BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P12081 (509 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4X5O-A nrPDB 1025 0.0 5W6M-A nrPDB 911 0.0 3NET-A nrPDB 222 2e-58 2LW7-A nrPDB 209 2e-54 6NHI-A nrPDB 209 3e-54 4YRG-A nrPDB 158 4e-39 3HRI-A nrPDB 155 5e-38 1WU7-A nrPDB 125 5e-29 1X59-A nrPDB 114 8e-26 5E3I-A nrPDB 93 3e-19 1ADJ-A nrPDB 89 3e-18 1QE0-A nrPDB 88 9e-18 3RAC-A nrPDB 87 2e-17 2EL9-A nrPDB 86 3e-17 3OD1-A nrPDB 80 2e-15 4E51-A nrPDB 76 4e-14 1Z7M-A nrPDB 49 6e-06 6FUA-A nrPDB 39 0.005 1F8S-A nrPDB 36 0.046 3KVE-A nrPDB 35 0.064 2DJV-A nrPDB 33 0.25 1REO-A nrPDB 32 0.88 5XIL-A nrPDB 30 2.5 5Z50-A nrPDB 30 2.9 1SGM-A nrPDB 29 4.8 5Z5E-A nrPDB 29 5.9 3A31-A nrPDB 28 6.9 >4X5O-A nrPDB Length = 509 Score = 1025 bits (2651), Expect = 0.0, Method: Compositional matrix adjust. Identities = 509/509 (100%), Positives = 509/509 (100%) Query: 1 MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPK 60 MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPK Sbjct: 1 MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPK 60 Query: 61 GTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQ 120 GTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQ Sbjct: 61 GTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQ 120 Query: 121 GGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAG 180 GGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAG Sbjct: 121 GGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAG 180 Query: 181 NFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDK 240 NFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDK Sbjct: 181 NFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDK 240 Query: 241 LDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLG 300 LDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLG Sbjct: 241 LDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLG 300 Query: 301 DLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAG 360 DLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAG Sbjct: 301 DLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAG 360 Query: 361 GRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKL 420 GRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKL Sbjct: 361 GRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKL 420 Query: 421 LEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRS 480 LEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRS Sbjct: 421 LEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRS 480 Query: 481 VTSREEVDVRREDLVEEIKRRTGQPLCIC 509 VTSREEVDVRREDLVEEIKRRTGQPLCIC Sbjct: 481 VTSREEVDVRREDLVEEIKRRTGQPLCIC 509 >5W6M-A nrPDB Length = 450 Score = 911 bits (2354), Expect = 0.0, Method: Compositional matrix adjust. Identities = 449/450 (99%), Positives = 450/450 (100%) Query: 54 FVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKL 113 FVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKL Sbjct: 1 FVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKL 60 Query: 114 IYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQ 173 IYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQ Sbjct: 61 IYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQ 120 Query: 174 CDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRT 233 C+FDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRT Sbjct: 121 CEFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRT 180 Query: 234 ICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNK 293 ICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNK Sbjct: 181 ICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNK 240 Query: 294 QALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLG 353 QALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLG Sbjct: 241 QALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLG 300 Query: 354 VGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLV 413 VGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLV Sbjct: 301 VGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLV 360 Query: 414 ASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKD 473 ASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKD Sbjct: 361 ASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKD 420 Query: 474 GVIKLRSVTSREEVDVRREDLVEEIKRRTG 503 GVIKLRSVTSREEVDVRREDLVEEIKRRTG Sbjct: 421 GVIKLRSVTSREEVDVRREDLVEEIKRRTG 450 >3NET-A nrPDB Length = 465 Score = 222 bits (566), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 158/473 (33%), Positives = 249/473 (52%), Gaps = 42/473 (8%) Query: 53 KFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSK 112 K TP G ++ P + + + D I R ++ +G I+TP E E L K + Sbjct: 9 KINFSTPSGFPEFLPSEKRLELYLLDTIRRVYESYGFTPIETPAVERLEVLQAKGNQGDN 68 Query: 113 LIYDLK---------------DQGGELLSLRYDLTVPFARYLA--MNKLT-NIKRYHIAK 154 +IY L+ D G E +L++D TVP A Y+A +N LT RY + Sbjct: 69 IIYGLEPILPPNRQAEKDKSGDTGSEARALKFDQTVPLAAYIARHLNDLTFPFARYQMDV 128 Query: 155 VYRRDNPAMTRGRYREFYQCDFDIAGNFD-PMIPDAECLKIMCEILSSLQIGDFLVKVND 213 V+R + GR+R+F QCD D+ G ++ DA+ I+ EI ++ IGDF++++N+ Sbjct: 129 VFRGER--AKDGRFRQFRQCDIDVVGREKLSLLYDAQMPAIITEIFEAVNIGDFVIRINN 186 Query: 214 RRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQ 273 R++L G F +S+++ ++ S +D L+K+ +VK E+ E G+ PE +I D+V+ Sbjct: 187 RKVLTGFFQSLNISETQIKSCISIIDNLEKIGEAKVKLELEKE-GINPEQTQKIIDFVKI 245 Query: 274 HGGVSLVEQLLQ--DPKLSQNKQALEGLGDLKLLFEYLTLFGIDDK-ISFDLSLARGLDY 330 G V V L+ L +++Q G+ +L+ + + G+ DK DL++ARGL+Y Sbjct: 246 DGSVDDVLDKLKHLSQTLPESEQFNLGVSELETVITGVRNLGVPDKRFCIDLAIARGLNY 305 Query: 331 YTGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIF 390 YTG +YE L+ G E L GS+ +GGRY+ LVG F G K+P VG+SIG+ R+ Sbjct: 306 YTGTVYETTLI------GHEAL--GSICSGGRYEELVGTF--IGEKMPGVGISIGLTRLI 355 Query: 391 SIVEQRL--EALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKL 448 S RL + + T QV+V + Q +L+ LK+ +L AG+ ++K +L Sbjct: 356 S----RLLKAGILNTLPPTPAQVVVVNMQDELMPTYLKVSQQLRQAGLNVITNFEKR-QL 410 Query: 449 LNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRR 501 Q Q ++ GI IIG E L+ + S E+V+V DL EEIKRR Sbjct: 411 GKQFQAADKQGIRFCVIIGADEAAAQKSSLKDLQSGEQVEVALADLAEEIKRR 463 >2LW7-A nrPDB Length = 170 Score = 209 bits (532), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 108/111 (97%), Positives = 108/111 (97%) Query: 399 ALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEA 458 ALEEKIRTTETQVLVASAQKKLLEERLKLVSEL DAGIKAELLYKKNPKLLNQLQYCEEA Sbjct: 60 ALEEKIRTTETQVLVASAQKKLLEERLKLVSELQDAGIKAELLYKKNPKLLNQLQYCEEA 119 Query: 459 GIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQPLCIC 509 GIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQPL I Sbjct: 120 GIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQPLSIS 170 Score = 112 bits (279), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 59/60 (98%), Positives = 59/60 (98%) Query: 2 AERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPKG 61 AERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPK Sbjct: 1 AERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPKA 60 >6NHI-A nrPDB Length = 457 Score = 209 bits (531), Expect = 3e-54, Method: Compositional matrix adjust. Identities = 143/465 (30%), Positives = 265/465 (56%), Gaps = 50/465 (10%) Query: 60 KGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDS-KLIYDLK 118 KGTRD++ ++++ R+ + + + + F+ G + ++TP FE TL GKYGE+ +LI+ + Sbjct: 15 KGTRDFTAQEVSRRKYIINTLQKNFELFGFQPLETPSFENLSTLTGKYGEEGDRLIFKIL 74 Query: 119 DQGG----------------ELLS------LRYDLTVPFARYLAMN--KLT-NIKRYHIA 153 + G +L S LRYDLTVPFAR++AMN +LT KRY I Sbjct: 75 NSGNYTDKVNENDWQNKDAKKLTSQISDKALRYDLTVPFARFVAMNHGQLTFPFKRYQIQ 134 Query: 154 KVYRRDNPAMTRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVND 213 V+R D P +GR+REFYQCD D+ G+ + + + E +++ + L + +++N+ Sbjct: 135 PVWRADRPQ--KGRFREFYQCDADVVGS-ESLWQEVELVQLYFKAFKELGV-PVAIQMNN 190 Query: 214 RRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQ 273 R+IL G+ G+++ + ++DKLDK+ + V EM EKG++ E +++ D++ Sbjct: 191 RKILSGLAEYAGITE-QLIDFTVALDKLDKIGKDGVIKEM-QEKGISNEAIEKL-DFL-F 246 Query: 274 HGGVSLVEQLLQ-DPKLSQNKQALEGLGDLKLLFEYLTLFGIDDK-ISFDLSLARGLDYY 331 H ++ +E L + + + ++G+ +L+ + GID++ + F+++LARGLDYY Sbjct: 247 HQKINALENLQELKTRFEGVEVGIQGVTELEFVLSKAMELGIDNQDLVFNITLARGLDYY 306 Query: 332 TGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFS 391 TG I+E A+ E +GS+ GGRY+ L +F K +P +G+S G++R + Sbjct: 307 TGAIFEV-----KAKGVE----MGSIGGGGRYNNLTEVFGVK--NIPGIGISFGLDRTYL 355 Query: 392 IVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQ 451 ++E+ L + T + + L A+ ++ E +KL+++L + GI AE LY + KL Q Sbjct: 356 VMEEL--GLFPENATVKVEYLFANYGEEEAIEAMKLIAQLREKGISAE-LYPEAAKLKKQ 412 Query: 452 LQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVE 496 Y E+ IP + +G+ E+++ + ++++T+ E+ + + + ++ Sbjct: 413 FTYAEKKEIPNLVFLGKDEIENANVTIKNLTTGEQETITQSEFLK 457 >4YRG-A nrPDB Length = 456 Score = 158 bits (400), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 131/462 (28%), Positives = 224/462 (48%), Gaps = 38/462 (8%) Query: 41 LKAQL-GPDESKQKFVLKTP-KGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFE 98 L+AQ GP ++ V P +G RD+ P M R +FDV K G E D PV E Sbjct: 12 LEAQTQGPGSMQKNMVETEPVQGCRDFPPEAMRCRRHLFDVFHATAKTFGFEEYDAPVLE 71 Query: 99 LKETLMGKYGED-SKLIYDLKDQGGELLSLRYDLTVPFARYL---AMNKLTNIKRYHIAK 154 +E + K GE+ ++ +++ +GG ++LR ++T AR L + L K Y I + Sbjct: 72 SEELYIRKAGEEITEQMFNFITKGGHRVALRPEMTPSLARLLLGKGRSLLLPAKWYSIPQ 131 Query: 155 VYRRDNPAMTRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIG--DFLVKVN 212 +R + A+TRGR RE YQ + DI G + + E + C + SL + D +KVN Sbjct: 132 CWRYE--AITRGRRREHYQWNMDIVG-VKSVSAEVELVCAACWAMRSLGLSSKDVGIKVN 188 Query: 213 DRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQ 272 R++L + GV+ KF +C VDK++K+ EEV+ ++ GL P V D I + Sbjct: 189 SRKVLQTVVEQAGVTSDKFAPVCVIVDKMEKIPREEVEAQL-AVLGLEPTVVDAITTTLS 247 Query: 273 QHGGVSLVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYT 332 + ++++ Q ++ + +A++ +L+ FE + +G D + FD S+ RGL YYT Sbjct: 248 ----LKSIDEIAQ--RVGEEHEAVK---ELRQFFEQVEAYGYGDWVLFDASVVRGLAYYT 298 Query: 333 GVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSI 392 G+++E + +A + GGRYD L+ + +PC G G I + Sbjct: 299 GIVFEGFDREGKFRA---------LCGGGRYDNLLTTYGSP-TPIPCAGFGFGDCVIVEL 348 Query: 393 VEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQL 452 ++++ L I V++ + + L ++ L DAG A+++ K K++ Sbjct: 349 LQEK--RLLPDIPHVVDDVVI-PFDESMRPHALAVLRRLRDAGRSADIILDKK-KVVQAF 404 Query: 453 QYCEEAGIPLVAIIGEQELKDGVIK---LRSVTSREEVDVRR 491 Y + G ++ +E + G ++ LR T +EE R Sbjct: 405 NYADRVGAVRAVLVAPEEWERGEVQVKMLREGTGKEEGGAER 446 >3HRI-A nrPDB Length = 456 Score = 155 bits (391), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 132/457 (28%), Positives = 218/457 (47%), Gaps = 38/457 (8%) Query: 41 LKAQL-GPDESKQKFVLKTP-KGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFE 98 L+AQ GP + V P +G RD+ P M +R+ +FDV ++ G E D+PV E Sbjct: 12 LEAQTQGPGSMQMNMVETEPVQGCRDFPPETMRLRKYLFDVFHSTARKFGFEEYDSPVLE 71 Query: 99 LKETLMGKYGED-SKLIYDLKDQGGELLSLRYDLTVPFARYL---AMNKLTNIKRYHIAK 154 +E + K GE+ ++ +++ +GG ++LR ++T AR L + L K Y I + Sbjct: 72 SEELYIRKAGEEITEQMFNFITKGGHRVALRPEMTPSLARQLLAKGRSLLLPAKWYSIPQ 131 Query: 155 VYRRDNPAMTRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIG--DFLVKVN 212 +R + A+TRGR RE YQ + DI G + + E + C + SL + D VK+N Sbjct: 132 CWRYE--AITRGRRREHYQWNMDIIG-VKSVSSEVELVCAACTAMQSLGLSSKDVGVKIN 188 Query: 213 DRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQ 272 R+IL + GVS KF +C VDK++K+ EEV ++ GL V D I + Sbjct: 189 SRKILQTVVEQAGVSADKFAPVCVIVDKMEKLPREEVVAQLAA-IGLESNVVDAITSTLS 247 Query: 273 QHGGVSLVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYT 332 + ++++ Q ++ + +A+ L D E +G D + FD S+ RGL YYT Sbjct: 248 ----LKTIDEIAQ--RIGEEHEAVRELRDFITQIE---AYGFGDWVIFDASVVRGLAYYT 298 Query: 333 GVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSI 392 G+++E + ++ GGRYD L+ + VPCVG G I + Sbjct: 299 GIVFEGF---------DRDGNFRALCGGGRYDNLLTTYGSP-TAVPCVGFGFGDCVIVEL 348 Query: 393 VEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQL 452 + ++ + L E + LV + + L ++ L DAG A++++ K K++ Sbjct: 349 LNEK-KLLPELHHVVDD--LVIPFDETMRPHALSILRRLRDAGRSADIVFDKK-KVVQAF 404 Query: 453 QYCEEAGIPLVAIIGEQELKDGVIK---LRSVTSREE 486 Y + G ++ E G ++ LR REE Sbjct: 405 NYADRIGALRAVLVAPDEWARGEVRVKMLREGAGREE 441 >1WU7-A nrPDB Length = 434 Score = 125 bits (314), Expect = 5e-29, Method: Compositional matrix adjust. Identities = 119/455 (26%), Positives = 212/455 (46%), Gaps = 59/455 (12%) Query: 60 KGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDS-KLIYDLK 118 +G RD+ P M V + +F + G ID P E + K GE+ + Y Sbjct: 10 RGFRDFYPEDMDVEKFIFKTAEEAAEAFGFRRIDFPSLEYLDLYRIKSGEELLQQTYSFV 69 Query: 119 DQGGELLSLRYDLTVPFARYLAMNKLTN--IKRYHIAKVYRRDNPAMTRGRYREFYQCDF 176 D+GG ++L + T R + K ++ Y KV+R + P GRYRE YQ + Sbjct: 70 DKGGREVTLIPEATPSTVRMVTSRKDLQRPLRWYSFPKVWRYEEPQA--GRYREHYQFNA 127 Query: 177 DIAGNFDPMIPDAECLKIMCEILSSLQIGD-FLVKVNDRRILDGMFAICGVSDSKFRTIC 235 DI G+ P DAE + + IL L + D + +++N R+I++ + I G++ S ++ Sbjct: 128 DIFGSDSPE-ADAEVIALASSILDRLGLQDIYEIRINSRKIMEEI--IGGMTSSDPFSVF 184 Query: 236 SSVDKLDKVSWEEVKNEM----VGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQ 291 S +D+ K+S EE +++ +GE G++ I D G+ + ++ K S+ Sbjct: 185 SIIDRYHKISREEFVDQLRSAGIGEDGVS-----MIADLCSGTRGIDEMARIT--GKSSE 237 Query: 292 NKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEP 351 + + DL L +G+ + + +D S+ RGL YYTG+++EA +A Sbjct: 238 EIARMAAVEDL------LASYGVKN-VRYDFSIVRGLSYYTGIVFEAYDRSGQFRA---- 286 Query: 352 LGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQR--LEALEEKIRTTET 409 + GGRYD L + G VP VG +G + + S++ +R ++ EK Sbjct: 287 -----ILGGGRYDNLASLM--SGESVPAVGFGMG-DAVISLLLKRENVQIPREKKSVYIC 338 Query: 410 QV------LVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLV 463 +V ++ +KL E + + E+ + G+ A QL+Y G Sbjct: 339 RVGKINSSIMNEYSRKLRERGMNVTVEIMERGLSA------------QLKYASAIGADFA 386 Query: 464 AIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEI 498 I GE++L+ GV+ +R++ + + +V + +VE + Sbjct: 387 VIFGERDLERGVVTIRNMYTGSQENVGLDSVVEHL 421 >1X59-A nrPDB Length = 73 Score = 114 bits (286), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 60/60 (100%), Positives = 60/60 (100%) Query: 1 MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPK 60 MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPK Sbjct: 8 MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPK 67 >5E3I-A nrPDB Length = 438 Score = 92.8 bits (229), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 112/450 (24%), Positives = 198/450 (44%), Gaps = 50/450 (11%) Query: 60 KGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLI----Y 115 KG D P Q A ++ + +G + I P+ E G+ + ++ Y Sbjct: 16 KGFNDVLPTQTAAWRRLEQHLASLMDAYGYQQIRLPIVEQTGLFKRAIGDATDIVEKEMY 75 Query: 116 DLKDQGG--ELLSLRYDLTVPFARYLAMNKL---TNIKRYHIAKVYRRDNPAMTRGRYRE 170 D+G E L+LR + T R L + L + +++ ++R + P +GRYR+ Sbjct: 76 TFFDKGNPPESLTLRPEGTAGCVRALVEHNLLRGATPRVWYMGPMFRYEKP--QKGRYRQ 133 Query: 171 FYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSD-- 228 F+Q + G P I DAE + + + + + D +V++ G +D Sbjct: 134 FHQFGVETFGVATPDI-DAELIMLTARLWKRMGV-DHMVQLE--------LNTLGETDER 183 Query: 229 SKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQD-P 287 +++R + K + +E + L RI D + +++L++ P Sbjct: 184 TEYRNALVAFLNEHKDALDEDSQRRLTTNPL------RILD-----SKIESTQKILENAP 232 Query: 288 KLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQA 347 KL + + L + L +YLT GI K + L RGLDYY ++E +Q Sbjct: 233 KLHDFLKE-DSLSHFQQLQDYLTAAGI--KFVINQKLVRGLDYYNKTVFEWTTTALGSQ- 288 Query: 348 GEEPLGVGSVAAGGRYDGLVGMFDPKG-RKVPCVGLSIGVERIFSIVEQRLEALEEKIRT 406 G+V AGGRYDGLVG K + VP VG ++G+ER+ ++EQ +A E +R Sbjct: 289 -------GTVCAGGRYDGLVGQLKGKADQSVPAVGFAMGMERLLLLLEQVEQA--EIVRD 339 Query: 407 TETQVLVASA-QKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAI 465 E ++ A Q K L +L +L A + + +Q++ ++AG I Sbjct: 340 CEAFLVAEPAYQSKALVLAEQLRDQLEAANSNIRIKTGSQGSMKSQMKKADQAGAVYAII 399 Query: 466 IGEQELKDGVIKLRSVTSREEVDVRREDLV 495 +GE+E + + ++ + + E+ V +LV Sbjct: 400 LGEREWEAQQLAVKELATAEQSQVALAELV 429 >1ADJ-A nrPDB Length = 421 Score = 89.4 bits (220), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 111/467 (23%), Positives = 199/467 (42%), Gaps = 93/467 (19%) Query: 60 KGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLI----Y 115 +GT+D +++ + +++ + + GA + TP+FE + G + ++ + Sbjct: 7 RGTKDLFGKELRMHQRIVATARKVLEAAGALELVTPIFEETQVFEKGVGAATDIVRKEMF 66 Query: 116 DLKDQGGELLSLRYDLTVPFARYLAMNKL----TNIKRYHIAKVYRRDNPAMTRGRYREF 171 +D+GG L+LR + T R + + ++ + ++R + P +GRYR+F Sbjct: 67 TFQDRGGRSLTLRPEGTAAMVRAYLEHGMKVWPQPVRLWMAGPMFRAERP--QKGRYRQF 124 Query: 172 YQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVND--------------RRIL 217 +Q +++ G+ +P++ DAE + ++ E L L + VK++ R +L Sbjct: 125 HQVNYEALGSENPIL-DAEAVVLLYECLKELGLRRLKVKLSSVGDPEDRARYNAYLREVL 183 Query: 218 DGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGV 277 DSK R + + LD S E ++ E G+ P + D +G+ + H Sbjct: 184 SPHREALS-EDSKERLEENPMRILDSKS--ERDQALLKELGVRP-MLDFLGEEARAH--- 236 Query: 278 SLVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDL--SLARGLDYYTGVI 335 L + ++ LE L + ++L +L RGLDYY Sbjct: 237 -----------LKEVERHLERL-----------------SVPYELEPALVRGLDYYVRTA 268 Query: 336 YEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQ 395 +E + AQ+ ++ GGRYDGL + G +VP VG + GVER+ +E Sbjct: 269 FEVHHEEIGAQS--------ALGGGGRYDGLSELLG--GPRVPGVGFAFGVERVALALEA 318 Query: 396 RLEALEEK-------IRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNP-K 447 L E+ I TE V A + L RL+ AE Y P K Sbjct: 319 EGFGLPEEKGPDLYLIPLTEEAVAEAFYLAEALRPRLR-----------AE--YALAPRK 365 Query: 448 LLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDL 494 L+ + G +GE EL+ G + L+ + + E+V + RE++ Sbjct: 366 PAKGLEEALKRGAAFAGFLGEDELRAGEVTLKRLATGEQVRLSREEV 412 >1QE0-A nrPDB Length = 420 Score = 87.8 bits (216), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 105/462 (22%), Positives = 193/462 (41%), Gaps = 58/462 (12%) Query: 55 VLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLI 114 ++K P+GT+D P + + + + + I TP+FE + G+ + ++ Sbjct: 1 MIKIPRGTQDILPEDSKKWRYIENQLDELMTFYNYKEIRTPIFESTDLFARGVGDSTDVV 60 Query: 115 ----YDLKDQGGELLSLRYDLTVPFARYLAMNKLTN-----IKRYHIAKVYRRDNPAMTR 165 Y KD+G ++LR + T R +K+ IK Y+ ++R + + Sbjct: 61 QKEMYTFKDKGDRSITLRPEGTAAVVRSYIEHKMQGNPNQPIKLYYNGPMFRYERKQ--K 118 Query: 166 GRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVND-------RRILD 218 GRYR+F Q + G +P + DAE L ++ I S + + +N + + Sbjct: 119 GRYRQFNQFGVEAIGAENPSV-DAEVLAMVMHIYQSFGLKHLKLVINSVGDMASRKEYNE 177 Query: 219 GMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVS 278 + +F + C S D + + K V A + A RI D++ + + Sbjct: 178 ALVKHFEPVIHEFCSDCQSRLHTDPMRILDCK---VDRDKEAIKTAPRITDFLNEESK-A 233 Query: 279 LVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEA 338 EQ+ YL GI + D +L RGLDYYT +E Sbjct: 234 YYEQVKA----------------------YLDDLGI--PYTEDPNLVRGLDYYTHTAFE- 268 Query: 339 VLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLE 398 +++ P G + ++ GGRY+GL+ + D LSI + E Sbjct: 269 LMMDNPNYDG----AITTLCGGGRYNGLLELLDGPSETGIGFALSIERLLLALEEEGIEL 324 Query: 399 ALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEA 458 +EE + + + + + +KL++ L GIKA+ Y + K+ Q++ + Sbjct: 325 DIEENL-----DLFIVTMGDQADRYAVKLLNHLRHNGIKADKDYLQR-KIKGQMKQADRL 378 Query: 459 GIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKR 500 G +IG+QEL++ I ++++T+ E + + LVE K+ Sbjct: 379 GAKFTIVIGDQELENNKIDVKNMTTGESETIELDALVEYFKK 420 >3RAC-A nrPDB Length = 373 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 98/372 (26%), Positives = 173/372 (46%), Gaps = 42/372 (11%) Query: 49 ESKQKFVLKTP---KGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLM- 104 E+ + F + P G D++ R+ AV ++ + + G E + + +FE +TL+ Sbjct: 17 EAVRGFADRPPGMQDGYPDFAKRRRAVETRLLSFV----EDAGYEPVTSGLFEYVDTLLR 72 Query: 105 GKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLA---MNKLTNIKRYHIAKVYRR-DN 160 + E S+ L D GG+ ++LR ++T AR A T I+ + +VYRR D+ Sbjct: 73 ARSPESSRDWIRLFDGGGDAVALRPEMTPSIARMAAPRVAAGRTPIRWCYCERVYRRTDD 132 Query: 161 PA---MTRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRIL 217 PA G+ E Q + G + D + L+++ E ++ + + V+ R++ Sbjct: 133 PASLSWASGKAAESTQVGIERIGEEASVDVDMDVLRLLHEASAAAGVRHHRIVVSHARLV 192 Query: 218 DGMFAICGVSDSKFRTICSSVDKLDKVSWEEV------KNEMVGEKGLAPEVADRIGDYV 271 + G+S S R + + + V + E+ K+ + L A+R Sbjct: 193 PRLLDALGISASLSRAFLACLTSGNYVQFRELWQLHAAKDVDLLANLLTWSPAERDAAKR 252 Query: 272 QQHGGVSLVEQLLQD---PKLSQNKQALEGLGDLKLLFEYLTLFGI-DDKISFDLSLARG 327 + +E LL+D P+ + + + + L L E L G+ D ++FDL+L R Sbjct: 253 SREASDRELEALLRDAVDPRAAADVR--DAWRYLCRLAEALHDSGLASDVVTFDLALHRE 310 Query: 328 LDYYTGVIYEAVLLQTPAQAGEEPLGVGS-VAAGGRYDGLVGMFDPKGRKVPCVGLSIGV 386 LDYYTG+++E + P GVG+ +A GGRYD L+ F G P VG + V Sbjct: 311 LDYYTGLVFE---MFAP--------GVGAPIAQGGRYDELLAQF---GAGAPAVGFAFEV 356 Query: 387 ERIFSIVEQRLE 398 ER+ +++E + E Sbjct: 357 ERVMAVLEAQEE 368 >2EL9-A nrPDB Length = 431 Score = 86.3 bits (212), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 112/470 (23%), Positives = 200/470 (42%), Gaps = 80/470 (17%) Query: 60 KGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLI----Y 115 +G DY P + A+ +++ + +G I P+ E GE + ++ Y Sbjct: 16 RGMNDYLPGETAIWQRIEGTLKNVLGSYGYSEIRLPIVEQTPLFKRAIGEVTDVVEKEMY 75 Query: 116 DLKDQGGELLSLRYDLTVPFARY-LAMNKLTNIKR--YHIAKVYRRDNPAMTRGRYREFY 172 +D+ G+ L+LR + T R + L N ++ ++I ++R + P +GRYR+F+ Sbjct: 76 TFEDRNGDSLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFRHERP--QKGRYRQFH 133 Query: 173 QCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFL-VKVNDRRILDGMFAICGVSDSKF 231 Q ++ G P I DAE + + +L I + + +++N + + A D+ Sbjct: 134 QLGCEVFGLQGPDI-DAELIMLTARWWRALGISEHVTLELNS---IGSLEARANYRDALV 189 Query: 232 RTICSSVDKLDKVSWEEVKNEMVGEK-----GLAPEV------ADRIGDYVQQHGGVSLV 280 + +KLD E+ K M PEV A +GDY+ + Sbjct: 190 AFLEQHKEKLD----EDCKRRMYTNPLRVLDSKNPEVQALLNDAPALGDYLDE------- 238 Query: 281 EQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVL 340 ++++ GL KLL + ++ + L RGLDYY ++E V Sbjct: 239 ----------ESREHFAGL--CKLLESAGIAYTVNQR------LVRGLDYYNRTVFEWVT 280 Query: 341 LQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEAL 400 +Q G+V AGGRYDGLV GR P VG ++G+ER+ +V +A+ Sbjct: 281 NSLGSQ--------GTVCAGGRYDGLVEQLG--GRATPAVGFAMGLERLVLLV----QAV 326 Query: 401 EEKIRTTETQ--VLVAS-----AQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQ 453 + + LVAS + L ERL+ EL G+K + Q Sbjct: 327 NPEFKADPVVDIYLVASGADTQSAAMALAERLR--DEL--PGVKL-MTNHGGGNFKKQFA 381 Query: 454 YCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTG 503 ++ G + ++GE E+ +G ++ + S E+ V ++ + ++ G Sbjct: 382 RADKWGARVAVVLGESEVANGTAVVKDLRSGEQTAVAQDSVAAHLRTLLG 431 >3OD1-A nrPDB Length = 400 Score = 80.1 bits (196), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 82/342 (23%), Positives = 146/342 (42%), Gaps = 36/342 (10%) Query: 54 FVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKL 113 F+ + P G RD P ++ + D + G ++I+TP E ET+ + Sbjct: 8 FMFEKPFGMRDTLPEWYKTKKNICDQMTEEINLWGYDMIETPTLEYYETVGVVSAILDQQ 67 Query: 114 IYDLKDQGGELLSLRYDLTVPFARYLAM---NKLTNIKRYHIAKVYRRDNPAMTRGRYRE 170 ++ L DQ G L LR D+T P AR +A ++ ++ + + VYR G+ E Sbjct: 68 LFKLLDQQGNTLVLRPDMTAPIARLVASSLKDRAYPLRLAYQSNVYRAQQN--EGGKPAE 125 Query: 171 FYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSK 230 F Q ++ G+ D E + +M L + +F V + ++ + ++ + Sbjct: 126 FEQLGVELIGD-GTASADGEVIALMIAALKRAGLSEFKVAIGHVGYVNALLMDVVGNEQR 184 Query: 231 FRTICSSVDKLDKVSWEEVKN-----EMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQ 285 D+L + +E KN E V L+ R+ + + GG + +E+ Sbjct: 185 -------ADRLRRFLYE--KNYVGYREHVKSLNLSTIDKSRLMNLLSLRGGRAAIEEA-- 233 Query: 286 DPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPA 345 L Q ++ L ++ L+E L +G + + FDL+L + YYTGV++E Sbjct: 234 -RGLIQTEKGKTALAEMTKLYEVLESYGASEYVKFDLTLVLHMSYYTGVVFEGY------ 286 Query: 346 QAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVE 387 LGV + +GGRYD L+ F R G + ++ Sbjct: 287 ---GNRLGV-PLCSGGRYDELLSKFH---RPAQATGFGVRID 321 >4E51-A nrPDB Length = 467 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 102/443 (23%), Positives = 189/443 (42%), Gaps = 69/443 (15%) Query: 60 KGTRDYSPRQMAVREKVFDVIIRCFKR-HGAEVIDTPVFELKETLMGKYGEDSKLI---- 114 KG D P+ + E F+ ++ R +G + I TP+ E GE + ++ Sbjct: 36 KGMNDILPQDAGLWE-FFEATVKSLLRAYGYQNIRTPIVEHTPLFTRGIGEVTDIVEKEM 94 Query: 115 YDLKDQ-GGELLSLRYDLTVPFARY-LAMNKLTNIKR--YHIAKVYRRDNPAMTRGRYRE 170 Y D GE L+LR + T R + N L + + ++I ++R + P RGRYR+ Sbjct: 95 YSFVDALNGENLTLRPENTAAVVRAAIEHNMLYDGPKRLWYIGPMFRHERP--QRGRYRQ 152 Query: 171 FYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSK 230 F+Q + G P DAE + + + L + +++N G+++ + Sbjct: 153 FHQVGVEALGFAGP-DADAEIVMMCQRLWEDLGLTGIKLEINS----------LGLAEER 201 Query: 231 FRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQL-LQDPKL 289 + +++ + + E + AD++ D Q+ + + L ++P L Sbjct: 202 ------AAHRVELIKYLE-------------QHADKLDDDAQRRLYTNPLRVLDTKNPAL 242 Query: 290 SQ----NKQALEGLGDL-KLLFEYLTLFGIDDKISFDLS--LARGLDYYTGVIYEAVLLQ 342 + + ++ LGD+ + FE L + + F ++ L RGLDYY ++E V + Sbjct: 243 QEIVRNAPKLIDFLGDVSRAHFEGLQRLLKANNVPFTINPRLVRGLDYYNLTVFEWVTDK 302 Query: 343 TPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIV-EQRLEALE 401 AQ G+VAAGGRYD L+ G+ G ++G+ERI ++ E+ L + Sbjct: 303 LGAQ--------GTVAAGGRYDPLIEQL--GGKPTAACGWAMGIERILELLKEEHLVPEQ 352 Query: 402 EKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKN---PKLLNQLQYCEEA 458 E + V V E+ + L D G+ L + +Q++ + + Sbjct: 353 EGV-----DVYVVHQGDAAREQAFIVAERLRDTGLDVILHCSADGAGASFKSQMKRADAS 407 Query: 459 GIPLVAIIGEQELKDGVIKLRSV 481 G I GE E+ +G ++ + Sbjct: 408 GAAFAVIFGEDEVTNGTASVKPL 430 >1Z7M-A nrPDB Length = 344 Score = 48.9 bits (115), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 61/270 (22%), Positives = 116/270 (42%), Gaps = 35/270 (12%) Query: 105 GKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRY-HIAKVYRRDNPAM 163 GK K+ +K +G + ++LRYD T+P R + K + RY + K++R++ Sbjct: 76 GKTFNQEKMFQFIKHEG-QSITLRYDFTLPLVRLYSQIKDSTSARYSYFGKIFRKEKRH- 133 Query: 164 TRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAI 223 +GR E YQ ++ G + E L + +++ L + + ++ + + Sbjct: 134 -KGRSTENYQIGIELFGE-SADKSELEILSLALQVIEQLGLNKTVFEIGSAKFFQ---RL 188 Query: 224 CGVSDSKFRTICSSVDKLDKVSWEEV--KNEMVGE-KGLAPEVADRIGDYVQQHGGVSLV 280 C ++D + + K D KN E +GL E+ ++ +S + Sbjct: 189 CQLADGSTELLTELLLKKDLSGLNAFIEKNNFSKELRGLLKEI------FITNE--LSRL 240 Query: 281 EQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVL 340 E L+ + K + + LK E L++ I DL + +DYYT ++++A Sbjct: 241 ENLVTNTK---DDVLISSFDQLKEFSEKLSMI---KPIIIDLGMVPKMDYYTDLMFKAY- 293 Query: 341 LQTPAQAGEEPLGVGSVAAGGRYDGLVGMF 370 + A +P + +GGRYD L+ F Sbjct: 294 ----SSAANQP-----ILSGGRYDQLLSNF 314 >6FUA-A nrPDB Length = 388 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 73/345 (21%), Positives = 144/345 (41%), Gaps = 43/345 (12%) Query: 59 PKGTRDY----SPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSK-L 113 P G D + +Q +R ++ +I HG +++ P+ E E+L+ ED K Sbjct: 4 PDGVADVLFEDAHKQEVLRHQLTQQLIT----HGYQLVSPPMIEFTESLLSGASEDLKRQ 59 Query: 114 IYDLKDQ-GGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFY 172 + + DQ G L+ +R D+T R A + I RY A P+ G R Sbjct: 60 TFKIIDQLTGRLMGIRADITPQILRIDAHHGGDGIARYCYAGDVIHTLPSGLFGS-RTPL 118 Query: 173 QCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFL-VKVNDRRILDGMFAICGVSDSKF 231 Q +I G + + D E + ++ +++SL + L V + I + + +S Sbjct: 119 QLGAEIFG-CESIAADIELIDVLFSMINSLDMSAVLHVDLGHVTIFKRLAELAALS---- 173 Query: 232 RTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVAD-----RIGDYVQQHGGVSLVEQLLQD 286 S ++L ++ + E+ + P +D R G H +L+ +L ++ Sbjct: 174 ---ASDTEQLMQLYANKNLPELKQVCQVLPMGSDFYTLARFG-----HDIANLLGRLSEN 225 Query: 287 PKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQ 346 + Q+ + + + +L+ L +L + +S D++ G Y+TG+++ + Sbjct: 226 AQ--QDTKIVTAIDELQRLKAHLQV-QWQCAVSIDVTELSGYHYHTGIVFNGYI-----N 277 Query: 347 AGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFS 391 + +PL GGR+DG+ + G S+ V R+ + Sbjct: 278 SETQPL-----VRGGRFDGMKSNQLATNQPRQATGFSMDVSRLLA 317 >1F8S-A nrPDB Length = 498 Score = 35.8 bits (81), Expect = 0.046, Method: Compositional matrix adjust. Identities = 33/121 (27%), Positives = 54/121 (44%), Gaps = 13/121 (10%) Query: 232 RTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGG--VSLVEQLLQDPKL 289 RT CS + L+K K ++ E L+P D IGD + + G VS +E L D Sbjct: 170 RTNCSYI--LNKYDTYSTKEYLIKEGDLSPGAVDMIGDLLNEDSGYYVSFIESLKHDDIF 227 Query: 290 SQNK---QALEGLGDLKLLFEYLTLFGIDDKISFDLSLAR--GLDYYTGVIYEAVLLQTP 344 + K + ++G+ L I DK+ F+ + + D V+YE + +TP Sbjct: 228 AYEKRFDEIVDGMDKLPTAM----YRDIQDKVHFNAQVIKIQQNDQKVTVVYETLSKETP 283 Query: 345 A 345 + Sbjct: 284 S 284 >3KVE-A nrPDB Length = 486 Score = 35.4 bits (80), Expect = 0.064, Method: Compositional matrix adjust. Identities = 33/115 (28%), Positives = 51/115 (44%), Gaps = 8/115 (6%) Query: 232 RTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGG--VSLVEQLLQDPKL 289 RT CS + L+K K ++ E L+P D IGD + + G VS +E L D Sbjct: 170 RTNCSYI--LNKYDTYSTKEYLIKEGNLSPGAVDMIGDLLNEDSGYYVSFIESLKHDDIF 227 Query: 290 SQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTP 344 + K+ E +G + L + I++K+ F+ AR + V QTP Sbjct: 228 AYEKRFDEIVGGMDQLPTSMYR-AIEEKVKFN---ARVIKIQQNANQVTVTYQTP 278 >2DJV-A nrPDB Length = 79 Score = 33.5 bits (75), Expect = 0.25, Method: Compositional matrix adjust. Identities = 24/48 (50%), Positives = 29/48 (60%), Gaps = 1/48 (2%) Query: 4 RAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESK 51 +A ++E+ K QG VR LK QKA + EVAKLL LK QL E K Sbjct: 16 QALMDEVTK-QGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGK 62 >1REO-A nrPDB Length = 486 Score = 31.6 bits (70), Expect = 0.88, Method: Compositional matrix adjust. Identities = 24/76 (31%), Positives = 35/76 (46%), Gaps = 4/76 (5%) Query: 232 RTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGG--VSLVEQLLQDPKL 289 RT CS + L+K K ++ E L+P D IGD + + G VS E L D Sbjct: 170 RTNCSYI--LNKYDTYSTKEYLLKEGNLSPGAVDMIGDLMNEDSGYYVSFPESLRHDDIF 227 Query: 290 SQNKQALEGLGDLKLL 305 + K+ E +G + L Sbjct: 228 AYEKRFDEIVGGMDKL 243 >5XIL-A nrPDB Length = 512 Score = 30.0 bits (66), Expect = 2.5, Method: Compositional matrix adjust. Identities = 29/119 (24%), Positives = 51/119 (42%), Gaps = 12/119 (10%) Query: 381 GLSIGVERIFSIVEQRLEALEEKIRTTETQVLVAS----------AQKKLLEERLKLVSE 430 GLS V + +V + R TQV++ A+++LL +L SE Sbjct: 263 GLSTRVIGVMIMVHGDNRGMVMPPRVASTQVIIIPVGITKDTTEEARQELLASCWRLESE 322 Query: 431 LWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDG--VIKLRSVTSREEV 487 L + G++A + N + + E G+PL +G +EL + + +R +R V Sbjct: 323 LCEGGVRARCDLRDNYSPGWRFNHWEVKGVPLRVELGPRELAERSLAVAVRHSGARHSV 381 >5Z50-A nrPDB Length = 237 Score = 29.6 bits (65), Expect = 2.9, Method: Compositional matrix adjust. Identities = 22/63 (34%), Positives = 30/63 (47%), Gaps = 10/63 (15%) Query: 251 NEMVGEKGLAPEV------ADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLGDLKL 304 +E ++GL P+V AD I YV+ GV +V + DPKL + L D Sbjct: 121 DEAFSQRGLVPKVVFTAADADVIKTYVRLGLGVGIVAHMAVDPKLDNDLVIL----DASH 176 Query: 305 LFE 307 LFE Sbjct: 177 LFE 179 >1SGM-A nrPDB Length = 191 Score = 29.3 bits (64), Expect = 4.8, Method: Compositional matrix adjust. Identities = 18/51 (35%), Positives = 25/51 (49%), Gaps = 6/51 (11%) Query: 231 FRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQ--HGGVSL 279 RT+C V K SWE V + E G A E A+++G + GG+ L Sbjct: 120 LRTVCMKVFK----SWEAVFARKLMENGFAEEEANQLGTLINSMIEGGIML 166 >5Z5E-A nrPDB Length = 534 Score = 28.9 bits (63), Expect = 5.9, Method: Compositional matrix adjust. Identities = 13/44 (29%), Positives = 24/44 (54%) Query: 455 CEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEI 498 +E G+P I Q L+D + +R + ++V V+ EDL ++ Sbjct: 486 VDEIGVPYAITIDYQTLEDNTVTIRDRDTMKQVRVKIEDLPNQL 529 >3A31-A nrPDB Length = 471 Score = 28.5 bits (62), Expect = 6.9, Method: Compositional matrix adjust. Identities = 48/246 (19%), Positives = 99/246 (40%), Gaps = 41/246 (16%) Query: 51 KQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETL----MGK 106 ++F T G +S +R + +V+ + R G V++TP+ E + Sbjct: 30 NREFATFTGAGVPLFSLGGGPIRYALAEVLAKFHARRGYYVVETPIIASTELFKVSGHIE 89 Query: 107 YGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTN--------IKRYHIAKVYRR 158 + ++ ++D++ G +++ + P+ L +N++ K + +V+R Sbjct: 90 FYRNNMYLFDIE---GHEFAVK-PMNCPYHILLFLNEVAKHRSKLPLPFKVFEFGRVHRY 145 Query: 159 DNPAMTRG--RYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRI 216 + G R R F Q D I ++P + ++ ++ +++ + Sbjct: 146 EPSGSIYGLLRVRGFTQDDAHI------IVPGGRVIDVVYDVFEEMKL-----------V 188 Query: 217 LDGMFAICGVSDSKFRTICSSVDK-LDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHG 275 L+ +F + GVS F+ S DK L + K E G + E A RI + Sbjct: 189 LERLFKL-GVSSETFKVRLSMSDKSLIGKEFMGSKEEWEGAEEALREAASRI----NEKY 243 Query: 276 GVSLVE 281 G+ +VE Sbjct: 244 GIDIVE 249 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 4X5O-A nrPDB 650 0.0 5W6M-A nrPDB 550 e-157 4YRG-A nrPDB 415 e-116 3HRI-A nrPDB 414 e-116 3NET-A nrPDB 396 e-110 1QE0-A nrPDB 374 e-104 6NHI-A nrPDB 359 2e-99 1WU7-A nrPDB 356 2e-98 2EL9-A nrPDB 354 6e-98 5E3I-A nrPDB 352 2e-97 4E51-A nrPDB 342 2e-94 1ADJ-A nrPDB 281 6e-76 3OD1-A nrPDB 275 2e-74 3RAC-A nrPDB 271 6e-73 1Z7M-A nrPDB 188 5e-48 2LW7-A nrPDB 119 4e-27 1X59-A nrPDB 98 7e-21 Sequences not found previously or not previously below threshold: 6FUA-A nrPDB 116 2e-26 2I4O-A nrPDB 68 1e-11 1NYR-A nrPDB 66 4e-11 1USY-C nrPDB 54 1e-07 1NJ8-A nrPDB 47 2e-05 6JP2-A nrPDB 47 2e-05 3A31-A nrPDB 47 2e-05 6NAB-A nrPDB 44 2e-04 5Z5E-A nrPDB 43 2e-04 4K87-A nrPDB 43 2e-04 6MN8-A nrPDB 42 8e-04 1B76-A nrPDB 41 0.001 1NJ2-A nrPDB 41 0.001 5W25-A nrPDB 41 0.002 1ATI-A nrPDB 41 0.002 4P3N-A nrPDB 40 0.002 3WRZ-A nrPDB 40 0.003 3VQX-A nrPDB 39 0.005 1IL2-A nrPDB 38 0.010 5XIL-A nrPDB 38 0.012 4WJ3-M nrPDB 37 0.022 4RMF-A nrPDB 37 0.025 2ZNJ-A nrPDB 36 0.029 1WLE-A nrPDB 36 0.031 2DU7-A nrPDB 36 0.060 5XIP-A nrPDB 35 0.090 2DJV-A nrPDB 35 0.10 5XIG-A nrPDB 34 0.12 2ODR-C nrPDB 33 0.37 6M7Z-A nrPDB 32 0.41 1CRU-A nrPDB 32 0.49 4NCX-A nrPDB 32 0.53 5IJN-G nrPDB 31 1.1 3A74-A nrPDB 31 1.9 5ZG8-A nrPDB 30 2.2 6OTE-A nrPDB 30 2.4 3MMP-A nrPDB 29 6.1 5OQL-Y nrPDB 28 7.7 >4X5O-A nrPDB Length = 509 Score = 650 bits (1677), Expect = 0.0, Method: Composition-based stats. Identities = 509/509 (100%), Positives = 509/509 (100%) Query: 1 MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPK 60 MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPK Sbjct: 1 MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPK 60 Query: 61 GTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQ 120 GTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQ Sbjct: 61 GTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQ 120 Query: 121 GGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAG 180 GGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAG Sbjct: 121 GGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAG 180 Query: 181 NFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDK 240 NFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDK Sbjct: 181 NFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDK 240 Query: 241 LDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLG 300 LDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLG Sbjct: 241 LDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLG 300 Query: 301 DLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAG 360 DLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAG Sbjct: 301 DLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAG 360 Query: 361 GRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKL 420 GRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKL Sbjct: 361 GRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKL 420 Query: 421 LEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRS 480 LEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRS Sbjct: 421 LEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRS 480 Query: 481 VTSREEVDVRREDLVEEIKRRTGQPLCIC 509 VTSREEVDVRREDLVEEIKRRTGQPLCIC Sbjct: 481 VTSREEVDVRREDLVEEIKRRTGQPLCIC 509 >5W6M-A nrPDB Length = 450 Score = 550 bits (1417), Expect = e-157, Method: Composition-based stats. Identities = 449/450 (99%), Positives = 450/450 (100%) Query: 54 FVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKL 113 FVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKL Sbjct: 1 FVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKL 60 Query: 114 IYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQ 173 IYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQ Sbjct: 61 IYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQ 120 Query: 174 CDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRT 233 C+FDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRT Sbjct: 121 CEFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRT 180 Query: 234 ICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNK 293 ICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNK Sbjct: 181 ICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNK 240 Query: 294 QALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLG 353 QALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLG Sbjct: 241 QALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLG 300 Query: 354 VGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLV 413 VGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLV Sbjct: 301 VGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLV 360 Query: 414 ASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKD 473 ASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKD Sbjct: 361 ASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKD 420 Query: 474 GVIKLRSVTSREEVDVRREDLVEEIKRRTG 503 GVIKLRSVTSREEVDVRREDLVEEIKRRTG Sbjct: 421 GVIKLRSVTSREEVDVRREDLVEEIKRRTG 450 >4YRG-A nrPDB Length = 456 Score = 415 bits (1067), Expect = e-116, Method: Composition-based stats. Identities = 128/462 (27%), Positives = 222/462 (48%), Gaps = 38/462 (8%) Query: 41 LKAQL-GPDESKQKFVLKTP-KGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFE 98 L+AQ GP ++ V P +G RD+ P M R +FDV K G E D PV E Sbjct: 12 LEAQTQGPGSMQKNMVETEPVQGCRDFPPEAMRCRRHLFDVFHATAKTFGFEEYDAPVLE 71 Query: 99 LKETLMGKYGED-SKLIYDLKDQGGELLSLRYDLTVPFARYL---AMNKLTNIKRYHIAK 154 +E + K GE+ ++ +++ +GG ++LR ++T AR L + L K Y I + Sbjct: 72 SEELYIRKAGEEITEQMFNFITKGGHRVALRPEMTPSLARLLLGKGRSLLLPAKWYSIPQ 131 Query: 155 VYRRDNPAMTRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIG--DFLVKVN 212 +R + A+TRGR RE YQ + DI G + + E + C + SL + D +KVN Sbjct: 132 CWRYE--AITRGRRREHYQWNMDIVG-VKSVSAEVELVCAACWAMRSLGLSSKDVGIKVN 188 Query: 213 DRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQ 272 R++L + GV+ KF +C VDK++K+ EEV+ ++ GL P V D I + Sbjct: 189 SRKVLQTVVEQAGVTSDKFAPVCVIVDKMEKIPREEVEAQL-AVLGLEPTVVDAITTTLS 247 Query: 273 QHGGVSLVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYT 332 + ++++ Q ++ + + + +L+ FE + +G D + FD S+ RGL YYT Sbjct: 248 ----LKSIDEIAQ--RVGEEHE---AVKELRQFFEQVEAYGYGDWVLFDASVVRGLAYYT 298 Query: 333 GVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSI 392 G+++E + +A + GGRYD L+ + +PC G G I + Sbjct: 299 GIVFEGFDREGKFRA---------LCGGGRYDNLLTTYGSP-TPIPCAGFGFGDCVIVEL 348 Query: 393 VEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQL 452 ++++ L I V++ + + L ++ L DAG A+++ K K++ Sbjct: 349 LQEK--RLLPDIPHVVDDVVI-PFDESMRPHALAVLRRLRDAGRSADIILDKK-KVVQAF 404 Query: 453 QYCEEAGIPLVAIIGEQELKDGVIKLR---SVTSREEVDVRR 491 Y + G ++ +E + G ++++ T +EE R Sbjct: 405 NYADRVGAVRAVLVAPEEWERGEVQVKMLREGTGKEEGGAER 446 >3HRI-A nrPDB Length = 456 Score = 414 bits (1064), Expect = e-116, Method: Composition-based stats. Identities = 128/462 (27%), Positives = 218/462 (47%), Gaps = 38/462 (8%) Query: 41 LKAQL-GPDESKQKFVLKTP-KGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFE 98 L+AQ GP + V P +G RD+ P M +R+ +FDV ++ G E D+PV E Sbjct: 12 LEAQTQGPGSMQMNMVETEPVQGCRDFPPETMRLRKYLFDVFHSTARKFGFEEYDSPVLE 71 Query: 99 LKETLMGKYGED-SKLIYDLKDQGGELLSLRYDLTVPFARYL---AMNKLTNIKRYHIAK 154 +E + K GE+ ++ +++ +GG ++LR ++T AR L + L K Y I + Sbjct: 72 SEELYIRKAGEEITEQMFNFITKGGHRVALRPEMTPSLARQLLAKGRSLLLPAKWYSIPQ 131 Query: 155 VYRRDNPAMTRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIG--DFLVKVN 212 +R + A+TRGR RE YQ + DI G + + E + C + SL + D VK+N Sbjct: 132 CWRYE--AITRGRRREHYQWNMDIIG-VKSVSSEVELVCAACTAMQSLGLSSKDVGVKIN 188 Query: 213 DRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQ 272 R+IL + GVS KF +C VDK++K+ EEV ++ GL V D I + Sbjct: 189 SRKILQTVVEQAGVSADKFAPVCVIVDKMEKLPREEVVAQL-AAIGLESNVVDAITSTLS 247 Query: 273 QHGGVSLVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYT 332 + ++++ Q ++ + + + +L+ + +G D + FD S+ RGL YYT Sbjct: 248 ----LKTIDEIAQ--RIGEEHE---AVRELRDFITQIEAYGFGDWVIFDASVVRGLAYYT 298 Query: 333 GVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSI 392 G+++E +A + GGRYD L+ + VPCVG G I + Sbjct: 299 GIVFEGFDRDGNFRA---------LCGGGRYDNLLTTYGSP-TAVPCVGFGFGDCVIVEL 348 Query: 393 VEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQL 452 + ++ L ++ LV + + L ++ L DAG A++++ K K++ Sbjct: 349 LNEKK--LLPELHHVVDD-LVIPFDETMRPHALSILRRLRDAGRSADIVFDKK-KVVQAF 404 Query: 453 QYCEEAGIPLVAIIGEQELKDGVIKLR---SVTSREEVDVRR 491 Y + G ++ E G ++++ REE R Sbjct: 405 NYADRIGALRAVLVAPDEWARGEVRVKMLREGAGREEGANER 446 >3NET-A nrPDB Length = 465 Score = 396 bits (1016), Expect = e-110, Method: Composition-based stats. Identities = 151/472 (31%), Positives = 245/472 (51%), Gaps = 38/472 (8%) Query: 53 KFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSK 112 K TP G ++ P + + + D I R ++ +G I+TP E E L K + Sbjct: 9 KINFSTPSGFPEFLPSEKRLELYLLDTIRRVYESYGFTPIETPAVERLEVLQAKGNQGDN 68 Query: 113 LIYDLK---------------DQGGELLSLRYDLTVPFARYLAMN---KLTNIKRYHIAK 154 +IY L+ D G E +L++D TVP A Y+A + RY + Sbjct: 69 IIYGLEPILPPNRQAEKDKSGDTGSEARALKFDQTVPLAAYIARHLNDLTFPFARYQMDV 128 Query: 155 VYRRDNPAMTRGRYREFYQCDFDIAGNFD-PMIPDAECLKIMCEILSSLQIGDFLVKVND 213 V+R + GR+R+F QCD D+ G ++ DA+ I+ EI ++ IGDF++++N+ Sbjct: 129 VFRGER--AKDGRFRQFRQCDIDVVGREKLSLLYDAQMPAIITEIFEAVNIGDFVIRINN 186 Query: 214 RRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQ 273 R++L G F +S+++ ++ S +D L+K+ +VK E+ E G+ PE +I D+V+ Sbjct: 187 RKVLTGFFQSLNISETQIKSCISIIDNLEKIGEAKVKLELEKE-GINPEQTQKIIDFVKI 245 Query: 274 HGGVSLVEQLLQ--DPKLSQNKQALEGLGDLKLLFEYLTLFGIDDK-ISFDLSLARGLDY 330 G V V L+ L +++Q G+ +L+ + + G+ DK DL++ARGL+Y Sbjct: 246 DGSVDDVLDKLKHLSQTLPESEQFNLGVSELETVITGVRNLGVPDKRFCIDLAIARGLNY 305 Query: 331 YTGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIF 390 YTG +YE L+ A +GS+ +GGRY+ LVG F G K+P VG+SIG+ R+ Sbjct: 306 YTGTVYETTLIGHEA--------LGSICSGGRYEELVGTF--IGEKMPGVGISIGLTRLI 355 Query: 391 SIVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLN 450 S + + + + T QV+V + Q +L+ LK+ +L AG+ ++K +L Sbjct: 356 SRLLK--AGILNTLPPTPAQVVVVNMQDELMPTYLKVSQQLRQAGLNVITNFEKR-QLGK 412 Query: 451 QLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRT 502 Q Q ++ GI IIG E L+ + S E+V+V DL EEIKRR Sbjct: 413 QFQAADKQGIRFCVIIGADEAAAQKSSLKDLQSGEQVEVALADLAEEIKRRL 464 >1QE0-A nrPDB Length = 420 Score = 374 bits (961), Expect = e-104, Method: Composition-based stats. Identities = 103/462 (22%), Positives = 190/462 (41%), Gaps = 58/462 (12%) Query: 55 VLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLI 114 ++K P+GT+D P + + + + + I TP+FE + G+ + ++ Sbjct: 1 MIKIPRGTQDILPEDSKKWRYIENQLDELMTFYNYKEIRTPIFESTDLFARGVGDSTDVV 60 Query: 115 ----YDLKDQGGELLSLRYDLTVPFARYLAMNKL-----TNIKRYHIAKVYRRDNPAMTR 165 Y KD+G ++LR + T R +K+ IK Y+ ++R + + Sbjct: 61 QKEMYTFKDKGDRSITLRPEGTAAVVRSYIEHKMQGNPNQPIKLYYNGPMFRYERK--QK 118 Query: 166 GRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVND-------RRILD 218 GRYR+F Q + G +P DAE L ++ I S + + +N + + Sbjct: 119 GRYRQFNQFGVEAIGAENP-SVDAEVLAMVMHIYQSFGLKHLKLVINSVGDMASRKEYNE 177 Query: 219 GMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVS 278 + +F + C S D + + K V A + A RI D++ + Sbjct: 178 ALVKHFEPVIHEFCSDCQSRLHTDPMRILDCK---VDRDKEAIKTAPRITDFLNEESK-- 232 Query: 279 LVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEA 338 + + YL GI + D +L RGLDYYT +E Sbjct: 233 ---------------------AYYEQVKAYLDDLGI--PYTEDPNLVRGLDYYTHTAFE- 268 Query: 339 VLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLE 398 +++ P G + ++ GGRY+GL+ + D LSI + E Sbjct: 269 LMMDNPNYDG----AITTLCGGGRYNGLLELLDGPSETGIGFALSIERLLLALEEEGIEL 324 Query: 399 ALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEA 458 +EE + + + + + +KL++ L GIKA+ Y + K+ Q++ + Sbjct: 325 DIEENL-----DLFIVTMGDQADRYAVKLLNHLRHNGIKADKDYLQR-KIKGQMKQADRL 378 Query: 459 GIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKR 500 G +IG+QEL++ I ++++T+ E + + LVE K+ Sbjct: 379 GAKFTIVIGDQELENNKIDVKNMTTGESETIELDALVEYFKK 420 >6NHI-A nrPDB Length = 457 Score = 359 bits (920), Expect = 2e-99, Method: Composition-based stats. Identities = 137/465 (29%), Positives = 258/465 (55%), Gaps = 50/465 (10%) Query: 60 KGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGED-SKLIYDLK 118 KGTRD++ ++++ R+ + + + + F+ G + ++TP FE TL GKYGE+ +LI+ + Sbjct: 15 KGTRDFTAQEVSRRKYIINTLQKNFELFGFQPLETPSFENLSTLTGKYGEEGDRLIFKIL 74 Query: 119 DQGGEL----------------------LSLRYDLTVPFARYLAMN---KLTNIKRYHIA 153 + G +LRYDLTVPFAR++AMN KRY I Sbjct: 75 NSGNYTDKVNENDWQNKDAKKLTSQISDKALRYDLTVPFARFVAMNHGQLTFPFKRYQIQ 134 Query: 154 KVYRRDNPAMTRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVND 213 V+R D P +GR+REFYQCD D+ G+ + + E +++ + L + +++N+ Sbjct: 135 PVWRADRP--QKGRFREFYQCDADVVGSE-SLWQEVELVQLYFKAFKELGV-PVAIQMNN 190 Query: 214 RRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQ 273 R+IL G+ G+++ + ++DKLDK+ + V EM EKG++ E +++ D++ Sbjct: 191 RKILSGLAEYAGITE-QLIDFTVALDKLDKIGKDGVIKEM-QEKGISNEAIEKL-DFL-F 246 Query: 274 HGGVSLVEQLLQ-DPKLSQNKQALEGLGDLKLLFEYLTLFGIDDK-ISFDLSLARGLDYY 331 H ++ +E L + + + ++G+ +L+ + GID++ + F+++LARGLDYY Sbjct: 247 HQKINALENLQELKTRFEGVEVGIQGVTELEFVLSKAMELGIDNQDLVFNITLARGLDYY 306 Query: 332 TGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFS 391 TG I+E + + +GS+ GGRY+ L +F K +P +G+S G++R + Sbjct: 307 TGAIFEV---------KAKGVEMGSIGGGGRYNNLTEVFGVK--NIPGIGISFGLDRTYL 355 Query: 392 IVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQ 451 ++E+ L + T + + L A+ ++ E +KL+++L + GI AEL Y + KL Q Sbjct: 356 VMEE--LGLFPENATVKVEYLFANYGEEEAIEAMKLIAQLREKGISAEL-YPEAAKLKKQ 412 Query: 452 LQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVE 496 Y E+ IP + +G+ E+++ + ++++T+ E+ + + + ++ Sbjct: 413 FTYAEKKEIPNLVFLGKDEIENANVTIKNLTTGEQETITQSEFLK 457 >1WU7-A nrPDB Length = 434 Score = 356 bits (912), Expect = 2e-98, Method: Composition-based stats. Identities = 116/457 (25%), Positives = 210/457 (45%), Gaps = 49/457 (10%) Query: 53 KFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDS- 111 + ++ +G RD+ P M V + +F + G ID P E + K GE+ Sbjct: 3 RLQIEKIRGFRDFYPEDMDVEKFIFKTAEEAAEAFGFRRIDFPSLEYLDLYRIKSGEELL 62 Query: 112 KLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLT--NIKRYHIAKVYRRDNPAMTRGRYR 169 + Y D+GG ++L + T R + K ++ Y KV+R + P GRYR Sbjct: 63 QQTYSFVDKGGREVTLIPEATPSTVRMVTSRKDLQRPLRWYSFPKVWRYEEPQA--GRYR 120 Query: 170 EFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGD-FLVKVNDRRILDGMFAICGVSD 228 E YQ + DI G+ P DAE + + IL L + D + +++N R+I++ + I G++ Sbjct: 121 EHYQFNADIFGSDSPE-ADAEVIALASSILDRLGLQDIYEIRINSRKIMEEI--IGGMTS 177 Query: 229 SKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPK 288 S ++ S +D+ K+S EE +++ G+ + I D G+ + ++ K Sbjct: 178 SDPFSVFSIIDRYHKISREEFVDQL-RSAGIGEDGVSMIADLCSGTRGIDEMARIT--GK 234 Query: 289 LSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAG 348 S+ + + DL L +G+ + + +D S+ RGL YYTG+++EA +A Sbjct: 235 SSEEIARMAAVEDL------LASYGVKN-VRYDFSIVRGLSYYTGIVFEAYDRSGQFRA- 286 Query: 349 EEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVE-QRLEALEEKIRTT 407 + GGRYD L + G VP VG +G I +++ + ++ EK Sbjct: 287 --------ILGGGRYDNLASLM--SGESVPAVGFGMGDAVISLLLKRENVQIPREKKSVY 336 Query: 408 ETQV------LVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIP 461 +V ++ +KL E + + E+ + G+ A QL+Y G Sbjct: 337 ICRVGKINSSIMNEYSRKLRERGMNVTVEIMERGLSA------------QLKYASAIGAD 384 Query: 462 LVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEI 498 I GE++L+ GV+ +R++ + + +V + +VE + Sbjct: 385 FAVIFGERDLERGVVTIRNMYTGSQENVGLDSVVEHL 421 >2EL9-A nrPDB Length = 431 Score = 354 bits (908), Expect = 6e-98, Method: Composition-based stats. Identities = 103/470 (21%), Positives = 190/470 (40%), Gaps = 51/470 (10%) Query: 46 GPD-ESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLM 104 GP + ++ +G DY P + A+ +++ + +G I P+ E Sbjct: 1 GPGYQDPMAKNIQAIRGMNDYLPGETAIWQRIEGTLKNVLGSYGYSEIRLPIVEQTPLFK 60 Query: 105 GKYGEDSKLI----YDLKDQGGELLSLRYDLTVPFARYLAMNKL---TNIKRYHIAKVYR 157 GE + ++ Y +D+ G+ L+LR + T R + L + ++I ++R Sbjct: 61 RAIGEVTDVVEKEMYTFEDRNGDSLTLRPEGTAGCVRAGIEHGLLYNQEQRLWYIGPMFR 120 Query: 158 RDNPAMTRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFL-VKVNDRRI 216 + P +GRYR+F+Q ++ G P I DAE + + +L I + + +++N Sbjct: 121 HERP--QKGRYRQFHQLGCEVFGLQGPDI-DAELIMLTARWWRALGISEHVTLELNS--- 174 Query: 217 LDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGG 276 + + A D+ + +KLD E+ K M Sbjct: 175 IGSLEARANYRDALVAFLEQHKEKLD----EDCKRRMYTNP------------LRVLDSK 218 Query: 277 VSLVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIY 336 V+ LL D + E L + L GI + + L RGLDYY ++ Sbjct: 219 NPEVQALLNDAPALGDYLDEESREHFAGLCKLLESAGIA--YTVNQRLVRGLDYYNRTVF 276 Query: 337 EAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQR 396 E V +Q G+V AGGRYDGLV GR P VG ++G+ER+ +V Sbjct: 277 EWVTNSLGSQ--------GTVCAGGRYDGLVEQLG--GRATPAVGFAMGLERLVLLV--- 323 Query: 397 LEALEEKIRTTET-QVLVASAQKKLLEERLKLVSELWD--AGIKAELLYKKNPKLLNQLQ 453 +A+ + + + + ++ + L L D G+K + Q Sbjct: 324 -QAVNPEFKADPVVDIYLVASGADTQSAAMALAERLRDELPGVKL-MTNHGGGNFKKQFA 381 Query: 454 YCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTG 503 ++ G + ++GE E+ +G ++ + S E+ V ++ + ++ G Sbjct: 382 RADKWGARVAVVLGESEVANGTAVVKDLRSGEQTAVAQDSVAAHLRTLLG 431 >5E3I-A nrPDB Length = 438 Score = 352 bits (902), Expect = 2e-97, Method: Composition-based stats. Identities = 111/453 (24%), Positives = 198/453 (43%), Gaps = 50/453 (11%) Query: 60 KGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLI----Y 115 KG D P Q A ++ + +G + I P+ E G+ + ++ Y Sbjct: 16 KGFNDVLPTQTAAWRRLEQHLASLMDAYGYQQIRLPIVEQTGLFKRAIGDATDIVEKEMY 75 Query: 116 DLKDQGG--ELLSLRYDLTVPFARYLAMNKLT---NIKRYHIAKVYRRDNPAMTRGRYRE 170 D+G E L+LR + T R L + L + +++ ++R + P +GRYR+ Sbjct: 76 TFFDKGNPPESLTLRPEGTAGCVRALVEHNLLRGATPRVWYMGPMFRYEKP--QKGRYRQ 133 Query: 171 FYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSD-- 228 F+Q + G P I DAE + + + + + D +V++ G +D Sbjct: 134 FHQFGVETFGVATPDI-DAELIMLTARLWKRMGV-DHMVQLE--------LNTLGETDER 183 Query: 229 SKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQD-P 287 +++R + K + +E + L RI D + +++L++ P Sbjct: 184 TEYRNALVAFLNEHKDALDEDSQRRLTTNPL------RILD-----SKIESTQKILENAP 232 Query: 288 KLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQA 347 KL + + L + L +YLT GI K + L RGLDYY ++E +Q Sbjct: 233 KLHDFLKE-DSLSHFQQLQDYLTAAGI--KFVINQKLVRGLDYYNKTVFEWTTTALGSQ- 288 Query: 348 GEEPLGVGSVAAGGRYDGLVGMFDPKG-RKVPCVGLSIGVERIFSIVEQRLEALEEKIRT 406 G+V AGGRYDGLVG K + VP VG ++G+ER+ ++EQ +A E +R Sbjct: 289 -------GTVCAGGRYDGLVGQLKGKADQSVPAVGFAMGMERLLLLLEQVEQA--EIVRD 339 Query: 407 TETQVLVAS-AQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAI 465 E ++ Q K L +L +L A + + +Q++ ++AG I Sbjct: 340 CEAFLVAEPAYQSKALVLAEQLRDQLEAANSNIRIKTGSQGSMKSQMKKADQAGAVYAII 399 Query: 466 IGEQELKDGVIKLRSVTSREEVDVRREDLVEEI 498 +GE+E + + ++ + + E+ V +LV + Sbjct: 400 LGEREWEAQQLAVKELATAEQSQVALAELVPFL 432 >4E51-A nrPDB Length = 467 Score = 342 bits (878), Expect = 2e-94, Method: Composition-based stats. Identities = 109/489 (22%), Positives = 200/489 (40%), Gaps = 77/489 (15%) Query: 41 LKAQL-GPDES---KQKF-VLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTP 95 L+AQ GP K+K L KG D P+ + E + + +G + I TP Sbjct: 12 LEAQTQGPGSMTEQKRKLEKLTGVKGMNDILPQDAGLWEFFEATVKSLLRAYGYQNIRTP 71 Query: 96 VFELKETLMGKYGEDSKLI----YDLKDQ-GGELLSLRYDLTVPFARYLAMNKLT---NI 147 + E GE + ++ Y D GE L+LR + T R + + Sbjct: 72 IVEHTPLFTRGIGEVTDIVEKEMYSFVDALNGENLTLRPENTAAVVRAAIEHNMLYDGPK 131 Query: 148 KRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDF 207 + ++I ++R + P RGRYR+F+Q + G P DAE + + + L + Sbjct: 132 RLWYIGPMFRHERP--QRGRYRQFHQVGVEALGFAGPD-ADAEIVMMCQRLWEDLGLTGI 188 Query: 208 LVKVNDRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRI 267 +++N G+++ + + +++ + + E + AD++ Sbjct: 189 KLEINS----------LGLAEER------AAHRVELIKYLE-------------QHADKL 219 Query: 268 GDYVQQHGGVSLVEQL-LQDPKLSQ----NKQALEGLGDL-KLLFEYLTLFGIDDKISFD 321 D Q+ + + L ++P L + + ++ LGD+ + FE L + + F Sbjct: 220 DDDAQRRLYTNPLRVLDTKNPALQEIVRNAPKLIDFLGDVSRAHFEGLQRLLKANNVPFT 279 Query: 322 LS--LARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPC 379 ++ L RGLDYY ++E V + AQ G+VAAGGRYD L+ G+ Sbjct: 280 INPRLVRGLDYYNLTVFEWVTDKLGAQ--------GTVAAGGRYDPLIEQLG--GKPTAA 329 Query: 380 VGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAE 439 G ++G+ERI ++++ E++ V V E+ + L D G+ Sbjct: 330 CGWAMGIERILELLKEEHLVPEQE----GVDVYVVHQGDAAREQAFIVAERLRDTGLDVI 385 Query: 440 LLYKKNP---KLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTS----RE---EVDV 489 L + +Q++ + +G I GE E+ +G ++ + E + V Sbjct: 386 LHCSADGAGASFKSQMKRADASGAAFAVIFGEDEVTNGTASVKPLRGTGDDGEKSVQQSV 445 Query: 490 RREDLVEEI 498 E L E + Sbjct: 446 PVESLTEFL 454 >1ADJ-A nrPDB Length = 421 Score = 281 bits (718), Expect = 6e-76, Method: Composition-based stats. Identities = 104/466 (22%), Positives = 197/466 (42%), Gaps = 73/466 (15%) Query: 60 KGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLI----Y 115 +GT+D +++ + +++ + + GA + TP+FE + G + ++ + Sbjct: 7 RGTKDLFGKELRMHQRIVATARKVLEAAGALELVTPIFEETQVFEKGVGAATDIVRKEMF 66 Query: 116 DLKDQGGELLSLRYDLTVPFARYLAMNKL----TNIKRYHIAKVYRRDNPAMTRGRYREF 171 +D+GG L+LR + T R + + ++ + ++R + P +GRYR+F Sbjct: 67 TFQDRGGRSLTLRPEGTAAMVRAYLEHGMKVWPQPVRLWMAGPMFRAERP--QKGRYRQF 124 Query: 172 YQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVND--------------RRIL 217 +Q +++ G+ +P++ DAE + ++ E L L + VK++ R +L Sbjct: 125 HQVNYEALGSENPIL-DAEAVVLLYECLKELGLRRLKVKLSSVGDPEDRARYNAYLREVL 183 Query: 218 DGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGV 277 DSK R + + LD S E ++ E G+ P + D +G+ + H Sbjct: 184 SPHREALS-EDSKERLEENPMRILD--SKSERDQALLKELGVRP-MLDFLGEEARAH--- 236 Query: 278 SLVEQLLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYE 337 L + ++ LE L + +L RGLDYY +E Sbjct: 237 -----------LKEVERHLERLSV---------------PYELEPALVRGLDYYVRTAFE 270 Query: 338 AVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRL 397 + AQ+ ++ GGRYDGL + G +VP VG + GVER+ +E Sbjct: 271 VHHEEIGAQS--------ALGGGGRYDGLSELLG--GPRVPGVGFAFGVERVALALEAEG 320 Query: 398 EALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEE 457 L E+ + + ++ + E L L ++AE K L+ + Sbjct: 321 FGLPEEKGP---DLYLIPLTEEAVAEAFYLAEALRPR-LRAEYALAPR-KPAKGLEEALK 375 Query: 458 AGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTG 503 G +GE EL+ G + L+ + + E+V + RE++ + + G Sbjct: 376 RGAAFAGFLGEDELRAGEVTLKRLATGEQVRLSREEVPGYLLQALG 421 >3OD1-A nrPDB Length = 400 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 82/396 (20%), Positives = 158/396 (39%), Gaps = 33/396 (8%) Query: 48 DESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKY 107 + + F+ + P G RD P ++ + D + G ++I+TP E ET+ Sbjct: 2 NAMSKPFMFEKPFGMRDTLPEWYKTKKNICDQMTEEINLWGYDMIETPTLEYYETVGVVS 61 Query: 108 GEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAM---NKLTNIKRYHIAKVYRRDNPAMT 164 + ++ L DQ G L LR D+T P AR +A ++ ++ + + VYR Sbjct: 62 AILDQQLFKLLDQQGNTLVLRPDMTAPIARLVASSLKDRAYPLRLAYQSNVYRAQQN--E 119 Query: 165 RGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAIC 224 G+ EF Q ++ G+ D E + +M L + +F V + ++ + Sbjct: 120 GGKPAEFEQLGVELIGD-GTASADGEVIALMIAALKRAGLSEFKVAIGHVGYVNALLMDV 178 Query: 225 GVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLL 284 ++ + + + + + V + E V L+ R+ + + GG + +E+ Sbjct: 179 VGNEQRADRLRRFLYEKNYVGYRE----HVKSLNLSTIDKSRLMNLLSLRGGRAAIEEA- 233 Query: 285 QDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTP 344 L Q ++ L ++ L+E L +G + + FDL+L + YYTGV++E + Sbjct: 234 --RGLIQTEKGKTALAEMTKLYEVLESYGASEYVKFDLTLVLHMSYYTGVVFEGYGNRLG 291 Query: 345 AQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKI 404 + +GGRYD L+ F R G + ++ + + E I Sbjct: 292 V----------PLCSGGRYDELLSKFH---RPAQATGFGVRIDLLVEALNG------EII 332 Query: 405 RTTETQVLVASAQKKLLEERLKLVSELWDAGIKAEL 440 Q + + E ++L + G L Sbjct: 333 SNGHEQTCIL-FSNERRFEAIELARKKRANGEAVVL 367 >3RAC-A nrPDB Length = 373 Score = 271 bits (692), Expect = 6e-73, Method: Composition-based stats. Identities = 96/375 (25%), Positives = 169/375 (45%), Gaps = 40/375 (10%) Query: 49 ESKQKFVLKTP---KGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMG 105 E+ + F + P G D++ R+ AV ++ + + G E + + +FE +TL+ Sbjct: 17 EAVRGFADRPPGMQDGYPDFAKRRRAVETRLLSFV----EDAGYEPVTSGLFEYVDTLLR 72 Query: 106 -KYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLA---MNKLTNIKRYHIAKVYRR-DN 160 + E S+ L D GG+ ++LR ++T AR A T I+ + +VYRR D+ Sbjct: 73 ARSPESSRDWIRLFDGGGDAVALRPEMTPSIARMAAPRVAAGRTPIRWCYCERVYRRTDD 132 Query: 161 PA---MTRGRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRIL 217 PA G+ E Q + G + D + L+++ E ++ + + V+ R++ Sbjct: 133 PASLSWASGKAAESTQVGIERIGEEASVDVDMDVLRLLHEASAAAGVRHHRIVVSHARLV 192 Query: 218 DGMFAICGVSDSKFRTICSSVDKLDKVSWEEV------KNEMVGEKGLAPEVADRIGDYV 271 + G+S S R + + + V + E+ K+ + L A+R Sbjct: 193 PRLLDALGISASLSRAFLACLTSGNYVQFRELWQLHAAKDVDLLANLLTWSPAERDAAKR 252 Query: 272 QQHGGVSLVEQLLQ---DPKLSQNKQALEGLGDLKLLFEYLTLFGI-DDKISFDLSLARG 327 + +E LL+ DP+ + + + + L L E L G+ D ++FDL+L R Sbjct: 253 SREASDRELEALLRDAVDPRAAADVR--DAWRYLCRLAEALHDSGLASDVVTFDLALHRE 310 Query: 328 LDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVE 387 LDYYTG+++E A +A GGRYD L+ F G P VG + VE Sbjct: 311 LDYYTGLVFEMFAPGVGA----------PIAQGGRYDELLAQF---GAGAPAVGFAFEVE 357 Query: 388 RIFSIVEQRLEALEE 402 R+ +++E + E E Sbjct: 358 RVMAVLEAQEEGEGE 372 >1Z7M-A nrPDB Length = 344 Score = 188 bits (477), Expect = 5e-48, Method: Composition-based stats. Identities = 71/361 (19%), Positives = 147/361 (40%), Gaps = 43/361 (11%) Query: 52 QKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLM-----GK 106 +K P+ + + + Q+ ++ + + F + + P FE + GK Sbjct: 18 EKINYLLPEESAEMTLNQVKSLRQIEGRLRKLFSLKNYQEVMPPSFEYTQLYTALESNGK 77 Query: 107 YGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRY-HIAKVYRRDNPAMTR 165 K+ +K +G + ++LRYD T+P R + K + RY + K++R++ + Sbjct: 78 TFNQEKMFQFIKHEG-QSITLRYDFTLPLVRLYSQIKDSTSARYSYFGKIFRKEKRH--K 134 Query: 166 GRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICG 225 GR E YQ ++ G + E L + +++ L + + ++ + + C Sbjct: 135 GRSTENYQIGIELFG-ESADKSELEILSLALQVIEQLGLNKTVFEIGSAKFFQRL---CQ 190 Query: 226 VSDSKFRTICSSVDKLDKVSWEEV--KNEMVGE-KGLAPEVADRIGDYVQQHGGVSLVEQ 282 ++D + + K D KN E +GL E+ ++ +S +E Sbjct: 191 LADGSTELLTELLLKKDLSGLNAFIEKNNFSKELRGLLKEI------FITNE--LSRLEN 242 Query: 283 LLQDPKLSQNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQ 342 L+ + K + + LK E L++ I DL + +DYYT ++++A Sbjct: 243 LVTNTK---DDVLISSFDQLKEFSEKLSMI---KPIIIDLGMVPKMDYYTDLMFKAY--- 293 Query: 343 TPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEE 402 + A +P + +GGRYD L+ F + +G ++ I +E++ + Sbjct: 294 --SSAANQP-----ILSGGRYDQLLSNFQ---EEAFAIGFCCHMDTILKALERQELEEDN 343 Query: 403 K 403 Sbjct: 344 D 344 >2LW7-A nrPDB Length = 170 Score = 119 bits (297), Expect = 4e-27, Method: Composition-based stats. Identities = 108/112 (96%), Positives = 109/112 (97%) Query: 398 EALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEE 457 +ALEEKIRTTETQVLVASAQKKLLEERLKLVSEL DAGIKAELLYKKNPKLLNQLQYCEE Sbjct: 59 KALEEKIRTTETQVLVASAQKKLLEERLKLVSELQDAGIKAELLYKKNPKLLNQLQYCEE 118 Query: 458 AGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQPLCIC 509 AGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQPL I Sbjct: 119 AGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEIKRRTGQPLSIS 170 Score = 94.9 bits (234), Expect = 7e-20, Method: Composition-based stats. Identities = 59/63 (93%), Positives = 60/63 (95%) Query: 2 AERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPKG 61 AERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPK Sbjct: 1 AERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPKA 60 Query: 62 TRD 64 + Sbjct: 61 LEE 63 >6FUA-A nrPDB Length = 388 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 74/388 (19%), Positives = 144/388 (37%), Gaps = 36/388 (9%) Query: 59 PKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKE-TLMGKYGEDSKLIYDL 117 P G D +E + + + HG +++ P+ E E L G + + + + Sbjct: 4 PDGVADVLFEDAHKQEVLRHQLTQQLITHGYQLVSPPMIEFTESLLSGASEDLKRQTFKI 63 Query: 118 KDQ-GGELLSLRYDLTVPFARYLAMNKLTNIKRY-HIAKVYRRDNPAMTRGRYREFYQCD 175 DQ G L+ +R D+T R A + I RY + V P+ G R Q Sbjct: 64 IDQLTGRLMGIRADITPQILRIDAHHGGDGIARYCYAGDVI-HTLPSGLFG-SRTPLQLG 121 Query: 176 FDIAGNFDPMIPDAECLKIMCEILSSLQIGDFL-VKVNDRRILDGMFAICGVSDSKFRTI 234 +I G + D E + ++ +++SL + L V + I + + +S S + Sbjct: 122 AEIFGCE-SIAADIELIDVLFSMINSLDMSAVLHVDLGHVTIFKRLAELAALSASDTEQL 180 Query: 235 CSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQ--DPKLSQN 292 + + E +V D+ + LL Q+ Sbjct: 181 MQLYANKN-----------LPELKQVCQVLPMGSDFYTLARFGHDIANLLGRLSENAQQD 229 Query: 293 KQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPL 352 + + + +L+ L +L +S D++ G Y+TG+++ + Sbjct: 230 TKIVTAIDELQRLKAHLQ-VQWQCAVSIDVTELSGYHYHTGIVFNGYINS---------- 278 Query: 353 GVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQVL 412 + GGR+DG+ + G S+ V R+ + +L+A + + Sbjct: 279 ETQPLVRGGRFDGMKSNQLATNQPRQATGFSMDVSRLLA--HTQLDAPFIVLIDYDAFNN 336 Query: 413 VASAQKKLLEERLKLVSELWDAGIKAEL 440 + SAQ++LL L+ V+ L G + + Sbjct: 337 LDSAQRQLL---LQQVASLRQQGYRVTM 361 >1X59-A nrPDB Length = 73 Score = 98.3 bits (243), Expect = 7e-21, Method: Composition-based stats. Identities = 60/60 (100%), Positives = 60/60 (100%) Query: 1 MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPK 60 MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPK Sbjct: 8 MAERAALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPK 67 >2I4O-A nrPDB Length = 458 Score = 67.5 bits (163), Expect = 1e-11, Method: Composition-based stats. Identities = 71/492 (14%), Positives = 139/492 (28%), Gaps = 79/492 (16%) Query: 21 LKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPKGTRDYSPRQMAVREKVFDVI 80 LK+ AE++ L L+A + + G + P V +K+ ++ Sbjct: 31 LKENPKEAEIVSHR----LMLRA---------GMLRQEAAGIYAWLPLGHRVLKKIEQIV 77 Query: 81 IRCFKRHGAEVIDTPVFELKETLM--GKYGEDSKLIYDLKDQGGELLSLRY---DLTVPF 135 R GA + P +L + G+Y + + D+ L ++ Sbjct: 78 REEQNRAGAIELLMPTLQLADLWRESGRYDAYGPEMLRIADRHKRELLYGPTNEEMITEI 137 Query: 136 ARYLAMN-KLTNIKRYHIAKVYRRD-NPAMTRGRYREF-----YQCDFDIAGNFDPMIPD 188 R + K + YHI +R + P R REF Y D D AG Sbjct: 138 FRAYIKSYKSLPLNLYHIQWKFRDEQRPRFGVMRGREFLMKDAYSFDVDEAGARKSYN-- 195 Query: 189 AECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEE 248 + + + + + + + + + + Sbjct: 196 -KMFVAYLRTFARMGL----------KAIPMRAETGPIGGDLSHEFIVLAETGESGVY-- 242 Query: 249 VKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLGDLKLLFEY 308 + V + E D GD + V +D + + + + + L Sbjct: 243 -IDRDVLNLPVPDENVDYDGDLTPIIKQWTSVYAATED--VHEPARYESEVPEANRLNTR 299 Query: 309 LTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVG 368 G +Y G A + GG Y Sbjct: 300 GIEVGQI--------------FYFGT---KYSDSMKANVTGPDGTDAPI-HGGSY----- 336 Query: 369 MFDPKGRKVPCVGLSIGVERIFSIVEQRLEAL-EEKIRTTETQVLVASAQKKLLEERL-K 426 VG+S + I + E + +L + + Sbjct: 337 ----------GVGVSRLLGAIIEACHDDNGIIWPEAVAPFRVTILNLKQGDAATDAACDQ 386 Query: 427 LVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREE 486 L EL G+ L + + + + GIP +G + L +G ++L+ + Sbjct: 387 LYRELSAKGVDV-LYDDTDQRAGAKFATADLIGIPWQIHVGPRGLAEGKVELKRRSDGAR 445 Query: 487 VDVRREDLVEEI 498 ++ D+V + Sbjct: 446 ENLALADVVARL 457 >1NYR-A nrPDB Length = 645 Score = 65.6 bits (158), Expect = 4e-11, Method: Composition-based stats. Identities = 63/445 (14%), Positives = 144/445 (32%), Gaps = 84/445 (18%) Query: 61 GTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKY---GEDSKLIYDL 117 G + P +R ++ I+ G + + TPV + + + Sbjct: 262 GLPLWLPNGATIRREIERYIVDKEVSMGYDHVYTPVLANVDLYKTSGHWDHYQEDMFPPM 321 Query: 118 KDQGGELLSLRYDLTVPFARYLA----MNKLTNIKRYHIAKVYRRDNPAMTRG--RYREF 171 + E + LR A + I+ + ++R + G R R Sbjct: 322 QLDETESMVLRPMNCPHHMMIYANKPHSYRELPIRIAELGTMHRYEASGAVSGLQRVRGM 381 Query: 172 YQCDFDIAGNFDPMIPDAE-CLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSK 230 D I D + + + + ++ ++ D+ +++ R Sbjct: 382 TLNDSHIFVRPDQIKEEFKRVVNMIIDVYKDFGFEDYSFRLSYR---------------- 425 Query: 231 FRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLS 290 D DK + + + + + E AD +G + + E PKL Sbjct: 426 --------DPEDKEKYFDDDDMWNKAENMLKEAADELG--LSYEEAIG--EAAFYGPKL- 472 Query: 291 QNKQALEGLGDLKLLFEYLTLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEE 350 + Q +G + L F + ++ FDL+ Y G Q GE Sbjct: 473 -DVQVKTAMGKEETLSTAQLDFLLPER--FDLT-------YIG------------QDGEH 510 Query: 351 PLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIGVERIFSIVEQRLEALEEKIRTTETQ 410 V V G+ +ER + + + + + Sbjct: 511 HRPV----------------------VIHRGVVSTMERFVAFLTEETKGAFPTWLAPKQV 548 Query: 411 VLVASAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQE 470 ++ + +L EL G++ + +N K+ +++ + IP ++G++E Sbjct: 549 QIIPVNVDLHYDYARQLQDELKSQGVRVSID-DRNEKMGYKIREAQMQKIPYQIVVGDKE 607 Query: 471 LKDGVIKLRSVTSREEVDVRREDLV 495 +++ + +R S+++ V +++ + Sbjct: 608 VENNQVNVRQYGSQDQETVEKDEFI 632 >1USY-C nrPDB Length = 275 Score = 54.4 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 57/294 (19%), Positives = 98/294 (33%), Gaps = 48/294 (16%) Query: 74 EKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTV 133 EKVF + K+ G P E E G D+ G L S+R D T Sbjct: 7 EKVFSFYSKATKK-GFSPFFVPALEKAEEPAGN---------FFLDRKGNLFSIREDFTK 56 Query: 134 PFARYLAMNKLT----NIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAGNFDPMIPDA 189 L K IK ++ VYR + YQ + + + Sbjct: 57 TV---LNHRKRYSPESQIKVWYADFVYRYSGSDLVA-----EYQLGLEKV-PRNSLDDSL 107 Query: 190 ECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEV 249 E L+I+ E S G +V++ + + + + + + +D + E Sbjct: 108 EVLEIIVESASEFFEGPVIVEIGHTGLYEDLLK--EIPKDLHEKVLNLIDTKNLAEIE-- 163 Query: 250 KNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLGDLKLLFEYL 309 + K + ++I + ++ + D LS + L L+ F + Sbjct: 164 --FLSHMKKIDLSRVEKIIEDSIYRRSPEHLKTM--DLPLSVREDLLSASSFLQEKFPTV 219 Query: 310 TLFGIDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRY 363 + + DL+LAR ++ Y G+I+ VAAGG Y Sbjct: 220 S-------VEIDLTLARTIEEYCGLIFTIYDTS----------SSRLVAAGGEY 256 >1NJ8-A nrPDB Length = 459 Score = 47.1 bits (110), Expect = 2e-05, Method: Composition-based stats. Identities = 31/164 (18%), Positives = 56/164 (34%), Gaps = 23/164 (14%) Query: 60 KGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKD 119 KG Y P +R F++I G + P+ ++ L +++ I +D Sbjct: 28 KGCGVYLPYGFKIRRYTFEIIRNLLDESGHDEALFPMLIPEDLLAK----EAEHIKGFED 83 Query: 120 Q------GGEL-----LSLRYDLTVPFARY----LAMNKLTNIKRYHIAKVYRRDNPAMT 164 + GG+ L+LR P + ++ IK Y I +R + Sbjct: 84 EVYWVTHGGKTQLDVKLALRPTSETPIYYMMKLWVKVHTDLPIKIYQIVNTFRYETKHTR 143 Query: 165 RG-RYRE---FYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQI 204 R RE F + + + E + I + +L I Sbjct: 144 PLIRLREIMTFKEAHTAHSTKEEAENQVKEAISIYKKFFDTLGI 187 >6JP2-A nrPDB Length = 278 Score = 46.7 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 37/237 (15%), Positives = 79/237 (33%), Gaps = 23/237 (9%) Query: 14 QGERVR----GLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPKGTRDYSPRQ 69 Q +R+R G +QK +L + A ++ +E K K ++ P Sbjct: 12 QIQRLREYGNGTYEQKVFEDLASRDAAFSKEMSVASTDNEKKIKGMIANPS--------- 62 Query: 70 MAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRY 129 ++ + I G + TP+F K+ L + K ++ E +LR Sbjct: 63 RHGLTQLMNDIADALVAEGFIEVRTPIFISKDALARMTITEDKPLFKQVFWIDEKRALRP 122 Query: 130 DLTV---PFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAGNFDPMI 186 L R L + +K + + +R+++ + EF + G Sbjct: 123 MLAPNLYSVMRDLRDHTDGPVKIFEMGSCFRKESHSGMH--LEEFTMLNLVDMGPRGDAT 180 Query: 187 PDAECLKIMCE-ILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDKLD 242 E LK ++ + + D+ + + + ++ + + LD Sbjct: 181 ---EVLKNYISVVMKAAGLPDYDLVQEESDVYKETID-VEINGQEVCSAAVGPHYLD 233 >3A31-A nrPDB Length = 471 Score = 46.7 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 61/360 (16%), Positives = 114/360 (31%), Gaps = 38/360 (10%) Query: 40 KLKAQLGPDESK----QKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTP 95 +L + PD ++F T G +S +R + +V+ + R G V++TP Sbjct: 15 ELDITVKPDSRVPVFNREFATFTGAGVPLFSLGGGPIRYALAEVLAKFHARRGYYVVETP 74 Query: 96 VFELKETLMGKYGED--SKLIYDLKDQGGELLSLRYDLTVP----FARYLAMNKL---TN 146 + E + +Y L D G +++ F +A ++ Sbjct: 75 IIASTELFKVSGHIEFYRNNMY-LFDIEGHEFAVKPMNCPYHILLFLNEVAKHRSKLPLP 133 Query: 147 IKRYHIAKVYRRDNPAMTRG--RYREFYQCDFDIA---GNFDPMIPDA-ECLKIMCEILS 200 K + +V+R + G R R F Q D I G ++ D E +K++ E L Sbjct: 134 FKVFEFGRVHRYEPSGSIYGLLRVRGFTQDDAHIIVPGGRVIDVVYDVFEEMKLVLERLF 193 Query: 201 SLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLA 260 L + KV +SD K + EE E Sbjct: 194 KLGVSSETFKV-----------RLSMSDKSLIGKEFMGSKEEWEGAEEALREAASRINEK 242 Query: 261 --PEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGL-----GDLKLLFEYLTLFG 313 ++ + G+ + + + + + + +L FG Sbjct: 243 YGIDIVELEGEAAFYGPKLDFIMMVEESGVSKEWQMGTIQFDFNLPRRFRLYDVVREEFG 302 Query: 314 IDDKISFDLSLARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPK 373 I++ +L ++ + GV E + P V +V GG D + Sbjct: 303 IEEVYIIHRALLGSIERFLGVYLEHRRGRMPFTLAPIQFAVIAVKTGGEVDREIEDLASS 362 >6NAB-A nrPDB Length = 513 Score = 44.0 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 24/161 (14%), Positives = 49/161 (30%), Gaps = 22/161 (13%) Query: 60 KGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDL-- 117 G + P V E V K+ G + + P+F + + Sbjct: 42 SGCYIFRPNCWFVWESVQKFFDAEIKKLGVQNVMFPLF----VTKRALETEKDHVEGFSP 97 Query: 118 ----KDQGGEL-----LSLRYD----LTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMT 164 + G ++LR + +A+++ ++ +K V R + Sbjct: 98 EVAWVTKSGNSDLQEPIALRPTSETIMYPSYAKWIQSHRDLPLKLNQWTNVVRWEFKHAV 157 Query: 165 RG-RYREFY-QCDFDIAGNFDPMIPDA-ECLKIMCEILSSL 202 R REFY Q + + + L++ + L Sbjct: 158 PFIRSREFYWQEGHSAFKSKEEADEEVFTILELYKRVYEEL 198 Score = 40.6 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 26/120 (21%), Positives = 49/120 (40%), Gaps = 6/120 (5%) Query: 381 GLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASA------QKKLLEERLKLVSELWDA 434 GLS + +V + + R QV+V L+E+ ++ +EL A Sbjct: 270 GLSTRTLGVMIMVHGDDKGMVLPPRVAFCQVVVIPLIFKDKDNATLVEKTKEIYNELEKA 329 Query: 435 GIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDL 494 GI+ +L + + Y E G+PL +G ++L+ I L + E+ + + Sbjct: 330 GIRVKLDDRLERTPGWKYNYWELRGVPLRIEVGPKDLEKQQIMLCRRDTGEKWTMPLSEF 389 >5Z5E-A nrPDB Length = 534 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 27/136 (19%), Positives = 57/136 (41%), Gaps = 19/136 (13%) Query: 382 LSIGVER-----IFSIVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSELWDAGI 436 LS GV+R I + + +E + + + +V K L ++ + L + Sbjct: 394 LSFGVDRNVLALIDLFLTEEEYEIERDNQKVKEKRVVLKIPKHLAPIKVAVFPLLKKPEL 453 Query: 437 --KAE------------LLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVT 482 KA+ ++Y + + + + +E G+P I Q L+D + +R Sbjct: 454 IEKAKEVYNMLKNYFYPIIYDEQGSIGRRYRRVDEIGVPYAITIDYQTLEDNTVTIRDRD 513 Query: 483 SREEVDVRREDLVEEI 498 + ++V V+ EDL ++ Sbjct: 514 TMKQVRVKIEDLPNQL 529 >4K87-A nrPDB Length = 535 Score = 43.3 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 27/157 (17%), Positives = 54/157 (34%), Gaps = 14/157 (8%) Query: 60 KGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGK-------YGEDSK 112 G P A+ E + D K+ G E P+F + L + E + Sbjct: 67 SGCYILRPWAYAIWEAIKDFFDAEIKKLGVENCYFPMFVSQSALEKEKTHVADFAPEVAW 126 Query: 113 LIYDLKDQGGELLSLRYD----LTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRG-R 167 + K + E +++R + +A+++ ++ IK V R + R Sbjct: 127 VTRSGKTELAEPIAIRPTSETVMYPAYAKWVQSHRDLPIKLNQWCNVVRWEFKHPQPFLR 186 Query: 168 YREF-YQCDFDIAGNFDPMIPDA-ECLKIMCEILSSL 202 REF +Q + + + L + ++ L Sbjct: 187 TREFLWQEGHSAFATMEEAAEEVLQILDLYAQVYEEL 223 >6MN8-A nrPDB Length = 505 Score = 41.7 bits (96), Expect = 8e-04, Method: Composition-based stats. Identities = 19/88 (21%), Positives = 41/88 (46%) Query: 415 SAQKKLLEERLKLVSELWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDG 474 + L+E+ ++ ++L DA I+AEL + + + + E G+P+ IG ++L + Sbjct: 310 EQKTALIEKAKEINNKLMDASIRAELDIRDHISPGWKFNHWELKGVPVRIEIGPKDLANN 369 Query: 475 VIKLRSVTSREEVDVRREDLVEEIKRRT 502 + S E+ + + L + K Sbjct: 370 QVTCVIRYSGEKRTIPIDGLASKCKDML 397 Score = 38.6 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 27/157 (17%), Positives = 54/157 (34%), Gaps = 14/157 (8%) Query: 60 KGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLI--YDL 117 G P A+ E + + K+ G + P+F + L + S Sbjct: 37 SGCYVLRPWSYAIWEFIQEWFDEEIKKLGVKNCYFPLFVSQSALEKEKTHISDFAPEVAW 96 Query: 118 KDQGGEL-----LSLRYD----LTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRG-R 167 + G+ +++R + +A+++ ++ IK V R + T R Sbjct: 97 ITRAGQSDLAEAIAIRPTSETVMYPSYAKWVQSHRDLPIKLNQWCNVVRWEFKHPTPFLR 156 Query: 168 YREF-YQCDFDIAGNFDPMIPDA-ECLKIMCEILSSL 202 REF +Q + D + + L + +I L Sbjct: 157 TREFLWQEGHTAFQSKDEAEDEVFKILDLYAQIYIDL 193 >1B76-A nrPDB Length = 442 Score = 41.0 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 20/130 (15%), Positives = 54/130 (41%), Gaps = 11/130 (8%) Query: 383 SIGVERIFSIVEQRLEALEEKIRTTETQVL-VASAQKKLLEERLKLVSELWDAGIKAELL 441 + E + + E+ + L+ ++ + V+ + + ++ E +L + L G+ +L Sbjct: 312 AFTREELPNGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEYAKRLKARLLALGLG-RVL 370 Query: 442 YKKNPKLLNQLQYCEEAGIPLVAIIGEQEL---KDGV------IKLRSVTSREEVDVRRE 492 Y+ + + +E G P + + KDG + +R + E++ + + Sbjct: 371 YEDTGNIGKAYRRHDEVGTPFAVTVDYDTIGQSKDGTTRLKDTVTVRDRDTMEQIRLHVD 430 Query: 493 DLVEEIKRRT 502 +L ++ R Sbjct: 431 ELEGFLRERL 440 >1NJ2-A nrPDB Length = 501 Score = 41.0 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 25/129 (19%), Positives = 50/129 (38%), Gaps = 6/129 (4%) Query: 379 CVGLSIGVERIFSIVEQRLEAL--EEKIR---TTETQVLVASAQKKLLEERLKLVSELWD 433 C GLS V + L + ++ A ++++E +L S L Sbjct: 285 CYGLSDRVIASVIAIHGDESGLCLPPDVAAHQVVIVPIIFKKAAEEVMEACRELRSRLEA 344 Query: 434 AGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRRED 493 AG + L ++ + + E G+PL IG ++L+ G + + E+V + Sbjct: 345 AGFRVHLD-DRDIRAGRKYYEWEMRGVPLRVEIGPRDLEKGAAVISRRDTGEKVTADLQG 403 Query: 494 LVEEIKRRT 502 + E ++ Sbjct: 404 IEETLRELM 412 >5W25-A nrPDB Length = 616 Score = 40.6 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 39/242 (16%), Positives = 69/242 (28%), Gaps = 42/242 (17%) Query: 63 RDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIY---DLKD 119 RD + +R +V RH I+TP T+ E ++ L Sbjct: 155 RDDPAAAIRLRSRVNAAARAVLARHDFVEIETP------TITRSTPEGARDFLVPARLHP 208 Query: 120 QGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIA 179 L L M + I R + + +R D EF Q D ++ Sbjct: 209 GSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQP-------EFTQLDMEM- 260 Query: 180 GNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVD 239 DAE + + +L ++A+ G + Sbjct: 261 -----SFVDAEDIIAI-----------------SEEVLTELWALIGYRIPTPIPRIGYAE 298 Query: 240 KLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGL 299 + + ++ E E D D + V ++ SQ ++ L+G Sbjct: 299 AMRRFGTDKPDLRFGLEL---VECTDFFSDTTFRVFQAPYVGAVVMPGGASQPRRTLDGW 355 Query: 300 GD 301 D Sbjct: 356 QD 357 >1ATI-A nrPDB Length = 505 Score = 40.6 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 20/130 (15%), Positives = 54/130 (41%), Gaps = 11/130 (8%) Query: 383 SIGVERIFSIVEQRLEALEEKIRTTETQVL-VASAQKKLLEERLKLVSELWDAGIKAELL 441 + E + + E+ + L+ ++ + V+ + + ++ E +L + L G+ +L Sbjct: 375 AFTREELPNGEERIVLKLKPQLAPIKVAVIPLVKNRPEITEYAKRLKARLLALGLG-RVL 433 Query: 442 YKKNPKLLNQLQYCEEAGIPLVAIIGEQEL---KDGV------IKLRSVTSREEVDVRRE 492 Y+ + + +E G P + + KDG + +R + E++ + + Sbjct: 434 YEDTGNIGKAYRRHDEVGTPFAVTVDYDTIGQSKDGTTRLKDTVTVRDRDTMEQIRLHVD 493 Query: 493 DLVEEIKRRT 502 +L ++ R Sbjct: 494 ELEGFLRERL 503 >4P3N-A nrPDB Length = 415 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 36/236 (15%), Positives = 83/236 (35%), Gaps = 14/236 (5%) Query: 44 QLGPDESKQKFVLKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETL 103 ++G D+ F +P + P+ + + + I +++ G + + TP Sbjct: 17 KIGRDQELYFFHELSPGSCF-FLPKGAYIYNALIEFIRSEYRKRGFQEVVTPNIFNSRLW 75 Query: 104 M--GKYGEDSKLIYDLKDQGGELLSLRYDLTVPFARYLAMN----KLTNIKRYHIAKVYR 157 M G + S+ ++ + + EL +L+ + ++ ++R Sbjct: 76 MTSGHWQHYSENMFSFEVE-KELFALKPMNCPGHCLMFDHRPRSWRELPLRLADFGVLHR 134 Query: 158 RDNPAMTRG--RYREFYQCDFDIAGNFDPMIPDAE-CLKIMCEILSSLQIGDFLVKVNDR 214 + G R R F Q D I + + + + CL + + S F K+N Sbjct: 135 NELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRTVYSVFG---FSFKLNLS 191 Query: 215 RILDGMFAICGVSDSKFRTICSSVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDY 270 + V D + + +S+++ + + + ++ D IG Y Sbjct: 192 TRPEKFLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFYGPKIDIQIKDAIGRY 247 >3WRZ-A nrPDB Length = 367 Score = 39.8 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 51/304 (16%), Positives = 92/304 (30%), Gaps = 47/304 (15%) Query: 25 KASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPKGT-----------------RDYSP 67 + + E+++ VA L+ +AQ P L P+GT D Sbjct: 7 RQTREVLDPIVASLM--EAQQIPG---MAIALVRPEGTTISHYGAADRETGTPVDDDTLF 61 Query: 68 RQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSL 127 ++ + + + + G D PV L G +D + GG L Sbjct: 62 EIGSLSKTLTATLASLAEVEGKLDFDAPVSRYLPELEGSAFDDISGLNLGTHTGGGLPLF 121 Query: 128 RYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAGNFDPMIP 187 D ++ + + Y R P G R + + G Sbjct: 122 VPDE--------VTDRASLMAWY------REWQPTEPIGESRTYSNLGIGLLGLETAASL 167 Query: 188 DAE-CLKIMCEILSSLQIGDFLVKVNDRRIL----------DGMFAICGVSDSKFRTICS 236 D E + ++L+ L + D V + R+ GV D + I + Sbjct: 168 DGEFVPTMRAKVLAPLGMQDTWYDVPEARMADYAMGEDKDGQPTRVSPGVLDDEAYGIKT 227 Query: 237 SVDKLDKVSWEEVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQAL 296 + L K+ + V + A R G Y +L+ + P + +A Sbjct: 228 TAADLAKLVRANLHLADVDAELQQAIDATRQGHYRVGDMTQALIWEQYSLPVAPETLRAG 287 Query: 297 EGLG 300 +G Sbjct: 288 QGYD 291 >3VQX-A nrPDB Length = 291 Score = 39.0 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 24/137 (17%), Positives = 46/137 (33%), Gaps = 6/137 (4%) Query: 49 ESKQKFVLKTPKGTRDYSPRQMAVRE-KVFDVIIRCFKRHGAEVIDTPVFELKETLMGKY 107 E + + + + K + + K+ I R F G I +P+ E + Sbjct: 55 ELESELLSRRKKDLQQIYAEERENYLGKLEREITRFFVDRGFLEIKSPILIPLEYIERMG 114 Query: 108 GEDSKLIYDLKDQGGELLSLRYDLTVPF---ARYLAMNKLTNIKRYHIAKVYRRDNPAMT 164 ++ + + + LR L R L IK + I YR++ + Sbjct: 115 IDNDTELSKQIFRVDKNFCLRPMLAPNLYNYLRKLDRALPDPIKIFEIGPCYRKE--SDG 172 Query: 165 RGRYREFYQCDFDIAGN 181 + EF +F G+ Sbjct: 173 KEHLEEFTMLNFCQMGS 189 >1IL2-A nrPDB Length = 590 Score = 37.9 bits (86), Expect = 0.010, Method: Composition-based stats. Identities = 30/147 (20%), Positives = 57/147 (38%), Gaps = 14/147 (9%) Query: 66 SPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELL 125 +++ R K+ ++ R HG I+TP+ T G L+ +G + Sbjct: 134 MAQRLKTRAKITSLVRRFMDDHGFLDIETPML----TKATPEGARDYLVPSRVHKG-KFY 188 Query: 126 SLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAGNFDPM 185 +L F + L M+ + Y I K +R ++ R EF Q D + + P Sbjct: 189 AL-PQSPQLFKQLLMMSGFD--RYYQIVKCFRDEDLRAD--RQPEFTQIDVETSFMTAPQ 243 Query: 186 IPDAECLKIMCEIL---SSLQIGDFLV 209 + + ++ + + +GDF V Sbjct: 244 VREV-MEALVRHLWLEVKGVDLGDFPV 269 >5XIL-A nrPDB Length = 512 Score = 37.9 bits (86), Expect = 0.012, Method: Composition-based stats. Identities = 27/123 (21%), Positives = 49/123 (39%), Gaps = 10/123 (8%) Query: 381 GLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASAQ------KKLLEERL----KLVSE 430 GLS V + +V + R TQV++ ++ +E L +L SE Sbjct: 263 GLSTRVIGVMIMVHGDNRGMVMPPRVASTQVIIIPVGITKDTTEEARQELLASCWRLESE 322 Query: 431 LWDAGIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVR 490 L + G++A + N + + E G+PL +G +EL + + + S V Sbjct: 323 LCEGGVRARCDLRDNYSPGWRFNHWEVKGVPLRVELGPRELAERSLAVAVRHSGARHSVA 382 Query: 491 RED 493 + Sbjct: 383 WDA 385 >4WJ3-M nrPDB Length = 599 Score = 36.7 bits (83), Expect = 0.022, Method: Composition-based stats. Identities = 46/249 (18%), Positives = 89/249 (35%), Gaps = 25/249 (10%) Query: 11 VKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESKQKFVLKTPKGTR--DYSPR 68 V+L+ E R S E++ E+ L + + P + +T R D Sbjct: 84 VRLRPEGARNPNMASGSIEVLGYELEVLNQAETPPFPLDEYSDVGEETRLRYRFIDLRRP 143 Query: 69 QMA----VREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKL-IYDLKDQGGE 123 +MA +R ++ I R +G ++TP+ L E ++ + + G Sbjct: 144 EMAAKLKLRARITSSIRRYLDDNGFLDVETPI------LGRPTPEGARDYLVPSRTYPGH 197 Query: 124 LLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAGNFD 183 +L + + L M + + Y IAK +R ++ R EF Q D + Sbjct: 198 FFAL--PQSPQLFKQLLMVAGFD-RYYQIAKCFRDEDLRAD--RQPEFTQIDIE-----T 247 Query: 184 PMIPDAECLKIMCEILSSL--QIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDKL 241 + +++ + I +++ L ++ D + G R VD Sbjct: 248 SFLDESDIIGITEKMVRQLFKEVLDVEFDEFPHMPFEEAMRRYGSDKPDLRIPLELVDVA 307 Query: 242 DKVSWEEVK 250 D++ E K Sbjct: 308 DQLKEVEFK 316 >4RMF-A nrPDB Length = 609 Score = 36.7 bits (83), Expect = 0.025, Method: Composition-based stats. Identities = 25/143 (17%), Positives = 45/143 (31%), Gaps = 21/143 (14%) Query: 63 RDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIY---DLKD 119 R+ + +R KV H I+TP TL E ++ L+ Sbjct: 130 REGPGNALRLRSKVNAAARSVLAEHDFVEIETP------TLTRSTPEGARDFLVPARLQP 183 Query: 120 QGGELLSLRYDLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIA 179 L L M + I R + + +R D EF Q D ++ Sbjct: 184 GSFYALPQSPQLFKQLLMVAGMERYYQIARCYRDEDFRADRQP-------EFTQLDMEM- 235 Query: 180 GNFDPMIPDAECLKIMCEILSSL 202 + + + I ++L ++ Sbjct: 236 ----SFVEADDVIAISEQVLKAV 254 >2ZNJ-A nrPDB Length = 308 Score = 36.3 bits (82), Expect = 0.029, Method: Composition-based stats. Identities = 22/142 (15%), Positives = 45/142 (31%), Gaps = 8/142 (5%) Query: 76 VFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDLTVPF 135 + + + + + G + TP K L + ++ LR L Sbjct: 96 LEEKLAKALHQQGFVQVVTPTIITKSALAKMTIGEDHPLFSQVFWLDGKKCLRPMLAPNL 155 Query: 136 A---RYLAMNKLTNIKRYHIAKVYRRDNPAMTRGRYREFYQCDFDIAGNFDPMIPDAECL 192 R L I+ + I YR+++ EF + G P+ + L Sbjct: 156 YTLWRELERLWDKPIRIFEIGTCYRKESQGAQH--LNEFTMLNLTELG--TPLEERHQRL 211 Query: 193 K-IMCEILSSLQIGDFLVKVND 213 + + +L + I +F + Sbjct: 212 EDMARWVLEAAGIREFELVTES 233 >1WLE-A nrPDB Length = 501 Score = 36.3 bits (82), Expect = 0.031, Method: Composition-based stats. Identities = 27/148 (18%), Positives = 48/148 (32%), Gaps = 24/148 (16%) Query: 76 VFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGED--------SKLIYDLKDQGGELLSL 127 + + + G + P + L G E IY++ E L+L Sbjct: 225 LVNFTLNKLIHRGFTPMTVP-----DLLRGVVFEGCGMTPNAKPSQIYNIDPSRFEDLNL 279 Query: 128 RYDLTVPFARYLAMN----KLTNIKRYHIAKVYRRDNPAMTR--GRYREFYQCDFDIAGN 181 V A Y + + I+ + YR + G YR + ++ G Sbjct: 280 AGTAEVGLAGYFMDHSVAFRDLPIRMVCSSTCYRAETDTGKEPWGLYRVHHFTKVEMFGV 339 Query: 182 FDPMIPDA-----ECLKIMCEILSSLQI 204 P + + E L + EIL+ L + Sbjct: 340 TGPGLEQSSELLEEFLSLQMEILTELGL 367 >2DU7-A nrPDB Length = 549 Score = 35.6 bits (80), Expect = 0.060, Method: Composition-based stats. Identities = 32/228 (14%), Positives = 74/228 (32%), Gaps = 47/228 (20%) Query: 31 IEEEVAKLLKLKAQLGPDESKQKFVLKTPKGTRDYSPRQMAVREKVF------------- 77 + E + +L + ++G +E ++ + + + P MAV ++ F Sbjct: 59 VMETIERLRQAYLRMGFEEMINPVIVDEMEIYKQFGPEAMAVLDRCFYLAGLPRPDVGLG 118 Query: 78 DVIIRCFKRHGA---EVIDTPVFELKETLMGKYGEDSKLIYD------------------ 116 + + K G E + E+ + L+++ Sbjct: 119 NEKVEIIKNLGIDIDEEKKERLREVLHLYKKGAIDGDDLVFEIAKALNVSNEMGLKVLET 178 Query: 117 ----LKDQGGEL--LSLRYDLTVP---FARYLAMNKLTNIKRYHIAKVYRRDNPAMTRGR 167 KD E L+LR +T L + +K + I + +RR+ R Sbjct: 179 AFPEFKDLKPESTTLTLRSHMTSGWFITLSSLIKKRKLPLKLFSIDRCFRREQRE-DRSH 237 Query: 168 YREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRR 215 ++ + G + D + + +L+ F K ++++ Sbjct: 238 LMSYHSASCVVVGEDVSVD-DGKVVA--EGLLAQFGFTKFKFKPDEKK 282 >5XIP-A nrPDB Length = 498 Score = 34.8 bits (78), Expect = 0.090, Method: Composition-based stats. Identities = 28/160 (17%), Positives = 50/160 (31%), Gaps = 22/160 (13%) Query: 60 KGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLK- 118 G P + E V KR G E P+F K ++ + K Sbjct: 33 SGCYIIRPWAYRIWEAVQKFFDDGIKRLGVENCYFPMF----VSQAKLEKEKDHVEGFKP 88 Query: 119 ------DQGG----ELLSLRYD----LTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMT 164 G E +++R + +A+++ ++ +K V R + T Sbjct: 89 EVAWVTHYGDSELPEKVAIRPTSETIMYPAYAKWIRSHRDLPLKLNQWNNVVRWEFKQPT 148 Query: 165 RG-RYREF-YQCDFDI-AGNFDPMIPDAECLKIMCEILSS 201 R REF +Q A + E L++ + Sbjct: 149 PFLRTREFLWQEGHTAHATEEEAYTLVLEILELYRQWYED 188 >2DJV-A nrPDB Length = 79 Score = 34.8 bits (78), Expect = 0.10, Method: Composition-based stats. Identities = 24/46 (52%), Positives = 26/46 (56%) Query: 6 ALEELVKLQGERVRGLKQQKASAELIEEEVAKLLKLKAQLGPDESK 51 AL + V QG VR LK QKA + EVAKLL LK QL E K Sbjct: 17 ALMDEVTKQGNIVRELKAQKADKNEVAAEVAKLLDLKKQLAVAEGK 62 >5XIG-A nrPDB Length = 500 Score = 34.4 bits (77), Expect = 0.12, Method: Composition-based stats. Identities = 17/109 (15%), Positives = 45/109 (41%), Gaps = 4/109 (3%) Query: 394 EQRLEALEEKIRTTETQVLVASAQKKLLEERL----KLVSELWDAGIKAELLYKKNPKLL 449 + + + ++ + + ++ + + E L +L + L A I+ + + N Sbjct: 275 DDKGLVIPPRVASVQVVIIPILFKDENTGEILGKCRELKTMLEKADIRVRIDDRSNYTPG 334 Query: 450 NQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDLVEEI 498 + + E G+PL +G ++L G ++ + E + DL ++ Sbjct: 335 WKYNHWEVKGVPLRLELGPKDLAKGTARVVRRDTGEAYQISWADLAPKL 383 >2ODR-C nrPDB Length = 701 Score = 32.9 bits (73), Expect = 0.37, Method: Composition-based stats. Identities = 21/110 (19%), Positives = 39/110 (35%), Gaps = 9/110 (8%) Query: 111 SKLIYDLKD--QGGELLSLRYDLTVP---FARYLAMNKLTNIKRYHIAKVYRRDNPAMTR 165 + + KD L+LR +T L K K + I + +RR+ + Sbjct: 184 EDVFPEFKDLTAVSSKLTLRSHMTSGWFLTVSDLMNKKPLPFKLFSIDRCFRREQKE-DK 242 Query: 166 GRYREFYQCDFDIAGNFDPMIPDAECLKIMCEILSSLQIGDFLVKVNDRR 215 ++ IAG I D + I +LS +F ++++ Sbjct: 243 SHLMTYHSASCAIAG-EGVDINDGK--AIAEGLLSQFGFTNFKFIPDEKK 289 >6M7Z-A nrPDB Length = 319 Score = 32.5 bits (72), Expect = 0.41, Method: Composition-based stats. Identities = 37/244 (15%), Positives = 72/244 (29%), Gaps = 30/244 (12%) Query: 90 EVIDTPVFELK--ETLMGKYGEDSKLIYDLKDQGGELLSLRYD----LTVPFARYLAMNK 143 + P+ + + + + G + + + LLSL + R + N Sbjct: 28 DESRNPILKRLLSGSFLRRDGSTTVNVRVPARELVRLLSLTPEQQREGVSAKVRLI--NL 85 Query: 144 LTNIKRYHIAKVYRRDNPAMTR------GRYRE------FYQCDFDIAG---NFDPMIPD 188 L + +YR P + G YR F+ + G PD Sbjct: 86 LDPKYSVYEPYLYREILPKRSPLLLPSLGEYRGAFLTYIFHPLSKGLVGDMLETGRSHPD 145 Query: 189 AECLKI----MCEILSSLQIGDFLVKVNDRRILDGMFAICGVSDSKFRTICSSVDKLDKV 244 + L + L +L + +++N +L + G D+ + + Sbjct: 146 VQVLAANMVAALKSLHNLGLLHRSIELNSFSVLPDGTVVLGGLDTAAPIGTETRLWVGFF 205 Query: 245 SWE---EVKNEMVGEKGLAPEVADRIGDYVQQHGGVSLVEQLLQDPKLSQNKQALEGLGD 301 E E+ + + L D + QLL + L + Sbjct: 206 GQETAPEIDRNFLADLALTQGRHTVKSDVYSLGVAFRNLVQLLGNGNLGPEDRGAVRQDH 265 Query: 302 LKLL 305 L+LL Sbjct: 266 LELL 269 >1CRU-A nrPDB Length = 454 Score = 32.5 bits (72), Expect = 0.49, Method: Composition-based stats. Identities = 25/108 (23%), Positives = 42/108 (38%), Gaps = 12/108 (11%) Query: 56 LKTPKGTRDYSPRQMAVREKVFDVIIRCFKRHGAEVID----TPVFELKETLMGKYGEDS 111 K PK T P Q +R ++ + + +D P + ++ G D Sbjct: 100 FKNPKSTDKELPNQTIIRRYTYNKSTDTLE----KPVDLLAGLPSSKDHQSGRLVIGPDQ 155 Query: 112 KLIYDLKDQGGELLSLRYDLTVPFARYLAMNKLTNIKRY--HIAKVYR 157 K+ Y + DQG L+ Y A++ + N K Y ++ KV R Sbjct: 156 KIYYTIGDQGRNQLA--YLFLPNQAQHTPTQQELNGKDYHTYMGKVLR 201 >4NCX-A nrPDB Length = 506 Score = 32.1 bits (71), Expect = 0.53, Method: Composition-based stats. Identities = 20/128 (15%), Positives = 53/128 (41%), Gaps = 5/128 (3%) Query: 379 CVGLSIGVERIFSIVEQRLEALEEKIRTTETQVLVASA---QKKLLEERLKLVSE-LWDA 434 C SIG+ I + + + L + + ++ + + K + + L +A Sbjct: 271 CTTRSIGI-MIMTHGDDKGLVLPPNVSKYKVVIVPIFYKTTDENAIHSYCKDIEKILKNA 329 Query: 435 GIKAELLYKKNPKLLNQLQYCEEAGIPLVAIIGEQELKDGVIKLRSVTSREEVDVRREDL 494 I + + + + E GIP+ +G ++L++ + + E+ +V++E + Sbjct: 330 QINCVYDDRASYSPGYKFNHWELRGIPIRIEVGPKDLQNNSCVIVRRDNNEKCNVKKESV 389 Query: 495 VEEIKRRT 502 + E ++ Sbjct: 390 LLETQQML 397 >5IJN-G nrPDB Length = 599 Score = 31.3 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 17/45 (37%), Positives = 20/45 (44%) Query: 341 LQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSIG 385 + T G LG +VAAGG G V F P VGL+ G Sbjct: 1 MSTGFSFGSGTLGSTTVAAGGTSTGGVFSFGTGASSNPSVGLNFG 45 >3A74-A nrPDB Length = 493 Score = 30.6 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 15/88 (17%), Positives = 30/88 (34%), Gaps = 8/88 (9%) Query: 72 VREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRYDL 131 R + + R HG ++TP+ G ++ + L +R + Sbjct: 176 TRSLIIQSMRRYLDSHGYLEVETPMMH-----AVAGGAAARPFITHHNALDMTLYMRIAI 230 Query: 132 TVPFARYLAMNKLTNIKRYHIAKVYRRD 159 + R + K Y I +V+R + Sbjct: 231 ELHLKRLIVGGLE---KVYEIGRVFRNE 255 >5ZG8-A nrPDB Length = 438 Score = 30.2 bits (66), Expect = 2.2, Method: Composition-based stats. Identities = 18/96 (18%), Positives = 32/96 (33%), Gaps = 10/96 (10%) Query: 70 MAVREKVFDVIIRCFKRHGAEVIDTPVFELKETLMGKYGEDSKLIYDLKDQGGELLSLRY 129 M +R+++ I F G D P+ L E + +++++ GE L Sbjct: 131 MRIRDELERAIHEFFGERGFLRFDAPI------LTPSAVEGTTELFEVELFDGEKAYLSQ 184 Query: 130 DLTVPFARYLAMNKLTNIKRYHIAKVYRRDNPAMTR 165 + Y L K Y +R + R Sbjct: 185 SGQL----YAEAGALAFAKVYTFGPTFRAERSKTRR 216 >6OTE-A nrPDB Length = 572 Score = 30.2 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 30/152 (19%), Positives = 50/152 (32%), Gaps = 22/152 (14%) Query: 88 GAEVIDTPVFELKETLMGKYGEDSKLIYDLKD------QG---GELLSLRYDLTVPFARY 138 G I P F ++ MGK E L +G L L P A Sbjct: 318 GYLAIQPPYFMKRDL-MGKAAELQDFEETLYHIPSDNSKGEVDSNSLFLIATSEQPIAAM 376 Query: 139 ----LAMNKLTNIKRYHIAKVYRRDNPAMTR---GRYREFYQCD-FDIAGNFDPMIPDA- 189 +K IK I+ +R++ A + G +R +Q + + P Sbjct: 377 HHNVTLEDKDLPIKYAGISTCFRKEAGAHGKDTWGIFR-IHQFEKVEQFCVTLPEDSQKI 435 Query: 190 --ECLKIMCEILSSLQIGDFLVKVNDRRILDG 219 E + I E SL++ ++ + + D Sbjct: 436 HEEMISISEEFYQSLELPYRVISIVSGALNDA 467 >3MMP-A nrPDB Length = 678 Score = 28.6 bits (62), Expect = 6.1, Method: Composition-based stats. Identities = 20/62 (32%), Positives = 31/62 (50%), Gaps = 6/62 (9%) Query: 1 MAERAALEELVK-----LQGERVRGLKQQKASAELIEEEVAKLLKLKAQLG-PDESKQKF 54 +A + A EELVK + + +K + SAE++E+E L + Q G P E +K Sbjct: 156 VAAKGADEELVKHIAMHVAASKPEFIKPEDVSAEVVEKEYQVQLDIAMQSGKPKEIAEKM 215 Query: 55 VL 56 V Sbjct: 216 VE 217 >5OQL-Y nrPDB Length = 411 Score = 28.2 bits (61), Expect = 7.7, Method: Composition-based stats. Identities = 18/106 (16%), Positives = 38/106 (35%) Query: 325 ARGLDYYTGVIYEAVLLQTPAQAGEEPLGVGSVAAGGRYDGLVGMFDPKGRKVPCVGLSI 384 RG+ Y TGV A G V V +YD + + + G+ Sbjct: 218 IRGVAYCTGVAASHNNRMITAARGVLNQLVSDVHIAAQYDPAPLVAEKGTTQKKKTGIGF 277 Query: 385 GVERIFSIVEQRLEALEEKIRTTETQVLVASAQKKLLEERLKLVSE 430 G+ + + + +++ E V+ +K + L ++++ Sbjct: 278 GLSLVAETSAEGVIYAADEVAPPEGGVVPEDIGEKCAYQLLDVIAQ 323 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.122 0.292 Lambda K H 0.267 0.0373 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,055,812 Number of Sequences: 36641 Number of extensions: 619348 Number of successful extensions: 2401 Number of sequences better than 10.0: 60 Number of HSP's better than 10.0 without gapping: 49 Number of HSP's successfully gapped in prelim test: 55 Number of HSP's that attempted gapping in prelim test: 2176 Number of HSP's gapped (non-prelim): 127 length of query: 509 length of database: 10,336,785 effective HSP length: 101 effective length of query: 408 effective length of database: 6,636,044 effective search space: 2707505952 effective search space used: 2707505952 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 61 (28.2 bits)