP + L N + +NR P + G H L D+ + Sbjct: 50 ELRTLWGPEQAAGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEA- 108 Query: 195 PETRAVIRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRG 236 ++ ++ S FV +HGGA + D + G Sbjct: 109 --VAQMLDFISSHTFVPILGIHGGASMIMADKDPTSTFFQFG 148 >2C2J-A nrPDB Length = 211 Score = 32.5 bits (72), Expect = 0.36, Method: Composition-based stats. Identities = 16/106 (15%), Positives = 34/106 (32%), Gaps = 12/106 (11%) Query: 21 VTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVK 80 Y+ + + V R S+G S +GR + ++ S P I + + Sbjct: 82 HELLQDHYEGISKFADDVA------ERQLSVGASSDGRAITIVAASRLPEIPGGFLDDAQ 135 Query: 81 YVGNM-HGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHI 125 + + E +G+ + + L+Q+ I Sbjct: 136 VIQFFTYQYETVGQR-----IHQRVGDVEKVDPTTANLLQEVEHII 176 >4KCB-A nrPDB Length = 447 Score = 32.5 bits (72), Expect = 0.41, Method: Composition-based stats. Identities = 17/111 (15%), Positives = 29/111 (26%), Gaps = 10/111 (9%) Query: 91 LGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGPNKPGYLVG 150 + + C F I + T +NP+ + + Sbjct: 194 ISEHNGTWYMYYSCSTFGKNGSAIGLMTNKT-------LNPESPDYKWEDKGMVVRSVQR 246 Query: 151 RNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNW--KSQVEPETRA 199 + N N +D N D + L D + EP+T A Sbjct: 247 QTNWNAIDPNL-IMDEKGRPWLTWGSFWDGIQLVQLDKDFKTPKGEPKTIA 296 >5VOC-B nrPDB Length = 278 Score = 31.7 bits (70), Expect = 0.74, Method: Composition-based stats. Identities = 29/133 (21%), Positives = 37/133 (27%), Gaps = 14/133 (10%) Query: 36 YKVQNECPGITRVYSIGRSVEG-------RHLYVLEFSDHPGIHEPLEPEVKYVGNMHGN 88 KV ECP +TR +G EG R L + D P V N Sbjct: 41 EKVPAECPELTRRCLLGEVFEGDKYESWLRPLVNVTGRDGPLSQLIRYRPVTPEA---AN 97 Query: 89 EALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGPNKPGYL 148 L E L L + L DT + M + + Y Sbjct: 98 SVLLDEAFLDTLALLYNNPDQLRALLTLLSSDTAPRWMTVMR----GYSECGDGSPAVYT 153 Query: 149 VGRNNANGVDLNR 161 + G DL R Sbjct: 154 CVDDLCRGYDLTR 166 >2WV9-A nrPDB Length = 673 Score = 31.3 bits (69), Expect = 0.93, Method: Composition-based stats. Identities = 26/132 (19%), Positives = 52/132 (39%), Gaps = 17/132 (12%) Query: 334 FLEQVHQGIKGMVLD----ENYNNLANAVISVSGINHDVTSGDHGDYFRLLLPGIYTVSA 389 + H I + LD + + + N+ + G+ + +G Y ++ G Sbjct: 169 IFKTAHGEIGAVSLDYPIGTSGSPIVNSNGEIIGLYGNGVILGNGAYVSAIVQGERVEEP 228 Query: 390 TAPGYDPETVTVTVGPAEPTLVNFH-----LKRSIPQVSPVRRAPSRRHGVRAKVQPQAR 444 Y+PE + + T+++ H +R +PQ+ ++ A +R +R V R Sbjct: 229 VPEAYNPEMLK----KRQLTVLDLHPGAGKTRRILPQI--IKDAIQKR--LRTAVLAPTR 280 Query: 445 KKEMEMRQLQRG 456 EM + RG Sbjct: 281 VVAAEMAEALRG 292 >4RGZ-A nrPDB Length = 367 Score = 30.5 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 14/63 (22%), Positives = 29/63 (46%), Gaps = 13/63 (20%) Query: 315 PPEEELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAVISVSGINHDVTSGDHG 374 PP EE+++ + +EA +++V +GI V+D + ++ +G Sbjct: 246 PPSEEVKKVYEIVKEAQETAVQKVAEGIPAEVVDATARGI-------------ISKYGYG 292 Query: 375 DYF 377 +YF Sbjct: 293 EYF 295 >3VSL-A nrPDB Length = 646 Score = 29.0 bits (63), Expect = 4.3, Method: Composition-based stats. Identities = 31/156 (19%), Positives = 59/156 (37%), Gaps = 19/156 (12%) Query: 303 FEITLELSCDKFPPEEELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAVISVS 362 F+ L+L+ D + L + + L + L QV G+K +L N Sbjct: 409 FKTALKLAGDPYYSGMALPSDISSPAQKLRRGLNQVGLGVK------TGIDLPN---ETR 459 Query: 363 GINHDVTSGDHGDYFRLLLPGIYTVSATAPGYDPETVT--VTVGPAEPTLVNFHLKRSIP 420 G +T+ G+Y L + G Y Y P ++ V+ + + H+ +I Sbjct: 460 GQIEPLTNNP-GNYLDLSI-GQYDT------YTPLQLSQYVSTIANDGYRIQPHIGLTIH 511 Query: 421 QVSPVRRAPSRRHGVRAKVQPQARKKEMEMRQLQRG 456 + + + + V + E E++Q+Q G Sbjct: 512 ESTNKDEVGPLKKKINGTVLNKVNNTEKEIKQIQEG 547 >2VYC-A nrPDB Length = 755 Score = 29.0 bits (63), Expect = 4.5, Method: Composition-based stats. Identities = 17/81 (20%), Positives = 34/81 (41%), Gaps = 7/81 (8%) Query: 384 IYTVSATAPGYDPETVTVTVGPAEPTLVNFHLKRSIPQ------VSPVRRAPSR-RHGVR 436 ++V G + + + + +V+ + +SI Q PV PSR R+G+ Sbjct: 223 SWSVVVGTSGSNRTIMQACMTDNDVVVVDRNCHKSIEQGLMLTGAKPVYMVPSRNRYGII 282 Query: 437 AKVQPQARKKEMEMRQLQRGP 457 + PQ + E +++ P Sbjct: 283 GPIYPQEMQPETLQKKISESP 303 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.122 0.325 Lambda K H 0.267 0.0369 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,369,807 Number of Sequences: 36641 Number of extensions: 686529 Number of successful extensions: 2022 Number of sequences better than 10.0: 46 Number of HSP's better than 10.0 without gapping: 54 Number of HSP's successfully gapped in prelim test: 26 Number of HSP's that attempted gapping in prelim test: 1777 Number of HSP's gapped (non-prelim): 80 length of query: 458 length of database: 10,336,785 effective HSP length: 100 effective length of query: 358 effective length of database: 6,672,685 effective search space: 2388821230 effective search space used: 2388821230 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 60 (27.9 bits)