BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P14550 (325 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2ALR-A nrPDB 672 0.0 1HQT-A nrPDB 636 0.0 4GAC-A nrPDB 634 0.0 1ZUA-X nrPDB 319 1e-87 1DLA-A nrPDB 311 2e-85 3RX4-A nrPDB 300 5e-82 4HBK-A nrPDB 297 5e-81 1FRB-A nrPDB 296 8e-81 1C9W-A nrPDB 290 6e-79 3O3R-A nrPDB 285 1e-77 4JQA-A nrPDB 276 8e-75 3G1R-A nrPDB 275 2e-74 2FVL-A nrPDB 274 3e-74 5JH1-A nrPDB 271 2e-73 1Q5M-A nrPDB 266 9e-72 5JM5-A nrPDB 263 8e-71 5UXF-A nrPDB 262 1e-70 3H7U-A nrPDB 254 3e-68 2HE8-A nrPDB 254 3e-68 5ZCM-A nrPDB 249 1e-66 1AFS-A nrPDB 248 3e-66 3H7R-A nrPDB 241 3e-64 3WCZ-A nrPDB 238 3e-63 1K8C-A nrPDB 231 3e-61 4F40-A nrPDB 228 3e-60 5Z6T-A nrPDB 226 1e-59 3KRB-A nrPDB 225 2e-59 4GIE-A nrPDB 218 3e-57 1VBJ-A nrPDB 214 4e-56 2BGQ-A nrPDB 213 8e-56 1QWK-A nrPDB 206 1e-53 3D3F-A nrPDB 204 5e-53 1MZR-A nrPDB 199 1e-51 1VP5-A nrPDB 186 9e-48 4MHB-A nrPDB 179 1e-45 1A80-A nrPDB 170 1e-42 4IJC-A nrPDB 168 2e-42 4OTK-A nrPDB 165 3e-41 3UP8-A nrPDB 157 8e-39 3WG6-A nrPDB 144 7e-35 4H8N-A nrPDB 126 1e-29 1PZ1-A nrPDB 60 1e-09 1LQA-A nrPDB 60 2e-09 1PYF-A nrPDB 58 5e-09 3N6Q-A nrPDB 50 1e-06 3EB3-A nrPDB 43 2e-04 1GVE-A nrPDB 40 0.001 1OG6-A nrPDB 38 0.006 4R9O-A nrPDB 38 0.006 2BP1-A nrPDB 35 0.032 2C91-A nrPDB 34 0.069 2CLP-A nrPDB 33 0.21 5XKX-A nrPDB 32 0.35 3EC2-A nrPDB 30 2.1 5M0X-A nrPDB 29 3.2 3PS9-A nrPDB 28 3.9 2Y4N-A nrPDB 28 6.5 4EXA-A nrPDB 28 7.4 4PAF-A nrPDB 27 9.7 >2ALR-A nrPDB Length = 324 Score = 672 bits (1733), Expect = 0.0, Method: Compositional matrix adjust. Identities = 324/324 (100%), Positives = 324/324 (100%) Query: 2 AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 61 AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK Sbjct: 1 AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 60 Query: 62 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG Sbjct: 61 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 120 Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPA 181 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPA Sbjct: 121 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPA 180 Query: 182 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKY 241 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKY Sbjct: 181 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKY 240 Query: 242 GRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVP 301 GRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVP Sbjct: 241 GRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVP 300 Query: 302 MLTVDGKRVPRDAGHPLYPFNDPY 325 MLTVDGKRVPRDAGHPLYPFNDPY Sbjct: 301 MLTVDGKRVPRDAGHPLYPFNDPY 324 >1HQT-A nrPDB Length = 326 Score = 636 bits (1640), Expect = 0.0, Method: Compositional matrix adjust. Identities = 304/325 (93%), Positives = 318/325 (97%) Query: 1 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL 60 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAA+KYAL+VGYRHIDCAAI+GNE EIGEAL Sbjct: 2 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAIKYALTVGYRHIDCAAIFGNELEIGEAL 61 Query: 61 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 120 +E VGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER Sbjct: 62 QETVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 121 Query: 121 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP 180 GDNPFPKNADGTI YD+THYK+TWKALEALVAKGLV+ALGLSNF+SRQIDD+LSVASVRP Sbjct: 122 GDNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDDVLSVASVRP 181 Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDP+EPVLLEEPVV ALAEK Sbjct: 182 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPNEPVLLEEPVVQALAEK 241 Query: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 300 Y RSPAQILLRWQVQRKVICIPKS+TPSRI QNI+VFDFTFSPEEMKQL+ALNKN R+IV Sbjct: 242 YNRSPAQILLRWQVQRKVICIPKSVTPSRIPQNIQVFDFTFSPEEMKQLDALNKNLRFIV 301 Query: 301 PMLTVDGKRVPRDAGHPLYPFNDPY 325 PMLTVDGKRVPRDAGHPLYPFNDPY Sbjct: 302 PMLTVDGKRVPRDAGHPLYPFNDPY 326 >4GAC-A nrPDB Length = 324 Score = 634 bits (1635), Expect = 0.0, Method: Compositional matrix adjust. Identities = 302/324 (93%), Positives = 313/324 (96%) Query: 2 AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 61 AS VLLHTGQKMPLIGLGTWKSEPGQVKAA+K+ALS GYRHIDCA++YGNE EIGEALK Sbjct: 1 TASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 60 Query: 62 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 E VG GKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG Sbjct: 61 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 120 Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPA 181 DNPFPKNADGT+ YDSTHYKETWKALE LVAKGLV+ALGLSNFNSRQIDD+LSVASVRPA Sbjct: 121 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPA 180 Query: 182 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKY 241 VLQVECHPYLAQNELIAHC ARGLEVTAYSPLGSSDRAWR PDEPVLLEEPVVLALAEK+ Sbjct: 181 VLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKH 240 Query: 242 GRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVP 301 GRSPAQILLRWQVQRKVICIPKSI PSRILQNI+VFDFTFSPEEMKQL+ALNKNWRYIVP Sbjct: 241 GRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVP 300 Query: 302 MLTVDGKRVPRDAGHPLYPFNDPY 325 M+TVDGKRVPRDAGHPLYPFNDPY Sbjct: 301 MITVDGKRVPRDAGHPLYPFNDPY 324 >1ZUA-X nrPDB Length = 317 Score = 319 bits (818), Expect = 1e-87, Method: Compositional matrix adjust. Identities = 159/325 (48%), Positives = 217/325 (66%), Gaps = 12/325 (3%) Query: 3 ASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62 A+ V L T KMP++GLGTWKS G+VK AVK A+ GYRHIDCA +Y NE E+GEA++E Sbjct: 3 ATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQE 62 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + KAV RE+LF+ SKLW T V A KTL DL+L YLD+YL+HWP F+ GD Sbjct: 63 KIQE-KAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGD 121 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR--P 180 + FPK+ G + + W+A+E LV +GLV+ALG+SNF+ QI+ +L+ ++ P Sbjct: 122 DLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKP 181 Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240 QVECHPYL Q +LI +C ++G+ VTAYSPLGS DR W P++P LLE+P + +A K Sbjct: 182 VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK 241 Query: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 300 + ++ AQ+L+R+ +QR VI IPKS+TP+RI++NI+VFDF S EEM + + N+NWR Sbjct: 242 HKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWR--- 298 Query: 301 PMLTVDGKRVPRDAGHPLYPFNDPY 325 V + + YPFN Y Sbjct: 299 ------ACNVLQSSHLEDYPFNAEY 317 >1DLA-A nrPDB Length = 314 Score = 311 bits (798), Expect = 2e-85, Method: Compositional matrix adjust. Identities = 163/324 (50%), Positives = 227/324 (70%), Gaps = 12/324 (3%) Query: 4 SCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKED 63 S ++L+TG KMP++GLGTWKS PG+V AVK A+ +GYRHIDCA +Y NE E+G L+E Sbjct: 1 SHLVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQEK 60 Query: 64 VGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDN 123 + G+ V RE+LF+ SKLW T H V+ A + TL DL+L+YLDLYL+HWP F+ G + Sbjct: 61 LQ-GQVVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGKD 119 Query: 124 PFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR--PA 181 PFP + DG + D + + ETW+A+E LV +GLV+A+G+SNFN Q++ IL+ ++ PA Sbjct: 120 PFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPA 179 Query: 182 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKY 241 V Q+E HPYL Q +LI +C+++G+ VTAYSPLGS DR W P++P LLE+P + A+A KY Sbjct: 180 VNQIEVHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKY 239 Query: 242 GRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVP 301 ++ AQ+L+R+ +QR +I IPKS+TP RI +N +VFDF SPE+M L + N+NWR Sbjct: 240 NKTTAQVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRVCAL 299 Query: 302 MLTVDGKRVPRDAGHPLYPFNDPY 325 M A H YPF++ Y Sbjct: 300 MSC---------ASHKDYPFHEEY 314 >3RX4-A nrPDB Length = 336 Score = 300 bits (769), Expect = 5e-82, Method: Compositional matrix adjust. Identities = 161/325 (49%), Positives = 226/325 (69%), Gaps = 12/325 (3%) Query: 3 ASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62 AS +LL+ G KMP++GLGTWKS PGQV AVK A+ VGYRHIDCA +Y NE E+G A++E Sbjct: 22 ASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQE 81 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + + V REELF+ SKLW T H V+ A +KTL+DL+L+YLDLYL+HWP F+ G Sbjct: 82 KLRE-QVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK 140 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR--P 180 FP + G + T+ +TW A+E LV +GLV+A+G+SNFN Q++ IL+ ++ P Sbjct: 141 EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP 200 Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240 AV Q+ECHPYL Q +LI +CQ++G+ VTAYSPLGS DR W P++P LLE+P + A+A K Sbjct: 201 AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK 260 Query: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 300 + ++ AQ+L+R+ +QR ++ IPKS+TP RI +N KVFDF S ++M L + N+NWR + Sbjct: 261 HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWR-VC 319 Query: 301 PMLTVDGKRVPRDAGHPLYPFNDPY 325 +L+ H YPF++ + Sbjct: 320 ALLSC--------TSHKDYPFHEEF 336 >4HBK-A nrPDB Length = 344 Score = 297 bits (760), Expect = 5e-81, Method: Compositional matrix adjust. Identities = 147/318 (46%), Positives = 213/318 (66%), Gaps = 13/318 (4%) Query: 8 LHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPG 67 ++ G+ +P+IGLGTW S PG+V AAVK AL +GYRH+DCA +Y NE EIGEAL+ + Sbjct: 40 MNNGRSIPVIGLGTWNSPPGEVGAAVKKALEIGYRHLDCAYVYRNEAEIGEALENALNSL 99 Query: 68 KAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPK 127 + + RE++F+TSKLWNT PE V A +TL +L+L YLDLYL+HWP + G + FP Sbjct: 100 R-LKREDIFITSKLWNTFFRPEHVRKACEETLKNLRLNYLDLYLIHWPVPLKHGGDLFPT 158 Query: 128 NADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVEC 187 +++G +C D+ +++TWK +E LV +GLV+++GLSNFN RQI +IL ++PA LQ+E Sbjct: 159 DSNGQLCLDNVPHEDTWKEMEKLVDEGLVKSIGLSNFNKRQIQNILEHCRIKPANLQIEI 218 Query: 188 HPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQ 247 H +L+ + Q+ GL VTAY+PLGS + P + LL +P VL +A ++ ++PAQ Sbjct: 219 HANFPNIKLVEYAQSVGLTVTAYAPLGSPAHS---PGKVNLLTKPCVLEIAHRHKKTPAQ 275 Query: 248 ILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDG 307 +LLR+ +QRK+I +PKS+T RI +N +VFDF S EEM +LN + N R + Sbjct: 276 VLLRYLLQRKLIVVPKSVTFKRIEENFQVFDFQLSNEEMHELNTESLNERQFTLL----- 330 Query: 308 KRVPRDAGHPLYPFNDPY 325 + +GH YPF + Y Sbjct: 331 ----QMSGHQEYPFKEEY 344 >1FRB-A nrPDB Length = 315 Score = 296 bits (758), Expect = 8e-81, Method: Compositional matrix adjust. Identities = 159/314 (50%), Positives = 216/314 (68%), Gaps = 3/314 (0%) Query: 3 ASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62 A+ V L T KMP++GLGTWKS P QVK AVK A+ GYRHIDCA Y NE E+GEA++E Sbjct: 1 ATFVELSTKAKMPIVGLGTWKSPPNQVKEAVKAAIDAGYRHIDCAYAYCNENEVGEAIQE 60 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + KAV RE+LF+ SKLW T + ++ A +KTL DL+L+YLDLYL+HWP + G Sbjct: 61 KIKE-KAVQREDLFIVSKLWPTCFEKKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGK 119 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR--P 180 FPK+ G I T + E W+ +E LV +GLV+ALG+SNFN QI+ +L+ ++ P Sbjct: 120 ELFPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKP 179 Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240 QVECHPYL Q +LI +C ++G+ VTAYSPLGS DR P++P LLE+P + +A K Sbjct: 180 VTNQVECHPYLTQEKLIQYCHSKGISVTAYSPLGSPDRPSAKPEDPSLLEDPKIKEIAAK 239 Query: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 300 + ++ AQ+L+R+ +QR V+ IPKS+TPSRI +NI+VFDF S EEM + + N+NWR + Sbjct: 240 HEKTSAQVLIRFHIQRNVVVIPKSVTPSRIQENIQVFDFQLSDEEMATILSFNRNWRACL 299 Query: 301 PMLTVDGKRVPRDA 314 TV+ + P DA Sbjct: 300 LPETVNMEEYPYDA 313 >1C9W-A nrPDB Length = 315 Score = 290 bits (742), Expect = 6e-79, Method: Compositional matrix adjust. Identities = 153/314 (48%), Positives = 215/314 (68%), Gaps = 3/314 (0%) Query: 3 ASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62 ++ V L T KMP++GLGTW+S PGQVK AVK A+ GYRHIDCA Y NE E+GEA++E Sbjct: 1 STFVELSTKAKMPIVGLGTWQSPPGQVKEAVKVAIDAGYRHIDCAYAYYNEHEVGEAIQE 60 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + KAV RE+LF+ SKLW T + ++ A +KTL DL+L+YLDLYL+HWP + G Sbjct: 61 KIKE-KAVRREDLFIVSKLWPTCFERKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGK 119 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR--P 180 FPK+ G + + + W+ +E LV +GLV+ALG+SNFN QI+ IL+ ++ P Sbjct: 120 ELFPKDDQGNVLTSKITFLDAWEVMEELVDEGLVKALGVSNFNHFQIERILNKPGLKHKP 179 Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240 QVECHPYL Q +LI +C ++G+ VTAYSPLGS +R W P++P LLE+P + +A K Sbjct: 180 VTNQVECHPYLTQEKLIEYCHSKGITVTAYSPLGSPNRPWAKPEDPSLLEDPKIKEIAAK 239 Query: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 300 + ++ AQ+L+R+ +QR V+ IPKS+TP+RI +N +VFDF S +EM + N+NWR + Sbjct: 240 HKKTSAQVLIRFHIQRNVVVIPKSVTPARIHENFQVFDFQLSDQEMATILGFNRNWRACL 299 Query: 301 PMLTVDGKRVPRDA 314 TV+ + P DA Sbjct: 300 LPETVNMEEYPYDA 313 >3O3R-A nrPDB Length = 316 Score = 285 bits (730), Expect = 1e-77, Method: Compositional matrix adjust. Identities = 151/311 (48%), Positives = 212/311 (68%), Gaps = 3/311 (0%) Query: 3 ASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62 + V L T KMPL+GLGTWKS PGQVK AVK A+ GYRH DCA +Y NE E+GEA++E Sbjct: 2 TTFVKLRTKAKMPLVGLGTWKSPPGQVKEAVKAAIDAGYRHFDCAYVYQNESEVGEAIQE 61 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + KAV RE+LF+ SKLW+T ++ A +KTL+DL+L+YLDLYL+HWP + G Sbjct: 62 KIKE-KAVRREDLFIVSKLWSTFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGLQAGK 120 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR--P 180 PK++ G + + + + W+ +E LV +GLV+ALG+SNFN QI+ +L+ ++ P Sbjct: 121 EFLPKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKP 180 Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240 QVECHPYL Q +LI +C ++G+ V AYSPLGS DR + P++PV+LE P + +A K Sbjct: 181 VTNQVECHPYLTQEKLIQYCHSKGIAVIAYSPLGSPDRPYAKPEDPVVLEIPKIKEIAAK 240 Query: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 300 + ++ AQ+L+R+ VQR V IPKS+T S I +NI+VFDF S E+M + +LN+NWR Sbjct: 241 HKKTIAQVLIRFHVQRNVAVIPKSVTLSHIKENIQVFDFQLSEEDMAAILSLNRNWRACG 300 Query: 301 PMLTVDGKRVP 311 +T D + P Sbjct: 301 LFVTSDEEDFP 311 >4JQA-A nrPDB Length = 331 Score = 276 bits (706), Expect = 8e-75, Method: Compositional matrix adjust. Identities = 144/327 (44%), Positives = 214/327 (65%), Gaps = 16/327 (4%) Query: 5 CVLLHTGQKMPLIGLGTWK-SEPGQVKA--AVKYALSVGYRHIDCAAIYGNEPEIGEALK 61 CV L+ G MP++G GT+ +E + KA AVK A+ G+ HID A +Y NE ++G A++ Sbjct: 7 CVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIR 66 Query: 62 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 + G +V RE++F TSKLW+ H PE V PAL ++L +LQL+Y+DLYL+H+P + + G Sbjct: 67 SKIADG-SVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPG 125 Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV--R 179 + PK+ +G I +D+ TW+A+E GL +++G+SNFN R ++ IL+ + + Sbjct: 126 EEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYK 185 Query: 180 PAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGS-SDRAWRDPDEPVLLEEPVVLALA 238 P QVECHPY Q +L+ C+++ + + AYS LGS + W DP+ PVLLE+PV+ ALA Sbjct: 186 PVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALA 245 Query: 239 EKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 298 +K+ R+PA I LR+Q+QR V+ + KS RI QN++VF+F + EEMK ++ LN+N RY Sbjct: 246 KKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRY 305 Query: 299 IVPMLTVDGKRVPRDAGHPLYPFNDPY 325 LT+D AG P YPF+D Y Sbjct: 306 ----LTLDIF-----AGPPNYPFSDEY 323 >3G1R-A nrPDB Length = 346 Score = 275 bits (702), Expect = 2e-74, Method: Compositional matrix adjust. Identities = 145/331 (43%), Positives = 211/331 (63%), Gaps = 17/331 (5%) Query: 2 AASCVLLHTGQKMPLIGLGTW---KSEP-GQVKAAVKYALSVGYRHIDCAAIYGNEPEIG 57 A+ + L G +P+IGLGT+ KS P G +VK A+ GYRHID A IY NE E+G Sbjct: 26 ASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVG 85 Query: 58 EALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYA 117 EA++E + GK V RE++F KLW T H PE V P L +TL LQL+Y+DLY++ P A Sbjct: 86 EAIREKIAEGK-VRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMA 144 Query: 118 FERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS 177 F+ GD +P++ +G Y ++ TW+A+EA GLV++LG+SNFN RQ++ IL+ Sbjct: 145 FKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPG 204 Query: 178 V--RPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSS-DRAWRDPDEPVLLEEPVV 234 + +P QVECHPY Q +L+ CQ + +TAYSPLG+S + W + P LL++ ++ Sbjct: 205 LKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALL 264 Query: 235 LALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNK 294 +L ++Y ++ AQI+LR+ +QR V+ IPKS RI +N ++FDF+ + EEMK + ALNK Sbjct: 265 NSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNK 324 Query: 295 NWRYIVPMLTVDGKRVPRDAGHPLYPFNDPY 325 N R++ ++ D HP YPF+D Y Sbjct: 325 NVRFVELLMWRD---------HPEYPFHDEY 346 >2FVL-A nrPDB Length = 324 Score = 274 bits (701), Expect = 3e-74, Method: Compositional matrix adjust. Identities = 138/326 (42%), Positives = 210/326 (64%), Gaps = 16/326 (4%) Query: 6 VLLHTGQKMPLIGLGTWKSEPGQVKAAV---KYALSVGYRHIDCAAIYGNEPEIGEALKE 62 V L+ G MP++G GT+ AV K A+ G+RHID A +Y NE ++G A++ Sbjct: 9 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 68 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + G +V RE++F TSKLW T P+ V+PAL +L LQL+Y+DLYL+H+P A + G+ Sbjct: 69 KIADG-SVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGE 127 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV--RP 180 P PK+ +G + +D+ TW+ +E GL +++G+SNFN RQ++ IL+ + +P Sbjct: 128 TPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKPGLKYKP 187 Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSS-DRAWRDPDEPVLLEEPVVLALAE 239 QVECHPYL Q++L+ C+++ + + A+S LG+ + W DP+ PVLLE+PV+ ALA+ Sbjct: 188 VCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAK 247 Query: 240 KYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYI 299 K+ R+PA I LR+Q+QR V+ + KS RI +NI+VF+F + E+MK L+ LN+N+RY+ Sbjct: 248 KHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYV 307 Query: 300 VPMLTVDGKRVPRDAGHPLYPFNDPY 325 V +D HP YPF+D Y Sbjct: 308 VMDFLMD---------HPDYPFSDEY 324 >5JH1-A nrPDB Length = 309 Score = 271 bits (694), Expect = 2e-73, Method: Compositional matrix adjust. Identities = 139/300 (46%), Positives = 197/300 (65%), Gaps = 16/300 (5%) Query: 3 ASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62 A +L+TG K+P +GLG+W+S+PG V AV A+ GYRHIDCA +YGNE EIG ALK+ Sbjct: 1 ARHFVLNTGAKIPSVGLGSWQSDPGVVGNAVYAAVKAGYRHIDCARVYGNEKEIGLALKK 60 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 G V RE++F+TSKLWN H PEDV AL +L DLQLEYLDLYL+HWP+ ++G Sbjct: 61 LFEEG-VVKREDMFITSKLWNDHHAPEDVPEALNDSLNDLQLEYLDLYLIHWPFRVKKGT 119 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAV 182 N P+N + + + TW A+E L G +A+G+SNF+S+++ D+L+VA V PAV Sbjct: 120 NTSPEN------FVTPDFPATWGAMEKLYDAGKARAIGVSNFSSKKLGDLLAVARVPPAV 173 Query: 183 LQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYG 242 QVECHP Q +L + CQ+ G+ +TAYSPLGS W + + +L+EP+++++AEK G Sbjct: 174 DQVECHPGWQQTKLHSFCQSTGVHLTAYSPLGSPGTTWMNGN---VLKEPIIISIAEKLG 230 Query: 243 RSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPE------EMKQLNALNKNW 296 ++ AQ+ LRW +Q +PKS RI QN+ V+D++ + E+KQ L N+ Sbjct: 231 KTSAQVALRWNIQMGHSVLPKSTNEERIKQNLDVYDWSIPDDLLAKFSEIKQARLLRGNF 290 >1Q5M-A nrPDB Length = 322 Score = 266 bits (680), Expect = 9e-72, Method: Compositional matrix adjust. Identities = 135/326 (41%), Positives = 203/326 (62%), Gaps = 16/326 (4%) Query: 6 VLLHTGQKMPLIGLGTWKSE---PGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62 V L G +P++G GT+ E + A K A+ G+RHID A Y NE E+G A++ Sbjct: 7 VALSDGHFIPVLGFGTYAPEEVPKSKAMEATKIAIDAGFRHIDSAYFYKNEKEVGLAIRS 66 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + G V RE++F TSKLW T H PE V P+L +L +LQL+Y+DLY++H+P A + G Sbjct: 67 KIADG-TVKREDIFYTSKLWCTFHRPELVRPSLEDSLKNLQLDYVDLYIIHFPTALKPGV 125 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV--RP 180 P + G +D+ TW+A+E GL +++G+SNFN RQ++ IL+ + +P Sbjct: 126 EIIPTDEHGKAIFDTVDICATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKP 185 Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGS-SDRAWRDPDEPVLLEEPVVLALAE 239 QVECHPYL Q +L+ C+++G+ + AYS LGS + W D PVLLE+P++ ALA+ Sbjct: 186 VCNQVECHPYLNQGKLLEFCKSKGIVLVAYSALGSHREPEWVDQSAPVLLEDPLIGALAK 245 Query: 240 KYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYI 299 K+ ++PA I LR+Q+QR ++ + KS T RI +NI+VF+F E+MK +++LN+N+RY+ Sbjct: 246 KHQQTPALIALRYQLQRGIVVLAKSFTEKRIKENIQVFEFQLPSEDMKVIDSLNRNFRYV 305 Query: 300 VPMLTVDGKRVPRDAGHPLYPFNDPY 325 + GHP YPF+D Y Sbjct: 306 TADFAI---------GHPNYPFSDEY 322 >5JM5-A nrPDB Length = 332 Score = 263 bits (672), Expect = 8e-71, Method: Compositional matrix adjust. Identities = 135/327 (41%), Positives = 205/327 (62%), Gaps = 16/327 (4%) Query: 5 CVLLHTGQKMPLIGLGTWKS-EPGQVKA--AVKYALSVGYRHIDCAAIYGNEPEIGEALK 61 CV L+ G MP++G GT+ E + KA K A+ G+RHID A +Y NE ++G A++ Sbjct: 7 CVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIR 66 Query: 62 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 + G +V RE++F TSKLW+T H PE V PAL +L QL+Y+DLYL+H P + + G Sbjct: 67 SKIADG-SVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPG 125 Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV--R 179 + P + +G + +D TW+A+E GL +++G+SNFN RQ++ IL+ + + Sbjct: 126 EELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYK 185 Query: 180 PAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSS-DRAWRDPDEPVLLEEPVVLALA 238 P QVECHPY +++L+ C+++ + + AYS LGS D+ W DP+ PVLLE+PV+ ALA Sbjct: 186 PVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALA 245 Query: 239 EKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 298 +K+ R+PA I LR+Q+QR V+ + KS RI QN++VF+F + E+MK ++ L++N Y Sbjct: 246 KKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHY 305 Query: 299 IVPMLTVDGKRVPRDAGHPLYPFNDPY 325 A HP YP++D Y Sbjct: 306 F---------NSDSFASHPNYPYSDEY 323 >5UXF-A nrPDB Length = 342 Score = 262 bits (670), Expect = 1e-70, Method: Compositional matrix adjust. Identities = 138/327 (42%), Positives = 202/327 (61%), Gaps = 16/327 (4%) Query: 5 CVLLHTGQKMPLIGLGTWKSE---PGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 61 CV L+ G +P +G GT+K + + A AL VGYRH+D A Y E EIG+A++ Sbjct: 26 CVKLNDGHLIPALGFGTYKPKEVPKSKSLEAACLALDVGYRHVDTAYAYQVEEEIGQAIQ 85 Query: 62 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 + G V RE+LFVT+KLW T PE V+PAL K+L LQL+Y+DLY+MH+P + G Sbjct: 86 SAIAAG-VVKREDLFVTTKLWCTCFRPELVKPALEKSLKKLQLDYVDLYIMHYPVPMKSG 144 Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV--R 179 DN FP N G D+ + +TW+ LE GLV+++G+SNFN RQ++ IL+ + + Sbjct: 145 DNDFPVNEQGKSLLDTVDFCDTWERLEECKDAGLVKSIGVSNFNHRQLERILNKPGLKYK 204 Query: 180 PAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSD-RAWRDPDEPVLLEEPVVLALA 238 P QVECH YL Q +L+ +C+++ + + AY LG+ + W D + PVLL +PV+ +A Sbjct: 205 PVCNQVECHLYLNQRKLLDYCESKDIVLVAYGALGTQRYKEWVDQNSPVLLNDPVLCDVA 264 Query: 239 EKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 298 +K RSPA I LR+ +QR ++ + +S + + +N++VF F SPE+MK L+ LNKN+RY Sbjct: 265 KKNKRSPALIALRYLIQRGIVPLAQSFKENEMRENLQVFGFQLSPEDMKTLDGLNKNFRY 324 Query: 299 IVPMLTVDGKRVPRDAGHPLYPFNDPY 325 + VD HP YPF + Y Sbjct: 325 LPAEFLVD---------HPEYPFVEEY 342 >3H7U-A nrPDB Length = 335 Score = 254 bits (650), Expect = 3e-68, Method: Compositional matrix adjust. Identities = 132/281 (46%), Positives = 181/281 (64%), Gaps = 11/281 (3%) Query: 2 AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 61 A + L+TG K P +GLGTW++ PG V AV A+ +GYRHIDCA IYGNE EIG LK Sbjct: 24 AITFFKLNTGAKFPSVGLGTWQASPGLVGDAVAAAVKIGYRHIDCAQIYGNEKEIGAVLK 83 Query: 62 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 + + + V RE+LF+TSKLW T H P+DV AL +TL DLQLEY+DLYL+HWP ++G Sbjct: 84 K-LFEDRVVKREDLFITSKLWCTDHDPQDVPEALNRTLKDLQLEYVDLYLIHWPARIKKG 142 Query: 122 DNPF-PKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP 180 P+N TWKA+EAL G +A+G+SNF+++++ D+L +A V P Sbjct: 143 SVGIKPEN------LLPVDIPSTWKAMEALYDSGKARAIGVSNFSTKKLADLLELARVPP 196 Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240 AV QVECHP Q +L C+++G+ ++AYSPLGS W D +L+ P++ +AEK Sbjct: 197 AVNQVECHPSWRQTKLQEFCKSKGVHLSAYSPLGSPGTTWLKSD---VLKNPILNMVAEK 253 Query: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTF 281 G+SPAQ+ LRW +Q +PKS RI +N VFD++ Sbjct: 254 LGKSPAQVALRWGLQMGHSVLPKSTNEGRIKENFNVFDWSI 294 >2HE8-A nrPDB Length = 323 Score = 254 bits (650), Expect = 3e-68, Method: Compositional matrix adjust. Identities = 128/327 (39%), Positives = 199/327 (60%), Gaps = 16/327 (4%) Query: 5 CVLLHTGQKMPLIGLGT---WKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 61 CV+L+ G +P++G GT + + K K A+ G+ H D A++Y E +GEA++ Sbjct: 7 CVILNDGNFIPVLGFGTALPLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAIR 66 Query: 62 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 + G V RE++F TSK+W T HPE V +L ++L LQ +Y+DLYL+H+P A + G Sbjct: 67 SKIADG-TVRREDIFYTSKVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKPG 125 Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV--R 179 + FP + G + +D TW+A+E GL +++G+SNFN RQ++ IL+ + + Sbjct: 126 EENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEMILNKPGLKYK 185 Query: 180 PAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDR-AWRDPDEPVLLEEPVVLALA 238 P QVECHPYL Q +L+ C+++ + + AY LG+ W D + PVLL+EPV+ ++A Sbjct: 186 PVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGGWVDQNSPVLLDEPVLGSMA 245 Query: 239 EKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 298 +KY R+PA I LR+Q+QR ++ + S+ RI +N++VF+F S E+MK L+ LN+N RY Sbjct: 246 KKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMRY 305 Query: 299 IVPMLTVDGKRVPRDAGHPLYPFNDPY 325 I + GHP +PF D Y Sbjct: 306 IPAAIF---------KGHPNWPFLDEY 323 >5ZCM-A nrPDB Length = 341 Score = 249 bits (635), Expect = 1e-66, Method: Compositional matrix adjust. Identities = 132/323 (40%), Positives = 197/323 (60%), Gaps = 23/323 (7%) Query: 5 CVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDV 64 + L++G +MPL+G G WK + V A+ VGYR D A YGN EIGE + + Sbjct: 23 SIKLNSGYEMPLVGFGCWKVDNATCADTVYNAIKVGYRLFDAAMDYGNCKEIGEGINRAL 82 Query: 65 GPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNP 124 G V R+ELF+TSKLWN+ H P++VE AL+K L+D++L+Y+DL+L+H+P AF+ P Sbjct: 83 DEG-LVARDELFITSKLWNSYHDPKNVELALKKVLSDMKLDYIDLFLIHFPIAFKFV--P 139 Query: 125 FPKN-------ADGTICYDSTHYK-----ETWKALEALVAKGLVQALGLSNFNSRQIDDI 172 F + DG D+ HY+ ETWKA+E L G +++G+SNF++ I D+ Sbjct: 140 FEEKYPPAFYCGDG----DNFHYEDVPLLETWKAMEKLTKGGKAKSIGISNFSAALIYDL 195 Query: 173 LSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSD----RAWRDPDEPVL 228 L A ++PAVLQ+E HPYL Q LI + Q++G+ +TAYS G + + D P L Sbjct: 196 LRGAEIKPAVLQIEHHPYLQQPRLIEYVQSQGIAITAYSSFGPQSFLELKHSKALDTPTL 255 Query: 229 LEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQ 288 E + ++A+KY ++PAQ+LLRW QR + IPKS P R+LQN++V DF S E+ + Sbjct: 256 FEHKTITSIADKYKKTPAQVLLRWASQRDIAIIPKSNNPDRLLQNLEVNDFNLSKEDFDE 315 Query: 289 LNALNKNWRYIVPMLTVDGKRVP 311 ++ L+++ R+ P R+P Sbjct: 316 ISKLDQDLRFNNPWDWDTKNRIP 338 >1AFS-A nrPDB Length = 323 Score = 248 bits (633), Expect = 3e-66, Method: Compositional matrix adjust. Identities = 127/324 (39%), Positives = 201/324 (62%), Gaps = 16/324 (4%) Query: 6 VLLHTGQKMPLIGLGTW---KSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62 V L+ G +P++G GT K +V A K A+ G+RH D A +Y E E+G+A++ Sbjct: 8 VALNDGNFIPVLGFGTTVPEKVAKDEVIKATKIAIDNGFRHFDSAYLYEVEEEVGQAIRS 67 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + G V RE++F TSKLW+T H PE V L KTL QL+Y+DLY++H+P A + GD Sbjct: 68 KIEDG-TVKREDIFYTSKLWSTFHRPELVRTCLEKTLKSTQLDYVDLYIIHFPMALQPGD 126 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV--RP 180 FP++ G + +++ +TW+A+E GL +++G+SNFN RQ++ IL+ + +P Sbjct: 127 IFFPRDEHGKLLFETVDICDTWEAMEKCKDAGLAKSIGVSNFNCRQLERILNKPGLKYKP 186 Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSS-DRAWRDPDEPVLLEEPVVLALAE 239 QVECH YL Q++++ +C+++ + + +Y LGSS D+ W D PVLL++PV+ A+A+ Sbjct: 187 VCNQVECHLYLNQSKMLDYCKSKDIILVSYCTLGSSRDKTWVDQKSPVLLDDPVLCAIAK 246 Query: 240 KYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYI 299 KY ++PA + LR+Q+QR V+ + +S RI + +VF+F + E+MK L+ LN+N+RY Sbjct: 247 KYKQTPALVALRYQLQRGVVPLIRSFNAKRIKELTQVFEFQLASEDMKALDGLNRNFRYN 306 Query: 300 VPMLTVDGKRVPRDAGHPLYPFND 323 D HP +PF D Sbjct: 307 NAKYFDD---------HPNHPFTD 321 >3H7R-A nrPDB Length = 331 Score = 241 bits (615), Expect = 3e-64, Method: Compositional matrix adjust. Identities = 127/280 (45%), Positives = 183/280 (65%), Gaps = 16/280 (5%) Query: 8 LHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPG 67 L+TG K+P +GLGT+ V A++ A+ +GYRHIDCA+IYGNE EIG LK+ +G G Sbjct: 30 LNTGAKLPCVGLGTY----AMVATAIEQAIKIGYRHIDCASIYGNEKEIGGVLKKLIGDG 85 Query: 68 KAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD-NPFP 126 V REELF+TSKLW+ H PEDV AL KTL DLQ++Y+DLYL+HWP + ++ P P Sbjct: 86 -FVKREELFITSKLWSNDHLPEDVPKALEKTLQDLQIDYVDLYLIHWPASLKKESLMPTP 144 Query: 127 KNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVE 186 + TWKA+EAL G +A+G+SNF+S+++ D+L+VA V PAV QVE Sbjct: 145 E------MLTKPDITSTWKAMEALYDSGKARAIGVSNFSSKKLTDLLNVARVTPAVNQVE 198 Query: 187 CHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPA 246 CHP Q L C+++G+ ++ YSPLGS + +L+ P+V +AEK G++ A Sbjct: 199 CHPVWQQQGLHELCKSKGVHLSGYSPLGSQSKG---EVRLKVLQNPIVTEVAEKLGKTTA 255 Query: 247 QILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEM 286 Q+ LRW +Q +PKS + +R+ +N+ VFD++ PE++ Sbjct: 256 QVALRWGLQTGHSVLPKSSSGARLKENLDVFDWSI-PEDL 294 >3WCZ-A nrPDB Length = 308 Score = 238 bits (607), Expect = 3e-63, Method: Compositional matrix adjust. Identities = 124/305 (40%), Positives = 184/305 (60%), Gaps = 18/305 (5%) Query: 1 MAASCVLLHTGQKMPLIGLGTWKSEP------GQVKAAVKYALSVGYRHIDCAAIYGNEP 54 + A C+ L+ G +P++ LGT + +V+ AV +A+ GYRHID AA+Y +E Sbjct: 3 VQAPCIQLNDGNTIPIVALGTGRGTAKESDSIDEVRQAVYWAIEAGYRHIDTAAVYQDEE 62 Query: 55 EIGEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHW 114 ++G+ + E + G V REELFVT+KLWN KH + V PAL+++L L L+Y+DLYL+H+ Sbjct: 63 QVGQGIAEAIANG-LVTREELFVTTKLWNDKHARDQVVPALQESLKKLGLDYIDLYLIHF 121 Query: 115 PYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILS 174 P A + D+P D+ Y ETW+ ++ GL +++G+SNFN+ QI ++S Sbjct: 122 PIATKPDDSP-----------DNIDYLETWQGMQDARQLGLARSIGVSNFNATQITRLVS 170 Query: 175 VASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVV 234 + +RP + Q+E +P Q L+AHCQ+ G+ V AYSP G + P ++P + Sbjct: 171 NSYIRPVINQIEVNPTNTQEPLVAHCQSLGIAVMAYSPFGFVVSRGQTGAPPPRSDDPTL 230 Query: 235 LALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNK 294 ALA KY +S QILLR+ + R +I IPKS RI QNI +FDF + EE+ +N NK Sbjct: 231 TALANKYRKSVGQILLRYLIDRGLIPIPKSTNKQRIAQNIDLFDFQLTFEEVAAINQFNK 290 Query: 295 NWRYI 299 N R I Sbjct: 291 NHRVI 295 >1K8C-A nrPDB Length = 322 Score = 231 bits (589), Expect = 3e-61, Method: Compositional matrix adjust. Identities = 130/313 (41%), Positives = 180/313 (57%), Gaps = 13/313 (4%) Query: 1 MAASC--VLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGE 58 M+AS + L +G MP IG G WK V A+ GYR D A YGNE E+G+ Sbjct: 1 MSASIPDIKLSSGHLMPSIGFGCWKLANATAGEQVYQAIKAGYRLFDGAEDYGNEKEVGD 60 Query: 59 ALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAF 118 +K + G V REE+F+TSKLWN H P++VE AL KTLADL+++Y+DL+L+H+P AF Sbjct: 61 GVKRAIDEG-LVKREEIFLTSKLWNNYHDPKNVETALNKTLADLKVDYVDLFLIHFPIAF 119 Query: 119 -----ERGDNPFPKNADGT-ICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDI 172 E P DG Y+ ETWKALE LVA G ++++G+SNF + D+ Sbjct: 120 KFVPIEEKYPPGFYCGDGNNFVYEDVPILETWKALEKLVAAGKIKSIGVSNFPGALLLDL 179 Query: 173 LSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSD----RAWRDPDEPVL 228 L A+++PAVLQVE HPYL Q +LI Q G+ +TAYS G R + P L Sbjct: 180 LRGATIKPAVLQVEHHPYLQQPKLIEFAQKAGVTITAYSSFGPQSFVEMNQGRALNTPTL 239 Query: 229 LEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQ 288 + A+A KY ++PA++LLRW QR + IPKS P R++QN F + E+ ++ Sbjct: 240 FAHDTIKAIAAKYNKTPAEVLLRWAAQRGIAVIPKSNLPERLVQNRSFNTFDLTKEDFEE 299 Query: 289 LNALNKNWRYIVP 301 + L+ R+ P Sbjct: 300 IAKLDIGLRFNDP 312 >4F40-A nrPDB Length = 288 Score = 228 bits (581), Expect = 3e-60, Method: Compositional matrix adjust. Identities = 119/296 (40%), Positives = 175/296 (59%), Gaps = 28/296 (9%) Query: 4 SCVLLHTGQKMPLIGLGTWKSEPGQV-KAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62 + V L G KMP GLG W+S G+V + AVK+AL GYRHID AAIY NE +G L+ Sbjct: 11 AMVTLSNGVKMPQFGLGVWQSPAGEVTENAVKWALCAGYRHIDTAAIYKNEESVGAGLR- 69 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 VPRE++F+T+KLWNT+ E A ++ L ++Y+DLYL+HWP RG Sbjct: 70 ----ASGVPREDVFITTKLWNTEQGYESTLAAFEESRQKLGVDYIDLYLIHWP----RGK 121 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAV 182 + K + Y ++W+A E L + V+A+G+SNF+ ++D+L++ +V P V Sbjct: 122 DILSK--------EGKKYLDSWRAFEQLYKEKKVRAIGVSNFHIHHLEDVLAMCTVTPMV 173 Query: 183 LQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYG 242 QVE HP Q +L A C A+ ++V A+SPLG LL P++ A+ KY Sbjct: 174 NQVELHPLNNQADLRAFCDAKQIKVEAWSPLGQGK----------LLSNPILSAIGAKYN 223 Query: 243 RSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 298 ++ AQ++LRW +Q+ +I IPKS+ RI +N +FDF E++ ++ALN N RY Sbjct: 224 KTAAQVILRWNIQKNLITIPKSVHRERIEENADIFDFELGAEDVMSIDALNTNSRY 279 >5Z6T-A nrPDB Length = 343 Score = 226 bits (575), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 123/307 (40%), Positives = 175/307 (57%), Gaps = 11/307 (3%) Query: 5 CVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDV 64 + L++G MP +G G WK + + A+ GYR D A Y NE +G +K+ + Sbjct: 28 SIKLNSGYDMPAVGFGCWKVDVDTCSEQIYRAIKTGYRLFDGAEDYANEKLVGAGVKKAI 87 Query: 65 GPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAF------ 118 G V RE+LF+TSKLWN HHP++VE AL +TL+DLQ++Y+DL+L+H+P F Sbjct: 88 DEG-IVKREDLFLTSKLWNNYHHPDNVEKALNRTLSDLQVDYVDLFLIHFPVTFKFVPLE 146 Query: 119 ERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV 178 E+ F Y+ ETWKALE LV G ++++G+SNF + D+L A++ Sbjct: 147 EKYPPGFYCGKGDNFDYEDVPILETWKALEKLVKAGKIRSIGVSNFPGALLLDLLRGATI 206 Query: 179 RPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSD----RAWRDPDEPVLLEEPVV 234 +P+VLQVE HPYL Q LI Q+RG+ VTAYS G R + L E + Sbjct: 207 KPSVLQVEHHPYLQQPRLIEFAQSRGIAVTAYSSFGPQSFVELNQGRALNTSPLFENETI 266 Query: 235 LALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNK 294 A+A K+G+SPAQ+LLRW QR + IPKS T R+L+N V F ++ + L+ Sbjct: 267 KAIAAKHGKSPAQVLLRWSSQRGIAIIPKSNTVPRLLENKDVNSFDLDEQDFADIAKLDI 326 Query: 295 NWRYIVP 301 N R+ P Sbjct: 327 NLRFNDP 333 >3KRB-A nrPDB Length = 334 Score = 225 bits (574), Expect = 2e-59, Method: Compositional matrix adjust. Identities = 124/303 (40%), Positives = 181/303 (59%), Gaps = 16/303 (5%) Query: 15 PLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE---DVGPGKAVP 71 P +G GTW++ P V+ AV+ AL GYRHIDCA +Y NE IG A + D G + Sbjct: 26 PRLGFGTWQAPPEAVQTAVETALMTGYRHIDCAYVYQNEEAIGRAFGKIFKDASSG--IK 83 Query: 72 REELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD--NPFPKNA 129 RE++++TSKLWN H PE V +KT++DLQ++YLDL+L+HWP AF R D + FPK+A Sbjct: 84 REDVWITSKLWNYNHRPELVREQCKKTMSDLQVDYLDLFLVHWPLAFVRNDVGDLFPKDA 143 Query: 130 DGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHP 189 +G + +TW+A+E LV +GLV+ +G+SN+ + D+L+ A ++P V Q+E HP Sbjct: 144 EGRAMLEKVPLADTWRAMEQLVEEGLVKHIGVSNYTVPLLADLLNYAKIKPLVNQIEIHP 203 Query: 190 YLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPD---EPVLLEEPVVLALAEKYGRSPA 246 + + + C G+ VTAYSP+G S RDP + V+LE + A+A+ G SP Sbjct: 204 WHPNDATVKFCLDNGIGVTAYSPMGGSYADPRDPSGTQKNVILECKTLKAIADAKGTSPH 263 Query: 247 QILLRWQVQR----KVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNA--LNKNWRYIV 300 + L W V++ IPKS TP+RI N K + S ++M +N LNK R+ Sbjct: 264 CVALAWHVKKWNTSMYSVIPKSQTPARIEANFKCTEVQLSDDDMDAINNIHLNKRIRFCD 323 Query: 301 PML 303 P + Sbjct: 324 PAI 326 >4GIE-A nrPDB Length = 290 Score = 218 bits (555), Expect = 3e-57, Method: Compositional matrix adjust. Identities = 113/295 (38%), Positives = 170/295 (57%), Gaps = 33/295 (11%) Query: 4 SCVLLHTGQKMPLIGLGTWKSEPGQVKA-AVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62 +CV LH +MP +GLG W+++ G A AV++A+ GYRHID A IY NE +G+ ++E Sbjct: 14 NCVTLHNSVRMPQLGLGVWRAQDGAETANAVRWAIEAGYRHIDTAYIYSNERGVGQGIRE 73 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 VPREE++VT+K+WN+ E A ++ L LEY+DLYL+HWP G Sbjct: 74 S-----GVPREEVWVTTKVWNSDQGYEKTLAAFERSRELLGLEYIDLYLIHWP-----GK 123 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAV 182 F +TWKALE L + V+A+G+SNF + ++ +RP V Sbjct: 124 KKFV---------------DTWKALEKLYEEKKVRAIGVSNFEPHHLTELFKSCKIRPMV 168 Query: 183 LQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYG 242 QVE HP Q L C+ + +TA+SPLGS +E +L+ V+ +A+K+ Sbjct: 169 NQVELHPLFQQRTLREFCKQHNIAITAWSPLGSG-------EEAGILKNHVLGEIAKKHN 221 Query: 243 RSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWR 297 +SPAQ+++RW +Q ++ IPKS RI +N V+DF + EEM+Q++ LN++ R Sbjct: 222 KSPAQVVIRWDIQHGIVTIPKSTNKGRIQENFNVWDFKLTEEEMRQIDELNEDKR 276 >1VBJ-A nrPDB Length = 281 Score = 214 bits (545), Expect = 4e-56, Method: Compositional matrix adjust. Identities = 115/292 (39%), Positives = 165/292 (56%), Gaps = 36/292 (12%) Query: 8 LHTGQKMPLIGLGTWKSEPG-QVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGP 66 L G MP++G G WK + G + + A +A+ GYRHID AAIY NE G A+ Sbjct: 14 LSNGVMMPVLGFGMWKLQDGNEAETATMWAIKSGYRHIDTAAIYKNEESAGRAI-----A 68 Query: 67 GKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFP 126 VPREELFVT+KLWN+ E A K++ L LEY+DLYL+HWP G + F Sbjct: 69 SCGVPREELFVTTKLWNSDQGYESTLSAFEKSIKKLGLEYVDLYLIHWP-----GKDKFI 123 Query: 127 KNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVE 186 +TWKA E L A V+A+G+SNF+ I+++L V P V Q+E Sbjct: 124 ---------------DTWKAFEKLYADKKVRAIGVSNFHEHHIEELLKHCKVAPMVNQIE 168 Query: 187 CHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPA 246 HP L Q L +C+++ + VTA+SPLG L+E+ + A+ KYG++ A Sbjct: 169 LHPLLNQKALCEYCKSKNIAVTAWSPLGQGH----------LVEDARLKAIGGKYGKTAA 218 Query: 247 QILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 298 Q++LRW++Q VI IPKS +RI +N +FDF + E+++ ++ +N RY Sbjct: 219 QVMLRWEIQAGVITIPKSGNEARIKENGNIFDFELTAEDIQVIDGMNAGHRY 270 >2BGQ-A nrPDB Length = 344 Score = 213 bits (542), Expect = 8e-56, Method: Compositional matrix adjust. Identities = 112/294 (38%), Positives = 169/294 (57%), Gaps = 14/294 (4%) Query: 7 LLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGP 66 +L +G MP +GLGTW++ + GYRH+D AA YG E E+G+ LK + Sbjct: 41 VLKSGHAMPAVGLGTWRAGSDTAHSVRTAITEAGYRHVDTAAEYGVEKEVGKGLKAAMEA 100 Query: 67 GKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFP 126 G + R++LFVTSK+W T PE V PAL TL DLQL+Y+DLY +HWP+ + G + P Sbjct: 101 G--IDRKDLFVTSKIWCTNLAPERVRPALENTLKDLQLDYIDLYHIHWPFRLKDGAH-MP 157 Query: 127 KNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVE 186 A + +D + WK +E LV GLV+ +G+ N+ +++ +L A + PAV Q+E Sbjct: 158 PEAGEVLEFD---MEGVWKEMENLVKDGLVKDIGVCNYTVTKLNRLLRSAKIPPAVCQME 214 Query: 187 CHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPA 246 HP +++ C+ G+ +TAYSPLGSS++ L +PVV +A K ++P Sbjct: 215 MHPGWKNDKIFEACKKHGIHITAYSPLGSSEKN--------LAHDPVVEKVANKLNKTPG 266 Query: 247 QILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 300 Q+L++W +QR IPKS RI +NI+VF + E+ K L ++ R + Sbjct: 267 QVLIKWALQRGTSVIPKSSKDERIKENIQVFGWEIPEEDFKVLCSIKDEKRVLT 320 >1QWK-A nrPDB Length = 317 Score = 206 bits (524), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 118/310 (38%), Positives = 176/310 (56%), Gaps = 24/310 (7%) Query: 2 AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 61 A + + L G +MP+IGLGTW+S P +V AVK A+ GYR ID A++Y NE IG A+K Sbjct: 4 ATASIKLSNGVEMPVIGLGTWQSSPAEVITAVKTAVKAGYRLIDTASVYQNEEAIGTAIK 63 Query: 62 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 E + G V REELF+T+K W + P +E LR++L LQLEY+DLYL H P AF Sbjct: 64 ELLEEG-VVKREELFITTKAWTHELAPGKLEGGLRESLKKLQLEYVDLYLAHMPAAFN-- 120 Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPA 181 D + ++ ++ W+ +A+ GL +A+G+SN+N+ QI L++ Sbjct: 121 --------DDMSEHIASPVEDVWRQFDAVYKAGLAKAVGVSNWNNDQISRALALGLTPVH 172 Query: 182 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRA-----------WRDPDEPVLLE 230 QVE H Y Q++ + C+ + VT+Y+ LGS R W P L+ Sbjct: 173 NSQVELHLYFPQHDHVDFCKKHNISVTSYATLGSPGRVNFTLPTGQKLDWAPA--PSDLQ 230 Query: 231 EPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLN 290 + VLALAEK ++PAQ+LLR+ + R +PKSI +RI +N +VFDF+ + E++ +L Sbjct: 231 DQNVLALAEKTHKTPAQVLLRYALDRGCAILPKSIQENRIKENFEVFDFSLTEEDIAKLE 290 Query: 291 ALNKNWRYIV 300 + R + Sbjct: 291 ESKNSQRLFL 300 >3D3F-A nrPDB Length = 275 Score = 204 bits (518), Expect = 5e-53, Method: Compositional matrix adjust. Identities = 122/295 (41%), Positives = 170/295 (57%), Gaps = 36/295 (12%) Query: 4 SCVLLHTGQKMPLIGLGTWKSEPG-QVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62 V LH G +MP GLG +K E G + +VK A+ GYR ID AAIY NE +G +KE Sbjct: 6 DTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNGYRSIDTAAIYKNEEGVGIGIKE 65 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 V REELF+TSK+WN E A K+L LQL+YLDLYL+HWP Sbjct: 66 -----SGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQLDYLDLYLIHWP------- 113 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAV 182 YK+TW+ALE L G ++A+G+SNF ++++L A ++P V Sbjct: 114 -------------GKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPMV 160 Query: 183 LQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYG 242 QVE HP L Q EL +C+ +G+++ A+SPL LL+ V+ +AEK+ Sbjct: 161 NQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQ----------LLDNEVLTQIAEKHN 210 Query: 243 RSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWR 297 +S AQ++LRW +Q V+ IPKSI RI++N +FDF S E+M +++ALNK+ R Sbjct: 211 KSVAQVILRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDER 265 >1MZR-A nrPDB Length = 296 Score = 199 bits (507), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 107/296 (36%), Positives = 165/296 (55%), Gaps = 37/296 (12%) Query: 4 SCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKED 63 + + L G MP +GLG W++ +V A++ AL VGYR ID AA Y NE +G+ALK Sbjct: 26 TVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKN- 84 Query: 64 VGPGKAVPREELFVTSKLWNTKH-HPEDVEPALRKTLADLQLEYLDLYLMHWPY-AFERG 121 +V REELF+T+KLWN H P + AL +L LQL+Y+DLYLMHWP A + Sbjct: 85 ----ASVNREELFITTKLWNDDHKRPRE---ALLDSLKKLQLDYIDLYLMHWPVPAID-- 135 Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPA 181 HY E WK + L +GL++++G+ NF + ++ V P Sbjct: 136 -----------------HYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPV 178 Query: 182 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKY 241 + Q+E HP + Q +L A ++ ++SPL + + ++ V+ LA+KY Sbjct: 179 INQIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKG--------VFDQKVIRDLADKY 230 Query: 242 GRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWR 297 G++PAQI++RW + ++ IPKS+TPSRI +N V+DF +E+ ++ L++ R Sbjct: 231 GKTPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKR 286 >1VP5-A nrPDB Length = 298 Score = 186 bits (473), Expect = 9e-48, Method: Compositional matrix adjust. Identities = 103/294 (35%), Positives = 164/294 (55%), Gaps = 30/294 (10%) Query: 1 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL 60 M V L+ G +MP++G G ++ P + + V A+ VGYR ID AA Y NE +G A+ Sbjct: 13 MQVPKVTLNNGVEMPILGYGVFQIPPEKTEECVYEAIKVGYRLIDTAASYMNEEGVGRAI 72 Query: 61 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 120 K + G V REELFVT+KLW + E + A K+L LQLEY+DLYL+H P+ Sbjct: 73 KRAIDEG-IVRREELFVTTKLWVSDVGYESTKKAFEKSLKKLQLEYIDLYLIHQPF---- 127 Query: 121 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP 180 GD C WKA+E + GLV+A+G+SNF ++ D++ + P Sbjct: 128 GD---------VHC--------AWKAMEEMYKDGLVRAIGVSNFYPDRLMDLMVHHEIVP 170 Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240 AV Q+E HP+ + E I + ++ A+ P + + + V+ ++AEK Sbjct: 171 AVNQIEIHPFYQRQEEIEFMRNYNIQPEAWGPFAEGRKN--------IFQNGVLRSIAEK 222 Query: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNK 294 YG++ AQ++LRW Q+ ++ IPK++ R+ +NI +FDF + E+M+++ L++ Sbjct: 223 YGKTVAQVILRWLTQKGIVAIPKTVRRERMKENISIFDFELTQEDMEKIATLDE 276 >4MHB-A nrPDB Length = 297 Score = 179 bits (454), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 98/290 (33%), Positives = 157/290 (54%), Gaps = 35/290 (12%) Query: 5 CVLLHTGQKMPLIGLGTWK-SEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKED 63 V L+ G MPL+G G ++ + + + AV A+ GYR ID AA Y NE ++G ALK Sbjct: 17 TVKLNNGIAMPLLGFGVFQMTNTAECERAVIDAIETGYRLIDTAASYQNETQVGNALKL- 75 Query: 64 VGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDN 123 + R+ELF+T+KLW + E + ++L LQL+Y+DLYL+H PY G Sbjct: 76 ----SGIARDELFITTKLWLQDTYYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHG-- 129 Query: 124 PFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVL 183 W+A+E L G ++A+G+SNF+ ++ D+++ + PAV Sbjct: 130 -------------------AWRAMEELHQAGKIRAIGVSNFHPDRLADLMAFNKIIPAVN 170 Query: 184 QVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGR 243 Q+E +P+ Q + Q+RG++ A++P L + PV+ A+ EKYG+ Sbjct: 171 QIEVNPFNQQLHAVPWMQSRGIQPEAWAPFAEGRNG--------LFQNPVLTAIGEKYGK 222 Query: 244 SPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALN 293 S Q++LRW QR ++ + KS+ R+ +NI + DF S E+M Q+ AL+ Sbjct: 223 SVGQVVLRWIFQRGIVSLAKSVRKGRMEENINILDFELSAEDMLQIAALD 272 >1A80-A nrPDB Length = 277 Score = 170 bits (430), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 98/289 (33%), Positives = 157/289 (54%), Gaps = 31/289 (10%) Query: 5 CVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDV 64 ++L+ G +P +G G +K P + AV+ AL VGYRHID AAIYGNE +G A+ Sbjct: 4 SIVLNDGNSIPQLGYGVFKVPPADTQRAVEEALEVGYRHIDTAAIYGNEEGVGAAIAA-- 61 Query: 65 GPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNP 124 + R++LF+T+KLWN +H ++ A+ ++LA L L+ +DLYL+HWP P Sbjct: 62 ---SGIARDDLFITTKLWNDRHDGDEPAAAIAESLAKLALDQVDLYLVHWP-------TP 111 Query: 125 FPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQ 184 N Y W+ + L A GL +++G+SN ++ I++ V PAV Q Sbjct: 112 AADN-----------YVHAWEKMIELRAAGLTRSIGVSNHLVPHLERIVAATGVVPAVNQ 160 Query: 185 VECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRS 244 +E HP Q E+ A +++ ++ PLG + EPV A A +G++ Sbjct: 161 IELHPAYQQREITDWAAAHDVKIESWGPLGQGKY-------DLFGAEPVT-AAAAAHGKT 212 Query: 245 PAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALN 293 PAQ +LRW +Q+ + PKS+ R+ +N+ VFDF + E+ ++A++ Sbjct: 213 PAQAVLRWHLQKGFVVFPKSVRRERLEENLDVFDFDLTDTEIAAIDAMD 261 >4IJC-A nrPDB Length = 344 Score = 168 bits (426), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 111/308 (36%), Positives = 173/308 (56%), Gaps = 29/308 (9%) Query: 8 LHTGQKMPLIGLGTWK--SEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVG 65 L+ G ++P +GLGT + + K AVK A+ GYRHID A Y EP +GEA+KE + Sbjct: 27 LNNGVRIPALGLGTANPHEKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKELLE 86 Query: 66 PGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNP- 124 G ++ RE+LF+T+K+W ++V+ +L ++L L LEY+DL L HWP FE+ +P Sbjct: 87 DG-SIKREDLFITTKVWPVLW--DEVDRSLNESLKALGLEYVDLLLQHWPLCFEKIKDPK 143 Query: 125 -------FPKNADGTICYDST-HYKETWKALEALV---AKGLVQALGLSNFNSRQIDDIL 173 P + G Y + Y ET+K LE + V+A+G+SNF+ ++ ++ Sbjct: 144 GISGLVKTPVDDSGKTMYAADGDYLETYKQLEKIYLDPNDHRVRAIGVSNFSIEYLERLI 203 Query: 174 SVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPV 233 V+P V QVE HP+L Q EL C + +TAYSPLGS P+ L+ P+ Sbjct: 204 KECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGA----PN----LKIPL 255 Query: 234 VLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALN 293 V LAEKY + +L+ + +++ I IP+S+ P RI +I+ T +E+++LN Sbjct: 256 VKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFASLT--KDELQELNDFG 313 Query: 294 KNW--RYI 299 + + R+I Sbjct: 314 EKYPVRFI 321 >4OTK-A nrPDB Length = 318 Score = 165 bits (417), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 100/296 (33%), Positives = 144/296 (48%), Gaps = 33/296 (11%) Query: 2 AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 61 AA + L+ MP++GLG + + + AV AL +G R ID A YGNE +G A+ Sbjct: 45 AAPSITLNDEHTMPVLGLGVAELSDDETERAVSAALEIGCRLIDTAYAYGNEAAVGRAIA 104 Query: 62 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 V REELFVT+KL + A R +L L L+Y+DLYL+HWP Sbjct: 105 -----ASGVAREELFVTTKLATPDQGFTRSQEACRASLDRLGLDYVDLYLIHWPAP---- 155 Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPA 181 P K Y + W + +G +++G+SNF + I++++ + V PA Sbjct: 156 --PVGK------------YVDAWGGMIQSRGEGHARSIGVSNFTAENIENLIDLTFVTPA 201 Query: 182 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKY 241 V Q+E HP L Q+EL + +Y PL LL+ P V ++A +Y Sbjct: 202 VNQIELHPLLNQDELRKANAQHTVVTQSYCPLALGR----------LLDNPTVTSIASEY 251 Query: 242 GRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWR 297 ++PAQ+LLRW +Q + +S P RI N VFDF + E M L LN R Sbjct: 252 VKTPAQVLLRWNLQLGNAVVVRSARPERIASNFDVFDFELAAEHMDALGGLNDGTR 307 >3UP8-A nrPDB Length = 298 Score = 157 bits (396), Expect = 8e-39, Method: Compositional matrix adjust. Identities = 89/294 (30%), Positives = 160/294 (54%), Gaps = 36/294 (12%) Query: 10 TGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKA 69 G +P +G GT++ +V + AL +G+RH+D A IYGNE E+GEA+++ Sbjct: 30 NGANIPALGFGTFRMSGAEVLRILPQALKLGFRHVDTAQIYGNEAEVGEAIQK-----SG 84 Query: 70 VPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNA 129 +PR ++F+T+K+W + + ++ ++L L+ +++DL L+HWP + D P Sbjct: 85 IPRADVFLTTKVWVDNYRHDAFIASVDESLRKLRTDHVDLLLLHWPGS----DVPMA--- 137 Query: 130 DGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHP 189 E AL + G V+ +G+SNFN+ Q+++ ++ A QVE HP Sbjct: 138 ------------ERIGALNEVRNAGKVRHIGISNFNTTQMEEAARLSDAPIATNQVEYHP 185 Query: 190 YLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQIL 249 YL Q +++ + G+ +T+Y + + + P +P+L E + ++G++ AQ+ Sbjct: 186 YLDQTKVLQTARRLGMSLTSYYAMANG----KVPADPLLTE------IGGRHGKTAAQVA 235 Query: 250 LRWQVQRK-VICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNK-NWRYIVP 301 LRW VQ++ VI + K+ T +R+ +N +FDF + EEM + L + N R + P Sbjct: 236 LRWLVQQQDVIVLSKTATEARLKENFAIFDFALTREEMAAVRELARPNGRIVNP 289 >3WG6-A nrPDB Length = 307 Score = 144 bits (362), Expect = 7e-35, Method: Compositional matrix adjust. Identities = 101/313 (32%), Positives = 154/313 (49%), Gaps = 45/313 (14%) Query: 1 MAASCVLLHTGQKMPLIGLGTW--------KSEPGQVKAAVKYALSVGYRHIDCAAIYGN 52 +A L G K+P + GT Q+ ++ AL G+RHID A IYG Sbjct: 6 LAGKEFKLSNGNKIPAVAFGTGTKYFKRGHNDLDKQLIGTLELALRSGFRHIDGAEIYGT 65 Query: 53 EPEIGEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVE--------PALRKTLADLQL 104 EIG ALK +VG + R+++F+T K +N+ +H D + AL+ L DL L Sbjct: 66 NKEIGIALK-NVG----LNRKDVFITDK-YNSGNHTYDGKHSKHQNPYNALKADLEDLGL 119 Query: 105 EYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNF 164 EY+DLYL+H+PY E+ + +D E W+ LE +GL + +G+SNF Sbjct: 120 EYVDLYLIHFPYISEK-----------SHGFDLV---EAWRYLERAKNEGLARNIGVSNF 165 Query: 165 NSRQIDDILSVASVR-PAVLQVECHPYLAQNE--LIAHCQARGLEVTAYSPLGSSDRAWR 221 + IL + P V Q+E YL ++ + Q +G+ + AY PLG + Sbjct: 166 TIENLKSILDANTDSIPVVNQIEFSAYLQDQTPGIVEYSQQQGILIEAYGPLGPITQGRP 225 Query: 222 DPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTF 281 P + VL + L+EKY R+ QILLRW +QR ++ I + RI +++FDF Sbjct: 226 GPLDKVLSK------LSEKYKRNEGQILLRWVLQRGILPITTTSKEERINDVLEIFDFEL 279 Query: 282 SPEEMKQLNALNK 294 E+ Q+ + K Sbjct: 280 DKEDEDQITKVGK 292 >4H8N-A nrPDB Length = 310 Score = 126 bits (316), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 85/270 (31%), Positives = 142/270 (52%), Gaps = 41/270 (15%) Query: 36 ALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAVPREELFVTSKL---WNT-KHHPEDV 91 L +G+RHID A Y + E+GEALK VPRE+++VT+K W + K + + Sbjct: 52 GLKLGFRHIDTAEAYNTQKEVGEALKR-----TDVPREDIWVTTKYSPGWGSIKAYSKSP 106 Query: 92 EPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTH---YKETWKALE 148 ++ K LA L ++Y+DL+L+H P+ + TH ++ W+AL Sbjct: 107 SDSIDKALAQLGVDYVDLFLIHSPF----------------FTTEQTHGYTLEQAWEALV 150 Query: 149 ALVAKGLVQALGLSNFNSRQIDDILSVA---SVRPAVLQVECHPYLAQNE---LIAHCQA 202 G V+ +G+SN ++ + + + P V Q+E HP+L QN+ ++ CQ Sbjct: 151 EAKKAGKVREIGISNAAIPHLEKLFAASPSPEYYPVVNQIEFHPFL-QNQSKNIVRFCQE 209 Query: 203 RGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIP 262 G+ V A+SPL R E L E + LAEKY ++ AQ+LLR+ +QR ++ + Sbjct: 210 HGILVEAFSPLAPLARV-----ETNALAE-TLKRLAEKYKKTEAQVLLRYTLQRGILPVT 263 Query: 263 KSITPSRILQNIKVFDFTFSPEEMKQLNAL 292 S SR+ +++ +FDF + EE+ ++N + Sbjct: 264 TSSKESRLKESLNLFDFELTDEEVNEINKI 293 >1PZ1-A nrPDB Length = 333 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 80/333 (24%), Positives = 142/333 (42%), Gaps = 76/333 (22%) Query: 10 TGQKMPLIGLGTWK--------SEPGQVKAAVKYALSVGYRHIDCAAIYG---NEPEIGE 58 TG + IGLGTW ++ ++ AL G ID A YG +E +G+ Sbjct: 9 TGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAALDQGITLIDTAPAYGFGQSEEIVGK 68 Query: 59 ALKEDVGPGKAVPREELFVTSKL---W---------NTKHHPEDVEPALRKTLADLQLEY 106 A+KE + R+++ + +K W N E+VE +L++ LQ +Y Sbjct: 69 AIKE------YMKRDQVILATKTALDWKNNQLFRHANRARIVEEVENSLKR----LQTDY 118 Query: 107 LDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNS 166 +DLY +HWP D P +ET + ++ L G ++A+G+SNF+ Sbjct: 119 IDLYQVHWP------DPLVP-------------IEETAEVMKELYDAGKIRAIGVSNFSI 159 Query: 167 RQIDDILSVA---SVRPAV------LQVECHPYLAQNE---LIAHCQARGL---EVTAYS 211 Q+D +VA +++P ++ PY N+ L+ RGL ++T Sbjct: 160 EQMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEEY 219 Query: 212 PLGSSDRAWRDP--DEPVLLEEPVVLALAEK-----YGRSPAQILLRWQVQR--KVICIP 262 D DP +P E + +K YG+S + +RW + + I + Sbjct: 220 TFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADIALW 279 Query: 263 KSITPSRILQNIKVFDFTFSPEEMKQLNALNKN 295 + P ++ ++ +T + E+ K +N + +N Sbjct: 280 GARKPGQLEALSEITGWTLNSEDQKDINTILEN 312 >1LQA-A nrPDB Length = 346 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 81/348 (23%), Positives = 143/348 (41%), Gaps = 64/348 (18%) Query: 9 HTGQKMPLIGLGTW----KSEPGQVKAAVKYALSVGYRHIDCAAIYGN--EPEIGEALKE 62 H+ ++ +GLGT ++ A + YA++ G ID A +Y PE + Sbjct: 8 HSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQGLTET 67 Query: 63 DVGP--GKAVPREELFVTSKLWN-TKHHPEDVEP-----------ALRKTLADLQLEYLD 108 VG K RE+L + SK+ ++++ + + P AL +L LQ +YLD Sbjct: 68 YVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRLQTDYLD 127 Query: 109 LYLMHWPYAFERGDNPFPKNADGTICYDSTHYK------ETWKALEALVAKGLVQALGLS 162 LY +HWP +R P N G + Y T +T AL G ++ +G+S Sbjct: 128 LYQVHWP---QR-----PTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVS 179 Query: 163 NFNSRQIDDILSVASVR--PAVLQVECHPYLAQNE-----LIAHCQARGLEVTAYSPLGS 215 N + + L +A P ++ ++ +PY N L Q G+E+ AYS LG Sbjct: 180 NETAFGVMRYLHLADKHDLPRIVTIQ-NPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGF 238 Query: 216 S--------------------DRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQ 255 R R E + +A ++G PAQ+ L + + Sbjct: 239 GTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMALAFVRR 298 Query: 256 RKVIC--IPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVP 301 + + + + T ++ NI+ S + + ++ A+++ + Y P Sbjct: 299 QPFVASTLLGATTMDQLKTNIESLHLELSEDVLAEIEAVHQVYTYPAP 346 >1PYF-A nrPDB Length = 312 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 75/326 (23%), Positives = 131/326 (40%), Gaps = 83/326 (25%) Query: 17 IGLGT-----------WKSEPGQVKAAVKYALSVGYRHIDCAAIYG---NEPEIGEALKE 62 IGLGT E G K V+ A+ G +D A IYG +E IGE L+E Sbjct: 16 IGLGTNAVGGHNLYPNLNEETG--KELVREAIRNGVTMLDTAYIYGIGRSEELIGEVLRE 73 Query: 63 DVGPGKAVPREELFVTSKLWNTK--------HHPEDVEPALRKTLADLQLEYLDLYLMHW 114 RE++ + +K + K + P+ ++ ++ ++L L +Y+DL+ +H+ Sbjct: 74 -------FNREDVVIATKAAHRKQGNDFVFDNSPDFLKKSVDESLKRLNTDYIDLFYIHF 126 Query: 115 PYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQI----- 169 P D PK+ E AL + G ++++G+SNF+ Q+ Sbjct: 127 P------DEHTPKD-------------EAVNALNEMKKAGKIRSIGVSNFSLEQLKEANK 167 Query: 170 DDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLL 229 D ++ V +L E A+ + + + Y PL S A + ++ Sbjct: 168 DGLVDVLQGEYNLLNRE-----AEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTEDTTFP 222 Query: 230 EEPV---------------------VLALAEKYGRSPAQILLRWQVQRKV--ICIPKSIT 266 E + + +AEK+ I+L W + R I IP + Sbjct: 223 EGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDILIPGAKR 282 Query: 267 PSRILQNIKVFDFTFSPEEMKQLNAL 292 +++ NIK D T S E++ ++ L Sbjct: 283 ADQLIDNIKTADVTLSQEDISFIDKL 308 >3N6Q-A nrPDB Length = 346 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 72/333 (21%), Positives = 141/333 (42%), Gaps = 76/333 (22%) Query: 10 TGQKMPLIGLGTWKSEPGQV------KAAVKYALSVGYRHIDCAAIYG-----NEPEIGE 58 +G ++P + LG W + G V +A ++ A +G H D A YG E G Sbjct: 21 SGLRLPALSLGLWHN-FGHVNALESQRAILRKAFDLGITHFDLANNYGPPPGSAEENFGR 79 Query: 59 ALKEDVGPGKAVPREELFVTSK----LW----NTKHHPEDVEPALRKTLADLQLEYLDLY 110 L+ED A R+EL +++K +W + + + +L ++L + LEY+D++ Sbjct: 80 LLREDF----AAYRDELIISTKAGYDMWPGPYGSGGSRKYLLASLDQSLKRMGLEYVDIF 135 Query: 111 LMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQID 170 H R D ++T +ET AL V G +G+S+++ + Sbjct: 136 YSH------RVD-------------ENTPMEETASALAHAVQSGKALYVGISSYSPERTQ 176 Query: 171 DILSVASVRPAVLQVECHPY------LAQNELIAHCQARGLEVTAYSPLGSS-------- 216 ++ + L + Y + ++ L+ Q G+ A++PL Sbjct: 177 KMVELLREWKIPLLIHQPSYNLLNRWVDKSGLLDTLQNNGVGCIAFTPLAQGLLTGKYLN 236 Query: 217 -----DRAWRDPDE-----PVLLEEPVVLAL------AEKYGRSPAQILLRWQVQ--RKV 258 R R+ ++ P +L E + +L A++ G+S AQ+ L W ++ R Sbjct: 237 GIPQDSRMHREGNKVRGLTPKMLTEANLNSLRLLNEMAQQRGQSMAQMALSWLLKDDRVT 296 Query: 259 ICIPKSITPSRILQNIKVF-DFTFSPEEMKQLN 290 + + ++ +N++ + TFS +E+ Q++ Sbjct: 297 SVLIGASRAEQLEENVQALNNLTFSTKELAQID 329 >3EB3-A nrPDB Length = 327 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 48/200 (24%), Positives = 84/200 (42%), Gaps = 37/200 (18%) Query: 7 LLHTGQKMPLIGLGTWKSEPGQV-----KAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 61 L +G ++ +GLGTW + GQ+ + + A G D A +Y E + Sbjct: 8 LGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGK--AEVVL 65 Query: 62 EDVGPGKAVPREELFVTSKLW-NTKHHPE------DVEPALRKTLADLQLEYLDLYLMHW 114 ++ K R L +T+K++ K E + L+ +L LQLEY+D+ Sbjct: 66 GNIIKKKGWRRSSLVITTKIFAGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVF--- 122 Query: 115 PYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILS 174 + P P +T +ET +A+ ++ +G+ G S ++S +I + S Sbjct: 123 ------ANRPDP----------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYS 166 Query: 175 VAS----VRPAVLQVECHPY 190 VA + P Q E H + Sbjct: 167 VARQFNLIPPICEQAEYHMF 186 >1GVE-A nrPDB Length = 327 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 50/195 (25%), Positives = 82/195 (42%), Gaps = 30/195 (15%) Query: 31 AAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAVPREELFVTSK---LWNTKHH 87 A+V+ L G+ ID A +Y N E + D+G G ++ + +K ++ Sbjct: 26 ASVRAFLQRGHTEIDTAFVYANGQS--ETILGDLGLGLGRSGCKVKIATKAAPMFGKTLK 83 Query: 88 PEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKAL 147 P DV L +L LQ +DL+ +H+P D+ P +ET +A Sbjct: 84 PADVRFQLETSLKRLQCPRVDLFYLHFP------DHGTP-------------IEETLQAC 124 Query: 148 EALVAKGLVQALGLSNFNSRQIDDILSVAS----VRPAVLQVECHPYLAQ--NELIAHCQ 201 L +G LGLSN+ S ++ +I ++ + P V Q + Q EL + Sbjct: 125 HQLHQEGKFVELGLSNYVSWEVAEICTLCKKNGWIMPTVYQGMYNAITRQVETELFPCLR 184 Query: 202 ARGLEVTAYSPLGSS 216 GL A++PL Sbjct: 185 HFGLRFYAFNPLAGG 199 >1OG6-A nrPDB Length = 298 Score = 38.1 bits (87), Expect = 0.006, Method: Compositional matrix adjust. Identities = 48/185 (25%), Positives = 68/185 (36%), Gaps = 37/185 (20%) Query: 19 LGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGN---EPEIGEALK---------EDVGP 66 L W Q+ + ++ L +G +D A IYG E GEALK E V Sbjct: 24 LMDWNMSARQLVSFIEEHLDLGVTTVDHADIYGGYQCEAAFGEALKLAPHLRERMEIVSK 83 Query: 67 G--KAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNP 124 REE + + + H + E ++L +L ++LDL L+H P D Sbjct: 84 CGIATTAREENVIGHYITDRDHIIKSAE----QSLINLATDHLDLLLIHRPDPLMDAD-- 137 Query: 125 FPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQ 184 E A + L G V+ G+SNF Q + S A Q Sbjct: 138 -----------------EVADAFKHLHQSGKVRHFGVSNFTPAQFALLQSRLPFTLATNQ 180 Query: 185 VECHP 189 VE P Sbjct: 181 VEISP 185 >4R9O-A nrPDB Length = 301 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 60/249 (24%), Positives = 95/249 (38%), Gaps = 38/249 (15%) Query: 19 LGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGN---EPEIGEALKEDVGPG-----KAV 70 L W Q+ + ++ L +G +D A IYG E GEAL + P + V Sbjct: 27 LMDWNMSARQLVSFIEEHLDLGVTTVDHADIYGGYQCEAAFGEALT--LAPHLREKLQIV 84 Query: 71 PREELFVTSKLWNTKHH----PEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFP 126 + + T++ N H + + ++L +L +YLD+ L+H P D+ Sbjct: 85 TKCGIATTARAENKLGHYITDRRHIILSAEQSLKNLATDYLDMLLIHRPDPLMDADD--- 141 Query: 127 KNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVE 186 +A + L G V+ G+SNF Q + S A QVE Sbjct: 142 ----------------VAEAFQHLHQSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQVE 185 Query: 187 CHPY---LAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGR 243 P L + + Q + A+S LG R + D L +E V+A E Sbjct: 186 ISPVHQPLLLDGTLDQLQQLRIRPMAWSCLGGG-RLFNDEAYQPLRQELSVIA-QELNAS 243 Query: 244 SPAQILLRW 252 S Q++ W Sbjct: 244 SIEQVVYAW 252 >2BP1-A nrPDB Length = 360 Score = 35.4 bits (80), Expect = 0.032, Method: Compositional matrix adjust. Identities = 39/150 (26%), Positives = 62/150 (41%), Gaps = 26/150 (17%) Query: 72 REELFVTSKLWNTKH-HPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNAD 130 R ++ + W+ K P+ V L +L LQ +DL+ +H P D+ P Sbjct: 100 RVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAP------DHGTP---- 149 Query: 131 GTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS----VRPAVLQVE 186 +ET A + L +G LGLSN+ S ++ +I ++ + P V Q Sbjct: 150 ---------VEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGM 200 Query: 187 CHPYLAQ--NELIAHCQARGLEVTAYSPLG 214 + Q EL + GL AY+PL Sbjct: 201 YNATTRQVETELFPCLRHFGLRFYAYNPLA 230 >2C91-A nrPDB Length = 338 Score = 34.3 bits (77), Expect = 0.069, Method: Compositional matrix adjust. Identities = 36/135 (26%), Positives = 56/135 (41%), Gaps = 25/135 (18%) Query: 88 PEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKAL 147 P+ + L +L LQ +DL+ +H P D+ ST +ET A Sbjct: 95 PDSIRSQLETSLKRLQCPRVDLFYLHAP------DH-------------STPVEETLCAC 135 Query: 148 EALVAKGLVQALGLSNFNSRQIDDILSVAS----VRPAVLQVECHPYLAQ--NELIAHCQ 201 L +G LGLSN+ S ++ +I ++ + P V Q + Q EL+ + Sbjct: 136 HQLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVEAELLPCLR 195 Query: 202 ARGLEVTAYSPLGSS 216 GL AY+PL Sbjct: 196 HFGLRFYAYNPLAGG 210 >2CLP-A nrPDB Length = 347 Score = 32.7 bits (73), Expect = 0.21, Method: Compositional matrix adjust. Identities = 35/142 (24%), Positives = 58/142 (40%), Gaps = 25/142 (17%) Query: 81 LWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHY 140 L+ P+ + L +L LQ +DL+ +H P D+ ST Sbjct: 97 LFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMP------DH-------------STPV 137 Query: 141 KETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS----VRPAVLQVECHPYLAQ--N 194 +ET +A L +G LGLSN+ + ++ +I ++ + P V Q + Q Sbjct: 138 EETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVET 197 Query: 195 ELIAHCQARGLEVTAYSPLGSS 216 EL + GL A++PL Sbjct: 198 ELFPCLRHFGLRFYAFNPLAGG 219 >5XKX-A nrPDB Length = 407 Score = 32.0 bits (71), Expect = 0.35, Method: Compositional matrix adjust. Identities = 29/101 (28%), Positives = 48/101 (47%), Gaps = 19/101 (18%) Query: 40 GYRHIDCAAIYGNEPEIGEALKEDVGPGKAVPREELFVTSKLWNTK-----HHPEDVEPA 94 GY + + +GN I E E VG E+ +T++L+NT HHP+++ Sbjct: 222 GYLYAEVMGPWGN-LRIKEIDGEKVGA-------EIGMTAQLFNTSYPYHYHHPQEIYMT 273 Query: 95 LRKTLADLQLEYLDLYLMHW---PYAFERGDNPFPKNADGT 132 L K Q +++ +MHW + +R DN + N DG+ Sbjct: 274 LTKPQCIDQNKHM---VMHWDNNQFKQKRSDNGWTVNIDGS 311 >3EC2-A nrPDB Length = 180 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 13/28 (46%), Positives = 19/28 (67%) Query: 262 PKSITPSRILQNIKVFDFTFSPEEMKQL 289 PK+++ +R L I+VF F+PEE K L Sbjct: 14 PKNVSQNRALLTIRVFVHNFNPEEGKGL 41 >5M0X-A nrPDB Length = 575 Score = 28.9 bits (63), Expect = 3.2, Method: Compositional matrix adjust. Identities = 20/68 (29%), Positives = 29/68 (42%), Gaps = 3/68 (4%) Query: 187 CHPYLA--QNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRS 244 HP+ A EL+A+ + +E + PL DP+ P+LLE+ L E R Sbjct: 144 AHPFFAVEDGELVAYLEYFDVEFDDFVPL-EPLVVLEDPNTPLLLEKYAELVGMENNARV 202 Query: 245 PAQILLRW 252 P W Sbjct: 203 PKHTPTGW 210 >3PS9-A nrPDB Length = 676 Score = 28.5 bits (62), Expect = 3.9, Method: Compositional matrix adjust. Identities = 31/134 (23%), Positives = 50/134 (37%), Gaps = 11/134 (8%) Query: 170 DDILSVASVRPAVLQ--VECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPV 227 DD + S++PA L+ E P + + GLE T Y LG + R P+ P Sbjct: 6 DDKMKHYSIQPANLEFNAEGTPVSRDFDDVYFSNDNGLEETRYVFLGGNQLEVRFPEHP- 64 Query: 228 LLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMK 287 P+ + +G + L WQ + + P LQ + F P Sbjct: 65 ---HPLFVVAESGFG-TGLNFLTLWQAFDQF----REAHPQAQLQRLHFISFEKFPLTRA 116 Query: 288 QLNALNKNWRYIVP 301 L +++W + P Sbjct: 117 DLALAHQHWPELAP 130 >2Y4N-A nrPDB Length = 437 Score = 27.7 bits (60), Expect = 6.5, Method: Compositional matrix adjust. Identities = 24/91 (26%), Positives = 39/91 (42%), Gaps = 15/91 (16%) Query: 19 LGTWKSEP--GQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAVPREELF 76 +G + +EP ++ A++ + ID IYG L E +GPG A E Sbjct: 214 IGIFGAEPWTNDMRVAIEQRMG-----IDAVDIYG--------LSEVMGPGVASECVETK 260 Query: 77 VTSKLWNTKHHPEDVEPALRKTLADLQLEYL 107 +W +PE ++P + L D +L L Sbjct: 261 DGPTIWEDHFYPEIIDPETGEVLPDGELGEL 291 >4EXA-A nrPDB Length = 292 Score = 27.7 bits (60), Expect = 7.4, Method: Compositional matrix adjust. Identities = 46/181 (25%), Positives = 70/181 (38%), Gaps = 54/181 (29%) Query: 10 TGQKMPLIGLGTWK-------------SEPGQVKAAVKYALS--VGYRHIDCAAIYGNEP 54 TG + +GLGT K + P +AA AL+ +G ID A YG Sbjct: 38 TGLAVSPLGLGTVKFGRDQGVKYPSGFTIPDDREAADLLALARDLGINLIDTAPAYGRS- 96 Query: 55 EIGEALKEDVGPGKAVPREELFVTSKL------------WNTKHHPEDVEPALRKTLADL 102 +E +GP RE + SK+ ++ H VE +L++ L Sbjct: 97 ------EERLGPLLRGQREHWVIVSKVGEEFVDGQSVFDFSAAHTRRSVERSLKR----L 146 Query: 103 QLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLS 162 + + ++L L+H +DG D E + L AL +GL+ A GLS Sbjct: 147 ETDRIELVLVH---------------SDGN-DLDILENSEVYPTLAALKREGLIGAYGLS 190 Query: 163 N 163 Sbjct: 191 G 191 >4PAF-A nrPDB Length = 334 Score = 27.3 bits (59), Expect = 9.7, Method: Compositional matrix adjust. Identities = 32/111 (28%), Positives = 48/111 (43%), Gaps = 9/111 (8%) Query: 3 ASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAA-IYG-NEPEIGEAL 60 A +L+ P++GL + + G A + +H+D +Y EPE +AL Sbjct: 224 ADTILISNHMMFPMVGLISARVYAGMSDADKAMISELMAKHVDSTLDVYMVKEPEWTDAL 283 Query: 61 KEDVGPGKAVPR-EELFVTSKL--WNTKHHPEDVE-PALRKTLADLQLEYL 107 + GK R ++ F + W T + P LRKT ADLQ E L Sbjct: 284 TK---VGKTFKRVDQSFFGDAIAQWETIWADKAPSLPELRKTAADLQAENL 331 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2ALR-A nrPDB 511 e-145 1HQT-A nrPDB 507 e-144 4GAC-A nrPDB 504 e-143 1ZUA-X nrPDB 458 e-129 4JQA-A nrPDB 453 e-128 1Q5M-A nrPDB 448 e-126 2FVL-A nrPDB 446 e-126 5JM5-A nrPDB 446 e-126 3G1R-A nrPDB 437 e-123 2HE8-A nrPDB 435 e-122 1DLA-A nrPDB 434 e-122 3RX4-A nrPDB 434 e-122 1AFS-A nrPDB 431 e-121 5UXF-A nrPDB 430 e-121 1C9W-A nrPDB 422 e-118 1FRB-A nrPDB 419 e-118 4HBK-A nrPDB 417 e-117 3O3R-A nrPDB 415 e-116 5ZCM-A nrPDB 395 e-110 3H7U-A nrPDB 392 e-110 5Z6T-A nrPDB 392 e-109 5JH1-A nrPDB 391 e-109 1K8C-A nrPDB 386 e-108 3WCZ-A nrPDB 377 e-105 4GIE-A nrPDB 364 e-101 3H7R-A nrPDB 364 e-101 1VBJ-A nrPDB 361 e-100 3KRB-A nrPDB 361 e-100 4F40-A nrPDB 360 e-100 2BGQ-A nrPDB 356 5e-99 1QWK-A nrPDB 349 1e-96 1VP5-A nrPDB 348 2e-96 1MZR-A nrPDB 337 3e-93 4MHB-A nrPDB 328 2e-90 3D3F-A nrPDB 328 3e-90 4OTK-A nrPDB 315 1e-86 4IJC-A nrPDB 311 4e-85 1A80-A nrPDB 303 6e-83 3UP8-A nrPDB 298 3e-81 3WG6-A nrPDB 266 1e-71 4H8N-A nrPDB 253 6e-68 1LQA-A nrPDB 214 4e-56 1PYF-A nrPDB 200 9e-52 1PZ1-A nrPDB 199 2e-51 3N6Q-A nrPDB 190 9e-49 3EB3-A nrPDB 177 5e-45 1GVE-A nrPDB 151 3e-37 Sequences not found previously or not previously below threshold: 2CLP-A nrPDB 142 3e-34 2BP1-A nrPDB 134 5e-32 2C91-A nrPDB 134 6e-32 4R9O-A nrPDB 118 2e-27 1OG6-A nrPDB 109 2e-24 4EXA-A nrPDB 73 2e-13 4EHI-A nrPDB 30 1.1 4BKP-A nrPDB 30 1.5 5ZF1-A nrPDB 30 1.6 4FO0-A nrPDB 30 1.9 4NPH-A nrPDB 29 2.8 5GJU-A nrPDB 29 3.1 4YWJ-A nrPDB 29 3.4 3IVU-A nrPDB 28 3.9 3MMA-A nrPDB 28 4.0 2BS2-A nrPDB 28 4.3 4WO8-A nrPDB 28 4.6 3Q3N-A nrPDB 28 4.9 1JPH-A nrPDB 28 6.3 5H82-A nrPDB 28 7.9 4P22-A nrPDB 28 8.0 6F0K-D nrPDB 28 8.3 >2ALR-A nrPDB Length = 324 Score = 511 bits (1317), Expect = e-145, Method: Composition-based stats. Identities = 324/324 (100%), Positives = 324/324 (100%) Query: 2 AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 61 AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK Sbjct: 1 AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 60 Query: 62 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG Sbjct: 61 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 120 Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPA 181 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPA Sbjct: 121 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPA 180 Query: 182 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKY 241 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKY Sbjct: 181 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKY 240 Query: 242 GRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVP 301 GRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVP Sbjct: 241 GRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVP 300 Query: 302 MLTVDGKRVPRDAGHPLYPFNDPY 325 MLTVDGKRVPRDAGHPLYPFNDPY Sbjct: 301 MLTVDGKRVPRDAGHPLYPFNDPY 324 >1HQT-A nrPDB Length = 326 Score = 507 bits (1306), Expect = e-144, Method: Composition-based stats. Identities = 304/325 (93%), Positives = 318/325 (97%) Query: 1 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL 60 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAA+KYAL+VGYRHIDCAAI+GNE EIGEAL Sbjct: 2 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAIKYALTVGYRHIDCAAIFGNELEIGEAL 61 Query: 61 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 120 +E VGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER Sbjct: 62 QETVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 121 Query: 121 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP 180 GDNPFPKNADGTI YD+THYK+TWKALEALVAKGLV+ALGLSNF+SRQIDD+LSVASVRP Sbjct: 122 GDNPFPKNADGTIRYDATHYKDTWKALEALVAKGLVRALGLSNFSSRQIDDVLSVASVRP 181 Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDP+EPVLLEEPVV ALAEK Sbjct: 182 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPNEPVLLEEPVVQALAEK 241 Query: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 300 Y RSPAQILLRWQVQRKVICIPKS+TPSRI QNI+VFDFTFSPEEMKQL+ALNKN R+IV Sbjct: 242 YNRSPAQILLRWQVQRKVICIPKSVTPSRIPQNIQVFDFTFSPEEMKQLDALNKNLRFIV 301 Query: 301 PMLTVDGKRVPRDAGHPLYPFNDPY 325 PMLTVDGKRVPRDAGHPLYPFNDPY Sbjct: 302 PMLTVDGKRVPRDAGHPLYPFNDPY 326 >4GAC-A nrPDB Length = 324 Score = 504 bits (1299), Expect = e-143, Method: Composition-based stats. Identities = 302/324 (93%), Positives = 313/324 (96%) Query: 2 AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 61 AS VLLHTGQKMPLIGLGTWKSEPGQVKAA+K+ALS GYRHIDCA++YGNE EIGEALK Sbjct: 1 TASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALK 60 Query: 62 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 E VG GKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG Sbjct: 61 ESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 120 Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPA 181 DNPFPKNADGT+ YDSTHYKETWKALE LVAKGLV+ALGLSNFNSRQIDD+LSVASVRPA Sbjct: 121 DNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPA 180 Query: 182 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKY 241 VLQVECHPYLAQNELIAHC ARGLEVTAYSPLGSSDRAWR PDEPVLLEEPVVLALAEK+ Sbjct: 181 VLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKH 240 Query: 242 GRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVP 301 GRSPAQILLRWQVQRKVICIPKSI PSRILQNI+VFDFTFSPEEMKQL+ALNKNWRYIVP Sbjct: 241 GRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVP 300 Query: 302 MLTVDGKRVPRDAGHPLYPFNDPY 325 M+TVDGKRVPRDAGHPLYPFNDPY Sbjct: 301 MITVDGKRVPRDAGHPLYPFNDPY 324 >1ZUA-X nrPDB Length = 317 Score = 458 bits (1179), Expect = e-129, Method: Composition-based stats. Identities = 159/325 (48%), Positives = 217/325 (66%), Gaps = 12/325 (3%) Query: 3 ASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62 A+ V L T KMP++GLGTWKS G+VK AVK A+ GYRHIDCA +Y NE E+GEA++E Sbjct: 3 ATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQE 62 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + KAV RE+LF+ SKLW T V A KTL DL+L YLD+YL+HWP F+ GD Sbjct: 63 KIQE-KAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGD 121 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR--P 180 + FPK+ G + + W+A+E LV +GLV+ALG+SNF+ QI+ +L+ ++ P Sbjct: 122 DLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKP 181 Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240 QVECHPYL Q +LI +C ++G+ VTAYSPLGS DR W P++P LLE+P + +A K Sbjct: 182 VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK 241 Query: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 300 + ++ AQ+L+R+ +QR VI IPKS+TP+RI++NI+VFDF S EEM + + N+NWR Sbjct: 242 HKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACN 301 Query: 301 PMLTVDGKRVPRDAGHPLYPFNDPY 325 V + + YPFN Y Sbjct: 302 ---------VLQSSHLEDYPFNAEY 317 >4JQA-A nrPDB Length = 331 Score = 453 bits (1166), Expect = e-128, Method: Composition-based stats. Identities = 138/327 (42%), Positives = 206/327 (62%), Gaps = 16/327 (4%) Query: 5 CVLLHTGQKMPLIGLGTWKS---EPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 61 CV L+ G MP++G GT+ + AVK A+ G+ HID A +Y NE ++G A++ Sbjct: 7 CVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIR 66 Query: 62 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 + G V RE++F TSKLW+ H PE V PAL ++L +LQL+Y+DLYL+H+P + + G Sbjct: 67 SKIADGS-VKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPG 125 Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR-- 179 + PK+ +G I +D+ TW+A+E GL +++G+SNFN R ++ IL+ ++ Sbjct: 126 EEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYK 185 Query: 180 PAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDR-AWRDPDEPVLLEEPVVLALA 238 P QVECHPY Q +L+ C+++ + + AYS LGS W DP+ PVLLE+PV+ ALA Sbjct: 186 PVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALA 245 Query: 239 EKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 298 +K+ R+PA I LR+Q+QR V+ + KS RI QN++VF+F + EEMK ++ LN+N RY Sbjct: 246 KKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRY 305 Query: 299 IVPMLTVDGKRVPRDAGHPLYPFNDPY 325 + + AG P YPF+D Y Sbjct: 306 LTLDIF---------AGPPNYPFSDEY 323 >1Q5M-A nrPDB Length = 322 Score = 448 bits (1153), Expect = e-126, Method: Composition-based stats. Identities = 134/326 (41%), Positives = 201/326 (61%), Gaps = 16/326 (4%) Query: 6 VLLHTGQKMPLIGLGTWKS---EPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62 V L G +P++G GT+ + A K A+ G+RHID A Y NE E+G A++ Sbjct: 7 VALSDGHFIPVLGFGTYAPEEVPKSKAMEATKIAIDAGFRHIDSAYFYKNEKEVGLAIRS 66 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + G V RE++F TSKLW T H PE V P+L +L +LQL+Y+DLY++H+P A + G Sbjct: 67 KIADGT-VKREDIFYTSKLWCTFHRPELVRPSLEDSLKNLQLDYVDLYIIHFPTALKPGV 125 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV--RP 180 P + G +D+ TW+A+E GL +++G+SNFN RQ++ IL+ + +P Sbjct: 126 EIIPTDEHGKAIFDTVDICATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKP 185 Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRA-WRDPDEPVLLEEPVVLALAE 239 QVECHPYL Q +L+ C+++G+ + AYS LGS W D PVLLE+P++ ALA+ Sbjct: 186 VCNQVECHPYLNQGKLLEFCKSKGIVLVAYSALGSHREPEWVDQSAPVLLEDPLIGALAK 245 Query: 240 KYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYI 299 K+ ++PA I LR+Q+QR ++ + KS T RI +NI+VF+F E+MK +++LN+N+RY+ Sbjct: 246 KHQQTPALIALRYQLQRGIVVLAKSFTEKRIKENIQVFEFQLPSEDMKVIDSLNRNFRYV 305 Query: 300 VPMLTVDGKRVPRDAGHPLYPFNDPY 325 + GHP YPF+D Y Sbjct: 306 TADFAI---------GHPNYPFSDEY 322 >2FVL-A nrPDB Length = 324 Score = 446 bits (1148), Expect = e-126, Method: Composition-based stats. Identities = 138/326 (42%), Positives = 209/326 (64%), Gaps = 16/326 (4%) Query: 6 VLLHTGQKMPLIGLGTWKSEPGQVKAAV---KYALSVGYRHIDCAAIYGNEPEIGEALKE 62 V L+ G MP++G GT+ AV K A+ G+RHID A +Y NE ++G A++ Sbjct: 9 VELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQVGLAIRS 68 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + G V RE++F TSKLW T P+ V+PAL +L LQL+Y+DLYL+H+P A + G+ Sbjct: 69 KIADGS-VKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPMALKPGE 127 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV--RP 180 P PK+ +G + +D+ TW+ +E GL +++G+SNFN RQ++ IL+ + +P Sbjct: 128 TPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNYRQLEMILNKPGLKYKP 187 Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSD-RAWRDPDEPVLLEEPVVLALAE 239 QVECHPYL Q++L+ C+++ + + A+S LG+ + W DP+ PVLLE+PV+ ALA+ Sbjct: 188 VCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPVLCALAK 247 Query: 240 KYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYI 299 K+ R+PA I LR+Q+QR V+ + KS RI +NI+VF+F + E+MK L+ LN+N+RY+ Sbjct: 248 KHKRTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLNRNYRYV 307 Query: 300 VPMLTVDGKRVPRDAGHPLYPFNDPY 325 V +D HP YPF+D Y Sbjct: 308 VMDFLMD---------HPDYPFSDEY 324 >5JM5-A nrPDB Length = 332 Score = 446 bits (1148), Expect = e-126, Method: Composition-based stats. Identities = 132/327 (40%), Positives = 201/327 (61%), Gaps = 16/327 (4%) Query: 5 CVLLHTGQKMPLIGLGTWKSEP---GQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 61 CV L+ G MP++G GT+ + K A+ G+RHID A +Y NE ++G A++ Sbjct: 7 CVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQVGLAIR 66 Query: 62 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 + G V RE++F TSKLW+T H PE V PAL +L QL+Y+DLYL+H P + + G Sbjct: 67 SKIADGS-VKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPMSLKPG 125 Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV--R 179 + P + +G + +D TW+A+E GL +++G+SNFN RQ++ IL+ + + Sbjct: 126 EELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYK 185 Query: 180 PAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSS-DRAWRDPDEPVLLEEPVVLALA 238 P QVECHPY +++L+ C+++ + + AYS LGS D+ W DP+ PVLLE+PV+ ALA Sbjct: 186 PVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPVLCALA 245 Query: 239 EKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 298 +K+ R+PA I LR+Q+QR V+ + KS RI QN++VF+F + E+MK ++ L++N Y Sbjct: 246 KKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLDRNLHY 305 Query: 299 IVPMLTVDGKRVPRDAGHPLYPFNDPY 325 A HP YP++D Y Sbjct: 306 FN---------SDSFASHPNYPYSDEY 323 >3G1R-A nrPDB Length = 346 Score = 437 bits (1124), Expect = e-123, Method: Composition-based stats. Identities = 142/331 (42%), Positives = 208/331 (62%), Gaps = 17/331 (5%) Query: 2 AASCVLLHTGQKMPLIGLGTWK----SEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIG 57 A+ + L G +P+IGLGT+ + G +VK A+ GYRHID A IY NE E+G Sbjct: 26 ASHRIPLSDGNSIPIIGLGTYSEPKSTPKGACATSVKVAIDTGYRHIDGAYIYQNEHEVG 85 Query: 58 EALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYA 117 EA++E + GK V RE++F KLW T H PE V P L +TL LQL+Y+DLY++ P A Sbjct: 86 EAIREKIAEGK-VRREDIFYCGKLWATNHVPEMVRPTLERTLRVLQLDYVDLYIIEVPMA 144 Query: 118 FERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS 177 F+ GD +P++ +G Y ++ TW+A+EA GLV++LG+SNFN RQ++ IL+ Sbjct: 145 FKPGDEIYPRDENGKWLYHKSNLCATWEAMEACKDAGLVKSLGVSNFNRRQLELILNKPG 204 Query: 178 V--RPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRA-WRDPDEPVLLEEPVV 234 + +P QVECHPY Q +L+ CQ + +TAYSPLG+S W + P LL++ ++ Sbjct: 205 LKHKPVSNQVECHPYFTQPKLLKFCQQHDIVITAYSPLGTSRNPIWVNVSSPPLLKDALL 264 Query: 235 LALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNK 294 +L ++Y ++ AQI+LR+ +QR V+ IPKS RI +N ++FDF+ + EEMK + ALNK Sbjct: 265 NSLGKRYNKTAAQIVLRFNIQRGVVVIPKSFNLERIKENFQIFDFSLTEEEMKDIEALNK 324 Query: 295 NWRYIVPMLTVDGKRVPRDAGHPLYPFNDPY 325 N R++ ++ D HP YPF+D Y Sbjct: 325 NVRFVELLMWRD---------HPEYPFHDEY 346 >2HE8-A nrPDB Length = 323 Score = 435 bits (1119), Expect = e-122, Method: Composition-based stats. Identities = 128/328 (39%), Positives = 199/328 (60%), Gaps = 16/328 (4%) Query: 4 SCVLLHTGQKMPLIGLGT---WKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL 60 CV+L+ G +P++G GT + + K K A+ G+ H D A++Y E +GEA+ Sbjct: 6 HCVILNDGNFIPVLGFGTALPLECPKSKAKELTKIAIDAGFHHFDSASVYNTEDHVGEAI 65 Query: 61 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 120 + + G V RE++F TSK+W T HPE V +L ++L LQ +Y+DLYL+H+P A + Sbjct: 66 RSKIADGT-VRREDIFYTSKVWCTSLHPELVRASLERSLQKLQFDYVDLYLIHYPMALKP 124 Query: 121 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV-- 178 G+ FP + G + +D TW+A+E GL +++G+SNFN RQ++ IL+ + Sbjct: 125 GEENFPVDEHGKLIFDRVDLCATWEAMEKCKDAGLTKSIGVSNFNYRQLEMILNKPGLKY 184 Query: 179 RPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDR-AWRDPDEPVLLEEPVVLAL 237 +P QVECHPYL Q +L+ C+++ + + AY LG+ W D + PVLL+EPV+ ++ Sbjct: 185 KPVCNQVECHPYLNQMKLLDFCKSKDIVLVAYGVLGTQRYGGWVDQNSPVLLDEPVLGSM 244 Query: 238 AEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWR 297 A+KY R+PA I LR+Q+QR ++ + S+ RI +N++VF+F S E+MK L+ LN+N R Sbjct: 245 AKKYNRTPALIALRYQLQRGIVVLNTSLKEERIKENMQVFEFQLSSEDMKVLDGLNRNMR 304 Query: 298 YIVPMLTVDGKRVPRDAGHPLYPFNDPY 325 YI + GHP +PF D Y Sbjct: 305 YIPAAIF---------KGHPNWPFLDEY 323 >1DLA-A nrPDB Length = 314 Score = 434 bits (1117), Expect = e-122, Method: Composition-based stats. Identities = 163/324 (50%), Positives = 227/324 (70%), Gaps = 12/324 (3%) Query: 4 SCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKED 63 S ++L+TG KMP++GLGTWKS PG+V AVK A+ +GYRHIDCA +Y NE E+G L+E Sbjct: 1 SHLVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLGLQEK 60 Query: 64 VGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDN 123 + G+ V RE+LF+ SKLW T H V+ A + TL DL+L+YLDLYL+HWP F+ G + Sbjct: 61 LQ-GQVVKREDLFIVSKLWCTDHEKNLVKGACQTTLRDLKLDYLDLYLIHWPTGFKPGKD 119 Query: 124 PFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR--PA 181 PFP + DG + D + + ETW+A+E LV +GLV+A+G+SNFN Q++ IL+ ++ PA Sbjct: 120 PFPLDGDGNVVPDESDFVETWEAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPA 179 Query: 182 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKY 241 V Q+E HPYL Q +LI +C+++G+ VTAYSPLGS DR W P++P LLE+P + A+A KY Sbjct: 180 VNQIEVHPYLTQEKLIEYCKSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKY 239 Query: 242 GRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVP 301 ++ AQ+L+R+ +QR +I IPKS+TP RI +N +VFDF SPE+M L + N+NWR Sbjct: 240 NKTTAQVLIRFPMQRNLIVIPKSVTPERIAENFQVFDFELSPEDMNTLLSYNRNWRVCAL 299 Query: 302 MLTVDGKRVPRDAGHPLYPFNDPY 325 M A H YPF++ Y Sbjct: 300 MSC---------ASHKDYPFHEEY 314 >3RX4-A nrPDB Length = 336 Score = 434 bits (1116), Expect = e-122, Method: Composition-based stats. Identities = 160/325 (49%), Positives = 223/325 (68%), Gaps = 12/325 (3%) Query: 3 ASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62 AS +LL+ G KMP++GLGTWKS PGQV AVK A+ VGYRHIDCA +Y NE E+G A++E Sbjct: 22 ASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQE 81 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + + V REELF+ SKLW T H V+ A +KTL+DL+L+YLDLYL+HWP F+ G Sbjct: 82 KLRE-QVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK 140 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR--P 180 FP + G + T+ +TW A+E LV +GLV+A+G+SNFN Q++ IL+ ++ P Sbjct: 141 EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP 200 Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240 AV Q+ECHPYL Q +LI +CQ++G+ VTAYSPLGS DR W P++P LLE+P + A+A K Sbjct: 201 AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK 260 Query: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 300 + ++ AQ+L+R+ +QR ++ IPKS+TP RI +N KVFDF S ++M L + N+NWR Sbjct: 261 HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA 320 Query: 301 PMLTVDGKRVPRDAGHPLYPFNDPY 325 + H YPF++ + Sbjct: 321 LLSC---------TSHKDYPFHEEF 336 >1AFS-A nrPDB Length = 323 Score = 431 bits (1109), Expect = e-121, Method: Composition-based stats. Identities = 127/325 (39%), Positives = 201/325 (61%), Gaps = 16/325 (4%) Query: 6 VLLHTGQKMPLIGLGTW---KSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62 V L+ G +P++G GT K +V A K A+ G+RH D A +Y E E+G+A++ Sbjct: 8 VALNDGNFIPVLGFGTTVPEKVAKDEVIKATKIAIDNGFRHFDSAYLYEVEEEVGQAIRS 67 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + G V RE++F TSKLW+T H PE V L KTL QL+Y+DLY++H+P A + GD Sbjct: 68 KIEDGT-VKREDIFYTSKLWSTFHRPELVRTCLEKTLKSTQLDYVDLYIIHFPMALQPGD 126 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV--RP 180 FP++ G + +++ +TW+A+E GL +++G+SNFN RQ++ IL+ + +P Sbjct: 127 IFFPRDEHGKLLFETVDICDTWEAMEKCKDAGLAKSIGVSNFNCRQLERILNKPGLKYKP 186 Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSS-DRAWRDPDEPVLLEEPVVLALAE 239 QVECH YL Q++++ +C+++ + + +Y LGSS D+ W D PVLL++PV+ A+A+ Sbjct: 187 VCNQVECHLYLNQSKMLDYCKSKDIILVSYCTLGSSRDKTWVDQKSPVLLDDPVLCAIAK 246 Query: 240 KYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYI 299 KY ++PA + LR+Q+QR V+ + +S RI + +VF+F + E+MK L+ LN+N+RY Sbjct: 247 KYKQTPALVALRYQLQRGVVPLIRSFNAKRIKELTQVFEFQLASEDMKALDGLNRNFRYN 306 Query: 300 VPMLTVDGKRVPRDAGHPLYPFNDP 324 D HP +PF D Sbjct: 307 NAKYFDD---------HPNHPFTDE 322 >5UXF-A nrPDB Length = 342 Score = 430 bits (1105), Expect = e-121, Method: Composition-based stats. Identities = 138/328 (42%), Positives = 201/328 (61%), Gaps = 16/328 (4%) Query: 4 SCVLLHTGQKMPLIGLGTWKS---EPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL 60 CV L+ G +P +G GT+K + A AL VGYRH+D A Y E EIG+A+ Sbjct: 25 HCVKLNDGHLIPALGFGTYKPKEVPKSKSLEAACLALDVGYRHVDTAYAYQVEEEIGQAI 84 Query: 61 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 120 + + G V RE+LFVT+KLW T PE V+PAL K+L LQL+Y+DLY+MH+P + Sbjct: 85 QSAIAAG-VVKREDLFVTTKLWCTCFRPELVKPALEKSLKKLQLDYVDLYIMHYPVPMKS 143 Query: 121 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV-- 178 GDN FP N G D+ + +TW+ LE GLV+++G+SNFN RQ++ IL+ + Sbjct: 144 GDNDFPVNEQGKSLLDTVDFCDTWERLEECKDAGLVKSIGVSNFNHRQLERILNKPGLKY 203 Query: 179 RPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSD-RAWRDPDEPVLLEEPVVLAL 237 +P QVECH YL Q +L+ +C+++ + + AY LG+ + W D + PVLL +PV+ + Sbjct: 204 KPVCNQVECHLYLNQRKLLDYCESKDIVLVAYGALGTQRYKEWVDQNSPVLLNDPVLCDV 263 Query: 238 AEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWR 297 A+K RSPA I LR+ +QR ++ + +S + + +N++VF F SPE+MK L+ LNKN+R Sbjct: 264 AKKNKRSPALIALRYLIQRGIVPLAQSFKENEMRENLQVFGFQLSPEDMKTLDGLNKNFR 323 Query: 298 YIVPMLTVDGKRVPRDAGHPLYPFNDPY 325 Y+ VD HP YPF + Y Sbjct: 324 YLPAEFLVD---------HPEYPFVEEY 342 >1C9W-A nrPDB Length = 315 Score = 422 bits (1085), Expect = e-118, Method: Composition-based stats. Identities = 153/316 (48%), Positives = 216/316 (68%), Gaps = 3/316 (0%) Query: 3 ASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62 ++ V L T KMP++GLGTW+S PGQVK AVK A+ GYRHIDCA Y NE E+GEA++E Sbjct: 1 STFVELSTKAKMPIVGLGTWQSPPGQVKEAVKVAIDAGYRHIDCAYAYYNEHEVGEAIQE 60 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + KAV RE+LF+ SKLW T + ++ A +KTL DL+L+YLDLYL+HWP + G Sbjct: 61 KIKE-KAVRREDLFIVSKLWPTCFERKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGK 119 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR--P 180 FPK+ G + + + W+ +E LV +GLV+ALG+SNFN QI+ IL+ ++ P Sbjct: 120 ELFPKDDQGNVLTSKITFLDAWEVMEELVDEGLVKALGVSNFNHFQIERILNKPGLKHKP 179 Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240 QVECHPYL Q +LI +C ++G+ VTAYSPLGS +R W P++P LLE+P + +A K Sbjct: 180 VTNQVECHPYLTQEKLIEYCHSKGITVTAYSPLGSPNRPWAKPEDPSLLEDPKIKEIAAK 239 Query: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 300 + ++ AQ+L+R+ +QR V+ IPKS+TP+RI +N +VFDF S +EM + N+NWR + Sbjct: 240 HKKTSAQVLIRFHIQRNVVVIPKSVTPARIHENFQVFDFQLSDQEMATILGFNRNWRACL 299 Query: 301 PMLTVDGKRVPRDAGH 316 TV+ + P DA + Sbjct: 300 LPETVNMEEYPYDAEY 315 >1FRB-A nrPDB Length = 315 Score = 419 bits (1077), Expect = e-118, Method: Composition-based stats. Identities = 159/316 (50%), Positives = 217/316 (68%), Gaps = 3/316 (0%) Query: 3 ASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62 A+ V L T KMP++GLGTWKS P QVK AVK A+ GYRHIDCA Y NE E+GEA++E Sbjct: 1 ATFVELSTKAKMPIVGLGTWKSPPNQVKEAVKAAIDAGYRHIDCAYAYCNENEVGEAIQE 60 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + KAV RE+LF+ SKLW T + ++ A +KTL DL+L+YLDLYL+HWP + G Sbjct: 61 KIKE-KAVQREDLFIVSKLWPTCFEKKLLKEAFQKTLTDLKLDYLDLYLIHWPQGLQPGK 119 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR--P 180 FPK+ G I T + E W+ +E LV +GLV+ALG+SNFN QI+ +L+ ++ P Sbjct: 120 ELFPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKP 179 Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240 QVECHPYL Q +LI +C ++G+ VTAYSPLGS DR P++P LLE+P + +A K Sbjct: 180 VTNQVECHPYLTQEKLIQYCHSKGISVTAYSPLGSPDRPSAKPEDPSLLEDPKIKEIAAK 239 Query: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 300 + ++ AQ+L+R+ +QR V+ IPKS+TPSRI +NI+VFDF S EEM + + N+NWR + Sbjct: 240 HEKTSAQVLIRFHIQRNVVVIPKSVTPSRIQENIQVFDFQLSDEEMATILSFNRNWRACL 299 Query: 301 PMLTVDGKRVPRDAGH 316 TV+ + P DA + Sbjct: 300 LPETVNMEEYPYDAEY 315 >4HBK-A nrPDB Length = 344 Score = 417 bits (1073), Expect = e-117, Method: Composition-based stats. Identities = 147/320 (45%), Positives = 213/320 (66%), Gaps = 13/320 (4%) Query: 6 VLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVG 65 + ++ G+ +P+IGLGTW S PG+V AAVK AL +GYRH+DCA +Y NE EIGEAL+ + Sbjct: 38 LKMNNGRSIPVIGLGTWNSPPGEVGAAVKKALEIGYRHLDCAYVYRNEAEIGEALENALN 97 Query: 66 PGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPF 125 + + RE++F+TSKLWNT PE V A +TL +L+L YLDLYL+HWP + G + F Sbjct: 98 SLR-LKREDIFITSKLWNTFFRPEHVRKACEETLKNLRLNYLDLYLIHWPVPLKHGGDLF 156 Query: 126 PKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQV 185 P +++G +C D+ +++TWK +E LV +GLV+++GLSNFN RQI +IL ++PA LQ+ Sbjct: 157 PTDSNGQLCLDNVPHEDTWKEMEKLVDEGLVKSIGLSNFNKRQIQNILEHCRIKPANLQI 216 Query: 186 ECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSP 245 E H +L+ + Q+ GL VTAY+PLGS P + LL +P VL +A ++ ++P Sbjct: 217 EIHANFPNIKLVEYAQSVGLTVTAYAPLGSPA---HSPGKVNLLTKPCVLEIAHRHKKTP 273 Query: 246 AQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTV 305 AQ+LLR+ +QRK+I +PKS+T RI +N +VFDF S EEM +LN + N R + Sbjct: 274 AQVLLRYLLQRKLIVVPKSVTFKRIEENFQVFDFQLSNEEMHELNTESLNERQFTLL--- 330 Query: 306 DGKRVPRDAGHPLYPFNDPY 325 + +GH YPF + Y Sbjct: 331 ------QMSGHQEYPFKEEY 344 >3O3R-A nrPDB Length = 316 Score = 415 bits (1067), Expect = e-116, Method: Composition-based stats. Identities = 153/325 (47%), Positives = 217/325 (66%), Gaps = 12/325 (3%) Query: 3 ASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62 + V L T KMPL+GLGTWKS PGQVK AVK A+ GYRH DCA +Y NE E+GEA++E Sbjct: 2 TTFVKLRTKAKMPLVGLGTWKSPPGQVKEAVKAAIDAGYRHFDCAYVYQNESEVGEAIQE 61 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 + KAV RE+LF+ SKLW+T ++ A +KTL+DL+L+YLDLYL+HWP + G Sbjct: 62 KIKE-KAVRREDLFIVSKLWSTFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGLQAGK 120 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR--P 180 PK++ G + + + + W+ +E LV +GLV+ALG+SNFN QI+ +L+ ++ P Sbjct: 121 EFLPKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKP 180 Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240 QVECHPYL Q +LI +C ++G+ V AYSPLGS DR + P++PV+LE P + +A K Sbjct: 181 VTNQVECHPYLTQEKLIQYCHSKGIAVIAYSPLGSPDRPYAKPEDPVVLEIPKIKEIAAK 240 Query: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 300 + ++ AQ+L+R+ VQR V IPKS+T S I +NI+VFDF S E+M + +LN+NWR Sbjct: 241 HKKTIAQVLIRFHVQRNVAVIPKSVTLSHIKENIQVFDFQLSEEDMAAILSLNRNWRACG 300 Query: 301 PMLTVDGKRVPRDAGHPLYPFNDPY 325 +T D + +PF++ Y Sbjct: 301 LFVTSDEE---------DFPFHEEY 316 >5ZCM-A nrPDB Length = 341 Score = 395 bits (1016), Expect = e-110, Method: Composition-based stats. Identities = 128/320 (40%), Positives = 192/320 (60%), Gaps = 11/320 (3%) Query: 5 CVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDV 64 + L++G +MPL+G G WK + V A+ VGYR D A YGN EIGE + + Sbjct: 23 SIKLNSGYEMPLVGFGCWKVDNATCADTVYNAIKVGYRLFDAAMDYGNCKEIGEGINRAL 82 Query: 65 GPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFE----- 119 G V R+ELF+TSKLWN+ H P++VE AL+K L+D++L+Y+DL+L+H+P AF+ Sbjct: 83 DEGL-VARDELFITSKLWNSYHDPKNVELALKKVLSDMKLDYIDLFLIHFPIAFKFVPFE 141 Query: 120 -RGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV 178 + F Y+ ETWKA+E L G +++G+SNF++ I D+L A + Sbjct: 142 EKYPPAFYCGDGDNFHYEDVPLLETWKAMEKLTKGGKAKSIGISNFSAALIYDLLRGAEI 201 Query: 179 RPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSD----RAWRDPDEPVLLEEPVV 234 +PAVLQ+E HPYL Q LI + Q++G+ +TAYS G + + D P L E + Sbjct: 202 KPAVLQIEHHPYLQQPRLIEYVQSQGIAITAYSSFGPQSFLELKHSKALDTPTLFEHKTI 261 Query: 235 LALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNK 294 ++A+KY ++PAQ+LLRW QR + IPKS P R+LQN++V DF S E+ +++ L++ Sbjct: 262 TSIADKYKKTPAQVLLRWASQRDIAIIPKSNNPDRLLQNLEVNDFNLSKEDFDEISKLDQ 321 Query: 295 NWRYIVPMLTVDGKRVPRDA 314 + R+ P R+P A Sbjct: 322 DLRFNNPWDWDTKNRIPIFA 341 >3H7U-A nrPDB Length = 335 Score = 392 bits (1008), Expect = e-110, Method: Composition-based stats. Identities = 134/318 (42%), Positives = 187/318 (58%), Gaps = 10/318 (3%) Query: 2 AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 61 A + L+TG K P +GLGTW++ PG V AV A+ +GYRHIDCA IYGNE EIG LK Sbjct: 24 AITFFKLNTGAKFPSVGLGTWQASPGLVGDAVAAAVKIGYRHIDCAQIYGNEKEIGAVLK 83 Query: 62 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 + + V RE+LF+TSKLW T H P+DV AL +TL DLQLEY+DLYL+HWP ++G Sbjct: 84 KLFED-RVVKREDLFITSKLWCTDHDPQDVPEALNRTLKDLQLEYVDLYLIHWPARIKKG 142 Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPA 181 TWKA+EAL G +A+G+SNF+++++ D+L +A V PA Sbjct: 143 SVGIKPEN-----LLPVDIPSTWKAMEALYDSGKARAIGVSNFSTKKLADLLELARVPPA 197 Query: 182 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKY 241 V QVECHP Q +L C+++G+ ++AYSPLGS W D +L+ P++ +AEK Sbjct: 198 VNQVECHPSWRQTKLQEFCKSKGVHLSAYSPLGSPGTTWLKSD---VLKNPILNMVAEKL 254 Query: 242 GRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVP 301 G+SPAQ+ LRW +Q +PKS RI +N VFD++ + + + R + Sbjct: 255 GKSPAQVALRWGLQMGHSVLPKSTNEGRIKENFNVFDWSIPDYMFAKFAEIEQ-ARLVTG 313 Query: 302 MLTVDGKRVPRDAGHPLY 319 V P + L+ Sbjct: 314 SFLVHETLSPYKSIEELW 331 >5Z6T-A nrPDB Length = 343 Score = 392 bits (1007), Expect = e-109, Method: Composition-based stats. Identities = 122/312 (39%), Positives = 175/312 (56%), Gaps = 11/312 (3%) Query: 4 SCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKED 63 + L++G MP +G G WK + + A+ GYR D A Y NE +G +K+ Sbjct: 27 PSIKLNSGYDMPAVGFGCWKVDVDTCSEQIYRAIKTGYRLFDGAEDYANEKLVGAGVKKA 86 Query: 64 VGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFE---- 119 + G V RE+LF+TSKLWN HHP++VE AL +TL+DLQ++Y+DL+L+H+P F+ Sbjct: 87 IDEG-IVKREDLFLTSKLWNNYHHPDNVEKALNRTLSDLQVDYVDLFLIHFPVTFKFVPL 145 Query: 120 --RGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS 177 + F Y+ ETWKALE LV G ++++G+SNF + D+L A+ Sbjct: 146 EEKYPPGFYCGKGDNFDYEDVPILETWKALEKLVKAGKIRSIGVSNFPGALLLDLLRGAT 205 Query: 178 VRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSD----RAWRDPDEPVLLEEPV 233 ++P+VLQVE HPYL Q LI Q+RG+ VTAYS G R + L E Sbjct: 206 IKPSVLQVEHHPYLQQPRLIEFAQSRGIAVTAYSSFGPQSFVELNQGRALNTSPLFENET 265 Query: 234 VLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALN 293 + A+A K+G+SPAQ+LLRW QR + IPKS T R+L+N V F ++ + L+ Sbjct: 266 IKAIAAKHGKSPAQVLLRWSSQRGIAIIPKSNTVPRLLENKDVNSFDLDEQDFADIAKLD 325 Query: 294 KNWRYIVPMLTV 305 N R+ P Sbjct: 326 INLRFNDPWDWD 337 >5JH1-A nrPDB Length = 309 Score = 391 bits (1004), Expect = e-109, Method: Composition-based stats. Identities = 134/292 (45%), Positives = 195/292 (66%), Gaps = 10/292 (3%) Query: 3 ASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62 A +L+TG K+P +GLG+W+S+PG V AV A+ GYRHIDCA +YGNE EIG ALK+ Sbjct: 1 ARHFVLNTGAKIPSVGLGSWQSDPGVVGNAVYAAVKAGYRHIDCARVYGNEKEIGLALKK 60 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 G V RE++F+TSKLWN H PEDV AL +L DLQLEYLDLYL+HWP+ ++G Sbjct: 61 LFEEG-VVKREDMFITSKLWNDHHAPEDVPEALNDSLNDLQLEYLDLYLIHWPFRVKKGT 119 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAV 182 N P+N + + + TW A+E L G +A+G+SNF+S+++ D+L+VA V PAV Sbjct: 120 NTSPEN------FVTPDFPATWGAMEKLYDAGKARAIGVSNFSSKKLGDLLAVARVPPAV 173 Query: 183 LQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYG 242 QVECHP Q +L + CQ+ G+ +TAYSPLGS W + + +L+EP+++++AEK G Sbjct: 174 DQVECHPGWQQTKLHSFCQSTGVHLTAYSPLGSPGTTWMNGN---VLKEPIIISIAEKLG 230 Query: 243 RSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNK 294 ++ AQ+ LRW +Q +PKS RI QN+ V+D++ + + + + + + Sbjct: 231 KTSAQVALRWNIQMGHSVLPKSTNEERIKQNLDVYDWSIPDDLLAKFSEIKQ 282 >1K8C-A nrPDB Length = 322 Score = 386 bits (992), Expect = e-108, Method: Composition-based stats. Identities = 124/315 (39%), Positives = 177/315 (56%), Gaps = 11/315 (3%) Query: 2 AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 61 + + L +G MP IG G WK V A+ GYR D A YGNE E+G+ +K Sbjct: 4 SIPDIKLSSGHLMPSIGFGCWKLANATAGEQVYQAIKAGYRLFDGAEDYGNEKEVGDGVK 63 Query: 62 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFE-- 119 + G V REE+F+TSKLWN H P++VE AL KTLADL+++Y+DL+L+H+P AF+ Sbjct: 64 RAIDEGL-VKREEIFLTSKLWNNYHDPKNVETALNKTLADLKVDYVDLFLIHFPIAFKFV 122 Query: 120 ----RGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSV 175 + F Y+ ETWKALE LVA G ++++G+SNF + D+L Sbjct: 123 PIEEKYPPGFYCGDGNNFVYEDVPILETWKALEKLVAAGKIKSIGVSNFPGALLLDLLRG 182 Query: 176 ASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSD----RAWRDPDEPVLLEE 231 A+++PAVLQVE HPYL Q +LI Q G+ +TAYS G R + P L Sbjct: 183 ATIKPAVLQVEHHPYLQQPKLIEFAQKAGVTITAYSSFGPQSFVEMNQGRALNTPTLFAH 242 Query: 232 PVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNA 291 + A+A KY ++PA++LLRW QR + IPKS P R++QN F + E+ +++ Sbjct: 243 DTIKAIAAKYNKTPAEVLLRWAAQRGIAVIPKSNLPERLVQNRSFNTFDLTKEDFEEIAK 302 Query: 292 LNKNWRYIVPMLTVD 306 L+ R+ P + Sbjct: 303 LDIGLRFNDPWDWDN 317 >3WCZ-A nrPDB Length = 308 Score = 377 bits (967), Expect = e-105, Method: Composition-based stats. Identities = 128/326 (39%), Positives = 189/326 (57%), Gaps = 27/326 (8%) Query: 1 MAASCVLLHTGQKMPLIGLGTWK------SEPGQVKAAVKYALSVGYRHIDCAAIYGNEP 54 + A C+ L+ G +P++ LGT + +V+ AV +A+ GYRHID AA+Y +E Sbjct: 3 VQAPCIQLNDGNTIPIVALGTGRGTAKESDSIDEVRQAVYWAIEAGYRHIDTAAVYQDEE 62 Query: 55 EIGEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHW 114 ++G+ + E + G V REELFVT+KLWN KH + V PAL+++L L L+Y+DLYL+H+ Sbjct: 63 QVGQGIAEAIANGL-VTREELFVTTKLWNDKHARDQVVPALQESLKKLGLDYIDLYLIHF 121 Query: 115 PYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILS 174 P A + D+P D+ Y ETW+ ++ GL +++G+SNFN+ QI ++S Sbjct: 122 PIATKPDDSP-----------DNIDYLETWQGMQDARQLGLARSIGVSNFNATQITRLVS 170 Query: 175 VASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVV 234 + +RP + Q+E +P Q L+AHCQ+ G+ V AYSP G + P ++P + Sbjct: 171 NSYIRPVINQIEVNPTNTQEPLVAHCQSLGIAVMAYSPFGFVVSRGQTGAPPPRSDDPTL 230 Query: 235 LALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNK 294 ALA KY +S QILLR+ + R +I IPKS RI QNI +FDF + EE+ +N NK Sbjct: 231 TALANKYRKSVGQILLRYLIDRGLIPIPKSTNKQRIAQNIDLFDFQLTFEEVAAINQFNK 290 Query: 295 NWRYIVPMLTVDGKRVPRDAGHPLYP 320 N R I D +P YP Sbjct: 291 NHRVIDISDWKD---------YPNYP 307 >4GIE-A nrPDB Length = 290 Score = 364 bits (935), Expect = e-101, Method: Composition-based stats. Identities = 110/296 (37%), Positives = 170/296 (57%), Gaps = 33/296 (11%) Query: 4 SCVLLHTGQKMPLIGLGTWKSEPG-QVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62 +CV LH +MP +GLG W+++ G + AV++A+ GYRHID A IY NE +G+ ++E Sbjct: 14 NCVTLHNSVRMPQLGLGVWRAQDGAETANAVRWAIEAGYRHIDTAYIYSNERGVGQGIRE 73 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 VPREE++VT+K+WN+ E A ++ L LEY+DLYL+HWP + Sbjct: 74 -----SGVPREEVWVTTKVWNSDQGYEKTLAAFERSRELLGLEYIDLYLIHWPGKKK--- 125 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAV 182 + +TWKALE L + V+A+G+SNF + ++ +RP V Sbjct: 126 -----------------FVDTWKALEKLYEEKKVRAIGVSNFEPHHLTELFKSCKIRPMV 168 Query: 183 LQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYG 242 QVE HP Q L C+ + +TA+SPLGS +E +L+ V+ +A+K+ Sbjct: 169 NQVELHPLFQQRTLREFCKQHNIAITAWSPLGSG-------EEAGILKNHVLGEIAKKHN 221 Query: 243 RSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 298 +SPAQ+++RW +Q ++ IPKS RI +N V+DF + EEM+Q++ LN++ R Sbjct: 222 KSPAQVVIRWDIQHGIVTIPKSTNKGRIQENFNVWDFKLTEEEMRQIDELNEDKRI 277 >3H7R-A nrPDB Length = 331 Score = 364 bits (934), Expect = e-101, Method: Composition-based stats. Identities = 127/286 (44%), Positives = 183/286 (63%), Gaps = 15/286 (5%) Query: 1 MAAS--CVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGE 58 MAA L+TG K+P +GLGT+ V A++ A+ +GYRHIDCA+IYGNE EIG Sbjct: 21 MAAPIRFFELNTGAKLPCVGLGTY----AMVATAIEQAIKIGYRHIDCASIYGNEKEIGG 76 Query: 59 ALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAF 118 LK+ +G G V REELF+TSKLW+ H PEDV AL KTL DLQ++Y+DLYL+HWP + Sbjct: 77 VLKKLIGDG-FVKREELFITSKLWSNDHLPEDVPKALEKTLQDLQIDYVDLYLIHWPASL 135 Query: 119 ERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV 178 ++ ++ P TWKA+EAL G +A+G+SNF+S+++ D+L+VA V Sbjct: 136 KK-ESLMPTPE----MLTKPDITSTWKAMEALYDSGKARAIGVSNFSSKKLTDLLNVARV 190 Query: 179 RPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALA 238 PAV QVECHP Q L C+++G+ ++ YSPLGS + +L+ P+V +A Sbjct: 191 TPAVNQVECHPVWQQQGLHELCKSKGVHLSGYSPLGSQSKGEVRL---KVLQNPIVTEVA 247 Query: 239 EKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPE 284 EK G++ AQ+ LRW +Q +PKS + +R+ +N+ VFD++ + Sbjct: 248 EKLGKTTAQVALRWGLQTGHSVLPKSSSGARLKENLDVFDWSIPED 293 >1VBJ-A nrPDB Length = 281 Score = 361 bits (926), Expect = e-100, Method: Composition-based stats. Identities = 114/306 (37%), Positives = 169/306 (55%), Gaps = 37/306 (12%) Query: 3 ASCVLLHTGQKMPLIGLGTWKSEPG-QVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 61 + L G MP++G G WK + G + + A +A+ GYRHID AAIY NE G A+ Sbjct: 9 TQSLKLSNGVMMPVLGFGMWKLQDGNEAETATMWAIKSGYRHIDTAAIYKNEESAGRAIA 68 Query: 62 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 VPREELFVT+KLWN+ E A K++ L LEY+DLYL+HWP + Sbjct: 69 S-----CGVPREELFVTTKLWNSDQGYESTLSAFEKSIKKLGLEYVDLYLIHWPGKDK-- 121 Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPA 181 + +TWKA E L A V+A+G+SNF+ I+++L V P Sbjct: 122 ------------------FIDTWKAFEKLYADKKVRAIGVSNFHEHHIEELLKHCKVAPM 163 Query: 182 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKY 241 V Q+E HP L Q L +C+++ + VTA+SPLG L+E+ + A+ KY Sbjct: 164 VNQIELHPLLNQKALCEYCKSKNIAVTAWSPLGQGH----------LVEDARLKAIGGKY 213 Query: 242 GRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY-IV 300 G++ AQ++LRW++Q VI IPKS +RI +N +FDF + E+++ ++ +N RY Sbjct: 214 GKTAAQVMLRWEIQAGVITIPKSGNEARIKENGNIFDFELTAEDIQVIDGMNAGHRYGPD 273 Query: 301 PMLTVD 306 P + ++ Sbjct: 274 PEVFMN 279 >3KRB-A nrPDB Length = 334 Score = 361 bits (926), Expect = e-100, Method: Composition-based stats. Identities = 122/302 (40%), Positives = 179/302 (59%), Gaps = 12/302 (3%) Query: 15 PLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGK-AVPRE 73 P +G GTW++ P V+ AV+ AL GYRHIDCA +Y NE IG A + + RE Sbjct: 26 PRLGFGTWQAPPEAVQTAVETALMTGYRHIDCAYVYQNEEAIGRAFGKIFKDASSGIKRE 85 Query: 74 ELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD--NPFPKNADG 131 ++++TSKLWN H PE V +KT++DLQ++YLDL+L+HWP AF R D + FPK+A+G Sbjct: 86 DVWITSKLWNYNHRPELVREQCKKTMSDLQVDYLDLFLVHWPLAFVRNDVGDLFPKDAEG 145 Query: 132 TICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYL 191 + +TW+A+E LV +GLV+ +G+SN+ + D+L+ A ++P V Q+E HP+ Sbjct: 146 RAMLEKVPLADTWRAMEQLVEEGLVKHIGVSNYTVPLLADLLNYAKIKPLVNQIEIHPWH 205 Query: 192 AQNELIAHCQARGLEVTAYSPLGSSDRAWRDP---DEPVLLEEPVVLALAEKYGRSPAQI 248 + + C G+ VTAYSP+G S RDP + V+LE + A+A+ G SP + Sbjct: 206 PNDATVKFCLDNGIGVTAYSPMGGSYADPRDPSGTQKNVILECKTLKAIADAKGTSPHCV 265 Query: 249 LLRWQVQR----KVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNA--LNKNWRYIVPM 302 L W V++ IPKS TP+RI N K + S ++M +N LNK R+ P Sbjct: 266 ALAWHVKKWNTSMYSVIPKSQTPARIEANFKCTEVQLSDDDMDAINNIHLNKRIRFCDPA 325 Query: 303 LT 304 + Sbjct: 326 IF 327 >4F40-A nrPDB Length = 288 Score = 360 bits (925), Expect = e-100, Method: Composition-based stats. Identities = 119/296 (40%), Positives = 173/296 (58%), Gaps = 28/296 (9%) Query: 4 SCVLLHTGQKMPLIGLGTWKSEPGQVKA-AVKYALSVGYRHIDCAAIYGNEPEIGEALKE 62 + V L G KMP GLG W+S G+V AVK+AL GYRHID AAIY NE +G L+ Sbjct: 11 AMVTLSNGVKMPQFGLGVWQSPAGEVTENAVKWALCAGYRHIDTAAIYKNEESVGAGLR- 69 Query: 63 DVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGD 122 VPRE++F+T+KLWNT+ E A ++ L ++Y+DLYL+HWP RG Sbjct: 70 ----ASGVPREDVFITTKLWNTEQGYESTLAAFEESRQKLGVDYIDLYLIHWP----RGK 121 Query: 123 NPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAV 182 + K Y ++W+A E L + V+A+G+SNF+ ++D+L++ +V P V Sbjct: 122 DILSKEGK--------KYLDSWRAFEQLYKEKKVRAIGVSNFHIHHLEDVLAMCTVTPMV 173 Query: 183 LQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYG 242 QVE HP Q +L A C A+ ++V A+SPLG LL P++ A+ KY Sbjct: 174 NQVELHPLNNQADLRAFCDAKQIKVEAWSPLGQG----------KLLSNPILSAIGAKYN 223 Query: 243 RSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 298 ++ AQ++LRW +Q+ +I IPKS+ RI +N +FDF E++ ++ALN N RY Sbjct: 224 KTAAQVILRWNIQKNLITIPKSVHRERIEENADIFDFELGAEDVMSIDALNTNSRY 279 >2BGQ-A nrPDB Length = 344 Score = 356 bits (915), Expect = 5e-99, Method: Composition-based stats. Identities = 115/316 (36%), Positives = 176/316 (55%), Gaps = 15/316 (4%) Query: 5 CVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDV 64 +L +G MP +GLGTW++ + GYRH+D AA YG E E+G+ LK + Sbjct: 39 HFVLKSGHAMPAVGLGTWRAGSDTAHSVRTAITEAGYRHVDTAAEYGVEKEVGKGLKAAM 98 Query: 65 GPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNP 124 G + R++LFVTSK+W T PE V PAL TL DLQL+Y+DLY +HWP+ + G + Sbjct: 99 EAG--IDRKDLFVTSKIWCTNLAPERVRPALENTLKDLQLDYIDLYHIHWPFRLKDGAH- 155 Query: 125 FPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQ 184 P A + +D + WK +E LV GLV+ +G+ N+ +++ +L A + PAV Q Sbjct: 156 MPPEAGEVLEFD---MEGVWKEMENLVKDGLVKDIGVCNYTVTKLNRLLRSAKIPPAVCQ 212 Query: 185 VECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRS 244 +E HP +++ C+ G+ +TAYSPLGSS++ L +PVV +A K ++ Sbjct: 213 MEMHPGWKNDKIFEACKKHGIHITAYSPLGSSEK--------NLAHDPVVEKVANKLNKT 264 Query: 245 PAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV-PML 303 P Q+L++W +QR IPKS RI +NI+VF + E+ K L ++ R + L Sbjct: 265 PGQVLIKWALQRGTSVIPKSSKDERIKENIQVFGWEIPEEDFKVLCSIKDEKRVLTGEEL 324 Query: 304 TVDGKRVPRDAGHPLY 319 V+ P + ++ Sbjct: 325 FVNKTHGPYRSARDVW 340 >1QWK-A nrPDB Length = 317 Score = 349 bits (895), Expect = 1e-96, Method: Composition-based stats. Identities = 121/332 (36%), Positives = 179/332 (53%), Gaps = 29/332 (8%) Query: 2 AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 61 A + + L G +MP+IGLGTW+S P +V AVK A+ GYR ID A++Y NE IG A+K Sbjct: 4 ATASIKLSNGVEMPVIGLGTWQSSPAEVITAVKTAVKAGYRLIDTASVYQNEEAIGTAIK 63 Query: 62 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 E + G V REELF+T+K W + P +E LR++L LQLEY+DLYL H P AF Sbjct: 64 ELLEEG-VVKREELFITTKAWTHELAPGKLEGGLRESLKKLQLEYVDLYLAHMPAAFN-- 120 Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPA 181 D + ++ ++ W+ +A+ GL +A+G+SN+N+ QI L++ Sbjct: 121 --------DDMSEHIASPVEDVWRQFDAVYKAGLAKAVGVSNWNNDQISRALALGLTPVH 172 Query: 182 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDE---------PVLLEEP 232 QVE H Y Q++ + C+ + VT+Y+ LGS R P L++ Sbjct: 173 NSQVELHLYFPQHDHVDFCKKHNISVTSYATLGSPGRVNFTLPTGQKLDWAPAPSDLQDQ 232 Query: 233 VVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNAL 292 VLALAEK ++PAQ+LLR+ + R +PKSI +RI +N +VFDF+ + E++ +L Sbjct: 233 NVLALAEKTHKTPAQVLLRYALDRGCAILPKSIQENRIKENFEVFDFSLTEEDIAKLEES 292 Query: 293 NKNWRYIVPMLTVDGKRVPRDAGHPLYPFNDP 324 + R + GHP F Sbjct: 293 KNSQRLFLQDF---------MTGHPEDAFAAE 315 >1VP5-A nrPDB Length = 298 Score = 348 bits (893), Expect = 2e-96, Method: Composition-based stats. Identities = 100/295 (33%), Positives = 161/295 (54%), Gaps = 30/295 (10%) Query: 1 MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL 60 M V L+ G +MP++G G ++ P + + V A+ VGYR ID AA Y NE +G A+ Sbjct: 13 MQVPKVTLNNGVEMPILGYGVFQIPPEKTEECVYEAIKVGYRLIDTAASYMNEEGVGRAI 72 Query: 61 KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER 120 K + G V REELFVT+KLW + E + A K+L LQLEY+DLYL+H P+ Sbjct: 73 KRAIDEG-IVRREELFVTTKLWVSDVGYESTKKAFEKSLKKLQLEYIDLYLIHQPFG--- 128 Query: 121 GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP 180 WKA+E + GLV+A+G+SNF ++ D++ + P Sbjct: 129 ------------------DVHCAWKAMEEMYKDGLVRAIGVSNFYPDRLMDLMVHHEIVP 170 Query: 181 AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK 240 AV Q+E HP+ + E I + ++ A+ P + + + V+ ++AEK Sbjct: 171 AVNQIEIHPFYQRQEEIEFMRNYNIQPEAWGPFAEGRK--------NIFQNGVLRSIAEK 222 Query: 241 YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKN 295 YG++ AQ++LRW Q+ ++ IPK++ R+ +NI +FDF + E+M+++ L++ Sbjct: 223 YGKTVAQVILRWLTQKGIVAIPKTVRRERMKENISIFDFELTQEDMEKIATLDEG 277 >1MZR-A nrPDB Length = 296 Score = 337 bits (865), Expect = 3e-93, Method: Composition-based stats. Identities = 105/294 (35%), Positives = 162/294 (55%), Gaps = 33/294 (11%) Query: 4 SCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKED 63 + + L G MP +GLG W++ +V A++ AL VGYR ID AA Y NE +G+ALK Sbjct: 26 TVIKLQDGNVMPQLGLGVWQASNEEVITAIQKALEVGYRSIDTAAAYKNEEGVGKALKNA 85 Query: 64 VGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDN 123 +V REELF+T+KLWN H + AL +L LQL+Y+DLYLMHWP Sbjct: 86 -----SVNREELFITTKLWNDDH--KRPREALLDSLKKLQLDYIDLYLMHWPVP------ 132 Query: 124 PFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVL 183 HY E WK + L +GL++++G+ NF + ++ V P + Sbjct: 133 ------------AIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVIN 180 Query: 184 QVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGR 243 Q+E HP + Q +L A ++ ++SPL + + ++ V+ LA+KYG+ Sbjct: 181 QIELHPLMQQRQLHAWNATHKIQTESWSPLAQGGKG--------VFDQKVIRDLADKYGK 232 Query: 244 SPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWR 297 +PAQI++RW + ++ IPKS+TPSRI +N V+DF +E+ ++ L++ R Sbjct: 233 TPAQIVIRWHLDSGLVVIPKSVTPSRIAENFDVWDFRLDKDELGEIAKLDQGKR 286 >4MHB-A nrPDB Length = 297 Score = 328 bits (841), Expect = 2e-90, Method: Composition-based stats. Identities = 100/314 (31%), Positives = 165/314 (52%), Gaps = 41/314 (13%) Query: 5 CVLLHTGQKMPLIGLGTWK-SEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKED 63 V L+ G MPL+G G ++ + + + AV A+ GYR ID AA Y NE ++G ALK Sbjct: 17 TVKLNNGIAMPLLGFGVFQMTNTAECERAVIDAIETGYRLIDTAASYQNETQVGNALK-- 74 Query: 64 VGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDN 123 + R+ELF+T+KLW + E + ++L LQL+Y+DLYL+H PY G Sbjct: 75 ---LSGIARDELFITTKLWLQDTYYEGAKAQFERSLNRLQLDYVDLYLIHQPYGDVHG-- 129 Query: 124 PFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVL 183 W+A+E L G ++A+G+SNF+ ++ D+++ + PAV Sbjct: 130 -------------------AWRAMEELHQAGKIRAIGVSNFHPDRLADLMAFNKIIPAVN 170 Query: 184 QVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGR 243 Q+E +P+ Q + Q+RG++ A++P L + PV+ A+ EKYG+ Sbjct: 171 QIEVNPFNQQLHAVPWMQSRGIQPEAWAPFAEGRNG--------LFQNPVLTAIGEKYGK 222 Query: 244 SPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNK------NWR 297 S Q++LRW QR ++ + KS+ R+ +NI + DF S E+M Q+ AL+ + R Sbjct: 223 SVGQVVLRWIFQRGIVSLAKSVRKGRMEENINILDFELSAEDMLQIAALDTATSAFFSHR 282 Query: 298 YIVPMLTVDGKRVP 311 + + G+++ Sbjct: 283 DPAMVEWLTGRKLD 296 >3D3F-A nrPDB Length = 275 Score = 328 bits (840), Expect = 3e-90, Method: Composition-based stats. Identities = 122/295 (41%), Positives = 171/295 (57%), Gaps = 36/295 (12%) Query: 5 CVLLHTGQKMPLIGLGTWKSEPG-QVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKED 63 V LH G +MP GLG +K E G + +VK A+ GYR ID AAIY NE +G +KE Sbjct: 7 TVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNGYRSIDTAAIYKNEEGVGIGIKE- 65 Query: 64 VGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDN 123 V REELF+TSK+WN E A K+L LQL+YLDLYL+HWP + Sbjct: 66 ----SGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQLDYLDLYLIHWPGKDK---- 117 Query: 124 PFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVL 183 YK+TW+ALE L G ++A+G+SNF ++++L A ++P V Sbjct: 118 ----------------YKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPMVN 161 Query: 184 QVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGR 243 QVE HP L Q EL +C+ +G+++ A+SPL LL+ V+ +AEK+ + Sbjct: 162 QVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQ----------LLDNEVLTQIAEKHNK 211 Query: 244 SPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 298 S AQ++LRW +Q V+ IPKSI RI++N +FDF S E+M +++ALNK+ R Sbjct: 212 SVAQVILRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERV 266 >4OTK-A nrPDB Length = 318 Score = 315 bits (808), Expect = 1e-86, Method: Composition-based stats. Identities = 100/303 (33%), Positives = 144/303 (47%), Gaps = 33/303 (10%) Query: 2 AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 61 AA + L+ MP++GLG + + + AV AL +G R ID A YGNE +G A+ Sbjct: 45 AAPSITLNDEHTMPVLGLGVAELSDDETERAVSAALEIGCRLIDTAYAYGNEAAVGRAI- 103 Query: 62 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 V REELFVT+KL + A R +L L L+Y+DLYL+HWP Sbjct: 104 ----AASGVAREELFVTTKLATPDQGFTRSQEACRASLDRLGLDYVDLYLIHWPAPPVG- 158 Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPA 181 Y + W + +G +++G+SNF + I++++ + V PA Sbjct: 159 -----------------KYVDAWGGMIQSRGEGHARSIGVSNFTAENIENLIDLTFVTPA 201 Query: 182 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKY 241 V Q+E HP L Q+EL + +Y PL LL+ P V ++A +Y Sbjct: 202 VNQIELHPLLNQDELRKANAQHTVVTQSYCPLALGR----------LLDNPTVTSIASEY 251 Query: 242 GRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVP 301 ++PAQ+LLRW +Q + +S P RI N VFDF + E M L LN R Sbjct: 252 VKTPAQVLLRWNLQLGNAVVVRSARPERIASNFDVFDFELAAEHMDALGGLNDGTRVRED 311 Query: 302 MLT 304 LT Sbjct: 312 PLT 314 >4IJC-A nrPDB Length = 344 Score = 311 bits (796), Expect = 4e-85, Method: Composition-based stats. Identities = 109/314 (34%), Positives = 170/314 (54%), Gaps = 29/314 (9%) Query: 6 VLLHTGQKMPLIGLGTWKSEP--GQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKED 63 L+ G ++P +GLGT + K AVK A+ GYRHID A Y EP +GEA+KE Sbjct: 25 FSLNNGVRIPALGLGTANPHEKLAETKQAVKAAIKAGYRHIDTAWAYETEPFVGEAIKEL 84 Query: 64 VGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDN 123 + G + RE+LF+T+K+W ++V+ +L ++L L LEY+DL L HWP FE+ + Sbjct: 85 LEDGS-IKREDLFITTKVWPVLW--DEVDRSLNESLKALGLEYVDLLLQHWPLCFEKIKD 141 Query: 124 P--------FPKNADGTICYDST-HYKETWKALEALV---AKGLVQALGLSNFNSRQIDD 171 P P + G Y + Y ET+K LE + V+A+G+SNF+ ++ Sbjct: 142 PKGISGLVKTPVDDSGKTMYAADGDYLETYKQLEKIYLDPNDHRVRAIGVSNFSIEYLER 201 Query: 172 ILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEE 231 ++ V+P V QVE HP+L Q EL C + +TAYSPLGS L+ Sbjct: 202 LIKECRVKPTVNQVETHPHLPQMELRKFCFMHDILLTAYSPLGSHGAPN--------LKI 253 Query: 232 PVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNA 291 P+V LAEKY + +L+ + +++ I IP+S+ P RI +I+ + + +E+++LN Sbjct: 254 PLVKKLAEKYNVTGNDLLISYHIRQGTIVIPRSLNPVRISSSIEFA--SLTKDELQELND 311 Query: 292 LNKNW--RYIVPML 303 + + R+I Sbjct: 312 FGEKYPVRFIDEPF 325 >1A80-A nrPDB Length = 277 Score = 303 bits (776), Expect = 6e-83, Method: Composition-based stats. Identities = 93/292 (31%), Positives = 152/292 (52%), Gaps = 31/292 (10%) Query: 2 AASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 61 ++L+ G +P +G G +K P + AV+ AL VGYRHID AAIYGNE + Sbjct: 1 TVPSIVLNDGNSIPQLGYGVFKVPPADTQRAVEEALEVGYRHIDTAAIYGNEEGV----- 55 Query: 62 EDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERG 121 + R++LF+T+KLWN +H ++ A+ ++LA L L+ +DLYL+HWP Sbjct: 56 GAAIAASGIARDDLFITTKLWNDRHDGDEPAAAIAESLAKLALDQVDLYLVHWPTP---- 111 Query: 122 DNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPA 181 + +Y W+ + L A GL +++G+SN ++ I++ V PA Sbjct: 112 --------------AADNYVHAWEKMIELRAAGLTRSIGVSNHLVPHLERIVAATGVVPA 157 Query: 182 VLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKY 241 V Q+E HP Q E+ A +++ ++ PLG L V A A + Sbjct: 158 VNQIELHPAYQQREITDWAAAHDVKIESWGPLGQGKYD--------LFGAEPVTAAAAAH 209 Query: 242 GRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALN 293 G++PAQ +LRW +Q+ + PKS+ R+ +N+ VFDF + E+ ++A++ Sbjct: 210 GKTPAQAVLRWHLQKGFVVFPKSVRRERLEENLDVFDFDLTDTEIAAIDAMD 261 >3UP8-A nrPDB Length = 298 Score = 298 bits (762), Expect = 3e-81, Method: Composition-based stats. Identities = 84/295 (28%), Positives = 155/295 (52%), Gaps = 36/295 (12%) Query: 9 HTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGK 68 G +P +G GT++ +V + AL +G+RH+D A IYGNE E+GEA+++ Sbjct: 29 SNGANIPALGFGTFRMSGAEVLRILPQALKLGFRHVDTAQIYGNEAEVGEAIQK-----S 83 Query: 69 AVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKN 128 +PR ++F+T+K+W + + ++ ++L L+ +++DL L+HWP Sbjct: 84 GIPRADVFLTTKVWVDNYRHDAFIASVDESLRKLRTDHVDLLLLHWPG------------ 131 Query: 129 ADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECH 188 E AL + G V+ +G+SNFN+ Q+++ ++ A QVE H Sbjct: 132 -------SDVPMAERIGALNEVRNAGKVRHIGISNFNTTQMEEAARLSDAPIATNQVEYH 184 Query: 189 PYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQI 248 PYL Q +++ + G+ +T+Y + + + +P++ + ++G++ AQ+ Sbjct: 185 PYLDQTKVLQTARRLGMSLTSYYAMANG----------KVPADPLLTEIGGRHGKTAAQV 234 Query: 249 LLRWQVQRK-VICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNK-NWRYIVP 301 LRW VQ++ VI + K+ T +R+ +N +FDF + EEM + L + N R + P Sbjct: 235 ALRWLVQQQDVIVLSKTATEARLKENFAIFDFALTREEMAAVRELARPNGRIVNP 289 >3WG6-A nrPDB Length = 307 Score = 266 bits (679), Expect = 1e-71, Method: Composition-based stats. Identities = 95/315 (30%), Positives = 144/315 (45%), Gaps = 43/315 (13%) Query: 1 MAASCVLLHTGQKMPLIGLGTW--------KSEPGQVKAAVKYALSVGYRHIDCAAIYGN 52 +A L G K+P + GT Q+ ++ AL G+RHID A IYG Sbjct: 6 LAGKEFKLSNGNKIPAVAFGTGTKYFKRGHNDLDKQLIGTLELALRSGFRHIDGAEIYGT 65 Query: 53 EPEIGEALKEDVGPGKAVPREELFVTSKLWNTKHHPE-------DVEPALRKTLADLQLE 105 EIG ALK + R+++F+T K + H + + AL+ L DL LE Sbjct: 66 NKEIGIALKN-----VGLNRKDVFITDKYNSGNHTYDGKHSKHQNPYNALKADLEDLGLE 120 Query: 106 YLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFN 165 Y+DLYL+H+PY E+ E W+ LE +GL + +G+SNF Sbjct: 121 YVDLYLIHFPYISEKS--------------HGFDLVEAWRYLERAKNEGLARNIGVSNFT 166 Query: 166 SRQIDDILSVASVR-PAVLQVECHPYLAQNE--LIAHCQARGLEVTAYSPLGSSDRAWRD 222 + IL + P V Q+E YL ++ + Q +G+ + AY PLG + Sbjct: 167 IENLKSILDANTDSIPVVNQIEFSAYLQDQTPGIVEYSQQQGILIEAYGPLGPITQGRPG 226 Query: 223 PDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFS 282 P + V+ L+EKY R+ QILLRW +QR ++ I + RI +++FDF Sbjct: 227 PL------DKVLSKLSEKYKRNEGQILLRWVLQRGILPITTTSKEERINDVLEIFDFELD 280 Query: 283 PEEMKQLNALNKNWR 297 E+ Q+ + K Sbjct: 281 KEDEDQITKVGKEKT 295 >4H8N-A nrPDB Length = 310 Score = 253 bits (647), Expect = 6e-68, Method: Composition-based stats. Identities = 87/308 (28%), Positives = 150/308 (48%), Gaps = 41/308 (13%) Query: 4 SCVLLHTGQKMP-LIGLGT-W---KSEPGQVKAAVK---YALSVGYRHIDCAAIYGNEPE 55 +G+++ +G GT W ++ V L +G+RHID A Y + E Sbjct: 12 KTFRTKSGKEISIALGTGTKWKQAQTINDVSTELVDNILLGLKLGFRHIDTAEAYNTQKE 71 Query: 56 IGEALKEDVGPGKAVPREELFVTSKL---WNT-KHHPEDVEPALRKTLADLQLEYLDLYL 111 +GEALK VPRE+++VT+K W + K + + ++ K LA L ++Y+DL+L Sbjct: 72 VGEALKR-----TDVPREDIWVTTKYSPGWGSIKAYSKSPSDSIDKALAQLGVDYVDLFL 126 Query: 112 MHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDD 171 +H P+ + + ++ W+AL G V+ +G+SN ++ Sbjct: 127 IHSPFFTTEQTHGY-------------TLEQAWEALVEAKKAGKVREIGISNAAIPHLEK 173 Query: 172 ILSV---ASVRPAVLQVECHPYLAQNE--LIAHCQARGLEVTAYSPLGSSDRAWRDPDEP 226 + + P V Q+E HP+L ++ CQ G+ V A+SPL R E Sbjct: 174 LFAASPSPEYYPVVNQIEFHPFLQNQSKNIVRFCQEHGILVEAFSPLAPLARV-----ET 228 Query: 227 VLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEM 286 L E + LAEKY ++ AQ+LLR+ +QR ++ + S SR+ +++ +FDF + EE+ Sbjct: 229 NALAE-TLKRLAEKYKKTEAQVLLRYTLQRGILPVTTSSKESRLKESLNLFDFELTDEEV 287 Query: 287 KQLNALNK 294 ++N + Sbjct: 288 NEINKIGD 295 >1LQA-A nrPDB Length = 346 Score = 214 bits (545), Expect = 4e-56, Method: Composition-based stats. Identities = 79/348 (22%), Positives = 137/348 (39%), Gaps = 64/348 (18%) Query: 9 HTGQKMPLIGLGTW----KSEPGQVKAAVKYALSVGYRHIDCAAIYGN--EPEIGEALKE 62 H+ ++ +GLGT ++ A + YA++ G ID A +Y PE + Sbjct: 8 HSSLEVSTLGLGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYPVPPRPETQGLTET 67 Query: 63 DVGP--GKAVPREELFVTSKLWNTK------------HHPEDVEPALRKTLADLQLEYLD 108 VG K RE+L + SK+ +++ AL +L LQ +YLD Sbjct: 68 YVGNWLAKHGSREKLIIASKVSGPSRNNDKGIRPDQALDRKNIREALHDSLKRLQTDYLD 127 Query: 109 LYLMHWPYAFERGDNPFPKNADGTICYDSTH------YKETWKALEALVAKGLVQALGLS 162 LY +HWP P N G + Y T +T AL G ++ +G+S Sbjct: 128 LYQVHWPQR--------PTNCFGKLGYSWTDSAPAVSLLDTLDALAEYQRAGKIRYIGVS 179 Query: 163 NFNSRQIDDILSVASVR--PAVLQVECHPYLAQNE-----LIAHCQARGLEVTAYSPLGS 215 N + + L +A P ++ ++ +PY N L Q G+E+ AYS LG Sbjct: 180 NETAFGVMRYLHLADKHDLPRIVTIQ-NPYSLLNRSFEVGLAEVSQYEGVELLAYSCLGF 238 Query: 216 S--------------------DRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQ 255 R R E + +A ++G PAQ+ L + + Sbjct: 239 GTLTGKYLNGAKPAGARNTLFSRFTRYSGEQTQKAVAAYVDIARRHGLDPAQMALAFVRR 298 Query: 256 RKVIC--IPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVP 301 + + + + T ++ NI+ S + + ++ A+++ + Y P Sbjct: 299 QPFVASTLLGATTMDQLKTNIESLHLELSEDVLAEIEAVHQVYTYPAP 346 >1PYF-A nrPDB Length = 312 Score = 200 bits (508), Expect = 9e-52, Method: Composition-based stats. Identities = 73/321 (22%), Positives = 128/321 (39%), Gaps = 73/321 (22%) Query: 17 IGLGTW---------KSEPGQVKAAVKYALSVGYRHIDCAAIYG---NEPEIGEALKEDV 64 IGLGT K V+ A+ G +D A IYG +E IGE L+E Sbjct: 16 IGLGTNAVGGHNLYPNLNEETGKELVREAIRNGVTMLDTAYIYGIGRSEELIGEVLRE-- 73 Query: 65 GPGKAVPREELFVTSKLWNT--------KHHPEDVEPALRKTLADLQLEYLDLYLMHWPY 116 RE++ + +K + + P+ ++ ++ ++L L +Y+DL+ +H+P Sbjct: 74 -----FNREDVVIATKAAHRKQGNDFVFDNSPDFLKKSVDESLKRLNTDYIDLFYIHFP- 127 Query: 117 AFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVA 176 D PK+ E AL + G ++++G+SNF+ Q+ + Sbjct: 128 -----DEHTPKD-------------EAVNALNEMKKAGKIRSIGVSNFSLEQLKEANKDG 169 Query: 177 SVRPAVLQVECHPYLAQNE--LIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPV- 233 V VLQ E + + E + + + Y PL S A + ++ E + Sbjct: 170 LVD--VLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTEDTTFPEGDLR 227 Query: 234 --------------------VLALAEKYGRSPAQILLRWQVQRK--VICIPKSITPSRIL 271 + +AEK+ I+L W + R I IP + +++ Sbjct: 228 NEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDILIPGAKRADQLI 287 Query: 272 QNIKVFDFTFSPEEMKQLNAL 292 NIK D T S E++ ++ L Sbjct: 288 DNIKTADVTLSQEDISFIDKL 308 >1PZ1-A nrPDB Length = 333 Score = 199 bits (506), Expect = 2e-51, Method: Composition-based stats. Identities = 75/329 (22%), Positives = 135/329 (41%), Gaps = 68/329 (20%) Query: 10 TGQKMPLIGLGTWK--------SEPGQVKAAVKYALSVGYRHIDCAAIYG---NEPEIGE 58 TG + IGLGTW ++ ++ AL G ID A YG +E +G+ Sbjct: 9 TGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAALDQGITLIDTAPAYGFGQSEEIVGK 68 Query: 59 ALKEDVGPGKAVPREELFVTSKL---WNTKH-----HPEDVEPALRKTLADLQLEYLDLY 110 A+KE + R+++ + +K W + + + +L LQ +Y+DLY Sbjct: 69 AIKEYM------KRDQVILATKTALDWKNNQLFRHANRARIVEEVENSLKRLQTDYIDLY 122 Query: 111 LMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQID 170 +HWP +ET + ++ L G ++A+G+SNF+ Q+D Sbjct: 123 QVHWPDPL-------------------VPIEETAEVMKELYDAGKIRAIGVSNFSIEQMD 163 Query: 171 DILSVA---SVRPAVLQVE------CHPYLAQNE---LIAHCQARGL---EVTAYSPLGS 215 +VA +++P E PY N+ L+ RGL ++T Sbjct: 164 TFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEEYTFEG 223 Query: 216 SDRAWRDP--DEPVLLEEPVVLALAEK-----YGRSPAQILLRWQVQRK--VICIPKSIT 266 D DP +P E + +K YG+S + +RW + + I + + Sbjct: 224 DDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADIALWGARK 283 Query: 267 PSRILQNIKVFDFTFSPEEMKQLNALNKN 295 P ++ ++ +T + E+ K +N + +N Sbjct: 284 PGQLEALSEITGWTLNSEDQKDINTILEN 312 >3N6Q-A nrPDB Length = 346 Score = 190 bits (482), Expect = 9e-49, Method: Composition-based stats. Identities = 67/334 (20%), Positives = 135/334 (40%), Gaps = 74/334 (22%) Query: 9 HTGQKMPLIGLGTWKSEP-----GQVKAAVKYALSVGYRHIDCAAIYG-----NEPEIGE 58 +G ++P + LG W + +A ++ A +G H D A YG E G Sbjct: 20 KSGLRLPALSLGLWHNFGHVNALESQRAILRKAFDLGITHFDLANNYGPPPGSAEENFGR 79 Query: 59 ALKEDVGPGKAVPREELFVTSK----LW----NTKHHPEDVEPALRKTLADLQLEYLDLY 110 L+ED R+EL +++K +W + + + +L ++L + LEY+D++ Sbjct: 80 LLREDFAA----YRDELIISTKAGYDMWPGPYGSGGSRKYLLASLDQSLKRMGLEYVDIF 135 Query: 111 LMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQID 170 H ++T +ET AL V G +G+S+++ + Sbjct: 136 YSH-------------------RVDENTPMEETASALAHAVQSGKALYVGISSYSPERTQ 176 Query: 171 DILSVASVRPAVLQVECHPY------LAQNELIAHCQARGLEVTAYSPLGSS-------- 216 ++ + L + Y + ++ L+ Q G+ A++PL Sbjct: 177 KMVELLREWKIPLLIHQPSYNLLNRWVDKSGLLDTLQNNGVGCIAFTPLAQGLLTGKYLN 236 Query: 217 -----DRAWRDPDE-----PVLLEEPVVLAL------AEKYGRSPAQILLRWQV--QRKV 258 R R+ ++ P +L E + +L A++ G+S AQ+ L W + R Sbjct: 237 GIPQDSRMHREGNKVRGLTPKMLTEANLNSLRLLNEMAQQRGQSMAQMALSWLLKDDRVT 296 Query: 259 ICIPKSITPSRILQNIKVF-DFTFSPEEMKQLNA 291 + + ++ +N++ + TFS +E+ Q++ Sbjct: 297 SVLIGASRAEQLEENVQALNNLTFSTKELAQIDQ 330 >3EB3-A nrPDB Length = 327 Score = 177 bits (450), Expect = 5e-45, Method: Composition-based stats. Identities = 66/340 (19%), Positives = 131/340 (38%), Gaps = 69/340 (20%) Query: 7 LLHTGQKMPLIGLGTWKSEPGQ-----VKAAVKYALSVGYRHIDCAAIYGNEPEIGEALK 61 L +G ++ +GLGTW + GQ + + A G D A +Y E + Sbjct: 8 LGKSGLRVSCLGLGTWVTFGGQITDEMAEHLMTLAYDNGINLFDTAEVYAAGKA--EVVL 65 Query: 62 EDVGPGKAVPREELFVTSKLWN-------TKHHPEDVEPALRKTLADLQLEYLDLYLMHW 114 ++ K R L +T+K++ + + L+ +L LQLEY+D+ Sbjct: 66 GNIIKKKGWRRSSLVITTKIFAGGKAETERGLSRKHIIEGLKASLERLQLEYVDVVF--- 122 Query: 115 PYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILS 174 + P P +T +ET +A+ ++ +G+ G S ++S +I + S Sbjct: 123 ------ANRPDP----------NTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYS 166 Query: 175 VAS----VRPAVLQVECHPYLAQN---ELIAHCQARGLEVTAYSPLGSS----------- 216 VA + P Q E H + + +L G+ +SPL Sbjct: 167 VARQFNLIPPICEQAEYHMFQREKVEVQLPELFHKIGVGAMTWSPLACGIVSGKYDSGIP 226 Query: 217 ------DRAWRDPDEPVLLEE--------PVVLALAEKYGRSPAQILLRWQVQ-RKV-IC 260 + ++ + +L EE + A+AE+ G + Q+ + W ++ V Sbjct: 227 PYSRASLKGYQWLKDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSV 286 Query: 261 IPKSITPSRILQNIKVFDF--TFSPEEMKQLNALNKNWRY 298 + + ++++NI S + +++++ N Y Sbjct: 287 LLGASNAEQLMENIGAIQVLPKLSSSIVHEIDSILGNKPY 326 >1GVE-A nrPDB Length = 327 Score = 151 bits (382), Expect = 3e-37, Method: Composition-based stats. Identities = 69/337 (20%), Positives = 118/337 (35%), Gaps = 74/337 (21%) Query: 15 PLIGLGTW----KSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAV 70 P LG + + A+V+ L G+ ID A +Y N E + D+G G Sbjct: 6 PATVLGAMEMGRRMDVTSSSASVRAFLQRGHTEIDTAFVYANGQS--ETILGDLGLGLGR 63 Query: 71 PREELFVTSK---LWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPK 127 ++ + +K ++ P DV L +L LQ +DL+ +H+P Sbjct: 64 SGCKVKIATKAAPMFGKTLKPADVRFQLETSLKRLQCPRVDLFYLHFP------------ 111 Query: 128 NADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS----VRPAVL 183 T +ET +A L +G LGLSN+ S ++ +I ++ + P V Sbjct: 112 -------DHGTPIEETLQACHQLHQEGKFVELGLSNYVSWEVAEICTLCKKNGWIMPTVY 164 Query: 184 QVECHPYLAQ--NELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEP--------- 232 Q + Q EL + GL A++PL R + + P Sbjct: 165 QGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGRYKYQDKDGKNPESRFFGNPF 224 Query: 233 -------------------VVLALAEKYGRSPAQI---LLRW---QVQ----RKVICIPK 263 V AL YG + + +RW Q + I Sbjct: 225 SQLYMDRYWKEEHFNGIALVEKALKTTYGPTAPSMISAAVRWMYHHSQLKGTQGDAVILG 284 Query: 264 SITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 300 + ++ QN+ + P E ++A ++ W + Sbjct: 285 MSSLEQLEQNLAL--VEEGPLEPAVVDAFDQAWNLVA 319 >2CLP-A nrPDB Length = 347 Score = 142 bits (357), Expect = 3e-34, Method: Composition-based stats. Identities = 68/337 (20%), Positives = 113/337 (33%), Gaps = 74/337 (21%) Query: 15 PLIGLGTW----KSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAV 70 P LG + + A + L G+ ID A +Y E + +G Sbjct: 26 PATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQS--ETILGGLGLRLGG 83 Query: 71 PREELFVTSK---LWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPK 127 + + +K L+ P+ + L +L LQ +DL+ +H P Sbjct: 84 SDCRVKIDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMP------------ 131 Query: 128 NADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS----VRPAVL 183 ST +ET +A L +G LGLSN+ + ++ +I ++ + P V Sbjct: 132 -------DHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVY 184 Query: 184 QVECHPYLAQ--NELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEP--------- 232 Q + Q EL + GL A++PL + E ++P Sbjct: 185 QGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKDGKQPVGRFFGNTW 244 Query: 233 -------------------VVLALAEKYGRSPAQI---LLRW-----QVQ--RKVICIPK 263 V AL YG S + LRW Q+Q I Sbjct: 245 AEMYRNRYWKEHHFEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILG 304 Query: 264 SITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 300 + ++ QN+ P E ++A N+ W + Sbjct: 305 MSSLEQLEQNLAAA--EEGPLEPAVVDAFNQAWHLVA 339 >2BP1-A nrPDB Length = 360 Score = 134 bits (337), Expect = 5e-32, Method: Composition-based stats. Identities = 71/333 (21%), Positives = 115/333 (34%), Gaps = 74/333 (22%) Query: 19 LGTW----KSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAVPREE 74 LGT + + AAV+ L G+ +D A +Y + E + +G G Sbjct: 43 LGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQS--ETILGGLGLGLGGGDCR 100 Query: 75 LFVTSKL--W-NTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADG 131 + + +K W P+ V L +L LQ +DL+ +H P Sbjct: 101 VKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAP---------------- 144 Query: 132 TICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS----VRPAVLQVEC 187 T +ET A + L +G LGLSN+ S ++ +I ++ + P V Q Sbjct: 145 ---DHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMY 201 Query: 188 HPYLAQ--NELIAHCQARGLEVTAYSPLGSS---------------------DRAWRDPD 224 + Q EL + GL AY+PL +W + Sbjct: 202 NATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETY 261 Query: 225 EPVLLEEPVVLALA-------EKYGRSPAQI---LLRW-----QVQ--RKVICIPKSITP 267 +E A+A YG S + LRW Q+Q I + Sbjct: 262 RNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSL 321 Query: 268 SRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 300 ++ QN+ P E ++A N+ W + Sbjct: 322 EQLEQNLAAT--EEGPLEPAVVDAFNQAWHLVA 352 >2C91-A nrPDB Length = 338 Score = 134 bits (337), Expect = 6e-32, Method: Composition-based stats. Identities = 72/333 (21%), Positives = 118/333 (35%), Gaps = 74/333 (22%) Query: 15 PLIGLGTW----KSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAV 70 P LGT + + A+V+ L G+ +D A +Y + E + +G G Sbjct: 17 PATVLGTMEMGRRMDASASAASVRAFLERGHSELDTAFMYCDGQS--ENILGGLGLGLGS 74 Query: 71 PREELFVTSKL--W-NTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPK 127 + + +K W P+ + L +L LQ +DL+ +H P Sbjct: 75 GDCTVKIATKANPWEGKSLKPDSIRSQLETSLKRLQCPRVDLFYLHAP------------ 122 Query: 128 NADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS----VRPAVL 183 ST +ET A L +G LGLSN+ S ++ +I ++ + P V Sbjct: 123 -------DHSTPVEETLCACHQLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVY 175 Query: 184 QVECHPYLAQ--NELIAHCQARGLEVTAYSPLGSS---------------------DRAW 220 Q + Q EL+ + GL AY+PL W Sbjct: 176 QGMYNATTRQVEAELLPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNNW 235 Query: 221 RDPDEPVLLEEPVVLALA--EK-----YGRSPAQI---LLRW-----QVQ--RKVICIPK 263 + +E A+A EK YG + ++ LRW Q+Q R I Sbjct: 236 AETYRNRFWKEHHFEAIALVEKALQTTYGTNAPRMTSAALRWMYHHSQLQGTRGDAVILG 295 Query: 264 SITPSRILQNIKVFDFTFSPEEMKQLNALNKNW 296 + ++ QN+ P E + A ++ W Sbjct: 296 MSSLEQLEQNLAAT--EEGPLEPAVVEAFDQAW 326 >4R9O-A nrPDB Length = 301 Score = 118 bits (297), Expect = 2e-27, Method: Composition-based stats. Identities = 57/291 (19%), Positives = 106/291 (36%), Gaps = 48/291 (16%) Query: 22 WKSEPGQVKAAVKYALSVGYRHIDCAAIYGN---EPEIGEALKEDVGPGKAVPREELFVT 78 W Q+ + ++ L +G +D A IYG E GEAL RE+L + Sbjct: 30 WNMSARQLVSFIEEHLDLGVTTVDHADIYGGYQCEAAFGEALTLAPHL-----REKLQIV 84 Query: 79 SK------------LWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFP 126 +K L + + + ++L +L +YLD+ L+H P D Sbjct: 85 TKCGIATTARAENKLGHYITDRRHIILSAEQSLKNLATDYLDMLLIHRPDPLMDAD---- 140 Query: 127 KNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVE 186 + +A + L G V+ G+SNF Q + S A QVE Sbjct: 141 ---------------DVAEAFQHLHQSGKVRHFGVSNFTPAQFTLLQSRLPFTLATNQVE 185 Query: 187 CHPYLA---QNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGR 243 P + + Q + A+S LG + +P+ E + +A++ Sbjct: 186 ISPVHQPLLLDGTLDQLQQLRIRPMAWSCLGGGRLFNDEAYQPLRQE---LSVIAQELNA 242 Query: 244 SPA-QILLRWQVQRKVICIP--KSITPSRILQNIKVFDFTFSPEEMKQLNA 291 S Q++ W ++ +P S R+ ++ + + ++ ++ Sbjct: 243 SSIEQVVYAWILRLPSQPLPIIGSGKIERVRAALEAETLSLTRQQWFRIRK 293 >1OG6-A nrPDB Length = 298 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 62/291 (21%), Positives = 105/291 (36%), Gaps = 48/291 (16%) Query: 22 WKSEPGQVKAAVKYALSVGYRHIDCAAIYGN---EPEIGEALKEDVGPGKAVPREELFVT 78 W Q+ + ++ L +G +D A IYG E GEALK RE + + Sbjct: 27 WNMSARQLVSFIEEHLDLGVTTVDHADIYGGYQCEAAFGEALKLAPHL-----RERMEIV 81 Query: 79 SK------------LWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFP 126 SK + + + + + ++L +L ++LDL L+H P D Sbjct: 82 SKCGIATTAREENVIGHYITDRDHIIKSAEQSLINLATDHLDLLLIHRPDPLMDAD---- 137 Query: 127 KNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVE 186 E A + L G V+ G+SNF Q + S A QVE Sbjct: 138 ---------------EVADAFKHLHQSGKVRHFGVSNFTPAQFALLQSRLPFTLATNQVE 182 Query: 187 CHPYLA---QNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGR 243 P + + Q + A+S LG D +P+ E VV AE+ Sbjct: 183 ISPVHQPLLLDGTLDQLQQLRVRPMAWSCLGGGRLFNDDYFQPLRDELAVV---AEELNA 239 Query: 244 -SPAQILLRWQVQRKVICIP--KSITPSRILQNIKVFDFTFSPEEMKQLNA 291 S Q++ W ++ +P S R+ ++ + ++ ++ Sbjct: 240 GSIEQVVNAWVLRLPSQPLPIIGSGKIERVRAAVEAETLKMTRQQWFRIRK 290 >4EXA-A nrPDB Length = 292 Score = 72.7 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 46/245 (18%), Positives = 81/245 (33%), Gaps = 57/245 (23%) Query: 10 TGQKMPLIGLGTWK---------------SEPGQVKAAVKYALSVGYRHIDCAAIYG-NE 53 TG + +GLGT K + + + A +G ID A YG +E Sbjct: 38 TGLAVSPLGLGTVKFGRDQGVKYPSGFTIPDDREAADLLALARDLGINLIDTAPAYGRSE 97 Query: 54 PEIGEALKEDVGPGKAVPREELFVTSKL--------WNTKHHPEDVEPALRKTLADLQLE 105 +G L+ RE + SK+ ++ ++L L+ + Sbjct: 98 ERLGPLLRG--------QREHWVIVSKVGEEFVDGQSVFDFSAAHTRRSVERSLKRLETD 149 Query: 106 YLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFN 165 ++L L+H + + +++ E + L AL +GL+ A GLS Sbjct: 150 RIELVLVH-------------SDGNDLDILENS---EVYPTLAALKREGLIGAYGLSGKT 193 Query: 166 SRQIDDILSV---ASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRD 222 L A V + + A+ +I + A + L S Sbjct: 194 VEGGLRALREGDCAMVTYNLNER------AERPVIEYAAAHAKGILVKKALASGHACLGA 247 Query: 223 PDEPV 227 +PV Sbjct: 248 GQDPV 252 >4EHI-A nrPDB Length = 534 Score = 30.3 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 8/18 (44%), Positives = 12/18 (66%) Query: 41 YRHIDCAAIYGNEPEIGE 58 ++HID +Y N E+GE Sbjct: 383 FKHIDGGFVYQNSDEVGE 400 >4BKP-A nrPDB Length = 336 Score = 29.9 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 10/26 (38%), Positives = 19/26 (73%), Gaps = 1/26 (3%) Query: 56 IGEALKEDVGPGKAVPREE-LFVTSK 80 +G+A+++ V G +P E+ +FV+SK Sbjct: 34 VGKAIQKVVADGAGLPGEDWVFVSSK 59 >5ZF1-A nrPDB Length = 301 Score = 29.9 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 8/23 (34%), Positives = 15/23 (65%) Query: 187 CHPYLAQNELIAHCQARGLEVTA 209 CH Y +++L A+C+ + +TA Sbjct: 197 CHRYTPKDKLEAYCRNADIIITA 219 >4FO0-A nrPDB Length = 593 Score = 29.6 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 18/65 (27%), Positives = 24/65 (36%), Gaps = 7/65 (10%) Query: 80 KLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTH 139 K NT HHPE + L + LD Y +HWP RG G++ Sbjct: 124 KWTNTSHHPEYLVGE-----EALYVNPLDCYNIHWPIR--RGQLNIHPGPGGSLTAVLAD 176 Query: 140 YKETW 144 + W Sbjct: 177 IEVIW 181 >4NPH-A nrPDB Length = 351 Score = 29.2 bits (64), Expect = 2.8, Method: Composition-based stats. Identities = 14/53 (26%), Positives = 21/53 (39%), Gaps = 8/53 (15%) Query: 10 TGQKMPLIGLGTWK-----SEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIG 57 G+++P + WK P V+ + L G R ID A G +G Sbjct: 22 DGRELPDV---CWKDYDAMPPPAMVRQPITQPLMTGIRAIDSVATCGEGQRVG 71 >5GJU-A nrPDB Length = 205 Score = 28.8 bits (63), Expect = 3.1, Method: Composition-based stats. Identities = 28/148 (18%), Positives = 50/148 (33%), Gaps = 21/148 (14%) Query: 169 IDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVL 228 ++ + + +P+ +Q EC P+L + G TA L + P + Sbjct: 13 LEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLQNLDPELKAPQI 72 Query: 229 LEEPVVLALA----------EKYGRSPAQILL----RWQVQ-----RKVICIPKSITPSR 269 L LA K+ R + L R+ VQ + + TP R Sbjct: 73 LVLAPTRELAVQVAEAMTDFSKHMRGVNVVALYGGQRYDVQLRALRQGPQIVVG--TPGR 130 Query: 270 ILQNIKVFDFTFSPEEMKQLNALNKNWR 297 +L ++K S L+ ++ R Sbjct: 131 LLDHLKRGTLDLSKLSGLVLDEADEMLR 158 >4YWJ-A nrPDB Length = 276 Score = 28.8 bits (63), Expect = 3.4, Method: Composition-based stats. Identities = 11/55 (20%), Positives = 20/55 (36%) Query: 128 NADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAV 182 + + D TH T K +E +G + F++ + + A P V Sbjct: 75 CEEFDVLIDFTHPSVTLKNIEQCRKARRAMVIGTTGFSADEKLLLAEAAKDIPIV 129 >3IVU-A nrPDB Length = 423 Score = 28.4 bits (62), Expect = 3.9, Method: Composition-based stats. Identities = 16/60 (26%), Positives = 23/60 (38%), Gaps = 4/60 (6%) Query: 22 WKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGPGKAV-PREELFVTSK 80 + ++ G A AL G HID +I G G + V RE ++T K Sbjct: 230 FHNDTGMAIANAYCALEAGATHIDT-SILGIGERNGITPLGALLARMYVTDRE--YITHK 286 >3MMA-A nrPDB Length = 418 Score = 28.4 bits (62), Expect = 4.0, Method: Composition-based stats. Identities = 18/63 (28%), Positives = 23/63 (36%), Gaps = 4/63 (6%) Query: 87 HPEDVEPALRKTLA---DLQLEYLD-LYLMHWPYAFERGDNPFPKNADGTICYDSTHYKE 142 P E A TL DL + Y D L+ WPY F+ P + + Sbjct: 178 GPALCEFACYDTLELCYDLTMTYQDELHRPMWPYKFKIKCAGCPNDCVASKARSDFAIIG 237 Query: 143 TWK 145 TWK Sbjct: 238 TWK 240 >2BS2-A nrPDB Length = 660 Score = 28.4 bits (62), Expect = 4.3, Method: Composition-based stats. Identities = 10/52 (19%), Positives = 22/52 (42%), Gaps = 5/52 (9%) Query: 128 NADGTICYDSTHYKETWKALEALVAKGLVQALGLSN---FNSRQIDDILSVA 176 + + I D H ++ K LE L + +G+ N + ++++ V Sbjct: 475 DDNVGIFRDGPHLEKAVKELEELYK--KSKNVGIKNKRLHANPELEEAYRVP 524 >4WO8-A nrPDB Length = 716 Score = 28.4 bits (62), Expect = 4.6, Method: Composition-based stats. Identities = 13/54 (24%), Positives = 22/54 (40%), Gaps = 2/54 (3%) Query: 194 NELIAHCQARGLEVTAYSP--LGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSP 245 ++ + L + P LG++ RA P+L P + EK+G P Sbjct: 251 SKSLKFAFNDRLGFITFCPSNLGTTLRASVHAKIPMLASLPNFKEICEKHGIQP 304 >3Q3N-A nrPDB Length = 500 Score = 28.4 bits (62), Expect = 4.9, Method: Composition-based stats. Identities = 9/31 (29%), Positives = 15/31 (48%), Gaps = 3/31 (9%) Query: 84 TKHHPEDVEPALRKTLADLQLE---YLDLYL 111 + E + ++L DL L+ Y DL+L Sbjct: 291 KEFMYEWIIGQFERSLIDLGLDKPWYWDLFL 321 >1JPH-A nrPDB Length = 388 Score = 28.0 bits (61), Expect = 6.3, Method: Composition-based stats. Identities = 13/51 (25%), Positives = 26/51 (50%), Gaps = 2/51 (3%) Query: 16 LIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEALKEDVGP 66 ++GL W P + + V +++ D A+Y +E EIG+ +K+ + Sbjct: 300 VVGL-DWTVAPKKARECVGKTVTLQGNL-DPCALYASEEEIGQLVKQMLDD 348 >5H82-A nrPDB Length = 389 Score = 27.6 bits (60), Expect = 7.9, Method: Composition-based stats. Identities = 12/43 (27%), Positives = 17/43 (39%), Gaps = 4/43 (9%) Query: 204 GLEVTAY----SPLGSSDRAWRDPDEPVLLEEPVVLALAEKYG 242 G+ V AY SPL R + + E +L A K+ Sbjct: 307 GVAVEAYELPVSPLLMGRRKFVGSISGTMKETQEMLDFAAKHN 349 >4P22-A nrPDB Length = 446 Score = 27.6 bits (60), Expect = 8.0, Method: Composition-based stats. Identities = 9/51 (17%), Positives = 19/51 (37%), Gaps = 4/51 (7%) Query: 158 ALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVT 208 + ++ + ++D LS V P Q + C RG+++ Sbjct: 148 YVPVTAYTGPLVEDFLSGFQVVVLTNT----PLEDQLRVGEFCHNRGIKLV 194 >6F0K-D nrPDB Length = 217 Score = 27.6 bits (60), Expect = 8.3, Method: Composition-based stats. Identities = 8/22 (36%), Positives = 11/22 (50%) Query: 24 SEPGQVKAAVKYALSVGYRHID 45 S+P + A + GYRH D Sbjct: 31 SDPAALLHAARQVRKAGYRHFD 52 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.143 0.428 Lambda K H 0.267 0.0438 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,750,239 Number of Sequences: 36641 Number of extensions: 648015 Number of successful extensions: 2209 Number of sequences better than 10.0: 72 Number of HSP's better than 10.0 without gapping: 103 Number of HSP's successfully gapped in prelim test: 30 Number of HSP's that attempted gapping in prelim test: 1758 Number of HSP's gapped (non-prelim): 137 length of query: 325 length of database: 10,336,785 effective HSP length: 97 effective length of query: 228 effective length of database: 6,782,608 effective search space: 1546434624 effective search space used: 1546434624 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 59 (27.2 bits)