BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P12931 (536 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2H8H-A nrPDB 1117 0.0 6F3F-A nrPDB 943 0.0 5SYS-A nrPDB 588 e-168 1AD5-A nrPDB 575 e-164 2DQ7-X nrPDB 506 e-144 2PL0-A nrPDB 407 e-114 2HK5-A nrPDB 404 e-113 3A4O-X nrPDB 402 e-112 2FO0-A nrPDB 369 e-102 4CSV-A nrPDB 348 4e-96 4XEY-B nrPDB 327 7e-90 4XI2-A nrPDB 321 4e-88 1K9A-A nrPDB 303 2e-82 5H2U-A nrPDB 281 4e-76 2XYN-A nrPDB 267 7e-72 6NPU-A nrPDB 265 3e-71 4Y93-A nrPDB 243 2e-64 3SXS-A nrPDB 241 7e-64 6E4F-A nrPDB 237 8e-63 4E93-A nrPDB 231 5e-61 2Y6O-A nrPDB 229 3e-60 3QGY-A nrPDB 228 4e-60 1JPA-A nrPDB 228 5e-60 4P5Q-A nrPDB 226 2e-59 2R2P-A nrPDB 225 3e-59 4PDO-A nrPDB 224 1e-58 3DKO-A nrPDB 223 1e-58 5MJB-A nrPDB 223 2e-58 2VWV-A nrPDB 222 4e-58 5L6P-A nrPDB 221 5e-58 1BYG-A nrPDB 216 3e-56 3KUL-B nrPDB 212 4e-55 2OZO-A nrPDB 209 3e-54 4EBW-A nrPDB 206 2e-53 2J0K-A nrPDB 203 2e-52 3ZBF-A nrPDB 203 2e-52 4HZS-A nrPDB 198 5e-51 1U54-B nrPDB 198 6e-51 4XCU-A nrPDB 198 6e-51 2OGV-A nrPDB 196 3e-50 4R7H-A nrPDB 193 1e-49 4H1J-A nrPDB 189 2e-48 3BEA-A nrPDB 189 3e-48 3I81-A nrPDB 189 3e-48 5AMN-A nrPDB 188 5e-48 6GQK-A nrPDB 188 6e-48 5GRN-A nrPDB 187 1e-47 4XLV-A nrPDB 187 1e-47 3KRL-A nrPDB 186 3e-47 2PSQ-A nrPDB 184 6e-47 5FM2-A nrPDB 184 1e-46 5A46-A nrPDB 183 2e-46 3V5Q-A nrPDB 182 4e-46 6BSD-A nrPDB 182 4e-46 4AT3-A nrPDB 180 1e-45 5U6B-A nrPDB 180 1e-45 5X02-A nrPDB 180 1e-45 1U59-A nrPDB 180 1e-45 4XUF-A nrPDB 180 1e-45 6FEX-A nrPDB 180 2e-45 3TT0-A nrPDB 179 3e-45 3GQL-A nrPDB 179 3e-45 4K33-A nrPDB 177 8e-45 5KMM-A nrPDB 177 1e-44 5EG3-A nrPDB 176 3e-44 3AOX-A nrPDB 176 3e-44 3BBT-B nrPDB 175 5e-44 3G0E-A nrPDB 174 6e-44 3ZZW-A nrPDB 174 1e-43 3QUP-A nrPDB 172 3e-43 6FER-A nrPDB 172 4e-43 3PP0-A nrPDB 171 5e-43 5U6C-A nrPDB 171 8e-43 3PLS-A nrPDB 170 2e-42 4FL3-A nrPDB 170 2e-42 5HLW-A nrPDB 168 5e-42 1LUF-A nrPDB 167 7e-42 5C26-A nrPDB 167 9e-42 1FVR-A nrPDB 166 3e-41 3C1X-A nrPDB 166 3e-41 3CJF-A nrPDB 162 2e-40 3LZB-A nrPDB 157 1e-38 5GNK-A nrPDB 156 2e-38 3OMV-A nrPDB 155 4e-38 6DBN-A nrPDB 155 4e-38 4LRM-A nrPDB 153 1e-37 5HIE-A nrPDB 152 4e-37 5HI2-A nrPDB 151 7e-37 5WNO-A nrPDB 149 3e-36 3LMG-A nrPDB 146 2e-35 6DBM-A nrPDB 143 2e-34 4OLI-A nrPDB 142 4e-34 4HVI-A nrPDB 139 3e-33 4E20-A nrPDB 139 3e-33 4RT7-A nrPDB 138 8e-33 3PPZ-A nrPDB 136 2e-32 5X5O-A nrPDB 135 4e-32 4UYA-A nrPDB 135 6e-32 2W1I-A nrPDB 134 7e-32 5VO2-A nrPDB 133 2e-31 3IO7-A nrPDB 132 3e-31 3VHK-A nrPDB 132 4e-31 3DTC-A nrPDB 128 6e-30 5HVK-A nrPDB 128 6e-30 4UY9-A nrPDB 128 7e-30 3HNG-A nrPDB 127 1e-29 6AMW-A nrPDB 116 3e-26 4M4Z-A nrPDB 110 2e-24 4GS6-A nrPDB 109 3e-24 4YFF-A nrPDB 108 4e-24 2ABL-A nrPDB 108 6e-24 4NEU-A nrPDB 108 8e-24 5UIU-A nrPDB 106 2e-23 4TPT-A nrPDB 105 4e-23 4QMW-A nrPDB 101 7e-22 5XD6-A nrPDB 101 8e-22 2QNJ-A nrPDB 100 3e-21 5ES1-A nrPDB 99 4e-21 2HAK-A nrPDB 99 4e-21 6C9D-A nrPDB 99 4e-21 4MVF-A nrPDB 98 8e-21 3IS5-A nrPDB 98 9e-21 4FZF-B nrPDB 98 1e-20 3DAK-A nrPDB 97 2e-20 5DBX-A nrPDB 96 4e-20 3LIJ-A nrPDB 96 5e-20 4I6B-A nrPDB 96 5e-20 5KZ7-A nrPDB 94 1e-19 4F0G-A nrPDB 94 1e-19 4APC-A nrPDB 94 1e-19 4REW-A nrPDB 94 2e-19 5EZV-A nrPDB 94 2e-19 4CFF-A nrPDB 94 2e-19 4CFH-A nrPDB 94 2e-19 2XIK-A nrPDB 93 3e-19 4L00-A nrPDB 92 4e-19 2YZA-A nrPDB 92 6e-19 1GRI-A nrPDB 92 7e-19 6J5U-C nrPDB 92 8e-19 4RGJ-A nrPDB 91 9e-19 4RED-A nrPDB 91 1e-18 3HZT-A nrPDB 91 1e-18 3MDY-A nrPDB 91 1e-18 4YNZ-A nrPDB 91 1e-18 3DXN-A nrPDB 91 2e-18 5WNL-A nrPDB 90 2e-18 5LPZ-A nrPDB 89 4e-18 3Q5I-A nrPDB 89 4e-18 5LPV-A nrPDB 89 5e-18 5TOS-A nrPDB 89 6e-18 6CTH-A nrPDB 88 8e-18 3NCG-A nrPDB 87 1e-17 5JN2-A nrPDB 87 1e-17 3OHT-A nrPDB 87 2e-17 3COM-A nrPDB 87 2e-17 5USZ-A nrPDB 87 2e-17 3DFA-A nrPDB 87 3e-17 5F9E-A nrPDB 87 3e-17 5NGU-A nrPDB 87 3e-17 4EWQ-A nrPDB 86 3e-17 3MA6-A nrPDB 86 4e-17 4AU8-A nrPDB 86 5e-17 4KRC-A nrPDB 86 6e-17 2WQN-A nrPDB 85 6e-17 5EFQ-A nrPDB 85 6e-17 4NST-A nrPDB 85 6e-17 6QAU-A nrPDB 85 6e-17 4B6L-A nrPDB 85 7e-17 4JXF-A nrPDB 85 7e-17 2QKW-B nrPDB 85 7e-17 2X4F-A nrPDB 84 1e-16 5YKS-A nrPDB 84 1e-16 4AN9-A nrPDB 84 1e-16 4D2V-A nrPDB 84 1e-16 4M66-A nrPDB 84 1e-16 3REP-A nrPDB 84 2e-16 4WNO-A nrPDB 84 2e-16 1U5R-A nrPDB 84 2e-16 5D7A-A nrPDB 84 2e-16 5C01-A nrPDB 83 2e-16 2BPM-A nrPDB 83 2e-16 4WOV-A nrPDB 83 3e-16 4QTB-A nrPDB 83 3e-16 2JAM-A nrPDB 83 3e-16 2Y4I-B nrPDB 83 3e-16 2GCD-A nrPDB 83 3e-16 6FDY-U nrPDB 83 3e-16 3UIM-A nrPDB 82 4e-16 5G6V-A nrPDB 82 4e-16 3T04-A nrPDB 82 5e-16 4CQG-A nrPDB 82 7e-16 4RA4-A nrPDB 82 8e-16 3NIZ-A nrPDB 81 9e-16 6GU6-A nrPDB 81 1e-15 4LG4-A nrPDB 81 1e-15 1CM8-A nrPDB 81 1e-15 5D9K-A nrPDB 80 2e-15 3PFQ-A nrPDB 80 2e-15 2BRG-A nrPDB 80 2e-15 3H4J-B nrPDB 80 2e-15 2Z7Q-A nrPDB 80 2e-15 6AO5-A nrPDB 80 3e-15 3GC9-A nrPDB 79 4e-15 5XZW-A nrPDB 79 4e-15 6CQF-A nrPDB 79 4e-15 2F57-A nrPDB 79 4e-15 2I0E-A nrPDB 79 5e-15 4EQM-A nrPDB 79 7e-15 6CMJ-A nrPDB 79 7e-15 3Q4U-A nrPDB 78 8e-15 2F9G-A nrPDB 78 1e-14 3MN3-A nrPDB 78 1e-14 1PY5-A nrPDB 78 1e-14 4D28-A nrPDB 78 1e-14 5TQX-A nrPDB 78 1e-14 4PDS-A nrPDB 77 1e-14 6BFN-A nrPDB 77 1e-14 4U41-A nrPDB 77 2e-14 1V0B-A nrPDB 77 3e-14 3MY0-A nrPDB 76 3e-14 3MIA-A nrPDB 76 3e-14 3ORP-A nrPDB 76 3e-14 4MYG-A nrPDB 76 4e-14 4KS7-A nrPDB 76 4e-14 4BBM-A nrPDB 76 4e-14 4M69-B nrPDB 75 7e-14 5J5T-A nrPDB 75 1e-13 6CCF-A nrPDB 74 1e-13 4BTF-A nrPDB 74 1e-13 3ZDU-A nrPDB 74 1e-13 1KOA-A nrPDB 74 2e-13 4FIE-A nrPDB 74 2e-13 5YV8-A nrPDB 74 2e-13 3F3Z-A nrPDB 74 2e-13 2OU7-A nrPDB 74 2e-13 3UTO-A nrPDB 73 2e-13 2J90-A nrPDB 73 2e-13 2XNP-A nrPDB 73 3e-13 1KOB-A nrPDB 73 3e-13 4XBR-A nrPDB 73 3e-13 1FOT-A nrPDB 73 4e-13 4JDH-A nrPDB 72 4e-13 4J52-A nrPDB 72 4e-13 5AR8-A nrPDB 72 5e-13 1S9I-A nrPDB 72 5e-13 6FD3-A nrPDB 72 5e-13 2Q0N-A nrPDB 72 7e-13 2JC6-A nrPDB 72 7e-13 3HKO-A nrPDB 72 8e-13 6E2O-A nrPDB 72 9e-13 5KKR-C nrPDB 71 1e-12 3Q53-A nrPDB 71 1e-12 3EQC-A nrPDB 71 1e-12 3ORZ-A nrPDB 71 1e-12 5Z33-A nrPDB 70 2e-12 4UZD-A nrPDB 70 2e-12 4PWN-A nrPDB 70 2e-12 5O2C-A nrPDB 70 2e-12 3TKU-A nrPDB 70 2e-12 4CZT-A nrPDB 70 2e-12 4X3F-A nrPDB 70 2e-12 6DTL-A nrPDB 69 4e-12 4OW8-A nrPDB 69 4e-12 3GUB-A nrPDB 69 4e-12 5O2B-A nrPDB 69 4e-12 3DB8-A nrPDB 69 5e-12 2I6L-A nrPDB 69 6e-12 4C0T-A nrPDB 69 6e-12 2WTK-C nrPDB 69 6e-12 2UV2-A nrPDB 69 6e-12 4L42-A nrPDB 69 6e-12 6B2Q-A nrPDB 69 7e-12 1G3N-A nrPDB 68 8e-12 4AW2-A nrPDB 68 9e-12 4BGQ-A nrPDB 68 9e-12 3LM0-A nrPDB 68 9e-12 3RP9-A nrPDB 68 1e-11 1UA2-A nrPDB 68 1e-11 4RLP-A nrPDB 68 1e-11 4TNB-A nrPDB 68 1e-11 2W4O-A nrPDB 68 1e-11 1VZO-A nrPDB 67 1e-11 4L68-A nrPDB 67 1e-11 4WB7-A nrPDB 67 1e-11 4IC8-A nrPDB 67 2e-11 4KIK-B nrPDB 67 2e-11 4CRS-A nrPDB 67 2e-11 3QA8-A nrPDB 67 2e-11 4IAN-A nrPDB 67 2e-11 3D2K-A nrPDB 67 2e-11 5X3F-B nrPDB 67 2e-11 5B2L-A nrPDB 67 2e-11 4YZB-A nrPDB 67 2e-11 4FG9-A nrPDB 67 3e-11 5N23-A nrPDB 67 3e-11 2XS0-A nrPDB 66 4e-11 1ZWS-A nrPDB 66 4e-11 4ZSG-A nrPDB 66 5e-11 4O2Z-A nrPDB 66 5e-11 3ALO-A nrPDB 65 5e-11 2A27-A nrPDB 65 5e-11 3NYO-A nrPDB 65 5e-11 4AGU-A nrPDB 65 6e-11 6BDL-A nrPDB 65 6e-11 5IG1-A nrPDB 65 6e-11 4MWI-A nrPDB 65 6e-11 5JZN-A nrPDB 65 7e-11 3VN9-A nrPDB 65 8e-11 1ZXE-A nrPDB 65 9e-11 3GC0-A nrPDB 65 9e-11 6HXF-B nrPDB 65 9e-11 3KK8-A nrPDB 65 1e-10 2BDW-A nrPDB 65 1e-10 4FR4-A nrPDB 64 1e-10 5LOH-A nrPDB 64 1e-10 3HDN-A nrPDB 64 2e-10 3FME-A nrPDB 64 2e-10 2YAB-A nrPDB 64 2e-10 3FI2-A nrPDB 64 2e-10 1JNK-A nrPDB 64 2e-10 1A81-A nrPDB 64 2e-10 6E9W-A nrPDB 64 2e-10 4JLC-A nrPDB 64 2e-10 4EUU-A nrPDB 63 3e-10 4EUT-A nrPDB 63 3e-10 5E8V-A nrPDB 63 3e-10 6NT9-A nrPDB 63 4e-10 2QLU-A nrPDB 63 4e-10 3N9X-A nrPDB 63 4e-10 4XZ1-A nrPDB 63 4e-10 5O0Y-A nrPDB 62 4e-10 3TXO-A nrPDB 62 5e-10 4I94-A nrPDB 62 5e-10 2JDO-A nrPDB 62 6e-10 2RIO-A nrPDB 62 6e-10 3KN6-A nrPDB 62 7e-10 3UIU-A nrPDB 62 7e-10 6ED6-A nrPDB 62 7e-10 4OTD-A nrPDB 62 7e-10 6O8B-A nrPDB 62 7e-10 5U6Y-A nrPDB 62 8e-10 5TUR-A nrPDB 62 9e-10 3OZ6-A nrPDB 62 9e-10 2A1A-B nrPDB 62 9e-10 3MV5-A nrPDB 62 9e-10 5KCV-A nrPDB 61 1e-09 3BGP-A nrPDB 61 1e-09 4RC3-A nrPDB 61 1e-09 3BHH-A nrPDB 61 1e-09 2VZ6-A nrPDB 60 2e-09 2YCR-A nrPDB 60 2e-09 4YHJ-A nrPDB 60 2e-09 4QNY-A nrPDB 60 2e-09 3I6U-A nrPDB 60 2e-09 3SV0-A nrPDB 60 3e-09 3SOC-A nrPDB 60 3e-09 4TN6-A nrPDB 60 3e-09 3SOA-A nrPDB 60 3e-09 4Y83-A nrPDB 59 4e-09 5AWM-A nrPDB 59 5e-09 3DLS-A nrPDB 59 5e-09 2V7O-A nrPDB 59 5e-09 4AF3-A nrPDB 59 5e-09 3C51-A nrPDB 59 5e-09 4B8L-A nrPDB 59 6e-09 5JMQ-A nrPDB 59 6e-09 3NIE-A nrPDB 59 7e-09 2WTK-B nrPDB 59 7e-09 2Y7J-A nrPDB 58 1e-08 2W96-B nrPDB 58 1e-08 4CRL-A nrPDB 57 1e-08 5FQD-C nrPDB 57 1e-08 2PMN-X nrPDB 57 2e-08 4M7I-A nrPDB 57 2e-08 3E7O-A nrPDB 57 2e-08 5VD3-A nrPDB 57 2e-08 4C59-A nrPDB 57 2e-08 6HV0-A nrPDB 57 2e-08 3G2F-A nrPDB 57 3e-08 4JG6-A nrPDB 56 4e-08 5FET-A nrPDB 56 4e-08 1PHK-A nrPDB 56 4e-08 2VN9-A nrPDB 56 5e-08 4NFN-A nrPDB 56 5e-08 4BTK-A nrPDB 55 5e-08 6O6Q-A nrPDB 55 5e-08 4X7Q-B nrPDB 55 5e-08 5VDK-A nrPDB 55 7e-08 4E7W-A nrPDB 55 8e-08 5FG8-A nrPDB 55 9e-08 3RAW-A nrPDB 55 9e-08 3GF9-A nrPDB 55 9e-08 4NIF-A nrPDB 54 1e-07 3UDB-A nrPDB 54 1e-07 4PL5-B nrPDB 54 1e-07 5X8I-B nrPDB 54 1e-07 5IKW-A nrPDB 54 1e-07 5DYK-A nrPDB 54 2e-07 5Y86-A nrPDB 54 2e-07 2VD5-A nrPDB 54 2e-07 2BUJ-A nrPDB 54 2e-07 3QWY-A nrPDB 54 2e-07 1NY3-A nrPDB 54 2e-07 2OZA-A nrPDB 54 2e-07 2H34-A nrPDB 53 3e-07 3FXW-A nrPDB 53 3e-07 2LQW-A nrPDB 53 3e-07 5UNP-A nrPDB 53 3e-07 5VC6-A nrPDB 53 3e-07 3KA0-A nrPDB 53 4e-07 2AUG-A nrPDB 52 5e-07 2ZMD-A nrPDB 52 5e-07 3A8W-A nrPDB 52 5e-07 5WAX-A nrPDB 52 5e-07 5UV4-A nrPDB 52 6e-07 5ZTN-A nrPDB 52 6e-07 3PG1-A nrPDB 52 6e-07 3HMP-A nrPDB 52 7e-07 2CMW-A nrPDB 52 7e-07 6GVJ-A nrPDB 52 8e-07 3JV3-A nrPDB 52 8e-07 2EKX-A nrPDB 52 8e-07 5J0A-A nrPDB 51 1e-06 2WO6-A nrPDB 51 1e-06 3HAJ-A nrPDB 51 1e-06 4LFI-A nrPDB 51 1e-06 4H1O-A nrPDB 51 1e-06 3E3P-A nrPDB 51 1e-06 5AP3-A nrPDB 51 2e-06 4BNE-A nrPDB 50 2e-06 2EOB-A nrPDB 50 2e-06 6CMQ-A nrPDB 50 2e-06 1GCQ-A nrPDB 50 2e-06 6FYV-A nrPDB 50 2e-06 2JD5-A nrPDB 50 2e-06 3UC3-A nrPDB 50 3e-06 3QD2-B nrPDB 50 3e-06 1MIL-A nrPDB 50 3e-06 3EHQ-A nrPDB 50 3e-06 4XHH-A nrPDB 49 5e-06 5AIR-A nrPDB 49 6e-06 3ZUT-A nrPDB 49 8e-06 1TKI-A nrPDB 48 1e-05 5NP2-A nrPDB 48 1e-05 5U06-A nrPDB 47 3e-05 2CUC-A nrPDB 47 3e-05 4IDT-A nrPDB 46 3e-05 4XHL-A nrPDB 46 3e-05 2CRH-A nrPDB 46 4e-05 2EYZ-A nrPDB 46 5e-05 1UHF-A nrPDB 45 6e-05 4Y12-A nrPDB 45 6e-05 5X1R-A nrPDB 45 6e-05 2V1Q-A nrPDB 45 9e-05 5GZA-A nrPDB 45 9e-05 2PLE-A nrPDB 45 1e-04 6F55-A nrPDB 45 1e-04 2PZI-A nrPDB 45 1e-04 2X3W-D nrPDB 45 1e-04 6BXI-A nrPDB 44 1e-04 2JT4-A nrPDB 44 2e-04 2CUD-A nrPDB 44 2e-04 3M42-A nrPDB 44 3e-04 1NRV-A nrPDB 43 3e-04 6CKI-A nrPDB 43 3e-04 2C47-A nrPDB 43 4e-04 5M6U-B nrPDB 43 4e-04 4MD7-E nrPDB 43 4e-04 1UEC-A nrPDB 42 5e-04 2KK6-A nrPDB 42 6e-04 6EII-A nrPDB 42 6e-04 4F9B-A nrPDB 42 6e-04 2B3O-A nrPDB 42 6e-04 5UUU-A nrPDB 42 7e-04 1GBQ-A nrPDB 42 7e-04 3EB0-A nrPDB 42 7e-04 2YUP-A nrPDB 42 8e-04 3PS5-A nrPDB 42 8e-04 3PVW-A nrPDB 42 9e-04 1KA6-A nrPDB 42 0.001 4G3E-A nrPDB 41 0.001 1M27-A nrPDB 41 0.001 1OV3-A nrPDB 41 0.001 4LQP-A nrPDB 41 0.001 4JGH-A nrPDB 41 0.002 4N78-F nrPDB 40 0.002 2CT4-A nrPDB 40 0.002 2CHL-A nrPDB 40 0.002 5TE0-A nrPDB 40 0.003 3LLT-A nrPDB 40 0.003 5XVU-A nrPDB 40 0.003 2VKN-A nrPDB 40 0.003 2HSP-A nrPDB 39 0.004 5VEI-A nrPDB 39 0.005 2ED0-A nrPDB 39 0.007 2EQI-A nrPDB 39 0.008 1YWO-A nrPDB 39 0.008 3ULR-B nrPDB 38 0.009 2VIF-A nrPDB 38 0.010 4JRN-A nrPDB 38 0.013 >2H8H-A nrPDB Length = 535 Score = 1117 bits (2888), Expect = 0.0, Method: Compositional matrix adjust. Identities = 535/535 (100%), Positives = 535/535 (100%) Query: 2 GSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEP 61 GSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEP Sbjct: 1 GSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEP 60 Query: 62 KLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 121 KLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW Sbjct: 61 KLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 120 Query: 122 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 181 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE Sbjct: 121 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 180 Query: 182 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 241 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC Sbjct: 181 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 240 Query: 242 HRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLK 301 HRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLK Sbjct: 241 HRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLK 300 Query: 302 PGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYL 361 PGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYL Sbjct: 301 PGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYL 360 Query: 362 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA 421 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA Sbjct: 361 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA 420 Query: 422 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG Sbjct: 421 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 480 Query: 482 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL Sbjct: 481 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 535 >6F3F-A nrPDB Length = 455 Score = 943 bits (2437), Expect = 0.0, Method: Compositional matrix adjust. Identities = 449/451 (99%), Positives = 451/451 (100%) Query: 86 VTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDS 145 VTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDS Sbjct: 5 VTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDS 64 Query: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY Sbjct: 65 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 124 Query: 206 KIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEI 265 KIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEI Sbjct: 125 KIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEI 184 Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKL 325 PRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKL Sbjct: 185 PRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKL 244 Query: 326 VQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 VQLYAVVSEEPIYIVTEYM+KGSLLDFLKGETGKYLRLPQLVDM+AQIASGMAYVERMNY Sbjct: 245 VQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNY 304 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK Sbjct: 305 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 364 Query: 446 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKE 505 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKE Sbjct: 365 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKE 424 Query: 506 PEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536 PEERPTFEYLQAFLEDYFTSTEPQYQPGENL Sbjct: 425 PEERPTFEYLQAFLEDYFTSTEPQYQPGENL 455 >5SYS-A nrPDB Length = 286 Score = 588 bits (1516), Expect = e-168, Method: Compositional matrix adjust. Identities = 280/283 (98%), Positives = 281/283 (99%) Query: 254 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQE 313 QTQGLAKDAWEIPRESLRLEVKLGQGCFGE WMGTWNGTTRVAIKTLKPGTMSPEAFLQE Sbjct: 4 QTQGLAKDAWEIPRESLRLEVKLGQGCFGECWMGTWNGTTRVAIKTLKPGTMSPEAFLQE 63 Query: 314 AQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373 AQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGE GKYLRLPQLVDMAAQI Sbjct: 64 AQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQI 123 Query: 374 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 433 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA Sbjct: 124 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 183 Query: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES 493 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES Sbjct: 184 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES 243 Query: 494 LHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536 LHDLMCQCWRK+PEERPTFEYLQAFLEDYFTSTEPQYQPGENL Sbjct: 244 LHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 286 >1AD5-A nrPDB Length = 438 Score = 575 bits (1481), Expect = e-164, Method: Compositional matrix adjust. Identities = 270/442 (61%), Positives = 348/442 (78%), Gaps = 12/442 (2%) Query: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149 VALYDYE+ DLSF+KG+++ ++ + G+WW A SL+T + GYIPSNYVA DS++ E Sbjct: 6 VALYDYEAIHHEDLSFQKGDQMVVLEES-GEWWKARSLATRKEGYIPSNYVARVDSLETE 64 Query: 150 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209 EW+F I+R+++ER LL N G+F++R+SETTKG+Y LSV D+D +G VKHYKIR Sbjct: 65 EWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRT 124 Query: 210 LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRES 269 LD+GGFYI+ R+ F++LQ+LV +Y K DGLC +L+ C +SKPQ + KDAWEIPRES Sbjct: 125 LDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQ-KPWEKDAWEIPRES 183 Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329 L+LE KLG G FGEVWM T+N T+VA+KT+KPG+MS EAFL EA VMK L+H+KLV+L+ Sbjct: 184 LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLH 243 Query: 330 AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 AVV++EPIYI+TE+M+KGSLLDFLK + G LP+L+D +AQIA GMA++E+ NY+HRD Sbjct: 244 AVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRD 303 Query: 390 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 449 LRAANILV +LVCK+ADFGLAR+ GAKFPIKWTAPEA +G FTIKSDVW Sbjct: 304 LRAANILVSASLVCKIADFGLARV----------GAKFPIKWTAPEAINFGSFTIKSDVW 353 Query: 450 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEER 509 SFGILL E+ T GR+PYPGM N EV+ +ERGYRMP P CPE L+++M +CW+ PEER Sbjct: 354 SFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEER 413 Query: 510 PTFEYLQAFLEDYFTSTEPQYQ 531 PTFEY+Q+ L+D++T+TE QYQ Sbjct: 414 PTFEYIQSVLDDFYTATESQYQ 435 >2DQ7-X nrPDB Length = 283 Score = 506 bits (1304), Expect = e-144, Method: Compositional matrix adjust. Identities = 233/277 (84%), Positives = 258/277 (93%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKK 319 KD WEIPRESL+L +LG G FGEVWMGTWNG T+VAIKTLKPGTMSPE+FL+EAQ+MKK Sbjct: 1 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKK 60 Query: 320 LRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 L+H+KLVQLYAVVSEEPIYIVTEYM+KGSLLDFLK G+ L+LP LVDMAAQ+A+GMAY Sbjct: 61 LKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAY 120 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 +ERMNY+HRDLR+ANILVG L+CK+ADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY Sbjct: 121 IERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 180 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMC 499 GRFTIKSDVWSFGILLTEL TKGRVPYPGM NREVL+QVERGYRMPCP +CP SLH+LM Sbjct: 181 GRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMI 240 Query: 500 QCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536 CW+K+PEERPTFEYLQ+FLEDYFT+TEPQYQPGENL Sbjct: 241 HCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 277 >2PL0-A nrPDB Length = 289 Score = 407 bits (1045), Expect = e-114, Method: Compositional matrix adjust. Identities = 189/283 (66%), Positives = 234/283 (82%), Gaps = 1/283 (0%) Query: 250 TSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA 309 T KPQ + +D WE+PRE+L+L +LG G FGEVWMG +NG T+VA+K+LK G+MSP+A Sbjct: 6 TQKPQ-KPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDA 64 Query: 310 FLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDM 369 FL EA +MK+L+H++LV+LYAVV++EPIYI+TEYM GSL+DFLK +G L + +L+DM Sbjct: 65 FLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDM 124 Query: 370 AAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 429 AAQIA GMA++E NY+HRDLRAANILV + L CK+ADFGLARLIEDNEYTAR+GAKFPI Sbjct: 125 AAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPI 184 Query: 430 KWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE 489 KWTAPEA YG FTIKSDVWSFGILLTE+ T GR+PYPGM N EV+ +ERGYRM P Sbjct: 185 KWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDN 244 Query: 490 CPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQP 532 CPE L+ LM CW++ PE+RPTF+YL++ LED+FT+TE QYQP Sbjct: 245 CPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQP 287 >2HK5-A nrPDB Length = 270 Score = 404 bits (1039), Expect = e-113, Method: Compositional matrix adjust. Identities = 183/263 (69%), Positives = 224/263 (85%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKK 319 KDAWEIPRESL+LE KLG G FGEVWM T+N T+VA+KT+KPG+MS EAFL EA VMK Sbjct: 7 KDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKT 66 Query: 320 LRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 L+H+KLV+L+AVV++EPIYI+TE+M+KGSLLDFLK + G LP+L+D +AQIA GMA+ Sbjct: 67 LQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAF 126 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 +E+ NY+HRDLRAANILV +LVCK+ADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA + Sbjct: 127 IEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINF 186 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMC 499 G FTIKSDVWSFGILL E+ T GR+PYPGM N EV+ +ERGYRMP P CPE L+++M Sbjct: 187 GSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMM 246 Query: 500 QCWRKEPEERPTFEYLQAFLEDY 522 +CW+ PEERPTFEY+Q+ L+D+ Sbjct: 247 RCWKNRPEERPTFEYIQSVLDDF 269 >3A4O-X nrPDB Length = 286 Score = 402 bits (1033), Expect = e-112, Method: Compositional matrix adjust. Identities = 183/273 (67%), Positives = 232/273 (84%), Gaps = 1/273 (0%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKK 319 KDAWEIPRES++L +LG G FGEVWMG +N +T+VA+KTLKPGTMS +AFL+EA +MK Sbjct: 5 KDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKT 64 Query: 320 LRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378 L+H+KLV+LYAVV+ EEPIYI+TEYM+KGSLLDFLK + G + LP+L+D +AQIA GMA Sbjct: 65 LQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMA 124 Query: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438 Y+ER NY+HRDLRAAN+LV E+L+CK+ADFGLAR+IEDNEYTAR+GAKFPIKWTAPEA Sbjct: 125 YIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 184 Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM 498 +G FTIKSDVWSFGILL E+ T G++PYPG N +V+ + +GYRMP CP+ L+D+M Sbjct: 185 FGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIM 244 Query: 499 CQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQ 531 CW+++ EERPTF+YLQ+ L+D++T+TE QYQ Sbjct: 245 KMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQ 277 >2FO0-A nrPDB Length = 495 Score = 369 bits (946), Expect = e-102, Method: Compositional matrix adjust. Identities = 198/451 (43%), Positives = 285/451 (63%), Gaps = 15/451 (3%) Query: 79 AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVN-NTEGDWWLAHSLSTGQTGYIPS 137 AGP FVALYD+ + + LS KGE+L+++ N G+W A + GQ G++PS Sbjct: 33 AGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT-KNGQ-GWVPS 90 Query: 138 NYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNA 197 NY+ P +S++ WY G ++R +E LL + N G+FLVRESE++ G +S+ Sbjct: 91 NYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISL----RY 144 Query: 198 KGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQ 256 +G V HY+I G Y++S ++FN+L +LV ++S ADGL L P +KP Sbjct: 145 EG-RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVY 203 Query: 257 GLAK--DAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQE 313 G++ D WE+ R + ++ KLG G +GEV+ G W + VA+KTLK TM E FL+E Sbjct: 204 GVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKE 263 Query: 314 AQVMKKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQ 372 A VMK+++H LVQL V + EP YI+TE+M+ G+LLD+L+ + + L+ MA Q Sbjct: 264 AAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQ 323 Query: 373 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT 432 I+S M Y+E+ N++HR+L A N LVGEN + KVADFGL+RL+ + YTA GAKFPIKWT Sbjct: 324 ISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 383 Query: 433 APEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE 492 APE+ Y +F+IKSDVW+FG+LL E+ T G PYPG+ +V + +E+ YRM P CPE Sbjct: 384 APESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPE 443 Query: 493 SLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 +++LM CW+ P +RP+F + E F Sbjct: 444 KVYELMRACWQWNPSDRPSFAEIHQAFETMF 474 >4CSV-A nrPDB Length = 275 Score = 348 bits (892), Expect = 4e-96, Method: Compositional matrix adjust. Identities = 173/265 (65%), Positives = 200/265 (75%), Gaps = 2/265 (0%) Query: 261 DAWEIPRESLRLEVKLGQGCFGEVWMGTW-NGTTRVAIKTLKPGTMSPEAFLQEAQVMKK 319 D WEIPR + LE KLG G FGEV+ G W N VA+KTLK GTMS E FLQEAQ+MKK Sbjct: 4 DKWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQIMKK 63 Query: 320 LRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378 L+H LVQLY V ++EP IYI+TEYMS GSLLD+L+ G + L+DMAAQ+ASGMA Sbjct: 64 LKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMA 123 Query: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438 Y+E N++HRDL A N LVGEN V KVADFGLARLI ++EYTAR GAKFPIKWTAPEA Sbjct: 124 YLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTAPEAIS 183 Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM 498 Y RF+IKSDVW+FGILL E+ T G+VPYPGM EV++QVERGYRMP P CPE +++LM Sbjct: 184 YNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCPEEIYELM 243 Query: 499 CQCWRKEPEERPTFEYLQAFLEDYF 523 QCW K PEERPTF LE F Sbjct: 244 LQCWNKSPEERPTFAETLHALETMF 268 >4XEY-B nrPDB Length = 408 Score = 327 bits (838), Expect = 7e-90, Method: Compositional matrix adjust. Identities = 175/385 (45%), Positives = 249/385 (64%), Gaps = 13/385 (3%) Query: 140 VAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKG 199 +A +S++ WY G ++R +E LL + N G+FLVRESE++ G +S+ +G Sbjct: 1 MASVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISL----RYEG 54 Query: 200 LNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGL 258 V HY+I G Y++S ++FN+L +LV ++S ADGL L P +KP G+ Sbjct: 55 -RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGV 113 Query: 259 A--KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQ 315 + D WE+ R + ++ KLG G +GEV+ G W + VA+KTLK TM E FL+EA Sbjct: 114 SPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA 173 Query: 316 VMKKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 374 VMK+++H LVQL V + EP YI+TE+M+ G+LLD+L+ + + L+ MA QI+ Sbjct: 174 VMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQIS 233 Query: 375 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 434 S M Y+E+ N++HRDL A N LVGEN + KVADFGL+RL+ + YTA GAKFPIKWTAP Sbjct: 234 SAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 293 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESL 494 E+ Y +F+IKSDVW+FG+LL E+ T G PYPG+ +V + +E+ YRM P CPE + Sbjct: 294 ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV 353 Query: 495 HDLMCQCWRKEPEERPTF-EYLQAF 518 ++LM CW+ P +RP+F E QAF Sbjct: 354 YELMRACWQWNPSDRPSFAEIHQAF 378 >4XI2-A nrPDB Length = 446 Score = 321 bits (823), Expect = 4e-88, Method: Compositional matrix adjust. Identities = 172/442 (38%), Positives = 262/442 (59%), Gaps = 18/442 (4%) Query: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPS-DSIQA 148 VALYDY DL +KGE I+ + WW A GQ GYIPSNY+ + DSI+ Sbjct: 7 VALYDYMPMNANDLQLRKGEEYFILEESNLPWWRARD-KNGQEGYIPSNYITEAEDSIEM 65 Query: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGL---NVKHY 205 EWY +TR ++E+LL E G F+VR+S + G Y +SV F + G ++HY Sbjct: 66 YEWYSKHMTRSQAEQLL-KQEGKEGGFIVRDS-SKAGKYTVSV--FAKSTGEPQGVIRHY 121 Query: 206 KIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSK-----PQTQGLAK 260 + +Y+ + F+++ +L+ Y+ ++ GL RL P SK P T GL Sbjct: 122 VVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKY--PVSKQNKNAPSTAGLGY 179 Query: 261 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKL 320 +WEI + L +LG G FG V G W G VAIK ++ G+MS + F++EA+VM L Sbjct: 180 GSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNL 239 Query: 321 RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 HEKLVQLY V +++ PI+I+TEYM+ G LL++L+ E + QL++M + M Y Sbjct: 240 SHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLR-EMRHRFQTQQLLEMCKDVCEAMEY 298 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 +E ++HRDL A N LV + V KV+DFGL+R + D+EYT+ G+KFP++W+ PE +Y Sbjct: 299 LESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMY 358 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMC 499 +F+ KSD+W+FG+L+ E+ + G++PY N E + + +G R+ P E ++ +M Sbjct: 359 SKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMY 418 Query: 500 QCWRKEPEERPTFEYLQAFLED 521 CW ++ +ERP+F+ L + + D Sbjct: 419 SCWHEKADERPSFKILLSNILD 440 >1K9A-A nrPDB Length = 450 Score = 303 bits (775), Expect = 2e-82, Method: Compositional matrix adjust. Identities = 181/444 (40%), Positives = 251/444 (56%), Gaps = 24/444 (5%) Query: 87 TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSI 146 T +A Y++ E DL F KG+ L IV T+ W G+ G IP+NYV + + Sbjct: 12 TECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGV 71 Query: 147 QAEE------WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGL 200 +A W+ GKITR ++ERLL E G FLVRES G Y L VS +G Sbjct: 72 KAGTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVS----CEG- 124 Query: 201 NVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTT--VCPTSKPQTQGL 258 V+HY+I + I F +L QLV +Y+ ADGLC RL V + Sbjct: 125 KVEHYRIM-YHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEF 183 Query: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 318 + W + + L+L +G+G FG+V +G + G +VA+K +K + +AFL EA VM Sbjct: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEASVMT 241 Query: 319 KLRHEKLVQLYAVVSEEP--IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 +LRH LVQL V+ EE +YIVTEYM+KGSL+D+L+ L L+ + + Sbjct: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 M Y+E N+VHRDL A N+LV E+ V KV+DFGL + + T K P+KWTAPEA Sbjct: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEA 357 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 +F+ KSDVWSFGILL E+ + GRVPYP + ++V+ +VE+GY+M P CP +++D Sbjct: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYD 417 Query: 497 LMCQCWRKEPEERPTFEYLQAFLE 520 +M CW + RPTF L+ LE Sbjct: 418 VMKNCWHLDAATRPTFLQLREQLE 441 >5H2U-A nrPDB Length = 267 Score = 281 bits (720), Expect = 4e-76, Method: Compositional matrix adjust. Identities = 142/264 (53%), Positives = 182/264 (68%), Gaps = 4/264 (1%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ-EAQVMKKLRH 322 E PRE L KLG G FGEV+ G W +VAIK + + + LQ E Q MKKLRH Sbjct: 2 ERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRH 61 Query: 323 EKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 + ++ LYAVVS +P+YI+TE M+KGSLL+ L+ K L + +L+D+A Q+A GM Y+E Sbjct: 62 KHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLE 121 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 NY+HRDL A NILVGEN +CKV DFGLARLI+++ Y + P KWTAPEA G Sbjct: 122 SQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLS-HDHNIPYKWTAPEALSRGH 180 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 501 ++ KSDVWSFGILL E+ ++G+VPYPGM N E +V+ GYRMPCP ECP S+H LM C Sbjct: 181 YSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTC 240 Query: 502 WRKEPEERPTFEYLQAFLEDYFTS 525 W ++PE+RPTF+ L+ L FTS Sbjct: 241 WCRDPEQRPTFKALRERLSS-FTS 263 >2XYN-A nrPDB Length = 292 Score = 267 bits (683), Expect = 7e-72, Method: Compositional matrix adjust. Identities = 136/261 (52%), Positives = 179/261 (68%), Gaps = 3/261 (1%) Query: 261 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKK 319 D WE+ R + ++ KLG G +GEV++G W + VA+KTLK TM E FL+EA VMK+ Sbjct: 25 DKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 84 Query: 320 LRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378 ++H LVQL V + E P YIVTEYM G+LLD+L+ + + L+ MA QI+S M Sbjct: 85 IKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAME 144 Query: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438 Y+E+ N++HRDL A N LVGEN V KVADFGL+RL+ + YTA GAKFPIKWTAPE+ Sbjct: 145 YLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA 204 Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM 498 Y F+IKSDVW+FG+LL E+ T G PYPG+ +V D +E+GYRM P CP +++LM Sbjct: 205 YNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELM 264 Query: 499 CQCWRKEPEERPTF-EYLQAF 518 CW+ P +RP+F E QAF Sbjct: 265 RACWKWSPADRPSFAETHQAF 285 >6NPU-A nrPDB Length = 298 Score = 265 bits (677), Expect = 3e-71, Method: Compositional matrix adjust. Identities = 132/261 (50%), Positives = 180/261 (68%), Gaps = 3/261 (1%) Query: 261 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKK 319 D WE+ R + ++ KLG G +GEV+ G W + VA+KTLK TM E FL+EA VMK+ Sbjct: 19 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKE 78 Query: 320 LRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378 ++H LVQL V + EP YI+TE+M+ G+LLD+L+ + + L+ MA QI+S M Sbjct: 79 IKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAME 138 Query: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438 Y+E+ N++HRDL A N LVGEN + KVADFGL+RL+ + YTA GAKFPIKWTAPE+ Sbjct: 139 YLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLA 198 Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM 498 Y +F+IKSDVW+FG+LL E+ T G PYPG+ +V + +E+ YRM P CPE +++LM Sbjct: 199 YNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELM 258 Query: 499 CQCWRKEPEERPTF-EYLQAF 518 CW+ P +RP+F E QAF Sbjct: 259 RACWQWNPSDRPSFAEIHQAF 279 >4Y93-A nrPDB Length = 446 Score = 243 bits (619), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 115/270 (42%), Positives = 173/270 (64%), Gaps = 2/270 (0%) Query: 253 PQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ 312 P T GL +WEI + L +LG G FG V G W G VAIK +K G+MS + F++ Sbjct: 173 PSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIE 232 Query: 313 EAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA 371 EA+VM L HEKLVQLY V +++ PI+I+TEYM+ G LL++L+ E + QL++M Sbjct: 233 EAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLR-EMRHRFQTQQLLEMCK 291 Query: 372 QIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKW 431 + M Y+E ++HRDL A N LV + V KV+DFG+ R + D+EYT+ G+KFP+KW Sbjct: 292 DVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKW 351 Query: 432 TAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP 491 +PE +Y +F+ KSD+W+FG+L+ E+ + G++PY N E + + +G R+P P Sbjct: 352 ASPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLAS 411 Query: 492 ESLHDLMCQCWRKEPEERPTFEYLQAFLED 521 E ++ +M CW ++ +ERPTF+ L + + D Sbjct: 412 ERVYAIMYSCWHEKADERPTFKILLSNILD 441 >3SXS-A nrPDB Length = 268 Score = 241 bits (614), Expect = 7e-64, Method: Compositional matrix adjust. Identities = 117/258 (45%), Positives = 171/258 (66%), Gaps = 2/258 (0%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHE 323 E+ RE + L +LG G FG V +G W G VA+K +K G+MS + F QEAQ M KL H Sbjct: 4 ELKREEITLLKELGSGQFGVVKLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHP 63 Query: 324 KLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 KLV+ Y V S+E PIYIVTEY+S G LL++L+ GK L QL++M + GMA++E Sbjct: 64 KLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSH-GKGLEPSQLLEMCYDVCEGMAFLES 122 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 ++HRDL A N LV +L KV+DFG+ R + D++Y + G KFP+KW+APE Y ++ Sbjct: 123 HQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKY 182 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCW 502 + KSDVW+FGIL+ E+ + G++PY N EV+ +V +G+R+ P ++++ +M CW Sbjct: 183 SSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQIMYSCW 242 Query: 503 RKEPEERPTFEYLQAFLE 520 + PE+RPTF+ L + +E Sbjct: 243 HELPEKRPTFQQLLSSIE 260 >6E4F-A nrPDB Length = 290 Score = 237 bits (605), Expect = 8e-63, Method: Compositional matrix adjust. Identities = 113/268 (42%), Positives = 172/268 (64%), Gaps = 2/268 (0%) Query: 255 TQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEA 314 T GL +WEI + L +LG G FG V G W G VAIK +K G+MS + F++EA Sbjct: 18 TAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEA 77 Query: 315 QVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373 +VM L HEKLVQLY V +++ PI+I+TEYM+ G LL++L+ E + QL++M + Sbjct: 78 KVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLR-EMRHRFQTQQLLEMCKDV 136 Query: 374 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 433 M Y+E ++HRDL A N LV + V KV+DFGL+R + D+EYT+ G+KFP++W+ Sbjct: 137 CEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSP 196 Query: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES 493 PE +Y +F+ KSD+W+FG+L+ E+ + G++PY N E + + +G R+ P E Sbjct: 197 PEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEK 256 Query: 494 LHDLMCQCWRKEPEERPTFEYLQAFLED 521 ++ +M CW ++ +ERPTF+ L + + D Sbjct: 257 VYTIMYSCWHEKADERPTFKILLSNILD 284 >4E93-A nrPDB Length = 377 Score = 231 bits (590), Expect = 5e-61, Method: Compositional matrix adjust. Identities = 149/377 (39%), Positives = 213/377 (56%), Gaps = 34/377 (9%) Query: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205 + + WY G I R E LL+++ G FLVRES+ K Y LSV +D +H+ Sbjct: 10 LHEQLWYHGAIPRAEVAELLVHS----GDFLVRESQG-KQEYVLSVL-WDGLP----RHF 59 Query: 206 KIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQ----TQGLAKD 261 I+ LD+ Y F S+ L+ H L+T P +K + + KD Sbjct: 60 IIQSLDN--LYRLEGEGFPSIPLLID----------HLLSTQQPLTKKSGVVLHRAVPKD 107 Query: 262 AWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPE---AFLQEAQVM 317 W + E L L ++G+G FGEV+ G T VA+K+ + T+ P+ FLQEA+++ Sbjct: 108 KWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARIL 166 Query: 318 KKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 K+ H +V+L V ++ +PIYIV E + G L FL+ E G LR+ L+ M A+G Sbjct: 167 KQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE-GARLRVKTLLQMVGDAAAG 225 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK-FPIKWTAPE 435 M Y+E +HRDL A N LV E V K++DFG++R D Y A G + P+KWTAPE Sbjct: 226 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPE 285 Query: 436 AALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLH 495 A YGR++ +SDVWSFGILL E + G PYP + N++ + VE+G R+PCP CP+++ Sbjct: 286 ALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVF 345 Query: 496 DLMCQCWRKEPEERPTF 512 LM QCW EP +RP+F Sbjct: 346 RLMEQCWAYEPGQRPSF 362 >2Y6O-A nrPDB Length = 291 Score = 229 bits (583), Expect = 3e-60, Method: Compositional matrix adjust. Identities = 124/276 (44%), Positives = 171/276 (61%), Gaps = 12/276 (4%) Query: 255 TQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----VAIKTLKPGTMSPEA- 309 Q + + A EI +++E +G G FGEV G + VAIKTLK G + Sbjct: 1 NQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRR 60 Query: 310 -FLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLV 367 FL EA +M + H ++ L VV++ +P+ I+TEYM GSL FL+ G++ + QLV Sbjct: 61 DFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVI-QLV 119 Query: 368 DMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDN---EYTARQG 424 M I SGM Y+ M+YVHRDL A NILV NLVCKV+DFG++R++ED+ YT R G Sbjct: 120 GMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTR-G 178 Query: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484 K PI+WTAPEA Y +FT SDVWS+GI++ E+ + G PY M N++V+ +E GYR+ Sbjct: 179 GKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRL 238 Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 P P +CP +LH LM CW+KE +RP F + L+ Sbjct: 239 PPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLD 274 >3QGY-A nrPDB Length = 286 Score = 228 bits (582), Expect = 4e-60, Method: Compositional matrix adjust. Identities = 111/261 (42%), Positives = 164/261 (62%), Gaps = 11/261 (4%) Query: 265 IPRESLRLEV---------KLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQ 315 +PR SL + + ++G G FG V +G W +VAIKT+K G+MS + F++EA+ Sbjct: 15 VPRGSLHMVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIKEGSMSEDDFIEEAE 74 Query: 316 VMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 374 VM KL H KLVQLY V E+ PI +V E+M G L D+L+ + G + L+ M + Sbjct: 75 VMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAA-ETLLGMCLDVC 133 Query: 375 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 434 GMAY+E +HRDL A N LVGEN V KV+DFG+ R + D++YT+ G KFP+KW +P Sbjct: 134 EGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASP 193 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESL 494 E + R++ KSDVWSFG+L+ E+ ++G++PY N EV++ + G+R+ P + Sbjct: 194 EVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHV 253 Query: 495 HDLMCQCWRKEPEERPTFEYL 515 + +M CW++ PE+RP F L Sbjct: 254 YQIMNHCWKERPEDRPAFSRL 274 >1JPA-A nrPDB Length = 312 Score = 228 bits (581), Expect = 5e-60, Method: Compositional matrix adjust. Identities = 120/262 (45%), Positives = 164/262 (62%), Gaps = 12/262 (4%) Query: 262 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----VAIKTLKPGTMSPE--AFLQEAQ 315 A EI +++E +G G FGEV G + VAIKTLK G + FL EA Sbjct: 27 AKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEAS 86 Query: 316 VMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 374 +M + H ++ L VV++ P+ I+TE+M GSL FL+ G++ + QLV M IA Sbjct: 87 IMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVI-QLVGMLRGIA 145 Query: 375 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE----YTARQGAKFPIK 430 +GM Y+ MNYVHRDL A NILV NLVCKV+DFGL+R +ED+ YT+ G K PI+ Sbjct: 146 AGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIR 205 Query: 431 WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC 490 WTAPEA Y +FT SDVWS+GI++ E+ + G PY M N++V++ +E+ YR+P P +C Sbjct: 206 WTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDC 265 Query: 491 PESLHDLMCQCWRKEPEERPTF 512 P +LH LM CW+K+ RP F Sbjct: 266 PSALHQLMLDCWQKDRNHRPKF 287 >4P5Q-A nrPDB Length = 361 Score = 226 bits (577), Expect = 2e-59, Method: Compositional matrix adjust. Identities = 123/276 (44%), Positives = 174/276 (63%), Gaps = 12/276 (4%) Query: 255 TQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----VAIKTLKPGTMSPE-- 308 TQ + + A E+ ++ ++ +G G FGEV G ++ VAIKTLK G + Sbjct: 20 TQTVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQRR 79 Query: 309 AFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLV 367 FL EA +M + H +++L VV++ +P+ IVTEYM GSL FL+ ++ + QLV Sbjct: 80 DFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQFTVI-QLV 138 Query: 368 DMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDN---EYTARQG 424 M IASGM Y+ M YVHRDL A NIL+ NLVCKV+DFGL+R++ED+ YT R G Sbjct: 139 GMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTR-G 197 Query: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484 K PI+WT+PEA Y +FT SDVWS+GI+L E+ + G PY M N++V+ V+ GYR+ Sbjct: 198 GKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRL 257 Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 P P +CP +L+ LM CW+K+ RP FE + + L+ Sbjct: 258 PPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILD 293 >2R2P-A nrPDB Length = 295 Score = 225 bits (574), Expect = 3e-59, Method: Compositional matrix adjust. Identities = 125/281 (44%), Positives = 172/281 (61%), Gaps = 12/281 (4%) Query: 250 TSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----VAIKTLKPGTM 305 T + Q + + A EI + +E +G G FGEV G + VAIKTLK G Sbjct: 4 TYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYT 63 Query: 306 SPE--AFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLR 362 + FL EA +M + H ++ L VV++ +P+ IVTEYM GSL FLK G++ Sbjct: 64 EKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTV 123 Query: 363 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDN---EY 419 + QLV M I++GM Y+ M YVHRDL A NIL+ NLVCKV+DFGL+R++ED+ Y Sbjct: 124 I-QLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAY 182 Query: 420 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE 479 T R G K PI+WTAPEA + +FT SDVWS+GI++ E+ + G PY M N++V+ VE Sbjct: 183 TTR-GGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVE 241 Query: 480 RGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 GYR+P P +CP +L+ LM CW+KE RP F+ + L+ Sbjct: 242 EGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLD 282 >4PDO-A nrPDB Length = 299 Score = 224 bits (570), Expect = 1e-58, Method: Compositional matrix adjust. Identities = 122/277 (44%), Positives = 171/277 (61%), Gaps = 13/277 (4%) Query: 255 TQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-----VAIKTLKPGTMSPEA 309 Q + K EI + + +G G FGEV+ G ++ VAIKTLK G + Sbjct: 21 NQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQR 80 Query: 310 --FLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQL 366 FL EA +M + H +++L V+S+ +P+ I+TEYM G+L FL+ + G++ L QL Sbjct: 81 VDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGEFSVL-QL 139 Query: 367 VDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDN---EYTARQ 423 V M IA+GM Y+ MNYVHRDL A NILV NLVCKV+DFGL+R++ED+ YT Sbjct: 140 VGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTT-S 198 Query: 424 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 483 G K PI+WTAPEA Y +FT SDVWSFGI++ E+ T G PY + N EV+ + G+R Sbjct: 199 GGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFR 258 Query: 484 MPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 +P P +CP +++ LM QCW++E RP F + + L+ Sbjct: 259 LPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILD 295 >3DKO-A nrPDB Length = 318 Score = 223 bits (569), Expect = 1e-58, Method: Compositional matrix adjust. Identities = 123/269 (45%), Positives = 164/269 (60%), Gaps = 12/269 (4%) Query: 262 AWEIPRESLRLEVKLGQGCFGEVWMGTWN----GTTRVAIKTLKPGTMSPE--AFLQEAQ 315 A E+ +++E +G G FGEV G VAIKTLK G + FL EA Sbjct: 37 AKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEAS 96 Query: 316 VMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 374 +M + H +V L VV+ +P+ IV E+M G+L FL+ G++ + QLV M IA Sbjct: 97 IMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVI-QLVGMLRGIA 155 Query: 375 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE---YTARQGAKFPIKW 431 +GM Y+ M YVHRDL A NILV NLVCKV+DFGL+R+IED+ YT G K P++W Sbjct: 156 AGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTT-TGGKIPVRW 214 Query: 432 TAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP 491 TAPEA Y +FT SDVWS+GI++ E+ + G PY M N++V+ +E GYR+P P +CP Sbjct: 215 TAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCP 274 Query: 492 ESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 LH LM CW+KE ERP FE + L+ Sbjct: 275 AGLHQLMLDCWQKERAERPKFEQIVGILD 303 >5MJB-A nrPDB Length = 305 Score = 223 bits (567), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 116/262 (44%), Positives = 165/262 (62%), Gaps = 12/262 (4%) Query: 262 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----VAIKTLKPGTMSPE--AFLQEAQ 315 A EI +++E +G G FGEV+ G + VAIKTLK G + FL EA Sbjct: 20 AKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEAS 79 Query: 316 VMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 374 +M + H +++L VV++ P+ I+TE+M +L FL+ G++ + QLV M IA Sbjct: 80 IMGQFDHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQFTVI-QLVGMLRGIA 138 Query: 375 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE----YTARQGAKFPIK 430 +GM Y+ MNYVHRDL A NILV NLVCKV+DFGL+R ++D+ YT+ G K P++ Sbjct: 139 AGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVR 198 Query: 431 WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC 490 WTAPEA Y +FT SDVWS+GI++ E+ + G PY M N++V++ +E+ YR+P P +C Sbjct: 199 WTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDC 258 Query: 491 PESLHDLMCQCWRKEPEERPTF 512 P +LH LM CW+K+ RP F Sbjct: 259 PAALHQLMLDCWQKDRNSRPRF 280 >2VWV-A nrPDB Length = 302 Score = 222 bits (565), Expect = 4e-58, Method: Compositional matrix adjust. Identities = 119/270 (44%), Positives = 167/270 (61%), Gaps = 12/270 (4%) Query: 262 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----VAIKTLKPGTMSPE--AFLQEAQ 315 A EI +++E +G G FGEV G + VAIKTLK G + FL EA Sbjct: 10 AKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEAS 69 Query: 316 VMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 374 +M + H +++L VV+ P+ I+TE+M G+L FL+ G++ + QLV M IA Sbjct: 70 IMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVI-QLVGMLRGIA 128 Query: 375 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEY----TARQGAKFPIK 430 SGM Y+ M+YVHRDL A NILV NLVCKV+DFGL+R +E+N T+ G K PI+ Sbjct: 129 SGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIR 188 Query: 431 WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC 490 WTAPEA + +FT SD WS+GI++ E+ + G PY M N++V++ +E+ YR+P PP+C Sbjct: 189 WTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDC 248 Query: 491 PESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 P SLH LM CW+K+ RP F + + L+ Sbjct: 249 PTSLHQLMLDCWQKDRNARPRFPQVVSALD 278 >5L6P-A nrPDB Length = 298 Score = 221 bits (564), Expect = 5e-58, Method: Compositional matrix adjust. Identities = 120/270 (44%), Positives = 166/270 (61%), Gaps = 12/270 (4%) Query: 262 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----VAIKTLKPGTMSPEA--FLQEAQ 315 A EI +++E +G G FGEV G R VAIKTLK G + FL EA Sbjct: 13 AKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTERQRRDFLSEAS 72 Query: 316 VMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 374 +M + H +++L VV++ P+ I+TE+M +L FL+ G++ + QLV M IA Sbjct: 73 IMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVI-QLVGMLRGIA 131 Query: 375 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDN----EYTARQGAKFPIK 430 +GM Y+ MNYVHRDL A NILV NLVCKV+DFGL+R +ED+ YT+ G K PI+ Sbjct: 132 AGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIR 191 Query: 431 WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC 490 WTAPEA Y +FT SDVWS+GI++ E+ + G PY M N++V++ VE+ YR+P P +C Sbjct: 192 WTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDC 251 Query: 491 PESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 P +LH LM CW ++ RP F + L+ Sbjct: 252 PTALHQLMLDCWVRDRNLRPKFSQIVNTLD 281 >1BYG-A nrPDB Length = 278 Score = 216 bits (549), Expect = 3e-56, Method: Compositional matrix adjust. Identities = 114/263 (43%), Positives = 165/263 (62%), Gaps = 8/263 (3%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKK 319 + W + + L+L +G+G FG+V +G + G +VA+K +K + +AFL EA VM + Sbjct: 13 RSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEASVMTQ 70 Query: 320 LRHEKLVQLYAVVSEEP--IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 LRH LVQL V+ EE +YIVTEYM+KGSL+D+L+ L L+ + + M Sbjct: 71 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 130 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 437 Y+E N+VHRDL A N+LV E+ V KV+DFGL + + T K P+KWTAPEA Sbjct: 131 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEAL 186 Query: 438 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDL 497 +F+ KSDVWSFGILL E+ + GRVPYP + ++V+ +VE+GY+M P CP +++++ Sbjct: 187 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEV 246 Query: 498 MCQCWRKEPEERPTFEYLQAFLE 520 M CW + RP+F L+ LE Sbjct: 247 MKNCWHLDAAMRPSFLQLREQLE 269 >3KUL-B nrPDB Length = 325 Score = 212 bits (539), Expect = 4e-55, Method: Compositional matrix adjust. Identities = 116/273 (42%), Positives = 158/273 (57%), Gaps = 10/273 (3%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----VAIKTLKPGTMSPEA--FLQEAQVM 317 EI + +E +G G GEV G + VAIK LK G + FL EA +M Sbjct: 45 EIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIM 104 Query: 318 KKLRHEKLVQLYAVVSEEPI-YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 + H +++L VV+ + IVTEYM GSL FL+ G++ + QLV M + +G Sbjct: 105 GQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQFT-IMQLVGMLRGVGAG 163 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA--RQGAKFPIKWTAP 434 M Y+ + YVHRDL A N+LV NLVCKV+DFGL+R++ED+ A G K PI+WTAP Sbjct: 164 MRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAP 223 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESL 494 EA + F+ SDVWSFG+++ E+ G PY M NR+V+ VE GYR+P P CP +L Sbjct: 224 EAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHAL 283 Query: 495 HDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE 527 H LM CW K+ +RP F + + L+ S E Sbjct: 284 HQLMLDCWHKDRAQRPRFSQIVSVLDALIRSPE 316 >2OZO-A nrPDB Length = 613 Score = 209 bits (531), Expect = 3e-54, Method: Compositional matrix adjust. Identities = 142/455 (31%), Positives = 220/455 (48%), Gaps = 76/455 (16%) Query: 151 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 210 WY +TR E+ER L + G FL+R + +G Y LS+ G V HY I + Sbjct: 163 WYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSL-----IYGKTVYHYLISQD 216 Query: 211 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC-------------PT------- 250 +G + I T+F++L QLV Y ADGL + L C PT Sbjct: 217 KAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPAHPST 276 Query: 251 --------------------------SKPQTQGLAKDAWEIP---------------RES 269 KP+ + +E P R++ Sbjct: 277 LTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVFESPFSDPEELKDKKLFLKRDN 336 Query: 270 LRL-EVKLGQGCFGEVWMGTWNGTTR---VAIKTLKPGT--MSPEAFLQEAQVMKKLRHE 323 L + +++LG G FG V G + + VAIK LK GT E ++EAQ+M +L + Sbjct: 337 LLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNP 396 Query: 324 KLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 +V+L V E + +V E G L FL G+ + + + + ++ Q++ GM Y+E Sbjct: 397 YIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSMGMKYLEEK 455 Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGR 441 N+VHR+L A N+L+ K++DFGL++ + +D+ YTAR K+P+KW APE + + Sbjct: 456 NFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRK 515 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 501 F+ +SDVWS+G+ + E + G+ PY M EV+ +E+G RM CPPECP L+ LM C Sbjct: 516 FSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDC 575 Query: 502 WRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536 W + E+RP F ++ + + S + + G L Sbjct: 576 WIYKWEDRPDFLTVEQRMRACYYSLASKVEGGSAL 610 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 27/98 (27%), Positives = 44/98 (44%), Gaps = 5/98 (5%) Query: 151 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 210 +++G I+R E+E L A G FL+R+ + G Y LS+ + H+ I + Sbjct: 10 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSL-----VHDVRFHHFPIERQ 64 Query: 211 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC 248 +G + I +L +YS+ DGL L C Sbjct: 65 LNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC 102 >4EBW-A nrPDB Length = 304 Score = 206 bits (525), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 111/280 (39%), Positives = 160/280 (57%), Gaps = 9/280 (3%) Query: 257 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTW----NGTTRVAIKTLKPGTMSP--EAF 310 G + +EI RE + L +G+G FG+V G + N VAIKT K T E F Sbjct: 27 GSSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKF 86 Query: 311 LQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY-LRLPQLVDM 369 LQEA M++ H +V+L V++E P++I+ E + G L FL + KY L L L+ Sbjct: 87 LQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFL--QVRKYSLDLASLILY 144 Query: 370 AAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 429 A Q+++ +AY+E +VHRD+ A N+LV N K+ DFGL+R +ED+ Y K PI Sbjct: 145 AYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPI 204 Query: 430 KWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE 489 KW APE+ + RFT SDVW FG+ + E+ G P+ G+ N +V+ ++E G R+P PP Sbjct: 205 KWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPN 264 Query: 490 CPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 CP +L+ LM +CW +P RP F L+A L + Q Sbjct: 265 CPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQ 304 >2J0K-A nrPDB Length = 656 Score = 203 bits (516), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 107/264 (40%), Positives = 155/264 (58%), Gaps = 9/264 (3%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTW----NGTTRVAIKTLKPGTMSP--EAFLQEAQV 316 +EI RE + L +G+G FG+V G + N VAIKT K T E FLQEA Sbjct: 385 YEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALT 444 Query: 317 MKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY-LRLPQLVDMAAQIAS 375 M++ H +V+L V++E P++I+ E + G L FL + K+ L L L+ A Q+++ Sbjct: 445 MRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFL--QVRKFSLDLASLILYAYQLST 502 Query: 376 GMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPE 435 +AY+E +VHRD+ A N+LV K+ DFGL+R +ED+ Y K PIKW APE Sbjct: 503 ALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPE 562 Query: 436 AALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLH 495 + + RFT SDVW FG+ + E+ G P+ G+ N +V+ ++E G R+P PP CP +L+ Sbjct: 563 SINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLY 622 Query: 496 DLMCQCWRKEPEERPTFEYLQAFL 519 LM +CW +P RP F L+A L Sbjct: 623 SLMTKCWAYDPSRRPRFTELKAQL 646 >3ZBF-A nrPDB Length = 322 Score = 203 bits (516), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 120/286 (41%), Positives = 166/286 (58%), Gaps = 21/286 (7%) Query: 256 QGLAKDAWEIPRESLRLEVKLGQGCFGEVW-------MGTWNGTTRVAIKTLKPGTMSPE 308 QG ++ PRE L L + LG G FGEV+ +G +G +VA+KTLK G+ E Sbjct: 21 QGSIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQE 80 Query: 309 A--FLQEAQVMKKLRHEKLV-QLYAVVSEEPIYIVTEYMSKGSLLDFLKGET-----GKY 360 FL+EA +M K H ++ QL + EP YI+ E M G LL +L+ G Sbjct: 81 KIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPL 140 Query: 361 LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGEN-----LVCKVADFGLARLIE 415 L L LVD+ I+ G Y+ERM+++HRDL A N LV + K+ DFGLAR I Sbjct: 141 LTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIY 200 Query: 416 DNEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREV 474 N+Y ++G P++W APE+ + G FT +SDVWSFGIL+ E+ T G PYP N +V Sbjct: 201 KNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDV 260 Query: 475 LDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 L+ V+ G R+ P CP+ L +LM QCW +EP++RPTF +Q L+ Sbjct: 261 LNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ 306 >4HZS-A nrPDB Length = 341 Score = 198 bits (504), Expect = 5e-51, Method: Compositional matrix adjust. Identities = 108/266 (40%), Positives = 155/266 (58%), Gaps = 12/266 (4%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNG----TTRVAIKTLKPGTMS-PEA---FLQEAQV 316 I + LRL KLG G FG V G W+ T VA+K LKP +S PEA F++E Sbjct: 9 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 68 Query: 317 MKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 M L H L++LY VV P+ +VTE GSLLD L+ G +L L L A Q+A G Sbjct: 69 MHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQVAEG 127 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAP 434 M Y+E ++HRDL A N+L+ + K+ DFGL R + D+ Y ++ K P W AP Sbjct: 128 MGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 187 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER-GYRMPCPPECPES 493 E+ F+ SD W FG+ L E+ T G+ P+ G+ ++L ++++ G R+P P +CP+ Sbjct: 188 ESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 247 Query: 494 LHDLMCQCWRKEPEERPTFEYLQAFL 519 ++++M QCW +PE+RPTF L+ FL Sbjct: 248 IYNVMVQCWAHKPEDRPTFVALRDFL 273 >1U54-B nrPDB Length = 291 Score = 198 bits (503), Expect = 6e-51, Method: Compositional matrix adjust. Identities = 108/266 (40%), Positives = 155/266 (58%), Gaps = 12/266 (4%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNG----TTRVAIKTLKPGTMS-PEA---FLQEAQV 316 I + LRL KLG G FG V G W+ T VA+K LKP +S PEA F++E Sbjct: 15 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 74 Query: 317 MKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 M L H L++LY VV P+ +VTE GSLLD L+ G +L L L A Q+A G Sbjct: 75 MHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQVAEG 133 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAP 434 M Y+E ++HRDL A N+L+ + K+ DFGL R + D+ Y ++ K P W AP Sbjct: 134 MGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 193 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER-GYRMPCPPECPES 493 E+ F+ SD W FG+ L E+ T G+ P+ G+ ++L ++++ G R+P P +CP+ Sbjct: 194 ESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 253 Query: 494 LHDLMCQCWRKEPEERPTFEYLQAFL 519 ++++M QCW +PE+RPTF L+ FL Sbjct: 254 IYNVMVQCWAHKPEDRPTFVALRDFL 279 >4XCU-A nrPDB Length = 300 Score = 198 bits (503), Expect = 6e-51, Method: Compositional matrix adjust. Identities = 112/282 (39%), Positives = 158/282 (56%), Gaps = 18/282 (6%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNG--------TTRVAIKTLKPGTMSPEA--FLQ 312 WE PR+ L L LG+GCFG+V G + VA+K LK + + Sbjct: 12 WEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVS 71 Query: 313 EAQVMKKL-RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLK-----GETGKYLRLPQ 365 E +VMK + RH+ ++ L V ++E P+Y++ E +KG+L +FL+ G + L P Sbjct: 72 EMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPV 131 Query: 366 LVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTAR-QG 424 LV A Q+A GM Y+E +HRDL A N+LV E+ V K+ADFGLAR + +Y + Sbjct: 132 LVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSN 191 Query: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484 + P+KW APEA +T +SDVWSFGILL E+ T G PYPG+ E+ + G+RM Sbjct: 192 GRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRM 251 Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 PP CP L+ LM +CW P +RPTF+ L L+ + Sbjct: 252 DRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAV 293 >2OGV-A nrPDB Length = 317 Score = 196 bits (497), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 108/297 (36%), Positives = 168/297 (56%), Gaps = 25/297 (8%) Query: 245 TTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVW------MGTWNGTTRVAIK 298 T + PT P + WE PR +L+ LG G FG+V +G + +VA+K Sbjct: 20 TFIDPTQLPYNE-----KWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVK 74 Query: 299 TLKPGTMS--PEAFLQEAQVMKKL-RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLK 354 LK + EA + E ++M L +HE +V L + P+ ++TEY G LL+FL+ Sbjct: 75 MLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLR 134 Query: 355 --------GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVA 406 E G+ L L L+ ++Q+A GMA++ N +HRD+ A N+L+ V K+ Sbjct: 135 RKAEADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIG 194 Query: 407 DFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 465 DFGLAR ++ D+ Y + A+ P+KW APE+ +T++SDVWS+GILL E+ + G P Sbjct: 195 DFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNP 254 Query: 466 YPG-MVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLED 521 YPG +VN + V+ GY+M P P++++ +M CW EP RPTF+ + +FL++ Sbjct: 255 YPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQE 311 >4R7H-A nrPDB Length = 343 Score = 193 bits (491), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 108/310 (34%), Positives = 169/310 (54%), Gaps = 38/310 (12%) Query: 245 TTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVW------MGTWNGTTRVAIK 298 T + PT P + WE PR +L+ LG G FG+V +G + +VA+K Sbjct: 32 TFIDPTQLPYNE-----KWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVK 86 Query: 299 TLKPGTMS--PEAFLQEAQVMKKL-RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLK 354 LK + EA + E ++M L +HE +V L + P+ ++TEY + G LL+FL+ Sbjct: 87 MLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCTYGDLLNFLR 146 Query: 355 ---------------------GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAA 393 E G+ L L L+ ++Q+A GMA++ N +HRD+ A Sbjct: 147 RKAEAMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAAR 206 Query: 394 NILVGENLVCKVADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFG 452 N+L+ V K+ DFGLAR ++ D+ Y + A+ P+KW APE+ +T++SDVWS+G Sbjct: 207 NVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDSVYTVQSDVWSYG 266 Query: 453 ILLTELTTKGRVPYPG-MVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPT 511 ILL E+ + G PYPG +VN + V+ GY+M P P++++ +M CW EP RPT Sbjct: 267 ILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPT 326 Query: 512 FEYLQAFLED 521 F+ + +FL++ Sbjct: 327 FQQITSFLQE 336 >4H1J-A nrPDB Length = 293 Score = 189 bits (480), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 101/265 (38%), Positives = 148/265 (55%), Gaps = 7/265 (2%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNG----TTRVAIKTLKPGTM--SPEAFLQEAQVMK 318 I RE + L LG+G FGEV+ G + VA+KT K + E F+ EA +MK Sbjct: 21 IAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMK 80 Query: 319 KLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378 L H +V+L ++ EEP +I+ E G L +L+ L++ LV + QI MA Sbjct: 81 NLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNS-LKVLTLVLYSLQICKAMA 139 Query: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438 Y+E +N VHRD+ NILV K+ DFGL+R IED +Y + PIKW +PE+ Sbjct: 140 YLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESIN 199 Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM 498 + RFT SDVW F + + E+ + G+ P+ + N++V+ +E+G R+P P CP L+ LM Sbjct: 200 FRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLM 259 Query: 499 CQCWRKEPEERPTFEYLQAFLEDYF 523 +CW +P +RP F L L D + Sbjct: 260 TRCWDYDPSDRPRFTELVCSLSDVY 284 >3BEA-A nrPDB Length = 333 Score = 189 bits (479), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 105/301 (34%), Positives = 166/301 (55%), Gaps = 29/301 (9%) Query: 245 TTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVW------MGTWNGTTRVAIK 298 T + PT P + WE PR +L+ LG G FG+V +G + +VA+K Sbjct: 28 TFIDPTQLPYNE-----KWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVK 82 Query: 299 TLKPGTMS--PEAFLQEAQVMKKL-RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLK 354 LK + EA + E ++M L +HE +V L + P+ ++TEY G LL+FL+ Sbjct: 83 MLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLR 142 Query: 355 GET------------GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLV 402 ++ L L+ ++Q+A GMA++ N +HRD+ A N+L+ V Sbjct: 143 RKSRVLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHV 202 Query: 403 CKVADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTK 461 K+ DFGLAR ++ D+ Y + A+ P+KW APE+ +T++SDVWS+GILL E+ + Sbjct: 203 AKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSL 262 Query: 462 GRVPYPG-MVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 G PYPG +VN + V+ GY+M P P++++ +M CW EP RPTF+ + +FL+ Sbjct: 263 GLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQ 322 Query: 521 D 521 + Sbjct: 323 E 323 >3I81-A nrPDB Length = 315 Score = 189 bits (479), Expect = 3e-48, Method: Compositional matrix adjust. Identities = 110/292 (37%), Positives = 160/292 (54%), Gaps = 27/292 (9%) Query: 261 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT------TRVAIKTLKPGTMSPE--AFLQ 312 D WE+ RE + + +LGQG FG V+ G G TRVAIKT+ E FL Sbjct: 11 DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLN 70 Query: 313 EAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKG-----ETGKYL---RL 363 EA VMK+ +V+L VVS+ +P ++ E M++G L +L+ E L L Sbjct: 71 EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSL 130 Query: 364 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 423 +++ MA +IA GMAY+ +VHRDL A N +V E+ K+ DFG+ R I + +Y R+ Sbjct: 131 SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYY-RK 189 Query: 424 GAK--FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481 G K P++W +PE+ G FT SDVWSFG++L E+ T PY G+ N +VL V G Sbjct: 190 GGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEG 249 Query: 482 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPG 533 + P CP+ L +LM CW+ P+ RP+F + +S + + +PG Sbjct: 250 GLLDKPDNCPDMLFELMRMCWQYNPKMRPSF-------LEIISSIKEEMEPG 294 >5AMN-A nrPDB Length = 299 Score = 188 bits (478), Expect = 5e-48, Method: Compositional matrix adjust. Identities = 106/276 (38%), Positives = 154/276 (55%), Gaps = 18/276 (6%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTW------NGTTRVAIKTLKPGTMSPEA--FLQEA 314 WE PR++L L LG+G FG+V T G T VA+K LK E L E Sbjct: 18 WEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEF 77 Query: 315 QVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETG--------KYLRLPQ 365 V+K++ H +++LY S++ P+ ++ EY GSL FL+ + L + Sbjct: 78 NVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGD 137 Query: 366 LVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR-LIEDNEYTARQG 424 L+ A QI+ GM Y+ M VHRDL A NILV E K++DFGL+R + E++ Y R Sbjct: 138 LISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQ 197 Query: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484 + P+KW A E+ +T +SDVWSFG+LL E+ T G PYPG+ + + ++ G+RM Sbjct: 198 GRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRM 257 Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 P C E ++ LM QCW++EP++RP F + LE Sbjct: 258 ERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLE 293 >6GQK-A nrPDB Length = 328 Score = 188 bits (477), Expect = 6e-48, Method: Compositional matrix adjust. Identities = 105/284 (36%), Positives = 153/284 (53%), Gaps = 26/284 (9%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR------VAIKTLKPGTMSPE--AFLQEA 314 WE PR L LG G FG+V T G + VA+K LKP S E A + E Sbjct: 36 WEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSEL 95 Query: 315 QVMKKL-RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKY------------ 360 +V+ L HE +V L + P ++TEY G LL+FL+ + ++ Sbjct: 96 KVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYK 155 Query: 361 --LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DN 417 L L L+ + Q+A GMA++ N +HRDL A NIL+ + K+ DFGLAR I+ D+ Sbjct: 156 DFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDS 215 Query: 418 EYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLD 476 Y + A+ P+KW APE+ +T +SDVWS+GI L EL + G PYPGM V+ + Sbjct: 216 NYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYK 275 Query: 477 QVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 ++ G+RM P P ++D+M CW +P++RPTF+ + +E Sbjct: 276 MIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQDIE 319 >5GRN-A nrPDB Length = 356 Score = 187 bits (475), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 106/295 (35%), Positives = 156/295 (52%), Gaps = 36/295 (12%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR------VAIKTLKPGTMSPE--AFLQEA 314 WE PR+ L L LG G FG+V GT G +R VA+K LKP S E A + E Sbjct: 41 WEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSEL 100 Query: 315 QVMKKLR-HEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLR---------- 362 ++M L H +V L ++ PIYI+TEY G L+++L +L Sbjct: 101 KIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLDSE 160 Query: 363 --------------LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADF 408 L L+ Q+A GM ++ N VHRDL A N+L+ + + K+ DF Sbjct: 161 VKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDF 220 Query: 409 GLAR-LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYP 467 GLAR ++ D+ Y ++ P+KW APE+ +T SDVWS+GILL E+ + G PYP Sbjct: 221 GLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYP 280 Query: 468 G-MVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLED 521 G MV+ ++++ GYRM P ++++M +CW EPE+RP+F +L +E+ Sbjct: 281 GMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVEN 335 >4XLV-A nrPDB Length = 328 Score = 187 bits (474), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 110/288 (38%), Positives = 155/288 (53%), Gaps = 20/288 (6%) Query: 261 DAWEIPRESLRLEVKLGQGCFGEVWMGTW------NGTTRVAIKTLKPGTMSPE--AFLQ 312 D WE+ RE + L +LGQG FG V+ G TRVA+KT+ E FL Sbjct: 32 DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLN 91 Query: 313 EAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLP------- 364 EA VMK +V+L VVS+ +P +V E M+ G L +L+ + P Sbjct: 92 EASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTL 151 Query: 365 -QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 423 +++ MAA+IA GMAY+ +VHRDL A N +V + K+ DFG+ R I + +Y R+ Sbjct: 152 QEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYY-RK 210 Query: 424 GAK--FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481 G K P++W APE+ G FT SD+WSFG++L E+T+ PY G+ N +VL V G Sbjct: 211 GGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDG 270 Query: 482 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 + P CPE + DLM CW+ P RPTF + L+D + P+ Sbjct: 271 GYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSFPE 318 >3KRL-A nrPDB Length = 335 Score = 186 bits (471), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 107/303 (35%), Positives = 166/303 (54%), Gaps = 31/303 (10%) Query: 245 TTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVW------MGTWNGTTRVAIK 298 T + PT P + WE PR +L+ LG G FG+V +G + +VA+K Sbjct: 28 TFIDPTQLPYNE-----KWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVK 82 Query: 299 TLKPGTMS--PEAFLQEAQVMKKL-RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLK 354 LK + EA + E ++M L +HE +V L + P+ ++TEY G LL+FL+ Sbjct: 83 MLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLR 142 Query: 355 -----GETGKY---------LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGEN 400 G Y L L+ ++Q+A GMA++ N +HRD+ A N+L+ Sbjct: 143 RKRPPGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNG 202 Query: 401 LVCKVADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELT 459 V K+ DFGLAR ++ D+ Y + A+ P+KW APE+ +T++SDVWS+GILL E+ Sbjct: 203 HVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIF 262 Query: 460 TKGRVPYPG-MVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAF 518 + G PYPG +VN + V+ GY+M P P++++ +M CW EP RPTF+ + +F Sbjct: 263 SLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSF 322 Query: 519 LED 521 L++ Sbjct: 323 LQE 325 >2PSQ-A nrPDB Length = 370 Score = 184 bits (468), Expect = 6e-47, Method: Compositional matrix adjust. Identities = 106/291 (36%), Positives = 158/291 (54%), Gaps = 27/291 (9%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR--------VAIKTLKPGTMSPEA--FLQ 312 WE PR+ L L LG+GCFG+V M G + VA+K LK + + Sbjct: 76 WEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVS 135 Query: 313 EAQVMKKL-RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYL-------RL 363 E ++MK + +H+ ++ L +++ P+Y++ EY SKG+L ++L+ + R+ Sbjct: 136 EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRV 195 Query: 364 PQ-------LVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED 416 P+ LV Q+A GM Y+ +HRDL A N+LV EN V K+ADFGLAR I + Sbjct: 196 PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINN 255 Query: 417 NEYTARQ-GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVL 475 +Y + + P+KW APEA +T +SDVWSFG+L+ E+ T G PYPG+ E+ Sbjct: 256 IDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF 315 Query: 476 DQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 ++ G+RM P C L+ +M CW P +RPTF+ L L+ T T Sbjct: 316 KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT 366 >5FM2-A nrPDB Length = 355 Score = 184 bits (466), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 106/290 (36%), Positives = 154/290 (53%), Gaps = 32/290 (11%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTW------NGTTRVAIKTLKPGTMSPEA--FLQEA 314 WE PR++L L LG+G FG+V T G T VA+K LK E L E Sbjct: 59 WEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEF 118 Query: 315 QVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETG--------------- 358 V+K++ H +++LY S++ P+ ++ EY GSL FL+ Sbjct: 119 NVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSS 178 Query: 359 -------KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLA 411 + L + L+ A QI+ GM Y+ M VHRDL A NILV E K++DFGL+ Sbjct: 179 SLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLS 238 Query: 412 R-LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMV 470 R + E++ Y R + P+KW A E+ +T +SDVWSFG+LL E+ T G PYPG+ Sbjct: 239 RDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIP 298 Query: 471 NREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 + + ++ G+RM P C E ++ LM QCW++EP++RP F + LE Sbjct: 299 PERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLE 348 >5A46-A nrPDB Length = 386 Score = 183 bits (465), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 106/294 (36%), Positives = 157/294 (53%), Gaps = 27/294 (9%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTW--------NGTTRVAIKTLKPGTMSPEA--FLQ 312 WE+PR+ L L LG+GCFG+V + N T+VA+K LK + + Sbjct: 35 WELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLIS 94 Query: 313 EAQVMKKL-RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKG--------------E 356 E ++MK + +H+ ++ L +++ P+Y++ EY SKG+L ++L+ Sbjct: 95 EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHN 154 Query: 357 TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED 416 + L LV A Q+A GM Y+ +HRDL A N+LV E+ V K+ADFGLAR I Sbjct: 155 PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHH 214 Query: 417 NEYTARQ-GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVL 475 +Y + + P+KW APEA +T +SDVWSFG+LL E+ T G PYPG+ E+ Sbjct: 215 IDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF 274 Query: 476 DQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 ++ G+RM P C L+ +M CW P +RPTF+ L L+ T Q Sbjct: 275 KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 328 >3V5Q-A nrPDB Length = 297 Score = 182 bits (461), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 100/284 (35%), Positives = 162/284 (57%), Gaps = 31/284 (10%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTT------RVAIKTLKPGTMSP-EAFLQEAQV 316 I R + L+ +LG+G FG+V++ + VA+K LK T++ + F +EA++ Sbjct: 11 HIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAEL 70 Query: 317 MKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFL------------------KGET 357 + L+HE +V+ Y V + +P+ +V EYM G L FL KGE Sbjct: 71 LTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGEL 130 Query: 358 GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDN 417 G L Q++ +A+QIASGM Y+ ++VHRDL N LVG NL+ K+ DFG++R + Sbjct: 131 G----LSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYST 186 Query: 418 EYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLD 476 +Y G PI+W PE+ +Y +FT +SDVWSFG++L E+ T G+ P+ + N EV++ Sbjct: 187 DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIE 246 Query: 477 QVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 + +G + P CP+ ++D+M CW++EP++R + + L Sbjct: 247 CITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILH 290 >6BSD-A nrPDB Length = 876 Score = 182 bits (461), Expect = 4e-46, Method: Compositional matrix adjust. Identities = 111/329 (33%), Positives = 165/329 (50%), Gaps = 47/329 (14%) Query: 245 TTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR---------- 294 T P P G + PR LR + KLG+G FGEV + + Sbjct: 548 TYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNV 607 Query: 295 -------VAIKTLKPGTM--SPEAFLQEAQVMKKLRHEKLVQLYAV-VSEEPIYIVTEYM 344 VA+K L+P + FL+E ++M +L+ +++L V V ++P+ ++T+YM Sbjct: 608 RKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYM 667 Query: 345 SKGSLLDFL-----------------KGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 G L FL + G + P L+ +AAQIASGM Y+ +N+VH Sbjct: 668 ENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVH 727 Query: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG-AKFPIKWTAPEAALYGRFTIKS 446 RDL N LVGEN K+ADFG++R + +Y QG A PI+W A E L G+FT S Sbjct: 728 RDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTAS 787 Query: 447 DVWSFGILLTELTTKGRV-PYPGMVNREVLDQVERGYR-------MPCPPECPESLHDLM 498 DVW+FG+ L E+ R P+ + + +V++ +R + PP CP+ L++LM Sbjct: 788 DVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELM 847 Query: 499 CQCWRKEPEERPTFEYLQAFL-EDYFTST 526 +CW +E E+RP F L FL ED + Sbjct: 848 LRCWSRESEQRPPFSQLHRFLAEDALNTV 876 >4AT3-A nrPDB Length = 299 Score = 180 bits (457), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 100/287 (34%), Positives = 163/287 (56%), Gaps = 21/287 (7%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMG-TWN-----GTTRVAIKTLKPGTMSP-EAFLQEAQV 316 I R ++ L+ +LG+G FG+V++ +N VA+KTLK + + + F +EA++ Sbjct: 9 HIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAEL 68 Query: 317 MKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLK-----------GETGKYLRLP 364 + L+HE +V+ Y V E +P+ +V EYM G L FL+ G L Sbjct: 69 LTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQS 128 Query: 365 QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 424 Q++ +A QIA+GM Y+ ++VHRDL N LVGENL+ K+ DFG++R + +Y G Sbjct: 129 QMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGG 188 Query: 425 -AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 483 PI+W PE+ +Y +FT +SDVWS G++L E+ T G+ P+ + N EV++ + +G Sbjct: 189 HTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRV 248 Query: 484 MPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 + P CP+ +++LM CW++EP R + + L++ P Y Sbjct: 249 LQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQN-LAKASPVY 294 >5U6B-A nrPDB Length = 307 Score = 180 bits (457), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 108/289 (37%), Positives = 158/289 (54%), Gaps = 20/289 (6%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWN---GTTRVAIKTLKPGTMSP---EAFLQEAQVMK 318 + R + L LG+G FG V G N +VA+KT+K + E FL EA MK Sbjct: 20 VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK 79 Query: 319 KLRHEKLVQLYAVV---SEEPIY----IVTEYMSKGSLLDFLK----GETGKYLRLPQLV 367 + H +++L V SE + ++ +M G L FL G+ YL LV Sbjct: 80 EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLV 139 Query: 368 DMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG--A 425 A IASGM Y+ ++HRDL A N ++ EN+ VADFGL++ I + +Y RQG A Sbjct: 140 KFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYY-RQGRIA 198 Query: 426 KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP 485 K P+KW A E+ +T KSDVWSFG+ + E+ T+G+ PYPG+ N E+ D + +G R+ Sbjct: 199 KMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLK 258 Query: 486 CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGE 534 P +C + L+ LM +CW P++RP+F L+ LE+ + P +P E Sbjct: 259 QPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDE 307 >5X02-A nrPDB Length = 347 Score = 180 bits (457), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 108/290 (37%), Positives = 155/290 (53%), Gaps = 33/290 (11%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR------VAIKTLKPGTMSPE--AFLQEA 314 WE PRE+L LG G FG+V T G ++ VA+K LK S E A + E Sbjct: 43 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSEL 102 Query: 315 QVMKKL-RHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKY------------ 360 ++M +L HE +V L A PIY++ EY G LL++L+ + K+ Sbjct: 103 KMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKR 162 Query: 361 ---------LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLA 411 L L+ A Q+A GM ++E + VHRDL A N+LV V K+ DFGLA Sbjct: 163 LEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLA 222 Query: 412 R-LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM- 469 R ++ D+ Y R A+ P+KW APE+ G +TIKSDVWS+GILL E+ + G PYPG+ Sbjct: 223 RDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIP 282 Query: 470 VNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFL 519 V+ ++ G++M P E ++ +M CW + +RP+F L +FL Sbjct: 283 VDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 332 >1U59-A nrPDB Length = 287 Score = 180 bits (457), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 98/256 (38%), Positives = 153/256 (59%), Gaps = 9/256 (3%) Query: 265 IPRESLRL-EVKLGQGCFGEVWMGTWNGTTR---VAIKTLKPGT--MSPEAFLQEAQVMK 318 + R++L + +++LG G FG V G + + VAIK LK GT E ++EAQ+M Sbjct: 6 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMH 65 Query: 319 KLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378 +L + +V+L V E + +V E G L FL G+ + + + + ++ Q++ GM Sbjct: 66 QLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSMGMK 124 Query: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEA 436 Y+E N+VHRDL A N+L+ K++DFGL++ + +D+ YTAR K+P+KW APE Sbjct: 125 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 184 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 + +F+ +SDVWS+G+ + E + G+ PY M EV+ +E+G RM CPPECP L+ Sbjct: 185 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA 244 Query: 497 LMCQCWRKEPEERPTF 512 LM CW + E+RP F Sbjct: 245 LMSDCWIYKWEDRPDF 260 >4XUF-A nrPDB Length = 297 Score = 180 bits (456), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 108/290 (37%), Positives = 155/290 (53%), Gaps = 33/290 (11%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR------VAIKTLKPGTMSPE--AFLQEA 314 WE PRE+L LG G FG+V T G ++ VA+K LK S E A + E Sbjct: 4 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSEL 63 Query: 315 QVMKKL-RHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKY------------ 360 ++M +L HE +V L A PIY++ EY G LL++L+ + K+ Sbjct: 64 KMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKR 123 Query: 361 ---------LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLA 411 L L+ A Q+A GM ++E + VHRDL A N+LV V K+ DFGLA Sbjct: 124 LEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLA 183 Query: 412 R-LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM- 469 R ++ D+ Y R A+ P+KW APE+ G +TIKSDVWS+GILL E+ + G PYPG+ Sbjct: 184 RDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIP 243 Query: 470 VNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFL 519 V+ ++ G++M P E ++ +M CW + +RP+F L +FL Sbjct: 244 VDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 293 >6FEX-A nrPDB Length = 321 Score = 180 bits (456), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 108/304 (35%), Positives = 162/304 (53%), Gaps = 41/304 (13%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-----------------VAIKTLKPGTM- 305 + PR LR + KLG+G FGEV + + VA+K L+P Sbjct: 12 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 71 Query: 306 -SPEAFLQEAQVMKKLRHEKLVQLYAV-VSEEPIYIVTEYMSKGSLLDFL---------- 353 + FL+E ++M +L+ +++L V V ++P+ ++T+YM G L FL Sbjct: 72 NARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAA 131 Query: 354 KGETGK-YLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR 412 +G G + P L+ +AAQIASGM Y+ +N+VHRDL N LVGEN K+ADFG++R Sbjct: 132 EGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSR 191 Query: 413 LIEDNEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRV-PYPGMV 470 + +Y QG A PI+W A E L G+FT SDVW+FG+ L E+ R P+ + Sbjct: 192 NLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLT 251 Query: 471 NREVLDQVERGYR-------MPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFL-EDY 522 + +V++ +R + PP CP+ L++LM +CW +E E+RP F L FL ED Sbjct: 252 DEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDA 311 Query: 523 FTST 526 + Sbjct: 312 LNTV 315 >3TT0-A nrPDB Length = 382 Score = 179 bits (454), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 105/294 (35%), Positives = 156/294 (53%), Gaps = 27/294 (9%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTW--------NGTTRVAIKTLKPGTMSPEA--FLQ 312 WE+PR+ L L LG+G FG+V + N T+VA+K LK + + Sbjct: 64 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLIS 123 Query: 313 EAQVMKKL-RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGET------------- 357 E ++MK + +H+ ++ L +++ P+Y++ EY SKG+L ++L+ Sbjct: 124 EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHN 183 Query: 358 -GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED 416 + L LV A Q+A GM Y+ +HRDL A N+LV E+ V K+ADFGLAR I Sbjct: 184 PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHH 243 Query: 417 NEYTARQ-GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVL 475 +Y + + P+KW APEA +T +SDVWSFG+LL E+ T G PYPG+ E+ Sbjct: 244 IDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF 303 Query: 476 DQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 ++ G+RM P C L+ +M CW P +RPTF+ L L+ T Q Sbjct: 304 KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 357 >3GQL-A nrPDB Length = 326 Score = 179 bits (453), Expect = 3e-45, Method: Compositional matrix adjust. Identities = 105/294 (35%), Positives = 156/294 (53%), Gaps = 27/294 (9%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTW--------NGTTRVAIKTLKPGTMSPEA--FLQ 312 WE+PR+ L L LG+G FG+V + N T+VA+K LK + + Sbjct: 23 WELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLIS 82 Query: 313 EAQVMKKL-RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGET------------- 357 E ++MK + +H+ ++ L +++ P+Y++ EY SKG+L ++L+ Sbjct: 83 EMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHN 142 Query: 358 -GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED 416 + L LV A Q+A GM Y+ +HRDL A N+LV E+ V K+ADFGLAR I Sbjct: 143 PEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHH 202 Query: 417 NEYTARQ-GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVL 475 +Y + + P+KW APEA +T +SDVWSFG+LL E+ T G PYPG+ E+ Sbjct: 203 IDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELF 262 Query: 476 DQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 ++ G+RM P C L+ +M CW P +RPTF+ L L+ T Q Sbjct: 263 KLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 316 >4K33-A nrPDB Length = 325 Score = 177 bits (450), Expect = 8e-45, Method: Compositional matrix adjust. Identities = 106/295 (35%), Positives = 156/295 (52%), Gaps = 27/295 (9%) Query: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR--------VAIKTLKPGTMSPEA- 309 A WE+ R L L LG+G FG+V M G + VA+K LK + Sbjct: 27 ADPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLS 86 Query: 310 -FLQEAQVMKKL-RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKG----------E 356 + E ++MK + +H+ ++ L ++ P+Y++ EY +KG+L +FL+ + Sbjct: 87 DLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFD 146 Query: 357 TGK----YLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR 412 T K L LV A Q+A GM Y+ +HRDL A N+LV E+ V K+ADFGLAR Sbjct: 147 TSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLAR 206 Query: 413 LIED-NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVN 471 + + + Y + P+KW APEA +T +SDVWSFG+LL E+ T G PYPG+ Sbjct: 207 DVHNLDYYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPV 266 Query: 472 REVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 E+ ++ G+RM P C L+ +M +CW P +RPTF+ L L+ T T Sbjct: 267 EELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVT 321 >5KMM-A nrPDB Length = 329 Score = 177 bits (448), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 99/279 (35%), Positives = 162/279 (58%), Gaps = 22/279 (7%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGT------TRVAIKTLKPGTMSP-EAFLQEAQV 316 I R + L+ +LG+G FG+V++ + VA+K LK + S + F +EA++ Sbjct: 31 HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAEL 90 Query: 317 MKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLK--GETGKYLR----------- 362 + L+H+ +V+ + V +E P+ +V EYM G L FL+ G K L Sbjct: 91 LTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLG 150 Query: 363 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTAR 422 L QL+ +A+Q+A+GM Y+ +++VHRDL N LVG+ LV K+ DFG++R I +Y Sbjct: 151 LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRV 210 Query: 423 QG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481 G PI+W PE+ LY +FT +SDVWSFG++L E+ T G+ P+ + N E +D + +G Sbjct: 211 GGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQG 270 Query: 482 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 + P CP ++ +M CW++EP++R + + + A L+ Sbjct: 271 RELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQ 309 >5EG3-A nrPDB Length = 334 Score = 176 bits (446), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 105/291 (36%), Positives = 156/291 (53%), Gaps = 27/291 (9%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR--------VAIKTLKPGTMSPEA--FLQ 312 WE PR+ L L LG+G FG+V M G + VA+K LK + + Sbjct: 30 WEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVS 89 Query: 313 EAQVMKKL-RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGET--GKYL-----RL 363 E ++MK + +H+ ++ L +++ P+Y++ Y SKG+L ++L+ G L R+ Sbjct: 90 EMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDINRV 149 Query: 364 PQ-------LVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED 416 P+ LV Q+A GM Y+ +HRDL A N+LV EN V K+ADFGLAR I + Sbjct: 150 PEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINN 209 Query: 417 NEYTARQ-GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVL 475 ++ + P+KW APEA +T +SDVWSFG+L+ E+ T G PYPG+ E+ Sbjct: 210 IDFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELF 269 Query: 476 DQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 ++ G+RM P C L+ +M CW P +RPTF+ L L+ T T Sbjct: 270 KLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT 320 >3AOX-A nrPDB Length = 344 Score = 176 bits (445), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 106/279 (37%), Positives = 155/279 (55%), Gaps = 20/279 (7%) Query: 261 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT------TRVAIKTLKPGTMSPEA---FL 311 D E+PR+++ L LG G FGEV+ G +G +VA+KTL P S + FL Sbjct: 40 DLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTL-PEVCSEQDELDFL 98 Query: 312 QEAQVMKKLRHEKLVQLYAV-VSEEPIYIVTEYMSKGSLLDFLKGETGK-----YLRLPQ 365 EA ++ K H+ +V+ V + P +I+ E M+ G L FL+ + L + Sbjct: 99 MEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLD 158 Query: 366 LVDMAAQIASGMAYVERMNYVHRDLRAANILV---GENLVCKVADFGLARLIEDNEYTAR 422 L+ +A IA G Y+E +++HRD+ A N L+ G V K+ DFG+AR I Y + Sbjct: 159 LLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRK 218 Query: 423 QG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481 G A P+KW PEA + G FT K+D WSFG+LL E+ + G +PYP N+EVL+ V G Sbjct: 219 GGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSG 278 Query: 482 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 RM P CP ++ +M QCW+ +PE+RP F + +E Sbjct: 279 GRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIE 317 >3BBT-B nrPDB Length = 328 Score = 175 bits (443), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 108/255 (42%), Positives = 143/255 (56%), Gaps = 19/255 (7%) Query: 276 LGQGCFGEVWMGTW--NGTTR---VAIKTLKPGTMSPEA---FLQEAQVMKKLRHEKLVQ 327 LG G FG V+ G W G T VAIK L T P+A F+ EA +M + H LV+ Sbjct: 23 LGSGAFGTVYKGIWVPEGETVKIPVAIKILNETT-GPKANVEFMDEALIMASMDHPHLVR 81 Query: 328 LYAVVSEEPIYIVTEYMSKGSLLDFL---KGETGKYLRLPQLVDMAAQIASGMAYVERMN 384 L V I +VT+ M G LL+++ K G L L++ QIA GM Y+E Sbjct: 82 LLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQL----LLNWCVQIAKGMMYLEERR 137 Query: 385 YVHRDLRAANILVGENLVCKVADFGLARLIE--DNEYTARQGAKFPIKWTAPEAALYGRF 442 VHRDL A N+LV K+ DFGLARL+E + EY A G K PIKW A E Y +F Sbjct: 138 LVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNA-DGGKMPIKWMALECIHYRKF 196 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCW 502 T +SDVWS+G+ + EL T G PY G+ RE+ D +E+G R+P PP C ++ +M +CW Sbjct: 197 THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCW 256 Query: 503 RKEPEERPTFEYLQA 517 + + RP F+ L A Sbjct: 257 MIDADSRPKFKELAA 271 >3G0E-A nrPDB Length = 336 Score = 174 bits (442), Expect = 6e-44, Method: Compositional matrix adjust. Identities = 102/286 (35%), Positives = 149/286 (52%), Gaps = 28/286 (9%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR------VAIKTLKPGT--MSPEAFLQEA 314 WE PR L LG G FG+V T G + VA+K LKP EA + E Sbjct: 41 WEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSEL 100 Query: 315 QVMKKL-RHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYL---RLPQLV-- 367 +V+ L H +V L A P ++TEY G LL+FL+ + ++ P ++ Sbjct: 101 KVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKTSPAIMED 160 Query: 368 -----------DMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE- 415 + Q+A GMA++ N +HRDL A NIL+ + K+ DFGLAR I+ Sbjct: 161 DELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKN 220 Query: 416 DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREV 474 D+ Y + A+ P+KW APE+ +T +SDVWS+GI L EL + G PYPGM V+ + Sbjct: 221 DSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKF 280 Query: 475 LDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 ++ G+RM P P ++D+M CW +P +RPTF+ + +E Sbjct: 281 YKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIE 326 >3ZZW-A nrPDB Length = 289 Score = 174 bits (440), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 100/280 (35%), Positives = 154/280 (55%), Gaps = 24/280 (8%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNG------TTRVAIKTLKPGTMSP--EAFLQEAQ 315 EI ++R +LG+ FG+V+ G G T VAIKTLK P E F EA Sbjct: 5 EISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAM 64 Query: 316 VMKKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFL-----KGETGKY--------- 360 + +L+H +V L VV+ ++P+ ++ Y S G L +FL + G Sbjct: 65 LRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSA 124 Query: 361 LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT 420 L P V + AQIA+GM Y+ + VH+DL N+LV + L K++D GL R + +Y Sbjct: 125 LEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYY 184 Query: 421 ARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE 479 G + PI+W APEA +YG+F+I SD+WS+G++L E+ + G PY G N++V++ + Sbjct: 185 KLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIR 244 Query: 480 RGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFL 519 +PCP +CP ++ LM +CW + P RP F+ + + L Sbjct: 245 NRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRL 284 >3QUP-A nrPDB Length = 323 Score = 172 bits (436), Expect = 3e-43, Method: Compositional matrix adjust. Identities = 108/293 (36%), Positives = 158/293 (53%), Gaps = 28/293 (9%) Query: 265 IPRESLRLEVKLGQGCFG---EVWMGTWNGT-TRVAIKTLKPGTMSP---EAFLQEAQVM 317 IP + L LG+G FG E + +G+ +VA+K LK ++ E FL+EA M Sbjct: 20 IPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACM 79 Query: 318 KKLRHEKLVQLYAVVSEE------PI-YIVTEYMSKGSLLDFLK----GETGKYLRLPQL 366 K+ H + +L V PI ++ +M G L FL GE L L L Sbjct: 80 KEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTL 139 Query: 367 VDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG-- 424 V IA GM Y+ N++HRDL A N ++ E++ VADFGL+R I +Y RQG Sbjct: 140 VRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYY-RQGCA 198 Query: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484 +K P+KW A E+ +T+ SDVW+FG+ + E+ T+G+ PY G+ N E+ + + G R+ Sbjct: 199 SKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRL 258 Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF-------TSTEPQY 530 PPEC E ++DLM QCW +P++RP+F L+ LE+ TS +P Y Sbjct: 259 KQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGHLSVLSTSQDPLY 311 >6FER-A nrPDB Length = 309 Score = 172 bits (435), Expect = 4e-43, Method: Compositional matrix adjust. Identities = 100/293 (34%), Positives = 155/293 (52%), Gaps = 37/293 (12%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-----------------VAIKTLKP--GT 304 E PR+ L + KLG+G FGEV + G + VA+K L+ Sbjct: 5 EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANK 64 Query: 305 MSPEAFLQEAQVMKKLRHEKLVQLYAV-VSEEPIYIVTEYMSKGSLLDFLK--------G 355 + FL+E ++M +L+ ++ L AV ++++P+ ++TEYM G L FL Sbjct: 65 NARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSS 124 Query: 356 ETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE 415 + + L MA QIASGM Y+ +N+VHRDL N LVG+N K+ADFG++R + Sbjct: 125 SDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLY 184 Query: 416 DNEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE-LTTKGRVPYPGMVNRE 473 +Y QG A PI+W + E+ L G+FT SDVW+FG+ L E T PY + + + Sbjct: 185 SGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQ 244 Query: 474 VLDQVERGYR-------MPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFL 519 V++ +R +P P CP+S++ LM CWR++ + RP+F+ + L Sbjct: 245 VIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLL 297 >3PP0-A nrPDB Length = 338 Score = 171 bits (434), Expect = 5e-43, Method: Compositional matrix adjust. Identities = 105/250 (42%), Positives = 142/250 (56%), Gaps = 13/250 (5%) Query: 276 LGQGCFGEVWMGTW-----NGTTRVAIKTLKPGTMSPEA---FLQEAQVMKKLRHEKLVQ 327 LG G FG V+ G W N VAIK L+ T SP+A L EA VM + + + Sbjct: 25 LGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENT-SPKANKEILDEAYVMAGVGSPYVSR 83 Query: 328 LYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 L + + +VT+ M G LLD ++ G+ L L++ QIA GM+Y+E + VH Sbjct: 84 LLGICLTSTVQLVTQLMPYGCLLDHVRENRGR-LGSQDLLNWCMQIAKGMSYLEDVRLVH 142 Query: 388 RDLRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445 RDL A N+LV K+ DFGLARL I++ EY A G K PIKW A E+ L RFT + Sbjct: 143 RDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHA-DGGKVPIKWMALESILRRRFTHQ 201 Query: 446 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKE 505 SDVWS+G+ + EL T G PY G+ RE+ D +E+G R+P PP C ++ +M +CW + Sbjct: 202 SDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMID 261 Query: 506 PEERPTFEYL 515 E RP F L Sbjct: 262 SECRPRFREL 271 >5U6C-A nrPDB Length = 315 Score = 171 bits (432), Expect = 8e-43, Method: Compositional matrix adjust. Identities = 107/281 (38%), Positives = 158/281 (56%), Gaps = 22/281 (7%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTW---NGTT-RVAIKTLKPGTMSP---EAFLQEAQVM 317 I R L L LG+G FG V G +GT+ +VA+KT+K S E FL EA M Sbjct: 33 IDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACM 92 Query: 318 KKLRHEKLVQLYAVVSE-------EPIYIVTEYMSKGSLLDFL---KGETG-KYLRLPQL 366 K H +++L V E +P+ ++ +M G L +L + ETG K++ L L Sbjct: 93 KDFSHPNVMRLLGVCIEMSSQGIPKPM-VILPFMKYGDLHTYLLYSRLETGPKHIPLQTL 151 Query: 367 VDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG-- 424 + IA GM Y+ N++HRDL A N ++ +++ VADFGL++ I +Y RQG Sbjct: 152 LKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDY-YRQGRI 210 Query: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484 AK P+KW A E+ +T KSDVW+FG+ + E+ T+G PYPG+ N E+ D + G+R+ Sbjct: 211 AKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRL 270 Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTS 525 P +C + L+++M CWR +P +RPTF L+ LE S Sbjct: 271 KQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLES 311 >3PLS-A nrPDB Length = 298 Score = 170 bits (430), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 100/261 (38%), Positives = 146/261 (55%), Gaps = 12/261 (4%) Query: 276 LGQGCFGEVWMGTW----NGTTRVAIKTLKPGT--MSPEAFLQEAQVMKKLRHEKLVQLY 329 +G+G FG V+ G + + AIK+L T EAFL+E +M+ L H ++ L Sbjct: 29 IGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALI 88 Query: 330 AVV--SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 ++ E +++ YM G LL F++ + + L+ Q+A GM Y+ +VH Sbjct: 89 GIMLPPEGLPHVLLPYMCHGDLLQFIRSPQ-RNPTVKDLISFGLQVARGMEYLAEQKFVH 147 Query: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ---GAKFPIKWTAPEAALYGRFTI 444 RDL A N ++ E+ KVADFGLAR I D EY + Q A+ P+KWTA E+ RFT Sbjct: 148 RDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTYRFTT 207 Query: 445 KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRK 504 KSDVWSFG+LL EL T+G PY + ++ + +G R+P P CP+SL+ +M QCW Sbjct: 208 KSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEA 267 Query: 505 EPEERPTFEYLQAFLEDYFTS 525 +P RPTF L +E ++ Sbjct: 268 DPAVRPTFRVLVGEVEQIVSA 288 >4FL3-A nrPDB Length = 635 Score = 170 bits (430), Expect = 2e-42, Method: Compositional matrix adjust. Identities = 98/268 (36%), Positives = 152/268 (56%), Gaps = 11/268 (4%) Query: 265 IPRESLRLEVK-LGQGCFGEVWMGTWN---GTTRVAIKTLKPGTMSP---EAFLQEAQVM 317 + R+ L LE K LG G FG V G + VA+K LK P + L EA VM Sbjct: 365 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 424 Query: 318 KKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 ++L + +V++ + E +V E G L +L + ++++ ++++ Q++ GM Sbjct: 425 QQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYL--QQNRHVKDKNIIELVHQVSMGM 482 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPE 435 Y+E N+VHRDL A N+L+ K++DFGL++ + ++N Y A+ K+P+KW APE Sbjct: 483 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 Query: 436 AALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLH 495 Y +F+ KSDVWSFG+L+ E + G+ PY GM EV +E+G RM CP CP ++ Sbjct: 543 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 602 Query: 496 DLMCQCWRKEPEERPTFEYLQAFLEDYF 523 DLM CW + E RP F ++ L +Y+ Sbjct: 603 DLMNLCWTYDVENRPGFAAVELRLRNYY 630 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 42/107 (39%), Positives = 57/107 (53%), Gaps = 8/107 (7%) Query: 151 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 210 W+ GKI+R ESE+++L G FL+R + G+Y L + K V HY+I K Sbjct: 168 WFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCL--LHEGK---VLHYRIDKD 221 Query: 211 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQG 257 +G I +F++L QLV +YS ADGL LT C K TQG Sbjct: 222 KTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPC--QKIGTQG 266 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 53/196 (27%), Positives = 79/196 (40%), Gaps = 29/196 (14%) Query: 143 SDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV 202 +DS ++FG ITR E+E L+ G +L+R+S G + LSV A G Sbjct: 7 ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSV-----AHGRKA 61 Query: 203 KHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDA 262 HY I + +G + I S L Y+S+ +DGL VC KP + Sbjct: 62 HHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGL------VCLLKKPFNRPQGVQP 115 Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV---AIKTLKPGTMSPEAFLQEAQVMKK 319 P E L+ + E TWN + AI + KP Q +++ Sbjct: 116 KTGPFEDLK------ENLIREYVKQTWNLQGQALEQAIISQKP---------QLEKLIAT 160 Query: 320 LRHEKLVQLYAVVSEE 335 HEK+ + +S E Sbjct: 161 TAHEKMPWFHGKISRE 176 >5HLW-A nrPDB Length = 299 Score = 168 bits (426), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 97/261 (37%), Positives = 142/261 (54%), Gaps = 12/261 (4%) Query: 276 LGQGCFGEVWMGTW----NGTTRVAIKTLKPGTMSPEA--FLQEAQVMKKLRHEKLVQLY 329 +G+G FG V+ GT A+K+L T E FL E +MK H ++ L Sbjct: 28 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 87 Query: 330 AVV--SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 + SE +V YM G L +F++ ET + L+ Q+A GM Y+ +VH Sbjct: 88 GICLRSEGSPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKYLASKKFVH 146 Query: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTA---RQGAKFPIKWTAPEAALYGRFTI 444 RDL A N ++ E KVADFGLAR + D EY + + GAK P+KW A E+ +FT Sbjct: 147 RDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQTQKFTT 206 Query: 445 KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRK 504 KSDVWSFG+LL EL T+G PYP + ++ + +G R+ P CP+ L+++M +CW Sbjct: 207 KSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHP 266 Query: 505 EPEERPTFEYLQAFLEDYFTS 525 + E RP+F L + + F++ Sbjct: 267 KAEMRPSFSELVSRISAIFST 287 >1LUF-A nrPDB Length = 343 Score = 167 bits (424), Expect = 7e-42, Method: Compositional matrix adjust. Identities = 100/290 (34%), Positives = 152/290 (52%), Gaps = 34/290 (11%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGT------TRVAIKTLK---PGTMSPEAFLQEA 314 E PR ++ +G+G FG V+ G T VA+K LK M + F +EA Sbjct: 43 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQAD-FQREA 101 Query: 315 QVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKY------------- 360 +M + + +V+L V + +P+ ++ EYM+ G L +FL+ + Sbjct: 102 ALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRA 161 Query: 361 ---------LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLA 411 L + + +A Q+A+GMAY+ +VHRDL N LVGEN+V K+ADFGL+ Sbjct: 162 RVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLS 221 Query: 412 RLIEDNEYTARQGAK-FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMV 470 R I +Y G PI+W PE+ Y R+T +SDVW++G++L E+ + G PY GM Sbjct: 222 RNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMA 281 Query: 471 NREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 + EV+ V G + CP CP L++LM CW K P +RP+F + L+ Sbjct: 282 HEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRILQ 331 >5C26-A nrPDB Length = 299 Score = 167 bits (424), Expect = 9e-42, Method: Compositional matrix adjust. Identities = 98/268 (36%), Positives = 152/268 (56%), Gaps = 11/268 (4%) Query: 265 IPRESLRLEVK-LGQGCFGEVWMGTWN---GTTRVAIKTLKPGTMSP---EAFLQEAQVM 317 + R+ L LE K LG G FG V G + VA+K LK P + L EA VM Sbjct: 23 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 82 Query: 318 KKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 ++L + +V++ + E +V E G L +L + ++++ ++++ Q++ GM Sbjct: 83 QQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYL--QQNRHVKDKNIIELVHQVSMGM 140 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPE 435 Y+E N+VHRDL A N+L+ K++DFGL++ + ++N Y A+ K+P+KW APE Sbjct: 141 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 200 Query: 436 AALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLH 495 Y +F+ KSDVWSFG+L+ E + G+ PY GM EV +E+G RM CP CP ++ Sbjct: 201 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 260 Query: 496 DLMCQCWRKEPEERPTFEYLQAFLEDYF 523 DLM CW + E RP F ++ L +Y+ Sbjct: 261 DLMNLCWTYDVENRPGFAAVELRLRNYY 288 >1FVR-A nrPDB Length = 327 Score = 166 bits (419), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 95/265 (35%), Positives = 141/265 (53%), Gaps = 23/265 (8%) Query: 269 SLRLEVKLGQGCFGEVWMGTWNGT---TRVAIKTLKPGTMSPEA--FLQEAQVMKKL-RH 322 ++ + +G+G FG+V AIK +K + F E +V+ KL H Sbjct: 26 DIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHH 85 Query: 323 EKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLK--------------GETGKYLRLPQLV 367 ++ L +Y+ EY G+LLDFL+ T L QL+ Sbjct: 86 PNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLL 145 Query: 368 DMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKF 427 AA +A GM Y+ + ++HRDL A NILVGEN V K+ADFGL+R E Y + + Sbjct: 146 HFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQE--VYVKKTMGRL 203 Query: 428 PIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP 487 P++W A E+ Y +T SDVWS+G+LL E+ + G PY GM E+ +++ +GYR+ P Sbjct: 204 PVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKP 263 Query: 488 PECPESLHDLMCQCWRKEPEERPTF 512 C + ++DLM QCWR++P ERP+F Sbjct: 264 LNCDDEVYDLMRQCWREKPYERPSF 288 >3C1X-A nrPDB Length = 373 Score = 166 bits (419), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 96/261 (36%), Positives = 145/261 (55%), Gaps = 12/261 (4%) Query: 276 LGQGCFGEVWMGTW--NGTTRV--AIKTLKPGTMSPEA--FLQEAQVMKKLRHEKLVQLY 329 +G+G FG V+ GT N ++ A+K+L T E FL E +MK H ++ L Sbjct: 97 IGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLL 156 Query: 330 AVV--SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 + SE +V YM G L +F++ ET + L+ Q+A GM ++ +VH Sbjct: 157 GICLRSEGSPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKFLASKKFVH 215 Query: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTA---RQGAKFPIKWTAPEAALYGRFTI 444 RDL A N ++ E KVADFGLAR + D E+ + + GAK P+KW A E+ +FT Sbjct: 216 RDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQTQKFTT 275 Query: 445 KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRK 504 KSDVWSFG+LL EL T+G PYP + ++ + +G R+ P CP+ L+++M +CW Sbjct: 276 KSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHP 335 Query: 505 EPEERPTFEYLQAFLEDYFTS 525 + E RP+F L + + F++ Sbjct: 336 KAEMRPSFSELVSRISAIFST 356 >3CJF-A nrPDB Length = 309 Score = 162 bits (411), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 97/280 (34%), Positives = 147/280 (52%), Gaps = 23/280 (8%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR------VAIKTLKPGTMSPE--AFLQEA 314 WE PR+ L L LG+G FG+V G + VA+K LK G E A + E Sbjct: 22 WEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSEL 81 Query: 315 QVMKKL-RHEKLVQLYAVVSEE--PIYIVTEYMSKGSLLDFLKGETGKY----------L 361 +++ + H +V L ++ P+ ++ E+ G+L +L+ + ++ L Sbjct: 82 KILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDLYKDFL 141 Query: 362 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI-EDNEYT 420 L L+ + Q+A GM ++ +HRDL A NIL+ E V K+ DFGLAR I +D +Y Sbjct: 142 TLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYV 201 Query: 421 ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQVE 479 + A+ P+KW APE +TI+SDVWSFG+LL E+ + G PYPG+ ++ E +++ Sbjct: 202 RKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLK 261 Query: 480 RGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFL 519 G RM P ++ M CW EP +RPTF L L Sbjct: 262 EGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHL 301 >3LZB-A nrPDB Length = 327 Score = 157 bits (396), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 99/264 (37%), Positives = 145/264 (54%), Gaps = 15/264 (5%) Query: 276 LGQGCFGEVWMGTW-----NGTTRVAIKTLKPGTMSPEA---FLQEAQVMKKLRHEKLVQ 327 LG G FG V+ G W VAIK L+ T SP+A L EA VM + + + + Sbjct: 23 LGSGAFGTVYKGLWIPEGEKVKIPVAIKELREAT-SPKANKEILDEAYVMASVDNPHVCR 81 Query: 328 LYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 L + + ++T+ M G LLD+++ E + L++ QIA GM Y+E VH Sbjct: 82 LLGICLTSTVQLITQLMPFGCLLDYVR-EHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVH 140 Query: 388 RDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445 RDL A N+LV K+ DFGLA+L+ E+ EY A +G K PIKW A E+ L+ +T + Sbjct: 141 RDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHA-EGGKVPIKWMALESILHRIYTHQ 199 Query: 446 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKE 505 SDVWS+G+ + EL T G PY G+ E+ +E+G R+P PP C ++ +M +CW + Sbjct: 200 SDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMID 259 Query: 506 PEERPTFEYLQAFLEDYFTSTEPQ 529 + RP F L +E + +PQ Sbjct: 260 ADSRPKFREL--IIEFSKMARDPQ 281 >5GNK-A nrPDB Length = 297 Score = 156 bits (395), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 98/264 (37%), Positives = 144/264 (54%), Gaps = 15/264 (5%) Query: 276 LGQGCFGEVWMGTW-----NGTTRVAIKTLKPGTMSPEA---FLQEAQVMKKLRHEKLVQ 327 LG G FG V+ G W VAIK L+ T SP+A L EA VM + + + + Sbjct: 27 LGSGAFGTVYKGLWIPEGEKVKIPVAIKELREAT-SPKANKEILDEAYVMASVDNPHVCR 85 Query: 328 LYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 L + + ++ + M G LLD+++ E + L++ QIA GM Y+E VH Sbjct: 86 LLGICLTSTVQLIMQLMPFGCLLDYVR-EHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVH 144 Query: 388 RDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445 RDL A N+LV K+ DFGLA+L+ E+ EY A +G K PIKW A E+ L+ +T + Sbjct: 145 RDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHA-EGGKVPIKWMALESILHRIYTHQ 203 Query: 446 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKE 505 SDVWS+G+ + EL T G PY G+ E+ +E+G R+P PP C ++ +M +CW + Sbjct: 204 SDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMID 263 Query: 506 PEERPTFEYLQAFLEDYFTSTEPQ 529 + RP F L +E + +PQ Sbjct: 264 ADSRPKFREL--IIEFSKMARDPQ 285 >3OMV-A nrPDB Length = 307 Score = 155 bits (392), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 96/283 (33%), Positives = 154/283 (54%), Gaps = 20/283 (7%) Query: 252 KPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPE--- 308 +P+ Q + WEI + L ++G G FG V+ G W+G VA+K LK +PE Sbjct: 20 RPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGD--VAVKILKVVDPTPEQFQ 77 Query: 309 AFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD 368 AF E V++K RH ++ ++++ + IVT++ SL L + K+ ++ QL+D Sbjct: 78 AFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKF-QMFQLID 136 Query: 369 MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFP 428 +A Q A GM Y+ N +HRD+++ NI + E L K+ DFGLA + + ++ Q + P Sbjct: 137 IARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV--KSRWSGSQQVEQP 194 Query: 429 ---IKWTAPEAALY---GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR-EVLDQVERG 481 + W APE F+ +SDV+S+GI+L EL T G +PY + NR +++ V RG Sbjct: 195 TGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRG 253 Query: 482 YRMP----CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 Y P CP+++ L+ C +K EERP F + + +E Sbjct: 254 YASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIE 296 >6DBN-A nrPDB Length = 316 Score = 155 bits (392), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 92/266 (34%), Positives = 141/266 (53%), Gaps = 27/266 (10%) Query: 276 LGQGCFGEVWMGTW-----NGTTRVAIKTLKP--GTMSPEAFLQEAQVMKKLRHEKLVQL 328 LG+G FG+V + + N +VA+K+LKP G +E ++++ L HE +V+ Sbjct: 43 LGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKY 102 Query: 329 YAVVSEEP---IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 + +E+ I ++ E++ GSL ++L K + L Q + A QI GM Y+ Y Sbjct: 103 KGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNK-INLKQQLKYAVQICKGMDYLGSRQY 161 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNE--YTARQGAKFPIKWTAPEAALYGRFT 443 VHRDL A N+LV K+ DFGL + IE ++ YT + P+ W APE + +F Sbjct: 162 VHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFY 221 Query: 444 IKSDVWSFGILLTELTT-------------KGRVPYPG-MVNREVLDQVERGYRMPCPPE 489 I SDVWSFG+ L EL T K P G M +++ ++ G R+PCPP Sbjct: 222 IASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPN 281 Query: 490 CPESLHDLMCQCWRKEPEERPTFEYL 515 CP+ ++ LM +CW +P R +F+ L Sbjct: 282 CPDEVYQLMRKCWEFQPSNRTSFQNL 307 >4LRM-A nrPDB Length = 334 Score = 153 bits (387), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 96/253 (37%), Positives = 139/253 (54%), Gaps = 16/253 (6%) Query: 276 LGQGCFGEVWMGTW-----NGTTRVAIKTLKPGTMSPEA---FLQEAQVMKKLRHE---K 324 LG G FG V+ G W VAIK L+ T SP+A L EA VM + + Sbjct: 27 LGSGAFGTVYKGLWIPEGEKVKIPVAIKELREAT-SPKANKEILDEAYVMASVDNPGNPH 85 Query: 325 LVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN 384 + +L + + ++T+ M G LLD+++ E + L++ QIA GM Y+E Sbjct: 86 VCRLLGICLTSTVQLITQLMPFGCLLDYVR-EHKDNIGSQYLLNWCVQIAKGMNYLEDRR 144 Query: 385 YVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGRF 442 VHRDL A N+LV K+ DFGLA+L+ E+ EY A +G K PIKW A E+ L+ + Sbjct: 145 LVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHA-EGGKVPIKWMALESILHRIY 203 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCW 502 T +SDVWS+G+ + EL T G PY G+ E+ +E+G R+P PP C ++ +M +CW Sbjct: 204 THQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCW 263 Query: 503 RKEPEERPTFEYL 515 + + RP F L Sbjct: 264 MIDADSRPKFREL 276 >5HIE-A nrPDB Length = 302 Score = 152 bits (383), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 93/274 (33%), Positives = 150/274 (54%), Gaps = 21/274 (7%) Query: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 318 + D WEIP + + ++G G FG V+ G W+G VA+K L P + +AF E V++ Sbjct: 27 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD--VAVKMLTPQQL--QAFKNEVGVLR 82 Query: 319 KLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378 K RH ++ ++ + IVT++ SL L K+ + +L+D+A Q A GM Sbjct: 83 KTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKF-EMIKLIDIARQTAQGMD 141 Query: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLA----RLIEDNEYTARQGAKFPIKWTAP 434 Y+ + +HRDL++ NI + E+L K+ DFGLA R +++ G+ I W AP Sbjct: 142 YLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGS---ILWMAP 198 Query: 435 EAALY---GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR-EVLDQVERGYRMP----C 486 E ++ +SDV++FGI+L EL T G++PY + NR +++ V RGY P Sbjct: 199 EVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKV 257 Query: 487 PPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 CP+++ LM +C +K+ +ERP F + A +E Sbjct: 258 RSNCPKAMKRLMAECLKKKRDERPLFPQILASIE 291 >5HI2-A nrPDB Length = 283 Score = 151 bits (381), Expect = 7e-37, Method: Compositional matrix adjust. Identities = 91/275 (33%), Positives = 150/275 (54%), Gaps = 21/275 (7%) Query: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 318 + D WEIP + + ++G G FG V+ G W+G VA+K L P + +AF E V++ Sbjct: 11 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD--VAVKMLTPQQL--QAFKNEVGVLR 66 Query: 319 KLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378 K RH ++ ++ + IVT++ SL L K+ + +L+D+A Q A GM Sbjct: 67 KTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKF-EMKKLIDIARQTARGMD 125 Query: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLA----RLIEDNEYTARQGAKFPIKWTAP 434 Y+ + +HRDL++ NI + E+ K+ DFGLA R +++ G+ I W AP Sbjct: 126 YLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGS---ILWMAP 182 Query: 435 EAALY---GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNRE-VLDQVERGYRMP----C 486 E ++ +SDV++FGI+L EL T G++PY + NR+ +++ V RG P Sbjct: 183 EVIRMQDSNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIEMVGRGSLSPDLSKV 241 Query: 487 PPECPESLHDLMCQCWRKEPEERPTFEYLQAFLED 521 CP+ + LM +C +K+ +ERP+F + A +E+ Sbjct: 242 RSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEE 276 >5WNO-A nrPDB Length = 330 Score = 149 bits (376), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 91/261 (34%), Positives = 140/261 (53%), Gaps = 11/261 (4%) Query: 265 IPRESL--RLEVKLGQGCFGEVWMGTW------NGTTRVAIKTLKPGTMSPEAFLQEAQV 316 IP L +L+ KLG G FG V+ G + N VAIK + + L+EA Sbjct: 17 IPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATN 76 Query: 317 MKKLRHEKLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIAS 375 M +LRH+ L+++ + ++ + IVT Y G+L +FLK + L + V QIAS Sbjct: 77 MFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHK-ENLGAREQVLYCYQIAS 135 Query: 376 GMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAP 434 GM Y+E+ VHRDL N+LV + ++ DFGL+++++ D + + K IKW A Sbjct: 136 GMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAI 195 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESL 494 E +T SDVW+FG+ E+ T G+ PY GM + + ++ G R+ PP C + L Sbjct: 196 EIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDL 255 Query: 495 HDLMCQCWRKEPEERPTFEYL 515 + + +CW +P+ RP FE L Sbjct: 256 YQELLRCWMADPKSRPGFEIL 276 >3LMG-A nrPDB Length = 344 Score = 146 bits (369), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 92/249 (36%), Positives = 134/249 (53%), Gaps = 11/249 (4%) Query: 276 LGQGCFGEVWMGTW-----NGTTRVAIKTL--KPGTMSPEAFLQEAQVMKKLRHEKLVQL 328 LG G FG V G W + V IK + K G S +A + L H +V+L Sbjct: 39 LGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRL 98 Query: 329 YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLV-DMAAQIASGMAYVERMNYVH 387 + + +VT+Y+ GSLLD ++ G PQL+ + QIA GM Y+E VH Sbjct: 99 LGLCPGSSLQLVTQYLPLGSLLDHVRQHRGALG--PQLLLNWGVQIAKGMYYLEEHGMVH 156 Query: 388 RDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRFTIKS 446 R+L A N+L+ +VADFG+A L+ D++ AK PIKW A E+ +G++T +S Sbjct: 157 RNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQS 216 Query: 447 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEP 506 DVWS+G+ + EL T G PY G+ EV D +E+G R+ P C ++ +M +CW + Sbjct: 217 DVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDE 276 Query: 507 EERPTFEYL 515 RPTF+ L Sbjct: 277 NIRPTFKEL 285 >6DBM-A nrPDB Length = 318 Score = 143 bits (360), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 90/271 (33%), Positives = 135/271 (49%), Gaps = 29/271 (10%) Query: 276 LGQGCFGEVWMGTWNGTT-----RVAIKTLKP--GTMSPEAFLQEAQVMKKLRHEKLVQL 328 LG+G FG+V + ++ T VA+K LK G + QE +++ L HE +++ Sbjct: 39 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWKQEIDILRTLYHEHIIKY 98 Query: 329 YAVVSEE---PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 + + +V EY+ GSL D+L + + L QL+ A QI GMAY+ +Y Sbjct: 99 KGCCEDAGAASLQLVMEYVPLGSLRDYLPRHS---IGLAQLLLFAQQICEGMAYLHSQHY 155 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNE--YTARQGAKFPIKWTAPEAALYGRFT 443 +HRDL A N+L+ + + K+ DFGLA+ + + Y R+ P+ W APE +F Sbjct: 156 IHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFY 215 Query: 444 IKSDVWSFGILLTELTTKGR--------------VPYPGMVNREVLDQVERGYRMPCPPE 489 SDVWSFG+ L EL T + M + + +ERG R+P P + Sbjct: 216 YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDK 275 Query: 490 CPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 CP ++ LM CW E RPTFE L L+ Sbjct: 276 CPAEVYHLMKNCWETEASFRPTFENLIPILK 306 >4OLI-A nrPDB Length = 645 Score = 142 bits (358), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 90/271 (33%), Positives = 136/271 (50%), Gaps = 29/271 (10%) Query: 276 LGQGCFGEVWMGTWNGTT-----RVAIKTLKP--GTMSPEAFLQEAQVMKKLRHEKLVQL 328 LG+G FG+V + ++ T VA+K LK G + QE +++ L HE +++ Sbjct: 361 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKY 420 Query: 329 YAVVS---EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 E+ + +V EY+ GSL D+L + + L QL+ A QI GMAY+ +Y Sbjct: 421 KGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS---IGLAQLLLFAQQICEGMAYLHSQHY 477 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNE--YTARQGAKFPIKWTAPEAALYGRFT 443 +HR+L A N+L+ + + K+ DFGLA+ + + Y R+ P+ W APE +F Sbjct: 478 IHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFY 537 Query: 444 IKSDVWSFGILLTELTTKGR--------------VPYPGMVNREVLDQVERGYRMPCPPE 489 SDVWSFG+ L EL T + M + + +ERG R+P P + Sbjct: 538 YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDK 597 Query: 490 CPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 CP ++ LM CW E RPTFE L L+ Sbjct: 598 CPCEVYHLMKNCWETEASFRPTFENLIPILK 628 Score = 82.8 bits (203), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 73/232 (31%), Positives = 108/232 (46%), Gaps = 23/232 (9%) Query: 294 RVAIKTLKPGTMSPE-AFLQEAQVMKKLRHEKLVQLYAVVSEEPIYI-VTEYMSKGSLLD 351 RV +K L P AF + A +M ++ H L ++ V P I VTEY+ G L Sbjct: 96 RVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDV 155 Query: 352 FLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILV-------GENLVCK 404 +L+ E G ++V +A Q+AS ++Y+E N VH ++ NIL+ G + K Sbjct: 156 WLRRERGHVPMAWKMV-VAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIK 214 Query: 405 VAD--FGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS--DVWSFGILLTELTT 460 ++D GL L +R+ I W APE G ++ + D W FG L E+ Sbjct: 215 LSDPGVGLGAL-------SREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICF 267 Query: 461 KGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTF 512 G P E +R +R+P P CP+ L L QC EP +RP+F Sbjct: 268 DGEAPLQSRSPSEKEHFYQRQHRLP-EPSCPQ-LATLTSQCLTYEPTQRPSF 317 >4HVI-A nrPDB Length = 314 Score = 139 bits (350), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 99/272 (36%), Positives = 142/272 (52%), Gaps = 28/272 (10%) Query: 270 LRLEVKLGQGCFGEVWMGTW-----NGTTRVAIKTLK-PGTMSPEAFLQEAQVMKKLRHE 323 L+ +LG+G FG V + + N VA+K L+ G F +E Q++K L H Sbjct: 12 LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKAL-HS 70 Query: 324 KLVQLYAVVSEEP----IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 + Y VS P + +V EY+ G L DFL+ + L +L+ ++QI GM Y Sbjct: 71 DFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRAR-LDASRLLLYSSQICKGMEY 129 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAA 437 + VHRDL A NILV K+ADFGLA+L+ + + Y R+ + PI W APE+ Sbjct: 130 LGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESL 189 Query: 438 LYGRFTIKSDVWSFGILLTELTT---KGRVPYPGMVN-----REV------LDQVERGYR 483 F+ +SDVWSFG++L EL T K P + R+V L+ +E G R Sbjct: 190 SDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEGQR 249 Query: 484 MPCPPECPESLHDLMCQCWRKEPEERPTFEYL 515 +P PP CP +H+LM CW P++RP+F L Sbjct: 250 LPAPPACPAEVHELMKLCWAPSPQDRPSFSAL 281 >4E20-A nrPDB Length = 290 Score = 139 bits (350), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 91/272 (33%), Positives = 138/272 (50%), Gaps = 31/272 (11%) Query: 276 LGQGCFGEVWMGTWNGTT-----RVAIKTLKPGTMSPE---AFLQEAQVMKKLRHEKLVQ 327 LG+G FG+V + ++ T VA+K LK G P+ + +E ++++ L HE +V+ Sbjct: 16 LGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGC-GPQLRSGWQREIEILRTLYHEHIVK 74 Query: 328 LYAVVS---EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN 384 E+ + +V EY+ GSL D+L + L QL+ A QI GMAY+ + Sbjct: 75 YKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHC---VGLAQLLLFAQQICEGMAYLHAQH 131 Query: 385 YVHRDLRAANILVGENLVCKVADFGLARLIEDNE--YTARQGAKFPIKWTAPEAALYGRF 442 Y+HR L A N+L+ + + K+ DFGLA+ + + Y R+ P+ W APE +F Sbjct: 132 YIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKF 191 Query: 443 TIKSDVWSFGILLTELTT---KGRVPYPG-----------MVNREVLDQVERGYRMPCPP 488 SDVWSFG+ L EL T + P+ M + + +ERG R+P P Sbjct: 192 YYASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRLTELLERGERLPRPD 251 Query: 489 ECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 CP ++ LM CW E RPTF+ L L+ Sbjct: 252 RCPCEIYHLMKNCWETEASFRPTFQNLVPILQ 283 >4RT7-A nrPDB Length = 415 Score = 138 bits (347), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 68/161 (42%), Positives = 98/161 (60%), Gaps = 2/161 (1%) Query: 361 LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR-LIEDNEY 419 L L+ A Q+A GM ++E + VHRDL A N+LV V K+ DFGLAR ++ D+ Y Sbjct: 240 LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNY 299 Query: 420 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQV 478 R A+ P+KW APE+ G +TIKSDVWS+GILL E+ + G PYPG+ V+ + Sbjct: 300 VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLI 359 Query: 479 ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFL 519 + G++M P E ++ +M CW + +RP+F L +FL Sbjct: 360 QNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 400 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 41/110 (37%), Positives = 58/110 (52%), Gaps = 10/110 (9%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR------VAIKTLKPGTMSP--EAFLQEA 314 WE PRE+L LG G FG+V T G ++ VA+K LK S EA + E Sbjct: 60 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSEL 119 Query: 315 QVMKKL-RHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLR 362 ++M +L HE +V L A PIY++ EY G LL++L+ + K+ R Sbjct: 120 KMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHR 169 >3PPZ-A nrPDB Length = 309 Score = 136 bits (343), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 95/276 (34%), Positives = 141/276 (51%), Gaps = 11/276 (3%) Query: 261 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPE---AFLQEAQVM 317 D +IP L ++ K+G G FG V W+G+ VA+K L E FL+E +M Sbjct: 30 DDMDIPWCDLNIKEKIGAGSFGTVHRAEWHGSD-VAVKILMEQDFHAERVNEFLREVAIM 88 Query: 318 KKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFL-KGETGKYLRLPQLVDMAAQIAS 375 K+LRH +V V++ P + IVTEY+S+GSL L K + L + + MA +A Sbjct: 89 KRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAK 148 Query: 376 GMAYVERMN--YVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 433 GM Y+ N VHRDL++ N+LV + KV DFGL+RL +++ A P +W A Sbjct: 149 GMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTP-EWMA 207 Query: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPPECPE 492 PE KSDV+SFG++L EL T + P+ + +V+ V + R+ P Sbjct: 208 PEVLRDEPSNEKSDVYSFGVILWELATLQQ-PWGNLNPAQVVAAVGFKCKRLEIPRNLNP 266 Query: 493 SLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEP 528 + ++ CW EP +RP+F + L S P Sbjct: 267 QVAAIIEGCWTNEPWKRPSFATIMDLLRPLIKSAVP 302 >5X5O-A nrPDB Length = 310 Score = 135 bits (340), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 82/269 (30%), Positives = 137/269 (50%), Gaps = 17/269 (6%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRH 322 +I + L+ G G FG V+ W + VA+K L +EA+++ L H Sbjct: 11 QIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-------IEKEAEILSVLSH 63 Query: 323 EKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 ++Q Y V+ E P Y IVTEY S GSL D++ + + + ++ A +A GM Y+ Sbjct: 64 RNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLH 123 Query: 382 R---MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438 + +HRDL++ N+++ + V K+ DFG +R + + G FP W APE Sbjct: 124 MEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQ 180 Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREV-LDQVERGYRMPCPPECPESLHDL 497 + D +S+G++L E+ T+ VP+ G+ +V VE+ R+ P CP S +L Sbjct: 181 SLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAEL 239 Query: 498 MCQCWRKEPEERPTFEYLQAFLEDYFTST 526 + QCW + ++RP+F+ + + LE T Sbjct: 240 LHQCWEADAKKRPSFKQIISILESMSNDT 268 >4UYA-A nrPDB Length = 340 Score = 135 bits (339), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 99/279 (35%), Positives = 144/279 (51%), Gaps = 36/279 (12%) Query: 271 RLEVK--LGQGCFGEVWMGTWNGTTRVAIKTLK-----PGTMSPEAFLQEAQVMKKLRHE 323 RLE+K +G G FG+V+ TW G VA+K + + E+ +EA++ LRH Sbjct: 27 RLELKELIGAGGFGQVYRATWQGQ-EVAVKAARQDPEQDAAAAAESVRREARLFAMLRHP 85 Query: 324 KLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLP--QLVDMAAQIASGMAYV 380 +++L V ++P + +V E+ G+L L G R+P LV+ A QIA GM Y+ Sbjct: 86 NIIELRGVCLQQPHLCLVLEFARGGALNRALAGR-----RIPPHVLVNWAVQIARGMLYL 140 Query: 381 ERMNYV---HRDLRAANILVGENL----VC----KVADFGLARLIEDNEYTARQGAKFPI 429 +V HRDL+++NIL+ E + +C K+ DFGLAR A GA Sbjct: 141 HEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAGA---Y 197 Query: 430 KWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPP 488 W APE F+ SD+WS+G+LL EL T G VPY G+ V V +P P Sbjct: 198 AWMAPEVIKSSLFSKGSDIWSYGVLLWELLT-GEVPYRGIDGLAVAYGVAVNKLTLPIPS 256 Query: 489 ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE 527 CPE LM +CW+++P RP+F A + + T+ E Sbjct: 257 TCPEPFAKLMKECWQQDPHIRPSF----ALILEQLTAIE 291 >2W1I-A nrPDB Length = 326 Score = 134 bits (338), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 86/283 (30%), Positives = 144/283 (50%), Gaps = 29/283 (10%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMGTW-----NGTTRVAIKTLKPGTMSP-EAFLQE 313 +D + L+ +LG+G FG V M + N VA+K L+ T F +E Sbjct: 33 RDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFERE 92 Query: 314 AQVMKKLRHEKLVQLYAV---VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMA 370 +++K L+H+ +V+ V + ++ EY+ GSL D+L+ + + +L+ Sbjct: 93 IEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHI-KLLQYT 151 Query: 371 AQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI-EDNEY-TARQGAKFP 428 +QI GM Y+ Y+HRDL NILV K+ DFGL +++ +D EY ++ + P Sbjct: 152 SQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESP 211 Query: 429 IKWTAPEAALYGRFTIKSDVWSFGILLTELTT---KGRVPYPG-------------MVNR 472 I W APE+ +F++ SDVWSFG++L EL T K + P P M+ Sbjct: 212 IFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSP-PAEFMRMIGNDKQGQMIVF 270 Query: 473 EVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYL 515 +++ ++ R+P P CP+ ++ +M +CW +RP+F L Sbjct: 271 HLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 313 >5VO2-A nrPDB Length = 300 Score = 133 bits (335), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 79/266 (29%), Positives = 140/266 (52%), Gaps = 18/266 (6%) Query: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQV-- 316 ++D WE+P E + +G G G V++G ++G VA+K ++ L+E + Sbjct: 3 SEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGE-EVAVKKVRD--------LKETDIKH 53 Query: 317 MKKLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIAS 375 ++KL+H ++ V ++ P Y I+ E+ ++G L + L+ G+ + LVD + IA Sbjct: 54 LRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRA--GRPVTPSLLVDWSMGIAG 111 Query: 376 GMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPE 435 GM Y+ +HRDL++ N+L+ + V K++DFG ++ + D + + + W APE Sbjct: 112 GMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDK--STKMSFAGTVAWMAPE 169 Query: 436 AALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESL 494 + K D+WSFG++L EL T G +PY + + ++ V +P P CP+ Sbjct: 170 VIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGF 228 Query: 495 HDLMCQCWRKEPEERPTFEYLQAFLE 520 L+ QCW +P RP+F + L+ Sbjct: 229 KILLRQCWNSKPRNRPSFRQILLHLD 254 >3IO7-A nrPDB Length = 313 Score = 132 bits (333), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 85/273 (31%), Positives = 141/273 (51%), Gaps = 29/273 (10%) Query: 270 LRLEVKLGQGCFGEVWMGTW-----NGTTRVAIKTLKPGTMSP-EAFLQEAQVMKKLRHE 323 L+ +LG+G FG V M + N VA+K L+ T F +E +++K L+H+ Sbjct: 30 LKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHD 89 Query: 324 KLVQLYAV---VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 +V+ V + ++ EY+ GSL D+L+ + + +L+ +QI GM Y+ Sbjct: 90 NIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHI-KLLQYTSQICKGMEYL 148 Query: 381 ERMNYVHRDLRAANILVGENLVCKVADFGLARLI-EDNEY-TARQGAKFPIKWTAPEAAL 438 Y+HRDL NILV K+ DFGL +++ +D EY ++ + PI W APE+ Sbjct: 149 GTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLT 208 Query: 439 YGRFTIKSDVWSFGILLTELTT---KGRVPYPG-------------MVNREVLDQVERGY 482 +F++ SDVWSFG++L EL T K + P P M+ +++ ++ Sbjct: 209 ESKFSVASDVWSFGVVLYELFTYIEKSKSP-PAEFMRMIGNDKQGQMIVFHLIELLKNNG 267 Query: 483 RMPCPPECPESLHDLMCQCWRKEPEERPTFEYL 515 R+P P CP+ ++ +M +CW +RP+F L Sbjct: 268 RLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 300 >3VHK-A nrPDB Length = 368 Score = 132 bits (332), Expect = 4e-31, Method: Compositional matrix adjust. Identities = 68/172 (39%), Positives = 98/172 (56%), Gaps = 2/172 (1%) Query: 360 YLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI-EDNE 418 +L L L+ + Q+A GM ++ +HRDL A NIL+ E V K+ DFGLAR I +D + Sbjct: 196 FLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPD 255 Query: 419 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQ 477 Y + A+ P+KW APE +TI+SDVWSFG+LL E+ + G PYPG+ ++ E + Sbjct: 256 YVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRR 315 Query: 478 VERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 ++ G RM P ++ M CW EP +RPTF L L + + Q Sbjct: 316 LKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQ 367 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 30/110 (27%), Positives = 55/110 (50%), Gaps = 11/110 (10%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR------VAIKTLKPGTMSPE--AFLQEA 314 WE PR+ L+L LG+G FG+V G + VA+K LK G E A + E Sbjct: 24 WEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSEL 83 Query: 315 QVMKKLRHE-KLVQLYAVVSEE--PIYIVTEYMSKGSLLDFLKGETGKYL 361 +++ + H +V L ++ P+ ++ E+ G+L +L+ + +++ Sbjct: 84 KILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFV 133 >3DTC-A nrPDB Length = 271 Score = 128 bits (322), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 94/269 (34%), Positives = 133/269 (49%), Gaps = 30/269 (11%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPG-----TMSPEAFLQEAQVMK 318 EI L LE +G G FG+V+ W G VA+K + + + E QEA++ Sbjct: 3 EIDFAELTLEEIIGIGGFGKVYRAFWIGD-EVAVKAARHDPDEDISQTIENVRQEAKLFA 61 Query: 319 KLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQ--LVDMAAQIAS 375 L+H ++ L V +EP + +V E+ G L L G+ R+P LV+ A QIA Sbjct: 62 MLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGK-----RIPPDILVNWAVQIAR 116 Query: 376 GMAYVER---MNYVHRDLRAANILVGE--------NLVCKVADFGLARLIEDNEYTARQG 424 GM Y+ + +HRDL+++NIL+ + N + K+ DFGLAR + T + Sbjct: 117 GMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR---EWHRTTKMS 173 Query: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YR 483 A W APE F+ SDVWS+G+LL EL T G VP+ G+ V V Sbjct: 174 AAGAYAWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMNKLA 232 Query: 484 MPCPPECPESLHDLMCQCWRKEPEERPTF 512 +P P CPE LM CW +P RP+F Sbjct: 233 LPIPSTCPEPFAKLMEDCWNPDPHSRPSF 261 >5HVK-A nrPDB Length = 315 Score = 128 bits (321), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 96/282 (34%), Positives = 140/282 (49%), Gaps = 39/282 (13%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTRVAI--KTLKPGTMSPEAFLQEAQVMKKLRHE 323 P + + EV LG+GCFG+ T T V + + ++ + FL+E +VM+ L H Sbjct: 13 PSDLIHGEV-LGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHP 71 Query: 324 KLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +++ V+ ++ + +TEY+ G+L +K +Y Q V A IASGMAY+ Sbjct: 72 NVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQY-PWSQRVSFAKDIASGMAYLHS 130 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIK------------ 430 MN +HR+L + N LV EN VADFGLARL+ D E T +G + K Sbjct: 131 MNIIHRNLNSHNCLVRENKNVVVADFGLARLMVD-EKTQPEGLRSLKKPDRKKRYTVVGN 189 Query: 431 --WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYP----------GMVNREVLDQV 478 W APE + K DV+SFGI+L E+ GRV G+ R LD+ Sbjct: 190 PYWMAPEMINGRSYDEKVDVFSFGIVLCEII--GRVNADPDYLPRTMDFGLNVRGFLDRY 247 Query: 479 ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 CPP CP S + +C +PE+RP+F L+ +LE Sbjct: 248 -------CPPNCPPSFFPITVRCCDLDPEKRPSFVKLEHWLE 282 >4UY9-A nrPDB Length = 323 Score = 128 bits (321), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 94/269 (34%), Positives = 133/269 (49%), Gaps = 30/269 (11%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPG-----TMSPEAFLQEAQVMK 318 EI L LE +G G FG+V+ W G VA+K + + + E QEA++ Sbjct: 5 EIDFAELTLEEIIGIGGFGKVYRAFWIGD-EVAVKAARHDPDEDISQTIENVRQEAKLFA 63 Query: 319 KLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQ--LVDMAAQIAS 375 L+H ++ L V +EP + +V E+ G L L G+ R+P LV+ A QIA Sbjct: 64 MLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVLSGK-----RIPPDILVNWAVQIAR 118 Query: 376 GMAYVER---MNYVHRDLRAANILVGE--------NLVCKVADFGLARLIEDNEYTARQG 424 GM Y+ + +HRDL+++NIL+ + N + K+ DFGLAR + T + Sbjct: 119 GMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR---EWHRTTKMS 175 Query: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YR 483 A W APE F+ SDVWS+G+LL EL T G VP+ G+ V V Sbjct: 176 AAGTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMNKLA 234 Query: 484 MPCPPECPESLHDLMCQCWRKEPEERPTF 512 +P P CPE LM CW +P RP+F Sbjct: 235 LPIPSTCPEPFAKLMEDCWNPDPHSRPSF 263 >3HNG-A nrPDB Length = 360 Score = 127 bits (320), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 62/163 (38%), Positives = 95/163 (58%), Gaps = 2/163 (1%) Query: 361 LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDN-EY 419 + + L+ + Q+A GM ++ +HRDL A NIL+ EN V K+ DFGLAR I N +Y Sbjct: 196 ITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDY 255 Query: 420 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQV 478 + + P+KW APE+ ++ KSDVWS+G+LL E+ + G PYPG+ ++ + ++ Sbjct: 256 VRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRL 315 Query: 479 ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLED 521 G RM P ++ +M CW ++P+ERP F L L D Sbjct: 316 REGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGD 358 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 36/116 (31%), Positives = 60/116 (51%), Gaps = 13/116 (11%) Query: 254 QTQGLAKDA--WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR------VAIKTLKPGTM 305 Q + L DA WE RE L+L LG+G FG+V + G + VA+K LK G Sbjct: 11 QCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGAT 70 Query: 306 SPE--AFLQEAQVMKKLRHE-KLVQLYAVVSEE--PIYIVTEYMSKGSLLDFLKGE 356 + E A + E +++ + H +V L +++ P+ ++ EY G+L ++LK + Sbjct: 71 ASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSK 126 >6AMW-A nrPDB Length = 255 Score = 116 bits (290), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 70/190 (36%), Positives = 108/190 (56%), Gaps = 13/190 (6%) Query: 79 AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVN-NTEGDWWLAHSLSTGQTGYIPS 137 AGP FVALYD+ + + LS KGE+L+++ N G+W A + + G++PS Sbjct: 75 AGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEW--AEAQTKNGQGWVPS 132 Query: 138 NYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNA 197 NY+ P +S++ WY G ++R +E LL + N G+FLVRESE++ G +S+ Sbjct: 133 NYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISL----RY 186 Query: 198 KGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQ 256 +G V HY+I G Y++S ++FN+L +LV ++S ADGL L P +KP Sbjct: 187 EG-RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVY 245 Query: 257 GLAK--DAWE 264 G++ D WE Sbjct: 246 GVSPNYDKWE 255 >4M4Z-A nrPDB Length = 170 Score = 110 bits (275), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 65/162 (40%), Positives = 92/162 (56%), Gaps = 5/162 (3%) Query: 87 TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSI 146 T VAL + + +LS + GE L IV+ +GDWW S +G+ IPS +VA Sbjct: 12 ATAVALGSFPAGGPAELSLRLGEPLTIVSE-DGDWWTVLSEVSGREYNIPSVHVAK---- 66 Query: 147 QAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYK 206 + W + ++R ++E LLL NP G FL+RES+T +G+Y LSV A ++HY+ Sbjct: 67 VSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYR 126 Query: 207 IRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC 248 I LD+G YI+ R F SLQ LV +YS+ AD +C L C Sbjct: 127 IHCLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPC 168 >4GS6-A nrPDB Length = 315 Score = 109 bits (273), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 86/282 (30%), Positives = 136/282 (48%), Gaps = 19/282 (6%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324 I + + +E +G+G FG V W VAIK ++ + +AF+ E + + ++ H Sbjct: 6 IDYKEIEVEEVVGRGAFGVVCKAKWRAKD-VAIKQIESESER-KAFIVELRQLSRVNHPN 63 Query: 325 LVQLYAVVSEEPIYIVTEYMSKGSLLDFLKG-ETGKYLRLPQLVDMAAQIASGMAYVERM 383 +V+LY P+ +V EY GSL + L G E Y + Q + G+AY+ M Sbjct: 64 IVKLYGACLN-PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 122 Query: 384 N---YVHRDLRAANIL-VGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 +HRDL+ N+L V V K+ DFG A I+ + + A W APE Sbjct: 123 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAA----WMAPEVFEG 178 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYP--GMVNREVLDQVERGYRMPCPPECPESLHDL 497 ++ K DV+S+GI+L E+ T+ R P+ G ++ V G R P P+ + L Sbjct: 179 SNYSEKCDVFSWGIILWEVITR-RKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESL 237 Query: 498 MCQCWRKEPEERPTFE---YLQAFLEDYFT-STEPQYQPGEN 535 M +CW K+P +RP+ E + L YF + EP P ++ Sbjct: 238 MTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQH 279 >4YFF-A nrPDB Length = 311 Score = 108 bits (271), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 80/264 (30%), Positives = 128/264 (48%), Gaps = 17/264 (6%) Query: 276 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA----FLQEAQVMKKLRHEKLVQLYAV 331 +G G FG+V+ G VAIK + T ++ F +E ++ +L H ++Q Sbjct: 50 IGSGSFGKVYKGRCRNKI-VAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGA 108 Query: 332 VSEEP--IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN--YVH 387 +P IVT+Y+S GSL L E + L L + +A +A GM Y+ + +H Sbjct: 109 CLNDPSQFAIVTQYISGGSLFSLLH-EQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIH 167 Query: 388 RDLRAANILVGENLVCKVADFGLARLIE--DNEYTARQGAKFPIKWTAPEA-ALYGRFTI 444 RDL + NIL+ E+ VADFG +R ++ D + +Q ++W APE R+TI Sbjct: 168 RDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGN--LRWMAPEVFTQCTRYTI 225 Query: 445 KSDVWSFGILLTELTTKGRVPYPGMV-NREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503 K+DV+S+ + L E+ T G +P+ + D R P P+ + L+ + W Sbjct: 226 KADVFSYALCLWEILT-GEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIRGWN 284 Query: 504 KEPEERPTFEYLQAFLEDYFTSTE 527 PE RP F + LE+ + E Sbjct: 285 ACPEGRPEFSEVVMKLEECLCNIE 308 >2ABL-A nrPDB Length = 163 Score = 108 bits (270), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 65/171 (38%), Positives = 99/171 (57%), Gaps = 10/171 (5%) Query: 80 GPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVN-NTEGDWWLAHSLSTGQTGYIPSN 138 GP FVALYD+ + + LS KGE+L+++ N G+W A + GQ G++PSN Sbjct: 2 GPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT-KNGQ-GWVPSN 59 Query: 139 YVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 198 Y+ P +S++ WY G ++R +E LL + N G+FLVRESE++ G +S+ + Sbjct: 60 YITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISL----RYE 113 Query: 199 GLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCP 249 G V HY+I G Y++S ++FN+L +LV ++S ADGL L P Sbjct: 114 G-RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAP 163 >4NEU-A nrPDB Length = 333 Score = 108 bits (269), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 84/274 (30%), Positives = 131/274 (47%), Gaps = 27/274 (9%) Query: 275 KLGQGCFGEVWMGTWNGTTRVAIKTLKPG---TMSPEAFLQEAQVMKKLRHEKLVQLYAV 331 +L G FG+V + + +KT+ G EA L+EA++M +LRH ++V+L V Sbjct: 31 ELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGV 90 Query: 332 VSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDL 390 + EE Y +V EYM KG+L+ LK E L + + + +I GM Y+ +H+DL Sbjct: 91 IIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL--EIIEGMCYLHGKGVIHKDL 148 Query: 391 RAANILVGENLVCKVADFGLARLI--------EDNEY-----TARQGAKFPIKWTAPEAA 437 + NILV + K+AD GLA E NE TA++ + + APE Sbjct: 149 KPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGG-TLYYMAPEHL 207 Query: 438 --LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE----CP 491 + + T KSDV+SF ++L + + PY + + L + P + CP Sbjct: 208 NDVNAKPTEKSDVYSFAVVLWAIFA-NKEPYENAICEQQLIMCIKSGNRPDVDDITEYCP 266 Query: 492 ESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTS 525 + LM CW PE RPTF ++ ++ S Sbjct: 267 REIISLMKLCWEANPEARPTFPGIEEKFRPFYLS 300 >5UIU-A nrPDB Length = 323 Score = 106 bits (265), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 85/277 (30%), Positives = 137/277 (49%), Gaps = 33/277 (11%) Query: 275 KLGQGCFGEVWMGTWNGTTRVAIKTLKPGT-MSPE----AFLQEAQVMKKLRHEKLVQLY 329 K+G+G FG V+ G N TT VA+K L ++ E F QE +VM K +HE LV+L Sbjct: 54 KMGEGGFGVVYKGYVNNTT-VAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELL 112 Query: 330 AVVSE-EPIYIVTEYMSKGSLLDFLKGETGK-----YLRLPQLVDMAAQIASGMAYVERM 383 S+ + + +V YM GSLLD L G ++R +A A+G+ ++ Sbjct: 113 GFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCK----IAQGAANGINFLHEN 168 Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKF-PIKWTAPEAALYGRF 442 +++HRD+++ANIL+ E K++DFGLAR E T + APE AL G Sbjct: 169 HHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPE-ALRGEI 227 Query: 443 TIKSDVWSFGILLTELTT------KGRVP--------YPGMVNREVLDQVERGYRMPCPP 488 T KSD++SFG++L E+ T + R P + + D +++ Sbjct: 228 TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMN-DADS 286 Query: 489 ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTS 525 E+++ + QC ++ +RP + +Q L++ S Sbjct: 287 TSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 323 >4TPT-A nrPDB Length = 303 Score = 105 bits (262), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 84/271 (30%), Positives = 127/271 (46%), Gaps = 31/271 (11%) Query: 276 LGQGCFGEVWMGTWNGTTRVAI--KTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVV- 332 LG+G FG+ T T +V + + ++ + + FL E +VM+ L H +++ V+ Sbjct: 8 LGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLY 67 Query: 333 SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRA 392 ++ + ++TEY+ G+L DFL+ Q V A IASGMAY+ M +HRDL + Sbjct: 68 KDKKLNLLTEYIEGGTLKDFLRSMDP--FPWQQKVRFAKGIASGMAYLHSMCIIHRDLNS 125 Query: 393 ANILVGENLVCKVADFGLARLIED-------------------NEYTARQGAKFPIKWTA 433 N L+ + VADFGL+RLI + N+ R W A Sbjct: 126 HNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMA 185 Query: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRV-PYPGMVNREVLD---QVERGYRMPCPPE 489 PE + D++SFGI+L E+ G+V P + R LD V+ + P + Sbjct: 186 PEMLNGKSYDETVDIFSFGIVLCEII--GQVYADPDCLPR-TLDFGLNVKLFWEKFVPTD 242 Query: 490 CPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 CP + L C R EPE RP F L+ E Sbjct: 243 CPPAFFPLAAICCRLEPESRPAFSKLEDSFE 273 >4QMW-A nrPDB Length = 310 Score = 101 bits (252), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 82/267 (30%), Positives = 126/267 (47%), Gaps = 13/267 (4%) Query: 253 PQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKT--LKPGTMSPEA 309 P Q L D P E K+G+G FGEV+ G N T +V AIK L+ E Sbjct: 18 PGMQNLKAD----PEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIED 73 Query: 310 FLQEAQVMKKLRHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD 368 QE V+ + + + Y + + + ++I+ EY+ GS LD L E G L Q+ Sbjct: 74 IQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLL--EPGP-LDETQIAT 130 Query: 369 MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFP 428 + +I G+ Y+ +HRD++AAN+L+ E+ K+ADFG+A + D + P Sbjct: 131 ILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTP 190 Query: 429 IKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP 488 W APE + K+D+WS GI EL +G P+ + +VL + + Sbjct: 191 F-WMAPEVIKQSAYDSKADIWSLGITAIEL-ARGEPPHSELHPMKVLFLIPKNNPPTLEG 248 Query: 489 ECPESLHDLMCQCWRKEPEERPTFEYL 515 + L + + C KEP RPT + L Sbjct: 249 NYSKPLKEFVEACLNKEPSFRPTAKEL 275 >5XD6-A nrPDB Length = 305 Score = 101 bits (252), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 68/204 (33%), Positives = 106/204 (51%), Gaps = 17/204 (8%) Query: 276 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE 335 +G+G +G V+ G AIK L + FL + ++ +LR E +V L + Sbjct: 30 IGEGSYGRVFYGILKSGKAAAIKKLDSSKQPDQEFLAQVSMVSRLRQENVVALLGYCVDG 89 Query: 336 PIYIVT-EYMSKGSLLDFLKG-------ETGKYLRLPQLVDMAAQIASGMAYV-ERMN-- 384 P+ ++ EY GSL D L G + G L Q V +A A G+ Y+ E+ N Sbjct: 90 PLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAARGLEYLHEKANPH 149 Query: 385 YVHRDLRAANILVGENLVCKVADFGLARLIEDNE---YTARQGAKFPIKWTAPEAALYGR 441 +HRD++++N+L+ ++ V K+ADF L+ D ++ R F + APE A+ G Sbjct: 150 VIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTF--GYHAPEYAMTGT 207 Query: 442 FTIKSDVWSFGILLTELTTKGRVP 465 + KSDV+SFG++L EL T GR P Sbjct: 208 LSTKSDVYSFGVVLLELLT-GRKP 230 >2QNJ-A nrPDB Length = 328 Score = 99.8 bits (247), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 73/227 (32%), Positives = 120/227 (52%), Gaps = 22/227 (9%) Query: 271 RLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP---EAFLQEAQVMKKLRHEKLV 326 RL +G+G F +V + T R VAIK + ++P + +E ++MK L H +V Sbjct: 15 RLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIV 74 Query: 327 QLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 +L+ V+ +E+ +Y++ EY S G + D+L G+ ++ + QI S + Y + Sbjct: 75 KLFEVIETEKTLYLIMEYASGGEVFDYLVAH-GR-MKEKEARSKFRQIVSAVQYCHQKRI 132 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445 VHRDL+A N+L+ ++ K+ADFG + NE+T G K +P A F K Sbjct: 133 VHRDLKAENLLLDADMNIKIADFGFS-----NEFTV--GGKLDTFCGSPPYAAPELFQGK 185 Query: 446 S------DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMP 485 DVWS G++L L + G +P+ G +E+ ++V RG YR+P Sbjct: 186 KYDGPEVDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGKYRIP 231 >5ES1-A nrPDB Length = 328 Score = 99.4 bits (246), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 80/259 (30%), Positives = 130/259 (50%), Gaps = 28/259 (10%) Query: 271 RLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP---EAFLQEAQVMKKLRHEKLV 326 RL +G+G F +V + T R VAIK + ++P + +E ++MK L H +V Sbjct: 18 RLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIV 77 Query: 327 QLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 +L+ V+ +E+ +Y+V EY S G + D+L G+ ++ + QI S + Y + N Sbjct: 78 KLFEVIETEKTLYLVMEYASAGEVFDYLVSH-GR-MKEKEARAKFRQIVSAVHYCHQKNI 135 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445 VHRDL+A N+L+ K+ADFG + NE+T G+K +P A F K Sbjct: 136 VHRDLKAENLLLDAEANIKIADFGFS-----NEFTL--GSKLDTFCGSPPYAAPELFQGK 188 Query: 446 S------DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMP--CPPECPESLHD 496 D+WS G++L L + G +P+ G +E+ ++V RG YR+P +C L Sbjct: 189 KYDGPEVDIWSLGVILYTLVS-GSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRR 247 Query: 497 LMCQCWRKEPEERPTFEYL 515 + P +R T E + Sbjct: 248 FLVL----NPAKRCTLEQI 262 >2HAK-A nrPDB Length = 328 Score = 99.4 bits (246), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 73/227 (32%), Positives = 121/227 (53%), Gaps = 22/227 (9%) Query: 271 RLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP---EAFLQEAQVMKKLRHEKLV 326 RL+ +G+G F +V + T R VA+K + ++P + +E ++MK L H +V Sbjct: 18 RLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIV 77 Query: 327 QLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 +L+ V+ +E+ +Y+V EY S G + D+L G+ ++ + QI S + Y + Sbjct: 78 KLFEVIETEKTLYLVMEYASGGEVFDYLVAH-GR-MKEKEARAKFRQIVSAVQYCHQKYI 135 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445 VHRDL+A N+L+ ++ K+ADFG + NE+T G K +P A F K Sbjct: 136 VHRDLKAENLLLDGDMNIKIADFGFS-----NEFTV--GNKLDTFCGSPPYAAPELFQGK 188 Query: 446 S------DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMP 485 DVWS G++L L + G +P+ G +E+ ++V RG YR+P Sbjct: 189 KYDGPEVDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGKYRIP 234 >6C9D-A nrPDB Length = 459 Score = 99.0 bits (245), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 73/227 (32%), Positives = 121/227 (53%), Gaps = 22/227 (9%) Query: 271 RLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP---EAFLQEAQVMKKLRHEKLV 326 RL+ +G+G F +V + T R VA+K + ++P + +E ++MK L H +V Sbjct: 24 RLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIV 83 Query: 327 QLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 +L+ V+ +E+ +Y+V EY S G + D+L G+ ++ + QI S + Y + Sbjct: 84 KLFEVIETEKTLYLVMEYASGGEVFDYLVAH-GR-MKEKEARAKFRQIVSAVQYCHQKYI 141 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445 VHRDL+A N+L+ ++ K+ADFG + NE+T G K +P A F K Sbjct: 142 VHRDLKAENLLLDGDMNIKIADFGFS-----NEFTV--GNKLDEFCGSPPYAAPELFQGK 194 Query: 446 S------DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMP 485 DVWS G++L L + G +P+ G +E+ ++V RG YR+P Sbjct: 195 KYDGPEVDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGKYRIP 240 >4MVF-A nrPDB Length = 506 Score = 98.2 bits (243), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 70/217 (32%), Positives = 115/217 (52%), Gaps = 14/217 (6%) Query: 272 LEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTM-SPEAFLQEAQVMKKLRHEKLVQLY 329 ++ KLGQG +G V+ G T ++ AIK K + + F QE ++MKKL H +V+LY Sbjct: 61 IDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDHPNIVKLY 120 Query: 330 AVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 + IY++ E S L D + E G + + QI S + Y+ +N VHR Sbjct: 121 ETYENDNYIYLIMELCSGRELFDSII-ENGSFTE-KNAATIMKQIFSAIFYLHSLNIVHR 178 Query: 389 DLRAANILV---GENLVCKVADFGLARLIEDNEY-TARQGAKFPIKWTAPEAALYGRFTI 444 DL+ N L ++ + K+ DFGL++ + E+ T + G + + AP+ L G++ Sbjct: 179 DLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPY---YVAPQ-VLDGKYDK 234 Query: 445 KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481 K D+WS G+++ L G P+ G + EVL +V++G Sbjct: 235 KCDIWSSGVIMYTLLC-GYPPFYGDTDNEVLKKVKKG 270 >3IS5-A nrPDB Length = 285 Score = 98.2 bits (243), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 81/251 (32%), Positives = 130/251 (51%), Gaps = 21/251 (8%) Query: 275 KLGQGCFGEVWM--GTWNGTTRVAIKTL-KPGTMSP-EAFLQEAQVMKKLRHEKLVQLYA 330 KLG G FG+V + +G RV IKT+ K + P E E +V+K L H +++++ Sbjct: 29 KLGSGAFGDVHLVEERSSGLERV-IKTINKDRSQVPMEQIEAEIEVLKSLDHPNIIKIFE 87 Query: 331 VVSE-EPIYIVTEYMSKGSLLDFLKGET--GKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 V + +YIV E G LL+ + GK L + ++ Q+ + +AY + VH Sbjct: 88 VFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFHSQHVVH 147 Query: 388 RDLRAANILVGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR-FT 443 +DL+ NIL + + K+ DFGLA L + +E++ A + APE ++ R T Sbjct: 148 KDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHST--NAAGTALYMAPE--VFKRDVT 203 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV---ERGYRMPCPPECPESLHDLMCQ 500 K D+WS G+++ L T G +P+ G EV + E Y + C P P+++ DL+ Q Sbjct: 204 FKCDIWSAGVVMYFLLT-GCLPFTGTSLEEVQQKATYKEPNYAVECRPLTPQAV-DLLKQ 261 Query: 501 CWRKEPEERPT 511 K+PE RP+ Sbjct: 262 MLTKDPERRPS 272 >4FZF-B nrPDB Length = 283 Score = 97.8 bits (242), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 75/250 (30%), Positives = 116/250 (46%), Gaps = 9/250 (3%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKT--LKPGTMSPEAFLQEAQVMKKLRH 322 P E ++G+G FGEV+ G N T +V AIK L+ E QE V+ + Sbjct: 6 PEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS 65 Query: 323 EKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 + + Y + + ++I+ EY+ GS LD L+ G + Q+ M +I G+ Y+ Sbjct: 66 SYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA--GPFDEF-QIATMLKEILKGLDYLH 122 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 +HRD++AAN+L+ E K+A FG+A + D + P W APE Sbjct: 123 SEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPF-WMAPEVIQQSA 181 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 501 + K+D+WS GI EL KG P M VL + + + +S + + C Sbjct: 182 YDSKADIWSLGITAIEL-AKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDAC 240 Query: 502 WRKEPEERPT 511 K+P RPT Sbjct: 241 LNKDPSFRPT 250 >3DAK-A nrPDB Length = 290 Score = 97.4 bits (241), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 75/285 (26%), Positives = 127/285 (44%), Gaps = 49/285 (17%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWN-GTTRVAIK--TLKPGTMSPEAFLQEAQVMKK 319 W I R+ L+ +G G V +VAIK L+ S + L+E Q M + Sbjct: 5 WSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQ 64 Query: 320 LRHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGK------YLRLPQLVDMAAQ 372 H +V Y + V ++ +++V + +S GS+LD +K K L + + + Sbjct: 65 CHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILRE 124 Query: 373 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIK-- 430 + G+ Y+ + +HRD++A NIL+GE+ ++ADFG++ + R + Sbjct: 125 VLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGT 184 Query: 431 --WTAPEAALYGR-FTIKSDVWSFGILLTELTTKGRVPY--------------------- 466 W APE R + K+D+WSFGI EL T G PY Sbjct: 185 PCWMAPEVMEQVRGYDFKADIWSFGITAIELAT-GAAPYHKYPPMKVLMLTLQNDPPSLE 243 Query: 467 PGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPT 511 G+ ++E+L + + +R ++ C +K+PE+RPT Sbjct: 244 TGVQDKEMLKKYGKSFR------------KMISLCLQKDPEKRPT 276 >5DBX-A nrPDB Length = 328 Score = 95.9 bits (237), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 78/285 (27%), Positives = 128/285 (44%), Gaps = 49/285 (17%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWN-GTTRVAIK--TLKPGTMSPEAFLQEAQVMKK 319 W I R++ L+ +G G V RVAIK L+ S + L+E Q M + Sbjct: 6 WPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQ 65 Query: 320 LRHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLK-----GE-TGKYLRLPQLVDMAAQ 372 H +V Y + V ++ +++V + +S GS+LD +K GE L + + + Sbjct: 66 CSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKE 125 Query: 373 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIK-- 430 + G+ Y+ R +HRDL+A NIL+GE+ ++ADFG++ + R + Sbjct: 126 VLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGT 185 Query: 431 --WTAPEAALYGR-FTIKSDVWSFGILLTELTTKGRVPY--------------------- 466 W APE R + K+D+WSFGI EL T G PY Sbjct: 186 PCWMAPEVMEQVRGYDFKADMWSFGITAIELAT-GAAPYHKYPPMKVLMLTLQNDPPTLE 244 Query: 467 PGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPT 511 G+ ++E++ + + +R L+ C +K+P +RPT Sbjct: 245 TGVEDKEMMKKYGKSFR------------KLLSLCLQKDPSKRPT 277 >3LIJ-A nrPDB Length = 494 Score = 95.5 bits (236), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 78/253 (30%), Positives = 129/253 (50%), Gaps = 27/253 (10%) Query: 275 KLGQGCFGEVWMGTWNGTTRV--AIKTLKPGTMSPEA---FLQEAQVMKKLRHEKLVQLY 329 KLG G +GEV + + T V AIK ++ ++S + L+E V+K L H +++LY Sbjct: 44 KLGSGAYGEVLL-CRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHPNIMKLY 102 Query: 330 AVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA---QIASGMAYVERMNY 385 ++ Y+V E G L D E ++ + VD A Q+ SG+ Y+ + N Sbjct: 103 DFFEDKRNYYLVMECYKGGELFD----EIIHRMKFNE-VDAAVIIKQVLSGVTYLHKHNI 157 Query: 386 VHRDLRAANILV---GENLVCKVADFGLARLIEDN-EYTARQGAKFPIKWTAPEAALYGR 441 VHRDL+ N+L+ ++ + K+ DFGL+ + E+ + R G + + APE L + Sbjct: 158 VHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAY---YIAPE-VLRKK 213 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE---CPESLHDLM 498 + K DVWS G++L L G P+ G ++E+L +VE+G PE E DL+ Sbjct: 214 YDEKCDVWSIGVILFILLA-GYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVSEGAKDLI 272 Query: 499 CQCWRKEPEERPT 511 Q + + + R + Sbjct: 273 KQMLQFDSQRRIS 285 >4I6B-A nrPDB Length = 308 Score = 95.5 bits (236), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 73/256 (28%), Positives = 116/256 (45%), Gaps = 15/256 (5%) Query: 276 LGQGCFGEVWMGTWNGTTRVAIKTLKPGT-----MSPEAFLQEAQVMKKLRHEKLVQLYA 330 LG+G F + + T +V + P + E +E ++ + L H+ +VQ Y Sbjct: 36 LGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHKHVVQFYH 95 Query: 331 VVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 + E IYI+ EY S+ S+ LK K L P++ QI SG+ Y+ +HRD Sbjct: 96 YFEDKENIYILLEYCSRRSMAHILKAR--KVLTEPEVRYYLRQIVSGLKYLHEQEILHRD 153 Query: 390 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 449 L+ N + E++ KV DFGLA +E E+ R P + +PE +SD+W Sbjct: 154 LKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTP-NYLSPEVLNKQGHGAESDIW 212 Query: 450 SFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESLHDLMCQCWRKEPEE 508 + G ++ + GR P+ +E + E Y MP P L+ K PE+ Sbjct: 213 ALGCVMYTMLL-GRPPFETTNLKETYRSIREARYTMPSSLLAPAK--HLIASMLSKNPED 269 Query: 509 RPTFEYLQAFLEDYFT 524 RP+ + D+FT Sbjct: 270 RPSLD--DIIRHDFFT 283 >5KZ7-A nrPDB Length = 346 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 78/257 (30%), Positives = 128/257 (49%), Gaps = 28/257 (10%) Query: 271 RLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTM---SPEAFLQEAQVMKKLRHEKLV 326 RL +G+G F +V + T + VA+K + + S + +E ++MK L H +V Sbjct: 36 RLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIV 95 Query: 327 QLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 +L+ V+ +E+ +Y+V EY S G + D+L G+ ++ + QI S + Y + Sbjct: 96 KLFEVIETEKTLYLVMEYASGGEVFDYLVAH-GR-MKEKEARAKFRQIVSAVQYCHQKFI 153 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445 VHRDL+A N+L+ ++ K+ADFG + NE+T G K +P A F K Sbjct: 154 VHRDLKAENLLLDADMNIKIADFGFS-----NEFTF--GNKLDTFCGSPPYAAPELFQGK 206 Query: 446 S------DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMP--CPPECPESLHD 496 DVWS G++L L + G +P+ G +E+ ++V RG YR+P +C L Sbjct: 207 KYDGPEVDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKK 265 Query: 497 LMCQCWRKEPEERPTFE 513 + P +R T E Sbjct: 266 FLIL----NPSKRGTLE 278 >4F0G-A nrPDB Length = 287 Score = 94.4 bits (233), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 85/276 (30%), Positives = 132/276 (47%), Gaps = 46/276 (16%) Query: 270 LRLEVKLGQGCFGEVWMGTW-NGTTRVAIKTLKPGTMSPEA--------FLQEAQVMKKL 320 + E ++G+G FG V G + VAIK+L G E F +E +M L Sbjct: 21 IEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIMSNL 80 Query: 321 RHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFL--KGETGKY-LRLPQLVDMAAQIASGM 377 H +V+LY ++ P +V E++ G L L K K+ ++L ++D IA G+ Sbjct: 81 NHPNIVKLYGLMHNPP-RMVMEFVPCGDLYHRLLDKAHPIKWSVKLRLMLD----IALGI 135 Query: 378 AYVERMN--YVHRDLRAANILV---GENL-VC-KVADFGLARLIEDNEYTARQGAKFPIK 430 Y++ N VHRDLR+ NI + EN VC KVADFGL++ + G + Sbjct: 136 EYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQ----QSVHSVSGLLGNFQ 191 Query: 431 WTAPE--AALYGRFTIKSDVWSFGILLTELTTK---------GRVPYPGMVNREVLDQVE 479 W APE A +T K+D +SF ++L + T G++ + M+ E Sbjct: 192 WMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREE------ 245 Query: 480 RGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYL 515 G R P +CP L +++ CW +P++RP F Y+ Sbjct: 246 -GLRPTIPEDCPPRLRNVIELCWSGDPKKRPHFSYI 280 >4APC-A nrPDB Length = 350 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 71/262 (27%), Positives = 123/262 (46%), Gaps = 13/262 (4%) Query: 270 LRLEVKLGQGCFGEVWM--GTWNGTTRVAIKTLKPGTMSP---EAFLQEAQVMKKLRHEK 324 +RL+ K+G+G FG+ + T +G V IK + MS E +E V+ ++H Sbjct: 27 VRLQ-KIGEGSFGKAILVKSTEDGRQYV-IKEINISRMSSKEREESRREVAVLANMKHPN 84 Query: 325 LVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 +VQ E +YIV +Y G L + + G + Q++D QI + +V Sbjct: 85 IVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDR 144 Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443 +HRD+++ NI + ++ ++ DFG+AR++ AR P + +PE + Sbjct: 145 KILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPY-YLSPEICENKPYN 203 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503 KSD+W+ G +L EL T G + VL ++ G P L L+ Q ++ Sbjct: 204 NKSDIWALGCVLYELCTLKHAFEAGSMKNLVL-KIISGSFPPVSLHYSYDLRSLVSQLFK 262 Query: 504 KEPEERPTFEYLQAFLEDYFTS 525 + P +RP+ + + LE F + Sbjct: 263 RNPRDRPS---VNSILEKGFIA 281 >4REW-A nrPDB Length = 540 Score = 94.0 bits (232), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 67/199 (33%), Positives = 107/199 (53%), Gaps = 14/199 (7%) Query: 276 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFL----QEAQVMKKLRHEKLVQLYA 330 LG G FG+V +G T +VA+K L + + +E Q +K RH +++LY Sbjct: 14 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 73 Query: 331 VVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 V+S I++V EY+S G L D++ + G+ L + + QI SG+ Y R VHRD Sbjct: 74 VISTPSDIFMVMEYVSGGELFDYI-CKNGR-LDEKESRRLFQQILSGVDYCHRHMVVHRD 131 Query: 390 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI--KSD 447 L+ N+L+ ++ K+ADFGL+ ++ D E+ R P + APE + GR + D Sbjct: 132 LKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSP-NYAAPE-VISGRLYAGPEVD 188 Query: 448 VWSFGILLTELTTKGRVPY 466 +WS G++L L G +P+ Sbjct: 189 IWSSGVILYALLC-GTLPF 206 >5EZV-A nrPDB Length = 560 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 80/273 (29%), Positives = 129/273 (47%), Gaps = 29/273 (10%) Query: 276 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFL----QEAQVMKKLRHEKLVQLYA 330 LG G FG+V +G T +VA+K L + + +E Q +K RH +++LY Sbjct: 36 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 95 Query: 331 VVSE-EPIYIVTEYMSKGSLLDFL----KGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 V+S ++V EY+S G L D++ + E + RL Q QI S + Y R Sbjct: 96 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ------QILSAVDYCHRHMV 149 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI- 444 VHRDL+ N+L+ ++ K+ADFGL+ ++ D E+ R P + APE + GR Sbjct: 150 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSP-NYAAPE-VISGRLYAG 206 Query: 445 -KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503 + D+WS G++L L G +P+ + ++ RG P S+ L+ + Sbjct: 207 PEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNRSVATLLMHMLQ 264 Query: 504 KEPEERPTF------EYLQAFLEDYFTSTEPQY 530 +P +R T E+ + L Y +P Y Sbjct: 265 VDPLKRATIKDIREHEWFKQDLPSYLFPEDPSY 297 >4CFF-A nrPDB Length = 571 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 80/273 (29%), Positives = 129/273 (47%), Gaps = 29/273 (10%) Query: 276 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFL----QEAQVMKKLRHEKLVQLYA 330 LG G FG+V +G T +VA+K L + + +E Q +K RH +++LY Sbjct: 41 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 100 Query: 331 VVSE-EPIYIVTEYMSKGSLLDFL----KGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 V+S ++V EY+S G L D++ + E + RL Q QI S + Y R Sbjct: 101 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ------QILSAVDYCHRHMV 154 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI- 444 VHRDL+ N+L+ ++ K+ADFGL+ ++ D E+ R P + APE + GR Sbjct: 155 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSP-NYAAPE-VISGRLYAG 211 Query: 445 -KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503 + D+WS G++L L G +P+ + ++ RG P S+ L+ + Sbjct: 212 PEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNRSVATLLMHMLQ 269 Query: 504 KEPEERPTF------EYLQAFLEDYFTSTEPQY 530 +P +R T E+ + L Y +P Y Sbjct: 270 VDPLKRATIKDIREHEWFKQDLPSYLFPEDPSY 302 >4CFH-A nrPDB Length = 493 Score = 93.6 bits (231), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 79/269 (29%), Positives = 132/269 (49%), Gaps = 29/269 (10%) Query: 276 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFL----QEAQVMKKLRHEKLVQLYA 330 LG G FG+V +G T +VA+K L + + +E Q +K RH +++LY Sbjct: 41 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 100 Query: 331 VVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 V+S I++V EY+S G L D++ + G+ L + + QI SG+ Y R VHRD Sbjct: 101 VISTPSDIFMVMEYVSGGELFDYI-CKNGR-LDEKESRRLFQQILSGVDYCHRHMVVHRD 158 Query: 390 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI--KSD 447 L+ N+L+ ++ K+ADFGL+ ++ D E+ R P + APE + GR + D Sbjct: 159 LKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSP-NYAAPE-VISGRLYAGPEVD 215 Query: 448 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPC------PPECPESLHDLMCQC 501 +WS G++L L G +P+ D V ++ C P S+ L+ Sbjct: 216 IWSSGVILYALLC-GTLPFDD-------DHVPTLFKKICDGIFYTPQYLNPSVISLLKHM 267 Query: 502 WRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 + +P +R T + ++ ++F P+Y Sbjct: 268 LQVDPMKRATIKDIRE--HEWFKQDLPKY 294 >2XIK-A nrPDB Length = 294 Score = 92.8 bits (229), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 70/241 (29%), Positives = 111/241 (46%), Gaps = 9/241 (3%) Query: 275 KLGQGCFGEVWMGTWNGTTRV-AIKT--LKPGTMSPEAFLQEAQVMKKLRHEKLVQLY-A 330 ++G+G FGEV+ G N T V AIK L+ E QE V+ + + + + + Sbjct: 26 RIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGS 85 Query: 331 VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDL 390 + ++I+ EY+ GS LD LK L + + +I G+ Y+ +HRD+ Sbjct: 86 YLKSTKLWIIMEYLGGGSALDLLKPGP---LEETYIATILREILKGLDYLHSERKIHRDI 142 Query: 391 RAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS 450 +AAN+L+ E K+ADFG+A + D + P W APE + K+D+WS Sbjct: 143 KAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPF-WMAPEVIKQSAYDFKADIWS 201 Query: 451 FGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERP 510 GI EL KG P + VL + + + + + + C K+P RP Sbjct: 202 LGITAIEL-AKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRP 260 Query: 511 T 511 T Sbjct: 261 T 261 >4L00-A nrPDB Length = 304 Score = 92.4 bits (228), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 72/259 (27%), Positives = 117/259 (45%), Gaps = 31/259 (11%) Query: 276 LGQGCFGEVWMGTW------NGTT-----RVAIKTLKPGTMSPE-AFLQEAQVMKKLRHE 323 LG+G ++ GT GT+ +V +K L P AF + A +M+++ H+ Sbjct: 33 LGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHK 92 Query: 324 KLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 +V LY V + I+ E +G LD L P +A Q+AS ++Y+E Sbjct: 93 HIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDK 152 Query: 384 NYVHRDLRAANILVGENLV-------CKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 + VH ++ N+L+ + K++D G+ + +RQ I W APE Sbjct: 153 DLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITV-----LSRQECIERIPWIAPEC 207 Query: 437 ALYGR-FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP--ES 493 + ++ +D WSFG L E+ G +P + + L + ER Y C P P + Sbjct: 208 VEDSKNLSVAADKWSFGTTLWEICYNGEIP----LKDKTLIEKERFYESRCRPVTPSCKE 263 Query: 494 LHDLMCQCWRKEPEERPTF 512 L DLM +C +P +RP F Sbjct: 264 LADLMTRCMNYDPNQRPFF 282 >2YZA-A nrPDB Length = 276 Score = 92.0 bits (227), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 78/267 (29%), Positives = 129/267 (48%), Gaps = 25/267 (9%) Query: 276 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFL----QEAQVMKKLRHEKLVQLYA 330 LG G FG+V +G T +VA+K L + + +E Q +K RH +++LY Sbjct: 19 LGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQ 78 Query: 331 VVSE-EPIYIVTEYMSKGSLLDFL----KGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 V+S ++V EY+S G L D++ + E + RL Q QI S + Y R Sbjct: 79 VISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLFQ------QILSAVDYCHRHMV 132 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI- 444 VHRDL+ N+L+ ++ K+ADFGL+ ++ D E+ R P + APE + GR Sbjct: 133 VHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RDSCGSP-NYAAPE-VISGRLYAG 189 Query: 445 -KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503 + D+WS G++L L G +P+ + ++ RG P S+ L+ + Sbjct: 190 PEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNRSVATLLMHMLQ 247 Query: 504 KEPEERPTFEYLQAFLEDYFTSTEPQY 530 +P +R T + ++ ++F P Y Sbjct: 248 VDPLKRATIKDIRE--HEWFKQDLPSY 272 >1GRI-A nrPDB Length = 217 Score = 91.7 bits (226), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 58/179 (32%), Positives = 97/179 (54%), Gaps = 25/179 (13%) Query: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149 +A YD+++ + +LSFK+G+ L+++N W L+ G+ G+IP NY+ ++ Sbjct: 4 IAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELN-GKDGFIPKNYI----EMKPH 58 Query: 150 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209 W+FGKI R ++E +L+ + G FL+RESE+ G + LSV G +V+H+K+ + Sbjct: 59 PWFFGKIPRAKAEE-MLSKQRHDGAFLIRESESAPGDFSLSVK-----FGNDVQHFKVLR 112 Query: 210 LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRE 268 D G Y +FNSL +LV Y HR T+V Q +D ++P++ Sbjct: 113 -DGAGKYFLWVVKFNSLNELVDY---------HRSTSVSRNQ----QIFLRDIEQVPQQ 157 Score = 48.1 bits (113), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 19/56 (33%), Positives = 35/56 (62%), Gaps = 2/56 (3%) Query: 87 TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAP 142 T AL+D++ + + +L F++G+ + +++N++ +WW GQTG P NYV P Sbjct: 159 TYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWW--KGACHGQTGMFPRNYVTP 212 >6J5U-C nrPDB Length = 426 Score = 91.7 bits (226), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 84/311 (27%), Positives = 138/311 (44%), Gaps = 35/311 (11%) Query: 251 SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----------VAIKTL 300 S P + + + ++ R + LG+G FG V+ G + T+ VA+K L Sbjct: 67 SSPNLKAFTFNELKNATKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQL 126 Query: 301 KP-GTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETG 358 KP G + +L E + +L H LV L +E E +V E+M KGSL + L Sbjct: 127 KPEGFQGHKEWLTEVNYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKGSLENHLFRRGA 186 Query: 359 KYLRLPQLVDMAAQIASGMAYVE--RMNYVHRDLRAANILVGENLVCKVADFGLARL--I 414 + L + +A A G+ ++ + ++RD +AANIL+ + K++DFGLA+ Sbjct: 187 QPLTWAIRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPT 246 Query: 415 EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGR----------- 463 DN + + + + APE GR T KSDV+SFG++L EL + R Sbjct: 247 GDNTHVSTK-VIGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEY 305 Query: 464 ------VPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQA 517 PY G R++ ++ P + + +L QC + + RP + Sbjct: 306 SLVDWATPYLG-DKRKLFRIMDTKLGGQYPQKGAFTAANLALQCLNPDAKLRPKMSEVLV 364 Query: 518 FLEDYFTSTEP 528 LE + +P Sbjct: 365 TLEQLESVAKP 375 >4RGJ-A nrPDB Length = 520 Score = 91.3 bits (225), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 67/237 (28%), Positives = 117/237 (49%), Gaps = 21/237 (8%) Query: 276 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTM----SPEAFLQEAQVMKKLRHEKLVQLYA 330 LG+G FGEV + T AIK + + E+ L+E +++K L H +++LY Sbjct: 68 LGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDHINIMKLYE 127 Query: 331 VVSEEPIY-IVTEYMSKGSLLDFLKGETGKY-LRLPQLVDMAAQIASGMAYVERMNYVHR 388 + Y +V++ + G L D + Y + +++ QI SG+ Y+ + N VHR Sbjct: 128 FFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAARII---KQILSGITYMHKNNVVHR 184 Query: 389 DLRAANILV----GENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI 444 DL+ NIL+ E+++ K+ DFGL+ EY+ + K + L+G + Sbjct: 185 DLKPENILLETKNKEDMIIKIIDFGLSTHF---EYSKKMKDKIGTAYYIAPDVLHGTYDE 241 Query: 445 KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPCPPECPESLHDLM 498 K D+WS G++L L + G P+ G ++L +VE G + +P + + DL+ Sbjct: 242 KCDIWSCGVILYILLS-GCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDKAKDLI 297 >4RED-A nrPDB Length = 351 Score = 91.3 bits (225), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 78/269 (28%), Positives = 131/269 (48%), Gaps = 29/269 (10%) Query: 276 LGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFL----QEAQVMKKLRHEKLVQLYA 330 LG G FG+V +G T VA+K L + + +E Q +K RH +++LY Sbjct: 22 LGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQ 81 Query: 331 VVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 V+S I++V EY+S G L D++ + G+ L + + QI SG+ Y R VHRD Sbjct: 82 VISTPSDIFMVMEYVSGGELFDYI-CKNGR-LDEKESRRLFQQILSGVDYCHRHMVVHRD 139 Query: 390 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI--KSD 447 L+ N+L+ ++ K+ADFGL+ ++ D E+ R P + APE + GR + D Sbjct: 140 LKPENVLLDAHMNAKIADFGLSNMMSDGEFL-RTSCGSP-NYAAPE-VISGRLYAGPEVD 196 Query: 448 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPC------PPECPESLHDLMCQC 501 +WS G++L L G +P+ D V ++ C P S+ L+ Sbjct: 197 IWSSGVILYALLC-GTLPFDD-------DHVPTLFKKICDGIFYTPQYLNPSVISLLKHM 248 Query: 502 WRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 + +P +R + + ++ ++F P+Y Sbjct: 249 LQVDPMKRASIKDIRE--HEWFKQDLPKY 275 >3HZT-A nrPDB Length = 467 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 74/226 (32%), Positives = 114/226 (50%), Gaps = 19/226 (8%) Query: 275 KLGQGCFGEVWM--GTWNGTTRVAIKTLKPGTMSPE----AFLQEAQVMKKLRHEKLVQL 328 KLG G +GEV + G R AIK +K +++ A L E V+K+L H +++L Sbjct: 11 KLGSGAYGEVLLCKDKLTGAER-AIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPNIMKL 69 Query: 329 YAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 Y ++ Y+V E G L D + K+ + V M Q+ SG Y+ + N VH Sbjct: 70 YEFFEDKRNYYLVMEVYRGGELFDEIILRQ-KFSEVDAAVIMK-QVLSGTTYLHKHNIVH 127 Query: 388 RDLRAANILV---GENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRFT 443 RDL+ N+L+ + + K+ DFGL+ E + R G + I APE L ++ Sbjct: 128 RDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYI---APE-VLRKKYD 183 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE 489 K DVWS G++L L G P+ G ++E+L +VE+G PP+ Sbjct: 184 EKCDVWSCGVILYILLC-GYPPFGGQTDQEILKRVEKGKFSFDPPD 228 >3MDY-A nrPDB Length = 337 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 78/288 (27%), Positives = 132/288 (45%), Gaps = 50/288 (17%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKK--LRHEKL 325 + +++ ++G+G +GEVWMG W G +VA+K T ++ +E ++ + +RHE + Sbjct: 37 KQIQMVKQIGKGRYGEVWMGKWRGE-KVAVKVF--FTTEEASWFRETEIYQTVLMRHENI 93 Query: 326 VQLYAVV-----SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 + A S +Y++T+Y GSL D+LK T L ++ +A SG+ ++ Sbjct: 94 LGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTT---LDAKSMLKLAYSSVSGLCHL 150 Query: 381 ERMNY--------VHRDLRAANILVGENLVCKVADFGLA-RLIED-NEYTARQGAKFPIK 430 + HRDL++ NILV +N C +AD GLA + I D NE + K Sbjct: 151 HTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTK 210 Query: 431 WTAPEAAL-------YGRFTIKSDVWSFGILLTELTTKG---------RVPYPGMV---- 470 P L + + I +D++SFG++L E+ + ++PY +V Sbjct: 211 RYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDP 270 Query: 471 ----NREVLDQVERGYRMP---CPPECPESLHDLMCQCWRKEPEERPT 511 RE++ + P EC + LM +CW P R T Sbjct: 271 SYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLT 318 >4YNZ-A nrPDB Length = 342 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 78/266 (29%), Positives = 132/266 (49%), Gaps = 34/266 (12%) Query: 271 RLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSPEAFLQ---EAQVMKKLRHEKLV 326 RLE LG+G G V +G T +VAIK + +S ++ E ++K + H ++ Sbjct: 13 RLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVL 72 Query: 327 QLYAVVSEEP-IYIVTEYMSKGSLLDFL--KG-----ETGKYLRLPQLVDMAAQIASGMA 378 +L+ V + +Y+V E++S G L D+L KG E K+ R QI S + Sbjct: 73 KLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFR---------QIISALD 123 Query: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAA 437 + + HRDL+ N+L+ E ++ADFG+A L + D+ G+ + PE Sbjct: 124 FCHSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSP---HYACPEVI 180 Query: 438 LYGRFT-IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMP--CPPECPES 493 ++ K+DVWS G++L L G +P+ R++L++V+RG + MP PP+C Sbjct: 181 RGEKYDGRKADVWSCGVILFALLV-GALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSL 239 Query: 494 LHDLMCQCWRKEPEERPTFEYLQAFL 519 L ++ + R T E++Q + Sbjct: 240 LRGMI----EVDAARRLTLEHIQKHI 261 >3DXN-A nrPDB Length = 287 Score = 90.5 bits (223), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 73/226 (32%), Positives = 114/226 (50%), Gaps = 19/226 (8%) Query: 275 KLGQGCFGEVWM--GTWNGTTRVAIKTLKPGTMSPE----AFLQEAQVMKKLRHEKLVQL 328 KLG G +GEV + G R AIK +K +++ A L E V+K+L H +++L Sbjct: 28 KLGSGAYGEVLLCKDKLTGAER-AIKIIKKSSVTTTSNSGALLDEVAVLKQLDHPNIMKL 86 Query: 329 YAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 Y ++ Y+V E G L D + K+ + V M Q+ SG Y+ + N VH Sbjct: 87 YEFFEDKRNYYLVMEVYRGGELFDEIILRQ-KFSEVDAAVIMK-QVLSGTTYLHKHNIVH 144 Query: 388 RDLRAANILV---GENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRFT 443 RDL+ N+L+ + + K+ DFGL+ E + R G + + APE L ++ Sbjct: 145 RDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAY---YIAPE-VLRKKYD 200 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE 489 K DVWS G++L L G P+ G ++E+L +VE+G PP+ Sbjct: 201 EKCDVWSCGVILYILLC-GYPPFGGQTDQEILKRVEKGKFSFDPPD 245 >5WNL-A nrPDB Length = 342 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 81/284 (28%), Positives = 139/284 (48%), Gaps = 29/284 (10%) Query: 275 KLGQGCFGEVW-MGTWNGTTRVAIK---TLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYA 330 K+G G FG+V+ + + T +AIK +L L+EA+ M+ + ++ +Y Sbjct: 27 KVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVYG 86 Query: 331 VVSEEPIYIVTEYMSKGSLLDFLKGETGKY-LRLPQLVDMAAQIASGMAYVERMN--YVH 387 + +EP+ +V EYM GSL L E + LR + + A GM ++ M+ +H Sbjct: 87 IC-QEPVGLVMEYMETGSLEKLLASEPLPWDLRF----RIVHETAVGMNFLHCMSPPLLH 141 Query: 388 RDLRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAALYGR--FT 443 +L+ ANIL+ + K++DFGLA+ + + + G I + PE F Sbjct: 142 LNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRLFD 201 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVN-REVLDQVERGYRMPCPPEC------PESLHD 496 K DV+SF I++ + T+ + P+ N ++ +V +G+R PP C SL Sbjct: 202 TKHDVYSFAIVIWGVLTQKK-PFADEKNILHIMMKVVKGHRPELPPICRPRPRACASLIG 260 Query: 497 LMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ-----YQPGEN 535 LM +CW +P+ RPTF+ + + ED + + ++PGE Sbjct: 261 LMQRCWHADPQVRPTFQEITSETEDLCEKPDEEVKDLAHEPGEK 304 >5LPZ-A nrPDB Length = 332 Score = 89.4 bits (220), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 65/198 (32%), Positives = 102/198 (51%), Gaps = 12/198 (6%) Query: 276 LGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKLVQL--YAVV 332 +G G FG+V+ + VAIK L F+ E + + K++H LV L Y V Sbjct: 25 IGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYCKV 84 Query: 333 SEEPIYIVTEYMSKGSLLDFLKG--ETGKYLRLPQLVDMAAQIASGMAYVERM---NYVH 387 +E + +V E+M GSL D L + G L +A A G+A++ + +H Sbjct: 85 GDERL-LVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIH 143 Query: 388 RDLRAANILVGENLVCKVADFGLARLIE--DNEYTARQGAKFPIKWTAPEAALYGRFTIK 445 RD++++N+L+ ENL +V+DFG+ARL+ D + A P + PE R + K Sbjct: 144 RDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTP-GYVPPEYYQSFRCSTK 202 Query: 446 SDVWSFGILLTELTTKGR 463 DV+S+G++L EL T R Sbjct: 203 GDVYSYGVVLLELLTGKR 220 >3Q5I-A nrPDB Length = 504 Score = 89.0 bits (219), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 67/228 (29%), Positives = 110/228 (48%), Gaps = 29/228 (12%) Query: 275 KLGQGCFGEVWM-GTWNGTTRVAIKTLKPGTMSP--------------EAFLQEAQVMKK 319 KLG G +GEV + NG + AIK +K E E ++K Sbjct: 43 KLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEISLLKS 102 Query: 320 LRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378 L H +++L+ V ++ Y+VTE+ G L + + ++ QI SG+ Sbjct: 103 LDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHK--FDECDAANIMKQILSGIC 160 Query: 379 YVERMNYVHRDLRAANILVGEN----LVCKVADFGLARLI-EDNEYTARQGAKFPIKWTA 433 Y+ + N VHRD++ NIL+ EN L K+ DFGL+ +D + R G + + A Sbjct: 161 YLHKHNIVHRDIKPENILL-ENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGTAY---YIA 216 Query: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481 PE L ++ K DVWS G+++ L G P+ G +++++ +VE+G Sbjct: 217 PE-VLKKKYNEKCDVWSCGVIMYILLC-GYPPFGGQNDQDIIKKVEKG 262 >5LPV-A nrPDB Length = 296 Score = 89.0 bits (219), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 65/198 (32%), Positives = 102/198 (51%), Gaps = 12/198 (6%) Query: 276 LGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKLVQL--YAVV 332 +G G FG+V+ + VAIK L F+ E + + K++H LV L Y V Sbjct: 25 IGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPLLGYCKV 84 Query: 333 SEEPIYIVTEYMSKGSLLDFLKG--ETGKYLRLPQLVDMAAQIASGMAYVERM---NYVH 387 +E + +V E+M GSL D L + G L +A A G+A++ + +H Sbjct: 85 GDERL-LVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIH 143 Query: 388 RDLRAANILVGENLVCKVADFGLARLIE--DNEYTARQGAKFPIKWTAPEAALYGRFTIK 445 RD++++N+L+ ENL +V+DFG+ARL+ D + A P + PE R + K Sbjct: 144 RDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTP-GYVPPEYYQSFRCSTK 202 Query: 446 SDVWSFGILLTELTTKGR 463 DV+S+G++L EL T R Sbjct: 203 GDVYSYGVVLLELLTGKR 220 >5TOS-A nrPDB Length = 395 Score = 88.6 bits (218), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 81/288 (28%), Positives = 132/288 (45%), Gaps = 43/288 (14%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGT--------MSPEAF----- 310 ++ + R + +G+G FG V+ G + +T + KPGT ++ E F Sbjct: 61 KLATRNFRPDSVIGEGGFGCVFKGWLDEST---LTPTKPGTGLVIAVKKLNQEGFQGHRE 117 Query: 311 -LQEAQVMKKLRHEKLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQL-- 366 L E + +L H LV+L + +E +V E+M KGSL + L + LP Sbjct: 118 WLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGAYFKPLPWFLR 177 Query: 367 VDMAAQIASGMAYVER--MNYVHRDLRAANILVGENLVCKVADFGLARL--IEDNEYTAR 422 V++A A G+A++ + ++RD++A+NIL+ + K++DFGLAR + D Y + Sbjct: 178 VNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGPMGDLSYVST 237 Query: 423 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRV-----------------P 465 + + APE G +SDV+SFG+LL E+ + R P Sbjct: 238 R-VMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEENLVDWARP 296 Query: 466 YPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFE 513 Y R+VL V+ PE + + QC EP+ RPT + Sbjct: 297 YL-TSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMD 343 >6CTH-A nrPDB Length = 309 Score = 88.2 bits (217), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 71/265 (26%), Positives = 123/265 (46%), Gaps = 29/265 (10%) Query: 273 EVKLGQGCFGEVWMGTW-NGTTRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKLVQLYA 330 E KLG+G FG V+ G + T +A+K + + + + E +++ +LRH+ LV+L Sbjct: 20 ENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISRLRHKNLVKLIG 79 Query: 331 VVSEE-PIYIVTEYMSKGSL-LDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN---Y 385 E + +V E+M+ GSL KG++ L + +AS + Y+ Sbjct: 80 WCHERGELMLVYEFMANGSLDSHIFKGKS--LLTWEVRYRIVKDLASALLYLHEEGDHCV 137 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445 +HRD++ +NI++ + K+ DFGLARL++ + + + + APE G+ + + Sbjct: 138 LHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSSGKASKE 197 Query: 446 SDVWSFGILLTELTTKGRVPYPGMV----------------NREVLDQVERGYRMPCPPE 489 SDV+SFG++ E+ + R P N +LD +R M P+ Sbjct: 198 SDVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVWESYGNERILDIADRKLGMAFDPK 257 Query: 490 CPESLHDLMCQCWRKEPEE--RPTF 512 E L +M W P RP+ Sbjct: 258 QLECL--VMVGLWCAHPSHNLRPSI 280 >3NCG-A nrPDB Length = 486 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 74/250 (29%), Positives = 121/250 (48%), Gaps = 23/250 (9%) Query: 276 LGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPE---AFLQEAQVMKKLRHEKLVQLYAV 331 LG+G FGEV T + A+K + + + L+E +++KKL H +++L+ + Sbjct: 30 LGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKLFEI 89 Query: 332 VSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQ--LVDMAAQIASGMAYVERMNYVHR 388 + + YIV E + G L D E K R + + Q+ SG+ Y+ + N VHR Sbjct: 90 LEDSSSFYIVGELYTGGELFD----EIIKRKRFSEHDAARIIKQVFSGITYMHKHNIVHR 145 Query: 389 DLRAANILV---GENLVCKVADFGLARLIEDN-EYTARQGAKFPIKWTAPEAALYGRFTI 444 DL+ NIL+ ++ K+ DFGL+ + N + R G + + APE L G + Sbjct: 146 DLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAY---YIAPE-VLRGTYDE 201 Query: 445 KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPCPPECPESLHDLMCQC 501 K DVWS G++L L + G P+ G ++L +VE G + +P + DL+ + Sbjct: 202 KCDVWSAGVILYILLS-GTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRKM 260 Query: 502 WRKEPEERPT 511 P R T Sbjct: 261 LTFHPSLRIT 270 >5JN2-A nrPDB Length = 525 Score = 87.4 bits (215), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 78/278 (28%), Positives = 134/278 (48%), Gaps = 38/278 (13%) Query: 276 LGQGCFGEVWM------GTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329 LG+G FGEV + G ++ + +K T E+ L+E Q++K+L H +++LY Sbjct: 75 LGKGSFGEVILCKDKITGQECAVKVISKRQVKQKT-DKESLLREVQLLKQLDHPNIMKLY 133 Query: 330 AVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA---QIASGMAYVERMNY 385 ++ Y+V E + G L D E R + VD A Q+ SG+ Y+ + Sbjct: 134 EFFEDKGYFYLVGEVYTGGELFD----EIISRKRFSE-VDAARIIRQVLSGITYMHKNKI 188 Query: 386 VHRDLRAANILV---GENLVCKVADFGLARLIEDNEYTARQGAKFPIK---WTAPEAALY 439 VHRDL+ N+L+ ++ ++ DFGL+ + A + K I + APE L+ Sbjct: 189 VHRDLKPENLLLESKSKDANIRIIDFGLS-----THFEASKKMKDKIGTAYYIAPE-VLH 242 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPCPPECPESLHD 496 G + K DVWS G++L L + G P+ G ++L +VE+G + +P + ES D Sbjct: 243 GTYDEKCDVWSTGVILYILLS-GCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKD 301 Query: 497 LMCQCWRKEPEERPT------FEYLQAFLEDYFTSTEP 528 L+ + P R + E++Q + ++ + P Sbjct: 302 LIRKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVP 339 >3OHT-A nrPDB Length = 389 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 64/235 (27%), Positives = 113/235 (48%), Gaps = 18/235 (7%) Query: 256 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMG-TWNGTTRVAIKTL-KP--GTMSPEAFL 311 Q L K WE+P L +G G +G V ++A+K L +P + + Sbjct: 40 QELNKTIWEVPERYQTLS-PVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSIIHAKRTY 98 Query: 312 QEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD--- 368 +E +++K ++HE ++ L V + P + E+ + + + ++ +L D Sbjct: 99 RELRLLKHMKHENVIGLLDVFT--PATSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 156 Query: 369 --MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK 426 + QI G+ Y+ + +HRDL+ +N+ V E+ K+ DFGLAR D+E T + Sbjct: 157 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT-DDEMTGYVATR 215 Query: 427 FPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480 + + APE L + + + D+WS G ++ EL T GR +PG + L Q+ R Sbjct: 216 W---YRAPEIMLNWMHYNMTVDIWSVGCIMAELLT-GRTLFPGTDHINQLQQIMR 266 >3COM-A nrPDB Length = 314 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 70/253 (27%), Positives = 115/253 (45%), Gaps = 14/253 (5%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324 P E + KLG+G +G V+ T + VAIK + P + ++E +M++ Sbjct: 27 PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQV-PVESDLQEIIKEISIMQQCDSPH 85 Query: 325 LVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 +V+ Y + ++IV EY GS+ D ++ K L ++ + G+ Y+ M Sbjct: 86 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLR-NKTLTEDEIATILQSTLKGLEYLHFM 144 Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443 +HRD++A NIL+ K+ADFG+A + D P W APE + Sbjct: 145 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPF-WMAPEVIQEIGYN 203 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP----PEC-PESLHDLM 498 +D+WS GI E+ +G+ PY + + + P P PE ++ D + Sbjct: 204 CVADIWSLGITAIEM-AEGKPPYADIHPMRAIFMIPTN---PPPTFRKPELWSDNFTDFV 259 Query: 499 CQCWRKEPEERPT 511 QC K PE+R T Sbjct: 260 KQCLVKSPEQRAT 272 >5USZ-A nrPDB Length = 289 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 75/280 (26%), Positives = 126/280 (45%), Gaps = 27/280 (9%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGT--------TRVAIKTL-KPGTMSPEAFLQEA 314 +I E L LGQG F +++ G T V +K L K E+F + A Sbjct: 4 KIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAA 63 Query: 315 QVMKKLRHEKLVQLYAV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373 +M KL H+ LV Y V V + +V E++ GSL +LK + + + +++A Q+ Sbjct: 64 SMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLK-KNKNCINILWKLEVAKQL 122 Query: 374 ASGMAYVERMNYVHRDLRAANILV--------GENLVCKVADFGLARLIEDNEYTARQGA 425 A+ M ++E +H ++ A NIL+ G K++D G++ + + + Sbjct: 123 AAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQER-- 180 Query: 426 KFPIKWTAPEAALYGR-FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484 I W PE + + +D WSFG L E+ + G P + ++ L E +++ Sbjct: 181 ---IPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQL 237 Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFT 524 P P L +L+ C EP+ RP+F + L FT Sbjct: 238 PAPKAA--ELANLINNCMDYEPDHRPSFRAIIRDLNSLFT 275 >3DFA-A nrPDB Length = 286 Score = 86.7 bits (213), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 74/250 (29%), Positives = 121/250 (48%), Gaps = 23/250 (9%) Query: 276 LGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPE---AFLQEAQVMKKLRHEKLVQLYAV 331 LG+G FGEV T + A+K + + + L+E +++KKL H +++L+ + Sbjct: 30 LGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHPNIMKLFEI 89 Query: 332 VSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQ--LVDMAAQIASGMAYVERMNYVHR 388 + + YIV E + G L D E K R + + Q+ SG+ Y+ + N VHR Sbjct: 90 LEDSSSFYIVGELYTGGELFD----EIIKRKRFSEHDAARIIKQVFSGITYMHKHNIVHR 145 Query: 389 DLRAANILV---GENLVCKVADFGLARLIEDN-EYTARQGAKFPIKWTAPEAALYGRFTI 444 DL+ NIL+ ++ K+ DFGL+ + N + R G + + APE L G + Sbjct: 146 DLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAY---YIAPE-VLRGTYDE 201 Query: 445 KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPCPPECPESLHDLMCQC 501 K DVWS G++L L + G P+ G ++L +VE G + +P + DL+ + Sbjct: 202 KCDVWSAGVILYILLS-GTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKDLIRKM 260 Query: 502 WRKEPEERPT 511 P R T Sbjct: 261 LTFHPSLRIT 270 >5F9E-A nrPDB Length = 353 Score = 86.7 bits (213), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 70/254 (27%), Positives = 124/254 (48%), Gaps = 22/254 (8%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEAFLQEAQVMKKL-----R 321 E L LG+G FG+V++ + T + AIK LK + + ++ V K++ Sbjct: 19 EDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWE 78 Query: 322 HEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 H L ++ ++E ++ V EY++ G L+ + ++ L + AA+I G+ ++ Sbjct: 79 HPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHI--QSCHKFDLSRATFYAAEIILGLQFL 136 Query: 381 ERMNYVHRDLRAANILVGENLVCKVADFGLAR--LIEDNEYTARQGAKFPIKWTAPEAAL 438 V+RDL+ NIL+ ++ K+ADFG+ + ++ D + G + APE L Sbjct: 137 HSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTP---DYIAPEILL 193 Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP--PECPES-LH 495 ++ D WSFG+LL E+ G+ P+ G E+ + RM P P E Sbjct: 194 GQKYNHSVDWWSFGVLLYEMLI-GQSPFHGQDEEELFHSI----RMDNPFYPRWLEKEAK 248 Query: 496 DLMCQCWRKEPEER 509 DL+ + + +EPE+R Sbjct: 249 DLLVKLFVREPEKR 262 >5NGU-A nrPDB Length = 381 Score = 86.7 bits (213), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 61/215 (28%), Positives = 105/215 (48%), Gaps = 20/215 (9%) Query: 276 LGQGCFGEVWMGTWN-GTTRVAIKTLKPGTMSP--EAFLQEAQVMKKLRHEKLVQLYAVV 332 +G+G +G V N RVAIK + P + L+E +++ + RHE ++ + ++ Sbjct: 50 IGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDII 109 Query: 333 ------SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 + +YIV + M D K ++L + QI G+ Y+ N + Sbjct: 110 RAPTIEQMKDVYIVQDLMET----DLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVL 165 Query: 387 HRDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKW-TAPEAALYGR-FT 443 HRDL+ +N+L+ K+ DFGLAR+ + D+++T +W APE L + +T Sbjct: 166 HRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYT 225 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 D+WS G +L E+ + R +PG + LDQ+ Sbjct: 226 KSIDIWSVGCILAEMLS-NRPIFPG---KHYLDQL 256 >4EWQ-A nrPDB Length = 383 Score = 86.3 bits (212), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 68/243 (27%), Positives = 117/243 (48%), Gaps = 21/243 (8%) Query: 256 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTL-KP--GTMSPEAFL 311 Q L K WE+P L +G G +G V T RVA+K L +P + + Sbjct: 34 QELNKTIWEVPERYQNLS-PVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTY 92 Query: 312 QEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD--- 368 +E +++K ++HE ++ L V + P + E+ + + + ++ +L D Sbjct: 93 RELRLLKHMKHENVIGLLDVFT--PARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHV 150 Query: 369 --MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK 426 + QI G+ Y+ + +HRDL+ +N+ V E+ K+ DFGLAR +D E T + Sbjct: 151 QFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDD-EMTGYVATR 209 Query: 427 FPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP 485 + + APE L + + D+WS G ++ EL T GR +PG + +DQ++ R+ Sbjct: 210 W---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFPGT---DHIDQLKLILRLV 262 Query: 486 CPP 488 P Sbjct: 263 GTP 265 >3MA6-A nrPDB Length = 298 Score = 85.9 bits (211), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 74/251 (29%), Positives = 124/251 (49%), Gaps = 28/251 (11%) Query: 276 LGQGCFGEVWM------GTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329 LG+G FGEV + G ++ + +K T E+ L+E Q++K+L H +++LY Sbjct: 40 LGKGSFGEVILCKDKITGQECAVKVISKRQVKQKT-DKESLLREVQLLKQLDHPNIMKLY 98 Query: 330 AVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA---QIASGMAYVERMNY 385 ++ Y+V E + G L D E R + VD A Q+ SG+ Y+ + Sbjct: 99 EFFEDKGYFYLVGEVYTGGELFD----EIISRKRFSE-VDAARIIRQVLSGITYMHKNKI 153 Query: 386 VHRDLRAANILV---GENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGR 441 VHRDL+ N+L+ ++ ++ DFGL+ E + + G + + APE L+G Sbjct: 154 VHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAY---YIAPE-VLHGT 209 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPCPPECPESLHDLM 498 + K DVWS G++L L + G P+ G ++L +VE+G + +P + ES DL+ Sbjct: 210 YDEKCDVWSTGVILYILLS-GCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLI 268 Query: 499 CQCWRKEPEER 509 + P R Sbjct: 269 RKMLTYVPSMR 279 >4AU8-A nrPDB Length = 296 Score = 85.5 bits (210), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 65/222 (29%), Positives = 113/222 (50%), Gaps = 24/222 (10%) Query: 275 KLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYA 330 K+G+G +G V+ T VA+K ++ P + L+E ++K+L+H+ +V+L+ Sbjct: 13 KIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHKNIVRLHD 72 Query: 331 VV-SEEPIYIVTEYMSKG--SLLDFLKGETGKYLRLPQLV-DMAAQIASGMAYVERMNYV 386 V+ S++ + +V E+ + D G+ P++V Q+ G+ + N + Sbjct: 73 VLHSDKKLTLVFEFCDQDLKKYFDSCNGDLD-----PEIVKSFLFQLLKGLGFCHSRNVL 127 Query: 387 HRDLRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAALYGR--F 442 HRDL+ N+L+ N K+ADFGLAR I Y+ A+ W P L+G + Sbjct: 128 HRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYS----AEVVTLWYRPPDVLFGAKLY 183 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484 + D+WS G + EL GR +PG +V DQ++R +R+ Sbjct: 184 STSIDMWSAGCIFAELANAGRPLFPG---NDVDDQLKRIFRL 222 >4KRC-A nrPDB Length = 317 Score = 85.5 bits (210), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 66/215 (30%), Positives = 112/215 (52%), Gaps = 16/215 (7%) Query: 275 KLGQGCFGEVWMGTWNGTT--RVAIKTLKPGTM--SPEAFLQEAQVMKKLRHEKLVQLYA 330 KLG G + V+ G N TT VA+K +K + +P ++E +MK+L+HE +V+LY Sbjct: 12 KLGNGTYATVYKGL-NKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHENIVRLYD 70 Query: 331 VV-SEEPIYIVTEYMS---KGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 V+ +E + +V E+M K + G T + L L + Q+ G+A+ + Sbjct: 71 VIHTENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKIL 130 Query: 387 HRDLRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAALYGR-FT 443 HRDL+ N+L+ + K+ DFGLAR I N +++ + + AP+ + R ++ Sbjct: 131 HRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEV---VTLWYRAPDVLMGSRTYS 187 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 D+WS G +L E+ T G+ +PG + E L + Sbjct: 188 TSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLI 221 >2WQN-A nrPDB Length = 310 Score = 85.1 bits (209), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 71/278 (25%), Positives = 120/278 (43%), Gaps = 14/278 (5%) Query: 249 PTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWM------GTWNGTTRVAIKTLKP 302 P +PQ + L D + R+E K+G+G F EV+ G +V I L Sbjct: 14 PQFQPQ-KALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMD 72 Query: 303 GTMSPEAFLQEAQVMKKLRHEKLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYL 361 + ++E ++K+L H +++ YA + + + IV E G L +K + Sbjct: 73 AKARADC-IKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKR 131 Query: 362 RLPQ--LVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEY 419 +P+ + Q+ S + ++ +HRD++ AN+ + V K+ D GL R Sbjct: 132 LIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTT 191 Query: 420 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVL-DQV 478 A P + +PE + KSD+WS G LL E+ Y +N L ++ Sbjct: 192 AAHSLVGTPY-YMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKI 250 Query: 479 ERGYRMPCPPE-CPESLHDLMCQCWRKEPEERPTFEYL 515 E+ P P + E L L+ C +PE+RP Y+ Sbjct: 251 EQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYV 288 >5EFQ-A nrPDB Length = 347 Score = 85.1 bits (209), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 68/248 (27%), Positives = 116/248 (46%), Gaps = 45/248 (18%) Query: 276 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYAV 331 +G+G +G+V+ T VA+K ++ P ++E +++++L H+ ++ + + Sbjct: 19 IGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEI 78 Query: 332 VSEE-----------PIYIVTEYMS-------KGSLLDFLKGETGKYLRLPQLVDMAAQI 373 V+++ Y+V EYM + L+ F + ++R Q+ Sbjct: 79 VTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMR---------QL 129 Query: 374 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE---YTARQGAKFPIK 430 G+ Y + N++HRD++ +NIL+ K+ADFGLARL E YT K Sbjct: 130 MEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYT----NKVITL 185 Query: 431 WTAPEAALYG--RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREV--LDQVERGYRMPC 486 W P L G R+T DVWS G +L EL TK + N+E+ L+ + R PC Sbjct: 186 WYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPI---FQANQELAQLELISRICGSPC 242 Query: 487 PPECPESL 494 P P+ + Sbjct: 243 PAVWPDVI 250 >4NST-A nrPDB Length = 351 Score = 85.1 bits (209), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 66/237 (27%), Positives = 115/237 (48%), Gaps = 23/237 (9%) Query: 276 LGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYAV 331 +G+G +G+V+ T VA+K ++ P ++E +++++L H +V + + Sbjct: 21 IGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEI 80 Query: 332 VSEE-----------PIYIVTEYMSKGSLLDFLKGETG-KYLRLPQLVDMAAQIASGMAY 379 V+++ Y+V EYM L+ L E+G + + Q+ G+ Y Sbjct: 81 VTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLL--ESGLVHFSEDHIKSFMKQLMEGLEY 137 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 + N++HRD++ +NIL+ + K+ADFGLARL ++E + K W P L Sbjct: 138 CHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLY-NSEESRPYTNKVITLWYRPPELLL 196 Query: 440 G--RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESL 494 G R+T DVWS G +L EL TK + + + L+ + R PCP P+ + Sbjct: 197 GEERYTPAIDVWSCGCILGELFTKKPI-FQANLELAQLELISRLCGSPCPAVWPDVI 252 >6QAU-A nrPDB Length = 280 Score = 85.1 bits (209), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 62/206 (30%), Positives = 101/206 (49%), Gaps = 21/206 (10%) Query: 276 LGQGCFGEVWMGTWNGTT--RVAIKTLKPGTMSPEAFL--QEAQVMKKLRHEKLVQLYAV 331 +G G F V+ G T VAIK++ +S L +E +++K+L+HE +V LY V Sbjct: 19 VGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENIVALYDV 78 Query: 332 VSEEP--IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 E P +++V EY + G L D+L+ + L + QIA+ M + +HRD Sbjct: 79 -QELPNSVFLVMEYCNGGDLADYLQAKGT--LSEDTIRVFLHQIAAAMRILHSKGIIHRD 135 Query: 390 LRAANILVG---------ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 440 L+ NIL+ + K+ADFG AR + N A P+ + APE + Sbjct: 136 LKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGS-PM-YMAPEVIMSQ 193 Query: 441 RFTIKSDVWSFGILLTELTTKGRVPY 466 + K+D+WS G ++ + G+ P+ Sbjct: 194 HYDAKADLWSIGTVIYQCLV-GKPPF 218 >4B6L-A nrPDB Length = 281 Score = 85.1 bits (209), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 71/256 (27%), Positives = 114/256 (44%), Gaps = 15/256 (5%) Query: 276 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSP----EAFLQEAQVMKKLRHEKLVQL-Y 329 LG+G F + T T + A+K + ++ E L E ++ + L+H +V+ + Sbjct: 17 LGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSH 76 Query: 330 AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 + IYI E S+ SL K L P++ QI SG+ Y+ + +HRD Sbjct: 77 HFEDADNIYIFLELCSRKSLAHIWKAR--HTLLEPEVRYYLRQILSGLKYLHQRGILHRD 134 Query: 390 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 449 L+ N + EN+ KV DFGLA +E E + P + APE L ++DVW Sbjct: 135 LKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTP-NYVAPEVLLRQGHGPEADVW 193 Query: 450 SFGILLTELTTKGRVPYPGMVNREVLDQVER-GYRMPCPPECPESLHDLMCQCWRKEPEE 508 S G ++ L G P+ +E +++ Y +P P L+ R P + Sbjct: 194 SLGCVMYTLLC-GSPPFETADLKETYRCIKQVHYTLPASLSLPAR--QLLAAILRASPRD 250 Query: 509 RPTFEYLQAFLEDYFT 524 RP+ + Q D+FT Sbjct: 251 RPSID--QILRHDFFT 264 >4JXF-A nrPDB Length = 266 Score = 85.1 bits (209), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 73/268 (27%), Positives = 121/268 (45%), Gaps = 21/268 (7%) Query: 268 ESLRLEVKLGQGCFGEVWMG-TWNGTTRVAIKTLKPGTMSPEAFLQ----EAQVMKKLRH 322 E ++ LG+G F V+ + + VAIK + M +Q E ++ +L+H Sbjct: 7 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKH 66 Query: 323 EKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 +++LY + +Y+V E G + +LK + + QI +GM Y+ Sbjct: 67 PSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSE-NEARHFMHQIITGMLYLH 125 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLA---RLIEDNEYTARQGAKFPIKWTAPEAAL 438 +HRDL +N+L+ N+ K+ADFGLA ++ + YT P + +PE A Sbjct: 126 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTL---CGTP-NYISPEIAT 181 Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMPCPPECPESLHDL 497 ++SDVWS G + L GR P+ + L++V Y MP DL Sbjct: 182 RSAHGLESDVWSLGCMFYTLLI-GRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAK--DL 238 Query: 498 MCQCWRKEPEERPTFEYLQAFLEDYFTS 525 + Q R+ P +R + L + L+ F S Sbjct: 239 IHQLLRRNPADRLS---LSSVLDHPFMS 263 >2QKW-B nrPDB Length = 321 Score = 85.1 bits (209), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 58/188 (30%), Positives = 96/188 (51%), Gaps = 5/188 (2%) Query: 276 LGQGCFGEVWMGTWNGTTRVAIKTLKP-GTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE 334 +G G FG+V+ G +VA+K P + E F E + + RH LV L E Sbjct: 47 IGHGVFGKVYKGVLRDGAKVALKRRTPESSQGIEEFETEIETLSFCRHPHLVSLIGFCDE 106 Query: 335 -EPIYIVTEYMSKGSLLDFLKGETGKYLRLP--QLVDMAAQIASGMAYVERMNYVHRDLR 391 + ++ +YM G+L L G + + Q +++ A G+ Y+ +HRD++ Sbjct: 107 RNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTRAIIHRDVK 166 Query: 392 AANILVGENLVCKVADFGLARL-IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS 450 + NIL+ EN V K+ DFG+++ E ++ K + + PE + GR T KSDV+S Sbjct: 167 SINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRLTEKSDVYS 226 Query: 451 FGILLTEL 458 FG++L E+ Sbjct: 227 FGVVLFEV 234 >2X4F-A nrPDB Length = 373 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 67/211 (31%), Positives = 100/211 (47%), Gaps = 15/211 (7%) Query: 276 LGQGCFGEVWMGTWNGT-TRVAIKTLKP-GTMSPEAFLQEAQVMKKLRHEKLVQLY-AVV 332 LG G FG+V T ++A K +K G E E VM +L H L+QLY A Sbjct: 97 LGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDAFE 156 Query: 333 SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRA 392 S+ I +V EY+ G L D + E+ L ++ M QI G+ ++ +M +H DL+ Sbjct: 157 SKNDIVLVMEYVDGGELFDRIIDESYNLTELDTILFMK-QICEGIRHMHQMYILHLDLKP 215 Query: 393 ANILVGENLV--CKVADFGLARLIEDNEYTARQGAKFPI---KWTAPEAALYGRFTIKSD 447 NIL K+ DFGLAR Y R+ K ++ APE Y + +D Sbjct: 216 ENILCVNRDAKQIKIIDFGLAR-----RYKPREKLKVNFGTPEFLAPEVVNYDFVSFPTD 270 Query: 448 VWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 +WS G++ L + G P+ G + E L+ + Sbjct: 271 MWSVGVIAYMLLS-GLSPFLGDNDAETLNNI 300 >5YKS-A nrPDB Length = 377 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 68/258 (26%), Positives = 127/258 (49%), Gaps = 24/258 (9%) Query: 272 LEVKLGQGCFGEVWMGTWNGT-TRVAIKTL---KPGTMSPEAFLQEAQVMKKLRHEKLVQ 327 L+ LG+G F V + T +VA+K + K T++ QE + MK ++H +V+ Sbjct: 39 LDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLVQHPNIVR 98 Query: 328 LYAVV-SEEPIYIVTEYMSKGSLLDF-LKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 LY V+ ++ +Y++ E G + D+ +K E G L + AQI ++Y +++ Sbjct: 99 LYEVIDTQTKLYLILELGDGGDMFDYIMKHEEGLNEDLAK--KYFAQIVHAISYCHKLHV 156 Query: 386 VHRDLRAANILVGENL-VCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRFT 443 VHRDL+ N++ E + K+ DFG + + + T G+ + ++APE L + Sbjct: 157 VHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGS---LAYSAPEILLGDEYD 213 Query: 444 IKS-DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPC----PPECPESLHDLM 498 + D+WS G++L L G+ P+ + E L + M C P + DL+ Sbjct: 214 APAVDIWSLGVILFMLVC-GQPPFQEANDSETLTMI-----MDCKYTVPSHVSKECKDLI 267 Query: 499 CQCWRKEPEERPTFEYLQ 516 + +++P+ R + E ++ Sbjct: 268 TRMLQRDPKRRASLEEIE 285 >4AN9-A nrPDB Length = 301 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 75/263 (28%), Positives = 127/263 (48%), Gaps = 32/263 (12%) Query: 275 KLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSP---EAFLQEAQVMKKLRHEKLVQLY-A 330 +LG G G V+ + + V + L + P ++E QV+ + +V Y A Sbjct: 16 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 75 Query: 331 VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQ--LVDMAAQIASGMAYV-ERMNYVH 387 S+ I I E+M GSL LK K R+P+ L ++ + G+ Y+ E+ +H Sbjct: 76 FYSDGEISICMEHMDGGSLDQVLK----KAGRIPEQILGKVSIAVIKGLTYLREKHKIMH 131 Query: 388 RDLRAANILVGENLVCKVADFGLA-RLIED--NEYTARQGAKFPIKWTAPEAALYGRFTI 444 RD++ +NILV K+ DFG++ +LI++ NE+ + + +PE +++ Sbjct: 132 RDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTR------SYMSPERLQGTHYSV 185 Query: 445 KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESL-----HDLMC 499 +SD+WS G+ L E+ GR P P M E+LD + PP+ P ++ D + Sbjct: 186 QSDIWSMGLSLVEMAV-GRYPRPPMAIFELLDYIVN----EPPPKLPSAVFSLEFQDFVN 240 Query: 500 QCWRKEPEERPTFEYL--QAFLE 520 +C K P ER + L AF++ Sbjct: 241 KCLIKNPAERADLKQLMVHAFIK 263 >4D2V-A nrPDB Length = 356 Score = 84.3 bits (207), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 78/267 (29%), Positives = 124/267 (46%), Gaps = 14/267 (5%) Query: 272 LEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEA--FLQEAQVMKKLRHEKLVQL 328 L +G G F +V + T VAIK + T+ + E + +K LRH+ + QL Sbjct: 33 LHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQL 92 Query: 329 YAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 Y V+ + I++V EY G L D++ + L + + QI S +AYV Y H Sbjct: 93 YHVLETANKIFMVLEYCPGGELFDYIISQDR--LSEEETRVVFRQIVSAVAYVHSQGYAH 150 Query: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS- 446 RDL+ N+L E K+ DFGL + N+ Q + + APE + G+ + S Sbjct: 151 RDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPE-LIQGKSYLGSE 209 Query: 447 -DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKE 505 DVWS GILL L G +P+ ++ ++ RG + P S L+ Q + + Sbjct: 210 ADVWSMGILLYVLMC-GFLPFDDDTAAALVAKIMRG-KYDVPKWLSPSSILLLQQMLQVD 267 Query: 506 PEERPTFEYLQA---FLEDYFTSTEPQ 529 P++R + + L ++DY E Q Sbjct: 268 PKKRISMKNLLNHPWIMQDYNYPVEWQ 294 >4M66-A nrPDB Length = 325 Score = 84.0 bits (206), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 80/278 (28%), Positives = 127/278 (45%), Gaps = 41/278 (14%) Query: 265 IPRESLRLEVKLGQGCFGEVWMG---TWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR 321 + RE L+ +G+G FG V+ TWN VA+K + +S E + M LR Sbjct: 17 VSREELKKLEFVGKGGFGVVFRAHHRTWNHD--VAVKIVNSKKIS-----WEVKAMVNLR 69 Query: 322 HEKLVQLYAVVSE------EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIAS 375 +E ++ L V + +VT +M GSL L+ E + P L + ++ Sbjct: 70 NENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPR--PWPLLCRLLQEVVL 127 Query: 376 GMAYVERMN--YVHRDLRAANILVGENLVCKVADFGLARL-----IEDNEYTARQGAKFP 428 GM Y+ ++ +HRDL+ +NIL+ L K+ADFGL+ + + + Sbjct: 128 GMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGT 187 Query: 429 IKWTAPEAALYGRFTIK----SDVWSFGILLTELTTKGR----VPYPGMVNREVLDQVER 480 + + PE L + +K SDV+SFGIL+ + GR V ++ V D+ R Sbjct: 188 LAYLDPE--LLFKVNLKASKASDVYSFGILVWAVLA-GREAELVDKTSLIRETVCDRQSR 244 Query: 481 GYRMPCPPECPES-----LHDLMCQCWRKEPEERPTFE 513 PP PE+ L +LM CW + E RP+F+ Sbjct: 245 PPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQ 282 >3REP-A nrPDB Length = 271 Score = 84.0 bits (206), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 67/266 (25%), Positives = 118/266 (44%), Gaps = 22/266 (8%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKP---GTMSPEAFLQEAQVMKKLRHEK 324 + L KL + GE+W G W G + +K LK T F +E ++ H Sbjct: 10 KQLNFLTKLNENHSGELWKGRWQGND-IVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPN 68 Query: 325 LVQLYAVVSEEPI---YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 ++ + P ++T +M GSL + L T + Q V A +A GMA++ Sbjct: 69 VLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLH 128 Query: 382 RMNYV--HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ-GAKFPIKWTAPEAAL 438 + + L + ++++ E++ +++ + D +++ + G + W APEA Sbjct: 129 TLEPLIPRHALNSRSVMIDEDMTARIS-------MADVKFSFQSPGRMYAPAWVAPEALQ 181 Query: 439 YGRFTIK---SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPPECPESL 494 +D+WSF +LL EL T+ VP+ + N E+ +V G R PP + Sbjct: 182 KKPEDTNRRSADMWSFAVLLWELVTR-EVPFADLSNMEIGMKVALEGLRPTIPPGISPHV 240 Query: 495 HDLMCQCWRKEPEERPTFEYLQAFLE 520 LM C ++P +RP F+ + LE Sbjct: 241 SKLMKICMNEDPAKRPKFDMIVPILE 266 >4WNO-A nrPDB Length = 287 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 61/218 (27%), Positives = 102/218 (46%), Gaps = 24/218 (11%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGT--TRVAIKTLKPGTMSPEAFL--QEAQVMK 318 +E R+ L +G G F V+ G VA+K + ++ L +E +++K Sbjct: 18 FEFSRKDL-----IGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILK 72 Query: 319 KLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 +L+HE +V LY +Y+V EY + G L D+L + L + QIA M Sbjct: 73 ELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAM--RTLSEDTIRLFLQQIAGAM 130 Query: 378 AYVERMNYVHRDLRAANILVG---------ENLVCKVADFGLARLIEDNEYTARQGAKFP 428 + +HRDL+ NIL+ ++ K+ADFG AR ++ N A P Sbjct: 131 RLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGS-P 189 Query: 429 IKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPY 466 + + APE + + K+D+WS G ++ + T G+ P+ Sbjct: 190 M-YMAPEVIMSQHYDGKADLWSIGTIVYQCLT-GKAPF 225 >1U5R-A nrPDB Length = 348 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 74/255 (29%), Positives = 118/255 (46%), Gaps = 26/255 (10%) Query: 275 KLGQGCFGEVWMG-TWNGTTRVAIKTLK-PGTMSPEAF---LQEAQVMKKLRHEKLVQLY 329 ++G G FG V+ + VAIK + G S E + ++E + ++KLRH +Q Sbjct: 61 EIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYR 120 Query: 330 AV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 + E ++V EY GS D L+ K L+ ++ + G+AY+ N +HR Sbjct: 121 GCYLREHTAWLVMEY-CLGSASDLLEVHK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHR 178 Query: 389 DLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALY---GRFTI 444 D++A NIL+ E + K+ DFG A ++ N + G + W APE L G++ Sbjct: 179 DVKAGNILLSEPGLVKLGDFGSASIMAPANSFV---GTPY---WMAPEVILAMDEGQYDG 232 Query: 445 KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP----ECPESLHDLMCQ 500 K DVWS GI EL + P + N + + + P E + + Sbjct: 233 KVDVWSLGITCIELAERK----PPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDS 288 Query: 501 CWRKEPEERPTFEYL 515 C +K P++RPT E L Sbjct: 289 CLQKIPQDRPTSEVL 303 >5D7A-A nrPDB Length = 308 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 68/266 (25%), Positives = 115/266 (43%), Gaps = 25/266 (9%) Query: 276 LGQGCFGEVWMGTWNGTTRVA-IKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY--AVV 332 +G G +G+V+ G T ++A IK + E QE ++KK H + + Y A + Sbjct: 25 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFI 84 Query: 333 SEEP------IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 + P +++V E+ GS+ D +K G L+ + + +I G++++ + + Sbjct: 85 KKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVI 144 Query: 387 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR----- 441 HRD++ N+L+ EN K+ DFG++ + D R W APE Sbjct: 145 HRDIKGQNVLLTENAEVKLVDFGVSAQL-DRTVGRRNTFIGTPYWMAPEVIACDENPDAT 203 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP----PECPESLHDL 497 + KSD+WS GI E+ +G P M L + R P P + + Sbjct: 204 YDFKSDLWSLGITAIEM-AEGAPPLCDMHPMRALFLIPRN---PAPRLKSKKWSKKFQSF 259 Query: 498 MCQCWRKEPEERPTFEYL--QAFLED 521 + C K +RP E L F+ D Sbjct: 260 IESCLVKNHSQRPATEQLMKHPFIRD 285 >5C01-A nrPDB Length = 342 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 71/233 (30%), Positives = 107/233 (45%), Gaps = 19/233 (8%) Query: 294 RVAIKTLKPGTMSPE-AFLQEAQVMKKLRHEKLVQLYAVVSEEPIYI-VTEYMSKGSLLD 351 RV +K L P AF + A +M ++ H L ++ V P I VTEY+ G L Sbjct: 109 RVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDV 168 Query: 352 FLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILV-------GENLVCK 404 +L+ E G ++V +A Q+AS ++Y+E N VH ++ NIL+ G + K Sbjct: 169 WLRRERGHVPMAWKMV-VAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIK 227 Query: 405 VADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS--DVWSFGILLTELTTKG 462 ++D G+ E + I W APE G ++ + D W FG L E+ G Sbjct: 228 LSDPGVGLGALSREERVER-----IPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDG 282 Query: 463 RVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYL 515 P E +R +R+P P CP+ L L QC EP +RP+F + Sbjct: 283 EAPLQSRSPSEKEHFYQRQHRLP-EPSCPQ-LATLTSQCLTYEPTQRPSFRTI 333 >2BPM-A nrPDB Length = 309 Score = 83.2 bits (204), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 64/223 (28%), Positives = 113/223 (50%), Gaps = 16/223 (7%) Query: 275 KLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYA 330 K+G+G +G V+ T V A+K ++ T + P ++E ++K+L H +V+L Sbjct: 14 KIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 73 Query: 331 VV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 V+ +E +Y+V E++ + L F+ + LP + Q+ G+A+ +HRD Sbjct: 74 VIHTENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRD 132 Query: 390 LRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAALYGR-FTIKS 446 L+ N+L+ K+ADFGLAR + YT + + APE L + ++ Sbjct: 133 LKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVT---LWYRAPEILLGCKYYSTAV 189 Query: 447 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE 489 D+WS G + E+ T+ R +PG + E+ DQ+ R +R P+ Sbjct: 190 DIWSLGCIFAEMVTR-RALFPG--DSEI-DQLFRIFRTLGTPD 228 >4WOV-A nrPDB Length = 317 Score = 83.2 bits (204), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 71/233 (30%), Positives = 107/233 (45%), Gaps = 19/233 (8%) Query: 294 RVAIKTLKPGTMSPE-AFLQEAQVMKKLRHEKLVQLYAVVSEEPIYI-VTEYMSKGSLLD 351 RV +K L P AF + A +M ++ H L ++ V P I VTEY+ G L Sbjct: 86 RVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDV 145 Query: 352 FLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILV-------GENLVCK 404 +L+ E G ++V +A Q+AS ++Y+E N VH ++ NIL+ G + K Sbjct: 146 WLRRERGHVPMAWKMV-VAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIK 204 Query: 405 VADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS--DVWSFGILLTELTTKG 462 ++D G+ E + I W APE G ++ + D W FG L E+ G Sbjct: 205 LSDPGVGLGALSREERVER-----IPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDG 259 Query: 463 RVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYL 515 P E +R +R+P P CP+ L L QC EP +RP+F + Sbjct: 260 EAPLQSRSPSEKEHFYQRQHRLP-EPSCPQ-LATLTSQCLTYEPTQRPSFRTI 310 >4QTB-A nrPDB Length = 380 Score = 83.2 bits (204), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 61/215 (28%), Positives = 105/215 (48%), Gaps = 20/215 (9%) Query: 276 LGQGCFGEVWMGTWN-GTTRVAIKTLKPGTMSP--EAFLQEAQVMKKLRHEKLVQLYAVV 332 +G+G +G V + TRVAIK + P + L+E Q++ + RHE ++ + ++ Sbjct: 49 IGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDIL 108 Query: 333 ------SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 + +YIV + M D K + L + QI G+ Y+ N + Sbjct: 109 RASTLEAMRDVYIVQDLMET----DLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVL 164 Query: 387 HRDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKW-TAPEAALYGR-FT 443 HRDL+ +N+L+ K+ DFGLAR+ + ++++T +W APE L + +T Sbjct: 165 HRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYT 224 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 D+WS G +L E+ + R +PG + LDQ+ Sbjct: 225 KSIDIWSVGCILAEMLS-NRPIFPG---KHYLDQL 255 >2JAM-A nrPDB Length = 304 Score = 83.2 bits (204), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 72/258 (27%), Positives = 123/258 (47%), Gaps = 16/258 (6%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEAFLQ-EAQVMKKLRH 322 I + + +EV LG G F EV++ T ++ A+K +K ++ L+ E V+KK++H Sbjct: 7 IRKTFIFMEV-LGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKH 65 Query: 323 EKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 E +V L + S Y+V + +S G L D + E G Y + + Q+ S + Y+ Sbjct: 66 ENIVTLEDIYESTTHYYLVMQLVSGGELFDRIL-ERGVYTEKDASL-VIQQVLSAVKYLH 123 Query: 382 RMNYVHRDLRAANILV---GENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438 VHRDL+ N+L EN + DFGL+++ ++ + G + APE Sbjct: 124 ENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTP---GYVAPEVLA 180 Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY---RMPCPPECPESLH 495 ++ D WS G+ +T + G P+ ++ ++++ GY P + ES Sbjct: 181 QKPYSKAVDCWSIGV-ITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAK 239 Query: 496 DLMCQCWRKEPEERPTFE 513 D +C K+P ER T E Sbjct: 240 DFICHLLEKDPNERYTCE 257 >2Y4I-B nrPDB Length = 319 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 78/305 (25%), Positives = 127/305 (41%), Gaps = 26/305 (8%) Query: 249 PTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL---KPGTM 305 P QT ++ W+IP E L + +G+G FG+V+ G W+G VAI+ + + Sbjct: 15 PRKASQTSIFLQE-WDIPFEQLEIGELIGKGRFGQVYHGRWHG--EVAIRLIDIERDNED 71 Query: 306 SPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQ 365 +AF +E ++ RHE +V P + + KG L + + L + + Sbjct: 72 QLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNK 131 Query: 366 LVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGA 425 +A +I GM Y+ +H+DL++ N+ V + DFGL I R+ Sbjct: 132 TRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVV-ITDFGLFS-ISGVLQAGRRED 189 Query: 426 KFPIK--WTAPEAALYGR------------FTIKSDVWSFGILLTELTTKGRVPYPGMVN 471 K I+ W A R F+ SDV++ G + EL + P+ Sbjct: 190 KLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAR-EWPFKTQPA 248 Query: 472 REVLDQVERGYRMPCPPECP--ESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 ++ Q+ G + P + + + D++ CW E EERPTF L LE Sbjct: 249 EAIIWQMGTGMK-PNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRL 307 Query: 530 YQPGE 534 PG Sbjct: 308 SHPGH 312 >2GCD-A nrPDB Length = 309 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 74/255 (29%), Positives = 118/255 (46%), Gaps = 26/255 (10%) Query: 275 KLGQGCFGEVWMG-TWNGTTRVAIKTLK-PGTMSPEAF---LQEAQVMKKLRHEKLVQLY 329 ++G G FG V+ + VAIK + G S E + ++E + ++KLRH +Q Sbjct: 22 EIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKLRHPNTIQYR 81 Query: 330 AV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 + E ++V EY GS D L+ K L+ ++ + G+AY+ N +HR Sbjct: 82 GCYLREHTAWLVMEY-CLGSASDLLEVHK-KPLQEVEIAAVTHGALQGLAYLHSHNMIHR 139 Query: 389 DLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALY---GRFTI 444 D++A NIL+ E + K+ DFG A ++ N + G + W APE L G++ Sbjct: 140 DVKAGNILLSEPGLVKLGDFGSASIMAPANSFV---GTPY---WMAPEVILAMDEGQYDG 193 Query: 445 KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP----ECPESLHDLMCQ 500 K DVWS GI EL + P + N + + + P E + + Sbjct: 194 KVDVWSLGITCIELAERK----PPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDS 249 Query: 501 CWRKEPEERPTFEYL 515 C +K P++RPT E L Sbjct: 250 CLQKIPQDRPTSEVL 264 >6FDY-U nrPDB Length = 276 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 73/266 (27%), Positives = 124/266 (46%), Gaps = 24/266 (9%) Query: 263 WEIPR-ESLRLEVKLGQGCFGEVWMGTWNGTTR--VAIKTLKPGTM---SPEAFLQEAQV 316 W PR + L +LG G + V+ TR VAIK + ++ S E L E ++ Sbjct: 5 WGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEI 64 Query: 317 MKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD--MAAQI 373 +K +RH +VQL + IY++ E+ + G L F+ LP+ V Q+ Sbjct: 65 LKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRRI----LPEKVARVFMQQL 120 Query: 374 ASGMAYVERMNYVHRDLRAANILVG--ENLVCKVADFGLARLIE--DNEYTARQGAKFPI 429 AS + ++ N H DL+ NIL+ E K+ADFG A+ + D ++ R P+ Sbjct: 121 ASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGS---PL 177 Query: 430 KWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE--RGYRMPCP 487 + APE ++ + D+WS G++L E G+ P+ E+ +++ R +P Sbjct: 178 -YMAPEMVCQRQYDARVDLWSMGVILYE-ALFGQPPFASRSFSELEEKIRSNRVIELPLR 235 Query: 488 PECPESLHDLMCQCWRKEPEERPTFE 513 P DL+ + ++P R +F+ Sbjct: 236 PLLSRDCRDLLQRLLERDPSRRISFQ 261 >3UIM-A nrPDB Length = 326 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 65/197 (32%), Positives = 102/197 (51%), Gaps = 10/197 (5%) Query: 276 LGQGCFGEVWMGTWNGTTRVAIKTLKPG-TMSPE-AFLQEAQVMKKLRHEKLVQL--YAV 331 LG+G FG+V+ G T VA+K LK T E F E +++ H L++L + + Sbjct: 38 LGRGGFGKVYKGRLADGTLVAVKRLKEERTQGGELQFQTEVEMISMAVHRNLLRLRGFCM 97 Query: 332 VSEEPIYIVTEYMSKGSLLDFLKG--ETGKYLRLPQLVDMAAQIASGMAYVERM---NYV 386 E + +V YM+ GS+ L+ E+ L P+ +A A G+AY+ + Sbjct: 98 TPTERL-LVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLHDHCDPKII 156 Query: 387 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 446 HRD++AANIL+ E V DFGLA+L++ + + I APE G+ + K+ Sbjct: 157 HRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKT 216 Query: 447 DVWSFGILLTELTTKGR 463 DV+ +G++L EL T R Sbjct: 217 DVFGYGVMLLELITGQR 233 >5G6V-A nrPDB Length = 324 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 67/229 (29%), Positives = 107/229 (46%), Gaps = 23/229 (10%) Query: 275 KLGQGCFGEVWMGTWNGTTR-VAIKT--LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAV 331 KLG+G + V+ G T VA+K L+ +P ++E ++K L+H +V L+ + Sbjct: 9 KLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDI 68 Query: 332 V-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDL 390 + +E+ + +V EY+ K L +L + G + + + Q+ G+AY R +HRDL Sbjct: 69 IHTEKSLTLVFEYLDK-DLKQYL-DDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDL 126 Query: 391 RAANILVGENLVCKVADFGLARL------IEDNEYTARQGAKFPIKWTAPEAALYGR--F 442 + N+L+ E K+ADFGLAR DNE W P L G + Sbjct: 127 KPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTL--------WYRPPDILLGSTDY 178 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP 491 + + D+W G + E+ T GR +PG E L + R P P Sbjct: 179 STQIDMWGVGCIFYEMAT-GRPLFPGSTVEEQLHFIFRILGTPTEETWP 226 >3T04-A nrPDB Length = 123 Score = 82.0 bits (201), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 47/127 (37%), Positives = 74/127 (58%), Gaps = 8/127 (6%) Query: 136 PSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFD 195 PSNY+ P +S++ WY G ++R +E LL + N G+FLVRESE++ G +S+ Sbjct: 3 PSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISL---- 56 Query: 196 NAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQ 254 +G V HY+I G Y++S ++FN+L +LV ++S ADGL L P +KP Sbjct: 57 RYEG-RVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPT 115 Query: 255 TQGLAKD 261 G++ + Sbjct: 116 VYGVSPN 122 >4CQG-A nrPDB Length = 331 Score = 81.6 bits (200), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 68/217 (31%), Positives = 104/217 (47%), Gaps = 11/217 (5%) Query: 276 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEA--FLQEAQVMKKLRHEKLVQLYAVV 332 +G G F +V + T VAIK + + + E +K LRH+ + QLY V+ Sbjct: 17 IGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQHICQLYHVL 76 Query: 333 -SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLR 391 ++ I++V EY G L D++ + L + + QI S +AYV Y HRDL+ Sbjct: 77 ETKNKIFMVLEYCPGGELFDYIISQDR--LSEEETRVVFRQILSAVAYVHSQGYAHRDLK 134 Query: 392 AANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS--DVW 449 N+L EN K+ DFGL + N+ Q + + APE + G+ + S DVW Sbjct: 135 PENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPE-LIQGKSYLGSEADVW 193 Query: 450 SFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMP 485 S GILL L G +P+ + ++ RG Y +P Sbjct: 194 SMGILLYVLMC-GFLPFDDDNVMALYKKIMRGKYEVP 229 >4RA4-A nrPDB Length = 355 Score = 81.6 bits (200), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 61/210 (29%), Positives = 109/210 (51%), Gaps = 11/210 (5%) Query: 276 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGTM----SPEAFLQEAQVMKKL-RHEKLVQLY 329 LG+G FG+V + GT + AIK LK + E + E +V+ L + L QL+ Sbjct: 28 LGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLH 87 Query: 330 AVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 + + + +Y V EY++ G L+ ++ + GK+ + PQ V AA+I+ G+ ++ + ++R Sbjct: 88 SCFQTVDRLYFVMEYVNGGDLMYHIQ-QVGKF-KEPQAVFYAAEISIGLFFLHKRGIIYR 145 Query: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 448 DL+ N+++ K+ADFG+ + + T R P + APE Y + D Sbjct: 146 DLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTP-DYIAPEIIAYQPYGKSVDW 204 Query: 449 WSFGILLTELTTKGRVPYPGMVNREVLDQV 478 W++G+LL E+ G+ P+ G E+ + Sbjct: 205 WAYGVLLYEMLA-GQPPFDGEDEDELFQSI 233 >3NIZ-A nrPDB Length = 311 Score = 81.3 bits (199), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 62/225 (27%), Positives = 112/225 (49%), Gaps = 13/225 (5%) Query: 275 KLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYAV 331 K+G+G +G V+ + VA+K ++ P ++E ++K+L H +V L V Sbjct: 28 KVGEGTYGVVYKAKDSQGRIVALKRIRLDAEDEGIPSTAIREISLLKELHHPNIVSLIDV 87 Query: 332 V-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDL 390 + SE + +V E+M K + +TG L+ Q+ Q+ G+A+ + +HRDL Sbjct: 88 IHSERCLTLVFEFMEKDLKKVLDENKTG--LQDSQIKIYLYQLLRGVAHCHQHRILHRDL 145 Query: 391 RAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSD 447 + N+L+ + K+ADFGLAR I YT + + AP+ + +++ D Sbjct: 146 KPQNLLINSDGALKLADFGLARAFGIPVRSYTHEV---VTLWYRAPDVLMGSKKYSTSVD 202 Query: 448 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE 492 +WS G + E+ T G+ +PG+ + + L ++ P P E P+ Sbjct: 203 IWSIGCIFAEMIT-GKPLFPGVTDDDQLPKIFSILGTPNPREWPQ 246 >6GU6-A nrPDB Length = 302 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 75/268 (27%), Positives = 125/268 (46%), Gaps = 38/268 (14%) Query: 275 KLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYA 330 K+G+G +G V+ G T +V A+K ++ + P ++E ++K+LRH +V L Sbjct: 14 KIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQD 73 Query: 331 VVSEEP-IYIVTEYMSKGSLLDFLKG-ETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 V+ ++ +Y++ E++S L +L G+Y+ + QI G+ + +HR Sbjct: 74 VLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHR 132 Query: 389 DLRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAAL-YGRFTIK 445 DL+ N+L+ + K+ADFGLAR I YT + + +PE L R++ Sbjct: 133 DLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEV---VTLWYRSPEVLLGSARYSTP 189 Query: 446 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKE 505 D+WS G + EL TK P +DQ+ R +R P + W Sbjct: 190 VDIWSIGTIFAELATKK----PLFHGDSEIDQLFRIFRALGTPN---------NEVW--- 233 Query: 506 PEERPTFEYLQAFLEDYFTSTEPQYQPG 533 P E LQ DY +T P+++PG Sbjct: 234 ----PEVESLQ----DY-KNTFPKWKPG 252 >4LG4-A nrPDB Length = 299 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 64/252 (25%), Positives = 110/252 (43%), Gaps = 12/252 (4%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKL 325 P E + KLG+G +G V+ + +V P + ++E +M++ + Sbjct: 9 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYV 68 Query: 326 VQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN 384 V+ Y + ++IV EY GS+ D ++ K L ++ + G+ Y+ M Sbjct: 69 VKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLR-NKTLIEDEIATILKSTLKGLEYLHFMR 127 Query: 385 YVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI 444 +HR+++A NIL+ K+ADFG+A + D P W APE + Sbjct: 128 KIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPF-WMAPEVIQEIGYNC 186 Query: 445 KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP----PEC-PESLHDLMC 499 +D+WS GI E+ +G+ PY + + + P P PE + D + Sbjct: 187 VADIWSLGITSIEM-AEGKPPYADIHPMRAIFMIPTN---PPPTFRKPELWSDDFTDFVK 242 Query: 500 QCWRKEPEERPT 511 +C K PE+R T Sbjct: 243 KCLVKNPEQRAT 254 >1CM8-A nrPDB Length = 367 Score = 80.9 bits (198), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 69/244 (28%), Positives = 123/244 (50%), Gaps = 23/244 (9%) Query: 256 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT--RVAIKTL-KP--GTMSPEAF 310 Q + K AWE+ R R +G G +G V +G T +VAIK L +P + + Sbjct: 14 QEVTKTAWEV-RAVYRDLQPVGSGAYGAVCSAV-DGRTGAKVAIKKLYRPFQSELFAKRA 71 Query: 311 LQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD-- 368 +E +++K +RHE ++ L V + P + ++ ++ F+ + GK ++ +L + Sbjct: 72 YRELRLLKHMRHENVIGLLDVFT--PDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDR 129 Query: 369 ---MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGA 425 + Q+ G+ Y+ +HRDL+ N+ V E+ K+ DFGLAR D+E T Sbjct: 130 IQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQ-ADSEMTGYVVT 188 Query: 426 KFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484 ++ + APE L + R+T D+WS G ++ E+ T G+ + G + LDQ++ ++ Sbjct: 189 RW---YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKG---SDHLDQLKEIMKV 241 Query: 485 PCPP 488 P Sbjct: 242 TGTP 245 >5D9K-A nrPDB Length = 330 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 61/242 (25%), Positives = 116/242 (47%), Gaps = 13/242 (5%) Query: 276 LGQGCFGEVWM----GTWNGTTRVAIKTLKPGTMSPEAFLQ---EAQVMKKLRHEKLVQL 328 LGQG FG+V++ + A+K LK T+ ++ E ++ ++ H +V+L Sbjct: 38 LGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKL 97 Query: 329 -YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 YA +E +Y++ +++ G L L E + A++A + ++ + ++ Sbjct: 98 HYAFQTEGKLYLILDFLRGGDLFTRLSKEV--MFTEEDVKFYLAELALALDHLHSLGIIY 155 Query: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 447 RDL+ NIL+ E K+ DFGL++ D+E A +++ APE T +D Sbjct: 156 RDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCG-TVEYMAPEVVNRRGHTQSAD 214 Query: 448 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPE 507 WSFG+L+ E+ T G +P+ G +E + + + ++ P L+ +++ P Sbjct: 215 WWSFGVLMFEMLT-GTLPFQGKDRKETMTMILKA-KLGMPQFLSPEAQSLLRMLFKRNPA 272 Query: 508 ER 509 R Sbjct: 273 NR 274 >3PFQ-A nrPDB Length = 674 Score = 80.5 bits (197), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 57/210 (27%), Positives = 108/210 (51%), Gaps = 11/210 (5%) Query: 276 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEAFLQEAQVMKKL-----RHEKLVQLY 329 LG+G FG+V + GT + A+K LK + + ++ V K++ + L QL+ Sbjct: 349 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 408 Query: 330 AVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 + + + +Y V EY++ G L+ ++ + G++ + P V AA+IA G+ +++ ++R Sbjct: 409 SCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRF-KEPHAVFYAAEIAIGLFFLQSKGIIYR 466 Query: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 448 DL+ N+++ K+ADFG+ + + T + P + APE Y + D Sbjct: 467 DLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDW 525 Query: 449 WSFGILLTELTTKGRVPYPGMVNREVLDQV 478 W+FG+LL E+ G+ P+ G E+ + Sbjct: 526 WAFGVLLYEMLA-GQAPFEGEDEDELFQSI 554 >2BRG-A nrPDB Length = 297 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 61/199 (30%), Positives = 93/199 (46%), Gaps = 13/199 (6%) Query: 276 LGQGCFGEVWMGTWNGT---TRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVV 332 LG+G +GEV + T V I +K PE +E + K L HE +V+ Y Sbjct: 15 LGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHENVVKFYGHR 74 Query: 333 SEEPI-YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLR 391 E I Y+ EY S G L D ++ + G + P Q+ +G+ Y+ + HRD++ Sbjct: 75 REGNIQYLFLEYCSGGELFDRIEPDIG--MPEPDAQRFFHQLMAGVVYLHGIGITHRDIK 132 Query: 392 AANILVGENLVCKVADFGLARLIEDNE---YTARQGAKFPIKWTAPEAALYGRFTIKS-D 447 N+L+ E K++DFGLA + N + P + APE F + D Sbjct: 133 PENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLP--YVAPELLKRREFHAEPVD 190 Query: 448 VWSFGILLTELTTKGRVPY 466 VWS GI+LT + G +P+ Sbjct: 191 VWSCGIVLTAMLA-GELPW 208 >3H4J-B nrPDB Length = 336 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 64/200 (32%), Positives = 103/200 (51%), Gaps = 17/200 (8%) Query: 276 LGQGCFGEVWMGT-WNGTTRVAIK-----TLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329 LG+G FG+V + T + +VA+K LK M +E +K LRH +++LY Sbjct: 17 LGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRV-EREISYLKLLRHPHIIKLY 75 Query: 330 AVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 V++ I +V EY + G L D++ + K + + QI + Y R VHR Sbjct: 76 DVITTPTDIVMVIEY-AGGELFDYIVEK--KRMTEDEGRRFFQQIICAIEYCHRHKIVHR 132 Query: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI--KS 446 DL+ N+L+ +NL K+ADFGL+ ++ D + + P + APE + G+ + Sbjct: 133 DLKPENLLLDDNLNVKIADFGLSNIMTDGNFL-KTSCGSP-NYAAPE-VINGKLYAGPEV 189 Query: 447 DVWSFGILLTELTTKGRVPY 466 DVWS GI+L + GR+P+ Sbjct: 190 DVWSCGIVLYVMLV-GRLPF 208 >2Z7Q-A nrPDB Length = 321 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 62/244 (25%), Positives = 117/244 (47%), Gaps = 17/244 (6%) Query: 276 LGQGCFGEVWMGTWNGTTR------VAIKTLKPGTMSPEAFLQ---EAQVMKKLRHEKLV 326 LGQG FG+V++ TR A+K LK T+ ++ E ++ + H +V Sbjct: 36 LGQGSFGKVFL--VRKVTRPDSGHLYAMKVLKKATLKVRDRVRTKMERDILADVNHPFVV 93 Query: 327 QL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 +L YA +E +Y++ +++ G L L E + A++A G+ ++ + Sbjct: 94 KLHYAFQTEGKLYLILDFLRGGDLFTRLSKEV--MFTEEDVKFYLAELALGLDHLHSLGI 151 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445 ++RDL+ NIL+ E K+ DFGL++ D+E A +++ APE + Sbjct: 152 IYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCG-TVEYMAPEVVNRQGHSHS 210 Query: 446 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKE 505 +D WS+G+L+ E+ T G +P+ G +E + + + ++ P L+ +++ Sbjct: 211 ADWWSYGVLMFEMLT-GSLPFQGKDRKETMTLILKA-KLGMPQFLSTEAQSLLRALFKRN 268 Query: 506 PEER 509 P R Sbjct: 269 PANR 272 >6AO5-A nrPDB Length = 362 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 64/252 (25%), Positives = 110/252 (43%), Gaps = 12/252 (4%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKL 325 P E + KLG+G +G V+ + +V P + ++E +M++ + Sbjct: 8 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQEIIKEISIMQQCDSPYV 67 Query: 326 VQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN 384 V+ Y + ++IV EY GS+ D ++ K L ++ + G+ Y+ M Sbjct: 68 VKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLR-NKTLIEDEIATILKSTLKGLEYLHFMR 126 Query: 385 YVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI 444 +HR+++A NIL+ K+ADFG+A + D P W APE + Sbjct: 127 KIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPF-WMAPEVIQEIGYNC 185 Query: 445 KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP----PEC-PESLHDLMC 499 +D+WS GI E+ +G+ PY + + + P P PE + D + Sbjct: 186 VADIWSLGITSIEM-AEGKPPYADIHPMRAIFMIPTN---PPPTFRKPELWSDDFTDFVK 241 Query: 500 QCWRKEPEERPT 511 +C K PE+R T Sbjct: 242 KCLVKNPEQRAT 253 >3GC9-A nrPDB Length = 370 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 74/269 (27%), Positives = 126/269 (46%), Gaps = 32/269 (11%) Query: 241 CHRLTTVCPTSKPQTQGLAKDAWEIPR--ESLRLEVKLGQGCFGEVWMGTWNGTTR--VA 296 H L P + Q L K WE+P+ + LR +G G +G V ++ R VA Sbjct: 2 SHMLEMSGPRAGFYRQELNKTVWEVPQRLQGLR---PVGSGAYGSV-CSAYDARLRQKVA 57 Query: 297 IKTL-KP--GTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE-------EPIYIVTEYMSK 346 +K L +P + +E +++K L+HE ++ L V + +Y+VT M Sbjct: 58 VKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMG- 116 Query: 347 GSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVA 406 L + +K + L + + Q+ G+ Y+ +HRDL+ +N+ V E+ ++ Sbjct: 117 ADLNNIVKSQA---LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRIL 173 Query: 407 DFGLARLIEDNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVP 465 DFGLAR D E T ++ + APE L + + D+WS G ++ EL +G+ Sbjct: 174 DFGLARQ-ADEEMTGYVATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAEL-LQGKAL 228 Query: 466 YPGMVNREVLDQVERGYRMPCPPECPESL 494 +PG + +DQ++R + P PE L Sbjct: 229 FPG---SDYIDQLKRIMEVVGTP-SPEVL 253 >5XZW-A nrPDB Length = 471 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 68/261 (26%), Positives = 120/261 (45%), Gaps = 33/261 (12%) Query: 276 LGQGCFGEVWMG---TWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVV 332 +GQG F V T T V I + + + + +E +V++KL H ++V+L Sbjct: 204 VGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFY 263 Query: 333 SE-EPIYIVTEYMSKGSLLDFL--KGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 + E Y+V E++S G L+DF+ G G+ +++ QI + + Y+ M HRD Sbjct: 264 EDTESYYMVMEFVSGGDLMDFVAAHGAVGE----DAGREISRQILTAIKYIHSMGISHRD 319 Query: 390 LRAANILVGEN--LVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS- 446 L+ NIL+ ++ ++ K+ DFGLA++ + + + + APE + G+ T S Sbjct: 320 LKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCG--TLAYVAPE-VIRGKDTSVSP 376 Query: 447 -------------DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE---C 490 D+WS G L+ + T G +P+ G ++ Q+ RG P + Sbjct: 377 DEYEERNEYSSLVDMWSMGCLVYVILT-GHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRI 435 Query: 491 PESLHDLMCQCWRKEPEERPT 511 E D + + +P R T Sbjct: 436 SEEARDFIDSLLQVDPNNRST 456 >6CQF-A nrPDB Length = 297 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 73/262 (27%), Positives = 121/262 (46%), Gaps = 26/262 (9%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPE----AFLQEAQVMKKL 320 PR+ L +LG G +GEV+ + VA+K +K M P+ +E ++K Sbjct: 14 PRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVK---MEPDDDVSTLQKEILILKTC 70 Query: 321 RHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 RH +V + + + + ++I E+ GSL D + TG L Q+ + ++ G+AY Sbjct: 71 RHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQ-VTGSLSEL-QISYVCREVLQGLAY 128 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIK-WTAPE--- 435 + +HRD++ ANIL+ + ++ADFG++ I AR+ A W APE Sbjct: 129 LHSQKKIHRDIKGANILINDAGEVRLADFGISAQI--GATLARRLAFIGTPYWMAPEVAA 186 Query: 436 AALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE--- 492 AL G + D+WS GI EL + R + + GY+ PP E Sbjct: 187 VALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQ---PPRLKEKGK 243 Query: 493 ---SLHDLMCQCWRKEPEERPT 511 + H+ + K P++RP+ Sbjct: 244 WSAAFHNFIKVTLTKSPKKRPS 265 >2F57-A nrPDB Length = 317 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 71/264 (26%), Positives = 121/264 (45%), Gaps = 28/264 (10%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLK-PGTMSPEAFLQEAQVMKKLRHE 323 PRE L +K+G+G G V + T T + VA+K + E E +M+ H+ Sbjct: 43 PREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHD 102 Query: 324 KLVQLYA--VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 +V +Y+ +V +E +++V E++ G+L D + T + Q+ + + ++Y+ Sbjct: 103 NVVDMYSSYLVGDE-LWVVMEFLEGGALTDIV---THTRMNEEQIATVCLSVLRALSYLH 158 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 +HRD+++ +IL+ + K++DFG + E R+ W APE Sbjct: 159 NQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQV-SKEVPKRKSLVGTPYWMAPEVISRLP 217 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLH------ 495 + + D+WS GI++ E+ G PY N L Q R R PP + LH Sbjct: 218 YGTEVDIWSLGIMVIEM-IDGEPPY---FNEPPL-QAMRRIRDSLPPRV-KDLHKVSSVL 271 Query: 496 ----DLMCQCWRKEPEERPTFEYL 515 DLM +EP +R T + L Sbjct: 272 RGFLDLMLV---REPSQRATAQEL 292 >2I0E-A nrPDB Length = 353 Score = 79.0 bits (193), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 57/210 (27%), Positives = 108/210 (51%), Gaps = 11/210 (5%) Query: 276 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEAFLQEAQVMKKL-----RHEKLVQLY 329 LG+G FG+V + GT + A+K LK + + ++ V K++ + L QL+ Sbjct: 28 LGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLH 87 Query: 330 AVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 + + + +Y V EY++ G L+ ++ + G++ + P V AA+IA G+ +++ ++R Sbjct: 88 SCFQTMDRLYFVMEYVNGGDLMYHIQ-QVGRF-KEPHAVFYAAEIAIGLFFLQSKGIIYR 145 Query: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 448 DL+ N+++ K+ADFG+ + + T + P + APE Y + D Sbjct: 146 DLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEIIAYQPYGKSVDW 204 Query: 449 WSFGILLTELTTKGRVPYPGMVNREVLDQV 478 W+FG+LL E+ G+ P+ G E+ + Sbjct: 205 WAFGVLLYEMLA-GQAPFEGEDEDELFQSI 233 >4EQM-A nrPDB Length = 294 Score = 78.6 bits (192), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 66/270 (24%), Positives = 127/270 (47%), Gaps = 19/270 (7%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTL----KPGTMSPEAFLQEAQVMK 318 +I E ++ KLG G V++ +VAIK + + + + F +E Sbjct: 7 KIINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSS 66 Query: 319 KLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 +L H+ +V + V E+ Y +V EY+ +L +++ E+ L + ++ QI G+ Sbjct: 67 QLSHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYI--ESHGPLSVDTAINFTNQILDGI 124 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 437 + M VHRD++ NIL+ N K+ DFG+A+ + + T +++ +PE A Sbjct: 125 KHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQA 184 Query: 438 LYGRFTIK-SDVWSFGILLTELTTKGRVPYPG-----MVNREVLDQVERGYRMPCPPECP 491 G T + +D++S GI+L E+ G P+ G + + + D V + P Sbjct: 185 -KGEATDECTDIYSIGIVLYEMLV-GEPPFNGETAVSIAIKHIQDSVP-NVTTDVRKDIP 241 Query: 492 ESLHDLMCQCWRKEPEERPTFEYLQAFLED 521 +SL +++ + K+ R ++ +Q +D Sbjct: 242 QSLSNVILRATEKDKANR--YKTIQEMKDD 269 >6CMJ-A nrPDB Length = 321 Score = 78.6 bits (192), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 72/270 (26%), Positives = 130/270 (48%), Gaps = 27/270 (10%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMG-TWNGTTRVAIKTLKP--------GTMSP--- 307 +D ++ + +L+ E+ G+G +G V + N T A+K L G + P Sbjct: 28 QDCVQLDQYTLKDEI--GKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGP 85 Query: 308 -EAFLQEAQVMKKLRHEKLVQLYAVV---SEEPIYIVTEYMSKGSLLDFLKGETGKYLRL 363 E QE ++KKL H +V+L V+ +E+ +Y+V E +++G +++ T K L Sbjct: 86 IEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEV---PTLKPLSE 142 Query: 364 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 423 Q + G+ Y+ +HRD++ +N+LVGE+ K+ADFG++ + ++ Sbjct: 143 DQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSN 202 Query: 424 GAKFPIKWTAPEAALYGR--FTIKS-DVWSFGILLTELTTKGRVPYPGMVNREVLDQVE- 479 P + APE+ R F+ K+ DVW+ G+ L G+ P+ + +++ Sbjct: 203 TVGTP-AFMAPESLSETRKIFSGKALDVWAMGVTLYCFVF-GQCPFMDERIMCLHSKIKS 260 Query: 480 RGYRMPCPPECPESLHDLMCQCWRKEPEER 509 + P P+ E L DL+ + K PE R Sbjct: 261 QALEFPDQPDIAEDLKDLITRMLDKNPESR 290 >3Q4U-A nrPDB Length = 301 Score = 78.2 bits (191), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 81/297 (27%), Positives = 132/297 (44%), Gaps = 63/297 (21%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKK--LRH 322 + R+ LE +G+G +GEVW G+W G VA+K + +++ +E ++ LRH Sbjct: 6 VARDITLLEC-VGKGRYGEVWRGSWQGEN-VAVKIF--SSRDEKSWFRETELYNTVMLRH 61 Query: 323 EKLVQLYAV-----VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 E ++ A S ++++T Y GSL D+L+ T L + + IASG+ Sbjct: 62 ENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTT---LDTVSCLRIVLSIASGL 118 Query: 378 AYVE--------RMNYVHRDLRAANILVGENLVCKVADFGLARLIE------DNEYTARQ 423 A++ + HRDL++ NILV +N C +AD GLA + D R Sbjct: 119 AHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRV 178 Query: 424 GAKFPIKWTAPEAA-------LYGRFTIKSDVWSFGILLTE----LTTKGRV-----PYP 467 G K ++ APE + + + D+W+FG++L E + + G V P+ Sbjct: 179 GTK---RYMAPEVLDETIQVDCFDSYK-RVDIWAFGLVLWEVARRMVSNGIVEDYKPPFY 234 Query: 468 GMVNREVLDQVERGYRMPCP----PECPE---------SLHDLMCQCWRKEPEERPT 511 +V + E ++ C P P SL LM +CW + P R T Sbjct: 235 DVVPND--PSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLT 289 >2F9G-A nrPDB Length = 353 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 64/226 (28%), Positives = 106/226 (46%), Gaps = 24/226 (10%) Query: 269 SLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAF--LQEAQVMKKLRHEKL 325 +L+ LG+G +G V T T VAIK ++P A L+E +++K +HE + Sbjct: 12 DFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREIKILKHFKHENI 71 Query: 326 VQLYAVVSEEP------IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 + ++ + + +YI+ E M D + + + L + Q + Sbjct: 72 ITIFNIQRPDSFENFNEVYIIQELMQT----DLHRVISTQMLSDDHIQYFIYQTLRAVKV 127 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLI-----EDNEYTARQGAK---FPIKW 431 + N +HRDL+ +N+L+ N KV DFGLAR+I +++E T +Q +W Sbjct: 128 LHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGMTEYVATRW 187 Query: 432 -TAPEAALY-GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVL 475 APE L +++ DVWS G +L EL + R +PG R L Sbjct: 188 YRAPEVMLTSAKYSRAMDVWSCGCILAELFLR-RPIFPGRDYRHQL 232 >3MN3-A nrPDB Length = 271 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 61/203 (30%), Positives = 104/203 (51%), Gaps = 23/203 (11%) Query: 276 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFL----QEAQVMKKLRHEKLVQLYA 330 LG+G FG+V + T +VA+K + ++ +E ++ LRH +++LY Sbjct: 12 LGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRHPHIIKLYD 71 Query: 331 VV-SEEPIYIVTEYMSKGSLLDFL----KGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 V+ S++ I +V EY + L D++ K + R Q QI S + Y R Sbjct: 72 VIKSKDEIIMVIEY-AGNELFDYIVQRDKMSEQEARRFFQ------QIISAVEYCHRHKI 124 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI- 444 VHRDL+ N+L+ E+L K+ADFGL+ ++ D + + P + APE + G+ Sbjct: 125 VHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFL-KTSCGSP-NYAAPE-VISGKLYAG 181 Query: 445 -KSDVWSFGILLTELTTKGRVPY 466 + DVWS G++L + + R+P+ Sbjct: 182 PEVDVWSCGVILYVMLCR-RLPF 203 >1PY5-A nrPDB Length = 326 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 51/159 (32%), Positives = 87/159 (54%), Gaps = 23/159 (14%) Query: 269 SLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKK--LRHEKLV 326 ++ L+ +G+G FGEVW G W G VA+K + ++ +EA++ + LRHE ++ Sbjct: 30 TIVLQESIGKGRFGEVWRGKWRGE-EVAVKIF--SSREERSWFREAEIYQTVMLRHENIL 86 Query: 327 QLYAVVSEE-----PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 A +++ +++V++Y GSL D+L T + + ++ +A ASG+A++ Sbjct: 87 GFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT---VTVEGMIKLALSTASGLAHLH 143 Query: 382 RMNYV---------HRDLRAANILVGENLVCKVADFGLA 411 M V HRDL++ NILV +N C +AD GLA Sbjct: 144 -MEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLA 181 >4D28-A nrPDB Length = 446 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 75/253 (29%), Positives = 118/253 (46%), Gaps = 36/253 (14%) Query: 276 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFL----QEAQVMKKLRHEKLVQLYA 330 +G+G F +V T VAIK + T+ + +E +MK +RH +V+LY Sbjct: 17 IGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPNIVRLYE 76 Query: 331 VV-SEEPIYIVTEYMSKGSLLDFL--KG-----ETGKYLRLPQLVDMAAQIASGMAYVER 382 V+ S+ IYIV E+++ G L D + KG E+ KY + QLVD A S Y Sbjct: 77 VLASKSKIYIVLEFVTGGELFDRIVHKGRLKEDESRKYFQ--QLVDAVAHCHSKGVY--- 131 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA-ALYGR 441 HRDL+ N+L+ N KV+DFGL+ L ++ P + APE + G Sbjct: 132 ----HRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTP-NYVAPEVLSGQGY 186 Query: 442 FTIKSDVWSFGILLTELTTKGRVPY-----PGMVNREVLDQVERGYRMPCPPECPESLHD 496 +D+WS G++L + G +P+ PG+ + ++ E CPP + Sbjct: 187 DGSAADIWSCGVILF-VILAGYLPFSETDLPGLYRK--INAAE----FDCPPWFSAEVKF 239 Query: 497 LMCQCWRKEPEER 509 L+ + P+ R Sbjct: 240 LIHRILDPNPKTR 252 >5TQX-A nrPDB Length = 655 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 61/196 (31%), Positives = 94/196 (47%), Gaps = 15/196 (7%) Query: 275 KLGQGCFGEVWMGTWNGT-TRVAIKT--LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAV 331 +LG G FG V + ++AIK+ L+ T + E + E Q+MKKL H +V+ V Sbjct: 15 RLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVVKACDV 74 Query: 332 VSEEPIYI------VTEYMSKGSLLDFL-KGETGKYLRLPQLVDMAAQIASGMAYVERMN 384 E I I EY S G L L K E L+ Q++ + + I SG+ Y+ Sbjct: 75 PEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHENK 134 Query: 385 YVHRDLRAANIL---VGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 +HRDL+ NI+ VG ++ K+ D G A+ ++ E +++ APE Sbjct: 135 IIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVG--TLQYLAPELFENKP 192 Query: 442 FTIKSDVWSFGILLTE 457 +T D WSFG ++ E Sbjct: 193 YTATVDYWSFGTMVFE 208 >4PDS-A nrPDB Length = 347 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 67/261 (25%), Positives = 119/261 (45%), Gaps = 33/261 (12%) Query: 276 LGQGCFGEVWMG---TWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVV 332 +GQG F V T T V I + + + + +E +V++KL H ++V+L Sbjct: 39 VGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRLKGFY 98 Query: 333 SE-EPIYIVTEYMSKGSLLDFL--KGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 + E Y+V E++S G L+DF+ G G+ +++ QI + + Y+ M HRD Sbjct: 99 EDTESYYMVMEFVSGGDLMDFVAAHGAVGE----DAGREISRQILTAIKYIHSMGISHRD 154 Query: 390 LRAANILVGEN--LVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS- 446 L+ NIL+ ++ ++ K+ FGLA++ + + + + APE + G+ T S Sbjct: 155 LKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCG--TLAYVAPE-VIRGKDTSVSP 211 Query: 447 -------------DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE---C 490 D+WS G L+ + T G +P+ G ++ Q+ RG P + Sbjct: 212 DEYEERNEYSSLVDMWSMGCLVYVILT-GHLPFSGSTQDQLYKQIGRGSYHEGPLKDFRI 270 Query: 491 PESLHDLMCQCWRKEPEERPT 511 E D + + +P R T Sbjct: 271 SEEARDFIDSLLQVDPNNRST 291 >6BFN-A nrPDB Length = 342 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 75/306 (24%), Positives = 123/306 (40%), Gaps = 59/306 (19%) Query: 273 EVKLGQGCFGEVWMGTWNGTTRVAIKTLKPG-----TMSPEAFLQEAQVMKKLRHEKLVQ 327 E+K+G+G FG V+ T A+K LK T ++FL E + + + RH +V Sbjct: 27 ELKIGEGGFGCVYRAVMRNTV-YAVKRLKENADLEWTAVKQSFLTEVEQLSRFRHPNIVD 85 Query: 328 LYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKY--LRLPQLVDMAAQIASGMAYVER-- 382 ++ Y +V ++ GSL D L +T L PQ +D+ A + ++ + Sbjct: 86 FAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFLHQDS 145 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIE-------DNEYTAR-QGAKFPIKWTAP 434 + +H D++++N+L+ E L K+ DFGLAR + AR Q + + + Sbjct: 146 PSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTLAYLPE 205 Query: 435 EAALYGRFTIKSDVWSFGILLTE-LTTKGRVPYPGMVNREVLDQVERGYRM--------- 484 E GR + +D +SFG+++ E L + V G + + D VE Sbjct: 206 EYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVALRSTQ 265 Query: 485 ------------------------------PCPPECPESLHDLMCQCWRKEPEERPTFEY 514 PCPPE L L C C + + RP Sbjct: 266 STLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRRPPMTQ 325 Query: 515 LQAFLE 520 + LE Sbjct: 326 VYERLE 331 >4U41-A nrPDB Length = 332 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 60/222 (27%), Positives = 103/222 (46%), Gaps = 24/222 (10%) Query: 259 AKDAWEIPRESLR--------LEVKLGQGCFGEVWMGTWNGTTRVA-IKTLKPGTMSPEA 309 AK +I SLR +EV +G G +G+V+ G T ++A IK + E Sbjct: 8 AKSLVDIDLSSLRDPAGIFELVEV-VGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEE 66 Query: 310 FLQEAQVMKKLRHEKLVQLY--AVVSEEP------IYIVTEYMSKGSLLDFLKGETGKYL 361 E ++KK H + + Y A + + P +++V E+ GS+ D +K G L Sbjct: 67 IKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTL 126 Query: 362 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA 421 + + ++ +I G+A++ + +HRD++ N+L+ EN K+ DFG++ + D Sbjct: 127 KEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQL-DRTVGR 185 Query: 422 RQGAKFPIKWTAPEAALY-----GRFTIKSDVWSFGILLTEL 458 R W APE + +SD+WS GI E+ Sbjct: 186 RNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEM 227 >1V0B-A nrPDB Length = 288 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 63/227 (27%), Positives = 111/227 (48%), Gaps = 28/227 (12%) Query: 275 KLGQGCFGEVWMGTWNGTTRVAIKTL---KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAV 331 K+G+G +G V+ N A+K + K P ++E ++K+L+H +V+LY V Sbjct: 9 KIGEGTYGVVYKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHSNIVKLYDV 68 Query: 332 V-SEEPIYIVTEYMSKG--SLLDFLKG----ETGKYLRLPQLVDMAAQIASGMAYVERMN 384 + +++ + +V E++ + LLD +G T K L Q+ +G+AY Sbjct: 69 IHTKKRLVLVFEHLDQDLKKLLDVCEGGLESVTAKSFLL--------QLLNGIAYCHDRR 120 Query: 385 YVHRDLRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAAL-YGR 441 +HRDL+ N+L+ K+ADFGLAR I +YT + + AP+ + + Sbjct: 121 VLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEV---VTLWYRAPDVLMGSKK 177 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP 488 ++ D+WS G + E+ G +PG+ DQ+ R +R+ P Sbjct: 178 YSTTIDIWSVGCIFAEMVN-GAPLFPGVSEA---DQLMRIFRILGTP 220 >3MY0-A nrPDB Length = 305 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 61/218 (27%), Positives = 106/218 (48%), Gaps = 40/218 (18%) Query: 276 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKK--LRHEKLVQLYAV-- 331 +G+G +GEVW G W+G + VA+K + +++ +E ++ LRH+ ++ A Sbjct: 16 VGKGRYGEVWRGLWHGES-VAVKIF--SSRDEQSWFRETEIYNTVLLRHDNILGFIASDM 72 Query: 332 ---VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQL-VDMAAQIASGMAYVE------ 381 S ++++T Y GSL DFL+ +T + P L + +A A G+A++ Sbjct: 73 TSRNSSTQLWLITHYHEHGSLYDFLQRQTLE----PHLALRLAVSAACGLAHLHVEIFGT 128 Query: 382 --RMNYVHRDLRAANILVGENLVCKVADFGLARLIE------DNEYTARQGAKFPIKWTA 433 + HRD ++ N+LV NL C +AD GLA + D R G K ++ A Sbjct: 129 QGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTK---RYMA 185 Query: 434 PEAA-------LYGRFTIKSDVWSFGILLTELTTKGRV 464 PE + + +D+W+FG++L E+ + V Sbjct: 186 PEVLDEQIRTDCFESYKW-TDIWAFGLVLWEIARRTIV 222 >3MIA-A nrPDB Length = 351 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 101/209 (48%), Gaps = 23/209 (11%) Query: 275 KLGQGCFGEVWMGTWNGT-TRVAIKTL-----KPGTMSPEAFLQEAQVMKKLRHEKLVQL 328 K+GQG FGEV+ T +VA+K + K G P L+E ++++ L+HE +V L Sbjct: 24 KIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGF--PITALREIKILQLLKHENVVNL 81 Query: 329 YAVVSEEP---------IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 + + IY+V ++ + L L K+ L ++ + + +G+ Y Sbjct: 82 IEICRTKASPYNRCKGSIYLVFDF-CEHDLAGLLSNVLVKF-TLSEIKRVMQMLLNGLYY 139 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAA 437 + R +HRD++AAN+L+ + V K+ADFGLAR + N R + W P Sbjct: 140 IHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPEL 199 Query: 438 LYGR--FTIKSDVWSFGILLTELTTKGRV 464 L G + D+W G ++ E+ T+ + Sbjct: 200 LLGERDYGPPIDLWGAGCIMAEMWTRSPI 228 >3ORP-A nrPDB Length = 311 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 71/251 (28%), Positives = 109/251 (43%), Gaps = 22/251 (8%) Query: 276 LGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFL----QEAQVMKKLRHEKLVQLYA 330 LG G EV + R VA+K L+ +F +EAQ L H +V +Y Sbjct: 20 LGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNHPAIVAVYD 79 Query: 331 VVSEE----PI-YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 E P+ YIV EY+ +L D + E + + +++ A + + + Sbjct: 80 TGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPK--RAIEVIADACQALNFSHQNGI 137 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKF--PIKWTAPEAALYGRFT 443 +HRD++ ANI++ KV DFG+AR I D+ + Q A ++ +PE A Sbjct: 138 IHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPEQARGDSVD 197 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC-----PESLHDLM 498 +SDV+S G +L E+ T G P+ G V Q R P PP L ++ Sbjct: 198 ARSDVYSLGCVLYEVLT-GEPPFTGDSPVSVAYQHVR--EDPIPPSARHEGLSADLDAVV 254 Query: 499 CQCWRKEPEER 509 + K PE R Sbjct: 255 LKALAKNPENR 265 >4MYG-A nrPDB Length = 372 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 70/275 (25%), Positives = 130/275 (47%), Gaps = 24/275 (8%) Query: 256 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQEA 314 Q + K AWE+P+ + +G G +G V + +VAIK L S E F + A Sbjct: 32 QDVNKTAWELPKTYVS-PTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQS-EIFAKRA 89 Query: 315 Q----VMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP----QL 366 ++K ++HE ++ L V + P + + ++ F++ + K + + ++ Sbjct: 90 YRELLLLKHMQHENVIGLLDVFT--PASSLRNFYDFYLVMPFMQTDLQKIMGMEFSEEKI 147 Query: 367 VDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK 426 + Q+ G+ Y+ VHRDL+ N+ V E+ K+ DFGLAR D E T + Sbjct: 148 QYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH-ADAEMTGYVVTR 206 Query: 427 FPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP 485 + + APE L + + D+WS G ++ E+ T G+ + G ++ LDQ+ + ++ Sbjct: 207 W---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKG---KDYLDQLTQILKVT 259 Query: 486 CPP--ECPESLHDLMCQCWRKEPEERPTFEYLQAF 518 P E + L+D + + + + P ++ Q F Sbjct: 260 GVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLF 294 >4KS7-A nrPDB Length = 292 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 67/260 (25%), Positives = 120/260 (46%), Gaps = 20/260 (7%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLK-PGTMSPEAFLQEAQVMKKLRHE 323 PR L VK+G+G G V + + R VA+K + E E +M+ +H Sbjct: 21 PRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHF 80 Query: 324 KLVQLYA--VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 +V++Y +V EE ++++ E++ G+L D + + L Q+ + + +AY+ Sbjct: 81 NVVEMYKSYLVGEE-LWVLMEFLQGGALTDIV---SQVRLNEEQIATVCEAVLQALAYLH 136 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 +HRD+++ +IL+ + K++DFG I + + P W APE Sbjct: 137 AQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPY-WMAPEVISRSL 195 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES------LH 495 + + D+WS GI++ E+ G PY + V Q + R PP+ S L Sbjct: 196 YATEVDIWSLGIMVIEM-VDGEPPY--FSDSPV--QAMKRLRDSPPPKLKNSHKVSPVLR 250 Query: 496 DLMCQCWRKEPEERPTFEYL 515 D + + ++P+ER T + L Sbjct: 251 DFLERMLVRDPQERATAQEL 270 >4BBM-A nrPDB Length = 331 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 77/280 (27%), Positives = 122/280 (43%), Gaps = 58/280 (20%) Query: 276 LGQGCFGEVWMGTWNGTTR-VAIKTL---KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAV 331 +G+G +G V T R VAIK M + ++E +++K+LRHE LV L V Sbjct: 33 VGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEV 92 Query: 332 VSEEPI-YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDL 390 ++ Y+V E++ L D G ++ Q QI +G+ + N +HRD+ Sbjct: 93 CKKKKRWYLVFEFVDHTILDDLELFPNGLDYQVVQ--KYLFQIINGIGFCHSHNIIHRDI 150 Query: 391 RAANILVGENLVCKVADFGLARL------IEDNEYTARQGAKFPIKWTAPEAAL----YG 440 + NILV ++ V K+ DFG AR + D+E R + APE + YG Sbjct: 151 KPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRW-------YRAPELLVGDVKYG 203 Query: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVL--------------------DQVER 480 + DVW+ G L+TE+ G +PG + + L + V Sbjct: 204 K---AVDVWAIGCLVTEMFM-GEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFA 259 Query: 481 GYRMPCP----------PECPESLHDLMCQCWRKEPEERP 510 G R+P P+ E + DL +C +P++RP Sbjct: 260 GVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRP 299 >4M69-B nrPDB Length = 283 Score = 75.1 bits (183), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 66/271 (24%), Positives = 129/271 (47%), Gaps = 29/271 (10%) Query: 264 EIPRESLRLE-VKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---------FLQE 313 EIP+E L KL ++ G ++ + V IK +P+A F E Sbjct: 4 EIPKEHLGPPWTKLKTSKMSTIYRGEYHRSP-VTIKVFN----NPQAESVGIVRFTFNDE 58 Query: 314 AQVMKKLRHEKLVQLYAVVSEEPIY-----IVTEYMSKGSLLDFLKGETGKYLRLPQLVD 368 + MKK +++++ + ++ + IV EY G+L + L E + + L+ Sbjct: 59 IKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLV 118 Query: 369 MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGA--- 425 + A A G+ + +HR++ +++ LV K+A F L++ TA+ Sbjct: 119 LRA--ARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAER 176 Query: 426 KFPIKWTAPEAAL--YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGY 482 + +PE + + IK++++SFGI+L E+ T G++P+ G ++++ + V E Sbjct: 177 SSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIAT-GKIPFEGCDSKKIRELVAEDKK 235 Query: 483 RMPCPPECPESLHDLMCQCWRKEPEERPTFE 513 + P +CPE L +++ +C EP +RP+ + Sbjct: 236 QEPVGQDCPELLREIINECRAHEPSQRPSVD 266 >5J5T-A nrPDB Length = 370 Score = 74.7 bits (182), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 74/278 (26%), Positives = 123/278 (44%), Gaps = 28/278 (10%) Query: 267 RESLRLEVKLGQGCFGEVWMG-TWNGTTRVAIKTLK--PGTMSPEAFL---QEAQVMKKL 320 +E L ++G G +G+V+ N AIK +K PG E F QE +MK Sbjct: 3 QEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPG----EDFAVVQQEIIMMKDC 58 Query: 321 RHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 +H +V + + + + ++I E+ GSL D + TG L Q+ ++ + G+ Y Sbjct: 59 KHPNIVAYFGSYLRRDKLWICMEFCGGGSLQD-IYHVTGPLSEL-QIAYVSRETLQGLYY 116 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 + +HRD++ ANIL+ +N K+ADFG++ I + P W APE A Sbjct: 117 LHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPY-WMAPEVAAV 175 Query: 440 GR---FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE---- 492 R + D+W+ GI EL + R + + ++ PP+ + Sbjct: 176 ERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQ---PPKLKDKMKW 232 Query: 493 --SLHDLMCQCWRKEPEERPTFEYL--QAFLEDYFTST 526 S H + K P++RPT E L F+ + T + Sbjct: 233 SNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRS 270 >6CCF-A nrPDB Length = 290 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 62/218 (28%), Positives = 107/218 (49%), Gaps = 30/218 (13%) Query: 308 EAFLQEAQVMKKLRHEKLVQLYAVV---SEEPIYIVTEYMSKGSLLD------FLKGETG 358 E QE ++KKL H +V+L V+ +E+ +Y+V + + KG +++ F + + Sbjct: 73 ERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVMEVPCDKPFSEEQAR 132 Query: 359 KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE 418 YLR + G+ Y+ VHRD++ +N+L+G++ K+ADFG++ E N+ Sbjct: 133 LYLR---------DVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQFEGND 183 Query: 419 YTARQGAKFPIKWTAPEAALYG--RFTIKS-DVWSFGILLTELTTKGRVPYPG----MVN 471 A P + APEA F+ K+ DVW+ G+ L G+ P+ ++ Sbjct: 184 AQLSSTAGTP-AFMAPEAISDSGQSFSGKALDVWATGVTLYCFVY-GKCPFIDDFILALH 241 Query: 472 REVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEER 509 R++ ++ P PE E L DL+ + K PE R Sbjct: 242 RKIKNE---PVVFPEEPEISEELKDLILKMLDKNPETR 276 >4BTF-A nrPDB Length = 469 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 53/216 (24%), Positives = 108/216 (50%), Gaps = 14/216 (6%) Query: 309 AFLQEAQVMKKLRHEKLVQLYAVVSEEPIY-----IVTEYMSKGSLLDFLKGETGKYLRL 363 F E + MKK +++++ + ++ + IV EY G+L + L E + + Sbjct: 240 TFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSV 299 Query: 364 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 423 L+ + A A G+ + +HR++ +++ LV K+A F L++ TA+ Sbjct: 300 RSLLVLRA--ARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKS 357 Query: 424 GA---KFPIKWTAPEAAL--YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 + +PE + + IK++++SFGI+L E+ T G++P+ G ++++ + V Sbjct: 358 TKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIAT-GKIPFEGCDSKKIRELV 416 Query: 479 -ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFE 513 E + P +CPE L +++ +C EP +RP+ + Sbjct: 417 AEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVD 452 >3ZDU-A nrPDB Length = 325 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 65/223 (29%), Positives = 107/223 (47%), Gaps = 37/223 (16%) Query: 275 KLGQGCFGEVWMGTWNGTTR-VAIKTL--KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAV 331 K+G+G +G V T + VAIK +P + ++E + +K+ HE LV L V Sbjct: 10 KVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLVNLIEV 69 Query: 332 VSEEP-IYIVTEYMSKGSLLDFLK----GETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 ++ I++V E++ ++LD L+ G K LR QI + Y+ N + Sbjct: 70 FRQKKKIHLVFEFIDH-TVLDELQHYCHGLESKRLR-----KYLFQILRAIDYLHSNNII 123 Query: 387 HRDLRAANILVGENLVCKVADFGLARL------IEDNEYTARQGAKFPIKWTAPEAAL-- 438 HRD++ NILV ++ + K+ DFG AR I D+E R + APE L Sbjct: 124 HRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRW-------YRAPELVLKD 176 Query: 439 --YGRFTIKSDVWSFGILLTELTTKGRVPY-PGMVNREVLDQV 478 YG+ D+W+ G ++ E+ T PY P + ++L ++ Sbjct: 177 TSYGK---PVDIWALGCMIIEMATGN--PYLPSSSDLDLLHKI 214 >1KOA-A nrPDB Length = 491 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 61/213 (28%), Positives = 96/213 (45%), Gaps = 15/213 (7%) Query: 275 KLGQGCFGEVWMGT--WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY-AV 331 +LG G FG V T G A + P E +E Q M LRH LV L+ A Sbjct: 58 ELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLRHPTLVNLHDAF 117 Query: 332 VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLR 391 + + ++ E+MS G L + + E K + + V+ Q+ G+ ++ NYVH DL+ Sbjct: 118 EDDNEMVMIYEFMSGGELFEKVADEHNK-MSEDEAVEYMRQVCKGLCHMHENNYVHLDLK 176 Query: 392 AANIL--VGENLVCKVADFGLARLIEDNEYTARQGAKFPI---KWTAPEAALYGRFTIKS 446 NI+ + K+ DFGL ++ +Q K ++ APE A + Sbjct: 177 PENIMFTTKRSNELKLIDFGLTAHLD-----PKQSVKVTTGTAEFAAPEVAEGKPVGYYT 231 Query: 447 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVE 479 D+WS G+ L+ + G P+ G + E L V+ Sbjct: 232 DMWSVGV-LSYILLSGLSPFGGENDDETLRNVK 263 >4FIE-A nrPDB Length = 423 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 52/205 (25%), Positives = 99/205 (48%), Gaps = 10/205 (4%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLK-PGTMSPEAFLQEAQVMKKLRHE 323 PR L +K+G+G G V + T + + VA+K + E E +M+ +HE Sbjct: 149 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE 208 Query: 324 KLVQLYA--VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 +V++Y +V +E +++V E++ G+L D + T + Q+ + + ++ + Sbjct: 209 NVVEMYNSYLVGDE-LWVVMEFLEGGALTDIV---THTRMNEEQIAAVCLAVLQALSVLH 264 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 +HRD+++ +IL+ + K++DFG + E R+ W APE Sbjct: 265 AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQV-SKEVPRRKSLVGTPYWMAPELISRLP 323 Query: 442 FTIKSDVWSFGILLTELTTKGRVPY 466 + + D+WS GI++ E+ G PY Sbjct: 324 YGPEVDIWSLGIMVIEM-VDGEPPY 347 >5YV8-A nrPDB Length = 298 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 73/290 (25%), Positives = 132/290 (45%), Gaps = 42/290 (14%) Query: 255 TQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMG-TWNGTTRVAIKTLKP----------- 302 + G + D ++ + +L+ E+ G+G +G V + N T A+K L Sbjct: 2 SSGSSGDCVQLNQYTLKDEI--GKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPR 59 Query: 303 ------------GTMSP----EAFLQEAQVMKKLRHEKLVQLYAVV---SEEPIYIVTEY 343 G + P E QE ++KKL H +V+L V+ +E+ +Y+V E Sbjct: 60 RPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFEL 119 Query: 344 MSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC 403 +++G +++ T K L Q + G+ Y+ +HRD++ +N+LVGE+ Sbjct: 120 VNQGPVMEV---PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHI 176 Query: 404 KVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR--FTIKS-DVWSFGILLTELTT 460 K+ADFG++ + ++ P + APE+ R F+ K+ DVW+ G+ L Sbjct: 177 KIADFGVSNEFKGSDALLSNTVGTP-AFMAPESLSETRKIFSGKALDVWAMGVTLYCFVF 235 Query: 461 KGRVPYPGMVNREVLDQVE-RGYRMPCPPECPESLHDLMCQCWRKEPEER 509 G+ P+ + +++ + P P+ E L DL+ + K PE R Sbjct: 236 -GQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESR 284 >3F3Z-A nrPDB Length = 277 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 72/266 (27%), Positives = 118/266 (44%), Gaps = 27/266 (10%) Query: 272 LEVKLGQGCFGEVWMGTWNGTT--RVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329 LE +G+G +GEV + GT R A K K + F QE ++MK L H +++LY Sbjct: 13 LENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIMKSLDHPNIIRLY 72 Query: 330 AVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 + IY+V E + G L F + + R + + S +AY ++N HR Sbjct: 73 ETFEDNTDIYLVMELCTGGEL--FERVVHKRVFRESDAARIMKDVLSAVAYCHKLNVAHR 130 Query: 389 DLRAANILV---GENLVCKVADFGL-ARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI 444 DL+ N L + K+ DFGL AR + G + + +P+ L G + Sbjct: 131 DLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPY---YVSPQ-VLEGLYGP 186 Query: 445 KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMP------CPPECPESLHDL 497 + D WS G+++ L G P+ + EV+ ++ G + P P+ + L Sbjct: 187 ECDEWSAGVMMYVLLC-GYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVSPQAESLIRRL 245 Query: 498 MCQCWRKEPEERPTFEYLQAFLEDYF 523 + K P++R T LQA ++F Sbjct: 246 LT----KSPKQRIT--SLQALEHEWF 265 >2OU7-A nrPDB Length = 335 Score = 73.6 bits (179), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 63/256 (24%), Positives = 111/256 (43%), Gaps = 13/256 (5%) Query: 276 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTM-----SPEAFLQEAQVMKKLRHEKLVQLYA 330 LG+G F + + + T V + P ++ E E + + L H+ +V + Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 331 VVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 + +++V E + SLL+ K K L P+ QI G Y+ R +HRD Sbjct: 109 FFEDNDFVFVVLELCRRRSLLELHKRR--KALTEPEARYYLRQIVLGCQYLHRNRVIHRD 166 Query: 390 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 449 L+ N+ + E+L K+ DFGLA +E + + P + APE + + DVW Sbjct: 167 LKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTP-NYIAPEVLSKKGHSFEVDVW 225 Query: 450 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEER 509 S G ++ L G+ P+ +E ++++ P L+ + + +P R Sbjct: 226 SIGCIMYTLLV-GKPPFETSCLKETYLRIKKN-EYSIPKHINPVAASLIQKMLQTDPTAR 283 Query: 510 PTFEYLQAFLEDYFTS 525 PT L +++FTS Sbjct: 284 PTINELLN--DEFFTS 297 >3UTO-A nrPDB Length = 573 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 61/213 (28%), Positives = 96/213 (45%), Gaps = 15/213 (7%) Query: 275 KLGQGCFGEVWMGT--WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY-AV 331 +LG G FG V T G A + P E +E Q M LRH LV L+ A Sbjct: 164 ELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLRHPTLVNLHDAF 223 Query: 332 VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLR 391 + + ++ E+MS G L + + E K + + V+ Q+ G+ ++ NYVH DL+ Sbjct: 224 EDDNEMVMIYEFMSGGELFEKVADEHNK-MSEDEAVEYMRQVCKGLCHMHENNYVHLDLK 282 Query: 392 AANIL--VGENLVCKVADFGLARLIEDNEYTARQGAKFPI---KWTAPEAALYGRFTIKS 446 NI+ + K+ DFGL ++ +Q K ++ APE A + Sbjct: 283 PENIMFTTKRSNELKLIDFGLTAHLD-----PKQSVKVTTGTAEFAAPEVAEGKPVGYYT 337 Query: 447 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVE 479 D+WS G+ L+ + G P+ G + E L V+ Sbjct: 338 DMWSVGV-LSYILLSGLSPFGGENDDETLRNVK 369 >2J90-A nrPDB Length = 304 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 69/274 (25%), Positives = 119/274 (43%), Gaps = 30/274 (10%) Query: 256 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP------- 307 Q + +D +E+ E LG G F V GT + A K +K +S Sbjct: 21 QSMVEDHYEMGEE-------LGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSR 73 Query: 308 EAFLQEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQL 366 E +E +++++RH ++ L+ + ++ + ++ E +S G L DFL + L + Sbjct: 74 EEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKES--LTEDEA 131 Query: 367 VDMAAQIASGMAYVERMNYVHRDLRAANILVGENLV----CKVADFGLARLIE-DNEYTA 421 QI G+ Y+ H DL+ NI++ + V K+ DFG+A IE NE+ Sbjct: 132 TQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKN 191 Query: 422 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQ---V 478 G ++ APE Y +++D+WS G+ +T + G P+ G +E L V Sbjct: 192 IFGTP---EFVAPEIVNYEPLGLEADMWSIGV-ITYILLSGASPFLGETKQETLTNISAV 247 Query: 479 ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTF 512 + E D + + K+P+ R T Sbjct: 248 NYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTI 281 >2XNP-A nrPDB Length = 279 Score = 73.2 bits (178), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 59/252 (23%), Positives = 112/252 (44%), Gaps = 16/252 (6%) Query: 276 LGQGCFGEVWMGTWNGTTRVAI-KTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLYAV 331 +G G +G ++ + K L G+M+ + + E ++++L+H +V+ Y Sbjct: 14 IGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHPNIVRYYDR 73 Query: 332 V---SEEPIYIVTEYMSKGSLLDFLKGETG--KYLRLPQLVDMAAQIASGMAYVERMN-- 384 + + +YIV EY G L + T +YL ++ + Q+ + R + Sbjct: 74 IIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRRSDG 133 Query: 385 ---YVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 +HRDL+ AN+ + K+ DFGLAR++ + A+ P + +PE Sbjct: 134 GHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPY-YMSPEQMNRMS 192 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 501 + KSD+WS G LL EL P+ +E+ ++ G P + L++++ + Sbjct: 193 YNEKSDIWSLGCLLYELCAL-MPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRM 251 Query: 502 WRKEPEERPTFE 513 + RP+ E Sbjct: 252 LNLKDYHRPSVE 263 >1KOB-A nrPDB Length = 387 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 68/269 (25%), Positives = 112/269 (41%), Gaps = 29/269 (10%) Query: 256 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL--KPGTMSPEAFLQE 313 QG D ++I E LG G FG V T RV + P + E Sbjct: 46 QGSVYDYYDILEE-------LGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVKNE 98 Query: 314 AQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQ 372 +M +L H KL+ L+ ++ + ++ E++S G L D + E K + ++++ Q Sbjct: 99 ISIMNQLHHPKLINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYK-MSEAEVINYMRQ 157 Query: 373 IASGMAYVERMNYVHRDLRAANILVGENLV--CKVADFGLARLIEDNEYTARQGAKFPIK 430 G+ ++ + VH D++ NI+ K+ DFGLA + +E A + Sbjct: 158 ACEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTAT--AE 215 Query: 431 WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC 490 + APE +D+W+ G+L L + G P+ G + E L V+R C E Sbjct: 216 FAAPEIVDREPVGFYTDMWAIGVLGYVLLS-GLSPFAGEDDLETLQNVKR-----CDWEF 269 Query: 491 PES--------LHDLMCQCWRKEPEERPT 511 E D + +KEP +R T Sbjct: 270 DEDAFSSVSPEAKDFIKNLLQKEPRKRLT 298 >4XBR-A nrPDB Length = 366 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 52/205 (25%), Positives = 99/205 (48%), Gaps = 10/205 (4%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLK-PGTMSPEAFLQEAQVMKKLRHE 323 PR L +K+G+G G V + T + + VA+K + E E +M+ +HE Sbjct: 92 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE 151 Query: 324 KLVQLYA--VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 +V++Y +V +E +++V E++ G+L D + T + Q+ + + ++ + Sbjct: 152 NVVEMYNSYLVGDE-LWVVMEFLEGGALTDIV---THTRMNEEQIAAVCLAVLQALSVLH 207 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 +HRD+++ +IL+ + K++DFG + E R+ W APE Sbjct: 208 AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVS-KEVPRRKSLVGTPYWMAPELISRLP 266 Query: 442 FTIKSDVWSFGILLTELTTKGRVPY 466 + + D+WS GI++ E+ G PY Sbjct: 267 YGPEVDIWSLGIMVIEM-VDGEPPY 290 >1FOT-A nrPDB Length = 318 Score = 72.8 bits (177), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 60/242 (24%), Positives = 108/242 (44%), Gaps = 18/242 (7%) Query: 276 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGTM----SPEAFLQEAQVMKKLRHEKLVQLYA 330 LG G FG V + R A+K LK + E E ++ + H +++++ Sbjct: 14 LGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWG 73 Query: 331 VVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD--MAAQIASGMAYVERMNYVH 387 + + I+++ +Y+ G L L+ K R P V AA++ + Y+ + ++ Sbjct: 74 TFQDAQQIFMIMDYIEGGELFSLLR----KSQRFPNPVAKFYAAEVCLALEYLHSKDIIY 129 Query: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 447 RDL+ NIL+ +N K+ DFG A+ + D YT + APE + D Sbjct: 130 RDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGTPDY----IAPEVVSTKPYNKSID 185 Query: 448 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPE 507 WSFGIL+ E+ G P+ + +++ + PP E + DL+ + ++ Sbjct: 186 WWSFGILIYEMLA-GYTPFYDSNTMKTYEKILNA-ELRFPPFFNEDVKDLLSRLITRDLS 243 Query: 508 ER 509 +R Sbjct: 244 QR 245 >4JDH-A nrPDB Length = 346 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 52/205 (25%), Positives = 99/205 (48%), Gaps = 10/205 (4%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLK-PGTMSPEAFLQEAQVMKKLRHE 323 PR L +K+G+G G V + T + + VA+K + E E +M+ +HE Sbjct: 72 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE 131 Query: 324 KLVQLYA--VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 +V++Y +V +E +++V E++ G+L D + T + Q+ + + ++ + Sbjct: 132 NVVEMYNSYLVGDE-LWVVMEFLEGGALTDIV---THTRMNEEQIAAVCLAVLQALSVLH 187 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 +HRD+++ +IL+ + K++DFG + E R+ W APE Sbjct: 188 AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQV-SKEVPRRKSLVGTPYWMAPELISRLP 246 Query: 442 FTIKSDVWSFGILLTELTTKGRVPY 466 + + D+WS GI++ E+ G PY Sbjct: 247 YGPEVDIWSLGIMVIEM-VDGEPPY 270 >4J52-A nrPDB Length = 293 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 63/256 (24%), Positives = 111/256 (43%), Gaps = 13/256 (5%) Query: 276 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTM-----SPEAFLQEAQVMKKLRHEKLVQLYA 330 LG+G F + + + T V + P ++ E E + + L H+ +V + Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 331 VVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 + +++V E + SLL+ K K L P+ QI G Y+ R +HRD Sbjct: 82 FFEDNDFVFVVLELCRRRSLLELHKRR--KALTEPEARYYLRQIVLGCQYLHRNRVIHRD 139 Query: 390 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 449 L+ N+ + E+L K+ DFGLA +E + + P + APE + + DVW Sbjct: 140 LKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTP-NYIAPEVLSKKGHSFEVDVW 198 Query: 450 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEER 509 S G ++ L G+ P+ +E ++++ P L+ + + +P R Sbjct: 199 SIGCIMYTLLV-GKPPFETSCLKETYLRIKKN-EYSIPKHINPVAASLIQKMLQTDPTAR 256 Query: 510 PTFEYLQAFLEDYFTS 525 PT L +++FTS Sbjct: 257 PTINELLN--DEFFTS 270 >5AR8-A nrPDB Length = 326 Score = 72.4 bits (176), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 70/252 (27%), Positives = 126/252 (50%), Gaps = 28/252 (11%) Query: 293 TRVAIKTLKPGTMSPEA----FLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKG 347 +VA+K L T ++ L+EA+++ K R ++ + + +E E + IVTEYM G Sbjct: 58 VQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNG 117 Query: 348 SLLDFLKGETGKY--LRLPQLVDMAAQIASGMAYVERMN--YVHRDLRAANILVGENLVC 403 SL + L +T +Y + P + +IA G+ Y+ M +H DL+ NIL+ Sbjct: 118 SLNELLHRKT-EYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHV 176 Query: 404 KVADFGLARLIEDNEYTARQGAKFP----IKWTAPEAALYG---RFTIKSDVWSFGILLT 456 K+ADFGL++ + +R P I + PE G R +IK D++S+ ++ Sbjct: 177 KIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITW 236 Query: 457 ELTTKGRVPYPGMVN-REVLDQVERGYR-----MPCPPECPE--SLHDLMCQCWRKEPEE 508 E+ ++ + P+ + N +++ V +G+R P + P + L+ W + P+E Sbjct: 237 EVLSRKQ-PFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDE 295 Query: 509 RPTFEYLQAFLE 520 RP+F L+ +E Sbjct: 296 RPSF--LKCLIE 305 >1S9I-A nrPDB Length = 354 Score = 72.4 bits (176), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 51/162 (31%), Positives = 85/162 (52%), Gaps = 12/162 (7%) Query: 310 FLQEAQVMKKLRHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQ--L 366 ++E QV+ + +V Y A S+ I I E+M GSL LK + R+P+ L Sbjct: 61 IIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLK----EAKRIPEEIL 116 Query: 367 VDMAAQIASGMAYV-ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGA 425 ++ + G+AY+ E+ +HRD++ +NILV K+ DFG++ + D+ + G Sbjct: 117 GKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGT 176 Query: 426 KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYP 467 + + APE ++++SD+WS G+ L EL GR P P Sbjct: 177 R---SYMAPERLQGTHYSVQSDIWSMGLSLVELAV-GRYPIP 214 >6FD3-A nrPDB Length = 300 Score = 72.0 bits (175), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 54/197 (27%), Positives = 96/197 (48%), Gaps = 12/197 (6%) Query: 275 KLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTM-SPEAFLQEAQVMKKLRHEKLVQ-LYAV 331 K+GQG G V+ T + VAIK + E + E VM++ ++ +V L + Sbjct: 29 KIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY 88 Query: 332 VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLR 391 + + +++V EY++ GSL D + T + Q+ + + + ++ +HRD++ Sbjct: 89 LVGDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIK 145 Query: 392 AANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 449 + NIL+G + K+ DFG I E ++ + G + W APE + K D+W Sbjct: 146 SDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPY---WMAPEVVTRKAYGPKVDIW 202 Query: 450 SFGILLTELTTKGRVPY 466 S GI+ E+ +G PY Sbjct: 203 SLGIMAIEM-VEGEPPY 218 >2Q0N-A nrPDB Length = 301 Score = 72.0 bits (175), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 52/205 (25%), Positives = 99/205 (48%), Gaps = 10/205 (4%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLK-PGTMSPEAFLQEAQVMKKLRHE 323 PR L +K+G+G G V + T + + VA+K + E E +M+ +HE Sbjct: 27 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE 86 Query: 324 KLVQLYA--VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 +V++Y +V +E +++V E++ G+L D + T + Q+ + + ++ + Sbjct: 87 NVVEMYNSYLVGDE-LWVVMEFLEGGALTDIV---THTRMNEEQIAAVCLAVLQALSVLH 142 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 +HRD+++ +IL+ + K++DFG + E R+ W APE Sbjct: 143 AQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVS-KEVPRRKSLVGTPYWMAPELISRLP 201 Query: 442 FTIKSDVWSFGILLTELTTKGRVPY 466 + + D+WS GI++ E+ G PY Sbjct: 202 YGPEVDIWSLGIMVIEM-VDGEPPY 225 >2JC6-A nrPDB Length = 334 Score = 71.6 bits (174), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 72/277 (25%), Positives = 125/277 (45%), Gaps = 19/277 (6%) Query: 251 SKPQTQGLAKDAWEIPRESLR--LEVK--LGQGCFGEVWMGTWNGTTRV-AIKTL-KPGT 304 S + G + +W+ E ++ E K LG G F EV + T ++ A+K + K Sbjct: 1 SMARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKAL 60 Query: 305 MSPEAFLQ-EAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLR 362 E+ ++ E V++K++HE +V L + S +Y+V + +S G L D + E G Y Sbjct: 61 KGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIV-EKGFYTE 119 Query: 363 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILV---GENLVCKVADFGLARLIEDNEY 419 + Q+ + Y+ RM VHRDL+ N+L E ++DFGL+++ E Sbjct: 120 -KDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM-EGKGD 177 Query: 420 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV- 478 P + APE ++ D WS G++ L G P+ + ++ +Q+ Sbjct: 178 VMSTACGTP-GYVAPEVLAQKPYSKAVDCWSIGVIAYILLC-GYPPFYDENDSKLFEQIL 235 Query: 479 --ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFE 513 E + P + +S D + K+P +R T E Sbjct: 236 KAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCE 272 >3HKO-A nrPDB Length = 345 Score = 71.6 bits (174), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 73/264 (27%), Positives = 114/264 (43%), Gaps = 60/264 (22%) Query: 271 RLEVKLGQGCFGEVWMGTWNGTTRV-AIKTL---KPGTMSP---EAFLQEAQVMKKLRHE 323 L+ +GQG +G V + N T + AIK + K ++P E E ++MKKL H Sbjct: 29 HLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKLHHP 88 Query: 324 KLVQLYAVVSEEP-IYIVTEYMSKGSLLD----FLKGETGK------------------- 359 + +LY V +E I +V E G LLD F+ TGK Sbjct: 89 NIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPECNEE 148 Query: 360 --------------YLRLPQLV-DMAAQIASGMAYVERMNYVHRDLRAANILVGEN--LV 402 +++ +L+ ++ QI S + Y+ HRD++ N L N Sbjct: 149 AINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTNKSFE 208 Query: 403 CKVADFGLAR---LIEDNEY---TARQGAKFPIKWTAPEA--ALYGRFTIKSDVWSFGIL 454 K+ DFGL++ + + EY T + G + + APE + K D WS G+L Sbjct: 209 IKLVDFGLSKEFYKLNNGEYYGMTTKAGTPY---FVAPEVLNTTNESYGPKCDAWSAGVL 265 Query: 455 LTELTTKGRVPYPGMVNREVLDQV 478 L L G VP+PG+ + + + QV Sbjct: 266 L-HLLLMGAVPFPGVNDADTISQV 288 >6E2O-A nrPDB Length = 295 Score = 71.6 bits (174), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 67/248 (27%), Positives = 117/248 (47%), Gaps = 17/248 (6%) Query: 274 VKLGQGCFGEVWMG-TWNGTTRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAV 331 V LG+G +G V+ G + R+AIK + + + + +E + K L+H+ +VQ Sbjct: 28 VVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGS 87 Query: 332 VSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDM-AAQIASGMAYVERMNYVHRD 389 SE I I E + GSL L+ + G Q + QI G+ Y+ VHRD Sbjct: 88 FSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRD 147 Query: 390 LRAANILVGE-NLVCKVADFGLA-RLIEDNEYTARQGAKFPIKWTAPEAALYG--RFTIK 445 ++ N+L+ + V K++DFG + RL N T + +++ APE G + Sbjct: 148 IKGDNVLINTYSGVLKISDFGTSKRLAGINPCT--ETFTGTLQYMAPEIIDKGPRGYGKA 205 Query: 446 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESL----HDLMCQC 501 +D+WS G + E+ T G+ P+ + + + + PE PES+ + +C Sbjct: 206 ADIWSLGCTIIEMAT-GKPPFYELGEPQA--AMFKVGMFKVHPEIPESMSAEAKAFILKC 262 Query: 502 WRKEPEER 509 + +P++R Sbjct: 263 FEPDPDKR 270 >5KKR-C nrPDB Length = 395 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 57/200 (28%), Positives = 98/200 (49%), Gaps = 15/200 (7%) Query: 275 KLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSP---EAFLQEAQVMKKLRHEKLVQLY-A 330 +LG G G V+ + + V + L + P ++E QV+ + +V Y A Sbjct: 75 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 134 Query: 331 VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQ--LVDMAAQIASGMAYV-ERMNYVH 387 S+ I I E+M GSL LK K R+P+ L ++ + G+ Y+ E+ +H Sbjct: 135 FYSDGEISICMEHMDGGSLDQVLK----KAGRIPEQILGKVSIAVIKGLTYLREKHKIMH 190 Query: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 447 RD++ +NILV K+ DFG++ + D+ + G + + +PE ++++SD Sbjct: 191 RDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQGTHYSVQSD 247 Query: 448 VWSFGILLTELTTKGRVPYP 467 +WS G+ L E+ GR P P Sbjct: 248 IWSMGLSLVEMAV-GRYPIP 266 >3Q53-A nrPDB Length = 306 Score = 71.2 bits (173), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 53/197 (26%), Positives = 96/197 (48%), Gaps = 12/197 (6%) Query: 275 KLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTM-SPEAFLQEAQVMKKLRHEKLVQ-LYAV 331 K+GQG G V+ T + VAI+ + E + E VM++ ++ +V L + Sbjct: 28 KIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY 87 Query: 332 VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLR 391 + + +++V EY++ GSL D + T + Q+ + + + ++ +HRD++ Sbjct: 88 LVGDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIK 144 Query: 392 AANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 449 + NIL+G + K+ DFG I E ++ + G + W APE + K D+W Sbjct: 145 SDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPY---WMAPEVVTRKAYGPKVDIW 201 Query: 450 SFGILLTELTTKGRVPY 466 S GI+ E+ +G PY Sbjct: 202 SLGIMAIEM-IEGEPPY 217 >3EQC-A nrPDB Length = 360 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 57/200 (28%), Positives = 98/200 (49%), Gaps = 15/200 (7%) Query: 275 KLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSP---EAFLQEAQVMKKLRHEKLVQLY-A 330 +LG G G V+ + + V + L + P ++E QV+ + +V Y A Sbjct: 40 ELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA 99 Query: 331 VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQ--LVDMAAQIASGMAYV-ERMNYVH 387 S+ I I E+M GSL LK K R+P+ L ++ + G+ Y+ E+ +H Sbjct: 100 FYSDGEISICMEHMDGGSLDQVLK----KAGRIPEQILGKVSIAVIKGLTYLREKHKIMH 155 Query: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 447 RD++ +NILV K+ DFG++ + D+ + G + + +PE ++++SD Sbjct: 156 RDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTR---SYMSPERLQGTHYSVQSD 212 Query: 448 VWSFGILLTELTTKGRVPYP 467 +WS G+ L E+ GR P P Sbjct: 213 IWSMGLSLVEMAV-GRYPIP 231 >3ORZ-A nrPDB Length = 316 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 56/205 (27%), Positives = 90/205 (43%), Gaps = 21/205 (10%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEA----FLQEAQVMKKLRH 322 E + LG+G F V + T+R AIK L+ + E +E VM +L H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 323 EKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD------MAAQIAS 375 V+LY +E +Y Y G LL KY+R D A+I S Sbjct: 97 PFFVKLYFCFQDDEKLYFGLSYAKNGELL--------KYIRKIGSFDETCTRFYTAEIVS 148 Query: 376 GMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKF-PIKWTAP 434 + Y+ +HRDL+ NIL+ E++ ++ DFG A+++ AR + ++ +P Sbjct: 149 ALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSP 208 Query: 435 EAALYGRFTIKSDVWSFGILLTELT 459 E SD+W+ G ++ +L Sbjct: 209 ELLTEKSACKSSDLWALGCIIYQLV 233 >5Z33-A nrPDB Length = 425 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 65/220 (29%), Positives = 101/220 (45%), Gaps = 21/220 (9%) Query: 275 KLGQGCFGEVWMGTWNGTTR-VAIKTLK---PGTMSPEAFLQEAQVMKKLR-HEKLVQLY 329 +LGQG +G V N T+ VAIK + + + L+E ++++ R H + LY Sbjct: 38 ELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHFRGHRNITCLY 97 Query: 330 AVVSEEP-----IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN 384 + P Y+ E M + L ++ +G+ L QI G+ Y+ N Sbjct: 98 DMDIPRPDNFNETYLYEELM-ECDLAAIIR--SGQPLTDAHFQSFIYQILCGLKYIHSAN 154 Query: 385 YVHRDLRAANILVGENLVCKVADFGLAR--LIEDNEYTARQGAKFPIKW-TAPEAAL-YG 440 +HRDL+ N+LV + K+ DFGLAR ++ E +W APE L + Sbjct: 155 VLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWYRAPEIMLSFQ 214 Query: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480 +T DVWS G +L EL GR P R+ +DQ+ + Sbjct: 215 SYTKAIDVWSVGCILAELLG-GR---PFFKGRDYVDQLNQ 250 >4UZD-A nrPDB Length = 287 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 58/250 (23%), Positives = 104/250 (41%), Gaps = 27/250 (10%) Query: 276 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSP----EAFLQEAQVMKKLRHEKLVQLYA 330 LG+G FG V++ + + A+K L + +E ++ LRH +++LY Sbjct: 16 LGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYG 75 Query: 331 VVSEEP-IYIVTEYMSKGS-------LLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 + +Y++ EY G+ L F + T Y+ ++A+ ++Y Sbjct: 76 YFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYI---------TELANALSYCHS 126 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 +HRD++ N+L+G K+ADFG + + T G + + PE Sbjct: 127 KRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGT---LDYLPPEMIEGRMH 183 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCW 502 K D+WS G+L E G+ P+ +E ++ R P E DL+ + Sbjct: 184 DEKVDLWSLGVLCYEFLV-GKPPFEANTYQETYKRISR-VEFTFPDFVTEGARDLISRLL 241 Query: 503 RKEPEERPTF 512 + P +RP Sbjct: 242 KHNPSQRPML 251 >4PWN-A nrPDB Length = 274 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 75/273 (27%), Positives = 131/273 (47%), Gaps = 32/273 (11%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSP---EAFLQEAQVMKKLRHEKL 325 L+ ++++G+G F V+ G TT VA L+ ++ + F +EA+++K L+H + Sbjct: 12 LKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHPNI 71 Query: 326 VQLY-----AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 V+ Y V ++ I +VTE M+ G+L +LK K +++ L QI G+ ++ Sbjct: 72 VRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLK--RFKVMKIKVLRSWCRQILKGLQFL 129 Query: 381 ERMN--YVHRDLRAANILV-GENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 437 +HRDL+ NI + G K+ D GLA L E A+ P ++ APE Sbjct: 130 HTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL-EKRASFAKSVIGTP-EFMAPE-- 185 Query: 438 LY-GRFTIKSDVWSFGILLTELTTKGRVPYPGMVN-REVLDQVERG-----YRMPCPPEC 490 +Y ++ DV++FG+ + E+ T PY N ++ +V G + PE Sbjct: 186 MYEEKYDESVDVYAFGMCMLEMAT-SEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEV 244 Query: 491 PESLHDLMCQCWRKEPEERPTFEYL--QAFLED 521 E + C R+ +ER + + L AF ++ Sbjct: 245 KEIIEG----CIRQNKDERYSIKDLLNHAFFQE 273 >5O2C-A nrPDB Length = 380 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 60/215 (27%), Positives = 104/215 (48%), Gaps = 21/215 (9%) Query: 270 LRLEVKLGQGCFGEVWMG----TWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKL 325 L+ +++LG+G F V+ G TW ++ K + F +EA+++K L+H + Sbjct: 27 LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNI 86 Query: 326 VQLY-----AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 V+ Y + ++ I +VTE M+ G+L +LK K ++ L QI G+ ++ Sbjct: 87 VRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK--RFKVMKPKVLRSWCRQILKGLQFL 144 Query: 381 ERMN--YVHRDLRAANILV-GENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 437 +HRDL+ NI + G K+ D GLA L+ + + G ++ APE Sbjct: 145 HTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTP---EFMAPE-- 199 Query: 438 LYGRFTIKS-DVWSFGILLTELTTKGRVPYPGMVN 471 +Y +S DV++FG+ + E+ T PY N Sbjct: 200 MYEEHYDESVDVYAFGMCMLEMAT-SEYPYSECQN 233 >3TKU-A nrPDB Length = 433 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 65/231 (28%), Positives = 107/231 (46%), Gaps = 23/231 (9%) Query: 251 SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEA 309 +KP TQ L K+ ++ RE + +G+G FGEV + T R+ A+K L M A Sbjct: 75 AKPFTQ-LVKEM-QLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRA 132 Query: 310 ----FLQEAQVMKKLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP 364 F +E V+ + + L YA E +Y+V +Y G LL L K LP Sbjct: 133 ETACFREERDVLVNGDCQWITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDK---LP 189 Query: 365 QLVDMA----AQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT 420 + DMA ++ + + +++YVHRD++ N+L+ N ++ADFG + D+ Sbjct: 190 E--DMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTV 247 Query: 421 ARQGAKFPIKWTAPEAAL-----YGRFTIKSDVWSFGILLTELTTKGRVPY 466 A + +PE G++ + D WS G+ + E+ G P+ Sbjct: 248 QSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLY-GETPF 297 >4CZT-A nrPDB Length = 464 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 69/249 (27%), Positives = 110/249 (44%), Gaps = 20/249 (8%) Query: 276 LGQGCFGEVWMG--TWNGTTRVAIKTL-KPGTMSPEAFLQ---EAQVMKKLRHEKLVQLY 329 LG+G F +V NG VAIK + K + + Q E MK ++H +++++ Sbjct: 19 LGEGTFAKVKFARNVENGDN-VAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPNVIRMF 77 Query: 330 AVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 V+ S+ IY V E+++ G L D K + L+ + Q+ + + Y HR Sbjct: 78 EVMASKTKIYFVLEFVTGGELFD--KISSNGRLKEDEARKYFQQLINAVDYCHSRGVYHR 135 Query: 389 DLRAANILVGENLVCKVADFGLARL----IEDNEYTARQGAKFPIKWTAPEAA-LYGRFT 443 DL+ N+L+ N KV+DFGL+ L ED G + APE G Sbjct: 136 DLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTP---NYVAPEVINNKGYDG 192 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503 K+D+WS G++L L G +P+ + ++ + CPP S L+ + Sbjct: 193 AKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-EFTCPPWFSASAKKLIKRILD 250 Query: 504 KEPEERPTF 512 P R TF Sbjct: 251 PNPATRITF 259 >4X3F-A nrPDB Length = 337 Score = 70.1 bits (170), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 93/209 (44%), Gaps = 14/209 (6%) Query: 271 RLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQ----EAQVMKKLRHEKL 325 RL+ + G G+VW N RVA+K LK S F++ EA+ L H + Sbjct: 15 RLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGI 74 Query: 326 VQLYAVVSEE------PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 ++ + Y+V E ++ L LK TG+ L L +DM Q + Sbjct: 75 ASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLK-RTGR-LSLRHALDMLEQTGRALQI 132 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 VHRD++ NIL+ K+ DFG+A+ ++ T ++ APE AL Sbjct: 133 AHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 192 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPG 468 + SDV+S G++ E + G+ P+ G Sbjct: 193 HDASPASDVYSLGVVGYEAVS-GKRPFAG 220 >6DTL-A nrPDB Length = 364 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 54/205 (26%), Positives = 96/205 (46%), Gaps = 19/205 (9%) Query: 276 LGQGCFGEVWMGTWNGTTR-VAIKTLK---PGTMSPEAFLQEAQVMKKLRHEKLVQLYAV 331 +G+G +G V + T VAIK + + + L+E ++++ + HE +V + + Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRDI 97 Query: 332 V------SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 + + +YI E M L ++ + + L QI G+ Y+ N Sbjct: 98 IPPPLRNAFNDVYIAYELMDT-DLHQIIR--SNQALSEEHCQYFLYQILRGLKYIHSANV 154 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKW-TAPEAALYGR-FT 443 +HRDL+ +N+L+ N K+ DFGLAR+ ++++ +W APE L +T Sbjct: 155 LHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVT---RWYRAPELLLNSSDYT 211 Query: 444 IKSDVWSFGILLTELTTKGRVPYPG 468 DVWS G + EL + + +PG Sbjct: 212 AAIDVWSVGCIFMELMDRKPL-FPG 235 >4OW8-A nrPDB Length = 283 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 93/209 (44%), Gaps = 14/209 (6%) Query: 271 RLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQ----EAQVMKKLRHEKL 325 RL+ + G G+VW N RVA+K LK S F++ EA+ L H + Sbjct: 14 RLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGI 73 Query: 326 VQLYAVVSEE------PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 ++ + Y+V E ++ L LK TG+ L L +DM Q + Sbjct: 74 ASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLK-RTGR-LSLRHALDMLEQTGRALQI 131 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 VHRD++ NIL+ K+ DFG+A+ ++ T ++ APE AL Sbjct: 132 AHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 191 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPG 468 + SDV+S G++ E + G+ P+ G Sbjct: 192 HDASPASDVYSLGVVGYEAVS-GKRPFAG 219 >3GUB-A nrPDB Length = 295 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 49/180 (27%), Positives = 91/180 (50%), Gaps = 12/180 (6%) Query: 305 MSPEAFLQEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRL 363 +S E +E ++K+++H ++ L+ V ++ + ++ E ++ G L DFL + L Sbjct: 56 VSREDIEREVSILKEIQHPNVITLHEVYENKTDVILIGELVAGGELFDFLAEKES--LTE 113 Query: 364 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLV----CKVADFGLARLIE-DNE 418 + + QI +G+ Y+ + H DL+ NI++ + V K+ DFGLA I+ NE Sbjct: 114 EEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNE 173 Query: 419 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 + G ++ APE Y +++D+WS G+ +T + G P+ G +E L V Sbjct: 174 FKNIFGTP---EFVAPEIVNYEPLGLEADMWSIGV-ITYILLSGASPFLGDTKQETLANV 229 >5O2B-A nrPDB Length = 285 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 60/215 (27%), Positives = 104/215 (48%), Gaps = 21/215 (9%) Query: 270 LRLEVKLGQGCFGEVWMG----TWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKL 325 L+ +++LG+G F V+ G TW ++ K + F +EA+++K L+H + Sbjct: 18 LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNI 77 Query: 326 VQLY-----AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 V+ Y + ++ I +VTE M+ G+L +LK K ++ L QI G+ ++ Sbjct: 78 VRFYDSWESILKGKKCIVLVTELMTSGTLKTYLK--RFKVMKPKVLRSWCRQILKGLQFL 135 Query: 381 ERMN--YVHRDLRAANILV-GENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 437 +HRDL+ NI + G K+ D GLA L+ + + G ++ APE Sbjct: 136 HTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTP---EFMAPE-- 190 Query: 438 LYGRFTIKS-DVWSFGILLTELTTKGRVPYPGMVN 471 +Y +S DV++FG+ + E+ T PY N Sbjct: 191 MYEEHYDESVDVYAFGMCMLEMAT-SEYPYSECQN 224 >3DB8-A nrPDB Length = 317 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 61/256 (23%), Positives = 109/256 (42%), Gaps = 13/256 (5%) Query: 276 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTM-----SPEAFLQEAQVMKKLRHEKLVQLYA 330 LG+G F + + T T V + P +M E E + K L + +V + Sbjct: 50 LGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNPHVVGFHG 109 Query: 331 VVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 ++ +Y+V E + SLL+ K K + P+ Q G+ Y+ +HRD Sbjct: 110 FFEDDDFVYVVLEICRRRSLLELHKRR--KAVTEPEARYFMRQTIQGVQYLHNNRVIHRD 167 Query: 390 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 449 L+ N+ + +++ K+ DFGLA IE + + P + APE + + D+W Sbjct: 168 LKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTP-NYIAPEVLCKKGHSFEVDIW 226 Query: 450 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEER 509 S G +L L G+ P+ +E ++++ P L+ + +P R Sbjct: 227 SLGCILYTLLV-GKPPFETSCLKETYIRIKKN-EYSVPRHINPVASALIRRMLHADPTLR 284 Query: 510 PTFEYLQAFLEDYFTS 525 P+ L +++FTS Sbjct: 285 PSVAEL--LTDEFFTS 298 >2I6L-A nrPDB Length = 320 Score = 68.6 bits (166), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 61/214 (28%), Positives = 103/214 (48%), Gaps = 26/214 (12%) Query: 276 LGQGCFGEVWMGTWNGTT-RVAIKTLK-PGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS 333 LG G G V+ N RVAIK + S + L+E +++++L H+ +V+++ ++ Sbjct: 19 LGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILG 78 Query: 334 E---------------EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378 +YIV EYM + L + L E G L + M Q+ G+ Sbjct: 79 PSGSQLTDDVGSLTELNSVYIVQEYM-ETDLANVL--EQGPLLEEHARLFMY-QLLRGLK 134 Query: 379 YVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLIEDN-EYTARQGAKFPIKW-TAPE 435 Y+ N +HRDL+ AN+ + E+LV K+ DFGLAR+++ + + KW +P Sbjct: 135 YIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPR 194 Query: 436 AALY-GRFTIKSDVWSFGILLTELTTKGRVPYPG 468 L +T D+W+ G + E+ T G+ + G Sbjct: 195 LLLSPNNYTKAIDMWAAGCIFAEMLT-GKTLFAG 227 >4C0T-A nrPDB Length = 974 Score = 68.6 bits (166), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 66/260 (25%), Positives = 117/260 (45%), Gaps = 25/260 (9%) Query: 275 KLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQ----EAQVMKKLRHE-KLVQL 328 +LG+G + V + T T + A+K L + E ++ E + +L + ++ L Sbjct: 273 ELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHALNRLSNRLGVISL 332 Query: 329 YAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQ--LVDMAAQIASGMAYVERMNY 385 Y + + +Y V +Y S G LL +K +Y L + AQI + Y+ Sbjct: 333 YFTFQDKDSLYFVLDYASNGELLTLIK----RYNTLNEECTRHFGAQILDAIKYMHDNGV 388 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLI-----EDNEYTARQGAKFPI---KWTAPEAA 437 +HRDL+ NIL+ + + ++ DFG ARL+ E EY AK + ++ +PE Sbjct: 389 IHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGTAEYVSPE-L 447 Query: 438 LYGRFTIK-SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 L ++ K DVW+FG ++ ++ G+ P+ N + Q + P + D Sbjct: 448 LENKYCGKPGDVWAFGCIIYQMIA-GKPPFKA-TNEYLTFQKITKLQFAFSAGFPTIIRD 505 Query: 497 LMCQCWRKEPEERPTFEYLQ 516 L+ + +P R T +Q Sbjct: 506 LIKKILVLQPSRRATIPEIQ 525 >2WTK-C nrPDB Length = 305 Score = 68.6 bits (166), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 59/226 (26%), Positives = 101/226 (44%), Gaps = 17/226 (7%) Query: 312 QEAQVMKKLRHEKLVQLYAVVSEE---PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD 368 +E Q++++LRH+ ++QL V+ E +Y+V EY G + + L K + Q Sbjct: 55 KEIQLLRRLRHKNVIQLVDVLYNEEKQKMYMVMEYCVCG-MQEMLDSVPEKRFPVCQAHG 113 Query: 369 MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE----DNEYTARQG 424 Q+ G+ Y+ VH+D++ N+L+ K++ G+A + D+ QG Sbjct: 114 YFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQG 173 Query: 425 AKFPIKWTAPEAA--LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY 482 + + PE A L K D+WS G+ L +TT G P+ G ++ + + +G Sbjct: 174 SP---AFQPPEIANGLDTFSGFKVDIWSAGVTLYNITT-GLYPFEGDNIYKLFENIGKG- 228 Query: 483 RMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEP 528 P +C L DL+ EP +R F Q +F P Sbjct: 229 SYAIPGDCGPPLSDLLKGMLEYEPAKR--FSIRQIRQHSWFRKKHP 272 >2UV2-A nrPDB Length = 325 Score = 68.6 bits (166), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 70/265 (26%), Positives = 115/265 (43%), Gaps = 26/265 (9%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---FLQEAQV 316 +D WEI E LG G FG+V+ N T V T S E ++ E + Sbjct: 36 EDFWEIIGE-------LGDGAFGKVYKAQ-NKETSVLAAAKVIDTKSEEELEDYMVEIDI 87 Query: 317 MKKLRHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIAS 375 + H +V+L A E ++I+ E+ + G++ D + E + L Q+ + Q Sbjct: 88 LASCDHPNIVKLLDAFYYENNLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTLD 146 Query: 376 GMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKF--PIKWTA 433 + Y+ +HRDL+A NIL + K+ADFG++ N T ++ F W A Sbjct: 147 ALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSA---KNTRTIQRRDSFIGTPYWMA 203 Query: 434 PEAALYGR-----FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY--RMPC 486 PE + + K+DVWS GI L E+ + P+ + VL ++ + + Sbjct: 204 PEVVMCETSKDRPYDYKADVWSLGITLIEM-AEIEPPHHELNPMRVLLKIAKSEPPTLAQ 262 Query: 487 PPECPESLHDLMCQCWRKEPEERPT 511 P + D + +C K + R T Sbjct: 263 PSRWSSNFKDFLKKCLEKNVDARWT 287 >4L42-A nrPDB Length = 346 Score = 68.6 bits (166), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 63/257 (24%), Positives = 119/257 (46%), Gaps = 17/257 (6%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMG---TWNGTTRV-AIKTLKPGTMSPEA-----FLQEA 314 +I E L LG+G +G+V+ T T ++ A+K LK + A E Sbjct: 14 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER 73 Query: 315 QVMKKLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373 ++++++H +V L YA + +Y++ EY+S G L F++ E A+I Sbjct: 74 NILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL--FMQLEREGIFMEDTACFYLAEI 131 Query: 374 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR-LIEDNEYTARQGAKFPIKWT 432 + + ++ + ++RDL+ NI++ K+ DFGL + I D T I++ Sbjct: 132 SMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGT--IEYM 189 Query: 433 APEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE 492 APE + D WS G L+ ++ T G P+ G ++ +D++ + ++ PP + Sbjct: 190 APEILMRSGHNRAVDWWSLGALMYDMLT-GAPPFTGENRKKTIDKILK-CKLNLPPYLTQ 247 Query: 493 SLHDLMCQCWRKEPEER 509 DL+ + ++ R Sbjct: 248 EARDLLKKLLKRNAASR 264 >6B2Q-A nrPDB Length = 317 Score = 68.6 bits (166), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 59/209 (28%), Positives = 92/209 (44%), Gaps = 14/209 (6%) Query: 271 RLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQ----EAQVMKKLRHEKL 325 RL+ + G G+VW N RVA+K LK S F++ EA+ L H + Sbjct: 35 RLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNHPGI 94 Query: 326 VQLYAVVSEE------PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 ++ + Y+V E ++ L LK TG+ L L +DM Q + Sbjct: 95 ASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLK-RTGR-LSLRHALDMLEQTGRALQI 152 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 VHRD++ NIL+ K+ DFG+A+ ++ T ++ APE AL Sbjct: 153 AHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALG 212 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPG 468 + SDV+S G++ E G+ P+ G Sbjct: 213 HDASPASDVYSLGVVGYE-AVSGKRPFAG 240 >1G3N-A nrPDB Length = 326 Score = 68.2 bits (165), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 54/198 (27%), Positives = 95/198 (47%), Gaps = 17/198 (8%) Query: 275 KLGQGCFGEVWMG--TWNGTTRVAIKTLKPGTMS---PEAFLQEAQVMKKLR---HEKLV 326 ++G+G +G+V+ NG VA+K ++ T P + ++E V++ L H +V Sbjct: 18 EIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVV 77 Query: 327 QLYAVVS------EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 +L+ V + E + +V E++ + L +L + + DM Q+ G+ ++ Sbjct: 78 RLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFL 136 Query: 381 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 440 VHRDL+ NILV + K+ADFGLAR+ + A + + APE L Sbjct: 137 HSHRVVHRDLKPQNILVTSSGQIKLADFGLARIY--SFQMALTSVVVTLWYRAPEVLLQS 194 Query: 441 RFTIKSDVWSFGILLTEL 458 + D+WS G + E+ Sbjct: 195 SYATPVDLWSVGCIFAEM 212 >4AW2-A nrPDB Length = 437 Score = 68.2 bits (165), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 65/232 (28%), Positives = 107/232 (46%), Gaps = 25/232 (10%) Query: 251 SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEA 309 +KP T + + + RE + +G+G FGEV + +V A+K L M A Sbjct: 59 AKPFTSKVKQ--MRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRA 116 Query: 310 ----FLQEAQVMKKLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP 364 F +E V+ + + L YA + +Y+V +Y G LL L RLP Sbjct: 117 ETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFED---RLP 173 Query: 365 QLVDMA----AQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFG-LARLIEDNEY 419 + +MA A++ + V +++YVHRD++ NIL+ N ++ADFG +L+ED Sbjct: 174 E--EMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTV 231 Query: 420 TARQGAKFPIKWTAPEAAL-----YGRFTIKSDVWSFGILLTELTTKGRVPY 466 + P + +PE GR+ + D WS G+ + E+ G P+ Sbjct: 232 QSSVAVGTP-DYISPEILQAMEGGKGRYGPECDWWSLGVCMYEMLY-GETPF 281 >4BGQ-A nrPDB Length = 304 Score = 68.2 bits (165), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 56/199 (28%), Positives = 99/199 (49%), Gaps = 10/199 (5%) Query: 276 LGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEA---FLQEAQVMKKLRHEKLVQLY-A 330 +G+G +G V T VAIK K + E L+E ++++ L+ E +V+L A Sbjct: 20 VGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEA 79 Query: 331 VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDL 390 +Y+V EY+ K ++L+ L+ E + ++ Q+ + + + + VHRD+ Sbjct: 80 FRRRGKLYLVFEYVEK-NMLELLE-EMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDI 137 Query: 391 RAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKW-TAPEAALYGRFTIKSDVW 449 + N+L+ N V K+ DFG AR + + A + +W +PE L + D+W Sbjct: 138 KPENLLISHNDVLKLCDFGFARNLSEGN-NANYDEEVATRWYRSPELLLGAPYGKSVDMW 196 Query: 450 SFGILLTELTTKGRVPYPG 468 S G +L EL+ G+ +PG Sbjct: 197 SVGCILGELSD-GQPLFPG 214 >3LM0-A nrPDB Length = 327 Score = 68.2 bits (165), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 55/196 (28%), Positives = 88/196 (44%), Gaps = 11/196 (5%) Query: 324 KLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 L ++Y SE I ++ EY + G + E + + ++ + QI G+ Y+ + Sbjct: 93 NLHEVYENTSE--IILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQN 150 Query: 384 NYVHRDLRAANILVGENL---VCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 440 N VH DL+ NIL+ K+ DFG++R I + R+ P ++ APE Y Sbjct: 151 NIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKI-GHACELREIMGTP-EYLAPEILNYD 208 Query: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREV---LDQVERGYRMPCPPECPESLHDL 497 T +D+W+ GI+ L T P+ G N+E + QV Y + D Sbjct: 209 PITTATDMWNIGIIAYMLLTHTS-PFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDF 267 Query: 498 MCQCWRKEPEERPTFE 513 + K PE+RPT E Sbjct: 268 IQSLLVKNPEKRPTAE 283 >3RP9-A nrPDB Length = 458 Score = 68.2 bits (165), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 71/276 (25%), Positives = 109/276 (39%), Gaps = 64/276 (23%) Query: 263 WEIPRESLRLEVK--LGQGCFGEVWMGTWNGTTRV-AIKTLK---PGTMSPEAFLQEAQV 316 W+IP R E++ +G G +G V RV AIK + + + L+E + Sbjct: 49 WQIPD---RYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAI 105 Query: 317 MKKLRHEKLVQLYAVVSEEPI------YIVTEYMSKGSLLDFLK-GETGKYLRLPQLVDM 369 + +L H+ +V++ +V + + Y+V E DF K T YL + + Sbjct: 106 LNRLNHDHVVKVLDIVIPKDVEKFDELYVVLEIADS----DFKKLFRTPVYLTELHIKTL 161 Query: 370 AAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 429 + G+ YV +HRDL+ AN LV ++ KV DFGLAR + +Y ++ PI Sbjct: 162 LYNLLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTV---DYPENGNSQLPI 218 Query: 430 K-----------------------------WTAPEAALYG-RFTIKSDVWSFGILLTELT 459 + APE L +T DVWS G + EL Sbjct: 219 SPREDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELL 278 Query: 460 TKGRVPYPGMVNREVLDQVERGYRMP---CPPECPE 492 M+ V +RG P C P P+ Sbjct: 279 --------NMIKENVAYHADRGPLFPGSSCFPLSPD 306 >1UA2-A nrPDB Length = 346 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 63/219 (28%), Positives = 106/219 (48%), Gaps = 22/219 (10%) Query: 276 LGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP------EAFLQEAQVMKKLRHEKLVQL 328 LG+G F V+ T + VAIK +K G S L+E +++++L H ++ L Sbjct: 18 LGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGL 77 Query: 329 Y-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 A + I +V ++M L+ + + L + G+ Y+ + +H Sbjct: 78 LDAFGHKSNISLVFDFMETD--LEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILH 135 Query: 388 RDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYGR-FTI 444 RDL+ N+L+ EN V K+ADFGLA+ + YT + ++ + APE R + + Sbjct: 136 RDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRW---YRAPELLFGARMYGV 192 Query: 445 KSDVWSFGILLTELTTKGRVPY-PGMVNREVLDQVERGY 482 D+W+ G +L EL RVP+ PG + LDQ+ R + Sbjct: 193 GVDMWAVGCILAELLL--RVPFLPGDSD---LDQLTRIF 226 >4RLP-A nrPDB Length = 288 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 63/257 (24%), Positives = 119/257 (46%), Gaps = 17/257 (6%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMG---TWNGTTRV-AIKTLKPGTMSPEA-----FLQEA 314 +I E L LG+G +G+V+ T T ++ A+K LK + A E Sbjct: 1 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER 60 Query: 315 QVMKKLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373 ++++++H +V L YA + +Y++ EY+S G L F++ E A+I Sbjct: 61 NILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL--FMQLEREGIFMEDTACFYLAEI 118 Query: 374 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR-LIEDNEYTARQGAKFPIKWT 432 + + ++ + ++RDL+ NI++ K+ DFGL + I D T I++ Sbjct: 119 SMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCG--TIEYM 176 Query: 433 APEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE 492 APE + D WS G L+ ++ T G P+ G ++ +D++ + ++ PP + Sbjct: 177 APEILMRSGHNRAVDWWSLGALMYDMLT-GAPPFTGENRKKTIDKILK-CKLNLPPYLTQ 234 Query: 493 SLHDLMCQCWRKEPEER 509 DL+ + ++ R Sbjct: 235 EARDLLKKLLKRNAASR 251 >4TNB-A nrPDB Length = 590 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 57/223 (25%), Positives = 104/223 (46%), Gaps = 11/223 (4%) Query: 265 IPRESLRLEVKLGQGCFGEVW------MGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 318 + + + R LG+G FGEV G R+ K +K A L E Q+++ Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMA-LNEKQILE 239 Query: 319 KLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 K+ + +V L YA +++ + +V M+ G L + + + AA+I G+ Sbjct: 240 KVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGL 299 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 437 + N V+RDL+ NIL+ + +++D GLA I + + +G + + APE Sbjct: 300 EDLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLI--RGRVGTVGYMAPEVL 357 Query: 438 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480 R+ + D W G L+ E+ +G+ P+ G + ++V+R Sbjct: 358 NNQRYGLSPDYWGLGCLIYEM-IEGQSPFRGRKEKVKREEVDR 399 >2W4O-A nrPDB Length = 349 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 78/291 (26%), Positives = 134/291 (46%), Gaps = 26/291 (8%) Query: 244 LTTVCPTSKPQTQGLAKDAW------EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VA 296 +++V ++ P T L D W + + +E +LG+G V+ GT + A Sbjct: 23 MSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYA 82 Query: 297 IKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEP--IYIVTEYMSKGSLLDFLK 354 +K LK T+ + E V+ +L H +++L + E P I +V E ++ G L D + Sbjct: 83 LKVLKK-TVDKKIVRTEIGVLLRLSHPNIIKLKEIF-ETPTEISLVLELVTGGELFDRIV 140 Query: 355 GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLA 411 E G Y D QI +AY+ VHRDL+ N+L + K+ADFGL+ Sbjct: 141 -EKGYYSE-RDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLS 198 Query: 412 RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPY----- 466 +++E ++ + P + APE + + D+WS GI +T + G P+ Sbjct: 199 KIVE-HQVLMKTVCGTP-GYCAPEILRGCAYGPEVDMWSVGI-ITYILLCGFEPFYDERG 255 Query: 467 PGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEER-PTFEYLQ 516 + R +L+ E + P E + DL+ + +P++R TF+ LQ Sbjct: 256 DQFMFRRILN-CEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQ 305 >1VZO-A nrPDB Length = 355 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 71/274 (25%), Positives = 126/274 (45%), Gaps = 23/274 (8%) Query: 254 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMG---TWNGTTRV-AIKTLKPGTM---- 305 +T L A ++ E+ L LG G +G+V++ + + T ++ A+K LK T+ Sbjct: 40 RTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKA 99 Query: 306 -SPEAFLQEAQVMKKLRHEK-LVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLR 362 + E E QV++ +R LV L YA +E ++++ +Y++ G L L Sbjct: 100 KTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEH 159 Query: 363 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTAR 422 Q+ +I + ++ ++ ++RD++ NIL+ N + DFGL++ +E Sbjct: 160 EVQI--YVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERA 217 Query: 423 QGAKFPIKWTAPEAALYGR--FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480 I++ AP+ G D WS G+L+ EL T G P+ V+ E Q E Sbjct: 218 YDFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLT-GASPFT--VDGEKNSQAEI 274 Query: 481 GYRM-----PCPPECPESLHDLMCQCWRKEPEER 509 R+ P P E DL+ + K+P++R Sbjct: 275 SRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKR 308 >4L68-A nrPDB Length = 340 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 51/174 (29%), Positives = 87/174 (50%), Gaps = 10/174 (5%) Query: 295 VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL--YAVVSEEPIYIVTEYMSKGSLLDF 352 +A+K L + F E + +LRH L L + VV EE ++V +YMS G+L Sbjct: 67 LAVKHLSTCKLGEREFRYEMNQLWELRHSNLAPLLGFCVVEEEK-FLVYKYMSNGTLHSL 125 Query: 353 LKGETGKYLRLPQLVDMAAQIASGMAYVE---RMNYVHRDLRAANILVGENLVCKVADFG 409 L G+ L + A G+A++ R +H+++ ++ IL+ E+ ++ D G Sbjct: 126 LDSNRGE-LDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSG 184 Query: 410 LARLI---EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTT 460 LARL+ ++NE + G + APE + ++K DV+ G++L EL T Sbjct: 185 LARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLASLKGDVYGLGVVLLELAT 238 >4WB7-A nrPDB Length = 405 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 56/229 (24%), Positives = 104/229 (45%), Gaps = 14/229 (6%) Query: 276 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSP----EAFLQEAQVMKKLRHEKLVQL-Y 329 LG G FG V + T A+K L + E L E ++++ + LV+L + Sbjct: 104 LGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEF 163 Query: 330 AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 + +Y+V EY+ G + L+ G++ P AAQI Y+ ++ ++RD Sbjct: 164 SFKDNSNLYMVMEYVPGGEMFSHLR-RIGRFSE-PHARFYAAQIVLTFEYLHSLDLIYRD 221 Query: 390 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 449 L+ N+L+ + +V DFG A+ ++ +T ++ APE L + D W Sbjct: 222 LKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEY----LAPEIILSKGYNKAVDWW 277 Query: 450 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM 498 + G+L+ E+ G P+ ++ +++ G ++ P L DL+ Sbjct: 278 ALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLL 324 >4IC8-A nrPDB Length = 442 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 97/213 (45%), Gaps = 29/213 (13%) Query: 276 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAF---------LQEAQVMKKLRHEKL 325 +G G +G V T +VAIK + P AF L+E +++K +H+ + Sbjct: 63 IGNGAYGVVSSARRRLTGQQVAIKKI------PNAFDVVTNAKRTLRELKILKHFKHDNI 116 Query: 326 VQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA------QIASGMAY 379 + + ++ P E+ S +LD ++ + + + Q + + Q+ G+ Y Sbjct: 117 IAIKDIL--RPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKY 174 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLAR--LIEDNEYTARQGAKFPIKW-TAPEA 436 + +HRDL+ +N+LV EN K+ DFG+AR E+ +W APE Sbjct: 175 MHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPEL 234 Query: 437 AL-YGRFTIKSDVWSFGILLTELTTKGRVPYPG 468 L +T D+WS G + E+ + ++ +PG Sbjct: 235 MLSLHEYTQAIDLWSVGCIFGEMLARRQL-FPG 266 >4KIK-B nrPDB Length = 677 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 68/237 (28%), Positives = 108/237 (45%), Gaps = 33/237 (13%) Query: 249 PTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEV--WMGTWNGTTRVAIKTLKPGTMS 306 P+ QT G AWE+ +LG G FG V W G ++AIK + +S Sbjct: 11 PSLTTQTCG----AWEMKE-------RLGTGGFGNVIRWHNQETGE-QIAIKQCRQ-ELS 57 Query: 307 P---EAFLQEAQVMKKLRHEKLVQ-------LYAVVSEEPIYIVTEYMSKGSLLDFL-KG 355 P E + E Q+M++L H +V + + + + EY G L +L + Sbjct: 58 PRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQF 117 Query: 356 ETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILV--GEN-LVCKVADFGLAR 412 E LR ++ + + IAS + Y+ +HRDL+ NI++ GE L+ K+ D G A+ Sbjct: 118 ENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAK 177 Query: 413 LIEDNEY-TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPG 468 ++ T+ G +++ APE ++T+ D WSFG L E T R P Sbjct: 178 ELDQGSLCTSFVGT---LQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPN 231 >4CRS-A nrPDB Length = 341 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 63/232 (27%), Positives = 108/232 (46%), Gaps = 16/232 (6%) Query: 257 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSP----EAFL 311 +++ ++ + R L +G FG+V + + T + AIK LK G + ++ + Sbjct: 1 SMSQQRFQFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLM 60 Query: 312 QEAQVMK---KLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLV 367 E ++ + +RH LV L+A ++E + V EY + G L+ + + P+ V Sbjct: 61 CEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTDV---FSEPRAV 117 Query: 368 DMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKF 427 AA + G+ Y+ V+RDL+ N+L+ K+ADFGL + E Y R Sbjct: 118 FYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCK--EGMGYGDRTSTFC 175 Query: 428 PI-KWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 ++ APE +T D W G+L+ E+ G P+PG EV D + Sbjct: 176 GTPEFLAPEVLTETSYTRAVDWWGLGVLIYEMLV-GESPFPGDDEEEVFDSI 226 >3QA8-A nrPDB Length = 676 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 60/210 (28%), Positives = 95/210 (45%), Gaps = 20/210 (9%) Query: 275 KLGQGCFGEV--WMGTWNGTTRVAIKTLKPGTMSP---EAFLQEAQVMKKLRHEKLVQ-- 327 +LG G FG V W+ G +VAIK + +SP E + E Q+MKKL H +V Sbjct: 21 RLGTGGFGYVLRWIHQDTGE-QVAIKQCR-QELSPKNRERWCLEIQIMKKLNHPNVVSAR 78 Query: 328 -----LYAVVSEEPIYIVTEYMSKGSLLDFLKG-ETGKYLRLPQLVDMAAQIASGMAYVE 381 L + + + EY G L +L E L+ + + + I+S + Y+ Sbjct: 79 EVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALRYLH 138 Query: 382 RMNYVHRDLRAANILVG---ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438 +HRDL+ NI++ + L+ K+ D G A+ ++ E +++ APE Sbjct: 139 ENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGT--LQYLAPELLE 196 Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPG 468 ++T+ D WSFG L E T R P Sbjct: 197 QKKYTVTVDYWSFGTLAFECITGFRPFLPN 226 >4IAN-A nrPDB Length = 358 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 59/211 (27%), Positives = 101/211 (47%), Gaps = 18/211 (8%) Query: 277 GQGCFGEVWMGTWNG--TTRVAIKTLKPGTMSPEAFLQEAQVMKKL-------RHEKLVQ 327 GQG F V N VA+K ++ + + L+E + +KKL + L Sbjct: 39 GQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRL 98 Query: 328 LYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY--LRLPQLVDMAAQIASGMAYVERMNY 385 ++ + +V E +S +L + LK + GK L + + + Q+ + ++R N Sbjct: 99 FRHFYHKQHLCLVFEPLSM-NLREVLK-KYGKDVGLHIKAVRSYSQQLFLALKLLKRCNI 156 Query: 386 VHRDLRAANILVGEN-LVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI 444 +H D++ NILV E+ + K+ DFG A + DN+ T ++F + APE + + Sbjct: 157 LHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRF---YRAPEIIIGKSYDY 213 Query: 445 KSDVWSFGILLTELTTKGRVPYPGMVNREVL 475 D+WS G L EL T G++ +PG N +L Sbjct: 214 GIDMWSVGCTLYELYT-GKILFPGKTNNHML 243 >3D2K-A nrPDB Length = 272 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/250 (23%), Positives = 101/250 (40%), Gaps = 27/250 (10%) Query: 276 LGQGCFGEVWMGTWNGTT-----RVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYA 330 LG+G FG V++ + +V KT +E ++ LRH +++LY Sbjct: 20 LGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRREVEIQSHLRHPNILRLYG 79 Query: 331 VVSEEP-IYIVTEYMSKGS-------LLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 + +Y++ EY G+ L F + T Y+ ++A+ ++Y Sbjct: 80 YFHDATRVYLILEYAPLGTVYRELQKLSRFDEQRTATYI---------TELANALSYCHS 130 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 +HRD++ N+L+G N K+ADFG + + T G + + PE Sbjct: 131 KRVIHRDIKPENLLLGSNGELKIADFGWSVHAPSSRRTTLCGT---LDYLPPEMIEGRMH 187 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCW 502 K D+WS G+L E G P+ +E ++ R P E DL+ + Sbjct: 188 DEKVDLWSLGVLCYEFLV-GMPPFEAHTYQETYRRISR-VEFTFPDFVTEGARDLISRLL 245 Query: 503 RKEPEERPTF 512 + +R T Sbjct: 246 KHNASQRLTL 255 >5X3F-B nrPDB Length = 393 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 55/229 (24%), Positives = 105/229 (45%), Gaps = 14/229 (6%) Query: 276 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSP----EAFLQEAQVMKKLRHEKLVQL-Y 329 LG G FG V + + A+K L + E L E ++++ + LV+L + Sbjct: 92 LGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEF 151 Query: 330 AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 + +Y+V EY++ G + L+ G++ P AAQI Y+ ++ ++RD Sbjct: 152 SFKDNSNLYMVMEYVAGGEMFSHLR-RIGRFSE-PHARFYAAQIVLTFEYLHSLDLIYRD 209 Query: 390 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 449 L+ N+L+ + +V DFG A+ ++ +T ++ APE L + D W Sbjct: 210 LKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEY----LAPEIILSKGYNKAVDWW 265 Query: 450 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM 498 + G+L+ E+ G P+ ++ +++ G ++ P L DL+ Sbjct: 266 ALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLL 312 >5B2L-A nrPDB Length = 324 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 72/271 (26%), Positives = 119/271 (43%), Gaps = 31/271 (11%) Query: 275 KLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPE---AFLQEAQVMKKLRHEKLVQLYA 330 ++G G G+VW + T V A+K ++ E + V+K +VQ + Sbjct: 24 EMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFG 83 Query: 331 V-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV-ERMNYVHR 388 ++ ++I E M G+ + LK + L M I + Y+ E+ +HR Sbjct: 84 TFITNTDVFIAMELM--GTSAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHR 141 Query: 389 DLRAANILVGENLVCKVADFGLA-RLIEDNEYTARQGAKFPIKWTAPEAA-----LYGRF 442 D++ +NIL+ E K+ DFG++ RL++ T G + APE + Sbjct: 142 DVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCA---AYMAPERIDPPDPTKPDY 198 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQVERGYRMPCPPECPESL------H 495 I++DVWS GI L EL T G+ PY + EVL +V + PP P + Sbjct: 199 DIRADVWSLGISLVELAT-GQFPYKNCKTDFEVLTKVLQEE----PPLLPGHMGFSGDFQ 253 Query: 496 DLMCQCWRKEPEERPTFEYL--QAFLEDYFT 524 + C K+ +RP + L +F++ Y T Sbjct: 254 SFVKDCLTKDHRKRPKYNKLLEHSFIKRYET 284 >4YZB-A nrPDB Length = 491 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 72/250 (28%), Positives = 119/250 (47%), Gaps = 26/250 (10%) Query: 276 LGQGCFGEVWM------GTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329 LG+G FGEV + G ++ + +K T E L+E +++KKL H +++LY Sbjct: 38 LGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKT-DKELLLKEVELLKKLDHPNIMKLY 96 Query: 330 AVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA---QIASGMAYVERMNY 385 ++ Y+VTE + G L D E R + VD A Q+ SG+ Y+ + Sbjct: 97 EFFEDKGYFYLVTEVYTGGELFD----EIISRKRFSE-VDAARIIRQVLSGITYMHKNKI 151 Query: 386 VHRDLRAANILVG---ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 VHRDL+ N+L+ ++ ++ DFGL+ E T + K + L+G + Sbjct: 152 VHRDLKPENLLLENKRKDANIRIIDFGLSTHFES---TKKMKDKIGTAYYIAPEVLHGTY 208 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPCPPECPESLHDLMC 499 K DVWS G++L L + G P+ G ++L +VE+G + +P + E DL+ Sbjct: 209 DEKCDVWSTGVILYILLS-GCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAKDLIR 267 Query: 500 QCWRKEPEER 509 + P R Sbjct: 268 KMLAYVPTMR 277 >4FG9-A nrPDB Length = 320 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 67/253 (26%), Positives = 113/253 (44%), Gaps = 25/253 (9%) Query: 276 LGQGCFGEVWMGTWNGTTR-VAIKTL-------KPGTMSPEAFLQEAQVMKKLRHEKLVQ 327 LG G F EV + T + VAIK + K G+M E V+ K++H +V Sbjct: 26 LGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSME-----NEIAVLHKIKHPNIVA 80 Query: 328 LYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 L + S +Y++ + +S G L D + E G Y + Q+ + Y+ + V Sbjct: 81 LDDIYESGGHLYLIMQLVSGGELFDRIV-EKGFYTE-RDASRLIFQVLDAVKYLHDLGIV 138 Query: 387 HRDLRAANIL---VGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443 HRDL+ N+L + E+ ++DFGL+++ ED P + APE ++ Sbjct: 139 HRDLKPENLLYYSLDEDSKIMISDFGLSKM-EDPGSVLSTACGTP-GYVAPEVLAQKPYS 196 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV---ERGYRMPCPPECPESLHDLMCQ 500 D WS G++ L G P+ + ++ +Q+ E + P + +S D + Sbjct: 197 KAVDCWSIGVIAYILLC-GYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRH 255 Query: 501 CWRKEPEERPTFE 513 K+PE+R T E Sbjct: 256 LMEKDPEKRFTCE 268 >5N23-A nrPDB Length = 352 Score = 66.6 bits (161), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 58/229 (25%), Positives = 102/229 (44%), Gaps = 13/229 (5%) Query: 276 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSP----EAFLQEAQVMKKLRHEKLVQL-Y 329 LG G FG V + T A+K L + E L E ++ + + LV+L + Sbjct: 50 LGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNFPFLVKLEF 109 Query: 330 AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 + +Y+V EY G + L+ G++ P AAQI Y+ ++ ++RD Sbjct: 110 SFKDNSNLYMVLEYAPGGEMFSHLR-RIGRFSE-PHARFYAAQIVLTFEYLHSLDLIYRD 167 Query: 390 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 449 L+ N+L+ + KVADFG A+ ++ G ++ APE L + D W Sbjct: 168 LKPENLLIDQQGYIKVADFGFAKRVKGRTPWTLCGTP---EYLAPEIILSKGYNKAVDWW 224 Query: 450 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM 498 + G+L+ E+ G P+ ++ +++ G ++ P L DL+ Sbjct: 225 ALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLL 271 >2XS0-A nrPDB Length = 386 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 57/206 (27%), Positives = 98/206 (47%), Gaps = 24/206 (11%) Query: 295 VAIKTL----KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEP-------IYIVTEY 343 VAIK L + T + A+ +E +MK + H+ ++ L V + + +YIV E Sbjct: 54 VAIKKLSRPFQNQTHAKRAY-RELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMEL 112 Query: 344 MSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC 403 M +L ++ E L ++ + Q+ G+ ++ +HRDL+ +NI+V + Sbjct: 113 MD-ANLCQVIQME----LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL 167 Query: 404 KVADFGLARLIEDNEYTARQGAKFPIK--WTAPEAALYGRFTIKSDVWSFGILLTELTTK 461 K+ DFGLAR T+ F + + APE L + D+WS G ++ E+ K Sbjct: 168 KILDFGLAR----TAGTSFMMVPFVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEM-IK 222 Query: 462 GRVPYPGMVNREVLDQVERGYRMPCP 487 G V +PG + + ++V PCP Sbjct: 223 GGVLFPGTDHIDQWNKVIEQLGTPCP 248 >1ZWS-A nrPDB Length = 288 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 48/180 (26%), Positives = 86/180 (47%), Gaps = 12/180 (6%) Query: 305 MSPEAFLQEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRL 363 +S E +E +++++ H ++ L+ V + + ++ E +S G L DFL + L Sbjct: 57 VSREEIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKES--LSE 114 Query: 364 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLV----CKVADFGLARLIEDN-E 418 + QI G+ Y+ H DL+ NI++ + + K+ DFGLA IED E Sbjct: 115 EEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE 174 Query: 419 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 + G ++ APE Y +++D+WS G+ +T + G P+ G +E L + Sbjct: 175 FKNIFGTP---EFVAPEIVNYEPLGLEADMWSIGV-ITYILLSGASPFLGDTKQETLANI 230 >4ZSG-A nrPDB Length = 347 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 97/213 (45%), Gaps = 29/213 (13%) Query: 276 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAF---------LQEAQVMKKLRHEKL 325 +G G +G V T +VAIK + P AF L+E +++K +H+ + Sbjct: 15 IGNGAYGVVSSARRRLTGQQVAIKKI------PNAFDVVTNAKRTLRELKILKHFKHDNI 68 Query: 326 VQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA------QIASGMAY 379 + + ++ P E+ S +LD ++ + + + Q + + Q+ G+ Y Sbjct: 69 IAIKDIL--RPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKY 126 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLAR--LIEDNEYTARQGAKFPIKW-TAPEA 436 + +HRDL+ +N+LV EN K+ DFG+AR E+ +W APE Sbjct: 127 MHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPEL 186 Query: 437 AL-YGRFTIKSDVWSFGILLTELTTKGRVPYPG 468 L +T D+WS G + E+ + ++ +PG Sbjct: 187 MLSLHEYTQAIDLWSVGCIFGEMLARRQL-FPG 218 >4O2Z-A nrPDB Length = 377 Score = 65.9 bits (159), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 61/236 (25%), Positives = 105/236 (44%), Gaps = 36/236 (15%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTT--RVAIKTLKPGTMSPEA---FLQEAQVM 317 +E+P + L++ LG G +G + +G T +V+IK + E L+E +M Sbjct: 41 FEVPSKYTLLKI-LGMGAYG-IACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVLREIDMM 98 Query: 318 KKLRHEKLVQLYAVV--------SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD- 368 + HE L+ + ++ S E +Y+VT M + LR Q+++ Sbjct: 99 RFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDV---------DMNVVLRSRQVLEE 149 Query: 369 -----MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 423 QI G+ Y+ N HRDL+ AN++ + K+ DFGL+R + D Y+ Sbjct: 150 SHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSV-DVPYSELT 208 Query: 424 GAKFPIKWTAPEAALYG-RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 + PE L ++ D+WS G + E+ + V +PG R +DQ+ Sbjct: 209 DYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPV-FPG---RNTMDQL 260 >3ALO-A nrPDB Length = 327 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 72/276 (26%), Positives = 120/276 (43%), Gaps = 32/276 (11%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEA---FLQEAQVMK 318 W+ E L+ ++G+G +G V + ++ A+K ++ E + VM+ Sbjct: 17 WDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMR 76 Query: 319 KLRHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 +VQ Y A+ E +I E MS F K Y L ++ + Sbjct: 77 SSDCPYIVQFYGALFREGDCWICMELMSTS----FDKFYKYVYSVLDDVIPEEILGKITL 132 Query: 378 AYVERMNY-------VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIK 430 A V+ +N+ +HRD++ +NIL+ + K+ DFG++ + D+ R P Sbjct: 133 ATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRP-- 190 Query: 431 WTAPE----AALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPC 486 + APE +A + ++SDVWS GI L EL T GR PYP V DQ+ + + Sbjct: 191 YMAPERIDPSASRQGYDVRSDVWSLGITLYELAT-GRFPYPKW--NSVFDQLTQVVKGDP 247 Query: 487 PP-------ECPESLHDLMCQCWRKEPEERPTFEYL 515 P E S + + C K+ +RP ++ L Sbjct: 248 PQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKEL 283 >2A27-A nrPDB Length = 321 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 55/218 (25%), Positives = 98/218 (44%), Gaps = 15/218 (6%) Query: 305 MSPEAFLQEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRL 363 +S E +E +++++ H ++ L+ V + + ++ E +S G L DFL + L Sbjct: 57 VSREEIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQKES--LSE 114 Query: 364 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLV----CKVADFGLARLIEDN-E 418 + QI G+ Y+ H DL+ NI++ + + K+ DFGLA IED E Sbjct: 115 EEATSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVE 174 Query: 419 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQ- 477 + G ++ APE Y +++D+WS G+ +T + G P+ G +E L Sbjct: 175 FKNIFGTP---EFVAPEIVNYEPLGLEADMWSIGV-ITYILLSGASPFLGDTKQETLANI 230 Query: 478 --VERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFE 513 V + + E D + + KE +R T + Sbjct: 231 TAVSYDFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQ 268 >3NYO-A nrPDB Length = 576 Score = 65.5 bits (158), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 57/222 (25%), Positives = 104/222 (46%), Gaps = 9/222 (4%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRV----AIKTLKPGTMSPEAF-LQEAQVMKK 319 + + + R LG+G FGEV T ++ ++ + EA L E Q+++K Sbjct: 181 VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEK 240 Query: 320 LRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378 + +V L YA +++ + +V M+ G L + + V AA+I G+ Sbjct: 241 VNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLE 300 Query: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438 + R V+RDL+ NIL+ ++ +++D GLA + + + +G + + APE Sbjct: 301 DLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTI--KGRVGTVGYMAPEVVK 358 Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480 R+T D W+ G LL E+ G+ P+ + ++VER Sbjct: 359 NERYTFSPDWWALGCLLYEMIA-GQSPFQQRKKKIKREEVER 399 >4AGU-A nrPDB Length = 311 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 56/202 (27%), Positives = 98/202 (48%), Gaps = 14/202 (6%) Query: 275 KLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP---EAFLQEAQVMKKLRHEKLVQLYA 330 K+G+G +G V+ T + VAIK P + L+E +++K+L+H LV L Sbjct: 10 KIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKHPNLVNLLE 69 Query: 331 VVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 V + +++V EY L + + + G L + + Q + + + N +HRD Sbjct: 70 VFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVK--SITWQTLQAVNFCHKHNCIHRD 127 Query: 390 LRAANILVGENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAALYG--RFTIKS 446 ++ NIL+ ++ V K+ DFG ARL+ ++Y + A +W L G ++ Sbjct: 128 VKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVAT---RWYRSPELLVGDTQYGPPV 184 Query: 447 DVWSFGILLTELTTKGRVPYPG 468 DVW+ G + EL + G +PG Sbjct: 185 DVWAIGCVFAELLS-GVPLWPG 205 >6BDL-A nrPDB Length = 347 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 64/242 (26%), Positives = 104/242 (42%), Gaps = 13/242 (5%) Query: 276 LGQGCFGEVWMGTWNG--TTRVAIKTLKP----GTMSPEAFLQEAQVMKKLRHEKLVQLY 329 LG G FG V + + A+K LK T E E Q+M+ + +V+LY Sbjct: 42 LGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDFIVRLY 101 Query: 330 AVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 + +Y++ E G L L+ + G + A + AY+ ++R Sbjct: 102 RTFKDSKYLYMLMEACLGGELWTILR-DRGSFEDSTTRF-YTACVVEAFAYLHSKGIIYR 159 Query: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 448 DL+ N+++ K+ DFG A+ I + T ++ APE L I +D Sbjct: 160 DLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGT--PEYVAPEIILNKGHDISADY 217 Query: 449 WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM-PCPPECPESLHDLMCQCWRKEPE 507 WS GIL+ EL T G P+ G + + + RG M P + ++ +L+ + R P Sbjct: 218 WSLGILMYELLT-GSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPS 276 Query: 508 ER 509 ER Sbjct: 277 ER 278 >5IG1-A nrPDB Length = 344 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 65/254 (25%), Positives = 109/254 (42%), Gaps = 22/254 (8%) Query: 276 LGQGCFGEVW------MGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329 +G+G F V G +A+K+L+ ++ +E + L+HE +V + Sbjct: 25 IGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEIN--KIKREIGICSSLQHEHIVSMR 82 Query: 330 -AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 A E Y+V EY+S G L D + T K+ QI S + + N +HR Sbjct: 83 RAFRDESHFYLVFEYVSGGELFDEIV--TRKFYNEKDASACMHQILSALQHCHSKNIIHR 140 Query: 389 DLRAANILVGE---NLVCKVADFGLARLIEDN-EYTARQGAKFPIKWTAPEAALYGRFTI 444 DL+ N+L+ N K+ DFGLA ++E Y G + +PE + Sbjct: 141 DLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTP---GYLSPEVIRRVPYDT 197 Query: 445 KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER-GYRMPCP--PECPESLHDLMCQC 501 DVW+ G++L L G P+ ++++ Q++ Y P P + +L+ Sbjct: 198 AVDVWACGVILYILLV-GYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTAAKELIKAM 256 Query: 502 WRKEPEERPTFEYL 515 P+ RPT + L Sbjct: 257 LEPNPKRRPTVQEL 270 >4MWI-A nrPDB Length = 294 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 63/239 (26%), Positives = 117/239 (48%), Gaps = 25/239 (10%) Query: 295 VAIKT---LKPGTMSP--EAFLQEAQVMKKLRHEKLVQLYAVVSEEPIY-----IVTEYM 344 VAIK L+ G+++ + F +E + MKK +++++ + +E + IV EY Sbjct: 50 VAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYC 109 Query: 345 SKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY--VHRDLRAANILVGENLV 402 G+L + L E K L L + + + A G+ + +H +R++N LV + Sbjct: 110 ELGTLRELLDRE--KDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQGYQ 167 Query: 403 CKVADFGLAR------LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLT 456 K+A F L + L E T R + + E Y ++ +KS+++SFGI+L Sbjct: 168 VKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFY-QYDVKSEIYSFGIVLW 226 Query: 457 ELTTKGRVPYPGMVNREV--LDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFE 513 E+ T G +P+ G + ++ L V+R + P +CP L +++ +C +P RP+ + Sbjct: 227 EIAT-GDIPFQGCNSEKIRKLVAVKR-QQEPLGEDCPSELREIIDECRAHDPSVRPSVD 283 >5JZN-A nrPDB Length = 280 Score = 65.1 bits (157), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 66/237 (27%), Positives = 114/237 (48%), Gaps = 20/237 (8%) Query: 258 LAKDAWEIP---RESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTM-SPEAFLQ 312 ++++ ++IP E ++ +G G F V T R A+K +K E +Q Sbjct: 6 VSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQ 65 Query: 313 -EAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMA 370 E ++++++H +V L + +Y+V E + G L D + T KY M Sbjct: 66 NEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITS-TNKYTE-RDASGML 123 Query: 371 AQIASGMAYVERMNYVHRDLRAANILVGENL----VCKVADFGLARLIEDNEYTARQGAK 426 +AS + Y+ +N VHRD++ N+LV E+ K+ DFGLA +++ YT Sbjct: 124 YNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTV---CG 180 Query: 427 FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVL-DQVERG 481 P + APE + +K D+W+ G+ +T + G P+ G ++EVL DQ+ G Sbjct: 181 TP-TYVAPEIIAETGYGLKVDIWAAGV-ITYILLCGFPPFRGSGDDQEVLFDQILMG 235 >3VN9-A nrPDB Length = 340 Score = 65.1 bits (157), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 72/269 (26%), Positives = 126/269 (46%), Gaps = 22/269 (8%) Query: 263 WEIPRESLRLEVKLGQGCFGEV-WMGTWNGTTRVAIKTLKPGTMSPEA--FLQEAQV-MK 318 +E+ + L ++LG+G +G V M +A+K ++ S E L + + M+ Sbjct: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 Query: 319 KLRHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQ--LVDMAAQIAS 375 + V Y A+ E ++I E M SL F K K +P+ L +A I Sbjct: 106 TVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 Query: 376 GMAYVE-RMNYVHRDLRAANILVGENLVCKVADFGLA-RLIEDNEYTARQGAK--FPIKW 431 + ++ +++ +HRD++ +N+L+ K+ DFG++ L++ T G K + Sbjct: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPER 224 Query: 432 TAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPY-----PGMVNREVLDQVERGYRMPC 486 PE G +++KSD+WS GI + EL R PY P ++V++ E ++P Sbjct: 225 INPELNQKG-YSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLKQVVE--EPSPQLPA 280 Query: 487 PPECPESLHDLMCQCWRKEPEERPTFEYL 515 E + D QC +K +ERPT+ L Sbjct: 281 DKFSAEFV-DFTSQCLKKNSKERPTYPEL 308 >1ZXE-A nrPDB Length = 303 Score = 64.7 bits (156), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 64/278 (23%), Positives = 111/278 (39%), Gaps = 58/278 (20%) Query: 276 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYA---- 330 LGQG FG+V +R AIK ++ L E ++ L H+ +V+ YA Sbjct: 14 LGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQYVVRYYAAWLE 73 Query: 331 ----------VVSEEPIYIVTEYMSKGSLLDFLKGET-----GKYLRLPQLVDMAAQIAS 375 V + ++I EY +L D + E +Y RL + QI Sbjct: 74 RRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRDEYWRLFR------QILE 127 Query: 376 GMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE----------------DNEY 419 ++Y+ +HR+L+ NI + E+ K+ DFGLA+ + + Sbjct: 128 ALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSSDNL 187 Query: 420 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYP---GMVNREVLD 476 T+ G + + G + K D++S GI+ E+ YP GM +L Sbjct: 188 TSAIGTAMYVATEVLDGT--GHYNEKIDMYSLGIIFFEMI------YPFSTGMERVNILK 239 Query: 477 QVERGYRMPCPPECPESLHDLMCQCWR----KEPEERP 510 ++ R + PP+ ++ + + R +P +RP Sbjct: 240 KL-RSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRP 276 >3GC0-A nrPDB Length = 329 Score = 64.7 bits (156), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 101/213 (47%), Gaps = 32/213 (15%) Query: 275 KLGQGCFGEVWMGTWNGTTR-VAIKTLK--------PGTMSPEAFLQEAQVMKKLRHEKL 325 KLG+G +GEV+ T VAIK ++ PGT ++E ++K+L+H + Sbjct: 41 KLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEGVPGTA-----IREVSLLKELQHRNI 95 Query: 326 VQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN 384 ++L +V+ ++++ EY ++ L ++ +R+ + Q+ +G+ + Sbjct: 96 IELKSVIHHNHRLHLIFEY-AENDLKKYMDKNPDVSMRV--IKSFLYQLINGVNFCHSRR 152 Query: 385 YVHRDLRAANILV-----GENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAA 437 +HRDL+ N+L+ E V K+ DFGLAR I ++T + W P Sbjct: 153 CLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFT----HEIITLWYRPPEI 208 Query: 438 LYG--RFTIKSDVWSFGILLTELTTKGRVPYPG 468 L G ++ D+WS + E+ K + +PG Sbjct: 209 LLGSRHYSTSVDIWSIACIWAEMLMKTPL-FPG 240 >6HXF-B nrPDB Length = 302 Score = 64.7 bits (156), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 67/273 (24%), Positives = 122/273 (44%), Gaps = 20/273 (7%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSP-EAFLQEAQVMKKLRHE 323 P E + +LG G FG+V+ T A K ++ + E ++ E +++ H Sbjct: 17 PNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHP 76 Query: 324 KLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V+L A + ++I+ E+ G++ D + E + L PQ+ + Q+ + ++ Sbjct: 77 YIVKLLGAYYHDGKLWIMIEFCPGGAV-DAIMLELDRGLTEPQIQVVCRQMLEALNFLHS 135 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKF--PIKWTAPEAALYG 440 +HRDL+A N+L+ ++ADFG++ N T ++ F W APE + Sbjct: 136 KRIIHRDLKAGNVLMTLEGDIRLADFGVS---AKNLKTLQKRDSFIGTPYWMAPEVVMCE 192 Query: 441 R-----FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY--RMPCPPECPES 493 + K+D+WS GI L E+ + P+ + VL ++ + + P + Sbjct: 193 TMKDTPYDYKADIWSLGITLIEM-AQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVE 251 Query: 494 LHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 D + K PE RP+ L LE F S+ Sbjct: 252 FRDFLKIALDKNPETRPSAAQL---LEHPFVSS 281 >3KK8-A nrPDB Length = 284 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/222 (26%), Positives = 100/222 (45%), Gaps = 14/222 (6%) Query: 275 KLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQ---EAQVMKKLRHEKLVQLYA 330 +LG+G F V T A K + +S F + EA++ +KL+H +V+L+ Sbjct: 13 ELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLHD 72 Query: 331 VVSEEPI-YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 + EE Y+V + ++ G L + + ++ QI +AY VHR+ Sbjct: 73 SIQEESFHYLVFDLVTGGELFEDIVAR--EFYSEADASHCIQQILESIAYCHSNGIVHRN 130 Query: 390 LRAANILV---GENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 446 L+ N+L+ + K+ADFGLA IE N+ A G + +PE ++ Sbjct: 131 LKPENLLLASKAKGAAVKLADFGLA--IEVNDSEAWHGFAGTPGYLSPEVLKKDPYSKPV 188 Query: 447 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMPCP 487 D+W+ G++L L G P+ + Q++ G Y P P Sbjct: 189 DIWACGVILYILLV-GYPPFWDEDQHRLYAQIKAGAYDYPSP 229 >2BDW-A nrPDB Length = 362 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 59/222 (26%), Positives = 100/222 (45%), Gaps = 14/222 (6%) Query: 275 KLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQ---EAQVMKKLRHEKLVQLYA 330 +LG+G F V T A K + +S F + EA++ +KL+H +V+L+ Sbjct: 36 ELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHPNIVRLHD 95 Query: 331 VVSEEPI-YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 + EE Y+V + ++ G L + + ++ QI +AY VHR+ Sbjct: 96 SIQEESFHYLVFDLVTGGELFEDIVAR--EFYSEADASHCIQQILESIAYCHSNGIVHRN 153 Query: 390 LRAANILV---GENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 446 L+ N+L+ + K+ADFGLA IE N+ A G + +PE ++ Sbjct: 154 LKPENLLLASKAKGAAVKLADFGLA--IEVNDSEAWHGFAGTPGYLSPEVLKKDPYSKPV 211 Query: 447 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMPCP 487 D+W+ G++L L G P+ + Q++ G Y P P Sbjct: 212 DIWACGVILYILLV-GYPPFWDEDQHRLYAQIKAGAYDYPSP 252 >4FR4-A nrPDB Length = 384 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 56/228 (24%), Positives = 103/228 (45%), Gaps = 23/228 (10%) Query: 249 PTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTM-- 305 P + + + D +EI R +G+G FG+V + N T ++ A+K + Sbjct: 3 PPVFDENEDVNFDHFEILR-------AIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVE 55 Query: 306 --SPEAFLQEAQVMKKLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLR 362 +E Q+M+ L H LV L Y+ EE +++V + + G L L+ + + Sbjct: 56 RNEVRNVFKELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNV--HFK 113 Query: 363 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI-EDNEYTA 421 + ++ + Y++ +HRD++ NIL+ E+ + DF +A ++ + + T Sbjct: 114 EETVKLFICELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITT 173 Query: 422 RQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGILLTELTTKGRVPY 466 G K + APE + ++ D WS G+ EL +GR PY Sbjct: 174 MAGTK---PYMAPEMFSSRKGAGYSFAVDWWSLGVTAYEL-LRGRRPY 217 >5LOH-A nrPDB Length = 341 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 60/240 (25%), Positives = 102/240 (42%), Gaps = 18/240 (7%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKL----RHE 323 E + + +G FG+V++G G A+K +K M + + Q + + Sbjct: 36 EEFSIVKPISRGAFGKVYLGQ-KGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSP 94 Query: 324 KLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V LY ++ S +Y+V EY+ G + L Y V +++A + Y+ R Sbjct: 95 FIVHLYYSLQSANNVYLVMEYLIGGDVKSLL--HIYGYFDEEMAVKYISEVALALDYLHR 152 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE------YTARQGAKFPIKWTAPEA 436 +HRDL+ N+L+ K+ DFGL+++ + + T R P + APE Sbjct: 153 HGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTP-DYLAPEL 211 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 L D W+ G+ L E T G P+ ++V + + R PE E L D Sbjct: 212 LLGRAHGPAVDWWALGVCLFEFLT-GIPPFNDETPQQVFQNILK--RDIPWPEGEEKLSD 268 >3HDN-A nrPDB Length = 373 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 97/210 (46%), Gaps = 11/210 (5%) Query: 276 LGQGCFGEVWMGTWNGT-TRVAIKTLKPGTM----SPEAFLQEAQVM-KKLRHEKLVQL- 328 +G+G FG+V + A+K L+ + + + E V+ K ++H LV L Sbjct: 46 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLH 105 Query: 329 YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 ++ + + +Y V +Y++ G L L+ E + P+ AA+IAS + Y+ +N V+R Sbjct: 106 FSFQTADKLYFVLDYINGGELFYHLQRE--RCFLEPRARFYAAEIASALGYLHSLNIVYR 163 Query: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 448 DL+ NIL+ + DFGL + ++ T P ++ APE + D Sbjct: 164 DLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTP-EYLAPEVLHKQPYDRTVDW 222 Query: 449 WSFGILLTELTTKGRVPYPGMVNREVLDQV 478 W G +L E+ G P+ E+ D + Sbjct: 223 WCLGAVLYEMLY-GLPPFYSRNTAEMYDNI 251 >3FME-A nrPDB Length = 290 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 73/272 (26%), Positives = 128/272 (47%), Gaps = 26/272 (9%) Query: 262 AWEIPRESLRLEVKLGQGCFGEV-WMGTWNGTTRVAIKTLKPGTMSPEA--FLQEAQV-M 317 + E+ + L ++LG+G +G V M +A+K ++ S E L + + M Sbjct: 1 SMEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISM 60 Query: 318 KKLRHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQ--LVDMAAQIA 374 + + V Y A+ E ++I E M SL F K K +P+ L +A I Sbjct: 61 RTVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIV 119 Query: 375 SGMAYVE-RMNYVHRDLRAANILVGENLVCKVADFGLA-RLIEDNEYTARQGAKFPIKWT 432 + ++ +++ +HRD++ +N+L+ K+ DFG++ L++D G K + Sbjct: 120 KALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCK---PYM 176 Query: 433 APEAA---LYGR-FTIKSDVWSFGILLTELTTKGRVPY-----PGMVNREVLDQVERGYR 483 APE L + +++KSD+WS GI + EL R PY P ++V++ E + Sbjct: 177 APERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLKQVVE--EPSPQ 233 Query: 484 MPCPPECPESLHDLMCQCWRKEPEERPTFEYL 515 +P E + D QC +K +ERPT+ L Sbjct: 234 LPADKFSAEFV-DFTSQCLKKNSKERPTYPEL 264 >2YAB-A nrPDB Length = 361 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 47/177 (26%), Positives = 84/177 (47%), Gaps = 12/177 (6%) Query: 308 EAFLQEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQL 366 E +E +++++ H ++ L+ V + + ++ E +S G L DFL + L + Sbjct: 60 EEIEREVSILRQVLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKES--LSEEEA 117 Query: 367 VDMAAQIASGMAYVERMNYVHRDLRAANILVGENLV----CKVADFGLARLIEDN-EYTA 421 QI G+ Y+ H DL+ NI++ + + K+ DFGLA IED E+ Sbjct: 118 TSFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKN 177 Query: 422 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 G ++ APE Y +++D+WS G+ +T + G P+ G +E L + Sbjct: 178 IFGTP---EFVAPEIVNYEPLGLEADMWSIGV-ITYILLSGASPFLGDTKQETLANI 230 >3FI2-A nrPDB Length = 353 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 63/236 (26%), Positives = 108/236 (45%), Gaps = 39/236 (16%) Query: 295 VAIKTL----KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEP-------IYIVTEY 343 VAIK L + T + A+ +E +MK + H+ ++ L V + + +Y+V E Sbjct: 52 VAIKKLSRPFQNQTHAKRAY-RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMEL 110 Query: 344 MSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC 403 M +L ++ E L ++ + Q+ G+ ++ +HRDL+ +NI+V + Sbjct: 111 MD-ANLCQVIQME----LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL 165 Query: 404 KVADFGLARLIEDNEYTARQGAKFPIK-------WTAPEAALYGRFTIKSDVWSFGILLT 456 K+ DFGLAR TA G F + + APE L + D+WS G ++ Sbjct: 166 KILDFGLAR-------TA--GTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMG 216 Query: 457 ELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTF 512 E+ + ++ +PG R+ +DQ + P CPE + L R E RP + Sbjct: 217 EM-VRHKILFPG---RDYIDQWNKVIEQLGTP-CPEFMKKLQPTV-RNYVENRPKY 266 >1JNK-A nrPDB Length = 423 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 63/236 (26%), Positives = 108/236 (45%), Gaps = 39/236 (16%) Query: 295 VAIKTL----KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEP-------IYIVTEY 343 VAIK L + T + A+ +E +MK + H+ ++ L V + + +Y+V E Sbjct: 90 VAIKKLSRPFQNQTHAKRAY-RELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMEL 148 Query: 344 MSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC 403 M +L ++ E L ++ + Q+ G+ ++ +HRDL+ +NI+V + Sbjct: 149 MD-ANLCQVIQME----LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTL 203 Query: 404 KVADFGLARLIEDNEYTARQGAKFPIK-------WTAPEAALYGRFTIKSDVWSFGILLT 456 K+ DFGLAR TA G F + + APE L + D+WS G ++ Sbjct: 204 KILDFGLAR-------TA--GTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMG 254 Query: 457 ELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTF 512 E+ + ++ +PG R+ +DQ + P CPE + L R E RP + Sbjct: 255 EM-VRHKILFPG---RDYIDQWNKVIEQLGTP-CPEFMKKLQPTV-RNYVENRPKY 304 >1A81-A nrPDB Length = 254 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 38/98 (38%), Positives = 53/98 (54%), Gaps = 6/98 (6%) Query: 151 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 210 W+ GKI+R ESE+++L G FL+R + G+Y L + K V HY+I K Sbjct: 160 WFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCL--LHEGK---VLHYRIDKD 213 Query: 211 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC 248 +G I +F++L QLV +YS ADGL LT C Sbjct: 214 KTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPC 251 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 34/103 (33%), Positives = 48/103 (46%), Gaps = 11/103 (10%) Query: 151 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 210 ++FG ITR E+E L+ G +L+R+S G + LSV A G HY I + Sbjct: 7 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSV-----AHGRKAHHYTIERE 61 Query: 211 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKP 253 +G + I S L Y+S+ +DGL VC KP Sbjct: 62 LNGTYAIAGGRTHASPADLCHYHSQESDGL------VCLLKKP 98 >6E9W-A nrPDB Length = 443 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 57/206 (27%), Positives = 92/206 (44%), Gaps = 24/206 (11%) Query: 276 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGTM---SPEAFL-QEAQVMKKLRHEKLVQL-Y 329 +G+G FGEV + T +V A+K L M S AF +E +M +VQL Y Sbjct: 110 IGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFY 169 Query: 330 AVVSEEPIYIVTEYMSKGSLLDFLKGET--GKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 A + +Y+V EYM G L++ + K+ R A++ + + M ++H Sbjct: 170 AFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARF-----YTAEVVLALDAIHSMGFIH 224 Query: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA-------ALYG 440 RD++ N+L+ ++ K+ADFG + A + +PE YG Sbjct: 225 RDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYG 284 Query: 441 RFTIKSDVWSFGILLTELTTKGRVPY 466 R + D WS G+ L E+ G P+ Sbjct: 285 R---ECDWWSVGVFLYEMLV-GDTPF 306 >4JLC-A nrPDB Length = 657 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 105/213 (49%), Gaps = 28/213 (13%) Query: 276 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGT-MSP-EAFLQEAQVMKKLRHEKLVQLYAVV 332 LGQG V+ G T + A+K + + P + ++E +V+KKL H+ +V+L+A+ Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 75 Query: 333 SEEPI---YIVTEYMSKGSLLDFLKGETGKY-LRLPQLVDMAAQIASGMAYVERMNYVHR 388 E ++ E+ GSL L+ + Y L + + + + GM ++ VHR Sbjct: 76 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 135 Query: 389 DLRAANIL--VGEN--LVCKVADFGLARLIEDNE-YTARQGAKFPIKWTAPEAALYGRFT 443 D++ NI+ +GE+ V K+ DFG AR +ED+E + + G + ++ P+ +Y R Sbjct: 136 DIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPD--MYERAV 190 Query: 444 IKS----------DVWSFGILLTELTTKGRVPY 466 ++ D+WS G+ T G +P+ Sbjct: 191 LRKDHQKKYGATVDLWSVGVTFYHAAT-GSLPF 222 >4EUU-A nrPDB Length = 319 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 57/208 (27%), Positives = 102/208 (49%), Gaps = 18/208 (8%) Query: 276 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGT-MSP-EAFLQEAQVMKKLRHEKLVQLYAVV 332 LGQG V+ G T + AIK + + P + ++E +V+KKL H+ +V+L+A+ Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 76 Query: 333 SEEPI---YIVTEYMSKGSLLDFLKGETGKY-LRLPQLVDMAAQIASGMAYVERMNYVHR 388 E ++ E+ GSL L+ + Y L + + + + GM ++ VHR Sbjct: 77 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 136 Query: 389 DLRAANIL--VGEN--LVCKVADFGLARLIEDNE-YTARQGAKFPIKWTAPEAALY---- 439 +++ NI+ +GE+ V K+ DFG AR +ED+E + + G + + E A+ Sbjct: 137 NIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDH 196 Query: 440 -GRFTIKSDVWSFGILLTELTTKGRVPY 466 ++ D+WS G+ T G +P+ Sbjct: 197 QKKYGATVDLWSIGVTFYHAAT-GSLPF 223 >4EUT-A nrPDB Length = 396 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 105/213 (49%), Gaps = 28/213 (13%) Query: 276 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGT-MSP-EAFLQEAQVMKKLRHEKLVQLYAVV 332 LGQG V+ G T + AIK + + P + ++E +V+KKL H+ +V+L+A+ Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 76 Query: 333 SEEPI---YIVTEYMSKGSLLDFLKGETGKY-LRLPQLVDMAAQIASGMAYVERMNYVHR 388 E ++ E+ GSL L+ + Y L + + + + GM ++ VHR Sbjct: 77 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 136 Query: 389 DLRAANIL--VGEN--LVCKVADFGLARLIEDNE-YTARQGAKFPIKWTAPEAALYGRFT 443 +++ NI+ +GE+ V K+ DFG AR +ED+E + + G + ++ P+ +Y R Sbjct: 137 NIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPD--MYERAV 191 Query: 444 IKS----------DVWSFGILLTELTTKGRVPY 466 ++ D+WS G+ T G +P+ Sbjct: 192 LRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 223 >5E8V-A nrPDB Length = 316 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 69/292 (23%), Positives = 127/292 (43%), Gaps = 55/292 (18%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ---EAQVMK--KLRHEK 324 + L+ +G+G F EV+ T +T+ E + E + L+HE Sbjct: 11 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHEN 70 Query: 325 LVQLYAVVSEE-------PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 ++Q + +EE +++T + +KG+L ++L T + L + + +A G+ Sbjct: 71 ILQF--LTAEERKTELGKQYWLITAFHAKGNLQEYL---TRHVISWEDLRKLGSSLARGI 125 Query: 378 AYVE---------RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDN---EYTARQGA 425 A++ +M VHRDL+++NILV +L C + DFGL+ ++ + A G Sbjct: 126 AHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQ 185 Query: 426 KFPIKWTAPE--AALYGRFTIKS----DVWSFGILLTELTTK----GRV-----PYPGMV 470 ++ APE A+ ++S DV+S ++L E+T++ G V P+ V Sbjct: 186 VGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKV 245 Query: 471 NRE--VLDQVERGYRMPCPPECP---------ESLHDLMCQCWRKEPEERPT 511 V + PE P + + + + +CW +PE R T Sbjct: 246 REHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLT 297 >6NT9-A nrPDB Length = 742 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 105/213 (49%), Gaps = 28/213 (13%) Query: 276 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGT-MSP-EAFLQEAQVMKKLRHEKLVQLYAVV 332 LGQG V+ G T + AIK + + P + ++E +V+KKL H+ +V+L+A+ Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 74 Query: 333 SEEPI---YIVTEYMSKGSLLDFLKGETGKY-LRLPQLVDMAAQIASGMAYVERMNYVHR 388 E ++ E+ GSL L+ + Y L + + + + GM ++ VHR Sbjct: 75 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 134 Query: 389 DLRAANIL--VGEN--LVCKVADFGLARLIEDNE-YTARQGAKFPIKWTAPEAALYGRFT 443 +++ NI+ +GE+ V K+ DFG AR +ED+E + + G + ++ P+ +Y R Sbjct: 135 NIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTE---EYLHPD--MYERAV 189 Query: 444 IKS----------DVWSFGILLTELTTKGRVPY 466 ++ D+WS G+ T G +P+ Sbjct: 190 LRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 221 >2QLU-A nrPDB Length = 314 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 58/225 (25%), Positives = 105/225 (46%), Gaps = 34/225 (15%) Query: 265 IPRESLRLEVKLGQGCFGEVWMG-TWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKK--LR 321 +PR SL+L +G FG VW N V I L+ +++ E ++ ++ Sbjct: 12 VPRGSLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQ----DKQSWQSEREIFSTPGMK 67 Query: 322 HEKLVQLYAVVS-----EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 HE L+Q A E ++++T + KGSL D+LKG + +L +A ++ G Sbjct: 68 HENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITW---NELCHVAETMSRG 124 Query: 377 MAYVE-----------RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA-RQG 424 ++Y+ + + HRD ++ N+L+ +L +ADFGLA E + G Sbjct: 125 LSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHG 184 Query: 425 AKFPIKWTAPEAALYGRFT------IKSDVWSFGILLTELTTKGR 463 ++ APE L G ++ D+++ G++L EL ++ + Sbjct: 185 QVGTRRYMAPE-VLEGAINFQRDAFLRIDMYAMGLVLWELVSRCK 228 >3N9X-A nrPDB Length = 432 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 55/215 (25%), Positives = 94/215 (43%), Gaps = 35/215 (16%) Query: 276 LGQGCFGEVWMGTWNGTTR-VAIKTLK---PGTMSPEAFLQEAQVMKKLRHEKLVQLYAV 331 +G+G +G V++ T + VAIK + + + L+E ++ +L+ + +++LY + Sbjct: 34 IGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLYDL 93 Query: 332 VSEEPI------YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 + + + YIV E ++ L K T +L + + + G ++ Sbjct: 94 IIPDDLLKFDELYIVLE-IADSDLKKLFK--TPIFLTEEHIKTILYNLLLGENFIHESGI 150 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLI------------EDNEYTARQGAKFPIKWT- 432 +HRDL+ AN L+ ++ KV DFGLAR I E+NE + T Sbjct: 151 IHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKNLKKQLTS 210 Query: 433 --------APEAALYGRFTIKS-DVWSFGILLTEL 458 APE L KS D+WS G + EL Sbjct: 211 HVVTRWYRAPELILLQENYTKSIDIWSTGCIFAEL 245 >4XZ1-A nrPDB Length = 262 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 38/101 (37%), Positives = 52/101 (51%), Gaps = 6/101 (5%) Query: 151 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 210 WY +TR E+ER L + G FL+R + +G Y LS+ G V HY I + Sbjct: 166 WYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSL-----IYGKTVYHYLISQD 219 Query: 211 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTS 251 +G + I T+F++L QLV Y ADGL + L CP S Sbjct: 220 KAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNS 260 Score = 42.0 bits (97), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 27/98 (27%), Positives = 44/98 (44%), Gaps = 5/98 (5%) Query: 151 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 210 +++G I+R E+E L A G FL+R+ + G Y LS+ + H+ I + Sbjct: 13 FFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSL-----VHDVRFHHFPIERQ 67 Query: 211 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC 248 +G + I +L +YS+ DGL L C Sbjct: 68 LNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPC 105 >5O0Y-A nrPDB Length = 579 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 46/172 (26%), Positives = 85/172 (49%), Gaps = 20/172 (11%) Query: 312 QEAQVMKKLRHEKLVQLYAVVS--EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDM 369 +E ++ K+L H ++V+LY S + V EY +G+ LDF + K + + + Sbjct: 337 REYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEY-CEGNDLDFYLKQ-HKLMSEKEARSI 394 Query: 370 AAQIASGMAYVERMN--YVHRDLRAANILVGENLVC---KVADFGLARLIEDNEYTARQG 424 QI + + Y+ + +H DL+ NIL+ C K+ DFGL+++++D+ Y + G Sbjct: 395 IMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDG 454 Query: 425 AKFPIK------WTAPEAALYG----RFTIKSDVWSFGILLTELTTKGRVPY 466 + + + PE + G + + K DVWS G++ + GR P+ Sbjct: 455 MELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLY-GRKPF 505 >3TXO-A nrPDB Length = 353 Score = 62.4 bits (150), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 51/198 (25%), Positives = 91/198 (45%), Gaps = 11/198 (5%) Query: 276 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGTM----SPEAFLQEAQVMKKLR-HEKLVQLY 329 LG+G FG+V + T + A+K LK + E + E +++ R H L QL+ Sbjct: 31 LGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLF 90 Query: 330 AVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 + + ++ V E+++ G L+ + + + AA+I S + ++ ++R Sbjct: 91 CCFQTPDRLFFVMEFVNGGDLM--FHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYR 148 Query: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 448 DL+ N+L+ CK+ADFG+ + N T P + APE + D Sbjct: 149 DLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTP-DYIAPEILQEMLYGPAVDW 207 Query: 449 WSFGILLTELTTKGRVPY 466 W+ G+LL E+ G P+ Sbjct: 208 WAMGVLLYEMLC-GHAPF 224 >4I94-A nrPDB Length = 300 Score = 62.4 bits (150), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 55/237 (23%), Positives = 104/237 (43%), Gaps = 16/237 (6%) Query: 284 VWMGTWNGTTRVAIKTLKPGTM-SPEAFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVT 341 V+ G R+A+K + FL+EA+ + +LR+ ++ L E E ++ Sbjct: 45 VYKGKLENQRRIAVKRFNRKSWPDSRQFLEEAKAVGQLRNHRMANLLGCCYEDEERLLIA 104 Query: 342 EYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY-VERMNYVHRDLRAANILVGEN 400 E+M +L L + ++ + +A IA + Y + ++ DL A +L ++ Sbjct: 105 EFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRVLFDDD 164 Query: 401 LVCKVADFGLARLIEDNEYTARQGAKFP--IKWTAPEAALYGRFTIKSDVWSFGILLTEL 458 +++ FGL + +R G + + +T PE GR T +S ++SFG LL +L Sbjct: 165 ANPRLSCFGLMK-------NSRDGKSYSTNLAFTPPEYLRTGRVTPESVIYSFGTLLLDL 217 Query: 459 TTKGRVP----YPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPT 511 + +P + +R + ++ G + L L +C + EP ERP Sbjct: 218 LSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSSDDGTELIRLASRCLQYEPRERPN 274 >2JDO-A nrPDB Length = 342 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 61/246 (24%), Positives = 113/246 (45%), Gaps = 23/246 (9%) Query: 276 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPE----AFLQEAQVMKKLRHEKLVQL-Y 329 LG+G FG+V + T R A+K L+ + + + E++V++ RH L L Y Sbjct: 18 LGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKY 77 Query: 330 AVVSEEPIYIVTEYMSKGSLLDFLKGE---TGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 A + + + V EY + G L L E T + R A+I S + Y+ + V Sbjct: 78 AFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARF-----YGAEIVSALEYLHSRDVV 132 Query: 387 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 446 +RD++ N+++ ++ K+ DFGL + + T + P ++ APE + Sbjct: 133 YRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTP-EYLAPEVLEDNDYGRAV 191 Query: 447 DVWSFGILLTELTTKGRVPYPGMVNREVLDQV---ERGYRMPCPPECPESLHDLMCQCWR 503 D W G+++ E+ GR+P+ + + + + E + PE L L+ + Sbjct: 192 DWWGLGVVMYEMMC-GRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLL----K 246 Query: 504 KEPEER 509 K+P++R Sbjct: 247 KDPKQR 252 >2RIO-A nrPDB Length = 434 Score = 62.0 bits (149), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 70/275 (25%), Positives = 121/275 (44%), Gaps = 47/275 (17%) Query: 276 LGQGCFGEV-WMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY-AVVS 333 LG G G V + G++ G VA+K + A ++ + + H +++ Y + + Sbjct: 23 LGYGSSGTVVFQGSFQGRP-VAVKRMLID-FCDIALMEIKLLTESDDHPNVIRYYCSETT 80 Query: 334 EEPIYIVTEYMSKGSLLDFL--KGETGKYLRLPQL---VDMAAQIASGMAYVERMNYVHR 388 + +YI E + +L D + K + + L+L + + + QIASG+A++ + +HR Sbjct: 81 DRFLYIALE-LCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHSLKIIHR 139 Query: 389 DLRAANILV-------------GENLVCKVADFGLARLIEDNEYTARQGAKFP---IKWT 432 DL+ NILV ENL ++DFGL + ++ + + R P W Sbjct: 140 DLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSGTSGWR 199 Query: 433 APEAA-------LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP 485 APE R T D++S G + + +KG+ P+ +RE + RG Sbjct: 200 APELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRE--SNIIRGIFSL 257 Query: 486 CPPECPESLH---------DLMCQCWRKEPEERPT 511 +C LH DL+ Q +P +RPT Sbjct: 258 DEMKC---LHDRSLIAEATDLISQMIDHDPLKRPT 289 >3KN6-A nrPDB Length = 325 Score = 62.0 bits (149), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 39/149 (26%), Positives = 77/149 (51%), Gaps = 8/149 (5%) Query: 322 HEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 H +V+L+ V ++ ++V E ++ G L + +K + K+ + + ++ S ++++ Sbjct: 65 HPNIVKLHEVFHDQLHTFLVMELLNGGELFERIKKK--KHFSETEASYIMRKLVSAVSHM 122 Query: 381 ERMNYVHRDLRAANILV---GENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 437 + VHRDL+ N+L +NL K+ DFG ARL + + F + + APE Sbjct: 123 HDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPC-FTLHYAAPELL 181 Query: 438 LYGRFTIKSDVWSFGILLTELTTKGRVPY 466 + D+WS G++L + + G+VP+ Sbjct: 182 NQNGYDESCDLWSLGVILYTMLS-GQVPF 209 >3UIU-A nrPDB Length = 306 Score = 62.0 bits (149), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 41/184 (22%), Positives = 86/184 (46%), Gaps = 26/184 (14%) Query: 337 IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANIL 396 ++I E+ KG+L +++ G+ L +++ QI G+ Y+ +HRDL+ +NI Sbjct: 109 LFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIF 168 Query: 397 VGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLT 456 + + K+ DFGL ++++ R +K +++ +PE + + D+++ G++L Sbjct: 169 LVDTKQVKIGDFGLVTSLKND--GKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILA 226 Query: 457 EL---------TTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPE 507 EL T+K + ++ D+ E+ L+ + K+PE Sbjct: 227 ELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKT---------------LLQKLLSKKPE 271 Query: 508 ERPT 511 +RP Sbjct: 272 DRPN 275 >6ED6-A nrPDB Length = 415 Score = 62.0 bits (149), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 93/206 (45%), Gaps = 24/206 (11%) Query: 276 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGTM---SPEAFL-QEAQVMKKLRHEKLVQL-Y 329 +G+G FGEV + + +V A+K L M S AF +E +M +VQL Y Sbjct: 96 IGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFY 155 Query: 330 AVVSEEPIYIVTEYMSKGSLLDFLKGET--GKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 A + +Y+V EYM G L++ + K+ + A++ + + M +H Sbjct: 156 AFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKF-----YTAEVVLALDAIHSMGLIH 210 Query: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA-------ALYG 440 RD++ N+L+ ++ K+ADFG +++ A + +PE YG Sbjct: 211 RDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYG 270 Query: 441 RFTIKSDVWSFGILLTELTTKGRVPY 466 R + D WS G+ L E+ G P+ Sbjct: 271 R---ECDWWSVGVFLYEMLV-GDTPF 292 >4OTD-A nrPDB Length = 341 Score = 62.0 bits (149), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 60/221 (27%), Positives = 101/221 (45%), Gaps = 16/221 (7%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSP----EAFLQEAQVMKKLR- 321 E + LG+G FG+V + + + + AIK LK G + E+ + E +++ + Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILAAVTS 71 Query: 322 --HEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378 H LV L+ + E + V EY + G L+ + + P+ + +A + G+ Sbjct: 72 AGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSDV---FSEPRAIFYSACVVLGLQ 128 Query: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI-KWTAPEAA 437 ++ V+RDL+ N+L+ K+ADFGL + E Y R ++ APE Sbjct: 129 FLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCK--EGMGYGDRTSTFCGTPEFLAPEVL 186 Query: 438 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 +T D W G+LL E+ G P+PG EV D + Sbjct: 187 TDTSYTRAVDWWGLGVLLYEMLV-GESPFPGDDEEEVFDSI 226 >6O8B-A nrPDB Length = 665 Score = 61.6 bits (148), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 104/213 (48%), Gaps = 28/213 (13%) Query: 276 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGT-MSP-EAFLQEAQVMKKLRHEKLVQLYAVV 332 LGQG V+ G T + AIK + + P + ++E +V+KKL H+ +V+L+A+ Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE 82 Query: 333 SEEPI---YIVTEYMSKGSLLDFLKGETGKY-LRLPQLVDMAAQIASGMAYVERMNYVHR 388 E ++ E+ GSL L+ + Y L + + + + GM ++ VHR Sbjct: 83 EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHR 142 Query: 389 DLRAANIL--VGEN--LVCKVADFGLARLIEDNE-YTARQGAKFPIKWTAPEAALYGRFT 443 +++ NI+ +GE+ V K+ DFG AR +ED+E + G + ++ P+ +Y R Sbjct: 143 NIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTE---EYLHPD--MYERAV 197 Query: 444 IKS----------DVWSFGILLTELTTKGRVPY 466 ++ D+WS G+ T G +P+ Sbjct: 198 LRKDHQKKYGATVDLWSIGVTFYHAAT-GSLPF 229 >5U6Y-A nrPDB Length = 461 Score = 61.6 bits (148), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 65/249 (26%), Positives = 110/249 (44%), Gaps = 17/249 (6%) Query: 275 KLGQGCFGEV--WMGTWNGTTRVA--IKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYA 330 +LG+G F V + G A I T K + +EA++ + L+H +V+L+ Sbjct: 7 ELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHD 66 Query: 331 VVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 +SEE Y++ + ++ G L + + +Y QI + + +M VHRD Sbjct: 67 SISEEGHHYLIFDLVTGGELFEDIVAR--EYYSEADASHCIQQILEAVLHCHQMGVVHRD 124 Query: 390 LRAANILVGENL---VCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 446 L+ N+L+ L K+ADFGLA +E + A P + +PE + Sbjct: 125 LKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTP-GYLSPEVLRKDPYGKPV 183 Query: 447 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMPCP---PECPESLHDLMCQCW 502 D+W+ G++L L G P+ + Q++ G Y P P PE+ DL+ + Sbjct: 184 DLWACGVILYILLV-GYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEA-KDLINKML 241 Query: 503 RKEPEERPT 511 P +R T Sbjct: 242 TINPSKRIT 250 >5TUR-A nrPDB Length = 404 Score = 61.6 bits (148), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 46/150 (30%), Positives = 72/150 (48%), Gaps = 19/150 (12%) Query: 372 QIASGMAYVERMNYVHRDLRAANILVGENL-VCKVADFGLARLIEDNEYTARQGAKFPIK 430 Q+ + + +HRD++ NIL+ N K+ DFG L++D YT G + Sbjct: 241 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV--- 297 Query: 431 WTAPEAALYGRFTIKS-DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPC 486 ++ PE Y R+ +S VWS GILL ++ G +P+ E +++ RG +R Sbjct: 298 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF------EHDEEIIRGQVFFRQRV 350 Query: 487 PPECPESLHDLMCQCWRKEPEERPTFEYLQ 516 EC L+ C P +RPTFE +Q Sbjct: 351 SSEC----QHLIRWCLALRPSDRPTFEEIQ 376 >3OZ6-A nrPDB Length = 388 Score = 61.6 bits (148), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 71/256 (27%), Positives = 116/256 (45%), Gaps = 56/256 (21%) Query: 265 IPRESLR---LEVKLGQGCFGEVWMGTWNGTTRV-AIKTL----KPGTMSPEAFLQEAQV 316 + R LR L KLG+G +G VW T V A+K + + T + F +E + Sbjct: 3 VDRHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTF-REIMI 61 Query: 317 MKKLR-HEKLVQLYAVV---SEEPIYIVTEYMS-------KGSLLDFLKGETGKYLRLPQ 365 + +L HE +V L V+ ++ +Y+V +YM + ++L+ + + Y Q Sbjct: 62 LTELSGHENIVNLLNVLRADNDRDVYLVFDYMETDLHAVIRANILEPVHKQYVVY----Q 117 Query: 366 LVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED--------- 416 L+ + + SG +HRD++ +NIL+ KVADFGL+R + Sbjct: 118 LIKVIKYLHSG-------GLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIP 170 Query: 417 ---NEYTARQGAKFPI-------KW-TAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRV 464 NE T PI +W APE L ++T D+WS G +L E+ G+ Sbjct: 171 LSINENTENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILC-GKP 229 Query: 465 PYPGMVNREVLDQVER 480 +PG ++Q+ER Sbjct: 230 IFPG---SSTMNQLER 242 >2A1A-B nrPDB Length = 284 Score = 61.6 bits (148), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 60/271 (22%), Positives = 115/271 (42%), Gaps = 41/271 (15%) Query: 276 LGQGCFGEVWMGTW--NGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAV-- 331 +G G FG+V+ +G T V IK +K E +E + + KL H +V Sbjct: 19 IGSGGFGQVFKAKHRIDGKTYV-IKRVKYNNEKAE---REVKALAKLDHVNIVHYNGCWD 74 Query: 332 ---------------VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 + ++I E+ KG+L +++ G+ L +++ QI G Sbjct: 75 GFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELFEQITKG 134 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 + Y+ ++RDL+ +NI + + K+ DFGL ++++ R +K +++ +PE Sbjct: 135 VDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKND--GKRTRSKGTLRYMSPEQ 192 Query: 437 ALYGRFTIKSDVWSFGILLTEL---------TTKGRVPYPGMVNREVLDQVERGYRMPCP 487 + + D+++ G++L EL T+K + ++ D+ E+ Sbjct: 193 ISSQDYGKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGIISDIFDKKEKTLLQKLL 252 Query: 488 PECPESLHDL-----MCQCWRKEPE--ERPT 511 + PE + W+K PE ER T Sbjct: 253 SKKPEDRPNTSEILRTLTVWKKSPEKNERHT 283 >3MV5-A nrPDB Length = 342 Score = 61.6 bits (148), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 62/244 (25%), Positives = 112/244 (45%), Gaps = 18/244 (7%) Query: 276 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPE----AFLQEAQVMKKLRHEKLVQL-Y 329 LG+G FG+V + T R A+K LK + + L E +V++ RH L L Y Sbjct: 18 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 77 Query: 330 AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE-RMNYVHR 388 + + + + V EY + G L L E + + A+I S + Y+ N V+R Sbjct: 78 SFQTHDRLCFVMEYANGGELFFHLSRE--RVFSEDRARFYGAEIVSALDYLHSEKNVVYR 135 Query: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 448 DL+ N+++ ++ K+ DFGL + + T + P ++ APE + D Sbjct: 136 DLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVLEDNDYGRAVDW 194 Query: 449 WSFGILLTELTTKGRVPYPGMVNREVLDQV---ERGYRMPCPPECPESLHDLMCQCWRKE 505 W G+++ E+ GR+P+ + ++ + + E + PE L L+ +K+ Sbjct: 195 WGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLL----KKD 249 Query: 506 PEER 509 P++R Sbjct: 250 PKQR 253 >5KCV-A nrPDB Length = 460 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 62/244 (25%), Positives = 112/244 (45%), Gaps = 18/244 (7%) Query: 276 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPE----AFLQEAQVMKKLRHEKLVQL-Y 329 LG+G FG+V + T R A+K LK + + L E +V++ RH L L Y Sbjct: 170 LGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKY 229 Query: 330 AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE-RMNYVHR 388 + + + + V EY + G L L E + + A+I S + Y+ N V+R Sbjct: 230 SFQTHDRLCFVMEYANGGELFFHLSRE--RVFSEDRARFYGAEIVSALDYLHSEKNVVYR 287 Query: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 448 DL+ N+++ ++ K+ DFGL + + T + P ++ APE + D Sbjct: 288 DLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVLEDNDYGRAVDW 346 Query: 449 WSFGILLTELTTKGRVPYPGMVNREVLDQV---ERGYRMPCPPECPESLHDLMCQCWRKE 505 W G+++ E+ GR+P+ + ++ + + E + PE L L+ +K+ Sbjct: 347 WGLGVVMYEMMC-GRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLL----KKD 401 Query: 506 PEER 509 P++R Sbjct: 402 PKQR 405 >3BGP-A nrPDB Length = 333 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 46/150 (30%), Positives = 72/150 (48%), Gaps = 19/150 (12%) Query: 372 QIASGMAYVERMNYVHRDLRAANILVGENL-VCKVADFGLARLIEDNEYTARQGAKFPIK 430 Q+ + + +HRD++ NIL+ N K+ DFG L++D YT G + Sbjct: 170 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV--- 226 Query: 431 WTAPEAALYGRFTIKS-DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPC 486 ++ PE Y R+ +S VWS GILL ++ G +P+ E +++ RG +R Sbjct: 227 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF------EHDEEIIRGQVFFRQRV 279 Query: 487 PPECPESLHDLMCQCWRKEPEERPTFEYLQ 516 EC L+ C P +RPTFE +Q Sbjct: 280 SSEC----QHLIRWCLALRPSDRPTFEEIQ 305 >4RC3-A nrPDB Length = 289 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 46/150 (30%), Positives = 72/150 (48%), Gaps = 19/150 (12%) Query: 372 QIASGMAYVERMNYVHRDLRAANILVGENL-VCKVADFGLARLIEDNEYTARQGAKFPIK 430 Q+ + + +HRD++ NIL+ N K+ DFG L++D YT G + Sbjct: 126 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV--- 182 Query: 431 WTAPEAALYGRFTIKS-DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPC 486 ++ PE Y R+ +S VWS GILL ++ G +P+ E +++ RG +R Sbjct: 183 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF------EHDEEIIRGQVFFRQRV 235 Query: 487 PPECPESLHDLMCQCWRKEPEERPTFEYLQ 516 EC L+ C P +RPTFE +Q Sbjct: 236 SSEC----QHLIRWCLALRPSDRPTFEEIQ 261 >3BHH-A nrPDB Length = 295 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 50/196 (25%), Positives = 90/196 (45%), Gaps = 9/196 (4%) Query: 297 IKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPI-YIVTEYMSKGSLLDFLKG 355 I T K + +EA++ + L+H +V+L+ +SEE Y+V + ++ G L + + Sbjct: 37 INTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVA 96 Query: 356 ETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENL---VCKVADFGLAR 412 +Y QI + + +M VHRDL+ N+L+ K+ADFGLA Sbjct: 97 R--EYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAI 154 Query: 413 LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR 472 ++ ++ A P + +PE + D+W+ G++L L G P+ Sbjct: 155 EVQGDQQAWFGFAGTP-GYLSPEVLRKEAYGKPVDIWACGVILYILLV-GYPPFWDEDQH 212 Query: 473 EVLDQVERG-YRMPCP 487 ++ Q++ G Y P P Sbjct: 213 KLYQQIKAGAYDFPSP 228 >2VZ6-A nrPDB Length = 313 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 65/249 (26%), Positives = 110/249 (44%), Gaps = 17/249 (6%) Query: 275 KLGQGCFGEV--WMGTWNGTTRVA--IKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYA 330 +LG+G F V + G A I T K + +EA++ + L+H +V+L+ Sbjct: 29 ELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHD 88 Query: 331 VVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 +SEE Y++ + ++ G L + + +Y QI + + +M VHRD Sbjct: 89 SISEEGHHYLIFDLVTGGELFEDIVAR--EYYSEADASHCIQQILEAVLHCHQMGVVHRD 146 Query: 390 LRAANILVGENL---VCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 446 L+ N+L+ L K+ADFGLA +E + A P + +PE + Sbjct: 147 LKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTP-GYLSPEVLRKDPYGKPV 205 Query: 447 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMPCP---PECPESLHDLMCQCW 502 D+W+ G++L L G P+ + Q++ G Y P P PE+ DL+ + Sbjct: 206 DLWACGVILYILLV-GYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEA-KDLINKML 263 Query: 503 RKEPEERPT 511 P +R T Sbjct: 264 TINPSKRIT 272 >2YCR-A nrPDB Length = 323 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 69/261 (26%), Positives = 111/261 (42%), Gaps = 31/261 (11%) Query: 276 LGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMS--------PEAFLQ-EAQVMKKLRHEKL 325 LG G GEV + T + VAIK + + P ++ E +++KKL H + Sbjct: 18 LGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLNHPCI 77 Query: 326 VQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 +++ E YIV E M G L D + G K L+ Q+ + Y+ Sbjct: 78 IKIKNFFDAEDYYIVLELMEGGELFDKVVG--NKRLKEATCKLYFYQMLLAVQYLHENGI 135 Query: 386 VHRDLRAANILVG---ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL---- 438 +HRDL+ N+L+ E+ + K+ DFG ++++ + R P + APE + Sbjct: 136 IHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLM-RTLCGTPT-YLAPEVLVSVGT 193 Query: 439 --YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVL-DQVERGYRMPCP---PECPE 492 Y R D WS G++L + G P+ + L DQ+ G P E E Sbjct: 194 AGYNRAV---DCWSLGVILF-ICLSGYPPFSEHRTQVSLKDQITSGKYNFIPEVWAEVSE 249 Query: 493 SLHDLMCQCWRKEPEERPTFE 513 DL+ + +P+ R T E Sbjct: 250 KALDLVKKLLVVDPKARFTTE 270 >4YHJ-A nrPDB Length = 584 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 56/222 (25%), Positives = 103/222 (46%), Gaps = 12/222 (5%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRV----AIKTLKPGTMSPEAF-LQEAQVMKK 319 + + + R LG+G FGEV T ++ ++ + EA L E ++++K Sbjct: 182 VTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEK 241 Query: 320 LRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378 ++ +V L YA +++ + +V M+ G L + + V AA++ G+ Sbjct: 242 VQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLE 301 Query: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438 ++R V+RDL+ NIL+ + +++D GLA I + + +G + + APE Sbjct: 302 DLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRV--RGRVGTVGYMAPEVVN 359 Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVP---YPGMVNREVLDQ 477 ++T D W G L+ E+ +G P Y V E +DQ Sbjct: 360 NEKYTFSPDWWGLGCLIYEM-IQGHSPFKKYKEKVKWEEVDQ 400 >4QNY-A nrPDB Length = 354 Score = 60.5 bits (145), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 59/222 (26%), Positives = 102/222 (45%), Gaps = 21/222 (9%) Query: 253 PQTQGLAKDAWEIPRESLR--LEVKLGQGCFGEVWMG--TWNGTTRVAIKTLKPG----T 304 P T+ LA+ E+ R R LE +G G +G V T + VA+K + Sbjct: 3 PATKSLAELQAEVCRLDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEEV 62 Query: 305 MSPEAFLQEAQVMKKLRHEKLVQLYAVVS-EEP-----IYIVTEYMSKGSLLDFLKGETG 358 + + L+E +++ + ++ L +++ E+P YIV + M + L L+ +G Sbjct: 63 ILAKRILREIKLLAHFNDDNIIGLRNILTPEDPENFDHFYIVMDIM-ETDLKQVLR--SG 119 Query: 359 KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE 418 + L + Q + + +HRD+ ANILV N K+ DFGLA+ E+N+ Sbjct: 120 QELTEAHIQFFIYQALRALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAK--EEND 177 Query: 419 YTARQGAKFPIKW-TAPEAALYGR-FTIKSDVWSFGILLTEL 458 ++W APE + + ++ + DVW G +L EL Sbjct: 178 QGEYMTDYVTMRWYRAPELVMEDKDYSAQIDVWGIGCILGEL 219 >3I6U-A nrPDB Length = 419 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 69/270 (25%), Positives = 114/270 (42%), Gaps = 31/270 (11%) Query: 267 RESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMS--------PEAFLQ-EAQV 316 R+ + LG G GEV + T + VAI+ + + P ++ E ++ Sbjct: 134 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEI 193 Query: 317 MKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 +KKL H ++++ E YIV E M G L D + G K L+ Q+ Sbjct: 194 LKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFDKVVG--NKRLKEATCKLYFYQMLLA 251 Query: 377 MAYVERMNYVHRDLRAANILVG---ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 433 + Y+ +HRDL+ N+L+ E+ + K+ DFG ++++ + R P + A Sbjct: 252 VQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETS-LMRTLCGTPT-YLA 309 Query: 434 PEAAL------YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVL-DQVERGYRMPC 486 PE + Y R D WS G++L + G P+ + L DQ+ G Sbjct: 310 PEVLVSVGTAGYNRAV---DCWSLGVILF-ICLSGYPPFSEHRTQVSLKDQITSGKYNFI 365 Query: 487 P---PECPESLHDLMCQCWRKEPEERPTFE 513 P E E DL+ + +P+ R T E Sbjct: 366 PEVWAEVSEKALDLVKKLLVVDPKARFTTE 395 >3SV0-A nrPDB Length = 483 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 69/280 (24%), Positives = 118/280 (42%), Gaps = 37/280 (13%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL 328 RL K+G G FGE+++GT T VAIK T P+ L E+++ + L+ + Sbjct: 9 FRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQ-LLYESKIYRILQGGTGIPN 67 Query: 329 YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 E Y V G L+ L + L L ++ +A Q+ + + +V +++HR Sbjct: 68 VRWFGVEGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINRVEFVHSKSFLHR 127 Query: 389 DLRAANILVG----ENLVCKVADFGLARLIEDNE------YTARQGAKFPIKWTAPEAAL 438 D++ N L+G N V + DFGLA+ D Y + ++ + L Sbjct: 128 DIKPDNFLMGLGRRANQVY-IIDFGLAKKYRDTSTHQHIPYRENKNLTGTARYASVNTHL 186 Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGM------------VNREVLDQVE---RGYR 483 + + D+ S G +L +G +P+ G+ ++V +E RGY Sbjct: 187 GIEQSRRDDLESLGYVLMYF-LRGSLPWQGLKAGTKKQKYEKISEKKVATSIEALCRGY- 244 Query: 484 MPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 P E H C+ R +++P + YL+ D F Sbjct: 245 ---PTEFASYFH--YCRSLRF--DDKPDYSYLKRLFRDLF 277 >3SOC-A nrPDB Length = 322 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 57/214 (26%), Positives = 99/214 (46%), Gaps = 32/214 (14%) Query: 272 LEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQV--MKKLRHEKLVQLY 329 LEVK +G FG VW VA+K +++ E +V + ++HE ++Q Sbjct: 29 LEVK-ARGRFGCVWKAQLL-NEYVAVKIFP--IQDKQSWQNEYEVYSLPGMKHENILQFI 84 Query: 330 AVVS-----EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE--- 381 + ++++T + KGSL DFLK + +L +A +A G+AY+ Sbjct: 85 GAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSW---NELCHIAETMARGLAYLHEDI 141 Query: 382 -------RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA-RQGAKFPIKWTA 433 + HRD+++ N+L+ NL +ADFGLA E + G ++ A Sbjct: 142 PGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMA 201 Query: 434 PEAALYGRFT------IKSDVWSFGILLTELTTK 461 PE L G ++ D+++ G++L EL ++ Sbjct: 202 PE-VLEGAINFQRDAFLRIDMYAMGLVLWELASR 234 >4TN6-A nrPDB Length = 318 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 68/275 (24%), Positives = 117/275 (42%), Gaps = 29/275 (10%) Query: 271 RLEVKLGQGCFGEVWMGT-WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329 RL K+G G FG++++GT VAIK T P+ + E+++ K ++ + Sbjct: 10 RLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHI-ESKIYKMMQGGVGIPTI 68 Query: 330 AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 E Y V G L+ L + L ++ +A Q+ S + Y+ N++HRD Sbjct: 69 RWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRD 128 Query: 390 LRAANILVG----ENLVCKVADFGLARLIEDNEYTARQGAKFP------IKWTAPEAALY 439 ++ N L+G NLV + DFGLA+ D AR P + TA A++ Sbjct: 129 VKPDNFLMGLGKKGNLV-YIIDFGLAKKYRD----ARTHQHIPYRENKNLTGTARYASIN 183 Query: 440 GRFTI----KSDVWSFGILLTELTTKGRVPYPGM---VNREVLDQV-ERGYRMPCPPEC- 490 I + D+ S G +L G +P+ G+ R+ +++ E+ P C Sbjct: 184 THLGIEQSRRDDLESLGYVLMYFNL-GSLPWQGLKAATKRQKYERISEKKMSTPIEVLCK 242 Query: 491 --PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 P + C +++P + YL+ + F Sbjct: 243 GYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLF 277 >3SOA-A nrPDB Length = 444 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 66/256 (25%), Positives = 113/256 (44%), Gaps = 17/256 (6%) Query: 268 ESLRLEVKLGQGCFGEV--WMGTWNGTTRVA--IKTLKPGTMSPEAFLQEAQVMKKLRHE 323 E +L +LG+G F V + G A I T K + +EA++ + L+H Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHP 70 Query: 324 KLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V+L+ +SEE Y++ + ++ G L + + +Y QI + + + Sbjct: 71 NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAR--EYYSEADASHCIQQILEAVLHCHQ 128 Query: 383 MNYVHRDLRAANILVGENL---VCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 M VHR+L+ N+L+ L K+ADFGLA +E + A P + +PE Sbjct: 129 MGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTP-GYLSPEVLRK 187 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMPCP---PECPESLH 495 + D+W+ G++L L G P+ + Q++ G Y P P PE+ Sbjct: 188 DPYGKPVDLWACGVILYILLV-GYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEA-K 245 Query: 496 DLMCQCWRKEPEERPT 511 DL+ + P +R T Sbjct: 246 DLINKMLTINPSKRIT 261 >4Y83-A nrPDB Length = 332 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 55/241 (22%), Positives = 105/241 (43%), Gaps = 17/241 (7%) Query: 278 QGCFGEVWMGTWNGTT-RVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY-AVVSEE 335 +G FG+V++ T R+A K + P + ++ RHE + +LY AV+ E Sbjct: 83 RGAFGKVYLAQDIKTKKRMACKLIPVDQFKP----SDVEIQACFRHENIAELYGAVLWGE 138 Query: 336 PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANI 395 +++ E GS+L+ K E+ +R +++ + + G+ ++ +H D++ +NI Sbjct: 139 TVHLFMEAGEGGSVLE--KLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNI 196 Query: 396 LVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILL 455 + V DFGL+ + ++ Y + I + +PE L + K+D++S G L Sbjct: 197 VFMSTKAVLV-DFGLSVQMTEDVYFPKDLRGTEI-YMSPEVILCRGHSTKADIYSLGATL 254 Query: 456 TELTTKGRVPYPGMVNREVLDQVERGYRMPCPP------ECPESLHDLMCQCWRKEPEER 509 + T G P+ R PP +C + +L+ + P R Sbjct: 255 IHMQT-GTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHR 313 Query: 510 P 510 P Sbjct: 314 P 314 >5AWM-A nrPDB Length = 394 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 52/192 (27%), Positives = 92/192 (47%), Gaps = 34/192 (17%) Query: 295 VAIKTL----KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-------PIYIVTEY 343 VAIK L + T + A+ +E ++MK + H+ ++ L + + +Y+V E Sbjct: 72 VAIKKLSRPFQNVTHAKRAY-REFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMEL 130 Query: 344 MSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVC 403 M +L ++ + L ++ + Q+ G+ ++ +HRDL+ +NI+V + Sbjct: 131 MD-ANLCQVIQMD----LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTL 185 Query: 404 KVADFGLARLIEDNEYTARQGAKFPIK-------WTAPEAALYGRFTIKSDVWSFGILLT 456 K+ DFGLAR TA G F + + APE L +T D+WS G ++ Sbjct: 186 KILDFGLAR-------TA--GTTFMMTPYVVTRYYRAPEVILGMGYTENVDIWSVGCIMG 236 Query: 457 ELTTKGRVPYPG 468 E+ +G V +PG Sbjct: 237 EM-IRGGVLFPG 247 >3DLS-A nrPDB Length = 335 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 62/274 (22%), Positives = 119/274 (43%), Gaps = 43/274 (15%) Query: 276 LGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQ---------EAQVMKKLRHEKL 325 LG G FG VW + V +K +K + + +++ E ++ ++ H + Sbjct: 32 LGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHANI 91 Query: 326 VQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRL--PQLVDMAAQIASGMAYVER 382 +++ + + + +V E GS LD L ++ RL P + Q+ S + Y+ Sbjct: 92 IKVLDIFENQGFFQLVME--KHGSGLD-LFAFIDRHPRLDEPLASYIFRQLVSAVGYLRL 148 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKF-----PIKWTAPEAA 437 + +HRD++ NI++ E+ K+ DFG A +E +G F I++ APE Sbjct: 149 KDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLE-------RGKLFYTFCGTIEYCAPEVL 201 Query: 438 LYGRFT-IKSDVWSFGILLTEL------------TTKGRVPYPGMVNREVLDQVERGYRM 484 + + + ++WS G+ L L T + + P +V++E++ V G Sbjct: 202 MGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLV-SGLLQ 260 Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAF 518 P PE +L L+ W +P + + + F Sbjct: 261 PV-PERRTTLEKLVTDPWVTQPVNLADYTWEEVF 293 >2V7O-A nrPDB Length = 336 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 55/222 (24%), Positives = 99/222 (44%), Gaps = 13/222 (5%) Query: 275 KLGQGCFGEVWMGTWNGTTR----VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYA 330 +LG+G F V T+ I T K + +EA++ + L+H +V+L+ Sbjct: 38 ELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHD 97 Query: 331 VVSEEPI-YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 +SEE Y+V + ++ G L + + +Y QI + ++ + + VHRD Sbjct: 98 SISEEGFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIHQILESVNHIHQHDIVHRD 155 Query: 390 LRAANILVGENL---VCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 446 L+ N+L+ K+ADFGLA ++ + A P + +PE + Sbjct: 156 LKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTP-GYLSPEVLRKDPYGKPV 214 Query: 447 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMPCP 487 D+W+ G++L L G P+ ++ Q++ G Y P P Sbjct: 215 DIWACGVILYILLV-GYPPFWDEDQHKLYQQIKAGAYDFPSP 255 >4AF3-A nrPDB Length = 292 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 65/262 (24%), Positives = 108/262 (41%), Gaps = 22/262 (8%) Query: 255 TQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSPEA---- 309 T+ D +EI R LG+G FG V++ + VA+K L + E Sbjct: 17 TRHFTIDDFEIGR-------PLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQ 69 Query: 310 FLQEAQVMKKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFL-KGETGKYLRLPQLV 367 +E ++ L H +++LY + IY++ EY +G L L K T R ++ Sbjct: 70 LRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIM 129 Query: 368 DMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKF 427 + ++A + Y +HRD++ N+L+G K+ADFG + G Sbjct: 130 E---ELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGT-- 184 Query: 428 PIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP 487 + + PE K D+W G+L EL G P+ + E ++ + + P Sbjct: 185 -LDYLPPEMIEGRMHNEKVDLWCIGVLCYELLV-GNPPFESASHNETYRRIVK-VDLKFP 241 Query: 488 PECPESLHDLMCQCWRKEPEER 509 P DL+ + R P ER Sbjct: 242 ASVPTGAQDLISKLLRHNPSER 263 >3C51-A nrPDB Length = 543 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 57/248 (22%), Positives = 110/248 (44%), Gaps = 13/248 (5%) Query: 276 LGQGCFGEVWMGTWNGTTRV-----AIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL-Y 329 LG+G FGEV+ T ++ K + + E +++ K+ +V L Y Sbjct: 193 LGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILAKVHSRFIVSLAY 252 Query: 330 AVVSEEPIYIVTEYMSKGSLLDFLKG--ETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 A ++ + +V M+ G + + E + P+ + AQI SG+ ++ + N ++ Sbjct: 253 AFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIY 312 Query: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 447 RDL+ N+L+ ++ +++D GLA ++ + + A P + APE L + D Sbjct: 313 RDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTP-GFMAPELLLGEEYDFSVD 371 Query: 448 VWSFGILLTELTTKGRVPYPG---MVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRK 504 ++ G+ L E+ R P+ V + L Q + P + + D +K Sbjct: 372 YFALGVTLYEMIA-ARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQK 430 Query: 505 EPEERPTF 512 +PE+R F Sbjct: 431 DPEKRLGF 438 >4B8L-A nrPDB Length = 286 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 55/242 (22%), Positives = 98/242 (40%), Gaps = 17/242 (7%) Query: 276 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEA----FLQEAQVMKKLRHEKLVQLYA 330 LG+G FG V++ + A+K L + E +E ++ LRH ++++Y Sbjct: 23 LGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYN 82 Query: 331 VVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQL--VDMAAQIASGMAYVERMNYVH 387 + IY++ E+ +G L E K+ R + ++A + Y +H Sbjct: 83 YFHDRKRIYLMLEFAPRGELYK----ELQKHGRFDEQRSATFMEELADALHYCHERKVIH 138 Query: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 447 RD++ N+L+G K+ADFG + G + + PE K D Sbjct: 139 RDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGT---LDYLPPEMIEGKTHDEKVD 195 Query: 448 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPE 507 +W G+L E G P+ + E ++ + PP + DL+ + R P Sbjct: 196 LWCAGVLCYEFLV-GMPPFDSPSHTETHRRIV-NVDLKFPPFLSDGSKDLISKLLRYHPP 253 Query: 508 ER 509 +R Sbjct: 254 QR 255 >5JMQ-A nrPDB Length = 446 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 38/114 (33%), Positives = 57/114 (50%), Gaps = 15/114 (13%) Query: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVA------- 141 FVA+ DY + ET LSF +GE++ I+ T DWW G GYIP+N++ Sbjct: 48 FVAIADYTATDETQLSFLRGEKILILRQTTADWWWGE--RAGCCGYIPANHLGKQLEEYD 105 Query: 142 PSDSIQAEEWYFGKITRRESERLLLNAENPRGT----FLVRESETTKGAYCLSV 191 P D+ Q EE++ T + +L A+ PR T +++ E+ K L V Sbjct: 106 PEDTWQDEEYFDSYGTLKLHLEML--ADQPRTTKYHSVILQNKESLKDKVILDV 157 >3NIE-A nrPDB Length = 429 Score = 58.5 bits (140), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 54/232 (23%), Positives = 97/232 (41%), Gaps = 38/232 (16%) Query: 276 LGQGCFGEVWMG-TWNGTTRVAIKTLK---PGTMSPEAFLQEAQVMKKLRHEKLVQLYAV 331 +G+G +G V++ N VAIK + + + L+E ++ +L+ + +++L+ + Sbjct: 36 IGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSDYIIRLHDL 95 Query: 332 VSEEPI------YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 + E + YIV E ++ L K T +L + + + G ++ Sbjct: 96 IIPEDLLKFDELYIVLE-IADSDLKKLFK--TPIFLTEQHVKTILYNLLLGEKFIHESGI 152 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIED----------------------NEYTARQ 423 +HRDL+ AN L+ ++ K+ DFGLAR I N+ +Q Sbjct: 153 IHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGPHNKNLKKQ 212 Query: 424 GAKFPI-KW-TAPEAALYG-RFTIKSDVWSFGILLTELTTKGRVPYPGMVNR 472 + +W APE L +T D+WS G + EL + NR Sbjct: 213 LTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNR 264 >2WTK-B nrPDB Length = 373 Score = 58.5 bits (140), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 53/190 (27%), Positives = 88/190 (46%), Gaps = 18/190 (9%) Query: 310 FLQ-EAQVMKKLRHEKLVQLYAV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLV 367 FLQ E V K H +V A +++ +++VT +M+ GS D + + + Sbjct: 56 FLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIA 115 Query: 368 DMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGA-- 425 + + + Y+ M YVHR ++A++IL+ + KV GL + + RQ Sbjct: 116 YILQGVLKALDYIHHMGYVHRSVKASHILISVD--GKVYLSGLRSNLSMISHGQRQRVVH 173 Query: 426 ---KFPIK---WTAPEAA---LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLD 476 K+ +K W +PE L G + KSD++S GI EL G VP+ M ++L Sbjct: 174 DFPKYSVKVLPWLSPEVLQQNLQG-YDAKSDIYSVGITACEL-ANGHVPFKDMPATQMLL 231 Query: 477 QVERGYRMPC 486 + G +PC Sbjct: 232 EKLNG-TVPC 240 >2Y7J-A nrPDB Length = 365 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 57/231 (24%), Positives = 107/231 (46%), Gaps = 26/231 (11%) Query: 308 EAFLQEAQVMKKLR-HEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQ 365 EA +E +++++ H ++ L + S +++V + M KG L D+L + L + Sbjct: 144 EATRRETHILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVA--LSEKE 201 Query: 366 LVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE------- 418 + + ++++ N VHRDL+ NIL+ +N+ +++DFG + +E E Sbjct: 202 TRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCG 261 Query: 419 ---YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVL 475 Y A + K + T P YG+ + D+W+ G++L L G P+ +L Sbjct: 262 TPGYLAPEILKCSMDETHPG---YGK---EVDLWACGVILFTLLA-GSPPFWHRRQILML 314 Query: 476 DQVERGYRMPCPPECPE---SLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 + G PE + ++ DL+ + + +PE R T E QA +F Sbjct: 315 RMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAE--QALQHPFF 363 >2W96-B nrPDB Length = 306 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 53/201 (26%), Positives = 92/201 (45%), Gaps = 24/201 (11%) Query: 275 KLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMS---PEAFLQEAQVMKKLR---HEKLVQ 327 ++G G +G V+ + VA+K+++ P + ++E ++++L H +V+ Sbjct: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAFEHPNVVR 70 Query: 328 LYAVVS------EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 L V + E + +V E++ + L +L L + D+ Q G+ ++ Sbjct: 71 LMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLH 129 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT----APEAA 437 VHRDL+ NILV K+ADFGLAR+ + Q A P+ T APE Sbjct: 130 ANCIVHRDLKPENILVTSGGTVKLADFGLARIY------SYQMALDPVVVTLWYRAPEVL 183 Query: 438 LYGRFTIKSDVWSFGILLTEL 458 L + D+WS G + E+ Sbjct: 184 LQSTYATPVDMWSVGCIFAEM 204 >4CRL-A nrPDB Length = 406 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 55/206 (26%), Positives = 93/206 (45%), Gaps = 22/206 (10%) Query: 275 KLGQGCFGEVWMGTWNGTTRVAIKTLK--PGTMSPEAFLQEAQVMKKLRHEKLVQLYAVV 332 K+G+G +G V+ LK GT + +E ++++L+H ++ L V Sbjct: 29 KVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVF 88 Query: 333 ---SEEPIYIVTEYMSKG--SLLDFLKGETG--KYLRLPQ--LVDMAAQIASGMAYVERM 383 ++ ++++ +Y ++ F + K ++LP+ + + QI G+ Y+ Sbjct: 89 LSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHAN 148 Query: 384 NYVHRDLRAANILVG----ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT----APE 435 +HRDL+ ANILV E K+AD G ARL N P+ T APE Sbjct: 149 WVLHRDLKPANILVMGEGPERGRVKIADMGFARLF--NSPLKPLADLDPVVVTFWYRAPE 206 Query: 436 AALYGRFTIKS-DVWSFGILLTELTT 460 L R K+ D+W+ G + EL T Sbjct: 207 LLLGARHYTKAIDIWAIGCIFAELLT 232 >5FQD-C nrPDB Length = 341 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 67/280 (23%), Positives = 117/280 (41%), Gaps = 25/280 (8%) Query: 271 RLEVKLGQGCFGEVWMGT--WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL 328 +L K+G G FG++++ NG VA+K P+ L E+++ K L+ + Sbjct: 22 KLVRKIGSGSFGDIYLAINITNGE-EVAVKLESQKARHPQ-LLYESKLYKILQGGVGIPH 79 Query: 329 YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 +E Y V G L+ L + + ++ +A Q+ S + YV N++HR Sbjct: 80 IRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHR 139 Query: 389 DLRAANILVGENLVCK---VADFGLARLIEDNEYTARQGAKF----PIKWTAPEAALYGR 441 D++ N L+G C + DFGLA+ DN RQ + + TA A++ Sbjct: 140 DIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNR--TRQHIPYREDKNLTGTARYASINAH 197 Query: 442 FTI----KSDVWSFGILLTELTTKGRVPYPGM---VNREVLDQV-ERGYRMPCPPEC--- 490 I + D+ S G +L + +P+ G+ ++ +++ E+ P C Sbjct: 198 LGIEQSRRDDMESLGYVLMYF-NRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGF 256 Query: 491 PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 P + C EE P + YL+ F + QY Sbjct: 257 PAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQY 296 >2PMN-X nrPDB Length = 348 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 41/178 (23%), Positives = 86/178 (48%), Gaps = 19/178 (10%) Query: 288 TWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSK 346 T + +++IK+ + F E Q++ +++E + +++ + +YI+ EYM Sbjct: 74 TKSNNDKISIKS------KYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMEN 127 Query: 347 GSLLDF------LKGETGKYLRLPQLVDMAAQIASGMAYVER-MNYVHRDLRAANILVGE 399 S+L F L ++ + + + + + +Y+ N HRD++ +NIL+ + Sbjct: 128 DSILKFDEYFFVLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDK 187 Query: 400 NLVCKVADFGLARLIEDNEYTARQGAK--FPIKWTAPEAALYGRFTIKSDVWSFGILL 455 N K++DFG + + D + +G P ++ + E++ G K D+WS GI L Sbjct: 188 NGRVKLSDFGESEYMVDKKIKGSRGTYEFMPPEFFSNESSYNGA---KVDIWSLGICL 242 >4M7I-A nrPDB Length = 299 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 53/214 (24%), Positives = 95/214 (44%), Gaps = 34/214 (15%) Query: 276 LGQGCFGEVWMGTWN-GTTRVAIKTLK-PG-TMSPEAFLQEAQVMKKLRHEKLVQLYAVV 332 LG+G FG V+ AIK ++ P ++ E ++E + + KL H +V+ + Sbjct: 13 LGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAW 72 Query: 333 SEEP-------------IYIVTEYMSKGSLLDFLKGETGKYLRLPQL-VDMAAQIASGMA 378 E+ +YI + K +L D++ G R + + + QIA + Sbjct: 73 LEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVE 132 Query: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE--------------YTARQG 424 ++ +HRDL+ +NI + V KV DFGL ++ +E +T + G Sbjct: 133 FLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVG 192 Query: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTEL 458 K + +PE ++ K D++S G++L EL Sbjct: 193 TKL---YMSPEQIHGNSYSHKVDIFSLGLILFEL 223 >3E7O-A nrPDB Length = 360 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 44/165 (26%), Positives = 78/165 (47%), Gaps = 17/165 (10%) Query: 312 QEAQVMKKLRHEKLVQLYAVVSEEP-------IYIVTEYMSKGSLLDFLKGETGKYLRLP 364 +E ++K + H+ ++ L V + + +Y+V E M +L + E L Sbjct: 70 RELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMD-ANLCQVIHME----LDHE 124 Query: 365 QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDN-EYTARQ 423 ++ + Q+ G+ ++ +HRDL+ +NI+V + K+ DFGLAR N T Sbjct: 125 RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYV 184 Query: 424 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPG 468 ++ + APE L + D+WS G ++ EL KG V + G Sbjct: 185 VTRY---YRAPEVILGMGYKENVDIWSVGCIMGEL-VKGSVIFQG 225 >5VD3-A nrPDB Length = 311 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 43/146 (29%), Positives = 69/146 (47%), Gaps = 14/146 (9%) Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 +A++ VH D++ ANI +G CK+ DFGL L+E A + + ++ APE Sbjct: 170 LAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGL--LVELGTAGAGEVQEGDPRYMAPE- 226 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE----CPE 492 L G + +DV+S G+ + E+ +P+ G E Q+ +GY PPE Sbjct: 227 LLQGSYGTAADVFSLGLTILEVACNMELPHGG----EGWQQLRQGY---LPPEFTAGLSS 279 Query: 493 SLHDLMCQCWRKEPEERPTFEYLQAF 518 L ++ +P+ R T E L A Sbjct: 280 ELRSVLVMMLEPDPKLRATAEALLAL 305 >4C59-A nrPDB Length = 340 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 73/271 (26%), Positives = 113/271 (41%), Gaps = 36/271 (13%) Query: 270 LRLEVK--LGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPE-AFLQEAQVMKKLR-HEK 324 LRL V+ L +G F V+ G+ R A+K L A +QE MKKL H Sbjct: 27 LRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMKKLSGHPN 86 Query: 325 LVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLKG-ETGKYLRLPQLVDMAAQIA 374 +VQ + S + ++TE + KG L++FLK E+ L ++ + Q Sbjct: 87 IVQFCSAASIGKEESDTGQAEFLLLTE-LCKGQLVEFLKKMESRGPLSCDTVLKIFYQTC 145 Query: 375 SGMAYVERMN--YVHRDLRAANILVGENLVCKVADFGLARLIE---DNEYTARQGAKF-- 427 + ++ R +HRDL+ N+L+ K+ DFG A I D ++A++ A Sbjct: 146 RAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEE 205 Query: 428 -------PIKWTAPEAALYGRFTI--KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 P+ T LY F I K D+W+ G +L L + P+ + V Sbjct: 206 EITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQH-PFEDGAKLRI---V 261 Query: 479 ERGYRMPCPPECPESLHDLMCQCWRKEPEER 509 Y +P H L+ + PEER Sbjct: 262 NGKYSIPPHDTQYTVFHSLIRAMLQVNPEER 292 >6HV0-A nrPDB Length = 416 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 59/274 (21%), Positives = 120/274 (43%), Gaps = 28/274 (10%) Query: 276 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKL-RHEKLVQLYAVVSE 334 LG G G + VA+K + P S +E Q++++ H +++ + + Sbjct: 16 LGHGAEGTIVYRGMFDNRDVAVKRILPECFSFAD--REVQLLRESDEHPNVIRYFCTEKD 73 Query: 335 EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAAN 394 + + +L ++++ + +L L + + + Q SG+A++ +N VHRDL+ N Sbjct: 74 RQFQYIAIELCAATLQEYVEQKDFAHLGL-EPITLLQQTTSGLAHLHSLNIVHRDLKPHN 132 Query: 395 ILVGE-----NLVCKVADFGLAR--LIEDNEYTARQGAKFPIKWTAPEAA---LYGRFTI 444 IL+ + ++DFGL + + + ++ R G W APE T Sbjct: 133 ILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTY 192 Query: 445 KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC--PESLHDLMC--- 499 D++S G + + ++G P+ + R+ + G C +C PE D++ Sbjct: 193 TVDIFSAGCVFYYVISEGSHPFGKSLQRQA--NILLG---ACSLDCLHPEKHEDVIAREL 247 Query: 500 --QCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQ 531 + +P++RP+ +++ +F S E Q Q Sbjct: 248 IEKMIAMDPQKRPSAKHV--LKHPFFWSLEKQLQ 279 >3G2F-A nrPDB Length = 336 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 57/238 (23%), Positives = 108/238 (45%), Gaps = 49/238 (20%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKK--LRHEKL 325 ++L+L +G+G +G V+ G+ + VA+K + + F+ E + + + H+ + Sbjct: 13 DNLKLLELIGRGRYGAVYKGSLDERP-VAVKVFSFA--NRQNFINEKNIYRVPLMEHDNI 69 Query: 326 VQLYAVVSEEPI--------YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 + +V +E + +V EY GSL +L T ++ +L A + G+ Sbjct: 70 ARF--IVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRL---AHSVTRGL 124 Query: 378 AYVE---------RMNYVHRDLRAANILVGENLVCKVADFGLA------RLI----EDNE 418 AY+ + HRDL + N+LV + C ++DFGL+ RL+ EDN Sbjct: 125 AYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNA 184 Query: 419 YTARQGAKFPIKWTAPEAALYGRFTIKS--------DVWSFGILLTELTTKGRVPYPG 468 + G I++ APE L G ++ D+++ G++ E+ + +PG Sbjct: 185 AISEVGT---IRYMAPE-VLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPG 238 >4JG6-A nrPDB Length = 355 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 61/246 (24%), Positives = 105/246 (42%), Gaps = 23/246 (9%) Query: 252 KPQTQGLAKDAWEIPRESLRL----EVK--LGQGCFGEVWMGTWNGTT-RVAIKTLKPGT 304 K QT G+ ++ R S++ EVK +G G + T A+K + Sbjct: 13 KMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSK 72 Query: 305 MSPEAFLQEAQVMKKL-RHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLR 362 P +E +++ + +H ++ L V + + +Y+VTE M G LLD + + K+ Sbjct: 73 RDPT---EEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQ--KFFS 127 Query: 363 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILV----GENLVCKVADFGLARLIEDNE 418 + + I + Y+ VHRDL+ +NIL G ++ DFG A+ + E Sbjct: 128 EREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLR-AE 186 Query: 419 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPY---PGMVNREVL 475 + + APE + D+WS G+LL + T G P+ P E+L Sbjct: 187 NGLLMTPCYTANFVAPEVLERQGYDAACDIWSLGVLLYTMLT-GYTPFANGPDDTPEEIL 245 Query: 476 DQVERG 481 ++ G Sbjct: 246 ARIGSG 251 >5FET-A nrPDB Length = 847 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 92/209 (44%), Gaps = 13/209 (6%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTM----SPEAFLQEAQVMK 318 ++ L E +G+G FG V + T R A+K + ++ E ++ Sbjct: 529 KVEMHELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREITA 588 Query: 319 KLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 + H +++L + Y +TE ++ G L D ++ + G L PQ I + Sbjct: 589 ENDHPFIIRLVRTFKDSNCFYFLTELVTGGELYDAIR-KLG-LLSKPQAQFYLGSIILAI 646 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 437 Y+ N V+RDL+ NIL+ + K+ DFG A+ I+ YT P + APE Sbjct: 647 EYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKIQGRAYTL---VGTP-HYMAPEVI 702 Query: 438 LYGRFTIKSDVWSFGILLTELTTKGRVPY 466 L + D+W+ G+ L E G +P+ Sbjct: 703 LGKGYGCTVDIWALGVCLYEFIC-GPLPF 730 >1PHK-A nrPDB Length = 298 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 57/227 (25%), Positives = 105/227 (46%), Gaps = 36/227 (15%) Query: 308 EAFLQEAQVMKKLR-HEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFL-------KGETG 358 EA L+E +++K+ H ++QL + +V + M KG L D+L + ET Sbjct: 68 EATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKVTLSEKETR 127 Query: 359 KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE 418 K +R + + + ++N VHRDL+ NIL+ +++ K+ DFG + ++ E Sbjct: 128 KIMR---------ALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGE 178 Query: 419 YTARQGAKFPIKWTAPEAAL---------YGRFTIKSDVWSFGILLTELTTKGRVPYPGM 469 R+ P + APE YG+ + D+WS G+++ L G P+ Sbjct: 179 -KLREVCGTP-SYLAPEIIECSMNDNHPGYGK---EVDMWSTGVIMYTLLA-GSPPFWHR 232 Query: 470 VNREVLDQVERG-YRMPCP--PECPESLHDLMCQCWRKEPEERPTFE 513 +L + G Y+ P + +++ DL+ + +P++R T E Sbjct: 233 KQMLMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQKRYTAE 279 >2VN9-A nrPDB Length = 301 Score = 55.8 bits (133), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 57/222 (25%), Positives = 98/222 (44%), Gaps = 13/222 (5%) Query: 275 KLGQGCFGEV--WMGTWNGTTRVA--IKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYA 330 +LG+G F V M G A I T K + +EA++ + L+H +V+L+ Sbjct: 11 ELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHD 70 Query: 331 VVSEEPI-YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 +SEE Y+V + ++ G L + + +Y QI + + VHRD Sbjct: 71 SISEEGFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIQQILESVNHCHLNGIVHRD 128 Query: 390 LRAANILVG---ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 446 L+ N+L+ + K+ADFGLA ++ ++ A P + +PE + Sbjct: 129 LKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTP-GYLSPEVLRKDPYGKPV 187 Query: 447 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMPCP 487 D+W+ G++L L G P+ + Q++ G Y P P Sbjct: 188 DMWACGVILYILLV-GYPPFWDEDQHRLYQQIKAGAYDFPSP 228 >4NFN-A nrPDB Length = 309 Score = 55.8 bits (133), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 55/277 (19%), Positives = 112/277 (40%), Gaps = 23/277 (8%) Query: 258 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ-EAQV 316 + KD W++ + K+G G FGE++ + TR + P+ L+ E V Sbjct: 18 VVKDRWKVLK-------KIGGGGFGEIYEAM-DLLTRENVALKVESAQQPKQVLKMEVAV 69 Query: 317 MKKLR-HEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIAS 375 +KKL+ + + + E V + +L D + + L + + QI Sbjct: 70 LKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILE 129 Query: 376 GMAYVERMNYVHRDLRAANILVGE----NLVCKVADFGLARLIEDNEYTAR-----QGAK 426 + + + ++HRD++ +N +G C + DFGLAR + R G + Sbjct: 130 SIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFR 189 Query: 427 FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY--RM 484 +++ + A D+WS +L E G++P+ + ++E + ++ Y RM Sbjct: 190 GTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAV-GQLPWRKIKDKEQVGMIKEKYEHRM 248 Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLED 521 P H + + +P ++ + + E+ Sbjct: 249 -LLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFEN 284 >4BTK-A nrPDB Length = 337 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 55/277 (19%), Positives = 112/277 (40%), Gaps = 23/277 (8%) Query: 258 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ-EAQV 316 + KD W++ + K+G G FGE++ + TR + P+ L+ E V Sbjct: 53 VVKDRWKVLK-------KIGGGGFGEIYEAM-DLLTRENVALKVESAQQPKQVLKMEVAV 104 Query: 317 MKKLR-HEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIAS 375 +KKL+ + + + E V + +L D + + L + + QI Sbjct: 105 LKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILE 164 Query: 376 GMAYVERMNYVHRDLRAANILVGE----NLVCKVADFGLARLIEDNEYTAR-----QGAK 426 + + + ++HRD++ +N +G C + DFGLAR + R G + Sbjct: 165 SIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFR 224 Query: 427 FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY--RM 484 +++ + A D+WS +L E G++P+ + ++E + ++ Y RM Sbjct: 225 GTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAV-GQLPWRKIKDKEQVGMIKEKYEHRM 283 Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLED 521 P H + + +P ++ + + E+ Sbjct: 284 -LLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFEN 319 >6O6Q-A nrPDB Length = 335 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 58/250 (23%), Positives = 108/250 (43%), Gaps = 24/250 (9%) Query: 243 RLTTVCPTSKPQTQGLAKD---AWEIPRESLRLEVKLGQGCFGEVWMGT-WNGTTRVAIK 298 R+ ++KPQ+ D W P+E+ + KLG+G + EV++G +V IK Sbjct: 14 RVYADVLSTKPQSYWDYDDLNIKWN-PQENYEILRKLGRGKYSEVFLGIDLEKREKVVIK 72 Query: 299 TLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETG 358 LKP + + +E ++K L + V EP + + G + + + Sbjct: 73 VLKP--VKRKKIKREISILKNLVDGPNIIAMLDVVREP-----QSKTPGLIFEHINNIDF 125 Query: 359 KYLRLPQLVDM-----AAQIASGMAYVERMNYVHRDLRAANILVGENL-VCKVADFGLAR 412 + L P D ++ + Y M +HRD++ N+++ + + ++ D+GLA Sbjct: 126 RSL-YPTFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAE 184 Query: 413 LIE-DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMV 470 EY R +++ + PE + Y + D+WSFG +L + + G Sbjct: 185 YYHPGTEYNVRVASRY---FKGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKS 241 Query: 471 NREVLDQVER 480 N + L Q+ R Sbjct: 242 NTDQLVQIVR 251 >4X7Q-B nrPDB Length = 312 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 66/260 (25%), Positives = 112/260 (43%), Gaps = 31/260 (11%) Query: 271 RLEVKLGQGCFGEVWMG-TWNGTTRVAIKTL--------KPGTMSPEAFLQEAQVMKKLR 321 RL LG+G FG V+ G +VAIK + P + S L+ A + K Sbjct: 34 RLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGA 93 Query: 322 ---HEKLVQL--YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 H +++L + E + ++ + L D++ E G P Q+ + Sbjct: 94 GGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYIT-EKGPLGEGPSRC-FFGQVVAA 151 Query: 377 MAYVERMNYVHRDLRAANILVGENLVC-KVADFGLARLIEDNEYTARQGAKF--PIKWTA 433 + + VHRD++ NIL+ C K+ DFG L+ D YT G + P +W Sbjct: 152 IQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWI- 210 Query: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES 493 + + + + VWS GILL ++ G +P+ ++E+L + E + P+C Sbjct: 211 ---SRHQYHALPATVWSLGILLYDMVC-GDIPF--ERDQEIL-EAELHFPAHVSPDCCA- 262 Query: 494 LHDLMCQCWRKEPEERPTFE 513 L+ +C +P RP+ E Sbjct: 263 ---LIRRCLAPKPSSRPSLE 279 >5VDK-A nrPDB Length = 297 Score = 55.1 bits (131), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 66/277 (23%), Positives = 117/277 (42%), Gaps = 42/277 (15%) Query: 267 RESLRLEVKLGQGCFGEVW--MGTWNGTTRVAIKTLKPGT-MSPE-AFLQEAQVMKKL-R 321 +E L +E K+G G FG V+ + +G +++K T +S E + L E L Sbjct: 15 KEFLEVE-KIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGH 73 Query: 322 HEKLVQLYAVVSEEPIYIV-TEYMSKGSLLDFLKGET--GKYLRLPQLVDMAAQIASGMA 378 H +V+ Y+ +E+ I+ EY + GSL + T G + P+L D+ QI+ G+ Sbjct: 74 HPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLN 133 Query: 379 YVERMNYVHRDLRAANILV-----------------------GENLVCKVADFGLARLIE 415 Y+ + VH D++ +NI + N++ K+ D G A I Sbjct: 134 YIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSI- 192 Query: 416 DNEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREV 474 N+ +G ++F E R K+D+++ G+ + +P N Sbjct: 193 -NKPKVEEGDSRFLANEILQEDY---RHLPKADIFALGLTIAVAAGAESLP----TNGAA 244 Query: 475 LDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPT 511 + +G P E ES L+ + + E+RP+ Sbjct: 245 WHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPS 281 >4E7W-A nrPDB Length = 394 Score = 55.1 bits (131), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 55/211 (26%), Positives = 100/211 (47%), Gaps = 32/211 (15%) Query: 276 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFL-QEAQVMKKLRHEKLVQLYAVV-- 332 +G G FG V+ + VAIK + + + F +E Q+M+ ++H +V L A Sbjct: 48 IGNGSFGVVFQAKLVESDEVAIKKV----LQDKRFKNRELQIMRIVKHPNVVDLKAFFYS 103 Query: 333 -----SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA------QIASGMAYVE 381 E + +V EY+ + + + Y +L Q + M Q+ +AY+ Sbjct: 104 NGDKKDEVFLNLVLEYVPET-----VYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYIH 158 Query: 382 RMNYVHRDLRAANILVG-ENLVCKVADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALY 439 + HRD++ N+L+ + V K+ DFG A+ LI + +++ + APE ++ Sbjct: 159 SIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRY---YRAPE-LIF 214 Query: 440 G--RFTIKSDVWSFGILLTELTTKGRVPYPG 468 G +T D+WS G ++ EL +G+ +PG Sbjct: 215 GATNYTTNIDIWSTGCVMAEL-MQGQPLFPG 244 >5FG8-A nrPDB Length = 285 Score = 55.1 bits (131), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 54/222 (24%), Positives = 98/222 (44%), Gaps = 13/222 (5%) Query: 275 KLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQ---EAQVMKKLRHEKLVQLYA 330 +LG+G F V T A K + ++ F + EA++ +KL H +V+L+ Sbjct: 21 ELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLHD 80 Query: 331 VVSEEPI-YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 + EE Y+V + ++ G L + + ++ QI + + + VHRD Sbjct: 81 SIQEENYHYLVFDLVTGGELFEDIVAR--EFYSEADASHCIQQILESVNHCHQNGVVHRD 138 Query: 390 LRAANILV---GENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 446 L+ N+L+ + K+ADFGLA ++ ++ A G + +PE + Sbjct: 139 LKPENLLLASKAKGAAVKLADFGLAIEVQ-GDHQAWFGFAGTPGYLSPEVLKKEPYGKSV 197 Query: 447 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMPCP 487 D+W+ G++L L G P+ + Q++ G Y P P Sbjct: 198 DIWACGVILYILLV-GYPPFWDEDQHRLYSQIKAGAYDYPSP 238 >3RAW-A nrPDB Length = 381 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 62/233 (26%), Positives = 99/233 (42%), Gaps = 34/233 (14%) Query: 276 LGQGCFGEV--WMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRH-EKLVQLYAVV 332 LG+G FG+V + G ++VA+K ++ EA E V+KK++ +K + V+ Sbjct: 59 LGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVL 118 Query: 333 SEE------PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 + + I E + K + +FLK + LP + MA Q+ + ++ Sbjct: 119 MSDWFNFHGHMCIAFELLGKNTF-EFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLT 177 Query: 387 HRDLRAANILV---------GENLVC----------KVADFGLARLIEDNEYTARQGAKF 427 H DL+ NIL E+ C +VADFG A D+E+ A Sbjct: 178 HTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATF--DHEHHTTIVA-- 233 Query: 428 PIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480 + PE L + DVWS G +L E +G + NRE L +E+ Sbjct: 234 TRHYRPPEVILELGWAQPCDVWSIGCILFEY-YRGFTLFQTHENREHLVMMEK 285 >3GF9-A nrPDB Length = 295 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 25/63 (39%), Positives = 38/63 (60%), Gaps = 3/63 (4%) Query: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV-APSDSIQA 148 +A+YDY + E +LSF KG+ + ++N + DWW G TG PSNYV +DS + Sbjct: 22 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGE--INGVTGLFPSNYVKMTTDSDPS 79 Query: 149 EEW 151 ++W Sbjct: 80 QQW 82 >4NIF-A nrPDB Length = 333 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 59/249 (23%), Positives = 102/249 (40%), Gaps = 20/249 (8%) Query: 276 LGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSPEAFLQEAQVMKKL-RHEKLVQLYAVVS 333 +G G + E T A+K + P +E +++ + +H ++ L V Sbjct: 16 IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPS---EEIEILLRYGQHPNIITLKDVYD 72 Query: 334 E-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRA 392 + + +Y+VTE M G LLD + + K+ + + I + Y+ VHRDL+ Sbjct: 73 DGKHVYLVTELMRGGELLDKILRQ--KFFSEREASFVLHTIGKTVEYLHSQGVVHRDLKP 130 Query: 393 ANILV----GENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 448 +NIL G ++ DFG A+ + E + + APE + D+ Sbjct: 131 SNILYVDESGNPECLRICDFGFAKQLR-AENGLLMTPCYTANFVAPEVLKRQGYDEGCDI 189 Query: 449 WSFGILLTELTTKGRVPY---PGMVNREVLDQVERGYRMPCPPE---CPESLHDLMCQCW 502 WS GILL + G P+ P E+L ++ G E+ DL+ + Sbjct: 190 WSLGILLYTMLA-GYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKDLVSKML 248 Query: 503 RKEPEERPT 511 +P +R T Sbjct: 249 HVDPHQRLT 257 >3UDB-A nrPDB Length = 317 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 68/268 (25%), Positives = 112/268 (41%), Gaps = 39/268 (14%) Query: 265 IPRESLRLEV--KLGQGCFGEV-WMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR 321 I +S R E+ +G G FG M VA+K ++ G E +E + LR Sbjct: 14 IMHDSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKREIINHRSLR 73 Query: 322 HEKLVQLYAVV-SEEPIYIVTEYMSKGSLLD-------FLKGETGKYLRLPQLVDMAAQI 373 H +V+ V+ + + IV EY S G L + F + E + + Q+ Sbjct: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ---------QL 124 Query: 374 ASGMAYVERMNYVHRDLRAANILVGENLV--CKVADFGLARLIEDNEYTARQGAKFPIKW 431 SG++Y M HRDL+ N L+ + K+ADFG ++ ++ + A + Sbjct: 125 ISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSK--ASVLHSQPKSAVGTPAY 182 Query: 432 TAPEAALYGRFTIK-SDVWSFGILLTELTTKGRVPY-----PGMVNREVLDQVERGYRMP 485 APE L + K +DVWS G+ L + G P+ P + + + Y +P Sbjct: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIP 241 Query: 486 ----CPPECPESLHDLMCQCWRKEPEER 509 PEC L+ + + +P +R Sbjct: 242 DYVHISPEC----RHLISRIFVADPAKR 265 >4PL5-B nrPDB Length = 435 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 58/274 (21%), Positives = 119/274 (43%), Gaps = 28/274 (10%) Query: 276 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKL-RHEKLVQLYAVVSE 334 LG G G + VA+K + P S +E Q++++ H +++ + + Sbjct: 35 LGHGAEGTIVYKGMFDNRDVAVKRILPECFSFAD--REVQLLRESDEHPNVIRYFCTEKD 92 Query: 335 EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAAN 394 + + +L ++++ + +L L + + + Q SG+A++ +N VHRDL+ N Sbjct: 93 RQFQYIAIELCAATLQEYVEQKDFAHLGL-EPITLLHQTTSGLAHLHSLNIVHRDLKPHN 151 Query: 395 ILVGE-----NLVCKVADFGLAR--LIEDNEYTARQGAKFPIKWTAPEAA---LYGRFTI 444 IL+ + ++DFGL + + + ++ R G W APE T Sbjct: 152 ILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKDNPTY 211 Query: 445 KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES-------LHDL 497 D++S G + + ++G P+ + R+ + G C +C S +L Sbjct: 212 TVDIFSAGCVFYYVISEGYHPFGKSLQRQA--NILLG---ACNLDCFHSDKHEDVIAREL 266 Query: 498 MCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQ 531 + + +P++RP+ +++ +F S E Q Q Sbjct: 267 IEKMIAMDPQQRPSAKHV--LKHPFFWSLEKQLQ 298 >5X8I-B nrPDB Length = 346 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 67/242 (27%), Positives = 97/242 (40%), Gaps = 36/242 (14%) Query: 269 SLRLEV--KLGQGCFGEV--WMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHE- 323 S R E+ LG+G FG+V + G VA+K +K EA E QV++ L Sbjct: 12 SARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTD 71 Query: 324 -----KLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 + VQ+ I IV E + S DF+K RL + MA QI + Sbjct: 72 PNSTFRCVQMLEWFEHHGHICIVFELLGL-STYDFIKENGFLPFRLDHIRKMAYQICKSV 130 Query: 378 AYVERMNYVHRDLRAANILVGE-------------------NLVCKVADFGLARLIEDNE 418 ++ H DL+ NIL + N KV DFG A +D Sbjct: 131 NFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATY-DDEH 189 Query: 419 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 ++ + + APE L ++ DVWS G +L E G +P ++E L + Sbjct: 190 HSTLVSTR---HYRAPEVILALGWSQPCDVWSIGCILIEYYL-GFTVFPTHDSKEHLAMM 245 Query: 479 ER 480 ER Sbjct: 246 ER 247 >5IKW-A nrPDB Length = 310 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 53/225 (23%), Positives = 95/225 (42%), Gaps = 34/225 (15%) Query: 262 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTM-SPEAFLQEAQVMKKL 320 + + R + LE L +G F V++ +G R A+K + M +E +MK+L Sbjct: 8 VFAVGRHQVTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKREITIMKEL 67 Query: 321 RHEKLVQLYAVVSEEPI-------YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373 K + Y + I I+ EY G +++ + + P+++ + Sbjct: 68 SGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDT 127 Query: 374 ASGMAYVERMN--YVHRDLRAANILVGENLVCKVADFGLA------------RLIED--N 417 +A + + +HRDL+ NIL+ + + DFG A ++E+ Sbjct: 128 CEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIK 187 Query: 418 EYTARQGAKFPIKWTAPEAA-LYGR--FTIKSDVWSFGILLTELT 459 +YT + + APE LYG T K+D+W+ G LL +L Sbjct: 188 KYTT-------LSYRAPEMINLYGGKPITTKADIWALGCLLYKLC 225 >5DYK-A nrPDB Length = 853 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 54/214 (25%), Positives = 93/214 (43%), Gaps = 23/214 (10%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTM----SPEAFLQEAQVMK 318 ++ + L E +G+G FG V + T R A+K + ++ E ++ Sbjct: 535 KVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITA 594 Query: 319 KLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQ----- 372 + H +++L + Y +TE ++ G L D ++ +L L AQ Sbjct: 595 ENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIR-------KLGLLSKSQAQFYLGS 647 Query: 373 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT 432 I + Y+ N V+RDL+ NIL+ + K+ DFG A+ ++ YT P + Sbjct: 648 IILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTL---VGTP-HYM 703 Query: 433 APEAALYGRFTIKSDVWSFGILLTELTTKGRVPY 466 APE L + D+W+ GI L E G +P+ Sbjct: 704 APEVILGKGYGCTVDIWALGICLYEFIC-GPLPF 736 >5Y86-A nrPDB Length = 588 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 56/220 (25%), Positives = 100/220 (45%), Gaps = 22/220 (10%) Query: 264 EIPRESL--RLEV--KLGQGCFGEVWMGTWNGTTR--VAIKTLKPGTMSPEAFLQEAQVM 317 +PR+ L R EV +G+G FG+V ++ R VA+K ++ +E +++ Sbjct: 199 HVPRDHLAYRYEVLKIIGKGSFGQVAR-VYDHKLRQYVALKMVRNEKRFHRQAAEEIRIL 257 Query: 318 KKLRHEK-------LVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMA 370 + L+ + + L + + + E +S L + +K + + + A Sbjct: 258 EHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFA 316 Query: 371 AQIASGMAYVERMNYVHRDLRAANILVGEN--LVCKVADFGLARLIEDNEYTARQGAKFP 428 I + + + +H DL+ NIL+ + KV DFG + YT Q ++F Sbjct: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQ-SRF- 374 Query: 429 IKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPG 468 + APE L R++ D+WSFG +L EL T G+ +PG Sbjct: 375 --YRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPG 411 >2VD5-A nrPDB Length = 412 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 51/159 (32%), Positives = 76/159 (47%), Gaps = 23/159 (14%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKT------LKPGTMSPEAFLQEAQVM 317 + R+ + +G+G F EV + T +V A+K LK G +S F +E V+ Sbjct: 58 LQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVS--CFREERDVL 115 Query: 318 KKLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLK--GETGKYLRLPQLVDMA---- 370 + QL +A E +Y+V EY G LL L GE R+P +MA Sbjct: 116 VNGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGE-----RIP--AEMARFYL 168 Query: 371 AQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFG 409 A+I + V R+ YVHRD++ NIL+ ++ADFG Sbjct: 169 AEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFG 207 >2BUJ-A nrPDB Length = 317 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 62/269 (23%), Positives = 109/269 (40%), Gaps = 25/269 (9%) Query: 275 KLGQGCFGEVWM--GTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVV 332 KLG+G F V + G +G + L E +EA + + H +++L A Sbjct: 36 KLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILRLVAYC 95 Query: 333 SEE-----PIYIVTEYMSKGSLLDFLK--GETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 E +++ + +G+L + ++ + G +L Q++ + I G+ + Y Sbjct: 96 LRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHAKGY 155 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR---- 441 HRDL+ NIL+G+ + D G + +RQ W A + R Sbjct: 156 AHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQ-DWAAQRCTISYRAPEL 214 Query: 442 FTIKS--------DVWSFGILLTELTTKGRVPYPGMVNR--EVLDQVERGYRMPCPPECP 491 F+++S DVWS G +L + G PY + + V V+ +P P Sbjct: 215 FSVQSHCVIDERTDVWSLGCVLYAMMF-GEGPYDMVFQKGDSVALAVQNQLSIPQSPRHS 273 Query: 492 ESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 +L L+ +P +RP L + LE Sbjct: 274 SALWQLLNSMMTVDPHQRPHIPLLLSQLE 302 >3QWY-A nrPDB Length = 308 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 23/55 (41%), Positives = 35/55 (63%), Gaps = 1/55 (1%) Query: 86 VTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 + V + + ETDL F++GERL+I++ T DWW A + + G TG +P+NYV Sbjct: 147 IEVVVGTFKFTGERETDLPFEQGERLEILSKTNQDWWEARN-ALGTTGLVPANYV 200 Score = 36.6 bits (83), Expect = 0.030, Method: Compositional matrix adjust. Identities = 23/66 (34%), Positives = 37/66 (56%), Gaps = 3/66 (4%) Query: 144 DSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVK 203 D + +YF ++R E+ +LL + GTFL+R+S + G Y L+V + D +G V Sbjct: 36 DPFEWRSFYFPGMSREEAHKLLGEPQVSIGTFLMRDS-SRPGEYSLTVREAD--EGNAVC 92 Query: 204 HYKIRK 209 HY I + Sbjct: 93 HYLIER 98 >1NY3-A nrPDB Length = 400 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 44/189 (23%), Positives = 77/189 (40%), Gaps = 19/189 (10%) Query: 337 IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANIL 396 + IV E + G L ++ + + ++ I + Y+ +N HRD++ N+L Sbjct: 134 LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 193 Query: 397 VGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 453 N + K+ DFG A+ E + + + + APE ++ D+WS G+ Sbjct: 194 YTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV 251 Query: 454 LLTEL--------TTKGRVPYPGMVNREVLDQVERGYRMPCP--PECPESLHDLMCQCWR 503 ++ L + G PGM R + Q Y P P E E + L+ + Sbjct: 252 IMYILLCGYPPFYSNHGLAISPGMKTRIRMGQ----YEFPNPEWSEVSEEVKMLIRNLLK 307 Query: 504 KEPEERPTF 512 EP +R T Sbjct: 308 TEPTQRMTI 316 >2OZA-A nrPDB Length = 356 Score = 53.5 bits (127), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 44/189 (23%), Positives = 77/189 (40%), Gaps = 19/189 (10%) Query: 337 IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANIL 396 + IV E + G L ++ + + ++ I + Y+ +N HRD++ N+L Sbjct: 90 LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 149 Query: 397 VGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 453 N + K+ DFG A+ E + + + + APE ++ D+WS G+ Sbjct: 150 YTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV 207 Query: 454 LLTEL--------TTKGRVPYPGMVNREVLDQVERGYRMPCP--PECPESLHDLMCQCWR 503 ++ L + G PGM R + Q Y P P E E + L+ + Sbjct: 208 IMYILLCGYPPFYSNHGLAISPGMKTRIRMGQ----YEFPNPEWSEVSEEVKMLIRNLLK 263 Query: 504 KEPEERPTF 512 EP +R T Sbjct: 264 TEPTQRMTI 272 >2H34-A nrPDB Length = 309 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 56/246 (22%), Positives = 98/246 (39%), Gaps = 9/246 (3%) Query: 271 RLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ-----EAQVMKKLRHEKL 325 RL +G+G G+V+ R+ L T+S + + EA+ +L+ + Sbjct: 37 RLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPHV 96 Query: 326 VQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 V ++ + V + G L + G L P+ V + QI S + Sbjct: 97 VPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQGP-LAPPRAVAIVRQIGSALDAAHAAGA 155 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445 HRD++ NILV + + DFG+A D + T + + APE T + Sbjct: 156 THRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESHATYR 215 Query: 446 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP--PECPESLHDLMCQCWR 503 +D+++ +L E T G PY G + + + P P P + ++ + Sbjct: 216 ADIYALTCVLYECLT-GSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFDAVIARGMA 274 Query: 504 KEPEER 509 K PE+R Sbjct: 275 KNPEDR 280 >3FXW-A nrPDB Length = 336 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 45/187 (24%), Positives = 78/187 (41%), Gaps = 16/187 (8%) Query: 337 IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANIL 396 + I+ E M G L ++ + + ++ I + + ++ N HRD++ N+L Sbjct: 101 LLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLL 160 Query: 397 VG---ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 453 ++ V K+ DFG A+ N A Q + + APE ++ D+WS G+ Sbjct: 161 YTSKEKDAVLKLTDFGFAKETTQN---ALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV 217 Query: 454 LLTEL--------TTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKE 505 ++ L + G+ PGM R L Q G+ P E E L+ + + Sbjct: 218 IMYILLCGFPPFYSNTGQAISPGMKRRIRLGQY--GFPNPEWSEVSEDAKQLIRLLLKTD 275 Query: 506 PEERPTF 512 P ER T Sbjct: 276 PTERLTI 282 >2LQW-A nrPDB Length = 303 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 34/93 (36%), Positives = 50/93 (53%), Gaps = 8/93 (8%) Query: 144 DSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVK 203 DS WY G ++R+E++ L + G FLVR+S T G Y LSVS +N++ V Sbjct: 7 DSSDRSAWYMGPVSRQEAQTRLQGQRH--GMFLVRDSSTCPGDYVLSVS--ENSR---VS 59 Query: 204 HYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKH 236 HY I L + F I + +F+ L L+ +Y H Sbjct: 60 HYIINSLPNRRFKIGDQ-EFDHLPALLEFYKIH 91 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 22/49 (44%), Positives = 26/49 (53%), Gaps = 1/49 (2%) Query: 92 LYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 LYD+ DL FKKGE L I+ E WW A + G+ G IP YV Sbjct: 131 LYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARN-KDGRVGMIPVPYV 178 >5UNP-A nrPDB Length = 369 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 62/234 (26%), Positives = 92/234 (39%), Gaps = 36/234 (15%) Query: 276 LGQGCFGEV--WMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK------LVQ 327 LG+G FG V + G RVA+K +K EA E V++K+ + VQ Sbjct: 42 LGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQ 101 Query: 328 LYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP--QLVDMAAQIASGMAYVERMNY 385 ++ ++ + S DFLK YL P Q+ MA Q+ + ++ Sbjct: 102 MFDWFDYHGHMCISFELLGLSTFDFLKD--NNYLPYPIHQVRHMAFQLCQAVKFLHDNKL 159 Query: 386 VHRDLRAANIL-------VGENL------------VCKVADFGLARLIEDNEYTARQGAK 426 H DL+ NIL + NL +V DFG A ++ T Sbjct: 160 THTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRH 219 Query: 427 FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480 + APE L ++ DVWS G ++ E G + NRE L +ER Sbjct: 220 Y----RAPEVILELGWSQPCDVWSIGCIIFEYYV-GFTLFQTHDNREHLAMMER 268 >5VC6-A nrPDB Length = 289 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 61/262 (23%), Positives = 115/262 (43%), Gaps = 31/262 (11%) Query: 275 KLGQGCFGEVW--MGTWNGTTRVAIKTLKP--GTMSPEAFLQEAQVMKKL-RHEKLVQLY 329 K+G G FG V+ + +G ++ KP G++ + L+E L +H +V+ + Sbjct: 18 KIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYF 77 Query: 330 AVVSEEP-IYIVTEYMSKGSLLDFLKGE--TGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 + +E+ + I EY + GSL D + Y + +L D+ Q+ G+ Y+ M+ V Sbjct: 78 SAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLV 137 Query: 387 HRDLRAANILVGENLVCKVAD--------------FGLARLIEDNEYTARQGAKFPIKWT 432 H D++ +NI + + A F + L ++ Q + ++ Sbjct: 138 HMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDSRFL 197 Query: 433 APEAALYGRFTI--KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC 490 A E L +T K+D+ F + LT + G P P N + ++ +G R+P P+ Sbjct: 198 ANE-VLQENYTHLPKADI--FALALTVVCAAGAEPLPR--NGDQWHEIRQG-RLPRIPQV 251 Query: 491 -PESLHDLMCQCWRKEPEERPT 511 + +L+ +PE RP+ Sbjct: 252 LSQEFTELLKVMIHPDPERRPS 273 >3KA0-A nrPDB Length = 320 Score = 52.8 bits (125), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 44/189 (23%), Positives = 77/189 (40%), Gaps = 19/189 (10%) Query: 337 IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANIL 396 + IV E + G L ++ + + ++ I + Y+ +N HRD++ N+L Sbjct: 88 LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 147 Query: 397 VGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 453 N + K+ DFG A+ E + + + + APE ++ D+WS G+ Sbjct: 148 YTSKRPNAILKLTDFGFAK--ETTSHNSLTEPCYTPYYVAPEVLGPEKYDKSCDMWSLGV 205 Query: 454 LLTEL--------TTKGRVPYPGMVNREVLDQVERGYRMPCP--PECPESLHDLMCQCWR 503 ++ L + G PGM R + Q Y P P E E + L+ + Sbjct: 206 IMYILLCGYPPFYSNHGLAISPGMKTRIRMGQ----YEFPNPEWSEVSEEVKMLIRNLLK 261 Query: 504 KEPEERPTF 512 EP +R T Sbjct: 262 TEPTQRMTI 270 >2AUG-A nrPDB Length = 126 Score = 52.4 bits (124), Expect = 5e-07, Method: Composition-based stats. Identities = 33/106 (31%), Positives = 56/106 (52%), Gaps = 9/106 (8%) Query: 147 QAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYK 206 +++ W+ KI+R E++RL++ G FLVR+S++ + LS+S G +KH++ Sbjct: 24 RSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMS-----HGQKIKHFQ 78 Query: 207 IRKL-DSGGFYIT---SRTQFNSLQQLVAYYSKHADGLCHRLTTVC 248 I + D G + T T+F L QLV +Y + L +L C Sbjct: 79 IIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYC 124 >2ZMD-A nrPDB Length = 390 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 52/238 (21%), Positives = 113/238 (47%), Gaps = 44/238 (18%) Query: 308 EAFLQEAQVMKKLRH--EKLVQLYAV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP 364 +++ E + KL+ +K+++LY ++++ IY+V E G++ + +L+ Sbjct: 99 DSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMEC---GNI------DLNSWLKKK 149 Query: 365 QLVD------MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DN 417 + +D + + + + VH DL+ AN L+ + ++ K+ DFG+A ++ D Sbjct: 150 KSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGML-KLIDFGIANQMQPDT 208 Query: 418 EYTARQGAKFPIKWTAPEA-----------ALYGRFTIKSDVWSFGILLTELTTKGRVPY 466 + + + PEA + + KSDVWS G +L +T G+ P+ Sbjct: 209 TSVVKDSQVGAVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GKTPF 267 Query: 467 PGMVNREVLDQVERGYRMPCP------PECPE-SLHDLMCQCWRKEPEERPTFEYLQA 517 +++++Q+ + + + P P+ PE L D++ C +++P++R + L A Sbjct: 268 -----QQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLA 320 >3A8W-A nrPDB Length = 345 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 57/251 (22%), Positives = 111/251 (44%), Gaps = 23/251 (9%) Query: 276 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEAFLQEAQVMKKL-----RHEKLVQLY 329 +G+G + +V + T R+ A+K +K ++ + + Q K + H LV L+ Sbjct: 17 IGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHPFLVGLH 76 Query: 330 AVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQ--LVDMAAQIASGMAYVERMNYV 386 + +E ++ V EY++ G L+ ++ + +LP+ +A+I+ + Y+ + Sbjct: 77 SCFQTESRLFFVIEYVNGGDLMFHMQRQR----KLPEEHARFYSAEISLALNYLHERGII 132 Query: 387 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 446 +RDL+ N+L+ K+ D+G+ + T P + APE + Sbjct: 133 YRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTP-NYIAPEILRGEDYGFSV 191 Query: 447 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE----CPESLH----DLM 498 D W+ G+L+ E+ GR P+ + + + DQ Y E P SL ++ Sbjct: 192 DWWALGVLMFEMMA-GRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVL 250 Query: 499 CQCWRKEPEER 509 K+P+ER Sbjct: 251 KSFLNKDPKER 261 >5WAX-A nrPDB Length = 310 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 66/273 (24%), Positives = 110/273 (40%), Gaps = 44/273 (16%) Query: 261 DAWEIPRESLRLEVKLGQGCFGEV-WMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKK 319 D +E+ R+ +G G FG M VA+K ++ G E +E + Sbjct: 11 DRYELVRD-------IGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINHRS 63 Query: 320 LRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLD-------FLKGETGKYLRLPQLVDMAA 371 LRH +++ V+ + + IV EY S G L + F + E + + Sbjct: 64 LRHPNIIRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ--------- 114 Query: 372 QIASGMAYVERMNYVHRDLRAANILVGENLV--CKVADFGLARLIEDNEYTARQGAKFPI 429 Q+ SG++Y M HRDL+ N L+ + K+ DFG ++ ++ + Sbjct: 115 QLISGVSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSK--SSVLHSQPKSTVGTP 172 Query: 430 KWTAPEAALYGRFTIK-SDVWSFGILLTELTTKGRVPY-----PGMVNREVLDQVERGYR 483 + APE L + K +DVWS G+ L + G P+ P + + + Y Sbjct: 173 AYIAPEVLLKKEYDGKVADVWSCGVTLYVMLV-GAYPFEDPDEPKNFRKTIQRILGVQYS 231 Query: 484 MP----CPPECPESLHDLMCQCWRKEPEERPTF 512 +P PEC DL+ + + P R T Sbjct: 232 IPDYVHISPEC----QDLISRIFVANPATRITI 260 >5UV4-A nrPDB Length = 311 Score = 52.4 bits (124), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 52/199 (26%), Positives = 95/199 (47%), Gaps = 17/199 (8%) Query: 276 LGQGCFGEVWMGTWNGTTRVAIKTLKPG-TMSPEAFLQEAQVMKKLRHEKLVQL---YAV 331 +G+ C G + T + + +K LK G S + F +E + + +RH LV L Y Sbjct: 33 IGRSCHGTSYKATLDNGYMLTVKWLKEGFAKSKKEFSREIKKLGSVRHPNLVPLRGYYWG 92 Query: 332 VSEEPIYIVTEYMSKGSLLDFLKGETGKYL---RLPQLVDMAAQIASGMAYVERMNYV-H 387 E ++++Y SL +L + L Q +++A IA + Y+ + H Sbjct: 93 PKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHNERVIPH 152 Query: 388 RDLRAANILVGENL-VCKVADFGLARL---IEDNEYTARQGAKFPIKWTAPEAALYGRF- 442 +++++N+L+ + V D+ L RL I E GA + ++ PE + + Sbjct: 153 GNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGA---LGYSPPEFSSTSKPC 209 Query: 443 -TIKSDVWSFGILLTELTT 460 ++KSDV++FG++L EL T Sbjct: 210 PSLKSDVYAFGVILLELLT 228 >5ZTN-A nrPDB Length = 429 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 49/195 (25%), Positives = 86/195 (44%), Gaps = 15/195 (7%) Query: 276 LGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS- 333 +G+G FG+V + + VA+K ++ +E ++++ LR + V+ Sbjct: 105 IGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHM 164 Query: 334 ------EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 I + E +S +L + +K + LP + A I + + + +H Sbjct: 165 LENFTFRNHICMTFELLSM-NLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIH 223 Query: 388 RDLRAANILVGEN--LVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445 DL+ NIL+ + KV DFG + YT Q ++F + APE L R+ + Sbjct: 224 CDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQ-SRF---YRAPEVILGARYGMP 279 Query: 446 SDVWSFGILLTELTT 460 D+WS G +L EL T Sbjct: 280 IDMWSLGCILAELLT 294 >3PG1-A nrPDB Length = 362 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 92/207 (44%), Gaps = 27/207 (13%) Query: 276 LGQGCFGEVWMGTWNGTTRVAIK----TLKPG---TMSPEAFL-----QEAQVMKKLRHE 323 + G +G V G + VAIK T+ G + ++FL +E +++ H Sbjct: 30 ISSGSYGAVCAGVDSEGIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRLLNHFHHP 89 Query: 324 KLVQLYAVVS--EEP----IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD-MAAQIASG 376 ++ L + EEP +Y+VTE M + L + + + + PQ + I G Sbjct: 90 NILGLRDIFVHFEEPAMHKLYLVTELM-RTDLAQVIHDQ--RIVISPQHIQYFMYHILLG 146 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKW-TAPE 435 + + VHRDL NIL+ +N + DF LAR ++ A + +W APE Sbjct: 147 LHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAR---EDTADANKTHYVTHRWYRAPE 203 Query: 436 AAL-YGRFTIKSDVWSFGILLTELTTK 461 + + FT D+WS G ++ E+ + Sbjct: 204 LVMQFKGFTKLVDMWSAGCVMAEMFNR 230 >3HMP-A nrPDB Length = 342 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 52/238 (21%), Positives = 113/238 (47%), Gaps = 44/238 (18%) Query: 308 EAFLQEAQVMKKLRH--EKLVQLYAV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP 364 +++ E + KL+ +K+++LY ++++ IY+V M G++ + +L+ Sbjct: 99 DSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMV---MECGNI------DLNSWLKKK 149 Query: 365 QLVD------MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DN 417 + +D + + + + VH DL+ AN L+ + ++ K+ DFG+A ++ D Sbjct: 150 KSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGML-KLIDFGIANQMQPDT 208 Query: 418 EYTARQGAKFPIKWTAPEA-----------ALYGRFTIKSDVWSFGILLTELTTKGRVPY 466 + + + PEA + + KSDVWS G +L +T G+ P+ Sbjct: 209 TSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GKTPF 267 Query: 467 PGMVNREVLDQVERGYRMPCP------PECPE-SLHDLMCQCWRKEPEERPTFEYLQA 517 +++++Q+ + + + P P+ PE L D++ C +++P++R + L A Sbjct: 268 -----QQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLA 320 >2CMW-A nrPDB Length = 310 Score = 51.6 bits (122), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 68/277 (24%), Positives = 120/277 (43%), Gaps = 26/277 (9%) Query: 269 SLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRH--EKL 325 S+R+ K+G G FGE+ +G T VAIK + +P+ L E + K+L E L Sbjct: 1 SMRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHL-EYRFYKQLGSAGEGL 59 Query: 326 VQLYAV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN 384 Q+Y + +V E + G L+ L + L ++ +A Q+ S M YV N Sbjct: 60 PQVYYFGPCGKYNAMVLELL--GPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKN 117 Query: 385 YVHRDLRAANILVG-----ENLVCKVADFGLARLIEDNE------YTARQGAKFPIKWTA 433 ++RD++ N L+G + V + DFGLA+ D E Y + ++ + Sbjct: 118 LIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMS 177 Query: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER----GYRMPCPPE 489 L + + D+ + G + +G +P+ G+ + ++ ++ P Sbjct: 178 INTHLGKEQSRRDDLEALGHMFMYF-LRGSLPWQGLKADTLKERYQKIGDTKRNTPIEAL 236 Query: 490 C---PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 C PE + + R + E+P +EYL+ D F Sbjct: 237 CENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLF 273 >6GVJ-A nrPDB Length = 429 Score = 51.6 bits (122), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 52/238 (21%), Positives = 113/238 (47%), Gaps = 44/238 (18%) Query: 308 EAFLQEAQVMKKLRH--EKLVQLYAV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP 364 +++ E + KL+ +K+++LY ++++ IY+V M G++ + +L+ Sbjct: 187 DSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMV---MECGNI------DLNSWLKKK 237 Query: 365 QLVD------MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DN 417 + +D + + + + VH DL+ AN L+ + ++ K+ DFG+A ++ D Sbjct: 238 KSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGML-KLIDFGIANQMQPDT 296 Query: 418 EYTARQGAKFPIKWTAPEA-----------ALYGRFTIKSDVWSFGILLTELTTKGRVPY 466 + + + PEA + + KSDVWS G +L +T G+ P+ Sbjct: 297 TSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GKTPF 355 Query: 467 PGMVNREVLDQVERGYRMPCP------PECPE-SLHDLMCQCWRKEPEERPTFEYLQA 517 +++++Q+ + + + P P+ PE L D++ C +++P++R + L A Sbjct: 356 -----QQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLA 408 >3JV3-A nrPDB Length = 283 Score = 51.6 bits (122), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 22/68 (32%), Positives = 39/68 (57%), Gaps = 3/68 (4%) Query: 85 GVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVA-PS 143 G + +YDY ++ + +L+F KG+ + ++N + DWW +GQ G PSNYV + Sbjct: 1 GSCQVIGMYDYTAQNDDELAFSKGQIINVLNKEDPDWWKGE--VSGQVGLFPSNYVKLTT 58 Query: 144 DSIQAEEW 151 D +++W Sbjct: 59 DMDPSQQW 66 >2EKX-A nrPDB Length = 110 Score = 51.6 bits (122), Expect = 8e-07, Method: Composition-based stats. Identities = 32/103 (31%), Positives = 52/103 (50%), Gaps = 3/103 (2%) Query: 143 SDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSV-SDFDNAKGLN 201 S + +W+ G I+R +SE+LL + G F+VR S G Y +S+ S N K Sbjct: 5 SSGLDDYDWFAGNISRSQSEQLL-RQKGKEGAFMVRNSSQV-GMYTVSLFSKAVNDKKGT 62 Query: 202 VKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL 244 VKHY + Y+ F+S+ +L+ Y+ ++ G+ RL Sbjct: 63 VKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRL 105 >5J0A-A nrPDB Length = 300 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 53/240 (22%), Positives = 116/240 (48%), Gaps = 31/240 (12%) Query: 310 FLQEAQVMKKLRHEKLV--QLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP--- 364 + EA+++K L H +V + + ++ + + EY + SL D ++ E K + P Sbjct: 61 LMDEAKILKSLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIE-ERYKASQDPFPA 119 Query: 365 -QLVDMAAQIASGMAYV-ERMNYVHRDLRAANILV-GENLVCKVADFGLARLIEDN-EYT 420 ++ +A +A G+ Y+ + +H D++++N+++ G+ K+ D G++ +++N E T Sbjct: 120 AIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVT 179 Query: 421 ARQGAKFPIKWTAPEAAL--YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVN-----RE 473 + + P+ A+ G T K+D+++FG+ L E+ T +P+ + N + Sbjct: 180 DPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLS-IPHINLSNDDDDEDK 238 Query: 474 VLDQVE---------RGYRMPCP----PECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 D+ + G R P E + + +L C ++P++RP+ ++ LE Sbjct: 239 TFDESDFDDEAYYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEALE 298 >2WO6-A nrPDB Length = 382 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 51/202 (25%), Positives = 99/202 (49%), Gaps = 27/202 (13%) Query: 276 LGQGCFGEVWMGTWNGTTR--VAIKTLKPGTMSPEAFLQEAQVMKKL-----RHEKLVQL 328 +G+G FG+V + ++ + VAIK +K + +AFL +AQ+ +L +H+ ++ Sbjct: 62 IGKGSFGQV-VKAYDRVEQEWVAIKIIK----NKKAFLNQAQIEVRLLELMNKHDTEMKY 116 Query: 329 YAV------VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE- 381 Y V + + +V E +S +L D L+ + + L A Q+ + + ++ Sbjct: 117 YIVHLKRHFMFRNHLCLVFEMLSY-NLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT 175 Query: 382 -RMNYVHRDLRAANILVG--ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438 ++ +H DL+ NIL+ + K+ DFG + + Y Q ++F + +PE L Sbjct: 176 PELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQ-SRF---YRSPEVLL 231 Query: 439 YGRFTIKSDVWSFGILLTELTT 460 + + D+WS G +L E+ T Sbjct: 232 GMPYDLAIDMWSLGCILVEMHT 253 >3HAJ-A nrPDB Length = 486 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 36/137 (26%), Positives = 60/137 (43%), Gaps = 5/137 (3%) Query: 6 SKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFG 65 S P ++Q + S P E+ G T +K S+ + ++ ++ + Sbjct: 349 SNPAQSAQSQSSYNPFEDEDDTGSTVSEKDDTKAKNVSS---YEKTQSYPTDWSDDESNN 405 Query: 66 GFNSSDTV--TSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWL 123 F+S+D ++P +G ALYDYE + +LSFK G+ L + + + W Sbjct: 406 PFSSTDANGDSNPFDDDATSGTEVRVRALYDYEGQEHDELSFKAGDELTKMEDEDEQGWC 465 Query: 124 AHSLSTGQTGYIPSNYV 140 L GQ G P+NYV Sbjct: 466 KGRLDNGQVGLYPANYV 482 >4LFI-A nrPDB Length = 374 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 45/189 (23%), Positives = 86/189 (45%), Gaps = 36/189 (19%) Query: 312 QEAQVMKKLR----------HEKLVQLYAVVSEEPIY----IVTEYMSKGSLLDFLKGET 357 Q+ V+K +R H ++ L+ ++ ++PI +V EY+ +DF Sbjct: 112 QKEDVLKFIRPYIFDQPHNGHANIIHLFDII-KDPISKTPALVFEYVDN---VDFR---- 163 Query: 358 GKYLRLPQLVDMAA-----QIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLA 411 + P+L D+ ++ + Y M +HRD++ N+++ +N ++ D+GLA Sbjct: 164 ---ILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLA 220 Query: 412 RLIEDN-EYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGM 469 N EY R ++F + PE + Y + D+WSFG +L + K + G Sbjct: 221 EFYHVNMEYNVRVASRF---FKGPELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGT 277 Query: 470 VNREVLDQV 478 N + L ++ Sbjct: 278 SNTDQLVKI 286 >4H1O-A nrPDB Length = 560 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 42/127 (33%), Positives = 62/127 (48%), Gaps = 21/127 (16%) Query: 136 PSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFD 195 P N P+ +E W+ G ++ +E+E+LL + G+FLVRES++ G + LSV D Sbjct: 122 PLNCADPT----SERWFHGHLSGKEAEKLL-TEKGKHGSFLVRESQSHPGDFVLSVRTGD 176 Query: 196 NAKGLN-----VKHYKIR----KLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTT 246 + N V H IR K D GG +F+SL LV +Y K+ + L T Sbjct: 177 DKGESNDGKSKVTHVMIRCQELKYDVGG-----GERFDSLTDLVEHYKKNP--MVETLGT 229 Query: 247 VCPTSKP 253 V +P Sbjct: 230 VLQLKQP 236 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 32/96 (33%), Positives = 50/96 (52%), Gaps = 9/96 (9%) Query: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205 + + W+ IT E+E LLL G+FL R S++ G + LSV + V H Sbjct: 22 MTSRRWFHPNITGVEAENLLL-TRGVDGSFLARPSKSNPGDFTLSVR-----RNGAVTHI 75 Query: 206 KIRKLDSGGFY-ITSRTQFNSLQQLVAYYSKHADGL 240 KI+ ++GG+Y + +F +L +LV YY +H L Sbjct: 76 KIQ--NTGGYYDLYGGEKFATLAELVQYYMEHHGQL 109 >3E3P-A nrPDB Length = 360 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 60/212 (28%), Positives = 93/212 (43%), Gaps = 30/212 (14%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLV 326 + ++E GQG FG V +G T VAIK + LQ Q + L H +V Sbjct: 23 DRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNRELQIMQDLAVLHHPNIV 82 Query: 327 QLYAVV------SEEPIY--IVTEYMSKGSLLDFLKGETGKYLRL-----PQLVD--MAA 371 QL + IY +V EY+ D L Y R P L+ + Sbjct: 83 QLQSYFYTLGERDRRDIYLNVVMEYVP-----DTLHRCCRNYYRRQVAPPPILIKVFLFQ 137 Query: 372 QIAS-GMAYVERMNYVHRDLRAANILVGE-NLVCKVADFGLARLIEDNE-YTARQGAKFP 428 I S G ++ +N HRD++ N+LV E + K+ DFG A+ + +E A +++ Sbjct: 138 LIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYICSRY- 196 Query: 429 IKWTAPEAALYG--RFTIKSDVWSFGILLTEL 458 + APE ++G +T D+WS G + E+ Sbjct: 197 --YRAPE-LIFGNQHYTTAVDIWSVGCIFAEM 225 >5AP3-A nrPDB Length = 313 Score = 50.8 bits (120), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 52/238 (21%), Positives = 113/238 (47%), Gaps = 44/238 (18%) Query: 308 EAFLQEAQVMKKLRH--EKLVQLYAV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP 364 +++ E + KL+ +K+++LY ++++ IY+V M G++ + +L+ Sbjct: 71 DSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMV---MECGNI------DLNGWLKKK 121 Query: 365 QLVD------MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DN 417 + +D + + + + VH DL+ AN L+ + ++ K+ DFG+A ++ D Sbjct: 122 KSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGML-KLIDFGIANQMQPDT 180 Query: 418 EYTARQGAKFPIKWTAPEAA-----------LYGRFTIKSDVWSFGILLTELTTKGRVPY 466 + + + PEA + + KSDVWS G +L +T G+ P+ Sbjct: 181 TSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTY-GKTPF 239 Query: 467 PGMVNREVLDQVERGYRMPCP------PECPE-SLHDLMCQCWRKEPEERPTFEYLQA 517 +++++Q+ + + + P P+ PE L D++ C +++P++R + L A Sbjct: 240 -----QQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLA 292 >4BNE-A nrPDB Length = 457 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 23/52 (44%), Positives = 30/52 (57%) Query: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAP 142 ALYDYE + + +LSFK G+ L + N + W L GQ G P+NYV P Sbjct: 404 ALYDYEGQEQDELSFKAGDELTKMENEDEQGWCKGRLDNGQVGLYPANYVEP 455 >2EOB-A nrPDB Length = 124 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 33/92 (35%), Positives = 55/92 (59%), Gaps = 10/92 (10%) Query: 147 QAEEWYFGKITRRESERLLLNAENPR-GTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205 +++ WY+ +++R E+E +L+ PR G FL+R+ E T +Y ++ A+G VKH Sbjct: 17 ESKPWYYDRLSRGEAEDMLMRI--PRDGAFLIRKREGTD-SYAITF----RARG-KVKHC 68 Query: 206 KIRKLDSGGFYITSRTQFNSLQQLVAYYSKHA 237 +I + D F + + F SL +LV+YY KHA Sbjct: 69 RINR-DGRHFVLGTSAYFESLVELVSYYEKHA 99 >6CMQ-A nrPDB Length = 427 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 39/115 (33%), Positives = 58/115 (50%), Gaps = 17/115 (14%) Query: 148 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLN-----V 202 +E W+ G ++ +E+E+LL + G+FLVRES++ G + LSV D+ N V Sbjct: 7 SERWFHGHLSGKEAEKLL-TEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKV 65 Query: 203 KHYKIR----KLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKP 253 H IR K D GG +F+SL LV +Y K+ + L TV +P Sbjct: 66 THVMIRCQELKYDVGGG-----ERFDSLTDLVEHYKKNP--MVETLGTVLQLKQP 113 >1GCQ-A nrPDB Length = 61 Score = 50.1 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 20/58 (34%), Positives = 36/58 (62%), Gaps = 2/58 (3%) Query: 85 GVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAP 142 G T AL+D++ + + +L F++G+ + +++N++ +WW GQTG P NYV P Sbjct: 1 GSTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWW--KGACHGQTGMFPRNYVTP 56 >6FYV-A nrPDB Length = 337 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 84/210 (40%), Gaps = 33/210 (15%) Query: 276 LGQGCFGEVWMGTWNGT--TRVAIKTLKPGTMSPEAFLQEAQVMKKLRHE------KLVQ 327 LG+G FG+V +G VA+K +K EA E QV++ L + VQ Sbjct: 22 LGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQ 81 Query: 328 LYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 + + IV E + S DF+K + ++ + MA QI + ++ Sbjct: 82 MLEWFDHHGHVCIVFELLGL-STYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLT 140 Query: 387 HRDLRAANILVG-------------------ENLVCKVADFGLARLIEDNEYTARQGAKF 427 H DL+ NIL +N KV DFG A +D ++ + Sbjct: 141 HTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATY-DDEHHSTLVSTR- 198 Query: 428 PIKWTAPEAALYGRFTIKSDVWSFGILLTE 457 + APE L ++ DVWS G +L E Sbjct: 199 --HYRAPEVILALGWSQPCDVWSIGCILIE 226 >2JD5-A nrPDB Length = 373 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 47/209 (22%), Positives = 94/209 (44%), Gaps = 27/209 (12%) Query: 275 KLGQGCFGEVWMG-TWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS 333 KLG G F VW+ T VA+K ++ + EA E ++++++ + ++ + Sbjct: 26 KLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTKEDSMGA 85 Query: 334 EEPIYIVTEYMSKG---------------SLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378 + ++ + KG +LL +K + + L + ++ Q+ G+ Sbjct: 86 NHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLIYVKQISKQLLLGLD 145 Query: 379 YVER-MNYVHRDLRAANILVG-----ENLV-CKVADFGLARLIEDNEYTARQGAKFPIKW 431 Y+ R +H D++ N+L+ ENL+ K+AD G A +++ + Q ++ Sbjct: 146 YMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHYTNSIQTREY---- 201 Query: 432 TAPEAALYGRFTIKSDVWSFGILLTELTT 460 +PE L + +D+WS L+ EL T Sbjct: 202 RSPEVLLGAPWGCGADIWSTACLIFELIT 230 >3UC3-A nrPDB Length = 361 Score = 50.1 bits (118), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 50/192 (26%), Positives = 83/192 (43%), Gaps = 23/192 (11%) Query: 276 LGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVV-S 333 +G G FG + T VA+K ++ G E +E + LRH +V+ V+ + Sbjct: 28 IGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQREIINHRSLRHPNIVRFKEVILT 87 Query: 334 EEPIYIVTEYMSKGSLLD-------FLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 + I+ EY S G L + F + E + + Q+ SG++Y M Sbjct: 88 PTHLAIIMEYASGGELYERICNAGRFSEDEARFFFQ---------QLLSGVSYCHSMQIC 138 Query: 387 HRDLRAANILVGENLV--CKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTI 444 HRDL+ N L+ + K+ DFG ++ ++ + + APE L + Sbjct: 139 HRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLLRQEYDG 196 Query: 445 K-SDVWSFGILL 455 K +DVWS G+ L Sbjct: 197 KIADVWSCGVTL 208 >3QD2-B nrPDB Length = 332 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 29/101 (28%), Positives = 49/101 (48%), Gaps = 17/101 (16%) Query: 372 QIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE------------- 418 QIA + ++ +HRDL+ +NI + V KV DFGL ++ +E Sbjct: 172 QIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYA 231 Query: 419 -YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTEL 458 +T + G K + +PE ++ K D++S G++L EL Sbjct: 232 THTGQVGTKL---YMSPEQIHGNNYSHKVDIFSLGLILFEL 269 >1MIL-A nrPDB Length = 104 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 33/89 (37%), Positives = 47/89 (52%), Gaps = 13/89 (14%) Query: 146 IQAEEWYFGKITRRESERLL-LNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKH 204 ++ E W+ GK++RRE+E LL LN G FLVRES TT G Y L+ K L + Sbjct: 4 LRGEPWFHGKLSRREAEALLQLN-----GDFLVRESTTTPGQYVLTGLQSGQPKHLLL-- 56 Query: 205 YKIRKLDSGGFYITSRTQFNSLQQLVAYY 233 +D G T +F S+ L++Y+ Sbjct: 57 -----VDPEGVVRTKDHRFESVSHLISYH 80 >3EHQ-A nrPDB Length = 222 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 25/58 (43%), Positives = 36/58 (62%), Gaps = 2/58 (3%) Query: 84 GGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVA 141 G V F ALY +E RT +L ++G+ + I + ++ +WW S G+TG IPSNYVA Sbjct: 12 GQVKVFRALYTFEPRTPDELYIEEGDIIYITDMSDTNWW--KGTSKGRTGLIPSNYVA 67 >4XHH-A nrPDB Length = 403 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 58/269 (21%), Positives = 107/269 (39%), Gaps = 19/269 (7%) Query: 270 LRLEVKLGQGCFGEVWMGT-WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL 328 R+ K+G G FG+++ GT VAI+ + P+ E++V K L + Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQ-LDYESRVYKYLSGGVGIPF 67 Query: 329 YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 E Y G L+ L + ++ +A Q+ + Y+ +++HR Sbjct: 68 IRWFGREGEYNAMVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICRVQYIHGRSFIHR 127 Query: 389 DLRAANILVG---ENLVCKVADFGLARLIEDNE------YTARQGAKFPIKWTAPEAALY 439 D++ N L+G V DFGL++ D Y + ++ + L Sbjct: 128 DIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTHLG 187 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGM---VNREVLDQV-ERGYRMPCPPEC---PE 492 + + D+ S G +L KG +P+ G+ ++ D++ E+ + C P Sbjct: 188 IEQSRRDDLESLGYMLIYF-CKGSLPWQGLKATTKKQKYDRILEKKLCISVETLCAGLPL 246 Query: 493 SLHDLMCQCWRKEPEERPTFEYLQAFLED 521 + M C + +ERP + YL +D Sbjct: 247 EFSEYMNYCRNLKFDERPDYLYLARLFKD 275 >5AIR-A nrPDB Length = 430 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 57/214 (26%), Positives = 100/214 (46%), Gaps = 37/214 (17%) Query: 276 LGQGCFGEVWMGTW-NGTTRVAIKTLKPGTMSPEAFL-QEAQVMKKLRHEKLVQL-YAVV 332 +G G FG V+ + VAIK + + + F +E Q+M+KL H +V+L Y Sbjct: 72 IGNGSFGVVYQAKLCDSGELVAIKKV----LQDKRFKNRELQIMRKLDHCNIVRLRYFFY 127 Query: 333 S----EEPIYIVTEYMSKGSLLDFLKGETGK----YLRLPQLVDM------AAQIASGMA 378 S ++ +Y+ +LD++ + Y R Q + + Q+ +A Sbjct: 128 SSGEKKDEVYL-------NLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLA 180 Query: 379 YVERMNYVHRDLRAANILVG-ENLVCKVADFGLAR-LIEDNEYTARQGAKFPIKWTAPEA 436 Y+ HRD++ N+L+ + V K+ DFG A+ L+ + +++ + APE Sbjct: 181 YIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRY---YRAPE- 236 Query: 437 ALYG--RFTIKSDVWSFGILLTELTTKGRVPYPG 468 ++G +T DVWS G +L EL G+ +PG Sbjct: 237 LIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPG 269 >3ZUT-A nrPDB Length = 362 Score = 48.5 bits (114), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 54/205 (26%), Positives = 87/205 (42%), Gaps = 25/205 (12%) Query: 265 IPRESLRLEV--KLGQGCFGEV-WMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR 321 I +S R E+ +G G FG M VA+K ++ G E +E + LR Sbjct: 14 IMHDSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLR 73 Query: 322 HEKLVQLYAVV-SEEPIYIVTEYMSKGSLLD-------FLKGETGKYLRLPQLVDMAAQI 373 H +V+ V+ + + IV EY S G L + F + E + + Q+ Sbjct: 74 HPNIVRFKEVILTPTHLAIVMEYASGGELFERICNAGRFSEDEARFFFQ---------QL 124 Query: 374 ASGMAYVERMNYVHRDLRAANILVGENLV--CKVADFGLARLIEDNEYTARQGAKFPIKW 431 SG++Y M HRDL+ N L+ + K+ FG ++ ++ + + Sbjct: 125 ISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSK--SSVLHSQPKSTVGTPAY 182 Query: 432 TAPEAALYGRFTIK-SDVWSFGILL 455 APE L + K +DVWS G+ L Sbjct: 183 IAPEVLLKKEYDGKVADVWSCGVTL 207 >1TKI-A nrPDB Length = 321 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 55/249 (22%), Positives = 108/249 (43%), Gaps = 23/249 (9%) Query: 276 LGQGCFGEVW--MGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY-AVV 332 LG+G FG V + T + T +A K +K +E ++ RH ++ L+ + Sbjct: 13 LGRGEFGIVHRCVETSSKKTYMA-KFVKVKGTDQVLVKKEISILNIARHRNILHLHESFE 71 Query: 333 SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRA 392 S E + ++ E++S + + + + L ++V Q+ + ++ N H D+R Sbjct: 72 SMEELVMIFEFISGLDIFERINTSAFE-LNEREIVSYVHQVCEALQFLHSHNIGHFDIRP 130 Query: 393 ANIL--VGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT-----APEAALYGRFTIK 445 NI+ + K+ +FG AR + + G F + +T APE + + Sbjct: 131 ENIIYQTRRSSTIKIIEFGQARQL-------KPGDNFRLLFTAPEYYAPEVHQHDVVSTA 183 Query: 446 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQV---ERGYRMPCPPECPESLHDLMCQCW 502 +D+WS G L+ L + G P+ N+++++ + E + E D + + Sbjct: 184 TDMWSLGTLVYVLLS-GINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLL 242 Query: 503 RKEPEERPT 511 KE + R T Sbjct: 243 VKERKSRMT 251 >5NP2-A nrPDB Length = 61 Score = 47.8 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 24/55 (43%), Positives = 36/55 (65%), Gaps = 3/55 (5%) Query: 89 FVALYDYESRTETDLSFKKGERLQIVN-NTEGDWWLAHSLSTGQTGYIPSNYVAP 142 FVALYD+ + + LS KGE+L+++ N G+W A + GQ G++PSNY+ P Sbjct: 7 FVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT-KNGQ-GWVPSNYITP 59 >5U06-A nrPDB Length = 120 Score = 46.6 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 33/103 (32%), Positives = 52/103 (50%), Gaps = 10/103 (9%) Query: 136 PSNYVAPSDSIQAEE-WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDF 194 P++ + S +I + W+ G+I+R ES+RL+ G FLVRES+ + LS+ Sbjct: 3 PASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHL 62 Query: 195 DNAKGLNVKHYKI-RKLDSGGFYIT---SRTQFNSLQQLVAYY 233 VKHY I + G Y + +T+F L QLV ++ Sbjct: 63 Q-----KVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFH 100 >2CUC-A nrPDB Length = 70 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 21/54 (38%), Positives = 32/54 (59%) Query: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAP 142 FVAL+ Y + +L +KGE ++++ + W SL TG+TG PS+YV P Sbjct: 10 FVALHTYSAHRPEELDLQKGEGIRVLGKYQDGWLKGLSLLTGRTGIFPSDYVIP 63 >4IDT-A nrPDB Length = 356 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 52/193 (26%), Positives = 83/193 (43%), Gaps = 13/193 (6%) Query: 273 EVKLGQGCFGEVW-MGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAV 331 +++LG+G FGEV M + A+K ++ E + A L ++V LY Sbjct: 79 QLRLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACA----GLTSPRIVPLYGA 134 Query: 332 VSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDL 390 V E P + I E + GSL +K E G L + + Q G+ Y+ +H D+ Sbjct: 135 VREGPWVNIFMELLEGGSLGQLVK-EQG-CLPEDRALYYLGQALEGLEYLHSRRILHGDV 192 Query: 391 RAANILV-GENLVCKVADFGLARLIEDNEYTAR--QGAKFPIKWT--APEAALYGRFTIK 445 +A N+L+ + + DFG A ++ + G P T APE L K Sbjct: 193 KADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDAK 252 Query: 446 SDVWSFGILLTEL 458 DVWS ++ + Sbjct: 253 VDVWSSCCMMLHM 265 >4XHL-A nrPDB Length = 394 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 55/269 (20%), Positives = 107/269 (39%), Gaps = 19/269 (7%) Query: 270 LRLEVKLGQGCFGEVWMGT-WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL 328 R+ K+G G FG+++ GT VAI+ + P+ E++V + L + Sbjct: 9 FRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQ-LDYESRVYRYLSGGVGIPF 67 Query: 329 YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 E Y G L+ L + ++ +A Q+ + Y+ +++HR Sbjct: 68 IRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGRSFIHR 127 Query: 389 DLRAANILVG---ENLVCKVADFGLARLIEDNE------YTARQGAKFPIKWTAPEAALY 439 D++ N L+G V DFGL++ D Y + ++ + L Sbjct: 128 DIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTHLG 187 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGM---VNREVLDQV-ERGYRMPCPPEC---PE 492 + + D+ S G +L KG +P+ G+ ++ D++ E+ + C P Sbjct: 188 IEQSRRDDLESLGYVLIYF-CKGSLPWQGLKATTKKQKYDRIMEKKLNVSVETLCSGLPL 246 Query: 493 SLHDLMCQCWRKEPEERPTFEYLQAFLED 521 + M C + +E+P + +L +D Sbjct: 247 EFQEYMAYCKNLKFDEKPDYLFLARLFKD 275 >2CRH-A nrPDB Length = 138 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 32/125 (25%), Positives = 58/125 (46%), Gaps = 11/125 (8%) Query: 139 YVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 198 + P + WY G + R +E +L N + GTFLVR+ + +S+ Sbjct: 16 WEGPPQDLSVHLWYAGPMERAGAESILANRSD--GTFLVRQRVKDAAEFAISIK-----Y 68 Query: 199 GLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHR---LTTVCPTSKPQT 255 + VKH KI + G + IT + F L +LV +Y +++ C + T P +P+ Sbjct: 69 NVEVKHIKIMTAE-GLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEK 127 Query: 256 QGLAK 260 + +++ Sbjct: 128 RTISR 132 >2EYZ-A nrPDB Length = 304 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 27/64 (42%), Positives = 40/64 (62%), Gaps = 7/64 (10%) Query: 144 DSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVK 203 DS + WY+G+++R+E+ LL + G FLVR+S T+ G Y LSVS +N++ V Sbjct: 6 DSEERSSWYWGRLSRQEAVALLQGQRH--GVFLVRDSSTSPGDYVLSVS--ENSR---VS 58 Query: 204 HYKI 207 HY I Sbjct: 59 HYII 62 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 23/50 (46%), Positives = 29/50 (58%), Gaps = 1/50 (2%) Query: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 AL+D+ E DL FKKG+ L+I + E WW A S G+ G IP YV Sbjct: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAED-SEGKRGMIPVPYV 187 >1UHF-A nrPDB Length = 69 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 25/58 (43%), Positives = 35/58 (60%), Gaps = 5/58 (8%) Query: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTG-QTGYIPSNYVAPSDS 145 ++ALY Y S DL+F +GE + +V +G+WW S G ++G PSNYV P DS Sbjct: 11 YIALYPYSSVEPGDLTFTEGEEI-LVTQKDGEWWTG---SIGDRSGIFPSNYVKPKDS 64 >4Y12-A nrPDB Length = 375 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 40/151 (26%), Positives = 71/151 (47%), Gaps = 17/151 (11%) Query: 315 QVMKKLRHEKLVQLYAVVSE-----EPI-YIVTEYMSKGSLLDFLKGETGKYLRLPQLVD 368 Q + ++ H +VQ++ V +P+ YIV EY+ SL K G+ L + + + Sbjct: 170 QFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL----KRSKGQKLPVAEAIA 225 Query: 369 MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFP 428 +I ++Y+ + V+ DL+ NI++ E + K+ D G I N + G Sbjct: 226 YLLEILPALSYLHSIGLVYNDLKPENIMLTEEQL-KLIDLGAVSRI--NSFGYLYGTP-- 280 Query: 429 IKWTAPEAALYGRFTIKSDVWSFGILLTELT 459 + APE G T+ +D+++ G L LT Sbjct: 281 -GFQAPEIVRTGP-TVATDIYTVGRTLAALT 309 >5X1R-A nrPDB Length = 302 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 61/281 (21%), Positives = 117/281 (41%), Gaps = 37/281 (13%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP--------------------- 307 ++ +G+G FG V+ + R +AIK P +++ Sbjct: 23 FEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQAG 82 Query: 308 -EAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQ 365 +F+QEA+++ + H L+ + E Y+ T++ S G+ L L+ + + + Sbjct: 83 LNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYS-GTTLKNLQAQQPEKIDEAW 141 Query: 366 LVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR-----LIEDNEYT 420 + + + S + + + Y+HRD+ NI + E+ + + DFG AR L ++ E Sbjct: 142 IRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDETEIV 201 Query: 421 ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480 + G ++T G +T D+++ G +L L P P V R + D + Sbjct: 202 LKPGFAPIEQYTENSDGEQGPWT---DIYALGAVLHTLIVGS--PPPVSVVRSIEDSYQP 256 Query: 481 GYRMPCPPECPESLHDLMCQCWRKEPEERP-TFEYLQAFLE 520 PE L + + +PE+RP T + + LE Sbjct: 257 LTERRPAGYSPELLRT-VDRALALKPEDRPQTIDEMAELLE 296 >2V1Q-A nrPDB Length = 60 Score = 45.1 bits (105), Expect = 9e-05, Method: Composition-based stats. Identities = 14/59 (23%), Positives = 38/59 (64%), Gaps = 1/59 (1%) Query: 85 GVTTFVALYDYESRTETDLSFKKGERLQIVNNTEG-DWWLAHSLSTGQTGYIPSNYVAP 142 G+ + YD+ + ++ +L+ K G+++ I+++ + DWW+ + +G++G +P+ ++ P Sbjct: 1 GMERGIVQYDFMAESQDELTIKSGDKVYILDDKKSKDWWMCQLVDSGKSGLVPAQFIEP 59 >5GZA-A nrPDB Length = 290 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 67/280 (23%), Positives = 111/280 (39%), Gaps = 29/280 (10%) Query: 267 RESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLV 326 R +R +GQG +V++ W G +VA+ L + + FL +++ L+ +V Sbjct: 24 RSGVRRVKLIGQGAVKKVYLSEWQG-QKVALSVLSSDQYADD-FLHGLSMLRALQSSHVV 81 Query: 327 QLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 L V E+ ++ VTEY GS+L + R Q+A + YV + Y+ Sbjct: 82 TLVGVCEEDAVF-VTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLA--IDYVAFLAYL 138 Query: 387 HRDLRAANILVGENLVCK-VADFGLA---RLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 H ++ N + K ++ F LA RL+ ++ + K + L G F Sbjct: 139 HSSPAGIRVMCDSNDLHKTLSQFLLASDMRLLANDLDALPEVEKGGLGVKCGHHELTGDF 198 Query: 443 TIKSDVWSFGILLT----------ELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE 492 +W +G + E T ++P V R +L V G + Sbjct: 199 VAPEQLWPYGEDFSFSDEAMPGYDEKTDIWKIP---DVTRFLLGDVLGGDVIHF------ 249 Query: 493 SLHDLMCQCWRKEPEERPTF-EYLQAFLEDYFTSTEPQYQ 531 L + +C RKE RPT E L + Y + E Q Q Sbjct: 250 HLFQIYSECKRKEAHMRPTAREVLSVYRSVYDSMMESQSQ 289 >2PLE-A nrPDB Length = 105 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 29/91 (31%), Positives = 52/91 (57%), Gaps = 11/91 (12%) Query: 147 QAEEWYFGKITRRESERLLLNAENPR-GTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205 +++EWY +TR ++E +L+ PR G FLVR+ +Y +S A+G +KH Sbjct: 7 ESKEWYHASLTRAQAEHMLMRV--PRDGAFLVRK-RNEPNSYAISF----RAEG-KIKHC 58 Query: 206 KIRKLDSGGFYITSRTQFNSLQQLVAYYSKH 236 ++++ G + ++F+SL L++YY KH Sbjct: 59 RVQQ--EGQTVMLGNSEFDSLVDLISYYEKH 87 >6F55-A nrPDB Length = 67 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 21/50 (42%), Positives = 27/50 (54%) Query: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 ALYDY + +LSFK GE L ++ + W L TG G P+NYV Sbjct: 10 ALYDYTGQEADELSFKAGEELMKISEEDEQGWCKGRLLTGHVGLYPANYV 59 >2PZI-A nrPDB Length = 681 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 40/151 (26%), Positives = 71/151 (47%), Gaps = 17/151 (11%) Query: 315 QVMKKLRHEKLVQLYAVVSE-----EPI-YIVTEYMSKGSLLDFLKGETGKYLRLPQLVD 368 Q + ++ H +VQ++ V +P+ YIV EY+ SL K G+ L + + + Sbjct: 131 QFLAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL----KRSKGQKLPVAEAIA 186 Query: 369 MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFP 428 +I ++Y+ + V+ DL+ NI++ E + K+ D G I N + G Sbjct: 187 YLLEILPALSYLHSIGLVYNDLKPENIMLTEEQL-KLIDLGAVSRI--NSFGYLYGTP-- 241 Query: 429 IKWTAPEAALYGRFTIKSDVWSFGILLTELT 459 + APE G T+ +D+++ G L LT Sbjct: 242 -GFQAPEIVRTGP-TVATDIYTVGRTLAALT 270 >2X3W-D nrPDB Length = 60 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 20/50 (40%), Positives = 29/50 (58%) Query: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 ALYDY+ + + +LSFK G+ L + + W L +GQ G P+NYV Sbjct: 8 ALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYV 57 >6BXI-A nrPDB Length = 333 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 59/273 (21%), Positives = 107/273 (39%), Gaps = 59/273 (21%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEAFLQEAQVMKKLRHEKLV 326 ESL++ +G+G FGEV + T V A+K L+ M L++ QV +R E+ + Sbjct: 9 ESLKV---IGRGAFGEVRLVQKKDTGHVYAMKILRKADM-----LEKEQV-GHIRAERDI 59 Query: 327 -----------QLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIAS 375 Y+ + +Y++ E++ G ++ L + Q A+ Sbjct: 60 LVEADSLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFY--IAETVL 117 Query: 376 GMAYVERMNYVHRDLRAANILVGENLVCKVADFGLA------------------------ 411 + + ++ ++HRD++ N+L+ K++DFGL Sbjct: 118 AIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFT 177 Query: 412 -------RLIEDNEYTARQGAKFPI---KWTAPEAALYGRFTIKSDVWSFGILLTELTTK 461 R E + RQ A + + APE + + D WS G+++ E+ Sbjct: 178 FQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLI- 236 Query: 462 GRVPYPGMVNREVLDQVERGYR-MPCPPECPES 493 G P+ +E +V + PPE P S Sbjct: 237 GYPPFCSETPQETYKKVMNWKETLTFPPEVPIS 269 >2JT4-A nrPDB Length = 71 Score = 43.9 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 13/54 (24%), Positives = 36/54 (66%), Gaps = 1/54 (1%) Query: 90 VALYDYESRTETDLSFKKGERLQIVNNTEG-DWWLAHSLSTGQTGYIPSNYVAP 142 + YD+ + ++ +L+ K G+++ I+++ + DWW+ + +G++G +P+ ++ P Sbjct: 10 IVQYDFMAESQDELTIKSGDKVYILDDKKSKDWWMCQLVDSGKSGLVPAQFIEP 63 >2CUD-A nrPDB Length = 79 Score = 43.9 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 30/71 (42%), Positives = 43/71 (60%), Gaps = 5/71 (7%) Query: 75 SPQRAGPLA---GGVTTFVA-LYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTG 130 S +GPL G + F+A L DY S + F++GE+L+++++ EG WW A SLSTG Sbjct: 2 SSGSSGPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISD-EGGWWKAISLSTG 60 Query: 131 QTGYIPSNYVA 141 + YIP VA Sbjct: 61 RESYIPGICVA 71 >3M42-A nrPDB Length = 299 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 41/189 (21%), Positives = 69/189 (36%), Gaps = 40/189 (21%) Query: 337 IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANIL 396 + IV E + G L ++ + + ++ I + Y+ +N HRD++ N+L Sbjct: 90 LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL 149 Query: 397 VGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGI 453 N + K+ DFG A+ +Y D+WS G+ Sbjct: 150 YTSKRPNAILKLTDFGFAKETTGEKYDK-----------------------SCDMWSLGV 186 Query: 454 LLTEL--------TTKGRVPYPGMVNREVLDQVERGYRMPCP--PECPESLHDLMCQCWR 503 ++ L + G PGM R + Q Y P P E E + L+ + Sbjct: 187 IMYILLCGYPPFYSNHGLAISPGMKTRIRMGQ----YEFPNPEWSEVSEEVKMLIRNLLK 242 Query: 504 KEPEERPTF 512 EP +R T Sbjct: 243 TEPTQRMTI 251 >1NRV-A nrPDB Length = 105 Score = 43.1 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 25/91 (27%), Positives = 47/91 (51%), Gaps = 9/91 (9%) Query: 147 QAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYK 206 + + W+ G+I+R ES R++ G FL+R+S++ A+ L++ +K+++ Sbjct: 3 RTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQ-----KIKNFQ 57 Query: 207 IRKLDSGGFYITS----RTQFNSLQQLVAYY 233 I + G S T+F+ L QLV +Y Sbjct: 58 ILPCEDDGQTFFSLDDGNTKFSDLIQLVDFY 88 >6CKI-A nrPDB Length = 316 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 41/156 (26%), Positives = 67/156 (42%), Gaps = 34/156 (21%) Query: 338 YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILV 397 Y+V E M GS+L + ++ + + +AS + ++ HRDL+ NIL Sbjct: 87 YLVFEKMRGGSILSHIHKR--RHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILC 144 Query: 398 GE-NLV--CKVADFGLARLIEDN------------------EYTARQGAKFPIKWTAPEA 436 N V K+ DFGL I+ N EY A + ++ + EA Sbjct: 145 EHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPE----VVEAFSEEA 200 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR 472 ++Y + + D+WS G++L L + YP V R Sbjct: 201 SIYDK---RCDLWSLGVILYILLSG----YPPFVGR 229 >2C47-A nrPDB Length = 313 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 63/276 (22%), Positives = 118/276 (42%), Gaps = 25/276 (9%) Query: 269 SLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRH-EKLV 326 + R+ K+G G FGE+ +G T VAIK + +P+ L E + K+L E + Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHL-EYRFYKQLSATEGVP 63 Query: 327 QLYAV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 Q+Y + +V E + G L+ L + L ++ +A Q+ + M YV + Sbjct: 64 QVYYFGPCGKYNAMVLELL--GPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSL 121 Query: 386 VHRDLRAANILVG-----ENLVCKVADFGLARLIEDNE------YTARQGAKFPIKWTAP 434 ++RD++ N LVG + DFGLA+ D E Y + ++ + Sbjct: 122 IYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSI 181 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER--GYRMPCPPEC-- 490 L + + D+ + G + +G +P+ G+ + ++ ++ + P E Sbjct: 182 NTHLGKEQSRRDDLEALGHMFMYF-LRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLC 240 Query: 491 ---PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 PE + + R + E+P ++YL+ D F Sbjct: 241 ENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLF 276 >5M6U-B nrPDB Length = 724 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 35/101 (34%), Positives = 56/101 (55%), Gaps = 11/101 (10%) Query: 135 IPSNYVAPSDSIQAEEWYFGKITRRE-SERLLLNAENPRGTFLVRESET-TKGAYCLSVS 192 + +N + + S+Q EWY+G I+R E +E+L A+ GTFLVR++ T G Y L++ Sbjct: 317 VANNGMNNNMSLQDAEWYWGDISREEVNEKLRDTAD---GTFLVRDASTKMHGDYTLTLR 373 Query: 193 DFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYY 233 KG N K KI D G + + F+S+ +L+ +Y Sbjct: 374 -----KGGNNKLIKIFHRD-GKYGFSDPLTFSSVVELINHY 408 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 41/140 (29%), Positives = 62/140 (44%), Gaps = 20/140 (14%) Query: 106 KKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLL 165 +KG R + +N WL + + Q + + P + W G R ++E LL Sbjct: 586 QKGVRQKKLNE-----WLGNENTEDQYSLVEDDEDLPHHD--EKTWNVGSSNRNKAENLL 638 Query: 166 LNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNS 225 + GTFLVRES + +G Y SV G VKH I K +G + ++S Sbjct: 639 RGKRD--GTFLVRES-SKQGCYACSVV----VDG-EVKHCVINKTATGYGFAEPYNLYSS 690 Query: 226 LQQLVAYYS-----KHADGL 240 L++LV +Y +H D L Sbjct: 691 LKELVLHYQHTSLVQHNDSL 710 >4MD7-E nrPDB Length = 391 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 26/112 (23%), Positives = 53/112 (47%), Gaps = 6/112 (5%) Query: 372 QIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLIE-DNEYTARQGAKFPI 429 +I + Y M +HRD++ N+++ E+ ++ D+GLA EY R +++ Sbjct: 139 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY-- 196 Query: 430 KWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480 + PE + Y + D+WS G +L + + + G N + L ++ + Sbjct: 197 -FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 247 >1UEC-A nrPDB Length = 193 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 18/66 (27%), Positives = 38/66 (57%), Gaps = 4/66 (6%) Query: 80 GPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNY 139 GP+ + T+ A+ DYE + ++++ G+ +++V +E WW + G+IP+++ Sbjct: 7 GPII--LQTYRAIADYEKTSGSEMALSTGDVVEVVEKSESGWWFCQ--MKAKRGWIPASF 62 Query: 140 VAPSDS 145 + P DS Sbjct: 63 LEPLDS 68 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 15/55 (27%), Positives = 28/55 (50%), Gaps = 2/55 (3%) Query: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPS 143 +VA+ Y + ++S +GE +++++ WW+ TGY PS Y+ S Sbjct: 84 YVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDV--TGYFPSMYLQKS 136 >2KK6-A nrPDB Length = 116 Score = 42.4 bits (98), Expect = 6e-04, Method: Composition-based stats. Identities = 29/85 (34%), Positives = 46/85 (54%), Gaps = 11/85 (12%) Query: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR 208 ++WY G I R E++ LL +G FLVRES G Y LSV D + +H+ I+ Sbjct: 17 QDWYHGAIPRIEAQELL----KKQGDFLVRESHGKPGEYVLSVYS-DGQR----RHFIIQ 67 Query: 209 KLDSGGFYITSRTQFNSLQQLVAYY 233 +D+ Y T F+++ QL+ ++ Sbjct: 68 YVDN--MYRFEGTGFSNIPQLIDHH 90 >6EII-A nrPDB Length = 352 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 26/112 (23%), Positives = 53/112 (47%), Gaps = 6/112 (5%) Query: 372 QIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLIE-DNEYTARQGAKFPI 429 +I + Y M +HRD++ N+++ E+ ++ D+GLA EY R +++ Sbjct: 162 EILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY-- 219 Query: 430 KWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480 + PE + Y + D+WS G +L + + + G N + L ++ + Sbjct: 220 -FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAK 270 >4F9B-A nrPDB Length = 361 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 37/156 (23%), Positives = 64/156 (41%), Gaps = 13/156 (8%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTT----RVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKL 325 ++E K+G+G F V++ T ++A+K L P T P E Q + + Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIP-TSHPIRIAAELQCLTVAGGQDN 81 Query: 326 VQ--LYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 V Y + + I Y+ S LD L L ++ + + + + + Sbjct: 82 VMGVKYCFRKNDHVVIAMPYLEHESFLDILNS-----LSFQEVREYMLNLFKALKRIHQF 136 Query: 384 NYVHRDLRAANILVGENL-VCKVADFGLARLIEDNE 418 VHRD++ +N L L + DFGLA+ D + Sbjct: 137 GIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTK 172 >2B3O-A nrPDB Length = 532 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 31/92 (33%), Positives = 46/92 (50%), Gaps = 6/92 (6%) Query: 148 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKG----LNVK 203 +E WY G ++ ++E LL A+ TFLVRES + G + LSV G L V Sbjct: 107 SERWYHGHMSGGQAE-TLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVT 165 Query: 204 HYKIRKLDSGGFYITSRTQFNSLQQLVAYYSK 235 H K+ + G + + F+SL LV ++ K Sbjct: 166 HIKV-MCEGGRYTVGGLETFDSLTDLVEHFKK 196 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 31/104 (29%), Positives = 49/104 (47%), Gaps = 9/104 (8%) Query: 151 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 210 W+ ++ ++E LL G+FL R S +G + LSV G V H +I+ Sbjct: 4 WFHRDLSGLDAE-TLLKGRGVHGSFLARPSRKNQGDFSLSVR-----VGDQVTHIRIQ-- 55 Query: 211 DSGGFY-ITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKP 253 +SG FY + +F +L +LV YY++ L R T+ P Sbjct: 56 NSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 99 >5UUU-A nrPDB Length = 547 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 30/98 (30%), Positives = 50/98 (51%), Gaps = 5/98 (5%) Query: 370 AAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 429 AA+I G+ ++ V+RDL+ ANIL+ E+ +++D GLA + A G Sbjct: 307 AAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH--- 363 Query: 430 KWTAPEAALYG-RFTIKSDVWSFGILLTELTTKGRVPY 466 + APE G + +D +S G +L +L +G P+ Sbjct: 364 GYMAPEVLQKGVAYDSSADWFSLGCMLFKL-LRGHSPF 400 >1GBQ-A nrPDB Length = 74 Score = 42.0 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 19/56 (33%), Positives = 34/56 (60%), Gaps = 1/56 (1%) Query: 85 GVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 G +A YD+++ + +LSFK+G+ L+++N W L+ G+ G+IP NY+ Sbjct: 8 GSMEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELN-GKDGFIPKNYI 62 >3EB0-A nrPDB Length = 383 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 53/229 (23%), Positives = 89/229 (38%), Gaps = 52/229 (22%) Query: 276 LGQGCFGEVW-MGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL----YA 330 LG G FG V + R A+K + P +E +MK L H +++L Y Sbjct: 15 LGTGSFGIVCEVFDIESGKRFALKKV---LQDPRYKNRELDIMKVLDHVNIIKLVDYFYT 71 Query: 331 VVSEEP-----------------------------------IYIVTEYMSKGSLLDFLKG 355 EEP + ++ EY+ +L LK Sbjct: 72 TGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPD-TLHKVLKS 130 Query: 356 --ETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLA- 411 +G+ + + + Q+ + ++ + HRD++ N+LV ++ K+ DFG A Sbjct: 131 FIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLCDFGSAK 190 Query: 412 RLIEDNEYTARQGAKFPIKWTAPEAALYG-RFTIKSDVWSFGILLTELT 459 +LI A ++F + APE L +T D+WS G + EL Sbjct: 191 KLIPSEPSVAYICSRF---YRAPELMLGATEYTPSIDLWSIGCVFGELI 236 >2YUP-A nrPDB Length = 90 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 18/54 (33%), Positives = 30/54 (55%) Query: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPS 143 VA Y ++ E +LSF+KGE + ++ +W+ TG+ G P++YV S Sbjct: 21 VAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTGRQGIFPASYVQVS 74 >3PS5-A nrPDB Length = 595 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 31/92 (33%), Positives = 46/92 (50%), Gaps = 6/92 (6%) Query: 148 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKG----LNVK 203 +E WY G ++ ++E LL A+ TFLVRES + G + LSV G L V Sbjct: 107 SERWYHGHMSGGQAE-TLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVT 165 Query: 204 HYKIRKLDSGGFYITSRTQFNSLQQLVAYYSK 235 H K+ + G + + F+SL LV ++ K Sbjct: 166 HIKVM-CEGGRYTVGGLETFDSLTDLVEHFKK 196 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 31/104 (29%), Positives = 49/104 (47%), Gaps = 9/104 (8%) Query: 151 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 210 W+ ++ ++E LL G+FL R S +G + LSV G V H +I+ Sbjct: 4 WFHRDLSGLDAE-TLLKGRGVHGSFLARPSRKNQGDFSLSVR-----VGDQVTHIRIQ-- 55 Query: 211 DSGGFY-ITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKP 253 +SG FY + +F +L +LV YY++ L R T+ P Sbjct: 56 NSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYP 99 >3PVW-A nrPDB Length = 695 Score = 41.6 bits (96), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 30/98 (30%), Positives = 50/98 (51%), Gaps = 5/98 (5%) Query: 370 AAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 429 AA+I G+ ++ V+RDL+ ANIL+ E+ +++D GLA + A G Sbjct: 298 AAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTH--- 354 Query: 430 KWTAPEAALYG-RFTIKSDVWSFGILLTELTTKGRVPY 466 + APE G + +D +S G +L +L +G P+ Sbjct: 355 GYMAPEVLQKGVAYDSSADWFSLGCMLFKL-LRGHSPF 391 >1KA6-A nrPDB Length = 128 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 21/46 (45%), Positives = 29/46 (63%), Gaps = 1/46 (2%) Query: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSV 191 + A Y GKI+R E+LLL A G++L+R+SE+ G YCL V Sbjct: 1 MDAVAVYHGKISRETGEKLLL-ATGLDGSYLLRDSESVPGVYCLCV 45 >4G3E-A nrPDB Length = 352 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 51/196 (26%), Positives = 85/196 (43%), Gaps = 23/196 (11%) Query: 275 KLGQGCFGEVW-MGTWNGTTRVAIKTLKPGTMSPEAF-LQEAQVMKKLRHEKLVQLYAVV 332 ++G+G FGEV M + A+K ++ E F ++E L ++V LY V Sbjct: 81 RVGRGSFGEVHRMKDKQTGFQCAVKKVRL-----EVFRVEELVACAGLSSPRIVPLYGAV 135 Query: 333 SEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMA----AQIASGMAYVERMNYVH 387 E P + I E + GSL +K + LP+ D A Q G+ Y+ +H Sbjct: 136 REGPWVNIFMELLEGGSLGQLIK----QMGCLPE--DRALYYLGQALEGLEYLHTRRILH 189 Query: 388 RDLRAANILV-GENLVCKVADFGLARLIEDNEY--TARQGAKFPIKWT--APEAALYGRF 442 D++A N+L+ + + DFG A ++ + + G P T APE + Sbjct: 190 GDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPC 249 Query: 443 TIKSDVWSFGILLTEL 458 K D+WS ++ + Sbjct: 250 DAKVDIWSSCCMMLHM 265 >1M27-A nrPDB Length = 104 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 21/46 (45%), Positives = 29/46 (63%), Gaps = 1/46 (2%) Query: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSV 191 + A Y GKI+R E+LLL A G++L+R+SE+ G YCL V Sbjct: 1 MDAVAVYHGKISRETGEKLLL-ATGLDGSYLLRDSESVPGVYCLCV 45 >1OV3-A nrPDB Length = 138 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 16/60 (26%), Positives = 35/60 (58%), Gaps = 2/60 (3%) Query: 86 VTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDS 145 + T+ A+ DYE + ++++ G+ +++V +E WW + G+IP++++ P DS Sbjct: 11 LQTYRAIADYEKTSGSEMALSTGDVVEVVEKSESGWWFCQ--MKAKRGWIPASFLEPLDS 68 Score = 30.4 bits (67), Expect = 2.1, Method: Compositional matrix adjust. Identities = 15/55 (27%), Positives = 28/55 (50%), Gaps = 2/55 (3%) Query: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPS 143 +VA+ Y + ++S +GE +++++ WW+ TGY PS Y+ S Sbjct: 84 YVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDV--TGYFPSMYLQKS 136 >4LQP-A nrPDB Length = 508 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 35/147 (23%), Positives = 67/147 (45%), Gaps = 18/147 (12%) Query: 276 LGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEAFLQ----EAQVMKKLRHEKLVQLYA 330 +G+G FGEV + T ++ A+KTL M + L E V+ +V LY Sbjct: 110 IGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSDSPWVVSLYY 169 Query: 331 VVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD-----MAAQIASGMAYVERMN 384 + + +Y++ E++ G L+ L +R + A+ + + ++ Sbjct: 170 SFQDAQYLYLIMEFLPGGDLMTML-------IRWQLFTEDVTRFYMAECILAIETIHKLG 222 Query: 385 YVHRDLRAANILVGENLVCKVADFGLA 411 ++HR ++ NIL+ K++DFGL+ Sbjct: 223 FIHRAIKPDNILIDIRGHIKLSDFGLS 249 >4JGH-A nrPDB Length = 173 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 26/84 (30%), Positives = 43/84 (51%), Gaps = 3/84 (3%) Query: 151 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR-K 209 WY+G +T E++ L E P GTFL+R+S + +SV L +++ + + Sbjct: 23 WYWGSMTVNEAKEKL--KEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFR 80 Query: 210 LDSGGFYITSRTQFNSLQQLVAYY 233 LDS + QF+S+ L+ YY Sbjct: 81 LDSIICVKSKLKQFDSVVHLIDYY 104 >4N78-F nrPDB Length = 514 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 18/52 (34%), Positives = 28/52 (53%), Gaps = 2/52 (3%) Query: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 VA+YDY E +LSF++G + ++ + W+ + G TG P NYV Sbjct: 457 VVAIYDYTKDKEDELSFQEGAIIYVIKKNDDGWY--EGVMNGVTGLFPGNYV 506 >2CT4-A nrPDB Length = 70 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 17/51 (33%), Positives = 29/51 (56%) Query: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 VA+Y +E +E +S +GE L ++ +GD W G GY+P++Y+ Sbjct: 11 VAIYHFEGSSEGTISMAEGEDLSLMEEDKGDGWTRVRRKEGGEGYVPTSYL 61 >2CHL-A nrPDB Length = 351 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 63/276 (22%), Positives = 118/276 (42%), Gaps = 26/276 (9%) Query: 269 SLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKL-RHEKLV 326 + R+ K+G G FGE+ +G T VAIK + +P+ L E + K+L + + Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHL-EYRFYKQLGSGDGIP 89 Query: 327 QLYAV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 Q+Y + +V E + G L+ L + L ++ +A Q+ S M YV N Sbjct: 90 QVYYFGPCGKYNAMVLELL--GPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNL 147 Query: 386 VHRDLRAANILVGE-----NLVCKVADFGLARLIEDNE------YTARQGAKFPIKWTAP 434 ++RD++ N L+G V + DF LA+ D E Y + ++ + Sbjct: 148 IYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLTGTARYMSI 207 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER--GYRMPCPPEC-- 490 L + + D+ + G + +G +P+ G+ + ++ ++ + P E Sbjct: 208 NTHLGKEQSRRDDLEALGHMFMYF-LRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLC 266 Query: 491 ---PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 PE + + R + E+P ++YL+ D F Sbjct: 267 ENFPE-MATYLRYVRRLDFFEKPDYDYLRKLFTDLF 301 >5TE0-A nrPDB Length = 347 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 60/286 (20%), Positives = 116/286 (40%), Gaps = 32/286 (11%) Query: 257 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ---- 312 G + I R+ + ++ L +G F V++ + + A+K + ++ E LQ Sbjct: 8 GYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRM---FVNNEHDLQVCKR 64 Query: 313 EAQVMKKLRHEKLVQLYAVVSEE--------PIYIVTEYMSKGSLLDFLKGETGKYLRLP 364 E Q+M+ L K + Y S + I+ ++ G +++ + Sbjct: 65 EIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTEN 124 Query: 365 QLVDMAAQIASGMAYVERMN--YVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTAR 422 +++ + +A + + +HRDL+ NIL+ + + DFG A N T Sbjct: 125 EVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEG 184 Query: 423 QGA------KF-PIKWTAPEAA-LYG--RFTIKSDVWSFGILLTELTTKGRVPYPGMVNR 472 A K+ + + APE LY T K+D+W+ G LL +L +P+ G Sbjct: 185 VNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCY-FTLPF-GESQV 242 Query: 473 EVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAF 518 + D + +P + +H L+ +P++RP + F Sbjct: 243 AICDG---NFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYF 285 >3LLT-A nrPDB Length = 360 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 48/221 (21%), Positives = 88/221 (39%), Gaps = 43/221 (19%) Query: 275 KLGQGCFGEVWMGT-WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAV-- 331 K+G G FG V + + A+K ++ + EA ++KK++++ + V Sbjct: 42 KMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQNDDINNNNIVKY 101 Query: 332 ----VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 + + + ++ E + SL + + + + +I + Y+ +M+ H Sbjct: 102 HGKFMYYDHMCLIFEPLGP-SLYEIITRNNYNGFHIEDIKLYCIEILKALNYLRKMSLTH 160 Query: 388 RDLRAANILVGE-----NLV--------------------CKVADFGLARLIEDNE---Y 419 DL+ NIL+ + +L+ K+ DFG A D Sbjct: 161 TDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKSDYHGSII 220 Query: 420 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTT 460 RQ + APE L + + SD+WSFG +L EL T Sbjct: 221 NTRQ-------YRAPEVILNLGWDVSSDMWSFGCVLAELYT 254 >5XVU-A nrPDB Length = 332 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 27/112 (24%), Positives = 50/112 (44%), Gaps = 6/112 (5%) Query: 372 QIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLIE-DNEYTARQGAKFPI 429 QI + Y +HRD++ NI++ EN ++ +GLA EY R +++ Sbjct: 133 QILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRVASRY-- 190 Query: 430 KWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480 + PE + + D+WS G +L + K + G N + L ++ + Sbjct: 191 -YKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAK 241 >2VKN-A nrPDB Length = 70 Score = 39.7 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 20/39 (51%), Positives = 28/39 (71%), Gaps = 2/39 (5%) Query: 102 DLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 ++SF++ E LQ V++ EG WW A + G+TG IPSNYV Sbjct: 23 EISFEQNEILQ-VSDIEGRWWKARR-ANGETGIIPSNYV 59 >2HSP-A nrPDB Length = 71 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 20/50 (40%), Positives = 28/50 (56%), Gaps = 1/50 (2%) Query: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 AL+DY+++ E +L+F K +Q V EG WW Q + PSNYV Sbjct: 11 ALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQL-WFPSNYV 59 >5VEI-A nrPDB Length = 110 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 17/50 (34%), Positives = 31/50 (62%), Gaps = 2/50 (4%) Query: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 A+YD++++T +LSFKKG+ + I+ + +W+ G+ G P +YV Sbjct: 39 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE--HHGRVGIFPISYV 86 >2ED0-A nrPDB Length = 78 Score = 38.5 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 18/51 (35%), Positives = 28/51 (54%), Gaps = 2/51 (3%) Query: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 VA+YDY E +LSF++G + ++ + W+ + G TG P NYV Sbjct: 21 VAIYDYTKDKEDELSFQEGAIIYVIKKNDDGWY--EGVMNGVTGLFPGNYV 69 >2EQI-A nrPDB Length = 69 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 20/53 (37%), Positives = 29/53 (54%), Gaps = 1/53 (1%) Query: 88 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 T ALYDY+++ +L+F +G + V+ G WW + Q Y PSNYV Sbjct: 9 TVKALYDYKAKRSDELTFCRGALIHNVSKEPGGWWKGDYGTRIQQ-YFPSNYV 60 >1YWO-A nrPDB Length = 64 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 19/50 (38%), Positives = 28/50 (56%), Gaps = 1/50 (2%) Query: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 AL+DY+++ E +L+F K +Q V +G WW Q + PSNYV Sbjct: 11 ALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQL-WFPSNYV 59 >3ULR-B nrPDB Length = 65 Score = 38.1 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 20/64 (31%), Positives = 34/64 (53%), Gaps = 6/64 (9%) Query: 80 GPLAG---GVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIP 136 GPL G+T +ALYDY++ + ++SF + + + + WW + G+ G P Sbjct: 1 GPLGSSDLGITA-IALYDYQAAGDDEISFDPDDIITNIEMIDDGWW--RGVCKGRYGLFP 57 Query: 137 SNYV 140 +NYV Sbjct: 58 ANYV 61 >2VIF-A nrPDB Length = 141 Score = 38.1 bits (87), Expect = 0.010, Method: Compositional matrix adjust. Identities = 23/53 (43%), Positives = 32/53 (60%), Gaps = 4/53 (7%) Query: 151 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVK 203 WY+G ITR E+E L N P G+FLVR+S + Y LS+S + K L+ + Sbjct: 26 WYWGPITRWEAEGKLANV--PDGSFLVRDSSDDR--YLLSLSFRSHGKTLHTR 74 >4JRN-A nrPDB Length = 372 Score = 37.7 bits (86), Expect = 0.013, Method: Compositional matrix adjust. Identities = 41/160 (25%), Positives = 67/160 (41%), Gaps = 22/160 (13%) Query: 354 KGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARL 413 K E G +R+ +++Q +A V+ VH D++ AN L+ ++ + DFG R+ Sbjct: 196 KSEFGLVVRM----YLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRI 251 Query: 414 IEDNEYTARQ----GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM 469 N R G + P + P A +T +D W GI L + K R P P Sbjct: 252 ---NNSVGRAIGTPGYEPPER---PFQATGITYTFPTDAWQLGITLYCIWCKER-PTPA- 303 Query: 470 VNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEER 509 D + P PE + DL+ ++P++R Sbjct: 304 ------DGIWDYLHFADCPSTPELVQDLIRSLLNRDPQKR 337 >5M07-A nrPDB Length = 276 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 31/147 (21%), Positives = 67/147 (45%), Gaps = 12/147 (8%) Query: 276 LGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQ----EAQVMKKLRHEKLVQLYA 330 LG GEV++ G A+K L P + + F + E +V +L H +++++ Sbjct: 38 LGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAARLFHPHILEVHD 97 Query: 331 VVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 + ++I +Y+ + L + +++ + +A + Y + +HRD Sbjct: 98 RGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGALDYAHQRGLLHRD 157 Query: 390 LRAANILV-----GENLVCKVADFGLA 411 + AN+++ G+ + +ADFG+A Sbjct: 158 VNPANVVLTSQSAGDQRIL-LADFGIA 183 >5NXJ-A nrPDB Length = 60 Score = 37.4 bits (85), Expect = 0.016, Method: Composition-based stats. Identities = 16/53 (30%), Positives = 29/53 (54%), Gaps = 2/53 (3%) Query: 88 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 T +ALYDY++ + ++SF + + + + WW + G+ G P+NYV Sbjct: 6 TAIALYDYQAAGDDEISFDPDDIITNIEMIDDGWW--RGVCKGRYGLFPANYV 56 >2KBT-A nrPDB Length = 142 Score = 37.0 bits (84), Expect = 0.020, Method: Compositional matrix adjust. Identities = 21/58 (36%), Positives = 33/58 (56%), Gaps = 3/58 (5%) Query: 84 GGVTTFVALYDYESRTETDLSFKKGERLQIVNNT-EGDWWLAHSLSTGQTGYIPSNYV 140 G T A YD+ +R ++LS K+G+ ++I+N + WW G+ G+ PSNYV Sbjct: 3 GTFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIY--GRIGWFPSNYV 58 >1CSN-A nrPDB Length = 298 Score = 37.0 bits (84), Expect = 0.021, Method: Compositional matrix adjust. Identities = 52/265 (19%), Positives = 105/265 (39%), Gaps = 23/265 (8%) Query: 275 KLGQGCFGEVWMGT-WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS 333 ++G+G FG ++ GT +VAIK +P E + K L + Sbjct: 17 RIGEGSFGVIFEGTNLLNNQQVAIK-FEPRRSDAPQLRDEYRTYKLLAGCTGIPNVYYFG 75 Query: 334 EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAA 393 +E ++ V G L+ L G+ + + A Q+ + + + + V+RD++ Sbjct: 76 QEGLHNVLVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKSLVYRDIKPD 135 Query: 394 NILVGE------NLVCKVADFGLARLIED------NEYTARQGAKFPIKWTAPEAALYGR 441 N L+G N++ V DFG+ + D Y ++ ++ + L Sbjct: 136 NFLIGRPNSKNANMIY-VVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYMSINTHLGRE 194 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGM---VNREVLDQV-ERGYRMPCPPEC---PESL 494 + + D+ + G + +G +P+ G+ N++ +++ E+ P C PE Sbjct: 195 QSRRDDLEALGHVFMYF-LRGSLPWQGLKAATNKQKYERIGEKKQSTPLRELCAGFPEEF 253 Query: 495 HDLMCQCWRKEPEERPTFEYLQAFL 519 + M + P ++YLQ Sbjct: 254 YKYMHYARNLAFDATPDYDYLQGLF 278 >1NM7-A nrPDB Length = 69 Score = 36.6 bits (83), Expect = 0.025, Method: Composition-based stats. Identities = 19/56 (33%), Positives = 30/56 (53%), Gaps = 7/56 (12%) Query: 91 ALYDY-ESRTETDLSFKKGERLQIVNNTE-----GDWWLAHSLSTGQTGYIPSNYV 140 ALYD+ E +++ KKG+ + I++ + DWW + G GYIP NY+ Sbjct: 12 ALYDFVPENPEMEVALKKGDLMAILSKKDPLGRDSDWWKVRT-KNGNIGYIPYNYI 66 >1X69-A nrPDB Length = 79 Score = 36.6 bits (83), Expect = 0.026, Method: Composition-based stats. Identities = 17/53 (32%), Positives = 29/53 (54%), Gaps = 2/53 (3%) Query: 88 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 T VALYDY++ + ++SF + + + + WW + G+ G P+NYV Sbjct: 19 TAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWW--RGVCKGRYGLFPANYV 69 >2HW6-A nrPDB Length = 307 Score = 36.2 bits (82), Expect = 0.034, Method: Compositional matrix adjust. Identities = 48/217 (22%), Positives = 91/217 (41%), Gaps = 33/217 (15%) Query: 276 LGQGCFGEVW--MGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK-LVQLYAVV 332 LG+G + +V + NG K S +E + + + + K +++L Sbjct: 21 LGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFF 80 Query: 333 SEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLR 391 ++ Y+V E + GS+L ++ + K+ + + +A+ + ++ HRDL+ Sbjct: 81 EDDTRFYLVFEKLQGGSILAHIQKQ--KHFNEREASRVVRDVAAALDFLHTKGIAHRDLK 138 Query: 392 AANILVG--ENLV-CKVADFGLARLIEDN---------EYTARQGAKFPIKWTAPE---- 435 NIL E + K+ DF L ++ N E T G+ ++ APE Sbjct: 139 PENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSA---EYMAPEVVEV 195 Query: 436 ----AALYGRFTIKSDVWSFGILLTELTTKGRVPYPG 468 A Y + + D+WS G++L + G P+ G Sbjct: 196 FTDQATFYDK---RCDLWSLGVVLY-IMLSGYPPFVG 228 >1N5Z-A nrPDB Length = 92 Score = 36.2 bits (82), Expect = 0.034, Method: Composition-based stats. Identities = 19/56 (33%), Positives = 30/56 (53%), Gaps = 7/56 (12%) Query: 91 ALYDY-ESRTETDLSFKKGERLQIVNNTE-----GDWWLAHSLSTGQTGYIPSNYV 140 ALYD+ E +++ KKG+ + I++ + DWW + G GYIP NY+ Sbjct: 19 ALYDFVPENPEMEVALKKGDLMAILSKKDPLGRDSDWWKVRT-KNGNIGYIPYNYI 73 >2PZ1-A nrPDB Length = 466 Score = 36.2 bits (82), Expect = 0.035, Method: Compositional matrix adjust. Identities = 16/57 (28%), Positives = 35/57 (61%), Gaps = 2/57 (3%) Query: 84 GGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 G V AL+D+ + + +L FK G+ +++++ T +WW ++ G+ G+ P+++V Sbjct: 28 GSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGR-VADGE-GWFPASFV 82 >4NT4-A nrPDB Length = 312 Score = 36.2 bits (82), Expect = 0.036, Method: Compositional matrix adjust. Identities = 56/288 (19%), Positives = 115/288 (39%), Gaps = 43/288 (14%) Query: 269 SLRLEVKLGQGCFGEVWMG-TWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQ 327 + R+ K+G G FGE+ +G VAIK + +P+ L+ R KL+ Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHLE-------YRFYKLLG 65 Query: 328 LYAVVSEEPI--------------YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373 +A + + I +V E + G L+ L + L ++ +A Q+ Sbjct: 66 SHADNAPDGIPRIYHLGTCGGRYNAMVLELL--GLSLEDLFNICARKFSLKTVLMIAKQL 123 Query: 374 ASGMAYVERMNYVHRDLRAANILVGEN-----LVCKVADFGLARLIEDNE------YTAR 422 + YV + ++RD++ N L+G + + DFGLA+ D + Y Sbjct: 124 LHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREH 183 Query: 423 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER-- 480 + ++ + + + + D+ + G + +G +P+ G+ + ++ ++ Sbjct: 184 KSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYF-LRGSLPWQGLKADTLKERYQKIG 242 Query: 481 GYRMPCPPEC-----PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 + P E PE + R + E P +++L+ +D F Sbjct: 243 DTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLF 290 >2V1R-A nrPDB Length = 80 Score = 35.8 bits (81), Expect = 0.042, Method: Composition-based stats. Identities = 19/56 (33%), Positives = 30/56 (53%), Gaps = 7/56 (12%) Query: 91 ALYDY-ESRTETDLSFKKGERLQIVNNTE-----GDWWLAHSLSTGQTGYIPSNYV 140 ALYD+ E +++ KKG+ + I++ + DWW + G GYIP NY+ Sbjct: 19 ALYDFVPENPEMEVALKKGDLMAILSKKDPLGRDSDWWKVRT-KNGNIGYIPYNYI 73 >5UU1-A nrPDB Length = 324 Score = 35.8 bits (81), Expect = 0.042, Method: Compositional matrix adjust. Identities = 44/201 (21%), Positives = 86/201 (42%), Gaps = 24/201 (11%) Query: 338 YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILV 397 ++V E + G L + G+ G + + ++ + ++ + Y+ YVH D++AAN+L+ Sbjct: 107 FMVMERL--GIDLQKISGQNGTFKK-STVLQLGIRMLDVLEYIHENEYVHGDIKAANLLL 163 Query: 398 GENLVCKV--ADFGLARLIEDN------EYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 449 G +V AD+GL+ N + R+G I++T+ +A + +SDV Sbjct: 164 GYKNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVE 223 Query: 450 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM-----------PCPPECPESLHDLM 498 G + G++P+ + V Q + + P C E L+ Sbjct: 224 ILGYCMLRWLC-GKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLV 282 Query: 499 CQCWRKEPEERPTFEYLQAFL 519 C +E+P ++ L+ L Sbjct: 283 C-AHSLAYDEKPNYQALKKIL 302 >2BBU-A nrPDB Length = 164 Score = 35.8 bits (81), Expect = 0.048, Method: Compositional matrix adjust. Identities = 30/95 (31%), Positives = 48/95 (50%), Gaps = 15/95 (15%) Query: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205 +Q +Y+ +T E+ LLL+AE P GTFL+R+S + + LSV K L + Sbjct: 20 LQESGFYWSAVTGGEAN-LLLSAE-PAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRI--- 74 Query: 206 KIRKLDSGGFYITS---RTQ----FNSLQQLVAYY 233 + + G F + S TQ F+ + +LV +Y Sbjct: 75 ---QCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 106 >6EAS-A nrPDB Length = 308 Score = 35.8 bits (81), Expect = 0.051, Method: Compositional matrix adjust. Identities = 48/228 (21%), Positives = 98/228 (42%), Gaps = 43/228 (18%) Query: 317 MKKLRHEKLVQLYAVVSEEPIY---IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQ- 372 + K+ H+ + L EE + +V EY G+L + L ++R + +D A+ Sbjct: 95 LSKVSHKNFMNLLGYCEEEHPFTRVMVFEYAPNGTLFEHL------HVREAEKLDWMARL 148 Query: 373 -IASGMAY-VERMNYVH-----RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGA 425 I+ G+AY +E M+ + R+ + + + ++ KV+D + + T Sbjct: 149 RISMGIAYCLEHMHQLQTPAALRNFDSTTVYLTDDFAAKVSDLEFWNDAKGHNSTTNNEL 208 Query: 426 KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYP---GMVNREVLDQVERGY 482 F +P+ ++ V +G++L E+ T GRVP G + V E G Sbjct: 209 AF-----SPD--------MEDIVRKYGMVLLEILT-GRVPSSEDDGPLENWVSRYFEGGM 254 Query: 483 RMP---------CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLED 521 R+ P + +L +++ C ++P++RP + + A + + Sbjct: 255 RLEELIDPSIGFFPEDTARALCEVVRSCIDRDPKKRPQMKEVAARMRE 302 >2HDV-A nrPDB Length = 111 Score = 35.8 bits (81), Expect = 0.053, Method: Composition-based stats. Identities = 24/87 (27%), Positives = 44/87 (50%), Gaps = 7/87 (8%) Query: 151 WYFGKITRRESERLLLNA-ENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209 W+ G ++R ++ +L+L G FLVR+SET +G L+ N +G KH ++ Sbjct: 11 WFHGMLSRLKAAQLVLEGGTGSHGVFLVRQSETRRGECVLTF----NFQG-KAKHLRL-S 64 Query: 210 LDSGGFYITSRTQFNSLQQLVAYYSKH 236 L++ G F S+ ++ ++ H Sbjct: 65 LNAAGQCRVQHLHFQSIFDMLEHFRVH 91 >5X18-A nrPDB Length = 295 Score = 35.0 bits (79), Expect = 0.078, Method: Compositional matrix adjust. Identities = 36/149 (24%), Positives = 67/149 (44%), Gaps = 9/149 (6%) Query: 275 KLGQGCFGEVWMGT--WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVV 332 K+G+G FG ++ GT NG VAIK T +P+ E + K L + Sbjct: 14 KIGEGSFGVLFEGTNMINGVP-VAIKFEPRKTEAPQ-LRDEYKTYKILNGTPNIPYAYYF 71 Query: 333 SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRA 392 +E ++ + G L+ L G+ + +V +A Q+ + + + + ++RD++ Sbjct: 72 GQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHAHDLIYRDIKP 131 Query: 393 ANILVG-----ENLVCKVADFGLARLIED 416 N L+G + + DFG+A+ D Sbjct: 132 DNFLIGRPGQPDANNIHLIDFGMAKQYRD 160 >2HMH-A nrPDB Length = 152 Score = 35.0 bits (79), Expect = 0.081, Method: Compositional matrix adjust. Identities = 30/95 (31%), Positives = 48/95 (50%), Gaps = 15/95 (15%) Query: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205 +Q +Y+ +T E+ LLL+AE P GTFL+R+S + + LSV K L + Sbjct: 31 LQESGFYWSAVTGGEAN-LLLSAE-PAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRI--- 85 Query: 206 KIRKLDSGGFYITS---RTQ----FNSLQQLVAYY 233 + + G F + S TQ F+ + +LV +Y Sbjct: 86 ---QCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 117 >1UGV-A nrPDB Length = 72 Score = 35.0 bits (79), Expect = 0.087, Method: Compositional matrix adjust. Identities = 19/50 (38%), Positives = 30/50 (60%), Gaps = 1/50 (2%) Query: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 ALY ++ +++LSF G V+ ++ WL +L+ G+TG IP NYV Sbjct: 15 ALYACKAEHDSELSFTAGTVFDNVHPSQEPGWLEGTLN-GKTGLIPENYV 63 >4GL9-E nrPDB Length = 143 Score = 34.7 bits (78), Expect = 0.10, Method: Compositional matrix adjust. Identities = 35/117 (29%), Positives = 54/117 (46%), Gaps = 15/117 (12%) Query: 124 AHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETT 183 AH L T + V +Q +Y+ +T E+ LLL+AE P GTFL+R+S Sbjct: 3 AHDLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEAN-LLLSAE-PAGTFLIRDSSDQ 60 Query: 184 KGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITS---RTQ----FNSLQQLVAYY 233 + + LSV K L + + + G F + S TQ F+ + +LV +Y Sbjct: 61 RHFFTLSVKTQSGTKNLRI------QCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 111 >5LJ3-H nrPDB Length = 591 Score = 34.7 bits (78), Expect = 0.11, Method: Compositional matrix adjust. Identities = 14/27 (51%), Positives = 19/27 (70%), Gaps = 1/27 (3%) Query: 387 HRDLRAANILVGENLVCK-VADFGLAR 412 HRDL NIL+G +++CK V DF L + Sbjct: 41 HRDLFQVNILIGRDIICKNVVDFTLNK 67 >4O1O-A nrPDB Length = 717 Score = 34.3 bits (77), Expect = 0.13, Method: Compositional matrix adjust. Identities = 44/207 (21%), Positives = 83/207 (40%), Gaps = 37/207 (17%) Query: 273 EVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR-HEKLVQLYAV 331 E K+ G +++G + VA+K G+ + QE ++ R ++ +V Y Sbjct: 351 EYKIADTAEGGIYLGLYE-DQEVAVKRFSEGSTRGQ---QEVSCLQSSRANDNVVTFYGS 406 Query: 332 VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQ-----IASGMAYVERMNYV 386 S+ V + + +L + L G + P D +A+ + + + R Y Sbjct: 407 ESDGSCLHVCLALCEYTLQEHLANHRGDAV--PNEEDESARNILSSLFKAIGELHRSGYS 464 Query: 387 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA-PEAALYGRFTIK 445 H+DL+ NIL+ +ADF + IKW P+ IK Sbjct: 465 HQDLQPQNILIDSKNGTFLADFDKS-----------------IKWAEDPQ-------KIK 500 Query: 446 SDVWSFGILLTELTTKGRVPYPGMVNR 472 D+ + G+L+ + KG + + + N+ Sbjct: 501 RDLEALGLLVLYVVKKGDISFETLKNQ 527 >4MT6-A nrPDB Length = 456 Score = 34.3 bits (77), Expect = 0.16, Method: Compositional matrix adjust. Identities = 15/64 (23%), Positives = 36/64 (56%), Gaps = 4/64 (6%) Query: 79 AGPLAGG--VTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIP 136 +G L G + + A++D+ + +L+FK G+ +++++ + DWW + G+ P Sbjct: 8 SGMLITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQ--IDDEEGWFP 65 Query: 137 SNYV 140 +++V Sbjct: 66 ASFV 69 >2RSV-A nrPDB Length = 403 Score = 33.9 bits (76), Expect = 0.18, Method: Compositional matrix adjust. Identities = 39/179 (21%), Positives = 74/179 (41%), Gaps = 34/179 (18%) Query: 258 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVA-----IKTLKPGTMSPE---- 308 +AK W++ + +GQG FG +++ N + V + ++P P Sbjct: 39 MAKKEWKVG-------LPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTEL 91 Query: 309 AFLQEA----QVMKKLRHEKL----------VQLYAVVSEEPIYIVTEYMSKGSLLDFLK 354 F Q A Q+ K +R KL L+ + +++ + GS L + Sbjct: 92 KFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIY 149 Query: 355 GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKV--ADFGLA 411 K ++ ++ +I + Y+ YVH D++A+N+L+ +V D+GLA Sbjct: 150 EANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 208 >2PVN-A nrPDB Length = 352 Score = 33.9 bits (76), Expect = 0.19, Method: Compositional matrix adjust. Identities = 22/112 (19%), Positives = 49/112 (43%), Gaps = 6/112 (5%) Query: 372 QIASGMAYVERMNYVHRDLRAANILVGENL-VCKVADFGLARLIE-DNEYTARQGAKFPI 429 ++ + Y +HRD++ N+++ L ++ D+GLA EY R +++ Sbjct: 154 ELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRY-- 211 Query: 430 KWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480 + PE + + D+WS G + + + + G N + L ++ + Sbjct: 212 -FKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAK 262 >2XKX-A nrPDB Length = 721 Score = 33.9 bits (76), Expect = 0.20, Method: Compositional matrix adjust. Identities = 20/56 (35%), Positives = 31/56 (55%), Gaps = 9/56 (16%) Query: 91 ALYDYESRTETD-----LSFKKGERLQIVNNTEGDWWLA---HSLS-TGQTGYIPS 137 AL+DY+ + LSF+ G+ L +++ + +WW A HS S T G+IPS Sbjct: 432 ALFDYDKTKDCGFLSQALSFRFGDVLHVIDAGDEEWWQARRVHSDSETDDIGFIPS 487 >5CEK-A nrPDB Length = 263 Score = 33.1 bits (74), Expect = 0.31, Method: Compositional matrix adjust. Identities = 38/159 (23%), Positives = 66/159 (41%), Gaps = 11/159 (6%) Query: 359 KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG--ENLVCKVADFGLARLI-- 414 K LR + + QI S +A+ + V DL+ + E ++ ++ Sbjct: 95 KRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKG 154 Query: 415 EDNEYTARQGAKFPIKWTAPEAA-LYGRFTIKS-DVWSFGILLTELTTKGRVPYPGMVNR 472 ED+ + + G + +PE G ++ K+ DVWS G++L L GR P+ Sbjct: 155 EDDALSDKHGCP---AYVSPEILNTTGTYSGKAADVWSLGVMLYTLLV-GRYPFHDSDPS 210 Query: 473 EVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPT 511 + ++ RG + P L+ R+EP ER T Sbjct: 211 ALFSKIRRG-QFCIPEHISPKARCLIRSLLRREPSERLT 248 >2LAV-A nrPDB Length = 361 Score = 33.1 bits (74), Expect = 0.31, Method: Compositional matrix adjust. Identities = 36/173 (20%), Positives = 74/173 (42%), Gaps = 27/173 (15%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVA-----IKTLKPGTMSPE----AFLQEA 314 ++ ++ ++ + +GQG FG +++ N + V + ++P P F Q A Sbjct: 31 DMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 Query: 315 ----QVMKKLRHEKLVQL----------YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY 360 Q+ K +R KL L + + +++ + GS L + K Sbjct: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRF--GSDLQKIYEANAKR 148 Query: 361 LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKV--ADFGLA 411 ++ ++ +I + Y+ YVH D++A+N+L+ +V D+GLA Sbjct: 149 FSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 >5CLR-A nrPDB Length = 451 Score = 33.1 bits (74), Expect = 0.34, Method: Compositional matrix adjust. Identities = 27/116 (23%), Positives = 52/116 (44%), Gaps = 6/116 (5%) Query: 297 IKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGE 356 +K++K S F E + KL +LV + + YI+T ++ KG L K Sbjct: 109 LKSVKIDAESLTEFTNEKDTLSKLG--RLVGTFFNEQTQVHYILTTFI-KGIDLSRYKNA 165 Query: 357 TGKYLRLP---QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFG 409 + L +++ + + + + +HRDL+ NI++ ++ C + DFG Sbjct: 166 LPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNIMLDADMQCHLVDFG 221 >1WXU-A nrPDB Length = 93 Score = 32.7 bits (73), Expect = 0.36, Method: Compositional matrix adjust. Identities = 18/53 (33%), Positives = 29/53 (54%), Gaps = 3/53 (5%) Query: 91 ALYDYESRTETDLSFKKGERLQIV---NNTEGDWWLAHSLSTGQTGYIPSNYV 140 A YD+ + ++ ++SF+ G+ L + + WL SL TG IP+NYV Sbjct: 22 AEYDFVAVSDEEISFRAGDMLNLALKEQQPKVRGWLLASLDGQTTGLIPANYV 74 >5O2P-A nrPDB Length = 100 Score = 32.7 bits (73), Expect = 0.37, Method: Compositional matrix adjust. Identities = 20/51 (39%), Positives = 32/51 (62%), Gaps = 5/51 (9%) Query: 91 ALYDYESRTETDLSFKKGERLQIV-NNTEG--DWWLAHSLSTGQTGYIPSN 138 ALYD + + +LSF+KG+ + ++ +T+G WWL SL G+ G +P N Sbjct: 12 ALYDNVAESPDELSFRKGDIMTVLERDTQGLDGWWLC-SLH-GRQGIVPGN 60 >5O2Q-A nrPDB Length = 99 Score = 32.7 bits (73), Expect = 0.37, Method: Compositional matrix adjust. Identities = 20/51 (39%), Positives = 32/51 (62%), Gaps = 5/51 (9%) Query: 91 ALYDYESRTETDLSFKKGERLQIVN-NTEG--DWWLAHSLSTGQTGYIPSN 138 ALYD + + +LSF+KG+ + ++ +T+G WWL SL G+ G +P N Sbjct: 12 ALYDNVAESPDELSFRKGDIMTVLERDTQGLDGWWLC-SLH-GRQGIVPGN 60 >2MIO-A nrPDB Length = 70 Score = 32.7 bits (73), Expect = 0.37, Method: Compositional matrix adjust. Identities = 18/50 (36%), Positives = 28/50 (56%), Gaps = 1/50 (2%) Query: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 A+Y E+ ++LSF+ G + V + WL +L+ G+ G IP NYV Sbjct: 19 AVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLN-GKRGLIPQNYV 67 >2KYM-A nrPDB Length = 120 Score = 32.7 bits (73), Expect = 0.41, Method: Compositional matrix adjust. Identities = 16/56 (28%), Positives = 31/56 (55%), Gaps = 1/56 (1%) Query: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLS-TGQTGYIPSNYVAPSD 144 V LY++++ + +L GE L I + + +W++A ++ G G +P +YV D Sbjct: 7 VTLYEFKAERDDELDVSPGENLSICAHYDYEWFIAKPINRLGGPGLVPVSYVRIID 62 >6DC0-A nrPDB Length = 292 Score = 32.7 bits (73), Expect = 0.43, Method: Compositional matrix adjust. Identities = 38/159 (23%), Positives = 66/159 (41%), Gaps = 11/159 (6%) Query: 359 KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG--ENLVCKVADFGLARLI-- 414 K LR + + QI S +A+ + V DL+ + E ++ ++ Sbjct: 92 KRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKG 151 Query: 415 EDNEYTARQGAKFPIKWTAPEAA-LYGRFTIKS-DVWSFGILLTELTTKGRVPYPGMVNR 472 ED+ + + G + +PE G ++ K+ DVWS G++L L GR P+ Sbjct: 152 EDDALSDKHGCP---AYVSPEILNTTGTYSGKAADVWSLGVMLYTLLV-GRYPFHDSDPS 207 Query: 473 EVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPT 511 + ++ RG + P L+ R+EP ER T Sbjct: 208 ALFSKIRRG-QFCIPEHISPKARCLIRSLLRREPSERLT 245 >2ENM-A nrPDB Length = 77 Score = 32.3 bits (72), Expect = 0.48, Method: Compositional matrix adjust. Identities = 16/59 (27%), Positives = 30/59 (50%), Gaps = 1/59 (1%) Query: 83 AGGVTTFVALYDYESR-TETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 +G T +YD+ + +L+ +GE + + N G WL + G+ G +P++YV Sbjct: 6 SGMATKARVMYDFAAEPGNNELTVTEGEIITVTNPNVGGGWLEGKNNKGEQGLVPTDYV 64 >3CXL-A nrPDB Length = 463 Score = 32.3 bits (72), Expect = 0.50, Method: Compositional matrix adjust. Identities = 21/79 (26%), Positives = 38/79 (48%), Gaps = 11/79 (13%) Query: 152 YFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLD 211 + G I+R +++LL+ AE G++L+RES+ G Y L++ + +L Sbjct: 54 FHGMISREAADQLLIVAE---GSYLIRESQRQPGTYTLALRFGSQTRNF--------RLY 102 Query: 212 SGGFYITSRTQFNSLQQLV 230 G + +F S+ LV Sbjct: 103 YDGKHFVGEKRFESIHDLV 121 >5OAT-A nrPDB Length = 411 Score = 32.3 bits (72), Expect = 0.50, Method: Compositional matrix adjust. Identities = 35/151 (23%), Positives = 64/151 (42%), Gaps = 21/151 (13%) Query: 376 GMAYVERMNYVHRDLRAANILVG----ENLVCKVADFGLARLIEDN-------EYTARQG 424 G+A++ HRDL++ N+L+ E+ + ++DFG + N Y +G Sbjct: 165 GVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKG 224 Query: 425 AKFPIKWTAPEAALY--GRFTI----KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 + APE G F++ K+D+W+ G + E+ P+ G + + Sbjct: 225 GNTAL--MAPEIICQKPGTFSVLNYSKADLWAVGAIAYEIFNCHN-PFYGPSRLKNFNYK 281 Query: 479 ERGYRMPCPPECPESLHDLMCQCWRKEPEER 509 E G P E P + L+ ++ P +R Sbjct: 282 E-GDLPKLPDEVPTVIQALVANLLKRNPNKR 311 >5O2M-A nrPDB Length = 81 Score = 32.3 bits (72), Expect = 0.58, Method: Compositional matrix adjust. Identities = 20/51 (39%), Positives = 32/51 (62%), Gaps = 5/51 (9%) Query: 91 ALYDYESRTETDLSFKKGERLQIVN-NTEG--DWWLAHSLSTGQTGYIPSN 138 ALYD + + +LSF+KG+ + ++ +T+G WWL SL G+ G +P N Sbjct: 12 ALYDNVAESPDELSFRKGDIMTVLERDTQGLDGWWLC-SLH-GRQGIVPGN 60 >6M7Z-A nrPDB Length = 319 Score = 32.0 bits (71), Expect = 0.71, Method: Compositional matrix adjust. Identities = 48/184 (26%), Positives = 76/184 (41%), Gaps = 37/184 (20%) Query: 344 MSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR--DLRAANILVGENL 401 +SKG + D L ETG+ P + +AA + + + + + +HR +L + ++L + Sbjct: 128 LSKGLVGDML--ETGR--SHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDGTV 183 Query: 402 VCKVADFGLARLIEDNEYTARQGAKFPIKWTAPE---------AALYGRFTIKSDVWSFG 452 V D E + G + TAPE A GR T+KSDV+S G Sbjct: 184 VLGGLDTAAPIGTETRLWVGFFGQE-----TAPEIDRNFLADLALTQGRHTVKSDVYSLG 238 Query: 453 IL---LTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEER 509 + L +L G + G +R + Q + E L L + +EP R Sbjct: 239 VAFRNLVQLLGNGNL---GPEDRGAVRQ-----------DHLELLDKLSQKMIEEEPGNR 284 Query: 510 PTFE 513 PT E Sbjct: 285 PTIE 288 >3ENH-A nrPDB Length = 540 Score = 32.0 bits (71), Expect = 0.78, Method: Compositional matrix adjust. Identities = 19/103 (18%), Positives = 55/103 (53%), Gaps = 5/103 (4%) Query: 311 LQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMA 370 +++++ ++ R+ LV+ + + + P + +K ++ ++ G+ K + + +D+A Sbjct: 381 IRKSRTAREARYLALVKDFGIPA--PYIFDVDLDNKRIMMSYINGKLAKDV-IEDNLDIA 437 Query: 371 AQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARL 413 +I + + + + +H DL +N + ++L + DFGL ++ Sbjct: 438 YKIGEIVGKLHKNDVIHNDLTTSNFIFDKDLY--IIDFGLGKI 478 >1RPY-A nrPDB Length = 114 Score = 31.6 bits (70), Expect = 0.82, Method: Composition-based stats. Identities = 25/88 (28%), Positives = 45/88 (51%), Gaps = 9/88 (10%) Query: 151 WYFGKITRRESERLLLNAENPR--GTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR 208 W+ G ++R ++ +L+L A PR G F++R+SET G L+ N +G KH ++ Sbjct: 13 WFHGTLSRVKAAQLVL-AGGPRSHGLFVIRQSETRPGECVLTF----NFQG-KAKHLRL- 65 Query: 209 KLDSGGFYITSRTQFNSLQQLVAYYSKH 236 L+ G F S+ ++ ++ H Sbjct: 66 SLNGHGQCHVQHLWFQSVFDMLRHFHTH 93 >2RQT-A nrPDB Length = 61 Score = 31.2 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 9/34 (26%), Positives = 21/34 (61%) Query: 92 LYDYESRTETDLSFKKGERLQIVNNTEGDWWLAH 125 +YD ++ + +L+F +GE + + + +WW+ H Sbjct: 7 IYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGH 40 >4IX6-A nrPDB Length = 350 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 16/47 (34%), Positives = 23/47 (48%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ 312 P++ L LG G FG V+ G + G V +K K M+ E L+ Sbjct: 18 PKDIRVLPGPLGSGNFGTVFRGVFKGDQDVVLKNAKADVMAAEELLE 64 >2DYB-A nrPDB Length = 341 Score = 31.2 bits (69), Expect = 1.3, Method: Compositional matrix adjust. Identities = 14/50 (28%), Positives = 27/50 (54%), Gaps = 2/50 (4%) Query: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 AL+D+ ++ +L+FK G+ + +++ DW G TG P ++V Sbjct: 179 ALFDFTGNSKLELNFKAGDVIFLLSRINKDWL--EGTVRGATGIFPLSFV 226 >1Z9Q-A nrPDB Length = 79 Score = 30.4 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 14/50 (28%), Positives = 27/50 (54%), Gaps = 2/50 (4%) Query: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 AL+D+ ++ +L+FK G+ + +++ DW G TG P ++V Sbjct: 23 ALFDFTGNSKLELNFKAGDVIFLLSRINKDW--LEGTVRGATGIFPLSFV 70 >1W6X-A nrPDB Length = 60 Score = 30.4 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 14/50 (28%), Positives = 27/50 (54%), Gaps = 2/50 (4%) Query: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 AL+D+ ++ +L+FK G+ + +++ DW G TG P ++V Sbjct: 9 ALFDFTGNSKLELNFKAGDVIFLLSRINKDW--LEGTVRGATGIFPLSFV 56 >4DEX-A nrPDB Length = 339 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 19/68 (27%), Positives = 31/68 (45%), Gaps = 11/68 (16%) Query: 78 RAGPLAGGVTTFVALYDYESRTETD-------LSFKKGERLQIVNNTEGDWWLAHSLSTG 130 + P+A V T V+ Y + E D +SF+ + L + DWW+ + G Sbjct: 35 KTKPVAFAVRTNVS---YSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEG 91 Query: 131 -QTGYIPS 137 + G+IPS Sbjct: 92 CEIGFIPS 99 >2ED1-A nrPDB Length = 76 Score = 30.4 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 9/34 (26%), Positives = 21/34 (61%) Query: 92 LYDYESRTETDLSFKKGERLQIVNNTEGDWWLAH 125 +YD ++ + +L+F +GE + + + +WW+ H Sbjct: 16 IYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGH 49 >1XA6-A nrPDB Length = 466 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 28/114 (24%), Positives = 49/114 (42%), Gaps = 15/114 (13%) Query: 122 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWY----FGKITRRESERLLLNAENPRGTFLV 177 W ++ Q P + P + ++Y G I+R +++ LL E G +++ Sbjct: 24 WKSYLYQLQQEAPRPKRIICPREVENRPKYYGREFHGIISREQADELLGGVE---GAYIL 80 Query: 178 RESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVA 231 RES+ G Y L++ F N + LN +L G + +F S+ LV Sbjct: 81 RESQRQPGCYTLALR-FGN-QTLNY------RLFHDGKHFVGEKRFESIHDLVT 126 >2YDL-A nrPDB Length = 69 Score = 30.0 bits (66), Expect = 2.6, Method: Composition-based stats. Identities = 14/51 (27%), Positives = 28/51 (54%), Gaps = 4/51 (7%) Query: 92 LYDYESRTETDLSFKKGERLQIVNNTEGD--WWLAHSLSTGQTGYIPSNYV 140 ++ YE++ + +L+ K+G+ + ++N D WW G+ G P N+V Sbjct: 8 IFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGE--LNGRRGVFPDNFV 56 >2GTJ-A nrPDB Length = 96 Score = 30.0 bits (66), Expect = 2.6, Method: Composition-based stats. Identities = 17/44 (38%), Positives = 28/44 (63%), Gaps = 5/44 (11%) Query: 100 ETDLSFKKGERLQIV---NNTEGDWWLAHSLSTGQTGYIPSNYV 140 + +LSFK+GE+++I+ +N EG WL + + G GYI + V Sbjct: 41 KNELSFKQGEQIEIIRITDNPEGK-WLGRT-ARGSYGYIKTTAV 82 >2K6D-A nrPDB Length = 62 Score = 30.0 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 14/51 (27%), Positives = 28/51 (54%), Gaps = 4/51 (7%) Query: 92 LYDYESRTETDLSFKKGERLQIVNNTEGD--WWLAHSLSTGQTGYIPSNYV 140 ++ YE++ + +L+ K+G+ + ++N D WW G+ G P N+V Sbjct: 9 IFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGE--LNGRRGVFPDNFV 57 >1VYV-A nrPDB Length = 359 Score = 30.0 bits (66), Expect = 2.7, Method: Compositional matrix adjust. Identities = 22/78 (28%), Positives = 35/78 (44%), Gaps = 5/78 (6%) Query: 78 RAGPLAGGVTTFV----ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTG-QT 132 ++ P+A V T V AL + + +SF + L I DWW+ + G + Sbjct: 40 KSKPVAFAVKTNVSYCGALDEDVPVPSSAVSFDAKDFLHIKEKYNNDWWIGRLVKEGCEI 99 Query: 133 GYIPSNYVAPSDSIQAEE 150 G+IPS + IQ E+ Sbjct: 100 GFIPSPLRLENIRIQQEQ 117 >1K4U-S nrPDB Length = 62 Score = 30.0 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 15/53 (28%), Positives = 27/53 (50%), Gaps = 2/53 (3%) Query: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPS 143 AL+ YE+ DL F++G+ + +++ +W S G+ G P +V S Sbjct: 10 ALFSYEATQPEDLEFQEGDIILVLSKVNEEWLEGE--SKGKVGIFPKVFVEDS 60 >2K9G-A nrPDB Length = 73 Score = 29.6 bits (65), Expect = 3.2, Method: Composition-based stats. Identities = 14/51 (27%), Positives = 28/51 (54%), Gaps = 4/51 (7%) Query: 92 LYDYESRTETDLSFKKGERLQIVNNTEGD--WWLAHSLSTGQTGYIPSNYV 140 ++ YE++ + +L+ K+G+ + ++N D WW G+ G P N+V Sbjct: 15 IFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGE--LNGRRGVFPDNFV 63 >2DA9-A nrPDB Length = 70 Score = 29.6 bits (65), Expect = 3.2, Method: Composition-based stats. Identities = 14/51 (27%), Positives = 28/51 (54%), Gaps = 4/51 (7%) Query: 92 LYDYESRTETDLSFKKGERLQIVNNTEGD--WWLAHSLSTGQTGYIPSNYV 140 ++ YE++ + +L+ K+G+ + ++N D WW G+ G P N+V Sbjct: 13 IFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGE--LNGRRGVFPDNFV 61 >6EWX-A nrPDB Length = 484 Score = 29.6 bits (65), Expect = 3.2, Method: Compositional matrix adjust. Identities = 12/69 (17%), Positives = 35/69 (50%), Gaps = 5/69 (7%) Query: 334 EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD-----MAAQIASGMAYVERMNYVHR 388 ++ + ++T + + DF++ + P++ + + Q+ +G+ +++ +HR Sbjct: 175 QDCVVVITREVPHQTASDFVRDSVASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHR 234 Query: 389 DLRAANILV 397 DL N+L+ Sbjct: 235 DLCLENLLL 243 >1WWR-A nrPDB Length = 171 Score = 29.6 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 16/48 (33%), Positives = 24/48 (50%), Gaps = 1/48 (2%) Query: 140 VAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAY 187 + P S +E YF K+ RE++R E P G +V+E E A+ Sbjct: 14 LVPRGSHMGKE-YFLKVALREAKRAFEKGEVPVGAIIVKEGEIISKAH 60 >2RQW-A nrPDB Length = 105 Score = 29.6 bits (65), Expect = 3.7, Method: Composition-based stats. Identities = 15/56 (26%), Positives = 29/56 (51%), Gaps = 1/56 (1%) Query: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLST-GQTGYIPSNYVAPSD 144 + LYD+++ +L+ GE L I + +W++A + G G +P +V+ D Sbjct: 6 IVLYDFKAEKADELTTYVGENLFICAHHNCEWFIAKPIGRLGGPGLVPVGFVSIID 61 >4WSI-A nrPDB Length = 394 Score = 29.3 bits (64), Expect = 4.8, Method: Compositional matrix adjust. Identities = 15/52 (28%), Positives = 25/52 (48%), Gaps = 7/52 (13%) Query: 81 PLAGGVTTFVALYDYESRT-------ETDLSFKKGERLQIVNNTEGDWWLAH 125 P V A +DY+ E LSF+KG+ L +++ + +WW A+ Sbjct: 111 PAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAY 162 >4DIO-A nrPDB Length = 405 Score = 28.9 bits (63), Expect = 5.2, Method: Compositional matrix adjust. Identities = 22/73 (30%), Positives = 35/73 (47%), Gaps = 11/73 (15%) Query: 414 IEDNEYTARQGA-----KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPG 468 +ED E+ A + A + ++ +AAL K D I++T GR P P Sbjct: 239 VEDEEFKAAETAGGYAKEMSGEYQVKQAALVAEHIAKQD-----IVITTALIPGR-PAPR 292 Query: 469 MVNREVLDQVERG 481 +V RE+LD ++ G Sbjct: 293 LVTREMLDSMKPG 305 >1JE3-A nrPDB Length = 97 Score = 28.9 bits (63), Expect = 5.2, Method: Composition-based stats. Identities = 9/33 (27%), Positives = 21/33 (63%) Query: 465 PYPGMVNREVLDQVERGYRMPCPPECPESLHDL 497 PYP + E + Q+++G + +CP+S++++ Sbjct: 38 PYPAVATLEAMPQLKKGEILEVVSDCPQSINNI 70 >1T0J-A nrPDB Length = 132 Score = 28.9 bits (63), Expect = 5.4, Method: Compositional matrix adjust. Identities = 19/68 (27%), Positives = 30/68 (44%), Gaps = 11/68 (16%) Query: 78 RAGPLAGGVTTFVALYDYESRTETD-------LSFKKGERLQIVNNTEGDWWLAHSLSTG 130 + P+A V T V Y + E D +SF+ + L + DWW+ + G Sbjct: 43 KTKPVAFAVRTNVR---YSAAQEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEG 99 Query: 131 -QTGYIPS 137 + G+IPS Sbjct: 100 CEIGFIPS 107 >6C5X-D nrPDB Length = 164 Score = 28.9 bits (63), Expect = 5.5, Method: Composition-based stats. Identities = 19/64 (29%), Positives = 32/64 (50%), Gaps = 7/64 (10%) Query: 171 PRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYIT-SRTQFNSLQQL 229 P GTFL+R+S+ + +SV + +K + +G F + S+ F+ L QL Sbjct: 50 PIGTFLIRDSKQKNCFFAISVKTARETVSIRIKFH------AGKFSLDGSKELFSCLFQL 103 Query: 230 VAYY 233 V +Y Sbjct: 104 VEHY 107 >4G1U-C nrPDB Length = 266 Score = 28.9 bits (63), Expect = 6.2, Method: Compositional matrix adjust. Identities = 21/74 (28%), Positives = 33/74 (44%), Gaps = 11/74 (14%) Query: 450 SFGILLTELTTKGRVPYPGMVNREVLDQV----------ERGYRMPCPPECPE-SLHDLM 498 +F ++E+ GR PY G +R+ L QV +R YR+ E L ++ Sbjct: 97 AFPFSVSEVIQMGRAPYGGSQDRQALQQVMAQTDCLALAQRDYRVLSGGEQQRVQLARVL 156 Query: 499 CQCWRKEPEERPTF 512 Q W+ +P R F Sbjct: 157 AQLWQPQPTPRWLF 170 >2NWM-A nrPDB Length = 65 Score = 28.5 bits (62), Expect = 6.9, Method: Composition-based stats. Identities = 12/48 (25%), Positives = 27/48 (56%), Gaps = 2/48 (4%) Query: 93 YDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV 140 +D+++++ +L+ +KG+ + I + +W G+ G P+NYV Sbjct: 8 FDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGE--HHGRLGIFPANYV 53 >5UP2-B nrPDB Length = 831 Score = 28.5 bits (62), Expect = 8.1, Method: Compositional matrix adjust. Identities = 17/60 (28%), Positives = 29/60 (48%), Gaps = 2/60 (3%) Query: 95 YESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFG 154 Y S+ E F++ L ++ G W+ SL TG T IP + + S+ ++W +G Sbjct: 222 YCSKDEATYIFEEARSLGLMG--YGFVWIVPSLVTGNTDIIPYEFPSGLVSVSYDDWDYG 279 >4OAU-C nrPDB Length = 699 Score = 28.5 bits (62), Expect = 8.1, Method: Compositional matrix adjust. Identities = 42/200 (21%), Positives = 75/200 (37%), Gaps = 32/200 (16%) Query: 275 KLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE 334 K+ G +++G + VA+KT G SP A + + + + LV Y S Sbjct: 350 KIADTSEGGIYLGFYE-KQEVAVKTFCEG--SPRAQREVSCLQSSRENSHLVTFYGSESH 406 Query: 335 EPIYIVTEYMSKGSL---LDFLKGETGKYLRLPQLVDMAAQIASGMAYVE-RMNYVHRDL 390 V + + +L LD +GE + ++ + I + + Y H+DL Sbjct: 407 RGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDL 466 Query: 391 RAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA-PEAALYGRFTIKSDVW 449 + NIL+ +ADF + IKW P+ +K D+ Sbjct: 467 QPQNILIDSKKAAHLADFDKS-----------------IKWAGDPQ-------EVKRDLE 502 Query: 450 SFGILLTELTTKGRVPYPGM 469 G L+ + KG + + + Sbjct: 503 DLGRLVLYVVKKGSISFEDL 522 >1ESM-A nrPDB Length = 316 Score = 28.5 bits (62), Expect = 8.6, Method: Compositional matrix adjust. Identities = 17/88 (19%), Positives = 45/88 (51%), Gaps = 2/88 (2%) Query: 296 AIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKG 355 A++ P T+S + + + + L E++ ++Y +S + ++ + + ++L+ G Sbjct: 22 ALRDSVPMTLSEDEIARLKGINEDLSLEEVAEIYLPLSRLLNFYISSNLRRQAVLEQFLG 81 Query: 356 ETGKYLRLPQLVDMAAQIASGMAYVERM 383 G+ R+P ++ +A +A G + R+ Sbjct: 82 TNGQ--RIPYIISIAGSVAVGKSTTARV 107 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2H8H-A nrPDB 824 0.0 6F3F-A nrPDB 680 0.0 1AD5-A nrPDB 560 e-160 2FO0-A nrPDB 523 e-149 4XI2-A nrPDB 460 e-130 1K9A-A nrPDB 459 e-129 4XEY-B nrPDB 450 e-127 5SYS-A nrPDB 439 e-123 2DQ7-X nrPDB 416 e-117 2PL0-A nrPDB 384 e-107 4CSV-A nrPDB 373 e-104 2OZO-A nrPDB 371 e-103 3A4O-X nrPDB 368 e-102 2HK5-A nrPDB 367 e-102 4E93-A nrPDB 363 e-100 6NPU-A nrPDB 337 9e-93 2XYN-A nrPDB 334 5e-92 5H2U-A nrPDB 322 3e-88 3DKO-A nrPDB 316 2e-86 4EBW-A nrPDB 315 4e-86 2Y6O-A nrPDB 313 8e-86 2R2P-A nrPDB 313 1e-85 1JPA-A nrPDB 313 2e-85 4P5Q-A nrPDB 312 2e-85 4Y93-A nrPDB 311 6e-85 2J0K-A nrPDB 309 2e-84 5MJB-A nrPDB 308 3e-84 6E4F-A nrPDB 308 3e-84 5L6P-A nrPDB 308 5e-84 2VWV-A nrPDB 305 4e-83 3QGY-A nrPDB 304 8e-83 3SXS-A nrPDB 303 1e-82 4H1J-A nrPDB 301 5e-82 1BYG-A nrPDB 301 7e-82 3KUL-B nrPDB 300 8e-82 4PDO-A nrPDB 299 2e-81 4XCU-A nrPDB 298 5e-81 3TT0-A nrPDB 297 8e-81 6GQK-A nrPDB 296 2e-80 3GQL-A nrPDB 295 3e-80 4AT3-A nrPDB 295 4e-80 3V5Q-A nrPDB 294 6e-80 2PSQ-A nrPDB 294 7e-80 5A46-A nrPDB 294 8e-80 4K33-A nrPDB 292 3e-79 2OGV-A nrPDB 290 1e-78 5EG3-A nrPDB 288 4e-78 5U6B-A nrPDB 288 4e-78 4HZS-A nrPDB 288 5e-78 1U54-B nrPDB 288 6e-78 4XLV-A nrPDB 288 6e-78 5AMN-A nrPDB 285 3e-77 3BEA-A nrPDB 285 3e-77 3KRL-A nrPDB 285 4e-77 4R7H-A nrPDB 284 5e-77 1U59-A nrPDB 284 7e-77 5KMM-A nrPDB 284 7e-77 3ZBF-A nrPDB 283 1e-76 3G0E-A nrPDB 283 1e-76 6BSD-A nrPDB 280 1e-75 5FM2-A nrPDB 280 1e-75 3I81-A nrPDB 280 1e-75 5X02-A nrPDB 279 1e-75 3BBT-B nrPDB 279 1e-75 1FVR-A nrPDB 279 2e-75 5HLW-A nrPDB 279 2e-75 4XUF-A nrPDB 279 2e-75 5GRN-A nrPDB 279 3e-75 3CJF-A nrPDB 279 3e-75 1LUF-A nrPDB 278 4e-75 3QUP-A nrPDB 278 5e-75 6FEX-A nrPDB 278 6e-75 3PPZ-A nrPDB 278 6e-75 3C1X-A nrPDB 275 3e-74 5U6C-A nrPDB 271 4e-73 6FER-A nrPDB 271 6e-73 4GS6-A nrPDB 270 8e-73 4FL3-A nrPDB 270 1e-72 3PP0-A nrPDB 270 1e-72 3PLS-A nrPDB 269 2e-72 5GNK-A nrPDB 266 2e-71 3LZB-A nrPDB 266 2e-71 5X5O-A nrPDB 264 6e-71 6DBN-A nrPDB 263 1e-70 3ZZW-A nrPDB 263 1e-70 3AOX-A nrPDB 263 1e-70 5C26-A nrPDB 263 2e-70 6DBM-A nrPDB 263 2e-70 4OLI-A nrPDB 262 3e-70 3COM-A nrPDB 261 6e-70 5VO2-A nrPDB 261 8e-70 4E20-A nrPDB 260 1e-69 4UY9-A nrPDB 259 2e-69 4MVF-A nrPDB 259 2e-69 4LRM-A nrPDB 259 3e-69 5JN2-A nrPDB 258 3e-69 3DTC-A nrPDB 257 6e-69 4CFF-A nrPDB 257 7e-69 2YZA-A nrPDB 257 8e-69 3MN3-A nrPDB 257 1e-68 5HI2-A nrPDB 257 1e-68 5EZV-A nrPDB 256 1e-68 4LG4-A nrPDB 256 2e-68 4REW-A nrPDB 256 2e-68 4CFH-A nrPDB 256 2e-68 5HIE-A nrPDB 256 2e-68 6AO5-A nrPDB 256 2e-68 4RED-A nrPDB 255 3e-68 4QMW-A nrPDB 255 4e-68 3Q5I-A nrPDB 254 5e-68 3HZT-A nrPDB 254 5e-68 5ES1-A nrPDB 254 6e-68 4UYA-A nrPDB 254 7e-68 2QNJ-A nrPDB 254 7e-68 3DXN-A nrPDB 254 8e-68 3MA6-A nrPDB 254 8e-68 5WNO-A nrPDB 254 1e-67 3IO7-A nrPDB 253 1e-67 2W1I-A nrPDB 253 2e-67 3OMV-A nrPDB 252 2e-67 5KZ7-A nrPDB 252 4e-67 5IG1-A nrPDB 251 6e-67 3LIJ-A nrPDB 251 7e-67 3H4J-B nrPDB 250 1e-66 2WQN-A nrPDB 249 2e-66 4CZT-A nrPDB 249 3e-66 5D9K-A nrPDB 248 4e-66 4CQG-A nrPDB 248 4e-66 2BPM-A nrPDB 248 4e-66 3DFA-A nrPDB 247 6e-66 3NCG-A nrPDB 247 6e-66 2BDW-A nrPDB 247 6e-66 4D2V-A nrPDB 247 7e-66 4D28-A nrPDB 247 8e-66 5YKS-A nrPDB 247 1e-65 3KK8-A nrPDB 247 1e-65 2Z7Q-A nrPDB 246 2e-65 6FDY-U nrPDB 245 3e-65 2V7O-A nrPDB 245 4e-65 4FZF-B nrPDB 245 4e-65 4UZD-A nrPDB 245 4e-65 2XIK-A nrPDB 245 4e-65 2JC6-A nrPDB 244 7e-65 5FG8-A nrPDB 243 1e-64 5KCV-A nrPDB 242 2e-64 4YNZ-A nrPDB 242 2e-64 2JDO-A nrPDB 242 2e-64 5D7A-A nrPDB 242 2e-64 3NIZ-A nrPDB 242 2e-64 4HVI-A nrPDB 242 3e-64 4JXF-A nrPDB 242 3e-64 2VN9-A nrPDB 242 3e-64 4FG9-A nrPDB 242 3e-64 2VZ6-A nrPDB 241 6e-64 2JAM-A nrPDB 241 6e-64 5U6Y-A nrPDB 241 6e-64 3DAK-A nrPDB 239 2e-63 1FOT-A nrPDB 239 2e-63 3D2K-A nrPDB 239 2e-63 2HAK-A nrPDB 239 2e-63 3LMG-A nrPDB 238 5e-63 4APC-A nrPDB 237 7e-63 3MV5-A nrPDB 237 7e-63 6C9D-A nrPDB 237 9e-63 3BHH-A nrPDB 237 9e-63 4I6B-A nrPDB 237 9e-63 4L42-A nrPDB 236 1e-62 6HXF-B nrPDB 236 2e-62 4RLP-A nrPDB 236 2e-62 4RGJ-A nrPDB 236 2e-62 5DBX-A nrPDB 236 2e-62 5HVK-A nrPDB 236 3e-62 2UV2-A nrPDB 236 3e-62 6FD3-A nrPDB 235 3e-62 4B6L-A nrPDB 235 4e-62 4YZB-A nrPDB 234 5e-62 3IS5-A nrPDB 234 6e-62 3SOA-A nrPDB 234 6e-62 4RA4-A nrPDB 234 7e-62 3DB8-A nrPDB 234 7e-62 5EFQ-A nrPDB 234 9e-62 5F9E-A nrPDB 234 9e-62 3F3Z-A nrPDB 233 1e-61 2F57-A nrPDB 233 1e-61 3Q53-A nrPDB 233 1e-61 4J52-A nrPDB 233 1e-61 2OU7-A nrPDB 233 2e-61 6CMJ-A nrPDB 233 2e-61 4KRC-A nrPDB 232 2e-61 4WNO-A nrPDB 232 3e-61 5WAX-A nrPDB 232 4e-61 6GU6-A nrPDB 231 4e-61 3HDN-A nrPDB 231 5e-61 4NIF-A nrPDB 231 7e-61 4YFF-A nrPDB 231 8e-61 4JG6-A nrPDB 231 9e-61 2J90-A nrPDB 230 1e-60 1G3N-A nrPDB 230 1e-60 4NST-A nrPDB 230 2e-60 2W4O-A nrPDB 229 2e-60 3ZUT-A nrPDB 229 2e-60 6QAU-A nrPDB 229 3e-60 4XBR-A nrPDB 228 4e-60 4JDH-A nrPDB 228 4e-60 2Q0N-A nrPDB 228 4e-60 2YAB-A nrPDB 228 4e-60 4FIE-A nrPDB 228 4e-60 3UC3-A nrPDB 228 5e-60 4BBM-A nrPDB 228 5e-60 1V0B-A nrPDB 228 5e-60 3TXO-A nrPDB 228 5e-60 5J5T-A nrPDB 228 6e-60 2XNP-A nrPDB 228 6e-60 5XZW-A nrPDB 227 6e-60 5X3F-B nrPDB 227 7e-60 4WB7-A nrPDB 227 8e-60 5YV8-A nrPDB 227 8e-60 3UDB-A nrPDB 227 8e-60 2A27-A nrPDB 227 1e-59 5N23-A nrPDB 227 1e-59 4TNB-A nrPDB 226 1e-59 4KS7-A nrPDB 226 1e-59 1VZO-A nrPDB 226 1e-59 3HNG-A nrPDB 226 2e-59 1ZWS-A nrPDB 226 2e-59 2YCR-A nrPDB 226 2e-59 4NEU-A nrPDB 226 3e-59 4TPT-A nrPDB 225 3e-59 3TKU-A nrPDB 225 4e-59 6CQF-A nrPDB 224 5e-59 5JZN-A nrPDB 224 6e-59 4B8L-A nrPDB 224 6e-59 1CM8-A nrPDB 224 7e-59 3GUB-A nrPDB 224 7e-59 4AU8-A nrPDB 224 7e-59 4AGU-A nrPDB 224 8e-59 3KN6-A nrPDB 223 1e-58 1U5R-A nrPDB 223 2e-58 2GCD-A nrPDB 222 2e-58 3I6U-A nrPDB 222 3e-58 4AF3-A nrPDB 222 4e-58 4U41-A nrPDB 221 5e-58 4F0G-A nrPDB 221 6e-58 3ORZ-A nrPDB 220 1e-57 3GC9-A nrPDB 219 2e-57 3NYO-A nrPDB 219 2e-57 5FET-A nrPDB 219 2e-57 4PDS-A nrPDB 219 2e-57 6J5U-C nrPDB 219 2e-57 4AW2-A nrPDB 219 2e-57 2X4F-A nrPDB 219 3e-57 6BDL-A nrPDB 219 3e-57 5TOS-A nrPDB 219 3e-57 2I0E-A nrPDB 219 3e-57 5WNL-A nrPDB 219 3e-57 6E9W-A nrPDB 219 3e-57 3PFQ-A nrPDB 219 4e-57 4MYG-A nrPDB 218 5e-57 4BGQ-A nrPDB 218 5e-57 2BRG-A nrPDB 218 6e-57 3OHT-A nrPDB 218 6e-57 5LOH-A nrPDB 217 7e-57 4EWQ-A nrPDB 217 7e-57 4QTB-A nrPDB 217 1e-56 2W96-B nrPDB 217 1e-56 6E2O-A nrPDB 216 2e-56 5NGU-A nrPDB 216 2e-56 5DYK-A nrPDB 216 3e-56 6DTL-A nrPDB 216 3e-56 4EQM-A nrPDB 216 3e-56 1KOB-A nrPDB 216 3e-56 1PHK-A nrPDB 216 3e-56 3ZDU-A nrPDB 215 3e-56 5AWM-A nrPDB 215 4e-56 6ED6-A nrPDB 215 4e-56 5UIU-A nrPDB 214 5e-56 3A8W-A nrPDB 214 6e-56 3HKO-A nrPDB 214 1e-55 2F9G-A nrPDB 214 1e-55 4C0T-A nrPDB 212 4e-55 1UA2-A nrPDB 211 6e-55 2Y7J-A nrPDB 211 6e-55 4FR4-A nrPDB 211 7e-55 5G6V-A nrPDB 211 8e-55 6CTH-A nrPDB 211 8e-55 6CCF-A nrPDB 209 2e-54 4YHJ-A nrPDB 209 2e-54 3FME-A nrPDB 209 3e-54 3UTO-A nrPDB 209 3e-54 6BXI-A nrPDB 208 4e-54 3C51-A nrPDB 208 4e-54 3VN9-A nrPDB 208 4e-54 2Y4I-B nrPDB 208 4e-54 5Z33-A nrPDB 207 7e-54 1KOA-A nrPDB 207 9e-54 4QNY-A nrPDB 207 9e-54 4CRS-A nrPDB 207 9e-54 3MIA-A nrPDB 207 1e-53 2XS0-A nrPDB 207 1e-53 1JNK-A nrPDB 206 2e-53 3ALO-A nrPDB 206 2e-53 3FI2-A nrPDB 206 2e-53 3E7O-A nrPDB 205 3e-53 4AN9-A nrPDB 204 8e-53 5LPV-A nrPDB 204 9e-53 5LPZ-A nrPDB 204 1e-52 3OZ6-A nrPDB 204 1e-52 3LM0-A nrPDB 203 2e-52 4OTD-A nrPDB 203 2e-52 3ORP-A nrPDB 202 2e-52 4PWN-A nrPDB 202 3e-52 2VD5-A nrPDB 202 3e-52 2A1A-B nrPDB 202 3e-52 3GC0-A nrPDB 202 4e-52 2BUJ-A nrPDB 201 5e-52 1NY3-A nrPDB 201 5e-52 3VHK-A nrPDB 201 5e-52 2OZA-A nrPDB 201 6e-52 1ZXE-A nrPDB 201 6e-52 3KA0-A nrPDB 200 9e-52 5Y86-A nrPDB 200 1e-51 3REP-A nrPDB 199 2e-51 3FXW-A nrPDB 199 3e-51 4E7W-A nrPDB 199 4e-51 4ZSG-A nrPDB 198 4e-51 4IC8-A nrPDB 198 4e-51 5O2B-A nrPDB 198 5e-51 3UIU-A nrPDB 198 5e-51 5O2C-A nrPDB 197 8e-51 3PVW-A nrPDB 197 9e-51 4M7I-A nrPDB 197 1e-50 5UUU-A nrPDB 197 1e-50 6AMW-A nrPDB 197 1e-50 5ZTN-A nrPDB 197 1e-50 4O2Z-A nrPDB 197 1e-50 5XD6-A nrPDB 196 2e-50 4BTF-A nrPDB 196 2e-50 2ABL-A nrPDB 195 3e-50 5TQX-A nrPDB 194 7e-50 5B2L-A nrPDB 194 7e-50 2WTK-C nrPDB 194 9e-50 2QKW-B nrPDB 194 1e-49 3UIM-A nrPDB 193 2e-49 5O0Y-A nrPDB 192 2e-49 4Y83-A nrPDB 192 3e-49 3N9X-A nrPDB 191 6e-49 5IKW-A nrPDB 191 6e-49 4M69-B nrPDB 190 8e-49 5AR8-A nrPDB 190 9e-49 5AP3-A nrPDB 190 9e-49 4RT7-A nrPDB 190 1e-48 3RP9-A nrPDB 189 3e-48 5KKR-C nrPDB 189 3e-48 6GVJ-A nrPDB 189 3e-48 1TKI-A nrPDB 189 4e-48 3EQC-A nrPDB 188 4e-48 4X7Q-B nrPDB 188 5e-48 6HV0-A nrPDB 188 6e-48 6FYV-A nrPDB 188 6e-48 5X8I-B nrPDB 187 8e-48 3PG1-A nrPDB 187 8e-48 4PL5-B nrPDB 187 8e-48 3DLS-A nrPDB 187 8e-48 3HAJ-A nrPDB 187 1e-47 4X3F-A nrPDB 187 1e-47 4OW8-A nrPDB 187 2e-47 5AIR-A nrPDB 186 2e-47 6B2Q-A nrPDB 186 2e-47 3HMP-A nrPDB 186 2e-47 4C59-A nrPDB 186 2e-47 3NIE-A nrPDB 186 2e-47 4LQP-A nrPDB 185 4e-47 2I6L-A nrPDB 185 4e-47 3QA8-A nrPDB 185 6e-47 6BFN-A nrPDB 184 6e-47 4KIK-B nrPDB 184 6e-47 3MDY-A nrPDB 184 8e-47 2ZMD-A nrPDB 184 8e-47 4MWI-A nrPDB 184 1e-46 3BGP-A nrPDB 184 1e-46 2RIO-A nrPDB 183 1e-46 5USZ-A nrPDB 183 2e-46 6O6Q-A nrPDB 183 2e-46 5TUR-A nrPDB 182 2e-46 4L00-A nrPDB 182 2e-46 4RC3-A nrPDB 182 3e-46 1S9I-A nrPDB 182 3e-46 3Q4U-A nrPDB 182 5e-46 2WO6-A nrPDB 181 5e-46 6CKI-A nrPDB 181 6e-46 4IDT-A nrPDB 180 2e-45 1PY5-A nrPDB 179 2e-45 4TN6-A nrPDB 179 3e-45 4M66-A nrPDB 179 4e-45 5VD3-A nrPDB 179 4e-45 3E3P-A nrPDB 179 4e-45 5FQD-C nrPDB 177 9e-45 5VC6-A nrPDB 177 1e-44 4M4Z-A nrPDB 176 2e-44 3M42-A nrPDB 175 3e-44 3RAW-A nrPDB 175 3e-44 3MY0-A nrPDB 174 1e-43 5E8V-A nrPDB 173 1e-43 4G3E-A nrPDB 172 2e-43 3SV0-A nrPDB 172 3e-43 4IAN-A nrPDB 172 3e-43 3EB0-A nrPDB 171 5e-43 4JLC-A nrPDB 171 9e-43 2H34-A nrPDB 170 1e-42 3G2F-A nrPDB 169 3e-42 5UNP-A nrPDB 169 3e-42 4EUU-A nrPDB 169 4e-42 4EUT-A nrPDB 169 4e-42 2WTK-B nrPDB 168 6e-42 6NT9-A nrPDB 167 8e-42 6O8B-A nrPDB 167 1e-41 4XHH-A nrPDB 167 2e-41 5C01-A nrPDB 165 3e-41 5VDK-A nrPDB 165 3e-41 4I94-A nrPDB 165 4e-41 3SOC-A nrPDB 165 4e-41 4BTK-A nrPDB 165 5e-41 4NFN-A nrPDB 164 8e-41 4CRL-A nrPDB 164 1e-40 4WOV-A nrPDB 163 2e-40 2QLU-A nrPDB 161 6e-40 5J0A-A nrPDB 160 2e-39 4XHL-A nrPDB 158 4e-39 2CMW-A nrPDB 156 3e-38 1GRI-A nrPDB 153 1e-37 2C47-A nrPDB 153 2e-37 2JD5-A nrPDB 149 2e-36 2PMN-X nrPDB 147 1e-35 4L68-A nrPDB 145 5e-35 3QD2-B nrPDB 144 8e-35 5X1R-A nrPDB 144 9e-35 4MD7-E nrPDB 142 3e-34 4LFI-A nrPDB 141 8e-34 6EII-A nrPDB 140 1e-33 5UV4-A nrPDB 137 2e-32 4F9B-A nrPDB 135 5e-32 3T04-A nrPDB 132 4e-31 4BNE-A nrPDB 126 2e-29 2PZI-A nrPDB 119 4e-27 5GZA-A nrPDB 118 4e-27 4Y12-A nrPDB 118 5e-27 4XZ1-A nrPDB 114 1e-25 1A81-A nrPDB 113 1e-25 2EKX-A nrPDB 105 4e-23 4H1O-A nrPDB 105 6e-23 2AUG-A nrPDB 104 9e-23 5U06-A nrPDB 103 2e-22 2B3O-A nrPDB 101 5e-22 3PS5-A nrPDB 101 9e-22 5JMQ-A nrPDB 100 1e-21 6CMQ-A nrPDB 100 2e-21 1NRV-A nrPDB 98 8e-21 2LQW-A nrPDB 96 4e-20 2CRH-A nrPDB 94 2e-19 5M6U-B nrPDB 87 1e-17 2KK6-A nrPDB 87 2e-17 2EYZ-A nrPDB 83 2e-16 1MIL-A nrPDB 82 5e-16 2PLE-A nrPDB 81 1e-15 2EOB-A nrPDB 80 2e-15 3JV3-A nrPDB 80 3e-15 4JGH-A nrPDB 79 5e-15 3GF9-A nrPDB 77 2e-14 1GCQ-A nrPDB 76 4e-14 Sequences not found previously or not previously below threshold: 3TAC-A nrPDB 215 5e-56 2HW6-A nrPDB 191 5e-49 5TE0-A nrPDB 185 3e-47 3LLT-A nrPDB 155 6e-38 4NT4-A nrPDB 152 4e-37 2CHL-A nrPDB 151 9e-37 2PVN-A nrPDB 147 1e-35 6HMD-A nrPDB 146 2e-35 5X18-A nrPDB 142 3e-34 5XVU-A nrPDB 141 9e-34 1CSN-A nrPDB 141 9e-34 4WUA-A nrPDB 140 2e-33 2X7G-A nrPDB 137 1e-32 6DC0-A nrPDB 127 1e-29 5CEK-A nrPDB 127 2e-29 5M07-A nrPDB 121 9e-28 5L2Q-C nrPDB 120 2e-27 5OAT-A nrPDB 117 1e-26 6EQI-C nrPDB 108 8e-24 6J6I-B nrPDB 106 3e-23 4JRN-A nrPDB 97 3e-20 6EAS-A nrPDB 95 5e-20 5GZ9-A nrPDB 92 5e-19 5CLR-A nrPDB 90 2e-18 2LCT-A nrPDB 87 2e-17 2LAV-A nrPDB 87 2e-17 2RSV-A nrPDB 87 2e-17 4O1O-A nrPDB 87 3e-17 5UU1-A nrPDB 84 1e-16 4IX6-A nrPDB 83 3e-16 5DMZ-A nrPDB 80 3e-15 >2H8H-A nrPDB Length = 535 Score = 824 bits (2129), Expect = 0.0, Method: Composition-based stats. Identities = 535/535 (100%), Positives = 535/535 (100%) Query: 2 GSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEP 61 GSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEP Sbjct: 1 GSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEP 60 Query: 62 KLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 121 KLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW Sbjct: 61 KLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW 120 Query: 122 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 181 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE Sbjct: 121 WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESE 180 Query: 182 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 241 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC Sbjct: 181 TTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLC 240 Query: 242 HRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLK 301 HRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLK Sbjct: 241 HRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLK 300 Query: 302 PGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYL 361 PGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYL Sbjct: 301 PGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYL 360 Query: 362 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA 421 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA Sbjct: 361 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA 420 Query: 422 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG Sbjct: 421 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 480 Query: 482 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL Sbjct: 481 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 535 >6F3F-A nrPDB Length = 455 Score = 680 bits (1756), Expect = 0.0, Method: Composition-based stats. Identities = 449/451 (99%), Positives = 451/451 (100%) Query: 86 VTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDS 145 VTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDS Sbjct: 5 VTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDS 64 Query: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY Sbjct: 65 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 124 Query: 206 KIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEI 265 KIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEI Sbjct: 125 KIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEI 184 Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKL 325 PRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKL Sbjct: 185 PRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKL 244 Query: 326 VQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 VQLYAVVSEEPIYIVTEYM+KGSLLDFLKGETGKYLRLPQLVDM+AQIASGMAYVERMNY Sbjct: 245 VQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNY 304 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK Sbjct: 305 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 364 Query: 446 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKE 505 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKE Sbjct: 365 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKE 424 Query: 506 PEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536 PEERPTFEYLQAFLEDYFTSTEPQYQPGENL Sbjct: 425 PEERPTFEYLQAFLEDYFTSTEPQYQPGENL 455 >1AD5-A nrPDB Length = 438 Score = 560 bits (1443), Expect = e-160, Method: Composition-based stats. Identities = 270/443 (60%), Positives = 347/443 (78%), Gaps = 12/443 (2%) Query: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA 148 VALYDYE+ DLSF+KG+++ ++ + G+WW A SL+T + GYIPSNYVA DS++ Sbjct: 5 VVALYDYEAIHHEDLSFQKGDQMVVLEES-GEWWKARSLATRKEGYIPSNYVARVDSLET 63 Query: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR 208 EEW+F I+R+++ER LL N G+F++R+SETTKG+Y LSV D+D +G VKHYKIR Sbjct: 64 EEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIR 123 Query: 209 KLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRE 268 LD+GGFYI+ R+ F++LQ+LV +Y K DGLC +L+ C +SKPQ + KDAWEIPRE Sbjct: 124 TLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQ-KPWEKDAWEIPRE 182 Query: 269 SLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL 328 SL+LE KLG G FGEVWM T+N T+VA+KT+KPG+MS EAFL EA VMK L+H+KLV+L Sbjct: 183 SLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKL 242 Query: 329 YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 +AVV++EPIYI+TE+M+KGSLLDFLK + G LP+L+D +AQIA GMA++E+ NY+HR Sbjct: 243 HAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHR 302 Query: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 448 DLRAANILV +LVCK+ADFGLAR GAKFPIKWTAPEA +G FTIKSDV Sbjct: 303 DLRAANILVSASLVCKIADFGLAR----------VGAKFPIKWTAPEAINFGSFTIKSDV 352 Query: 449 WSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEE 508 WSFGILL E+ T GR+PYPGM N EV+ +ERGYRMP P CPE L+++M +CW+ PEE Sbjct: 353 WSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEE 412 Query: 509 RPTFEYLQAFLEDYFTSTEPQYQ 531 RPTFEY+Q+ L+D++T+TE QYQ Sbjct: 413 RPTFEYIQSVLDDFYTATESQYQ 435 >2FO0-A nrPDB Length = 495 Score = 523 bits (1347), Expect = e-149, Method: Composition-based stats. Identities = 196/451 (43%), Positives = 283/451 (62%), Gaps = 15/451 (3%) Query: 79 AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVN-NTEGDWWLAHSLSTGQTGYIPS 137 AGP FVALYD+ + + LS KGE+L+++ N G+W A + GQ G++PS Sbjct: 33 AGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT-KNGQ-GWVPS 90 Query: 138 NYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNA 197 NY+ P +S++ WY G ++R +E LL + N G+FLVRESE++ G +S+ Sbjct: 91 NYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR----- 143 Query: 198 KGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQ 256 V HY+I G Y++S ++FN+L +LV ++S ADGL L P +KP Sbjct: 144 YEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVY 203 Query: 257 GLAKD--AWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQE 313 G++ + WE+ R + ++ KLG G +GEV+ G W + VA+KTLK TM E FL+E Sbjct: 204 GVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKE 263 Query: 314 AQVMKKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQ 372 A VMK+++H LVQL V + EP YI+TE+M+ G+LLD+L+ + + L+ MA Q Sbjct: 264 AAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQ 323 Query: 373 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT 432 I+S M Y+E+ N++HR+L A N LVGEN + KVADFGL+RL+ + YTA GAKFPIKWT Sbjct: 324 ISSAMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWT 383 Query: 433 APEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE 492 APE+ Y +F+IKSDVW+FG+LL E+ T G PYPG+ +V + +E+ YRM P CPE Sbjct: 384 APESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPE 443 Query: 493 SLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 +++LM CW+ P +RP+F + E F Sbjct: 444 KVYELMRACWQWNPSDRPSFAEIHQAFETMF 474 >4XI2-A nrPDB Length = 446 Score = 460 bits (1183), Expect = e-130, Method: Composition-based stats. Identities = 166/442 (37%), Positives = 258/442 (58%), Gaps = 10/442 (2%) Query: 86 VTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAP-SD 144 + VALYDY DL +KGE I+ + WW A GQ GYIPSNY+ D Sbjct: 3 LKKVVALYDYMPMNANDLQLRKGEEYFILEESNLPWWRARD-KNGQEGYIPSNYITEAED 61 Query: 145 SIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSV-SDFDNAKGLNVK 203 SI+ EWY +TR ++E+LL E G F+VR+S + G Y +SV + ++ Sbjct: 62 SIEMYEWYSKHMTRSQAEQLL-KQEGKEGGFIVRDS-SKAGKYTVSVFAKSTGEPQGVIR 119 Query: 204 HYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT---SKPQTQGLAK 260 HY + +Y+ + F+++ +L+ Y+ ++ GL RL + P T GL Sbjct: 120 HYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSKQNKNAPSTAGLGY 179 Query: 261 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKL 320 +WEI + L +LG G FG V G W G VAIK ++ G+MS + F++EA+VM L Sbjct: 180 GSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNL 239 Query: 321 RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 HEKLVQLY V +++ PI+I+TEYM+ G LL++L+ + + QL++M + M Y Sbjct: 240 SHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDVCEAMEY 298 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 +E ++HRDL A N LV + V KV+DFGL+R + D+EYT+ G+KFP++W+ PE +Y Sbjct: 299 LESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMY 358 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMC 499 +F+ KSD+W+FG+L+ E+ + G++PY N E + + +G R+ P E ++ +M Sbjct: 359 SKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMY 418 Query: 500 QCWRKEPEERPTFEYLQAFLED 521 CW ++ +ERP+F+ L + + D Sbjct: 419 SCWHEKADERPSFKILLSNILD 440 >1K9A-A nrPDB Length = 450 Score = 459 bits (1181), Expect = e-129, Method: Composition-based stats. Identities = 179/446 (40%), Positives = 248/446 (55%), Gaps = 24/446 (5%) Query: 87 TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSI 146 T +A Y++ E DL F KG+ L IV T+ W G+ G IP+NYV + + Sbjct: 12 TECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGV 71 Query: 147 QAE------EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGL 200 +A W+ GKITR ++ERLL E G FLVRES G Y L VS Sbjct: 72 KAGTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVSC-----EG 124 Query: 201 NVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTV--CPTSKPQTQGL 258 V+HY+I + I F +L QLV +Y+ ADGLC RL + Sbjct: 125 KVEHYRIM-YHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEF 183 Query: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 318 + W + + L+L +G+G FG+V +G + G +VA+K +K + +AFL EA VM Sbjct: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATA-QAFLAEASVMT 241 Query: 319 KLRHEKLVQLYAVVSEEP--IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 +LRH LVQL V+ EE +YIVTEYM+KGSL+D+L+ L L+ + + Sbjct: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 M Y+E N+VHRDL A N+LV E+ V KV+DFGL + + T K P+KWTAPEA Sbjct: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT----GKLPVKWTAPEA 357 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 +F+ KSDVWSFGILL E+ + GRVPYP + ++V+ +VE+GY+M P CP +++D Sbjct: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYD 417 Query: 497 LMCQCWRKEPEERPTFEYLQAFLEDY 522 +M CW + RPTF L+ LE Sbjct: 418 VMKNCWHLDAATRPTFLQLREQLEHI 443 >4XEY-B nrPDB Length = 408 Score = 450 bits (1158), Expect = e-127, Method: Composition-based stats. Identities = 171/389 (43%), Positives = 246/389 (63%), Gaps = 12/389 (3%) Query: 140 VAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKG 199 +A +S++ WY G ++R +E LL + N G+FLVRESE++ G +S+ Sbjct: 1 MASVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR-----YE 53 Query: 200 LNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQTQGL 258 V HY+I G Y++S ++FN+L +LV ++S ADGL L P +KP G+ Sbjct: 54 GRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGV 113 Query: 259 AKD--AWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQ 315 + + WE+ R + ++ KLG G +GEV+ G W + VA+KTLK TM E FL+EA Sbjct: 114 SPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA 173 Query: 316 VMKKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 374 VMK+++H LVQL V + EP YI+TE+M+ G+LLD+L+ + + L+ MA QI+ Sbjct: 174 VMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQIS 233 Query: 375 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 434 S M Y+E+ N++HRDL A N LVGEN + KVADFGL+RL+ + YTA GAKFPIKWTAP Sbjct: 234 SAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP 293 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESL 494 E+ Y +F+IKSDVW+FG+LL E+ T G PYPG+ +V + +E+ YRM P CPE + Sbjct: 294 ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV 353 Query: 495 HDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 ++LM CW+ P +RP+F + E F Sbjct: 354 YELMRACWQWNPSDRPSFAEIHQAFETMF 382 >5SYS-A nrPDB Length = 286 Score = 439 bits (1130), Expect = e-123, Method: Composition-based stats. Identities = 280/284 (98%), Positives = 281/284 (98%) Query: 253 PQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ 312 QTQGLAKDAWEIPRESLRLEVKLGQGCFGE WMGTWNGTTRVAIKTLKPGTMSPEAFLQ Sbjct: 3 MQTQGLAKDAWEIPRESLRLEVKLGQGCFGECWMGTWNGTTRVAIKTLKPGTMSPEAFLQ 62 Query: 313 EAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQ 372 EAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGE GKYLRLPQLVDMAAQ Sbjct: 63 EAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQ 122 Query: 373 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT 432 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT Sbjct: 123 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT 182 Query: 433 APEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE 492 APEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE Sbjct: 183 APEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE 242 Query: 493 SLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536 SLHDLMCQCWRK+PEERPTFEYLQAFLEDYFTSTEPQYQPGENL Sbjct: 243 SLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 286 >2DQ7-X nrPDB Length = 283 Score = 416 bits (1070), Expect = e-117, Method: Composition-based stats. Identities = 233/277 (84%), Positives = 258/277 (93%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKK 319 KD WEIPRESL+L +LG G FGEVWMGTWNG T+VAIKTLKPGTMSPE+FL+EAQ+MKK Sbjct: 1 KDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKK 60 Query: 320 LRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 L+H+KLVQLYAVVSEEPIYIVTEYM+KGSLLDFLK G+ L+LP LVDMAAQ+A+GMAY Sbjct: 61 LKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAY 120 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 +ERMNY+HRDLR+ANILVG L+CK+ADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY Sbjct: 121 IERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 180 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMC 499 GRFTIKSDVWSFGILLTEL TKGRVPYPGM NREVL+QVERGYRMPCP +CP SLH+LM Sbjct: 181 GRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMI 240 Query: 500 QCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536 CW+K+PEERPTFEYLQ+FLEDYFT+TEPQYQPGENL Sbjct: 241 HCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL 277 >2PL0-A nrPDB Length = 289 Score = 384 bits (986), Expect = e-107, Method: Composition-based stats. Identities = 185/284 (65%), Positives = 232/284 (81%) Query: 249 PTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPE 308 ++ + +D WE+PRE+L+L +LG G FGEVWMG +NG T+VA+K+LK G+MSP+ Sbjct: 4 MQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPD 63 Query: 309 AFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD 368 AFL EA +MK+L+H++LV+LYAVV++EPIYI+TEYM GSL+DFLK +G L + +L+D Sbjct: 64 AFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLD 123 Query: 369 MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFP 428 MAAQIA GMA++E NY+HRDLRAANILV + L CK+ADFGLARLIEDNEYTAR+GAKFP Sbjct: 124 MAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFP 183 Query: 429 IKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP 488 IKWTAPEA YG FTIKSDVWSFGILLTE+ T GR+PYPGM N EV+ +ERGYRM P Sbjct: 184 IKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPD 243 Query: 489 ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQP 532 CPE L+ LM CW++ PE+RPTF+YL++ LED+FT+TE QYQP Sbjct: 244 NCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTATEGQYQP 287 >4CSV-A nrPDB Length = 275 Score = 373 bits (959), Expect = e-104, Method: Composition-based stats. Identities = 172/265 (64%), Positives = 199/265 (75%), Gaps = 2/265 (0%) Query: 261 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKK 319 D WEIPR + LE KLG G FGEV+ G W VA+KTLK GTMS E FLQEAQ+MKK Sbjct: 4 DKWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSVEEFLQEAQIMKK 63 Query: 320 LRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378 L+H LVQLY V ++EP IYI+TEYMS GSLLD+L+ G + L+DMAAQ+ASGMA Sbjct: 64 LKHPNLVQLYGVCTKEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGMA 123 Query: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438 Y+E N++HRDL A N LVGEN V KVADFGLARLI ++EYTAR GAKFPIKWTAPEA Sbjct: 124 YLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTAPEAIS 183 Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM 498 Y RF+IKSDVW+FGILL E+ T G+VPYPGM EV++QVERGYRMP P CPE +++LM Sbjct: 184 YNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCPEEIYELM 243 Query: 499 CQCWRKEPEERPTFEYLQAFLEDYF 523 QCW K PEERPTF LE F Sbjct: 244 LQCWNKSPEERPTFAETLHALETMF 268 >2OZO-A nrPDB Length = 613 Score = 371 bits (952), Expect = e-103, Method: Composition-based stats. Identities = 140/459 (30%), Positives = 216/459 (47%), Gaps = 76/459 (16%) Query: 147 QAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYK 206 + WY +TR E+ER L + G FL+R + +G Y LS+ G V HY Sbjct: 159 ERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSL-----IYGKTVYHYL 212 Query: 207 IRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCP----------------- 249 I + +G + I T+F++L QLV Y ADGL + L CP Sbjct: 213 ISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSASNASGAAAPTLPA 272 Query: 250 -----------------------------TSKPQTQGLAKDAWEIPRES----------- 269 KP+ + +E P Sbjct: 273 HPSTLTHPQRRIDTLNSDGYTPEPARITSPDKPRPMPMDTSVFESPFSDPEELKDKKLFL 332 Query: 270 -----LRLEVKLGQGCFGEVWMGTWNGTTR---VAIKTLKPGTM--SPEAFLQEAQVMKK 319 L +++LG G FG V G + + VAIK LK GT E ++EAQ+M + Sbjct: 333 KRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQ 392 Query: 320 LRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 L + +V+L V E + +V E G L FL G+ + + + + ++ Q++ GM Y Sbjct: 393 LDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSMGMKY 451 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAA 437 +E N+VHR+L A N+L+ K++DFGL++ + +D+ YTAR K+P+KW APE Sbjct: 452 LEEKNFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECI 511 Query: 438 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDL 497 + +F+ +SDVWS+G+ + E + G+ PY M EV+ +E+G RM CPPECP L+ L Sbjct: 512 NFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYAL 571 Query: 498 MCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536 M CW + E+RP F ++ + + S + + G L Sbjct: 572 MSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEGGSAL 610 Score = 71.2 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 30/116 (25%), Positives = 47/116 (40%), Gaps = 6/116 (5%) Query: 143 SDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV 202 D +++G I+R E+E L A G FL+R+ + G Y LS+ Sbjct: 2 PDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFH---- 57 Query: 203 KHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC-PTSKPQTQG 257 H+ I + +G + I +L +YS+ DGL L C S + Q Sbjct: 58 -HFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQP 112 >3A4O-X nrPDB Length = 286 Score = 368 bits (946), Expect = e-102, Method: Composition-based stats. Identities = 183/277 (66%), Positives = 233/277 (84%), Gaps = 1/277 (0%) Query: 256 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQ 315 + KDAWEIPRES++L +LG G FGEVWMG +N +T+VA+KTLKPGTMS +AFL+EA Sbjct: 1 KPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEAN 60 Query: 316 VMKKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 374 +MK L+H+KLV+LYAVV+ EEPIYI+TEYM+KGSLLDFLK + G + LP+L+D +AQIA Sbjct: 61 LMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA 120 Query: 375 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 434 GMAY+ER NY+HRDLRAAN+LV E+L+CK+ADFGLAR+IEDNEYTAR+GAKFPIKWTAP Sbjct: 121 EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 180 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESL 494 EA +G FTIKSDVWSFGILL E+ T G++PYPG N +V+ + +GYRMP CP+ L Sbjct: 181 EAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDEL 240 Query: 495 HDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQ 531 +D+M CW+++ EERPTF+YLQ+ L+D++T+TE QYQ Sbjct: 241 YDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQ 277 >2HK5-A nrPDB Length = 270 Score = 367 bits (942), Expect = e-102, Method: Composition-based stats. Identities = 183/268 (68%), Positives = 225/268 (83%) Query: 255 TQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEA 314 + KDAWEIPRESL+LE KLG G FGEVWM T+N T+VA+KT+KPG+MS EAFL EA Sbjct: 2 QKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEA 61 Query: 315 QVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 374 VMK L+H+KLV+L+AVV++EPIYI+TE+M+KGSLLDFLK + G LP+L+D +AQIA Sbjct: 62 NVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIA 121 Query: 375 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 434 GMA++E+ NY+HRDLRAANILV +LVCK+ADFGLAR+IEDNEYTAR+GAKFPIKWTAP Sbjct: 122 EGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 181 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESL 494 EA +G FTIKSDVWSFGILL E+ T GR+PYPGM N EV+ +ERGYRMP P CPE L Sbjct: 182 EAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEEL 241 Query: 495 HDLMCQCWRKEPEERPTFEYLQAFLEDY 522 +++M +CW+ PEERPTFEY+Q+ L+D+ Sbjct: 242 YNIMMRCWKNRPEERPTFEYIQSVLDDF 269 >4E93-A nrPDB Length = 377 Score = 363 bits (931), Expect = e-100, Method: Composition-based stats. Identities = 144/382 (37%), Positives = 207/382 (54%), Gaps = 24/382 (6%) Query: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205 + + WY G I R E LL+++ G FLVRES+ K Y LSV +H+ Sbjct: 10 LHEQLWYHGAIPRAEVAELLVHS----GDFLVRESQG-KQEYVLSVLWDGLP-----RHF 59 Query: 206 KIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEI 265 I+ LD+ Y F S+ L+ + L + V + + KD W + Sbjct: 60 IIQSLDN--LYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVL------HRAVPKDKWVL 111 Query: 266 PRESLRLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLKPG--TMSPEAFLQEAQVMKKLRH 322 E L L ++G+G FGEV+ G T VA+K+ + FLQEA+++K+ H Sbjct: 112 NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSH 171 Query: 323 EKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 +V+L V + ++PIYIV E + G L FL+ E G LR+ L+ M A+GM Y+E Sbjct: 172 PNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE-GARLRVKTLLQMVGDAAAGMEYLE 230 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK-FPIKWTAPEAALYG 440 +HRDL A N LV E V K++DFG++R D Y A G + P+KWTAPEA YG Sbjct: 231 SKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYG 290 Query: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQ 500 R++ +SDVWSFGILL E + G PYP + N++ + VE+G R+PCP CP+++ LM Q Sbjct: 291 RYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQ 350 Query: 501 CWRKEPEERPTFEYLQAFLEDY 522 CW EP +RP+F + L+ Sbjct: 351 CWAYEPGQRPSFSTIYQELQSI 372 >6NPU-A nrPDB Length = 298 Score = 337 bits (864), Expect = 9e-93, Method: Composition-based stats. Identities = 130/267 (48%), Positives = 179/267 (67%), Gaps = 2/267 (0%) Query: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVM 317 D WE+ R + ++ KLG G +GEV+ G W + VA+KTLK TM E FL+EA VM Sbjct: 17 NYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVM 76 Query: 318 KKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 K+++H LVQL V + EP YI+TE+M+ G+LLD+L+ + + L+ MA QI+S Sbjct: 77 KEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSA 136 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 M Y+E+ N++HRDL A N LVGEN + KVADFGL+RL+ + YTA GAKFPIKWTAPE+ Sbjct: 137 MEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPES 196 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 Y +F+IKSDVW+FG+LL E+ T G PYPG+ +V + +E+ YRM P CPE +++ Sbjct: 197 LAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYE 256 Query: 497 LMCQCWRKEPEERPTFEYLQAFLEDYF 523 LM CW+ P +RP+F + E F Sbjct: 257 LMRACWQWNPSDRPSFAEIHQAFETMF 283 >2XYN-A nrPDB Length = 292 Score = 334 bits (857), Expect = 5e-92, Method: Composition-based stats. Identities = 134/268 (50%), Positives = 178/268 (66%), Gaps = 2/268 (0%) Query: 258 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQV 316 + D WE+ R + ++ KLG G +GEV++G W + VA+KTLK TM E FL+EA V Sbjct: 22 QSMDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAV 81 Query: 317 MKKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIAS 375 MK+++H LVQL V + E P YIVTEYM G+LLD+L+ + + L+ MA QI+S Sbjct: 82 MKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISS 141 Query: 376 GMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPE 435 M Y+E+ N++HRDL A N LVGEN V KVADFGL+RL+ + YTA GAKFPIKWTAPE Sbjct: 142 AMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPE 201 Query: 436 AALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLH 495 + Y F+IKSDVW+FG+LL E+ T G PYPG+ +V D +E+GYRM P CP ++ Sbjct: 202 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 261 Query: 496 DLMCQCWRKEPEERPTFEYLQAFLEDYF 523 +LM CW+ P +RP+F E F Sbjct: 262 ELMRACWKWSPADRPSFAETHQAFETMF 289 >5H2U-A nrPDB Length = 267 Score = 322 bits (825), Expect = 3e-88, Method: Composition-based stats. Identities = 139/262 (53%), Positives = 180/262 (68%), Gaps = 3/262 (1%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ-EAQVMKKLR 321 E PRE L KLG G FGEV+ G W +VAIK + + + LQ E Q MKKLR Sbjct: 1 MERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLR 60 Query: 322 HEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 H+ ++ LYAVVS +P+YI+TE M+KGSLL+ L+ K L + +L+D+A Q+A GM Y+ Sbjct: 61 HKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYL 120 Query: 381 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 440 E NY+HRDL A NILVGEN +CKV DFGLARLI+++ Y + P KWTAPEA G Sbjct: 121 ESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDH-NIPYKWTAPEALSRG 179 Query: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQ 500 ++ KSDVWSFGILL E+ ++G+VPYPGM N E +V+ GYRMPCP ECP S+H LM Sbjct: 180 HYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLT 239 Query: 501 CWRKEPEERPTFEYLQAFLEDY 522 CW ++PE+RPTF+ L+ L + Sbjct: 240 CWCRDPEQRPTFKALRERLSSF 261 >3DKO-A nrPDB Length = 318 Score = 316 bits (809), Expect = 2e-86, Method: Composition-based stats. Identities = 122/296 (41%), Positives = 168/296 (56%), Gaps = 10/296 (3%) Query: 242 HRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----VAI 297 + T + + + + A E+ +++E +G G FGEV G + VAI Sbjct: 17 TKTYIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAI 76 Query: 298 KTLKPG--TMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLK 354 KTLK G FL EA +M + H +V L VV+ +P+ IV E+M G+L FL+ Sbjct: 77 KTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLR 136 Query: 355 GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI 414 G+ + QLV M IA+GM Y+ M YVHRDL A NILV NLVCKV+DFGL+R+I Sbjct: 137 KHDGQ-FTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVI 195 Query: 415 EDN--EYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR 472 ED+ G K P++WTAPEA Y +FT SDVWS+GI++ E+ + G PY M N+ Sbjct: 196 EDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQ 255 Query: 473 EVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEP 528 +V+ +E GYR+P P +CP LH LM CW+KE ERP FE + L+ + Sbjct: 256 DVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKMIRNPNS 311 >4EBW-A nrPDB Length = 304 Score = 315 bits (806), Expect = 4e-86, Method: Composition-based stats. Identities = 109/285 (38%), Positives = 158/285 (55%), Gaps = 7/285 (2%) Query: 251 SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTW----NGTTRVAIKTLKPGTMS 306 G + +EI RE + L +G+G FG+V G + N VAIKT K T Sbjct: 21 YFQGAMGSSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSD 80 Query: 307 --PEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLP 364 E FLQEA M++ H +V+L V++E P++I+ E + G L FL+ L L Sbjct: 81 SVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYS-LDLA 139 Query: 365 QLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 424 L+ A Q+++ +AY+E +VHRD+ A N+LV N K+ DFGL+R +ED+ Y Sbjct: 140 SLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASK 199 Query: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484 K PIKW APE+ + RFT SDVW FG+ + E+ G P+ G+ N +V+ ++E G R+ Sbjct: 200 GKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERL 259 Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 P PP CP +L+ LM +CW +P RP F L+A L + Q Sbjct: 260 PMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQ 304 >2Y6O-A nrPDB Length = 291 Score = 313 bits (803), Expect = 8e-86, Method: Composition-based stats. Identities = 123/289 (42%), Positives = 171/289 (59%), Gaps = 10/289 (3%) Query: 255 TQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----VAIKTLKPGTMSPEA- 309 Q + + A EI +++E +G G FGEV G + VAIKTLK G + Sbjct: 1 NQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRR 60 Query: 310 -FLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLV 367 FL EA +M + H ++ L VV++ +P+ I+TEYM GSL FL+ G+ + QLV Sbjct: 61 DFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGR-FTVIQLV 119 Query: 368 DMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ--GA 425 M I SGM Y+ M+YVHRDL A NILV NLVCKV+DFG++R++ED+ A G Sbjct: 120 GMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGG 179 Query: 426 KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP 485 K PI+WTAPEA Y +FT SDVWS+GI++ E+ + G PY M N++V+ +E GYR+P Sbjct: 180 KIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLP 239 Query: 486 CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGE 534 P +CP +LH LM CW+KE +RP F + L+ + + G Sbjct: 240 PPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGS 288 >2R2P-A nrPDB Length = 295 Score = 313 bits (802), Expect = 1e-85, Method: Composition-based stats. Identities = 123/286 (43%), Positives = 169/286 (59%), Gaps = 10/286 (3%) Query: 250 TSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----VAIKTLKPG-- 303 T + Q + + A EI + +E +G G FGEV G + VAIKTLK G Sbjct: 4 TYEDPNQAVHEFAKEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYT 63 Query: 304 TMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLR 362 FL EA +M + H ++ L VV++ +P+ IVTEYM GSL FLK G+ Sbjct: 64 EKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQ-FT 122 Query: 363 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTAR 422 + QLV M I++GM Y+ M YVHRDL A NIL+ NLVCKV+DFGL+R++ED+ A Sbjct: 123 VIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAY 182 Query: 423 Q--GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480 G K PI+WTAPEA + +FT SDVWS+GI++ E+ + G PY M N++V+ VE Sbjct: 183 TTRGGKIPIRWTAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEE 242 Query: 481 GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 GYR+P P +CP +L+ LM CW+KE RP F+ + L+ + Sbjct: 243 GYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVNMLDKLIRNP 288 >1JPA-A nrPDB Length = 312 Score = 313 bits (801), Expect = 2e-85, Method: Composition-based stats. Identities = 122/291 (41%), Positives = 171/291 (58%), Gaps = 12/291 (4%) Query: 250 TSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----VAIKTLKPG-- 303 T + + + + A EI +++E +G G FGEV G + VAIKTLK G Sbjct: 15 TFEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYT 74 Query: 304 TMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLR 362 FL EA +M + H ++ L VV++ P+ I+TE+M GSL FL+ G+ Sbjct: 75 EKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQ-FT 133 Query: 363 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE---- 418 + QLV M IA+GM Y+ MNYVHRDL A NILV NLVCKV+DFGL+R +ED+ Sbjct: 134 VIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPT 193 Query: 419 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 YT+ G K PI+WTAPEA Y +FT SDVWS+GI++ E+ + G PY M N++V++ + Sbjct: 194 YTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAI 253 Query: 479 ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 E+ YR+P P +CP +LH LM CW+K+ RP F + L+ + Sbjct: 254 EQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSL 304 >4P5Q-A nrPDB Length = 361 Score = 312 bits (800), Expect = 2e-85, Method: Composition-based stats. Identities = 121/282 (42%), Positives = 171/282 (60%), Gaps = 10/282 (3%) Query: 254 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----VAIKTLKPG--TMSP 307 TQ + + A E+ ++ ++ +G G FGEV G ++ VAIKTLK G Sbjct: 19 STQTVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEKQR 78 Query: 308 EAFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQL 366 FL EA +M + H +++L VV++ +P+ IVTEYM GSL FL+ + + QL Sbjct: 79 RDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSFLRKHDAQ-FTVIQL 137 Query: 367 VDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ--G 424 V M IASGM Y+ M YVHRDL A NIL+ NLVCKV+DFGL+R++ED+ A G Sbjct: 138 VGMLRGIASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG 197 Query: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484 K PI+WT+PEA Y +FT SDVWS+GI+L E+ + G PY M N++V+ V+ GYR+ Sbjct: 198 GKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRL 257 Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 P P +CP +L+ LM CW+K+ RP FE + + L+ + Sbjct: 258 PPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILDKLIRNP 299 >4Y93-A nrPDB Length = 446 Score = 311 bits (796), Expect = 6e-85, Method: Composition-based stats. Identities = 114/279 (40%), Positives = 175/279 (62%), Gaps = 2/279 (0%) Query: 244 LTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPG 303 + + P T GL +WEI + L +LG G FG V G W G VAIK +K G Sbjct: 164 MGCQILAAAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEG 223 Query: 304 TMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLR 362 +MS + F++EA+VM L HEKLVQLY V +++ PI+I+TEYM+ G LL++L+ + + Sbjct: 224 SMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQ 282 Query: 363 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTAR 422 QL++M + M Y+E ++HRDL A N LV + V KV+DFG+ R + D+EYT+ Sbjct: 283 TQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSS 342 Query: 423 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY 482 G+KFP+KW +PE +Y +F+ KSD+W+FG+L+ E+ + G++PY N E + + +G Sbjct: 343 TGSKFPVKWASPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGL 402 Query: 483 RMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLED 521 R+P P E ++ +M CW ++ +ERPTF+ L + + D Sbjct: 403 RLPRPHLASERVYAIMYSCWHEKADERPTFKILLSNILD 441 >2J0K-A nrPDB Length = 656 Score = 309 bits (792), Expect = 2e-84, Method: Composition-based stats. Identities = 107/277 (38%), Positives = 156/277 (56%), Gaps = 7/277 (2%) Query: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTW----NGTTRVAIKTLKPGTMS--PEAFLQ 312 + +EI RE + L +G+G FG+V G + N VAIKT K T E FLQ Sbjct: 381 STRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQ 440 Query: 313 EAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQ 372 EA M++ H +V+L V++E P++I+ E + G L FL+ L L L+ A Q Sbjct: 441 EALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKFS-LDLASLILYAYQ 499 Query: 373 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT 432 +++ +AY+E +VHRD+ A N+LV K+ DFGL+R +ED+ Y K PIKW Sbjct: 500 LSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM 559 Query: 433 APEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE 492 APE+ + RFT SDVW FG+ + E+ G P+ G+ N +V+ ++E G R+P PP CP Sbjct: 560 APESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPP 619 Query: 493 SLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 +L+ LM +CW +P RP F L+A L + Q Sbjct: 620 TLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKLQ 656 >5MJB-A nrPDB Length = 305 Score = 308 bits (790), Expect = 3e-84, Method: Composition-based stats. Identities = 117/288 (40%), Positives = 170/288 (59%), Gaps = 12/288 (4%) Query: 253 PQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----VAIKTLKPG--TMS 306 + + + A EI +++E +G G FGEV+ G + VAIKTLK G Sbjct: 11 DPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQ 70 Query: 307 PEAFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQ 365 FL EA +M + H +++L VV++ P+ I+TE+M +L FL+ G+ + Q Sbjct: 71 RRDFLSEASIMGQFDHRNIIRLEGVVTKSRPVMIITEFMENCALDSFLRQNDGQ-FTVIQ 129 Query: 366 LVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE----YTA 421 LV M IA+GM Y+ MNYVHRDL A NILV NLVCKV+DFGL+R ++D+ YT+ Sbjct: 130 LVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTS 189 Query: 422 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481 G K P++WTAPEA Y +FT SDVWS+GI++ E+ + G PY M N++V++ +E+ Sbjct: 190 SLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQD 249 Query: 482 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 YR+P P +CP +LH LM CW+K+ RP F + L+ + Sbjct: 250 YRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASL 297 >6E4F-A nrPDB Length = 290 Score = 308 bits (790), Expect = 3e-84, Method: Composition-based stats. Identities = 112/272 (41%), Positives = 172/272 (63%), Gaps = 2/272 (0%) Query: 251 SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAF 310 T GL +WEI + L +LG G FG V G W G VAIK +K G+MS + F Sbjct: 14 YFQGTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEF 73 Query: 311 LQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDM 369 ++EA+VM L HEKLVQLY V +++ PI+I+TEYM+ G LL++L+ + + QL++M Sbjct: 74 IEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHR-FQTQQLLEM 132 Query: 370 AAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 429 + M Y+E ++HRDL A N LV + V KV+DFGL+R + D+EYT+ G+KFP+ Sbjct: 133 CKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPV 192 Query: 430 KWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE 489 +W+ PE +Y +F+ KSD+W+FG+L+ E+ + G++PY N E + + +G R+ P Sbjct: 193 RWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHL 252 Query: 490 CPESLHDLMCQCWRKEPEERPTFEYLQAFLED 521 E ++ +M CW ++ +ERPTF+ L + + D Sbjct: 253 ASEKVYTIMYSCWHEKADERPTFKILLSNILD 284 >5L6P-A nrPDB Length = 298 Score = 308 bits (788), Expect = 5e-84, Method: Composition-based stats. Identities = 121/290 (41%), Positives = 169/290 (58%), Gaps = 12/290 (4%) Query: 251 SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----VAIKTLKPG--T 304 S + + + A EI +++E +G G FGEV G R VAIKTLK G Sbjct: 2 SSDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTE 61 Query: 305 MSPEAFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRL 363 FL EA +M + H +++L VV++ P+ I+TE+M +L FL+ G+ + Sbjct: 62 RQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQ-FTV 120 Query: 364 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDN----EY 419 QLV M IA+GM Y+ MNYVHRDL A NILV NLVCKV+DFGL+R +ED+ Y Sbjct: 121 IQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTY 180 Query: 420 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE 479 T+ G K PI+WTAPEA Y +FT SDVWS+GI++ E+ + G PY M N++V++ VE Sbjct: 181 TSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVE 240 Query: 480 RGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 + YR+P P +CP +LH LM CW ++ RP F + L+ + Sbjct: 241 QDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNPASL 290 >2VWV-A nrPDB Length = 302 Score = 305 bits (781), Expect = 4e-83, Method: Composition-based stats. Identities = 119/288 (41%), Positives = 169/288 (58%), Gaps = 12/288 (4%) Query: 253 PQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----VAIKTLKPG--TMS 306 + + + A EI +++E +G G FGEV G + VAIKTLK G Sbjct: 1 DPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQ 60 Query: 307 PEAFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQ 365 FL EA +M + H +++L VV+ P+ I+TE+M G+L FL+ G+ + Q Sbjct: 61 RREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQ-FTVIQ 119 Query: 366 LVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEY----TA 421 LV M IASGM Y+ M+YVHRDL A NILV NLVCKV+DFGL+R +E+N T+ Sbjct: 120 LVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETS 179 Query: 422 RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481 G K PI+WTAPEA + +FT SD WS+GI++ E+ + G PY M N++V++ +E+ Sbjct: 180 SLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQD 239 Query: 482 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 YR+P PP+CP SLH LM CW+K+ RP F + + L+ + Sbjct: 240 YRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASL 287 >3QGY-A nrPDB Length = 286 Score = 304 bits (778), Expect = 8e-83, Method: Composition-based stats. Identities = 110/259 (42%), Positives = 159/259 (61%), Gaps = 2/259 (0%) Query: 262 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR 321 I L ++G G FG V +G W +VAIKT+K G+MS + F++EA+VM KL Sbjct: 21 HMVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIKEGSMSEDDFIEEAEVMMKLS 80 Query: 322 HEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 H KLVQLY V E+ PI +V E+M G L D+L+ + G L+ M + GMAY+ Sbjct: 81 HPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRG-LFAAETLLGMCLDVCEGMAYL 139 Query: 381 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 440 E +HRDL A N LVGEN V KV+DFG+ R + D++YT+ G KFP+KW +PE + Sbjct: 140 EEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFS 199 Query: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQ 500 R++ KSDVWSFG+L+ E+ ++G++PY N EV++ + G+R+ P ++ +M Sbjct: 200 RYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNH 259 Query: 501 CWRKEPEERPTFEYLQAFL 519 CW++ PE+RP F L L Sbjct: 260 CWKERPEDRPAFSRLLRQL 278 >3SXS-A nrPDB Length = 268 Score = 303 bits (776), Expect = 1e-82, Method: Composition-based stats. Identities = 117/268 (43%), Positives = 172/268 (64%), Gaps = 2/268 (0%) Query: 262 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR 321 E+ RE + L +LG G FG V +G W G VA+K +K G+MS + F QEAQ M KL Sbjct: 2 HMELKREEITLLKELGSGQFGVVKLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLS 61 Query: 322 HEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 H KLV+ Y V S+E PIYIVTEY+S G LL++L+ GK L QL++M + GMA++ Sbjct: 62 HPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSH-GKGLEPSQLLEMCYDVCEGMAFL 120 Query: 381 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 440 E ++HRDL A N LV +L KV+DFG+ R + D++Y + G KFP+KW+APE Y Sbjct: 121 ESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYF 180 Query: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQ 500 +++ KSDVW+FGIL+ E+ + G++PY N EV+ +V +G+R+ P ++++ +M Sbjct: 181 KYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQIMYS 240 Query: 501 CWRKEPEERPTFEYLQAFLEDYFTSTEP 528 CW + PE+RPTF+ L + +E + Sbjct: 241 CWHELPEKRPTFQQLLSSIEPLREKDKH 268 >4H1J-A nrPDB Length = 293 Score = 301 bits (771), Expect = 5e-82, Method: Composition-based stats. Identities = 101/275 (36%), Positives = 150/275 (54%), Gaps = 7/275 (2%) Query: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNG----TTRVAIKTLKPGT--MSPEAFLQ 312 + I RE + L LG+G FGEV+ G + VA+KT K + E F+ Sbjct: 15 GSPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMS 74 Query: 313 EAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQ 372 EA +MK L H +V+L ++ EEP +I+ E G L +L+ L++ LV + Q Sbjct: 75 EAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNS-LKVLTLVLYSLQ 133 Query: 373 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT 432 I MAY+E +N VHRD+ NILV K+ DFGL+R IED +Y + PIKW Sbjct: 134 ICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWM 193 Query: 433 APEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE 492 +PE+ + RFT SDVW F + + E+ + G+ P+ + N++V+ +E+G R+P P CP Sbjct: 194 SPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPP 253 Query: 493 SLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE 527 L+ LM +CW +P +RP F L L D + + Sbjct: 254 VLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEK 288 >1BYG-A nrPDB Length = 278 Score = 301 bits (770), Expect = 7e-82, Method: Composition-based stats. Identities = 116/276 (42%), Positives = 167/276 (60%), Gaps = 8/276 (2%) Query: 251 SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAF 310 S + W + + L+L +G+G FG+V +G + G +VA+K +K + +AF Sbjct: 4 SVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATA-QAF 61 Query: 311 LQEAQVMKKLRHEKLVQLYAVVSEEP--IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD 368 L EA VM +LRH LVQL V+ EE +YIVTEYM+KGSL+D+L+ L L+ Sbjct: 62 LAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLK 121 Query: 369 MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFP 428 + + M Y+E N+VHRDL A N+LV E+ V KV+DFGL + + T K P Sbjct: 122 FSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT----GKLP 177 Query: 429 IKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP 488 +KWTAPEA +F+ KSDVWSFGILL E+ + GRVPYP + ++V+ +VE+GY+M P Sbjct: 178 VKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPD 237 Query: 489 ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFT 524 CP +++++M CW + RP+F L+ LE T Sbjct: 238 GCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKT 273 >3KUL-B nrPDB Length = 325 Score = 300 bits (769), Expect = 8e-82, Method: Composition-based stats. Identities = 115/275 (41%), Positives = 155/275 (56%), Gaps = 10/275 (3%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----VAIKTLKPG--TMSPEAFLQEAQVM 317 EI + +E +G G GEV G + VAIK LK G FL EA +M Sbjct: 45 EIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALKAGYTERQRRDFLSEASIM 104 Query: 318 KKLRHEKLVQLYAVVSEEPI-YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 + H +++L VV+ + IVTEYM GSL FL+ G+ + QLV M + +G Sbjct: 105 GQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQ-FTIMQLVGMLRGVGAG 163 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEY--TARQGAKFPIKWTAP 434 M Y+ + YVHRDL A N+LV NLVCKV+DFGL+R++ED+ G K PI+WTAP Sbjct: 164 MRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWTAP 223 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESL 494 EA + F+ SDVWSFG+++ E+ G PY M NR+V+ VE GYR+P P CP +L Sbjct: 224 EAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRLPAPMGCPHAL 283 Query: 495 HDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 H LM CW K+ +RP F + + L+ S E Sbjct: 284 HQLMLDCWHKDRAQRPRFSQIVSVLDALIRSPESL 318 >4PDO-A nrPDB Length = 299 Score = 299 bits (766), Expect = 2e-81, Method: Composition-based stats. Identities = 120/285 (42%), Positives = 170/285 (59%), Gaps = 11/285 (3%) Query: 250 TSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT-----RVAIKTLKPGT 304 T + Q + K EI + + +G G FGEV+ G ++ VAIKTLK G Sbjct: 16 TYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGY 75 Query: 305 MSPEA--FLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYL 361 + FL EA +M + H +++L V+S+ +P+ I+TEYM G+L FL+ + G+ Sbjct: 76 TEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDGE-F 134 Query: 362 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA 421 + QLV M IA+GM Y+ MNYVHRDL A NILV NLVCKV+DFGL+R++ED+ Sbjct: 135 SVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEAT 194 Query: 422 RQ--GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE 479 G K PI+WTAPEA Y +FT SDVWSFGI++ E+ T G PY + N EV+ + Sbjct: 195 YTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAIN 254 Query: 480 RGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFT 524 G+R+P P +CP +++ LM QCW++E RP F + + L+ Sbjct: 255 DGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIR 299 >4XCU-A nrPDB Length = 300 Score = 298 bits (763), Expect = 5e-81, Method: Composition-based stats. Identities = 110/285 (38%), Positives = 156/285 (54%), Gaps = 18/285 (6%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMG--------TWNGTTRVAIKTLKPGTMSPE--A 309 WE PR+ L L LG+GCFG+V + + VA+K LK + Sbjct: 9 DPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLAD 68 Query: 310 FLQEAQVMKKL-RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGK-----YLR 362 + E +VMK + RH+ ++ L V ++E P+Y++ E +KG+L +FL+ L Sbjct: 69 LVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLS 128 Query: 363 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTAR 422 P LV A Q+A GM Y+E +HRDL A N+LV E+ V K+ADFGLAR + +Y + Sbjct: 129 FPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKK 188 Query: 423 QG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481 + P+KW APEA +T +SDVWSFGILL E+ T G PYPG+ E+ + G Sbjct: 189 TSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREG 248 Query: 482 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 +RM PP CP L+ LM +CW P +RPTF+ L L+ + Sbjct: 249 HRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAV 293 >3TT0-A nrPDB Length = 382 Score = 297 bits (760), Expect = 8e-81, Method: Composition-based stats. Identities = 108/314 (34%), Positives = 160/314 (50%), Gaps = 28/314 (8%) Query: 244 LTTVCPTSKPQTQGLAKDA-WEIPRESLRLEVKLGQGCFGEVWMGTW--------NGTTR 294 L + L +D WE+PR+ L L LG+G FG+V + N T+ Sbjct: 44 LYFQGMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTK 103 Query: 295 VAIKTLKPGTMSPE--AFLQEAQVMKKL-RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLL 350 VA+K LK + + E ++MK + +H+ ++ L +++ P+Y++ EY SKG+L Sbjct: 104 VAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLR 163 Query: 351 DFLKGETGKYL--------------RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANIL 396 ++L+ L LV A Q+A GM Y+ +HRDL A N+L Sbjct: 164 EYLQARRPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVL 223 Query: 397 VGENLVCKVADFGLARLIEDNEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILL 455 V E+ V K+ADFGLAR I +Y + + P+KW APEA +T +SDVWSFG+LL Sbjct: 224 VTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLL 283 Query: 456 TELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYL 515 E+ T G PYPG+ E+ ++ G+RM P C L+ +M CW P +RPTF+ L Sbjct: 284 WEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQL 343 Query: 516 QAFLEDYFTSTEPQ 529 L+ T Q Sbjct: 344 VEDLDRIVALTSNQ 357 >6GQK-A nrPDB Length = 328 Score = 296 bits (757), Expect = 2e-80, Method: Composition-based stats. Identities = 104/301 (34%), Positives = 156/301 (51%), Gaps = 26/301 (8%) Query: 250 TSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR------VAIKTLKPG 303 + TQ WE PR L LG G FG+V T G + VA+K LKP Sbjct: 23 SYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPS 82 Query: 304 --TMSPEAFLQEAQVMKKL-RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGK 359 + EA + E +V+ L HE +V L + P ++TEY G LL+FL+ + + Sbjct: 83 AHSTEREALMSELKVLSYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDE 142 Query: 360 Y--------------LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKV 405 + L L L+ + Q+A GMA++ N +HRDL A NIL+ + K+ Sbjct: 143 FVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKI 202 Query: 406 ADFGLARLIEDNE-YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRV 464 DFGLAR I+++ Y + A+ P+KW APE+ +T +SDVWS+GI L EL + G Sbjct: 203 CDFGLARDIKNDSNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSS 262 Query: 465 PYPGMV-NREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 PYPGM + + ++ G+RM P P ++D+M CW +P++RPTF+ + +E Sbjct: 263 PYPGMPVDSKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIVQDIEKQI 322 Query: 524 T 524 + Sbjct: 323 S 323 >3GQL-A nrPDB Length = 326 Score = 295 bits (756), Expect = 3e-80, Method: Composition-based stats. Identities = 105/297 (35%), Positives = 155/297 (52%), Gaps = 27/297 (9%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMGTW--------NGTTRVAIKTLKPGTMSPE--A 309 WE+PR+ L L LG+G FG+V + N T+VA+K LK + Sbjct: 20 DPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSD 79 Query: 310 FLQEAQVMKKL-RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYL------ 361 + E ++MK + +H+ ++ L +++ P+Y++ EY SKG+L ++L+ L Sbjct: 80 LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNP 139 Query: 362 --------RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARL 413 LV A Q+A GM Y+ +HRDL A N+LV E+ V K+ADFGLAR Sbjct: 140 SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARD 199 Query: 414 IEDNEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR 472 I +Y + + P+KW APEA +T +SDVWSFG+LL E+ T G PYPG+ Sbjct: 200 IHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVE 259 Query: 473 EVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 E+ ++ G+RM P C L+ +M CW P +RPTF+ L L+ T Q Sbjct: 260 ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 316 >4AT3-A nrPDB Length = 299 Score = 295 bits (755), Expect = 4e-80, Method: Composition-based stats. Identities = 96/290 (33%), Positives = 161/290 (55%), Gaps = 20/290 (6%) Query: 257 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGT------WNGTTRVAIKTLKPGTMS-PEA 309 + I R ++ L+ +LG+G FG+V++ VA+KTLK + + + Sbjct: 2 AMDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKD 61 Query: 310 FLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGE-----------T 357 F +EA+++ L+HE +V+ Y V E +P+ +V EYM G L FL+ Sbjct: 62 FHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNP 121 Query: 358 GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDN 417 L Q++ +A QIA+GM Y+ ++VHRDL N LVGENL+ K+ DFG++R + Sbjct: 122 PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYST 181 Query: 418 EYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLD 476 +Y G PI+W PE+ +Y +FT +SDVWS G++L E+ T G+ P+ + N EV++ Sbjct: 182 DYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIE 241 Query: 477 QVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 + +G + P CP+ +++LM CW++EP R + + L++ ++ Sbjct: 242 CITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKAS 291 >3V5Q-A nrPDB Length = 297 Score = 294 bits (753), Expect = 6e-80, Method: Composition-based stats. Identities = 97/296 (32%), Positives = 161/296 (54%), Gaps = 23/296 (7%) Query: 254 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTW------NGTTRVAIKTLKPGTMS- 306 I R + L+ +LG+G FG+V++ VA+K LK T++ Sbjct: 1 GAMHSGIHVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA 60 Query: 307 PEAFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYL---- 361 + F +EA+++ L+HE +V+ Y V + +P+ +V EYM G L FL+ + Sbjct: 61 RKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVD 120 Query: 362 ----------RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLA 411 L Q++ +A+QIASGM Y+ ++VHRDL N LVG NL+ K+ DFG++ Sbjct: 121 GQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMS 180 Query: 412 RLIEDNEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMV 470 R + +Y G PI+W PE+ +Y +FT +SDVWSFG++L E+ T G+ P+ + Sbjct: 181 RDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLS 240 Query: 471 NREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 N EV++ + +G + P CP+ ++D+M CW++EP++R + + L +T Sbjct: 241 NTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKAT 296 >2PSQ-A nrPDB Length = 370 Score = 294 bits (752), Expect = 7e-80, Method: Composition-based stats. Identities = 104/294 (35%), Positives = 154/294 (52%), Gaps = 27/294 (9%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR--------VAIKTLKPGTMSPE--A 309 WE PR+ L L LG+GCFG+V M G + VA+K LK + Sbjct: 73 DPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSD 132 Query: 310 FLQEAQVMKKL-RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYL------ 361 + E ++MK + +H+ ++ L +++ P+Y++ EY SKG+L ++L+ + Sbjct: 133 LVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDI 192 Query: 362 --------RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARL 413 LV Q+A GM Y+ +HRDL A N+LV EN V K+ADFGLAR Sbjct: 193 NRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARD 252 Query: 414 IEDNEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR 472 I + +Y + + P+KW APEA +T +SDVWSFG+L+ E+ T G PYPG+ Sbjct: 253 INNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 312 Query: 473 EVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 E+ ++ G+RM P C L+ +M CW P +RPTF+ L L+ T T Sbjct: 313 ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLT 366 >5A46-A nrPDB Length = 386 Score = 294 bits (752), Expect = 8e-80, Method: Composition-based stats. Identities = 106/297 (35%), Positives = 156/297 (52%), Gaps = 27/297 (9%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMGTW--------NGTTRVAIKTLKPGTMSPE--A 309 WE+PR+ L L LG+GCFG+V + N T+VA+K LK + Sbjct: 32 DPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSD 91 Query: 310 FLQEAQVMKKL-RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYL------ 361 + E ++MK + +H+ ++ L +++ P+Y++ EY SKG+L ++L+ L Sbjct: 92 LISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNP 151 Query: 362 --------RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARL 413 LV A Q+A GM Y+ +HRDL A N+LV E+ V K+ADFGLAR Sbjct: 152 SHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARD 211 Query: 414 IEDNEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR 472 I +Y + + P+KW APEA +T +SDVWSFG+LL E+ T G PYPG+ Sbjct: 212 IHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVE 271 Query: 473 EVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 E+ ++ G+RM P C L+ +M CW P +RPTF+ L L+ T Q Sbjct: 272 ELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 328 >4K33-A nrPDB Length = 325 Score = 292 bits (747), Expect = 3e-79, Method: Composition-based stats. Identities = 103/294 (35%), Positives = 152/294 (51%), Gaps = 27/294 (9%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR--------VAIKTLKPGTMSPE--A 309 WE+ R L L LG+G FG+V M G + VA+K LK + Sbjct: 28 DPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSD 87 Query: 310 FLQEAQVMKKL-RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLR----- 362 + E ++MK + +H+ ++ L ++ P+Y++ EY +KG+L +FL+ L Sbjct: 88 LVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDT 147 Query: 363 ---------LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARL 413 LV A Q+A GM Y+ +HRDL A N+LV E+ V K+ADFGLAR Sbjct: 148 SKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARD 207 Query: 414 IED-NEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR 472 + + + Y + P+KW APEA +T +SDVWSFG+LL E+ T G PYPG+ Sbjct: 208 VHNLDYYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVE 267 Query: 473 EVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 E+ ++ G+RM P C L+ +M +CW P +RPTF+ L L+ T T Sbjct: 268 ELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVT 321 >2OGV-A nrPDB Length = 317 Score = 290 bits (742), Expect = 1e-78, Method: Composition-based stats. Identities = 109/315 (34%), Positives = 173/315 (54%), Gaps = 31/315 (9%) Query: 227 QQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVW- 285 +++ Y ++ T + PT P + WE PR +L+ LG G FG+V Sbjct: 8 WKIIESYEGNS------YTFIDPTQLPYNE-----KWEFPRNNLQFGKTLGAGAFGKVVE 56 Query: 286 -----MGTWNGTTRVAIKTLKPGT--MSPEAFLQEAQVMKKL-RHEKLVQLYAVVSEE-P 336 +G + +VA+K LK EA + E ++M L +HE +V L + P Sbjct: 57 ATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGP 116 Query: 337 IYIVTEYMSKGSLLDFLKG--------ETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 + ++TEY G LL+FL+ E G+ L L L+ ++Q+A GMA++ N +HR Sbjct: 117 VLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHR 176 Query: 389 DLRAANILVGENLVCKVADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 447 D+ A N+L+ V K+ DFGLAR ++ D+ Y + A+ P+KW APE+ +T++SD Sbjct: 177 DVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSD 236 Query: 448 VWSFGILLTELTTKGRVPYPG-MVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEP 506 VWS+GILL E+ + G PYPG +VN + V+ GY+M P P++++ +M CW EP Sbjct: 237 VWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEP 296 Query: 507 EERPTFEYLQAFLED 521 RPTF+ + +FL++ Sbjct: 297 THRPTFQQICSFLQE 311 >5EG3-A nrPDB Length = 334 Score = 288 bits (738), Expect = 4e-78, Method: Composition-based stats. Identities = 103/299 (34%), Positives = 155/299 (51%), Gaps = 28/299 (9%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR--------VAIKTLKPGTMSPE--A 309 WE PR+ L L LG+G FG+V M G + VA+K LK + Sbjct: 27 DPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSD 86 Query: 310 FLQEAQVMKKL-RHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRL---- 363 + E ++MK + +H+ ++ L +++ P+Y++ Y SKG+L ++L+ + L Sbjct: 87 LVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVAYASKGNLREYLRARRPPGMELSPDI 146 Query: 364 ----------PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARL 413 LV Q+A GM Y+ +HRDL A N+LV EN V K+ADFGLAR Sbjct: 147 NRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARD 206 Query: 414 IEDNEY-TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR 472 I + ++ + P+KW APEA +T +SDVWSFG+L+ E+ T G PYPG+ Sbjct: 207 INNIDFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVE 266 Query: 473 EVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFT-STEPQY 530 E+ ++ G+RM P C L+ +M CW P +RPTF+ L L+ T +T +Y Sbjct: 267 ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEY 325 >5U6B-A nrPDB Length = 307 Score = 288 bits (737), Expect = 4e-78, Method: Composition-based stats. Identities = 104/288 (36%), Positives = 154/288 (53%), Gaps = 18/288 (6%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNGTT---RVAIKTLKPGTMSP---EAFLQEAQVMK 318 + R + L LG+G FG V G N +VA+KT+K + E FL EA MK Sbjct: 20 VDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMK 79 Query: 319 KLRHEKLVQLYAVV----SEEPI---YIVTEYMSKGSLLDFLK----GETGKYLRLPQLV 367 + H +++L V E ++ +M G L FL G+ YL LV Sbjct: 80 EFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLV 139 Query: 368 DMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG-AK 426 A IASGM Y+ ++HRDL A N ++ EN+ VADFGL++ I + +Y + AK Sbjct: 140 KFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAK 199 Query: 427 FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPC 486 P+KW A E+ +T KSDVWSFG+ + E+ T+G+ PYPG+ N E+ D + +G R+ Sbjct: 200 MPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQ 259 Query: 487 PPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGE 534 P +C + L+ LM +CW P++RP+F L+ LE+ + P +P E Sbjct: 260 PADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDE 307 >4HZS-A nrPDB Length = 341 Score = 288 bits (736), Expect = 5e-78, Method: Composition-based stats. Identities = 105/266 (39%), Positives = 153/266 (57%), Gaps = 12/266 (4%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWN----GTTRVAIKTLKPGTMSP----EAFLQEAQV 316 I + LRL KLG G FG V G W+ T VA+K LKP +S + F++E Sbjct: 9 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 68 Query: 317 MKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 M L H L++LY VV P+ +VTE GSLLD L+ G +L L L A Q+A G Sbjct: 69 MHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQVAEG 127 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE--DNEYTARQGAKFPIKWTAP 434 M Y+E ++HRDL A N+L+ + K+ DFGL R + D+ Y ++ K P W AP Sbjct: 128 MGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 187 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER-GYRMPCPPECPES 493 E+ F+ SD W FG+ L E+ T G+ P+ G+ ++L ++++ G R+P P +CP+ Sbjct: 188 ESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 247 Query: 494 LHDLMCQCWRKEPEERPTFEYLQAFL 519 ++++M QCW +PE+RPTF L+ FL Sbjct: 248 IYNVMVQCWAHKPEDRPTFVALRDFL 273 Score = 44.6 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 15/70 (21%), Positives = 26/70 (37%), Gaps = 3/70 (4%) Query: 82 LAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD-WWLAHSLSTGQTGYIPSNYV 140 L T AL D+E L + + + ++ + WW + T G P N V Sbjct: 274 LEAQPTDMRALQDFE--EPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCVGPFPRNVV 331 Query: 141 APSDSIQAEE 150 + A++ Sbjct: 332 TSVAGLSAQD 341 >1U54-B nrPDB Length = 291 Score = 288 bits (736), Expect = 6e-78, Method: Composition-based stats. Identities = 105/266 (39%), Positives = 153/266 (57%), Gaps = 12/266 (4%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWN----GTTRVAIKTLKPGTMSP----EAFLQEAQV 316 I + LRL KLG G FG V G W+ T VA+K LKP +S + F++E Sbjct: 15 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA 74 Query: 317 MKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 M L H L++LY VV P+ +VTE GSLLD L+ G +L L L A Q+A G Sbjct: 75 MHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFL-LGTLSRYAVQVAEG 133 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE--DNEYTARQGAKFPIKWTAP 434 M Y+E ++HRDL A N+L+ + K+ DFGL R + D+ Y ++ K P W AP Sbjct: 134 MGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAP 193 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER-GYRMPCPPECPES 493 E+ F+ SD W FG+ L E+ T G+ P+ G+ ++L ++++ G R+P P +CP+ Sbjct: 194 ESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQD 253 Query: 494 LHDLMCQCWRKEPEERPTFEYLQAFL 519 ++++M QCW +PE+RPTF L+ FL Sbjct: 254 IYNVMVQCWAHKPEDRPTFVALRDFL 279 >4XLV-A nrPDB Length = 328 Score = 288 bits (736), Expect = 6e-78, Method: Composition-based stats. Identities = 108/303 (35%), Positives = 156/303 (51%), Gaps = 18/303 (5%) Query: 245 TTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNG------TTRVAIK 298 + + + D WE+ RE + L +LGQG FG V+ G TRVA+K Sbjct: 16 EYLSASDVFPSSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVK 75 Query: 299 TLKPGTMSPEA--FLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKG 355 T+ E FL EA VMK +V+L VVS+ +P +V E M+ G L +L+ Sbjct: 76 TVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRS 135 Query: 356 ETGK--------YLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVAD 407 + L +++ MAA+IA GMAY+ +VHRDL A N +V + K+ D Sbjct: 136 LRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGD 195 Query: 408 FGLARLIEDNEYTARQGAKF-PIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPY 466 FG+ R I + +Y + G P++W APE+ G FT SD+WSFG++L E+T+ PY Sbjct: 196 FGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPY 255 Query: 467 PGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 G+ N +VL V G + P CPE + DLM CW+ P RPTF + L+D + Sbjct: 256 QGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPS 315 Query: 527 EPQ 529 P+ Sbjct: 316 FPE 318 >5AMN-A nrPDB Length = 299 Score = 285 bits (730), Expect = 3e-77, Method: Composition-based stats. Identities = 107/285 (37%), Positives = 156/285 (54%), Gaps = 18/285 (6%) Query: 256 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGT---WNGT---TRVAIKTLKPGTMSPE- 308 + L WE PR++L L LG+G FG+V T G T VA+K LK E Sbjct: 11 KILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSEL 70 Query: 309 -AFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETG-------- 358 L E V+K++ H +++LY S++ P+ ++ EY GSL FL+ Sbjct: 71 RDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDE 130 Query: 359 KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI-EDN 417 + L + L+ A QI+ GM Y+ M VHRDL A NILV E K++DFGL+R + E++ Sbjct: 131 RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEED 190 Query: 418 EYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQ 477 Y R + P+KW A E+ +T +SDVWSFG+LL E+ T G PYPG+ + + Sbjct: 191 SYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNL 250 Query: 478 VERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 ++ G+RM P C E ++ LM QCW++EP++RP F + LE Sbjct: 251 LKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM 295 >3BEA-A nrPDB Length = 333 Score = 285 bits (730), Expect = 3e-77, Method: Composition-based stats. Identities = 106/319 (33%), Positives = 171/319 (53%), Gaps = 35/319 (10%) Query: 227 QQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVW- 285 +++ Y ++ T + PT P + WE PR +L+ LG G FG+V Sbjct: 16 WKIIESYEGNS------YTFIDPTQLPYNE-----KWEFPRNNLQFGKTLGAGAFGKVVE 64 Query: 286 -----MGTWNGTTRVAIKTLKPGT--MSPEAFLQEAQVMKKL-RHEKLVQLYAVVSEE-P 336 +G + +VA+K LK EA + E ++M L +HE +V L + P Sbjct: 65 ATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGP 124 Query: 337 IYIVTEYMSKGSLLDFLKGET------------GKYLRLPQLVDMAAQIASGMAYVERMN 384 + ++TEY G LL+FL+ ++ L L+ ++Q+A GMA++ N Sbjct: 125 VLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKN 184 Query: 385 YVHRDLRAANILVGENLVCKVADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443 +HRD+ A N+L+ V K+ DFGLAR ++ D+ Y + A+ P+KW APE+ +T Sbjct: 185 CIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYT 244 Query: 444 IKSDVWSFGILLTELTTKGRVPYPG-MVNREVLDQVERGYRMPCPPECPESLHDLMCQCW 502 ++SDVWS+GILL E+ + G PYPG +VN + V+ GY+M P P++++ +M CW Sbjct: 245 VQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACW 304 Query: 503 RKEPEERPTFEYLQAFLED 521 EP RPTF+ + +FL++ Sbjct: 305 ALEPTHRPTFQQICSFLQE 323 >3KRL-A nrPDB Length = 335 Score = 285 bits (729), Expect = 4e-77, Method: Composition-based stats. Identities = 106/321 (33%), Positives = 170/321 (52%), Gaps = 37/321 (11%) Query: 227 QQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVW- 285 +++ Y ++ T + PT P + WE PR +L+ LG G FG+V Sbjct: 16 WKIIESYEGNS------YTFIDPTQLPYNE-----KWEFPRNNLQFGKTLGAGAFGKVVE 64 Query: 286 -----MGTWNGTTRVAIKTLKPGT--MSPEAFLQEAQVMKKL-RHEKLVQLYAVVSEE-P 336 +G + +VA+K LK EA + E ++M L +HE +V L + P Sbjct: 65 ATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGP 124 Query: 337 IYIVTEYMSKGSLLDFLKGETGKYL--------------RLPQLVDMAAQIASGMAYVER 382 + ++TEY G LL+FL+ + L L+ ++Q+A GMA++ Sbjct: 125 VLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLAS 184 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALYGR 441 N +HRD+ A N+L+ V K+ DFGLAR ++ D+ Y + A+ P+KW APE+ Sbjct: 185 KNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCV 244 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPG-MVNREVLDQVERGYRMPCPPECPESLHDLMCQ 500 +T++SDVWS+GILL E+ + G PYPG +VN + V+ GY+M P P++++ +M Sbjct: 245 YTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQA 304 Query: 501 CWRKEPEERPTFEYLQAFLED 521 CW EP RPTF+ + +FL++ Sbjct: 305 CWALEPTHRPTFQQICSFLQE 325 >4R7H-A nrPDB Length = 343 Score = 284 bits (728), Expect = 5e-77, Method: Composition-based stats. Identities = 109/328 (33%), Positives = 174/328 (53%), Gaps = 44/328 (13%) Query: 227 QQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVW- 285 +++ Y ++ T + PT P + WE PR +L+ LG G FG+V Sbjct: 20 WKIIESYEGNS------YTFIDPTQLPYNE-----KWEFPRNNLQFGKTLGAGAFGKVVE 68 Query: 286 -----MGTWNGTTRVAIKTLKPGT--MSPEAFLQEAQVMKKL-RHEKLVQLYAVVSEE-P 336 +G + +VA+K LK EA + E ++M L +HE +V L + P Sbjct: 69 ATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGP 128 Query: 337 IYIVTEYMSKGSLLDFLKG---------------------ETGKYLRLPQLVDMAAQIAS 375 + ++TEY + G LL+FL+ E G+ L L L+ ++Q+A Sbjct: 129 VLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQ 188 Query: 376 GMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR-LIEDNEYTARQGAKFPIKWTAP 434 GMA++ N +HRD+ A N+L+ V K+ DFGLAR ++ D+ Y + A+ P+KW AP Sbjct: 189 GMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAP 248 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPG-MVNREVLDQVERGYRMPCPPECPES 493 E+ +T++SDVWS+GILL E+ + G PYPG +VN + V+ GY+M P P++ Sbjct: 249 ESIFDSVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKN 308 Query: 494 LHDLMCQCWRKEPEERPTFEYLQAFLED 521 ++ +M CW EP RPTF+ + +FL++ Sbjct: 309 IYSIMQACWALEPTHRPTFQQITSFLQE 336 >1U59-A nrPDB Length = 287 Score = 284 bits (727), Expect = 7e-77, Method: Composition-based stats. Identities = 99/276 (35%), Positives = 160/276 (57%), Gaps = 9/276 (3%) Query: 265 IPRESLRL-EVKLGQGCFGEVWMGTWNGTTR---VAIKTLKPGTM--SPEAFLQEAQVMK 318 + R++L + +++LG G FG V G + + VAIK LK GT E ++EAQ+M Sbjct: 6 LKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGTEKADTEEMMREAQIMH 65 Query: 319 KLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378 +L + +V+L V E + +V E G L FL G+ + + + + ++ Q++ GM Sbjct: 66 QLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFLVGKREE-IPVSNVAELLHQVSMGMK 124 Query: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEA 436 Y+E N+VHRDL A N+L+ K++DFGL++ + +D+ YTAR K+P+KW APE Sbjct: 125 YLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPEC 184 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 + +F+ +SDVWS+G+ + E + G+ PY M EV+ +E+G RM CPPECP L+ Sbjct: 185 INFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYA 244 Query: 497 LMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQP 532 LM CW + E+RP F ++ + + S + + Sbjct: 245 LMSDCWIYKWEDRPDFLTVEQRMRACYYSLASKVEG 280 >5KMM-A nrPDB Length = 329 Score = 284 bits (726), Expect = 7e-77, Method: Composition-based stats. Identities = 97/281 (34%), Positives = 160/281 (56%), Gaps = 22/281 (7%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWN------GTTRVAIKTLKPGTMS-PEAFLQEAQV 316 I R + L+ +LG+G FG+V++ + VA+K LK + S + F +EA++ Sbjct: 31 HIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAEL 90 Query: 317 MKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGE-------------TGKYLR 362 + L+H+ +V+ + V +E P+ +V EYM G L FL+ L Sbjct: 91 LTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLG 150 Query: 363 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTAR 422 L QL+ +A+Q+A+GM Y+ +++VHRDL N LVG+ LV K+ DFG++R I +Y Sbjct: 151 LGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRV 210 Query: 423 QG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481 G PI+W PE+ LY +FT +SDVWSFG++L E+ T G+ P+ + N E +D + +G Sbjct: 211 GGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQG 270 Query: 482 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 + P CP ++ +M CW++EP++R + + + A L+ Sbjct: 271 RELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQAL 311 >3ZBF-A nrPDB Length = 322 Score = 283 bits (724), Expect = 1e-76, Method: Composition-based stats. Identities = 120/286 (41%), Positives = 165/286 (57%), Gaps = 21/286 (7%) Query: 256 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTW-------NGTTRVAIKTLKPGTMSPE 308 QG ++ PRE L L + LG G FGEV+ GT +G +VA+KTLK G+ E Sbjct: 21 QGSIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQE 80 Query: 309 --AFLQEAQVMKKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGET-----GKY 360 FL+EA +M K H +++ V EP YI+ E M G LL +L+ G Sbjct: 81 KIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPL 140 Query: 361 LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-----ENLVCKVADFGLARLIE 415 L L LVD+ I+ G Y+ERM+++HRDL A N LV + K+ DFGLAR I Sbjct: 141 LTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIY 200 Query: 416 DNEYTARQGAKF-PIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREV 474 N+Y ++G P++W APE+ + G FT +SDVWSFGIL+ E+ T G PYP N +V Sbjct: 201 KNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDV 260 Query: 475 LDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 L+ V+ G R+ P CP+ L +LM QCW +EP++RPTF +Q L+ Sbjct: 261 LNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQ 306 >3G0E-A nrPDB Length = 336 Score = 283 bits (724), Expect = 1e-76, Method: Composition-based stats. Identities = 101/302 (33%), Positives = 150/302 (49%), Gaps = 28/302 (9%) Query: 251 SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR------VAIKTLKPGT 304 TQ WE PR L LG G FG+V T G + VA+K LKP Sbjct: 29 YIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSA 88 Query: 305 M--SPEAFLQEAQVMKKL-RHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKY 360 EA + E +V+ L H +V L + P ++TEY G LL+FL+ + + Sbjct: 89 HLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSF 148 Query: 361 LRLPQ----------------LVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCK 404 + L+ + Q+A GMA++ N +HRDL A NIL+ + K Sbjct: 149 ICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITK 208 Query: 405 VADFGLARLIEDNE-YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGR 463 + DFGLAR I+++ Y + A+ P+KW APE+ +T +SDVWS+GI L EL + G Sbjct: 209 ICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGS 268 Query: 464 VPYPGMV-NREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 PYPGM + + ++ G+RM P P ++D+M CW +P +RPTF+ + +E Sbjct: 269 SPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQ 328 Query: 523 FT 524 + Sbjct: 329 IS 330 >6BSD-A nrPDB Length = 876 Score = 280 bits (717), Expect = 1e-75, Method: Composition-based stats. Identities = 108/321 (33%), Positives = 159/321 (49%), Gaps = 46/321 (14%) Query: 245 TTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR---------- 294 T P P G + PR LR + KLG+G FGEV + + Sbjct: 548 TYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNV 607 Query: 295 -------VAIKTLKPGTMS--PEAFLQEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYM 344 VA+K L+P FL+E ++M +L+ +++L V ++P+ ++T+YM Sbjct: 608 RKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYM 667 Query: 345 SKGSLLDFLKGET-----------------GKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 G L FL G + P L+ +AAQIASGM Y+ +N+VH Sbjct: 668 ENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVH 727 Query: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG-AKFPIKWTAPEAALYGRFTIKS 446 RDL N LVGEN K+ADFG++R + +Y QG A PI+W A E L G+FT S Sbjct: 728 RDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTAS 787 Query: 447 DVWSFGILLTELTTKGRV-PYPGMVNREVLDQVERGYR-------MPCPPECPESLHDLM 498 DVW+FG+ L E+ R P+ + + +V++ +R + PP CP+ L++LM Sbjct: 788 DVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELM 847 Query: 499 CQCWRKEPEERPTFEYLQAFL 519 +CW +E E+RP F L FL Sbjct: 848 LRCWSRESEQRPPFSQLHRFL 868 >5FM2-A nrPDB Length = 355 Score = 280 bits (716), Expect = 1e-75, Method: Composition-based stats. Identities = 110/322 (34%), Positives = 160/322 (49%), Gaps = 32/322 (9%) Query: 233 YSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGT---W 289 YS + S + L WE PR++L L LG+G FG+V T Sbjct: 29 YSSSGARRPSLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL 88 Query: 290 NGT---TRVAIKTLKPGTMSPE--AFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEY 343 G T VA+K LK E L E V+K++ H +++LY S++ P+ ++ EY Sbjct: 89 KGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEY 148 Query: 344 MSKGSLLDFLKGETG----------------------KYLRLPQLVDMAAQIASGMAYVE 381 GSL FL+ + L + L+ A QI+ GM Y+ Sbjct: 149 AKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLA 208 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLI-EDNEYTARQGAKFPIKWTAPEAALYG 440 M VHRDL A NILV E K++DFGL+R + E++ Y R + P+KW A E+ Sbjct: 209 EMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDH 268 Query: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQ 500 +T +SDVWSFG+LL E+ T G PYPG+ + + ++ G+RM P C E ++ LM Q Sbjct: 269 IYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQ 328 Query: 501 CWRKEPEERPTFEYLQAFLEDY 522 CW++EP++RP F + LE Sbjct: 329 CWKQEPDKRPVFADISKDLEKM 350 >3I81-A nrPDB Length = 315 Score = 280 bits (716), Expect = 1e-75, Method: Composition-based stats. Identities = 106/292 (36%), Positives = 157/292 (53%), Gaps = 25/292 (8%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNG------TTRVAIKTLKPGTMSPEA--FL 311 D WE+ RE + + +LGQG FG V+ G G TRVAIKT+ E FL Sbjct: 10 PDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFL 69 Query: 312 QEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGK--------YLR 362 EA VMK+ +V+L VVS+ +P ++ E M++G L +L+ + Sbjct: 70 NEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPS 129 Query: 363 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTAR 422 L +++ MA +IA GMAY+ +VHRDL A N +V E+ K+ DFG+ R I + +Y + Sbjct: 130 LSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRK 189 Query: 423 QGAKF-PIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481 G P++W +PE+ G FT SDVWSFG++L E+ T PY G+ N +VL V G Sbjct: 190 GGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEG 249 Query: 482 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPG 533 + P CP+ L +LM CW+ P+ RP+F + +S + + +PG Sbjct: 250 GLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI-------ISSIKEEMEPG 294 >5X02-A nrPDB Length = 347 Score = 279 bits (715), Expect = 1e-75, Method: Composition-based stats. Identities = 105/302 (34%), Positives = 155/302 (51%), Gaps = 33/302 (10%) Query: 251 SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNG------TTRVAIKTLKP-- 302 + WE PRE+L LG G FG+V T G + +VA+K LK Sbjct: 31 YVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKA 90 Query: 303 GTMSPEAFLQEAQVMKKL-RHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKY 360 + EA + E ++M +L HE +V L + PIY++ EY G LL++L+ + K+ Sbjct: 91 DSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKF 150 Query: 361 ---------------------LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE 399 L L+ A Q+A GM ++E + VHRDL A N+LV Sbjct: 151 SEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTH 210 Query: 400 NLVCKVADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTEL 458 V K+ DFGLAR ++ D+ Y R A+ P+KW APE+ G +TIKSDVWS+GILL E+ Sbjct: 211 GKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEI 270 Query: 459 TTKGRVPYPGMV-NREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQA 517 + G PYPG+ + ++ G++M P E ++ +M CW + +RP+F L + Sbjct: 271 FSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTS 330 Query: 518 FL 519 FL Sbjct: 331 FL 332 >3BBT-B nrPDB Length = 328 Score = 279 bits (715), Expect = 1e-75, Method: Composition-based stats. Identities = 102/273 (37%), Positives = 140/273 (51%), Gaps = 11/273 (4%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNGTTR-----VAIKTLKPGTMSPE--AFLQEAQVM 317 + L+ LG G FG V+ G W VAIK L T F+ EA +M Sbjct: 12 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIM 71 Query: 318 KKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 + H LV+L V I +VT+ M G LL+++ L++ QIA GM Sbjct: 72 ASMDHPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGS-QLLLNWCVQIAKGM 130 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEY-TARQGAKFPIKWTAPEA 436 Y+E VHRDL A N+LV K+ DFGLARL+E +E G K PIKW A E Sbjct: 131 MYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALEC 190 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 Y +FT +SDVWS+G+ + EL T G PY G+ RE+ D +E+G R+P PP C ++ Sbjct: 191 IHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYM 250 Query: 497 LMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 +M +CW + + RP F+ L A + +PQ Sbjct: 251 VMVKCWMIDADSRPKFKELAAEFSRM--ARDPQ 281 >1FVR-A nrPDB Length = 327 Score = 279 bits (715), Expect = 2e-75, Method: Composition-based stats. Identities = 95/301 (31%), Positives = 144/301 (47%), Gaps = 23/301 (7%) Query: 244 LTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT---RVAIKTL 300 + + + ++ + +G+G FG+V AIK + Sbjct: 1 MKKHHHHHHGKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRM 60 Query: 301 KP--GTMSPEAFLQEAQVMKKL-RHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLK-- 354 K F E +V+ KL H ++ L +Y+ EY G+LLDFL+ Sbjct: 61 KEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKS 120 Query: 355 ------------GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLV 402 T L QL+ AA +A GM Y+ + ++HRDL A NILVGEN V Sbjct: 121 RVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYV 180 Query: 403 CKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKG 462 K+ADFGL+R Y + + P++W A E+ Y +T SDVWS+G+LL E+ + G Sbjct: 181 AKIADFGLSR--GQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLG 238 Query: 463 RVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 PY GM E+ +++ +GYR+ P C + ++DLM QCWR++P ERP+F + L Sbjct: 239 GTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRM 298 Query: 523 F 523 Sbjct: 299 L 299 >5HLW-A nrPDB Length = 299 Score = 279 bits (715), Expect = 2e-75, Method: Composition-based stats. Identities = 97/273 (35%), Positives = 145/273 (53%), Gaps = 12/273 (4%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTT----RVAIKTLKPGTMSPE--AFLQEAQVMKKLRHE 323 + +G+G FG V+ GT A+K+L T E FL E +MK H Sbjct: 22 VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP 81 Query: 324 KLVQLYAVV--SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 ++ L + SE +V YM G L +F++ ET + L+ Q+A GM Y+ Sbjct: 82 NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKYLA 140 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA---RQGAKFPIKWTAPEAAL 438 +VHRDL A N ++ E KVADFGLAR + D EY + + GAK P+KW A E+ Sbjct: 141 SKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALESLQ 200 Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM 498 +FT KSDVWSFG+LL EL T+G PYP + ++ + +G R+ P CP+ L+++M Sbjct: 201 TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM 260 Query: 499 CQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQ 531 +CW + E RP+F L + + F++ ++ Sbjct: 261 LKCWHPKAEMRPSFSELVSRISAIFSTFIGEHY 293 >4XUF-A nrPDB Length = 297 Score = 279 bits (715), Expect = 2e-75, Method: Composition-based stats. Identities = 105/291 (36%), Positives = 154/291 (52%), Gaps = 33/291 (11%) Query: 262 AWEIPRESLRLEVKLGQGCFGEVWMGTWNG------TTRVAIKTLKP--GTMSPEAFLQE 313 WE PRE+L LG G FG+V T G + +VA+K LK + EA + E Sbjct: 3 KWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSE 62 Query: 314 AQVMKKL-RHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKY----------- 360 ++M +L HE +V L + PIY++ EY G LL++L+ + K+ Sbjct: 63 LKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQK 122 Query: 361 ----------LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGL 410 L L+ A Q+A GM ++E + VHRDL A N+LV V K+ DFGL Sbjct: 123 RLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGL 182 Query: 411 AR-LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM 469 AR ++ D+ Y R A+ P+KW APE+ G +TIKSDVWS+GILL E+ + G PYPG+ Sbjct: 183 ARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGI 242 Query: 470 V-NREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFL 519 + ++ G++M P E ++ +M CW + +RP+F L +FL Sbjct: 243 PVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 293 >5GRN-A nrPDB Length = 356 Score = 279 bits (713), Expect = 3e-75, Method: Composition-based stats. Identities = 104/309 (33%), Positives = 155/309 (50%), Gaps = 36/309 (11%) Query: 251 SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNG------TTRVAIKTLKPGT 304 Q WE PR+ L L LG G FG+V GT G +VA+K LKP Sbjct: 29 YVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTA 88 Query: 305 MS--PEAFLQEAQVMKKLR-HEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKY 360 S +A + E ++M L H +V L ++ PIYI+TEY G L+++L + Sbjct: 89 RSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSF 148 Query: 361 LRLP------------------------QLVDMAAQIASGMAYVERMNYVHRDLRAANIL 396 L L+ Q+A GM ++ N VHRDL A N+L Sbjct: 149 LSHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVL 208 Query: 397 VGENLVCKVADFGLAR-LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILL 455 + + + K+ DFGLAR ++ D+ Y ++ P+KW APE+ +T SDVWS+GILL Sbjct: 209 LAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILL 268 Query: 456 TELTTKGRVPYPG-MVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEY 514 E+ + G PYPG MV+ ++++ GYRM P ++++M +CW EPE+RP+F + Sbjct: 269 WEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYH 328 Query: 515 LQAFLEDYF 523 L +E+ Sbjct: 329 LSEIVENLL 337 >3CJF-A nrPDB Length = 309 Score = 279 bits (713), Expect = 3e-75, Method: Composition-based stats. Identities = 97/292 (33%), Positives = 147/292 (50%), Gaps = 23/292 (7%) Query: 257 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR------VAIKTLKPGTMSPE-- 308 WE PR+ L L LG+G FG+V G + VA+K LK G E Sbjct: 16 PYDASKWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHR 75 Query: 309 AFLQEAQVMKKLRHE-KLVQLYAVVSE--EPIYIVTEYMSKGSLLDFLKGETGKY----- 360 A + E +++ + H +V L ++ P+ ++ E+ G+L +L+ + ++ Sbjct: 76 ALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKD 135 Query: 361 -----LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE 415 L L L+ + Q+A GM ++ +HRDL A NIL+ E V K+ DFGLAR I Sbjct: 136 LYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIY 195 Query: 416 -DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMV-NRE 473 D +Y + A+ P+KW APE +TI+SDVWSFG+LL E+ + G PYPG+ + E Sbjct: 196 KDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEE 255 Query: 474 VLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTS 525 +++ G RM P ++ M CW EP +RPTF L L + + Sbjct: 256 FCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQA 307 >1LUF-A nrPDB Length = 343 Score = 278 bits (712), Expect = 4e-75, Method: Composition-based stats. Identities = 101/313 (32%), Positives = 154/313 (49%), Gaps = 32/313 (10%) Query: 247 VCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT------TRVAIKTL 300 P + E PR ++ +G+G FG V+ G T VA+K L Sbjct: 26 PMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKML 85 Query: 301 KPGTMS--PEAFLQEAQVMKKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGET 357 K + F +EA +M + + +V+L V + +P+ ++ EYM+ G L +FL+ + Sbjct: 86 KEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMS 145 Query: 358 G----------------------KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANI 395 L + + +A Q+A+GMAY+ +VHRDL N Sbjct: 146 PHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNC 205 Query: 396 LVGENLVCKVADFGLARLIEDNEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGIL 454 LVGEN+V K+ADFGL+R I +Y G PI+W PE+ Y R+T +SDVW++G++ Sbjct: 206 LVGENMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVV 265 Query: 455 LTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEY 514 L E+ + G PY GM + EV+ V G + CP CP L++LM CW K P +RP+F Sbjct: 266 LWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCS 325 Query: 515 LQAFLEDYFTSTE 527 + L+ E Sbjct: 326 IHRILQRMCERAE 338 >3QUP-A nrPDB Length = 323 Score = 278 bits (711), Expect = 5e-75, Method: Composition-based stats. Identities = 103/292 (35%), Positives = 149/292 (51%), Gaps = 26/292 (8%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNGTT----RVAIKTLKPG---TMSPEAFLQEAQVM 317 IP + L LG+G FG V +VA+K LK + E FL+EA M Sbjct: 20 IPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACM 79 Query: 318 KKLRHEKLVQLYAVVSEEPI-------YIVTEYMSKGSLLDFLK----GETGKYLRLPQL 366 K+ H + +L V ++ +M G L FL GE L L L Sbjct: 80 KEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTL 139 Query: 367 VDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGA- 425 V IA GM Y+ N++HRDL A N ++ E++ VADFGL+R I +Y + A Sbjct: 140 VRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCAS 199 Query: 426 KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP 485 K P+KW A E+ +T+ SDVW+FG+ + E+ T+G+ PY G+ N E+ + + G R+ Sbjct: 200 KLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLK 259 Query: 486 CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF-------TSTEPQY 530 PPEC E ++DLM QCW +P++RP+F L+ LE+ TS +P Y Sbjct: 260 QPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGHLSVLSTSQDPLY 311 >6FEX-A nrPDB Length = 321 Score = 278 bits (710), Expect = 6e-75, Method: Composition-based stats. Identities = 105/307 (34%), Positives = 156/307 (50%), Gaps = 40/307 (13%) Query: 253 PQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-----------------V 295 P G + PR LR + KLG+G FGEV + + V Sbjct: 1 PGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLV 60 Query: 296 AIKTLKPGTMS--PEAFLQEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDF 352 A+K L+P FL+E ++M +L+ +++L V ++P+ ++T+YM G L F Sbjct: 61 AVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQF 120 Query: 353 LKGET-----------GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENL 401 L + P L+ +AAQIASGM Y+ +N+VHRDL N LVGEN Sbjct: 121 LSAHQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENF 180 Query: 402 VCKVADFGLARLIEDNEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTT 460 K+ADFG++R + +Y QG A PI+W A E L G+FT SDVW+FG+ L E+ Sbjct: 181 TIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLM 240 Query: 461 KGRV-PYPGMVNREVLDQVERGYR-------MPCPPECPESLHDLMCQCWRKEPEERPTF 512 R P+ + + +V++ +R + PP CP+ L++LM +CW +E E+RP F Sbjct: 241 LCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPF 300 Query: 513 EYLQAFL 519 L FL Sbjct: 301 SQLHRFL 307 >3PPZ-A nrPDB Length = 309 Score = 278 bits (710), Expect = 6e-75, Method: Composition-based stats. Identities = 92/280 (32%), Positives = 142/280 (50%), Gaps = 11/280 (3%) Query: 257 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA---FLQE 313 + D +IP L ++ K+G G FG V W+G+ VA+K L E FL+E Sbjct: 26 AMDGDDMDIPWCDLNIKEKIGAGSFGTVHRAEWHGSD-VAVKILMEQDFHAERVNEFLRE 84 Query: 314 AQVMKKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGE-TGKYLRLPQLVDMAA 371 +MK+LRH +V V++ P + IVTEY+S+GSL L + L + + MA Sbjct: 85 VAIMKRLRHPNIVLFMGAVTQPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAY 144 Query: 372 QIASGMAYVERMN--YVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 429 +A GM Y+ N VHRDL++ N+LV + KV DFGL+R ++ + + + + A Sbjct: 145 DVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSR-LKASTFLSSKSAAGTP 203 Query: 430 KWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRMPCPP 488 +W APE KSDV+SFG++L EL T + P+ + +V+ V + R+ P Sbjct: 204 EWMAPEVLRDEPSNEKSDVYSFGVILWELATL-QQPWGNLNPAQVVAAVGFKCKRLEIPR 262 Query: 489 ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEP 528 + ++ CW EP +RP+F + L S P Sbjct: 263 NLNPQVAAIIEGCWTNEPWKRPSFATIMDLLRPLIKSAVP 302 >3C1X-A nrPDB Length = 373 Score = 275 bits (703), Expect = 3e-74, Method: Composition-based stats. Identities = 95/273 (34%), Positives = 145/273 (53%), Gaps = 12/273 (4%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTT----RVAIKTLKPGTMSPE--AFLQEAQVMKKLRHE 323 + +G+G FG V+ GT A+K+L T E FL E +MK H Sbjct: 91 VHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP 150 Query: 324 KLVQLYAVV--SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 ++ L + SE +V YM G L +F++ ET + L+ Q+A GM ++ Sbjct: 151 NVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVAKGMKFLA 209 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA---RQGAKFPIKWTAPEAAL 438 +VHRDL A N ++ E KVADFGLAR + D E+ + + GAK P+KW A E+ Sbjct: 210 SKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALESLQ 269 Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM 498 +FT KSDVWSFG+LL EL T+G PYP + ++ + +G R+ P CP+ L+++M Sbjct: 270 TQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVM 329 Query: 499 CQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQ 531 +CW + E RP+F L + + F++ ++ Sbjct: 330 LKCWHPKAEMRPSFSELVSRISAIFSTFIGEHY 362 >5U6C-A nrPDB Length = 315 Score = 271 bits (694), Expect = 4e-73, Method: Composition-based stats. Identities = 97/280 (34%), Positives = 144/280 (51%), Gaps = 18/280 (6%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNGTT----RVAIKTLKPG---TMSPEAFLQEAQVM 317 I R L L LG+G FG V G +VA+KT+K E FL EA M Sbjct: 33 IDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACM 92 Query: 318 KKLRHEKLVQLYAVVSE------EPIYIVTEYMSKGSLLDFLKGET----GKYLRLPQLV 367 K H +++L V E ++ +M G L +L K++ L L+ Sbjct: 93 KDFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLL 152 Query: 368 DMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG-AK 426 IA GM Y+ N++HRDL A N ++ +++ VADFGL++ I +Y + AK Sbjct: 153 KFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAK 212 Query: 427 FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPC 486 P+KW A E+ +T KSDVW+FG+ + E+ T+G PYPG+ N E+ D + G+R+ Sbjct: 213 MPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQ 272 Query: 487 PPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 P +C + L+++M CWR +P +RPTF L+ LE S Sbjct: 273 PEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESL 312 >6FER-A nrPDB Length = 309 Score = 271 bits (693), Expect = 6e-73, Method: Composition-based stats. Identities = 100/293 (34%), Positives = 154/293 (52%), Gaps = 37/293 (12%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-----------------VAIKTLKPG--T 304 E PR+ L + KLG+G FGEV + G + VA+K L+ Sbjct: 5 EFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANK 64 Query: 305 MSPEAFLQEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETG----- 358 + FL+E ++M +L+ ++ L AV +++P+ ++TEYM G L FL Sbjct: 65 NARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSS 124 Query: 359 ---KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE 415 + + L MA QIASGM Y+ +N+VHRDL N LVG+N K+ADFG++R + Sbjct: 125 SDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLY 184 Query: 416 DNEYTARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKG-RVPYPGMVNRE 473 +Y QG A PI+W + E+ L G+FT SDVW+FG+ L E T PY + + + Sbjct: 185 SGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQ 244 Query: 474 VLDQVERGYR-------MPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFL 519 V++ +R +P P CP+S++ LM CWR++ + RP+F+ + L Sbjct: 245 VIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLL 297 >4GS6-A nrPDB Length = 315 Score = 270 bits (691), Expect = 8e-73, Method: Composition-based stats. Identities = 82/282 (29%), Positives = 130/282 (46%), Gaps = 19/282 (6%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324 I + + +E +G+G FG V W VAIK + +AF+ E + + ++ H Sbjct: 6 IDYKEIEVEEVVGRGAFGVVCKAKWRAKD-VAIKQI-ESESERKAFIVELRQLSRVNHPN 63 Query: 325 LVQLYAVVSEEPIYIVTEYMSKGSLLDFLKG-ETGKYLRLPQLVDMAAQIASGMAYVERM 383 +V+LY P+ +V EY GSL + L G E Y + Q + G+AY+ M Sbjct: 64 IVKLYGACL-NPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSM 122 Query: 384 N---YVHRDLRAANILVGENLVC-KVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 +HRDL+ N+L+ K+ DFG A I+ T K W APE Sbjct: 123 QPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ----THMTNNKGSAAWMAPEVFEG 178 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYP--GMVNREVLDQVERGYRMPCPPECPESLHDL 497 ++ K DV+S+GI+L E+ T+ R P+ G ++ V G R P P+ + L Sbjct: 179 SNYSEKCDVFSWGIILWEVITR-RKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESL 237 Query: 498 MCQCWRKEPEERPTFEYLQAFLEDYFT----STEPQYQPGEN 535 M +CW K+P +RP+ E + + + EP P ++ Sbjct: 238 MTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQH 279 >4FL3-A nrPDB Length = 635 Score = 270 bits (691), Expect = 1e-72, Method: Composition-based stats. Identities = 116/470 (24%), Positives = 195/470 (41%), Gaps = 94/470 (20%) Query: 147 QAEEWYFGKITRRESERL-----------LLNAENPRGTFLV-----------RESETTK 184 + W+ GKI+R ESE++ L+ A + G++ + R + Sbjct: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKT 223 Query: 185 GAYCLSVSDFDNAKGLNVKHY--------KIRKLDSGGFYITSRTQFNSLQQLVAYY--S 234 G + + V+HY ++ + F QL + + Sbjct: 224 GKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPAT 283 Query: 235 KHADGLCHRL-------------------------------------------------- 244 A G+ R+ Sbjct: 284 WSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPM 343 Query: 245 -TTVCPTSKPQTQGLAKDAWEIPRESLRLE-VKLGQGCFGEVWMGTWN------GTTRVA 296 T V + + + + R+ L LE +LG G FG V G + Sbjct: 344 DTEVFESPFADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKI 403 Query: 297 IKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGE 356 +K + L EA VM++L + +V++ + E +V E G L +L + Sbjct: 404 LKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYL--Q 461 Query: 357 TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI-- 414 ++++ ++++ Q++ GM Y+E N+VHRDL A N+L+ K++DFGL++ + Sbjct: 462 QNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA 521 Query: 415 EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREV 474 ++N Y A+ K+P+KW APE Y +F+ KSDVWSFG+L+ E + G+ PY GM EV Sbjct: 522 DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 581 Query: 475 LDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFT 524 +E+G RM CP CP ++DLM CW + E RP F ++ L +Y+ Sbjct: 582 TAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYY 631 Score = 82.3 bits (202), Expect = 5e-16, Method: Composition-based stats. Identities = 37/132 (28%), Positives = 57/132 (43%), Gaps = 8/132 (6%) Query: 143 SDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV 202 +DS ++FG ITR E+E L+ G +L+R+S G + LSV A G Sbjct: 7 ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSV-----AHGRKA 61 Query: 203 KHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC---PTSKPQTQGLA 259 HY I + +G + I S L Y+S+ +DGL L +P+T Sbjct: 62 HHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFE 121 Query: 260 KDAWEIPRESLR 271 + RE ++ Sbjct: 122 DLKENLIREYVK 133 >3PP0-A nrPDB Length = 338 Score = 270 bits (690), Expect = 1e-72, Method: Composition-based stats. Identities = 102/273 (37%), Positives = 143/273 (52%), Gaps = 11/273 (4%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNGTTR-----VAIKTLKPGTMSP--EAFLQEAQVM 317 + LR LG G FG V+ G W VAIK L+ T + L EA VM Sbjct: 14 LKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVM 73 Query: 318 KKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 + + +L + + +VT+ M G LLD ++ G+ L L++ QIA GM Sbjct: 74 AGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGR-LGSQDLLNWCMQIAKGM 132 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEA 436 +Y+E + VHRDL A N+LV K+ DFGLARL++ D G K PIKW A E+ Sbjct: 133 SYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALES 192 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 L RFT +SDVWS+G+ + EL T G PY G+ RE+ D +E+G R+P PP C ++ Sbjct: 193 ILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYM 252 Query: 497 LMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 +M +CW + E RP F L + + +PQ Sbjct: 253 IMVKCWMIDSECRPRFRELVSEFSRM--ARDPQ 283 >3PLS-A nrPDB Length = 298 Score = 269 bits (688), Expect = 2e-72, Method: Composition-based stats. Identities = 99/265 (37%), Positives = 145/265 (54%), Gaps = 12/265 (4%) Query: 273 EVKLGQGCFGEVWMGTW----NGTTRVAIKTLKPGT--MSPEAFLQEAQVMKKLRHEKLV 326 + +G+G FG V+ G + + AIK+L T EAFL+E +M+ L H ++ Sbjct: 26 DRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVL 85 Query: 327 QLYAVVSEEP--IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN 384 L ++ +++ YM G LL F++ + L+ Q+A GM Y+ Sbjct: 86 ALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNP-TVKDLISFGLQVARGMEYLAEQK 144 Query: 385 YVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ---GAKFPIKWTAPEAALYGR 441 +VHRDL A N ++ E+ KVADFGLAR I D EY + Q A+ P+KWTA E+ R Sbjct: 145 FVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALESLQTYR 204 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 501 FT KSDVWSFG+LL EL T+G PY + ++ + +G R+P P CP+SL+ +M QC Sbjct: 205 FTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQC 264 Query: 502 WRKEPEERPTFEYLQAFLEDYFTST 526 W +P RPTF L +E ++ Sbjct: 265 WEADPAVRPTFRVLVGEVEQIVSAL 289 >5GNK-A nrPDB Length = 297 Score = 266 bits (680), Expect = 2e-71, Method: Composition-based stats. Identities = 89/273 (32%), Positives = 136/273 (49%), Gaps = 11/273 (4%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTW-----NGTTRVAIKTLKPGTMSP--EAFLQEAQVM 317 + + LG G FG V+ G W VAIK L+ T + L EA VM Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 75 Query: 318 KKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 + + + +L + + ++ + M G LLD+++ L++ QIA GM Sbjct: 76 ASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGS-QYLLNWCVQIAKGM 134 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI-EDNEYTARQGAKFPIKWTAPEA 436 Y+E VHRDL A N+LV K+ DFGLA+L+ + + +G K PIKW A E+ Sbjct: 135 NYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALES 194 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 L+ +T +SDVWS+G+ + EL T G PY G+ E+ +E+G R+P PP C ++ Sbjct: 195 ILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYM 254 Query: 497 LMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 +M +CW + + RP F L + +PQ Sbjct: 255 IMVKCWMIDADSRPKFRELIIEFSKM--ARDPQ 285 >3LZB-A nrPDB Length = 327 Score = 266 bits (679), Expect = 2e-71, Method: Composition-based stats. Identities = 90/273 (32%), Positives = 137/273 (50%), Gaps = 11/273 (4%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTW-----NGTTRVAIKTLKPGTMSP--EAFLQEAQVM 317 + + LG G FG V+ G W VAIK L+ T + L EA VM Sbjct: 12 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 71 Query: 318 KKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 + + + +L + + ++T+ M G LLD+++ L++ QIA GM Sbjct: 72 ASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGS-QYLLNWCVQIAKGM 130 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI-EDNEYTARQGAKFPIKWTAPEA 436 Y+E VHRDL A N+LV K+ DFGLA+L+ + + +G K PIKW A E+ Sbjct: 131 NYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALES 190 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 L+ +T +SDVWS+G+ + EL T G PY G+ E+ +E+G R+P PP C ++ Sbjct: 191 ILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYM 250 Query: 497 LMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 +M +CW + + RP F L + +PQ Sbjct: 251 IMRKCWMIDADSRPKFRELIIEFSKM--ARDPQ 281 >5X5O-A nrPDB Length = 310 Score = 264 bits (675), Expect = 6e-71, Method: Composition-based stats. Identities = 80/275 (29%), Positives = 134/275 (48%), Gaps = 17/275 (6%) Query: 254 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQ 312 G +I + L+ G G FG V+ W + VA+K L + Sbjct: 1 GAMGSGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK-------IEK 53 Query: 313 EAQVMKKLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA 371 EA+++ L H ++Q Y V+ E P Y IVTEY S GSL D++ + + + ++ A Sbjct: 54 EAEILSVLSHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWAT 113 Query: 372 QIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFP 428 +A GM Y+ +HRDL++ N+++ + V K+ DFG +R + +T Sbjct: 114 DVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF---HNHTTHMSLVGT 170 Query: 429 IKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCP 487 W APE + D +S+G++L E+ T+ VP+ G+ +V V E+ R+ P Sbjct: 171 FPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTR-EVPFKGLEGLQVAWLVVEKNERLTIP 229 Query: 488 PECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 CP S +L+ QCW + ++RP+F+ + + LE Sbjct: 230 SSCPRSFAELLHQCWEADAKKRPSFKQIISILESM 264 >6DBN-A nrPDB Length = 316 Score = 263 bits (673), Expect = 1e-70, Method: Composition-based stats. Identities = 93/290 (32%), Positives = 144/290 (49%), Gaps = 27/290 (9%) Query: 261 DAWEIPRESLRLEVKLGQGCFGEVWMGT-----WNGTTRVAIKTLKPGT--MSPEAFLQE 313 D + L+ LG+G FG+V + N +VA+K+LKP + +E Sbjct: 28 DPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKE 87 Query: 314 AQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMA 370 ++++ L HE +V+ + +E+ I ++ E++ GSL ++L K + L Q + A Sbjct: 88 IEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNK-INLKQQLKYA 146 Query: 371 AQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE--YTARQGAKFP 428 QI GM Y+ YVHRDL A N+LV K+ DFGL + IE ++ YT + P Sbjct: 147 VQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSP 206 Query: 429 IKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRV-------------PYPG-MVNREV 474 + W APE + +F I SDVWSFG+ L EL T P G M + Sbjct: 207 VFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRL 266 Query: 475 LDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFT 524 ++ ++ G R+PCPP CP+ ++ LM +CW +P R +F+ L E Sbjct: 267 VNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK 316 >3ZZW-A nrPDB Length = 289 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 99/284 (34%), Positives = 154/284 (54%), Gaps = 24/284 (8%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNG------TTRVAIKTLKPGTMSP--EAFLQEA 314 EI ++R +LG+ FG+V+ G G T VAIKTLK P E F EA Sbjct: 4 KEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEA 63 Query: 315 QVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGK-------------- 359 + +L+H +V L VV+++ P+ ++ Y S G L +FL + Sbjct: 64 MLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKS 123 Query: 360 YLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEY 419 L P V + AQIA+GM Y+ + VH+DL N+LV + L K++D GL R + +Y Sbjct: 124 ALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADY 183 Query: 420 TARQG-AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 G + PI+W APEA +YG+F+I SD+WS+G++L E+ + G PY G N++V++ + Sbjct: 184 YKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMI 243 Query: 479 ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 +PCP +CP ++ LM +CW + P RP F+ + + L + Sbjct: 244 RNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAW 287 >3AOX-A nrPDB Length = 344 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 106/307 (34%), Positives = 157/307 (51%), Gaps = 19/307 (6%) Query: 233 YSKHADGLCHRLTTVCPTSKPQTQGLA-KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNG 291 Y +T P + + D E+PR+++ L LG G FGEV+ G +G Sbjct: 11 YKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSG 70 Query: 292 ------TTRVAIKTLKP--GTMSPEAFLQEAQVMKKLRHEKLVQLYAV-VSEEPIYIVTE 342 +VA+KTL FL EA ++ K H+ +V+ V + P +I+ E Sbjct: 71 MPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQSLPRFILLE 130 Query: 343 YMSKGSLLDFLKGETGKY-----LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILV 397 M+ G L FL+ + L + L+ +A IA G Y+E +++HRD+ A N L+ Sbjct: 131 LMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLL 190 Query: 398 ---GENLVCKVADFGLARLIEDNEYTARQGA-KFPIKWTAPEAALYGRFTIKSDVWSFGI 453 G V K+ DFG+AR I Y + G P+KW PEA + G FT K+D WSFG+ Sbjct: 191 TCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGV 250 Query: 454 LLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFE 513 LL E+ + G +PYP N+EVL+ V G RM P CP ++ +M QCW+ +PE+RP F Sbjct: 251 LLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFA 310 Query: 514 YLQAFLE 520 + +E Sbjct: 311 IILERIE 317 >5C26-A nrPDB Length = 299 Score = 263 bits (671), Expect = 2e-70, Method: Composition-based stats. Identities = 94/289 (32%), Positives = 152/289 (52%), Gaps = 11/289 (3%) Query: 245 TTVCPTSKPQTQGLAKDAWEIPRESLRLE-VKLGQGCFGEVWMGTWN------GTTRVAI 297 T V + + + + R+ L LE +LG G FG V G + + Sbjct: 3 TEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKIL 62 Query: 298 KTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGET 357 K + L EA VM++L + +V++ + E +V E G L +L + Sbjct: 63 KNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYL--QQ 120 Query: 358 GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--E 415 ++++ ++++ Q++ GM Y+E N+VHRDL A N+L+ K++DFGL++ + + Sbjct: 121 NRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD 180 Query: 416 DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVL 475 +N Y A+ K+P+KW APE Y +F+ KSDVWSFG+L+ E + G+ PY GM EV Sbjct: 181 ENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVT 240 Query: 476 DQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFT 524 +E+G RM CP CP ++DLM CW + E RP F ++ L +Y+ Sbjct: 241 AMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYY 289 >6DBM-A nrPDB Length = 318 Score = 263 bits (671), Expect = 2e-70, Method: Composition-based stats. Identities = 94/300 (31%), Positives = 141/300 (47%), Gaps = 33/300 (11%) Query: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-----TRVAIKTLKPGT--MSPEAFL 311 D + L+ LG+G FG+V + ++ T VA+K LK + Sbjct: 22 PGDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWK 81 Query: 312 QEAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD 368 QE +++ L HE +++ + + +V EY+ GSL D+L + + L QL+ Sbjct: 82 QEIDILRTLYHEHIIKYKGCCEDAGAASLQLVMEYVPLGSLRDYLPRHS---IGLAQLLL 138 Query: 369 MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE--YTARQGAK 426 A QI GMAY+ +Y+HRDL A N+L+ + + K+ DFGLA+ + + Y R+ Sbjct: 139 FAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGD 198 Query: 427 FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKG----RVPYP----------GMVNR 472 P+ W APE +F SDVWSFG+ L EL T P M Sbjct: 199 SPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVL 258 Query: 473 EVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQP 532 + + +ERG R+P P +CP ++ LM CW E RPTFE L L + +YQ Sbjct: 259 RLTELLERGERLPRPDKCPAEVYHLMKNCWETEASFRPTFENLIPIL----KTVHEKYQG 314 >4OLI-A nrPDB Length = 645 Score = 262 bits (670), Expect = 3e-70, Method: Composition-based stats. Identities = 93/299 (31%), Positives = 143/299 (47%), Gaps = 33/299 (11%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-----TRVAIKTLKPGT--MSPEAFLQ 312 D + L+ LG+G FG+V + ++ T VA+K LK + Q Sbjct: 345 SDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQ 404 Query: 313 EAQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDM 369 E +++ L HE +++ ++ + +V EY+ GSL D+L + + L QL+ Sbjct: 405 EIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHS---IGLAQLLLF 461 Query: 370 AAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE--YTARQGAKF 427 A QI GMAY+ +Y+HR+L A N+L+ + + K+ DFGLA+ + + Y R+ Sbjct: 462 AQQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDS 521 Query: 428 PIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKG----RVP--Y--------PGMVNRE 473 P+ W APE +F SDVWSFG+ L EL T P + M Sbjct: 522 PVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLR 581 Query: 474 VLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQP 532 + + +ERG R+P P +CP ++ LM CW E RPTFE L L + +YQ Sbjct: 582 LTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPIL----KTVHEKYQG 636 Score = 166 bits (420), Expect = 3e-41, Method: Composition-based stats. Identities = 80/316 (25%), Positives = 127/316 (40%), Gaps = 45/316 (14%) Query: 244 LTTVCPTSKPQTQGLAKDAWE-IPRESLRLEVKLGQGCFGEVWMGTWNGTT--------- 293 L + P+T L++ ++ + ++ + LGQG V+ G Sbjct: 20 LYFQGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKM 79 Query: 294 ----------------RVAIKTLKPGTMSPEAFLQE-AQVMKKLRHEKLVQLYAVVSEEP 336 RV +K L P E A +M ++ H L ++ V P Sbjct: 80 DDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGP 139 Query: 337 IYI-VTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANI 395 I VTEY+ G L +L+ E G ++ + + +A Q+AS ++Y+E N VH ++ NI Sbjct: 140 ENIMVTEYVEHGPLDVWLRRERG-HVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNI 198 Query: 396 LV-------GENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG--RFTIKS 446 L+ G + K++D G+ +R+ I W APE G + Sbjct: 199 LLARLGLAEGTSPFIKLSDPGV-----GLGALSREERVERIPWLAPECLPGGANSLSTAM 253 Query: 447 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEP 506 D W FG L E+ G P E +R +R+P P CP+ L L QC EP Sbjct: 254 DKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPS-CPQ-LATLTSQCLTYEP 311 Query: 507 EERPTFEYLQAFLEDY 522 +RP+F + L Sbjct: 312 TQRPSFRTILRDLTRL 327 >3COM-A nrPDB Length = 314 Score = 261 bits (667), Expect = 6e-70, Method: Composition-based stats. Identities = 68/257 (26%), Positives = 112/257 (43%), Gaps = 8/257 (3%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324 P E + KLG+G +G V+ T + VAIK + P + ++E +M++ Sbjct: 27 PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQV-PVESDLQEIIKEISIMQQCDSPH 85 Query: 325 LVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 +V+ Y ++IV EY GS+ D ++ K L ++ + G+ Y+ M Sbjct: 86 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLR-NKTLTEDEIATILQSTLKGLEYLHFM 144 Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443 +HRD++A NIL+ K+ADFG+A + D R W APE + Sbjct: 145 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDT-MAKRNTVIGTPFWMAPEVIQEIGYN 203 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPC--PPECPESLHDLMCQC 501 +D+WS GI E+ +G+ PY + + + P ++ D + QC Sbjct: 204 CVADIWSLGITAIEMA-EGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQC 262 Query: 502 WRKEPEERPTFEYLQAF 518 K PE+R T L Sbjct: 263 LVKSPEQRATATQLLQH 279 >5VO2-A nrPDB Length = 300 Score = 261 bits (666), Expect = 8e-70, Method: Composition-based stats. Identities = 79/266 (29%), Positives = 140/266 (52%), Gaps = 18/266 (6%) Query: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQV-- 316 ++D WE+P E + +G G G V++G ++G VA+K ++ L+E + Sbjct: 3 SEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHG-EEVAVKKVRD--------LKETDIKH 53 Query: 317 MKKLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIAS 375 ++KL+H ++ V ++ P Y I+ E+ ++G L + L+ G+ + LVD + IA Sbjct: 54 LRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRA--GRPVTPSLLVDWSMGIAG 111 Query: 376 GMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPE 435 GM Y+ +HRDL++ N+L+ + V K++DFG ++ + D + + + W APE Sbjct: 112 GMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDK--STKMSFAGTVAWMAPE 169 Query: 436 AALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMPCPPECPESL 494 + K D+WSFG++L EL T G +PY + + ++ V +P P CP+ Sbjct: 170 VIRNEPVSEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGF 228 Query: 495 HDLMCQCWRKEPEERPTFEYLQAFLE 520 L+ QCW +P RP+F + L+ Sbjct: 229 KILLRQCWNSKPRNRPSFRQILLHLD 254 >4E20-A nrPDB Length = 290 Score = 260 bits (664), Expect = 1e-69, Method: Composition-based stats. Identities = 91/286 (31%), Positives = 140/286 (48%), Gaps = 29/286 (10%) Query: 261 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGT-----TRVAIKTLKPGT--MSPEAFLQE 313 D + L+ LG+G FG+V + ++ T VA+K LK G + +E Sbjct: 1 DPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQRE 60 Query: 314 AQVMKKLRHEKLVQLYAVVSEEP---IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMA 370 ++++ L HE +V+ ++ + +V EY+ GSL D+L + L QL+ A Sbjct: 61 IEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHC---VGLAQLLLFA 117 Query: 371 AQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE--YTARQGAKFP 428 QI GMAY+ +Y+HR L A N+L+ + + K+ DFGLA+ + + Y R+ P Sbjct: 118 QQICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSP 177 Query: 429 IKWTAPEAALYGRFTIKSDVWSFGILLTELTTKG---RVPYPG-----------MVNREV 474 + W APE +F SDVWSFG+ L EL T + P+ M + Sbjct: 178 VFWYAPECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVLRL 237 Query: 475 LDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 + +ERG R+P P CP ++ LM CW E RPTF+ L L+ Sbjct: 238 TELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLVPILQ 283 >4UY9-A nrPDB Length = 323 Score = 259 bits (663), Expect = 2e-69, Method: Composition-based stats. Identities = 94/280 (33%), Positives = 131/280 (46%), Gaps = 26/280 (9%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPG-----TMSPEAFLQEAQVMK 318 EI L LE +G G FG+V+ W G VA+K + + + E QEA++ Sbjct: 5 EIDFAELTLEEIIGIGGFGKVYRAFWIG-DEVAVKAARHDPDEDISQTIENVRQEAKLFA 63 Query: 319 KLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 L+H ++ L V +EP + +V E+ G L L +GK + LV+ A QIA GM Sbjct: 64 MLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL---SGKRIPPDILVNWAVQIARGM 120 Query: 378 AYVERMNY---VHRDLRAANILVG--------ENLVCKVADFGLARLIEDNEYTARQGAK 426 Y+ +HRDL+++NIL+ N + K+ DFGLAR T + A Sbjct: 121 NYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWH---RTTKMSAA 177 Query: 427 FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREV-LDQVERGYRMP 485 W APE F+ SDVWS+G+LL EL T G VP+ G+ V +P Sbjct: 178 GTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMNKLALP 236 Query: 486 CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTS 525 P CPE LM CW +P RP+F + L S Sbjct: 237 IPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQLTTIEES 276 >4MVF-A nrPDB Length = 506 Score = 259 bits (662), Expect = 2e-69, Method: Composition-based stats. Identities = 74/269 (27%), Positives = 121/269 (44%), Gaps = 17/269 (6%) Query: 272 LEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP-EAFLQEAQVMKKLRHEKLVQLY 329 ++ KLGQG +G V+ G T + AIK K + F QE ++MKKL H +V+LY Sbjct: 61 IDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDHPNIVKLY 120 Query: 330 AVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 + IY++ E S L D + + QI S + Y+ +N VHR Sbjct: 121 ETYENDNYIYLIMELCSGRELFDSIIENGS--FTEKNAATIMKQIFSAIFYLHSLNIVHR 178 Query: 389 DLRAANILV---GENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445 DL+ N L ++ + K+ DFGL++ + E+T + AP+ G++ K Sbjct: 179 DLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFT--TTKAGTPYYVAPQVL-DGKYDKK 235 Query: 446 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPCPPECPESLHDLMCQCW 502 D+WS G+++ L G P+ G + EVL +V++G + +L+ + Sbjct: 236 CDIWSSGVIMYTLLC-GYPPFYGDTDNEVLKKVKKGEFCFYENDWGSISSDAKNLITKLL 294 Query: 503 RKEPEERPTFEYLQAFLEDYFTSTEPQYQ 531 P ER T E A + T ++ Sbjct: 295 TYNPNERCTIEE--ALNHPWITQMTKSHE 321 >4LRM-A nrPDB Length = 334 Score = 259 bits (661), Expect = 3e-69, Method: Composition-based stats. Identities = 90/276 (32%), Positives = 137/276 (49%), Gaps = 14/276 (5%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTW-----NGTTRVAIKTLKPGTMSP--EAFLQEAQVM 317 + + LG G FG V+ G W VAIK L+ T + L EA VM Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 75 Query: 318 KKLRHE---KLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 374 + + + +L + + ++T+ M G LLD+++ L++ QIA Sbjct: 76 ASVDNPGNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGS-QYLLNWCVQIA 134 Query: 375 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI-EDNEYTARQGAKFPIKWTA 433 GM Y+E VHRDL A N+LV K+ DFGLA+L+ + + +G K PIKW A Sbjct: 135 KGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMA 194 Query: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES 493 E+ L+ +T +SDVWS+G+ + EL T G PY G+ E+ +E+G R+P PP C Sbjct: 195 LESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTID 254 Query: 494 LHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 ++ +M +CW + + RP F L + +PQ Sbjct: 255 VYMIMVKCWMIDADSRPKFRELIIEFSKM--ARDPQ 288 >5JN2-A nrPDB Length = 525 Score = 258 bits (660), Expect = 3e-69, Method: Composition-based stats. Identities = 72/289 (24%), Positives = 134/289 (46%), Gaps = 24/289 (8%) Query: 258 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKP----GTMSPEAFLQ 312 + + I + + + LG+G FGEV + T + A+K + E+ L+ Sbjct: 57 FVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLR 116 Query: 313 EAQVMKKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA 371 E Q++K+L H +++LY ++ Y+V E + G L D + K + Sbjct: 117 EVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISR--KRFSEVDAARIIR 174 Query: 372 QIASGMAYVERMNYVHRDLRAANILV---GENLVCKVADFGLARLIEDNEYTARQGAKFP 428 Q+ SG+ Y+ + VHRDL+ N+L+ ++ ++ DFGL+ E ++ + Sbjct: 175 QVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASK--KMKDKIGT 232 Query: 429 IKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMP 485 + APE +G + K DVWS G++L L + G P+ G ++L +VE+G + +P Sbjct: 233 AYYIAPEVL-HGTYDEKCDVWSTGVILYILLS-GCPPFNGANEYDILKKVEKGKYTFELP 290 Query: 486 CPPECPESLHDLMCQCWRKEPEERPTF------EYLQAFLEDYFTSTEP 528 + ES DL+ + P R + E++Q + ++ + P Sbjct: 291 QWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQISVDVP 339 >3DTC-A nrPDB Length = 271 Score = 257 bits (658), Expect = 6e-69, Method: Composition-based stats. Identities = 93/274 (33%), Positives = 130/274 (47%), Gaps = 26/274 (9%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPG-----TMSPEAFLQEAQVMK 318 EI L LE +G G FG+V+ W G VA+K + + + E QEA++ Sbjct: 3 EIDFAELTLEEIIGIGGFGKVYRAFWIG-DEVAVKAARHDPDEDISQTIENVRQEAKLFA 61 Query: 319 KLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 L+H ++ L V +EP + +V E+ G L L +GK + LV+ A QIA GM Sbjct: 62 MLKHPNIIALRGVCLKEPNLCLVMEFARGGPLNRVL---SGKRIPPDILVNWAVQIARGM 118 Query: 378 AYVERMNY---VHRDLRAANILVG--------ENLVCKVADFGLARLIEDNEYTARQGAK 426 Y+ +HRDL+++NIL+ N + K+ DFGLAR T + A Sbjct: 119 NYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWH---RTTKMSAA 175 Query: 427 FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREV-LDQVERGYRMP 485 W APE F+ SDVWS+G+LL EL T G VP+ G+ V +P Sbjct: 176 GAYAWMAPEVIRASMFSKGSDVWSYGVLLWELLT-GEVPFRGIDGLAVAYGVAMNKLALP 234 Query: 486 CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFL 519 P CPE LM CW +P RP+F + L Sbjct: 235 IPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL 268 >4CFF-A nrPDB Length = 571 Score = 257 bits (658), Expect = 7e-69, Method: Composition-based stats. Identities = 73/278 (26%), Positives = 126/278 (45%), Gaps = 15/278 (5%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSPEA----FLQEA 314 K + L LG G FG+V +G T +VA+K L + +E Sbjct: 25 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 84 Query: 315 QVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373 Q +K RH +++LY V+ + ++V EY+S G L D++ + + + QI Sbjct: 85 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQI 142 Query: 374 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 433 S + Y R VHRDL+ N+L+ ++ K+ADFGL+ ++ D E+ R P + A Sbjct: 143 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF-LRTSCGSP-NYAA 200 Query: 434 PEAALYGRF-TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE 492 PE + + D+WS G++L L G +P+ + ++ RG P Sbjct: 201 PEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNR 258 Query: 493 SLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 S+ L+ + +P +R T + ++ ++F P Y Sbjct: 259 SVATLLMHMLQVDPLKRATIKDIRE--HEWFKQDLPSY 294 >2YZA-A nrPDB Length = 276 Score = 257 bits (657), Expect = 8e-69, Method: Composition-based stats. Identities = 73/279 (26%), Positives = 127/279 (45%), Gaps = 15/279 (5%) Query: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSPEA----FLQE 313 +K + L LG G FG+V +G T +VA+K L + +E Sbjct: 2 SKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKRE 61 Query: 314 AQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQ 372 Q +K RH +++LY V+ + ++V EY+S G L D++ + + + Q Sbjct: 62 IQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQ 119 Query: 373 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT 432 I S + Y R VHRDL+ N+L+ ++ K+ADFGL+ ++ D E+ R P + Sbjct: 120 ILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF-LRDSCGSP-NYA 177 Query: 433 APEAALYGRF-TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP 491 APE + + D+WS G++L L G +P+ + ++ RG P Sbjct: 178 APEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLN 235 Query: 492 ESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 S+ L+ + +P +R T + ++ ++F P Y Sbjct: 236 RSVATLLMHMLQVDPLKRATIKDIRE--HEWFKQDLPSY 272 >3MN3-A nrPDB Length = 271 Score = 257 bits (656), Expect = 1e-68, Method: Composition-based stats. Identities = 65/270 (24%), Positives = 119/270 (44%), Gaps = 16/270 (5%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSPEAFL----QEAQVMKKLRH 322 + ++ LG+G FG+V + T +VA+K + ++ +E ++ LRH Sbjct: 4 GNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIEREISYLRLLRH 63 Query: 323 EKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 +++LY V+ S++ I +V EY L D++ + + QI S + Y Sbjct: 64 PHIIKLYDVIKSKDEIIMVIEYA-GNELFDYIVQRD--KMSEQEARRFFQQIISAVEYCH 120 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 R VHRDL+ N+L+ E+L K+ADFGL+ ++ D + + + APE Sbjct: 121 RHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLK--TSCGSPNYAAPEVISGKL 178 Query: 442 F-TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQ 500 + + DVWS G++L + + R+P+ + + G P L+ + Sbjct: 179 YAGPEVDVWSCGVILYVMLCR-RLPFDDESIPVLFKNISNGV-YTLPKFLSPGAAGLIKR 236 Query: 501 CWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 P R + + +D+F P+Y Sbjct: 237 MLIVNPLNRISIHEIMQ--DDWFKVDLPEY 264 >5HI2-A nrPDB Length = 283 Score = 257 bits (656), Expect = 1e-68, Method: Composition-based stats. Identities = 89/274 (32%), Positives = 146/274 (53%), Gaps = 15/274 (5%) Query: 258 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVM 317 + D WEIP + + ++G G FG V+ G W+G VA+K L P + +AF E V+ Sbjct: 10 DSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD--VAVKMLTPQQL--QAFKNEVGVL 65 Query: 318 KKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 +K RH ++ ++ + IVT++ SL L K + +L+D+A Q A GM Sbjct: 66 RKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETK-FEMKKLIDIARQTARGM 124 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEA 436 Y+ + +HRDL++ NI + E+ K+ DFGLA + + + I W APE Sbjct: 125 DYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEV 184 Query: 437 AL---YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR-EVLDQVERGYRMP----CPP 488 ++ +SDV++FGI+L EL T G++PY + NR ++++ V RG P Sbjct: 185 IRMQDSNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIEMVGRGSLSPDLSKVRS 243 Query: 489 ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 CP+ + LM +C +K+ +ERP+F + A +E+ Sbjct: 244 NCPKRMKRLMAECLKKKRDERPSFPRILAEIEEL 277 >5EZV-A nrPDB Length = 560 Score = 256 bits (655), Expect = 1e-68, Method: Composition-based stats. Identities = 73/278 (26%), Positives = 126/278 (45%), Gaps = 15/278 (5%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSPEA----FLQEA 314 K + L LG G FG+V +G T +VA+K L + +E Sbjct: 20 KHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREI 79 Query: 315 QVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373 Q +K RH +++LY V+ + ++V EY+S G L D++ + + + QI Sbjct: 80 QNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQI 137 Query: 374 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 433 S + Y R VHRDL+ N+L+ ++ K+ADFGL+ ++ D E+ R P + A Sbjct: 138 LSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF-LRTSCGSP-NYAA 195 Query: 434 PEAALYGRF-TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE 492 PE + + D+WS G++L L G +P+ + ++ RG P Sbjct: 196 PEVISGRLYAGPEVDIWSCGVILYALLC-GTLPFDDEHVPTLFKKI-RGGVFYIPEYLNR 253 Query: 493 SLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 S+ L+ + +P +R T + ++ ++F P Y Sbjct: 254 SVATLLMHMLQVDPLKRATIKDIRE--HEWFKQDLPSY 289 >4LG4-A nrPDB Length = 299 Score = 256 bits (654), Expect = 2e-68, Method: Composition-based stats. Identities = 66/267 (24%), Positives = 115/267 (43%), Gaps = 10/267 (3%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324 P E + KLG+G +G V+ + +V AIK + P + ++E +M++ Sbjct: 9 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV-PVESDLQEIIKEISIMQQCDSPY 67 Query: 325 LVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 +V+ Y ++IV EY GS+ D ++ K L ++ + G+ Y+ M Sbjct: 68 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLR-NKTLIEDEIATILKSTLKGLEYLHFM 126 Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443 +HR+++A NIL+ K+ADFG+A + D R W APE + Sbjct: 127 RKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDT-MAKRNTVIGTPFWMAPEVIQEIGYN 185 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPC--PPECPESLHDLMCQC 501 +D+WS GI E+ +G+ PY + + + P + D + +C Sbjct: 186 CVADIWSLGITSIEMA-EGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKC 244 Query: 502 WRKEPEERPTFEYLQAFLEDYFTSTEP 528 K PE+R T L + + +P Sbjct: 245 LVKNPEQRATATQLLQ--HPFIKNAKP 269 >4REW-A nrPDB Length = 540 Score = 256 bits (654), Expect = 2e-68, Method: Composition-based stats. Identities = 73/274 (26%), Positives = 127/274 (46%), Gaps = 15/274 (5%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSPEA----FLQEAQVMK 318 + L LG G FG+V +G T +VA+K L + +E Q +K Sbjct: 2 SVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLK 61 Query: 319 KLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 RH +++LY V+ + I++V EY+S G L D++ L + + QI SG+ Sbjct: 62 LFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYI--CKNGRLDEKESRRLFQQILSGV 119 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 437 Y R VHRDL+ N+L+ ++ K+ADFGL+ ++ D E+ R P + APE Sbjct: 120 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF-LRTSCGSP-NYAAPEVI 177 Query: 438 LYGRF-TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 + + D+WS G++L L G +P+ + ++ G P S+ Sbjct: 178 SGRLYAGPEVDIWSSGVILYALLC-GTLPFDDDHVPTLFKKICDGIFYT-PQYLNPSVIS 235 Query: 497 LMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 L+ + +P +R + + ++ ++F P+Y Sbjct: 236 LLKHMLQVDPMKRASIKDIRE--HEWFKQDLPKY 267 >4CFH-A nrPDB Length = 493 Score = 256 bits (654), Expect = 2e-68, Method: Composition-based stats. Identities = 73/278 (26%), Positives = 127/278 (45%), Gaps = 15/278 (5%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSPEA----FLQEA 314 K + L LG G FG+V +G T +VA+K L + +E Sbjct: 25 KHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREI 84 Query: 315 QVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373 Q +K RH +++LY V+ + I++V EY+S G L D++ L + + QI Sbjct: 85 QNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYI--CKNGRLDEKESRRLFQQI 142 Query: 374 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 433 SG+ Y R VHRDL+ N+L+ ++ K+ADFGL+ ++ D E+ + + A Sbjct: 143 LSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLR--TSCGSPNYAA 200 Query: 434 PEAALYGRF-TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE 492 PE + + D+WS G++L L G +P+ + ++ G P Sbjct: 201 PEVISGRLYAGPEVDIWSSGVILYALLC-GTLPFDDDHVPTLFKKICDGIFYT-PQYLNP 258 Query: 493 SLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 S+ L+ + +P +R T + ++ ++F P+Y Sbjct: 259 SVISLLKHMLQVDPMKRATIKDIRE--HEWFKQDLPKY 294 >5HIE-A nrPDB Length = 302 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 92/285 (32%), Positives = 150/285 (52%), Gaps = 16/285 (5%) Query: 256 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQ 315 + + D WEIP + + ++G G FG V+ G W+G VA+K L P + +AF E Sbjct: 24 RRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD--VAVKMLTPQQL--QAFKNEVG 79 Query: 316 VMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIAS 375 V++K RH ++ ++ + IVT++ SL L K + +L+D+A Q A Sbjct: 80 VLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETK-FEMIKLIDIARQTAQ 138 Query: 376 GMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAP 434 GM Y+ + +HRDL++ NI + E+L K+ DFGLA + + + I W AP Sbjct: 139 GMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAP 198 Query: 435 EAAL---YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR-EVLDQVERGYRMP----C 486 E ++ +SDV++FGI+L EL T G++PY + NR +++ V RGY P Sbjct: 199 EVIRMQDKNPYSFQSDVYAFGIVLYELMT-GQLPYSNINNRDQIIFMVGRGYLSPDLSKV 257 Query: 487 PPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQ 531 CP+++ LM +C +K+ +ERP F + A +E + P+ Sbjct: 258 RSNCPKAMKRLMAECLKKKRDERPLFPQILASIE-LLARSLPKIH 301 >6AO5-A nrPDB Length = 362 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 66/267 (24%), Positives = 115/267 (43%), Gaps = 10/267 (3%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324 P E + KLG+G +G V+ + +V AIK + P + ++E +M++ Sbjct: 8 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV-PVESDLQEIIKEISIMQQCDSPY 66 Query: 325 LVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 +V+ Y ++IV EY GS+ D ++ K L ++ + G+ Y+ M Sbjct: 67 VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLR-NKTLIEDEIATILKSTLKGLEYLHFM 125 Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443 +HR+++A NIL+ K+ADFG+A + D R W APE + Sbjct: 126 RKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDT-MAKRNTVIGTPFWMAPEVIQEIGYN 184 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPC--PPECPESLHDLMCQC 501 +D+WS GI E+ +G+ PY + + + P + D + +C Sbjct: 185 CVADIWSLGITSIEMA-EGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKC 243 Query: 502 WRKEPEERPTFEYLQAFLEDYFTSTEP 528 K PE+R T L + + +P Sbjct: 244 LVKNPEQRATATQLLQ--HPFIKNAKP 268 >4RED-A nrPDB Length = 351 Score = 255 bits (652), Expect = 3e-68, Method: Composition-based stats. Identities = 73/274 (26%), Positives = 126/274 (45%), Gaps = 15/274 (5%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEA----FLQEAQVMK 318 + L LG G FG+V +G T VA+K L + +E Q +K Sbjct: 10 SVKIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLK 69 Query: 319 KLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 RH +++LY V+ + I++V EY+S G L D++ L + + QI SG+ Sbjct: 70 LFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYI--CKNGRLDEKESRRLFQQILSGV 127 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 437 Y R VHRDL+ N+L+ ++ K+ADFGL+ ++ D E+ R P + APE Sbjct: 128 DYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF-LRTSCGSP-NYAAPEVI 185 Query: 438 LYGRF-TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 + + D+WS G++L L G +P+ + ++ G P S+ Sbjct: 186 SGRLYAGPEVDIWSSGVILYALLC-GTLPFDDDHVPTLFKKICDGIFYT-PQYLNPSVIS 243 Query: 497 LMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 L+ + +P +R + + ++ ++F P+Y Sbjct: 244 LLKHMLQVDPMKRASIKDIRE--HEWFKQDLPKY 275 >4QMW-A nrPDB Length = 310 Score = 255 bits (651), Expect = 4e-68, Method: Composition-based stats. Identities = 80/286 (27%), Positives = 126/286 (44%), Gaps = 13/286 (4%) Query: 237 ADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV- 295 G + + P Q L D P E K+G+G FGEV+ G N T +V Sbjct: 2 PLGSEFMAHSPVQSGLPGMQNLKAD----PEELFTKLEKIGKGSFGEVFKGIDNRTQKVV 57 Query: 296 AIKTLK--PGTMSPEAFLQEAQVMKKLRHEKLVQLYA-VVSEEPIYIVTEYMSKGSLLDF 352 AIK + E QE V+ + + + Y + + ++I+ EY+ GS LD Sbjct: 58 AIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDL 117 Query: 353 LKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR 412 L+ L Q+ + +I G+ Y+ +HRD++AAN+L+ E+ K+ADFG+A Sbjct: 118 LE---PGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAG 174 Query: 413 LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR 472 + D + P W APE + K+D+WS GI EL +G P+ + Sbjct: 175 QLTDTQIKRNTFVGTPF-WMAPEVIKQSAYDSKADIWSLGITAIELA-RGEPPHSELHPM 232 Query: 473 EVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAF 518 +VL + + + L + + C KEP RPT + L Sbjct: 233 KVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKH 278 >3Q5I-A nrPDB Length = 504 Score = 254 bits (650), Expect = 5e-68, Method: Composition-based stats. Identities = 64/279 (22%), Positives = 115/279 (41%), Gaps = 29/279 (10%) Query: 258 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSP--------- 307 + K +I ++ KLG G +GEV + AIK +K Sbjct: 27 VRKKEGKIGESYFKV-RKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKN 85 Query: 308 -----EAFLQEAQVMKKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYL 361 E E ++K L H +++L+ V ++ Y+VTE+ G L + + Sbjct: 86 IEKFHEEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINR--HKF 143 Query: 362 RLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENL---VCKVADFGLARLIEDNE 418 ++ QI SG+ Y+ + N VHRD++ NIL+ K+ DFGL+ + Sbjct: 144 DECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKD- 202 Query: 419 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 + + APE ++ K DVWS G+++ L G P+ G +++++ +V Sbjct: 203 -YKLRDRLGTAYYIAPEVL-KKKYNEKCDVWSCGVIMYILLC-GYPPFGGQNDQDIIKKV 259 Query: 479 ERG---YRMPCPPECPESLHDLMCQCWRKEPEERPTFEY 514 E+G + + +L+ + +R T E Sbjct: 260 EKGKYYFDFNDWKNISDEAKELIKLMLTYDYNKRCTAEE 298 >3HZT-A nrPDB Length = 467 Score = 254 bits (650), Expect = 5e-68, Method: Composition-based stats. Identities = 71/259 (27%), Positives = 117/259 (45%), Gaps = 18/259 (6%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSPE----AFLQEAQVMKKLRH 322 + + KLG G +GEV + T AIK +K +++ A L E V+K+L H Sbjct: 4 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 63 Query: 323 EKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 +++LY ++ Y+V E G L D + + + Q+ SG Y+ Sbjct: 64 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILR--QKFSEVDAAVIMKQVLSGTTYLH 121 Query: 382 RMNYVHRDLRAANILV---GENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438 + N VHRDL+ N+L+ + + K+ DFGL+ E + + APE Sbjct: 122 KHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKER--LGTAYYIAPEVLR 179 Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC---PESLH 495 ++ K DVWS G++L L G P+ G ++E+L +VE+G PP+ + Sbjct: 180 -KKYDEKCDVWSCGVILYILLC-GYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAK 237 Query: 496 DLMCQCWRKEPEERPTFEY 514 L+ EP +R + E Sbjct: 238 QLVKLMLTYEPSKRISAEE 256 >5ES1-A nrPDB Length = 328 Score = 254 bits (650), Expect = 6e-68, Method: Composition-based stats. Identities = 71/256 (27%), Positives = 124/256 (48%), Gaps = 14/256 (5%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP---EAFLQEAQVMKKLRHE 323 + RL +G+G F +V + T R VAIK + ++P + +E ++MK L H Sbjct: 15 GNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHP 74 Query: 324 KLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V+L+ V+ +E+ +Y+V EY S G + D+L ++ + QI S + Y + Sbjct: 75 NIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGR--MKEKEARAKFRQIVSAVHYCHQ 132 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 N VHRDL+A N+L+ K+ADFG + + + APE ++ Sbjct: 133 KNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLG--SKLDTFCGSPPYAAPELFQGKKY 190 Query: 443 T-IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMPCPPECPESLHDLMCQ 500 + D+WS G++L L + G +P+ G +E+ ++V RG YR+P ++ + Sbjct: 191 DGPEVDIWSLGVILYTLVS-GSLPFDGHNLKELRERVLRGKYRVPF--YMSTDCESILRR 247 Query: 501 CWRKEPEERPTFEYLQ 516 P +R T E + Sbjct: 248 FLVLNPAKRCTLEQIM 263 >4UYA-A nrPDB Length = 340 Score = 254 bits (649), Expect = 7e-68, Method: Composition-based stats. Identities = 90/280 (32%), Positives = 133/280 (47%), Gaps = 26/280 (9%) Query: 258 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSP-----EAFLQ 312 + E L L+ +G G FG+V+ TW G VA+K + E+ + Sbjct: 16 FQGSPVHVAFERLELKELIGAGGFGQVYRATWQG-QEVAVKAARQDPEQDAAAAAESVRR 74 Query: 313 EAQVMKKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA 371 EA++ LRH +++L V ++P + +V E+ G+L L G+ + LV+ A Sbjct: 75 EARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRAL---AGRRIPPHVLVNWAV 131 Query: 372 QIASGMAYVERMN---YVHRDLRAANILVGE--------NLVCKVADFGLARLIEDNEYT 420 QIA GM Y+ +HRDL+++NIL+ E N K+ DFGLAR T Sbjct: 132 QIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWH---RT 188 Query: 421 ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREV-LDQVE 479 + W APE F+ SD+WS+G+LL EL T G VPY G+ V Sbjct: 189 TKMATAGAYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLT-GEVPYRGIDGLAVAYGVAV 247 Query: 480 RGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFL 519 +P P CPE LM +CW+++P RP+F + L Sbjct: 248 NKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQL 287 >2QNJ-A nrPDB Length = 328 Score = 254 bits (649), Expect = 7e-68, Method: Composition-based stats. Identities = 71/256 (27%), Positives = 125/256 (48%), Gaps = 14/256 (5%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP---EAFLQEAQVMKKLRHE 323 + RL +G+G F +V + T R VAIK + ++P + +E ++MK L H Sbjct: 12 GNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHP 71 Query: 324 KLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V+L+ V+ +E+ +Y++ EY S G + D+L ++ + QI S + Y + Sbjct: 72 NIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGR--MKEKEARSKFRQIVSAVQYCHQ 129 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 VHRDL+A N+L+ ++ K+ADFG + + APE ++ Sbjct: 130 KRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGG--KLDTFCGSPPYAAPELFQGKKY 187 Query: 443 T-IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMPCPPECPESLHDLMCQ 500 + DVWS G++L L + G +P+ G +E+ ++V RG YR+P +L+ + Sbjct: 188 DGPEVDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGKYRIPF--YMSTDCENLLKR 244 Query: 501 CWRKEPEERPTFEYLQ 516 P +R T E + Sbjct: 245 FLVLNPIKRGTLEQIM 260 >3DXN-A nrPDB Length = 287 Score = 254 bits (648), Expect = 8e-68, Method: Composition-based stats. Identities = 71/259 (27%), Positives = 117/259 (45%), Gaps = 18/259 (6%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSPE----AFLQEAQVMKKLRH 322 + + KLG G +GEV + T AIK +K +++ A L E V+K+L H Sbjct: 21 DRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVLKQLDH 80 Query: 323 EKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 +++LY ++ Y+V E G L D + + + Q+ SG Y+ Sbjct: 81 PNIMKLYEFFEDKRNYYLVMEVYRGGELFDEIILR--QKFSEVDAAVIMKQVLSGTTYLH 138 Query: 382 RMNYVHRDLRAANILV---GENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438 + N VHRDL+ N+L+ + + K+ DFGL+ E + + APE Sbjct: 139 KHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKER--LGTAYYIAPEVLR 196 Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC---PESLH 495 ++ K DVWS G++L L G P+ G ++E+L +VE+G PP+ + Sbjct: 197 -KKYDEKCDVWSCGVILYILLC-GYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVSDEAK 254 Query: 496 DLMCQCWRKEPEERPTFEY 514 L+ EP +R + E Sbjct: 255 QLVKLMLTYEPSKRISAEE 273 >3MA6-A nrPDB Length = 298 Score = 254 bits (648), Expect = 8e-68, Method: Composition-based stats. Identities = 71/282 (25%), Positives = 132/282 (46%), Gaps = 24/282 (8%) Query: 258 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKP----GTMSPEAFLQ 312 + + I + + + LG+G FGEV + T + A+K + E+ L+ Sbjct: 22 FVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLR 81 Query: 313 EAQVMKKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA 371 E Q++K+L H +++LY ++ Y+V E + G L D + K + Sbjct: 82 EVQLLKQLDHPNIMKLYEFFEDKGYFYLVGEVYTGGELFDEIISR--KRFSEVDAARIIR 139 Query: 372 QIASGMAYVERMNYVHRDLRAANILV---GENLVCKVADFGLARLIEDNEYTARQGAKFP 428 Q+ SG+ Y+ + VHRDL+ N+L+ ++ ++ DFGL+ E ++ + Sbjct: 140 QVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASK--KMKDKIGT 197 Query: 429 IKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMP 485 + APE +G + K DVWS G++L L + G P+ G ++L +VE+G + +P Sbjct: 198 AYYIAPEVL-HGTYDEKCDVWSTGVILYILLS-GCPPFNGANEYDILKKVEKGKYTFELP 255 Query: 486 CPPECPESLHDLMCQCWRKEPEERPTF------EYLQAFLED 521 + ES DL+ + P R + E++Q + ++ Sbjct: 256 QWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKE 297 >5WNO-A nrPDB Length = 330 Score = 254 bits (648), Expect = 1e-67, Method: Composition-based stats. Identities = 91/272 (33%), Positives = 141/272 (51%), Gaps = 11/272 (4%) Query: 265 IPRESL--RLEVKLGQGCFGEVWMGTW------NGTTRVAIKTLKPGTMSPEAFLQEAQV 316 IP L +L+ KLG G FG V+ G + N VAIK + + L+EA Sbjct: 17 IPSSELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATN 76 Query: 317 MKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIAS 375 M +LRH+ L+++ ++ + IVT Y G+L +FLK + L + V QIAS Sbjct: 77 MFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHK-ENLGAREQVLYCYQIAS 135 Query: 376 GMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI-EDNEYTARQGAKFPIKWTAP 434 GM Y+E+ VHRDL N+LV + ++ DFGL++++ D + + K IKW A Sbjct: 136 GMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLAI 195 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESL 494 E +T SDVW+FG+ E+ T G+ PY GM + + ++ G R+ PP C + L Sbjct: 196 EIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDL 255 Query: 495 HDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 + + +CW +P+ RP FE L +++ Sbjct: 256 YQELLRCWMADPKSRPGFEILYERFKEFCKVP 287 >3IO7-A nrPDB Length = 313 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 81/288 (28%), Positives = 142/288 (49%), Gaps = 27/288 (9%) Query: 261 DAWEIPRESLRLEVKLGQGCFGEVWMGT-----WNGTTRVAIKTLKPGTMSP-EAFLQEA 314 + + L+ +LG+G FG V M N VA+K L+ T F +E Sbjct: 21 NMTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREI 80 Query: 315 QVMKKLRHEKLVQLYAVV---SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA 371 +++K L+H+ +V+ V + ++ EY+ GSL D+L+ + + +L+ + Sbjct: 81 EILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKER-IDHIKLLQYTS 139 Query: 372 QIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE--YTARQGAKFPI 429 QI GM Y+ Y+HRDL NILV K+ DFGL +++ ++ Y ++ + PI Sbjct: 140 QICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPI 199 Query: 430 KWTAPEAALYGRFTIKSDVWSFGILLTELTTK----GRVP--YPGMVNRE---------V 474 W APE+ +F++ SDVWSFG++L EL T P + M+ + + Sbjct: 200 FWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHL 259 Query: 475 LDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 ++ ++ R+P P CP+ ++ +M +CW +RP+F L ++ Sbjct: 260 IELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQI 307 >2W1I-A nrPDB Length = 326 Score = 253 bits (646), Expect = 2e-67, Method: Composition-based stats. Identities = 82/289 (28%), Positives = 143/289 (49%), Gaps = 27/289 (9%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMGT-----WNGTTRVAIKTLKPGTMSP-EAFLQE 313 +D + L+ +LG+G FG V M N VA+K L+ T F +E Sbjct: 33 RDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFERE 92 Query: 314 AQVMKKLRHEKLVQLYAVV---SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMA 370 +++K L+H+ +V+ V + ++ EY+ GSL D+L+ + + +L+ Sbjct: 93 IEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKER-IDHIKLLQYT 151 Query: 371 AQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE--YTARQGAKFP 428 +QI GM Y+ Y+HRDL NILV K+ DFGL +++ ++ Y ++ + P Sbjct: 152 SQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESP 211 Query: 429 IKWTAPEAALYGRFTIKSDVWSFGILLTELTTK----GRVP--YPGMVNRE--------- 473 I W APE+ +F++ SDVWSFG++L EL T P + M+ + Sbjct: 212 IFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFH 271 Query: 474 VLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 +++ ++ R+P P CP+ ++ +M +CW +RP+F L ++ Sbjct: 272 LIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQI 320 >3OMV-A nrPDB Length = 307 Score = 252 bits (645), Expect = 2e-67, Method: Composition-based stats. Identities = 94/281 (33%), Positives = 149/281 (53%), Gaps = 16/281 (5%) Query: 252 KPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPE--- 308 +P+ Q + WEI + L ++G G FG V+ G W+G VA+K LK +PE Sbjct: 20 RPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGD--VAVKILKVVDPTPEQFQ 77 Query: 309 AFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD 368 AF E V++K RH ++ ++++ + IVT++ SL L + K ++ QL+D Sbjct: 78 AFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETK-FQMFQLID 136 Query: 369 MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK-F 427 +A Q A GM Y+ N +HRD+++ NI + E L K+ DFGLA + + + Sbjct: 137 IARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTG 196 Query: 428 PIKWTAPEAAL---YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR-EVLDQVERGYR 483 + W APE F+ +SDV+S+GI+L EL T G +PY + NR +++ V RGY Sbjct: 197 SVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMT-GELPYSHINNRDQIIFMVGRGYA 255 Query: 484 MP----CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 P CP+++ L+ C +K EERP F + + +E Sbjct: 256 SPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIE 296 >5KZ7-A nrPDB Length = 346 Score = 252 bits (643), Expect = 4e-67, Method: Composition-based stats. Identities = 69/256 (26%), Positives = 124/256 (48%), Gaps = 14/256 (5%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP---EAFLQEAQVMKKLRHE 323 + RL +G+G F +V + T + VA+K + ++ + +E ++MK L H Sbjct: 33 GNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHP 92 Query: 324 KLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V+L+ V+ +E+ +Y+V EY S G + D+L ++ + QI S + Y + Sbjct: 93 NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR--MKEKEARAKFRQIVSAVQYCHQ 150 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 VHRDL+A N+L+ ++ K+ADFG + + APE ++ Sbjct: 151 KFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFG--NKLDTFCGSPPYAAPELFQGKKY 208 Query: 443 T-IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMPCPPECPESLHDLMCQ 500 + DVWS G++L L + G +P+ G +E+ ++V RG YR+P +L+ + Sbjct: 209 DGPEVDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGKYRIPF--YMSTDCENLLKK 265 Query: 501 CWRKEPEERPTFEYLQ 516 P +R T E + Sbjct: 266 FLILNPSKRGTLEQIM 281 >5IG1-A nrPDB Length = 344 Score = 251 bits (641), Expect = 6e-67, Method: Composition-based stats. Identities = 65/277 (23%), Positives = 114/277 (41%), Gaps = 18/277 (6%) Query: 253 PQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEAF- 310 +T+ D +++ + R +G+G F V T V A+K + ++ Sbjct: 4 METETSFFDLYDVDLKDKR--SVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEIN 61 Query: 311 --LQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLV 367 +E + L+HE +V + +E Y+V EY+S G L D + K+ Sbjct: 62 KIKREIGICSSLQHEHIVSMRRAFRDESHFYLVFEYVSGGELFDEIVTR--KFYNEKDAS 119 Query: 368 DMAAQIASGMAYVERMNYVHRDLRAANILV---GENLVCKVADFGLARLIEDNEYTARQG 424 QI S + + N +HRDL+ N+L+ N K+ DFGLA ++E G Sbjct: 120 ACMHQILSALQHCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGP--TYFG 177 Query: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER-GYR 483 + +PE + DVW+ G++L L G P+ ++++ Q++ Y Sbjct: 178 FAGTPGYLSPEVIRRVPYDTAVDVWACGVILYILLV-GYPPFWEEDHQKLYAQIKNCQYD 236 Query: 484 MPCP--PECPESLHDLMCQCWRKEPEERPTFEYLQAF 518 P P + +L+ P+ RPT + L Sbjct: 237 FPSPEWDSVTTAAKELIKAMLEPNPKRRPTVQELLQH 273 >3LIJ-A nrPDB Length = 494 Score = 251 bits (640), Expect = 7e-67, Method: Composition-based stats. Identities = 74/274 (27%), Positives = 124/274 (45%), Gaps = 19/274 (6%) Query: 274 VKLGQGCFGEVWMGTWNGTT-RVAIKTLKP---GTMSPEAFLQEAQVMKKLRHEKLVQLY 329 KLG G +GEV + T AIK ++ T S L+E V+K L H +++LY Sbjct: 43 KKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNSKLLEEVAVLKLLDHPNIMKLY 102 Query: 330 AVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 ++ Y+V E G L D + + Q+ SG+ Y+ + N VHR Sbjct: 103 DFFEDKRNYYLVMECYKGGELFDEIIHRM--KFNEVDAAVIIKQVLSGVTYLHKHNIVHR 160 Query: 389 DLRAANILVGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445 DL+ N+L+ + + K+ DFGL+ + E+ + + + APE ++ K Sbjct: 161 DLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKER--LGTAYYIAPEVLR-KKYDEK 217 Query: 446 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPCPPECPESLHDLMCQCW 502 DVWS G++L L G P+ G ++E+L +VE+G + P E DL+ Q Sbjct: 218 CDVWSIGVILFILLA-GYPPFGGQTDQEILRKVEKGKYTFDSPEWKNVSEGAKDLIKQML 276 Query: 503 RKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536 + + + R + + QA + + + G L Sbjct: 277 QFDSQRRISAQ--QALEHPWIKEMCSKKESGIEL 308 >3H4J-B nrPDB Length = 336 Score = 250 bits (638), Expect = 1e-66, Method: Composition-based stats. Identities = 69/266 (25%), Positives = 120/266 (45%), Gaps = 16/266 (6%) Query: 272 LEVKLGQGCFGEVWMGTWNGTT-RVAIKTLK----PGTMSPEAFLQEAQVMKKLRHEKLV 326 + LG+G FG+V + T T +VA+K + + +E +K LRH ++ Sbjct: 13 IRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMHMRVEREISYLKLLRHPHII 72 Query: 327 QLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 +LY V++ I +V EY G L D++ + K + + QI + Y R Sbjct: 73 KLYDVITTPTDIVMVIEYA-GGELFDYIVEK--KRMTEDEGRRFFQQIICAIEYCHRHKI 129 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF-TI 444 VHRDL+ N+L+ +NL K+ADFGL+ ++ D + + + APE + Sbjct: 130 VHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLK--TSCGSPNYAAPEVINGKLYAGP 187 Query: 445 KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRK 504 + DVWS GI+L + GR+P+ + +V + P L+ + Sbjct: 188 EVDVWSCGIVLYVMLV-GRLPFDDEFIPNLFKKVNSCVYV-MPDFLSPGAQSLIRRMIVA 245 Query: 505 EPEERPTFEYLQAFLEDYFTSTEPQY 530 +P +R T + ++ + +F P Y Sbjct: 246 DPMQRITIQEIRR--DPWFNVNLPDY 269 >2WQN-A nrPDB Length = 310 Score = 249 bits (637), Expect = 2e-66, Method: Composition-based stats. Identities = 69/280 (24%), Positives = 122/280 (43%), Gaps = 14/280 (5%) Query: 247 VCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMG-TWNGTTRVAIKTLKP--- 302 P +PQ + L D + R+E K+G+G F EV+ VA+K ++ Sbjct: 12 PVPQFQPQ-KALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDL 70 Query: 303 -GTMSPEAFLQEAQVMKKLRHEKLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLK--GETG 358 + ++E ++K+L H +++ YA + + + IV E G L +K + Sbjct: 71 MDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQK 130 Query: 359 KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE 418 + + + Q+ S + ++ +HRD++ AN+ + V K+ D GL R Sbjct: 131 RLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKT 190 Query: 419 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPG--MVNREVLD 476 TA + +PE + KSD+WS G LL E+ + P+ G M + Sbjct: 191 -TAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAAL-QSPFYGDKMNLYSLCK 248 Query: 477 QVERGYRMPCPPE-CPESLHDLMCQCWRKEPEERPTFEYL 515 ++E+ P P + E L L+ C +PE+RP Y+ Sbjct: 249 KIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYV 288 >4CZT-A nrPDB Length = 464 Score = 249 bits (635), Expect = 3e-66, Method: Composition-based stats. Identities = 63/264 (23%), Positives = 109/264 (41%), Gaps = 14/264 (5%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPE----AFLQEAQVMKKLRHEK 324 L LG+G F +V VAIK + + +E MK ++H Sbjct: 13 YELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMIAQIKREISTMKLIKHPN 72 Query: 325 LVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 +++++ V+ S+ IY V E+++ G L D + L+ + Q+ + + Y Sbjct: 73 VIRMFEVMASKTKIYFVLEFVTGGELFDKISSNGR--LKEDEARKYFQQLINAVDYCHSR 130 Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAALYGRF 442 HRDL+ N+L+ N KV+DFGL+ L + E + APE + Sbjct: 131 GVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPEVINNKGY 190 Query: 443 T-IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 501 K+D+WS G++L L G +P+ + ++ + CPP S L+ + Sbjct: 191 DGAKADLWSCGVILFVLMA-GYLPFEDSNLTSLYKKIFKA-EFTCPPWFSASAKKLIKRI 248 Query: 502 WRKEPEERPTFEYLQAFLEDYFTS 525 P R TF + ++F Sbjct: 249 LDPNPATRITFAEVIE--NEWFKK 270 >5D9K-A nrPDB Length = 330 Score = 248 bits (634), Expect = 4e-66, Method: Composition-based stats. Identities = 66/287 (22%), Positives = 130/287 (45%), Gaps = 20/287 (6%) Query: 255 TQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTW----NGTTRVAIKTLKPGTMSPEAF 310 T + + + L LGQG FG+V++ + A+K LK T+ Sbjct: 17 THHVKEGHEKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDR 76 Query: 311 LQ---EAQVMKKLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQL 366 ++ E ++ ++ H +V+L YA +E +Y++ +++ G L L E + Sbjct: 77 VRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVM--FTEEDV 134 Query: 367 VDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK 426 A++A + ++ + ++RDL+ NIL+ E K+ DFGL++ D+E A Sbjct: 135 KFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFC- 193 Query: 427 FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPC 486 +++ APE T +D WSFG+L+ E+ T G +P+ G +E + + + ++ Sbjct: 194 GTVEYMAPEVVNRRGHTQSADWWSFGVLMFEMLT-GTLPFQGKDRKETMTMILKA-KLGM 251 Query: 487 PPECPESLHDLMCQCWRKEPEER----PT-FEYLQAFLEDYFTSTEP 528 P L+ +++ P R P E ++ +F++ + Sbjct: 252 PQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKR--HSFFSTIDW 296 >4CQG-A nrPDB Length = 331 Score = 248 bits (633), Expect = 4e-66, Method: Composition-based stats. Identities = 76/272 (27%), Positives = 122/272 (44%), Gaps = 12/272 (4%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPE--AFLQEAQVMKKLRHEK 324 + L +G G F +V + T VAIK + + + E +K LRH+ Sbjct: 9 KYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKTEIDALKSLRHQH 68 Query: 325 LVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 + QLY V+ ++ I++V EY G L D++ + L + + QI S +AYV Sbjct: 69 ICQLYHVLETKNKIFMVLEYCPGGELFDYIISQDR--LSEEETRVVFRQILSAVAYVHSQ 126 Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF- 442 Y HRDL+ N+L EN K+ DFGL + N+ Q + + APE + Sbjct: 127 GYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAAPELIQGKSYL 186 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCW 502 ++DVWS GILL L G +P+ + ++ RG + P S L+ Q Sbjct: 187 GSEADVWSMGILLYVLMC-GFLPFDDDNVMALYKKIMRG-KYEVPKWLSPSSILLLQQML 244 Query: 503 RKEPEERPTFEYLQAF---LEDYFTSTEPQYQ 531 + +P++R + L ++DY E Q + Sbjct: 245 QVDPKKRISMRNLLNHPWVMQDYSCPVEWQSK 276 >2BPM-A nrPDB Length = 309 Score = 248 bits (633), Expect = 4e-66, Method: Composition-based stats. Identities = 67/293 (22%), Positives = 123/293 (41%), Gaps = 39/293 (13%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMS---PEAFLQEAQVMKKL 320 + E+ + K+G+G +G V+ T V A+K ++ T + P ++E ++K+L Sbjct: 4 VDMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL 63 Query: 321 RHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 H +V+L V+ +E +Y+V E++ L F+ + LP + Q+ G+A+ Sbjct: 64 NHPNIVKLLDVIHTENKLYLVFEFL-HQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 122 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 +HRDL+ N+L+ K+ADFGLAR + + APE L Sbjct: 123 CHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAF-GVPVRTYTHEVVTLWYRAPEILLG 181 Query: 440 GR-FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER-----------------G 481 + ++ D+WS G + E+ T+ R +PG + L ++ R Sbjct: 182 CKYYSTAVDIWSLGCIFAEMVTR-RALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 240 Query: 482 YRMPCPPECPESL-----------HDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 Y+ P + L+ Q +P +R + + A +F Sbjct: 241 YKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKA--ALAHPFF 291 >3DFA-A nrPDB Length = 286 Score = 247 bits (632), Expect = 6e-66, Method: Composition-based stats. Identities = 71/258 (27%), Positives = 117/258 (45%), Gaps = 17/258 (6%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEA---FLQEAQVMKKLRHE 323 E + LG+G FGEV T + A+K + + + L+E +++KKL H Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHP 81 Query: 324 KLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +++L+ ++ + YIV E + G L D + K + Q+ SG+ Y+ + Sbjct: 82 NIMKLFEILEDSSSFYIVGELYTGGELFDEIIKR--KRFSEHDAARIIKQVFSGITYMHK 139 Query: 383 MNYVHRDLRAANILVGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 N VHRDL+ NIL+ + K+ DFGL+ + N T + + APE Sbjct: 140 HNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQN--TKMKDRIGTAYYIAPEVLR- 196 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPCPPECPESLHD 496 G + K DVWS G++L L + G P+ G ++L +VE G + +P + D Sbjct: 197 GTYDEKCDVWSAGVILYILLS-GTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKD 255 Query: 497 LMCQCWRKEPEERPTFEY 514 L+ + P R T Sbjct: 256 LIRKMLTFHPSLRITATQ 273 >3NCG-A nrPDB Length = 486 Score = 247 bits (632), Expect = 6e-66, Method: Composition-based stats. Identities = 71/258 (27%), Positives = 117/258 (45%), Gaps = 17/258 (6%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEA---FLQEAQVMKKLRHE 323 E + LG+G FGEV T + A+K + + + L+E +++KKL H Sbjct: 22 ERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTSTILREVELLKKLDHP 81 Query: 324 KLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +++L+ ++ + YIV E + G L D + K + Q+ SG+ Y+ + Sbjct: 82 NIMKLFEILEDSSSFYIVGELYTGGELFDEIIKR--KRFSEHDAARIIKQVFSGITYMHK 139 Query: 383 MNYVHRDLRAANILVGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 N VHRDL+ NIL+ + K+ DFGL+ + N T + + APE Sbjct: 140 HNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQN--TKMKDRIGTAYYIAPEVLR- 196 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPCPPECPESLHD 496 G + K DVWS G++L L + G P+ G ++L +VE G + +P + D Sbjct: 197 GTYDEKCDVWSAGVILYILLS-GTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDAKD 255 Query: 497 LMCQCWRKEPEERPTFEY 514 L+ + P R T Sbjct: 256 LIRKMLTFHPSLRITATQ 273 >2BDW-A nrPDB Length = 362 Score = 247 bits (632), Expect = 6e-66, Method: Composition-based stats. Identities = 63/285 (22%), Positives = 115/285 (40%), Gaps = 16/285 (5%) Query: 241 CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKT 299 H + + +A ++ ++ +LG+G F V T A K Sbjct: 2 PHMASMTGGQQMGRGSEFMMNASTKFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKI 61 Query: 300 LKPGTMSPEAFL---QEAQVMKKLRHEKLVQLYAVVSEEPI-YIVTEYMSKGSLLDFLKG 355 + +S F +EA++ +KL+H +V+L+ + EE Y+V + ++ G L + + Sbjct: 62 INTKKLSARDFQKLEREARICRKLQHPNIVRLHDSIQEESFHYLVFDLVTGGELFEDIVA 121 Query: 356 ETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLAR 412 ++ QI +AY VHR+L+ N+L+ K+ADFGLA Sbjct: 122 R--EFYSEADASHCIQQILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAI 179 Query: 413 LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR 472 + D+E A G + +PE ++ D+W+ G++L L G P+ Sbjct: 180 EVNDSE--AWHGFAGTPGYLSPEVLKKDPYSKPVDIWACGVILYILLV-GYPPFWDEDQH 236 Query: 473 EVLDQVERG---YRMPCPPECPESLHDLMCQCWRKEPEERPTFEY 514 + Q++ G Y P L+ P++R T + Sbjct: 237 RLYAQIKAGAYDYPSPEWDTVTPEAKSLIDSMLTVNPKKRITADQ 281 >4D2V-A nrPDB Length = 356 Score = 247 bits (631), Expect = 7e-66, Method: Composition-based stats. Identities = 76/272 (27%), Positives = 124/272 (45%), Gaps = 12/272 (4%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPE--AFLQEAQVMKKLRHEK 324 + L +G G F +V + T VAIK + T+ + E + +K LRH+ Sbjct: 29 KYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQH 88 Query: 325 LVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 + QLY V+ + I++V EY G L D++ + L + + QI S +AYV Sbjct: 89 ICQLYHVLETANKIFMVLEYCPGGELFDYIISQDR--LSEEETRVVFRQIVSAVAYVHSQ 146 Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF- 442 Y HRDL+ N+L E K+ DFGL + N+ Q + + APE + Sbjct: 147 GYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAAPELIQGKSYL 206 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCW 502 ++DVWS GILL L G +P+ ++ ++ RG + P S L+ Q Sbjct: 207 GSEADVWSMGILLYVLMC-GFLPFDDDTAAALVAKIMRG-KYDVPKWLSPSSILLLQQML 264 Query: 503 RKEPEERPTFEYLQA---FLEDYFTSTEPQYQ 531 + +P++R + + L ++DY E Q + Sbjct: 265 QVDPKKRISMKNLLNHPWIMQDYNYPVEWQSK 296 >4D28-A nrPDB Length = 446 Score = 247 bits (631), Expect = 8e-66, Method: Composition-based stats. Identities = 63/263 (23%), Positives = 115/263 (43%), Gaps = 14/263 (5%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP----EAFLQEAQVMKKLRHEK 324 + +G+G F +V T VAIK + T+ + +E +MK +RH Sbjct: 11 YEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVDQIKREISIMKIVRHPN 70 Query: 325 LVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 +V+LY V+ S+ IYIV E+++ G L D + + L+ + Q+ +A+ Sbjct: 71 IVRLYEVLASKSKIYIVLEFVTGGELFDRIVHKGR--LKEDESRKYFQQLVDAVAHCHSK 128 Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443 HRDL+ N+L+ N KV+DFGL+ L ++ P + APE + Sbjct: 129 GVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTP-NYVAPEVLSGQGYD 187 Query: 444 -IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCW 502 +D+WS G++L + G +P+ + ++ CPP + L+ + Sbjct: 188 GSAADIWSCGVILFVILA-GYLPFSETDLPGLYRKI-NAAEFDCPPWFSAEVKFLIHRIL 245 Query: 503 RKEPEERPTFEYLQAFLEDYFTS 525 P+ R + ++ + +F Sbjct: 246 DPNPKTRIQIQGIKK--DPWFRK 266 >5YKS-A nrPDB Length = 377 Score = 247 bits (630), Expect = 1e-65, Method: Composition-based stats. Identities = 62/288 (21%), Positives = 125/288 (43%), Gaps = 14/288 (4%) Query: 248 CPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTL---KPG 303 P G + L+ LG+G F V + T +VA+K + K Sbjct: 15 VLFQGPHMAGFKRGYDGKIAGLYDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLD 74 Query: 304 TMSPEAFLQEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLR 362 T++ QE + MK ++H +V+LY V+ ++ +Y++ E G + D++ + L Sbjct: 75 TLATGHLFQEVRCMKLVQHPNIVRLYEVIDTQTKLYLILELGDGGDMFDYIMKHE-EGLN 133 Query: 363 LPQLVDMAAQIASGMAYVERMNYVHRDLRAAN-ILVGENLVCKVADFGLARLIEDNEYTA 421 AQI ++Y +++ VHRDL+ N + + + K+ DFG + + + Sbjct: 134 EDLAKKYFAQIVHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGK--K 191 Query: 422 RQGAKFPIKWTAPEAALYGRFT-IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER 480 + + ++APE L + D+WS G++L + G+ P+ + E L + Sbjct: 192 LTTSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILF-MLVCGQPPFQEANDSETLTMIMD 250 Query: 481 GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEP 528 + P + DL+ + +++P+ R + E ++ + +P Sbjct: 251 -CKYTVPSHVSKECKDLITRMLQRDPKRRASLEEIEN--HPWLQGVDP 295 >3KK8-A nrPDB Length = 284 Score = 247 bits (630), Expect = 1e-65, Method: Composition-based stats. Identities = 61/258 (23%), Positives = 110/258 (42%), Gaps = 16/258 (6%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSPEAFL---QEAQVMKKLRHE 323 ++ ++ +LG+G F V T A K + +S F +EA++ +KL+H Sbjct: 6 DNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKLQHP 65 Query: 324 KLVQLYAVVSEEPI-YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V+L+ + EE Y+V + ++ G L + + ++ QI +AY Sbjct: 66 NIVRLHDSIQEESFHYLVFDLVTGGELFEDIVAR--EFYSEADASHCIQQILESIAYCHS 123 Query: 383 MNYVHRDLRAANILVGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 VHR+L+ N+L+ K+ADFGLA + D+E A G + +PE Sbjct: 124 NGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSE--AWHGFAGTPGYLSPEVLKK 181 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPCPPECPESLHD 496 ++ D+W+ G++L L G P+ + Q++ G Y P Sbjct: 182 DPYSKPVDIWACGVILYILLV-GYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTPEAKS 240 Query: 497 LMCQCWRKEPEERPTFEY 514 L+ P++R T + Sbjct: 241 LIDSMLTVNPKKRITADQ 258 >2Z7Q-A nrPDB Length = 321 Score = 246 bits (627), Expect = 2e-65, Method: Composition-based stats. Identities = 62/263 (23%), Positives = 121/263 (46%), Gaps = 13/263 (4%) Query: 255 TQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTW----NGTTRVAIKTLKPGTMSPEAF 310 T + + + L LGQG FG+V++ + A+K LK T+ Sbjct: 15 THHVKAGSEKADPSHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRDR 74 Query: 311 LQ---EAQVMKKLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQL 366 ++ E ++ + H +V+L YA +E +Y++ +++ G L L E + Sbjct: 75 VRTKMERDILADVNHPFVVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVM--FTEEDV 132 Query: 367 VDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK 426 A++A G+ ++ + ++RDL+ NIL+ E K+ DFGL++ D+E A Sbjct: 133 KFYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFC- 191 Query: 427 FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPC 486 +++ APE + +D WS+G+L+ E+ T G +P+ G +E + + + ++ Sbjct: 192 GTVEYMAPEVVNRQGHSHSADWWSYGVLMFEMLT-GSLPFQGKDRKETMTLILKA-KLGM 249 Query: 487 PPECPESLHDLMCQCWRKEPEER 509 P L+ +++ P R Sbjct: 250 PQFLSTEAQSLLRALFKRNPANR 272 >6FDY-U nrPDB Length = 276 Score = 245 bits (626), Expect = 3e-65, Method: Composition-based stats. Identities = 67/265 (25%), Positives = 119/265 (44%), Gaps = 16/265 (6%) Query: 261 DAWEIPRES-LRLEVKLGQGCFGEVWMGTWNGTTR--VAIKTLKPGTMSP---EAFLQEA 314 W PR L +LG G + V+ TR VAIK + +++ E L E Sbjct: 3 PGWGPPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEI 62 Query: 315 QVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373 +++K +RH +VQL + + IY++ E+ + G L F+ + L Q+ Sbjct: 63 EILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTR--RILPEKVARVFMQQL 120 Query: 374 ASGMAYVERMNYVHRDLRAANILVG--ENLVCKVADFGLARLIEDNEYTARQGAKFPIKW 431 AS + ++ N H DL+ NIL+ E K+ADFG A+ + + + + + Sbjct: 121 ASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSP--WDEKHVLRGSPLY 178 Query: 432 TAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE--RGYRMPCPPE 489 APE ++ + D+WS G++L E G+ P+ E+ +++ R +P P Sbjct: 179 MAPEMVCQRQYDARVDLWSMGVILYE-ALFGQPPFASRSFSELEEKIRSNRVIELPLRPL 237 Query: 490 CPESLHDLMCQCWRKEPEERPTFEY 514 DL+ + ++P R +F+ Sbjct: 238 LSRDCRDLLQRLLERDPSRRISFQD 262 >2V7O-A nrPDB Length = 336 Score = 245 bits (625), Expect = 4e-65, Method: Composition-based stats. Identities = 62/258 (24%), Positives = 111/258 (43%), Gaps = 15/258 (5%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTL---KPGTMSPEAFLQEAQVMKKLRHE 323 + +L +LG+G F V T A K + K + +EA++ + L+H Sbjct: 31 DDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 90 Query: 324 KLVQLYAVVSEEPI-YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V+L+ +SEE Y+V + ++ G L + + +Y QI + ++ + Sbjct: 91 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIHQILESVNHIHQ 148 Query: 383 MNYVHRDLRAANILVGENL---VCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 + VHRDL+ N+L+ K+ADFGLA ++ E A G + +PE Sbjct: 149 HDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQ-GEQQAWFGFAGTPGYLSPEVLRK 207 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMPCPPE--CPESLHD 496 + D+W+ G++L L G P+ ++ Q++ G Y P P + Sbjct: 208 DPYGKPVDIWACGVILYILLV-GYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKN 266 Query: 497 LMCQCWRKEPEERPTFEY 514 L+ Q P +R T + Sbjct: 267 LINQMLTINPAKRITADQ 284 >4FZF-B nrPDB Length = 283 Score = 245 bits (625), Expect = 4e-65, Method: Composition-based stats. Identities = 74/257 (28%), Positives = 114/257 (44%), Gaps = 9/257 (3%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLK--PGTMSPEAFLQEAQVMKKLRH 322 P E ++G+G FGEV+ G N T +V AIK + E QE V+ + Sbjct: 6 PEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS 65 Query: 323 EKLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 + + Y + ++I+ EY+ GS LD L+ Q+ M +I G+ Y+ Sbjct: 66 SYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRA---GPFDEFQIATMLKEILKGLDYLH 122 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 +HRD++AAN+L+ E K+A FG+A + D + P W APE Sbjct: 123 SEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPF-WMAPEVIQQSA 181 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 501 + K+D+WS GI EL KG P M VL + + + +S + + C Sbjct: 182 YDSKADIWSLGITAIELA-KGEPPNSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDAC 240 Query: 502 WRKEPEERPTFEYLQAF 518 K+P RPT + L Sbjct: 241 LNKDPSFRPTAKELLKH 257 >4UZD-A nrPDB Length = 287 Score = 245 bits (625), Expect = 4e-65, Method: Composition-based stats. Identities = 57/274 (20%), Positives = 111/274 (40%), Gaps = 15/274 (5%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPE----AFLQEAQVMKKLRH 322 E + LG+G FG V++ + + A+K L + +E ++ LRH Sbjct: 8 EDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRH 67 Query: 323 EKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 +++LY + +Y++ EY G++ L+ + + ++A+ ++Y Sbjct: 68 PNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLS--KFDEQRTATYITELANALSYCH 125 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 +HRD++ N+L+G K+ADFG + + R + + PE Sbjct: 126 SKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPS---SRRTTLCGTLDYLPPEMIEGRM 182 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 501 K D+WS G+L E G+ P+ +E ++ R P E DL+ + Sbjct: 183 HDEKVDLWSLGVLCYEFLV-GKPPFEANTYQETYKRISR-VEFTFPDFVTEGARDLISRL 240 Query: 502 WRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGEN 535 + P +RP + + T+ + +N Sbjct: 241 LKHNPSQRPMLREVLE--HPWITANSSKPSNCQN 272 >2XIK-A nrPDB Length = 294 Score = 245 bits (625), Expect = 4e-65, Method: Composition-based stats. Identities = 75/267 (28%), Positives = 117/267 (43%), Gaps = 11/267 (4%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLK--PGTMSPEAFLQEAQVMKKLRH 322 P E ++G+G FGEV+ G N T V AIK + E QE V+ + Sbjct: 17 PEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDS 76 Query: 323 EKLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 + + + + ++I+ EY+ GS LD LK L + + +I G+ Y+ Sbjct: 77 PYITRYFGSYLKSTKLWIIMEYLGGGSALDLLK---PGPLEETYIATILREILKGLDYLH 133 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 +HRD++AAN+L+ E K+ADFG+A + D + P W APE Sbjct: 134 SERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPF-WMAPEVIKQSA 192 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 501 + K+D+WS GI EL KG P + VL + + + + + + C Sbjct: 193 YDFKADIWSLGITAIELA-KGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEAC 251 Query: 502 WRKEPEERPTFEYL--QAFLEDYFTST 526 K+P RPT + L F+ Y T Sbjct: 252 LNKDPRFRPTAKELLKHKFITRYTKKT 278 >2JC6-A nrPDB Length = 334 Score = 244 bits (623), Expect = 7e-65, Method: Composition-based stats. Identities = 62/278 (22%), Positives = 118/278 (42%), Gaps = 19/278 (6%) Query: 251 SKPQTQGLAKDAWEIPRES----LRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTM 305 S + G + +W+ E + LG G F EV + T ++ A+K + + Sbjct: 1 SMARENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKAL 60 Query: 306 SPEA--FLQEAQVMKKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLR 362 + E V++K++HE +V L + +Y+V + +S G L D + + + Sbjct: 61 KGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKG--FYT 118 Query: 363 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILV---GENLVCKVADFGLARLIEDNEY 419 + Q+ + Y+ RM VHRDL+ N+L E ++DFGL+++ + + Sbjct: 119 EKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKM--EGKG 176 Query: 420 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE 479 A + APE ++ D WS G++ L G P+ + ++ +Q+ Sbjct: 177 DVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLC-GYPPFYDENDSKLFEQIL 235 Query: 480 RG---YRMPCPPECPESLHDLMCQCWRKEPEERPTFEY 514 + + P + +S D + K+P +R T E Sbjct: 236 KAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQ 273 >5FG8-A nrPDB Length = 285 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 59/272 (21%), Positives = 110/272 (40%), Gaps = 17/272 (6%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSPEAFL---QEAQVMKKLRHE 323 ++ ++ +LG+G F V T A K + ++ F +EA++ +KL H Sbjct: 14 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHP 73 Query: 324 KLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V+L+ + E Y+V + ++ G L + + ++ QI + + + Sbjct: 74 NIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAR--EFYSEADASHCIQQILESVNHCHQ 131 Query: 383 MNYVHRDLRAANILVGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 VHRDL+ N+L+ K+ADFGLA ++ + + A G + +PE Sbjct: 132 NGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGD-HQAWFGFAGTPGYLSPEVLKK 190 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPCPPECPESLHD 496 + D+W+ G++L L G P+ + Q++ G Y P + Sbjct: 191 EPYGKSVDIWACGVILYILLV-GYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKN 249 Query: 497 LMCQCWRKEPEERPTFEYLQAFLEDYFTSTEP 528 L+ Q P +R T A + E Sbjct: 250 LINQMLTVNPNKRITAAE--ALKHPWICQRER 279 >5KCV-A nrPDB Length = 460 Score = 242 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 65/311 (20%), Positives = 126/311 (40%), Gaps = 21/311 (6%) Query: 234 SKHADGLCHRLTTVCPTSKPQTQGLA--KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNG 291 + A + R + S + ++ K + LG+G FG+V + Sbjct: 126 KQAAAEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKA 185 Query: 292 TTRV-AIKTLKPGTMSPEA----FLQEAQVMKKLRHEKLVQL-YAVVSEEPIYIVTEYMS 345 T R A+K LK + + L E +V++ RH L L Y+ + + + V EY + Sbjct: 186 TGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYAN 245 Query: 346 KGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER-MNYVHRDLRAANILVGENLVCK 404 G L L E + + A+I S + Y+ N V+RDL+ N+++ ++ K Sbjct: 246 GGELFFHLSRE--RVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIK 303 Query: 405 VADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRV 464 + DFGL + + T + P ++ APE + D W G+++ E+ GR+ Sbjct: 304 ITDFGLCKEGIKDGATMKTFCGTP-EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMC-GRL 361 Query: 465 PYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERP-----TFEYLQAFL 519 P+ + ++ + + + P L+ +K+P++R + + Sbjct: 362 PFYNQDHEKLFELILM-EEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQ-- 418 Query: 520 EDYFTSTEPQY 530 +F Q+ Sbjct: 419 HRFFAGIVWQH 429 >4YNZ-A nrPDB Length = 342 Score = 242 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 69/256 (26%), Positives = 122/256 (47%), Gaps = 12/256 (4%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFL---QEAQVMKKLRHEKL 325 RLE LG+G G V +G T +VAIK + +S + +E ++K + H + Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHV 71 Query: 326 VQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN 384 ++L+ V + +Y+V E++S G L D+L + L + QI S + + + Sbjct: 72 LKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGR--LTPKEARKFFRQIISALDFCHSHS 129 Query: 385 YVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT- 443 HRDL+ N+L+ E ++ADFG+A L + + + + + PE ++ Sbjct: 130 ICHRDLKPENLLLDERNNIRIADFGMASLQVGD--SLLETSCGSPHYACPEVIRGEKYDG 187 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWR 503 K+DVWS G++L L G +P+ R++L++V+RG P P L+ Sbjct: 188 RKADVWSCGVILFALLV-GALPFDDDNLRQLLEKVKRGV-FHMPHFIPPDCQSLLRGMIE 245 Query: 504 KEPEERPTFEYLQAFL 519 + R T E++Q + Sbjct: 246 VDAARRLTLEHIQKHI 261 >2JDO-A nrPDB Length = 342 Score = 242 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 60/278 (21%), Positives = 119/278 (42%), Gaps = 18/278 (6%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEA----FLQEAQVM 317 ++ LG+G FG+V + T R A+K L+ + + + E++V+ Sbjct: 5 PKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVL 64 Query: 318 KKLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 + RH L L YA + + + V EY + G L L E + + A+I S Sbjct: 65 QNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRE--RVFTEERARFYGAEIVSA 122 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 + Y+ + V+RD++ N+++ ++ K+ DFGL + + T + P ++ APE Sbjct: 123 LEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTP-EYLAPEV 181 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 + D W G+++ E+ GR+P+ + + + + + P Sbjct: 182 LEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHERLFELILM-EEIRFPRTLSPEAKS 239 Query: 497 LMCQCWRKEPEER----PT-FEYLQAFLEDYFTSTEPQ 529 L+ +K+P++R P+ + + +F S Q Sbjct: 240 LLAGLLKKDPKQRLGGGPSDAKEVME--HRFFLSINWQ 275 >5D7A-A nrPDB Length = 308 Score = 242 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 66/273 (24%), Positives = 112/273 (41%), Gaps = 19/273 (6%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTRVA-IKTLKPGTMSPEAFLQEAQVMKKLRHE- 323 P L +G G +G+V+ G T ++A IK + E QE ++KK H Sbjct: 15 PAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHR 74 Query: 324 KLVQLYAVV-------SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 + Y ++ +++V E+ GS+ D +K G L+ + + +I G Sbjct: 75 NIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRG 134 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 ++++ + +HRD++ N+L+ EN K+ DFG++ + D R W APE Sbjct: 135 LSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQL-DRTVGRRNTFIGTPYWMAPEV 193 Query: 437 ALYGR-----FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPC-PPEC 490 + KSD+WS GI E+ +G P M L + R + Sbjct: 194 IACDENPDATYDFKSDLWSLGITAIEMA-EGAPPLCDMHPMRALFLIPRNPAPRLKSKKW 252 Query: 491 PESLHDLMCQCWRKEPEERPTFEYL--QAFLED 521 + + C K +RP E L F+ D Sbjct: 253 SKKFQSFIESCLVKNHSQRPATEQLMKHPFIRD 285 >3NIZ-A nrPDB Length = 311 Score = 242 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 69/297 (23%), Positives = 124/297 (41%), Gaps = 40/297 (13%) Query: 267 RESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMS---PEAFLQEAQVMKKLRHE 323 E + K+G+G +G V+ + VA+K ++ P ++E ++K+L H Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKDSQGRIVALKRIRLDAEDEGIPSTAIREISLLKELHHP 79 Query: 324 KLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V L V+ E + +V E+M K L L E L+ Q+ Q+ G+A+ + Sbjct: 80 NIVSLIDVIHSERCLTLVFEFMEK-DLKKVL-DENKTGLQDSQIKIYLYQLLRGVAHCHQ 137 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY-GR 441 +HRDL+ N+L+ + K+ADFGLAR + + + AP+ + + Sbjct: 138 HRILHRDLKPQNLLINSDGALKLADFGLARAF-GIPVRSYTHEVVTLWYRAPDVLMGSKK 196 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP---------- 491 ++ D+WS G + E+ T G+ +PG+ + + L ++ P P E P Sbjct: 197 YSTSVDIWSIGCIFAEMIT-GKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQ 255 Query: 492 -------------------ESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 + DL+ +P +R + A YF +PQ Sbjct: 256 RTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARD--AMNHPYFKDLDPQ 310 >4HVI-A nrPDB Length = 314 Score = 242 bits (618), Expect = 3e-64, Method: Composition-based stats. Identities = 96/281 (34%), Positives = 143/281 (50%), Gaps = 26/281 (9%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGT-----WNGTTRVAIKTLK-PGTMSPEAFLQEAQVMK 318 L+ +LG+G FG V + N VA+K L+ G F +E Q++K Sbjct: 7 FEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILK 66 Query: 319 KLRHEKLVQLYAV---VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIAS 375 L + +V+ V + + +V EY+ G L DFL+ + L +L+ ++QI Sbjct: 67 ALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRAR-LDASRLLLYSSQICK 125 Query: 376 GMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTA 433 GM Y+ VHRDL A NILV K+ADFGLA+L ++ + Y R+ + PI W A Sbjct: 126 GMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYA 185 Query: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGR---VP---YPGMVNRE--------VLDQVE 479 PE+ F+ +SDVWSFG++L EL T P + M+ E +L+ +E Sbjct: 186 PESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLE 245 Query: 480 RGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 G R+P PP CP +H+LM CW P++RP+F L L+ Sbjct: 246 EGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLD 286 >4JXF-A nrPDB Length = 266 Score = 242 bits (618), Expect = 3e-64, Method: Composition-based stats. Identities = 70/267 (26%), Positives = 114/267 (42%), Gaps = 13/267 (4%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSP----EAFLQEAQVMKKLRH 322 E ++ LG+G F V+ T VAIK + M + E ++ +L+H Sbjct: 7 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKH 66 Query: 323 EKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 +++LY + +Y+V E G + +LK K + QI +GM Y+ Sbjct: 67 PSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRV-KPFSENEARHFMHQIITGMLYLH 125 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 +HRDL +N+L+ N+ K+ADFGLA ++ P + +PE A Sbjct: 126 SHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTP-NYISPEIATRSA 184 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 501 ++SDVWS G + L GR P+ + L++V P DL+ Q Sbjct: 185 HGLESDVWSLGCMFYTLL-IGRPPFDTDTVKNTLNKVVLA-DYEMPSFLSIEAKDLIHQL 242 Query: 502 WRKEPEERPTFEYLQAFLEDYFTSTEP 528 R+ P +R + L + L+ F S Sbjct: 243 LRRNPADRLS---LSSVLDHPFMSRNS 266 >2VN9-A nrPDB Length = 301 Score = 242 bits (618), Expect = 3e-64, Method: Composition-based stats. Identities = 60/258 (23%), Positives = 108/258 (41%), Gaps = 15/258 (5%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTL---KPGTMSPEAFLQEAQVMKKLRHE 323 + +L +LG+G F V T + A K + K + +EA++ + L+H Sbjct: 4 DEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 63 Query: 324 KLVQLYAVVSEEPI-YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V+L+ +SEE Y+V + ++ G L + + +Y QI + + Sbjct: 64 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIQQILESVNHCHL 121 Query: 383 MNYVHRDLRAANILV---GENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 VHRDL+ N+L+ + K+ADFGLA ++ ++ G + +PE Sbjct: 122 NGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWF-GFAGTPGYLSPEVLRK 180 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMPCPPE--CPESLHD 496 + D+W+ G++L L G P+ + Q++ G Y P P D Sbjct: 181 DPYGKPVDMWACGVILYILLV-GYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 239 Query: 497 LMCQCWRKEPEERPTFEY 514 L+ + P +R T Sbjct: 240 LINKMLTINPAKRITASE 257 >4FG9-A nrPDB Length = 320 Score = 242 bits (618), Expect = 3e-64, Method: Composition-based stats. Identities = 60/267 (22%), Positives = 115/267 (43%), Gaps = 17/267 (6%) Query: 267 RESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEA--FLQEAQVMKKLRHE 323 R+ LG G F EV + T + VAIK + + + E V+ K++H Sbjct: 17 RDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHP 76 Query: 324 KLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V L + +Y++ + +S G L D + + + + Q+ + Y+ Sbjct: 77 NIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKG--FYTERDASRLIFQVLDAVKYLHD 134 Query: 383 MNYVHRDLRAANIL---VGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 + VHRDL+ N+L + E+ ++DFGL+++ ++ + A + APE Sbjct: 135 LGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKM--EDPGSVLSTACGTPGYVAPEVLAQ 192 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPCPPECPESLHD 496 ++ D WS G++ L G P+ + ++ +Q+ + + P + +S D Sbjct: 193 KPYSKAVDCWSIGVIAYILLC-GYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKD 251 Query: 497 LMCQCWRKEPEERPTFEYLQAFLEDYF 523 + K+PE+R T E QA + Sbjct: 252 FIRHLMEKDPEKRFTCE--QALQHPWI 276 >2VZ6-A nrPDB Length = 313 Score = 241 bits (615), Expect = 6e-64, Method: Composition-based stats. Identities = 62/266 (23%), Positives = 109/266 (40%), Gaps = 17/266 (6%) Query: 270 LRLEVKLGQGCFGEVWMG-TWNGTTRVAIKTL---KPGTMSPEAFLQEAQVMKKLRHEKL 325 +L +LG+G F V A K + K + +EA++ + L+H + Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 83 Query: 326 VQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN 384 V+L+ +SEE Y++ + ++ G L + + +Y QI + + +M Sbjct: 84 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAR--EYYSEADASHCIQQILEAVLHCHQMG 141 Query: 385 YVHRDLRAANILVGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 VHRDL+ N+L+ K+ADFGLA + + E A G + +PE Sbjct: 142 VVHRDLKPENLLLASKLKGAAVKLADFGLAIEV-EGEQQAWFGFAGTPGYLSPEVLRKDP 200 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMPCPPE--CPESLHDLM 498 + D+W+ G++L L G P+ + Q++ G Y P P DL+ Sbjct: 201 YGKPVDLWACGVILYILLV-GYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 259 Query: 499 CQCWRKEPEERPTFEYLQAFLEDYFT 524 + P +R T A + + Sbjct: 260 NKMLTINPSKRITAAE--ALKHPWIS 283 >2JAM-A nrPDB Length = 304 Score = 241 bits (615), Expect = 6e-64, Method: Composition-based stats. Identities = 66/257 (25%), Positives = 114/257 (44%), Gaps = 15/257 (5%) Query: 267 RESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEAFLQ-EAQVMKKLRHEK 324 R++ LG G F EV++ T ++ A+K +K ++ L+ E V+KK++HE Sbjct: 8 RKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHEN 67 Query: 325 LVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 +V L + Y+V + +S G L D + + Q+ S + Y+ Sbjct: 68 IVTLEDIYESTTHYYLVMQLVSGGELFDRILERG--VYTEKDASLVIQQVLSAVKYLHEN 125 Query: 384 NYVHRDLRAANILV---GENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 440 VHRDL+ N+L EN + DFGL+++ ++ + A + APE Sbjct: 126 GIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMST---ACGTPGYVAPEVLAQK 182 Query: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY---RMPCPPECPESLHDL 497 ++ D WS G++ L G P+ ++ ++++ GY P + ES D Sbjct: 183 PYSKAVDCWSIGVITYILLC-GYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDF 241 Query: 498 MCQCWRKEPEERPTFEY 514 +C K+P ER T E Sbjct: 242 ICHLLEKDPNERYTCEK 258 >5U6Y-A nrPDB Length = 461 Score = 241 bits (615), Expect = 6e-64, Method: Composition-based stats. Identities = 62/266 (23%), Positives = 109/266 (40%), Gaps = 17/266 (6%) Query: 270 LRLEVKLGQGCFGEVWMG-TWNGTTRVAIKTL---KPGTMSPEAFLQEAQVMKKLRHEKL 325 +L +LG+G F V A K + K + +EA++ + L+H + Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNI 61 Query: 326 VQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN 384 V+L+ +SEE Y++ + ++ G L + + +Y QI + + +M Sbjct: 62 VRLHDSISEEGHHYLIFDLVTGGELFEDIVAR--EYYSEADASHCIQQILEAVLHCHQMG 119 Query: 385 YVHRDLRAANILVGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 VHRDL+ N+L+ K+ADFGLA + + E A G + +PE Sbjct: 120 VVHRDLKPENLLLASKLKGAAVKLADFGLAIEV-EGEQQAWFGFAGTPGYLSPEVLRKDP 178 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMPCPPE--CPESLHDLM 498 + D+W+ G++L L G P+ + Q++ G Y P P DL+ Sbjct: 179 YGKPVDLWACGVILYILLV-GYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLI 237 Query: 499 CQCWRKEPEERPTFEYLQAFLEDYFT 524 + P +R T A + + Sbjct: 238 NKMLTINPSKRITAAE--ALKHPWIS 261 >3DAK-A nrPDB Length = 290 Score = 239 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 73/293 (24%), Positives = 125/293 (42%), Gaps = 27/293 (9%) Query: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLK--PGTMSPEAFLQEAQ 315 + W I R+ L+ +G G V +VAIK + S + L+E Q Sbjct: 1 SALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQ 60 Query: 316 VMKKLRHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKG------ETGKYLRLPQLVD 368 M + H +V Y + V ++ +++V + +S GS+LD +K L + Sbjct: 61 AMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIAT 120 Query: 369 MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED----NEYTARQG 424 + ++ G+ Y+ + +HRD++A NIL+GE+ ++ADFG++ + R+ Sbjct: 121 ILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKT 180 Query: 425 AKFPIKWTAPEAALY-GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 483 W APE + K+D+WSFGI EL T G PY +VL + Sbjct: 181 FVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELAT-GAAPYHKYPPMKVLMLTLQNDP 239 Query: 484 MPCP---------PECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE 527 + +S ++ C +K+PE+RPT L +F + Sbjct: 240 PSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAEL--LRHKFFQKAK 290 >1FOT-A nrPDB Length = 318 Score = 239 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 57/248 (22%), Positives = 109/248 (43%), Gaps = 14/248 (5%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTM----SPEAFLQEAQVMKKLRH 322 + ++ LG G FG V + R A+K LK + E E ++ + H Sbjct: 6 QDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTH 65 Query: 323 EKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 +++++ + + I+++ +Y+ G L L+ + P AA++ + Y+ Sbjct: 66 PFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRK--SQRFPNPVAKFYAAEVCLALEYLH 123 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 + ++RDL+ NIL+ +N K+ DFG A+ + D YT + APE Sbjct: 124 SKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTL----CGTPDYIAPEVVSTKP 179 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 501 + D WSFGIL+ E+ G P+ + +++ + PP E + DL+ + Sbjct: 180 YNKSIDWWSFGILIYEMLA-GYTPFYDSNTMKTYEKILNA-ELRFPPFFNEDVKDLLSRL 237 Query: 502 WRKEPEER 509 ++ +R Sbjct: 238 ITRDLSQR 245 >3D2K-A nrPDB Length = 272 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 57/277 (20%), Positives = 111/277 (40%), Gaps = 17/277 (6%) Query: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPE----AFLQE 313 +K W + E + LG+G FG V++ + + A+K L + +E Sbjct: 5 SKRQWTL--EDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAGVEHQLRRE 62 Query: 314 AQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQ 372 ++ LRH +++LY + +Y++ EY G++ L+ + + + Sbjct: 63 VEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSR--FDEQRTATYITE 120 Query: 373 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT 432 +A+ ++Y +HRD++ N+L+G N K+ADFG + + R + + Sbjct: 121 LANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWSVHAPS---SRRTTLCGTLDYL 177 Query: 433 APEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE 492 PE K D+WS G+L E G P+ +E ++ R P E Sbjct: 178 PPEMIEGRMHDEKVDLWSLGVLCYEFLV-GMPPFEAHTYQETYRRISR-VEFTFPDFVTE 235 Query: 493 SLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 DL+ + + +R T + + + + Sbjct: 236 GARDLISRLLKHNASQRLTLAEVLE--HPWIKANSSK 270 >2HAK-A nrPDB Length = 328 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 66/226 (29%), Positives = 116/226 (51%), Gaps = 12/226 (5%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP---EAFLQEAQVMKKLRHE 323 + RL+ +G+G F +V + T R VA+K + ++P + +E ++MK L H Sbjct: 15 GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHP 74 Query: 324 KLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V+L+ V+ +E+ +Y+V EY S G + D+L ++ + QI S + Y + Sbjct: 75 NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR--MKEKEARAKFRQIVSAVQYCHQ 132 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 VHRDL+A N+L+ ++ K+ADFG + + APE ++ Sbjct: 133 KYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVG--NKLDTFCGSPPYAAPELFQGKKY 190 Query: 443 T-IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMPC 486 + DVWS G++L L + G +P+ G +E+ ++V RG YR+P Sbjct: 191 DGPEVDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGKYRIPF 235 >3LMG-A nrPDB Length = 344 Score = 238 bits (607), Expect = 5e-63, Method: Composition-based stats. Identities = 95/274 (34%), Positives = 137/274 (50%), Gaps = 10/274 (3%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNGTTR-----VAIKTL--KPGTMSPEAFLQEAQVM 317 LR LG G FG V G W V IK + K G S +A + Sbjct: 28 FKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAI 87 Query: 318 KKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 L H +V+L + + +VT+Y+ GSLLD ++ G L L++ QIA GM Sbjct: 88 GSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRG-ALGPQLLLNWGVQIAKGM 146 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEA 436 Y+E VHR+L A N+L+ +VADFG+A L+ D++ AK PIKW A E+ Sbjct: 147 YYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALES 206 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 +G++T +SDVWS+G+ + EL T G PY G+ EV D +E+G R+ P C ++ Sbjct: 207 IHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYM 266 Query: 497 LMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 +M +CW + RPTF+ L P+Y Sbjct: 267 VMVKCWMIDENIRPTFKELANEFTRM-ARDPPRY 299 >4APC-A nrPDB Length = 350 Score = 237 bits (606), Expect = 7e-63, Method: Composition-based stats. Identities = 59/250 (23%), Positives = 110/250 (44%), Gaps = 7/250 (2%) Query: 273 EVKLGQGCFGEVWMGTWN-GTTRVAIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQL 328 K+G+G FG+ + + IK + MS E +E V+ ++H +VQ Sbjct: 29 LQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQY 88 Query: 329 YAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 E +YIV +Y G L + + G + Q++D QI + +V +H Sbjct: 89 RESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILH 148 Query: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 447 RD+++ NI + ++ ++ DFG+AR++ AR + +PE + KSD Sbjct: 149 RDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELAR-ACIGTPYYLSPEICENKPYNNKSD 207 Query: 448 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPE 507 +W+ G +L EL T + + ++ ++ G P L L+ Q +++ P Sbjct: 208 IWALGCVLYELCTLKHA-FEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPR 266 Query: 508 ERPTFEYLQA 517 +RP+ + Sbjct: 267 DRPSVNSILE 276 >3MV5-A nrPDB Length = 342 Score = 237 bits (606), Expect = 7e-63, Method: Composition-based stats. Identities = 61/280 (21%), Positives = 116/280 (41%), Gaps = 19/280 (6%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEA----FLQEAQVM 317 + LG+G FG+V + T R A+K LK + + L E +V+ Sbjct: 5 PRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVL 64 Query: 318 KKLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 + RH L L Y+ + + + V EY + G L L E + + A+I S Sbjct: 65 QNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRE--RVFSEDRARFYGAEIVSA 122 Query: 377 MAYVER-MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPE 435 + Y+ N V+RDL+ N+++ ++ K+ DFGL + + T + P ++ APE Sbjct: 123 LDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTP-EYLAPE 181 Query: 436 AALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLH 495 + D W G+++ E+ GR+P+ + ++ + + + P Sbjct: 182 VLEDNDYGRAVDWWGLGVVMYEMMC-GRLPFYNQDHEKLFELILM-EEIRFPRTLGPEAK 239 Query: 496 DLMCQCWRKEPEERP-----TFEYLQAFLEDYFTSTEPQY 530 L+ +K+P++R + + +F Q+ Sbjct: 240 SLLSGLLKKDPKQRLGGGSEDAKEIMQ--HRFFAGIVWQH 277 >6C9D-A nrPDB Length = 459 Score = 237 bits (605), Expect = 9e-63, Method: Composition-based stats. Identities = 67/226 (29%), Positives = 117/226 (51%), Gaps = 12/226 (5%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP---EAFLQEAQVMKKLRHE 323 + RL+ +G+G F +V + T R VA+K + ++P + +E ++MK L H Sbjct: 21 GNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHP 80 Query: 324 KLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V+L+ V+ +E+ +Y+V EY S G + D+L ++ + QI S + Y + Sbjct: 81 NIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGR--MKEKEARAKFRQIVSAVQYCHQ 138 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 VHRDL+A N+L+ ++ K+ADFG + P + APE ++ Sbjct: 139 KYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPP--YAAPELFQGKKY 196 Query: 443 T-IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMPC 486 + DVWS G++L L + G +P+ G +E+ ++V RG YR+P Sbjct: 197 DGPEVDVWSLGVILYTLVS-GSLPFDGQNLKELRERVLRGKYRIPF 241 >3BHH-A nrPDB Length = 295 Score = 237 bits (605), Expect = 9e-63, Method: Composition-based stats. Identities = 59/258 (22%), Positives = 107/258 (41%), Gaps = 15/258 (5%) Query: 268 ESLRLEVKLGQGCFGEVWMG-TWNGTTRVAIKTL---KPGTMSPEAFLQEAQVMKKLRHE 323 + +L +G+G F V A K + K + +EA++ + L+H Sbjct: 4 DEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHS 63 Query: 324 KLVQLYAVVSEEPI-YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V+L+ +SEE Y+V + ++ G L + + +Y QI + + + Sbjct: 64 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAR--EYYSEADASHCIQQILEAVLHCHQ 121 Query: 383 MNYVHRDLRAANILVGENL---VCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 M VHRDL+ N+L+ K+ADFGLA ++ ++ G + +PE Sbjct: 122 MGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWF-GFAGTPGYLSPEVLRK 180 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMPCPPE--CPESLHD 496 + D+W+ G++L L G P+ ++ Q++ G Y P P + Sbjct: 181 EAYGKPVDIWACGVILYILLV-GYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKN 239 Query: 497 LMCQCWRKEPEERPTFEY 514 L+ Q P +R T Sbjct: 240 LINQMLTINPAKRITAHE 257 >4I6B-A nrPDB Length = 308 Score = 237 bits (605), Expect = 9e-63, Method: Composition-based stats. Identities = 72/258 (27%), Positives = 116/258 (44%), Gaps = 13/258 (5%) Query: 273 EVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSP----EAFLQEAQVMKKLRHEKLVQ 327 LG+G F + + T +V A K + +S E +E ++ + L H+ +VQ Sbjct: 33 GKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQREKIDKEIELHRILHHKHVVQ 92 Query: 328 LYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 Y + E IYI+ EY S+ S+ LK K L P++ QI SG+ Y+ + Sbjct: 93 FYHYFEDKENIYILLEYCSRRSMAHILKAR--KVLTEPEVRYYLRQIVSGLKYLHEQEIL 150 Query: 387 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 446 HRDL+ N + E++ KV DFGLA +E E+ R P + +PE +S Sbjct: 151 HRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTP-NYLSPEVLNKQGHGAES 209 Query: 447 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEP 506 D+W+ G ++ + GR P+ +E + R P L+ K P Sbjct: 210 DIWALGCVMYTML-LGRPPFETTNLKETYRSIREA-RYTMPSSLLAPAKHLIASMLSKNP 267 Query: 507 EERPTFEYLQAFLEDYFT 524 E+RP+ + + D+FT Sbjct: 268 EDRPSLDDI--IRHDFFT 283 >4L42-A nrPDB Length = 346 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 58/263 (22%), Positives = 116/263 (44%), Gaps = 15/263 (5%) Query: 257 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTW---NGTTRV-AIKTLKP-----GTMSP 307 + + +I E L LG+G +G+V+ T ++ A+K LK Sbjct: 7 SVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDT 66 Query: 308 EAFLQEAQVMKKLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQL 366 E ++++++H +V L YA + +Y++ EY+S G L F++ E Sbjct: 67 AHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL--FMQLEREGIFMEDTA 124 Query: 367 VDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK 426 A+I+ + ++ + ++RDL+ NI++ K+ DFGL + + Sbjct: 125 CFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFC- 183 Query: 427 FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPC 486 I++ APE + D WS G L+ ++ T G P+ G ++ +D++ + ++ Sbjct: 184 GTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLT-GAPPFTGENRKKTIDKILK-CKLNL 241 Query: 487 PPECPESLHDLMCQCWRKEPEER 509 PP + DL+ + ++ R Sbjct: 242 PPYLTQEARDLLKKLLKRNAASR 264 >6HXF-B nrPDB Length = 302 Score = 236 bits (603), Expect = 2e-62, Method: Composition-based stats. Identities = 64/271 (23%), Positives = 115/271 (42%), Gaps = 16/271 (5%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTRVAI-KTLK-PGTMSPEAFLQEAQVMKKLRHE 323 P E + +LG G FG+V+ T +A K ++ E ++ E +++ H Sbjct: 17 PNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHP 76 Query: 324 KLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V+L + ++I+ E+ G++ D + E + L PQ+ + Q+ + ++ Sbjct: 77 YIVKLLGAYYHDGKLWIMIEFCPGGAV-DAIMLELDRGLTEPQIQVVCRQMLEALNFLHS 135 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG-- 440 +HRDL+A N+L+ ++ADFG++ R W APE + Sbjct: 136 KRIIHRDLKAGNVLMTLEGDIRLADFGVSAK-NLKTLQKRDSFIGTPYWMAPEVVMCETM 194 Query: 441 ---RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPC--PPECPESLH 495 + K+D+WS GI L E+ P+ + VL ++ + P + Sbjct: 195 KDTPYDYKADIWSLGITLIEMAQI-EPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFR 253 Query: 496 DLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 D + K PE RP+ L LE F S+ Sbjct: 254 DFLKIALDKNPETRPSAAQL---LEHPFVSS 281 >4RLP-A nrPDB Length = 288 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 58/256 (22%), Positives = 114/256 (44%), Gaps = 15/256 (5%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTW---NGTTRV-AIKTLKP-----GTMSPEAFLQEA 314 +I E L LG+G +G+V+ T ++ A+K LK E Sbjct: 1 KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAER 60 Query: 315 QVMKKLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373 ++++++H +V L YA + +Y++ EY+S G L F++ E A+I Sbjct: 61 NILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGEL--FMQLEREGIFMEDTACFYLAEI 118 Query: 374 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 433 + + ++ + ++RDL+ NI++ K+ DFGL + + I++ A Sbjct: 119 SMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFC-GTIEYMA 177 Query: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES 493 PE + D WS G L+ ++ T G P+ G ++ +D++ + ++ PP + Sbjct: 178 PEILMRSGHNRAVDWWSLGALMYDMLT-GAPPFTGENRKKTIDKILK-CKLNLPPYLTQE 235 Query: 494 LHDLMCQCWRKEPEER 509 DL+ + ++ R Sbjct: 236 ARDLLKKLLKRNAASR 251 >4RGJ-A nrPDB Length = 520 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 71/276 (25%), Positives = 124/276 (44%), Gaps = 23/276 (8%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPG----TMSPEAFLQEAQVMKKLRH 322 E + LG+G FGEV + T AIK + E+ L+E +++K L H Sbjct: 60 EQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTDKESLLREVELLKMLDH 119 Query: 323 EKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 +++LY + Y +V++ + G L D + Y + QI SG+ Y+ Sbjct: 120 INIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFY--EIDAARIIKQILSGITYMH 177 Query: 382 RMNYVHRDLRAANILV----GENLVCKVADFGLARLIEDNEYTARQGAK-FPIKWTAPEA 436 + N VHRDL+ NIL+ E+++ K+ DFGL+ EY+ + K + AP+ Sbjct: 178 KNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHF---EYSKKMKDKIGTAYYIAPDV 234 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPCPPECPES 493 +G + K D+WS G++L L + G P+ G ++L +VE G + +P + + Sbjct: 235 L-HGTYDEKCDIWSCGVILYILLS-GCPPFNGSNEYDILKKVEAGKYTFDLPQFKKISDK 292 Query: 494 LHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 DL+ + R + A ++ + Sbjct: 293 AKDLIKKMLMYTSAVRISARD--ALEHEWIKMMTSK 326 >5DBX-A nrPDB Length = 328 Score = 236 bits (602), Expect = 2e-62, Method: Composition-based stats. Identities = 75/278 (26%), Positives = 121/278 (43%), Gaps = 25/278 (8%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLK--PGTMSPEAFLQEAQVMKK 319 W I R++ L+ +G G V RVAIK + S + L+E Q M + Sbjct: 6 WPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQ 65 Query: 320 LRHEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLK------GETGKYLRLPQLVDMAAQ 372 H +V Y + V ++ +++V + +S GS+LD +K L + + + Sbjct: 66 CSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKE 125 Query: 373 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK----FP 428 + G+ Y+ R +HRDL+A NIL+GE+ ++ADFG++ + R + Sbjct: 126 VLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKDFVGT 185 Query: 429 IKWTAPEAALY-GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP 487 W APE + K+D+WSFGI EL T G PY +VL + Sbjct: 186 PCWMAPEVMEQVRGYDFKADMWSFGITAIELAT-GAAPYHKYPPMKVLMLTLQNDPPTLE 244 Query: 488 ---------PECPESLHDLMCQCWRKEPEERPTFEYLQ 516 + +S L+ C +K+P +RPT L Sbjct: 245 TGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELL 282 >5HVK-A nrPDB Length = 315 Score = 236 bits (601), Expect = 3e-62, Method: Composition-based stats. Identities = 90/274 (32%), Positives = 128/274 (46%), Gaps = 22/274 (8%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRVAI-K-TLKPGTMSPEAFLQEAQVMKKLRHEKL 325 L LG+GCFG+ T T V + K ++ + FL+E +VM+ L H + Sbjct: 14 SDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNV 73 Query: 326 VQLYAV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN 384 ++ V ++ + +TEY+ G+L +K +Y Q V A IASGMAY+ MN Sbjct: 74 LKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQY-PWSQRVSFAKDIASGMAYLHSMN 132 Query: 385 YVHRDLRAANILVGENLVCKVADFGLARLIEDN-------------EYTARQGAKFPIKW 431 +HR+L + N LV EN VADFGLARL+ D + R W Sbjct: 133 IIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYW 192 Query: 432 TAPEAALYGRFTIKSDVWSFGILLTELTTKGRV---PYPGMVNREVLDQVERGYRMPCPP 488 APE + K DV+SFGI+L E+ GRV P + V CPP Sbjct: 193 MAPEMINGRSYDEKVDVFSFGIVLCEII--GRVNADPDYLPRTMDFGLNVRGFLDRYCPP 250 Query: 489 ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 CP S + +C +PE+RP+F L+ +LE Sbjct: 251 NCPPSFFPITVRCCDLDPEKRPSFVKLEHWLETL 284 >2UV2-A nrPDB Length = 325 Score = 236 bits (601), Expect = 3e-62, Method: Composition-based stats. Identities = 64/273 (23%), Positives = 112/273 (41%), Gaps = 16/273 (5%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLK-PGTMSPEAFLQEAQVMKKLRHE 323 P + + +LG G FG+V+ T+ A K + E ++ E ++ H Sbjct: 35 PEDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMVEIDILASCDHP 94 Query: 324 KLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V+L E ++I+ E+ + G++ D + E + L Q+ + Q + Y+ Sbjct: 95 NIVKLLDAFYYENNLWILIEFCAGGAV-DAVMLELERPLTESQIQVVCKQTLDALNYLHD 153 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL---- 438 +HRDL+A NIL + K+ADFG++ R W APE + Sbjct: 154 NKIIHRDLKAGNILFTLDGDIKLADFGVSAK-NTRTIQRRDSFIGTPYWMAPEVVMCETS 212 Query: 439 -YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP--CPPECPESLH 495 + K+DVWS GI L E+ P+ + VL ++ + P + Sbjct: 213 KDRPYDYKADVWSLGITLIEMAEI-EPPHHELNPMRVLLKIAKSEPPTLAQPSRWSSNFK 271 Query: 496 DLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEP 528 D + +C K + R T L L+ F + + Sbjct: 272 DFLKKCLEKNVDARWTTSQL---LQHPFVTVDS 301 >6FD3-A nrPDB Length = 300 Score = 235 bits (600), Expect = 3e-62, Method: Composition-based stats. Identities = 61/270 (22%), Positives = 111/270 (41%), Gaps = 12/270 (4%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTM-SPEAFLQEAQVMKKLRHE 323 P++ K+GQG G V+ T + VAIK + E + E VM++ ++ Sbjct: 20 PKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNP 79 Query: 324 KLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V + + +++V EY++ GSL D + T + Q+ + + + ++ Sbjct: 80 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALDFLHS 136 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 +HRD+++ NIL+G + K+ DFG I E + R W APE + Sbjct: 137 NQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP-EQSKRSTMVGTPYWMAPEVVTRKAY 195 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG--YRMPCPPECPESLHDLMCQ 500 K D+WS GI+ E+ +G PY L + + P D + + Sbjct: 196 GPKVDIWSLGIMAIEM-VEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNR 254 Query: 501 CWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 C + + R + + L + +P Sbjct: 255 CLEMDVDRRGSAKELLQ--HPFLKLDKPLS 282 >4B6L-A nrPDB Length = 281 Score = 235 bits (599), Expect = 4e-62, Method: Composition-based stats. Identities = 70/265 (26%), Positives = 112/265 (42%), Gaps = 14/265 (5%) Query: 267 RESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKP----GTMSPEAFLQEAQVMKKLR 321 R L+ LG+G F + T T A+K + E L E ++ + L+ Sbjct: 9 RTYLK-GRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQ 67 Query: 322 HEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 H +V+ + + IYI E S+ SL K L P++ QI SG+ Y+ Sbjct: 68 HRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKAR--HTLLEPEVRYYLRQILSGLKYL 125 Query: 381 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 440 + +HRDL+ N + EN+ KV DFGLA +E E + P + APE L Sbjct: 126 HQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTP-NYVAPEVLLRQ 184 Query: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQ 500 ++DVWS G ++ L G P+ +E +++ + P L+ Sbjct: 185 GHGPEADVWSLGCVMYTLLC-GSPPFETADLKETYRCIKQVH-YTLPASLSLPARQLLAA 242 Query: 501 CWRKEPEERPTFEYLQAFLEDYFTS 525 R P +RP+ + + D+FT Sbjct: 243 ILRASPRDRPSIDQI--LRHDFFTK 265 >4YZB-A nrPDB Length = 491 Score = 234 bits (598), Expect = 5e-62, Method: Composition-based stats. Identities = 69/272 (25%), Positives = 126/272 (46%), Gaps = 20/272 (7%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEA----FLQEAQVMKKLRH 322 + + + LG+G FGEV + T + A+K + + + L+E +++KKL H Sbjct: 30 DRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVELLKKLDH 89 Query: 323 EKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 +++LY ++ Y+VTE + G L D + K + Q+ SG+ Y+ Sbjct: 90 PNIMKLYEFFEDKGYFYLVTEVYTGGELFDEIISR--KRFSEVDAARIIRQVLSGITYMH 147 Query: 382 RMNYVHRDLRAANILVGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438 + VHRDL+ N+L+ + ++ DFGL+ E + + + APE Sbjct: 148 KNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTK--KMKDKIGTAYYIAPEVL- 204 Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPCPPECPESLH 495 +G + K DVWS G++L L + G P+ G ++L +VE+G + +P + E Sbjct: 205 HGTYDEKCDVWSTGVILYILLS-GCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAK 263 Query: 496 DLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE 527 DL+ + P R + A ++ +T+ Sbjct: 264 DLIRKMLAYVPTMRISARD--ALEHEWLKTTD 293 >3IS5-A nrPDB Length = 285 Score = 234 bits (598), Expect = 6e-62, Method: Composition-based stats. Identities = 78/270 (28%), Positives = 128/270 (47%), Gaps = 21/270 (7%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTT--RVAIKTLKPGTMSP--EAFLQEAQVMKKLRHEKL 325 + KLG G FG+V + + RV IKT+ E E +V+K L H + Sbjct: 24 FIFKRKLGSGAFGDVHLVEERSSGLERV-IKTINKDRSQVPMEQIEAEIEVLKSLDHPNI 82 Query: 326 VQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGE--TGKYLRLPQLVDMAAQIASGMAYVER 382 ++++ V + +YIV E G LL+ + GK L + ++ Q+ + +AY Sbjct: 83 IKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNALAYFHS 142 Query: 383 MNYVHRDLRAANILVGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 + VH+DL+ NIL + + K+ DFGLA L + +E++ A + APE Sbjct: 143 QHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTN--AAGTALYMAPEVF-K 199 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV---ERGYRMPCPPECPESLHD 496 T K D+WS G+++ L T G +P+ G EV + E Y + C P P+++ D Sbjct: 200 RDVTFKCDIWSAGVVMYFLLT-GCLPFTGTSLEEVQQKATYKEPNYAVECRPLTPQAV-D 257 Query: 497 LMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 L+ Q K+PE RP+ + ++F Sbjct: 258 LLKQMLTKDPERRPSAAQVLH--HEWFKQA 285 >3SOA-A nrPDB Length = 444 Score = 234 bits (598), Expect = 6e-62, Method: Composition-based stats. Identities = 64/268 (23%), Positives = 110/268 (41%), Gaps = 17/268 (6%) Query: 268 ESLRLEVKLGQGCFGEVWMG-TWNGTTRVA---IKTLKPGTMSPEAFLQEAQVMKKLRHE 323 E +L +LG+G F V A I T K + +EA++ + L+H Sbjct: 11 EEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARICRLLKHP 70 Query: 324 KLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V+L+ +SEE Y++ + ++ G L + + +Y QI + + + Sbjct: 71 NIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAR--EYYSEADASHCIQQILEAVLHCHQ 128 Query: 383 MNYVHRDLRAANILVGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 M VHR+L+ N+L+ K+ADFGLA +E E A G + +PE Sbjct: 129 MGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVE-GEQQAWFGFAGTPGYLSPEVLRK 187 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG-YRMPCPPE--CPESLHD 496 + D+W+ G++L L G P+ + Q++ G Y P P D Sbjct: 188 DPYGKPVDLWACGVILYILLV-GYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKD 246 Query: 497 LMCQCWRKEPEERPTFEYLQAFLEDYFT 524 L+ + P +R T A + + Sbjct: 247 LINKMLTINPSKRITAAE--ALKHPWIS 272 >4RA4-A nrPDB Length = 355 Score = 234 bits (597), Expect = 7e-62, Method: Composition-based stats. Identities = 63/253 (24%), Positives = 113/253 (44%), Gaps = 12/253 (4%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPG----TMSPEAFLQEAQVMK 318 + + LG+G FG+V + GT AIK LK E + E +V+ Sbjct: 16 RVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLA 75 Query: 319 KLRHE-KLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 L L QL++ + + +Y V EY++ G L+ ++ + PQ V AA+I+ G Sbjct: 76 LLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVG--KFKEPQAVFYAAEISIG 133 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 + ++ + ++RDL+ N+++ K+ADFG+ + + T R P + APE Sbjct: 134 LFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTP-DYIAPEI 192 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 Y + D W++G+LL E+ G+ P+ G E+ + + + P + Sbjct: 193 IAYQPYGKSVDWWAYGVLLYEMLA-GQPPFDGEDEDELFQSIME-HNVSYPKSLSKEAVS 250 Query: 497 LMCQCWRKEPEER 509 + K P +R Sbjct: 251 ICKGLMTKHPAKR 263 >3DB8-A nrPDB Length = 317 Score = 234 bits (597), Expect = 7e-62, Method: Composition-based stats. Identities = 61/259 (23%), Positives = 108/259 (41%), Gaps = 13/259 (5%) Query: 273 EVKLGQGCFGEVWMGTWNGTTRV-AIKTLKP----GTMSPEAFLQEAQVMKKLRHEKLVQ 327 LG+G F + + T T V A K + E E + K L + +V Sbjct: 47 GRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNPHVVG 106 Query: 328 LYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 + ++ +Y+V E + SLL+ K K + P+ Q G+ Y+ + Sbjct: 107 FHGFFEDDDFVYVVLEICRRRSLLELHKRR--KAVTEPEARYFMRQTIQGVQYLHNNRVI 164 Query: 387 HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 446 HRDL+ N+ + +++ K+ DFGLA IE + + P + APE + + Sbjct: 165 HRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTP-NYIAPEVLCKKGHSFEV 223 Query: 447 DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEP 506 D+WS G +L L G+ P+ +E ++++ P L+ + +P Sbjct: 224 DIWSLGCILYTLLV-GKPPFETSCLKETYIRIKKN-EYSVPRHINPVASALIRRMLHADP 281 Query: 507 EERPTFEYLQAFLEDYFTS 525 RP+ L +++FTS Sbjct: 282 TLRPSVAEL--LTDEFFTS 298 >5EFQ-A nrPDB Length = 347 Score = 234 bits (596), Expect = 9e-62, Method: Composition-based stats. Identities = 76/321 (23%), Positives = 129/321 (40%), Gaps = 55/321 (17%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLK---PGTMSPEAFLQEAQVMKKLRHE 323 + + +G+G +G+V+ T VA+K ++ P ++E +++++L H+ Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 70 Query: 324 KLVQLYAVVSEEP-----------IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQ 372 ++ + +V+++ Y+V EYM L+ L+ + + Q Sbjct: 71 SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH-DLMGLLES-GLVHFNENHIKSFMRQ 128 Query: 373 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT 432 + G+ Y + N++HRD++ +NIL+ K+ADFGLARL E + + Sbjct: 129 LMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYR 188 Query: 433 APEAALYG-RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP 491 PE L R+T DVWS G +L EL TK + + L+ + R PCP P Sbjct: 189 PPELLLGEERYTPAIDVWSCGCILGELFTK-KPIFQANQELAQLELISRICGSPCPAVWP 247 Query: 492 ESLH-----------------------------DLMCQCWRKEPEERPTFEY-LQ-AFLE 520 + + DL +P +R T E LQ FL Sbjct: 248 DVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLR 307 Query: 521 DYFTS-----TEPQYQPGENL 536 D S P +Q L Sbjct: 308 DVEPSKMPPPDLPLWQDCHEL 328 >5F9E-A nrPDB Length = 353 Score = 234 bits (596), Expect = 9e-62, Method: Composition-based stats. Identities = 67/253 (26%), Positives = 119/253 (47%), Gaps = 12/253 (4%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPG----TMSPEAFLQEAQVMK 318 ++ E L LG+G FG+V++ + T + AIK LK E + E +V+ Sbjct: 15 KLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLS 74 Query: 319 KL-RHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 H L ++ ++E ++ V EY++ G L+ ++ L + AA+I G Sbjct: 75 LAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQS--CHKFDLSRATFYAAEIILG 132 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 + ++ V+RDL+ NIL+ ++ K+ADFG+ + + + P + APE Sbjct: 133 LQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTP-DYIAPEI 191 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 L ++ D WSFG+LL E+ G+ P+ G E+ + R P + D Sbjct: 192 LLGQKYNHSVDWWSFGVLLYEML-IGQSPFHGQDEEELFHSI-RMDNPFYPRWLEKEAKD 249 Query: 497 LMCQCWRKEPEER 509 L+ + + +EPE+R Sbjct: 250 LLVKLFVREPEKR 262 >3F3Z-A nrPDB Length = 277 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 66/267 (24%), Positives = 115/267 (43%), Gaps = 17/267 (6%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTT--RVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKL 325 + LE +G+G +GEV + GT R A K K + F QE ++MK L H + Sbjct: 9 QYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVDRFKQEIEIMKSLDHPNI 68 Query: 326 VQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN 384 ++LY + IY+V E + G L + + + + R + + S +AY ++N Sbjct: 69 IRLYETFEDNTDIYLVMELCTGGELFERVVHK--RVFRESDAARIMKDVLSAVAYCHKLN 126 Query: 385 YVHRDLRAANILV---GENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 HRDL+ N L + K+ DFGLA + + + + +P+ G Sbjct: 127 VAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKV--GTPYYVSPQVL-EGL 183 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC---PESLHDLM 498 + + D WS G+++ L G P+ + EV+ ++ G + L+ Sbjct: 184 YGPECDEWSAGVMMYVLLC-GYPPFSAPTDSEVMLKIREGTFTFPEKDWLNVSPQAESLI 242 Query: 499 CQCWRKEPEERPTFEYLQAFLEDYFTS 525 + K P++R T LQA ++F Sbjct: 243 RRLLTKSPKQRIT--SLQALEHEWFEK 267 >2F57-A nrPDB Length = 317 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 58/256 (22%), Positives = 113/256 (44%), Gaps = 10/256 (3%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLK-PGTMSPEAFLQEAQVMKKLRHE 323 PRE L +K+G+G G V + T T + VA+K + E E +M+ H+ Sbjct: 43 PREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHD 102 Query: 324 KLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V +Y+ + + +++V E++ G+L D + T + Q+ + + ++Y+ Sbjct: 103 NVVDMYSSYLVGDELWVVMEFLEGGALTDIV---THTRMNEEQIATVCLSVLRALSYLHN 159 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 +HRD+++ +IL+ + K++DFG + E R+ W APE + Sbjct: 160 QGVIHRDIKSDSILLTSDGRIKLSDFGFCAQV-SKEVPKRKSLVGTPYWMAPEVISRLPY 218 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP--ECPESLHDLMCQ 500 + D+WS GI++ E+ G PY + + ++ + L + Sbjct: 219 GTEVDIWSLGIMVIEMI-DGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDL 277 Query: 501 CWRKEPEERPTFEYLQ 516 +EP +R T + L Sbjct: 278 MLVREPSQRATAQELL 293 >3Q53-A nrPDB Length = 306 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 61/270 (22%), Positives = 113/270 (41%), Gaps = 12/270 (4%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTM-SPEAFLQEAQVMKKLRHE 323 P++ K+GQG G V+ T + VAI+ + E + E VM++ ++ Sbjct: 19 PKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKELIINEILVMRENKNP 78 Query: 324 KLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V + + +++V EY++ GSL D + T + Q+ + + + ++ Sbjct: 79 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVV---TETCMDEGQIAAVCRECLQALEFLHS 135 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 +HRD+++ NIL+G + K+ DFG I E + R W APE + Sbjct: 136 NQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP-EQSKRSTMVGTPYWMAPEVVTRKAY 194 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG--YRMPCPPECPESLHDLMCQ 500 K D+WS GI+ E+ +G PY L + + P + D + + Sbjct: 195 GPKVDIWSLGIMAIEMI-EGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNR 253 Query: 501 CWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 C + E+R + + L + +P Sbjct: 254 CLEMDVEKRGSAKEL--IQHQFLKIAKPLS 281 >4J52-A nrPDB Length = 293 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 64/256 (25%), Positives = 110/256 (42%), Gaps = 13/256 (5%) Query: 276 LGQGCFGEVWMGTWNGTTRVAI-----KTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYA 330 LG+G F + + + T V K+L E E + + L H+ +V + Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 81 Query: 331 VVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 + +++V E + SLL+ K K L P+ QI G Y+ R +HRD Sbjct: 82 FFEDNDFVFVVLELCRRRSLLELHKRR--KALTEPEARYYLRQIVLGCQYLHRNRVIHRD 139 Query: 390 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 449 L+ N+ + E+L K+ DFGLA +E + + P + APE + + DVW Sbjct: 140 LKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTP-NYIAPEVLSKKGHSFEVDVW 198 Query: 450 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEER 509 S G ++ L G+ P+ +E ++++ P L+ + + +P R Sbjct: 199 SIGCIMYTLLV-GKPPFETSCLKETYLRIKKN-EYSIPKHINPVAASLIQKMLQTDPTAR 256 Query: 510 PTFEYLQAFLEDYFTS 525 PT L +++FTS Sbjct: 257 PTINELLN--DEFFTS 270 >2OU7-A nrPDB Length = 335 Score = 233 bits (594), Expect = 2e-61, Method: Composition-based stats. Identities = 64/256 (25%), Positives = 110/256 (42%), Gaps = 13/256 (5%) Query: 276 LGQGCFGEVWMGTWNGTTRVAI-----KTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYA 330 LG+G F + + + T V K+L E E + + L H+ +V + Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHG 108 Query: 331 VVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 + +++V E + SLL+ K K L P+ QI G Y+ R +HRD Sbjct: 109 FFEDNDFVFVVLELCRRRSLLELHKRR--KALTEPEARYYLRQIVLGCQYLHRNRVIHRD 166 Query: 390 LRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVW 449 L+ N+ + E+L K+ DFGLA +E + + P + APE + + DVW Sbjct: 167 LKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTP-NYIAPEVLSKKGHSFEVDVW 225 Query: 450 SFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEER 509 S G ++ L G+ P+ +E ++++ P L+ + + +P R Sbjct: 226 SIGCIMYTLLV-GKPPFETSCLKETYLRIKKN-EYSIPKHINPVAASLIQKMLQTDPTAR 283 Query: 510 PTFEYLQAFLEDYFTS 525 PT L +++FTS Sbjct: 284 PTINELLN--DEFFTS 297 >6CMJ-A nrPDB Length = 321 Score = 233 bits (594), Expect = 2e-61, Method: Composition-based stats. Identities = 72/293 (24%), Positives = 131/293 (44%), Gaps = 29/293 (9%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTW-NGTTRVAIKTLKPGTMSP------------EAFL 311 + + L+ ++G+G +G V + N T A+K L + E Sbjct: 31 VQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVY 90 Query: 312 QEAQVMKKLRHEKLVQLYAVVSE---EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD 368 QE ++KKL H +V+L V+ + + +Y+V E +++G +++ T K L Q Sbjct: 91 QEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEV---PTLKPLSEDQARF 147 Query: 369 MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFP 428 + G+ Y+ +HRD++ +N+LVGE+ K+ADFG++ + ++ Sbjct: 148 YFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSD-ALLSNTVGT 206 Query: 429 IKWTAPEAALYGR--FTIKS-DVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-RGYRM 484 + APE+ R F+ K+ DVW+ G+ L G+ P+ + +++ + Sbjct: 207 PAFMAPESLSETRKIFSGKALDVWAMGVTLY-CFVFGQCPFMDERIMCLHSKIKSQALEF 265 Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTS--TEPQYQPGEN 535 P P+ E L DL+ + K PE R ++ L + T EP EN Sbjct: 266 PDQPDIAEDLKDLITRMLDKNPESRIVVPEIK--LHPWVTRHGAEPLPSEDEN 316 >4KRC-A nrPDB Length = 317 Score = 232 bits (593), Expect = 2e-61, Method: Composition-based stats. Identities = 70/298 (23%), Positives = 121/298 (40%), Gaps = 47/298 (15%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMS--PEAFLQEAQVMKKLRHEK 324 + KLG G + V+ G T VA+K +K + P ++E +MK+L+HE Sbjct: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGTPSTAIREISLMKELKHEN 64 Query: 325 LVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGET----GKYLRLPQLVDMAAQIASGMAY 379 +V+LY V+ +E + +V E+M L ++ T + L L + Q+ G+A+ Sbjct: 65 IVRLYDVIHTENKLTLVFEFMDN-DLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAF 123 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 +HRDL+ N+L+ + K+ DFGLAR + + AP+ + Sbjct: 124 CHENKILHRDLKPQNLLINKRGQLKLGDFGLARAF-GIPVNTFSSEVVTLWYRAPDVLMG 182 Query: 440 GR-FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE------ 492 R ++ D+WS G +L E+ T G+ +PG + E L + P P Sbjct: 183 SRTYSTSIDIWSCGCILAEMIT-GKPLFPGTNDEEQLKLIFDIMGTPNESLWPSVTKLPK 241 Query: 493 ---------------------------SLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 +L D + + P+ R + + QA +F Sbjct: 242 YNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAK--QALHHPWF 297 >4WNO-A nrPDB Length = 287 Score = 232 bits (592), Expect = 3e-61, Method: Composition-based stats. Identities = 68/277 (24%), Positives = 117/277 (42%), Gaps = 26/277 (9%) Query: 270 LRLEVK--LGQGCFGEVWMGTWNG--TTRVAIKTLKPGTMSPEAFL--QEAQVMKKLRHE 323 K +G G F V+ G VA+K + ++ L +E +++K+L+HE Sbjct: 18 FEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHE 77 Query: 324 KLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V LY +Y+V EY + G L D+L + L + QIA M + Sbjct: 78 NIVALYDFQEMANSVYLVMEYCNGGDLADYLHA--MRTLSEDTIRLFLQQIAGAMRLLHS 135 Query: 383 MNYVHRDLRAANILVG---------ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 433 +HRDL+ NIL+ ++ K+ADFG AR ++ N A + A Sbjct: 136 KGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAA--TLCGSPMYMA 193 Query: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM--PCPPECP 491 PE + + K+D+WS G ++ + T G+ P+ +++ E+ + P E Sbjct: 194 PEVIMSQHYDGKADLWSIGTIVYQCLT-GKAPFQASSPQDLRLFYEKNKTLVPTIPRETS 252 Query: 492 ESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEP 528 L L+ ++ ++R F+ F F P Sbjct: 253 APLRQLLLALLQRNHKDRMDFDE---FFHHPFLDASP 286 >5WAX-A nrPDB Length = 310 Score = 232 bits (591), Expect = 4e-61, Method: Composition-based stats. Identities = 60/273 (21%), Positives = 106/273 (38%), Gaps = 17/273 (6%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324 + L +G G FG + + VA+K ++ G E +E + LRH Sbjct: 9 DGDRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDENVQREIINHRSLRHPN 68 Query: 325 LVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 +++ V+ + + IV EY S G L + + + Q+ SG++Y M Sbjct: 69 IIRFKEVILTPTHLAIVMEYASGGELFERICN--AGRFSEDEARFFFQQLISGVSYCHSM 126 Query: 384 NYVHRDLRAANILVGENLV--CKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 HRDL+ N L+ + K+ DFG ++ ++ + + APE L Sbjct: 127 QVCHRDLKLENTLLDGSTAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLLKKE 184 Query: 442 FTIKS-DVWSFGILLTELTTKGRVPYPGMVN----REVLDQVER-GYRMPCPPECPESLH 495 + K DVWS G+ L + G P+ R+ + ++ Y +P Sbjct: 185 YDGKVADVWSCGVTLYVMLV-GAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPECQ 243 Query: 496 DLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEP 528 DL+ + + P R T ++ +F P Sbjct: 244 DLISRIFVANPATRITIPEIRN--HPWFLKNLP 274 >6GU6-A nrPDB Length = 302 Score = 231 bits (590), Expect = 4e-61, Method: Composition-based stats. Identities = 72/298 (24%), Positives = 126/298 (42%), Gaps = 40/298 (13%) Query: 267 RESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMS---PEAFLQEAQVMKKLRH 322 E K+G+G +G V+ G T +V A+K ++ + P ++E ++K+LRH Sbjct: 6 MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 65 Query: 323 EKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKG-ETGKYLRLPQLVDMAAQIASGMAYV 380 +V L V+ ++ +Y++ E++S L +L G+Y+ + QI G+ + Sbjct: 66 PNIVSLQDVLMQDSRLYLIFEFLSM-DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFC 124 Query: 381 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 440 +HRDL+ N+L+ + K+ADFGLAR + + +PE L Sbjct: 125 HSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAF-GIPIRVYTHEVVTLWYRSPEVLLGS 183 Query: 441 -RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP-------------- 485 R++ D+WS G + EL TK + + G + L ++ R P Sbjct: 184 ARYSTPVDIWSIGTIFAELATK-KPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDY 242 Query: 486 ---CPPECPESLH-----------DLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 P P SL DL+ + +P +R + + A YF + Q Sbjct: 243 KNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGK--MALNHPYFNDLDNQ 298 >3HDN-A nrPDB Length = 373 Score = 231 bits (590), Expect = 5e-61, Method: Composition-based stats. Identities = 62/272 (22%), Positives = 114/272 (41%), Gaps = 18/272 (6%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTM----SPEAFLQEAQVM-KKLR 321 +G+G FG+V + A+K L+ + + + E V+ K ++ Sbjct: 38 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVK 97 Query: 322 HEKLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 H LV L+ + + + +Y V +Y++ G L L+ E + P+ AA+IAS + Y+ Sbjct: 98 HPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRE--RCFLEPRARFYAAEIASALGYL 155 Query: 381 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 440 +N V+RDL+ NIL+ + DFGL + ++ T P ++ APE Sbjct: 156 HSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTP-EYLAPEVLHKQ 214 Query: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQ 500 + D W G +L E+ G P+ E+ D + + P S L+ Sbjct: 215 PYDRTVDWWCLGAVLYEML-YGLPPFYSRNTAEMYDNILNK-PLQLKPNITNSARHLLEG 272 Query: 501 CWRKEPEERP----TFEYLQAFLEDYFTSTEP 528 +K+ +R F +++ +F+ Sbjct: 273 LLQKDRTKRLGAKDDFMEIKS--HVFFSLINW 302 >4NIF-A nrPDB Length = 333 Score = 231 bits (589), Expect = 7e-61, Method: Composition-based stats. Identities = 64/277 (23%), Positives = 114/277 (41%), Gaps = 24/277 (8%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSPEAFLQEAQVM-KKLRHEKLVQ 327 ++ +G G + E T A+K + P +E +++ + +H ++ Sbjct: 10 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPS---EEIEILLRYGQHPNIIT 66 Query: 328 LYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 L V + + +Y+VTE M G LLD + + K+ + + I + Y+ V Sbjct: 67 LKDVYDDGKHVYLVTELMRGGELLDKILRQ--KFFSEREASFVLHTIGKTVEYLHSQGVV 124 Query: 387 HRDLRAANIL-VGENLV---CKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 HRDL+ +NIL V E+ ++ DFG A+ + E + + APE + Sbjct: 125 HRDLKPSNILYVDESGNPECLRICDFGFAKQLR-AENGLLMTPCYTANFVAPEVLKRQGY 183 Query: 443 TIKSDVWSFGILLTELTTKGRVPY---PGMVNREVLDQVERGYRMPCPPEC---PESLHD 496 D+WS GILL + G P+ P E+L ++ G E+ D Sbjct: 184 DEGCDIWSLGILLYTMLA-GYTPFANGPSDTPEEILTRIGSGKFTLSGGNWNTVSETAKD 242 Query: 497 LMCQCWRKEPEERPTFEYLQAFLEDYFTSTE--PQYQ 531 L+ + +P +R T + + + T + PQ Q Sbjct: 243 LVSKMLHVDPHQRLTAKQVLQ--HPWVTQKDKLPQSQ 277 >4YFF-A nrPDB Length = 311 Score = 231 bits (588), Expect = 8e-61, Method: Composition-based stats. Identities = 77/278 (27%), Positives = 127/278 (45%), Gaps = 13/278 (4%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA----FLQEAQ 315 + + + +G G FG+V+ G VAIK + T ++ F +E Sbjct: 34 PSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKI-VAIKRYRANTYCSKSDVDMFCREVS 92 Query: 316 VMKKLRHEKLVQLYAVVSEEP--IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373 ++ +L H ++Q +P IVT+Y+S GSL L + + L L + +A + Sbjct: 93 ILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQK-RILDLQSKLIIAVDV 151 Query: 374 ASGMAYVER--MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKW 431 A GM Y+ +HRDL + NIL+ E+ VADFG +R ++ + ++W Sbjct: 152 AKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRW 211 Query: 432 TAPEAALYG-RFTIKSDVWSFGILLTELTTKGRVPYPGMVN-REVLDQVERGYRMPCPPE 489 APE R+TIK+DV+S+ + L E+ T G +P+ + D R P Sbjct: 212 MAPEVFTQCTRYTIKADVFSYALCLWEILT-GEIPFAHLKPAAAAADMAYHHIRPPIGYS 270 Query: 490 CPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE 527 P+ + L+ + W PE RP F + LE+ + E Sbjct: 271 IPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIE 308 >4JG6-A nrPDB Length = 355 Score = 231 bits (588), Expect = 9e-61, Method: Composition-based stats. Identities = 68/301 (22%), Positives = 120/301 (39%), Gaps = 30/301 (9%) Query: 252 KPQTQGLAKDAWEIPRESLRL------EVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGT 304 K QT G+ ++ R S++ + +G G + T A+K + Sbjct: 13 KMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSK 72 Query: 305 MSPEAFLQEAQVM-KKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLR 362 P +E +++ + +H ++ L V + +Y+VTE M G LLD + + K+ Sbjct: 73 RDP---TEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQ--KFFS 127 Query: 363 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANIL-VGENLV---CKVADFGLARLIEDNE 418 + + I + Y+ VHRDL+ +NIL V E+ ++ DFG A+ + E Sbjct: 128 EREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLR-AE 186 Query: 419 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPY---PGMVNREVL 475 + + APE + D+WS G+LL + T G P+ P E+L Sbjct: 187 NGLLMTPCYTANFVAPEVLERQGYDAACDIWSLGVLLYTMLT-GYTPFANGPDDTPEEIL 245 Query: 476 DQVERGYRMP---CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF--TSTEPQY 530 ++ G ++ DL+ + +P +R T + PQY Sbjct: 246 ARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAA--LVLRHPWIVHWDQLPQY 303 Query: 531 Q 531 Q Sbjct: 304 Q 304 >2J90-A nrPDB Length = 304 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 64/290 (22%), Positives = 119/290 (41%), Gaps = 23/290 (7%) Query: 261 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMS-------PEAFLQ 312 + + + +LG G F V GT + A K +K +S E + Sbjct: 19 YFQSMVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIER 78 Query: 313 EAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA 371 E +++++RH ++ L+ + + + ++ E +S G L DFL + + L + Sbjct: 79 EVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEK--ESLTEDEATQFLK 136 Query: 372 QIASGMAYVERMNYVHRDLRAANILVGE----NLVCKVADFGLARLIEDNEYTARQGAKF 427 QI G+ Y+ H DL+ NI++ + N K+ DFG+A IE + Sbjct: 137 QILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAG--NEFKNIFG 194 Query: 428 PIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV---ERGYRM 484 ++ APE Y +++D+WS G++ L + G P+ G +E L + + Sbjct: 195 TPEFVAPEIVNYEPLGLEADMWSIGVITYILLS-GASPFLGETKQETLTNISAVNYDFDE 253 Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGE 534 E D + + K+P+ R T Q+ + + + GE Sbjct: 254 EYFSNTSELAKDFIRRLLVKDPKRRMTIA--QSLEHSWIKAIRRRNVRGE 301 >1G3N-A nrPDB Length = 326 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 68/316 (21%), Positives = 127/316 (40%), Gaps = 53/316 (16%) Query: 268 ESLRLEVKLGQGCFGEVWMGTW--NGTTRVAIKTLKPGTMS---PEAFLQEAQVMKKLR- 321 + ++G+G +G+V+ NG VA+K ++ T P + ++E V++ L Sbjct: 11 QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70 Query: 322 --HEKLVQLYAVVS------EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373 H +V+L+ V + E + +V E++ + L +L + + DM Q+ Sbjct: 71 FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQ-DLTTYLDKVPEPGVPTETIKDMMFQL 129 Query: 374 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 433 G+ ++ VHRDL+ NILV + K+ADFGLAR+ A + + A Sbjct: 130 LRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYS--FQMALTSVVVTLWYRA 187 Query: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES 493 PE L + D+WS G + E+ + + + G + + L ++ +P + P Sbjct: 188 PEVLLQSSYATPVDLWSVGCIFAEMF-RRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 246 Query: 494 L--------------------------HDLMCQCWRKEPEERPT---------FEYLQAF 518 + DL+ +C P +R + F+ L+ Sbjct: 247 VALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERC 306 Query: 519 LEDYFTSTEPQYQPGE 534 E+ + P E Sbjct: 307 KENLDSHLPPSQNTSE 322 >4NST-A nrPDB Length = 351 Score = 230 bits (586), Expect = 2e-60, Method: Composition-based stats. Identities = 74/323 (22%), Positives = 129/323 (39%), Gaps = 59/323 (18%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLK---PGTMSPEAFLQEAQVMKKLRHE 323 + + +G+G +G+V+ T VA+K ++ P ++E +++++L H Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHR 72 Query: 324 KLVQLYAVVSEEP-----------IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQ 372 +V + +V+++ Y+V EYM L+ L+ + + Q Sbjct: 73 SVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH-DLMGLLES-GLVHFSEDHIKSFMKQ 130 Query: 373 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT 432 + G+ Y + N++HRD++ +NIL+ + K+ADFGLARL E + + Sbjct: 131 LMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYR 190 Query: 433 APEAALYG-RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP 491 PE L R+T DVWS G +L EL TK + + + L+ + R PCP P Sbjct: 191 PPELLLGEERYTPAIDVWSCGCILGELFTK-KPIFQANLELAQLELISRLCGSPCPAVWP 249 Query: 492 ESLH-----------------------------DLMCQCWRKEPEERPTFEYLQAFLEDY 522 + + DL+ +P +R T E Q D+ Sbjct: 250 DVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAE--QTLQSDF 307 Query: 523 FTSTE---------PQYQPGENL 536 E P +Q L Sbjct: 308 LKDVELSKMAPPDLPHWQDCHEL 330 >2W4O-A nrPDB Length = 349 Score = 229 bits (585), Expect = 2e-60, Method: Composition-based stats. Identities = 70/288 (24%), Positives = 126/288 (43%), Gaps = 20/288 (6%) Query: 244 LTTVCPTSKPQTQGLAKDAW------EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VA 296 +++V ++ P T L D W + + +E +LG+G V+ GT + A Sbjct: 23 MSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYA 82 Query: 297 IKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKG 355 +K LK T+ + E V+ +L H +++L + + I +V E ++ G L D + Sbjct: 83 LKVLKK-TVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVE 141 Query: 356 ETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLAR 412 + Y D QI +AY+ VHRDL+ N+L + K+ADFGL++ Sbjct: 142 KG--YYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSK 199 Query: 413 LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR 472 ++E + + APE + + D+WS GI+ L Y ++ Sbjct: 200 IVE--HQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQ 257 Query: 473 EVLDQV---ERGYRMPCPPECPESLHDLMCQCWRKEPEERP-TFEYLQ 516 + ++ E + P E + DL+ + +P++R TF+ LQ Sbjct: 258 FMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQ 305 >3ZUT-A nrPDB Length = 362 Score = 229 bits (584), Expect = 2e-60, Method: Composition-based stats. Identities = 58/273 (21%), Positives = 107/273 (39%), Gaps = 17/273 (6%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324 + L +G G FG + + VA+K ++ G E +E + LRH Sbjct: 17 DSDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKIDENVKREIINHRSLRHPN 76 Query: 325 LVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 +V+ V+ + + IV EY S G L + + + Q+ SG++Y M Sbjct: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICN--AGRFSEDEARFFFQQLISGVSYCHAM 134 Query: 384 NYVHRDLRAANILVGENLV--CKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 HRDL+ N L+ + K+ FG ++ ++ + + APE L Sbjct: 135 QVCHRDLKLENTLLDGSPAPRLKICAFGYSK--SSVLHSQPKSTVGTPAYIAPEVLLKKE 192 Query: 442 FTIKS-DVWSFGILLTELTTKGRVPYPG----MVNREVLDQVER-GYRMPCPPECPESLH 495 + K DVWS G+ L + G P+ R+ + ++ Y +P Sbjct: 193 YDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 Query: 496 DLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEP 528 L+ + + +P +R + ++ ++F P Sbjct: 252 HLISRIFVADPAKRISIPEIRN--HEWFLKNLP 282 >6QAU-A nrPDB Length = 280 Score = 229 bits (584), Expect = 3e-60, Method: Composition-based stats. Identities = 70/274 (25%), Positives = 120/274 (43%), Gaps = 25/274 (9%) Query: 268 ESLRLEVK--LGQGCFGEVWMGTWNGTT--RVAIKTLKPGTMSPEAFL--QEAQVMKKLR 321 + +G G F V+ G T VAIK++ +S L +E +++K+L+ Sbjct: 9 GDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQ 68 Query: 322 HEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 HE +V LY V +++V EY + G L D+L+ + L + QIA+ M + Sbjct: 69 HENIVALYDVQELPNSVFLVMEYCNGGDLADYLQAKG--TLSEDTIRVFLHQIAAAMRIL 126 Query: 381 ERMNYVHRDLRAANILVG---------ENLVCKVADFGLARLIEDNEYTARQGAKFPIKW 431 +HRDL+ NIL+ + K+ADFG AR + N A + Sbjct: 127 HSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLC--GSPMY 184 Query: 432 TAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM--PCPPE 489 APE + + K+D+WS G ++ + G+ P+ +++ E+ + P E Sbjct: 185 MAPEVIMSQHYDAKADLWSIGTVIYQCLV-GKPPFQANSPQDLRMFYEKNRSLMPSIPRE 243 Query: 490 CPESLHDLMCQCWRKEPEERPTFEYL--QAFLED 521 L +L+ ++ ++R FE FLE Sbjct: 244 TSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQ 277 >4XBR-A nrPDB Length = 366 Score = 228 bits (582), Expect = 4e-60, Method: Composition-based stats. Identities = 58/268 (21%), Positives = 116/268 (43%), Gaps = 12/268 (4%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLK-PGTMSPEAFLQEAQVMKKLRHE 323 PR L +K+G+G G V + T + + VA+K + E E +M+ +HE Sbjct: 92 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE 151 Query: 324 KLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V++Y + + +++V E++ G+L D + T + Q+ + + ++ + Sbjct: 152 NVVEMYNSYLVGDELWVVMEFLEGGALTDIV---THTRMNEEQIAAVCLAVLQALSVLHA 208 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 +HRD+++ +IL+ + K++DFG + E R+ W APE + Sbjct: 209 QGVIHRDIKSDSILLTHDGRVKLSDFGFCAQV-SKEVPRRKSLVGTPYWMAPELISRLPY 267 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY--RMPCPPECPESLHDLMCQ 500 + D+WS GI++ E+ G PY + + + R+ + SL + + Sbjct: 268 GPEVDIWSLGIMVIEM-VDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDR 326 Query: 501 CWRKEPEERPTFEYLQAFLEDYFTSTEP 528 ++P +R T L + P Sbjct: 327 LLVRDPAQRATAAEL--LKHPFLAKAGP 352 >4JDH-A nrPDB Length = 346 Score = 228 bits (582), Expect = 4e-60, Method: Composition-based stats. Identities = 58/268 (21%), Positives = 116/268 (43%), Gaps = 12/268 (4%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLK-PGTMSPEAFLQEAQVMKKLRHE 323 PR L +K+G+G G V + T + + VA+K + E E +M+ +HE Sbjct: 72 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE 131 Query: 324 KLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V++Y + + +++V E++ G+L D + T + Q+ + + ++ + Sbjct: 132 NVVEMYNSYLVGDELWVVMEFLEGGALTDIV---THTRMNEEQIAAVCLAVLQALSVLHA 188 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 +HRD+++ +IL+ + K++DFG + E R+ W APE + Sbjct: 189 QGVIHRDIKSDSILLTHDGRVKLSDFGFCAQV-SKEVPRRKSLVGTPYWMAPELISRLPY 247 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY--RMPCPPECPESLHDLMCQ 500 + D+WS GI++ E+ G PY + + + R+ + SL + + Sbjct: 248 GPEVDIWSLGIMVIEM-VDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDR 306 Query: 501 CWRKEPEERPTFEYLQAFLEDYFTSTEP 528 ++P +R T L + P Sbjct: 307 LLVRDPAQRATAAEL--LKHPFLAKAGP 332 >2Q0N-A nrPDB Length = 301 Score = 228 bits (582), Expect = 4e-60, Method: Composition-based stats. Identities = 58/268 (21%), Positives = 116/268 (43%), Gaps = 12/268 (4%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLK-PGTMSPEAFLQEAQVMKKLRHE 323 PR L +K+G+G G V + T + + VA+K + E E +M+ +HE Sbjct: 27 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE 86 Query: 324 KLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V++Y + + +++V E++ G+L D + T + Q+ + + ++ + Sbjct: 87 NVVEMYNSYLVGDELWVVMEFLEGGALTDIV---THTRMNEEQIAAVCLAVLQALSVLHA 143 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 +HRD+++ +IL+ + K++DFG + E R+ W APE + Sbjct: 144 QGVIHRDIKSDSILLTHDGRVKLSDFGFCAQV-SKEVPRRKSLVGTPYWMAPELISRLPY 202 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY--RMPCPPECPESLHDLMCQ 500 + D+WS GI++ E+ G PY + + + R+ + SL + + Sbjct: 203 GPEVDIWSLGIMVIEM-VDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDR 261 Query: 501 CWRKEPEERPTFEYLQAFLEDYFTSTEP 528 ++P +R T L + P Sbjct: 262 LLVRDPAQRATAAEL--LKHPFLAKAGP 287 >2YAB-A nrPDB Length = 361 Score = 228 bits (582), Expect = 4e-60, Method: Composition-based stats. Identities = 64/290 (22%), Positives = 115/290 (39%), Gaps = 23/290 (7%) Query: 257 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGT-------MSPE 308 G+ + + + +LG G F V T A K +K + E Sbjct: 1 GMETFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCRE 60 Query: 309 AFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLV 367 +E +++++ H ++ L+ V + ++ E +S G L DFL + + L + Sbjct: 61 EIEREVSILRQVLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQK--ESLSEEEAT 118 Query: 368 DMAAQIASGMAYVERMNYVHRDLRAANILVGENL----VCKVADFGLARLIEDNEYTARQ 423 QI G+ Y+ H DL+ NI++ + K+ DFGLA IED + Sbjct: 119 SFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDG--VEFK 176 Query: 424 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV---ER 480 ++ APE Y +++D+WS G++ L + G P+ G +E L + Sbjct: 177 NIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLANITAVSY 235 Query: 481 GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 + + E D + + KE +R T + A + T + Q Sbjct: 236 DFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQE--ALRHPWITPVDTQQ 283 >4FIE-A nrPDB Length = 423 Score = 228 bits (582), Expect = 4e-60, Method: Composition-based stats. Identities = 58/268 (21%), Positives = 116/268 (43%), Gaps = 12/268 (4%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLK-PGTMSPEAFLQEAQVMKKLRHE 323 PR L +K+G+G G V + T + + VA+K + E E +M+ +HE Sbjct: 149 PRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHE 208 Query: 324 KLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V++Y + + +++V E++ G+L D + T + Q+ + + ++ + Sbjct: 209 NVVEMYNSYLVGDELWVVMEFLEGGALTDIV---THTRMNEEQIAAVCLAVLQALSVLHA 265 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 +HRD+++ +IL+ + K++DFG + E R+ W APE + Sbjct: 266 QGVIHRDIKSDSILLTHDGRVKLSDFGFCAQV-SKEVPRRKSLVGTPYWMAPELISRLPY 324 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY--RMPCPPECPESLHDLMCQ 500 + D+WS GI++ E+ G PY + + + R+ + SL + + Sbjct: 325 GPEVDIWSLGIMVIEM-VDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDR 383 Query: 501 CWRKEPEERPTFEYLQAFLEDYFTSTEP 528 ++P +R T L + P Sbjct: 384 LLVRDPAQRATAAEL--LKHPFLAKAGP 409 >3UC3-A nrPDB Length = 361 Score = 228 bits (581), Expect = 5e-60, Method: Composition-based stats. Identities = 58/273 (21%), Positives = 106/273 (38%), Gaps = 17/273 (6%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324 + +G G FG + T VA+K ++ G E +E + LRH Sbjct: 18 DSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAIDENVQREIINHRSLRHPN 77 Query: 325 LVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 +V+ V+ + + I+ EY S G L + + + Q+ SG++Y M Sbjct: 78 IVRFKEVILTPTHLAIIMEYASGGELYERI--CNAGRFSEDEARFFFQQLLSGVSYCHSM 135 Query: 384 NYVHRDLRAANILVGENLV--CKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 HRDL+ N L+ + K+ DFG ++ ++ + + APE L Sbjct: 136 QICHRDLKLENTLLDGSPAPRLKICDFGYSK--SSVLHSQPKSTVGTPAYIAPEVLLRQE 193 Query: 442 FTIK-SDVWSFGILLTELTTKGRVPYPG----MVNREVLDQVER-GYRMPCPPECPESLH 495 + K +DVWS G+ L + G P+ R+ + ++ Y +P Sbjct: 194 YDGKIADVWSCGVTLYVMLV-GAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECC 252 Query: 496 DLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEP 528 L+ + + +P R + ++ +F P Sbjct: 253 HLISRIFVADPATRISIPEIKT--HSWFLKNLP 283 >4BBM-A nrPDB Length = 331 Score = 228 bits (581), Expect = 5e-60, Method: Composition-based stats. Identities = 74/296 (25%), Positives = 119/296 (40%), Gaps = 42/296 (14%) Query: 267 RESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTL---KPGTMSPEAFLQEAQVMKKLRH 322 E +G+G +G V T R VAIK M + ++E +++K+LRH Sbjct: 24 MEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRH 83 Query: 323 EKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 E LV L V ++ Y+V E++ L D L + QI +G+ + Sbjct: 84 ENLVNLLEVCKKKKRWYLVFEFVDHTILDDL--ELFPNGLDYQVVQKYLFQIINGIGFCH 141 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG- 440 N +HRD++ NILV ++ V K+ DFG AR + + APE + Sbjct: 142 SHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEV-YDDEVATRWYRAPELLVGDV 200 Query: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE--------------------R 480 ++ DVW+ G L+TE+ G +PG + + L + Sbjct: 201 KYGKAVDVWAIGCLVTEMF-MGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNPVFA 259 Query: 481 GYRMP----------CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 G R+P P+ E + DL +C +P++RP L D+F Sbjct: 260 GVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLH--HDFFQMD 313 >1V0B-A nrPDB Length = 288 Score = 228 bits (581), Expect = 5e-60, Method: Composition-based stats. Identities = 66/285 (23%), Positives = 119/285 (41%), Gaps = 39/285 (13%) Query: 273 EVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMS---PEAFLQEAQVMKKLRHEKLVQLY 329 K+G+G +G V+ N A+K ++ P ++E ++K+L+H +V+LY Sbjct: 7 LEKIGEGTYGVVYKAQNNYGETFALKKIRLEKEDEGIPSTTIREISILKELKHSNIVKLY 66 Query: 330 AVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 V+ +++ + +V E++ + L L G L Q+ +G+AY +HR Sbjct: 67 DVIHTKKRLVLVFEHLDQ-DLKKLLDVCEG-GLESVTAKSFLLQLLNGIAYCHDRRVLHR 124 Query: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY-GRFTIKSD 447 DL+ N+L+ K+ADFGLAR + + AP+ + +++ D Sbjct: 125 DLKPQNLLINREGELKIADFGLARAF-GIPVRKYTHEVVTLWYRAPDVLMGSKKYSTTID 183 Query: 448 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP---------------- 491 +WS G + E+ G +PG+ + L ++ R P P Sbjct: 184 IWSVGCIFAEM-VNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTELPKYDPNFTVYE 242 Query: 492 ------------ESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFT 524 ES DL+ + + +P +R T + QA YF Sbjct: 243 PLPWESFLKGLDESGIDLLSKMLKLDPNQRITAK--QALEHAYFK 285 >3TXO-A nrPDB Length = 353 Score = 228 bits (581), Expect = 5e-60, Method: Composition-based stats. Identities = 56/249 (22%), Positives = 105/249 (42%), Gaps = 12/249 (4%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTM----SPEAFLQEAQVMKKLR- 321 ++ LG+G FG+V + T A+K LK + E + E +++ R Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN 82 Query: 322 HEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 H L QL+ + + ++ V E+++ G L+ ++ + + AA+I S + ++ Sbjct: 83 HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQK--SRRFDEARARFYAAEIISALMFL 140 Query: 381 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 440 ++RDL+ N+L+ CK+ADFG+ + N T P + APE Sbjct: 141 HDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTP-DYIAPEILQEM 199 Query: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQ 500 + D W+ G+LL E+ G P+ ++ + + + P E ++ Sbjct: 200 LYGPAVDWWAMGVLLYEMLC-GHAPFEAENEDDLFEAILN-DEVVYPTWLHEDATGILKS 257 Query: 501 CWRKEPEER 509 K P R Sbjct: 258 FMTKNPTMR 266 >5J5T-A nrPDB Length = 370 Score = 228 bits (581), Expect = 6e-60, Method: Composition-based stats. Identities = 65/261 (24%), Positives = 109/261 (41%), Gaps = 12/261 (4%) Query: 267 RESLRLEVKLGQGCFGEVWMGTWNGTTRVA-IKTLKPGT-MSPEAFLQEAQVMKKLRHEK 324 +E L ++G G +G+V+ T +A IK +K QE +MK +H Sbjct: 3 QEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPN 62 Query: 325 LVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 +V + + + ++I E+ GSL D L Q+ ++ + G+ Y+ Sbjct: 63 IVAYFGSYLRRDKLWICMEFCGGGSLQDIYH--VTGPLSELQIAYVSRETLQGLYYLHSK 120 Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA---LYG 440 +HRD++ ANIL+ +N K+ADFG++ I R+ W APE A G Sbjct: 121 GKMHRDIKGANILLTDNGHVKLADFGVSAQIT-ATIAKRKAFIGTPYWMAPEVAAVERKG 179 Query: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE---CPESLHDL 497 + D+W+ GI EL + R + + ++ P + S H Sbjct: 180 GYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHF 239 Query: 498 MCQCWRKEPEERPTFEYLQAF 518 + K P++RPT E L Sbjct: 240 VKMALTKNPKKRPTAEKLLQH 260 >2XNP-A nrPDB Length = 279 Score = 228 bits (581), Expect = 6e-60, Method: Composition-based stats. Identities = 59/264 (22%), Positives = 114/264 (43%), Gaps = 16/264 (6%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRVAI-KTLKPGTM---SPEAFLQEAQVMKKLRHE 323 E + +G G +G ++ + K L G+M + + E ++++L+H Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65 Query: 324 KLVQLYAVV---SEEPIYIVTEYMSKGSLLDFLKG--ETGKYLRLPQLVDMAAQIASGMA 378 +V+ Y + + +YIV EY G L + + +YL ++ + Q+ + Sbjct: 66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALK 125 Query: 379 YVERMN-----YVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 433 R + +HRDL+ AN+ + K+ DFGLAR++ + A+ P + + Sbjct: 126 ECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTP-YYMS 184 Query: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES 493 PE + KSD+WS G LL EL P+ +E+ ++ G P + Sbjct: 185 PEQMNRMSYNEKSDIWSLGCLLYELCAL-MPPFTAFSQKELAGKIREGKFRRIPYRYSDE 243 Query: 494 LHDLMCQCWRKEPEERPTFEYLQA 517 L++++ + + RP+ E + Sbjct: 244 LNEIITRMLNLKDYHRPSVEEILE 267 >5XZW-A nrPDB Length = 471 Score = 227 bits (580), Expect = 6e-60, Method: Composition-based stats. Identities = 62/265 (23%), Positives = 118/265 (44%), Gaps = 27/265 (10%) Query: 272 LEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTM--SPEAFLQEAQVMKKLRHEKLVQL 328 ++ +GQG F V T + A+K + + + + +E +V++KL H ++V+L Sbjct: 200 IDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRL 259 Query: 329 YAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 + E Y+V E++S G L+DF+ + +++ QI + + Y+ M H Sbjct: 260 KGFYEDTESYYMVMEFVSGGDLMDFVAAHG--AVGEDAGREISRQILTAIKYIHSMGISH 317 Query: 388 RDLRAANILVGENL--VCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG----- 440 RDL+ NIL+ ++ + K+ DFGLA++ + + + + + APE Sbjct: 318 RDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSF--MKTFCGTLAYVAPEVIRGKDTSVS 375 Query: 441 --------RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE--- 489 ++ D+WS G L+ + T G +P+ G ++ Q+ RG P + Sbjct: 376 PDEYEERNEYSSLVDMWSMGCLVYVILT-GHLPFSGSTQDQLYKQIGRGSYHEGPLKDFR 434 Query: 490 CPESLHDLMCQCWRKEPEERPTFEY 514 E D + + +P R T Sbjct: 435 ISEEARDFIDSLLQVDPNNRSTAAK 459 >5X3F-B nrPDB Length = 393 Score = 227 bits (580), Expect = 7e-60, Method: Composition-based stats. Identities = 55/260 (21%), Positives = 108/260 (41%), Gaps = 14/260 (5%) Query: 256 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSP----EAF 310 + + LG G FG V + + A+K L + E Sbjct: 72 KWETPSQNTAQLDQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQIEHT 131 Query: 311 LQEAQVMKKLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDM 369 L E ++++ + LV+L ++ +Y+V EY++ G + L+ P Sbjct: 132 LNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVAGGEMFSHLRRIGR--FSEPHARFY 189 Query: 370 AAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPI 429 AAQI Y+ ++ ++RDL+ N+L+ + +V DFG A+ ++ +T Sbjct: 190 AAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL----CGTP 245 Query: 430 KWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE 489 ++ APE L + D W+ G+L+ E+ G P+ ++ +++ G ++ P Sbjct: 246 EYLAPEIILSKGYNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSH 303 Query: 490 CPESLHDLMCQCWRKEPEER 509 L DL+ + + +R Sbjct: 304 FSSDLKDLLRNLLQVDLTKR 323 >4WB7-A nrPDB Length = 405 Score = 227 bits (579), Expect = 8e-60, Method: Composition-based stats. Identities = 56/248 (22%), Positives = 106/248 (42%), Gaps = 14/248 (5%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSP----EAFLQEAQVMKKLRH 322 + LG G FG V + T A+K L + E L E ++++ + Sbjct: 96 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNF 155 Query: 323 EKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 LV+L ++ +Y+V EY+ G + L+ P AAQI Y+ Sbjct: 156 PFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGR--FSEPHARFYAAQIVLTFEYLH 213 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 ++ ++RDL+ N+L+ + +V DFG A+ ++ +T ++ APE L Sbjct: 214 SLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTL----CGTPEYLAPEIILSKG 269 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 501 + D W+ G+L+ E+ G P+ ++ +++ G ++ P L DL+ Sbjct: 270 YNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNL 327 Query: 502 WRKEPEER 509 + + +R Sbjct: 328 LQVDLTKR 335 >5YV8-A nrPDB Length = 298 Score = 227 bits (579), Expect = 8e-60, Method: Composition-based stats. Identities = 68/296 (22%), Positives = 126/296 (42%), Gaps = 42/296 (14%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTW-NGTTRVAIKTLKPGTMSP---------------- 307 + L+ ++G+G +G V + N T A+K L + Sbjct: 10 VQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPA 69 Query: 308 -----------EAFLQEAQVMKKLRHEKLVQLYAVVSE---EPIYIVTEYMSKGSLLDFL 353 E QE ++KKL H +V+L V+ + + +Y+V E +++G +++ Sbjct: 70 PGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEV- 128 Query: 354 KGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARL 413 T K L Q + G+ Y+ +HRD++ +N+LVGE+ K+ADFG++ Sbjct: 129 --PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNE 186 Query: 414 IEDNEYTARQGAKFPIKWTAPEAALYGR--FTIKS-DVWSFGILLTELTTKGRVPYPGMV 470 + ++ + APE+ R F+ K+ DVW+ G+ L G+ P+ Sbjct: 187 FKGSD-ALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLY-CFVFGQCPFMDER 244 Query: 471 NREVLDQVE-RGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTS 525 + +++ + P P+ E L DL+ + K PE R ++ L + T Sbjct: 245 IMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIK--LHPWVTR 298 >3UDB-A nrPDB Length = 317 Score = 227 bits (579), Expect = 8e-60, Method: Composition-based stats. Identities = 61/273 (22%), Positives = 109/273 (39%), Gaps = 17/273 (6%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324 + L +G G FG + VA+K ++ G E +E + LRH Sbjct: 17 DSDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKIDENVKREIINHRSLRHPN 76 Query: 325 LVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 +V+ V+ + + IV EY S G L + + + Q+ SG++Y M Sbjct: 77 IVRFKEVILTPTHLAIVMEYASGGELFERICN--AGRFSEDEARFFFQQLISGVSYAHAM 134 Query: 384 NYVHRDLRAANILVGENLV--CKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 HRDL+ N L+ + K+ADFG ++ ++ + A + APE L Sbjct: 135 QVAHRDLKLENTLLDGSPAPRLKIADFGYSK--ASVLHSQPKSAVGTPAYIAPEVLLKKE 192 Query: 442 FTIKS-DVWSFGILLTELTTKGRVPYPG----MVNREVLDQVER-GYRMPCPPECPESLH 495 + K DVWS G+ L + G P+ R+ + ++ Y +P Sbjct: 193 YDGKVADVWSCGVTLYVMLV-GAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPECR 251 Query: 496 DLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEP 528 L+ + + +P +R + ++ ++F P Sbjct: 252 HLISRIFVADPAKRISIPEIRN--HEWFLKNLP 282 >2A27-A nrPDB Length = 321 Score = 227 bits (579), Expect = 1e-59, Method: Composition-based stats. Identities = 65/290 (22%), Positives = 116/290 (40%), Gaps = 23/290 (7%) Query: 257 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGT-------MSPE 308 G+ + + + +LG G F V T A K +K +S E Sbjct: 1 GMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSRE 60 Query: 309 AFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLV 367 +E +++++ H ++ L+ V + ++ E +S G L DFL + + L + Sbjct: 61 EIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQK--ESLSEEEAT 118 Query: 368 DMAAQIASGMAYVERMNYVHRDLRAANILVGENL----VCKVADFGLARLIEDNEYTARQ 423 QI G+ Y+ H DL+ NI++ + K+ DFGLA IED + Sbjct: 119 SFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDG--VEFK 176 Query: 424 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV---ER 480 ++ APE Y +++D+WS G++ L + G P+ G +E L + Sbjct: 177 NIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLANITAVSY 235 Query: 481 GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 + + E D + + KE +R T + A + T + Q Sbjct: 236 DFDEEFFSQTSELAKDFIRKLLVKETRKRLTIQE--ALRHPWITPVDNQQ 283 >5N23-A nrPDB Length = 352 Score = 227 bits (578), Expect = 1e-59, Method: Composition-based stats. Identities = 57/248 (22%), Positives = 103/248 (41%), Gaps = 13/248 (5%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSP----EAFLQEAQVMKKLRH 322 + LG G FG V + T A+K L + E L E ++ + + Sbjct: 42 DQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNF 101 Query: 323 EKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 LV+L ++ +Y+V EY G + L+ P AAQI Y+ Sbjct: 102 PFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGR--FSEPHARFYAAQIVLTFEYLH 159 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 ++ ++RDL+ N+L+ + KVADFG A+ ++ ++ APE L Sbjct: 160 SLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGR---TPWTLCGTPEYLAPEIILSKG 216 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 501 + D W+ G+L+ E+ G P+ ++ +++ G ++ P L DL+ Sbjct: 217 YNKAVDWWALGVLIYEMAA-GYPPFFADQPIQIYEKIVSG-KVRFPSHFSSDLKDLLRNL 274 Query: 502 WRKEPEER 509 + + +R Sbjct: 275 LQVDLTKR 282 >4TNB-A nrPDB Length = 590 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 67/333 (20%), Positives = 132/333 (39%), Gaps = 18/333 (5%) Query: 207 IRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIP 266 + + + + F++ Q V Y + G Q + + Sbjct: 126 VSQTEEKLLQKPCKELFSACAQSVHEYLR---GEPFHEYLDSMFFDRFLQWKWLERQPVT 182 Query: 267 RESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEA----FLQEAQVMKKLR 321 + + R LG+G FGEV T + A K L+ + L E Q+++K+ Sbjct: 183 KNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVN 242 Query: 322 HEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 + +V L YA +++ + +V M+ G L + + + AA+I G+ + Sbjct: 243 SQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDL 302 Query: 381 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 440 N V+RDL+ NIL+ + +++D GLA I + + +G + + APE Sbjct: 303 HHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGD--LIRGRVGTVGYMAPEVLNNQ 360 Query: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY---RMPCPPECPESLHDL 497 R+ + D W G L+ E+ +G+ P+ G + ++V+R + E + Sbjct: 361 RYGLSPDYWGLGCLIYEMI-EGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSI 419 Query: 498 MCQCWRKEPEERPTFEYLQA---FLEDYFTSTE 527 K+ ++R + +A +F + Sbjct: 420 CKMLLTKDAKQRLGCQEEEAAEVKRHPFFRNMN 452 >4KS7-A nrPDB Length = 292 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 61/261 (23%), Positives = 117/261 (44%), Gaps = 16/261 (6%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLK-PGTMSPEAFLQEAQVMKKLRHE 323 PR L VK+G+G G V + + R VA+K + E E +M+ +H Sbjct: 21 PRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHF 80 Query: 324 KLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V++Y + + E ++++ E++ G+L D + + L Q+ + + +AY+ Sbjct: 81 NVVEMYKSYLVGEELWVLMEFLQGGALTDIV---SQVRLNEEQIATVCEAVLQALAYLHA 137 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 +HRD+++ +IL+ + K++DFG I + R+ W APE + Sbjct: 138 QGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKD-VPKRKSLVGTPYWMAPEVISRSLY 196 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP-----ECPESLHDL 497 + D+WS GI++ E+ G PY + + ++ P P + L D Sbjct: 197 ATEVDIWSLGIMVIEM-VDGEPPYFSDSPVQAMKRLR---DSPPPKLKNSHKVSPVLRDF 252 Query: 498 MCQCWRKEPEERPTFEYLQAF 518 + + ++P+ER T + L Sbjct: 253 LERMLVRDPQERATAQELLDH 273 >1VZO-A nrPDB Length = 355 Score = 226 bits (577), Expect = 1e-59, Method: Composition-based stats. Identities = 68/288 (23%), Positives = 126/288 (43%), Gaps = 26/288 (9%) Query: 254 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGT----WNGTTRVAIKTLKPGTMSP-- 307 +T L A ++ E+ L LG G +G+V++ + A+K LK T+ Sbjct: 40 RTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKA 99 Query: 308 ---EAFLQEAQVMKKLR-HEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLR 362 E E QV++ +R LV L YA +E ++++ +Y++ G L L + Sbjct: 100 KTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQR--ERFT 157 Query: 363 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTAR 422 ++ +I + ++ ++ ++RD++ NIL+ N + DFGL++ +E Sbjct: 158 EHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERA 217 Query: 423 QGAKFPIKWTAPEAALYG--RFTIKSDVWSFGILLTELTTKGRVPY--PGMVNR--EVLD 476 I++ AP+ G D WS G+L+ EL T G P+ G N E+ Sbjct: 218 YDFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLT-GASPFTVDGEKNSQAEISR 276 Query: 477 QVERGYRMPCPPECPESLHDLMCQCWRKEPEERP-----TFEYLQAFL 519 ++ + P P E DL+ + K+P++R + ++ L Sbjct: 277 RILKS-EPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHL 323 >3HNG-A nrPDB Length = 360 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 94/345 (27%), Positives = 145/345 (42%), Gaps = 78/345 (22%) Query: 257 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR------VAIKTLKPGTMSPE-- 308 WE RE L+L LG+G FG+V + G + VA+K LK G + E Sbjct: 16 PYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYK 75 Query: 309 AFLQEAQVMKKL-RHEK-----------------LVQL--YA------------VVSEEP 336 A + E +++ + H +V+ Y + Sbjct: 76 ALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKD 135 Query: 337 IYIVTE--------------------------YMSKG-----SLLDFLKGETG-----KY 360 + E + S G SL D + E + Sbjct: 136 AALHMEPKKEKMEPGLEQGKKPRLDSVTSSESFASSGFQEDKSLSDVEEEEDSDGFYKEP 195 Query: 361 LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDN-EY 419 + + L+ + Q+A GM ++ +HRDL A NIL+ EN V K+ DFGLAR I N +Y Sbjct: 196 ITMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDY 255 Query: 420 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMV-NREVLDQV 478 + + P+KW APE+ ++ KSDVWS+G+LL E+ + G PYPG+ + + ++ Sbjct: 256 VRKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRL 315 Query: 479 ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 G RM P ++ +M CW ++P+ERP F L L D Sbjct: 316 REGMRMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLGDLL 360 >1ZWS-A nrPDB Length = 288 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 65/290 (22%), Positives = 115/290 (39%), Gaps = 23/290 (7%) Query: 257 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGT-------MSPE 308 G+ + + + +LG G F V T A K +K +S E Sbjct: 1 GMEPFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSRE 60 Query: 309 AFLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLV 367 +E +++++ H ++ L+ V + ++ E +S G L DFL + + L + Sbjct: 61 EIEREVSILRQVLHHNVITLHDVYENRTDVVLILELVSGGELFDFLAQK--ESLSEEEAT 118 Query: 368 DMAAQIASGMAYVERMNYVHRDLRAANILVGENL----VCKVADFGLARLIEDNEYTARQ 423 QI G+ Y+ H DL+ NI++ + K+ DFGLA IED + Sbjct: 119 SFIKQILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDG--VEFK 176 Query: 424 GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV---ER 480 ++ APE Y +++D+WS G++ L + G P+ G +E L + Sbjct: 177 NIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLANITSVSY 235 Query: 481 GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 + E D + + KE +R T + A + T + Q Sbjct: 236 DFDEEFFSHTSELAKDFIRKLLVKETRKRLTIQE--ALRHPWITPVDNQQ 283 >2YCR-A nrPDB Length = 323 Score = 226 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 65/277 (23%), Positives = 113/277 (40%), Gaps = 27/277 (9%) Query: 267 RESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQ---------EAQV 316 R+ + LG G GEV + T +VAIK + + + + E ++ Sbjct: 9 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEI 68 Query: 317 MKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 +KKL H ++++ E YIV E M G L D K K L+ Q+ Sbjct: 69 LKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFD--KVVGNKRLKEATCKLYFYQMLLA 126 Query: 377 MAYVERMNYVHRDLRAANILVG---ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 433 + Y+ +HRDL+ N+L+ E+ + K+ DFG ++++ E + + + A Sbjct: 127 VQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL--GETSLMRTLCGTPTYLA 184 Query: 434 PEAAL---YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR-EVLDQVERG---YRMPC 486 PE + + D WS G++L + G P+ + + DQ+ G + Sbjct: 185 PEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEHRTQVSLKDQITSGKYNFIPEV 243 Query: 487 PPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 E E DL+ + +P+ R T E A + Sbjct: 244 WAEVSEKALDLVKKLLVVDPKARFTTEE--ALRHPWL 278 >4NEU-A nrPDB Length = 333 Score = 226 bits (575), Expect = 3e-59, Method: Composition-based stats. Identities = 81/294 (27%), Positives = 132/294 (44%), Gaps = 23/294 (7%) Query: 258 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGT---MSPEAFLQEA 314 ++ + ++ +L G FG+V + + +KT+ G EA L+EA Sbjct: 14 MSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEA 73 Query: 315 QVMKKLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373 ++M +LRH ++V+L V+ EE Y +V EYM KG+L+ LK E L + + +I Sbjct: 74 KMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVK--GRIILEI 131 Query: 374 ASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--------EDNEYTARQGA 425 GM Y+ +H+DL+ NILV + K+AD GLA E NE G Sbjct: 132 IEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGT 191 Query: 426 ----KFPIKWTAPEAAL--YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE 479 + + APE + T KSDV+SF ++L + + ++++ ++ Sbjct: 192 AKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIK 251 Query: 480 RGYRMPCPP---ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 G R CP + LM CW PE RPTF ++ ++ S + Sbjct: 252 SGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEES 305 >4TPT-A nrPDB Length = 303 Score = 225 bits (574), Expect = 3e-59, Method: Composition-based stats. Identities = 83/279 (29%), Positives = 124/279 (44%), Gaps = 29/279 (10%) Query: 269 SLRLEVKLGQGCFGEVWMGTWNGTTRVAI-K-TLKPGTMSPEAFLQEAQVMKKLRHEKLV 326 L LG+G FG+ T T +V + K ++ + + FL E +VM+ L H ++ Sbjct: 1 DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVL 60 Query: 327 QLYAV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 + V ++ + ++TEY+ G+L DFL+ Q V A IASGMAY+ M Sbjct: 61 KFIGVLYKDKKLNLLTEYIEGGTLKDFLRS--MDPFPWQQKVRFAKGIASGMAYLHSMCI 118 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIED-------------------NEYTARQGAK 426 +HRDL + N L+ + VADFGL+RLI + N+ R Sbjct: 119 IHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKRYTVV 178 Query: 427 FPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRV---PYPGMVNREVLDQVERGYR 483 W APE + D++SFGI+L E+ G+V P + V+ + Sbjct: 179 GNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII--GQVYADPDCLPRTLDFGLNVKLFWE 236 Query: 484 MPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 P +CP + L C R EPE RP F L+ E Sbjct: 237 KFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDSFEAL 275 >3TKU-A nrPDB Length = 433 Score = 225 bits (574), Expect = 4e-59, Method: Composition-based stats. Identities = 70/292 (23%), Positives = 120/292 (41%), Gaps = 22/292 (7%) Query: 229 LVAYYSKHADGLCHRLTTVCPT---SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVW 285 LV Y++ + R V +KP TQ + + ++ RE + +G+G FGEV Sbjct: 50 LVCLYTECSHSALRRDKYVAEFLEWAKPFTQLVKE--MQLHREDFEIIKVIGRGAFGEVA 107 Query: 286 MGTWNGTTRV-AIKTLKPGTMSPEA----FLQEAQVMKKLRHEKLVQL-YAVVSEEPIYI 339 + T R+ A+K L M A F +E V+ + + L YA E +Y+ Sbjct: 108 VVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQWITALHYAFQDENHLYL 167 Query: 340 VTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE 399 V +Y G LL L K L ++ + + +++YVHRD++ N+L+ Sbjct: 168 VMDYYVGGDLLTLLSKFEDK-LPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDV 226 Query: 400 NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL-----YGRFTIKSDVWSFGIL 454 N ++ADFG + D+ A + +PE G++ + D WS G+ Sbjct: 227 NGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVC 286 Query: 455 LTELTTKGRVPYPGMVNREVLDQVERG-YRMPCPP---ECPESLHDLMCQCW 502 + E+ G P+ E ++ R P + E DL+ + Sbjct: 287 MYEML-YGETPFYAESLVETYGKIMNHEERFQFPSHVTDVSEEAKDLIQRLI 337 >6CQF-A nrPDB Length = 297 Score = 224 bits (572), Expect = 5e-59, Method: Composition-based stats. Identities = 66/262 (25%), Positives = 113/262 (43%), Gaps = 12/262 (4%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLK-PGTMSPEAFLQEAQVMKKLRHE 323 PR+ L +LG G +GEV+ + VA+K +K +E ++K RH Sbjct: 14 PRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQKEILILKTCRHA 73 Query: 324 KLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V + + + ++I E+ GSL D + L Q+ + ++ G+AY+ Sbjct: 74 NIVAYHGSYLWLQKLWICMEFCGAGSLQDIY--QVTGSLSELQISYVCREVLQGLAYLHS 131 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPE---AALY 439 +HRD++ ANIL+ + ++ADFG++ I R W APE AL Sbjct: 132 QKKIHRDIKGANILINDAGEVRLADFGISAQI-GATLARRLAFIGTPYWMAPEVAAVALK 190 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE---CPESLHD 496 G + D+WS GI EL + R + + GY+ P E + H+ Sbjct: 191 GGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHN 250 Query: 497 LMCQCWRKEPEERPTFEYLQAF 518 + K P++RP+ + + Sbjct: 251 FIKVTLTKSPKKRPSATKMLSH 272 >5JZN-A nrPDB Length = 280 Score = 224 bits (572), Expect = 6e-59, Method: Composition-based stats. Identities = 62/283 (21%), Positives = 119/283 (42%), Gaps = 25/283 (8%) Query: 256 QGLAKDAWEIP---RESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFL 311 + ++++ ++IP E ++ +G G F V T R A+K +K + + Sbjct: 4 EEVSEEGFQIPATITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHM 63 Query: 312 --QEAQVMKKLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD 368 E ++++++H +V L + +Y+V E + G L D + Sbjct: 64 IQNEVSILRRVKHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITS--TNKYTERDASG 121 Query: 369 MAAQIASGMAYVERMNYVHRDLRAANILV----GENLVCKVADFGLARLIEDNEYTARQG 424 M +AS + Y+ +N VHRD++ N+LV + K+ DFGLA +++ YT Sbjct: 122 MLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYT---- 177 Query: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYP--GMVNREVLDQVERG- 481 + APE + +K D+W+ G++ L G P+ G + DQ+ G Sbjct: 178 VCGTPTYVAPEIIAETGYGLKVDIWAAGVITYILLC-GFPPFRGSGDDQEVLFDQILMGQ 236 Query: 482 --YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 + P +S +L+ + ++R F +Q + Sbjct: 237 VDFPSPYWDNVSDSAKELITMMLLVDVDQR--FSAVQVLEHPW 277 >4B8L-A nrPDB Length = 286 Score = 224 bits (572), Expect = 6e-59, Method: Composition-based stats. Identities = 55/276 (19%), Positives = 107/276 (38%), Gaps = 15/276 (5%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPE----AFLQEAQVMK 318 + + + LG+G FG V++ + A+K L + E +E ++ Sbjct: 11 KFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQS 70 Query: 319 KLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 LRH ++++Y + IY++ E+ +G L L+ + ++A + Sbjct: 71 HLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGR--FDEQRSATFMEELADAL 128 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 437 Y +HRD++ N+L+G K+ADFG + R+ + + PE Sbjct: 129 HYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPS---LRRRTMCGTLDYLPPEMI 185 Query: 438 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDL 497 K D+W G+L E G P+ + E ++ + PP + DL Sbjct: 186 EGKTHDEKVDLWCAGVLCYEFLV-GMPPFDSPSHTETHRRIVN-VDLKFPPFLSDGSKDL 243 Query: 498 MCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPG 533 + + R P +R + + + + + PG Sbjct: 244 ISKLLRYHPPQRLPLKGVME--HPWVKANSRRVLPG 277 >1CM8-A nrPDB Length = 367 Score = 224 bits (571), Expect = 7e-59, Method: Composition-based stats. Identities = 80/334 (23%), Positives = 133/334 (39%), Gaps = 55/334 (16%) Query: 243 RLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLK 301 + S Q + K AWE+ R R +G G +G V T +VAIK L Sbjct: 1 MSSPPPARSGFYRQEVTKTAWEV-RAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLY 59 Query: 302 P---GTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-------PIYIVTEYMSKGSLLD 351 + + +E +++K +RHE ++ L V + + Y+V +M L Sbjct: 60 RPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFM-GTDLGK 118 Query: 352 FLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLA 411 +K E L ++ + Q+ G+ Y+ +HRDL+ N+ V E+ K+ DFGLA Sbjct: 119 LMKHEK---LGEDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLA 175 Query: 412 RLIEDNEYTARQGAKFPIKWTAPEAALY-GRFTIKSDVWSFGILLTELTTKGRVPYPGMV 470 R D+E T ++ + APE L R+T D+WS G ++ E+ T G+ + G Sbjct: 176 RQ-ADSEMTGYVVTRW---YRAPEVILNWMRYTQTVDIWSVGCIMAEMIT-GKTLFKGSD 230 Query: 471 NREVLDQVERGYRMPCPPEC----PESLHDLMC--------------------------Q 500 + + L ++ + P + + M + Sbjct: 231 HLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEK 290 Query: 501 CWRKEPEERPTF-EYL-QAFLEDY-FTSTEPQYQ 531 + E+R T E L + E T EPQ Q Sbjct: 291 MLVLDAEQRVTAGEALAHPYFESLHDTEDEPQVQ 324 >3GUB-A nrPDB Length = 295 Score = 224 bits (571), Expect = 7e-59, Method: Composition-based stats. Identities = 62/289 (21%), Positives = 119/289 (41%), Gaps = 23/289 (7%) Query: 258 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGT-------MSPEA 309 + E + +LG G F V T + A K +K +S E Sbjct: 1 MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSRED 60 Query: 310 FLQEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD 368 +E ++K+++H ++ L+ V + + ++ E ++ G L DFL + + L + + Sbjct: 61 IEREVSILKEIQHPNVITLHEVYENKTDVILIGELVAGGELFDFLAEK--ESLTEEEATE 118 Query: 369 MAAQIASGMAYVERMNYVHRDLRAANILVGENLV----CKVADFGLARLIEDNEYTARQG 424 QI +G+ Y+ + H DL+ NI++ + V K+ DFGLA I+ + Sbjct: 119 FLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFG--NEFKN 176 Query: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQ---VERG 481 ++ APE Y +++D+WS G++ L + G P+ G +E L V Sbjct: 177 IFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLS-GASPFLGDTKQETLANVSAVNYE 235 Query: 482 YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 + D + + K+P++R T + + + + Q Sbjct: 236 FEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQD--SLQHPWIKPKDTQQ 282 >4AU8-A nrPDB Length = 296 Score = 224 bits (571), Expect = 7e-59, Method: Composition-based stats. Identities = 64/291 (21%), Positives = 117/291 (40%), Gaps = 39/291 (13%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMS---PEAFLQEAQVMKKLRHE 323 + K+G+G +G V+ T VA+K ++ P + L+E ++K+L+H+ Sbjct: 6 QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKHK 65 Query: 324 KLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V+L+ V+ ++ + +V E+ + L + G L + Q+ G+ + Sbjct: 66 NIVRLHDVLHSDKKLTLVFEFCDQ-DLKKYFDSCNGD-LDPEIVKSFLFQLLKGLGFCHS 123 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR- 441 N +HRDL+ N+L+ N K+ADFGLAR + + P+ + Sbjct: 124 RNVLHRDLKPQNLLINRNGELKLADFGLARAF-GIPVRCYSAEVVTLWYRPPDVLFGAKL 182 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLH------ 495 ++ D+WS G + EL GR +PG + L ++ R P + P Sbjct: 183 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP 242 Query: 496 ----------------------DLMCQCWRKEPEERPTFEYLQAFLEDYFT 524 DL+ + P +R + E A YF+ Sbjct: 243 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEE--ALQHPYFS 291 >4AGU-A nrPDB Length = 311 Score = 224 bits (571), Expect = 8e-59, Method: Composition-based stats. Identities = 70/312 (22%), Positives = 124/312 (39%), Gaps = 45/312 (14%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP---EAFLQEAQVMKKLR 321 E K+G+G +G V+ T + VAIK P + L+E +++K+L+ Sbjct: 1 MMEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLK 60 Query: 322 HEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 H LV L V + +++V EY L + + + G + + + Q + + Sbjct: 61 HPNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRG--VPEHLVKSITWQTLQAVNFC 118 Query: 381 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 440 + N +HRD++ NIL+ ++ V K+ DFG ARL+ + +PE + Sbjct: 119 HKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDY-YDDEVATRWYRSPELLVGD 177 Query: 441 -RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER------------------- 480 ++ DVW+ G + EL + G +PG + + L + + Sbjct: 178 TQYGPPVDVWAIGCVFAELLS-GVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYF 236 Query: 481 -GYRMPCP----------PECPESLHDLMCQCWRKEPEERPTFEYLQAF-----LEDYFT 524 G ++P P P L+ C +P ER T E L + + Sbjct: 237 SGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIREIED 296 Query: 525 STEPQYQPGENL 536 + +P ENL Sbjct: 297 LAKEHDKPAENL 308 >3KN6-A nrPDB Length = 325 Score = 223 bits (569), Expect = 1e-58, Method: Composition-based stats. Identities = 59/280 (21%), Positives = 120/280 (42%), Gaps = 25/280 (8%) Query: 273 EVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLR-HEKLVQLYA 330 + LG+G F + + A+K + +E +K H +V+L+ Sbjct: 16 DKPLGEGSFSICRKCVHKKSNQAFAVKIISK--RMEANTQKEITALKLCEGHPNIVKLHE 73 Query: 331 VVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 V ++ ++V E ++ G L + +K + K+ + + ++ S ++++ + VHRD Sbjct: 74 VFHDQLHTFLVMELLNGGELFERIKKK--KHFSETEASYIMRKLVSAVSHMHDVGVVHRD 131 Query: 390 LRAANILV---GENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKS 446 L+ N+L +NL K+ DFG ARL + + F + + APE + Sbjct: 132 LKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPC-FTLHYAAPELLNQNGYDESC 190 Query: 447 DVWSFGILLTELTTKGRVPYPGMVNR-------EVLDQVERG---YRMPCPPECPESLHD 496 D+WS G++L + + G+VP+ E++ ++++G + + D Sbjct: 191 DLWSLGVILYTMLS-GQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWKNVSQEAKD 249 Query: 497 LMCQCWRKEPEERPTFEYLQ--AFLEDYFT-STEPQYQPG 533 L+ +P +R L+ +L+D S+ P P Sbjct: 250 LIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPD 289 >1U5R-A nrPDB Length = 348 Score = 223 bits (568), Expect = 2e-58, Method: Composition-based stats. Identities = 71/264 (26%), Positives = 112/264 (42%), Gaps = 18/264 (6%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTW-NGTTRVAIKTL----KPGTMSPEAFLQEAQVMKKL 320 P + ++G G FG V+ + VAIK + K + ++E + ++KL Sbjct: 52 PEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKL 111 Query: 321 RHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 RH +Q E ++V EY GS D L+ K L+ ++ + G+AY Sbjct: 112 RHPNTIQYRGCYLREHTAWLVMEYC-LGSASDLLEVHK-KPLQEVEIAAVTHGALQGLAY 169 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL- 438 + N +HRD++A NIL+ E + K+ DFG A ++ W APE L Sbjct: 170 LHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN-----SFVGTPYWMAPEVILA 224 Query: 439 --YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP-CPPECPESLH 495 G++ K DVWS GI EL + + P M L + + E Sbjct: 225 MDEGQYDGKVDVWSLGITCIELAER-KPPLFNMNAMSALYHIAQNESPALQSGHWSEYFR 283 Query: 496 DLMCQCWRKEPEERPTFEYLQAFL 519 + + C +K P++RPT E L Sbjct: 284 NFVDSCLQKIPQDRPTSEVLLKHR 307 >2GCD-A nrPDB Length = 309 Score = 222 bits (567), Expect = 2e-58, Method: Composition-based stats. Identities = 71/264 (26%), Positives = 112/264 (42%), Gaps = 18/264 (6%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTW-NGTTRVAIKTL----KPGTMSPEAFLQEAQVMKKL 320 P + ++G G FG V+ + VAIK + K + ++E + ++KL Sbjct: 13 PEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIKEVRFLQKL 72 Query: 321 RHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 RH +Q E ++V EY GS D L+ K L+ ++ + G+AY Sbjct: 73 RHPNTIQYRGCYLREHTAWLVMEYC-LGSASDLLEVHK-KPLQEVEIAAVTHGALQGLAY 130 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL- 438 + N +HRD++A NIL+ E + K+ DFG A ++ W APE L Sbjct: 131 LHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAPAN-----SFVGTPYWMAPEVILA 185 Query: 439 --YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP-CPPECPESLH 495 G++ K DVWS GI EL + + P M L + + E Sbjct: 186 MDEGQYDGKVDVWSLGITCIELAER-KPPLFNMNAMSALYHIAQNESPALQSGHWSEYFR 244 Query: 496 DLMCQCWRKEPEERPTFEYLQAFL 519 + + C +K P++RPT E L Sbjct: 245 NFVDSCLQKIPQDRPTSEVLLKHR 268 >3I6U-A nrPDB Length = 419 Score = 222 bits (566), Expect = 3e-58, Method: Composition-based stats. Identities = 64/277 (23%), Positives = 113/277 (40%), Gaps = 27/277 (9%) Query: 267 RESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQ---------EAQV 316 R+ + LG G GEV + T +VAI+ + + + + E ++ Sbjct: 134 RDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEI 193 Query: 317 MKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 +KKL H ++++ E YIV E M G L D K K L+ Q+ Sbjct: 194 LKKLNHPCIIKIKNFFDAEDYYIVLELMEGGELFD--KVVGNKRLKEATCKLYFYQMLLA 251 Query: 377 MAYVERMNYVHRDLRAANILVG---ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 433 + Y+ +HRDL+ N+L+ E+ + K+ DFG ++++ E + + + A Sbjct: 252 VQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKIL--GETSLMRTLCGTPTYLA 309 Query: 434 PEAAL---YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR-EVLDQVERG---YRMPC 486 PE + + D WS G++L + G P+ + + DQ+ G + Sbjct: 310 PEVLVSVGTAGYNRAVDCWSLGVILFICLS-GYPPFSEHRTQVSLKDQITSGKYNFIPEV 368 Query: 487 PPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 E E DL+ + +P+ R T E A + Sbjct: 369 WAEVSEKALDLVKKLLVVDPKARFTTEE--ALRHPWL 403 >4AF3-A nrPDB Length = 292 Score = 222 bits (565), Expect = 4e-58, Method: Composition-based stats. Identities = 60/279 (21%), Positives = 107/279 (38%), Gaps = 15/279 (5%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPE----AFLQEAQVMK 318 + + LG+G FG V++ + VA+K L + E +E ++ Sbjct: 19 HFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQA 78 Query: 319 KLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 L H +++LY IY++ EY +G L L+ + + ++A + Sbjct: 79 HLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSC--TFDEQRTATIMEELADAL 136 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 437 Y +HRD++ N+L+G K+ADFG + R+ + + PE Sbjct: 137 MYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPS---LRRKTMCGTLDYLPPEMI 193 Query: 438 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDL 497 K D+W G+L EL G P+ + E ++ + + P P DL Sbjct: 194 EGRMHNEKVDLWCIGVLCYELLV-GNPPFESASHNETYRRIVK-VDLKFPASVPTGAQDL 251 Query: 498 MCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL 536 + + R P ER + A + + + P L Sbjct: 252 ISKLLRHNPSERLPLAQVSA--HPWVRANSRRVLPPSAL 288 >4U41-A nrPDB Length = 332 Score = 221 bits (564), Expect = 5e-58, Method: Composition-based stats. Identities = 66/278 (23%), Positives = 115/278 (41%), Gaps = 20/278 (7%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTRVA-IKTLKPGTMSPEAFLQEAQVMKKLRHE- 323 P L +G G +G+V+ G T ++A IK + E E ++KK H Sbjct: 22 PAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHR 81 Query: 324 KLVQLYAVV-------SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 + Y ++ +++V E+ GS+ D +K G L+ + ++ +I G Sbjct: 82 NIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRG 141 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 +A++ + +HRD++ N+L+ EN K+ DFG++ + D R W APE Sbjct: 142 LAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQL-DRTVGRRNTFIGTPYWMAPEV 200 Query: 437 ALYGR-----FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPC-PPEC 490 + +SD+WS GI E+ +G P M L + R + Sbjct: 201 IACDENPDATYDYRSDLWSCGITAIEMA-EGAPPLCDMHPMRALFLIPRNPPPRLKSKKW 259 Query: 491 PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEP 528 + + C K +RP+ E L L+ F +P Sbjct: 260 SKKFFSFIEGCLVKNYMQRPSTEQL---LKHPFIRDQP 294 >4F0G-A nrPDB Length = 287 Score = 221 bits (563), Expect = 6e-58, Method: Composition-based stats. Identities = 79/285 (27%), Positives = 130/285 (45%), Gaps = 28/285 (9%) Query: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTW-NGTTRVAIKTLKPGTMSPE--------A 309 + + E ++G+G FG V G + VAIK+L G E Sbjct: 10 KSRLPTLADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQE 69 Query: 310 FLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDM 369 F +E +M L H +V+LY ++ P +V E++ G L L + ++ + + Sbjct: 70 FQREVFIMSNLNHPNIVKLYGLMHNPPR-MVMEFVPCGDLYHRL-LDKAHPIKWSVKLRL 127 Query: 370 AAQIASGMAYVERMN--YVHRDLRAANILV---GENLVC--KVADFGLARLIEDNEYTAR 422 IA G+ Y++ N VHRDLR+ NI + EN KVADFGL++ + Sbjct: 128 MLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQ----SVHSV 183 Query: 423 QGAKFPIKWTAPEAA--LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREV--LDQV 478 G +W APE +T K+D +SF ++L + T G P+ ++ ++ + Sbjct: 184 SGLLGNFQWMAPETIGAEEESYTEKADTYSFAMILYTILT-GEGPFDEYSYGKIKFINMI 242 Query: 479 -ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 E G R P +CP L +++ CW +P++RP F Y+ L + Sbjct: 243 REEGLRPTIPEDCPPRLRNVIELCWSGDPKKRPHFSYIVKELSEL 287 >3ORZ-A nrPDB Length = 316 Score = 220 bits (561), Expect = 1e-57, Method: Composition-based stats. Identities = 63/280 (22%), Positives = 110/280 (39%), Gaps = 19/280 (6%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEA----FLQEAQVMKKLRH 322 E + LG+G F V + T+R AIK L+ + E +E VM +L H Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDH 96 Query: 323 EKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 V+LY +E +Y Y G LL +++ A+I S + Y+ Sbjct: 97 PFFVKLYFCFQDDEKLYFGLSYAKNGELLKYIRKIGS--FDETCTRFYTAEIVSALEYLH 154 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGA-KFPIKWTAPEAALYG 440 +HRDL+ NIL+ E++ ++ DFG A+++ AR + ++ +PE Sbjct: 155 GKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEK 214 Query: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQ 500 SD+W+ G ++ +L G P+ + ++ + P + DL+ + Sbjct: 215 SACKSSDLWALGCIIYQLVA-GLPPFRAGNEYLIFQKIIK-LEYDFPEKFFPKARDLVEK 272 Query: 501 CWRKEPEERPTFEYL--------QAFLEDYFTSTEPQYQP 532 + +R E + F E Q P Sbjct: 273 LLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENLHQQTP 312 >3GC9-A nrPDB Length = 370 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 76/338 (22%), Positives = 133/338 (39%), Gaps = 59/338 (17%) Query: 242 HRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTW-NGTTRVAIKTL 300 H L P + Q L K WE+P+ L+ +G G +G V +VA+K L Sbjct: 3 HMLEMSGPRAGFYRQELNKTVWEVPQ-RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKL 61 Query: 301 KP---GTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE-------EPIYIVTEYMSKGSLL 350 + +E +++K L+HE ++ L V + +Y+VT M L Sbjct: 62 SRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLM-GADLN 120 Query: 351 DFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGL 410 + +K + L + + Q+ G+ Y+ +HRDL+ +N+ V E+ ++ DFGL Sbjct: 121 NIVKSQA---LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGL 177 Query: 411 ARLIEDNEYTARQGAKFPIKWTAPEAALY-GRFTIKSDVWSFGILLTELTTKGRVPYPGM 469 AR D E T ++ + APE L + D+WS G ++ EL +G+ +PG Sbjct: 178 ARQ-ADEEMTGYVATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELL-QGKALFPGS 232 Query: 470 VNREVLDQVERGYRMPCP-----------------------PECPESLH-------DLMC 499 + L ++ P P + DL+ Sbjct: 233 DYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLG 292 Query: 500 QCWRKEPEERPTFEYLQAFLEDYFTS-----TEPQYQP 532 + + ++R + A YF+ EP+ +P Sbjct: 293 RMLVLDSDQRVSAAE--ALAHAYFSQYHDPEDEPEAEP 328 >3NYO-A nrPDB Length = 576 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 69/296 (23%), Positives = 119/296 (40%), Gaps = 15/296 (5%) Query: 223 FNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFG 282 F L +L Y A Q + + + + R LG+G FG Sbjct: 142 FQELTRLTHEYLSVA---PFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFG 198 Query: 283 EVWMGTWNGTTR-VAIKTLKPGTMSPEA----FLQEAQVMKKLRHEKLVQL-YAVVSEEP 336 EV T + A K L+ + L E Q+++K+ +V L YA +++ Sbjct: 199 EVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDA 258 Query: 337 IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANIL 396 + +V M+ G L + + V AA+I G+ + R V+RDL+ NIL Sbjct: 259 LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENIL 318 Query: 397 VGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLT 456 + ++ +++D GLA + + + +G + + APE R+T D W+ G LL Sbjct: 319 LDDHGHIRISDLGLAVHVPEGQ--TIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLY 376 Query: 457 ELTTKGRVPYPGMV---NREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEER 509 E+ G+ P+ RE ++++ + L Q K+P ER Sbjct: 377 EMIA-GQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAER 431 >5FET-A nrPDB Length = 847 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 61/281 (21%), Positives = 109/281 (38%), Gaps = 17/281 (6%) Query: 238 DGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT-RVA 296 D P + + ++ L E +G+G FG V + T R A Sbjct: 503 DKSVFLQIIQGPMLTHLEERIKMQDTKVEMHELETERIIGRGTFGTVKLVHHKPTQIRYA 562 Query: 297 IKTLKPGTM----SPEAFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLD 351 +K + ++ E ++ + H +++L + Y +TE ++ G L D Sbjct: 563 LKCVSKRSIISLNQQNNIKLEREITAENDHPFIIRLVRTFKDSNCFYFLTELVTGGELYD 622 Query: 352 FLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLA 411 ++ L PQ I + Y+ N V+RDL+ NIL+ + K+ DFG A Sbjct: 623 AIRKLG--LLSKPQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCA 680 Query: 412 RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM-- 469 + I+ YT + APE L + D+W+ G+ L E G +P+ Sbjct: 681 KKIQGRAYTL----VGTPHYMAPEVILGKGYGCTVDIWALGVCLYEFIC-GPLPFGNDQE 735 Query: 470 VNREVLDQVERGYRMPCPPECPE-SLHDLMCQCWRKEPEER 509 E+ + G ++ P + +LM + + P+ R Sbjct: 736 DQLEIFRDILTG-QLTFPDYVSDQDSINLMKRLLCRLPQGR 775 >4PDS-A nrPDB Length = 347 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 60/265 (22%), Positives = 117/265 (44%), Gaps = 27/265 (10%) Query: 272 LEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTM--SPEAFLQEAQVMKKLRHEKLVQL 328 ++ +GQG F V T + ++K + + + + +E +V++KL H ++V+L Sbjct: 35 IDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVTRELEVLQKLNHPRIVRL 94 Query: 329 YAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 + E Y+V E++S G L+DF+ + +++ QI + + Y+ M H Sbjct: 95 KGFYEDTESYYMVMEFVSGGDLMDFVAAHG--AVGEDAGREISRQILTAIKYIHSMGISH 152 Query: 388 RDLRAANILVGENL--VCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG----- 440 RDL+ NIL+ ++ + K+ FGLA++ + + + + + APE Sbjct: 153 RDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSF--MKTFCGTLAYVAPEVIRGKDTSVS 210 Query: 441 --------RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE--- 489 ++ D+WS G L+ + T G +P+ G ++ Q+ RG P + Sbjct: 211 PDEYEERNEYSSLVDMWSMGCLVYVILT-GHLPFSGSTQDQLYKQIGRGSYHEGPLKDFR 269 Query: 490 CPESLHDLMCQCWRKEPEERPTFEY 514 E D + + +P R T Sbjct: 270 ISEEARDFIDSLLQVDPNNRSTAAK 294 >6J5U-C nrPDB Length = 426 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 83/321 (25%), Positives = 134/321 (41%), Gaps = 33/321 (10%) Query: 240 LCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR----- 294 L T S P + + + ++ R + LG+G FG V+ G + T+ Sbjct: 56 LPTLRTEGEILSSPNLKAFTFNELKNATKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRP 115 Query: 295 -----VAIKTLKPGTMS-PEAFLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKG 347 VA+K LKP + +L E + +L H LV L +E E +V E+M KG Sbjct: 116 GSGIVVAVKQLKPEGFQGHKEWLTEVNYLGQLSHPNLVLLVGYCAEGENRLLVYEFMPKG 175 Query: 348 SLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN--YVHRDLRAANILVGENLVCKV 405 SL + L + L + +A A G+ ++ ++RD +AANIL+ + K+ Sbjct: 176 SLENHLFRRGAQPLTWAIRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKL 235 Query: 406 ADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTK--- 461 +DFGLA+ + T + APE GR T KSDV+SFG++L EL + Sbjct: 236 SDFGLAKAGPTGDNTHVSTKVIGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELISGRRA 295 Query: 462 --------------GRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPE 507 PY G R++ ++ P + + +L QC + + Sbjct: 296 MDNSNGGNEYSLVDWATPYLG-DKRKLFRIMDTKLGGQYPQKGAFTAANLALQCLNPDAK 354 Query: 508 ERPTFEYLQAFLEDYFTSTEP 528 RP + LE + +P Sbjct: 355 LRPKMSEVLVTLEQLESVAKP 375 >4AW2-A nrPDB Length = 437 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 60/256 (23%), Positives = 104/256 (40%), Gaps = 17/256 (6%) Query: 262 AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEA----FLQEAQV 316 + RE + +G+G FGEV + +V A+K L M A F +E V Sbjct: 68 QMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDV 127 Query: 317 MKKLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIAS 375 + + + L YA + +Y+V +Y G LL L + L A++ Sbjct: 128 LVNGDSKWITTLHYAFQDDNNLYLVMDYYVGGDLLTLLSKFEDR-LPEEMARFYLAEMVI 186 Query: 376 GMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPE 435 + V +++YVHRD++ NIL+ N ++ADFG + ++ A + +PE Sbjct: 187 AIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPE 246 Query: 436 AAL-----YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP-- 488 GR+ + D WS G+ + E+ G P+ E ++ P Sbjct: 247 ILQAMEGGKGRYGPECDWWSLGVCMYEML-YGETPFYAESLVETYGKIMNHKERFQFPTQ 305 Query: 489 --ECPESLHDLMCQCW 502 + E+ DL+ + Sbjct: 306 VTDVSENAKDLIRRLI 321 >2X4F-A nrPDB Length = 373 Score = 219 bits (558), Expect = 3e-57, Method: Composition-based stats. Identities = 66/259 (25%), Positives = 107/259 (41%), Gaps = 14/259 (5%) Query: 274 VKLGQGCFGEVWMGTWNGTT-RVAIKTLK-PGTMSPEAFLQEAQVMKKLRHEKLVQLYAV 331 LG G FG+V T ++A K +K G E E VM +L H L+QLY Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKNEISVMNQLDHANLIQLYDA 154 Query: 332 VS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDL 390 + I +V EY+ G L D + E+ L ++ QI G+ ++ +M +H DL Sbjct: 155 FESKNDIVLVMEYVDGGELFDRIIDESYNLTELDTIL-FMKQICEGIRHMHQMYILHLDL 213 Query: 391 RAANILVGENL--VCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV 448 + NIL K+ DFGLAR + E + ++ APE Y + +D+ Sbjct: 214 KPENILCVNRDAKQIKIIDFGLARRYKPRE--KLKVNFGTPEFLAPEVVNYDFVSFPTDM 271 Query: 449 WSFGILLTELTTKGRVPYPGMVNREVLDQVER---GYRMPCPPECPESLHDLMCQCWRKE 505 WS G++ + G P+ G + E L+ + + E + + + KE Sbjct: 272 WSVGVIAY-MLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFISKLLIKE 330 Query: 506 PEERPTFEYLQAFLEDYFT 524 R + A + + Sbjct: 331 KSWRISASE--ALKHPWLS 347 >6BDL-A nrPDB Length = 347 Score = 219 bits (557), Expect = 3e-57, Method: Composition-based stats. Identities = 63/254 (24%), Positives = 103/254 (40%), Gaps = 13/254 (5%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWN--GTTRVAIKTLKP----GTMSPEAFLQEAQVM 317 + + LG G FG V + + A+K LK T E E Q+M Sbjct: 30 NLKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIM 89 Query: 318 KKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 + + +V+LY + +Y++ E G L L+ A + Sbjct: 90 QGAHSDFIVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGS--FEDSTTRFYTACVVEA 147 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 AY+ ++RDL+ N+++ K+ DFG A+ I + T ++ APE Sbjct: 148 FAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTW--TFCGTPEYVAPEI 205 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM-PCPPECPESLH 495 L I +D WS GIL+ EL T G P+ G + + + RG M P + ++ Sbjct: 206 ILNKGHDISADYWSLGILMYELLT-GSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAA 264 Query: 496 DLMCQCWRKEPEER 509 +L+ + R P ER Sbjct: 265 NLIKKLCRDNPSER 278 >5TOS-A nrPDB Length = 395 Score = 219 bits (557), Expect = 3e-57, Method: Composition-based stats. Identities = 81/306 (26%), Positives = 131/306 (42%), Gaps = 35/306 (11%) Query: 251 SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWN---------GTTRV-AIKTL 300 S + + ++ + R + +G+G FG V+ G + GT V A+K L Sbjct: 48 SSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL 107 Query: 301 K-PGTMSPEAFLQEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGE-- 356 G +L E + +L H LV+L +E +V E+M KGSL + L Sbjct: 108 NQEGFQGHREWLTEINYLGQLSHPNLVKLIGYCLEDEHRLLVYEFMQKGSLENHLFRRGA 167 Query: 357 TGKYLRLPQLVDMAAQIASGMAYVER--MNYVHRDLRAANILVGENLVCKVADFGLARLI 414 K L V++A A G+A++ + ++RD++A+NIL+ + K++DFGLAR Sbjct: 168 YFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDG 227 Query: 415 EDNEYT-ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRV--------- 464 + + + APE G +SDV+SFG+LL E+ + R Sbjct: 228 PMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKE 287 Query: 465 --------PYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQ 516 PY R+VL V+ PE + + QC EP+ RPT + + Sbjct: 288 ENLVDWARPYL-TSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQVV 346 Query: 517 AFLEDY 522 L+ Sbjct: 347 RALQQL 352 >2I0E-A nrPDB Length = 353 Score = 219 bits (557), Expect = 3e-57, Method: Composition-based stats. Identities = 61/253 (24%), Positives = 112/253 (44%), Gaps = 12/253 (4%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPG----TMSPEAFLQEAQVMK 318 + + LG+G FG+V + GT A+K LK E + E +V+ Sbjct: 16 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 75 Query: 319 K-LRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 + L QL++ + + +Y V EY++ G L+ ++ + P V AA+IA G Sbjct: 76 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIG 133 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 + +++ ++RDL+ N+++ K+ADFG+ + + T + P + APE Sbjct: 134 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEI 192 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 Y + D W+FG+LL E+ G+ P+ G E+ + + + P + Sbjct: 193 IAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME-HNVAYPKSMSKEAVA 250 Query: 497 LMCQCWRKEPEER 509 + K P +R Sbjct: 251 ICKGLMTKHPGKR 263 >5WNL-A nrPDB Length = 342 Score = 219 bits (557), Expect = 3e-57, Method: Composition-based stats. Identities = 79/284 (27%), Positives = 135/284 (47%), Gaps = 27/284 (9%) Query: 274 VKLGQGCFGEVWMGTW-NGTTRVAIKT---LKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329 K+G G FG+V+ + T +AIK L L+EA+ M+ + ++ +Y Sbjct: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVY 85 Query: 330 AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN--YVH 387 + +EP+ +V EYM GSL L + L + + A GM ++ M+ +H Sbjct: 86 GIC-QEPVGLVMEYMETGSLEKLL---ASEPLPWDLRFRIVHETAVGMNFLHCMSPPLLH 141 Query: 388 RDLRAANILVGENLVCKVADFGLARL--IEDNEYTARQGAKFPIKWTAPEAALYGR--FT 443 +L+ ANIL+ + K++DFGLA+ + + + G I + PE F Sbjct: 142 LNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRLFD 201 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVN-REVLDQVERGYRMPCPPECPE------SLHD 496 K DV+SF I++ + T+ + P+ N ++ +V +G+R PP C SL Sbjct: 202 TKHDVYSFAIVIWGVLTQKK-PFADEKNILHIMMKVVKGHRPELPPICRPRPRACASLIG 260 Query: 497 LMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ-----YQPGEN 535 LM +CW +P+ RPTF+ + + ED + + ++PGE Sbjct: 261 LMQRCWHADPQVRPTFQEITSETEDLCEKPDEEVKDLAHEPGEK 304 >6E9W-A nrPDB Length = 443 Score = 219 bits (557), Expect = 3e-57, Method: Composition-based stats. Identities = 60/284 (21%), Positives = 114/284 (40%), Gaps = 23/284 (8%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEA----FLQEAQVMK 318 + E + +G+G FGEV + T +V A+K L M + F +E +M Sbjct: 98 RMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 157 Query: 319 KLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 +VQL YA + +Y+V EYM G L++ + + A++ + Sbjct: 158 FANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD---VPEKWARFYTAEVVLAL 214 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 437 + M ++HRD++ N+L+ ++ K+ADFG + A + +PE Sbjct: 215 DAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVL 274 Query: 438 L----YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV---ERGYRMPCPPEC 490 G + + D WS G+ L E+ G P+ ++ + P + Sbjct: 275 KSQGGDGYYGRECDWWSVGVFLYEMLV-GDTPFYADSLVGTYSKIMNHKNSLTFPDDNDI 333 Query: 491 PESLHDLMCQCWRKEPEERP---TFEYLQAFLEDYFTSTEPQYQ 531 + +L+C + E R E ++ L +F + + ++ Sbjct: 334 SKEAKNLICAFLT-DREVRLGRNGVEEIKRHL--FFKNDQWAWE 374 >3PFQ-A nrPDB Length = 674 Score = 219 bits (557), Expect = 4e-57, Method: Composition-based stats. Identities = 61/253 (24%), Positives = 112/253 (44%), Gaps = 12/253 (4%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPG----TMSPEAFLQEAQVMK 318 + + LG+G FG+V + GT A+K LK E + E +V+ Sbjct: 337 RMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLA 396 Query: 319 K-LRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 + L QL++ + + +Y V EY++ G L+ ++ + P V AA+IA G Sbjct: 397 LPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVFYAAEIAIG 454 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 + +++ ++RDL+ N+++ K+ADFG+ + + T + P + APE Sbjct: 455 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP-DYIAPEI 513 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 Y + D W+FG+LL E+ G+ P+ G E+ + + + P + Sbjct: 514 IAYQPYGKSVDWWAFGVLLYEMLA-GQAPFEGEDEDELFQSIME-HNVAYPKSMSKEAVA 571 Query: 497 LMCQCWRKEPEER 509 + K P +R Sbjct: 572 ICKGLMTKHPGKR 584 >4MYG-A nrPDB Length = 372 Score = 218 bits (555), Expect = 5e-57, Method: Composition-based stats. Identities = 74/328 (22%), Positives = 124/328 (37%), Gaps = 58/328 (17%) Query: 249 PTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLKP---GT 304 Q + K AWE+P+ + +G G +G V +VAIK L Sbjct: 25 RKKGFYKQDVNKTAWELPKTYVSP-THVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSE 83 Query: 305 MSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-------PIYIVTEYMSKGSLLDFLKGET 357 + + +E ++K ++HE ++ L V + Y+V +M L+ Sbjct: 84 IFAKRAYRELLLLKHMQHENVIGLLDVFTPASSLRNFYDFYLVMPFM-----QTDLQKIM 138 Query: 358 GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDN 417 G ++ + Q+ G+ Y+ VHRDL+ N+ V E+ K+ DFGLAR D Sbjct: 139 GMEFSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVNEDCELKILDFGLARH-ADA 197 Query: 418 EYTARQGAKFPIKWTAPEAALY-GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLD 476 E T ++ + APE L + D+WS G ++ E+ T G+ + G + L Sbjct: 198 EMTGYVVTRW---YRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLT 253 Query: 477 QVERGYRMP------------------------------CPPECPESLHDLMCQCWRKEP 506 Q+ + +P P DL+ + + Sbjct: 254 QILKVTGVPGTEFVQKLNDKAAKSYIQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDV 313 Query: 507 EERPTFEYLQAFLEDYFTSTEPQYQPGE 534 ++R T QA +F EP P E Sbjct: 314 DKRLTAA--QALTHPFF---EPFRDPEE 336 >4BGQ-A nrPDB Length = 304 Score = 218 bits (555), Expect = 5e-57, Method: Composition-based stats. Identities = 68/293 (23%), Positives = 120/293 (40%), Gaps = 50/293 (17%) Query: 267 RESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMS---PEAFLQEAQVMKKLRH 322 + +G+G +G V T VAIK K + E L+E ++++ L+ Sbjct: 11 MNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQ 70 Query: 323 EKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 E +V+L +Y+V EY+ K ++L+ L+ E + ++ Q+ + + Sbjct: 71 ENIVELKEAFRRRGKLYLVFEYVEK-NMLELLE-EMPNGVPPEKVKSYIYQLIKAIHWCH 128 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 + + VHRD++ N+L+ N V K+ DFG AR + + + +PE L Sbjct: 129 KNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPELLLGAP 188 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER--------------------G 481 + D+WS G +L EL + G+ +PG + L +++ G Sbjct: 189 YGKSVDMWSVGCILGEL-SDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHG 247 Query: 482 YRMPCPPECPESLH------------DLMCQCWRKEPEER---------PTFE 513 R P P+SL DLM + +P +R PTF+ Sbjct: 248 LRFPAV-NHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ 299 >2BRG-A nrPDB Length = 297 Score = 218 bits (555), Expect = 6e-57, Method: Composition-based stats. Identities = 71/256 (27%), Positives = 113/256 (44%), Gaps = 11/256 (4%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKT--LKPGTMSPEAFLQEAQVMKKLRHEK 324 E L LG+G +GEV + T VA+K +K PE +E + K L HE Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINKMLNHEN 66 Query: 325 LVQLYAVVSEEPI-YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 +V+ Y E I Y+ EY S G L D ++ + G + P Q+ +G+ Y+ + Sbjct: 67 VVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIG--MPEPDAQRFFHQLMAGVVYLHGI 124 Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLI-EDNEYTARQGAKFPIKWTAPEAALYGRF 442 HRD++ N+L+ E K++DFGLA + +N + + APE F Sbjct: 125 GITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLKRREF 184 Query: 443 T-IKSDVWSFGILLTELTTKGRVPY--PGMVNREVLDQVERGYRMPCPPECPESLHDLMC 499 DVWS GI+LT + G +P+ P +E D E+ + + + L+ Sbjct: 185 HAEPVDVWSCGIVLTAMLA-GELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLH 243 Query: 500 QCWRKEPEERPTFEYL 515 + + P R T + Sbjct: 244 KILVENPSARITIPDI 259 >3OHT-A nrPDB Length = 389 Score = 218 bits (555), Expect = 6e-57, Method: Composition-based stats. Identities = 78/348 (22%), Positives = 135/348 (38%), Gaps = 60/348 (17%) Query: 232 YYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTW-N 290 Y + ++ + Q L K WE+P L +G G +G V Sbjct: 17 YKKAGSAAAPFTMSHKERPT-FYRQELNKTIWEVPERYQTL-SPVGSGAYGSVCSSYDVK 74 Query: 291 GTTRVAIKTLKP---GTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE-------EPIYIV 340 ++A+K L + + +E +++K ++HE ++ L V + +Y+V Sbjct: 75 SGLKIAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPATSLEEFNDVYLV 134 Query: 341 TEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGEN 400 T M L + +K + L + + QI G+ Y+ + +HRDL+ +N+ V E+ Sbjct: 135 THLM-GADLNNIVKCQK---LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNED 190 Query: 401 LVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY-GRFTIKSDVWSFGILLTELT 459 K+ DFGLAR D+E T ++ + APE L + + D+WS G ++ EL Sbjct: 191 CELKILDFGLARH-TDDEMTGYVATRW---YRAPEIMLNWMHYNMTVDIWSVGCIMAELL 246 Query: 460 TKGRVPYPGMVNREVLDQVERGYRMPCPPECP---------------------------- 491 T GR +PG + L Q+ R P Sbjct: 247 T-GRTLFPGTDHINQLQQIMRLTGTPPASVISRMPSHEARNYINSLPQMPKRNFADVFIG 305 Query: 492 --ESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTS-----TEPQYQP 532 DL+ + + ++R T A YF+ EP+ +P Sbjct: 306 ANPLAVDLLEKMLVLDTDKRITASE--ALAHPYFSQYHDPDDEPESEP 351 >5LOH-A nrPDB Length = 341 Score = 217 bits (554), Expect = 7e-57, Method: Composition-based stats. Identities = 58/275 (21%), Positives = 109/275 (39%), Gaps = 20/275 (7%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPE----AFLQEAQVMKKLRHE 323 E + + +G FG+V++G G A+K +K M + E + + Sbjct: 36 EEFSIVKPISRGAFGKVYLGQ-KGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSP 94 Query: 324 KLVQLY-AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +V LY ++ S +Y+V EY+ G + L Y V +++A + Y+ R Sbjct: 95 FIVHLYYSLQSANNVYLVMEYLIGGDVKSLLH--IYGYFDEEMAVKYISEVALALDYLHR 152 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLA-----RLIEDNEYTARQGAKFPIKWTAPEAA 437 +HRDL+ N+L+ K+ DFGL+ R I + + + APE Sbjct: 153 HGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRTFCGTPDYLAPELL 212 Query: 438 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP---PECPESL 494 L D W+ G+ L E T G P+ ++V + + +P P + ++ Sbjct: 213 LGRAHGPAVDWWALGVCLFEFLT-GIPPFNDETPQQVFQNILKR-DIPWPEGEEKLSDNA 270 Query: 495 HDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 + + +R + L+ F+ + + Sbjct: 271 QSAVEILLTIDDTKRAGMKELKR--HPLFSDVDWE 303 >4EWQ-A nrPDB Length = 383 Score = 217 bits (554), Expect = 7e-57, Method: Composition-based stats. Identities = 80/336 (23%), Positives = 132/336 (39%), Gaps = 55/336 (16%) Query: 240 LCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIK 298 L + Q L K WE+P L +G G +G V T RVA+K Sbjct: 18 LYFQSNASQERPTFYRQELNKTIWEVPERYQNL-SPVGSGAYGSVCAAFDTKTGLRVAVK 76 Query: 299 TLKP---GTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE-------EPIYIVTEYMSKGS 348 L + + +E +++K ++HE ++ L V + +Y+VT M Sbjct: 77 KLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLM-GAD 135 Query: 349 LLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADF 408 L + +K + L + + QI G+ Y+ + +HRDL+ +N+ V E+ K+ DF Sbjct: 136 LNNIVKCQK---LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDF 192 Query: 409 GLARLIEDNEYTARQGAKFPIKWTAPEAALY-GRFTIKSDVWSFGILLTELTTKGRVPYP 467 GLAR D+E T ++ + APE L + D+WS G ++ EL T GR +P Sbjct: 193 GLARH-TDDEMTGYVATRW---YRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRTLFP 247 Query: 468 GMVNREVLDQVERGYRMP---CPPECPES---------------------------LHDL 497 G + + L + R P + DL Sbjct: 248 GTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDL 307 Query: 498 MCQCWRKEPEERPTFEYLQAFLEDYFTS-TEPQYQP 532 + + + ++R T QA YF +P +P Sbjct: 308 LEKMLVLDSDKRITAA--QALAHAYFAQYHDPDDEP 341 >4QTB-A nrPDB Length = 380 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 76/332 (22%), Positives = 135/332 (40%), Gaps = 50/332 (15%) Query: 241 CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWN-GTTRVAIKT 299 R V P + + + +++ +L+ +G+G +G V + TRVAIK Sbjct: 15 PRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQY-IGEGAYGMVSSAYDHVRKTRVAIKK 73 Query: 300 LKPGTMSP--EAFLQEAQVMKKLRHEKLVQLYAVVSE------EPIYIVTEYMSKGSLLD 351 + P + L+E Q++ + RHE ++ + ++ +YIV + M L Sbjct: 74 ISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMET-DLYK 132 Query: 352 FLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLA 411 LK + L + QI G+ Y+ N +HRDL+ +N+L+ K+ DFGLA Sbjct: 133 LLKSQQ---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLA 189 Query: 412 RLIE-DNEYTARQGAKFPIKW-TAPEAALYGR-FTIKSDVWSFGILLTELTTKGRVPYPG 468 R+ + ++++T +W APE L + +T D+WS G +L E+ + R +PG Sbjct: 190 RIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN-RPIFPG 248 Query: 469 MVNREVLDQVERGYRMP------------------------------CPPECPESLHDLM 498 + L+ + P P+ DL+ Sbjct: 249 KHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLL 308 Query: 499 CQCWRKEPEERPTFEY--LQAFLEDYFTSTEP 528 + P +R T E +LE Y+ T+ Sbjct: 309 DRMLTFNPNKRITVEEALAHPYLEQYYDPTDE 340 >2W96-B nrPDB Length = 306 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 59/299 (19%), Positives = 112/299 (37%), Gaps = 45/299 (15%) Query: 268 ESLRLEVKLGQGCFGEVWMGTW-NGTTRVAIKTLKP---GTMSPEAFLQEAQVMKKLR-- 321 ++G G +G V+ + VA+K+++ P + ++E ++++L Sbjct: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEGLPISTVREVALLRRLEAF 63 Query: 322 -HEKLVQLYAVVSEE------PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 374 H +V+L V + + +V E++ + L +L L + D+ Q Sbjct: 64 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFL 122 Query: 375 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 434 G+ ++ VHRDL+ NILV K+ADFGLAR+ A + + AP Sbjct: 123 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS--YQMALDPVVVTLWYRAP 180 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESL 494 E L + D+WS G + E+ + + + G + L ++ +P + P + Sbjct: 181 EVLLQSTYATPVDMWSVGCIFAEMF-RRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 239 Query: 495 --------------------------HDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE 527 L+ + P +R + +A Y E Sbjct: 240 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISA--FRALQHSYLHKDE 296 >6E2O-A nrPDB Length = 295 Score = 216 bits (551), Expect = 2e-56, Method: Composition-based stats. Identities = 62/269 (23%), Positives = 115/269 (42%), Gaps = 15/269 (5%) Query: 275 KLGQGCFGEVWMGTWNGTT-RVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVV 332 LG+G +G V+ G R+AIK + + + + +E + K L+H+ +VQ Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSF 88 Query: 333 SEEP-IYIVTEYMSKGSLLDFLKGETGKYLR-LPQLVDMAAQIASGMAYVERMNYVHRDL 390 SE I I E + GSL L+ + G + QI G+ Y+ VHRD+ Sbjct: 89 SENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDI 148 Query: 391 RAANILVGE-NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR--FTIKSD 447 + N+L+ + V K++DFG ++ + +++ APE G + +D Sbjct: 149 KGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFT-GTLQYMAPEIIDKGPRGYGKAAD 207 Query: 448 VWSFGILLTELTTKGRVPYP--GMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKE 505 +WS G + E+ T G+ P+ G + P + +C+ + Sbjct: 208 IWSLGCTIIEMAT-GKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPD 266 Query: 506 PEERPTFEYLQAFLEDYF--TSTEPQYQP 532 P++R L ++++ +S + + QP Sbjct: 267 PDKRACANDL--LVDEFLKVSSKKKKTQP 293 >5NGU-A nrPDB Length = 381 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 74/301 (24%), Positives = 127/301 (42%), Gaps = 52/301 (17%) Query: 276 LGQGCFGEVWMGTWN-GTTRVAIKTLKPGTMSP--EAFLQEAQVMKKLRHEKLVQLYAVV 332 +G+G +G V N RVAIK + P + L+E +++ + RHE ++ + ++ Sbjct: 50 IGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDII 109 Query: 333 SE------EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 + +YIV + M L LK ++L + QI G+ Y+ N + Sbjct: 110 RAPTIEQMKDVYIVQDLMET-DLYKLLKT---QHLSNDHICYFLYQILRGLKYIHSANVL 165 Query: 387 HRDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKW-TAPEAALYGR-FT 443 HRDL+ +N+L+ K+ DFGLAR+ + D+++T +W APE L + +T Sbjct: 166 HRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYT 225 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE-------------------RGYRM 484 D+WS G +L E+ + R +PG + L+ + R Y + Sbjct: 226 KSIDIWSVGCILAEMLSN-RPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLL 284 Query: 485 PCP-----------PECPESLHDLMCQCWRKEPEERPTFEY--LQAFLEDYFTSTEPQYQ 531 P P DL+ + P +R E +LE Y+ +P + Sbjct: 285 SLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYY---DPSDE 341 Query: 532 P 532 P Sbjct: 342 P 342 >5DYK-A nrPDB Length = 853 Score = 216 bits (549), Expect = 3e-56, Method: Composition-based stats. Identities = 62/305 (20%), Positives = 117/305 (38%), Gaps = 24/305 (7%) Query: 238 DGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT-RVA 296 D P + + ++ + L E +G+G FG V + T R A Sbjct: 509 DKSVFLQIIQGPMLAHLEERIKMQDTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRYA 568 Query: 297 IKTLKPGTM----SPEAFLQEAQVMKKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLD 351 +K + ++ E ++ + H +++L + Y +TE ++ G L D Sbjct: 569 LKCVSKRSIINLNQQNNIKLEREITAENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYD 628 Query: 352 FLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLA 411 ++ L Q I + Y+ N V+RDL+ NIL+ + K+ DFG A Sbjct: 629 AIRKLG--LLSKSQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCA 686 Query: 412 RLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPY--PGM 469 + ++ YT + APE L + D+W+ GI L E G +P+ Sbjct: 687 KKVQGRAYTL----VGTPHYMAPEVILGKGYGCTVDIWALGICLYEFIC-GPLPFGNDEE 741 Query: 470 VNREVLDQVERGYRMPCPPECPE-SLHDLMCQCWRKEPEERP-----TFEYLQAFLEDYF 523 E+ + G ++ P + +LM + + P+ R F+ ++ +F Sbjct: 742 DQLEIFRDILTG-QLTFPDYVTDTDSINLMKRLLCRLPQGRIGCSINGFKDIKD--HPFF 798 Query: 524 TSTEP 528 ++ Sbjct: 799 SNFNW 803 >6DTL-A nrPDB Length = 364 Score = 216 bits (549), Expect = 3e-56, Method: Composition-based stats. Identities = 65/293 (22%), Positives = 110/293 (37%), Gaps = 48/293 (16%) Query: 275 KLGQGCFGEVWMGTWNGTTR-VAIKTLKP---GTMSPEAFLQEAQVMKKLRHEKLVQLYA 330 +G+G +G V + T VAIK + + + L+E ++++ + HE +V + Sbjct: 37 PIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDAKRTLREIKLLRHMDHENIVAIRD 96 Query: 331 VVSE------EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN 384 ++ +YI E M L ++ + L QI G+ Y+ N Sbjct: 97 IIPPPLRNAFNDVYIAYELMDT-DLHQIIRSN--QALSEEHCQYFLYQILRGLKYIHSAN 153 Query: 385 YVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY-GRFT 443 +HRDL+ +N+L+ N K+ DFGLAR+ ++++ + APE L +T Sbjct: 154 VLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYV--VTRWYRAPELLLNSSDYT 211 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPC----------------- 486 DVWS G + EL + + +PG + L + P Sbjct: 212 AAIDVWSVGCIFMELMDR-KPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRYIRQ 270 Query: 487 ------------PPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE 527 P DL+ + +P R T L A Y S Sbjct: 271 LPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITV--LDALAHPYLNSLH 321 >4EQM-A nrPDB Length = 294 Score = 216 bits (549), Expect = 3e-56, Method: Composition-based stats. Identities = 63/276 (22%), Positives = 123/276 (44%), Gaps = 17/276 (6%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWN-GTTRVAIKTL----KPGTMSPEAFLQEAQVMK 318 +I E ++ KLG G V++ +VAIK + + + + F +E Sbjct: 7 KIINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETLKRFEREVHNSS 66 Query: 319 KLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 +L H+ +V + V E+ Y +V EY+ +L ++++ L + ++ QI G+ Sbjct: 67 QLSHQNIVSMIDVDEEDDCYYLVMEYIEGPTLSEYIESHG--PLSVDTAINFTNQILDGI 124 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 437 + M VHRD++ NIL+ N K+ DFG+A+ + + T +++ +PE A Sbjct: 125 KHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGTVQYFSPEQA 184 Query: 438 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVN-----REVLDQVERGYRMPCPPECPE 492 +D++S GI+L E+ G P+ G + + D V + P+ Sbjct: 185 KGEATDECTDIYSIGIVLYEMLV-GEPPFNGETAVSIAIKHIQDSVPN-VTTDVRKDIPQ 242 Query: 493 SLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEP 528 SL +++ + K+ R ++ +Q +D + Sbjct: 243 SLSNVILRATEKDKANR--YKTIQEMKDDLSSVLHE 276 >1KOB-A nrPDB Length = 387 Score = 216 bits (549), Expect = 3e-56, Method: Composition-based stats. Identities = 62/266 (23%), Positives = 111/266 (41%), Gaps = 13/266 (4%) Query: 255 TQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAI-KTLK-PGTMSPEAFLQ 312 Q + + + + +LG G FG V T RV + K + P + Sbjct: 39 PQPVEVKQGSV-YDYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVKN 97 Query: 313 EAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA 371 E +M +L H KL+ L+ ++ + ++ E++S G L D + E K + ++++ Sbjct: 98 EISIMNQLHHPKLINLHDAFEDKYEMVLILEFLSGGELFDRIAAEDYK-MSEAEVINYMR 156 Query: 372 QIASGMAYVERMNYVHRDLRAANILVGEN--LVCKVADFGLARLIEDNEYTARQGAKFPI 429 Q G+ ++ + VH D++ NI+ K+ DFGLA + +E A Sbjct: 157 QACEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTA--TA 214 Query: 430 KWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER---GYRMPC 486 ++ APE +D+W+ G+L L + G P+ G + E L V+R + Sbjct: 215 EFAAPEIVDREPVGFYTDMWAIGVLGYVLLS-GLSPFAGEDDLETLQNVKRCDWEFDEDA 273 Query: 487 PPECPESLHDLMCQCWRKEPEERPTF 512 D + +KEP +R T Sbjct: 274 FSSVSPEAKDFIKNLLQKEPRKRLTV 299 >1PHK-A nrPDB Length = 298 Score = 216 bits (549), Expect = 3e-56, Method: Composition-based stats. Identities = 59/278 (21%), Positives = 113/278 (40%), Gaps = 29/278 (10%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLK----------PGTMSPEAFLQEAQV 316 E+ + LG+G V T A+K + EA L+E + Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 317 MKKLR-HEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 374 ++K+ H ++QL + +V + M KG L D+L + L + + + Sbjct: 77 LRKVSGHPNIIQLKDTYETNTFFFLVFDLMKKGELFDYLTEKV--TLSEKETRKIMRALL 134 Query: 375 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 434 + + ++N VHRDL+ NIL+ +++ K+ DFG + ++ E + AP Sbjct: 135 EVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVC--GTPSYLAP 192 Query: 435 EAALYG------RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMP 485 E + + D+WS G+++ L G P+ +L + G + P Sbjct: 193 EIIECSMNDNHPGYGKEVDMWSTGVIMYTLLA-GSPPFWHRKQMLMLRMIMSGNYQFGSP 251 Query: 486 CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 + +++ DL+ + +P++R T E A +F Sbjct: 252 EWDDYSDTVKDLVSRFLVVQPQKRYTAEE--ALAHPFF 287 >3ZDU-A nrPDB Length = 325 Score = 215 bits (548), Expect = 3e-56, Method: Composition-based stats. Identities = 66/294 (22%), Positives = 118/294 (40%), Gaps = 45/294 (15%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTL--KPGTMSPEAFLQEAQVMKKLRHEKLV 326 K+G+G +G V T + VAIK +P + ++E + +K+ HE LV Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQFHHENLV 64 Query: 327 QLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 L V ++ I++V E++ L + L +L QI + Y+ N Sbjct: 65 NLIEVFRQKKKIHLVFEFIDHTVLDEL--QHYCHGLESKRLRKYLFQILRAIDYLHSNNI 122 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEAALYG-RF 442 +HRD++ NILV ++ + K+ DFG AR + + Y ++ + APE L + Sbjct: 123 IHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRW---YRAPELVLKDTSY 179 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP--------------- 487 D+W+ G ++ E+ T G P + ++L ++ P Sbjct: 180 GKPVDIWALGCMIIEMAT-GNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGV 238 Query: 488 ---------------PECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 P+ L D++ C + +P +R + L +YFT Sbjct: 239 VLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLH--HEYFTRD 290 >5AWM-A nrPDB Length = 394 Score = 215 bits (548), Expect = 4e-56, Method: Composition-based stats. Identities = 66/349 (18%), Positives = 130/349 (37%), Gaps = 67/349 (19%) Query: 245 TTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKP- 302 T + T + + I + L +G G G V T + VAIK L Sbjct: 22 TMTTAQHQHYTVEVGDTNFTIHSRYINL-RPIGSGAQGIVCAAYDTITQQNVAIKKLSRP 80 Query: 303 --GTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE-------PIYIVTEYMSKGSLLDFL 353 + +E ++MK + H+ ++ L + + +Y+V E M +L + Sbjct: 81 FQNVTHAKRAYREFKLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDA-NLCQVI 139 Query: 354 KGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARL 413 + + L ++ + Q+ G+ ++ +HRDL+ +NI+V + K+ DFGLAR Sbjct: 140 QMD----LDHDRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLART 195 Query: 414 IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNRE 473 + APE L +T D+WS G ++ E+ +G V +PG + + Sbjct: 196 AGTTFMMTPYV--VTRYYRAPEVILGMGYTENVDIWSVGCIMGEMI-RGGVLFPGTDHID 252 Query: 474 VLDQVERGYRMPCPPE--------------------------CPESL------------- 494 +++ P P P+ L Sbjct: 253 QWNKIIEQLGTPSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKA 312 Query: 495 ---HDLMCQCWRKEPEERPTFEYL--QAFLEDYFTSTE---PQYQPGEN 535 +L+ + +PE+R + + ++ ++ + E P +P ++ Sbjct: 313 SDARNLLSKMLVIDPEQRISVDEALKHEYINVWYDAEEVDAPAPEPYDH 361 >6ED6-A nrPDB Length = 415 Score = 215 bits (548), Expect = 4e-56, Method: Composition-based stats. Identities = 59/283 (20%), Positives = 113/283 (39%), Gaps = 23/283 (8%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEA----FLQEAQVMK 318 ++ E + +G+G FGEV + + +V A+K L M + F +E +M Sbjct: 84 QMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMA 143 Query: 319 KLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 +VQL YA + +Y+V EYM G L++ + + A++ + Sbjct: 144 FANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYD---VPEKWAKFYTAEVVLAL 200 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 437 + M +HRD++ N+L+ ++ K+ADFG +++ A + +PE Sbjct: 201 DAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVL 260 Query: 438 LYGR----FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP---EC 490 + + D WS G+ L E+ G P+ ++ C P E Sbjct: 261 KSQGGDGFYGRECDWWSVGVFLYEMLV-GDTPFYADSLVGTYSKIMDHKNSLCFPEDAEI 319 Query: 491 PESLHDLMCQCWRKEPEERP---TFEYLQAFLEDYFTSTEPQY 530 + +L+C + E R E ++ +F + + + Sbjct: 320 SKHAKNLICAFLT-DREVRLGRNGVEEIRQ--HPFFKNDQWHW 359 >3TAC-A nrPDB Length = 361 Score = 215 bits (547), Expect = 5e-56, Method: Composition-based stats. Identities = 60/258 (23%), Positives = 102/258 (39%), Gaps = 17/258 (6%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGT------MSPEAFLQEAQVMKKLRH 322 L +G+G F V T + A+K + +S E +EA + L+H Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKH 87 Query: 323 EKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFL--KGETGKYLRLPQLVDMAAQIASGMAY 379 +V+L S + +Y+V E+M L + + + G QI + Y Sbjct: 88 PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRY 147 Query: 380 VERMNYVHRDLRAANILVGENLV---CKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 N +HRD++ +L+ K+ FG+A + ++ A G + APE Sbjct: 148 CHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVA-GGRVGTPHFMAPEV 206 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM--PCPPECPESL 494 + DVW G++L L + G +P+ G R ++ Y+M ES Sbjct: 207 VKREPYGKPVDVWGCGVILFILLS-GCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESA 265 Query: 495 HDLMCQCWRKEPEERPTF 512 DL+ + +P ER T Sbjct: 266 KDLVRRMLMLDPAERITV 283 >5UIU-A nrPDB Length = 323 Score = 214 bits (546), Expect = 5e-56, Method: Composition-based stats. Identities = 83/276 (30%), Positives = 131/276 (47%), Gaps = 27/276 (9%) Query: 273 EVKLGQGCFGEVWMGTWNGTTRVAIKTL-----KPGTMSPEAFLQEAQVMKKLRHEKLVQ 327 K+G+G FG V+ G N TT VA+K L + F QE +VM K +HE LV+ Sbjct: 52 GNKMGEGGFGVVYKGYVNNTT-VAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVE 110 Query: 328 LYAVVSE-EPIYIVTEYMSKGSLLDFLKGETG-KYLRLPQLVDMAAQIASGMAYVERMNY 385 L S+ + + +V YM GSLLD L G L +A A+G+ ++ ++ Sbjct: 111 LLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHH 170 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGA-KFPIKWTAPEAALYGRFTI 444 +HRD+++ANIL+ E K++DFGLAR E T + APEA G T Sbjct: 171 IHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALR-GEITP 229 Query: 445 KSDVWSFGILLTELTTKGRVPYPGMVNREVL---------------DQVERGYRMPCPPE 489 KSD++SFG++L E+ T G ++L D +++ Sbjct: 230 KSDIYSFGVVLLEIIT-GLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTS 288 Query: 490 CPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTS 525 E+++ + QC ++ +RP + +Q L++ S Sbjct: 289 V-EAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 323 >3A8W-A nrPDB Length = 345 Score = 214 bits (546), Expect = 6e-56, Method: Composition-based stats. Identities = 58/282 (20%), Positives = 116/282 (41%), Gaps = 27/282 (9%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEAFLQEAQVMKKL-----R 321 + L +G+G + +V + T R+ A+K +K ++ + + Q K + Sbjct: 9 QDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASN 68 Query: 322 HEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 H LV L++ +E ++ V EY++ G L+ ++ + + L +A+I+ + Y+ Sbjct: 69 HPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQ--RKLPEEHARFYSAEISLALNYL 126 Query: 381 ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG 440 ++RDL+ N+L+ K+ D+G+ + T P + APE Sbjct: 127 HERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTP-NYIAPEILRGE 185 Query: 441 RFTIKSDVWSFGILLTELTTKGRVPY--------PGMVNREVLDQVERGYRMPCPPECPE 492 + D W+ G+L+ E+ GR P+ P + L QV ++ P Sbjct: 186 DYGFSVDWWALGVLMFEMMA-GRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSLSV 244 Query: 493 SLHDLMCQCWRKEPEERP------TFEYLQAFLEDYFTSTEP 528 ++ K+P+ER F +Q +F + + Sbjct: 245 KAASVLKSFLNKDPKERLGCHPQTGFADIQG--HPFFRNVDW 284 >3HKO-A nrPDB Length = 345 Score = 214 bits (544), Expect = 1e-55, Method: Composition-based stats. Identities = 73/314 (23%), Positives = 118/314 (37%), Gaps = 59/314 (18%) Query: 267 RESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTM------SPEAFLQEAQVMKK 319 ++ L+ +GQG +G V + N T + AIK + + E E ++MKK Sbjct: 25 QKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKK 84 Query: 320 LRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFL------------------------- 353 L H + +LY V +E I +V E G LLD L Sbjct: 85 LHHPNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQICPCPE 144 Query: 354 -------------KGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGEN 400 + R + ++ QI S + Y+ HRD++ N L N Sbjct: 145 CNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFLFSTN 204 Query: 401 --LVCKVADFGLARL---IEDNEYTARQGAKFPIKWTAPEAAL--YGRFTIKSDVWSFGI 453 K+ DFGL++ + + EY + APE + K D WS G+ Sbjct: 205 KSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAWSAGV 264 Query: 454 LLTELTTKGRVPYPGMVNREVLDQVERG---YRMPCPPECPESLHDLMCQCWRKEPEERP 510 LL L G VP+PG+ + + + QV + P DL+ + +ER Sbjct: 265 LL-HLLLMGAVPFPGVNDADTISQVLNKKLCFENPNYNVLSPLARDLLSNLLNRNVDER- 322 Query: 511 TFEYLQAFLEDYFT 524 F+ ++A + + Sbjct: 323 -FDAMRALQHPWIS 335 >2F9G-A nrPDB Length = 353 Score = 214 bits (544), Expect = 1e-55, Method: Composition-based stats. Identities = 77/328 (23%), Positives = 133/328 (40%), Gaps = 58/328 (17%) Query: 258 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKP--GTMSPEAFLQEA 314 + K +L+ LG+G +G V T T VAIK ++P + L+E Sbjct: 1 MPKRIVYNISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDKPLFALRTLREI 60 Query: 315 QVMKKLRHEKLVQLYAVVSEE------PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVD 368 +++K +HE ++ ++ + + +YI+ E M D + + + L + Sbjct: 61 KILKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQ----TDLHRVISTQMLSDDHIQY 116 Query: 369 MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED-----NEYTARQ 423 Q + + N +HRDL+ +N+L+ N KV DFGLAR+I++ +E T +Q Sbjct: 117 FIYQTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQ 176 Query: 424 GAKF----PIKWTAPEAALYG-RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 + APE L +++ DVWS G +L EL + R +PG R L + Sbjct: 177 SGMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLR-RPIFPGRDYRHQLLLI 235 Query: 479 ----------------------ERGYRMPCPPECP---------ESLHDLMCQCWRKEPE 507 E +P P P DL+ + +P Sbjct: 236 FGIIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPA 295 Query: 508 ERPTFEY--LQAFLEDY-FTSTEPQYQP 532 +R T + +L+ Y + EP+ +P Sbjct: 296 KRITAKEALEHPYLQTYHDPNDEPEGEP 323 >4C0T-A nrPDB Length = 974 Score = 212 bits (539), Expect = 4e-55, Method: Composition-based stats. Identities = 61/289 (21%), Positives = 117/289 (40%), Gaps = 23/289 (7%) Query: 256 QGLAKDAWEIPRE--SLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQ 312 + + + I R + +LG+G + V + T T + A+K L + E ++ Sbjct: 252 KTMDGEMKTIRRNVTDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVK 311 Query: 313 ----EAQVMKKLRHE-KLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQL 366 E + +L + ++ LY ++ +Y V +Y S G LL +K L Sbjct: 312 YVNIEKHALNRLSNRLGVISLYFTFQDKDSLYFVLDYASNGELLTLIKR--YNTLNEECT 369 Query: 367 VDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ--- 423 AQI + Y+ +HRDL+ NIL+ + + ++ DFG ARL+E + + Sbjct: 370 RHFGAQILDAIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPV 429 Query: 424 -----GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 ++ +PE DVW+FG ++ ++ G+ P+ ++ Sbjct: 430 DVRAKSFVGTAEYVSPELLENKYCGKPGDVWAFGCIIYQMIA-GKPPFKATNEYLTFQKI 488 Query: 479 ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE 527 + + P + DL+ + +P R T +Q +F S + Sbjct: 489 TK-LQFAFSAGFPTIIRDLIKKILVLQPSRRATIPEIQK--HYFFQSVD 534 >1UA2-A nrPDB Length = 346 Score = 211 bits (538), Expect = 6e-55, Method: Composition-based stats. Identities = 74/306 (24%), Positives = 122/306 (39%), Gaps = 45/306 (14%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP------EAFLQEAQVMKKL 320 + LG+G F V+ T + VAIK +K G S L+E +++++L Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 321 RHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 H ++ L + I +V ++M + L+ + + L + G+ Y Sbjct: 70 SHPNIIGLLDAFGHKSNISLVFDFME--TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY 439 + + +HRDL+ N+L+ EN V K+ADFGLA+ + A + APE Sbjct: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSF-GSPNRAYTHQVVTRWYRAPELLFG 186 Query: 440 GR-FTIKSDVWSFGILLTELTTKGRVPY-PGMVNREVLDQVERGYRMPCPPECP------ 491 R + + D+W+ G +L EL + VP+ PG + + L ++ P + P Sbjct: 187 ARMYGVGVDMWAVGCILAELLLR--VPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP 244 Query: 492 ---------------------ESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 + L DL+ + P R T QA YF S P Sbjct: 245 DYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITAT--QALKMKYF-SNRPGP 301 Query: 531 QPGENL 536 PG L Sbjct: 302 TPGCQL 307 >2Y7J-A nrPDB Length = 365 Score = 211 bits (538), Expect = 6e-55, Method: Composition-based stats. Identities = 57/272 (20%), Positives = 109/272 (40%), Gaps = 28/272 (10%) Query: 275 KLGQGCFGEVWMGTWNGTT-RVAIKTLKPG---------TMSPEAFLQEAQVMKKL-RHE 323 +G+G V T A+K ++ EA +E +++++ H Sbjct: 101 VIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQVAGHP 160 Query: 324 KLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 ++ L +V + M KG L D+L + L + + + ++++ Sbjct: 161 HIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKV--ALSEKETRSIMRSLLEAVSFLHA 218 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG-- 440 N VHRDL+ NIL+ +N+ +++DFG + +E E + APE Sbjct: 219 NNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELC--GTPGYLAPEILKCSMD 276 Query: 441 ----RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPCPPECPES 493 + + D+W+ G++L L G P+ +L + G + P + + Sbjct: 277 ETHPGYGKEVDLWACGVILFTLLA-GSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSST 335 Query: 494 LHDLMCQCWRKEPEERPTFEYLQAFLEDYFTS 525 + DL+ + + +PE R T E QA +F Sbjct: 336 VKDLISRLLQVDPEARLTAE--QALQHPFFER 365 >4FR4-A nrPDB Length = 384 Score = 211 bits (537), Expect = 7e-55, Method: Composition-based stats. Identities = 57/271 (21%), Positives = 114/271 (42%), Gaps = 20/271 (7%) Query: 257 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGT----MSPEAFL 311 + + ++ + + +G+G FG+V + N T + A+K + Sbjct: 4 PVFDENEDVNFDHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRNVF 63 Query: 312 QEAQVMKKLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMA 370 +E Q+M+ L H LV L Y+ EE +++V + + G L L+ + + + Sbjct: 64 KELQIMQGLEHPFLVNLWYSFQDEEDMFMVVDLLLGGDLRYHLQQNV--HFKEETVKLFI 121 Query: 371 AQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIK 430 ++ + Y++ +HRD++ NIL+ E+ + DF +A ++ T Sbjct: 122 CELVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLP--RETQITTMAGTKP 179 Query: 431 WTAPEAALYGR---FTIKSDVWSFGILLTELTTKGRVPYP---GMVNREVLDQVERGYRM 484 + APE + ++ D WS G+ EL +GR PY ++E++ E + Sbjct: 180 YMAPEMFSSRKGAGYSFAVDWWSLGVTAYELL-RGRRPYHIRSSTSSKEIVHTFET-TVV 237 Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYL 515 P + + L+ + P++R F L Sbjct: 238 TYPSAWSQEMVSLLKKLLEPNPDQR--FSQL 266 >5G6V-A nrPDB Length = 324 Score = 211 bits (537), Expect = 8e-55, Method: Composition-based stats. Identities = 70/288 (24%), Positives = 119/288 (41%), Gaps = 40/288 (13%) Query: 273 EVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMS--PEAFLQEAQVMKKLRHEKLVQLY 329 KLG+G + V+ G T VA+K ++ P ++E ++K L+H +V L+ Sbjct: 7 LDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLH 66 Query: 330 AVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 ++ +E+ + +V EY+ K L +L + G + + + Q+ G+AY R +HR Sbjct: 67 DIIHTEKSLTLVFEYLDK-DLKQYL-DDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHR 124 Query: 389 DLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG-RFTIKSD 447 DL+ N+L+ E K+ADFGLAR + + + P+ L ++ + D Sbjct: 125 DLKPQNLLINERGELKLADFGLARA-KSIPTKTYDNEVVTLWYRPPDILLGSTDYSTQID 183 Query: 448 VWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP-----ESLH------- 495 +W G + E+ T GR +PG E L + R P P E Sbjct: 184 MWGVGCIFYEMAT-GRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKY 242 Query: 496 -----------------DLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 DL+ + + E R + E A +F S Sbjct: 243 RAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAED--AMKHPFFLSL 288 >6CTH-A nrPDB Length = 309 Score = 210 bits (536), Expect = 8e-55, Method: Composition-based stats. Identities = 75/291 (25%), Positives = 130/291 (44%), Gaps = 30/291 (10%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKL 325 + E KLG+G FG V+ G + T +A+K + + + + E +++ +LRH+ L Sbjct: 15 SNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYASEVKIISRLRHKNL 74 Query: 326 VQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN 384 V+L E + +V E+M+ GSL + L + +AS + Y+ Sbjct: 75 VKLIGWCHERGELMLVYEFMANGSLDSHIFK-GKSLLTWEVRYRIVKDLASALLYLHEEG 133 Query: 385 ---YVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 441 +HRD++ +NI++ + K+ DFGLARL++ + + + + APE G+ Sbjct: 134 DHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAGTVGYMAPECLSSGK 193 Query: 442 FTIKSDVWSFGILLTELTTKGR--------------VPYPGMV--NREVLDQVERGYRMP 485 + +SDV+SFG++ E+ + R VP+ N +LD +R M Sbjct: 194 ASKESDVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVWESYGNERILDIADRKLGMA 253 Query: 486 CPPECPESLHDLMCQCWRKEPEE--RPTFEYLQAFLEDYFTSTEPQYQPGE 534 P+ E L +M W P RP+ + L F + P PG Sbjct: 254 FDPKQLECL--VMVGLWCAHPSHNLRPSIRQVIQVLN--FEAPLPNL-PGS 299 >6CCF-A nrPDB Length = 290 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 68/301 (22%), Positives = 121/301 (40%), Gaps = 50/301 (16%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAI------------------------- 297 + +L+ ++G+G +G V + R A+ Sbjct: 1 SMQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQA 60 Query: 298 ------KTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE---EPIYIVTEYMSKGS 348 K L P E QE ++KKL H +V+L V+ + + +Y+V + + KG Sbjct: 61 AQGGPAKQLLP----LERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGP 116 Query: 349 LLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADF 408 +++ K Q + G+ Y+ VHRD++ +N+L+G++ K+ADF Sbjct: 117 VMEV---PCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADF 173 Query: 409 GLARLIEDNEYTARQGAKFPIKWTAPEAA--LYGRFTIKS-DVWSFGILLTELTTKGRVP 465 G++ E N+ + APEA F+ K+ DVW+ G+ L G+ P Sbjct: 174 GVSNQFEGND-AQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLY-CFVYGKCP 231 Query: 466 YPGMVNREVLDQVERG-YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFT 524 + + +++ P PE E L DL+ + K PE R ++ L + T Sbjct: 232 FIDDFILALHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIK--LHPWVT 289 Query: 525 S 525 Sbjct: 290 K 290 >4YHJ-A nrPDB Length = 584 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 62/301 (20%), Positives = 119/301 (39%), Gaps = 15/301 (4%) Query: 218 TSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLG 277 S+ F ++ Y + G Q + + + + R LG Sbjct: 138 PSKKAFEECTRVAHNYLR---GEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLG 194 Query: 278 QGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEA----FLQEAQVMKKLRHEKLVQL-YAV 331 +G FGEV T + A K L+ + L E ++++K++ +V L YA Sbjct: 195 KGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILEKVQSRFVVSLAYAY 254 Query: 332 VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLR 391 +++ + +V M+ G L + + V AA++ G+ ++R V+RDL+ Sbjct: 255 ETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLK 314 Query: 392 AANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 451 NIL+ + +++D GLA I + + G + + APE ++T D W Sbjct: 315 PENILLDDRGHIRISDLGLATEIPEGQRVR--GRVGTVGYMAPEVVNNEKYTFSPDWWGL 372 Query: 452 GILLTELTTKGRVPYPGMVNREVLDQVE---RGYRMPCPPECPESLHDLMCQCWRKEPEE 508 G L+ E+ +G P+ + ++V+ + + E + K P + Sbjct: 373 GCLIYEMI-QGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSK 431 Query: 509 R 509 R Sbjct: 432 R 432 >3FME-A nrPDB Length = 290 Score = 209 bits (532), Expect = 3e-54, Method: Composition-based stats. Identities = 67/281 (23%), Positives = 119/281 (42%), Gaps = 20/281 (7%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLK--PGTMSPEAFLQEAQV-MK 318 E+ + L ++LG+G +G V + ++ A+K ++ + + L + + M+ Sbjct: 2 MEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 61 Query: 319 KLRHEKLVQLYAV-VSEEPIYIVTEYMSKGSLLDFLKG--ETGKYLRLPQLVDMAAQIAS 375 + V Y E ++I E M SL F K + G+ + L +A I Sbjct: 62 TVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVK 120 Query: 376 GMAYVERM-NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 434 + ++ + +HRD++ +N+L+ K+ DFG++ + D+ P + AP Sbjct: 121 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCKP--YMAP 178 Query: 435 EAA----LYGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQVERGYRMPCP-P 488 E +++KSD+WS GI + EL R PY + L QV P Sbjct: 179 ERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLKQVVEEPSPQLPAD 237 Query: 489 ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 + D QC +K +ERPT+ L +FT E + Sbjct: 238 KFSAEFVDFTSQCLKKNSKERPTYPELMQ--HPFFTLHESK 276 >3UTO-A nrPDB Length = 573 Score = 209 bits (532), Expect = 3e-54, Method: Composition-based stats. Identities = 68/266 (25%), Positives = 109/266 (40%), Gaps = 14/266 (5%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIK-TLKPGTMSPEAFLQEAQVMKKLRHEKL 325 + + +LG G FG V T T A K + P E +E Q M LRH L Sbjct: 157 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLRHPTL 216 Query: 326 VQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN 384 V L+ ++ + ++ E+MS G L + + E K + + V+ Q+ G+ ++ N Sbjct: 217 VNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNK-MSEDEAVEYMRQVCKGLCHMHENN 275 Query: 385 YVHRDLRAANILVG--ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 YVH DL+ NI+ + K+ DFGL ++ + ++ APE A Sbjct: 276 YVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVK--VTTGTAEFAAPEVAEGKPV 333 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER---GYRMPCPPECPESLHDLMC 499 +D+WS G+L L + G P+ G + E L V+ E D + Sbjct: 334 GYYTDMWSVGVLSYILLS-GLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGKDFIR 392 Query: 500 QCWRKEPEERPTFEYLQAFLEDYFTS 525 + +P R T QA + T Sbjct: 393 KLLLADPNTRMTIH--QALEHPWLTP 416 >6BXI-A nrPDB Length = 333 Score = 208 bits (530), Expect = 4e-54, Method: Composition-based stats. Identities = 59/310 (19%), Positives = 116/310 (37%), Gaps = 54/310 (17%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEA----FLQEAQVMKKLRH 322 E +G+G FGEV + T V A+K L+ M + E ++ + Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEADS 65 Query: 323 EKLVQ-LYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381 +V+ Y+ + +Y++ E++ G ++ L + L + A+ + + Sbjct: 66 LWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKD--TLTEEETQFYIAETVLAIDSIH 123 Query: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ------------------ 423 ++ ++HRD++ N+L+ K++DFGL ++ T Sbjct: 124 QLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNS 183 Query: 424 ----------------GAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYP 467 + APE + + D WS G+++ E+ G P+ Sbjct: 184 KRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEML-IGYPPFC 242 Query: 468 GMVNREVLDQVER-GYRMPCPPECP--ESLHDLMCQ-CWRKEPEER---PTFEYLQAFLE 520 +E +V + PPE P E DL+ + C E E R P E +++ Sbjct: 243 SETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCC--EWEHRIGAPGVEEIKS--N 298 Query: 521 DYFTSTEPQY 530 +F + ++ Sbjct: 299 SFFEGVDWEH 308 >3C51-A nrPDB Length = 543 Score = 208 bits (530), Expect = 4e-54, Method: Composition-based stats. Identities = 61/271 (22%), Positives = 120/271 (44%), Gaps = 15/271 (5%) Query: 256 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP----EAF 310 Q +A + + LG+G FGEV+ T + A K L + + Sbjct: 173 QWKWLEAQPMGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGA 232 Query: 311 LQEAQVMKKLRHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKG--ETGKYLRLPQLV 367 + E +++ K+ +V L YA ++ + +V M+ G + + E + P+ + Sbjct: 233 MVEKKILAKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRAI 292 Query: 368 DMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKF 427 AQI SG+ ++ + N ++RDL+ N+L+ ++ +++D GLA ++ + T +G Sbjct: 293 FYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQ-TKTKGYAG 351 Query: 428 PIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPY----PGMVNREVLDQVERGYR 483 + APE L + D ++ G+ L E+ R P+ + N+E+ +V Sbjct: 352 TPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAA-RGPFRARGEKVENKELKQRVLE-QA 409 Query: 484 MPCPPECPESLHDLMCQCWRKEPEERPTFEY 514 + P + + D +K+PE+R F Sbjct: 410 VTYPDKFSPASKDFCEALLQKDPEKRLGFRD 440 >3VN9-A nrPDB Length = 340 Score = 208 bits (530), Expect = 4e-54, Method: Composition-based stats. Identities = 67/281 (23%), Positives = 120/281 (42%), Gaps = 20/281 (7%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLK--PGTMSPEAFLQEAQV-MK 318 +E+ + L ++LG+G +G V + ++ A+K ++ + + L + + M+ Sbjct: 46 FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR 105 Query: 319 KLRHEKLVQLYAV-VSEEPIYIVTEYMSKGSLLDFLKG--ETGKYLRLPQLVDMAAQIAS 375 + V Y E ++I E M SL F K + G+ + L +A I Sbjct: 106 TVDCPFTVTFYGALFREGDVWICMELMDT-SLDKFYKQVIDKGQTIPEDILGKIAVSIVK 164 Query: 376 GMAYVERM-NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 434 + ++ + +HRD++ +N+L+ K+ DFG++ + D+ P + AP Sbjct: 165 ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKP--YMAP 222 Query: 435 EAA----LYGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQVERGYRMPCP-P 488 E +++KSD+WS GI + EL R PY + L QV P Sbjct: 223 ERINPELNQKGYSVKSDIWSLGITMIELAIL-RFPYDSWGTPFQQLKQVVEEPSPQLPAD 281 Query: 489 ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 + D QC +K +ERPT+ L +FT E + Sbjct: 282 KFSAEFVDFTSQCLKKNSKERPTYPELMQ--HPFFTLHESK 320 >2Y4I-B nrPDB Length = 319 Score = 208 bits (530), Expect = 4e-54, Method: Composition-based stats. Identities = 78/307 (25%), Positives = 127/307 (41%), Gaps = 26/307 (8%) Query: 247 VCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL---KPG 303 P QT ++ W+IP E L + +G+G FG+V+ G W+G VAI+ + + Sbjct: 13 SFPRKASQTSIFLQE-WDIPFEQLEIGELIGKGRFGQVYHGRWHG--EVAIRLIDIERDN 69 Query: 304 TMSPEAFLQEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLR 362 +AF +E ++ RHE +V S + I+T +L ++ + L Sbjct: 70 EDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVR-DAKIVLD 128 Query: 363 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTAR 422 + + +A +I GM Y+ +H+DL++ N+ N + DFGL I R Sbjct: 129 VNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFS-ISGVLQAGR 186 Query: 423 QGAKFPI--KW---TAPEAALY---------GRFTIKSDVWSFGILLTELTTKGRVPYPG 468 + K I W APE F+ SDV++ G + EL + P+ Sbjct: 187 REDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAR-EWPFKT 245 Query: 469 MVNREVLDQVERGYRMPCPP-ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE 527 ++ Q+ G + + + D++ CW E EERPTF L LE Sbjct: 246 QPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNR 305 Query: 528 PQYQPGE 534 PG Sbjct: 306 RLSHPGH 312 >5Z33-A nrPDB Length = 425 Score = 207 bits (528), Expect = 7e-54, Method: Composition-based stats. Identities = 77/311 (24%), Positives = 118/311 (37%), Gaps = 51/311 (16%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKP---GTMSPEAFLQEAQVMKKL 320 I E + +LGQG +G V N T+ VAIK + + + L+E ++++ Sbjct: 28 IVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFSKKILAKRALREIKLLQHF 87 Query: 321 R-HEKLVQLYAVVSEEP-----IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 374 R H + LY + P Y+ E M L ++ G+ L QI Sbjct: 88 RGHRNITCLYDMDIPRPDNFNETYLYEELMEC-DLAAIIRS--GQPLTDAHFQSFIYQIL 144 Query: 375 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR--LIEDNEYTARQGAKFPIKW- 431 G+ Y+ N +HRDL+ N+LV + K+ DFGLAR ++ E +W Sbjct: 145 CGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYVATRWY 204 Query: 432 TAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP----- 485 APE L + +T DVWS G +L EL GR + G + L+Q+ P Sbjct: 205 RAPEIMLSFQSYTKAIDVWSVGCILAELL-GGRPFFKGRDYVDQLNQILHILGTPNEETL 263 Query: 486 -------------------------CPPECPESLHDLMCQCWRKEPEERPTFEY--LQAF 518 P DL+ + +P R + E + Sbjct: 264 SRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALEHPY 323 Query: 519 LEDY-FTSTEP 528 L + S EP Sbjct: 324 LHIWHDASDEP 334 >1KOA-A nrPDB Length = 491 Score = 207 bits (527), Expect = 9e-54, Method: Composition-based stats. Identities = 68/266 (25%), Positives = 109/266 (40%), Gaps = 14/266 (5%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIK-TLKPGTMSPEAFLQEAQVMKKLRHEKL 325 + + +LG G FG V T T A K + P E +E Q M LRH L Sbjct: 51 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLRHPTL 110 Query: 326 VQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN 384 V L+ ++ + ++ E+MS G L + + E K + + V+ Q+ G+ ++ N Sbjct: 111 VNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNK-MSEDEAVEYMRQVCKGLCHMHENN 169 Query: 385 YVHRDLRAANILVG--ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 YVH DL+ NI+ + K+ DFGL ++ + ++ APE A Sbjct: 170 YVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVK--VTTGTAEFAAPEVAEGKPV 227 Query: 443 TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER---GYRMPCPPECPESLHDLMC 499 +D+WS G+L L + G P+ G + E L V+ E D + Sbjct: 228 GYYTDMWSVGVLSYILLS-GLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGKDFIR 286 Query: 500 QCWRKEPEERPTFEYLQAFLEDYFTS 525 + +P R T QA + T Sbjct: 287 KLLLADPNTRMTIH--QALEHPWLTP 310 >4QNY-A nrPDB Length = 354 Score = 207 bits (527), Expect = 9e-54, Method: Composition-based stats. Identities = 69/322 (21%), Positives = 115/322 (35%), Gaps = 54/322 (16%) Query: 252 KPQTQGLAKDAWEIPRESLR--LEVKLGQGCFGEVWMGTWN--GTTRVAIKTLKPGTMSP 307 P T+ LA+ E+ R R LE +G G +G V VA+K + Sbjct: 2 MPATKSLAELQAEVCRLDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMKRVNKEIFEE 61 Query: 308 ----EAFLQEAQVMKKLRHEKLVQLYAVVSE------EPIYIVTEYMSKGSLLDFLKGET 357 + L+E +++ + ++ L +++ + YIV + M L L+ Sbjct: 62 VILAKRILREIKLLAHFNDDNIIGLRNILTPEDPENFDHFYIVMDIMET-DLKQVLRS-- 118 Query: 358 GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDN 417 G+ L + Q + + +HRD+ ANILV N K+ DFGLA+ E+N Sbjct: 119 GQELTEAHIQFFIYQALRALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAK--EEN 176 Query: 418 EYTARQGAKFPIKW-TAPEAALYGR-FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVL 475 + ++W APE + + ++ + DVW G +L EL R + G L Sbjct: 177 DQGEYMTDYVTMRWYRAPELVMEDKDYSAQIDVWGIGCILGELL-GSRPLFQGKDRVNQL 235 Query: 476 DQVERGYRMPCPPEC------------------------------PESLHDLMCQCWRKE 505 D++ P + DL+ Sbjct: 236 DKIVDVIGTPSEEDINSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFN 295 Query: 506 PEERPTFEYLQAFLEDYFTSTE 527 P+ R T LQA + Sbjct: 296 PKRRITV--LQAMRHPFLEQLH 315 >4CRS-A nrPDB Length = 341 Score = 207 bits (527), Expect = 9e-54, Method: Composition-based stats. Identities = 67/267 (25%), Positives = 116/267 (43%), Gaps = 15/267 (5%) Query: 257 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTM----SPEAFL 311 +++ ++ + R L +G FG+V + + T + AIK LK G + ++ + Sbjct: 1 SMSQQRFQFNLQDFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLM 60 Query: 312 QEAQVMK---KLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLV 367 E ++ + +RH LV L+A ++E + V EY + G L+ + + P+ V Sbjct: 61 CEKRIFETVNSVRHPFLVNLFACFQTKEHVCFVMEYAAGGDLMMHIHTD---VFSEPRAV 117 Query: 368 DMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKF 427 AA + G+ Y+ V+RDL+ N+L+ K+ADFGL + Sbjct: 118 FYAACVVLGLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGT 177 Query: 428 PIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP 487 P ++ APE +T D W G+L+ E+ G P+PG EV D + + P Sbjct: 178 P-EFLAPEVLTETSYTRAVDWWGLGVLIYEMLV-GESPFPGDDEEEVFDSIVN-DEVRYP 234 Query: 488 PECPESLHDLMCQCWRKEPEERPTFEY 514 +M + R+ PE R Sbjct: 235 RFLSTEAISIMRRLLRRNPERRLGASE 261 >3MIA-A nrPDB Length = 351 Score = 207 bits (527), Expect = 1e-53, Method: Composition-based stats. Identities = 69/304 (22%), Positives = 127/304 (41%), Gaps = 51/304 (16%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTL---KPGTMSPEAFLQEAQVMKKLRHEKL 325 K+GQG FGEV+ T +VA+K + P L+E ++++ L+HE + Sbjct: 19 YEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 Query: 326 VQLYAVVS---------EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 V L + + IY+V ++ L L K L ++ + + +G Sbjct: 79 VNLIEICRTKASPYNRCKGSIYLVFDFCEH-DLAGLLSNVLVK-FTLSEIKRVMQMLLNG 136 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE---DNEYTARQGAKFPIKWTA 433 + Y+ R +HRD++AAN+L+ + V K+ADFGLAR +++ + + Sbjct: 137 LYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRP 196 Query: 434 PEAALYGR-FTIKSDVWSFGILLTELTTKGRV---------------------P--YPGM 469 PE L R + D+W G ++ E+ T+ + P +P + Sbjct: 197 PELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNV 256 Query: 470 VNREVLDQVE--RGYRMPCPPECPESLH-----DLMCQCWRKEPEERPTFEYLQAFLEDY 522 N E+ +++E +G + + DL+ + +P +R + A D+ Sbjct: 257 DNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDD--ALNHDF 314 Query: 523 FTST 526 F S Sbjct: 315 FWSD 318 >2XS0-A nrPDB Length = 386 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 65/319 (20%), Positives = 119/319 (37%), Gaps = 62/319 (19%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKP---GTMSPEAFLQEAQVMKKLRHE 323 + + +G G G V R VAIK L + +E +MK + H+ Sbjct: 26 KRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 85 Query: 324 KLVQLYAVVSEEP-------IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 ++ L V + + +YIV E M +L ++ E L ++ + Q+ G Sbjct: 86 NIIGLLNVFTPQKSLEEFQDVYIVMELMDA-NLCQVIQME----LDHERMSYLLYQMLCG 140 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 + ++ +HRDL+ +NI+V + K+ DFGLAR + + APE Sbjct: 141 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFV--VTRYYRAPEV 198 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP--------- 487 L + D+WS G ++ E+ KG V +PG + + ++V PCP Sbjct: 199 ILGMGYKENVDIWSVGCIMGEMI-KGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPT 257 Query: 488 -----------------PECPESL---------------HDLMCQCWRKEPEERPTFEYL 515 P+ L DL+ + + +R + + Sbjct: 258 VRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEA 317 Query: 516 --QAFLEDYFTSTEPQYQP 532 ++ ++ +E + P Sbjct: 318 LQHPYINVWYDPSEAEAPP 336 >1JNK-A nrPDB Length = 423 Score = 206 bits (525), Expect = 2e-53, Method: Composition-based stats. Identities = 69/364 (18%), Positives = 136/364 (37%), Gaps = 69/364 (18%) Query: 223 FNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFG 282 F+ V+Y +KH + ++ ++ + + + + + L +G G G Sbjct: 24 FDKQVD-VSYIAKH-----YNMSKSKVDNQFYSVEVGDSTFTVLKRYQNL-KPIGSGAQG 76 Query: 283 EVWMGTWNGTTR-VAIKTLKP---GTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEP-- 336 V R VAIK L + +E +MK + H+ ++ L V + + Sbjct: 77 IVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTL 136 Query: 337 -----IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLR 391 +Y+V E M +L ++ E L ++ + Q+ G+ ++ +HRDL+ Sbjct: 137 EEFQDVYLVMELMDA-NLCQVIQME----LDHERMSYLLYQMLCGIKHLHSAGIIHRDLK 191 Query: 392 AANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 451 +NI+V + K+ DFGLAR + + APE L + D+WS Sbjct: 192 PSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV--VTRYYRAPEVILGMGYKENVDIWSV 249 Query: 452 GILLTELTTKGRVPYPGMVNREVLDQVERGYRMPC------------------------- 486 G ++ E+ + ++ +PG + ++V PC Sbjct: 250 GCIMGEM-VRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLT 308 Query: 487 -PPECPESL---------------HDLMCQCWRKEPEERPTFEYL--QAFLEDYFTSTEP 528 P P+SL DL+ + +P +R + + ++ ++ E Sbjct: 309 FPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEV 368 Query: 529 QYQP 532 + P Sbjct: 369 EAPP 372 >3ALO-A nrPDB Length = 327 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 65/280 (23%), Positives = 115/280 (41%), Gaps = 20/280 (7%) Query: 256 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEA---FL 311 + + W+ E L+ ++G+G +G V + ++ A+K ++ E + Sbjct: 10 KISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLM 69 Query: 312 QEAQVMKKLRHEKLVQLYAV-VSEEPIYIVTEYMS--KGSLLDFLKGETGKYLRLPQLVD 368 VM+ +VQ Y E +I E MS ++ + L Sbjct: 70 DLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGK 129 Query: 369 MAAQIASGMAYV-ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKF 427 + + ++ E + +HRD++ +NIL+ + K+ DFG++ + D+ R Sbjct: 130 ITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCR 189 Query: 428 PIKWTAPEAA----LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVN-REVLDQVERGY 482 P + APE + ++SDVWS GI L EL T GR PYP + + L QV +G Sbjct: 190 P--YMAPERIDPSASRQGYDVRSDVWSLGITLYELAT-GRFPYPKWNSVFDQLTQVVKGD 246 Query: 483 RMPCP----PECPESLHDLMCQCWRKEPEERPTFEYLQAF 518 E S + + C K+ +RP ++ L Sbjct: 247 PPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKH 286 >3FI2-A nrPDB Length = 353 Score = 206 bits (524), Expect = 2e-53, Method: Composition-based stats. Identities = 60/259 (23%), Positives = 106/259 (40%), Gaps = 24/259 (9%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKP---GTMSPEAFLQEAQVMKKLRHE 323 + + +G G G V R VAIK L + +E +MK + H+ Sbjct: 24 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHK 83 Query: 324 KLVQLYAVVSEEP-------IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 ++ L V + + +Y+V E M +L ++ E L ++ + Q+ G Sbjct: 84 NIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIQME----LDHERMSYLLYQMLCG 138 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 + ++ +HRDL+ +NI+V + K+ DFGLAR + + APE Sbjct: 139 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYV--VTRYYRAPEV 196 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 L + D+WS G ++ E+ + ++ +PG + ++V P CPE + Sbjct: 197 ILGMGYKENVDIWSVGCIMGEM-VRHKILFPGRDYIDQWNKVIEQLGTP----CPEFMKK 251 Query: 497 LMCQCWRKEPEERPTFEYL 515 L E RP + L Sbjct: 252 LQPTVRNYV-ENRPKYAGL 269 >3E7O-A nrPDB Length = 360 Score = 205 bits (523), Expect = 3e-53, Method: Composition-based stats. Identities = 65/320 (20%), Positives = 113/320 (35%), Gaps = 65/320 (20%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKP---GTMSPEAFLQEAQVMKKLRHE 323 + + +G G G V VA+K L + +E ++K + H+ Sbjct: 22 KRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHK 81 Query: 324 KLVQLYAVVSEEP-------IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 ++ L V + + +Y+V E M +L + E L ++ + Q+ G Sbjct: 82 NIISLLNVFTPQKTLEEFQDVYLVMELMDA-NLCQVIHME----LDHERMSYLLYQMLCG 136 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 + ++ +HRDL+ +NI+V + K+ DFGLAR N + APE Sbjct: 137 IKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYV--VTRYYRAPEV 194 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP----------- 485 L + D+WS G ++ EL KG V + G + + ++V P Sbjct: 195 ILGMGYKENVDIWSVGCIMGEL-VKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQPT 253 Query: 486 -------------------CPPECPES-----------LHDLMCQCWRKEPEERPTFEYL 515 P S DL+ + +P++R + + Sbjct: 254 VRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDE- 312 Query: 516 QAFLEDYFTSTEPQYQPGEN 535 A Y T Y P E Sbjct: 313 -ALRHPYITVW---YDPAEA 328 >4AN9-A nrPDB Length = 301 Score = 204 bits (519), Expect = 8e-53, Method: Composition-based stats. Identities = 66/261 (25%), Positives = 111/261 (42%), Gaps = 12/261 (4%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSP---EAFLQEAQVMKKL 320 E+ + +LG G G V+ + + V + L + P ++E QV+ + Sbjct: 5 ELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC 64 Query: 321 RHEKLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 +V Y S+ I I E+M GSL LK + L ++ + G+ Y Sbjct: 65 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKK--AGRIPEQILGKVSIAVIKGLTY 122 Query: 380 V-ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438 + E+ +HRD++ +NILV K+ DFG++ + D G + + +PE Sbjct: 123 LREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMANEFVGTRS---YMSPERLQ 179 Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE-CPESLHDL 497 ++++SD+WS G+ L E+ GR P P M E+LD + P D Sbjct: 180 GTHYSVQSDIWSMGLSLVEMAV-GRYPRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDF 238 Query: 498 MCQCWRKEPEERPTFEYLQAF 518 + +C K P ER + L Sbjct: 239 VNKCLIKNPAERADLKQLMVH 259 >5LPV-A nrPDB Length = 296 Score = 204 bits (519), Expect = 9e-53, Method: Composition-based stats. Identities = 70/276 (25%), Positives = 118/276 (42%), Gaps = 23/276 (8%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKLVQL 328 + +G G FG+V+ + VAIK L F+ E + + K++H LV L Sbjct: 19 FHNDSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPL 78 Query: 329 YAVVS-EEPIYIVTEYMSKGSLLDFLK--GETGKYLRLPQLVDMAAQIASGMAYVERM-- 383 + +V E+M GSL D L + G L +A A G+A++ Sbjct: 79 LGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCS 138 Query: 384 -NYVHRDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGR 441 + +HRD++++N+L+ ENL +V+DFG+ARL+ + + + + PE R Sbjct: 139 PHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFR 198 Query: 442 FTIKSDVWSFGILLTELTTKGRV---PYPGMVN------REVLDQVERGYRMPCPPECPE 492 + K DV+S+G++L EL T R P G N + ++ + E P Sbjct: 199 CSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPELMKEDPA 258 Query: 493 SLHDLMCQ------CWRKEPEERPTFEYLQAFLEDY 522 +L+ C RPT + A ++ Sbjct: 259 LEIELLQHLKVAVACLDDRAWRRPTMVQVMAMFKEI 294 >5LPZ-A nrPDB Length = 332 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 70/276 (25%), Positives = 118/276 (42%), Gaps = 23/276 (8%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKLVQL 328 + +G G FG+V+ + VAIK L F+ E + + K++H LV L Sbjct: 19 FHNDSLIGSGGFGDVYKAILKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPL 78 Query: 329 YAVVS-EEPIYIVTEYMSKGSLLDFLK--GETGKYLRLPQLVDMAAQIASGMAYVERM-- 383 + +V E+M GSL D L + G L +A A G+A++ Sbjct: 79 LGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCS 138 Query: 384 -NYVHRDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGR 441 + +HRD++++N+L+ ENL +V+DFG+ARL+ + + + + PE R Sbjct: 139 PHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFR 198 Query: 442 FTIKSDVWSFGILLTELTTKGRV---PYPGMVN------REVLDQVERGYRMPCPPECPE 492 + K DV+S+G++L EL T R P G N + ++ + E P Sbjct: 199 CSTKGDVYSYGVVLLELLTGKRPTDSPDFGDNNLVGWVKQHAKLRISDVFDPELMKEDPA 258 Query: 493 SLHDLMCQ------CWRKEPEERPTFEYLQAFLEDY 522 +L+ C RPT + A ++ Sbjct: 259 LEIELLQHLKVAVACLDDRAWRRPTMVQVMAMFKEI 294 >3OZ6-A nrPDB Length = 388 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 71/349 (20%), Positives = 123/349 (35%), Gaps = 88/349 (25%) Query: 264 EIPRESLR---LEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKP---GTMSPEAFLQEAQV 316 + R LR L KLG+G +G VW T V A+K + + + +E + Sbjct: 2 RVDRHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMI 61 Query: 317 MKKLR-HEKLVQLYAVVS---EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQ 372 + +L HE +V L V+ + +Y+V +YM L ++ + + + Q Sbjct: 62 LTELSGHENIVNLLNVLRADNDRDVYLVFDYMET-DLHAVIRANILEPV---HKQYVVYQ 117 Query: 373 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE----------------- 415 + + Y+ +HRD++ +NIL+ KVADFGL+R Sbjct: 118 LIKVIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENT 177 Query: 416 ---DNEYTARQGAKFPIKWTAPEAALYG-RFTIKSDVWSFGILLTELTTKGRVPYPGMVN 471 D++ + APE L ++T D+WS G +L E+ G+ +PG Sbjct: 178 ENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILC-GKPIFPGSST 236 Query: 472 REVLDQVERGYRMPCPP------------------------------------------- 488 L+++ P Sbjct: 237 MNQLERIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKIN 296 Query: 489 ---ECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST--EPQYQP 532 +C E DL+ + + P +R + L+ F S P +P Sbjct: 297 PKADCNEEALDLLDKLLQFNPNKRISAN---DALKHPFVSIFHNPNEEP 342 >3LM0-A nrPDB Length = 327 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 67/287 (23%), Positives = 114/287 (39%), Gaps = 22/287 (7%) Query: 260 KDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPE---AFLQEAQ 315 + + +LG+G F V T + A K LK + L E Sbjct: 21 QSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIA 80 Query: 316 VMKKLRH-EKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373 V++ + +++ L+ V I ++ EY + G + E + + ++ + QI Sbjct: 81 VLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQI 140 Query: 374 ASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIK 430 G+ Y+ + N VH DL+ NIL+ K+ DFG++R I + + Sbjct: 141 LEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKI--GHACELREIMGTPE 198 Query: 431 WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER---GYRMPCP 487 + APE Y T +D+W+ GI+ L T P+ G N+E + + Y Sbjct: 199 YLAPEILNYDPITTATDMWNIGIIAYMLLTH-TSPFVGEDNQETYLNISQVNVDYSEETF 257 Query: 488 PECPESLHDLMCQCWRKEPEERPTFE------YLQAF-LEDYFTSTE 527 + D + K PE+RPT E +LQ + E+ F E Sbjct: 258 SSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEE 304 >4OTD-A nrPDB Length = 341 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 64/255 (25%), Positives = 110/255 (43%), Gaps = 15/255 (5%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTM----SPEAFLQEAQVMK 318 + E + LG+G FG+V + + + + AIK LK G + E+ + E +++ Sbjct: 8 PLTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMCEKRILA 67 Query: 319 KLR---HEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 374 + H LV L+ + E + V EY + G L+ + + P+ + +A + Sbjct: 68 AVTSAGHPFLVNLFGCFQTPEHVCFVMEYSAGGDLMLHIHSD---VFSEPRAIFYSACVV 124 Query: 375 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 434 G+ ++ V+RDL+ N+L+ K+ADFGL + P ++ AP Sbjct: 125 LGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTP-EFLAP 183 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESL 494 E +T D W G+LL E+ G P+PG EV D + + P Sbjct: 184 EVLTDTSYTRAVDWWGLGVLLYEMLV-GESPFPGDDEEEVFDSIVN-DEVRYPRFLSAEA 241 Query: 495 HDLMCQCWRKEPEER 509 +M + R+ PE R Sbjct: 242 IGIMRRLLRRNPERR 256 >3ORP-A nrPDB Length = 311 Score = 202 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 73/268 (27%), Positives = 112/268 (41%), Gaps = 19/268 (7%) Query: 268 ESLRLEVKLGQGCFGEVWMGTW-NGTTRVAIKTLKPG-TMSPE---AFLQEAQVMKKLRH 322 + L LG G EV + VA+K L+ P F +EAQ L H Sbjct: 12 DRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAALNH 71 Query: 323 EKLVQLYAVVSEE----PI-YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 +V +Y E P+ YIV EY+ +L D + E + + +++ A + Sbjct: 72 PAIVAVYDTGEAETPAGPLPYIVMEYVDGVTLRDIVHTEG--PMTPKRAIEVIADACQAL 129 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIED--NEYTARQGAKFPIKWTAPE 435 + + +HRD++ ANI++ KV DFG+AR I D N T ++ +PE Sbjct: 130 NFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTAQYLSPE 189 Query: 436 AALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP---PECPE 492 A +SDV+S G +L E+ T G P+ G V Q R +P Sbjct: 190 QARGDSVDARSDVYSLGCVLYEVLT-GEPPFTGDSPVSVAYQHVREDPIPPSARHEGLSA 248 Query: 493 SLHDLMCQCWRKEPEERP-TFEYLQAFL 519 L ++ + K PE R T ++A L Sbjct: 249 DLDAVVLKALAKNPENRYQTAAEMRADL 276 >4PWN-A nrPDB Length = 274 Score = 202 bits (515), Expect = 3e-52, Method: Composition-based stats. Identities = 68/275 (24%), Positives = 126/275 (45%), Gaps = 22/275 (8%) Query: 263 WEIPRESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTL---KPGTMSPEAFLQEAQVMK 318 L+ ++++G+G F V+ G TT VA L K + F +EA+++K Sbjct: 5 MSNDGRFLKFDIEIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLK 64 Query: 319 KLRHEKLVQLYA-----VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373 L+H +V+ Y V ++ I +VTE M+ G+L +LK K +++ L QI Sbjct: 65 GLQHPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKR--FKVMKIKVLRSWCRQI 122 Query: 374 ASGMAYVERMN--YVHRDLRAANILVGE-NLVCKVADFGLARLIEDNEYTARQGAKFPIK 430 G+ ++ +HRDL+ NI + K+ D GLA L + + + + Sbjct: 123 LKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATL--EKRASFAKSVIGTPE 180 Query: 431 WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVN-REVLDQVERGYRMPCPPE 489 + APE ++ DV++FG+ + E+ T PY N ++ +V G + + Sbjct: 181 FMAPEMY-EEKYDESVDVYAFGMCMLEMATS-EYPYSECQNAAQIYRRVTSGVKPASFDK 238 Query: 490 CP-ESLHDLMCQCWRKEPEERPTFEYL--QAFLED 521 + +++ C R+ +ER + + L AF ++ Sbjct: 239 VAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >2VD5-A nrPDB Length = 412 Score = 202 bits (515), Expect = 3e-52, Method: Composition-based stats. Identities = 63/295 (21%), Positives = 110/295 (37%), Gaps = 20/295 (6%) Query: 232 YYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNG 291 + A L + + + R+ + +G+G F EV + Sbjct: 25 HQELGASELAQDKYVADFLQWAEPIVVRLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQ 84 Query: 292 TTRV-AIKTLKPGTMSPE----AFLQEAQVMKKLRHEKLVQLYAVVSEEP-IYIVTEYMS 345 T +V A+K + M F +E V+ + QL+ +E +Y+V EY Sbjct: 85 TGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQDENYLYLVMEYYV 144 Query: 346 KGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKV 405 G LL L + G+ + A+I + V R+ YVHRD++ NIL+ ++ Sbjct: 145 GGDLLTLL-SKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRL 203 Query: 406 ADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL-------YGRFTIKSDVWSFGILLTEL 458 ADFG + + A + +PE G + + D W+ G+ E+ Sbjct: 204 ADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEM 263 Query: 459 TTKGRVPYPGMVNREVLDQV---ERGYRMPCPPE-CPESLHDLMCQCWRKEPEER 509 G+ P+ E ++ + +P E PE D + + PE R Sbjct: 264 F-YGQTPFYADSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCP-PETR 316 >2A1A-B nrPDB Length = 284 Score = 202 bits (514), Expect = 3e-52, Method: Composition-based stats. Identities = 54/278 (19%), Positives = 111/278 (39%), Gaps = 29/278 (10%) Query: 269 SLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQ 327 + +G G FG+V+ + IK +K E +E + + KL H +V Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNEKAE---REVKALAKLDHVNIVH 68 Query: 328 LYAVVS-----------------EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMA 370 + ++I E+ KG+L +++ G+ L +++ Sbjct: 69 YNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLDKVLALELF 128 Query: 371 AQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIK 430 QI G+ Y+ ++RDL+ +NI + + K+ DFGL ++++ R +K ++ Sbjct: 129 EQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDG--KRTRSKGTLR 186 Query: 431 WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC 490 + +PE + + D+++ G++L EL + + + G Sbjct: 187 YMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFE---TSKFFTDLRDGI---ISDIF 240 Query: 491 PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEP 528 + L+ + K+PE+RP + L + S E Sbjct: 241 DKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEK 278 >3GC0-A nrPDB Length = 329 Score = 202 bits (513), Expect = 4e-52, Method: Composition-based stats. Identities = 63/320 (19%), Positives = 122/320 (38%), Gaps = 47/320 (14%) Query: 245 TTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPG 303 T T P + ++ + R KLG+G +GEV+ T VAIK ++ Sbjct: 11 TLEAQTQGPGSMSVSAAPSATSIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLE 70 Query: 304 TMS---PEAFLQEAQVMKKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGK 359 P ++E ++K+L+H +++L +V+ ++++ EY L ++ Sbjct: 71 HEEEGVPGTAIREVSLLKELQHRNIIELKSVIHHNHRLHLIFEYAEN-DLKKYMDKNPDV 129 Query: 360 YLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILV-----GENLVCKVADFGLARLI 414 +R+ + Q+ +G+ + +HRDL+ N+L+ E V K+ DFGLAR Sbjct: 130 SMRV--IKSFLYQLINGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAF 187 Query: 415 EDNEYTARQGAKFPIKWTAPEAALY-GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNRE 473 + + PE L ++ D+WS + E+ K +PG + Sbjct: 188 -GIPIRQFTHEIITLWYRPPEILLGSRHYSTSVDIWSIACIWAEMLMK-TPLFPGDSEID 245 Query: 474 VLDQVERGYRMP-----------------CPPECPESLHDLM------------CQCWRK 504 L ++ +P P ++L ++ Sbjct: 246 QLFKIFEVLGLPDDTTWPGVTALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEM 305 Query: 505 EPEERPTFEYLQAFLEDYFT 524 +P +R + + A YF+ Sbjct: 306 DPVKRISAKN--ALEHPYFS 323 >2BUJ-A nrPDB Length = 317 Score = 201 bits (512), Expect = 5e-52, Method: Composition-based stats. Identities = 62/295 (21%), Positives = 113/295 (38%), Gaps = 23/295 (7%) Query: 258 LAKDAWEIPRESLRLEVKLGQGCFGEVWMGT-WNGTTRVAIK-TLKPGTMSPEAFLQEAQ 315 I + KLG+G F V + + A+K L E +EA Sbjct: 19 FQGHMVIIDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREAD 78 Query: 316 VMKKLRHEKLVQLYAVV-----SEEPIYIVTEYMSKGSLLDFLKG--ETGKYLRLPQLVD 368 + + H +++L A ++ +++ + +G+L + ++ + G +L Q++ Sbjct: 79 MHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILW 138 Query: 369 MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ----- 423 + I G+ + Y HRDL+ NIL+G+ + D G + +RQ Sbjct: 139 LLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQ 198 Query: 424 ---GAKFPIKWTAPEAALYGRF---TIKSDVWSFGILLTELTTKGRVPYPGMVNR--EVL 475 + I + APE ++DVWS G +L + G PY + + V Sbjct: 199 DWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMM-FGEGPYDMVFQKGDSVA 257 Query: 476 DQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 V+ +P P +L L+ +P +RP L + LE Q+ Sbjct: 258 LAVQNQLSIPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLLSQLEALQPPAPGQH 312 >1NY3-A nrPDB Length = 400 Score = 201 bits (512), Expect = 5e-52, Method: Composition-based stats. Identities = 56/264 (21%), Positives = 102/264 (38%), Gaps = 28/264 (10%) Query: 274 VKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQEAQVM-KKLRHEKLVQLYAV 331 LG G G+V T + A+K L +E ++ + + +V++ V Sbjct: 68 QVLGLGINGKVLQIFNKRTQEKFALKML----QDCPKARREVELHWRASQCPHIVRIVDV 123 Query: 332 VS-----EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 + + IV E + G L ++ + + ++ I + Y+ +N Sbjct: 124 YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIA 183 Query: 387 HRDLRAANILVGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443 HRD++ N+L N + K+ DFG A+ E + + + + APE ++ Sbjct: 184 HRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYTPYYVAPEVLGPEKYD 241 Query: 444 IKSDVWSFGILLTELTTKGRVPY---------PGMVNREVLDQVERGYRMPCPPECPESL 494 D+WS G+++ L G P+ PGM R + Q E + P E E + Sbjct: 242 KSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYE--FPNPEWSEVSEEV 298 Query: 495 HDLMCQCWRKEPEERPTFEYLQAF 518 L+ + EP +R T Sbjct: 299 KMLIRNLLKTEPTQRMTITEFMNH 322 >3VHK-A nrPDB Length = 368 Score = 201 bits (512), Expect = 5e-52, Method: Composition-based stats. Identities = 72/194 (37%), Positives = 105/194 (54%), Gaps = 7/194 (3%) Query: 343 YMSKGSLLDFLKGETGK-----YLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILV 397 ++ + SL D + E + +L L L+ + Q+A GM ++ +HRDL A NIL+ Sbjct: 174 FVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILL 233 Query: 398 GENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLT 456 E V K+ DFGLAR I D +Y + A+ P+KW APE +TI+SDVWSFG+LL Sbjct: 234 SEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLW 293 Query: 457 ELTTKGRVPYPGMV-NREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYL 515 E+ + G PYPG+ + E +++ G RM P ++ M CW EP +RPTF L Sbjct: 294 EIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSEL 353 Query: 516 QAFLEDYFTSTEPQ 529 L + + Q Sbjct: 354 VEHLGNLLQANAQQ 367 Score = 95.4 bits (236), Expect = 5e-20, Method: Composition-based stats. Identities = 36/146 (24%), Positives = 63/146 (43%), Gaps = 17/146 (11%) Query: 257 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR------VAIKTLKPGTMSPE-- 308 WE PR+ L+L LG+G FG+V G + VA+K LK G E Sbjct: 18 PYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHR 77 Query: 309 AFLQEAQVMKKLRHE-KLVQLYAVVSE--EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQ 365 A + E +++ + H +V L ++ P+ ++ E+ G+L +L+ + +++ Sbjct: 78 ALMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKT 137 Query: 366 LVDMAAQIASGMAYVERMNYVHRDLR 391 Q G YV + DL+ Sbjct: 138 KGARFRQ---GKDYVGAIPV---DLK 157 >2OZA-A nrPDB Length = 356 Score = 201 bits (511), Expect = 6e-52, Method: Composition-based stats. Identities = 56/264 (21%), Positives = 102/264 (38%), Gaps = 28/264 (10%) Query: 274 VKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQEAQVM-KKLRHEKLVQLYAV 331 LG G G+V T + A+K L +E ++ + + +V++ V Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKML----QDCPKARREVELHWRASQCPHIVRIVDV 79 Query: 332 VS-----EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 + + IV E + G L ++ + + ++ I + Y+ +N Sbjct: 80 YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIA 139 Query: 387 HRDLRAANILVGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443 HRD++ N+L N + K+ DFG A+ E + + + + APE ++ Sbjct: 140 HRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTTPCYTPYYVAPEVLGPEKYD 197 Query: 444 IKSDVWSFGILLTELTTKGRVPY---------PGMVNREVLDQVERGYRMPCPPECPESL 494 D+WS G+++ L G P+ PGM R + Q E + P E E + Sbjct: 198 KSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYE--FPNPEWSEVSEEV 254 Query: 495 HDLMCQCWRKEPEERPTFEYLQAF 518 L+ + EP +R T Sbjct: 255 KMLIRNLLKTEPTQRMTITEFMNH 278 >1ZXE-A nrPDB Length = 303 Score = 201 bits (511), Expect = 6e-52, Method: Composition-based stats. Identities = 59/282 (20%), Positives = 104/282 (36%), Gaps = 38/282 (13%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLV 326 LGQG FG+V + AIK ++ L E ++ L H+ +V Sbjct: 6 SDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQYVV 65 Query: 327 QLYA--------------VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQ 372 + YA V + ++I EY +L D + E R + + Q Sbjct: 66 RYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQR-DEYWRLFRQ 124 Query: 373 IASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-------------DNEY 419 I ++Y+ +HR+L+ NI + E+ K+ DFGLA+ + Sbjct: 125 ILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLDSQNLPGSS 184 Query: 420 TARQGAKFPIKWTAPEAALY-GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 A + A E G + K D++S GI+ E+ P+ + R + + Sbjct: 185 DNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY----PFSTGMERVNILKK 240 Query: 479 ERGYRMPCPPECPESL----HDLMCQCWRKEPEERPTFEYLQ 516 R + PP+ ++ ++ +P +RP L Sbjct: 241 LRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLL 282 >3KA0-A nrPDB Length = 320 Score = 200 bits (510), Expect = 9e-52, Method: Composition-based stats. Identities = 56/264 (21%), Positives = 102/264 (38%), Gaps = 28/264 (10%) Query: 274 VKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQEAQVM-KKLRHEKLVQLYAV 331 LG G G+V T + A+K L +E ++ + + +V++ V Sbjct: 22 QVLGLGINGKVLQIFNKRTQEKFALKML----QDCPKARREVELHWRASQCPHIVRIVDV 77 Query: 332 VS-----EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 + + IV E + G L ++ + + ++ I + Y+ +N Sbjct: 78 YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIA 137 Query: 387 HRDLRAANILVGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443 HRD++ N+L N + K+ DFG A+ E + + + + APE ++ Sbjct: 138 HRDVKPENLLYTSKRPNAILKLTDFGFAK--ETTSHNSLTEPCYTPYYVAPEVLGPEKYD 195 Query: 444 IKSDVWSFGILLTELTTKGRVPY---------PGMVNREVLDQVERGYRMPCPPECPESL 494 D+WS G+++ L G P+ PGM R + Q E + P E E + Sbjct: 196 KSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYE--FPNPEWSEVSEEV 252 Query: 495 HDLMCQCWRKEPEERPTFEYLQAF 518 L+ + EP +R T Sbjct: 253 KMLIRNLLKTEPTQRMTITEFMNH 276 >5Y86-A nrPDB Length = 588 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 55/244 (22%), Positives = 101/244 (41%), Gaps = 20/244 (8%) Query: 264 EIPRESL----RLEVKLGQGCFGEVWMGT-WNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 318 +PR+ L + +G+G FG+V VA+K ++ +E ++++ Sbjct: 199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILE 258 Query: 319 KLRHE------KLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA 371 L+ + ++ + + + + E +S L + +K + + + A Sbjct: 259 HLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSI-DLYELIKKNKFQGFSVQLVRKFAQ 317 Query: 372 QIASGMAYVERMNYVHRDLRAANILVGENL--VCKVADFGLARLIEDNEYTARQGAKFPI 429 I + + + +H DL+ NIL+ + KV DFG + YT Q Sbjct: 318 SILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSR---- 373 Query: 430 KWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE 489 + APE L R++ D+WSFG +L EL T G+ +PG + L + MP P Sbjct: 374 FYRAPEIILGSRYSTPIDIWSFGCILAELLT-GQPLFPGEDEGDQLACMMELLGMPPPKL 432 Query: 490 CPES 493 +S Sbjct: 433 LEQS 436 >3REP-A nrPDB Length = 271 Score = 199 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 69/272 (25%), Positives = 119/272 (43%), Gaps = 22/272 (8%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKP---GTMSPEAFLQEAQVMKKL 320 I + L KL + GE+W G W G V +K LK T F +E ++ Sbjct: 6 GIDFKQLNFLTKLNENHSGELWKGRWQGNDIV-VKVLKVRDWSTRKSRDFNEECPRLRIF 64 Query: 321 RHEKLVQLYAVVSEEPI---YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 H ++ + P ++T +M GSL + L T + Q V A +A GM Sbjct: 65 SHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGM 124 Query: 378 AYVERMNYV--HRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ-GAKFPIKWTAP 434 A++ + + L + ++++ E++ +++ + D +++ + G + W AP Sbjct: 125 AFLHTLEPLIPRHALNSRSVMIDEDMTARIS-------MADVKFSFQSPGRMYAPAWVAP 177 Query: 435 EAALYGRFTI---KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPEC 490 EA +D+WSF +LL EL T+ VP+ + N E+ +V G R PP Sbjct: 178 EALQKKPEDTNRRSADMWSFAVLLWELVTR-EVPFADLSNMEIGMKVALEGLRPTIPPGI 236 Query: 491 PESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 + LM C ++P +RP F+ + LE Sbjct: 237 SPHVSKLMKICMNEDPAKRPKFDMIVPILEKM 268 >3FXW-A nrPDB Length = 336 Score = 199 bits (506), Expect = 3e-51, Method: Composition-based stats. Identities = 59/288 (20%), Positives = 104/288 (36%), Gaps = 41/288 (14%) Query: 256 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSPEAFLQEA 314 QG + + + + LG G G+V T + A+K L + + Sbjct: 17 QGPEPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLLYDSPKARQE----- 71 Query: 315 QVMKKLRH-------EKLVQLYAVVS-----EEPIYIVTEYMSKGSLLDFLKGETGKYLR 362 + H +V + V + + I+ E M G L ++ + Sbjct: 72 -----VDHHWQASGGPHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFT 126 Query: 363 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE---NLVCKVADFGLARLIEDNEY 419 + ++ I + + ++ N HRD++ N+L + V K+ DFG A+ + Sbjct: 127 EREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAK---ETTQ 183 Query: 420 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPY---------PGMV 470 A Q + + APE ++ D+WS G+++ L G P+ PGM Sbjct: 184 NALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLC-GFPPFYSNTGQAISPGMK 242 Query: 471 NREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAF 518 R L Q G+ P E E L+ + +P ER T Sbjct: 243 RRIRLGQY--GFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNH 288 >4E7W-A nrPDB Length = 394 Score = 199 bits (505), Expect = 4e-51, Method: Composition-based stats. Identities = 58/288 (20%), Positives = 107/288 (37%), Gaps = 46/288 (15%) Query: 274 VKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS 333 +G G FG V+ + VAIK + +E Q+M+ ++H +V L A Sbjct: 46 KVIGNGSFGVVFQAKLVESDEVAIKKVLQDKRFKN---RELQIMRIVKHPNVVDLKAFFY 102 Query: 334 EEP-------IYIVTEYMSKGSLL-DFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 + +V EY+ + + + + + + Q+ +AY+ + Sbjct: 103 SNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMYQLLRSLAYIHSIGI 162 Query: 386 VHRDLRAANILVG-ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALY-GRFT 443 HRD++ N+L+ + V K+ DFG A+++ E + APE +T Sbjct: 163 CHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYIC--SRYYRAPELIFGATNYT 220 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP------------------ 485 D+WS G ++ EL +G+ +PG + L ++ + P Sbjct: 221 TNIDIWSTGCVMAELM-QGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEHKFP 279 Query: 486 ----------CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 P P DL+ + P R T ++A +F Sbjct: 280 QIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTA--IEALCHPFF 325 >4ZSG-A nrPDB Length = 347 Score = 198 bits (504), Expect = 4e-51, Method: Composition-based stats. Identities = 63/312 (20%), Positives = 116/312 (37%), Gaps = 52/312 (16%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPG---TMSPEAFLQEAQVMKKLRHE 323 + + +G G +G V T + VAIK + + + L+E +++K +H+ Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 66 Query: 324 KLVQLYAVVSE-------EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 ++ + ++ + +Y+V + M L + + L L + Q+ G Sbjct: 67 NIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHS--SQPLTLEHVRYFLYQLLRG 123 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKW-TA 433 + Y+ +HRDL+ +N+LV EN K+ DFG+AR + E+ +W A Sbjct: 124 LKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRA 183 Query: 434 PEAALY-GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP----- 487 PE L +T D+WS G + E+ + ++ +PG L + P P Sbjct: 184 PELMLSLHEYTQAIDLWSVGCIFGEMLARRQL-FPGKNYVHQLQLIMMVLGTPSPAVIQA 242 Query: 488 -------------------------PECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 P L+ + R EP R + A + Sbjct: 243 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAA--ALRHPF 300 Query: 523 FTS-TEPQYQPG 533 +P +P Sbjct: 301 LAKYHDPDDEPD 312 >4IC8-A nrPDB Length = 442 Score = 198 bits (504), Expect = 4e-51, Method: Composition-based stats. Identities = 63/312 (20%), Positives = 116/312 (37%), Gaps = 52/312 (16%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPG---TMSPEAFLQEAQVMKKLRHE 323 + + +G G +G V T + VAIK + + + L+E +++K +H+ Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHD 114 Query: 324 KLVQLYAVVSE-------EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 ++ + ++ + +Y+V + M L + + L L + Q+ G Sbjct: 115 NIIAIKDILRPTVPYGEFKSVYVVLDLME-SDLHQIIHS--SQPLTLEHVRYFLYQLLRG 171 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLI--EDNEYTARQGAKFPIKW-TA 433 + Y+ +HRDL+ +N+LV EN K+ DFG+AR + E+ +W A Sbjct: 172 LKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRA 231 Query: 434 PEAALY-GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP----- 487 PE L +T D+WS G + E+ + ++ +PG L + P P Sbjct: 232 PELMLSLHEYTQAIDLWSVGCIFGEMLARRQL-FPGKNYVHQLQLIMMVLGTPSPAVIQA 290 Query: 488 -------------------------PECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 P L+ + R EP R + A + Sbjct: 291 VGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAA--ALRHPF 348 Query: 523 FTS-TEPQYQPG 533 +P +P Sbjct: 349 LAKYHDPDDEPD 360 >5O2B-A nrPDB Length = 285 Score = 198 bits (504), Expect = 5e-51, Method: Composition-based stats. Identities = 65/263 (24%), Positives = 116/263 (44%), Gaps = 21/263 (7%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTL---KPGTMSPEAFLQEAQVMKKLRHEKL 325 L+ +++LG+G F V+ G T VA L K + F +EA+++K L+H + Sbjct: 18 LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNI 77 Query: 326 VQLYAVVS-----EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 V+ Y ++ I +VTE M+ G+L +LK K ++ L QI G+ ++ Sbjct: 78 VRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKR--FKVMKPKVLRSWCRQILKGLQFL 135 Query: 381 ERMN--YVHRDLRAANILVGE-NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 437 +HRDL+ NI + K+ D GLA L+ + + ++ APE Sbjct: 136 HTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRT---SFAKSVIGTPEFMAPEMY 192 Query: 438 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVN-REVLDQVERGYRMPCPPECP-ESLH 495 + DV++FG+ + E+ T PY N ++ +V G + + + Sbjct: 193 -EEHYDESVDVYAFGMCMLEMATS-EYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVK 250 Query: 496 DLMCQCWRKEPEERPTFEYLQAF 518 +++ C R+ ER + L Sbjct: 251 EIIEGCIRQNKSERLSIRDLLNH 273 >3UIU-A nrPDB Length = 306 Score = 198 bits (503), Expect = 5e-51, Method: Composition-based stats. Identities = 52/290 (17%), Positives = 111/290 (38%), Gaps = 40/290 (13%) Query: 269 SLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL 328 + +G G FG+V+ + + ++ + E +E + + KL H +V Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYV--IRRVKYNNEKAEREVKALAKLDHVNIVHY 70 Query: 329 YAVVS------------------------------EEPIYIVTEYMSKGSLLDFLKGETG 358 + ++I E+ KG+L +++ G Sbjct: 71 NGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRG 130 Query: 359 KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE 418 + L +++ QI G+ Y+ +HRDL+ +NI + + K+ DFGL ++++ Sbjct: 131 EKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDG 190 Query: 419 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 R +K +++ +PE + + D+++ G++L EL + + + Sbjct: 191 --KRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELLHVCDTAFE---TSKFFTDL 245 Query: 479 ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEP 528 G + L+ + K+PE+RP + L + S E Sbjct: 246 RDGI---ISDIFDKKEKTLLQKLLSKKPEDRPNTSEILRTLTVWKKSPEK 292 >5O2C-A nrPDB Length = 380 Score = 197 bits (502), Expect = 8e-51, Method: Composition-based stats. Identities = 65/263 (24%), Positives = 116/263 (44%), Gaps = 21/263 (7%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTL---KPGTMSPEAFLQEAQVMKKLRHEKL 325 L+ +++LG+G F V+ G T VA L K + F +EA+++K L+H + Sbjct: 27 LKFDIELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHPNI 86 Query: 326 VQLYAVVS-----EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 V+ Y ++ I +VTE M+ G+L +LK K ++ L QI G+ ++ Sbjct: 87 VRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKR--FKVMKPKVLRSWCRQILKGLQFL 144 Query: 381 ERMN--YVHRDLRAANILVGE-NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 437 +HRDL+ NI + K+ D GLA L+ + + ++ APE Sbjct: 145 HTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRT---SFAKSVIGTPEFMAPEMY 201 Query: 438 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVN-REVLDQVERGYRMPCPPECP-ESLH 495 + DV++FG+ + E+ T PY N ++ +V G + + + Sbjct: 202 -EEHYDESVDVYAFGMCMLEMATS-EYPYSECQNAAQIYRKVTSGIKPASFNKVTDPEVK 259 Query: 496 DLMCQCWRKEPEERPTFEYLQAF 518 +++ C R+ ER + L Sbjct: 260 EIIEGCIRQNKSERLSIRDLLNH 282 >3PVW-A nrPDB Length = 695 Score = 197 bits (501), Expect = 9e-51, Method: Composition-based stats. Identities = 57/284 (20%), Positives = 113/284 (39%), Gaps = 25/284 (8%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEA----FLQEAQVMK 318 + + +G+G FGEV+ T + A+K L + + L E ++ Sbjct: 185 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 244 Query: 319 KL---RHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 374 + +V + YA + + + + + M+ G L L + AA+I Sbjct: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYAAEII 302 Query: 375 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 434 G+ ++ V+RDL+ ANIL+ E+ +++D GLA + A G + AP Sbjct: 303 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG---YMAP 359 Query: 435 EAALYG-RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREV--LDQVERGYRMPCPPECP 491 E G + +D +S G +L +L +G P+ ++ +D++ + P Sbjct: 360 EVLQKGVAYDSSADWFSLGCMLFKLL-RGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFS 418 Query: 492 ESLHDLMCQCWRKEPEERP-----TFEYLQAFLEDYFTSTEPQY 530 L L+ +++ R + ++ +F S + Q Sbjct: 419 PELRSLLEGLLQRDVNRRLGCLGRGAQEVKE--SPFFRSLDWQM 460 >4M7I-A nrPDB Length = 299 Score = 197 bits (501), Expect = 1e-50, Method: Composition-based stats. Identities = 62/288 (21%), Positives = 110/288 (38%), Gaps = 39/288 (13%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLK--PGTMSPEAFLQEAQVMKKLRHEK 324 LG+G FG V+ AIK ++ ++ E ++E + + KL H Sbjct: 5 TDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPG 64 Query: 325 LVQLYAVVSEEP-------------IYIVTEYMSKGSLLDFLKGETGKYLRLPQL-VDMA 370 +V+ + E+ +YI + K +L D++ G R + + + Sbjct: 65 IVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIF 124 Query: 371 AQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNE-----------Y 419 QIA + ++ +HRDL+ +NI + V KV DFGL ++ +E Y Sbjct: 125 LQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAY 184 Query: 420 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE 479 G + +PE ++ K D++S G++L EL YP E + + Sbjct: 185 ARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL------YPFSTQMERVRTLT 238 Query: 480 RGYRMPCPPECPESL---HDLMCQCWRKEPEERPTFEYLQA--FLEDY 522 + PP + + ++ P ERP + ED Sbjct: 239 DVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDL 286 >5UUU-A nrPDB Length = 547 Score = 197 bits (501), Expect = 1e-50, Method: Composition-based stats. Identities = 57/284 (20%), Positives = 113/284 (39%), Gaps = 25/284 (8%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEA----FLQEAQVMK 318 + + +G+G FGEV+ T + A+K L + + L E ++ Sbjct: 194 HLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLS 253 Query: 319 KL---RHEKLVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 374 + +V + YA + + + + + M+ G L L + AA+I Sbjct: 254 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRFYAAEII 311 Query: 375 SGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 434 G+ ++ V+RDL+ ANIL+ E+ +++D GLA + A G + AP Sbjct: 312 LGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHG---YMAP 368 Query: 435 EAALYG-RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREV--LDQVERGYRMPCPPECP 491 E G + +D +S G +L +L +G P+ ++ +D++ + P Sbjct: 369 EVLQKGVAYDSSADWFSLGCMLFKLL-RGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFS 427 Query: 492 ESLHDLMCQCWRKEPEERP-----TFEYLQAFLEDYFTSTEPQY 530 L L+ +++ R + ++ +F S + Q Sbjct: 428 PELRSLLEGLLQRDVNRRLGCLGRGAQEVKE--SPFFRSLDWQM 469 >6AMW-A nrPDB Length = 255 Score = 197 bits (501), Expect = 1e-50, Method: Composition-based stats. Identities = 81/253 (32%), Positives = 125/253 (49%), Gaps = 16/253 (6%) Query: 13 QRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDT 72 QRR SL + GAG P A P A++ + G ++ Sbjct: 12 QRRPSLPALHFIKGAGKRESSRHGGPHCNV----FVEHEALQRPVASDFEPQGLSEAARW 67 Query: 73 VTSPQR-AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVN-NTEGDWWLAHSLSTG 130 + AGP FVALYD+ + + LS KGE+L+++ N G+W A + G Sbjct: 68 NSKENLLAGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWAEAQT-KNG 126 Query: 131 QTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLS 190 Q G++PSNY+ P +S++ WY G ++R +E LL + N G+FLVRESE++ G +S Sbjct: 127 Q-GWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSIS 183 Query: 191 VSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCP- 249 + V HY+I G Y++S ++FN+L +LV ++S ADGL L P Sbjct: 184 LR-----YEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPK 238 Query: 250 TSKPQTQGLAKDA 262 +KP G++ + Sbjct: 239 RNKPTVYGVSPNY 251 >5ZTN-A nrPDB Length = 429 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 53/244 (21%), Positives = 98/244 (40%), Gaps = 18/244 (7%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHE--- 323 + +G+G FG+V + + VA+K ++ +E ++++ LR + Sbjct: 97 YRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKD 156 Query: 324 ---KLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 ++ + + I + E +S +L + +K + LP + A I + Sbjct: 157 NTMNVIHMLENFTFRNHICMTFELLSM-NLYELIKKNKFQGFSLPLVRKFAHSILQCLDA 215 Query: 380 VERMNYVHRDLRAANILVGENLV--CKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 437 + + +H DL+ NIL+ + KV DFG + YT Q + APE Sbjct: 216 LHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSR----FYRAPEVI 271 Query: 438 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP--ECPESLH 495 L R+ + D+WS G +L EL T G PG + L + MP + + Sbjct: 272 LGARYGMPIDMWSLGCILAELLT-GYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAK 330 Query: 496 DLMC 499 + + Sbjct: 331 NFVS 334 >4O2Z-A nrPDB Length = 377 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 63/304 (20%), Positives = 113/304 (37%), Gaps = 47/304 (15%) Query: 256 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLK---PGTMSPEAFL 311 ++ +E+P L LG G +G T +V+IK + + L Sbjct: 34 YNVSGSPFEVP-SKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGKRVL 92 Query: 312 QEAQVMKKLRHEKLVQLYAVVSE--------EPIYIVTEYMSKGSLLDFLKGETGKYLRL 363 +E +M+ HE L+ + ++ E +Y+VT M + + + + L Sbjct: 93 REIDMMRFFHHENLLNVVNILPPLKREYHSFEDVYVVTPLM---DVDMNVVLRSRQVLEE 149 Query: 364 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 423 + QI G+ Y+ N HRDL+ AN++ + K+ DFGL+R + D Y+ Sbjct: 150 SHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSV-DVPYSELT 208 Query: 424 GAKFPIKWTAPEAALYG-RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY 482 + PE L ++ D+WS G + E+ + + +PG + L + + Sbjct: 209 DYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNR-KPVFPGRNTMDQLRMIAQHI 267 Query: 483 RMP-----------------------CPPECP-----ESLHDLMCQCWRKEPEERPTFEY 514 P P P D + + W +P +RPT Sbjct: 268 GKPPASIVEHREALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAAD 327 Query: 515 LQAF 518 + A Sbjct: 328 MLAH 331 >5XD6-A nrPDB Length = 305 Score = 196 bits (499), Expect = 2e-50, Method: Composition-based stats. Identities = 75/277 (27%), Positives = 118/277 (42%), Gaps = 29/277 (10%) Query: 276 LGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE 335 +G+G +G V+ G AIK L + FL + ++ +LR E +V L + Sbjct: 30 IGEGSYGRVFYGILKSGKAAAIKKLDSSKQPDQEFLAQVSMVSRLRQENVVALLGYCVDG 89 Query: 336 PI-YIVTEYMSKGSLLDFLKGET-------GKYLRLPQLVDMAAQIASGMAYVERM---N 384 P+ + EY GSL D L G G L Q V +A A G+ Y+ + Sbjct: 90 PLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAARGLEYLHEKANPH 149 Query: 385 YVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK-FPIKWTAPEAALYGRFT 443 +HRD++++N+L+ ++ V K+ADF L+ D + APE A+ G + Sbjct: 150 VIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAARLHSTRVLGTFGYHAPEYAMTGTLS 209 Query: 444 IKSDVWSFGILLTELTTKGRVP----------------YPGMVNREVLDQVERGYRMPCP 487 KSDV+SFG++L EL T GR P P + +V V+ P Sbjct: 210 TKSDVYSFGVVLLELLT-GRKPVDHTLPRGQQSVVTWATPKLSEDKVKQCVDARLNGEYP 268 Query: 488 PECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFT 524 P+ L + C + E + RP + L+ Sbjct: 269 PKAVAKLAAVAALCVQYEADFRPNMSIVVKALQPLLN 305 >4BTF-A nrPDB Length = 469 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 68/306 (22%), Positives = 134/306 (43%), Gaps = 21/306 (6%) Query: 241 CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLE-VKLGQGCFGEVWMGTWNGTTRVAIKT 299 ++ C Q EIP+E L KL ++ G ++ + V IK Sbjct: 167 INKTLKQCSLKPTQEIPQDLQIKEIPKEHLGPPWTKLKTSKMSTIYRGEYH-RSPVTIKV 225 Query: 300 LKPGTMSPEAFLQ-----EAQVMKKLRHEKLVQLYAVVSEE-----PIYIVTEYMSKGSL 349 ++ E + MKK +++++ + ++ IV EY G+L Sbjct: 226 FNNPQAESVGIVRFTFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTL 285 Query: 350 LDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFG 409 + L E + + L+ + A A G+ + +HR++ +++ LV K+A F Sbjct: 286 RELLDREKDLTMSVRSLLVLRA--ARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFE 343 Query: 410 LARLIEDNEYTARQG---AKFPIKWTAPEAALY--GRFTIKSDVWSFGILLTELTTKGRV 464 L++ TA+ + +PE + IK++++SFGI+L E+ T G++ Sbjct: 344 LSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIAT-GKI 402 Query: 465 PYPGMVNREVLDQV-ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 P+ G ++++ + V E + P +CPE L +++ +C EP +RP+ + + L Sbjct: 403 PFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILERLSAVE 462 Query: 524 TSTEPQ 529 ST+ + Sbjct: 463 ESTDKK 468 >2ABL-A nrPDB Length = 163 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 64/171 (37%), Positives = 97/171 (56%), Gaps = 10/171 (5%) Query: 80 GPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVN-NTEGDWWLAHSLSTGQTGYIPSN 138 GP FVALYD+ + + LS KGE+L+++ N G+W A + GQ G++PSN Sbjct: 2 GPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT-KNGQ-GWVPSN 59 Query: 139 YVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAK 198 Y+ P +S++ WY G ++R +E LL + N G+FLVRESE++ G +S+ Sbjct: 60 YITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR-----Y 112 Query: 199 GLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCP 249 V HY+I G Y++S ++FN+L +LV ++S ADGL L P Sbjct: 113 EGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAP 163 >5TQX-A nrPDB Length = 655 Score = 194 bits (494), Expect = 7e-50, Method: Composition-based stats. Identities = 69/275 (25%), Positives = 112/275 (40%), Gaps = 39/275 (14%) Query: 271 RLEVKLGQGCFGEVWMGTWNG-TTRVAIK--TLKPGTMSPEAFLQEAQVMKKLRHEKLVQ 327 + +LG G FG V + ++AIK L+ T + E + E Q+MKKL H +V+ Sbjct: 11 EMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVVK 70 Query: 328 LYAVVSEEPIYI------VTEYMSKGSLLDFL-KGETGKYLRLPQLVDMAAQIASGMAYV 380 V E I I EY S G L L K E L+ Q++ + + I SG+ Y+ Sbjct: 71 ACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYL 130 Query: 381 ERMNYVHRDLRAANILVGENL---VCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 437 +HRDL+ NI++ + + K+ D G A+ ++ E +++ APE Sbjct: 131 HENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFV--GTLQYLAPELF 188 Query: 438 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC------- 490 +T D WSFG ++ E G P+ + + + C C Sbjct: 189 ENKPYTATVDYWSFGTMVFECIA-GYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEV 247 Query: 491 --------PESLHDLMCQ--------CWRKEPEER 509 P SL L+ + +P++R Sbjct: 248 RFSSHLPQPNSLCSLIVEPMENWLQLMLNWDPQQR 282 >5B2L-A nrPDB Length = 324 Score = 194 bits (494), Expect = 7e-50, Method: Composition-based stats. Identities = 68/284 (23%), Positives = 119/284 (41%), Gaps = 21/284 (7%) Query: 257 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKP---GTMSPEAFLQ 312 + ++ L ++G G G+VW + T V A+K ++ + + Sbjct: 6 TIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMD 65 Query: 313 EAQVMKKLRHEKLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA 371 V+K +VQ + ++ ++I E M G+ + LK + L M Sbjct: 66 LDVVLKSHDCPYIVQCFGTFITNTDVFIAMELM--GTSAEKLKKRMQGPIPERILGKMTV 123 Query: 372 QIASGMAYV-ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIK 430 I + Y+ E+ +HRD++ +NIL+ E K+ DFG++ + D++ R Sbjct: 124 AIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGC--AA 181 Query: 431 WTAPEAA-----LYGRFTIKSDVWSFGILLTELTTKGRVPYPGM-VNREVLDQVERGYRM 484 + APE + I++DVWS GI L EL T G+ PY + EVL +V + Sbjct: 182 YMAPERIDPPDPTKPDYDIRADVWSLGISLVELAT-GQFPYKNCKTDFEVLTKVLQEEPP 240 Query: 485 PCPPE--CPESLHDLMCQCWRKEPEERPTFEYL--QAFLEDYFT 524 P + C K+ +RP + L +F++ Y T Sbjct: 241 LLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYET 284 >2WTK-C nrPDB Length = 305 Score = 194 bits (493), Expect = 9e-50, Method: Composition-based stats. Identities = 64/269 (23%), Positives = 119/269 (44%), Gaps = 17/269 (6%) Query: 272 LEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSPE-----AFLQEAQVMKKLRHEKL 325 + LG+G +G+V + T R A+K LK + +E Q++++LRH+ + Sbjct: 9 MGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNV 68 Query: 326 VQLYAVV---SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 +QL V+ ++ +Y+V EY G + + L K + Q Q+ G+ Y+ Sbjct: 69 IQLVDVLYNEEKQKMYMVMEYCVCG-MQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHS 127 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIED-NEYTARQGAKFPIKWTAPEAA--LY 439 VH+D++ N+L+ K++ G+A + + ++ + PE A L Sbjct: 128 QGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPAFQPPEIANGLD 187 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMC 499 K D+WS G+ L +TT G P+ G ++ + + +G P +C L DL+ Sbjct: 188 TFSGFKVDIWSAGVTLYNITT-GLYPFEGDNIYKLFENIGKG-SYAIPGDCGPPLSDLLK 245 Query: 500 QCWRKEPEERPTFEYLQAFLEDYFTSTEP 528 EP +R + ++ +F P Sbjct: 246 GMLEYEPAKRFSIRQIRQ--HSWFRKKHP 272 >2QKW-B nrPDB Length = 321 Score = 194 bits (492), Expect = 1e-49, Method: Composition-based stats. Identities = 70/273 (25%), Positives = 117/273 (42%), Gaps = 20/273 (7%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKP-GTMSPEAFLQEAQVMKKLRHEKLV 326 + + +G G FG+V+ G +VA+K P + E F E + + RH LV Sbjct: 39 NNFDHKFLIGHGVFGKVYKGVLRDGAKVALKRRTPESSQGIEEFETEIETLSFCRHPHLV 98 Query: 327 QLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLR--LPQLVDMAAQIASGMAYVERM 383 L E + ++ +YM G+L L G + Q +++ A G+ Y+ Sbjct: 99 SLIGFCDERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRLEICIGAARGLHYLHTR 158 Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT-ARQGAKFPIKWTAPEAALYGRF 442 +HRD+++ NIL+ EN V K+ DFG+++ + + T K + + PE + GR Sbjct: 159 AIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVKGTLGYIDPEYFIKGRL 218 Query: 443 TIKSDVWSFGILLTELTTK-----GRVP----------YPGMVNREVLDQVERGYRMPCP 487 T KSDV+SFG++L E+ +P N ++ V+ Sbjct: 219 TEKSDVYSFGVVLFEVLCARSAIVQSLPREMVNLAEWAVESHNNGQLEQIVDPNLADKIR 278 Query: 488 PECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 PE D +C E+RP+ + LE Sbjct: 279 PESLRKFGDTAVKCLALSSEDRPSMGDVLWKLE 311 >3UIM-A nrPDB Length = 326 Score = 193 bits (490), Expect = 2e-49, Method: Composition-based stats. Identities = 74/293 (25%), Positives = 127/293 (43%), Gaps = 27/293 (9%) Query: 254 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMS--PEAFL 311 Q + + ++ ++ + LG+G FG+V+ G T VA+K LK F Sbjct: 16 QLKRFSLRELQVASDNFSNKNILGRGGFGKVYKGRLADGTLVAVKRLKEERTQGGELQFQ 75 Query: 312 QEAQVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKG--ETGKYLRLPQLVD 368 E +++ H L++L + +V YM+ GS+ L+ E+ L P+ Sbjct: 76 TEVEMISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQR 135 Query: 369 MAAQIASGMAYVERM---NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGA 425 +A A G+AY+ +HRD++AANIL+ E V DFGLA+L++ + Sbjct: 136 IALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAV 195 Query: 426 KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYP------------------ 467 + I APE G+ + K+DV+ +G++L EL T G+ + Sbjct: 196 RGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELIT-GQRAFDLARLANDDDVMLLDWVKG 254 Query: 468 GMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 + +++ V+ + E E L + C + P ERP + LE Sbjct: 255 LLKEKKLEALVDVDLQGNYKDEEVEQLIQVALLCTQSSPMERPKMSEVVRMLE 307 >5O0Y-A nrPDB Length = 579 Score = 192 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 60/285 (21%), Positives = 113/285 (39%), Gaps = 36/285 (12%) Query: 281 FGEVWMG-TWNGTTRVAIKT--LKP------GTMSPEAFLQEAQVMKKLRHEKLVQLYAV 331 F EV+ VA+K L + +E ++ K+L H ++V+LY Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDY 356 Query: 332 VS--EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN--YVH 387 S + V EY L +LK K + + + QI + + Y+ + +H Sbjct: 357 FSLDTDSFCTVLEYCEGNDLDFYLKQH--KLMSEKEARSIIMQIVNALKYLNEIKPPIIH 414 Query: 388 RDLRAANILVGEN---LVCKVADFGLARLIEDNEYTARQG------AKFPIKWTAPEAAL 438 DL+ NIL+ K+ DFGL+++++D+ Y + G + PE + Sbjct: 415 YDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFV 474 Query: 439 YG----RFTIKSDVWSFGILLTELTTKGRVPY-PGMVNREVLDQ--VERGYRMPCPPE-- 489 G + + K DVWS G++ + GR P+ +++L + + + + PP+ Sbjct: 475 VGKEPPKISNKVDVWSVGVIFYQCL-YGRKPFGHNQSQQDILQENTILKATEVQFPPKPV 533 Query: 490 CPESLHDLMCQCWRKEPEERPTFEYLQ--AFLEDYFTSTEPQYQP 532 + +C E+R + L +L + + P Sbjct: 534 VTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSP 578 >4Y83-A nrPDB Length = 332 Score = 192 bits (488), Expect = 3e-49, Method: Composition-based stats. Identities = 52/249 (20%), Positives = 104/249 (41%), Gaps = 17/249 (6%) Query: 278 QGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYA-VVSEE 335 +G FG+V++ T + +A K + P ++ RHE + +LY V+ E Sbjct: 83 RGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSD----VEIQACFRHENIAELYGAVLWGE 138 Query: 336 PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANI 395 +++ E GS+L+ K E+ +R +++ + + G+ ++ +H D++ +NI Sbjct: 139 TVHLFMEAGEGGSVLE--KLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNI 196 Query: 396 LVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILL 455 + + DFGL+ + ++ Y + + + +PE L + K+D++S G L Sbjct: 197 VFMSTKAV-LVDFGLSVQMTEDVY-FPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATL 254 Query: 456 TELTTKGRVPYPGMVNREVLDQVERGYRMPCPP------ECPESLHDLMCQCWRKEPEER 509 + T G P+ R PP +C + +L+ + P R Sbjct: 255 IHMQT-GTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHR 313 Query: 510 PTFEYLQAF 518 P L Sbjct: 314 PRAADLLKH 322 >2HW6-A nrPDB Length = 307 Score = 191 bits (486), Expect = 5e-49, Method: Composition-based stats. Identities = 47/281 (16%), Positives = 105/281 (37%), Gaps = 39/281 (13%) Query: 274 VKLGQGCFGEVWMGT-WNGTTRVAIKTL-KPGTMSPEAFLQEAQVMKKLR-HEKLVQLYA 330 LG+G + +V A+K + K S +E + + + + ++ +++L Sbjct: 19 ELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIE 78 Query: 331 VVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 ++ Y+V E + GS+L ++ + K+ + + +A+ + ++ HRD Sbjct: 79 FFEDDTRFYLVFEKLQGGSILAHIQKQ--KHFNEREASRVVRDVAAALDFLHTKGIAHRD 136 Query: 390 LRAANILVGEN---LVCKVADFGLARLIEDNEYTARQGAK------FPIKWTAPEAA--- 437 L+ NIL K+ DF L ++ N ++ APE Sbjct: 137 LKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVF 196 Query: 438 --LYGRFTIKSDVWSFGILLTELTTKGRVPYPGM---------------VNREVLDQVER 480 + + D+WS G++L + + G P+ G ++ + ++ Sbjct: 197 TDQATFYDKRCDLWSLGVVLYIMLS-GYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQE 255 Query: 481 G-YRMP--CPPECPESLHDLMCQCWRKEPEERPTFEYLQAF 518 G Y P DL+ + ++ ++R + + Sbjct: 256 GKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQH 296 >3N9X-A nrPDB Length = 432 Score = 191 bits (486), Expect = 6e-49, Method: Composition-based stats. Identities = 66/351 (18%), Positives = 119/351 (33%), Gaps = 94/351 (26%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLK---PGTMSPEAFLQEAQVMKKLRHE 323 ++ ++ +G+G +G V++ T + VAIK + + + L+E ++ +L+ + Sbjct: 26 DNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 85 Query: 324 KLVQLYAVVSEEPI------YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 +++LY ++ + + YIV E L K T +L + + + G Sbjct: 86 YIIRLYDLIIPDDLLKFDELYIVLEIAD-SDLKKLFK--TPIFLTEEHIKTILYNLLLGE 142 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT----------------- 420 ++ +HRDL+ AN L+ ++ KV DFGLAR I + T Sbjct: 143 NFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNK 202 Query: 421 ----ARQGAKFPIKWTAPE-AALYGRFTIKSDVWSFGILLTELT----------TKGRVP 465 + APE L +T D+WS G + EL T Sbjct: 203 NLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPL 262 Query: 466 YPGM-----------------VNREVLDQVERGYRMPCP--------------------- 487 +PG NR+ L+ + P Sbjct: 263 FPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIKLFPHR 322 Query: 488 ---------PECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 P + +L+ + P +R T + QA Y + Sbjct: 323 KPINLKQKYPSISDDGINLLESMLKFNPNKRITID--QALDHPYLKDVRKK 371 >5IKW-A nrPDB Length = 310 Score = 191 bits (486), Expect = 6e-49, Method: Composition-based stats. Identities = 57/278 (20%), Positives = 112/278 (40%), Gaps = 25/278 (8%) Query: 255 TQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTM-SPEAFLQE 313 + + + + R + LE L +G F V++ +G R A+K + M +E Sbjct: 1 SMSVGVRVFAVGRHQVTLEESLAEGGFSTVFLVRTHGGIRCALKRMYVNNMPDLNVCKRE 60 Query: 314 AQVMKKLR-HEKLVQLYAV----VSEE--PIYIVTEYMSKGSLLDFLKGETGKYLRLPQL 366 +MK+L H+ +V +S+ + I+ EY G +++ + + P++ Sbjct: 61 ITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEV 120 Query: 367 VDMAAQIASGMAYVERMN--YVHRDLRAANILVGENLVCKVADFGLA--RLIEDNEYTAR 422 + + +A + + +HRDL+ NIL+ + + DFG A + + + Sbjct: 121 LQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVN 180 Query: 423 QGA-----KFPIKWTAPEAAL---YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREV 474 + + APE T K+D+W+ G LL +L +P+ G + Sbjct: 181 VVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFF-TLPF-GESQVAI 238 Query: 475 LDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTF 512 D + +P ++H L+ +PE RP Sbjct: 239 CD---GNFTIPDNSRYSRNIHCLIRFMLEPDPEHRPDI 273 >4M69-B nrPDB Length = 283 Score = 190 bits (484), Expect = 8e-49, Method: Composition-based stats. Identities = 63/292 (21%), Positives = 130/292 (44%), Gaps = 26/292 (8%) Query: 254 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ- 312 Q + + K+ P L+ ++ G ++ + V IK ++ Sbjct: 1 QIKEIPKEHLGPPWTKLKTSK------MSTIYRGEYH-RSPVTIKVFNNPQAESVGIVRF 53 Query: 313 ----EAQVMKKLRHEKLVQLYAVVSEE-----PIYIVTEYMSKGSLLDFLKGETGKYLRL 363 E + MKK +++++ + ++ IV EY G+L + L E + + Sbjct: 54 TFNDEIKTMKKFDSPNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSV 113 Query: 364 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ 423 L+ + A A G+ + +HR++ +++ LV K+A F L++ TA+ Sbjct: 114 RSLLVLRA--ARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKS 171 Query: 424 G---AKFPIKWTAPEAALY--GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 + +PE + IK++++SFGI+L E+ T G++P+ G ++++ + V Sbjct: 172 TKAERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIAT-GKIPFEGCDSKKIRELV 230 Query: 479 -ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 E + P +CPE L +++ +C EP +RP+ + + L ST+ + Sbjct: 231 AEDKKQEPVGQDCPELLREIINECRAHEPSQRPSVDGILERLSAVEESTDKK 282 >5AR8-A nrPDB Length = 326 Score = 190 bits (484), Expect = 9e-49, Method: Composition-based stats. Identities = 74/302 (24%), Positives = 130/302 (43%), Gaps = 25/302 (8%) Query: 251 SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGT----M 305 + + IP L L +G G V +VA+K L T Sbjct: 15 QGMNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDS 74 Query: 306 SPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGET-GKYLRL 363 + L+EA+++ K R ++ + + +E IVTEYM GSL + L +T + Sbjct: 75 ERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAW 134 Query: 364 PQLVDMAAQIASGMAYVERMN--YVHRDLRAANILVGENLVCKVADFGLARL----IEDN 417 P + +IA G+ Y+ M +H DL+ NIL+ K+ADFGL++ + + Sbjct: 135 PLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQS 194 Query: 418 EYTARQGAKFPIKWTAPEAALYG---RFTIKSDVWSFGILLTELTTKGRVPYPGMVN-RE 473 + I + PE G R +IK D++S+ ++ E+ ++ + P+ + N + Sbjct: 195 RSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQ-PFEDVTNPLQ 253 Query: 474 VLDQVERGYRM-----PCPPECP--ESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 ++ V +G+R P + P + L+ W + P+ERP+F LE + Sbjct: 254 IMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTF 313 Query: 527 EP 528 E Sbjct: 314 EE 315 >5AP3-A nrPDB Length = 313 Score = 190 bits (484), Expect = 9e-49, Method: Composition-based stats. Identities = 57/285 (20%), Positives = 121/285 (42%), Gaps = 25/285 (8%) Query: 254 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAF--- 310 T+ L + + + ++G G +V+ AIK + + Sbjct: 14 GTENLYFQSMSVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSY 73 Query: 311 LQEAQVMKKLR--HEKLVQLYAV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLV 367 E + KL+ +K+++LY ++++ IY+V E L +LK + K + + Sbjct: 74 RNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME-CGNIDLNGWLKKK--KSIDPWERK 130 Query: 368 DMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAK 426 + + + + VH DL+ AN L+ + + K+ DFG+A ++ D + Sbjct: 131 SYWKNMLEAVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQV 189 Query: 427 FPIKWTAPEAALYGRFTIK-----------SDVWSFGILLTELTTKGRVPYPGMVNR--E 473 + + PEA + + SDVWS G +L + T G+ P+ ++N+ + Sbjct: 190 GTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYM-TYGKTPFQQIINQISK 248 Query: 474 VLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAF 518 + ++ + + P + L D++ C +++P++R + L A Sbjct: 249 LHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAH 293 >4RT7-A nrPDB Length = 415 Score = 190 bits (483), Expect = 1e-48, Method: Composition-based stats. Identities = 78/215 (36%), Positives = 116/215 (53%), Gaps = 19/215 (8%) Query: 312 QEAQVMKKLRHEK---LVQLYA--VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQL 366 +E Q+ H + L+ SE+ I EY ++ L + E L L Sbjct: 198 REVQI-----HPDSDQISGLHGNSFHSEDEI----EYENQKRLEE---EEDLNVLTFEDL 245 Query: 367 VDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR-LIEDNEYTARQGA 425 + A Q+A GM ++E + VHRDL A N+LV V K+ DFGLAR ++ D+ Y R A Sbjct: 246 LCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNA 305 Query: 426 KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMV-NREVLDQVERGYRM 484 + P+KW APE+ G +TIKSDVWS+GILL E+ + G PYPG+ + ++ G++M Sbjct: 306 RLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKM 365 Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFL 519 P E ++ +M CW + +RP+F L +FL Sbjct: 366 DQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 400 Score = 107 bits (267), Expect = 1e-23, Method: Composition-based stats. Identities = 38/120 (31%), Positives = 58/120 (48%), Gaps = 10/120 (8%) Query: 251 SKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNG------TTRVAIKTLKP-- 302 + WE PRE+L LG G FG+V T G + +VA+K LK Sbjct: 48 YVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKA 107 Query: 303 GTMSPEAFLQEAQVMKKL-RHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKY 360 + EA + E ++M +L HE +V L + PIY++ EY G LL++L+ + K+ Sbjct: 108 DSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKF 167 >3RP9-A nrPDB Length = 458 Score = 189 bits (480), Expect = 3e-48, Method: Composition-based stats. Identities = 74/398 (18%), Positives = 123/398 (30%), Gaps = 113/398 (28%) Query: 234 SKHADGLCHRLTTVCPTSKPQTQGLAKDA----------WEIPRESLRLEVKLGQGCFGE 283 +H G H ++ + + Q + W+IP + + +G G +G Sbjct: 10 QQHNSGTQHTVSGSQQEGQQRKQHHSSKPTASMPRPHSDWQIP-DRYEIRHLIGTGSYGH 68 Query: 284 VWMGTWNGTTRV-AIKTLK---PGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE----- 334 V RV AIK + + + L+E ++ +L H+ +V++ +V Sbjct: 69 VCEAYDKLEKRVVAIKKILRVFEDLIDCKRILREIAILNRLNHDHVVKVLDIVIPKDVEK 128 Query: 335 -EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAA 393 + +Y+V E S L T YL + + + G+ YV +HRDL+ A Sbjct: 129 FDELYVVLEIAD--SDFKKLF-RTPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPA 185 Query: 394 NILVGENLVCKVADFGLARLIE--------------------------DNEYTARQGAKF 427 N LV ++ KV DFGLAR ++ N G Sbjct: 186 NCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLKRQLTGHVV 245 Query: 428 PIKWTAPE-AALYGRFTIKSDVWSFGILLTELTTKGR----------VPYPGMV------ 470 + APE L +T DVWS G + EL + +PG Sbjct: 246 TRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKENVAYHADRGPLFPGSSCFPLSP 305 Query: 471 --------------NREVLDQVERGYRMPCPPEC-------------------------- 490 NR+ L+ + P + Sbjct: 306 DQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEKEDAKRYIRIFPKREGTDLAER 365 Query: 491 ----PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFT 524 L+ + P +R T +F Sbjct: 366 FPASSADAIHLLKRMLVFNPNKRITINE--CLAHPFFK 401 >5KKR-C nrPDB Length = 395 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 64/310 (20%), Positives = 115/310 (37%), Gaps = 54/310 (17%) Query: 257 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSP---EAFLQE 313 + E+ + +LG G G V+ + + V + L + P ++E Sbjct: 57 TQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRE 116 Query: 314 AQVMKKLRHEKLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQ 372 QV+ + +V Y S+ I I E+M GSL LK + L ++ Sbjct: 117 LQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKK--AGRIPEQILGKVSIA 174 Query: 373 IASGMAYV-ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKW 431 + G+ Y+ E+ +HRD++ +NILV K+ DFG++ + D+ + G + + Sbjct: 175 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS---Y 231 Query: 432 TAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNRE------------------ 473 +PE ++++SD+WS G+ L E+ GR P P +E Sbjct: 232 MSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPP 290 Query: 474 ---------------------VLDQVERGYRMPCPPE----CPESLHDLMCQCWRKEPEE 508 + + ++ P P D + +C K P E Sbjct: 291 RPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSLEFQDFVNKCLIKNPAE 350 Query: 509 RPTFEYLQAF 518 R + L Sbjct: 351 RADLKQLMVH 360 >6GVJ-A nrPDB Length = 429 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 56/269 (20%), Positives = 117/269 (43%), Gaps = 25/269 (9%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAF---LQEAQVMKKLR-H-EK 324 + ++G G +V+ AIK + + E + KL+ H +K Sbjct: 146 YSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDK 205 Query: 325 LVQLYAV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 +++LY ++++ IY+V E L +LK + K + + + + + + Sbjct: 206 IIRLYDYEITDQYIYMVME-CGNIDLNSWLKKK--KSIDPWERKSYWKNMLEAVHTIHQH 262 Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRF 442 VH DL+ AN L+ + + K+ DFG+A ++ D + + + PEA Sbjct: 263 GIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 321 Query: 443 TIK-----------SDVWSFGILLTELTTKGRVPYPGMVNR--EVLDQVERGYRMPCPPE 489 + + SDVWS G +L + T G+ P+ ++N+ ++ ++ + + P Sbjct: 322 SRENGKSKSKISPKSDVWSLGCILYYM-TYGKTPFQQIINQISKLHAIIDPNHEIEFPDI 380 Query: 490 CPESLHDLMCQCWRKEPEERPTFEYLQAF 518 + L D++ C +++P++R + L A Sbjct: 381 PEKDLQDVLKCCLKRDPKQRISIPELLAH 409 >1TKI-A nrPDB Length = 321 Score = 189 bits (479), Expect = 4e-48, Method: Composition-based stats. Identities = 49/260 (18%), Positives = 103/260 (39%), Gaps = 13/260 (5%) Query: 272 LEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYA 330 + LG+G FG V + + K +K +E ++ RH ++ L+ Sbjct: 9 IAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVKGTDQVLVKKEISILNIARHRNILHLHE 68 Query: 331 VVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRD 389 E + ++ E++S + + + + L ++V Q+ + ++ N H D Sbjct: 69 SFESMEELVMIFEFISGLDIFERINTSAFE-LNEREIVSYVHQVCEALQFLHSHNIGHFD 127 Query: 390 LRAANILVG--ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSD 447 +R NI+ + K+ +FG AR ++ + ++ APE + + +D Sbjct: 128 IRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFT--APEYYAPEVHQHDVVSTATD 185 Query: 448 VWSFGILLTELTTKGRVPYPGMVNREVLDQV---ERGYRMPCPPECPESLHDLMCQCWRK 504 +WS G L+ L + G P+ N+++++ + E + E D + + K Sbjct: 186 MWSLGTLVYVLLS-GINPFLAETNQQIIENIMNAEYTFDEEAFKEISIEAMDFVDRLLVK 244 Query: 505 EPEERPTFEYLQAFLEDYFT 524 E + R T A + Sbjct: 245 ERKSRMTASE--ALQHPWLK 262 >3EQC-A nrPDB Length = 360 Score = 188 bits (478), Expect = 4e-48, Method: Composition-based stats. Identities = 64/310 (20%), Positives = 115/310 (37%), Gaps = 54/310 (17%) Query: 257 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSP---EAFLQE 313 + E+ + +LG G G V+ + + V + L + P ++E Sbjct: 22 TQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRE 81 Query: 314 AQVMKKLRHEKLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQ 372 QV+ + +V Y S+ I I E+M GSL LK + L ++ Sbjct: 82 LQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKK--AGRIPEQILGKVSIA 139 Query: 373 IASGMAYV-ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKW 431 + G+ Y+ E+ +HRD++ +NILV K+ DFG++ + D+ + G + + Sbjct: 140 VIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS---Y 196 Query: 432 TAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNRE------------------ 473 +PE ++++SD+WS G+ L E+ GR P P +E Sbjct: 197 MSPERLQGTHYSVQSDIWSMGLSLVEMAV-GRYPIPPPDAKELELMFGCQVEGDAAETPP 255 Query: 474 ---------------------VLDQVERGYRMPCPPE----CPESLHDLMCQCWRKEPEE 508 + + ++ P P D + +C K P E Sbjct: 256 RPRTPGRPLNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAE 315 Query: 509 RPTFEYLQAF 518 R + L Sbjct: 316 RADLKQLMVH 325 >4X7Q-B nrPDB Length = 312 Score = 188 bits (478), Expect = 5e-48, Method: Composition-based stats. Identities = 62/272 (22%), Positives = 112/272 (41%), Gaps = 31/272 (11%) Query: 267 RESLRLEVKLGQGCFGEVWMG-TWNGTTRVAIKTLKPGTMSPEAFLQ-------EAQVMK 318 RL LG+G FG V+ G +VAIK + + + L E ++ Sbjct: 30 EAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLW 89 Query: 319 KLR----HEKLVQLYAVV-SEEPIYIVTEY-MSKGSLLDFLKGETGKYLRLPQLVDMAAQ 372 K+ H +++L ++E +V E + L D++ + L Q Sbjct: 90 KVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKG--PLGEGPSRCFFGQ 147 Query: 373 IASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLIEDNEYTARQGAKFPIKW 431 + + + + VHRD++ NIL+ K+ DFG L+ D YT G + + Sbjct: 148 VVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRV---Y 204 Query: 432 TAPEAALYGRFTI-KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPEC 490 + PE ++ + VWS GILL ++ G +P+ ++E+L+ + P Sbjct: 205 SPPEWISRHQYHALPATVWSLGILLYDMVC-GDIPF--ERDQEILEA-----ELHFPAHV 256 Query: 491 PESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 L+ +C +P RP+ E + L+ + Sbjct: 257 SPDCCALIRRCLAPKPSSRPSLEEI--LLDPW 286 >6HV0-A nrPDB Length = 416 Score = 188 bits (477), Expect = 6e-48, Method: Composition-based stats. Identities = 64/273 (23%), Positives = 123/273 (45%), Gaps = 24/273 (8%) Query: 275 KLGQGCFGE-VWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR-HEKLVQLYAVV 332 LG G G V+ G VA+K + P S +E Q++++ H +++ + Sbjct: 15 VLGHGAEGTIVYRG-MFDNRDVAVKRILPECFSFAD--REVQLLRESDEHPNVIRYFCTE 71 Query: 333 SEEPI-YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLR 391 + YI E + +L ++++ + +L L + + + Q SG+A++ +N VHRDL+ Sbjct: 72 KDRQFQYIAIELCAA-TLQEYVEQKDFAHLGL-EPITLLQQTTSGLAHLHSLNIVHRDLK 129 Query: 392 AANILV---GENLVCK--VADFGLARLIE--DNEYTARQGAKFPIKWTAPEAAL---YGR 441 NIL+ + K ++DFGL + + + ++ R G W APE Sbjct: 130 PHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKEN 189 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPC-PPECPESL--HDLM 498 T D++S G + + ++G P+ G + + + + C PE E + +L+ Sbjct: 190 PTYTVDIFSAGCVFYYVISEGSHPF-GKSLQRQANILLGACSLDCLHPEKHEDVIARELI 248 Query: 499 CQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQ 531 + +P++RP+ + +F S E Q Q Sbjct: 249 EKMIAMDPQKRPSAK--HVLKHPFFWSLEKQLQ 279 >6FYV-A nrPDB Length = 337 Score = 188 bits (477), Expect = 6e-48, Method: Composition-based stats. Identities = 73/334 (21%), Positives = 115/334 (34%), Gaps = 79/334 (23%) Query: 261 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNG--TTRVAIKTLKPGTMSPEAFLQEAQVMK 318 + ++ R + LG+G FG+V +G VA+K +K EA E QV++ Sbjct: 7 QSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLE 66 Query: 319 KLRH--EK----LVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA 371 L VQ+ + IV E + S DF+K + ++ + MA Sbjct: 67 HLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELL-GLSTYDFIKENSFLPFQIDHIRQMAY 125 Query: 372 QIASGMAYVERMNYVHRDLRAANILVG-------------------ENLVCKVADFGLAR 412 QI + ++ H DL+ NIL +N KV DFG A Sbjct: 126 QICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSAT 185 Query: 413 LIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR 472 +D ++ + + APE L ++ DVWS G +L E G + ++ Sbjct: 186 -YDDEHHSTLVSTR---HYRAPEVILALGWSQPCDVWSIGCILIE-YYLGFTVFQTHDSK 240 Query: 473 EVLDQVERGY-------------------------------------------RMPCPPE 489 E L +ER M C E Sbjct: 241 EHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDE 300 Query: 490 CPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 E L DL+ + +P +R T + A +F Sbjct: 301 EHEKLFDLVRRMLEYDPTQRITLDE--ALQHPFF 332 >5X8I-B nrPDB Length = 346 Score = 187 bits (476), Expect = 8e-48, Method: Composition-based stats. Identities = 75/339 (22%), Positives = 113/339 (33%), Gaps = 79/339 (23%) Query: 256 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWN--GTTRVAIKTLKPGTMSPEAFLQE 313 L + ++ + LG+G FG+V + G VA+K +K EA E Sbjct: 1 MHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSE 60 Query: 314 AQVMKKLR--HEK----LVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQL 366 QV++ L VQ+ I IV E + S DF+K RL + Sbjct: 61 IQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELL-GLSTYDFIKENGFLPFRLDHI 119 Query: 367 VDMAAQIASGMAYVERMNYVHRDLRAANILVGE-------------------NLVCKVAD 407 MA QI + ++ H DL+ NIL + N KV D Sbjct: 120 RKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVD 179 Query: 408 FGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYP 467 FG A +D ++ + + APE L ++ DVWS G +L E G +P Sbjct: 180 FGSAT-YDDEHHSTLVSTR---HYRAPEVILALGWSQPCDVWSIGCILIE-YYLGFTVFP 234 Query: 468 GMVNREVLDQVERGY--------------------RMPCPPECP---------------- 491 ++E L +ER R+ Sbjct: 235 THDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFM 294 Query: 492 -------ESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 E L DL+ + +P +R T A +F Sbjct: 295 LSQDVEHERLFDLIQKMLEYDPAKRITLRE--ALKHPFF 331 >3PG1-A nrPDB Length = 362 Score = 187 bits (476), Expect = 8e-48, Method: Composition-based stats. Identities = 60/330 (18%), Positives = 105/330 (31%), Gaps = 57/330 (17%) Query: 248 CPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKT-------- 299 + ++ + G +G V G + VAIK Sbjct: 2 MQAKGEAAMRDLIAELHAMQSPYTVQRFISSGSYGAVCAGVDSEGIPVAIKRVFNTVSDG 61 Query: 300 ----LKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE------EPIYIVTEYMSKGSL 349 + + + L+E +++ H ++ L + +Y+VTE M L Sbjct: 62 RTVNILSDSFLCKRVLREIRLLNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRT-DL 120 Query: 350 LDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFG 409 + + + + I G+ + VHRDL NIL+ +N + DF Sbjct: 121 AQVIH-DQRIVISPQHIQYFMYHILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFN 179 Query: 410 LARLIEDNEYTARQGAKFPIKWTAPEAALY-GRFTIKSDVWSFGILLTELTTKGRVPYPG 468 LAR ED + + APE + FT D+WS G ++ E+ + + + G Sbjct: 180 LAR--EDTADANKTHYVTHRWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKAL-FRG 236 Query: 469 MVNREVLDQVERGYRMPCPPEC----PESLH---------------------------DL 497 L+++ P + S DL Sbjct: 237 STFYNQLNKIVEVVGTPKIEDVVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDL 296 Query: 498 MCQCWRKEPEERPTFEYLQAFLEDYFTSTE 527 + + P+ R + E QA YF S Sbjct: 297 IAKMLEFNPQRRISTE--QALRHPYFESLF 324 >4PL5-B nrPDB Length = 435 Score = 187 bits (476), Expect = 8e-48, Method: Composition-based stats. Identities = 61/273 (22%), Positives = 119/273 (43%), Gaps = 24/273 (8%) Query: 275 KLGQGCFGE-VWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR-HEKLVQLYAVV 332 LG G G V+ G VA+K + P S +E Q++++ H +++ + Sbjct: 34 VLGHGAEGTIVYKG-MFDNRDVAVKRILPECFSFAD--REVQLLRESDEHPNVIRYFCTE 90 Query: 333 SEEPI-YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLR 391 + YI E + +L ++++ + +L L + + + Q SG+A++ +N VHRDL+ Sbjct: 91 KDRQFQYIAIELCAA-TLQEYVEQKDFAHLGL-EPITLLHQTTSGLAHLHSLNIVHRDLK 148 Query: 392 AANILV---GENLVCK--VADFGLARLIE--DNEYTARQGAKFPIKWTAPEAAL---YGR 441 NIL+ + K ++DFGL + + + ++ R G W APE Sbjct: 149 PHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKDN 208 Query: 442 FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPES---LHDLM 498 T D++S G + + ++G P+ G + + + + C +L+ Sbjct: 209 PTYTVDIFSAGCVFYYVISEGYHPF-GKSLQRQANILLGACNLDCFHSDKHEDVIARELI 267 Query: 499 CQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQ 531 + +P++RP+ + +F S E Q Q Sbjct: 268 EKMIAMDPQQRPSAK--HVLKHPFFWSLEKQLQ 298 >3DLS-A nrPDB Length = 335 Score = 187 bits (476), Expect = 8e-48, Method: Composition-based stats. Identities = 54/255 (21%), Positives = 105/255 (41%), Gaps = 25/255 (9%) Query: 275 KLGQGCFGEVWMGTWN-GTTRVAIKTLKPGTMSPEAFLQ---------EAQVMKKLRHEK 324 LG G FG VW V +K +K + + +++ E ++ ++ H Sbjct: 31 PLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILSRVEHAN 90 Query: 325 LVQLYAVVSEEPIY-IVTEYMSKG-SLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 ++++ + + + +V E G L F+ + L P + Q+ S + Y+ Sbjct: 91 IIKVLDIFENQGFFQLVMEKHGSGLDLFAFI--DRHPRLDEPLASYIFRQLVSAVGYLRL 148 Query: 383 MNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF 442 + +HRD++ NI++ E+ K+ DFG A +E + I++ APE + + Sbjct: 149 KDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGK--LFYTFCGTIEYCAPEVLMGNPY 206 Query: 443 -TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQC 501 + ++WS G+ L L + P+ E ++ + P + L L+ Sbjct: 207 RGPELEMWSLGVTLYTLVFE-ENPF--CELEETVEAA-----IHPPYLVSKELMSLVSGL 258 Query: 502 WRKEPEERPTFEYLQ 516 + PE R T E L Sbjct: 259 LQPVPERRTTLEKLV 273 >3HAJ-A nrPDB Length = 486 Score = 187 bits (475), Expect = 1e-47, Method: Composition-based stats. Identities = 36/138 (26%), Positives = 60/138 (43%), Gaps = 5/138 (3%) Query: 6 SKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFG 65 S P ++Q + S P E+ G T +K S+ + ++ ++ + Sbjct: 349 SNPAQSAQSQSSYNPFEDEDDTGSTVSEKDDTKAKNVSS---YEKTQSYPTDWSDDESNN 405 Query: 66 GFNSSDTV--TSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWL 123 F+S+D ++P +G ALYDYE + +LSFK G+ L + + + W Sbjct: 406 PFSSTDANGDSNPFDDDATSGTEVRVRALYDYEGQEHDELSFKAGDELTKMEDEDEQGWC 465 Query: 124 AHSLSTGQTGYIPSNYVA 141 L GQ G P+NYV Sbjct: 466 KGRLDNGQVGLYPANYVE 483 >4X3F-A nrPDB Length = 337 Score = 187 bits (475), Expect = 1e-47, Method: Composition-based stats. Identities = 68/264 (25%), Positives = 107/264 (40%), Gaps = 14/264 (5%) Query: 257 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSP----EAFL 311 G++ RL+ + G G+VW N RVA+K LK S E F Sbjct: 1 GMSPRVGVTLSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFR 60 Query: 312 QEAQVMKKLRHEKLVQLYAVVSEE------PIYIVTEYMSKGSLLDFLKGETGKYLRLPQ 365 EA+ L H + ++ + Y+V E ++ L LK L L Sbjct: 61 AEARTTAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRH 118 Query: 366 LVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGA 425 +DM Q + VHRD++ NIL+ K+ DFG+A+ ++ T Sbjct: 119 ALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMV 178 Query: 426 KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP 485 ++ APE AL + SDV+S G++ E G+ P+ G V + + P Sbjct: 179 MGTAQYIAPEQALGHDASPASDVYSLGVVGYE-AVSGKRPFAGDGALTVAMKHIKEPPPP 237 Query: 486 CPPECPESLHDLMCQCWRKEPEER 509 PP+ P ++ +L+ K P R Sbjct: 238 LPPDLPPNVRELIEITLVKNPAMR 261 >4OW8-A nrPDB Length = 283 Score = 187 bits (474), Expect = 2e-47, Method: Composition-based stats. Identities = 67/253 (26%), Positives = 104/253 (41%), Gaps = 14/253 (5%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSP----EAFLQEAQVMKKLRH 322 RL+ + G G+VW N RVA+K LK S E F EA+ L H Sbjct: 11 GRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNH 70 Query: 323 EKLVQLYAVVSEE------PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 + ++ + Y+V E ++ L LK L L +DM Q Sbjct: 71 PGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTGRA 128 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 + VHRD++ NIL+ K+ DFG+A+ ++ T ++ APE Sbjct: 129 LQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQ 188 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 AL + SDV+S G++ E G+ P+ G V + + P PP+ P ++ + Sbjct: 189 ALGHDASPASDVYSLGVVGYE-AVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRE 247 Query: 497 LMCQCWRKEPEER 509 L+ K P R Sbjct: 248 LIEITLVKNPAMR 260 >5AIR-A nrPDB Length = 430 Score = 186 bits (473), Expect = 2e-47, Method: Composition-based stats. Identities = 59/282 (20%), Positives = 99/282 (35%), Gaps = 45/282 (15%) Query: 269 SLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQ 327 S +G G FG V+ + VAIK + +E Q+M+KL H +V+ Sbjct: 65 SYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---RELQIMRKLDHCNIVR 121 Query: 328 LYAVV-----SEEPIYI--VTEYMSKGSLL-DFLKGETGKYLRLPQLVDMAAQIASGMAY 379 L ++ +Y+ V +Y+ + + L + + Q+ +AY Sbjct: 122 LRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAY 181 Query: 380 VERMNYVHRDLRAANILVGENLVC-KVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438 + HRD++ N+L+ + K+ DFG A+ + E + APE Sbjct: 182 IHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYIC--SRYYRAPELIF 239 Query: 439 Y-GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP------------ 485 +T DVWS G +L EL G+ +PG + L ++ + P Sbjct: 240 GATDYTSSIDVWSAGCVLAELL-LGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNY 298 Query: 486 ----------------CPPECPESLHDLMCQCWRKEPEERPT 511 P P L + P R T Sbjct: 299 TEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT 340 >6B2Q-A nrPDB Length = 317 Score = 186 bits (473), Expect = 2e-47, Method: Composition-based stats. Identities = 67/253 (26%), Positives = 104/253 (41%), Gaps = 14/253 (5%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSP----EAFLQEAQVMKKLRH 322 RL+ + G G+VW N RVA+K LK S E F EA+ L H Sbjct: 32 GRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFIERFRAEARTTAMLNH 91 Query: 323 EKLVQLYAVVSEE------PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 + ++ + Y+V E ++ L LK L L +DM Q Sbjct: 92 PGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDMLEQTGRA 149 Query: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 + VHRD++ NIL+ K+ DFG+A+ ++ T ++ APE Sbjct: 150 LQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQ 209 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 AL + SDV+S G++ E G+ P+ G V + + P PP+ P ++ + Sbjct: 210 ALGHDASPASDVYSLGVVGYE-AVSGKRPFAGDGALTVAMKHIKEPPPPLPPDLPPNVRE 268 Query: 497 LMCQCWRKEPEER 509 L+ K P R Sbjct: 269 LIEITLVKNPAMR 281 >3HMP-A nrPDB Length = 342 Score = 186 bits (473), Expect = 2e-47, Method: Composition-based stats. Identities = 55/269 (20%), Positives = 116/269 (43%), Gaps = 25/269 (9%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAF---LQEAQVMKKLR--HEK 324 + ++G G +V+ AIK + + E + KL+ +K Sbjct: 58 YSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDK 117 Query: 325 LVQLYAV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 +++LY ++++ IY+V E L +LK + K + + + + + + Sbjct: 118 IIRLYDYEITDQYIYMVME-CGNIDLNSWLKKK--KSIDPWERKSYWKNMLEAVHTIHQH 174 Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRF 442 VH DL+ AN L+ + + K+ DFG+A ++ D + + + PEA Sbjct: 175 GIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSS 233 Query: 443 TIK-----------SDVWSFGILLTELTTKGRVPYPGMVNR--EVLDQVERGYRMPCPPE 489 + + SDVWS G +L + T G+ P+ ++N+ ++ ++ + + P Sbjct: 234 SRENGKSKSKISPKSDVWSLGCILYYM-TYGKTPFQQIINQISKLHAIIDPNHEIEFPDI 292 Query: 490 CPESLHDLMCQCWRKEPEERPTFEYLQAF 518 + L D++ C +++P++R + L A Sbjct: 293 PEKDLQDVLKCCLKRDPKQRISIPELLAH 321 >4C59-A nrPDB Length = 340 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 69/297 (23%), Positives = 111/297 (37%), Gaps = 34/297 (11%) Query: 255 TQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP-EAFLQ 312 E+ LR+ L +G F V+ G+ R A+K L A +Q Sbjct: 14 QSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQ 73 Query: 313 EAQVMKKLR-HEKLVQLYAVVS---------EEPIYIVTEYMSKGSLLDFLKG-ETGKYL 361 E MKKL H +VQ + S + ++TE KG L++FLK E+ L Sbjct: 74 EVCFMKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELC-KGQLVEFLKKMESRGPL 132 Query: 362 RLPQLVDMAAQIASGMAYVERMN--YVHRDLRAANILVGENLVCKVADFGLARLIEDNEY 419 ++ + Q + ++ R +HRDL+ N+L+ K+ DFG A I Sbjct: 133 SCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPD 192 Query: 420 TARQGAK-----------FPIKWTAPEAA-LYGRF--TIKSDVWSFGILLTELTTKGRVP 465 + + + PE LY F K D+W+ G +L L + P Sbjct: 193 YSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILY-LLCFRQHP 251 Query: 466 YPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 + + V Y +P H L+ + PEER + + L++ Sbjct: 252 FEDGAKLRI---VNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQLQEI 305 >3NIE-A nrPDB Length = 429 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 62/354 (17%), Positives = 117/354 (33%), Gaps = 97/354 (27%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLK---PGTMSPEAFLQEAQVMKKLRHE 323 ++ ++ +G+G +G V++ + VAIK + + + L+E ++ +L+ + Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRMFEDLIDCKRILREITILNRLKSD 87 Query: 324 KLVQLYAVVSEEPI------YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 +++L+ ++ E + YIV E L K T +L + + + G Sbjct: 88 YIIRLHDLIIPEDLLKFDELYIVLEIAD-SDLKKLFK--TPIFLTEQHVKTILYNLLLGE 144 Query: 378 AYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEY------------------ 419 ++ +HRDL+ AN L+ ++ K+ DFGLAR I ++ Sbjct: 145 KFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENEEPGP 204 Query: 420 ------TARQGAKFPIKWTAPE-AALYGRFTIKSDVWSFGILLTELT----------TKG 462 + APE L +T D+WS G + EL T Sbjct: 205 HNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINNPTNR 264 Query: 463 RVPYPG-----------------MVNREVLDQVERGYRMPCPPE---------------- 489 +PG NR+ L+ + P + Sbjct: 265 FPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKYIKLF 324 Query: 490 --------------CPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 + DL+ R ++R T + A Y + Sbjct: 325 PTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDK--ALSHPYLKDVRKE 376 >5TE0-A nrPDB Length = 347 Score = 185 bits (471), Expect = 3e-47, Method: Composition-based stats. Identities = 52/281 (18%), Positives = 108/281 (38%), Gaps = 26/281 (9%) Query: 256 QGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL-KPGTMSPEAFLQEA 314 G + I R+ + ++ L +G F V++ + + A+K + + +E Sbjct: 7 SGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREI 66 Query: 315 QVMKKLR-HEKLVQLYAVVSEE-------PIYIVTEYMSKGSLLDFLKGETGKYLRLPQL 366 Q+M+ L H+ +V + I+ ++ G +++ + ++ Sbjct: 67 QIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEV 126 Query: 367 VDMAAQIASGMAYVERMN--YVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG 424 + + +A + + +HRDL+ NIL+ + + DFG A N T Sbjct: 127 LQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVN 186 Query: 425 A-------KFPIKWTAPEAAL---YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREV 474 A + + APE T K+D+W+ G LL +L +P+ G + Sbjct: 187 AVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYF-TLPF-GESQVAI 244 Query: 475 LDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYL 515 D + +P + +H L+ +P++RP + Sbjct: 245 CD---GNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQV 282 >4LQP-A nrPDB Length = 508 Score = 185 bits (470), Expect = 4e-47, Method: Composition-based stats. Identities = 56/327 (17%), Positives = 107/327 (32%), Gaps = 73/327 (22%) Query: 252 KPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEA- 309 K ++Q L + E +G+G FGEV + T ++ A+KTL M + Sbjct: 86 KKESQFLRLRRTRLSLEDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQ 145 Query: 310 ---FLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQ 365 E V+ +V LY + + +Y++ E++ G L+ L + Sbjct: 146 LAHVKAERDVLAGSDSPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRW--QLFTEDV 203 Query: 366 LVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADF----------------- 408 A+ + + ++ ++HR ++ NIL+ K++DF Sbjct: 204 TRFYMAECILAIETIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKK 263 Query: 409 ---------GLARLIEDNEYTARQ----------------------------------GA 425 G+++ N T Sbjct: 264 LLQQDEATNGISKPGTYNANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYST 323 Query: 426 KFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV---ERGY 482 + APE LY + + D WS G ++ E G P+ +E ++ E+ Sbjct: 324 VGTPDYIAPEIFLYQGYGQECDWWSLGAIMYECL-IGWPPFCSETPQETYRKIMNFEQTL 382 Query: 483 RMPCPPECPESLHDLMCQCWRKEPEER 509 + P DL+ + ++R Sbjct: 383 QFPDDIHISYEAEDLIRRLLTH-ADQR 408 >2I6L-A nrPDB Length = 320 Score = 185 bits (470), Expect = 4e-47, Method: Composition-based stats. Identities = 65/292 (22%), Positives = 110/292 (37%), Gaps = 55/292 (18%) Query: 273 EVKLGQGCFGEVWMGTWNG-TTRVAIKTL-KPGTMSPEAFLQEAQVMKKLRHEKLVQLYA 330 LG G G V+ N RVAIK + S + L+E +++++L H+ +V+++ Sbjct: 16 LKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFE 75 Query: 331 VVSE---------------EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIAS 375 ++ +YIV EYM L + L+ L Q+ Sbjct: 76 ILGPSGSQLTDDVGSLTELNSVYIVQEYMET-DLANVLEQ---GPLLEEHARLFMYQLLR 131 Query: 376 GMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLIEDN--EYTARQGAKFPIKWT 432 G+ Y+ N +HRDL+ AN+ + E+LV K+ DFGLAR+++ + + Sbjct: 132 GLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYR 191 Query: 433 APEAALY-GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY--------- 482 +P L +T D+W+ G + E+ T G+ + G E + + Sbjct: 192 SPRLLLSPNNYTKAIDMWAAGCIFAEMLT-GKTLFAGAHELEQMQLILESIPVVHEEDRQ 250 Query: 483 ---------------RMPCP-----PECPESLHDLMCQCWRKEPEERPTFEY 514 P P D + Q P +R T E Sbjct: 251 ELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLTAEE 302 >3QA8-A nrPDB Length = 676 Score = 185 bits (469), Expect = 6e-47, Method: Composition-based stats. Identities = 58/225 (25%), Positives = 97/225 (43%), Gaps = 16/225 (7%) Query: 271 RLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKP--GTMSPEAFLQEAQVMKKLRHEKLVQ 327 ++ +LG G FG V T +VAIK + + E + E Q+MKKL H +V Sbjct: 17 EMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCLEIQIMKKLNHPNVVS 76 Query: 328 LYAV------VSEEPI-YIVTEYMSKGSLLDFLKG-ETGKYLRLPQLVDMAAQIASGMAY 379 V ++ + + EY G L +L E L+ + + + I+S + Y Sbjct: 77 AREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALRY 136 Query: 380 VERMNYVHRDLRAANILVG---ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 + +HRDL+ NI++ + L+ K+ D G A+ ++ E +++ APE Sbjct: 137 LHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFV--GTLQYLAPEL 194 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481 ++T+ D WSFG L E T R P + +V Sbjct: 195 LEQKKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVREK 239 >6BFN-A nrPDB Length = 342 Score = 184 bits (468), Expect = 6e-47, Method: Composition-based stats. Identities = 71/313 (22%), Positives = 122/313 (38%), Gaps = 59/313 (18%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPG-----TMSPEAFLQEAQVMKKLRH 322 + E+K+G+G FG V+ T A+K LK T ++FL E + + + RH Sbjct: 22 HNFSEELKIGEGGFGCVYRAVMRNTV-YAVKRLKENADLEWTAVKQSFLTEVEQLSRFRH 80 Query: 323 EKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETG--KYLRLPQLVDMAAQIASGMAY 379 +V ++ Y +V ++ GSL D L +T L PQ +D+ A + + Sbjct: 81 PNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQF 140 Query: 380 VE--RMNYVHRDLRAANILVGENLVCKVADFGLARL--------IEDNEYTARQGAKFPI 429 + + +H D++++N+L+ E L K+ DFGLAR + + Q + + Sbjct: 141 LHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTL 200 Query: 430 KWTAPEAALYGRFTIKSDVWSFGILLTELTTKGR-VPYPGMVNREVLD------------ 476 + E GR + +D +SFG+++ E R V G + + D Sbjct: 201 AYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKYLKDLVEEEAEEAGVA 260 Query: 477 -----------------------QVERGYRMPCPPECPES----LHDLMCQCWRKEPEER 509 Q+ + + P P CP L L C C + + R Sbjct: 261 LRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGLGQLACCCLHRRAKRR 320 Query: 510 PTFEYLQAFLEDY 522 P + LE Sbjct: 321 PPMTQVYERLEKL 333 >4KIK-B nrPDB Length = 677 Score = 184 bits (468), Expect = 6e-47, Method: Composition-based stats. Identities = 63/281 (22%), Positives = 110/281 (39%), Gaps = 41/281 (14%) Query: 271 RLEVKLGQGCFGEVWMGTWNGTT-RVAIKTLKP--GTMSPEAFLQEAQVMKKLRHEKLVQ 327 ++ +LG G FG V T ++AIK + + E + E Q+M++L H +V Sbjct: 22 EMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVA 81 Query: 328 LYAVVS-------EEPIYIVTEYMSKGSLLDFLKG-ETGKYLRLPQLVDMAAQIASGMAY 379 V + + EY G L +L E LR ++ + + IAS + Y Sbjct: 82 ARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLSDIASALRY 141 Query: 380 VERMNYVHRDLRAANILVGEN---LVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 + +HRDL+ NI++ + L+ K+ D G A+ ++ + +++ APE Sbjct: 142 LHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQG--SLCTSFVGTLQYLAPEL 199 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR------------- 483 ++T+ D WSFG L E T R P + +V + Sbjct: 200 LEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTV 259 Query: 484 -----MPCPPECPESLHDLMCQ----CWRKEPEER---PTF 512 +P P L + + + P +R PT+ Sbjct: 260 KFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTY 300 >3MDY-A nrPDB Length = 337 Score = 184 bits (467), Expect = 8e-47, Method: Composition-based stats. Identities = 77/304 (25%), Positives = 134/304 (44%), Gaps = 50/304 (16%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKK--LRHEKL 325 + +++ ++G+G +GEVWMG W G +VA+K T ++ +E ++ + +RHE + Sbjct: 37 KQIQMVKQIGKGRYGEVWMGKWRG-EKVAVKVF--FTTEEASWFRETEIYQTVLMRHENI 93 Query: 326 VQLY-----AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 + S +Y++T+Y GSL D+LK T L ++ +A SG+ ++ Sbjct: 94 LGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTT---LDAKSMLKLAYSSVSGLCHL 150 Query: 381 E--------RMNYVHRDLRAANILVGENLVCKVADFGLA-RLIEDNEYTA--RQGAKFPI 429 + HRDL++ NILV +N C +AD GLA + I D Sbjct: 151 HTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTK 210 Query: 430 KWTAPEAA---LYGRF---TIKSDVWSFGILLTELTTKG---------RVPYPGMVN--- 471 ++ PE L I +D++SFG++L E+ + ++PY +V Sbjct: 211 RYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDP 270 Query: 472 --REVLDQV-ERGYRMPCP-----PECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 ++ + V + R P EC + LM +CW P R T ++ L Sbjct: 271 SYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMS 330 Query: 524 TSTE 527 S + Sbjct: 331 ESQD 334 >2ZMD-A nrPDB Length = 390 Score = 184 bits (467), Expect = 8e-47, Method: Composition-based stats. Identities = 55/269 (20%), Positives = 116/269 (43%), Gaps = 25/269 (9%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAF---LQEAQVMKKLR--HEK 324 + ++G G +V+ AIK + + E + KL+ +K Sbjct: 58 YSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDK 117 Query: 325 LVQLYAV-VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 +++LY ++++ IY+V E L +LK + K + + + + + + Sbjct: 118 IIRLYDYEITDQYIYMVME-CGNIDLNSWLKKK--KSIDPWERKSYWKNMLEAVHTIHQH 174 Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRF 442 VH DL+ AN L+ + + K+ DFG+A ++ D + + + PEA Sbjct: 175 GIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAIKDMSS 233 Query: 443 TIK-----------SDVWSFGILLTELTTKGRVPYPGMVNR--EVLDQVERGYRMPCPPE 489 + + SDVWS G +L + T G+ P+ ++N+ ++ ++ + + P Sbjct: 234 SRENGKSKSKISPKSDVWSLGCILYYM-TYGKTPFQQIINQISKLHAIIDPNHEIEFPDI 292 Query: 490 CPESLHDLMCQCWRKEPEERPTFEYLQAF 518 + L D++ C +++P++R + L A Sbjct: 293 PEKDLQDVLKCCLKRDPKQRISIPELLAH 321 >4MWI-A nrPDB Length = 294 Score = 184 bits (466), Expect = 1e-46, Method: Composition-based stats. Identities = 58/257 (22%), Positives = 115/257 (44%), Gaps = 24/257 (9%) Query: 285 WMGTWNGTTRVAIKTLKPGT-----MSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIY- 338 + G ++ VAIK K + + F +E + MKK +++++ + +E + Sbjct: 41 YKGEYH-RAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTP 99 Query: 339 ----IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY--VHRDLRA 392 IV EY G+L + L E L L + + + A G+ + +H +R+ Sbjct: 100 PQFSIVMEYCELGTLRELLDREKD--LTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRS 157 Query: 393 ANILVGENLVCKVADFGLARL---IEDNEYTARQGAKFPIKWTAP---EAALYGRFTIKS 446 +N LV + K+A F L + + + + +P E Y + +KS Sbjct: 158 SNFLVTQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQ-YDVKS 216 Query: 447 DVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESLHDLMCQCWRKE 505 +++SFGI+L E+ T G +P+ G + ++ V + + P +CP L +++ +C + Sbjct: 217 EIYSFGIVLWEIAT-GDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHD 275 Query: 506 PEERPTFEYLQAFLEDY 522 P RP+ + + L + Sbjct: 276 PSVRPSVDEILKKLSTF 292 >3BGP-A nrPDB Length = 333 Score = 184 bits (466), Expect = 1e-46, Method: Composition-based stats. Identities = 62/266 (23%), Positives = 105/266 (39%), Gaps = 27/266 (10%) Query: 267 RESLRLEVKLGQGCFGEVWMG-TWNGTTRVAIKTLKPGTMSP-------EAFLQEAQVMK 318 ++ LG G FG V+ G + VAIK ++ +S E ++K Sbjct: 55 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 114 Query: 319 KLRHEK--LVQLYAVVSE-EPIYIVTEY-MSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 374 K+ +++L + ++ E L DF+ L+ Q+ Sbjct: 115 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVL 172 Query: 375 SGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 433 + + +HRD++ NIL+ K+ DFG L++D YT G + ++ Sbjct: 173 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---YSP 229 Query: 434 PEAALYGRF-TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE 492 PE Y R+ + VWS GILL ++ G +P+ E +++ RG Sbjct: 230 PEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF------EHDEEIIRGQVF-FRQRVSS 281 Query: 493 SLHDLMCQCWRKEPEERPTFEYLQAF 518 L+ C P +RPTFE +Q Sbjct: 282 ECQHLIRWCLALRPSDRPTFEEIQNH 307 >2RIO-A nrPDB Length = 434 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 68/294 (23%), Positives = 123/294 (41%), Gaps = 41/294 (13%) Query: 273 EVKLGQGCFGEV-WMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR-HEKLVQLYA 330 E LG G G V + G++ G VA+K + + L E +++ + H +++ Y Sbjct: 20 EKILGYGSSGTVVFQGSFQGRP-VAVKRMLID--FCDIALMEIKLLTESDDHPNVIRYYC 76 Query: 331 V-VSEEPIYIVTEYMSKGSLLDFLKG-----ETGKYLRLPQLVDMAAQIASGMAYVERMN 384 ++ +YI E + +L D ++ E K + + + QIASG+A++ + Sbjct: 77 SETTDRFLYIALELCNL-NLQDLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHSLK 135 Query: 385 YVHRDLRAANILVG-------------ENLVCKVADFGLARLIEDNEYTARQGA---KFP 428 +HRDL+ NILV ENL ++DFGL + ++ + + R Sbjct: 136 IIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSGT 195 Query: 429 IKWTAPEAAL-------YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNRE--VLDQVE 479 W APE R T D++S G + + +KG+ P+ +RE ++ + Sbjct: 196 SGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIRGIF 255 Query: 480 RGYRMPCPPECP--ESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQ 531 M C + DL+ Q +P +RPT ++ F + + Sbjct: 256 SLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTA--MKVLRHPLFWPKSKKLE 307 >5USZ-A nrPDB Length = 289 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 72/282 (25%), Positives = 121/282 (42%), Gaps = 27/282 (9%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTT--------RVAIKTLKPGTM-SPEAFLQEA 314 +I E L LGQG F +++ G V +K L E+F + A Sbjct: 4 KIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAA 63 Query: 315 QVMKKLRHEKLVQLYAVV-SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373 +M KL H+ LV Y V + +V E++ GSL +LK + + +++A Q+ Sbjct: 64 SMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKN-CINILWKLEVAKQL 122 Query: 374 ASGMAYVERMNYVHRDLRAANILV--------GENLVCKVADFGLARLIEDNEYTARQGA 425 A+ M ++E +H ++ A NIL+ G K++D G++ + + + Sbjct: 123 AAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQER-- 180 Query: 426 KFPIKWTAPEAALY-GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM 484 I W PE + +D WSFG L E+ + G P + ++ L E +++ Sbjct: 181 ---IPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQL 237 Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 P P L +L+ C EP+ RP+F + L FT Sbjct: 238 PAPK--AAELANLINNCMDYEPDHRPSFRAIIRDLNSLFTPD 277 >6O6Q-A nrPDB Length = 335 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 64/338 (18%), Positives = 126/338 (37%), Gaps = 61/338 (18%) Query: 233 YSKHADGLCHRLTTVCPTSKPQTQGLAKD---AWEIPRESLRLEVKLGQGCFGEVWMGTW 289 + + R+ ++KPQ+ D W P+E+ + KLG+G + EV++G Sbjct: 4 HRHNTVQSVSRVYADVLSTKPQSYWDYDDLNIKWN-PQENYEILRKLGRGKYSEVFLGID 62 Query: 290 -NGTTRVAIKTLKPGTMSPEAFLQEAQVMKKL-RHEKLVQLYAVVSEEPIYIVTEYMSKG 347 +V IK LKP + + +E ++K L ++ + VV E + + G Sbjct: 63 LEKREKVVIKVLKP--VKRKKIKREISILKNLVDGPNIIAMLDVVREP------QSKTPG 114 Query: 348 SLLDFLKGETGK----YLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGEN-LV 402 + + + + + ++ + Y M +HRD++ N+++ + + Sbjct: 115 LIFEHINNIDFRSLYPTFTDYDIRFYMYELLKALDYSHSMGIMHRDVKPHNVMIDHDKKL 174 Query: 403 CKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTT 460 ++ D+GLA EY R +++ + PE + Y + D+WSFG +L + Sbjct: 175 LRLIDWGLAEYYHPGTEYNVRVASRY---FKGPELLVDYRLYDYSLDMWSFGCMLASMVF 231 Query: 461 KGRVPYPGMVNREVLDQVERGYRMPCPPE------------------------------- 489 + G N + L Q+ R + Sbjct: 232 MKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKYNISLGEEYEDIGYYNKRQWVRFMNEN 291 Query: 490 ----CPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 + DL+ + R + +ER T + A YF Sbjct: 292 NKDLVSQEFLDLIDRLLRYDHQERLTAKE--AMKHAYF 327 >5TUR-A nrPDB Length = 404 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 62/266 (23%), Positives = 105/266 (39%), Gaps = 27/266 (10%) Query: 267 RESLRLEVKLGQGCFGEVWMG-TWNGTTRVAIKTLKPGTMSP-------EAFLQEAQVMK 318 ++ LG G FG V+ G + VAIK ++ +S E ++K Sbjct: 126 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 185 Query: 319 KLRHEK--LVQLYAVVSE-EPIYIVTEY-MSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 374 K+ +++L + ++ E L DF+ L+ Q+ Sbjct: 186 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVL 243 Query: 375 SGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 433 + + +HRD++ NIL+ K+ DFG L++D YT G + ++ Sbjct: 244 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---YSP 300 Query: 434 PEAALYGRF-TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE 492 PE Y R+ + VWS GILL ++ G +P+ E +++ RG Sbjct: 301 PEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF------EHDEEIIRGQVF-FRQRVSS 352 Query: 493 SLHDLMCQCWRKEPEERPTFEYLQAF 518 L+ C P +RPTFE +Q Sbjct: 353 ECQHLIRWCLALRPSDRPTFEEIQNH 378 >4L00-A nrPDB Length = 304 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 71/280 (25%), Positives = 116/280 (41%), Gaps = 29/280 (10%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTW-----------NGTTRVAIKTLKPGTMSPE-AFL 311 I ++ L LG+G ++ GT +V +K L P AF Sbjct: 21 RILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFF 80 Query: 312 QEAQVMKKLRHEKLVQLYAVVSEE-PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMA 370 + A +M+++ H+ +V LY V + +V E++ G L D L P +A Sbjct: 81 EAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPL-DLFMHRKSDVLTTPWKFKVA 139 Query: 371 AQIASGMAYVERMNYVHRDLRAANILVGENLV-------CKVADFGLARLIEDNEYTARQ 423 Q+AS ++Y+E + VH ++ N+L+ + K++D G+ +RQ Sbjct: 140 KQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGI-----PITVLSRQ 194 Query: 424 GAKFPIKWTAPEAALYGR-FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY 482 I W APE + ++ +D WSFG L E+ G +P E E Sbjct: 195 ECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRC 254 Query: 483 RMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 R P P C + L DLM +C +P +RP F + + Sbjct: 255 R-PVTPSC-KELADLMTRCMNYDPNQRPFFRAIMRDINKL 292 >4RC3-A nrPDB Length = 289 Score = 182 bits (463), Expect = 3e-46, Method: Composition-based stats. Identities = 62/266 (23%), Positives = 105/266 (39%), Gaps = 27/266 (10%) Query: 267 RESLRLEVKLGQGCFGEVWMG-TWNGTTRVAIKTLKPGTMSP-------EAFLQEAQVMK 318 ++ LG G FG V+ G + VAIK ++ +S E ++K Sbjct: 11 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 70 Query: 319 KLRHEK--LVQLYAVVSE-EPIYIVTEY-MSKGSLLDFLKGETGKYLRLPQLVDMAAQIA 374 K+ +++L + ++ E L DF+ L+ Q+ Sbjct: 71 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVL 128 Query: 375 SGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 433 + + +HRD++ NIL+ K+ DFG L++D YT G + ++ Sbjct: 129 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---YSP 185 Query: 434 PEAALYGRF-TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPE 492 PE Y R+ + VWS GILL ++ G +P+ E +++ RG Sbjct: 186 PEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF------EHDEEIIRGQVF-FRQRVSS 237 Query: 493 SLHDLMCQCWRKEPEERPTFEYLQAF 518 L+ C P +RPTFE +Q Sbjct: 238 ECQHLIRWCLALRPSDRPTFEEIQNH 263 >1S9I-A nrPDB Length = 354 Score = 182 bits (462), Expect = 3e-46, Method: Composition-based stats. Identities = 71/334 (21%), Positives = 122/334 (36%), Gaps = 70/334 (20%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSP---EAFLQEAQVMKKL 320 E+ + +LG G G V + + + L + P ++E QV+ + Sbjct: 12 ELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHEC 71 Query: 321 RHEKLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 +V Y S+ I I E+M GSL LK K + L ++ + G+AY Sbjct: 72 NSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKE--AKRIPEEILGKVSIAVLRGLAY 129 Query: 380 V-ERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 438 + E+ +HRD++ +NILV K+ DFG++ + D+ + G + + APE Sbjct: 130 LREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRS---YMAPERLQ 186 Query: 439 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNRE------------------------- 473 ++++SD+WS G+ L EL GR P P +E Sbjct: 187 GTHYSVQSDIWSMGLSLVELAV-GRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRPR 245 Query: 474 ------------------VLDQVERGYRMPCPPE----CPESLHDLMCQCWRKEPEERPT 511 + + ++ P P + + +C K P ER Sbjct: 246 PPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLIKNPAERAD 305 Query: 512 FEYL--QAFLED----------YFTSTEPQYQPG 533 + L F++ + T QPG Sbjct: 306 LKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPG 339 >3Q4U-A nrPDB Length = 301 Score = 182 bits (461), Expect = 5e-46, Method: Composition-based stats. Identities = 75/300 (25%), Positives = 128/300 (42%), Gaps = 52/300 (17%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK--KLRHEKL 325 + L +G+G +GEVW G+W G VA+K + +++ +E ++ LRHE + Sbjct: 8 RDITLLECVGKGRYGEVWRGSWQGEN-VAVKIF--SSRDEKSWFRETELYNTVMLRHENI 64 Query: 326 VQLYAVV-----SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 + A S ++++T Y GSL D+L+ T L + + IASG+A++ Sbjct: 65 LGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTT---LDTVSCLRIVLSIASGLAHL 121 Query: 381 E--------RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG---AKFPI 429 + HRDL++ NILV +N C +AD GLA + + G Sbjct: 122 HIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTK 181 Query: 430 KWTAPEAA-------LYGRFTIKSDVWSFGILLTE----LTTKG-----RVPYPGMVNRE 473 ++ APE + + + D+W+FG++L E + + G + P+ +V + Sbjct: 182 RYMAPEVLDETIQVDCFDSY-KRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPND 240 Query: 474 --VLDQVERGYRMPCPPECP---------ESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 D + P P SL LM +CW + P R T ++ L Sbjct: 241 PSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKI 300 >2WO6-A nrPDB Length = 382 Score = 181 bits (460), Expect = 5e-46, Method: Composition-based stats. Identities = 53/261 (20%), Positives = 104/261 (39%), Gaps = 30/261 (11%) Query: 267 RESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLR-HE- 323 + ++ +G+G FG+V VAIK +K E ++++ + H+ Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDT 112 Query: 324 ----KLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378 +V L + + +V E +S +L D L+ + + L A Q+ + + Sbjct: 113 EMKYYIVHLKRHFMFRNHLCLVFEMLS-YNLYDLLRNTNFRGVSLNLTRKFAQQMCTALL 171 Query: 379 YVE--RMNYVHRDLRAANILVGE--NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 434 ++ ++ +H DL+ NIL+ K+ DFG + + Y Q + +P Sbjct: 172 FLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSR----FYRSP 227 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESL 494 E L + + D+WS G +L E+ T G + G + ++++ +P Sbjct: 228 EVLLGMPYDLAIDMWSLGCILVEMHT-GEPLFSGANEVDQMNKIVEVLGIPP-------- 278 Query: 495 HDLMCQCWRKEPEERPTFEYL 515 + P+ R FE L Sbjct: 279 ----AHILDQAPKARKFFEKL 295 >6CKI-A nrPDB Length = 316 Score = 181 bits (460), Expect = 6e-46, Method: Composition-based stats. Identities = 53/282 (18%), Positives = 105/282 (37%), Gaps = 39/282 (13%) Query: 273 EVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMS-PEAFLQEAQVMKKLR-HEKLVQLY 329 E LG+G V T A+K ++ +E +++ + + H +++L Sbjct: 18 EDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELI 77 Query: 330 AVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 E + Y+V E M GS+L + ++ + + +AS + ++ HR Sbjct: 78 EFFEEEDRFYLVFEKMRGGSILSHIHKR--RHFNELEASVVVQDVASALDFLHNKGIAHR 135 Query: 389 DLRAANILVGENLV---CKVADFGLARLIEDNEYTARQGAK------FPIKWTAPEAA-- 437 DL+ NIL K+ DFGL I+ N + ++ APE Sbjct: 136 DLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEA 195 Query: 438 ---LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNRE---------------VLDQVE 479 + + D+WS G++L L + G P+ G + + + ++ Sbjct: 196 FSEEASIYDKRCDLWSLGVILYILLS-GYPPFVGRCGSDCGWDRGEACPACQNMLFESIQ 254 Query: 480 RG-YRMP--CPPECPESLHDLMCQCWRKEPEERPTFEYLQAF 518 G Y P + DL+ + ++ ++R + + Sbjct: 255 EGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQH 296 >4IDT-A nrPDB Length = 356 Score = 180 bits (456), Expect = 2e-45, Method: Composition-based stats. Identities = 59/250 (23%), Positives = 95/250 (38%), Gaps = 16/250 (6%) Query: 275 KLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS 333 +LG+G FGEV T + A+K ++ E E L ++V LY V Sbjct: 81 RLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAE----ELMACAGLTSPRIVPLYGAVR 136 Query: 334 EEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRA 392 E P + I E + GSL +K + L + + Q G+ Y+ +H D++A Sbjct: 137 EGPWVNIFMELLEGGSLGQLVKEQGC--LPEDRALYYLGQALEGLEYLHSRRILHGDVKA 194 Query: 393 ANILVGENL-VCKVADFGLARLIEDNEYTARQGAK----FPIKWTAPEAALYGRFTIKSD 447 N+L+ + + DFG A ++ + APE L K D Sbjct: 195 DNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGRSCDAKVD 254 Query: 448 VWSFGILLTELTTKGRVPYPGMVNREVLDQV--ERGYRMPCPPECPESLHDLMCQCWRKE 505 VWS ++ + G P+ + ++ E PP C + + RKE Sbjct: 255 VWSSCCMMLHML-NGCHPWTQFFRGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKE 313 Query: 506 PEERPTFEYL 515 P R + L Sbjct: 314 PIHRVSAAEL 323 >1PY5-A nrPDB Length = 326 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 73/320 (22%), Positives = 134/320 (41%), Gaps = 50/320 (15%) Query: 247 VCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMS 306 T+ GL ++ L+ +G+G FGEVW G W G VA+K + Sbjct: 8 YDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRG-EEVAVKIF--SSRE 64 Query: 307 PEAFLQEAQVMK--KLRHEKLVQLYAVVSEEP-----IYIVTEYMSKGSLLDFLKGETGK 359 ++ +EA++ + LRHE ++ A +++ +++V++Y GSL D+L T Sbjct: 65 ERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYT-- 122 Query: 360 YLRLPQLVDMAAQIASGMAYVE--------RMNYVHRDLRAANILVGENLVCKVADFGLA 411 + + ++ +A ASG+A++ + HRDL++ NILV +N C +AD GLA Sbjct: 123 -VTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLA 181 Query: 412 RLIEDNEYT---ARQGAKFPIKWTAPEA----ALYGRFT--IKSDVWSFGILLTELTTKG 462 + T A ++ APE F ++D+++ G++ E+ + Sbjct: 182 VRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRC 241 Query: 463 ---------RVPYPGMVNRE--VLDQVERGYRMPCPPECP---------ESLHDLMCQCW 502 ++PY +V + V + + P P + +M +CW Sbjct: 242 SIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECW 301 Query: 503 RKEPEERPTFEYLQAFLEDY 522 R T ++ L Sbjct: 302 YANGAARLTALRIKKTLSQL 321 >4TN6-A nrPDB Length = 318 Score = 179 bits (454), Expect = 3e-45, Method: Composition-based stats. Identities = 60/273 (21%), Positives = 113/273 (41%), Gaps = 19/273 (6%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLV 326 RL K+G G FG++++GT VAIK T P+ + E+++ K ++ + Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHI-ESKIYKMMQGGVGI 65 Query: 327 QLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 E Y V G L+ L + L ++ +A Q+ S + Y+ N++ Sbjct: 66 PTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFI 125 Query: 387 HRDLRAANILVG---ENLVCKVADFGLARLIEDNE------YTARQGAKFPIKWTAPEAA 437 HRD++ N L+G + + + DFGLA+ D Y + ++ + Sbjct: 126 HRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTH 185 Query: 438 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGM---VNREVLDQV-ERGYRMPCPPEC--- 490 L + + D+ S G +L G +P+ G+ R+ +++ E+ P C Sbjct: 186 LGIEQSRRDDLESLGYVLMY-FNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGY 244 Query: 491 PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 P + C +++P + YL+ + F Sbjct: 245 PSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLF 277 >4M66-A nrPDB Length = 325 Score = 179 bits (453), Expect = 4e-45, Method: Composition-based stats. Identities = 72/274 (26%), Positives = 116/274 (42%), Gaps = 31/274 (11%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHE 323 + RE L+ +G+G FG V+ VA+K + +S E + M LR+E Sbjct: 17 VSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKIS-----WEVKAMVNLRNE 71 Query: 324 KLVQLYAVVSE------EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 ++ L V + +VT +M GSL L+ E + P L + ++ GM Sbjct: 72 NVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPRP--WPLLCRLLQEVVLGM 129 Query: 378 AYVERMN--YVHRDLRAANILVGENLVCKVADFGLARL-----IEDNEYTARQGAKFPIK 430 Y+ ++ +HRDL+ +NIL+ L K+ADFGL+ + + + + Sbjct: 130 CYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLA 189 Query: 431 WTAPEAAL--YGRFTIKSDVWSFGILLTELTTKGRVPYPGMV---NREVLDQVERGYRMP 485 + PE + + SDV+SFGIL+ + V D+ R Sbjct: 190 YLDPELLFKVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQSRPPLTE 249 Query: 486 CPPECP-----ESLHDLMCQCWRKEPEERPTFEY 514 PP P E L +LM CW + E RP+F+ Sbjct: 250 LPPGSPETPGLEKLKELMIHCWGSQSENRPSFQD 283 >5VD3-A nrPDB Length = 311 Score = 179 bits (453), Expect = 4e-45, Method: Composition-based stats. Identities = 72/308 (23%), Positives = 121/308 (39%), Gaps = 24/308 (7%) Query: 218 TSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLG 277 T F S+ + + R P +++ ++S + +LG Sbjct: 15 TENLYFQSM------HQLQPRRVSFRGEASETLQSPGYDPSRPESFF--QQSFQRLSRLG 66 Query: 278 QGCFGEVWMGTWNGTTR-VAIKT-LKPGTMSPEAFLQEAQV---MKKLRHEKLVQLYAVV 332 G +GEV+ R A+K + P + + A+V K +H V+L Sbjct: 67 HGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAW 126 Query: 333 SEEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLR 391 E +Y+ TE SL + G L Q+ +A++ VH D++ Sbjct: 127 EEGGILYLQTELC-GPSLQQHCEAW-GASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVK 184 Query: 392 AANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 451 ANI +G CK+ DFGL L+E A + + ++ APE L G + +DV+S Sbjct: 185 PANIFLGPRGRCKLGDFGL--LVELGTAGAGEVQEGDPRYMAPE-LLQGSYGTAADVFSL 241 Query: 452 GILLTELTTKGRVPYPGMVNREVLDQVERGYRMP-CPPECPESLHDLMCQCWRKEPEERP 510 G+ + E+ +P+ G E Q+ +GY P L ++ +P+ R Sbjct: 242 GLTILEVACNMELPHGG----EGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRA 297 Query: 511 TFEYLQAF 518 T E L A Sbjct: 298 TAEALLAL 305 >3E3P-A nrPDB Length = 360 Score = 179 bits (453), Expect = 4e-45, Method: Composition-based stats. Identities = 72/325 (22%), Positives = 113/325 (34%), Gaps = 71/325 (21%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKL---R 321 + ++E GQG FG V +G T VAIK + +E Q+M+ L Sbjct: 21 EMDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRN---RELQIMQDLAVLH 77 Query: 322 HEKLVQLYAVV------SEEPIYI--VTEYMSKGSLLDFLKGETGKYLRLP------QLV 367 H +VQL + IY+ V EY+ D L Y R + Sbjct: 78 HPNIVQLQSYFYTLGERDRRDIYLNVVMEYVP-----DTLHRCCRNYYRRQVAPPPILIK 132 Query: 368 DMAAQIASGMAYVE--RMNYVHRDLRAANILVGE-NLVCKVADFGLARLIEDNEYTARQG 424 Q+ + + +N HRD++ N+LV E + K+ DFG A+ + +E Sbjct: 133 VFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVAYI 192 Query: 425 AKFPIKWTAPEAALY-GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYR 483 + APE +T D+WS G + E+ G + G + L ++ R Sbjct: 193 C--SRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMM-LGEPIFRGDNSAGQLHEIVRVLG 249 Query: 484 MPC------------------PPECP-------------ESLHDLMCQCWRKEPEERPT- 511 P P + +DL+ + PEER Sbjct: 250 CPSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKP 309 Query: 512 FEYLQAFLEDYFTSTEPQYQPGENL 536 +E L YF + + P L Sbjct: 310 YEALC---HPYF---DELHDPATKL 328 >5FQD-C nrPDB Length = 341 Score = 177 bits (450), Expect = 9e-45, Method: Composition-based stats. Identities = 63/283 (22%), Positives = 114/283 (40%), Gaps = 19/283 (6%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTW-NGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHE 323 I +L K+G G FG++++ VA+K P+ L E+++ K L+ Sbjct: 16 IVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQ-LLYESKLYKILQGG 74 Query: 324 KLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 + +E Y V G L+ L + + ++ +A Q+ S + YV Sbjct: 75 VGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTK 134 Query: 384 NYVHRDLRAANILVGENLVCK---VADFGLARLIEDNE------YTARQGAKFPIKWTAP 434 N++HRD++ N L+G C + DFGLA+ DN Y + ++ + Sbjct: 135 NFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASI 194 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM---VNREVLDQV-ERGYRMPCPPEC 490 A L + + D+ S G +L + +P+ G+ ++ +++ E+ P C Sbjct: 195 NAHLGIEQSRRDDMESLGYVLMY-FNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLC 253 Query: 491 ---PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 P + C EE P + YL+ F + QY Sbjct: 254 KGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQY 296 >5VC6-A nrPDB Length = 289 Score = 177 bits (449), Expect = 1e-44, Method: Composition-based stats. Identities = 58/280 (20%), Positives = 108/280 (38%), Gaps = 39/280 (13%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWN-GTTRVAIKTLKP---GTMSPEAFLQEAQVMKKL-RH 322 K+G G FG V+ AIK K G++ + L+E L +H Sbjct: 11 TEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQH 70 Query: 323 EKLVQLYAVVSEEPIYIVT-EYMSKGSLLDFLKG--ETGKYLRLPQLVDMAAQIASGMAY 379 +V+ ++ +E+ ++ EY + GSL D + Y + +L D+ Q+ G+ Y Sbjct: 71 SHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRY 130 Query: 380 VERMNYVHRDLRAANILVGENLVC-------------------KVADFGLARLIEDNEYT 420 + M+ VH D++ +NI + + K+ D G + Sbjct: 131 IHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLG-----HVTRIS 185 Query: 421 ARQGAKFPIKWTAPEAALYGRFTI--KSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 + Q + ++ A E +T K+D+++ LT + G P P N + ++ Sbjct: 186 SPQVEEGDSRFLANEVL-QENYTHLPKADIFALA--LTVVCAAGAEPLP--RNGDQWHEI 240 Query: 479 ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAF 518 +G P + +L+ +PE RP+ L Sbjct: 241 RQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKH 280 >4M4Z-A nrPDB Length = 170 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 65/162 (40%), Positives = 92/162 (56%), Gaps = 5/162 (3%) Query: 87 TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSI 146 T VAL + + +LS + GE L IV+ +GDWW S +G+ IPS +VA Sbjct: 12 ATAVALGSFPAGGPAELSLRLGEPLTIVSE-DGDWWTVLSEVSGREYNIPSVHVAKV--- 67 Query: 147 QAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYK 206 + W + ++R ++E LLL NP G FL+RES+T +G+Y LSV A ++HY+ Sbjct: 68 -SHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYR 126 Query: 207 IRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC 248 I LD+G YI+ R F SLQ LV +YS+ AD +C L C Sbjct: 127 IHCLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPC 168 >3M42-A nrPDB Length = 299 Score = 175 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 52/264 (19%), Positives = 94/264 (35%), Gaps = 49/264 (18%) Query: 274 VKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQEAQVM-KKLRHEKLVQLYAV 331 LG G G+V T + A+K L +E ++ + + +V++ V Sbjct: 24 QVLGLGINGKVLQIFNKRTQEKFALKML----QDCPKARREVELHWRASQCPHIVRIVDV 79 Query: 332 VS-----EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 + + IV E + G L ++ + + ++ I + Y+ +N Sbjct: 80 YENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIA 139 Query: 387 HRDLRAANILVGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443 HRD++ N+L N + K+ DFG A+ ++ Sbjct: 140 HRDVKPENLLYTSKRPNAILKLTDFGFAKETT-----------------------GEKYD 176 Query: 444 IKSDVWSFGILLTELTTKGRVPY---------PGMVNREVLDQVERGYRMPCPPECPESL 494 D+WS G+++ L G P+ PGM R + Q E + P E E + Sbjct: 177 KSCDMWSLGVIMYILLC-GYPPFYSNHGLAISPGMKTRIRMGQYE--FPNPEWSEVSEEV 233 Query: 495 HDLMCQCWRKEPEERPTFEYLQAF 518 L+ + EP +R T Sbjct: 234 KMLIRNLLKTEPTQRMTITEFMNH 257 >3RAW-A nrPDB Length = 381 Score = 175 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 72/335 (21%), Positives = 114/335 (34%), Gaps = 81/335 (24%) Query: 267 RESLRLEVKLGQGCFGEV--WMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324 +E + LG+G FG+V + G ++VA+K ++ EA E V+KK++ + Sbjct: 50 QERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKD 109 Query: 325 ------LVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 V + + + I E + + +FLK + LP + MA Q+ + Sbjct: 110 KENKFLCVLMSDWFNFHGHMCIAFELL-GKNTFEFLKENNFQPYPLPHVRHMAYQLCHAL 168 Query: 378 AYVERMNYVHRDLRAANILVGE-------------------NLVCKVADFGLARLIEDNE 418 ++ H DL+ NIL N +VADFG A ++ Sbjct: 169 RFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHH 228 Query: 419 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 T + PE L + DVWS G +L E +G + NRE L + Sbjct: 229 TTI----VATRHYRPPEVILELGWAQPCDVWSIGCILFE-YYRGFTLFQTHENREHLVMM 283 Query: 479 ERGYRMPCPP-------------------------------ECPE-------------SL 494 E+ P P C L Sbjct: 284 EKILG-PIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQL 342 Query: 495 HDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 DLM + +P +R T A L +F P+ Sbjct: 343 FDLMRRMLEFDPAQRITLAE--ALLHPFFAGLTPE 375 >3MY0-A nrPDB Length = 305 Score = 174 bits (440), Expect = 1e-43, Method: Composition-based stats. Identities = 74/305 (24%), Positives = 126/305 (41%), Gaps = 52/305 (17%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKK--LRHEKL 325 + L +G+G +GEVW G W+G VA+K + +++ +E ++ LRH+ + Sbjct: 8 RQVALVECVGKGRYGEVWRGLWHG-ESVAVKIF--SSRDEQSWFRETEIYNTVLLRHDNI 64 Query: 326 VQLYAVV-----SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 + A S ++++T Y GSL DFL+ +T L + +A A G+A++ Sbjct: 65 LGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQT---LEPHLALRLAVSAACGLAHL 121 Query: 381 E--------RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG---AKFPI 429 + HRD ++ N+LV NL C +AD GLA + G Sbjct: 122 HVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRVGTK 181 Query: 430 KWTAPEAA-------LYGRFTIKSDVWSFGILLTEL----TTKG-----RVPYPGMVNRE 473 ++ APE + + +D+W+FG++L E+ G R P+ +V + Sbjct: 182 RYMAPEVLDEQIRTDCFESYKW-TDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVVPND 240 Query: 474 --VLDQVERGYRMPCPPECP---------ESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 D + P P L +M +CW P R T ++ L+ Sbjct: 241 PSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKI 300 Query: 523 FTSTE 527 S E Sbjct: 301 SNSPE 305 >5E8V-A nrPDB Length = 316 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 66/303 (21%), Positives = 125/303 (41%), Gaps = 55/303 (18%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTT-----RVAIKTLKPGTMSPEAFLQEAQVMK--KLRH 322 + L+ +G+G F EV+ T VA+K + ++ E + L+H Sbjct: 11 IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYA--SWKTEKDIFSDINLKH 68 Query: 323 EKLVQLYAVVSEE-----PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 E ++Q + +++T + +KG+L ++L T + L + + +A G+ Sbjct: 69 ENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYL---TRHVISWEDLRKLGSSLARGI 125 Query: 378 AYVER---------MNYVHRDLRAANILVGENLVCKVADFGLARLIEDN---EYTARQGA 425 A++ M VHRDL+++NILV +L C + DFGL+ ++ + A G Sbjct: 126 AHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQ 185 Query: 426 KFPIKWTAPEAA-----LYGRFTIK-SDVWSFGILLTELTTKG---------RVPYPGMV 470 ++ APE L + K +DV+S ++L E+T++ P+ V Sbjct: 186 VGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKV 245 Query: 471 NRE--VLDQVERGYRMPCPPECP---------ESLHDLMCQCWRKEPEERPTFEYLQAFL 519 V + PE P + + + + +CW +PE R T + + Sbjct: 246 REHPCVASMADNVLADAGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERF 305 Query: 520 EDY 522 + Sbjct: 306 SEL 308 >4G3E-A nrPDB Length = 352 Score = 172 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 56/252 (22%), Positives = 95/252 (37%), Gaps = 16/252 (6%) Query: 275 KLGQGCFGEVWMGTWNGTT-RVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS 333 ++G+G FGEV T + A+K ++ E E L ++V LY V Sbjct: 81 RVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVE----ELVACAGLSSPRIVPLYGAVR 136 Query: 334 EEP-IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRA 392 E P + I E + GSL +K L + + Q G+ Y+ +H D++A Sbjct: 137 EGPWVNIFMELLEGGSLGQLIK--QMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKA 194 Query: 393 ANILVGENLV-CKVADFGLARLIEDNEYTARQGAK----FPIKWTAPEAALYGRFTIKSD 447 N+L+ + + DFG A ++ + APE + K D Sbjct: 195 DNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAKVD 254 Query: 448 VWSFGILLTELTTKGRVPYPGMVNREVLDQV--ERGYRMPCPPECPESLHDLMCQCWRKE 505 +WS ++ + G P+ + ++ E PP C + + RKE Sbjct: 255 IWSSCCMMLHML-NGCHPWTQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKE 313 Query: 506 PEERPTFEYLQA 517 P R + L+ Sbjct: 314 PVHRASAMELRR 325 >3SV0-A nrPDB Length = 483 Score = 172 bits (437), Expect = 3e-43, Method: Composition-based stats. Identities = 61/273 (22%), Positives = 112/273 (41%), Gaps = 19/273 (6%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLV 326 RL K+G G FGE+++GT T VAIK T P+ L E+++ + L+ + Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKLENVKTKHPQ-LLYESKIYRILQGGTGI 65 Query: 327 QLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 E Y V G L+ L + L L ++ +A Q+ + + +V +++ Sbjct: 66 PNVRWFGVEGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLMLADQMINRVEFVHSKSFL 125 Query: 387 HRDLRAANILVG---ENLVCKVADFGLARLIEDNE------YTARQGAKFPIKWTAPEAA 437 HRD++ N L+G + DFGLA+ D Y + ++ + Sbjct: 126 HRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTGTARYASVNTH 185 Query: 438 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGM---VNREVLDQV-ERGYRMPCPPEC--- 490 L + + D+ S G +L +G +P+ G+ ++ +++ E+ C Sbjct: 186 LGIEQSRRDDLESLGYVLMYFL-RGSLPWQGLKAGTKKQKYEKISEKKVATSIEALCRGY 244 Query: 491 PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 P C +++P + YL+ D F Sbjct: 245 PTEFASYFHYCRSLRFDDKPDYSYLKRLFRDLF 277 >4IAN-A nrPDB Length = 358 Score = 172 bits (436), Expect = 3e-43, Method: Composition-based stats. Identities = 56/212 (26%), Positives = 98/212 (46%), Gaps = 16/212 (7%) Query: 277 GQGCFGEVWMGTW--NGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHE------KLVQL 328 GQG F V VA+K ++ + + L+E + +KKL ++L Sbjct: 39 GQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRL 98 Query: 329 YA-VVSEEPIYIVTEYMSKGSLLDFLKGE-TGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 + ++ + +V E +S +L + LK L + + + Q+ + ++R N + Sbjct: 99 FRHFYHKQHLCLVFEPLSM-NLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNIL 157 Query: 387 HRDLRAANILVGENLVC-KVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445 H D++ NILV E+ K+ DFG A + DN+ T ++F + APE + + Sbjct: 158 HADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRF---YRAPEIIIGKSYDYG 214 Query: 446 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQ 477 D+WS G L EL T G++ +PG N +L Sbjct: 215 IDMWSVGCTLYELYT-GKILFPGKTNNHMLKL 245 >3EB0-A nrPDB Length = 383 Score = 171 bits (434), Expect = 5e-43, Method: Composition-based stats. Identities = 64/341 (18%), Positives = 114/341 (33%), Gaps = 81/341 (23%) Query: 270 LRLEVKLGQGCFGEVWMGTW-NGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQL 328 L LG G FG V R A+K + +E +MK L H +++L Sbjct: 9 YSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKN---RELDIMKVLDHVNIIKL 65 Query: 329 YAVV---------------------------------------SEEPIYIVTEYMSKGSL 349 + + ++ EY+ +L Sbjct: 66 VDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVP-DTL 124 Query: 350 LDFLKG--ETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE-NLVCKVA 406 LK +G+ + + + Q+ + ++ + HRD++ N+LV + K+ Sbjct: 125 HKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLC 184 Query: 407 DFGLARLIEDNEYTARQGAKFPIKWTAPEAALY-GRFTIKSDVWSFGILLTELTTKGRVP 465 DFG A+ + +E + + APE L +T D+WS G + EL G+ Sbjct: 185 DFGSAKKLIPSEPSVAYIC--SRFYRAPELMLGATEYTPSIDLWSIGCVFGELI-LGKPL 241 Query: 466 YPGMVNREVLDQVERGYRMP----------------------------CPPECPESLHDL 497 + G + + L ++ + P P P DL Sbjct: 242 FSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPSLAIDL 301 Query: 498 MCQCWRKEPEERPT-FEYL-QAFLEDYFTSTEPQYQPGENL 536 + Q R EP+ R +E + F + S E + + N Sbjct: 302 LEQILRYEPDLRINPYEAMAHPFFDHLRNSYESEVKNNSNF 342 >4JLC-A nrPDB Length = 657 Score = 171 bits (433), Expect = 9e-43, Method: Composition-based stats. Identities = 58/232 (25%), Positives = 102/232 (43%), Gaps = 24/232 (10%) Query: 272 LEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSP--EAFLQEAQVMKKLRHEKLVQL 328 L LGQG V+ G T A+K + + ++E +V+KKL H+ +V+L Sbjct: 12 LSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 71 Query: 329 YAVVSE---EPIYIVTEYMSKGSLLDFLKGETGKY-LRLPQLVDMAAQIASGMAYVERMN 384 +A+ E ++ E+ GSL L+ + Y L + + + + GM ++ Sbjct: 72 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 131 Query: 385 YVHRDLRAANIL--VGENLV--CKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL-- 438 VHRD++ NI+ +GE+ K+ DFG AR +ED+E ++ P+ Sbjct: 132 IVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE--QFVSLYGTEEYLHPDMYERA 189 Query: 439 ------YGRFTIKSDVWSFGILLTELTTKGRV--PYPG-MVNREVLDQVERG 481 ++ D+WS G+ T P+ G N+EV+ ++ G Sbjct: 190 VLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 241 >2H34-A nrPDB Length = 309 Score = 170 bits (432), Expect = 1e-42, Method: Composition-based stats. Identities = 57/248 (22%), Positives = 102/248 (41%), Gaps = 11/248 (4%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTR-VAIK----TLKPGTMSPEAFLQEAQVMKKLRHEK 324 RL +G+G G+V+ R VA+K TL + +EA+ +L+ Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDPVFRTRMQREARTAGRLQEPH 95 Query: 325 LVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 +V ++ + +Y+ ++ L L+ + L P+ V + QI S + Sbjct: 96 VVPIHDFGEIDGQLYVDMRLINGVDLAAMLRRQG--PLAPPRAVAIVRQIGSALDAAHAA 153 Query: 384 NYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443 HRD++ NILV + + DFG+A D + T + + APE T Sbjct: 154 GATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSESHAT 213 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP--CPPECPESLHDLMCQC 501 ++D+++ +L E T G PY G + + + P P P + ++ + Sbjct: 214 YRADIYALTCVLYECLT-GSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFDAVIARG 272 Query: 502 WRKEPEER 509 K PE+R Sbjct: 273 MAKNPEDR 280 >3G2F-A nrPDB Length = 336 Score = 169 bits (428), Expect = 3e-42, Method: Composition-based stats. Identities = 61/308 (19%), Positives = 118/308 (38%), Gaps = 61/308 (19%) Query: 261 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKK- 319 + ++L+L +G+G +G V+ G+ + VA+K + + F+ E + + Sbjct: 6 SEPSLDLDNLKLLELIGRGRYGAVYKGSLDERP-VAVKVF--SFANRQNFINEKNIYRVP 62 Query: 320 -LRHEKLVQLY----AVVSEEPI--YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQ 372 + H+ + + V ++ + +V EY GSL +L T +A Sbjct: 63 LMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS---DWVSSCRLAHS 119 Query: 373 IASGMAYVE---------RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDN------ 417 + G+AY+ + HRDL + N+LV + C ++DFGL+ + N Sbjct: 120 VTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPG 179 Query: 418 -EYTARQGAKFPIKWTAPEAALY-------GRFTIKSDVWSFGILLTELTTKGRVPYPGM 469 E A I++ APE + D+++ G++ E+ + +PG Sbjct: 180 EEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGE 239 Query: 470 VN-----------------REVLDQVERGYRMPCPPECPES-------LHDLMCQCWRKE 505 ++ V R + P PE + L + + CW ++ Sbjct: 240 SVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWDQD 299 Query: 506 PEERPTFE 513 E R T + Sbjct: 300 AEARLTAQ 307 >5UNP-A nrPDB Length = 369 Score = 169 bits (428), Expect = 3e-42, Method: Composition-based stats. Identities = 72/335 (21%), Positives = 108/335 (32%), Gaps = 81/335 (24%) Query: 267 RESLRLEVKLGQGCFGEVWMGTWN--GTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEK 324 +E + LG+G FG V + G RVA+K +K EA E V++K+ + Sbjct: 33 QERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKD 92 Query: 325 ------LVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 VQ++ + I E + S DFLK + Q+ MA Q+ + Sbjct: 93 PDNKNLCVQMFDWFDYHGHMCISFELL-GLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAV 151 Query: 378 AYVERMNYVHRDLRAANILVGENL-------------------VCKVADFGLARLIEDNE 418 ++ H DL+ NIL + +V DFG A ++ Sbjct: 152 KFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHH 211 Query: 419 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 T + APE L ++ DVWS G ++ E G + NRE L + Sbjct: 212 STI----VSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYV-GFTLFQTHDNREHLAMM 266 Query: 479 ERGYRMPCPP-------------------------------ECPE-------------SL 494 ER P P C L Sbjct: 267 ERILG-PIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQL 325 Query: 495 HDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQ 529 DL+ EP +R T A +F + Sbjct: 326 FDLIESMLEYEPAKRLTLGE--ALQHPFFARLRAE 358 >4EUU-A nrPDB Length = 319 Score = 169 bits (427), Expect = 4e-42, Method: Composition-based stats. Identities = 58/232 (25%), Positives = 103/232 (44%), Gaps = 24/232 (10%) Query: 272 LEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSP--EAFLQEAQVMKKLRHEKLVQL 328 L LGQG V+ G T + AIK + + ++E +V+KKL H+ +V+L Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 72 Query: 329 YAVVSE---EPIYIVTEYMSKGSLLDFLKGETGKY-LRLPQLVDMAAQIASGMAYVERMN 384 +A+ E ++ E+ GSL L+ + Y L + + + + GM ++ Sbjct: 73 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 132 Query: 385 YVHRDLRAANIL--VGENLV--CKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL-- 438 VHR+++ NI+ +GE+ K+ DFG AR +ED+E ++ P+ Sbjct: 133 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE--QFVSLYGTEEYLHPDMYERA 190 Query: 439 ------YGRFTIKSDVWSFGILLTELTTKGRV--PYPG-MVNREVLDQVERG 481 ++ D+WS G+ T P+ G N+EV+ ++ G Sbjct: 191 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 242 >4EUT-A nrPDB Length = 396 Score = 169 bits (427), Expect = 4e-42, Method: Composition-based stats. Identities = 58/232 (25%), Positives = 103/232 (44%), Gaps = 24/232 (10%) Query: 272 LEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSP--EAFLQEAQVMKKLRHEKLVQL 328 L LGQG V+ G T + AIK + + ++E +V+KKL H+ +V+L Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 72 Query: 329 YAVVSE---EPIYIVTEYMSKGSLLDFLKGETGKY-LRLPQLVDMAAQIASGMAYVERMN 384 +A+ E ++ E+ GSL L+ + Y L + + + + GM ++ Sbjct: 73 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 132 Query: 385 YVHRDLRAANIL--VGENLV--CKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL-- 438 VHR+++ NI+ +GE+ K+ DFG AR +ED+E ++ P+ Sbjct: 133 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE--QFVSLYGTEEYLHPDMYERA 190 Query: 439 ------YGRFTIKSDVWSFGILLTELTTKGRV--PYPG-MVNREVLDQVERG 481 ++ D+WS G+ T P+ G N+EV+ ++ G Sbjct: 191 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 242 >2WTK-B nrPDB Length = 373 Score = 168 bits (425), Expect = 6e-42, Method: Composition-based stats. Identities = 64/324 (19%), Positives = 113/324 (34%), Gaps = 69/324 (21%) Query: 268 ESLRLEVKLGQGCFG---EVWMGTWNGTTR-VAIKTLKPGTMSPE--AFLQ-EAQVMKKL 320 L +G+G F V + + T V ++ + S E FLQ E V K Sbjct: 9 GCYELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLF 67 Query: 321 RHEKLVQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 H +V A +++ +++VT +M+ GS D + + + + + + Y Sbjct: 68 NHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDY 127 Query: 380 VERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFP--------IKW 431 + M YVHR ++A++IL+ + ++ GL + + RQ + W Sbjct: 128 IHHMGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKYSVKVLPW 185 Query: 432 TAPEAALY--GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM----- 484 +PE + KSD++S GI EL G VP+ M ++L + G Sbjct: 186 LSPEVLQQNLQGYDAKSDIYSVGITACELA-NGHVPFKDMPATQMLLEKLNGTVPCLLDT 244 Query: 485 -----------------------------PCPPE-----------CPESLHDLMCQCWRK 504 P P H + QC ++ Sbjct: 245 STIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQR 304 Query: 505 EPEERPTFEYLQAFLEDYFTSTEP 528 P+ RP+ L +F + Sbjct: 305 NPDARPSASTLLN--HSFFKQIKR 326 >6NT9-A nrPDB Length = 742 Score = 167 bits (424), Expect = 8e-42, Method: Composition-based stats. Identities = 58/232 (25%), Positives = 103/232 (44%), Gaps = 24/232 (10%) Query: 272 LEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSP--EAFLQEAQVMKKLRHEKLVQL 328 L LGQG V+ G T + AIK + + ++E +V+KKL H+ +V+L Sbjct: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 70 Query: 329 YAVVSE---EPIYIVTEYMSKGSLLDFLKGETGKY-LRLPQLVDMAAQIASGMAYVERMN 384 +A+ E ++ E+ GSL L+ + Y L + + + + GM ++ Sbjct: 71 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 130 Query: 385 YVHRDLRAANIL--VGENLV--CKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL-- 438 VHR+++ NI+ +GE+ K+ DFG AR +ED+E ++ P+ Sbjct: 131 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE--QFVSLYGTEEYLHPDMYERA 188 Query: 439 ------YGRFTIKSDVWSFGILLTELTTKGRV--PYPG-MVNREVLDQVERG 481 ++ D+WS G+ T P+ G N+EV+ ++ G Sbjct: 189 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 240 >6O8B-A nrPDB Length = 665 Score = 167 bits (423), Expect = 1e-41, Method: Composition-based stats. Identities = 58/232 (25%), Positives = 103/232 (44%), Gaps = 24/232 (10%) Query: 272 LEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSP--EAFLQEAQVMKKLRHEKLVQL 328 L LGQG V+ G T + AIK + + ++E +V+KKL H+ +V+L Sbjct: 19 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKL 78 Query: 329 YAVVSE---EPIYIVTEYMSKGSLLDFLKGETGKY-LRLPQLVDMAAQIASGMAYVERMN 384 +A+ E ++ E+ GSL L+ + Y L + + + + GM ++ Sbjct: 79 FAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMNHLRENG 138 Query: 385 YVHRDLRAANIL--VGENLV--CKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL-- 438 VHR+++ NI+ +GE+ K+ DFG AR +ED+E ++ P+ Sbjct: 139 IVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDE--QFVELYGTEEYLHPDMYERA 196 Query: 439 ------YGRFTIKSDVWSFGILLTELTTKGRV--PYPG-MVNREVLDQVERG 481 ++ D+WS G+ T P+ G N+EV+ ++ G Sbjct: 197 VLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG 248 >4XHH-A nrPDB Length = 403 Score = 167 bits (422), Expect = 2e-41, Method: Composition-based stats. Identities = 59/277 (21%), Positives = 108/277 (38%), Gaps = 19/277 (6%) Query: 268 ESLRLEVKLGQGCFGEVWMGT-WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLV 326 R+ K+G G FG+++ GT VAI+ + P+ E++V K L + Sbjct: 7 RKFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQ-LDYESRVYKYLSGGVGI 65 Query: 327 QLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 E Y G L+ L + ++ +A Q+ + Y+ +++ Sbjct: 66 PFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRKFSFKTVIMLALQMICRVQYIHGRSFI 125 Query: 387 HRDLRAANILVG---ENLVCKVADFGLARLIED------NEYTARQGAKFPIKWTAPEAA 437 HRD++ N L+G V DFGL++ D Y + ++ + Sbjct: 126 HRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTH 185 Query: 438 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGM---VNREVLDQV-ERGYRMPCPPEC--- 490 L + + D+ S G +L KG +P+ G+ ++ D++ E+ + C Sbjct: 186 LGIEQSRRDDLESLGYMLIY-FCKGSLPWQGLKATTKKQKYDRILEKKLCISVETLCAGL 244 Query: 491 PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE 527 P + M C + +ERP + YL +D E Sbjct: 245 PLEFSEYMNYCRNLKFDERPDYLYLARLFKDLSIKLE 281 >5C01-A nrPDB Length = 342 Score = 165 bits (419), Expect = 3e-41, Method: Composition-based stats. Identities = 80/328 (24%), Positives = 130/328 (39%), Gaps = 45/328 (13%) Query: 232 YYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWE-IPRESLRLEVKLGQGCFGEVWMGTWN 290 Y+ + + + P+T L++ ++ + ++ + LGQG V+ G Sbjct: 21 YFQGAMGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLR 80 Query: 291 GTT-------------------------RVAIKTLKPGTMSPEAFLQE-AQVMKKLRHEK 324 RV +K L P E A +M ++ H Sbjct: 81 VEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTH 140 Query: 325 LVQLYAVVSEEPIYI-VTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 L ++ V P I VTEY+ G L +L+ E G ++ + + +A Q+AS ++Y+E Sbjct: 141 LAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERG-HVPMAWKMVVAQQLASALSYLENK 199 Query: 384 NYVHRDLRAANILV-------GENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436 N VH ++ NIL+ G + K++D G+ +R+ I W APE Sbjct: 200 NLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGV-----GLGALSREERVERIPWLAPEC 254 Query: 437 ALYG--RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESL 494 G + D W FG L E+ G P E +R +R+P P CP+ L Sbjct: 255 LPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPS-CPQ-L 312 Query: 495 HDLMCQCWRKEPEERPTFEYLQAFLEDY 522 L QC EP +RP+F + L Sbjct: 313 ATLTSQCLTYEPTQRPSFRTILRDLTRL 340 >5VDK-A nrPDB Length = 297 Score = 165 bits (419), Expect = 3e-41, Method: Composition-based stats. Identities = 63/281 (22%), Positives = 109/281 (38%), Gaps = 41/281 (14%) Query: 267 RESLRLEVKLGQGCFGEVWMGTWNGTTRV-AIKT-LKPGTM--SPEAFLQEAQVMKKL-R 321 + K+G G FG V+ V AIK +K T + + L E L Sbjct: 14 EKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHAVLGH 73 Query: 322 HEKLVQLYAVVSEEPIYIVT-EYMSKGSLLDFLKGET--GKYLRLPQLVDMAAQIASGMA 378 H +V+ Y+ +E+ I+ EY + GSL + T G + P+L D+ QI+ G+ Sbjct: 74 HPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEPKLKDILLQISLGLN 133 Query: 379 YVERMNYVHRDLRAANI-----------------------LVGENLVCKVADFGLARLIE 415 Y+ + VH D++ +NI + N++ K+ D G A I Sbjct: 134 YIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIGDLGHATSIN 193 Query: 416 DNEYTARQGAKFPIKWTAPEAALYG-RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREV 474 + + ++ A E R K+D+++ G+ + +P N Sbjct: 194 -----KPKVEEGDSRFLANEILQEDYRHLPKADIFALGLTIAVAAGAESLP----TNGAA 244 Query: 475 LDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYL 515 + +G P E ES L+ + + E+RP+ L Sbjct: 245 WHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAAL 285 >4I94-A nrPDB Length = 300 Score = 165 bits (418), Expect = 4e-41, Method: Composition-based stats. Identities = 54/242 (22%), Positives = 105/242 (43%), Gaps = 12/242 (4%) Query: 283 EVWMGTWNGTTRVAIKTLKPGTM-SPEAFLQEAQVMKKLRHEKLVQLYAVV-SEEPIYIV 340 V+ G R+A+K + FL+EA+ + +LR+ ++ L +E ++ Sbjct: 44 VVYKGKLENQRRIAVKRFNRKSWPDSRQFLEEAKAVGQLRNHRMANLLGCCYEDEERLLI 103 Query: 341 TEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN-YVHRDLRAANILVGE 399 E+M +L L + ++ + +A IA + Y ++ DL A +L + Sbjct: 104 AEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHDLNAYRVLFDD 163 Query: 400 NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELT 459 + +++ FGL + D + + + +T PE GR T +S ++SFG LL +L Sbjct: 164 DANPRLSCFGLMKNSRDGKSYS-----TNLAFTPPEYLRTGRVTPESVIYSFGTLLLDLL 218 Query: 460 TKGRVP----YPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYL 515 + +P + +R + ++ G + L L +C + EP ERP + L Sbjct: 219 SGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSSDDGTELIRLASRCLQYEPRERPNPKSL 278 Query: 516 QA 517 + Sbjct: 279 VS 280 >3SOC-A nrPDB Length = 322 Score = 165 bits (418), Expect = 4e-41, Method: Composition-based stats. Identities = 61/287 (21%), Positives = 115/287 (40%), Gaps = 50/287 (17%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK--KLRHEKLVQ 327 L+L +G FG VW VA+K +++ E +V ++HE ++Q Sbjct: 26 LQLLEVKARGRFGCVWKAQL-LNEYVAVKIFPI--QDKQSWQNEYEVYSLPGMKHENILQ 82 Query: 328 LYAVVSEE-----PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE- 381 ++++T + KGSL DFLK + +L +A +A G+AY+ Sbjct: 83 FIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKAN---VVSWNELCHIAETMARGLAYLHE 139 Query: 382 ---------RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ-GAKFPIKW 431 + HRD+++ N+L+ NL +ADFGLA E + G ++ Sbjct: 140 DIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRY 199 Query: 432 TAPEAAL-----YGRFTIKSDVWSFGILLTELTTKG----------RVPYPGM-----VN 471 APE ++ D+++ G++L EL ++ +P+ Sbjct: 200 MAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSL 259 Query: 472 REVLDQVERGYRMPCPPECPES------LHDLMCQCWRKEPEERPTF 512 ++ + V + P + + L + + +CW + E R + Sbjct: 260 EDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSA 306 >4BTK-A nrPDB Length = 337 Score = 165 bits (417), Expect = 5e-41, Method: Composition-based stats. Identities = 57/303 (18%), Positives = 116/303 (38%), Gaps = 15/303 (4%) Query: 232 YYSKHADG-LCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWN 290 Y+ +A L L S Q A + ++ ++ K+G G FGE++ Sbjct: 19 YFQSNAMQCLAAALKDETNMSGGGEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDL 78 Query: 291 GTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRH-EKLVQLYAVVSEEPIYIVTEYMSKGS 348 T VA+K ++ + E V+KKL+ + + + E V + + Sbjct: 79 LTRENVALK-VESAQQPKQVLKMEVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRN 137 Query: 349 LLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANI----LVGENLVCK 404 L D + + L + + QI + + + ++HRD++ +N L C Sbjct: 138 LADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCY 197 Query: 405 VADFGLARLIEDNEYTAR-----QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELT 459 + DFGLAR + R G + +++ + A D+WS +L E Sbjct: 198 MLDFGLARQYTNTTGDVRPPRNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFA 257 Query: 460 TKGRVPYPGMVNREVLDQVERGYRMP-CPPECPESLHDLMCQCWRKEPEERPTFEYLQAF 518 G++P+ + ++E + ++ Y P H + + +P ++ + + Sbjct: 258 V-GQLPWRKIKDKEQVGMIKEKYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSV 316 Query: 519 LED 521 E+ Sbjct: 317 FEN 319 >4NFN-A nrPDB Length = 309 Score = 164 bits (415), Expect = 8e-41, Method: Composition-based stats. Identities = 52/280 (18%), Positives = 109/280 (38%), Gaps = 14/280 (5%) Query: 254 QTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQ 312 Q A + ++ ++ K+G G FGE++ T VA+K ++ + Sbjct: 7 GEQADILPANYVVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-VESAQQPKQVLKM 65 Query: 313 EAQVMKKLRH-EKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA 371 E V+KKL+ + + + E V + +L D + + L + + Sbjct: 66 EVAVLKKLQGKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGK 125 Query: 372 QIASGMAYVERMNYVHRDLRAANI----LVGENLVCKVADFGLARLIEDNEYTAR----- 422 QI + + + ++HRD++ +N L C + DFGLAR + R Sbjct: 126 QILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNV 185 Query: 423 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGY 482 G + +++ + A D+WS +L E G++P+ + ++E + ++ Y Sbjct: 186 AGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAV-GQLPWRKIKDKEQVGMIKEKY 244 Query: 483 RMP-CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLED 521 P H + + +P ++ + + E+ Sbjct: 245 EHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFEN 284 >4CRL-A nrPDB Length = 406 Score = 164 bits (414), Expect = 1e-40, Method: Composition-based stats. Identities = 64/322 (19%), Positives = 113/322 (35%), Gaps = 72/322 (22%) Query: 275 KLGQGCFGEVWMGTWNGTTR---VAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAV 331 K+G+G +G V+ A+K + GT + +E ++++L+H ++ L V Sbjct: 29 KVGRGTYGHVYKAKRKDGKDDKDYALKQI-EGTGISMSACREIALLRELKHPNVISLQKV 87 Query: 332 V---SEEPIYIVTEYMSKGSLLDFLK-------GETGKYLRLPQLVDMAAQIASGMAYVE 381 ++ ++++ +Y L +K + L + + QI G+ Y+ Sbjct: 88 FLSHADRKVWLLFDYAEH-DLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLH 146 Query: 382 RMNYVHRDLRAANILVG----ENLVCKVADFGLARLIED--NEYTARQGAKFPIKWTAPE 435 +HRDL+ ANILV E K+AD G ARL + APE Sbjct: 147 ANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPE 206 Query: 436 AALY-GRFTIKSDVWSFGILLTELTTKGRVPYP---------GMVNREVLDQVERGYRMP 485 L +T D+W+ G + EL T + + + LD++ P Sbjct: 207 LLLGARHYTKAIDIWAIGCIFAELLTS-EPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFP 265 Query: 486 CPPEC------PES-------------------------------LHDLMCQCWRKEPEE 508 + PE L+ + +P + Sbjct: 266 ADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIK 325 Query: 509 RPTFEYLQA---FLEDYFTSTE 527 R T E FLED +++ Sbjct: 326 RITSEQAMQDPYFLEDPLPTSD 347 >4WOV-A nrPDB Length = 317 Score = 163 bits (413), Expect = 2e-40, Method: Composition-based stats. Identities = 76/295 (25%), Positives = 117/295 (39%), Gaps = 44/295 (14%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTT-------------------------RVAIK 298 + ++ + LGQG V+ G RV +K Sbjct: 31 RVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLK 90 Query: 299 TLKPGTMSPEAFLQE-AQVMKKLRHEKLVQLYAVVSEEPIYI-VTEYMSKGSLLDFLKGE 356 L P E A +M ++ H L ++ V P I VTEY+ G L +L+ E Sbjct: 91 VLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRE 150 Query: 357 TGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILV-------GENLVCKVADFG 409 G ++ + + +A Q+AS ++Y+E N VH ++ NIL+ G + K++D G Sbjct: 151 RG-HVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPG 209 Query: 410 LARLIEDNEYTARQGAKFPIKWTAPEAALYG--RFTIKSDVWSFGILLTELTTKGRVPYP 467 + +R+ I W APE G + D W FG L E+ G P Sbjct: 210 V-----GLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQ 264 Query: 468 GMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDY 522 E +R +R+P P CP+ L L QC EP +RP+F + L Sbjct: 265 SRSPSEKEHFYQRQHRLPEPS-CPQ-LATLTSQCLTYEPTQRPSFRTILRDLTRL 317 >2QLU-A nrPDB Length = 314 Score = 161 bits (408), Expect = 6e-40, Method: Composition-based stats. Identities = 64/293 (21%), Positives = 121/293 (41%), Gaps = 51/293 (17%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKK--LRH 322 +PR SL+L +G FG VW VA+K +++ E ++ ++H Sbjct: 12 VPRGSLQLLEIKARGRFGCVWKAQL-MNDFVAVKIFPL--QDKQSWQSEREIFSTPGMKH 68 Query: 323 EKLVQLYAVVSEE-----PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 E L+Q A ++++T + KGSL D+LK G + +L +A ++ G+ Sbjct: 69 ENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLK---GNIITWNELCHVAETMSRGL 125 Query: 378 AYVE-----------RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQ-GA 425 +Y+ + + HRD ++ N+L+ +L +ADFGLA E + G Sbjct: 126 SYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQ 185 Query: 426 KFPIKWTAPEAAL-----YGRFTIKSDVWSFGILLTELTTKGR----------VPYPGM- 469 ++ APE ++ D+++ G++L EL ++ + +P+ Sbjct: 186 VGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEI 245 Query: 470 ----VNREVLDQVE-RGYRMPCPPECPES--LHDL---MCQCWRKEPEERPTF 512 E+ + V + R + L L + +CW + E R + Sbjct: 246 GQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSA 298 >5J0A-A nrPDB Length = 300 Score = 160 bits (404), Expect = 2e-39, Method: Composition-based stats. Identities = 57/289 (19%), Positives = 117/289 (40%), Gaps = 43/289 (14%) Query: 272 LEVKLGQGCFGE---VWMGTWNGTTRV----AIKTLKP------GTMSPEAFLQEAQVMK 318 KLG FG V++ + A+K + P ++ + + EA+++K Sbjct: 13 FMQKLG---FGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILK 69 Query: 319 KLRHEKLVQLYAVVS--EEPIYIVTEYMSKGSLLDFLKGE---TGKYLRLPQLVDMAAQI 373 L H +V A + + + EY + SL D ++ + ++ +A + Sbjct: 70 SLHHPNIVGYRAFTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNM 129 Query: 374 ASGMAYVE-RMNYVHRDLRAANILVGENL-VCKVADFGLARLIEDN-EYTARQGAK-FPI 429 A G+ Y+ +H D++++N+++ + K+ D G++ +++N E T + Sbjct: 130 ARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTE 189 Query: 430 KWTAPEAA-LYGRFTIKSDVWSFGILLTELTTKGRVP-------------YPGMVNREVL 475 W EA G T K+D+++FG+ L E+ T + + Sbjct: 190 PWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEA 249 Query: 476 DQVERGYRMPCP----PECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 520 G R P E + + +L C ++P++RP+ ++ LE Sbjct: 250 YYAALGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEALE 298 >4XHL-A nrPDB Length = 394 Score = 158 bits (401), Expect = 4e-39, Method: Composition-based stats. Identities = 56/277 (20%), Positives = 108/277 (38%), Gaps = 19/277 (6%) Query: 268 ESLRLEVKLGQGCFGEVWMGT-WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLV 326 R+ K+G G FG+++ GT VAI+ + P+ E++V + L + Sbjct: 7 RKFRIGRKIGSGSFGDIYHGTNLISGEEVAIRLESIRSRHPQ-LDYESRVYRYLSGGVGI 65 Query: 327 QLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 E Y G L+ L + ++ +A Q+ + Y+ +++ Sbjct: 66 PFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLALQMFCRIQYIHGRSFI 125 Query: 387 HRDLRAANILVG---ENLVCKVADFGLARLIED------NEYTARQGAKFPIKWTAPEAA 437 HRD++ N L+G V DFGL++ D Y + ++ + Sbjct: 126 HRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGTARYASVNTH 185 Query: 438 LYGRFTIKSDVWSFGILLTELTTKGRVPYPGM---VNREVLDQV-ERGYRMPCPPEC--- 490 L + + D+ S G +L KG +P+ G+ ++ D++ E+ + C Sbjct: 186 LGIEQSRRDDLESLGYVLIY-FCKGSLPWQGLKATTKKQKYDRIMEKKLNVSVETLCSGL 244 Query: 491 PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE 527 P + M C + +E+P + +L +D E Sbjct: 245 PLEFQEYMAYCKNLKFDEKPDYLFLARLFKDLSIKLE 281 >2CMW-A nrPDB Length = 310 Score = 156 bits (394), Expect = 3e-38, Method: Composition-based stats. Identities = 70/279 (25%), Positives = 118/279 (42%), Gaps = 26/279 (9%) Query: 269 SLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRH--EKL 325 S+R+ K+G G FGE+ +G T VAIK + +P+ L E + K+L E L Sbjct: 1 SMRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHL-EYRFYKQLGSAGEGL 59 Query: 326 VQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN 384 Q+Y +V E + G L+ L + L ++ +A Q+ S M YV N Sbjct: 60 PQVYYFGPCGKYNAMVLELL--GPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKN 117 Query: 385 YVHRDLRAANILVGENLVCK-----VADFGLARLIEDNE------YTARQGAKFPIKWTA 433 ++RD++ N L+G K + DFGLA+ D E Y + ++ + Sbjct: 118 LIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMS 177 Query: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM---VNREVLDQVERGYR-MPCPPE 489 L + + D+ + G + +G +P+ G+ +E ++ R P Sbjct: 178 INTHLGKEQSRRDDLEALGHMFMYFL-RGSLPWQGLKADTLKERYQKIGDTKRNTPIEAL 236 Query: 490 C---PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTS 525 C PE + + R + E+P +EYL+ D F Sbjct: 237 CENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEK 275 >3LLT-A nrPDB Length = 360 Score = 155 bits (391), Expect = 6e-38, Method: Composition-based stats. Identities = 51/252 (20%), Positives = 100/252 (39%), Gaps = 39/252 (15%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTRV-AIKTLKPGTMSPEAFLQEAQVMKKLRHEKL--- 325 + K+G G FG V + + A+K ++ + EA ++KK++++ + Sbjct: 37 FLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQNDDINNN 96 Query: 326 --VQLYA-VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 V+ + + + + ++ E + SL + + + + +I + Y+ + Sbjct: 97 NIVKYHGKFMYYDHMCLIFEPL-GPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLRK 155 Query: 383 MNYVHRDLRAANILVGE-------------------------NLVCKVADFGLARLIEDN 417 M+ H DL+ NIL+ + + K+ DFG A D Sbjct: 156 MSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKSDY 215 Query: 418 EYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQ 477 + ++ APE L + + SD+WSFG +L EL T G + + + E L Sbjct: 216 HGSIIN----TRQYRAPEVILNLGWDVSSDMWSFGCVLAELYT-GSLLFRTHEHMEHLAM 270 Query: 478 VERGYRMPCPPE 489 +E + P P Sbjct: 271 MESIIQ-PIPKN 281 >1GRI-A nrPDB Length = 217 Score = 153 bits (388), Expect = 1e-37, Method: Composition-based stats. Identities = 51/151 (33%), Positives = 84/151 (55%), Gaps = 12/151 (7%) Query: 87 TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSI 146 +A YD+++ + +LSFK+G+ L+++N W L G+ G+IP NY+ + Sbjct: 1 MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAEL-NGKDGFIPKNYIE----M 55 Query: 147 QAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYK 206 + W+FGKI R ++E +L + G FL+RESE+ G + LSV G +V+H+K Sbjct: 56 KPHPWFFGKIPRAKAEEMLSKQRH-DGAFLIRESESAPGDFSLSVK-----FGNDVQHFK 109 Query: 207 IRKLDSGGFYITSRTQFNSLQQLVAYYSKHA 237 + + D G Y +FNSL +LV Y+ + Sbjct: 110 VLR-DGAGKYFLWVVKFNSLNELVDYHRSTS 139 Score = 75.4 bits (184), Expect = 6e-14, Method: Composition-based stats. Identities = 19/63 (30%), Positives = 37/63 (58%), Gaps = 2/63 (3%) Query: 82 LAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVA 141 + T AL+D++ + + +L F++G+ + +++N++ +WW GQTG P NYV Sbjct: 154 VPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGA--CHGQTGMFPRNYVT 211 Query: 142 PSD 144 P + Sbjct: 212 PVN 214 >2C47-A nrPDB Length = 313 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 63/276 (22%), Positives = 114/276 (41%), Gaps = 25/276 (9%) Query: 269 SLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRH-EKLV 326 + R+ K+G G FGE+ +G T VAIK + +P+ L E + K+L E + Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHL-EYRFYKQLSATEGVP 63 Query: 327 QLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNY 385 Q+Y +V E + G L+ L + L ++ +A Q+ + M YV + Sbjct: 64 QVYYFGPCGKYNAMVLELL--GPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSL 121 Query: 386 VHRDLRAANILVGENLV-----CKVADFGLARLIEDNE------YTARQGAKFPIKWTAP 434 ++RD++ N LVG + DFGLA+ D E Y + ++ + Sbjct: 122 IYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSI 181 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM---VNREVLDQVERGYRMPCP---- 487 L + + D+ + G + +G +P+ G+ +E ++ R Sbjct: 182 NTHLGKEQSRRDDLEALGHMFMYFL-RGSLPWQGLKADTLKERYQKIGDTKRATPIEVLC 240 Query: 488 PECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 PE + + R + E+P ++YL+ D F Sbjct: 241 ENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLF 276 >4NT4-A nrPDB Length = 312 Score = 152 bits (384), Expect = 4e-37, Method: Composition-based stats. Identities = 58/282 (20%), Positives = 113/282 (40%), Gaps = 31/282 (10%) Query: 269 SLRLEVKLGQGCFGEVWMGT-WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKL-RH---- 322 + R+ K+G G FGE+ +G VAIK + +P+ L E + K L H Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKMEPMKSKAPQLHL-EYRFYKLLGSHADNA 71 Query: 323 -EKLVQLY--AVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAY 379 + + ++Y +V E + G L+ L + L ++ +A Q+ + Y Sbjct: 72 PDGIPRIYHLGTCGGRYNAMVLELL--GLSLEDLFNICARKFSLKTVLMIAKQLLHRIEY 129 Query: 380 VERMNYVHRDLRAANILVGENLV-----CKVADFGLARLIEDNE------YTARQGAKFP 428 V + ++RD++ N L+G + DFGLA+ D + Y + Sbjct: 130 VHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYREHKSLTGT 189 Query: 429 IKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM---VNREVLDQVERGYR-M 484 ++ + + + + D+ + G + +G +P+ G+ +E ++ R Sbjct: 190 ARYMSINTHMGREQSRRDDLEALGHMFMYFL-RGSLPWQGLKADTLKERYQKIGDTKRAT 248 Query: 485 PCPPEC---PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 P C PE + R + E P +++L+ +D F Sbjct: 249 PIEVLCDGHPEEFATYLRYVRRLDFFETPDYDFLRRLFQDLF 290 >2CHL-A nrPDB Length = 351 Score = 151 bits (381), Expect = 9e-37, Method: Composition-based stats. Identities = 61/290 (21%), Positives = 111/290 (38%), Gaps = 22/290 (7%) Query: 254 QTQGLAKDAWEIPRE--SLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAF 310 T+ L + + + R+ K+G G FGE+ +G T VAIK + +P+ Sbjct: 14 GTENLYFQSMGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLH 73 Query: 311 LQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMA 370 L E + K+L + Y G L+ L + L ++ +A Sbjct: 74 L-EYRFYKQLGSGDGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIA 132 Query: 371 AQIASGMAYVERMNYVHRDLRAANILVGENLV-----CKVADFGLARLIEDNE------Y 419 Q+ S M YV N ++RD++ N L+G + DF LA+ D E Y Sbjct: 133 IQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPY 192 Query: 420 TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM---VNREVLD 476 + ++ + L + + D+ + G + +G +P+ G+ +E Sbjct: 193 REHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFL-RGSLPWQGLKADTLKERYQ 251 Query: 477 QVERGYR-MPCPPECP--ESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 ++ R P C + + R + E+P ++YL+ D F Sbjct: 252 KIGDTKRATPIEVLCENFPEMATYLRYVRRLDFFEKPDYDYLRKLFTDLF 301 >2JD5-A nrPDB Length = 373 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 62/331 (18%), Positives = 121/331 (36%), Gaps = 77/331 (23%) Query: 269 SLRLEVKLGQGCFGEVWMGTW-NGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHE---- 323 L KLG G F VW+ T VA+K ++ + EA E ++++++ Sbjct: 20 RYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTK 79 Query: 324 -------KLVQLYAVVSEE-----PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA 371 +++L + + + +V E + +LL +K + + L + ++ Sbjct: 80 EDSMGANHILKLLDHFNHKGPNGVHVVMVFE-VLGENLLALIKKYEHRGIPLIYVKQISK 138 Query: 372 QIASGMAYVERM-NYVHRDLRAANILVG-----ENL-VCKVADFGLARLIEDNEYTARQG 424 Q+ G+ Y+ R +H D++ N+L+ ENL K+AD G A +++ + Q Sbjct: 139 QLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHYTNSIQ- 197 Query: 425 AKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTK----------------------- 461 ++ +PE L + +D+WS L+ EL T Sbjct: 198 ---TREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDHIAQII 254 Query: 462 ---GRVPYPGMVNRE----------VLDQVERGYRMPCPPECPE----------SLHDLM 498 G +P + N + +L + + P E + D + Sbjct: 255 ELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDFL 314 Query: 499 CQCWRKEPEERPTFEYL--QAFLEDYFTSTE 527 + +P +R L +L+D E Sbjct: 315 SPMLQLDPRKRADAGGLVNHPWLKDTLGMEE 345 >2PVN-A nrPDB Length = 352 Score = 147 bits (372), Expect = 1e-35, Method: Composition-based stats. Identities = 47/300 (15%), Positives = 102/300 (34%), Gaps = 52/300 (17%) Query: 266 PRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKL 325 ++ + K+G+G + EV+ G I + + + + + Sbjct: 50 EQDDYEVVRKVGRGKYSEVFEGINVNNNEKCIIKILKPVKKKKIKREIKILQNLCGGPNI 109 Query: 326 VQLYAVVSEEP---IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 V+L +V ++ ++ EY++ L + ++ + Y Sbjct: 110 VKLLDIVRDQHSKTPSLIFEYVNNTD-----FKVLYPTLTDYDIRYYIYELLKALDYCHS 164 Query: 383 MNYVHRDLRAANILVGENL-VCKVADFGLARLIEDN-EYTARQGAKFPIKWTAPEAALY- 439 +HRD++ N+++ L ++ D+GLA EY R +++ + PE + Sbjct: 165 QGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRY---FKGPELLVDL 221 Query: 440 GRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER------------GYRMPCP 487 + D+WS G + + + + G N + L ++ + YR+ Sbjct: 222 QDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKYRIELD 281 Query: 488 PE------------------------CPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 P+ D + + R + +ER T L+A YF Sbjct: 282 PQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTA--LEAMTHPYF 339 >2PMN-X nrPDB Length = 348 Score = 147 bits (372), Expect = 1e-35, Method: Composition-based stats. Identities = 59/307 (19%), Positives = 116/307 (37%), Gaps = 54/307 (17%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEA------------------ 309 R+ L QG F ++ + A+K + + + Sbjct: 31 NDYRIIRTLNQGKFNKIILCE-KDNKFYALKKYEKSLLEKKRDFTKSNNDKISIKSKYDD 89 Query: 310 FLQEAQVMKKLRHEKLVQLYAVVSE-EPIYIVTEYMSKGSLLDF------LKGETGKYLR 362 F E Q++ +++E + +++ + +YI+ EYM S+L F L ++ Sbjct: 90 FKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTCFIP 149 Query: 363 LPQLVDMAAQIASGMAYVE-RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA 421 + + + + + +Y+ N HRD++ +NIL+ +N K++DFG + + D + Sbjct: 150 IQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGESEYMVDKKIK- 208 Query: 422 RQGAKFPIKWTAPEAALYG-RF-TIKSDVWSFGILLTELTTKGRVPYP-GMVNREVLDQV 478 G++ ++ PE + K D+WS GI L + VP+ + E+ + + Sbjct: 209 --GSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYN-VVPFSLKISLVELFNNI 265 Query: 479 E-RGYRMPCPPE------------CPESL-----HDLMCQCWRKEPEERPTFEYLQAFLE 520 + P C + D + RK P ER T E A Sbjct: 266 RTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERITSED--ALKH 323 Query: 521 DYFTSTE 527 ++ T Sbjct: 324 EWLADTN 330 >6HMD-A nrPDB Length = 365 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 52/343 (15%), Positives = 116/343 (33%), Gaps = 69/343 (20%) Query: 243 RLTTVCPTSKPQTQGLAKDAWEIP----RESLRLEVKLGQGCFGEVWMGTWNGTTRVAIK 298 R + +++ +P ++ +L KLG+G + EV+ Sbjct: 24 RARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNE---- 79 Query: 299 TLKPGTMSPEAFLQEAQV-----MKKLRHE-KLVQLYAVVSE---EPIYIVTEYMSKGSL 349 + + ++ ++ LR +++L V + + +V EY++ Sbjct: 80 --RVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTD- 136 Query: 350 LDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADF 408 + + L + ++ + Y +HRD++ N+++ + ++ D+ Sbjct: 137 ----FKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDW 192 Query: 409 GLARLIEDN-EYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPY 466 GLA EY R +++ + PE + Y + D+WS G +L + + + Sbjct: 193 GLAEFYHPAQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFF 249 Query: 467 PGMVNREVLDQV------------ERGYRMPCPPEC------------------------ 490 G N + L ++ + Y + P Sbjct: 250 HGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLV 309 Query: 491 PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTS-TEPQYQP 532 DL+ + R + ++R T + YF + Q QP Sbjct: 310 SPEALDLLDKLLRYDHQQRLTAKEAME--HPYFYPVVKEQSQP 350 >4L68-A nrPDB Length = 340 Score = 145 bits (365), Expect = 5e-35, Method: Composition-based stats. Identities = 57/251 (22%), Positives = 103/251 (41%), Gaps = 21/251 (8%) Query: 282 GEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS-EEPIYIV 340 G + + +A+K L + F E + +LRH L L EE ++V Sbjct: 54 GTTYKALLPDGSALAVKHLSTCKLGEREFRYEMNQLWELRHSNLAPLLGFCVVEEEKFLV 113 Query: 341 TEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER---MNYVHRDLRAANILV 397 +YMS G+L L G+ L + A G+A++ +H+++ ++ IL+ Sbjct: 114 YKYMSNGTLHSLLDSNRGE-LDWSTRFRIGLGAARGLAWLHHGCRPPILHQNICSSVILI 172 Query: 398 GENLVCKVADFGLARLI---EDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGIL 454 E+ ++ D GLARL+ ++NE + G + APE + ++K DV+ G++ Sbjct: 173 DEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTMLASLKGDVYGLGVV 232 Query: 455 LTELTTK----GRVPYPG---------MVNREVLDQVERGYRMPCPPECPESLHDLMCQC 501 L EL T G + G + + + + R E ++ C Sbjct: 233 LLELATGLKAVGGEGFKGSLVDWVKQLESSGRIAETFDENIRGKGHDEEISKFVEIALNC 292 Query: 502 WRKEPEERPTF 512 P+ER + Sbjct: 293 VSSRPKERWSM 303 >3QD2-B nrPDB Length = 332 Score = 144 bits (364), Expect = 8e-35, Method: Composition-based stats. Identities = 58/334 (17%), Positives = 108/334 (32%), Gaps = 86/334 (25%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWN-GTTRVAI-------------KTLKPG---------- 303 +G+G FG V+ AI K ++ Sbjct: 6 TDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPG 65 Query: 304 ---------TMSPEAFLQEA-QV-MKK------LRHE--------KLVQLYAVVSEEP-- 336 PE + +E ++ +K L K+ ++ ++ Sbjct: 66 IVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFSTKNTVG 125 Query: 337 ----------IYIVTEYMSKGSLLDFLKGETGKYLRLPQL-VDMAAQIASGMAYVERMNY 385 +YI + K +L D++ R + + + QIA + ++ Sbjct: 126 QLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGL 185 Query: 386 VHRDLRAANILVGENLVCKVADFGLARLIEDNE-----------YTARQGAKFPIKWTAP 434 +HRDL+ +NI + V KV DFGL ++ +E Y G + +P Sbjct: 186 MHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSP 245 Query: 435 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP----PEC 490 E ++ K D++S G++L EL Y E + + + P + Sbjct: 246 EQIHGNNYSHKVDIFSLGLILFELL------YSFSTQMERVRIITDVRNLKFPLLFTQKY 299 Query: 491 PESLHDLMCQCWRKEPEERPTFEYLQA--FLEDY 522 P+ H ++ P ERP + E+ Sbjct: 300 PQE-HMMVQDMLSPSPTERPEATDIIENAIFENL 332 >5X1R-A nrPDB Length = 302 Score = 144 bits (363), Expect = 9e-35, Method: Composition-based stats. Identities = 58/286 (20%), Positives = 116/286 (40%), Gaps = 43/286 (15%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPE------------------ 308 ++ +G+G FG V+ + R +AIK P +++ Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 309 ----AFLQEAQVMKKLRHEKLVQLYAVVSEEP-IYIVTEYMSKGSLLDFLKGETGKYLRL 363 +F+QEA+++ + H L+ + E Y+ T++ S +L + L+ + + + Sbjct: 81 AGLNSFIQEARLLARFSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKN-LQAQQPEKIDE 139 Query: 364 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR-----LIEDNE 418 + + + S + + + Y+HRD+ NI + E+ + + DFG AR L ++ E Sbjct: 140 AWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLSDETE 199 Query: 419 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 + G ++T G +T D+++ G +L L P V+ + Sbjct: 200 IVLKPGFAPIEQYTENSDGEQGPWT---DIYALGAVLHTLIVGSPPP------VSVVRSI 250 Query: 479 ERGYRM---PCPPECPESLHDLMCQCWRKEPEERP-TFEYLQAFLE 520 E Y+ P L + + +PE+RP T + + LE Sbjct: 251 EDSYQPLTERRPAGYSPELLRTVDRALALKPEDRPQTIDEMAELLE 296 >4MD7-E nrPDB Length = 391 Score = 142 bits (359), Expect = 3e-34, Method: Composition-based stats. Identities = 55/330 (16%), Positives = 117/330 (35%), Gaps = 58/330 (17%) Query: 243 RLTTVCPTSKPQTQGLAKDA---WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKT 299 R+ T T +P+ + W ++ +L KLG+G + EV+ + Sbjct: 10 RVYTDVNTHRPREYWDYESHVVEWG-NQDDYQLVRKLGRGKYSEVFEAINITNNEKVV-V 67 Query: 300 LKPGTMSPEAFLQEAQVMKKLRH-EKLVQLYAVVSE---EPIYIVTEYMSKGSLLDFLKG 355 + + +E ++++ LR ++ L +V + +V E+++ Sbjct: 68 KILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-----FK 122 Query: 356 ETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLI 414 + + L + +I + Y M +HRD++ N+++ E+ ++ D+GLA Sbjct: 123 QLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY 182 Query: 415 EDN-EYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR 472 EY R +++ + PE + Y + D+WS G +L + + + G N Sbjct: 183 HPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY 239 Query: 473 EVLDQVER------------GYRMPCPPEC------------------------PESLHD 496 + L ++ + Y + P D Sbjct: 240 DQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD 299 Query: 497 LMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 + + R + + R T A YF + Sbjct: 300 FLDKLLRYDHQSRLTARE--AMEHPYFYTV 327 >5X18-A nrPDB Length = 295 Score = 142 bits (359), Expect = 3e-34, Method: Composition-based stats. Identities = 54/290 (18%), Positives = 112/290 (38%), Gaps = 25/290 (8%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGT-WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRH 322 I ++ K+G+G FG ++ GT VAIK T +P+ E + K L Sbjct: 3 TIVGLHYKIGKKIGEGSFGVLFEGTNMINGVPVAIKFEPRKTEAPQ-LRDEYKTYKILNG 61 Query: 323 EKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVER 382 + +E ++ + G L+ L G+ + +V +A Q+ + + + Sbjct: 62 TPNIPYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAVQMITLIEDLHA 121 Query: 383 MNYVHRDLRAANILVGENL-----VCKVADFGLARLIEDNE------YTARQGAKFPIKW 431 + ++RD++ N L+G + DFG+A+ D + Y ++ ++ Sbjct: 122 HDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLSGTARY 181 Query: 432 TAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM---VNREVLDQVERGYR----M 484 + L + + D+ + G + +G +P+ G+ N++ +++ R Sbjct: 182 MSINTHLGREQSRRDDMEALGHVFFYFL-RGHLPWQGLKAPNNKQKYEKIGEKKRSTNVY 240 Query: 485 PCPPECPESLHDLMCQCWRKEPEERPTFE----YLQAFLEDYFTSTEPQY 530 P + EE P +E L + L+D + + QY Sbjct: 241 DLAQGLPVQFGRYLEIVRSLSFEECPDYEGYRKLLLSVLDDLGETADGQY 290 >4LFI-A nrPDB Length = 374 Score = 141 bits (355), Expect = 8e-34, Method: Composition-based stats. Identities = 65/374 (17%), Positives = 127/374 (33%), Gaps = 97/374 (25%) Query: 243 RLTTVCPTSKPQTQGLAKD---AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKT 299 R+ T + + ++ W + +E K+G+G + EV+ G ++V I Sbjct: 12 RVYTNINKQRTEEYWDYENTVIDWSTNTKDYEIENKVGRGKYSEVFQGV-KLDSKVKIVI 70 Query: 300 --------------------LKPGTMSPEAF----------LQEAQVMKKLR-------- 321 L + P +E V+K +R Sbjct: 71 KMLKPVKKKKIKREIKILTDLSNEKVPPTTLPFQKDQYYTNQKE-DVLKFIRPYIFDQPH 129 Query: 322 --HEKLVQLYAVVSE---EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 H ++ L+ ++ + + +V EY+ L ++ ++ Sbjct: 130 NGHANIIHLFDIIKDPISKTPALVFEYVDNVD-----FRILYPKLTDLEIRFYMFELLKA 184 Query: 377 MAYVERMNYVHRDLRAANILVGE-NLVCKVADFGLARLIEDN-EYTARQGAKFPIKWTAP 434 + Y M +HRD++ N+++ N ++ D+GLA N EY R ++F + P Sbjct: 185 LDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRF---FKGP 241 Query: 435 EAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER------------G 481 E + Y + D+WSFG +L + K + G N + L ++ + Sbjct: 242 ELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLK 301 Query: 482 YRMPCPPEC------------------------PESLHDLMCQCWRKEPEERPTFEYLQA 517 Y + P E + + DL+ R + +ER T + A Sbjct: 302 YEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKE--A 359 Query: 518 FLEDYFTSTEPQYQ 531 +F Q + Sbjct: 360 MGHPWFAPIREQIE 373 >5XVU-A nrPDB Length = 332 Score = 141 bits (355), Expect = 9e-34, Method: Composition-based stats. Identities = 53/341 (15%), Positives = 111/341 (32%), Gaps = 63/341 (18%) Query: 234 SKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT 293 +AD H+ + Q + +EI K+G+G + EV+ G Sbjct: 4 KFYADVNIHKPKEYYDYDNLELQWNKPNRYEIM-------KKIGRGKYSEVFNGYDTECN 56 Query: 294 R-VAIKTLKPGTMSPEAFLQEAQVMKKLRH-EKLVQLYAVVSE---EPIYIVTEYMSKGS 348 R A + + +E ++++ L +++L +V + + ++ EY++ Sbjct: 57 RPCA--IKVLKPVKKKKIKREIKILQNLNGGPNIIKLLDIVKDPVTKTPSLIFEYINN-- 112 Query: 349 LLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVAD 407 + QI + Y +HRD++ NI++ EN ++ Sbjct: 113 ---IDFKTLYPKFTDKDIRYYIYQILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLIS 169 Query: 408 FGLARLIEDN-EYTARQGAKFPIKWTAPEAALY-GRFTIKSDVWSFGILLTELTTKGRVP 465 +GLA EY R +++ + PE + + D+WS G +L + K Sbjct: 170 WGLAEFYHPGQEYNVRVASRY---YKGPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPF 226 Query: 466 YPGMVNREVLDQVER---------------------------GYRMPCPPEC-------- 490 + G N + L ++ + Y Sbjct: 227 FCGHDNYDQLVKIAKVLGTEDLHAYLKKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDI 286 Query: 491 -PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 + + DL+ + + +R + YF + Sbjct: 287 AKDEVIDLIDKMLIYDHAKRIAPKEAME--HPYFREVREES 325 >1CSN-A nrPDB Length = 298 Score = 141 bits (355), Expect = 9e-34, Method: Composition-based stats. Identities = 51/278 (18%), Positives = 106/278 (38%), Gaps = 21/278 (7%) Query: 269 SLRLEVKLGQGCFGEVWMGT-WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQ 327 ++ ++G+G FG ++ GT +VAIK + +P+ E + K L + Sbjct: 11 HYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKFEPRRSDAPQ-LRDEYRTYKLLAGCTGIP 69 Query: 328 LYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 +E ++ V G L+ L G+ + + A Q+ + + + + V+ Sbjct: 70 NVYYFGQEGLHNVLVIDLLGPSLEDLLDLCGRKFSVKTVAMAAKQMLARVQSIHEKSLVY 129 Query: 388 RDLRAANILVGENLV-----CKVADFGLARLIED------NEYTARQGAKFPIKWTAPEA 436 RD++ N L+G V DFG+ + D Y ++ ++ + Sbjct: 130 RDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGTARYMSINT 189 Query: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGM---VNREVLDQV-ERGYRMPCPPEC-- 490 L + + D+ + G + +G +P+ G+ N++ +++ E+ P C Sbjct: 190 HLGREQSRRDDLEALGHVFMYFL-RGSLPWQGLKAATNKQKYERIGEKKQSTPLRELCAG 248 Query: 491 -PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE 527 PE + M + P ++YLQ Sbjct: 249 FPEEFYKYMHYARNLAFDATPDYDYLQGLFSKVLERLN 286 >6EII-A nrPDB Length = 352 Score = 140 bits (353), Expect = 1e-33, Method: Composition-based stats. Identities = 55/330 (16%), Positives = 116/330 (35%), Gaps = 58/330 (17%) Query: 243 RLTTVCPTSKPQTQGLAKDA---WEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKT 299 R+ T T +P + W ++ +L KLG+G + EV+ + Sbjct: 33 RVYTDVNTHRPSEYWDYESHVVEWG-NQDDYQLVRKLGRGKYSEVFEAINITNNEKVV-V 90 Query: 300 LKPGTMSPEAFLQEAQVMKKLRH-EKLVQLYAVVSE---EPIYIVTEYMSKGSLLDFLKG 355 + + +E ++++ LR ++ L +V + +V E+++ Sbjct: 91 KILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD-----FK 145 Query: 356 ETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG-ENLVCKVADFGLARLI 414 + + L + +I + Y M +HRD++ N+++ E+ ++ D+GLA Sbjct: 146 QLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFY 205 Query: 415 EDN-EYTARQGAKFPIKWTAPEAAL-YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNR 472 EY R +++ + PE + Y + D+WS G +L + + + G N Sbjct: 206 HPGQEYNVRVASRY---FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY 262 Query: 473 EVLDQVER------------GYRMPCPPEC------------------------PESLHD 496 + L ++ + Y + P D Sbjct: 263 DQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD 322 Query: 497 LMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 + + R + + R T A YF + Sbjct: 323 FLDKLLRYDHQSRLTARE--AMEHPYFYTV 350 >4WUA-A nrPDB Length = 401 Score = 140 bits (353), Expect = 2e-33, Method: Composition-based stats. Identities = 51/270 (18%), Positives = 88/270 (32%), Gaps = 70/270 (25%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLRH--EK 324 + KLG G F VW+ + VA+K +K E L E +++K +R+ Sbjct: 41 GRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPN 100 Query: 325 ------LVQLYAVVS-----EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373 +VQL I +V E + LL ++ + L LP + + Q+ Sbjct: 101 DPNREMVVQLLDDFKISGVNGTHICMVFE-VLGHHLLKWIIKSNYQGLPLPCVKKIIQQV 159 Query: 374 ASGMAYVERM-NYVHRDLRAANILVG---------------------------------- 398 G+ Y+ +H D++ NIL+ Sbjct: 160 LQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPA 219 Query: 399 ---------------ENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFT 443 E L K+AD G A + + ++ + E + + Sbjct: 220 TAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKH----FTEDIQTRQYRSLEVLIGSGYN 275 Query: 444 IKSDVWSFGILLTELTTKGRVPYPGMVNRE 473 +D+WS + EL T G + E Sbjct: 276 TPADIWSTACMAFELAT-GDYLFEPHSGEE 304 >2X7G-A nrPDB Length = 389 Score = 137 bits (345), Expect = 1e-32, Method: Composition-based stats. Identities = 46/268 (17%), Positives = 87/268 (32%), Gaps = 68/268 (25%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTR-VAIKTLKPGTMSPEAFLQEAQVMKKLR----- 321 + KLG G F VW+ R VA+K +K E L E +++K +R Sbjct: 31 GRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPS 90 Query: 322 HEK---LVQLYAVVSEE-----PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQI 373 +VQL + +V E + LL ++ + L + + + Q+ Sbjct: 91 DPNKDMVVQLIDDFKISGMNGIHVCMVFE-VLGHHLLKWIIKSNYQGLPVRCVKSIIRQV 149 Query: 374 ASGMAYVERM-NYVHRDLRAANILV----------------------------------- 397 G+ Y+ +H D++ NIL+ Sbjct: 150 LQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPA 209 Query: 398 ------------GENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIK 445 + + K+AD G A + + ++ + E + ++ Sbjct: 210 ADLLVNPLDPRNADKIRVKIADLGNACWVHKH----FTEDIQTRQYRSIEVLIGAGYSTP 265 Query: 446 SDVWSFGILLTELTTKGRVPYPGMVNRE 473 +D+WS + EL T G + + Sbjct: 266 ADIWSTACMAFELAT-GDYLFEPHSGED 292 >5UV4-A nrPDB Length = 311 Score = 137 bits (344), Expect = 2e-32, Method: Composition-based stats. Identities = 60/282 (21%), Positives = 116/282 (41%), Gaps = 35/282 (12%) Query: 274 VKLGQGCFGEVWMGTWNGTTRVAIKTLKPG-TMSPEAFLQEAQVMKKLRHEKLVQLYAVV 332 +G+ C G + T + + +K LK G S + F +E + + +RH LV L Sbjct: 31 EIIGRSCHGTSYKATLDNGYMLTVKWLKEGFAKSKKEFSREIKKLGSVRHPNLVPLRGYY 90 Query: 333 ---SEEPIYIVTEYMSKGSLLDFLKGETGK---YLRLPQLVDMAAQIASGMAYVERMNYV 386 E ++++Y SL +L + L Q +++A IA + Y+ + Sbjct: 91 WGPKEHERIMISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARCLDYLHNERVI 150 Query: 387 -HRDLRAANILV-GENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRF-- 442 H +++++N+L+ V D+ L RL+ + + ++ PE + + Sbjct: 151 PHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPPEFSSTSKPCP 210 Query: 443 TIKSDVWSFGILLTELTTK-----------GRVPYPGMVNR-EVLDQVERGYRMPCP--- 487 ++KSDV++FG++L EL T G V V ++ ++V Y Sbjct: 211 SLKSDVYAFGVILLELLTGKIAGEIICMNDGVVDLTDWVRMLDLEERVSECYDRHITGVE 270 Query: 488 -----PECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFT 524 P+ + + + +C R ERP ++ ED + Sbjct: 271 SSEGAPQALDGMLRIALRCIR-SASERP---EVRTVFEDLLS 308 >4F9B-A nrPDB Length = 361 Score = 135 bits (340), Expect = 5e-32, Method: Composition-based stats. Identities = 53/288 (18%), Positives = 95/288 (32%), Gaps = 56/288 (19%) Query: 270 LRLEVKLGQGCFGEVWMGTWN----GTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRH-EK 324 ++E K+G+G F V++ T ++A+K L P T P E Q + + Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIP-TSHPIRIAAELQCLTVAGGQDN 81 Query: 325 LVQL-YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERM 383 ++ + Y + + I Y+ S LD L L ++ + + + + + Sbjct: 82 VMGVKYCFRKNDHVVIAMPYLEHESFLDILNS-----LSFQEVREYMLNLFKALKRIHQF 136 Query: 384 NYVHRDLRAANILVGEN-LVCKVADFGLARLIEDNEYTARQGA----------------- 425 VHRD++ +N L + DFGLA+ D + + Sbjct: 137 GIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQERCSQNKCSIC 196 Query: 426 ----------KFPIKWTAPEAALYGR-FTIKSDVWSFGILLTELTTKGRVPYPGMVNREV 474 + APE T D+WS G++ L + Y + Sbjct: 197 LSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTA 256 Query: 475 LDQVER--------------GYRMPCPPECP-ESLHDLMCQCWRKEPE 507 L Q+ G + C E P + L L + + Sbjct: 257 LAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSS 304 >3T04-A nrPDB Length = 123 Score = 132 bits (332), Expect = 4e-31, Method: Composition-based stats. Identities = 46/128 (35%), Positives = 72/128 (56%), Gaps = 8/128 (6%) Query: 136 PSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFD 195 PSNY+ P +S++ WY G ++R +E LL + N G+FLVRESE++ G +S+ Sbjct: 3 PSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLR--- 57 Query: 196 NAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT-SKPQ 254 V HY+I G Y++S ++FN+L +LV ++S ADGL L P +KP Sbjct: 58 --YEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPT 115 Query: 255 TQGLAKDA 262 G++ + Sbjct: 116 VYGVSPNY 123 >6DC0-A nrPDB Length = 292 Score = 127 bits (319), Expect = 1e-29, Method: Composition-based stats. Identities = 46/212 (21%), Positives = 83/212 (39%), Gaps = 15/212 (7%) Query: 321 RHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 H + + V+ E V G + +++ K LR + + QI S +A+ Sbjct: 56 SHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSR--KRLREEEAARLFKQIVSAVAHC 113 Query: 381 ERMNYVHRDLRAANILVG--ENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEA 436 + V DL+ + E ++ ++ ED+ + + G + +PE Sbjct: 114 HQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGC---PAYVSPEI 170 Query: 437 AL-YGRFTIK-SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESL 494 G ++ K +DVWS G++L L GR P+ + ++ RG + P Sbjct: 171 LNTTGTYSGKAADVWSLGVMLYTLLV-GRYPFHDSDPSALFSKIRRG-QFCIPEHISPKA 228 Query: 495 HDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 L+ R+EP ER T + L +F S Sbjct: 229 RCLIRSLLRREPSERLTAPEI--LLHPWFESV 258 >5CEK-A nrPDB Length = 263 Score = 127 bits (318), Expect = 2e-29, Method: Composition-based stats. Identities = 46/212 (21%), Positives = 83/212 (39%), Gaps = 15/212 (7%) Query: 321 RHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYV 380 H + + V+ E V G + +++ K LR + + QI S +A+ Sbjct: 59 SHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSR--KRLREEEAARLFKQIVSAVAHC 116 Query: 381 ERMNYVHRDLRAANILVG--ENLVCKVADFGLARLI--EDNEYTARQGAKFPIKWTAPEA 436 + V DL+ + E ++ ++ ED+ + + G + +PE Sbjct: 117 HQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGC---PAYVSPEI 173 Query: 437 AL-YGRFTIK-SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESL 494 G ++ K +DVWS G++L L GR P+ + ++ RG + P Sbjct: 174 LNTTGTYSGKAADVWSLGVMLYTLLV-GRYPFHDSDPSALFSKIRRG-QFCIPEHISPKA 231 Query: 495 HDLMCQCWRKEPEERPTFEYLQAFLEDYFTST 526 L+ R+EP ER T + L +F S Sbjct: 232 RCLIRSLLRREPSERLTAPEI--LLHPWFESV 261 >4BNE-A nrPDB Length = 457 Score = 126 bits (317), Expect = 2e-29, Method: Composition-based stats. Identities = 32/120 (26%), Positives = 50/120 (41%), Gaps = 4/120 (3%) Query: 29 GGAFPASQTPSKPA--SADGHRGPSAAFAPAAAEPKLFGGFNSSDT--VTSPQRAGPLAG 84 G S+P S+ + ++ ++ + F+S+D T+P Sbjct: 338 TGINQTGDQVSQPNKHSSVSSYEKNQSYPTDWSDEESNNPFSSTDAKGDTNPFDEDTSPV 397 Query: 85 GVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSD 144 ALYDYE + + +LSFK G+ L + N + W L GQ G P+NYV P Sbjct: 398 MEVRVRALYDYEGQEQDELSFKAGDELTKMENEDEQGWCKGRLDNGQVGLYPANYVEPIQ 457 >5M07-A nrPDB Length = 276 Score = 121 bits (303), Expect = 9e-28, Method: Composition-based stats. Identities = 46/263 (17%), Positives = 94/263 (35%), Gaps = 45/263 (17%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKP----GTMSPEAFLQEAQVMK 318 + + LG GEV++ G A+K L P F +E +V Sbjct: 26 GVTFAGYTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDEFRRRFQRETEVAA 85 Query: 319 KLRHEKLVQLYAVVS-EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGM 377 +L H +++++ + ++I +Y+ + L + +++ + +A + Sbjct: 86 RLFHPHILEVHDRGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAGAL 145 Query: 378 AYVERMNYVHRDLRAANILVGE----NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTA 433 Y + +HRD+ AN+++ + +ADFG+A + A Sbjct: 146 DYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ---------------PSYPA 190 Query: 434 PEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP-CPPECPE 492 PE + ++D ++ + L G P V+R + P PP+ Sbjct: 191 PELSAGADVDGRADQYALALTAIHLFA-GAPP------------VDRSHTGPLQPPKLSA 237 Query: 493 SLHDL------MCQCWRKEPEER 509 DL + + P +R Sbjct: 238 FRPDLARLDGVLSRALATAPADR 260 >5L2Q-C nrPDB Length = 320 Score = 120 bits (300), Expect = 2e-27, Method: Composition-based stats. Identities = 39/285 (13%), Positives = 98/285 (34%), Gaps = 46/285 (16%) Query: 285 WMGTWNGTTR-VAIKTLKPGTMSPEAFLQ------------EAQVMKKLR-HEKLVQLYA 330 + +GT +K L + E ++ L + +V + Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHG 92 Query: 331 VVSE-------------------EPIYIVTEYMSKGS----LLDFLKGE----TGKYLRL 363 + + + I +V + + D + + K L Sbjct: 93 LFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSE 152 Query: 364 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLV-CKVADFGLARLIEDNEYTAR 422 + V + + + + + N VHRDL+ N+++ + + +F L + + + Sbjct: 153 RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLK 212 Query: 423 QGAKFPIKWTAPEAALYGRF-TIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG 481 + + +P+ + SD+W+ G++L + G+ P+ + +E+ +++ Sbjct: 213 D-QRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTML-YGQFPFYDSIPQELFRKIKAA 270 Query: 482 -YRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTS 525 Y +P E+ L+ + +P++R + L S Sbjct: 271 EYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLEALSAIIAS 315 >2PZI-A nrPDB Length = 681 Score = 119 bits (298), Expect = 4e-27, Method: Composition-based stats. Identities = 57/281 (20%), Positives = 104/281 (37%), Gaps = 32/281 (11%) Query: 261 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNG--TTRVAIKTL--KPGTMSPEAFLQEAQV 316 + +I ++ + G G +++ V +K L + + E Q Sbjct: 73 NPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQF 132 Query: 317 MKKLRHEKLVQLYAVVSEEPI------YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMA 370 + ++ H +VQ++ V YIV EY+ SL K G+ L + + + Sbjct: 133 LAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL----KRSKGQKLPVAEAIAYL 188 Query: 371 AQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIK 430 +I ++Y+ + V+ DL+ NI++ E K+ D G I Y Sbjct: 189 LEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYL-----YGTPG 242 Query: 431 WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP-PE 489 + APE G T+ +D+++ G L LT + R + G P + Sbjct: 243 FQAPEIVRTGP-TVATDIYTVGRTLAALTL-------DLPTRN--GRYVDGLPEDDPVLK 292 Query: 490 CPESLHDLMCQCWRKEPEERP-TFEYLQAFLEDYFTSTEPQ 529 +S L+ + +P +R T E + A L Q Sbjct: 293 TYDSYGRLLRRAIDPDPRQRFTTAEEMSAQLTGVLREVVAQ 333 >5GZA-A nrPDB Length = 290 Score = 118 bits (297), Expect = 4e-27, Method: Composition-based stats. Identities = 64/293 (21%), Positives = 108/293 (36%), Gaps = 55/293 (18%) Query: 267 RESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLV 326 R +R +GQG +V++ W G +VA+ L + FL +++ L+ +V Sbjct: 24 RSGVRRVKLIGQGAVKKVYLSEWQG-QKVALSVLSSD-QYADDFLHGLSMLRALQSSHVV 81 Query: 327 QLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 L V E+ ++ VTEY GS+L + R Q+ + YV + Y+ Sbjct: 82 TLVGVCEEDAVF-VTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQL--AIDYVAFLAYL 138 Query: 387 HRDLRAANILVGENLVCK-VADFGLA---RLIEDNEYTARQGAKFPIK-----------W 431 H ++ N + K ++ F LA RL+ ++ + K + + Sbjct: 139 HSSPAGIRVMCDSNDLHKTLSQFLLASDMRLLANDLDALPEVEKGGLGVKCGHHELTGDF 198 Query: 432 TAPEAA------------LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVE 479 APE + K+D+W ++P V R +L V Sbjct: 199 VAPEQLWPYGEDFSFSDEAMPGYDEKTDIW-------------KIP---DVTRFLLGDVL 242 Query: 480 RGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEY-LQAFLEDYFTSTEPQYQ 531 G + L + +C RKE RPT L + Y + E Q Q Sbjct: 243 GGDVIHF------HLFQIYSECKRKEAHMRPTAREVLSVYRSVYDSMMESQSQ 289 >4Y12-A nrPDB Length = 375 Score = 118 bits (297), Expect = 5e-27, Method: Composition-based stats. Identities = 57/281 (20%), Positives = 104/281 (37%), Gaps = 32/281 (11%) Query: 261 DAWEIPRESLRLEVKLGQGCFGEVWMGTWNG--TTRVAIKTL--KPGTMSPEAFLQEAQV 316 + +I ++ + G G +++ V +K L + + E Q Sbjct: 112 NPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMAERQF 171 Query: 317 MKKLRHEKLVQLYAVVSEEPI------YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMA 370 + ++ H +VQ++ V YIV EY+ SL K G+ L + + + Sbjct: 172 LAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSL----KRSKGQKLPVAEAIAYL 227 Query: 371 AQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIK 430 +I ++Y+ + V+ DL+ NI++ E K+ D G I Y Sbjct: 228 LEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYL-----YGTPG 281 Query: 431 WTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP-PE 489 + APE G T+ +D+++ G L LT + R + G P + Sbjct: 282 FQAPEIVRTGP-TVATDIYTVGRTLAALTL-------DLPTRN--GRYVDGLPEDDPVLK 331 Query: 490 CPESLHDLMCQCWRKEPEERP-TFEYLQAFLEDYFTSTEPQ 529 +S L+ + +P +R T E + A L Q Sbjct: 332 TYDSYGRLLRRAIDPDPRQRFTTAEEMSAQLTGVLREVVAQ 372 >5OAT-A nrPDB Length = 411 Score = 117 bits (293), Expect = 1e-26, Method: Composition-based stats. Identities = 54/337 (16%), Positives = 111/337 (32%), Gaps = 75/337 (22%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGTWNGTTR------VAIKTLKPGTMSP------EAFL 311 I L L + +G G V+ A+K + + +A Sbjct: 7 PITLNDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMY 66 Query: 312 QE---AQVM-----------------KKLR-HEKLVQLYAVVSEE--------------- 335 +E A++ K L H +V +++V ++ Sbjct: 67 RETVPARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEG 126 Query: 336 ---PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRA 392 ++++ + +L FL L L + G+A++ HRDL++ Sbjct: 127 RNMSLFLLMKRYDC-NLQSFLSTAPSTRTSLLLLAQLL----EGVAHMTAHGIAHRDLKS 181 Query: 393 ANILVG----ENLVCKVADFGLARLIEDNEYTARQGA-----KFPIKWTAPEAALYGR-- 441 N+L+ E+ + ++DFG + N + + APE Sbjct: 182 DNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGT 241 Query: 442 -----FTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496 ++ K+D+W+ G + E+ P+ G + + + G P E P + Sbjct: 242 FSVLNYS-KADLWAVGAIAYEIF-NCHNPFYGPSRLKNFN-YKEGDLPKLPDEVPTVIQA 298 Query: 497 LMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPG 533 L+ ++ P +R E + + + +PG Sbjct: 299 LVANLLKRNPNKRLDPEVAANVCQLFLWAPSTWLKPG 335 >4XZ1-A nrPDB Length = 262 Score = 114 bits (285), Expect = 1e-25, Method: Composition-based stats. Identities = 38/107 (35%), Positives = 53/107 (49%), Gaps = 6/107 (5%) Query: 147 QAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYK 206 + WY +TR E+ER L + G FL+R + +G Y LS+ G V HY Sbjct: 162 ERMPWYHSSLTREEAERKLYSGAQTDGKFLLRPRKE-QGTYALSL-----IYGKTVYHYL 215 Query: 207 IRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKP 253 I + +G + I T+F++L QLV Y ADGL + L CP S Sbjct: 216 ISQDKAGKYCIPEGTKFDTLWQLVEYLKLKADGLIYCLKEACPNSSA 262 Score = 71.6 bits (174), Expect = 8e-13, Method: Composition-based stats. Identities = 34/137 (24%), Positives = 54/137 (39%), Gaps = 8/137 (5%) Query: 143 SDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV 202 D +++G I+R E+E L A G FL+R+ + G Y LS+ Sbjct: 5 PDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFH---- 60 Query: 203 KHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC-PTSKPQTQG--LA 259 H+ I + +G + I +L +YS+ DGL L C S + Q Sbjct: 61 -HFPIERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFD 119 Query: 260 KDAWEIPRESLRLEVKL 276 + R+ +R KL Sbjct: 120 SLRDAMVRDYVRQTWKL 136 >1A81-A nrPDB Length = 254 Score = 113 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 37/104 (35%), Positives = 53/104 (50%), Gaps = 6/104 (5%) Query: 147 QAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYK 206 + W+ GKI+R ESE+++L G FL+R + G+Y L + V HY+ Sbjct: 156 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLH-----EGKVLHYR 209 Query: 207 IRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT 250 I K +G I +F++L QLV +YS ADGL LT C Sbjct: 210 IDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQK 253 Score = 80.8 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 36/130 (27%), Positives = 55/130 (42%), Gaps = 8/130 (6%) Query: 145 SIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKH 204 S ++FG ITR E+E L+ G +L+R+S G + LSV A G H Sbjct: 1 SANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSV-----AHGRKAHH 55 Query: 205 YKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC---PTSKPQTQGLAKD 261 Y I + +G + I S L Y+S+ +DGL L +P+T Sbjct: 56 YTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDL 115 Query: 262 AWEIPRESLR 271 + RE ++ Sbjct: 116 KENLIREYVK 125 >6EQI-C nrPDB Length = 433 Score = 108 bits (269), Expect = 8e-24, Method: Composition-based stats. Identities = 51/337 (15%), Positives = 107/337 (31%), Gaps = 81/337 (24%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTT------RVAIKTL------KPGTMSPEAFLQE-- 313 + L L + +GC V+ ++A+K + T +A +E Sbjct: 15 DELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETV 74 Query: 314 -------------AQVMKKLR-----HEKLVQLYAVVSEE-------------------- 335 + + + H +V++Y+V ++ Sbjct: 75 PAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRIN 134 Query: 336 --------PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVH 387 +++V + +L ++L+ +T + + + +Q+ +A++ N H Sbjct: 135 PEGSGRNMSLFLVMKRYDC-TLKEYLRDKTP---NMRSSILLLSQLLEAVAHMNIHNISH 190 Query: 388 RDLRAANILV-----GENLVCKVADFGLARLIEDNEYTAR-----QGAKFPIKWTAPEAA 437 RDL++ NILV + DFG + N Q APE A Sbjct: 191 RDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIA 250 Query: 438 LYGRFT------IKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP 491 T KSD+W+ G + E+ P+ + + + P P Sbjct: 251 NAKPGTFSWLNYKKSDLWAVGAIAYEIFNI-DNPFYDKTMKLLSKSYKEEDLPELPDTIP 309 Query: 492 ESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEP 528 + +L+ + +R + + Y + Sbjct: 310 FIIRNLVSNMLSRSTNKRLDCDVAATVAQLYLWAPSS 346 >6J6I-B nrPDB Length = 351 Score = 106 bits (265), Expect = 3e-23, Method: Composition-based stats. Identities = 47/283 (16%), Positives = 97/283 (34%), Gaps = 37/283 (13%) Query: 284 VWMGTWNGTTR---VAIKTLKPGTMSPEAFL-QEAQ---VM--KKLRHEKLVQLYAVVSE 334 V+ + G IK ++ + +E V+ + H +QL E Sbjct: 70 VYYKWYRGEIEDRSYMIKRFSEDEITGKRHRVKEVYNDIVLSARMSNHSNFLQLLGCCLE 129 Query: 335 EPI-YIVTEYMSKGSLLD---FLKGETGKYLRLPQLVDMAAQIASGMAYVER---MNYVH 387 P +V E+ G++ + L + + +IA+ + Y+ +H Sbjct: 130 FPFPVLVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIH 189 Query: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQG-AKFPIKWTAPEAALYGRFTIKS 446 RD++ ++ + +N K++D + + + + + P T + Sbjct: 190 RDVKPMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFVTEYT 249 Query: 447 DVWSFGILLTELTTKGRVPYPGMVNRE---VLDQVERGYRMPCPPEC--PESLHD----- 496 DV+SFGI L + T G+ + + + +L V E P + D Sbjct: 250 DVYSFGICLLVIIT-GKPAIMTISDGDLQGILSLVRELCENGKLDEVIDPRLMKDITSGQ 308 Query: 497 ---------LMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQY 530 L +C ++ E+RP + L+ S + Sbjct: 309 RLQVEACVVLALRCCKERDEDRPKMIQVAKELKQIEASLKNSS 351 >2EKX-A nrPDB Length = 110 Score = 105 bits (263), Expect = 4e-23, Method: Composition-based stats. Identities = 32/111 (28%), Positives = 53/111 (47%), Gaps = 3/111 (2%) Query: 139 YVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSV-SDFDNA 197 + S + +W+ G I+R +SE+LL + G F+VR S G Y +S+ S N Sbjct: 1 GSSGSSGLDDYDWFAGNISRSQSEQLL-RQKGKEGAFMVRNSSQV-GMYTVSLFSKAVND 58 Query: 198 KGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVC 248 K VKHY + Y+ F+S+ +L+ Y+ ++ G+ RL Sbjct: 59 KKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPV 109 >4H1O-A nrPDB Length = 560 Score = 105 bits (262), Expect = 6e-23, Method: Composition-based stats. Identities = 37/124 (29%), Positives = 59/124 (47%), Gaps = 13/124 (10%) Query: 135 IPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDF 194 P N P+ +E W+ G ++ +E+E+LL + G+FLVRES++ G + LSV Sbjct: 121 YPLNCADPT----SERWFHGHLSGKEAEKLL-TEKGKHGSFLVRESQSHPGDFVLSVRTG 175 Query: 195 D-----NAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCP 249 D N V H I + + + +F+SL LV +Y K+ + L TV Sbjct: 176 DDKGESNDGKSKVTHVMI-RCQELKYDVGGGERFDSLTDLVEHYKKNP--MVETLGTVLQ 232 Query: 250 TSKP 253 +P Sbjct: 233 LKQP 236 Score = 80.0 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 34/120 (28%), Positives = 53/120 (44%), Gaps = 9/120 (7%) Query: 144 DSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVK 203 + + W+ IT E+E LLL G+FL R S++ G + LSV + V Sbjct: 20 QGMTSRRWFHPNITGVEAENLLLT-RGVDGSFLARPSKSNPGDFTLSVR-----RNGAVT 73 Query: 204 HYKIRKLDSGGFY-ITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDA 262 H KI+ ++GG+Y + +F +L +LV YY +H L + V P Sbjct: 74 HIKIQ--NTGGYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSE 131 >2AUG-A nrPDB Length = 126 Score = 104 bits (260), Expect = 9e-23, Method: Composition-based stats. Identities = 35/122 (28%), Positives = 59/122 (48%), Gaps = 12/122 (9%) Query: 133 GYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVS 192 G +P +++ W+ KI+R E++RL++ G FLVR+S++ + LS+S Sbjct: 13 GLVPR---GSHMIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMS 69 Query: 193 DFDNAKGLNVKHYKIRKL-DSGGFYIT---SRTQFNSLQQLVAYYSKHADGLCHRLTTVC 248 G +KH++I + D G + T T+F L QLV +Y + L +L C Sbjct: 70 H-----GQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYC 124 Query: 249 PT 250 Sbjct: 125 AR 126 >5U06-A nrPDB Length = 120 Score = 103 bits (257), Expect = 2e-22, Method: Composition-based stats. Identities = 36/122 (29%), Positives = 56/122 (45%), Gaps = 10/122 (8%) Query: 136 PSNYVAPSDSIQAEE-WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDF 194 P++ + S +I + W+ G+I+R ES+RL+ G FLVRES+ + LS+ Sbjct: 3 PASGTSLSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLSLCHL 62 Query: 195 DNAKGLNVKHYKIR-KLDSGGFYIT---SRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT 250 VKHY I + G Y + +T+F L QLV ++ + L L C Sbjct: 63 Q-----KVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCTR 117 Query: 251 SK 252 Sbjct: 118 VA 119 >2B3O-A nrPDB Length = 532 Score = 101 bits (253), Expect = 5e-22, Method: Composition-based stats. Identities = 38/137 (27%), Positives = 59/137 (43%), Gaps = 15/137 (10%) Query: 108 GERLQIVNNTEGDWWLAHSLSTGQTGYI-----PSNYVAPSDSIQAEEWYFGKITRRESE 162 GE+ + + + + G I P N P+ +E WY G ++ ++E Sbjct: 66 GEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPT----SERWYHGHMSGGQAE 121 Query: 163 RLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKG----LNVKHYKIRKLDSGGFYIT 218 LL A+ TFLVRES + G + LSV G L V H K+ + G + + Sbjct: 122 TLL-QAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVM-CEGGRYTVG 179 Query: 219 SRTQFNSLQQLVAYYSK 235 F+SL LV ++ K Sbjct: 180 GLETFDSLTDLVEHFKK 196 Score = 73.1 bits (178), Expect = 3e-13, Method: Composition-based stats. Identities = 32/124 (25%), Positives = 51/124 (41%), Gaps = 15/124 (12%) Query: 148 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKI 207 W+ ++ ++E LL G+FL R S +G + LSV G V H +I Sbjct: 1 MVRWFHRDLSGLDAETLL-KGRGVHGSFLARPSRKNQGDFSLSVRV-----GDQVTHIRI 54 Query: 208 RKLDSGGFY-ITSRTQFNSLQQLVAYYS------KHADGLCHRLTTVCPTSKPQTQGLAK 260 + +SG FY + +F +L +LV YY+ + DG L S P ++ Sbjct: 55 Q--NSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYH 112 Query: 261 DAWE 264 Sbjct: 113 GHMS 116 >3PS5-A nrPDB Length = 595 Score = 101 bits (251), Expect = 9e-22, Method: Composition-based stats. Identities = 38/137 (27%), Positives = 59/137 (43%), Gaps = 15/137 (10%) Query: 108 GERLQIVNNTEGDWWLAHSLSTGQTGYI-----PSNYVAPSDSIQAEEWYFGKITRRESE 162 GE+ + + + + G I P N P+ +E WY G ++ ++E Sbjct: 66 GEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPT----SERWYHGHMSGGQAE 121 Query: 163 RLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKG----LNVKHYKIRKLDSGGFYIT 218 LL A+ TFLVRES + G + LSV G L V H K+ + G + + Sbjct: 122 TLL-QAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVM-CEGGRYTVG 179 Query: 219 SRTQFNSLQQLVAYYSK 235 F+SL LV ++ K Sbjct: 180 GLETFDSLTDLVEHFKK 196 Score = 72.3 bits (176), Expect = 5e-13, Method: Composition-based stats. Identities = 32/124 (25%), Positives = 51/124 (41%), Gaps = 15/124 (12%) Query: 148 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKI 207 W+ ++ ++E LL G+FL R S +G + LSV G V H +I Sbjct: 1 MVRWFHRDLSGLDAETLL-KGRGVHGSFLARPSRKNQGDFSLSVRV-----GDQVTHIRI 54 Query: 208 RKLDSGGFY-ITSRTQFNSLQQLVAYYS------KHADGLCHRLTTVCPTSKPQTQGLAK 260 + +SG FY + +F +L +LV YY+ + DG L S P ++ Sbjct: 55 Q--NSGDFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYH 112 Query: 261 DAWE 264 Sbjct: 113 GHMS 116 >5JMQ-A nrPDB Length = 446 Score = 100 bits (249), Expect = 1e-21, Method: Composition-based stats. Identities = 38/118 (32%), Positives = 57/118 (48%), Gaps = 15/118 (12%) Query: 85 GVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV---- 140 FVA+ DY + ET LSF +GE++ I+ T DWW G GYIP+N++ Sbjct: 44 QPEEFVAIADYTATDETQLSFLRGEKILILRQTTADWWWGER--AGCCGYIPANHLGKQL 101 Query: 141 ---APSDSIQAEEWYFGKITRRESERLLLNAENPRGT----FLVRESETTKGAYCLSV 191 P D+ Q EE++ T + +L A+ PR T +++ E+ K L V Sbjct: 102 EEYDPEDTWQDEEYFDSYGTLKLHLEML--ADQPRTTKYHSVILQNKESLKDKVILDV 157 >6CMQ-A nrPDB Length = 427 Score = 100 bits (248), Expect = 2e-21, Method: Composition-based stats. Identities = 34/111 (30%), Positives = 55/111 (49%), Gaps = 9/111 (8%) Query: 148 AEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFD-----NAKGLNV 202 +E W+ G ++ +E+E+LL + G+FLVRES++ G + LSV D N V Sbjct: 7 SERWFHGHLSGKEAEKLL-TEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKV 65 Query: 203 KHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKP 253 H I + + + +F+SL LV +Y K+ + L TV +P Sbjct: 66 THVMI-RCQELKYDVGGGERFDSLTDLVEHYKKNP--MVETLGTVLQLKQP 113 >1NRV-A nrPDB Length = 105 Score = 98.1 bits (243), Expect = 8e-21, Method: Composition-based stats. Identities = 27/106 (25%), Positives = 51/106 (48%), Gaps = 9/106 (8%) Query: 147 QAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYK 206 + + W+ G+I+R ES R++ G FL+R+S++ A+ L++ +K+++ Sbjct: 3 RTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHHQ-----KIKNFQ 57 Query: 207 IRKLDSGGFYIT----SRTQFNSLQQLVAYYSKHADGLCHRLTTVC 248 I + G T+F+ L QLV +Y + L +L C Sbjct: 58 ILPCEDDGQTFFSLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHC 103 >4JRN-A nrPDB Length = 372 Score = 96.6 bits (239), Expect = 3e-20, Method: Composition-based stats. Identities = 51/285 (17%), Positives = 95/285 (33%), Gaps = 56/285 (19%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEAFL----QEAQVMKKLR- 321 +L LG G F V+ T T +A+K + + +E+ + Sbjct: 68 RTLVRGAPLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSL 127 Query: 322 ---------------HEKLVQLYAVVSEEPI-----------YIVTEYMSKGSLLDFLK- 354 +V L + + Y + ++ + + Sbjct: 128 AKTAKDAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISW 187 Query: 355 -----GETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFG 409 L + +++Q +A V+ VH D++ AN L+ ++ + DFG Sbjct: 188 VFGDASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFG 247 Query: 410 LARLIEDNEYTARQGAKFPIKWTAPEA---ALYGRFTIKSDVWSFGILLTELTTKGRV-P 465 R+ + A + PE A +T +D W GI L + K R P Sbjct: 248 TYRI-----NNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTP 302 Query: 466 YPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERP 510 G + D + + CP PE + DL+ ++P++R Sbjct: 303 ADG-----IWDYL---HFADCPST-PELVQDLIRSLLNRDPQKRM 338 >2LQW-A nrPDB Length = 303 Score = 95.8 bits (237), Expect = 4e-20, Method: Composition-based stats. Identities = 38/134 (28%), Positives = 54/134 (40%), Gaps = 10/134 (7%) Query: 144 DSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVK 203 DS WY G ++R+E++ L G FLVR+S T G Y LSVS + V Sbjct: 7 DSSDRSAWYMGPVSRQEAQTRL--QGQRHGMFLVRDSSTCPGDYVLSVS-----ENSRVS 59 Query: 204 HYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQG-LAKDA 262 HY I L + F I + F+ L L+ +Y H L P G ++ Sbjct: 60 HYIINSLPNRRFKIGDQE-FDHLPALLEFYKIHYLD-TTTLIEPAPRYPSPPMGSVSAPN 117 Query: 263 WEIPRESLRLEVKL 276 ++L L Sbjct: 118 LPTAEDNLEYVRTL 131 Score = 71.2 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 22/60 (36%), Positives = 27/60 (45%), Gaps = 1/60 (1%) Query: 83 AGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAP 142 + LYD+ DL FKKGE L I+ E WW A + G+ G IP YV Sbjct: 122 EDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARN-KDGRVGMIPVPYVEK 180 >6EAS-A nrPDB Length = 308 Score = 95.4 bits (236), Expect = 5e-20, Method: Composition-based stats. Identities = 46/263 (17%), Positives = 99/263 (37%), Gaps = 41/263 (15%) Query: 285 WMGTWNGTTRVAIKTLKPGTMSPEAFLQE--------AQVMKKLRHEKLVQLYAVVSEEP 336 + GT + +A+ S + + +E + K+ H+ + L EE Sbjct: 57 YKGTLSSGVEIAVA--SSLVTSAKDWSKENESQYRKKITNLSKVSHKNFMNLLGYCEEEH 114 Query: 337 IY---IVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN--YVHRDLR 391 + +V EY G+L + L + L + ++ IA + ++ ++ R+ Sbjct: 115 PFTRVMVFEYAPNGTLFEHLHVREAEKLDWMARLRISMGIAYCLEHMHQLQTPAALRNFD 174 Query: 392 AANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 451 + + + ++ KV+D + + T F E + + Sbjct: 175 STTVYLTDDFAAKVSDLEFWNDAKGHNSTTNNELAFSPD-M--EDIVRK----------Y 221 Query: 452 GILLTELTTKGRVPY---PGMVNREVLDQVERGYRMP---------CPPECPESLHDLMC 499 G++L E+ T GRVP G + V E G R+ P + +L +++ Sbjct: 222 GMVLLEILT-GRVPSSEDDGPLENWVSRYFEGGMRLEELIDPSIGFFPEDTARALCEVVR 280 Query: 500 QCWRKEPEERPTFEYLQAFLEDY 522 C ++P++RP + + A + + Sbjct: 281 SCIDRDPKKRPQMKEVAARMREI 303 >2CRH-A nrPDB Length = 138 Score = 93.9 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 35/141 (24%), Positives = 63/141 (44%), Gaps = 11/141 (7%) Query: 124 AHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETT 183 S S+G+ + + P + WY G + R +E +L N GTFLVR+ Sbjct: 1 GSSGSSGKAEAEQNWWEGPPQDLSVHLWYAGPMERAGAESILANRS--DGTFLVRQRVKD 58 Query: 184 KGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHR 243 + +S+ + VKH KI + G + IT + F L +LV +Y +++ C + Sbjct: 59 AAEFAISIK-----YNVEVKHIKIMTAE-GLYRITEKKAFRGLTELVEFYQQNSLKDCFK 112 Query: 244 ---LTTVCPTSKPQTQGLAKD 261 T P +P+ + +++ Sbjct: 113 SLDTTLQFPFKEPEKRTISRS 133 >5GZ9-A nrPDB Length = 305 Score = 92.0 bits (227), Expect = 5e-19, Method: Composition-based stats. Identities = 61/289 (21%), Positives = 103/289 (35%), Gaps = 55/289 (19%) Query: 267 RESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLV 326 R +R ++G+G V++ W +VA+ L M E FL Q++K L+ E +V Sbjct: 33 RTEVRQLKRVGEGAVKRVFLSEWKE-HKVALSRLTRLEM-KEDFLHGLQMLKSLQSEHVV 90 Query: 327 QLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYV 386 L E+ I+TEY GSL + + + Q+ M YV +NY+ Sbjct: 91 TLVGYCEEDG-TILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQL--AMEYVSIINYL 147 Query: 387 HRDLRAANILVGENLVCK-VADFGLARLI--------------EDNEYTARQGAK-FPIK 430 H ++ N + K ++ + L D+ + G + Sbjct: 148 HHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRELHGD 207 Query: 431 WTAPEAA------------LYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV 478 + APE L + K D+W ++P V+ +L V Sbjct: 208 FVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW-------------KIP---DVSSFLLGHV 251 Query: 479 ERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTE 527 E + L D+ C + P ERPT + + + F S Sbjct: 252 EGSDMVRF------HLFDIHKACKSQIPAERPTAQNVLDAYQRVFHSLR 294 >5CLR-A nrPDB Length = 451 Score = 90.4 bits (223), Expect = 2e-18, Method: Composition-based stats. Identities = 46/266 (17%), Positives = 96/266 (36%), Gaps = 42/266 (15%) Query: 283 EVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEP---IYI 339 +V+ + +K++K S F E + KL +L E YI Sbjct: 97 KVYA--LDDGKTYFLKSVKIDAESLTEFTNEKDTLSKLG-----RLVGTFFNEQTQVHYI 149 Query: 340 VTEYMSKGSLLDFLKGETGKYLRLP---QLVDMAAQIASGMAYVERMNYVHRDLRAANIL 396 +T ++ L + K + L +++ + + + + +HRDL+ NI+ Sbjct: 150 LTTFIKGIDLSRY-KNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNIM 208 Query: 397 VGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR---FTIKSDVWSFGI 453 + ++ C + DFG + ++ + + + APE F+ SD+++ Sbjct: 209 LDADMQCHLVDFGSS----SSDKEPKPASWGTASYLAPELNAQEDFIAFSQVSDLFALAY 264 Query: 454 LLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLM-----------CQCW 502 L EL P+ + +V ++ + + E + LM + Sbjct: 265 SLDELFN----PFRQVKFAKVDIGIKNKHLVLLHAEIEACITGLMSNETSVRTLYFSRIL 320 Query: 503 RKE-----PEERPT-FEYLQAFLEDY 522 + + + RP F YL L + Sbjct: 321 QLQRVPESFKSRPEAFTYLIMLLTQW 346 >5M6U-B nrPDB Length = 724 Score = 87.4 bits (215), Expect = 1e-17, Method: Composition-based stats. Identities = 35/151 (23%), Positives = 64/151 (42%), Gaps = 18/151 (11%) Query: 135 IPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRE-SETTKGAYCLSVSD 193 + +N + + S+Q EWY+G I+R E L + GTFLVR+ S G Y L++ Sbjct: 317 VANNGMNNNMSLQDAEWYWGDISREEVNEKL--RDTADGTFLVRDASTKMHGDYTLTLR- 373 Query: 194 FDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHAD---------GLCHRL 244 KG N K KI D G + + F+S+ +L+ +Y + L + + Sbjct: 374 ----KGGNNKLIKIFHRD-GKYGFSDPLTFSSVVELINHYRNESLAQYNPKLDVKLLYPV 428 Query: 245 TTVCPTSKPQTQGLAKDAWEIPRESLRLEVK 275 + + + ++ + + + K Sbjct: 429 SKYQQDQVVKEDNIEAVGKKLHEYNTQFQEK 459 Score = 58.1 bits (139), Expect = 9e-09, Method: Composition-based stats. Identities = 38/146 (26%), Positives = 58/146 (39%), Gaps = 15/146 (10%) Query: 114 VNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRG 173 V + + WL + + Q + + P + W G R ++E LL G Sbjct: 589 VRQKKLNEWLGNENTEDQYSLVEDDEDLPHH--DEKTWNVGSSNRNKAENLL--RGKRDG 644 Query: 174 TFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYY 233 TFLVRES + +G Y SV VKH I K +G + ++SL++LV +Y Sbjct: 645 TFLVRES-SKQGCYACSVVVD-----GEVKHCVINKTATGYGFAEPYNLYSSLKELVLHY 698 Query: 234 SK-----HADGLCHRLTTVCPTSKPQ 254 H D L L + + Sbjct: 699 QHTSLVQHNDSLNVTLAYPVYAQQRR 724 Score = 40.7 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 17/69 (24%), Positives = 29/69 (42%), Gaps = 15/69 (21%) Query: 88 TFVALYDYESRTETDLSFKKGERLQI-------VNNTEGD--------WWLAHSLSTGQT 132 + ALYDY+ E D+ G+ L + + ++G W ++ +TG+ Sbjct: 7 QYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEEIGWLNGYNETTGER 66 Query: 133 GYIPSNYVA 141 G P YV Sbjct: 67 GDFPGTYVE 75 >2LCT-A nrPDB Length = 107 Score = 87.0 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 28/101 (27%), Positives = 46/101 (45%), Gaps = 8/101 (7%) Query: 144 DSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVK 203 + WY G + R +E +L N GTFLVR+ + +S+ + VK Sbjct: 4 QDLSVHLWYAGPMERAGAESILANRS--DGTFLVRQRVKDAAEFAISIK-----YNVEVK 56 Query: 204 HYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRL 244 H KI + G + IT + F L +LV +Y +++ C + Sbjct: 57 HIKIMTAE-GLYRITEKKAFRGLTELVEFYQQNSLKDCFKS 96 >2KK6-A nrPDB Length = 116 Score = 87.0 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 30/113 (26%), Positives = 50/113 (44%), Gaps = 11/113 (9%) Query: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205 + ++WY G I R E++ LL G FLVRES G Y LSV +H+ Sbjct: 14 LAEQDWYHGAIPRIEAQELLKKQ----GDFLVRESHGKPGEYVLSVYSDGQR-----RHF 64 Query: 206 KIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGL 258 I+ +D+ Y T F+++ QL+ ++ + + V P+ + Sbjct: 65 IIQYVDN--MYRFEGTGFSNIPQLIDHHYTTKQVITKKSGVVLLNPIPKDKKW 115 >2LAV-A nrPDB Length = 361 Score = 87.0 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 46/311 (14%), Positives = 110/311 (35%), Gaps = 44/311 (14%) Query: 257 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV---AIKTLKPGTMSPEAFLQE 313 + + ++ ++ ++ + +GQG FG +++ N + V A +K E Sbjct: 24 AVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTE 83 Query: 314 AQVMKKLRHEKLVQ--------------------LYAVVSEEPIYIVTEYMSKGSLLDFL 353 + ++ + +Q L+ + +++ + GS L + Sbjct: 84 LKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMD--RFGSDLQKI 141 Query: 354 KGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG--ENLVCKVADFGLA 411 K ++ ++ +I + Y+ YVH D++A+N+L+ + D+GLA Sbjct: 142 YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 201 Query: 412 -RLIEDNEYTA-----RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 465 R + + ++ I++T+ +A + + D+ G + + T G +P Sbjct: 202 YRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLP 260 Query: 466 YPG---------MVNREVLDQVERGYRMPCP-PECPESLHDLMCQCWRKEPEERPTFEYL 515 + + + P P + M + E+P +E L Sbjct: 261 WEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENL 320 Query: 516 QAFLEDYFTST 526 + L + Sbjct: 321 RDILLQGLKAI 331 >2RSV-A nrPDB Length = 403 Score = 87.0 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 46/311 (14%), Positives = 110/311 (35%), Gaps = 44/311 (14%) Query: 257 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRV---AIKTLKPGTMSPEAFLQE 313 + + ++ ++ ++ + +GQG FG +++ N + V A +K E Sbjct: 31 AVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTE 90 Query: 314 AQVMKKLRHEKLVQ--------------------LYAVVSEEPIYIVTEYMSKGSLLDFL 353 + ++ + +Q L+ + +++ + GS L + Sbjct: 91 LKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMD--RFGSDLQKI 148 Query: 354 KGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG--ENLVCKVADFGLA 411 K ++ ++ +I + Y+ YVH D++A+N+L+ + D+GLA Sbjct: 149 YEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLA 208 Query: 412 -RLIEDNEYTA-----RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVP 465 R + + ++ I++T+ +A + + D+ G + + T G +P Sbjct: 209 YRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLT-GHLP 267 Query: 466 YPG---------MVNREVLDQVERGYRMPCP-PECPESLHDLMCQCWRKEPEERPTFEYL 515 + + + P P + M + E+P +E L Sbjct: 268 WEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENL 327 Query: 516 QAFLEDYFTST 526 + L + Sbjct: 328 RDILLQGLKAI 338 >4O1O-A nrPDB Length = 717 Score = 86.6 bits (213), Expect = 3e-17, Method: Composition-based stats. Identities = 56/322 (17%), Positives = 118/322 (36%), Gaps = 63/322 (19%) Query: 228 QLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPR------ESLRL----EVKLG 277 LV + H G R KPQ+ + + R L++ E K+ Sbjct: 298 DLVKFLRLHKAGEDFRP--PAENWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIA 355 Query: 278 QGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR-HEKLVQLYAVVSEE- 335 G +++G + VA+K G+ + QE ++ R ++ +V Y S+ Sbjct: 356 DTAEGGIYLGLYED-QEVAVKRFSEGSTRGQ---QEVSCLQSSRANDNVVTFYGSESDGS 411 Query: 336 --PIYIVTEYMSKGSLLDFLKGETGKYLRLPQ---LVDMAAQIASGMAYVERMNYVHRDL 390 + + + + +L + L G + + ++ + + + + R Y H+DL Sbjct: 412 CLHVCLA---LCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDL 468 Query: 391 RAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS 450 + NIL+ +ADF + ++ ++ D+ + Sbjct: 469 QPQNILIDSKNGTFLADFDKSIKWAEDPQKIKR-----------------------DLEA 505 Query: 451 FGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRK--EPEE 508 G+L+ + KG + + + N+ ++V +G P+ E DL+ + E+ Sbjct: 506 LGLLVLYVVKKGDISFETLKNQS-FEEVIQG-----SPD--EETRDLIHHLFHPGDNVED 557 Query: 509 RPTFEYLQAFLEDYFTSTEPQY 530 R + +F S E +Y Sbjct: 558 RLS----SLLAHPFFWSWESRY 575 >5UU1-A nrPDB Length = 324 Score = 83.9 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 54/300 (18%), Positives = 112/300 (37%), Gaps = 47/300 (15%) Query: 264 EIPRESLRLEVKLGQGCFGEVWMGT-WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRH 322 ++ L K+G G FG +++ N + A +K E + +++ Sbjct: 12 DMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAK 71 Query: 323 EKLVQ---------------LYA-----VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLR 362 + ++ Y ++V E + G L + G+ G + Sbjct: 72 KDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERL--GIDLQKISGQNG-TFK 128 Query: 363 LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVG--ENLVCKVADFGLA-RLIEDNEY 419 ++ + ++ + Y+ YVH D++AAN+L+G +AD+GL+ R + + Sbjct: 129 KSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNGNH 188 Query: 420 TA-----RQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREV 474 R+G I++T+ +A + +SDV G + G++P+ + V Sbjct: 189 KQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLC-GKLPWEQNLKDPV 247 Query: 475 LDQVERGYRM-----------PCPPECPESLHDLMC-QCWRKEPEERPTFEYLQAFLEDY 522 Q + + P C E L+C + E+P ++ L+ L + Sbjct: 248 AVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYD--EKPNYQALKKILNPH 305 >2EYZ-A nrPDB Length = 304 Score = 83.5 bits (205), Expect = 2e-16, Method: Composition-based stats. Identities = 37/150 (24%), Positives = 57/150 (38%), Gaps = 25/150 (16%) Query: 140 VAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKG 199 DS + WY+G+++R+E+ LL G FLVR+S T+ G Y LSVS + Sbjct: 2 AGNFDSEERSSWYWGRLSRQEAVALL--QGQRHGVFLVRDSSTSPGDYVLSVS-----EN 54 Query: 200 LNVKHYKIRK-----------------LDSGGFYITSRTQFNSLQQLVAYYSKHADGLCH 242 V HY I + I + F+SL L+ +Y H Sbjct: 55 SRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQE-FDSLPALLEFYKIHYLDTTT 113 Query: 243 RLTTVCPTSKPQTQGLAKDAWEIPRESLRL 272 + V + + L ++ E R Sbjct: 114 LIEPVSRSRQGSGVILRQEEAEYVRALFDF 143 Score = 70.8 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 23/56 (41%), Positives = 29/56 (51%), Gaps = 1/56 (1%) Query: 87 TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAP 142 AL+D+ E DL FKKG+ L+I + E WW A S G+ G IP YV Sbjct: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAED-SEGKRGMIPVPYVEK 189 >4IX6-A nrPDB Length = 350 Score = 83.1 bits (204), Expect = 3e-16, Method: Composition-based stats. Identities = 46/260 (17%), Positives = 80/260 (30%), Gaps = 63/260 (24%) Query: 260 KDAWEIPRESLR-LEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQ-EAQVM 317 + + + +R L LG G FG V+ G + G V +K K M+ E L+ E V Sbjct: 11 RRTPGVEPKDIRVLPGPLGSGNFGTVFRGVFKGDQDVVLKNAKADVMAAEELLECEMDVN 70 Query: 318 KKLRHEK----LVQLYAVVS--------------EEPIYIVTEYMSKGSLLDFLKGETGK 359 + H + + E +++ + ++ L Sbjct: 71 YHV-HANAKGTCARFMGCIELGAKDGGEIYNGTLTEGLWL-MWANEGENTVEALMRRGTA 128 Query: 360 YLRLPQL----------VDMAAQIASGMAYVERMNYVHRDLRAANILVGE--NLVCKVAD 407 L ++ +A + VHRD++ AN++ E V K+ D Sbjct: 129 PLATAMACADATELGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLID 188 Query: 408 FGLARL---IEDNEYTARQGAKFPIKW--------TAP--------------EAALYGRF 442 G A L + + ++ P EA RF Sbjct: 189 LGAAALCLPLPETLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRF 248 Query: 443 TIKSDVWSFGILLTELTTKG 462 WS G ++ +L G Sbjct: 249 DS----WSAGCVMLQLAVVG 264 >1MIL-A nrPDB Length = 104 Score = 82.3 bits (202), Expect = 5e-16, Method: Composition-based stats. Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 11/113 (9%) Query: 144 DSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVK 203 ++ E W+ GK++RRE+E LL G FLVRES TT G Y L+ K L + Sbjct: 2 SQLRGEPWFHGKLSRREAEALL----QLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLL- 56 Query: 204 HYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQ 256 +D G T +F S+ L++Y+ + + + +C + + Sbjct: 57 ------VDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERK 103 >2PLE-A nrPDB Length = 105 Score = 80.8 bits (198), Expect = 1e-15, Method: Composition-based stats. Identities = 26/101 (25%), Positives = 49/101 (48%), Gaps = 9/101 (8%) Query: 147 QAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYK 206 +++EWY +TR ++E +L+ G FLVR+ +Y +S +KH + Sbjct: 7 ESKEWYHASLTRAQAEHMLMRVPR-DGAFLVRKR-NEPNSYAISFRA-----EGKIKHCR 59 Query: 207 IRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTV 247 +++ G + ++F+SL L++YY KH +L Sbjct: 60 VQQ--EGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYP 98 >2EOB-A nrPDB Length = 124 Score = 80.0 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 31/109 (28%), Positives = 53/109 (48%), Gaps = 8/109 (7%) Query: 142 PSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLN 201 + +++ WY+ +++R E+E +L+ G FL+R+ E T +Y ++ Sbjct: 12 NPNPHESKPWYYDRLSRGEAEDMLMRIPR-DGAFLIRKREGT-DSYAITFRAR-----GK 64 Query: 202 VKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPT 250 VKH +I + D F + + F SL +LV+YY KHA RL Sbjct: 65 VKHCRINR-DGRHFVLGTSAYFESLVELVSYYEKHALYRKMRLRYPVTP 112 >3JV3-A nrPDB Length = 283 Score = 80.0 bits (196), Expect = 3e-15, Method: Composition-based stats. Identities = 21/68 (30%), Positives = 39/68 (57%), Gaps = 3/68 (4%) Query: 85 GVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSD 144 G + +YDY ++ + +L+F KG+ + ++N + DWW +GQ G PSNYV + Sbjct: 1 GSCQVIGMYDYTAQNDDELAFSKGQIINVLNKEDPDWWKGE--VSGQVGLFPSNYVKLTT 58 Query: 145 SIQ-AEEW 151 + +++W Sbjct: 59 DMDPSQQW 66 >5DMZ-A nrPDB Length = 365 Score = 79.6 bits (195), Expect = 3e-15, Method: Composition-based stats. Identities = 50/319 (15%), Positives = 106/319 (33%), Gaps = 43/319 (13%) Query: 239 GLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKL-------GQGCFGEVWMGT--- 288 L L+ + + K P+ +L KL G+G F +V+ T Sbjct: 29 KLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGD 88 Query: 289 ---WNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR----HEKLVQLYAV-VSEEPIYIV 340 + +K KP +P F Q+M++L+ H ++ Y+ + + +V Sbjct: 89 LNDAKNKQKFVLKVQKPA--NPWEFYIGTQLMERLKPSMQHMF-MKFYSAHLFQNGSVLV 145 Query: 341 TEYMSKGSLLDFL---KGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILV 397 E S G+LL+ + K K + ++ A ++ + V +H D++ N ++ Sbjct: 146 GELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFIL 205 Query: 398 GENLV-----------CKVADFGLARLIE-DNEYTARQGAKFPIKWTAPEAALYGRFTIK 445 G + + D G + ++ + T + E + + Sbjct: 206 GNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQ 265 Query: 446 SDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCP-PECPESLHDLMCQCWRK 504 D + + + + V E + G P + +M Sbjct: 266 IDYFGVAATVYCMLFGTYM----KVKNEGGECKPEGLFRRLPHLDMWNEFFHVMLNI--P 319 Query: 505 EPEERPTFEYLQAFLEDYF 523 + P+ + L+ L+ F Sbjct: 320 DCHHLPSLDLLRQKLKKVF 338 >4JGH-A nrPDB Length = 173 Score = 78.9 bits (193), Expect = 5e-15, Method: Composition-based stats. Identities = 26/84 (30%), Positives = 43/84 (51%), Gaps = 3/84 (3%) Query: 151 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR-K 209 WY+G +T E++ L E P GTFL+R+S + +SV L +++ + + Sbjct: 23 WYWGSMTVNEAKEKL--KEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFR 80 Query: 210 LDSGGFYITSRTQFNSLQQLVAYY 233 LDS + QF+S+ L+ YY Sbjct: 81 LDSIICVKSKLKQFDSVVHLIDYY 104 >3GF9-A nrPDB Length = 295 Score = 77.0 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 25/66 (37%), Positives = 38/66 (57%), Gaps = 3/66 (4%) Query: 87 TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYV-APSDS 145 +A+YDY + E +LSF KG+ + ++N + DWW G TG PSNYV +DS Sbjct: 19 CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGE--INGVTGLFPSNYVKMTTDS 76 Query: 146 IQAEEW 151 +++W Sbjct: 77 DPSQQW 82 >1GCQ-A nrPDB Length = 61 Score = 75.8 bits (185), Expect = 4e-14, Method: Composition-based stats. Identities = 20/60 (33%), Positives = 37/60 (61%), Gaps = 2/60 (3%) Query: 85 GVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSD 144 G T AL+D++ + + +L F++G+ + +++N++ +WW GQTG P NYV P + Sbjct: 1 GSTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGA--CHGQTGMFPRNYVTPVN 58 >2X3W-D nrPDB Length = 60 Score = 74.3 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 20/54 (37%), Positives = 29/54 (53%) Query: 88 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVA 141 ALYDY+ + + +LSFK G+ L + + W L +GQ G P+NYV Sbjct: 5 RVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVE 58 >2JII-A nrPDB Length = 352 Score = 74.3 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 37/213 (17%), Positives = 81/213 (38%), Gaps = 20/213 (9%) Query: 329 YAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 + V ++ ++V + SL L L ++ +A ++ + ++ YVH Sbjct: 125 FGVHQDKYRFLVLPSL-GRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHG 183 Query: 389 DLRAANILVG--ENLVCKVADFGLA-RLIEDNEYT-----ARQGAKFPIKWTAPEAALYG 440 ++ A NI V + +A +G A R ++ +R + +++ + + Sbjct: 184 NVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGC 243 Query: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGM--VNREVLDQVERGYRMPCP--PEC------ 490 + +SD+ S G + G +P+ +++ Q ++ P P C Sbjct: 244 GPSRRSDLQSLGYCML-KWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRP 302 Query: 491 PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 E+L + EE+P + L+ LE Sbjct: 303 SETLQKYLKVVMALTYEEKPPYAMLRNNLEALL 335 >6F55-A nrPDB Length = 67 Score = 73.5 bits (179), Expect = 2e-13, Method: Composition-based stats. Identities = 21/56 (37%), Positives = 27/56 (48%) Query: 88 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPS 143 ALYDY + +LSFK GE L ++ + W L TG G P+NYV Sbjct: 7 RVRALYDYTGQEADELSFKAGEELMKISEEDEQGWCKGRLLTGHVGLYPANYVEKV 62 >1GBQ-A nrPDB Length = 74 Score = 71.9 bits (175), Expect = 7e-13, Method: Composition-based stats. Identities = 19/57 (33%), Positives = 33/57 (57%), Gaps = 1/57 (1%) Query: 85 GVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVA 141 G +A YD+++ + +LSFK+G+ L+++N W L G+ G+IP NY+ Sbjct: 8 GSMEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAEL-NGKDGFIPKNYIE 63 >3EHQ-A nrPDB Length = 222 Score = 71.6 bits (174), Expect = 8e-13, Method: Composition-based stats. Identities = 25/62 (40%), Positives = 36/62 (58%), Gaps = 2/62 (3%) Query: 84 GGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPS 143 G V F ALY +E RT +L ++G+ + I + ++ +WW S G+TG IPSNYVA Sbjct: 12 GQVKVFRALYTFEPRTPDELYIEEGDIIYITDMSDTNWWKG--TSKGRTGLIPSNYVAEQ 69 Query: 144 DS 145 Sbjct: 70 AE 71 >1KA6-A nrPDB Length = 128 Score = 71.6 bits (174), Expect = 9e-13, Method: Composition-based stats. Identities = 28/121 (23%), Positives = 51/121 (42%), Gaps = 11/121 (9%) Query: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205 + A Y GKI+R E+LLL A G++L+R+SE+ G YCL V + Y Sbjct: 1 MDAVAVYHGKISRETGEKLLL-ATGLDGSYLLRDSESVPGVYCLCVL-----YHGYIYTY 54 Query: 206 KIRKLDSGGFYITS-----RTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAK 260 ++ + ++G + + + F ++ L++ + K G+ L Sbjct: 55 RVSQTETGSWSAETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEKKSSARSTQGT 114 Query: 261 D 261 Sbjct: 115 T 115 >2V1Q-A nrPDB Length = 60 Score = 71.2 bits (173), Expect = 1e-12, Method: Composition-based stats. Identities = 14/60 (23%), Positives = 38/60 (63%), Gaps = 1/60 (1%) Query: 85 GVTTFVALYDYESRTETDLSFKKGERLQIVNNTEG-DWWLAHSLSTGQTGYIPSNYVAPS 143 G+ + YD+ + ++ +L+ K G+++ I+++ + DWW+ + +G++G +P+ ++ P Sbjct: 1 GMERGIVQYDFMAESQDELTIKSGDKVYILDDKKSKDWWMCQLVDSGKSGLVPAQFIEPV 60 >1M27-A nrPDB Length = 104 Score = 70.4 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 28/110 (25%), Positives = 51/110 (46%), Gaps = 11/110 (10%) Query: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205 + A Y GKI+R E+LLL A G++L+R+SE+ G YCL V + Y Sbjct: 1 MDAVAVYHGKISRETGEKLLL-ATGLDGSYLLRDSESVPGVYCLCVL-----YHGYIYTY 54 Query: 206 KIRKLDSGGFYITS-----RTQFNSLQQLVAYYSKHADGLCHRLTTVCPT 250 ++ + ++G + + + F ++ L++ + K G+ L Sbjct: 55 RVSQTETGSWSAETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVEK 104 >5NP2-A nrPDB Length = 61 Score = 70.4 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 24/60 (40%), Positives = 38/60 (63%), Gaps = 3/60 (5%) Query: 86 VTTFVALYDYESRTETDLSFKKGERLQIVN-NTEGDWWLAHSLSTGQTGYIPSNYVAPSD 144 + FVALYD+ + + LS KGE+L+++ N G+W A + GQ G++PSNY+ P + Sbjct: 4 MNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQT-KNGQ-GWVPSNYITPVN 61 >1UEC-A nrPDB Length = 193 Score = 70.4 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 19/72 (26%), Positives = 39/72 (54%), Gaps = 4/72 (5%) Query: 79 AGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSN 138 GP+ + T+ A+ DYE + ++++ G+ +++V +E WW + G+IP++ Sbjct: 6 TGPII--LQTYRAIADYEKTSGSEMALSTGDVVEVVEKSESGWWFCQ--MKAKRGWIPAS 61 Query: 139 YVAPSDSIQAEE 150 ++ P DS E Sbjct: 62 FLEPLDSPDETE 73 Score = 48.4 bits (114), Expect = 7e-06, Method: Composition-based stats. Identities = 26/138 (18%), Positives = 46/138 (33%), Gaps = 6/138 (4%) Query: 13 QRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDT 72 Q R++ E G+ S G +S D Sbjct: 12 QTYRAIADYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDE 71 Query: 73 VTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQT 132 P+ P G +VA+ Y + ++S +GE +++++ WW+ T Sbjct: 72 TEDPE---PNYAG-EPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDV--T 125 Query: 133 GYIPSNYVAPSDSIQAEE 150 GY PS Y+ S ++ Sbjct: 126 GYFPSMYLQKSGQDVSQA 143 >2CUC-A nrPDB Length = 70 Score = 70.4 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 22/66 (33%), Positives = 33/66 (50%) Query: 80 GPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNY 139 G FVAL+ Y + +L +KGE ++++ + W SL TG+TG PS+Y Sbjct: 1 GSSGSSGNMFVALHTYSAHRPEELDLQKGEGIRVLGKYQDGWLKGLSLLTGRTGIFPSDY 60 Query: 140 VAPSDS 145 V P Sbjct: 61 VIPVSG 66 >6G4J-A nrPDB Length = 315 Score = 69.6 bits (169), Expect = 3e-12, Method: Composition-based stats. Identities = 27/154 (17%), Positives = 60/154 (38%), Gaps = 22/154 (14%) Query: 268 ESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQ 327 + L +LG+G G V++ VA+K + + E V+K + V Sbjct: 26 NTYTLRKQLGKGANGIVYLAE-TSDGHVALKV----SDDSLSITSEVNVLKSFSKAQSVT 80 Query: 328 LY-AVVSEEPIYI----------VTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376 + + + YI EY+ LL ++ + +++ + + Q+ S Sbjct: 81 MGPSFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGAEWIPV-----LMIQLLSS 135 Query: 377 MAYVERMNYVHRDLRAANILVGE-NLVCKVADFG 409 ++ + + ++ DL+ N++V + D G Sbjct: 136 LSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVG 169 >2CUD-A nrPDB Length = 79 Score = 69.2 bits (168), Expect = 4e-12, Method: Composition-based stats. Identities = 30/75 (40%), Positives = 43/75 (57%), Gaps = 5/75 (6%) Query: 75 SPQRAGPLA---GGVTTFVA-LYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTG 130 S +GPL G + F+A L DY S + F++GE+L+++++ EG WW A SLSTG Sbjct: 2 SSGSSGPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISD-EGGWWKAISLSTG 60 Query: 131 QTGYIPSNYVAPSDS 145 + YIP VA Sbjct: 61 RESYIPGICVARVSG 75 >2JT4-A nrPDB Length = 71 Score = 69.2 bits (168), Expect = 4e-12, Method: Composition-based stats. Identities = 14/65 (21%), Positives = 38/65 (58%), Gaps = 1/65 (1%) Query: 87 TTFVALYDYESRTETDLSFKKGERLQIVNNTEG-DWWLAHSLSTGQTGYIPSNYVAPSDS 145 + YD+ + ++ +L+ K G+++ I+++ + DWW+ + +G++G +P+ ++ P Sbjct: 7 KRGIVQYDFMAESQDELTIKSGDKVYILDDKKSKDWWMCQLVDSGKSGLVPAQFIEPVRD 66 Query: 146 IQAEE 150 + E Sbjct: 67 KKHTE 71 >6EWX-A nrPDB Length = 484 Score = 68.9 bits (167), Expect = 5e-12, Method: Composition-based stats. Identities = 41/252 (16%), Positives = 84/252 (33%), Gaps = 57/252 (22%) Query: 333 SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQL-----VDMAAQIASGMAYVERMNYVH 387 ++ + ++T + + DF++ + P++ + Q+ +G+ +++ +H Sbjct: 174 EQDCVVVITREVPHQTASDFVRDSVASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIH 233 Query: 388 RDLRAANILV---------------------------------------GENLVCK--VA 406 RDL N+L+ GE + + ++ Sbjct: 234 RDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCPSAAPAATTACQGGPGEKHLPRLIIS 293 Query: 407 DFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPY 466 +F A+ +Q K APE ++ K D + GIL+ EL P Sbjct: 294 NFLKAKQKPGGTTNLQQ--KKSQARLAPEIVSASQY-RKFDEFQTGILIYELL---HQPN 347 Query: 467 PGMVNREVLDQVERGYRMPCPPEC---PESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 523 P V ++ ++ R +P P L L +P +R + L+ Sbjct: 348 PFEVRAQLRERDYRREDLPPLPTLSLYSPGLQQLAHLLLEADPIKRIRIGEAKRVLQCLL 407 Query: 524 TSTEPQY--QPG 533 + QP Sbjct: 408 WGPRRELVEQPC 419 >1OV3-A nrPDB Length = 138 Score = 68.5 bits (166), Expect = 6e-12, Method: Composition-based stats. Identities = 17/65 (26%), Positives = 36/65 (55%), Gaps = 2/65 (3%) Query: 86 VTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDS 145 + T+ A+ DYE + ++++ G+ +++V +E WW + G+IP++++ P DS Sbjct: 11 LQTYRAIADYEKTSGSEMALSTGDVVEVVEKSESGWWFCQ--MKAKRGWIPASFLEPLDS 68 Query: 146 IQAEE 150 E Sbjct: 69 PDETE 73 Score = 47.3 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 26/131 (19%), Positives = 44/131 (33%), Gaps = 6/131 (4%) Query: 13 QRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDT 72 Q R++ E G+ S G +S D Sbjct: 12 QTYRAIADYEKTSGSEMALSTGDVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDE 71 Query: 73 VTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQT 132 P+ P G +VA+ Y + ++S +GE +++++ WW+ T Sbjct: 72 TEDPE---PNYAG-EPYVAIKAYTAVEGDEVSLLEGEAVEVIHKLLDGWWVIRKDDV--T 125 Query: 133 GYIPSNYVAPS 143 GY PS Y+ S Sbjct: 126 GYFPSMYLQKS 136 >4OAU-C nrPDB Length = 699 Score = 68.5 bits (166), Expect = 6e-12, Method: Composition-based stats. Identities = 50/255 (19%), Positives = 94/255 (36%), Gaps = 44/255 (17%) Query: 282 GEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLR-HEKLVQLYAVVSEEPIYIV 340 G +++G + VA+KT G+ + +E ++ R + LV Y S V Sbjct: 357 GGIYLGFY-EKQEVAVKTFCEGSPRAQ---REVSCLQSSRENSHLVTFYGSESHRGHLFV 412 Query: 341 TEYMSKGSL---LDFLKGETGKYLRLPQLVDMAAQIASGMAYVE-RMNYVHRDLRAANIL 396 + + +L LD +GE + ++ + I + + Y H+DL+ NIL Sbjct: 413 CVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNIL 472 Query: 397 VGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLT 456 + +ADF + IKW +K D+ G L+ Sbjct: 473 IDSKKAAHLADFDKS-----------------IKW------AGDPQEVKRDLEDLGRLVL 509 Query: 457 ELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQ 516 + KG + + + + + V+ P+ E DL+ + + R + L Sbjct: 510 YVVKKGSISFEDLKAQSNEEVVQ------LSPD--EETKDLIHRLFHPGEHVR---DCLS 558 Query: 517 AFL-EDYFTSTEPQY 530 L +F + E +Y Sbjct: 559 DLLGHPFFWTWESRY 573 >3QWY-A nrPDB Length = 308 Score = 68.5 bits (166), Expect = 7e-12, Method: Composition-based stats. Identities = 30/115 (26%), Positives = 47/115 (40%), Gaps = 4/115 (3%) Query: 33 PASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVAL 92 + +A G + + +F P L F + A + V Sbjct: 97 ERGEPKEDGTAAAGVKIANQSFPDI---PALLNHFKMRVLTEASLLAAYKKPIIEVVVGT 153 Query: 93 YDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQ 147 + + ETDL F++GERL+I++ T DWW A + G TG +P+NYV Sbjct: 154 FKFTGERETDLPFEQGERLEILSKTNQDWWEARNAL-GTTGLVPANYVQIQMEFH 207 Score = 63.9 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 26/103 (25%), Positives = 46/103 (44%), Gaps = 12/103 (11%) Query: 141 APSDSIQAEEW---YFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNA 197 ++ EW YF ++R E+ +LL + GTFL+R+S + G Y L+V + D Sbjct: 30 MTTNGFDPFEWRSFYFPGMSREEAHKLLGEPQVSIGTFLMRDS-SRPGEYSLTVREAD-- 86 Query: 198 KGLNVKHYKIRKLDSGG------FYITSRTQFNSLQQLVAYYS 234 +G V HY I + + + F + L+ ++ Sbjct: 87 EGNAVCHYLIERGEPKEDGTAAAGVKIANQSFPDIPALLNHFK 129 >4N78-F nrPDB Length = 514 Score = 68.5 bits (166), Expect = 8e-12, Method: Composition-based stats. Identities = 18/57 (31%), Positives = 29/57 (50%), Gaps = 2/57 (3%) Query: 86 VTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAP 142 + VA+YDY E +LSF++G + ++ + W+ + G TG P NYV Sbjct: 454 LEKVVAIYDYTKDKEDELSFQEGAIIYVIKKNDDGWYEG--VMNGVTGLFPGNYVES 508 >2ED0-A nrPDB Length = 78 Score = 68.1 bits (165), Expect = 8e-12, Method: Composition-based stats. Identities = 20/75 (26%), Positives = 31/75 (41%), Gaps = 6/75 (8%) Query: 75 SPQRAGPLAGGV----TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTG 130 S +G VA+YDY E +LSF++G + ++ + W+ + G Sbjct: 2 SSGSSGDPPWAPRSYLEKVVAIYDYTKDKEDELSFQEGAIIYVIKKNDDGWYEG--VMNG 59 Query: 131 QTGYIPSNYVAPSDS 145 TG P NYV Sbjct: 60 VTGLFPGNYVESISG 74 >6M7Z-A nrPDB Length = 319 Score = 67.7 bits (164), Expect = 1e-11, Method: Composition-based stats. Identities = 46/239 (19%), Positives = 83/239 (34%), Gaps = 40/239 (16%) Query: 295 VAIKTLKPGTMSPEAFLQEAQVMKKL---RHEKLVQLYAVVSEEPIYIVTEYMSKGSLLD 351 V+ K + P+ + E + +++ R L+ + + +SKG + D Sbjct: 76 VSAKVRLINLLDPKYSVYEPYLYREILPKRSPLLLPSLGEYRGAFLTYIFHPLSKGLVGD 135 Query: 352 FLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLA 411 L+ P + +AA + + + + + +HR + + V + + GL Sbjct: 136 MLETGR----SHPDVQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDGTVVLG--GLD 189 Query: 412 RLIEDNEYTARQGAKFPIKWTAPEA---------ALYGRFTIKSDVWSFGILLTELTTKG 462 T F + TAPE GR T+KSDV+S G+ Sbjct: 190 TAAPIGTETRLWVGFFGQE-TAPEIDRNFLADLALTQGRHTVKSDVYSLGVAF------- 241 Query: 463 RVPYPGMVNREVLDQVERGYRMP-----CPPECPESLHDLMCQCWRKEPEERPTFEYLQ 516 R ++ + G P + E L L + +EP RPT E + Sbjct: 242 ---------RNLVQLLGNGNLGPEDRGAVRQDHLELLDKLSQKMIEEEPGNRPTIEEIM 291 >2YUP-A nrPDB Length = 90 Score = 66.5 bits (161), Expect = 3e-11, Method: Composition-based stats. Identities = 21/75 (28%), Positives = 35/75 (46%), Gaps = 4/75 (5%) Query: 75 SPQRAG--PLAGGVTT--FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTG 130 S +G P + VA Y ++ E +LSF+KGE + ++ +W+ TG Sbjct: 2 SSGSSGKPPTYQVLEYGEAVAQYTFKGDLEVELSFRKGEHICLIRKVNENWYEGRITGTG 61 Query: 131 QTGYIPSNYVAPSDS 145 + G P++YV S Sbjct: 62 RQGIFPASYVQVSRE 76 >4CI6-B nrPDB Length = 643 Score = 65.4 bits (158), Expect = 6e-11, Method: Composition-based stats. Identities = 45/277 (16%), Positives = 92/277 (33%), Gaps = 46/277 (16%) Query: 290 NGTTRVAIKTLKPGTMSPEAFLQEAQVMKKL-----RHEKLVQLYA--VVSEEPIY---I 339 R+ K + +++ E + K + +H L ++ VV Y + Sbjct: 66 KDKQRLVAKIER--SIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYYYAL 123 Query: 340 VTEYMSKGSLLDFLKGETGKYLR--------LPQLVDMAAQIASGMAYVERMNYVHRDLR 391 + + + D L+ + + + +A ++ ++ + VH D++ Sbjct: 124 LMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDIK 183 Query: 392 AANILVGE-NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYG-RFTIKSDVW 449 N++ + V D GL + + Q F + APE + + KSDV+ Sbjct: 184 PGNVVFDRASGEPVVIDLGL------HSRSGEQPKGFTESFKAPELGVGNLGASEKSDVF 237 Query: 450 SFGILLTELT--TKGRVPYPGMVNREVLDQV---------ERGYRMPCP--PECPESLHD 496 ++++ L +G P + + L + E GY + P + Sbjct: 238 ---LVVSTLLHGIEGFEKDPEIKPNQGLRFITSEPAHVMDENGYPIHRPGIAGVETAYTR 294 Query: 497 LMCQCWRKEPEERPTFEY--LQAFLEDYFTSTEPQYQ 531 + + RP L FL D E Q Sbjct: 295 FITDILGVSADSRPDSNEARLHEFLSDGTIDEESAKQ 331 >2VIF-A nrPDB Length = 141 Score = 63.9 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 24/96 (25%), Positives = 38/96 (39%), Gaps = 11/96 (11%) Query: 140 VAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKG 199 + + WY+G ITR E+E L N P G+FLVR+S + LS Sbjct: 15 TEELKKLAKQGWYWGPITRWEAEGKLANV--PDGSFLVRDSSDDRYLLSLSFRSHGKTLH 72 Query: 200 LNVKHYKIRKLDSGGFYITSR---TQFNSLQQLVAY 232 ++H +G F + S+ L+ + Sbjct: 73 TRIEH------SNGRFSFYEQPDVEGHTSIVDLIEH 102 >6BHC-A nrPDB Length = 438 Score = 63.5 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 47/276 (17%), Positives = 88/276 (31%), Gaps = 52/276 (18%) Query: 295 VAIKTLKPGTMSPEAFLQEAQVMKKL-RHEKL------------VQLYAVVS-----EEP 336 A+K K + + V + L H + +L Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPSKKQRSH 145 Query: 337 IYIVTEYMSKGSLLDFLKGETGKY-----LRLPQLVDMAAQIASGMAYVERMNYVHRDLR 391 + ++T + ++ DF++ ++ L Q+ + Q+ SG+ +++ + H DLR Sbjct: 146 VVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLR 205 Query: 392 AANILVGE---NLVCKVADFGLARLIEDNEYTARQGAKFPIK-----------------W 431 N+L+ + FG A + Y R + Sbjct: 206 LENLLLVHYQPGGTAQ--GFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSR 263 Query: 432 TAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPE-- 489 APE ++ K D + GIL+ E+ +P P N E+ ++ +P P Sbjct: 264 LAPEIITATQY-KKCDEFQTGILIYEML---HLPNPFDENPELKEREYTRADLPRIPFRS 319 Query: 490 -CPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFT 524 L L P ER + L+ Sbjct: 320 PYSRGLQQLASCLLNPNPSERILISDAKGILQCLLW 355 >2CS0-A nrPDB Length = 119 Score = 63.1 bits (152), Expect = 3e-10, Method: Composition-based stats. Identities = 28/89 (31%), Positives = 43/89 (48%), Gaps = 9/89 (10%) Query: 150 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRK 209 EW+ G I+R ++E LL P G+FL+R S + G Y LS + H+ ++ Sbjct: 17 EWFHGAISREDAENLL--ESQPLGSFLIRVSHSHVG-YTLSYKAQSSCC-----HFMVKL 68 Query: 210 LDSGGFYIT-SRTQFNSLQQLVAYYSKHA 237 LD G F I + SL LV ++ + Sbjct: 69 LDDGTFMIPGEKVAHTSLDALVTFHQQKP 97 >1XA6-A nrPDB Length = 466 Score = 63.1 bits (152), Expect = 3e-10, Method: Composition-based stats. Identities = 29/165 (17%), Positives = 53/165 (32%), Gaps = 21/165 (12%) Query: 115 NNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWY----FGKITRRESERLLLNAEN 170 + W ++ Q P + P + ++Y G I+R +++ LL Sbjct: 17 EEYQPPIWKSYLYQLQQEAPRPKRIICPREVENRPKYYGREFHGIISREQADELL---GG 73 Query: 171 PRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLV 230 G +++RES+ G Y L++ + + H G ++ +F S+ LV Sbjct: 74 VEGAYILRESQRQPGCYTLALRFGNQTLNYRLFH-------DGKHFVGE-KRFESIHDLV 125 Query: 231 AYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVK 275 DGL I +L E Sbjct: 126 ------TDGLITLYIETKAAEYISKMTTNPIYEHIGYATLLREKV 164 >3CXL-A nrPDB Length = 463 Score = 61.5 bits (148), Expect = 8e-10, Method: Composition-based stats. Identities = 24/122 (19%), Positives = 46/122 (37%), Gaps = 17/122 (13%) Query: 152 YFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLD 211 + G I+R +++LL+ A G++L+RES+ G Y L++ + + + Sbjct: 54 FHGMISREAADQLLIVA---EGSYLIRESQRQPGTYTLALRFGSQTRNFRLYY------- 103 Query: 212 SGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLR 271 G ++ +F S+ LV DGL + + +L Sbjct: 104 DGKHFVGE-KRFESIHDLV------TDGLITLYIETKAAEYIAKMTINPIYEHVGYTTLN 156 Query: 272 LE 273 E Sbjct: 157 RE 158 >1X69-A nrPDB Length = 79 Score = 61.5 bits (148), Expect = 8e-10, Method: Composition-based stats. Identities = 19/75 (25%), Positives = 33/75 (44%), Gaps = 3/75 (4%) Query: 72 TVTSPQRAGPLAGGV-TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTG 130 + S + T VALYDY++ + ++SF + + + + WW + G Sbjct: 2 SSGSSGTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWW--RGVCKG 59 Query: 131 QTGYIPSNYVAPSDS 145 + G P+NYV S Sbjct: 60 RYGLFPANYVELRQS 74 >5NXJ-A nrPDB Length = 60 Score = 60.8 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 16/57 (28%), Positives = 29/57 (50%), Gaps = 2/57 (3%) Query: 88 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSD 144 T +ALYDY++ + ++SF + + + + WW + G+ G P+NYV Sbjct: 6 TAIALYDYQAAGDDEISFDPDDIITNIEMIDDGWW--RGVCKGRYGLFPANYVELRQ 60 >3ULR-B nrPDB Length = 65 Score = 60.8 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 16/57 (28%), Positives = 29/57 (50%), Gaps = 2/57 (3%) Query: 88 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSD 144 T +ALYDY++ + ++SF + + + + WW + G+ G P+NYV Sbjct: 11 TAIALYDYQAAGDDEISFDPDDIITNIEMIDDGWW--RGVCKGRYGLFPANYVELRQ 65 >2KBT-A nrPDB Length = 142 Score = 60.4 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 21/60 (35%), Positives = 33/60 (55%), Gaps = 3/60 (5%) Query: 83 AGGVTTFVALYDYESRTETDLSFKKGERLQIVNNT-EGDWWLAHSLSTGQTGYIPSNYVA 141 G T A YD+ +R ++LS K+G+ ++I+N + WW G+ G+ PSNYV Sbjct: 2 PGTFGTAKARYDFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIY--GRIGWFPSNYVE 59 >2HDV-A nrPDB Length = 111 Score = 60.0 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 24/101 (23%), Positives = 43/101 (42%), Gaps = 7/101 (6%) Query: 141 APSDSIQAEEWYFGKITRRESERL-LLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKG 199 + W+ G ++R ++ +L L G FLVR+SET +G L+ + AK Sbjct: 1 GSDQPLSGYPWFHGMLSRLKAAQLVLEGGTGSHGVFLVRQSETRRGECVLTFNFQGKAKH 60 Query: 200 LNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL 240 L + L++ G F S+ ++ ++ H L Sbjct: 61 LRL------SLNAAGQCRVQHLHFQSIFDMLEHFRVHPIPL 95 >5VEI-A nrPDB Length = 110 Score = 60.0 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 17/55 (30%), Positives = 31/55 (56%), Gaps = 2/55 (3%) Query: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDS 145 A+YD++++T +LSFKKG+ + I+ + +W+ G+ G P +YV Sbjct: 39 AVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEH--HGRVGIFPISYVEKLTG 91 >1UHF-A nrPDB Length = 69 Score = 60.0 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 23/59 (38%), Positives = 33/59 (55%), Gaps = 3/59 (5%) Query: 87 TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDS 145 ++ALY Y S DL+F +GE + +V +G+WW ++G PSNYV P DS Sbjct: 9 EEYIALYPYSSVEPGDLTFTEGEEI-LVTQKDGEWWTGSIGD--RSGIFPSNYVKPKDS 64 >2O2O-A nrPDB Length = 92 Score = 59.6 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 15/67 (22%), Positives = 27/67 (40%), Gaps = 2/67 (2%) Query: 83 AGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAP 142 + Y + + +L K G+ +++V E WW + G+TG PSN++ Sbjct: 15 ERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEG--VLNGKTGMFPSNFIKE 72 Query: 143 SDSIQAE 149 E Sbjct: 73 LSGESDE 79 >1WI7-A nrPDB Length = 68 Score = 58.8 bits (141), Expect = 5e-09, Method: Composition-based stats. Identities = 15/66 (22%), Positives = 27/66 (40%), Gaps = 2/66 (3%) Query: 80 GPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNY 139 G + Y + + +L K G+ +++V E WW + G+TG PSN+ Sbjct: 1 GSSGSSGRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEG--VLNGKTGMFPSNF 58 Query: 140 VAPSDS 145 + Sbjct: 59 IKELSG 64 >5XHZ-A nrPDB Length = 66 Score = 58.5 bits (140), Expect = 8e-09, Method: Composition-based stats. Identities = 14/58 (24%), Positives = 26/58 (44%), Gaps = 2/58 (3%) Query: 88 TFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDS 145 + Y + + +L K G+ +++V E WW + G+TG PSN++ Sbjct: 11 RCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEG--VLNGKTGMFPSNFIKELSG 66 >6C7Y-B nrPDB Length = 117 Score = 57.7 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 21/89 (23%), Positives = 39/89 (43%), Gaps = 9/89 (10%) Query: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205 + A +Y+G +T + L P GTFL+R+S + +SV + + Sbjct: 23 LDACGFYWGPLTVSAAHEKL--KSEPEGTFLIRDSTQKNCFFAISVKTATGPTSIRI--- 77 Query: 206 KIRKLDSGGFYI-TSRTQFNSLQQLVAYY 233 +G F + S+ F+ L +L+ +Y Sbjct: 78 ---NFQTGRFSLDGSKETFDCLFKLLEHY 103 >5O2M-A nrPDB Length = 81 Score = 57.7 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 16/62 (25%), Positives = 29/62 (46%), Gaps = 5/62 (8%) Query: 91 ALYDYESRTETDLSFKKGERLQIVNNTE---GDWWLAHSLSTGQTGYIPSNYVAPSDSIQ 147 ALYD + + +LSF+KG+ + ++ WWL G+ G +P N + + Sbjct: 12 ALYDNVAESPDELSFRKGDIMTVLERDTQGLDGWWLC--SLHGRQGIVPGNRLKILVGMY 69 Query: 148 AE 149 + Sbjct: 70 DK 71 >6C5X-D nrPDB Length = 164 Score = 57.3 bits (137), Expect = 1e-08, Method: Composition-based stats. Identities = 23/103 (22%), Positives = 41/103 (39%), Gaps = 9/103 (8%) Query: 140 VAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKG 199 S + +Y+G + + L P GTFL+R+S+ + +SV Sbjct: 21 TKTSSMLDTCGFYWGPMDVNVAHDKL--KSEPIGTFLIRDSKQKNCFFAISVKTARETVS 78 Query: 200 LNVKHYKIRKLDSGGFYI-TSRTQFNSLQQLVAYYSKHADGLC 241 + +K +G F + S+ F+ L QLV +Y + Sbjct: 79 IRIK------FHAGKFSLDGSKELFSCLFQLVEHYMTSPKKML 115 >4GL9-E nrPDB Length = 143 Score = 57.3 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 27/109 (24%), Positives = 46/109 (42%), Gaps = 15/109 (13%) Query: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205 +Q +Y+ +T E+ LL P GTFL+R+S + + LSV K L + Sbjct: 25 LQESGFYWSAVTGGEANLLLSAE--PAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRI--- 79 Query: 206 KIRKLDSGGFYITSR-------TQFNSLQQLVAYYSKHADGLCHRLTTV 247 + + G F + S +F+ + +LV +Y G R + Sbjct: 80 ---QCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMGSGSGSGSRAYYI 125 >5O2Q-A nrPDB Length = 99 Score = 56.9 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 16/62 (25%), Positives = 29/62 (46%), Gaps = 5/62 (8%) Query: 91 ALYDYESRTETDLSFKKGERLQIVNNTE---GDWWLAHSLSTGQTGYIPSNYVAPSDSIQ 147 ALYD + + +LSF+KG+ + ++ WWL G+ G +P N + + Sbjct: 12 ALYDNVAESPDELSFRKGDIMTVLERDTQGLDGWWLC--SLHGRQGIVPGNRLKILVGMY 69 Query: 148 AE 149 + Sbjct: 70 DK 71 >5O2P-A nrPDB Length = 100 Score = 56.9 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 16/62 (25%), Positives = 29/62 (46%), Gaps = 5/62 (8%) Query: 91 ALYDYESRTETDLSFKKGERLQIVNNTE---GDWWLAHSLSTGQTGYIPSNYVAPSDSIQ 147 ALYD + + +LSF+KG+ + ++ WWL G+ G +P N + + Sbjct: 12 ALYDNVAESPDELSFRKGDIMTVLERDTQGLDGWWLC--SLHGRQGIVPGNRLKILVGMY 69 Query: 148 AE 149 + Sbjct: 70 DK 71 >1RPY-A nrPDB Length = 114 Score = 56.9 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 22/97 (22%), Positives = 42/97 (43%), Gaps = 7/97 (7%) Query: 145 SIQAEEWYFGKITRRESERLLLNAE-NPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVK 203 + W+ G ++R ++ +L+L G F++R+SET G L+ + AK L + Sbjct: 7 ELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRL- 65 Query: 204 HYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL 240 L+ G F S+ ++ ++ H L Sbjct: 66 -----SLNGHGQCHVQHLWFQSVFDMLRHFHTHPIPL 97 >2PZ1-A nrPDB Length = 466 Score = 56.5 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 20/84 (23%), Positives = 38/84 (45%), Gaps = 10/84 (11%) Query: 65 GGFNSSDTVTSPQRAGP--------LAGGVTTFVALYDYESRTETDLSFKKGERLQIVNN 116 G +SS + P G G V AL+D+ + + +L FK G+ +++++ Sbjct: 1 GAMSSSHHYSHPGGGGEQLAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDA 60 Query: 117 TEGDWWLAHSLSTGQTGYIPSNYV 140 T +WW G+ P+++V Sbjct: 61 TNREWWWGRVAD--GEGWFPASFV 82 >2DA9-A nrPDB Length = 70 Score = 56.1 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 14/68 (20%), Positives = 29/68 (42%), Gaps = 4/68 (5%) Query: 80 GPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNT--EGDWWLAHSLSTGQTGYIPS 137 G ++ YE++ + +L+ K+G+ + ++N + WW G+ G P Sbjct: 1 GSSGSSGDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGE--LNGRRGVFPD 58 Query: 138 NYVAPSDS 145 N+V Sbjct: 59 NFVKLLSG 66 >2HMH-A nrPDB Length = 152 Score = 55.8 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 25/95 (26%), Positives = 43/95 (45%), Gaps = 15/95 (15%) Query: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205 +Q +Y+ +T E+ LL P GTFL+R+S + + LSV K L + Sbjct: 31 LQESGFYWSAVTGGEANLLLSAE--PAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRI--- 85 Query: 206 KIRKLDSGGFYITSR-------TQFNSLQQLVAYY 233 + + G F + S +F+ + +LV +Y Sbjct: 86 ---QCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 117 >2YDL-A nrPDB Length = 69 Score = 55.8 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 13/64 (20%), Positives = 30/64 (46%), Gaps = 4/64 (6%) Query: 86 VTTFVALYDYESRTETDLSFKKGERLQIVNNT--EGDWWLAHSLSTGQTGYIPSNYVAPS 143 ++ YE++ + +L+ K+G+ + ++N + WW G+ G P N+V Sbjct: 2 SDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGE--LNGRRGVFPDNFVKLL 59 Query: 144 DSIQ 147 ++ Sbjct: 60 PPLE 63 >2BBU-A nrPDB Length = 164 Score = 55.4 bits (132), Expect = 6e-08, Method: Composition-based stats. Identities = 25/95 (26%), Positives = 43/95 (45%), Gaps = 15/95 (15%) Query: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205 +Q +Y+ +T E+ LL P GTFL+R+S + + LSV K L + Sbjct: 20 LQESGFYWSAVTGGEANLLLSAE--PAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRI--- 74 Query: 206 KIRKLDSGGFYITSR-------TQFNSLQQLVAYY 233 + + G F + S +F+ + +LV +Y Sbjct: 75 ---QCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHY 106 >1K4U-S nrPDB Length = 62 Score = 55.4 bits (132), Expect = 6e-08, Method: Composition-based stats. Identities = 15/59 (25%), Positives = 29/59 (49%), Gaps = 2/59 (3%) Query: 87 TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDS 145 + AL+ YE+ DL F++G+ + +++ +W S G+ G P +V S + Sbjct: 6 SQVEALFSYEATQPEDLEFQEGDIILVLSKVNEEWLEGES--KGKVGIFPKVFVEDSAT 62 >4AZW-A nrPDB Length = 471 Score = 55.0 bits (131), Expect = 9e-08, Method: Composition-based stats. Identities = 15/72 (20%), Positives = 29/72 (40%), Gaps = 5/72 (6%) Query: 338 YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILV 397 ++V E + L D L + + +A +E+ + H D+R N++V Sbjct: 318 WLVMEKLPGRLLSDMLAAG-----EEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMV 372 Query: 398 GENLVCKVADFG 409 ++ DFG Sbjct: 373 DARQHARLIDFG 384 >2K6D-A nrPDB Length = 62 Score = 54.6 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 13/56 (23%), Positives = 28/56 (50%), Gaps = 4/56 (7%) Query: 88 TFVALYDYESRTETDLSFKKGERLQIVNNT--EGDWWLAHSLSTGQTGYIPSNYVA 141 ++ YE++ + +L+ K+G+ + ++N + WW G+ G P N+V Sbjct: 5 YCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGE--LNGRRGVFPDNFVK 58 >4AZV-A nrPDB Length = 569 Score = 54.6 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 15/72 (20%), Positives = 29/72 (40%), Gaps = 5/72 (6%) Query: 338 YIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILV 397 ++V E + L D L + + +A +E+ + H D+R N++V Sbjct: 318 WLVMEKLPGRLLSDMLAAG-----EEIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMV 372 Query: 398 GENLVCKVADFG 409 ++ DFG Sbjct: 373 DARQHARLIDFG 384 >1YWO-A nrPDB Length = 64 Score = 54.2 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 19/53 (35%), Positives = 28/53 (52%), Gaps = 1/53 (1%) Query: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVA 141 AL+DY+++ E +L+F K +Q V +G WW Q + PSNYV Sbjct: 9 VKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYGGKKQL-WFPSNYVE 60 >2EQI-A nrPDB Length = 69 Score = 53.8 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 21/66 (31%), Positives = 29/66 (43%), Gaps = 1/66 (1%) Query: 80 GPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNY 139 G T ALYDY+++ +L+F +G + V+ G WW T Y PSNY Sbjct: 1 GSSGSSGRTVKALYDYKAKRSDELTFCRGALIHNVSKEPGGWWKG-DYGTRIQQYFPSNY 59 Query: 140 VAPSDS 145 V Sbjct: 60 VEDISG 65 >2V1R-A nrPDB Length = 80 Score = 53.8 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 20/74 (27%), Positives = 34/74 (45%), Gaps = 8/74 (10%) Query: 75 SPQRAGPL-AGGVTTFVALYDYESRTET-DLSFKKGERLQIVNNTEG-----DWWLAHSL 127 S + P+ + ALYD+ +++ KKG+ + I++ + DWW + Sbjct: 2 SEFGSEPIDPSKLEFARALYDFVPENPEMEVALKKGDLMAILSKKDPLGRDSDWWKVRT- 60 Query: 128 STGQTGYIPSNYVA 141 G GYIP NY+ Sbjct: 61 KNGNIGYIPYNYIE 74 >2K9G-A nrPDB Length = 73 Score = 53.8 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 13/56 (23%), Positives = 28/56 (50%), Gaps = 4/56 (7%) Query: 88 TFVALYDYESRTETDLSFKKGERLQIVNNT--EGDWWLAHSLSTGQTGYIPSNYVA 141 ++ YE++ + +L+ K+G+ + ++N + WW G+ G P N+V Sbjct: 11 YCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGE--LNGRRGVFPDNFVK 64 >6G38-A nrPDB Length = 357 Score = 53.8 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 38/181 (20%), Positives = 63/181 (34%), Gaps = 54/181 (29%) Query: 265 IPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPG---------TMSPEAFLQEAQ 315 +P E L+ K+G+G FGEV+ + T VAIK + + E L E Sbjct: 38 LPTEKLQRCEKIGEGVFGEVFQTIADHTP-VAIKIIAIEGPDLVNGSHQKTFEEILPEII 96 Query: 316 VMKK-----------------LRHEKLVQ-----LY------------------AVVSEE 335 + K+ L VQ L ++ Sbjct: 97 ISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDD 156 Query: 336 PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE-RMNYVHRDLRAAN 394 ++IV E+ G L+ ++ K L + Q+ + +A E + + HRDL N Sbjct: 157 QLFIVLEFEFGGIDLEQMRT---KLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGN 213 Query: 395 I 395 + Sbjct: 214 V 214 >3ENH-A nrPDB Length = 540 Score = 53.5 bits (127), Expect = 2e-07, Method: Composition-based stats. Identities = 27/163 (16%), Positives = 63/163 (38%), Gaps = 31/163 (19%) Query: 273 EVKLGQGCFGEVWMGTWNGTTRVAIK-TLKPGTMSPE--------AFLQEAQVMKKLRH- 322 E +G+G ++ ++ V IK +K G +EA+ + ++ Sbjct: 341 EHLIGKGAEADIKRDSYLD-FDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDF 399 Query: 323 ----EKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 378 + + V + I+ Y++ D ++ +D+A +I + Sbjct: 400 GIPAPYI---FDVDLDNKR-IMMSYINGKLAKDVIEDN----------LDIAYKIGEIVG 445 Query: 379 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTA 421 + + + +H DL +N + ++ + DFGL ++ +E A Sbjct: 446 KLHKNDVIHNDLTTSNFIFDKD--LYIIDFGLGKISNLDEDKA 486 >2ED1-A nrPDB Length = 76 Score = 53.5 bits (127), Expect = 3e-07, Method: Composition-based stats. Identities = 14/65 (21%), Positives = 30/65 (46%), Gaps = 1/65 (1%) Query: 77 QRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLST-GQTGYI 135 +G V +YD ++ + +L+F +GE + + + +WW+ H + G Sbjct: 1 GSSGSSGNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVF 60 Query: 136 PSNYV 140 P ++V Sbjct: 61 PVSFV 65 >1N5Z-A nrPDB Length = 92 Score = 53.5 bits (127), Expect = 3e-07, Method: Composition-based stats. Identities = 20/74 (27%), Positives = 34/74 (45%), Gaps = 8/74 (10%) Query: 75 SPQRAGPL-AGGVTTFVALYDYESRTET-DLSFKKGERLQIVNNTEG-----DWWLAHSL 127 S + P+ + ALYD+ +++ KKG+ + I++ + DWW + Sbjct: 2 SEFGSEPIDPSKLEFARALYDFVPENPEMEVALKKGDLMAILSKKDPLGRDSDWWKVRT- 60 Query: 128 STGQTGYIPSNYVA 141 G GYIP NY+ Sbjct: 61 KNGNIGYIPYNYIE 74 >1NM7-A nrPDB Length = 69 Score = 52.7 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 19/68 (27%), Positives = 30/68 (44%), Gaps = 7/68 (10%) Query: 80 GPLAGGVTTFVALYDYESRTET-DLSFKKGERLQIVNNTEG-----DWWLAHSLSTGQTG 133 G ALYD+ +++ KKG+ + I++ + DWW + G G Sbjct: 1 GSHHHHHHFARALYDFVPENPEMEVALKKGDLMAILSKKDPLGRDSDWWKVRT-KNGNIG 59 Query: 134 YIPSNYVA 141 YIP NY+ Sbjct: 60 YIPYNYIE 67 >1MV3-A nrPDB Length = 213 Score = 52.7 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 27/152 (17%), Positives = 47/152 (30%), Gaps = 27/152 (17%) Query: 3 SNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPK 62 + S+P +AS+ +PA G A + + S PA P Sbjct: 73 TTPSQPAEASEVAGGTQPAAGAQEPGETAASEAASSSLPAVVVETF------------PA 120 Query: 63 LFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIV-----NNT 117 G + + + R G + A +DY + +L K G+ + ++ Sbjct: 121 TVNG--TVEGGSGAGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQ 178 Query: 118 EGDW--------WLAHSLSTGQTGYIPSNYVA 141 + W W H G P N+ Sbjct: 179 DEGWLMGVKESDWNQHKKLEKCRGVFPENFTE 210 >5VE6-A nrPDB Length = 492 Score = 52.3 bits (124), Expect = 6e-07, Method: Composition-based stats. Identities = 12/70 (17%), Positives = 33/70 (47%), Gaps = 5/70 (7%) Query: 333 SEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQL-----VDMAAQIASGMAYVERMNYVH 387 ++ + ++T + + DF++ + P+ + Q+ +G+ +++ +H Sbjct: 172 EQDCVVVITREVPHQTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGIIH 231 Query: 388 RDLRAANILV 397 RDL N+L+ Sbjct: 232 RDLCLENLLL 241 Score = 44.6 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 28/134 (20%), Positives = 47/134 (35%), Gaps = 11/134 (8%) Query: 405 VADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRV 464 +++F A+ +Q K APE ++ K D + GIL+ EL Sbjct: 300 ISNFLKAKQKPGGTPNLQQ--KKSQARLAPEIVSASQY-RKFDEFQTGILIYELL---HQ 353 Query: 465 PYPGMVNREVLDQVERGYRMPCPPECP---ESLHDLMCQCWRKEPEERPTFEYLQAFLED 521 P P V ++ ++ R +P P L L +P +R + L+ Sbjct: 354 PNPFEVRAQLRERDYRQEDLPPLPALSLYSPGLQQLAHLLLEADPIKRIRIGEAKRVLQC 413 Query: 522 YFTSTEPQ--YQPG 533 + QPG Sbjct: 414 LLWGPRRELVQQPG 427 >2HSP-A nrPDB Length = 71 Score = 51.9 bits (123), Expect = 6e-07, Method: Composition-based stats. Identities = 20/60 (33%), Positives = 28/60 (46%), Gaps = 1/60 (1%) Query: 82 LAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVA 141 AL+DY+++ E +L+F K +Q V EG WW Q + PSNYV Sbjct: 2 SPTFKCAVKALFDYKAQREDELTFIKSAIIQNVEKQEGGWWRGDYGGKKQL-WFPSNYVE 60 >2CT4-A nrPDB Length = 70 Score = 51.9 bits (123), Expect = 7e-07, Method: Composition-based stats. Identities = 17/57 (29%), Positives = 30/57 (52%) Query: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDS 145 VA+Y +E +E +S +GE L ++ +GD W G GY+P++Y+ + Sbjct: 10 CVAIYHFEGSSEGTISMAEGEDLSLMEEDKGDGWTRVRRKEGGEGYVPTSYLRVTSG 66 >2DLM-A nrPDB Length = 68 Score = 51.5 bits (122), Expect = 9e-07, Method: Composition-based stats. Identities = 13/66 (19%), Positives = 28/66 (42%), Gaps = 2/66 (3%) Query: 80 GPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNY 139 G +D+++++ +L+ +KG+ + I + +W G+ G P+NY Sbjct: 1 GSSGSSGKAARLKFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEH--HGRLGIFPANY 58 Query: 140 VAPSDS 145 V Sbjct: 59 VEVLSG 64 >4MT6-A nrPDB Length = 456 Score = 51.1 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 16/80 (20%), Positives = 37/80 (46%), Gaps = 8/80 (10%) Query: 77 QRAGPLAGGVTTFVA--LYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGY 134 +G L G + A ++D+ + +L+FK G+ +++++ + DWW G+ Sbjct: 6 GGSGMLITGDSIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDE--EGW 63 Query: 135 IPSN----YVAPSDSIQAEE 150 P++ +V D ++ Sbjct: 64 FPASFVRLWVNQEDGVEEGP 83 >2ENM-A nrPDB Length = 77 Score = 50.8 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 19/74 (25%), Positives = 35/74 (47%), Gaps = 4/74 (5%) Query: 77 QRAGPLAGGVTTFVALYDYESR-TETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYI 135 +G +G T +YD+ + +L+ +GE + + N G WL + G+ G + Sbjct: 1 GSSG-SSGMATKARVMYDFAAEPGNNELTVTEGEIITVTNPNVGGGWLEGKNNKGEQGLV 59 Query: 136 PSNYVA--PSDSIQ 147 P++YV P+D Sbjct: 60 PTDYVEILPNDGKD 73 >2M0Y-A nrPDB Length = 74 Score = 50.8 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 18/67 (26%), Positives = 35/67 (52%), Gaps = 2/67 (2%) Query: 81 PLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSL-STGQTGYIPSNY 139 P VA Y+Y++R +LS + G+ + I+ EG W+ ++L + G P++Y Sbjct: 6 PTKREEKYGVAFYNYDARGADELSLQIGDTVHILETYEG-WYRGYTLRKKSKKGIFPASY 64 Query: 140 VAPSDSI 146 + ++I Sbjct: 65 IHLKEAI 71 >2NWM-A nrPDB Length = 65 Score = 50.4 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 27/50 (54%), Gaps = 2/50 (4%) Query: 92 LYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVA 141 +D+++++ +L+ +KG+ + I + +W G+ G P+NYV Sbjct: 7 KFDFQAQSPKELTLQKGDIVYIHKEVDKNWLEGEH--HGRLGIFPANYVE 54 >1BB9-A nrPDB Length = 115 Score = 50.4 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 15/89 (16%), Positives = 28/89 (31%), Gaps = 13/89 (14%) Query: 69 SSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIV-----NNTEGDW-- 121 + + T+ R G + A +DY + +L K G+ + ++ + W Sbjct: 27 AVEGSTTTGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLM 86 Query: 122 ------WLAHSLSTGQTGYIPSNYVAPSD 144 W H G P N+ Sbjct: 87 GVKESDWNQHKELEKCRGVFPENFTERVQ 115 >2DJQ-A nrPDB Length = 68 Score = 49.6 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 16/71 (22%), Positives = 28/71 (39%), Gaps = 8/71 (11%) Query: 75 SPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGY 134 S +GP AL +Y + DL F KG+ + + + +W+ G +G Sbjct: 2 SSGSSGP------RAKALCNYRGKNPGDLKFNKGDVILLRRQLDENWYQGE--INGVSGI 53 Query: 135 IPSNYVAPSDS 145 P++ V Sbjct: 54 FPASSVEVISG 64 >2XKX-A nrPDB Length = 721 Score = 49.2 bits (116), Expect = 5e-06, Method: Composition-based stats. Identities = 22/106 (20%), Positives = 43/106 (40%), Gaps = 12/106 (11%) Query: 68 NSSDTVTSPQRAGPLAGGVTTFVALYDYESRTE-----TDLSFKKGERLQIVNNTEGDWW 122 +S + T+ R+ P G AL+DY+ + LSF+ G+ L +++ + +WW Sbjct: 411 SSLGSGTASLRSNPKRGF--YIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDAGDEEWW 468 Query: 123 LAHSLSTGQT----GYIPSNYVAPSDSIQA-EEWYFGKITRRESER 163 A + + G+IPS + +G + + Sbjct: 469 QARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGRE 514 >1WXU-A nrPDB Length = 93 Score = 48.8 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 22/80 (27%), Positives = 35/80 (43%), Gaps = 8/80 (10%) Query: 65 GGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD---W 121 G SS T + + A YD+ + ++ ++SF+ G+ L + + Sbjct: 1 GSSGSSGTNWASGEDDHV-----VARAEYDFVAVSDEEISFRAGDMLNLALKEQQPKVRG 55 Query: 122 WLAHSLSTGQTGYIPSNYVA 141 WL SL TG IP+NYV Sbjct: 56 WLLASLDGQTTGLIPANYVK 75 >2DYB-A nrPDB Length = 341 Score = 48.8 bits (115), Expect = 7e-06, Method: Composition-based stats. Identities = 15/60 (25%), Positives = 29/60 (48%), Gaps = 2/60 (3%) Query: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEE 150 AL+D+ ++ +L+FK G+ + +++ DW G TG P ++V E+ Sbjct: 179 ALFDFTGNSKLELNFKAGDVIFLLSRINKDWLEG--TVRGATGIFPLSFVKILKDFPEED 236 >1Z9Q-A nrPDB Length = 79 Score = 48.4 bits (114), Expect = 8e-06, Method: Composition-based stats. Identities = 15/59 (25%), Positives = 28/59 (47%), Gaps = 2/59 (3%) Query: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149 AL+D+ ++ +L+FK G+ + +++ DW G TG P ++V E Sbjct: 23 ALFDFTGNSKLELNFKAGDVIFLLSRINKDWLEG--TVRGATGIFPLSFVKILKDFPEE 79 >4CYJ-A nrPDB Length = 438 Score = 48.1 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 21/146 (14%), Positives = 51/146 (34%), Gaps = 20/146 (13%) Query: 280 CFGE---VWMGTW-NGTTRVAIKTLK-PGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE 334 CFG V+ A++ L+ + +A L + KK+++ +V ++ V + Sbjct: 64 CFGYPSWVYKAQNSRNGRHYALRRLEGYRLTNEKAILNVMKDWKKIKNASIVTIHEVFTT 123 Query: 335 EPI---YIVTEYMSKGSLLDFLKGETGKYL-----------RLPQLVDMAAQIASGMAYV 380 ++ Y L L+ + + + QIA+ + + Sbjct: 124 REFGDSSLIFAY-DFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIANALKTI 182 Query: 381 ERMNYVHRDLRAANILVGENLVCKVA 406 R L + I++ + +++ Sbjct: 183 HSNRLAARCLEPSKIILTDINRIRLS 208 >2RQT-A nrPDB Length = 61 Score = 48.1 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 13/56 (23%), Positives = 28/56 (50%), Gaps = 1/56 (1%) Query: 86 VTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLST-GQTGYIPSNYV 140 V +YD ++ + +L+F +GE + + + +WW+ H + G P ++V Sbjct: 1 VRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFV 56 >1W6X-A nrPDB Length = 60 Score = 47.7 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 14/51 (27%), Positives = 27/51 (52%), Gaps = 2/51 (3%) Query: 91 ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVA 141 AL+D+ ++ +L+FK G+ + +++ DW G TG P ++V Sbjct: 9 ALFDFTGNSKLELNFKAGDVIFLLSRINKDWLEG--TVRGATGIFPLSFVK 57 >1J3T-A nrPDB Length = 74 Score = 47.3 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 13/74 (17%), Positives = 29/74 (39%), Gaps = 3/74 (4%) Query: 77 QRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIP 136 +G AL + ++ + L+F K + + ++ + +WW G G+ P Sbjct: 1 GSSGSSGVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGE--VHGGRGWFP 57 Query: 137 SNYVAPSDSIQAEE 150 +YV ++ Sbjct: 58 KSYVKIIPGSESGP 71 >1UE9-A nrPDB Length = 80 Score = 46.9 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 16/70 (22%), Positives = 28/70 (40%), Gaps = 9/70 (12%) Query: 75 SPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTG---Q 131 S +G +A + +VA LS G+ + I+ WW + G Q Sbjct: 2 SSGSSGEIAQVTSAYVA------SGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQ 55 Query: 132 TGYIPSNYVA 141 G+ P+++V Sbjct: 56 KGWFPASHVK 65 >1TQM-A nrPDB Length = 282 Score = 46.9 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 26/134 (19%), Positives = 49/134 (36%), Gaps = 20/134 (14%) Query: 275 KLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE 334 K+G F +V G L ++ + E + ++KL+ + ++YA Sbjct: 123 KVGHTSFKKVKEKRDYGD-------LHFSVLAIRSARNEFRALQKLQGLAVPKVYAW--- 172 Query: 335 EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAAN 394 E ++ E + L + L + + ++A + VH DL N Sbjct: 173 EGNAVLMELIDAKELYRVRVENPDEVLDM-----ILEEVAK---FYH-RGIVHGDLSQYN 223 Query: 395 ILVGENLVCKVADF 408 +LV E + DF Sbjct: 224 VLVSEEG-IWIIDF 236 >4BWP-A nrPDB Length = 448 Score = 46.9 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 24/162 (14%), Positives = 52/162 (32%), Gaps = 39/162 (24%) Query: 285 WMGTWNGTT-RVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVS-----EEPIY 338 + T N T + ++ + + + ++ KKL+H +VQL V + + + Sbjct: 67 YRATHNTTGYKYCLRRIHGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTTKAFGDNSLV 126 Query: 339 IVTEYMSK--GSLLDFL---------------------------KGETGKYLRLPQLVDM 369 +V +Y L + + G L + + Sbjct: 127 LVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPLLPEATIWSI 186 Query: 370 AAQIASGMAYVERMNYVHRDLRAANILVGENLV----CKVAD 407 Q+ +G+ + + L I+V V C ++D Sbjct: 187 IMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >4WSI-A nrPDB Length = 394 Score = 46.5 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 19/90 (21%), Positives = 33/90 (36%), Gaps = 13/90 (14%) Query: 81 PLAGGVTTFVALYDYESRTET-------DLSFKKGERLQIVNNTEGDWWLA--HSLSTGQ 131 P V A +DY+ + LSF+KG+ L +++ + +WW A Q Sbjct: 111 PAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQ 170 Query: 132 --TGYIPSNYVAPSDSIQAEEWYFGKITRR 159 G +P + + Y R+ Sbjct: 171 PLAGLVP--GKEEILTYEEMSLYHQPANRK 198 >4IIO-A nrPDB Length = 66 Score = 46.5 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 14/62 (22%), Positives = 28/62 (45%), Gaps = 3/62 (4%) Query: 80 GPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNY 139 G G + AL + ++ + L+F K + + ++ + +WW G G+ P +Y Sbjct: 2 GMAQGALLKAQALCSWTAKKDNHLNFSKHDIITVLEQ-QENWWFGE--VHGGRGWFPKSY 58 Query: 140 VA 141 V Sbjct: 59 VK 60 >1UUS-A nrPDB Length = 473 Score = 46.1 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 26/115 (22%), Positives = 49/115 (42%), Gaps = 18/115 (15%) Query: 121 W-WLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRE 179 W W S+ T + Y ++ E +G + R+E L N + GTF++R Sbjct: 329 WVWFGKSMQTLR-------YQRHISTLWQEGIIYGYMGRQEVNDALQNQD--PGTFIIRF 379 Query: 180 SETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGF------YITSRTQFNSLQQ 228 SE G + ++ + +KHY ++ D+ +++ +QF +L Q Sbjct: 380 SERNPGQFGIAYIGVEMPA--RIKHYLVQPNDTAAAKKTFPDFLSEHSQFVNLLQ 432 >1MV0-B nrPDB Length = 81 Score = 46.1 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 14/78 (17%), Positives = 24/78 (30%), Gaps = 13/78 (16%) Query: 77 QRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIV-----NNTEGDW--------WL 123 R G + A +DY + +L K G+ + ++ + W W Sbjct: 1 GRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDWN 60 Query: 124 AHSLSTGQTGYIPSNYVA 141 H G P N+ Sbjct: 61 QHKKLEKCRGVFPENFTE 78 >1UGV-A nrPDB Length = 72 Score = 45.7 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 19/65 (29%), Positives = 29/65 (44%), Gaps = 1/65 (1%) Query: 77 QRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIP 136 +G ALY ++ +++LSF G V+ ++ WL G+TG IP Sbjct: 1 GSSGSSGTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEPGWL-EGTLNGKTGLIP 59 Query: 137 SNYVA 141 NYV Sbjct: 60 ENYVE 64 >2IZV-A nrPDB Length = 187 Score = 45.4 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 22/127 (17%), Positives = 43/127 (33%), Gaps = 12/127 (9%) Query: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205 I Y+G + + +E LL P GTFL+R+S + +S + + ++ Sbjct: 31 INNNPCYWGVMDKYAAEALL--EGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIE-- 86 Query: 206 KIRKLDSGGFYITSRTQF--NSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAW 263 + + F F + L+ +Y + + S P + Sbjct: 87 --QWNHNFSFDAHDPCVFHSPDITGLLEHYKDPSA----CMFFEPLLSTPLIRTFPFSLQ 140 Query: 264 EIPRESL 270 I R + Sbjct: 141 HICRTVI 147 >1I07-A nrPDB Length = 60 Score = 45.4 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 14/55 (25%), Positives = 32/55 (58%), Gaps = 2/55 (3%) Query: 87 TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVA 141 + YD+ +R ++LS K + L+I+++ WW + ++G +G++P+N + Sbjct: 2 KYAKSKYDFVARNSSELSVMKDDVLEILDDRR-QWWKVRN-ASGDSGFVPNNILD 54 >3RNJ-A nrPDB Length = 67 Score = 45.0 bits (105), Expect = 9e-05, Method: Composition-based stats. Identities = 17/67 (25%), Positives = 29/67 (43%), Gaps = 2/67 (2%) Query: 80 GPLAGGVTTFVALYDYESRTETDL-SFKKGERLQIV-NNTEGDWWLAHSLSTGQTGYIPS 137 GPL G A++ + + + L SFK+G+ + ++ W S T G+ P Sbjct: 1 GPLGSGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPF 60 Query: 138 NYVAPSD 144 +Y D Sbjct: 61 SYTRVLD 67 >2DMO-A nrPDB Length = 68 Score = 44.6 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 14/66 (21%), Positives = 25/66 (37%), Gaps = 2/66 (3%) Query: 80 GPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNY 139 G L+ + T+ +L G + ++ +W A + GQ G +P NY Sbjct: 1 GSSGSSGEAHRVLFGFVPETKEELQVMPGNIVFVLKKGNDNW--ATVMFNGQKGLVPCNY 58 Query: 140 VAPSDS 145 + P Sbjct: 59 LEPVSG 64 >4WWA-A nrPDB Length = 261 Score = 43.8 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 26/128 (20%), Positives = 48/128 (37%), Gaps = 26/128 (20%) Query: 302 PGTMSPEAFLQEAQVMKKLRHEKLVQLYAV-----VSEEPIYIVTEYM----SKG----S 348 ++ L E++++ KL L+ V +I E++ G + Sbjct: 65 DQALTKHRTLNESRLLAKL---YLIPGLCVPQLIACDPYNGFIWLEFLGEDLPGGHGFSN 121 Query: 349 LLDFLKGETGKYLR---LPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENL---V 402 L +FL L + QI G+ + +Y H DL ++NI++ + Sbjct: 122 LKNFLWMHDQDPYSDLVATTLRKVGRQI--GL--LHWNDYCHGDLTSSNIVLVRDGARWT 177 Query: 403 CKVADFGL 410 + DFGL Sbjct: 178 PHLIDFGL 185 >3BYV-A nrPDB Length = 377 Score = 43.8 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 34/187 (18%), Positives = 60/187 (32%), Gaps = 31/187 (16%) Query: 354 KGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARL 413 T K L + + Q+ +A + VH LR +I++ + + F Sbjct: 196 HSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGFE---- 251 Query: 414 IEDNEYTARQGAKFPIKWTAPEA------ALYGR-----FTIKSDVWSFGILLTELTTKG 462 AR + + PE Y R T D W+ G+++ + Sbjct: 252 -HLVRDGARVVSSVSRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCA- 309 Query: 463 RVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEER---------PTFE 513 +P + L E +R P+ + L+ R E+R P +E Sbjct: 310 DLP---ITKDAALGGSEWIFR--SCKNIPQPVRALLEGFLRYPKEDRLLPLQAMETPEYE 364 Query: 514 YLQAFLE 520 L+ L Sbjct: 365 QLRTELS 371 >3DZO-A nrPDB Length = 413 Score = 43.8 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 32/197 (16%), Positives = 61/197 (30%), Gaps = 34/197 (17%) Query: 354 KGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARL 413 T K L + + Q+ +A + VH LR +I++ + + F Sbjct: 201 HSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGFE---- 256 Query: 414 IEDNEYTARQGAKFPIKWTAPE-----AALYGRF-----TIKSDVWSFGILLTELTTKGR 463 A + + PE +G+ T D W+ G+ + + Sbjct: 257 -HLVRDGASAVSPIGRGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCA-- 313 Query: 464 VPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEER---------PTFEY 514 + N + + P+ + L+ R E+R P +E Sbjct: 314 ----DLPNTDDAALGGSEWIFRSCKNIPQPVRALLEGFLRYPKEDRLLPLQAMETPEYEQ 369 Query: 515 LQAFLEDYFTSTEPQYQ 531 L+ L ++ P YQ Sbjct: 370 LRTEL----SAALPLYQ 382 >2CR4-A nrPDB Length = 126 Score = 43.1 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 24/100 (24%), Positives = 41/100 (41%), Gaps = 14/100 (14%) Query: 137 SNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDN 196 S +V ++S + E + R E + G + +R S T G V + Sbjct: 18 SVFVNTTESCEVERLFKATSPRGEPQ---------DGLYCIRNSSTKSGK----VLVVWD 64 Query: 197 AKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKH 236 V++Y+I + DS FY+ F S+ +V +Y H Sbjct: 65 ETSNKVRNYRIFEKDS-KFYLEGEVLFVSVGSMVEHYHTH 103 >2W1Z-A nrPDB Length = 368 Score = 43.1 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 35/197 (17%), Positives = 61/197 (30%), Gaps = 34/197 (17%) Query: 354 KGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARL 413 T K L + + Q+ A ++ VH D + NIL+ + + F Sbjct: 181 HSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGGVFLTGFE---- 236 Query: 414 IEDNEYTARQGAKFPIKWTAPEAALYG--RF--------TIKSDVWSFGILLTELTTKGR 463 A + + PE + T D W+ G+ + + Sbjct: 237 -HLVRDGASAVSPIGRGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWCA-D 294 Query: 464 VPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERP---------TFEY 514 +P L +E YR P+ + L+ R E+R +E Sbjct: 295 LP---NTEDAELGGIEWIYR--RCKNIPQPVRALLEGFLRYSKEDRLLPLQAMETSEYEQ 349 Query: 515 LQAFLEDYFTSTEPQYQ 531 L+ L ++ P YQ Sbjct: 350 LRTEL----SAVLPLYQ 362 >4DEX-A nrPDB Length = 339 Score = 42.7 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 25/139 (17%), Positives = 51/139 (36%), Gaps = 18/139 (12%) Query: 94 DYESRTETD-------LSFKKGERLQIVNNTEGDWWLAHSLSTGQT-GYIPSNYVAPSDS 145 Y + E D +SF+ + L + DWW+ + G G+IPS + Sbjct: 48 SYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMR 107 Query: 146 IQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHY 205 +Q E+ ++ L+++ R F + T S+ G ++K Y Sbjct: 108 LQHEQ---------RAKEFKLHSKEKRMPFFKKTEHTPPYDVVPSMRPVV-LVGPSLKGY 157 Query: 206 KIRKLDSGGFYITSRTQFN 224 ++ + + + +F Sbjct: 158 EVTDMMQKALFDFLKHRFE 176 >2KYM-A nrPDB Length = 120 Score = 42.7 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 16/64 (25%), Positives = 34/64 (53%), Gaps = 1/64 (1%) Query: 89 FVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLST-GQTGYIPSNYVAPSDSIQ 147 V LY++++ + +L GE L I + + +W++A ++ G G +P +YV D + Sbjct: 6 AVTLYEFKAERDDELDVSPGENLSICAHYDYEWFIAKPINRLGGPGLVPVSYVRIIDLMD 65 Query: 148 AEEW 151 ++ Sbjct: 66 PAKY 69 >2MIO-A nrPDB Length = 70 Score = 42.3 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 17/56 (30%), Positives = 25/56 (44%), Gaps = 1/56 (1%) Query: 86 VTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVA 141 A+Y E+ ++LSF+ G + V + WL G+ G IP NYV Sbjct: 14 SRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWL-EGTLNGKRGLIPQNYVK 68 >2VKN-A nrPDB Length = 70 Score = 41.9 bits (97), Expect = 6e-04, Method: Composition-based stats. Identities = 20/47 (42%), Positives = 30/47 (63%), Gaps = 2/47 (4%) Query: 102 DLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQA 148 ++SF++ E LQ+ ++ EG WW A + G+TG IPSNYV D + Sbjct: 23 EISFEQNEILQV-SDIEGRWWKARR-ANGETGIIPSNYVQLIDGPEE 67 >2RQW-A nrPDB Length = 105 Score = 41.9 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 16/61 (26%), Positives = 30/61 (49%), Gaps = 1/61 (1%) Query: 85 GVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSL-STGQTGYIPSNYVAPS 143 G + LYD+++ +L+ GE L I + +W++A + G G +P +V+ Sbjct: 1 GSLYAIVLYDFKAEKADELTTYVGENLFICAHHNCEWFIAKPIGRLGGPGLVPVGFVSII 60 Query: 144 D 144 D Sbjct: 61 D 61 >5YK0-A nrPDB Length = 452 Score = 41.5 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 26/171 (15%), Positives = 55/171 (32%), Gaps = 48/171 (28%) Query: 282 GEVWMGTWNGTTRVAIKTLKPGTMSP-----EAFLQEAQVMKKL---------------- 320 G+V W+ VA+K PG + + V+K+L Sbjct: 146 GQVHKAIWSDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVER 205 Query: 321 ----------------------RHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETG 358 H + Q+ VV+ P ++ E++ + + ++ G Sbjct: 206 TEMELDYRLEAANQRAFAKAYHDHPRF-QVPHVVASAPKVVIQEWIEGVPMAEIIRH--G 262 Query: 359 KYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFG 409 + + + A++ R+ +H D N ++ + + DFG Sbjct: 263 TTEQRDLIGTLLAELT--FDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFG 311 >3A98-A nrPDB Length = 184 Score = 41.1 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 15/71 (21%), Positives = 30/71 (42%), Gaps = 6/71 (8%) Query: 75 SPQRAGPLA----GGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTG 130 S +G VA+Y+++ LS + G+ ++I T GDW+ + + Sbjct: 2 SSGSSGMAPWRKADKERHGVAIYNFQGSGAPQLSLQIGDVVRI-QETCGDWYRGYLIKHK 60 Query: 131 Q-TGYIPSNYV 140 G P +++ Sbjct: 61 MLQGIFPKSFI 71 >2RQR-A nrPDB Length = 119 Score = 40.7 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 13/52 (25%), Positives = 27/52 (51%), Gaps = 2/52 (3%) Query: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQ-TGYIPSNYV 140 VA+Y+++ LS + G+ ++I T GDW+ + + G P +++ Sbjct: 63 VAIYNFQGSGAPQLSLQIGDVVRI-QETCGDWYRGYLIKHKMLQGIFPKSFI 113 >1U3O-A nrPDB Length = 82 Score = 40.7 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 18/69 (26%), Positives = 32/69 (46%), Gaps = 5/69 (7%) Query: 75 SPQRAGP-LAGGVTTFVALYDYESRTETDLSFKKGERLQIVNN--TEGDWWLAHSLSTG- 130 SP G L+GG V L D+ + ++LS + G+ ++++ W L + Sbjct: 5 SPGIPGSTLSGGCELTVVLQDFSAAHSSELSIQVGQTVELLERPSERPGWCLVRTTERSP 64 Query: 131 -QTGYIPSN 138 Q G +PS+ Sbjct: 65 PQEGLVPSS 73 >5F3Y-A nrPDB Length = 621 Score = 40.7 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 23/104 (22%), Positives = 38/104 (36%), Gaps = 5/104 (4%) Query: 42 ASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTET 101 A+ D G A E + + + G L +AL D + + Sbjct: 499 ANRDAPGGKKLLLATLQEEYEFVSPSSVAIAEMVALFLGGLKERSVFAMALQDRRATDDI 558 Query: 102 DL-SFKKGERLQIVNNT----EGDWWLAHSLSTGQTGYIPSNYV 140 L FKKG+ L + +W L + TG+TG +P+ + Sbjct: 559 TLLPFKKGDLLILTKKQGLLASENWALGQNDRTGKTGLVPTACL 602 >5GJW-B nrPDB Length = 106 Score = 40.4 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 24/104 (23%), Positives = 35/104 (33%), Gaps = 17/104 (16%) Query: 36 QTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDY 95 Q P + R A A +P F + SP P+ G VA+ Sbjct: 7 QGPHMALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVEG-----VAI--- 58 Query: 96 ESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQT-GYIPSN 138 +F+ + L I DWW+ + G G+IPS Sbjct: 59 --------TFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSP 94 >3Q60-A nrPDB Length = 371 Score = 39.2 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 25/176 (14%), Positives = 55/176 (31%), Gaps = 24/176 (13%) Query: 369 MAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFP 428 + AQ+ A ++ VH N+ + + + D ++ L + T + P Sbjct: 199 LTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGD--VSALWKVG--TRGPASSVP 254 Query: 429 IKWTAPEAAL--YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPC 486 + + E FT + W G+ + + +P+ + R+P Sbjct: 255 VTYAPREFLNASTATFTHALNAWQLGLSIYRVWCL-FLPFGLVTPGIKGSWKRPSLRVPG 313 Query: 487 PPE--------CPESLHDLMCQCWRKEPEER---------PTFEYLQAFLEDYFTS 525 P+ + L+ + + R P F LQ + ++ Sbjct: 314 TDSLAFGSCTPLPDFVKTLIGRFLNFDRRRRLLPLEAMETPEFLQLQNEISSSLST 369 >6G18-v nrPDB Length = 552 Score = 39.2 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 20/162 (12%), Positives = 50/162 (30%), Gaps = 36/162 (22%) Query: 272 LEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQ---- 327 + ++G G ++++ + A+K + G S + K H V Sbjct: 97 VGNQMGVGKESDIYIVANEEGQQFALKLHRLGRTSFRNLKNKRDYHK---HRHNVSWLYL 153 Query: 328 -----LYAVVSEEPIY----------------IVTEYMSKGSLLDFLKGETGKYLRLPQL 366 + + +Y +V E ++ L + + Sbjct: 154 SRLSAMKEFAYMKALYERKFPVPKPIDYNRHAVVMELINGYPLCQ-IHHVEDPASVYDEA 212 Query: 367 VDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADF 408 +++ ++A +H D N+++ E+ + DF Sbjct: 213 MELIVKLA-------NHGLIHGDFNEFNLILDESDHITMIDF 247 >1SPK-A nrPDB Length = 72 Score = 39.2 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 21/50 (42%), Gaps = 1/50 (2%) Query: 97 SRTETDLSFKKGERLQIV-NNTEGDWWLAHSLSTGQTGYIPSNYVAPSDS 145 +T LSF +G+ L ++ + W +T G+ PS+Y Sbjct: 19 GNNKTLLSFAQGDVLTLLIPEEKDGWLYGEHDTTKARGWFPSSYTKLLSG 68 >6FDN-A nrPDB Length = 320 Score = 39.2 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 20/162 (12%), Positives = 50/162 (30%), Gaps = 36/162 (22%) Query: 272 LEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQ---- 327 + ++G G ++++ + A+K + G S + K H V Sbjct: 97 VGNQMGVGKESDIYIVANEEGQQFALKLHRLGRTSFRNLKNKRDYHK---HRHNVSWLYL 153 Query: 328 -----LYAVVSEEPIY----------------IVTEYMSKGSLLDFLKGETGKYLRLPQL 366 + + +Y +V E ++ L + + Sbjct: 154 SRLSAMKEFAYMKALYERKFPVPKPIDYNRHAVVMELINGYPLCQ-IHHVEDPASVYDEA 212 Query: 367 VDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADF 408 +++ ++A +H D N+++ E+ + DF Sbjct: 213 MELIVKLA-------NHGLIHGDFNEFNLILDESDHITMIDF 247 >2DE0-X nrPDB Length = 526 Score = 38.8 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 13/63 (20%), Positives = 26/63 (41%) Query: 90 VALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 149 +A+Y ++ RT ++ + G+ + + N + + G+TG PS V Sbjct: 446 IAIYAHQPRTADEIPMEPGDIIGVAGNHWDGYSKGVNRKLGRTGLYPSYKVREKIETVKY 505 Query: 150 EWY 152 Y Sbjct: 506 PTY 508 >1T0J-A nrPDB Length = 132 Score = 38.8 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 16/64 (25%), Positives = 27/64 (42%), Gaps = 8/64 (12%) Query: 95 YESRTETD-------LSFKKGERLQIVNNTEGDWWLAHSLSTGQT-GYIPSNYVAPSDSI 146 Y + E D +SF+ + L + DWW+ + G G+IPS + + Sbjct: 57 YSAAQEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRL 116 Query: 147 QAEE 150 Q E+ Sbjct: 117 QHEQ 120 >5I35-A nrPDB Length = 393 Score = 38.8 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 28/174 (16%), Positives = 53/174 (30%), Gaps = 40/174 (22%) Query: 282 GEVWMGTWNGTTRVAIKT-------------------LKPGTMSPEAFLQE--AQVMKK- 319 G+V + G VA+K L M PE E V+++ Sbjct: 88 GQVHLARMKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRE 147 Query: 320 --LRHEK------LVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAA 371 L + + ++ P + V E + + L E L Q ++ Sbjct: 148 LALECDYQREAACARKFRDLLKGHPFFYVPEIVDELCSPHVLTTELVSGFPLDQAEGLSQ 207 Query: 372 QIASGMAY---------VERMNYVHRDLRAANILVGENLV-CKVADFGLARLIE 415 +I + + Y + +++ D +N + DFG R + Sbjct: 208 EIRNEICYNILVLCLRELFEFHFMQTDPNWSNFFYDPQQHKVALLDFGATREYD 261 >4ZW2-A nrPDB Length = 333 Score = 38.4 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 26/115 (22%), Positives = 38/115 (33%), Gaps = 18/115 (15%) Query: 26 GAGGGAFPASQTPSKPA-SADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAG 84 G G S + A + R A A +P F + SP P+ G Sbjct: 1 GPGSSDSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQG 60 Query: 85 GVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQT-GYIPSN 138 VA+ +F+ + L I DWW+ + G G+IPS Sbjct: 61 -----VAI-----------TFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSP 99 >5IXI-A nrPDB Length = 544 Score = 38.0 bits (87), Expect = 0.010, Method: Composition-based stats. Identities = 21/114 (18%), Positives = 40/114 (35%), Gaps = 8/114 (7%) Query: 153 FGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKG-----LNVKHYKI 207 G I + L + G +++R S T ++V+ F+ ++ K+++I Sbjct: 423 HGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQI 482 Query: 208 RKLDSGGFYITSRTQFNSLQQLVAYYSKH---ADGLCHRLTTVCPTSKPQTQGL 258 S F SL L+++ K D + L C + L Sbjct: 483 EVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNL 536 >6DFL-A nrPDB Length = 259 Score = 37.7 bits (86), Expect = 0.014, Method: Composition-based stats. Identities = 33/165 (20%), Positives = 65/165 (39%), Gaps = 15/165 (9%) Query: 277 GQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAV----- 331 G+G F ++ G G +A K L + QE Q +++L + + AV Sbjct: 45 GRGYFVKIHRGI--GWGEIA-KNLLTAKLPVLGARQEWQAIRRLHEAGVATMTAVAYGER 101 Query: 332 ---VSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQ-IASGMAYVERMNYVH 387 + + +IVTE ++ L+ + + P+L + +A + + R H Sbjct: 102 GSDPARQHSFIVTEELAPTVDLEVFSQDWRERPPPPRLKRALVEAVARMVGDMHRAGVNH 161 Query: 388 RDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT 432 RD + L+ + DF L+ + + + A+ P +W Sbjct: 162 RDCYICHFLLHTDKPVSADDFRLSVI---DLHRAQTRDATPKRWR 203 >2KXC-A nrPDB Length = 67 Score = 37.3 bits (85), Expect = 0.016, Method: Composition-based stats. Identities = 10/50 (20%), Positives = 21/50 (42%), Gaps = 1/50 (2%) Query: 97 SRTETDLSFKKGERLQIV-NNTEGDWWLAHSLSTGQTGYIPSNYVAPSDS 145 +T LSF +G+ + ++ + W + G+ PS+Y + Sbjct: 18 GSNKTLLSFAQGDVITLLIPEEKDGWLYGEHDVSKARGWFPSSYTKLLEE 67 >4CZY-B nrPDB Length = 429 Score = 36.9 bits (84), Expect = 0.022, Method: Composition-based stats. Identities = 21/138 (15%), Positives = 47/138 (34%), Gaps = 17/138 (12%) Query: 285 WMGTWNGTTR-VAIKTLK-PGTMSPEAFLQEAQVMKKLRHEKLVQLYA-----VVSEEPI 337 + N R A++ ++ + +A L + KK+ + +V ++ + + Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLTNEKAILNVTKEWKKIINANIVTVHEAFTTEFFGDSSL 120 Query: 338 YIVTEYMSKGS-LLDFL--------KGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHR 388 V ++ L D + + L QIA+ + + R Sbjct: 121 IFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAIHNAKLAAR 180 Query: 389 DLRAANILVGENLVCKVA 406 L + I + EN ++A Sbjct: 181 CLELSKI-IWENNRIRLA 197 >3PJP-A nrPDB Length = 199 Score = 36.5 bits (83), Expect = 0.030, Method: Composition-based stats. Identities = 20/104 (19%), Positives = 45/104 (43%), Gaps = 13/104 (12%) Query: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR 208 +YF +++E L + E RG F++R+S ++ + +H I+ Sbjct: 10 HPYYF-PFNGKQAEDYLRSKE--RGDFVIRQSSRGDDHLAITWKLDKDLF----QHVDIQ 62 Query: 209 KLDS------GGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTT 246 +L+ G + +++ L Q++ Y ++ L + LT+ Sbjct: 63 ELEKENPLALGKVLVVEGQRYHDLDQIIVEYLQNKIRLLNELTS 106 >1VYV-A nrPDB Length = 359 Score = 36.1 bits (82), Expect = 0.036, Method: Composition-based stats. Identities = 12/36 (33%), Positives = 16/36 (44%), Gaps = 1/36 (2%) Query: 104 SFKKGERLQIVNNTEGDWWLAHSLSTGQT-GYIPSN 138 SF + L I DWW+ + G G+IPS Sbjct: 70 SFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSP 105 >4Y5W-A nrPDB Length = 549 Score = 35.7 bits (81), Expect = 0.051, Method: Composition-based stats. Identities = 20/93 (21%), Positives = 34/93 (36%), Gaps = 3/93 (3%) Query: 154 GKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSG 213 G I+++ LLLN P GTFL+R S++ G ++ +++ + Sbjct: 431 GFISKQYVTSLLLNE--PDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDL 488 Query: 214 GFYITSRTQFNSLQQLVAYYSKHADGLCHRLTT 246 + + L QL Y K R Sbjct: 489 SI-RSLGDRIRDLAQLKNLYPKKPKDEAFRSHY 520 >4BVU-A nrPDB Length = 211 Score = 35.3 bits (80), Expect = 0.070, Method: Composition-based stats. Identities = 24/174 (13%), Positives = 50/174 (28%), Gaps = 28/174 (16%) Query: 237 ADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVA 296 + G+ T + + P L +GQG E++ + + Sbjct: 13 SSGMKITSTIIQTPFPFENNNSHAGIVTEPI----LGKLIGQGSTAEIFEDVNDSSALY- 67 Query: 297 IKTLKPGTMSPEAFLQ----EAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDF 352 K L+ E++ L+ + +V +Y G + Sbjct: 68 -KKYDLIGNQYNEILEMAWQESE------------LFNAFYGDEASVVIQY--GGDVYLR 112 Query: 353 LKGETGKYLRLPQLVDMAAQI----ASGMAYVERMNYVHRDLRAANILVGENLV 402 + G L D+ I + + ++ +H DL N+L + Sbjct: 113 MLRVPGTPLSDIDTADIPDNIESLYLQLICKLNELSIIHYDLNTGNMLYDKESE 166 >1K1Z-A nrPDB Length = 78 Score = 35.3 bits (80), Expect = 0.073, Method: Composition-based stats. Identities = 11/41 (26%), Positives = 20/41 (48%), Gaps = 1/41 (2%) Query: 103 LSFKKGERLQIVN-NTEGDWWLAHSLSTGQTGYIPSNYVAP 142 L G+ +++ E +WW + +T + G+ P N V P Sbjct: 35 LRLNPGDIVELTKAEAEHNWWEGRNTATNEVGWFPCNRVHP 75 >1GCP-A nrPDB Length = 70 Score = 35.0 bits (79), Expect = 0.079, Method: Composition-based stats. Identities = 11/41 (26%), Positives = 20/41 (48%), Gaps = 1/41 (2%) Query: 103 LSFKKGERLQIVN-NTEGDWWLAHSLSTGQTGYIPSNYVAP 142 L G+ +++ E +WW + +T + G+ P N V P Sbjct: 27 LRLNPGDIVELTKAEAEHNWWEGRNTATNEVGWFPCNRVHP 67 >3GXW-A nrPDB Length = 103 Score = 33.8 bits (76), Expect = 0.21, Method: Composition-based stats. Identities = 17/99 (17%), Positives = 41/99 (41%), Gaps = 13/99 (13%) Query: 149 EEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIR 208 +YF +++E L + E RG F++R+S ++ + +H I+ Sbjct: 10 HPYYF-PFNGKQAEDYLRSKE--RGDFVIRQSSRGDDHLAITWKLDKDLF----QHVDIQ 62 Query: 209 KLDS------GGFYITSRTQFNSLQQLVAYYSKHADGLC 241 +++ G + +++ L Q++ Y ++ L Sbjct: 63 EMEKENPLAMGKVLVVEGQRYHDLDQIIVEYLQNKIRLL 101 >3LH5-A nrPDB Length = 251 Score = 33.0 bits (74), Expect = 0.30, Method: Composition-based stats. Identities = 19/92 (20%), Positives = 35/92 (38%), Gaps = 14/92 (15%) Query: 84 GGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPS 143 G ++YE + LSF KGE ++V+ +L G+ G +++A Sbjct: 1 GDSFYIRTHFEYEKESPYGLSFNKGEVFRVVD----------TLYNGKLG----SWLAIR 46 Query: 144 DSIQAEEWYFGKITRRESERLLLNAENPRGTF 175 +E G I + L + + + F Sbjct: 47 IGKNHKEVERGIIPNKNRAEQLASVQYVQTKF 78 >3TSW-A nrPDB Length = 391 Score = 32.7 bits (73), Expect = 0.46, Method: Composition-based stats. Identities = 17/61 (27%), Positives = 26/61 (42%), Gaps = 7/61 (11%) Query: 84 GGVTTFVALYDYESRTETDLSFKKGERLQIVN---NTEGDWWLAHSLSTGQ----TGYIP 136 G ++YE + LSF KGE ++V+ N + WLA + G IP Sbjct: 104 GDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIP 163 Query: 137 S 137 + Sbjct: 164 N 164 >6FAI-l nrPDB Length = 425 Score = 32.3 bits (72), Expect = 0.54, Method: Composition-based stats. Identities = 22/169 (13%), Positives = 44/169 (26%), Gaps = 39/169 (23%) Query: 270 LRLEVKLGQGCFGEVWMGTWNGTTRVAIKT-----------------LKPGTMSPE---- 308 + +G G +++ + +K LK Sbjct: 95 YSVGNTIGVGKESDIYKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHL 154 Query: 309 ---AFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQ 365 A +E Q M L + ++ +V E + + L+ Sbjct: 155 SRLAANKEYQFMSMLYSKGF-KVPEPFDNSRHIVVMELIEGYPMR-RLRKHKNIPKLYSD 212 Query: 366 LVDMAAQIASGMAYVERMNYVHRDLRAANILVGE------NLVCKVADF 408 L+ +A +H D NI++ + + V DF Sbjct: 213 LMCFIVDLA-------NSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >3SHW-A nrPDB Length = 468 Score = 32.3 bits (72), Expect = 0.54, Method: Composition-based stats. Identities = 17/61 (27%), Positives = 26/61 (42%), Gaps = 7/61 (11%) Query: 84 GGVTTFVALYDYESRTETDLSFKKGERLQIVN---NTEGDWWLAHSLSTGQ----TGYIP 136 G ++YE + LSF KGE ++V+ N + WLA + G IP Sbjct: 96 GDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIP 155 Query: 137 S 137 + Sbjct: 156 N 156 >5IXB-A nrPDB Length = 108 Score = 32.3 bits (72), Expect = 0.56, Method: Composition-based stats. Identities = 14/75 (18%), Positives = 30/75 (40%), Gaps = 9/75 (12%) Query: 86 VTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDW---WLAH------SLSTGQTGYIP 136 ++ VAL DY + L+ +G+ + + + +G W + GY P Sbjct: 22 ISMAVALQDYMAPDCRFLTIHRGQVVYVFSKLKGRGRLFWGGSVQGDYYGDLAARLGYFP 81 Query: 137 SNYVAPSDSIQAEEW 151 S+ V +++ + Sbjct: 82 SSIVREDQTLKPGKV 96 >4V1O-Q nrPDB Length = 734 Score = 32.3 bits (72), Expect = 0.57, Method: Composition-based stats. Identities = 22/86 (25%), Positives = 28/86 (32%), Gaps = 13/86 (15%) Query: 27 AGGGAFPASQTPS----KPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPL 82 G PAS P+ A A G G S A KL VT + AGP Sbjct: 223 TGSSVPPASPNPASAVENNAVAIGSSGASGTVATDPTNGKLL--------VTKLEDAGPA 274 Query: 83 AGGVTTFVALYDYESRTETDLSFKKG 108 + YD + F++G Sbjct: 275 EDPTKVGMVKYD-GKEVANEPEFEEG 299 >6BWX-A nrPDB Length = 537 Score = 32.3 bits (72), Expect = 0.58, Method: Composition-based stats. Identities = 14/88 (15%), Positives = 28/88 (31%), Gaps = 22/88 (25%) Query: 75 SPQRAGPLAGGVTTFV-------ALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSL 127 +P P + + A++DY + WW + Sbjct: 322 APFSQAPWSTDPQVRLTQGASEKAIFDYNHGDDDP-------------AHRDQWWQNNLP 368 Query: 128 STGQTGYIPSNY--VAPSDSIQAEEWYF 153 TGQT + P N S ++ + + ++ Sbjct: 369 ITGQTNWAPKNAHQANLSSNVPSRQEFW 396 >3NL2-A nrPDB Length = 540 Score = 31.9 bits (71), Expect = 0.68, Method: Composition-based stats. Identities = 15/49 (30%), Positives = 24/49 (48%), Gaps = 3/49 (6%) Query: 281 FGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY 329 +G+V G NG T V ++ + F++EA +K+L H V L Sbjct: 28 YGQVEAGLQNGVTLV---QIREKDADTKFFIEEALQIKELCHAHNVPLI 73 >2GTJ-A nrPDB Length = 96 Score = 31.9 bits (71), Expect = 0.77, Method: Composition-based stats. Identities = 15/42 (35%), Positives = 24/42 (57%), Gaps = 5/42 (11%) Query: 97 SRTETDLSFKKGERLQIV---NNTEGDWWLAHSLSTGQTGYI 135 + +LSFK+GE+++I+ +N EG W + G GYI Sbjct: 38 KGGKNELSFKQGEQIEIIRITDNPEGKWL--GRTARGSYGYI 77 >3NPK-A nrPDB Length = 291 Score = 31.5 bits (70), Expect = 0.95, Method: Composition-based stats. Identities = 7/27 (25%), Positives = 16/27 (59%) Query: 364 PQLVDMAAQIASGMAYVERMNYVHRDL 390 P+L++ A +A + ++ + +H DL Sbjct: 56 PELLNQALDVALALEFIHTYSLIHDDL 82 >1Y1U-A nrPDB Length = 585 Score = 31.5 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 13/47 (27%), Positives = 25/47 (53%), Gaps = 2/47 (4%) Query: 154 GKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGL 200 G + ++++ LL+N P GTFL+R S++ G ++ + L Sbjct: 469 GFVNKQQAHDLLINK--PDGTFLLRFSDSEIGGITIAWKFDSPDRNL 513 >4H05-A nrPDB Length = 273 Score = 31.5 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 15/61 (24%), Positives = 20/61 (32%), Gaps = 5/61 (8%) Query: 381 ERMNYVHRDLRAANILVGEN-----LVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPE 435 E + H DL N+L+ + V G A D R+ A W PE Sbjct: 182 EDLAVCHGDLCPDNVLLDPRTCEVTGLIDVGRVGRADRHSDLALVLRELAHEEDPWFGPE 241 Query: 436 A 436 Sbjct: 242 C 242 >5LJ3-H nrPDB Length = 591 Score = 31.1 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 14/28 (50%), Positives = 19/28 (67%), Gaps = 1/28 (3%) Query: 387 HRDLRAANILVGENLVCK-VADFGLARL 413 HRDL NIL+G +++CK V DF L + Sbjct: 41 HRDLFQVNILIGRDIICKNVVDFTLNKQ 68 >5WLC-SS nrPDB Length = 898 Score = 30.0 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 13/46 (28%), Positives = 22/46 (47%) Query: 157 TRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNV 202 TR E E +L E + L R S+ + ++SD +N + N+ Sbjct: 464 TREEMEEMLRQGERLKAKMLDRNSDDEEDGRVQTLSDVENEEKENI 509 >4GYG-A nrPDB Length = 397 Score = 30.0 bits (66), Expect = 2.6, Method: Composition-based stats. Identities = 25/115 (21%), Positives = 40/115 (34%), Gaps = 29/115 (25%) Query: 309 AFLQEAQVMKKLRHEKLVQLYAVVSEEPI-----YIVTEYMSKGSLLDFLKGETGKYLRL 363 A ++E MK L E EPI IV SL+D L + + Sbjct: 159 AAIKEFAFMKALYEE------GFPVPEPIAQSRHTIVM------SLVDALPMR--QVSSV 204 Query: 364 PQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCK----------VADF 408 P + A + + + + + +H D NIL+ E + + DF Sbjct: 205 PDPASLYADLIALILRLAKHGLIHGDFNEFNILIREEKDAEDPSSITLTPIIIDF 259 >1JFI-B nrPDB Length = 179 Score = 29.2 bits (64), Expect = 4.7, Method: Composition-based stats. Identities = 11/55 (20%), Positives = 22/55 (40%), Gaps = 2/55 (3%) Query: 266 PRESLRLEVKLGQGCF-GEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKK 319 P ++ LG G + EV VA+K K + + E +++++ Sbjct: 71 PEHVIQALESLGFGSYISEVKE-VLQECKTVALKRRKASSRLENLGIPEEELLRQ 124 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.307 0.141 0.406 Lambda K H 0.267 0.0433 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 22,196,172 Number of Sequences: 36641 Number of extensions: 907861 Number of successful extensions: 6912 Number of sequences better than 10.0: 648 Number of HSP's better than 10.0 without gapping: 1028 Number of HSP's successfully gapped in prelim test: 199 Number of HSP's that attempted gapping in prelim test: 2533 Number of HSP's gapped (non-prelim): 1380 length of query: 536 length of database: 10,336,785 effective HSP length: 102 effective length of query: 434 effective length of database: 6,599,403 effective search space: 2864140902 effective search space used: 2864140902 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.0 bits) S2: 62 (28.4 bits)