BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P11926 (461 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1D7K-A nrPDB 878 0.0 7ODC-A nrPDB 817 0.0 1NJJ-A nrPDB 571 e-163 4ZGZ-A nrPDB 454 e-128 2NV9-A nrPDB 277 7e-75 4AIB-A nrPDB 227 8e-60 5GJN-A nrPDB 213 1e-55 2PLJ-A nrPDB 199 2e-51 2P3E-A nrPDB 112 4e-25 2QGH-A nrPDB 102 3e-22 2YXX-A nrPDB 96 2e-20 3N2B-A nrPDB 88 1e-17 3VAB-A nrPDB 86 5e-17 1TWI-A nrPDB 83 3e-16 4XG1-A nrPDB 77 1e-14 2J66-A nrPDB 73 3e-13 5X7M-A nrPDB 71 1e-12 1HKV-A nrPDB 57 1e-08 1KNW-A nrPDB 48 9e-06 3N29-A nrPDB 44 1e-04 3MT1-A nrPDB 43 2e-04 3N2O-A nrPDB 33 0.28 3NZQ-A nrPDB 32 0.42 3KVS-A nrPDB 32 0.48 2V1C-A nrPDB 32 0.85 5V5P-C nrPDB 31 1.1 4ATE-A nrPDB 30 1.6 4HDR-B nrPDB 28 6.8 3IHL-A nrPDB 28 7.4 1SMS-A nrPDB 28 9.2 >1D7K-A nrPDB Length = 421 Score = 878 bits (2269), Expect = 0.0, Method: Compositional matrix adjust. Identities = 420/421 (99%), Positives = 421/421 (100%) Query: 7 EEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFY 66 EEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFY Sbjct: 1 EEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFY 60 Query: 67 AVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANN 126 AVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANN Sbjct: 61 AVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANN 120 Query: 127 GVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKE 186 GVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKE Sbjct: 121 GVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKE 180 Query: 187 LNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKL 246 LNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKL Sbjct: 181 LNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKL 240 Query: 247 KFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDE 306 KFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDE Sbjct: 241 KFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDE 300 Query: 307 DESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRI 366 DESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDE+YYSSSIWGPTCDGLDRI Sbjct: 301 DESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDERYYSSSIWGPTCDGLDRI 360 Query: 367 VERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDFP 426 VERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDFP Sbjct: 361 VERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDFP 420 Query: 427 P 427 P Sbjct: 421 P 421 >7ODC-A nrPDB Length = 424 Score = 817 bits (2111), Expect = 0.0, Method: Compositional matrix adjust. Identities = 387/422 (91%), Positives = 403/422 (95%) Query: 1 MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALP 60 M++F +EFDCH LDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALP Sbjct: 1 MSSFTKDEFDCHILDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALP 60 Query: 61 RVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQI 120 RVTPFYAVKCNDS+AIV TLAA GTGFDCASKTEIQLVQ LGVP ER+IYANPCKQVSQI Sbjct: 61 RVTPFYAVKCNDSRAIVSTLAAIGTGFDCASKTEIQLVQGLGVPAERVIYANPCKQVSQI 120 Query: 121 KYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLL 180 KYAA+NGVQMMTFDSE+ELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATL+TSRLL Sbjct: 121 KYAASNGVQMMTFDSEIELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLKTSRLL 180 Query: 181 LERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPG 240 LERAKELNIDV+GVSFHVGSGCTDP+TFVQA+SDARCVFDM EVGFSM+LLDIGGGFPG Sbjct: 181 LERAKELNIDVIGVSFHVGSGCTDPDTFVQAVSDARCVFDMATEVGFSMHLLDIGGGFPG 240 Query: 241 SEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQ 300 SED KLKFEEIT VINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKK V KEQ Sbjct: 241 SEDTKLKFEEITSVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKTVWKEQ 300 Query: 301 TGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTC 360 GSDDEDES+EQTFMYYVNDGVYGSFNCILYDHAHVK LLQKRPKPDEKYYSSSIWGPTC Sbjct: 301 PGSDDEDESNEQTFMYYVNDGVYGSFNCILYDHAHVKALLQKRPKPDEKYYSSSIWGPTC 360 Query: 361 DGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQF 420 DGLDRIVERC+LPEMHVGDWMLFENMGAYTVAAASTFNGFQRP IYYVMS P WQLM+Q Sbjct: 361 DGLDRIVERCNLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPNIYYVMSRPMWQLMKQI 420 Query: 421 QN 422 Q+ Sbjct: 421 QS 422 >1NJJ-A nrPDB Length = 425 Score = 571 bits (1472), Expect = e-163, Method: Compositional matrix adjust. Identities = 274/417 (65%), Positives = 333/417 (79%), Gaps = 2/417 (0%) Query: 6 NEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPF 65 N++ C FL EGF +D L +KI+ +++ D+ D F+VADLGDI++KH W K LPRVTPF Sbjct: 8 NDDLSCRFL-EGFNTRDALCKKIS-MNTCDEGDPFFVADLGDIVRKHETWKKCLPRVTPF 65 Query: 66 YAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAAN 125 YAVKCND ++ TLAA GTGFDCAS TEIQ V+ +GVPPE+IIYANPCKQ+S I+YA + Sbjct: 66 YAVKCNDDWRVLGTLAALGTGFDCASNTEIQRVRGIGVPPEKIIYANPCKQISHIRYARD 125 Query: 126 NGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAK 185 +GV +MTFD EL KVA+ HPKAK+VLRI+TDDS A CRLSVKFGA + R +LE+AK Sbjct: 126 SGVDVMTFDCVDELEKVAKTHPKAKMVLRISTDDSLARCRLSVKFGAKVEDCRFILEQAK 185 Query: 186 ELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVK 245 +LNIDV GVSFHVGSG TD TF QAISD+R VFDMG E+GF+M++LDIGGGFPG+ D Sbjct: 186 KLNIDVTGVSFHVGSGSTDASTFAQAISDSRFVFDMGTELGFNMHILDIGGGFPGTRDAP 245 Query: 246 LKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDD 305 LKFEEI GVIN AL+K+FP D + I+AEPGRYYVASAFTLAVN+IAKK+ QT Sbjct: 246 LKFEEIAGVINNALEKHFPPDLKLTIVAEPGRYYVASAFTLAVNVIAKKVTPGVQTDVGA 305 Query: 306 EDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDR 365 ES+ Q+FMYYVNDGVYGSFNCILYDHA V+PL Q+ P P+EK Y SS+WGPTCDGLD+ Sbjct: 306 HAESNAQSFMYYVNDGVYGSFNCILYDHAVVRPLPQREPIPNEKLYPSSVWGPTCDGLDQ 365 Query: 366 IVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQN 422 IVER LPEM VG+W+LFE+MGAYTV S+FNGFQ PTIYYV+SG ++++ ++ Sbjct: 366 IVERYYLPEMQVGEWLLFEDMGAYTVVGTSSFNGFQSPTIYYVVSGLPDHVVRELKS 422 >4ZGZ-A nrPDB Length = 438 Score = 454 bits (1169), Expect = e-128, Method: Compositional matrix adjust. Identities = 223/413 (53%), Positives = 292/413 (70%), Gaps = 17/413 (4%) Query: 13 FLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCND 72 LDEG +++D + E + + K+AF+V DLG I+KKH +W + ++ PFY VKCN Sbjct: 15 LLDEGTDLGNVIDNYVYEHTLTG-KNAFFVGDLGKIVKKHSQWQNVVAQIKPFYTVKCNS 73 Query: 73 SKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMT 132 + A+++ LAA GTGF C+SK E+ LVQ LGVPPE IIY +PCKQVSQIKYAA GV ++T Sbjct: 74 APAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILT 133 Query: 133 FDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVV 192 D+E+EL K+AR HP AK++L IAT+D+ ++KFG TL+ R LLE AKEL++ ++ Sbjct: 134 CDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHLLECAKELDVQII 193 Query: 193 GVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEIT 252 GV FHV S C + + +V A+SDARCVFDM E+GF+M +LDIGGGF G+E + EE+ Sbjct: 194 GVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGTE---FQLEEVN 250 Query: 253 GVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLK-------EQTGSDD 305 VI+P LD YFP SGV+II+EPG YYV+SAFTLAVNIIAKK+V E+TGSD Sbjct: 251 HVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSD- 309 Query: 306 EDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDR 365 E FMYY+NDGVYGSF L + + P + K+ K DE ++SS+WGP+CD LD+ Sbjct: 310 -----EPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQ 364 Query: 366 IVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQ 418 IVE C LPE++VGDW++F+NMGA + S FN FQRP IYY+MS W MQ Sbjct: 365 IVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQ 417 >2NV9-A nrPDB Length = 372 Score = 277 bits (708), Expect = 7e-75, Method: Compositional matrix adjust. Identities = 139/355 (39%), Positives = 205/355 (57%), Gaps = 15/355 (4%) Query: 54 RWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANP 113 +W PRVTP YAVKCN+ + ++KT+ FDCAS +EI+ V +GV P RII+A+ Sbjct: 33 QWTILFPRVTPHYAVKCNNDEVLLKTMCDKNVNFDCASSSEIKKVIQIGVSPSRIIFAHT 92 Query: 114 CKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGAT 173 K + + +A + GV + TFDS EL K+ HP K++LRI DD A +L KFGA Sbjct: 93 MKTIDDLIFAKDQGVDIATFDSSFELDKIHTYHPNCKMILRIRCDDPNAAVQLGNKFGAN 152 Query: 174 LRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLD 233 R LLE AK+L+I+V+G+SFHVGSG +PE + +AI ++ F+ VG Y+LD Sbjct: 153 EDEIRHLLEYAKQLDIEVIGISFHVGSGSRNPEAYYRAIKSSKEAFNEAISVGHKPYILD 212 Query: 234 IGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAK 293 IGGG D ++ IN A+ +FP D+ V I+AEPGR++ LA +I K Sbjct: 213 IGGGLHADIDEGELSTYMSDYINDAIKDFFPEDT-VTIVAEPGRFFAEHYSVLATQVIGK 271 Query: 294 KIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSS 353 ++ + + Y+ N+ YG F+ ++++ + P L + DE+Y S Sbjct: 272 RV--------------RDGLYEYFFNESTYGGFSNVIFEKSVPTPQLLRDVPDDEEYVPS 317 Query: 354 SIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYV 408 ++G TCDG+D I LPE+H+GDW+ F + GAYT ++FNGF +YY+ Sbjct: 318 VLYGCTCDGVDVINHNVALPELHIGDWVYFPSWGAYTNVLTTSFNGFGEYDVYYI 372 >4AIB-A nrPDB Length = 395 Score = 227 bits (578), Expect = 8e-60, Method: Compositional matrix adjust. Identities = 133/395 (33%), Positives = 211/395 (53%), Gaps = 21/395 (5%) Query: 28 INEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGF 87 I++ + F++ D + K RW K +P V P +AVKCN +VK L G GF Sbjct: 16 ISQFEPENQPLGFWIFDTEGVEKAVERWKKNMPTVRPCFAVKCNPEPHLVKLLGELGCGF 75 Query: 88 DCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHP 147 DCAS EI+ V LG PE I Y+ K +Q+ A++ G+ DS E+ K+A+ P Sbjct: 76 DCASLNEIKEVLDLGFNPEDITYSQTFKPYNQLIEASHLGINHTIVDSIDEVQKIAKYAP 135 Query: 148 KAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPET 207 K +++RI +D+ A KFG ++L+ K+ +++ GV FHVGS + E Sbjct: 136 KMGIMIRIMENDTSAGHVFGEKFGLHDDEVEIVLKEIKDKGLNLDGVHFHVGSDSHNSEV 195 Query: 208 FVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKY-FPSD 266 F +A++ AR + + G YL+DIGGGF FEE I + + FP Sbjct: 196 FTKALTKARNTVTLAEQFGMKPYLIDIGGGFSQV----APFEEFAATIEKTIKELEFPER 251 Query: 267 SGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSF 326 + R IAEPGRY ++AF L ++ K++ + ++ ++ Y DG++GSF Sbjct: 252 T--RFIAEPGRYMASNAFHLVSSLHGKRVRI----------QNGKKQIEYTSGDGLHGSF 299 Query: 327 N-CILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVG-DWMLFE 384 CI ++ + ++ + K Y S I+GP+C+G D++ + +LPEM G DW+LF Sbjct: 300 GCCIWFEKQKSCECITQKVNENTKMYESIIYGPSCNGSDKVATQ-ELPEMEPGKDWLLFP 358 Query: 385 NMGAYTVAAASTFNGF-QRPTIYYVMSGPAWQLMQ 418 NMGAYT++ A+ FNGF +R + Y + + +++Q Sbjct: 359 NMGAYTISMATNFNGFEERNHVIYTLPLKSTKIIQ 393 >5GJN-A nrPDB Length = 393 Score = 213 bits (543), Expect = 1e-55, Method: Compositional matrix adjust. Identities = 129/375 (34%), Positives = 201/375 (53%), Gaps = 32/375 (8%) Query: 40 FYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQ 99 F VA L + + + + LPR FYA+K N + I+ LA G+ FD AS E++++ Sbjct: 22 FLVASLDKVEENYQFMRRHLPRAGVFYAMKANPTPEILSLLAGLGSHFDVASAGEMEILH 81 Query: 100 SLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDD 159 LGV ++IYANP K +K AA+ V+ TFD E+ K+A+A P A +++RIA + Sbjct: 82 ELGVDGSQMIYANPVKDARGLKAAADYNVRRFTFDDPSEIDKMAKAVPGADVLVRIAVRN 141 Query: 160 SKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVF 219 +KA+ L+ KFGA + + LL+ A++ + +G+ FHVGS + +A+ AR +F Sbjct: 142 NKALVDLNTKFGAPVEEALDLLKAAQDAGLHAMGICFHVGSQSLSTAAYEEALLVARRLF 201 Query: 220 DMGAEVGFSMYLLDIGGGF--PGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGR 277 D E+G + LDIGGGF P ++ + + + IN +D+ FP + + EPGR Sbjct: 202 DEAEEMGMHLTDLDIGGGFPVPDAKGLNVDLAAMMEAINKQIDRLFPDTA---VWTEPGR 258 Query: 278 YYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDH---- 333 Y +A L ++I K EQ + Y +++G+YG F+ I+YDH Sbjct: 259 YMCGTAVNLVTSVIGTKT-------------RGEQPW-YILDEGIYGCFSGIMYDHWTYP 304 Query: 334 AHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAA 393 H K+P S+ GP+CDG+D + PE+ +GD +L MG+YT + Sbjct: 305 LHCFGKGNKKP--------STFGGPSCDGIDVLYRDFMAPELKIGDKVLVTEMGSYTSVS 356 Query: 394 ASTFNGFQ-RPTIYY 407 A+ FNGF PTI + Sbjct: 357 ATRFNGFYLAPTIIF 371 >2PLJ-A nrPDB Length = 419 Score = 199 bits (507), Expect = 2e-51, Method: Compositional matrix adjust. Identities = 128/359 (35%), Positives = 195/359 (54%), Gaps = 23/359 (6%) Query: 47 DILKKHLRWLK-ALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPP 105 D++++ R LK ALP VT YA+K +V+TL A G FD A+ E++LV S GVP Sbjct: 63 DVIRQQYRALKNALPNVTLHYALKPLPHPVVVRTLLAEGASFDLATTGEVELVASEGVPA 122 Query: 106 ERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCR 165 + I+ +P K+ + I+ A G + D+ EL K +L++R++ +S+A Sbjct: 123 DLTIHTHPIKRDADIRDALAYGCNVFVVDNLNELEKFKAYRDDVELLVRLSFRNSEAFAD 182 Query: 166 LSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEV 225 LS KFG + + +++E AKE NI + G+SFHVGS T+P +V+AI R V + E Sbjct: 183 LSKKFGCSPEQALVIIETAKEWNIRIKGLSFHVGSQTTNPNKYVEAIHTCRHVMEQVVER 242 Query: 226 GF-SMYLLDIGGGFPGSEDVK-LKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASA 283 G ++ LDIGGGFP + + + ++ IN AL P V ++AEPGR+ A A Sbjct: 243 GLPALSTLDIGGGFPVNYTQQVMPIDQFCAPINEAL-SLLPET--VHVLAEPGRFICAPA 299 Query: 284 FTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKR 343 T +++ + E YY++DG+YGSF+ +++D A PL Sbjct: 300 VTSVASVMGQA--------------EREGQIWYYLDDGIYGSFSGLMFDDARY-PL--TT 342 Query: 344 PKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQR 402 K + S + GPTCD +D I E LP+++ GD ++ MGAYT A A+ FN F+R Sbjct: 343 IKQGGELIPSVLSGPTCDSVDVIAENILLPKLNNGDLVIGRTMGAYTSATATDFNFFKR 401 >2P3E-A nrPDB Length = 420 Score = 112 bits (280), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 106/400 (26%), Positives = 181/400 (45%), Gaps = 37/400 (9%) Query: 40 FYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQ 99 YV I ++ + KA P YAVK N + +VK L G G D S E+ L + Sbjct: 36 LYVYSSNFIKERFEAYRKAFPDALICYAVKANFNPHLVKLLGELGAGADIVSGGELYLAK 95 Query: 100 SLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKV----ARAHPKAKLVLRI 155 G+PPERI+YA K ++ A ++ + M +S EL + + KA++ +R+ Sbjct: 96 KAGIPPERIVYAGVGKTEKELTDAVDSEILMFNVESRQELDVLNEIAGKLGKKARIAIRV 155 Query: 156 ATD-DSK-----AVCRLSVKFGATLRTSRLLLERAKEL-NIDVVGVSFHVGSGCTDPETF 208 D D K A KFG +R ++ E A +L N+++VG+ H+GS D + Sbjct: 156 NPDVDPKTHPYIATGMQKSKFGVDIREAQKEYEYASKLENLEIVGIHCHIGSQILDISPY 215 Query: 209 VQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSG 268 +A+ +++ + GF + LDIGGG +K K E+ D Sbjct: 216 REAVEKVVSLYESLTQKGFDIKYLDIGGGL----GIKYKPEDKEPAPQDLADLLKDLLEN 271 Query: 269 V--RIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSF 326 V +II EPGR + +A L + K D+ S+ + V+ G+ Sbjct: 272 VKAKIILEPGRSIMGNAGILITQVQFLK------------DKGSKHFII--VDAGMNDLI 317 Query: 327 NCILYD-HAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFEN 385 +Y+ + H+ P+ K + K + I GP C+ D + ++ E+ G+++ + Sbjct: 318 RPSIYNAYHHIIPVETK----ERKKVVADIVGPICETGDFLALDREIEEVQRGEYLAVLS 373 Query: 386 MGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDF 425 GAY A +S +N R V +G + +L+++ +N D+ Sbjct: 374 AGAYGFAMSSHYNMRPRAAEVLVENG-SVKLIRKRENYDY 412 >2QGH-A nrPDB Length = 425 Score = 102 bits (255), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 98/388 (25%), Positives = 164/388 (42%), Gaps = 46/388 (11%) Query: 37 KDAFYVADLGDILKKHLRWLKALPRVTPF--YAVKCNDSKAIVKTLAATGTGFDCASKTE 94 K FY+ D I + L + +A YA+K N + +I+ LA +G DC S E Sbjct: 32 KTPFYLYDFDKIKQAFLNYKEAFKGRKSLICYALKANSNLSILSLLAHLESGADCVSIGE 91 Query: 95 IQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHP----KAK 150 IQ G+ P RI+++ K +I+ A + + +S +EL + KA+ Sbjct: 92 IQRALKAGIKPYRIVFSGVGKSAFEIEQALKLNILFLNVESFMELKTIETIAQSLGIKAR 151 Query: 151 LVLRIATD-DSKAVCRLSV-----KFGATLRTS-RLLLERAKELNIDVVGVSFHVGSGCT 203 + +RI + D+K +S KFG + + + L K ++ V V FH+GS Sbjct: 152 ISIRINPNIDAKTHPYISTGLKENKFGVGEKEALEMFLWAKKSAFLEPVSVHFHIGSQLL 211 Query: 204 DPETFVQAISDARCVFDMGAEVGFSMYLLDIGGG----FPGSEDVKLKFEEITGVINP-- 257 D E ++A + +G + D+GGG + E +KL ++ G++N Sbjct: 212 DLEPIIEASQKVAKIAKSLIALGIDLRFFDVGGGIGVSYENEETIKL-YDYAQGILNALQ 270 Query: 258 ALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYY 317 LD + II EPGR VA + L ++ +K ++ Sbjct: 271 GLD--------LTIICEPGRSIVAESGELITQVLYEK--------------KAQNKRFVI 308 Query: 318 VNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHV 377 V+ G+ LY H ++ P + + GP C+ D ++ LPE+ Sbjct: 309 VDAGMNDFLRPSLYHAKHAIRVIT--PSKGREISPCDVVGPVCESSDTFLKDAHLPELEP 366 Query: 378 GDWMLFENMGAYTVAAASTFNGFQRPTI 405 GD + E +GAY + AS +N RP + Sbjct: 367 GDKIAIEKVGAYGSSMASQYN--SRPKL 392 >2YXX-A nrPDB Length = 386 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 99/387 (25%), Positives = 165/387 (42%), Gaps = 48/387 (12%) Query: 47 DILKKHLRWLKAL---PRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGV 103 + L+K R +K + + P +AVK N++ ++K L G G D +K E+ + GV Sbjct: 21 ETLRKRSRLVKEVFEGVNLLPTFAVKANNNPVLLKILREEGFGMDVVTKGELLAAKLAGV 80 Query: 104 PPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKA-KLVLRIATD-DSK 161 P +++ K Q+++ V+++ DS E+ +P+ + +R+ + D+K Sbjct: 81 PSHTVVWNGNGKSRDQMEHFLREDVRIVNVDSFEEMEIWRELNPEGVEYFIRVNPEVDAK 140 Query: 162 AVCRLSV-----KFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDAR 216 +S KFG L +ER + +NI G+ H+GS T E FV+A S Sbjct: 141 THPHISTGLKKHKFGIPLEDLDSFMERFRSMNIR--GLHVHIGSQITRVEPFVEAFSK-- 196 Query: 217 CVFDMGAEVGFSMYLLDIGGG----FPGSEDVKLKFEEITGVINPALDKYFPSDSGVRII 272 V GF ++IGGG + G E L + P L ++ R+I Sbjct: 197 -VVRASERYGFEE--INIGGGWGINYSGEE---LDLSSYREKVVPDLKRF------KRVI 244 Query: 273 AEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYD 332 E GRY VA + L + ++ K + F+ V+ G+ LY Sbjct: 245 VEIGRYIVAPSGYLLLRVVLVK-------------RRHNKAFV-VVDGGMNVLIRPALYS 290 Query: 333 HAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVA 392 H +L K+ K + + GP C+ D I +LPE+ GD + EN GAY Sbjct: 291 AYHRIFVLGKQGKE----MRADVVGPLCESGDVIAYDRELPEVEPGDIIAVENAGAYGYT 346 Query: 393 AASTFNGFQRPTIYYVMSGPAWQLMQQ 419 ++ +N RP V L+++ Sbjct: 347 MSNNYNSTTRPAEVLVRENGRISLIRR 373 >3N2B-A nrPDB Length = 441 Score = 87.8 bits (216), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 94/358 (26%), Positives = 156/358 (43%), Gaps = 39/358 (10%) Query: 66 YAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAAN 125 YAVK N + ++ TLA G+GFD S E++ V + G P +++++ K +++K A Sbjct: 82 YAVKANSNLGVLNTLARLGSGFDIVSVGELERVLAAGGDPSKVVFSGVGKTEAEMKRALQ 141 Query: 126 NGVQMMTFDSEVELMKVARAHP----KAKLVLRIATD-DSKAVCRLSV-----KFGATLR 175 ++ +SE EL ++ + KA + LRI D D+K +S KFG T Sbjct: 142 LKIKCFNVESEPELQRLNKVAGELGVKAPISLRINPDVDAKTHPYISTGLRDNKFGITFD 201 Query: 176 TSRLLLERAKEL-NIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDI 234 + + A L N+DV G+ H+GS T F+ A + D G + LD+ Sbjct: 202 RAAQVYRLAHSLPNLDVHGIDCHIGSQLTALAPFIDATDRLLALIDSLKAEGIHIRHLDV 261 Query: 235 GGGFPG--SEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIA 292 GGG +++ + E + L+++ + +I EPGR A+A L + Sbjct: 262 GGGLGVVYRDELPPQPSEYAKALLDRLERH----RDLELIFEPGRAIAANAGVL----VT 313 Query: 293 KKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAH-VKPLLQKRPKPDEKYY 351 K LK +E ++ + LY + PL RP+ E Sbjct: 314 KVEFLKH----------TEHKNFAIIDAAMNDLIRPALYQAWQDIIPL---RPRQGEA-Q 359 Query: 352 SSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVM 409 + + GP C+ D + + DL + GD + + GAY +S +N RP + VM Sbjct: 360 TYDLVGPVCETSDFLGKDRDLV-LQEGDLLAVRSSGAYGFTMSSNYN--TRPRVAEVM 414 >3VAB-A nrPDB Length = 443 Score = 85.5 bits (210), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 97/351 (27%), Positives = 153/351 (43%), Gaps = 41/351 (11%) Query: 66 YAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAAN 125 YA+K N ++A++ LA G G D S+ EI+ + G+P RI+++ K ++ +A Sbjct: 79 YALKANSNQAVLTALAKLGAGADTVSQGEIRRALAAGIPANRIVFSGVGKTPREMDFALE 138 Query: 126 NGVQMMTFDSEVEL-MKVARAHPKAKLV---LRIATD-DSKAVCRLSV-----KFGATLR 175 G+ +SE EL + ARA K+ LRI D D+K ++S KFG Sbjct: 139 AGIYCFNVESEPELEILSARAVAAGKVAPVSLRINPDVDAKTHAKISTGKSENKFGIPRD 198 Query: 176 TSRLLLERAKEL-NIDVVGVSFHVGSGCTDPETFVQAIS-DARCVFDMGAEVGFSMYLLD 233 +R RA L ++VVG+ H+GS D E F A + A V ++ A+ G ++ +D Sbjct: 199 KARAAYARAASLPGLNVVGIDMHIGSQIIDLEPFDNAFALMAELVKELQAD-GHNIRHVD 257 Query: 234 IGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAK 293 +GGG G V + G++ + EPGR V +A L +I Sbjct: 258 VGGGL-GIPYRTPNTPPPPPVAYAQIVAKHIKPLGLKTVFEPGRLIVGNAGLLVTEVIFV 316 Query: 294 KIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAH-VKPLLQKRPKPDEKYYS 352 K E + F+ V+ + LYD H ++P++ P + Sbjct: 317 K-------------EGDAKNFVI-VDAAMNDLIRPTLYDAFHDIRPVIM--PNDNAPRIR 360 Query: 353 SSIWGPTCD-----GLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFN 398 + GP C+ GLDR V + GD + GAY +ST+N Sbjct: 361 ADFVGPVCETGDYLGLDREVAKP-----APGDLIAICTTGAYGAVLSSTYN 406 >1TWI-A nrPDB Length = 434 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 90/363 (24%), Positives = 156/363 (42%), Gaps = 48/363 (13%) Query: 66 YAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAAN 125 YA K N + AI + LA G G D S E+ + + VP ++I++ CK +I Sbjct: 66 YAYKANANLAITRLLAKLGCGADVVSGGELYIAKLSNVPSKKIVFNGNCKTKEEIIMGIE 125 Query: 126 NGVQMMTFDSEVELMKVA--------------RAHPKA--KLVLRIATDDSKAVCRLSVK 169 ++ DS EL+ + R +P K +I+T K L V+ Sbjct: 126 ANIRAFNVDSISELILINETAKELGETANVAFRINPNVNPKTHPKISTGLKKNKFGLDVE 185 Query: 170 FGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEV---G 226 G ++ ++ LE ++VVGV H+GS TD F++ + R V D E+ G Sbjct: 186 SGIAMKAIKMALEMEY---VNVVGVHCHIGSQLTDISPFIE---ETRKVMDFVVELKEEG 239 Query: 227 FSMYLLDIGGGF--PGSEDVKLKFEE--ITGVINPALDKYFPSDSGVRIIAEPGRYYVAS 282 + +++GGG P +D ++ ++ +IN L KY +I EPGR VA+ Sbjct: 240 IEIEDVNLGGGLGIPYYKDKQIPTQKDLADAIINTML-KYKDKVEMPNLILEPGRSLVAT 298 Query: 283 AFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQK 342 A L G + + T ++ G+ +Y+ H ++ Sbjct: 299 AGYL--------------LGKVHHIKETPVTKWVMIDAGMNDMMRPAMYEAYH--HIINC 342 Query: 343 RPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQR 402 + K +++ SI G C+ D +L ++ VGD + ++GAY ++ A+ +N R Sbjct: 343 KVKNEKEVV--SIAGGLCESSDVFGRDRELDKVEVGDVLAIFDVGAYGISMANNYNARGR 400 Query: 403 PTI 405 P + Sbjct: 401 PRM 403 >4XG1-A nrPDB Length = 427 Score = 77.4 bits (189), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 89/349 (25%), Positives = 160/349 (45%), Gaps = 37/349 (10%) Query: 66 YAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAAN 125 YAVK N + A++ +A G+GFD S E+ V G P++I+++ K +I A Sbjct: 58 YAVKANSNLAVLNLMARMGSGFDIVSVGELMRVIQAGGDPKKIVFSGVGKTEIEISAALQ 117 Query: 126 NGVQMMTFDSEVELMK---VARA-HPKAKLVLRIATD-DSKAVCRLSV-----KFGATLR 175 + +S EL + VA+A + KA + +RI + D+ +S KFG + Sbjct: 118 ANIMCFNVESISELYRINSVAKALNVKAPISIRINPNIDAGTHPYISTGLKENKFGIEIE 177 Query: 176 TSRLLLERAKELN-IDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDI 234 + + + A +L +++ GV H+GS T+ F++A+ + D+ AE G ++ LD+ Sbjct: 178 QALDVYKIASDLEFLEIKGVDCHIGSQLTEIAPFIEALDKLLILIDLLAEKGITISHLDL 237 Query: 235 GGGFPGSEDVKL---KFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNII 291 GGG D + E +T +IN + +++I EPGR +A+A L + Sbjct: 238 GGGLGVPYDDETPPEPAEYMTAIINRMAGR------SLKLIFEPGRAIMANAGVLVTKVE 291 Query: 292 AKKIVLKEQTGSDDEDESSEQTFMY-YVNDGVYGSFNCILYDHAHVKPL-LQKRPKPDEK 349 K+ +D ++ + M + +Y ++ I+ PL + D Sbjct: 292 FLKL-------NDYKNFAIVDAAMNDLIRPALYSAWQNII-------PLNTDYQDGQDRP 337 Query: 350 YYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFN 398 S I GP C+ D + + L + GD+++ + GAY +S +N Sbjct: 338 VRSYDIVGPICETGDFLGKERQLA-LAEGDYLVIRSTGAYGSTMSSNYN 385 >2J66-A nrPDB Length = 428 Score = 72.8 bits (177), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 85/393 (21%), Positives = 163/393 (41%), Gaps = 73/393 (18%) Query: 40 FYVADLGDILKKHLRWLKAL--PRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQL 97 FY+ D GD ++ H R L++ P + + ++K N++ + K G G + AS E+ L Sbjct: 19 FYLYD-GDFIEAHYRQLRSRTNPAIQFYLSLKANNNIHLAKLFRQWGLGVEVASAGELAL 77 Query: 98 VQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPK----AKLVL 153 + G E II++ P K+ S+++ A +G+ + +S EL + K A++ + Sbjct: 78 ARHAGFSAENIIFSGPGKKRSELEIAVQSGIYCIIAESVEELFYIEELAEKENKTARVAI 137 Query: 154 RIATDDSKAVCRLSVKFGATLRTSRL-------LLERAKELNI-DVVGVSFHVGSGCTDP 205 RI D K+ ++K G R + +++ + L +G+ + G+ + Sbjct: 138 RINPD--KSFGSTAIKMGGVPRQFGMDESMLDAVMDAVRSLQFTKFIGIHVYTGTQNLNT 195 Query: 206 ETFVQAISDARCVFDMGAEV----GFSMYLLDIGGGFP---GSEDVKLKFEEITGVIN-- 256 ++ ++++ + D+G + G +++GGGF S + L +IT ++ Sbjct: 196 DSIIESM---KYTVDLGRNIYERYGIVCECINLGGGFGVPYFSHEKALDIGKITRTVSDY 252 Query: 257 --PALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTF 314 A D FP + I E GRY +A A ++ +K +S+ Sbjct: 253 VQEARDTRFPQTT---FIIESGRYLLAQAAVYVTEVLYRK--------------ASKGEV 295 Query: 315 MYYVNDGVYGSFNCILYDHAHVKPLLQKRPK----PDE-----------KYYSSSIWGPT 359 V+ G+ H H + R P E + +I GP Sbjct: 296 FVIVDGGM----------HHHAASTFRGRSMRSNYPMEYIPVREDSGRRELEKVTIAGPL 345 Query: 360 CDGLDRIVERCDLPEMHVGDWMLFENMGAYTVA 392 C D + + +P ++ GD + N GAY ++ Sbjct: 346 CTPEDCLGKDVHVPALYPGDLVCVLNSGAYGLS 378 >5X7M-A nrPDB Length = 453 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 91/376 (24%), Positives = 161/376 (42%), Gaps = 35/376 (9%) Query: 66 YAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAAN 125 YA K +K I + + G D AS E+ + + G P RI K V ++ Sbjct: 72 YASKAFLTKTIARWVDEEGLALDIASINELGIALAAGFPASRITAHGNNKGVEFLRALVQ 131 Query: 126 NGVQMMTFDS--EVELMK-VARAHPKAKLVL-RIA------TDDSKAVCRLSVKFGATLR 175 NGV + DS E+EL+ VA K + VL R+ T + A KFG +L Sbjct: 132 NGVGHVVLDSAQELELLDYVAAGEGKIQDVLIRVKPGIEAHTHEFIATSHEDQKFGFSLA 191 Query: 176 TSR---LLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFD-MGAEVGFSMYL 231 + N+++VG+ HVGS D E F A ++ + +E+G ++ Sbjct: 192 SGSAFEAAKAANNAENLNLVGLHCHVGSQVFDAEGFKLAAERVLGLYSQIHSELGVALPE 251 Query: 232 LDIGGGFP---GSEDVKLKFEEITGVINPALDKYFPSDSGV---RIIAEPGRYYVASAFT 285 LD+GGG+ + + L E+ + A+ K ++ G+ ++ EPGR + Sbjct: 252 LDLGGGYGIAYTAAEEPLNVAEVASDLLTAVGK-MAAELGIDAPTVLVEPGRAIAGPS-- 308 Query: 286 LAVNIIAKKIVLKEQTGSDDEDESSEQTFMYY-VNDGVYGSFNCILYDHAHVKPLLQKRP 344 + + E + D ++T Y V+ G+ + LY + ++ + Sbjct: 309 --------TVTIYEVGTTKDVHVDDDKTRRYIAVDGGMSDNIRPALYGSEYDARVVSRFA 360 Query: 345 KPDEKYYSSSIWGPTCDGLDRIVERCDLP-EMHVGDWMLFENMGAYTVAAASTFNGFQRP 403 + D S+ I G C+ D ++ P ++ GD++ GAY A +S +N F RP Sbjct: 361 EGDP--VSTRIVGSHCESGDILINDEIYPSDITSGDFLALAATGAYCYAMSSRYNAFTRP 418 Query: 404 TIYYVMSGPAWQLMQQ 419 + V +G + ++++ Sbjct: 419 AVVSVRAGSSRLMLRR 434 >1HKV-A nrPDB Length = 453 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 88/389 (22%), Positives = 147/389 (37%), Gaps = 57/389 (14%) Query: 66 YAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAAN 125 YA K + + ++ G D + E+ + PPERI K VS++ A Sbjct: 69 YAAKAFLCSEVARWISEEGLCLDVCTGGELAVALHASFPPERITLHGNNKSVSELTAAVK 128 Query: 126 NGVQMMTFDSEVELMKVARAHPKAKLV------------------LRIATDDSKAVCRLS 167 GV + DS E+ ++ +A +V + A +D K LS Sbjct: 129 AGVGHIVVDSMTEIERLDAIAGEAGIVQDVLVRLTVGVEAHTHEFISTAHEDQK--FGLS 186 Query: 168 VKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQA----ISDAR-CVFDMG 222 V GA + R + ++ +VG+ H+GS D + F A I R V + G Sbjct: 187 VASGAAMAAVRRVFATD---HLRLVGLHSHIGSQIFDVDGFELAAHRVIGLLRDVVGEFG 243 Query: 223 AEVGFSMYLLDIGGGF----------PGSEDVKLKFEEITGVINPALDKYFPSDSGVRII 272 E + +D+GGG P ++ K I + A+ P +++ Sbjct: 244 PEKTAQIATVDLGGGLGISYLPSDDPPPIAELAAKLGTIVSDESTAVGLPTP-----KLV 298 Query: 273 AEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYY-VNDGVYGSFNCILY 331 EPGR I L E D D S+ Y V+ G+ + LY Sbjct: 299 VEPGRAIAGPG----------TITLYEVGTVKDVDVSATAHRRYVSVDGGMSDNIRTALY 348 Query: 332 DHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLP-EMHVGDWMLFENMGAYT 390 + L+ + D + + G C+ D IV +P ++ GD + GAY Sbjct: 349 GAQYDVRLVSR--VSDAPPVPARLVGKHCESGDIIVRDTWVPDDIRPGDLVAVAATGAYC 406 Query: 391 VAAASTFNGFQRPTIYYVMSGPAWQLMQQ 419 + +S +N RP + V +G A ++++ Sbjct: 407 YSLSSRYNMVGRPAVVAVHAGNARLVLRR 435 >1KNW-A nrPDB Length = 425 Score = 47.8 bits (112), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 84/392 (21%), Positives = 149/392 (38%), Gaps = 60/392 (15%) Query: 48 ILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPER 107 I+++ + LK V +A K + I++ + G D S EI+ + G P+ Sbjct: 35 IIRRQIAALKQFDVVR--FAQKACSNIHILRLMREQGVKVDSVSLGEIERALAAGYNPQT 92 Query: 108 ----------IIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRI-- 155 +I ++VS+++ N G M L ++ + P ++ LR+ Sbjct: 93 HPDDIVFTADVIDQATLERVSELQIPVNAGSVDM-------LDQLGQVSPGHRVWLRVNP 145 Query: 156 ----ATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQA 211 + K G L+ + ++ +VG+ H+GSG Sbjct: 146 GFGHGHSQKTNTGGENSKHGIWYTDLPAALDVIQRHHLQLVGIHMHIGSGVDYAHLEQVC 205 Query: 212 ISDARCVFDMGAEVGFSMYLLDIGGGFP-----GSEDVKLKFEEITGVINPALDKYFPS- 265 + R V + G + + + GGG G E V E G+ N A ++ Sbjct: 206 GAMVRQVIEFGQD----LQAISAGGGLSVPYQQGEEAVDT--EHYYGLWNAAREQIARHL 259 Query: 266 DSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGS 325 V++ EPGR+ VA + L + + K Q GS + F + +YGS Sbjct: 260 GHPVKLEIEPGRFLVAQSGVLITQVRSVK-----QMGSR-HFVLVDAGFNDLMRPAMYGS 313 Query: 326 FNCILYDHAHVKPLL-QKRPKPDEKYYSSSIWGPTCDGLDRI-------VERCDLPEMHV 377 ++ H+ L R + + GP C+ D VE LPE+ Sbjct: 314 YH-------HISALAADGRSLEHAPTVETVVAGPLCESGDVFTQQEGGNVETRALPEVKA 366 Query: 378 GDWMLFENMGAYTVAAASTFNGFQRPTIYYVM 409 GD+++ + GAY + +S +N RP + V+ Sbjct: 367 GDYLVLHDTGAYGASMSSNYN--SRPLLPEVL 396 >3N29-A nrPDB Length = 418 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 71/304 (23%), Positives = 127/304 (41%), Gaps = 34/304 (11%) Query: 131 MTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKEL-NI 189 + F+S + K K L LR + S A L G R SRL + RAK+ N+ Sbjct: 136 IVFNSLAQFHKFQSKTQKNSLGLRCNVEFSLAPKELYNPCG---RYSRLGI-RAKDFENV 191 Query: 190 DVVGV-SFHVGSGCTDPETFVQAISDARCVFD--MGAEVGFSMYLLDIGGGFPGSEDVKL 246 D+ + H + C + ++A+ VF+ G +G M ++ GGG + Sbjct: 192 DLNAIEGLHFHALCEESADALEAVLK---VFEEKFGKWIG-QMKWVNFGGG----HHITK 243 Query: 247 KFEEITGVINPALDKYFPSDSGVRIIAEPGR---YYVASAFTLAVNIIA--KKIVLKEQT 301 K ++ +I AL K F GV++ EPG + + V+II K+I + + Sbjct: 244 KGYDVEKLI--ALCKNFSDKYGVQVYLEPGEAVGWQTGNLVASVVDIIENEKQIAILD-- 299 Query: 302 GSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCD 361 + E + M Y ++ +L +K E ++ + G TC Sbjct: 300 -TSSEAHMPDTIIMPYTSE--------VLNARILATRENEKISDLKENEFAYLLTGNTCL 350 Query: 362 GLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQ 421 D + E ++ +GD ++F + YT+ +TFNG + P + + Q++++F Sbjct: 351 AGDVMGEYAFDKKLKIGDKIVFLDQIHYTIVKNTTFNGIRLPNLMLLDHKNELQMIREFS 410 Query: 422 NPDF 425 D+ Sbjct: 411 YKDY 414 >3MT1-A nrPDB Length = 365 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 41/172 (23%), Positives = 66/172 (38%), Gaps = 35/172 (20%) Query: 261 KYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVND 320 + F GV+I EPG + + TL V ++ D Sbjct: 217 RAFSDRYGVQIYLEPGEASITKSTTLEVTVL----------------------------D 248 Query: 321 GVYGSFNCILYD---HAHVKPLLQKRPK----PDEKYYSSSIWGPTCDGLDRIVERCDLP 373 +Y N + D AH+ LL R P+E +S I G +C D E Sbjct: 249 TLYNGKNLAIVDSSIEAHMLDLLIYRETAKVLPNEGSHSYMICGKSCLAGDVFGEFRFAE 308 Query: 374 EMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDF 425 E+ VGD + F++ YT+ + FNG + P I + + +++F D+ Sbjct: 309 ELKVGDRISFQDAAGYTMVKKNWFNGVKMPAIAIRELDGSVRTVREFTYADY 360 >3N2O-A nrPDB Length = 648 Score = 33.1 bits (74), Expect = 0.28, Method: Compositional matrix adjust. Identities = 58/276 (21%), Positives = 106/276 (38%), Gaps = 35/276 (12%) Query: 66 YAVKCNDSKAIVKTLAATGT-------GFDCASKTEIQLVQSLGVPPERIIYANPCKQVS 118 Y +K N + +V + A+ G + SK E+ V ++ +I N K Sbjct: 102 YPIKVNQQREVVDEILASQAQLETKQLGLEAGSKPELLAVLAMAQHASSVIVCNGYKDRE 161 Query: 119 QIKYA------ANNGVQMMTFDSEVELM----KVARAHPKAKLVLRIATDDS---KAVCR 165 I+ A + ++ SE++L+ K P+ + +R+A+ + +A Sbjct: 162 YIRLALIGEKLGHKVFIVLEKMSELDLVLREAKSLGVTPRLGIRIRLASQGAGKWQASGG 221 Query: 166 LSVKFGATLRTSRLLLERAKELN-IDVVG-VSFHVGSGCTDPETFVQAISDARCVFDMGA 223 KFG + ++ R K+ N +D + V FH+GS + ++++ + Sbjct: 222 EKSKFGLSASQVLNVISRLKKENQLDTLQLVHFHLGSQMANIRDVRNGVNESARFYCELR 281 Query: 224 EVGFSMYLLDIGGGFPGSEDVKLK----------FEEITGVINPALD--KYFPSDSGVRI 271 +G ++ D+GGG D E ++N D K + V I Sbjct: 282 TLGANITYFDVGGGLAIDYDGTRSQSSNSMNYGLVEYARNIVNTVGDVCKDYKQPMPV-I 340 Query: 272 IAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDED 307 I+E GR A L N+I + E +ED Sbjct: 341 ISESGRSLTAHHAVLISNVIGTETYKPETVTEPEED 376 >3NZQ-A nrPDB Length = 666 Score = 32.3 bits (72), Expect = 0.42, Method: Compositional matrix adjust. Identities = 52/260 (20%), Positives = 99/260 (38%), Gaps = 38/260 (14%) Query: 66 YAVKCNDSKAIVKTLAATGT--GFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYA 123 Y +K N + ++++L +G G + SK E+ V + +I N K I+ A Sbjct: 124 YPIKVNQHRRVIESLIHSGEPLGLEAGSKAELMAVLAHAGMTRSVIVCNGYKDREYIRLA 183 Query: 124 -------------ANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDS---KAVCRLS 167 ++ E E + V P+ + R+A+ S ++ Sbjct: 184 LIGEKMGHKVYLVIEKMSEIAIVLDEAERLNVV---PRLGVRARLASQGSGKWQSSGGEK 240 Query: 168 VKFGATLRTSRLLLERAKEL-NIDVVGV-SFHVGSGCTDPETFVQAISDARCVFDMGAEV 225 KFG L+E +E +D + + FH+GS + + ++ + ++ Sbjct: 241 SKFGLAATQVLQLVETLREAGRLDSLQLLHFHLGSQMANIRDIATGVRESARFYVELHKL 300 Query: 226 GFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPS----------DSGV---RII 272 G ++ D+GGG D + + +N L++Y + ++G+ +I Sbjct: 301 GVNIQCFDVGGGL--GVDYEGTRSQSDCSVNYGLNEYANNIIWAIGDACEENGLPHPTVI 358 Query: 273 AEPGRYYVASAFTLAVNIIA 292 E GR A L NII Sbjct: 359 TESGRAVTAHHTVLVSNIIG 378 >3KVS-A nrPDB Length = 162 Score = 32.3 bits (72), Expect = 0.48, Method: Compositional matrix adjust. Identities = 24/86 (27%), Positives = 35/86 (40%), Gaps = 3/86 (3%) Query: 169 KFGATLRTSRLLLERAKEL---NIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEV 225 + A+L +R L A+ L V F S P+ A+ A+C D+G + Sbjct: 33 RAAASLEAARSLTSNAQRLINGAAQAVYSKFPYTSQMPGPQYASSAVGKAKCARDIGYYL 92 Query: 226 GFSMYLLDIGGGFPGSEDVKLKFEEI 251 Y L +GG P E + EEI Sbjct: 93 RMVTYCLVVGGTGPMDEYLIAGLEEI 118 >2V1C-A nrPDB Length = 220 Score = 31.6 bits (70), Expect = 0.85, Method: Compositional matrix adjust. Identities = 33/140 (23%), Positives = 55/140 (39%), Gaps = 21/140 (15%) Query: 307 DESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRI 366 + S E +Y+V GV N + D H+KPLL P+ + G T +G Sbjct: 95 ERSGEYRGLYHVLHGVLSPMNGVGPDKLHIKPLL---PRVGQGMEVILATGTTVEG---- 147 Query: 367 VERCDLPEMHVGDWMLFENMG------AYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQF 420 D +++ L E +G AY V + T+ ++G Q + + Sbjct: 148 ----DATALYL--QRLLEPLGAAISRIAYGVPVGGSLEYTDEVTLGRALTG--RQTVSKP 199 Query: 421 QNPDFPPEVEEQDASTLPVS 440 Q P P + + D + +P S Sbjct: 200 QPPQRPGDEDGADGAAVPAS 219 >5V5P-C nrPDB Length = 528 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 14/51 (27%), Positives = 28/51 (54%) Query: 277 RYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFN 327 R+ S + ++N+I K ++E+ + E++ + F + V DG G+FN Sbjct: 477 RHENESVYKASLNLIEKYFSVEEEEDQNVVPETTSEGFAFQVQDGAPGTFN 527 >4ATE-A nrPDB Length = 266 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 35/149 (23%), Positives = 60/149 (40%), Gaps = 30/149 (20%) Query: 249 EEITGVINPALDKYFPSDSGV-RIIAEPGRYYVA----------SAFTLAVNIIAKKIVL 297 +E + V +P D + + + V + A+PG YY A S+F V ++ V+ Sbjct: 73 KEPSSVQDPFKDIWVDAAAAVSKTKAQPGYYYEARFKASSLSMTSSFWFRVGQFSEIDVI 132 Query: 298 KEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPD---EKYYSSS 354 + E+ + + Y+VN YG HA ++PL + P + +Y+ Sbjct: 133 EHIGNPSKENRQDDLPYQYHVNTHYYGK-------HAGLQPLGTEYKMPGRGRDNFYTYG 185 Query: 355 IWGPTCDGL---------DRIVERCDLPE 374 W + + L RIV R L E Sbjct: 186 FWWKSPNELLFYFNGKQVMRIVPRVPLDE 214 >4HDR-B nrPDB Length = 350 Score = 28.5 bits (62), Expect = 6.8, Method: Compositional matrix adjust. Identities = 29/106 (27%), Positives = 46/106 (43%), Gaps = 21/106 (19%) Query: 118 SQIKYAANNGVQMMTFDSEVEL-------------MKVARAHPKAKLVL---RIATD--D 159 S I AA+NGV M T ++ ++V AH +A+L++ +A D Sbjct: 59 SIIIMAADNGVAMATDQQQMTTAARLTGFCQGQAPIQVFAAHVQARLIMVDIGVAADLPH 118 Query: 160 SKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSF---HVGSGC 202 S AVCR + +G+ T + R + + VGV + GC Sbjct: 119 SPAVCRKKLAYGSRNSTEGPAMTRQQAIQAIEVGVRIAQAEIARGC 164 >3IHL-A nrPDB Length = 282 Score = 28.1 bits (61), Expect = 7.4, Method: Compositional matrix adjust. Identities = 15/61 (24%), Positives = 31/61 (50%), Gaps = 4/61 (6%) Query: 70 CNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQ 129 CN ++V L+ATG ++ ++ ++ LG+ P+ I+ C+ + I+ A + Sbjct: 176 CNIHVSLVPQLSATGEQKTKPTQNSVRALRGLGLSPDLIV----CRSSTPIEMAVKEKIS 231 Query: 130 M 130 M Sbjct: 232 M 232 >1SMS-A nrPDB Length = 345 Score = 28.1 bits (61), Expect = 9.2, Method: Compositional matrix adjust. Identities = 12/42 (28%), Positives = 24/42 (57%), Gaps = 7/42 (16%) Query: 321 GVYGSFNCILYDHAHVKP-------LLQKRPKPDEKYYSSSI 355 G Y F+C+L+ H KP ++ + + +++YYS+S+ Sbjct: 221 GAYTDFSCLLFAHLRTKPNPKIIEKIITEAVEIEKEYYSNSL 262 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1D7K-A nrPDB 635 0.0 7ODC-A nrPDB 614 e-176 1NJJ-A nrPDB 549 e-157 4ZGZ-A nrPDB 471 e-133 4AIB-A nrPDB 400 e-112 2NV9-A nrPDB 382 e-106 2P3E-A nrPDB 381 e-106 5GJN-A nrPDB 365 e-101 2QGH-A nrPDB 358 3e-99 3N2B-A nrPDB 348 2e-96 4XG1-A nrPDB 344 7e-95 2PLJ-A nrPDB 337 5e-93 2YXX-A nrPDB 337 6e-93 3VAB-A nrPDB 324 5e-89 1TWI-A nrPDB 324 5e-89 1HKV-A nrPDB 305 2e-83 1KNW-A nrPDB 300 1e-81 5X7M-A nrPDB 294 6e-80 2J66-A nrPDB 284 5e-77 3N29-A nrPDB 213 2e-55 3MT1-A nrPDB 163 1e-40 Sequences not found previously or not previously below threshold: 3NZP-A nrPDB 94 1e-19 3N2O-A nrPDB 90 2e-18 3NZQ-A nrPDB 89 4e-18 3KS6-A nrPDB 36 0.044 6NXI-A nrPDB 35 0.074 4DEF-A nrPDB 32 0.43 3MBD-A nrPDB 32 0.60 5LDA-A nrPDB 30 1.9 6NBP-A nrPDB 29 3.4 5KLK-A nrPDB 29 3.9 2MA1-A nrPDB 29 5.0 5BSW-A nrPDB 29 6.9 5DA8-A nrPDB 28 7.3 >1D7K-A nrPDB Length = 421 Score = 635 bits (1638), Expect = 0.0, Method: Composition-based stats. Identities = 420/421 (99%), Positives = 421/421 (100%) Query: 7 EEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFY 66 EEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFY Sbjct: 1 EEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFY 60 Query: 67 AVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANN 126 AVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANN Sbjct: 61 AVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANN 120 Query: 127 GVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKE 186 GVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKE Sbjct: 121 GVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKE 180 Query: 187 LNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKL 246 LNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKL Sbjct: 181 LNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKL 240 Query: 247 KFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDE 306 KFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDE Sbjct: 241 KFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDE 300 Query: 307 DESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRI 366 DESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDE+YYSSSIWGPTCDGLDRI Sbjct: 301 DESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDERYYSSSIWGPTCDGLDRI 360 Query: 367 VERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDFP 426 VERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDFP Sbjct: 361 VERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDFP 420 Query: 427 P 427 P Sbjct: 421 P 421 >7ODC-A nrPDB Length = 424 Score = 614 bits (1584), Expect = e-176, Method: Composition-based stats. Identities = 387/422 (91%), Positives = 403/422 (95%) Query: 1 MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALP 60 M++F +EFDCH LDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALP Sbjct: 1 MSSFTKDEFDCHILDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALP 60 Query: 61 RVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQI 120 RVTPFYAVKCNDS+AIV TLAA GTGFDCASKTEIQLVQ LGVP ER+IYANPCKQVSQI Sbjct: 61 RVTPFYAVKCNDSRAIVSTLAAIGTGFDCASKTEIQLVQGLGVPAERVIYANPCKQVSQI 120 Query: 121 KYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLL 180 KYAA+NGVQMMTFDSE+ELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATL+TSRLL Sbjct: 121 KYAASNGVQMMTFDSEIELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLKTSRLL 180 Query: 181 LERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPG 240 LERAKELNIDV+GVSFHVGSGCTDP+TFVQA+SDARCVFDM EVGFSM+LLDIGGGFPG Sbjct: 181 LERAKELNIDVIGVSFHVGSGCTDPDTFVQAVSDARCVFDMATEVGFSMHLLDIGGGFPG 240 Query: 241 SEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQ 300 SED KLKFEEIT VINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKK V KEQ Sbjct: 241 SEDTKLKFEEITSVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKTVWKEQ 300 Query: 301 TGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTC 360 GSDDEDES+EQTFMYYVNDGVYGSFNCILYDHAHVK LLQKRPKPDEKYYSSSIWGPTC Sbjct: 301 PGSDDEDESNEQTFMYYVNDGVYGSFNCILYDHAHVKALLQKRPKPDEKYYSSSIWGPTC 360 Query: 361 DGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQF 420 DGLDRIVERC+LPEMHVGDWMLFENMGAYTVAAASTFNGFQRP IYYVMS P WQLM+Q Sbjct: 361 DGLDRIVERCNLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPNIYYVMSRPMWQLMKQI 420 Query: 421 QN 422 Q+ Sbjct: 421 QS 422 >1NJJ-A nrPDB Length = 425 Score = 549 bits (1415), Expect = e-157, Method: Composition-based stats. Identities = 275/422 (65%), Positives = 335/422 (79%), Gaps = 2/422 (0%) Query: 1 MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALP 60 M+ N++ C FL EGF +D L +KI+ +++ D+ D F+VADLGDI++KH W K LP Sbjct: 3 MDIVVNDDLSCRFL-EGFNTRDALCKKIS-MNTCDEGDPFFVADLGDIVRKHETWKKCLP 60 Query: 61 RVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQI 120 RVTPFYAVKCND ++ TLAA GTGFDCAS TEIQ V+ +GVPPE+IIYANPCKQ+S I Sbjct: 61 RVTPFYAVKCNDDWRVLGTLAALGTGFDCASNTEIQRVRGIGVPPEKIIYANPCKQISHI 120 Query: 121 KYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLL 180 +YA ++GV +MTFD EL KVA+ HPKAK+VLRI+TDDS A CRLSVKFGA + R + Sbjct: 121 RYARDSGVDVMTFDCVDELEKVAKTHPKAKMVLRISTDDSLARCRLSVKFGAKVEDCRFI 180 Query: 181 LERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPG 240 LE+AK+LNIDV GVSFHVGSG TD TF QAISD+R VFDMG E+GF+M++LDIGGGFPG Sbjct: 181 LEQAKKLNIDVTGVSFHVGSGSTDASTFAQAISDSRFVFDMGTELGFNMHILDIGGGFPG 240 Query: 241 SEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQ 300 + D LKFEEI GVIN AL+K+FP D + I+AEPGRYYVASAFTLAVN+IAKK+ Q Sbjct: 241 TRDAPLKFEEIAGVINNALEKHFPPDLKLTIVAEPGRYYVASAFTLAVNVIAKKVTPGVQ 300 Query: 301 TGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTC 360 T ES+ Q+FMYYVNDGVYGSFNCILYDHA V+PL Q+ P P+EK Y SS+WGPTC Sbjct: 301 TDVGAHAESNAQSFMYYVNDGVYGSFNCILYDHAVVRPLPQREPIPNEKLYPSSVWGPTC 360 Query: 361 DGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQF 420 DGLD+IVER LPEM VG+W+LFE+MGAYTV S+FNGFQ PTIYYV+SG ++++ Sbjct: 361 DGLDQIVERYYLPEMQVGEWLLFEDMGAYTVVGTSSFNGFQSPTIYYVVSGLPDHVVREL 420 Query: 421 QN 422 ++ Sbjct: 421 KS 422 >4ZGZ-A nrPDB Length = 438 Score = 471 bits (1212), Expect = e-133, Method: Composition-based stats. Identities = 221/412 (53%), Positives = 292/412 (70%), Gaps = 5/412 (1%) Query: 8 EFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYA 67 + LDEG +++D + E + + K+AF+V DLG I+KKH +W + ++ PFY Sbjct: 10 NYSVGLLDEGTDLGNVIDNYVYEHTLTG-KNAFFVGDLGKIVKKHSQWQNVVAQIKPFYT 68 Query: 68 VKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNG 127 VKCN + A+++ LAA GTGF C+SK E+ LVQ LGVPPE IIY +PCKQVSQIKYAA G Sbjct: 69 VKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAKVG 128 Query: 128 VQMMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKEL 187 V ++T D+E+EL K+AR HP AK++L IAT+D+ ++KFG TL+ R LLE AKEL Sbjct: 129 VNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHLLECAKEL 188 Query: 188 NIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLK 247 ++ ++GV FHV S C + + +V A+SDARCVFDM E+GF+M +LDIGGGF G+E + Sbjct: 189 DVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGTE---FQ 245 Query: 248 FEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDED 307 EE+ VI+P LD YFP SGV+II+EPG YYV+SAFTLAVNIIAKK+V ++ S E Sbjct: 246 LEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEK 305 Query: 308 E-SSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRI 366 S E FMYY+NDGVYGSF L + + P + K+ K DE ++SS+WGP+CD LD+I Sbjct: 306 TGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQI 365 Query: 367 VERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQ 418 VE C LPE++VGDW++F+NMGA + S FN FQRP IYY+MS W MQ Sbjct: 366 VESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQ 417 >4AIB-A nrPDB Length = 395 Score = 400 bits (1028), Expect = e-112, Method: Composition-based stats. Identities = 133/397 (33%), Positives = 211/397 (53%), Gaps = 21/397 (5%) Query: 26 QKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGT 85 I++ + F++ D + K RW K +P V P +AVKCN +VK L G Sbjct: 14 NLISQFEPENQPLGFWIFDTEGVEKAVERWKKNMPTVRPCFAVKCNPEPHLVKLLGELGC 73 Query: 86 GFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARA 145 GFDCAS EI+ V LG PE I Y+ K +Q+ A++ G+ DS E+ K+A+ Sbjct: 74 GFDCASLNEIKEVLDLGFNPEDITYSQTFKPYNQLIEASHLGINHTIVDSIDEVQKIAKY 133 Query: 146 HPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDP 205 PK +++RI +D+ A KFG ++L+ K+ +++ GV FHVGS + Sbjct: 134 APKMGIMIRIMENDTSAGHVFGEKFGLHDDEVEIVLKEIKDKGLNLDGVHFHVGSDSHNS 193 Query: 206 ETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKY-FP 264 E F +A++ AR + + G YL+DIGGGF FEE I + + FP Sbjct: 194 EVFTKALTKARNTVTLAEQFGMKPYLIDIGGGFSQVA----PFEEFAATIEKTIKELEFP 249 Query: 265 SDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYG 324 + R IAEPGRY ++AF L ++ K++ + ++ ++ Y DG++G Sbjct: 250 ERT--RFIAEPGRYMASNAFHLVSSLHGKRVRI----------QNGKKQIEYTSGDGLHG 297 Query: 325 SFN-CILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVG-DWML 382 SF CI ++ + ++ + K Y S I+GP+C+G D++ + +LPEM G DW+L Sbjct: 298 SFGCCIWFEKQKSCECITQKVNENTKMYESIIYGPSCNGSDKVATQ-ELPEMEPGKDWLL 356 Query: 383 FENMGAYTVAAASTFNGF-QRPTIYYVMSGPAWQLMQ 418 F NMGAYT++ A+ FNGF +R + Y + + +++Q Sbjct: 357 FPNMGAYTISMATNFNGFEERNHVIYTLPLKSTKIIQ 393 >2NV9-A nrPDB Length = 372 Score = 382 bits (982), Expect = e-106, Method: Composition-based stats. Identities = 142/373 (38%), Positives = 211/373 (56%), Gaps = 15/373 (4%) Query: 36 DKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEI 95 +FYV+ + +W PRVTP YAVKCN+ + ++KT+ FDCAS +EI Sbjct: 15 QTKSFYVSSPKIVEDLIDQWTILFPRVTPHYAVKCNNDEVLLKTMCDKNVNFDCASSSEI 74 Query: 96 QLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRI 155 + V +GV P RII+A+ K + + +A + GV + TFDS EL K+ HP K++LRI Sbjct: 75 KKVIQIGVSPSRIIFAHTMKTIDDLIFAKDQGVDIATFDSSFELDKIHTYHPNCKMILRI 134 Query: 156 ATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDA 215 DD A +L KFGA R LLE AK+L+I+V+G+SFHVGSG +PE + +AI + Sbjct: 135 RCDDPNAAVQLGNKFGANEDEIRHLLEYAKQLDIEVIGISFHVGSGSRNPEAYYRAIKSS 194 Query: 216 RCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEP 275 + F+ VG Y+LDIGGG D ++ IN A+ +FP D+ V I+AEP Sbjct: 195 KEAFNEAISVGHKPYILDIGGGLHADIDEGELSTYMSDYINDAIKDFFPEDT-VTIVAEP 253 Query: 276 GRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAH 335 GR++ LA +I K++ + + Y+ N+ YG F+ ++++ + Sbjct: 254 GRFFAEHYSVLATQVIGKRV--------------RDGLYEYFFNESTYGGFSNVIFEKSV 299 Query: 336 VKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAAS 395 P L + DE+Y S ++G TCDG+D I LPE+H+GDW+ F + GAYT + Sbjct: 300 PTPQLLRDVPDDEEYVPSVLYGCTCDGVDVINHNVALPELHIGDWVYFPSWGAYTNVLTT 359 Query: 396 TFNGFQRPTIYYV 408 +FNGF +YY+ Sbjct: 360 SFNGFGEYDVYYI 372 >2P3E-A nrPDB Length = 420 Score = 381 bits (977), Expect = e-106, Method: Composition-based stats. Identities = 105/403 (26%), Positives = 179/403 (44%), Gaps = 37/403 (9%) Query: 37 KDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQ 96 YV I ++ + KA P YAVK N + +VK L G G D S E+ Sbjct: 33 GTPLYVYSSNFIKERFEAYRKAFPDALICYAVKANFNPHLVKLLGELGAGADIVSGGELY 92 Query: 97 LVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHP----KAKLV 152 L + G+PPERI+YA K ++ A ++ + M +S EL + KA++ Sbjct: 93 LAKKAGIPPERIVYAGVGKTEKELTDAVDSEILMFNVESRQELDVLNEIAGKLGKKARIA 152 Query: 153 LRIATD-DSKAVCRLSV-----KFGATLRTSRLLLERAKEL-NIDVVGVSFHVGSGCTDP 205 +R+ D D K ++ KFG +R ++ E A +L N+++VG+ H+GS D Sbjct: 153 IRVNPDVDPKTHPYIATGMQKSKFGVDIREAQKEYEYASKLENLEIVGIHCHIGSQILDI 212 Query: 206 ETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPS 265 + +A+ +++ + GF + LDIGGG +K K E+ D Sbjct: 213 SPYREAVEKVVSLYESLTQKGFDIKYLDIGGGLG----IKYKPEDKEPAPQDLADLLKDL 268 Query: 266 DSGV--RIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVY 323 V +II EPGR + +A L + K D+ S+ V+ G+ Sbjct: 269 LENVKAKIILEPGRSIMGNAGILITQVQFLK------------DKGSKH--FIIVDAGMN 314 Query: 324 GSFNCILYDH-AHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWML 382 +Y+ H+ P+ K + K + I GP C+ D + ++ E+ G+++ Sbjct: 315 DLIRPSIYNAYHHIIPVETK----ERKKVVADIVGPICETGDFLALDREIEEVQRGEYLA 370 Query: 383 FENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDF 425 + GAY A +S +N R V +G + +L+++ +N D+ Sbjct: 371 VLSAGAYGFAMSSHYNMRPRAAEVLVENG-SVKLIRKRENYDY 412 >5GJN-A nrPDB Length = 393 Score = 365 bits (936), Expect = e-101, Method: Composition-based stats. Identities = 127/374 (33%), Positives = 200/374 (53%), Gaps = 24/374 (6%) Query: 37 KDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQ 96 F VA L + + + + LPR FYA+K N + I+ LA G+ FD AS E++ Sbjct: 19 PTPFLVASLDKVEENYQFMRRHLPRAGVFYAMKANPTPEILSLLAGLGSHFDVASAGEME 78 Query: 97 LVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLRIA 156 ++ LGV ++IYANP K +K AA+ V+ TFD E+ K+A+A P A +++RIA Sbjct: 79 ILHELGVDGSQMIYANPVKDARGLKAAADYNVRRFTFDDPSEIDKMAKAVPGADVLVRIA 138 Query: 157 TDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDAR 216 ++KA+ L+ KFGA + + LL+ A++ + +G+ FHVGS + +A+ AR Sbjct: 139 VRNNKALVDLNTKFGAPVEEALDLLKAAQDAGLHAMGICFHVGSQSLSTAAYEEALLVAR 198 Query: 217 CVFDMGAEVGFSMYLLDIGGGFPGS--EDVKLKFEEITGVINPALDKYFPSDSGVRIIAE 274 +FD E+G + LDIGGGFP + + + + IN +D+ FP + + E Sbjct: 199 RLFDEAEEMGMHLTDLDIGGGFPVPDAKGLNVDLAAMMEAINKQIDRLFPDTA---VWTE 255 Query: 275 PGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHA 334 PGRY +A L ++I K ++ Y +++G+YG F+ I+YDH Sbjct: 256 PGRYMCGTAVNLVTSVIGTKTRGEQP--------------WYILDEGIYGCFSGIMYDHW 301 Query: 335 HVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAA 394 L K ++K S+ GP+CDG+D + PE+ +GD +L MG+YT +A Sbjct: 302 TYP--LHCFGKGNKK--PSTFGGPSCDGIDVLYRDFMAPELKIGDKVLVTEMGSYTSVSA 357 Query: 395 STFNGFQR-PTIYY 407 + FNGF PTI + Sbjct: 358 TRFNGFYLAPTIIF 371 >2QGH-A nrPDB Length = 425 Score = 358 bits (918), Expect = 3e-99, Method: Composition-based stats. Identities = 98/412 (23%), Positives = 172/412 (41%), Gaps = 39/412 (9%) Query: 37 KDAFYVADLGDILKKHLRWLKALPRVT--PFYAVKCNDSKAIVKTLAATGTGFDCASKTE 94 K FY+ D I + L + +A YA+K N + +I+ LA +G DC S E Sbjct: 32 KTPFYLYDFDKIKQAFLNYKEAFKGRKSLICYALKANSNLSILSLLAHLESGADCVSIGE 91 Query: 95 IQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHP----KAK 150 IQ G+ P RI+++ K +I+ A + + +S +EL + KA+ Sbjct: 92 IQRALKAGIKPYRIVFSGVGKSAFEIEQALKLNILFLNVESFMELKTIETIAQSLGIKAR 151 Query: 151 LVLRIATD-DSKAVCRLSV-----KFGATLRTS-RLLLERAKELNIDVVGVSFHVGSGCT 203 + +RI + D+K +S KFG + + + L K ++ V V FH+GS Sbjct: 152 ISIRINPNIDAKTHPYISTGLKENKFGVGEKEALEMFLWAKKSAFLEPVSVHFHIGSQLL 211 Query: 204 DPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSE--DVKLKFEEITGVINPALDK 261 D E ++A + +G + D+GGG S + +K + I AL Sbjct: 212 DLEPIIEASQKVAKIAKSLIALGIDLRFFDVGGGIGVSYENEETIKLYDYAQGILNAL-- 269 Query: 262 YFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDG 321 + II EPGR VA + L ++ +K ++ V+ G Sbjct: 270 ---QGLDLTIICEPGRSIVAESGELITQVLYEK--------------KAQNKRFVIVDAG 312 Query: 322 VYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWM 381 + LY H ++ P + + GP C+ D ++ LPE+ GD + Sbjct: 313 MNDFLRPSLYHAKHAIRVIT--PSKGREISPCDVVGPVCESSDTFLKDAHLPELEPGDKI 370 Query: 382 LFENMGAYTVAAASTFNGFQRPTIYYV-MSGPAWQLMQQFQNPDFPPEVEEQ 432 E +GAY + AS +N RP + + + +++++ + + +EE+ Sbjct: 371 AIEKVGAYGSSMASQYN--SRPKLLELALEDHKIRVIRKREALEDLWRLEEE 420 >3N2B-A nrPDB Length = 441 Score = 348 bits (893), Expect = 2e-96, Method: Composition-based stats. Identities = 103/437 (23%), Positives = 175/437 (40%), Gaps = 50/437 (11%) Query: 1 MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALP 60 M+ F +E D E D+ +Q YV + + + K++ Sbjct: 25 MDYFNYQE-DGQLWAEQVPLADLANQY---------GTPLYVYSRATLERHWHAFDKSVG 74 Query: 61 RV--TPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVS 118 YAVK N + ++ TLA G+GFD S E++ V + G P +++++ K + Sbjct: 75 DYPHLICYAVKANSNLGVLNTLARLGSGFDIVSVGELERVLAAGGDPSKVVFSGVGKTEA 134 Query: 119 QIKYAANNGVQMMTFDSEVELMKVARAHP----KAKLVLRIATD-DSKAVCRLSV----- 168 ++K A ++ +SE EL ++ + KA + LRI D D+K +S Sbjct: 135 EMKRALQLKIKCFNVESEPELQRLNKVAGELGVKAPISLRINPDVDAKTHPYISTGLRDN 194 Query: 169 KFGATLRTSRLLLERAKEL-NIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGF 227 KFG T + + A L N+DV G+ H+GS T F+ A + D G Sbjct: 195 KFGITFDRAAQVYRLAHSLPNLDVHGIDCHIGSQLTALAPFIDATDRLLALIDSLKAEGI 254 Query: 228 SMYLLDIGGGFPGSE--DVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFT 285 + LD+GGG ++ + E + L+++ + +I EPGR A+A Sbjct: 255 HIRHLDVGGGLGVVYRDELPPQPSEYAKALLDRLERH----RDLELIFEPGRAIAANAGV 310 Query: 286 LAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQKRPK 345 L + K E ++ + LY + RP+ Sbjct: 311 LVTKVEFLKHT--------------EHKNFAIIDAAMNDLIRPALYQAWQDI--IPLRPR 354 Query: 346 PDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTI 405 E + + GP C+ D + + DL + GD + + GAY +S +N RP + Sbjct: 355 QGEA-QTYDLVGPVCETSDFLGKDRDLV-LQEGDLLAVRSSGAYGFTMSSNYN--TRPRV 410 Query: 406 YYVM-SGPAWQLMQQFQ 421 VM G L++Q + Sbjct: 411 AEVMVDGNKTYLVRQRE 427 >4XG1-A nrPDB Length = 427 Score = 344 bits (881), Expect = 7e-95, Method: Composition-based stats. Identities = 97/440 (22%), Positives = 182/440 (41%), Gaps = 52/440 (11%) Query: 1 MNNFGNEEFDCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALP 60 M++F N + D EG + ++ + Y+ +++H + + Sbjct: 1 MDHF-NYQNDGRLFVEGLPVEQVVKK---------TGTPAYIYSRA-TIERHWQAFDSAA 49 Query: 61 RVTP---FYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQV 117 P YAVK N + A++ +A G+GFD S E+ V G P++I+++ K Sbjct: 50 GKHPHLICYAVKANSNLAVLNLMARMGSGFDIVSVGELMRVIQAGGDPKKIVFSGVGKTE 109 Query: 118 SQIKYAANNGVQMMTFDSEVELMKVARAHP----KAKLVLRIATD-DSKAVCRLSV---- 168 +I A + +S EL ++ KA + +RI + D+ +S Sbjct: 110 IEISAALQANIMCFNVESISELYRINSVAKALNVKAPISIRINPNIDAGTHPYISTGLKE 169 Query: 169 -KFGATLRTSRLLLERAKELN-IDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVG 226 KFG + + + + A +L +++ GV H+GS T+ F++A+ + D+ AE G Sbjct: 170 NKFGIEIEQALDVYKIASDLEFLEIKGVDCHIGSQLTEIAPFIEALDKLLILIDLLAEKG 229 Query: 227 FSMYLLDIGGGFPGSEDVKLKF---EEITGVINPALDKYFPSDSGVRIIAEPGRYYVASA 283 ++ LD+GGG D + E +T +IN + +++I EPGR +A+A Sbjct: 230 ITISHLDLGGGLGVPYDDETPPEPAEYMTAIINRMAGR------SLKLIFEPGRAIMANA 283 Query: 284 FTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHA-HVKPLL-Q 341 L + K+ ++ V+ + LY ++ PL Sbjct: 284 GVLVTKVEFLKL--------------NDYKNFAIVDAAMNDLIRPALYSAWQNIIPLNTD 329 Query: 342 KRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQ 401 + D S I GP C+ D + + L + GD+++ + GAY +S +N Sbjct: 330 YQDGQDRPVRSYDIVGPICETGDFLGKERQL-ALAEGDYLVIRSTGAYGSTMSSNYNSRC 388 Query: 402 RPTIYYVMSGPAWQLMQQFQ 421 R V G ++++ + Sbjct: 389 RAAEILVD-GEKAFIVRERE 407 >2PLJ-A nrPDB Length = 419 Score = 337 bits (865), Expect = 5e-93, Method: Composition-based stats. Identities = 125/381 (32%), Positives = 193/381 (50%), Gaps = 22/381 (5%) Query: 30 EVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDC 89 E S + D I +++ ALP VT YA+K +V+TL A G FD Sbjct: 47 EASVEQFGAPLLLLDCDVIRQQYRALKNALPNVTLHYALKPLPHPVVVRTLLAEGASFDL 106 Query: 90 ASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKA 149 A+ E++LV S GVP + I+ +P K+ + I+ A G + D+ EL K Sbjct: 107 ATTGEVELVASEGVPADLTIHTHPIKRDADIRDALAYGCNVFVVDNLNELEKFKAYRDDV 166 Query: 150 KLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFV 209 +L++R++ +S+A LS KFG + + +++E AKE NI + G+SFHVGS T+P +V Sbjct: 167 ELLVRLSFRNSEAFADLSKKFGCSPEQALVIIETAKEWNIRIKGLSFHVGSQTTNPNKYV 226 Query: 210 QAISDARCVFDMGAEVGF-SMYLLDIGGGFPGSEDVK-LKFEEITGVINPALDKYFPSDS 267 +AI R V + E G ++ LDIGGGFP + + + ++ IN AL Sbjct: 227 EAIHTCRHVMEQVVERGLPALSTLDIGGGFPVNYTQQVMPIDQFCAPINEALSLL---PE 283 Query: 268 GVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFN 327 V ++AEPGR+ A A T +++ + E YY++DG+YGSF+ Sbjct: 284 TVHVLAEPGRFICAPAVTSVASVMGQA--------------EREGQIWYYLDDGIYGSFS 329 Query: 328 CILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMG 387 +++D A K + S + GPTCD +D I E LP+++ GD ++ MG Sbjct: 330 GLMFDDA---RYPLTTIKQGGELIPSVLSGPTCDSVDVIAENILLPKLNNGDLVIGRTMG 386 Query: 388 AYTVAAASTFNGFQRPTIYYV 408 AYT A A+ FN F+R + Sbjct: 387 AYTSATATDFNFFKRAQTIAL 407 >2YXX-A nrPDB Length = 386 Score = 337 bits (864), Expect = 6e-93, Method: Composition-based stats. Identities = 98/396 (24%), Positives = 165/396 (41%), Gaps = 43/396 (10%) Query: 37 KDAFYVADLGDILKKHLRWLKAL---PRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKT 93 YV + L+K R +K + + P +AVK N++ ++K L G G D +K Sbjct: 12 GTPTYVY-FEETLRKRSRLVKEVFEGVNLLPTFAVKANNNPVLLKILREEGFGMDVVTKG 70 Query: 94 EIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKA-KLV 152 E+ + GVP +++ K Q+++ V+++ DS E+ +P+ + Sbjct: 71 ELLAAKLAGVPSHTVVWNGNGKSRDQMEHFLREDVRIVNVDSFEEMEIWRELNPEGVEYF 130 Query: 153 LRIATD-DSKAVCRLSV-----KFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPE 206 +R+ + D+K +S KFG L +ER + +NI G+ H+GS T E Sbjct: 131 IRVNPEVDAKTHPHISTGLKKHKFGIPLEDLDSFMERFRSMNIR--GLHVHIGSQITRVE 188 Query: 207 TFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSE-DVKLKFEEITGVINPALDKYFPS 265 FV+A S V GF ++IGGG+ + +L + P L ++ Sbjct: 189 PFVEAFSK---VVRASERYGFE--EINIGGGWGINYSGEELDLSSYREKVVPDLKRFK-- 241 Query: 266 DSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGS 325 R+I E GRY VA + L + ++ K V+ G+ Sbjct: 242 ----RVIVEIGRYIVAPSGYLLLRVVLVK--------------RRHNKAFVVVDGGMNVL 283 Query: 326 FNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFEN 385 LY H +L K+ K + + GP C+ D I +LPE+ GD + EN Sbjct: 284 IRPALYSAYHRIFVLGKQGKEMR----ADVVGPLCESGDVIAYDRELPEVEPGDIIAVEN 339 Query: 386 MGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQ 421 GAY ++ +N RP V L+++ + Sbjct: 340 AGAYGYTMSNNYNSTTRPAEVLVRENGRISLIRRRE 375 >3VAB-A nrPDB Length = 443 Score = 324 bits (831), Expect = 5e-89, Method: Composition-based stats. Identities = 94/402 (23%), Positives = 157/402 (39%), Gaps = 32/402 (7%) Query: 37 KDAFYVADLGDILKKHLRWLKALPRV--TPFYAVKCNDSKAIVKTLAATGTGFDCASKTE 94 FYV I + + A + YA+K N ++A++ LA G G D S+ E Sbjct: 48 GTPFYVYSRATIERHFRVFHDAFADMDTLVTYALKANSNQAVLTALAKLGAGADTVSQGE 107 Query: 95 IQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVAR---AHPK-AK 150 I+ + G+P RI+++ K ++ +A G+ +SE EL ++ A K A Sbjct: 108 IRRALAAGIPANRIVFSGVGKTPREMDFALEAGIYCFNVESEPELEILSARAVAAGKVAP 167 Query: 151 LVLRIATD-DSKAVCRLSV-----KFGATLRTSRLLLERAKEL-NIDVVGVSFHVGSGCT 203 + LRI D D+K ++S KFG +R RA L ++VVG+ H+GS Sbjct: 168 VSLRINPDVDAKTHAKISTGKSENKFGIPRDKARAAYARAASLPGLNVVGIDMHIGSQII 227 Query: 204 DPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYF 263 D E F A + + G ++ +D+GGG G V + Sbjct: 228 DLEPFDNAFALMAELVKELQADGHNIRHVDVGGGL-GIPYRTPNTPPPPPVAYAQIVAKH 286 Query: 264 PSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVY 323 G++ + EPGR V +A L +I K + V+ + Sbjct: 287 IKPLGLKTVFEPGRLIVGNAGLLVTEVIFVK--------------EGDAKNFVIVDAAMN 332 Query: 324 GSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLF 383 LYD H + P + + GP C+ D + ++ + GD + Sbjct: 333 DLIRPTLYDAFHDIRPVI-MPNDNAPRIRADFVGPVCETGDYLGLDREVAKPAPGDLIAI 391 Query: 384 ENMGAYTVAAASTFNGFQRPTIYYVMSGPAW-QLMQQFQNPD 424 GAY +ST+N R I V+ +++ + + Sbjct: 392 CTTGAYGAVLSSTYN--SRLLIPEVLGDGERYHVVRPRRTYE 431 >1TWI-A nrPDB Length = 434 Score = 324 bits (830), Expect = 5e-89, Method: Composition-based stats. Identities = 97/442 (21%), Positives = 178/442 (40%), Gaps = 60/442 (13%) Query: 10 DCHFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPR-------- 61 D F +G+ A ++ ++ YV I + R+++A R Sbjct: 11 DGRFFIDGYDAIELAEKF---------GTPLYVMSEEQIKINYNRYIEAFKRWEEETGKE 61 Query: 62 VTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIK 121 YA K N + AI + LA G G D S E+ + + VP ++I++ CK +I Sbjct: 62 FIVAYAYKANANLAITRLLAKLGCGADVVSGGELYIAKLSNVPSKKIVFNGNCKTKEEII 121 Query: 122 YAANNGVQMMTFDSEVELMKVARAHPK----AKLVLRIATD-DSKAVCRLSV-----KFG 171 ++ DS EL+ + + A + RI + + K ++S KFG Sbjct: 122 MGIEANIRAFNVDSISELILINETAKELGETANVAFRINPNVNPKTHPKISTGLKKNKFG 181 Query: 172 ------ATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEV 225 ++ ++ LE ++VVGV H+GS TD F++ E Sbjct: 182 LDVESGIAMKAIKMALEMEY---VNVVGVHCHIGSQLTDISPFIEETRKVMDFVVELKEE 238 Query: 226 GFSMYLLDIGGGF--PGSEDVKLKFEE--ITGVINPALDKYFPSDSGVRIIAEPGRYYVA 281 G + +++GGG P +D ++ ++ +IN L KY +I EPGR VA Sbjct: 239 GIEIEDVNLGGGLGIPYYKDKQIPTQKDLADAIINTML-KYKDKVEMPNLILEPGRSLVA 297 Query: 282 SAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVKPLLQ 341 +A L + + + T ++ G+ +Y+ H ++ Sbjct: 298 TAGYLLGKV--------------HHIKETPVTKWVMIDAGMNDMMRPAMYEAYH--HIIN 341 Query: 342 KRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQ 401 + K +++ S I G C+ D +L ++ VGD + ++GAY ++ A+ +N Sbjct: 342 CKVKNEKEVVS--IAGGLCESSDVFGRDRELDKVEVGDVLAIFDVGAYGISMANNYNARG 399 Query: 402 RPTIYYVMSGPAWQLMQQFQNP 423 RP + S L+++ + Sbjct: 400 RPRMVLT-SKKGVFLIRERETY 420 >1HKV-A nrPDB Length = 453 Score = 305 bits (782), Expect = 2e-83, Method: Composition-based stats. Identities = 91/424 (21%), Positives = 152/424 (35%), Gaps = 58/424 (13%) Query: 37 KDAFYVADLGDILKKHLRWLKAL-PRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTEI 95 +V D D + A YA K + + ++ G D + E+ Sbjct: 39 GTPLFVIDEDDFRSRCRETAAAFGSGANVHYAAKAFLCSEVARWISEEGLCLDVCTGGEL 98 Query: 96 QLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLV--- 152 + PPERI K VS++ A GV + DS E+ ++ +A +V Sbjct: 99 AVALHASFPPERITLHGNNKSVSELTAAVKAGVGHIVVDSMTEIERLDAIAGEAGIVQDV 158 Query: 153 ---------------LRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFH 197 + A +D K LSV GA + R + ++ +VG+ H Sbjct: 159 LVRLTVGVEAHTHEFISTAHEDQK--FGLSVASGAAMAAVRRVFATD---HLRLVGLHSH 213 Query: 198 VGSGCTDPETFVQAISDARC-----VFDMGAEVGFSMYLLDIGGGF----------PGSE 242 +GS D + F A V + G E + +D+GGG P Sbjct: 214 IGSQIFDVDGFELAAHRVIGLLRDVVGEFGPEKTAQIATVDLGGGLGISYLPSDDPPPIA 273 Query: 243 DVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTG 302 ++ K I + A+ P +++ EPGR I L E Sbjct: 274 ELAAKLGTIVSDESTAVGLPTP-----KLVVEPGRAIAGPG----------TITLYEVGT 318 Query: 303 SDDEDESSEQTFMYY-VNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCD 361 D D S+ Y V+ G+ + LY + L+ + D + + G C+ Sbjct: 319 VKDVDVSATAHRRYVSVDGGMSDNIRTALYGAQYDVRLVSRVS--DAPPVPARLVGKHCE 376 Query: 362 GLDRIVERCDLP-EMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQF 420 D IV +P ++ GD + GAY + +S +N RP + V +G A ++++ Sbjct: 377 SGDIIVRDTWVPDDIRPGDLVAVAATGAYCYSLSSRYNMVGRPAVVAVHAGNARLVLRRE 436 Query: 421 QNPD 424 D Sbjct: 437 TVDD 440 >1KNW-A nrPDB Length = 425 Score = 300 bits (767), Expect = 1e-81, Method: Composition-based stats. Identities = 84/419 (20%), Positives = 154/419 (36%), Gaps = 60/419 (14%) Query: 33 SSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASK 92 ++ +V D I+++ + LK V +A K + I++ + G D S Sbjct: 21 PAEFGCPVWVYDA-QIIRRQIAALKQFDVVR--FAQKACSNIHILRLMREQGVKVDSVSL 77 Query: 93 TEIQLVQSLGVPPER----------IIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKV 142 EI+ + G P+ +I ++VS+++ N G S L ++ Sbjct: 78 GEIERALAAGYNPQTHPDDIVFTADVIDQATLERVSELQIPVNAG-------SVDMLDQL 130 Query: 143 ARAHPKAKLVLRIAT------DDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSF 196 + P ++ LR+ + K G L+ + ++ +VG+ Sbjct: 131 GQVSPGHRVWLRVNPGFGHGHSQKTNTGGENSKHGIWYTDLPAALDVIQRHHLQLVGIHM 190 Query: 197 HVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSE---DVKLKFEEITG 253 H+GSG + R V + G + + + GGG + + E G Sbjct: 191 HIGSGVDYAHLEQVCGAMVRQVIEFGQD----LQAISAGGGLSVPYQQGEEAVDTEHYYG 246 Query: 254 VINPALDKYFPS-DSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQ 312 + N A ++ V++ EPGR+ VA + L + + K Q GS Sbjct: 247 LWNAAREQIARHLGHPVKLEIEPGRFLVAQSGVLITQVRSVK-----QMGSRH------- 294 Query: 313 TFMYYVNDGVYGSFNCILYDHAHVKPLL--QKRPKPDEKYYSSSIWGPTCDGLDRI---- 366 V+ G +Y H L R + + GP C+ D Sbjct: 295 --FVLVDAGFNDLMRPAMYGSYHHISALAADGRSLEHAPTVETVVAGPLCESGDVFTQQE 352 Query: 367 ---VERCDLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVM-SGPAWQLMQQFQ 421 VE LPE+ GD+++ + GAY + +S +N RP + V+ +L+++ Q Sbjct: 353 GGNVETRALPEVKAGDYLVLHDTGAYGASMSSNYN--SRPLLPEVLFDNGQARLIRRRQ 409 >5X7M-A nrPDB Length = 453 Score = 294 bits (752), Expect = 6e-80, Method: Composition-based stats. Identities = 91/413 (22%), Positives = 162/413 (39%), Gaps = 34/413 (8%) Query: 34 SDDKDAFYVADLGDILKKHLRWLKALPRVT-PFYAVKCNDSKAIVKTLAATGTGFDCASK 92 + +V D D + A YA K +K I + + G D AS Sbjct: 39 EEYGTPLFVVDEDDFRSRCRDMATAFGGPGNVHYASKAFLTKTIARWVDEEGLALDIASI 98 Query: 93 TEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVE---LMKVARAHPKA 149 E+ + + G P RI K V ++ NGV + DS E L VA K Sbjct: 99 NELGIALAAGFPASRITAHGNNKGVEFLRALVQNGVGHVVLDSAQELELLDYVAAGEGKI 158 Query: 150 K-LVLRIAT------DDSKAVCRLSVKFGATLRTSR---LLLERAKELNIDVVGVSFHVG 199 + +++R+ + A KFG +L + N+++VG+ HVG Sbjct: 159 QDVLIRVKPGIEAHTHEFIATSHEDQKFGFSLASGSAFEAAKAANNAENLNLVGLHCHVG 218 Query: 200 SGCTDPETFVQAISDARCVFD-MGAEVGFSMYLLDIGGGFPGSE---DVKLKFEEITGVI 255 S D E F A ++ + +E+G ++ LD+GGG+ + + L E+ + Sbjct: 219 SQVFDAEGFKLAAERVLGLYSQIHSELGVALPELDLGGGYGIAYTAAEEPLNVAEVASDL 278 Query: 256 NPALDKYFPSD--SGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQT 313 A+ K ++ EPGR + + + E + D ++T Sbjct: 279 LTAVGKMAAELGIDAPTVLVEPGRAIAGPS----------TVTIYEVGTTKDVHVDDDKT 328 Query: 314 FMYY-VNDGVYGSFNCILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDL 372 Y V+ G+ + LY + ++ + + D S+ I G C+ D ++ Sbjct: 329 RRYIAVDGGMSDNIRPALYGSEYDARVVSRFAEGDP--VSTRIVGSHCESGDILINDEIY 386 Query: 373 P-EMHVGDWMLFENMGAYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPD 424 P ++ GD++ GAY A +S +N F RP + V +G + ++++ D Sbjct: 387 PSDITSGDFLALAATGAYCYAMSSRYNAFTRPAVVSVRAGSSRLMLRRETLDD 439 >2J66-A nrPDB Length = 428 Score = 284 bits (726), Expect = 5e-77, Method: Composition-based stats. Identities = 90/432 (20%), Positives = 184/432 (42%), Gaps = 55/432 (12%) Query: 37 KDAFYVADLGDILKKHLRWLKAL--PRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTE 94 + FY+ D GD ++ H R L++ P + + ++K N++ + K G G + AS E Sbjct: 16 ETPFYLYD-GDFIEAHYRQLRSRTNPAIQFYLSLKANNNIHLAKLFRQWGLGVEVASAGE 74 Query: 95 IQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPK----AK 150 + L + G E II++ P K+ S+++ A +G+ + +S EL + K A+ Sbjct: 75 LALARHAGFSAENIIFSGPGKKRSELEIAVQSGIYCIIAESVEELFYIEELAEKENKTAR 134 Query: 151 LVLRIATDDSKAVCRLSVKFGATLRTSRL-------LLERAKELNI-DVVGVSFHVGSGC 202 + +RI D K+ ++K G R + +++ + L +G+ + G+ Sbjct: 135 VAIRINPD--KSFGSTAIKMGGVPRQFGMDESMLDAVMDAVRSLQFTKFIGIHVYTGTQN 192 Query: 203 TDPETFVQAISDARCVFDMGAEV----GFSMYLLDIGGGFP---GSEDVKLKFEEITGVI 255 + ++ ++++ + D+G + G +++GGGF S + L +IT + Sbjct: 193 LNTDSIIESM---KYTVDLGRNIYERYGIVCECINLGGGFGVPYFSHEKALDIGKITRTV 249 Query: 256 NP----ALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSE 311 + A D FP I E GRY +A A ++ +K +S+ Sbjct: 250 SDYVQEARDTRFPQT---TFIIESGRYLLAQAAVYVTEVLYRK--------------ASK 292 Query: 312 QTFMYYVNDGVY----GSFNC-ILYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRI 366 V+ G++ +F + + ++ + + + +I GP C D + Sbjct: 293 GEVFVIVDGGMHHHAASTFRGRSMRSNYPMEYIPVREDSGRRELEKVTIAGPLCTPEDCL 352 Query: 367 VERCDLPEMHVGDWMLFENMGAYTVAAAS-TFNGFQRPTIYYVMSGPAWQLMQQFQNPDF 425 + +P ++ GD + N GAY ++ + F G P +G +++L+++ D Sbjct: 353 GKDVHVPALYPGDLVCVLNSGAYGLSFSPVHFLGHPTPIEILKRNG-SYELIRRKGTADD 411 Query: 426 PPEVEEQDASTL 437 + Q S L Sbjct: 412 IVATQLQTESNL 423 >3N29-A nrPDB Length = 418 Score = 213 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 78/396 (19%), Positives = 147/396 (37%), Gaps = 31/396 (7%) Query: 37 KDAFYVADLGDILKK--HLRWLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTE 94 + Y+ + + K L + A+K +K + G C+ E Sbjct: 43 QTPAYILEEDKLRKNCELLASVGEKSGAKVLLALKGFAFSGAMKIVGEYLKGCTCSGLWE 102 Query: 95 IQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLR 154 + + + E Y+ K+ + A+ + + F+S + K K L LR Sbjct: 103 AKFAKEY-MDKEIHTYSPAFKEDEIGEIASLS--HHIVFNSLAQFHKFQSKTQKNSLGLR 159 Query: 155 IATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGV-SFHVGSGCTDPETFVQAIS 213 + S A L G R SRL + N+D+ + H + C + ++A+ Sbjct: 160 CNVEFSLAPKELYNPCG---RYSRLGIRAKDFENVDLNAIEGLHFHALCEESADALEAVL 216 Query: 214 DARCVFD--MGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRI 271 VF+ G +G M ++ GGG + K ++ +I AL K F GV++ Sbjct: 217 K---VFEEKFGKWIG-QMKWVNFGGG----HHITKKGYDVEKLI--ALCKNFSDKYGVQV 266 Query: 272 IAEPGRYYVASAFTLAVNI--IAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCI 329 EPG L ++ I + + E + M Y ++ + Sbjct: 267 YLEPGEAVGWQTGNLVASVVDIIENEKQIAILDTSSEAHMPDTIIMPYTSE--------V 318 Query: 330 LYDHAHVKPLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMGAY 389 L +K E ++ + G TC D + E ++ +GD ++F + Y Sbjct: 319 LNARILATRENEKISDLKENEFAYLLTGNTCLAGDVMGEYAFDKKLKIGDKIVFLDQIHY 378 Query: 390 TVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDF 425 T+ +TFNG + P + + Q++++F D+ Sbjct: 379 TIVKNTTFNGIRLPNLMLLDHKNELQMIREFSYKDY 414 >3MT1-A nrPDB Length = 365 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 72/398 (18%), Positives = 138/398 (34%), Gaps = 49/398 (12%) Query: 37 KDAFYVADLGDILKKHLR--WLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTE 94 + +Y+ D + + R ++ A+KC + ++ + G +S E Sbjct: 3 ETPYYLIDKAKLTRNMERIAHVREKSGAKALLALKCFATWSVFDLMRDYMDGTTSSSLFE 62 Query: 95 IQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVELMKVARAHPKAKLVLR 154 ++L + E Y+ ++I + + F+S +L + A LR Sbjct: 63 VRLGRER-FGKETHAYS-VAYGDNEIDEVV-SHADKIIFNSISQLERFADKAAGIARGLR 119 Query: 155 IATDDSKAVCRLSVKFGATLRTSRLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISD 214 + S + L+ R + + + + + G H D F + + + Sbjct: 120 LNPQVSSSSFDLADPARPFSRLGEWDVPKVERVMDRINGFMIHNNCENKDFGLFDRMLGE 179 Query: 215 ARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAE 274 F + + +GGG + ++ A + F GV+I E Sbjct: 180 IEERFGALIAR---VDWVSLGGGIHFT------GDDYPVDAFSARLRAFSDRYGVQIYLE 230 Query: 275 PGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYD-- 332 PG + + TL V ++ D +Y N + D Sbjct: 231 PGEASITKSTTLEVTVL----------------------------DTLYNGKNLAIVDSS 262 Query: 333 -HAHVKPLLQKRPK----PDEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENMG 387 AH+ LL R P+E +S I G +C D E E+ VGD + F++ Sbjct: 263 IEAHMLDLLIYRETAKVLPNEGSHSYMICGKSCLAGDVFGEFRFAEELKVGDRISFQDAA 322 Query: 388 AYTVAAASTFNGFQRPTIYYVMSGPAWQLMQQFQNPDF 425 YT+ + FNG + P I + + +++F D+ Sbjct: 323 GYTMVKKNWFNGVKMPAIAIRELDGSVRTVREFTYADY 360 >3NZP-A nrPDB Length = 619 Score = 94.1 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 54/294 (18%), Positives = 102/294 (34%), Gaps = 37/294 (12%) Query: 66 YAVKCNDSKAIVKTLAATG----TGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIK 121 Y +K N VK L G G + SK E+ L + I K I Sbjct: 83 YPLKVNQYPGFVKNLVKLGKDYNYGLEAGSKAELLLAMAYNNEGAPITVNG-FKDRELIN 141 Query: 122 Y---AANNGVQM-MTFDSEVELMKV-----ARAHPKAKLVLRIATDDSKAV-----CRLS 167 AA G + +T + EL + R PK + LR+ + ++ Sbjct: 142 IGFIAAEMGHNITLTIEGLNELEAIIDIAKERFKPKPNIGLRVRLHSAGVGIWAKSGGIN 201 Query: 168 VKFGATLRTSRLLLERAKELNI--DVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEV 225 KFG T + KE + + FH+GS T+ +A+++A ++ ++ Sbjct: 202 SKFGLTSTELIEAVNLLKENKLLEQFTMIHFHLGSQITEIHPLKKALNEAGNIYTELRKM 261 Query: 226 GF-SMYLLDIGGG-------FPGSEDVKLKFEEITGVINPALDKYFPSDSGVR--IIAEP 275 G ++ +++GGG F + E + L + I E Sbjct: 262 GAKNLKAINLGGGLAVEYSQFKNEKSRNYTLREYANDVVFILKNIAEQKKDLEPDIFIES 321 Query: 276 GRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYGSFNCI 329 GR+ A+ L ++ + + ++ + +++ +Y + I Sbjct: 322 GRFVAANHAVLIAPVLELFSQEYAENKLILKKQNPK-----LIDE-LYDLYKSI 369 Score = 35.9 bits (81), Expect = 0.041, Method: Composition-based stats. Identities = 35/138 (25%), Positives = 54/138 (39%), Gaps = 12/138 (8%) Query: 281 ASAFTLAVNIIAKKIVLK---EQTGSDDEDESSEQTFMYYVNDGVYGSFNCILYDHAHVK 337 ++A L ++I KK +L +Q +D E Y VN ++ S + Sbjct: 403 SNAEIL-THLITKKAILLLGDKQNPADLLAIQDEVQERYLVNFSLFQSM-PDFWGLEQNF 460 Query: 338 PLLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCDLPE-MHVGD------WMLFENMGAYT 390 P++ +E S+SIW TCD I D P +H D ++ F +GAY Sbjct: 461 PIMPLDRLDEEPTRSASIWDITCDSDGEISYSKDKPLFLHDVDVEKENYFLGFFLVGAYQ 520 Query: 391 VAAASTFNGFQRPTIYYV 408 N F PT + Sbjct: 521 EVLGMKHNLFTHPTEAII 538 >3N2O-A nrPDB Length = 648 Score = 89.8 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 58/279 (20%), Positives = 104/279 (37%), Gaps = 39/279 (13%) Query: 66 YAVKCNDSKAIV-KTLAATG------TGFDCASKTEIQLVQSLGVPPERIIYANPCKQVS 118 Y +K N + +V + LA+ G + SK E+ V ++ +I N K Sbjct: 102 YPIKVNQQREVVDEILASQAQLETKQLGLEAGSKPELLAVLAMAQHASSVIVCNGYKDRE 161 Query: 119 QIKYAA---NNGVQMMTF-DSEVELMKVAR------AHPKAKLVLRIATDDS---KAVCR 165 I+ A G ++ + EL V R P+ + +R+A+ + +A Sbjct: 162 YIRLALIGEKLGHKVFIVLEKMSELDLVLREAKSLGVTPRLGIRIRLASQGAGKWQASGG 221 Query: 166 LSVKFGATLRTSRLLLERAKELN----IDVVGVSFHVGSGCTDPETFVQAISDARCVFDM 221 KFG + ++ R K+ N + + V FH+GS + ++++ + Sbjct: 222 EKSKFGLSASQVLNVISRLKKENQLDTLQL--VHFHLGSQMANIRDVRNGVNESARFYCE 279 Query: 222 GAEVGFSMYLLDIGGGFPGSEDVKLK----------FEEITGVINP--ALDKYFPSDSGV 269 +G ++ D+GGG D E ++N + K + V Sbjct: 280 LRTLGANITYFDVGGGLAIDYDGTRSQSSNSMNYGLVEYARNIVNTVGDVCKDYKQPMPV 339 Query: 270 RIIAEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDE 308 II+E GR A L N+I + E +ED Sbjct: 340 -IISESGRSLTAHHAVLISNVIGTETYKPETVTEPEEDF 377 >3NZQ-A nrPDB Length = 666 Score = 89.0 bits (219), Expect = 4e-18, Method: Composition-based stats. Identities = 56/312 (17%), Positives = 102/312 (32%), Gaps = 39/312 (12%) Query: 66 YAVKCNDSKAIVKTLAATG--TGFDCASKTEIQLVQ-SLGVPPERIIYANPCKQVSQIKY 122 Y +K N + ++++L +G G + SK E+ V G+ I+ K I+ Sbjct: 124 YPIKVNQHRRVIESLIHSGEPLGLEAGSKAELMAVLAHAGMTRSVIVCNG-YKDREYIRL 182 Query: 123 AA---NNGVQM-MTFDSEVELMKVARAHPKAKLVLRIATDDSKAV---------CRLSVK 169 A G ++ + + E+ V + +V R+ A K Sbjct: 183 ALIGEKMGHKVYLVIEKMSEIAIVLDEAERLNVVPRLGVRARLASQGSGKWQSSGGEKSK 242 Query: 170 FGATLRTSRLLLERAKELN----IDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEV 225 FG L+E +E + + + FH+GS + + ++ + ++ Sbjct: 243 FGLAATQVLQLVETLREAGRLDSLQL--LHFHLGSQMANIRDIATGVRESARFYVELHKL 300 Query: 226 GFSMYLLDIGGGFPGSED---------VKLKFEEITGVINPALDKYFPSD--SGVRIIAE 274 G ++ D+GGG + V E I A+ + +I E Sbjct: 301 GVNIQCFDVGGGLGVDYEGTRSQSDCSVNYGLNEYANNIIWAIGDACEENGLPHPTVITE 360 Query: 275 PGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSE-----QTFMYYVNDGVYGSFNCI 329 GR A L NII + + ED +T+ G S Sbjct: 361 SGRAVTAHHTVLVSNIIGVERNEYTVPTAPAEDAPRALQSMWETWQEMHEPGTRRSLREW 420 Query: 330 LYDHAHVKPLLQ 341 L+D + Sbjct: 421 LHDSQMDLHDIH 432 >3KS6-A nrPDB Length = 250 Score = 35.5 bits (80), Expect = 0.044, Method: Composition-based stats. Identities = 25/100 (25%), Positives = 39/100 (39%), Gaps = 8/100 (8%) Query: 38 DAFYVADLGDILKKHLR---WLKALPRVTPFYAVKCNDSKAIVKTLAATGTGFDCASKTE 94 +F +A + ++ K R WL + P V AI ++ G D A Sbjct: 138 SSFLLASMDELWKATTRPRLWLVS-PSVLQQLGPGAVIETAIAHSIHEIGVHIDTADAGL 196 Query: 95 IQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFD 134 + VQ+ G+ P SQI A + GV++ T D Sbjct: 197 MAQVQAAGLDFGCWAAHTP----SQITKALDLGVKVFTTD 232 >6NXI-A nrPDB Length = 328 Score = 34.7 bits (78), Expect = 0.074, Method: Composition-based stats. Identities = 29/126 (23%), Positives = 50/126 (39%), Gaps = 18/126 (14%) Query: 171 GATLRTSRLLLERAKELNID--VVGV-SFHVGSGCTD---PETFVQAISDARC-----VF 219 G ++ +ELN + G+ + PE +V + A+ V Sbjct: 107 GFGPEARPDVVPTDEELNARRAITGIEHLTIEGNTLSKDIPELYVDLSTIAKGWGVDVVA 166 Query: 220 DMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGV-INPALDKYFPSDSGVRIIAEPGRY 278 D G Y+++IGG +++LK GV A++K V+ I EPG Y Sbjct: 167 DYLQSQGIENYMVEIGG------EIRLKGLNRDGVPWRIAIEKPSVDQRSVQEIIEPGDY 220 Query: 279 YVASAF 284 +A++ Sbjct: 221 AIATSG 226 >4DEF-A nrPDB Length = 349 Score = 32.4 bits (72), Expect = 0.43, Method: Composition-based stats. Identities = 12/56 (21%), Positives = 23/56 (41%), Gaps = 5/56 (8%) Query: 88 DCASKTEIQLVQSLGVP----PERIIYAN-PCKQVSQIKYAANNGVQMMTFDSEVE 138 D ++ + LG+P P ++ S+I+ A GV M D++ + Sbjct: 225 DILAQGQQVAAAKLGLPADAKPFDFVFHGGSGSLKSEIEEALRYGVVKMNVDTDTQ 280 >3MBD-A nrPDB Length = 342 Score = 32.0 bits (71), Expect = 0.60, Method: Composition-based stats. Identities = 22/107 (20%), Positives = 41/107 (38%), Gaps = 3/107 (2%) Query: 130 MMTFDSEVELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLRTSRLLLERAKELNI 189 MM D + L A+ + + A + K + R K G T + +E+ Sbjct: 5 MMDCDHLLRLGMTAKKILENGKGILAADETPKTLGRRFEKLGITNTEENR--RKFREILF 62 Query: 190 DVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYL-LDIG 235 G+ ++G + ETF Q + ++ + G + + LD G Sbjct: 63 STKGIERYIGGVILNQETFEQTSGSGVPLTELLKKKGIEIGIKLDKG 109 >5LDA-A nrPDB Length = 130 Score = 30.1 bits (66), Expect = 1.9, Method: Composition-based stats. Identities = 10/32 (31%), Positives = 17/32 (53%), Gaps = 1/32 (3%) Query: 168 VKFGATLRTSRLLLERAKELNIDVVGV-SFHV 198 V+F LE A++ N++VVG+ H+ Sbjct: 50 VEFEMDPEEMLKALEEAEQENLEVVGIFHSHI 81 >6NBP-A nrPDB Length = 263 Score = 29.3 bits (64), Expect = 3.4, Method: Composition-based stats. Identities = 17/58 (29%), Positives = 24/58 (41%), Gaps = 2/58 (3%) Query: 12 HFLDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDILKKHLRWLKALPRVTPFYAVK 69 H +D DI+DQ+ EV SD + V ++KHL +T Y K Sbjct: 142 HLMDAEVDHGDIIDQQEVEVKMSD--TSLTVYRKVIAIEKHLISRNIFTIITRSYTTK 197 >5KLK-A nrPDB Length = 520 Score = 29.3 bits (64), Expect = 3.9, Method: Composition-based stats. Identities = 35/192 (18%), Positives = 65/192 (33%), Gaps = 36/192 (18%) Query: 84 GTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFD----SEVEL 139 G G D S E L Q G+ + + K S I A +GV+ ++F+ + + Sbjct: 243 GFGKD--SAGEF-LTQHPGISA--LTFTGESKTGSTIMKAVADGVKEVSFELGGKNAAVV 297 Query: 140 MKVARAHPKAKLVLRIATDDSKAVCRLSVK------------FGATLRTSRLLLERAKEL 187 A + VLR + +S VC S + G + RL++ + Sbjct: 298 FADADLDAAIEGVLRSSFTNSGQVCLCSERVYVHRSIFDEFVSGLKVEAERLVVGYPDQD 357 Query: 188 NIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLK 247 +++ + H + + + G ++ GGG P D + + Sbjct: 358 GVNMGPLISHGHR------------DKVLSYYRLAVDEGATVVT---GGGVPKFNDERDQ 402 Query: 248 FEEITGVINPAL 259 + I L Sbjct: 403 GAYVQPTIWTGL 414 >2MA1-A nrPDB Length = 75 Score = 29.0 bits (63), Expect = 5.0, Method: Composition-based stats. Identities = 6/32 (18%), Positives = 17/32 (53%) Query: 95 IQLVQSLGVPPERIIYANPCKQVSQIKYAANN 126 +Q + L +PP I + K +++++ ++ Sbjct: 14 LQKAKELSLPPYTIFHDATLKTIAELRPGSHA 45 >5BSW-A nrPDB Length = 541 Score = 28.6 bits (62), Expect = 6.9, Method: Composition-based stats. Identities = 18/82 (21%), Positives = 30/82 (36%), Gaps = 4/82 (4%) Query: 96 QLVQSLGVPPERIIYANPCKQVSQIKYAANNGVQMMTFDSEVE----LMKVARAHPKAKL 151 ++V+ +II C YA N V+++ DS E + +A+ Sbjct: 115 EVVKQAKASSAKIIVTQACHVNKVKDYAFENDVKIICIDSAPEGCLHFSVLTQANEHDIP 174 Query: 152 VLRIATDDSKAVCRLSVKFGAT 173 + I DD A+ S G Sbjct: 175 EVEIQPDDVVALPYSSGTTGLP 196 >5DA8-A nrPDB Length = 545 Score = 28.2 bits (61), Expect = 7.3, Method: Composition-based stats. Identities = 21/117 (17%), Positives = 37/117 (31%), Gaps = 20/117 (17%) Query: 212 ISDARCVFDMGAEVGFSMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRI 271 + DA + G +GGG + A+ +G+ I Sbjct: 396 VEDALHATRAAVQEGIV-----VGGGVALIR--------AAKGLAKAVADNEDQKTGIEI 442 Query: 272 I----AEPGRYYVASAFTLAVNIIAKKIVLKEQTGSDDEDESSEQTFMYYVNDGVYG 324 I EP R VA+ T ++ +K+ E D + + + + GV Sbjct: 443 IRRALEEPLRQIVANTGTTDGAVVLEKVKNAEG---DYGFNARTEQYENLIEAGVVD 496 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.127 0.328 Lambda K H 0.267 0.0390 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,293,666 Number of Sequences: 36641 Number of extensions: 608945 Number of successful extensions: 1907 Number of sequences better than 10.0: 36 Number of HSP's better than 10.0 without gapping: 47 Number of HSP's successfully gapped in prelim test: 20 Number of HSP's that attempted gapping in prelim test: 1730 Number of HSP's gapped (non-prelim): 75 length of query: 461 length of database: 10,336,785 effective HSP length: 100 effective length of query: 361 effective length of database: 6,672,685 effective search space: 2408839285 effective search space used: 2408839285 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 61 (28.2 bits)