BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P11883 (453 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1AD3-A nrPDB 943 0.0 3SZA-A nrPDB 795 0.0 4QGK-A nrPDB 634 0.0 5NNO-A nrPDB 387 e-108 5UCD-A nrPDB 304 5e-83 6QAO-A nrPDB 162 3e-40 5EUY-A nrPDB 161 6e-40 3TY7-A nrPDB 159 2e-39 5FHZ-A nrPDB 159 3e-39 5AC0-A nrPDB 158 5e-39 5AC2-A nrPDB 157 1e-38 4PXL-B nrPDB 156 2e-38 4V3F-A nrPDB 155 3e-38 3B4W-A nrPDB 154 9e-38 1O9J-A nrPDB 152 3e-37 4I8P-A nrPDB 150 8e-37 4CAZ-A nrPDB 150 8e-37 4O5H-A nrPDB 150 1e-36 4YWE-A nrPDB 149 3e-36 3IWK-A nrPDB 149 3e-36 2HG2-A nrPDB 149 3e-36 3VZ3-A nrPDB 148 4e-36 4PZ2-A nrPDB 147 6e-36 3U4J-A nrPDB 147 8e-36 4GO4-A nrPDB 147 1e-35 4H7N-A nrPDB 146 2e-35 5L13-A nrPDB 146 2e-35 5GT6-A nrPDB 145 3e-35 3K2W-A nrPDB 145 3e-35 1BPW-A nrPDB 143 1e-34 1AG8-A nrPDB 142 2e-34 4I8Q-A nrPDB 142 3e-34 3RJL-A nrPDB 142 3e-34 3IWJ-A nrPDB 142 3e-34 4O6R-A nrPDB 142 4e-34 4LIH-A nrPDB 141 6e-34 3QAN-A nrPDB 140 2e-33 4X2Q-A nrPDB 139 3e-33 4MPY-A nrPDB 139 3e-33 5X5U-A nrPDB 139 3e-33 6FK3-A nrPDB 137 8e-33 3I44-A nrPDB 137 1e-32 3R31-A nrPDB 137 1e-32 4V6H-A nrPDB 137 1e-32 6C43-A nrPDB 137 1e-32 5UR2-A nrPDB 137 1e-32 4QYJ-A nrPDB 137 1e-32 3RHD-A nrPDB 136 2e-32 3JZ4-A nrPDB 136 2e-32 5J77-A nrPDB 135 5e-32 2D4E-A nrPDB 134 1e-31 6MVR-A nrPDB 133 2e-31 3PRL-A nrPDB 132 3e-31 3VZ0-A nrPDB 132 3e-31 4DNG-A nrPDB 130 1e-30 2QE0-A nrPDB 129 4e-30 4F3X-A nrPDB 126 2e-29 6B4R-B nrPDB 125 3e-29 5VBF-A nrPDB 123 2e-28 3RHO-A nrPDB 122 2e-28 1WNB-A nrPDB 122 4e-28 3R64-A nrPDB 121 6e-28 5KLK-A nrPDB 119 2e-27 5KF0-A nrPDB 119 2e-27 2W8P-A nrPDB 119 2e-27 5IUV-A nrPDB 119 3e-27 2J5N-A nrPDB 119 4e-27 3EFV-A nrPDB 116 2e-26 3RH9-A nrPDB 115 3e-26 1UXV-A nrPDB 115 3e-26 3EK1-A nrPDB 115 4e-26 4I3V-A nrPDB 114 7e-26 5JRY-A nrPDB 114 9e-26 5U0M-A nrPDB 112 3e-25 2JG7-A nrPDB 112 3e-25 5N5S-A nrPDB 110 9e-25 4JZ6-A nrPDB 109 2e-24 3JU8-A nrPDB 108 4e-24 1T90-A nrPDB 107 1e-23 4OGD-A nrPDB 107 1e-23 5J6B-A nrPDB 105 3e-23 4PXN-A nrPDB 102 3e-22 5TJR-A nrPDB 101 8e-22 4U3W-A nrPDB 101 8e-22 3ROS-A nrPDB 99 4e-21 4X0T-A nrPDB 99 5e-21 4ZZ7-A nrPDB 94 1e-19 4E4G-A nrPDB 91 1e-18 4KNA-A nrPDB 90 2e-18 6DBB-A nrPDB 78 8e-15 3V9H-A nrPDB 74 1e-13 4LGZ-A nrPDB 72 3e-13 4OE4-A nrPDB 70 3e-12 5JFN-A nrPDB 62 4e-10 5UJU-A nrPDB 60 2e-09 5J7I-A nrPDB 55 5e-08 4IDS-A nrPDB 54 1e-07 5DBV-A nrPDB 43 3e-04 1O20-A nrPDB 40 0.001 3V4C-A nrPDB 39 0.004 2Y53-A nrPDB 37 0.016 6D97-A nrPDB 34 0.11 3K9D-A nrPDB 34 0.15 2H5G-A nrPDB 32 0.49 6G4F-A nrPDB 32 0.65 3EDP-A nrPDB 32 0.80 5SWI-B nrPDB 28 7.6 >1AD3-A nrPDB Length = 452 Score = 943 bits (2438), Expect = 0.0, Method: Compositional matrix adjust. Identities = 451/451 (100%), Positives = 451/451 (100%) Query: 3 SISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE 62 SISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE Sbjct: 2 SISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE 61 Query: 63 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTI 122 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTI Sbjct: 62 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTI 121 Query: 123 QPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLKERFD 182 QPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLKERFD Sbjct: 122 QPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLKERFD 181 Query: 183 HIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQ 242 HIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQ Sbjct: 182 HIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQ 241 Query: 243 TCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQK 302 TCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQK Sbjct: 242 TCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQK 301 Query: 303 VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPL 362 VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPL Sbjct: 302 VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPL 361 Query: 363 ALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETF 422 ALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETF Sbjct: 362 ALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETF 421 Query: 423 SHRRSCLVKSLLNEEAHKARYPPSPAKMPRH 453 SHRRSCLVKSLLNEEAHKARYPPSPAKMPRH Sbjct: 422 SHRRSCLVKSLLNEEAHKARYPPSPAKMPRH 452 >3SZA-A nrPDB Length = 469 Score = 795 bits (2052), Expect = 0.0, Method: Compositional matrix adjust. Identities = 371/453 (81%), Positives = 416/453 (91%) Query: 1 MSSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 MS IS+ VKRAR AF+SG+TR LQFRIQQLEALQR+I E + + GALA+DL KNEW +Y Sbjct: 17 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 76 Query: 61 YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNL 120 YEEV +VLEE++ I++LP+WA DEPV KT QTQQD+LYIHSEPLGVVLVIG WNYPFNL Sbjct: 77 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 136 Query: 121 TIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLKER 180 TIQPMVGA+AAGNAV+LKPSE+S +MA LLAT+IPQY+D++LY V+ GGVPETTELLKER Sbjct: 137 TIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 196 Query: 181 FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNS 240 FDHI+YTGST VGKI+M AAAKHLTPVTLELGGKSPCYVDK+CDLDVACRRIAWGKFMNS Sbjct: 197 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 256 Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDN 300 GQTCVAPDYILCDPSIQNQIVEKLKKSLK+FYGEDAK+SRDYGRII+ RHFQRV GLI+ Sbjct: 257 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 316 Query: 301 QKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREK 360 QKVA+GGT D ++RYIAPTIL DVDPQSPVMQEEIFGPV+PIVCVRSLEEAIQFINQREK Sbjct: 317 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 376 Query: 361 PLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFE 420 PLALY+FS+N+KVIKKMIAETSSGGV ANDVIVHIT+ +LPFGGVGNSGMG+YHGKKSFE Sbjct: 377 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 436 Query: 421 TFSHRRSCLVKSLLNEEAHKARYPPSPAKMPRH 453 TFSHRRSCLV+ L+N+E K RYPPSPAKM +H Sbjct: 437 TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH 469 >4QGK-A nrPDB Length = 461 Score = 634 bits (1636), Expect = 0.0, Method: Compositional matrix adjust. Identities = 290/439 (66%), Positives = 368/439 (83%) Query: 8 VKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHV 67 V+R R+AF SG++R L+FR+QQLEAL+RM+ E K I A+A+DL K+E+ Y +EV V Sbjct: 6 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 65 Query: 68 LEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVG 127 L E+D ++ LP+W +PV K T D+ YI +PLGVVL+IGAWNYPF LTIQP++G Sbjct: 66 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 125 Query: 128 AVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLKERFDHIMYT 187 A+AAGNAVI+KPSE+S + A +LA L+PQY+DQ+LY+V+ GGV ETTELLK+RFDHI YT Sbjct: 126 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 185 Query: 188 GSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAP 247 G+TAVGKIVM AAAKHLTPVTLELGGKSPCY+DKDCDLD+ CRRI WGK+MN GQTC+AP Sbjct: 186 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 245 Query: 248 DYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQKVAHGG 307 DYILC+ S+QNQIV K+K+++K+FYGE+ K+S DY RIIN RHF+R+ L++ QK+A GG Sbjct: 246 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 305 Query: 308 TWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVF 367 D+++RYIAPT+L DVDP++ VMQEEIFGP++PIV V++++EAI FIN+REKPLALYVF Sbjct: 306 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 365 Query: 368 SNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRS 427 S+N K+IK+MI ETSSGGVT NDVI+H T+ + PFGGVG+SGMGAYHGK SF+TFSH+R Sbjct: 366 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 425 Query: 428 CLVKSLLNEEAHKARYPPS 446 CL+KSL E A+K RYPP+ Sbjct: 426 CLLKSLKREGANKLRYPPN 444 >5NNO-A nrPDB Length = 546 Score = 387 bits (993), Expect = e-108, Method: Compositional matrix adjust. Identities = 216/472 (45%), Positives = 294/472 (62%), Gaps = 36/472 (7%) Query: 1 MSSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKN----- 55 + +I V + REAFN R L+ R Q L +L ++ EN A+ D ++ Sbjct: 14 LENIPVIVSKCREAFNDDANRDLKKRKQVLRSLLNLVEENTDEFCKAIHRDRRRHRDETV 73 Query: 56 --EWTSYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQ--TQQDDLYIHSEPLGVVLVI 111 E EV H++E +D +K PV T + DD + EPLGVVLVI Sbjct: 74 VMEILPLRNEVWHLIEHMDEYVK---------PVKPTMEGAAALDDCELQYEPLGVVLVI 124 Query: 112 GAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVP 171 G WNYP L +QP++GA+AAGN ++KPSE++ A+LL L+P+Y+ ++ +V GGV Sbjct: 125 GTWNYPLLLILQPLLGALAAGNTAVIKPSELAPATAELLTKLLPKYVSSDVVGIVNGGVS 184 Query: 172 ETTELLKERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDC--DLDVAC 229 ETT +LKERFDHI+YTGS V +IVMAAAAKHLTPVTLELGGKSP VD C ++ V Sbjct: 185 ETTAVLKERFDHILYTGSARVAEIVMAAAAKHLTPVTLELGGKSPVVVDDTCADNMKVVA 244 Query: 230 RRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGED----------AKQS 279 RI WGK +N+GQT +APDY++ + S+++ +V+ L ++ K G+ KQ Sbjct: 245 ERIMWGKIINAGQTSIAPDYVVVEKSMESVLVDALAEARKAMLGDKFLKVLKGELLVKQK 304 Query: 280 R------DYGRIINDRHFQRVKGLIDNQKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQE 333 + DY RI+N HFQR+ + KVA GG D+++ IAPTIL ++DP PVMQE Sbjct: 305 QQFLEESDYPRIVNASHFQRLMEFMKGGKVAVGGEADEATLTIAPTILTNIDPTHPVMQE 364 Query: 334 EIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIV 393 EIFGP++P++ + ++ ++ IN REKPLALYVFSNN++ I+ + + TSSG V NDV+V Sbjct: 365 EIFGPILPVLTYENEKDILKIINSREKPLALYVFSNNKRFIRGVESRTSSGAVVVNDVVV 424 Query: 394 HITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVKSLLNEEAHKARYPP 445 H LPFGGVG SGMGAYHG+ SFETFSHRR + + L R+PP Sbjct: 425 HAGADGLPFGGVGRSGMGAYHGRYSFETFSHRRPVMRRGFLFSSIDTVRFPP 476 >5UCD-A nrPDB Length = 457 Score = 304 bits (779), Expect = 5e-83, Method: Compositional matrix adjust. Identities = 163/429 (37%), Positives = 249/429 (58%), Gaps = 8/429 (1%) Query: 6 DTVKRAREA-FNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEV 64 D++ A++A F + T + FR Q LE L+ + N +++ ALA DLGK + E+ Sbjct: 31 DSLFSAQKAYFATRATADVGFRKQSLERLKEAVINNKEALYSALAEDLGKPKDVVDLAEI 90 Query: 65 AHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQP 124 VL E+D + L +W V + Y+ EP GV +IG +NYP NLT+ P Sbjct: 91 GAVLHEIDFALAHLDEWVAPVSVPSPDIIAPSECYVVQEPYGVTYIIGPFNYPVNLTLTP 150 Query: 125 MVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLKERFDHI 184 ++GA+ GN I+KPSE + + ++ +I + V++GG E + LL FD I Sbjct: 151 LIGAIIGGNTCIIKPSETTPETSAVIEKIIAEAFAPEYVAVIQGGRDENSHLLSLPFDFI 210 Query: 185 MYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTC 244 +TGS VGK+VM AAAKHLTPV LELGGK P V D DLD ++ +GKF+NSGQT Sbjct: 211 FFTGSPNVGKVVMQAAAKHLTPVVLELGGKCPLIVLPDADLDQTVNQLMFGKFINSGQTX 270 Query: 245 VAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLID--NQK 302 +APDY+ S+++ ++E+L + +K + + G+++ +R QR+ L++ + Sbjct: 271 IAPDYLYVHYSVKDALLERLVERVK----TELPEINSTGKLVTERQVQRLVSLLEATQGQ 326 Query: 303 VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQRE-KP 361 V G D S R ++ T++ V+ P+M EE+FGP++P++ S+ AI +N+ KP Sbjct: 327 VLVGSQADVSKRALSATVVDGVEWNDPLMSEELFGPILPVLEFDSVRTAIDQVNKHHPKP 386 Query: 362 LALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFET 421 LA+YVF + V K +I + SG N V++H P LPFGG+G SGMG YHG S+ T Sbjct: 387 LAVYVFGKDMDVAKGIINQIQSGDAQVNGVMLHAFSPYLPFGGIGASGMGEYHGHFSYLT 446 Query: 422 FSHRRSCLV 430 F+H++S + Sbjct: 447 FTHKKSVRI 455 >6QAO-A nrPDB Length = 508 Score = 162 bits (410), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 109/349 (31%), Positives = 173/349 (49%), Gaps = 19/349 (5%) Query: 99 YIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY- 157 Y EPLGV + IGAWNYPF + A+A GNA++ KPS + A LLA + + Sbjct: 155 YTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAG 214 Query: 158 MDQNLYLVVKGGVPETTELLKERFD--HIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKS 215 + L+ VV+GG T + L + D + +TGS G +M +AK + PVTLELGGKS Sbjct: 215 VPPGLFNVVQGGA-ATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKS 273 Query: 216 PCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKDFYGE 274 P + DCD++ A + F+ GQ C + I ++ E+ +K++ + G+ Sbjct: 274 PLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGD 333 Query: 275 DAKQSRDYGRIINDRHFQRVKGLI-----DNQKVAHGGTWD-------QSSRYIAPTILV 322 + G +IN H +RV G + KV GG + Y+ P +L Sbjct: 334 PLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLT 393 Query: 323 DVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETS 382 + ++EEIFGPVM I+ + E ++ N LA VF+ + + +++AE Sbjct: 394 NCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQ 453 Query: 383 SGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVK 431 +G N+ +++ LPFGG SG G +G+ + E +S ++ V+ Sbjct: 454 AGTCFINN--YNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVE 500 >5EUY-A nrPDB Length = 491 Score = 161 bits (407), Expect = 6e-40, Method: Compositional matrix adjust. Identities = 101/334 (30%), Positives = 171/334 (51%), Gaps = 11/334 (3%) Query: 106 GVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYL 164 GVV VI WNYP +++++ + +A GN V+ KP+ + L+A ++ + + + ++ Sbjct: 146 GVVGVITPWNYPLSISMKKIAHTLAVGNTVVYKPASDTPVTGWLIAQMVAKAGLPKGVFN 205 Query: 165 VVKGGVPETTE--LLKERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKD 222 +V G P E + +R H+ +TG ++ G+ + A AA L VTLELGG P + D Sbjct: 206 LVIGPGPVVGEEIVTHKRVAHVTFTGESSTGREIAAKAAGTLKTVTLELGGSDPLIILDD 265 Query: 223 CDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSR-- 280 D+D A R + + GQ C + I+ ++ ++ +E+ +K +D ++ Sbjct: 266 VDVDYAARLAVFASLFHQGQICTSAKRIIVHKAVADKFIERYVHYVKMLRIDDPRKDEKV 325 Query: 281 DYGRIINDRHFQRVKGLIDNQKVAHGGTWDQSSR----YIAPTILVDVDPQSPVMQEEIF 336 D G +IN+R +K +D+ V+ GG R + P I VDVD +M+EE+F Sbjct: 326 DLGPLINERQVALMKEFVDDA-VSRGGRLLIGGRSWGNFFEPAIFVDVDRNFRIMREEVF 384 Query: 337 GPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHIT 396 GPV PIV V + ++A++ N + L+ V +NN ++ SG NDV + Sbjct: 385 GPVRPIVVVENDDQAVEVANDTDYGLSGAVLTNNVNRAFRIAEAVESGMFHINDV-TFLE 443 Query: 397 VPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLV 430 +PFGG+ SG+G G+ SF ++ R V Sbjct: 444 ESHVPFGGIKASGVGREGGEWSFHETTYDRWVTV 477 >3TY7-A nrPDB Length = 478 Score = 159 bits (403), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 111/350 (31%), Positives = 170/350 (48%), Gaps = 17/350 (4%) Query: 92 QTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLA 151 + + DDL + E +GV +I WN+P N T + A AAG+ V+LKPSE + A +LA Sbjct: 128 ERRGDDLVVK-EAIGVSGLITPWNFPTNQTSLKLAAAFAAGSPVVLKPSEETPFAAVILA 186 Query: 152 TLIPQY-MDQNLYLVVKGGVPETTELLKE--RFDHIMYTGSTAVGKIVMAAAAKHLTPVT 208 + + + + ++ +V G L E + + +TGS G +M AAK V+ Sbjct: 187 EIFDKVGVPKGVFNLVNGDGAGVGNPLSEHPKVRMMSFTGSGPTGSKIMEKAAKDFKKVS 246 Query: 209 LELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSL 268 LELGGKSP V D D+ A + N+GQ C A +L I++ + +LK+ Sbjct: 247 LELGGKSPYIVLDDVDIKEAAKATTGKVVNNTGQVCTAGTRVLVPNKIKDAFLAELKEQF 306 Query: 269 KDF-YGEDAKQSRDYGRIINDRHFQRV-----KGLIDNQKVAHGGTWD----QSSRYIAP 318 G + G II+ + F +V KG+ + ++ +GG + + P Sbjct: 307 SQVRVGNPREDGTQVGPIISKKQFDQVQNYINKGIEEGAELFYGGPGKPEGLEKGYFARP 366 Query: 319 TILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMI 378 TI ++VD Q + QEEIFGPVM ++ L+EAIQ N + LA YV +++ + K+ Sbjct: 367 TIFINVDNQMTIAQEEIFGPVMSVITYNDLDEAIQIANDTKYGLAGYVIGKDKETLHKVA 426 Query: 379 AETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSC 428 +G V N+ P LPFGG SG+G G E F +S Sbjct: 427 RSIEAGTVEINEAGRK---PDLPFGGYKQSGLGREWGDYGIEEFLEVKSI 473 >5FHZ-A nrPDB Length = 529 Score = 159 bits (401), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 125/443 (28%), Positives = 208/443 (46%), Gaps = 22/443 (4%) Query: 4 ISDTVKRAREAFNSGKT-RSLQF--RIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 + V+ A+ AF G R L R + L L ++ + +++ D GK ++ Sbjct: 88 VDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAF 147 Query: 61 YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGAWNYPFN 119 + + LE T++ WA D+ KT T + + + EP+GV I WN+P Sbjct: 148 FID----LEGCIRTLRYFAGWA-DKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLL 202 Query: 120 LTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLK 178 + + + A+ GN ++LKP+E + A L +LI + + +V G P + Sbjct: 203 MLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAIS 262 Query: 179 E--RFDHIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDCDLDVACRRIAWG 235 + + I +TGST VGK+V AA++ +L VTLELGGK+PC V D DLD+A G Sbjct: 263 SHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQG 322 Query: 236 KFMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKDFYGEDAKQSRDYGRIINDRHFQRV 294 F N GQ C A + + + ++ V + ++ + K G+ + G I+ + F ++ Sbjct: 323 VFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKI 382 Query: 295 KGLIDNQKV------AHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSL 348 LI++ K G + +I PT+ +V + +EEIFGPV PI+ +S+ Sbjct: 383 LELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSI 442 Query: 349 EEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNS 408 EE I+ N + L VF+ N K+ + SG V N + PFGG S Sbjct: 443 EEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWIN--CYNALYAQAPFGGFKMS 500 Query: 409 GMGAYHGKKSFETFSHRRSCLVK 431 G G G+ + ++ ++ +K Sbjct: 501 GNGRELGEYALAEYTEVKTVTIK 523 >5AC0-A nrPDB Length = 501 Score = 158 bits (400), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 129/448 (28%), Positives = 209/448 (46%), Gaps = 32/448 (7%) Query: 4 ISDTVKRAREAFNSG---KTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 + VK AR+AF G +T R + L L +I + ++ A + GK +Y Sbjct: 60 VDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLIERDRLLLATMEAMNGGKLFSNAY 119 Query: 61 YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDD---LYIHSEPLGVVLVIGAWNYP 117 ++ ++ T++ WA+ + R D Y SEP+GV I WN+P Sbjct: 120 LMDLGGCIK----TLRYCAGWADK---IQGRTIPMDGNFFTYTRSEPVGVCGQIIPWNFP 172 Query: 118 FNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTEL 176 + + + A++ GN V++KP+E + A + +LI + + +V G P Sbjct: 173 LLMFLWKIGPALSCGNTVVVKPAEQTPLTALHMGSLIKEAGFPPGVVNIVPGYGPTAGAA 232 Query: 177 LKERFD--HIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDCDLDVACRRIA 233 + D + +TGST VGK++ AA K +L V+LELGGKSPC V D DLD A Sbjct: 233 ISSHMDVDKVAFTGSTEVGKLIKEAAGKSNLKRVSLELGGKSPCIVFADADLDNAVEFAH 292 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKDFYGEDAKQSRDYGRIINDRHFQ 292 G F + GQ C+A + + SI ++ V + ++++ K G G I+ ++ Sbjct: 293 QGVFYHQGQCCIAASRLFVEESIYDEFVRRSVERAKKYVLGNPLTPGVSQGPQIDKEQYE 352 Query: 293 RVKGLIDNQKV------AHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVR 346 ++ LI++ K GG W +I PT+ DV + +EEIFGPV I+ + Sbjct: 353 KILDLIESGKKEGAKLECGGGPWGNKGYFIQPTVFSDVTDDMRIAKEEIFGPVQQIMKFK 412 Query: 347 SLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETS---SGGVTANDVIVHITVPTLPFG 403 SL++ I+ N L+ +F+N+ I K I +S SG V N + PFG Sbjct: 413 SLDDVIKRANNTFYGLSAGIFTND---IDKAITVSSALQSGTVWVN--CYSVVSAQCPFG 467 Query: 404 GVGNSGMGAYHGKKSFETFSHRRSCLVK 431 G SG G G+ F ++ ++ +K Sbjct: 468 GFKMSGNGRELGEYGFHEYTEVKTVTIK 495 >5AC2-A nrPDB Length = 501 Score = 157 bits (396), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 132/452 (29%), Positives = 213/452 (47%), Gaps = 40/452 (8%) Query: 4 ISDTVKRAREAFNSG---------KTRSLQFRIQQLEALQRMINENLKSISGALASDLGK 54 + VK AR+AF G + L +++ L R++ ++S++G GK Sbjct: 60 VDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNG------GK 113 Query: 55 NEWTSYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGA 113 +Y ++A ++ T++ WA D+ +T + Y EP+GV I Sbjct: 114 LYSNAYLNDLAGCIK----TLRYCAGWA-DKIQGRTIPIDGNFFTYTRHEPIGVCGQIIP 168 Query: 114 WNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPE 172 WN+P + I + A++ GN V++KP+E + A +A+LI + + +V G P Sbjct: 169 WNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPT 228 Query: 173 TTELLKERFD--HIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDCDLDVAC 229 + D + +TGST VGK++ AA K +L VTLELGGKSPC V D DLD A Sbjct: 229 AGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAV 288 Query: 230 RRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKDFYGEDAKQSRDYGRIIND 288 G F + GQ C+A I + SI ++ V + ++++ K G G I+ Sbjct: 289 EFAHHGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDK 348 Query: 289 RHFQRVKGLIDNQKV------AHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPI 342 + ++ LI++ K GG W ++ PT+ +V + + +EEIFGPV I Sbjct: 349 EQYDKILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQI 408 Query: 343 VCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVH---ITVPT 399 + +SL++ I+ N L+ VF+ K I K I T S + A V V+ + Sbjct: 409 MKFKSLDDVIKRANNTFYGLSAGVFT---KDIDKAI--TISSALQAGTVWVNCYGVVSAQ 463 Query: 400 LPFGGVGNSGMGAYHGKKSFETFSHRRSCLVK 431 PFGG SG G G+ F ++ ++ VK Sbjct: 464 CPFGGFKMSGNGRELGEYGFHEYTEVKTVTVK 495 >4PXL-B nrPDB Length = 517 Score = 156 bits (395), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 134/444 (30%), Positives = 205/444 (46%), Gaps = 26/444 (5%) Query: 8 VKRAREAFNSGKTRSLQF--RIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEV- 64 VK AREAF++G + R + L +I+E+++ ++ D GK ++ Sbjct: 80 VKAAREAFDNGPWPRMTGYERGRILHRFADLIDEHVEELAALDTVDAGKLFAVGKARDIP 139 Query: 65 --AHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTI 122 AH+L + A+ A + Q+ Y EP+GVV I WNYP + Sbjct: 140 GAAHLL-------RYYAGAADKVHGATLKMAQRMHGYTLKEPVGVVGHIVPWNYPTTMFF 192 Query: 123 QPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKERF 181 + A+AAG AV++KP+E + A A L + + + VV G P + Sbjct: 193 FKVGPALAAGCAVVVKPAEQTPLSALFYAHLAREAGVPAGVLNVVPGFGPTAGAAVAAHM 252 Query: 182 D--HIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFM 238 D + +TGST VG++VM AAA+ +L PV+LELGGKSP V D DLD+A + + + Sbjct: 253 DVDKVSFTGSTEVGRLVMRAAAESNLKPVSLELGGKSPVIVFDDADLDMAVNLVNFATYT 312 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKK-SLKDFYGEDAKQSRDYGRIINDRHFQRVKGL 297 N G+ CVA I I ++ V+K + + K G+ S G ++ +++V Sbjct: 313 NKGEICVAGTRIYVQEGIYDEFVKKAAELASKSVVGDPFNPSVSQGPQVDKDQYEKVLRY 372 Query: 298 IDNQK------VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEA 351 ID K V G YI PTI DV + Q+EIFGPVM ++ +++EE Sbjct: 373 IDIGKREGATLVTGGKPCGDKGYYIEPTIFTDVKDDMTIAQDEIFGPVMALMKFKTVEEV 432 Query: 352 IQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMG 411 IQ N LA + + N V + +G + N P PFGG SG G Sbjct: 433 IQKANNTRYGLAAGIVTKNIDVANTVSRSIRAGAIWINCYFAFD--PDAPFGGYKMSGFG 490 Query: 412 AYHGKKSFETFSHRRSCLVKSLLN 435 G + + + ++ +V L N Sbjct: 491 KDMGMDALDKYLQTKT-VVTPLYN 513 >4V3F-A nrPDB Length = 497 Score = 155 bits (392), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 132/438 (30%), Positives = 201/438 (45%), Gaps = 35/438 (7%) Query: 8 VKRAREAF--NSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGK--NEWTSYYEE 63 V AR AF N+ S R L A+ I E D GK +E ++ Sbjct: 51 VVAARRAFRRNNWSATSGAHRATYLRAIAAKITEKKDHFVKLETIDSGKPFDEAVLDIDD 110 Query: 64 VAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQ 123 VA E + L D + PV T ++ ++ +PLGVV +I WNYP + Sbjct: 111 VASCFEYFAGQAEAL-DGKQKAPV--TLPMERFKSHVLRQPLGVVGLISPWNYPLLMATW 167 Query: 124 PMVGAVAAGNAVILKPSEVS-------GHMADLLATLIPQYMDQNLYLVVKGGVPETTEL 176 + A+AAG +LKPSE++ G + + + L P ++ L G P + Sbjct: 168 KIAPALAAGCTAVLKPSELASVTCLEFGEVCNEVG-LPPGVLNILTGLGPDAGAPLVSH- 225 Query: 177 LKERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGK 236 D I +TGS+A G VMA+AA+ + PVTLELGGKSP V +D D+D +G Sbjct: 226 --PDVDKIAFTGSSATGSKVMASAAQLVKPVTLELGGKSPIVVFEDVDIDKVVEWTIFGC 283 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDA-KQSRDYGRIINDRHFQRVK 295 F +GQ C A +L SI + V+KL K K+ D ++ G +I+ + ++ Sbjct: 284 FWTNGQICSATSRLLVHESIAAEFVDKLVKWTKNIKISDPFEEGCRLGPVISKGQYDKIM 343 Query: 296 GLIDNQK-----VAHGGTWDQSSR---YIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRS 347 I K + +GG+ + + YI PTI+ D+ + +EE+FGPV+ + S Sbjct: 344 KFISTAKSEGATILYGGSRPEHLKKGYYIEPTIVTDISTSMQIWKEEVFGPVLCVKTFSS 403 Query: 348 LEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTL---PFGG 404 +EAI N E LA VFSN+ + +++ G V N + P P+GG Sbjct: 404 EDEAIALANDTEYGLAAAVFSNDLERCERITKALEVGAVWVN-----CSQPCFVQAPWGG 458 Query: 405 VGNSGMGAYHGKKSFETF 422 + SG G G+ + + Sbjct: 459 IKRSGFGRELGEWGIQNY 476 >3B4W-A nrPDB Length = 495 Score = 154 bits (388), Expect = 9e-38, Method: Compositional matrix adjust. Identities = 112/354 (31%), Positives = 177/354 (50%), Gaps = 16/354 (4%) Query: 89 KTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMAD 148 +TR + EP+GVV I AWN P L + + A+ AG ++LKP+ + A+ Sbjct: 131 ETRTGSYGQSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVLKPAAETPLTAN 190 Query: 149 LLATLIPQY-MDQNLYLVVKGGVPETTELLKER--FDHIMYTGSTAVGKIVMAAAAKHLT 205 LA + + + + + VV GG+ ET + L D +TGS+AVG+ V AA+ L Sbjct: 191 ALAEVFAEVGLPEGVLSVVPGGI-ETGQALTSNPDIDMFTFTGSSAVGREVGRRAAEMLK 249 Query: 206 PVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLK 265 P TLELGGKS + +D DL A + + MN+GQ CV IL S ++IV + Sbjct: 250 PCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQGCVNQTRILAPRSRYDEIVAAVT 309 Query: 266 KSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGLI-----DNQKVAHGGTWDQ---SSRYI 316 + G + + G +I+++ RV+G I + ++ GG + + +I Sbjct: 310 NFVTALPVGPPSDPAAQIGPLISEKQRTRVEGYIAKGIEEGARLVCGGGRPEGLDNGFFI 369 Query: 317 APTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKK 376 PT+ DVD + + QEEIFGPV+ I+ + E+AI N LA V++ + K Sbjct: 370 QPTVFADVDNKMTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAGSVWTTDVPKGIK 429 Query: 377 MIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLV 430 + + +G N + P PFGG NSG+G +G + E F+ ++S L+ Sbjct: 430 ISQQIRTGTYGIN---WYAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQKSVLL 480 >1O9J-A nrPDB Length = 501 Score = 152 bits (384), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 134/449 (29%), Positives = 209/449 (46%), Gaps = 34/449 (7%) Query: 4 ISDTVKRAREAFNSG---KTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 + VK AREAF G +T R Q + L +I + ++ + + GK ++Y Sbjct: 60 VDKAVKAAREAFQMGSPWRTMDASERGQLIYKLADLIERDRLLLATLESINAGKVFASAY 119 Query: 61 YEEVAHVLEELDTTIKEL---PDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGAWNY 116 L +LD IK L WA D+ +T + Y EP+GV +I WN Sbjct: 120 -------LMDLDYCIKALRYCAGWA-DKIQGRTIPVDGEFFSYTRHEPIGVCGLIFPWNA 171 Query: 117 PFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTE 175 P L + A+ GN VI+KP+E + A +A+LI + + +V G P Sbjct: 172 PMILLACKIGPALCCGNTVIVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGA 231 Query: 176 LLKERFD--HIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDCDLDVACRRI 232 + D + +TGST VGK++ AAAK +L VTLELG K+PC V D DLD A Sbjct: 232 AISSHMDVDKVAFTGSTEVGKMIQEAAAKSNLKRVTLELGAKNPCIVFADADLDSAVEFA 291 Query: 233 AWGKFMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKDFYGEDAKQSRDYGRIINDRHF 291 G F N GQ+C+A + + +I ++ V++ ++++ K +G ++G IN Sbjct: 292 HQGVFTNQGQSCIAASKLFVEEAIYDEFVQRSVERAKKYVFGNPLTPGVNHGPQINKAQH 351 Query: 292 QRVKGLIDNQKV------AHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCV 345 ++ LI++ K GG W +I PT+ +V + +EEIFGPV I+ Sbjct: 352 NKIMELIESGKKEGAKLECGGGPWGNKGYFIQPTVFSNVTDDMRIAKEEIFGPVQQIMKF 411 Query: 346 RSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPT---LPF 402 +SL+E I+ N L VF+ K + K + T S + A V V+ + P Sbjct: 412 KSLDEVIKRANNTYYGLVAGVFT---KDLDKAV--TVSSALQAGTVWVNCYLAASAQSPA 466 Query: 403 GGVGNSGMGAYHGKKSFETFSHRRSCLVK 431 GG SG G G+ ++ ++ +K Sbjct: 467 GGFKMSGHGREMGEYGIHEYTEVKTVTMK 495 >4I8P-A nrPDB Length = 520 Score = 150 bits (380), Expect = 8e-37, Method: Compositional matrix adjust. Identities = 115/415 (27%), Positives = 194/415 (46%), Gaps = 27/415 (6%) Query: 26 RIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEELDTTIKELPDWAE-- 83 R + L A+ + E ++ A D GK Y+E A ++++ + D AE Sbjct: 91 RAKYLRAIAAKVIERKPELAKLEALDCGKP-----YDEAAWDMDDVAGCFEYFADQAEAL 145 Query: 84 ----DEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKP 139 + PV+ +T + ++ EP+GVV +I WNYP + + A+AAG +LKP Sbjct: 146 DKRQNSPVSLPMETFK--CHLRREPIGVVGLITPWNYPLLMATWKIAPALAAGCTAVLKP 203 Query: 140 SEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKER--FDHIMYTGSTAVGKIV 196 SE++ LA + + + + +V G P+ L D + +TGS GK + Sbjct: 204 SELASVTCLELADICKEVGLPSGVLNIVTGLGPDAGAPLSAHPDVDKVAFTGSFETGKKI 263 Query: 197 MAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSI 256 MA+AA + PVTLELGGKSP V D D+D A +G F +GQ C A +L I Sbjct: 264 MASAAPMVKPVTLELGGKSPIVVFDDVDIDKAVEWTLFGCFWTNGQICSATSRLLIHTKI 323 Query: 257 QNQIVEKLKKSLKDFYGEDA-KQSRDYGRIINDRHFQRVKGLIDNQK-----VAHGGTWD 310 + E++ K+ D ++ G ++++ ++++K I N K + GG Sbjct: 324 AKKFNERMVAWAKNIKVSDPLEEGCRLGPVVSEGQYEKIKKFISNAKSQGATILTGGVRP 383 Query: 311 ---QSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVF 367 + +I PTI+ D+ + +EE+FGPV+ + + +EAI+ N + LA V Sbjct: 384 AHLEKGFFIEPTIITDITTSMEIWREEVFGPVLCVKEFSTEDEAIELANDTQYGLAGAVI 443 Query: 368 SNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETF 422 S + + +++ E +G + N P+GG SG G G+ + + Sbjct: 444 SGDRERCQRLSEEIDAGCIWVN--CSQPCFCQAPWGGNKRSGFGRELGEGGIDNY 496 >4CAZ-A nrPDB Length = 490 Score = 150 bits (380), Expect = 8e-37, Method: Compositional matrix adjust. Identities = 110/350 (31%), Positives = 171/350 (48%), Gaps = 19/350 (5%) Query: 98 LYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY 157 +Y EPLGVV IGAWNYP + + A+AAGNA+I KPSEV+ A LA + + Sbjct: 136 VYTRREPLGVVAGIGAWNYPVQIALWKSAPALAAGNAMIFKPSEVTPLTALKLAEIYTEA 195 Query: 158 -MDQNLYLVVKGGVPETTELLKER--FDHIMYTGSTAVGKIVMA-AAAKHLTPVTLELGG 213 + ++ V+ G E + L E + I +TG T+ GK VMA A++ L VT+ELGG Sbjct: 196 GVPDGVFNVLTGSGREVGQWLTEHPLIEKISFTGGTSTGKKVMASASSSSLKEVTMELGG 255 Query: 214 KSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKDFY 272 KSP + D DLD A F +SGQ C + S Q + K L++ + Sbjct: 256 KSPLIIFPDADLDRAADIAVMANFFSSGQVCTNGTRVFIHRSQQARFEAKVLERVQRIRL 315 Query: 273 GEDAKQSRDYGRIINDRHFQRVKGLIDNQKVAHG-----------GTWDQSSRYIAPTIL 321 G+ ++ ++G +++ H + V G I++ K G + + + Y+APT+ Sbjct: 316 GDPQDENTNFGPLVSFPHMESVLGYIESGKAQKARLLCGGERVTDGAFGKGA-YVAPTVF 374 Query: 322 VDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAET 381 D +++EEIFGPVM I+ +EAI+ N E LA V + + + I Sbjct: 375 TDCRDDMTIVREEIFGPVMSILVYDDEDEAIRRANDTEYGLAAGVVTQDLARAHRAIHRL 434 Query: 382 SSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVK 431 +G N + +P GG SG+G +G + ++ +S V+ Sbjct: 435 EAGICWIN--TWGESPAEMPVGGYKQSGVGRENGLTTLAHYTRIKSVQVE 482 >4O5H-A nrPDB Length = 511 Score = 150 bits (379), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 108/346 (31%), Positives = 168/346 (48%), Gaps = 18/346 (5%) Query: 99 YIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLI--PQ 156 Y EP+GVV I WN+P + + A+A G V+LKP+E + A L LI Sbjct: 169 YTRKEPVGVVGAIIPWNFPLLMAAWKIAPALATGCTVVLKPAEDTPLSALRLGELIQAAG 228 Query: 157 YMDQNLYLVVKGGVPETTELLKE-RFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKS 215 + D + +V G L ++ R D I +TGST GK + AA ++T ++LELGGKS Sbjct: 229 FPDGVVNIVTGYGHTAGAALSRDPRIDKIAFTGSTQTGKTIGHAALDNMTRMSLELGGKS 288 Query: 216 PCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKK---SLKDFY 272 P V D DLD A + +A F N GQ C A + + ++E++ K SLK Sbjct: 289 PVIVLPDVDLDKAAQGVANAIFFNQGQVCTAGSRAYIHSKVFDGVIERVAKIAASLKIGP 348 Query: 273 GEDAKQSRDYGRIINDRHFQRVKGLIDNQKVAHGGTW------DQSSRYIAPTILVDVDP 326 G D + G +++ + +RV G ID+ D ++ PT+LVD Sbjct: 349 GMD--PATQIGPLVSAKQRERVCGYIDSGFGEGARAAAGGRAIDGPGFFVEPTVLVDTTQ 406 Query: 327 QSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGV 386 V++EEIFGPV+ + ++ A+Q N L ++SN+ I K++ ++G V Sbjct: 407 AMRVVREEIFGPVLVAMPFDDVDTAVQLANDTPYGLGASIWSNDLSAIHKLVPRIAAGTV 466 Query: 387 TANDVIVHITVP-TLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVK 431 N H + LPFGG+ SG G G+ + ++ +S ++ Sbjct: 467 WVN---CHSLLDNALPFGGMKQSGFGRELGRAVIDQYTESKSVMMN 509 >4YWE-A nrPDB Length = 487 Score = 149 bits (376), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 108/341 (31%), Positives = 163/341 (47%), Gaps = 13/341 (3%) Query: 103 EPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQN 161 EP GV I WNYP + + + A+AAGNA ++KP+E + +A L + + Sbjct: 146 EPHGVTGHIVPWNYPMQIFGRSVGAALAAGNACVVKPAEDACLSVLRVAELAAEAGLPAG 205 Query: 162 LYLVVKGGVPETTELLKER--FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYV 219 +V G E L DHI +TGS A GK+V AA++ PVTLELGGKSP V Sbjct: 206 ALNIVTGYGHEAGAALARHPGIDHISFTGSPATGKLVTQMAAENHVPVTLELGGKSPQIV 265 Query: 220 DKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQS 279 D DLD A + N GQTC A +L + ++ +VE+L + ++ Sbjct: 266 FADADLDAALPVLVSAIVQNGGQTCSAGSRVLIERAVYEPLVERLATAFNGLRVGPSRAD 325 Query: 280 RDYGRIINDRHFQRVKGLIDNQK------VAHG---GTWDQSSRYIAPTILVDVDPQSPV 330 D G +IN + QRV + + + AHG +S Y AP +L DV P + Sbjct: 326 LDCGPLINAKQQQRVWDFLSDAQHDGIPMAAHGQVVADAPESGFYQAPALLRDVPPSHRL 385 Query: 331 MQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTAND 390 QEE+FGPV+ + +EA+ N L +++ + ++ +G V N+ Sbjct: 386 AQEEVFGPVLAAMRFVDEDEAVALANGTPYGLVAGIWTRDGARQMRLARRLRAGQVFINN 445 Query: 391 VIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVK 431 V LPFGGVG+SG G G ++ F+ ++ ++ Sbjct: 446 YGAGGGV-ELPFGGVGHSGHGREKGFEALYGFTALKTIAIR 485 >3IWK-A nrPDB Length = 503 Score = 149 bits (376), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 135/468 (28%), Positives = 212/468 (45%), Gaps = 45/468 (9%) Query: 6 DTVKRA--REAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGK--------- 54 D KRA R+ S R + L A+ I E + + D GK Sbjct: 52 DAAKRAISRKNGRDWSAASGSLRARYLRAIAAKIKEKKDELGKLESIDCGKPLEEALADL 111 Query: 55 NEWTSYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAW 114 ++ + +E A + EELD+ K P++ T + YI EP+GVV +I W Sbjct: 112 DDVVACFEYYAGLAEELDSKQKA--------PISLPMDTFKS--YILKEPIGVVALITPW 161 Query: 115 NYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPET 173 NYPF + + A+AAG A ILKPSE++ L + + + + + +V G E Sbjct: 162 NYPFLMATWKIAPALAAGCAAILKPSELASVTCLELGEICKEVGLPRGVLNIVTGLGHEA 221 Query: 174 TELLKER--FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRR 231 L D I +TGS+A G +M AA+ + PV+LELGGKSP V +D DLD Sbjct: 222 GASLASHPDVDKISFTGSSATGSKIMTTAAQLVKPVSLELGGKSPIVVFEDVDLDKVAEW 281 Query: 232 IAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDA-KQSRDYGRIINDRH 290 +G F +GQ C A ++ SI + V+KL K ++ D ++ G I+++ Sbjct: 282 TVFGCFFTNGQICSATSRLIVHESIAVEFVDKLVKWAENIKISDPLEEGCRLGPIVSEAQ 341 Query: 291 FQRVKGLIDNQKVAHGGTWDQSSR---------YIAPTILVDVDPQSPVMQEEIFGPVMP 341 +++V I + K + G T R ++ PTI+ DV + +EE+FGPV+ Sbjct: 342 YKKVLNCISSAK-SEGATILTGGRRPEHLKKGYFVEPTIITDVTTSMQIWREEVFGPVLA 400 Query: 342 IVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTL- 400 + + EEAI N L V SN+ + +++ S + A V ++ P+ Sbjct: 401 VKTFSTEEEAINLANDTHYGLGSAVMSNDLERCERL-----SKALQAGIVWINCAQPSFI 455 Query: 401 --PFGGVGNSGMGAYHGKKSFETFSHRRSCLVKSLLNEEAHKARYPPS 446 P+GG+ SG G G+ E + + V ++E PPS Sbjct: 456 QAPWGGIKRSGFGRELGEWGLENYLSVKQ--VTRYTSDEPWGWYQPPS 501 >2HG2-A nrPDB Length = 479 Score = 149 bits (375), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 110/367 (29%), Positives = 184/367 (50%), Gaps = 21/367 (5%) Query: 26 RIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEELDTTIKELPDWA--- 82 R L + I E IS + + GK + + E VA + +D + +WA Sbjct: 68 RASWLRKISAGIRERASEISALIVEEGGKIQQLAEVE-VAFTADYIDY----MAEWARRY 122 Query: 83 EDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEV 142 E E + R + ++ + LGV I WN+PF L + M A+ GN +++KPSE Sbjct: 123 EGEIIQSDRPGE--NILLFKRALGVTTGILPWNFPFFLIARKMAPALLTGNTIVIKPSEF 180 Query: 143 SGHMADLLATLIPQY-MDQNLY-LVVKGGVPETTELLKE-RFDHIMYTGSTAVGKIVMAA 199 + + A A ++ + + + ++ LV+ G EL + + TGS + G+ +MA Sbjct: 181 TPNNAIAFAKIVDEIGLPRGVFNLVLGRGETVGQELAGNPKVAMVSMTGSVSAGEKIMAT 240 Query: 200 AAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQ 259 AAK++T V LELGGK+P V D DL++A + I + +NSGQ C + + I +Q Sbjct: 241 AAKNITKVCLELGGKAPAIVMDDADLELAVKAIVDSRVINSGQVCNCAERVYVQKGIYDQ 300 Query: 260 IVEKLKKSLKDF-YGEDAKQSR-DYGRIINDRHFQRV-----KGLIDNQKVAHGG-TWDQ 311 V +L ++++ +G A+++ G +IN +RV + + + +VA GG + Sbjct: 301 FVNRLGEAMQAVQFGNPAERNDIAMGPLINAAALERVEQKVARAVEEGARVAFGGKAVEG 360 Query: 312 SSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNE 371 Y PT+L+DV + +M EE FGPV+P+V +LE+AI N + L +++ N Sbjct: 361 KGYYYPPTLLLDVRQEMSIMHEETFGPVLPVVAFDTLEDAISMANDSDYGLTSSIYTQNL 420 Query: 372 KVIKKMI 378 V K I Sbjct: 421 NVAMKAI 427 >3VZ3-A nrPDB Length = 457 Score = 148 bits (374), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 114/444 (25%), Positives = 196/444 (44%), Gaps = 26/444 (5%) Query: 2 SSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 + I + +A+EAF + + S R Q LE ++ + + + +++GK ++ Sbjct: 26 AEIDAKLAKAQEAFQAYRRTSFSQRRQWLENAAAILERDTSKFAEIMTTEMGKTHQSAIA 85 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLT 121 E E+ + + E + +TQ + Y+ +PLG++L + WN+PF Sbjct: 86 EA-----EKSALVCRYYAEHGEQFLANEYTETQATESYVCYQPLGILLAVMPWNFPFWQV 140 Query: 122 IQPMVGAVAAGNAVILK-----PSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTEL 176 + A+ AGN +LK P A L A P+ + Q L + G + ++ Sbjct: 141 FRFAAPALMAGNVAVLKHASNVPQCALAVEAILEAAGFPEGVFQTLLI----GASQVEQV 196 Query: 177 LKE-RFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWG 235 +K+ R TGS G + + A + + P LELGG P V DLD A Sbjct: 197 IKDPRVKAATLTGSEPAGASLASLAGQEIKPTLLELGGSDPFVVFPSADLDEAVEVGTVA 256 Query: 236 KFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRV 294 + MN+GQ+ +A + +I + +EKL G+ D G + + Q + Sbjct: 257 RTMNNGQSAIAAKRFILHEAIAAEFLEKLHLKFASLKIGDPMAPETDIGPLATEGILQDI 316 Query: 295 KGLIDNQKVAHGGT-------WDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRS 347 +D Q VA G D++ + PTIL ++ P + ++QEE+F PV + V+ Sbjct: 317 SRQVD-QAVAAGAKILLGGRPLDRAGYFYPPTILTEIPPGAKILQEELFAPVAMVFTVKD 375 Query: 348 LEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGN 407 L++AI N L ++N+ ++ I E +G V N ++ + P LPFGG Sbjct: 376 LDQAIALANDIPFGLGASAWTNDPAEQQRFIQELDAGAVFINGMVK--SDPRLPFGGTKR 433 Query: 408 SGMGAYHGKKSFETFSHRRSCLVK 431 SG G G TF + ++ +K Sbjct: 434 SGYGRELGLAGIRTFVNAKTVWLK 457 >4PZ2-A nrPDB Length = 534 Score = 147 bits (372), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 127/440 (28%), Positives = 200/440 (45%), Gaps = 24/440 (5%) Query: 7 TVKRAREAFNSGK--TRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEV 64 V+ AR AF+ G+ S R + + L ++ E+ ++ + D GK+ + +V Sbjct: 93 AVRAARAAFDHGEWPRMSGSERGRIMARLADLVEEHAGELAALESLDAGKHPAVTRAVDV 152 Query: 65 AHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQP 124 + L D E + Q Q L EPLGV VI WN+P + Sbjct: 153 GNAAGSL-RYFAGAADKIHGETLKMPGQFQGHTL---REPLGVAGVIIPWNFPSTMFAVK 208 Query: 125 MVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKERFD- 182 + A+AAG A+++KP+E + A LA L Q + + VV G P L D Sbjct: 209 VAPALAAGCALVVKPAEQTPLSALYLAQLAKQAGVPDGVINVVPGFGPTAGAALASHMDV 268 Query: 183 -HIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNS 240 + +TGST VG+++M A+A+ +L PV LELGGKSP V D DLD+A F N Sbjct: 269 DMVSFTGSTEVGRLIMKASAESNLKPVYLELGGKSPLIVFDDADLDMAVELAVGASFFNK 328 Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGED--AKQSRDYGRIINDRHFQRVKGLI 298 G+ CVA + + ++ E+L + ++ + D + D G ++ ++RV I Sbjct: 329 GEACVAASRVYVQERVYDRFEERLAERMRSWVVGDPFSDPRADQGPQVDKAQYERVLSYI 388 Query: 299 DNQKVAHGGTWDQSSR---------YIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLE 349 D+ K G T R YI PT+ +V + +EEIFGPVM ++ +++E Sbjct: 389 DHGK-REGATLLTGGRPCAPEGKGYYIEPTVFTNVKEDMIIAKEEIFGPVMCLMKFKTVE 447 Query: 350 EAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSG 409 EAI N L V + + V +++ +G V N + PFGG SG Sbjct: 448 EAIARANDTRYGLGAGVVTRDLDVANRVVRSVRAGVVWVNCYFAMGS--DCPFGGRKMSG 505 Query: 410 MGAYHGKKSFETFSHRRSCL 429 G G + + + +S + Sbjct: 506 FGKDEGMHALDKYLAVKSVV 525 >3U4J-A nrPDB Length = 528 Score = 147 bits (372), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 107/339 (31%), Positives = 172/339 (50%), Gaps = 13/339 (3%) Query: 103 EPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQN 161 EP+GVV +I WN+PF + + + A+ +G V+LKPSE + + LA L + + Sbjct: 160 EPVGVVGIITPWNFPFIIASERVPWAIGSGCTVVLKPSEFTSGTSIRLAELAREAGIPDG 219 Query: 162 LYLVVKGGVPETTELLKE--RFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYV 219 ++ VV G ++L E D + +TGS VG + AA+ + V LELGGK P V Sbjct: 220 VFNVVTGYGDPAGQVLAEDPNVDMVAFTGSVRVGTKLGEIAARTVKRVGLELGGKGPQIV 279 Query: 220 DKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKK-SLKDFYGEDAKQ 278 D DLD A IA+G + N+GQ C++ +L I++ ++E+L S K +G+ + Sbjct: 280 FADADLDAAADGIAYGVYHNAGQCCISGSRLLVQEGIRDALMERLLDISRKVAFGDPLNE 339 Query: 279 SRDYGRIINDRHFQRV-----KGLIDNQKVAHGG--TWDQSSRYIAPTILVDVDPQSPVM 331 G +I++ H ++V G+ ++ GG ++ Y APT+ V P + Sbjct: 340 RTKIGAMISEAHAEKVHSYVTAGITSGAELLLGGERIGREAGLYYAPTVFAGVTPDMSIA 399 Query: 332 QEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDV 391 +EEIFGPV+ + ++ +EA+ N E L+ V+S N + + I +G N V Sbjct: 400 REEIFGPVLSTLTFKTADEAVALANATEFGLSASVWSTNLETALQTIRRIRAGRCWINSV 459 Query: 392 IVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLV 430 I P LP GG SG+G G+ F+ +S + V Sbjct: 460 IDG--TPELPIGGYKKSGLGRELGRYGFDEYSQFKGVHV 496 >4GO4-A nrPDB Length = 495 Score = 147 bits (370), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 109/348 (31%), Positives = 164/348 (47%), Gaps = 21/348 (6%) Query: 99 YIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY- 157 Y+ +P+GVV I WN+P T M A+AAGN +++KPSE++ + L+ + Sbjct: 133 YVQRKPIGVVAQIVPWNFPLMFTSWKMGPALAAGNTIVIKPSEITPLSTLRIVELMTEVG 192 Query: 158 MDQNLYLVVKGGVPETTELLKERFD--HIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKS 215 + + VV G + L E D I +TGSTA G+ ++ A+ +L + LELGGK Sbjct: 193 FPKGVVNVVPGYGHTAGQALAEHLDVGKIAFTGSTATGRRIVEASKSNLKRIQLELGGKG 252 Query: 216 PCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEK---LKKSLKDFY 272 V +D +++ A AW F N GQ C+A ++ I +Q +E+ L KS++ Sbjct: 253 ANIVFEDANIEAAVNGAAWAIFHNQGQACIAGSRLILHKDIADQFLERFIALAKSIR--L 310 Query: 273 GEDAKQSRDYGRIINDRHFQRVKGLID-----NQKVAHGGTWDQ-----SSRYIAPTILV 322 G+ + G + + RV ID KV GG + Y+ PT+ V Sbjct: 311 GDPMDPETEMGPLTSALRRDRVLSYIDIAIEQGGKVLAGGKAPDDKALANGFYVEPTV-V 369 Query: 323 DVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETS 382 + PQ V QEE+FGP + +V S EEA+ N E L +++ N KM Sbjct: 370 EAKPQDRVCQEEVFGPFVTVVRFSSDEEALAIANNTEYGLGSGLWTQNLARAHKMAHAIH 429 Query: 383 SGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLV 430 +G N P PFGGVG SG G G ++ ++ RS V Sbjct: 430 AGMCWIN--CYKRVSPGSPFGGVGQSGYGREMGFEAIHDYTEARSVWV 475 >4H7N-A nrPDB Length = 474 Score = 146 bits (369), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 127/455 (27%), Positives = 218/455 (47%), Gaps = 47/455 (10%) Query: 4 ISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEE 63 ++ RAR A + + ++ RI L+ ++ I + ++ AL +D G+ Sbjct: 30 LAQQCNRARRAQSRWQELGVEGRITTLQQWKQAILSRREQLTEALVNDTGR--------- 80 Query: 64 VAHVLEELDTTIKELPDWAEDEP-VAKTRQTQQDDLYIHSE----PLGVVLVIGAWNYPF 118 ++ + E+D+ + + W P + +T +I + P +V VI WN+P Sbjct: 81 LSITVLEIDSFLASIDRWCGLAPELLQTSAKNTSIPFIALQQSLVPYPLVGVISPWNFPL 140 Query: 119 NLTIQPMVGAVAAGNAVILKPSEVSGH-MADLLATL--IPQYMDQNLYLVVKGGVPETTE 175 L++ + A+ AG AV++KPSE++ +A LL L +P+ D + + V+GG ET Sbjct: 141 TLSMIDTIPALLAGCAVVVKPSEIAPRFVAPLLMALNTVPELRD--VLIFVEGG-GETGA 197 Query: 176 LLKERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWG 235 L D + +TGS A G+ V AA+ P LELGGK P V + +L++A I WG Sbjct: 198 NLINYVDFVCFTGSVATGREVAETAARRFIPAYLELGGKDPAIVLESANLELATSAILWG 257 Query: 236 KFMNSGQTCVAPDYILCDPS----IQNQIVEKLKK-SLKDFYGEDAK----QSRDYGRII 286 +N+GQ+C++ + I S +Q++ K + L ED + II Sbjct: 258 AVVNTGQSCLSIERIYVAESKFEEFYHQLIAKAHRLQLAYPLVEDGAIGPIIAEKQAGII 317 Query: 287 NDRHFQRV-KGLIDN--QKVAH-GGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPI 342 ND V KG + + KV GG W + PT++ +V+ VM EE FGP+MP+ Sbjct: 318 NDHILDAVEKGAVIHCGGKVEELGGGW-----WCRPTVMTNVNHSMKVMTEETFGPIMPV 372 Query: 343 VCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITV----- 397 + +EEA+ N L+ VF+ +E K+ + ++G ++ ND + + Sbjct: 373 MPFPDVEEAVYLANDTIYGLSAAVFAGSEDEALKVARQLNAGAISINDAALTAMMHEGEK 432 Query: 398 PTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVKS 432 F G+G S +GA K+ F +++ L+K+ Sbjct: 433 NAFNFSGLGGSRVGAAGLKR----FLRKQAFLIKT 463 >5L13-A nrPDB Length = 517 Score = 146 bits (369), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 122/443 (27%), Positives = 197/443 (44%), Gaps = 22/443 (4%) Query: 4 ISDTVKRAREAFNSG---KTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 + VK AR AF G + R + L L +I + ++ D GK SY Sbjct: 76 VDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISY 135 Query: 61 YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGAWNYPFN 119 ++ VL+ ++ WA D+ KT D Y EP+GV I WN+P Sbjct: 136 LVDLDMVLK----CLRYYAGWA-DKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLL 190 Query: 120 LTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLK 178 + + A+A GN V++K +E + A +A LI + + +V G P + Sbjct: 191 MQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIA 250 Query: 179 --ERFDHIMYTGSTAVGKIV-MAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWG 235 E D + +TGST +G+++ +AA + +L VTLELGGKSP + D D+D A + + Sbjct: 251 SHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFA 310 Query: 236 KFMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKDFYGEDAKQSRDYGRIINDRHFQRV 294 F N GQ C A I ++ VE+ + ++ G + G +++ F+++ Sbjct: 311 LFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKI 370 Query: 295 KGLIDNQK------VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSL 348 G I+ K + GG +I PT+ DV + +EEIFGPVM I+ +++ Sbjct: 371 LGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTI 430 Query: 349 EEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNS 408 EE + N LA VF+ + + +G V N + PFGG S Sbjct: 431 EEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVN--CYDVFGAQSPFGGYKMS 488 Query: 409 GMGAYHGKKSFETFSHRRSCLVK 431 G G G+ + ++ ++ VK Sbjct: 489 GSGRELGEYGLQAYTEVKTVTVK 511 >5GT6-A nrPDB Length = 508 Score = 145 bits (367), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 124/440 (28%), Positives = 201/440 (45%), Gaps = 20/440 (4%) Query: 4 ISDTVKRAREAFNSGKTRSLQF--RIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 I VK AR AF SG + R + L +I E+ + ++ A D GK + Sbjct: 73 IDAAVKAARSAFESGPWAEMTTAERAHLIYKLADLIEEHREELAQLEALDNGKPYQVALD 132 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGAWNYPFNL 120 ++++ +E + W + + +T +D L Y EP+GVV I WN+P + Sbjct: 133 DDISATVENY----RYYAGWT-TKIIGQTIPISKDYLNYTRHEPVGVVGQIIPWNFPLVM 187 Query: 121 TIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYL-VVKGGVPETTELL-- 177 + M A+A G ++LKP+E + A L + N + V G PE + Sbjct: 188 SSWKMGAALATGCTIVLKPAEQTPLSLLYAAKLFKEAGFPNGVVNFVPGFGPEAGAAIVN 247 Query: 178 KERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKF 237 D + +TGST GK +M +A+ + VTLELGGKSP + +D DL+ A G Sbjct: 248 HHDIDKVAFTGSTVTGKYIMRQSAEMIKHVTLELGGKSPNIILEDADLEEAINGAFQGIM 307 Query: 238 MNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKG 296 N GQ C A + +V+ L K + G ++ + G +++ + +RV Sbjct: 308 YNHGQNCSAGSRVFVHRKHYETVVDALVKMANNVKLGAGMEKETEMGPLVSKKQQERVLN 367 Query: 297 LIDNQK-----VAHGGTWD-QSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEE 350 I+ K VA GG + ++ PT+ DV +++EEIFGPV+ ++ S EE Sbjct: 368 YIEQGKKEGATVAAGGERALEKGYFVKPTVFTDVTDDMTIVKEEIFGPVVVVLPFDSTEE 427 Query: 351 AIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGM 410 I+ N LA V++ N K ++ + +G V ND ++ PFGG SG+ Sbjct: 428 VIERANNSSYGLAAGVWTQNIKTGHQVANKLKAGTVWIND--YNLENAAAPFGGYKQSGI 485 Query: 411 GAYHGKKSFETFSHRRSCLV 430 G G + + ++ +S V Sbjct: 486 GRELGSYALDNYTEVKSVWV 505 >3K2W-A nrPDB Length = 497 Score = 145 bits (366), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 108/359 (30%), Positives = 165/359 (45%), Gaps = 32/359 (8%) Query: 94 QQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATL 153 Q + +YIH P GVV+ I AWN+P L + + A+ GN ++LKP++ + L + Sbjct: 138 QDEKIYIHKVPRGVVVGITAWNFPLALAGRKIGPALITGNTMVLKPTQETPLATTELGRI 197 Query: 154 IPQY-MDQNLYLVVKGGVPETTELLKER--FDHIMYTGSTAVGKIVMAAAAKHLTPVTLE 210 + + + V+ G + L E I TGST GK + +A+++TPV LE Sbjct: 198 AKEAGLPDGVLNVINGTGSVVGQTLCESPITKMITMTGSTVAGKQIYKTSAEYMTPVMLE 257 Query: 211 LGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEK---LKKS 267 LGGK+P V D DLD A WG+F N GQ C + + S+ ++ + K L K Sbjct: 258 LGGKAPMVVMDDADLDKAAEDALWGRFANCGQVCTCVERLYVHASVYDEFMAKFLPLVKG 317 Query: 268 LKDFYGEDAKQSRDYGRIINDRHFQRVKGLI-----DNQKVAHGGTWD-----QSSRYIA 317 LK G+ G N R + ++ VA GG + + Sbjct: 318 LK--VGDPMDADSQMGPKCNQREIDNIDHIVHEAIKQGATVATGGKTATVEGFEGGCWYE 375 Query: 318 PTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKM 377 PT+LVDV + V+ EE FGP++PIV V S+E+AI+F N L+ YV + + I + Sbjct: 376 PTVLVDVKQDNIVVHEETFGPILPIVKVSSMEQAIEFCNDSIYGLSAYVHTQSFANINQA 435 Query: 378 IAETSSGGVTANDVI------VHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLV 430 I++ G V N + H G SG G GK E + +++ + Sbjct: 436 ISDLEVGEVYINRGMGEQHQGFH--------NGWKQSGFGGEDGKFGLEQYLEKKTVYI 486 >1BPW-A nrPDB Length = 503 Score = 143 bits (361), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 107/349 (30%), Positives = 165/349 (47%), Gaps = 19/349 (5%) Query: 99 YIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY- 157 Y EPLGV I AWNYPF + A+A GNAV+ KPS ++ +LA + + Sbjct: 150 YTRREPLGVCAGILAWNYPFMIAAWKCAPALACGNAVVFKPSPMTPVTGVILAEIFHEAG 209 Query: 158 MDQNLYLVVKGGVPETTELL--KERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKS 215 + L VV+GG ET LL + +TGS GK VM +AK + VTLELGGKS Sbjct: 210 VPVGLVNVVQGGA-ETGSLLCHHPNVAKVSFTGSVPTGKKVMEMSAKTVKHVTLELGGKS 268 Query: 216 PCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGE 274 P + KDC+L+ A R F+ GQ C + I Q +E++ K K G+ Sbjct: 269 PLLIFKDCELENAVRGALMANFLTQGQVCTNGTRVFVQREIMPQFLEEVVKRTKAIVVGD 328 Query: 275 DAKQSRDYGRIINDRHFQRVKGLI-----DNQKVAHGGT-------WDQSSRYIAPTILV 322 G +I+ +V G + + +V GG ++ +++P +L Sbjct: 329 PLLTETRMGGLISKPQLDKVLGFVAQAKKEGARVLCGGEPLTPSDPKLKNGYFMSPCVLD 388 Query: 323 DVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETS 382 + ++EEIFGPVM ++ + EE +Q N LA VF+ + ++ A Sbjct: 389 NCRDDMTCVKEEIFGPVMSVLPFDTEEEVLQRANNTTFGLASGVFTRDISRAHRVAANLE 448 Query: 383 SGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVK 431 +G N I+ +PFGG SG G +G+ + + +S ++ +V+ Sbjct: 449 AGTCYIN--TYSISPVEVPFGGYKMSGFGRENGQATVDYYSQLKTVIVE 495 >1AG8-A nrPDB Length = 499 Score = 142 bits (359), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 123/445 (27%), Positives = 196/445 (44%), Gaps = 22/445 (4%) Query: 2 SSISDTVKRAREAFNSG---KTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWT 58 + + VK AR AF G + R + L L +I + ++ D GK Sbjct: 56 ADVDRAVKAARAAFQLGSPWRRMDASERGRLLNRLADLIERDRTYLAALETLDNGKPYII 115 Query: 59 SYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGAWNYP 117 SY ++ VL+ ++ WA D+ KT D Y EP+GV I WN+P Sbjct: 116 SYLVDLDMVLK----CLRYYAGWA-DKYHGKTIPIDGDYFSYTRHEPVGVCGQIIPWNFP 170 Query: 118 FNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTEL 176 + + A+A GN V++K +E + A +A LI + + V+ G P Sbjct: 171 LLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNVIPGFGPTAGAA 230 Query: 177 LK--ERFDHIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDCDLDVACRRIA 233 + E D + +TGST VG ++ AA K +L VTLE+GGKSP + D D+D A + Sbjct: 231 IASHEDVDKVAFTGSTEVGHLIQVAAGKSNLKRVTLEIGGKSPNIIMSDADMDWAVEQAH 290 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKDFYGEDAKQSRDYGRIINDRHFQ 292 + F N GQ C A I + VE+ + ++ G + G +++ F+ Sbjct: 291 FALFFNQGQCCCAGSRTFVQEDIYAEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFK 350 Query: 293 RVKGLIDNQK------VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVR 346 +V G I + K + GG +I PT+ D+ + +EEIFGPVM I+ + Sbjct: 351 KVLGYIKSGKEEGLKLLCGGGAAADRGYFIQPTVFGDLQDGMTIAKEEIFGPVMQILKFK 410 Query: 347 SLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVG 406 S+EE + N + LA VF+ + + +G V N + PFGG Sbjct: 411 SMEEVVGRANNSKYGLAAAVFTKDLDKANYLSQALQAGTVWVN--CYDVFGAQSPFGGYK 468 Query: 407 NSGMGAYHGKKSFETFSHRRSCLVK 431 SG G G+ + ++ ++ V+ Sbjct: 469 LSGSGRELGEYGLQAYTEVKTVTVR 493 >4I8Q-A nrPDB Length = 514 Score = 142 bits (358), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 134/434 (30%), Positives = 204/434 (47%), Gaps = 26/434 (5%) Query: 8 VKRAREAF---NSGKTRSLQFRIQQLEALQRMINENLKSISGALAS-DLGKNEWTSY--Y 61 V+ AR+A + G T Q R + L A+ + E KS+ L S D GK + S Sbjct: 67 VEAARKAIARDDWGSTTGAQ-RAKYLRAIAAKVLEK-KSVLATLESLDSGKTLYESAADM 124 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLT 121 ++VA E + E D PV + + Y+ EPLGVV +I WNYP + Sbjct: 125 DDVAGCFEYY-AGLAEALDSRRMTPVNLNSDSYKS--YVLREPLGVVGLITPWNYPLLMA 181 Query: 122 IQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKE- 179 I + A+AAG A ILKPSE++ L + + + ++ G PE L Sbjct: 182 IWKVAPALAAGCAAILKPSELASITCLELGEICREIGLPSGALNILTGLGPEAGGPLASH 241 Query: 180 -RFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCD-LDVACRRIAWGKF 237 D I +TGS G +M AAA+ + PV+L LGGKSP V D D LD+A +G F Sbjct: 242 PHVDKISFTGSGPTGSKIMTAAAQLVKPVSLALGGKSPIVVFDDIDNLDIAAEWTLFGIF 301 Query: 238 MNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDA-KQSRDYGRIINDRHFQRVKG 296 N+GQ C A ++ +I + +++L K K+ D ++ G +++ +++V Sbjct: 302 ANTGQVCSATSRLIVQENIASAFMDRLLKWTKNIKISDPLEEDCKLGPVVSAGQYEKVLK 361 Query: 297 LIDNQK-----VAHGGTWDQSSR---YIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSL 348 I N K + GG Q + Y+ PTI+ DV+ + +EE+FGPV+ + ++ Sbjct: 362 FISNAKSEGATILCGGERPQHLKKGYYVQPTIITDVNTSMEIWKEEVFGPVLCVKTFKTE 421 Query: 349 EEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNS 408 E+AI+ N + L V S + K ++ +G + N T LP+GG S Sbjct: 422 EQAIELANDTKYGLGAAVMSKDVKRCERFTKAFQTGIIWIN--CSQPTFNELPWGGKKRS 479 Query: 409 GMGAYHGKKSFETF 422 G G GK E F Sbjct: 480 GFGRDLGKWGLENF 493 >3RJL-A nrPDB Length = 538 Score = 142 bits (358), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 114/426 (26%), Positives = 195/426 (45%), Gaps = 25/426 (5%) Query: 8 VKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHV 67 ++ A +AF + + + R L + S L + GK W + A Sbjct: 80 IQAAAKAFETWRYTDPEERAAVLFRAVAKVRRKKHEFSALLVKEAGK-PWNEADADTAEA 138 Query: 68 LEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVG 127 ++ ++ +++ + A+ +PV +R+ +++ Y+++ P GV +VI WN+ F + V Sbjct: 139 IDFMEYYARQMIELAKGKPV-NSREGERNQ-YVYT-PTGVTVVIPPWNFLFAIMAGTTVA 195 Query: 128 AVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKERFDH--- 183 + GN V+LKP+ + +A ++ + + + + V G E + L DH Sbjct: 196 PIVTGNTVVLKPASAAPVIAAKFVEVLEESGLPKGVVNFVPGSGAEVGDYL---VDHPKT 252 Query: 184 --IMYTGSTAVGKIVMAAAAK------HLTPVTLELGGKSPCYVDKDCDLDVACRRIAWG 235 I +TGS VG + AAK HL V E+GGK VD+DCD+++A + I Sbjct: 253 SIITFTGSREVGTRIFERAAKVQPGQTHLKQVIAEMGGKDTVVVDEDCDIELAAQSIFTS 312 Query: 236 KFMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKDFYGEDAKQSRDYGRIINDRHFQRV 294 F +GQ C A + + ++++++ ++ + GE G +I+ F ++ Sbjct: 313 AFGFAGQKCSAGSRAVVHEKVYDEVLKRVIEITESKKVGEPDSADVYMGPVIDQASFNKI 372 Query: 295 KGLID----NQKVAHGGTWDQSSRY-IAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLE 349 I+ ++ GG D S Y I PTI D+DP++ +MQEEIFGPV+ V S + Sbjct: 373 MDYIEIGKEEGRLVSGGKGDDSKGYFIEPTIFADLDPKARLMQEEIFGPVVAFSKVSSFD 432 Query: 350 EAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSG 409 EA++ N E L V + N I + E G + N V PFGG SG Sbjct: 433 EALEVANNTEYGLTGAVITKNRDHINRAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSG 492 Query: 410 MGAYHG 415 + G Sbjct: 493 TDSKAG 498 >3IWJ-A nrPDB Length = 503 Score = 142 bits (357), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 123/441 (27%), Positives = 203/441 (46%), Gaps = 21/441 (4%) Query: 20 TRSLQFRIQQLEALQRMINENLKSISGALASDLGK--NEWTSYYEEVAHVLEELDTTIKE 77 T S R + L A+ + E ++ + D GK +E ++VA E ++ Sbjct: 68 TASGAVRARYLRAIAAKVTEKKPELAKLESIDCGKPLDEAAWDIDDVAGCFEYYADLAEK 127 Query: 78 LPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVIL 137 L D + PV+ T + ++ EP+GVV +I WNYP + + A+AAG A IL Sbjct: 128 L-DARQKAPVSLPMDTFKS--HVLREPIGVVGLITPWNYPMLMATWKVAPALAAGCAAIL 184 Query: 138 KPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKER--FDHIMYTGSTAVGK 194 KPSE++ L + + + + ++ G PE L D + +TGS+A G Sbjct: 185 KPSELASLTCLELGEICKEVGLPPGVLNILTGLGPEAGAPLATHPDVDKVAFTGSSATGS 244 Query: 195 IVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDP 254 +M AAA+ + PV+LELGGKSP V +D DLD A +G F +GQ C A ++ Sbjct: 245 KIMTAAAQLVKPVSLELGGKSPLVVFEDVDLDKAAEWAIFGCFWTNGQICSATSRLILHE 304 Query: 255 SIQNQIVEKLKKSLKDFYGEDA-KQSRDYGRIINDRHFQRVKGLIDNQKVAHGGTWDQSS 313 SI + + ++ K +K+ D ++ G ++++ ++++ + N K S Sbjct: 305 SIATEFLNRIVKWIKNIKISDPLEEGCRLGPVVSEGQYEKILKFVSNAKSEGATILTGGS 364 Query: 314 R--------YIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALY 365 R +I PTI+ DV + +EE+FGPV+ + + EEAI N L Sbjct: 365 RPEHLKKGFFIEPTIITDVTTNMQIWREEVFGPVLCVKTFSTEEEAIDLANDTVYGLGAA 424 Query: 366 VFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHR 425 V SN+ + +++ +G V N P+GGV SG G G+ + + Sbjct: 425 VISNDLERCERVTKAFKAGIVWVN--CSQPCFTQAPWGGVKRSGFGRELGEWGLDNYLSV 482 Query: 426 RSCLVKSLLNEEAHKARYPPS 446 + V ++EE PP+ Sbjct: 483 KQ--VTQYISEEPWGWYQPPA 501 >4O6R-A nrPDB Length = 496 Score = 142 bits (357), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 109/360 (30%), Positives = 164/360 (45%), Gaps = 20/360 (5%) Query: 99 YIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY- 157 Y+ P+GVV I WN+P T M A+AAGN V+LKPSE++ + L+ + Sbjct: 141 YVQRAPIGVVGQIVPWNFPLMFTSWKMGPALAAGNTVVLKPSEITPLSTLRIVELMAEVG 200 Query: 158 MDQNLYLVVKGGVPETTELLKER--FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKS 215 + +V G + L E I +TGSTA G+ ++ A+ +L V LELGGK Sbjct: 201 FPAGVVNIVPGYGHTAGQRLAEHPGVGKIAFTGSTATGRRIVEASQGNLKRVQLELGGKG 260 Query: 216 PCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEK---LKKSLKDFY 272 V D +LD A AW F N GQ C+A ++ I + +E+ L S++ Sbjct: 261 ANIVFDDANLDAAINGAAWAIFHNQGQACIAGSRLVLHERIADAFLERFVALASSIR--I 318 Query: 273 GEDAKQSRDYGRIINDRHFQRVKGLID-----NQKVAHGGTWDQ-----SSRYIAPTILV 322 G + + G + + +H RV +D +V GG+ Q + Y+ PTI+ Sbjct: 319 GNPLDPNTEMGPLTSKQHLDRVLSYVDVAREQGGRVLTGGSAPQDPALANGYYVRPTIVE 378 Query: 323 DVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETS 382 V QEE+FGP + ++ S +EA+ N E L +++N+ +M A Sbjct: 379 AKHATDRVAQEEVFGPFVTVLRFGSDDEALAIANATEYGLGSGLWTNDLSRAHRMAARID 438 Query: 383 SGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVKSLLNEEAHKAR 442 +G N P PFGGVG SG G G ++ ++ RS V N H R Sbjct: 439 AGMCWIN--CYKRVNPGSPFGGVGKSGYGREMGFEAMHDYTEARSVWVNVDGNVPPHFKR 496 >4LIH-A nrPDB Length = 504 Score = 141 bits (355), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 107/330 (32%), Positives = 161/330 (48%), Gaps = 14/330 (4%) Query: 114 WNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATL-IPQYMDQNLYLVVKG-GVP 171 WN+P + A+AAGN+V+LKPSE S A +A L + ++ VV G G P Sbjct: 175 WNFPILMAAWKFGPALAAGNSVVLKPSEKSPLTAIRVAQLAFEAGIPAGVFNVVPGAGEP 234 Query: 172 ETTELLKERFDHIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDC-DLDVAC 229 L D I +TGSTAVGK++M AA+ +L LELGGKSP V DC DLD A Sbjct: 235 GKLLALHRDVDCIAFTGSTAVGKLIMQYAAQSNLKRAWLELGGKSPNIVLPDCPDLDRAA 294 Query: 230 RRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFY-GEDAKQSRDYGRIIND 288 + A F N G+ C A +L I++ +EKL + + + G S G I++ Sbjct: 295 QTAAGAIFYNMGEMCTAGSRLLVHRDIKDAFIEKLVAAARAYVPGNPLDPSVSMGAIVDG 354 Query: 289 RHFQRVKGLID----NQKVAHGGT---WDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMP 341 +RV G I+ ++ GG + Y+ PT+ +V P + + +EEIFGPV+ Sbjct: 355 IQLERVLGYIEAGRGEGRLVTGGARVNAETGGFYVEPTVF-EVKPDAKIAREEIFGPVLS 413 Query: 342 IVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLP 401 ++ ++EA++ N E LA V+++N + +G V N P Sbjct: 414 VIVFDDVDEAVRIANDTEYGLAAAVWTSNLTTAHDVSRRLRAGTVWVN-CYDEGGDMNFP 472 Query: 402 FGGVGNSGMGAYHGKKSFETFSHRRSCLVK 431 FGG SG G + E ++ +S L++ Sbjct: 473 FGGYKQSGNGRDKSLHALEKYTELKSTLIR 502 >3QAN-A nrPDB Length = 538 Score = 140 bits (352), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 115/426 (26%), Positives = 186/426 (43%), Gaps = 25/426 (5%) Query: 8 VKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHV 67 ++ A EAF + + + + R L +I S L + GK W + A Sbjct: 80 IQSADEAFQTWRNVNPEERANILVKAAAIIRRRKHEFSAWLVHEAGK-PWKEADADTAEA 138 Query: 68 LEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVG 127 ++ L+ +++ + + + Q Y P+GV + I WN+ + + V Sbjct: 139 IDFLEYYARQMIELNRGKEILSRPGEQNRYFYT---PMGVTVTISPWNFALAIMVGTAVA 195 Query: 128 AVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPET-TELLKERFDH--- 183 + GN V+LKP+ + +A A + D L V VP + E+ DH Sbjct: 196 PIVTGNTVVLKPASTTPVVA---AKFVEVLEDAGLPKGVINYVPGSGAEVGDYLVDHPKT 252 Query: 184 --IMYTGSTAVGKIVMAAAA------KHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWG 235 I +TGS VG + AA HL V +E+GGK VD+D DLD+A I Sbjct: 253 SLITFTGSKDVGVRLYERAAVVRPGQNHLKRVIVEMGGKDTVVVDRDADLDLAAESILVS 312 Query: 236 KFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDY-GRIINDRHFQRV 294 F SGQ C A + + ++++EK K+ D +Y G +I+++ F+++ Sbjct: 313 AFGFSGQKCSAGSRAVIHKDVYDEVLEKTVALAKNLTVGDPTNRDNYMGPVIDEKAFEKI 372 Query: 295 KGLID----NQKVAHGGTWDQSSRY-IAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLE 349 I+ ++ GG D S+ + I PTI+ D+DP++ +MQEEIFGPV+ + Sbjct: 373 MSYIEIGKKEGRLMTGGEGDSSTGFFIQPTIIADLDPEAVIMQEEIFGPVVAFSKANDFD 432 Query: 350 EAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSG 409 A++ N E L V + N I++ E G + N V PFGG SG Sbjct: 433 HALEIANNTEYGLTGAVITRNRAHIEQAKREFHVGNLYFNRNCTGAIVGYHPFGGFKMSG 492 Query: 410 MGAYHG 415 + G Sbjct: 493 TDSKAG 498 >4X2Q-A nrPDB Length = 504 Score = 139 bits (350), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 121/448 (27%), Positives = 206/448 (45%), Gaps = 28/448 (6%) Query: 2 SSISDTVKRAREAFNSG---KTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWT 58 + I V+ AR AF+ G + R + L+ L ++ + ++ + + GK Sbjct: 61 ADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQ 120 Query: 59 SYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGAWNYP 117 ++Y ++ V++ T + WA D+ T D + EP+GV I WN+P Sbjct: 121 AFYVDLQGVIK----TFRYYAGWA-DKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFP 175 Query: 118 FNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTEL 176 + + A+ GN V++KP+E + A + LI + + ++ G P Sbjct: 176 LLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAA 235 Query: 177 LKERF--DHIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDCDLDVACRRIA 233 + D I +TGST VGK++ AA + +L VTLELGGKSP + D DLD A + Sbjct: 236 IASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAH 295 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKDFYGEDAKQSRDYGRIINDRHFQ 292 G F N GQ C A I + SI + V + ++++ + G + + G I+ + + Sbjct: 296 QGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYN 355 Query: 293 RV-----KGLIDNQKVAHGGT-WDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVR 346 ++ G+ + K+ GG + +I PT+ +V + +EEIFGPV I+ + Sbjct: 356 KILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFK 415 Query: 347 SLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHI---TVPTLPFG 403 +++E I+ N + L VF+N+ I K + T S + A V ++ PFG Sbjct: 416 TMDEVIERANNSDFGLVAAVFTND---INKAL--TVSSAMQAGTVWINCYNALNAQSPFG 470 Query: 404 GVGNSGMGAYHGKKSFETFSHRRSCLVK 431 G SG G G+ +S ++ VK Sbjct: 471 GFKMSGNGREMGEFGLREYSEVKTVTVK 498 >4MPY-A nrPDB Length = 520 Score = 139 bits (349), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 119/445 (26%), Positives = 201/445 (45%), Gaps = 36/445 (8%) Query: 11 AREAFNSGK--TRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY--YEEVAH 66 AR AF SG+ + + R +++ A+ I E+ ++++ D GK SY +++ + Sbjct: 79 ARRAFESGEWSQETAETRGKKVRAIADKIKEHREALARLETLDTGKTLEESYADMDDIHN 138 Query: 67 VLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMV 126 V + D P+ T I EP+GVV I WNYP + Sbjct: 139 VFMYFAGLADKDGGEMIDSPIPDTESK------IVKEPVGVVTQITPWNYPLLQASWKIA 192 Query: 127 GAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQ--------NLYLVVKGGVPETTELLK 178 A+A G ++++KPSE++ L + + M++ NL L V + K Sbjct: 193 PALATGCSLVMKPSEIT----PLTTIRVFELMEEVGFPKGTINLILGAGSEVGDVMSGHK 248 Query: 179 ERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFM 238 E D + +TG GK +M AA ++T + LELGGK+P + D D ++A + G + Sbjct: 249 E-VDLVSFTGGIETGKHIMKNAANNVTNIALELGGKNPNIIFDDADFELAVDQALNGGYF 307 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGL 297 ++GQ C A IL SI+++ + L +K G + G +I+ H +++ Sbjct: 308 HAGQVCSAGSRILVQNSIKDKFEQALIDRVKKIKLGNGFDADTEMGPVISTEHRNKIESY 367 Query: 298 IDNQK-----VAHGGTWD-----QSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRS 347 +D K +A GG + + PT++ + D ++QEE+FGPV+ + + Sbjct: 368 MDVAKAEGATIAVGGKRPDRDDLKDGLFFEPTVITNCDTSMRIVQEEVFGPVVTVEGFET 427 Query: 348 LEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGN 407 +EAIQ N LA VFS + +++ + G V ND H P+GG Sbjct: 428 EQEAIQLANDSIYGLAGAVFSKDIGKAQRVANKLKLGTVWIND--FHPYFAQAPWGGYKQ 485 Query: 408 SGMGAYHGKKSFETFSHRRSCLVKS 432 SG+G GK+ E + + L + Sbjct: 486 SGIGRELGKEGLEEYLVSKHILTNT 510 >5X5U-A nrPDB Length = 505 Score = 139 bits (349), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 98/341 (28%), Positives = 157/341 (46%), Gaps = 12/341 (3%) Query: 103 EPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILK-PSEVSGHMADLLATLIPQYMDQN 161 EP+G V WN+P N ++ + A+A G + ++K P E A LL + + Sbjct: 167 EPVGPVAAFTPWNFPVNQVVRKLSAALATGCSFLVKAPEETPASPAALLRAFVDAGVPAG 226 Query: 162 LYLVVKGGVPETTELLKER--FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYV 219 + +V G E + L + +TGST VGK + + A H+ T+ELGG +P V Sbjct: 227 VIGLVYGDPAEISSYLIPHPVIRKVTFTGSTPVGKQLASLAGLHMKRATMELGGHAPVIV 286 Query: 220 DKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQ 278 +D D+ +A + KF N+GQ C++P L SI+++ L K + G ++ Sbjct: 287 AEDADVALAVKAAGGAKFRNAGQVCISPTRFLVHNSIRDEFTRALVKHAEGLKVGNGLEE 346 Query: 279 SRDYGRIINDRHFQRVKGLIDNQK-----VAHGGTWDQS-SRYIAPTILVDVDPQSPVMQ 332 G + N R + +IDN + + GG S + APT++ +V + V Sbjct: 347 GTTLGALANPRRLTAMASVIDNARKVGASIETGGERIGSEGNFFAPTVIANVPLDADVFN 406 Query: 333 EEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVI 392 E FGPV I LEEAI N+ LA Y F+ + + + G + N Sbjct: 407 NEPFGPVAAIRGFDKLEEAIAEANRLPFGLAGYAFTRSFANVHLLTQRLEVGMLWINQPA 466 Query: 393 VHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVKSL 433 P +PFGGV +SG G+ G ++ E + +S V ++ Sbjct: 467 TPW--PEMPFGGVKDSGYGSEGGPEALEPYLVTKSVTVMAV 505 >6FK3-A nrPDB Length = 536 Score = 137 bits (346), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 118/430 (27%), Positives = 186/430 (43%), Gaps = 33/430 (7%) Query: 10 RAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLE 69 +AREAF R Q L L +++ +++ + ++GK E V E Sbjct: 64 KAREAFAEWSRTPAPIRGQVLFNLVKILEREKPTLTRLMVREVGKTP----KEAAGDVQE 119 Query: 70 ELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAV 129 +DT + + + + +L+ PLGVV +I A N+P + ++ AV Sbjct: 120 AIDTALFFASEGRRLYGQTVPSEMRDKELFTFRRPLGVVGIITAGNFPIAVPSWKLIPAV 179 Query: 130 AAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETT-----ELLKER-FD 182 GN V+ KPSE + ++ + A L + + + VV GG +T EL+ E F Sbjct: 180 LTGNTVVWKPSEDAPTLSFVFAKLFEEAGLPPGVLNVVFGGGKGSTGQWMVELMDEGLFQ 239 Query: 183 HIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQ 242 +TGST VG+ + A ++L TLELGGK+P V +D DLD+A W F GQ Sbjct: 240 KFAFTGSTQVGRWIGEVAGRNLIRPTLELGGKNPLVVMRDADLDLAVEGAWWSAFATGGQ 299 Query: 243 TCVAPDYILCDPSIQNQIVEK-LKKSLKDFYGEDAKQSR-DYGRIINDRHFQR------- 293 C + IL D I + + L++ G YG IN+R F R Sbjct: 300 RCTSAGNILVDAPIYEEFKRRFLERVEATLVGNPLLHPEVTYGPFINERFFARWQEHYRV 359 Query: 294 -----VKGLIDNQKVAHGGTW------DQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPI 342 + L ++ + ++ Y PT+ +V P + + EE+FGP + + Sbjct: 360 GEAEGARLLFGRGRITRENPYPRFLGDPEAGLYGWPTVW-EVRPGTRLFTEEVFGPTINL 418 Query: 343 VCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPF 402 V V +EEAI N L+ +++N+ +G + N+ V LPF Sbjct: 419 VKVDGIEEAIAVANSTPYGLSSAIYTNHRHWAYLFKVGIRAGMTSINNATVGAEA-HLPF 477 Query: 403 GGVGNSGMGA 412 GGV SG G Sbjct: 478 GGVKASGNGG 487 >3I44-A nrPDB Length = 497 Score = 137 bits (345), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 111/428 (25%), Positives = 198/428 (46%), Gaps = 24/428 (5%) Query: 8 VKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHV 67 + A++AF + KT S R+ +E + + + ++ ++ ++G + + A Sbjct: 69 INAAKKAFQTWKTTSPHERLGFVEKILEIYEKRSSDMAKTISMEMGAPIDMALNAQTATG 128 Query: 68 LEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVG 127 + IK +++ E + + + +H + +GVV +I WN+P N ++ Sbjct: 129 SSHIRNFIKAYKEFSFQEALIEGNE----QAILHYDAIGVVGLITPWNWPMNQVTLKVIP 184 Query: 128 AVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKER--FDHI 184 A+ AG ++LKPSE++ A L A ++ + + ++ ++ G L + I Sbjct: 185 ALLAGCTMVLKPSEIAPLSAMLFAEILDEAALPSGVFNLINGDGANVGSYLSAHPDLEMI 244 Query: 185 MYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTC 244 +TGST GK + A+ L V LELGGK + D D+D A +R F NSGQ+C Sbjct: 245 SFTGSTRAGKDISKNASNTLKRVCLELGGKGANIIFADADID-ALQRGVRHCFYNSGQSC 303 Query: 245 VAPDYILCDPSIQNQIVEKLKK-SLKDFYGEDAKQSRDYGRIINDRHFQRVKGLI----- 298 AP +L + +I ++ ++ K + K G + G +++ + +++ LI Sbjct: 304 NAPTRMLVEQAIYDKAIKTAKDIAEKTQVGPGHQTGNHIGPVVSKEQYDKIQDLIQSGID 363 Query: 299 DNQKVAHGGTW----DQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQF 354 + + GGT + Y+ PT+ DV P + +EEIFGPV+ ++ + +EA+ Sbjct: 364 EGATLVTGGTGLPMGMERGYYVRPTVFADVKPHMRIFREEIFGPVLSLLPFNTEDEAVTL 423 Query: 355 INQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGM---G 411 N E L Y+ S + +++ A+ SG V N H FGGV SG G Sbjct: 424 ANDTEYGLTNYIQSQDRSKCRRIAAQVRSGMVEVNG---HELPGGSYFGGVKFSGRAREG 480 Query: 412 AYHGKKSF 419 G K F Sbjct: 481 GLWGIKEF 488 >3R31-A nrPDB Length = 517 Score = 137 bits (344), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 105/350 (30%), Positives = 164/350 (46%), Gaps = 16/350 (4%) Query: 96 DDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLA-TLI 154 D Y PLGV + IGAWNYP + A+ AGNA++ KPSE + A +A LI Sbjct: 142 DFAYTKRVPLGVCVGIGAWNYPQQIACWKAAPALVAGNAMVFKPSENTPLGALKIAEILI 201 Query: 155 PQYMDQNLYLVVKGGVPETTELLKERFD--HIMYTGSTAVGKIVMAAAAKHLTPVTLELG 212 + + L+ V++G +T LL D + TGS G+ V AAAA HL VT+ELG Sbjct: 202 EAGLPKGLFNVIQGDR-DTGPLLVNHPDVAKVSLTGSVPTGRKVAAAAAGHLKHVTMELG 260 Query: 213 GKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF- 271 GKSP V D D++ A G F +SGQ C + + + +E LK+ + Sbjct: 261 GKSPMIVFDDADIESAVGGAMLGNFYSSGQVCSNGTRVFVQKKAKARFLENLKRRTEAMI 320 Query: 272 YGEDAKQSRDYGRIINDRHFQRVKGLIDNQK------VAHGGTWDQ---SSRYIAPTILV 322 G+ + G +++ ++V I+ K + GG + Y+ PT+ Sbjct: 321 LGDPLDYATHLGPLVSKAQQEKVLSYIEKGKAEGATLITGGGIPNNVAGEGAYVQPTVFA 380 Query: 323 DVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETS 382 DV + +EEIFGPVM ++ +E + N E LA VF+ + +++ Sbjct: 381 DVTDDMTIAREEIFGPVMCVLDFDDEDEVLARANATEFGLAGGVFTADLARAHRVVDGLE 440 Query: 383 SGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVKS 432 +G + N ++ +PFGG SG G + + E +S ++ V + Sbjct: 441 AGTLWIN--TYNLCPVEIPFGGSKQSGFGRENSAAALEHYSELKTVYVST 488 >4V6H-A nrPDB Length = 484 Score = 137 bits (344), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 97/325 (29%), Positives = 157/325 (48%), Gaps = 14/325 (4%) Query: 98 LYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY 157 + + EP+GV I WN+P + + + A+AAG +++KP+E + A +A L + Sbjct: 142 IVVVKEPIGVCAAITPWNFPAAMIARKVGPALAAGCPIVVKPAESTPFSALAMAFLAERA 201 Query: 158 MDQNLYLVVKGGVPET--TELLKERF-DHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGK 214 L V G P+ TE+ + +TGSTAVG+++MA +A + +TLELGG Sbjct: 202 GVPKGVLSVVIGDPKAIGTEITSNPIVRKLSFTGSTAVGRLLMAQSAPTVKKLTLELGGN 261 Query: 215 SPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YG 273 +P V D DLD A K+ N+GQTCV + + + +KL ++ G Sbjct: 262 APFIVFDDADLDAAVEGAIASKYRNNGQTCVCTNRFFVHERVYDAFADKLAAAVSKLKVG 321 Query: 274 EDAKQSRDYGRIINDRHFQRVKGLIDNQKVAHGGTWDQSSR-------YIAPTILVDVDP 326 + G +IN+ ++V+ I + +A G + + + PT+L V P Sbjct: 322 RGTESGATLGPLINEAAVKKVESHIADA-LAKGASLMTGGKRHALGHGFFEPTVLTGVKP 380 Query: 327 QSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGV 386 V +EE FGP+ P+ S EE ++ N E LA Y++S + + ++ G V Sbjct: 381 DMDVAKEETFGPLAPLFRFASEEELVRLANDTEFGLAAYLYSRDIGRVWRVAEALEYGMV 440 Query: 387 TANDVIVHITVPTLPFGGVGNSGMG 411 N ++ V PFGGV SG+G Sbjct: 441 GINTGLISNEVA--PFGGVKQSGLG 463 >6C43-A nrPDB Length = 477 Score = 137 bits (344), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 96/342 (28%), Positives = 154/342 (45%), Gaps = 12/342 (3%) Query: 100 IHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMD 159 I +P+GVV I WNYP + + A+AAGN V++KPSE++ A LA L Sbjct: 137 IRRDPIGVVASIAPWNYPLMMAAWKLAPALAAGNCVVIKPSEITPLTALKLAVLAKDIFP 196 Query: 160 QNLYLVVKGGVPETTELLK--ERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPC 217 + V+ G ++L E+ + TGS A G+ ++ A + +ELGGK+P Sbjct: 197 PGVLNVLFGRGQTVGDVLTGHEKVRMVSLTGSIATGEHILRHTAPAIKRTHMELGGKAPV 256 Query: 218 YVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDA 276 V D DLD + + F N+GQ C A I I + +VEKL ++ G Sbjct: 257 IVFDDADLDAVAQGVRTFGFYNAGQDCTAACRIYAQRGIYDALVEKLGNAVSSLKMGAPE 316 Query: 277 KQSRDYGRIINDRHFQRVKGLIDNQK-------VAHGGTWDQSSRYIAPTILVDVDPQSP 329 +S + G + + H +RV ++ K + G + Y APT+L D + Sbjct: 317 DESTELGPLSSLAHLKRVTAAVEEAKALSHIRVITGGSQTEGKGYYFAPTLLADAKQEDA 376 Query: 330 VMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTAN 389 ++Q E+FGPV+ I ++ +++ N LA V++ + ++ A G N Sbjct: 377 IVQREVFGPVVSITVFDDEDQVLRWANDSRYGLASSVWTQDVGRAHRLSARLQYGCTWIN 436 Query: 390 DVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVK 431 + V +P GG SG G E ++ R +VK Sbjct: 437 THF--MLVSEMPHGGQKQSGYGKDMSLYGLEDYTLVRHIMVK 476 >5UR2-A nrPDB Length = 984 Score = 137 bits (344), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 98/343 (28%), Positives = 163/343 (47%), Gaps = 14/343 (4%) Query: 106 GVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYL 164 GV VI WN+P + + A AGN V++KP+E S +A L +I + Q + Sbjct: 633 GVTAVIAPWNFPLAILAGMVTAAAVAGNTVVMKPAEQSTVVAWGLMKMIQEAGFPQGVIN 692 Query: 165 VVKGGVPETTE-LLKERFDH-IMYTGSTAVGKIVMAAAA------KHLTPVTLELGGKSP 216 + G E E ++ ++ I +TGS AVG +M AA +H+ +E+GGK+ Sbjct: 693 FLPGYGEEVGEYIVNHKYTTTIAFTGSKAVGLHIMNRAAVVQPGQQHVKRCIIEMGGKNA 752 Query: 217 CYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDA 276 +D D DLD A + + F SGQ C A ++ + ++ V++L ++ K A Sbjct: 753 VIIDNDADLDEAVDGVIYSAFGFSGQKCSAASRVIVLDEVYDRFVDRLVETAKSIEIHPA 812 Query: 277 KQSRDY-GRIINDRHFQRVKGLI----DNQKVAHGGTWDQSSRYIAPTILVDVDPQSPVM 331 + + Y G +++ + R+ G I N K+ G+ + PTI DV + + Sbjct: 813 ENPKAYMGPVVDKEAYDRILGTIAEAEKNHKLLFKGSVPGGGFFAPPTIFGDVPGDAKLA 872 Query: 332 QEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDV 391 Q EIFGPV+ ++ ++L++A+ N E L VFS + I ++ E G + N Sbjct: 873 QAEIFGPVVAVIRAKNLDQALDIANSTEYALTGGVFSRSPANINRVKEELEVGNLYVNRG 932 Query: 392 IVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVKSLL 434 I V PFGG SG+G+ G + +C+ ++ L Sbjct: 933 ITGAMVDRHPFGGFKMSGIGSKTGGPDYLKQYMEPACVTENTL 975 >4QYJ-A nrPDB Length = 516 Score = 137 bits (344), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 102/340 (30%), Positives = 165/340 (48%), Gaps = 16/340 (4%) Query: 104 PLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLY 163 P+GVV I WN+P + + + A+A GN V+LKP+E + A LA L + Sbjct: 178 PVGVVAAIIPWNFPLLMAVWKIAPALACGNTVVLKPAEETPLTALRLAELAMEAGLPAGA 237 Query: 164 LVVKGGVPETT--ELLKE-RFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVD 220 L V G ET L++ + + +TGST VG+I+ +A + L V+LELGGKSP V Sbjct: 238 LNVVTGRGETAGDALVRHPKVAKVAFTGSTEVGRIIGSACGRSLKAVSLELGGKSPVIVL 297 Query: 221 KDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQS 279 DCD A A F N GQ C A + SI ++++L + G +Q Sbjct: 298 ADCDPQEAAEGAAAAIFFNHGQVCTAGSRLYVHESIYEDVIQRLAVIGESIVVGSGLEQG 357 Query: 280 RDYGRIINDRHFQRV-----KGLIDNQKVAHGGTWDQSSR--YIAPTILVDVDPQS-PVM 331 G +++ +H + V G+ D + GGT ++ ++ PTI + + + ++ Sbjct: 358 VHMGPMVSKKHHENVLRHIRNGIEDGADLICGGTEAPCAQGFFVKPTIFANREKKDIRLL 417 Query: 332 QEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDV 391 +E+FGPV+ + E + N+ L +++N+ ++ E +G V N Sbjct: 418 SQEVFGPVLVATPFSDIAEVVNEANRSVYGLGASIWTNDLSAALRINDELEAGTVWVN-- 475 Query: 392 IVHITV-PTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLV 430 H V P LPFGG +SG+G HG + E ++ RS ++ Sbjct: 476 -THNMVDPNLPFGGFKDSGVGREHGAAAIEHYTTTRSLVI 514 >3RHD-A nrPDB Length = 486 Score = 136 bits (343), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 103/347 (29%), Positives = 168/347 (48%), Gaps = 22/347 (6%) Query: 98 LYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY 157 ++ EP+G+V I +N+P NL+ + A+A GN ++ PS + + LA +I Sbjct: 124 IFTRREPVGIVGAITPFNFPLNLSAHKIAPAIATGNVIVHHPSSKAPLVCIELAKIIENA 183 Query: 158 MDQ--------NLYLVVKGGVPETTELLKERFDHIMYTGSTAVGKIVMAAAAKHLTPVTL 209 + + NL L G V ++ E+ + I +TGS+ VG+++ A + L Sbjct: 184 LKKYNVPLGVYNL-LTGAGEVVGDEIVVNEKVNMISFTGSSKVGELITKKAG--FKKIAL 240 Query: 210 ELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLK 269 ELGG +P V KD DL+ A + G F+ +GQ C++ IL D SI ++ +E K Sbjct: 241 ELGGVNPNIVLKDADLNKAVNALIKGSFIYAGQVCISVGMILVDESIADKFIEMFVNKAK 300 Query: 270 DF-YGEDAKQSRDYGRIINDRHFQRVKGLIDNQ-----KVAHGGTWDQSSRYIAPTILVD 323 G + D G +I+ H + V+ +++ K+ GG D++ Y PTIL + Sbjct: 301 VLNVGNPLDEKTDVGPLISVEHAEWVEKVVEKAIDEGGKLLLGGKRDKALFY--PTIL-E 357 Query: 324 VDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSS 383 VD + + + E F PV+PI+ EE I N E L +F+N+ K Sbjct: 358 VDRDNILCKTETFAPVIPIIRTNE-EEMIDIANSTEYGLHSAIFTNDINKSLKFAENLEF 416 Query: 384 GGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLV 430 GGV ND + +PFGGV SG+G K + E S+ ++ ++ Sbjct: 417 GGVVINDSSL-FRQDNMPFGGVKKSGLGREGVKYAMEEMSNIKTIII 462 >3JZ4-A nrPDB Length = 481 Score = 136 bits (343), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 98/335 (29%), Positives = 158/335 (47%), Gaps = 12/335 (3%) Query: 98 LYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATL-IPQ 156 L + +P+GV I WN+P + + A+AAG ++LKP+ + A LA L I Sbjct: 139 LIVIKQPIGVTAAITPWNFPAAMITRKAGPALAAGCTMVLKPASQTPFSALALAELAIRA 198 Query: 157 YMDQNLYLVVKGGVPETTELLKER--FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGK 214 + ++ VV G L + +TGST +G+ +M AK + V+LELGG Sbjct: 199 GVPAGVFNVVTGSAGAVGNELTSNPLVRKLSFTGSTEIGRQLMEQCAKDIKKVSLELGGN 258 Query: 215 SPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFY-G 273 +P V D DLD A KF N+GQTCV + + + ++ EKL++++ + G Sbjct: 259 APFIVFDDADLDKAVEGALASKFRNAGQTCVCANRLYVQDGVYDRFAEKLQQAMSKLHIG 318 Query: 274 EDAKQSRDYGRIINDRHFQRVK-----GLIDNQKVAHGG-TWDQSSRYIAPTILVDVDPQ 327 + G +I+++ +V+ L +V GG ++ + PTILVDV Sbjct: 319 DGLDNGVTIGPLIDEKAVAKVEEHIADALEKGARVVCGGKAHERGGNFFQPTILVDVPAN 378 Query: 328 SPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVT 387 + V +EE FGP+ P+ + + I N E LA Y ++ + + ++ G V Sbjct: 379 AKVSKEETFGPLAPLFRFKDEADVIAQANDTEFGLAAYFYARDLSRVFRVGEALEYGIVG 438 Query: 388 ANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETF 422 N I+ V PFGG+ SG+G K E + Sbjct: 439 INTGIISNEVA--PFGGIKASGLGREGSKYGIEDY 471 >5J77-A nrPDB Length = 508 Score = 135 bits (339), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 89/331 (26%), Positives = 162/331 (48%), Gaps = 23/331 (6%) Query: 64 VAHVLEELDTTIKELPDWAE------DEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYP 117 V EE+D I ++ +AE E V T ++ ++ + P G+V+ + WN+P Sbjct: 94 VKEAKEEVDGVIDQIQYYAEWARKLNGEVVEGTSSHRK--IFQYKVPYGIVVALTPWNFP 151 Query: 118 FNLTIQPMVGAVAAGNAVILKPS-EVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTEL 176 + + + A+ GN V+LKPS + G ++ + + + + + G E + Sbjct: 152 AGMVARKLAPALLTGNTVVLKPSSDTPGSAEWIVRKFVEAGVPKGVLNFITGRGSEIGDY 211 Query: 177 LKE--RFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAW 234 + E + + I TGSTA G+ +M A+ ++ + LELGGK+P V KD D+D A + + W Sbjct: 212 IVEHKKVNLITMTGSTATGQRIMQKASANMAKLILELGGKAPFMVWKDADMDNALKTLLW 271 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRV 294 K+ N+GQ+C+A + + I + + + + + D K + D G +IN Q Sbjct: 272 AKYWNAGQSCIAAERLYVHEDIYDTFMSRFVELSRKLALGDPKNA-DMGPLINKGALQAT 330 Query: 295 KGLID-----NQKVAHGGTWD------QSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIV 343 +++ K+ GG+ ++ + PTI+ + D +S + QEEIF PV+ Sbjct: 331 SEIVEEAKESGAKILFGGSQPSLSGPYRNGYFFLPTIIGNADQKSKIFQEEIFAPVIGAR 390 Query: 344 CVRSLEEAIQFINQREKPLALYVFSNNEKVI 374 + S+EE N + LA Y+F+ + +I Sbjct: 391 KISSVEEMYDLANDNKYGLASYLFTKDPNII 421 >2D4E-A nrPDB Length = 515 Score = 134 bits (336), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 110/349 (31%), Positives = 166/349 (47%), Gaps = 22/349 (6%) Query: 80 DWAEDEPVAKTRQTQQDDLYIHSE-PLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILK 138 ++AE +T +D LY P G V +I WN P L+ + A+A GN V+LK Sbjct: 137 EYAEHAMEDRTFPVDRDWLYYTVRVPAGPVGIITPWNAPLMLSTWRIAPALAFGNTVVLK 196 Query: 139 PSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKER--FDHIMYTGSTAVGKI 195 P+E S A LA ++ + + ++ +V+G E L + TG T GKI Sbjct: 197 PAEWSPFTATKLAEILKEADLPPGVFNLVQGFGEEAGAALVAHPLVPLLTLTGETETGKI 256 Query: 196 VMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPS 255 VM AA HL ++ ELGGKSP V D DL+ A + + F +G+ C A +L + Sbjct: 257 VMRNAADHLKRLSPELGGKSPALVFADADLERALDAVVFQIFSFNGERCTASSRLLVEEK 316 Query: 256 IQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGLIDNQK-----VAHGGTW 309 I V K+ + + G + G +I+ H QRV G ++ K + GG Sbjct: 317 IFEDFVGKVVERARAIRVGHPLDPETEVGPLIHPEHLQRVLGYVEAGKREGARLLVGGER 376 Query: 310 DQSS---------RYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREK 360 ++S Y+ PT+ V + + QEEIFGPV+ + + EEA++ N + Sbjct: 377 AKTSFRGEDLSRGNYLLPTVFVG-ENHMKIAQEEIFGPVLVAIPFKDEEEALRKANDTKY 435 Query: 361 PLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSG 409 LA YVF+ + + ++ E +G V N V +PT PFGGV SG Sbjct: 436 GLAAYVFTRDLERAHRLALELEAGMVYLNSHNVR-HLPT-PFGGVKGSG 482 >6MVR-A nrPDB Length = 767 Score = 133 bits (334), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 95/324 (29%), Positives = 151/324 (46%), Gaps = 5/324 (1%) Query: 104 PLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNL 162 PLGV + WN+P + + A+A GN V+LKP+E + A L A + Q + + Sbjct: 155 PLGVCGQVIPWNFPLLMLAWKIAPALAMGNTVVLKPAEWTPLTALLFADICGQAGVPAGV 214 Query: 163 YLVVKGGVPETTELLKERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKD 222 +V G ++ + D + +TGSTAVG+ + A A ++LELGGK P V D Sbjct: 215 VNIVTGDGAVGEMIVTAQVDKVAFTGSTAVGRRIREATAGTGKALSLELGGKGPYVVCDD 274 Query: 223 CDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRD 281 D+D A + + N GQ C A +L I + KL+ + G+ + D Sbjct: 275 ADIDSAVEGLVDAIWFNQGQVCCAGSRLLVQEGIADVFHAKLRARMDSLRIGDPLDKCID 334 Query: 282 YGRIINDRHFQRVKGLI-DNQKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVM 340 G +++ RV+ ++ N T + Y PT++ + P SP+MQ+EIFGPV+ Sbjct: 335 IGAMVHPDQLARVRDMVAANTDGEVYQTAVPAGCYYPPTLISGLAPASPLMQQEIFGPVL 394 Query: 341 PIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTL 400 R+ EA++ N LA V+S N + + + +G V N ++ Sbjct: 395 VSTTFRTPAEAVEIANNTAYGLAASVWSENVNLALDLAPKLVAGIVWING--TNMMDAAA 452 Query: 401 PFGGVGNSGMGAYHGKKSFETFSH 424 PFGGV SG G G + ++ Sbjct: 453 PFGGVRESGFGREGGWEGLAGYTR 476 >3PRL-A nrPDB Length = 505 Score = 132 bits (332), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 118/449 (26%), Positives = 193/449 (42%), Gaps = 40/449 (8%) Query: 4 ISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEE 63 ++D ++ A++A K R + R+ L A ++ E + I + ++ K + S E Sbjct: 51 VNDAIQGAKDAQKIWKIRPIHERVDLLYAWADLLEERKEIIGELIMHEVAKPK-KSAIGE 109 Query: 64 VAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLY----------IHSEPLGVVLVIGA 113 V+ + + T DE + +T + D + + EPLGVVL I Sbjct: 110 VSRTADIIRHT--------ADEALRLNGETLKGDQFKGGSSKKIALVEREPLGVVLAISP 161 Query: 114 WNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMA--DLLATLIPQYMDQNLYLVVKGGVP 171 +NYP NL + A+ GN V+ KP+ G ++ ++ L + + VV G Sbjct: 162 FNYPVNLAAAKIAPALVTGNTVVFKPA-TQGSLSGIKMVEALADAGAPEGIIQVVTGRGS 220 Query: 172 ETTELLKERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRR 231 + L E M T + + + PV LELGGK P V D DL + + Sbjct: 221 VIGDHLVEHPGIDMITFTGGTTTGERISEKAKMIPVVLELGGKDPAIVLDDADLKLTASQ 280 Query: 232 IAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHF 291 I G F SGQ C A + S+ +Q+V +K+ ++ + D +I+++ Sbjct: 281 IVSGAFSYSGQRCTAIKRVFVQDSVADQLVANIKELVEQLTVGSPEDDADITPVIDEKSA 340 Query: 292 QRVKGLIDNQKVAHGGTW----DQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRS 347 ++GLID+ + +G T + ++PT+L DV P V EE FGPV+PI+ V+ Sbjct: 341 AFIQGLIDD-ALENGATLLSGNKRQGNLLSPTLLDDVTPAMRVAWEEPFGPVLPIIRVKD 399 Query: 348 LEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPT------LP 401 EAI NQ + L +F+ + + G VHI T P Sbjct: 400 ANEAISLSNQSDYGLQASIFTKDTDRAINIGKHLEVG-------TVHINAKTERGPDHFP 452 Query: 402 FGGVGNSGMGAYHGKKSFETFSHRRSCLV 430 F GV SG+G K S + + R ++ Sbjct: 453 FLGVKKSGLGVQGIKPSLLSMTRERVTVL 481 >3VZ0-A nrPDB Length = 459 Score = 132 bits (332), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 124/444 (27%), Positives = 196/444 (44%), Gaps = 35/444 (7%) Query: 2 SSISDTVKRAREAFNSG-KTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 + + D RA + + K RS+ R + + ++ + + + +A+++GK Sbjct: 27 AQMKDITDRAEHVWKTDWKLRSIAQRKEIVSRAADLLRRDRQHHASLIATEMGK------ 80 Query: 61 YEEVAHVLEELDTTIKELPDWAE--DEPVAKT-RQTQQDDLYIHSEPLGVVLVIGAWNYP 117 + LEE+D T L +A +E +A T + + I ++PLG++ I WN+P Sbjct: 81 --ALPDALEEIDVTADILSFYANGAEEFLAPTPLKVKTGQAKIINQPLGIIYCIEPWNFP 138 Query: 118 FNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLI-----PQYMDQNLYLVVKGGVPE 172 + + + AGN VI K + A L P N++L + Sbjct: 139 YYQLARVAGPNLMAGNVVIAKHAPNVPQCALAFEKLFHDAGAPVGAYANIFL----DNDQ 194 Query: 173 TTELLK-ERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRR 231 + EL+K ER + TGS G+ V A A L T+ELGG V D DLD+A + Sbjct: 195 SAELIKDERIRGVALTGSERAGQAVAAQAGAALKKDTMELGGSDAFIVLDDADLDLAVKW 254 Query: 232 IAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYG------- 283 WG+F N+GQ C A ++ + + ++ LK ++ F G + +G Sbjct: 255 AVWGRFANNGQVCTAAKRMIVHEKVYDAFLDGLKTAITRFRIGNPLDRDTTHGPMSSLRA 314 Query: 284 -RIINDRHFQRVKGLIDNQKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPI 342 + D+ + VKG VA G D+ ++ PTIL DV +PV +EIFGPV + Sbjct: 315 MELALDQTAEAVKG--GATLVAGGKRMDRKGFFMEPTILTDVSKDNPVFYQEIFGPVAVV 372 Query: 343 VCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPF 402 V S + AI N L VFS + +K+ + +G V N P LPF Sbjct: 373 HKVASEQAAIDLANDSPYGLGGAVFSRDIARAEKVAEQVETGMVFINTATA--AAPELPF 430 Query: 403 GGVGNSGMGAYHGKKSFETFSHRR 426 GG+ NSG G E F +R+ Sbjct: 431 GGIKNSGFGRELSFLGIEEFINRK 454 >4DNG-A nrPDB Length = 485 Score = 130 bits (327), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 96/338 (28%), Positives = 164/338 (48%), Gaps = 21/338 (6%) Query: 100 IHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKP---SEVSGHMADLLATLIPQ 156 I+ PLGV+ I +N+P NL+++ + A+A GN+V+ KP + +SG T+I + Sbjct: 139 IYRLPLGVISSISPFNFPMNLSMRSIAPAIALGNSVVHKPDIQTAISG------GTIIAK 192 Query: 157 YMDQ-----NLYLVVKGGVPETTE-LLKERFDHIM-YTGSTAVGKIVMAAAAKHLTPVTL 209 + + V+ V E + +L ++ +TGSTAVG+ + A + + L Sbjct: 193 AFEHAGLPAGVLNVMLTDVKEIGDGMLTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMAL 252 Query: 210 ELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLK 269 ELGG +P V D D+D A +GKF++ GQ C+ + I+ + ++ VEK +K Sbjct: 253 ELGGNNPFAVLSDADVDRAVDAAIFGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVK 312 Query: 270 DF-YGEDAKQSRDYGRIINDRHFQRVKGLIDNQK---VAHGGTWDQSSRYIAPTILVDVD 325 YG+ G +IN+R ++ +I+ K + + + P + V D Sbjct: 313 QLPYGDQTDPKTVVGPLINERQIEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGAD 372 Query: 326 PQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGG 385 S + Q E+F P+ I+ S +EAI N E L+ VF+++ + +K + SG Sbjct: 373 NNSKIAQTELFAPIATIIKAGSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGM 432 Query: 386 VTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFS 423 ND V+ + P + FGG SG+G + E F+ Sbjct: 433 THVNDQSVNDS-PNIAFGGNKASGVGRFGNPWVVEEFT 469 >2QE0-A nrPDB Length = 475 Score = 129 bits (323), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 99/336 (29%), Positives = 157/336 (46%), Gaps = 9/336 (2%) Query: 100 IHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-M 158 + EP+G+VL I +NYP NL + A+ AGN + KP LLA + + Sbjct: 139 VRREPVGLVLAISPFNYPVNLAGSKIAPALIAGNVIAFKPPTQGSISGLLLAEAFAEAGL 198 Query: 159 DQNLYLVVKGGVPETTELLKER--FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSP 216 ++ + G E + + E + I +TGST +G+ + A + P+ L LGGK Sbjct: 199 PAGVFNTITGRGSEIGDYIVEHQAVNFINFTGSTGIGERIGKMAG--MRPIMLALGGKDS 256 Query: 217 CYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDA 276 V +D DL++ + I G F SGQ C A +L S+ +++VEK+++ + + Sbjct: 257 AIVLEDADLELTAKNIIAGAFGYSGQRCTAVKRVLVMESVADELVEKIREKVLALTIGNP 316 Query: 277 KQSRDYGRIINDRHFQRVKGLID--NQKVAHGGT-WDQSSRYIAPTILVDVDPQSPVMQE 333 + D +I+ + V+GLI+ N K A T + I P + V + E Sbjct: 317 EDDADITPLIDTKSADYVEGLINDANDKGATALTEIKREGNLICPILFDKVTTDMRLAWE 376 Query: 334 EIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIV 393 E FGPV+PI+ V S+EEAI+ N+ E L +F+N+ + + G V N+ Sbjct: 377 EPFGPVLPIIRVTSVEEAIEISNKSEYGLQASIFTNDFPRAFGIAEQLEVGTVHINNKTQ 436 Query: 394 HITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCL 429 T PF G SG G K S E + +S + Sbjct: 437 RGT-DNFPFLGAKKSGAGIQGVKYSIEAMTTVKSVV 471 >4F3X-A nrPDB Length = 498 Score = 126 bits (317), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 95/343 (27%), Positives = 155/343 (45%), Gaps = 14/343 (4%) Query: 100 IHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMD 159 I +P+G+V I WNYP + + A+ GN V+ KPSE + A LA LI + Sbjct: 157 IRRDPIGIVGSIAPWNYPLMMMAWKLAPAIGGGNTVVFKPSEQTPLTALKLARLIADILP 216 Query: 160 QNLYLVVKG-GVPETTELLKE-RFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPC 217 + + V+ G G L+ + + TG A GK V+AAAAK + LELGGK+P Sbjct: 217 EGVVNVITGRGETVGNALINHPKVGMVSITGDIATGKKVLAAAAKTVKRTHLELGGKAPV 276 Query: 218 YVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDA 276 V D DL+ I + N+GQ C A I + I ++V L ++ Y D Sbjct: 277 IVYGDADLEAVVNGIRTFGYYNAGQDCTAACRIYAEAGIYEKLVADLTSAVSTIRYNLDD 336 Query: 277 KQSRDYGRIINDRHFQRVKGLID---NQK---VAHGG-TWDQSSRYIAPTILVDVDPQSP 329 + G +I+ R RV ++ +QK + GG T + PT++ + Sbjct: 337 DTENEIGPLISRRQRDRVASFVERAADQKHIEITTGGRTGSDEGFFFQPTVVAGATQEDE 396 Query: 330 VMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTAN 389 +++ E+FGPV+ + ++A+ + N + LA V++ K I K + S Sbjct: 397 IVRREVFGPVVSVTRFTGKDDAVAWANDSDYGLASSVWT---KDISKAMRAASRLQYGCT 453 Query: 390 DVIVHITVPT-LPFGGVGNSGMGAYHGKKSFETFSHRRSCLVK 431 + H + +P GG+ SG G + E ++ R ++ Sbjct: 454 WINTHFMLTNEMPHGGIKQSGYGKDMSVYALEDYTAVRHIMIN 496 >6B4R-B nrPDB Length = 497 Score = 125 bits (315), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 126/447 (28%), Positives = 205/447 (45%), Gaps = 22/447 (4%) Query: 1 MSSISDTVKRAREAFNSGKTRSLQ--FRIQQLEALQRMINENLKSISGALASDLGKNEWT 58 ++ VK AR AF+SG L R Q + ++ EN + ++ D+GK Sbjct: 56 LADAEQAVKVARNAFDSGAWSRLAPAKRKQTMIRFADLLLENAEELALLETLDMGKPISD 115 Query: 59 SYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPF 118 S + +VA L + + + D DE VA T + + EP+GVV I WN+P Sbjct: 116 SLHIDVASAANSLRWSAEAI-DKIYDE-VAATPHAELG--LVTREPVGVVAAIVPWNFPL 171 Query: 119 NLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATL-IPQYMDQNLYLVVKGGVPETTELL 177 ++ + A+A GN+VILKPSE S A +A L + + + ++ V+ G + L Sbjct: 172 LMSCWKLGPALATGNSVILKPSEKSPLTAIRIAQLAVEAGIPKGVFNVLPGYGHTVGKAL 231 Query: 178 KERF--DHIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDC-DLDVACRRIA 233 D +++TGST + K +M A + ++ V LE GGKSP V D DL A A Sbjct: 232 ALHMDVDTLVFTGSTKIAKQLMVYAGESNMKRVWLEAGGKSPNIVFADAPDLKAAAEAAA 291 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFY-GEDAKQSRDYGRIINDRHFQ 292 N G+ C A +L + SI+++ + + ++LK + G + G +++ + Sbjct: 292 GAIAFNQGEVCTAGSRLLVERSIKDKFLPLVIEALKGWKPGNPLDPETNVGALVDTQQMN 351 Query: 293 RVKGLI-----DNQKVAHGG--TWDQS-SRYIAPTILVDVDPQSPVMQEEIFGPVMPIVC 344 V I D K+ GG T +++ Y+ PTI V + +EEIFGPV+ ++ Sbjct: 352 TVLSYIEAGHNDGAKLVAGGKRTLEETGGTYVEPTIFDGVTNAMKIAREEIFGPVLSVIE 411 Query: 345 VRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGG 404 EEA++ N LA V+++N +G V N T PFGG Sbjct: 412 FEDAEEAVRIANDTPYGLAAAVWTSNLSKAHLTAKALRAGSVWVNQYDGGDM--TAPFGG 469 Query: 405 VGNSGMGAYHGKKSFETFSHRRSCLVK 431 SG G +F+ ++ ++ +K Sbjct: 470 FKQSGNGRDKSLHAFDKYTELKATWIK 496 >5VBF-A nrPDB Length = 478 Score = 123 bits (308), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 96/335 (28%), Positives = 161/335 (48%), Gaps = 22/335 (6%) Query: 103 EPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNL 162 EP+GV WN+PF+ + + A+A+G ++LK E S LA L + D L Sbjct: 141 EPIGVCAAFSPWNFPFSQAMHKIAAALASGCTLVLKGPEESPSAIVALAQL---FHDAGL 197 Query: 163 ---YLVVKGGVP-ETTELLKE--RFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSP 216 L + GVP + ++ L E + I +TGS VGK + A AA + +T+ELGG +P Sbjct: 198 PPGCLNIVWGVPGDVSKQLIEAPQVRKISFTGSVPVGKQLAALAASLMKRMTMELGGHAP 257 Query: 217 CYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF---YG 273 V D D++ A +A KF N+GQ CV+P + ++ V ++ YG Sbjct: 258 VLVCADADVERAAAMLAAYKFRNAGQVCVSPTRFFVQRAAFDRFVCAYLDAVGTIRVGYG 317 Query: 274 EDAKQSRDYGRIINDRHFQRVKGLIDN-----QKVAHGGT-WDQSSRYIAPTILVDVDPQ 327 DA + G + + R + + + ++A GG Y APT+++ Sbjct: 318 LDAGVT--MGPLAHARRVDEIDAFVADATAKGAQIATGGMRLPGPGHYFAPTVVLGPTRD 375 Query: 328 SPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVT 387 + +M +E FGP++ IV L++A+ N+ LA Y F+ + + ++ +G V Sbjct: 376 TRLMNDEPFGPIVGIVPFDDLDDALAEANRLPFGLASYAFTTSARNAHRISRALEAGMVN 435 Query: 388 ANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETF 422 N + +PFGGV +SG G+ G ++F+ + Sbjct: 436 INH--FGMGPAEIPFGGVKDSGFGSEGGMEAFDGY 468 >3RHO-A nrPDB Length = 517 Score = 122 bits (307), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 115/447 (25%), Positives = 203/447 (45%), Gaps = 37/447 (8%) Query: 1 MSSISDTVKRAREAFNSGKTRSLQFRIQQ--LEALQRMINENLKSISGALASDLGKNEWT 58 +S + V A+EAF +G + R + L L ++ ++ + ++ A D G Sbjct: 73 VSDVDKAVAAAKEAFENGLWGKINARDRGRLLYRLADVMEQHQEELATIEALDAGAVYTL 132 Query: 59 SYYEEVAHVLEELDTTIKELPDWAEDE-----PVAKTRQTQQDDLYIHSEPLGVVLVIGA 113 + V ++ T + W + P+ + R + L EP+GV ++ Sbjct: 133 ALKTHVGMSIQ----TFRYFAGWCDKIQGATIPINQARPNRNLTL-TKKEPVGVCGIVIP 187 Query: 114 WNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPET 173 WNYP + +AAGN V++KP++V+ A A L + + V +P + Sbjct: 188 WNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELT---LKAGIPKGVVNILPGS 244 Query: 174 TELLKERF-DH-----IMYTGSTAVGKIVMAAAA-KHLTPVTLELGGKSPCYVDKDCDLD 226 L+ +R DH I +TGST VGK +M + A ++ V+L+LGGKSP + DCDL+ Sbjct: 245 GSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCALSNVKKVSLQLGGKSPLIIFADCDLN 304 Query: 227 VACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRI 285 A + F N G+ C+A + + SI NQ V+K+ + ++ G ++ ++G Sbjct: 305 KAVQMGMSSVFFNKGENCIAAGRLFVEESIHNQFVQKVVEEVEKMKIGNPLERDTNHGPQ 364 Query: 286 INDRHFQRV-----KGLIDNQKVAHGGTWDQSSR---YIAPTILVDVDPQSPVMQEEIFG 337 ++ H +++ +G+ + + GG +Q R + PT+ DV+ + +EE FG Sbjct: 365 NHEAHLRKLVEYCQRGVKEGATLVCGG--NQVPRPGFFFQPTVFTDVEDHMYIAKEESFG 422 Query: 338 PVMPI--VCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHI 395 P+M I ++ + N E LA VF+ + + + +G V N + Sbjct: 423 PIMIISRFADGDVDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFIN--TYNK 480 Query: 396 TVPTLPFGGVGNSGMGAYHGKKSFETF 422 T PFGG SG G G+ + + Sbjct: 481 TDVAAPFGGFKQSGFGKDLGEAALNEY 507 >1WNB-A nrPDB Length = 495 Score = 122 bits (305), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 94/345 (27%), Positives = 153/345 (44%), Gaps = 18/345 (5%) Query: 100 IHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMD 159 I +PLGVV I WNYP + + A+AAGN V+LKPSE++ A LA L Sbjct: 155 IRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNCVVLKPSEITPLTALKLAELAKDIFP 214 Query: 160 QNLYLVVKG-----GVPETTELLKERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGK 214 + ++ G G P T + + TGS A G+ +++ A + +ELGGK Sbjct: 215 AGVVNILFGRGKTVGDPLTGH---PKVRMVSLTGSIATGEHIISHTASSIKRTHMELGGK 271 Query: 215 SPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YG 273 +P V D D++ + + N+GQ C A I I + +VEKL ++ G Sbjct: 272 APVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIYAQKGIYDTLVEKLGAAVATLKSG 331 Query: 274 EDAKQSRDYGRIINDRHFQRVKGLIDNQK-------VAHGGTWDQSSRYIAPTILVDVDP 326 +S + G + + H +RV ++ K + G + Y APT+L Sbjct: 332 APDDESTELGPLSSLAHLERVGKAVEEAKATGHIKVITGGEKRKGNGYYYAPTLLAGALQ 391 Query: 327 QSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGV 386 ++Q+E+FGPV+ + + E+ + + N + LA V++ + ++ A G Sbjct: 392 DDAIVQKEVFGPVVSVTPFDNEEQVVNWANDSQYGLASSVWTKDVGRAHRVSARLQYGCT 451 Query: 387 TANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVK 431 N + V +P GG SG G E ++ R +VK Sbjct: 452 WVNTHF--MLVSEMPHGGQKLSGYGKDMSLYGLEDYTVVRHVMVK 494 >3R64-A nrPDB Length = 508 Score = 121 bits (304), Expect = 6e-28, Method: Compositional matrix adjust. Identities = 101/342 (29%), Positives = 168/342 (49%), Gaps = 23/342 (6%) Query: 106 GVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLV 165 GVV VI WN+P NL+I+ + A+A GNAV++KP+ + + +IP + + V Sbjct: 150 GVVGVISPWNFPLNLSIRSVAPALAVGNAVVIKPASDT----PVTGGVIPARIFEEAG-V 204 Query: 166 VKGGVPETTELLKERFDH---------IMYTGSTAVGKIV--MAAAAKHLTPVTLELGGK 214 G + E DH I +TGST VG+ V +A + V LELGG Sbjct: 205 PAGVISTVAGAGSEIGDHFVTHAVPKLISFTGSTPVGRRVGELAINGGPMKTVALELGGN 264 Query: 215 SPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YG 273 +P V D D+D A + A G F++ GQ C++ + ++ D ++ ++ +EK +++K+ G Sbjct: 265 APFVVLADADIDAAAQAAAVGAFLHQGQICMSINRVIVDAAVHDEFLEKFVEAVKNIPTG 324 Query: 274 EDAKQSRDYGRIINDRHFQRVKGLIDNQKVAHGGTWDQ----SSRYIAPTILVDVDPQSP 329 + + + G +IND +K I+ K G T R + P + DV Sbjct: 325 DPSAEGTLVGPVINDSQLSGLKEKIELAK-KEGATVQVEGPIEGRLVHPHVFSDVTSDME 383 Query: 330 VMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTAN 389 + +EEIFGP++ ++ A + N + L+ V+S + + + SG V N Sbjct: 384 IAREEIFGPLISVLKADDEAHAAELANASDFGLSAAVWSKDIDRAAQFALQIDSGMVHIN 443 Query: 390 DVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVK 431 D+ V+ P + FGG NSG+G ++G + E F+ R +K Sbjct: 444 DLTVN-DEPHVMFGGSKNSGLGRFNGDWAIEEFTTDRWIGIK 484 >5KLK-A nrPDB Length = 520 Score = 119 bits (299), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 100/350 (28%), Positives = 159/350 (45%), Gaps = 20/350 (5%) Query: 99 YIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY- 157 Y +PLGV+ VI W+ P L + A+A GN V+ KPSE S A LLA ++ Sbjct: 173 YTVRKPLGVIGVISPWDLPLLLFTWKVAPALACGNTVVAKPSEESPSSATLLAEVMHDAG 232 Query: 158 MDQNLYLVVKG-GVPETTELLKER--FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGK 214 + ++ ++ G G E L + + +TG + G +M A A + V+ ELGGK Sbjct: 233 VPPGVFNLIHGFGKDSAGEFLTQHPGISALTFTGESKTGSTIMKAVADGVKEVSFELGGK 292 Query: 215 SPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLK-KSLKDFYG 273 + V D DLD A + F NSGQ C+ + + SI ++ V LK ++ + G Sbjct: 293 NAAVVFADADLDAAIEGVLRSSFTNSGQVCLCSERVYVHRSIFDEFVSGLKVEAERLVVG 352 Query: 274 EDAKQSRDYGRIINDRHFQRV-----KGLIDNQKVAHGG-------TWDQSSRYIAPTIL 321 + + G +I+ H +V + + V GG DQ + Y+ PTI Sbjct: 353 YPDQDGVNMGPLISHGHRDKVLSYYRLAVDEGATVVTGGGVPKFNDERDQGA-YVQPTIW 411 Query: 322 VDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAET 381 + ++ + EEIFGPV I +E I +N LA +++ N ++ + Sbjct: 412 TGLSDKARCVTEEIFGPVCHISPFDDEDEVINRVNDSNYGLACAIWTTNLSRAHRVSRQI 471 Query: 382 SSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVK 431 G V N ++ PFGGV SG+G G+ S + +S + +K Sbjct: 472 HVGLVWVN--TWYLRDLRTPFGGVKLSGLGREGGRFSMDFYSDIANICIK 519 >5KF0-A nrPDB Length = 485 Score = 119 bits (299), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 98/346 (28%), Positives = 164/346 (47%), Gaps = 21/346 (6%) Query: 99 YIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY- 157 Y P+G I +N+P NL + A+AAG +LKP+ + A ++A ++ + Sbjct: 146 YTRRVPIGPCSFISPFNFPLNLAAHKVAPALAAGCPFVLKPASRTPVGALIIAEVLAETN 205 Query: 158 MDQNLYLVV----KGGVPETTELLKERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGG 213 + + + V+ G TT+ ERF + +TGS AVG + A K V LELGG Sbjct: 206 LPKGAFSVLPAHRDGADLFTTD---ERFRLLSFTGSPAVGWALKEKAGKK--KVVLELGG 260 Query: 214 KSPCYVDKDC--DLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF 271 + VD D LD R+A+G + SGQ+C+ IL S+ + + +KL + Sbjct: 261 NAAAIVDADQFEQLDYVVDRLAFGAYYQSGQSCIGVQRILVHASLYDTLRDKLVAKTRSL 320 Query: 272 YGEDAKQSRDY-GRIINDRHFQRVKGLID-----NQKVAHGGTWDQSSRYIAPTILVDVD 325 D K + G +I++ +R+ G +D K+ GG D + T+L DV Sbjct: 321 KMGDPKDPSTFVGPMISESESRRLSGWMDAAVAAGAKIIAGGKVDGA--MFEATLLEDVG 378 Query: 326 PQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGG 385 + + ++E FGPV + ++A+ +N + L VF+++ ++ E GG Sbjct: 379 REQDLYRKEAFGPVAILEKFDRFDDALARVNDSDFGLQAGVFTDSLTHAQRAWDELEVGG 438 Query: 386 VTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVK 431 V NDV V +P+GGV +SG+G + + E + R +V+ Sbjct: 439 VVINDV-PSFRVDNMPYGGVKDSGLGREGIRYAIEDMTEPRLMVVR 483 >2W8P-A nrPDB Length = 487 Score = 119 bits (299), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 99/328 (30%), Positives = 160/328 (48%), Gaps = 20/328 (6%) Query: 100 IHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-M 158 + +P+GV VI WN+P + + + A+AAG V++KP+E + A LA L Q + Sbjct: 142 VLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGI 201 Query: 159 DQNLYLVV---KGGVPETTELL--KERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGG 213 +Y V+ + E E + I +TGST GKI++ AA + V++ELGG Sbjct: 202 PSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGG 261 Query: 214 KSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIV----EKLKKSLK 269 +P V ++D A KF N+GQT V + L I + V E +KK+L+ Sbjct: 262 LAPFIVFDSANVDQAVAGAMASKFRNTGQTAVCSNQFLVQRGIHDAFVKAFAEAMKKNLR 321 Query: 270 DFYGEDAKQSRDYGRIINDRHFQRVKGLIDN-----QKVAHGGTWDQSSR-YIAPTILVD 323 G ++ G +IN++ ++V+ +++ V GG Q + + PT+L + Sbjct: 322 --VGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCN 379 Query: 324 VDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSS 383 V EE FGP+ P++ + EEAI N + LA Y +S + I ++ + Sbjct: 380 VTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEV 439 Query: 384 GGVTANDVIVHITVPTLPFGGVGNSGMG 411 G V N+ + I+ PFGGV SG+G Sbjct: 440 GMVGVNEGL--ISSVECPFGGVKQSGLG 465 >5IUV-A nrPDB Length = 497 Score = 119 bits (298), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 123/444 (27%), Positives = 192/444 (43%), Gaps = 30/444 (6%) Query: 8 VKRAREAFNSGKTRSLQ--FRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEV- 64 V+ AR AF+SG L R + ++ +N + ++ D+GK S ++ Sbjct: 63 VESARSAFDSGAWSRLAPAKRKATMIRFAGLLEQNAEELALLETLDMGKPISDSLGVDIP 122 Query: 65 --AHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGAWNYPFNLT 121 A L I +L D + T D L + EP+GVV I WN+P + Sbjct: 123 GGARALSWSGEAIDKLYD--------EVAATPHDQLGLVTREPVGVVAAIVPWNFPLMMA 174 Query: 122 IQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTE---LLK 178 + A++ GN+V+LKPSE S A +A L + L V G T L Sbjct: 175 CWKLGPALSTGNSVVLKPSEKSPLTAIRIAQLAIEAGIPAGVLNVLPGYGHTVGKALALH 234 Query: 179 ERFDHIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDC-DLDVACRRIAWGK 236 D +++TGST + K +M A + ++ V LE GGKSP V D DL A A Sbjct: 235 MDVDTVVFTGSTKIAKQLMIYAGESNMKRVWLEAGGKSPNIVFADAPDLQAAADSAASAI 294 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFY-GEDAKQSRDYGRIINDRHFQRV- 294 N G+ C A +L + SI+++ + + ++L + G + + G +++ + V Sbjct: 295 AFNQGEVCTAGSRLLVERSIKDRFLPMVIEALGTWKPGNPLDPATNVGALVDTQQMNTVL 354 Query: 295 ----KGLIDNQKVAHGGTW---DQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRS 347 G D ++ GG + Y+ PTI V+ + QEEIFGPV+ ++ + Sbjct: 355 SYIAAGHTDGARLVAGGKQILQETGGTYVEPTIFDGVNNAMRIAQEEIFGPVLSVLTFDT 414 Query: 348 LEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGN 407 EEAIQ N LA V++ N +G V N T PFGG Sbjct: 415 AEEAIQIANDTPYGLAAAVWTANLSKAHLTARALRAGSVWVNQYDGGDM--TAPFGGFKQ 472 Query: 408 SGMGAYHGKKSFETFSHRRSCLVK 431 SG G +F+ ++ +S +K Sbjct: 473 SGNGRDKSLHAFDKYTELKSTWIK 496 >2J5N-A nrPDB Length = 516 Score = 119 bits (297), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 103/400 (25%), Positives = 171/400 (42%), Gaps = 29/400 (7%) Query: 36 MINENLKSISGALASDLGKNEWTSYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQ 95 ++ + + L ++GKN W +VA ++ ++ + + P + Sbjct: 108 LMRRRKRELEATLVYEVGKN-WVEASADVAEAIDFIEYYARAALRY--RYPAVEVVPYPG 164 Query: 96 DDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSE----VSGHMADLL- 150 +D PLG +VI WN+P + +VG VA GN VI KP+E V + ++ Sbjct: 165 EDNESFYVPLGAGVVIAPWNFPVAIFTGMIVGPVAVGNTVIAKPAEDAVVVGAKVFEIFH 224 Query: 151 -ATLIPQYMDQNLYLVVKGGVPETTELLKE--RFDHIMYTGSTAVGKIVMAAAAKHLTP- 206 A P ++ + G E L E R I +TGS VG + AA + L P Sbjct: 225 EAGFPPGVVN-----FLPGVGEEVGAYLVEHPRIRFINFTGSLEVGLKIYEAAGR-LAPG 278 Query: 207 ------VTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQI 260 +E GGK VD+ D D+A + + GQ C A ++ + Sbjct: 279 QTWFKRAYVETGGKDAIIVDETADFDLAAEGVVVSAYGFQGQKCSAASRLILTQGAYEPV 338 Query: 261 VEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLID-----NQKVAHGGTWDQSSRY 315 +E++ K + A+++ D G +++ ++V I+ Q V G + + Sbjct: 339 LERVLKRAERLSVGPAEENPDLGPVVSAEQERKVLSYIEIGKNEGQLVLGGKRLEGEGYF 398 Query: 316 IAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIK 375 IAPT+ +V P++ + QEEIFGPV+ ++ V+ EA++ N L V+S + ++ Sbjct: 399 IAPTVFTEVPPKARIAQEEIFGPVLSVIRVKDFAEALEVANDTPYGLTGGVYSRKREHLE 458 Query: 376 KMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHG 415 E G + N I V PFGG SG A G Sbjct: 459 WARREFHVGNLYFNRKITGALVGVQPFGGFKLSGTNAKTG 498 >3EFV-A nrPDB Length = 462 Score = 116 bits (290), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 108/449 (24%), Positives = 184/449 (40%), Gaps = 41/449 (9%) Query: 4 ISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEE 63 I + A F K S+ R Q L + + + + + ++ + ++GK Sbjct: 31 IEHALSLAASGFKKWKMTSVAQRAQTLRDIGQALRAHAEEMAQCITREMGK--------P 82 Query: 64 VAHVLEELDTTIKELPDW-AEDEPVAKTRQ---TQQDDLYIHSEPLGVVLVIGAWNYPFN 119 + E+ T L DW AE P + + I PLGV+L I WN+P Sbjct: 83 IKQARAEV-TKSAALCDWYAEHGPAMLNPEPTLVENQQAVIEYRPLGVILAIMPWNFPLW 141 Query: 120 LTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLK 178 ++ V + AGN+ +LK + A ++A ++ + +Y V ++++ Sbjct: 142 QVLRGAVPILLAGNSYLLKHAPNVTGCAQMIARILAEAGTPAGVYGWVNANNEGVSQMIN 201 Query: 179 E-RFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKF 237 + R + TGS G + A A L LELGG P V D DL++A + G++ Sbjct: 202 DPRIAAVTVTGSVRAGAAIGAQAGAALKKCVLELGGSDPFIVLNDADLELAVKAAVAGRY 261 Query: 238 MNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRI----INDRHFQ 292 N+GQ C A + + I ++ + G+ + D G + + D Q Sbjct: 262 QNTGQVCAAAKRFIVEEGIAQAFTDRFVAAAAALKMGDPLVEENDLGPMARFDLRDELHQ 321 Query: 293 RVKG--------LIDNQKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVC 344 +V+ L+ +K+A G Y A T+L DV P ++E+FGPV I Sbjct: 322 QVQASVAEGARLLLGGEKIAGEGN------YYAATVLADVTPDMTAFRQELFGPVAAITV 375 Query: 345 VRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGG 404 + A+ N E L+ +F+ ++ + +M A GGV N + + FGG Sbjct: 376 AKDAAHALALANDSEFGLSATIFTADDTLAAEMAARLECGGVFING--YSASDARVAFGG 433 Query: 405 VGNSGMGAYHGKKSFETFSHRRSCLVKSL 433 V SG G + F C V+++ Sbjct: 434 VKKSGFG-----RELSHFGLHEFCNVQTV 457 >3RH9-A nrPDB Length = 506 Score = 115 bits (289), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 114/415 (27%), Positives = 182/415 (43%), Gaps = 25/415 (6%) Query: 23 LQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEELDTTIKELPDWA 82 ++ R + LE ++ + EN + I L + GK W EV + D K + Sbjct: 70 IETRRKWLEDIRDGLKENREEIGRILCMEHGK-PWKEAQGEVDYAAGFFDYCAKHISALD 128 Query: 83 EDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKP-SE 141 K + +H P+GV +I WN+P + + + A+AAG ++KP SE Sbjct: 129 SHTIPEKPKDCT---WTVHYRPVGVTGLIVPWNFPIGMIAKKLSAALAAGCPSVIKPASE 185 Query: 142 VSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLKERFDHIM--YTGSTAVGKIVMAA 199 M + + + + +V G ++L E D M +TGST VG+ ++ Sbjct: 186 TPLTMIAFFSVMDKLDLPDGMVNLVMGKASVIGKVLCEHKDVPMLSFTGSTEVGRKLIVD 245 Query: 200 AAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQ 259 A+ + + LELGG +P V D DL+ A + KF GQTCV + I + + Sbjct: 246 TAEQVKKLALELGGNAPFIVFDDADLEAAADNLIANKFRGGGQTCVCANRIFVHEKVADA 305 Query: 260 IVEKLKKSL-KDFYGEDAKQSRDYGRIINDRHFQRVK-----------GLIDNQKVAHGG 307 +KL + + K G+ D G +IN + F +VK L+ ++ A G Sbjct: 306 FGQKLAERVNKMTVGDGMNDGIDIGPLINKQGFDKVKRHLQDALDKGASLVAGKQPAELG 365 Query: 308 TWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVF 367 + PT++ VD + QEE FGP++P+ R+ EE I N E LA YVF Sbjct: 366 ----DGLFFPPTVVQGVDREMCCYQEETFGPLVPMALFRTEEEVIDAGNDTEFGLASYVF 421 Query: 368 SNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETF 422 + + + +++ A G V N P PFGG+ SG+G G + F Sbjct: 422 TADAERAQRVAAGLRFGHVGWNTGTG--PTPEAPFGGMKASGIGREGGLEGLFEF 474 >1UXV-A nrPDB Length = 501 Score = 115 bits (288), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 112/408 (27%), Positives = 180/408 (44%), Gaps = 39/408 (9%) Query: 26 RIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHV----LEELDTTIKELP-- 79 R+ L +I NL + L + GK + + E A V L ELD +K++ Sbjct: 79 RLAVLRKAADIIERNLDVFAEVLVMNAGKPKSAAVGEVKAAVDRLRLAELD--LKKIGGD 136 Query: 80 ----DWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAV 135 DW D T + + + EPLGVV I +NYP + + + GNAV Sbjct: 137 YIPGDWTYD--------TLETEGLVRREPLGVVAAITPFNYPLFDAVNKITYSFIYGNAV 188 Query: 136 ILKPS---EVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLKERFDHIMYTGSTAV 192 ++KPS + MA + A L + + L+ G + +R + +TGST V Sbjct: 189 VVKPSISDPLPAAMA-VKALLDAGFPPDAIALLNLPGKEAEKIVADDRVAAVSFTGSTEV 247 Query: 193 G-KIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYIL 251 G ++V K +ELGG P V +D DLD+A +IA G + +GQ C A +L Sbjct: 248 GERVVKVGGVKQYV---MELGGGDPAIVLEDADLDLAADKIARGIYSYAGQRCDAIKLVL 304 Query: 252 CDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGLIDNQKVAHGGTWD 310 + + ++VE++ K L G+ + D G +I+ + I++ V GG Sbjct: 305 AERPVYGKLVEEVAKRLSSLRVGDPRDPTVDVGPLISPSAVDEMMAAIEDA-VEKGGRVL 363 Query: 311 QSSRYIAPTILVDVDPQSP--------VMQEEIFGPVMPIVCVRSLEEAIQFINQREKPL 362 R + PT + ++P + + E+F PV V V+ L++AI+ N R L Sbjct: 364 AGGRRLGPTYVQPTLVEAPADRVKDMVLYKREVFAPVALAVEVKDLDQAIELANGRPYGL 423 Query: 363 ALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGM 410 VF + I++ + G + ND+ H + PFGG SG+ Sbjct: 424 DAAVFGRDVVKIRRAVRLLEVGAIYINDMPRH-GIGYYPFGGRKKSGV 470 >3EK1-A nrPDB Length = 504 Score = 115 bits (288), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 96/334 (28%), Positives = 154/334 (46%), Gaps = 12/334 (3%) Query: 98 LYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY 157 L + +P+GV I WN+P + + A+AAG +I++P++++ A L L + Sbjct: 162 LTVIRQPVGVTAAITPWNFPAAMITRKAAPALAAGCTMIVRPADLTPLTALALGVLAEKA 221 Query: 158 -MDQNLYLVVKGGVPETTELL--KERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGK 214 + + +V G E L + + +TGST VG+++MA A + ++LELGG Sbjct: 222 GIPAGVLQIVTGKAREIGAELTSNDTVRKLSFTGSTEVGRLLMAQCAPTIKRISLELGGN 281 Query: 215 SPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YG 273 +P V D DLD A K+ N+GQTCV + I + ++ EKL +K+ G Sbjct: 282 APFIVFDDADLDAAVDGAMVSKYRNAGQTCVCANRIYVQRGVYDKFAEKLAAKVKELKVG 341 Query: 274 EDAKQSRDYGRIINDRHFQRVKGLIDN-----QKVAHGGTWDQSSRYIAPTILVDVDPQS 328 + G +I ++ +VK I++ K+ GG + + P IL V Sbjct: 342 NGTEPGVVIGPMIEEKAITKVKAHIEDAVSKGAKLITGGK-ELGGLFFEPGILTGVTSDM 400 Query: 329 PVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTA 388 V +EE FGP+ P+ + EE I N LA Y ++ N ++ G V Sbjct: 401 LVAKEETFGPLAPLFAFDTEEEVIAQANDTIFGLAAYFYTENFSRAIRVSEALEYGMVGH 460 Query: 389 NDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETF 422 N ++ V PFGGV SG+G K E + Sbjct: 461 NTGLISNEVA--PFGGVKQSGLGREGSKYGIEEY 492 >4I3V-A nrPDB Length = 488 Score = 114 bits (286), Expect = 7e-26, Method: Compositional matrix adjust. Identities = 107/348 (30%), Positives = 166/348 (47%), Gaps = 29/348 (8%) Query: 98 LYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY 157 ++ EPL + I +N+P N+ + A+A N V++KP+E++ A LLA ++ + Sbjct: 144 IFTMREPLTAISAITPFNHPLNMVAHKVAPAIATNNCVVVKPTELTPMTALLLADILYEA 203 Query: 158 MDQNLYLVVKGGVPETTEL---LKERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGK 214 L V G P + D + +TGS VGK++ AA H LELGG Sbjct: 204 GLPPEMLSVVTGWPADIGMEMITNPHVDLVTFTGSVPVGKLI--AANAHYKRQVLELGGN 261 Query: 215 SPCYVDKDC---DLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVE-KLKKSLKD 270 P + D DL A G NSGQ C A ILC S+ ++ V L+++ + Sbjct: 262 DPLIILNDLSDDDLARAADLAVAGATKNSGQRCTAVKRILCQESVADRFVPLVLERAKRL 321 Query: 271 FYGEDAKQSRDYGRIINDRHF----QRVKGLIDNQK--VAHGGTWDQSSRYIAPTILVDV 324 +G+ +S D G +I+++ +RV + + H G S + P I+VD Sbjct: 322 RFGDPMDRSTDLGTVIHEKAAALFEERVMRAAEEGADILYHPG----RSGALLPPIVVDR 377 Query: 325 DP-QSPVMQEEIFGPVMPIVCVRSLEEA-IQFINQREKPLALYVFSNNEKVIKKMIAETS 382 P QS ++ EE FGP++PIV V ++A I N L+ V +N+ + ++K IA Sbjct: 378 VPHQSDLVLEETFGPIIPIVRVPDDDDATITLSNSTAFGLSSGVCTNDYRRMQKYIAGLK 437 Query: 383 SGGVTANDVIVHITVPTLPFGGVGNSGMGAYHG----KKSF---ETFS 423 G V +V + + PFGG+ +SG G G KSF +TFS Sbjct: 438 VGTVNIWEVPGY-RIEMSPFGGIKDSGNGYKEGVIEAMKSFTNVKTFS 484 >5JRY-A nrPDB Length = 485 Score = 114 bits (285), Expect = 9e-26, Method: Compositional matrix adjust. Identities = 95/346 (27%), Positives = 161/346 (46%), Gaps = 21/346 (6%) Query: 99 YIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY- 157 Y P+G I +N+P NL + A+AAG +LKP+ + A ++ ++ + Sbjct: 146 YTRRVPIGPCSFISPFNFPLNLAAHKVAPALAAGCPFVLKPASRTPVGALIIGEVLAETD 205 Query: 158 MDQNLYLVV----KGGVPETTELLKERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGG 213 + + + V+ G TT+ +RF + +TGS AVG + A K V LELGG Sbjct: 206 LPKGAFSVLPAHRDGADLFTTD---DRFRLLSFTGSPAVGWALKEKAGKK--KVVLELGG 260 Query: 214 KSPCYVDKDC--DLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF 271 + VD D LD R+A+G F SGQ+C+ IL I + + +KL + Sbjct: 261 NAAAIVDADQLDRLDYVVDRLAFGAFYQSGQSCIGVQRILAHADIYDALRDKLIAKTRSL 320 Query: 272 YGEDAKQSRDY-GRIINDRHFQRVKGLID-----NQKVAHGGTWDQSSRYIAPTILVDVD 325 D K + G +I++ +R+ G +D K+ GG D + T+L +V Sbjct: 321 KMGDPKDPSTFVGPMISESESRRLSGWMDAAVAAGAKIVAGGKVDGA--MFEATLLENVG 378 Query: 326 PQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGG 385 + ++E FGP+ + ++A+ +N + L VF+++ ++ E GG Sbjct: 379 RDQDLYRKEAFGPIAILEKFDRFDDALARVNDSDFGLQAGVFTDSLAHTQQAWDELEVGG 438 Query: 386 VTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVK 431 V NDV V +P+GGV +SG+G + + E + R +V+ Sbjct: 439 VVINDV-PSFRVDNMPYGGVKDSGLGREGIRYAIEDMTEPRLLVVR 483 >5U0M-A nrPDB Length = 497 Score = 112 bits (281), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 109/429 (25%), Positives = 197/429 (45%), Gaps = 36/429 (8%) Query: 1 MSSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 + + V+ AR+AF + + +SL R +EA ++ N + ++ + + GK W S Sbjct: 47 LEDVDAAVREARKAFLAWRRKSLAERQAVIEAFGELLEANKEELAHQIGLETGKPLWESR 106 Query: 61 YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHS----EPLGVVLVIGAWNY 116 EVA ++ ++ ++K A +E +T T+ D H+ P GVV V G +N+ Sbjct: 107 -TEVAAMMGKIPISVK-----AYNE---RTGHTESDVAGGHAVLRHRPHGVVAVFGPYNF 157 Query: 117 PFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTE 175 P +L +V A+ AGN V+ KPSE++ +A+L L + + + +V+GG Sbjct: 158 PGHLPNGHIVPALLAGNTVVFKPSELTPGVAELTVRLWEKAGLPDGVINLVQGGSDTGKC 217 Query: 176 LLKERF-DHIMYTGSTAVGKIVMAAAAKHLTPV-TLELGGKSPCYVDKDCDLDVACRRIA 233 L + D + +TGS+ VG ++ + LE+GG +P V DLD A Sbjct: 218 LARHSLIDGLFFTGSSTVGHLLHEQFGGQPEKILALEMGGNNPLIVQNVSDLDGAVHHAL 277 Query: 234 WGKFMNSGQTCVAPDYILC------DPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIIN 287 F+++GQ C +L D + + + ++ +F DA G +I+ Sbjct: 278 QSAFLSAGQRCTCARRLLVPKGKKGDEFLARLVEVAARITVAEF---DADPQPFMGSVIS 334 Query: 288 DRHFQRVKGLIDNQK--VAHGGTWDQSSRYIAP-TILVD---VDPQSPVMQ-EEIFGPVM 340 + L+ Q + G T + + P T L+ VD ++ +E FGP++ Sbjct: 335 A---EAANQLLKAQAAMLEKGATSLLEMKQLKPDTGLLSPGIVDATGIELEDQEFFGPLL 391 Query: 341 PIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTL 400 + + +EA++ N L+ + S++ K+ +++ E +G V N + + Sbjct: 392 TVYRYKGFDEALELANNTRYGLSAGILSDDRKLYNRLVEEVRAGIVNWNRPLTGAS-SAA 450 Query: 401 PFGGVGNSG 409 PFGGVG SG Sbjct: 451 PFGGVGASG 459 >2JG7-A nrPDB Length = 510 Score = 112 bits (280), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 104/456 (22%), Positives = 203/456 (44%), Gaps = 42/456 (9%) Query: 1 MSSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 ++ +TV++ REA+ R + + + + + +K + ++ ++GK Y Sbjct: 56 LAEYEETVQKTREAWKMWADIPAPKRGEIVRQIGDALRKKIKVLGSLVSLEMGK----IY 111 Query: 61 YEEVAHVLEELDTTIKELPDWAED------EPVAKTRQTQQDDLYIHSEPLGVVLVIGAW 114 E V V E +D D+A PV + + L P+G+V +I A+ Sbjct: 112 VEGVGEVQEYVDVC-----DYAVGLSRMIGGPVLPSERPGHA-LIEQWNPVGLVGIITAF 165 Query: 115 NYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQN-----LYLVVKGG 169 N+P + A+ GN + K + + + + ++ + ++QN + + GG Sbjct: 166 NFPVAVYGWNNAIALTCGNVCLWKGAPTTPLTSVAVTKIVAEVLEQNNLPGAICSMTCGG 225 Query: 170 VPETTELLK-ERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVA 228 T + K ER D + +TGST VGK+V + LELGG + V +D DL++ Sbjct: 226 ADIGTAMAKDERVDLLSFTGSTHVGKMVAMMVQERFGRKLLELGGNNAIIVFEDADLNLV 285 Query: 229 CRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIIN 287 + +GQ C ++ S+ + +VE++ K+ K G+ S YG + Sbjct: 286 VPSAVFASVGTAGQRCTTTRRLMLHESVHDAVVERIAKAYKQVRIGDPWDPSTLYGPLHT 345 Query: 288 DRHFQRVKGLIDNQK------VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMP 341 + + I+ K V G D+ Y+ PTI+ + +P++ E F P++ Sbjct: 346 KQAVDQYLAAIEQAKQQGGTLVCGGKVMDRPGNYVEPTIITGLAHDAPIVHTETFVPILY 405 Query: 342 IVCVRSLEEAIQFINQREKPLALYVFSNN-EKVIKKMIAETSSGGVTANDVIVHITVPTL 400 ++ ++ EEA + N+ ++ L+ +F+ + +V + + + S G IV++ +PT Sbjct: 406 VLKFKTEEEAFAWNNEVQQGLSSSIFTKDLGRVFRWLGPKGSDCG------IVNVNIPTS 459 Query: 401 ------PFGGVGNSGMGAYHGKKSFETFSHRRSCLV 430 FGG ++G G G S++ + R +C + Sbjct: 460 GAEIGGAFGGEKHTGGGRESGSDSWKQYMRRSTCTI 495 >5N5S-A nrPDB Length = 515 Score = 110 bits (276), Expect = 9e-25, Method: Compositional matrix adjust. Identities = 88/320 (27%), Positives = 151/320 (47%), Gaps = 21/320 (6%) Query: 104 PLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLY 163 P+G V ++ WN+P NL + A+A G +LKP+ + A +L ++ + + L Sbjct: 178 PIGPVSMVSPWNFPLNLVAHKVAPAIAVGCPFVLKPASRTPLSALILGEILHKI--EELP 235 Query: 164 LVVKGGVPETTE-----LLKERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCY 218 L +P + E + ERF + +TGS +G + A A K V +ELGG +PC Sbjct: 236 LGAFSILPVSREDADMFTVDERFKLLTFTGSGPIGWDMKARAGKK--KVVMELGGNAPCI 293 Query: 219 VDKDC-DLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDA 276 VD DLD +R+ G F GQ+C+ + + +++ E ++K G Sbjct: 294 VDDYVPDLDYTIQRLINGGFYQGGQSCIHMQRLYVHERLYDEVKEGFVAAVKKLKMGNPF 353 Query: 277 KQSRDYGRIINDRHFQRVKGLID--NQKVAHGGTW----DQSSRYIAPTILVDVDPQSPV 330 ++ G +I++ KG+ D + VA GG ++ +I PT++ DV ++ Sbjct: 354 EEDTYLGPMISE---SAAKGIEDWVKEAVAKGGKLLTGGNRKGAFIEPTVIEDVPIEANA 410 Query: 331 MQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTAND 390 +EEIFGPV+ + +EA++ N L +F+ + GGV ND Sbjct: 411 RKEEIFGPVVLLYKYSDFKEAVKECNNTHYGLQSGIFTKDLNKAFYAFEHMEVGGVILND 470 Query: 391 VIVHITVPTLPFGGVGNSGM 410 + V + P+GG+ +SG+ Sbjct: 471 SPA-LRVDSQPYGGLKDSGI 489 >4JZ6-A nrPDB Length = 500 Score = 109 bits (273), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 95/366 (25%), Positives = 156/366 (42%), Gaps = 44/366 (12%) Query: 103 EPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQ------ 156 +P+G +L I WN L + + + GN V+ K SE S L+ + + Sbjct: 154 QPVGPILSIVPWNGTAVLAARAIAYPLVCGNTVVFKGSEFSPATHALITQCVQEAGLPAG 213 Query: 157 ---YMDQNLYLVVKGGVPETTELL--KERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLEL 211 Y++ + PE + L + I +TGST VG I+ AA+HL LEL Sbjct: 214 VLNYLNSS-----PDRSPEIADALISAKEIRRINFTGSTRVGSIIAQKAAQHLKRCLLEL 268 Query: 212 GGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF 271 GGKSP V D D++ A + +G F+ GQ C++ + ++ D I ++ V + + + Sbjct: 269 GGKSPLIVLDDADINAAVKAAVFGSFLFQGQICMSTERLVVDEKIADEFVARFVEKTERL 328 Query: 272 YGEDAKQSRD--YGRIINDRHFQRVKGLIDN-----QKVAHGGTWDQSSRYIAPTILVDV 324 D + D G +++ +R+ GL + KV GG + TIL V Sbjct: 329 SVGDPCLTGDCIIGPMVSPNSGERINGLFKDAIDKGAKVVCGGM--AQGAVMPATILDHV 386 Query: 325 DPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSG 384 + EE FGP+ ++ + EAI+ N L+ VF + I Sbjct: 387 KSDMRIYDEETFGPITVVIRCKGEAEAIRIANDSVYGLSSGVFGRD-------INRALRV 439 Query: 385 GVTANDVIVHITVPTL------PFGGVGNSGMGAYHGKKSFETFSHRRSCLVKSLLNEEA 438 G++ VHI T+ P+GG N+G G + G+ + F+ + L E Sbjct: 440 GMSIEYGCVHINGSTVQNEAQAPYGGTKNTGYGRFDGRAVIDEFTELK------WLTIEP 493 Query: 439 HKARYP 444 + +YP Sbjct: 494 FEQQYP 499 >3JU8-A nrPDB Length = 490 Score = 108 bits (270), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 102/423 (24%), Positives = 185/423 (43%), Gaps = 25/423 (5%) Query: 2 SSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 + + V AREAF + R L+ RI+ LE + ++ + + GK W S Sbjct: 42 TQVDAAVCAAREAFPAWARRPLEQRIELLERFAATLKSRADELARVIGEETGKPLWESA- 100 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLT 121 EV ++ ++ +++ + + K+ + +P GVV V G +N+P +L Sbjct: 101 TEVTSMVNKVAISVQAFRERTGE----KSGPLADATAVLRHKPHGVVAVFGPYNFPGHLP 156 Query: 122 IQPMVGAVAAGNAVILKPSEVSGHMADL-LATLIPQYMDQNLYLVVKGGVPETTELLKER 180 +V A+ AGN V+ KPSE++ +A+L L I + + +V+GG L R Sbjct: 157 NGHIVPALLAGNCVVFKPSELTPKVAELTLKAWIQAGLPAGVLNLVQGGRETGVALAAHR 216 Query: 181 -FDHIMYTGSTAVGKIVMAAAAKHLTPV-TLELGGKSPCYVDKDCDLDVACRRIAWGKFM 238 D + +TGS+ G ++ + + LE+GG +P V++ DLD A I F+ Sbjct: 217 GLDGLFFTGSSRTGNLLHSQFGGQPQKILALEMGGNNPLVVEEVADLDAAVYTIIQSAFI 276 Query: 239 NSGQTCVAPDYILC------DPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIIN---DR 289 ++GQ C +L D + + + F D + + G +I+ Sbjct: 277 SAGQRCTCARRLLVPQGAWGDALLARLVAVSATLRVGRF---DEQPAPFMGAVISLSAAE 333 Query: 290 HFQRVKGLIDNQKVAHGGTWDQ---SSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVR 346 H + + + + Q + + P IL DV + EE FGP++ ++ Sbjct: 334 HLLKAQEHLIGKGAQPLLAMTQPIDGAALLTPGIL-DVSAVAERPDEEFFGPLLQVIRYS 392 Query: 347 SLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVG 406 AI+ N + LA + S++ + ++ + E+ +G V N + + PFGG+G Sbjct: 393 DFAAAIREANATQYGLAAGLLSDSRERFEQFLVESRAGIVNWNKQLTG-AASSAPFGGIG 451 Query: 407 NSG 409 SG Sbjct: 452 ASG 454 >1T90-A nrPDB Length = 486 Score = 107 bits (267), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 106/453 (23%), Positives = 202/453 (44%), Gaps = 28/453 (6%) Query: 4 ISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEE 63 I + A EAF + ++ R + L Q++++++ + ++ + + GKN + E Sbjct: 45 IDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEAL-GE 103 Query: 64 VAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQ 123 V +E ++ P + +A + Y + P+GVV I +N+P + Sbjct: 104 VGRGIENVEFAAGA-PSLMMGDSLASIATDVEAANYRY--PIGVVGGIAPFNFPMMVPCW 160 Query: 124 PMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKE-RF 181 A+A GN ILKPSE + + + L L + + + ++ VV G +L+ Sbjct: 161 MFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEHPEI 220 Query: 182 DHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSG 241 I + GS VG+ V +++L V G K+ V D +L+ I F ++G Sbjct: 221 KAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAAFGSAG 280 Query: 242 QTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRV-----K 295 + C+A + + I ++ + KL++ + D G G +I + + +R K Sbjct: 281 ERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKRTLSYIEK 340 Query: 296 GLIDNQKVAHGGTWDQS--SRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQ 353 GL + ++ G + S ++ PTI +V + + ++EIF PV+ ++ V++L+EAI+ Sbjct: 341 GLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIRVKNLKEAIE 400 Query: 354 FINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAY 413 N+ E +F++N I + E G+ ++ V + PF G +S G Sbjct: 401 IANKSEFANGACLFTSNSNAI-RYFRENIDAGMLGINLGVPAPMAFFPFSGWKSSFFGTL 459 Query: 414 H--GKKSFETFSHRRSCLVKSLLNEEAHKARYP 444 H GK S + ++ ++ ARYP Sbjct: 460 HANGKDSVDFYTRKKVV-----------TARYP 481 >4OGD-A nrPDB Length = 465 Score = 107 bits (266), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 99/435 (22%), Positives = 192/435 (44%), Gaps = 29/435 (6%) Query: 4 ISDTVKRAREAFNSG-KTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE 62 ++D ++RA + K L+ R QL + ++ + + + D+GK + Sbjct: 25 LADVLERAHLLYKKWRKEDHLEERKAQLHQVANILRRDRDKYAEIMTKDMGK-----LFT 79 Query: 63 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTI 122 E ++ D A++ ++ +T Y + GV+L + WN+P+ + Sbjct: 80 EAQGEVDLCADIADYYADKADEFLMSTPLETDSGQAYYLKQSTGVILAVEPWNFPYYQIM 139 Query: 123 QPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQ-----NLYLVVKGGVPETTELL 177 + GN ++LK + + A L+ + + NL++ + ++++ Sbjct: 140 RVFAPNFIVGNPMVLKHASICPRSAQSFEELVLEAGAEAGSITNLFI----SYDQVSQVI 195 Query: 178 KE-RFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGK 236 + R + TGS G + A K+L TLELGG + D D D + + + + Sbjct: 196 ADKRVVGVCLTGSERGGASIAEEAGKNLKKTTLELGGDDAFIILDDADWDQLEKVLYFSR 255 Query: 237 FMNSGQTCVAPD-YILCDPSIQ--NQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRH--- 290 N+GQ C + +I+ D +++ K+ K+ K +G+ + + + Sbjct: 256 LYNAGQVCTSSKRFIVLDKDYDRFKELLTKVFKTAK--WGDPMDPETTLAPLSSAQAKAD 313 Query: 291 -FQRVKGLIDN-QKVAHGG-TWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRS 347 ++K +D+ ++ +GG D ++ PTI+ + +P+ +EIFGPV I V S Sbjct: 314 VLDQIKLALDHGAELVYGGEAIDHPGHFVMPTIIAGLTKDNPIYYQEIFGPVGEIYKVSS 373 Query: 348 LEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGN 407 EEAI+ N L +FS+N++ K + A+ +G N ++P LPFGG+ + Sbjct: 374 EEEAIEVANDSNYGLGGTIFSSNQEHAKAVAAKIETGMSFINSGWT--SLPELPFGGIKH 431 Query: 408 SGMGAYHGKKSFETF 422 SG G + F +F Sbjct: 432 SGYGRELSELGFTSF 446 >5J6B-A nrPDB Length = 485 Score = 105 bits (263), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 92/346 (26%), Positives = 159/346 (45%), Gaps = 21/346 (6%) Query: 99 YIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY- 157 Y P+G I +N+P NL + A+AAG +LKP+ + A ++ ++ + Sbjct: 146 YYKRVPIGPCSFISPFNFPLNLAAHKVAPALAAGCPFVLKPASRTPIGALIIGEVLAETD 205 Query: 158 MDQNLYLVV----KGGVPETTELLKERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGG 213 + + + ++ G TT+ ERF + +TGS VG + A K V LELGG Sbjct: 206 LPKGAFSILPAHRDGADLFTTD---ERFKLLSFTGSPTVGWELKKKAGKKK--VVLELGG 260 Query: 214 KSPCYVDKDCD--LDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF 271 + VD D LD R+A+G + SGQ+C+ I+ + + + EKL + Sbjct: 261 NAAAIVDADQREVLDYVVERLAFGAYYQSGQSCIGVQRIIAHADVYDALREKLIAKTRSL 320 Query: 272 YGEDAKQSRDY-GRIINDRHFQRVKGLID-----NQKVAHGGTWDQSSRYIAPTILVDVD 325 D K + G +I++ +R+ G ++ K+ GG D + T+L V Sbjct: 321 KMGDPKDPATFVGPMISESEARRLAGWMEAAVAAGAKIVAGGKVDGA--MFEATLLEGVG 378 Query: 326 PQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGG 385 + ++E FGPV + ++A+ +N + L VF+++ ++ E GG Sbjct: 379 RDQDLYRKEAFGPVALLERFSDFDDALARVNDSDFGLQAGVFTDSLSHAQRAWDELEVGG 438 Query: 386 VTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVK 431 V NDV V +P+GGV +SG+G + + E + R +V+ Sbjct: 439 VVINDV-PSFRVDNMPYGGVKDSGLGREGIRYAIEDMTELRLMVVR 483 >4PXN-A nrPDB Length = 525 Score = 102 bits (255), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 98/399 (24%), Positives = 181/399 (45%), Gaps = 39/399 (9%) Query: 63 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSE-----------PLGVVLVI 111 E+ +L E ++E+ D D V +RQ + I SE PLGVV VI Sbjct: 122 EMGKILPEGIGEVQEIIDMC-DYAVGLSRQL--NGSIIPSERPNHMMMEVWNPLGVVGVI 178 Query: 112 GAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQN-----LYLVV 166 A+N+P + A+ GN V+ K + + + + ++ +++N ++ Sbjct: 179 TAFNFPCAVLGWNACIALVCGNCVVWKGAPTTPLITIAMTKIVASVLEKNNLPGAIFTSF 238 Query: 167 KGGVPETTEL-LKERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDL 225 GG + L R + +TGST G +V + LEL G + V D D+ Sbjct: 239 CGGTEIGQAIALDIRIPLVSFTGSTRAGLMVQQQVSARFGKCLLELSGNNAIIVMDDADI 298 Query: 226 DVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGR 284 +A R + + +GQ C ++ +I +++L + K G+ ++ G Sbjct: 299 QLAVRSVLFAAVGTAGQRCTTCRRLILHENIYQTFLDQLVEVYKQVRIGDPLEKGTLLGP 358 Query: 285 I---INDRHFQRVKGLIDNQ--KVAHGGTWDQS-SRYIAPTILVDVDPQSPVMQEEIFGP 338 + + +F + I +Q K+ GG+ +S ++ PTI V++ P +PV++EE+FGP Sbjct: 359 LHTPASKENFLKGIQTIKSQGGKILFGGSAIESEGNFVQPTI-VEITPSAPVVKEELFGP 417 Query: 339 VMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVP 398 V+ ++ ++L+EAI+ N + L+ +F+ +I K + S + IV++ +P Sbjct: 418 VLYVMKFQTLKEAIEINNSVPQGLSSSIFTKRPDIIFKWLGPHGS-----DCGIVNVNIP 472 Query: 399 T------LPFGGVGNSGMGAYHGKKSFETFSHRRSCLVK 431 T FGG +G G G S++ + R +C + Sbjct: 473 TNGAEIGGAFGGEKATGGGREAGSDSWKQYMRRATCTIN 511 >5TJR-A nrPDB Length = 531 Score = 101 bits (251), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 109/447 (24%), Positives = 186/447 (41%), Gaps = 33/447 (7%) Query: 3 SISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE 62 ++ + A+ AF + + R Q L ++++ N + I ++ + GK Sbjct: 74 TMQQAIDAAKAAFPAWRNTPPAKRAQVLFRFKQLLEANEERIVKLISEEHGKT------- 126 Query: 63 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQD-----DLYIHSEPLGVVLVIGAWNYP 117 + EL I+ + ++A P + ++ D + +P+GVV I +N+P Sbjct: 127 -IEDAAGELKRGIENV-EYATAAPEILKGEYSRNVGPNIDAWSDFQPIGVVAGITPFNFP 184 Query: 118 FNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTEL 176 + + A+A GN ILKPSE L+A L + + + + VV G L Sbjct: 185 AMVPLWMYPLAIACGNTFILKPSERDPSSTLLIAELFHEAGLPKGVLNVVHGDKGAVDAL 244 Query: 177 LKE-RFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWG 235 ++ + + GST + + + + K V G K+ + D DLD A + Sbjct: 245 IEAPEVKALSFVGSTPIAEYIYSEGTKRGKRVQALGGAKNHAVLMPDADLDNAVSALMGA 304 Query: 236 KFMNSGQTCVAPDYILC-DPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQR 293 + + G+ C+A +C I + +V+KL +K G D G ++ + Sbjct: 305 AYGSCGERCMAISVAVCVGDQIADALVQKLVPQIKGLKIGAGTSCGLDMGPLVTGAARDK 364 Query: 294 VKGLIDNQKVAHGGTWDQSSR-----------YIAPTILVDVDPQSPVMQEEIFGPVMPI 342 V G ID VA G R ++ T+ V P+ + +EEIFGPV+ I Sbjct: 365 VTGYIDT-GVAQGAELVVDGRGYKVAGHENGFFLGGTLFDRVTPEMTIYKEEIFGPVLCI 423 Query: 343 VCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPF 402 V V SLEEA+Q IN E +F+ + + + E G V N V + + V F Sbjct: 424 VRVNSLEEAMQLINDHEYGNGTCIFTRDGEAARLFCDEIEVGMVGVN-VPLPVPVAYHSF 482 Query: 403 GGVGNSGMGAYH--GKKSFETFSHRRS 427 GG S G H G ++ R++ Sbjct: 483 GGWKRSLFGDLHAYGPDGVRFYTKRKA 509 >4U3W-A nrPDB Length = 505 Score = 101 bits (251), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 93/349 (26%), Positives = 150/349 (42%), Gaps = 18/349 (5%) Query: 99 YIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY- 157 Y+ +PLGV+ +I WN P L + A+A GN V+ KPSE + A LLA ++ Sbjct: 157 YVTRKPLGVIGIISPWNLPLLLFTWKVAPALAMGNCVVAKPSEETPSSATLLAEVMHDVG 216 Query: 158 MDQNLYLVVKG-GVPETTELLKERFD--HIMYTGSTAVGKIVMAAAAKHLTPVTLELGGK 214 + ++ ++ G G E L D I +TG + G +M A A + V+ ELGGK Sbjct: 217 LPPGVFNLIHGHGQNAAGEFLTRHPDISAITFTGESRTGSTIMKAVADGVKEVSFELGGK 276 Query: 215 SPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YG 273 + V D D D A + F N+GQ C+ + + + I + V LK+ + G Sbjct: 277 NAAVVFADADFDAAVAGVLRSSFTNAGQVCLCSERVYVERPIFERFVAALKEQAQALRVG 336 Query: 274 EDAKQSRDYGRIINDRHFQRVKGLI-----DNQKVAHG------GTWDQSSRYIAPTILV 322 + G +I+ H +V + V G G ++ PTI Sbjct: 337 APEDPATTMGPLISRGHRDKVLSYFRLAVEEGATVVTGGGAPSFGDARDDGAFVMPTIWT 396 Query: 323 DVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETS 382 + + ++EEIFGPV I E ++ +N LA +++ ++ + Sbjct: 397 GLPDSARCVREEIFGPVCHIAPFDDEAEVVKRVNDSAYGLAASIWTTQLARGHRVAKQIE 456 Query: 383 SGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVK 431 +G V N V PFGG SG+G G+ S + +S + V+ Sbjct: 457 TGIVWVNAWFVRDL--RTPFGGTKLSGLGREGGRHSLDFYSELTNVCVR 503 >3ROS-A nrPDB Length = 484 Score = 99.0 bits (245), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 90/329 (27%), Positives = 134/329 (40%), Gaps = 25/329 (7%) Query: 99 YIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLI---- 154 Y + GV++ WN+P I+ GN ++LK + A L A +I Sbjct: 118 YYLKQSTGVIMACEPWNFPLYQVIRVFAPNFIVGNPILLKHAHNVPGSAALTAKIIKRAG 177 Query: 155 -PQYMDQNLYLVVKGGVPETTELLK----ERFDHIMYTGSTAVGKIVMAAAAKHLTPVTL 209 P+ NLY P +L R + TGS G V AA K+L T+ Sbjct: 178 APEGSLINLY-------PSYDQLADIIADPRIQGVALTGSERGGSAVAEAAGKNLKKSTM 230 Query: 210 ELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLK 269 ELGG V D D V + + N GQ C + I+ + S ++++ +LK Sbjct: 231 ELGGNDAFIVLDDADPQVLRNVLNDARTYNDGQVCTSSKRIIVEKSRYDEVLHELKNVFS 290 Query: 270 DFYGEDAKQSRDYGRIINDRHFQ-----RVKGLID-NQKVAHG-GTWDQSSRYIAPTILV 322 + D ++ +N + +VK ID KV + D + PTIL Sbjct: 291 NLKAGDPLEADTTLPPMNSEKAKEKLEAQVKEAIDAGAKVFYQYPEIDSKGAFFRPTILT 350 Query: 323 DVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETS 382 D+ +PV +E+FGP+ + V AIQ N L V ++ KK+ A+ Sbjct: 351 DIAKDNPVFDKEVFGPIAEVFVVEDDNAAIQLANDSSYGLGSSVIGSDIDRAKKVSAQIE 410 Query: 383 SGGVTANDVIVHITVPTLPFGGVGNSGMG 411 +G N IT LPFGG+ SG G Sbjct: 411 TGMTVING--RWITSGELPFGGIKKSGYG 437 >4X0T-A nrPDB Length = 513 Score = 98.6 bits (244), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 99/450 (22%), Positives = 194/450 (43%), Gaps = 40/450 (8%) Query: 6 DTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVA 65 +TVK+AREA+ R + + + + E ++ + ++ ++GK E V Sbjct: 64 ETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGK----ILVEGVG 119 Query: 66 HVLEELDTTIKELPDWAED------EPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFN 119 V E +D + D+A P+ + ++ L P+G+V +I A+N+P Sbjct: 120 EVQEYVD-----ICDYAVGLSRMIGGPILPSERSGHA-LIEQWNPVGLVGIITAFNFPVA 173 Query: 120 LTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQN-----LYLVVKGGVPETT 174 + A+ GN + K + + ++ + +I + ++ N + + GG T Sbjct: 174 VYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGT 233 Query: 175 ELLK-ERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIA 233 + K ER + + +TGST VGK V + LELGG + +D DL + Sbjct: 234 AMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSAL 293 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQ 292 + +GQ C + SI +++V +LKK+ G + YG + + Sbjct: 294 FAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVS 353 Query: 293 RVKGLIDNQK-----VAHGG-TWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVR 346 G ++ K V +GG D+ Y+ PTI+ + + + E F P++ + + Sbjct: 354 MFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFK 413 Query: 347 SLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTL------ 400 + EE + N+ ++ L+ +F+ + I + + S + IV++ +PT Sbjct: 414 NEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGS-----DCGIVNVNIPTSGAEIGG 468 Query: 401 PFGGVGNSGMGAYHGKKSFETFSHRRSCLV 430 FGG ++G G G +++ + R +C + Sbjct: 469 AFGGEKHTGGGRESGSDAWKQYMRRSTCTI 498 >4ZZ7-A nrPDB Length = 501 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 82/348 (23%), Positives = 152/348 (43%), Gaps = 19/348 (5%) Query: 97 DLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQ 156 D + +P+GVV I +N+P + + A+ GN +LKPSE +A L+ + Sbjct: 134 DSWSEFQPMGVVAGITPFNFPVMVPLWMFPMAIVCGNCFVLKPSERDPSSTLYIAQLLQE 193 Query: 157 YMDQNLYLVVKGGVPETTELL--KERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGK 214 + + V G E + L +R + + GST + + + A+ + G K Sbjct: 194 AGLPDGVMNVVNGDKEAVDALLHDDRVKAVSFVGSTPIAEYIYRTASANGKRCQALGGAK 253 Query: 215 SPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDY-ILCDPSIQNQIVEKLKKSLKDF-Y 272 + V D D+D A ++ F +SG+ C+A + + + +V K+ ++++ Sbjct: 254 NHAIVMPDADMDNAVNQLLGAAFGSSGERCMALSVAVAVGDAAGDALVSKMTQAMQKLKV 313 Query: 273 GEDAKQSRDYGRIINDRHFQRVKGLIDNQKVAHGGTWDQSSR-----------YIAPTIL 321 G D+G +I +H ++V G I N G T R ++ T++ Sbjct: 314 GPSTDSGNDFGPVITRQHQEKVIGYI-NSAEQQGATIVVDGRQPKVPNHENGFFVGGTLI 372 Query: 322 VDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAET 381 V P+ QEEIFGPV+ +V V ++++A+ I+ E +F+ + + + Sbjct: 373 DHVTPEMTSYQEEIFGPVLQVVRVATMQDAMDLIDAHEYGNGTCIFTRDGEAARYFSDNI 432 Query: 382 SSGGVTANDVIVHITVPTLPFGGVGNSGMGAYH--GKKSFETFSHRRS 427 G V N + + + V FGG S G H G + ++ R++ Sbjct: 433 QVGMVGIN-IPLPVPVAYHSFGGWKRSLFGDLHAYGPDAVRFYTKRKT 479 >4E4G-A nrPDB Length = 521 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 86/349 (24%), Positives = 152/349 (43%), Gaps = 21/349 (6%) Query: 97 DLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATL-IP 155 D+Y +P+G+ I +N+P + + A+A GNA ILKPSE + LA L I Sbjct: 155 DMYSIRQPVGIGAGITPFNFPGMIPMWMFAPAIACGNAFILKPSERDPSVPIRLAELMIE 214 Query: 156 QYMDQNLYLVVKGGVPETTELLKE-RFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGK 214 + + VV G +L + + GST + + V AA + G K Sbjct: 215 AGLPAGILNVVNGDKGAVDAILTHPDIAAVSFVGSTPIARYVYGTAAMNGKRAQCFGGAK 274 Query: 215 SPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYIL-CDPSIQNQIVEKLKKSLKDF-Y 272 + + D DLD A + + ++G+ C+A + N++++KL ++ Sbjct: 275 NHMIIMPDADLDQAANALIGAGYGSAGERCMAISVAVPVGEETANRLIDKLVPMVESLRI 334 Query: 273 GEDAKQSRDYGRIINDRHFQRVKGLIDN------QKVAHGGTWD----QSSRYIAPTILV 322 G + D G ++ QR++ LID+ + V G + ++ +I + Sbjct: 335 GPYTDEKADMGPVVTKEAEQRIRSLIDSGIEQGAKLVVDGRDFKLQGYENGHFIGGCLFD 394 Query: 323 DVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETS 382 DV P + + EIFGPV+ +V R+ EEA+ + E + +++ + + + + Sbjct: 395 DVTPDMDIYKTEIFGPVLSVVRARNYEEALSLPMKHEYGNGVAIYTRDGDAARDFASRIN 454 Query: 383 SGGVTANDVIVHITVPTL--PFGGVGNSGMGAY--HGKKSFETFSHRRS 427 G V N V I VP FGG +S G HG S + ++ ++ Sbjct: 455 IGMVGVN---VPIPVPLAYHSFGGWKSSSFGDLNQHGTDSIKFWTRTKT 500 >4KNA-A nrPDB Length = 495 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 111/437 (25%), Positives = 183/437 (41%), Gaps = 49/437 (11%) Query: 2 SSISDTVKRA----REAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEW 57 S+ +D V+RA R AF + L R ++ ++ E ++++ + + GK W Sbjct: 42 SASADDVERAVASARRAFAAWSALDLDARCTIVKRFAALLVERKEALATMIGRETGKPLW 101 Query: 58 TSYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYI-HSEPLGVVLVIGAWNY 116 + EVA + ++D +I A E + R D + + P GVV V G +N+ Sbjct: 102 EAR-TEVASMAAKVDISIT-----AYHERTGEKRAPMADGVAVLRHRPHGVVAVFGPYNF 155 Query: 117 PFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNL----YLVVKGGVPE 172 P +L +V A+ AGN V+ KPSE++ +A + + D L +V+G Sbjct: 156 PGHLPNGHIVPALIAGNTVVFKPSELAPGVARATVEI---WRDAGLPAGVLNLVQGEKDT 212 Query: 173 TTELLKER-FDHIMYTGSTAVGKIVMAA-AAKHLTPVTLELGGKSPCYVDKDCDLDVACR 230 L R D + +TGS+ G ++ + + LE+GG +P V + D+D A Sbjct: 213 GVALANHRQIDGLFFTGSSDTGTLLHKQFGGRPEIVLALEMGGNNPLVVAEVEDIDAAVH 272 Query: 231 RIAWGKFMNSGQTCVAPDYILC-DPSIQNQIVEKLKKSLKDFYGE--DAKQSRDYGRIIN 287 F+++GQ C IL + ++ V +L DA G +I+ Sbjct: 273 HAIQSAFLSAGQRCTCARRILVPRGAFGDRFVARLADVASKITASVFDADPQPFMGAVIS 332 Query: 288 DRHFQRVKGLIDNQK--VAHGGT-------WDQSSRYIAPTILVDVDPQSPVMQEEIFGP 338 R R L+ Q V G + D + ++ IL DV + EE FGP Sbjct: 333 ARAASR---LVAAQARLVGLGASPIIEMKQRDPALGFVNAAIL-DVTNVRELPDEEHFGP 388 Query: 339 VMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVP 398 + IV L++AI N L+ + +++E+ +G IV+ P Sbjct: 389 LAQIVRYTDLDDAIARANDTAFGLSAGLLADDEQAWHTFRRAIRAG-------IVNWNRP 441 Query: 399 T------LPFGGVGNSG 409 T PFGG G SG Sbjct: 442 TNGASSAAPFGGAGRSG 458 >6DBB-A nrPDB Length = 511 Score = 77.8 bits (190), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 81/352 (23%), Positives = 153/352 (43%), Gaps = 39/352 (11%) Query: 104 PLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLI--------- 154 P+GV VI A+N+P + A G++V+ KPSE + A L+ Sbjct: 148 PIGVCGVISAFNFPVAVWAWNAALAFVCGDSVVWKPSEKTPLTAIACHVLLQKALREFEK 207 Query: 155 --PQYMDQNLYLVVKGGVPETTELL--KERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLE 210 P L +V G + + E+L ++ + TGS +G+ V ++ L LE Sbjct: 208 THPGVAPAELGQLVLG-MRDVGEVLTASKKVPVVSATGSVRMGQEVAKVLSQRLARGILE 266 Query: 211 LGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKD 270 LGG + V DLD+ R + + +GQ C ++ S+ Q++ +++K+ Sbjct: 267 LGGNNGMIVAPSADLDLVVRAVTFAAVGTAGQRCTTLRRLIVHRSLVEQLLPRIEKAYAS 326 Query: 271 F-YGEDAKQSRDYGRIINDRHFQRV-KGLIDNQKVAHGGTWDQSSR---------YIAPT 319 G ++ G +++ F + K L D ++ GG R Y+ P Sbjct: 327 VKVGNPLEEGTLVGPLVDRASFDAMQKALADARE--QGGEVKGGERVDVGHADAYYVRPA 384 Query: 320 ILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIA 379 I V + QS V++ E F P++ ++ + ++AI N + L+ +F+N+ + ++ ++ Sbjct: 385 I-VRMPKQSAVVERETFAPILYVMVYDNFDDAIDVHNAVPQGLSSAIFTNDMREAEQFMS 443 Query: 380 ETSSGGVTANDVIVHITVPTL------PFGGVGNSGMGAYHGKKSFETFSHR 425 S + IV++ + T FGG +G G G +++ + R Sbjct: 444 AAGS-----DCGIVNVNIGTSGAEIGGAFGGEKETGGGRESGSDAWKAYMRR 490 >3V9H-A nrPDB Length = 566 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 83/321 (25%), Positives = 139/321 (43%), Gaps = 30/321 (9%) Query: 117 PFNLTI--QPMVGAVA-AGNAVILKPSEVSGHMADLLATLIPQY-MDQNL--YLVVKGGV 170 PFN T + GA A GN V+ KPS+ + + + ++ + + N+ ++ G + Sbjct: 212 PFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPL 271 Query: 171 PETTELLKERFDHIMYTGSTAVGKIVMAAAAK-----HLTP-VTLELGGKSPCYVDKDCD 224 T E I +TGS K + A+ H P + E GGK+ +V + D Sbjct: 272 FGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSAD 331 Query: 225 LDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGR 284 ++ F GQ C A + S+ QI +L + D + D+G Sbjct: 332 VESVVSGTLRSAFEYGGQKCSACARLYVPHSLWPQIKGRLLEEHSRIKVGDPAE--DFGT 389 Query: 285 ----IINDRHFQRVKGLIDNQK------VAHGGTWDQSSRY-IAPTILVDVDPQSPVMQE 333 +I+ + F R+K +++ + + GG D S Y + P I+ DPQ P+M+E Sbjct: 390 FFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKE 449 Query: 334 EIFGPVMPIVCV--RSLEEAIQFINQREK-PLALYVFSNNEKVIKKM--IAETSSGGVTA 388 EIFGPV+ + +E +Q ++ L VFS ++ V+++ + ++G Sbjct: 450 EIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYI 509 Query: 389 NDVIVHITVPTLPFGGVGNSG 409 ND V PFGG SG Sbjct: 510 NDKSTGSIVGQQPFGGARASG 530 >4LGZ-A nrPDB Length = 563 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 79/321 (24%), Positives = 137/321 (42%), Gaps = 30/321 (9%) Query: 117 PFNLTI--QPMVGAVA-AGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPE 172 PFN T + GA A GN V+ KPS+ + + + ++ + + N+ V P Sbjct: 209 PFNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPT 268 Query: 173 TTELL--KERFDHIMYTGSTAVGKIVMAAAAKHLTP------VTLELGGKSPCYVDKDCD 224 + + E I +TGS K + A++L + E GGK+ +V D Sbjct: 269 FGDTVTSSEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGGKNFHFVHSSAD 328 Query: 225 LDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGR 284 +D F GQ C A + S+ QI +L + D + D+G Sbjct: 329 VDSVVSGTLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLLEEHSRIKVGDPAE--DFGT 386 Query: 285 ----IINDRHFQRVKGLIDNQK------VAHGGTWDQS-SRYIAPTILVDVDPQSPVMQE 333 +I+ + F R+K +++ + + GG ++S Y+ P I+ DPQ P+M+E Sbjct: 387 FFSAVIDAKAFARIKKWLEHARSSPSLSILAGGQCNESVGYYVEPCIIESKDPQEPIMKE 446 Query: 334 EIFGPVMPIVCV--RSLEEAIQFINQREK-PLALYVFSNNEKVIKKM--IAETSSGGVTA 388 EIFGPV+ + E ++ ++ L VF+ ++ ++++ + ++G Sbjct: 447 EIFGPVLTVYVYPDDKYRETLKLVDSTTSYGLTGAVFAQDKAIVQEATRMLRNAAGNFYI 506 Query: 389 NDVIVHITVPTLPFGGVGNSG 409 ND V PFGG SG Sbjct: 507 NDKSTGSVVGQQPFGGARASG 527 >4OE4-A nrPDB Length = 580 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 96/396 (24%), Positives = 161/396 (40%), Gaps = 48/396 (12%) Query: 53 GKNEWTSYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPL-GVVLVI 111 GKN + + + + + + +K D +PV T Y PL G V + Sbjct: 151 GKNVYQAEIDCITELSDFFRYYVKYASDLYAQQPVESADGTWNKAEY---RPLEGFVYAV 207 Query: 112 GAWNYPFNLTI--QPMVGAVA-AGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVK 167 PFN T ++GA A GN V+ KPS+ + LL T++ + + + + + Sbjct: 208 S----PFNFTAIAANLIGAPALMGNTVVWKPSQTAALSNYLLMTVLEEAGLPKGVINFIP 263 Query: 168 GGVPETTE--LLKERFDHIMYTGSTAV-----GKI---VMAAAAKHLTPVTLELGGKSPC 217 G + T+ L + F + +TGST V GKI V+ + + E GGK+ Sbjct: 264 GDPVQVTDQVLADKDFGALHFTGSTNVFKSLYGKIQSGVVEGKYRDYPRIIGETGGKNFH 323 Query: 218 YVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPS------------IQNQIVEKLK 265 V ++ A G F GQ C A + S +Q+Q V + Sbjct: 324 LVHPSANISHAVLSTIRGTFEFQGQKCSAASRLYLPESKSEEFLSDMFGILQSQNVVPMN 383 Query: 266 KSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQK------VAHGGTWDQS-SRYIAP 318 S G + + G +I+++ F ++ +I++ K + +GG +D+S ++ P Sbjct: 384 TSASPISGGNLRGFM--GPVIHEQSFDKLVKVIEDAKKDPELEILYGGQYDKSQGWFVGP 441 Query: 319 TILVDVDPQSPVMQEEIFGPVMPIVCVRSLE--EAIQFI-NQREKPLALYVFSNNEKVIK 375 T++ P P M E FGP++ + E E I N + L +F+ + K I+ Sbjct: 442 TVIKAKRPDHPYMSTEFFGPILTVYEYPDTEFNEICDIIDNTSQYALTGAIFAKDRKAIE 501 Query: 376 KMIAET--SSGGVTANDVIVHITVPTLPFGGVGNSG 409 + S+G ND V FGG SG Sbjct: 502 YADEKLKFSAGNFYINDKCTGAVVSQQWFGGARMSG 537 >5JFN-A nrPDB Length = 524 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 83/364 (22%), Positives = 150/364 (41%), Gaps = 52/364 (14%) Query: 100 IHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMD 159 + P GV+ I P + +G +AAGN+V+ P + ++ LL LI Q + Sbjct: 183 VEYSPFGVIGAITPTTNPTETIVCNSIGMLAAGNSVVFSPHPRARQVSLLLVRLINQKLA 242 Query: 160 -----QNLYLVVKGGVPETTELLKE--RFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELG 212 +NL + V+ E T + + ++ TG A+ K V++ K + Sbjct: 243 ALGAPENLVVTVEKPSIENTNAMMAHPKVRMLVATGGPAIVKAVLSTGKKAIG----AGA 298 Query: 213 GKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFY 272 G P VD+ +++ A I G ++ VA I+ I + ++ LKK+ Sbjct: 299 GNPPVVVDETANIEKAACDIVNGCSFDNNLPXVAEKEIIAVAQIADYLIFNLKKN----- 353 Query: 273 GEDAKQSRDYGRIINDRHFQRV----KGLIDNQKVAHGGTWDQSSRYIA-----PTILVD 323 A + +D + + Q + KG + V W S I+ IL++ Sbjct: 354 --GAYEIKDPAVL---QQLQDLVLTAKGGPQTKCVGKSAVWLLSQIGISVDASIKIILME 408 Query: 324 VDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSS 383 V + P +QEE+ P++P+V V ++++AI LA+ V +N ++ T Sbjct: 409 VPREHPFVQEELMMPILPLVRVETVDDAID--------LAIEVEHDNRHT--AIMHSTDV 458 Query: 384 GGVTANDVIVHITV-----PTLPFGGVGNSGMGAY-------HGKKSFETFSHRRSCLVK 431 +T ++ T+ P+ G G G + G S ++F+ RR C++ Sbjct: 459 RKLTKMAKLIQTTIFVKNGPSYAGLGAGGEGYSTFTIAGPTGEGLTSAKSFARRRKCVMV 518 Query: 432 SLLN 435 LN Sbjct: 519 EALN 522 >5UJU-A nrPDB Length = 576 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 78/318 (24%), Positives = 123/318 (38%), Gaps = 46/318 (14%) Query: 104 PLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLY 163 P G LV+G +P + +A GN VI+KP H +L I + +++ Sbjct: 204 PRGTGLVLGCCTFPTWNGYPGLFADLATGNTVIVKP-----HPGAILPLAITVRIARDV- 257 Query: 164 LVVKGGVPETTELL---------------KERFDHIMYTGSTAVGKIVMAAAAKHLTPVT 208 L G P LL + I +TGST G + A H V Sbjct: 258 LREAGFDPNVVTLLATEPNDGALVQDLALRPEIKLIDFTGSTQNGTWLERHA--HQAQVY 315 Query: 209 LELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILC---------DPSIQNQ 259 E G + +D DL A + IA+ + SGQ C AP I + ++ Sbjct: 316 TEKAGVNQIVIDSTDDLKAAAKNIAFSLALYSGQMCTAPQNIYVPRDGIRTADGHASFDE 375 Query: 260 IVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKG-------LIDNQKVAHGGTWDQS 312 + + + +++ G+ A+ G I ND R+ L+D+Q + H D Sbjct: 376 VAQAIAGAVQKLTGDPARSVELIGAIQNDGVTARIDAARAVGRVLLDSQTLQHPAFPD-- 433 Query: 313 SRYIAPTIL-VDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQF---INQREKPLALYVFS 368 +R P +L +DV + Q E FGP+ ++ S +++ I L L V+S Sbjct: 434 ARVRTPLVLQLDVADREKFTQ-EWFGPISFVIATDSTAQSLDLAGEIAAEHGALTLSVYS 492 Query: 369 NNEKVIKKMIAETSSGGV 386 + VI GGV Sbjct: 493 TADDVIDAAHEAAVRGGV 510 >5J7I-A nrPDB Length = 488 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 68/327 (20%), Positives = 135/327 (41%), Gaps = 24/327 (7%) Query: 91 RQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLL 150 R+ +++ ++ ++P+G+V I P + I + AV A NA++ P + Sbjct: 117 RRDEENRVWEIAQPVGIVAGIIPSTNPTSTVIFKALIAVKARNAIVFSPHPSAAKCTAEA 176 Query: 151 ATLIPQYMDQN------LYLVVKGGVPETTELLKERF-DHIMYTGSTAVGKIVMAAAAKH 203 A ++ + ++ + + + + T EL+K + D I+ TG G ++ AA Sbjct: 177 ARIMQEAAERAGAPKGLISCITQPTMAATNELMKHKLTDVILATG----GPGLVKAAYSS 232 Query: 204 LTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEK 263 P G P Y+ + ++ A + I K + G C + +L D SI+ ++V + Sbjct: 233 GKPAYGVGPGNVPVYIHESANIAKAVQLIIQSKTFDYGTICASEQALLVDESIKEKVVAE 292 Query: 264 LKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQKVAHGGTWDQSSRYIAPTILVD 323 LK+ F E+ KQ ++N ++ G G S + + Sbjct: 293 LKQQGAYFLNEEEKQKVASIIMVNGSLNAKIVGKAPQVIAEMAGIEIPSDVKLLVAEETE 352 Query: 324 VDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLAL----YVFSNNEKVIKKMIA 379 V + P E++ P++ V+ +EEA + + + L + + +EKVI+ Sbjct: 353 VGKEYPFSIEKL-SPILAFYIVKGMEEASELAQKLLEVGGLGHTVGIHAEDEKVIEAYTI 411 Query: 380 ETSSGGVTANDVIVHITVPTLPFGGVG 406 + +G + N FGG+G Sbjct: 412 DKPAGRIVVN--------AGTTFGGIG 430 >4IDS-A nrPDB Length = 563 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 89/339 (26%), Positives = 130/339 (38%), Gaps = 38/339 (11%) Query: 100 IHSEPL-GVVLVIGAWNY---PFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIP 155 I PL G V I +N+ NL P + GN VI KPS L A L Sbjct: 194 IDYRPLDGFVYAITPFNFTSIAGNLPTAPAL----MGNTVIWKPSITQ----TLAAYLTM 245 Query: 156 QYMDQN------LYLVVKGGVPETTELLKE-RFDHIMYTGSTAV-GKIVMAAAAK----H 203 Q ++ + LV G + L + R I +TGSTA G + H Sbjct: 246 QLLEAAGLPPGVINLVTGDGFAVSDVALADPRLAGIHFTGSTATFGHLWQWVGTNIGRYH 305 Query: 204 LTP-VTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIV- 261 P + E GGK DV + G F GQ C A S+ ++ Sbjct: 306 SYPRLVGETGGKDFVVAHASARPDVLRTALIRGAFDYQGQKCSAVSRAFIAHSVWQRMGD 365 Query: 262 EKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQK------VAHGGTWDQSSRY 315 E L K+ + YG+ S G +I+ R F + I+ K VA GG +D S Y Sbjct: 366 ELLAKAAELRYGDITDLSNYGGALIDQRAFVKNVDAIERAKGAAAVTVAVGGEYDDSEGY 425 Query: 316 -IAPTILVDVDPQSPVMQEEIFGPVMPIVCV--RSLEEAIQFINQREK-PLALYVFSNNE 371 + PT+L+ DP E FGP++ + E+ + I+ + L V +++ Sbjct: 426 FVRPTVLLSDDPTDESFVIEYFGPLLSVHVYPDERYEQILDVIDTGSRYALTGAVIADDR 485 Query: 372 KVIKKMIAET--SSGGVTANDVIVHITVPTLPFGGVGNS 408 + + + ++G ND V PFGG S Sbjct: 486 QAVLTALDRLRFAAGNFYVNDKPTGAVVGRQPFGGARGS 524 >5DBV-A nrPDB Length = 445 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 66/346 (19%), Positives = 133/346 (38%), Gaps = 27/346 (7%) Query: 104 PLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQ--- 160 P GV+ I P I +G +A GN V+ P + ++ LI + Sbjct: 109 PFGVIGAITPCTNPSETIICNTIGMLAGGNTVVFNPHPAAIKTSNFAVQLINEASLSAGG 168 Query: 161 --NLYLVVKGGVPETTELLKERFD--HIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSP 216 N+ V+ ++++++ D I TG V V+ + + + G P Sbjct: 169 PVNIACSVRKPTLDSSKIMMSHQDIPLIAATGGPGVVTAVLQSGKRGIGAG----AGNPP 224 Query: 217 CYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDA 276 VD+ D+ A I G ++ +A ++ +I N+++ + K + Sbjct: 225 VLVDETADIRKAAEDIINGCTFDNNLPAIAEKEVVAIDAIANELMNYMVKEQGCYAITKE 284 Query: 277 KQSRDYGRIINDRHFQRVKGLIDNQKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIF 336 +Q + +I + R D + + D S I+ + + + P++ EE+ Sbjct: 285 QQEKLTNLVITPKGLNRNCVGKDARTLLGMIGIDVPSNI--RCIIFEGEKEHPLISEELM 342 Query: 337 GPVMPIVCVRSLEEAIQFINQREKPLAL-YVFSNNEKVIKKMIAETSSGGVTANDVIVHI 395 P++ IV +S ++A+ EK + L + ++ + K + ++ + I+ Sbjct: 343 MPILGIVRAKSFDDAV------EKAVWLEHGNRHSAHIHSKNVDRITTYAKAIDTAILVK 396 Query: 396 TVPTLPFGGVGNSGMGAY-------HGKKSFETFSHRRSCLVKSLL 434 P+ G G G + G S TF+ RR C++ L Sbjct: 397 NAPSYAAIGFGGEGFCTFTIASRTGEGLTSASTFTKRRRCVMSDSL 442 >1O20-A nrPDB Length = 427 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 94/438 (21%), Positives = 166/438 (37%), Gaps = 78/438 (17%) Query: 1 MSSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 M + + K+ REA++ + + + + + ++ + ++E K I A D+ K Sbjct: 13 MDELLEKAKKVREAWDVLRNATTREKNKAIKKIAEKLDERRKEILEANRIDVEKARERGV 72 Query: 61 YEEVAHVLEELDTTIKELPDWAE-----DEPVAKTRQT--QQDDLYIHSE--PLGVVLVI 111 E + L D I E+ E +PV + + ++D L I P+G + +I Sbjct: 73 KESLVDRLALNDKRIDEMIKACETVIGLKDPVGEVIDSWVREDGLRIARVRVPIGPIGII 132 Query: 112 GAWNYPFNLTIQPMVGAVAAGNAVILKPSE---------VSGHMADLLATLIPQYMDQNL 162 + N+T++ + A+ +GN ++L+ VS L T IP+ + + Sbjct: 133 --YESRPNVTVETTILALKSGNTILLRGGSDALNSNKAIVSAIREALKETEIPESSVEFI 190 Query: 163 YLVVKGGVPETTELLKERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELG-GKSPCYVDK 221 + V E L+E ++ G + V A PV LE G G +VD+ Sbjct: 191 ENTDRSLVLEMIR-LREYLSLVIPRGGYGLISFVRDNAT---VPV-LETGVGNCHIFVDE 245 Query: 222 DCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQ----IVEKLKKSLKDFYGEDAK 277 DL A I K G TC A + +L I + IVE+L+K Sbjct: 246 SADLKKAVPVIINAKTQRPG-TCNAAEKLLVHEKIAKEFLPVIVEELRK----------- 293 Query: 278 QSRDYGRIINDRHFQRVKGLIDNQKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFG 337 H V+G + +R I P ++ + P E Sbjct: 294 ------------HGVEVRGC-------------EKTREIVPDVVPATEDDWPT---EYLD 325 Query: 338 PVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITV 397 ++ I V++++EAI+ I + + + + N KK ++E + V N Sbjct: 326 LIIAIKVVKNVDEAIEHIKKYSTGHSESILTENYSNAKKFVSEIDAAAVYVN-------- 377 Query: 398 PTLPFGGVGNSGMGAYHG 415 + F G G GA G Sbjct: 378 ASTRFTDGGQFGFGAEIG 395 >3V4C-A nrPDB Length = 528 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 65/292 (22%), Positives = 112/292 (38%), Gaps = 37/292 (12%) Query: 84 DEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYP--FNLTIQPMVGAVAAGNAVILKPSE 141 D + + + + ++ + P+G V V GA N+P F+ A+AAG V++K Sbjct: 149 DAAMPERQPAPRQEIRLVQRPVGPVAVFGASNFPLAFSTAGGDTAAALAAGCPVVVKGHS 208 Query: 142 VSGHMADLLATLIPQYMDQ-----NLYLVVKGGVPETTELLKE--RFDHIMYTGSTAVGK 194 +++A + + + ++ +++GG + L + + +TGS A G+ Sbjct: 209 AHPGTGEIVAEAVDAAIRKTGVHPGVFSLIQGGSRDVGHALVQHPHIKAVGFTGSLAGGR 268 Query: 195 IV--MAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWG----KFMNSGQTCVAPD 248 + + AA P ELG +P ++ + L + G M +GQ C P Sbjct: 269 ALFDLCAARPEPIPFFGELGSVNPMFLLPEA-LKARAETLGQGWAGSLTMGAGQFCTNPG 327 Query: 249 YILC-----DPSIQNQIVEKLKKSLKDFYGED--AKQSRDYGRIINDRHFQRVKGLIDNQ 301 + VE L K D AK RD R+ VK L+ + Sbjct: 328 IAVVIEGADADRFTTAAVEALAKVAPQTMLTDGIAKAYRDGQARFATRN--AVKPLLATE 385 Query: 302 KVAHGGTWDQSSRYIAPTILVDVDPQ---SPVMQEEIFGPVMPIVCVRSLEE 350 S R +P + Q + EE+FGP+ +V V S E Sbjct: 386 S---------SGRDASPNLFETTGAQFLADHALGEEVFGPLGLVVRVGSPAE 428 >2Y53-A nrPDB Length = 534 Score = 37.0 bits (84), Expect = 0.016, Method: Compositional matrix adjust. Identities = 78/358 (21%), Positives = 136/358 (37%), Gaps = 49/358 (13%) Query: 59 SYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPF 118 SYY ++ L E + L D E ++K R ++ S GV L I A+N+P Sbjct: 113 SYYAKLGASLGE----VHALRD-GSAESLSKDRSFSAQ--HVLSPTRGVALFINAFNFPS 165 Query: 119 NLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLY----LVVKGGVPETT 174 + A+ +G VI+KP+ + A L ++ +D + L + G + Sbjct: 166 WGLWEKAAPALLSGVPVIVKPATAT---AWLTQRMVADVVDAGILPPGALSIICG--SSA 220 Query: 175 ELLKE--RFDHIMYTGSTAVGKIVMAAAA-----KHLTPVTLELGGKSPCYVDKDCD--- 224 LL + FD + +TGS + A A L L C D D Sbjct: 221 GLLDQIRSFDVVSFTGSADTAATLRAHPAFVQRGARLNVQADSLNSAILC-ADATPDTPA 279 Query: 225 LDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSL-KDFYGEDAKQSRDYG 283 D+ + + + SGQ C A + ++E LK L K G + G Sbjct: 280 FDLFIKEVVREMTVKSGQKCTAIRRAFVPEAALEPVLEALKAKLAKITVGNPRNDAVRMG 339 Query: 284 RIINDRHFQRVKGLIDNQKVAHGGTWDQS-----------SRYIAPTILVDVDPQSPVMQ 332 +++ ++ V I + +D S + +AP + V DP + + Sbjct: 340 SLVSREQYENVLAGIAALREEAVLAYDSSAVPLIDADANIAACVAPHLFVVNDPDNATLL 399 Query: 333 E--EIFGPVMPIVCVR------SLEE--AIQFINQREKPLALYVFSNNEKVIKKMIAE 380 E+FGPV + R +L E A+ + + L ++SN++ + ++ E Sbjct: 400 HDVEVFGPVASVAPYRVTTDTNALPEAHAVALARRGQGSLVASIYSNDDAHLGRLALE 457 >6D97-A nrPDB Length = 547 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 47/182 (25%), Positives = 78/182 (42%), Gaps = 37/182 (20%) Query: 104 PLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILK-PSEVSGHMADLLATL----IPQYM 158 P G V +I +N+P + + ++GA+ GN +LK S+VS M ++ L +P Sbjct: 188 PYGPVAIITPFNFPLEIPLLQLMGALYMGNKPVLKVDSKVSIVMEQMIRLLHDCGLPA-- 245 Query: 159 DQNLYLVVKGGVPETTELLKERFDHIMYTGSTAV---------GKIVMAAAA---KHLTP 206 +++ + G LL+ ++TGS+ V G++ + A K L P Sbjct: 246 -EDMDFINSDGAVMNKLLLEANPKMTLFTGSSRVAEKLAADLKGRVKLEDAGFDWKILGP 304 Query: 207 VTLELGGKSPCYVDKDCDLDV-ACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQ-IVEKL 264 E+ YV CD D AC SGQ C A + + + ++EK+ Sbjct: 305 DVQEVD-----YVAWVCDQDAYAC----------SGQKCSAQSVLFMHKNWSSSGLLEKM 349 Query: 265 KK 266 KK Sbjct: 350 KK 351 >3K9D-A nrPDB Length = 464 Score = 33.9 bits (76), Expect = 0.15, Method: Compositional matrix adjust. Identities = 35/176 (19%), Positives = 70/176 (39%), Gaps = 7/176 (3%) Query: 104 PLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLY 163 PLGVV + P + I + ++ AGN+++ P + +L T+ Sbjct: 108 PLGVVAGLIPSTNPTSTVIYKTLISIKAGNSIVFSPH--PNALKAILETVRIISEAAEKA 165 Query: 164 LVVKGGVPETTELLKERFDHIMYTGSTAV-----GKIVMAAAAKHLTPVTLELGGKSPCY 218 KG + T + D +M TAV G ++ AA TP G P + Sbjct: 166 GCPKGAISCMTVPTIQGTDQLMKHKDTAVILATGGSAMVKAAYSSGTPAIGVGPGNGPAF 225 Query: 219 VDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGE 274 +++ ++ A + I K ++G C + ++ + + ++ + +K F + Sbjct: 226 IERSANIPRAVKHILDSKTFDNGTICASEQSVVVERVNKEAVIAEFRKQGAHFLSD 281 >2H5G-A nrPDB Length = 463 Score = 32.3 bits (72), Expect = 0.49, Method: Compositional matrix adjust. Identities = 46/194 (23%), Positives = 83/194 (42%), Gaps = 29/194 (14%) Query: 89 KTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMAD 148 +TR + +L + P+GV+LVI + + Q A+A+GN ++LK + + H Sbjct: 125 RTRIAKNLELEQVTVPIGVLLVI--FESRPDCLPQVAALAIASGNGLLLKGGKEAAHSNR 182 Query: 149 LLATLIPQYMDQNLYLVVKGGVPETTELLKER------------FDHIMYTGSTAVGKIV 196 +L L + + + GV E +L+ R D I+ GS+ + + + Sbjct: 183 ILHLLTQEALSIH-------GVKEAVQLVNTREEVEDLCRLDKMIDLIIPRGSSQLVRDI 235 Query: 197 MAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKF-----MNSGQTCVAPDYIL 251 AA PV G YVD + +D R + K N+ +T + +L Sbjct: 236 QKAAKG--IPVMGHSEGICHMYVDSEASVDKVTRLVRDSKCEYPAACNALETLLIHRDLL 293 Query: 252 CDPSIQNQIVEKLK 265 P + +QI++ L+ Sbjct: 294 RTP-LFDQIIDMLR 306 >6G4F-A nrPDB Length = 464 Score = 31.6 bits (70), Expect = 0.65, Method: Compositional matrix adjust. Identities = 24/97 (24%), Positives = 44/97 (45%), Gaps = 4/97 (4%) Query: 111 IGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGH---MADLLATLIPQYMDQNLYLVVK 167 +GA + F + P+ AVA N I++ + H M LL + + ++D L ++ Sbjct: 316 LGALGHGFTGSGHPVATAVALENLKIIEEESLVEHAAQMGQLLRSGLQHFIDHPLVGEIR 375 Query: 168 G-GVPETTELLKERFDHIMYTGSTAVGKIVMAAAAKH 203 G G+ EL+ +R Y +G+ + A +H Sbjct: 376 GCGLIAAVELVGDRVSKAPYQALGTLGRYMAGRAQEH 412 >3EDP-A nrPDB Length = 236 Score = 31.6 bits (70), Expect = 0.80, Method: Compositional matrix adjust. Identities = 33/107 (30%), Positives = 45/107 (42%), Gaps = 18/107 (16%) Query: 256 IQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQKVAHGGTWDQSSRY 315 ++N E LKK +KDFY A + Y I + + V + QK HG T D R Sbjct: 89 MKNDTNENLKKDIKDFYIRKA--GKFYAEIFGMKENELVYSIKFVQKSEHGATLD---RL 143 Query: 316 IAPTILVDVDPQSPVMQEEIFGPVMPIVCVRS-------LEEAIQFI 355 I P L P +Q + F + I V S LE+ +Q I Sbjct: 144 ILPLGLY------PDLQAKDFQIINIIELVNSGKYKLFELEQELQLI 184 >5SWI-B nrPDB Length = 717 Score = 28.1 bits (61), Expect = 7.6, Method: Compositional matrix adjust. Identities = 13/26 (50%), Positives = 16/26 (61%) Query: 204 LTPVTLELGGKSPCYVDKDCDLDVAC 229 LTPVT +LGG S + D+D AC Sbjct: 102 LTPVTSQLGGDSLFHRQSSYDIDKAC 127 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1AD3-A nrPDB 584 e-167 3SZA-A nrPDB 565 e-161 5AC2-A nrPDB 547 e-156 5AC0-A nrPDB 544 e-155 4X2Q-A nrPDB 532 e-152 5FHZ-A nrPDB 532 e-151 5L13-A nrPDB 522 e-149 1AG8-A nrPDB 519 e-147 1O9J-A nrPDB 516 e-147 4V3F-A nrPDB 512 e-145 5GT6-A nrPDB 509 e-144 4QGK-A nrPDB 498 e-141 4I8P-A nrPDB 495 e-140 4O6R-A nrPDB 492 e-139 3IWK-A nrPDB 491 e-139 3IWJ-A nrPDB 483 e-137 4PXL-B nrPDB 482 e-136 4PZ2-A nrPDB 481 e-136 6QAO-A nrPDB 475 e-134 4MPY-A nrPDB 474 e-134 4GO4-A nrPDB 473 e-134 4CAZ-A nrPDB 468 e-132 4O5H-A nrPDB 466 e-131 1BPW-A nrPDB 465 e-131 3RHO-A nrPDB 461 e-130 3JZ4-A nrPDB 459 e-129 3R31-A nrPDB 458 e-129 6B4R-B nrPDB 455 e-128 2D4E-A nrPDB 455 e-128 4I8Q-A nrPDB 454 e-128 6C43-A nrPDB 450 e-127 5IUV-A nrPDB 446 e-126 3I44-A nrPDB 446 e-125 4QYJ-A nrPDB 445 e-125 1WNB-A nrPDB 439 e-123 5KLK-A nrPDB 438 e-123 4F3X-A nrPDB 437 e-123 3QAN-A nrPDB 432 e-121 3RJL-A nrPDB 429 e-120 3TY7-A nrPDB 427 e-120 4V6H-A nrPDB 425 e-119 5UR2-A nrPDB 421 e-118 4LIH-A nrPDB 421 e-118 2HG2-A nrPDB 418 e-117 2JG7-A nrPDB 415 e-116 5UCD-A nrPDB 414 e-116 3RHD-A nrPDB 413 e-116 3K2W-A nrPDB 413 e-116 3VZ3-A nrPDB 413 e-116 5EUY-A nrPDB 412 e-115 1T90-A nrPDB 410 e-115 3EK1-A nrPDB 409 e-114 3U4J-A nrPDB 409 e-114 4U3W-A nrPDB 409 e-114 3B4W-A nrPDB 408 e-114 6MVR-A nrPDB 406 e-113 4X0T-A nrPDB 405 e-113 5J77-A nrPDB 405 e-113 6FK3-A nrPDB 405 e-113 4JZ6-A nrPDB 404 e-113 4ZZ7-A nrPDB 403 e-113 4DNG-A nrPDB 400 e-112 3VZ0-A nrPDB 400 e-112 3PRL-A nrPDB 399 e-111 5TJR-A nrPDB 399 e-111 4OGD-A nrPDB 397 e-111 4YWE-A nrPDB 396 e-110 5NNO-A nrPDB 396 e-110 2QE0-A nrPDB 394 e-110 2J5N-A nrPDB 393 e-110 2W8P-A nrPDB 393 e-109 5X5U-A nrPDB 388 e-108 3RH9-A nrPDB 385 e-107 3R64-A nrPDB 383 e-107 3EFV-A nrPDB 382 e-106 5VBF-A nrPDB 378 e-105 3ROS-A nrPDB 377 e-105 5N5S-A nrPDB 375 e-104 5KF0-A nrPDB 375 e-104 4PXN-A nrPDB 373 e-104 5U0M-A nrPDB 371 e-103 5JRY-A nrPDB 369 e-102 4E4G-A nrPDB 365 e-101 5J6B-A nrPDB 361 e-100 3JU8-A nrPDB 356 1e-98 4KNA-A nrPDB 354 6e-98 4H7N-A nrPDB 351 3e-97 6DBB-A nrPDB 348 3e-96 1UXV-A nrPDB 345 2e-95 4I3V-A nrPDB 342 2e-94 3V9H-A nrPDB 324 4e-89 4LGZ-A nrPDB 324 5e-89 4OE4-A nrPDB 305 3e-83 4IDS-A nrPDB 274 4e-74 5DBV-A nrPDB 247 8e-66 1O20-A nrPDB 212 2e-55 5J7I-A nrPDB 205 3e-53 5JFN-A nrPDB 196 2e-50 5UJU-A nrPDB 176 2e-44 Sequences not found previously or not previously below threshold: 3V4C-A nrPDB 166 1e-41 3MY7-A nrPDB 155 3e-38 3K9D-A nrPDB 147 9e-36 2Y53-A nrPDB 143 1e-34 1EZ0-A nrPDB 141 9e-34 6D97-A nrPDB 123 2e-28 4GHK-A nrPDB 117 9e-27 1VLU-A nrPDB 106 3e-23 2H5G-A nrPDB 96 4e-20 4JBE-A nrPDB 94 1e-19 5MMM-i nrPDB 33 0.27 5X8R-i nrPDB 33 0.36 1ZBM-A nrPDB 32 0.61 3OD1-A nrPDB 31 1.2 2R70-A nrPDB 31 1.6 5XHW-A nrPDB 30 1.8 6GKZ-A nrPDB 30 1.8 3DOD-A nrPDB 30 2.2 6C49-A nrPDB 30 2.6 3C3E-A nrPDB 29 3.0 3LOO-A nrPDB 29 3.1 3R11-A nrPDB 29 3.4 5T2K-A nrPDB 29 3.6 5ZZ8-q nrPDB 29 4.3 2OYO-A nrPDB 29 5.0 5KQU-A nrPDB 29 5.2 6DEO-A nrPDB 29 6.2 5WYK-3D nrPDB 28 8.2 3UF0-A nrPDB 28 9.4 >1AD3-A nrPDB Length = 452 Score = 584 bits (1507), Expect = e-167, Method: Composition-based stats. Identities = 451/451 (100%), Positives = 451/451 (100%) Query: 3 SISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE 62 SISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE Sbjct: 2 SISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE 61 Query: 63 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTI 122 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTI Sbjct: 62 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTI 121 Query: 123 QPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLKERFD 182 QPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLKERFD Sbjct: 122 QPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLKERFD 181 Query: 183 HIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQ 242 HIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQ Sbjct: 182 HIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQ 241 Query: 243 TCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQK 302 TCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQK Sbjct: 242 TCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQK 301 Query: 303 VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPL 362 VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPL Sbjct: 302 VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPL 361 Query: 363 ALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETF 422 ALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETF Sbjct: 362 ALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETF 421 Query: 423 SHRRSCLVKSLLNEEAHKARYPPSPAKMPRH 453 SHRRSCLVKSLLNEEAHKARYPPSPAKMPRH Sbjct: 422 SHRRSCLVKSLLNEEAHKARYPPSPAKMPRH 452 >3SZA-A nrPDB Length = 469 Score = 565 bits (1456), Expect = e-161, Method: Composition-based stats. Identities = 371/453 (81%), Positives = 416/453 (91%) Query: 1 MSSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 MS IS+ VKRAR AF+SG+TR LQFRIQQLEALQR+I E + + GALA+DL KNEW +Y Sbjct: 17 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 76 Query: 61 YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNL 120 YEEV +VLEE++ I++LP+WA DEPV KT QTQQD+LYIHSEPLGVVLVIG WNYPFNL Sbjct: 77 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 136 Query: 121 TIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLKER 180 TIQPMVGA+AAGNAV+LKPSE+S +MA LLAT+IPQY+D++LY V+ GGVPETTELLKER Sbjct: 137 TIQPMVGAIAAGNAVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 196 Query: 181 FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNS 240 FDHI+YTGST VGKI+M AAAKHLTPVTLELGGKSPCYVDK+CDLDVACRRIAWGKFMNS Sbjct: 197 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 256 Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDN 300 GQTCVAPDYILCDPSIQNQIVEKLKKSLK+FYGEDAK+SRDYGRII+ RHFQRV GLI+ Sbjct: 257 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 316 Query: 301 QKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREK 360 QKVA+GGT D ++RYIAPTIL DVDPQSPVMQEEIFGPV+PIVCVRSLEEAIQFINQREK Sbjct: 317 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 376 Query: 361 PLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFE 420 PLALY+FS+N+KVIKKMIAETSSGGV ANDVIVHIT+ +LPFGGVGNSGMG+YHGKKSFE Sbjct: 377 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 436 Query: 421 TFSHRRSCLVKSLLNEEAHKARYPPSPAKMPRH 453 TFSHRRSCLV+ L+N+E K RYPPSPAKM +H Sbjct: 437 TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH 469 >5AC2-A nrPDB Length = 501 Score = 547 bits (1409), Expect = e-156, Method: Composition-based stats. Identities = 125/445 (28%), Positives = 206/445 (46%), Gaps = 22/445 (4%) Query: 2 SSISDTVKRAREAFNS---GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWT 58 + VK AR+AF +T R + L L +I + ++ + + GK Sbjct: 58 EDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSN 117 Query: 59 SYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGAWNYP 117 +Y ++A ++ T++ WA D+ +T + Y EP+GV I WN+P Sbjct: 118 AYLNDLAGCIK----TLRYCAGWA-DKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFP 172 Query: 118 FNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTEL 176 + I + A++ GN V++KP+E + A +A+LI + + +V G P Sbjct: 173 LVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAA 232 Query: 177 LKER--FDHIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDCDLDVACRRIA 233 + D + +TGST VGK++ AA K +L VTLELGGKSPC V D DLD A Sbjct: 233 ISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAH 292 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKDFYGEDAKQSRDYGRIINDRHFQ 292 G F + GQ C+A I + SI ++ V + ++++ K G G I+ + Sbjct: 293 HGVFYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYD 352 Query: 293 RVKGLIDNQKV------AHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVR 346 ++ LI++ K GG W ++ PT+ +V + + +EEIFGPV I+ + Sbjct: 353 KILDLIESGKKEGAKLECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFK 412 Query: 347 SLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVG 406 SL++ I+ N L+ VF+ + + + +G V N + PFGG Sbjct: 413 SLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVN--CYGVVSAQCPFGGFK 470 Query: 407 NSGMGAYHGKKSFETFSHRRSCLVK 431 SG G G+ F ++ ++ VK Sbjct: 471 MSGNGRELGEYGFHEYTEVKTVTVK 495 >5AC0-A nrPDB Length = 501 Score = 544 bits (1402), Expect = e-155, Method: Composition-based stats. Identities = 124/445 (27%), Positives = 204/445 (45%), Gaps = 22/445 (4%) Query: 2 SSISDTVKRAREAFNS---GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWT 58 + VK AR+AF +T R + L L +I + ++ A + GK Sbjct: 58 EDVDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLIERDRLLLATMEAMNGGKLFSN 117 Query: 59 SYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGAWNYP 117 +Y ++ ++ T++ WA D+ +T + Y SEP+GV I WN+P Sbjct: 118 AYLMDLGGCIK----TLRYCAGWA-DKIQGRTIPMDGNFFTYTRSEPVGVCGQIIPWNFP 172 Query: 118 FNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTEL 176 + + + A++ GN V++KP+E + A + +LI + + +V G P Sbjct: 173 LLMFLWKIGPALSCGNTVVVKPAEQTPLTALHMGSLIKEAGFPPGVVNIVPGYGPTAGAA 232 Query: 177 LKER--FDHIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDCDLDVACRRIA 233 + D + +TGST VGK++ AA K +L V+LELGGKSPC V D DLD A Sbjct: 233 ISSHMDVDKVAFTGSTEVGKLIKEAAGKSNLKRVSLELGGKSPCIVFADADLDNAVEFAH 292 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFY-GEDAKQSRDYGRIINDRHFQ 292 G F + GQ C+A + + SI ++ V + + K + G G I+ ++ Sbjct: 293 QGVFYHQGQCCIAASRLFVEESIYDEFVRRSVERAKKYVLGNPLTPGVSQGPQIDKEQYE 352 Query: 293 RVKGLIDNQKV------AHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVR 346 ++ LI++ K GG W +I PT+ DV + +EEIFGPV I+ + Sbjct: 353 KILDLIESGKKEGAKLECGGGPWGNKGYFIQPTVFSDVTDDMRIAKEEIFGPVQQIMKFK 412 Query: 347 SLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVG 406 SL++ I+ N L+ +F+N+ + + SG V N + PFGG Sbjct: 413 SLDDVIKRANNTFYGLSAGIFTNDIDKAITVSSALQSGTVWVN--CYSVVSAQCPFGGFK 470 Query: 407 NSGMGAYHGKKSFETFSHRRSCLVK 431 SG G G+ F ++ ++ +K Sbjct: 471 MSGNGRELGEYGFHEYTEVKTVTIK 495 >4X2Q-A nrPDB Length = 504 Score = 532 bits (1372), Expect = e-152, Method: Composition-based stats. Identities = 119/445 (26%), Positives = 199/445 (44%), Gaps = 22/445 (4%) Query: 2 SSISDTVKRAREAFN---SGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWT 58 + I V+ AR AF+ + R + L+ L ++ + ++ + + GK Sbjct: 61 ADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQ 120 Query: 59 SYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGAWNYP 117 ++Y ++ V++ T + WA D+ T D + EP+GV I WN+P Sbjct: 121 AFYVDLQGVIK----TFRYYAGWA-DKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFP 175 Query: 118 FNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTEL 176 + + A+ GN V++KP+E + A + LI + + ++ G P Sbjct: 176 LLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAA 235 Query: 177 LKERF--DHIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDCDLDVACRRIA 233 + D I +TGST VGK++ AA + +L VTLELGGKSP + D DLD A + Sbjct: 236 IASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAH 295 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKD-FYGEDAKQSRDYGRIINDRHFQ 292 G F N GQ C A I + SI + V + + K G + + G I+ + + Sbjct: 296 QGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYN 355 Query: 293 RVKGLI-----DNQKVAHGGTWD-QSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVR 346 ++ LI + K+ GG + +I PT+ +V + +EEIFGPV I+ + Sbjct: 356 KILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFK 415 Query: 347 SLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVG 406 +++E I+ N + L VF+N+ + + +G V N + PFGG Sbjct: 416 TMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWIN--CYNALNAQSPFGGFK 473 Query: 407 NSGMGAYHGKKSFETFSHRRSCLVK 431 SG G G+ +S ++ VK Sbjct: 474 MSGNGREMGEFGLREYSEVKTVTVK 498 >5FHZ-A nrPDB Length = 529 Score = 532 bits (1370), Expect = e-151, Method: Composition-based stats. Identities = 121/444 (27%), Positives = 205/444 (46%), Gaps = 22/444 (4%) Query: 3 SISDTVKRAREAFNS---GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTS 59 + V+ A+ AF + R + L L ++ + +++ D GK + Sbjct: 87 DVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHA 146 Query: 60 YYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDD-LYIHSEPLGVVLVIGAWNYPF 118 ++ ++ + T++ WA D+ KT T + + EP+GV I WN+P Sbjct: 147 FFIDLEGCI----RTLRYFAGWA-DKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPL 201 Query: 119 NLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELL 177 + + + A+ GN ++LKP+E + A L +LI + + +V G P + Sbjct: 202 LMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAI 261 Query: 178 KER--FDHIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDCDLDVACRRIAW 234 + I +TGST VGK+V AA++ +L VTLELGGK+PC V D DLD+A Sbjct: 262 SSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQ 321 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKK-SLKDFYGEDAKQSRDYGRIINDRHFQR 293 G F N GQ C A + + + ++ V + + + K G+ + G I+ + F + Sbjct: 322 GVFFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDK 381 Query: 294 VKGLID-----NQKVAHGGT-WDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRS 347 + LI+ K+ GG+ + +I PT+ +V + +EEIFGPV PI+ +S Sbjct: 382 ILELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKS 441 Query: 348 LEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGN 407 +EE I+ N + L VF+ N K+ + SG V N + PFGG Sbjct: 442 IEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWIN--CYNALYAQAPFGGFKM 499 Query: 408 SGMGAYHGKKSFETFSHRRSCLVK 431 SG G G+ + ++ ++ +K Sbjct: 500 SGNGRELGEYALAEYTEVKTVTIK 523 >5L13-A nrPDB Length = 517 Score = 522 bits (1346), Expect = e-149, Method: Composition-based stats. Identities = 120/445 (26%), Positives = 193/445 (43%), Gaps = 22/445 (4%) Query: 2 SSISDTVKRAREAFNS---GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWT 58 + VK AR AF + R + L L +I + ++ D GK Sbjct: 74 EDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVI 133 Query: 59 SYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGAWNYP 117 SY ++ VL+ ++ WA D+ KT D Y EP+GV I WN+P Sbjct: 134 SYLVDLDMVLK----CLRYYAGWA-DKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFP 188 Query: 118 FNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTEL 176 + + A+A GN V++K +E + A +A LI + + +V G P Sbjct: 189 LLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAA 248 Query: 177 LKER--FDHIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDCDLDVACRRIA 233 + D + +TGST +G+++ AA +L VTLELGGKSP + D D+D A + Sbjct: 249 IASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAH 308 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKDFYGEDAKQSRDYGRIINDRHFQ 292 + F N GQ C A I ++ VE+ + ++ G + G +++ F+ Sbjct: 309 FALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFK 368 Query: 293 RVKGLIDNQK------VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVR 346 ++ G I+ K + GG +I PT+ DV + +EEIFGPVM I+ + Sbjct: 369 KILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFK 428 Query: 347 SLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVG 406 ++EE + N LA VF+ + + +G V N + PFGG Sbjct: 429 TIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVN--CYDVFGAQSPFGGYK 486 Query: 407 NSGMGAYHGKKSFETFSHRRSCLVK 431 SG G G+ + ++ ++ VK Sbjct: 487 MSGSGRELGEYGLQAYTEVKTVTVK 511 >1AG8-A nrPDB Length = 499 Score = 519 bits (1336), Expect = e-147, Method: Composition-based stats. Identities = 121/445 (27%), Positives = 194/445 (43%), Gaps = 22/445 (4%) Query: 2 SSISDTVKRAREAFNS---GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWT 58 + + VK AR AF + R + L L +I + ++ D GK Sbjct: 56 ADVDRAVKAARAAFQLGSPWRRMDASERGRLLNRLADLIERDRTYLAALETLDNGKPYII 115 Query: 59 SYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGAWNYP 117 SY ++ VL+ ++ WA D+ KT D Y EP+GV I WN+P Sbjct: 116 SYLVDLDMVLK----CLRYYAGWA-DKYHGKTIPIDGDYFSYTRHEPVGVCGQIIPWNFP 170 Query: 118 FNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTEL 176 + + A+A GN V++K +E + A +A LI + + V+ G P Sbjct: 171 LLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNVIPGFGPTAGAA 230 Query: 177 LKER--FDHIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDCDLDVACRRIA 233 + D + +TGST VG ++ AA K +L VTLE+GGKSP + D D+D A + Sbjct: 231 IASHEDVDKVAFTGSTEVGHLIQVAAGKSNLKRVTLEIGGKSPNIIMSDADMDWAVEQAH 290 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKDFYGEDAKQSRDYGRIINDRHFQ 292 + F N GQ C A I + VE+ + ++ G + G +++ F+ Sbjct: 291 FALFFNQGQCCCAGSRTFVQEDIYAEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFK 350 Query: 293 RVKGLIDNQK------VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVR 346 +V G I + K + GG +I PT+ D+ + +EEIFGPVM I+ + Sbjct: 351 KVLGYIKSGKEEGLKLLCGGGAAADRGYFIQPTVFGDLQDGMTIAKEEIFGPVMQILKFK 410 Query: 347 SLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVG 406 S+EE + N + LA VF+ + + +G V N + PFGG Sbjct: 411 SMEEVVGRANNSKYGLAAAVFTKDLDKANYLSQALQAGTVWVN--CYDVFGAQSPFGGYK 468 Query: 407 NSGMGAYHGKKSFETFSHRRSCLVK 431 SG G G+ + ++ ++ V+ Sbjct: 469 LSGSGRELGEYGLQAYTEVKTVTVR 493 >1O9J-A nrPDB Length = 501 Score = 516 bits (1330), Expect = e-147, Method: Composition-based stats. Identities = 124/445 (27%), Positives = 198/445 (44%), Gaps = 22/445 (4%) Query: 2 SSISDTVKRAREAFNS---GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWT 58 + VK AREAF +T R Q + L +I + ++ + + GK + Sbjct: 58 EDVDKAVKAAREAFQMGSPWRTMDASERGQLIYKLADLIERDRLLLATLESINAGKVFAS 117 Query: 59 SYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGAWNYP 117 +Y + L+ ++ WA D+ +T + Y EP+GV +I WN P Sbjct: 118 AYLMD----LDYCIKALRYCAGWA-DKIQGRTIPVDGEFFSYTRHEPIGVCGLIFPWNAP 172 Query: 118 FNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTEL 176 L + A+ GN VI+KP+E + A +A+LI + + +V G P Sbjct: 173 MILLACKIGPALCCGNTVIVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAA 232 Query: 177 LKER--FDHIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDCDLDVACRRIA 233 + D + +TGST VGK++ AAAK +L VTLELG K+PC V D DLD A Sbjct: 233 ISSHMDVDKVAFTGSTEVGKMIQEAAAKSNLKRVTLELGAKNPCIVFADADLDSAVEFAH 292 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFY-GEDAKQSRDYGRIINDRHFQ 292 G F N GQ+C+A + + +I ++ V++ + K + G ++G IN Sbjct: 293 QGVFTNQGQSCIAASKLFVEEAIYDEFVQRSVERAKKYVFGNPLTPGVNHGPQINKAQHN 352 Query: 293 RVKGLIDNQKV------AHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVR 346 ++ LI++ K GG W +I PT+ +V + +EEIFGPV I+ + Sbjct: 353 KIMELIESGKKEGAKLECGGGPWGNKGYFIQPTVFSNVTDDMRIAKEEIFGPVQQIMKFK 412 Query: 347 SLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVG 406 SL+E I+ N L VF+ + + + +G V N P GG Sbjct: 413 SLDEVIKRANNTYYGLVAGVFTKDLDKAVTVSSALQAGTVWVN--CYLAASAQSPAGGFK 470 Query: 407 NSGMGAYHGKKSFETFSHRRSCLVK 431 SG G G+ ++ ++ +K Sbjct: 471 MSGHGREMGEYGIHEYTEVKTVTMK 495 >4V3F-A nrPDB Length = 497 Score = 512 bits (1319), Expect = e-145, Method: Composition-based stats. Identities = 127/460 (27%), Positives = 203/460 (44%), Gaps = 23/460 (5%) Query: 2 SSISDTVKRAREAF--NSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTS 59 + V AR AF N+ S R L A+ I E D GK + Sbjct: 45 EDVEVAVVAARRAFRRNNWSATSGAHRATYLRAIAAKITEKKDHFVKLETIDSGKPFDEA 104 Query: 60 Y--YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYP 117 ++VA E + L D + PV T ++ ++ +PLGVV +I WNYP Sbjct: 105 VLDIDDVASCFEYFAGQAEAL-DGKQKAPV--TLPMERFKSHVLRQPLGVVGLISPWNYP 161 Query: 118 FNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQ-YMDQNLYLVVKGGVPETTEL 176 + + A+AAG +LKPSE++ + + + + ++ G P+ Sbjct: 162 LLMATWKIAPALAAGCTAVLKPSELASVTCLEFGEVCNEVGLPPGVLNILTGLGPDAGAP 221 Query: 177 LKER--FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAW 234 L D I +TGS+A G VMA+AA+ + PVTLELGGKSP V +D D+D + Sbjct: 222 LVSHPDVDKIAFTGSSATGSKVMASAAQLVKPVTLELGGKSPIVVFEDVDIDKVVEWTIF 281 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYG-EDAKQSRDYGRIINDRHFQR 293 G F +GQ C A +L SI + V+KL K K+ + ++ G +I+ + + Sbjct: 282 GCFWTNGQICSATSRLLVHESIAAEFVDKLVKWTKNIKISDPFEEGCRLGPVISKGQYDK 341 Query: 294 VKGLI-----DNQKVAHGGTWDQ---SSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCV 345 + I + + +GG+ + YI PTI+ D+ + +EE+FGPV+ + Sbjct: 342 IMKFISTAKSEGATILYGGSRPEHLKKGYYIEPTIVTDISTSMQIWKEEVFGPVLCVKTF 401 Query: 346 RSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGV 405 S +EAI N E LA VFSN+ + +++ G V N P+GG+ Sbjct: 402 SSEDEAIALANDTEYGLAAAVFSNDLERCERITKALEVGAVWVN--CSQPCFVQAPWGGI 459 Query: 406 GNSGMGAYHGKKSFETFSHRRSCLVKSLLNEEAHKARYPP 445 SG G G+ + + + + +++E P Sbjct: 460 KRSGFGRELGEWGIQNYLNIKQVT--QDISDEPWGWYKSP 497 >5GT6-A nrPDB Length = 508 Score = 509 bits (1311), Expect = e-144, Method: Composition-based stats. Identities = 121/443 (27%), Positives = 198/443 (44%), Gaps = 20/443 (4%) Query: 2 SSISDTVKRAREAFNS--GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTS 59 I VK AR AF S + R + L +I E+ + ++ A D GK + Sbjct: 71 EDIDAAVKAARSAFESGPWAEMTTAERAHLIYKLADLIEEHREELAQLEALDNGKPYQVA 130 Query: 60 YYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGAWNYPF 118 ++++ +E + W + + +T +D L Y EP+GVV I WN+P Sbjct: 131 LDDDISATVENY----RYYAGWTT-KIIGQTIPISKDYLNYTRHEPVGVVGQIIPWNFPL 185 Query: 119 NLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELL 177 ++ M A+A G ++LKP+E + A L + + V G PE + Sbjct: 186 VMSSWKMGAALATGCTIVLKPAEQTPLSLLYAAKLFKEAGFPNGVVNFVPGFGPEAGAAI 245 Query: 178 KER--FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWG 235 D + +TGST GK +M +A+ + VTLELGGKSP + +D DL+ A G Sbjct: 246 VNHHDIDKVAFTGSTVTGKYIMRQSAEMIKHVTLELGGKSPNIILEDADLEEAINGAFQG 305 Query: 236 KFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRV 294 N GQ C A + +V+ L K + G ++ + G +++ + +RV Sbjct: 306 IMYNHGQNCSAGSRVFVHRKHYETVVDALVKMANNVKLGAGMEKETEMGPLVSKKQQERV 365 Query: 295 KGLID-----NQKVAHGGTW-DQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSL 348 I+ VA GG + ++ PT+ DV +++EEIFGPV+ ++ S Sbjct: 366 LNYIEQGKKEGATVAAGGERALEKGYFVKPTVFTDVTDDMTIVKEEIFGPVVVVLPFDST 425 Query: 349 EEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNS 408 EE I+ N LA V++ N K ++ + +G V ND ++ PFGG S Sbjct: 426 EEVIERANNSSYGLAAGVWTQNIKTGHQVANKLKAGTVWIND--YNLENAAAPFGGYKQS 483 Query: 409 GMGAYHGKKSFETFSHRRSCLVK 431 G+G G + + ++ +S V Sbjct: 484 GIGRELGSYALDNYTEVKSVWVN 506 >4QGK-A nrPDB Length = 461 Score = 498 bits (1283), Expect = e-141, Method: Composition-based stats. Identities = 290/439 (66%), Positives = 368/439 (83%) Query: 8 VKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHV 67 V+R R+AF SG++R L+FR+QQLEAL+RM+ E K I A+A+DL K+E+ Y +EV V Sbjct: 6 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 65 Query: 68 LEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVG 127 L E+D ++ LP+W +PV K T D+ YI +PLGVVL+IGAWNYPF LTIQP++G Sbjct: 66 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 125 Query: 128 AVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLKERFDHIMYT 187 A+AAGNAVI+KPSE+S + A +LA L+PQY+DQ+LY+V+ GGV ETTELLK+RFDHI YT Sbjct: 126 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 185 Query: 188 GSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAP 247 G+TAVGKIVM AAAKHLTPVTLELGGKSPCY+DKDCDLD+ CRRI WGK+MN GQTC+AP Sbjct: 186 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 245 Query: 248 DYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQKVAHGG 307 DYILC+ S+QNQIV K+K+++K+FYGE+ K+S DY RIIN RHF+R+ L++ QK+A GG Sbjct: 246 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 305 Query: 308 TWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVF 367 D+++RYIAPT+L DVDP++ VMQEEIFGP++PIV V++++EAI FIN+REKPLALYVF Sbjct: 306 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 365 Query: 368 SNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRS 427 S+N K+IK+MI ETSSGGVT NDVI+H T+ + PFGGVG+SGMGAYHGK SF+TFSH+R Sbjct: 366 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 425 Query: 428 CLVKSLLNEEAHKARYPPS 446 CL+KSL E A+K RYPP+ Sbjct: 426 CLLKSLKREGANKLRYPPN 444 >4I8P-A nrPDB Length = 520 Score = 495 bits (1275), Expect = e-140, Method: Composition-based stats. Identities = 116/445 (26%), Positives = 199/445 (44%), Gaps = 21/445 (4%) Query: 16 NSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY--YEEVAHVLEELDT 73 R + L A+ + E ++ A D GK + ++VA E Sbjct: 81 RDWARAPGAVRAKYLRAIAAKVIERKPELAKLEALDCGKPYDEAAWDMDDVAGCFEYFAD 140 Query: 74 TIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGN 133 + L D ++ PV+ +T + ++ EP+GVV +I WNYP + + A+AAG Sbjct: 141 QAEAL-DKRQNSPVSLPMETFK--CHLRREPIGVVGLITPWNYPLLMATWKIAPALAAGC 197 Query: 134 AVILKPSEVSGHMADLLATLIPQ-YMDQNLYLVVKGGVPETTELLKER--FDHIMYTGST 190 +LKPSE++ LA + + + + +V G P+ L D + +TGS Sbjct: 198 TAVLKPSELASVTCLELADICKEVGLPSGVLNIVTGLGPDAGAPLSAHPDVDKVAFTGSF 257 Query: 191 AVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYI 250 GK +MA+AA + PVTLELGGKSP V D D+D A +G F +GQ C A + Sbjct: 258 ETGKKIMASAAPMVKPVTLELGGKSPIVVFDDVDIDKAVEWTLFGCFWTNGQICSATSRL 317 Query: 251 LCDPSIQNQIVEKLKKSLKDFYG-EDAKQSRDYGRIINDRHFQRVKGLIDNQK-----VA 304 L I + E++ K+ + ++ G ++++ ++++K I N K + Sbjct: 318 LIHTKIAKKFNERMVAWAKNIKVSDPLEEGCRLGPVVSEGQYEKIKKFISNAKSQGATIL 377 Query: 305 HGGTWD---QSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKP 361 GG + +I PTI+ D+ + +EE+FGPV+ + + +EAI+ N + Sbjct: 378 TGGVRPAHLEKGFFIEPTIITDITTSMEIWREEVFGPVLCVKEFSTEDEAIELANDTQYG 437 Query: 362 LALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFET 421 LA V S + + +++ E +G + N P+GG SG G G+ + Sbjct: 438 LAGAVISGDRERCQRLSEEIDAGCIWVN--CSQPCFCQAPWGGNKRSGFGRELGEGGIDN 495 Query: 422 FSHRRSCLVKSLLNEEAHKARYPPS 446 + + +++E PS Sbjct: 496 YLSVKQVT--EYISDEPWGWYQSPS 518 >4O6R-A nrPDB Length = 496 Score = 492 bits (1267), Expect = e-139, Method: Composition-based stats. Identities = 123/455 (27%), Positives = 187/455 (41%), Gaps = 22/455 (4%) Query: 3 SISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE 62 + V A AF + R + L L I N ++++ + D G S Sbjct: 49 DVDLAVDAATRAFPAWSAMPAAERGRLLLRLADAIEANTEALAQLESLDTGHPIRDSRAL 108 Query: 63 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGAWNYPFNLT 121 +V + A D+ L Y+ P+GVV I WN+P T Sbjct: 109 DVPRTAA----CFRYFGGMA-DKLQGSVIPVDTGFLNYVQRAPIGVVGQIVPWNFPLMFT 163 Query: 122 IQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQ-YMDQNLYLVVKGGVPETTELLKER 180 M A+AAGN V+LKPSE++ + L+ + + +V G + L E Sbjct: 164 SWKMGPALAAGNTVVLKPSEITPLSTLRIVELMAEVGFPAGVVNIVPGYGHTAGQRLAEH 223 Query: 181 --FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFM 238 I +TGSTA G+ ++ A+ +L V LELGGK V D +LD A AW F Sbjct: 224 PGVGKIAFTGSTATGRRIVEASQGNLKRVQLELGGKGANIVFDDANLDAAINGAAWAIFH 283 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGL 297 N GQ C+A ++ I + +E+ G + + G + + +H RV Sbjct: 284 NQGQACIAGSRLVLHERIADAFLERFVALASSIRIGNPLDPNTEMGPLTSKQHLDRVLSY 343 Query: 298 ID-----NQKVAHGGTWDQ-----SSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRS 347 +D +V GG+ Q + Y+ PTI+ V QEE+FGP + ++ S Sbjct: 344 VDVAREQGGRVLTGGSAPQDPALANGYYVRPTIVEAKHATDRVAQEEVFGPFVTVLRFGS 403 Query: 348 LEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGN 407 +EA+ N E L +++N+ +M A +G N P PFGGVG Sbjct: 404 DDEALAIANATEYGLGSGLWTNDLSRAHRMAARIDAGMCWIN--CYKRVNPGSPFGGVGK 461 Query: 408 SGMGAYHGKKSFETFSHRRSCLVKSLLNEEAHKAR 442 SG G G ++ ++ RS V N H R Sbjct: 462 SGYGREMGFEAMHDYTEARSVWVNVDGNVPPHFKR 496 >3IWK-A nrPDB Length = 503 Score = 491 bits (1265), Expect = e-139, Method: Composition-based stats. Identities = 126/464 (27%), Positives = 204/464 (43%), Gaps = 26/464 (5%) Query: 2 SSISDTVKRAREAFNS-----GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNE 56 + V A+ A + S R + L A+ I E + + D GK Sbjct: 45 EDVDLAVDAAKRAISRKNGRDWSAASGSLRARYLRAIAAKIKEKKDELGKLESIDCGKPL 104 Query: 57 WTSY--YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAW 114 + ++V E +EL D + P++ T + YI EP+GVV +I W Sbjct: 105 EEALADLDDVVACFEYYAGLAEEL-DSKQKAPISLPMDTFKS--YILKEPIGVVALITPW 161 Query: 115 NYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQ-YMDQNLYLVVKGGVPET 173 NYPF + + A+AAG A ILKPSE++ L + + + + + +V G E Sbjct: 162 NYPFLMATWKIAPALAAGCAAILKPSELASVTCLELGEICKEVGLPRGVLNIVTGLGHEA 221 Query: 174 TELLKER--FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRR 231 L D I +TGS+A G +M AA+ + PV+LELGGKSP V +D DLD Sbjct: 222 GASLASHPDVDKISFTGSSATGSKIMTTAAQLVKPVSLELGGKSPIVVFEDVDLDKVAEW 281 Query: 232 IAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYG-EDAKQSRDYGRIINDRH 290 +G F +GQ C A ++ SI + V+KL K ++ + ++ G I+++ Sbjct: 282 TVFGCFFTNGQICSATSRLIVHESIAVEFVDKLVKWAENIKISDPLEEGCRLGPIVSEAQ 341 Query: 291 FQRVKGLI-----DNQKVAHGGTWDQ---SSRYIAPTILVDVDPQSPVMQEEIFGPVMPI 342 +++V I + + GG + ++ PTI+ DV + +EE+FGPV+ + Sbjct: 342 YKKVLNCISSAKSEGATILTGGRRPEHLKKGYFVEPTIITDVTTSMQIWREEVFGPVLAV 401 Query: 343 VCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPF 402 + EEAI N L V SN+ + +++ +G V N + P+ Sbjct: 402 KTFSTEEEAINLANDTHYGLGSAVMSNDLERCERLSKALQAGIVWIN--CAQPSFIQAPW 459 Query: 403 GGVGNSGMGAYHGKKSFETFSHRRSCLVKSLLNEEAHKARYPPS 446 GG+ SG G G+ E + + ++E PPS Sbjct: 460 GGIKRSGFGRELGEWGLENYLSVKQVT--RYTSDEPWGWYQPPS 501 >3IWJ-A nrPDB Length = 503 Score = 483 bits (1245), Expect = e-137, Method: Composition-based stats. Identities = 121/464 (26%), Positives = 208/464 (44%), Gaps = 26/464 (5%) Query: 2 SSISDTVKRAREAF-----NSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNE 56 + V A+ A T S R + L A+ + E ++ + D GK Sbjct: 45 EDVDVAVAAAKTALTRNKGADWATASGAVRARYLRAIAAKVTEKKPELAKLESIDCGKPL 104 Query: 57 WTSY--YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAW 114 + ++VA E ++L D + PV+ T + ++ EP+GVV +I W Sbjct: 105 DEAAWDIDDVAGCFEYYADLAEKL-DARQKAPVSLPMDTFKS--HVLREPIGVVGLITPW 161 Query: 115 NYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQ-YMDQNLYLVVKGGVPET 173 NYP + + A+AAG A ILKPSE++ L + + + + ++ G PE Sbjct: 162 NYPMLMATWKVAPALAAGCAAILKPSELASLTCLELGEICKEVGLPPGVLNILTGLGPEA 221 Query: 174 TELLKER--FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRR 231 L D + +TGS+A G +M AAA+ + PV+LELGGKSP V +D DLD A Sbjct: 222 GAPLATHPDVDKVAFTGSSATGSKIMTAAAQLVKPVSLELGGKSPLVVFEDVDLDKAAEW 281 Query: 232 IAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYG-EDAKQSRDYGRIINDRH 290 +G F +GQ C A ++ SI + + ++ K +K+ + ++ G ++++ Sbjct: 282 AIFGCFWTNGQICSATSRLILHESIATEFLNRIVKWIKNIKISDPLEEGCRLGPVVSEGQ 341 Query: 291 FQRVKGLI-----DNQKVAHGGTWDQ---SSRYIAPTILVDVDPQSPVMQEEIFGPVMPI 342 ++++ + + + GG+ + +I PTI+ DV + +EE+FGPV+ + Sbjct: 342 YEKILKFVSNAKSEGATILTGGSRPEHLKKGFFIEPTIITDVTTNMQIWREEVFGPVLCV 401 Query: 343 VCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPF 402 + EEAI N L V SN+ + +++ +G V N P+ Sbjct: 402 KTFSTEEEAIDLANDTVYGLGAAVISNDLERCERVTKAFKAGIVWVN--CSQPCFTQAPW 459 Query: 403 GGVGNSGMGAYHGKKSFETFSHRRSCLVKSLLNEEAHKARYPPS 446 GGV SG G G+ + + + ++EE PP+ Sbjct: 460 GGVKRSGFGRELGEWGLDNYLSVKQVT--QYISEEPWGWYQPPA 501 >4PXL-B nrPDB Length = 517 Score = 482 bits (1240), Expect = e-136, Method: Composition-based stats. Identities = 128/449 (28%), Positives = 202/449 (44%), Gaps = 20/449 (4%) Query: 2 SSISDTVKRAREAFNS--GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTS 59 + + VK AREAF++ + R + L +I+E+++ ++ D GK Sbjct: 74 ADVDLAVKAAREAFDNGPWPRMTGYERGRILHRFADLIDEHVEELAALDTVDAGKLFAVG 133 Query: 60 YYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFN 119 ++ ++ A+ A + Q+ Y EP+GVV I WNYP Sbjct: 134 KARDIPGAAHL----LRYYAGAADKVHGATLKMAQRMHGYTLKEPVGVVGHIVPWNYPTT 189 Query: 120 LTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLK 178 + + A+AAG AV++KP+E + A A L + + + VV G P + Sbjct: 190 MFFFKVGPALAAGCAVVVKPAEQTPLSALFYAHLAREAGVPAGVLNVVPGFGPTAGAAVA 249 Query: 179 ER--FDHIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDCDLDVACRRIAWG 235 D + +TGST VG++VM AAA+ +L PV+LELGGKSP V D DLD+A + + Sbjct: 250 AHMDVDKVSFTGSTEVGRLVMRAAAESNLKPVSLELGGKSPVIVFDDADLDMAVNLVNFA 309 Query: 236 KFMNSGQTCVAPDYILCDPSIQNQIVEKLKK-SLKDFYGEDAKQSRDYGRIINDRHFQRV 294 + N G+ CVA I I ++ V+K + + K G+ S G ++ +++V Sbjct: 310 TYTNKGEICVAGTRIYVQEGIYDEFVKKAAELASKSVVGDPFNPSVSQGPQVDKDQYEKV 369 Query: 295 KGLI-----DNQKVAHGGT-WDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSL 348 I + + GG YI PTI DV + Q+EIFGPVM ++ +++ Sbjct: 370 LRYIDIGKREGATLVTGGKPCGDKGYYIEPTIFTDVKDDMTIAQDEIFGPVMALMKFKTV 429 Query: 349 EEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNS 408 EE IQ N LA + + N V + +G + N P PFGG S Sbjct: 430 EEVIQKANNTRYGLAAGIVTKNIDVANTVSRSIRAGAIWIN--CYFAFDPDAPFGGYKMS 487 Query: 409 GMGAYHGKKSFETFSHRRSCLVKSLLNEE 437 G G G + + + ++ V L N Sbjct: 488 GFGKDMGMDALDKYLQTKTV-VTPLYNTP 515 >4PZ2-A nrPDB Length = 534 Score = 481 bits (1239), Expect = e-136, Method: Composition-based stats. Identities = 120/454 (26%), Positives = 199/454 (43%), Gaps = 24/454 (5%) Query: 2 SSISDTVKRAREAFNS--GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTS 59 + V+ AR AF+ S R + + L ++ E+ ++ + D GK+ + Sbjct: 88 EDVDLAVRAARAAFDHGEWPRMSGSERGRIMARLADLVEEHAGELAALESLDAGKHPAVT 147 Query: 60 YYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFN 119 +V + +++ A+ + Q + EPLGV VI WN+P Sbjct: 148 RAVDVGNAAG----SLRYFAGAADKIHGETLKMPGQFQGHTLREPLGVAGVIIPWNFPST 203 Query: 120 LTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLK 178 + + A+AAG A+++KP+E + A LA L Q + + VV G P L Sbjct: 204 MFAVKVAPALAAGCALVVKPAEQTPLSALYLAQLAKQAGVPDGVINVVPGFGPTAGAALA 263 Query: 179 ER--FDHIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDCDLDVACRRIAWG 235 D + +TGST VG+++M A+A+ +L PV LELGGKSP V D DLD+A Sbjct: 264 SHMDVDMVSFTGSTEVGRLIMKASAESNLKPVYLELGGKSPLIVFDDADLDMAVELAVGA 323 Query: 236 KFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDA--KQSRDYGRIINDRHFQR 293 F N G+ CVA + + ++ E+L + ++ + D D G ++ ++R Sbjct: 324 SFFNKGEACVAASRVYVQERVYDRFEERLAERMRSWVVGDPFSDPRADQGPQVDKAQYER 383 Query: 294 VKGLI-----DNQKVAHGGTW---DQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCV 345 V I + + GG + YI PT+ +V + +EEIFGPVM ++ Sbjct: 384 VLSYIDHGKREGATLLTGGRPCAPEGKGYYIEPTVFTNVKEDMIIAKEEIFGPVMCLMKF 443 Query: 346 RSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGV 405 +++EEAI N L V + + V +++ +G V N PFGG Sbjct: 444 KTVEEAIARANDTRYGLGAGVVTRDLDVANRVVRSVRAGVVWVN--CYFAMGSDCPFGGR 501 Query: 406 GNSGMGAYHGKKSFETFSHRRSCLVKSLLNEEAH 439 SG G G + + + +S + + L Sbjct: 502 KMSGFGKDEGMHALDKYLAVKSVV--TPLRASPW 533 >6QAO-A nrPDB Length = 508 Score = 475 bits (1223), Expect = e-134, Method: Composition-based stats. Identities = 123/445 (27%), Positives = 203/445 (45%), Gaps = 24/445 (5%) Query: 3 SISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE 62 ++ V+ A+ AF +S R + L R+I E I+ + GK+ + + + Sbjct: 64 EVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLD 123 Query: 63 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTI 122 ++ ++ A + Y EPLGV + IGAWNYPF + Sbjct: 124 -----IDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIAS 178 Query: 123 QPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKERF 181 A+A GNA++ KPS + A LLA + + + L+ VV+GG T + L + Sbjct: 179 WKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGA-ATGQFLCQHP 237 Query: 182 D--HIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMN 239 D + +TGS G +M +AK + PVTLELGGKSP + DCD++ A + F+ Sbjct: 238 DVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLT 297 Query: 240 SGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGLI 298 GQ C + I ++ E++ K + G+ + G +IN H +RV G + Sbjct: 298 QGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFV 357 Query: 299 -----DNQKVAHGGTW-------DQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVR 346 KV GG + Y+ P +L + ++EEIFGPVM I+ Sbjct: 358 KVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFD 417 Query: 347 SLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVG 406 + E ++ N LA VF+ + + +++AE +G N+ +++ LPFGG Sbjct: 418 TEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN--YNVSPVELPFGGYK 475 Query: 407 NSGMGAYHGKKSFETFSHRRSCLVK 431 SG G +G+ + E +S ++ V+ Sbjct: 476 KSGFGRENGRVTIEYYSQLKTVCVE 500 >4MPY-A nrPDB Length = 520 Score = 474 bits (1220), Expect = e-134, Method: Composition-based stats. Identities = 111/449 (24%), Positives = 198/449 (44%), Gaps = 26/449 (5%) Query: 2 SSISDTVKRAREAFNS--GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTS 59 + AR AF S + + R +++ A+ I E+ ++++ D GK S Sbjct: 70 EDAERAILAARRAFESGEWSQETAETRGKKVRAIADKIKEHREALARLETLDTGKTLEES 129 Query: 60 Y--YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYP 117 Y +++ +V + D P+ T + I EP+GVV I WNYP Sbjct: 130 YADMDDIHNVFMYFAGLADKDGGEMIDSPIPDT------ESKIVKEPVGVVTQITPWNYP 183 Query: 118 FNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQ-YMDQNLYLVVKGGVPETTEL 176 + A+A G ++++KPSE++ + L+ + + ++ G E ++ Sbjct: 184 LLQASWKIAPALATGCSLVMKPSEITPLTTIRVFELMEEVGFPKGTINLILGAGSEVGDV 243 Query: 177 LKER--FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAW 234 + D + +TG GK +M AA ++T + LELGGK+P + D D ++A + Sbjct: 244 MSGHKEVDLVSFTGGIETGKHIMKNAANNVTNIALELGGKNPNIIFDDADFELAVDQALN 303 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQR 293 G + ++GQ C A IL SI+++ + L +K G + G +I+ H + Sbjct: 304 GGYFHAGQVCSAGSRILVQNSIKDKFEQALIDRVKKIKLGNGFDADTEMGPVISTEHRNK 363 Query: 294 VKGLI-----DNQKVAHGGTWDQ-----SSRYIAPTILVDVDPQSPVMQEEIFGPVMPIV 343 ++ + + +A GG + PT++ + D ++QEE+FGPV+ + Sbjct: 364 IESYMDVAKAEGATIAVGGKRPDRDDLKDGLFFEPTVITNCDTSMRIVQEEVFGPVVTVE 423 Query: 344 CVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFG 403 + +EAIQ N LA VFS + +++ + G V ND H P+G Sbjct: 424 GFETEQEAIQLANDSIYGLAGAVFSKDIGKAQRVANKLKLGTVWIND--FHPYFAQAPWG 481 Query: 404 GVGNSGMGAYHGKKSFETFSHRRSCLVKS 432 G SG+G GK+ E + + L + Sbjct: 482 GYKQSGIGRELGKEGLEEYLVSKHILTNT 510 >4GO4-A nrPDB Length = 495 Score = 473 bits (1217), Expect = e-134, Method: Composition-based stats. Identities = 121/446 (27%), Positives = 186/446 (41%), Gaps = 23/446 (5%) Query: 12 REAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEEL 71 + AF + R + L L I E + ++ + + G S +V Sbjct: 50 KRAFPAWSALGAAERGRLLLKLADRIEECSEELAQLESLNTGHPIRDSRGLDVPRTAA-- 107 Query: 72 DTTIKELPDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVA 130 + A D+ L Y+ +P+GVV I WN+P T M A+A Sbjct: 108 --CFRYFGGMA-DKIEGSVIPVDAGFLNYVQRKPIGVVAQIVPWNFPLMFTSWKMGPALA 164 Query: 131 AGNAVILKPSEVSGHMADLLATLIPQ-YMDQNLYLVVKGGVPETTELLKERFD--HIMYT 187 AGN +++KPSE++ + L+ + + + VV G + L E D I +T Sbjct: 165 AGNTIVIKPSEITPLSTLRIVELMTEVGFPKGVVNVVPGYGHTAGQALAEHLDVGKIAFT 224 Query: 188 GSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAP 247 GSTA G+ ++ A+ +L + LELGGK V +D +++ A AW F N GQ C+A Sbjct: 225 GSTATGRRIVEASKSNLKRIQLELGGKGANIVFEDANIEAAVNGAAWAIFHNQGQACIAG 284 Query: 248 DYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGLID-----NQ 301 ++ I +Q +E+ K G+ + G + + RV ID Sbjct: 285 SRLILHKDIADQFLERFIALAKSIRLGDPMDPETEMGPLTSALRRDRVLSYIDIAIEQGG 344 Query: 302 KVAHGGTWDQ-----SSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFIN 356 KV GG + Y+ PT++ + PQ V QEE+FGP + +V S EEA+ N Sbjct: 345 KVLAGGKAPDDKALANGFYVEPTVV-EAKPQDRVCQEEVFGPFVTVVRFSSDEEALAIAN 403 Query: 357 QREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGK 416 E L +++ N KM +G N P PFGGVG SG G G Sbjct: 404 NTEYGLGSGLWTQNLARAHKMAHAIHAGMCWIN--CYKRVSPGSPFGGVGQSGYGREMGF 461 Query: 417 KSFETFSHRRSCLVKSLLNEEAHKAR 442 ++ ++ RS V H R Sbjct: 462 EAIHDYTEARSVWVNVDAKIAPHFKR 487 >4CAZ-A nrPDB Length = 490 Score = 468 bits (1205), Expect = e-132, Method: Composition-based stats. Identities = 119/445 (26%), Positives = 195/445 (43%), Gaps = 21/445 (4%) Query: 2 SSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 + V+ A E + R + L ++ E ++ D GK + Sbjct: 44 EDVERAVQSAVEGQKVWAAMTAMQRSRILRRAVDILRERNDELAALETLDTGKPLAETRS 103 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLT 121 ++ + ++ + + +Y EPLGVV IGAWNYP + Sbjct: 104 VDIVTGAD----VLEYYAGLVPAIEGEQIPLRETSFVYTRREPLGVVAGIGAWNYPVQIA 159 Query: 122 IQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKER 180 + A+AAGNA+I KPSEV+ A LA + + + ++ V+ G E + L E Sbjct: 160 LWKSAPALAAGNAMIFKPSEVTPLTALKLAEIYTEAGVPDGVFNVLTGSGREVGQWLTEH 219 Query: 181 --FDHIMYTGSTAVGKIVMAAAAKH-LTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKF 237 + I +TG T+ GK VMA+A+ L VT+ELGGKSP + D DLD A F Sbjct: 220 PLIEKISFTGGTSTGKKVMASASSSSLKEVTMELGGKSPLIIFPDADLDRAADIAVMANF 279 Query: 238 MNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKG 296 +SGQ C + S Q + K+ + ++ G+ ++ ++G +++ H + V G Sbjct: 280 FSSGQVCTNGTRVFIHRSQQARFEAKVLERVQRIRLGDPQDENTNFGPLVSFPHMESVLG 339 Query: 297 LIDNQK-----VAHGGTWD-----QSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVR 346 I++ K + GG Y+APT+ D +++EEIFGPVM I+ Sbjct: 340 YIESGKAQKARLLCGGERVTDGAFGKGAYVAPTVFTDCRDDMTIVREEIFGPVMSILVYD 399 Query: 347 SLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVG 406 +EAI+ N E LA V + + + I +G N + +P GG Sbjct: 400 DEDEAIRRANDTEYGLAAGVVTQDLARAHRAIHRLEAGICWIN--TWGESPAEMPVGGYK 457 Query: 407 NSGMGAYHGKKSFETFSHRRSCLVK 431 SG+G +G + ++ +S V+ Sbjct: 458 QSGVGRENGLTTLAHYTRIKSVQVE 482 >4O5H-A nrPDB Length = 511 Score = 466 bits (1199), Expect = e-131, Method: Composition-based stats. Identities = 115/430 (26%), Positives = 188/430 (43%), Gaps = 22/430 (5%) Query: 18 GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEELDTTIKE 77 +T R + + L +I N + ++ + D GK + +VA + + Sbjct: 86 WRTAKTTDRERLMLVLADLIEANARELAEIESLDNGKPVMVAQGLDVAMAAQ----CFRY 141 Query: 78 LPDWAED------EPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAA 131 + WA + + Y EP+GVV I WN+P + + A+A Sbjct: 142 MAGWATKIEGSVIDAGMPYLPDSEIFAYTRKEPVGVVGAIIPWNFPLLMAAWKIAPALAT 201 Query: 132 GNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELL--KERFDHIMYTG 188 G V+LKP+E + A L LI + +V G L R D I +TG Sbjct: 202 GCTVVLKPAEDTPLSALRLGELIQAAGFPDGVVNIVTGYGHTAGAALSRDPRIDKIAFTG 261 Query: 189 STAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPD 248 ST GK + AA ++T ++LELGGKSP V D DLD A + +A F N GQ C A Sbjct: 262 STQTGKTIGHAALDNMTRMSLELGGKSPVIVLPDVDLDKAAQGVANAIFFNQGQVCTAGS 321 Query: 249 YILCDPSIQNQIVEKLKKSLKDFYGED-AKQSRDYGRIINDRHFQRVKGLIDN------Q 301 + + ++E++ K + G +++ + +RV G ID+ + Sbjct: 322 RAYIHSKVFDGVIERVAKIAASLKIGPGMDPATQIGPLVSAKQRERVCGYIDSGFGEGAR 381 Query: 302 KVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKP 361 A G D ++ PT+LVD V++EEIFGPV+ + ++ A+Q N Sbjct: 382 AAAGGRAIDGPGFFVEPTVLVDTTQAMRVVREEIFGPVLVAMPFDDVDTAVQLANDTPYG 441 Query: 362 LALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFET 421 L ++SN+ I K++ ++G V N + LPFGG+ SG G G+ + Sbjct: 442 LGASIWSNDLSAIHKLVPRIAAGTVWVNCHSL--LDNALPFGGMKQSGFGRELGRAVIDQ 499 Query: 422 FSHRRSCLVK 431 ++ +S ++ Sbjct: 500 YTESKSVMMN 509 >1BPW-A nrPDB Length = 503 Score = 465 bits (1197), Expect = e-131, Method: Composition-based stats. Identities = 120/446 (26%), Positives = 195/446 (43%), Gaps = 24/446 (5%) Query: 2 SSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 + V+ A+ A+ + R + + R+I E +I+ + GK + Y Sbjct: 58 EEVDQAVQSAQAAYLKWSKMAGIERSRVMLEAARIIRERRDNIAKLEVINNGKTITEAEY 117 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLT 121 + ++ I+ A + Y EPLGV I AWNYPF + Sbjct: 118 D-----IDAAWQCIEYYAGLAPTLSGQHIQLPGGAFAYTRREPLGVCAGILAWNYPFMIA 172 Query: 122 IQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKER 180 A+A GNAV+ KPS ++ +LA + + + L VV+GG ET LL Sbjct: 173 AWKCAPALACGNAVVFKPSPMTPVTGVILAEIFHEAGVPVGLVNVVQGGA-ETGSLLCHH 231 Query: 181 --FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFM 238 + +TGS GK VM +AK + VTLELGGKSP + KDC+L+ A R F+ Sbjct: 232 PNVAKVSFTGSVPTGKKVMEMSAKTVKHVTLELGGKSPLLIFKDCELENAVRGALMANFL 291 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGL 297 GQ C + I Q +E++ K K G+ G +I+ +V G Sbjct: 292 TQGQVCTNGTRVFVQREIMPQFLEEVVKRTKAIVVGDPLLTETRMGGLISKPQLDKVLGF 351 Query: 298 I-----DNQKVAHGGTW-------DQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCV 345 + + +V GG ++ +++P +L + ++EEIFGPVM ++ Sbjct: 352 VAQAKKEGARVLCGGEPLTPSDPKLKNGYFMSPCVLDNCRDDMTCVKEEIFGPVMSVLPF 411 Query: 346 RSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGV 405 + EE +Q N LA VF+ + ++ A +G N I+ +PFGG Sbjct: 412 DTEEEVLQRANNTTFGLASGVFTRDISRAHRVAANLEAGTCYIN--TYSISPVEVPFGGY 469 Query: 406 GNSGMGAYHGKKSFETFSHRRSCLVK 431 SG G +G+ + + +S ++ +V+ Sbjct: 470 KMSGFGRENGQATVDYYSQLKTVIVE 495 >3RHO-A nrPDB Length = 517 Score = 461 bits (1187), Expect = e-130, Method: Composition-based stats. Identities = 108/449 (24%), Positives = 201/449 (44%), Gaps = 27/449 (6%) Query: 1 MSSISDTVKRAREAFNS--GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWT 58 +S + V A+EAF + + + R + L L ++ ++ + ++ A D G Sbjct: 73 VSDVDKAVAAAKEAFENGLWGKINARDRGRLLYRLADVMEQHQEELATIEALDAGAVYTL 132 Query: 59 SYYEEVAHVLEELDTTIKELPDWAEDE-----PVAKTRQTQQDDLYIHSEPLGVVLVIGA 113 + V ++ T + W + P+ + R + L EP+GV ++ Sbjct: 133 ALKTHVGMSIQ----TFRYFAGWCDKIQGATIPINQARPNRNLTL-TKKEPVGVCGIVIP 187 Query: 114 WNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATL-IPQYMDQNLYLVVKGGVPE 172 WNYP + +AAGN V++KP++V+ A A L + + + + ++ G Sbjct: 188 WNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNILPGSGSL 247 Query: 173 TTELLKER--FDHIMYTGSTAVGKIVMAAAA-KHLTPVTLELGGKSPCYVDKDCDLDVAC 229 + L + I +TGST VGK +M + A ++ V+L+LGGKSP + DCDL+ A Sbjct: 248 VGQRLSDHPDVRKIGFTGSTEVGKHIMKSCALSNVKKVSLQLGGKSPLIIFADCDLNKAV 307 Query: 230 RRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIIND 288 + F N G+ C+A + + SI NQ V+K+ + ++ G ++ ++G ++ Sbjct: 308 QMGMSSVFFNKGENCIAAGRLFVEESIHNQFVQKVVEEVEKMKIGNPLERDTNHGPQNHE 367 Query: 289 RHFQRV-----KGLIDNQKVAHGG-TWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPI 342 H +++ +G+ + + GG + + PT+ DV+ + +EE FGP+M I Sbjct: 368 AHLRKLVEYCQRGVKEGATLVCGGNQVPRPGFFFQPTVFTDVEDHMYIAKEESFGPIMII 427 Query: 343 VCVR--SLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTL 400 ++ + N E LA VF+ + + + +G V N + T Sbjct: 428 SRFADGDVDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFIN--TYNKTDVAA 485 Query: 401 PFGGVGNSGMGAYHGKKSFETFSHRRSCL 429 PFGG SG G G+ + + ++ Sbjct: 486 PFGGFKQSGFGKDLGEAALNEYLRIKTVT 514 >3JZ4-A nrPDB Length = 481 Score = 459 bits (1182), Expect = e-129, Method: Composition-based stats. Identities = 108/439 (24%), Positives = 188/439 (42%), Gaps = 16/439 (3%) Query: 2 SSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 + A A + + + + R L ++ E+ ++ + + GK + Sbjct: 47 DETRAAIDAANRALPAWRALTAKERATILRNWFNLMMEHQDDLARLMTLEQGKPLAEA-K 105 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLT 121 E+++ ++ +E D L + +P+GV I WN+P + Sbjct: 106 GEISYAASFIEWFAEEGKRIYGDTI---PGHQADKRLIVIKQPIGVTAAITPWNFPAAMI 162 Query: 122 IQPMVGAVAAGNAVILKPSEVSGHMADLLATL-IPQYMDQNLYLVVKGGVPETTELLKER 180 + A+AAG ++LKP+ + A LA L I + ++ VV G L Sbjct: 163 TRKAGPALAAGCTMVLKPASQTPFSALALAELAIRAGVPAGVFNVVTGSAGAVGNELTSN 222 Query: 181 --FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFM 238 + +TGST +G+ +M AK + V+LELGG +P V D DLD A KF Sbjct: 223 PLVRKLSFTGSTEIGRQLMEQCAKDIKKVSLELGGNAPFIVFDDADLDKAVEGALASKFR 282 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGL 297 N+GQTCV + + + ++ EKL++++ G+ G +I+++ +V+ Sbjct: 283 NAGQTCVCANRLYVQDGVYDRFAEKLQQAMSKLHIGDGLDNGVTIGPLIDEKAVAKVEEH 342 Query: 298 I-----DNQKVAHGGTW-DQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEA 351 I +V GG ++ + PTILVDV + V +EE FGP+ P+ + + Sbjct: 343 IADALEKGARVVCGGKAHERGGNFFQPTILVDVPANAKVSKEETFGPLAPLFRFKDEADV 402 Query: 352 IQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMG 411 I N E LA Y ++ + + ++ G V N I+ V PFGG+ SG+G Sbjct: 403 IAQANDTEFGLAAYFYARDLSRVFRVGEALEYGIVGINTGIISNEVA--PFGGIKASGLG 460 Query: 412 AYHGKKSFETFSHRRSCLV 430 K E + + + Sbjct: 461 REGSKYGIEDYLEIKYMCI 479 >3R31-A nrPDB Length = 517 Score = 458 bits (1178), Expect = e-129, Method: Composition-based stats. Identities = 110/448 (24%), Positives = 186/448 (41%), Gaps = 18/448 (4%) Query: 4 ISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEE 63 + + A+ A S R + L+ ++ E ++S D GK + + Sbjct: 54 VERAIASAKRAQKEWAAMSPMARGRILKRAADIMRERNDALSTLETLDTGKPIQETIVAD 113 Query: 64 VAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQ 123 + + A D Y PLGV + IGAWNYP + Sbjct: 114 PTSGADAFEF----FGGIAPSALNGDYIPLGGDFAYTKRVPLGVCVGIGAWNYPQQIACW 169 Query: 124 PMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKE-RF 181 A+ AGNA++ KPSE + A +A ++ + + + L+ V++G L+ Sbjct: 170 KAAPALVAGNAMVFKPSENTPLGALKIAEILIEAGLPKGLFNVIQGDRDTGPLLVNHPDV 229 Query: 182 DHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSG 241 + TGS G+ V AAAA HL VT+ELGGKSP V D D++ A G F +SG Sbjct: 230 AKVSLTGSVPTGRKVAAAAAGHLKHVTMELGGKSPMIVFDDADIESAVGGAMLGNFYSSG 289 Query: 242 QTCVAPDYILCDPSIQNQIVEKLKKSLKD-FYGEDAKQSRDYGRIINDRHFQRVKGLI-- 298 Q C + + + +E LK+ + G+ + G +++ ++V I Sbjct: 290 QVCSNGTRVFVQKKAKARFLENLKRRTEAMILGDPLDYATHLGPLVSKAQQEKVLSYIEK 349 Query: 299 ---DNQKVAHGGTWD----QSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEA 351 + + GG Y+ PT+ DV + +EEIFGPVM ++ +E Sbjct: 350 GKAEGATLITGGGIPNNVAGEGAYVQPTVFADVTDDMTIAREEIFGPVMCVLDFDDEDEV 409 Query: 352 IQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMG 411 + N E LA VF+ + +++ +G + N ++ +PFGG SG G Sbjct: 410 LARANATEFGLAGGVFTADLARAHRVVDGLEAGTLWIN--TYNLCPVEIPFGGSKQSGFG 467 Query: 412 AYHGKKSFETFSHRRSCLVKSLLNEEAH 439 + + E +S ++ V + + + Sbjct: 468 RENSAAALEHYSELKTVYVSTGKVDAPY 495 >6B4R-B nrPDB Length = 497 Score = 455 bits (1171), Expect = e-128, Method: Composition-based stats. Identities = 119/448 (26%), Positives = 200/448 (44%), Gaps = 24/448 (5%) Query: 1 MSSISDTVKRAREAFNS--GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWT 58 ++ VK AR AF+S + R Q + ++ EN + ++ D+GK Sbjct: 56 LADAEQAVKVARNAFDSGAWSRLAPAKRKQTMIRFADLLLENAEELALLETLDMGKPISD 115 Query: 59 SYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGAWNYP 117 S + +VA L + + + D+ + T +L + EP+GVV I WN+P Sbjct: 116 SLHIDVASAANSLRWSAEAI-----DKIYDEVAATPHAELGLVTREPVGVVAAIVPWNFP 170 Query: 118 FNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTEL 176 ++ + A+A GN+VILKPSE S A +A L + + + ++ V+ G + Sbjct: 171 LLMSCWKLGPALATGNSVILKPSEKSPLTAIRIAQLAVEAGIPKGVFNVLPGYGHTVGKA 230 Query: 177 LKER--FDHIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDC-DLDVACRRI 232 L D +++TGST + K +M A + ++ V LE GGKSP V D DL A Sbjct: 231 LALHMDVDTLVFTGSTKIAKQLMVYAGESNMKRVWLEAGGKSPNIVFADAPDLKAAAEAA 290 Query: 233 AWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFY-GEDAKQSRDYGRIINDRHF 291 A N G+ C A +L + SI+++ + + ++LK + G + G +++ + Sbjct: 291 AGAIAFNQGEVCTAGSRLLVERSIKDKFLPLVIEALKGWKPGNPLDPETNVGALVDTQQM 350 Query: 292 QRVKGLID-----NQKVAHGGTW---DQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIV 343 V I+ K+ GG + Y+ PTI V + +EEIFGPV+ ++ Sbjct: 351 NTVLSYIEAGHNDGAKLVAGGKRTLEETGGTYVEPTIFDGVTNAMKIAREEIFGPVLSVI 410 Query: 344 CVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFG 403 EEA++ N LA V+++N +G V N T PFG Sbjct: 411 EFEDAEEAVRIANDTPYGLAAAVWTSNLSKAHLTAKALRAGSVWVNQYDGGDM--TAPFG 468 Query: 404 GVGNSGMGAYHGKKSFETFSHRRSCLVK 431 G SG G +F+ ++ ++ +K Sbjct: 469 GFKQSGNGRDKSLHAFDKYTELKATWIK 496 >2D4E-A nrPDB Length = 515 Score = 455 bits (1171), Expect = e-128, Method: Composition-based stats. Identities = 120/447 (26%), Positives = 193/447 (43%), Gaps = 27/447 (6%) Query: 3 SISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE 62 + K A EAF + R + L + +I ++ ++ D G+ Sbjct: 65 EVDRAAKAAHEAFQRWSRTKAKERKRYLLRIAELIEKHADELAVMECLDAGQVL-RIVRA 123 Query: 63 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLY-IHSEPLGVVLVIGAWNYPFNLT 121 +VA E ++AE +T +D LY P G V +I WN P L+ Sbjct: 124 QVARAAENFAF----YAEYAEHAMEDRTFPVDRDWLYYTVRVPAGPVGIITPWNAPLMLS 179 Query: 122 IQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKER 180 + A+A GN V+LKP+E S A LA ++ + + ++ +V+G E L Sbjct: 180 TWRIAPALAFGNTVVLKPAEWSPFTATKLAEILKEADLPPGVFNLVQGFGEEAGAALVAH 239 Query: 181 --FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFM 238 + TG T GKIVM AA HL ++ ELGGKSP V D DL+ A + + F Sbjct: 240 PLVPLLTLTGETETGKIVMRNAADHLKRLSPELGGKSPALVFADADLERALDAVVFQIFS 299 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGL 297 +G+ C A +L + I V K+ + + G + G +I+ H QRV G Sbjct: 300 FNGERCTASSRLLVEEKIFEDFVGKVVERARAIRVGHPLDPETEVGPLIHPEHLQRVLGY 359 Query: 298 I-----DNQKVAHGGTWDQ---------SSRYIAPTILVDVDPQSPVMQEEIFGPVMPIV 343 + + ++ GG + Y+ PT+ V + + QEEIFGPV+ + Sbjct: 360 VEAGKREGARLLVGGERAKTSFRGEDLSRGNYLLPTVFVG-ENHMKIAQEEIFGPVLVAI 418 Query: 344 CVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFG 403 + EEA++ N + LA YVF+ + + ++ E +G V N V PFG Sbjct: 419 PFKDEEEALRKANDTKYGLAAYVFTRDLERAHRLALELEAGMVYLNSHNVRHLP--TPFG 476 Query: 404 GVGNSGMGAYHGKKSFETFSHRRSCLV 430 GV SG G + + ++ ++ + Sbjct: 477 GVKGSGDRREGGTYALDFYTDLKTIAL 503 >4I8Q-A nrPDB Length = 514 Score = 454 bits (1168), Expect = e-128, Method: Composition-based stats. Identities = 126/461 (27%), Positives = 205/461 (44%), Gaps = 24/461 (5%) Query: 2 SSISDTVKRAREAF--NSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTS 59 + V+ AR+A + + + R + L A+ + E ++ + D GK + S Sbjct: 61 EDVDIAVEAARKAIARDDWGSTTGAQRAKYLRAIAAKVLEKKSVLATLESLDSGKTLYES 120 Query: 60 Y--YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYP 117 ++VA E + L D PV + + Y+ EPLGVV +I WNYP Sbjct: 121 AADMDDVAGCFEYYAGLAEAL-DSRRMTPVNLNSDSYKS--YVLREPLGVVGLITPWNYP 177 Query: 118 FNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQ-YMDQNLYLVVKGGVPETTEL 176 + I + A+AAG A ILKPSE++ L + + + ++ G PE Sbjct: 178 LLMAIWKVAPALAAGCAAILKPSELASITCLELGEICREIGLPSGALNILTGLGPEAGGP 237 Query: 177 LK--ERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCD-LDVACRRIA 233 L D I +TGS G +M AAA+ + PV+L LGGKSP V D D LD+A Sbjct: 238 LASHPHVDKISFTGSGPTGSKIMTAAAQLVKPVSLALGGKSPIVVFDDIDNLDIAAEWTL 297 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYG-EDAKQSRDYGRIINDRHFQ 292 +G F N+GQ C A ++ +I + +++L K K+ + ++ G +++ ++ Sbjct: 298 FGIFANTGQVCSATSRLIVQENIASAFMDRLLKWTKNIKISDPLEEDCKLGPVVSAGQYE 357 Query: 293 RVKGLI-----DNQKVAHGGTWDQ---SSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVC 344 +V I + + GG Q Y+ PTI+ DV+ + +EE+FGPV+ + Sbjct: 358 KVLKFISNAKSEGATILCGGERPQHLKKGYYVQPTIITDVNTSMEIWKEEVFGPVLCVKT 417 Query: 345 VRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGG 404 ++ E+AI+ N + L V S + K ++ +G + N T LP+GG Sbjct: 418 FKTEEQAIELANDTKYGLGAAVMSKDVKRCERFTKAFQTGIIWIN--CSQPTFNELPWGG 475 Query: 405 VGNSGMGAYHGKKSFETFSHRRSCLVKSLLNEEAHKARYPP 445 SG G GK E F + + + E P Sbjct: 476 KKRSGFGRDLGKWGLENFLNIKQVT--EYTSAEPLAFYKSP 514 >6C43-A nrPDB Length = 477 Score = 450 bits (1159), Expect = e-127, Method: Composition-based stats. Identities = 109/431 (25%), Positives = 182/431 (42%), Gaps = 21/431 (4%) Query: 14 AFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLE---E 70 AF + + R + L L I +N + + + GK +E+ +++ Sbjct: 54 AFAEWGQTTPKARAECLLKLADSIEQNALEFARLESQNCGKPLHCVINDEIPAIVDVFRF 113 Query: 71 LDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVA 130 + L A E + + I +P+GVV I WNYP + + A+A Sbjct: 114 FAGAARCLSGLAAGEYL------EGHTSMIRRDPIGVVASIAPWNYPLMMAAWKLAPALA 167 Query: 131 AGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELL--KERFDHIMYTG 188 AGN V++KPSE++ A LA L + V+ G ++L E+ + TG Sbjct: 168 AGNCVVIKPSEITPLTALKLAVLAKDIFPPGVLNVLFGRGQTVGDVLTGHEKVRMVSLTG 227 Query: 189 STAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPD 248 S A G+ ++ A + +ELGGK+P V D DLD + + F N+GQ C A Sbjct: 228 SIATGEHILRHTAPAIKRTHMELGGKAPVIVFDDADLDAVAQGVRTFGFYNAGQDCTAAC 287 Query: 249 YILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGLIDNQK----- 302 I I + +VEKL ++ G +S + G + + H +RV ++ K Sbjct: 288 RIYAQRGIYDALVEKLGNAVSSLKMGAPEDESTELGPLSSLAHLKRVTAAVEEAKALSHI 347 Query: 303 --VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREK 360 + G + Y APT+L D + ++Q E+FGPV+ I ++ +++ N Sbjct: 348 RVITGGSQTEGKGYYFAPTLLADAKQEDAIVQREVFGPVVSITVFDDEDQVLRWANDSRY 407 Query: 361 PLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFE 420 LA V++ + ++ A G N + V +P GG SG G E Sbjct: 408 GLASSVWTQDVGRAHRLSARLQYGCTWINTHF--MLVSEMPHGGQKQSGYGKDMSLYGLE 465 Query: 421 TFSHRRSCLVK 431 ++ R +VK Sbjct: 466 DYTLVRHIMVK 476 >5IUV-A nrPDB Length = 497 Score = 446 bits (1148), Expect = e-126, Method: Composition-based stats. Identities = 116/447 (25%), Positives = 193/447 (43%), Gaps = 24/447 (5%) Query: 2 SSISDTVKRAREAFNS--GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTS 59 + V+ AR AF+S + R + ++ +N + ++ D+GK S Sbjct: 57 ADAQRAVESARSAFDSGAWSRLAPAKRKATMIRFAGLLEQNAEELALLETLDMGKPISDS 116 Query: 60 YYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGAWNYPF 118 ++ L + + + + + T D L + EP+GVV I WN+P Sbjct: 117 LGVDIPGGARALSWSGEAIDKLYD-----EVAATPHDQLGLVTREPVGVVAAIVPWNFPL 171 Query: 119 NLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATL-IPQYMDQNLYLVVKGGVPETTELL 177 + + A++ GN+V+LKPSE S A +A L I + + V+ G + L Sbjct: 172 MMACWKLGPALSTGNSVVLKPSEKSPLTAIRIAQLAIEAGIPAGVLNVLPGYGHTVGKAL 231 Query: 178 KER--FDHIMYTGSTAVGKIVMAAAAK-HLTPVTLELGGKSPCYVDKDC-DLDVACRRIA 233 D +++TGST + K +M A + ++ V LE GGKSP V D DL A A Sbjct: 232 ALHMDVDTVVFTGSTKIAKQLMIYAGESNMKRVWLEAGGKSPNIVFADAPDLQAAADSAA 291 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFY-GEDAKQSRDYGRIINDRHFQ 292 N G+ C A +L + SI+++ + + ++L + G + + G +++ + Sbjct: 292 SAIAFNQGEVCTAGSRLLVERSIKDRFLPMVIEALGTWKPGNPLDPATNVGALVDTQQMN 351 Query: 293 RVKGLI-----DNQKVAHGGTW---DQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVC 344 V I D ++ GG + Y+ PTI V+ + QEEIFGPV+ ++ Sbjct: 352 TVLSYIAAGHTDGARLVAGGKQILQETGGTYVEPTIFDGVNNAMRIAQEEIFGPVLSVLT 411 Query: 345 VRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGG 404 + EEAIQ N LA V++ N +G V N T PFGG Sbjct: 412 FDTAEEAIQIANDTPYGLAAAVWTANLSKAHLTARALRAGSVWVNQYDGGDM--TAPFGG 469 Query: 405 VGNSGMGAYHGKKSFETFSHRRSCLVK 431 SG G +F+ ++ +S +K Sbjct: 470 FKQSGNGRDKSLHAFDKYTELKSTWIK 496 >3I44-A nrPDB Length = 497 Score = 446 bits (1148), Expect = e-125, Method: Composition-based stats. Identities = 110/439 (25%), Positives = 199/439 (45%), Gaps = 21/439 (4%) Query: 3 SISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE 62 + A++AF + KT S R+ +E + + + ++ ++ ++G + Sbjct: 64 DADKAINAAKKAFQTWKTTSPHERLGFVEKILEIYEKRSSDMAKTISMEMGAPIDMALNA 123 Query: 63 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTI 122 + A + IK +++ E + + + +H + +GVV +I WN+P N Sbjct: 124 QTATGSSHIRNFIKAYKEFSFQEALIE----GNEQAILHYDAIGVVGLITPWNWPMNQVT 179 Query: 123 QPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKERF 181 ++ A+ AG ++LKPSE++ A L A ++ + + ++ ++ G L Sbjct: 180 LKVIPALLAGCTMVLKPSEIAPLSAMLFAEILDEAALPSGVFNLINGDGANVGSYLSAHP 239 Query: 182 D--HIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMN 239 D I +TGST GK + A+ L V LELGGK + D D+D A +R F N Sbjct: 240 DLEMISFTGSTRAGKDISKNASNTLKRVCLELGGKGANIIFADADID-ALQRGVRHCFYN 298 Query: 240 SGQTCVAPDYILCDPSIQNQIVEKLKK-SLKDFYGEDAKQSRDYGRIINDRHFQRVKGLI 298 SGQ+C AP +L + +I ++ ++ K + K G + G +++ + +++ LI Sbjct: 299 SGQSCNAPTRMLVEQAIYDKAIKTAKDIAEKTQVGPGHQTGNHIGPVVSKEQYDKIQDLI 358 Query: 299 -----DNQKVAHGGTWD----QSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLE 349 + + GGT + Y+ PT+ DV P + +EEIFGPV+ ++ + + Sbjct: 359 QSGIDEGATLVTGGTGLPMGMERGYYVRPTVFADVKPHMRIFREEIFGPVLSLLPFNTED 418 Query: 350 EAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSG 409 EA+ N E L Y+ S + +++ A+ SG V N H FGGV SG Sbjct: 419 EAVTLANDTEYGLTNYIQSQDRSKCRRIAAQVRSGMVEVNG---HELPGGSYFGGVKFSG 475 Query: 410 MGAYHGKKSFETFSHRRSC 428 G + F ++ Sbjct: 476 RAREGGLWGIKEFLDTKAI 494 >4QYJ-A nrPDB Length = 516 Score = 445 bits (1145), Expect = e-125, Method: Composition-based stats. Identities = 110/450 (24%), Positives = 190/450 (42%), Gaps = 26/450 (5%) Query: 1 MSSISDTVKRAREAF--NSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWT 58 + ++ V+ A ++ + R + L L ++ + ++ + GK Sbjct: 71 VEDVNAAVESAAATLRSDTWRRMPPSARERILLRLADLLEVHGDELARLETLNNGKLLIY 130 Query: 59 SYYEEVAHVLEELDTTIKELPDWAED------EPVAKTRQTQQDDLYIHSEPLGVVLVIG 112 S EV + ++ + WA + + P+GVV I Sbjct: 131 SKLMEVGASAQW----LRYMAGWATKLTGSTLDLSLPLPPEVRSRASTQRVPVGVVAAII 186 Query: 113 AWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVP 171 WN+P + + + A+A GN V+LKP+E + A LA L + + VV G Sbjct: 187 PWNFPLLMAVWKIAPALACGNTVVLKPAEETPLTALRLAELAMEAGLPAGALNVVTGRGE 246 Query: 172 ETTELLKER--FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVAC 229 + L + +TGST VG+I+ +A + L V+LELGGKSP V DCD A Sbjct: 247 TAGDALVRHPKVAKVAFTGSTEVGRIIGSACGRSLKAVSLELGGKSPVIVLADCDPQEAA 306 Query: 230 RRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIIND 288 A F N GQ C A + SI ++++L + G +Q G +++ Sbjct: 307 EGAAAAIFFNHGQVCTAGSRLYVHESIYEDVIQRLAVIGESIVVGSGLEQGVHMGPMVSK 366 Query: 289 RHFQRVKGLI-----DNQKVAHGGTWDQ--SSRYIAPTILVDVD-PQSPVMQEEIFGPVM 340 +H + V I D + GGT ++ PTI + + ++ +E+FGPV+ Sbjct: 367 KHHENVLRHIRNGIEDGADLICGGTEAPCAQGFFVKPTIFANREKKDIRLLSQEVFGPVL 426 Query: 341 PIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTL 400 + E + N+ L +++N+ ++ E +G V N ++ P L Sbjct: 427 VATPFSDIAEVVNEANRSVYGLGASIWTNDLSAALRINDELEAGTVWVNTH--NMVDPNL 484 Query: 401 PFGGVGNSGMGAYHGKKSFETFSHRRSCLV 430 PFGG +SG+G HG + E ++ RS ++ Sbjct: 485 PFGGFKDSGVGREHGAAAIEHYTTTRSLVI 514 >1WNB-A nrPDB Length = 495 Score = 439 bits (1130), Expect = e-123, Method: Composition-based stats. Identities = 104/427 (24%), Positives = 183/427 (42%), Gaps = 21/427 (4%) Query: 18 GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLE---ELDTT 74 + + R + L L +I EN + + + + GK +++ +E+ +++ Sbjct: 76 WGQTTPKVRAECLLKLADVIEENGQVFAELESRNCGKPLHSAFNDEIPAIVDVFRFFAGA 135 Query: 75 IKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNA 134 + L A E + + I +PLGVV I WNYP + + A+AAGN Sbjct: 136 ARCLNGLAAGEYL------EGHTSMIRRDPLGVVASIAPWNYPLMMAAWKLAPALAAGNC 189 Query: 135 VILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELL--KERFDHIMYTGSTAV 192 V+LKPSE++ A LA L + ++ G + L + + TGS A Sbjct: 190 VVLKPSEITPLTALKLAELAKDIFPAGVVNILFGRGKTVGDPLTGHPKVRMVSLTGSIAT 249 Query: 193 GKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILC 252 G+ +++ A + +ELGGK+P V D D++ + + N+GQ C A I Sbjct: 250 GEHIISHTASSIKRTHMELGGKAPVIVFDDADIEAVVEGVRTFGYYNAGQDCTAACRIYA 309 Query: 253 DPSIQNQIVEKLKKSLKDFY-GEDAKQSRDYGRIINDRHFQRVKGLIDNQK-------VA 304 I + +VEKL ++ G +S + G + + H +RV ++ K + Sbjct: 310 QKGIYDTLVEKLGAAVATLKSGAPDDESTELGPLSSLAHLERVGKAVEEAKATGHIKVIT 369 Query: 305 HGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLAL 364 G + Y APT+L ++Q+E+FGPV+ + + E+ + + N + LA Sbjct: 370 GGEKRKGNGYYYAPTLLAGALQDDAIVQKEVFGPVVSVTPFDNEEQVVNWANDSQYGLAS 429 Query: 365 YVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSH 424 V++ + ++ A G N + V +P GG SG G E ++ Sbjct: 430 SVWTKDVGRAHRVSARLQYGCTWVNTHF--MLVSEMPHGGQKLSGYGKDMSLYGLEDYTV 487 Query: 425 RRSCLVK 431 R +VK Sbjct: 488 VRHVMVK 494 >5KLK-A nrPDB Length = 520 Score = 438 bits (1128), Expect = e-123, Method: Composition-based stats. Identities = 109/446 (24%), Positives = 180/446 (40%), Gaps = 19/446 (4%) Query: 3 SISDTVKRAREAFNS-GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 +++ V A+ A S+Q R + + I + A +D G+ + Sbjct: 76 QVNEAVVAAQNALKGPWGKLSVQDRAALIHKIADGIQARFEEFVAAEVADTGRPVHQART 135 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLT 121 ++ + T D T Y +PLGV+ VI W+ P L Sbjct: 136 LDIPRAIANFRTFADLAKTSHTDLFEMSTSDGSGALNYTVRKPLGVIGVISPWDLPLLLF 195 Query: 122 IQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGV-PETTELLKE 179 + A+A GN V+ KPSE S A LLA ++ + ++ ++ G E L + Sbjct: 196 TWKVAPALACGNTVVAKPSEESPSSATLLAEVMHDAGVPPGVFNLIHGFGKDSAGEFLTQ 255 Query: 180 R--FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKF 237 + +TG + G +M A A + V+ ELGGK+ V D DLD A + F Sbjct: 256 HPGISALTFTGESKTGSTIMKAVADGVKEVSFELGGKNAAVVFADADLDAAIEGVLRSSF 315 Query: 238 MNSGQTCVAPDYILCDPSIQNQIVEKL-KKSLKDFYGEDAKQSRDYGRIINDRHFQRVKG 296 NSGQ C+ + + SI ++ V L ++ + G + + G +I+ H +V Sbjct: 316 TNSGQVCLCSERVYVHRSIFDEFVSGLKVEAERLVVGYPDQDGVNMGPLISHGHRDKVLS 375 Query: 297 LI-----DNQKVAHGGTWD------QSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCV 345 + V GG Y+ PTI + ++ + EEIFGPV I Sbjct: 376 YYRLAVDEGATVVTGGGVPKFNDERDQGAYVQPTIWTGLSDKARCVTEEIFGPVCHISPF 435 Query: 346 RSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGV 405 +E I +N LA +++ N ++ + G V N ++ PFGGV Sbjct: 436 DDEDEVINRVNDSNYGLACAIWTTNLSRAHRVSRQIHVGLVWVN--TWYLRDLRTPFGGV 493 Query: 406 GNSGMGAYHGKKSFETFSHRRSCLVK 431 SG+G G+ S + +S + +K Sbjct: 494 KLSGLGREGGRFSMDFYSDIANICIK 519 >4F3X-A nrPDB Length = 498 Score = 437 bits (1123), Expect = e-123, Method: Composition-based stats. Identities = 104/443 (23%), Positives = 176/443 (39%), Gaps = 21/443 (4%) Query: 2 SSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 + I V A AF + R L + I + + A + GK Sbjct: 62 AQIDAAVDAAERAFVGWSQTTPAERSNALLKIADAIEKEADEFAALEALNCGKPINAVKN 121 Query: 62 EEVAHVLE---ELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPF 118 +E+ +++ ++ L A E + I +P+G+V I WNYP Sbjct: 122 DELPAIIDCWRFFAGAVRNLHAPAAGEYLP------GHTSMIRRDPIGIVGSIAPWNYPL 175 Query: 119 NLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLK 178 + + A+ GN V+ KPSE + A LA LI + + + V+ G L Sbjct: 176 MMMAWKLAPAIGGGNTVVFKPSEQTPLTALKLARLIADILPEGVVNVITGRGETVGNALI 235 Query: 179 ER--FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGK 236 + TG A GK V+AAAAK + LELGGK+P V D DL+ I Sbjct: 236 NHPKVGMVSITGDIATGKKVLAAAAKTVKRTHLELGGKAPVIVYGDADLEAVVNGIRTFG 295 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVK 295 + N+GQ C A I + I ++V L ++ Y D + G +I+ R RV Sbjct: 296 YYNAGQDCTAACRIYAEAGIYEKLVADLTSAVSTIRYNLDDDTENEIGPLISRRQRDRVA 355 Query: 296 GLIDNQK------VAHGG-TWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSL 348 ++ + GG T + PT++ + +++ E+FGPV+ + Sbjct: 356 SFVERAADQKHIEITTGGRTGSDEGFFFQPTVVAGATQEDEIVRREVFGPVVSVTRFTGK 415 Query: 349 EEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNS 408 ++A+ + N + LA V++ + + + G N + +P GG+ S Sbjct: 416 DDAVAWANDSDYGLASSVWTKDISKAMRAASRLQYGCTWINTHF--MLTNEMPHGGIKQS 473 Query: 409 GMGAYHGKKSFETFSHRRSCLVK 431 G G + E ++ R ++ Sbjct: 474 GYGKDMSVYALEDYTAVRHIMIN 496 >3QAN-A nrPDB Length = 538 Score = 432 bits (1111), Expect = e-121, Method: Composition-based stats. Identities = 109/440 (24%), Positives = 186/440 (42%), Gaps = 20/440 (4%) Query: 5 SDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEV 64 ++ A EAF + + + + R L +I S L + GK W + Sbjct: 77 EKAIQSADEAFQTWRNVNPEERANILVKAAAIIRRRKHEFSAWLVHEAGKP-WKEADADT 135 Query: 65 AHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQP 124 A ++ L+ +++ + + + Q Y P+GV + I WN+ + + Sbjct: 136 AEAIDFLEYYARQMIELNRGKEILSRPGEQNRYFYT---PMGVTVTISPWNFALAIMVGT 192 Query: 125 MVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKERFD- 182 V + GN V+LKP+ + +A ++ + + + V G E + L + Sbjct: 193 AVAPIVTGNTVVLKPASTTPVVAAKFVEVLEDAGLPKGVINYVPGSGAEVGDYLVDHPKT 252 Query: 183 -HIMYTGSTAVGKIVMAAAA------KHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWG 235 I +TGS VG + AA HL V +E+GGK VD+D DLD+A I Sbjct: 253 SLITFTGSKDVGVRLYERAAVVRPGQNHLKRVIVEMGGKDTVVVDRDADLDLAAESILVS 312 Query: 236 KFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRV 294 F SGQ C A + + ++++EK K+ G+ + G +I+++ F+++ Sbjct: 313 AFGFSGQKCSAGSRAVIHKDVYDEVLEKTVALAKNLTVGDPTNRDNYMGPVIDEKAFEKI 372 Query: 295 KGLID----NQKVAHGGTWDQS-SRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLE 349 I+ ++ GG D S +I PTI+ D+DP++ +MQEEIFGPV+ + Sbjct: 373 MSYIEIGKKEGRLMTGGEGDSSTGFFIQPTIIADLDPEAVIMQEEIFGPVVAFSKANDFD 432 Query: 350 EAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSG 409 A++ N E L V + N I++ E G + N V PFGG SG Sbjct: 433 HALEIANNTEYGLTGAVITRNRAHIEQAKREFHVGNLYFNRNCTGAIVGYHPFGGFKMSG 492 Query: 410 MGAY-HGKKSFETFSHRRSC 428 + G ++ Sbjct: 493 TDSKAGGPDYLALHMQAKTV 512 >3RJL-A nrPDB Length = 538 Score = 429 bits (1103), Expect = e-120, Method: Composition-based stats. Identities = 110/440 (25%), Positives = 189/440 (42%), Gaps = 20/440 (4%) Query: 5 SDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEV 64 ++ A +AF + + + R L + S L + GK W + Sbjct: 77 EKAIQAAAKAFETWRYTDPEERAAVLFRAVAKVRRKKHEFSALLVKEAGKP-WNEADADT 135 Query: 65 AHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQP 124 A ++ ++ +++ + A+ +PV + +Y P GV +VI WN+ F + Sbjct: 136 AEAIDFMEYYARQMIELAKGKPVNSREGERNQYVYT---PTGVTVVIPPWNFLFAIMAGT 192 Query: 125 MVGAVAAGNAVILKPSEVSGHMADLLATLIPQ-YMDQNLYLVVKGGVPETTELLKERFD- 182 V + GN V+LKP+ + +A ++ + + + + V G E + L + Sbjct: 193 TVAPIVTGNTVVLKPASAAPVIAAKFVEVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKT 252 Query: 183 -HIMYTGSTAVGKIVMAAAAK------HLTPVTLELGGKSPCYVDKDCDLDVACRRIAWG 235 I +TGS VG + AAK HL V E+GGK VD+DCD+++A + I Sbjct: 253 SIITFTGSREVGTRIFERAAKVQPGQTHLKQVIAEMGGKDTVVVDEDCDIELAAQSIFTS 312 Query: 236 KFMNSGQTCVAPDYILCDPSIQNQIVEKLKK-SLKDFYGEDAKQSRDYGRIINDRHFQRV 294 F +GQ C A + + +++++++ + + GE G +I+ F ++ Sbjct: 313 AFGFAGQKCSAGSRAVVHEKVYDEVLKRVIEITESKKVGEPDSADVYMGPVIDQASFNKI 372 Query: 295 KGLID----NQKVAHGGTWDQS-SRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLE 349 I+ ++ GG D S +I PTI D+DP++ +MQEEIFGPV+ V S + Sbjct: 373 MDYIEIGKEEGRLVSGGKGDDSKGYFIEPTIFADLDPKARLMQEEIFGPVVAFSKVSSFD 432 Query: 350 EAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSG 409 EA++ N E L V + N I + E G + N V PFGG SG Sbjct: 433 EALEVANNTEYGLTGAVITKNRDHINRAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSG 492 Query: 410 MGAY-HGKKSFETFSHRRSC 428 + G ++ Sbjct: 493 TDSKAGGPDYLALHMQAKTI 512 >3TY7-A nrPDB Length = 478 Score = 427 bits (1099), Expect = e-120, Method: Composition-based stats. Identities = 121/440 (27%), Positives = 195/440 (44%), Gaps = 24/440 (5%) Query: 2 SSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 + + V+ A + + + S++ R L+ + + I A+ +LG S Sbjct: 45 ADVDKAVEAADDVYLEFRHTSVKERQALLDKIVKEYENRKDDIVQAITDELGAPLSLSER 104 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLT 121 L L ++ +E ++ D + E +GV +I WN+P N T Sbjct: 105 VHYQMGLNHFVAARDALDNYEFEE--------RRGDDLVVKEAIGVSGLITPWNFPTNQT 156 Query: 122 IQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQ-YMDQNLYLVVKGGVPETTELLKER 180 + A AAG+ V+LKPSE + A +LA + + + + ++ +V G L E Sbjct: 157 SLKLAAAFAAGSPVVLKPSEETPFAAVILAEIFDKVGVPKGVFNLVNGDGAGVGNPLSEH 216 Query: 181 --FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFM 238 + +TGS G +M AAK V+LELGGKSP V D D+ A + Sbjct: 217 PKVRMMSFTGSGPTGSKIMEKAAKDFKKVSLELGGKSPYIVLDDVDIKEAAKATTGKVVN 276 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGL 297 N+GQ C A +L I++ + +LK+ G + G II+ + F +V+ Sbjct: 277 NTGQVCTAGTRVLVPNKIKDAFLAELKEQFSQVRVGNPREDGTQVGPIISKKQFDQVQNY 336 Query: 298 I-----DNQKVAHGG----TWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSL 348 I + ++ +GG + + PTI ++VD Q + QEEIFGPVM ++ L Sbjct: 337 INKGIEEGAELFYGGPGKPEGLEKGYFARPTIFINVDNQMTIAQEEIFGPVMSVITYNDL 396 Query: 349 EEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNS 408 +EAIQ N + LA YV +++ + K+ +G V N+ P LPFGG S Sbjct: 397 DEAIQIANDTKYGLAGYVIGKDKETLHKVARSIEAGTVEINEA---GRKPDLPFGGYKQS 453 Query: 409 GMGAYHGKKSFETFSHRRSC 428 G+G G E F +S Sbjct: 454 GLGREWGDYGIEEFLEVKSI 473 >4V6H-A nrPDB Length = 484 Score = 425 bits (1093), Expect = e-119, Method: Composition-based stats. Identities = 106/423 (25%), Positives = 184/423 (43%), Gaps = 16/423 (3%) Query: 18 GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEELDTTIKE 77 + ++ + R L ++ N ++ L ++ GK + E+A+ ++ +E Sbjct: 66 WRMKTAKERAAILRRWFDLVIANSDDLALILTTEQGKPLAEA-KGEIAYAASFIEWFAEE 124 Query: 78 LPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVIL 137 A D + + EP+GV I WN+P + + + A+AAG +++ Sbjct: 125 GKRVAGDT---LPTPDANKRIVVVKEPIGVCAAITPWNFPAAMIARKVGPALAAGCPIVV 181 Query: 138 KPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKER--FDHIMYTGSTAVGK 194 KP+E + A +A L + + + + VV G + + +TGSTAVG+ Sbjct: 182 KPAESTPFSALAMAFLAERAGVPKGVLSVVIGDPKAIGTEITSNPIVRKLSFTGSTAVGR 241 Query: 195 IVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDP 254 ++MA +A + +TLELGG +P V D DLD A K+ N+GQTCV + Sbjct: 242 LLMAQSAPTVKKLTLELGGNAPFIVFDDADLDAAVEGAIASKYRNNGQTCVCTNRFFVHE 301 Query: 255 SIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGLI-----DNQKVAHGGT 308 + + +KL ++ G + G +IN+ ++V+ I + GG Sbjct: 302 RVYDAFADKLAAAVSKLKVGRGTESGATLGPLINEAAVKKVESHIADALAKGASLMTGGK 361 Query: 309 WDQSSR-YIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVF 367 + PT+L V P V +EE FGP+ P+ S EE ++ N E LA Y++ Sbjct: 362 RHALGHGFFEPTVLTGVKPDMDVAKEETFGPLAPLFRFASEEELVRLANDTEFGLAAYLY 421 Query: 368 SNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRS 427 S + + ++ G V N ++ V PFGGV SG+G + + + Sbjct: 422 SRDIGRVWRVAEALEYGMVGINTGLISNEVA--PFGGVKQSGLGREGSHYGIDDYVVIKY 479 Query: 428 CLV 430 V Sbjct: 480 LCV 482 >5UR2-A nrPDB Length = 984 Score = 421 bits (1084), Expect = e-118, Method: Composition-based stats. Identities = 104/435 (23%), Positives = 183/435 (42%), Gaps = 19/435 (4%) Query: 14 AFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEELDT 73 A+ + K + R ++ L ++ + + ++GK W ++ ++ Sbjct: 545 AYKTWKNVPCEQRAALVDKLADIMTRDRFKLIATQVLEVGKP-WAEADGDIGEAIDFCRY 603 Query: 74 TIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGN 133 + + + + V +Y GV VI WN+P + + A AGN Sbjct: 604 YARHMRELQKPLRVGGLPGELSHYIYKSR---GVTAVIAPWNFPLAILAGMVTAAAVAGN 660 Query: 134 AVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKER--FDHIMYTGST 190 V++KP+E S +A L +I + Q + + G E E + I +TGS Sbjct: 661 TVVMKPAEQSTVVAWGLMKMIQEAGFPQGVINFLPGYGEEVGEYIVNHKYTTTIAFTGSK 720 Query: 191 AVGKIVMAAAA------KHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTC 244 AVG +M AA +H+ +E+GGK+ +D D DLD A + + F SGQ C Sbjct: 721 AVGLHIMNRAAVVQPGQQHVKRCIIEMGGKNAVIIDNDADLDEAVDGVIYSAFGFSGQKC 780 Query: 245 VAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAK-QSRDYGRIINDRHFQRVKGLIDNQ-- 301 A ++ + ++ V++L ++ K A+ G +++ + R+ G I Sbjct: 781 SAASRVIVLDEVYDRFVDRLVETAKSIEIHPAENPKAYMGPVVDKEAYDRILGTIAEAEK 840 Query: 302 --KVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQRE 359 K+ G+ + PTI DV + + Q EIFGPV+ ++ ++L++A+ N E Sbjct: 841 NHKLLFKGSVPGGGFFAPPTIFGDVPGDAKLAQAEIFGPVVAVIRAKNLDQALDIANSTE 900 Query: 360 KPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAY-HGKKS 418 L VFS + I ++ E G + N I V PFGG SG+G+ G Sbjct: 901 YALTGGVFSRSPANINRVKEELEVGNLYVNRGITGAMVDRHPFGGFKMSGIGSKTGGPDY 960 Query: 419 FETFSHRRSCLVKSL 433 + + +L Sbjct: 961 LKQYMEPACVTENTL 975 >4LIH-A nrPDB Length = 504 Score = 421 bits (1083), Expect = e-118, Method: Composition-based stats. Identities = 120/427 (28%), Positives = 191/427 (44%), Gaps = 18/427 (4%) Query: 17 SGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEELDTTIK 76 + + R L ++ E+L +S D GK + +V ++ Sbjct: 82 VWAGLNPRARKAVLLRWAALMREHLDELSLLETLDAGKPIGDTTTVDVPGAA----YCVE 137 Query: 77 ELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVI 136 + + + EP+GVV + WN+P + A+AAGN+V+ Sbjct: 138 WFAEAIDKVGGEVAPADHHLVGLVTREPVGVVAAVVPWNFPILMAAWKFGPALAAGNSVV 197 Query: 137 LKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKER-FDHIMYTGSTAVGK 194 LKPSE S A +A L + + ++ VV G L R D I +TGSTAVGK Sbjct: 198 LKPSEKSPLTAIRVAQLAFEAGIPAGVFNVVPGAGEPGKLLALHRDVDCIAFTGSTAVGK 257 Query: 195 IVMAAAAK-HLTPVTLELGGKSPCYVDKDC-DLDVACRRIAWGKFMNSGQTCVAPDYILC 252 ++M AA+ +L LELGGKSP V DC DLD A + A F N G+ C A +L Sbjct: 258 LIMQYAAQSNLKRAWLELGGKSPNIVLPDCPDLDRAAQTAAGAIFYNMGEMCTAGSRLLV 317 Query: 253 DPSIQNQIVEKLKKSLKDFY-GEDAKQSRDYGRIINDRHFQRVKGLID----NQKVAHGG 307 I++ +EKL + + + G S G I++ +RV G I+ ++ GG Sbjct: 318 HRDIKDAFIEKLVAAARAYVPGNPLDPSVSMGAIVDGIQLERVLGYIEAGRGEGRLVTGG 377 Query: 308 TW---DQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLAL 364 + Y+ PT+ +V P + + +EEIFGPV+ ++ ++EA++ N E LA Sbjct: 378 ARVNAETGGFYVEPTVF-EVKPDAKIAREEIFGPVLSVIVFDDVDEAVRIANDTEYGLAA 436 Query: 365 YVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSH 424 V+++N + +G V N + PFGG SG G + E ++ Sbjct: 437 AVWTSNLTTAHDVSRRLRAGTVWVNCYDEGGDM-NFPFGGYKQSGNGRDKSLHALEKYTE 495 Query: 425 RRSCLVK 431 +S L++ Sbjct: 496 LKSTLIR 502 >2HG2-A nrPDB Length = 479 Score = 418 bits (1075), Expect = e-117, Method: Composition-based stats. Identities = 117/442 (26%), Positives = 196/442 (44%), Gaps = 17/442 (3%) Query: 2 SSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 + A A + R L + I E IS + + GK + + Sbjct: 44 EDARKAIDAAERAQPEWEALPAIERASWLRKISAGIRERASEISALIVEEGGKIQQLAEV 103 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLT 121 EVA + +D + + E E + R + + + LGV I WN+PF L Sbjct: 104 -EVAFTADYIDYMAEWARRY-EGEIIQSDRPGEN--ILLFKRALGVTTGILPWNFPFFLI 159 Query: 122 IQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQ-YMDQNLYLVVKGGVPETTELL--K 178 + M A+ GN +++KPSE + + A A ++ + + + ++ +V G + L Sbjct: 160 ARKMAPALLTGNTIVIKPSEFTPNNAIAFAKIVDEIGLPRGVFNLVLGRGETVGQELAGN 219 Query: 179 ERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFM 238 + + TGS + G+ +MA AAK++T V LELGGK+P V D DL++A + I + + Sbjct: 220 PKVAMVSMTGSVSAGEKIMATAAKNITKVCLELGGKAPAIVMDDADLELAVKAIVDSRVI 279 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAK-QSRDYGRIINDRHFQRV-- 294 NSGQ C + + I +Q V +L ++++ +G A+ G +IN +RV Sbjct: 280 NSGQVCNCAERVYVQKGIYDQFVNRLGEAMQAVQFGNPAERNDIAMGPLINAAALERVEQ 339 Query: 295 ---KGLIDNQKVAHGGT-WDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEE 350 + + + +VA GG + Y PT+L+DV + +M EE FGPV+P+V +LE+ Sbjct: 340 KVARAVEEGARVAFGGKAVEGKGYYYPPTLLLDVRQEMSIMHEETFGPVLPVVAFDTLED 399 Query: 351 AIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGM 410 AI N + L +++ N V K I G N G SG+ Sbjct: 400 AISMANDSDYGLTSSIYTQNLNVAMKAIKGLKFGETYINRENFEAMQGFHA--GWRKSGI 457 Query: 411 GAYHGKKSFETFSHRRSCLVKS 432 G GK + + ++S Sbjct: 458 GGADGKHGLHEYLQTQVVYLQS 479 >2JG7-A nrPDB Length = 510 Score = 415 bits (1068), Expect = e-116, Method: Composition-based stats. Identities = 95/446 (21%), Positives = 191/446 (42%), Gaps = 20/446 (4%) Query: 1 MSSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 ++ +TV++ REA+ R + + + + + +K + ++ ++GK Y Sbjct: 56 LAEYEETVQKTREAWKMWADIPAPKRGEIVRQIGDALRKKIKVLGSLVSLEMGK----IY 111 Query: 61 YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNL 120 E V V E +D + + L P+G+V +I A+N+P + Sbjct: 112 VEGVGEVQEYVDVCDYAVGLSRMIGGPVLPSERPGHALIEQWNPVGLVGIITAFNFPVAV 171 Query: 121 TIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQN-----LYLVVKGGVPETTE 175 A+ GN + K + + + + ++ + ++QN + + GG T Sbjct: 172 YGWNNAIALTCGNVCLWKGAPTTPLTSVAVTKIVAEVLEQNNLPGAICSMTCGGADIGTA 231 Query: 176 LL-KERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAW 234 + ER D + +TGST VGK+V + LELGG + V +D DL++ + Sbjct: 232 MAKDERVDLLSFTGSTHVGKMVAMMVQERFGRKLLELGGNNAIIVFEDADLNLVVPSAVF 291 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQR 293 +GQ C ++ S+ + +VE++ K+ K G+ S YG + + + Sbjct: 292 ASVGTAGQRCTTTRRLMLHESVHDAVVERIAKAYKQVRIGDPWDPSTLYGPLHTKQAVDQ 351 Query: 294 VKGLIDNQK------VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRS 347 I+ K V G D+ Y+ PTI+ + +P++ E F P++ ++ ++ Sbjct: 352 YLAAIEQAKQQGGTLVCGGKVMDRPGNYVEPTIITGLAHDAPIVHTETFVPILYVLKFKT 411 Query: 348 LEEAIQFINQREKPLALYVFSNNEKVIKKMI--AETSSGGVTANDVIVHITVPTLPFGGV 405 EEA + N+ ++ L+ +F+ + + + + + G V N + FGG Sbjct: 412 EEEAFAWNNEVQQGLSSSIFTKDLGRVFRWLGPKGSDCGIVNVNIPTSGAEIGG-AFGGE 470 Query: 406 GNSGMGAYHGKKSFETFSHRRSCLVK 431 ++G G G S++ + R +C + Sbjct: 471 KHTGGGRESGSDSWKQYMRRSTCTIN 496 >5UCD-A nrPDB Length = 457 Score = 414 bits (1065), Expect = e-116, Method: Composition-based stats. Identities = 163/431 (37%), Positives = 249/431 (57%), Gaps = 8/431 (1%) Query: 6 DTVKRAREA-FNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEV 64 D++ A++A F + T + FR Q LE L+ + N +++ ALA DLGK + E+ Sbjct: 31 DSLFSAQKAYFATRATADVGFRKQSLERLKEAVINNKEALYSALAEDLGKPKDVVDLAEI 90 Query: 65 AHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQP 124 VL E+D + L +W V + Y+ EP GV +IG +NYP NLT+ P Sbjct: 91 GAVLHEIDFALAHLDEWVAPVSVPSPDIIAPSECYVVQEPYGVTYIIGPFNYPVNLTLTP 150 Query: 125 MVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLKERFDHI 184 ++GA+ GN I+KPSE + + ++ +I + V++GG E + LL FD I Sbjct: 151 LIGAIIGGNTCIIKPSETTPETSAVIEKIIAEAFAPEYVAVIQGGRDENSHLLSLPFDFI 210 Query: 185 MYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTC 244 +TGS VGK+VM AAAKHLTPV LELGGK P V D DLD ++ +GKF+NSGQT Sbjct: 211 FFTGSPNVGKVVMQAAAKHLTPVVLELGGKCPLIVLPDADLDQTVNQLMFGKFINSGQTX 270 Query: 245 VAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLID--NQK 302 +APDY+ S+++ ++E+L + +K + + G+++ +R QR+ L++ + Sbjct: 271 IAPDYLYVHYSVKDALLERLVERVKT----ELPEINSTGKLVTERQVQRLVSLLEATQGQ 326 Query: 303 VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQ-REKP 361 V G D S R ++ T++ V+ P+M EE+FGP++P++ S+ AI +N+ KP Sbjct: 327 VLVGSQADVSKRALSATVVDGVEWNDPLMSEELFGPILPVLEFDSVRTAIDQVNKHHPKP 386 Query: 362 LALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFET 421 LA+YVF + V K +I + SG N V++H P LPFGG+G SGMG YHG S+ T Sbjct: 387 LAVYVFGKDMDVAKGIINQIQSGDAQVNGVMLHAFSPYLPFGGIGASGMGEYHGHFSYLT 446 Query: 422 FSHRRSCLVKS 432 F+H++S + Sbjct: 447 FTHKKSVRIVP 457 >3RHD-A nrPDB Length = 486 Score = 413 bits (1063), Expect = e-116, Method: Composition-based stats. Identities = 114/447 (25%), Positives = 199/447 (44%), Gaps = 26/447 (5%) Query: 2 SSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 + + A + K + R L + + I E + ++ LA D GK + Sbjct: 34 EEAKEAIDTAEKYKEVMKNLPITKRYNILMNIAKQIKEKKEELAKILAIDAGKPIKQARV 93 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLT 121 EV + + + + + + ++ EP+G+V I +N+P NL+ Sbjct: 94 -EVERSIGTFKLAAFYVKEHRD-----EVIPSDDRLIFTRREPVGIVGAITPFNFPLNLS 147 Query: 122 IQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYM-----DQNLYLVVKGGVPETTE- 175 + A+A GN ++ PS + + LA +I + +Y ++ G + Sbjct: 148 AHKIAPAIATGNVIVHHPSSKAPLVCIELAKIIENALKKYNVPLGVYNLLTGAGEVVGDE 207 Query: 176 -LLKERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAW 234 ++ E+ + I +TGS+ VG+++ A + LELGG +P V KD DL+ A + Sbjct: 208 IVVNEKVNMISFTGSSKVGELITKKAG--FKKIALELGGVNPNIVLKDADLNKAVNALIK 265 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQR 293 G F+ +GQ C++ IL D SI ++ +E K G + D G +I+ H + Sbjct: 266 GSFIYAGQVCISVGMILVDESIADKFIEMFVNKAKVLNVGNPLDEKTDVGPLISVEHAEW 325 Query: 294 VKGLI-----DNQKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSL 348 V+ ++ + K+ GG D++ Y PTIL +VD + + + E F PV+PI+ + Sbjct: 326 VEKVVEKAIDEGGKLLLGGKRDKALFY--PTIL-EVDRDNILCKTETFAPVIPIIR-TNE 381 Query: 349 EEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNS 408 EE I N E L +F+N+ K GGV ND + +PFGGV S Sbjct: 382 EEMIDIANSTEYGLHSAIFTNDINKSLKFAENLEFGGVVINDSSL-FRQDNMPFGGVKKS 440 Query: 409 GMGAYHGKKSFETFSHRRSCLVKSLLN 435 G+G K + E S+ ++ ++ N Sbjct: 441 GLGREGVKYAMEEMSNIKTIIISKAEN 467 >3K2W-A nrPDB Length = 497 Score = 413 bits (1062), Expect = e-116, Method: Composition-based stats. Identities = 116/426 (27%), Positives = 182/426 (42%), Gaps = 20/426 (4%) Query: 22 SLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEELDTTIKELPDW 81 + + R L I EN ++ L ++ GK + EV +D Sbjct: 70 TARTRQNMLRTFANKIRENKHILAPMLVAEQGKLLSVAEM-EVDVTATFIDYGCDNALTI 128 Query: 82 AEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSE 141 D Q + +YIH P GVV+ I AWN+P L + + A+ GN ++LKP++ Sbjct: 129 EGD---ILPSDNQDEKIYIHKVPRGVVVGITAWNFPLALAGRKIGPALITGNTMVLKPTQ 185 Query: 142 VSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKERF--DHIMYTGSTAVGKIVMA 198 + L + + + + V+ G + L E I TGST GK + Sbjct: 186 ETPLATTELGRIAKEAGLPDGVLNVINGTGSVVGQTLCESPITKMITMTGSTVAGKQIYK 245 Query: 199 AAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQN 258 +A+++TPV LELGGK+P V D DLD A WG+F N GQ C + + S+ + Sbjct: 246 TSAEYMTPVMLELGGKAPMVVMDDADLDKAAEDALWGRFANCGQVCTCVERLYVHASVYD 305 Query: 259 QIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGLI-----DNQKVAHGGTWD-- 310 + + K +K G+ G N R + ++ VA GG Sbjct: 306 EFMAKFLPLVKGLKVGDPMDADSQMGPKCNQREIDNIDHIVHEAIKQGATVATGGKTATV 365 Query: 311 ---QSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVF 367 + + PT+LVDV + V+ EE FGP++PIV V S+E+AI+F N L+ YV Sbjct: 366 EGFEGGCWYEPTVLVDVKQDNIVVHEETFGPILPIVKVSSMEQAIEFCNDSIYGLSAYVH 425 Query: 368 SNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRS 427 + + I + I++ G V N + G SG G GK E + +++ Sbjct: 426 TQSFANINQAISDLEVGEVYINRGMGEQHQGFH--NGWKQSGFGGEDGKFGLEQYLEKKT 483 Query: 428 CLVKSL 433 + Sbjct: 484 VYINEA 489 >3VZ3-A nrPDB Length = 457 Score = 413 bits (1062), Expect = e-116, Method: Composition-based stats. Identities = 106/439 (24%), Positives = 193/439 (43%), Gaps = 16/439 (3%) Query: 2 SSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 + I + +A+EAF + + S R Q LE ++ + + + +++GK ++ Sbjct: 26 AEIDAKLAKAQEAFQAYRRTSFSQRRQWLENAAAILERDTSKFAEIMTTEMGKTHQSAIA 85 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLT 121 E E+ + + E + +TQ + Y+ +PLG++L + WN+PF Sbjct: 86 E-----AEKSALVCRYYAEHGEQFLANEYTETQATESYVCYQPLGILLAVMPWNFPFWQV 140 Query: 122 IQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELL-KE 179 + A+ AGN +LK + A + ++ + ++ + G + +++ Sbjct: 141 FRFAAPALMAGNVAVLKHASNVPQCALAVEAILEAAGFPEGVFQTLLIGASQVEQVIKDP 200 Query: 180 RFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMN 239 R TGS G + + A + + P LELGG P V DLD A + MN Sbjct: 201 RVKAATLTGSEPAGASLASLAGQEIKPTLLELGGSDPFVVFPSADLDEAVEVGTVARTMN 260 Query: 240 SGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGLI 298 +GQ+ +A + +I + +EKL G+ D G + + Q + + Sbjct: 261 NGQSAIAAKRFILHEAIAAEFLEKLHLKFASLKIGDPMAPETDIGPLATEGILQDISRQV 320 Query: 299 D-----NQKVAHGGT-WDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAI 352 D K+ GG D++ + PTIL ++ P + ++QEE+F PV + V+ L++AI Sbjct: 321 DQAVAAGAKILLGGRPLDRAGYFYPPTILTEIPPGAKILQEELFAPVAMVFTVKDLDQAI 380 Query: 353 QFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGA 412 N L ++N+ ++ I E +G V N ++ + P LPFGG SG G Sbjct: 381 ALANDIPFGLGASAWTNDPAEQQRFIQELDAGAVFINGMV--KSDPRLPFGGTKRSGYGR 438 Query: 413 YHGKKSFETFSHRRSCLVK 431 G TF + ++ +K Sbjct: 439 ELGLAGIRTFVNAKTVWLK 457 >5EUY-A nrPDB Length = 491 Score = 412 bits (1059), Expect = e-115, Method: Composition-based stats. Identities = 112/440 (25%), Positives = 197/440 (44%), Gaps = 17/440 (3%) Query: 2 SSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 + + A EA + R + L + + + + L + G + Sbjct: 46 EDAREAIDSAFEALKAWANIPAIRRAEYLYKMLEVFRQMKEDFMKILTVEGGGTYRKVWG 105 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVA-KTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNL 120 E V + I+ + A ++ + GVV VI WNYP ++ Sbjct: 106 EVV-----FTERLIQNAAELARHYQGRVLQSDSESTISVVFKRSKGVVGVITPWNYPLSI 160 Query: 121 TIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTE--LL 177 +++ + +A GN V+ KP+ + L+A ++ + + + ++ +V G P E + Sbjct: 161 SMKKIAHTLAVGNTVVYKPASDTPVTGWLIAQMVAKAGLPKGVFNLVIGPGPVVGEEIVT 220 Query: 178 KERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKF 237 +R H+ +TG ++ G+ + A AA L VTLELGG P + D D+D A R + Sbjct: 221 HKRVAHVTFTGESSTGREIAAKAAGTLKTVTLELGGSDPLIILDDVDVDYAARLAVFASL 280 Query: 238 MNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDA--KQSRDYGRIINDRHFQRVK 295 + GQ C + I+ ++ ++ +E+ +K +D + D G +IN+R +K Sbjct: 281 FHQGQICTSAKRIIVHKAVADKFIERYVHYVKMLRIDDPRKDEKVDLGPLINERQVALMK 340 Query: 296 GLIDNQKVAHGGTWDQSSR----YIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEA 351 +D+ V+ GG R + P I VDVD +M+EE+FGPV PIV V + ++A Sbjct: 341 EFVDDA-VSRGGRLLIGGRSWGNFFEPAIFVDVDRNFRIMREEVFGPVRPIVVVENDDQA 399 Query: 352 IQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMG 411 ++ N + L+ V +NN ++ SG NDV + +PFGG+ SG+G Sbjct: 400 VEVANDTDYGLSGAVLTNNVNRAFRIAEAVESGMFHINDVTF-LEESHVPFGGIKASGVG 458 Query: 412 AYHGKKSFETFSHRRSCLVK 431 G+ SF ++ R V Sbjct: 459 REGGEWSFHETTYDRWVTVT 478 >1T90-A nrPDB Length = 486 Score = 410 bits (1053), Expect = e-115, Method: Composition-based stats. Identities = 99/442 (22%), Positives = 194/442 (43%), Gaps = 17/442 (3%) Query: 2 SSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 I + A EAF + ++ R + L Q++++++ + ++ + + GKN + Sbjct: 43 EDIDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEAL- 101 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLT 121 EV +E ++ P + +A + Y P+GVV I +N+P + Sbjct: 102 GEVGRGIENVEFAAGA-PSLMMGDSLASIATDVEAANY--RYPIGVVGGIAPFNFPMMVP 158 Query: 122 IQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKE- 179 A+A GN ILKPSE + + + L L + + + ++ VV G +L+ Sbjct: 159 CWMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEHP 218 Query: 180 RFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMN 239 I + GS VG+ V +++L V G K+ V D +L+ I F + Sbjct: 219 EIKAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAAFGS 278 Query: 240 SGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGLI 298 +G+ C+A + + I ++ + KL++ + D G G +I + + +R I Sbjct: 279 AGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKRTLSYI 338 Query: 299 -----DNQKVAHGGTWD--QSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEA 351 + ++ G + ++ PTI +V + + ++EIF PV+ ++ V++L+EA Sbjct: 339 EKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIRVKNLKEA 398 Query: 352 IQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMG 411 I+ N+ E +F++N I+ +G + N V + PF G +S G Sbjct: 399 IEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGINLG-VPAPMAFFPFSGWKSSFFG 457 Query: 412 AYH--GKKSFETFSHRRSCLVK 431 H GK S + ++ ++ + Sbjct: 458 TLHANGKDSVDFYTRKKVVTAR 479 >3EK1-A nrPDB Length = 504 Score = 409 bits (1052), Expect = e-114, Method: Composition-based stats. Identities = 110/438 (25%), Positives = 187/438 (42%), Gaps = 16/438 (3%) Query: 1 MSSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 +++I + + + +A + ++ + R L +I N I+ + S+ GK + Sbjct: 69 VATIKEAIDASAKALSGWAAKTAKERAGILRKWFDLIIANADDIALIMTSEQGKPLAEAR 128 Query: 61 YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNL 120 EV + ++ +E D L + +P+GV I WN+P + Sbjct: 129 -GEVLYAASFIEWFAEEAKRVYGDTI---PAPQNGQRLTVIRQPVGVTAAITPWNFPAAM 184 Query: 121 TIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKE 179 + A+AAG +I++P++++ A L L + + + +V G E L Sbjct: 185 ITRKAAPALAAGCTMIVRPADLTPLTALALGVLAEKAGIPAGVLQIVTGKAREIGAELTS 244 Query: 180 R--FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKF 237 + +TGST VG+++MA A + ++LELGG +P V D DLD A K+ Sbjct: 245 NDTVRKLSFTGSTEVGRLLMAQCAPTIKRISLELGGNAPFIVFDDADLDAAVDGAMVSKY 304 Query: 238 MNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKG 296 N+GQTCV + I + ++ EKL +K+ G + G +I ++ +VK Sbjct: 305 RNAGQTCVCANRIYVQRGVYDKFAEKLAAKVKELKVGNGTEPGVVIGPMIEEKAITKVKA 364 Query: 297 LID-----NQKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEA 351 I+ K+ GG + + P IL V V +EE FGP+ P+ + EE Sbjct: 365 HIEDAVSKGAKLITGGK-ELGGLFFEPGILTGVTSDMLVAKEETFGPLAPLFAFDTEEEV 423 Query: 352 IQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMG 411 I N LA Y ++ N ++ G V N ++ V PFGGV SG+G Sbjct: 424 IAQANDTIFGLAAYFYTENFSRAIRVSEALEYGMVGHNTGLISNEVA--PFGGVKQSGLG 481 Query: 412 AYHGKKSFETFSHRRSCL 429 K E + + Sbjct: 482 REGSKYGIEEYLETKYIC 499 >3U4J-A nrPDB Length = 528 Score = 409 bits (1052), Expect = e-114, Method: Composition-based stats. Identities = 112/434 (25%), Positives = 196/434 (45%), Gaps = 18/434 (4%) Query: 18 GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEELDTTIKE 77 S R + + + +I + ++ + ++GK + E+ + + Sbjct: 79 WPRMSGAERSRLMFKVADLILARQEELALIESLEVGKPIAQAR-GEIGFCADLWSYAAGQ 137 Query: 78 LPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVIL 137 E + + + EP+GVV +I WN+PF + + + A+ +G V+L Sbjct: 138 -ARALEGQTHNNIGDDRLG--LVLREPVGVVGIITPWNFPFIIASERVPWAIGSGCTVVL 194 Query: 138 KPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKER--FDHIMYTGSTAVGK 194 KPSE + + LA L + + ++ VV G ++L E D + +TGS VG Sbjct: 195 KPSEFTSGTSIRLAELAREAGIPDGVFNVVTGYGDPAGQVLAEDPNVDMVAFTGSVRVGT 254 Query: 195 IVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDP 254 + AA+ + V LELGGK P V D DLD A IA+G + N+GQ C++ +L Sbjct: 255 KLGEIAARTVKRVGLELGGKGPQIVFADADLDAAADGIAYGVYHNAGQCCISGSRLLVQE 314 Query: 255 SIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGLI-----DNQKVAHGGT 308 I++ ++E+L + +G+ + G +I++ H ++V + ++ GG Sbjct: 315 GIRDALMERLLDISRKVAFGDPLNERTKIGAMISEAHAEKVHSYVTAGITSGAELLLGGE 374 Query: 309 WD--QSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYV 366 ++ Y APT+ V P + +EEIFGPV+ + ++ +EA+ N E L+ V Sbjct: 375 RIGREAGLYYAPTVFAGVTPDMSIAREEIFGPVLSTLTFKTADEAVALANATEFGLSASV 434 Query: 367 FSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRR 426 +S N + + I +G N VI P LP GG SG+G G+ F+ +S + Sbjct: 435 WSTNLETALQTIRRIRAGRCWINSVIDGT--PELPIGGYKKSGLGRELGRYGFDEYSQFK 492 Query: 427 SCLVKSLLNEEAHK 440 V +L Sbjct: 493 GVHV-TLGRPAPWF 505 >4U3W-A nrPDB Length = 505 Score = 409 bits (1051), Expect = e-114, Method: Composition-based stats. Identities = 104/445 (23%), Positives = 177/445 (39%), Gaps = 19/445 (4%) Query: 4 ISDTVKRAREAFNS-GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE 62 + V+ A A + + + R L + I A +D G+ + Sbjct: 61 VDSAVQAAHAAQKAGWRDTTPAQRAAWLHKIADGIEARFDEFVAAEVADTGRPVAQARTL 120 Query: 63 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTI 122 ++A + T + + + + Y+ +PLGV+ +I WN P L Sbjct: 121 DIARGIANFRTFADLVRTASGEYFETHAADGSELINYVTRKPLGVIGIISPWNLPLLLFT 180 Query: 123 QPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQ-YMDQNLYLVVKG-GVPETTELLKER 180 + A+A GN V+ KPSE + A LLA ++ + ++ ++ G G E L Sbjct: 181 WKVAPALAMGNCVVAKPSEETPSSATLLAEVMHDVGLPPGVFNLIHGHGQNAAGEFLTRH 240 Query: 181 FD--HIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFM 238 D I +TG + G +M A A + V+ ELGGK+ V D D D A + F Sbjct: 241 PDISAITFTGESRTGSTIMKAVADGVKEVSFELGGKNAAVVFADADFDAAVAGVLRSSFT 300 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGL 297 N+GQ C+ + + + I + V LK+ + G + G +I+ H +V Sbjct: 301 NAGQVCLCSERVYVERPIFERFVAALKEQAQALRVGAPEDPATTMGPLISRGHRDKVLSY 360 Query: 298 I-----DNQKVAHGGTWD------QSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVR 346 + V GG ++ PTI + + ++EEIFGPV I Sbjct: 361 FRLAVEEGATVVTGGGAPSFGDARDDGAFVMPTIWTGLPDSARCVREEIFGPVCHIAPFD 420 Query: 347 SLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVG 406 E ++ +N LA +++ ++ + +G V N V PFGG Sbjct: 421 DEAEVVKRVNDSAYGLAASIWTTQLARGHRVAKQIETGIVWVNAWFVRDL--RTPFGGTK 478 Query: 407 NSGMGAYHGKKSFETFSHRRSCLVK 431 SG+G G+ S + +S + V+ Sbjct: 479 LSGLGREGGRHSLDFYSELTNVCVR 503 >3B4W-A nrPDB Length = 495 Score = 408 bits (1050), Expect = e-114, Method: Composition-based stats. Identities = 118/424 (27%), Positives = 193/424 (45%), Gaps = 18/424 (4%) Query: 18 GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEELDTTIKE 77 + R + A +M+ E + LA++ G+ + ++ Sbjct: 64 WPSTPPHERAAVIAAAVKMLAERKDLFTKLLAAETGQPPTIIETMHWMGSMGAMN----Y 119 Query: 78 LPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVIL 137 A+ +TR + EP+GVV I AWN P L + + A+ AG ++L Sbjct: 120 FAGAADKVTWTETRTGSYGQSIVSREPVGVVGAIVAWNVPLFLAVNKIAPALLAGCTIVL 179 Query: 138 KPSEVSGHMADLLATLIPQ-YMDQNLYLVVKGGVPETTELL-KERFDHIMYTGSTAVGKI 195 KP+ + A+ LA + + + + + VV GG+ L D +TGS+AVG+ Sbjct: 180 KPAAETPLTANALAEVFAEVGLPEGVLSVVPGGIETGQALTSNPDIDMFTFTGSSAVGRE 239 Query: 196 VMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPS 255 V AA+ L P TLELGGKS + +D DL A + + MN+GQ CV IL S Sbjct: 240 VGRRAAEMLKPCTLELGGKSAAIILEDVDLAAAIPMMVFSGVMNAGQGCVNQTRILAPRS 299 Query: 256 IQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGLI-----DNQKVAHGGTW 309 ++IV + + G + + G +I+++ RV+G I + ++ GG Sbjct: 300 RYDEIVAAVTNFVTALPVGPPSDPAAQIGPLISEKQRTRVEGYIAKGIEEGARLVCGGGR 359 Query: 310 DQS---SRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYV 366 + +I PT+ DVD + + QEEIFGPV+ I+ + E+AI N LA V Sbjct: 360 PEGLDNGFFIQPTVFADVDNKMTIAQEEIFGPVLAIIPYDTEEDAIAIANDSVYGLAGSV 419 Query: 367 FSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRR 426 ++ + K+ + +G N + P PFGG NSG+G +G + E F+ ++ Sbjct: 420 WTTDVPKGIKISQQIRTGTYGIN---WYAFDPGSPFGGYKNSGIGRENGPEGVEHFTQQK 476 Query: 427 SCLV 430 S L+ Sbjct: 477 SVLL 480 >6MVR-A nrPDB Length = 767 Score = 406 bits (1043), Expect = e-113, Method: Composition-based stats. Identities = 106/416 (25%), Positives = 174/416 (41%), Gaps = 20/416 (4%) Query: 12 REAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEEL 71 R+A + R + L AL R++ ++ + + D GK + +V Sbjct: 78 RKAQPAWAK-DGAARARVLYALARLLQKHARLFAVLETLDNGKPIREARDIDVPLAQRHF 136 Query: 72 DTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAA 131 + P PLGV + WN+P + + A+A Sbjct: 137 YHHAGYAQLMGTEMP--------------DRAPLGVCGQVIPWNFPLLMLAWKIAPALAM 182 Query: 132 GNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKERFDHIMYTGST 190 GN V+LKP+E + A L A + Q + + +V G ++ + D + +TGST Sbjct: 183 GNTVVLKPAEWTPLTALLFADICGQAGVPAGVVNIVTGDGAVGEMIVTAQVDKVAFTGST 242 Query: 191 AVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYI 250 AVG+ + A A ++LELGGK P V D D+D A + + N GQ C A + Sbjct: 243 AVGRRIREATAGTGKALSLELGGKGPYVVCDDADIDSAVEGLVDAIWFNQGQVCCAGSRL 302 Query: 251 LCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGLIDNQK-VAHGGT 308 L I + KL+ + G+ + D G +++ RV+ ++ T Sbjct: 303 LVQEGIADVFHAKLRARMDSLRIGDPLDKCIDIGAMVHPDQLARVRDMVAANTDGEVYQT 362 Query: 309 WDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFS 368 + Y PT++ + P SP+MQ+EIFGPV+ R+ EA++ N LA V+S Sbjct: 363 AVPAGCYYPPTLISGLAPASPLMQQEIFGPVLVSTTFRTPAEAVEIANNTAYGLAASVWS 422 Query: 369 NNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSH 424 N + + + +G V N ++ PFGGV SG G G + ++ Sbjct: 423 ENVNLALDLAPKLVAGIVWING--TNMMDAAAPFGGVRESGFGREGGWEGLAGYTR 476 Score = 84.2 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 34/205 (16%), Positives = 68/205 (33%), Gaps = 10/205 (4%) Query: 3 SISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE 62 + + V+ A + + R Q L + ++ + + GK + Sbjct: 540 DLRNAVEAMNAA-SGWSRTTGHLRAQILYFIGENLSARADEFANRIKDMTGK-------D 591 Query: 63 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTI 122 A V +D WA+ + EP+G + ++ P + Sbjct: 592 GKAEVAASIDRLFSAAA-WADKYDGQVKGVPLRGVALAMKEPVGKIGILCPDAAPLLGLV 650 Query: 123 QPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKERF 181 M A+A GN V L SE A ++ + + ++ G + E + Sbjct: 651 SLMAPAIAMGNRVTLAASEAFPLAATDFYQVLDTSDVPAGVVNILTGAHADLAEPMARHL 710 Query: 182 DHIMYTGSTAVGKIVMAAAAKHLTP 206 D G + +++ AA+A +L Sbjct: 711 DLDAVWGLSGHAQVIEAASAGNLKR 735 >4X0T-A nrPDB Length = 513 Score = 405 bits (1041), Expect = e-113, Method: Composition-based stats. Identities = 93/446 (20%), Positives = 184/446 (41%), Gaps = 20/446 (4%) Query: 1 MSSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 ++ +TVK+AREA+ R + + + + E ++ + ++ ++GK Sbjct: 59 VADYEETVKKAREAWKIWADIPAPKRGEIVRQIGDALREKIQVLGSLVSLEMGK----IL 114 Query: 61 YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNL 120 E V V E +D + + L P+G+V +I A+N+P + Sbjct: 115 VEGVGEVQEYVDICDYAVGLSRMIGGPILPSERSGHALIEQWNPVGLVGIITAFNFPVAV 174 Query: 121 TIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQN-----LYLVVKGGVPETTE 175 A+ GN + K + + ++ + +I + ++ N + + GG T Sbjct: 175 YGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTA 234 Query: 176 LL-KERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAW 234 + ER + + +TGST VGK V + LELGG + +D DL + + Sbjct: 235 MAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALF 294 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQR 293 +GQ C + SI +++V +LKK+ G + YG + + Sbjct: 295 AAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSM 354 Query: 294 VKGLIDNQK-----VAHGGT-WDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRS 347 G ++ K V +GG D+ Y+ PTI+ + + + E F P++ + ++ Sbjct: 355 FLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKN 414 Query: 348 LEEAIQFINQREKPLALYVFSNNEKVIKKMI--AETSSGGVTANDVIVHITVPTLPFGGV 405 EE + N+ ++ L+ +F+ + I + + + G V N + FGG Sbjct: 415 EEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGG-AFGGE 473 Query: 406 GNSGMGAYHGKKSFETFSHRRSCLVK 431 ++G G G +++ + R +C + Sbjct: 474 KHTGGGRESGSDAWKQYMRRSTCTIN 499 >5J77-A nrPDB Length = 508 Score = 405 bits (1040), Expect = e-113, Method: Composition-based stats. Identities = 100/444 (22%), Positives = 192/444 (43%), Gaps = 23/444 (5%) Query: 2 SSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 + + A +AF + R + + + +I +N + + + GK + Sbjct: 40 DDVDRAIDAAEDAFWAWNDLGSVERSKIIYRAKELIEKNRAELENIIMEENGKPVKEA-K 98 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQ-QDDLYIHSEPLGVVLVIGAWNYPFNL 120 EEV V++++ + +WA T ++ + P G+V+ + WN+P + Sbjct: 99 EEVDGVIDQI----QYYAEWARKLNGEVVEGTSSHRKIFQYKVPYGIVVALTPWNFPAGM 154 Query: 121 TIQPMVGAVAAGNAVILKPSEVSGHMA-DLLATLIPQYMDQNLYLVVKGGVPETTELLKE 179 + + A+ GN V+LKPS + A ++ + + + + + G E + + E Sbjct: 155 VARKLAPALLTGNTVVLKPSSDTPGSAEWIVRKFVEAGVPKGVLNFITGRGSEIGDYIVE 214 Query: 180 R--FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKF 237 + I TGSTA G+ +M A+ ++ + LELGGK+P V KD D+D A + + W K+ Sbjct: 215 HKKVNLITMTGSTATGQRIMQKASANMAKLILELGGKAPFMVWKDADMDNALKTLLWAKY 274 Query: 238 MNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGL 297 N+GQ+C+A + + I + + + + + D K + D G +IN Q + Sbjct: 275 WNAGQSCIAAERLYVHEDIYDTFMSRFVELSRKLALGDPK-NADMGPLINKGALQATSEI 333 Query: 298 ID-----NQKVAHGGTWD------QSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVR 346 ++ K+ GG+ ++ + PTI+ + D +S + QEEIF PV+ + Sbjct: 334 VEEAKESGAKILFGGSQPSLSGPYRNGYFFLPTIIGNADQKSKIFQEEIFAPVIGARKIS 393 Query: 347 SLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVG 406 S+EE N + LA Y+F+ + +I + G + N + G Sbjct: 394 SVEEMYDLANDNKYGLASYLFTKDPNIIFEASERIRFGELYVNMPGPEASQGYHT--GFR 451 Query: 407 NSGMGAYHGKKSFETFSHRRSCLV 430 +G K + ++ V Sbjct: 452 MTGQAGEGSKYGISEYLKLKNIYV 475 >6FK3-A nrPDB Length = 536 Score = 405 bits (1040), Expect = e-113, Method: Composition-based stats. Identities = 116/448 (25%), Positives = 189/448 (42%), Gaps = 34/448 (7%) Query: 4 ISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEE 63 + +AREAF R Q L L +++ +++ + ++GK + Sbjct: 58 VRKAALKAREAFAEWSRTPAPIRGQVLFNLVKILEREKPTLTRLMVREVGKTPKEAA--- 114 Query: 64 VAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQ 123 V E +DT + + + + +L+ PLGVV +I A N+P + Sbjct: 115 -GDVQEAIDTALFFASEGRRLYGQTVPSEMRDKELFTFRRPLGVVGIITAGNFPIAVPSW 173 Query: 124 PMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPE-TTELLKERF 181 ++ AV GN V+ KPSE + ++ + A L + + + VV GG T + + E Sbjct: 174 KLIPAVLTGNTVVWKPSEDAPTLSFVFAKLFEEAGLPPGVLNVVFGGGKGSTGQWMVELM 233 Query: 182 D-----HIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGK 236 D +TGST VG+ + A ++L TLELGGK+P V +D DLD+A W Sbjct: 234 DEGLFQKFAFTGSTQVGRWIGEVAGRNLIRPTLELGGKNPLVVMRDADLDLAVEGAWWSA 293 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKD-FYGEDAK-QSRDYGRIINDRHFQRV 294 F GQ C + IL D I + + + ++ G YG IN+R F R Sbjct: 294 FATGGQRCTSAGNILVDAPIYEEFKRRFLERVEATLVGNPLLHPEVTYGPFINERFFARW 353 Query: 295 KGL-----IDNQKVAHGGTW-------------DQSSRYIAPTILVDVDPQSPVMQEEIF 336 + + ++ G ++ Y PT+ +V P + + EE+F Sbjct: 354 QEHYRVGEAEGARLLFGRGRITRENPYPRFLGDPEAGLYGWPTVW-EVRPGTRLFTEEVF 412 Query: 337 GPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHIT 396 GP + +V V +EEAI N L+ +++N+ +G + N+ V Sbjct: 413 GPTINLVKVDGIEEAIAVANSTPYGLSSAIYTNHRHWAYLFKVGIRAGMTSINNATVGAE 472 Query: 397 VPTLPFGGVGNSGM-GAYHGKKSFETFS 423 LPFGGV SG G G E ++ Sbjct: 473 -AHLPFGGVKASGNGGRESGIWVLEEYT 499 >4JZ6-A nrPDB Length = 500 Score = 404 bits (1039), Expect = e-113, Method: Composition-based stats. Identities = 105/459 (22%), Positives = 182/459 (39%), Gaps = 30/459 (6%) Query: 1 MSSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 ++ + A EAF + K R + L + ++ +A ++G + + Sbjct: 56 VTDAIKAAQAAEEAFKTWKDVGPSERRRLLLKVADVMESKTPKFIEVMAMEVGASALWA- 114 Query: 61 YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLY--IHSEPLGVVLVIGAWNYPF 118 + +E A +T T + + +P+G +L I WN Sbjct: 115 ----GFNVHASANVFREAASLATQ-IQGETIPTDKAETLSMTLRQPVGPILSIVPWNGTA 169 Query: 119 NLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVV---KGGVPETT 174 L + + + GN V+ K SE S L+ + + + + + PE Sbjct: 170 VLAARAIAYPLVCGNTVVFKGSEFSPATHALITQCVQEAGLPAGVLNYLNSSPDRSPEIA 229 Query: 175 ELL--KERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRI 232 + L + I +TGST VG I+ AA+HL LELGGKSP V D D++ A + Sbjct: 230 DALISAKEIRRINFTGSTRVGSIIAQKAAQHLKRCLLELGGKSPLIVLDDADINAAVKAA 289 Query: 233 AWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRD--YGRIINDRH 290 +G F+ GQ C++ + ++ D I ++ V + + + D + D G +++ Sbjct: 290 VFGSFLFQGQICMSTERLVVDEKIADEFVARFVEKTERLSVGDPCLTGDCIIGPMVSPNS 349 Query: 291 FQRVKGLI-----DNQKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCV 345 +R+ GL KV GG + TIL V + EE FGP+ ++ Sbjct: 350 GERINGLFKDAIDKGAKVVCGGMA--QGAVMPATILDHVKSDMRIYDEETFGPITVVIRC 407 Query: 346 RSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGV 405 + EAI+ N L+ VF + ++ G V N V P+GG Sbjct: 408 KGEAEAIRIANDSVYGLSSGVFGRDINRALRVGMSIEYGCVHINGSTVQ-NEAQAPYGGT 466 Query: 406 GNSGMGAYHGKKSFETFSHRRSCLVKSLLNEEAHKARYP 444 N+G G + G+ + F+ + L E + +YP Sbjct: 467 KNTGYGRFDGRAVIDEFTELK------WLTIEPFEQQYP 499 >4ZZ7-A nrPDB Length = 501 Score = 403 bits (1037), Expect = e-113, Method: Composition-based stats. Identities = 90/443 (20%), Positives = 183/443 (41%), Gaps = 21/443 (4%) Query: 3 SISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE 62 ++ + A+ AF + + R + + + ++ ++ I + + GK Sbjct: 44 TVEQAISAAQHAFPTWRNTPPLKRARVMFRFKELLEQHADEICRLIGEEHGK-IAHDAMG 102 Query: 63 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTI 122 E+ +E ++ P+ + E D + +P+GVV I +N+P + + Sbjct: 103 ELQRGIENVEYACGA-PELLKGEHSRNVGP--GIDSWSEFQPMGVVAGITPFNFPVMVPL 159 Query: 123 QPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELL-KER 180 A+ GN +LKPSE +A L+ + + + VV G LL +R Sbjct: 160 WMFPMAIVCGNCFVLKPSERDPSSTLYIAQLLQEAGLPDGVMNVVNGDKEAVDALLHDDR 219 Query: 181 FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNS 240 + + GST + + + A+ + G K+ V D D+D A ++ F +S Sbjct: 220 VKAVSFVGSTPIAEYIYRTASANGKRCQALGGAKNHAIVMPDADMDNAVNQLLGAAFGSS 279 Query: 241 GQTCVAPDYIL-CDPSIQNQIVEKLKKSLKDFYGED-AKQSRDYGRIINDRHFQRVKGLI 298 G+ C+A + + + +V K+ ++++ D+G +I +H ++V G I Sbjct: 280 GERCMALSVAVAVGDAAGDALVSKMTQAMQKLKVGPSTDSGNDFGPVITRQHQEKVIGYI 339 Query: 299 -----DNQKVAHGGTWD-----QSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSL 348 + G ++ ++ T++ V P+ QEEIFGPV+ +V V ++ Sbjct: 340 NSAEQQGATIVVDGRQPKVPNHENGFFVGGTLIDHVTPEMTSYQEEIFGPVLQVVRVATM 399 Query: 349 EEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNS 408 ++A+ I+ E +F+ + + + G V N + + + V FGG S Sbjct: 400 QDAMDLIDAHEYGNGTCIFTRDGEAARYFSDNIQVGMVGIN-IPLPVPVAYHSFGGWKRS 458 Query: 409 GMGAYH--GKKSFETFSHRRSCL 429 G H G + ++ R++ Sbjct: 459 LFGDLHAYGPDAVRFYTKRKTVT 481 >4DNG-A nrPDB Length = 485 Score = 400 bits (1029), Expect = e-112, Method: Composition-based stats. Identities = 109/445 (24%), Positives = 196/445 (44%), Gaps = 12/445 (2%) Query: 3 SISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE 62 + D A++A + + R L+ + ++EN I +A + G S Sbjct: 45 QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKSTI- 103 Query: 63 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTI 122 E+ + LD + + + V + + + +Y PLGV+ I +N+P NL++ Sbjct: 104 ELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIY--RLPLGVISSISPFNFPMNLSM 161 Query: 123 QPMVGAVAAGNAVILKPSEVSGHMA-DLLATLIP-QYMDQNLYLVVKGGVPETTE--LLK 178 + + A+A GN+V+ KP + ++A + + V+ V E + L Sbjct: 162 RSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGMLTN 221 Query: 179 ERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFM 238 I +TGSTAVG+ + A + + LELGG +P V D D+D A +GKF+ Sbjct: 222 PIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAIFGKFI 281 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGL 297 + GQ C+ + I+ + ++ VEK +K YG+ G +IN+R ++ + Sbjct: 282 HQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQIEKALEI 341 Query: 298 IDNQK---VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQF 354 I+ K + + + P + V D S + Q E+F P+ I+ S +EAI Sbjct: 342 IEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKAGSDQEAIDM 401 Query: 355 INQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYH 414 N E L+ VF+++ + +K + SG ND V+ + P + FGG SG+G + Sbjct: 402 ANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDS-PNIAFGGNKASGVGRFG 460 Query: 415 GKKSFETFSHRRSCLVKSLLNEEAH 439 E F+ + ++ + Sbjct: 461 NPWVVEEFTVTKWISIQKQYRKYPF 485 >3VZ0-A nrPDB Length = 459 Score = 400 bits (1027), Expect = e-112, Method: Composition-based stats. Identities = 115/442 (26%), Positives = 187/442 (42%), Gaps = 23/442 (5%) Query: 2 SSISDTVKRAREAFNS-GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 + + D RA + + K RS+ R + + ++ + + + +A+++GK Sbjct: 27 AQMKDITDRAEHVWKTDWKLRSIAQRKEIVSRAADLLRRDRQHHASLIATEMGK------ 80 Query: 61 YEEVAHVLEELDTTIK---ELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYP 117 + LEE+D T + AE+ + + I ++PLG++ I WN+P Sbjct: 81 --ALPDALEEIDVTADILSFYANGAEEFLAPTPLKVKTGQAKIINQPLGIIYCIEPWNFP 138 Query: 118 FNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTEL 176 + + + AGN VI K + A L Y + ++ EL Sbjct: 139 YYQLARVAGPNLMAGNVVIAKHAPNVPQCALAFEKLFHDAGAPVGAYANIFLDNDQSAEL 198 Query: 177 L-KERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWG 235 + ER + TGS G+ V A A L T+ELGG V D DLD+A + WG Sbjct: 199 IKDERIRGVALTGSERAGQAVAAQAGAALKKDTMELGGSDAFIVLDDADLDLAVKWAVWG 258 Query: 236 KFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDR----H 290 +F N+GQ C A ++ + + ++ LK ++ F G + +G + + R Sbjct: 259 RFANNGQVCTAAKRMIVHEKVYDAFLDGLKTAITRFRIGNPLDRDTTHGPMSSLRAMELA 318 Query: 291 FQRVKGLIDNQK--VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSL 348 + + VA G D+ ++ PTIL DV +PV +EIFGPV + V S Sbjct: 319 LDQTAEAVKGGATLVAGGKRMDRKGFFMEPTILTDVSKDNPVFYQEIFGPVAVVHKVASE 378 Query: 349 EEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNS 408 + AI N L VFS + +K+ + +G V N P LPFGG+ NS Sbjct: 379 QAAIDLANDSPYGLGGAVFSRDIARAEKVAEQVETGMVFINTAT--AAAPELPFGGIKNS 436 Query: 409 GMGAYHGKKSFETFSHRRSCLV 430 G G E F +R+ + Sbjct: 437 GFGRELSFLGIEEFINRKLVRI 458 >3PRL-A nrPDB Length = 505 Score = 399 bits (1026), Expect = e-111, Method: Composition-based stats. Identities = 118/443 (26%), Positives = 190/443 (42%), Gaps = 14/443 (3%) Query: 2 SSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 ++D ++ A++A K R + R+ L A ++ E + I + ++ K + S Sbjct: 49 EEVNDAIQGAKDAQKIWKIRPIHERVDLLYAWADLLEERKEIIGELIMHEVAKPK-KSAI 107 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAK--TRQTQQDDLYIHSEPLGVVLVIGAWNYPFN 119 EV+ + + T E + + + + EPLGVVL I +NYP N Sbjct: 108 GEVSRTADIIRHTADEALRLNGETLKGDQFKGGSSKKIALVEREPLGVVLAISPFNYPVN 167 Query: 120 LTIQPMVGAVAAGNAVILKPSEVSGHMADLLAT-LIPQYMDQNLYLVVKGGVPETTELLK 178 L + A+ GN V+ KP+ + L + + VV G + L Sbjct: 168 LAAAKIAPALVTGNTVVFKPATQGSLSGIKMVEALADAGAPEGIIQVVTGRGSVIGDHLV 227 Query: 179 ER--FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGK 236 E D I +TG T G+ + A + PV LELGGK P V D DL + +I G Sbjct: 228 EHPGIDMITFTGGTTTGERISEKAK--MIPVVLELGGKDPAIVLDDADLKLTASQIVSGA 285 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKG 296 F SGQ C A + S+ +Q+V +K+ ++ + D +I+++ ++G Sbjct: 286 FSYSGQRCTAIKRVFVQDSVADQLVANIKELVEQLTVGSPEDDADITPVIDEKSAAFIQG 345 Query: 297 LIDNQKVAHGGTW----DQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAI 352 LID+ + +G T + ++PT+L DV P V EE FGPV+PI+ V+ EAI Sbjct: 346 LIDDA-LENGATLLSGNKRQGNLLSPTLLDDVTPAMRVAWEEPFGPVLPIIRVKDANEAI 404 Query: 353 QFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGA 412 NQ + L +F+ + + G V N PF GV SG+G Sbjct: 405 SLSNQSDYGLQASIFTKDTDRAINIGKHLEVGTVHINAK-TERGPDHFPFLGVKKSGLGV 463 Query: 413 YHGKKSFETFSHRRSCLVKSLLN 435 K S + + R ++ N Sbjct: 464 QGIKPSLLSMTRERVTVLNLAEN 486 >5TJR-A nrPDB Length = 531 Score = 399 bits (1025), Expect = e-111, Method: Composition-based stats. Identities = 106/445 (23%), Positives = 183/445 (41%), Gaps = 23/445 (5%) Query: 2 SSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 ++ + A+ AF + + R Q L ++++ N + I ++ + GK + Sbjct: 73 ETMQQAIDAAKAAFPAWRNTPPAKRAQVLFRFKQLLEANEERIVKLISEEHGKTIEDAA- 131 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLT 121 E+ +E ++ P+ + E D + +P+GVV I +N+P + Sbjct: 132 GELKRGIENVEY-ATAAPEILKGEYSRNVGP--NIDAWSDFQPIGVVAGITPFNFPAMVP 188 Query: 122 IQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELL-KE 179 + A+A GN ILKPSE L+A L + + + + VV G L+ Sbjct: 189 LWMYPLAIACGNTFILKPSERDPSSTLLIAELFHEAGLPKGVLNVVHGDKGAVDALIEAP 248 Query: 180 RFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMN 239 + + GST + + + + K V G K+ + D DLD A + + + Sbjct: 249 EVKALSFVGSTPIAEYIYSEGTKRGKRVQALGGAKNHAVLMPDADLDNAVSALMGAAYGS 308 Query: 240 SGQTCVAPDYIL-CDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGL 297 G+ C+A + I + +V+KL +K G D G ++ +V G Sbjct: 309 CGERCMAISVAVCVGDQIADALVQKLVPQIKGLKIGAGTSCGLDMGPLVTGAARDKVTGY 368 Query: 298 IDNQKVAHGGTWD-----------QSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVR 346 ID VA G ++ ++ T+ V P+ + +EEIFGPV+ IV V Sbjct: 369 IDTG-VAQGAELVVDGRGYKVAGHENGFFLGGTLFDRVTPEMTIYKEEIFGPVLCIVRVN 427 Query: 347 SLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVG 406 SLEEA+Q IN E +F+ + + + E G V N V + + V FGG Sbjct: 428 SLEEAMQLINDHEYGNGTCIFTRDGEAARLFCDEIEVGMVGVN-VPLPVPVAYHSFGGWK 486 Query: 407 NSGMGAYH--GKKSFETFSHRRSCL 429 S G H G ++ R++ Sbjct: 487 RSLFGDLHAYGPDGVRFYTKRKAIT 511 >4OGD-A nrPDB Length = 465 Score = 397 bits (1020), Expect = e-111, Method: Composition-based stats. Identities = 96/444 (21%), Positives = 181/444 (40%), Gaps = 17/444 (3%) Query: 4 ISDTVKRAREAFNSGKTRS-LQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE 62 ++D ++RA + + L+ R QL + ++ + + + D+GK + Sbjct: 25 LADVLERAHLLYKKWRKEDHLEERKAQLHQVANILRRDRDKYAEIMTKDMGK-----LFT 79 Query: 63 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTI 122 E ++ D A++ ++ +T Y + GV+L + WN+P+ + Sbjct: 80 EAQGEVDLCADIADYYADKADEFLMSTPLETDSGQAYYLKQSTGVILAVEPWNFPYYQIM 139 Query: 123 QPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQN--LYLVVKGGVPETTELLKER 180 + GN ++LK + + A L+ + + + + + + +R Sbjct: 140 RVFAPNFIVGNPMVLKHASICPRSAQSFEELVLEAGAEAGSITNLFISYDQVSQVIADKR 199 Query: 181 FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNS 240 + TGS G + A K+L TLELGG + D D D + + + + N+ Sbjct: 200 VVGVCLTGSERGGASIAEEAGKNLKKTTLELGGDDAFIILDDADWDQLEKVLYFSRLYNA 259 Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKDFY-GEDAKQSRDYGRIINDRHFQRVKGLID 299 GQ C + + ++ E L K K G+ + + + V I Sbjct: 260 GQVCTSSKRFIVLDKDYDRFKELLTKVFKTAKWGDPMDPETTLAPLSSAQAKADVLDQIK 319 Query: 300 -----NQKVAHGGT-WDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQ 353 ++ +GG D ++ PTI+ + +P+ +EIFGPV I V S EEAI+ Sbjct: 320 LALDHGAELVYGGEAIDHPGHFVMPTIIAGLTKDNPIYYQEIFGPVGEIYKVSSEEEAIE 379 Query: 354 FINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAY 413 N L +FS+N++ K + A+ +G N ++P LPFGG+ +SG G Sbjct: 380 VANDSNYGLGGTIFSSNQEHAKAVAAKIETGMSFINSGWT--SLPELPFGGIKHSGYGRE 437 Query: 414 HGKKSFETFSHRRSCLVKSLLNEE 437 + F +F + + + N Sbjct: 438 LSELGFTSFVNEHLIYIPNKTNNS 461 >4YWE-A nrPDB Length = 487 Score = 396 bits (1018), Expect = e-110, Method: Composition-based stats. Identities = 121/427 (28%), Positives = 190/427 (44%), Gaps = 20/427 (4%) Query: 18 GKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEELDTTIKE 77 S R + L L + ++++ ++ A D GK + + A + Sbjct: 66 WGAASAAERGRVLMRLSARVTDSIEELAAIEARDTGKPLKQARADAAALA-----RYFEF 120 Query: 78 LPDWAEDEPVAKTRQTQQDD-LYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVI 136 A D+ +T Q + EP GV I WNYP + + + A+AAGNA + Sbjct: 121 YAG-AADKLHGETLPYQAGYTVLTVREPHGVTGHIVPWNYPMQIFGRSVGAALAAGNACV 179 Query: 137 LKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKER--FDHIMYTGSTAVG 193 +KP+E + +A L + + +V G E L DHI +TGS A G Sbjct: 180 VKPAEDACLSVLRVAELAAEAGLPAGALNIVTGYGHEAGAALARHPGIDHISFTGSPATG 239 Query: 194 KIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCD 253 K+V AA++ PVTLELGGKSP V D DLD A + N GQTC A +L + Sbjct: 240 KLVTQMAAENHVPVTLELGGKSPQIVFADADLDAALPVLVSAIVQNGGQTCSAGSRVLIE 299 Query: 254 PSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQK------VAHG- 306 ++ +VE+L + ++ D G +IN + QRV + + + AHG Sbjct: 300 RAVYEPLVERLATAFNGLRVGPSRADLDCGPLINAKQQQRVWDFLSDAQHDGIPMAAHGQ 359 Query: 307 --GTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLAL 364 +S Y AP +L DV P + QEE+FGPV+ + +EA+ N L Sbjct: 360 VVADAPESGFYQAPALLRDVPPSHRLAQEEVFGPVLAAMRFVDEDEAVALANGTPYGLVA 419 Query: 365 YVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSH 424 +++ + ++ +G V N+ V LPFGGVG+SG G G ++ F+ Sbjct: 420 GIWTRDGARQMRLARRLRAGQVFINNYGAGGGV-ELPFGGVGHSGHGREKGFEALYGFTA 478 Query: 425 RRSCLVK 431 ++ ++ Sbjct: 479 LKTIAIR 485 >5NNO-A nrPDB Length = 546 Score = 396 bits (1017), Expect = e-110, Method: Composition-based stats. Identities = 207/463 (44%), Positives = 289/463 (62%), Gaps = 18/463 (3%) Query: 1 MSSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 + +I V + REAFN R L+ R Q L +L ++ EN A+ D ++ + Sbjct: 14 LENIPVIVSKCREAFNDDANRDLKKRKQVLRSLLNLVEENTDEFCKAIHRDRRRHRDETV 73 Query: 61 YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNL 120 E+ + E+ I+ + ++ + DD + EPLGVVLVIG WNYP L Sbjct: 74 VMEILPLRNEVWHLIEHMDEYVKPVKPTMEGAAALDDCELQYEPLGVVLVIGTWNYPLLL 133 Query: 121 TIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLKER 180 +QP++GA+AAGN ++KPSE++ A+LL L+P+Y+ ++ +V GGV ETT +LKER Sbjct: 134 ILQPLLGALAAGNTAVIKPSELAPATAELLTKLLPKYVSSDVVGIVNGGVSETTAVLKER 193 Query: 181 FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDC--DLDVACRRIAWGKFM 238 FDHI+YTGS V +IVMAAAAKHLTPVTLELGGKSP VD C ++ V RI WGK + Sbjct: 194 FDHILYTGSARVAEIVMAAAAKHLTPVTLELGGKSPVVVDDTCADNMKVVAERIMWGKII 253 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGED----------------AKQSRDY 282 N+GQT +APDY++ + S+++ +V+ L ++ K G+ + DY Sbjct: 254 NAGQTSIAPDYVVVEKSMESVLVDALAEARKAMLGDKFLKVLKGELLVKQKQQFLEESDY 313 Query: 283 GRIINDRHFQRVKGLIDNQKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPI 342 RI+N HFQR+ + KVA GG D+++ IAPTIL ++DP PVMQEEIFGP++P+ Sbjct: 314 PRIVNASHFQRLMEFMKGGKVAVGGEADEATLTIAPTILTNIDPTHPVMQEEIFGPILPV 373 Query: 343 VCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPF 402 + + ++ ++ IN REKPLALYVFSNN++ I+ + + TSSG V NDV+VH LPF Sbjct: 374 LTYENEKDILKIINSREKPLALYVFSNNKRFIRGVESRTSSGAVVVNDVVVHAGADGLPF 433 Query: 403 GGVGNSGMGAYHGKKSFETFSHRRSCLVKSLLNEEAHKARYPP 445 GGVG SGMGAYHG+ SFETFSHRR + + L R+PP Sbjct: 434 GGVGRSGMGAYHGRYSFETFSHRRPVMRRGFLFSSIDTVRFPP 476 >2QE0-A nrPDB Length = 475 Score = 394 bits (1013), Expect = e-110, Method: Composition-based stats. Identities = 107/436 (24%), Positives = 188/436 (43%), Gaps = 12/436 (2%) Query: 2 SSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 + A++A + + S R L + ++ + + I L+ ++ K S Sbjct: 40 EEVDYVYASAKKAQPAWRALSYIERAAYLHKVADILMRDKEKIGAILSKEVAKGY-KSAV 98 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQ--TQQDDLYIHSEPLGVVLVIGAWNYPFN 119 EV E ++ +E + + + +++ + EP+G+VL I +NYP N Sbjct: 99 SEVVRTAEIINYAAEEGLRMEGEVLEGGSFEAASKKKIAVVRREPVGLVLAISPFNYPVN 158 Query: 120 LTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLK 178 L + A+ AGN + KP LLA + + ++ + G E + + Sbjct: 159 LAGSKIAPALIAGNVIAFKPPTQGSISGLLLAEAFAEAGLPAGVFNTITGRGSEIGDYIV 218 Query: 179 ER--FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGK 236 E + I +TGST +G+ + A + P+ L LGGK V +D DL++ + I G Sbjct: 219 EHQAVNFINFTGSTGIGERIGKMAG--MRPIMLALGGKDSAIVLEDADLELTAKNIIAGA 276 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKG 296 F SGQ C A +L S+ +++VEK+++ + + + D +I+ + V+G Sbjct: 277 FGYSGQRCTAVKRVLVMESVADELVEKIREKVLALTIGNPEDDADITPLIDTKSADYVEG 336 Query: 297 LIDNQ---KVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQ 353 LI++ + I P + V + EE FGPV+PI+ V S+EEAI+ Sbjct: 337 LINDANDKGATALTEIKREGNLICPILFDKVTTDMRLAWEEPFGPVLPIIRVTSVEEAIE 396 Query: 354 FINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAY 413 N+ E L +F+N+ + + G V N+ PF G SG G Sbjct: 397 ISNKSEYGLQASIFTNDFPRAFGIAEQLEVGTVHINNK-TQRGTDNFPFLGAKKSGAGIQ 455 Query: 414 HGKKSFETFSHRRSCL 429 K S E + +S + Sbjct: 456 GVKYSIEAMTTVKSVV 471 >2J5N-A nrPDB Length = 516 Score = 393 bits (1011), Expect = e-110, Method: Composition-based stats. Identities = 102/429 (23%), Positives = 176/429 (41%), Gaps = 18/429 (4%) Query: 15 FNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEELDTT 74 F + K + R + L ++ + + L ++GKN W +VA ++ ++ Sbjct: 87 FKTWKDWPQEDRSRLLLKAAALMRRRKRELEATLVYEVGKN-WVEASADVAEAIDFIEYY 145 Query: 75 IKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNA 134 + + P + +D PLG +VI WN+P + +VG VA GN Sbjct: 146 ARAALRYRY--PAVEVVPYPGEDNESFYVPLGAGVVIAPWNFPVAIFTGMIVGPVAVGNT 203 Query: 135 VILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKER--FDHIMYTGSTA 191 VI KP+E + + + + + + + G E L E I +TGS Sbjct: 204 VIAKPAEDAVVVGAKVFEIFHEAGFPPGVVNFLPGVGEEVGAYLVEHPRIRFINFTGSLE 263 Query: 192 VGKIVMAAAAKH------LTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCV 245 VG + AA + +E GGK VD+ D D+A + + GQ C Sbjct: 264 VGLKIYEAAGRLAPGQTWFKRAYVETGGKDAIIVDETADFDLAAEGVVVSAYGFQGQKCS 323 Query: 246 APDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQK--- 302 A ++ ++E++ K + A+++ D G +++ ++V I+ K Sbjct: 324 AASRLILTQGAYEPVLERVLKRAERLSVGPAEENPDLGPVVSAEQERKVLSYIEIGKNEG 383 Query: 303 --VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREK 360 V G + +IAPT+ +V P++ + QEEIFGPV+ ++ V+ EA++ N Sbjct: 384 QLVLGGKRLEGEGYFIAPTVFTEVPPKARIAQEEIFGPVLSVIRVKDFAEALEVANDTPY 443 Query: 361 PLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHG-KKSF 419 L V+S + ++ E G + N I V PFGG SG A G Sbjct: 444 GLTGGVYSRKREHLEWARREFHVGNLYFNRKITGALVGVQPFGGFKLSGTNAKTGALDYL 503 Query: 420 ETFSHRRSC 428 F ++ Sbjct: 504 RLFLEMKAV 512 >2W8P-A nrPDB Length = 487 Score = 393 bits (1009), Expect = e-109, Method: Composition-based stats. Identities = 107/429 (24%), Positives = 185/429 (43%), Gaps = 20/429 (4%) Query: 15 FNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEELDTT 74 F + S + R L ++ +N ++ + ++ GK + + E+ + L+ Sbjct: 61 FCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-HGEILYSAFFLEWF 119 Query: 75 IKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNA 134 +E D + + +P+GV VI WN+P + + + A+AAG Sbjct: 120 SEEARRVYGDIIHT---PAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCT 176 Query: 135 VILKPSEVSGHMADLLATLIPQY-MDQNLYLVVK---GGVPETTELL--KERFDHIMYTG 188 V++KP+E + A LA L Q + +Y V+ E E + I +TG Sbjct: 177 VVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTG 236 Query: 189 STAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPD 248 ST GKI++ AA + V++ELGG +P V ++D A KF N+GQT V + Sbjct: 237 STTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTAVCSN 296 Query: 249 YILCDPSIQNQIVEKLKKSLKD--FYGEDAKQSRDYGRIINDRHFQRVKGLI-----DNQ 301 L I + V+ +++K G ++ G +IN++ ++V+ + Sbjct: 297 QFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGA 356 Query: 302 KVAHGGTWDQSS-RYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREK 360 V GG Q + PT+L +V EE FGP+ P++ + EEAI N + Sbjct: 357 TVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADV 416 Query: 361 PLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFE 420 LA Y +S + I ++ + G V N+ ++ PFGGV SG+G K + Sbjct: 417 GLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSV--ECPFGGVKQSGLGREGSKYGID 474 Query: 421 TFSHRRSCL 429 + + Sbjct: 475 EYLELKYVC 483 >5X5U-A nrPDB Length = 505 Score = 388 bits (998), Expect = e-108, Method: Composition-based stats. Identities = 106/432 (24%), Positives = 182/432 (42%), Gaps = 16/432 (3%) Query: 12 REAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEEL 71 + F + + R + ++ E +I+ + + GK + EV + + Sbjct: 80 QSGFEAWRKVPAHERAATMRKAAALVRERADAIAQLMTQEQGKPLTEARV-EVLSAADII 138 Query: 72 DTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAA 131 + + + + EP+G V WN+P N ++ + A+A Sbjct: 139 EWFAD---EGRRVYGRIVPPRNLGAQQTVVKEPVGPVAAFTPWNFPVNQVVRKLSAALAT 195 Query: 132 GNAVILK-PSEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLKER--FDHIMYTG 188 G + ++K P E A LL + + + +V G E + L + +TG Sbjct: 196 GCSFLVKAPEETPASPAALLRAFVDAGVPAGVIGLVYGDPAEISSYLIPHPVIRKVTFTG 255 Query: 189 STAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPD 248 ST VGK + + A H+ T+ELGG +P V +D D+ +A + KF N+GQ C++P Sbjct: 256 STPVGKQLASLAGLHMKRATMELGGHAPVIVAEDADVALAVKAAGGAKFRNAGQVCISPT 315 Query: 249 YILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGLIDNQK----- 302 L SI+++ L K + G ++ G + N R + +IDN + Sbjct: 316 RFLVHNSIRDEFTRALVKHAEGLKVGNGLEEGTTLGALANPRRLTAMASVIDNARKVGAS 375 Query: 303 VAHGGTWDQS-SRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKP 361 + GG S + APT++ +V + V E FGPV I LEEAI N+ Sbjct: 376 IETGGERIGSEGNFFAPTVIANVPLDADVFNNEPFGPVAAIRGFDKLEEAIAEANRLPFG 435 Query: 362 LALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFET 421 LA Y F+ + + + G + N P +PFGGV +SG G+ G ++ E Sbjct: 436 LAGYAFTRSFANVHLLTQRLEVGMLWINQPATPW--PEMPFGGVKDSGYGSEGGPEALEP 493 Query: 422 FSHRRSCLVKSL 433 + +S V ++ Sbjct: 494 YLVTKSVTVMAV 505 >3RH9-A nrPDB Length = 506 Score = 385 bits (989), Expect = e-107, Method: Composition-based stats. Identities = 109/438 (24%), Positives = 187/438 (42%), Gaps = 17/438 (3%) Query: 2 SSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 + V+ + A ++ R + LE ++ + EN + I L + GK W Sbjct: 49 EDVVAAVEAGQSALRLTNPWPIETRRKWLEDIRDGLKENREEIGRILCMEHGKP-WKEAQ 107 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLT 121 EV + D K + K + +H P+GV +I WN+P + Sbjct: 108 GEVDYAAGFFDYCAKHISALDSHTIPEKPKDC---TWTVHYRPVGVTGLIVPWNFPIGMI 164 Query: 122 IQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKER 180 + + A+AAG ++KP+ + +++ + + + +V G ++L E Sbjct: 165 AKKLSAALAAGCPSVIKPASETPLTMIAFFSVMDKLDLPDGMVNLVMGKASVIGKVLCEH 224 Query: 181 --FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFM 238 + +TGST VG+ ++ A+ + + LELGG +P V D DL+ A + KF Sbjct: 225 KDVPMLSFTGSTEVGRKLIVDTAEQVKKLALELGGNAPFIVFDDADLEAAADNLIANKFR 284 Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSL-KDFYGEDAKQSRDYGRIINDRHFQRVKGL 297 GQTCV + I + + +KL + + K G+ D G +IN + F +VK Sbjct: 285 GGGQTCVCANRIFVHEKVADAFGQKLAERVNKMTVGDGMNDGIDIGPLINKQGFDKVKRH 344 Query: 298 I-----DNQKVAHGGTWDQ--SSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEE 350 + + G + + PT++ VD + QEE FGP++P+ R+ EE Sbjct: 345 LQDALDKGASLVAGKQPAELGDGLFFPPTVVQGVDREMCCYQEETFGPLVPMALFRTEEE 404 Query: 351 AIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGM 410 I N E LA YVF+ + + +++ A G V N P PFGG+ SG+ Sbjct: 405 VIDAGNDTEFGLASYVFTADAERAQRVAAGLRFGHVGWNTGT--GPTPEAPFGGMKASGI 462 Query: 411 GAYHGKKSFETFSHRRSC 428 G G + F ++ Sbjct: 463 GREGGLEGLFEFVEAQTV 480 >3R64-A nrPDB Length = 508 Score = 383 bits (985), Expect = e-107, Method: Composition-based stats. Identities = 106/443 (23%), Positives = 193/443 (43%), Gaps = 15/443 (3%) Query: 1 MSSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 ++ + + A++A R + ++ E+ + I L + G + Sbjct: 49 IADVDAAYEAAKKAQAEWAATPAAERSAIIYRAAELLEEHREEIVEWLIKESGSTRSKAN 108 Query: 61 YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNL 120 E + + P +++ +Y GVV VI WN+P NL Sbjct: 109 LE--ITLAGNITKESASFPGRVHGRISPSNTPGKENRVY--RVAKGVVGVISPWNFPLNL 164 Query: 121 TIQPMVGAVAAGNAVILKPSEVSGHMADLL-ATLIPQY-MDQNLYLVVKGGVPETTELLK 178 +I+ + A+A GNAV++KP+ + ++ A + + + + V G E + Sbjct: 165 SIRSVAPALAVGNAVVIKPASDTPVTGGVIPARIFEEAGVPAGVISTVAGAGSEIGDHFV 224 Query: 179 ER--FDHIMYTGSTAVGKIVMAAA--AKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAW 234 I +TGST VG+ V A + V LELGG +P V D D+D A + A Sbjct: 225 THAVPKLISFTGSTPVGRRVGELAINGGPMKTVALELGGNAPFVVLADADIDAAAQAAAV 284 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQR 293 G F++ GQ C++ + ++ D ++ ++ +EK +++K+ G+ + + G +IND Sbjct: 285 GAFLHQGQICMSINRVIVDAAVHDEFLEKFVEAVKNIPTGDPSAEGTLVGPVINDSQLSG 344 Query: 294 VKGLIDNQKVAHGG---TWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEE 350 +K I+ K R + P + DV + +EEIFGP++ ++ Sbjct: 345 LKEKIELAKKEGATVQVEGPIEGRLVHPHVFSDVTSDMEIAREEIFGPLISVLKADDEAH 404 Query: 351 AIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGM 410 A + N + L+ V+S + + + SG V ND+ V+ P + FGG NSG+ Sbjct: 405 AAELANASDFGLSAAVWSKDIDRAAQFALQIDSGMVHINDLTVNDE-PHVMFGGSKNSGL 463 Query: 411 GAYHGKKSFETFSHRRSCLVKSL 433 G ++G + E F+ R +K Sbjct: 464 GRFNGDWAIEEFTTDRWIGIKRS 486 >3EFV-A nrPDB Length = 462 Score = 382 bits (981), Expect = e-106, Method: Composition-based stats. Identities = 101/436 (23%), Positives = 174/436 (39%), Gaps = 16/436 (3%) Query: 3 SISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE 62 I + A F K S+ R Q L + + + + + ++ + ++GK + Sbjct: 30 EIEHALSLAASGFKKWKMTSVAQRAQTLRDIGQALRAHAEEMAQCITREMGKPIKQAR-A 88 Query: 63 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTI 122 EV D + P EP + I PLGV+L I WN+P + Sbjct: 89 EVTKSAALCDWYAEHGPAMLNPEPTL----VENQQAVIEYRPLGVILAIMPWNFPLWQVL 144 Query: 123 QPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYM-DQNLYLVVKGGVPETTELL-KER 180 + V + AGN+ +LK + A ++A ++ + +Y V ++++ R Sbjct: 145 RGAVPILLAGNSYLLKHAPNVTGCAQMIARILAEAGTPAGVYGWVNANNEGVSQMINDPR 204 Query: 181 FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNS 240 + TGS G + A A L LELGG P V D DL++A + G++ N+ Sbjct: 205 IAAVTVTGSVRAGAAIGAQAGAALKKCVLELGGSDPFIVLNDADLELAVKAAVAGRYQNT 264 Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRII-----NDRHFQRV 294 GQ C A + + I ++ + G+ + D G + ++ H Q Sbjct: 265 GQVCAAAKRFIVEEGIAQAFTDRFVAAAAALKMGDPLVEENDLGPMARFDLRDELHQQVQ 324 Query: 295 KGLIDNQKVAHGGT-WDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQ 353 + + ++ GG Y A T+L DV P ++E+FGPV I + A+ Sbjct: 325 ASVAEGARLLLGGEKIAGEGNYYAATVLADVTPDMTAFRQELFGPVAAITVAKDAAHALA 384 Query: 354 FINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAY 413 N E L+ +F+ ++ + +M A GGV N + + FGGV SG G Sbjct: 385 LANDSEFGLSATIFTADDTLAAEMAARLECGGVFING--YSASDARVAFGGVKKSGFGRE 442 Query: 414 HGKKSFETFSHRRSCL 429 F + ++ Sbjct: 443 LSHFGLHEFCNVQTVW 458 >5VBF-A nrPDB Length = 478 Score = 378 bits (970), Expect = e-105, Method: Composition-based stats. Identities = 109/437 (24%), Positives = 187/437 (42%), Gaps = 16/437 (3%) Query: 3 SISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE 62 I V+ A AF + + S R L + E ++I + D GK + Sbjct: 45 DIDAAVQAAHRAFVTWRHESPLVRSDLLRRAAALARERAETIGRHITMDQGKPLREA-IA 103 Query: 63 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTI 122 EV E+L+ +E A++ Q + EP+GV WN+PF+ + Sbjct: 104 EVVSAAEQLEWHAEEGRRTYGRVVPARSPDVMQT---VLREPIGVCAAFSPWNFPFSQAM 160 Query: 123 QPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKE-- 179 + A+A+G ++LK E S LA L + +V G + ++ L E Sbjct: 161 HKIAAALASGCTLVLKGPEESPSAIVALAQLFHDAGLPPGCLNIVWGVPGDVSKQLIEAP 220 Query: 180 RFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMN 239 + I +TGS VGK + A AA + +T+ELGG +P V D D++ A +A KF N Sbjct: 221 QVRKISFTGSVPVGKQLAALAASLMKRMTMELGGHAPVLVCADADVERAAAMLAAYKFRN 280 Query: 240 SGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGLI 298 +GQ CV+P + ++ V ++ G G + + R + + Sbjct: 281 AGQVCVSPTRFFVQRAAFDRFVCAYLDAVGTIRVGYGLDAGVTMGPLAHARRVDEIDAFV 340 Query: 299 -----DNQKVAHGG-TWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAI 352 ++A GG Y APT+++ + +M +E FGP++ IV L++A+ Sbjct: 341 ADATAKGAQIATGGMRLPGPGHYFAPTVVLGPTRDTRLMNDEPFGPIVGIVPFDDLDDAL 400 Query: 353 QFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGA 412 N+ LA Y F+ + + ++ +G V N + +PFGGV +SG G+ Sbjct: 401 AEANRLPFGLASYAFTTSARNAHRISRALEAGMVNINH--FGMGPAEIPFGGVKDSGFGS 458 Query: 413 YHGKKSFETFSHRRSCL 429 G ++F+ + + Sbjct: 459 EGGMEAFDGYLVTKFVT 475 >3ROS-A nrPDB Length = 484 Score = 377 bits (969), Expect = e-105, Method: Composition-based stats. Identities = 98/450 (21%), Positives = 172/450 (38%), Gaps = 17/450 (3%) Query: 3 SISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE 62 I + + A + + R + L + + E+ ++ + ++GK S E Sbjct: 27 QIDEAINLAHALYKKWRHEEPASRAEILHDIANALKEHEDELAKMMTLEMGKLLSES-KE 85 Query: 63 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTI 122 EV + + P+ + + + Y + GV++ WN+P I Sbjct: 86 EVELCVSICNYYADHGPEMLKPTKLNS----DLGNAYYLKQSTGVIMACEPWNFPLYQVI 141 Query: 123 QPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQN-LYLVVKGGVPETTELLKER 180 + GN ++LK + A L A +I + + L + + R Sbjct: 142 RVFAPNFIVGNPILLKHAHNVPGSAALTAKIIKRAGAPEGSLINLYPSYDQLADIIADPR 201 Query: 181 FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNS 240 + TGS G V AA K+L T+ELGG V D D V + + N Sbjct: 202 IQGVALTGSERGGSAVAEAAGKNLKKSTMELGGNDAFIVLDDADPQVLRNVLNDARTYND 261 Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKDFY-GEDAKQSRDYGRIINDRHFQR----VK 295 GQ C + I+ + S ++++ +LK + G+ + + +++ ++ VK Sbjct: 262 GQVCTSSKRIIVEKSRYDEVLHELKNVFSNLKAGDPLEADTTLPPMNSEKAKEKLEAQVK 321 Query: 296 GLID-NQKVAHG-GTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQ 353 ID KV + D + PTIL D+ +PV +E+FGP+ + V AIQ Sbjct: 322 EAIDAGAKVFYQYPEIDSKGAFFRPTILTDIAKDNPVFDKEVFGPIAEVFVVEDDNAAIQ 381 Query: 354 FINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAY 413 N L V ++ KK+ A+ +G N + T LPFGG+ SG G Sbjct: 382 LANDSSYGLGSSVIGSDIDRAKKVSAQIETGMTVINGRWI--TSGELPFGGIKKSGYGRE 439 Query: 414 HGKKSFETFSHRRSCLVKSLLNEEAHKARY 443 F + ++ N +A + Sbjct: 440 LSGLGLMAFVNE-HLVIDVTKNNQAENLYF 468 >5N5S-A nrPDB Length = 515 Score = 375 bits (963), Expect = e-104, Method: Composition-based stats. Identities = 93/422 (22%), Positives = 184/422 (43%), Gaps = 17/422 (4%) Query: 25 FRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEELDTTIKELPD-WAE 83 R LE + + + I+ L + GK + EV ++ +E + E Sbjct: 99 ERKAVLEKVVAELKNRFEEIAQTLTMESGKPIKDAR-GEVTRTIDTFQVAAEESVRIYGE 157 Query: 84 DEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVS 143 P+ + + + + P+G V ++ WN+P NL + A+A G +LKP+ + Sbjct: 158 HIPLDISARNKGLQGIVKKFPIGPVSMVSPWNFPLNLVAHKVAPAIAVGCPFVLKPASRT 217 Query: 144 GHMADLLATLIP--QYMDQNLYLVVKGGVPETTEL-LKERFDHIMYTGSTAVGKIVMAAA 200 A +L ++ + + + ++ + + ERF + +TGS +G + A A Sbjct: 218 PLSALILGEILHKIEELPLGAFSILPVSREDADMFTVDERFKLLTFTGSGPIGWDMKARA 277 Query: 201 AKHLTPVTLELGGKSPCYVDKDC-DLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQ 259 K V +ELGG +PC VD DLD +R+ G F GQ+C+ + + ++ Sbjct: 278 GK--KKVVMELGGNAPCIVDDYVPDLDYTIQRLINGGFYQGGQSCIHMQRLYVHERLYDE 335 Query: 260 IVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGLID-----NQKVAHGGTWDQSS 313 + E ++K G ++ G +I++ + ++ + K+ GG ++ Sbjct: 336 VKEGFVAAVKKLKMGNPFEEDTYLGPMISESAAKGIEDWVKEAVAKGGKLLTGG--NRKG 393 Query: 314 RYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKV 373 +I PT++ DV ++ +EEIFGPV+ + +EA++ N L +F+ + Sbjct: 394 AFIEPTVIEDVPIEANARKEEIFGPVVLLYKYSDFKEAVKECNNTHYGLQSGIFTKDLNK 453 Query: 374 IKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVKSL 433 GGV ND + V + P+GG+ +SG+ K + + + +++++ Sbjct: 454 AFYAFEHMEVGGVILNDSPA-LRVDSQPYGGLKDSGIQREGVKYAMDDMLETKVLVMRNV 512 Query: 434 LN 435 Sbjct: 513 GT 514 >5KF0-A nrPDB Length = 485 Score = 375 bits (963), Expect = e-104, Method: Composition-based stats. Identities = 109/433 (25%), Positives = 187/433 (43%), Gaps = 17/433 (3%) Query: 10 RAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLE 69 A +A + R L+ E ++ AL + GK S EV +++ Sbjct: 57 AAVDAVKPMRELPAYRRQAVLDHCVARFRERFDELAEALCIEAGKPINDSR-GEVTRLID 115 Query: 70 ELDTTIKELPDWAEDEP-VAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGA 128 +E + + + + Q Y P+G I +N+P NL + A Sbjct: 116 TFRVASEEAVRIDGEVLNLEISARAQGYTGYTRRVPIGPCSFISPFNFPLNLAAHKVAPA 175 Query: 129 VAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELL-KERFDHIMY 186 +AAG +LKP+ + A ++A ++ + + + + V+ ERF + + Sbjct: 176 LAAGCPFVLKPASRTPVGALIIAEVLAETNLPKGAFSVLPAHRDGADLFTTDERFRLLSF 235 Query: 187 TGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDC--DLDVACRRIAWGKFMNSGQTC 244 TGS AVG + A K V LELGG + VD D LD R+A+G + SGQ+C Sbjct: 236 TGSPAVGWALKEKAGK--KKVVLELGGNAAAIVDADQFEQLDYVVDRLAFGAYYQSGQSC 293 Query: 245 VAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGLID---- 299 + IL S+ + + +KL + G+ S G +I++ +R+ G +D Sbjct: 294 IGVQRILVHASLYDTLRDKLVAKTRSLKMGDPKDPSTFVGPMISESESRRLSGWMDAAVA 353 Query: 300 -NQKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQR 358 K+ GG D T+L DV + + ++E FGPV + ++A+ +N Sbjct: 354 AGAKIIAGGKVD--GAMFEATLLEDVGREQDLYRKEAFGPVAILEKFDRFDDALARVNDS 411 Query: 359 EKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKS 418 + L VF+++ ++ E GGV NDV V +P+GGV +SG+G + + Sbjct: 412 DFGLQAGVFTDSLTHAQRAWDELEVGGVVINDVP-SFRVDNMPYGGVKDSGLGREGIRYA 470 Query: 419 FETFSHRRSCLVK 431 E + R +V+ Sbjct: 471 IEDMTEPRLMVVR 483 >4PXN-A nrPDB Length = 525 Score = 373 bits (959), Expect = e-104, Method: Composition-based stats. Identities = 89/444 (20%), Positives = 183/444 (41%), Gaps = 21/444 (4%) Query: 3 SISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE 62 + ++ +A + R + + + + L + ++ ++GK Sbjct: 74 DYEEGMRACFDAAKTWMAIPAPKRGEIVRQIGDALRAKLHHLGRLVSLEMGKILPEG-IG 132 Query: 63 EVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTI 122 EV +++ D + ++ +++ PLGVV VI A+N+P + Sbjct: 133 EVQEIIDMCDYAVGLSRQLNGSIIPSERPNHMMMEVW---NPLGVVGVITAFNFPCAVLG 189 Query: 123 QPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMDQN-----LYLVVKGGVPETTE-L 176 A+ GN V+ K + + + + ++ +++N ++ GG Sbjct: 190 WNACIALVCGNCVVWKGAPTTPLITIAMTKIVASVLEKNNLPGAIFTSFCGGTEIGQAIA 249 Query: 177 LKERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGK 236 L R + +TGST G +V + LEL G + V D D+ +A R + + Sbjct: 250 LDIRIPLVSFTGSTRAGLMVQQQVSARFGKCLLELSGNNAIIVMDDADIQLAVRSVLFAA 309 Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVK 295 +GQ C ++ +I +++L + K G+ ++ G + + Sbjct: 310 VGTAGQRCTTCRRLILHENIYQTFLDQLVEVYKQVRIGDPLEKGTLLGPLHTPASKENFL 369 Query: 296 GLI-----DNQKVAHGGTWDQS-SRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLE 349 I K+ GG+ +S ++ PTI+ ++ P +PV++EE+FGPV+ ++ ++L+ Sbjct: 370 KGIQTIKSQGGKILFGGSAIESEGNFVQPTIV-EITPSAPVVKEELFGPVLYVMKFQTLK 428 Query: 350 EAIQFINQREKPLALYVFSNNEKVIKKMI--AETSSGGVTANDVIVHITVPTLPFGGVGN 407 EAI+ N + L+ +F+ +I K + + G V N + FGG Sbjct: 429 EAIEINNSVPQGLSSSIFTKRPDIIFKWLGPHGSDCGIVNVNIPTNGAEIGG-AFGGEKA 487 Query: 408 SGMGAYHGKKSFETFSHRRSCLVK 431 +G G G S++ + R +C + Sbjct: 488 TGGGREAGSDSWKQYMRRATCTIN 511 >5U0M-A nrPDB Length = 497 Score = 371 bits (953), Expect = e-103, Method: Composition-based stats. Identities = 97/433 (22%), Positives = 187/433 (43%), Gaps = 22/433 (5%) Query: 1 MSSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 + + V+ AR+AF + + +SL R +EA ++ N + ++ + + GK W S Sbjct: 47 LEDVDAAVREARKAFLAWRRKSLAERQAVIEAFGELLEANKEELAHQIGLETGKPLWESR 106 Query: 61 YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNL 120 EVA ++ ++ ++K + + P GVV V G +N+P +L Sbjct: 107 -TEVAAMMGKIPISVKAYNERTGHTE----SDVAGGHAVLRHRPHGVVAVFGPYNFPGHL 161 Query: 121 TIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKE 179 +V A+ AGN V+ KPSE++ +A+L L + + + +V+GG L + Sbjct: 162 PNGHIVPALLAGNTVVFKPSELTPGVAELTVRLWEKAGLPDGVINLVQGGSDTGKCLARH 221 Query: 180 R-FDHIMYTGSTAVGKIVMAA-AAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKF 237 D + +TGS+ VG ++ + + LE+GG +P V DLD A F Sbjct: 222 SLIDGLFFTGSSTVGHLLHEQFGGQPEKILALEMGGNNPLIVQNVSDLDGAVHHALQSAF 281 Query: 238 MNSGQTCVAPDYILCDPSIQ-NQIVEKLKKSLKDFYGE--DAKQSRDYGRIINDRHFQRV 294 +++GQ C +L + ++ + +L + DA G +I+ ++ Sbjct: 282 LSAGQRCTCARRLLVPKGKKGDEFLARLVEVAARITVAEFDADPQPFMGSVISAEAANQL 341 Query: 295 KGLIDNQKVAHGGT-------WDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRS 347 + G T + ++P I+ + + +E FGP++ + + Sbjct: 342 LKA-QAAMLEKGATSLLEMKQLKPDTGLLSPGIVDATGIE--LEDQEFFGPLLTVYRYKG 398 Query: 348 LEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGN 407 +EA++ N L+ + S++ K+ +++ E +G V N + + PFGGVG Sbjct: 399 FDEALELANNTRYGLSAGILSDDRKLYNRLVEEVRAGIVNWNRPLTGASSA-APFGGVGA 457 Query: 408 SGMGAYHGKKSFE 420 SG + + Sbjct: 458 SGNHRPSAYYAAD 470 >5JRY-A nrPDB Length = 485 Score = 369 bits (947), Expect = e-102, Method: Composition-based stats. Identities = 105/433 (24%), Positives = 184/433 (42%), Gaps = 17/433 (3%) Query: 10 RAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLE 69 A +A + R L+ E ++ AL + GK + EV +++ Sbjct: 57 AAVDATKPMRELPAYKRQAVLDHCVARFRERFDELAEALCIEAGKPINDA-KGEVTRLID 115 Query: 70 ELDTTIKELPDWAEDEP-VAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGA 128 +E + + + + Q Y P+G I +N+P NL + A Sbjct: 116 TFRVASEEAVRIDGEVLNLEISARAQGYTGYTRRVPIGPCSFISPFNFPLNLAAHKVAPA 175 Query: 129 VAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELL-KERFDHIMY 186 +AAG +LKP+ + A ++ ++ + + + + V+ +RF + + Sbjct: 176 LAAGCPFVLKPASRTPVGALIIGEVLAETDLPKGAFSVLPAHRDGADLFTTDDRFRLLSF 235 Query: 187 TGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDC--DLDVACRRIAWGKFMNSGQTC 244 TGS AVG + A K V LELGG + VD D LD R+A+G F SGQ+C Sbjct: 236 TGSPAVGWALKEKAGK--KKVVLELGGNAAAIVDADQLDRLDYVVDRLAFGAFYQSGQSC 293 Query: 245 VAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGLID---- 299 + IL I + + +KL + G+ S G +I++ +R+ G +D Sbjct: 294 IGVQRILAHADIYDALRDKLIAKTRSLKMGDPKDPSTFVGPMISESESRRLSGWMDAAVA 353 Query: 300 -NQKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQR 358 K+ GG D T+L +V + ++E FGP+ + ++A+ +N Sbjct: 354 AGAKIVAGGKVD--GAMFEATLLENVGRDQDLYRKEAFGPIAILEKFDRFDDALARVNDS 411 Query: 359 EKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKS 418 + L VF+++ ++ E GGV NDV V +P+GGV +SG+G + + Sbjct: 412 DFGLQAGVFTDSLAHTQQAWDELEVGGVVINDVP-SFRVDNMPYGGVKDSGLGREGIRYA 470 Query: 419 FETFSHRRSCLVK 431 E + R +V+ Sbjct: 471 IEDMTEPRLLVVR 483 >4E4G-A nrPDB Length = 521 Score = 365 bits (937), Expect = e-101, Method: Composition-based stats. Identities = 93/431 (21%), Positives = 179/431 (41%), Gaps = 21/431 (4%) Query: 15 FNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEELDTT 74 + Q R + +++N+N+ ++ L+ + GK + ++ LE + Sbjct: 77 QPKWAATNPQRRARVFMKFVQLLNDNMNELAEMLSREHGKTIDDA-KGDIVRGLEVCEFV 135 Query: 75 IKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNA 134 I +P + E D+Y +P+G+ I +N+P + + A+A GNA Sbjct: 136 IG-IPHLQKSEFTEGAGP--GIDMYSIRQPVGIGAGITPFNFPGMIPMWMFAPAIACGNA 192 Query: 135 VILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKE-RFDHIMYTGSTAV 192 ILKPSE + LA L+ + + + VV G +L + + GST + Sbjct: 193 FILKPSERDPSVPIRLAELMIEAGLPAGILNVVNGDKGAVDAILTHPDIAAVSFVGSTPI 252 Query: 193 GKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYIL- 251 + V AA + G K+ + D DLD A + + ++G+ C+A + Sbjct: 253 ARYVYGTAAMNGKRAQCFGGAKNHMIIMPDADLDQAANALIGAGYGSAGERCMAISVAVP 312 Query: 252 CDPSIQNQIVEKLKKSLKDFYGED-AKQSRDYGRIINDRHFQRVKGLID-----NQKVAH 305 N++++KL ++ + D G ++ QR++ LID K+ Sbjct: 313 VGEETANRLIDKLVPMVESLRIGPYTDEKADMGPVVTKEAEQRIRSLIDSGIEQGAKLVV 372 Query: 306 GG-----TWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREK 360 G ++ +I + DV P + + EIFGPV+ +V R+ EEA+ + E Sbjct: 373 DGRDFKLQGYENGHFIGGCLFDDVTPDMDIYKTEIFGPVLSVVRARNYEEALSLPMKHEY 432 Query: 361 PLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGA--YHGKKS 418 + +++ + + + + G V N V + + + FGG +S G HG S Sbjct: 433 GNGVAIYTRDGDAARDFASRINIGMVGVN-VPIPVPLAYHSFGGWKSSSFGDLNQHGTDS 491 Query: 419 FETFSHRRSCL 429 + ++ ++ Sbjct: 492 IKFWTRTKTIT 502 >5J6B-A nrPDB Length = 485 Score = 361 bits (928), Expect = e-100, Method: Composition-based stats. Identities = 102/429 (23%), Positives = 177/429 (41%), Gaps = 17/429 (3%) Query: 14 AFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEELDT 73 A + R LE E ++ AL + GK S EV +++ Sbjct: 61 AQKPLRALPAFRRQAILEHCVARFRERFDELAQALCIEAGKPINDS-KGEVTRLIDTFRV 119 Query: 74 TIKELPDWAEDEPVAKTRQTQQDDL-YIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAG 132 +E + Q Y P+G I +N+P NL + A+AAG Sbjct: 120 AAEESVRIEGGLVNLEISPRAQGYSGYYKRVPIGPCSFISPFNFPLNLAAHKVAPALAAG 179 Query: 133 NAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELL-KERFDHIMYTGST 190 +LKP+ + A ++ ++ + + + + ++ ERF + +TGS Sbjct: 180 CPFVLKPASRTPIGALIIGEVLAETDLPKGAFSILPAHRDGADLFTTDERFKLLSFTGSP 239 Query: 191 AVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCD--LDVACRRIAWGKFMNSGQTCVAPD 248 VG + A K V LELGG + VD D LD R+A+G + SGQ+C+ Sbjct: 240 TVGWELKKKAGKKK--VVLELGGNAAAIVDADQREVLDYVVERLAFGAYYQSGQSCIGVQ 297 Query: 249 YILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHFQRVKGLID-----NQK 302 I+ + + + EKL + G+ + G +I++ +R+ G ++ K Sbjct: 298 RIIAHADVYDALREKLIAKTRSLKMGDPKDPATFVGPMISESEARRLAGWMEAAVAAGAK 357 Query: 303 VAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPL 362 + GG D T+L V + ++E FGPV + ++A+ +N + L Sbjct: 358 IVAGGKVD--GAMFEATLLEGVGRDQDLYRKEAFGPVALLERFSDFDDALARVNDSDFGL 415 Query: 363 ALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYHGKKSFETF 422 VF+++ ++ E GGV NDV V +P+GGV +SG+G + + E Sbjct: 416 QAGVFTDSLSHAQRAWDELEVGGVVINDVP-SFRVDNMPYGGVKDSGLGREGIRYAIEDM 474 Query: 423 SHRRSCLVK 431 + R +V+ Sbjct: 475 TELRLMVVR 483 >3JU8-A nrPDB Length = 490 Score = 356 bits (913), Expect = 1e-98, Method: Composition-based stats. Identities = 100/423 (23%), Positives = 186/423 (43%), Gaps = 19/423 (4%) Query: 2 SSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 + + V AREAF + R L+ RI+ LE + ++ + + GK W S Sbjct: 42 TQVDAAVCAAREAFPAWARRPLEQRIELLERFAATLKSRADELARVIGEETGKPLWESA- 100 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLT 121 EV ++ ++ +++ + + K+ + +P GVV V G +N+P +L Sbjct: 101 TEVTSMVNKVAISVQAFRERTGE----KSGPLADATAVLRHKPHGVVAVFGPYNFPGHLP 156 Query: 122 IQPMVGAVAAGNAVILKPSEVSGHMADL-LATLIPQYMDQNLYLVVKGGVPETTELLKER 180 +V A+ AGN V+ KPSE++ +A+L L I + + +V+GG L R Sbjct: 157 NGHIVPALLAGNCVVFKPSELTPKVAELTLKAWIQAGLPAGVLNLVQGGRETGVALAAHR 216 Query: 181 -FDHIMYTGSTAVGKIVMAA-AAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFM 238 D + +TGS+ G ++ + + + LE+GG +P V++ DLD A I F+ Sbjct: 217 GLDGLFFTGSSRTGNLLHSQFGGQPQKILALEMGGNNPLVVEEVADLDAAVYTIIQSAFI 276 Query: 239 NSGQTCVAPDYILCDPSIQ-NQIVEKLKKSLKDFYGE--DAKQSRDYGRIINDRHFQRVK 295 ++GQ C +L + ++ +L D + + G +I+ + + Sbjct: 277 SAGQRCTCARRLLVPQGAWGDALLARLVAVSATLRVGRFDEQPAPFMGAVISLSAAEHLL 336 Query: 296 GLIDN------QKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLE 349 ++ Q + + + P IL DV + EE FGP++ ++ Sbjct: 337 KAQEHLIGKGAQPLLAMTQPIDGAALLTPGIL-DVSAVAERPDEEFFGPLLQVIRYSDFA 395 Query: 350 EAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSG 409 AI+ N + LA + S++ + ++ + E+ +G V N + + PFGG+G SG Sbjct: 396 AAIREANATQYGLAAGLLSDSRERFEQFLVESRAGIVNWNKQLTGA-ASSAPFGGIGASG 454 Query: 410 MGA 412 Sbjct: 455 NHR 457 >4KNA-A nrPDB Length = 495 Score = 354 bits (908), Expect = 6e-98, Method: Composition-based stats. Identities = 97/425 (22%), Positives = 169/425 (39%), Gaps = 23/425 (5%) Query: 2 SSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 + V AR AF + L R ++ ++ E ++++ + + GK W + Sbjct: 46 DDVERAVASARRAFAAWSALDLDARCTIVKRFAALLVERKEALATMIGRETGKPLWEAR- 104 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLT 121 EVA + ++D +I + ++ + P GVV V G +N+P +L Sbjct: 105 TEVASMAAKVDISITAYHERTGEKRA----PMADGVAVLRHRPHGVVAVFGPYNFPGHLP 160 Query: 122 IQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELLKER 180 +V A+ AGN V+ KPSE++ +A + + + +V+G L R Sbjct: 161 NGHIVPALIAGNTVVFKPSELAPGVARATVEIWRDAGLPAGVLNLVQGEKDTGVALANHR 220 Query: 181 -FDHIMYTGSTAVGKIVMAA-AAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFM 238 D + +TGS+ G ++ + + LE+GG +P V + D+D A F+ Sbjct: 221 QIDGLFFTGSSDTGTLLHKQFGGRPEIVLALEMGGNNPLVVAEVEDIDAAVHHAIQSAFL 280 Query: 239 NSGQTCVAPDYILCDPSIQ-NQIVEKLKKSLKDFYGE--DAKQSRDYGRIINDRHFQRVK 295 ++GQ C IL ++ V +L DA G +I+ R R+ Sbjct: 281 SAGQRCTCARRILVPRGAFGDRFVARLADVASKITASVFDADPQPFMGAVISARAASRLV 340 Query: 296 GLIDNQKVAHGG--------TWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRS 347 ++ G D + ++ IL DV + EE FGP+ IV Sbjct: 341 AA--QARLVGLGASPIIEMKQRDPALGFVNAAIL-DVTNVRELPDEEHFGPLAQIVRYTD 397 Query: 348 LEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGN 407 L++AI N L+ + +++E+ +G V N + PFGG G Sbjct: 398 LDDAIARANDTAFGLSAGLLADDEQAWHTFRRAIRAGIVNWNR-PTNGASSAAPFGGAGR 456 Query: 408 SGMGA 412 SG Sbjct: 457 SGNHR 461 >4H7N-A nrPDB Length = 474 Score = 351 bits (902), Expect = 3e-97, Method: Composition-based stats. Identities = 115/455 (25%), Positives = 212/455 (46%), Gaps = 33/455 (7%) Query: 4 ISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEE 63 ++ RAR A + + ++ RI L+ ++ I + ++ AL +D G+ Sbjct: 30 LAQQCNRARRAQSRWQELGVEGRITTLQQWKQAILSRREQLTEALVNDTGR--------- 80 Query: 64 VAHVLEELDTTIKELPDWAEDEP-VAKTRQTQQDDLYIHSE----PLGVVLVIGAWNYPF 118 ++ + E+D+ + + W P + +T +I + P +V VI WN+P Sbjct: 81 LSITVLEIDSFLASIDRWCGLAPELLQTSAKNTSIPFIALQQSLVPYPLVGVISPWNFPL 140 Query: 119 NLTIQPMVGAVAAGNAVILKPSEVSG-HMADLLATLIPQYMDQNLYLVVKGGVPETTELL 177 L++ + A+ AG AV++KPSE++ +A LL L +++ + V+GG ET L Sbjct: 141 TLSMIDTIPALLAGCAVVVKPSEIAPRFVAPLLMALNTVPELRDVLIFVEGGG-ETGANL 199 Query: 178 KERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKF 237 D + +TGS A G+ V AA+ P LELGGK P V + +L++A I WG Sbjct: 200 INYVDFVCFTGSVATGREVAETAARRFIPAYLELGGKDPAIVLESANLELATSAILWGAV 259 Query: 238 MNSGQTCVAPDYILCDPSIQNQIVEKL-KKSLKDFYGEDAKQSRDYGRIINDRHF----Q 292 +N+GQ+C++ + I S + +L K+ + + G II ++ Sbjct: 260 VNTGQSCLSIERIYVAESKFEEFYHQLIAKAHRLQLAYPLVEDGAIGPIIAEKQAGIIND 319 Query: 293 RVKGLIDNQKVA-HGGTWDQ--SSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLE 349 + ++ V GG ++ + PT++ +V+ VM EE FGP+MP++ +E Sbjct: 320 HILDAVEKGAVIHCGGKVEELGGGWWCRPTVMTNVNHSMKVMTEETFGPIMPVMPFPDVE 379 Query: 350 EAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPT-----LPFGG 404 EA+ N L+ VF+ +E K+ + ++G ++ ND + + F G Sbjct: 380 EAVYLANDTIYGLSAAVFAGSEDEALKVARQLNAGAISINDAALTAMMHEGEKNAFNFSG 439 Query: 405 VGNSGMGAYHGKKSFETFSHRRSCLVKSLLNEEAH 439 +G S +GA + F +++ L+K+ + Sbjct: 440 LGGSRVGA----AGLKRFLRKQAFLIKTNSTSDPW 470 >6DBB-A nrPDB Length = 511 Score = 348 bits (893), Expect = 3e-96, Method: Composition-based stats. Identities = 85/454 (18%), Positives = 182/454 (40%), Gaps = 31/454 (6%) Query: 2 SSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 + + A +AF +T R + + ++ E+ + + + GK Sbjct: 50 ADAERKIDAAHDAFLKWRTVPAPVRGELVRVFGNVLREHKAELGRLVTLEAGKITSEGL- 108 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLT 121 EV +++ D + ++ + + + P+GV VI A+N+P + Sbjct: 109 GEVQEMIDICDFAVGLSRQLYGLTIASERPGHRMMETW---HPIGVCGVISAFNFPVAVW 165 Query: 122 IQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYM-----------DQNLYLVVKGGV 170 A G++V+ KPSE + A L+ + + L +V G + Sbjct: 166 AWNAALAFVCGDSVVWKPSEKTPLTAIACHVLLQKALREFEKTHPGVAPAELGQLVLG-M 224 Query: 171 PETTELL--KERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVA 228 + E+L ++ + TGS +G+ V ++ L LELGG + V DLD+ Sbjct: 225 RDVGEVLTASKKVPVVSATGSVRMGQEVAKVLSQRLARGILELGGNNGMIVAPSADLDLV 284 Query: 229 CRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRIIN 287 R + + +GQ C ++ S+ Q++ +++K+ G ++ G +++ Sbjct: 285 VRAVTFAAVGTAGQRCTTLRRLIVHRSLVEQLLPRIEKAYASVKVGNPLEEGTLVGPLVD 344 Query: 288 DRHFQRVKGLIDNQK----VAHGGTWDQSS----RYIAPTILVDVDPQSPVMQEEIFGPV 339 F ++ + + + GG Y+ P I+ + QS V++ E F P+ Sbjct: 345 RASFDAMQKALADAREQGGEVKGGERVDVGHADAYYVRPAIV-RMPKQSAVVERETFAPI 403 Query: 340 MPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAET--SSGGVTANDVIVHITV 397 + ++ + ++AI N + L+ +F+N+ + ++ ++ G V N + Sbjct: 404 LYVMVYDNFDDAIDVHNAVPQGLSSAIFTNDMREAEQFMSAAGSDCGIVNVNIGTSGAEI 463 Query: 398 PTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVK 431 FGG +G G G +++ + R + + Sbjct: 464 GG-AFGGEKETGGGRESGSDAWKAYMRRATNTIN 496 >1UXV-A nrPDB Length = 501 Score = 345 bits (886), Expect = 2e-95, Method: Composition-based stats. Identities = 110/455 (24%), Positives = 192/455 (42%), Gaps = 29/455 (6%) Query: 1 MSSISDTVKRARE--------AFNSGKT----RSLQFRIQQLEALQRMINENLKSISGAL 48 +++I+ + +RE F G+ R+ L +I NL + L Sbjct: 42 LATIAKVISPSREEVERTLDVLFKRGRWSARDMPGTERLAVLRKAADIIERNLDVFAEVL 101 Query: 49 ASDLGKNEWTSYYEEVAHVLEELDTTIKELPDWAEDEPVAK-TRQTQQDDLYIHSEPLGV 107 + GK + + EV ++ L +L D T T + + + EPLGV Sbjct: 102 VMNAGKPKS-AAVGEVKAAVDRLRLAELDLKKIGGDYIPGDWTYDTLETEGLVRREPLGV 160 Query: 108 VLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLAT-LIPQYMDQNLYLVV 166 V I +NYP + + + GNAV++KPS A + L+ + ++ Sbjct: 161 VAAITPFNYPLFDAVNKITYSFIYGNAVVVKPSISDPLPAAMAVKALLDAGFPPDAIALL 220 Query: 167 KGGVPETTELL-KERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDL 225 E +++ +R + +TGST VG+ V+ + +ELGG P V +D DL Sbjct: 221 NLPGKEAEKIVADDRVAAVSFTGSTEVGERVVKVGG--VKQYVMELGGGDPAIVLEDADL 278 Query: 226 DVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGR 284 D+A +IA G + +GQ C A +L + + ++VE++ K L G+ + D G Sbjct: 279 DLAADKIARGIYSYAGQRCDAIKLVLAERPVYGKLVEEVAKRLSSLRVGDPRDPTVDVGP 338 Query: 285 IINDRHFQRVKGLIDNQKVAHGGTWDQSSR-----YIAPTIL---VDVDPQSPVMQEEIF 336 +I+ + I++ V GG R Y+ PT++ D + + E+F Sbjct: 339 LISPSAVDEMMAAIEDA-VEKGGRVLAGGRRLGPTYVQPTLVEAPADRVKDMVLYKREVF 397 Query: 337 GPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHIT 396 PV V V+ L++AI+ N R L VF + I++ + G + ND+ H Sbjct: 398 APVALAVEVKDLDQAIELANGRPYGLDAAVFGRDVVKIRRAVRLLEVGAIYINDMPRH-G 456 Query: 397 VPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVK 431 + PFGG SG+ + E + ++ + Sbjct: 457 IGYYPFGGRKKSGVFREGIGYAVEAVTAYKTIVFN 491 >4I3V-A nrPDB Length = 488 Score = 342 bits (878), Expect = 2e-94, Method: Composition-based stats. Identities = 109/418 (26%), Positives = 189/418 (45%), Gaps = 21/418 (5%) Query: 25 FRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEELDTTIKE-LPDWAE 83 R + L A + + IS + +LG ++ S Y EV + + + D E Sbjct: 71 ERQKILLATAEALAARKEEISDVITLELGISKADSLY-EVGRAFDVFTLAGQMCIRDDGE 129 Query: 84 DEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVS 143 T + ++ EPL + I +N+P N+ + A+A N V++KP+E++ Sbjct: 130 IFSCDLTPHGKARKIFTMREPLTAISAITPFNHPLNMVAHKVAPAIATNNCVVVKPTELT 189 Query: 144 GHMADLLATLIPQY-MDQNLYLVVKGGVPETTELL--KERFDHIMYTGSTAVGKIVMAAA 200 A LLA ++ + + + VV G + + D + +TGS VGK++ A A Sbjct: 190 PMTALLLADILYEAGLPPEMLSVVTGWPADIGMEMITNPHVDLVTFTGSVPVGKLIAANA 249 Query: 201 AKHLTPVTLELGGKSPCYVDK---DCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQ 257 H LELGG P + D DL A G NSGQ C A ILC S+ Sbjct: 250 --HYKRQVLELGGNDPLIILNDLSDDDLARAADLAVAGATKNSGQRCTAVKRILCQESVA 307 Query: 258 NQIVEKLKKSLKDF-YGEDAKQSRDYGRIINDRHF----QRVK-GLIDNQKVAHGGTWDQ 311 ++ V + + K +G+ +S D G +I+++ +RV + + + + Sbjct: 308 DRFVPLVLERAKRLRFGDPMDRSTDLGTVIHEKAAALFEERVMRAAEEGADILY--HPGR 365 Query: 312 SSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEA-IQFINQREKPLALYVFSNN 370 S + P ++ V QS ++ EE FGP++PIV V ++A I N L+ V +N+ Sbjct: 366 SGALLPPIVVDRVPHQSDLVLEETFGPIIPIVRVPDDDDATITLSNSTAFGLSSGVCTND 425 Query: 371 EKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMG-AYHGKKSFETFSHRRS 427 + ++K IA G V +V + PFGG+ +SG G ++ ++F++ ++ Sbjct: 426 YRRMQKYIAGLKVGTVNIWEVP-GYRIEMSPFGGIKDSGNGYKEGVIEAMKSFTNVKT 482 >3V9H-A nrPDB Length = 566 Score = 324 bits (832), Expect = 4e-89, Method: Composition-based stats. Identities = 93/447 (20%), Positives = 175/447 (39%), Gaps = 33/447 (7%) Query: 4 ISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMIN--ENLKSISGALASDLGKNEWTSYY 61 ++ ++ A A + + R Q M++ + ++ + GK + Sbjct: 105 LNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQ-GKTVIQAEI 163 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLT 121 + A +++ K + +P+ + +Y E G V I +N+ Sbjct: 164 DAAAELIDFFRFNAKYAVELEGQQPI-SVPPSTNSTVYRGLE--GFVAAISPFNFTA--I 218 Query: 122 IQPMVGAVA-AGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELL-- 177 + GA A GN V+ KPS+ + + + ++ + + N+ V P + + Sbjct: 219 GGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPLFGDTVTS 278 Query: 178 KERFDHIMYTGSTAVGKIVMAAAAKHL------TPVTLELGGKSPCYVDKDCDLDVACRR 231 E I +TGS K + A++L + E GGK+ +V + D++ Sbjct: 279 SEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSG 338 Query: 232 IAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQ-SRDYGRIINDR 289 F GQ C A + S+ QI +L + G+ A+ + +I+ + Sbjct: 339 TLRSAFEYGGQKCSACARLYVPHSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAK 398 Query: 290 HFQRVKGLIDNQK------VAHGGTWDQS-SRYIAPTILVDVDPQSPVMQEEIFGPVMPI 342 F R+K +++ + + GG D S ++ P I+ DPQ P+M+EEIFGPV+ + Sbjct: 399 SFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEEIFGPVLSV 458 Query: 343 VCVRS--LEEAIQFINQ-REKPLALYVFSNNEKVIKKMIAETS--SGGVTANDVIVHITV 397 +E +Q ++ L VFS ++ V+++ +G ND V Sbjct: 459 YVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYINDKSTGSIV 518 Query: 398 PTLPFGGVGNSGMGAY-HGKKSFETFS 423 PFGG SG G ++ Sbjct: 519 GQQPFGGARASGTNDKPGGPHYILRWT 545 >4LGZ-A nrPDB Length = 563 Score = 324 bits (831), Expect = 5e-89, Method: Composition-based stats. Identities = 93/467 (19%), Positives = 183/467 (39%), Gaps = 36/467 (7%) Query: 4 ISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMIN--ENLKSISGALASDLGKNEWTSYY 61 ++ + A A + + R Q M++ + ++ + GK + Sbjct: 102 LNRAIDAALAARKEWDLKPMADRAQVFLKAADMLSGPRRAEVLAKTMVGQ-GKTVIQAEI 160 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLT 121 + A +++ K + ++P++ T ++ G V I +N+ Sbjct: 161 DAAAELIDFFRFNAKFAVELEGEQPISVPPSTNHT---VYRGLEGFVAAISPFNFTA--I 215 Query: 122 IQPMVGAVA-AGNAVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTELL-- 177 + GA A GN V+ KPS+ + + + ++ + + N+ V P + + Sbjct: 216 GGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPTFGDTVTS 275 Query: 178 KERFDHIMYTGSTAVGKIVMAAAAKHL------TPVTLELGGKSPCYVDKDCDLDVACRR 231 E I +TGS K + A++L + E GGK+ +V D+D Sbjct: 276 SEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGGKNFHFVHSSADVDSVVSG 335 Query: 232 IAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQ-SRDYGRIINDR 289 F GQ C A + S+ QI +L + G+ A+ + +I+ + Sbjct: 336 TLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVIDAK 395 Query: 290 HFQRVKGLIDNQK------VAHGGTWDQS-SRYIAPTILVDVDPQSPVMQEEIFGPVMPI 342 F R+K +++ + + GG ++S Y+ P I+ DPQ P+M+EEIFGPV+ + Sbjct: 396 AFARIKKWLEHARSSPSLSILAGGQCNESVGYYVEPCIIESKDPQEPIMKEEIFGPVLTV 455 Query: 343 VCVRSLE--EAIQFINQ-REKPLALYVFSNNEKVIKKMIAETS--SGGVTANDVIVHITV 397 + E ++ ++ L VF+ ++ ++++ +G ND V Sbjct: 456 YVYPDDKYRETLKLVDSTTSYGLTGAVFAQDKAIVQEATRMLRNAAGNFYINDKSTGSVV 515 Query: 398 PTLPFGGVGNSGMGAY-HGKKSFETFSHRRSCLVKSLLNEEAHKARY 443 PFGG SG G ++ + ++K ++ RY Sbjct: 516 GQQPFGGARASGTNDKPGGPHYILRWTSPQ--VIKET-HKPLGDWRY 559 >4OE4-A nrPDB Length = 580 Score = 305 bits (782), Expect = 3e-83, Method: Composition-based stats. Identities = 88/433 (20%), Positives = 157/433 (36%), Gaps = 39/433 (9%) Query: 18 GKTRSLQFRIQQLEALQRMINEN-LKSISGALASDLGKNEWTSYYEEVAHVLEELDTTIK 76 R +I+ + A GKN + + + + + + +K Sbjct: 115 WYNLPFYDRSAIFLKAADLISTKYRYDMLAATMLGQGKNVYQAEIDCITELSDFFRYYVK 174 Query: 77 ELPDWAEDEPVAKTRQTQQDDLYIHSEPL-GVVLVIGAWNYPFNLTIQPMVGAVAAGNAV 135 D +PV T Y PL G V + +N+ + + GN V Sbjct: 175 YASDLYAQQPVESADGTWNKAEY---RPLEGFVYAVSPFNF-TAIAANLIGAPALMGNTV 230 Query: 136 ILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETTE--LLKERFDHIMYTGSTAV 192 + KPS+ + LL T++ + + + + + G + T+ L + F + +TGST V Sbjct: 231 VWKPSQTAALSNYLLMTVLEEAGLPKGVINFIPGDPVQVTDQVLADKDFGALHFTGSTNV 290 Query: 193 GKIVM--------AAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTC 244 K + + + E GGK+ V ++ A G F GQ C Sbjct: 291 FKSLYGKIQSGVVEGKYRDYPRIIGETGGKNFHLVHPSANISHAVLSTIRGTFEFQGQKC 350 Query: 245 VAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSR----------DYGRIINDRHFQRV 294 A + S + + + L+ S G +I+++ F ++ Sbjct: 351 SAASRLYLPESKSEEFLSDMFGILQSQNVVPMNTSASPISGGNLRGFMGPVIHEQSFDKL 410 Query: 295 KGLIDNQK------VAHGGTWDQS-SRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRS 347 +I++ K + +GG +D+S ++ PT++ P P M E FGP++ + Sbjct: 411 VKVIEDAKKDPELEILYGGQYDKSQGWFVGPTVIKAKRPDHPYMSTEFFGPILTVYEYPD 470 Query: 348 LE--EAIQFI-NQREKPLALYVFSNNEKVIKKMIAET--SSGGVTANDVIVHITVPTLPF 402 E E I N + L +F+ + K I+ + S+G ND V F Sbjct: 471 TEFNEICDIIDNTSQYALTGAIFAKDRKAIEYADEKLKFSAGNFYINDKCTGAVVSQQWF 530 Query: 403 GGVGNSGMGAYHG 415 GG SG G Sbjct: 531 GGARMSGTDDKAG 543 >4IDS-A nrPDB Length = 563 Score = 274 bits (702), Expect = 4e-74, Method: Composition-based stats. Identities = 88/417 (21%), Positives = 149/417 (35%), Gaps = 29/417 (6%) Query: 16 NSGKTRSLQFRIQQLEALQRMINEN-LKSISGALASDLGKNEWTSYYEEVAHVLEELDTT 74 + R ++ + I+ A K+ + + + V +++ Sbjct: 113 SDWAALPFDERAAVFLRAADLLAGPWREKIAAATMLGQSKSVYQAEIDAVCELIDFWRFN 172 Query: 75 IKELPDWAEDEPVAKTRQTQQDDLYIHSEPL-GVVLVIGAWNYPFNLTIQPMVGAVAAGN 133 + E +P++ + I PL G V I +N+ P A+ GN Sbjct: 173 VAFARQILEQQPISGPGE----WNRIDYRPLDGFVYAITPFNFTSIAGNLPTAPAL-MGN 227 Query: 134 AVILKPSEVSGHMADLLATLIPQY-MDQNLYLVVKGGVPETT--ELLKERFDHIMYTGST 190 VI KPS A L L+ + + +V G + L R I +TGST Sbjct: 228 TVIWKPSITQTLAAYLTMQLLEAAGLPPGVINLVTGDGFAVSDVALADPRLAGIHFTGST 287 Query: 191 AVGKIVMAAAAKHLTP------VTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTC 244 A + ++ + E GGK DV + G F GQ C Sbjct: 288 ATFGHLWQWVGTNIGRYHSYPRLVGETGGKDFVVAHASARPDVLRTALIRGAFDYQGQKC 347 Query: 245 VAPDYILCDPSIQNQIVEK-LKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQK- 302 A S+ ++ ++ L K+ + YG+ S G +I+ R F + I+ K Sbjct: 348 SAVSRAFIAHSVWQRMGDELLAKAAELRYGDITDLSNYGGALIDQRAFVKNVDAIERAKG 407 Query: 303 -----VAHGGTWDQS-SRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSL--EEAIQF 354 VA GG +D S ++ PT+L+ DP E FGP++ + E+ + Sbjct: 408 AAAVTVAVGGEYDDSEGYFVRPTVLLSDDPTDESFVIEYFGPLLSVHVYPDERYEQILDV 467 Query: 355 INQ-REKPLALYVFSNNEKVIKKMIAETS--SGGVTANDVIVHITVPTLPFGGVGNS 408 I+ L V +++ + + + +G ND V PFGG S Sbjct: 468 IDTGSRYALTGAVIADDRQAVLTALDRLRFAAGNFYVNDKPTGAVVGRQPFGGARGS 524 >5DBV-A nrPDB Length = 445 Score = 247 bits (631), Expect = 8e-66, Method: Composition-based stats. Identities = 78/449 (17%), Positives = 164/449 (36%), Gaps = 38/449 (8%) Query: 2 SSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 ++ ++ A+EA K S+ R + + A+++ E+ ++++ + G Sbjct: 16 DDMNQAIEAAKEAQLVVKKMSMDQREKIISAIRKKTIEHAETLARMAVEETG-------M 68 Query: 62 EEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLT 121 V H + + ++ P ++ + + P GV+ I P Sbjct: 69 GNVGHKILKHQLVAEKTPG--TEDITTTAWSGDRGLTLVEMGPFGVIGAITPCTNPSETI 126 Query: 122 IQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYM-----DQNLYLVVKGGVPETTEL 176 I +G +A GN V+ P + ++ LI + N+ V+ +++++ Sbjct: 127 ICNTIGMLAGGNTVVFNPHPAAIKTSNFAVQLINEASLSAGGPVNIACSVRKPTLDSSKI 186 Query: 177 LKERFD--HIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAW 234 + D I TG V V+ + G P VD+ D+ A I Sbjct: 187 MMSHQDIPLIAATGGPGVVTAVLQSG----KRGIGAGAGNPPVLVDETADIRKAAEDIIN 242 Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRV 294 G ++ +A ++ +I N+++ + K + +Q + +I + R Sbjct: 243 GCTFDNNLPAIAEKEVVAIDAIANELMNYMVKEQGCYAITKEQQEKLTNLVITPKGLNRN 302 Query: 295 KGLIDNQKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQF 354 D + + D S I+ + + + P++ EE+ P++ IV +S ++A++ Sbjct: 303 CVGKDARTLLGMIGIDVPSNI--RCIIFEGEKEHPLISEELMMPILGIVRAKSFDDAVEK 360 Query: 355 INQREKP--LALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGA 412 E + ++ S N I + + N P+ G G G Sbjct: 361 AVWLEHGNRHSAHIHSKNVDRITTYAKAIDTAILVKN-------APSYAAIGFGGEGFCT 413 Query: 413 Y-------HGKKSFETFSHRRSCLVKSLL 434 + G S TF+ RR C++ L Sbjct: 414 FTIASRTGEGLTSASTFTKRRRCVMSDSL 442 >1O20-A nrPDB Length = 427 Score = 212 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 83/462 (17%), Positives = 168/462 (36%), Gaps = 80/462 (17%) Query: 1 MSSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 M + + K+ REA++ + + + + + ++ + ++E K I A D+ K Sbjct: 13 MDELLEKAKKVREAWDVLRNATTREKNKAIKKIAEKLDERRKEILEANRIDVEKARERGV 72 Query: 61 YEEVAHVLEELDTTIKELPDWAE-----DEPVAKTRQT--QQDDLYI--HSEPLGVVLVI 111 E + L D I E+ E +PV + + ++D L I P+G + +I Sbjct: 73 KESLVDRLALNDKRIDEMIKACETVIGLKDPVGEVIDSWVREDGLRIARVRVPIGPIGII 132 Query: 112 GAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYM---------DQNL 162 + N+T++ + A+ +GN ++L+ + + + + I + + + + Sbjct: 133 --YESRPNVTVETTILALKSGNTILLRGGSDALNSNKAIVSAIREALKETEIPESSVEFI 190 Query: 163 YLVVKGGVPETTELLKERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELG-GKSPCYVDK 221 + V E L+E ++ G + V A + LE G G +VD+ Sbjct: 191 ENTDRSLVLEMIR-LREYLSLVIPRGGYGLISFVRDNATVPV----LETGVGNCHIFVDE 245 Query: 222 DCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRD 281 DL A I K G TC A + +L I + + + + L+ Sbjct: 246 SADLKKAVPVIINAKTQRPG-TCNAAEKLLVHEKIAKEFLPVIVEELR------------ 292 Query: 282 YGRIINDRHFQRVKGLIDNQKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMP 341 +H V+G + +R I P ++ + P E ++ Sbjct: 293 -------KHGVEVRGC-------------EKTREIVPDVVPATEDDWP---TEYLDLIIA 329 Query: 342 IVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLP 401 I V++++EAI+ I + + + + N KK ++E + V N + Sbjct: 330 IKVVKNVDEAIEHIKKYSTGHSESILTENYSNAKKFVSEIDAAAVYVN--------ASTR 381 Query: 402 FGGVGNSGMGAYH----------GKKSFETFSHRRSCLVKSL 433 F G G GA G + + ++ Sbjct: 382 FTDGGQFGFGAEIGISTQRFHARGPVGLRELTTYKFVVLGEY 423 >5J7I-A nrPDB Length = 488 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 76/419 (18%), Positives = 162/419 (38%), Gaps = 30/419 (7%) Query: 1 MSSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 + + + ++ A+ A + + + +E++ E ++ + G + Sbjct: 33 IQEVRNYLEEAKAAQKILEKMTQSEIDKIVESMANAAREEAGRLAAMAVEETG------F 86 Query: 61 YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNL 120 L+ L + + V R+ +++ ++ ++P+G+V I P + Sbjct: 87 GNVEDKTLKNLFAANDVYNSIKDVKTVGIIRRDEENRVWEIAQPVGIVAGIIPSTNPTST 146 Query: 121 TIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYM-----DQNLY-LVVKGGVPETT 174 I + AV A NA++ P + A ++ + + L + + + T Sbjct: 147 VIFKALIAVKARNAIVFSPHPSAAKCTAEAARIMQEAAERAGAPKGLISCITQPTMAATN 206 Query: 175 ELLKERF-DHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIA 233 EL+K + D I+ TG G ++ AA P G P Y+ + ++ A + I Sbjct: 207 ELMKHKLTDVILATG----GPGLVKAAYSSGKPAYGVGPGNVPVYIHESANIAKAVQLII 262 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQR 293 K + G C + +L D SI+ ++V +LK+ F E+ KQ ++N + Sbjct: 263 QSKTFDYGTICASEQALLVDESIKEKVVAELKQQGAYFLNEEEKQKVASIIMVNGSLNAK 322 Query: 294 VKGLIDNQKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQ 353 + G G S + +V + P E++ P++ V+ +EEA + Sbjct: 323 IVGKAPQVIAEMAGIEIPSDVKLLVAEETEVGKEYPFSIEKL-SPILAFYIVKGMEEASE 381 Query: 354 FINQREK----PLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNS 408 + + + + + +EKVI+ + +G + N FGG+G + Sbjct: 382 LAQKLLEVGGLGHTVGIHAEDEKVIEAYTIDKPAGRIVVNAGTT--------FGGIGAT 432 >5JFN-A nrPDB Length = 524 Score = 196 bits (499), Expect = 2e-50, Method: Composition-based stats. Identities = 88/444 (19%), Positives = 162/444 (36%), Gaps = 61/444 (13%) Query: 22 SLQFRIQQLEALQRMINEN--LKSISGALASDLG------KNEWTSYYEEVAHVLEELDT 73 S+ R + ++ ++ +I L+ +S + G K E +E D Sbjct: 112 SMSDRARFVQGIRDVILNQDTLEKMSRMAVEETGMGNYEHKLIKNRLAGEKTPGIE--DL 169 Query: 74 TIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGN 133 T + P GV+ I P + +G +AAGN Sbjct: 170 TTDAFSG-------------DNGLTLVEYSPFGVIGAITPTTNPTETIVCNSIGMLAAGN 216 Query: 134 AVILKPSEVSGHMADLLATLIPQYM-----DQNLYLVVKGGVPETTELLKER--FDHIMY 186 +V+ P + ++ LL LI Q + +NL + V+ E T + ++ Sbjct: 217 SVVFSPHPRARQVSLLLVRLINQKLAALGAPENLVVTVEKPSIENTNAMMAHPKVRMLVA 276 Query: 187 TGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVA 246 TG A+ K V++ G P VD+ +++ A I G ++ VA Sbjct: 277 TGGPAIVKAVLSTG----KKAIGAGAGNPPVVVDETANIEKAACDIVNGCSFDNNLPXVA 332 Query: 247 PDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQKVAHG 306 I+ I + ++ LKK+ + A + ++ + G + V Sbjct: 333 EKEIIAVAQIADYLIFNLKKNGAYEIKDPAVLQQLQDLVLTAK------GGPQTKCVGKS 386 Query: 307 GTWDQSSRYIA-----PTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKP 361 W S I+ IL++V + P +QEE+ P++P+V V ++++AI + E Sbjct: 387 AVWLLSQIGISVDASIKIILMEVPREHPFVQEELMMPILPLVRVETVDDAIDLAIEVEHD 446 Query: 362 --LALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAY------ 413 + S + + + KM + N P+ G G G + Sbjct: 447 NRHTAIMHSTDVRKLTKMAKLIQTTIFVKNG-------PSYAGLGAGGEGYSTFTIAGPT 499 Query: 414 -HGKKSFETFSHRRSCLVKSLLNE 436 G S ++F+ RR C++ LN Sbjct: 500 GEGLTSAKSFARRRKCVMVEALNI 523 >5UJU-A nrPDB Length = 576 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 87/444 (19%), Positives = 151/444 (34%), Gaps = 45/444 (10%) Query: 5 SDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEV 64 + A A + + I + +N I+ ++ G+ ++ Sbjct: 98 DALIAAAAAAQRTWREAGPSAWIGVSLEILARLNRASFEIAYSVMHTTGQAFMMAFQAGG 157 Query: 65 AHVLEELDTTIKEL--------PDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNY 116 H + + D ++P K Y P G LV+G + Sbjct: 158 PHAQDRALEAVAYAWDQLRRIPADAHWEKPQGKNPPLAMQKRYTI-VPRGTGLVLGCCTF 216 Query: 117 PFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLI-----PQYMDQNLYLVV----K 167 P + +A GN VI+KP + + + D N+ ++ Sbjct: 217 PTWNGYPGLFADLATGNTVIVKPHPGAILPLAITVRIARDVLREAGFDPNVVTLLATEPN 276 Query: 168 GGVPETTELLKERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDV 227 G L+ I +TGST G + A H V E G + +D DL Sbjct: 277 DGALVQDLALRPEIKLIDFTGSTQNGTWLERHA--HQAQVYTEKAGVNQIVIDSTDDLKA 334 Query: 228 ACRRIAWGKFMNSGQTCVAPDYILCDP---------SIQNQIVEKLKKSLKDFYGEDAKQ 278 A + IA+ + SGQ C AP I + +++ + + +++ G+ A+ Sbjct: 335 AAKNIAFSLALYSGQMCTAPQNIYVPRDGIRTADGHASFDEVAQAIAGAVQKLTGDPARS 394 Query: 279 SRDYGRIINDRHFQRVKG-------LIDNQKVAHGGTWDQSSRYIAPTIL-VDVDPQSPV 330 G I ND R+ L+D+Q + H D +R P +L +DV + Sbjct: 395 VELIGAIQNDGVTARIDAARAVGRVLLDSQTLQHPAFPD--ARVRTPLVLQLDVADREKF 452 Query: 331 MQEEIFGPVMPIVCVRSLEEAIQFI---NQREKPLALYVFSNNEKVIKKMIAETSSGGV- 386 Q E FGP+ ++ S +++ L L V+S + VI GGV Sbjct: 453 TQ-EWFGPISFVIATDSTAQSLDLAGEIAAEHGALTLSVYSTADDVIDAAHEAAVRGGVA 511 Query: 387 -TANDVIVHITVPTLPFGGVGNSG 409 + N + F +G Sbjct: 512 LSINLTGGVFVNQSAAFSDFHGTG 535 >3V4C-A nrPDB Length = 528 Score = 166 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 75/430 (17%), Positives = 147/430 (34%), Gaps = 36/430 (8%) Query: 4 ISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEE 63 ++ + A EAF + S + R L A+ I ++I+ + + G E E Sbjct: 65 VNRACEAAEEAFWTYGYSSRKERAAFLRAIADEIEARAEAITEIGSQETGLPEAR-LNGE 123 Query: 64 VAHVLEELDTTIKE-----LPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPF 118 +L D D + + + + ++ + P+G V V GA N+P Sbjct: 124 RGRTTGQLRLFADHIEKGDYLDRRVDAAMPERQPAPRQEIRLVQRPVGPVAVFGASNFPL 183 Query: 119 N--LTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQY-----MDQNLYLVVKGGVP 171 A+AAG V++K +++A + + ++ +++GG Sbjct: 184 AFSTAGGDTAAALAAGCPVVVKGHSAHPGTGEIVAEAVDAAIRKTGVHPGVFSLIQGGSR 243 Query: 172 ETTELL--KERFDHIMYTGSTAVGKIVMAAAAKHLTPV--TLELGGKSPCYVDKDCDLDV 227 + L + +TGS A G+ + A P+ ELG +P ++ + L Sbjct: 244 DVGHALVQHPHIKAVGFTGSLAGGRALFDLCAARPEPIPFFGELGSVNPMFLLPEA-LKA 302 Query: 228 ACRRI----AWGKFMNSGQTCVAPDYILCDPSI-QNQIVEKLKKSLKDFYGEDAKQSRDY 282 + A M +GQ C P + ++ ++L Sbjct: 303 RAETLGQGWAGSLTMGAGQFCTNPGIAVVIEGADADRFTTAAVEALAKV-----APQTML 357 Query: 283 GRIINDRHFQRVKGLIDNQKVAHGGTWDQSSRYIAPTILVDVDPQ---SPVMQEEIFGPV 339 I + V + S R +P + Q + EE+FGP+ Sbjct: 358 TDGIAKAYRDGQARFATRNAVKPLLATESSGRDASPNLFETTGAQFLADHALGEEVFGPL 417 Query: 340 MPIVCVRSLEEAIQFINQREKPLALYVF--SNNEKVIKKMIAETS--SGGVTANDVIVHI 395 +V V S E + + L + + + + +++ +G V N + Sbjct: 418 GLVVRVGSPAEMEELARGFQGQLTATIHMDAGDLETARRLRPVLERKAGRVLVNGFPTGV 477 Query: 396 -TVPTLPFGG 404 V ++ GG Sbjct: 478 EVVDSMVHGG 487 >3MY7-A nrPDB Length = 452 Score = 155 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 53/415 (12%), Positives = 131/415 (31%), Gaps = 26/415 (6%) Query: 1 MSSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 M+ + + R ++A T S + + A N+ ++ + G Sbjct: 6 MAELDAMIARVKKAQEEFATYSQEQVDKIFRAASLAANQARIPLAQQAVEESGMGIVEDK 65 Query: 61 YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNL 120 + E + + +++ + +EP+G++ I P + Sbjct: 66 VIKNHFASEFI------YNKYKDEQTCGILEEDDNLGTMTIAEPVGIICGIVPTTNPTST 119 Query: 121 TIQPMVGAVAAGNAVILKPSEVSGHMADLLATLI-----PQYMDQNLYLVVKGGVPETTE 175 I + ++ N +I P + + + A L+ +++ + E + Sbjct: 120 AIFKSLISLKTRNGIIFSPHPRAKNSTNDAAKLVLDAAVAAGAPKDIIGWIDQPSVELSN 179 Query: 176 LLKER--FDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIA 233 L + I+ TG G ++ AA P G P +D+ D+ A + Sbjct: 180 ALMKHDDIALILATG----GPGMVKAAYSSGKPAIGVGAGNVPVVIDETADIKRAVASVL 235 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQR 293 K ++G C + ++ + +++ E+ + +I+ + Sbjct: 236 MSKTFDNGVVCASEQAVIVVDEVYDEVKERFASHKAHVLSKTDADKVRKVLLIDGALNAK 295 Query: 294 VKGLIDNQKVAHGG-TWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAI 352 + G G ++ + L V E++ P + + + E+A+ Sbjct: 296 IVGQPATAIAEMAGVKVPADTKVLIGEGLGKVSYDDAFAHEKL-SPTLGMFRADNFEDAV 354 Query: 353 QFINQREK----PLALYVFSN---NEKVIKKMIAETSSGGVTANDVIVHITVPTL 400 + +++N N I+ + + + N H + L Sbjct: 355 AQAVTMVEIGGIGHTSGLYTNQDVNADRIRYFGDKMKTARILINIPTTHGGIGDL 409 >3K9D-A nrPDB Length = 464 Score = 147 bits (372), Expect = 9e-36, Method: Composition-based stats. Identities = 56/411 (13%), Positives = 142/411 (34%), Gaps = 41/411 (9%) Query: 1 MSSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 + + + ++ A +A S Q ++A+ + ++ + G W Sbjct: 11 IQEVRNLIESANKAQKELAAMSQQQIDTIVKAIADAGYGAREKLAKMAHEETGFGIWQDK 70 Query: 61 YEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNL 120 + + + IK++ + + ++ + + + PLGVV + P + Sbjct: 71 VIKNVFASKHVYNYIKDM------KTIGMLKEDNEKKVMEVAVPLGVVAGLIPSTNPTST 124 Query: 121 TIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYM-----DQNLYLVVKGGVPETTE 175 I + ++ AGN+++ P + +I + + + + T+ Sbjct: 125 VIYKTLISIKAGNSIVFSPHPNALKAILETVRIISEAAEKAGCPKGAISCMTVPTIQGTD 184 Query: 176 LLKERFD--HIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIA 233 L + D I+ TG G ++ AA TP G P ++++ ++ A + I Sbjct: 185 QLMKHKDTAVILATG----GSAMVKAAYSSGTPAIGVGPGNGPAFIERSANIPRAVKHIL 240 Query: 234 WGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGE---------DAKQSRDYGR 284 K ++G C + ++ + + ++ + +K F + + + Sbjct: 241 DSKTFDNGTICASEQSVVVERVNKEAVIAEFRKQGAHFLSDAEAVQLGKFILRPNGSMNP 300 Query: 285 IINDRHFQRVKGLIDNQKVAHGGTWDQSSRYIAPTILVDVDPQSPV-MQEEIFGPVMPIV 343 I + Q + L G T +R + I + + + E P++ Sbjct: 301 AIVGKSVQHIANL-------AGLTVPADARVL---IAEETKVGAKIPYSREKLAPILAFY 350 Query: 344 CVRSLEEAIQFINQREK----PLALYVFSNNEKVIKKMIAETSSGGVTAND 390 + +EA + L + S ++++I++ + + N Sbjct: 351 TAETWQEACELSMDILYHEGAGHTLIIHSEDKEIIREFALKKPVSRLLVNT 401 >2Y53-A nrPDB Length = 534 Score = 143 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 63/416 (15%), Positives = 150/416 (36%), Gaps = 38/416 (9%) Query: 3 SISDTVKRARE-AFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYY 61 ++ ARE + + + R +L + +++ ++ G S Sbjct: 44 DLARAFSFAREDGGAALRALTYAQRAARLADIVKLLQAKRGDYYAIATANSGTTRNDSAV 103 Query: 62 EEVAHVL-----EELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNY 116 + + +L ++ E+ + + ++ ++ S GV L I A+N+ Sbjct: 104 DIDGGIFTLSYYAKLGASLGEVHALRDGSAESLSKDRSFSAQHVLSPTRGVALFINAFNF 163 Query: 117 PFNLTIQPMVGAVAAGNAVILKPSEVSG-HMADLLATLIPQY-MDQNLYLVVKGGVPETT 174 P + A+ +G VI+KP+ + ++A ++ + ++ G Sbjct: 164 PSWGLWEKAAPALLSGVPVIVKPATATAWLTQRMVADVVDAGILPPGALSIICGSSAGLL 223 Query: 175 ELLKERFDHIMYTGSTAVGKIVMAAAA--KHLTPVTLELGGKSPCYVDKDC--D---LDV 227 + ++ FD + +TGS + A A + + ++ + + D D D+ Sbjct: 224 DQIRS-FDVVSFTGSADTAATLRAHPAFVQRGARLNVQADSLNSAILCADATPDTPAFDL 282 Query: 228 ACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDF-YGEDAKQSRDYGRII 286 + + + SGQ C A + ++E LK L G + G ++ Sbjct: 283 FIKEVVREMTVKSGQKCTAIRRAFVPEAALEPVLEALKAKLAKITVGNPRNDAVRMGSLV 342 Query: 287 NDRHFQRVKGLI----DNQKVAH---GGTWDQSSRYIAPTI-----LVDVDPQSPVMQE- 333 + ++ V I + +A+ + IA + +V+ + ++ + Sbjct: 343 SREQYENVLAGIAALREEAVLAYDSSAVPLIDADANIAACVAPHLFVVNDPDNATLLHDV 402 Query: 334 EIFGPVMPIVCVR--------SLEEAIQFINQREKPLALYVFSNNEKVIKKMIAET 381 E+FGPV + R A+ + + L ++SN++ + ++ E Sbjct: 403 EVFGPVASVAPYRVTTDTNALPEAHAVALARRGQGSLVASIYSNDDAHLGRLALEL 458 >1EZ0-A nrPDB Length = 510 Score = 141 bits (355), Expect = 9e-34, Method: Composition-based stats. Identities = 67/411 (16%), Positives = 135/411 (32%), Gaps = 30/411 (7%) Query: 19 KTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEELDTTIKEL 78 + + R L + + I + E E+A +L + Sbjct: 47 RRLNNSKRASLLRTIASELEARSDDIIARAHLETALPEVR-LTGEIARTANQLRLFADVV 105 Query: 79 PDWAEDEPVAKTR-----QTQQDDLYIHSEPLGVVLVIGAWNYPFNLTI--QPMVGAVAA 131 + + + T + D+ LG V V GA N+P + A+AA Sbjct: 106 NSGSYHQAILDTPNPTRAPLPKPDIRRQQIALGPVAVFGASNFPLAFSAAGGDTASALAA 165 Query: 132 GNAVILKPSEVSGHMADLLATLIPQY-----MDQNLYLVVKGGVPETTELLKER--FDHI 184 G VI+K + ++A I Q + Q ++ +++G + L + Sbjct: 166 GCPVIVKGHTAHPGTSQIVAECIEQALKQEQLPQAIFTLLQGNQRALGQALVSHPEIKAV 225 Query: 185 MYTGSTAVGKIVMAAAAKHLTPV--TLELGGKSPCYVDKDCDLDVA--CRRIAWGKFMNS 240 +TGS G+ + A + P+ ELG +P ++ A + M Sbjct: 226 GFTGSVGGGRALFNLAHERPEPIPFYGELGAINPTFIFPSAMRAKADLADQFVASMTMGC 285 Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDN 300 GQ C P + ++ + ++ + S I D + +V + Sbjct: 286 GQFCTKPGVVF---ALNTPETQAFIETAQSLI-RQQSPSTLLTPGIRDSYQSQVVSRGSD 341 Query: 301 QKVAHGGTWDQSSRYIAPTILVDVD--PQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQR 358 + + +S + + + + P +EEIFGP IV ++ + + Sbjct: 342 DGIDVTFSQAESPCVASALFVTSSENWRKHPAWEEEIFGPQSLIVVCENVADMLSLSEML 401 Query: 359 EKPLALYVFS--NNEKVIKKMIAETS--SGGVTANDVIVHITVPTLP-FGG 404 L + + + + ++I +G + N + V GG Sbjct: 402 AGSLTATIHATEEDYPQVSQLIPRLEEIAGRLVFNGWPTGVEVGYAMVHGG 452 >6D97-A nrPDB Length = 547 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 75/401 (18%), Positives = 142/401 (35%), Gaps = 46/401 (11%) Query: 44 ISGALASDLGKNEWTSYYEEVAHVLEELD-TTIKELPDWAEDEPVAKTRQTQQDDLYIHS 102 + + K+ + EV + L+ ++ A V Q+ + Y Sbjct: 130 FAKLIQRVSPKSYQQAL-AEVQVSQKFLENFCGDQVRFLARSFAVPGNHLGQRSNGY--R 186 Query: 103 EPLGVVLVIGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQ-YMDQN 161 P G V +I +N+P + + ++GA+ GN +LK + + + L+ + Sbjct: 187 WPYGPVAIITPFNFPLEIPLLQLMGALYMGNKPVLKVDSKVSIVMEQMIRLLHDCGLPAE 246 Query: 162 LYLVVKGGVPETTELLKE-RFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVD 220 + +LL E ++TGS+ V + + AA V LE G + Sbjct: 247 DMDFINSDGAVMNKLLLEANPKMTLFTGSSRVAEKL---AADLKGRVKLEDAGFDWKILG 303 Query: 221 KDC-DLDVACRRIAWGKFMNSGQTCVAPDYILCDPS-IQNQIVEKLKKSLKDFYGEDAKQ 278 D ++D + SGQ C A + + + ++EK+KK + ED Sbjct: 304 PDVQEVDYVAWVCDQDAYACSGQKCSAQSVLFMHKNWSSSGLLEKMKKLSERRKLEDL-- 361 Query: 279 SRDYGRIIND------RHFQRVKGLIDNQKVAHGGT------WDQSSRYIAPT-ILVDVD 325 G ++ H + I KV GG + + PT + V ++ Sbjct: 362 --TIGPVLTVTTEAMIEHMNNLLK-IRGSKVLFGGEPLANHSIPKIYGAMKPTAVFVPLE 418 Query: 326 P-----QSPVMQEEIFGPVMPIVCVRSLE-----EAIQFINQREKPLALYVFSNNEKVIK 375 ++ +EIFGP + + EA + +N L + SN+ ++ Sbjct: 419 EILKSGNFELVTKEIFGPFQVVTEYSEDQLELVLEACERMNAH---LTAAIVSNDPLFLQ 475 Query: 376 KMIAETSSGGVTANDVIVHITVPT----LPFGGVGNSGMGA 412 ++ + +G A P P G +G+G Sbjct: 476 DVLGRSVNGTTYAGIRARTTGAPQNHWFGPAGDPRGAGIGT 516 >4GHK-A nrPDB Length = 444 Score = 117 bits (294), Expect = 9e-27, Method: Composition-based stats. Identities = 78/437 (17%), Positives = 137/437 (31%), Gaps = 75/437 (17%) Query: 23 LQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEELDTTIKELPDWA 82 + LEA+ R I + ++ A A D+ + + L D +K + + Sbjct: 47 TAAKNAALEAVARAIERDAGALKAANARDVARAKDKGLDAAFVDRLTLSDKALKTMVEGL 106 Query: 83 EDEPVAKTRQTQQDDLYIH---------SEPLGVVLVIGAWNYPFNLTIQPMVGAVAAGN 133 + +L PLGV+ +I + N+TI + +GN Sbjct: 107 RQVATLPDPIGEMSNLKYRPSGIQVGQMRVPLGVIGII--YESRPNVTIDAAALCLKSGN 164 Query: 134 AVILKPSEVSGHMADLLATLIPQYM-----DQNLYLVV-KGGVPETTEL--LKERFDHIM 185 A IL+ + LA LI + + Q+ VV L + E D I+ Sbjct: 165 ATILRGGSEALESNTALAKLIGEGLAEAGLPQDTVQVVETADRAAVGRLITMTEYVDVIV 224 Query: 186 YTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCV 245 G ++ + ++ A P+ L G YVD + A K G TC Sbjct: 225 PRGGKSLIERLINEAR---VPMIKHLDGICHVYVDDRASVTKALTVCDNAKTHRYG-TCN 280 Query: 246 APDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQKVAH 305 + +L I ++ L GR+ ++ + + Sbjct: 281 TMETLLVARGIAPAVLSPL------------------GRLYREKGVELRVDADARAVLEA 322 Query: 306 GGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFINQREKP--LA 363 G LVD + + E PV+ I V ++ AI+ IN E Sbjct: 323 AGVGP----------LVDATDED--WRTEYLAPVLAIKIVDGIDAAIEHIN--EYGSHHT 368 Query: 364 LYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFGGVGNSGMGAYH--------- 414 + + + + + E S V N + F G+GA Sbjct: 369 DAIVTEDHDRAMRFLREVDSASVMVN--------ASTRFADGFEFGLGAEIGISNDKLHA 420 Query: 415 -GKKSFETFSHRRSCLV 430 G E + + ++ Sbjct: 421 RGPVGLEGLTSLKYVVL 437 >1VLU-A nrPDB Length = 468 Score = 106 bits (264), Expect = 3e-23, Method: Composition-based stats. Identities = 93/439 (21%), Positives = 158/439 (35%), Gaps = 62/439 (14%) Query: 1 MSSISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSY 60 MSS K AR+A N KT S + R L + + N +I A DL + T Sbjct: 13 MSSSQQIAKNARKAGNILKTISNEGRSDILYKIHDALKANAHAIEEANKIDLAVAKETGL 72 Query: 61 YEEVAHVLE-----ELDTTIKELPDWAE-DEPVAKTRQTQQ-DDLYIHSE---PLGVVLV 110 + + L+ + + ++ + D AE ++PV K + ++ DD + P+GV+LV Sbjct: 73 ADSLLKRLDLFKGDKFEVMLQGIKDVAELEDPVGKVKMARELDDGLTLYQVTAPVGVLLV 132 Query: 111 IGAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQ---------YMDQN 161 I + + ++ +GNA ILK + S + +A ++ + Sbjct: 133 I--FESRPEVIANITALSIKSGNAAILKGGKESVNTFREMAKIVNDTIAQFQSETGVPVG 190 Query: 162 LYLVVKGGVPETTELLK--ERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYV 219 +++ ++LL E D ++ GS A+ + + PV G Y+ Sbjct: 191 SVQLIETRQD-VSDLLDQDEYIDLVVPRGSNALVRKIKDTTK---IPVLGHADGICSIYL 246 Query: 220 DKDCDLDVACRRIAWGKFMN-SGQTCVAPDYILCDPSIQN--QIVEKLKKSLKDFYGEDA 276 D+D DL A R K +G C A + +L +P +++E L Sbjct: 247 DEDADLIKAKRISLDAKTNYPAG--CNAMETLLINPKFSKWWEVLENLTLEGGVTIHATK 304 Query: 277 KQSRDYGRIINDRHFQRVKGLIDNQKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIF 336 Y F ++ L K+ T+ D + +E Sbjct: 305 DLKTAY--------FDKLNEL---GKLTEAIQCK--------TVDADEEQD---FDKEFL 342 Query: 337 GPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHIT 396 + V S E AIQ IN + + N+ +K + S GV N Sbjct: 343 SLDLAAKFVTSTESAIQHINTHSSRHTDAIVTENKANAEKFMKGVDSSGVYWN------- 395 Query: 397 VPTLPFGGVGNSGMGAYHG 415 + F G GA G Sbjct: 396 -ASTRFADGFRYGFGAEVG 413 >2H5G-A nrPDB Length = 463 Score = 95.7 bits (237), Expect = 4e-20, Method: Composition-based stats. Identities = 74/432 (17%), Positives = 150/432 (34%), Gaps = 72/432 (16%) Query: 3 SISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYE 62 ++ + AR T + R + + L ++ + I A DL + E Sbjct: 30 TVEQQGEMARSGGRMLATLEPEQRAEIIHHLADLLTDQRDEILLANKKDLEEAEGRLAAP 89 Query: 63 EVAHV------LEELDTTIKELPDWAEDE---PVAKTRQTQQDDLYIHSEPLGVVLVIGA 113 + + L L ++++ ++D + +TR + +L + P+GV+LVI Sbjct: 90 LLKRLSLSTSKLNSLAIGLRQIAASSQDSVGRVLRRTRIAKNLELEQVTVPIGVLLVI-- 147 Query: 114 WNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYM-----DQNLYLVVKG 168 + + Q A+A+GN ++LK + + H +L L + + + + LV Sbjct: 148 FESRPDCLPQVAALAIASGNGLLLKGGKEAAHSNRILHLLTQEALSIHGVKEAVQLVNTR 207 Query: 169 GVPETTELLKERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCDLDVA 228 E L + D I+ GS+ + + + AA PV G YVD + +D Sbjct: 208 EEVEDLCRLDKMIDLIIPRGSSQLVRDIQKAAKG--IPVMGHSEGICHMYVDSEASVDKV 265 Query: 229 CRRIAWGKFMNSGQTCVAPDYILCDPS-----IQNQIVEKLKKSLKDFYGEDAKQSRDYG 283 R + K C A + +L + +QI++ L+ Sbjct: 266 TRLVRDSKCEYPA-ACNALETLLIHRDLLRTPLFDQIIDMLR------------------ 306 Query: 284 RIINDRHFQRVKGLIDNQKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIV 343 ++ K+ G + + + ++ E + I Sbjct: 307 --------------VEQVKIHAGPKFASYLTF--------SPSEVKSLRTEYGDLELCIE 344 Query: 344 CVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVIVHITVPTLPFG 403 V ++++AI I++ + + +E + + S V N + F Sbjct: 345 VVDNVQDAIDHIHKYGSSHTDVIVTEDENTAEFFLQHVDSACVFWN--------ASTRFS 396 Query: 404 GVGNSGMGAYHG 415 G+GA G Sbjct: 397 DGYRFGLGAEVG 408 >4JBE-A nrPDB Length = 445 Score = 93.8 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 60/408 (14%), Positives = 121/408 (29%), Gaps = 67/408 (16%) Query: 4 ISDTVKRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEE 63 + + + A+ A S LE++ + + ++ A A D+ K E Sbjct: 41 VEECARAAKSAAPSLSGAPDTAIDAALESMADRLLAHRDAVLAANAEDIAKAEAGGMSAG 100 Query: 64 VAHVLEELDTTIKELPDWAE--------DEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWN 115 + L ++ + ++ D V + L P+GV+ N Sbjct: 101 LLDRLTITESRLTDMADQLRLLAGAPHPQRTVELSTLDGGLRLVERRRPVGVIGA----N 156 Query: 116 Y--PFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLAT------LIPQYMDQNLYLVVK 167 Y N+T+ V + NA +L+ + A L L +D N+ +V Sbjct: 157 YEARPNVTVDVASQLVKSRNAGVLRTGSAALKSAQRLLEVVIRPALTDSGIDANVVQLVP 216 Query: 168 GGVPETTELLK---ERFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCYVDKDCD 224 E L + ++ GS + + AA+H G YVD+ D Sbjct: 217 RPEREAAGALVRLPDLVPLVILRGSGESTRALALEAAQHGVRTLAHADGGGVLYVDEKAD 276 Query: 225 LDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGR 284 D R + G C + +L ++ + + ++L + + D Sbjct: 277 RD-TVRSLVVNSLDRLG-VCNRLNLLLIHDAVYEEFWPVVSEALAERGVSPSLPPYD--- 331 Query: 285 IINDRHFQRVKGLIDNQKVAHGGTWDQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVC 344 + ++ V + Sbjct: 332 --HPIGYEWALDSEREATV-------------------------------------TVAR 352 Query: 345 VRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVTANDVI 392 V + EA++ N+ LA + + + + ++ GV N Sbjct: 353 VDGVAEAVRIANEETSGLAAGIATEDARAAEEFFDGYQGTGVFWNAPT 400 >5MMM-i nrPDB Length = 208 Score = 32.9 bits (74), Expect = 0.27, Method: Composition-based stats. Identities = 9/67 (13%), Positives = 21/67 (31%), Gaps = 6/67 (8%) Query: 215 SPCYVDKDCDLDVACRRIAWGKFMNS-----GQTCVAPDYILCDPSIQNQIVEKLKKSLK 269 +P V + DL+ + G F G+ A ++ + + + + + Sbjct: 56 APVEVAETADLEKFVKSRLPGGFAAQTVIGTGRRKCAIARVVLQEGTG-KFIINYRDAKE 114 Query: 270 DFYGEDA 276 G Sbjct: 115 YLQGNPL 121 >5X8R-i nrPDB Length = 157 Score = 32.5 bits (73), Expect = 0.36, Method: Composition-based stats. Identities = 9/67 (13%), Positives = 21/67 (31%), Gaps = 6/67 (8%) Query: 215 SPCYVDKDCDLDVACRRIAWGKFMNS-----GQTCVAPDYILCDPSIQNQIVEKLKKSLK 269 +P V + DL+ + G F G+ A ++ + + + + + Sbjct: 5 APVEVAETADLEKFVKSRLPGGFAAQTVIGTGRRKCAIARVVLQEGTG-KFIINYRDAKE 63 Query: 270 DFYGEDA 276 G Sbjct: 64 YLQGNPL 70 >1ZBM-A nrPDB Length = 280 Score = 31.8 bits (71), Expect = 0.61, Method: Composition-based stats. Identities = 19/129 (14%), Positives = 41/129 (31%), Gaps = 27/129 (20%) Query: 276 AKQSRDYGRIINDRH-------FQRVKGLIDNQKVAHGGTWDQSSRYIAPTILVDVDPQS 328 + D G +I++ + V L D I + V+V + Sbjct: 141 LDEEVDAGLLIHEGQITYADYGLKCVLDLWDWWSEQVKLPLPLGLNAIRRDLSVEVQEEF 200 Query: 329 -PVMQEEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAETSSGGVT 387 M+E I + + +EAI++ + + L + + K+ + Sbjct: 201 LRAMRESI------AFAIENPDEAIEYAMKYSRGL-------DRERAKRFA------MMY 241 Query: 388 ANDVIVHIT 396 ND ++ Sbjct: 242 VNDYTYNMP 250 >3OD1-A nrPDB Length = 400 Score = 31.0 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 17/108 (15%), Positives = 36/108 (33%), Gaps = 8/108 (7%) Query: 52 LGKNEWTSYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVI 111 + K + L E T K + D +E + + E +GVV I Sbjct: 4 MSKPFMFEKPFGMRDTLPEWYKTKKNICDQMTEEINLWGYDMIETPTLEYYETVGVVSAI 63 Query: 112 GAWNYPFNLTIQPMVGAVAAGNAVILKPSEVSGHMADLLATLIPQYMD 159 + + ++ GN ++L+P + + ++L + Sbjct: 64 ------LDQQLFKLLD--QQGNTLVLRPDMTAPIARLVASSLKDRAYP 103 >2R70-A nrPDB Length = 852 Score = 30.6 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 10/52 (19%), Positives = 16/52 (30%), Gaps = 3/52 (5%) Query: 73 TTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVIGAWNYPFNLTIQP 124 P E++ + +Q + E L +V WNYP Sbjct: 601 FCSAAYPKGVENKSLKSKVGIEQAYKVVRYEALRLVGG---WNYPLLNKACK 649 >5XHW-A nrPDB Length = 237 Score = 30.2 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 12/60 (20%), Positives = 22/60 (36%), Gaps = 1/60 (1%) Query: 53 GKNEWTSYYEEVAH-VLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVVLVI 111 GK E + ++ + ++ D+ D + + D I +EPLG I Sbjct: 43 GKPFLYRLMEYLEDQGVQRIILSLSYKADYIIDSLIKDNPVNSKVDFIIENEPLGTGGAI 102 >6GKZ-A nrPDB Length = 351 Score = 30.2 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 6/63 (9%), Positives = 22/63 (34%) Query: 43 SISGALASDLGKNEWTSYYEEVAHVLEELDTTIKELPDWAEDEPVAKTRQTQQDDLYIHS 102 ++ ++ + E+ ++ + ++++ +W + + H Sbjct: 178 KLADITTHEMAETYDRILVIELFEHMKNYELLLRKISEWISKDGLLFLEHICHKTFAYHY 237 Query: 103 EPL 105 EPL Sbjct: 238 EPL 240 >3DOD-A nrPDB Length = 448 Score = 29.8 bits (66), Expect = 2.2, Method: Composition-based stats. Identities = 6/22 (27%), Positives = 12/22 (54%) Query: 26 RIQQLEALQRMINENLKSISGA 47 R Q L L +++ E+ + I+ Sbjct: 193 RDQCLRELAQLLEEHHEEIAAL 214 >6C49-A nrPDB Length = 350 Score = 29.8 bits (66), Expect = 2.6, Method: Composition-based stats. Identities = 20/119 (16%), Positives = 39/119 (32%), Gaps = 27/119 (22%) Query: 140 SEVSGHMADLLATLIPQYMDQNLYLVVKGGVPETTELLKERFDHIMYTGSTAVGKIVMAA 199 S ++ + + L + + ++ ++ G T TGS A + ++ Sbjct: 259 STLAPNGSLHFLGLTLEPVPVSVGSLIDGAKSVTG----------SPTGSPAALRQLLKF 308 Query: 200 AAKHLTPVTLELGGKSPCYVDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQN 258 AA+ +EL L+ A R+ +SGQ A I+ Sbjct: 309 AARKKIAPQIEL--------FPMSQLNEAIERL------HSGQ---ARYRIVLKADFAE 350 >3C3E-A nrPDB Length = 311 Score = 29.5 bits (65), Expect = 3.0, Method: Composition-based stats. Identities = 15/106 (14%), Positives = 37/106 (34%), Gaps = 7/106 (6%) Query: 253 DPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIIND---RHFQRVKGLIDNQKVAHGGTW 309 + SI +++E +K ++ + G II+ R + K ++ + Sbjct: 170 EASISPKVLEAFEKE-ENILIGPSNPITSIGPIISLPGMRELLKKKKVVAVSPIIGNAPV 228 Query: 310 DQSSRYIAPTILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQFI 355 + + P ++V V E + + + + A +F Sbjct: 229 SGPAGKLMPACGIEVS-SMGVA--EYYQDFLDVFVFDERDRADEFA 271 >3LOO-A nrPDB Length = 365 Score = 29.5 bits (65), Expect = 3.1, Method: Composition-based stats. Identities = 12/49 (24%), Positives = 20/49 (40%), Gaps = 8/49 (16%) Query: 333 EEIFGPVMPIVCVRSLEEAIQFINQREKPLALYVFSNNEKVIKKMIAET 381 EEIF P + ++ + EAI + + + + I K IA Sbjct: 226 EEIF-PYVDVL-FGNETEAIALAKEFNYG------TEDLREIGKRIAAL 266 >3R11-A nrPDB Length = 379 Score = 29.5 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 12/62 (19%), Positives = 21/62 (33%), Gaps = 3/62 (4%) Query: 297 LIDNQKVAHGGTWDQSSRYIAPT---ILVDVDPQSPVMQEEIFGPVMPIVCVRSLEEAIQ 353 ID+ V +AP I D + EIF PV+ + ++ ++ Sbjct: 30 HIDSLAVELTLDNGVKGYGVAPATTAITGDTLQGMQYIIREIFAPVILGSDLSDYKQTLE 89 Query: 354 FI 355 Sbjct: 90 LA 91 >5T2K-A nrPDB Length = 248 Score = 29.5 bits (65), Expect = 3.6, Method: Composition-based stats. Identities = 13/94 (13%), Positives = 31/94 (32%), Gaps = 7/94 (7%) Query: 15 FNSGKTRSLQFRIQQLEALQRMINENLKSISGALASDLGKNEWTSYYEEVAHVLEELDTT 74 +++ KT + R + ++++ ++ K + Y V + L Sbjct: 22 WSAWKTLPNEEREAAISEFLALVDQ-------WETTESEKQGSHAVYTIVGQKADILFMI 74 Query: 75 IKELPDWAEDEPVAKTRQTQQDDLYIHSEPLGVV 108 ++ D + A + D L + VV Sbjct: 75 LRPTLDELHEIETALNKTKLADYLLPAYSYVSVV 108 >5ZZ8-q nrPDB Length = 702 Score = 29.1 bits (64), Expect = 4.3, Method: Composition-based stats. Identities = 9/68 (13%), Positives = 19/68 (27%) Query: 251 LCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIINDRHFQRVKGLIDNQKVAHGGTWD 310 L ++Q+ ++ G +++ G D + V G Sbjct: 260 LVQRAVQDVTRRHPVRARPKHAASGVASGLRQGALVHQAVSGGALGASDAEAVLAGLEPP 319 Query: 311 QSSRYIAP 318 R+ P Sbjct: 320 GGGRFATP 327 >2OYO-A nrPDB Length = 196 Score = 28.7 bits (63), Expect = 5.0, Method: Composition-based stats. Identities = 7/39 (17%), Positives = 15/39 (38%) Query: 9 KRAREAFNSGKTRSLQFRIQQLEALQRMINENLKSISGA 47 ++A + + L R Q L A + + ++ A Sbjct: 110 QKADAVAVNWRHADLTEREQALAAYAEKLTRHPAEVTAA 148 >5KQU-A nrPDB Length = 479 Score = 28.7 bits (63), Expect = 5.2, Method: Composition-based stats. Identities = 13/129 (10%), Positives = 36/129 (27%), Gaps = 18/129 (13%) Query: 223 CDLD------VACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKDFYGEDA 276 +LD + G ++N + L + ++ L+ Sbjct: 358 ANLDILERENLTANAADVGAYLNQRLRETFEGHPLVGEVRGDGMLAALEFMADREARTPF 417 Query: 277 KQSRDYGRIINDRHFQRVKGLIDNQKVAHGGTWDQSSRYIAPTILVDVDPQ-----SPVM 331 + G ++ +++ +A + P +L + + Sbjct: 418 DPALKVGPKVSA-------ACLEDGMIARAMPHGDILGFAPPLVLTRAEADEIVGIAKAA 470 Query: 332 QEEIFGPVM 340 +E+ G V+ Sbjct: 471 VDEVAGEVL 479 >6DEO-A nrPDB Length = 682 Score = 28.7 bits (63), Expect = 6.2, Method: Composition-based stats. Identities = 10/91 (10%), Positives = 35/91 (38%), Gaps = 8/91 (8%) Query: 251 LCDPSIQNQIVEKLKKSLKDFYGEDAKQSRDYGRIIN-----DRHFQRVKGLIDNQKVAH 305 + I + + K+ ++ + G+ + + +++ F ++ +K + Sbjct: 398 ILHFEISPKNINKVVEATEAIEGDVTANLQSFIPLVDSIENRPEWFNKINEW--KKKYPY 455 Query: 306 GGTWDQSSRYIAP-TILVDVDPQSPVMQEEI 335 + I P T++ ++ Q+ +E+ Sbjct: 456 SYQLETPGSLIKPQTLIKEISDQAQTYNKEV 486 >5WYK-3D nrPDB Length = 504 Score = 27.9 bits (61), Expect = 8.2, Method: Composition-based stats. Identities = 10/51 (19%), Positives = 20/51 (39%), Gaps = 8/51 (15%) Query: 322 VDVDPQSPVMQEEI--FGP------VMPIVCVRSLEEAIQFINQREKPLAL 364 D+ + +QE+I FG ++ + EA++ N + L Sbjct: 25 DDIGSRLKEVQEQINDFGAFTKLIELVSFAPFKGAAEALENANDISEGLVS 75 >3UF0-A nrPDB Length = 273 Score = 27.9 bits (61), Expect = 9.4, Method: Composition-based stats. Identities = 15/72 (20%), Positives = 20/72 (27%), Gaps = 12/72 (16%) Query: 165 VVKGGVPETTELLKERFDHIMYTGSTAVGKIVMAAA-AKHLTPVTLE---LGGKSPCYVD 220 VV G + G G V+A + V E GG + V Sbjct: 35 VVTGAGSGIGRAIAH--------GYARAGAHVLAWGRTDGVKEVADEIADGGGSAEAVVA 86 Query: 221 KDCDLDVACRRI 232 DL+ A Sbjct: 87 DLADLEGAANVA 98 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.312 0.152 0.442 Lambda K H 0.267 0.0465 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 19,241,683 Number of Sequences: 36641 Number of extensions: 876699 Number of successful extensions: 3744 Number of sequences better than 10.0: 143 Number of HSP's better than 10.0 without gapping: 217 Number of HSP's successfully gapped in prelim test: 46 Number of HSP's that attempted gapping in prelim test: 2570 Number of HSP's gapped (non-prelim): 289 length of query: 453 length of database: 10,336,785 effective HSP length: 100 effective length of query: 353 effective length of database: 6,672,685 effective search space: 2355457805 effective search space used: 2355457805 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 61 (27.9 bits)