BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P13995 (350 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5TC4-A nrPDB 639 0.0 5ZF1-A nrPDB 345 2e-95 3L07-A nrPDB 252 1e-67 5NHS-A nrPDB 252 2e-67 5O2A-B nrPDB 251 3e-67 6APE-A nrPDB 239 2e-63 6DEB-A nrPDB 239 2e-63 4A5O-A nrPDB 236 1e-62 4CJX-A nrPDB 212 2e-55 4A26-A nrPDB 204 4e-53 1DIA-A nrPDB 196 9e-51 2C2Y-A nrPDB 194 3e-50 4B4V-A nrPDB 194 7e-50 3NGX-A nrPDB 134 7e-32 1EDZ-A nrPDB 77 1e-14 2F96-A nrPDB 32 0.28 5MMI-S nrPDB 30 1.1 4QQS-A nrPDB 30 1.5 2EEZ-A nrPDB 30 2.0 1SMK-A nrPDB 29 3.2 3X2F-A nrPDB 29 3.3 6NF9-A nrPDB 29 3.9 5LZS-EE nrPDB 28 4.4 5XXB-Z nrPDB 28 5.2 3DWF-A nrPDB 28 6.3 4BFR-A nrPDB 27 9.6 >5TC4-A nrPDB Length = 316 Score = 639 bits (1648), Expect = 0.0, Method: Compositional matrix adjust. Identities = 315/315 (100%), Positives = 315/315 (100%) Query: 36 EAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVV 95 EAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVV Sbjct: 2 EAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVV 61 Query: 96 GINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVD 155 GINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVD Sbjct: 62 GINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVD 121 Query: 156 GFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHT 215 GFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHT Sbjct: 122 GFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHT 181 Query: 216 DGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVG 275 DGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVG Sbjct: 182 DGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVG 241 Query: 276 INRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLE 335 INRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLE Sbjct: 242 INRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLE 301 Query: 336 EREVLKSKELGVATN 350 EREVLKSKELGVATN Sbjct: 302 EREVLKSKELGVATN 316 >5ZF1-A nrPDB Length = 301 Score = 345 bits (884), Expect = 2e-95, Method: Compositional matrix adjust. Identities = 165/294 (56%), Positives = 226/294 (76%), Gaps = 2/294 (0%) Query: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVG 96 A ++ G+ LA +IK+E++Q++ +WV+ GN+ P + I+VG++PASH+YV NK AA VG Sbjct: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61 Query: 97 INSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDG 156 I++ TI + + I+EE+LL+ I LN D++VDG+LVQLP+P+ I+ERR+C+A++P+KD+DG Sbjct: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121 Query: 157 FHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 216 FH+IN+GR+C+D +++PAT V E++KR I T G+N VV GRSKNVGMPIAM+LH+D Sbjct: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181 Query: 217 GAHERP-GGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVG 275 HE G DATVTI HRYTPK++L+ + ADI+I+A G+P LI ADM+K GA +IDVG Sbjct: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241 Query: 276 INRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAK 329 I D K +LVGDVD+E V + AG ITPVPGGVGPMTVAMLM NT AA+ Sbjct: 242 ITTRTDE-NGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQ 294 >3L07-A nrPDB Length = 285 Score = 252 bits (644), Expect = 1e-67, Method: Compositional matrix adjust. Identities = 138/300 (46%), Positives = 186/300 (62%), Gaps = 17/300 (5%) Query: 35 NEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAV 94 N ++I G+ L++ +K+ + +V+E+ P L I+VG +PAS +YV +K +A A Sbjct: 2 NAMILIDGKSLSKDLKERLATQVQEYKHHTAITPKLVAIIVGNDPASKTYVASKEKACAQ 61 Query: 95 VGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDV 154 VGI+S+ I P +E ELL LI++LNND +V +LVQLPLP HI++ + ++ P+KDV Sbjct: 62 VGIDSQVITLPEHTTESELLELIDQLNNDSSVHAILVQLPLPAHINKNNVIYSIKPEKDV 121 Query: 155 DGFHVINVGRMCL-DQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLL 213 DGFH NVGR+ L D+ + TP G+ +++ GI T G VV G S VG P++ LL Sbjct: 122 DGFHPTNVGRLQLRDKKCLESCTPKGIMTMLREYGIKTEGAYAVVVGASNVVGKPVSQLL 181 Query: 214 HTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVID 273 ATVT HR+T LK HT ADI+I A G PN ITADM+KEGA VID Sbjct: 182 --------LNAKATVTTCHRFT--TDLKSHTTKADILIVAVGKPNFITADMVKEGAVVID 231 Query: 274 VGINRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLR 333 VGIN V K+VGDVDF V+ K ITPVPGGVGPMT+ L+ NT A+++ R Sbjct: 232 VGINHVDG------KIVGDVDFAAVKDKVAAITPVPGGVGPMTITELLYNTFQCAQELNR 285 >5NHS-A nrPDB Length = 296 Score = 252 bits (644), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 137/297 (46%), Positives = 185/297 (62%), Gaps = 13/297 (4%) Query: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVG 96 A ++ GR++A+ + E++ V+ +A+G RP L+V+LVG +PAS YV NK RAA VG Sbjct: 12 ARILDGRRIAEDLLDELKTRVDARLAAGQPRPGLAVVLVGGDPASTVYVRNKRRAAEKVG 71 Query: 97 INSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDG 156 I + PA E ELL+LI++LN D + G+LVQLPLP D R+ + + P KDVDG Sbjct: 72 IEAFDYDLPAGTGEAELLSLIDQLNADPKIHGILVQLPLPGIADASRLIHRIDPRKDVDG 131 Query: 157 FHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 216 FH NVG + L ++ + P TP G+ ++ T P G+N + G S +VG P+A+ L Sbjct: 132 FHPQNVGHLALREFGLRPCTPRGIVTLLAHTDQPVRGRNATIVGVSNHVGRPMALELLIA 191 Query: 217 GAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGI 276 G TV+ H++TP + L+ H ADI++ A G P LI D +K GA VIDVGI Sbjct: 192 G--------CTVSCCHKFTPADVLQTHVRDADILVVAVGRPGLIPGDWVKPGAVVIDVGI 243 Query: 277 NRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLR 333 NR+ D +LVGDV FE Q+A +ITPVPGGVGPMTVA LM+NTI AA LR Sbjct: 244 NRLDD-----GRLVGDVGFEAAAQRASWITPVPGGVGPMTVATLMQNTIEAADAALR 295 >5O2A-B nrPDB Length = 289 Score = 251 bits (641), Expect = 3e-67, Method: Compositional matrix adjust. Identities = 138/292 (47%), Positives = 184/292 (63%), Gaps = 15/292 (5%) Query: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVG 96 A +I G+ +AQQ++ EV Q+V+ +A+G + P L+V+LVG NPAS YV +K +A VG Sbjct: 4 AKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEVG 63 Query: 97 INSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDG 156 S + P + SE ELL LI+ LN D+ +DG+LV LPLP ID ++ + PDKDVDG Sbjct: 64 FVSRSYDLPETTSEAELLELIDTLNADNTIDGILVHLPLPAGIDNVKVLERIHPDKDVDG 123 Query: 157 FHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 216 FH NVGR+C + P TP G+ +++R I T G N VV G S VG P++M L Sbjct: 124 FHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLLA 183 Query: 217 GAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGI 276 G T T++HR+T + L+ H AD++I A G P I D IKEGA VIDVGI Sbjct: 184 G--------CTTTVTHRFT--KNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVGI 233 Query: 277 NRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAA 328 NR+ + K+VGDV FE ++A YITPVPGGVGPMTVA L++NT+ A Sbjct: 234 NRLEN-----GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 280 >6APE-A nrPDB Length = 298 Score = 239 bits (609), Expect = 2e-63, Method: Compositional matrix adjust. Identities = 125/296 (42%), Positives = 190/296 (64%), Gaps = 15/296 (5%) Query: 38 VVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGI 97 V++ G+ LA I+++++ +++ +KRP L+VILVG++PAS +YV K +A VG+ Sbjct: 15 VLLDGQALAYSIEKDLKNKIQIITVQVHKRPKLAVILVGKDPASITYVNMKIKACERVGM 74 Query: 98 NSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGF 157 + + +++E ELL+LI N D N+ G+LVQLPLP HID + + A+ P KDVDGF Sbjct: 75 DFDLKTLQENVTEAELLSLIKDYNTDQNISGVLVQLPLPRHIDSKMVLEAIDPSKDVDGF 134 Query: 158 HVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDG 217 H +N+G++C + S LPATP GV ++K I GK+V + G S +G P++ML+ G Sbjct: 135 HPLNIGKLCTQKESFLPATPMGVMRLLKHYHIEIKGKDVAIIGASNIIGKPLSMLMLNAG 194 Query: 218 AHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGIN 277 A+V++ H T + + +T ADIV G P+LI A M+K+GA V+D+GIN Sbjct: 195 --------ASVSVCHILT--KDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGIN 244 Query: 278 RVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLR 333 ++D ++VGDVDF ++ AG+ITPVP GVGPMT+ L++NT+IA +K R Sbjct: 245 HLND-----GRIVGDVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQQR 295 >6DEB-A nrPDB Length = 285 Score = 239 bits (609), Expect = 2e-63, Method: Compositional matrix adjust. Identities = 136/300 (45%), Positives = 192/300 (64%), Gaps = 17/300 (5%) Query: 35 NEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAV 94 N ++ G+ L+ +IK+E++++ +++ S L+VILVG+NPAS +YV +K +A Sbjct: 2 NAMTLLDGKALSAKIKEELKEK-NQFLKSKGIESCLAVILVGDNPASQTYVKSKAKACEE 60 Query: 95 VGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDV 154 GI S +I++ ELL LIN LN+DD+V G+LVQLPLP+HI + I ++ KDV Sbjct: 61 CGIKSLVYHLNENITQNELLALINTLNHDDSVHGILVQLPLPDHICKDLILESIISSKDV 120 Query: 155 DGFHVINVGRMCLD-QYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLL 213 DGFH INVG + L + LP TP GV +++K I GK+ V+ G S VG P+A +L Sbjct: 121 DGFHPINVGYLNLGLESGFLPCTPLGVMKLLKAYEIDLEGKDAVIIGASNIVGRPMATML 180 Query: 214 HTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVID 273 G ATV++ H T + L +T AD++I AAG NL+ +DM+KEG V+D Sbjct: 181 LNAG--------ATVSVCHIKT--KDLSLYTRQADLIIVAAGCVNLLRSDMVKEGVIVVD 230 Query: 274 VGINRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLR 333 VGINR+ K+VGDVDFE V +K+ YITPVPGGVGPMT+AML++NT+ +AK L Sbjct: 231 VGINRLE-----SGKIVGDVDFEEVSKKSSYITPVPGGVGPMTIAMLLENTVKSAKNRLN 285 >4A5O-A nrPDB Length = 286 Score = 236 bits (601), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 131/295 (44%), Positives = 181/295 (61%), Gaps = 15/295 (5%) Query: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVG 96 A +I G+ +A ++Q++ Q V E G + P L+VILVG +PAS YV +K + VG Sbjct: 5 AQLIDGKAIAANLRQQIAQRVTERRQQGLRVPGLAVILVGTDPASQVYVAHKRKDCEEVG 64 Query: 97 INSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDG 156 S+ PA S+++LL LI++LN+D +DG+LVQLPLP H+D + + PDKDVDG Sbjct: 65 FLSQAYDLPAETSQDDLLALIDRLNDDPAIDGILVQLPLPAHLDASLLLERIHPDKDVDG 124 Query: 157 FHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 216 FH N+GR+ + P TP G+ ++ TG G + VV G S VG P+A+ L Sbjct: 125 FHPYNIGRLAQRMPLLRPCTPKGIMTLLASTGADLYGMDAVVVGASNIVGRPMALELLL- 183 Query: 217 GAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGI 276 G TVT++HR+T L H AD+V+ AAG P L+ + IKEGA VIDVGI Sbjct: 184 -------GGCTVTVTHRFT--RDLADHVSRADLVVVAAGKPGLVKGEWIKEGAIVIDVGI 234 Query: 277 NRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKV 331 NR A +LVGDV++E Q+A +ITPVPGGVGPMT A L++NT+ AA+ + Sbjct: 235 NR-----QADGRLVGDVEYEVAAQRASWITPVPGGVGPMTRACLLENTLHAAEHL 284 >4CJX-A nrPDB Length = 319 Score = 212 bits (540), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 125/303 (41%), Positives = 185/303 (61%), Gaps = 14/303 (4%) Query: 36 EAVVISGRKLAQQIKQEVRQEVE--EWVASGNKRPHLSVILVGENPASHSYVLNKTRAAA 93 EAVVI GR +A+ I++E+ +EV E G +RP LS I+ G+ S +YV K +AAA Sbjct: 24 EAVVIDGRAVAKAIQKELTEEVALLERRYKG-RRPGLSTIICGKRKDSQTYVRLKRKAAA 82 Query: 94 VVGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKD 153 G + ++ PA++++E L + +LN ++ ++VQLPLP HID+ + + P+KD Sbjct: 83 ACGFRNFSVELPANVTQEALEREVIRLNEEEACHSIVVQLPLPPHIDKVAALSKIKPEKD 142 Query: 154 VDGFHVINVGRMCLDQY--SMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAM 211 D +NVG++ + + +++P T V E+++ +G+ GK VVV GR G+P+A Sbjct: 143 ADCLLPVNVGQLHIRERNPAIVPCTASAVMELLRCSGVEICGKRVVVLGRGDIAGLPVAT 202 Query: 212 LLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAV 271 LL + DATVT+ H TP + +DIV+SAAG P L+ + IK GAAV Sbjct: 203 LLANE--------DATVTVVHSATPLCDIADIVRASDIVVSAAGQPGLVRGEWIKLGAAV 254 Query: 272 IDVGINRVHDPVTAKP-KLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKK 330 IDVG V DP +LVGDV F+ R++A YITPVPGGVGP+TV+ML+KNT+ K+ Sbjct: 255 IDVGTTPVADPSKVPGYRLVGDVCFDVARKRAAYITPVPGGVGPVTVSMLLKNTLTMFKR 314 Query: 331 VLR 333 +R Sbjct: 315 SVR 317 >4A26-A nrPDB Length = 300 Score = 204 bits (519), Expect = 4e-53, Method: Compositional matrix adjust. Identities = 128/300 (42%), Positives = 172/300 (57%), Gaps = 12/300 (4%) Query: 37 AVVISGRKLAQQIKQEVRQEVEEWVA-SGNKRPHLSVILVGENPASHSYVLNKTRAAAVV 95 A +I G+ +A I+ E++ +V G + P L+ I+VG+ S YV K +AAA V Sbjct: 6 AQIIDGKAIAAAIRSELKDKVAALRELYGGRVPGLASIIVGQRMDSKKYVQLKHKAAAEV 65 Query: 96 GINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVD 155 G+ S + P IS+E L + KLNND N G++VQLPLP+H++E R + P KD D Sbjct: 66 GMASFNVELPEDISQEVLEVNVEKLNNDPNCHGIIVQLPLPKHLNENRAIEKIHPHKDAD 125 Query: 156 GFHVINVGRMCLD--QYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLL 213 +NVG + + P T GV ++KR GI GK VV GRS VG P+A LL Sbjct: 126 ALLPVNVGLLHYKGREPPFTPCTAKGVIVLLKRCGIEMAGKRAVVLGRSNIVGAPVAALL 185 Query: 214 HTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVID 273 + +ATVTI H T E + + ADIVI+A G P + + IKEGAAV+D Sbjct: 186 MKE--------NATVTIVHSGTSTEDMIDYLRTADIVIAAMGQPGYVKGEWIKEGAAVVD 237 Query: 274 VGINRVHDPVTAKP-KLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVL 332 VG V DP +LVGDV FE +A +I+PVPGGVGPMT+AML++NT+ A K L Sbjct: 238 VGTTPVPDPSRKDGYRLVGDVCFEEAAARAAWISPVPGGVGPMTIAMLLENTLEAFKAAL 297 >1DIA-A nrPDB Length = 306 Score = 196 bits (499), Expect = 9e-51, Method: Compositional matrix adjust. Identities = 120/305 (39%), Positives = 177/305 (58%), Gaps = 20/305 (6%) Query: 37 AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAAVV 95 A +++G++++ QI+ ++ +V + P L+++ VG S+ Y+ K +AA + Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63 Query: 96 GINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEH--IDERRICNAVSPDKD 153 GI + I P + +E E++ I LN D V G LVQLPL I+ + NA++P+KD Sbjct: 64 GIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKD 123 Query: 154 VDGFHVINVGRMCLDQYS--MLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAM 211 VDG IN GR+ + +P TP G E+IK TG+P G++ VV GRSK VG P+ Sbjct: 124 VDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHD 183 Query: 212 LLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAV 271 LL + +ATVT H T L + DI++ A G P ++ + IK GA V Sbjct: 184 LLLWN--------NATVTTCHSKT--AHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIV 233 Query: 272 IDVGINRVHDPVTAKP---KLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAA 328 ID GIN V D KP K+VGDV ++ +++A +ITPVPGGVGPMTVAMLM++T+ +A Sbjct: 234 IDCGINYVPD--DKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESA 291 Query: 329 KKVLR 333 K+ L Sbjct: 292 KRFLE 296 >2C2Y-A nrPDB Length = 281 Score = 194 bits (494), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 120/294 (40%), Positives = 171/294 (58%), Gaps = 16/294 (5%) Query: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVG 96 A+++ G+ +I +++Q V A+G + P L ILVG++P S +YV K A VG Sbjct: 3 AIMLDGKATRDEIFGDLKQRVAALDAAG-RTPGLGTILVGDDPGSQAYVRGKHADCAKVG 61 Query: 97 INSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDG 156 I S PA IS L I++LN + + G +VQLPLP+H+DE V P KD DG Sbjct: 62 ITSIRRDLPADISTATLNETIDELNANPDCTGYIVQLPLPKHLDENAALERVDPAKDADG 121 Query: 157 FHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 216 H N+GR+ L + LP TP G+ +++R I G +VVV GR VG P+ +LL Sbjct: 122 LHPTNLGRLVLGTPAPLPCTPRGIVHLLRRYDISIAGAHVVVIGRGVTVGRPLGLLL--- 178 Query: 217 GAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGI 276 R +ATVT+ H T L T ADIV++A G+ +L+TADM++ GAAVIDVG+ Sbjct: 179 ---TRRSENATVTLCH--TGTRDLPALTRQADIVVAAVGVAHLLTADMVRPGAAVIDVGV 233 Query: 277 NRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKK 330 +R D LVGDV + V + AG+++P PGGVGP+T A L+ N + A++ Sbjct: 234 SRTDD------GLVGDVHPD-VWELAGHVSPNPGGVGPLTRAFLLTNVVELAER 280 >4B4V-A nrPDB Length = 303 Score = 194 bits (492), Expect = 7e-50, Method: Compositional matrix adjust. Identities = 120/296 (40%), Positives = 169/296 (57%), Gaps = 16/296 (5%) Query: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVG 96 A+V+ GR LA+QI++ + VE A + P L+ ILVG++ AS +YV K A VG Sbjct: 23 ALVLDGRALAKQIEENLLVRVEALKAKTGRTPILATILVGDDGASATYVRMKGNACRRVG 82 Query: 97 INSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDG 156 ++S I P + E+LL I KLN + +V G+L+Q P+P IDER +A+S KDVDG Sbjct: 83 MDSLKIELPQETTTEQLLAEIEKLNANPDVHGILLQHPVPAQIDERACFDAISLAKDVDG 142 Query: 157 FHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 216 + GRM + + + ATP G+ I+K I GK+ VV GRS +G P+AM+L Sbjct: 143 VTCLGFGRMAMGEAAYGSATPAGIMTILKENNIEIAGKHAVVVGRSAILGKPMAMMLLQ- 201 Query: 217 GAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGI 276 +ATVTI H T + L + ADI++ A G LI D IK+GA V+D G Sbjct: 202 -------ANATVTICHSRT--QNLPELVKQADIIVGAVGKAELIQKDWIKQGAVVVDAGF 252 Query: 277 NRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVL 332 + P VGD+ +G+ + A TPVPGGVGPMT+ L++ T+ AA+K L Sbjct: 253 H----PRDGGG--VGDIQLQGIEEIASAYTPVPGGVGPMTITTLIRQTVEAAEKAL 302 >3NGX-A nrPDB Length = 276 Score = 134 bits (336), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 89/284 (31%), Positives = 147/284 (51%), Gaps = 19/284 (6%) Query: 46 AQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKP 105 ++I ++ + + + P L +I +G+N A+ Y K R +GI + + K Sbjct: 6 GEEIAEKKAENLHGIIERSGLEPSLKLIQIGDNEAASIYARAKIRRGKKIGIAVD-LEKY 64 Query: 106 ASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRM 165 IS ++LL I+ L D ++G++++ PLP+ D I + KDVD N G + Sbjct: 65 DDISMKDLLKRIDDLAKDPQINGIMIENPLPKGFDYYEIVRNIPYYKDVDALSPYNQGLI 124 Query: 166 CLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGD 225 L++ ++PATP V +I+ G V + RS VG P++M+L + Sbjct: 125 ALNREFLVPATPRAVIDIMDYYGYHE--NTVTIVNRSPVVGRPLSMMLLNR--------N 174 Query: 226 ATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTA 285 TV++ H T + + T + IV+ A G P + +M+ G+ VIDVGIN V+D Sbjct: 175 YTVSVCHSKT--KDIGSMTRSSKIVVVAVGRPGFLNREMVTPGSVVIDVGINYVND---- 228 Query: 286 KPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAK 329 K+VGD +FE + + ITPVPGGVGP+T +++N + AA+ Sbjct: 229 --KVVGDANFEDLSEYVEAITPVPGGVGPITATNILENVVKAAE 270 >1EDZ-A nrPDB Length = 320 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 80/329 (24%), Positives = 144/329 (43%), Gaps = 59/329 (17%) Query: 40 ISGRKLAQQIKQEVRQEVEEWVASGNKR-PHLSVILVGENPASHSYVLNKTRAAAVVGIN 98 I K+A+ E+ VEE+ + N + P L L +PA+ Y + + +G Sbjct: 8 ILASKVAETFNTEIINNVEEYKKTHNGQGPLLVGFLANNDPAAKMYATWTQKTSESMGFR 67 Query: 99 SET-IMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGF 157 + +++ EE ++ + N DD+V+G++V P+ + ++ + V +KDV+G Sbjct: 68 YDLRVIEDKDFLEEAII----QANGDDSVNGIMVYFPVFGNAQDQYLQQVVCKEKDVEGL 123 Query: 158 HVINVGRM-----CLDQ----YSMLPATPWGVWEIIKRTGIPT---------LGKNVVVA 199 + + + LD+ S+LP TP + +I++ I GK +V Sbjct: 124 NHVYYQNLYHNVRYLDKENRLKSILPCTPLAIVKILEFLKIYNNLLPEGNRLYGKKCIVI 183 Query: 200 GRSKNVGMPIAMLLHTDGA----------HERPGGDATVTISH------RYTPKEQLKKH 243 RS+ VG P+A LL DGA + G++ H Y+ ++ LKK Sbjct: 184 NRSEIVGRPLAALLANDGATVYSVDVNNIQKFTRGESLKLNKHHVEDLGEYS-EDLLKKC 242 Query: 244 TILADIVISAAGIPNL-ITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQKA 302 ++ +D+VI+ N + IKEGA I+ + + V++KA Sbjct: 243 SLDSDVVITGVPSENYKFPTEYIKEGAVCINFACTKNFS--------------DDVKEKA 288 Query: 303 GYITPVPGGVGPMTVAMLMKNTIIAAKKV 331 P+ G V T+AML++N + + V Sbjct: 289 SLYVPMTGKV---TIAMLLRNMLRLVRNV 314 >2F96-A nrPDB Length = 224 Score = 32.3 bits (72), Expect = 0.28, Method: Compositional matrix adjust. Identities = 31/113 (27%), Positives = 44/113 (38%), Gaps = 16/113 (14%) Query: 14 LLQPAHSCSLRLRPFHLAAVRNEAVVISGRKLAQQIKQEVRQEV----------EEWVAS 63 L P H+ R+ PF A + A+ +G KL ++ V++E + A+ Sbjct: 63 FLFPEHTYFFRIEPFEGANIEPAALEFTGIKLDHPLRMAVQEEAALTEIFRGIRKALKAN 122 Query: 64 GNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNL 116 G KR ILVG N + LN A A GI +S L L Sbjct: 123 GCKR----AILVGHNSSFDLGFLNA--AVARTGIKRNPFHPFSSFDTATLAGL 169 >5MMI-S nrPDB Length = 256 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 13/36 (36%), Positives = 23/36 (63%) Query: 39 VISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVIL 74 V + R+ Q+I +E++ E EE+ N++P LS +L Sbjct: 54 VAAKRRRFQEIPEELKAEFEEFQRPPNQKPQLSDVL 89 >4QQS-A nrPDB Length = 315 Score = 30.0 bits (66), Expect = 1.5, Method: Compositional matrix adjust. Identities = 25/74 (33%), Positives = 33/74 (44%), Gaps = 10/74 (13%) Query: 176 TPWGVWEIIKRTGIPTLGKNVV--VAGRSKNV------GMPIAMLLHTDGAHERPGGDAT 227 TP G W IK +G P L K + ++G N G + ++ HT + PGGD T Sbjct: 229 TPLGPW--IKYSGNPILSKRMDKGISGPGHNSVTVSPDGSELFVVYHTHTYPDSPGGDRT 286 Query: 228 VTISHRYTPKEQLK 241 V I Y LK Sbjct: 287 VNIDRLYFEDGILK 300 >2EEZ-A nrPDB Length = 369 Score = 29.6 bits (65), Expect = 2.0, Method: Compositional matrix adjust. Identities = 32/108 (29%), Positives = 52/108 (48%), Gaps = 15/108 (13%) Query: 240 LKKHTILADIVISA-----AGIPNLITADMI---KEGAAVIDVGINRVHDPVTAKPKLVG 291 +KK AD++I A A P L+T DM+ KEGA ++DV +++ T +P Sbjct: 223 IKKSVQHADLLIGAVLVPGAKAPKLVTRDMLSLMKEGAVIVDVAVDQGGCVETIRPTTHA 282 Query: 292 DVDF--EGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEER 337 + + +GV + +PG V P T + N + VL+L E+ Sbjct: 283 EPTYVVDGVVHYG--VANMPGAV-PRTSTFALTNQTL--PYVLKLAEK 325 >1SMK-A nrPDB Length = 326 Score = 28.9 bits (63), Expect = 3.2, Method: Compositional matrix adjust. Identities = 45/179 (25%), Positives = 74/179 (41%), Gaps = 42/179 (23%) Query: 193 GKNVVVAGRSKNVGMPIAML---------LHTDGAHERPGGDATVTISHR--------YT 235 G V + G + +G P+AML LH PG T ISH + Sbjct: 8 GFKVAILGAAGGIGQPLAMLMKMNPLVSVLHLYDVVNAPG--VTADISHMDTGAVVRGFL 65 Query: 236 PKEQLKKHTILADIVISAAGI---PNLITADMIKEGAAVIDV---GI---------NRVH 280 ++QL+ D++I AG+ P + D+ K A ++ GI N + Sbjct: 66 GQQQLEAALTGMDLIIVPAGVPRKPGMTRDDLFKINAGIVKTLCEGIAKCCPRAIVNLIS 125 Query: 281 DPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEEREV 339 +PV + + + V +KAG P +G + ++ NT +A +VL L+ R+V Sbjct: 126 NPVNSTVPIAAE-----VFKKAGTYDP-KRLLGVTMLDVVRANTFVA--EVLGLDPRDV 176 >3X2F-A nrPDB Length = 411 Score = 28.9 bits (63), Expect = 3.3, Method: Compositional matrix adjust. Identities = 36/117 (30%), Positives = 55/117 (47%), Gaps = 10/117 (8%) Query: 175 ATPWGVWE-IIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAH----ERPGGDATVT 229 T W+ I++ T + GKNVVVAG G IA+ GA E A Sbjct: 178 GTGQSTWDAIMRNTNLLVAGKNVVVAGYGW-CGRGIALRAAGLGARVIVTEVDPVKAVEA 236 Query: 230 ISHRYTPKEQLKKHTILADIVISAAGIPNLITADMI---KEGAAVIDVGINRVHDPV 283 I +T +K+ +AD VI+A+G ++++ + I K+GA + + G V PV Sbjct: 237 IMDGFTVM-PMKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPV 292 >6NF9-A nrPDB Length = 576 Score = 28.9 bits (63), Expect = 3.9, Method: Compositional matrix adjust. Identities = 19/53 (35%), Positives = 28/53 (52%), Gaps = 2/53 (3%) Query: 130 LVQLPLPEHIDERRICNAVSPDKDVDGFHVIN-VGRMCLDQYSMLPATPWGVW 181 LV L +PEH RRI N ++ + V G V + + +S++ A WGVW Sbjct: 67 LVHLNMPEHESYRRI-NVLNSEAGVAGQMVQDDAHSQMVTPWSLVDANAWGVW 118 >5LZS-EE nrPDB Length = 263 Score = 28.5 bits (62), Expect = 4.4, Method: Compositional matrix adjust. Identities = 13/32 (40%), Positives = 18/32 (56%) Query: 232 HRYTPKEQLKKHTILADIVISAAGIPNLITAD 263 HR TP+E K + I + GIP+L+T D Sbjct: 112 HRITPEEAKYKLCKVRKIFVGTKGIPHLVTHD 143 >5XXB-Z nrPDB Length = 147 Score = 28.1 bits (61), Expect = 5.2, Method: Compositional matrix adjust. Identities = 26/76 (34%), Positives = 34/76 (44%), Gaps = 3/76 (3%) Query: 199 AGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPN 258 GR K GM M ++ D H PG V + H + K Q T+ D + S Sbjct: 30 GGRGKAGGMH-HMRINYDKYH--PGYFGKVGMRHYHLLKNQYTCPTVNVDKLWSLVSPAT 86 Query: 259 LITADMIKEGAAVIDV 274 L A+ K+ AAVIDV Sbjct: 87 LEKAEQSKDKAAVIDV 102 >3DWF-A nrPDB Length = 276 Score = 28.1 bits (61), Expect = 6.3, Method: Compositional matrix adjust. Identities = 14/27 (51%), Positives = 16/27 (59%) Query: 193 GKNVVVAGRSKNVGMPIAMLLHTDGAH 219 GK V+V G SK +G IA L GAH Sbjct: 11 GKKVIVTGASKGIGREIAYHLAKMGAH 37 >4BFR-A nrPDB Length = 952 Score = 27.3 bits (59), Expect = 9.6, Method: Compositional matrix adjust. Identities = 12/51 (23%), Positives = 29/51 (56%) Query: 85 VLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPL 135 V++ + A + +NS + A+ +++ LLN + + N+ D++D + + L Sbjct: 735 VVSTSETIADIQLNSSNVAATAAFNKDALLNWLKEYNSGDDLDRAIEEFTL 785 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5TC4-A nrPDB 443 e-125 5ZF1-A nrPDB 393 e-110 5O2A-B nrPDB 388 e-108 4A5O-A nrPDB 386 e-108 5NHS-A nrPDB 385 e-107 3L07-A nrPDB 375 e-104 6DEB-A nrPDB 375 e-104 4A26-A nrPDB 375 e-104 6APE-A nrPDB 367 e-102 4CJX-A nrPDB 352 1e-97 1DIA-A nrPDB 348 2e-96 4B4V-A nrPDB 345 1e-95 2C2Y-A nrPDB 338 2e-93 3NGX-A nrPDB 303 9e-83 1EDZ-A nrPDB 260 6e-70 Sequences not found previously or not previously below threshold: 6GBN-A nrPDB 40 0.002 2EEZ-A nrPDB 39 0.003 6APH-A nrPDB 38 0.007 3OND-A nrPDB 38 0.007 4WLE-A nrPDB 36 0.027 2DZD-A nrPDB 36 0.031 1MLD-A nrPDB 36 0.031 4WJI-A nrPDB 35 0.040 2VHY-A nrPDB 34 0.083 5JXW-A nrPDB 34 0.099 4DIO-A nrPDB 33 0.13 3X2F-A nrPDB 33 0.17 2RIR-A nrPDB 33 0.18 5UXF-A nrPDB 33 0.24 1PJB-A nrPDB 32 0.31 1SMK-A nrPDB 32 0.39 2ZOY-A nrPDB 32 0.58 3KC2-A nrPDB 32 0.59 2HE8-A nrPDB 32 0.61 3F9I-A nrPDB 32 0.61 4JQA-A nrPDB 31 0.81 5JM5-A nrPDB 30 1.1 3RAC-A nrPDB 30 1.4 6D4C-A nrPDB 30 1.5 3D64-A nrPDB 30 1.7 5CEE-A nrPDB 30 1.9 4UR8-A nrPDB 30 1.9 4BVA-A nrPDB 30 1.9 2D0I-A nrPDB 30 2.0 3K8Z-A nrPDB 29 2.4 5KKP-A nrPDB 29 2.9 2FVL-A nrPDB 29 3.0 5KS8-A nrPDB 29 3.1 3G1R-A nrPDB 29 3.7 1O5I-A nrPDB 29 3.8 5OVL-A nrPDB 28 4.1 3KXP-A nrPDB 28 4.6 4JA0-A nrPDB 28 4.6 1NHQ-A nrPDB 28 4.7 5M65-A nrPDB 28 4.8 4PPM-A nrPDB 28 4.8 5OVJ-A nrPDB 28 5.2 3RX4-A nrPDB 28 5.5 2X9N-A nrPDB 28 8.1 4H0F-A nrPDB 28 8.2 1UZM-A nrPDB 27 9.1 1JEO-A nrPDB 27 9.6 4Y4M-A nrPDB 27 9.8 >5TC4-A nrPDB Length = 316 Score = 443 bits (1139), Expect = e-125, Method: Composition-based stats. Identities = 315/315 (100%), Positives = 315/315 (100%) Query: 36 EAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVV 95 EAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVV Sbjct: 2 EAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVV 61 Query: 96 GINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVD 155 GINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVD Sbjct: 62 GINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVD 121 Query: 156 GFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHT 215 GFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHT Sbjct: 122 GFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHT 181 Query: 216 DGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVG 275 DGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVG Sbjct: 182 DGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVG 241 Query: 276 INRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLE 335 INRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLE Sbjct: 242 INRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLE 301 Query: 336 EREVLKSKELGVATN 350 EREVLKSKELGVATN Sbjct: 302 EREVLKSKELGVATN 316 >5ZF1-A nrPDB Length = 301 Score = 393 bits (1009), Expect = e-110, Method: Composition-based stats. Identities = 165/298 (55%), Positives = 226/298 (75%), Gaps = 2/298 (0%) Query: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVG 96 A ++ G+ LA +IK+E++Q++ +WV+ GN+ P + I+VG++PASH+YV NK AA VG Sbjct: 2 ARILDGKALAMEIKKELKQKIAQWVSLGNRAPTIRCIIVGDDPASHTYVRNKVEAAKFVG 61 Query: 97 INSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDG 156 I++ TI + + I+EE+LL+ I LN D++VDG+LVQLP+P+ I+ERR+C+A++P+KD+DG Sbjct: 62 IDALTINRDSDITEEQLLSEIQNLNEDNSVDGILVQLPVPDTINERRVCDAIAPEKDIDG 121 Query: 157 FHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 216 FH+IN+GR+C+D +++PAT V E++KR I T G+N VV GRSKNVGMPIAM+LH+D Sbjct: 122 FHIINIGRLCVDLPTIVPATALAVVEMLKRFNIDTFGRNAVVIGRSKNVGMPIAMMLHSD 181 Query: 217 GAHERP-GGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVG 275 HE G DATVTI HRYTPK++L+ + ADI+I+A G+P LI ADM+K GA +IDVG Sbjct: 182 KRHESGLGMDATVTICHRYTPKDKLEAYCRNADIIITATGLPKLIKADMVKPGATIIDVG 241 Query: 276 INRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLR 333 I D K +LVGDVD+E V + AG ITPVPGGVGPMTVAMLM NT AA+ Sbjct: 242 ITTRTDE-NGKSRLVGDVDYEEVSKIAGAITPVPGGVGPMTVAMLMHNTFQAAQSQAN 298 >5O2A-B nrPDB Length = 289 Score = 388 bits (996), Expect = e-108, Method: Composition-based stats. Identities = 138/293 (47%), Positives = 184/293 (62%), Gaps = 15/293 (5%) Query: 36 EAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVV 95 A +I G+ +AQQ++ EV Q+V+ +A+G + P L+V+LVG NPAS YV +K +A V Sbjct: 3 AAKIIDGKTIAQQVRSEVAQKVQARIAAGLRAPGLAVVLVGSNPASQIYVASKRKACEEV 62 Query: 96 GINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVD 155 G S + P + SE ELL LI+ LN D+ +DG+LV LPLP ID ++ + PDKDVD Sbjct: 63 GFVSRSYDLPETTSEAELLELIDTLNADNTIDGILVHLPLPAGIDNVKVLERIHPDKDVD 122 Query: 156 GFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHT 215 GFH NVGR+C + P TP G+ +++R I T G N VV G S VG P++M L Sbjct: 123 GFHPYNVGRLCQRAPRLRPCTPRGIVTLLERYNIDTFGLNAVVIGASNIVGRPMSMELLL 182 Query: 216 DGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVG 275 G T T++HR+T + L+ H AD++I A G P I D IKEGA VIDVG Sbjct: 183 AG--------CTTTVTHRFT--KNLRHHVENADLLIVAVGKPGFIPGDWIKEGAIVIDVG 232 Query: 276 INRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAA 328 INR+ + K+VGDV FE ++A YITPVPGGVGPMTVA L++NT+ A Sbjct: 233 INRLEN-----GKVVGDVVFEDAAKRASYITPVPGGVGPMTVATLIENTLQAC 280 >4A5O-A nrPDB Length = 286 Score = 386 bits (991), Expect = e-108, Method: Composition-based stats. Identities = 131/295 (44%), Positives = 181/295 (61%), Gaps = 15/295 (5%) Query: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVG 96 A +I G+ +A ++Q++ Q V E G + P L+VILVG +PAS YV +K + VG Sbjct: 5 AQLIDGKAIAANLRQQIAQRVTERRQQGLRVPGLAVILVGTDPASQVYVAHKRKDCEEVG 64 Query: 97 INSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDG 156 S+ PA S+++LL LI++LN+D +DG+LVQLPLP H+D + + PDKDVDG Sbjct: 65 FLSQAYDLPAETSQDDLLALIDRLNDDPAIDGILVQLPLPAHLDASLLLERIHPDKDVDG 124 Query: 157 FHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 216 FH N+GR+ + P TP G+ ++ TG G + VV G S VG P+A+ L Sbjct: 125 FHPYNIGRLAQRMPLLRPCTPKGIMTLLASTGADLYGMDAVVVGASNIVGRPMALELLLG 184 Query: 217 GAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGI 276 G TVT++HR+T L H AD+V+ AAG P L+ + IKEGA VIDVGI Sbjct: 185 G--------CTVTVTHRFT--RDLADHVSRADLVVVAAGKPGLVKGEWIKEGAIVIDVGI 234 Query: 277 NRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKV 331 NR D +LVGDV++E Q+A +ITPVPGGVGPMT A L++NT+ AA+ + Sbjct: 235 NRQAD-----GRLVGDVEYEVAAQRASWITPVPGGVGPMTRACLLENTLHAAEHL 284 >5NHS-A nrPDB Length = 296 Score = 385 bits (989), Expect = e-107, Method: Composition-based stats. Identities = 137/297 (46%), Positives = 185/297 (62%), Gaps = 13/297 (4%) Query: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVG 96 A ++ GR++A+ + E++ V+ +A+G RP L+V+LVG +PAS YV NK RAA VG Sbjct: 12 ARILDGRRIAEDLLDELKTRVDARLAAGQPRPGLAVVLVGGDPASTVYVRNKRRAAEKVG 71 Query: 97 INSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDG 156 I + PA E ELL+LI++LN D + G+LVQLPLP D R+ + + P KDVDG Sbjct: 72 IEAFDYDLPAGTGEAELLSLIDQLNADPKIHGILVQLPLPGIADASRLIHRIDPRKDVDG 131 Query: 157 FHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 216 FH NVG + L ++ + P TP G+ ++ T P G+N + G S +VG P+A+ L Sbjct: 132 FHPQNVGHLALREFGLRPCTPRGIVTLLAHTDQPVRGRNATIVGVSNHVGRPMALELLIA 191 Query: 217 GAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGI 276 G TV+ H++TP + L+ H ADI++ A G P LI D +K GA VIDVGI Sbjct: 192 G--------CTVSCCHKFTPADVLQTHVRDADILVVAVGRPGLIPGDWVKPGAVVIDVGI 243 Query: 277 NRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLR 333 NR+ D +LVGDV FE Q+A +ITPVPGGVGPMTVA LM+NTI AA LR Sbjct: 244 NRLDD-----GRLVGDVGFEAAAQRASWITPVPGGVGPMTVATLMQNTIEAADAALR 295 >3L07-A nrPDB Length = 285 Score = 375 bits (964), Expect = e-104, Method: Composition-based stats. Identities = 138/300 (46%), Positives = 186/300 (62%), Gaps = 17/300 (5%) Query: 35 NEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAV 94 N ++I G+ L++ +K+ + +V+E+ P L I+VG +PAS +YV +K +A A Sbjct: 2 NAMILIDGKSLSKDLKERLATQVQEYKHHTAITPKLVAIIVGNDPASKTYVASKEKACAQ 61 Query: 95 VGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDV 154 VGI+S+ I P +E ELL LI++LNND +V +LVQLPLP HI++ + ++ P+KDV Sbjct: 62 VGIDSQVITLPEHTTESELLELIDQLNNDSSVHAILVQLPLPAHINKNNVIYSIKPEKDV 121 Query: 155 DGFHVINVGRMCL-DQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLL 213 DGFH NVGR+ L D+ + TP G+ +++ GI T G VV G S VG P++ LL Sbjct: 122 DGFHPTNVGRLQLRDKKCLESCTPKGIMTMLREYGIKTEGAYAVVVGASNVVGKPVSQLL 181 Query: 214 HTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVID 273 ATVT HR+T LK HT ADI+I A G PN ITADM+KEGA VID Sbjct: 182 LNA--------KATVTTCHRFT--TDLKSHTTKADILIVAVGKPNFITADMVKEGAVVID 231 Query: 274 VGINRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLR 333 VGIN V K+VGDVDF V+ K ITPVPGGVGPMT+ L+ NT A+++ R Sbjct: 232 VGINHVD------GKIVGDVDFAAVKDKVAAITPVPGGVGPMTITELLYNTFQCAQELNR 285 >6DEB-A nrPDB Length = 285 Score = 375 bits (964), Expect = e-104, Method: Composition-based stats. Identities = 136/300 (45%), Positives = 192/300 (64%), Gaps = 17/300 (5%) Query: 35 NEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAV 94 N ++ G+ L+ +IK+E++++ +++ S L+VILVG+NPAS +YV +K +A Sbjct: 2 NAMTLLDGKALSAKIKEELKEK-NQFLKSKGIESCLAVILVGDNPASQTYVKSKAKACEE 60 Query: 95 VGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDV 154 GI S +I++ ELL LIN LN+DD+V G+LVQLPLP+HI + I ++ KDV Sbjct: 61 CGIKSLVYHLNENITQNELLALINTLNHDDSVHGILVQLPLPDHICKDLILESIISSKDV 120 Query: 155 DGFHVINVGRMCLD-QYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLL 213 DGFH INVG + L + LP TP GV +++K I GK+ V+ G S VG P+A +L Sbjct: 121 DGFHPINVGYLNLGLESGFLPCTPLGVMKLLKAYEIDLEGKDAVIIGASNIVGRPMATML 180 Query: 214 HTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVID 273 G ATV++ H T + L +T AD++I AAG NL+ +DM+KEG V+D Sbjct: 181 LNAG--------ATVSVCHIKT--KDLSLYTRQADLIIVAAGCVNLLRSDMVKEGVIVVD 230 Query: 274 VGINRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLR 333 VGINR+ K+VGDVDFE V +K+ YITPVPGGVGPMT+AML++NT+ +AK L Sbjct: 231 VGINRLES-----GKIVGDVDFEEVSKKSSYITPVPGGVGPMTIAMLLENTVKSAKNRLN 285 >4A26-A nrPDB Length = 300 Score = 375 bits (962), Expect = e-104, Method: Composition-based stats. Identities = 128/301 (42%), Positives = 172/301 (57%), Gaps = 12/301 (3%) Query: 36 EAVVISGRKLAQQIKQEVRQEVEEWVA-SGNKRPHLSVILVGENPASHSYVLNKTRAAAV 94 A +I G+ +A I+ E++ +V G + P L+ I+VG+ S YV K +AAA Sbjct: 5 SAQIIDGKAIAAAIRSELKDKVAALRELYGGRVPGLASIIVGQRMDSKKYVQLKHKAAAE 64 Query: 95 VGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDV 154 VG+ S + P IS+E L + KLNND N G++VQLPLP+H++E R + P KD Sbjct: 65 VGMASFNVELPEDISQEVLEVNVEKLNNDPNCHGIIVQLPLPKHLNENRAIEKIHPHKDA 124 Query: 155 DGFHVINVGRMCL--DQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAML 212 D +NVG + + P T GV ++KR GI GK VV GRS VG P+A L Sbjct: 125 DALLPVNVGLLHYKGREPPFTPCTAKGVIVLLKRCGIEMAGKRAVVLGRSNIVGAPVAAL 184 Query: 213 LHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVI 272 L + +ATVTI H T E + + ADIVI+A G P + + IKEGAAV+ Sbjct: 185 LMKE--------NATVTIVHSGTSTEDMIDYLRTADIVIAAMGQPGYVKGEWIKEGAAVV 236 Query: 273 DVGINRVHDPVTAKP-KLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKV 331 DVG V DP +LVGDV FE +A +I+PVPGGVGPMT+AML++NT+ A K Sbjct: 237 DVGTTPVPDPSRKDGYRLVGDVCFEEAAARAAWISPVPGGVGPMTIAMLLENTLEAFKAA 296 Query: 332 L 332 L Sbjct: 297 L 297 >6APE-A nrPDB Length = 298 Score = 367 bits (943), Expect = e-102, Method: Composition-based stats. Identities = 125/296 (42%), Positives = 190/296 (64%), Gaps = 15/296 (5%) Query: 38 VVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGI 97 V++ G+ LA I+++++ +++ +KRP L+VILVG++PAS +YV K +A VG+ Sbjct: 15 VLLDGQALAYSIEKDLKNKIQIITVQVHKRPKLAVILVGKDPASITYVNMKIKACERVGM 74 Query: 98 NSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGF 157 + + +++E ELL+LI N D N+ G+LVQLPLP HID + + A+ P KDVDGF Sbjct: 75 DFDLKTLQENVTEAELLSLIKDYNTDQNISGVLVQLPLPRHIDSKMVLEAIDPSKDVDGF 134 Query: 158 HVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDG 217 H +N+G++C + S LPATP GV ++K I GK+V + G S +G P++ML+ G Sbjct: 135 HPLNIGKLCTQKESFLPATPMGVMRLLKHYHIEIKGKDVAIIGASNIIGKPLSMLMLNAG 194 Query: 218 AHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGIN 277 A+V++ H T + + +T ADIV G P+LI A M+K+GA V+D+GIN Sbjct: 195 --------ASVSVCHILT--KDISFYTQNADIVCVGVGKPDLIKASMLKKGAVVVDIGIN 244 Query: 278 RVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLR 333 ++D ++VGDVDF ++ AG+ITPVP GVGPMT+ L++NT+IA +K R Sbjct: 245 HLND-----GRIVGDVDFTNAQKVAGFITPVPKGVGPMTIVSLLENTLIAFEKQQR 295 >4CJX-A nrPDB Length = 319 Score = 352 bits (904), Expect = 1e-97, Method: Composition-based stats. Identities = 123/302 (40%), Positives = 183/302 (60%), Gaps = 12/302 (3%) Query: 36 EAVVISGRKLAQQIKQEVRQEVEEW-VASGNKRPHLSVILVGENPASHSYVLNKTRAAAV 94 EAVVI GR +A+ I++E+ +EV +RP LS I+ G+ S +YV K +AAA Sbjct: 24 EAVVIDGRAVAKAIQKELTEEVALLERRYKGRRPGLSTIICGKRKDSQTYVRLKRKAAAA 83 Query: 95 VGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDV 154 G + ++ PA++++E L + +LN ++ ++VQLPLP HID+ + + P+KD Sbjct: 84 CGFRNFSVELPANVTQEALEREVIRLNEEEACHSIVVQLPLPPHIDKVAALSKIKPEKDA 143 Query: 155 DGFHVINVGRMCLDQ--YSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAML 212 D +NVG++ + + +++P T V E+++ +G+ GK VVV GR G+P+A L Sbjct: 144 DCLLPVNVGQLHIRERNPAIVPCTASAVMELLRCSGVEICGKRVVVLGRGDIAGLPVATL 203 Query: 213 LHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVI 272 L + DATVT+ H TP + +DIV+SAAG P L+ + IK GAAVI Sbjct: 204 LANE--------DATVTVVHSATPLCDIADIVRASDIVVSAAGQPGLVRGEWIKLGAAVI 255 Query: 273 DVGINRVHDPVTAKP-KLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKV 331 DVG V DP +LVGDV F+ R++A YITPVPGGVGP+TV+ML+KNT+ K+ Sbjct: 256 DVGTTPVADPSKVPGYRLVGDVCFDVARKRAAYITPVPGGVGPVTVSMLLKNTLTMFKRS 315 Query: 332 LR 333 +R Sbjct: 316 VR 317 >1DIA-A nrPDB Length = 306 Score = 348 bits (893), Expect = 2e-96, Method: Composition-based stats. Identities = 117/303 (38%), Positives = 174/303 (57%), Gaps = 16/303 (5%) Query: 37 AVVISGRKLAQQIKQEVRQEVEEWVAS-GNKRPHLSVILVGENPASHSYVLNKTRAAAVV 95 A +++G++++ QI+ ++ +V + P L+++ VG S+ Y+ K +AA + Sbjct: 4 AEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEI 63 Query: 96 GINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEH--IDERRICNAVSPDKD 153 GI + I P + +E E++ I LN D V G LVQLPL I+ + NA++P+KD Sbjct: 64 GIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPEKD 123 Query: 154 VDGFHVINVGRMCLDQY--SMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAM 211 VDG IN GR+ +P TP G E+IK TG+P G++ VV GRSK VG P+ Sbjct: 124 VDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHD 183 Query: 212 LLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAV 271 LL + +ATVT H T L + DI++ A G P ++ + IK GA V Sbjct: 184 LLLWN--------NATVTTCHSKTA--HLDEEVNKGDILVVATGQPEMVKGEWIKPGAIV 233 Query: 272 IDVGINRVHDPVTAKPK-LVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKK 330 ID GIN V D + +VGDV ++ +++A +ITPVPGGVGPMTVAMLM++T+ +AK+ Sbjct: 234 IDCGINYVPDDKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKR 293 Query: 331 VLR 333 L Sbjct: 294 FLE 296 >4B4V-A nrPDB Length = 303 Score = 345 bits (886), Expect = 1e-95, Method: Composition-based stats. Identities = 119/296 (40%), Positives = 168/296 (56%), Gaps = 16/296 (5%) Query: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVG 96 A+V+ GR LA+QI++ + VE A + P L+ ILVG++ AS +YV K A VG Sbjct: 23 ALVLDGRALAKQIEENLLVRVEALKAKTGRTPILATILVGDDGASATYVRMKGNACRRVG 82 Query: 97 INSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDG 156 ++S I P + E+LL I KLN + +V G+L+Q P+P IDER +A+S KDVDG Sbjct: 83 MDSLKIELPQETTTEQLLAEIEKLNANPDVHGILLQHPVPAQIDERACFDAISLAKDVDG 142 Query: 157 FHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 216 + GRM + + + ATP G+ I+K I GK+ VV GRS +G P+AM+L Sbjct: 143 VTCLGFGRMAMGEAAYGSATPAGIMTILKENNIEIAGKHAVVVGRSAILGKPMAMMLLQA 202 Query: 217 GAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGI 276 +ATVTI H T + L + ADI++ A G LI D IK+GA V+D G Sbjct: 203 --------NATVTICHSRT--QNLPELVKQADIIVGAVGKAELIQKDWIKQGAVVVDAGF 252 Query: 277 NRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVL 332 + VGD+ +G+ + A TPVPGGVGPMT+ L++ T+ AA+K L Sbjct: 253 HPRD------GGGVGDIQLQGIEEIASAYTPVPGGVGPMTITTLIRQTVEAAEKAL 302 >2C2Y-A nrPDB Length = 281 Score = 338 bits (866), Expect = 2e-93, Method: Composition-based stats. Identities = 120/295 (40%), Positives = 171/295 (57%), Gaps = 16/295 (5%) Query: 37 AVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVG 96 A+++ G+ +I +++Q V A+G + P L ILVG++P S +YV K A VG Sbjct: 3 AIMLDGKATRDEIFGDLKQRVAALDAAG-RTPGLGTILVGDDPGSQAYVRGKHADCAKVG 61 Query: 97 INSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDG 156 I S PA IS L I++LN + + G +VQLPLP+H+DE V P KD DG Sbjct: 62 ITSIRRDLPADISTATLNETIDELNANPDCTGYIVQLPLPKHLDENAALERVDPAKDADG 121 Query: 157 FHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTD 216 H N+GR+ L + LP TP G+ +++R I G +VVV GR VG P+ +LL Sbjct: 122 LHPTNLGRLVLGTPAPLPCTPRGIVHLLRRYDISIAGAHVVVIGRGVTVGRPLGLLL--- 178 Query: 217 GAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGI 276 R +ATVT+ H T L T ADIV++A G+ +L+TADM++ GAAVIDVG+ Sbjct: 179 ---TRRSENATVTLCH--TGTRDLPALTRQADIVVAAVGVAHLLTADMVRPGAAVIDVGV 233 Query: 277 NRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKV 331 +R D LVGDV + V + AG+++P PGGVGP+T A L+ N + A++ Sbjct: 234 SRTDD------GLVGDVHPD-VWELAGHVSPNPGGVGPLTRAFLLTNVVELAERR 281 >3NGX-A nrPDB Length = 276 Score = 303 bits (775), Expect = 9e-83, Method: Composition-based stats. Identities = 89/284 (31%), Positives = 147/284 (51%), Gaps = 19/284 (6%) Query: 46 AQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAAAVVGINSETIMKP 105 ++I ++ + + + P L +I +G+N A+ Y K R +GI + + K Sbjct: 6 GEEIAEKKAENLHGIIERSGLEPSLKLIQIGDNEAASIYARAKIRRGKKIGIAVD-LEKY 64 Query: 106 ASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVDGFHVINVGRM 165 IS ++LL I+ L D ++G++++ PLP+ D I + KDVD N G + Sbjct: 65 DDISMKDLLKRIDDLAKDPQINGIMIENPLPKGFDYYEIVRNIPYYKDVDALSPYNQGLI 124 Query: 166 CLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGD 225 L++ ++PATP V +I+ G V + RS VG P++M+L + Sbjct: 125 ALNREFLVPATPRAVIDIMDYYGYHE--NTVTIVNRSPVVGRPLSMMLLNR--------N 174 Query: 226 ATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTA 285 TV++ H T + + T + IV+ A G P + +M+ G+ VIDVGIN V+D Sbjct: 175 YTVSVCHSKT--KDIGSMTRSSKIVVVAVGRPGFLNREMVTPGSVVIDVGINYVND---- 228 Query: 286 KPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAK 329 K+VGD +FE + + ITPVPGGVGP+T +++N + AA+ Sbjct: 229 --KVVGDANFEDLSEYVEAITPVPGGVGPITATNILENVVKAAE 270 >1EDZ-A nrPDB Length = 320 Score = 260 bits (665), Expect = 6e-70, Method: Composition-based stats. Identities = 79/336 (23%), Positives = 141/336 (41%), Gaps = 57/336 (16%) Query: 38 VVISGRKLAQQIKQEVRQEVEEWVASGNKR-PHLSVILVGENPASHSYVLNKTRAAAVVG 96 I K+A+ E+ VEE+ + N + P L L +PA+ Y + + +G Sbjct: 6 RTILASKVAETFNTEIINNVEEYKKTHNGQGPLLVGFLANNDPAAKMYATWTQKTSESMG 65 Query: 97 INSET-IMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAVSPDKDVD 155 + +++ EE I + N DD+V+G++V P+ + ++ + V +KDV+ Sbjct: 66 FRYDLRVIEDKDFLEEA----IIQANGDDSVNGIMVYFPVFGNAQDQYLQQVVCKEKDVE 121 Query: 156 GFHVINVGRMCL---------DQYSMLPATPWGVWEIIKRTGIPT---------LGKNVV 197 G + + + S+LP TP + +I++ I GK + Sbjct: 122 GLNHVYYQNLYHNVRYLDKENRLKSILPCTPLAIVKILEFLKIYNNLLPEGNRLYGKKCI 181 Query: 198 VAGRSKNVGMPIAMLLHTDGA----------HERPGGDATVTISHRYT-----PKEQLKK 242 V RS+ VG P+A LL DGA + G++ H ++ LKK Sbjct: 182 VINRSEIVGRPLAALLANDGATVYSVDVNNIQKFTRGESLKLNKHHVEDLGEYSEDLLKK 241 Query: 243 HTILADIVISAAGIPNL-ITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQK 301 ++ +D+VI+ N + IKEGA I+ + + V++K Sbjct: 242 CSLDSDVVITGVPSENYKFPTEYIKEGAVCINFACTKNFS--------------DDVKEK 287 Query: 302 AGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLEER 337 A P+ G V T+AML++N + + V +E+ Sbjct: 288 ASLYVPMTGKV---TIAMLLRNMLRLVRNVELSKEK 320 >6GBN-A nrPDB Length = 438 Score = 39.6 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 27/107 (25%), Positives = 41/107 (38%), Gaps = 7/107 (6%) Query: 175 ATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAH---ERPGGDATVTIS 231 V I + T + GK VVAG VG A L GA + + Sbjct: 201 CKESLVDSIRRATDVMMAGKVAVVAGYGD-VGKGSAASLRGAGARVIVTEIDPICALQAA 259 Query: 232 HRYTPKEQLKKHTILADIVISAAGIPNLITADMIK---EGAAVIDVG 275 +++ ADIV++A G N+IT + K + V ++G Sbjct: 260 MDGYEVKKMADAVKRADIVVTATGNKNIITGEHFKAMRDKVIVCNIG 306 >2EEZ-A nrPDB Length = 369 Score = 39.3 bits (90), Expect = 0.003, Method: Composition-based stats. Identities = 32/120 (26%), Positives = 54/120 (45%), Gaps = 16/120 (13%) Query: 237 KEQLKKHTILADIVISAAGIPN-----LITADMI---KEGAAVIDVGINRVHDPVTAKPK 288 + +KK AD++I A +P L+T DM+ KEGA ++DV +++ T +P Sbjct: 220 EANIKKSVQHADLLIGAVLVPGAKAPKLVTRDMLSLMKEGAVIVDVAVDQGGCVETIRPT 279 Query: 289 LVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKN-----TIIAAKKVLR--LEEREVLK 341 + + + +PG V P T + N + A+K L LE+ +LK Sbjct: 280 THAEPTYVVDGVVHYGVANMPGAV-PRTSTFALTNQTLPYVLKLAEKGLDALLEDAALLK 338 >6APH-A nrPDB Length = 445 Score = 37.7 bits (86), Expect = 0.007, Method: Composition-based stats. Identities = 23/107 (21%), Positives = 38/107 (35%), Gaps = 7/107 (6%) Query: 175 ATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGA---HERPGGDATVTIS 231 V I + T + GK VVV G VG A G+ + + Sbjct: 208 CRESAVDAIRRATDVMLAGKRVVVCGFGD-VGKGTAASFRGAGSIVTVTEIDPICALQAA 266 Query: 232 HRYTPKEQLKKHTILADIVISAAGIPNLITADM---IKEGAAVIDVG 275 +QL ADI+I+ G ++ + +K+ V ++G Sbjct: 267 MEGYEVKQLDTVVDNADIIITTTGNFGIVRGEHFEKMKDKTIVCNIG 313 >3OND-A nrPDB Length = 488 Score = 37.7 bits (86), Expect = 0.007, Method: Composition-based stats. Identities = 24/99 (24%), Positives = 39/99 (39%), Gaps = 7/99 (7%) Query: 183 IIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAH---ERPGGDATVTISHRYTPKEQ 239 +++ T + GK VVAG VG A L GA + + Sbjct: 255 LMRATDVMIAGKVAVVAGYGD-VGKGCAAALKQAGARVIVTEIDPICALQATMEGLQVLT 313 Query: 240 LKKHTILADIVISAAGIPNLITADMIKE---GAAVIDVG 275 L+ ADI ++ G ++I D +K+ A V ++G Sbjct: 314 LEDVVSEADIFVTTTGNKDIIMLDHMKKMKNNAIVCNIG 352 >4WLE-A nrPDB Length = 340 Score = 35.8 bits (81), Expect = 0.027, Method: Composition-based stats. Identities = 21/97 (21%), Positives = 31/97 (31%), Gaps = 18/97 (18%) Query: 194 KNVVVAGRSKNVGMPIAMLLHTD---------------GAHERPGGDATVTISHRYTPKE 238 V V G S +G P+++LL G T Y E Sbjct: 27 AKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETKAAVKGYLGPE 86 Query: 239 QLKKHTILADIVISAAG---IPNLITADMIKEGAAVI 272 QL D+V+ AG P + D+ A ++ Sbjct: 87 QLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIV 123 >2DZD-A nrPDB Length = 461 Score = 35.8 bits (81), Expect = 0.031, Method: Composition-based stats. Identities = 23/124 (18%), Positives = 42/124 (33%), Gaps = 15/124 (12%) Query: 90 RAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVDGLLV---QLPLPEHIDERRICN 146 RA +GI + I + ++ D+ LV + P+ ++D I Sbjct: 23 RACTELGIRTVAIYSKEDVGS------YHRYKADEA---YLVGEGKKPIEAYLDIEGIIE 73 Query: 147 AVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGVWEI-IKRTGIPTLGKNVVVAGRSKNV 205 ++ DVD H G + + G+ I + G V + N Sbjct: 74 -IAKAHDVDAIHP-GYGFLSENIQFAKRCREEGIIFIGPNENHLDMFGDKVKARHAAVNA 131 Query: 206 GMPI 209 G+P+ Sbjct: 132 GIPV 135 >1MLD-A nrPDB Length = 314 Score = 35.8 bits (81), Expect = 0.031, Method: Composition-based stats. Identities = 21/97 (21%), Positives = 31/97 (31%), Gaps = 18/97 (18%) Query: 194 KNVVVAGRSKNVGMPIAMLLHTD---------------GAHERPGGDATVTISHRYTPKE 238 V V G S +G P+++LL G T Y E Sbjct: 1 AKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETRATVKGYLGPE 60 Query: 239 QLKKHTILADIVISAAG---IPNLITADMIKEGAAVI 272 QL D+V+ AG P + D+ A ++ Sbjct: 61 QLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIV 97 >4WJI-A nrPDB Length = 293 Score = 35.4 bits (80), Expect = 0.040, Method: Composition-based stats. Identities = 17/60 (28%), Positives = 26/60 (43%), Gaps = 5/60 (8%) Query: 241 KKHTILADIVISAA--GIPNLITADM---IKEGAAVIDVGINRVHDPVTAKPKLVGDVDF 295 + AD+V+ + G + A++ +K GA V DVG + P L DV F Sbjct: 59 AEAVEGADLVVVSVPVGASGAVAAEIAAHLKPGAIVTDVGSTKGSVIAQMAPHLPKDVHF 118 >2VHY-A nrPDB Length = 377 Score = 34.2 bits (77), Expect = 0.083, Method: Composition-based stats. Identities = 22/101 (21%), Positives = 40/101 (39%), Gaps = 18/101 (17%) Query: 194 KNVVVAGRS----------KNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKH 243 +VVV G +G + +L + + I RY+ +L+ Sbjct: 169 ADVVVIGAGTAGYNAARIANGMGATVTVLDINIDKLRQLDAEFCGRIHTRYSSAYELEGA 228 Query: 244 TILADIVISAAGIPN-----LITADMI---KEGAAVIDVGI 276 AD+VI A +P L++ ++ K GA ++D+ I Sbjct: 229 VKRADLVIGAVLVPGAKAPKLVSNSLVAHMKPGAVLVDIAI 269 >5JXW-A nrPDB Length = 498 Score = 33.9 bits (76), Expect = 0.099, Method: Composition-based stats. Identities = 26/103 (25%), Positives = 39/103 (37%), Gaps = 9/103 (8%) Query: 191 TLGKNVVVAGRSKNVGMPIAMLLHTDGAH---ERPGGDATVTISHRYTPKEQLKKHTILA 247 GK +VV G + VG A L GA + S L+ A Sbjct: 269 LAGKKIVVLGYGE-VGKGCAQGLSGVGARVIVTEIDPICALQASMEGYQVSVLEDVVSEA 327 Query: 248 DIVISAAGIPNLITADM---IKEGAAVIDVGINRVHDPVTAKP 287 DI I+A G ++IT + +KE A + ++G D + Sbjct: 328 DIFITATGNKDVITVEHMRKMKENAYIANIG--HFDDEIDVYG 368 >4DIO-A nrPDB Length = 405 Score = 33.5 bits (75), Expect = 0.13, Method: Composition-based stats. Identities = 30/118 (25%), Positives = 49/118 (41%), Gaps = 12/118 (10%) Query: 240 LKKHTILADIVISAA-----GIPNLITADMI---KEGAAVIDVGINR---VHDPVTAKPK 288 + +H DIVI+ A P L+T +M+ K G+ V+D+ + R + K Sbjct: 269 VAEHIAKQDIVITTALIPGRPAPRLVTREMLDSMKPGSVVVDLAVERGGNIEGAEAGKVT 328 Query: 289 LVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLRLE-EREVLKSKEL 345 VG V G AG I + + ++ + K L L E E++K+ L Sbjct: 329 EVGGVRIVGHLNVAGRIAASASLLYAKNLVTFLETMVSKETKALALNMEDELVKATAL 386 >3X2F-A nrPDB Length = 411 Score = 33.1 bits (74), Expect = 0.17, Method: Composition-based stats. Identities = 31/100 (31%), Positives = 49/100 (49%), Gaps = 9/100 (9%) Query: 183 IIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAH----ERPGGDATVTISHRYTPKE 238 I++ T + GKNVVVAG G IA+ GA E A I +T Sbjct: 187 IMRNTNLLVAGKNVVVAGYG-WCGRGIALRAAGLGARVIVTEVDPVKAVEAIMDGFTVMP 245 Query: 239 QLKKHTILADIVISAAGIPNLITADMI---KEGAAVIDVG 275 +K+ +AD VI+A+G ++++ + I K+GA + + G Sbjct: 246 -MKEAVKIADFVITASGNTDVLSKEDILSLKDGAVLANAG 284 >2RIR-A nrPDB Length = 300 Score = 33.1 bits (74), Expect = 0.18, Method: Composition-based stats. Identities = 33/171 (19%), Positives = 61/171 (35%), Gaps = 16/171 (9%) Query: 173 LPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISH 232 +P + I+ T G V V G + GM IA GA+ + G ++ ++ Sbjct: 137 IPTVEGTIMLAIQHTDYTIHGSQVAVLGLGRT-GMTIARTFAALGANVKVGARSSAHLAR 195 Query: 233 RYT------PKEQLKKHTILADIVISAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAK 286 ++LK+H DI I N I + ++ + + D + Sbjct: 196 ITEMGLVPFHTDELKEHVKDIDICI------NTIPSMILNQTVLSSMTPKTLILDLASRP 249 Query: 287 PKLVGDVDFEGVRQKAGYITP-VPGGVGPMTVAMLMKNTIIAAKKVLRLEE 336 D + + + P +PG V P T ++ N + ++ EE Sbjct: 250 GGT--DFKYAEKQGIKALLAPGLPGIVAPKTAGQILANVLSKLLAEIQAEE 298 >5UXF-A nrPDB Length = 342 Score = 32.7 bits (73), Expect = 0.24, Method: Composition-based stats. Identities = 14/75 (18%), Positives = 28/75 (37%), Gaps = 3/75 (4%) Query: 199 AGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPN 258 G S + +L+ G +P + H Y + +L + DIV+ A G Sbjct: 182 IGVSNFNHRQLERILNKPGLKYKPVCNQVE--CHLYLNQRKLLDYCESKDIVLVAYGALG 239 Query: 259 LIT-ADMIKEGAAVI 272 + + + + V+ Sbjct: 240 TQRYKEWVDQNSPVL 254 >1PJB-A nrPDB Length = 361 Score = 32.3 bits (72), Expect = 0.31, Method: Composition-based stats. Identities = 26/127 (20%), Positives = 53/127 (41%), Gaps = 14/127 (11%) Query: 234 YTPKEQLKKHTILADIVISAAGIPN-----LITADMIKE---GAAVIDVGINRVHDPVTA 285 Y+ +++ AD++I A +P L+ A ++++ G+ ++DV +++ T Sbjct: 218 YSNSAEIETAVAEADLLIGAVLVPGRRAPILVPASLVEQMRTGSVIVDVAVDQGGCVETL 277 Query: 286 KPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKN-----TIIAAKKVLRLEEREVL 340 P +E + +PG V P T + N + A + L+ E + Sbjct: 278 HPTSHTQPTYEVFGVVHYGVPNMPGAV-PWTATQALNNSTLPYVVKLANQGLKALETDDA 336 Query: 341 KSKELGV 347 +K L V Sbjct: 337 LAKGLNV 343 >1SMK-A nrPDB Length = 326 Score = 31.9 bits (71), Expect = 0.39, Method: Composition-based stats. Identities = 25/98 (25%), Positives = 40/98 (40%), Gaps = 18/98 (18%) Query: 193 GKNVVVAGRSKNVGMPIAMLL----HTDGAHERPGGDA---TVTISHRYT--------PK 237 G V + G + +G P+AML+ H +A T ISH T + Sbjct: 8 GFKVAILGAAGGIGQPLAMLMKMNPLVSVLHLYDVVNAPGVTADISHMDTGAVVRGFLGQ 67 Query: 238 EQLKKHTILADIVISAAG---IPNLITADMIKEGAAVI 272 +QL+ D++I AG P + D+ K A ++ Sbjct: 68 QQLEAALTGMDLIIVPAGVPRKPGMTRDDLFKINAGIV 105 >2ZOY-A nrPDB Length = 185 Score = 31.6 bits (70), Expect = 0.58, Method: Composition-based stats. Identities = 17/77 (22%), Positives = 29/77 (37%), Gaps = 2/77 (2%) Query: 190 PTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTP-KEQLKKHTILAD 248 P VV ++NV P +LL D +A T++H++ P + L+ Sbjct: 77 PLERLRAVVVTLAENVSRP-ELLLLIDAPSHPDFLNAWRTVNHQWIPDTDDLENDAHKRA 135 Query: 249 IVISAAGIPNLITADMI 265 + + L D I Sbjct: 136 VYLVQLAADGLFVHDYI 152 >3KC2-A nrPDB Length = 352 Score = 31.6 bits (70), Expect = 0.59, Method: Composition-based stats. Identities = 15/47 (31%), Positives = 27/47 (57%), Gaps = 1/47 (2%) Query: 38 VVIS-GRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHS 83 V+I ++L+ +I Q V+Q++ + P +V +VG+NPAS Sbjct: 258 VLIDWEKRLSGKIGQSVKQKLPLLGTKPSTSPFHAVFMVGDNPASDI 304 >2HE8-A nrPDB Length = 323 Score = 31.6 bits (70), Expect = 0.61, Method: Composition-based stats. Identities = 15/75 (20%), Positives = 28/75 (37%), Gaps = 3/75 (4%) Query: 199 AGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPN 258 G S + M+L+ G +P + H Y + +L DIV+ A G+ Sbjct: 163 IGVSNFNYRQLEMILNKPGLKYKPVCNQVE--CHPYLNQMKLLDFCKSKDIVLVAYGVLG 220 Query: 259 LIT-ADMIKEGAAVI 272 + + + V+ Sbjct: 221 TQRYGGWVDQNSPVL 235 >3F9I-A nrPDB Length = 249 Score = 31.6 bits (70), Expect = 0.61, Method: Composition-based stats. Identities = 21/84 (25%), Positives = 32/84 (38%), Gaps = 17/84 (20%) Query: 189 IPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGG---------------DATVTISHR 233 I GK ++ G S +G IA LLH G+ G + T+ + + Sbjct: 10 IDLTGKTSLITGASSGIGSAIARLLHKLGSKVIISGSNEEKLKSLGNALKDNYTIEVCNL 69 Query: 234 YTPKE--QLKKHTILADIVISAAG 255 +E L T DI++ AG Sbjct: 70 ANKEECSNLISKTSNLDILVCNAG 93 >4JQA-A nrPDB Length = 331 Score = 31.2 bits (69), Expect = 0.81, Method: Composition-based stats. Identities = 14/75 (18%), Positives = 26/75 (34%), Gaps = 3/75 (4%) Query: 199 AGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPN 258 G S + M+L+ G +P + H Y + +L DIV+ A Sbjct: 163 IGVSNFNHRLLEMILNKPGLKYKPVCNQVE--CHPYFNQRKLLDFCKSKDIVLVAYSALG 220 Query: 259 LITAD-MIKEGAAVI 272 + + + V+ Sbjct: 221 SHREEPWVDPNSPVL 235 >5JM5-A nrPDB Length = 332 Score = 30.4 bits (67), Expect = 1.1, Method: Composition-based stats. Identities = 19/99 (19%), Positives = 31/99 (31%), Gaps = 9/99 (9%) Query: 175 ATPWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRY 234 T W E K G+ G S + M+L+ G +P + H Y Sbjct: 145 CTTWEAMEKCKDAGL------AKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVE--CHPY 196 Query: 235 TPKEQLKKHTILADIVISAAGIPNLIT-ADMIKEGAAVI 272 + +L DIV+ A + + V+ Sbjct: 197 FNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVL 235 >3RAC-A nrPDB Length = 373 Score = 30.0 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 22/129 (17%), Positives = 46/129 (35%), Gaps = 13/129 (10%) Query: 25 LRPFHLAAVRNEAVVISGRKLAQQIKQEV---RQEVEEWVASGNKRP-----HLSVILVG 76 LR + R+ + G A ++ E+ + + + P V Sbjct: 71 LRARSPESSRDWIRLFDGGGDAVALRPEMTPSIARMAAPRVAAGRTPIRWCYCERVYRRT 130 Query: 77 ENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNV--DGLLVQLP 134 ++PAS S+ K + VGI + ++L L+++ + V ++V Sbjct: 131 DDPASLSWASGKAAESTQVGIERIGEEASVDVDM-DVLRLLHEASAAAGVRHHRIVVSHA 189 Query: 135 --LPEHIDE 141 +P +D Sbjct: 190 RLVPRLLDA 198 >6D4C-A nrPDB Length = 364 Score = 30.0 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 27/119 (22%), Positives = 49/119 (41%), Gaps = 16/119 (13%) Query: 223 GGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMIKEG-----AAVIDVGIN 277 G +T S + L +H ADI+I+ P IT + I + V VG + Sbjct: 37 QGHELITTSDKEGGNSVLDQHIPDADIIITTPFHPAYITKERIDKAKKLKLVVVAGVGSD 96 Query: 278 RVH-DPVTAKPK--LVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLMKNTIIAAKKVLR 333 + D + K V +V V A ++ MT+ +L++N + A ++++ Sbjct: 97 HIDLDYINQTGKKISVLEVTGSNVVSGAEHVL--------MTMLVLVRNFVPAHEQIIN 147 >3D64-A nrPDB Length = 494 Score = 30.0 bits (66), Expect = 1.7, Method: Composition-based stats. Identities = 25/99 (25%), Positives = 38/99 (38%), Gaps = 7/99 (7%) Query: 183 IIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAH---ERPGGDATVTISHRYTPKEQ 239 I + T + GK VVAG VG A L GA + + Sbjct: 267 IKRATDVMIAGKIAVVAGYGD-VGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVT 325 Query: 240 LKKHTILADIVISAAGIPNLITADMIK---EGAAVIDVG 275 ++ ADI ++A G ++I D +K A V ++G Sbjct: 326 MEYAADKADIFVTATGNYHVINHDHMKAMRHNAIVCNIG 364 >5CEE-A nrPDB Length = 413 Score = 29.6 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 24/106 (22%), Positives = 38/106 (35%), Gaps = 19/106 (17%) Query: 177 PWGVWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDAT--------- 227 G+ +K VV+ G GM IA +L + D T Sbjct: 191 AAGILNALKVVKKSIEDVQVVINGAGS-AGMAIAKMLLLLKVNNVVLVDKTGTLYKGVAN 249 Query: 228 --------VTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMI 265 V ++++Y K LK+ DI I P ++TA+M+ Sbjct: 250 LNEPQKKLVEVTNKYQEKGTLKEVLKGKDIFI-GVSAPGIVTAEMV 294 >4UR8-A nrPDB Length = 311 Score = 29.6 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 19/85 (22%), Positives = 34/85 (40%), Gaps = 4/85 (4%) Query: 33 VRNEAVVISGRKLAQQIKQEVRQEVEEWVASGNKRPHLSVILVGENPASHSYVLNKTRAA 92 V E ++SG +I ++ + VE+ A G L L+ + P Y K + Sbjct: 75 VAGETAIVSGCGYGTEIAVDIARSVEKVGADGIL--LLPHYLI-DAPQEGLYAHIK-KVC 130 Query: 93 AVVGINSETIMKPASISEEELLNLI 117 VGI + S+ + + L + Sbjct: 131 QSVGIGVMVYNRDNSVLQADTLARL 155 >4BVA-A nrPDB Length = 335 Score = 29.6 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 12/64 (18%), Positives = 26/64 (40%), Gaps = 1/64 (1%) Query: 240 LKKHTILADIVI-SAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGV 298 +++ AD++I ++ + +K GA + VG +R + V + Sbjct: 212 VQEAVTGADVIITVTMATEPILFGEWVKPGAHINAVGASRPDWRELDDELMRQAVLYVDS 271 Query: 299 RQKA 302 R+ A Sbjct: 272 REAA 275 >2D0I-A nrPDB Length = 333 Score = 29.6 bits (65), Expect = 2.0, Method: Composition-based stats. Identities = 19/94 (20%), Positives = 33/94 (35%), Gaps = 9/94 (9%) Query: 190 PTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKE--QLKKHTILA 247 GK V + G G IA L G + + + + Sbjct: 143 SLYGKKVGILGMGAI-GKAIARRLIPFGVKLYYWSRHRKVNVEKELKARYMDIDELLEKS 201 Query: 248 DIVISAAGIP----NLITADMIK--EGAAVIDVG 275 DIVI A + ++I + +K EG ++++G Sbjct: 202 DIVILALPLTRDTYHIINEERVKKLEGKYLVNIG 235 >3K8Z-A nrPDB Length = 423 Score = 29.2 bits (64), Expect = 2.4, Method: Composition-based stats. Identities = 20/57 (35%), Positives = 22/57 (38%), Gaps = 5/57 (8%) Query: 174 PATPWGVWEIIKRT----GIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDA 226 AT GV IK GI G VVV G G +A +H GA DA Sbjct: 197 SATAKGVTICIKEAAKKRGIDIKGARVVVQGFGN-AGSYLAKFMHDAGAKVVGISDA 252 >5KKP-A nrPDB Length = 563 Score = 29.2 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 22/99 (22%), Positives = 40/99 (40%), Gaps = 19/99 (19%) Query: 262 ADMIKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQKAGYITPVPGGVGPMTVAMLM 321 ADM+K G DVGI + ++ + + ++ G G ++ + Sbjct: 4 ADMMKHGLTEADVGITKFVSSHQGFSGILK-------ERYSDFVVHEIGKDGRISHLNDL 56 Query: 322 K------------NTIIAAKKVLRLEEREVLKSKELGVA 348 T++ A++ RLEE ++ K+KE VA Sbjct: 57 SIPVDEEDPSEDIFTVLTAEEKQRLEELQLFKNKETSVA 95 >2FVL-A nrPDB Length = 324 Score = 29.2 bits (64), Expect = 3.0, Method: Composition-based stats. Identities = 13/55 (23%), Positives = 21/55 (38%), Gaps = 2/55 (3%) Query: 199 AGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISA 253 G S + M+L+ G +P + H Y + +L DIV+ A Sbjct: 164 IGVSNFNYRQLEMILNKPGLKYKPVCNQVE--CHPYLNQSKLLDFCKSKDIVLVA 216 >5KS8-A nrPDB Length = 405 Score = 28.9 bits (63), Expect = 3.1, Method: Composition-based stats. Identities = 20/129 (15%), Positives = 40/129 (31%), Gaps = 22/129 (17%) Query: 89 TRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVDGLLVQLPLPEHIDERRICNAV 148 RA + +GI S I A + N + P+ +++ I N + Sbjct: 18 VRACSEMGIKSVAIYSDADRHALHVKKADEAYNIGSD--------PVLGYLNAHNIVN-L 68 Query: 149 SPDKDVDGFHVINVGRMCLDQYSMLPATPWGV------WEIIKRTGIPTLGKNVVV---- 198 + D H G + + G+ ++I++ G + ++ Sbjct: 69 AVASGCDALHP-GYGFLSENPELAEICARRGIKFIGPDAKVIRQMGDKIQARTAMIKAGI 127 Query: 199 --AGRSKNV 205 G S V Sbjct: 128 PCVGSSGVV 136 >3G1R-A nrPDB Length = 346 Score = 28.9 bits (63), Expect = 3.7, Method: Composition-based stats. Identities = 20/108 (18%), Positives = 40/108 (37%), Gaps = 18/108 (16%) Query: 146 NAVSPDKDVDGFHVINVGRMCLDQYSMLPATPWGVWEIIKRTGIPTLGKNVVVAGRSKNV 205 + + P +D +G + + +C +M G+ + + G S Sbjct: 149 DEIYP-RDENGKWLYHKSNLCATWEAMEACKDAGLVKSL---------------GVSNFN 192 Query: 206 GMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISA 253 + ++L+ G +P + H Y + +L K DIVI+A Sbjct: 193 RRQLELILNKPGLKHKPVSNQVE--CHPYFTQPKLLKFCQQHDIVITA 238 >1O5I-A nrPDB Length = 249 Score = 28.9 bits (63), Expect = 3.8, Method: Composition-based stats. Identities = 15/77 (19%), Positives = 26/77 (33%), Gaps = 9/77 (11%) Query: 191 TLGKNVVVAGRSKNVGMPIAMLLHTDGAHER---------PGGDATVTISHRYTPKEQLK 241 K V+V S+ +G +A +L +GA + + L Sbjct: 17 IRDKGVLVLAASRGIGRAVADVLSQEGAEVTICARNEELLKRSGHRYVVCDLRKDLDLLF 76 Query: 242 KHTILADIVISAAGIPN 258 + DI++ AG P Sbjct: 77 EKVKEVDILVLNAGGPK 93 >5OVL-A nrPDB Length = 300 Score = 28.5 bits (62), Expect = 4.1, Method: Composition-based stats. Identities = 17/71 (23%), Positives = 25/71 (35%), Gaps = 9/71 (12%) Query: 250 VISAAGIPNLITADM-------IKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQKA 302 V + P I +M I+ GA +D + V + E A Sbjct: 229 VTANVVAPGYIDTEMTRALDERIQAGA--LDFIPAKRVGTAEEVAGAVSFLASEDASYIA 286 Query: 303 GYITPVPGGVG 313 G + PV GG+G Sbjct: 287 GAVIPVDGGMG 297 >3KXP-A nrPDB Length = 314 Score = 28.5 bits (62), Expect = 4.6, Method: Composition-based stats. Identities = 24/132 (18%), Positives = 45/132 (34%), Gaps = 6/132 (4%) Query: 216 DGAHERPGGDATVTISHRYTPKEQLKKHTILADIV--ISAAGIPNLITADMIKEGAAVID 273 G + + H + + D+V + A I + + A ++ Sbjct: 125 AGLIRTLARGHAILVGHSLGARNSVTAAAKYPDLVRSVVAIDFTPYIETEALDALEARVN 184 Query: 274 VGINRVHDPVTAKPKLVG---DVDFEGVRQKA-GYITPVPGGVGPMTVAMLMKNTIIAAK 329 G D + L G ++ + +R +A PV GG+ P+ + M T + Sbjct: 185 AGSQLFEDIKAVEAYLAGRYPNIPADAIRIRAESGYQPVDGGLRPLASSAAMAQTARGLR 244 Query: 330 KVLRLEEREVLK 341 L R+V K Sbjct: 245 SDLVPAYRDVTK 256 >4JA0-A nrPDB Length = 425 Score = 28.5 bits (62), Expect = 4.6, Method: Composition-based stats. Identities = 13/70 (18%), Positives = 32/70 (45%), Gaps = 3/70 (4%) Query: 71 SVILVGENPASHSYVLNKTRAAAVVGINSETIMKPASISEEELLNLINKLNNDDNVDGLL 130 V++ +PA + +AA +G++ + + A + EE L ++ + ++ G L Sbjct: 268 KVVVFMGSPADQEHCQKIAKAARELGLDVDLRVTSAHKATEETLRIMQQY---EDTHGAL 324 Query: 131 VQLPLPEHID 140 V + + + Sbjct: 325 VFIAVAGRSN 334 >1NHQ-A nrPDB Length = 447 Score = 28.5 bits (62), Expect = 4.7, Method: Composition-based stats. Identities = 20/88 (22%), Positives = 30/88 (34%), Gaps = 19/88 (21%) Query: 192 LGKNVVVAGRSKNVGMPIAMLL-------HTDGAHERPGGDATVTISHRYTPKEQLKKHT 244 GK V V + P+ + L T+ AT RY +++K Sbjct: 171 AGKKVTVI---DILDRPLGVYLDKEFTDVLTEEMEANNITIATGETVERYEGDGRVQKVV 227 Query: 245 IL-----ADIVISAAG-IPNLITADMIK 266 AD+V+ A G PN +K Sbjct: 228 TDKNAYDADLVVVAVGVRPN---TAWLK 252 >5M65-A nrPDB Length = 479 Score = 28.5 bits (62), Expect = 4.8, Method: Composition-based stats. Identities = 23/99 (23%), Positives = 39/99 (39%), Gaps = 7/99 (7%) Query: 183 IIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGD---ATVTISHRYTPKEQ 239 I + T + GK +VAG VG A L G + + Sbjct: 250 IRRGTDVMLSGKVAMVAGFGD-VGKGSAASLRQAGCRVMVSEVDPICALQAAMEGYEVVT 308 Query: 240 LKKHTILADIVISAAGIPNLITADM---IKEGAAVIDVG 275 ++ ADI ++A G ++IT + +K+ A V ++G Sbjct: 309 MEDAAPRADIFVTATGNKDIITIEHMRAMKDRAIVCNIG 347 >4PPM-A nrPDB Length = 861 Score = 28.5 bits (62), Expect = 4.8, Method: Composition-based stats. Identities = 30/157 (19%), Positives = 52/157 (33%), Gaps = 25/157 (15%) Query: 156 GFHVINVGRM--CLDQYSMLPATP----------WGVWEIIKRTGIPTLGKNVVVAGRSK 203 GF I VGR + S +P T + +I I + V + G Sbjct: 106 GFTSI-VGRRGEATAEKSPVPVTSGNSLTTYAGYKALMQIQSWLEIRPEEEPVAIVGYPG 164 Query: 204 NVGMPIAMLLHTDG-----AHERPGGDATVTISH-------RYTPKEQLKKHTILADIVI 251 ++ + ++ LL G H D + +SH R T + + Sbjct: 165 SICLALSRLLLAHGFSLHLLHRAGNHDRSELLSHLPEEYHSRVTLTSDPEDLYPRCKLFA 224 Query: 252 SAAGIPNLITADMIKEGAAVIDVGINRVHDPVTAKPK 288 +A +I ++ G+ IDV + R T + Sbjct: 225 AATSAGGVIDPARLQPGSIFIDVALPRDIASETRPAR 261 >5OVJ-A nrPDB Length = 256 Score = 28.5 bits (62), Expect = 5.2, Method: Composition-based stats. Identities = 17/71 (23%), Positives = 25/71 (35%), Gaps = 9/71 (12%) Query: 250 VISAAGIPNLITADM-------IKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQKA 302 V + P I +M I+ GA +D + V + E A Sbjct: 185 VTANVVAPGYIDTEMTRALDERIQAGA--LDFIPAKRVGTAEEVAGAVSFLASEDASYIA 242 Query: 303 GYITPVPGGVG 313 G + PV GG+G Sbjct: 243 GAVIPVDGGMG 253 >3RX4-A nrPDB Length = 336 Score = 28.1 bits (61), Expect = 5.5, Method: Composition-based stats. Identities = 14/69 (20%), Positives = 26/69 (37%), Gaps = 2/69 (2%) Query: 199 AGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPN 258 G S + + M+L+ G +P + H Y +E+L ++ IV++A Sbjct: 177 IGISNFNHLQVEMILNKPGLKYKPAVNQIE--CHPYLTQEKLIQYCQSKGIVVTAYSPLG 234 Query: 259 LITADMIKE 267 K Sbjct: 235 SPDRPWAKP 243 >2X9N-A nrPDB Length = 288 Score = 27.7 bits (60), Expect = 8.1, Method: Composition-based stats. Identities = 16/66 (24%), Positives = 25/66 (37%), Gaps = 4/66 (6%) Query: 188 GIPTLGKNVVVAGRSKNVGMPIAMLLHTDGA----HERPGGDATVTISHRYTPKEQLKKH 243 G VV G +K +G IA+ LH G H +A V+++ + Sbjct: 18 GSHMEAPAAVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKERSNTAV 77 Query: 244 TILADI 249 AD+ Sbjct: 78 VCQADL 83 >4H0F-A nrPDB Length = 264 Score = 27.7 bits (60), Expect = 8.2, Method: Composition-based stats. Identities = 14/52 (26%), Positives = 24/52 (46%), Gaps = 5/52 (9%) Query: 225 DATVTISHRYTPK---EQLKKHTILADIVISAAGIPNLITADMIKEGAAVID 273 DA + + H +T + L + + + + A P +T D +K GA V D Sbjct: 49 DADLFVYHSHTLEAWARDLDPNLKKSKVNVFEASKP--LTLDRVKPGATVYD 98 >1UZM-A nrPDB Length = 247 Score = 27.3 bits (59), Expect = 9.1, Method: Composition-based stats. Identities = 19/71 (26%), Positives = 28/71 (39%), Gaps = 9/71 (12%) Query: 250 VISAAGIPNLITADM-------IKEGAAVIDVGINRVHDPVTAKPKLVGDVDFEGVRQKA 302 V + P I DM I++GA + RV P +V + E + Sbjct: 176 VTANVVAPGYIDTDMTRALDERIQQGALQF-IPAKRVGTPAEVAG-VVSFLASEDASYIS 233 Query: 303 GYITPVPGGVG 313 G + PV GG+G Sbjct: 234 GAVIPVDGGMG 244 >1JEO-A nrPDB Length = 180 Score = 27.3 bits (59), Expect = 9.6, Method: Composition-based stats. Identities = 21/77 (27%), Positives = 27/77 (35%), Gaps = 16/77 (20%) Query: 180 VWEIIKRTGIPTLGKNVVVAGRSKNVGMPIAMLLHTDGAHERPGGDATVTISHRYTPKEQ 239 + IIK I G GRS +G AM L G G+ T Y + Sbjct: 34 IDRIIKAKKIFIFG-----VGRSGYIGRCFAMRLMHLGFKSYFVGETTTP---SYEKDDL 85 Query: 240 LKKHTILADIVISAAGI 256 L I+IS +G Sbjct: 86 L--------ILISGSGR 94 >4Y4M-A nrPDB Length = 290 Score = 27.3 bits (59), Expect = 9.8, Method: Composition-based stats. Identities = 16/64 (25%), Positives = 24/64 (37%), Gaps = 1/64 (1%) Query: 210 AMLLHTDGAHERPGGDATVTISHRYTPKEQLKKHTILADIVISAAGIPNLITADMI-KEG 268 M+ + + D T T + + AD+VI AG L A + KEG Sbjct: 23 HMVNLMNIKDIKLNADETKTTKAILKASFDMWLDIVEADVVIVGAGPSGLTCARYLAKEG 82 Query: 269 AAVI 272 V+ Sbjct: 83 FKVV 86 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.313 0.136 0.362 Lambda K H 0.267 0.0416 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,967,245 Number of Sequences: 36641 Number of extensions: 526116 Number of successful extensions: 2107 Number of sequences better than 10.0: 79 Number of HSP's better than 10.0 without gapping: 45 Number of HSP's successfully gapped in prelim test: 69 Number of HSP's that attempted gapping in prelim test: 1956 Number of HSP's gapped (non-prelim): 120 length of query: 350 length of database: 10,336,785 effective HSP length: 98 effective length of query: 252 effective length of database: 6,745,967 effective search space: 1699983684 effective search space used: 1699983684 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 60 (27.7 bits)