BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P14868 (501 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4J15-A nrPDB 1043 0.0 1ASZ-A nrPDB 552 e-157 3I7F-A nrPDB 498 e-141 6OD8-A nrPDB 466 e-131 1WYD-A nrPDB 286 1e-77 3NEM-A nrPDB 265 2e-71 1N9W-A nrPDB 249 2e-66 1X54-A nrPDB 218 5e-57 5ZG8-A nrPDB 176 2e-44 2XGT-A nrPDB 154 1e-37 5XIX-A nrPDB 153 2e-37 3M4P-A nrPDB 149 3e-36 1BBU-A nrPDB 106 2e-23 1LYL-A nrPDB 106 3e-23 6AQG-A nrPDB 102 3e-22 6AQH-A nrPDB 102 4e-22 3A74-A nrPDB 91 1e-18 5W25-A nrPDB 86 3e-17 5ELO-A nrPDB 86 5e-17 6ILH-A nrPDB 85 9e-17 6CHD-A nrPDB 84 1e-16 4RMF-A nrPDB 84 2e-16 4YCV-A nrPDB 82 5e-16 4EX5-A nrPDB 82 6e-16 5HGQ-A nrPDB 79 4e-15 4AH6-A nrPDB 79 4e-15 4WJ3-M nrPDB 79 5e-15 1IL2-A nrPDB 77 2e-14 6NRZ-A nrPDB 75 6e-14 1EFW-A nrPDB 74 2e-13 1NNH-A nrPDB 61 1e-09 4UP8-A nrPDB 55 7e-08 3P8T-A nrPDB 54 2e-07 3G1Z-A nrPDB 42 6e-04 3G9Q-A nrPDB 35 0.055 6JP2-A nrPDB 33 0.31 3VQX-A nrPDB 32 0.85 11AS-A nrPDB 29 5.1 6D6R-H nrPDB 28 6.7 6C70-A nrPDB 28 8.0 >4J15-A nrPDB Length = 521 Score = 1043 bits (2698), Expect = 0.0, Method: Compositional matrix adjust. Identities = 501/501 (100%), Positives = 501/501 (100%) Query: 1 MPSASASRKSQEKPREIMDAAEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADEVV 60 MPSASASRKSQEKPREIMDAAEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADEVV Sbjct: 21 MPSASASRKSQEKPREIMDAAEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADEVV 80 Query: 61 WVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVV 120 WVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVV Sbjct: 81 WVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVV 140 Query: 121 RKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRL 180 RKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRL Sbjct: 141 RKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRL 200 Query: 181 DNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYF 240 DNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYF Sbjct: 201 DNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYF 260 Query: 241 KNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYH 300 KNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYH Sbjct: 261 KNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYH 320 Query: 301 EVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGV 360 EVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGV Sbjct: 321 EVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGV 380 Query: 361 EMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFM 420 EMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFM Sbjct: 381 EMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFM 440 Query: 421 RGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLF 480 RGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLF Sbjct: 441 RGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLF 500 Query: 481 LGLHNVRQTSMFPRDPKRLTP 501 LGLHNVRQTSMFPRDPKRLTP Sbjct: 501 LGLHNVRQTSMFPRDPKRLTP 521 >1ASZ-A nrPDB Length = 490 Score = 552 bits (1423), Expect = e-157, Method: Compositional matrix adjust. Identities = 281/490 (57%), Positives = 346/490 (70%), Gaps = 10/490 (2%) Query: 22 EDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKA---DEVVWVRARVHTSRAKGKQ-CF 77 ED AK+ YG +IQS++ RV+ + + +A D+ V RARVH +R +G F Sbjct: 1 EDTAKDNYGKLPLIQSRDSDRTGQKRVKFVDLDEAKDSDKEVLFRARVHNTRQQGATLAF 60 Query: 78 LVLRQQQFNVQALVAVGDHA--SKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQQDV 135 L LRQQ +Q LV SK MVK+A ++N ESIV V G+V+KV++ I S T Q++ Sbjct: 61 LTLRQQASLIQGLVKANKEGTISKNMVKWAGSLNLESIVLVRGIVKKVDEPIKSATVQNL 120 Query: 136 ELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAV 195 E+H+ KIY IS LP+ L+DA R EAE E G VN DTRLD RVIDLRT T+QA+ Sbjct: 121 EIHITKIYTISETPEALPILLEDASRSEAEAEAAGLPVVNLDTRLDYRVIDLRTVTNQAI 180 Query: 196 FRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQ 255 FR+Q+G+C LFRE L K F E+ TPK++ A SEGG++VF V+YFK AYLAQSPQ KQ Sbjct: 181 FRIQAGVCELFREYLATKKFTEVHTPKLLGAPSEGGSSVFEVTYFKGKAYLAQSPQFNKQ 240 Query: 256 MCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIFK 315 I ADFE+V+ IGPVFRAE+SNTHRH+TEF GLD+EMAF HYHEV++ +++ V IF Sbjct: 241 QLIVADFERVYEIGPVFRAENSNTHRHMTEFTGLDMEMAFEEHYHEVLDTLSELFVFIFS 300 Query: 316 GLQERFQTEIQTVNKQFPCEPFKFLE--PTLRLEYCEALAMLREAGVEMGDEDDLSTPNE 373 L +RF EI+ V KQ+P E FK + +RL Y E + MLR AG E+GD +DLST NE Sbjct: 301 ELPKRFAHEIELVRKQYPVEEFKLPKDGKMVRLTYKEGIEMLRAAGKEIGDFEDLSTENE 360 Query: 374 KLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIH 433 K LG LV++KYDTDFYILDK+PL +RPFYTMPDP NPK SNSYD FMRGEEILSGAQRIH Sbjct: 361 KFLGKLVRDKYDTDFYILDKFPLEIRPFYTMPDPANPKYSNSYDFFMRGEEILSGAQRIH 420 Query: 434 DPQLLTERALHHGIDLEK--IKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSM 491 D LL ER HG+ E +K Y D F +G PPHAGGGIGLERV M +L L N+R+ S+ Sbjct: 421 DHALLQERMKAHGLSPEDPGLKDYCDGFSYGCPPHAGGGIGLERVVMFYLDLKNIRRASL 480 Query: 492 FPRDPKRLTP 501 FPRDPKRL P Sbjct: 481 FPRDPKRLRP 490 >3I7F-A nrPDB Length = 548 Score = 498 bits (1281), Expect = e-141, Method: Compositional matrix adjust. Identities = 257/544 (47%), Positives = 340/544 (62%), Gaps = 46/544 (8%) Query: 3 SASASRKSQEKPREIMDAAEDYAKERYGISSMIQSQE--KPDRVLVRVRDLTIQKADEVV 60 +A+ +K Q P ++ E + E + + M QSQ K + +L A++ V Sbjct: 6 AATQEKKPQLPPVVLLKTPELVSGENFKVMPMHQSQPCYKTGLKYTEIEELVPAMAEKTV 65 Query: 61 WVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVV 120 +RARV R KG FL LR+ + QALV + SK+ V+F I+ ESI D+ G+V Sbjct: 66 TIRARVQAVRGKGNMVFLFLRKGIYTCQALVMKSETISKEFVQFCQKISAESICDITGIV 125 Query: 121 RKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEA---------------- 164 + V + I TQQDVE+HV I V+SLAE LP+Q++D P + Sbjct: 126 KAVEKPIEKATQQDVEIHVTSIAVVSLAEYPLPMQIEDLTFPSSVFKKQEEDIAKVDEKI 185 Query: 165 -------EGEE--------------------EGRATVNQDTRLDNRVIDLRTSTSQAVFR 197 EG++ + V+QDTRLDNR++DLRT T+ A+FR Sbjct: 186 AKFLKDNEGKDLTKRPLKDEYAKLLKEKASAQKYVKVSQDTRLDNRMLDLRTVTNIAIFR 245 Query: 198 LQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMC 257 +QS C LFRE L ++ FVEI TPK+I +SEGG+N+F V YF AYLAQSPQLYKQM Sbjct: 246 IQSACCGLFREFLTSQKFVEIHTPKLIGCSSEGGSNIFEVKYFDRKAYLAQSPQLYKQMA 305 Query: 258 ICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIFKGL 317 I DF KVF +GPVFRAE+SNT RHLTEF GLDIEM +YHE ++ + IF + Sbjct: 306 IMGDFRKVFEVGPVFRAENSNTRRHLTEFEGLDIEMEIVENYHECIDVMEKLFTFIFDEI 365 Query: 318 QERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLG 377 +RF E++ + KQ+P E + P LRL Y EA+ MLR +G +GD DD +TP E LG Sbjct: 366 PKRFPDELKVIRKQYPFEDLIY-RPFLRLTYKEAIEMLRASGETIGDYDDFTTPQEVKLG 424 Query: 378 HLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQL 437 L+K KY+TDFYILDK+P A+RPFYTMPD +P SNSYD+F+RG+EI SGAQRIHDP+ Sbjct: 425 ELIKAKYNTDFYILDKFPAAIRPFYTMPDIDDPNYSNSYDVFVRGQEITSGAQRIHDPEF 484 Query: 438 LTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPK 497 L +R + G+D +K YI+SFRFG+ PHAG GIGLER+TML+LG+ N+R+ ++FPRDP Sbjct: 485 LMKRCIEKGVDPATLKDYIESFRFGSWPHAGCGIGLERITMLYLGIPNIRKVTLFPRDPI 544 Query: 498 RLTP 501 RL P Sbjct: 545 RLNP 548 >6OD8-A nrPDB Length = 558 Score = 466 bits (1198), Expect = e-131, Method: Compositional matrix adjust. Identities = 262/536 (48%), Positives = 334/536 (62%), Gaps = 50/536 (9%) Query: 6 ASRKSQEKPREIMDAA--EDYAKERYGISSMIQSQEKPDRVLVRVRDLT-IQKADEVVWV 62 A+R ++EK R AA E Y K +G + M+QS R + V +L+ + D+ V + Sbjct: 33 AARLAEEKARADEKAALVEKY-KAVFGAAPMVQSTTYKSRTHIPVSELSRPELVDKTVLI 91 Query: 63 RARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRK 122 RARV T+R KGK F+VLR +VQA+ AV K+M+ F I ESIVDVE V K Sbjct: 92 RARVSTTRKKGKMAFMVLRDGSDSVQAMAAVEGDVPKEMIDFMGQIATESIVDVEATVCK 151 Query: 123 VNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPE-AEGEEEGRATVNQDTRLD 181 V Q I S + D+EL V+KI+ ++ + LP L+DA R E AEG A VN DTRL+ Sbjct: 152 VEQPITSTSHSDIELKVKKIHTVTESLRTLPFTLEDASRKESAEG-----AKVNLDTRLN 206 Query: 182 NRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFK 241 +R +DLRT S A+FRLQS +C FR+ LI+K F EI +PKII+A SEGGANVF + YF Sbjct: 207 SRWMDLRTLASGAIFRLQSRVCQYFRQFLIDKDFCEIHSPKIINAPSEGGANVFKLEYFN 266 Query: 242 NNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHE 301 AYLAQSPQLYKQM + D +VF +GPVFR+E+SNTHRHLTEFVGLD+EM + HY+E Sbjct: 267 RFAYLAQSPQLYKQMVLQGDVPRVFEVGPVFRSENSNTHRHLTEFVGLDVEMRIDEHYYE 326 Query: 302 VMEEIADTMVQIFKGLQERFQT---EIQTVNKQFPCEPFKF------------------L 340 V+ D +F + ER T E++ V +Q+P EP + + Sbjct: 327 VL----DVAESLFNYIFERLATHTKELKNVCQQYPFEPLVWKLTPERIKELGVGVISEGV 382 Query: 341 EPT--------------LRLEYCEALAMLREAGVE-MGDEDDLSTPNEKLLGHLVKEKYD 385 PT LR+ Y + +L E M DD++T NEKLLG LVKE+Y Sbjct: 383 VPTDKFQARVHNMDSRMLRINYMHCIELLNTVLDEKMAPTDDINTTNEKLLGKLVKERYG 442 Query: 386 TDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHH 445 TDF+I D++P + RPFYTM + + +NSYDMF+RGEEI SGAQRIHDP LL RA Sbjct: 443 TDFFISDRFPSSARPFYTMECKDDVRFTNSYDMFIRGEEISSGAQRIHDPDLLLARAKML 502 Query: 446 GIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501 +DL IK Y+DSFR GA PH G GIGLERV ML+LGL NVR S+FPRDP+R TP Sbjct: 503 NVDLTPIKEYVDSFRLGAWPHGGFGIGLERVVMLYLGLSNVRLASLFPRDPQRTTP 558 >1WYD-A nrPDB Length = 429 Score = 286 bits (732), Expect = 1e-77, Method: Compositional matrix adjust. Identities = 165/444 (37%), Positives = 251/444 (56%), Gaps = 32/444 (7%) Query: 58 EVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVE 117 EV+W VH R G + F++LR + Q +V A + + +ES++ V Sbjct: 18 EVIWA-GWVHLLRDLGGKKFIILRDKTGLGQVVVDKNSSA----FGISQELTQESVIQVR 72 Query: 118 GVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQD 177 G+V K + +ELH ++I ++S A+ LPL + G+ + D Sbjct: 73 GIV-----KADKRAPRGIELHAEEITLLSKAKAPLPLDVS------------GKVKADID 115 Query: 178 TRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTV 237 TRL RV+DLR QAV ++QS FRETL +GF+EI TPKII++A+EGGA +F V Sbjct: 116 TRLRERVLDLRRQEMQAVIKIQSLALKAFRETLYKEGFIEIFTPKIIASATEGGAQLFPV 175 Query: 238 SYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNY 297 YF A+LAQSPQLYK++ + E+VF + P +RAE+S+T HL EF+ +D+EMAF Sbjct: 176 IYFGKEAFLAQSPQLYKEL-MAGVVERVFEVAPAWRAEESDTPFHLAEFISMDVEMAFA- 233 Query: 298 HYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLRE 357 Y++VM+ + + I K ++E + E++ +N EP + P RL+Y EA+ +LR Sbjct: 234 DYNDVMQLLEKILHNIVKTIKEEGKEELKILN----YEPPEVKIPIKRLKYTEAIEILRS 289 Query: 358 AGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYD 417 G + DD+ TP ++L +KE D Y + +P RPFYT NP+ S S+D Sbjct: 290 KGYNIKFGDDIGTPELRILNEELKE----DLYFIVDWPSDARPFYTKSKSENPELSESFD 345 Query: 418 MFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVT 477 + + EI+SG+ R H ++L E G+ E + ++ F +G PPHAG G+GL R+ Sbjct: 346 LIYKFLEIVSGSTRNHKREVLEEALKKKGLKPESFEFFLKWFDYGMPPHAGFGMGLARLM 405 Query: 478 MLFLGLHNVRQTSMFPRDPKRLTP 501 ++ G+ +V++ FPRD KRLTP Sbjct: 406 VMLTGIQSVKEIVPFPRDKKRLTP 429 >3NEM-A nrPDB Length = 438 Score = 265 bits (678), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 162/456 (35%), Positives = 240/456 (52%), Gaps = 34/456 (7%) Query: 50 DLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANIN 109 +L QK WV + G FL +R + VQ + A ++ K + Sbjct: 13 ELNGQKVKVAGWV----WEVKDLGGIKFLWIRDRDGIVQ-ITAPKKKVDPELFKLIPKLR 67 Query: 110 KESIVDVEGVVRKVNQ-KIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEE 168 E +V VEGVV + K+G E+ +KI V++ AE LPL + Sbjct: 68 SEDVVAVEGVVNFTPKAKLG------FEILPEKIVVLNRAETPLPL------------DP 109 Query: 169 EGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAAS 228 G+ DTRLDNR +DLR A+F+++S + R+ GF+EI TPKII+ A+ Sbjct: 110 TGKVKAELDTRLDNRFMDLRRPEVMAIFKIRSSVFKAVRDFFHENGFIEIHTPKIIATAT 169 Query: 229 EGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVG 288 EGG +F + YF+ +A+LAQSPQLYKQ+ + + ++V+ I P+FRAE+ NT RHL E Sbjct: 170 EGGTELFPMKYFEEDAFLAQSPQLYKQIMMASGLDRVYEIAPIFRAEEHNTTRHLNEAWS 229 Query: 289 LDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTL---R 345 +D EMAF EVM + + ++E E+ +N F+ EP L R Sbjct: 230 IDSEMAFIEDEEEVMSFLERLVAHAINYVREHNAKELDILN-------FELEEPKLPFPR 282 Query: 346 LEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMP 405 + Y +AL +L + G E+ +D+ T E+LLG + E + Y L +YP +PFY M Sbjct: 283 VSYDKALEILGDLGKEIPWGEDIDTEGERLLGKYMMENENAPLYFLYQYPSEAKPFYIMK 342 Query: 406 DPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPP 465 P+ ++D+ RG EI SG QR H +L E+ G++ E + Y+ +FR+G PP Sbjct: 343 YDNKPEICRAFDLEYRGVEISSGGQREHRHDILVEQIKEKGLNPESFEFYLKAFRYGMPP 402 Query: 466 HAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501 H G G+G ER+ L L N+R+ +FPRD +RLTP Sbjct: 403 HGGFGLGAERLIKQMLDLPNIREVILFPRDRRRLTP 438 >1N9W-A nrPDB Length = 422 Score = 249 bits (637), Expect = 2e-66, Method: Compositional matrix adjust. Identities = 162/457 (35%), Positives = 242/457 (52%), Gaps = 38/457 (8%) Query: 46 VRVRDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFA 105 V VRDL EV + +H R G+ FL+LR + VQ + +K Sbjct: 3 VLVRDLKAHVGQEVE-LLGFLHWRRDLGRIQFLLLRDRSGVVQVVTG--------GLKLP 53 Query: 106 ANINKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAE 165 ES + V G+V + + G +E+ +++ V+S A P+++ Sbjct: 54 L---PESALRVRGLVVENAKAPGG-----LEVQAKEVEVLSPALEPTPVEIP-------- 97 Query: 166 GEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIIS 225 +EE RA N DT L+ R + LR ++A ++Q+ + FR L + F EI TPK++ Sbjct: 98 -KEEWRA--NPDTLLEYRYVTLRGEKARAPLKVQAALVRGFRRYLDRQDFTEIFTPKVVR 154 Query: 226 AASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTE 285 A +EGG+ +F V YF+ AYLAQSPQLYKQ+ + FE+V+ + PV+R E+ +T RHL E Sbjct: 155 AGAEGGSGLFGVDYFEKRAYLAQSPQLYKQIMVGV-FERVYEVAPVWRMEEHHTSRHLNE 213 Query: 286 FVGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLR 345 ++ LD+EM F ++M + ++ + EI+ + +P P + R Sbjct: 214 YLSLDVEMGFIADEEDLMRLEEALLAEMLEEALNTAGDEIRLLGATWPSFP----QDIPR 269 Query: 346 LEYCEALAMLREA-GVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTM 404 L + EA +L+E G +G DLS E+LLG KE++ +D+ + +YP +VRPFYT Sbjct: 270 LTHAEAKRILKEELGYPVGQ--DLSEEAERLLGEYAKERWGSDWLFVTRYPRSVRPFYTY 327 Query: 405 PDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAP 464 P+ + S+D+ RG EI SG QRIH + L E G+D E Y++ F++G P Sbjct: 328 PE--EDGTTRSFDLLFRGLEITSGGQRIHRYEELLESLKAKGMDPEAFHGYLEVFKYGMP 385 Query: 465 PHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501 PH G IG ER+T LGL NVR FPRD RLTP Sbjct: 386 PHGGFAIGAERLTQKLLGLPNVRYARAFPRDRHRLTP 422 >1X54-A nrPDB Length = 434 Score = 218 bits (555), Expect = 5e-57, Method: Compositional matrix adjust. Identities = 150/448 (33%), Positives = 236/448 (52%), Gaps = 50/448 (11%) Query: 66 VHTSRAKGKQCFLVLRQQQFNVQALVA---VGDHASKQMVKFAANINKESIVDVEGVVRK 122 V+T+ GK+ FL +R VQA+VA VG+ ++ A + +ES V VEG+V+ Sbjct: 25 VYTNMRVGKKIFLWIRDSTGIVQAVVAKNVVGEETFEK----AKKLGRESSVIVEGIVKA 80 Query: 123 VNQKIGSCTQQDVELHVQKIYVI-SLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRLD 181 + G E+HV+K+ VI +++E +P E + + LD Sbjct: 81 DERAPGGA-----EVHVEKLEVIQAVSEFPIP---------------ENPEQASPELLLD 120 Query: 182 NRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFK 241 R + +RT + A+ +++ + RE L+ G+ E+ P +++ A EGGA +F + YF Sbjct: 121 YRHLHIRTPKASAIMKVKETLIMAAREWLLKDGWHEVFPPILVTGAVEGGATLFKLKYFD 180 Query: 242 NNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFN--YHY 299 AYL+QS QLY + I EKV+S+ P FRAE S T RHLTEF L++E A+ + Sbjct: 181 KYAYLSQSAQLYLEAAIFG-LEKVWSLTPSFRAEKSRTRRHLTEFWHLELEAAWMDLWDI 239 Query: 300 HEVMEEIADTMVQ----IFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAML 355 +V EE+ MVQ + K E F+ ++ T+ P P R+ Y EA+ +L Sbjct: 240 MKVEEELVSYMVQRTLELRKKEIEMFRDDLTTLKNTEP--------PFPRISYDEAIDIL 291 Query: 356 REAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNS 415 + GV + DDL E++L E++D F++ YP ++ FY DP +P++ + Sbjct: 292 QSKGVNVEWGDDLGADEERVL----TEEFDRPFFVYG-YPKHIKAFYMKEDPNDPRKVLA 346 Query: 416 YDMFM-RG-EEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGL 473 DM G EI+ G+QR D L R L G+D + + Y+D R+G+ PH+G G+G+ Sbjct: 347 SDMLAPEGYGEIIGGSQREDDYDKLLNRILEEGMDPKDYEWYLDLRRYGSVPHSGFGLGV 406 Query: 474 ERVTMLFLGLHNVRQTSMFPRDPKRLTP 501 ER+ L L ++R ++FPR P RL P Sbjct: 407 ERLVAWVLKLDHIRWAALFPRTPARLYP 434 >5ZG8-A nrPDB Length = 438 Score = 176 bits (447), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 143/468 (30%), Positives = 224/468 (47%), Gaps = 51/468 (10%) Query: 50 DLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANIN 109 D + D+ V +R ++ R+KGK FL+LR +QA V G+ + + + A ++ Sbjct: 6 DEIARHVDQEVELRGWLYQRRSKGKIHFLILRDGTGFLQATVVQGE-VPEAVFREADHLP 64 Query: 110 KESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEE 169 +E+ + V G VR+ + G EL V+ + V+S + P+ Sbjct: 65 QETALRVWGRVREDRRAPGG-----FELAVRDLQVVSRPQGEYPI--------------- 104 Query: 170 GRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASE 229 G D +D+R + LR AV R++ + E +GF+ P + +A E Sbjct: 105 GPKEHGIDFLMDHRHLWLRHRRPFAVMRIRDELERAIHEFFGERGFLRFDAPILTPSAVE 164 Query: 230 GGANVFTVSYFKN-NAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVG 288 G +F V F AYL+QS QLY + A F KV++ GP FRAE S T RHL EF Sbjct: 165 GTTELFEVELFDGEKAYLSQSGQLYAEAGALA-FAKVYTFGPTFRAERSKTRRHLLEFWM 223 Query: 289 LDIEMAFNYHYHE--VMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTL-- 344 ++ E+AF H + EE+ +V + ER E++ + + +P K LEP Sbjct: 224 VEPEVAFMTHEENMALQEELVSFLV---ARVLERRSRELEMLGR----DP-KALEPAAEG 275 Query: 345 ---RLEYCEALAMLREAGVE------MGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYP 395 RL Y EA+A++ E + +D P+E L ++D ++ ++YP Sbjct: 276 HYPRLTYKEAVALVNRIAQEDPEVPPLPYGEDFGAPHEAAL----SRRFDRPVFV-ERYP 330 Query: 396 LAVRPFYTMPDPRNPKQSNSYDMFMRGE--EILSGAQRIHDPQLLTERALHHGIDLEKIK 453 ++ FY PDP +P+ + D+ EI+ G+QRIHD +LL + G+ E Sbjct: 331 ARIKAFYMEPDPEDPELVLNDDLLAPEGYGEIIGGSQRIHDLELLRRKIQEFGLPEEVYD 390 Query: 454 AYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501 Y+D RFG+ PH+G G+GLER GL +VR+ FPR R+ P Sbjct: 391 WYLDLRRFGSVPHSGFGLGLERTVAWICGLAHVREAIPFPRMYTRMRP 438 >2XGT-A nrPDB Length = 435 Score = 154 bits (388), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 130/468 (27%), Positives = 221/468 (47%), Gaps = 45/468 (9%) Query: 46 VRVRDLTIQKADEVVWVRARVHTSRAKGKQC-FLVLRQQQFNVQALVAVGDHASKQMVKF 104 V++RDL ++ +E V ++ +H R +GK F +LR +Q L+ D + Sbjct: 1 VKIRDL-VKHRNERVCIKGWIHRMRRQGKSLMFFILRDGTGFLQVLLM--DKLCQTYD-- 55 Query: 105 AANINKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEA 164 A +N E V++ G +++V + G EL +I A P +D+ + EA Sbjct: 56 ALTVNTECTVEIYGAIKEVPE--GKEAPNGHELIADFWKIIGNAPPG---GIDNVLNEEA 110 Query: 165 EGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKII 224 + D LDNR + +R + A+ RL++ RE N G+VE+ P ++ Sbjct: 111 ----------SVDKMLDNRHLVIRGENAAALLRLRAAATRAMREHFYNAGYVEVAPPTLV 160 Query: 225 SAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLT 284 EGG+ +F + YF ++L QS QLY + CI VF I +RAE S T RHL Sbjct: 161 QTQVEGGSTLFNLDYFGEQSFLTQSSQLYLETCI-PTLGDVFCIAQSYRAEKSRTRRHLA 219 Query: 285 EFVGLDIEMAFNYHYHEVMEEIADTMVQIFKGL--QERFQTEIQTVNKQF--PCEPFKFL 340 E+ ++ E F ++ME+I + + L E + ++ +N +F P PF Sbjct: 220 EYAHVEAECPF-ITLDDLMEKIEELVCDTVDRLLADEEAKKLLEHINPKFQPPERPF--- 275 Query: 341 EPTLRLEYCEALAMLREAGV--EMGDE----DDLSTPNEKLLGHLVKEKYDTDFYILDKY 394 LR+EY +A+ L+E V E G+ +D++ E+ + + + +L+++ Sbjct: 276 ---LRMEYKDAIKWLQEHNVENEFGNTFTYGEDIAEAAERFMTDTINKP-----ILLNRF 327 Query: 395 PLAVRPFYTMPDPRNPKQSNSYDMFMRG-EEILSGAQRIHDPQLLTERALHHGIDLEKIK 453 P ++ FY D ++ + S D+ M G EI+ G+ RI L++ + ID + Sbjct: 328 PSEIKAFYMQRDAQDNTLTESVDLLMPGVGEIVGGSMRIWKFDELSKAFKNVEIDPKPYY 387 Query: 454 AYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501 Y+D +G PH G G+GLER +++R ++PR R P Sbjct: 388 WYLDQRLYGTCPHGGYGLGLERFICWLTNTNHIRDVCLYPRFVGRCVP 435 >5XIX-A nrPDB Length = 472 Score = 153 bits (387), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 124/453 (27%), Positives = 203/453 (44%), Gaps = 43/453 (9%) Query: 60 VWVRARVHTSRAKGKQC-FLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEG 118 V V VH R +GK FLVLR +Q ++A D + ++ ES V V G Sbjct: 52 VKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVLA--DELCQ--CYNGVLLSTESSVAVYG 107 Query: 119 VVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDT 178 ++ + G EL +I LA P + + D Sbjct: 108 MLNLTPK--GKQAPGGHELSCDFWELIGLA-------------PAGGADNLINEESDVDV 152 Query: 179 RLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVS 238 +L+NR + +R + + +S + FR+ ++G+ E+ P ++ EGGA +F + Sbjct: 153 QLNNRHMMIRGENMSKILKARSMVTRCFRDHFFDRGYYEVTPPTLVQTQVEGGATLFKLD 212 Query: 239 YFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIE---MAF 295 YF A+L QS QLY + C+ A VF I +RAE S T RHL E+ ++ E + F Sbjct: 213 YFGEEAFLTQSSQLYLETCLPA-LGDVFCIAQSYRAEQSRTRRHLAEYTHVEAECPFLTF 271 Query: 296 NYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAML 355 + + + + + D + +I K E+ N Q P PFK R+ Y +A+ L Sbjct: 272 DDLLNRLEDLVCDVVDRILKSPAGSIVHELNP-NFQPPKRPFK------RMNYSDAIVWL 324 Query: 356 REAGVEMGD------EDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRN 409 +E V+ D +D+ E+L+ + E +L ++P+ ++ FY P + Sbjct: 325 KEHDVKKEDGTFYEFGEDIPEAPERLMTDTINEP-----ILLCRFPVEIKSFYMQRCPED 379 Query: 410 PKQSNSYDMFMRG-EEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAG 468 + + S D+ M EI+ G+ RI D + + GID Y D ++G PH G Sbjct: 380 SRLTESVDVLMPNVGEIVGGSMRIFDSEEILAGYKREGIDPTPYYWYTDQRKYGTCPHGG 439 Query: 469 GGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501 G+GLER L +++R ++PR +R TP Sbjct: 440 YGLGLERFLTWILNRYHIRDVCLYPRFVQRCTP 472 >3M4P-A nrPDB Length = 456 Score = 149 bits (375), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 120/465 (25%), Positives = 217/465 (46%), Gaps = 33/465 (7%) Query: 44 VLVRVRDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVK 103 ++ +RD + V + H +A+ F+ LR Q ++ + + VK Sbjct: 18 IVCNIRDAAGLEGKLVTFKGWAYHIRKARKTLIFVELRDGSGYCQCVIFGKELCEPEKVK 77 Query: 104 FAANINKESIVDVEGVVRKVNQKIGSCTQQDV---ELHVQKIYVISLAEPRLPLQLDDAV 160 + +E +++ G + K D+ E+ V + VI + P+ L++ + Sbjct: 78 L---LTRECSLEITGRLNAYAGKNHPPEIADILNLEMQVTEWKVIGES----PIDLENII 130 Query: 161 RPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQT 220 ++ ++ Q ++ NR I +R+ +Q V +L+S I FR+ + F EIQ Sbjct: 131 NKDS--------SIPQ--KMQNRHIVIRSEHTQQVLQLRSEIQWYFRKYYHDNHFTEIQP 180 Query: 221 PKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTH 280 P I+ EGG+ +F + YF AYL QS QLY + I A K F + +RAE S T Sbjct: 181 PTIVKTQCEGGSTLFKLQYFNEPAYLTQSSQLYLESVI-ASLGKSFCMLSSYRAEQSRTV 239 Query: 281 RHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNK--QFPCEPFK 338 RHL E++ L+ E+ F + +++ + D + + + +I+ +N + P PFK Sbjct: 240 RHLAEYLHLEAELPF-ISFEDLLNHLEDLVCTVIDNVMAVHGDKIRKMNPHLKLPTRPFK 298 Query: 339 FLEPTLRLEYCEALAML-REAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLA 397 + ++YC +L ++ E G +D+S E+ + E F I +P Sbjct: 299 RMTYADAIKYCNDHGILNKDKPFEYG--EDISEKPER---QMTDEIGCPIFMI--HFPSK 351 Query: 398 VRPFYTMPDPRNPKQSNSYDMFMRG-EEILSGAQRIHDPQLLTERALHHGIDLEKIKAYI 456 ++ FY P +P + S D+ M G EI+ G+ RI + L +G++ + Y Sbjct: 352 MKAFYMSKVPGHPDLTESVDLLMPGVGEIVGGSMRIWNYDELMGAYKANGLNPDPYYWYT 411 Query: 457 DSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501 ++G+ PH G G+G+ER+ M LG ++R+ ++PR +R P Sbjct: 412 QQRKYGSCPHGGYGLGVERLVMWLLGEDHIRKVCLYPRYLERCEP 456 >1BBU-A nrPDB Length = 504 Score = 106 bits (264), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 114/466 (24%), Positives = 199/466 (42%), Gaps = 66/466 (14%) Query: 60 VWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGV 119 V V R+ T R GK F+ L+ +Q VA D + K + D+ G Sbjct: 67 VAVAGRMMTRRIMGKASFVTLQDVGGRIQLYVARDDLPEG---VYNEQFKKWDLGDILGA 123 Query: 120 VRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTR 179 K+ ++ +H ++ +++ A LP ++ +Q+ R Sbjct: 124 ----KGKLFKTKTGELSIHCTELRLLTKALRPLP--------------DKFHGLQDQEAR 165 Query: 180 LDNRVIDLRTST-SQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVS 238 R +DL ++ S+ F+++S I R+ ++N+GF+E++TP + A F Sbjct: 166 YRQRYLDLISNDESRNTFKVRSQILSGIRQFMVNRGFMEVETPMMQVIPGGAAARPFITH 225 Query: 239 Y--FKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFN 296 + + YL +P+LY + + FE+VF I FR E + RH EF +++ MA+ Sbjct: 226 HNALDLDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGISV-RHNPEFTMMELYMAYA 284 Query: 297 YHYH--EVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAM 354 + E+ E + T+ Q G +TE+ + F +P +L EA+ Sbjct: 285 DYKDLIELTESLFRTLAQDILG-----KTEVT-----YGDVTLDFGKPFEKLTMREAIKK 334 Query: 355 LREAGVEMGDEDDLSTPN----------EKL--LGHLVKEKYD-------TDFYILDKYP 395 R +M D D+ + EK LG +V E ++ + +YP Sbjct: 335 YRPE-TDMADLDNFDSAKAIAESIGIHVEKSWGLGRIVTEIFEEVAEAHLIQPTFITEYP 393 Query: 396 LAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQ-----LLTERALHHGIDLE 450 V P D NP+ ++ ++ F+ G EI +G ++D + L + A D E Sbjct: 394 AEVSPLARRNDV-NPEITDRFEFFIGGREIGNGFSELNDAEDQAQRFLDQVAAKDAGDDE 452 Query: 451 KI---KAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFP 493 + + Y+ + G PP AG GIG++R+ MLF H +R +FP Sbjct: 453 AMFYDEDYVTALEHGLPPTAGLGIGIDRMVMLFTNSHTIRDVILFP 498 >1LYL-A nrPDB Length = 504 Score = 106 bits (264), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 113/464 (24%), Positives = 194/464 (41%), Gaps = 62/464 (13%) Query: 60 VWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGV 119 V V R+ T R GK F+ L+ +Q VA S + K + D+ G Sbjct: 67 VSVAGRMMTRRIMGKASFVTLQDVGGRIQLYVA---RDSLPEGVYNDQFKKWDLGDIIGA 123 Query: 120 VRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTR 179 + ++ +H ++ +++ A LP ++ +Q+ R Sbjct: 124 ----RGTLFKTQTGELSIHCTELRLLTKALRPLP--------------DKFHGLQDQEVR 165 Query: 180 LDNRVIDL-RTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVS 238 R +DL S+ F ++S I R+ ++ +GF+E++TP + A F Sbjct: 166 YRQRYLDLIANDKSRQTFVVRSKILAAIRQFMVARGFMEVETPMMQVIPGGASARPFITH 225 Query: 239 Y--FKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFN 296 + + YL +P+LY + + FE+VF I FR E + RH EF +++ MA+ Sbjct: 226 HNALDLDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGISV-RHNPEFTMMELYMAYA 284 Query: 297 YHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLR 356 YH+++E +F+ L Q + T + F F +P +L EA+ R Sbjct: 285 -DYHDLIE----LTESLFRTLA---QEVLGTTKVTYGEHVFDFGKPFEKLTMREAIKKYR 336 Query: 357 EAGVEMGDEDD------------LSTPNEKLLGHLVKEKYD-------TDFYILDKYPLA 397 +M D D+ ++ LG +V E +D + +YP Sbjct: 337 PE-TDMADLDNFDAAKALAESIGITVEKSWGLGRIVTEIFDEVAEAHLIQPTFITEYPAE 395 Query: 398 VRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTER------ALHHGIDLEK 451 V P D NP+ ++ ++ F+ G EI +G ++D + ER A G D Sbjct: 396 VSPLARRNDV-NPEITDRFEFFIGGREIGNGFSELNDAEDQAERFQEQVNAKAAGDDEAM 454 Query: 452 I--KAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFP 493 + Y+ + +G PP AG GIG++R+ MLF H +R +FP Sbjct: 455 FYDEDYVTALEYGLPPTAGLGIGIDRMIMLFTNSHTIRDVILFP 498 >6AQG-A nrPDB Length = 506 Score = 102 bits (255), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 113/471 (23%), Positives = 213/471 (45%), Gaps = 55/471 (11%) Query: 50 DLTIQKADE-VVWVRARVHTSRAKGKQCFLVLRQQQFN-VQALVAVGDHASKQMVKFAAN 107 DL A E +V V RV +R GK CF L+ +QA++++ + + + ++ A+ Sbjct: 57 DLPTDSATEDIVGVAGRVVFARNTGKLCFATLQDGDGTQLQAMISLDEVGRESLDRWKAD 116 Query: 108 INKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEP-RLPLQLDDAVRPEAEG 166 ++ +V V G V ++ + G EL V LA+ R+ + A+RP Sbjct: 117 VDIGDVVYVHGTV--ISSRRG-------ELSV-------LADSWRMAAK---ALRPLPVA 157 Query: 167 EEEGRATVNQDTRLDNRVIDLRTS-TSQAVFRLQSGICHLFRETLINKGFVEIQTPKIIS 225 +E +++++R+ R +DL ++ V R + + R L +GF+E++TP + + Sbjct: 158 HKE----MSEESRVRQRYVDLIVRPQAREVARQRIAVIRAVRNALERRGFLEVETPMLQT 213 Query: 226 AASEGGANVFTV--SYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHL 283 A A F + + YL +P+L+ + CI F++VF + VFR E S++ H Sbjct: 214 LAGGAAARPFVTHSNALDIDLYLRIAPELFLKRCIVGGFDRVFELNRVFRNEGSDST-HS 272 Query: 284 TEFVGLDIEMAFNYH------YHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPF 337 EF L+ + + E+++E+AD + + L + + E + Sbjct: 273 PEFSMLETYQTYGTYDDSALITRELIQEVADEAIGT-RQLSMPDGSVYDIDGEWATMEMY 331 Query: 338 KFLEPTLRLEYC--EALAMLREAGVEMGDEDDLSTPN-----EKLLGHLVKEKYDTDFYI 390 L L + +A LR+ + E D S E+L H V K ++ Sbjct: 332 SSLSEALGEQITPETTVARLRDIASGLDVEIDNSVFGHGKLVEELWEHAVGNKLTAPTFV 391 Query: 391 LDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTER--------A 442 D +P+ P T P + +D+++RG E+ +G ++DP + +R A Sbjct: 392 KD-FPVETTPL-TRQHRSIPGVTEKWDLYVRGVELATGYSELNDPVVQRDRFADQARAAA 449 Query: 443 LHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFP 493 ++ + ++ + +G PP G G+G++R+ M GL ++R+T +FP Sbjct: 450 AGDDEAMQLDEDFLTALEYGMPPCTGTGMGIDRLLMCLTGL-SIRETVLFP 499 >6AQH-A nrPDB Length = 508 Score = 102 bits (254), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 113/481 (23%), Positives = 200/481 (41%), Gaps = 85/481 (17%) Query: 55 KADEVVWVRARVHTSRAKGKQCFLVLRQQQ-FNVQALVAVGDHASKQMVKFAANINKESI 113 + E+V V RV +R GK CF L++ +QA++++ + + + + ++ I Sbjct: 66 RTGEIVGVTGRVVFARNSGKLCFATLQEGDGTQLQAMISLAEVGQEALDNWKTYVDIGDI 125 Query: 114 VDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRAT 173 V V G V T + EL V A+ PL P A E Sbjct: 126 VFVHGEV---------ITSKRGELSVLADSWQMAAKALRPL-------PVAHKE------ 163 Query: 174 VNQDTRLDNRVIDLRT-STSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGA 232 +++++R+ R +DL ++ V R + + R L +GF+E++TP + + A A Sbjct: 164 MSEESRVRQRYVDLIVRDQARKVARQRIAVMRAIRSALERRGFLEVETPMLQTLAGGAAA 223 Query: 233 NVFTV--SYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLD 290 F + YL +P+L+ + C+ FE+VF + VFR E +++ H EFV L+ Sbjct: 224 RPFVTHSNALDTELYLRIAPELFLKRCLVGGFERVFELNRVFRNEGADST-HSPEFVMLE 282 Query: 291 IEMAFNYH------YHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTL 344 A+ + E+++E+AD + +Q P + Sbjct: 283 TYQAYGTYDDSAVVTRELIQEVADEAIG----------------TRQVPLPDGTVYDLDG 326 Query: 345 RLEYCEALAMLREAGVEMGDEDDLSTPNEKLL------------------GHLVKEKYDT 386 E + L EA +G+E TP E L G LV+E ++ Sbjct: 327 EWESIQMYPSLSEA---LGEEITPDTPAETLWAIADRLGLDIPRDRGYGHGKLVEELWEH 383 Query: 387 DFYILDKYPLAVR--PFYTMPDPRN----PKQSNSYDMFMRGEEILSGAQRIHDPQLLTE 440 P V+ P T P R+ P + +D+++R E+ +G + DP + E Sbjct: 384 TVGAKLWAPTFVKDFPVETTPLTRSHRSIPGVTEKWDLYVRRIELATGYSELTDPIIQRE 443 Query: 441 R--------ALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMF 492 R A + + ++ + +G PP G G+G++R+ M GL ++R+T +F Sbjct: 444 RFEAQARAAAAGDDEAMALDEDFLAALEYGMPPSTGTGMGIDRLMMTLTGL-SIRETVLF 502 Query: 493 P 493 P Sbjct: 503 P 503 >3A74-A nrPDB Length = 493 Score = 90.5 bits (223), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 112/466 (24%), Positives = 191/466 (40%), Gaps = 66/466 (14%) Query: 60 VWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGV 119 V V R+ T R GK F ++ +Q V D +Q F + + IV V G Sbjct: 59 VAVAGRIMTKRGMGKAGFAHIQDVTGQIQIYVRQDDVGEQQYELFKIS-DLGDIVGVRGT 117 Query: 120 VRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTR 179 + K K+G + I ++ L A+RP E + G + Q R Sbjct: 118 MFKT--KVGELS-------------IKVSSYEF---LTKALRPLPE-KYHGLKDIEQ--R 156 Query: 180 LDNRVIDL-RTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVS 238 R +DL S+ F +S I R L + G++E++TP + + A A F Sbjct: 157 YRQRYLDLIMNPESKKTFITRSLIIQSMRRYLDSHGYLEVETPMMHAVAGGAAARPFITH 216 Query: 239 Y--FKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFN 296 + Y+ + +L+ + I EKV+ IG VFR E +T RH EF L++ Sbjct: 217 HNALDMTLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGIST-RHNPEFTMLEL----- 270 Query: 297 YHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLR-LEYCEALA-- 353 +E + D M ++ + L TE+ K E L P R L +A+ Sbjct: 271 ---YEAYADFRDIM-KLTENLIAHIATEVLGTTKIQYGEHLVDLTPEWRRLHMVDAIKEY 326 Query: 354 --------MLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDK---------YPL 396 M E E+ E + GH+V E ++ + DK +P+ Sbjct: 327 VGVDFWRQMSDEEARELAKEHGVEVAPHMTFGHIVNEFFEQK--VEDKLIQPTFIYGHPV 384 Query: 397 AVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDP--------QLLTERALHHGID 448 + P +P +P+ ++ +++F+ G E + ++DP + L ER + Sbjct: 385 EISPL-AKKNPDDPRFTDRFELFIVGREHANAFTELNDPIDQRQRFEEQLKEREQGNDEA 443 Query: 449 LEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPR 494 E + ++++ +G PP G GIG++R+ ML ++R +FP+ Sbjct: 444 HEMDEDFLEALEYGMPPTGGLGIGVDRLVMLLTNSPSIRDVLLFPQ 489 >5W25-A nrPDB Length = 616 Score = 86.3 bits (212), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 81/290 (27%), Positives = 120/290 (41%), Gaps = 27/290 (9%) Query: 61 WVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVV 120 WV R R G F+ LR Q V D +++ A + E V V GVV Sbjct: 46 WVARR----RDHGGVIFIDLRDASGIAQ--VVFRDPQDTEVLAQAHRLRAEFCVSVAGVV 99 Query: 121 --RKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDT 178 R ++E++ + V+ P LP QLD E GEE Sbjct: 100 EIRPEGNANPEIATGEIEVNATSLTVLGECAP-LPFQLD-----EPAGEE---------L 144 Query: 179 RLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVS 238 RL R +DLR A RL+S + R L FVEI+TP I + EG + + Sbjct: 145 RLKYRYLDLRRDDPAAAIRLRSRVNAAARAVLARHDFVEIETPTITRSTPEGARDFLVPA 204 Query: 239 YFKNNAY--LAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFN 296 ++ L QSPQL+KQ+ + A E+ + I +R ED R EF LD+EM+F Sbjct: 205 RLHPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQ-PEFTQLDMEMSF- 262 Query: 297 YHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRL 346 +++ + + +++ + R T I + F +P LR Sbjct: 263 VDAEDIIAISEEVLTELWALIGYRIPTPIPRIGYAEAMRRFGTDKPDLRF 312 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 30/93 (32%), Positives = 47/93 (50%), Gaps = 4/93 (4%) Query: 413 SNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDL----EKIKAYIDSFRFGAPPHAG 468 +++YD+ G EI G+ RIH + G+D EK +++F FGAPPH G Sbjct: 496 ADAYDIVCNGHEIGGGSVRIHRRDIQERVFAVMGLDKAEAEEKFGFLLEAFMFGAPPHGG 555 Query: 469 GGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501 G +R T L G+ ++R+ FP+ + P Sbjct: 556 IAFGWDRTTALLAGMDSIREVIAFPKTGGGVDP 588 >5ELO-A nrPDB Length = 535 Score = 85.5 bits (210), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 78/358 (21%), Positives = 152/358 (42%), Gaps = 49/358 (13%) Query: 175 NQDTRLDNRVIDLRTST-SQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGAN 233 +Q+ R R +DL + S+ VF+L+S R GF+E++TP + A Sbjct: 170 DQEVRYRQRYLDLMLNEESRKVFKLRSRAIKYIRNYFDRLGFLEVETPMLNMIYGGAAAR 229 Query: 234 VFTVSY--FKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDI 291 F + + Y+ +P+LY + I +KV+ IG FR E + H EF ++ Sbjct: 230 PFITYHNELETQLYMRIAPELYLKQLIVGGLDKVYEIGKNFRNEGIDL-THNPEFTAMEF 288 Query: 292 EMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEA 351 MA+ Y+++M+ + + + + + + C F P R + E Sbjct: 289 YMAYA-DYYDLMDLTEELISGLVLEIHGSLKIPYHPDGPEGKCIEIDFTTPWKRFSFVEE 347 Query: 352 LAMLREAG------------------VEMGDEDDLSTPN--------EKLLGHLVKEKYD 385 + E+G VEM ++ ++ P+ +KL GH V+ K Sbjct: 348 I----ESGLGEKLKRPLDSQENIDFMVEMCEKHEIELPHPRTAAKLLDKLAGHFVETKCT 403 Query: 386 TDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHH 445 +I+D +P + P + P+ + +++F+ G+E+ + +++P L +R Sbjct: 404 NPSFIID-HPQTMSPLAKWHREK-PEMTERFELFVLGKELCNAYTELNEP--LQQRKFFE 459 Query: 446 -------GIDLEKI---KAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFP 493 D+E + + + G PP G G+G++R+ M +N+++ +FP Sbjct: 460 QQADAKASGDVEACPIDETFCLALEHGLPPTGGWGLGIDRLIMFLADKNNIKEVILFP 517 >6ILH-A nrPDB Length = 521 Score = 84.7 bits (208), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 109/477 (22%), Positives = 195/477 (40%), Gaps = 66/477 (13%) Query: 56 ADEVVWVRARVHTSRAKG-KQCFLVLRQQQFNVQALVAVGDHASKQ-MVKFAANINKESI 113 D + V R+H RA G K F LR + +Q + ++ S++ + + + I Sbjct: 54 TDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDI 113 Query: 114 VDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRAT 173 + V+G K + S ++ L ++++ P L L D Sbjct: 114 IGVQGNPGKTKKGELSIIPYEITLLSPCLHML----PHLHFGLKD--------------- 154 Query: 174 VNQDTRLDNRVIDL-RTSTSQAVFRLQSGICHLFRETLINKGFVEIQTP--KIISAASEG 230 ++TR R +DL + F ++S I R L GF+EI+TP II + Sbjct: 155 --KETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVA 212 Query: 231 GANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLD 290 + + N Y+ +P+LY +M + ++V+ IG FR E + H EF + Sbjct: 213 KPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDL-THNPEFTTCE 271 Query: 291 IEMAF-NYHYH-EVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEY 348 MA+ +YH H E+ E++ MV+ G ++ + F P R+ Sbjct: 272 FYMAYADYHDHMEITEKMVSGMVKHITG---SYKVTYHPDGPEGQAYDVDFTPPFRRINM 328 Query: 349 CE----ALAM-LREAGVEMGDE-----DDLSTPN--------------EKLLGHLVKEKY 384 E AL M L E + +E DD+ +KL+G ++ Sbjct: 329 VEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTC 388 Query: 385 DTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDP----QLLTE 440 +I D +P + P + + +++F+ +EI + ++DP QL E Sbjct: 389 INPTFICD-HPQIMSPLAKWHRSKE-GLTERFELFVMKKEICNAYTELNDPMRQRQLFEE 446 Query: 441 RALHHGI-DLEKI---KAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFP 493 +A D E + + + + +G PP AG G+G++RV M +N+++ +FP Sbjct: 447 QAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 503 >6CHD-A nrPDB Length = 597 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 109/476 (22%), Positives = 196/476 (41%), Gaps = 64/476 (13%) Query: 56 ADEVVWVRARVHTSRAKG-KQCFLVLRQQQFNVQALVAVGDHASKQ-MVKFAANINKESI 113 D + V R+H RA G K F LR + +Q + ++ S++ + + + I Sbjct: 122 TDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDI 181 Query: 114 VDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRAT 173 + V+G K + S ++ L ++++ P L L D Sbjct: 182 IGVQGNPGKTKKGELSIIPYEITLLSPCLHML----PHLHFGLKD--------------- 222 Query: 174 VNQDTRLDNRVIDLRTST-SQAVFRLQSGICHLFRETLINKGFVEIQTP--KIISAASEG 230 ++TR R +DL + + F ++S I R L GF+EI+TP II + Sbjct: 223 --KETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVA 280 Query: 231 GANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLD 290 + + N Y+ +P+LY +M + ++V+ IG FR E + H EF + Sbjct: 281 KPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDL-THNPEFTTCE 339 Query: 291 IEMAFNYHYHEVMEEIADTMVQ-IFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYC 349 MA+ YH++ME I + MV + K + ++ + F P R+ Sbjct: 340 FYMAYA-DYHDLME-ITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINMV 397 Query: 350 E----ALAM-LREAGVEMGDE-----DDLSTPN--------------EKLLGHLVKEKYD 385 E AL M L E + +E DD+ +KL+G ++ Sbjct: 398 EELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTCI 457 Query: 386 TDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDP----QLLTER 441 +I D +P + P + + +++F+ +EI + ++DP QL E+ Sbjct: 458 NPTFICD-HPQIMSPLAKWHRSKE-GLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQ 515 Query: 442 ALHHGI-DLEKI---KAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFP 493 A D E + + + + +G PP AG G+G++RV M +N+++ +FP Sbjct: 516 AKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 >4RMF-A nrPDB Length = 609 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 72/244 (29%), Positives = 106/244 (43%), Gaps = 25/244 (10%) Query: 56 ADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVD 115 A + V + V R G F+ LR Q + GD ++ A + E V Sbjct: 15 AGQTVTLAGWVARRRDHGGVIFIDLRDASGVSQVVFREGD-----VLAAAHRLRAEFCVA 69 Query: 116 VEGVV--RKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRAT 173 V GVV R + +E++ ++ V+ + P LP QLD E GEE Sbjct: 70 VTGVVEVRPEGNENPEIPTGQIEVNATELTVLGESAP-LPFQLD-----EQAGEE----- 118 Query: 174 VNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGAN 233 RL R +DLR RL+S + R L FVEI+TP + + EG + Sbjct: 119 ----ARLKYRYLDLRREGPGNALRLRSKVNAAARSVLAEHDFVEIETPTLTRSTPEGARD 174 Query: 234 VFTVSYFKNNAY--LAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDI 291 + + ++ L QSPQL+KQ+ + A E+ + I +R ED R EF LD+ Sbjct: 175 FLVPARLQPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQ-PEFTQLDM 233 Query: 292 EMAF 295 EM+F Sbjct: 234 EMSF 237 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 35/100 (35%), Positives = 51/100 (51%), Gaps = 5/100 (5%) Query: 406 DPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGID----LEKIKAYIDSFRF 461 DP N S++YD+ G EI G+ RIH + GID EK +D+F + Sbjct: 465 DPGN-ALSDAYDIVCNGNEIGGGSIRIHRRDIQERVFAMMGIDHDEAQEKFGFLLDAFSY 523 Query: 462 GAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501 GAPPH G G +R+T L G+ ++R+ FP+ + P Sbjct: 524 GAPPHGGIAFGWDRITALLAGVDSIREVIAFPKSGGGVDP 563 >4YCV-A nrPDB Length = 516 Score = 82.0 bits (201), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 104/479 (21%), Positives = 194/479 (40%), Gaps = 73/479 (15%) Query: 57 DEVVWVRARVHTSRAKGKQCF---LVLRQQQFNVQALVAVGDHASKQMVKFAANINKESI 113 D ++ + R+ A G++ LV ++ V A + +H + I + I Sbjct: 55 DTILNITGRIMRVSASGQKLRFFDLVGDGEKIQVLANYSFHNHEKGNFAECYDKIRRGDI 114 Query: 114 VDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRAT 173 V + G G + ++ + ++ ++S LP++ Sbjct: 115 VGIVGFP-------GKSKKGELSIFPKETILLSACLHMLPMKY---------------GL 152 Query: 174 VNQDTRLDNRVIDLRTS-TSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGA 232 + + R R +DL + +S+ F ++ I + R L +GF E++TP + A GGA Sbjct: 153 KDTEIRYRQRYLDLLINESSRHTFVTRTKIINFLRNFLNERGFFEVETPMMNLIA--GGA 210 Query: 233 NVFTVSYFKNNA----YLAQSPQLYKQMCICADFEKVFSIGPVFRAED-SNTHRHLTEFV 287 N N+ YL + +L +M I +KV+ IG VFR E NTH EF Sbjct: 211 NARPFITHHNDLDLDLYLRIATELPLKMLIVGGIDKVYEIGKVFRNEGIDNTHN--PEFT 268 Query: 288 GLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFP-CEPFK--FLEPTL 344 + A+ Y+++++ D Q+ L F T + NK P +P + F P Sbjct: 269 SCEFYWAYA-DYNDLIKWSEDFFSQLVYHL---FGTYKISYNKDGPENQPIEIDFTPPYP 324 Query: 345 RLEYCEALAMLR--------------EAGVEMGDEDDLSTPN--------EKLLGHLVKE 382 ++ E + + E + + E + PN ++L H ++ Sbjct: 325 KVSIVEEIEKVTNTILEQPFDSNETIEKMINIIKEHKIELPNPPTAAKLLDQLASHFIEN 384 Query: 383 KYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERA 442 KY+ + + ++P + P + P + +MF+ G+E+L+ ++DP E Sbjct: 385 KYNDKPFFIVEHPQIMSPLAKYHRTK-PGLTERLEMFICGKEVLNAYTELNDPFKQKECF 443 Query: 443 LHHGIDLEK--------IKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFP 493 D EK A+ S +G PP G G+G++R+TM ++++ +FP Sbjct: 444 KLQQKDREKGDTEAAQLDSAFCTSLEYGLPPTGGLGLGIDRITMFLTNKNSIKDVILFP 502 >4EX5-A nrPDB Length = 529 Score = 81.6 bits (200), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 103/471 (21%), Positives = 184/471 (39%), Gaps = 73/471 (15%) Query: 60 VWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGV 119 V + R+ R GK F ++ +Q V D ++ F + IV GV Sbjct: 89 VAIAGRMMLKRVMGKASFATVQDGSGQIQFFVTPADVGAETYDAFK-KWDLGDIVAARGV 147 Query: 120 VRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTR 179 + + N+ EL V+ + LA+ PL ++ +Q+TR Sbjct: 148 LFRTNKG---------ELSVKCTQLRLLAKALRPL------------PDKFHGLADQETR 186 Query: 180 LDNRVIDL-RTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVS 238 R +DL T ++ FR ++ R+ + + F+E++TP + A F Sbjct: 187 YRQRYVDLIVTPETRTTFRARTKAIASIRKFMGDADFMEVETPMLHPIPGGAAAKPFVTH 246 Query: 239 Y--FKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFN 296 + +L +P+LY + I FE+VF I FR E + RH EF ++ A+ Sbjct: 247 HNALDMEMFLRIAPELYLKRLIVGGFERVFEINRNFRNE-GVSPRHNPEFTMMEFYAAYT 305 Query: 297 YHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEAL---- 352 Y +M+ + +++ + T Q+ +P RL +A+ Sbjct: 306 -DYRWLMDFTE-------RLIRQAAVDALGTATIQYQGRELDLAQPFHRLTITQAIQKYA 357 Query: 353 ---------------AMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFY----ILDK 393 + L+ GV++ L+ L L +E + + I+D Sbjct: 358 PSYTDGQLSDDAFLRSELKRLGVDVTQPAFLNAGIGALQLALFEETAEAQLWEPTFIID- 416 Query: 394 YPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIK 453 YP+ V P D + +++F+ G EI +G ++DP+ ++A +E+ Sbjct: 417 YPIEVSPLARESD-TVAGITERFELFITGREIANGFSELNDPE---DQAARFKKQVEQKD 472 Query: 454 A-----------YIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFP 493 A YI + +G PP G GIG++R+ ML +R +FP Sbjct: 473 AGDEEAMFFDADYIRALEYGMPPTGGCGIGIDRLVMLLTDSPTIRDVLLFP 523 >5HGQ-A nrPDB Length = 524 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 88/371 (23%), Positives = 146/371 (39%), Gaps = 72/371 (19%) Query: 175 NQDTRLDNRVIDLRTSTS-QAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGAN 233 NQ+TR R +DL + + F +S + R L N GF+E++TP + A A Sbjct: 156 NQETRYRMRYLDLIMNPDVKNRFVTRSRMISFLRRYLDNLGFLEVETPMMNLIAGGATAK 215 Query: 234 VFTVSY--FKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDI 291 F + + YL +P+LY +M + ++V+ IG VFR E + H EF + Sbjct: 216 PFITHHNDLDMDLYLRVAPELYLKMLVVGGIDRVYEIGRVFRNEGID-QTHNPEFTSCEF 274 Query: 292 EMAFNYHYHEVMEEIADTM------------------------------------VQIFK 315 MA+ Y ++M+ D + V I+ Sbjct: 275 YMAYA-DYEDLMKITEDMLARMVYYMHGTYKIQYHPNGIVENPVYEVDFTPPFRKVNIYD 333 Query: 316 GLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKL 375 GLQE+ QFP P L+ EA + VE E +L Sbjct: 334 GLQEKLGI-------QFP--------PADTLDTDEANKFFDKLAVENNVECPAPRTTARL 378 Query: 376 LGHLVKEKYDTDFY---ILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRI 432 L L+ E + F L +P + P P + +++F+ +EI++ + Sbjct: 379 LDKLIGEFLEPTFISPTFLTGHPQIMSPLAKW-HRSIPGLTERFELFVVTKEIVNAYTEL 437 Query: 433 HDPQLLTERALHHGIDLEKIKA----------YIDSFRFGAPPHAGGGIGLERVTMLFLG 482 +DP LT+R +K Y + +G PP AG G+G++R+ M+ Sbjct: 438 NDP--LTQRLRFDEQAKQKQAGDDEAQNIDENYCTALEYGLPPTAGWGMGIDRLAMILTD 495 Query: 483 LHNVRQTSMFP 493 +N+++ FP Sbjct: 496 SNNIKEVLFFP 506 >4AH6-A nrPDB Length = 617 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 68/240 (28%), Positives = 111/240 (46%), Gaps = 28/240 (11%) Query: 61 WVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVV 120 W++ R + FLVLR VQ ++ D ++ + K ES+V V G V Sbjct: 32 WIQYRRQNT-------FLVLRDFDGLVQVIIP-QDESAASVKKILCEAPVESVVQVSGTV 83 Query: 121 --RKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDT 178 R Q+ ++E+ V+ +++ + +LP ++ + V+ + Sbjct: 84 ISRPAGQENPKMPTGEIEIKVKTAELLNACK-KLPFEIKNFVKK------------TEAL 130 Query: 179 RLDNRVIDLRTSTSQAVFRLQSGICHLFRETLIN-KGFVEIQTPKIISAASEGGANVFTV 237 RL R +DLR+ Q RL+S + RE L N GFV+I+TP + + GGA F V Sbjct: 131 RLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKR-TPGGAKEFLV 189 Query: 238 SYFKNNAY--LAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAF 295 + + L QSPQ +KQ+ + ++ F + +R E S R EF +DIEM+F Sbjct: 190 PSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIEMSF 248 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 32/105 (30%), Positives = 56/105 (53%), Gaps = 14/105 (13%) Query: 402 YTMPDPRN-------PKQSNS--YDMFMRGEEILSGAQRIHDPQLLTERALHHGI---DL 449 +T P P + PK++ S YD+ + G EI G+ RIH+ +L +R + + D+ Sbjct: 465 FTAPHPSDIHLLYTEPKKARSQHYDLVLNGNEIGGGSIRIHNAEL--QRYILATLLKEDV 522 Query: 450 EKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPR 494 + + + + +GAPPH G +GL+R+ L G ++R FP+ Sbjct: 523 KMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPK 567 >4WJ3-M nrPDB Length = 599 Score = 79.0 bits (193), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 77/281 (27%), Positives = 126/281 (44%), Gaps = 37/281 (13%) Query: 66 VHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVR---- 121 VH R G FL +R ++ Q V D + A + E +V + G VR Sbjct: 33 VHRRRDHGGVIFLDVRDREGLAQV---VFDPDRAETFAKADRVRSEFVVKITGKVRLRPE 89 Query: 122 -KVNQKIGSCTQQDVELHVQKIYVISLAE-PRLPLQLDDAVRPEAEGEEEGRATVNQDTR 179 N + S + +E+ ++ V++ AE P PL + + V ++TR Sbjct: 90 GARNPNMASGS---IEVLGYELEVLNQAETPPFPL--------------DEYSDVGEETR 132 Query: 180 LDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVS- 238 L R IDLR A +L++ I R L + GF++++TP + EG + S Sbjct: 133 LRYRFIDLRRPEMAAKLKLRARITSSIRRYLDDNGFLDVETPILGRPTPEGARDYLVPSR 192 Query: 239 -YFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNY 297 Y + L QSPQL+KQ+ + A F++ + I FR ED R EF +DIE +F Sbjct: 193 TYPGHFFALPQSPQLFKQLLMVAGFDRYYQIAKCFRDEDLRADRQ-PEFTQIDIETSF-- 249 Query: 298 HYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFK 338 ++E +D + K +++ F+ + +FP PF+ Sbjct: 250 -----LDE-SDIIGITEKMVRQLFKEVLDVEFDEFPHMPFE 284 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 32/86 (37%), Positives = 47/86 (54%), Gaps = 4/86 (4%) Query: 413 SNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDL----EKIKAYIDSFRFGAPPHAG 468 S +YDM + G E+ G+ RIHD + GID EK +D+ ++GAPPH G Sbjct: 480 SRAYDMVLNGTELGGGSIRIHDKSMQQAVFRVLGIDEAEQEEKFGFLLDALKYGAPPHGG 539 Query: 469 GGIGLERVTMLFLGLHNVRQTSMFPR 494 GL+R+ ML G ++R+ FP+ Sbjct: 540 LAFGLDRLVMLMTGASSIREVIAFPK 565 >1IL2-A nrPDB Length = 590 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 70/263 (26%), Positives = 114/263 (43%), Gaps = 29/263 (11%) Query: 61 WVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVV 120 WV R R G F+ +R ++ VQ D +K A+ + E + V G V Sbjct: 23 WVNRR----RDLGSLIFIDMRDREGIVQVFF---DPDRADALKLASELRNEFCIQVTGTV 75 Query: 121 RKVNQKIGS--CTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDT 178 R ++K + ++E+ + +I+ A+ LPL + EA Sbjct: 76 RARDEKNINRDMATGEIEVLASSLTIINRADV-LPLDSNHVNTEEA-------------- 120 Query: 179 RLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVS 238 RL R +DLR + ++ I L R + + GF++I+TP + A EG + S Sbjct: 121 RLKYRYLDLRRPEMAQRLKTRAKITSLVRRFMDDHGFLDIETPMLTKATPEGARDYLVPS 180 Query: 239 YFKNNAY--LAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFN 296 + L QSPQL+KQ+ + + F++ + I FR ED R EF +D+E +F Sbjct: 181 RVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQ-PEFTQIDVETSFM 239 Query: 297 Y--HYHEVMEEIADTMVQIFKGL 317 EVME + + KG+ Sbjct: 240 TAPQVREVMEALVRHLWLEVKGV 262 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 32/86 (37%), Positives = 48/86 (55%), Gaps = 4/86 (4%) Query: 413 SNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGID----LEKIKAYIDSFRFGAPPHAG 468 +N+YDM + G E+ G+ RIH+ + GI+ EK +D+ ++G PPHAG Sbjct: 471 ANAYDMVINGYEVGGGSVRIHNGDMQQTVFGILGINEEEQREKFGFLLDALKYGTPPHAG 530 Query: 469 GGIGLERVTMLFLGLHNVRQTSMFPR 494 GL+R+TML G N+R FP+ Sbjct: 531 LAFGLDRLTMLLTGTDNIRDVIAFPK 556 >6NRZ-A nrPDB Length = 534 Score = 75.5 bits (184), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 81/355 (22%), Positives = 156/355 (43%), Gaps = 44/355 (12%) Query: 175 NQDTRLDNRVIDLRTSTS-QAVFRLQSGICHLFRETLINKGFVEIQTP--KIISAASEGG 231 +++ R R DL +S + F +S I L RE + + F+E++TP + + +E Sbjct: 178 DKEIRYRKRWADLISSEDVRKTFLTRSRILKLIREYMDQQSFLEVETPILQTVYGGAEAT 237 Query: 232 ANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDI 291 V T+ +L S ++ + + +V+ IG VFR E + H EF ++ Sbjct: 238 PFVTTLQALHAEMFLRISLEIALKKLLVGGMSRVYEIGKVFRNEGID-RTHNPEFTMIEA 296 Query: 292 EMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEA 351 A+ + Y++VM+ + + + I + L +T++Q + + + F P +R+ E+ Sbjct: 297 YAAY-WDYNDVMKCVENLVEYIVRALNNG-ETQVQYSHLKSGPQVVDFKAPWIRMTMKES 354 Query: 352 LAMLREAGVEMGDEDDL--------STPNEK------------LLGHLVKEKYDTDFYIL 391 +++ V++ + +L S P + L LV +K +I Sbjct: 355 ISVYGGVDVDLHADHELRKILETQTSLPEKTYVHASRGELIALLFDELVCDKLIAPHHIT 414 Query: 392 DKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDP----QLLTE----RAL 443 D +PL P + ++ F G+E+ + ++DP +LL E +AL Sbjct: 415 D-HPLETTPLCKTLRSGDETLVERFESFCLGKELCNAYSELNDPLQQRKLLEEQMRKKAL 473 Query: 444 -----HHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFP 493 +H ID E ++++ G PP G GIG++R+ M+ ++R FP Sbjct: 474 NPDSEYHPIDEE----FLEALCQGMPPAGGFGIGIDRLVMMLTDAASIRDVLFFP 524 >1EFW-A nrPDB Length = 580 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 79/263 (30%), Positives = 121/263 (46%), Gaps = 18/263 (6%) Query: 56 ADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVD 115 +EVV + V+ R G FL LR ++ VQ LVA H + A + E +V Sbjct: 16 GEEVV-LEGWVNRRRDLGGLIFLDLRDREGLVQ-LVA---HPASPAYATAERVRPEWVVR 70 Query: 116 VEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVN 175 +G+VR + VE+ + + V++ A+ P +D R E E + Sbjct: 71 AKGLVRLRPEPNPRLATGRVEVELSALEVLAEAK-TPPFPVDAGWRGEEE------KEAS 123 Query: 176 QDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVF 235 ++ RL R +DLR Q RL+ + + L +GFV+++TP + + EG A F Sbjct: 124 EELRLKYRYLDLRRRRMQENLRLRHRVIKAIWDFLDREGFVQVETPFLTKSTPEG-ARDF 182 Query: 236 TVSYFKNNAY---LAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIE 292 V Y L QSPQL+KQM + A ++ F I FR ED R +F LD+E Sbjct: 183 LVPYRHEPGLFYALPQSPQLFKQMLMVAGLDRYFQIARCFRDEDLRADRQ-PDFTQLDLE 241 Query: 293 MAFNYHYHEVMEEIADTMVQIFK 315 M+F +V+E M +F+ Sbjct: 242 MSF-VEVEDVLELNERLMAHVFR 263 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 36/122 (29%), Positives = 58/122 (47%), Gaps = 17/122 (13%) Query: 378 HLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQL 437 H + D +L+K P VR + +YD+ + G E+ G+ RIHDP+L Sbjct: 443 HPFTSPHPEDLPLLEKDPGRVR-------------ALAYDLVLNGVEVGGGSIRIHDPRL 489 Query: 438 LTERALHHGID----LEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFP 493 GI EK ++++ +GAPPH G GL+R+ L G ++R+ FP Sbjct: 490 QARVFRLLGIGEEEQREKFGFFLEALEYGAPPHGGIAWGLDRLLALMTGSPSIREVIAFP 549 Query: 494 RD 495 ++ Sbjct: 550 KN 551 >1NNH-A nrPDB Length = 294 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 72/312 (23%), Positives = 125/312 (40%), Gaps = 53/312 (16%) Query: 198 LQSGICHLFRETLINKGFVEIQTPKIISAASEG--------GANVFTVSYFKNNAYLAQS 249 +Q+ I + + +GF + P IIS ++ G V + L S Sbjct: 17 IQTKILEYMTDFFVKEGFKWL-LPVIISPITDPLWPDPAGEGMEPAEVEIYGVKMRLTHS 75 Query: 250 PQLYKQMCICADFEKVFSIGPVFRAED--SNTHRHLTEFVGLDIEMAFNYHYHEVMEEIA 307 L+KQ+ I +K+F + P R E + RH EF LD E+ ME+I Sbjct: 76 MILHKQLAIAMGLKKIFVLSPNIRLESRQKDDGRHAYEFTQLDFEVE-----RAKMEDIM 130 Query: 308 DTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDD 367 + ++ GL F+ + ++FP T R E E +L E G + + Sbjct: 131 RLIERLVYGL---FRKAEEWTGREFPK--------TKRFEVFEYSEVLEEFGSDEKASQE 179 Query: 368 LSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFM--RGEEI 425 + P F+I++ R FY D +YD+ + E+ Sbjct: 180 MEEP----------------FWIIN----IPREFY---DREVDGFWRNYDLILPYGYGEV 216 Query: 426 LSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGA-PPHAGGGIGLERVTMLFLGLH 484 SG +R + + + + G++ + + Y++ + G P AG GIG+ER+ +G Sbjct: 217 ASGGEREWEYEKIVAKIRKAGLNEDSFRPYLEIAKAGKLKPSAGAGIGVERLVRFIVGAK 276 Query: 485 NVRQTSMFPRDP 496 ++ + FPR P Sbjct: 277 HIAEVQPFPRIP 288 >4UP8-A nrPDB Length = 777 Score = 55.1 bits (131), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 41/148 (27%), Positives = 72/148 (48%), Gaps = 8/148 (5%) Query: 175 NQDTRLDNRVIDLRTST-SQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGAN 233 +Q+TR R +DL + S F L++ + R+ L +KGF+E++TP + + A Sbjct: 158 DQETRFRKRYLDLIVNPESVKNFVLRTKVVKAVRKYLDDKGFLEVETPILNTIPGGATAR 217 Query: 234 VFTVSY--FKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDI 291 F + Y+ +P+LY + + +V+ IG +FR E + H EF + Sbjct: 218 PFITHHNQLDIQMYMRIAPELYLKELVVGGINRVYEIGRLFRNEGID-QTHNPEFTTCEF 276 Query: 292 EMAFNYHYHEVM---EEIADTMVQIFKG 316 MA+ Y+++M EE+ MV+ G Sbjct: 277 YMAY-ADYNDIMKMTEELLGNMVKDITG 303 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 28/131 (21%), Positives = 62/131 (47%), Gaps = 14/131 (10%) Query: 373 EKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRI 432 +KL G L++ ++ D+ P + P P+ + +++F+ EI + + Sbjct: 439 DKLFGDLIEVDLVQPTFVCDQ-PQLMSPLAKY-HRSEPELTERFELFILKREIANAYTEL 496 Query: 433 HDP--------QLLTERALHHGIDLEKI--KAYIDSFRFGAPPHAGGGIGLERVTMLFLG 482 ++P Q ++A G D ++ + ++D+ PP G G+G++R+ ML Sbjct: 497 NNPIVQRSNFEQQAKDKA--AGDDEAQLVDEVFLDAIEHAFPPTGGWGLGIDRLAMLLAD 554 Query: 483 LHNVRQTSMFP 493 + N+++ +FP Sbjct: 555 VDNIKEVILFP 565 >3P8T-A nrPDB Length = 294 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 63/257 (24%), Positives = 104/257 (40%), Gaps = 46/257 (17%) Query: 246 LAQSPQLYKQMCICADFEKVFSIGPVFRAED--SNTHRHLTEFVGLDIEMAFNYHYHEVM 303 L S L+KQ+ I EK+F + P R E + RH EF LD E+ +VM Sbjct: 72 LTHSMILHKQLAIAMGLEKIFVLSPNIRLESRRKDDGRHSYEFTQLDFEIE-GAKMKDVM 130 Query: 304 EEIADTMVQIFKGLQERFQTEIQTVNKQFP-CEPFKFLEPTLRLEYCEALAMLREAGVEM 362 I + + +F+ +E ++FP FK + LE E Sbjct: 131 RLIEELIYGLFRKAEE-------WTGREFPRARHFKVYDYKDILE-------------EF 170 Query: 363 GDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFM-- 420 G ++ S E+ F+I++ R FY D +YD+ + Sbjct: 171 GSDEKASMEMEE------------PFWIVN----IPREFY---DREENGVWKNYDLILPY 211 Query: 421 RGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGA-PPHAGGGIGLERVTML 479 E+ SG +R + + + + G+ + + Y++ R G P AG GIG+ER+ Sbjct: 212 GYGEVSSGGEREWEYEKIVAKIRAAGLKEDSFRPYLEIARAGKLKPSAGAGIGVERLVRF 271 Query: 480 FLGLHNVRQTSMFPRDP 496 +G ++ + FPR P Sbjct: 272 IVGAKHIAEVQPFPRVP 288 >3G1Z-A nrPDB Length = 326 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 68/318 (21%), Positives = 131/318 (41%), Gaps = 34/318 (10%) Query: 199 QSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTV-SYFKN-------NAYLAQSP 250 ++ I R ++G +E++TP +S A+ ++F + F N YL SP Sbjct: 20 RAAIMAEIRRFFADRGVLEVETP-CMSQATVTDIHLFPFETRFVGPGHSQGINLYLMTSP 78 Query: 251 QLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTM 310 + + + + A VF + FR E+ H H EF L+ +Y + +M E+ D + Sbjct: 79 EYHMKRLLAAGCGPVFQLCRSFRNEEMGRH-HNPEFTMLEWYRP-HYDMYRLMNEVDDLL 136 Query: 311 VQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLST 370 Q+ + Q + +P + LR EA A L + + E+D T Sbjct: 137 QQVLDCQPAESLSYQQAFQRHLEIDPLSADKTQLR----EAAAKLDLSNI-ADTEEDRDT 191 Query: 371 PNEKLLG-----HLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEI 425 + L H+ KEK ++ +P A + + + + ++++ +G E+ Sbjct: 192 LLQLLFTMGVEPHIGKEKPTFIYH----FP-ASQASLAQISTEDHRVAERFEVYYKGIEL 246 Query: 426 LSGAQRIHDPQLLTER-------ALHHGIDLEKI-KAYIDSFRFGAPPHAGGGIGLERVT 477 +G + D + +R G+ + I + +D+ G P +G +G++R+ Sbjct: 247 ANGFHELTDAREQQQRFEQDNRKRAARGLPQQPIDQNLLDALAAGLPDCSGVALGVDRLV 306 Query: 478 MLFLGLHNVRQTSMFPRD 495 ML LG ++ F D Sbjct: 307 MLALGAESLADVIAFTVD 324 >3G9Q-A nrPDB Length = 279 Score = 35.4 bits (80), Expect = 0.055, Method: Compositional matrix adjust. Identities = 23/96 (23%), Positives = 44/96 (45%), Gaps = 11/96 (11%) Query: 412 QSNSYDMFMRGEEILSGAQRIHD------PQLLTERALHHG-----IDLEKIKAYIDSFR 460 Q+N D+++ G++ G I+ +L E+A+ G I LEK+ + + Sbjct: 152 QTNGKDIYVFGKDFGRGGSIIYKDLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYI 211 Query: 461 FGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDP 496 F P +GG G + ++ L+ V+ ++ DP Sbjct: 212 FAGPWQSGGDDGGVFESSIWKNLNAVKNGHVYKMDP 247 >6JP2-A nrPDB Length = 278 Score = 33.1 bits (74), Expect = 0.31, Method: Compositional matrix adjust. Identities = 27/97 (27%), Positives = 45/97 (46%), Gaps = 14/97 (14%) Query: 208 ETLINKGFVEIQTPKIISAASEGGANVF-TVSYFKNNAYLAQ--------SPQLYKQMCI 258 + L+ +GF+E++TP IS + + FK ++ + +P LY M Sbjct: 75 DALVAEGFIEVRTPIFISKDALARMTITEDKPLFKQVFWIDEKRALRPMLAPNLYSVMRD 134 Query: 259 CADFE----KVFSIGPVFRAEDSNTHRHLTEFVGLDI 291 D K+F +G FR E S++ HL EF L++ Sbjct: 135 LRDHTDGPVKIFEMGSCFRKE-SHSGMHLEEFTMLNL 170 >3VQX-A nrPDB Length = 291 Score = 31.6 bits (70), Expect = 0.85, Method: Compositional matrix adjust. Identities = 28/96 (29%), Positives = 43/96 (44%), Gaps = 18/96 (18%) Query: 210 LINKGFVEIQTPKII----------SAASEGGANVFTVSYFKNNAYLAQ-SPQLYKQMC- 257 +++GF+EI++P +I +E +F V KN +P LY + Sbjct: 91 FVDRGFLEIKSPILIPLEYIERMGIDNDTELSKQIFRVD--KNFCLRPMLAPNLYNYLRK 148 Query: 258 ---ICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLD 290 D K+F IGP +R E S+ HL EF L+ Sbjct: 149 LDRALPDPIKIFEIGPCYRKE-SDGKEHLEEFTMLN 183 >11AS-A nrPDB Length = 330 Score = 28.9 bits (63), Expect = 5.1, Method: Compositional matrix adjust. Identities = 34/126 (26%), Positives = 50/126 (39%), Gaps = 29/126 (23%) Query: 364 DEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGE 423 D DD STP+E LGH + D + NP +++ Sbjct: 217 DYDDWSTPSE--LGH---AGLNGDILVW-----------------NPVLEDAF------- 247 Query: 424 EILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGL 483 E+ S R+ L + AL D +++ + R P GGGIG R+TML L L Sbjct: 248 ELSSMGIRVDADTLKHQLALTGDEDRLELEWHQALLRGEMPQTIGGGIGQSRLTMLLLQL 307 Query: 484 HNVRQT 489 ++ Q Sbjct: 308 PHIGQV 313 >6D6R-H nrPDB Length = 296 Score = 28.5 bits (62), Expect = 6.7, Method: Compositional matrix adjust. Identities = 19/69 (27%), Positives = 33/69 (47%), Gaps = 3/69 (4%) Query: 95 DHASKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPL 154 +H ++ F AN+ S+ D E + R N I TQ+ + + ++ E LP Sbjct: 213 EHKEEEAGGFIANLEPVSLADREVISRLRNCIISLVTQR---MMLYDTSILYCYEASLPH 269 Query: 155 QLDDAVRPE 163 Q+ D ++PE Sbjct: 270 QIKDILKPE 278 >6C70-A nrPDB Length = 478 Score = 28.5 bits (62), Expect = 8.0, Method: Compositional matrix adjust. Identities = 19/59 (32%), Positives = 28/59 (47%), Gaps = 5/59 (8%) Query: 180 LDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVS 238 NR+I+ +S +A + CH + + K FV+I + A S GA FTVS Sbjct: 403 FGNRLIEESSSVMEAAYS-----CHWYDGSEEAKTFVQIVCQQCQKAMSISGAKFFTVS 456 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4J15-A nrPDB 651 0.0 3I7F-A nrPDB 544 e-155 1ASZ-A nrPDB 522 e-148 6OD8-A nrPDB 503 e-143 3NEM-A nrPDB 454 e-128 1WYD-A nrPDB 434 e-122 3M4P-A nrPDB 414 e-116 5XIX-A nrPDB 409 e-114 2XGT-A nrPDB 400 e-112 1N9W-A nrPDB 396 e-111 1X54-A nrPDB 393 e-110 1LYL-A nrPDB 383 e-106 6CHD-A nrPDB 378 e-105 1BBU-A nrPDB 378 e-105 6ILH-A nrPDB 377 e-105 4YCV-A nrPDB 373 e-103 4EX5-A nrPDB 373 e-103 3A74-A nrPDB 370 e-103 5ZG8-A nrPDB 364 e-101 5ELO-A nrPDB 362 e-100 5HGQ-A nrPDB 354 7e-98 6AQG-A nrPDB 347 4e-96 6NRZ-A nrPDB 326 2e-89 6AQH-A nrPDB 317 9e-87 5W25-A nrPDB 253 1e-67 4RMF-A nrPDB 246 2e-65 4WJ3-M nrPDB 242 3e-64 1IL2-A nrPDB 240 9e-64 3G1Z-A nrPDB 228 6e-60 4UP8-A nrPDB 219 3e-57 1EFW-A nrPDB 218 6e-57 4AH6-A nrPDB 216 2e-56 1NNH-A nrPDB 201 5e-52 3P8T-A nrPDB 196 2e-50 Sequences not found previously or not previously below threshold: 3A5Z-A nrPDB 213 1e-55 5GRO-A nrPDB 69 4e-12 3VQX-A nrPDB 58 7e-09 2ZNJ-A nrPDB 54 1e-07 6JP2-A nrPDB 46 3e-05 11AS-A nrPDB 45 1e-04 4LNS-A nrPDB 40 0.002 3TUP-A nrPDB 39 0.007 5LR8-A nrPDB 36 0.032 3L4G-A nrPDB 34 0.20 2NSM-A nrPDB 31 0.98 2ODR-C nrPDB 31 0.99 1ADJ-A nrPDB 31 1.0 2ALY-A nrPDB 31 1.3 4P71-C nrPDB 31 1.8 1UMG-A nrPDB 31 1.8 3AMU-A nrPDB 30 2.0 1PYS-A nrPDB 30 2.1 2DU4-A nrPDB 30 2.5 3PCO-A nrPDB 30 3.1 4WZY-A nrPDB 29 3.4 3MKD-A nrPDB 29 4.8 2JJ9-A nrPDB 29 5.2 1KA4-A nrPDB 29 5.8 3AU7-A nrPDB 29 6.7 5VM7-A nrPDB 29 6.8 >4J15-A nrPDB Length = 521 Score = 651 bits (1679), Expect = 0.0, Method: Composition-based stats. Identities = 501/501 (100%), Positives = 501/501 (100%) Query: 1 MPSASASRKSQEKPREIMDAAEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADEVV 60 MPSASASRKSQEKPREIMDAAEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADEVV Sbjct: 21 MPSASASRKSQEKPREIMDAAEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADEVV 80 Query: 61 WVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVV 120 WVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVV Sbjct: 81 WVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVV 140 Query: 121 RKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRL 180 RKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRL Sbjct: 141 RKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRL 200 Query: 181 DNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYF 240 DNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYF Sbjct: 201 DNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYF 260 Query: 241 KNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYH 300 KNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYH Sbjct: 261 KNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYH 320 Query: 301 EVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGV 360 EVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGV Sbjct: 321 EVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGV 380 Query: 361 EMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFM 420 EMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFM Sbjct: 381 EMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFM 440 Query: 421 RGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLF 480 RGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLF Sbjct: 441 RGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLF 500 Query: 481 LGLHNVRQTSMFPRDPKRLTP 501 LGLHNVRQTSMFPRDPKRLTP Sbjct: 501 LGLHNVRQTSMFPRDPKRLTP 521 >3I7F-A nrPDB Length = 548 Score = 544 bits (1402), Expect = e-155, Method: Composition-based stats. Identities = 255/544 (46%), Positives = 336/544 (61%), Gaps = 46/544 (8%) Query: 3 SASASRKSQEKPREIMDAAEDYAKERYGISSMIQSQE--KPDRVLVRVRDLTIQKADEVV 60 +A+ +K Q P ++ E + E + + M QSQ K + +L A++ V Sbjct: 6 AATQEKKPQLPPVVLLKTPELVSGENFKVMPMHQSQPCYKTGLKYTEIEELVPAMAEKTV 65 Query: 61 WVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVV 120 +RARV R KG FL LR+ + QALV + SK+ V+F I+ ESI D+ G+V Sbjct: 66 TIRARVQAVRGKGNMVFLFLRKGIYTCQALVMKSETISKEFVQFCQKISAESICDITGIV 125 Query: 121 RKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEA---------------- 164 + V + I TQQDVE+HV I V+SLAE LP+Q++D P + Sbjct: 126 KAVEKPIEKATQQDVEIHVTSIAVVSLAEYPLPMQIEDLTFPSSVFKKQEEDIAKVDEKI 185 Query: 165 ---------------------------EGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFR 197 + + V+QDTRLDNR++DLRT T+ A+FR Sbjct: 186 AKFLKDNEGKDLTKRPLKDEYAKLLKEKASAQKYVKVSQDTRLDNRMLDLRTVTNIAIFR 245 Query: 198 LQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMC 257 +QS C LFRE L ++ FVEI TPK+I +SEGG+N+F V YF AYLAQSPQLYKQM Sbjct: 246 IQSACCGLFREFLTSQKFVEIHTPKLIGCSSEGGSNIFEVKYFDRKAYLAQSPQLYKQMA 305 Query: 258 ICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIFKGL 317 I DF KVF +GPVFRAE+SNT RHLTEF GLDIEM +YHE ++ + IF + Sbjct: 306 IMGDFRKVFEVGPVFRAENSNTRRHLTEFEGLDIEMEIVENYHECIDVMEKLFTFIFDEI 365 Query: 318 QERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLG 377 +RF E++ + KQ+P E P LRL Y EA+ MLR +G +GD DD +TP E LG Sbjct: 366 PKRFPDELKVIRKQYPFEDL-IYRPFLRLTYKEAIEMLRASGETIGDYDDFTTPQEVKLG 424 Query: 378 HLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQL 437 L+K KY+TDFYILDK+P A+RPFYTMPD +P SNSYD+F+RG+EI SGAQRIHDP+ Sbjct: 425 ELIKAKYNTDFYILDKFPAAIRPFYTMPDIDDPNYSNSYDVFVRGQEITSGAQRIHDPEF 484 Query: 438 LTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPK 497 L +R + G+D +K YI+SFRFG+ PHAG GIGLER+TML+LG+ N+R+ ++FPRDP Sbjct: 485 LMKRCIEKGVDPATLKDYIESFRFGSWPHAGCGIGLERITMLYLGIPNIRKVTLFPRDPI 544 Query: 498 RLTP 501 RL P Sbjct: 545 RLNP 548 >1ASZ-A nrPDB Length = 490 Score = 522 bits (1345), Expect = e-148, Method: Composition-based stats. Identities = 281/490 (57%), Positives = 346/490 (70%), Gaps = 10/490 (2%) Query: 22 EDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKA---DEVVWVRARVHTSRAKG-KQCF 77 ED AK+ YG +IQS++ RV+ + + +A D+ V RARVH +R +G F Sbjct: 1 EDTAKDNYGKLPLIQSRDSDRTGQKRVKFVDLDEAKDSDKEVLFRARVHNTRQQGATLAF 60 Query: 78 LVLRQQQFNVQALVAVGDHA--SKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQQDV 135 L LRQQ +Q LV SK MVK+A ++N ESIV V G+V+KV++ I S T Q++ Sbjct: 61 LTLRQQASLIQGLVKANKEGTISKNMVKWAGSLNLESIVLVRGIVKKVDEPIKSATVQNL 120 Query: 136 ELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAV 195 E+H+ KIY IS LP+ L+DA R EAE E G VN DTRLD RVIDLRT T+QA+ Sbjct: 121 EIHITKIYTISETPEALPILLEDASRSEAEAEAAGLPVVNLDTRLDYRVIDLRTVTNQAI 180 Query: 196 FRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQ 255 FR+Q+G+C LFRE L K F E+ TPK++ A SEGG++VF V+YFK AYLAQSPQ KQ Sbjct: 181 FRIQAGVCELFREYLATKKFTEVHTPKLLGAPSEGGSSVFEVTYFKGKAYLAQSPQFNKQ 240 Query: 256 MCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIFK 315 I ADFE+V+ IGPVFRAE+SNTHRH+TEF GLD+EMAF HYHEV++ +++ V IF Sbjct: 241 QLIVADFERVYEIGPVFRAENSNTHRHMTEFTGLDMEMAFEEHYHEVLDTLSELFVFIFS 300 Query: 316 GLQERFQTEIQTVNKQFPCEPFKFLEP--TLRLEYCEALAMLREAGVEMGDEDDLSTPNE 373 L +RF EI+ V KQ+P E FK + +RL Y E + MLR AG E+GD +DLST NE Sbjct: 301 ELPKRFAHEIELVRKQYPVEEFKLPKDGKMVRLTYKEGIEMLRAAGKEIGDFEDLSTENE 360 Query: 374 KLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIH 433 K LG LV++KYDTDFYILDK+PL +RPFYTMPDP NPK SNSYD FMRGEEILSGAQRIH Sbjct: 361 KFLGKLVRDKYDTDFYILDKFPLEIRPFYTMPDPANPKYSNSYDFFMRGEEILSGAQRIH 420 Query: 434 DPQLLTERALHHGIDLEK--IKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSM 491 D LL ER HG+ E +K Y D F +G PPHAGGGIGLERV M +L L N+R+ S+ Sbjct: 421 DHALLQERMKAHGLSPEDPGLKDYCDGFSYGCPPHAGGGIGLERVVMFYLDLKNIRRASL 480 Query: 492 FPRDPKRLTP 501 FPRDPKRL P Sbjct: 481 FPRDPKRLRP 490 >6OD8-A nrPDB Length = 558 Score = 503 bits (1296), Expect = e-143, Method: Composition-based stats. Identities = 255/535 (47%), Positives = 328/535 (61%), Gaps = 42/535 (7%) Query: 3 SASASRKSQEKPREIMDAA--EDYAKERYGISSMIQSQEKPDRVLVRVRDLT-IQKADEV 59 + A+R ++EK R AA E Y K +G + M+QS R + V +L+ + D+ Sbjct: 30 ARKAARLAEEKARADEKAALVEKY-KAVFGAAPMVQSTTYKSRTHIPVSELSRPELVDKT 88 Query: 60 VWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGV 119 V +RARV T+R KGK F+VLR +VQA+ AV K+M+ F I ESIVDVE Sbjct: 89 VLIRARVSTTRKKGKMAFMVLRDGSDSVQAMAAVEGDVPKEMIDFMGQIATESIVDVEAT 148 Query: 120 VRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTR 179 V KV Q I S + D+EL V+KI+ ++ + LP L+DA R E+ A VN DTR Sbjct: 149 VCKVEQPITSTSHSDIELKVKKIHTVTESLRTLPFTLEDASRKESAEG----AKVNLDTR 204 Query: 180 LDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSY 239 L++R +DLRT S A+FRLQS +C FR+ LI+K F EI +PKII+A SEGGANVF + Y Sbjct: 205 LNSRWMDLRTLASGAIFRLQSRVCQYFRQFLIDKDFCEIHSPKIINAPSEGGANVFKLEY 264 Query: 240 FKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHY 299 F AYLAQSPQLYKQM + D +VF +GPVFR+E+SNTHRHLTEFVGLD+EM + HY Sbjct: 265 FNRFAYLAQSPQLYKQMVLQGDVPRVFEVGPVFRSENSNTHRHLTEFVGLDVEMRIDEHY 324 Query: 300 HEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKF-------------------- 339 +EV++ IF+ L E++ V +Q+P EP + Sbjct: 325 YEVLDVAESLFNYIFERL-ATHTKELKNVCQQYPFEPLVWKLTPERIKELGVGVISEGVV 383 Query: 340 ------------LEPTLRLEYCEALAMLREAGVE-MGDEDDLSTPNEKLLGHLVKEKYDT 386 LR+ Y + +L E M DD++T NEKLLG LVKE+Y T Sbjct: 384 PTDKFQARVHNMDSRMLRINYMHCIELLNTVLDEKMAPTDDINTTNEKLLGKLVKERYGT 443 Query: 387 DFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHG 446 DF+I D++P + RPFYTM + + +NSYDMF+RGEEI SGAQRIHDP LL RA Sbjct: 444 DFFISDRFPSSARPFYTMECKDDVRFTNSYDMFIRGEEISSGAQRIHDPDLLLARAKMLN 503 Query: 447 IDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501 +DL IK Y+DSFR GA PH G GIGLERV ML+LGL NVR S+FPRDP+R TP Sbjct: 504 VDLTPIKEYVDSFRLGAWPHGGFGIGLERVVMLYLGLSNVRLASLFPRDPQRTTP 558 >3NEM-A nrPDB Length = 438 Score = 454 bits (1168), Expect = e-128, Method: Composition-based stats. Identities = 156/453 (34%), Positives = 236/453 (52%), Gaps = 22/453 (4%) Query: 49 RDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANI 108 ++T + + V V V + G FL +R + VQ + A ++ K + Sbjct: 8 SEITEELNGQKVKVAGWVWEVKDLGGIKFLWIRDRDGIVQ-ITAPKKKVDPELFKLIPKL 66 Query: 109 NKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEE 168 E +V VEGVV + + E+ +KI V++ AE LPL Sbjct: 67 RSEDVVAVEGVVNFTPK-----AKLGFEILPEKIVVLNRAETPLPLD------------P 109 Query: 169 EGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAAS 228 G+ DTRLDNR +DLR A+F+++S + R+ GF+EI TPKII+ A+ Sbjct: 110 TGKVKAELDTRLDNRFMDLRRPEVMAIFKIRSSVFKAVRDFFHENGFIEIHTPKIIATAT 169 Query: 229 EGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVG 288 EGG +F + YF+ +A+LAQSPQLYKQ+ + + ++V+ I P+FRAE+ NT RHL E Sbjct: 170 EGGTELFPMKYFEEDAFLAQSPQLYKQIMMASGLDRVYEIAPIFRAEEHNTTRHLNEAWS 229 Query: 289 LDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEY 348 +D EMAF EVM + + ++E E+ +N + P R+ Y Sbjct: 230 IDSEMAFIEDEEEVMSFLERLVAHAINYVREHNAKELDILNFELEEPKL----PFPRVSY 285 Query: 349 CEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPR 408 +AL +L + G E+ +D+ T E+LLG + E + Y L +YP +PFY M Sbjct: 286 DKALEILGDLGKEIPWGEDIDTEGERLLGKYMMENENAPLYFLYQYPSEAKPFYIMKYDN 345 Query: 409 NPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAG 468 P+ ++D+ RG EI SG QR H +L E+ G++ E + Y+ +FR+G PPH G Sbjct: 346 KPEICRAFDLEYRGVEISSGGQREHRHDILVEQIKEKGLNPESFEFYLKAFRYGMPPHGG 405 Query: 469 GGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501 G+G ER+ L L N+R+ +FPRD +RLTP Sbjct: 406 FGLGAERLIKQMLDLPNIREVILFPRDRRRLTP 438 >1WYD-A nrPDB Length = 429 Score = 434 bits (1116), Expect = e-122, Method: Composition-based stats. Identities = 162/454 (35%), Positives = 252/454 (55%), Gaps = 31/454 (6%) Query: 48 VRDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAAN 107 + D+T + + V VH R G + F++LR + Q +V + Sbjct: 7 IADVTPEYDGKEVIWAGWVHLLRDLGGKKFIILRDKTGLGQVVVDKN----SSAFGISQE 62 Query: 108 INKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGE 167 + +ES++ V G+V+ + +ELH ++I ++S A+ LPL + Sbjct: 63 LTQESVIQVRGIVKAD-----KRAPRGIELHAEEITLLSKAKAPLPLDVS---------- 107 Query: 168 EEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAA 227 G+ + DTRL RV+DLR QAV ++QS FRETL +GF+EI TPKII++A Sbjct: 108 --GKVKADIDTRLRERVLDLRRQEMQAVIKIQSLALKAFRETLYKEGFIEIFTPKIIASA 165 Query: 228 SEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFV 287 +EGGA +F V YF A+LAQSPQLYK+ + E+VF + P +RAE+S+T HL EF+ Sbjct: 166 TEGGAQLFPVIYFGKEAFLAQSPQLYKE-LMAGVVERVFEVAPAWRAEESDTPFHLAEFI 224 Query: 288 GLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLE 347 +D+EMAF Y++VM+ + + I K ++E + E++ +N + P + P RL+ Sbjct: 225 SMDVEMAFA-DYNDVMQLLEKILHNIVKTIKEEGKEELKILNYEPP----EVKIPIKRLK 279 Query: 348 YCEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDP 407 Y EA+ +LR G + DD+ TP ++L +KE D Y + +P RPFYT Sbjct: 280 YTEAIEILRSKGYNIKFGDDIGTPELRILNEELKE----DLYFIVDWPSDARPFYTKSKS 335 Query: 408 RNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHA 467 NP+ S S+D+ + EI+SG+ R H ++L E G+ E + ++ F +G PPHA Sbjct: 336 ENPELSESFDLIYKFLEIVSGSTRNHKREVLEEALKKKGLKPESFEFFLKWFDYGMPPHA 395 Query: 468 GGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501 G G+GL R+ ++ G+ +V++ FPRD KRLTP Sbjct: 396 GFGMGLARLMVMLTGIQSVKEIVPFPRDKKRLTP 429 >3M4P-A nrPDB Length = 456 Score = 414 bits (1065), Expect = e-116, Method: Composition-based stats. Identities = 117/471 (24%), Positives = 211/471 (44%), Gaps = 31/471 (6%) Query: 37 SQEKPDRVLVRVRDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDH 96 + ++ +RD + V + H +A+ F+ LR Q ++ + Sbjct: 11 TTPVETPIVCNIRDAAGLEGKLVTFKGWAYHIRKARKTLIFVELRDGSGYCQCVIFGKEL 70 Query: 97 ASKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQQDV---ELHVQKIYVISLAEPRLP 153 + VK + +E +++ G + K D+ E+ V + VI + P Sbjct: 71 CEPEKVKL---LTRECSLEITGRLNAYAGKNHPPEIADILNLEMQVTEWKVIGES----P 123 Query: 154 LQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINK 213 + L++ + ++ + ++ NR I +R+ +Q V +L+S I FR+ + Sbjct: 124 IDLENIINKDSSIPQ----------KMQNRHIVIRSEHTQQVLQLRSEIQWYFRKYYHDN 173 Query: 214 GFVEIQTPKIISAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFR 273 F EIQ P I+ EGG+ +F + YF AYL QS QLY + I A K F + +R Sbjct: 174 HFTEIQPPTIVKTQCEGGSTLFKLQYFNEPAYLTQSSQLYLESVI-ASLGKSFCMLSSYR 232 Query: 274 AEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQF- 332 AE S T RHL E++ L+ E+ F + +++ + D + + + +I+ +N Sbjct: 233 AEQSRTVRHLAEYLHLEAELPF-ISFEDLLNHLEDLVCTVIDNVMAVHGDKIRKMNPHLK 291 Query: 333 -PCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYIL 391 P PFK + ++YC +L +D+S E+ + E F I Sbjct: 292 LPTRPFKRMTYADAIKYCNDHGILN-KDKPFEYGEDISEKPER---QMTDEIGCPIFMI- 346 Query: 392 DKYPLAVRPFYTMPDPRNPKQSNSYDMFMRG-EEILSGAQRIHDPQLLTERALHHGIDLE 450 +P ++ FY P +P + S D+ M G EI+ G+ RI + L +G++ + Sbjct: 347 -HFPSKMKAFYMSKVPGHPDLTESVDLLMPGVGEIVGGSMRIWNYDELMGAYKANGLNPD 405 Query: 451 KIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501 Y ++G+ PH G G+G+ER+ M LG ++R+ ++PR +R P Sbjct: 406 PYYWYTQQRKYGSCPHGGYGLGVERLVMWLLGEDHIRKVCLYPRYLERCEP 456 >5XIX-A nrPDB Length = 472 Score = 409 bits (1050), Expect = e-114, Method: Composition-based stats. Identities = 118/455 (25%), Positives = 201/455 (44%), Gaps = 39/455 (8%) Query: 56 ADEVVWVRARVHTSRAKGK-QCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIV 114 + V V VH R +GK FLVLR +Q ++A D + ++ ES V Sbjct: 48 RGQRVKVFGWVHRLRRQGKNLMFLVLRDGTGYLQCVLA--DELCQ--CYNGVLLSTESSV 103 Query: 115 DVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATV 174 V G++ + G EL +I LA P + Sbjct: 104 AVYGMLNLTPK--GKQAPGGHELSCDFWELIGLA-------------PAGGADNLINEES 148 Query: 175 NQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANV 234 + D +L+NR + +R + + +S + FR+ ++G+ E+ P ++ EGGA + Sbjct: 149 DVDVQLNNRHMMIRGENMSKILKARSMVTRCFRDHFFDRGYYEVTPPTLVQTQVEGGATL 208 Query: 235 FTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMA 294 F + YF A+L QS QLY + C+ A VF I +RAE S T RHL E+ ++ E Sbjct: 209 FKLDYFGEEAFLTQSSQLYLETCLPA-LGDVFCIAQSYRAEQSRTRRHLAEYTHVEAECP 267 Query: 295 FNYHYHEVMEEIADTMVQIFKGLQER-FQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALA 353 F + +++ + D + + + + + + +N F P R+ Y +A+ Sbjct: 268 FLT-FDDLLNRLEDLVCDVVDRILKSPAGSIVHELNPNFQPP----KRPFKRMNYSDAIV 322 Query: 354 MLREAGVEMGDE------DDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDP 407 L+E V+ D +D+ E+L+ + E +L ++P+ ++ FY P Sbjct: 323 WLKEHDVKKEDGTFYEFGEDIPEAPERLMTDTINEP-----ILLCRFPVEIKSFYMQRCP 377 Query: 408 RNPKQSNSYDMFMRG-EEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPH 466 + + + S D+ M EI+ G+ RI D + + GID Y D ++G PH Sbjct: 378 EDSRLTESVDVLMPNVGEIVGGSMRIFDSEEILAGYKREGIDPTPYYWYTDQRKYGTCPH 437 Query: 467 AGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501 G G+GLER L +++R ++PR +R TP Sbjct: 438 GGYGLGLERFLTWILNRYHIRDVCLYPRFVQRCTP 472 >2XGT-A nrPDB Length = 435 Score = 400 bits (1027), Expect = e-112, Method: Composition-based stats. Identities = 127/466 (27%), Positives = 217/466 (46%), Gaps = 41/466 (8%) Query: 46 VRVRDLTIQKADEVVWVRARVHTSRAKGK-QCFLVLRQQQFNVQALVAVGDHASKQMVKF 104 V++RDL ++ +E V ++ +H R +GK F +LR +Q L+ D + Sbjct: 1 VKIRDL-VKHRNERVCIKGWIHRMRRQGKSLMFFILRDGTGFLQVLLM--DKLCQTYD-- 55 Query: 105 AANINKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEA 164 A +N E V++ G +++V + G EL +I A P +D+ + EA Sbjct: 56 ALTVNTECTVEIYGAIKEVPE--GKEAPNGHELIADFWKIIGNAP---PGGIDNVLNEEA 110 Query: 165 EGEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKII 224 + D LDNR + +R + A+ RL++ RE N G+VE+ P ++ Sbjct: 111 ----------SVDKMLDNRHLVIRGENAAALLRLRAAATRAMREHFYNAGYVEVAPPTLV 160 Query: 225 SAASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLT 284 EGG+ +F + YF ++L QS QLY + CI VF I +RAE S T RHL Sbjct: 161 QTQVEGGSTLFNLDYFGEQSFLTQSSQLYLETCI-PTLGDVFCIAQSYRAEKSRTRRHLA 219 Query: 285 EFVGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQ--ERFQTEIQTVNKQFPCEPFKFLEP 342 E+ ++ E F ++ME+I + + L E + ++ +N +F P Sbjct: 220 EYAHVEAECPFIT-LDDLMEKIEELVCDTVDRLLADEEAKKLLEHINPKFQPPE----RP 274 Query: 343 TLRLEYCEALAMLREAGVE------MGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPL 396 LR+EY +A+ L+E VE +D++ E+ + + + +L+++P Sbjct: 275 FLRMEYKDAIKWLQEHNVENEFGNTFTYGEDIAEAAERFMTDTINKP-----ILLNRFPS 329 Query: 397 AVRPFYTMPDPRNPKQSNSYDMFMRG-EEILSGAQRIHDPQLLTERALHHGIDLEKIKAY 455 ++ FY D ++ + S D+ M G EI+ G+ RI L++ + ID + Y Sbjct: 330 EIKAFYMQRDAQDNTLTESVDLLMPGVGEIVGGSMRIWKFDELSKAFKNVEIDPKPYYWY 389 Query: 456 IDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501 +D +G PH G G+GLER +++R ++PR R P Sbjct: 390 LDQRLYGTCPHGGYGLGLERFICWLTNTNHIRDVCLYPRFVGRCVP 435 >1N9W-A nrPDB Length = 422 Score = 396 bits (1018), Expect = e-111, Method: Composition-based stats. Identities = 153/456 (33%), Positives = 232/456 (50%), Gaps = 36/456 (7%) Query: 46 VRVRDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFA 105 V VRDL + V + +H R G+ FL+LR + VQ + Sbjct: 3 VLVRDLKA-HVGQEVELLGFLHWRRDLGRIQFLLLRDRSGVVQVVTGGLKLPLP------ 55 Query: 106 ANINKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAE 165 ES + V G+V + + +E+ +++ V+S A P+++ Sbjct: 56 -----ESALRVRGLVVENAK-----APGGLEVQAKEVEVLSPALEPTPVEIP-------- 97 Query: 166 GEEEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIIS 225 + N DT L+ R + LR ++A ++Q+ + FR L + F EI TPK++ Sbjct: 98 ---KEEWRANPDTLLEYRYVTLRGEKARAPLKVQAALVRGFRRYLDRQDFTEIFTPKVVR 154 Query: 226 AASEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTE 285 A +EGG+ +F V YF+ AYLAQSPQLYKQ+ + FE+V+ + PV+R E+ +T RHL E Sbjct: 155 AGAEGGSGLFGVDYFEKRAYLAQSPQLYKQI-MVGVFERVYEVAPVWRMEEHHTSRHLNE 213 Query: 286 FVGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLR 345 ++ LD+EM F ++M + ++ + EI+ + +P P + R Sbjct: 214 YLSLDVEMGFIADEEDLMRLEEALLAEMLEEALNTAGDEIRLLGATWPSFP----QDIPR 269 Query: 346 LEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMP 405 L + EA +L+E + DLS E+LLG KE++ +D+ + +YP +VRPFYT Sbjct: 270 LTHAEAKRILKEE-LGYPVGQDLSEEAERLLGEYAKERWGSDWLFVTRYPRSVRPFYTY- 327 Query: 406 DPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPP 465 P + S+D+ RG EI SG QRIH + L E G+D E Y++ F++G PP Sbjct: 328 -PEEDGTTRSFDLLFRGLEITSGGQRIHRYEELLESLKAKGMDPEAFHGYLEVFKYGMPP 386 Query: 466 HAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501 H G IG ER+T LGL NVR FPRD RLTP Sbjct: 387 HGGFAIGAERLTQKLLGLPNVRYARAFPRDRHRLTP 422 >1X54-A nrPDB Length = 434 Score = 393 bits (1010), Expect = e-110, Method: Composition-based stats. Identities = 142/456 (31%), Positives = 233/456 (51%), Gaps = 32/456 (7%) Query: 49 RDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANI 108 +++ + + V + V+T+ GK+ FL +R VQA+VA + K A + Sbjct: 8 QEVKPELDGKKVRLAGWVYTNMRVGKKIFLWIRDSTGIVQAVVAKNVVGEETFEK-AKKL 66 Query: 109 NKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVI-SLAEPRLPLQLDDAVRPEAEGE 167 +ES V VEG+V+ + G E+HV+K+ VI +++E +P Sbjct: 67 GRESSVIVEGIVKADERAPGGA-----EVHVEKLEVIQAVSEFPIP-------------- 107 Query: 168 EEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAA 227 E + + LD R + +RT + A+ +++ + RE L+ G+ E+ P +++ A Sbjct: 108 -ENPEQASPELLLDYRHLHIRTPKASAIMKVKETLIMAAREWLLKDGWHEVFPPILVTGA 166 Query: 228 SEGGANVFTVSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFV 287 EGGA +F + YF AYL+QS QLY + I EKV+S+ P FRAE S T RHLTEF Sbjct: 167 VEGGATLFKLKYFDKYAYLSQSAQLYLEAAIF-GLEKVWSLTPSFRAEKSRTRRHLTEFW 225 Query: 288 GLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLE 347 L++E A+ ++M+ + + + + E + EI+ P R+ Sbjct: 226 HLELEAAWM-DLWDIMKVEEELVSYMVQRTLELRKKEIEMFRDDLTTLK-NTEPPFPRIS 283 Query: 348 YCEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDP 407 Y EA+ +L+ GV + DDL E++L E++D F++ YP ++ FY DP Sbjct: 284 YDEAIDILQSKGVNVEWGDDLGADEERVL----TEEFDRPFFVY-GYPKHIKAFYMKEDP 338 Query: 408 RNPKQSNSYDMFMR--GEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPP 465 +P++ + DM EI+ G+QR D L R L G+D + + Y+D R+G+ P Sbjct: 339 NDPRKVLASDMLAPEGYGEIIGGSQREDDYDKLLNRILEEGMDPKDYEWYLDLRRYGSVP 398 Query: 466 HAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501 H+G G+G+ER+ L L ++R ++FPR P RL P Sbjct: 399 HSGFGLGVERLVAWVLKLDHIRWAALFPRTPARLYP 434 >1LYL-A nrPDB Length = 504 Score = 383 bits (983), Expect = e-106, Method: Composition-based stats. Identities = 107/469 (22%), Positives = 189/469 (40%), Gaps = 60/469 (12%) Query: 54 QKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESI 113 + + V V R+ T R GK F+ L+ +Q VA + I Sbjct: 61 ESLNIEVSVAGRMMTRRIMGKASFVTLQDVGGRIQLYVARDSLPEGVYNDQFKKWDLGDI 120 Query: 114 VDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRAT 173 + G + K ++ +H ++ +++ A LP ++ Sbjct: 121 IGARGTLFKT-------QTGELSIHCTELRLLTKALRPLP--------------DKFHGL 159 Query: 174 VNQDTRLDNRVIDLR-TSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGA 232 +Q+ R R +DL S+ F ++S I R+ ++ +GF+E++TP + A Sbjct: 160 QDQEVRYRQRYLDLIANDKSRQTFVVRSKILAAIRQFMVARGFMEVETPMMQVIPGGASA 219 Query: 233 NVFTVSY--FKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLD 290 F + + YL +P+LY + + FE+VF I FR E + RH EF ++ Sbjct: 220 RPFITHHNALDLDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGISV-RHNPEFTMME 278 Query: 291 IEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCE 350 + MA+ YH+++E + Q + T + F F +P +L E Sbjct: 279 LYMAYA-DYHDLIELTESLFRTL-------AQEVLGTTKVTYGEHVFDFGKPFEKLTMRE 330 Query: 351 ALAMLR-----------EAGVEMGDEDDLSTPNEKLLGHLVKEKYDT-------DFYILD 392 A+ R +A + + ++ LG +V E +D + Sbjct: 331 AIKKYRPETDMADLDNFDAAKALAESIGITVEKSWGLGRIVTEIFDEVAEAHLIQPTFIT 390 Query: 393 KYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERA------LHHG 446 +YP V P D NP+ ++ ++ F+ G EI +G ++D + ER G Sbjct: 391 EYPAEVSPLARRNDV-NPEITDRFEFFIGGREIGNGFSELNDAEDQAERFQEQVNAKAAG 449 Query: 447 IDLEKI--KAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFP 493 D + Y+ + +G PP AG GIG++R+ MLF H +R +FP Sbjct: 450 DDEAMFYDEDYVTALEYGLPPTAGLGIGIDRMIMLFTNSHTIRDVILFP 498 >6CHD-A nrPDB Length = 597 Score = 378 bits (971), Expect = e-105, Method: Composition-based stats. Identities = 98/477 (20%), Positives = 185/477 (38%), Gaps = 62/477 (12%) Query: 54 QKADEVVWVRARVHTSRAKG-KQCFLVLRQQQFNVQALVAVGDH-ASKQMVKFAANINKE 111 D + V R+H RA G K F LR + +Q + ++ + ++ + + + Sbjct: 120 HLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRG 179 Query: 112 SIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGR 171 I+ V+G G + ++ + +I ++S LP Sbjct: 180 DIIGVQG-------NPGKTKKGELSIIPYEITLLSPCLHMLP--------------HLHF 218 Query: 172 ATVNQDTRLDNRVIDLR-TSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEG 230 +++TR R +DL + F ++S I R L GF+EI+TP + Sbjct: 219 GLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGA 278 Query: 231 GANVFTVSY--FKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVG 288 A F + N Y+ +P+LY +M + ++V+ IG FR E + H EF Sbjct: 279 VAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDL-THNPEFTT 337 Query: 289 LDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEY 348 + MA+ YH++ME + + K + ++ + F P R+ Sbjct: 338 CEFYMAYA-DYHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINM 396 Query: 349 CEALAM-----LREAGVEMGDE-----DDLSTPN--------------EKLLGHLVKEKY 384 E L L E + +E DD+ +KL+G ++ Sbjct: 397 VEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTC 456 Query: 385 DTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTE---- 440 +I D +P + P + + +++F+ +EI + ++DP + Sbjct: 457 INPTFICD-HPQIMSPLAKWHRSKE-GLTERFELFVMKKEICNAYTELNDPMRQRQLFEE 514 Query: 441 --RALHHGIDLEKI--KAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFP 493 +A G D + + + +G PP AG G+G++RV M +N+++ +FP Sbjct: 515 QAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 571 >1BBU-A nrPDB Length = 504 Score = 378 bits (971), Expect = e-105, Method: Composition-based stats. Identities = 103/466 (22%), Positives = 190/466 (40%), Gaps = 60/466 (12%) Query: 57 DEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDV 116 + V V R+ T R GK F+ L+ +Q VA D + + I+ Sbjct: 64 NIEVAVAGRMMTRRIMGKASFVTLQDVGGRIQLYVARDDLPEGVYNEQFKKWDLGDILGA 123 Query: 117 EGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQ 176 +G K+ ++ +H ++ +++ A LP ++ +Q Sbjct: 124 KG-------KLFKTKTGELSIHCTELRLLTKALRPLP--------------DKFHGLQDQ 162 Query: 177 DTRLDNRVIDLRTS-TSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVF 235 + R R +DL ++ S+ F+++S I R+ ++N+GF+E++TP + A F Sbjct: 163 EARYRQRYLDLISNDESRNTFKVRSQILSGIRQFMVNRGFMEVETPMMQVIPGGAAARPF 222 Query: 236 TVSY--FKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEM 293 + + YL +P+LY + + FE+VF I FR E + RH EF +++ M Sbjct: 223 ITHHNALDLDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGISV-RHNPEFTMMELYM 281 Query: 294 AFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALA 353 A+ Y +++E + Q + + F +P +L EA+ Sbjct: 282 AYA-DYKDLIELTESLFRTL-------AQDILGKTEVTYGDVTLDFGKPFEKLTMREAIK 333 Query: 354 MLR-----------EAGVEMGDEDDLSTPNEKLLGHLVKEKYDT-------DFYILDKYP 395 R ++ + + + LG +V E ++ + +YP Sbjct: 334 KYRPETDMADLDNFDSAKAIAESIGIHVEKSWGLGRIVTEIFEEVAEAHLIQPTFITEYP 393 Query: 396 LAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERA------LHHGIDL 449 V P D NP+ ++ ++ F+ G EI +G ++D + +R G D Sbjct: 394 AEVSPLARRNDV-NPEITDRFEFFIGGREIGNGFSELNDAEDQAQRFLDQVAAKDAGDDE 452 Query: 450 EKI--KAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFP 493 + Y+ + G PP AG GIG++R+ MLF H +R +FP Sbjct: 453 AMFYDEDYVTALEHGLPPTAGLGIGIDRMVMLFTNSHTIRDVILFP 498 >6ILH-A nrPDB Length = 521 Score = 377 bits (968), Expect = e-105, Method: Composition-based stats. Identities = 98/477 (20%), Positives = 184/477 (38%), Gaps = 62/477 (12%) Query: 54 QKADEVVWVRARVHTSRAKG-KQCFLVLRQQQFNVQALVAVGDH-ASKQMVKFAANINKE 111 D + V R+H RA G K F LR + +Q + ++ + ++ + + + Sbjct: 52 HLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRG 111 Query: 112 SIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGR 171 I+ V+G G + ++ + +I ++S LP Sbjct: 112 DIIGVQG-------NPGKTKKGELSIIPYEITLLSPCLHMLP--------------HLHF 150 Query: 172 ATVNQDTRLDNRVIDLR-TSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEG 230 +++TR R +DL + F ++S I R L GF+EI+TP + Sbjct: 151 GLKDKETRYRQRYLDLILNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGA 210 Query: 231 GANVFTVSY--FKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVG 288 A F + N Y+ +P+LY +M + ++V+ IG FR E + H EF Sbjct: 211 VAKPFITYHNELDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDL-THNPEFTT 269 Query: 289 LDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEY 348 + MA+ YH+ ME + + K + ++ + F P R+ Sbjct: 270 CEFYMAYA-DYHDHMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDVDFTPPFRRINM 328 Query: 349 CEALAM-----LREAGVEMGDE-----DDLSTPN--------------EKLLGHLVKEKY 384 E L L E + +E DD+ +KL+G ++ Sbjct: 329 VEELEKALGMKLPETNLFETEETRKILDDICVAKAVECPPPRTTARLLDKLVGEFLEVTC 388 Query: 385 DTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTE---- 440 +I D +P + P + + +++F+ +EI + ++DP + Sbjct: 389 INPTFICD-HPQIMSPLAKWHRSKE-GLTERFELFVMKKEICNAYTELNDPMRQRQLFEE 446 Query: 441 --RALHHGIDLEKI--KAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFP 493 +A G D + + + +G PP AG G+G++RV M +N+++ +FP Sbjct: 447 QAKAKAAGDDEAMFIDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFP 503 >4YCV-A nrPDB Length = 516 Score = 373 bits (957), Expect = e-103, Method: Composition-based stats. Identities = 94/476 (19%), Positives = 183/476 (38%), Gaps = 61/476 (12%) Query: 54 QKADEVVWVRARVHTSRAKG-KQCFLVLRQQQFNVQAL--VAVGDHASKQMVKFAANINK 110 D ++ + R+ A G K F L +Q L + +H + I + Sbjct: 52 HLEDTILNITGRIMRVSASGQKLRFFDLVGDGEKIQVLANYSFHNHEKGNFAECYDKIRR 111 Query: 111 ESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEG 170 IV + G G + ++ + ++ ++S LP++ Sbjct: 112 GDIVGIVGF-------PGKSKKGELSIFPKETILLSACLHMLPMK--------------- 149 Query: 171 RATVNQDTRLDNRVIDL-RTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASE 229 + + R R +DL +S+ F ++ I + R L +GF E++TP + A Sbjct: 150 YGLKDTEIRYRQRYLDLLINESSRHTFVTRTKIINFLRNFLNERGFFEVETPMMNLIAGG 209 Query: 230 GGANVFTVSY--FKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFV 287 A F + + YL + +L +M I +KV+ IG VFR E + + H EF Sbjct: 210 ANARPFITHHNDLDLDLYLRIATELPLKMLIVGGIDKVYEIGKVFRNEGID-NTHNPEFT 268 Query: 288 GLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLE 347 + A+ Y+++++ D Q+ L ++ + F P ++ Sbjct: 269 SCEFYWAYA-DYNDLIKWSEDFFSQLVYHLFGTYKISYNKDGPENQPIEIDFTPPYPKVS 327 Query: 348 YCEALAMLR--------------EAGVEMGDEDDLSTPN--------EKLLGHLVKEKYD 385 E + + E + + E + PN ++L H ++ KY+ Sbjct: 328 IVEEIEKVTNTILEQPFDSNETIEKMINIIKEHKIELPNPPTAAKLLDQLASHFIENKYN 387 Query: 386 TDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHH 445 + + ++P + P + P + +MF+ G+E+L+ ++DP E Sbjct: 388 DKPFFIVEHPQIMSPLAKYHRTK-PGLTERLEMFICGKEVLNAYTELNDPFKQKECFKLQ 446 Query: 446 GIDLEK--------IKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFP 493 D EK A+ S +G PP G G+G++R+TM ++++ +FP Sbjct: 447 QKDREKGDTEAAQLDSAFCTSLEYGLPPTGGLGLGIDRITMFLTNKNSIKDVILFP 502 >4EX5-A nrPDB Length = 529 Score = 373 bits (957), Expect = e-103, Method: Composition-based stats. Identities = 97/468 (20%), Positives = 178/468 (38%), Gaps = 65/468 (13%) Query: 59 VVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEG 118 V + R+ R GK F ++ +Q V D ++ F + IV G Sbjct: 88 EVAIAGRMMLKRVMGKASFATVQDGSGQIQFFVTPADVGAETYDAFK-KWDLGDIVAARG 146 Query: 119 VVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDT 178 V+ + N+ ++ + ++ +++ A LP ++ +Q+T Sbjct: 147 VLFRTNK-------GELSVKCTQLRLLAKALRPLP--------------DKFHGLADQET 185 Query: 179 RLDNRVIDLR-TSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTV 237 R R +DL T ++ FR ++ R+ + + F+E++TP + A F Sbjct: 186 RYRQRYVDLIVTPETRTTFRARTKAIASIRKFMGDADFMEVETPMLHPIPGGAAAKPFVT 245 Query: 238 SY--FKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAF 295 + +L +P+LY + I FE+VF I FR E + RH EF ++ A+ Sbjct: 246 HHNALDMEMFLRIAPELYLKRLIVGGFERVFEINRNFRNEGV-SPRHNPEFTMMEFYAAY 304 Query: 296 NYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAM- 354 Y +M+ +++ + T Q+ +P RL +A+ Sbjct: 305 -TDYRWLMDFTERL-------IRQAAVDALGTATIQYQGRELDLAQPFHRLTITQAIQKY 356 Query: 355 ------------------LREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFY---ILDK 393 L+ GV++ L+ L L +E + + + Sbjct: 357 APSYTDGQLSDDAFLRSELKRLGVDVTQPAFLNAGIGALQLALFEETAEAQLWEPTFIID 416 Query: 394 YPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALH-----HGID 448 YP+ V P D + +++F+ G EI +G ++DP+ R D Sbjct: 417 YPIEVSPLARESDT-VAGITERFELFITGREIANGFSELNDPEDQAARFKKQVEQKDAGD 475 Query: 449 LEKI---KAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFP 493 E + YI + +G PP G GIG++R+ ML +R +FP Sbjct: 476 EEAMFFDADYIRALEYGMPPTGGCGIGIDRLVMLLTDSPTIRDVLLFP 523 >3A74-A nrPDB Length = 493 Score = 370 bits (950), Expect = e-103, Method: Composition-based stats. Identities = 108/515 (20%), Positives = 203/515 (39%), Gaps = 65/515 (12%) Query: 15 REIMDAAEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADE---VVWVRARVHTSRA 71 RE + E+ + +G + K + + DL+ ++ +E V V R+ T R Sbjct: 13 REKLKKIEELGVDPFGKR--FERTHKAEELFELYGDLSKEELEEQQIEVAVAGRIMTKRG 70 Query: 72 KGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRKVNQKIGSCT 131 GK F ++ +Q V D +Q F + + IV V G + K Sbjct: 71 MGKAGFAHIQDVTGQIQIYVRQDDVGEQQYELFKIS-DLGDIVGVRGTMFKTK------- 122 Query: 132 QQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLR-TS 190 ++ + V ++ A LP E+ + + R R +DL Sbjct: 123 VGELSIKVSSYEFLTKALRPLP--------------EKYHGLKDIEQRYRQRYLDLIMNP 168 Query: 191 TSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSY--FKNNAYLAQ 248 S+ F +S I R L + G++E++TP + + A A F + Y+ Sbjct: 169 ESKKTFITRSLIIQSMRRYLDSHGYLEVETPMMHAVAGGAAARPFITHHNALDMTLYMRI 228 Query: 249 SPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIAD 308 + +L+ + I EKV+ IG VFR E +T RH EF L++ A+ + ++M+ + Sbjct: 229 AIELHLKRLIVGGLEKVYEIGRVFRNEGIST-RHNPEFTMLELYEAYA-DFRDIMKLTEN 286 Query: 309 TMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALA----------MLREA 358 + I + + T Q+ RL +A+ M E Sbjct: 287 LIAHIATEV-------LGTTKIQYGEHLVDLTPEWRRLHMVDAIKEYVGVDFWRQMSDEE 339 Query: 359 GVEMGDEDDLSTPNEKLLGHLVKEKYDT-------DFYILDKYPLAVRPFYTMPDPRNPK 411 E+ E + GH+V E ++ + +P+ + P P +P+ Sbjct: 340 ARELAKEHGVEVAPHMTFGHIVNEFFEQKVEDKLIQPTFIYGHPVEISPLAKKN-PDDPR 398 Query: 412 QSNSYDMFMRGEEILSGAQRIHDP--------QLLTERALHHGIDLEKIKAYIDSFRFGA 463 ++ +++F+ G E + ++DP + L ER + E + ++++ +G Sbjct: 399 FTDRFELFIVGREHANAFTELNDPIDQRQRFEEQLKEREQGNDEAHEMDEDFLEALEYGM 458 Query: 464 PPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKR 498 PP G GIG++R+ ML ++R +FP+ + Sbjct: 459 PPTGGLGIGVDRLVMLLTNSPSIRDVLLFPQMRHK 493 >5ZG8-A nrPDB Length = 438 Score = 364 bits (935), Expect = e-101, Method: Composition-based stats. Identities = 135/461 (29%), Positives = 215/461 (46%), Gaps = 37/461 (8%) Query: 50 DLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANIN 109 D + D+ V +R ++ R+KGK FL+LR +QA V G+ + + + A ++ Sbjct: 6 DEIARHVDQEVELRGWLYQRRSKGKIHFLILRDGTGFLQATVVQGEV-PEAVFREADHLP 64 Query: 110 KESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEE 169 +E+ + V G VR+ + EL V+ + V+S + P+ Sbjct: 65 QETALRVWGRVREDRR-----APGGFELAVRDLQVVSRPQGEYPI--------------- 104 Query: 170 GRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASE 229 G D +D+R + LR AV R++ + E +GF+ P + +A E Sbjct: 105 GPKEHGIDFLMDHRHLWLRHRRPFAVMRIRDELERAIHEFFGERGFLRFDAPILTPSAVE 164 Query: 230 GGANVFTVSYFK-NNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVG 288 G +F V F AYL+QS QLY + A F KV++ GP FRAE S T RHL EF Sbjct: 165 GTTELFEVELFDGEKAYLSQSGQLYAEAGALA-FAKVYTFGPTFRAERSKTRRHLLEFWM 223 Query: 289 LDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEY 348 ++ E+AF H M + + + + ER E++ + + RL Y Sbjct: 224 VEPEVAFMTHEEN-MALQEELVSFLVARVLERRSRELEMLGRDPKALEPAAEGHYPRLTY 282 Query: 349 CEALAMLREAGVE------MGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFY 402 EA+A++ E + +D P+E L ++D ++ ++YP ++ FY Sbjct: 283 KEAVALVNRIAQEDPEVPPLPYGEDFGAPHEAALSR----RFDRPVFV-ERYPARIKAFY 337 Query: 403 TMPDPRNPKQSNSYDMFMR--GEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFR 460 PDP +P+ + D+ EI+ G+QRIHD +LL + G+ E Y+D R Sbjct: 338 MEPDPEDPELVLNDDLLAPEGYGEIIGGSQRIHDLELLRRKIQEFGLPEEVYDWYLDLRR 397 Query: 461 FGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501 FG+ PH+G G+GLER GL +VR+ FPR R+ P Sbjct: 398 FGSVPHSGFGLGLERTVAWICGLAHVREAIPFPRMYTRMRP 438 >5ELO-A nrPDB Length = 535 Score = 362 bits (929), Expect = e-100, Method: Composition-based stats. Identities = 96/494 (19%), Positives = 193/494 (39%), Gaps = 64/494 (12%) Query: 37 SQEKPDRVLVRVRDLTIQKADEVVWVRARVHTSRAKG-KQCFLVLRQQQFNVQAL--VAV 93 S V + I K D + + RV + R+ K F + ++ VQ + + Sbjct: 51 SLPAYALKYGNVENGYIDK-DTTLSLSGRVTSIRSSSSKLIFYDIFCEEQKVQIIANIME 109 Query: 94 GDHASKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLP 153 D ++ + + I + +V G G + ++ L + + ++S LP Sbjct: 110 HDISTGEFSVSHSEIRRGDVVGFTGF-------PGKSKRGELSLFSKSVVLLSPCYHMLP 162 Query: 154 LQLDDAVRPEAEGEEEGRATVNQDTRLDNRVIDLR-TSTSQAVFRLQSGICHLFRETLIN 212 + +Q+ R R +DL S+ VF+L+S R Sbjct: 163 TAIS--------------GLKDQEVRYRQRYLDLMLNEESRKVFKLRSRAIKYIRNYFDR 208 Query: 213 KGFVEIQTPKIISAASEGGANVFTVSY--FKNNAYLAQSPQLYKQMCICADFEKVFSIGP 270 GF+E++TP + A F + + Y+ +P+LY + I +KV+ IG Sbjct: 209 LGFLEVETPMLNMIYGGAAARPFITYHNELETQLYMRIAPELYLKQLIVGGLDKVYEIGK 268 Query: 271 VFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNK 330 FR E + H EF ++ MA+ Y+++M+ + + + + + Sbjct: 269 NFRNEGIDL-THNPEFTAMEFYMAYA-DYYDLMDLTEELISGLVLEIHGSLKIPYHPDGP 326 Query: 331 QFPCEPFKFLEPTLRLEYCEALA-----MLR---------EAGVEMGDEDDLSTPN---- 372 + C F P R + E + L+ + VEM ++ ++ P+ Sbjct: 327 EGKCIEIDFTTPWKRFSFVEEIESGLGEKLKRPLDSQENIDFMVEMCEKHEIELPHPRTA 386 Query: 373 ----EKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSG 428 +KL GH V+ K +I+D +P + P P+ + +++F+ G+E+ + Sbjct: 387 AKLLDKLAGHFVETKCTNPSFIID-HPQTMSPLAKW-HREKPEMTERFELFVLGKELCNA 444 Query: 429 AQRIHDPQLLTERALHHGIDLEK---------IKAYIDSFRFGAPPHAGGGIGLERVTML 479 +++P L + D + + + + G PP G G+G++R+ M Sbjct: 445 YTELNEP-LQQRKFFEQQADAKASGDVEACPIDETFCLALEHGLPPTGGWGLGIDRLIMF 503 Query: 480 FLGLHNVRQTSMFP 493 +N+++ +FP Sbjct: 504 LADKNNIKEVILFP 517 >5HGQ-A nrPDB Length = 524 Score = 354 bits (907), Expect = 7e-98, Method: Composition-based stats. Identities = 96/474 (20%), Positives = 173/474 (36%), Gaps = 61/474 (12%) Query: 57 DEVVWVRARVHTSRAKG-KQCFLVLRQQQFNVQALVAVGDH-ASKQMVKFAANINKESIV 114 D V V RV + R G K F L + +Q L H + I + I+ Sbjct: 57 DIVQSVAGRVFSKRESGGKLIFYDLHGEGTRLQVLANARFHSGDEAFDNLHDRIKRGDII 116 Query: 115 DVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATV 174 V G ++ + +I ++ LP Sbjct: 117 GVNGY-------PARSKSGELSIIPYEIIQLTPCLHMLP--------------HTHFGLK 155 Query: 175 NQDTRLDNRVIDLR-TSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGAN 233 NQ+TR R +DL + F +S + R L N GF+E++TP + A A Sbjct: 156 NQETRYRMRYLDLIMNPDVKNRFVTRSRMISFLRRYLDNLGFLEVETPMMNLIAGGATAK 215 Query: 234 VFTVSY--FKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDI 291 F + + YL +P+LY +M + ++V+ IG VFR E + H EF + Sbjct: 216 PFITHHNDLDMDLYLRVAPELYLKMLVVGGIDRVYEIGRVFRNEGID-QTHNPEFTSCEF 274 Query: 292 EMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNK-QFPCEPFKFLEPTLRLEY-- 348 MA+ Y ++M+ D + ++ + ++ + + P F P ++ Sbjct: 275 YMAYA-DYEDLMKITEDMLARMVYYMHGTYKIQYHPNGIVENPVYEVDFTPPFRKVNIYD 333 Query: 349 ------------------CEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFY- 389 EA + VE E +LL L+ E + F Sbjct: 334 GLQEKLGIQFPPADTLDTDEANKFFDKLAVENNVECPAPRTTARLLDKLIGEFLEPTFIS 393 Query: 390 --ILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDP--------QLLT 439 L +P + P P + +++F+ +EI++ ++DP + Sbjct: 394 PTFLTGHPQIMSPLAKW-HRSIPGLTERFELFVVTKEIVNAYTELNDPLTQRLRFDEQAK 452 Query: 440 ERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFP 493 ++ + Y + +G PP AG G+G++R+ M+ +N+++ FP Sbjct: 453 QKQAGDDEAQNIDENYCTALEYGLPPTAGWGMGIDRLAMILTDSNNIKEVLFFP 506 >6AQG-A nrPDB Length = 506 Score = 347 bits (891), Expect = 4e-96, Method: Composition-based stats. Identities = 111/517 (21%), Positives = 215/517 (41%), Gaps = 54/517 (10%) Query: 4 ASASRKSQEKPREIMDAAEDYAKERYGISSMIQSQEKP-DRVLVRVRDLTIQKADE-VVW 61 +SA E+ R D E Y + + + DL A E +V Sbjct: 10 SSAESNIPEQFRIRRDKRARLLAEGYDPYPVAIERTHTLAEIRATYADLPTDSATEDIVG 69 Query: 62 VRARVHTSRAKGKQCFLVLRQQQF-NVQALVAVGDHASKQMVKFAANINKESIVDVEGVV 120 V RV +R GK CF L+ +QA++++ + + + ++ A+++ +V V G V Sbjct: 70 VAGRVVFARNTGKLCFATLQDGDGTQLQAMISLDEVGRESLDRWKADVDIGDVVYVHGTV 129 Query: 121 RKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTRL 180 + ++ + + + A LP+ +++++R+ Sbjct: 130 ISSRR-------GELSVLADSWRMAAKALRPLPV---------------AHKEMSEESRV 167 Query: 181 DNRVIDLR-TSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVS- 238 R +DL ++ V R + + R L +GF+E++TP + + A A F Sbjct: 168 RQRYVDLIVRPQAREVARQRIAVIRAVRNALERRGFLEVETPMLQTLAGGAAARPFVTHS 227 Query: 239 -YFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNY 297 + YL +P+L+ + CI F++VF + VFR E S++ H EF L+ + Sbjct: 228 NALDIDLYLRIAPELFLKRCIVGGFDRVFELNRVFRNEGSDS-THSPEFSMLETYQTYGT 286 Query: 298 H------YHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTL--RLEYC 349 + E+++E+AD + + L + + E + L L ++ Sbjct: 287 YDDSALITRELIQEVADEAIGT-RQLSMPDGSVYDIDGEWATMEMYSSLSEALGEQITPE 345 Query: 350 EALAMLREAGVEMGDEDDLSTPN-----EKLLGHLVKEKYDTDFYILDKYPLAVRPFYTM 404 +A LR+ + E D S E+L H V K ++ D +P+ P T Sbjct: 346 TTVARLRDIASGLDVEIDNSVFGHGKLVEELWEHAVGNKLTAPTFVKD-FPVETTPL-TR 403 Query: 405 PDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERA--------LHHGIDLEKIKAYI 456 P + +D+++RG E+ +G ++DP + +R ++ + ++ Sbjct: 404 QHRSIPGVTEKWDLYVRGVELATGYSELNDPVVQRDRFADQARAAAAGDDEAMQLDEDFL 463 Query: 457 DSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFP 493 + +G PP G G+G++R+ M GL ++R+T +FP Sbjct: 464 TALEYGMPPCTGTGMGIDRLLMCLTGL-SIRETVLFP 499 >6NRZ-A nrPDB Length = 534 Score = 326 bits (835), Expect = 2e-89, Method: Composition-based stats. Identities = 87/490 (17%), Positives = 187/490 (38%), Gaps = 66/490 (13%) Query: 49 RDLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVG---------DHASK 99 + +K V R+ R+ GK F + +Q + D Sbjct: 64 SEAAFRKETPKVRFAGRLVLFRSMGKNAFGQILDNDAKIQVMFNRDFSAVAGLAADAGIS 123 Query: 100 QMVKFAANINKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDA 159 + ++ I+ +EG + + ++ + V+ + ++ + LP Sbjct: 124 PIKFIEKKLDLGDILGLEGYLFFTH-------SGELTVLVETVTLLCKSLISLP------ 170 Query: 160 VRPEAEGEEEGRATVNQDTRLDNRVIDLRTSTS-QAVFRLQSGICHLFRETLINKGFVEI 218 ++ +++ R R DL +S + F +S I L RE + + F+E+ Sbjct: 171 --------DKHAGLADKEIRYRKRWADLISSEDVRKTFLTRSRILKLIREYMDQQSFLEV 222 Query: 219 QTPKIISAASEGGANVFTV--SYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAED 276 +TP + + A F +L S ++ + + +V+ IG VFR E Sbjct: 223 ETPILQTVYGGAEATPFVTTLQALHAEMFLRISLEIALKKLLVGGMSRVYEIGKVFRNEG 282 Query: 277 SNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEP 336 + H EF ++ A+ + Y++VM+ + + + I + L +T++Q + + + Sbjct: 283 ID-RTHNPEFTMIEAYAAY-WDYNDVMKCVENLVEYIVRALNNG-ETQVQYSHLKSGPQV 339 Query: 337 FKFLEPTLRLEYCEALAMLREAGVEMGDEDDL--------------------STPNEKLL 376 F P +R+ E++++ V++ + +L L Sbjct: 340 VDFKAPWIRMTMKESISVYGGVDVDLHADHELRKILETQTSLPEKTYVHASRGELIALLF 399 Query: 377 GHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDP- 435 LV +K +I D +PL P + ++ F G+E+ + ++DP Sbjct: 400 DELVCDKLIAPHHITD-HPLETTPLCKTLRSGDETLVERFESFCLGKELCNAYSELNDPL 458 Query: 436 ---QLLTERALHHGIDLEK-----IKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVR 487 +LL E+ ++ + + ++++ G PP G GIG++R+ M+ ++R Sbjct: 459 QQRKLLEEQMRKKALNPDSEYHPIDEEFLEALCQGMPPAGGFGIGIDRLVMMLTDAASIR 518 Query: 488 QTSMFPRDPK 497 FP + Sbjct: 519 DVLFFPVMRR 528 >6AQH-A nrPDB Length = 508 Score = 317 bits (811), Expect = 9e-87, Method: Composition-based stats. Identities = 101/476 (21%), Positives = 197/476 (41%), Gaps = 54/476 (11%) Query: 50 DLTIQ-KADEVVWVRARVHTSRAKGKQCFLVLRQQQF-NVQALVAVGDHASKQMVKFAAN 107 DL + + E+V V RV +R GK CF L++ +QA++++ + + + + Sbjct: 60 DLPVDARTGEIVGVTGRVVFARNSGKLCFATLQEGDGTQLQAMISLAEVGQEALDNWKTY 119 Query: 108 INKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGE 167 ++ IV V G V + ++ + + + A LP+ Sbjct: 120 VDIGDIVFVHGEVITSKR-------GELSVLADSWQMAAKALRPLPV------------- 159 Query: 168 EEGRATVNQDTRLDNRVIDLR-TSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISA 226 +++++R+ R +DL ++ V R + + R L +GF+E++TP + + Sbjct: 160 --AHKEMSEESRVRQRYVDLIVRDQARKVARQRIAVMRAIRSALERRGFLEVETPMLQTL 217 Query: 227 ASEGGANVFTVS--YFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLT 284 A A F YL +P+L+ + C+ FE+VF + VFR E +++ H Sbjct: 218 AGGAAARPFVTHSNALDTELYLRIAPELFLKRCLVGGFERVFELNRVFRNEGADS-THSP 276 Query: 285 EFVGLDIEMAFNYH------YHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFK 338 EFV L+ A+ + E+++E+AD + + + T + + + Sbjct: 277 EFVMLETYQAYGTYDDSAVVTRELIQEVADEAIGT-RQVPLPDGTVYDLDGEWESIQMYP 335 Query: 339 FLEPTLRLEYCEAL------AMLREAGVEMGDEDDLSTPN--EKLLGHLVKEKYDTDFYI 390 L L E A+ G+++ + E+L H V K ++ Sbjct: 336 SLSEALGEEITPDTPAETLWAIADRLGLDIPRDRGYGHGKLVEELWEHTVGAKLWAPTFV 395 Query: 391 LDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLE 450 D +P+ P T P + +D+++R E+ +G + DP + ER Sbjct: 396 KD-FPVETTPL-TRSHRSIPGVTEKWDLYVRRIELATGYSELTDPIIQRERFEAQARAAA 453 Query: 451 K--------IKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKR 498 + ++ + +G PP G G+G++R+ M GL ++R+T +FP R Sbjct: 454 AGDDEAMALDEDFLAALEYGMPPSTGTGMGIDRLMMTLTGL-SIRETVLFPIVKPR 508 >5W25-A nrPDB Length = 616 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 75/295 (25%), Positives = 120/295 (40%), Gaps = 23/295 (7%) Query: 56 ADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVD 115 A + V + V R G F+ LR Q + D +++ A + E V Sbjct: 37 AGQQVTLAGWVARRRDHGGVIFIDLRDASGIAQVVF--RDPQDTEVLAQAHRLRAEFCVS 94 Query: 116 VEGVV--RKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRAT 173 V GVV R ++E++ + V+ LP QLD+ Sbjct: 95 VAGVVEIRPEGNANPEIATGEIEVNATSLTVLGEC-APLPFQLDEP-------------- 139 Query: 174 VNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGAN 233 ++ RL R +DLR A RL+S + R L FVEI+TP I + EG + Sbjct: 140 AGEELRLKYRYLDLRRDDPAAAIRLRSRVNAAARAVLARHDFVEIETPTITRSTPEGARD 199 Query: 234 VFTVSYFKNNAY--LAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDI 291 + ++ L QSPQL+KQ+ + A E+ + I +R ED R EF LD+ Sbjct: 200 FLVPARLHPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQ-PEFTQLDM 258 Query: 292 EMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRL 346 EM+F +++ + + +++ + R T I + F +P LR Sbjct: 259 EMSF-VDAEDIIAISEEVLTELWALIGYRIPTPIPRIGYAEAMRRFGTDKPDLRF 312 Score = 118 bits (295), Expect = 7e-27, Method: Composition-based stats. Identities = 30/94 (31%), Positives = 47/94 (50%), Gaps = 4/94 (4%) Query: 412 QSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGID----LEKIKAYIDSFRFGAPPHA 467 +++YD+ G EI G+ RIH + G+D EK +++F FGAPPH Sbjct: 495 LADAYDIVCNGHEIGGGSVRIHRRDIQERVFAVMGLDKAEAEEKFGFLLEAFMFGAPPHG 554 Query: 468 GGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501 G G +R T L G+ ++R+ FP+ + P Sbjct: 555 GIAFGWDRTTALLAGMDSIREVIAFPKTGGGVDP 588 >4RMF-A nrPDB Length = 609 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 75/313 (23%), Positives = 125/313 (39%), Gaps = 28/313 (8%) Query: 51 LTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINK 110 L A + V + V R G F+ LR Q + GD ++ A + Sbjct: 10 LRPADAGQTVTLAGWVARRRDHGGVIFIDLRDASGVSQVVFREGD-----VLAAAHRLRA 64 Query: 111 ESIVDVEGVV--RKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEE 168 E V V GVV R + +E++ ++ V+ + LP QLD Sbjct: 65 EFCVAVTGVVEVRPEGNENPEIPTGQIEVNATELTVLGES-APLPFQLD----------- 112 Query: 169 EGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAAS 228 ++ RL R +DLR RL+S + R L FVEI+TP + + Sbjct: 113 ---EQAGEEARLKYRYLDLRREGPGNALRLRSKVNAAARSVLAEHDFVEIETPTLTRSTP 169 Query: 229 EGGANVFTVSYFKNNAY--LAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEF 286 EG + + + ++ L QSPQL+KQ+ + A E+ + I +R ED R EF Sbjct: 170 EGARDFLVPARLQPGSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQ-PEF 228 Query: 287 VGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLR- 345 LD+EM+F +V+ + ++ + + ++ + F +P LR Sbjct: 229 TQLDMEMSFVE-ADDVIAISEQVLKAVWATIGYDLPLPLPRISYEEAMRRFGSDKPDLRF 287 Query: 346 -LEYCEALAMLRE 357 +E E ++ Sbjct: 288 GIELVECTEYFKD 300 Score = 122 bits (306), Expect = 3e-28, Method: Composition-based stats. Identities = 35/112 (31%), Positives = 53/112 (47%), Gaps = 6/112 (5%) Query: 396 LAVRPFYTMPDPRNPK--QSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGID----L 449 A +P +P S++YD+ G EI G+ RIH + GID Sbjct: 452 TAPKPDSVDTFDSDPGNALSDAYDIVCNGNEIGGGSIRIHRRDIQERVFAMMGIDHDEAQ 511 Query: 450 EKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKRLTP 501 EK +D+F +GAPPH G G +R+T L G+ ++R+ FP+ + P Sbjct: 512 EKFGFLLDAFSYGAPPHGGIAFGWDRITALLAGVDSIREVIAFPKSGGGVDP 563 >4WJ3-M nrPDB Length = 599 Score = 242 bits (617), Expect = 3e-64, Method: Composition-based stats. Identities = 77/312 (24%), Positives = 134/312 (42%), Gaps = 24/312 (7%) Query: 57 DEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDV 116 + V + VH R G FL +R ++ Q + D + A + E +V + Sbjct: 24 GQEVTLCGWVHRRRDHGGVIFLDVRDREGLAQVVF---DPDRAETFAKADRVRSEFVVKI 80 Query: 117 EGVVRKVNQK--IGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATV 174 G VR + + +E+ ++ V++ AE P LD+ + V Sbjct: 81 TGKVRLRPEGARNPNMASGSIEVLGYELEVLNQAETP-PFPLDE------------YSDV 127 Query: 175 NQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANV 234 ++TRL R IDLR A +L++ I R L + GF++++TP + EG + Sbjct: 128 GEETRLRYRFIDLRRPEMAAKLKLRARITSSIRRYLDDNGFLDVETPILGRPTPEGARDY 187 Query: 235 FTV--SYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIE 292 +Y + L QSPQL+KQ+ + A F++ + I FR ED R EF +DIE Sbjct: 188 LVPSRTYPGHFFALPQSPQLFKQLLMVAGFDRYYQIAKCFRDEDLRADRQ-PEFTQIDIE 246 Query: 293 MAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLR--LEYCE 350 +F +++ + Q+FK + + E + + + +P LR LE + Sbjct: 247 TSFL-DESDIIGITEKMVRQLFKEVLDVEFDEFPHMPFEEAMRRYGSDKPDLRIPLELVD 305 Query: 351 ALAMLREAGVEM 362 L+E ++ Sbjct: 306 VADQLKEVEFKV 317 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 45/159 (28%), Positives = 64/159 (40%), Gaps = 17/159 (10%) Query: 343 TLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFY 402 LR++ L +L M D E G L F P + Sbjct: 419 ALRIKVGHDLKLLTREWAPM-WVVDFPMFEENDDGSL--SALHHPFTSPKCTPAELEA-- 473 Query: 403 TMPDPRNPK--QSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDL----EKIKAYI 456 NP S +YDM + G E+ G+ RIHD + GID EK + Sbjct: 474 ------NPGAALSRAYDMVLNGTELGGGSIRIHDKSMQQAVFRVLGIDEAEQEEKFGFLL 527 Query: 457 DSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRD 495 D+ ++GAPPH G GL+R+ ML G ++R+ FP+ Sbjct: 528 DALKYGAPPHGGLAFGLDRLVMLMTGASSIREVIAFPKT 566 >1IL2-A nrPDB Length = 590 Score = 240 bits (613), Expect = 9e-64, Method: Composition-based stats. Identities = 73/316 (23%), Positives = 131/316 (41%), Gaps = 30/316 (9%) Query: 51 LTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINK 110 L + + V + V+ R G F+ +R ++ VQ D +K A+ + Sbjct: 9 LRLSHVGQQVTLCGWVNRRRDLGSLIFIDMRDREGIVQVFF---DPDRADALKLASELRN 65 Query: 111 ESIVDVEGVVRKVNQKIGS--CTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEE 168 E + V G VR ++K + ++E+ + +I+ A+ LPL + Sbjct: 66 EFCIQVTGTVRARDEKNINRDMATGEIEVLASSLTIINRADV-LPLDSNHVN-------- 116 Query: 169 EGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAAS 228 ++ RL R +DLR + ++ I L R + + GF++I+TP + A Sbjct: 117 ------TEEARLKYRYLDLRRPEMAQRLKTRAKITSLVRRFMDDHGFLDIETPMLTKATP 170 Query: 229 EGGANVFTVSYFKNNAY--LAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEF 286 EG + S + L QSPQL+KQ+ + + F++ + I FR ED R EF Sbjct: 171 EGARDYLVPSRVHKGKFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQ-PEF 229 Query: 287 VGLDIEMAFNY--HYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTL 344 +D+E +F EVME + + KG+ + + + +P L Sbjct: 230 TQIDVETSFMTAPQVREVMEALVRHLWLEVKGVDLG---DFPVMTFAEAERRYGSDKPDL 286 Query: 345 R--LEYCEALAMLREA 358 R +E + +L+ Sbjct: 287 RNPMELTDVADLLKSV 302 >3G1Z-A nrPDB Length = 326 Score = 228 bits (580), Expect = 6e-60, Method: Composition-based stats. Identities = 65/324 (20%), Positives = 127/324 (39%), Gaps = 34/324 (10%) Query: 195 VFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYF--------KNNAYL 246 ++ I R ++G +E++TP +S A+ ++F N YL Sbjct: 16 NLLKRAAIMAEIRRFFADRGVLEVETP-CMSQATVTDIHLFPFETRFVGPGHSQGINLYL 74 Query: 247 AQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEI 306 SP+ + + + A VF + FR E+ H H EF L+ +Y + +M E+ Sbjct: 75 MTSPEYHMKRLLAAGCGPVFQLCRSFRNEEMGRH-HNPEFTMLEWYRP-HYDMYRLMNEV 132 Query: 307 ADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDED 366 D + Q+ + Q + +P + LR EA A L + + E+ Sbjct: 133 DDLLQQVLDCQPAESLSYQQAFQRHLEIDPLSADKTQLR----EAAAKLDLSNI-ADTEE 187 Query: 367 DLSTPNEKLLG-----HLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMR 421 D T + L H+ KEK + +P + + + + + ++++ + Sbjct: 188 DRDTLLQLLFTMGVEPHIGKEKPT----FIYHFPAS-QASLAQISTEDHRVAERFEVYYK 242 Query: 422 GEEILSGAQRIHDPQLLTERA-------LHHGIDLEK-IKAYIDSFRFGAPPHAGGGIGL 473 G E+ +G + D + +R G+ + + +D+ G P +G +G+ Sbjct: 243 GIELANGFHELTDAREQQQRFEQDNRKRAARGLPQQPIDQNLLDALAAGLPDCSGVALGV 302 Query: 474 ERVTMLFLGLHNVRQTSMFPRDPK 497 +R+ ML LG ++ F D Sbjct: 303 DRLVMLALGAESLADVIAFTVDRA 326 >4UP8-A nrPDB Length = 777 Score = 219 bits (557), Expect = 3e-57, Method: Composition-based stats. Identities = 69/348 (19%), Positives = 128/348 (36%), Gaps = 38/348 (10%) Query: 51 LTIQKADEVVWVRARVHTSRAKGKQC-FLVLRQQQFNVQALVAVGD-HASKQMVKFAANI 108 Q +D++V V RV + R+ F+ L Q +Q ++ + V I Sbjct: 53 EKSQVSDDIVSVAGRVLSKRSSSSALMFIDLHDSQTKLQIMLNKSAYENKEDFVSLTKMI 112 Query: 109 NKESIVDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEE 168 + I G ++ L ++S LP Sbjct: 113 YRGDICGFTG-------HPTRTKTGELSLIPISGMILSPCLHMLP--------------S 151 Query: 169 EGRATVNQDTRLDNRVIDLR-TSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAA 227 +Q+TR R +DL S F L++ + R+ L +KGF+E++TP + + Sbjct: 152 MHYGLGDQETRFRKRYLDLIVNPESVKNFVLRTKVVKAVRKYLDDKGFLEVETPILNTIP 211 Query: 228 SEGGANVFTVSY--FKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTE 285 A F + Y+ +P+LY + + +V+ IG +FR E + H E Sbjct: 212 GGATARPFITHHNQLDIQMYMRIAPELYLKELVVGGINRVYEIGRLFRNEGID-QTHNPE 270 Query: 286 FVGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQE-----RFQTEIQTVNKQFPCEPFK-- 338 F + MA+ Y+++M+ + + + K + + + +N + + + Sbjct: 271 FTTCEFYMAYA-DYNDIMKMTEELLGNMVKDITGGSTKLEIKDRLMDINNEEDIKMLEKF 329 Query: 339 FLEPTLR-LEYCEALAMLREAGVEMGDEDD--LSTPNEKLLGHLVKEK 383 F EP R E ++ + E+ D +KL V EK Sbjct: 330 FKEPIPRPFNSAECSKVIEKHCTELNYYYDGNNEKAMKKLFADFVTEK 377 >1EFW-A nrPDB Length = 580 Score = 218 bits (554), Expect = 6e-57, Method: Composition-based stats. Identities = 82/318 (25%), Positives = 134/318 (42%), Gaps = 18/318 (5%) Query: 55 KADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIV 114 E V + V+ R G FL LR ++ VQ + H + A + E +V Sbjct: 14 HVGEEVVLEGWVNRRRDLGGLIFLDLRDREGLVQLVA----HPASPAYATAERVRPEWVV 69 Query: 115 DVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATV 174 +G+VR + VE+ + + V++ A+ P +D R E E E Sbjct: 70 RAKGLVRLRPEPNPRLATGRVEVELSALEVLAEAKTP-PFPVDAGWRGEEEKEASEE--- 125 Query: 175 NQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANV 234 RL R +DLR Q RL+ + + L +GFV+++TP + + EG + Sbjct: 126 ---LRLKYRYLDLRRRRMQENLRLRHRVIKAIWDFLDREGFVQVETPFLTKSTPEGARDF 182 Query: 235 FTVSYFKNNAY--LAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIE 292 + + L QSPQL+KQM + A ++ F I FR ED R +F LD+E Sbjct: 183 LVPYRHEPGLFYALPQSPQLFKQMLMVAGLDRYFQIARCFRDEDLRADRQ-PDFTQLDLE 241 Query: 293 MAFNYHYHEVMEEIADTMVQIFKGLQE-RFQTEIQTVNKQFPCEPFKFLEPTLR--LEYC 349 M+F +V+E M +F+ ++ + E + +P LR LE Sbjct: 242 MSFVE-VEDVLELNERLMAHVFREALGVELPLPFPRLSYEEAMERYGSDKPDLRFGLELK 300 Query: 350 EALAMLREAGVEMGDEDD 367 E + R++G + E + Sbjct: 301 EVGPLFRQSGFRVFQEAE 318 Score = 122 bits (305), Expect = 4e-28, Method: Composition-based stats. Identities = 38/139 (27%), Positives = 60/139 (43%), Gaps = 17/139 (12%) Query: 367 DLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEIL 426 D + H + D +L+K P VR YD+ + G E+ Sbjct: 432 DEEEEAWTYMHHPFTSPHPEDLPLLEKDPGRVRALA-------------YDLVLNGVEVG 478 Query: 427 SGAQRIHDPQLLTERALHHGIDLE----KIKAYIDSFRFGAPPHAGGGIGLERVTMLFLG 482 G+ RIHDP+L GI E K ++++ +GAPPH G GL+R+ L G Sbjct: 479 GGSIRIHDPRLQARVFRLLGIGEEEQREKFGFFLEALEYGAPPHGGIAWGLDRLLALMTG 538 Query: 483 LHNVRQTSMFPRDPKRLTP 501 ++R+ FP++ + P Sbjct: 539 SPSIREVIAFPKNKEGKDP 557 >4AH6-A nrPDB Length = 617 Score = 216 bits (549), Expect = 2e-56, Method: Composition-based stats. Identities = 71/304 (23%), Positives = 121/304 (39%), Gaps = 23/304 (7%) Query: 50 DLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANIN 109 +L + V + + R + FLVLR VQ ++ D ++ + K Sbjct: 17 ELRSSHLGQEVTLCGWIQYRR---QNTFLVLRDFDGLVQVII-PQDESAASVKKILCEAP 72 Query: 110 KESIVDVEGVV--RKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGE 167 ES+V V G V R Q+ ++E+ V+ +++ + +LP ++ + V+ Sbjct: 73 VESVVQVSGTVISRPAGQENPKMPTGEIEIKVKTAELLNACK-KLPFEIKNFVKK----- 126 Query: 168 EEGRATVNQDTRLDNRVIDLRTSTSQAVFRLQSGICHLFRETLIN-KGFVEIQTPKIISA 226 + RL R +DLR+ Q RL+S + RE L N GFV+I+TP + Sbjct: 127 -------TEALRLQYRYLDLRSFQMQYNLRLRSQMVMKMREYLCNLHGFVDIETPTLFKR 179 Query: 227 ASEGGANVFTVSYFKNNAY-LAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTE 285 G S Y L QSPQ +KQ+ + ++ F + +R E S R E Sbjct: 180 TPGGAKEFLVPSREPGKFYSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PE 238 Query: 286 FVGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLR 345 F +DIEM+F + I + + ++ T+ + +P R Sbjct: 239 FTQIDIEMSF-VDQTGIQSLIEGLLQYSWPNDKDPVVVPFPTMTFAEVLATYGTDKPDTR 297 Query: 346 LEYC 349 Sbjct: 298 FGMK 301 Score = 112 bits (281), Expect = 3e-25, Method: Composition-based stats. Identities = 44/233 (18%), Positives = 88/233 (37%), Gaps = 21/233 (9%) Query: 267 SIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQ 326 I PVF + N + + F+ + +ME + +V + G + + + Sbjct: 359 EILPVFLNANRNWNSPVANFIMESQRLELI----RLMETQEEDVVLLTAGEHNKACSLLG 414 Query: 327 TVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDT 386 + + + + LR + + + + + E++ +E Sbjct: 415 KLRLEC-ADLLETRGVVLRDPTLFSFLWVVDFPLFLPKEENP------------RELESA 461 Query: 387 DFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERAL-HH 445 +P + YT P S YD+ + G EI G+ RIH+ +L Sbjct: 462 HHPFTAPHPSDIHLLYTEPKKAR---SQHYDLVLNGNEIGGGSIRIHNAELQRYILATLL 518 Query: 446 GIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPRDPKR 498 D++ + + + +GAPPH G +GL+R+ L G ++R FP+ + Sbjct: 519 KEDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSFRG 571 >3A5Z-A nrPDB Length = 328 Score = 213 bits (543), Expect = 1e-55, Method: Composition-based stats. Identities = 59/320 (18%), Positives = 121/320 (37%), Gaps = 26/320 (8%) Query: 195 VFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANVFTVSYF--------KNNAYL 246 ++ I R ++G +E++TP +S A+ ++ N +L Sbjct: 18 NLLKRAAIMAEIRRFFADRGVLEVETP-CMSQATVTDIHLVPFETRFVGPGHSQGMNLWL 76 Query: 247 AQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEI 306 SP+ + + + A VF + FR E+ H EF L+ +Y + +M E+ Sbjct: 77 MTSPEYHMKRLLVAGCGPVFQLCRSFRNEEMG-RYHNPEFTMLEWYRP-HYDMYRLMNEV 134 Query: 307 ADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREAGVEMGDED 366 D + Q+ + Q + +P + LR E A L + V E+ Sbjct: 135 DDLLQQVLDCPAAESLSYQQAFLRYLEIDPLSADKTQLR----EVAAKLDLSNV-ADTEE 189 Query: 367 DLSTPNEKLLGHLVK-EKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEI 425 D T + L V+ + +P + + + + + ++++ +G E+ Sbjct: 190 DRDTLLQLLFTFGVEPNIGKEKPTFVYHFPAS-QASLAQISTEDHRVAERFEVYYKGIEL 248 Query: 426 LSGAQRIHDPQLLTERA-------LHHGIDLEK-IKAYIDSFRFGAPPHAGGGIGLERVT 477 +G + D + +R G+ + I++ + G P +G +G++R+ Sbjct: 249 ANGFHELTDAREQQQRFEQDNRKRAARGLPQHPIDQNLIEALKVGMPDCSGVALGVDRLV 308 Query: 478 MLFLGLHNVRQTSMFPRDPK 497 ML LG + + F D Sbjct: 309 MLALGAETLAEVIAFSVDRA 328 >1NNH-A nrPDB Length = 294 Score = 201 bits (511), Expect = 5e-52, Method: Composition-based stats. Identities = 70/326 (21%), Positives = 127/326 (38%), Gaps = 53/326 (16%) Query: 185 IDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEG--------GANVFT 236 +++ + +Q+ I + + +GF + P IIS ++ G Sbjct: 4 VEIISREISPTLDIQTKILEYMTDFFVKEGFKWL-LPVIISPITDPLWPDPAGEGMEPAE 62 Query: 237 VSYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAE--DSNTHRHLTEFVGLDIEMA 294 V + L S L+KQ+ I +K+F + P R E + RH EF LD E+ Sbjct: 63 VEIYGVKMRLTHSMILHKQLAIAMGLKKIFVLSPNIRLESRQKDDGRHAYEFTQLDFEVE 122 Query: 295 FNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAM 354 ++M I + +F+ +E ++FP T R E E + Sbjct: 123 -RAKMEDIMRLIERLVYGLFRKAEE-------WTGREFPK--------TKRFEVFEYSEV 166 Query: 355 LREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSN 414 L E G + ++ P F+I++ R FY D Sbjct: 167 LEEFGSDEKASQEMEEP----------------FWIIN----IPREFY---DREVDGFWR 203 Query: 415 SYDMFMRGE--EILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFG-APPHAGGGI 471 +YD+ + E+ SG +R + + + + G++ + + Y++ + G P AG GI Sbjct: 204 NYDLILPYGYGEVASGGEREWEYEKIVAKIRKAGLNEDSFRPYLEIAKAGKLKPSAGAGI 263 Query: 472 GLERVTMLFLGLHNVRQTSMFPRDPK 497 G+ER+ +G ++ + FPR P Sbjct: 264 GVERLVRFIVGAKHIAEVQPFPRIPG 289 >3P8T-A nrPDB Length = 294 Score = 196 bits (499), Expect = 2e-50, Method: Composition-based stats. Identities = 69/326 (21%), Positives = 123/326 (37%), Gaps = 53/326 (16%) Query: 185 IDLRTSTSQAVFRLQSGICHLFRETLINKGFVEIQTPKIISA-------ASEGGANVFTV 237 +++ + +Q+ I + ++GF + + + G V Sbjct: 4 VEIISRDIYKAIDIQTKILDYMTKFFTDRGFKWLLPIMLSPITDPLWPDPAGEGIRPAEV 63 Query: 238 SYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAED--SNTHRHLTEFVGLDIEMAF 295 + L S L+KQ+ I EK+F + P R E + RH EF LD E+ Sbjct: 64 DVYGVRMRLTHSMILHKQLAIAMGLEKIFVLSPNIRLESRRKDDGRHSYEFTQLDFEIE- 122 Query: 296 NYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFP-CEPFKFLEPTLRLEYCEALAM 354 +VM I + + +F+ +E ++FP FK + LE Sbjct: 123 GAKMKDVMRLIEELIYGLFRKAEE-------WTGREFPRARHFKVYDYKDILE------- 168 Query: 355 LREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSN 414 E G ++ S E+ F+I++ R FY D Sbjct: 169 ------EFGSDEKASMEMEE------------PFWIVN----IPREFY---DREENGVWK 203 Query: 415 SYDMFMRGE--EILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFG-APPHAGGGI 471 +YD+ + E+ SG +R + + + + G+ + + Y++ R G P AG GI Sbjct: 204 NYDLILPYGYGEVSSGGEREWEYEKIVAKIRAAGLKEDSFRPYLEIARAGKLKPSAGAGI 263 Query: 472 GLERVTMLFLGLHNVRQTSMFPRDPK 497 G+ER+ +G ++ + FPR P Sbjct: 264 GVERLVRFIVGAKHIAEVQPFPRVPG 289 >5GRO-A nrPDB Length = 115 Score = 69.1 bits (167), Expect = 4e-12, Method: Composition-based stats. Identities = 20/101 (19%), Positives = 45/101 (44%), Gaps = 6/101 (5%) Query: 50 DLTIQKADEVVWVRARVHTSRAKGKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANIN 109 +++ + ++V V +T R G F+ LR + VQ + D +SK K A + Sbjct: 19 EISEKDVGKIVKVAGWCNTYRDHGGVVFIDLRDKSGLVQLVC---DPSSKAYEK-ALEVR 74 Query: 110 KESIVDVEGVVRKVNQ--KIGSCTQQDVELHVQKIYVISLA 148 E ++ +G VR + +E+ ++++ + + + Sbjct: 75 SEFVLVAKGKVRLRGAGLENPKLKTGKIEIVLEELIIENKS 115 >3VQX-A nrPDB Length = 291 Score = 58.3 bits (139), Expect = 7e-09, Method: Composition-based stats. Identities = 30/131 (22%), Positives = 50/131 (38%), Gaps = 23/131 (17%) Query: 201 GICHLFRETLINKGFVEIQTPKIISAA----------SEGGANVFTVSYFKNNAYLA--Q 248 + +++GF+EI++P +I +E +F V N L Sbjct: 82 KLEREITRFFVDRGFLEIKSPILIPLEYIERMGIDNDTELSKQIFRV---DKNFCLRPML 138 Query: 249 SPQLY-----KQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDI-EMAFNYHYHEV 302 +P LY + K+F IGP +R E S+ HL EF L+ +M + Sbjct: 139 APNLYNYLRKLDRALPDPI-KIFEIGPCYRKE-SDGKEHLEEFTMLNFCQMGSGCTRENL 196 Query: 303 MEEIADTMVQI 313 I D + + Sbjct: 197 ESIITDFLNHL 207 >2ZNJ-A nrPDB Length = 308 Score = 54.0 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 37/215 (17%), Positives = 80/215 (37%), Gaps = 27/215 (12%) Query: 117 EGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQ 176 G + ++ + ++ Q++ ++ + +L + DA+ + + ++Q Sbjct: 17 RGSHMFLTRRDPPLSSFWTKVQYQRLKELNASGEQLEMGFSDALSRDRAFQGIEHQLMSQ 76 Query: 177 DTRLDNRVID-LRTSTSQ-AVFRLQSGICHLFRETLINKGFVEIQTPKIISAASEGGANV 234 R ++ LRT + A+ L+ + L +GFV++ TP II+ ++ + Sbjct: 77 G----KRHLEQLRTVKHRPALLELEEKLAKA----LHQQGFVQVVTPTIITKSALAKMTI 128 Query: 235 FT-------VSYFKNNAYLA--QSPQLY-----KQMCICADFEKVFSIGPVFRAEDSNTH 280 V + L +P LY + ++F IG +R E Sbjct: 129 GEDHPLFSQVFWLDGKKCLRPMLAPNLYTLWRELERLWDKPI-RIFEIGTCYRKESQGAQ 187 Query: 281 RHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIFK 315 HL EF L++ E + + D + + Sbjct: 188 -HLNEFTMLNL-TELGTPLEERHQRLEDMARWVLE 220 Score = 29.8 bits (65), Expect = 3.2, Method: Composition-based stats. Identities = 40/233 (17%), Positives = 78/233 (33%), Gaps = 45/233 (19%) Query: 275 EDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPC 334 E T +H + L+ ++A H ++ + T++ + + ++ F Sbjct: 82 EQLRTVKHRPALLELEEKLAKALHQQGFVQVVTPTIITKSALAKMTIGEDHPLFSQVFWL 141 Query: 335 EPFKFLEPTLR-----------------LEYCEALAMLREAGVEMGDEDDLSTPNEKLLG 377 + K L P L + E R+ ++ + N LG Sbjct: 142 DGKKCLRPMLAPNLYTLWRELERLWDKPIRIFEIGTCYRKESQGAQHLNEFTMLNLTELG 201 Query: 378 HLVKEKY----DTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIH 433 ++E++ D ++L+ +R F + + ++ D+ E+ SGA Sbjct: 202 TPLEERHQRLEDMARWVLEA--AGIREFELVTESSVV-YGDTVDVMKGDLELASGAM--- 255 Query: 434 DPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNV 486 P L E+ P G G GLER+ M+ G +V Sbjct: 256 GPHFLDEKWEIFD------------------PWVGLGFGLERLLMIREGTQHV 290 >6JP2-A nrPDB Length = 278 Score = 46.0 bits (107), Expect = 3e-05, Method: Composition-based stats. Identities = 30/127 (23%), Positives = 54/127 (42%), Gaps = 15/127 (11%) Query: 200 SGICHLFRETLINKGFVEIQTPKIIS-------AASEGGANVFTVSYFKNNAYLA--QSP 250 + + + + L+ +GF+E++TP IS +E V + L +P Sbjct: 67 TQLMNDIADALVAEGFIEVRTPIFISKDALARMTITEDKPLFKQVFWIDEKRALRPMLAP 126 Query: 251 QLYKQMCIC----ADFEKVFSIGPVFRAEDSNTHRHLTEFVGLD-IEMAFNYHYHEVMEE 305 LY M K+F +G FR E S++ HL EF L+ ++M EV++ Sbjct: 127 NLYSVMRDLRDHTDGPVKIFEMGSCFRKE-SHSGMHLEEFTMLNLVDMGPRGDATEVLKN 185 Query: 306 IADTMVQ 312 +++ Sbjct: 186 YISVVMK 192 >11AS-A nrPDB Length = 330 Score = 44.8 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 52/334 (15%), Positives = 100/334 (29%), Gaps = 53/334 (15%) Query: 192 SQAVFRLQSGICHLFRETLINK-----GFVEIQTPKIISAASEGGANVFTVSYFKNNAYL 246 + + + + + G +E+Q P + N+ Sbjct: 1 MKTAYIAKQRQISFVKSHFSRQLEERLGLIEVQAPILSRVGDGTQDNLSGAE-------- 52 Query: 247 AQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTE--FVGLDIEMAFN-------- 296 ++ Q+ + A FE V S+ R E + + Sbjct: 53 -KAVQVKVKALPDAQFEVVHSLAKWKRQTLGQHDFSAGEGLYTHMKALRPDEDRLSPLHS 111 Query: 297 -----YHYHEVMEEIADTMVQI---FKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEY 348 + + VM + + + + + V+++F PF L + + Sbjct: 112 VYVDQWDWERVMGDGERQFSTLKSTVEAIWAGIKATEAAVSEEFGLAPF--LPDQIHFVH 169 Query: 349 CEAL----AMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKY----PLAVRP 400 + L L G E DL +G + + + D D P + Sbjct: 170 SQELLSRYPDLDAKGRERAIAKDLGAVFLVGIGGKLSDGHRHDVRAPDYDDWSTPSELGH 229 Query: 401 FYTMPD--PRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHG-IDLEKIKAYID 457 D NP +++++ G + D L + G D +++ + Sbjct: 230 AGLNGDILVWNPVLEDAFELSSMGIRV--------DADTLKHQLALTGDEDRLELEWHQA 281 Query: 458 SFRFGAPPHAGGGIGLERVTMLFLGLHNVRQTSM 491 R P GGGIG R+TML L L ++ Q Sbjct: 282 LLRGEMPQTIGGGIGQSRLTMLLLQLPHIGQVQA 315 >4LNS-A nrPDB Length = 351 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 44/242 (18%), Positives = 72/242 (29%), Gaps = 33/242 (13%) Query: 273 RAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIFKGLQ--ERFQTEIQTVNK 330 R +D + H D EM + + + + +++ ++ E E Sbjct: 104 RVDDVLDNIHSVVVDQWDWEMVMKDDQRNL-AFLKEVVCKVYAAIRKTELAVCEKYKQKP 162 Query: 331 QFPCEPFKFLEPTLRLEYCE--ALAMLREAGVEMG--------------DEDDLSTPNEK 374 P L L Y A RE E G D D P+ Sbjct: 163 ILPETIQFVHAEHLLLAYPNLTAKEREREIAREYGAVFLIGIGAVLSSGDRHDARAPDYD 222 Query: 375 LLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDMFMR-----GEEILSGA 429 V+ +P +P TM + K N + E+ S Sbjct: 223 DWTSPVEAS-------QVVFPRTSKPIPTMNSLSSLKGLNGDILLYNPTLDDSLEVSSMG 275 Query: 430 QRIHDPQLLTERALHHGID-LEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVRQ 488 R++ + L + G D L K + + P GGGIG R+ M L ++ + Sbjct: 276 IRVN-AEALRHQISLTGDDSLLKSEWHQQLLNGEFPQTVGGGIGQSRMVMFMLRKKHIGE 334 Query: 489 TS 490 Sbjct: 335 VQ 336 >3TUP-A nrPDB Length = 415 Score = 38.6 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 39/253 (15%), Positives = 83/253 (32%), Gaps = 71/253 (28%) Query: 239 YFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYH 298 Y L ++ + A + +G V+R + ++ H F L+ F+ H Sbjct: 109 YLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRRDQIDSQ-HYPIFHQLEAVRLFSKH 167 Query: 299 YHEVMEEIADTMVQIFKGLQERFQTEIQTVNKQFPCEPFKFLEPTLRLEYCEALAMLREA 358 E+ I D R + +T EA+ ++ Sbjct: 168 --ELFAGIKDGESLQLFEQSSRSAHKQET-------------------HTMEAVKLV--- 203 Query: 359 GVEMGDEDDLSTPNEKLLGHLVKEKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYDM 418 E DL +L+ HL ++ + ++ +P +T P S++M Sbjct: 204 ------EFDLKQTLTRLMAHLFGDELE-IRWVDCYFP------FTHP---------SFEM 241 Query: 419 FMRGE----EILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLE 474 + E+L ++ ++ ++ ++I G+GLE Sbjct: 242 EINFHGEWLEVLGCG-------VMEQQLVNSAGAQDRIGW-------------AFGLGLE 281 Query: 475 RVTMLFLGLHNVR 487 R+ M+ + ++R Sbjct: 282 RLAMILYDIPDIR 294 >5LR8-A nrPDB Length = 938 Score = 36.3 bits (82), Expect = 0.032, Method: Composition-based stats. Identities = 36/174 (20%), Positives = 64/174 (36%), Gaps = 21/174 (12%) Query: 285 EFVGLDIEMAFNYHYHEVMEEI-ADTMVQIFKG--------LQERFQTEIQTVNKQFPCE 335 E LDI + E++E I + M I L+++ + N P Sbjct: 387 EKWSLDIMQKLLPRHVEIIETIDEELMNNIVSKYGTADISLLKQKLKDMRILDNVDLPAS 446 Query: 336 PFK-FLEPTLR-----LEYCEALAMLREAGVEMGDEDDLSTPNEKLLGHLVKEKYDTDFY 389 K F++P + +E E++A E E+ LS EK +E D + Sbjct: 447 VAKLFIKPKEKRGKLLVESLESIAEADEKTESQEVENILSETTEKKAESDSEEAPDAE-- 504 Query: 390 ILDKYPL-AVRPFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERA 442 + P + PF DP+ P+ ++ + G ++G IH + + Sbjct: 505 --KEDPEYELDPFAKY-DPQFPRVVRMANLCVVGGHSVNGVAEIHSEIVKQDVF 555 >3L4G-A nrPDB Length = 508 Score = 33.6 bits (75), Expect = 0.20, Method: Composition-based stats. Identities = 14/51 (27%), Positives = 23/51 (45%), Gaps = 2/51 (3%) Query: 264 KVFSIGPVFRAEDSNTHRHLTEFVGLDIEMA-FNYHYHEVMEEIADTMVQI 313 K FSI VFR E + HL EF ++ +A +M + + ++ Sbjct: 349 KYFSIDRVFRNETLDA-THLAEFHQIEGVVADHGLTLGHLMGVLREFFTKL 398 >2NSM-A nrPDB Length = 439 Score = 31.3 bits (69), Expect = 0.98, Method: Composition-based stats. Identities = 23/96 (23%), Positives = 38/96 (39%), Gaps = 22/96 (22%) Query: 252 LYKQMCICADFEKVFSIGPVFRAEDSNTHRHLT--EFVG-------LDIEMAFNYHYH-- 300 LYK C +V+SIG S RHL EF L+ E+ + + H Sbjct: 16 LYKVQNECPGITRVYSIGR------SVEGRHLYVLEFSDHPGIHEPLEPEVKYVGNMHGN 69 Query: 301 -----EVMEEIADTMVQIFKGLQERFQTEIQTVNKQ 331 E+M ++++ + + F+ +R IQ Sbjct: 70 EALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIH 105 >2ODR-C nrPDB Length = 701 Score = 31.3 bits (69), Expect = 0.99, Method: Composition-based stats. Identities = 15/71 (21%), Positives = 32/71 (45%), Gaps = 9/71 (12%) Query: 435 PQLLTERALHHG-----IDLEKIKAY--IDSFRFGA-PPHAGGGIGLERVTMLFLGLHNV 486 P+ TE +H +++ Y + ++G P G+G+ER+ M+ +V Sbjct: 295 PETQTEVYAYHPKLKEWLEVATFGVYSPVALSKYGIDVPVMNLGLGVERLAMISGNFADV 354 Query: 487 RQTSMFPRDPK 497 R+ +P+ + Sbjct: 355 REMV-YPQFYE 364 >1ADJ-A nrPDB Length = 421 Score = 31.3 bits (69), Expect = 1.0, Method: Composition-based stats. Identities = 52/321 (16%), Positives = 95/321 (29%), Gaps = 53/321 (16%) Query: 194 AVFRLQSGICHLFRETLINKGFVEIQTPKIISAA----SEGGA------NVFTVSYFKNN 243 R+ I R+ L G +E+ TP G A +FT Sbjct: 15 KELRMHQRIVATARKVLEAAGALELVTPIFEETQVFEKGVGAATDIVRKEMFTFQDRGGR 74 Query: 244 --------------AYLAQSPQLYKQMCICADFEKVFSIGPVFRAEDSNTHR----HLTE 285 AYL +++ Q +++ GP+FRAE R H Sbjct: 75 SLTLRPEGTAAMVRAYLEHGMKVWPQPV------RLWMAGPMFRAERPQKGRYRQFHQVN 128 Query: 286 FVGLDIEMAFNYHYHEVM--EEIADTMVQIFKGLQERFQTEIQTVNKQFPCEP-FKFLEP 342 + L E V+ E + + ++ K Sbjct: 129 YEALGSENPILDAEAVVLLYECLKELGLRRLKVKLSSVGDPEDRARYNAYLREVLSPHRE 188 Query: 343 TLRLEYCEALAMLREAGVEMGDEDDLSTPNE---KLLGHLVKEKYDTDFYILDKYPLAVR 399 L + E L ++ E D + E + + + E+ ++++ + Sbjct: 189 ALSEDSKERLEENPMRILDSKSERDQALLKELGVRPMLDFLGEEARAHLKEVERHLERLS 248 Query: 400 PFYTMPDPRNPKQSNSYDMFMRGEEILSGAQRIHDPQLLTERALHHGIDLEKIKAYIDSF 459 +P P D ++R A +H ++ + AL G + + + Sbjct: 249 ----VPYELEPALVRGLDYYVRT------AFEVHHEEIGAQSALGGGGRYDGLSELLGGP 298 Query: 460 RFGAPPHAGGGIGLERVTMLF 480 R P G G+ERV + Sbjct: 299 R---VPGVGFAFGVERVALAL 316 >2ALY-A nrPDB Length = 266 Score = 30.9 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 13/34 (38%), Positives = 19/34 (55%), Gaps = 6/34 (17%) Query: 460 RFGAPPH----AGG--GIGLERVTMLFLGLHNVR 487 R G PP G G+G+ER+ ML G+ ++R Sbjct: 216 RLGLPPAYRGVTGFAFGLGVERLAMLRYGIPDIR 249 >4P71-C nrPDB Length = 338 Score = 30.5 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 12/48 (25%), Positives = 20/48 (41%), Gaps = 12/48 (25%) Query: 440 ERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVR 487 ID EK + + G+G ER+ ML G++++R Sbjct: 289 NVLRMSNIDPEKFQGF------------AFGMGAERLAMLRYGVNDLR 324 >1UMG-A nrPDB Length = 362 Score = 30.5 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 13/58 (22%), Positives = 23/58 (39%), Gaps = 1/58 (1%) Query: 220 TPKIISAASEGGANVFTV-SYFKNNAYLAQSPQLYKQMCICADFEKVFSIGPVFRAED 276 TP ++ + G F V ++ A + +PQ + + I V+R ED Sbjct: 151 TPGLVIDPTMHGGFKFEVLDVYQGEAVMLSAPQEIYDLLALIGTPARYVIRRVYRNED 208 >3AMU-A nrPDB Length = 440 Score = 30.2 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 23/168 (13%), Positives = 59/168 (35%), Gaps = 21/168 (12%) Query: 26 KERYGISSMIQSQEKPDRVLVRVRDLTIQK--ADEVV--WVRARVHTSRAK--------- 72 + Y ++++ R++ T +E V R + R + Sbjct: 242 EALYKAMESVKTEPVDRRMIFVTNHATDMHLIGEEEVHRLENYRSYRLRGRVTLEPYDIE 301 Query: 73 GKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQ 132 G F + + +V+ + +++ + K +V+V G ++K + Sbjct: 302 GGHVFFEIDTKFGSVKCAAFEPTKQFRNVIRL---LRKGDVVEVYGSMKKDTINLEKIQI 358 Query: 133 QDV-ELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRATVNQDTR 179 ++ E+ V+K + R+ + A R + ++ R ++ R Sbjct: 359 VELAEIWVEKNPICPSCGRRM----ESAGRGQGFRCKKCRTKADEKLR 402 >1PYS-A nrPDB Length = 350 Score = 30.2 bits (66), Expect = 2.1, Method: Composition-based stats. Identities = 13/34 (38%), Positives = 19/34 (55%), Gaps = 6/34 (17%) Query: 460 RFGAPPH----AGG--GIGLERVTMLFLGLHNVR 487 R G PP G G+G+ER+ ML G+ ++R Sbjct: 300 RLGLPPAYRGVTGFAFGLGVERLAMLRYGIPDIR 333 >2DU4-A nrPDB Length = 534 Score = 30.2 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 11/36 (30%), Positives = 20/36 (55%), Gaps = 2/36 (5%) Query: 460 RFGAP-PHAGGGIGLERVTMLFLGLHNVRQTSMFPR 494 + P P G+G+ER+ M+ G +VR+ +P+ Sbjct: 316 EYDIPYPVMNLGLGVERLAMILYGYDDVRKMV-YPQ 350 >3PCO-A nrPDB Length = 327 Score = 29.8 bits (65), Expect = 3.1, Method: Composition-based stats. Identities = 13/48 (27%), Positives = 21/48 (43%), Gaps = 12/48 (25%) Query: 440 ERALHHGIDLEKIKAYIDSFRFGAPPHAGGGIGLERVTMLFLGLHNVR 487 + GID E + G+G+ER+TML G+ ++R Sbjct: 278 NVLRNVGIDPEVYSGF------------AFGMGMERLTMLRYGVTDLR 313 >4WZY-A nrPDB Length = 454 Score = 29.4 bits (64), Expect = 3.4, Method: Composition-based stats. Identities = 22/142 (15%), Positives = 34/142 (23%), Gaps = 3/142 (2%) Query: 55 KADEVVWVRARVHTSRAKGKQCFLVLRQQQFNV-QALVAVGDHASKQMVKFAANINKESI 113 + + V+ H +R G +V S + A +E Sbjct: 163 ELNRVLAQAGNRHVARLLGSFETSWAGPGTDRCALGMVTAFAANSAEGWDMATASAREMF 222 Query: 114 VDVEGVVRKVNQKIGSCTQQDVELHVQKIYVISLAEPRLPLQLDDAVRPEAEGEEEGRAT 173 DV G +H + + P+ A A A Sbjct: 223 ADVVGSDFADESYRLGNAVA--SVHATLAEALGTSTEPFPVDTVLARLQSAARSAPELAG 280 Query: 174 VNQDTRLDNRVIDLRTSTSQAV 195 R +D R T Q V Sbjct: 281 RAAAVEERYRRLDGRAITVQRV 302 >3MKD-A nrPDB Length = 692 Score = 29.0 bits (63), Expect = 4.8, Method: Composition-based stats. Identities = 13/74 (17%), Positives = 28/74 (37%) Query: 7 SRKSQEKPREIMDAAEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADEVVWVRARV 66 + + E A + A +G++ + + + ++ RDL Q + +R Sbjct: 359 EKGAGEGAVLKDKTALNAASTVFGVNPSVLEKALMEPRILAGRDLVAQHLNVEKSSSSRD 418 Query: 67 HTSRAKGKQCFLVL 80 +A + FL L Sbjct: 419 ALVKALYGRLFLWL 432 >2JJ9-A nrPDB Length = 788 Score = 29.0 bits (63), Expect = 5.2, Method: Composition-based stats. Identities = 13/74 (17%), Positives = 28/74 (37%) Query: 7 SRKSQEKPREIMDAAEDYAKERYGISSMIQSQEKPDRVLVRVRDLTIQKADEVVWVRARV 66 + + E A + A +G++ + + + ++ RDL Q + +R Sbjct: 371 EKGAGEGAVLKDKTALNAASTVFGVNPSVLEKALMEPRILAGRDLVAQHLNVEKSSSSRD 430 Query: 67 HTSRAKGKQCFLVL 80 +A + FL L Sbjct: 431 ALVKALYGRLFLWL 444 >1KA4-A nrPDB Length = 499 Score = 28.6 bits (62), Expect = 5.8, Method: Composition-based stats. Identities = 26/175 (14%), Positives = 50/175 (28%), Gaps = 13/175 (7%) Query: 255 QMCICADFEKVFSIGPVFRAEDSNTHRHLTEFVGLDIEMAFNYHYHEVMEEIADTMVQIF 314 + I ++ I F E T E A E D ++ + Sbjct: 83 ERGIVRVLDRSIRIARAFPPEFIREVSETTSLATKAWEEAKAKDDFSKFEPWLDKIISLA 142 Query: 315 KGLQERFQTEIQTVN-----KQFPCEPFKFLEPTLRLEYCEALAMLREAGVE--MGDEDD 367 K E E + + + + LE + +L + E + E Sbjct: 143 KRAAEYLGYEEEPYDALLDLYEEGLRTRDVEKMFEVLE-KKLKPLLDKILEEGKVPREHP 201 Query: 368 LSTPN-EKLLGHLVK----EKYDTDFYILDKYPLAVRPFYTMPDPRNPKQSNSYD 417 L E+ V +K+ + ++ PF T R+ + + Y+ Sbjct: 202 LEKEKYEREWMERVNLWILQKFGFPLGTRARLDVSAHPFTTEFGIRDVRITTRYE 256 >3AU7-A nrPDB Length = 402 Score = 28.6 bits (62), Expect = 6.7, Method: Composition-based stats. Identities = 20/148 (13%), Positives = 46/148 (31%), Gaps = 24/148 (16%) Query: 26 KERYGISSMIQSQEKPDRVLVRVRDLTIQK--ADEVV--WVRARVHTSRAK--------- 72 + Y ++++ R++ T +E V R + R + Sbjct: 242 EALYKAMESVKTEPVDRRMIFVTNHATDMHLIGEEEVHRLENYRSYRLRGRVTLEPYDIE 301 Query: 73 GKQCFLVLRQQQFNVQALVAVGDHASKQMVKFAANINKESIVDVEGVVRKVNQKIGSCTQ 132 G F + + +V+ + +++ + K +V+V G ++K + Sbjct: 302 GGHVFFEIDTKFGSVKCAAFEPTKQFRNVIRL---LRKGDVVEVYGSMKKDTINLEKIQI 358 Query: 133 QDV--------ELHVQKIYVISLAEPRL 152 ++ EL V A L Sbjct: 359 VELAEGSGSERELQPGFYEVPPSARRHL 386 >5VM7-A nrPDB Length = 420 Score = 28.6 bits (62), Expect = 6.8, Method: Composition-based stats. Identities = 18/71 (25%), Positives = 25/71 (35%), Gaps = 3/71 (4%) Query: 214 GFVEIQTPKIIS--AASEGGANVFTVSYF-KNNAYLAQSPQLYKQMCICADFEKVFSIGP 270 + E+ T I A E F V +F LAQ QLY + I F++ Sbjct: 297 DWKELATAFINPHEVAWELTPYSFVVDWFLNVGDILAQQGQLYHNIDIVDGFDRRDIRLK 356 Query: 271 VFRAEDSNTHR 281 F + R Sbjct: 357 SFTIKGERNGR 367 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.307 0.122 0.304 Lambda K H 0.267 0.0376 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,570,040 Number of Sequences: 36641 Number of extensions: 622822 Number of successful extensions: 2114 Number of sequences better than 10.0: 63 Number of HSP's better than 10.0 without gapping: 82 Number of HSP's successfully gapped in prelim test: 25 Number of HSP's that attempted gapping in prelim test: 1695 Number of HSP's gapped (non-prelim): 146 length of query: 501 length of database: 10,336,785 effective HSP length: 101 effective length of query: 400 effective length of database: 6,636,044 effective search space: 2654417600 effective search space used: 2654417600 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 61 (28.2 bits)