BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P11802 (303 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2W96-B nrPDB 605 e-173 1G3N-A nrPDB 430 e-121 2BPM-A nrPDB 246 7e-66 6GU6-A nrPDB 236 1e-62 1V0B-A nrPDB 234 2e-62 3NIZ-A nrPDB 233 1e-61 4AU8-A nrPDB 232 1e-61 4KRC-A nrPDB 218 3e-57 5G6V-A nrPDB 206 1e-53 3GC0-A nrPDB 199 8e-52 1UA2-A nrPDB 193 6e-50 5EFQ-A nrPDB 189 1e-48 4NST-A nrPDB 189 2e-48 3MIA-A nrPDB 177 5e-45 6DTL-A nrPDB 176 1e-44 5NGU-A nrPDB 173 1e-43 4ZSG-A nrPDB 171 5e-43 4CRL-A nrPDB 169 1e-42 4IC8-A nrPDB 169 1e-42 2F9G-A nrPDB 167 3e-42 4QTB-A nrPDB 167 5e-42 3N9X-A nrPDB 164 4e-41 3FI2-A nrPDB 159 1e-39 1JNK-A nrPDB 159 1e-39 5Z33-A nrPDB 157 5e-39 4BBM-A nrPDB 157 7e-39 3E7O-A nrPDB 155 1e-38 4AGU-A nrPDB 155 3e-38 3ZDU-A nrPDB 154 3e-38 2I6L-A nrPDB 153 8e-38 3NIE-A nrPDB 152 1e-37 4BGQ-A nrPDB 152 2e-37 3OZ6-A nrPDB 150 4e-37 1CM8-A nrPDB 150 6e-37 3GC9-A nrPDB 149 1e-36 4O2Z-A nrPDB 149 1e-36 4EWQ-A nrPDB 149 2e-36 3RP9-A nrPDB 147 5e-36 4MYG-A nrPDB 147 7e-36 3OHT-A nrPDB 147 7e-36 2XS0-A nrPDB 147 8e-36 5AWM-A nrPDB 146 8e-36 4QNY-A nrPDB 144 4e-35 3PG1-A nrPDB 144 5e-35 5Y86-A nrPDB 135 3e-32 3E3P-A nrPDB 130 5e-31 5ZTN-A nrPDB 129 2e-30 4E7W-A nrPDB 125 2e-29 3EB0-A nrPDB 123 1e-28 5AIR-A nrPDB 123 1e-28 2WO6-A nrPDB 122 2e-28 3NCG-A nrPDB 111 3e-25 3DFA-A nrPDB 110 1e-24 3LIJ-A nrPDB 108 2e-24 5XVU-A nrPDB 107 5e-24 3HZT-A nrPDB 106 1e-23 4RGJ-A nrPDB 106 1e-23 6O6Q-A nrPDB 106 1e-23 3DXN-A nrPDB 105 2e-23 4IAN-A nrPDB 102 1e-22 2JD5-A nrPDB 102 2e-22 2W4O-A nrPDB 102 3e-22 5JN2-A nrPDB 102 3e-22 2VN9-A nrPDB 101 3e-22 3MA6-A nrPDB 101 3e-22 2X7G-A nrPDB 101 4e-22 3Q5I-A nrPDB 100 6e-22 3RAW-A nrPDB 100 1e-21 6QAU-A nrPDB 99 2e-21 4LFI-A nrPDB 99 2e-21 2PVN-A nrPDB 98 3e-21 6EII-A nrPDB 98 4e-21 6FD3-A nrPDB 97 6e-21 4MD7-E nrPDB 97 6e-21 5FG8-A nrPDB 97 7e-21 2XNP-A nrPDB 97 9e-21 6FYV-A nrPDB 96 1e-20 3BHH-A nrPDB 96 1e-20 3KK8-A nrPDB 96 2e-20 2BDW-A nrPDB 96 2e-20 3Q53-A nrPDB 96 2e-20 3MN3-A nrPDB 95 3e-20 2V7O-A nrPDB 95 3e-20 2VZ6-A nrPDB 95 3e-20 4WUA-A nrPDB 95 4e-20 2XIK-A nrPDB 95 4e-20 5YKS-A nrPDB 94 5e-20 2WQN-A nrPDB 94 5e-20 5U6Y-A nrPDB 94 7e-20 4QMW-A nrPDB 93 1e-19 5X8I-B nrPDB 92 2e-19 4RED-A nrPDB 92 2e-19 4REW-A nrPDB 92 3e-19 2GCD-A nrPDB 92 3e-19 3SOA-A nrPDB 92 4e-19 1U5R-A nrPDB 92 4e-19 4CFH-A nrPDB 91 4e-19 2YAB-A nrPDB 91 5e-19 4MVF-A nrPDB 91 7e-19 2Y7J-A nrPDB 91 7e-19 5UNP-A nrPDB 91 8e-19 6HMD-A nrPDB 90 1e-18 5XZW-A nrPDB 90 1e-18 4KS7-A nrPDB 90 1e-18 3GUB-A nrPDB 90 1e-18 4YZB-A nrPDB 90 1e-18 2YZA-A nrPDB 90 2e-18 4CFF-A nrPDB 89 2e-18 1ZWS-A nrPDB 89 2e-18 5EZV-A nrPDB 89 2e-18 3COM-A nrPDB 89 2e-18 2A27-A nrPDB 89 2e-18 4WNO-A nrPDB 89 2e-18 2J90-A nrPDB 89 2e-18 6CMJ-A nrPDB 89 3e-18 4FG9-A nrPDB 89 3e-18 2WTK-C nrPDB 89 3e-18 4E93-A nrPDB 87 6e-18 1ZXE-A nrPDB 87 6e-18 1PHK-A nrPDB 87 9e-18 4KIK-B nrPDB 87 1e-17 3H4J-B nrPDB 87 1e-17 3UTO-A nrPDB 86 1e-17 4LG4-A nrPDB 86 2e-17 1KOA-A nrPDB 86 2e-17 4PDS-A nrPDB 86 2e-17 6AO5-A nrPDB 86 2e-17 6HXF-B nrPDB 86 2e-17 2Z7Q-A nrPDB 86 3e-17 2X4F-A nrPDB 86 3e-17 4APC-A nrPDB 86 3e-17 4JXF-A nrPDB 85 3e-17 4L42-A nrPDB 85 3e-17 2JAM-A nrPDB 85 4e-17 4RLP-A nrPDB 85 4e-17 4EQM-A nrPDB 85 4e-17 1KOB-A nrPDB 84 7e-17 1LUF-A nrPDB 84 8e-17 2JC6-A nrPDB 84 8e-17 4CZT-A nrPDB 84 9e-17 6CCF-A nrPDB 84 1e-16 2A1A-B nrPDB 83 1e-16 2F57-A nrPDB 83 1e-16 3TAC-A nrPDB 83 1e-16 2BRG-A nrPDB 83 2e-16 4UZD-A nrPDB 83 2e-16 4M7I-A nrPDB 82 2e-16 4YNZ-A nrPDB 82 3e-16 5YV8-A nrPDB 82 3e-16 6DBN-A nrPDB 82 4e-16 4AN9-A nrPDB 82 4e-16 2UV2-A nrPDB 82 4e-16 6CQF-A nrPDB 81 4e-16 5J5T-A nrPDB 81 5e-16 5KKR-C nrPDB 81 6e-16 3DLS-A nrPDB 81 6e-16 6E2O-A nrPDB 81 6e-16 5JZN-A nrPDB 81 6e-16 3EQC-A nrPDB 81 6e-16 3QA8-A nrPDB 81 7e-16 5D7A-A nrPDB 80 7e-16 4CSV-A nrPDB 80 9e-16 3HKO-A nrPDB 80 9e-16 1S9I-A nrPDB 80 1e-15 1FOT-A nrPDB 80 1e-15 4PWN-A nrPDB 80 1e-15 3D2K-A nrPDB 80 1e-15 4FZF-B nrPDB 80 1e-15 5ES1-A nrPDB 80 2e-15 4C59-A nrPDB 79 2e-15 5KZ7-A nrPDB 79 2e-15 6FDY-U nrPDB 79 2e-15 4U41-A nrPDB 79 2e-15 2QNJ-A nrPDB 79 2e-15 3KA0-A nrPDB 79 3e-15 2OZA-A nrPDB 78 4e-15 1NY3-A nrPDB 78 4e-15 2YCR-A nrPDB 78 5e-15 4CQG-A nrPDB 78 5e-15 6C9D-A nrPDB 78 5e-15 3UIU-A nrPDB 78 5e-15 2BUJ-A nrPDB 78 6e-15 3VN9-A nrPDB 77 7e-15 2PSQ-A nrPDB 77 8e-15 2HAK-A nrPDB 77 8e-15 5DYK-A nrPDB 77 8e-15 3IS5-A nrPDB 77 8e-15 3LM0-A nrPDB 77 9e-15 5F9E-A nrPDB 77 1e-14 4FR4-A nrPDB 77 1e-14 5O2C-A nrPDB 77 1e-14 3I6U-A nrPDB 77 1e-14 5O2B-A nrPDB 77 1e-14 3ORP-A nrPDB 77 1e-14 4GS6-A nrPDB 77 1e-14 3FXW-A nrPDB 77 1e-14 3GQL-A nrPDB 77 1e-14 5TQX-A nrPDB 77 1e-14 5A46-A nrPDB 76 1e-14 4D28-A nrPDB 76 1e-14 3TT0-A nrPDB 76 1e-14 6CTH-A nrPDB 76 2e-14 2W1I-A nrPDB 76 2e-14 3IO7-A nrPDB 76 2e-14 4D2V-A nrPDB 76 2e-14 5EG3-A nrPDB 76 2e-14 3ZZW-A nrPDB 76 2e-14 6HV0-A nrPDB 75 2e-14 4B6L-A nrPDB 75 2e-14 3ORZ-A nrPDB 75 3e-14 4UY9-A nrPDB 75 3e-14 3UDB-A nrPDB 75 3e-14 5VO2-A nrPDB 75 3e-14 5FET-A nrPDB 75 4e-14 4NIF-A nrPDB 75 4e-14 3DTC-A nrPDB 75 5e-14 5D9K-A nrPDB 75 5e-14 3QGY-A nrPDB 75 5e-14 3FME-A nrPDB 74 6e-14 4XBR-A nrPDB 74 7e-14 5HI2-A nrPDB 74 7e-14 4K33-A nrPDB 74 8e-14 4XLV-A nrPDB 74 1e-13 4XCU-A nrPDB 74 1e-13 2Q0N-A nrPDB 73 1e-13 4UYA-A nrPDB 73 1e-13 4B8L-A nrPDB 73 1e-13 4JDH-A nrPDB 73 1e-13 4JG6-A nrPDB 73 1e-13 4C0T-A nrPDB 73 1e-13 3LLT-A nrPDB 73 2e-13 3KN6-A nrPDB 73 2e-13 4OW8-A nrPDB 72 2e-13 4FIE-A nrPDB 72 2e-13 6B2Q-A nrPDB 72 2e-13 4X3F-A nrPDB 72 3e-13 3F3Z-A nrPDB 72 3e-13 6BXI-A nrPDB 72 4e-13 5IG1-A nrPDB 72 4e-13 4TNB-A nrPDB 72 4e-13 2OU7-A nrPDB 72 4e-13 3ZUT-A nrPDB 71 5e-13 3DB8-A nrPDB 71 5e-13 6FER-A nrPDB 71 6e-13 4J52-A nrPDB 71 6e-13 3UC3-A nrPDB 71 6e-13 5WAX-A nrPDB 71 7e-13 5VD3-A nrPDB 70 9e-13 4AF3-A nrPDB 70 9e-13 5MJB-A nrPDB 70 1e-12 2PL0-A nrPDB 70 1e-12 2RIO-A nrPDB 70 1e-12 4E20-A nrPDB 70 1e-12 3TXO-A nrPDB 70 1e-12 5O0Y-A nrPDB 70 1e-12 3HDN-A nrPDB 70 1e-12 5X02-A nrPDB 70 1e-12 3OMV-A nrPDB 69 2e-12 2HW6-A nrPDB 69 2e-12 5L6P-A nrPDB 69 2e-12 5LOH-A nrPDB 69 2e-12 4XUF-A nrPDB 69 3e-12 4HVI-A nrPDB 69 3e-12 5IKW-A nrPDB 69 3e-12 3QUP-A nrPDB 68 4e-12 6DBM-A nrPDB 68 4e-12 5TOS-A nrPDB 68 5e-12 4TPT-A nrPDB 68 5e-12 5GRN-A nrPDB 68 6e-12 3NYO-A nrPDB 68 6e-12 4RA4-A nrPDB 68 6e-12 4OLI-A nrPDB 67 7e-12 3UIM-A nrPDB 67 7e-12 5U6C-A nrPDB 67 7e-12 4I6B-A nrPDB 67 7e-12 4PL5-B nrPDB 67 8e-12 5KMM-A nrPDB 67 8e-12 5LPZ-A nrPDB 67 8e-12 5N23-A nrPDB 67 8e-12 4LRM-A nrPDB 67 9e-12 5LPV-A nrPDB 67 1e-11 4JLC-A nrPDB 67 1e-11 3KRL-A nrPDB 67 1e-11 5H2U-A nrPDB 67 1e-11 2QKW-B nrPDB 67 1e-11 6GQK-A nrPDB 66 1e-11 6NPU-A nrPDB 66 1e-11 6BDL-A nrPDB 66 2e-11 2VWV-A nrPDB 66 2e-11 4EUU-A nrPDB 66 2e-11 4XEY-B nrPDB 66 2e-11 3HNG-A nrPDB 66 2e-11 2DQ7-X nrPDB 66 2e-11 4AT3-A nrPDB 66 2e-11 3LZB-A nrPDB 66 2e-11 5GNK-A nrPDB 66 2e-11 3C1X-A nrPDB 66 2e-11 4EUT-A nrPDB 65 2e-11 2JDO-A nrPDB 65 3e-11 5AMN-A nrPDB 65 3e-11 2XYN-A nrPDB 65 3e-11 4RT7-A nrPDB 65 3e-11 4YHJ-A nrPDB 65 3e-11 2FO0-A nrPDB 65 4e-11 3PVW-A nrPDB 65 4e-11 5HIE-A nrPDB 65 4e-11 6NT9-A nrPDB 65 4e-11 5UUU-A nrPDB 65 4e-11 3ALO-A nrPDB 65 4e-11 6O8B-A nrPDB 65 5e-11 5X3F-B nrPDB 65 5e-11 5HLW-A nrPDB 64 5e-11 4WB7-A nrPDB 64 5e-11 4P5Q-A nrPDB 64 8e-11 3BBT-B nrPDB 64 8e-11 3V5Q-A nrPDB 64 9e-11 3SXS-A nrPDB 64 9e-11 2PMN-X nrPDB 64 1e-10 5U6B-A nrPDB 64 1e-10 4XI2-A nrPDB 64 1e-10 3PPZ-A nrPDB 63 1e-10 2I0E-A nrPDB 63 1e-10 3PFQ-A nrPDB 63 1e-10 5DBX-A nrPDB 63 1e-10 3A8W-A nrPDB 63 1e-10 6FEX-A nrPDB 63 2e-10 3DAK-A nrPDB 63 2e-10 1FVR-A nrPDB 63 2e-10 2OGV-A nrPDB 62 2e-10 5HVK-A nrPDB 62 2e-10 3CJF-A nrPDB 62 2e-10 1BYG-A nrPDB 62 3e-10 5B2L-A nrPDB 62 3e-10 4NEU-A nrPDB 62 3e-10 5X5O-A nrPDB 62 3e-10 3MV5-A nrPDB 62 3e-10 6E4F-A nrPDB 62 4e-10 4R7H-A nrPDB 62 4e-10 2Y6O-A nrPDB 62 4e-10 3KUL-B nrPDB 62 4e-10 5KCV-A nrPDB 62 4e-10 1K9A-A nrPDB 62 4e-10 3C51-A nrPDB 62 4e-10 3ZBF-A nrPDB 62 4e-10 2R2P-A nrPDB 61 5e-10 6J5U-C nrPDB 61 6e-10 4Y93-A nrPDB 61 6e-10 3AOX-A nrPDB 61 6e-10 3I81-A nrPDB 61 6e-10 1VZO-A nrPDB 61 6e-10 1U59-A nrPDB 61 7e-10 3QD2-B nrPDB 61 7e-10 1JPA-A nrPDB 61 7e-10 6BSD-A nrPDB 61 8e-10 5XD6-A nrPDB 60 9e-10 1AD5-A nrPDB 60 1e-09 3BEA-A nrPDB 60 1e-09 4AW2-A nrPDB 60 1e-09 4FL3-A nrPDB 60 1e-09 3A4O-X nrPDB 60 2e-09 2VD5-A nrPDB 60 2e-09 2HK5-A nrPDB 59 2e-09 4EBW-A nrPDB 59 2e-09 3VHK-A nrPDB 59 2e-09 5C26-A nrPDB 59 2e-09 6F3F-A nrPDB 59 2e-09 2OZO-A nrPDB 59 2e-09 6GVJ-A nrPDB 59 3e-09 3PLS-A nrPDB 59 3e-09 2H8H-A nrPDB 59 3e-09 4Y83-A nrPDB 59 3e-09 3HMP-A nrPDB 59 3e-09 5UIU-A nrPDB 59 4e-09 4X7Q-B nrPDB 59 4e-09 2H34-A nrPDB 58 4e-09 6ED6-A nrPDB 58 4e-09 4PDO-A nrPDB 58 5e-09 1TKI-A nrPDB 58 5e-09 3DKO-A nrPDB 58 6e-09 5AP3-A nrPDB 57 7e-09 3PP0-A nrPDB 57 7e-09 2J0K-A nrPDB 57 7e-09 5FM2-A nrPDB 57 1e-08 5WNL-A nrPDB 57 1e-08 3TKU-A nrPDB 57 1e-08 6BFN-A nrPDB 57 1e-08 3G0E-A nrPDB 57 1e-08 6CKI-A nrPDB 57 1e-08 5SYS-A nrPDB 57 1e-08 2ZMD-A nrPDB 56 2e-08 6E9W-A nrPDB 56 2e-08 3MDY-A nrPDB 56 2e-08 3M42-A nrPDB 56 2e-08 4OTD-A nrPDB 55 3e-08 5WNO-A nrPDB 55 4e-08 3G2F-A nrPDB 55 5e-08 4YFF-A nrPDB 55 5e-08 4G3E-A nrPDB 54 6e-08 4CRS-A nrPDB 54 9e-08 4IDT-A nrPDB 54 1e-07 3Q4U-A nrPDB 53 1e-07 4F9B-A nrPDB 53 1e-07 5TUR-A nrPDB 53 2e-07 4BTK-A nrPDB 53 2e-07 4RC3-A nrPDB 53 2e-07 4NFN-A nrPDB 53 2e-07 3BGP-A nrPDB 53 2e-07 3LMG-A nrPDB 52 3e-07 1U54-B nrPDB 52 4e-07 4HZS-A nrPDB 52 4e-07 1PY5-A nrPDB 51 5e-07 4H1J-A nrPDB 50 1e-06 4F0G-A nrPDB 50 1e-06 5VC6-A nrPDB 50 2e-06 5TE0-A nrPDB 49 2e-06 5E8V-A nrPDB 49 4e-06 5VDK-A nrPDB 47 1e-05 4M69-B nrPDB 47 1e-05 4Y12-A nrPDB 47 1e-05 4BTF-A nrPDB 46 2e-05 2Y4I-B nrPDB 46 2e-05 3MY0-A nrPDB 46 2e-05 4JRN-A nrPDB 46 2e-05 2PZI-A nrPDB 46 3e-05 5OAT-A nrPDB 45 3e-05 3SOC-A nrPDB 45 4e-05 4TN6-A nrPDB 45 5e-05 2QLU-A nrPDB 45 5e-05 5M07-A nrPDB 44 7e-05 4M66-A nrPDB 44 1e-04 3SV0-A nrPDB 44 1e-04 4MWI-A nrPDB 43 1e-04 2WTK-B nrPDB 42 4e-04 4LQP-A nrPDB 41 5e-04 4IX6-A nrPDB 41 6e-04 5FQD-C nrPDB 41 6e-04 2C47-A nrPDB 41 7e-04 4NT4-A nrPDB 41 7e-04 2CMW-A nrPDB 40 8e-04 4XHH-A nrPDB 40 0.001 4XHL-A nrPDB 40 0.001 5X1R-A nrPDB 39 0.002 5AR8-A nrPDB 39 0.002 2JII-A nrPDB 39 0.003 4CYJ-A nrPDB 39 0.004 5X18-A nrPDB 38 0.006 4O1O-A nrPDB 38 0.006 5L2Q-C nrPDB 38 0.007 2CHL-A nrPDB 37 0.013 4OAU-C nrPDB 36 0.016 1CSN-A nrPDB 35 0.030 6G4J-A nrPDB 34 0.093 4WWA-A nrPDB 33 0.12 4L68-A nrPDB 33 0.16 6EQI-C nrPDB 33 0.17 5UU1-A nrPDB 32 0.25 2RSV-A nrPDB 32 0.38 5CLR-A nrPDB 32 0.42 2LAV-A nrPDB 32 0.43 1EU1-A nrPDB 31 0.60 5DLD-A nrPDB 31 0.70 4CI6-B nrPDB 30 0.94 6J6I-B nrPDB 30 1.2 5YPX-A nrPDB 30 1.4 4AZV-A nrPDB 30 1.7 5VE6-A nrPDB 29 2.0 6EWX-A nrPDB 29 2.2 4AZW-A nrPDB 29 2.2 4LRY-C nrPDB 29 3.0 5TX1-A nrPDB 29 3.1 5BO0-D nrPDB 28 3.7 3QLB-A nrPDB 28 4.2 2XN1-A nrPDB 28 5.2 2GB3-A nrPDB 28 5.5 3REP-A nrPDB 27 8.4 2ZC0-A nrPDB 27 9.6 >2W96-B nrPDB Length = 306 Score = 605 bits (1559), Expect = e-173, Method: Compositional matrix adjust. Identities = 297/303 (98%), Positives = 297/303 (98%), Gaps = 3/303 (0%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNG G LPISTVREVALL Sbjct: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGEEG---LPISTVREVALL 57 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL Sbjct: 58 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 117 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY 180 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL PVVVTLWY Sbjct: 118 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWY 177 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR Sbjct: 178 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 237 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 300 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG Sbjct: 238 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 297 Query: 301 NPE 303 NPE Sbjct: 298 NPE 300 >1G3N-A nrPDB Length = 326 Score = 430 bits (1106), Expect = e-121, Method: Compositional matrix adjust. Identities = 211/303 (69%), Positives = 243/303 (80%), Gaps = 4/303 (1%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARD-PHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 A +YE VAEIG GAYG V+KARD + G FVALK VRV G G +P+ST+REVA+L Sbjct: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEG---MPLSTIREVAVL 65 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 R LE FEHPNVVRL DVC SRTDRE K+TLVFEHVDQDL TYLDK P PG+P ETIKD+ Sbjct: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDM 125 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY 180 M Q LRGLDFLH++ +VHRDLKP+NILVTS G +KLADFGLARIYS+QMALT VVVTLWY Sbjct: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWY 185 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 RAPEVLLQS+YATPVD+WSVGCIFAEMFRRKPLF G+S+ DQLGKI D+IGLP E+DWPR Sbjct: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 300 DV+LPR AF + +P++ V +++E G LLL+ LTFNP KRISA+ AL H Y E Sbjct: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 Query: 301 NPE 303 E Sbjct: 306 CKE 308 >2BPM-A nrPDB Length = 309 Score = 246 bits (629), Expect = 7e-66, Method: Compositional matrix adjust. Identities = 134/295 (45%), Positives = 189/295 (64%), Gaps = 15/295 (5%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 ++ V +IG G YG VYKAR+ +G VALK +R+ G +P + +RE++LL+ L Sbjct: 9 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEG---VPSTAIREISLLKELN- 64 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 HPN+V+L+DV T E K+ LVFE + QDL+ ++D + G+P IK + Q L Sbjct: 65 --HPNIVKLLDVIHT-----ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLL 117 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPE 184 +GL F H++ ++HRDLKP+N+L+ + G +KLADFGLAR + + T VVTLWYRAPE Sbjct: 118 QGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 177 Query: 185 VLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 +LL Y+T VD+WS+GCIFAEM R+ LF G+SE DQL +IF +G P E WP S Sbjct: 178 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 237 Query: 244 LP--RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 +P + +FP + VVP ++E G LL +ML ++P+KRISA AL H + Sbjct: 238 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQ 292 >6GU6-A nrPDB Length = 302 Score = 236 bits (602), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 128/296 (43%), Positives = 184/296 (62%), Gaps = 16/296 (5%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y + +IG G YG VYK R +G VA+K +R+ + G +P + +RE++LL+ L Sbjct: 9 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEG---VPSTAIREISLLKELR- 64 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPP-PGLPAETIKDLMRQF 124 HPN+V L DV ++ ++ L+FE + DL+ YLD PP + + +K + Q Sbjct: 65 --HPNIVSLQDVLM-----QDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQI 117 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL-TPVVVTLWYRAP 183 L+G+ F H+ ++HRDLKP+N+L+ GT+KLADFGLAR + + + T VVTLWYR+P Sbjct: 118 LQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSP 177 Query: 184 EVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 EVLL S Y+TPVD+WS+G IFAE+ +KPLF G+SE DQL +IF +G P + WP Sbjct: 178 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 237 Query: 243 SLP--RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 SL + FP P + S V ++E+G LL +ML ++P KRIS AL H Y + Sbjct: 238 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 293 >1V0B-A nrPDB Length = 288 Score = 234 bits (598), Expect = 2e-62, Method: Compositional matrix adjust. Identities = 128/299 (42%), Positives = 188/299 (62%), Gaps = 17/299 (5%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 +Y + +IG G YG VYKA++ + G ALK +R+ G +P +T+RE+++L+ L Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEKEDEG---IPSTTIREISILKEL 57 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 + H N+V+L DV T + ++ LVFEH+DQDL+ LD GL + T K + Q Sbjct: 58 K---HSNIVKLYDVIHTKK-----RLVLVFEHLDQDLKKLLD-VCEGGLESVTAKSFLLQ 108 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRA 182 L G+ + H ++HRDLKP+N+L+ G +K+ADFGLAR + + T VVTLWYRA Sbjct: 109 LLNGIAYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYRA 168 Query: 183 PEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 P+VL+ S Y+T +D+WSVGCIFAEM PLF G SEADQL +IF ++G P +WP Sbjct: 169 PDVLMGSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNV 228 Query: 242 VSLPRG--AFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 LP+ F P P +S + ++ESG LL +ML +P++RI+A +AL+H+Y ++ Sbjct: 229 TELPKYDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKEN 287 >3NIZ-A nrPDB Length = 311 Score = 233 bits (593), Expect = 1e-61, Method: Compositional matrix adjust. Identities = 131/296 (44%), Positives = 184/296 (62%), Gaps = 18/296 (6%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 +Y+ + ++G G YG VYKA+D G VALK +R+ G+P + +RE++LL+ L Sbjct: 22 KYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRL---DAEDEGIPSTAIREISLLKELH 77 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 HPN+V L+DV + R +TLVFE +++DL+ LD+ GL IK + Q Sbjct: 78 ---HPNIVSLIDVIHSERC-----LTLVFEFMEKDLKKVLDENKT-GLQDSQIKIYLYQL 128 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAP 183 LRG+ H + I+HRDLKP+N+L+ S G +KLADFGLAR + + + T VVTLWYRAP Sbjct: 129 LRGVAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAP 188 Query: 184 EVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 +VL+ S Y+T VD+WS+GCIFAEM KPLF G ++ DQL KIF ++G P +WP+ Sbjct: 189 DVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQ 248 Query: 243 SLP---RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 LP + F +P S++P + G LL ML F+P+KRISA A+ H Y Sbjct: 249 ELPLWKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYF 304 >4AU8-A nrPDB Length = 296 Score = 232 bits (592), Expect = 1e-61, Method: Compositional matrix adjust. Identities = 132/300 (44%), Positives = 180/300 (60%), Gaps = 17/300 (5%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 M + +YE + +IG G YGTV+KA++ + VALK VR+ + G +P S +RE+ LL Sbjct: 3 MGSQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEG---VPSSALREICLL 59 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 + L+ H N+VRL DV + + K+TLVFE DQDL+ Y D L E +K Sbjct: 60 KELK---HKNIVRLHDVLHSDK-----KLTLVFEFCDQDLKKYFDSCNG-DLDPEIVKSF 110 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLW 179 + Q L+GL F H+ ++HRDLKP+N+L+ G +KLADFGLAR + + + VVTLW Sbjct: 111 LFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW 170 Query: 180 YRAPEVLLQST-YATPVDMWSVGCIFAEMFRR-KPLFCGNSEADQLGKIFDLIGLPPEDD 237 YR P+VL + Y+T +DMWS GCIFAE+ +PLF GN DQL +IF L+G P E+ Sbjct: 171 YRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQ 230 Query: 238 WPRDVSLPRGAFPPRGPRPVQ--SVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 WP LP P P +VVP++ +G LL +L NP +RISA ALQH Y Sbjct: 231 WPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 290 >4KRC-A nrPDB Length = 317 Score = 218 bits (555), Expect = 3e-57, Method: Compositional matrix adjust. Identities = 126/307 (41%), Positives = 182/307 (59%), Gaps = 25/307 (8%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 ++S+++ + ++G G Y TVYK + +G +VALK V++ + G P + +RE++L++ Sbjct: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGT----PSTAIREISLMK 58 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDK----APPPGLPAETI 117 L+ H N+VRL DV T E K+TLVFE +D DL+ Y+D P GL + Sbjct: 59 ELK---HENIVRLYDVIHT-----ENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLV 110 Query: 118 KDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVV 176 K Q L+GL F H N I+HRDLKP+N+L+ G +KL DFGLAR + + + VV Sbjct: 111 KYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV 170 Query: 177 TLWYRAPEVLLQS-TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPE 235 TLWYRAP+VL+ S TY+T +D+WS GCI AEM KPLF G ++ +QL IFD++G P E Sbjct: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNE 230 Query: 236 DDWPRDVSLPRG--AFPPRGPRPVQSVV-PEMEE----SGAQLLLEMLTFNPHKRISAFR 288 WP LP+ R PR ++ V+ P +E + L +L NP R+SA + Sbjct: 231 SLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ 290 Query: 289 ALQHSYL 295 AL H + Sbjct: 291 ALHHPWF 297 >5G6V-A nrPDB Length = 324 Score = 206 bits (524), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 117/295 (39%), Positives = 171/295 (57%), Gaps = 18/295 (6%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y + ++G G Y TVYK + + + VALK +R+ + G P + +REV+LL+ L+ Sbjct: 4 YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGA----PCTAIREVSLLKDLK- 58 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 H N+V L D+ T ++ +TLVFE++D+DL+ YLD + +K + Q L Sbjct: 59 --HANIVTLHDIIHTEKS-----LTLVFEYLDKDLKQYLDDCGNI-INMHNVKLFLFQLL 110 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY-QMALTPVVVTLWYRAPE 184 RGL + H ++HRDLKP+N+L+ G +KLADFGLAR S VVTLWYR P+ Sbjct: 111 RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPD 170 Query: 185 VLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 +LL ST Y+T +DMW VGCIF EM +PLF G++ +QL IF ++G P E+ WP +S Sbjct: 171 ILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILS 230 Query: 244 ---LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 +P + S P ++ GA LL ++L F RISA A++H + Sbjct: 231 NEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >3GC0-A nrPDB Length = 329 Score = 199 bits (507), Expect = 8e-52, Method: Compositional matrix adjust. Identities = 118/311 (37%), Positives = 184/311 (59%), Gaps = 23/311 (7%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 + RY + ++G G YG VYKA D + VA+K +R+ + G +P + +REV+LL+ Sbjct: 32 SIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEEEG---VPGTAIREVSLLK 88 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 L+ H N++ L V + ++ L+FE+ + DL+ Y+DK P + IK + Sbjct: 89 ELQ---HRNIIELKSVIHHNH-----RLHLIFEYAENDLKKYMDKNPDVSM--RVIKSFL 138 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGG-----TVKLADFGLARIYSYQM-ALTPVV 175 Q + G++F H+ +HRDLKP+N+L++ +K+ DFGLAR + + T + Sbjct: 139 YQLINGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEI 198 Query: 176 VTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 +TLWYR PE+LL S Y+T VD+WS+ CI+AEM + PLF G+SE DQL KIF+++GLP Sbjct: 199 ITLWYRPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPD 258 Query: 235 EDDWPRDVSLP--RGAFPP-RGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 + WP +LP + +FP RG + + +++ G LL ML +P KRISA AL+ Sbjct: 259 DTTWPGVTALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALE 318 Query: 292 HSYLHKDEGNP 302 H Y ++ +P Sbjct: 319 HPYFSHNDFDP 329 >1UA2-A nrPDB Length = 346 Score = 193 bits (491), Expect = 6e-50, Method: Compositional matrix adjust. Identities = 112/300 (37%), Positives = 166/300 (55%), Gaps = 12/300 (4%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 RYE + +G G + TVYKARD ++ VA+K +++ + G+ + +RE+ LL+ L Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 HPN++ L+D + ++LVF+ ++ DL + P+ IK M Sbjct: 70 S---HPNIIGLLDAFG-----HKSNISLVFDFMETDLEVIIKDNSLVLTPSH-IKAYMLM 120 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-SYQMALTPVVVTLWYRA 182 L+GL++LH + I+HRDLKP N+L+ G +KLADFGLA+ + S A T VVT WYRA Sbjct: 121 TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA 180 Query: 183 PEVLLQS-TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 PE+L + Y VDMW+VGCI AE+ R P G+S+ DQL +IF+ +G P E+ WP Sbjct: 181 PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM 240 Query: 242 VSLPRG-AFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 300 SLP F P+ + + L+ + FNP RI+A +AL+ Y G Sbjct: 241 CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG 300 >5EFQ-A nrPDB Length = 347 Score = 189 bits (480), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 113/305 (37%), Positives = 162/305 (53%), Gaps = 18/305 (5%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 +++ + IG G YG VYKARD +G VALK VR+ N G PI+ +RE+ +LR Sbjct: 9 CVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEG---FPITAIREIKILR 65 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIK-----VTLVFEHVDQDLRTYLDKAPPPGLPAET 116 +L H +++ + ++ + K LVFE++D DL L+ Sbjct: 66 QLT---HQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLV-HFNENH 121 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA--LTPV 174 IK MRQ + GLD+ H +HRD+K NIL+ + G +KLADFGLAR+YS + + T Sbjct: 122 IKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNK 181 Query: 175 VVTLWYRAPEVLLQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 233 V+TLWYR PE+LL TP +D+WS GCI E+F +KP+F N E QL I + G P Sbjct: 182 VITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSP 241 Query: 234 PEDDWPRDVSLPR-GAFPPRGP--RPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRAL 290 WP + LP P+ R ++ + + L ML +P KR +A +AL Sbjct: 242 CPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQAL 301 Query: 291 QHSYL 295 Q +L Sbjct: 302 QCEFL 306 >4NST-A nrPDB Length = 351 Score = 189 bits (479), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 113/305 (37%), Positives = 165/305 (54%), Gaps = 18/305 (5%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 +++ + IG G YG VYKA+D +G VALK VR+ N G PI+ +RE+ +LR Sbjct: 11 CVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEG---FPITAIREIKILR 67 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIK-----VTLVFEHVDQDLRTYLDKAPPPGLPAET 116 +L H +VV + ++ + + K LVFE++D DL L+ + Sbjct: 68 QLI---HRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLV-HFSEDH 123 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA--LTPV 174 IK M+Q + GL++ H +HRD+K NIL+ + G +KLADFGLAR+Y+ + + T Sbjct: 124 IKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNK 183 Query: 175 VVTLWYRAPEVLLQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 233 V+TLWYR PE+LL TP +D+WS GCI E+F +KP+F N E QL I L G P Sbjct: 184 VITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSP 243 Query: 234 PEDDWPRDVSLPR-GAFPPRGP--RPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRAL 290 WP + LP P+ R ++ + + LL MLT +P KR +A + L Sbjct: 244 CPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTL 303 Query: 291 QHSYL 295 Q +L Sbjct: 304 QSDFL 308 >3MIA-A nrPDB Length = 351 Score = 177 bits (449), Expect = 5e-45, Method: Compositional matrix adjust. Identities = 115/310 (37%), Positives = 168/310 (54%), Gaps = 21/310 (6%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 S+YE +A+IG G +G V+KAR +G VALK V + N G PI+ +RE+ +L+ Sbjct: 16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEG---FPITALREIKILQL 72 Query: 63 LEAFEHPNVVRLMDVCATSRT--DR-EIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKD 119 L+ H NVV L+++C T + +R + + LVF+ + DL L +E IK Sbjct: 73 LK---HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSE-IKR 128 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPV----- 174 +M+ L GL ++H N I+HRD+K N+L+T G +KLADFGLAR +S P Sbjct: 129 VMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNR 188 Query: 175 VVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 233 VVTLWYR PE+LL + Y P+D+W GCI AEM+ R P+ GN+E QL I L G Sbjct: 189 VVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSI 248 Query: 234 PEDDWPR--DVSLPRGAFPPRG-PRPVQSVVPEM--EESGAQLLLEMLTFNPHKRISAFR 288 + WP + L +G R V+ + + L+ ++L +P +RI + Sbjct: 249 TPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDD 308 Query: 289 ALQHSYLHKD 298 AL H + D Sbjct: 309 ALNHDFFWSD 318 >6DTL-A nrPDB Length = 364 Score = 176 bits (445), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 108/300 (36%), Positives = 161/300 (53%), Gaps = 13/300 (4%) Query: 2 ATSRYEP-VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 T++Y+P + IG GAYG V A + + VA+K ++ N T+RE+ LL Sbjct: 27 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIK--KIANAFDNKIDAK-RTLREIKLL 83 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 R ++ H N+V + D+ + V + +E +D DL + L E + Sbjct: 84 RHMD---HENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQ--ALSEEHCQYF 138 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY 180 + Q LRGL ++H+ ++HRDLKP N+L+ + +K+ DFGLAR+ S +T VVT WY Sbjct: 139 LYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWY 198 Query: 181 RAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 RAPE+LL S+ Y +D+WSVGCIF E+ RKPLF G QL + +LIG P E++ Sbjct: 199 RAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELE 258 Query: 240 RDVSLPRGAFPPRGPRPVQSVV---PEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 + P P QS+ P + L+ +MLTF+P +RI+ AL H YL+ Sbjct: 259 FLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 318 >5NGU-A nrPDB Length = 381 Score = 173 bits (438), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 105/302 (34%), Positives = 157/302 (51%), Gaps = 19/302 (6%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 RY ++ IG GAYG V A D + VA+K + T+RE+ +L R Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKI----SPFEHQTYCQRTLREIKILLR-- 96 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 F H N++ + D+ ++ V +V + ++ DL L L + I + Q Sbjct: 97 -FRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQ---HLSNDHICYFLYQI 152 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI----YSYQMALTPVVVTLWY 180 LRGL ++H+ ++HRDLKP N+L+ + +K+ DFGLAR+ + + LT V T WY Sbjct: 153 LRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWY 212 Query: 181 RAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 RAPE++L S Y +D+WSVGCI AEM +P+F G DQL I ++G P ++D Sbjct: 213 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 272 Query: 240 RDVSLPRGAF----PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 ++L + P + P + P + LL +MLTFNPHKRI +AL H YL Sbjct: 273 CIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 332 Query: 296 HK 297 + Sbjct: 333 EQ 334 >4ZSG-A nrPDB Length = 347 Score = 171 bits (432), Expect = 5e-43, Method: Compositional matrix adjust. Identities = 109/303 (35%), Positives = 159/303 (52%), Gaps = 19/303 (6%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 YE + IG GAYG V AR +G VA+K ++PN T+RE+ +L+ Sbjct: 9 YEIIETIGNGAYGVVSSARRRLTGQQVAIK--KIPNAFDVVTNAK-RTLRELKILKH--- 62 Query: 66 FEHPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 F+H N++ + D+ + E K V +V + ++ DL + + P L E ++ + Q Sbjct: 63 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQP--LTLEHVRYFLYQL 120 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-----SYQMALTPVVVTLW 179 LRGL ++H+ ++HRDLKP N+LV +K+ DFG+AR +Q +T V T W Sbjct: 121 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 180 Query: 180 YRAPEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP---- 234 YRAPE++L Y +D+WSVGCIF EM R+ LF G + QL I ++G P Sbjct: 181 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 240 Query: 235 EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294 + V + PPR P P ++V P + LL ML F P RISA AL+H + Sbjct: 241 QAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPF 300 Query: 295 LHK 297 L K Sbjct: 301 LAK 303 >4CRL-A nrPDB Length = 406 Score = 169 bits (429), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 119/327 (36%), Positives = 172/327 (52%), Gaps = 51/327 (15%) Query: 10 AEIGVGAYGTVYKARDPHSGHF--VALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 ++G G YG VYKA+ ALK + G G+ +S RE+ALLR L+ Sbjct: 28 CKVGRGTYGHVYKAKRKDGKDDKDYALKQIE-------GTGISMSACREIALLRELK--- 77 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQDL-------RTYLDKAPPPGLPAETIKDL 120 HPNV+ L V S DR KV L+F++ + DL R P LP +K L Sbjct: 78 HPNVISLQKVF-LSHADR--KVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSL 134 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVT----SGGTVKLADFGLARIYSYQMA----LT 172 + Q L G+ +LHAN ++HRDLKP NILV G VK+AD G AR+++ + L Sbjct: 135 LYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLD 194 Query: 173 PVVVTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSE---------ADQ 222 PVVVT WYRAPE+LL + Y +D+W++GCIFAE+ +P+F E DQ Sbjct: 195 PVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQ 254 Query: 223 LGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQ----SVVPEMEESGAQ-------L 271 L +IF+++G P + DW +P + + R S++ ME+ + L Sbjct: 255 LDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHL 314 Query: 272 LLEMLTFNPHKRISAFRALQHSYLHKD 298 L ++LT +P KRI++ +A+Q Y +D Sbjct: 315 LQKLLTMDPIKRITSEQAMQDPYFLED 341 >4IC8-A nrPDB Length = 442 Score = 169 bits (428), Expect = 1e-42, Method: Compositional matrix adjust. Identities = 108/303 (35%), Positives = 159/303 (52%), Gaps = 19/303 (6%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 YE + IG GAYG V AR +G VA+K ++PN + + R + L+ L+ Sbjct: 57 YEIIETIGNGAYGVVSSARRRLTGQQVAIK--KIPNAFD----VVTNAKRTLRELKILKH 110 Query: 66 FEHPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 F+H N++ + D+ + E K V +V + ++ DL + + P L E ++ + Q Sbjct: 111 FKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQP--LTLEHVRYFLYQL 168 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-----SYQMALTPVVVTLW 179 LRGL ++H+ ++HRDLKP N+LV +K+ DFG+AR +Q +T V T W Sbjct: 169 LRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 228 Query: 180 YRAPEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP---- 234 YRAPE++L Y +D+WSVGCIF EM R+ LF G + QL I ++G P Sbjct: 229 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVI 288 Query: 235 EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294 + V + PPR P P ++V P + LL ML F P RISA AL+H + Sbjct: 289 QAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPF 348 Query: 295 LHK 297 L K Sbjct: 349 LAK 351 >2F9G-A nrPDB Length = 353 Score = 167 bits (424), Expect = 3e-42, Method: Compositional matrix adjust. Identities = 106/321 (33%), Positives = 163/321 (50%), Gaps = 30/321 (9%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 +S ++ + +G GAYG V A +G VA+K + + P+ +R + ++ Sbjct: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEPFDK-------PLFALRTLREIKI 62 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L+ F+H N++ + ++ + +V ++ E + DL + L + I+ + Sbjct: 63 LKHFKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQ---MLSDDHIQYFIY 119 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS-----------YQMAL 171 Q LR + LH + ++HRDLKP N+L+ S +K+ DFGLARI Q + Sbjct: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 Query: 172 TPVVVTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLI 230 T V T WYRAPEV+L S Y+ +D+WS GCI AE+F R+P+F G QL IF +I Sbjct: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 Query: 231 GLPPEDDWPRDVSLPRG-----AFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 G P D+ R + PR + P P++ + P + G LL ML F+P KRI+ Sbjct: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 Query: 286 AFRALQHSYL---HKDEGNPE 303 A AL+H YL H PE Sbjct: 300 AKEALEHPYLQTYHDPNDEPE 320 >4QTB-A nrPDB Length = 380 Score = 167 bits (423), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 105/302 (34%), Positives = 154/302 (50%), Gaps = 19/302 (6%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 RY + IG GAYG V A D VA+K + T+RE+ +L R Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI----SPFEHQTYCQRTLREIQILLR-- 95 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 F H NV+ + D+ S + V +V + ++ DL L L + I + Q Sbjct: 96 -FRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQ---QLSNDHICYFLYQI 151 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI----YSYQMALTPVVVTLWY 180 LRGL ++H+ ++HRDLKP N+L+ + +K+ DFGLARI + + LT V T WY Sbjct: 152 LRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWY 211 Query: 181 RAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 RAPE++L S Y +D+WSVGCI AEM +P+F G DQL I ++G P ++D Sbjct: 212 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 271 Query: 240 RDVSLPR----GAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 +++ + P + + P+ + LL MLTFNP+KRI+ AL H YL Sbjct: 272 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 331 Query: 296 HK 297 + Sbjct: 332 EQ 333 >3N9X-A nrPDB Length = 432 Score = 164 bits (416), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 116/341 (34%), Positives = 162/341 (47%), Gaps = 66/341 (19%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 IG G+YG VY A D ++ VA+K V N +RE+ +L RL++ + Sbjct: 34 IGRGSYGYVYLAYDKNTEKNVAIKKV---NRMFEDLIDCKRILREITILNRLKS---DYI 87 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFL 131 +RL D+ + ++ +V E D DL+ P L E IK ++ L G +F+ Sbjct: 88 IRLYDLIIPDDLLKFDELYIVLEIADSDLKKLF--KTPIFLTEEHIKTILYNLLLGENFI 145 Query: 132 HANCIVHRDLKPENILVTSGGTVKLADFGLARIY-----------------------SYQ 168 H + I+HRDLKP N L+ +VK+ DFGLAR + + Sbjct: 146 HESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEPGPHNKNLK 205 Query: 169 MALTPVVVTLWYRAPE-VLLQSTYATPVDMWSVGCIFAEMF-----------RRKPLFCG 216 LT VVT WYRAPE +LLQ Y +D+WS GCIFAE+ R PLF G Sbjct: 206 KQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPTNRFPLFPG 265 Query: 217 N-----------------SEADQLGKIFDLIGLPPEDDWPRDVSLPR-----GAFPPRGP 254 + S DQL IF++IG P EDD ++++ P FP R P Sbjct: 266 SSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDL-KNINKPEVIKYIKLFPHRKP 324 Query: 255 RPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 ++ P + + G LL ML FNP+KRI+ +AL H YL Sbjct: 325 INLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYL 365 >3FI2-A nrPDB Length = 353 Score = 159 bits (403), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 112/309 (36%), Positives = 154/309 (49%), Gaps = 26/309 (8%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 RY+ + IG GA G V A D VA+K + P RE+ L++ Sbjct: 24 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAK---RAYRELVLMK-- 78 Query: 64 EAFEHPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 H N++ L++V +T E + V LV E +D +L + L E + L+ Sbjct: 79 -CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME----LDHERMSYLLY 133 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 Q L G+ LH+ I+HRDLKP NI+V S T+K+ DFGLAR +TP VVT +YRA Sbjct: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRA 193 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP-PE------ 235 PEV+L Y VD+WSVGCI EM R K LF G DQ K+ + +G P PE Sbjct: 194 PEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ 253 Query: 236 -------DDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQ-LLLEMLTFNPHKRISAF 287 ++ P+ L P P S +++ S A+ LL +ML +P KRIS Sbjct: 254 PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD 313 Query: 288 RALQHSYLH 296 ALQH Y++ Sbjct: 314 DALQHPYIN 322 >1JNK-A nrPDB Length = 423 Score = 159 bits (402), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 112/308 (36%), Positives = 154/308 (50%), Gaps = 26/308 (8%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 RY+ + IG GA G V A D VA+K + P RE+ L++ Sbjct: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAK---RAYRELVLMK--- 116 Query: 65 AFEHPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 H N++ L++V +T E + V LV E +D +L + L E + L+ Q Sbjct: 117 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME----LDHERMSYLLYQ 172 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183 L G+ LH+ I+HRDLKP NI+V S T+K+ DFGLAR +TP VVT +YRAP Sbjct: 173 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAP 232 Query: 184 EVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP-PE------- 235 EV+L Y VD+WSVGCI EM R K LF G DQ K+ + +G P PE Sbjct: 233 EVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP 292 Query: 236 ------DDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQ-LLLEMLTFNPHKRISAFR 288 ++ P+ L P P S +++ S A+ LL +ML +P KRIS Sbjct: 293 TVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDD 352 Query: 289 ALQHSYLH 296 ALQH Y++ Sbjct: 353 ALQHPYIN 360 >5Z33-A nrPDB Length = 425 Score = 157 bits (398), Expect = 5e-39, Method: Compositional matrix adjust. Identities = 104/307 (33%), Positives = 149/307 (48%), Gaps = 20/307 (6%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + RY E+G GAYG V A + + VA+K V L +RE+ LL Sbjct: 28 IVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKV---TNVFSKKILAKRALREIKLL 84 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 + H N+ L D+ R D + L E ++ DL + P L + Sbjct: 85 QHFRG--HRNITCLYDM-DIPRPDNFNETYLYEELMECDLAAIIRSGQP--LTDAHFQSF 139 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ-----MALTPVV 175 + Q L GL ++H+ ++HRDLKP N+LV + +K+ DFGLAR +S +T V Sbjct: 140 IYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYV 199 Query: 176 VTLWYRAPEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 T WYRAPE++L +Y +D+WSVGCI AE+ +P F G DQL +I ++G P Sbjct: 200 ATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPN 259 Query: 235 EDDWPRDVSLPRGA-----FPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 E+ R + PR P +P ++ P LL ML F+P RIS +A Sbjct: 260 EETLSR-IGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQA 318 Query: 290 LQHSYLH 296 L+H YLH Sbjct: 319 LEHPYLH 325 >4BBM-A nrPDB Length = 331 Score = 157 bits (396), Expect = 7e-39, Method: Compositional matrix adjust. Identities = 102/305 (33%), Positives = 154/305 (50%), Gaps = 22/305 (7%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 + +YE + +G G+YG V K R+ +G VA+K + + +RE+ LL+ Sbjct: 23 SMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLESDDDKMVKKI---AMREIKLLK 79 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAP--PPGLPAETIKD 119 +L H N+V L++VC + + LVFE VD T LD P GL + ++ Sbjct: 80 QLR---HENLVNLLEVCKKKK-----RWYLVFEFVDH---TILDDLELFPNGLDYQVVQK 128 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY-QMALTPVVVTL 178 + Q + G+ F H++ I+HRD+KPENILV+ G VKL DFG AR + V T Sbjct: 129 YLFQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATR 188 Query: 179 WYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG--LPPE 235 WYRAPE+L+ Y VD+W++GC+ EMF +PLF G+S+ DQL I +G +P Sbjct: 189 WYRAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRH 248 Query: 236 DDWPRDVSLPRGAFPP--RGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHS 293 + + G P + P++ P++ E L + L +P KR L H Sbjct: 249 QELFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHD 308 Query: 294 YLHKD 298 + D Sbjct: 309 FFQMD 313 >3E7O-A nrPDB Length = 360 Score = 155 bits (393), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 110/307 (35%), Positives = 155/307 (50%), Gaps = 26/307 (8%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 RY+ + IG GA G V A D G VA+K + P RE+ LL+ Sbjct: 23 RYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAK---RAYRELVLLK--- 76 Query: 65 AFEHPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 H N++ L++V +T E + V LV E +D +L + L E + L+ Q Sbjct: 77 CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME----LDHERMSYLLYQ 132 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183 L G+ LH+ I+HRDLKP NI+V S T+K+ DFGLAR S +TP VVT +YRAP Sbjct: 133 MLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYVVTRYYRAP 192 Query: 184 EVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP---- 239 EV+L Y VD+WSVGCI E+ + +F G DQ K+ + +G P + Sbjct: 193 EVILGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQP 252 Query: 240 --RDVSLPRGAFP--------PRGPRPVQSVVPEMEESGAQ-LLLEMLTFNPHKRISAFR 288 R+ R A+P P P +S +++ S A+ LL +ML +P KRIS Sbjct: 253 TVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDE 312 Query: 289 ALQHSYL 295 AL+H Y+ Sbjct: 313 ALRHPYI 319 >4AGU-A nrPDB Length = 311 Score = 155 bits (391), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 99/304 (32%), Positives = 157/304 (51%), Gaps = 30/304 (9%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVAL--LR 61 +YE + +IG G+YG V+K R+ +G VA+K ++++AL +R Sbjct: 3 EKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDD--------PVIKKIALREIR 54 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 L+ +HPN+V L++V R ++ LVFE+ D + LD+ G+P +K + Sbjct: 55 MLKQLKHPNLVNLLEVFRRKR-----RLHLVFEYCDHTVLHELDRYQR-GVPEHLVKSIT 108 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY-QMALTPVVVTLWY 180 Q L+ ++F H + +HRD+KPENIL+T +KL DFG AR+ + V T WY Sbjct: 109 WQTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWY 168 Query: 181 RAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG-LPPE--- 235 R+PE+L+ T Y PVD+W++GC+FAE+ PL+ G S+ DQL I +G L P Sbjct: 169 RSPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQ 228 Query: 236 ----DDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 + + V +P P P++ P + LL L +P +R++ + L Sbjct: 229 VFSTNQYFSGVKIP----DPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLH 284 Query: 292 HSYL 295 H Y Sbjct: 285 HPYF 288 >3ZDU-A nrPDB Length = 325 Score = 154 bits (390), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 103/309 (33%), Positives = 162/309 (52%), Gaps = 39/309 (12%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVAL--LRRL 63 YE + ++G G+YGTV K + ++G VA+K P +V ++A+ ++ L Sbjct: 5 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFY---------ERPEQSVNKIAMREIKFL 55 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPP--PGLPAETIKDLM 121 + F H N+V L++V + K+ LVFE +D T LD+ GL ++ ++ + Sbjct: 56 KQFHHENLVNLIEVFRQKK-----KIHLVFEFIDH---TVLDELQHYCHGLESKRLRKYL 107 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-------IYSYQMALTPV 174 Q LR +D+LH+N I+HRD+KPENILV+ G KL DFG AR IY ++A Sbjct: 108 FQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVA---- 163 Query: 175 VVTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG-L 232 T WYRAPE++L+ T Y PVD+W++GC+ EM P +S+ D L KI +G L Sbjct: 164 --TRWYRAPELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNL 221 Query: 233 PP--EDDWPRDVSLPRGAFPP-RGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 P ++ + + P + P+ + P++ A ++ L +P RIS+ Sbjct: 222 SPHLQNIFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDL 281 Query: 290 LQHSYLHKD 298 L H Y +D Sbjct: 282 LHHEYFTRD 290 >2I6L-A nrPDB Length = 320 Score = 153 bits (387), Expect = 8e-38, Method: Compositional matrix adjust. Identities = 102/312 (32%), Positives = 163/312 (52%), Gaps = 33/312 (10%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 SRY + +G G G V+ A D VA+K + + + L RE+ ++RRL Sbjct: 11 SRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHAL-----REIKIIRRL 65 Query: 64 EAFEHPNVVRLMDVCATSRTD--------REIK-VTLVFEHVDQDLRTYLDKAPPPGLPA 114 + H N+V++ ++ S + E+ V +V E+++ DL L++ P L Sbjct: 66 D---HDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGP---LLE 119 Query: 115 ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTV-KLADFGLARI----YSYQM 169 E + M Q LRGL ++H+ ++HRDLKP N+ + + V K+ DFGLARI YS++ Sbjct: 120 EHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKG 179 Query: 170 ALTPVVVTLWYRAPEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD 228 L+ +VT WYR+P +LL + Y +DMW+ GCIFAEM K LF G E +Q+ I + Sbjct: 180 HLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILE 239 Query: 229 LIGLPPEDDWPRDVS-----LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKR 283 I + E+D +S + P +P+ ++P + L ++LTF+P R Sbjct: 240 SIPVVHEEDRQELLSVIPVYIRNDMTEPH--KPLTQLLPGISREAVDFLEQILTFSPMDR 297 Query: 284 ISAFRALQHSYL 295 ++A AL H Y+ Sbjct: 298 LTAEEALSHPYM 309 >3NIE-A nrPDB Length = 429 Score = 152 bits (385), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 113/350 (32%), Positives = 157/350 (44%), Gaps = 67/350 (19%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 YE IG G+YG VY A D ++ VA+K V N +RE+ +L RL+ Sbjct: 29 NYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKV---NRMFEDLIDCKRILREITILNRLK 85 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 + ++RL D+ + ++ +V E D DL+ P L + +K ++ Sbjct: 86 S---DYIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLF--KTPIFLTEQHVKTILYNL 140 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS------------------ 166 L G F+H + I+HRDLKP N L+ +VK+ DFGLAR + Sbjct: 141 LLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEENE 200 Query: 167 --------YQMALTPVVVTLWYRAPE-VLLQSTYATPVDMWSVGCIFAEMF--------- 208 + LT VVT WYRAPE +LLQ Y +D+WS GCIFAE+ Sbjct: 201 EPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHINN 260 Query: 209 --RRKPLFCGN-----------------SEADQLGKIFDLIGLPPEDDW----PRDVSLP 245 R PLF G+ S DQL IF++IG PPE+D ++V Sbjct: 261 PTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIKY 320 Query: 246 RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 FP R + + + G LL ML FN KRI+ +AL H YL Sbjct: 321 IKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYL 370 >4BGQ-A nrPDB Length = 304 Score = 152 bits (383), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 90/245 (36%), Positives = 134/245 (54%), Gaps = 14/245 (5%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 +++E + +G GAYG V K R + VA+K + + +T+RE+ +LR L Sbjct: 12 NKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFK---DSEENEEVKETTLRELKMLRTL 68 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 + N+V L + R K+ LVFE+V++++ L++ P G+P E +K + Q Sbjct: 69 K---QENIVELKEAFR-----RRGKLYLVFEYVEKNMLELLEEMPN-GVPPEKVKSYIYQ 119 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS--YQMALTPVVVTLWYR 181 ++ + + H N IVHRD+KPEN+L++ +KL DFG AR S V T WYR Sbjct: 120 LIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRWYR 179 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 +PE+LL + Y VDMWSVGCI E+ +PLF G SE DQL I ++G P + Sbjct: 180 SPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLF 239 Query: 242 VSLPR 246 S PR Sbjct: 240 YSNPR 244 >3OZ6-A nrPDB Length = 388 Score = 150 bits (380), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 105/341 (30%), Positives = 162/341 (47%), Gaps = 68/341 (19%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 +YE V ++G GAYG V+K+ D +G VA+K + T RE+ +L L Sbjct: 10 KYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQ---RTFREIMILTELS 66 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 H N+V L++V R D + V LVF++++ DL + + + + + Q Sbjct: 67 G--HENIVNLLNVL---RADNDRDVYLVFDYMETDLHAVIRANILEPVHKQYV---VYQL 118 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY------------------- 165 ++ + +LH+ ++HRD+KP NIL+ + VK+ADFGL+R + Sbjct: 119 IKVIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTE 178 Query: 166 ---SYQMALTPVVVTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEAD 221 Q LT V T WYRAPE+LL ST Y +DMWS+GCI E+ KP+F G+S + Sbjct: 179 NFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMN 238 Query: 222 QLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEME---------------- 265 QL +I +I P +D P ++S+ ++E Sbjct: 239 QLERIIGVIDFPSNED-------VESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNL 291 Query: 266 -----------ESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 E LL ++L FNP+KRISA AL+H ++ Sbjct: 292 LLKINPKADCNEEALDLLDKLLQFNPNKRISANDALKHPFV 332 >1CM8-A nrPDB Length = 367 Score = 150 bits (379), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 108/307 (35%), Positives = 146/307 (47%), Gaps = 20/307 (6%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y + +G GAYG V A D +G VA+K + P + R LR L+ Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQS------ELFAKRAYRELRLLKH 80 Query: 66 FEHPNVVRLMDVCATSRT-DREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 H NV+ L+DV T D LV + DL + L + I+ L+ Q Sbjct: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEK---LGEDRIQFLVYQM 137 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 L+GL ++HA I+HRDLKP N+ V +K+ DFGLAR +M T VVT WYRAPE Sbjct: 138 LKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEM--TGYVVTRWYRAPE 195 Query: 185 VLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR--- 240 V+L Y VD+WSVGCI AEM K LF G+ DQL +I + G PP + R Sbjct: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 Query: 241 -DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY---LH 296 + P + S++ LL +ML + +R++A AL H Y LH Sbjct: 256 DEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLH 315 Query: 297 KDEGNPE 303 E P+ Sbjct: 316 DTEDEPQ 322 >3GC9-A nrPDB Length = 370 Score = 149 bits (377), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 107/302 (35%), Positives = 150/302 (49%), Gaps = 22/302 (7%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G GAYG+V A D VA+K + P I R LR L+ +H NV Sbjct: 36 VGSGAYGSVCSAYDARLRQKVAVKKLSRPFQS------LIHARRTYRELRLLKHLKHENV 89 Query: 72 VRLMDVC--ATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 + L+DV ATS D +V LV + DL + L E ++ L+ Q LRGL Sbjct: 90 IGLLDVFTPATSIEDFS-EVYLVTTLMGADLNNIVKSQ---ALSDEHVQFLVYQLLRGLK 145 Query: 130 FLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQS 189 ++H+ I+HRDLKP N+ V +++ DFGLAR +M T V T WYRAPE++L Sbjct: 146 YIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQADEEM--TGYVATRWYRAPEIMLNW 203 Query: 190 T-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGA 248 Y VD+WSVGCI AE+ + K LF G+ DQL +I +++G P + + S Sbjct: 204 MHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHART 263 Query: 249 F----PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL---HKDEGN 301 + PP + + S+ LL ML + +R+SA AL H+Y H E Sbjct: 264 YIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDE 323 Query: 302 PE 303 PE Sbjct: 324 PE 325 >4O2Z-A nrPDB Length = 377 Score = 149 bits (377), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 104/308 (33%), Positives = 156/308 (50%), Gaps = 17/308 (5%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 S+Y + +G+GAYG D +G V++K R G +RE+ ++R Sbjct: 45 SKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDGK---RVLREIDMMR-- 99 Query: 64 EAFEHPNVVRLMDVCATSRTDREI--KVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 F H N++ ++++ + + V +V +D D+ L L ++ + Sbjct: 100 -FFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQV--LEESHMQYFV 156 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-LTPVVVTLWY 180 Q LRGL +LH+ + HRDLKP N++ +K+ DFGL+R + LT V+T WY Sbjct: 157 YQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWY 216 Query: 181 RAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 R PE+LL++T Y+T VD+WSVGCIFAEM+ RKP+F G + DQL I IG PP Sbjct: 217 RPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVE 276 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEM--EESGAQLLLEMLTFNPHKRISAFRALQHSY--- 294 +L + P G + +VP + G L +M T +P KR +A L H Y Sbjct: 277 HREALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAH 336 Query: 295 LHKDEGNP 302 LH +E P Sbjct: 337 LHDEEDEP 344 >4EWQ-A nrPDB Length = 383 Score = 149 bits (375), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 106/304 (34%), Positives = 152/304 (50%), Gaps = 31/304 (10%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 RY+ ++ +G GAYG+V A D +G VA+K + P I R LR L+ Sbjct: 46 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQS------IIHAKRTYRELRLLK 99 Query: 65 AFEHPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 +H NV+ L+DV +R+ E V LV + DL + L + ++ L+ Q Sbjct: 100 HMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV---KCQKLTDDHVQFLIYQ 156 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183 LRGL ++H+ I+HRDLKP N+ V +K+ DFGLAR +M T V T WYRAP Sbjct: 157 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM--TGYVATRWYRAP 214 Query: 184 EVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 E++L Y VD+WSVGCI AE+ + LF G DQL I L+G P + Sbjct: 215 EIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAE------ 268 Query: 243 SLPRGAFPPRGPRPVQSV--VPEMEES---------GAQLLLEMLTFNPHKRISAFRALQ 291 L + +QS+ +P+M + LL +ML + KRI+A +AL Sbjct: 269 -LLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA 327 Query: 292 HSYL 295 H+Y Sbjct: 328 HAYF 331 >3RP9-A nrPDB Length = 458 Score = 147 bits (371), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 113/356 (31%), Positives = 155/356 (43%), Gaps = 74/356 (20%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSV-RVPNGGGGGGGLPISTVREVALLRRL 63 RYE IG G+YG V +A D VA+K + RV + +RE+A+L RL Sbjct: 54 RYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKILRVFEDLIDCKRI----LREIAILNRL 109 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 H +VV+++D+ ++ ++ +V E D D + P L IK L+ Sbjct: 110 N---HDHVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLF--RTPVYLTELHIKTLLYN 164 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY---------------- 167 L G+ ++H+ I+HRDLKP N LV +VK+ DFGLAR Y Sbjct: 165 LLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDD 224 Query: 168 ------------QMALTPVVVTLWYRAPE-VLLQSTYATPVDMWSVGCIFAEMFR----- 209 + LT VVT WYRAPE +LLQ Y +D+WS+GCIFAE+ Sbjct: 225 MNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKEN 284 Query: 210 ------RKPLFCGNS--------------------EADQLGKIFDLIGLPPEDDW----P 239 R PLF G+S DQL IF+++G P E+D Sbjct: 285 VAYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEK 344 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 D FP R + P LL ML FNP+KRI+ L H + Sbjct: 345 EDAKRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFF 400 >4MYG-A nrPDB Length = 372 Score = 147 bits (370), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 104/289 (35%), Positives = 146/289 (50%), Gaps = 16/289 (5%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G GAYG+V A D SG VA+K + P RE+ LL+ ++ H NV Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRP---FQSEIFAKRAYRELLLLKHMQ---HENV 104 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFL 131 + L+DV + + R F V ++T L K E I+ L+ Q L+GL ++ Sbjct: 105 IGLLDVFTPASSLRNF---YDFYLVMPFMQTDLQKIMGMEFSEEKIQYLVYQMLKGLKYI 161 Query: 132 HANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQST- 190 H+ +VHRDLKP N+ V +K+ DFGLAR +M T VVT WYRAPEV+L Sbjct: 162 HSAGVVHRDLKPGNLAVNEDCELKILDFGLARHADAEM--TGYVVTRWYRAPEVILSWMH 219 Query: 191 YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFP 250 Y VD+WSVGCI AEM K LF G DQL +I + G+P + + ++ Sbjct: 220 YNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSYI 279 Query: 251 ---PRGPRP-VQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 P+ PR + P A LL +ML + KR++A +AL H + Sbjct: 280 QSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFF 328 >3OHT-A nrPDB Length = 389 Score = 147 bits (370), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 107/308 (34%), Positives = 148/308 (48%), Gaps = 20/308 (6%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 RY+ ++ +G GAYG+V + D SG +A+K + P I R LR L+ Sbjct: 52 RYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQS------IIHAKRTYRELRLLK 105 Query: 65 AFEHPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 +H NV+ L+DV + + E V LV + DL + L + ++ L+ Q Sbjct: 106 HMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIVKCQ---KLTDDHVQFLIYQ 162 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183 LRGL ++H+ I+HRDLKP N+ V +K+ DFGLAR +M T V T WYRAP Sbjct: 163 ILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEM--TGYVATRWYRAP 220 Query: 184 EVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 E++L Y VD+WSVGCI AE+ + LF G +QL +I L G PP R Sbjct: 221 EIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRMP 280 Query: 243 SLPR----GAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL--- 295 S + P R V LL +ML + KRI+A AL H Y Sbjct: 281 SHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFSQY 340 Query: 296 HKDEGNPE 303 H + PE Sbjct: 341 HDPDDEPE 348 >2XS0-A nrPDB Length = 386 Score = 147 bits (370), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 105/309 (33%), Positives = 150/309 (48%), Gaps = 26/309 (8%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 RY+ + IG GA G V A D VA+K + P RE+ L++ Sbjct: 26 KRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAK---RAYRELVLMK-- 80 Query: 64 EAFEHPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 H N++ L++V ++ E + V +V E +D +L + L E + L+ Sbjct: 81 -CVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME----LDHERMSYLLY 135 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 Q L G+ LH+ I+HRDLKP NI+V S T+K+ DFGLAR + P VVT +YRA Sbjct: 136 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFVVTRYYRA 195 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP-PE------ 235 PEV+L Y VD+WSVGCI EM + LF G DQ K+ + +G P PE Sbjct: 196 PEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQ 255 Query: 236 -------DDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQ-LLLEMLTFNPHKRISAF 287 ++ P+ P P S +++ S A+ LL +ML + KRIS Sbjct: 256 PTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVD 315 Query: 288 RALQHSYLH 296 ALQH Y++ Sbjct: 316 EALQHPYIN 324 >5AWM-A nrPDB Length = 394 Score = 146 bits (369), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 106/314 (33%), Positives = 148/314 (47%), Gaps = 35/314 (11%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 SRY + IG GA G V A D + VA+K + P RE L++ + Sbjct: 44 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHAK---RAYREFKLMKLV 100 Query: 64 EAFEHPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 H N++ L++ R E + V LV E +D +L + L + + L+ Sbjct: 101 N---HKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQM----DLDHDRMSYLLY 153 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 Q L G+ LH+ I+HRDLKP NI+V + T+K+ DFGLAR +TP VVT +YRA Sbjct: 154 QMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRA 213 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP-------- 234 PEV+L Y VD+WSVGCI EM R LF G DQ KI + +G P Sbjct: 214 PEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 273 Query: 235 ------EDDWPR------DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHK 282 ++ PR D P G FP + + + LL +ML +P + Sbjct: 274 PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASD----ARNLLSKMLVIDPEQ 329 Query: 283 RISAFRALQHSYLH 296 RIS AL+H Y++ Sbjct: 330 RISVDEALKHEYIN 343 >4QNY-A nrPDB Length = 354 Score = 144 bits (363), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 94/293 (32%), Positives = 146/293 (49%), Gaps = 14/293 (4%) Query: 12 IGVGAYGTVYKARDPHSGH-FVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 IG G+YG V +ARD S + VA+K RV L +RE+ LL F N Sbjct: 28 IGAGSYGVVIRARDTKSDNRLVAMK--RVNKEIFEEVILAKRILREIKLLAH---FNDDN 82 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 ++ L ++ + +V + ++ DL+ L L I+ + Q LR L Sbjct: 83 IIGLRNILTPEDPENFDHFYIVMDIMETDLKQVLRSGQE--LTEAHIQFFIYQALRALHI 140 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ-MALTPVVVTLWYRAPEVLLQS 189 +H+ ++HRD+ P NILV + +K+ DFGLA+ + Q +T V WYRAPE++++ Sbjct: 141 IHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVMED 200 Query: 190 T-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR-DVSLPRG 247 Y+ +D+W +GCI E+ +PLF G +QL KI D+IG P E+D S + Sbjct: 201 KDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSSAAQK 260 Query: 248 AFPPRGPRPV---QSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 + RP + P LL ML FNP +RI+ +A++H +L + Sbjct: 261 YLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFLEQ 313 >3PG1-A nrPDB Length = 362 Score = 144 bits (363), Expect = 5e-35, Method: Compositional matrix adjust. Identities = 103/295 (34%), Positives = 142/295 (48%), Gaps = 15/295 (5%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPIST-----VREVALLRRLEAF 66 I G+YG V D G VA+K RV N G + I + R + +R L F Sbjct: 30 ISSGSYGAVCAGVDS-EGIPVAIK--RVFNTVSDGRTVNILSDSFLCKRVLREIRLLNHF 86 Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLR 126 HPN++ L D+ K+ LV E + DL + P + I+ M L Sbjct: 87 HHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQRIVISP-QHIQYFMYHILL 145 Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVL 186 GL LH +VHRDL P NIL+ + + DF LAR + T V WYRAPE++ Sbjct: 146 GLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWYRAPELV 205 Query: 187 LQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD-----WPR 240 +Q + VDMWS GC+ AEMF RK LF G++ +QL KI +++G P +D P Sbjct: 206 MQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVMFSSPS 265 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 R + R +VVP + L+ +ML FNP +RIS +AL+H Y Sbjct: 266 ARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYF 320 >5Y86-A nrPDB Length = 588 Score = 135 bits (339), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 83/232 (35%), Positives = 125/232 (53%), Gaps = 12/232 (5%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 RYE + IG G++G V + D +VALK VR +R + L++ + Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAA---EEIRILEHLKKQD 264 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 NV+ +++ S T R V + FE + DL + K G + ++ + Sbjct: 265 KTGSMNVIHMLE----SFTFRN-HVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSI 319 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGG--TVKLADFGLARIYSYQMALTPVVVTLWYRA 182 L+ LD LH N I+H DLKPENIL+ G + K+ DFG + + YQ T + + +YRA Sbjct: 320 LQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFG-SSCFEYQKLYT-YIQSRFYRA 377 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 PE++L S Y+TP+D+WS GCI AE+ +PLF G E DQL + +L+G+PP Sbjct: 378 PEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPP 429 >3E3P-A nrPDB Length = 360 Score = 130 bits (328), Expect = 5e-31, Method: Compositional matrix adjust. Identities = 100/309 (32%), Positives = 151/309 (48%), Gaps = 32/309 (10%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 R++ G G +GTV ++ +G VA+K V P RE+ +++ L Sbjct: 24 RFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQD---------PRFRNRELQIMQDLA 74 Query: 65 AFEHPNVVRLMDVCAT--SRTDREIKVTLVFEHVDQDL----RTYLDK--APPPGLPAET 116 HPN+V+L T R R+I + +V E+V L R Y + APPP L Sbjct: 75 VLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAPPPIL---- 130 Query: 117 IKDLMRQFLRGLDFLH--ANCIVHRDLKPENILVTSG-GTVKLADFGLARIYSYQMALTP 173 IK + Q +R + LH + + HRD+KP N+LV GT+KL DFG A+ S Sbjct: 131 IKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVA 190 Query: 174 VVVTLWYRAPEVLL-QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGL 232 + + +YRAPE++ Y T VD+WSVGCIFAEM +P+F G++ A QL +I ++G Sbjct: 191 YICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGC 250 Query: 233 PPEDDWPR------DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISA 286 P + + DV L P + + +E+ LL +L + P +R+ Sbjct: 251 PSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEA-YDLLSALLQYLPEERMKP 309 Query: 287 FRALQHSYL 295 + AL H Y Sbjct: 310 YEALCHPYF 318 >5ZTN-A nrPDB Length = 429 Score = 129 bits (323), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 99/327 (30%), Positives = 149/327 (45%), Gaps = 44/327 (13%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 RYE + IG G++G V KA D VALK VR E+ +L L Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKR------FHRQAAEEIRILEHLR 151 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 + N + ++ + I +T FE + +L + K G ++ Sbjct: 152 KQDKDNTMNVIHMLENFTFRNHICMT--FELLSMNLYELIKKNKFQGFSLPLVRKFAHSI 209 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGT--VKLADFGLARIYSYQMALTPVVVTLWYRA 182 L+ LD LH N I+H DLKPENIL+ G +K+ DFG + Y +Q T + + +YRA Sbjct: 210 LQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFG-SSCYEHQRVYT-YIQSRFYRA 267 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPE------- 235 PEV+L + Y P+DMWS+GCI AE+ PL G E DQL + +L+G+P + Sbjct: 268 PEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASK 327 Query: 236 --------DDWPRD---VSLPRGAFPPRGPRPVQSVV---PEMEESGAQL---------- 271 +PR +L G+ G R + + PE E G L Sbjct: 328 RAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLD 387 Query: 272 -LLEMLTFNPHKRISAFRALQHSYLHK 297 L + L ++P R++ +AL+H +L + Sbjct: 388 FLKQCLEWDPAVRMTPGQALRHPWLRR 414 >4E7W-A nrPDB Length = 394 Score = 125 bits (314), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 96/303 (31%), Positives = 147/303 (48%), Gaps = 32/303 (10%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSV----RVPNGGGGGGGLPISTVREVALLR 61 Y IG G++G V++A+ S VA+K V R N RE+ ++R Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN-------------RELQIMR 87 Query: 62 RLEAFEHPNVVRLMDVCATSRTDR-EIKVTLVFEHVDQDL----RTYLDKAPPPGLPAET 116 +HPNVV L ++ + E+ + LV E+V + + R Y +P Sbjct: 88 ---IVKHPNVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQ--TMPMLL 142 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTS-GGTVKLADFGLARIYSYQMALTPVV 175 IK M Q LR L ++H+ I HRD+KP+N+L+ G +KL DFG A+I + Sbjct: 143 IKLYMYQLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYI 202 Query: 176 VTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 + +YRAPE++ +T Y T +D+WS GC+ AE+ + +PLF G S DQL +I ++G P Sbjct: 203 CSRYYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPS 262 Query: 235 -EDDWPRDVSLPRGAFPPRGPRPVQSVV-PEMEESGAQLLLEMLTFNPHKRISAFRALQH 292 E + + FP P P V P L+ +L + P R++A AL H Sbjct: 263 REQIKTMNPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCH 322 Query: 293 SYL 295 + Sbjct: 323 PFF 325 >3EB0-A nrPDB Length = 383 Score = 123 bits (308), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 94/334 (28%), Positives = 154/334 (46%), Gaps = 53/334 (15%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 ++ +Y +G G++G V + D SG ALK V P RE+ +++ Sbjct: 5 SSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQD---------PRYKNRELDIMK 55 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIK--------------------------------- 88 L+ H N+++L+D T+ D E K Sbjct: 56 VLD---HVNIIKLVDYFYTT-GDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNK 111 Query: 89 -VTLVFEHVDQDLRTYLDKAPPPG--LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPEN 145 + ++ E+V L L G +P I + Q R + F+H+ I HRD+KP+N Sbjct: 112 YLNVIMEYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQN 171 Query: 146 ILVTS-GGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATP-VDMWSVGCI 203 +LV S T+KL DFG A+ + + +YRAPE++L +T TP +D+WS+GC+ Sbjct: 172 LLVNSKDNTLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCV 231 Query: 204 FAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR-DVSLPRGAFPPRGPRPVQSVVP 262 F E+ KPLF G + DQL +I ++G P ++ R + FP + + ++P Sbjct: 232 FGELILGKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILP 291 Query: 263 EMEESGA-QLLLEMLTFNPHKRISAFRALQHSYL 295 E S A LL ++L + P RI+ + A+ H + Sbjct: 292 EGTPSLAIDLLEQILRYEPDLRINPYEAMAHPFF 325 >5AIR-A nrPDB Length = 430 Score = 123 bits (308), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 92/303 (30%), Positives = 144/303 (47%), Gaps = 31/303 (10%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSV----RVPNGGGGGGGLPISTVREVALLR 61 Y IG G++G VY+A+ SG VA+K V R N RE+ ++R Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN-------------RELQIMR 112 Query: 62 RLEAFEHPNVVRLMDVCATSRTDR-EIKVTLVFEHVDQDL----RTYLDKAPPPGLPAET 116 +L+ H N+VRL +S + E+ + LV ++V + + R Y LP Sbjct: 113 KLD---HCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHY--SRAKQTLPVIY 167 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTV-KLADFGLARIYSYQMALTPVV 175 +K M Q R L ++H+ I HRD+KP+N+L+ V KL DFG A+ + Sbjct: 168 VKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYI 227 Query: 176 VTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 + +YRAPE++ +T Y + +D+WS GC+ AE+ +P+F G+S DQL +I ++G P Sbjct: 228 CSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPT 287 Query: 235 -EDDWPRDVSLPRGAFPPRGPRPVQSVV-PEMEESGAQLLLEMLTFNPHKRISAFRALQH 292 E + + FP P V P L +L + P R++ A H Sbjct: 288 REQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAH 347 Query: 293 SYL 295 S+ Sbjct: 348 SFF 350 >2WO6-A nrPDB Length = 382 Score = 122 bits (306), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 102/339 (30%), Positives = 150/339 (44%), Gaps = 61/339 (17%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 RYE + IG G++G V KA D +VA+K ++ + EV LL + Sbjct: 55 RYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI------EVRLLELMN 108 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 +H ++ V + LVFE + +L L G+ + +Q Sbjct: 109 --KHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQM 166 Query: 125 LRGLDFLHA--NCIVHRDLKPENILVTS--GGTVKLADFGLA-----RIYSYQMALTPVV 175 L FL I+H DLKPENIL+ + +K+ DFG + RIY Y + Sbjct: 167 CTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQY-------I 219 Query: 176 VTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPE 235 + +YR+PEVLL Y +DMWS+GCI EM +PLF G +E DQ+ KI +++G+PP Sbjct: 220 QSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPA 279 Query: 236 ---DDWPRD----VSLPRGA------------FPPRGPRPVQSVV---------PEMEES 267 D P+ LP G + P G R + +++ ES Sbjct: 280 HILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGES 339 Query: 268 G---------AQLLLEMLTFNPHKRISAFRALQHSYLHK 297 G L+L ML ++P RI + ALQHS+ K Sbjct: 340 GHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKK 378 >3NCG-A nrPDB Length = 486 Score = 111 bits (278), Expect = 3e-25, Method: Compositional matrix adjust. Identities = 88/310 (28%), Positives = 136/310 (43%), Gaps = 67/310 (21%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 RY V +G G++G V K +D + A V+V N + +REV LL++L+ Sbjct: 23 RYNIVCMLGKGSFGEVLKCKDRITQQEYA---VKVINKASAKNKDTSTILREVELLKKLD 79 Query: 65 AFEHPNVVRLMDVCATSRT--------------DREIKVTLVFEHVDQDLRTYLDKAPPP 110 HPN+++L ++ S + D IK EH D A Sbjct: 80 ---HPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEH---------DAAR-- 125 Query: 111 GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGT---VKLADFGLARIYSY 167 +++Q G+ ++H + IVHRDLKPENIL+ S +K+ DFGL+ + Sbjct: 126 ---------IIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQ 176 Query: 168 QMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIF 227 + + T +Y APEV L+ TY D+WS G I + P F G +E D L + Sbjct: 177 NTKMKDRIGTAYYIAPEV-LRGTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKR-- 233 Query: 228 DLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAF 287 V + AF R + + L+ +MLTF+P RI+A Sbjct: 234 --------------VETGKYAFDLPQWRTIS-------DDAKDLIRKMLTFHPSLRITAT 272 Query: 288 RALQHSYLHK 297 + L+H ++ K Sbjct: 273 QCLEHPWIQK 282 >3DFA-A nrPDB Length = 286 Score = 110 bits (274), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 88/310 (28%), Positives = 136/310 (43%), Gaps = 67/310 (21%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 RY V +G G++G V K +D + A V+V N + +REV LL++L+ Sbjct: 23 RYNIVCMLGKGSFGEVLKCKDRITQQEYA---VKVINKASAKNKDTSTILREVELLKKLD 79 Query: 65 AFEHPNVVRLMDVCATSRT--------------DREIKVTLVFEHVDQDLRTYLDKAPPP 110 HPN+++L ++ S + D IK EH D A Sbjct: 80 ---HPNIMKLFEILEDSSSFYIVGELYTGGELFDEIIKRKRFSEH---------DAAR-- 125 Query: 111 GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGT---VKLADFGLARIYSY 167 +++Q G+ ++H + IVHRDLKPENIL+ S +K+ DFGL+ + Sbjct: 126 ---------IIKQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQ 176 Query: 168 QMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIF 227 + + T +Y APEV L+ TY D+WS G I + P F G +E D L + Sbjct: 177 NTKMKDRIGTAYYIAPEV-LRGTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKR-- 233 Query: 228 DLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAF 287 V + AF R + + L+ +MLTF+P RI+A Sbjct: 234 --------------VETGKYAFDLPQWRTIS-------DDAKDLIRKMLTFHPSLRITAT 272 Query: 288 RALQHSYLHK 297 + L+H ++ K Sbjct: 273 QCLEHPWIQK 282 >3LIJ-A nrPDB Length = 494 Score = 108 bits (271), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 84/295 (28%), Positives = 136/295 (46%), Gaps = 43/295 (14%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y+ V ++G GAYG V RD + A+K +R + + EVA+L+ L+ Sbjct: 39 YQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNS---KLLEEVAVLKLLD- 94 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVD--QDLRTYLDKAPPPGLPAETIKDLMRQ 123 HPN+++L D R LV E + + + + A I ++Q Sbjct: 95 --HPNIMKLYDFFEDKRN-----YYLVMECYKGGELFDEIIHRMKFNEVDAAVI---IKQ 144 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTLWY 180 L G+ +LH + IVHRDLKPEN+L+ S +K+ DFGL+ ++ Q + + T +Y Sbjct: 145 VLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTAYY 204 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 APEV L+ Y D+WS+G I + P F G ++ + L K+ Sbjct: 205 IAPEV-LRKKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKV-------------- 249 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 +G + P + E L+ +ML F+ +RISA +AL+H ++ Sbjct: 250 ----EKGKYTFDSPEW-----KNVSEGAKDLIKQMLQFDSQRRISAQQALEHPWI 295 >5XVU-A nrPDB Length = 332 Score = 107 bits (268), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 82/306 (26%), Positives = 146/306 (47%), Gaps = 32/306 (10%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 +RYE + +IG G Y V+ D A+K ++ RE+ +L+ L Sbjct: 31 NRYEIMKKIGRGKYSEVFNGYDTECNRPCAIKVLKP--------VKKKKIKREIKILQNL 82 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMR 122 PN+++L+D+ T +L+FE+++ D +T P + I+ + Sbjct: 83 NG--GPNIIKLLDIVKDPVTKTP---SLIFEYINNIDFKTLY-----PKFTDKDIRYYIY 132 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALTPVVVTLWYR 181 Q L+ LD+ H+ I+HRD+KP NI++ ++L +GLA Y V + +Y+ Sbjct: 133 QILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRVASRYYK 192 Query: 182 APEVLLQ-STYATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 PE+L+ Y +D+WS+GC+ A M F+++P FCG+ DQL KI ++G + Sbjct: 193 GPELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYL 252 Query: 240 RDVSLP--------RGAF--PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 + ++ G + P QS + ++ L+ +ML ++ KRI+ A Sbjct: 253 KKYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEA 312 Query: 290 LQHSYL 295 ++H Y Sbjct: 313 MEHPYF 318 >3HZT-A nrPDB Length = 467 Score = 106 bits (264), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 89/301 (29%), Positives = 137/301 (45%), Gaps = 44/301 (14%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVR---VPNGGGGGGGLPISTVREVAL 59 + RY+ V ++G GAYG V +D +G A+K ++ V G L EVA+ Sbjct: 3 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLD-----EVAV 57 Query: 60 LRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKD 119 L++L+ HPN+++L + R LV E V + + + Sbjct: 58 LKQLD---HPNIMKLYEFFEDKRN-----YYLVME-VYRGGELFDEIILRQKFSEVDAAV 108 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVV 176 +M+Q L G +LH + IVHRDLKPEN+L+ S +K+ DFGL+ + + + Sbjct: 109 IMKQVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLG 168 Query: 177 TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPED 236 T +Y APEV L+ Y D+WS G I + P F G ++ + L ++ Sbjct: 169 TAYYIAPEV-LRKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRV---------- 217 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 +G F P Q + + QL+ MLT+ P KRISA AL H ++ Sbjct: 218 --------EKGKFSFDPPDWTQ-----VSDEAKQLVKLMLTYEPSKRISAEEALNHPWIV 264 Query: 297 K 297 K Sbjct: 265 K 265 >4RGJ-A nrPDB Length = 520 Score = 106 bits (264), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 81/302 (26%), Positives = 138/302 (45%), Gaps = 49/302 (16%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 +Y+ + +G G++G V +RD H+GH A+K + + S +REV LL+ Sbjct: 59 NEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHVKRKTD--KESLLREVELLKM 116 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTL----VFEHVDQDLRTY-LDKAPPPGLPAETI 117 L+ H N+++L + + + +F+ + R Y +D A Sbjct: 117 LD---HINIMKLYEFFEDNNYYYLVSDVYTGGELFDEIISRKRFYEIDAAR--------- 164 Query: 118 KDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGT----VKLADFGLARIYSYQMALTP 173 +++Q L G+ ++H N +VHRDLKPENIL+ + +K+ DFGL+ + Y + Sbjct: 165 --IIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKD 222 Query: 174 VVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 233 + T +Y AP+V L TY D+WS G I + P F G++E D L K+ Sbjct: 223 KIGTAYYIAPDV-LHGTYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKV------- 274 Query: 234 PEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHS 293 G + P+ ++ + L+ +ML + RISA AL+H Sbjct: 275 -----------EAGKYTFDLPQ-----FKKISDKAKDLIKKMLMYTSAVRISARDALEHE 318 Query: 294 YL 295 ++ Sbjct: 319 WI 320 >6O6Q-A nrPDB Length = 335 Score = 106 bits (264), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 80/306 (26%), Positives = 145/306 (47%), Gaps = 37/306 (12%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPIS---TVREVALLRR 62 YE + ++G G Y V+ D V +K ++ P+ RE+++L+ Sbjct: 43 YEILRKLGRGKYSEVFLGIDLEKREKVVIKVLK-----------PVKRKKIKREISILKN 91 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLM 121 L + PN++ ++DV R + L+FEH++ D R+ P I+ M Sbjct: 92 L--VDGPNIIAMLDVV---REPQSKTPGLIFEHINNIDFRSLY-----PTFTDYDIRFYM 141 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGT-VKLADFGLARIYSYQMALTPVVVTLWY 180 + L+ LD+ H+ I+HRD+KP N+++ ++L D+GLA Y V + ++ Sbjct: 142 YELLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYF 201 Query: 181 RAPEVLLQ-STYATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 + PE+L+ Y +DMWS GC+ A M F ++P F G S DQL +I ++G + Sbjct: 202 KGPELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKY 261 Query: 239 PRDVSLPRG-AFPPRGPRPVQSVVPEMEESGAQLLLE--------MLTFNPHKRISAFRA 289 ++ G + G + V M E+ L+ + +L ++ +R++A A Sbjct: 262 LEKYNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEA 321 Query: 290 LQHSYL 295 ++H+Y Sbjct: 322 MKHAYF 327 >3DXN-A nrPDB Length = 287 Score = 105 bits (263), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 89/301 (29%), Positives = 137/301 (45%), Gaps = 44/301 (14%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVR---VPNGGGGGGGLPISTVREVAL 59 + RY+ V ++G GAYG V +D +G A+K ++ V G L EVA+ Sbjct: 20 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTSNSGALLD-----EVAV 74 Query: 60 LRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKD 119 L++L+ HPN+++L + R LV E V + + + Sbjct: 75 LKQLD---HPNIMKLYEFFEDKRN-----YYLVME-VYRGGELFDEIILRQKFSEVDAAV 125 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVV 176 +M+Q L G +LH + IVHRDLKPEN+L+ S +K+ DFGL+ + + + Sbjct: 126 IMKQVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLG 185 Query: 177 TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPED 236 T +Y APEV L+ Y D+WS G I + P F G ++ + L ++ Sbjct: 186 TAYYIAPEV-LRKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRV---------- 234 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 +G F P Q + + QL+ MLT+ P KRISA AL H ++ Sbjct: 235 --------EKGKFSFDPPDWTQ-----VSDEAKQLVKLMLTYEPSKRISAEEALNHPWIV 281 Query: 297 K 297 K Sbjct: 282 K 282 >4IAN-A nrPDB Length = 358 Score = 102 bits (255), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 90/330 (27%), Positives = 142/330 (43%), Gaps = 45/330 (13%) Query: 4 SRYEPVAEIGVGAYGTVYKARD-PHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 RY G G + V +ARD + VA+K +R + + ++E+ L++ Sbjct: 30 KRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR------NNELMQKTGLKELEFLKK 83 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDK-APPPGLPAETIKDLM 121 L + + + + + + LVFE + +LR L K GL + ++ Sbjct: 84 LNDADPDDKFHCLRLFRHFYHKQHL--CLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYS 141 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTV-KLADFGLARIYSYQMALTPVVVTLWY 180 +Q L L I+H D+KP+NILV T+ KL DFG A + +TP +V+ +Y Sbjct: 142 QQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSAS-HVADNDITPYLVSRFY 200 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPE----- 235 RAPE+++ +Y +DMWSVGC E++ K LF G + L DL G P Sbjct: 201 RAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRK 260 Query: 236 ---DDWPRDVSL-----PRGAFPPRGPRPVQSVV----------------PEMEESGAQ- 270 D D +L R V S + PE + Sbjct: 261 GVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQ 320 Query: 271 ---LLLEMLTFNPHKRISAFRALQHSYLHK 297 LL ++L +P KRIS +ALQH+++ + Sbjct: 321 LKDLLDQILMLDPAKRISINQALQHAFIQE 350 >2JD5-A nrPDB Length = 373 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 91/337 (27%), Positives = 151/337 (44%), Gaps = 47/337 (13%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 +RY V ++G G + TV+ A+D + VA+K VR G + E+ LL+R+ Sbjct: 19 ARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVR------GDKVYTEAAEDEIKLLQRV 72 Query: 64 EAFEHP--------NVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAE 115 ++ ++++L+D + + V +VFE + ++L + K G+P Sbjct: 73 NDADNTKEDSMGANHILKLLD-HFNHKGPNGVHVVMVFEVLGENLLALIKKYEHRGIPLI 131 Query: 116 TIKDLMRQFLRGLDFLHANC-IVHRDLKPENILVTSGGT------VKLADFGLARIYSYQ 168 +K + +Q L GLD++H C I+H D+KPEN+L+ + +K+AD G A Y Sbjct: 132 YVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEH 191 Query: 169 MALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLF------CGNSEADQ 222 T + T YR+PEVLL + + D+WS C+ E+ LF + D Sbjct: 192 Y--TNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDDDH 249 Query: 223 LGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGP---------RPVQSVVPEMEESG----- 268 + +I +L+G P R+ R F RG P++ V+ E + Sbjct: 250 IAQIIELLGELPS-YLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAK 308 Query: 269 --AQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 303 + L ML +P KR A + H +L G E Sbjct: 309 EISDFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEE 345 >2W4O-A nrPDB Length = 349 Score = 102 bits (253), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 86/304 (28%), Positives = 141/304 (46%), Gaps = 51/304 (16%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVR-EVALLRRLE 64 +E +E+G GA VY+ + + ALK ++ + VR E+ +L RL Sbjct: 55 FEVESELGRGATSIVYRCKQKGTQKPYALKVLK--------KTVDKKIVRTEIGVLLRLS 106 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAE-TIKDLMRQ 123 HPN+++L ++ T +++LV E V D+ G +E D ++Q Sbjct: 107 ---HPNIIKLKEIFETP-----TEISLVLELVTGG--ELFDRIVEKGYYSERDAADAVKQ 156 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTLWY 180 L + +LH N IVHRDLKPEN+L + +K+ADFGL++I +Q+ + V T Y Sbjct: 157 ILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGY 216 Query: 181 RAPEVLLQSTYATPVDMWSVGCI-FAEMFRRKPLFCGNSEADQLGKIFDL--IGLPPEDD 237 APE+L Y VDMWSVG I + + +P + + +I + + P Sbjct: 217 CAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISP--- 273 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 W +VSL + L+ +++ +P KR++ F+ALQH ++ Sbjct: 274 WWDEVSL----------------------NAKDLVRKLIVLDPKKRLTTFQALQHPWVTG 311 Query: 298 DEGN 301 N Sbjct: 312 KAAN 315 >5JN2-A nrPDB Length = 525 Score = 102 bits (253), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 86/306 (28%), Positives = 137/306 (44%), Gaps = 56/306 (18%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + RY+ +G G++G V +D +G A+K + S +REV LL++ Sbjct: 66 SDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTD--KESLLREVQLLKQ 123 Query: 63 LEAFEHPNVVRLMD---------VCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLP 113 L+ HPN+++L + + T E L E + + + +D A Sbjct: 124 LD---HPNIMKLYEFFEDKGYFYLVGEVYTGGE----LFDEIISRKRFSEVDAAR----- 171 Query: 114 AETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMA 170 ++RQ L G+ ++H N IVHRDLKPEN+L+ S +++ DFGL+ + Sbjct: 172 ------IIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKK 225 Query: 171 LTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLI 230 + + T +Y APEV L TY D+WS G I + P F G +E D L K+ Sbjct: 226 MKDKIGTAYYIAPEV-LHGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKV---- 280 Query: 231 GLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRAL 290 +G + P+ ++ ES L+ +MLT+ P RISA AL Sbjct: 281 --------------EKGKYTFELPQ-----WKKVSESAKDLIRKMLTYVPSMRISARDAL 321 Query: 291 QHSYLH 296 H ++ Sbjct: 322 DHEWIQ 327 >2VN9-A nrPDB Length = 301 Score = 101 bits (252), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 97/307 (31%), Positives = 132/307 (42%), Gaps = 59/307 (19%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 T Y+ E+G GA+ V + +G A K + RE + R Sbjct: 3 TDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQ---KLEREARICRL 59 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-------DQDLRTYLDKAPPPGLPAE 115 L+ HPN+VRL D + E LVF+ V D R Y +A Sbjct: 60 LK---HPNIVRLHDSIS-----EEGFHYLVFDLVTGGELFEDIVAREYYSEADAS----- 106 Query: 116 TIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLA-RIYSYQMAL 171 ++Q L ++ H N IVHRDLKPEN+L+ S G VKLADFGLA + Q A Sbjct: 107 ---HCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAW 163 Query: 172 TPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG 231 T Y +PEVL + Y PVDMW+ G I + L+G Sbjct: 164 FGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYIL---------------------LVG 202 Query: 232 LPP---EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFR 288 PP ED + GA+ P +V PE ++ L+ +MLT NP KRI+A Sbjct: 203 YPPFWDEDQHRLYQQIKAGAYDFPSPE-WDTVTPEAKD----LINKMLTINPAKRITASE 257 Query: 289 ALQHSYL 295 AL+H ++ Sbjct: 258 ALKHPWI 264 >3MA6-A nrPDB Length = 298 Score = 101 bits (252), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 86/306 (28%), Positives = 137/306 (44%), Gaps = 56/306 (18%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + RY+ +G G++G V +D +G A+K + S +REV LL++ Sbjct: 31 SDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQVKQKTD--KESLLREVQLLKQ 88 Query: 63 LEAFEHPNVVRLMD---------VCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLP 113 L+ HPN+++L + + T E L E + + + +D A Sbjct: 89 LD---HPNIMKLYEFFEDKGYFYLVGEVYTGGE----LFDEIISRKRFSEVDAAR----- 136 Query: 114 AETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMA 170 ++RQ L G+ ++H N IVHRDLKPEN+L+ S +++ DFGL+ + Sbjct: 137 ------IIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKK 190 Query: 171 LTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLI 230 + + T +Y APEV L TY D+WS G I + P F G +E D L K+ Sbjct: 191 MKDKIGTAYYIAPEV-LHGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKV---- 245 Query: 231 GLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRAL 290 +G + P+ ++ ES L+ +MLT+ P RISA AL Sbjct: 246 --------------EKGKYTFELPQW-----KKVSESAKDLIRKMLTYVPSMRISARDAL 286 Query: 291 QHSYLH 296 H ++ Sbjct: 287 DHEWIQ 292 >2X7G-A nrPDB Length = 389 Score = 101 bits (252), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 103/369 (27%), Positives = 154/369 (41%), Gaps = 85/369 (23%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 RY + ++G G + TV+ D FVA+K V+ + + E+ LL+ Sbjct: 30 NGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK------SAQHYTETALDEIKLLKC 83 Query: 63 LEAFE--HPN---VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETI 117 + + PN VV+L+D S + I V +VFE + L ++ K+ GLP + Sbjct: 84 VRESDPSDPNKDMVVQLIDDFKISGMNG-IHVCMVFEVLGHHLLKWIIKSNYQGLPVRCV 142 Query: 118 KDLMRQFLRGLDFLHANC-IVHRDLKPENILVT------------------------SGG 152 K ++RQ L+GLD+LH+ C I+H D+KPENIL+ SG Sbjct: 143 KSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGS 202 Query: 153 T-----------------------VKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQS 189 VK+AD G A T + T YR+ EVL+ + Sbjct: 203 AVSTAPAADLLVNPLDPRNADKIRVKIADLGNA--CWVHKHFTEDIQTRQYRSIEVLIGA 260 Query: 190 TYATPVDMWSVGCIFAEMFRRKPLFCGNS------EADQLGKIFDLIGLPPEDDWPRDVS 243 Y+TP D+WS C+ E+ LF +S + D + I +L+G P + Sbjct: 261 GYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPR-HFALSGK 319 Query: 244 LPRGAFPPRG---------PRPVQSVVPEM----EESGAQ---LLLEMLTFNPHKRISAF 287 R F RG P + V+ E E AQ L+ ML P KR SA Sbjct: 320 YSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAG 379 Query: 288 RALQHSYLH 296 L+H +L+ Sbjct: 380 ECLRHPWLN 388 >3Q5I-A nrPDB Length = 504 Score = 100 bits (250), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 86/315 (27%), Positives = 138/315 (43%), Gaps = 60/315 (19%) Query: 6 YEPVAEIGVGAYGTVY--KARDPHSGHFV-ALKSVRVPNGGGGGGGLPISTV-----REV 57 Y V ++G GAYG V K ++ HS + +K + G I E+ Sbjct: 38 YFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEI 97 Query: 58 ALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD--QDLRTYLDKAPPPGLPAE 115 +LL+ L+ HPN+++L DV + LV E + + +++ A Sbjct: 98 SLLKSLD---HPNIIKLFDVFEDKKY-----FYLVTEFYEGGELFEQIINRHKFDECDAA 149 Query: 116 TIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGT---VKLADFGLARIYSYQMALT 172 I M+Q L G+ +LH + IVHRD+KPENIL+ + + +K+ DFGL+ +S L Sbjct: 150 NI---MKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLR 206 Query: 173 PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI------ 226 + T +Y APEV L+ Y D+WS G I + P F G ++ D + K+ Sbjct: 207 DRLGTAYYIAPEV-LKKKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYY 265 Query: 227 FDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISA 286 FD +DW + + +L+ MLT++ +KR +A Sbjct: 266 FDF------NDWKN-----------------------ISDEAKELIKLMLTYDYNKRCTA 296 Query: 287 FRALQHSYLHKDEGN 301 AL ++ K N Sbjct: 297 EEALNSRWIKKYANN 311 >3RAW-A nrPDB Length = 381 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 84/328 (25%), Positives = 143/328 (43%), Gaps = 47/328 (14%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHF-VALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 RYE V +G G +G V + D G VALK +R G + E+ +L+++ Sbjct: 52 RYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIR------NVGKYREAARLEINVLKKI 105 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 + + N + + V + + + + FE + ++ +L + P ++ + Q Sbjct: 106 KEKDKEN--KFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQ 163 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTS-------------------GGTVKLADFGLARI 164 L FLH N + H DLKPENIL + ++++ADFG A Sbjct: 164 LCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSA-T 222 Query: 165 YSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLG 224 + ++ T +V T YR PEV+L+ +A P D+WS+GCI E +R LF + + L Sbjct: 223 FDHEHH-TTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLV 281 Query: 225 KIFDLIGLPPEDDWPR--------------DVSLPRGAFPPRGPRPVQSVVPEMEESGAQ 270 + ++G P R D + G + +P++S + + Q Sbjct: 282 MMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQ 341 Query: 271 ---LLLEMLTFNPHKRISAFRALQHSYL 295 L+ ML F+P +RI+ AL H + Sbjct: 342 LFDLMRRMLEFDPAQRITLAEALLHPFF 369 >6QAU-A nrPDB Length = 280 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 70/221 (31%), Positives = 105/221 (47%), Gaps = 25/221 (11%) Query: 12 IGVGAYGTVYKARDPHSGHF-VALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +G GA+ V++ R + VA+KS+ N I +E+ +L+ L+ H N Sbjct: 19 VGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKS----QILLGKEIKILKELQ---HEN 71 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 +V L DV + V LV E+ + DL YL L +TI+ + Q + Sbjct: 72 IVALYDVQELPNS-----VFLVMEYCNGGDLADYLQAKGT--LSEDTIRVFLHQIAAAMR 124 Query: 130 FLHANCIVHRDLKPENILVT---------SGGTVKLADFGLARIYSYQMALTPVVVTLWY 180 LH+ I+HRDLKP+NIL++ SG +K+ADFG AR M + + Y Sbjct: 125 ILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPMY 184 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEAD 221 APEV++ Y D+WS+G + + KP F NS D Sbjct: 185 MAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD 225 >4LFI-A nrPDB Length = 374 Score = 99.0 bits (245), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 71/244 (29%), Positives = 121/244 (49%), Gaps = 26/244 (10%) Query: 68 HPNVVRLMDVCA--TSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQF 124 H N++ L D+ S+T LVFE+VD D R P L I+ M + Sbjct: 132 HANIIHLFDIIKDPISKTP-----ALVFEYVDNVDFRILY-----PKLTDLEIRFYMFEL 181 Query: 125 LRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183 L+ LD+ H+ I+HRD+KP N+++ ++L D+GLA Y M V + +++ P Sbjct: 182 LKALDYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGP 241 Query: 184 EVLLQ-STYATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGLPPEDDW--P 239 E+L+ Y +D+WS G + A M F+R+P F G S DQL KI ++G + + Sbjct: 242 ELLVDYRMYDYSLDLWSFGTMLASMIFKREPFFHGTSNTDQLVKIVKVLGTSDFEKYLLK 301 Query: 240 RDVSLPRGAFPPRG--PRPVQSVVPEMEE--SGA----QLLLEMLTFNPHKRISAFRALQ 291 +++LPR + +P + + + SG L+ +L ++ +R++A A+ Sbjct: 302 YEITLPREFYDMDQYIRKPWHRFINDGNKHLSGNDEIIDLIDNLLRYDHQERLTAKEAMG 361 Query: 292 HSYL 295 H + Sbjct: 362 HPWF 365 >2PVN-A nrPDB Length = 352 Score = 98.2 bits (243), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 57/167 (34%), Positives = 93/167 (55%), Gaps = 12/167 (7%) Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 PN+V+L+D+ R +L+FE+V+ D K P L I+ + + L+ Sbjct: 107 PNIVKLLDIV---RDQHSKTPSLIFEYVNNTDF-----KVLYPTLTDYDIRYYIYELLKA 158 Query: 128 LDFLHANCIVHRDLKPENILVTSG-GTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVL 186 LD+ H+ I+HRD+KP N+++ ++L D+GLA Y V + +++ PE+L Sbjct: 159 LDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELL 218 Query: 187 LQ-STYATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIG 231 + Y +DMWS+GC+FA M FR++P F G+ DQL KI ++G Sbjct: 219 VDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLG 265 >6EII-A nrPDB Length = 352 Score = 98.2 bits (243), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 75/248 (30%), Positives = 118/248 (47%), Gaps = 34/248 (13%) Query: 69 PNVVRLMDVCA--TSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFL 125 PN++ L D+ SRT LVFEHV+ D K L I+ M + L Sbjct: 115 PNIITLADIVKDPVSRT-----PALVFEHVNNTDF-----KQLYQTLTDYDIRFYMYEIL 164 Query: 126 RGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 + LD+ H+ I+HRD+KP N+++ ++L D+GLA Y V + +++ PE Sbjct: 165 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 224 Query: 185 VLLQ-STYATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGLPPEDDW---- 238 +L+ Y +DMWS+GC+ A M FR++P F G+ DQL +I ++G D+ Sbjct: 225 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 284 Query: 239 -----PRDVSLPRGAFPPRGPRPVQS-----VVPEMEESGAQLLLEMLTFNPHKRISAFR 288 PR + R R V S V PE L ++L ++ R++A Sbjct: 285 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPE----ALDFLDKLLRYDHQSRLTARE 340 Query: 289 ALQHSYLH 296 A++H Y + Sbjct: 341 AMEHPYFY 348 >6FD3-A nrPDB Length = 300 Score = 97.4 bits (241), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 66/209 (31%), Positives = 107/209 (51%), Gaps = 16/209 (7%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 +Y +IG GA GTVY A D +G VA+K + + + E+ ++R Sbjct: 23 KYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKE-----LIINEILVMRE-- 75 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 ++PN+V +D ++ +V E++ T D + I + R+ Sbjct: 76 -NKNPNIVNYLDSYLVGD-----ELWVVMEYLAGGSLT--DVVTETCMDEGQIAAVCREC 127 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGL-ARIYSYQMALTPVVVTLWYRAP 183 L+ LDFLH+N ++HRD+K +NIL+ G+VKL DFG A+I Q + +V T ++ AP Sbjct: 128 LQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAP 187 Query: 184 EVLLQSTYATPVDMWSVGCIFAEMFRRKP 212 EV+ + Y VD+WS+G + EM +P Sbjct: 188 EVVTRKAYGPKVDIWSLGIMAIEMVEGEP 216 >4MD7-E nrPDB Length = 391 Score = 97.4 bits (241), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 74/247 (29%), Positives = 118/247 (47%), Gaps = 32/247 (12%) Query: 69 PNVVRLMDVCA--TSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLR 126 PN++ L D+ SRT LVFEHV+ L + L I+ M + L+ Sbjct: 92 PNIITLADIVKDPVSRTP-----ALVFEHVNNTDFKQLYQT----LTDYDIRFYMYEILK 142 Query: 127 GLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 LD+ H+ I+HRD+KP N+++ ++L D+GLA Y V + +++ PE+ Sbjct: 143 ALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPEL 202 Query: 186 LLQ-STYATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGLPPEDDW----- 238 L+ Y +DMWS+GC+ A M FR++P F G+ DQL +I ++G D+ Sbjct: 203 LVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYN 262 Query: 239 ----PRDVSLPRGAFPPRGPRPVQS-----VVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 PR + R R V S V PE L ++L ++ R++A A Sbjct: 263 IELDPRFNDILGRHSRKRWERFVHSENQHLVSPE----ALDFLDKLLRYDHQSRLTAREA 318 Query: 290 LQHSYLH 296 ++H Y + Sbjct: 319 MEHPYFY 325 >5FG8-A nrPDB Length = 285 Score = 97.4 bits (241), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 90/304 (29%), Positives = 128/304 (42%), Gaps = 45/304 (14%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + Y+ E+G GA+ V + +G A K + RE + R+ Sbjct: 13 SDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQ---KLEREARICRK 69 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L HPN+VRL D E LVF+ V + D ++ Sbjct: 70 LH---HPNIVRLHD-----SIQEENYHYLVFDLVTGG-ELFEDIVAREFYSEADASHCIQ 120 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLA-RIYSYQMALTPVVVTL 178 Q L ++ H N +VHRDLKPEN+L+ S G VKLADFGLA + A T Sbjct: 121 QILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTP 180 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP---E 235 Y +PEVL + Y VD+W+ G I + L+G PP E Sbjct: 181 GYLSPEVLKKEPYGKSVDIWACGVILYIL---------------------LVGYPPFWDE 219 Query: 236 DDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 D + GA+ P +V PE + L+ +MLT NP+KRI+A AL+H ++ Sbjct: 220 DQHRLYSQIKAGAYDYPSPE-WDTVTPEAK----NLINQMLTVNPNKRITAAEALKHPWI 274 Query: 296 HKDE 299 + E Sbjct: 275 CQRE 278 >2XNP-A nrPDB Length = 279 Score = 97.1 bits (240), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 73/230 (31%), Positives = 108/230 (46%), Gaps = 18/230 (7%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 YE + IG G+YG K R G + K + + G V EV LLR L+ Sbjct: 8 YEVLYTIGTGSYGRCQKIRRKSDGKILVWKEL---DYGSMTEAEKQMLVSEVNLLRELK- 63 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPG--LPAETIKDLMR 122 HPN+VR D RT+ + + V E+ + DL + + K L E + +M Sbjct: 64 --HPNIVRYYDR-IIDRTNTTLYI--VMEYCEGGDLASVITKGTKERQYLDEEFVLRVMT 118 Query: 123 QFLRGLDFLH-----ANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV- 176 Q L H + ++HRDLKP N+ + VKL DFGLARI ++ + V Sbjct: 119 QLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVG 178 Query: 177 TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI 226 T +Y +PE + + +Y D+WS+GC+ E+ P F S+ + GKI Sbjct: 179 TPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKI 228 >6FYV-A nrPDB Length = 337 Score = 96.3 bits (238), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 88/331 (26%), Positives = 141/331 (42%), Gaps = 51/331 (15%) Query: 4 SRYEPVAEIGVGAYGTVYKARDP-HSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 +RYE V +G GA+G V + D G VA+K V+ G + E+ +L Sbjct: 14 ARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVK------NVGRYREAARSEIQVLEH 67 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L + + +V R + + D V +VFE + ++ + + I+ + Sbjct: 68 LNSTDPNSVFRCVQM--LEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAY 125 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTV-------------------KLADFGLAR 163 Q + ++FLH N + H DLKPENIL V K+ DFG A Sbjct: 126 QICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSA- 184 Query: 164 IYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQL 223 Y + T +V T YRAPEV+L ++ P D+WS+GCI E + +F + + L Sbjct: 185 TYDDEHHST-LVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHL 243 Query: 224 GKIFDLIGLPPED----------------DWPRDVSLPRGAFPPRGPRPVQSVV---PEM 264 + ++G P+ DW S G + R +P++ + E Sbjct: 244 AMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSA--GRYVRRRCKPLKEFMLCHDEE 301 Query: 265 EESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 E L+ ML ++P +RI+ ALQH + Sbjct: 302 HEKLFDLVRRMLEYDPTQRITLDEALQHPFF 332 >3BHH-A nrPDB Length = 295 Score = 96.3 bits (238), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 94/307 (30%), Positives = 127/307 (41%), Gaps = 59/307 (19%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 T Y+ +IG GA+ V + +GH A K + RE + R Sbjct: 3 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQ---KLEREARICRL 59 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-------DQDLRTYLDKAPPPGLPAE 115 L+ H N+VRL D E LVF+ V D R Y +A Sbjct: 60 LK---HSNIVRLHD-----SISEEGFHYLVFDLVTGGELFEDIVAREYYSEADAS----- 106 Query: 116 TIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLA-RIYSYQMAL 171 ++Q L + H +VHRDLKPEN+L+ S G VKLADFGLA + Q A Sbjct: 107 ---HCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAW 163 Query: 172 TPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG 231 T Y +PEVL + Y PVD+W+ G I + L+G Sbjct: 164 FGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYIL---------------------LVG 202 Query: 232 LPP---EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFR 288 PP ED + GA+ P +V PE L+ +MLT NP KRI+A Sbjct: 203 YPPFWDEDQHKLYQQIKAGAYDFPSPE-WDTVTPE----AKNLINQMLTINPAKRITAHE 257 Query: 289 ALQHSYL 295 AL+H ++ Sbjct: 258 ALKHPWV 264 >3KK8-A nrPDB Length = 284 Score = 96.3 bits (238), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 89/295 (30%), Positives = 126/295 (42%), Gaps = 44/295 (14%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + Y+ E+G GA+ V + +G A K + RE + R+ Sbjct: 5 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQ---KLEREARICRK 61 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L+ HPN+VRL D E LVF+ V + D ++ Sbjct: 62 LQ---HPNIVRLHD-----SIQEESFHYLVFDLVTGG-ELFEDIVAREFYSEADASHCIQ 112 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTLW 179 Q L + + H+N IVHR+LKPEN+L+ S G VKLADFGLA + A T Sbjct: 113 QILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPG 172 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP---ED 236 Y +PEVL + Y+ PVD+W+ G I + L+G PP ED Sbjct: 173 YLSPEVLKKDPYSKPVDIWACGVILYIL---------------------LVGYPPFWDED 211 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 + GA+ P +V PE + L+ MLT NP KRI+A +AL+ Sbjct: 212 QHRLYAQIKAGAYDYPSPE-WDTVTPEAK----SLIDSMLTVNPKKRITADQALK 261 >2BDW-A nrPDB Length = 362 Score = 95.9 bits (237), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 89/295 (30%), Positives = 126/295 (42%), Gaps = 44/295 (14%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + Y+ E+G GA+ V + +G A K + RE + R+ Sbjct: 28 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQ---KLEREARICRK 84 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L+ HPN+VRL D E LVF+ V + D ++ Sbjct: 85 LQ---HPNIVRLHD-----SIQEESFHYLVFDLVTGG-ELFEDIVAREFYSEADASHCIQ 135 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTLW 179 Q L + + H+N IVHR+LKPEN+L+ S G VKLADFGLA + A T Sbjct: 136 QILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPG 195 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP---ED 236 Y +PEVL + Y+ PVD+W+ G I + L+G PP ED Sbjct: 196 YLSPEVLKKDPYSKPVDIWACGVILYIL---------------------LVGYPPFWDED 234 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 + GA+ P +V PE + L+ MLT NP KRI+A +AL+ Sbjct: 235 QHRLYAQIKAGAYDYPSPE-WDTVTPEAK----SLIDSMLTVNPKKRITADQALK 284 >3Q53-A nrPDB Length = 306 Score = 95.5 bits (236), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 64/209 (30%), Positives = 107/209 (51%), Gaps = 16/209 (7%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 +Y +IG GA GTVY A D +G VA++ + + + E+ ++R Sbjct: 22 KYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKKE-----LIINEILVMRE-- 74 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 ++PN+V +D ++ +V E++ T D + I + R+ Sbjct: 75 -NKNPNIVNYLDSYLVGD-----ELWVVMEYLAGGSLT--DVVTETCMDEGQIAAVCREC 126 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGL-ARIYSYQMALTPVVVTLWYRAP 183 L+ L+FLH+N ++HRD+K +NIL+ G+VKL DFG A+I Q + +V T ++ AP Sbjct: 127 LQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAP 186 Query: 184 EVLLQSTYATPVDMWSVGCIFAEMFRRKP 212 EV+ + Y VD+WS+G + EM +P Sbjct: 187 EVVTRKAYGPKVDIWSLGIMAIEMIEGEP 215 >3MN3-A nrPDB Length = 271 Score = 95.1 bits (235), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 83/296 (28%), Positives = 131/296 (44%), Gaps = 44/296 (14%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSV--RVPNGGGGGGGLPISTVREVALLRRL 63 Y+ V +G G++G V A +G VALK + +V G + RE++ LR L Sbjct: 6 YQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDMQGRIE----REISYLRLL 61 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 HP++++L DV + ++ +V E+ +L Y+ + + + +Q Sbjct: 62 R---HPHIIKLYDVIKSKD-----EIIMVIEYAGNELFDYI--VQRDKMSEQEARRFFQQ 111 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183 + +++ H + IVHRDLKPEN+L+ VK+ADFGL+ I + L + Y AP Sbjct: 112 IISAVEYCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAP 171 Query: 184 EVLLQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 EV+ YA P VD+WS G I M R+ LP +D+ Sbjct: 172 EVISGKLYAGPEVDVWSCGVILYVMLCRR--------------------LPFDDE----- 206 Query: 243 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 S+P V ++ + A L+ ML NP RIS +Q + D Sbjct: 207 SIP--VLFKNISNGVYTLPKFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFKVD 260 >2V7O-A nrPDB Length = 336 Score = 95.1 bits (235), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 94/307 (30%), Positives = 128/307 (41%), Gaps = 59/307 (19%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 T Y+ E+G GA+ V + A K + RE + R Sbjct: 30 TDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQ---KLEREARICRL 86 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-------DQDLRTYLDKAPPPGLPAE 115 L+ HPN+VRL D E LVF+ V D R Y +A Sbjct: 87 LK---HPNIVRLHD-----SISEEGFHYLVFDLVTGGELFEDIVAREYYSEADAS----- 133 Query: 116 TIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLA-RIYSYQMAL 171 + Q L ++ +H + IVHRDLKPEN+L+ S G VKLADFGLA + Q A Sbjct: 134 ---HCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAW 190 Query: 172 TPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG 231 T Y +PEVL + Y PVD+W+ G I + L+G Sbjct: 191 FGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYIL---------------------LVG 229 Query: 232 LPP---EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFR 288 PP ED + GA+ P +V PE L+ +MLT NP KRI+A + Sbjct: 230 YPPFWDEDQHKLYQQIKAGAYDFPSPE-WDTVTPE----AKNLINQMLTINPAKRITADQ 284 Query: 289 ALQHSYL 295 AL+H ++ Sbjct: 285 ALKHPWV 291 >2VZ6-A nrPDB Length = 313 Score = 95.1 bits (235), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 93/306 (30%), Positives = 129/306 (42%), Gaps = 59/306 (19%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 S Y+ E+G GA+ V + +G A K + RE + R L Sbjct: 22 SMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQ---KLEREARICRLL 78 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-------DQDLRTYLDKAPPPGLPAET 116 + HPN+VRL D E L+F+ V D R Y +A Sbjct: 79 K---HPNIVRLHD-----SISEEGHHYLIFDLVTGGELFEDIVAREYYSEADAS------ 124 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLA-RIYSYQMALT 172 ++Q L + H +VHRDLKPEN+L+ S G VKLADFGLA + Q A Sbjct: 125 --HCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWF 182 Query: 173 PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGL 232 T Y +PEVL + Y PVD+W+ G I + L+G Sbjct: 183 GFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYIL---------------------LVGY 221 Query: 233 PP---EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 PP ED + GA+ P +V PE ++ L+ +MLT NP KRI+A A Sbjct: 222 PPFWDEDQHRLYQQIKAGAYDFPSPE-WDTVTPEAKD----LINKMLTINPSKRITAAEA 276 Query: 290 LQHSYL 295 L+H ++ Sbjct: 277 LKHPWI 282 >4WUA-A nrPDB Length = 401 Score = 94.7 bits (234), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 97/372 (26%), Positives = 152/372 (40%), Gaps = 85/372 (22%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + RY + ++G G + TV+ + D FVA+K V+ + + E+ LL Sbjct: 38 LFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK------SAEHYTETALDEIRLL 91 Query: 61 RRLEAFE--HPN---VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAE 115 + + + PN VV+L+D S + + +VFE + L ++ K+ GLP Sbjct: 92 KSVRNSDPNDPNREMVVQLLDDFKISGVNG-THICMVFEVLGHHLLKWIIKSNYQGLPLP 150 Query: 116 TIKDLMRQFLRGLDFLHANC-IVHRDLKPENILV-------------------------- 148 +K +++Q L+GLD+LH C I+H D+KPENIL+ Sbjct: 151 CVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPS 210 Query: 149 ---------TSGG--------------TVKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 T+G VK+AD G A T + T YR+ EV Sbjct: 211 GSAVSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNA--CWVHKHFTEDIQTRQYRSLEV 268 Query: 186 LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNS------EADQLGKIFDLIGLPPED--- 236 L+ S Y TP D+WS C+ E+ LF +S + D + I +L+G P Sbjct: 269 LIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIV 328 Query: 237 --DWPRDVSLPRG------AFPPRGPRPVQSVVPEMEESGA----QLLLEMLTFNPHKRI 284 + ++ +G P G V E + A LL ML P KR Sbjct: 329 AGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRA 388 Query: 285 SAFRALQHSYLH 296 +A L+H +L+ Sbjct: 389 TAAECLRHPWLN 400 >2XIK-A nrPDB Length = 294 Score = 94.7 bits (234), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 106/208 (50%), Gaps = 15/208 (7%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 + + IG G++G VYK D H+ VA+K + + +E+ +L + ++ Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAED----EIEDIQQEITVLSQCDS 76 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 P + R S K+ ++ E++ + LD P L I ++R+ L Sbjct: 77 ---PYITRYFGSYLKS-----TKLWIIMEYLGGG--SALDLLKPGPLEETYIATILREIL 126 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLA-RIYSYQMALTPVVVTLWYRAPE 184 +GLD+LH+ +HRD+K N+L++ G VKLADFG+A ++ Q+ V T ++ APE Sbjct: 127 KGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE 186 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKP 212 V+ QS Y D+WS+G E+ + +P Sbjct: 187 VIKQSAYDFKADIWSLGITAIELAKGEP 214 >5YKS-A nrPDB Length = 377 Score = 94.4 bits (233), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 72/226 (31%), Positives = 107/226 (47%), Gaps = 15/226 (6%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y+ +G G + V AR +G VA+K + G VR + L+ Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVRCMKLV----- 91 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQF 124 +HPN+VRL +V D + K+ L+ E D D+ Y+ K GL + K Q Sbjct: 92 -QHPNIVRLYEV-----IDTQTKLYLILELGDGGDMFDYIMKHEE-GLNEDLAKKYFAQI 144 Query: 125 LRGLDFLHANCIVHRDLKPENIL-VTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183 + + + H +VHRDLKPEN++ G VKL DFG + + LT +L Y AP Sbjct: 145 VHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAP 204 Query: 184 EVLLQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD 228 E+LL Y P VD+WS+G I + +P F ++++ L I D Sbjct: 205 EILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMD 250 >2WQN-A nrPDB Length = 310 Score = 94.4 bits (233), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 66/212 (31%), Positives = 107/212 (50%), Gaps = 14/212 (6%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +IG G + VY+A G VALK V++ + ++E+ LL++L HPN Sbjct: 39 KIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKAR--ADCIKEIDLLKQLN---HPN 93 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLD--KAPPPGLPAETIKDLMRQFLRG 127 V++ A+ D E+ + V E D DL + K +P T+ Q Sbjct: 94 VIKYY---ASFIEDNELNI--VLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSA 148 Query: 128 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ-MALTPVVVTLWYRAPEVL 186 L+ +H+ ++HRD+KP N+ +T+ G VKL D GL R +S + A +V T +Y +PE + Sbjct: 149 LEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERI 208 Query: 187 LQSTYATPVDMWSVGCIFAEMFRRKPLFCGNS 218 ++ Y D+WS+GC+ EM + F G+ Sbjct: 209 HENGYNFKSDIWSLGCLLYEMAALQSPFYGDK 240 >5U6Y-A nrPDB Length = 461 Score = 94.0 bits (232), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 92/304 (30%), Positives = 129/304 (42%), Gaps = 59/304 (19%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y+ E+G GA+ V + +G A K + RE + R L+ Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQ---KLEREARICRLLK- 57 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHV-------DQDLRTYLDKAPPPGLPAETIK 118 HPN+VRL D + E L+F+ V D R Y +A Sbjct: 58 --HPNIVRLHDSIS-----EEGHHYLIFDLVTGGELFEDIVAREYYSEADAS-------- 102 Query: 119 DLMRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLA-RIYSYQMALTPV 174 ++Q L + H +VHRDLKPEN+L+ S G VKLADFGLA + Q A Sbjct: 103 HCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGF 162 Query: 175 VVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 T Y +PEVL + Y PVD+W+ G I + L+G PP Sbjct: 163 AGTPGYLSPEVLRKDPYGKPVDLWACGVILYIL---------------------LVGYPP 201 Query: 235 ---EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 ED + GA+ P +V PE ++ L+ +MLT NP KRI+A AL+ Sbjct: 202 FWDEDQHRLYQQIKAGAYDFPSPE-WDTVTPEAKD----LINKMLTINPSKRITAAEALK 256 Query: 292 HSYL 295 H ++ Sbjct: 257 HPWI 260 >4QMW-A nrPDB Length = 310 Score = 93.2 bits (230), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 60/208 (28%), Positives = 108/208 (51%), Gaps = 15/208 (7%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 + + +IG G++G V+K D + VA+K + + +E+ +L + ++ Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAED----EIEDIQQEITVLSQCDS 86 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 P V + ++ K+ ++ E++ + LD P L I ++R+ L Sbjct: 87 ---PYVTKYYGSYL-----KDTKLWIIMEYLGGG--SALDLLEPGPLDETQIATILREIL 136 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLA-RIYSYQMALTPVVVTLWYRAPE 184 +GLD+LH+ +HRD+K N+L++ G VKLADFG+A ++ Q+ V T ++ APE Sbjct: 137 KGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE 196 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKP 212 V+ QS Y + D+WS+G E+ R +P Sbjct: 197 VIKQSAYDSKADIWSLGITAIELARGEP 224 >5X8I-B nrPDB Length = 346 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 87/341 (25%), Positives = 144/341 (42%), Gaps = 69/341 (20%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSG-HFVALKSVRVPNGGGGGGGLPISTVREVA--- 58 ++RYE V +G GA+G V + D +G VA+K V+ + I + + Sbjct: 12 SARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTD 71 Query: 59 ------LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGL 112 ++ LE FEH + +VFE + ++ + Sbjct: 72 PNSTFRCVQMLEWFEHHG-----------------HICIVFELLGLSTYDFIKENGFLPF 114 Query: 113 PAETIKDLMRQFLRGLDFLHANCIVHRDLKPENIL-VTSGGT------------------ 153 + I+ + Q + ++FLH+N + H DLKPENIL V S T Sbjct: 115 RLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPD 174 Query: 154 VKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPL 213 +K+ DFG A Y + T +V T YRAPEV+L ++ P D+WS+GCI E + + Sbjct: 175 IKVVDFGSA-TYDDEHHST-LVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTV 232 Query: 214 FCGNSEADQLGKIFDLIGLPPED----------------DWPRDVSLPRGAFPPRGPRPV 257 F + + L + ++G P+ DW S G + R +P+ Sbjct: 233 FPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSA--GRYVSRACKPL 290 Query: 258 QSVVPEME---ESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 + + + E L+ +ML ++P KRI+ AL+H + Sbjct: 291 KEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF 331 >4RED-A nrPDB Length = 351 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 88/296 (29%), Positives = 132/296 (44%), Gaps = 55/296 (18%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR----LEAFE 67 +GVG +G V + +GH VA+K + I ++ V +RR L+ F Sbjct: 22 LGVGTFGKVKVGKHELTGHAVAVKILNRQK---------IRSLDVVGKIRREIQNLKLFR 72 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLR 126 HP++++L V +T + +V E+V +L Y+ K L + + L +Q L Sbjct: 73 HPHIIKLYQVISTPS-----DIFMVMEYVSGGELFDYICKNGR--LDEKESRRLFQQILS 125 Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVL 186 G+D+ H + +VHRDLKPEN+L+ + K+ADFGL+ + S L + Y APEV+ Sbjct: 126 GVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 185 Query: 187 LQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV--S 243 YA P VD+WS G I L CG LP +DD + Sbjct: 186 SGRLYAGPEVDIWSSGVILY------ALLCGT--------------LPFDDDHVPTLFKK 225 Query: 244 LPRGAF-PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + G F P+ P S LL ML +P KR S +H + +D Sbjct: 226 ICDGIFYTPQYLNP----------SVISLLKHMLQVDPMKRASIKDIREHEWFKQD 271 >4REW-A nrPDB Length = 540 Score = 92.0 bits (227), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 87/299 (29%), Positives = 129/299 (43%), Gaps = 61/299 (20%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR----LEAFE 67 +GVG +G V + +GH VA+K + I ++ V +RR L+ F Sbjct: 14 LGVGTFGKVKVGKHELTGHKVAVKILNRQK---------IRSLDVVGKIRREIQNLKLFR 64 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLR 126 HP++++L V +T + +V E+V +L Y+ K L + + L +Q L Sbjct: 65 HPHIIKLYQVISTPS-----DIFMVMEYVSGGELFDYICKNG--RLDEKESRRLFQQILS 117 Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVL 186 G+D+ H + +VHRDLKPEN+L+ + K+ADFGL+ + S L + Y APEV+ Sbjct: 118 GVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 177 Query: 187 LQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQ------LGKIFDLIGLPPEDDWP 239 YA P VD+WS G I L CG D KI D I P+ P Sbjct: 178 SGRLYAGPEVDIWSSGVILY------ALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNP 231 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 +S LL ML +P KR S +H + +D Sbjct: 232 SVIS---------------------------LLKHMLQVDPMKRASIKDIREHEWFKQD 263 >2GCD-A nrPDB Length = 309 Score = 91.7 bits (226), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 72/217 (33%), Positives = 107/217 (49%), Gaps = 18/217 (8%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 + + EIG G++G VY ARD + VA+K ++ G ++EV L++L Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIK--KMSYSGKQSNEKWQDIIKEVRFLQKLR- 73 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 HPN ++ C RE LV E+ L+ P L I + L Sbjct: 74 --HPNTIQYRG-CYL----REHTAWLVMEYCLGSASDLLEVHKKP-LQEVEIAAVTHGAL 125 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 +GL +LH++ ++HRD+K NIL++ G VKL DFG A I + V T ++ APEV Sbjct: 126 QGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMA---PANSFVGTPYWMAPEV 182 Query: 186 LL---QSTYATPVDMWSVGCIFAEMFRRK-PLFCGNS 218 +L + Y VD+WS+G E+ RK PLF N+ Sbjct: 183 ILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNA 219 >3SOA-A nrPDB Length = 444 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 92/307 (29%), Positives = 130/307 (42%), Gaps = 59/307 (19%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 T Y+ E+G GA+ V + +G A + N RE + R Sbjct: 10 TEEYQLFEELGKGAFSVVRRCVKVLAGQEYA---AMIINTKKLSARDHQKLEREARICRL 66 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-------DQDLRTYLDKAPPPGLPAE 115 L+ HPN+VRL D + E L+F+ V D R Y +A Sbjct: 67 LK---HPNIVRLHDSIS-----EEGHHYLIFDLVTGGELFEDIVAREYYSEADAS----- 113 Query: 116 TIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLA-RIYSYQMAL 171 ++Q L + H +VHR+LKPEN+L+ S G VKLADFGLA + Q A Sbjct: 114 ---HCIQQILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAW 170 Query: 172 TPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG 231 T Y +PEVL + Y PVD+W+ G I + L+G Sbjct: 171 FGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYIL---------------------LVG 209 Query: 232 LPP---EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFR 288 PP ED + GA+ P +V PE ++ L+ +MLT NP KRI+A Sbjct: 210 YPPFWDEDQHRLYQQIKAGAYDFPSPE-WDTVTPEAKD----LINKMLTINPSKRITAAE 264 Query: 289 ALQHSYL 295 AL+H ++ Sbjct: 265 ALKHPWI 271 >1U5R-A nrPDB Length = 348 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 71/217 (32%), Positives = 106/217 (48%), Gaps = 18/217 (8%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 + + EIG G++G VY ARD + VA+K ++ G ++EV L++L Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIK--KMSYSGKQSNEKWQDIIKEVRFLQKLR- 112 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 HPN ++ RE LV E+ L+ P L I + L Sbjct: 113 --HPNTIQYRGCYL-----REHTAWLVMEYCLGSASDLLEVHKKP-LQEVEIAAVTHGAL 164 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 +GL +LH++ ++HRD+K NIL++ G VKL DFG A I + V T ++ APEV Sbjct: 165 QGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMA---PANSFVGTPYWMAPEV 221 Query: 186 LL---QSTYATPVDMWSVGCIFAEMFRRK-PLFCGNS 218 +L + Y VD+WS+G E+ RK PLF N+ Sbjct: 222 ILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNA 258 >4CFH-A nrPDB Length = 493 Score = 91.3 bits (225), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 78/245 (31%), Positives = 116/245 (47%), Gaps = 34/245 (13%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR----LEAFE 67 +GVG +G V + +GH VA+K + I ++ V +RR L+ F Sbjct: 41 LGVGTFGKVKVGKHELTGHKVAVKILNRQK---------IRSLDVVGKIRREIQNLKLFR 91 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLR 126 HP++++L V +T + +V E+V +L Y+ K L + + L +Q L Sbjct: 92 HPHIIKLYQVISTPSD-----IFMVMEYVSGGELFDYICKNG--RLDEKESRRLFQQILS 144 Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVL 186 G+D+ H + +VHRDLKPEN+L+ + K+ADFGL+ + S L + Y APEV+ Sbjct: 145 GVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVI 204 Query: 187 LQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQ------LGKIFDLIGLPPEDDWP 239 YA P VD+WS G I L CG D KI D I P+ P Sbjct: 205 SGRLYAGPEVDIWSSGVILY------ALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNP 258 Query: 240 RDVSL 244 +SL Sbjct: 259 SVISL 263 >2YAB-A nrPDB Length = 361 Score = 91.3 bits (225), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 69/227 (30%), Positives = 107/227 (47%), Gaps = 16/227 (7%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTV-REVALLRRLE 64 Y+ E+G G + V K R+ +G A K ++ G+ + REV++LR++ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQVL 73 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQ 123 HPN++ L DV +RTD V L+ E V +L +L A L E ++Q Sbjct: 74 ---HPNIITLHDVYE-NRTD----VVLILELVSGGELFDFL--AQKESLSEEEATSFIKQ 123 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGT----VKLADFGLARIYSYQMALTPVVVTLW 179 L G+++LH I H DLKPENI++ +KL DFGLA + + T Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI 226 + APE++ DMWS+G I + F G+++ + L I Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANI 230 >4MVF-A nrPDB Length = 506 Score = 90.9 bits (224), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 77/297 (25%), Positives = 127/297 (42%), Gaps = 47/297 (15%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSV---RVPNGGGGGGGLPISTVREVALLR 61 +Y ++G G YG VYK D + A+K R+ N +E+ +++ Sbjct: 58 KYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNIN--------RFFQEIEIMK 109 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 +L+ HPN+V+L + T D I + + + + ++ A TI M Sbjct: 110 KLD---HPNIVKLYE---TYENDNYIYLIMELCSGRELFDSIIENGSFTEKNAATI---M 160 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGT---VKLADFGLARIYSYQMALTPVVVTL 178 +Q + +LH+ IVHRDLKPEN L S +K+ DFGL++ T T Sbjct: 161 KQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTP 220 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 +Y AP+V L Y D+WS G I + P F G+++ + L K+ E+DW Sbjct: 221 YYVAPQV-LDGKYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDW 279 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 + L+ ++LT+NP++R + AL H ++ Sbjct: 280 GS-----------------------ISSDAKNLITKLLTYNPNERCTIEEALNHPWI 313 >2Y7J-A nrPDB Length = 365 Score = 90.5 bits (223), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 84/306 (27%), Positives = 133/306 (43%), Gaps = 48/306 (15%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPI---STVREVALLR 61 +Y+P IG G V + +GH A+K + V L +T RE +LR Sbjct: 95 KYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILR 154 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDL 120 ++ HP+++ L+D +S + LVF+ + + +L YL + L + + + Sbjct: 155 QVAG--HPHIITLIDSYESSSF-----MFLVFDLMRKGELFDYLTEKV--ALSEKETRSI 205 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY 180 MR L + FLHAN IVHRDLKPENIL+ ++L+DFG + L + T Y Sbjct: 206 MRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPGY 265 Query: 181 RAPEVLLQST------YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 APE+L S Y VD+W+ G I + P F + L I + Sbjct: 266 LAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIME------ 319 Query: 235 EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGA---QLLLEMLTFNPHKRISAFRALQ 291 G + Q PE ++ + L+ +L +P R++A +ALQ Sbjct: 320 ------------GQY--------QFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQALQ 359 Query: 292 HSYLHK 297 H + + Sbjct: 360 HPFFER 365 >5UNP-A nrPDB Length = 369 Score = 90.5 bits (223), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 86/338 (25%), Positives = 139/338 (41%), Gaps = 51/338 (15%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPH-SGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 RYE V+ +G G +G V + D G VALK ++ L I+ + ++ Sbjct: 34 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINE--- 90 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 + P+ L V D + + FE + +L P ++ + Sbjct: 91 ----KDPDNKNLC-VQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAF 145 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGG-------------------TVKLADFGLAR 163 Q + + FLH N + H DLKPENIL + V++ DFG A Sbjct: 146 QLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSA- 204 Query: 164 IYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQL 223 + ++ T +V T YRAPEV+L+ ++ P D+WS+GCI E + LF + + L Sbjct: 205 TFDHEHHST-IVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHL 263 Query: 224 GKIFDLIGLPPED----------------DWPRDVSLPRGAFPPRGPRPVQSVVPEMEES 267 + ++G P DW + S G + +P++ + E Sbjct: 264 AMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSA--GRYVRENCKPLRRYLTSEAEE 321 Query: 268 GAQL--LLE-MLTFNPHKRISAFRALQHSYLHKDEGNP 302 QL L+E ML + P KR++ ALQH + + P Sbjct: 322 HHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEP 359 >6HMD-A nrPDB Length = 365 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 54/167 (32%), Positives = 89/167 (53%), Gaps = 14/167 (8%) Query: 70 NVVRLMDVCA--TSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 N+++L+D S+T LVFE+++ L + L I+ M + L+ Sbjct: 109 NIIKLIDTVKDPVSKTP-----ALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLKA 159 Query: 128 LDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVL 186 LD+ H+ I+HRD+KP N+++ ++L D+GLA Y V + +++ PE+L Sbjct: 160 LDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELL 219 Query: 187 LQ-STYATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIG 231 + Y +DMWS+GC+ A M FRR+P F G DQL +I ++G Sbjct: 220 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG 266 >5XZW-A nrPDB Length = 471 Score = 89.7 bits (221), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 81/300 (27%), Positives = 137/300 (45%), Gaps = 53/300 (17%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G GA+ TV KA + +G A+K + G G+ RE+ +L++L HP + Sbjct: 204 VGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGV----TRELEVLQKLN---HPRI 256 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 VRL + + +V E V DL ++ A + + +++ RQ L + + Sbjct: 257 VRLKGFYEDTES-----YYMVMEFVSGGDLMDFV--AAHGAVGEDAGREISRQILTAIKY 309 Query: 131 LHANCIVHRDLKPENILVTSGG--TVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLL- 187 +H+ I HRDLKP+NIL+ VK+ DFGLA++ + TL Y APEV+ Sbjct: 310 IHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRG 369 Query: 188 ------------QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPE 235 ++ Y++ VDMWS+GC+ + F G+++ DQL K Sbjct: 370 KDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ-DQLYK---------- 418 Query: 236 DDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 + RG++ GP + E + + +L +P+ R +A +AL H ++ Sbjct: 419 -------QIGRGSY-HEGPLKDFRISEEARD----FIDSLLQVDPNNRSTAAKALNHPWI 466 >4KS7-A nrPDB Length = 292 Score = 89.7 bits (221), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 84/295 (28%), Positives = 131/295 (44%), Gaps = 41/295 (13%) Query: 10 AEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHP 69 +IG G+ G V AR+ HSG VA+K + + EV ++R ++H Sbjct: 29 VKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRE-----LLFNEVVIMR---DYQHF 80 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 NVV + + E+ V + F D L E I + L+ L Sbjct: 81 NVVEMY---KSYLVGEELWVLMEFLQGG----ALTDIVSQVRLNEEQIATVCEAVLQALA 133 Query: 130 FLHANCIVHRDLKPENILVTSGGTVKLADFGL-ARIYSYQMALTPVVVTLWYRAPEVLLQ 188 +LHA ++HRD+K ++IL+T G VKL+DFG A+I +V T ++ APEV+ + Sbjct: 134 YLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISR 193 Query: 189 STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGA 248 S YAT VD+WS+G + EM +P + +S + ++ D Sbjct: 194 SLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRD-------------------- 233 Query: 249 FPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 303 PP + V P + + L ML +P +R +A L H +L + G PE Sbjct: 234 SPPPKLKNSHKVSPVLRD----FLERMLVRDPQERATAQELLDHPFLLQ-TGLPE 283 >3GUB-A nrPDB Length = 295 Score = 89.7 bits (221), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 77/296 (26%), Positives = 131/296 (44%), Gaps = 39/296 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTV-REVALLRRLE 64 Y+ E+G G + V K R+ +G A K ++ G+ + REV++L+ ++ Sbjct: 13 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQ 72 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQ 123 HPNV+ L +V ++TD V L+ E V +L +L A L E + ++Q Sbjct: 73 ---HPNVITLHEVYE-NKTD----VILIGELVAGGELFDFL--AEKESLTEEEATEFLKQ 122 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGT----VKLADFGLARIYSYQMALTPVVVTLW 179 L G+ +LH+ I H DLKPENI++ +K+ DFGLA + + T Sbjct: 123 ILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPE 182 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 + APE++ DMWS+G I + F G+++ + L + + ED++ Sbjct: 183 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANV-SAVNYEFEDEYF 241 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 + S F R +L +P KR++ +LQH ++ Sbjct: 242 SNTSALAKDFIRR----------------------LLVKDPKKRMTIQDSLQHPWI 275 >4YZB-A nrPDB Length = 491 Score = 89.7 bits (221), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 58/179 (32%), Positives = 87/179 (48%), Gaps = 27/179 (15%) Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVV 176 ++RQ L G+ ++H N IVHRDLKPEN+L+ + +++ DFGL+ + + + Sbjct: 135 IIRQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIG 194 Query: 177 TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPED 236 T +Y APEVL TY D+WS G I + P F G +E D L K+ Sbjct: 195 TAYYIAPEVL-HGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKV---------- 243 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 +G F P+ ++ E L+ +ML + P RISA AL+H +L Sbjct: 244 --------EKGKFTFDLPQW-----KKVSEPAKDLIRKMLAYVPTMRISARDALEHEWL 289 >2YZA-A nrPDB Length = 276 Score = 89.7 bits (221), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 87/295 (29%), Positives = 132/295 (44%), Gaps = 53/295 (17%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR----LEAFE 67 +GVG +G V +GH VA+K + I ++ V ++R L+ F Sbjct: 19 LGVGTFGKVKIGEHQLTGHKVAVKILNRQK---------IRSLDVVGKIKREIQNLKLFR 69 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLR 126 HP++++L V +T TD +V E+V +L Y+ K + + L +Q L Sbjct: 70 HPHIIKLYQVISTP-TD----FFMVMEYVSGGELFDYICKHGR--VEEMEARRLFQQILS 122 Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVL 186 +D+ H + +VHRDLKPEN+L+ + K+ADFGL+ + S L + Y APEV+ Sbjct: 123 AVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVI 182 Query: 187 LQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW-PRDVSL 244 YA P VD+WS G I L CG LP +D+ P Sbjct: 183 SGRLYAGPEVDIWSCGVILY------ALLCGT--------------LPFDDEHVPTLFKK 222 Query: 245 PRGAFPPRGPRPVQSVVPE-MEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 RG +PE + S A LL+ ML +P KR + +H + +D Sbjct: 223 IRGGV---------FYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQD 268 >4CFF-A nrPDB Length = 571 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 89/296 (30%), Positives = 133/296 (44%), Gaps = 55/296 (18%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR----LEAFE 67 +GVG +G V +GH VA+K + I ++ V ++R L+ F Sbjct: 41 LGVGTFGKVKIGEHQLTGHKVAVKILNRQK---------IRSLDVVGKIKREIQNLKLFR 91 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAET-IKDLMRQFL 125 HP++++L V +T TD +V E+V +L Y+ K G E + L +Q L Sbjct: 92 HPHIIKLYQVISTP-TD----FFMVMEYVSGGELFDYICKH---GRVEEMEARRLFQQIL 143 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 +D+ H + +VHRDLKPEN+L+ + K+ADFGL+ + S L + Y APEV Sbjct: 144 SAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV 203 Query: 186 LLQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW-PRDVS 243 + YA P VD+WS G I L CG LP +D+ P Sbjct: 204 ISGRLYAGPEVDIWSCGVILY------ALLCGT--------------LPFDDEHVPTLFK 243 Query: 244 LPRGAFPPRGPRPVQSVVPE-MEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 RG +PE + S A LL+ ML +P KR + +H + +D Sbjct: 244 KIRGGV---------FYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQD 290 >1ZWS-A nrPDB Length = 288 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 69/227 (30%), Positives = 106/227 (46%), Gaps = 16/227 (7%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTV-REVALLRRLE 64 Y+ E+G G + V K R+ +G A K ++ G+ + REV++LR++ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQ 123 H NV+ L DV +RTD V L+ E V +L +L A L E ++Q Sbjct: 74 ---HHNVITLHDVYE-NRTD----VVLILELVSGGELFDFL--AQKESLSEEEATSFIKQ 123 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGT----VKLADFGLARIYSYQMALTPVVVTLW 179 L G+++LH I H DLKPENI++ +KL DFGLA + + T Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI 226 + APE++ DMWS+G I + F G+++ + L I Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANI 230 >5EZV-A nrPDB Length = 560 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 89/296 (30%), Positives = 133/296 (44%), Gaps = 55/296 (18%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR----LEAFE 67 +GVG +G V +GH VA+K + I ++ V ++R L+ F Sbjct: 36 LGVGTFGKVKIGEHQLTGHKVAVKILNRQK---------IRSLDVVGKIKREIQNLKLFR 86 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAET-IKDLMRQFL 125 HP++++L V +T TD +V E+V +L Y+ K G E + L +Q L Sbjct: 87 HPHIIKLYQVISTP-TD----FFMVMEYVSGGELFDYICKH---GRVEEMEARRLFQQIL 138 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 +D+ H + +VHRDLKPEN+L+ + K+ADFGL+ + S L + Y APEV Sbjct: 139 SAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV 198 Query: 186 LLQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW-PRDVS 243 + YA P VD+WS G I L CG LP +D+ P Sbjct: 199 ISGRLYAGPEVDIWSCGVILY------ALLCGT--------------LPFDDEHVPTLFK 238 Query: 244 LPRGAFPPRGPRPVQSVVPE-MEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 RG +PE + S A LL+ ML +P KR + +H + +D Sbjct: 239 KIRGGV---------FYIPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQD 285 >3COM-A nrPDB Length = 314 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 75/297 (25%), Positives = 136/297 (45%), Gaps = 42/297 (14%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 ++ + ++G G+YG+VYKA +G VA+K V V + ++E++++++ ++ Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQ-------EIIKEISIMQQCDS 83 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 P+VV+ TD + +V E+ + + + L + I +++ L Sbjct: 84 ---PHVVKYYG-SYFKNTD----LWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTL 135 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLWYRAPE 184 +GL++LH +HRD+K NIL+ + G KLADFG+A + MA V+ T ++ APE Sbjct: 136 KGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 195 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244 V+ + Y D+WS+G EM KP + D+ Sbjct: 196 VIQEIGYNCVADIWSLGITAIEMAEGKPPYA-------------------------DIHP 230 Query: 245 PRGAFP-PRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 300 R F P P P ++ + + L +P +R +A + LQH ++ +G Sbjct: 231 MRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKG 287 >2A27-A nrPDB Length = 321 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 69/227 (30%), Positives = 106/227 (46%), Gaps = 16/227 (7%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTV-REVALLRRLE 64 Y+ E+G G + V K R+ +G A K ++ G+ + REV++LR++ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQVL 73 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQ 123 H NV+ L DV +RTD V L+ E V +L +L A L E ++Q Sbjct: 74 ---HHNVITLHDVYE-NRTD----VVLILELVSGGELFDFL--AQKESLSEEEATSFIKQ 123 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGT----VKLADFGLARIYSYQMALTPVVVTLW 179 L G+++LH I H DLKPENI++ +KL DFGLA + + T Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI 226 + APE++ DMWS+G I + F G+++ + L I Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANI 230 >4WNO-A nrPDB Length = 287 Score = 89.0 bits (219), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 68/221 (30%), Positives = 103/221 (46%), Gaps = 25/221 (11%) Query: 12 IGVGAYGTVYKARDPHSGHF-VALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 IG GA+ V+K R + VA+K + N L +E+ +L+ L+ H N Sbjct: 26 IGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLG----KEIKILKELK---HEN 78 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 +V L D + + V LV E+ + DL YL L +TI+ ++Q + Sbjct: 79 IVALYDFQEMANS-----VYLVMEYCNGGDLADYLHAMRT--LSEDTIRLFLQQIAGAMR 131 Query: 130 FLHANCIVHRDLKPENILVTSGG---------TVKLADFGLARIYSYQMALTPVVVTLWY 180 LH+ I+HRDLKP+NIL+++ VK+ADFG AR M + + Y Sbjct: 132 LLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMY 191 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEAD 221 APEV++ Y D+WS+G I + K F +S D Sbjct: 192 MAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD 232 >2J90-A nrPDB Length = 304 Score = 89.0 bits (219), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 75/301 (24%), Positives = 128/301 (42%), Gaps = 39/301 (12%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTV-REVAL 59 M YE E+G G + V K R +G A K ++ G+ + REV + Sbjct: 23 MVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNI 82 Query: 60 LRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIK 118 LR + HPN++ L D+ ++TD V L+ E V +L +L A L + Sbjct: 83 LREIR---HPNIITLHDIFE-NKTD----VVLILELVSGGELFDFL--AEKESLTEDEAT 132 Query: 119 DLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGT----VKLADFGLARIYSYQMALTPV 174 ++Q L G+ +LH+ I H DLKPENI++ +KL DFG+A + Sbjct: 133 QFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNI 192 Query: 175 VVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 T + APE++ DMWS+G I + F G ++ + L I + Sbjct: 193 FGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNI-SAVNYDF 251 Query: 235 EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294 ++++ + S E + +L +P +R++ ++L+HS+ Sbjct: 252 DEEYFSNTS----------------------ELAKDFIRRLLVKDPKRRMTIAQSLEHSW 289 Query: 295 L 295 + Sbjct: 290 I 290 >6CMJ-A nrPDB Length = 321 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 66/222 (29%), Positives = 114/222 (51%), Gaps = 19/222 (8%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGL-----PISTV-REV 57 +Y EIG G+YG V A + + + A+K + GG PI V +E+ Sbjct: 34 DQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEI 93 Query: 58 ALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETI 117 A+L++L+ HPNVV+L++V D + +VFE V+Q + P L + Sbjct: 94 AILKKLD---HPNVVKLVEVLDDPNEDH---LYMVFELVNQGPVMEVPTLKP--LSEDQA 145 Query: 118 KDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-LTPVVV 176 + + ++G+++LH I+HRD+KP N+LV G +K+ADFG++ + A L+ V Sbjct: 146 RFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVG 205 Query: 177 TLWYRAPEVLLQST---YATPVDMWSVGC-IFAEMFRRKPLF 214 T + APE L ++ +D+W++G ++ +F + P Sbjct: 206 TPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFM 247 >4FG9-A nrPDB Length = 320 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 78/291 (26%), Positives = 127/291 (43%), Gaps = 41/291 (14%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G GA+ V A D + VA+K + G G + E+A+L +++ HPN+ Sbjct: 26 LGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSME----NEIAVLHKIK---HPNI 78 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAE-TIKDLMRQFLRGLDF 130 V L D+ + + L+ + V D+ G E L+ Q L + + Sbjct: 79 VALDDIYESGG-----HLYLIMQLVSGG--ELFDRIVEKGFYTERDASRLIFQVLDAVKY 131 Query: 131 LHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLL 187 LH IVHRDLKPEN+L S + ++DFGL+++ L+ T Y APEVL Sbjct: 132 LHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLA 191 Query: 188 QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRG 247 Q Y+ VD WS+G I + P F ++A K+F+ I + Sbjct: 192 QKPYSKAVDCWSIGVIAYILLCGYPPFYDENDA----KLFEQI--------------LKA 233 Query: 248 AFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + P ++ +S + ++ +P KR + +ALQH ++ D Sbjct: 234 EYEFDSP-----YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGD 279 >2WTK-C nrPDB Length = 305 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 83/303 (27%), Positives = 130/303 (42%), Gaps = 63/303 (20%) Query: 12 IGVGAYGTVYKARDPHS------GHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +G G+YG V + D + K R+PNG + +E+ LLRRL Sbjct: 13 LGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEA-------NVKKEIQLLRRLR- 64 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 H NV++L+DV + + K+ +V E+ ++ LD P P Q + Sbjct: 65 --HKNVIQLVDVL---YNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLI 119 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV--------- 176 GL++LH+ IVH+D+KP N+L+T+GGT+K++ G+A AL P Sbjct: 120 DGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAE------ALHPFAADDTCRTSQG 173 Query: 177 TLWYRAPEVL--LQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 + ++ PE+ L + VD+WS G + F E D + K+F+ IG Sbjct: 174 SPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPF----EGDNIYKLFENIG--- 226 Query: 235 EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294 ++P PP + LL ML + P KR S + QHS+ Sbjct: 227 ----KGSYAIPGDCGPPL----------------SDLLKGMLEYEPAKRFSIRQIRQHSW 266 Query: 295 LHK 297 K Sbjct: 267 FRK 269 >4E93-A nrPDB Length = 377 Score = 87.4 bits (215), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 62/206 (30%), Positives = 99/206 (48%), Gaps = 25/206 (12%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVR--VPNGGGGGGGLPISTVREVALLRRLEAFEH 68 +IG G +G V+ R VA+KS R +P P + + R L+ + H Sbjct: 121 QIGRGNFGEVFSGRLRADNTLVAVKSCRETLP---------PDLKAKFLQEARILKQYSH 171 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 PN+VRL+ VC + + +V E V D T+L + L +T+ ++ G Sbjct: 172 PNIVRLIGVCTQKQP-----IYIVMELVQGGDFLTFL-RTEGARLRVKTLLQMVGDAAAG 225 Query: 128 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-----IYSYQMALTPVVVTLWYRA 182 +++L + C +HRDL N LVT +K++DFG++R +Y+ L V V + A Sbjct: 226 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVK--WTA 283 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMF 208 PE L Y++ D+WS G + E F Sbjct: 284 PEALNYGRYSSESDVWSFGILLWETF 309 >1ZXE-A nrPDB Length = 303 Score = 87.4 bits (215), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 77/259 (29%), Positives = 112/259 (43%), Gaps = 36/259 (13%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 S +E +A +G GA+G V KAR+ + A+K +R +ST+ +L L Sbjct: 6 SDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEE-------KLSTILSEVML--L 56 Query: 64 EAFEHPNVVRLMDVCATSR------TDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETI 117 + H VVR R T + K TL + + RT D L + Sbjct: 57 ASLNHQYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQRD 116 Query: 118 K--DLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM------ 169 + L RQ L L ++H+ I+HR+LKP NI + VK+ DFGLA+ + Sbjct: 117 EYWRLFRQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKLD 176 Query: 170 ---------ALTPVVVTLWYRAPEVLLQS-TYATPVDMWSVGCIFAEMFRRKPLFCGNSE 219 LT + T Y A EVL + Y +DM+S+G IF EM P G Sbjct: 177 SQNLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY--PFSTGMER 234 Query: 220 ADQLGKIFDL-IGLPPEDD 237 + L K+ + I PP+ D Sbjct: 235 VNILKKLRSVSIEFPPDFD 253 >1PHK-A nrPDB Length = 298 Score = 87.0 bits (214), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 86/306 (28%), Positives = 122/306 (39%), Gaps = 49/306 (16%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGG----LPISTVREVALLR 61 YEP +G G V + + A+K + V GG L +T++EV +LR Sbjct: 19 YEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDILR 78 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDL 120 ++ HPN+++L D T+ LVF+ + + +L YL + L + + + Sbjct: 79 KVSG--HPNIIQLKDTYETNTF-----FFLVFDLMKKGELFDYLTEKVT--LSEKETRKI 129 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY 180 MR L + LH IVHRDLKPENIL+ +KL DFG + L V T Y Sbjct: 130 MRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTPSY 189 Query: 181 RAPEVLLQST------YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD---LIG 231 APE++ S Y VDMWS G I + P F + L I G Sbjct: 190 LAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFG 249 Query: 232 LPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 P DD+ V L+ L P KR +A AL Sbjct: 250 SPEWDDYSDTVK--------------------------DLVSRFLVVQPQKRYTAEEALA 283 Query: 292 HSYLHK 297 H + + Sbjct: 284 HPFFQQ 289 >4KIK-B nrPDB Length = 677 Score = 87.0 bits (214), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 69/210 (32%), Positives = 95/210 (45%), Gaps = 19/210 (9%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVR---EVALLRR 62 +E +G G +G V + + +G +A+K R P + R E+ ++RR Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELS-------PRNRERWCLEIQIMRR 73 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ--DLRTYLDK-APPPGLPAETIKD 119 L HPNVV DV + + L+ Q DLR YL++ GL I Sbjct: 74 LT---HPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILT 130 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTV---KLADFGLARIYSYQMALTPVVV 176 L+ L +LH N I+HRDLKPENI++ G K+ D G A+ T V Sbjct: 131 LLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVG 190 Query: 177 TLWYRAPEVLLQSTYATPVDMWSVGCIFAE 206 TL Y APE+L Q Y VD WS G + E Sbjct: 191 TLQYLAPELLEQQKYTVTVDYWSFGTLAFE 220 >3H4J-B nrPDB Length = 336 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 80/279 (28%), Positives = 126/279 (45%), Gaps = 48/279 (17%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G G++G V A + VALK + + + RE++ L+ L HP++ Sbjct: 17 LGEGSFGKVKLATHYKTQQKVALKFI--SRQLLKKSDMHMRVEREISYLKLLR---HPHI 71 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFL 131 ++L DV T TD + +V E+ +L Y+ + + + +Q + +++ Sbjct: 72 IKLYDVITTP-TD----IVMVIEYAGGELFDYI--VEKKRMTEDEGRRFFQQIICAIEYC 124 Query: 132 HANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTY 191 H + IVHRDLKPEN+L+ VK+ADFGL+ I + L + Y APEV+ Y Sbjct: 125 HRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGKLY 184 Query: 192 ATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFP 250 A P VD+WS G + M L+G P DD F Sbjct: 185 AGPEVDVWSCGIVLYVM---------------------LVGRLPFDD----------EFI 213 Query: 251 PRGPRPVQS---VVPEMEESGAQ-LLLEMLTFNPHKRIS 285 P + V S V+P+ GAQ L+ M+ +P +RI+ Sbjct: 214 PNLFKKVNSCVYVMPDFLSPGAQSLIRRMIVADPMQRIT 252 >3UTO-A nrPDB Length = 573 Score = 86.3 bits (212), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 75/292 (25%), Positives = 122/292 (41%), Gaps = 38/292 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y+ E+G GA+G V++ + +G+ A K V P+ TVR+ ++ + Sbjct: 159 YDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDK------ETVRKE--IQTMSV 210 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 HP +V L D D E+ + F + D+ + + + MRQ Sbjct: 211 LRHPTLVNLHDAF---EDDNEMVMIYEFMSGGELFEKVADEHNK--MSEDEAVEYMRQVC 265 Query: 126 RGLDFLHANCIVHRDLKPENILVTS--GGTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183 +GL +H N VH DLKPENI+ T+ +KL DFGL + ++ T + AP Sbjct: 266 KGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAP 325 Query: 184 EVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 EV DMWSVG + + F G ++ + L + DW D S Sbjct: 326 EVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSC-------DWNMDDS 378 Query: 244 LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 G + E G + ++L +P+ R++ +AL+H +L Sbjct: 379 AFSG----------------ISEDGKDFIRKLLLADPNTRMTIHQALEHPWL 414 >4LG4-A nrPDB Length = 299 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 72/292 (24%), Positives = 131/292 (44%), Gaps = 42/292 (14%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 ++ + ++G G+YG+V+KA SG VA+K V V + ++E++++++ ++ Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQ-------EIIKEISIMQQCDS 65 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 P VV+ + + +V E+ + + + L + I +++ L Sbjct: 66 ---PYVVKYY-----GSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTL 117 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLWYRAPE 184 +GL++LH +HR++K NIL+ + G KLADFG+A + MA V+ T ++ APE Sbjct: 118 KGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 177 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244 V+ + Y D+WS+G EM KP + D+ Sbjct: 178 VIQEIGYNCVADIWSLGITSIEMAEGKPPYA-------------------------DIHP 212 Query: 245 PRGAFP-PRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 R F P P P + + + L NP +R +A + LQH ++ Sbjct: 213 MRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI 264 >1KOA-A nrPDB Length = 491 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 75/292 (25%), Positives = 122/292 (41%), Gaps = 38/292 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y+ E+G GA+G V++ + +G+ A K V P+ TVR+ ++ + Sbjct: 53 YDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDK------ETVRKE--IQTMSV 104 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 HP +V L D D E+ + F + D+ + + + MRQ Sbjct: 105 LRHPTLVNLHDAF---EDDNEMVMIYEFMSGGELFEKVADEHNK--MSEDEAVEYMRQVC 159 Query: 126 RGLDFLHANCIVHRDLKPENILVTS--GGTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183 +GL +H N VH DLKPENI+ T+ +KL DFGL + ++ T + AP Sbjct: 160 KGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAP 219 Query: 184 EVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 EV DMWSVG + + F G ++ + L + DW D S Sbjct: 220 EVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSC-------DWNMDDS 272 Query: 244 LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 G + E G + ++L +P+ R++ +AL+H +L Sbjct: 273 AFSG----------------ISEDGKDFIRKLLLADPNTRMTIHQALEHPWL 308 >4PDS-A nrPDB Length = 347 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 79/300 (26%), Positives = 136/300 (45%), Gaps = 53/300 (17%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G GA+ TV KA + +G ++K + G G+ RE+ +L++L HP + Sbjct: 39 VGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGV----TRELEVLQKLN---HPRI 91 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 VRL + + +V E V DL ++ A + + +++ RQ L + + Sbjct: 92 VRLKGFYEDTES-----YYMVMEFVSGGDLMDFV--AAHGAVGEDAGREISRQILTAIKY 144 Query: 131 LHANCIVHRDLKPENILVTSGG--TVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLL- 187 +H+ I HRDLKP+NIL+ VK+ FGLA++ + TL Y APEV+ Sbjct: 145 IHSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRG 204 Query: 188 ------------QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPE 235 ++ Y++ VDMWS+GC+ + F G+++ DQL K Sbjct: 205 KDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQ-DQLYK---------- 253 Query: 236 DDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 + RG++ GP + E + + +L +P+ R +A +AL H ++ Sbjct: 254 -------QIGRGSY-HEGPLKDFRISEEARD----FIDSLLQVDPNNRSTAAKALNHPWI 301 >6AO5-A nrPDB Length = 362 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 74/292 (25%), Positives = 132/292 (45%), Gaps = 42/292 (14%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 ++ + ++G G+YG+V+KA SG VA+K V V + ++E++++++ ++ Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQ-------EIIKEISIMQQCDS 64 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 P VV+ TD + +V E+ + + + L + I +++ L Sbjct: 65 ---PYVVKYYG-SYFKNTD----LWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTL 116 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLWYRAPE 184 +GL++LH +HR++K NIL+ + G KLADFG+A + MA V+ T ++ APE Sbjct: 117 KGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 176 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244 V+ + Y D+WS+G EM KP + D+ Sbjct: 177 VIQEIGYNCVADIWSLGITSIEMAEGKPPYA-------------------------DIHP 211 Query: 245 PRGAFP-PRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 R F P P P + + + L NP +R +A + LQH ++ Sbjct: 212 MRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFI 263 >6HXF-B nrPDB Length = 302 Score = 85.9 bits (211), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 65/216 (30%), Positives = 105/216 (48%), Gaps = 25/216 (11%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +E V E+G GA+G VYKA++ +G A K + + + + L Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEE--------ELEDYIVEIEILAT 72 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVF---EHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 +HP +V+L+ D ++ + + F VD + LD+ GL I+ + R Sbjct: 73 CDHPYIVKLL---GAYYHDGKLWIMIEFCPGGAVDA-IMLELDR----GLTEPQIQVVCR 124 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGL-ARIYSYQMALTPVVVTLWYR 181 Q L L+FLH+ I+HRDLK N+L+T G ++LADFG+ A+ + T ++ Sbjct: 125 QMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWM 184 Query: 182 APEVLLQST-----YATPVDMWSVGCIFAEMFRRKP 212 APEV++ T Y D+WS+G EM + +P Sbjct: 185 APEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEP 220 >2Z7Q-A nrPDB Length = 321 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 71/237 (29%), Positives = 110/237 (46%), Gaps = 21/237 (8%) Query: 4 SRYEPVAEIGVGAYGTVYKARD---PHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 S +E + +G G++G V+ R P SGH A+K ++ L + + Sbjct: 28 SHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKAT-------LKVRDRVRTKME 80 Query: 61 RRLEA-FEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIK 118 R + A HP VV+L T E K+ L+ + + DL T L K E +K Sbjct: 81 RDILADVNHPFVVKLHYAFQT-----EGKLYLILDFLRGGDLFTRLSKEVM--FTEEDVK 133 Query: 119 DLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYSYQMALTPVVVT 177 + + GLD LH+ I++RDLKPENIL+ G +KL DFGL++ ++ T Sbjct: 134 FYLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGT 193 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDL-IGLP 233 + Y APEV+ + ++ D WS G + EM F G + + I +G+P Sbjct: 194 VEYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP 250 >2X4F-A nrPDB Length = 373 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 82/291 (28%), Positives = 131/291 (45%), Gaps = 48/291 (16%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G G +G V+K + +G +A K ++ G E++++ +L+ H N+ Sbjct: 97 LGGGRFGQVHKCEETATGLKLAAKIIKTR-----GMKDKEEVKNEISVMNQLD---HANL 148 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 ++L D S+ D + LV E+VD +L + +TI M+Q G+ Sbjct: 149 IQLYDAFE-SKND----IVLVMEYVDGGELFDRIIDESYNLTELDTIL-FMKQICEGIRH 202 Query: 131 LHANCIVHRDLKPENILVTS--GGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQ 188 +H I+H DLKPENIL + +K+ DFGLAR Y + L T + APEV+ Sbjct: 203 MHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVNY 262 Query: 189 STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI----FDLIGLPPEDDWPRDVSL 244 + P DMWSVG I + F G+++A+ L I +DL ED+ +D+S Sbjct: 263 DFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDL-----EDEEFQDIS- 316 Query: 245 PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 E + + ++L RISA AL+H +L Sbjct: 317 ---------------------EEAKEFISKLLIKEKSWRISASEALKHPWL 346 >4APC-A nrPDB Length = 350 Score = 85.5 bits (210), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 65/267 (24%), Positives = 117/267 (43%), Gaps = 13/267 (4%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 + +Y + +IG G++G + G +K + + + REVA+L Sbjct: 22 SMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKERE---ESRREVAVLA 78 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDL 120 ++ HPN+V+ + + + + +V ++ + DL ++ + I D Sbjct: 79 NMK---HPNIVQYRESFEENGS-----LYIVMDYCEGGDLFKRINAQKGVLFQEDQILDW 130 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLW 179 Q L +H I+HRD+K +NI +T GTV+L DFG+AR+ + + L + T + Sbjct: 131 FVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPY 190 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 Y +PE+ Y D+W++GC+ E+ K F S + + KI P + Sbjct: 191 YLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYS 250 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEE 266 D+ R PR SV +E+ Sbjct: 251 YDLRSLVSQLFKRNPRDRPSVNSILEK 277 >4JXF-A nrPDB Length = 266 Score = 85.1 bits (209), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 63/222 (28%), Positives = 106/222 (47%), Gaps = 23/222 (10%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G G++ VY+A H+G VA+K + G+ EV + +L+ HP++ Sbjct: 15 LGKGSFAGVYRAESIHTGLEVAIK--MIDKKAMYKAGMVQRVQNEVKIHCQLK---HPSI 69 Query: 72 VRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 + L + S V LV E + ++ YL P E + M Q + G+ + Sbjct: 70 LELYNYFEDSNY-----VYLVLEMCHNGEMNRYLKNRVKPFSENEA-RHFMHQIITGMLY 123 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS------YQMALTPVVVTLWYRAPE 184 LH++ I+HRDL N+L+T +K+ADFGLA Y + TP Y +PE Sbjct: 124 LHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTP-----NYISPE 178 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI 226 + +S + D+WS+GC+F + +P F ++ + L K+ Sbjct: 179 IATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKV 220 >4L42-A nrPDB Length = 346 Score = 85.1 bits (209), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 68/240 (28%), Positives = 114/240 (47%), Gaps = 27/240 (11%) Query: 6 YEPVAEIGVGAYGTVYKARD---PHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 +E + +G G YG V++ R ++G A+K ++ + + ++ A + Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLK--------KAMIVRNAKDTAHTKA 71 Query: 63 ----LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAE-T 116 LE +HP +V L+ T K+ L+ E++ +L L++ G+ E T Sbjct: 72 ERNILEEVKHPFIVDLIYAFQTGG-----KLYLILEYLSGGELFMQLERE---GIFMEDT 123 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV 176 + + L LH I++RDLKPENI++ G VKL DFGL + + +T Sbjct: 124 ACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFC 183 Query: 177 -TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDL-IGLPP 234 T+ Y APE+L++S + VD WS+G + +M P F G + + KI + LPP Sbjct: 184 GTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPP 243 >2JAM-A nrPDB Length = 304 Score = 85.1 bits (209), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 78/297 (26%), Positives = 130/297 (43%), Gaps = 49/297 (16%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G GA+ V+ + +G ALK ++ S E+A+L++++ H N+ Sbjct: 17 LGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDS-----SLENEIAVLKKIK---HENI 68 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL-MRQFLRGLDF 130 V L D+ ++ LV + V D+ G+ E L ++Q L + + Sbjct: 69 VTLEDIYEST-----THYYLVMQLVSGG--ELFDRILERGVYTEKDASLVIQQVLSAVKY 121 Query: 131 LHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLL 187 LH N IVHRDLKPEN+L + + + DFGL+++ ++ T Y APEVL Sbjct: 122 LHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKM-EQNGIMSTACGTPGYVAPEVLA 180 Query: 188 QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRG 247 Q Y+ VD WS+G I + P F +E+ K+F+ I G Sbjct: 181 QKPYSKAVDCWSIGVITYILLCGYPPFYEETES----KLFEKI--------------KEG 222 Query: 248 AFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY------LHKD 298 + P ++ ES + +L +P++R + +AL H + LH+D Sbjct: 223 YYEFESP-----FWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRD 274 >4RLP-A nrPDB Length = 288 Score = 84.7 bits (208), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 68/240 (28%), Positives = 114/240 (47%), Gaps = 27/240 (11%) Query: 6 YEPVAEIGVGAYGTVYKARD---PHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 +E + +G G YG V++ R ++G A+K ++ + + ++ A + Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLK--------KAMIVRNAKDTAHTKA 58 Query: 63 ----LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAE-T 116 LE +HP +V L+ T K+ L+ E++ +L L++ G+ E T Sbjct: 59 ERNILEEVKHPFIVDLIYAFQTGG-----KLYLILEYLSGGELFMQLER---EGIFMEDT 110 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV 176 + + L LH I++RDLKPENI++ G VKL DFGL + + +T Sbjct: 111 ACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFC 170 Query: 177 -TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDL-IGLPP 234 T+ Y APE+L++S + VD WS+G + +M P F G + + KI + LPP Sbjct: 171 GTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPP 230 >4EQM-A nrPDB Length = 294 Score = 84.7 bits (208), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 70/230 (30%), Positives = 110/230 (47%), Gaps = 33/230 (14%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVA-L 59 + RY+ V ++G G TVY A D VA+K++ +P P RE Sbjct: 8 IINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIP---------P----REKEET 54 Query: 60 LRRLE-------AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPG 111 L+R E H N+V ++DV + + LV E+++ L Y++ P Sbjct: 55 LKRFEREVHNSSQLSHQNIVSMIDV-----DEEDDCYYLVMEYIEGPTLSEYIESHGP-- 107 Query: 112 LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL 171 L +T + Q L G+ H IVHRD+KP+NIL+ S T+K+ DFG+A+ S + +L Sbjct: 108 LSVDTAINFTNQILDGIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALS-ETSL 166 Query: 172 TP---VVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNS 218 T V+ T+ Y +PE D++S+G + EM +P F G + Sbjct: 167 TQTNHVLGTVQYFSPEQAKGEATDECTDIYSIGIVLYEMLVGEPPFNGET 216 >1KOB-A nrPDB Length = 387 Score = 84.0 bits (206), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 74/299 (24%), Positives = 128/299 (42%), Gaps = 40/299 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVR-EVALLRRLE 64 Y+ + E+G GA+G V++ + +G K + P L TV+ E++++ +L Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYP------LDKYTVKNEISIMNQLH 106 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 HP ++ L D + + ++ L+ E + A + + + MRQ Sbjct: 107 ---HPKLINLHDAF-----EDKYEMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQA 158 Query: 125 LRGLDFLHANCIVHRDLKPENILVTS--GGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 GL +H + IVH D+KPENI+ + +VK+ DFGLA + + T + A Sbjct: 159 CEGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAA 218 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 PE++ + DMW++G + + F G + + L + DW D Sbjct: 219 PEIVDREPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNV-------KRCDWEFD- 270 Query: 243 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGN 301 AF SV PE ++ + +L P KR++ AL+H +L D N Sbjct: 271 ---EDAF--------SSVSPEAKD----FIKNLLQKEPRKRLTVHDALEHPWLKGDHSN 314 >1LUF-A nrPDB Length = 343 Score = 84.0 bits (206), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 69/233 (29%), Positives = 101/233 (43%), Gaps = 43/233 (18%) Query: 7 EPVAEIGVGAYGTVYKARDP-----HSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 E V +IG GA+G V++AR P VA+K ++ + RE AL+ Sbjct: 50 EYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLK----EEASADMQADFQREAALMA 105 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFE-----------------------HVDQ 98 F++PN+V+L+ VCA + + L+FE H D Sbjct: 106 E---FDNPNIVKLLGVCAVGK-----PMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDL 157 Query: 99 DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLAD 158 R + PP L + RQ G+ +L VHRDL N LV VK+AD Sbjct: 158 STRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIAD 217 Query: 159 FGLAR-IYS--YQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 FGL+R IYS Y A + + + PE + + Y T D+W+ G + E+F Sbjct: 218 FGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIF 270 >2JC6-A nrPDB Length = 334 Score = 84.0 bits (206), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 64/202 (31%), Positives = 96/202 (47%), Gaps = 18/202 (8%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +E +G GA+ V A + +G A+K + P G I E+A+LR+++ Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCI--PKKALKGKESSIEN--EIAVLRKIK- 78 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAET-IKDLMRQF 124 H N+V L D+ + + LV + V D+ G E L+RQ Sbjct: 79 --HENIVALEDIYESPN-----HLYLVMQLVSGG--ELFDRIVEKGFYTEKDASTLIRQV 129 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSG---GTVKLADFGLARIYSYQMALTPVVVTLWYR 181 L + +LH IVHRDLKPEN+L S + ++DFGL+++ ++ T Y Sbjct: 130 LDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYV 189 Query: 182 APEVLLQSTYATPVDMWSVGCI 203 APEVL Q Y+ VD WS+G I Sbjct: 190 APEVLAQKPYSKAVDCWSIGVI 211 >4CZT-A nrPDB Length = 464 Score = 83.6 bits (205), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 78/304 (25%), Positives = 128/304 (42%), Gaps = 56/304 (18%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR-- 62 +YE +G G + V AR+ +G VA+K + + + +A ++R Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKE---------KVLKNKMIAQIKREI 62 Query: 63 --LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPG-LPAETIKD 119 ++ +HPNV+R+ +V A+ + K+ V E V DK G L + + Sbjct: 63 STMKLIKHPNVIRMFEVMAS-----KTKIYFVLEFVTGG--ELFDKISSNGRLKEDEARK 115 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI---YSYQMALTPVVV 176 +Q + +D+ H+ + HRDLKPEN+L+ + G +K++DFGL+ + L Sbjct: 116 YFQQLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCG 175 Query: 177 TLWYRAPEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG--LP 233 T Y APEV+ Y D+WS G I +F L+ LP Sbjct: 176 TPNYVAPEVINNKGYDGAKADLWSCGVI----------------------LFVLMAGYLP 213 Query: 234 PEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHS 293 ED SL + F P P S +L+ +L NP RI+ +++ Sbjct: 214 FED--SNLTSLYKKIFKAEFTCP-----PWFSASAKKLIKRILDPNPATRITFAEVIENE 266 Query: 294 YLHK 297 + K Sbjct: 267 WFKK 270 >6CCF-A nrPDB Length = 290 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 90/332 (27%), Positives = 137/332 (41%), Gaps = 78/332 (23%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVAL--------------------KSVRVP 40 M ++Y+ +EIG GAYG V A + A+ + + Sbjct: 2 MQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 61 Query: 41 NGGGGGGGLPISTV-REVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD 99 GG LP+ V +E+A+L++L+ H NVV+L++V D + LVF+ Sbjct: 62 QGGPAKQLLPLERVYQEIAILKKLD---HVNVVKLIEVLDDPAEDN---LYLVFD----- 110 Query: 100 LRTYLDKAPPPGLPA------ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGT 153 L K P +P E + +R + GL++LH IVHRD+KP N+L+ G Sbjct: 111 ---LLRKGPVMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGH 167 Query: 154 VKLADFGLARIYSYQMA-LTPVVVTLWYRAPEVLL---QSTYATPVDMWSVGCIFAEMFR 209 VK+ADFG++ + A L+ T + APE + QS +D+W+ G Sbjct: 168 VKIADFGVSNQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVT------ 221 Query: 210 RKPLFCGNSEADQLGKIFDLIGLPPEDDW----PRDVSLPRGAFPPRGPRPVQSVVPEME 265 L+C F P DD+ R + FP PE+ Sbjct: 222 ---LYC-----------FVYGKCPFIDDFILALHRKIKNEPVVFPEE---------PEIS 258 Query: 266 ESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 E L+L+ML NP RI H ++ K Sbjct: 259 EELKDLILKMLDKNPETRIGVPDIKLHPWVTK 290 >2A1A-B nrPDB Length = 284 Score = 83.2 bits (204), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 59/215 (27%), Positives = 95/215 (44%), Gaps = 24/215 (11%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 ++ + IG G +G V+KA+ G +K V+ N REV L +L+ Sbjct: 13 FKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNNE---------KAEREVKALAKLD- 62 Query: 66 FEHPNVVRL--------MDVCATSRTDREIKVTLVF---EHVDQ-DLRTYLDKAPPPGLP 113 H N+V D +S+ K +F E D+ L +++K L Sbjct: 63 --HVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKLD 120 Query: 114 AETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTP 173 +L Q +G+D++H+ +++RDLKP NI + VK+ DFGL T Sbjct: 121 KVLALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRTR 180 Query: 174 VVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 TL Y +PE + Y VD++++G I AE+ Sbjct: 181 SKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL 215 >2F57-A nrPDB Length = 317 Score = 83.2 bits (204), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 72/239 (30%), Positives = 115/239 (48%), Gaps = 19/239 (7%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +IG G+ G V A + H+G VA+K + + EV ++R + H N Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRE-----LLFNEVVIMR---DYHHDN 103 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 VV D+ ++ E+ V V E ++ T D + E I + LR L + Sbjct: 104 VV---DMYSSYLVGDELWV--VMEFLEGGALT--DIVTHTRMNEEQIATVCLSVLRALSY 156 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPEVLLQS 189 LH ++HRD+K ++IL+TS G +KL+DFG S ++ +V T ++ APEV+ + Sbjct: 157 LHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRL 216 Query: 190 TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPE-DDWPRDVSLPRG 247 Y T VD+WS+G + EM +P + + +I D LPP D + S+ RG Sbjct: 217 PYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRD--SLPPRVKDLHKVSSVLRG 273 >3TAC-A nrPDB Length = 361 Score = 83.2 bits (204), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 81/297 (27%), Positives = 123/297 (41%), Gaps = 39/297 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 YE IG G + V + + +G A+K V V G RE ++ L+ Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLK- 86 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGL--PAETIKDLMR 122 HP++V L++ ++ + +VFE +D DL + K G MR Sbjct: 87 --HPHIVELLETYSSDGM-----LYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMR 139 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLA-RIYSYQMALTPVVVTL 178 Q L L + H N I+HRD+KP +L+ S VKL FG+A ++ + V T Sbjct: 140 QILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTP 199 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 + APEV+ + Y PVD+W G I + F G E ++F+ I Sbjct: 200 HFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKE-----RLFEGIIKGKYKMN 254 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 PR S + ES L+ ML +P +RI+ + AL H +L Sbjct: 255 PRQWS-------------------HISESAKDLVRRMLMLDPAERITVYEALNHPWL 292 >2BRG-A nrPDB Length = 297 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 97/207 (46%), Gaps = 17/207 (8%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 ++ V +G GAYG V A + + VA+K V + P + +E+ + + L Sbjct: 9 WDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVD----CPENIKKEICINKMLN- 63 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 H NVV+ RE + +F + P G+P + Q + Sbjct: 64 --HENVVKFYG------HRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLM 115 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY---QMALTPVVVTLWYRA 182 G+ +LH I HRD+KPEN+L+ +K++DFGLA ++ Y + L + TL Y A Sbjct: 116 AGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVA 175 Query: 183 PEVLLQSTY-ATPVDMWSVGCIFAEMF 208 PE+L + + A PVD+WS G + M Sbjct: 176 PELLKRREFHAEPVDVWSCGIVLTAML 202 >4UZD-A nrPDB Length = 287 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 59/215 (27%), Positives = 99/215 (46%), Gaps = 12/215 (5%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G G +G VY AR+ S +ALK + G+ REV + L HPN+ Sbjct: 16 LGKGKFGNVYLAREKQSKFILALKVLF--KAQLEKAGVEHQLRREVEIQSHLR---HPNI 70 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFL 131 +RL + +V L+ E+ Y + + + + L + Sbjct: 71 LRLYGYFHDA-----TRVYLILEYAPLGT-VYRELQKLSKFDEQRTATYITELANALSYC 124 Query: 132 HANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTY 191 H+ ++HRD+KPEN+L+ S G +K+ADFG + +++ T + TL Y PE++ + Sbjct: 125 HSKRVIHRDIKPENLLLGSAGELKIADFGWS-VHAPSSRRTTLCGTLDYLPPEMIEGRMH 183 Query: 192 ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI 226 VD+WS+G + E KP F N+ + +I Sbjct: 184 DEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRI 218 >4M7I-A nrPDB Length = 299 Score = 82.0 bits (201), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 62/225 (27%), Positives = 104/225 (46%), Gaps = 29/225 (12%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +EP+ +G G +G V++A++ A+K +R+PN +REV L +LE Sbjct: 7 FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELARE----KVMREVKALAKLE- 61 Query: 66 FEHPNVVRLMDVCATSRTDREI-----KVTLVFEHV---DQDLRTYLD-KAPPPGLPAET 116 HP +VR + T ++ KV L + ++L+ +++ + Sbjct: 62 --HPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSV 119 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY----QMALT 172 + Q ++FLH+ ++HRDLKP NI T VK+ DFGL Q LT Sbjct: 120 CLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLT 179 Query: 173 PV---------VVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 P+ V T Y +PE + ++Y+ VD++S+G I E+ Sbjct: 180 PMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL 224 >4YNZ-A nrPDB Length = 342 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 54/171 (31%), Positives = 84/171 (49%), Gaps = 12/171 (7%) Query: 36 SVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEH 95 ++++ N + + RE+A+L+ EHP+V++L DV + + LV EH Sbjct: 39 AIKIVNREKLSESVLMKVEREIAILK---LIEHPHVLKLHDVYENKKY-----LYLVLEH 90 Query: 96 VDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTV 154 V +L YL K L + + RQ + LDF H++ I HRDLKPEN+L+ + Sbjct: 91 VSGGELFDYLVKKGR--LTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLLDERNNI 148 Query: 155 KLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTY-ATPVDMWSVGCIF 204 ++ADFG+A + L + Y PEV+ Y D+WS G I Sbjct: 149 RIADFGMASLQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWSCGVIL 199 >5YV8-A nrPDB Length = 298 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 67/237 (28%), Positives = 118/237 (49%), Gaps = 34/237 (14%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVR----VPNGG------------GGGG 47 ++Y EIG G+YG V A + + + A+K + + G GG Sbjct: 13 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 72 Query: 48 GL----PISTV-REVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRT 102 + PI V +E+A+L++L+ HPNVV+L++V D + +VFE V+Q Sbjct: 73 CIQPRGPIEQVYQEIAILKKLD---HPNVVKLVEVLDDPNEDH---LYMVFELVNQGPVM 126 Query: 103 YLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLA 162 + P L + + + ++G+++LH I+HRD+KP N+LV G +K+ADFG++ Sbjct: 127 EVPTLKP--LSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVS 184 Query: 163 RIYSYQMA-LTPVVVTLWYRAPEVLLQST---YATPVDMWSVGC-IFAEMFRRKPLF 214 + A L+ V T + APE L ++ +D+W++G ++ +F + P Sbjct: 185 NEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFM 241 >6DBN-A nrPDB Length = 316 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 68/233 (29%), Positives = 108/233 (46%), Gaps = 27/233 (11%) Query: 9 VAEIGVGAYGTVYKAR-DP---HSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 + ++G G +G V R DP ++G VA+KS++ +GG L +E+ +LR L Sbjct: 40 IRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLK----KEIEILRNLY 95 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQ 123 H N+V+ +C D + L+ E + L+ YL K + +K + Q Sbjct: 96 ---HENIVKYKGICTE---DGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAV-Q 148 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-----TL 178 +G+D+L + VHRDL N+LV S VK+ DFGL + V Sbjct: 149 ICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVF 208 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG 231 WY APE L+QS + D+WS G E+ +C +S++ + +IG Sbjct: 209 WY-APECLMQSKFYIASDVWSFGVTLHELL----TYC-DSDSSPMALFLKMIG 255 >4AN9-A nrPDB Length = 301 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 62/204 (30%), Positives = 97/204 (47%), Gaps = 17/204 (8%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +E ++E+G G G V+K SG +A K + L I ++R L+ Sbjct: 11 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIH----------LEIKPAIRNQIIRELQV 60 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQF 124 N ++ +D EI + + EH+D L L KA +P + + + Sbjct: 61 LHECNSPYIVGFYGAFYSDGEISICM--EHMDGGSLDQVLKKAGR--IPEQILGKVSIAV 116 Query: 125 LRGLDFL-HANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183 ++GL +L + I+HRD+KP NILV S G +KL DFG++ +MA V T Y +P Sbjct: 117 IKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMA-NEFVGTRSYMSP 175 Query: 184 EVLLQSTYATPVDMWSVGCIFAEM 207 E L + Y+ D+WS+G EM Sbjct: 176 ERLQGTHYSVQSDIWSMGLSLVEM 199 >2UV2-A nrPDB Length = 325 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 62/213 (29%), Positives = 103/213 (48%), Gaps = 19/213 (8%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +E + E+G GA+G VYKA++ + A K + + + E+ +L + Sbjct: 39 WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-----EIDILA---S 90 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 +HPN+V+L+D + + + + F L+ P L I+ + +Q L Sbjct: 91 CDHPNIVKLLDAF---YYENNLWILIEFCAGGAVDAVMLELERP--LTESQIQVVCKQTL 145 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLWYRAPE 184 L++LH N I+HRDLK NIL T G +KLADFG++ + + + T ++ APE Sbjct: 146 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 205 Query: 185 VLLQST-----YATPVDMWSVGCIFAEMFRRKP 212 V++ T Y D+WS+G EM +P Sbjct: 206 VVMCETSKDRPYDYKADVWSLGITLIEMAEIEP 238 >6CQF-A nrPDB Length = 297 Score = 81.3 bits (199), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 66/225 (29%), Positives = 102/225 (45%), Gaps = 46/225 (20%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRV-PNGGGGGGGLPISTVREVALLRRLE 64 Y+ + +G G YG V+KARD SG VALK V++ P+ +ST+++ L+ L+ Sbjct: 18 YDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDD-------DVSTLQKEILI--LK 68 Query: 65 AFEHPNVVR-------------LMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPG 111 H N+V M+ C +VT Sbjct: 69 TCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVT-------------------GS 109 Query: 112 LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGL-ARIYSYQMA 170 L I + R+ L+GL +LH+ +HRD+K NIL+ G V+LADFG+ A+I + Sbjct: 110 LSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLAR 169 Query: 171 LTPVVVTLWYRAPE---VLLQSTYATPVDMWSVGCIFAEMFRRKP 212 + T ++ APE V L+ Y D+WS+G E+ +P Sbjct: 170 RLAFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQP 214 >5J5T-A nrPDB Length = 370 Score = 81.3 bits (199), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 84/299 (28%), Positives = 134/299 (44%), Gaps = 50/299 (16%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +E + IG G YG VYKAR+ ++G A+K +++ G + V++ ++ ++ Sbjct: 6 FELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGED------FAVVQQEIIM--MKD 57 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVD----QDLRTYLDKAPPPGLPAETIKDLM 121 +HPN+V R K+ + E QD+ Y P L I + Sbjct: 58 CKHPNIVAYFGSYL-----RRDKLWICMEFCGGGSLQDI--YHVTGP---LSELQIAYVS 107 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGL-ARIYSYQMALTPVVVTLWY 180 R+ L+GL +LH+ +HRD+K NIL+T G VKLADFG+ A+I + + T ++ Sbjct: 108 RETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYW 167 Query: 181 RAPEVLL---QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 APEV + Y D+W+VG E+ +P +FDL + Sbjct: 168 MAPEVAAVERKGGYNQLCDLWAVGITAIELAELQP------------PMFDLHPM----- 210 Query: 238 WPRDVSL-PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 R + L + F P P + S + LT NP KR +A + LQH ++ Sbjct: 211 --RALFLMTKSNFQP----PKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFV 263 >5KKR-C nrPDB Length = 395 Score = 80.9 bits (198), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 62/204 (30%), Positives = 96/204 (47%), Gaps = 17/204 (8%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +E ++E+G G G V+K SG +A K + L I ++R L+ Sbjct: 70 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIH----------LEIKPAIRNQIIRELQV 119 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQF 124 N ++ +D EI + + EH+D L L KA +P + + + Sbjct: 120 LHECNSPYIVGFYGAFYSDGEISICM--EHMDGGSLDQVLKKAGR--IPEQILGKVSIAV 175 Query: 125 LRGLDFL-HANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183 ++GL +L + I+HRD+KP NILV S G +KL DFG++ MA V T Y +P Sbjct: 176 IKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYMSP 234 Query: 184 EVLLQSTYATPVDMWSVGCIFAEM 207 E L + Y+ D+WS+G EM Sbjct: 235 ERLQGTHYSVQSDIWSMGLSLVEM 258 >3DLS-A nrPDB Length = 335 Score = 80.9 bits (198), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 63/228 (27%), Positives = 106/228 (46%), Gaps = 34/228 (14%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRV-----------PNGGGGGGGLPI 51 + +Y ++ +G GA+G V+ A D V +K ++ P G Sbjct: 23 SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLG-------- 74 Query: 52 STVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ--DLRTYLDKAPP 109 E+A+L R+E H N+++++D+ + + LV E DL ++D+ P Sbjct: 75 KVTLEIAILSRVE---HANIIKVLDI-----FENQGFFQLVMEKHGSGLDLFAFIDRHPR 126 Query: 110 PGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM 169 P + + RQ + + +L I+HRD+K ENI++ T+KL DFG A Sbjct: 127 LDEPLASY--IFRQLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGK 184 Query: 170 ALTPVVVTLWYRAPEVLLQSTYATP-VDMWSVGC-IFAEMFRRKPLFC 215 T+ Y APEVL+ + Y P ++MWS+G ++ +F P FC Sbjct: 185 LFYTFCGTIEYCAPEVLMGNPYRGPELEMWSLGVTLYTLVFEENP-FC 231 >6E2O-A nrPDB Length = 295 Score = 80.9 bits (198), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 64/209 (30%), Positives = 99/209 (47%), Gaps = 19/209 (9%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G G YG VY RD + +A+K + + P+ E+AL + L+ H N+ Sbjct: 30 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYS---QPLH--EEIALHKHLK---HKNI 81 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYL--DKAPPPGLPAETIKDLMRQFLRGLD 129 V+ + + + + + E V + L K P +TI +Q L GL Sbjct: 82 VQYLGSFSENGF-----IKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLK 136 Query: 130 FLHANCIVHRDLKPENILV-TSGGTVKLADFGLA-RIYSYQMALTPVVVTLWYRAPEVLL 187 +LH N IVHRD+K +N+L+ T G +K++DFG + R+ TL Y APE++ Sbjct: 137 YLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIID 196 Query: 188 QS--TYATPVDMWSVGCIFAEMFRRKPLF 214 + Y D+WS+GC EM KP F Sbjct: 197 KGPRGYGKAADIWSLGCTIIEMATGKPPF 225 >5JZN-A nrPDB Length = 280 Score = 80.9 bits (198), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 82/305 (26%), Positives = 133/305 (43%), Gaps = 54/305 (17%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 T RY+ IG G + V + + + ALK ++ G + EV++LRR Sbjct: 18 TERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHMIQ----NEVSILRR 73 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ----DLRTYLDKAPPPGLPAETIK 118 ++ HPN+V L++ D ++ LV E V D T +K Sbjct: 74 VK---HPNIVLLIE-----EMDVPTELYLVMELVKGGDLFDAITSTNKYTERDASG---- 121 Query: 119 DLMRQFLRGLDFLHANCIVHRDLKPENILV----TSGGTVKLADFGLARIYS---YQMAL 171 ++ + +LH+ IVHRD+KPEN+LV ++KL DFGLA I Y + Sbjct: 122 -MLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYTVCG 180 Query: 172 TPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG 231 TP Y APE++ ++ Y VD+W+ G I + P F G+ + ++ +FD I Sbjct: 181 TPT-----YVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEV--LFDQIL 233 Query: 232 LPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 + D P P V +S +L+ ML + +R SA + L+ Sbjct: 234 MGQVD----------------FPSPYWDNVS---DSAKELITMMLLVDVDQRFSAVQVLE 274 Query: 292 HSYLH 296 H +++ Sbjct: 275 HPWVN 279 >3EQC-A nrPDB Length = 360 Score = 80.9 bits (198), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 62/204 (30%), Positives = 96/204 (47%), Gaps = 17/204 (8%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +E ++E+G G G V+K SG +A K + L I ++R L+ Sbjct: 35 FEKISELGAGNGGVVFKVSHKPSGLVMARKLIH----------LEIKPAIRNQIIRELQV 84 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQF 124 N ++ +D EI + + EH+D L L KA +P + + + Sbjct: 85 LHECNSPYIVGFYGAFYSDGEISICM--EHMDGGSLDQVLKKAGR--IPEQILGKVSIAV 140 Query: 125 LRGLDFL-HANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183 ++GL +L + I+HRD+KP NILV S G +KL DFG++ MA V T Y +P Sbjct: 141 IKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYMSP 199 Query: 184 EVLLQSTYATPVDMWSVGCIFAEM 207 E L + Y+ D+WS+G EM Sbjct: 200 ERLQGTHYSVQSDIWSMGLSLVEM 223 >3QA8-A nrPDB Length = 676 Score = 80.9 bits (198), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 67/212 (31%), Positives = 94/212 (44%), Gaps = 23/212 (10%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +E +G G +G V + +G VA+K R P + R ++ ++ Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELS-------PKNRERWCLEIQIMKK 68 Query: 66 FEHPNVVRLMDVCATSRTDREIKVT------LVFEHVDQ-DLRTYLDK-APPPGLPAETI 117 HPNVV +V D K+ L E+ + DLR YL++ GL I Sbjct: 69 LNHPNVVSAREV-----PDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPI 123 Query: 118 KDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTV---KLADFGLARIYSYQMALTPV 174 + L+ L +LH N I+HRDLKPENI++ G K+ D G A+ T Sbjct: 124 RTLLSDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEF 183 Query: 175 VVTLWYRAPEVLLQSTYATPVDMWSVGCIFAE 206 V TL Y APE+L Q Y VD WS G + E Sbjct: 184 VGTLQYLAPELLEQKKYTVTVDYWSFGTLAFE 215 >5D7A-A nrPDB Length = 308 Score = 80.5 bits (197), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 63/218 (28%), Positives = 96/218 (44%), Gaps = 16/218 (7%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +E V +G G YG VYK R +G A+K + V G +E+ +L++ Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT------GDEEEEIKQEINMLKKYS- 71 Query: 66 FEHPNVVRLMDVCATSRT-DREIKVTLVFEHVDQDLRTYLDKAPPPG-LPAETIKDLMRQ 123 H N+ + ++ LV E T L K L E I + R+ Sbjct: 72 -HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICRE 130 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLWYRA 182 LRGL LH + ++HRD+K +N+L+T VKL DFG++ + + T ++ A Sbjct: 131 ILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMA 190 Query: 183 PEVLL-----QSTYATPVDMWSVGCIFAEMFRRKPLFC 215 PEV+ +TY D+WS+G EM P C Sbjct: 191 PEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLC 228 >4CSV-A nrPDB Length = 275 Score = 80.5 bits (197), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 53/202 (26%), Positives = 101/202 (50%), Gaps = 19/202 (9%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPIST-VREVALLRRLEAFEHP 69 ++G G +G VY+ + + VA+K+++ G + + ++E ++++L+ HP Sbjct: 18 KLGSGQFGEVYEGKWRNYNIEVAVKTLK-------EGTMSVEEFLQEAQIMKKLK---HP 67 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 N+V+L VC +E + ++ E++ L YL + A+ + D+ Q G+ Sbjct: 68 NLVQLYGVCT-----KEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVASGM 122 Query: 129 DFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ--MALTPVVVTLWYRAPEVL 186 +L + +HRDL N LV VK+ADFGLAR+ + A + + APE + Sbjct: 123 AYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTAPEAI 182 Query: 187 LQSTYATPVDMWSVGCIFAEMF 208 + ++ D+W+ G + E+F Sbjct: 183 SYNRFSIKSDVWAFGILLWEIF 204 >3HKO-A nrPDB Length = 345 Score = 80.5 bits (197), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 82/340 (24%), Positives = 136/340 (40%), Gaps = 81/340 (23%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 +Y IG G+YG V A + + A++++++ N P R +R ++ Sbjct: 27 KYHLKGAIGQGSYGVVRVAIENQTR---AIRAIKIMNKNKIRQINPKDVERIKTEVRLMK 83 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFE-----HVDQDLRTYLDKA------------ 107 HPN+ RL +V + E + LV E H+ L ++D + Sbjct: 84 KLHHPNIARLYEV-----YEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQ 138 Query: 108 --PPPGLPAETIK--------------------DLMRQFLRGLDFLHANCIVHRDLKPEN 145 P P E I ++MRQ L +LH I HRD+KPEN Sbjct: 139 ICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPEN 198 Query: 146 ILVTSGGT--VKLADFGLARIYSYQM------ALTPVVVTLWYRAPEVL--LQSTYATPV 195 L ++ + +KL DFGL++ + Y++ +T T ++ APEVL +Y Sbjct: 199 FLFSTNKSFEIKLVDFGLSKEF-YKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKC 257 Query: 196 DMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR 255 D WS G + + F G ++AD + ++ + + F Sbjct: 258 DAWSAGVLLHLLLMGAVPFPGVNDADTISQVLN----------------KKLCF----EN 297 Query: 256 PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 P +V+ + LL +L N +R A RALQH ++ Sbjct: 298 PNYNVLSPL---ARDLLSNLLNRNVDERFDAMRALQHPWI 334 >1S9I-A nrPDB Length = 354 Score = 80.1 bits (196), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 64/204 (31%), Positives = 96/204 (47%), Gaps = 17/204 (8%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +E ++E+G G G V K + SG +A K + L I ++R L+ Sbjct: 18 FERISELGAGNGGVVTKVQHRPSGLIMARKLIH----------LEIKPAIRNQIIRELQV 67 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQF 124 N ++ +D EI + + EH+D L L +A +P E + + Sbjct: 68 LHECNSPYIVGFYGAFYSDGEISICM--EHMDGGSLDQVLKEAKR--IPEEILGKVSIAV 123 Query: 125 LRGLDFL-HANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183 LRGL +L + I+HRD+KP NILV S G +KL DFG++ MA V T Y AP Sbjct: 124 LRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTRSYMAP 182 Query: 184 EVLLQSTYATPVDMWSVGCIFAEM 207 E L + Y+ D+WS+G E+ Sbjct: 183 ERLQGTHYSVQSDIWSMGLSLVEL 206 >1FOT-A nrPDB Length = 318 Score = 79.7 bits (195), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 61/227 (26%), Positives = 107/227 (47%), Gaps = 40/227 (17%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 ++ + +G G++G V+ R H+G + A+K ++ +E+ + RL+ Sbjct: 8 FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLK----------------KEIVV--RLKQ 49 Query: 66 FEHPNVVRLMDVCAT---------SRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAE 115 EH N RLM T + D + ++ ++ ++++ +L + L K+ P Sbjct: 50 VEHTNDERLMLSIVTHPFIIRMWGTFQDAQ-QIFMIMDYIEGGELFSLLRKSQ--RFPNP 106 Query: 116 TIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI---YSYQMALT 172 K + L++LH+ I++RDLKPENIL+ G +K+ DFG A+ +Y + T Sbjct: 107 VAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPDVTYTLCGT 166 Query: 173 PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNS 218 P Y APEV+ Y +D WS G + EM P + N+ Sbjct: 167 PD-----YIAPEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNT 208 >4PWN-A nrPDB Length = 274 Score = 79.7 bits (195), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 61/203 (30%), Positives = 97/203 (47%), Gaps = 18/203 (8%) Query: 11 EIGVGAYGTVYKARDPHSGHFVA---LKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 EIG G++ TVYK D + VA L+ ++ +E A + L+ + Sbjct: 17 EIGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKS-------ERQRFKEEAEM--LKGLQ 67 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 HPN+VR D ++ ++ V + L+TYL + + + ++ RQ L+G Sbjct: 68 HPNIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKV--MKIKVLRSWCRQILKG 125 Query: 128 LDFLHANC--IVHRDLKPENILVTS-GGTVKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 L FLH I+HRDLK +NI +T G+VK+ D GLA + V+ T + APE Sbjct: 126 LQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPE 185 Query: 185 VLLQSTYATPVDMWSVGCIFAEM 207 + + Y VD+++ G EM Sbjct: 186 -MYEEKYDESVDVYAFGMCMLEM 207 >3D2K-A nrPDB Length = 272 Score = 79.7 bits (195), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 70/292 (23%), Positives = 124/292 (42%), Gaps = 41/292 (14%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G G +G VY AR+ S +ALK + G + REV + L HPN+ Sbjct: 20 LGKGKFGNVYLARERQSKFILALKVLFKTQLEKAG--VEHQLRREVEIQSHLR---HPNI 74 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFL 131 +RL + +V L+ E+ Y + + + + L + Sbjct: 75 LRLYGYFHDA-----TRVYLILEYAPLGT-VYRELQKLSRFDEQRTATYITELANALSYC 128 Query: 132 HANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTY 191 H+ ++HRD+KPEN+L+ S G +K+ADFG + +++ T + TL Y PE++ + Sbjct: 129 HSKRVIHRDIKPENLLLGSNGELKIADFGWS-VHAPSSRRTTLCGTLDYLPPEMIEGRMH 187 Query: 192 ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPP 251 VD+WS+G + E L+G+PP + + R + Sbjct: 188 DEKVDLWSLGVLCYEF---------------------LVGMPPFEAHTYQETYRRIS--- 223 Query: 252 RGPRPVQSVVPEMEESGAQ-LLLEMLTFNPHKRISAFRALQHSYLHKDEGNP 302 V+ P+ GA+ L+ +L N +R++ L+H ++ + P Sbjct: 224 ----RVEFTFPDFVTEGARDLISRLLKHNASQRLTLAEVLEHPWIKANSSKP 271 >4FZF-B nrPDB Length = 283 Score = 79.7 bits (195), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 55/208 (26%), Positives = 102/208 (49%), Gaps = 15/208 (7%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 + + IG G++G V+K D + VA+K + + +E+ +L + ++ Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAED----EIEDIQQEITVLSQCDS 65 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 V + K+ ++ E++ L +A P I ++++ L Sbjct: 66 ---SYVTKYYGSYLKGS-----KLWIIMEYLGGGSALDLLRAGP--FDEFQIATMLKEIL 115 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLA-RIYSYQMALTPVVVTLWYRAPE 184 +GLD+LH+ +HRD+K N+L++ G VKLA FG+A ++ Q+ V T ++ APE Sbjct: 116 KGLDYLHSEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPE 175 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKP 212 V+ QS Y + D+WS+G E+ + +P Sbjct: 176 VIQQSAYDSKADIWSLGITAIELAKGEP 203 >5ES1-A nrPDB Length = 328 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 58/201 (28%), Positives = 93/201 (46%), Gaps = 15/201 (7%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y + IG G + V AR +G VA+K + P S + +R ++ Sbjct: 17 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN------PSSLQKLFREVRIMKG 70 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQF 124 HPN+V+L +V T +T + LV E+ ++ YL + + + RQ Sbjct: 71 LNHPNIVKLFEVIETEKT-----LYLVMEYASAGEVFDYL--VSHGRMKEKEARAKFRQI 123 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 + + + H IVHRDLK EN+L+ + +K+ADFG + ++ L + Y APE Sbjct: 124 VSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPE 183 Query: 185 VLLQSTYATP-VDMWSVGCIF 204 + Y P VD+WS+G I Sbjct: 184 LFQGKKYDGPEVDIWSLGVIL 204 >4C59-A nrPDB Length = 340 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 68/245 (27%), Positives = 113/245 (46%), Gaps = 34/245 (13%) Query: 15 GAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRL 74 G + VY+A+D SG ALK + + N + ++EV +++L HPN+V+ Sbjct: 38 GGFAFVYEAQDVGSGREYALKRL-LSNEEEKNRAI----IQEVCFMKKLSG--HPNIVQF 90 Query: 75 MDVCATSRTDREI---KVTLVFEHVDQDLRTYLDKAPPPG-LPAETIKDLMRQFLRGLDF 130 + + + + + L+ E L +L K G L +T+ + Q R + Sbjct: 91 CSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKIFYQTCRAVQH 150 Query: 131 LHANC--IVHRDLKPENILVTSGGTVKLADFGLARI------YSYQMALTPVV------- 175 +H I+HRDLK EN+L+++ GT+KL DFG A YS+ +V Sbjct: 151 MHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRRALVEEEITRN 210 Query: 176 VTLWYRAPEVL-LQSTY--ATPVDMWSVGCI-FAEMFRRKPLFCGNSEADQLGKIFDLIG 231 T YR PE++ L S + D+W++GCI + FR+ P + +L + Sbjct: 211 TTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPF----EDGAKLRIVNGKYS 266 Query: 232 LPPED 236 +PP D Sbjct: 267 IPPHD 271 >5KZ7-A nrPDB Length = 346 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 59/201 (29%), Positives = 95/201 (47%), Gaps = 15/201 (7%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y + IG G + V AR +G VA V++ + REV +++ L Sbjct: 35 YRLLKTIGKGNFAKVKLARHILTGKEVA---VKIIDKTQLNSSSLQKLFREVRIMKVLN- 90 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQF 124 HPN+V+L +V T +T + LV E+ ++ YL + + + RQ Sbjct: 91 --HPNIVKLFEVIETEKT-----LYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQI 141 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 + + + H IVHRDLK EN+L+ + +K+ADFG + +++ L + Y APE Sbjct: 142 VSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPE 201 Query: 185 VLLQSTYATP-VDMWSVGCIF 204 + Y P VD+WS+G I Sbjct: 202 LFQGKKYDGPEVDVWSLGVIL 222 >6FDY-U nrPDB Length = 276 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 68/219 (31%), Positives = 101/219 (46%), Gaps = 17/219 (7%) Query: 12 IGVGAYGTVYKAR-DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +G G Y TVYKA + VA+K V + + + E+ +L+ HP+ Sbjct: 19 LGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVE---NLLTEIEILK---GIRHPH 72 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 +V+L D S + L+ E DL ++ LP + + M+Q L Sbjct: 73 IVQLKDFQWDSDN-----IYLIMEFCAGGDLSRFIHTRRI--LPEKVARVFMQQLASALQ 125 Query: 130 FLHANCIVHRDLKPENILVTS--GGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLL 187 FLH I H DLKP+NIL++S +KLADFG A+ S + + Y APE++ Sbjct: 126 FLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVC 185 Query: 188 QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI 226 Q Y VD+WS+G I E +P F S ++ KI Sbjct: 186 QRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKI 224 >4U41-A nrPDB Length = 332 Score = 79.0 bits (193), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 97/217 (44%), Gaps = 14/217 (6%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +E V +G G YG VYK R +G A+K + V L I+ +++ + R + Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIAT 85 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPG-LPAETIKDLMRQF 124 + + + S + ++ LV E T L K L + I + R+ Sbjct: 86 YYGAFIKK-------SPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREI 138 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLWYRAP 183 LRGL LH + ++HRD+K +N+L+T VKL DFG++ + + T ++ AP Sbjct: 139 LRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAP 198 Query: 184 EVLL-----QSTYATPVDMWSVGCIFAEMFRRKPLFC 215 EV+ +TY D+WS G EM P C Sbjct: 199 EVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLC 235 >2QNJ-A nrPDB Length = 328 Score = 79.0 bits (193), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 57/201 (28%), Positives = 93/201 (46%), Gaps = 15/201 (7%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y + IG G + V AR +G VA+K + P S + +R ++ Sbjct: 14 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN------PTSLQKLFREVRIMKI 67 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQF 124 HPN+V+L +V T +T + L+ E+ ++ YL + + + RQ Sbjct: 68 LNHPNIVKLFEVIETEKT-----LYLIMEYASGGEVFDYL--VAHGRMKEKEARSKFRQI 120 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 + + + H IVHRDLK EN+L+ + +K+ADFG + ++ L + Y APE Sbjct: 121 VSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPE 180 Query: 185 VLLQSTYATP-VDMWSVGCIF 204 + Y P VD+WS+G I Sbjct: 181 LFQGKKYDGPEVDVWSLGVIL 201 >3KA0-A nrPDB Length = 320 Score = 78.6 bits (192), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 77/297 (25%), Positives = 125/297 (42%), Gaps = 38/297 (12%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVR-VPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +G+G G V + + + ALK ++ P REV L R A + P+ Sbjct: 24 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR-----------REVELHWR--ASQCPH 70 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 +VR++DV R+ + +V E +D +L + + ++M+ + Sbjct: 71 IVRIVDVYENLYAGRKC-LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 129 Query: 130 FLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVL 186 +LH+ I HRD+KPEN+L TS +KL DFG A+ + +LT T +Y APEVL Sbjct: 130 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPYYVAPEVL 189 Query: 187 LQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPR 246 Y DMWS+G I + P F N GL + + + Sbjct: 190 GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------------GLAISPGMKTRIRMGQ 237 Query: 247 GAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 303 F P P S E+ E L+ +L P +R++ + H ++ + P+ Sbjct: 238 YEF----PNPEWS---EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 287 >2OZA-A nrPDB Length = 356 Score = 78.2 bits (191), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 77/297 (25%), Positives = 125/297 (42%), Gaps = 38/297 (12%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVR-VPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +G+G G V + + + ALK ++ P REV L R A + P+ Sbjct: 26 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR-----------REVELHWR--ASQCPH 72 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 +VR++DV R+ + +V E +D +L + + ++M+ + Sbjct: 73 IVRIVDVYENLYAGRKC-LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 131 Query: 130 FLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVL 186 +LH+ I HRD+KPEN+L TS +KL DFG A+ + +LT T +Y APEVL Sbjct: 132 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL 191 Query: 187 LQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPR 246 Y DMWS+G I + P F N GL + + + Sbjct: 192 GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------------GLAISPGMKTRIRMGQ 239 Query: 247 GAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 303 F P P S E+ E L+ +L P +R++ + H ++ + P+ Sbjct: 240 YEF----PNPEWS---EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 289 >1NY3-A nrPDB Length = 400 Score = 78.2 bits (191), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 77/297 (25%), Positives = 125/297 (42%), Gaps = 38/297 (12%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVR-VPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +G+G G V + + + ALK ++ P REV L R A + P+ Sbjct: 70 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR-----------REVELHWR--ASQCPH 116 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 +VR++DV R+ + +V E +D +L + + ++M+ + Sbjct: 117 IVRIVDVYENLYAGRKC-LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 175 Query: 130 FLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVL 186 +LH+ I HRD+KPEN+L TS +KL DFG A+ + +LT T +Y APEVL Sbjct: 176 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL 235 Query: 187 LQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPR 246 Y DMWS+G I + P F N GL + + + Sbjct: 236 GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------------GLAISPGMKTRIRMGQ 283 Query: 247 GAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 303 F P P S E+ E L+ +L P +R++ + H ++ + P+ Sbjct: 284 YEF----PNPEWS---EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 333 >2YCR-A nrPDB Length = 323 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 78/302 (25%), Positives = 127/302 (42%), Gaps = 51/302 (16%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSV---RVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 +G GA G V A + + VA+K + + G ++ E+ +L++L H Sbjct: 18 LGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEILKKLN---H 74 Query: 69 PNVVRLMDVCATSRTDREIKVTL-----VFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 P ++++ + D I + L +F+ V + R L T K Q Sbjct: 75 PCIIKIKNFFDAE--DYYIVLELMEGGELFDKVVGNKR----------LKEATCKLYFYQ 122 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTLWY 180 L + +LH N I+HRDLKPEN+L++S +K+ DFG ++I + + T Y Sbjct: 123 MLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTY 182 Query: 181 RAPEVLLQ---STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 APEVL+ + Y VD WS+G I C L G PP + Sbjct: 183 LAPEVLVSVGTAGYNRAVDCWSLGVIL--------FIC-------------LSGYPPFSE 221 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 VSL + + V E+ E L+ ++L +P R + AL+H +L Sbjct: 222 HRTQVSL-KDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 280 Query: 298 DE 299 ++ Sbjct: 281 ED 282 >4CQG-A nrPDB Length = 331 Score = 78.2 bits (191), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 81/301 (26%), Positives = 122/301 (40%), Gaps = 45/301 (14%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 YE IG G + V A +G VA+K + + G LP R + L++ Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIK---IMDKNALGSDLP----RVKTEIDALKS 63 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQF 124 H ++ +L V T K+ +V E+ +L Y+ L E + + RQ Sbjct: 64 LRHQHICQLYHVLETKN-----KIFMVLEYCPGGELFDYI--ISQDRLSEEETRVVFRQI 116 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR--IYSYQMALTPVVVTLWYRA 182 L + ++H+ HRDLKPEN+L +KL DFGL + L +L Y A Sbjct: 117 LSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAA 176 Query: 183 PEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 PE++ +Y + D+WS+G + L CG LP +DD Sbjct: 177 PELIQGKSYLGSEADVWSMGILLY------VLMCG--------------FLPFDDD---- 212 Query: 242 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGN 301 A + R V + S LL +ML +P KRIS L H ++ +D Sbjct: 213 ---NVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSC 269 Query: 302 P 302 P Sbjct: 270 P 270 >6C9D-A nrPDB Length = 459 Score = 77.8 bits (190), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 58/201 (28%), Positives = 91/201 (45%), Gaps = 15/201 (7%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y IG G + V AR +G VA+K + P S + +R ++ Sbjct: 23 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLN------PTSLQKLFREVRIMKI 76 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQF 124 HPN+V+L +V T +T + LV E+ ++ YL + + + RQ Sbjct: 77 LNHPNIVKLFEVIETEKT-----LYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQI 129 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 + + + H IVHRDLK EN+L+ +K+ADFG + ++ L + Y APE Sbjct: 130 VSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYAAPE 189 Query: 185 VLLQSTYATP-VDMWSVGCIF 204 + Y P VD+WS+G I Sbjct: 190 LFQGKKYDGPEVDVWSLGVIL 210 >3UIU-A nrPDB Length = 306 Score = 77.8 bits (190), Expect = 5e-15, Method: Compositional matrix adjust. Identities = 59/229 (25%), Positives = 95/229 (41%), Gaps = 39/229 (17%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 ++ + IG G +G V+KA+ G ++ V+ N REV L +L+ Sbjct: 14 FKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNNEKAE---------REVKALAKLD- 63 Query: 66 FEHPNVVRLMDVC----------------------ATSRTDREIKVTLVF---EHVDQ-D 99 H N+V + C S+ K +F E D+ Sbjct: 64 --HVNIVH-YNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGT 120 Query: 100 LRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADF 159 L +++K L +L Q +G+D++H+ ++HRDLKP NI + VK+ DF Sbjct: 121 LEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDF 180 Query: 160 GLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 GL T TL Y +PE + Y VD++++G I AE+ Sbjct: 181 GLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL 229 >2BUJ-A nrPDB Length = 317 Score = 77.8 bits (190), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 82/311 (26%), Positives = 125/311 (40%), Gaps = 55/311 (17%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 Y + ++G G + V H GHF ALK + + A + R Sbjct: 28 NKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDR------EEAQREADMHR 81 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPG--LPAETIKDL 120 L F HPN++RL+ C R + L+ L +++ G L + I L Sbjct: 82 L--FNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWL 139 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFG-----LARIYSYQMALT--- 172 + RGL+ +HA HRDLKP NIL+ G L D G + + ALT Sbjct: 140 LLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQD 199 Query: 173 --PVVVTLWYRAPEVLLQSTYAT---PVDMWSVGCI-FAEMFRRKPLFCGNSEADQLGKI 226 T+ YRAPE+ ++ D+WS+GC+ +A MF P D + + Sbjct: 200 WAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY-------DMVFQK 252 Query: 227 FDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKR--- 283 D + L ++ +S+P+ P + QLL M+T +PH+R Sbjct: 253 GDSVALAVQN----QLSIPQS--------------PRHSSALWQLLNSMMTVDPHQRPHI 294 Query: 284 ---ISAFRALQ 291 +S ALQ Sbjct: 295 PLLLSQLEALQ 305 >3VN9-A nrPDB Length = 340 Score = 77.4 bits (189), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 61/213 (28%), Positives = 100/213 (46%), Gaps = 28/213 (13%) Query: 7 EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF 66 EP+ E+G GAYG V K R SG +A+K +R +++ + LL L+ Sbjct: 54 EPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT----------VNSQEQKRLLMDLDI- 102 Query: 67 EHPNVVRLMDVCATSRTD-----REIKVTLVFEHVDQDLRTYLDKAPPPG--LPAETIKD 119 +R +D C + T RE V + E +D L + + G +P + + Sbjct: 103 ----SMRTVD-CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGK 157 Query: 120 LMRQFLRGLDFLHAN-CIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTL 178 + ++ L+ LH+ ++HRD+KP N+L+ + G VK+ DFG++ +A T Sbjct: 158 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCK 217 Query: 179 WYRAPE----VLLQSTYATPVDMWSVGCIFAEM 207 Y APE L Q Y+ D+WS+G E+ Sbjct: 218 PYMAPERINPELNQKGYSVKSDIWSLGITMIEL 250 >2PSQ-A nrPDB Length = 370 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 51/160 (31%), Positives = 80/160 (50%), Gaps = 23/160 (14%) Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGL---------PAE- 115 +H N++ L+ C ++ + ++ E+ + +LR YL PPG+ P E Sbjct: 145 KHKNIINLLGACT-----QDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQ 199 Query: 116 -TIKDLMR---QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS---YQ 168 T KDL+ Q RG+++L + +HRDL N+LVT +K+ADFGLAR + Y Sbjct: 200 MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYY 259 Query: 169 MALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 T + + + APE L Y D+WS G + E+F Sbjct: 260 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIF 299 >2HAK-A nrPDB Length = 328 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 58/201 (28%), Positives = 91/201 (45%), Gaps = 15/201 (7%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y IG G + V AR +G VA+K + P S + +R ++ Sbjct: 17 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLN------PTSLQKLFREVRIMKI 70 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQF 124 HPN+V+L +V T +T + LV E+ ++ YL + + + RQ Sbjct: 71 LNHPNIVKLFEVIETEKT-----LYLVMEYASGGEVFDYL--VAHGRMKEKEARAKFRQI 123 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 + + + H IVHRDLK EN+L+ +K+ADFG + ++ L + Y APE Sbjct: 124 VSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPE 183 Query: 185 VLLQSTYATP-VDMWSVGCIF 204 + Y P VD+WS+G I Sbjct: 184 LFQGKKYDGPEVDVWSLGVIL 204 >5DYK-A nrPDB Length = 853 Score = 77.0 bits (188), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 70/221 (31%), Positives = 102/221 (46%), Gaps = 18/221 (8%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA-FEHPN 70 IG G +GTV + ALK V + ++ + L R + A +HP Sbjct: 547 IGRGTFGTVKLVHHKPTKIRYALKCV------SKRSIINLNQQNNIKLEREITAENDHPF 600 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL-MRQFLRGLD 129 ++RL+ RT ++ K + Y D GL +++ + + ++ Sbjct: 601 IIRLV------RTFKDSKYFYFLTELVTGGELY-DAIRKLGLLSKSQAQFYLGSIILAIE 653 Query: 130 FLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQS 189 +LH IV+RDLKPENIL+ G VKL DFG A+ Q +V T Y APEV+L Sbjct: 654 YLHERNIVYRDLKPENILLDKQGYVKLIDFGCAK--KVQGRAYTLVGTPHYMAPEVILGK 711 Query: 190 TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLI 230 Y VD+W++G E F PL GN E DQL D++ Sbjct: 712 GYGCTVDIWALGICLYE-FICGPLPFGNDEEDQLEIFRDIL 751 >3IS5-A nrPDB Length = 285 Score = 77.0 bits (188), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 69/293 (23%), Positives = 120/293 (40%), Gaps = 43/293 (14%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 ++G GA+G V+ + SG +K++ +P+ + A + L++ +HPN Sbjct: 29 KLGSGAFGDVHLVEERSSGLERVIKTI-----NKDRSQVPMEQIE--AEIEVLKSLDHPN 81 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDL---RTYLDKAPPPGLPAETIKDLMRQFLRG 127 ++++ +V + +V E + R +A L + +LM+Q + Sbjct: 82 IIKIFEVFEDYHN-----MYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNA 136 Query: 128 LDFLHANCIVHRDLKPENIL---VTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 L + H+ +VH+DLKPENIL + +K+ DFGLA ++ T T Y APE Sbjct: 137 LAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPE 196 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244 V + D+WS G + + F G S +V Sbjct: 197 VFKRDV-TFKCDIWSAGVVMYFLLTGCLPFTGTS--------------------LEEVQQ 235 Query: 245 PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 P + + P+ LL +MLT +P +R SA + L H + + Sbjct: 236 KATYKEPNYAVECRPLTPQ----AVDLLKQMLTKDPERRPSAAQVLHHEWFKQ 284 >3LM0-A nrPDB Length = 327 Score = 77.0 bits (188), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 54/181 (29%), Positives = 82/181 (45%), Gaps = 26/181 (14%) Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSG---GTVKLADFGLARIYSYQMALTPVVV 176 L++Q L G+ +LH N IVH DLKP+NIL++S G +K+ DFG++R + L ++ Sbjct: 136 LIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMG 195 Query: 177 TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPED 236 T Y APE+L T DMW++G I + F G + I + Sbjct: 196 TPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQV------- 248 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 +V F S V ++ + +L NP KR +A L HS+L Sbjct: 249 ----NVDYSEETF---------SSVSQL---ATDFIQSLLVKNPEKRPTAEICLSHSWLQ 292 Query: 297 K 297 + Sbjct: 293 Q 293 >5F9E-A nrPDB Length = 353 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 63/228 (27%), Positives = 101/228 (44%), Gaps = 13/228 (5%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + +E +G G++G V+ A + F A+K+++ + + + V + L Sbjct: 16 LKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALK-KDVVLMDDDVECTMVEKRVLS 74 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKD 119 A+EHP + + T + V E+++ DL ++ L T Sbjct: 75 L---AWEHPFLTHMFCTFQTKEN-----LFFVMEYLNGGDLMYHIQSCHKFDLSRATF-- 124 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TL 178 + + GL FLH+ IV+RDLK +NIL+ G +K+ADFG+ + A T T Sbjct: 125 YAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTP 184 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI 226 Y APE+LL Y VD WS G + EM + F G E + I Sbjct: 185 DYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSI 232 >4FR4-A nrPDB Length = 384 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 62/222 (27%), Positives = 104/222 (46%), Gaps = 17/222 (7%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREV-ALLRRLE 64 +E + IG G++G V + + A+K + + + VR V L+ ++ Sbjct: 17 FEILRAIGKGSFGKVCIVQKNDTKKMYAMKYM------NKQKCVERNEVRNVFKELQIMQ 70 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 EHP +V L S D E +V + DLR +L + ET+K + + Sbjct: 71 GLEHPFLVNLW----YSFQDEEDMFMVVDLLLGGDLRYHLQQNV--HFKEETVKLFICEL 124 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 + LD+L I+HRD+KP+NIL+ G V + DF +A + + +T + T Y APE Sbjct: 125 VMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPE 184 Query: 185 VLLQ---STYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQ 222 + + Y+ VD WS+G E+ R R+P +S + + Sbjct: 185 MFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSK 226 >5O2C-A nrPDB Length = 380 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 62/203 (30%), Positives = 98/203 (48%), Gaps = 19/203 (9%) Query: 11 EIGVGAYGTVYKARDPHSGHFVA---LKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 E+G GA+ TVYK D + VA L+ ++ +E A + L+ + Sbjct: 32 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ-------QRFKEEAEM--LKGLQ 82 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 HPN+VR D + ++ V + L+TYL + + + ++ RQ L+G Sbjct: 83 HPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKV--MKPKVLRSWCRQILKG 140 Query: 128 LDFLHANC--IVHRDLKPENILVTS-GGTVKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 L FLH I+HRDLK +NI +T G+VK+ D GLA + A + V+ T + APE Sbjct: 141 LQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKS-VIGTPEFMAPE 199 Query: 185 VLLQSTYATPVDMWSVGCIFAEM 207 + + Y VD+++ G EM Sbjct: 200 -MYEEHYDESVDVYAFGMCMLEM 221 >3I6U-A nrPDB Length = 419 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 77/302 (25%), Positives = 127/302 (42%), Gaps = 51/302 (16%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSV---RVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 +G GA G V A + + VA++ + + G ++ E+ +L++L H Sbjct: 143 LGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEILKKLN---H 199 Query: 69 PNVVRLMDVCATSRTDREIKVTL-----VFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 P ++++ + D I + L +F+ V + R L T K Q Sbjct: 200 PCIIKIKNFFDAE--DYYIVLELMEGGELFDKVVGNKR----------LKEATCKLYFYQ 247 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTLWY 180 L + +LH N I+HRDLKPEN+L++S +K+ DFG ++I + + T Y Sbjct: 248 MLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTY 307 Query: 181 RAPEVLLQ---STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 APEVL+ + Y VD WS+G I C L G PP + Sbjct: 308 LAPEVLVSVGTAGYNRAVDCWSLGVIL--------FIC-------------LSGYPPFSE 346 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 VSL + + V E+ E L+ ++L +P R + AL+H +L Sbjct: 347 HRTQVSL-KDQITSGKYNFIPEVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 405 Query: 298 DE 299 ++ Sbjct: 406 ED 407 >5O2B-A nrPDB Length = 285 Score = 77.0 bits (188), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 62/203 (30%), Positives = 97/203 (47%), Gaps = 19/203 (9%) Query: 11 EIGVGAYGTVYKARDPHSGHFVA---LKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 E+G GA+ TVYK D + VA L+ ++ +E A + L+ + Sbjct: 23 ELGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ-------QRFKEEAEM--LKGLQ 73 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 HPN+VR D + ++ V + L+TYL + + + ++ RQ L+G Sbjct: 74 HPNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKV--MKPKVLRSWCRQILKG 131 Query: 128 LDFLHANC--IVHRDLKPENILVTS-GGTVKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 L FLH I+HRDLK +NI +T G+VK+ D GLA + A V+ T + APE Sbjct: 132 LQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFA-KSVIGTPEFMAPE 190 Query: 185 VLLQSTYATPVDMWSVGCIFAEM 207 + + Y VD+++ G EM Sbjct: 191 -MYEEHYDESVDVYAFGMCMLEM 212 >3ORP-A nrPDB Length = 311 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 63/220 (28%), Positives = 101/220 (45%), Gaps = 11/220 (5%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + RYE +G G V+ ARD VA+K +R P +R + Sbjct: 11 SDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARD-----PSFYLRFRREAQN 65 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 A HP +V + D + T +V E+VD + P P I +++ Sbjct: 66 AAALNHPAIVAVYD-TGEAETPAGPLPYIVMEYVDGVTLRDIVHTEGPMTPKRAI-EVIA 123 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYSYQMALT---PVVVTL 178 + L+F H N I+HRD+KP NI++++ VK+ DFG+AR I ++T V+ T Sbjct: 124 DACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGTA 183 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNS 218 Y +PE + D++S+GC+ E+ +P F G+S Sbjct: 184 QYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDS 223 >4GS6-A nrPDB Length = 315 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 69/211 (32%), Positives = 98/211 (46%), Gaps = 32/211 (15%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G GA+G V KA+ VA+K + + + LR+L HPN+ Sbjct: 17 VGRGAFGVVCKAK--WRAKDVAIKQIESES----------ERKAFIVELRQLSRVNHPNI 64 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMR---QFLRG 127 V+L C V LV E+ + L L A P LP T M Q +G Sbjct: 65 VKLYGACLNP-------VCLVMEYAEGGSLYNVLHGAEP--LPYYTAAHAMSWCLQCSQG 115 Query: 128 LDFLHA---NCIVHRDLKPENILVTSGGTV-KLADFGLARIYSYQMALTPVVVTLWYRAP 183 + +LH+ ++HRDLKP N+L+ +GGTV K+ DFG A Q +T + + AP Sbjct: 116 VAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAWMAP 173 Query: 184 EVLLQSTYATPVDMWSVGCIFAEMF-RRKPL 213 EV S Y+ D++S G I E+ RRKP Sbjct: 174 EVFEGSNYSEKCDVFSWGIILWEVITRRKPF 204 >3FXW-A nrPDB Length = 336 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 62/232 (26%), Positives = 103/232 (44%), Gaps = 23/232 (9%) Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 P++V ++DV + + ++ +L + + + ++MR + Sbjct: 82 PHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAI 141 Query: 129 DFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 FLH++ I HRD+KPEN+L TS +KL DFG A+ + Q AL T +Y APEV Sbjct: 142 QFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAK-ETTQNALQTPCYTPYYVAPEV 200 Query: 186 LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP 245 L Y DMWS+G I + P F N+ G R + L Sbjct: 201 LGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNT------------GQAISPGMKRRIRLG 248 Query: 246 RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 + F P P S E+ E QL+ +L +P +R++ + + H ++++ Sbjct: 249 QYGF----PNPEWS---EVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQ 293 >3GQL-A nrPDB Length = 326 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 63/220 (28%), Positives = 102/220 (46%), Gaps = 32/220 (14%) Query: 12 IGVGAYGTVYKAR----DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 +G GA+G V A D + V +V++ L + E+ +++ + + Sbjct: 36 LGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLS-DLISEMEMMKMIG--K 92 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGL---------PAETI 117 H N++ L+ C ++ + ++ E+ + +LR YL PPGL P E + Sbjct: 93 HKNIINLLGACT-----QDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQL 147 Query: 118 --KDLMR---QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR----IYSYQ 168 KDL+ Q RG+++L + +HRDL N+LVT +K+ADFGLAR I Y+ Sbjct: 148 SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYK 207 Query: 169 MALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 + W APE L Y D+WS G + E+F Sbjct: 208 KTTNGRLPVKWM-APEALFDRIYTHQSDVWSFGVLLWEIF 246 >5TQX-A nrPDB Length = 655 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 66/212 (31%), Positives = 92/212 (43%), Gaps = 24/212 (11%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPIST------VREVAL 59 +E +G G +G V + +A+KS R L +ST E+ + Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCR----------LELSTKNRERWCHEIQI 59 Query: 60 LRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDK-APPPGLPAETI 117 +++L H NVV+ DV L E+ DLR L+K GL I Sbjct: 60 MKKLN---HANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQI 116 Query: 118 KDLMRQFLRGLDFLHANCIVHRDLKPENILVTS-GGTV--KLADFGLARIYSYQMALTPV 174 L+ G+ +LH N I+HRDLKPENI++ GG + K+ D G A+ T Sbjct: 117 LSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEF 176 Query: 175 VVTLWYRAPEVLLQSTYATPVDMWSVGCIFAE 206 V TL Y APE+ Y VD WS G + E Sbjct: 177 VGTLQYLAPELFENKPYTATVDYWSFGTMVFE 208 >5A46-A nrPDB Length = 386 Score = 76.3 bits (186), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 52/161 (32%), Positives = 79/161 (49%), Gaps = 25/161 (15%) Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGL---------PAET 116 +H N++ L+ C ++ + ++ E+ + +LR YL PPGL P E Sbjct: 104 KHKNIINLLGACT-----QDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQ 158 Query: 117 I--KDLMR---QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR----IYSY 167 + KDL+ Q RG+++L + +HRDL N+LVT +K+ADFGLAR I Y Sbjct: 159 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 218 Query: 168 QMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 + + W APE L Y D+WS G + E+F Sbjct: 219 KKTTNGRLPVKWM-APEALFDRIYTHQSDVWSFGVLLWEIF 258 >4D28-A nrPDB Length = 446 Score = 76.3 bits (186), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 60/203 (29%), Positives = 96/203 (47%), Gaps = 15/203 (7%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 +YE IG G + V AR+ +G VA+K + + RE+++++ Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIM--AKSTILKNRMVDQIKREISIMK--- 64 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPG-LPAETIKDLMRQ 123 HPN+VRL +V A+ K+ +V E V D+ G L + + +Q Sbjct: 65 IVRHPNIVRLYEVLASKS-----KIYIVLEFVTGG--ELFDRIVHKGRLKEDESRKYFQQ 117 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-LTPVVVTLWYRA 182 + + H+ + HRDLKPEN+L+ + G +K++DFGL+ + + L T Y A Sbjct: 118 LVDAVAHCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYVA 177 Query: 183 PEVLLQSTY-ATPVDMWSVGCIF 204 PEVL Y + D+WS G I Sbjct: 178 PEVLSGQGYDGSAADIWSCGVIL 200 >3TT0-A nrPDB Length = 382 Score = 76.3 bits (186), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 63/220 (28%), Positives = 102/220 (46%), Gaps = 32/220 (14%) Query: 12 IGVGAYGTVYKAR----DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 +G GA+G V A D + V +V++ L + E+ +++ + + Sbjct: 77 LGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLS-DLISEMEMMKMIG--K 133 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGL---------PAETI 117 H N++ L+ C ++ + ++ E+ + +LR YL PPGL P E + Sbjct: 134 HKNIINLLGACT-----QDGPLYVIVEYASKGNLREYLQARRPPGLEYSYNPSHNPEEQL 188 Query: 118 --KDLMR---QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR----IYSYQ 168 KDL+ Q RG+++L + +HRDL N+LVT +K+ADFGLAR I Y+ Sbjct: 189 SSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYK 248 Query: 169 MALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 + W APE L Y D+WS G + E+F Sbjct: 249 KTTNGRLPVKWM-APEALFDRIYTHQSDVWSFGVLLWEIF 287 >6CTH-A nrPDB Length = 309 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 58/211 (27%), Positives = 101/211 (47%), Gaps = 20/211 (9%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 TS + ++G G +G+VY+ S ++A+K V + G EV ++ R Sbjct: 14 TSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQG-----IKEYASEVKIISR 68 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLM 121 L H N+V+L+ C ++ LV+E + + L +++ K L E ++ Sbjct: 69 LR---HKNLVKLIGWC-----HERGELMLVYEFMANGSLDSHIFKGKSL-LTWEVRYRIV 119 Query: 122 RQFLRGLDFLHA---NCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-- 176 + L +LH +C++HRD+K NI++ S KL DFGLAR+ + L ++ Sbjct: 120 KDLASALLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLAG 179 Query: 177 TLWYRAPEVLLQSTYATPVDMWSVGCIFAEM 207 T+ Y APE L + D++S G + E+ Sbjct: 180 TVGYMAPECLSSGKASKESDVYSFGVVALEI 210 >2W1I-A nrPDB Length = 326 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 62/211 (29%), Positives = 103/211 (48%), Gaps = 25/211 (11%) Query: 9 VAEIGVGAYGTVYKAR-DP---HSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 + ++G G +G+V R DP ++G VA+K ++ RE+ +L+ L+ Sbjct: 46 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEH-----LRDFEREIEILKSLQ 100 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLM-- 121 H N+V+ VC ++ R +K L+ E++ LR YL K + IK L Sbjct: 101 ---HDNIVKYKGVCYSA-GRRNLK--LIMEYLPYGSLRDYLQKHKER---IDHIKLLQYT 151 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALTPVVVT 177 Q +G+++L +HRDL NILV + VK+ DFGL ++ Y P Sbjct: 152 SQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESP 211 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 +++ APE L +S ++ D+WS G + E+F Sbjct: 212 IFWYAPESLTESKFSVASDVWSFGVVLYELF 242 >3IO7-A nrPDB Length = 313 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 63/215 (29%), Positives = 102/215 (47%), Gaps = 33/215 (15%) Query: 9 VAEIGVGAYGTVYKAR-DP---HSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR-- 62 + ++G G +G+V R DP ++G VA+K L ST + R Sbjct: 33 LQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKK------------LQHSTEEHLRDFEREI 80 Query: 63 --LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKD 119 L++ +H N+V+ VC ++ R +K L+ E++ LR YL K + IK Sbjct: 81 EILKSLQHDNIVKYKGVCYSA-GRRNLK--LIMEYLPYGSLRDYLQKHKER---IDHIKL 134 Query: 120 LM--RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALTP 173 L Q +G+++L +HRDL NILV + VK+ DFGL ++ Y P Sbjct: 135 LQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEP 194 Query: 174 VVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 +++ APE L +S ++ D+WS G + E+F Sbjct: 195 GESPIFWYAPESLTESKFSVASDVWSFGVVLYELF 229 >4D2V-A nrPDB Length = 356 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 80/301 (26%), Positives = 121/301 (40%), Gaps = 45/301 (14%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 YE IG G + V A +G VA+K + + G LP R + L+ Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIK---IMDKNTLGSDLP----RIKTEIEALKN 83 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQF 124 H ++ +L V T+ K+ +V E+ +L Y+ L E + + RQ Sbjct: 84 LRHQHICQLYHVLETAN-----KIFMVLEYCPGGELFDYI--ISQDRLSEEETRVVFRQI 136 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR--IYSYQMALTPVVVTLWYRA 182 + + ++H+ HRDLKPEN+L +KL DFGL + L L Y A Sbjct: 137 VSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAA 196 Query: 183 PEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 PE++ +Y + D+WS+G + L CG LP +DD Sbjct: 197 PELIQGKSYLGSEADVWSMGILLY------VLMCG--------------FLPFDDD---- 232 Query: 242 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGN 301 A + R V + S LL +ML +P KRIS L H ++ +D Sbjct: 233 ---TAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNY 289 Query: 302 P 302 P Sbjct: 290 P 290 >5EG3-A nrPDB Length = 334 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 64/221 (28%), Positives = 100/221 (45%), Gaps = 34/221 (15%) Query: 12 IGVGAYGTVYKAR-------DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 +G GA+G V A P VA+K ++ L V E+ +++ + Sbjct: 43 LGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDL----VSEMEMMKMIG 98 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGL---------PAE 115 +H N++ L+ C D + V + + +LR YL PPG+ P E Sbjct: 99 --KHKNIINLLGACTQ---DGPLYVIVAYAS-KGNLREYLRARRPPGMELSPDINRVPEE 152 Query: 116 --TIKDLMR---QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS---Y 167 T KDL+ Q RG+++L + +HRDL N+LVT +K+ADFGLAR + + Sbjct: 153 QMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDF 212 Query: 168 QMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 T + + + APE L Y D+WS G + E+F Sbjct: 213 FKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIF 253 >3ZZW-A nrPDB Length = 289 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 76/275 (27%), Positives = 123/275 (44%), Gaps = 44/275 (16%) Query: 11 EIGVGAYGTVYKAR--DPHSG---HFVALKSVRVPNGGGGGGGLPI-STVREVALLRRLE 64 E+G +G VYK P G VA+K+++ G P+ R A+LR Sbjct: 16 ELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEG------PLREEFRHEAMLR--A 67 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYL--------------DKAPP 109 +HPNVV L+ V ++ ++++F + DL +L D+ Sbjct: 68 RLQHPNVVCLLGVVT-----KDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVK 122 Query: 110 PGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYS-- 166 L L+ Q G+++L ++ +VH+DL N+LV VK++D GL R +Y+ Sbjct: 123 SALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAAD 182 Query: 167 YQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRR--KPLFCGNSEADQLG 224 Y L ++ + + APE ++ ++ D+WS G + E+F +P +CG S D + Sbjct: 183 YYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQP-YCGYSNQDVVE 241 Query: 225 KIFDLIGLPPEDDWPRDVSL----PRGAFPPRGPR 255 I + LP DD P V FP R PR Sbjct: 242 MIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPR 276 >6HV0-A nrPDB Length = 416 Score = 75.5 bits (184), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 77/256 (30%), Positives = 116/256 (45%), Gaps = 49/256 (19%) Query: 55 REVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPA 114 REV LLR E+ EHPNV+R + DR+ + + E L+ Y+++ L Sbjct: 50 REVQLLR--ESDEHPNVIRYF----CTEKDRQFQY-IAIELCAATLQEYVEQKDFAHLGL 102 Query: 115 ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT---SGGTVK--LADFGLARI----- 164 E I L++Q GL LH+ IVHRDLKP NIL++ + G +K ++DFGL + Sbjct: 103 EPIT-LLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGR 161 Query: 165 YSYQMALTPVVVTLWYRAPEVLLQSTYATP---VDMWSVGCIFAEMFRRKPLFCGNSEAD 221 +S+ + V T + APE+L + P VD++S GC+F + Sbjct: 162 HSFSRR-SGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVI------------- 207 Query: 222 QLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEES--GAQLLLEMLTFN 279 E P SL R A G + + PE E +L+ +M+ + Sbjct: 208 ------------SEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMD 255 Query: 280 PHKRISAFRALQHSYL 295 P KR SA L+H + Sbjct: 256 PQKRPSAKHVLKHPFF 271 >4B6L-A nrPDB Length = 281 Score = 75.5 bits (184), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 75/287 (26%), Positives = 118/287 (41%), Gaps = 39/287 (13%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G G + Y+A D +G A+K + P + E+ L R L+ H ++ Sbjct: 17 LGKGGFARCYEATDTETGSAYAVKVI--PQSRVAKPHQREKILNEIELHRDLQ---HRHI 71 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFL 131 VR + + + + E + ++ KA L E ++ +RQ L GL +L Sbjct: 72 VRF-----SHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPE-VRYYLRQILSGLKYL 125 Query: 132 HANCIVHRDLKPENILVTSGGTVKLADFGL-ARIYSYQMALTPVVVTLWYRAPEVLLQST 190 H I+HRDLK N +T +K+ DFGL AR+ + + T Y APEVLL+ Sbjct: 126 HQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQG 185 Query: 191 YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFP 250 + D+WS+GC+ + P F E L + + I P +SLP Sbjct: 186 HGPEADVWSLGCVMYTLLCGSPPF----ETADLKETYRCIK-QVHYTLPASLSLP----- 235 Query: 251 PRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 QLL +L +P R S + L+H + K Sbjct: 236 -----------------ARQLLAAILRASPRDRPSIDQILRHDFFTK 265 >3ORZ-A nrPDB Length = 316 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 67/233 (28%), Positives = 109/233 (46%), Gaps = 16/233 (6%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G G++ TV AR+ + A+K + +P T RE ++ RL+ HP Sbjct: 45 LGEGSFSTVVLARELATSREYAIKILE-KRHIIKENKVPYVT-RERDVMSRLD---HPFF 99 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR-QFLRGLDF 130 V+L C + D ++ L + + +L Y+ K G ET + + L++ Sbjct: 100 VKLY-FCF--QDDEKLYFGLSYAK-NGELLKYIRKI---GSFDETCTRFYTAEIVSALEY 152 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIY---SYQMALTPVVVTLWYRAPEVLL 187 LH I+HRDLKPENIL+ +++ DFG A++ S Q V T Y +PE+L Sbjct: 153 LHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLT 212 Query: 188 QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 + + D+W++GCI ++ P F +E KI L PE +P+ Sbjct: 213 EKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPK 265 >4UY9-A nrPDB Length = 323 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 65/210 (30%), Positives = 95/210 (45%), Gaps = 29/210 (13%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 IG+G +G VY+A G VA+K+ R + I VR+ A L +HPN+ Sbjct: 17 IGIGGFGKVYRAF--WIGDEVAVKAAR--HDPDEDISQTIENVRQEAKL--FAMLKHPNI 70 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQD--LRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 + L VC +E + LV E R K PP + + + Q RG++ Sbjct: 71 IALRGVCL-----KEPNLCLVMEFARGGPLNRVLSGKRIPP----DILVNWAVQIARGMN 121 Query: 130 FLHANCIV---HRDLKPENILVT--------SGGTVKLADFGLARIYSYQMALTPVVVTL 178 +LH IV HRDLK NIL+ S +K+ DFGLAR + ++ Sbjct: 122 YLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYA 181 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 W APEV+ S ++ D+WS G + E+ Sbjct: 182 WM-APEVIRASMFSKGSDVWSYGVLLWELL 210 >3UDB-A nrPDB Length = 317 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 65/214 (30%), Positives = 94/214 (43%), Gaps = 28/214 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + RYE V +IG G +G RD + VA+K + G + + RE+ R Sbjct: 18 SDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIE------RGEKIDENVKREIINHRS 71 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTL-----VFEHVDQDLRTYLDKAPPPGLPAETI 117 L HPN+VR +V T T I + +FE + R D+A Sbjct: 72 LR---HPNIVRFKEVILTP-THLAIVMEYASGGELFERICNAGRFSEDEA---------- 117 Query: 118 KDLMRQFLRGLDFLHANCIVHRDLKPENILV--TSGGTVKLADFGLARIYSYQMALTPVV 175 + +Q + G+ + HA + HRDLK EN L+ + +K+ADFG ++ V Sbjct: 118 RFFFQQLISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAV 177 Query: 176 VTLWYRAPEVLLQSTYATPV-DMWSVGCIFAEMF 208 T Y APEVLL+ Y V D+WS G M Sbjct: 178 GTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVML 211 >5VO2-A nrPDB Length = 300 Score = 75.1 bits (183), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 54/197 (27%), Positives = 90/197 (45%), Gaps = 23/197 (11%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G GA G V+ R G VA+K VR ++E + + L +HPN+ Sbjct: 20 VGSGAQGAVFLGR--FHGEEVAVKKVR--------------DLKETDI-KHLRKLKHPNI 62 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFL 131 + VC + ++ E Q + +A P P+ + D G+++L Sbjct: 63 ITFKGVCTQAPC-----YCILMEFCAQGQLYEVLRAGRPVTPSLLV-DWSMGIAGGMNYL 116 Query: 132 HANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTY 191 H + I+HRDLK N+L+T VK++DFG ++ S + T+ + APEV+ Sbjct: 117 HLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPV 176 Query: 192 ATPVDMWSVGCIFAEMF 208 + VD+WS G + E+ Sbjct: 177 SEKVDIWSFGVVLWELL 193 >5FET-A nrPDB Length = 847 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 72/231 (31%), Positives = 103/231 (44%), Gaps = 38/231 (16%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA-FEHPN 70 IG G +GTV + ALK V + ++ + L R + A +HP Sbjct: 541 IGRGTFGTVKLVHHKPTQIRYALKCV------SKRSIISLNQQNNIKLEREITAENDHPF 594 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL------MRQF 124 ++RL+ RT + D + +L + G + I+ L QF Sbjct: 595 IIRLV------RTFK-----------DSNCFYFLTELVTGGELYDAIRKLGLLSKPQAQF 637 Query: 125 LRG-----LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLW 179 G +++LH IV+RDLKPENIL+ G VKL DFG A+ Q +V T Sbjct: 638 YLGSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAK--KIQGRAYTLVGTPH 695 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLI 230 Y APEV+L Y VD+W++G E F PL GN + DQL D++ Sbjct: 696 YMAPEVILGKGYGCTVDIWALGVCLYE-FICGPLPFGNDQEDQLEIFRDIL 745 >4NIF-A nrPDB Length = 333 Score = 74.7 bits (182), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 85/308 (27%), Positives = 130/308 (42%), Gaps = 64/308 (20%) Query: 12 IGVGAYG----TVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 IGVG+Y V+KA + V KS R P+ E+ +L R + Sbjct: 16 IGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPS-------------EEIEILLRYG--Q 60 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEH------VDQDLRTYLDKAPPPGLPAETIKDLM 121 HPN++ L DV D V LV E +D+ LR TI Sbjct: 61 HPNIITLKDV-----YDDGKHVYLVTELMRGGELLDKILRQKFFSEREASFVLHTIG--- 112 Query: 122 RQFLRGLDFLHANCIVHRDLKPENIL-VTSGGT---VKLADFGLARIYSYQ--MALTPVV 175 + +++LH+ +VHRDLKP NIL V G +++ DFG A+ + + +TP Sbjct: 113 ----KTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTP-C 167 Query: 176 VTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPE 235 T + APEVL + Y D+WS+G + M F N +D +I IG Sbjct: 168 YTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIG---- 222 Query: 236 DDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 G F G + E+ L+ +ML +PH+R++A + LQH ++ Sbjct: 223 ----------SGKFTLSGGN-----WNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWV 267 Query: 296 HKDEGNPE 303 + + P+ Sbjct: 268 TQKDKLPQ 275 >3DTC-A nrPDB Length = 271 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 67/218 (30%), Positives = 98/218 (44%), Gaps = 29/218 (13%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 IG+G +G VY+A G VA+K+ R + I VR+ A L +HPN+ Sbjct: 15 IGIGGFGKVYRAF--WIGDEVAVKAAR--HDPDEDISQTIENVRQEAKL--FAMLKHPNI 68 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQD--LRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 + L VC +E + LV E R K PP + + + Q RG++ Sbjct: 69 IALRGVCL-----KEPNLCLVMEFARGGPLNRVLSGKRIPP----DILVNWAVQIARGMN 119 Query: 130 FLHANCIV---HRDLKPENILVT--------SGGTVKLADFGLARIYSYQMALTPVVVTL 178 +LH IV HRDLK NIL+ S +K+ DFGLAR + ++ Sbjct: 120 YLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYA 179 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCG 216 W APEV+ S ++ D+WS G + E+ + F G Sbjct: 180 WM-APEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRG 216 >5D9K-A nrPDB Length = 330 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 64/233 (27%), Positives = 105/233 (45%), Gaps = 13/233 (5%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 S++E + +G G++G V+ + L +++V + T E +L + Sbjct: 30 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEV 89 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMR 122 HP +V+L T E K+ L+ + + DL T L K E +K + Sbjct: 90 N---HPFIVKLHYAFQT-----EGKLYLILDFLRGGDLFTRLSKEVM--FTEEDVKFYLA 139 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYSYQMALTPVVVTLWYR 181 + LD LH+ I++RDLKPENIL+ G +KL DFGL++ ++ T+ Y Sbjct: 140 ELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYM 199 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDL-IGLP 233 APEV+ + + D WS G + EM F G + + I +G+P Sbjct: 200 APEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMP 252 >3QGY-A nrPDB Length = 286 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 55/207 (26%), Positives = 93/207 (44%), Gaps = 27/207 (13%) Query: 9 VAEIGVGAYGTVYKARDPHSGHF-----VALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 V EIG G +G V H G++ VA+K+++ G + E ++ +L Sbjct: 32 VQEIGSGQFGLV------HLGYWLNKDKVAIKTIK------EGSMSEDDFIEEAEVMMKL 79 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 HP +V+L VC + + LVFE ++ + + AET+ + Sbjct: 80 S---HPKLVQLYGVCL-----EQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLD 131 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY--SYQMALTPVVVTLWYR 181 G+ +L C++HRDL N LV +K++DFG+ R + T + + Sbjct: 132 VCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWA 191 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEMF 208 +PEV S Y++ D+WS G + E+F Sbjct: 192 SPEVFSFSRYSSKSDVWSFGVLMWEVF 218 >3FME-A nrPDB Length = 290 Score = 74.3 bits (181), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 60/213 (28%), Positives = 99/213 (46%), Gaps = 28/213 (13%) Query: 7 EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF 66 EP+ E+G GAYG V K R SG +A+K +R +++ + LL L+ Sbjct: 10 EPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT----------VNSQEQKRLLMDLDI- 58 Query: 67 EHPNVVRLMDVCATSRTD-----REIKVTLVFEHVDQDLRTYLDKAPPPG--LPAETIKD 119 +R +D C + T RE V + E +D L + + G +P + + Sbjct: 59 ----SMRTVD-CPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGK 113 Query: 120 LMRQFLRGLDFLHAN-CIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTL 178 + ++ L+ LH+ ++HRD+KP N+L+ + G VK+ DFG++ +A Sbjct: 114 IAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGCK 173 Query: 179 WYRAPE----VLLQSTYATPVDMWSVGCIFAEM 207 Y APE L Q Y+ D+WS+G E+ Sbjct: 174 PYMAPERINPELNQKGYSVKSDIWSLGITMIEL 206 >4XBR-A nrPDB Length = 366 Score = 74.3 bits (181), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 75/288 (26%), Positives = 127/288 (44%), Gaps = 40/288 (13%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +IG G+ G V A SG VA+K + + EV ++R ++H N Sbjct: 101 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRE-----LLFNEVVIMR---DYQHEN 152 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 VV + + ++ +V E ++ T D + E I + L+ L Sbjct: 153 VVEMYNSYLVGD-----ELWVVMEFLEGGALT--DIVTHTRMNEEQIAAVCLAVLQALSV 205 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLWYRAPEVLLQS 189 LHA ++HRD+K ++IL+T G VKL+DFG S ++ +V T ++ APE++ + Sbjct: 206 LHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL 265 Query: 190 TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAF 249 Y VD+WS+G + EM +P + PP + + + R Sbjct: 266 PYGPEVDIWSLGIMVIEMVDGEPPYFNE---------------PP----LKAMKMIRDNL 306 Query: 250 PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 PPR + + V P ++ L +L +P +R +A L+H +L K Sbjct: 307 PPR-LKNLHKVSPSLK----GFLDRLLVRDPAQRATAAELLKHPFLAK 349 >5HI2-A nrPDB Length = 283 Score = 73.9 bits (180), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 67/250 (26%), Positives = 113/250 (45%), Gaps = 32/250 (12%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 IG G++GTVYK + H VA+K + P + EV +LR+ H N+ Sbjct: 28 IGSGSFGTVYKGK-WHGD--VAVKML-TPQQ-------LQAFKNEVGVLRKTR---HVNI 73 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFL 131 + M ++ +V + + + A + + D+ RQ RG+D+L Sbjct: 74 LLFMGYSTKP------QLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYL 127 Query: 132 HANCIVHRDLKPENILVTSGGTVKLADFGLARI---YSYQMALTPVVVTLWYRAPEVL-L 187 HA I+HRDLK NI + TVK+ DFGLA + +S + ++ + APEV+ + Sbjct: 128 HAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRM 187 Query: 188 QST--YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP 245 Q + Y+ D+++ G + E+ + + + DQ+ ++ L P D+S Sbjct: 188 QDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSP------DLSKV 241 Query: 246 RGAFPPRGPR 255 R P R R Sbjct: 242 RSNCPKRMKR 251 >4K33-A nrPDB Length = 325 Score = 73.9 bits (180), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 53/159 (33%), Positives = 74/159 (46%), Gaps = 21/159 (13%) Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGL---------PAE-- 115 +H N++ L+ C T LV +LR +L PPGL P E Sbjct: 100 KHKNIINLLGAC----TQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTSKPPEEQL 155 Query: 116 TIKDLMR---QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR---IYSYQM 169 T KDL+ Q RG+++L + +HRDL N+LVT +K+ADFGLAR Y Sbjct: 156 TFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYK 215 Query: 170 ALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 T + + + APE L Y D+WS G + E+F Sbjct: 216 ETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIF 254 >4XLV-A nrPDB Length = 328 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 68/221 (30%), Positives = 101/221 (45%), Gaps = 43/221 (19%) Query: 11 EIGVGAYGTVYK--ARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR------ 62 E+G G++G VY+ ARD G RV + TV E A LR Sbjct: 46 ELGQGSFGMVYEGNARDIIKGE----AETRVA----------VKTVNESASLRERIEFLN 91 Query: 63 ----LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPP-----PGLP 113 ++ F +VVRL+ V S+ + V + H DL++YL P PG P Sbjct: 92 EASVMKGFTCHHVVRLLGV--VSKGQPTLVVMELMAH--GDLKSYLRSLRPEAENNPGRP 147 Query: 114 AETIKDLMR---QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYS--- 166 T++++++ + G+ +L+A VHRDL N +V TVK+ DFG+ R IY Sbjct: 148 PPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDY 207 Query: 167 YQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEM 207 Y+ ++ W APE L + T DMWS G + E+ Sbjct: 208 YRKGGKGLLPVRWM-APESLKDGVFTTSSDMWSFGVVLWEI 247 >4XCU-A nrPDB Length = 300 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 61/214 (28%), Positives = 94/214 (43%), Gaps = 29/214 (13%) Query: 12 IGVGAYGTVYKARD-------PHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 +G G +G V +A P VA+K ++ N +S + + L+ R Sbjct: 25 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLK-DNASDKDLADLVSEMEVMKLIGR-- 81 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPG-----LPAETIK 118 H N++ L+ VC +E + ++ E + +LR +L PPG L + Sbjct: 82 ---HKNIINLLGVCT-----QEGPLYVIVECAAKGNLREFLRARRPPGSSEGPLSFPVLV 133 Query: 119 DLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR----IYSYQMALTPV 174 Q RG+ +L + +HRDL N+LVT +K+ADFGLAR I Y+ Sbjct: 134 SCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGR 193 Query: 175 VVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 + W APE L Y D+WS G + E+F Sbjct: 194 LPVKWM-APEALFDRVYTHQSDVWSFGILLWEIF 226 >2Q0N-A nrPDB Length = 301 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 75/288 (26%), Positives = 127/288 (44%), Gaps = 40/288 (13%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +IG G+ G V A SG VA+K + + EV ++R ++H N Sbjct: 36 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRE-----LLFNEVVIMR---DYQHEN 87 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 VV + + ++ +V E ++ T D + E I + L+ L Sbjct: 88 VVEMYNSYLVGD-----ELWVVMEFLEGGALT--DIVTHTRMNEEQIAAVCLAVLQALSV 140 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLWYRAPEVLLQS 189 LHA ++HRD+K ++IL+T G VKL+DFG S ++ +V T ++ APE++ + Sbjct: 141 LHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL 200 Query: 190 TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAF 249 Y VD+WS+G + EM +P + PP + + + R Sbjct: 201 PYGPEVDIWSLGIMVIEMVDGEPPYFNE---------------PPL----KAMKMIRDNL 241 Query: 250 PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 PPR + + V P ++ L +L +P +R +A L+H +L K Sbjct: 242 PPRL-KNLHKVSPSLK----GFLDRLLVRDPAQRATAAELLKHPFLAK 284 >4UYA-A nrPDB Length = 340 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 64/220 (29%), Positives = 91/220 (41%), Gaps = 27/220 (12%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRV-PNGGGGGGGLPISTVREVAL 59 +A R E IG G +G VY+A G VA+K+ R P +VR A Sbjct: 23 VAFERLELKELIGAGGFGQVYRA--TWQGQEVAVKAARQDPEQDAAAAA---ESVRREA- 76 Query: 60 LRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKD 119 R HPN++ L VC + + L F R + PP + + Sbjct: 77 -RLFAMLRHPNIIELRGVCLQ---QPHLCLVLEFARGGALNRALAGRRIPP----HVLVN 128 Query: 120 LMRQFLRGLDFLHANC---IVHRDLKPENILV--------TSGGTVKLADFGLARIYSYQ 168 Q RG+ +LH I+HRDLK NIL+ T+K+ DFGLAR + Sbjct: 129 WAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRT 188 Query: 169 MALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 + W APEV+ S ++ D+WS G + E+ Sbjct: 189 TKMATAGAYAWM-APEVIKSSLFSKGSDIWSYGVLLWELL 227 >4B8L-A nrPDB Length = 286 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 57/224 (25%), Positives = 102/224 (45%), Gaps = 13/224 (5%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G G +G VY AR+ + +ALK + G+ RE+ + L HPN+ Sbjct: 23 LGKGKFGNVYLAREKQNKFIMALKVLF--KSQLEKEGVEHQLRREIEIQSHLR---HPNI 77 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFL 131 +R+ + DR+ ++ L+ E + Y + + M + L + Sbjct: 78 LRMYNYFH----DRK-RIYLMLEFAPRG-ELYKELQKHGRFDEQRSATFMEELADALHYC 131 Query: 132 HANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTY 191 H ++HRD+KPEN+L+ G +K+ADFG + +++ + + TL Y PE++ T+ Sbjct: 132 HERKVIHRDIKPENLLMGYKGELKIADFGWS-VHAPSLRRRTMCGTLDYLPPEMIEGKTH 190 Query: 192 ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDL-IGLPP 234 VD+W G + E P F S + +I ++ + PP Sbjct: 191 DEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKFPP 234 >4JDH-A nrPDB Length = 346 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 75/288 (26%), Positives = 127/288 (44%), Gaps = 40/288 (13%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +IG G+ G V A SG VA+K + + EV ++R ++H N Sbjct: 81 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRE-----LLFNEVVIMR---DYQHEN 132 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 VV + + ++ +V E ++ T D + E I + L+ L Sbjct: 133 VVEMYNSYLVGD-----ELWVVMEFLEGGALT--DIVTHTRMNEEQIAAVCLAVLQALSV 185 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLWYRAPEVLLQS 189 LHA ++HRD+K ++IL+T G VKL+DFG S ++ +V T ++ APE++ + Sbjct: 186 LHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL 245 Query: 190 TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAF 249 Y VD+WS+G + EM +P + PP + + + R Sbjct: 246 PYGPEVDIWSLGIMVIEMVDGEPPYFNE---------------PPL----KAMKMIRDNL 286 Query: 250 PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 PPR + + V P ++ L +L +P +R +A L+H +L K Sbjct: 287 PPR-LKNLHKVSPSLK----GFLDRLLVRDPAQRATAAELLKHPFLAK 329 >4JG6-A nrPDB Length = 355 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 82/311 (26%), Positives = 132/311 (42%), Gaps = 59/311 (18%) Query: 3 TSRYEPVAEIGVGAYGT----VYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVA 58 T YE +IGVG+Y ++KA + + KS R P E+ Sbjct: 34 TDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPT-------------EEIE 80 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAE-TI 117 +L R +HPN++ L DV D V +V E + LDK +E Sbjct: 81 ILLRYG--QHPNIITLKDV-----YDDGKYVYVVTELMKGG--ELLDKILRQKFFSEREA 131 Query: 118 KDLMRQFLRGLDFLHANCIVHRDLKPENILVT--SGG--TVKLADFGLARIYSYQ--MAL 171 ++ + +++LHA +VHRDLKP NIL SG ++++ DFG A+ + + + Sbjct: 132 SAVLFTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLM 191 Query: 172 TPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG 231 TP T + APEVL + Y D+WS+G + M F Sbjct: 192 TP-CYTANFVAPEVLERQGYDAACDIWSLGVLLYTMLTGYTPFANGP------------- 237 Query: 232 LPPEDDWPRDV--SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 DD P ++ + G F G + ++ L+ +ML +PH+R++A Sbjct: 238 ----DDTPEEILARIGSGKFSLSG-----GYWNSVSDTAKDLVSKMLHVDPHQRLTAALV 288 Query: 290 LQHSYL-HKDE 299 L+H ++ H D+ Sbjct: 289 LRHPWIVHWDQ 299 >4C0T-A nrPDB Length = 974 Score = 73.2 bits (178), Expect = 1e-13, Method: Composition-based stats. Identities = 42/128 (32%), Positives = 60/128 (46%), Gaps = 10/128 (7%) Query: 112 LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI------- 164 L E + Q L + ++H N ++HRDLKPENIL+ +++ DFG AR+ Sbjct: 364 LNEECTRHFGAQILDAIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDE 423 Query: 165 ---YSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEAD 221 Y + V T Y +PE+L P D+W+ GCI +M KP F +E Sbjct: 424 SEEYPVDVRAKSFVGTAEYVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYL 483 Query: 222 QLGKIFDL 229 KI L Sbjct: 484 TFQKITKL 491 >3LLT-A nrPDB Length = 360 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 62/253 (24%), Positives = 96/253 (37%), Gaps = 50/253 (19%) Query: 89 VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILV 148 + L+FE + L + + G E IK + L+ L++L + H DLKPENIL+ Sbjct: 111 MCLIFEPLGPSLYEIITRNNYNGFHIEDIKLYCIEILKALNYLRKMSLTHTDLKPENILL 170 Query: 149 -------------------------TSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183 T +KL DFG A S ++ T YRAP Sbjct: 171 DDPYFEKSLITVRRVTDGKKIQIYRTKSTGIKLIDFGCATFKSDYHG--SIINTRQYRAP 228 Query: 184 EVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPED------- 236 EV+L + DMWS GC+ AE++ LF + + L + +I P++ Sbjct: 229 EVILNLGWDVSSDMWSFGCVLAELYTGSLLFRTHEHMEHLAMMESIIQPIPKNMLYEATK 288 Query: 237 --------------DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHK 282 WP + S + P+ ++ E L +L +P Sbjct: 289 TNGSKYVNKDELKLAWPENASSINSIKHVKKCLPLYKIIK--HELFCDFLYSILQIDPTL 346 Query: 283 RISAFRALQHSYL 295 R S L+H +L Sbjct: 347 RPSPAELLKHKFL 359 >3KN6-A nrPDB Length = 325 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 59/203 (29%), Positives = 93/203 (45%), Gaps = 24/203 (11%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G G++ K S A+K + + +T +E+ L+ E HPN+ Sbjct: 19 LGEGSFSICRKCVHKKSNQAFAVKII--------SKRMEANTQKEITALKLCEG--HPNI 68 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKD-LMRQFLRGLDF 130 V+L +V ++ LV E ++ ++ +ET +MR+ + + Sbjct: 69 VKLHEV-----FHDQLHTFLVMELLNGG--ELFERIKKKKHFSETEASYIMRKLVSAVSH 121 Query: 131 LHANCIVHRDLKPENILVTSGG---TVKLADFGLARIY--SYQMALTPVVVTLWYRAPEV 185 +H +VHRDLKPEN+L T +K+ DFG AR+ Q TP TL Y APE+ Sbjct: 122 MHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTP-CFTLHYAAPEL 180 Query: 186 LLQSTYATPVDMWSVGCIFAEMF 208 L Q+ Y D+WS+G I M Sbjct: 181 LNQNGYDESCDLWSLGVILYTML 203 >4OW8-A nrPDB Length = 283 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 64/218 (29%), Positives = 96/218 (44%), Gaps = 10/218 (4%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + RY I G G V++A D G VA+K ++ P R A R Sbjct: 10 SGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSD-----PEFIERFRAEART 64 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLM 121 HP + + D + LV E V+ + L + L + L D++ Sbjct: 65 TAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDML 122 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYSYQMALTPVVV-TLW 179 Q R L HA +VHRD+KP NIL+T G VK+ DFG+A+ + + + T +V+ T Sbjct: 123 EQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQ 182 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGN 217 Y APE L + D++S+G + E K F G+ Sbjct: 183 YIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGD 220 >4FIE-A nrPDB Length = 423 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 75/288 (26%), Positives = 127/288 (44%), Gaps = 40/288 (13%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +IG G+ G V A SG VA+K + + EV ++R ++H N Sbjct: 158 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRE-----LLFNEVVIMR---DYQHEN 209 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 VV + + ++ +V E ++ T D + E I + L+ L Sbjct: 210 VVEMYNSYLVGD-----ELWVVMEFLEGGALT--DIVTHTRMNEEQIAAVCLAVLQALSV 262 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLWYRAPEVLLQS 189 LHA ++HRD+K ++IL+T G VKL+DFG S ++ +V T ++ APE++ + Sbjct: 263 LHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL 322 Query: 190 TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAF 249 Y VD+WS+G + EM +P + PP + + + R Sbjct: 323 PYGPEVDIWSLGIMVIEMVDGEPPYFNE---------------PPL----KAMKMIRDNL 363 Query: 250 PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 PPR + + V P ++ L +L +P +R +A L+H +L K Sbjct: 364 PPRL-KNLHKVSPSLK----GFLDRLLVRDPAQRATAAELLKHPFLAK 406 >6B2Q-A nrPDB Length = 317 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 64/218 (29%), Positives = 96/218 (44%), Gaps = 10/218 (4%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + RY I G G V++A D G VA+K ++ P R A R Sbjct: 31 SGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSD-----PEFIERFRAEART 85 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLM 121 HP + + D + LV E V+ + L + L + L D++ Sbjct: 86 TAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDML 143 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYSYQMALTPVVV-TLW 179 Q R L HA +VHRD+KP NIL+T G VK+ DFG+A+ + + + T +V+ T Sbjct: 144 EQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQ 203 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGN 217 Y APE L + D++S+G + E K F G+ Sbjct: 204 YIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGD 241 >4X3F-A nrPDB Length = 337 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 64/218 (29%), Positives = 96/218 (44%), Gaps = 10/218 (4%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + RY I G G V++A D G VA+K ++ P R A R Sbjct: 11 SGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSD-----PEFIERFRAEART 65 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLM 121 HP + + D + LV E V+ + L + L + L D++ Sbjct: 66 TAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDML 123 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYSYQMALTPVVV-TLW 179 Q R L HA +VHRD+KP NIL+T G VK+ DFG+A+ + + + T +V+ T Sbjct: 124 EQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQ 183 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGN 217 Y APE L + D++S+G + E K F G+ Sbjct: 184 YIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGD 221 >3F3Z-A nrPDB Length = 277 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 63/243 (25%), Positives = 108/243 (44%), Gaps = 43/243 (17%) Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTL-----VFEHVDQDLRTYLDKAPPPGLPAETI 117 +++ +HPN++RL + + TD + + L +FE V R + + Sbjct: 60 MKSLDHPNIIRLYETFEDN-TDIYLVMELCTGGELFERVVHK-RVFRESDAA-------- 109 Query: 118 KDLMRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPV 174 +M+ L + + H + HRDLKPEN L + +KL DFGLA + + Sbjct: 110 -RIMKDVLSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTK 168 Query: 175 VVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 V T +Y +P+V L+ Y D WS G + + P F ++++ + KI + P Sbjct: 169 VGTPYYVSPQV-LEGLYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFP 227 Query: 235 EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294 E DW +V P+ E L+ +LT +P +RI++ +AL+H + Sbjct: 228 EKDW-------------------LNVSPQAE----SLIRRLLTKSPKQRITSLQALEHEW 264 Query: 295 LHK 297 K Sbjct: 265 FEK 267 >6BXI-A nrPDB Length = 333 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 70/281 (24%), Positives = 108/281 (38%), Gaps = 74/281 (26%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +E + IG GA+G V + +GH A+K +R+ +L + E Sbjct: 8 FESLKVIGRGAFGEVRLVQKKDTGHVYAMK-----------------ILRKADMLEK-EQ 49 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPG-------LPAETIK 118 H R + V A S + V +F L YL PG + +T+ Sbjct: 50 VGHIRAERDILVEADS-----LWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLT 104 Query: 119 DLMRQF-----LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLA----------- 162 + QF + +D +H +HRD+KP+N+L+ S G VKL+DFGL Sbjct: 105 EEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEF 164 Query: 163 ---------RIYSYQMALTPVVVTLW----------------YRAPEVLLQSTYATPVDM 197 +++Q + W Y APEV +Q+ Y D Sbjct: 165 YRNLNHSLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDW 224 Query: 198 WSVGCIFAEMFRRKPLFCGNSEADQLGKIFDL---IGLPPE 235 WS+G I EM P FC + + K+ + + PPE Sbjct: 225 WSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPE 265 >5IG1-A nrPDB Length = 344 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 73/289 (25%), Positives = 116/289 (40%), Gaps = 42/289 (14%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTV-REVALLRRLEAFEHPN 70 IG GA+ TV++ + +G A+K + + + I+ + RE+ + L+ H + Sbjct: 25 IGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSS----EINKIKREIGICSSLQ---HEH 77 Query: 71 VVRLMDVCATSRTDR-EIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 +V + R R E LVFE+V + + + M Q L L Sbjct: 78 IVSM------RRAFRDESHFYLVFEYVSGG-ELFDEIVTRKFYNEKDASACMHQILSALQ 130 Query: 130 FLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVL 186 H+ I+HRDLKPEN+L+ S VK+ DFGLA I T Y +PEV+ Sbjct: 131 HCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVI 190 Query: 187 LQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPR 246 + Y T VD+W+ G I + P F +I + P +W Sbjct: 191 RRVPYDTAVDVWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEW-------- 242 Query: 247 GAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 + + +L+ ML NP +R + LQH ++ Sbjct: 243 ---------------DSVTTAAKELIKAMLEPNPKRRPTVQELLQHPWI 276 >4TNB-A nrPDB Length = 590 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 43/121 (35%), Positives = 59/121 (48%) Query: 99 DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLAD 158 DL+ ++ PG E + L GL+ LH V+RDLKPENIL+ G ++++D Sbjct: 270 DLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHENTVYRDLKPENILLDDYGHIRISD 329 Query: 159 FGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNS 218 GLA + V T+ Y APEVL Y D W +GC+ EM + F G Sbjct: 330 LGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRK 389 Query: 219 E 219 E Sbjct: 390 E 390 >2OU7-A nrPDB Length = 335 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 38/95 (40%), Positives = 53/95 (55%), Gaps = 1/95 (1%) Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLW 179 +RQ + G +LH N ++HRDLK N+ + VK+ DFGLA Y V+ T Sbjct: 147 LRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPN 206 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLF 214 Y APEVL + ++ VD+WS+GCI + KP F Sbjct: 207 YIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPF 241 >3ZUT-A nrPDB Length = 362 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 64/214 (29%), Positives = 92/214 (42%), Gaps = 28/214 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + RYE V +IG G +G RD S VA+K + G + + RE+ R Sbjct: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIE------RGEKIDENVKREIINHRS 71 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTL-----VFEHVDQDLRTYLDKAPPPGLPAETI 117 L HPN+VR +V T T I + +FE + R D+A Sbjct: 72 LR---HPNIVRFKEVILTP-THLAIVMEYASGGELFERICNAGRFSEDEA---------- 117 Query: 118 KDLMRQFLRGLDFLHANCIVHRDLKPENILV--TSGGTVKLADFGLARIYSYQMALTPVV 175 + +Q + G+ + HA + HRDLK EN L+ + +K+ FG ++ V Sbjct: 118 RFFFQQLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTV 177 Query: 176 VTLWYRAPEVLLQSTYATPV-DMWSVGCIFAEMF 208 T Y APEVLL+ Y V D+WS G M Sbjct: 178 GTPAYIAPEVLLKKEYDGKVADVWSCGVTLYVML 211 >3DB8-A nrPDB Length = 317 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 37/96 (38%), Positives = 54/96 (56%), Gaps = 1/96 (1%) Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TL 178 MRQ ++G+ +LH N ++HRDLK N+ + VK+ DFGLA + + T Sbjct: 147 FMRQTIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTP 206 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLF 214 Y APEVL + ++ VD+WS+GCI + KP F Sbjct: 207 NYIAPEVLCKKGHSFEVDIWSLGCILYTLLVGKPPF 242 >6FER-A nrPDB Length = 309 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 55/207 (26%), Positives = 93/207 (44%), Gaps = 30/207 (14%) Query: 31 FVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVT 90 VA+K +R ++E+ ++ RL+ PN++ L+ VC T + + Sbjct: 52 LVAVKMLRADANKNARNDF----LKEIKIMSRLK---DPNIIHLLAVCIT-----DDPLC 99 Query: 91 LVFEHVDQ-DLRTYLDKAPPPGLPAE--------TIKDLMRQFLRGLDFLHANCIVHRDL 141 ++ E+++ DL +L + PP + +K + Q G+ +L + VHRDL Sbjct: 100 MITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDL 159 Query: 142 KPENILVTSGGTVKLADFGLAR-IYS---YQMALTPVVVTLWYRAPEVLLQSTYATPVDM 197 N LV T+K+ADFG++R +YS Y++ V+ W +LL + T D+ Sbjct: 160 ATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILL-GKFTTASDV 218 Query: 198 WSVGCIFAEMFRRKPLFCGNSEADQLG 224 W+ G E F FC QL Sbjct: 219 WAFGVTLWETFT----FCQEQPYSQLS 241 >4J52-A nrPDB Length = 293 Score = 70.9 bits (172), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 38/95 (40%), Positives = 53/95 (55%), Gaps = 1/95 (1%) Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLW 179 +RQ + G +LH N ++HRDLK N+ + VK+ DFGLA Y V+ T Sbjct: 120 LRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPN 179 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLF 214 Y APEVL + ++ VD+WS+GCI + KP F Sbjct: 180 YIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPF 214 >3UC3-A nrPDB Length = 361 Score = 70.9 bits (172), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 89/209 (42%), Gaps = 18/209 (8%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + RY+ V +IG G +G RD + VA+K + G + + RE+ R Sbjct: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIE------RGAAIDENVQREIINHRS 72 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L HPN+VR +V T + ++ E+ Y + + + Sbjct: 73 LR---HPNIVRFKEVILTP-----THLAIIMEYASGG-ELYERICNAGRFSEDEARFFFQ 123 Query: 123 QFLRGLDFLHANCIVHRDLKPENILV--TSGGTVKLADFGLARIYSYQMALTPVVVTLWY 180 Q L G+ + H+ I HRDLK EN L+ + +K+ DFG ++ V T Y Sbjct: 124 QLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAY 183 Query: 181 RAPEVLLQSTYATPV-DMWSVGCIFAEMF 208 APEVLL+ Y + D+WS G M Sbjct: 184 IAPEVLLRQEYDGKIADVWSCGVTLYVML 212 >5WAX-A nrPDB Length = 310 Score = 70.9 bits (172), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 62/212 (29%), Positives = 93/212 (43%), Gaps = 28/212 (13%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 RYE V +IG G +G R+ G VA+K + G + + RE+ R L Sbjct: 12 RYELVRDIGSGNFGVARLMRNRADGQLVAVKYIE------RGEKIDENVQREIINHRSLR 65 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTL-----VFEHVDQDLRTYLDKAPPPGLPAETIKD 119 HPN++R +V T T I + +FE + R D+A + Sbjct: 66 ---HPNIIRFKEVILTP-THLAIVMEYASGGELFERICNAGRFSEDEA----------RF 111 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILV--TSGGTVKLADFGLARIYSYQMALTPVVVT 177 +Q + G+ + H+ + HRDLK EN L+ ++ +K+ DFG ++ V T Sbjct: 112 FFQQLISGVSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGT 171 Query: 178 LWYRAPEVLLQSTYATPV-DMWSVGCIFAEMF 208 Y APEVLL+ Y V D+WS G M Sbjct: 172 PAYIAPEVLLKKEYDGKVADVWSCGVTLYVML 203 >5VD3-A nrPDB Length = 311 Score = 70.5 bits (171), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 68/231 (29%), Positives = 97/231 (41%), Gaps = 18/231 (7%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 ++ ++ +G G+YG V+K R G A+K P G P R++A + E Sbjct: 59 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRG------PKDRARKLAEVGSHEK 112 Query: 66 F-EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 +HP VRL + L E L+ + + A LP + +R Sbjct: 113 VGQHPCCVRLEQAWEEGGI-----LYLQTELCGPSLQQHCE-AWGASLPEAQVWGYLRDT 166 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 L L LH+ +VH D+KP NI + G KL DFGL A Y APE Sbjct: 167 LLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPE 226 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPE 235 LLQ +Y T D++S+G E+ L G QL + + LPPE Sbjct: 227 -LLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGY----LPPE 272 >4AF3-A nrPDB Length = 292 Score = 70.5 bits (171), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 63/238 (26%), Positives = 108/238 (45%), Gaps = 21/238 (8%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G G +G VY AR+ S VALK + G+ RE+ + L HPN+ Sbjct: 31 LGKGKFGNVYLAREKKSHFIVALKVLF--KSQIEKEGVEHQLRREIEIQAHLH---HPNI 85 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 +RL + R ++ L+ E+ + +L L K+ + +M + L + Sbjct: 86 LRLYNYFYDRR-----RIYLILEYAPRGELYKELQKSC--TFDEQRTATIMEELADALMY 138 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQST 190 H ++HRD+KPEN+L+ G +K+ADFG + +++ + + TL Y PE++ Sbjct: 139 CHGKKVIHRDIKPENLLLGLKGELKIADFGWS-VHAPSLRRKTMCGTLDYLPPEMIEGRM 197 Query: 191 YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGA 248 + VD+W +G + E+ P F S + +I + D S+P GA Sbjct: 198 HNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKV-------DLKFPASVPTGA 248 >5MJB-A nrPDB Length = 305 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 64/240 (26%), Positives = 103/240 (42%), Gaps = 26/240 (10%) Query: 12 IGVGAYGTVYKARDPHSGH---FVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 IG G +G VYK R G +VA+K+++ G + E +++ + F+H Sbjct: 34 IGAGEFGEVYKGRLKLPGKREIYVAIKTLK----AGYSEKQRRDFLSEASIMGQ---FDH 86 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 N++RL V SR V ++ E ++ + + ++R G+ Sbjct: 87 RNIIRLEGVVTKSRP-----VMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRGIAAGM 141 Query: 129 DFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-------SYQMALTPVVVTLWYR 181 +L VHRDL NILV S K++DFGL+R +Y +L + W Sbjct: 142 KYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRW-T 200 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEM--FRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 APE + + + D+WS G + E+ F +P + S D + I LPP D P Sbjct: 201 APEAIAYRKFTSASDVWSYGIVMWEVMSFGERP-YWDMSNQDVINAIEQDYRLPPPMDCP 259 >2PL0-A nrPDB Length = 289 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 55/203 (27%), Positives = 95/203 (46%), Gaps = 21/203 (10%) Query: 9 VAEIGVGAYGTVYKARDPHSGHF-VALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 V +G G +G V+ ++GH VA+KS++ G P + + E L+++L+ Sbjct: 28 VERLGAGQFGEVWMGY--YNGHTKVAVKSLK------QGSMSPDAFLAEANLMKQLQ--- 76 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLR 126 H +VRL V + ++ E+++ L +L L + D+ Q Sbjct: 77 HQRLVRLYAVVTQE------PIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAE 130 Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY--SYQMALTPVVVTLWYRAPE 184 G+ F+ +HRDL+ NILV+ + K+ADFGLAR+ + A + + APE Sbjct: 131 GMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPE 190 Query: 185 VLLQSTYATPVDMWSVGCIFAEM 207 + T+ D+WS G + E+ Sbjct: 191 AINYGTFTIKSDVWSFGILLTEI 213 >2RIO-A nrPDB Length = 434 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 72/273 (26%), Positives = 124/273 (45%), Gaps = 70/273 (25%) Query: 56 EVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPA 114 E+ LL E+ +HPNV+R C+ + TDR + + L +++ QDL + Sbjct: 58 EIKLLT--ESDDHPNVIRY--YCSET-TDRFLYIALELCNLNLQDL------VESKNVSD 106 Query: 115 ETIK--------DLMRQFLRGLDFLHANCIVHRDLKPENILVTSGG-------------T 153 E +K L+RQ G+ LH+ I+HRDLKP+NILV++ Sbjct: 107 ENLKLQKEYNPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLR 166 Query: 154 VKLADFGLARIY-----SYQMALTPVVVTLWYRAPEVLLQST-------YATPVDMWSVG 201 + ++DFGL + S++ L T +RAPE+L +S +D++S+G Sbjct: 167 ILISDFGLCKKLDSGQSSFRTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMG 226 Query: 202 CIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPV--QS 259 C+F + + GK P D + R+ ++ RG F + + +S Sbjct: 227 CVFYYILSK-------------GK------HPFGDKYSRESNIIRGIFSLDEMKCLHDRS 267 Query: 260 VVPEMEESGAQLLLEMLTFNPHKRISAFRALQH 292 ++ E L+ +M+ +P KR +A + L+H Sbjct: 268 LIAE----ATDLISQMIDHDPLKRPTAMKVLRH 296 >4E20-A nrPDB Length = 290 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 67/239 (28%), Positives = 107/239 (44%), Gaps = 30/239 (12%) Query: 4 SRY-EPVAEIGVGAYGTV----YKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVA 58 RY + + ++G G +G V Y + +G VA+K+++ G G L RE+ Sbjct: 7 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALK----EGCGPQLRSGWQREIE 62 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETI 117 +LR L H ++V+ C E V LV E+V LR YL P + + Sbjct: 63 ILRTLY---HEHIVKYKGCC---EDQGEKSVQLVMEYVPLGSLRDYL---PRHCVGLAQL 113 Query: 118 KDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-----SYQMALT 172 +Q G+ +LHA +HR L N+L+ + VK+ DFGLA+ Y++ Sbjct: 114 LLFAQQICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVRED 173 Query: 173 PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG 231 WY APE L + + D+WS G E+ +C ++++ K +LIG Sbjct: 174 GDSPVFWY-APECLKECKFYYASDVWSFGVTLYELL----TYCDSNQSPHT-KFTELIG 226 >3TXO-A nrPDB Length = 353 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 68/240 (28%), Positives = 103/240 (42%), Gaps = 33/240 (13%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + +E + +G G++G V AR +G A+K ++ T + + L Sbjct: 20 LGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSL 79 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVT-------LVFEHVDQDLRTYLDKAPPPGLP 113 R HP + +L C DR V L+F H+ + R D+A Sbjct: 80 AR----NHPFLTQLF--CCFQTPDRLFFVMEFVNGGDLMF-HIQKSRR--FDEARARFYA 130 Query: 114 AETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTP 173 AE I LM FLH I++RDLK +N+L+ G KLADFG+ + T Sbjct: 131 AEIISALM--------FLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTA 182 Query: 174 VVV-TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNS--EADQLGKIFDLI 230 T Y APE+L + Y VD W++G + EM CG++ EA+ +F+ I Sbjct: 183 TFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEM------LCGHAPFEAENEDDLFEAI 236 >5O0Y-A nrPDB Length = 579 Score = 69.7 bits (169), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 72/242 (29%), Positives = 110/242 (45%), Gaps = 30/242 (12%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNG--GGGGGGLPISTVREVALL 60 RY + +G G + VYKA D +VA+K ++ RE + Sbjct: 283 NDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIH 342 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKD 119 + L+ HP +V+L D + TD V E+ + DL YL + + + + Sbjct: 343 KELD---HPRIVKLYDYFSLD-TD---SFCTVLEYCEGNDLDFYLKQHKL--MSEKEARS 393 Query: 120 LMRQFLRGLDFLHANC--IVHRDLKPENILVTSG---GTVKLADFGLARIY---SYQ--- 168 ++ Q + L +L+ I+H DLKP NIL+ +G G +K+ DFGL++I SY Sbjct: 394 IIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVD 453 Query: 169 -MALTPV-VVTLWYRAPEVLLQS----TYATPVDMWSVGCIFAE-MFRRKPLFCGNSEAD 221 M LT T WY PE + + VD+WSVG IF + ++ RKP S+ D Sbjct: 454 GMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQD 513 Query: 222 QL 223 L Sbjct: 514 IL 515 >3HDN-A nrPDB Length = 373 Score = 69.7 bits (169), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 67/226 (29%), Positives = 97/226 (42%), Gaps = 27/226 (11%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 IG G++G V AR F A+K ++ I + R V L + +HP + Sbjct: 46 IGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLL----KNVKHPFL 101 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVD--------QDLRTYLDKAPPPGLPAETIKDLMRQ 123 V L T+ K+ V ++++ Q R +L+ P A I Sbjct: 102 VGLHFSFQTAD-----KLYFVLDYINGGELFYHLQRERCFLE--PRARFYAAEIAS---- 150 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLWYRA 182 L +LH+ IV+RDLKPENIL+ S G + L DFGL + + T T Y A Sbjct: 151 ---ALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLA 207 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD 228 PEVL + Y VD W +G + EM P F + A+ I + Sbjct: 208 PEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN 253 >5X02-A nrPDB Length = 347 Score = 69.7 bits (169), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 67/229 (29%), Positives = 99/229 (43%), Gaps = 45/229 (19%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF----E 67 +G GA+G V A + + ++ V + S+ RE AL+ L+ Sbjct: 56 LGSGAFGKVMNA----TAYGISKTGVSIQVAVKMLKEKADSSERE-ALMSELKMMTQLGS 110 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYL----DKAPPPGLPAE------- 115 H N+V L+ C S + L+FE+ DL YL +K + E Sbjct: 111 HENIVNLLGACTLSGP-----IYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEE 165 Query: 116 -------TIKDLM---RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY 165 T +DL+ Q +G++FL VHRDL N+LVT G VK+ DFGLAR Sbjct: 166 EEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDI 225 Query: 166 SYQMALTPVVVT------LWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 M+ + VV + + APE L + Y D+WS G + E+F Sbjct: 226 ---MSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIF 271 >3OMV-A nrPDB Length = 307 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 67/232 (28%), Positives = 99/232 (42%), Gaps = 49/232 (21%) Query: 12 IGVGAYGTVYKAR-------------DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVA 58 IG G++GTVYK + DP F A ++ EVA Sbjct: 44 IGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRN-------------------EVA 84 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIK 118 +LR+ H N++ M D VT E L +L + I Sbjct: 85 VLRKTR---HVNILLFMGYMTK---DNLAIVTQWCE--GSSLYKHLHVQETKFQMFQLI- 135 Query: 119 DLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS----YQMALTPV 174 D+ RQ +G+D+LHA I+HRD+K NI + G TVK+ DFGLA + S Q P Sbjct: 136 DIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPT 195 Query: 175 VVTLWYRAPEVL-LQST--YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQL 223 LW APEV+ +Q ++ D++S G + E+ + + + DQ+ Sbjct: 196 GSVLWM-APEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQI 246 >2HW6-A nrPDB Length = 307 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 76/302 (25%), Positives = 122/302 (40%), Gaps = 39/302 (12%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G GAY V A +G A+K + G REV L + + + N+ Sbjct: 21 LGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRS-----RVFREVETLYQCQG--NKNI 73 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 + L++ + + + LVFE + + ++ K ++R LDF Sbjct: 74 LELIEF-----FEDDTRFYLVFEKLQGGSILAHIQKQKH--FNEREASRVVRDVAAALDF 126 Query: 131 LHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVV--------TLW 179 LH I HRDLKPENIL S VK+ DF L + TP+ + Sbjct: 127 LHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAE 186 Query: 180 YRAPEVLL----QST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 Y APEV+ Q+T Y D+WS+G + M P F G+ AD G + Sbjct: 187 YMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGAD-CGWDRGEVCRVC 245 Query: 235 EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294 ++ + + FP + + S L+ ++L + +R+SA + LQH + Sbjct: 246 QNKLFESIQEGKYEFPDKDWAHISS-------EAKDLISKLLVRDAKQRLSAAQVLQHPW 298 Query: 295 LH 296 + Sbjct: 299 VQ 300 >5L6P-A nrPDB Length = 298 Score = 68.9 bits (167), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 63/240 (26%), Positives = 104/240 (43%), Gaps = 26/240 (10%) Query: 12 IGVGAYGTVYKARDPHSGH---FVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 IG G +G V + R G FVA+K+++V G + E +++ + F+H Sbjct: 27 IGAGEFGEVCRGRLKQPGRREVFVAIKTLKV----GYTERQRRDFLSEASIMGQ---FDH 79 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 PN++RL V SR V ++ E ++ + + ++R G+ Sbjct: 80 PNIIRLEGVVTKSRP-----VMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGM 134 Query: 129 DFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-------SYQMALTPVVVTLWYR 181 +L VHRDL NILV S K++DFGL+R +Y +L + W Sbjct: 135 KYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRW-T 193 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEM--FRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 APE + + + D+WS G + E+ + +P + S D + + LPP D P Sbjct: 194 APEAIAYRKFTSASDVWSYGIVMWEVMSYGERP-YWDMSNQDVINAVEQDYRLPPPMDCP 252 >5LOH-A nrPDB Length = 341 Score = 68.9 bits (167), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 67/260 (25%), Positives = 112/260 (43%), Gaps = 45/260 (17%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 + + V I GA+G VY + G A+K V+ + + R+ L Sbjct: 34 SIEEFSIVKPISRGAFGKVYLGQK--GGKLYAVKVVKKADMINKNMTHQVQAERDALALS 91 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEH-VDQDLRT------YLDKAPPPGLPA 114 + P +V L ++ V LV E+ + D+++ Y D+ Sbjct: 92 K-----SPFIVHLYYSLQSANN-----VYLVMEYLIGGDVKSLLHIYGYFDE-------- 133 Query: 115 ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-YSYQMALTP 173 E + + LD+LH + I+HRDLKP+N+L+++ G +KL DFGL+++ + + + Sbjct: 134 EMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMD 193 Query: 174 VVVTLW------YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIF 227 ++ T Y APE+LL + VD W++G E P F N E Q ++F Sbjct: 194 ILTTRTFCGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPF--NDETPQ--QVF 249 Query: 228 DLIGLPPEDDWPRDVSLPRG 247 I RD+ P G Sbjct: 250 QNI-------LKRDIPWPEG 262 >4XUF-A nrPDB Length = 297 Score = 68.9 bits (167), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 67/229 (29%), Positives = 99/229 (43%), Gaps = 45/229 (19%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF----E 67 +G GA+G V A + + ++ V + S+ RE AL+ L+ Sbjct: 17 LGSGAFGKVMNA----TAYGISKTGVSIQVAVKMLKEKADSSERE-ALMSELKMMTQLGS 71 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYL----DKAPPPGLPAE------- 115 H N+V L+ C S + L+FE+ DL YL +K + E Sbjct: 72 HENIVNLLGACTLSGP-----IYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLEE 126 Query: 116 -------TIKDLM---RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY 165 T +DL+ Q +G++FL VHRDL N+LVT G VK+ DFGLAR Sbjct: 127 EEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDI 186 Query: 166 SYQMALTPVVVT------LWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 M+ + VV + + APE L + Y D+WS G + E+F Sbjct: 187 ---MSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIF 232 >4HVI-A nrPDB Length = 314 Score = 68.6 bits (166), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 60/209 (28%), Positives = 101/209 (48%), Gaps = 21/209 (10%) Query: 9 VAEIGVGAYGTVYKAR-DP---HSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 ++++G G +G+V R DP ++G VA+K ++ G RE+ +L+ L Sbjct: 15 ISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQ-----HSGPDQQRDFQREIQILKALH 69 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLMRQ 123 + +V+ V S + LV E++ LR +L + L A + Q Sbjct: 70 S---DFIVKYRGV---SYGPGRQSLRLVMEYLPSGCLRDFLQRHRA-RLDASRLLLYSSQ 122 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALTPVVVTLW 179 +G+++L + VHRDL NILV S VK+ADFGLA++ Y + P ++ Sbjct: 123 ICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIF 182 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 + APE L + ++ D+WS G + E+F Sbjct: 183 WYAPESLSDNIFSRQSDVWSFGVVLYELF 211 >5IKW-A nrPDB Length = 310 Score = 68.6 bits (166), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 65/229 (28%), Positives = 102/229 (44%), Gaps = 35/229 (15%) Query: 1 MATSRYEPVAE--IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTV--RE 56 A R++ E + G + TV+ R H G ALK + V N +P V RE Sbjct: 9 FAVGRHQVTLEESLAEGGFSTVFLVR-THGGIRCALKRMYVNN-------MPDLNVCKRE 60 Query: 57 VALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAE 115 + +++ L H N+V +D S +D +V ++ E+ + ++K G Sbjct: 61 ITIMKELSG--HKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEP 118 Query: 116 TIKDLMRQFLRGLDFLHANC---IVHRDLKPENILVTSGGTVKLADFGLA--RIYSYQMA 170 + + + LH C I+HRDLK ENIL+ GG L DFG A + + Q Sbjct: 119 EVLQIFCDTCEAVARLH-QCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKD 177 Query: 171 LTPVV-------VTLWYRAPEVLLQSTY-----ATPVDMWSVGCIFAEM 207 VV TL YRAPE++ + Y T D+W++GC+ ++ Sbjct: 178 GVNVVEEEIKKYTTLSYRAPEMI--NLYGGKPITTKADIWALGCLLYKL 224 >3QUP-A nrPDB Length = 323 Score = 68.2 bits (165), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 59/212 (27%), Positives = 98/212 (46%), Gaps = 20/212 (9%) Query: 12 IGVGAYGTVYKAR-DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +G G +G+V +A+ G FV + +V++ +RE A ++ F+HP+ Sbjct: 31 LGKGEFGSVREAQLKQEDGSFVKV-AVKMLKADIIASSDIEEFLREAACMKE---FDHPH 86 Query: 71 VVRLMDVCATSRTDREIKVTLV----FEHVDQDLRTYLDKA----PPPGLPAETIKDLMR 122 V +L+ V SR + + +V +H DL +L + P LP +T+ M Sbjct: 87 VAKLVGVSLRSRAKGRLPIPMVILPFMKH--GDLHAFLLASRIGENPFNLPLQTLVRFMV 144 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYS---YQMALTPVVVTL 178 G+++L + +HRDL N ++ TV +ADFGL+R IYS Y+ + Sbjct: 145 DIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVK 204 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRR 210 W A E L + Y D+W+ G E+ R Sbjct: 205 WL-ALESLADNLYTVHSDVWAFGVTMWEIMTR 235 >6DBM-A nrPDB Length = 318 Score = 68.2 bits (165), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 63/240 (26%), Positives = 107/240 (44%), Gaps = 30/240 (12%) Query: 4 SRY-EPVAEIGVGAYGTV----YKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVA 58 RY + + ++G G +G V Y + +G VA+K+++ G G +E+ Sbjct: 30 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSGWK----QEID 85 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETI 117 +LR L H ++++ C + + LV E+V LR YL P + + Sbjct: 86 ILRTLY---HEHIIKYKGCCEDAGA---ASLQLVMEYVPLGSLRDYL---PRHSIGLAQL 136 Query: 118 KDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-----SYQMALT 172 +Q G+ +LH+ +HRDL N+L+ + VK+ DFGLA+ Y++ Sbjct: 137 LLFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVRED 196 Query: 173 PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGL 232 WY APE L + + D+WS G E+ C +S++ K +LIG+ Sbjct: 197 GDSPVFWY-APECLKEYKFYYASDVWSFGVTLYELLTH----CDSSQSPPT-KFLELIGI 250 >5TOS-A nrPDB Length = 395 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 85/326 (26%), Positives = 139/326 (42%), Gaps = 47/326 (14%) Query: 1 MATSRYEPVAEIGVGAYGTVYKA---------RDPHSGHFVALKSVRVPNGGGGGGGLPI 51 +AT + P + IG G +G V+K P +G +A+K + N G G Sbjct: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL---NQEGFQGHREW 118 Query: 52 STVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDK--AP 108 T E+ L +L HPN+V+L+ C + E ++ LV+E + + L +L + A Sbjct: 119 LT--EINYLGQLS---HPNLVKLIGYC----LEDEHRL-LVYEFMQKGSLENHLFRRGAY 168 Query: 109 PPGLPAETIKDLMRQFLRGLDFLHAN--CIVHRDLKPENILVTSGGTVKLADFGLAR--- 163 LP ++ +GL FLH++ +++RD+K NIL+ + KL+DFGLAR Sbjct: 169 FKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGP 228 Query: 164 IYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQL 223 + T V+ T Y APE + D++S G + E+ K N A + Sbjct: 229 MGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEE 288 Query: 224 GKIFDLIGLPPEDDWPRD-VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHK 282 + DW R ++ R R +PE A + ++ L+F P Sbjct: 289 NLV----------DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKS 338 Query: 283 R------ISAFRALQHSYLHKDEGNP 302 R + A + LQ + + NP Sbjct: 339 RPTMDQVVRALQQLQDNLGKPSQTNP 364 >4TPT-A nrPDB Length = 303 Score = 67.8 bits (164), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 55/219 (25%), Positives = 96/219 (43%), Gaps = 39/219 (17%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKS-VRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +G G +G K +G + +K +R + + EV ++R L+ HPN Sbjct: 8 LGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQK------TFLTEVKVMRSLD---HPN 58 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 V++ + V + K+ L+ E+++ L+ +L P P + + G+ Sbjct: 59 VLKFIGVLYKDK-----KLNLLTEYIEGGTLKDFLRSMDP--FPWQQKVRFAKGIASGMA 111 Query: 130 FLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTP---------------- 173 +LH+ CI+HRDL N L+ TV +ADFGL+R+ + P Sbjct: 112 YLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKNDR 171 Query: 174 -----VVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEM 207 VV ++ APE+L +Y VD++S G + E+ Sbjct: 172 KKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEI 210 >5GRN-A nrPDB Length = 356 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 37/116 (31%), Positives = 58/116 (50%), Gaps = 3/116 (2%) Query: 96 VDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVK 155 +D +++ L GL + Q RG++FL + VHRDL N+L+ G VK Sbjct: 157 LDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVK 216 Query: 156 LADFGLARIY---SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 + DFGLAR S ++ + + + APE + + Y T D+WS G + E+F Sbjct: 217 ICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIF 272 >3NYO-A nrPDB Length = 576 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 38/109 (34%), Positives = 55/109 (50%) Query: 99 DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLAD 158 DL+ ++ G P + GL+ LH IV+RDLKPENIL+ G ++++D Sbjct: 270 DLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISD 329 Query: 159 FGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEM 207 GLA + V T+ Y APEV+ Y D W++GC+ EM Sbjct: 330 LGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEM 378 >4RA4-A nrPDB Length = 355 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 36/103 (34%), Positives = 54/103 (52%), Gaps = 1/103 (0%) Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLWYRAPEV 185 GL FLH I++RDLK +N+++ S G +K+ADFG+ + + T T Y APE+ Sbjct: 133 GLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEI 192 Query: 186 LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD 228 + Y VD W+ G + EM +P F G E + I + Sbjct: 193 IAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIME 235 >4OLI-A nrPDB Length = 645 Score = 67.4 bits (163), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 63/239 (26%), Positives = 107/239 (44%), Gaps = 30/239 (12%) Query: 5 RY-EPVAEIGVGAYGTV----YKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVAL 59 RY + + ++G G +G V Y + +G VA+K+++ G G +E+ + Sbjct: 353 RYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWK----QEIDI 408 Query: 60 LRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIK 118 LR L H ++++ C E + LV E+V LR YL P + + Sbjct: 409 LRTLY---HEHIIKYKGCC---EDQGEKSLQLVMEYVPLGSLRDYL---PRHSIGLAQLL 459 Query: 119 DLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-----SYQMALTP 173 +Q G+ +LH+ +HR+L N+L+ + VK+ DFGLA+ Y++ Sbjct: 460 LFAQQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDG 519 Query: 174 VVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGL 232 WY APE L + + D+WS G E+ C +S++ K +LIG+ Sbjct: 520 DSPVFWY-APECLKEYKFYYASDVWSFGVTLYELLTH----CDSSQSPPT-KFLELIGI 572 >3UIM-A nrPDB Length = 326 Score = 67.4 bits (163), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 68/242 (28%), Positives = 101/242 (41%), Gaps = 28/242 (11%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 +A+ + +G G +G VYK R G VA+K R+ GG L T E+ Sbjct: 27 VASDNFSNKNILGRGGFGKVYKGR-LADGTLVAVK--RLKEERTQGGELQFQTEVEM--- 80 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 + H N++RL C T + + V LR + PP P + + Sbjct: 81 --ISMAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKR--QRI 136 Query: 121 MRQFLRGLDFLHANC---IVHRDLKPENILVTSGGTVKLADFGLARIYSYQ--MALTPVV 175 RGL +LH +C I+HRD+K NIL+ + DFGLA++ Y+ T V Sbjct: 137 ALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVR 196 Query: 176 VTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPE 235 T+ + APE L + D++ G + E L G + FDL L + Sbjct: 197 GTIGHIAPEYLSTGKSSEKTDVFGYGVMLLE------LITGQ-------RAFDLARLAND 243 Query: 236 DD 237 DD Sbjct: 244 DD 245 >5U6C-A nrPDB Length = 315 Score = 67.4 bits (163), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 58/215 (26%), Positives = 99/215 (46%), Gaps = 27/215 (12%) Query: 12 IGVGAYGTVYKA---RDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR----LE 64 +G G +G+V + ++ + VA+K++++ N S+ RE+ ++ Sbjct: 44 LGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDN----------SSQREIEEFLSEAACMK 93 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLD----KAPPPGLPAETIKD 119 F HPNV+RL+ VC + K ++ + DL TYL + P +P +T+ Sbjct: 94 DFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLK 153 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLA-RIYS---YQMALTPVV 175 M G+++L +HRDL N ++ TV +ADFGL+ +IYS Y+ + Sbjct: 154 FMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKM 213 Query: 176 VTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRR 210 W A E L Y + D+W+ G E+ R Sbjct: 214 PVKWI-AIESLADRVYTSKSDVWAFGVTMWEIATR 247 >4I6B-A nrPDB Length = 308 Score = 67.4 bits (163), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 55/211 (26%), Positives = 93/211 (44%), Gaps = 12/211 (5%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 RY +G G + Y+ D + A K + P+ +E+ L R L Sbjct: 29 RYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKII--PHSRVSKPHQREKIDKEIELHRILH 86 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 H +VV+ D+E + ++ E+ + ++ KA L ++ +RQ Sbjct: 87 ---HKHVVQFYHYFE----DKE-NIYILLEYCSRRSMAHILKARKV-LTEPEVRYYLRQI 137 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGL-ARIYSYQMALTPVVVTLWYRAP 183 + GL +LH I+HRDLK N + +K+ DFGL AR+ + + T Y +P Sbjct: 138 VSGLKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSP 197 Query: 184 EVLLQSTYATPVDMWSVGCIFAEMFRRKPLF 214 EVL + + D+W++GC+ M +P F Sbjct: 198 EVLNKQGHGAESDIWALGCVMYTMLLGRPPF 228 >4PL5-B nrPDB Length = 435 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 58/163 (35%), Positives = 86/163 (52%), Gaps = 22/163 (13%) Query: 55 REVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPA 114 REV LLR E+ EHPNV+R + DR+ + + E L+ Y+++ L Sbjct: 69 REVQLLR--ESDEHPNVIRYF----CTEKDRQFQY-IAIELCAATLQEYVEQKDFAHLGL 121 Query: 115 ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT---SGGTVK--LADFGLARI----- 164 E I L+ Q GL LH+ IVHRDLKP NIL++ + G +K ++DFGL + Sbjct: 122 EPIT-LLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGR 180 Query: 165 YSYQMALTPVVVTLWYRAPEVLLQSTYATP---VDMWSVGCIF 204 +S+ + V T + APE+L + P VD++S GC+F Sbjct: 181 HSFSRR-SGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVF 222 >5KMM-A nrPDB Length = 329 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 68/236 (28%), Positives = 104/236 (44%), Gaps = 40/236 (16%) Query: 11 EIGVGAYGTVYKARD-----PHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 E+G GA+G V+ A VA+K+++ + RE LL L+ Sbjct: 42 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA-----RQDFQREAELLTMLQ- 95 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYL--------------DKAPPP 110 H ++VR VC R + +VFE++ DL +L D AP P Sbjct: 96 --HQHIVRFFGVCTEGRP-----LLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGP 148 Query: 111 GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYS--Y 167 L + + Q G+ +L VHRDL N LV G VK+ DFG++R IYS Y Sbjct: 149 -LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDY 207 Query: 168 QMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR--RKPLF-CGNSEA 220 ++ + + PE +L + T D+WS G + E+F ++P + N+EA Sbjct: 208 YRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA 263 >5LPZ-A nrPDB Length = 332 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 64/220 (29%), Positives = 101/220 (45%), Gaps = 25/220 (11%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVRE-VALL 60 AT+ + + IG G +G VYKA G VA+K + +G G RE +A + Sbjct: 15 ATNGFHNDSLIGSGGFGDVYKAI-LKDGSAVAIKKLIHVSGQGD---------REFMAEM 64 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPG--LPAETI 117 + +H N+V L+ C D + LV+E + L L G L T Sbjct: 65 ETIGKIKHRNLVPLLGYCKVG--DERL---LVYEFMKYGSLEDVLHDPKKAGVKLNWSTR 119 Query: 118 KDLMRQFLRGLDFLHANC---IVHRDLKPENILVTSGGTVKLADFGLARIYS---YQMAL 171 + + RGL FLH NC I+HRD+K N+L+ +++DFG+AR+ S +++ Sbjct: 120 RKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSV 179 Query: 172 TPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRK 211 + + T Y PE +T D++S G + E+ K Sbjct: 180 STLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGK 219 >5N23-A nrPDB Length = 352 Score = 67.0 bits (162), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 39/108 (36%), Positives = 61/108 (56%), Gaps = 5/108 (4%) Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 Q + ++LH+ +++RDLKPEN+L+ G +K+ADFG A+ + T + T Y A Sbjct: 150 QIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPWT-LCGTPEYLA 208 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLI 230 PE++L Y VD W++G + EM P F ADQ +I++ I Sbjct: 209 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF----ADQPIQIYEKI 252 >4LRM-A nrPDB Length = 334 Score = 67.0 bits (162), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 58/225 (25%), Positives = 103/225 (45%), Gaps = 27/225 (12%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFV----ALKSVRVPNGGGGGGGLPISTVRE 56 + + ++ + +G GA+GTVYK G V A+K +R + + E Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEI----LDE 71 Query: 57 VALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAET 116 ++ ++ +P+V RL+ +C TS T + I + F + +R + D + ++ Sbjct: 72 AYVMASVDNPGNPHVCRLLGICLTS-TVQLITQLMPFGCLLDYVREHKD-----NIGSQY 125 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-------YSYQM 169 + + Q +G+++L +VHRDL N+LV + VK+ DFGLA++ Y + Sbjct: 126 LLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEG 185 Query: 170 ALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEM--FRRKP 212 P+ + A E +L Y D+WS G E+ F KP Sbjct: 186 GKVPIK----WMALESILHRIYTHQSDVWSYGVTVWELMTFGSKP 226 >5LPV-A nrPDB Length = 296 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 60/217 (27%), Positives = 99/217 (45%), Gaps = 19/217 (8%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVRE-VALL 60 AT+ + + IG G +G VYKA G VA+K + +G G RE +A + Sbjct: 15 ATNGFHNDSLIGSGGFGDVYKAI-LKDGSAVAIKKLIHVSGQGD---------REFMAEM 64 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 + +H N+V L+ C D + V ++ + + K L T + + Sbjct: 65 ETIGKIKHRNLVPLLGYCKVG--DERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKI 122 Query: 121 MRQFLRGLDFLHANC---IVHRDLKPENILVTSGGTVKLADFGLARIYS---YQMALTPV 174 RGL FLH NC I+HRD+K N+L+ +++DFG+AR+ S ++++ + Sbjct: 123 AIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVSTL 182 Query: 175 VVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRK 211 T Y PE +T D++S G + E+ K Sbjct: 183 AGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGK 219 >4JLC-A nrPDB Length = 657 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 60/207 (28%), Positives = 92/207 (44%), Gaps = 24/207 (11%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G GA V++ R +G A V+V N + + +RE +L++L H N+ Sbjct: 16 LGQGATANVFRGRHKKTGDLYA---VKVFNNISFLRPVDVQ-MREFEVLKKLN---HKNI 68 Query: 72 VRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDK-APPPGLPAETIKDLMRQFLRGLD 129 V+L + + T ++ L+ E L T L++ + GLP ++R + G++ Sbjct: 69 VKLFAIEEETTTRHKV---LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 125 Query: 130 FLHANCIVHRDLKPENILVTSG----GTVKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 L N IVHRD+KP NI+ G KL DFG AR + T Y P++ Sbjct: 126 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 185 Query: 186 L--------LQSTYATPVDMWSVGCIF 204 Q Y VD+WSVG F Sbjct: 186 YERAVLRKDHQKKYGATVDLWSVGVTF 212 >3KRL-A nrPDB Length = 335 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 59/216 (27%), Positives = 96/216 (44%), Gaps = 26/216 (12%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPN-GGGGGGGLPISTVREVALLRRLEAFEHPN 70 +G GA+G V +A G A+ V V + + E+ ++ L +H N Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG--QHEN 111 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGL---------PAETI--K 118 +V L+ C V ++ E+ DL +L + PPGL P E + + Sbjct: 112 IVNLLGACTHGGP-----VLVITEYCCYGDLLNFLRRKRPPGLEYSYNPSHNPEEQLSSR 166 Query: 119 DLMR---QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY---SYQMALT 172 DL+ Q +G+ FL + +HRD+ N+L+T+G K+ DFGLAR S + Sbjct: 167 DLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKG 226 Query: 173 PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 + + + APE + Y D+WS G + E+F Sbjct: 227 NARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIF 262 >5H2U-A nrPDB Length = 267 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 36/100 (36%), Positives = 52/100 (52%), Gaps = 1/100 (1%) Query: 112 LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL 171 LP + D+ Q G+ +L + +HRDL NILV K+ DFGLAR+ + L Sbjct: 101 LPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYL 160 Query: 172 T-PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRR 210 + + + APE L + Y+T D+WS G + EMF R Sbjct: 161 SHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSR 200 >2QKW-B nrPDB Length = 321 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 61/215 (28%), Positives = 99/215 (46%), Gaps = 24/215 (11%) Query: 2 ATSRYEPVAEIGVGAYGTVYKA--RDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVAL 59 AT+ ++ IG G +G VYK RD G VALK R P G Sbjct: 37 ATNNFDHKFLIGHGVFGKVYKGVLRD---GAKVALKR-RTPESSQG-------IEEFETE 85 Query: 60 LRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYL--DKAPPPGLPAET 116 + L HP++V L+ C D ++ L++++++ +L+ +L P + E Sbjct: 86 IETLSFCRHPHLVSLIGFC-----DERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQ 140 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY--QMALTPV 174 ++ RGL +LH I+HRD+K NIL+ K+ DFG+++ + Q L+ V Sbjct: 141 RLEICIGAARGLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTV 200 Query: 175 VV-TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 V TL Y PE ++ D++S G + E+ Sbjct: 201 VKGTLGYIDPEYFIKGRLTEKSDVYSFGVVLFEVL 235 >6GQK-A nrPDB Length = 328 Score = 66.2 bits (160), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 62/219 (28%), Positives = 93/219 (42%), Gaps = 32/219 (14%) Query: 12 IGVGAYGTVYKAR-----DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF 66 +G GA+G V +A + VA+K ++ P+ ST RE AL+ L+ Sbjct: 49 LGAGAFGKVVEATAQGLIKSDAAMTVAVKMLK-PSAH--------STERE-ALMSELKVL 98 Query: 67 ----EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGL-PAETIKDLM 121 H N+V L+ C I + + LR D+ P + P + KD + Sbjct: 99 SYLGNHENIVNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPEDLYKDFL 158 Query: 122 R---------QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY---SYQM 169 Q +G+ FL + +HRDL NIL+T G K+ DFGLAR S + Sbjct: 159 TLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLARDIKNDSNYV 218 Query: 170 ALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 + + + APE + S Y D+WS G E+F Sbjct: 219 DKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELF 257 >6NPU-A nrPDB Length = 298 Score = 66.2 bits (160), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 53/205 (25%), Positives = 97/205 (47%), Gaps = 27/205 (13%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPIST-VREVALLRRLEAFEHP 69 ++G G YG VY+ VA+K+++ + + ++E A+++ ++ HP Sbjct: 33 KLGGGQYGEVYEGVWKKYSLTVAVKTLKEDT-------MEVEEFLKEAAVMKEIK---HP 82 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 N+V+L+ VC RE ++ E + +L YL + + A + + Q + Sbjct: 83 NLVQLLGVCT-----REPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAM 137 Query: 129 DFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS------YQMALTPVVVTLWYRA 182 ++L +HRDL N LV VK+ADFGL+R+ + + A P+ T A Sbjct: 138 EYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWT----A 193 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEM 207 PE L + ++ D+W+ G + E+ Sbjct: 194 PESLAYNKFSIKSDVWAFGVLLWEI 218 >6BDL-A nrPDB Length = 347 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 31/87 (35%), Positives = 46/87 (52%) Query: 130 FLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQS 189 +LH+ I++RDLKPEN+++ G KL DFG A+ + T Y APE++L Sbjct: 150 YLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNK 209 Query: 190 TYATPVDMWSVGCIFAEMFRRKPLFCG 216 + D WS+G + E+ P F G Sbjct: 210 GHDISADYWSLGILMYELLTGSPPFSG 236 >2VWV-A nrPDB Length = 302 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 63/240 (26%), Positives = 99/240 (41%), Gaps = 26/240 (10%) Query: 12 IGVGAYGTVYKARDPHSGH---FVALKSVRVPNGGGGGGGLPISTVRE-VALLRRLEAFE 67 IG G +G V + R G VA+K+++ GG RE ++ + FE Sbjct: 24 IGAGEFGEVCRGRLKAPGKKESCVAIKTLK--------GGYTERQRREFLSEASIMGQFE 75 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 HPN++RL V S + V ++ E ++ + + ++R G Sbjct: 76 HPNIIRLEGVVTNS-----MPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASG 130 Query: 128 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLW------YR 181 + +L VHRDL NILV S K++DFGL+R + +L + Sbjct: 131 MRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIPIRWT 190 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEM--FRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 APE + + + D WS G + E+ F +P + S D + I LPP D P Sbjct: 191 APEAIAFRKFTSASDAWSYGIVMWEVMSFGERP-YWDMSNQDVINAIEQDYRLPPPPDCP 249 >4EUU-A nrPDB Length = 319 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/211 (27%), Positives = 89/211 (42%), Gaps = 32/211 (15%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR----LEAFE 67 +G GA V++ R +G A+K IS +R V + R L+ Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFN-----------NISFLRPVDVQMREFEVLKKLN 65 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDK-APPPGLPAETIKDLMRQFL 125 H N+V+L + + T ++ L+ E L T L++ + GLP ++R + Sbjct: 66 HKNIVKLFAIEEETTTRHKV---LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 122 Query: 126 RGLDFLHANCIVHRDLKPENILVTSG----GTVKLADFGLARIYSYQMALTPVVVTLWYR 181 G++ L N IVHR++KP NI+ G KL DFG AR + T Y Sbjct: 123 GGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL 182 Query: 182 APEVL--------LQSTYATPVDMWSVGCIF 204 P++ Q Y VD+WS+G F Sbjct: 183 HPDMYERAVLRKDHQKKYGATVDLWSIGVTF 213 >4XEY-B nrPDB Length = 408 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 51/201 (25%), Positives = 95/201 (47%), Gaps = 19/201 (9%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPIST-VREVALLRRLEAFEHP 69 ++G G YG VY+ VA+K+++ + + ++E A+++ ++ HP Sbjct: 132 KLGGGQYGEVYEGVWKKYSLTVAVKTLKEDT-------MEVEEFLKEAAVMKEIK---HP 181 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 N+V+L+ VC RE ++ E + +L YL + + A + + Q + Sbjct: 182 NLVQLLGVCT-----REPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAM 236 Query: 129 DFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS--YQMALTPVVVTLWYRAPEVL 186 ++L +HRDL N LV VK+ADFGL+R+ + A + + APE L Sbjct: 237 EYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 296 Query: 187 LQSTYATPVDMWSVGCIFAEM 207 + ++ D+W+ G + E+ Sbjct: 297 AYNKFSIKSDVWAFGVLLWEI 317 >3HNG-A nrPDB Length = 360 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 37/99 (37%), Positives = 55/99 (55%), Gaps = 6/99 (6%) Query: 116 TIKDLMR---QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYSY--QM 169 T++DL+ Q RG++FL + +HRDL NIL++ VK+ DFGLAR IY + Sbjct: 197 TMEDLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYV 256 Query: 170 ALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 + L + APE + Y+T D+WS G + E+F Sbjct: 257 RKGDTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIF 295 >2DQ7-X nrPDB Length = 283 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 55/209 (26%), Positives = 97/209 (46%), Gaps = 27/209 (12%) Query: 9 VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 + +G G +G V+ + VA+K+++ G P S + E ++++L+ H Sbjct: 14 IKRLGNGQFGEVWMG-TWNGNTKVAIKTLK------PGTMSPESFLEEAQIMKKLK---H 63 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 +V+L V + E + +V E++++ L +L L + D+ Q G Sbjct: 64 DKLVQLYAVVS------EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAG 117 Query: 128 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY------SYQMALTPVVVTLWYR 181 + ++ +HRDL+ NILV +G K+ADFGLAR+ + Q A P+ T Sbjct: 118 MAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWT---- 173 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEMFRR 210 APE L + D+WS G + E+ + Sbjct: 174 APEAALYGRFTIKSDVWSFGILLTELVTK 202 >4AT3-A nrPDB Length = 299 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 57/218 (26%), Positives = 96/218 (44%), Gaps = 33/218 (15%) Query: 11 EIGVGAYGTVYKARD-----PHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 E+G GA+G V+ A VA+K+++ + RE LL L+ Sbjct: 20 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK-----DFHREAELLTNLQ- 73 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYL-----------DKAPPPGLP 113 H ++V+ VC + +VFE++ DL +L + PP L Sbjct: 74 --HEHIVKFYGVCVEGDP-----LIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELT 126 Query: 114 AETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYS--YQMA 170 + + +Q G+ +L + VHRDL N LV VK+ DFG++R +YS Y Sbjct: 127 QSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRV 186 Query: 171 LTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 ++ + + PE ++ + T D+WS+G + E+F Sbjct: 187 GGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIF 224 >3LZB-A nrPDB Length = 327 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/225 (25%), Positives = 102/225 (45%), Gaps = 30/225 (13%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFV----ALKSVRVPNGGGGGGGLPISTVRE 56 + + ++ + +G GA+GTVYK G V A+K +R P + Sbjct: 12 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATS-------PKANKEI 64 Query: 57 VALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAET 116 + + + ++P+V RL+ +C TS T + I + F + +R + D + ++ Sbjct: 65 LDEAYVMASVDNPHVCRLLGICLTS-TVQLITQLMPFGCLLDYVREHKD-----NIGSQY 118 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-------YSYQM 169 + + Q +G+++L +VHRDL N+LV + VK+ DFGLA++ Y + Sbjct: 119 LLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEG 178 Query: 170 ALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEM--FRRKP 212 P+ + A E +L Y D+WS G E+ F KP Sbjct: 179 GKVPIK----WMALESILHRIYTHQSDVWSYGVTVWELMTFGSKP 219 >5GNK-A nrPDB Length = 297 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/225 (25%), Positives = 102/225 (45%), Gaps = 30/225 (13%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFV----ALKSVRVPNGGGGGGGLPISTVRE 56 + + ++ + +G GA+GTVYK G V A+K +R P + Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATS-------PKANKEI 68 Query: 57 VALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAET 116 + + + ++P+V RL+ +C TS T + I + F + +R + D + ++ Sbjct: 69 LDEAYVMASVDNPHVCRLLGICLTS-TVQLIMQLMPFGCLLDYVREHKD-----NIGSQY 122 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-------YSYQM 169 + + Q +G+++L +VHRDL N+LV + VK+ DFGLA++ Y + Sbjct: 123 LLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEG 182 Query: 170 ALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEM--FRRKP 212 P+ + A E +L Y D+WS G E+ F KP Sbjct: 183 GKVPIK----WMALESILHRIYTHQSDVWSYGVTVWELMTFGSKP 223 >3C1X-A nrPDB Length = 373 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 50/157 (31%), Positives = 78/157 (49%), Gaps = 17/157 (10%) Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYL-DKAPPPGLPAETIKDLM 121 ++ F HPNV+ L+ +C S + V +H DLR ++ ++ P T+KDL+ Sbjct: 144 MKDFSHPNVLSLLGICLRSE-GSPLVVLPYMKH--GDLRNFIRNETHNP-----TVKDLI 195 Query: 122 ---RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYSYQM----ALTP 173 Q +G+ FL + VHRDL N ++ TVK+ADFGLAR +Y + T Sbjct: 196 GFGLQVAKGMKFLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTG 255 Query: 174 VVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRR 210 + + + A E L + T D+WS G + E+ R Sbjct: 256 AKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTR 292 >4EUT-A nrPDB Length = 396 Score = 65.5 bits (158), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 58/211 (27%), Positives = 89/211 (42%), Gaps = 32/211 (15%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR----LEAFE 67 +G GA V++ R +G A+K IS +R V + R L+ Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFN-----------NISFLRPVDVQMREFEVLKKLN 65 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDK-APPPGLPAETIKDLMRQFL 125 H N+V+L + + T ++ L+ E L T L++ + GLP ++R + Sbjct: 66 HKNIVKLFAIEEETTTRHKV---LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV 122 Query: 126 RGLDFLHANCIVHRDLKPENILVTSG----GTVKLADFGLARIYSYQMALTPVVVTLWYR 181 G++ L N IVHR++KP NI+ G KL DFG AR + T Y Sbjct: 123 GGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL 182 Query: 182 APEVL--------LQSTYATPVDMWSVGCIF 204 P++ Q Y VD+WS+G F Sbjct: 183 HPDMYERAVLRKDHQKKYGATVDLWSIGVTF 213 >2JDO-A nrPDB Length = 342 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 63/238 (26%), Positives = 104/238 (43%), Gaps = 27/238 (11%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL----RRLEAFE 67 +G G +G V R+ +G + A+K +R I EVA R L+ Sbjct: 18 LGKGTFGKVILVREKATGRYYAMKILRKE---------VIIAKDEVAHTVTESRVLQNTR 68 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 HP + L T ++ V E+ + + + E + + + Sbjct: 69 HPFLTALKYAFQTHD-----RLCFVMEYANGG-ELFFHLSRERVFTEERARFYGAEIVSA 122 Query: 128 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-YSYQMALTPVVVTLWYRAPEVL 186 L++LH+ +V+RD+K EN+++ G +K+ DFGL + S + T Y APEVL Sbjct: 123 LEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVL 182 Query: 187 LQSTYATPVDMWSVGCIFAEMF-RRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 + Y VD W +G + EM R P + + E ++F+LI L E +PR +S Sbjct: 183 EDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE-----RLFELI-LMEEIRFPRTLS 234 >5AMN-A nrPDB Length = 299 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 61/209 (29%), Positives = 94/209 (44%), Gaps = 21/209 (10%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G G +G V KA H +V V P ++ L+ HP+V Sbjct: 31 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENAS--PSELRDLLSEFNVLKQVNHPHV 88 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPP--PGLPAE---TIKDLMR--- 122 ++L C+ ++ + L+ E+ LR +L ++ PG P E T+ DL+ Sbjct: 89 IKLYGACS-----QDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALTMGDLISFAW 143 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IY---SYQMALTPVVVTL 178 Q +G+ +L +VHRDL NILV G +K++DFGL+R +Y SY + Sbjct: 144 QISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVK 203 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEM 207 W A E L Y T D+WS G + E+ Sbjct: 204 WM-AIESLFDHIYTTQSDVWSFGVLLWEI 231 >2XYN-A nrPDB Length = 292 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 54/205 (26%), Positives = 97/205 (47%), Gaps = 27/205 (13%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPIST-VREVALLRRLEAFEHP 69 ++G G YG VY VA+K+++ + + ++E A+++ ++ HP Sbjct: 39 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDT-------MEVEEFLKEAAVMKEIK---HP 88 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 N+V+L+ VC E +V E++ +L YL + + A + + Q + Sbjct: 89 NLVQLLGVCTL-----EPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 143 Query: 129 DFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS------YQMALTPVVVTLWYRA 182 ++L +HRDL N LV VK+ADFGL+R+ + + A P+ T A Sbjct: 144 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWT----A 199 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEM 207 PE L +T++ D+W+ G + E+ Sbjct: 200 PESLAYNTFSIKSDVWAFGVLLWEI 224 >4RT7-A nrPDB Length = 415 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 39/102 (38%), Positives = 54/102 (52%), Gaps = 12/102 (11%) Query: 116 TIKDLM---RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALT 172 T +DL+ Q +G++FL VHRDL N+LVT G VK+ DFGLAR M+ + Sbjct: 241 TFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDI---MSDS 297 Query: 173 PVVVT------LWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 VV + + APE L + Y D+WS G + E+F Sbjct: 298 NYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIF 339 >4YHJ-A nrPDB Length = 584 Score = 65.1 bits (157), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 37/111 (33%), Positives = 55/111 (49%) Query: 99 DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLAD 158 DL+ ++ PG + + GL+ L IV+RDLKPENIL+ G ++++D Sbjct: 271 DLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISD 330 Query: 159 FGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR 209 GLA + V T+ Y APEV+ Y D W +GC+ EM + Sbjct: 331 LGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKYTFSPDWWGLGCLIYEMIQ 381 >2FO0-A nrPDB Length = 495 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 50/201 (24%), Positives = 95/201 (47%), Gaps = 19/201 (9%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPIST-VREVALLRRLEAFEHP 69 ++G G YG VY+ VA+K+++ + + ++E A+++ ++ HP Sbjct: 224 KLGGGQYGEVYEGVWKKYSLTVAVKTLKEDT-------MEVEEFLKEAAVMKEIK---HP 273 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 N+V+L+ VC RE ++ E + +L YL + + A + + Q + Sbjct: 274 NLVQLLGVCT-----REPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAM 328 Query: 129 DFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS--YQMALTPVVVTLWYRAPEVL 186 ++L +HR+L N LV VK+ADFGL+R+ + A + + APE L Sbjct: 329 EYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESL 388 Query: 187 LQSTYATPVDMWSVGCIFAEM 207 + ++ D+W+ G + E+ Sbjct: 389 AYNKFSIKSDVWAFGVLLWEI 409 >3PVW-A nrPDB Length = 695 Score = 64.7 bits (156), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 57/204 (27%), Positives = 98/204 (48%), Gaps = 20/204 (9%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSV---RVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 IG G +G VY R +G A+K + R+ G L E +L + + Sbjct: 197 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLAL-----NERIMLSLVSTGDC 251 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAET-IKDLMRQFLR 126 P +V C + K++ + + ++ DL +L + G+ +E ++ + + Sbjct: 252 PFIV-----CMSYAFHTPDKLSFILDLMNGGDLHYHLSQH---GVFSEADMRFYAAEIIL 303 Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVL 186 GL+ +H +V+RDLKP NIL+ G V+++D GLA +S + V T Y APEVL Sbjct: 304 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-VGTHGYMAPEVL 362 Query: 187 LQS-TYATPVDMWSVGCIFAEMFR 209 + Y + D +S+GC+ ++ R Sbjct: 363 QKGVAYDSSADWFSLGCMLFKLLR 386 >5HIE-A nrPDB Length = 302 Score = 64.7 bits (156), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 38/117 (32%), Positives = 64/117 (54%), Gaps = 8/117 (6%) Query: 115 ETIK--DLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI---YSYQM 169 E IK D+ RQ +G+D+LHA I+HRDLK NI + TVK+ DFGLA + +S Sbjct: 125 EMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSH 184 Query: 170 ALTPVVVTLWYRAPEVLL---QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQL 223 + ++ + APEV+ ++ Y+ D+++ G + E+ + + + DQ+ Sbjct: 185 QFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQI 241 >6NT9-A nrPDB Length = 742 Score = 64.7 bits (156), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 58/207 (28%), Positives = 92/207 (44%), Gaps = 24/207 (11%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G GA V++ R +G A+K V N + + +RE +L++L H N+ Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIK---VFNNISFLRPVDVQ-MREFEVLKKLN---HKNI 67 Query: 72 VRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDK-APPPGLPAETIKDLMRQFLRGLD 129 V+L + + T ++ L+ E L T L++ + GLP ++R + G++ Sbjct: 68 VKLFAIEEETTTRHKV---LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 Query: 130 FLHANCIVHRDLKPENILVTSG----GTVKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 L N IVHR++KP NI+ G KL DFG AR + T Y P++ Sbjct: 125 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 Query: 186 L--------LQSTYATPVDMWSVGCIF 204 Q Y VD+WS+G F Sbjct: 185 YERAVLRKDHQKKYGATVDLWSIGVTF 211 >5UUU-A nrPDB Length = 547 Score = 64.7 bits (156), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 57/204 (27%), Positives = 98/204 (48%), Gaps = 20/204 (9%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSV---RVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 IG G +G VY R +G A+K + R+ G L E +L + + Sbjct: 206 IGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLAL-----NERIMLSLVSTGDC 260 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAET-IKDLMRQFLR 126 P +V C + K++ + + ++ DL +L + G+ +E ++ + + Sbjct: 261 PFIV-----CMSYAFHTPDKLSFILDLMNGGDLHYHLSQH---GVFSEADMRFYAAEIIL 312 Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVL 186 GL+ +H +V+RDLKP NIL+ G V+++D GLA +S + V T Y APEVL Sbjct: 313 GLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS-VGTHGYMAPEVL 371 Query: 187 LQS-TYATPVDMWSVGCIFAEMFR 209 + Y + D +S+GC+ ++ R Sbjct: 372 QKGVAYDSSADWFSLGCMLFKLLR 395 >3ALO-A nrPDB Length = 327 Score = 64.7 bits (156), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 71/240 (29%), Positives = 105/240 (43%), Gaps = 30/240 (12%) Query: 9 VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREV---ALLRRLEA 65 + EIG GAYG+V K SG +A+K +R STV E LL L+ Sbjct: 27 LGEIGRGAYGSVNKMVHKPSGQIMAVKRIR-------------STVDEKEQKQLLMDLDV 73 Query: 66 F----EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 + P +V+ D I + L+ D+ Y+ +P E + + Sbjct: 74 VMRSSDCPYIVQFYGA-LFREGDCWICMELMSTSFDK-FYKYVYSVLDDVIPEEILGKIT 131 Query: 122 RQFLRGLDFLHANC-IVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY 180 ++ L+ L N I+HRD+KP NIL+ G +KL DFG++ +A T Y Sbjct: 132 LATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPY 191 Query: 181 RAPEVLLQST----YATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPE 235 APE + S Y D+WS+G E+ R P NS DQL ++ + G PP+ Sbjct: 192 MAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQV--VKGDPPQ 249 >6O8B-A nrPDB Length = 665 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 58/207 (28%), Positives = 92/207 (44%), Gaps = 24/207 (11%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G GA V++ R +G A+K V N + + +RE +L++L H N+ Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIK---VFNNISFLRPVDVQ-MREFEVLKKLN---HKNI 75 Query: 72 VRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDK-APPPGLPAETIKDLMRQFLRGLD 129 V+L + + T ++ L+ E L T L++ + GLP ++R + G++ Sbjct: 76 VKLFAIEEETTTRHKV---LIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 132 Query: 130 FLHANCIVHRDLKPENILVTSG----GTVKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 L N IVHR++KP NI+ G KL DFG AR + T Y P++ Sbjct: 133 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDM 192 Query: 186 L--------LQSTYATPVDMWSVGCIF 204 Q Y VD+WS+G F Sbjct: 193 YERAVLRKDHQKKYGATVDLWSIGVTF 219 >5X3F-B nrPDB Length = 393 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 58/231 (25%), Positives = 108/231 (46%), Gaps = 27/231 (11%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR-L 63 +++ + +G G++G V + SG+ A+K + + + + +R L Sbjct: 85 QFDRIKTLGTGSFGRVMLVKHKESGNHYAMKIL------DKQKVVKLKQIEHTLNEKRIL 138 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMR 122 +A P +V+L S D + +V E+V ++ ++L + P Sbjct: 139 QAVNFPFLVKL----EFSFKDNS-NLYMVMEYVAGGEMFSHLRRIGRFSEPHARF--YAA 191 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY---SYQMALTPVVVTLW 179 Q + ++LH+ +++RDLKPEN+L+ G +++ DFG A+ ++ + TP Sbjct: 192 QIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPE----- 246 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLI 230 Y APE++L Y VD W++G + EM P F ADQ +I++ I Sbjct: 247 YLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF----ADQPIQIYEKI 293 >5HLW-A nrPDB Length = 299 Score = 64.3 bits (155), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 21/159 (13%) Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYL-DKAPPPGLPAETIKDL 120 ++ F HPNV+ L+ +C S E +V ++ DLR ++ ++ P T+KDL Sbjct: 75 MKDFSHPNVLSLLGICLRS----EGSPLVVLPYMKHGDLRNFIRNETHNP-----TVKDL 125 Query: 121 M---RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR------IYSYQMAL 171 + Q +G+ +L + VHRDL N ++ TVK+ADFGLAR YS Sbjct: 126 IGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKT 185 Query: 172 TPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRR 210 + W A E L + T D+WS G + E+ R Sbjct: 186 GAKLPVKW-MALESLQTQKFTTKSDVWSFGVLLWELMTR 223 >4WB7-A nrPDB Length = 405 Score = 64.3 bits (155), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 37/111 (33%), Positives = 61/111 (54%), Gaps = 12/111 (10%) Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY---SYQMALTPVVVTLW 179 Q + ++LH+ +++RDLKPEN+L+ G +++ DFG A+ ++ + TP Sbjct: 204 QIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPE----- 258 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLI 230 Y APE++L Y VD W++G + EM P F ADQ +I++ I Sbjct: 259 YLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF----ADQPIQIYEKI 305 >4P5Q-A nrPDB Length = 361 Score = 63.9 bits (154), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 50/185 (27%), Positives = 87/185 (47%), Gaps = 22/185 (11%) Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQF 124 F+HPN++RL V S+ V +V E+++ L ++L K + + ++R Sbjct: 91 FDHPNIIRLEGVVTKSK-----PVMIVTEYMENGSLDSFLRKHDAQFTVIQLV-GMLRGI 144 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI--------YSYQMALTPVVV 176 G+ +L VHRDL NIL+ S K++DFGL+R+ Y+ + P+ Sbjct: 145 ASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRW 204 Query: 177 TLWYRAPEVLLQSTYATPVDMWSVGCIFAEM--FRRKPLFCGNSEADQLGKIFDLIGLPP 234 T +PE + + + D+WS G + E+ + +P + S D + + + LPP Sbjct: 205 T----SPEAIAYRKFTSASDVWSYGIVLWEVMSYGERP-YWEMSNQDVIKAVDEGYRLPP 259 Query: 235 EDDWP 239 D P Sbjct: 260 PMDCP 264 >3BBT-B nrPDB Length = 328 Score = 63.9 bits (154), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 56/215 (26%), Positives = 91/215 (42%), Gaps = 36/215 (16%) Query: 9 VAEIGVGAYGTVYKARDPHSGHFVALK-SVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 V +G GA+GTVYK G V + ++++ N G P + V + + + + Sbjct: 20 VKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTG----PKANVEFMDEALIMASMD 75 Query: 68 HPNVVRLMDVC-------ATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 HP++VRL+ VC T + V EH D + ++ + + Sbjct: 76 HPHLVRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKD-------------NIGSQLLLNW 122 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-------YSYQMALTP 173 Q +G+ +L +VHRDL N+LV S VK+ DFGLAR+ Y+ P Sbjct: 123 CVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMP 182 Query: 174 VVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 + + A E + + D+WS G E+ Sbjct: 183 IK----WMALECIHYRKFTHQSDVWSYGVTIWELM 213 >3V5Q-A nrPDB Length = 297 Score = 63.9 bits (154), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 62/229 (27%), Positives = 98/229 (42%), Gaps = 38/229 (16%) Query: 11 EIGVGAYGTV-----YKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 E+G GA+G V Y VA+K+++ P RE LL L+ Sbjct: 22 ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARK-----DFQREAELLTNLQ- 75 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPP------GLPAETIK 118 H ++V+ VC + +VFE++ DL +L P G P + Sbjct: 76 --HEHIVKFYGVCGDGDP-----LIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKG 128 Query: 119 DL--------MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYS--Y 167 +L Q G+ +L + VHRDL N LV + VK+ DFG++R +YS Y Sbjct: 129 ELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDY 188 Query: 168 QMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR--RKPLF 214 ++ + + PE ++ + T D+WS G I E+F ++P F Sbjct: 189 YRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWF 237 >3SXS-A nrPDB Length = 268 Score = 63.5 bits (153), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 49/202 (24%), Positives = 89/202 (44%), Gaps = 17/202 (8%) Query: 9 VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 + E+G G +G V K + VA+K ++ G +E + +L H Sbjct: 13 LKELGSGQFGVV-KLGKWKGQYDVAVKMIK------EGSMSEDEFFQEAQTMMKLS---H 62 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 P +V+ VC+ +E + +V E++ ++ GL + ++ G+ Sbjct: 63 PKLVKFYGVCS-----KEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGM 117 Query: 129 DFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVT--LWYRAPEVL 186 FL ++ +HRDL N LV VK++DFG+ R ++ V + + APEV Sbjct: 118 AFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVF 177 Query: 187 LQSTYATPVDMWSVGCIFAEMF 208 Y++ D+W+ G + E+F Sbjct: 178 HYFKYSSKSDVWAFGILMWEVF 199 >2PMN-X nrPDB Length = 348 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 60/220 (27%), Positives = 99/220 (45%), Gaps = 22/220 (10%) Query: 88 KVTLVFEHVDQD----LRTY---LDKAPPPGLPAETIKDLMRQFLRGLDFLH-ANCIVHR 139 +V +++E+++ D Y LDK +P + IK +++ L ++H I HR Sbjct: 117 EVYIIYEYMENDSILKFDEYFFVLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHR 176 Query: 140 DLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLL-QSTY-ATPVDM 197 D+KP NIL+ G VKL+DFG + Y + T + PE +S+Y VD+ Sbjct: 177 DVKPSNILMDKNGRVKLSDFGESE-YMVDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDI 235 Query: 198 WSVG-CIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAF-PPRGPR 255 WS+G C++ + P S L ++F+ I ++P L R F P + Sbjct: 236 WSLGICLYVMFYNVVPF----SLKISLVELFNNIR-TKNIEYP----LDRNHFLYPLTNK 286 Query: 256 PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 + L L NP +RI++ AL+H +L Sbjct: 287 KSTCSNNFLSNEDIDFLKLFLRKNPAERITSEDALKHEWL 326 >5U6B-A nrPDB Length = 307 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 45/158 (28%), Positives = 74/158 (46%), Gaps = 11/158 (6%) Query: 63 LEAFEHPNVVRLMDVC--ATSRTDREIKVTLVFEHVDQDLRTYLDKA----PPPGLPAET 116 ++ F+HPNV+RL+ VC + R V ++ DL ++L + P LP + Sbjct: 78 MKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQM 137 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLA-RIYS---YQMALT 172 + M G+++L +HRDL N ++ +V +ADFGL+ +IY+ Y+ Sbjct: 138 LVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRI 197 Query: 173 PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRR 210 + W A E L Y + D+WS G E+ R Sbjct: 198 AKMPVKWI-AIESLADRVYTSKSDVWSFGVTMWEIATR 234 >4XI2-A nrPDB Length = 446 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 50/204 (24%), Positives = 91/204 (44%), Gaps = 21/204 (10%) Query: 9 VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 + E+G G +G V K + VA+K +R G + E ++ L H Sbjct: 192 LKELGTGQFGVV-KYGKWRGQYDVAIKMIR------EGSMSEDEFIEEAKVMMNLS---H 241 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLMRQFLRG 127 +V+L VC R + ++ E++ L YL + + + ++ + Sbjct: 242 EKLVQLYGVCTKQRP-----IFIITEYMANGCLLNYL-REMRHRFQTQQLLEMCKDVCEA 295 Query: 128 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY---SYQMALTPVVVTLWYRAPE 184 +++L + +HRDL N LV G VK++DFGL+R Y ++ W PE Sbjct: 296 MEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRW-SPPE 354 Query: 185 VLLQSTYATPVDMWSVGCIFAEMF 208 VL+ S +++ D+W+ G + E++ Sbjct: 355 VLMYSKFSSKSDIWAFGVLMWEIY 378 >3PPZ-A nrPDB Length = 309 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 61/202 (30%), Positives = 97/202 (48%), Gaps = 18/202 (8%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +IG G++GTV++A G VA+K + + +REVA+++RL HPN Sbjct: 44 KIGAGSFGTVHRAE--WHGSDVAVKILMEQDFHAERVN---EFLREVAIMKRLR---HPN 95 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKA-PPPGLPAETIKDLMRQFLRGL 128 +V M + +++V E++ + L L K+ L + +G+ Sbjct: 96 IVLFMGAVT-----QPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVAKGM 150 Query: 129 DFLHANC--IVHRDLKPENILVTSGGTVKLADFGLARIY-SYQMALTPVVVTLWYRAPEV 185 ++LH IVHRDLK N+LV TVK+ DFGL+R+ S ++ T + APEV Sbjct: 151 NYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEV 210 Query: 186 LLQSTYATPVDMWSVGCIFAEM 207 L D++S G I E+ Sbjct: 211 LRDEPSNEKSDVYSFGVILWEL 232 >2I0E-A nrPDB Length = 353 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 1/103 (0%) Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLWYRAPEV 185 GL FL + I++RDLK +N+++ S G +K+ADFG+ + + T T Y APE+ Sbjct: 133 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 192 Query: 186 LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD 228 + Y VD W+ G + EM + F G E + I + Sbjct: 193 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 235 >3PFQ-A nrPDB Length = 674 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 34/103 (33%), Positives = 53/103 (51%), Gaps = 1/103 (0%) Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLWYRAPEV 185 GL FL + I++RDLK +N+++ S G +K+ADFG+ + + T T Y APE+ Sbjct: 454 GLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 513 Query: 186 LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD 228 + Y VD W+ G + EM + F G E + I + Sbjct: 514 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME 556 >5DBX-A nrPDB Length = 328 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 38/103 (36%), Positives = 55/103 (53%), Gaps = 7/103 (6%) Query: 112 LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL 171 L I ++++ L GLD+LH N +HRDLK NIL+ G+V++ADFG++ + + Sbjct: 114 LEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDV 173 Query: 172 T------PVVVTLWYRAPEVLLQ-STYATPVDMWSVGCIFAEM 207 T V T + APEV+ Q Y DMWS G E+ Sbjct: 174 TRNKVRKDFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIEL 216 >3A8W-A nrPDB Length = 345 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 56/198 (28%), Positives = 88/198 (44%), Gaps = 13/198 (6%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 IG G+Y V R + A+K V+ + T + V +A HP + Sbjct: 17 IGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFE----QASNHPFL 72 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 V L T E ++ V E+V+ DL ++ + LP E + + L++ Sbjct: 73 VGLHSCFQT-----ESRLFFVIEYVNGGDLMFHMQRQRK--LPEEHARFYSAEISLALNY 125 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLWYRAPEVLLQS 189 LH I++RDLK +N+L+ S G +KL D+G+ + T T Y APE+L Sbjct: 126 LHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGE 185 Query: 190 TYATPVDMWSVGCIFAEM 207 Y VD W++G + EM Sbjct: 186 DYGFSVDWWALGVLMFEM 203 >6FEX-A nrPDB Length = 321 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 52/169 (30%), Positives = 82/169 (48%), Gaps = 21/169 (12%) Query: 54 VREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYL------DKA 107 ++EV ++ RL+ PN++RL+ VC + D +T E + DL +L DKA Sbjct: 78 LKEVKIMSRLK---DPNIIRLLGVCV--QDDPLCMITDYME--NGDLNQFLSAHQLEDKA 130 Query: 108 P--PPGLPAETIKDLMR---QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLA 162 PG P + L+ Q G+ +L VHRDL N LV T+K+ADFG++ Sbjct: 131 AEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMS 190 Query: 163 R-IYS--YQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 R +Y+ Y V+ + + A E +L + T D+W+ G E+ Sbjct: 191 RNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVL 239 >3DAK-A nrPDB Length = 290 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 37/103 (35%), Positives = 56/103 (54%), Gaps = 7/103 (6%) Query: 112 LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL 171 L TI ++R+ L GL++LH N +HRD+K NIL+ G+V++ADFG++ + + Sbjct: 113 LDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDI 172 Query: 172 T------PVVVTLWYRAPEVLLQ-STYATPVDMWSVGCIFAEM 207 T V T + APEV+ Q Y D+WS G E+ Sbjct: 173 TRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIEL 215 >1FVR-A nrPDB Length = 327 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 63/231 (27%), Positives = 96/231 (41%), Gaps = 25/231 (10%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 IG G +G V KAR G + R+ + E+ +L +L HPN+ Sbjct: 33 IGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAG--ELEVLCKLG--HHPNI 88 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKA------PPPGLPAETIKDLMRQF 124 + L+ C + + L E+ +L +L K+ P + T L Q Sbjct: 89 INLLGAC-----EHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQ 143 Query: 125 L--------RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV 176 L RG+D+L +HRDL NILV K+ADFGL+R + T + Sbjct: 144 LLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRL 203 Query: 177 TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPL-FCGNSEADQLGKI 226 + + A E L S Y T D+WS G + E+ +CG + A+ K+ Sbjct: 204 PVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKL 254 >2OGV-A nrPDB Length = 317 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 55/210 (26%), Positives = 92/210 (43%), Gaps = 20/210 (9%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPN-GGGGGGGLPISTVREVALLRRLEAFEHPN 70 +G GA+G V +A G A+ V V + + E+ ++ L +H N Sbjct: 46 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG--QHEN 103 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAE-----TIKDLMR-- 122 +V L+ C V ++ E+ DL +L + L E ++DL+ Sbjct: 104 IVNLLGACTHGGP-----VLVITEYCCYGDLLNFLRRKAEADLDKEDGRPLELRDLLHFS 158 Query: 123 -QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY---SYQMALTPVVVTL 178 Q +G+ FL + +HRD+ N+L+T+G K+ DFGLAR S + + + Sbjct: 159 SQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPV 218 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 + APE + Y D+WS G + E+F Sbjct: 219 KWMAPESIFDCVYTVQSDVWSYGILLWEIF 248 >5HVK-A nrPDB Length = 315 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 53/234 (22%), Positives = 96/234 (41%), Gaps = 35/234 (14%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKS-VRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +G G +G K +G + +K +R + ++EV ++R EHPN Sbjct: 22 LGKGCFGQAIKVTHRETGEVMVMKELIRFDEE------TQRTFLKEVKVMR---CLEHPN 72 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 V++ + V + ++ + E++ + K+ P + G+ + Sbjct: 73 VLKFIGVLYKDK-----RLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAY 127 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL---------------TPVV 175 LH+ I+HR+L N LV V +ADFGLAR+ + VV Sbjct: 128 LHSMNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVV 187 Query: 176 VTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDL 229 ++ APE++ +Y VD++S G + E+ R N++ D L + D Sbjct: 188 GNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRV-----NADPDYLPRTMDF 236 >3CJF-A nrPDB Length = 309 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 61/217 (28%), Positives = 92/217 (42%), Gaps = 31/217 (14%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF----E 67 +G GA+G V +A ++V V G + AL+ L+ Sbjct: 35 LGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGA-----THSEHRALMSELKILIHIGH 89 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL-- 125 H NVV L+ C ++ + V + F +L TYL +P KDL + FL Sbjct: 90 HLNVVNLLGAC--TKPGGPLMVIVEFCKFG-NLSTYLRSKRNEFVP---YKDLYKDFLTL 143 Query: 126 -----------RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYS--YQMAL 171 +G++FL + +HRDL NIL++ VK+ DFGLAR IY + Sbjct: 144 EHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRK 203 Query: 172 TPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 + L + APE + Y D+WS G + E+F Sbjct: 204 GDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIF 240 >1BYG-A nrPDB Length = 278 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 50/198 (25%), Positives = 87/198 (43%), Gaps = 19/198 (9%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 IG G +G V + G+ VA+K ++ N L ++V + H N+ Sbjct: 29 IGKGEFGDVMLG--DYRGNKVAVKCIK--NDATAQAFLAEASV--------MTQLRHSNL 76 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 V+L+ V + + +V E++ + L YL L + + +++ Sbjct: 77 VQLLGVIVEEKGG----LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 132 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQST 190 L N VHRDL N+LV+ K++DFGL + S + V + APE L + Sbjct: 133 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK--WTAPEALREKK 190 Query: 191 YATPVDMWSVGCIFAEMF 208 ++T D+WS G + E++ Sbjct: 191 FSTKSDVWSFGILLWEIY 208 >5B2L-A nrPDB Length = 324 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 55/207 (26%), Positives = 92/207 (44%), Gaps = 18/207 (8%) Query: 7 EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF 66 E + E+G G G V+K R +GH +A+K +R G I +V L ++ Sbjct: 20 ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMR--RSGNKEENKRILMDLDVVL----KSH 73 Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLR 126 + P +V+ T+ TD I + L+ ++ L K +P + + ++ Sbjct: 74 DCPYIVQCFGTFITN-TDVFIAMELMGTSAEK-----LKKRMQGPIPERILGKMTVAIVK 127 Query: 127 GLDFL-HANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 L +L + ++HRD+KP NIL+ G +KL DFG++ A T Y APE Sbjct: 128 ALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPER 187 Query: 186 L-----LQSTYATPVDMWSVGCIFAEM 207 + + Y D+WS+G E+ Sbjct: 188 IDPPDPTKPDYDIRADVWSLGISLVEL 214 >4NEU-A nrPDB Length = 333 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 61/231 (26%), Positives = 98/231 (42%), Gaps = 37/231 (16%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 M +S + AE+ G +G V G + + PN L + E ++ Sbjct: 21 MKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL----LEEAKMM 76 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 RL H VV+L+ V E K +LV E++++ ++ KA P + Sbjct: 77 NRLR---HSRVVKLLGVII-----EEGKYSLVMEYMEKGNLMHVLKAEM-STPLSVKGRI 127 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM----------- 169 + + + G+ +LH ++H+DLKPENILV + +K+AD GLA S++M Sbjct: 128 ILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLA---SFKMWSKLNNEEHNE 184 Query: 170 ------ALTPVVVTLWYRAPEVLLQSTYATPV---DMWSVGCIFAEMFRRK 211 TL+Y APE L A P D++S + +F K Sbjct: 185 LREVDGTAKKNGGTLYYMAPE-HLNDVNAKPTEKSDVYSFAVVLWAIFANK 234 >5X5O-A nrPDB Length = 310 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 50/208 (24%), Positives = 91/208 (43%), Gaps = 26/208 (12%) Query: 13 GVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVV 72 G G++G+VY+A+ VA+K + L I E+ L H N++ Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKKL-----------LKIEKEAEI-----LSVLSHRNII 67 Query: 73 RLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFL 131 + V +V E+ L Y++ + + I +G+ +L Sbjct: 68 QFYGVILEPPN-----YGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYL 122 Query: 132 HANC---IVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQ 188 H ++HRDLK N+++ + G +K+ DFG +R +++ ++ +V T + APEV+ Sbjct: 123 HMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMS-LVGTFPWMAPEVIQS 181 Query: 189 STYATPVDMWSVGCIFAEMFRRKPLFCG 216 + D +S G + EM R+ F G Sbjct: 182 LPVSETCDTYSYGVVLWEMLTREVPFKG 209 >3MV5-A nrPDB Length = 342 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 43/121 (35%), Positives = 63/121 (52%), Gaps = 9/121 (7%) Query: 123 QFLRGLDFLHA-NCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLWY 180 + + LD+LH+ +V+RDLK EN+++ G +K+ DFGL + A T Y Sbjct: 118 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEY 177 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMF-RRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 APEVL + Y VD W +G + EM R P + + E K+F+LI L E +P Sbjct: 178 LAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE-----KLFELI-LMEEIRFP 231 Query: 240 R 240 R Sbjct: 232 R 232 >6E4F-A nrPDB Length = 290 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 50/204 (24%), Positives = 93/204 (45%), Gaps = 21/204 (10%) Query: 9 VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 + E+G G +G V K + VA+K ++ G + E ++ L H Sbjct: 36 LKELGTGQFGVV-KYGKWRGQYDVAIKMIK------EGSMSEDEFIEEAKVMMNLS---H 85 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLMRQFLRG 127 +V+L VC R + ++ E++ L YL + + + ++ + Sbjct: 86 EKLVQLYGVCTKQRP-----IFIITEYMANGCLLNYL-REMRHRFQTQQLLEMCKDVCEA 139 Query: 128 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLW---YRAPE 184 +++L + +HRDL N LV G VK++DFGL+R Y T V + + + PE Sbjct: 140 MEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSR-YVLDDEYTSSVGSKFPVRWSPPE 198 Query: 185 VLLQSTYATPVDMWSVGCIFAEMF 208 VL+ S +++ D+W+ G + E++ Sbjct: 199 VLMYSKFSSKSDIWAFGVLMWEIY 222 >4R7H-A nrPDB Length = 343 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 61/229 (26%), Positives = 97/229 (42%), Gaps = 45/229 (19%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTV---REVALLRRLEAF-- 66 +G GA+G V +A G A+ V V + ST + AL+ L+ Sbjct: 58 LGAGAFGKVVEATAFGLGKEDAVLKVAVK--------MLKSTAHADEKEALMSELKIMSH 109 Query: 67 --EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAP-------------PP 110 +H N+V L+ C V ++ E+ DL +L + P Sbjct: 110 LGQHENIVNLLGACTHGGP-----VLVITEYCTYGDLLNFLRRKAEAMLGPSLSPGQDPE 164 Query: 111 GLPAE-----TIKDLMR---QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLA 162 GL E ++DL+ Q +G+ FL + +HRD+ N+L+T+G K+ DFGLA Sbjct: 165 GLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLA 224 Query: 163 RIY---SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 R S + + + + APE + S Y D+WS G + E+F Sbjct: 225 RDIMNDSNYIVKGNARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEIF 273 >2Y6O-A nrPDB Length = 291 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 62/242 (25%), Positives = 107/242 (44%), Gaps = 32/242 (13%) Query: 12 IGVGAYGTVYKARDPHSGH---FVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 IGVG +G V R G VA+K+++ G + E +++ + F+H Sbjct: 22 IGVGEFGEVCSGRLKVPGKREICVAIKTLK----AGYTDKQRRDFLSEASIMGQ---FDH 74 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 PN++ L V + V ++ E+++ L +L K + + ++R G Sbjct: 75 PNIIHLEGVVTKCKP-----VMIITEYMENGSLDAFLRKNDGRFTVIQLV-GMLRGIGSG 128 Query: 128 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI--------YSYQMALTPVVVTLW 179 + +L VHRDL NILV S K++DFG++R+ Y+ + P+ T Sbjct: 129 MKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWT-- 186 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEM--FRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 APE + + + D+WS G + E+ + +P + S D + I + LPP D Sbjct: 187 --APEAIAYRKFTSASDVWSYGIVMWEVMSYGERP-YWDMSNQDVIKAIEEGYRLPPPMD 243 Query: 238 WP 239 P Sbjct: 244 CP 245 >3KUL-B nrPDB Length = 325 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 40/147 (27%), Positives = 68/147 (46%), Gaps = 9/147 (6%) Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 F+HPN++RL V R + + +D LRT+ + + ++R Sbjct: 107 FDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDTFLRTHDGQ-----FTIMQLVGMLRGVG 161 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS----YQMALTPVVVTLWYR 181 G+ +L VHRDL N+LV S K++DFGL+R+ T + + + Sbjct: 162 AGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTGGKIPIRWT 221 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEMF 208 APE + T+++ D+WS G + E+ Sbjct: 222 APEAIAFRTFSSASDVWSFGVVMWEVL 248 >5KCV-A nrPDB Length = 460 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 43/121 (35%), Positives = 63/121 (52%), Gaps = 9/121 (7%) Query: 123 QFLRGLDFLHA-NCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-TLWY 180 + + LD+LH+ +V+RDLK EN+++ G +K+ DFGL + A T Y Sbjct: 270 EIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEY 329 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMF-RRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 APEVL + Y VD W +G + EM R P + + E K+F+LI L E +P Sbjct: 330 LAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHE-----KLFELI-LMEEIRFP 383 Query: 240 R 240 R Sbjct: 384 R 384 >1K9A-A nrPDB Length = 450 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 50/198 (25%), Positives = 87/198 (43%), Gaps = 19/198 (9%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 IG G +G V + G+ VA+K ++ N L ++V + H N+ Sbjct: 201 IGKGEFGDVMLG--DYRGNKVAVKCIK--NDATAQAFLAEASV--------MTQLRHSNL 248 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 V+L+ V + + +V E++ + L YL L + + +++ Sbjct: 249 VQLLGVIVEEKGG----LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQST 190 L N VHRDL N+LV+ K++DFGL + S + V + APE L + Sbjct: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVK--WTAPEALREKK 362 Query: 191 YATPVDMWSVGCIFAEMF 208 ++T D+WS G + E++ Sbjct: 363 FSTKSDVWSFGILLWEIY 380 >3C51-A nrPDB Length = 543 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 33/86 (38%), Positives = 49/86 (56%), Gaps = 1/86 (1%) Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLA-RIYSYQMALTPVVVTLWYR 181 Q + GL+ LH I++RDLKPEN+L+ G V+++D GLA + + Q T + Sbjct: 297 QIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAGTPGFM 356 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEM 207 APE+LL Y VD +++G EM Sbjct: 357 APELLLGEEYDFSVDYFALGVTLYEM 382 >3ZBF-A nrPDB Length = 322 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 65/217 (29%), Positives = 99/217 (45%), Gaps = 32/217 (14%) Query: 12 IGVGAYGTVYKARDPH-----SGHF-VALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +G GA+G VY+ SG VA+K+++ G I ++E L+ + Sbjct: 41 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLK----KGSTDQEKIEFLKEAHLMSK--- 93 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAP-----PPGLPAETIKD 119 F HPN+++ + VC + ++ E ++ DL TYL KA P L + D Sbjct: 94 FNHPNILKQLGVCLLNEPQ-----YIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVD 148 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILV-----TSGGTVKLADFGLAR-IYS--YQMAL 171 L +G +L +HRDL N LV TS VK+ DFGLAR IY Y Sbjct: 149 LCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKR 208 Query: 172 TPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 ++ + + APE L+ + T D+WS G + E+ Sbjct: 209 GEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEIL 245 >2R2P-A nrPDB Length = 295 Score = 61.2 bits (147), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 95/208 (45%), Gaps = 29/208 (13%) Query: 12 IGVGAYGTVYKARDPHSGHF---VALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 IG G +G V R G VA+K+++V G + E +++ + F+H Sbjct: 30 IGAGEFGEVCSGRLKLPGKRELPVAIKTLKV----GYTEKQRRDFLGEASIMGQ---FDH 82 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 PN++ L V S+ V +V E+++ L T+L K + + ++R G Sbjct: 83 PNIIHLEGVVTKSKP-----VMIVTEYMENGSLDTFLKKNDGQFTVIQLV-GMLRGISAG 136 Query: 128 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI--------YSYQMALTPVVVTLW 179 + +L VHRDL NIL+ S K++DFGL+R+ Y+ + P+ T Sbjct: 137 MKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWT-- 194 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEM 207 APE + + + D+WS G + E+ Sbjct: 195 --APEAIAFRKFTSASDVWSYGIVMWEV 220 >6J5U-C nrPDB Length = 426 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 63/222 (28%), Positives = 95/222 (42%), Gaps = 28/222 (12%) Query: 2 ATSRYEPVAEIGVGAYGTVYK---------ARDPHSGHFVALKSVRVPNGGGGGGGLPIS 52 AT + +G G +G V+K A P SG VA+K ++ P G G Sbjct: 82 ATKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLK-PEGFQG----HKE 136 Query: 53 TVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPG 111 + EV L +L HPN+V L+ CA LV+E + + L +L + Sbjct: 137 WLTEVNYLGQLS---HPNLVLLVGYCAEGENR-----LLVYEFMPKGSLENHLFRRGAQP 188 Query: 112 LPAETIKDLMRQFLRGLDFLH--ANCIVHRDLKPENILVTSGGTVKLADFGLAR---IYS 166 L + +GL FLH + +++RD K NIL+ + KL+DFGLA+ Sbjct: 189 LTWAIRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGD 248 Query: 167 YQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 T V+ T Y APE + D++S G + E+ Sbjct: 249 NTHVSTKVIGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELI 290 >4Y93-A nrPDB Length = 446 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 45/203 (22%), Positives = 87/203 (42%), Gaps = 19/203 (9%) Query: 9 VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 + E+G G +G V K + VA+K ++ G + E ++ L H Sbjct: 193 LKELGTGQFGVV-KYGKWRGQYDVAIKMIK------EGSMSEDEFIEEAKVMMNLS---H 242 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 +V+L VC R + ++ E++ + + + ++ + + Sbjct: 243 EKLVQLYGVCTKQRP-----IFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAM 297 Query: 129 DFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY---SYQMALTPVVVTLWYRAPEV 185 ++L + +HRDL N LV G VK++DFG+ R Y + W +PEV Sbjct: 298 EYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKW-ASPEV 356 Query: 186 LLQSTYATPVDMWSVGCIFAEMF 208 L+ S +++ D+W+ G + E++ Sbjct: 357 LMYSKFSSKSDIWAFGVLMWEIY 379 >3AOX-A nrPDB Length = 344 Score = 61.2 bits (147), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 64/219 (29%), Positives = 99/219 (45%), Gaps = 39/219 (17%) Query: 12 IGVGAYGTVYKAR------DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +G GA+G VY+ + DP S VA+K+ LP + L +EA Sbjct: 55 LGHGAFGEVYEGQVSGMPNDP-SPLQVAVKT------------LPEVCSEQDELDFLMEA 101 Query: 66 -----FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYL-DKAPPPGLPAE-TIK 118 F H N+VR + V S R I + L+ DL+++L + P P P+ + Sbjct: 102 LIISKFNHQNIVRCIGVSLQS-LPRFILLELM---AGGDLKSFLRETRPRPSQPSSLAML 157 Query: 119 DLM---RQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLAR-IY--SYQM 169 DL+ R G +L N +HRD+ N L+T G K+ DFG+AR IY SY Sbjct: 158 DLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYR 217 Query: 170 ALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 ++ + + PE ++ + + D WS G + E+F Sbjct: 218 KGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIF 256 >3I81-A nrPDB Length = 315 Score = 60.8 bits (146), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 62/221 (28%), Positives = 96/221 (43%), Gaps = 43/221 (19%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR-------- 62 E+G G++G VY+ G RV I TV E A +R Sbjct: 25 ELGQGSFGMVYEG--VAKGVVKDEPETRVA----------IKTVNEAASMRERIEFLNEA 72 Query: 63 --LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ--DLRTYLDKAPP-----PGLP 113 ++ F +VVRL+ V + + TLV + DL++YL P P L Sbjct: 73 SVMKEFNCHHVVRLLGVVSQGQP------TLVIMELMTRGDLKSYLRSLRPEMENNPVLA 126 Query: 114 AETIKDLMR---QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYS--- 166 ++ +++ + G+ +L+AN VHRDL N +V TVK+ DFG+ R IY Sbjct: 127 PPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDY 186 Query: 167 YQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEM 207 Y+ ++ W +PE L + T D+WS G + E+ Sbjct: 187 YRKGGKGLLPVRWM-SPESLKDGVFTTYSDVWSFGVVLWEI 226 >1VZO-A nrPDB Length = 355 Score = 60.8 bits (146), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 60/259 (23%), Positives = 115/259 (44%), Gaps = 35/259 (13%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + +E + +G GAYG V+ VR +G G + +++ ++ Sbjct: 51 VGIENFELLKVLGTGAYGKVF--------------LVRKISGHDTGKLYAMKVLKKATIV 96 Query: 61 RRLEAFEHPNVVR-----------LMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAP 108 ++ + EH R L+ + +T E K+ L+ ++++ +L T+L + Sbjct: 97 QKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQT--ETKLHLILDYINGGELFTHLSQRE 154 Query: 109 PPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR--IYS 166 ++ + + + L+ LH I++RD+K ENIL+ S G V L DFGL++ + Sbjct: 155 R--FTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVAD 212 Query: 167 YQMALTPVVVTLWYRAPEVLL--QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLG 224 T+ Y AP+++ S + VD WS+G + E+ F + E + Sbjct: 213 ETERAYDFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQA 272 Query: 225 KIFDLIGLPPEDDWPRDVS 243 +I I L E +P+++S Sbjct: 273 EISRRI-LKSEPPYPQEMS 290 >1U59-A nrPDB Length = 287 Score = 60.8 bits (146), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 54/205 (26%), Positives = 91/205 (44%), Gaps = 25/205 (12%) Query: 11 EIGVGAYGTV----YKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF 66 E+G G +G+V Y+ R VA+K ++ G +RE ++ +L+ Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQID--VAIKVLK----QGTEKADTEEMMREAQIMHQLD-- 68 Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLMRQFL 125 +P +VRL+ VC + LV E L +L +P + +L+ Q Sbjct: 69 -NPYIVRLIGVCQAE------ALMLVMEMAGGGPLHKFL-VGKREEIPVSNVAELLHQVS 120 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALTPVVVTLWYR 181 G+ +L VHRDL N+L+ + K++DFGL++ SY A + L + Sbjct: 121 MGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWY 180 Query: 182 APEVLLQSTYATPVDMWSVGCIFAE 206 APE + +++ D+WS G E Sbjct: 181 APECINFRKFSSRSDVWSYGVTMWE 205 >3QD2-B nrPDB Length = 332 Score = 60.8 bits (146), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 72/294 (24%), Positives = 118/294 (40%), Gaps = 79/294 (26%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +EP+ +G G +G V++A++ A+K +R+PN + +REV L +L Sbjct: 8 FEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKV----MREVKALAKL-- 61 Query: 66 FEHPNVVRLMDVCATS---RTDREI-KVTLVFEHVDQDLRT---------YLDKAPP--- 109 EHP +VR + + + E+ ++ L E D L + + + P Sbjct: 62 -EHPGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFST 120 Query: 110 --------PGLP------------AETIKDLMRQFLRGLDFLHANC-------------- 135 P P E +KD M + D H C Sbjct: 121 KNTVGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFL 180 Query: 136 ----IVHRDLKPENILVTSGGTVKLADFGLARIYSY----QMALTPV---------VVTL 178 ++HRDLKP NI T VK+ DFGL Q LTP+ V T Sbjct: 181 HSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTK 240 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGL 232 Y +PE + + Y+ VD++S+G I E+ L+ +++ +++ I D+ L Sbjct: 241 LYMSPEQIHGNNYSHKVDIFSLGLILFEL-----LYSFSTQMERVRIITDVRNL 289 >1JPA-A nrPDB Length = 312 Score = 60.8 bits (146), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 61/240 (25%), Positives = 99/240 (41%), Gaps = 26/240 (10%) Query: 12 IGVGAYGTVYKARDPHSGH---FVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 IG G +G V G FVA+K+++ G + E +++ + F+H Sbjct: 41 IGAGEFGEVCSGHLKLPGKREIFVAIKTLK----SGYTEKQRRDFLSEASIMGQ---FDH 93 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 PNV+ L V S V ++ E ++ + + ++R G+ Sbjct: 94 PNVIHLEGVVTKS-----TPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGM 148 Query: 129 DFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-------SYQMALTPVVVTLWYR 181 +L VHRDL NILV S K++DFGL+R +Y AL + W Sbjct: 149 KYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRW-T 207 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEM--FRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 APE + + + D+WS G + E+ + +P + + D + I LPP D P Sbjct: 208 APEAIQYRKFTSASDVWSYGIVMWEVMSYGERP-YWDMTNQDVINAIEQDYRLPPPMDCP 266 >6BSD-A nrPDB Length = 876 Score = 60.8 bits (146), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 49/175 (28%), Positives = 81/175 (46%), Gaps = 27/175 (15%) Query: 54 VREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYL--------- 104 ++EV ++ RL+ PN++RL+ VC + D +T E + DL +L Sbjct: 633 LKEVKIMSRLK---DPNIIRLLGVCV--QDDPLCMITDYME--NGDLNQFLSAHQLEDKA 685 Query: 105 -DKAPPPGLPAE-------TIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKL 156 + AP G A+ + + Q G+ +L VHRDL N LV T+K+ Sbjct: 686 AEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKI 745 Query: 157 ADFGLAR-IYS--YQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 ADFG++R +Y+ Y V+ + + A E +L + T D+W+ G E+ Sbjct: 746 ADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVL 800 >5XD6-A nrPDB Length = 305 Score = 60.5 bits (145), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 52/194 (26%), Positives = 85/194 (43%), Gaps = 45/194 (23%) Query: 56 EVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAE 115 + A +++L++ + P+ L V SR +E V L+ VD LR + P G Sbjct: 47 KAAAIKKLDSSKQPDQEFLAQVSMVSRLRQENVVALLGYCVDGPLRVLAYEYAPNG---- 102 Query: 116 TIKDLMRQ------------------------FLRGLDFLHANC---IVHRDLKPENILV 148 ++ D++ RGL++LH ++HRD+K N+L+ Sbjct: 103 SLHDILHGRKGVKGAQPGPVLSWHQRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLL 162 Query: 149 TSGGTVKLADFGL--------ARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSV 200 K+ADF L AR++S T V+ T Y APE + T +T D++S Sbjct: 163 FDDDVAKIADFDLSNQAPDMAARLHS-----TRVLGTFGYHAPEYAMTGTLSTKSDVYSF 217 Query: 201 GCIFAEMFR-RKPL 213 G + E+ RKP+ Sbjct: 218 GVVLLELLTGRKPV 231 >1AD5-A nrPDB Length = 438 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 52/198 (26%), Positives = 88/198 (44%), Gaps = 25/198 (12%) Query: 11 EIGVGAYGTVYKAR-DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHP 69 ++G G +G V+ A + H+ VA+K+++ G + + +A ++ +H Sbjct: 189 KLGAGQFGEVWMATYNKHTK--VAVKTMK-------PGSMSVEAF--LAEANVMKTLQHD 237 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 +V+L V T I + F L +L P + D Q G+ Sbjct: 238 KLVKLHAVV----TKEPIYIITEF-MAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 292 Query: 130 FLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQS 189 F+ +HRDL+ NILV++ K+ADFGLAR+ A P+ T APE + Sbjct: 293 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARV----GAKFPIKWT----APEAINFG 344 Query: 190 TYATPVDMWSVGCIFAEM 207 ++ D+WS G + E+ Sbjct: 345 SFTIKSDVWSFGILLMEI 362 >3BEA-A nrPDB Length = 333 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 90/209 (43%), Gaps = 14/209 (6%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPN-GGGGGGGLPISTVREVALLRRLEAFEHPN 70 +G GA+G V +A G A+ V V + + E+ ++ L +H N Sbjct: 54 LGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG--QHEN 111 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRT---YLDKAPPPGLPAETI--KDLMR--- 122 +V L+ C I + + LR L+ P + T+ +DL+ Sbjct: 112 IVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKSRVLETDPAFAIANSTLSTRDLLHFSS 171 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY---SYQMALTPVVVTLW 179 Q +G+ FL + +HRD+ N+L+T+G K+ DFGLAR S + + + Sbjct: 172 QVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVK 231 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 + APE + Y D+WS G + E+F Sbjct: 232 WMAPESIFDCVYTVQSDVWSYGILLWEIF 260 >4AW2-A nrPDB Length = 437 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 45/141 (31%), Positives = 67/141 (47%), Gaps = 8/141 (5%) Query: 95 HVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTV 154 +V DL T L K LP E + + + + +D +H VHRD+KP+NIL+ G + Sbjct: 156 YVGGDLLTLLSKFEDR-LPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHI 214 Query: 155 KLADFG--LARIYSYQMALTPVVVTLWYRAPEVLL-----QSTYATPVDMWSVGCIFAEM 207 +LADFG L + + + V T Y +PE+L + Y D WS+G EM Sbjct: 215 RLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEGGKGRYGPECDWWSLGVCMYEM 274 Query: 208 FRRKPLFCGNSEADQLGKIFD 228 + F S + GKI + Sbjct: 275 LYGETPFYAESLVETYGKIMN 295 >4FL3-A nrPDB Length = 635 Score = 59.7 bits (143), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 39/151 (25%), Positives = 72/151 (47%), Gaps = 13/151 (8%) Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLM 121 ++ ++P +VR++ +C LV E + L YL + + + I +L+ Sbjct: 424 MQQLDNPYIVRMIGICEAE------SWMLVMEMAELGPLNKYLQQNRH--VKDKNIIELV 475 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALTPVVVT 177 Q G+ +L + VHRDL N+L+ + K++DFGL++ +Y A T Sbjct: 476 HQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWP 535 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 + + APE + +++ D+WS G + E F Sbjct: 536 VKWYAPECINYYKFSSKSDVWSFGVLMWEAF 566 >3A4O-X nrPDB Length = 286 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 55/238 (23%), Positives = 105/238 (44%), Gaps = 19/238 (7%) Query: 9 VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 V +G G +G V+ +S VA+K+++ G + + E A L ++ +H Sbjct: 18 VKRLGAGQFGEVWMGYYNNSTK-VAVKTLK-------PGTMSVQAFLEEANL--MKTLQH 67 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 +VRL V RE + ++ E++ + L +L + + D Q G Sbjct: 68 DKLVRLYAVVT-----REEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEG 122 Query: 128 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY--SYQMALTPVVVTLWYRAPEV 185 + ++ +HRDL+ N+LV+ K+ADFGLAR+ + A + + APE Sbjct: 123 MAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEA 182 Query: 186 LLQSTYATPVDMWSVGCIFAEMFRRKPL-FCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 + + D+WS G + E+ + + G + AD + + +P ++ P ++ Sbjct: 183 INFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDEL 240 >2VD5-A nrPDB Length = 412 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 49/151 (32%), Positives = 73/151 (48%), Gaps = 11/151 (7%) Query: 86 EIKVTLVFEH-VDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPE 144 E + LV E+ V DL T L K +PAE + + + + +D +H VHRD+KP+ Sbjct: 133 ENYLYLVMEYYVGGDLLTLLSKFGER-IPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPD 191 Query: 145 NILVTSGGTVKLADFGLARIYSYQMALTPVVV--TLWYRAPEVL-------LQSTYATPV 195 NIL+ G ++LADFG + +V T Y +PE+L +Y Sbjct: 192 NILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPEC 251 Query: 196 DMWSVGCIFAEMFRRKPLFCGNSEADQLGKI 226 D W++G EMF + F +S A+ GKI Sbjct: 252 DWWALGVFAYEMFYGQTPFYADSTAETYGKI 282 >2HK5-A nrPDB Length = 270 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 50/200 (25%), Positives = 88/200 (44%), Gaps = 19/200 (9%) Query: 11 EIGVGAYGTVYKAR-DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHP 69 ++G G +G V+ A + H+ VA+K+++ G + + +A ++ +H Sbjct: 22 KLGAGQFGEVWMATYNKHTK--VAVKTMK-------PGSMSVEAF--LAEANVMKTLQHD 70 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 +V+L V T I + F L +L P + D Q G+ Sbjct: 71 KLVKLHAVV----TKEPIYIITEF-MAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 125 Query: 130 FLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY--SYQMALTPVVVTLWYRAPEVLL 187 F+ +HRDL+ NILV++ K+ADFGLAR+ + A + + APE + Sbjct: 126 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 185 Query: 188 QSTYATPVDMWSVGCIFAEM 207 ++ D+WS G + E+ Sbjct: 186 FGSFTIKSDVWSFGILLMEI 205 >4EBW-A nrPDB Length = 304 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 75/274 (27%), Positives = 117/274 (42%), Gaps = 30/274 (10%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL--EAFEHP 69 IG G +G D H G +++ ++ + +VRE L L F+HP Sbjct: 46 IGEGQFG------DVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHP 99 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 ++V+L+ V E V ++ E +LR++L + L ++ Q L Sbjct: 100 HIVKLIGVIT------ENPVWIIMELCTLGELRSFL-QVRKYSLDLASLILYAYQLSTAL 152 Query: 129 DFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY---SYQMALTPVVVTLWYRAPEV 185 +L + VHRD+ N+LV+S VKL DFGL+R +Y A + W APE Sbjct: 153 AYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM-APES 211 Query: 186 LLQSTYATPVDMWSVGCIFAEMFRR--KPLFCGNSEADQLGKIFDLIGLP-PEDDWPRDV 242 + + + D+W G E+ KP F G D +G+I + LP P + P Sbjct: 212 INFRRFTSASDVWMFGVCMWEILMHGVKP-FQGVKNNDVIGRIENGERLPMPPNCPPTLY 270 Query: 243 SLPRGAF---PPRGPRPVQ---SVVPEMEESGAQ 270 SL + P R PR + + +EE AQ Sbjct: 271 SLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQ 304 >3VHK-A nrPDB Length = 368 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 32/89 (35%), Positives = 47/89 (52%), Gaps = 3/89 (3%) Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYS--YQMALTPVVVTLW 179 Q +G++FL + +HRDL NIL++ VK+ DFGLAR IY + + L Sbjct: 208 QVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLK 267 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 + APE + Y D+WS G + E+F Sbjct: 268 WMAPETIFDRVYTIQSDVWSFGVLLWEIF 296 >5C26-A nrPDB Length = 299 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 50/203 (24%), Positives = 90/203 (44%), Gaps = 17/203 (8%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 E+G G +GTV K + + N L + E ++++L+ +P Sbjct: 34 ELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPA-LKDELLAEANVMQQLD---NPY 89 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 +VR++ +C LV E + L YL + + + I +L+ Q G+ Sbjct: 90 IVRMIGICEAESW------MLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQVSMGMK 141 Query: 130 FLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALTPVVVTLWYRAPEV 185 +L + VHRDL N+L+ + K++DFGL++ +Y A T + + APE Sbjct: 142 YLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPEC 201 Query: 186 LLQSTYATPVDMWSVGCIFAEMF 208 + +++ D+WS G + E F Sbjct: 202 INYYKFSSKSDVWSFGVLMWEAF 224 >6F3F-A nrPDB Length = 455 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 54/204 (26%), Positives = 94/204 (46%), Gaps = 27/204 (13%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 ++G G +G V+ + VA+K+++ G P + ++E ++++L H Sbjct: 194 KLGQGCFGEVWMGTWNGTTR-VAIKTLK------PGTMSPEAFLQEAQVMKKLR---HEK 243 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 +V+L V + E + +V E++++ L +L L + D+ Q G+ Sbjct: 244 LVQLYAVVS------EEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMA 297 Query: 130 FLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY------SYQMALTPVVVTLWYRAP 183 ++ VHRDL+ NILV K+ADFGLAR+ + Q A P+ T AP Sbjct: 298 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT----AP 353 Query: 184 EVLLQSTYATPVDMWSVGCIFAEM 207 E L + D+WS G + E+ Sbjct: 354 EAALYGRFTIKSDVWSFGILLTEL 377 >2OZO-A nrPDB Length = 613 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 51/204 (25%), Positives = 88/204 (43%), Gaps = 23/204 (11%) Query: 11 EIGVGAYGTV----YKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF 66 E+G G +G+V Y+ R VA+K ++ G +RE ++ +L+ Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQID--VAIKVLK----QGTEKADTEEMMREAQIMHQLD-- 394 Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLR 126 +P +VRL+ VC + LV E +P + +L+ Q Sbjct: 395 -NPYIVRLIGVCQAE------ALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSM 447 Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALTPVVVTLWYRA 182 G+ +L VHR+L N+L+ + K++DFGL++ SY A + L + A Sbjct: 448 GMKYLEEKNFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYA 507 Query: 183 PEVLLQSTYATPVDMWSVGCIFAE 206 PE + +++ D+WS G E Sbjct: 508 PECINFRKFSSRSDVWSYGVTMWE 531 >6GVJ-A nrPDB Length = 429 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 67/251 (26%), Positives = 106/251 (42%), Gaps = 35/251 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y + +IG G V++ + A+K V + S E+A L +L+ Sbjct: 146 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLD---SYRNEIAYLNKLQ- 200 Query: 66 FEHPN-VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 +H + ++RL D T + + +V E + DL ++L K P E K + Sbjct: 201 -QHSDKIIRLYDYEITDQY-----IYMVMECGNIDLNSWLKKKKSID-PWER-KSYWKNM 252 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-----TLW 179 L + +H + IVH DLKP N L+ G +KL DFG+A Q T VV T+ Sbjct: 253 LEAVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIAN--QMQPDTTSVVKDSQVGTVN 309 Query: 180 YRAPEVLLQSTYA-----------TPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD 228 Y PE + + + D+WS+GCI M K F +Q+ K+ Sbjct: 310 YMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF--QQIINQISKLHA 367 Query: 229 LIGLPPEDDWP 239 +I E ++P Sbjct: 368 IIDPNHEIEFP 378 >3PLS-A nrPDB Length = 298 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 59/218 (27%), Positives = 92/218 (42%), Gaps = 41/218 (18%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF----- 66 IG G +G VY G ++ R+ I ++ + ++++EAF Sbjct: 29 IGKGHFGVVYH------GEYIDQAQNRIQCA--------IKSLSRITEMQQVEAFLREGL 74 Query: 67 -----EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 HPNV+ L+ + + L+ DL ++ ++P T+KDL+ Sbjct: 75 LMRGLNHPNVLALIGIMLPPEG---LPHVLLPYMCHGDLLQFI-RSPQRN---PTVKDLI 127 Query: 122 R---QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR------IYSYQMALT 172 Q RG+++L VHRDL N ++ TVK+ADFGLAR YS Q Sbjct: 128 SFGLQVARGMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRH 187 Query: 173 PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRR 210 + W A E L + T D+WS G + E+ R Sbjct: 188 ARLPVKW-TALESLQTYRFTTKSDVWSFGVLLWELLTR 224 >2H8H-A nrPDB Length = 535 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 54/204 (26%), Positives = 93/204 (45%), Gaps = 27/204 (13%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 ++G G +G V+ + VA+K+++ G P + ++E ++++L H Sbjct: 274 KLGQGCFGEVWMGTWNGTTR-VAIKTLKP------GTMSPEAFLQEAQVMKKLR---HEK 323 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 +V+L V + E + +V E++ + L +L L + D+ Q G+ Sbjct: 324 LVQLYAVVS------EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 377 Query: 130 FLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY------SYQMALTPVVVTLWYRAP 183 ++ VHRDL+ NILV K+ADFGLAR+ + Q A P+ T AP Sbjct: 378 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT----AP 433 Query: 184 EVLLQSTYATPVDMWSVGCIFAEM 207 E L + D+WS G + E+ Sbjct: 434 EAALYGRFTIKSDVWSFGILLTEL 457 >4Y83-A nrPDB Length = 332 Score = 58.5 bits (140), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 49/184 (26%), Positives = 80/184 (43%), Gaps = 34/184 (18%) Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL-TPVVVTL 178 + + L+GLDFLH+ ++H D+KP NI+ S V L DFGL+ + + + T Sbjct: 170 VTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTE 228 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y +PEV+L ++T D++S+G M G PP W Sbjct: 229 IYMSPEVILCRGHSTKADIYSLGATLIHM---------------------QTGTPP---W 264 Query: 239 PRDVSLPRGAFPP------RGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQH 292 + PR A+P + P++ + + +L+ L NP+ R A L+H Sbjct: 265 VK--RYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKH 322 Query: 293 SYLH 296 L+ Sbjct: 323 EALN 326 >3HMP-A nrPDB Length = 342 Score = 58.5 bits (140), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 67/251 (26%), Positives = 106/251 (42%), Gaps = 35/251 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y + +IG G V++ + A+K V + S E+A L +L+ Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLD---SYRNEIAYLNKLQ- 112 Query: 66 FEHPN-VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 +H + ++RL D T + + +V E + DL ++L K P E K + Sbjct: 113 -QHSDKIIRLYDYEITDQY-----IYMVMECGNIDLNSWLKKKKSID-PWER-KSYWKNM 164 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-----TLW 179 L + +H + IVH DLKP N L+ G +KL DFG+A Q T VV T+ Sbjct: 165 LEAVHTIHQHGIVHSDLKPANFLIVD-GMLKLIDFGIAN--QMQPDTTSVVKDSQVGTVN 221 Query: 180 YRAPEVLLQSTYA-----------TPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD 228 Y PE + + + D+WS+GCI M K F +Q+ K+ Sbjct: 222 YMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF--QQIINQISKLHA 279 Query: 229 LIGLPPEDDWP 239 +I E ++P Sbjct: 280 IIDPNHEIEFP 290 >5UIU-A nrPDB Length = 323 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 32/90 (35%), Positives = 49/90 (54%), Gaps = 4/90 (4%) Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI---YSYQMALTPVVVTLWYRA 182 G++FLH N +HRD+K NIL+ T K++DFGLAR ++ + + +V T Y A Sbjct: 160 NGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMA 219 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKP 212 PE L+ D++S G + E+ P Sbjct: 220 PEA-LRGEITPKSDIYSFGVVLLEIITGLP 248 >4X7Q-B nrPDB Length = 312 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 75/261 (28%), Positives = 110/261 (42%), Gaps = 25/261 (9%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSV-RVPNGGGGGGGLPISTVREVALLRRLEAFE-HP 69 +G G +GTV+ VA+K + R G ++ EVALL ++ A HP Sbjct: 39 LGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHP 98 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHV--DQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 V+RL+D T LV E QDL Y+ + P G + Q + Sbjct: 99 GVIRLLDWFETQE-----GFMLVLERPLPAQDLFDYITEKGPLG--EGPSRCFFGQVVAA 151 Query: 128 LDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVL 186 + H+ +VHRD+K ENIL+ G KL DFG + + T T Y PE + Sbjct: 152 IQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALL-HDEPYTDFDGTRVYSPPEWI 210 Query: 187 LQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP 245 + Y A P +WS+G + +M CG+ ++ +I + E +P VS Sbjct: 211 SRHQYHALPATVWSLGILLYDM------VCGDIPFERDQEILEA-----ELHFPAHVSPD 259 Query: 246 RGAFPPRGPRPVQSVVPEMEE 266 A R P S P +EE Sbjct: 260 CCALIRRCLAPKPSSRPSLEE 280 >2H34-A nrPDB Length = 309 Score = 58.2 bits (139), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 60/209 (28%), Positives = 89/209 (42%), Gaps = 13/209 (6%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G G G VY+A D VALK + P+ R R + P+V Sbjct: 42 VGRGGMGDVYEAEDTVRERIVALKLMSETLSSD-----PVFRTRMQREARTAGRLQEPHV 96 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFL 131 V + D D ++ V + + DL L + P P ++RQ LD Sbjct: 97 VPIHDF---GEIDGQLYVDMRLIN-GVDLAAMLRRQGPLAPPRAVA--IVRQIGSALDAA 150 Query: 132 HANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ--MALTPVVVTLWYRAPEVLLQS 189 HA HRD+KPENILV++ L DFG+A + + L V TL+Y APE +S Sbjct: 151 HAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFSES 210 Query: 190 TYATPVDMWSVGCIFAEMFRRKPLFCGNS 218 D++++ C+ E P + G+ Sbjct: 211 HATYRADIYALTCVLYECLTGSPPYQGDQ 239 >6ED6-A nrPDB Length = 415 Score = 58.2 bits (139), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 62/246 (25%), Positives = 95/246 (38%), Gaps = 42/246 (17%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 M Y+ V IG GA+G V R S A+K LL Sbjct: 85 MKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMK-----------------------LL 121 Query: 61 RRLEAFEHPNVVRLM---DVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGL----- 112 + E + + D+ A + + +++ F+ D+ L ++ P L Sbjct: 122 SKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQD-DRYLYMVMEYMPGGDLVNLMS 180 Query: 113 ----PAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFG--LARIYS 166 P + K + + LD +H+ ++HRD+KP+N+L+ G +KLADFG + + Sbjct: 181 NYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDET 240 Query: 167 YQMALTPVVVTLWYRAPEVLLQST----YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQ 222 + V T Y +PEVL Y D WSVG EM F +S Sbjct: 241 GMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGT 300 Query: 223 LGKIFD 228 KI D Sbjct: 301 YSKIMD 306 >4PDO-A nrPDB Length = 299 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 51/209 (24%), Positives = 89/209 (42%), Gaps = 28/209 (13%) Query: 12 IGVGAYGTVYKAR-DPHSGHF---VALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 IG G +G VYK SG VA+K+++ G + + E ++ + F Sbjct: 42 IGAGEFGEVYKGMLKTSSGKKEVPVAIKTLK----AGYTEKQRVDFLGEAGIMGQ---FS 94 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 H N++RL V + + + ++ E+++ + + ++R G Sbjct: 95 HHNIIRLEGVISKYKP-----MMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAG 149 Query: 128 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI--------YSYQMALTPVVVTLW 179 + +L VHRDL NILV S K++DFGL+R+ Y+ P+ T Sbjct: 150 MKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWT-- 207 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 APE + + + D+WS G + E+ Sbjct: 208 --APEAISYRKFTSASDVWSFGIVMWEVM 234 >1TKI-A nrPDB Length = 321 Score = 57.8 bits (138), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 49/202 (24%), Positives = 89/202 (44%), Gaps = 18/202 (8%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 +Y ++G G +G V++ + S K V+V G + +E+++L Sbjct: 6 KYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVK------GTDQVLVKKEISILN--- 56 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQ 123 H N++ L + + ++ ++FE + D+ ++ + L I + Q Sbjct: 57 IARHRNILHLHESFESME-----ELVMIFEFISGLDIFERINTSAFE-LNEREIVSYVHQ 110 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTS--GGTVKLADFGLARIYSYQMALTPVVVTLWYR 181 L FLH++ I H D++PENI+ + T+K+ +FG AR + Y Sbjct: 111 VCEALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYY 170 Query: 182 APEVLLQSTYATPVDMWSVGCI 203 APEV +T DMWS+G + Sbjct: 171 APEVHQHDVVSTATDMWSLGTL 192 >3DKO-A nrPDB Length = 318 Score = 57.8 bits (138), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 55/209 (26%), Positives = 85/209 (40%), Gaps = 29/209 (13%) Query: 12 IGVGAYGTVYKARDPHSGH---FVALKSVRVPNGGGGGGGLPISTVRE-VALLRRLEAFE 67 IG G +G V R G VA+K+++V G R+ + + F+ Sbjct: 51 IGAGEFGEVCSGRLKLPGKRDVAVAIKTLKV--------GYTEKQRRDFLCEASIMGQFD 102 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 HPNVV L V + V +V E ++ + + ++R G Sbjct: 103 HPNVVHLEGVVTRGKP-----VMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAG 157 Query: 128 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR--------IYSYQMALTPVVVTLW 179 + +L VHRDL NILV S K++DFGL+R +Y+ PV T Sbjct: 158 MRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWT-- 215 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 APE + + + D+WS G + E+ Sbjct: 216 --APEAIQYRKFTSASDVWSYGIVMWEVM 242 >5AP3-A nrPDB Length = 313 Score = 57.4 bits (137), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 67/251 (26%), Positives = 105/251 (41%), Gaps = 35/251 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y + +IG G V++ + A+K V + S E+A L +L+ Sbjct: 30 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLD---SYRNEIAYLNKLQ- 84 Query: 66 FEHPN-VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 +H + ++RL D T + + +V E + DL +L K P E K + Sbjct: 85 -QHSDKIIRLYDYEITDQY-----IYMVMECGNIDLNGWLKKKKSID-PWER-KSYWKNM 136 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-----TLW 179 L + +H + IVH DLKP N L+ G +KL DFG+A Q T VV T+ Sbjct: 137 LEAVHTIHQHGIVHSDLKPANFLIVD-GMLKLIDFGIAN--QMQPDTTSVVKDSQVGTVN 193 Query: 180 YRAPEVLLQSTYA-----------TPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD 228 Y PE + + + D+WS+GCI M K F +Q+ K+ Sbjct: 194 YMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF--QQIINQISKLHA 251 Query: 229 LIGLPPEDDWP 239 +I E ++P Sbjct: 252 IIDPNHEIEFP 262 >3PP0-A nrPDB Length = 338 Score = 57.4 bits (137), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 57/226 (25%), Positives = 92/226 (40%), Gaps = 48/226 (21%) Query: 9 VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR------ 62 V +G GA+GTVYK + +P+G + I +RE + Sbjct: 22 VKVLGSGAFGTVYKG-------------IWIPDGENVKIPVAIKVLRENTSPKANKEILD 68 Query: 63 ----LEAFEHPNVVRLMDVCATSRTDREIKVT---LVFEHVDQDLRTYLDKAPPPGLPAE 115 + P V RL+ +C TS ++ + +HV ++ L ++ Sbjct: 69 EAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGR---------LGSQ 119 Query: 116 TIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-------YSYQ 168 + + Q +G+ +L +VHRDL N+LV S VK+ DFGLAR+ Y Sbjct: 120 DLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHAD 179 Query: 169 MALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEM--FRRKP 212 P+ + A E +L+ + D+WS G E+ F KP Sbjct: 180 GGKVPIK----WMALESILRRRFTHQSDVWSYGVTVWELMTFGAKP 221 >2J0K-A nrPDB Length = 656 Score = 57.4 bits (137), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 62/230 (26%), Positives = 100/230 (43%), Gaps = 23/230 (10%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL--EAFEHP 69 IG G +G D H G +++ ++ + +VRE L L F+HP Sbjct: 398 IGEGQFG------DVHQGIYMSPENPAMAVAIKTCKNCTSDSVREKFLQEALTMRQFDHP 451 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 ++V+L+ V E V ++ E +LR++L + L ++ Q L Sbjct: 452 HIVKLIGVIT------ENPVWIIMELCTLGELRSFL-QVRKFSLDLASLILYAYQLSTAL 504 Query: 129 DFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY---SYQMALTPVVVTLWYRAPEV 185 +L + VHRD+ N+LV++ VKL DFGL+R +Y A + W APE Sbjct: 505 AYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWM-APES 563 Query: 186 LLQSTYATPVDMWSVGCIFAEMFRR--KPLFCGNSEADQLGKIFDLIGLP 233 + + + D+W G E+ KP F G D +G+I + LP Sbjct: 564 INFRRFTSASDVWMFGVCMWEILMHGVKP-FQGVKNNDVIGRIENGERLP 612 >5FM2-A nrPDB Length = 355 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 59/223 (26%), Positives = 92/223 (41%), Gaps = 35/223 (15%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G G +G V KA H +V V P ++ L+ HP+V Sbjct: 72 LGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENAS--PSELRDLLSEFNVLKQVNHPHV 129 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPP-------------------PG 111 ++L C+ ++ + L+ E+ LR +L ++ P Sbjct: 130 IKLYGACS-----QDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPD 184 Query: 112 LPAETIKDLMR---QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IY-- 165 A T+ DL+ Q +G+ +L +VHRDL NILV G +K++DFGL+R +Y Sbjct: 185 ERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEE 244 Query: 166 -SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEM 207 SY + W A E L Y T D+WS G + E+ Sbjct: 245 DSYVKRSQGRIPVKWM-AIESLFDHIYTTQSDVWSFGVLLWEI 286 >5WNL-A nrPDB Length = 342 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 52/212 (24%), Positives = 99/212 (46%), Gaps = 24/212 (11%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 ++G G +G VYK R H ++A+K L + + LL + E Sbjct: 27 KVGSGGFGQVYKVRHVHWKTWLAIKC---------SPSLHVDDRERMELLEEAKKMEMAK 77 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 ++ V + V LV E+++ L + P LP + ++ + G++F Sbjct: 78 FRYILPVYGICQE----PVGLVMEYMETGSLEKLLASEP--LPWDLRFRIVHETAVGMNF 131 Query: 131 LHANC--IVHRDLKPENILVTSGGTVKLADFGLARI----YSYQMALTPVVVTLWYRAPE 184 LH ++H +LKP NIL+ + VK++DFGLA+ +S+ +++ + T+ Y PE Sbjct: 132 LHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPE 191 Query: 185 VLLQST--YATPVDMWSVG-CIFAEMFRRKPL 213 + + + + T D++S I+ + ++KP Sbjct: 192 RIREKSRLFDTKHDVYSFAIVIWGVLTQKKPF 223 >3TKU-A nrPDB Length = 433 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 43/141 (30%), Positives = 66/141 (46%), Gaps = 8/141 (5%) Query: 95 HVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTV 154 +V DL T L K LP + + + + + +D +H VHRD+KP+N+L+ G + Sbjct: 172 YVGGDLLTLLSKFEDK-LPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHI 230 Query: 155 KLADFG-LARIYSYQMALTPVVV-TLWYRAPEVLL-----QSTYATPVDMWSVGCIFAEM 207 +LADFG ++ + V V T Y +PE+L Y D WS+G EM Sbjct: 231 RLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEM 290 Query: 208 FRRKPLFCGNSEADQLGKIFD 228 + F S + GKI + Sbjct: 291 LYGETPFYAESLVETYGKIMN 311 >6BFN-A nrPDB Length = 342 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 60/219 (27%), Positives = 90/219 (41%), Gaps = 20/219 (9%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 T + +IG G +G VY+A ++ + A+K ++ N + S + EV L Sbjct: 20 GTHNFSEELKIGEGGFGCVYRAVMRNTVY--AVKRLK-ENADLEWTAVKQSFLTEVEQLS 76 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 R F HPN+V CA + + L ++ L PP P D++ Sbjct: 77 R---FRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRL--DIL 131 Query: 122 RQFLRGLDFLHANC--IVHRDLKPENILVTSGGTVKLADFGLARI---------YSYQMA 170 R + FLH + ++H D+K N+L+ T KL DFGLAR S +A Sbjct: 132 LGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSSMVA 191 Query: 171 LTPVVV-TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 T V TL Y E + A D +S G + E Sbjct: 192 RTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETL 230 >3G0E-A nrPDB Length = 336 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 32/90 (35%), Positives = 44/90 (48%), Gaps = 5/90 (5%) Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALTPVVVTL 178 Q +G+ FL + +HRDL NIL+T G K+ DFGLAR +Y + + Sbjct: 176 QVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVK 235 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 W APE + Y D+WS G E+F Sbjct: 236 W-MAPESIFNCVYTFESDVWSYGIFLWELF 264 >6CKI-A nrPDB Length = 316 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 52/199 (26%), Positives = 75/199 (37%), Gaps = 50/199 (25%) Query: 127 GLDFLHANCIVHRDLKPENILV---TSGGTVKLADFGLARIYSYQMALTPVVV------- 176 LDFLH I HRDLKPENIL VK+ DFGL +P+ Sbjct: 123 ALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTPC 182 Query: 177 -TLWYRAPEVL-----LQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLI 230 + Y APEV+ S Y D+WS+G I + P F G +D Sbjct: 183 GSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDC-------- 234 Query: 231 GLPPEDDWPRDVSLP-------------RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLT 277 W R + P + FP + + + L+ ++L Sbjct: 235 ------GWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKD-------LISKLLV 281 Query: 278 FNPHKRISAFRALQHSYLH 296 + +R+SA + LQH ++ Sbjct: 282 RDAKQRLSAAQVLQHPWVQ 300 >5SYS-A nrPDB Length = 286 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 53/204 (25%), Positives = 92/204 (45%), Gaps = 27/204 (13%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 ++G G +G + + VA+K+++ G P + ++E ++++L H Sbjct: 25 KLGQGCFGECWMGTWNGTTR-VAIKTLK------PGTMSPEAFLQEAQVMKKLR---HEK 74 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 +V+L V + E + +V E++ + L +L L + D+ Q G+ Sbjct: 75 LVQLYAVVS------EEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMA 128 Query: 130 FLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY------SYQMALTPVVVTLWYRAP 183 ++ VHRDL+ NILV K+ADFGLAR+ + Q A P+ T AP Sbjct: 129 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWT----AP 184 Query: 184 EVLLQSTYATPVDMWSVGCIFAEM 207 E L + D+WS G + E+ Sbjct: 185 EAALYGRFTIKSDVWSFGILLTEL 208 >2ZMD-A nrPDB Length = 390 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 66/252 (26%), Positives = 107/252 (42%), Gaps = 37/252 (14%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVR-EVALLRRLE 64 Y + +IG G V++ + A+K V + + + R E+A L +L+ Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQ----TLDSYRNEIAYLNKLQ 112 Query: 65 AFEHPN-VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 +H + ++RL D T + + +V E + DL ++L K P E K + Sbjct: 113 --QHSDKIIRLYDYEITDQY-----IYMVMECGNIDLNSWLKKKKSID-PWER-KSYWKN 163 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV-----TL 178 L + +H + IVH DLKP N L+ G +KL DFG+A Q T VV + Sbjct: 164 MLEAVHTIHQHGIVHSDLKPANFLIVD-GMLKLIDFGIAN--QMQPDTTSVVKDSQVGAV 220 Query: 179 WYRAPEVLLQSTYA-----------TPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIF 227 Y PE + + + D+WS+GCI M K F +Q+ K+ Sbjct: 221 NYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPF--QQIINQISKLH 278 Query: 228 DLIGLPPEDDWP 239 +I E ++P Sbjct: 279 AIIDPNHEIEFP 290 >6E9W-A nrPDB Length = 443 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 63/239 (26%), Positives = 96/239 (40%), Gaps = 28/239 (11%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 M YE V IG GA+G V R + A+K + + + A Sbjct: 99 MKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLL---------SKFEMIKRSDSAFF 149 Query: 61 ---RRLEAFEH-PNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAE 115 R + AF + P VV+L R + +V E++ DL + +P + Sbjct: 150 WEERDIMAFANSPWVVQLFYAFQDDRY-----LYMVMEYMPGGDLVNLMSNY---DVPEK 201 Query: 116 TIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ--MALTP 173 + + + LD +H+ +HRD+KP+N+L+ G +KLADFG + + + Sbjct: 202 WARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDT 261 Query: 174 VVVTLWYRAPEVLLQS----TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD 228 V T Y +PEVL Y D WSVG EM F +S KI + Sbjct: 262 AVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMN 320 >3MDY-A nrPDB Length = 337 Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 87/318 (27%), Positives = 123/318 (38%), Gaps = 76/318 (23%) Query: 9 VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE- 67 V +IG G YG V+ + G VA+K T E + R E ++ Sbjct: 42 VKQIGKGRYGEVWMGK--WRGEKVAVKV--------------FFTTEEASWFRETEIYQT 85 Query: 68 ----HPNVVRLM--DVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 H N++ + D+ T + +T H + L YL L A+++ L Sbjct: 86 VLMRHENILGFIAADIKGTGSWTQLYLITDY--HENGSLYDYLKSTT---LDAKSMLKLA 140 Query: 122 RQFLRGLDFLHAN--------CIVHRDLKPENILVTSGGTVKLADFGLARIY---SYQMA 170 + GL LH I HRDLK +NILV GT +AD GLA + + ++ Sbjct: 141 YSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVD 200 Query: 171 LTPV--VVTLWYRAPEVLLQS-------TYATPVDMWSVGCIFAEMFRRKPLFCGNSEAD 221 + P V T Y PEVL +S +Y DM+S G I E+ RR C + Sbjct: 201 IPPNTRVGTKRYMPPEVLDESLNRNHFQSYIM-ADMYSFGLILWEVARR----CVS---- 251 Query: 222 QLGKIFDLIGLPPEDDWPRDVSLP-----------RGAFPPRGPRPVQSVVPEMEESGAQ 270 G I + LP D P D S R +FP R E + Sbjct: 252 --GGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSS------DECLRQMGK 303 Query: 271 LLLEMLTFNPHKRISAFR 288 L+ E NP R++A R Sbjct: 304 LMTECWAHNPASRLTALR 321 >3M42-A nrPDB Length = 299 Score = 55.8 bits (133), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 68/297 (22%), Positives = 115/297 (38%), Gaps = 59/297 (19%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVR-VPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +G+G G V + + + ALK ++ P REV L R A + P+ Sbjct: 26 LGLGINGKVLQIFNKRTQEKFALKMLQDCPKAR-----------REVELHWR--ASQCPH 72 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 +VR++DV R+ + +V E +D +L + + ++M+ + Sbjct: 73 IVRIVDVYENLYAGRKC-LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQ 131 Query: 130 FLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVL 186 +LH+ I HRD+KPEN+L TS +KL DFG A+ + + Sbjct: 132 YLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTGE------------------ 173 Query: 187 LQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPR 246 Y DMWS+G I + P F N GL + + + Sbjct: 174 ---KYDKSCDMWSLGVIMYILLCGYPPFYSNH------------GLAISPGMKTRIRMGQ 218 Query: 247 GAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 303 F P P S E+ E L+ +L P +R++ + H ++ + P+ Sbjct: 219 YEF----PNPEWS---EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 268 >4OTD-A nrPDB Length = 341 Score = 55.5 bits (132), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 45/118 (38%), Positives = 66/118 (55%), Gaps = 6/118 (5%) Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-YSYQMALTPVVVTLWYRAPEV 185 GL FLH + IV+RDLK +N+L+ + G VK+ADFGL + Y + T + APEV Sbjct: 126 GLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 185 Query: 186 LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 L ++Y VD W +G + EM + F G+ E + +FD I + E +PR +S Sbjct: 186 LTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEE----VFDSI-VNDEVRYPRFLS 238 >5WNO-A nrPDB Length = 330 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 49/205 (23%), Positives = 88/205 (42%), Gaps = 22/205 (10%) Query: 11 EIGVGAYGTV-----YKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 ++G GA+GTV Y R + VA+K + + E + RL Sbjct: 29 KLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTD------EMLEEATNMFRLR- 81 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 H N+++++ C D +K+ ++ + +L+ +L K L A Q Sbjct: 82 --HDNLLKIIGFCMH---DDGLKIVTIYRPLG-NLQNFL-KLHKENLGAREQVLYCYQIA 134 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY---QMALTPVVVTLWYRA 182 G+ +L +VHRDL N+LV V++ DFGL++I + + + V + + A Sbjct: 135 SGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAIKWLA 194 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEM 207 E+ + Y D+W+ G E+ Sbjct: 195 IEIFSKHCYTHASDVWAFGVTCWEI 219 >3G2F-A nrPDB Length = 336 Score = 54.7 bits (130), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 67/234 (28%), Positives = 97/234 (41%), Gaps = 41/234 (17%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 IG G YG VYK VA+K N + + E + R+ EH N+ Sbjct: 21 IGRGRYGAVYKG--SLDERPVAVKVFSFANRQ--------NFINEKNIY-RVPLMEHDNI 69 Query: 72 VRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 R + D ++ LV E+ + L YL + + L RGL + Sbjct: 70 ARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSS---CRLAHSVTRGLAY 126 Query: 131 LHAN---------CIVHRDLKPENILVTSGGTVKLADFGLA-RIYSYQM--------ALT 172 LH I HRDL N+LV + GT ++DFGL+ R+ ++ A Sbjct: 127 LHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRPGEEDNAAI 186 Query: 173 PVVVTLWYRAPEVLLQS-------TYATPVDMWSVGCIFAEMFRR-KPLFCGNS 218 V T+ Y APEVL + + VDM+++G I+ E+F R LF G S Sbjct: 187 SEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPGES 240 >4YFF-A nrPDB Length = 311 Score = 54.7 bits (130), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 54/202 (26%), Positives = 89/202 (44%), Gaps = 16/202 (7%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 IG G++G VYK R + VA+K R N + + REV++L +L HP V Sbjct: 50 IGSGSFGKVYKGRCRNK--IVAIKRYRA-NTYCSKSDVDM-FCREVSILCQLN---HPCV 102 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFL 131 ++ + C + + +V +++ L L ++ + +G+++L Sbjct: 103 IQFVGACLNDPS----QFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYL 158 Query: 132 H--ANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY--QMALTPVVVTLWYRAPEVLL 187 H I+HRDL NIL+ G +ADFG +R + +T L + APEV Sbjct: 159 HNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMAPEVFT 218 Query: 188 QST-YATPVDMWSVGCIFAEMF 208 Q T Y D++S E+ Sbjct: 219 QCTRYTIKADVFSYALCLWEIL 240 >4G3E-A nrPDB Length = 352 Score = 54.3 bits (129), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 55/204 (26%), Positives = 88/204 (43%), Gaps = 26/204 (12%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G G++G V++ +D +G A+K VR L + V E+ L + P + Sbjct: 82 VGRGSFGEVHRMKDKQTGFQCAVKKVR----------LEVFRVEELVACAGLSS---PRI 128 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFL 131 V L V + E ++ L K LP + + Q L GL++L Sbjct: 129 VPLYGAVREGPW-----VNIFMELLEGGSLGQLIKQMGC-LPEDRALYYLGQALEGLEYL 182 Query: 132 HANCIVHRDLKPENILVTSGGT-VKLADFGLARIYS----YQMALTPVVV--TLWYRAPE 184 H I+H D+K +N+L++S G+ L DFG A + LT + T + APE Sbjct: 183 HTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPE 242 Query: 185 VLLQSTYATPVDMWSVGCIFAEMF 208 V++ VD+WS C+ M Sbjct: 243 VVMGKPCDAKVDIWSSCCMMLHML 266 >4CRS-A nrPDB Length = 341 Score = 53.9 bits (128), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 44/118 (37%), Positives = 67/118 (56%), Gaps = 6/118 (5%) Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-YSYQMALTPVVVTLWYRAPEV 185 GL +LH + IV+RDLK +N+L+ + G VK+ADFGL + Y + T + APEV Sbjct: 126 GLQYLHEHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 185 Query: 186 LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 L +++Y VD W +G + EM + F G+ E + +FD I + E +PR +S Sbjct: 186 LTETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEE----VFDSI-VNDEVRYPRFLS 238 >4IDT-A nrPDB Length = 356 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 53/210 (25%), Positives = 84/210 (40%), Gaps = 38/210 (18%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G G++G V++ D +G A+K VR+ V L P + Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRL-------------EVFRAEELMACAGLTSPRI 128 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFL 131 V L RE +F + + LP + + Q L GL++L Sbjct: 129 VPLYGAV------REGPWVNIFMELLEGGSLGQLVKEQGCLPEDRALYYLGQALEGLEYL 182 Query: 132 HANCIVHRDLKPENILVTSGGT-VKLADFGLARIYSYQMALTP------------VVVTL 178 H+ I+H D+K +N+L++S G+ L DFG A + L P + T Sbjct: 183 HSRRILHGDVKADNVLLSSDGSHAALCDFGHA------VCLQPDGLGKDLLTGDYIPGTE 236 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMF 208 + APEV+L + VD+WS C+ M Sbjct: 237 THMAPEVVLGRSCDAKVDVWSSCCMMLHML 266 >3Q4U-A nrPDB Length = 301 Score = 53.1 bits (126), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 75/296 (25%), Positives = 111/296 (37%), Gaps = 38/296 (12%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G G YG V+ R G VA+K + S RE L + H N+ Sbjct: 16 VGKGRYGEVW--RGSWQGENVAVKIFSSRDEK--------SWFRETELYNTV-MLRHENI 64 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFL 131 + + A+ T R L ++ + D L + ++ GL L Sbjct: 65 LGFI---ASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHL 121 Query: 132 HAN--------CIVHRDLKPENILVTSGGTVKLADFGLARIYS-----YQMALTPVVVTL 178 H I HRDLK +NILV G +AD GLA ++S + P V T Sbjct: 122 HIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTK 181 Query: 179 WYRAPEVLLQSTYA------TPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGL 232 Y APEVL ++ VD+W+ G + E+ RR + D +D++ Sbjct: 182 RYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARR--MVSNGIVEDYKPPFYDVV-- 237 Query: 233 PPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFR 288 P D D+ R P + S A+L+ E NP R++A R Sbjct: 238 -PNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALR 292 >4F9B-A nrPDB Length = 361 Score = 53.1 bits (126), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 41/153 (26%), Positives = 60/153 (39%), Gaps = 32/153 (20%) Query: 111 GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSG-GTVKLADFGLAR------ 163 L + +++ M + L +H IVHRD+KP N L L DFGLA+ Sbjct: 113 SLSFQEVREYMLNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTK 172 Query: 164 -----------------------IYSYQMALTPVVVTLWYRAPEVLLQS-TYATPVDMWS 199 S + + P T +RAPEVL + T +DMWS Sbjct: 173 IELLKFVQSEAQQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWS 232 Query: 200 VGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIG 231 G IF + R P + + + L +I + G Sbjct: 233 AGVIFLSLLSGRYPFYKASDDLTALAQIMTIRG 265 >5TUR-A nrPDB Length = 404 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 92/211 (43%), Gaps = 18/211 (8%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSV---RVPNGGGGGGGLPISTVREVALL 60 S+Y+ +G G +G+VY VA+K V R+ + G G + EV LL Sbjct: 127 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM--EVVLL 184 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD--QDLRTYLDKAPPPGLPAETIK 118 +++ + V+RL+D +R L+ E + QDL ++ + L E + Sbjct: 185 KKVSS-GFSGVIRLLDW-----FERPDSFVLILERPEPVQDLFDFITERG--ALQEELAR 236 Query: 119 DLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALTPVVVT 177 Q L + H ++HRD+K ENIL+ + G +KL DFG + T T Sbjct: 237 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGT 295 Query: 178 LWYRAPEVLLQSTY-ATPVDMWSVGCIFAEM 207 Y PE + Y +WS+G + +M Sbjct: 296 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDM 326 >4BTK-A nrPDB Length = 337 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 46/168 (27%), Positives = 75/168 (44%), Gaps = 22/168 (13%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVR-EVALLRRL 63 R++ + +IG G +G +Y+A D + VALK P ++ EVA+L++L Sbjct: 57 RWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQ--------PKQVLKMEVAVLKKL 108 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPG-LPAETIKDLMR 122 + +H VC R K V + L ++ P G T L + Sbjct: 109 QGKDH--------VCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGK 160 Query: 123 QFLRGLDFLHANCIVHRDLKPENI----LVTSGGTVKLADFGLARIYS 166 Q L ++ +H+ +HRD+KP N L ++ + DFGLAR Y+ Sbjct: 161 QILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYT 208 >4RC3-A nrPDB Length = 289 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 92/211 (43%), Gaps = 18/211 (8%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSV---RVPNGGGGGGGLPISTVREVALL 60 S+Y+ +G G +G+VY VA+K V R+ + G G + EV LL Sbjct: 12 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM--EVVLL 69 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD--QDLRTYLDKAPPPGLPAETIK 118 +++ + V+RL+D +R L+ E + QDL ++ + L E + Sbjct: 70 KKVSS-GFSGVIRLLDW-----FERPDSFVLILERPEPVQDLFDFITERG--ALQEELAR 121 Query: 119 DLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALTPVVVT 177 Q L + H ++HRD+K ENIL+ + G +KL DFG + T T Sbjct: 122 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGT 180 Query: 178 LWYRAPEVLLQSTY-ATPVDMWSVGCIFAEM 207 Y PE + Y +WS+G + +M Sbjct: 181 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDM 211 >4NFN-A nrPDB Length = 309 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 46/168 (27%), Positives = 75/168 (44%), Gaps = 22/168 (13%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVR-EVALLRRL 63 R++ + +IG G +G +Y+A D + VALK P ++ EVA+L++L Sbjct: 22 RWKVLKKIGGGGFGEIYEAMDLLTRENVALKVESAQQ--------PKQVLKMEVAVLKKL 73 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPG-LPAETIKDLMR 122 + +H VC R K V + L ++ P G T L + Sbjct: 74 QGKDH--------VCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGK 125 Query: 123 QFLRGLDFLHANCIVHRDLKPENI----LVTSGGTVKLADFGLARIYS 166 Q L ++ +H+ +HRD+KP N L ++ + DFGLAR Y+ Sbjct: 126 QILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYT 173 >3BGP-A nrPDB Length = 333 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 57/211 (27%), Positives = 92/211 (43%), Gaps = 18/211 (8%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSV---RVPNGGGGGGGLPISTVREVALL 60 S+Y+ +G G +G+VY VA+K V R+ + G G + EV LL Sbjct: 56 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM--EVVLL 113 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD--QDLRTYLDKAPPPGLPAETIK 118 +++ + V+RL+D +R L+ E + QDL ++ + L E + Sbjct: 114 KKVSS-GFSGVIRLLDW-----FERPDSFVLILERPEPVQDLFDFITERG--ALQEELAR 165 Query: 119 DLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALTPVVVT 177 Q L + H ++HRD+K ENIL+ + G +KL DFG + T T Sbjct: 166 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGT 224 Query: 178 LWYRAPEVLLQSTY-ATPVDMWSVGCIFAEM 207 Y PE + Y +WS+G + +M Sbjct: 225 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDM 255 >3LMG-A nrPDB Length = 344 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 49/208 (23%), Positives = 89/208 (42%), Gaps = 28/208 (13%) Query: 12 IGVGAYGTVYKARDPHSGHFVALK-SVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +G G +GTV+K G + + ++V G T +A+ + +H + Sbjct: 39 LGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAI----GSLDHAH 94 Query: 71 VVRLMDVCATSR---TDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 +VRL+ +C S + + + + +HV Q L + + + Q +G Sbjct: 95 IVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRG---------ALGPQLLLNWGVQIAKG 145 Query: 128 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS-------YQMALTPVVVTLWY 180 + +L + +VHR+L N+L+ S V++ADFG+A + Y A TP+ + Sbjct: 146 MYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIK----W 201 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMF 208 A E + Y D+WS G E+ Sbjct: 202 MALESIHFGKYTHQSDVWSYGVTVWELM 229 >1U54-B nrPDB Length = 291 Score = 51.6 bits (122), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 43/129 (33%), Positives = 61/129 (47%), Gaps = 12/129 (9%) Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-----SYQMALTPVVVT 177 Q G+ +L + +HRDL N+L+ + VK+ DFGL R Y M V Sbjct: 129 QVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPF 188 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR--RKPLFCGNSEADQLGKIFDLIG--LP 233 W APE L T++ D W G EMF ++P + G + + L KI D G LP Sbjct: 189 AWC-APESLKTRTFSHASDTWMFGVTLWEMFTYGQEP-WIGLNGSQILHKI-DKEGERLP 245 Query: 234 PEDDWPRDV 242 +D P+D+ Sbjct: 246 RPEDCPQDI 254 >4HZS-A nrPDB Length = 341 Score = 51.6 bits (122), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 43/129 (33%), Positives = 61/129 (47%), Gaps = 12/129 (9%) Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-----SYQMALTPVVVT 177 Q G+ +L + +HRDL N+L+ + VK+ DFGL R Y M V Sbjct: 123 QVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPF 182 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR--RKPLFCGNSEADQLGKIFDLIG--LP 233 W APE L T++ D W G EMF ++P + G + + L KI D G LP Sbjct: 183 AWC-APESLKTRTFSHASDTWMFGVTLWEMFTYGQEP-WIGLNGSQILHKI-DKEGERLP 239 Query: 234 PEDDWPRDV 242 +D P+D+ Sbjct: 240 RPEDCPQDI 248 >1PY5-A nrPDB Length = 326 Score = 51.2 bits (121), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 55/177 (31%), Positives = 78/177 (44%), Gaps = 17/177 (9%) Query: 136 IVHRDLKPENILVTSGGTVKLADFGLARIY-----SYQMALTPVVVTLWYRAPEVLLQST 190 I HRDLK +NILV GT +AD GLA + + +A V T Y APEVL S Sbjct: 155 IAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSI 214 Query: 191 YATP------VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244 D++++G +F E+ RR + G D +DL+ P + R V Sbjct: 215 NMKHFESFKRADIYAMGLVFWEIARRCSI--GGIHEDYQLPYYDLVPSDPSVEEMRKVVC 272 Query: 245 PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQH-SYLHKDEG 300 + P P QS E A+++ E N R++A R + S L + EG Sbjct: 273 EQ-KLRPNIPNRWQSC--EALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEG 326 >4H1J-A nrPDB Length = 293 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 52/212 (24%), Positives = 95/212 (44%), Gaps = 24/212 (11%) Query: 12 IGVGAYGTVYK-ARDPHSGH--FVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 +G G +G VY+ H G VA+K+ + + E +++ L+ H Sbjct: 32 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKF----MSEAVIMKNLD---H 84 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 P++V+L+ + + E ++ + +L YL++ L T+ Q + + Sbjct: 85 PHIVKLIGI-----IEEEPTWIIMELYPYGELGHYLERNKN-SLKVLTLVLYSLQICKAM 138 Query: 129 DFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS----YQMALTPVVVTLWYRAPE 184 +L + VHRD+ NILV S VKL DFGL+R Y+ ++T + + + +PE Sbjct: 139 AYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIK--WMSPE 196 Query: 185 VLLQSTYATPVDMWSVGCIFAEM--FRRKPLF 214 + + T D+W E+ F ++P F Sbjct: 197 SINFRRFTTASDVWMFAVCMWEILSFGKQPFF 228 >4F0G-A nrPDB Length = 287 Score = 49.7 bits (117), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 54/215 (25%), Positives = 93/215 (43%), Gaps = 23/215 (10%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPI--STVREVA 58 +A + E +IG G +G V+K R VA+KS+ + + G + REV Sbjct: 16 LADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVF 75 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIK 118 ++ L HPN+V+L + ++ + F LDKA P + Sbjct: 76 IMSNL---NHPNIVKLYGLMHNPP-----RMVMEFVPCGDLYHRLLDKAHPIKWSVKL-- 125 Query: 119 DLMRQFLRGLDFLHANC--IVHRDLKPENILVTSGG-----TVKLADFGLARIYSYQMAL 171 LM G++++ IVHRDL+ NI + S K+ADFGL++ + ++ Sbjct: 126 RLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVH--SV 183 Query: 172 TPVVVTLWYRAPEVL--LQSTYATPVDMWSVGCIF 204 + ++ + APE + + +Y D +S I Sbjct: 184 SGLLGNFQWMAPETIGAEEESYTEKADTYSFAMIL 218 >5VC6-A nrPDB Length = 289 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 40/157 (25%), Positives = 70/157 (44%), Gaps = 27/157 (17%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 T+ + + +IG G +G+V+K G A+K + P G +V E LR Sbjct: 10 TTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAG---------SVDEQNALRE 60 Query: 63 LEAF----EHPNVVRLMDVCATSR----TDREIKVTLVFEHVDQDLR--TYLDKAPPPGL 112 + A +H +VVR A + + + + ++ R +Y +A Sbjct: 61 VYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAE---- 116 Query: 113 PAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT 149 +KDL+ Q RGL ++H+ +VH D+KP NI ++ Sbjct: 117 ----LKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFIS 149 >5TE0-A nrPDB Length = 347 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 56/211 (26%), Positives = 90/211 (42%), Gaps = 28/211 (13%) Query: 15 GAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRL 74 G + V+ R + G ALK + V N L + RE+ ++R L H N+V Sbjct: 30 GGFAIVFLVRTSN-GMKCALKRMFVNNEHD----LQVCK-REIQIMRDLSG--HKNIVGY 81 Query: 75 MDVCATSRTDREIKVTLVFEHVDQ--DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLH 132 +D + + ++ L+ + + +++ G + + + LH Sbjct: 82 IDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLH 141 Query: 133 ANC---IVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVV----------VTLW 179 C I+HRDLK ENIL+ G L DFG A +Q T V TL Sbjct: 142 -QCKTPIIHRDLKVENILLHDRGHYVLCDFGSA-TNKFQNPQTEGVNAVEDEIKKYTTLS 199 Query: 180 YRAPEVL-LQS--TYATPVDMWSVGCIFAEM 207 YRAPE++ L S T D+W++GC+ ++ Sbjct: 200 YRAPEMVNLYSGKIITTKADIWALGCLLYKL 230 >5E8V-A nrPDB Length = 316 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 43/136 (31%), Positives = 62/136 (45%), Gaps = 23/136 (16%) Query: 95 HVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHAN---C------IVHRDLKPEN 145 H +L+ YL + + E ++ L RG+ LH++ C IVHRDLK N Sbjct: 95 HAKGNLQEYLTRHV---ISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSN 151 Query: 146 ILVTSGGTVKLADFGLA-----RIYSYQMALTPVVVTLWYRAPEVLLQSTYATPV----- 195 ILV + T L DFGL+ + +A + V T Y APEVL + V Sbjct: 152 ILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLASAMNLENVESFKQ 211 Query: 196 -DMWSVGCIFAEMFRR 210 D++S+ + EM R Sbjct: 212 TDVYSMALVLWEMTSR 227 >5VDK-A nrPDB Length = 297 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 43/153 (28%), Positives = 67/153 (43%), Gaps = 17/153 (11%) Query: 3 TSRYEP----VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVA 58 SRYE V +IGVG +GTVYK G A+K + V A Sbjct: 10 ASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNENSALHEVYAHA 69 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAE-- 115 +L HP+VVR A + + + E+ + L+ + + G E Sbjct: 70 VLGH-----HPHVVRYYSSWA-----EDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEP 119 Query: 116 TIKDLMRQFLRGLDFLHANCIVHRDLKPENILV 148 +KD++ Q GL+++H + +VH D+KP NI + Sbjct: 120 KLKDILLQISLGLNYIHNSSMVHLDIKPSNIFI 152 >4M69-B nrPDB Length = 283 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 29/105 (27%), Positives = 58/105 (55%), Gaps = 4/105 (3%) Query: 60 LRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIK 118 ++ ++ F+ PN++R+ +C +T + + ++V E+ + LR LD+ + ++ Sbjct: 59 IKTMKKFDSPNILRIFGIC-IDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSL- 116 Query: 119 DLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR 163 L+ + RGL LH + +HR++ + LV G VKLA F L++ Sbjct: 117 -LVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSK 160 >4Y12-A nrPDB Length = 375 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 51/172 (29%), Positives = 85/172 (49%), Gaps = 19/172 (11%) Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLR 126 HP++V++ + + + +V E+V Q L+ + P AE I L+ + L Sbjct: 177 HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQSLKRSKGQKLPV---AEAIAYLL-EILP 232 Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFG-LARIYSYQMALTPVVVTLWYRAPEV 185 L +LH+ +V+ DLKPENI++T +KL D G ++RI S+ + T ++APE+ Sbjct: 233 ALSYLHSIGLVYNDLKPENIMLTE-EQLKLIDLGAVSRINSFGY----LYGTPGFQAPEI 287 Query: 186 LLQS-TYATPVDMWSVGCIFAEMFRRKPLFCGNS-----EADQLGKIFDLIG 231 + T AT D+++VG A + P G E D + K +D G Sbjct: 288 VRTGPTVAT--DIYTVGRTLAALTLDLPTRNGRYVDGLPEDDPVLKTYDSYG 337 >4BTF-A nrPDB Length = 469 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 29/105 (27%), Positives = 58/105 (55%), Gaps = 4/105 (3%) Query: 60 LRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIK 118 ++ ++ F+ PN++R+ +C +T + + ++V E+ + LR LD+ + ++ Sbjct: 245 IKTMKKFDSPNILRIFGIC-IDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSL- 302 Query: 119 DLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR 163 L+ + RGL LH + +HR++ + LV G VKLA F L++ Sbjct: 303 -LVLRAARGLYRLHHSETLHRNISSSSFLVAGGYQVKLAGFELSK 346 >2Y4I-B nrPDB Length = 319 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 56/219 (25%), Positives = 91/219 (41%), Gaps = 38/219 (17%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 IG G +G VY R H + L + N + REV R+ H NV Sbjct: 41 IGKGRFGQVYHGR-WHGEVAIRLIDIERDNEDQLK-----AFKREVMAYRQTR---HENV 91 Query: 72 VRLMDVCATSRTDREIKVTL----VFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 V M C S I +L V +D + LD + + ++ ++G Sbjct: 92 VLFMGAC-MSPPHLAIITSLCKGRTLYSVVRDAKIVLD--------VNKTRQIAQEIVKG 142 Query: 128 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA------LTPVVVTLWYR 181 + +LHA I+H+DLK +N+ +G V + DFGL I A L L + Sbjct: 143 MGYLHAKGILHKDLKSKNVFYDNGKVV-ITDFGLFSISGVLQAGRREDKLRIQNGWLCHL 201 Query: 182 APEVLLQST---------YATPVDMWSVGCIFAEMFRRK 211 APE++ Q + ++ D++++G I+ E+ R+ Sbjct: 202 APEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHARE 240 >3MY0-A nrPDB Length = 305 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 82/318 (25%), Positives = 119/318 (37%), Gaps = 48/318 (15%) Query: 9 VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 V +G G YG V+ R G VA V++ + + + LLR H Sbjct: 13 VECVGKGRYGEVW--RGLWHGESVA---VKIFSSRDEQSWFRETEIYNTVLLR------H 61 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 N++ + TSR + H L +L + L L GL Sbjct: 62 DNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQT---LEPHLALRLAVSAACGL 118 Query: 129 DFLHAN--------CIVHRDLKPENILVTSGGTVKLADFGLARIYS-----YQMALTPVV 175 LH I HRD K N+LV S +AD GLA ++S + P V Sbjct: 119 AHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNPRV 178 Query: 176 VTLWYRAPEVLLQSTYATP------VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDL 229 T Y APEVL + D+W+ G + E+ RR + G E D +D+ Sbjct: 179 GTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRT-IVNGIVE-DYRPPFYDV 236 Query: 230 I-GLPPEDDWPRDVSLPRG--AFPPR-GPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 + P +D + V + + P R PV S + AQ++ E NP R++ Sbjct: 237 VPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGL-------AQMMRECWYPNPSARLT 289 Query: 286 AFRALQHSYLHKDEGNPE 303 A R L K +PE Sbjct: 290 ALRI--KKTLQKISNSPE 305 >4JRN-A nrPDB Length = 372 Score = 45.8 bits (107), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 31/94 (32%), Positives = 46/94 (48%), Gaps = 10/94 (10%) Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLW 179 L Q ++ + + A IVH D+KP N L+ G + L DFG RI + ++ + T Sbjct: 207 LSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRINN---SVGRAIGTPG 263 Query: 180 YRAPEVLLQS---TYATPVDMWSVG----CIFAE 206 Y PE Q+ TY P D W +G CI+ + Sbjct: 264 YEPPERPFQATGITYTFPTDAWQLGITLYCIWCK 297 >2PZI-A nrPDB Length = 681 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 66/240 (27%), Positives = 108/240 (45%), Gaps = 27/240 (11%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPH-SGHFVALKSVRVPNGGGGGGGLPISTVREVAL 59 + +YE I G G +Y A D + +G V LK + + G R+ Sbjct: 77 IVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGL--VHSGDAEAQAMAMAERQF-- 132 Query: 60 LRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLP-AETIK 118 L HP++V++ + + + +V E+V L ++ LP AE I Sbjct: 133 ---LAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGGQ---SLKRSKGQKLPVAEAIA 186 Query: 119 DLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFG-LARIYSYQMALTPVVVT 177 L+ + L L +LH+ +V+ DLKPENI++T +KL D G ++RI S+ + T Sbjct: 187 YLL-EILPALSYLHSIGLVYNDLKPENIMLTE-EQLKLIDLGAVSRINSFGY----LYGT 240 Query: 178 LWYRAPEVLLQS-TYATPVDMWSVGCIFAEMFRRKPLFCGNS-----EADQLGKIFDLIG 231 ++APE++ T AT D+++VG A + P G E D + K +D G Sbjct: 241 PGFQAPEIVRTGPTVAT--DIYTVGRTLAALTLDLPTRNGRYVDGLPEDDPVLKTYDSYG 298 >5OAT-A nrPDB Length = 411 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 69/246 (28%), Positives = 101/246 (41%), Gaps = 44/246 (17%) Query: 61 RRLEAFEHPNVVRLMDVCAT------------SRTDREIKVTLVFEHVDQDLRTYLDKAP 108 RR HPN+V + V R + + L+ + D +L+++L AP Sbjct: 91 RRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMSLFLLMKRYDCNLQSFLSTAP 150 Query: 109 PPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPEN-----------ILVTSGGTVKLA 157 T L+ Q L G+ + A+ I HRDLK +N ILV S LA Sbjct: 151 S----TRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLA 206 Query: 158 D--FGLARIY-SYQMALTPVVVTLWYRAPEVLLQS--TYA----TPVDMWSVGCIFAEMF 208 D GL+ Y SY+M + APE++ Q T++ + D+W+VG I E+F Sbjct: 207 DKTNGLSLPYTSYEMDKGGNTALM---APEIICQKPGTFSVLNYSKADLWAVGAIAYEIF 263 Query: 209 RRKPLFCGNSEADQLG-KIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEES 267 F G S K DL LP D+ P + R P + + PE+ + Sbjct: 264 NCHNPFYGPSRLKNFNYKEGDLPKLP--DEVPTVIQALVANLLKRNPN--KRLDPEVAAN 319 Query: 268 GAQLLL 273 QL L Sbjct: 320 VCQLFL 325 >3SOC-A nrPDB Length = 322 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 33/103 (32%), Positives = 49/103 (47%), Gaps = 18/103 (17%) Query: 126 RGLDFLHAN----------CIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPV- 174 RGL +LH + I HRD+K +N+L+ + T +ADFGLA + + Sbjct: 132 RGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTH 191 Query: 175 --VVTLWYRAPEVL-----LQSTYATPVDMWSVGCIFAEMFRR 210 V T Y APEVL Q +DM+++G + E+ R Sbjct: 192 GQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASR 234 >4TN6-A nrPDB Length = 318 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 43/178 (24%), Positives = 74/178 (41%), Gaps = 44/178 (24%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALK-------------SVRVPNGGGGGGGLP 50 +RY +IG G++G +Y D +G VA+K ++ GG G+P Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIP 66 Query: 51 ISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPP 110 T+R E V +M++ S +DL + + Sbjct: 67 --TIRWCGA-------EGDYNVMVMELLGPSL---------------EDLFNFCSRK--- 99 Query: 111 GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILV---TSGGTVKLADFGLARIY 165 +T+ L Q + ++++H+ +HRD+KP+N L+ G V + DFGLA+ Y Sbjct: 100 -FSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKY 156 >2QLU-A nrPDB Length = 314 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 36/106 (33%), Positives = 49/106 (46%), Gaps = 23/106 (21%) Query: 126 RGLDFLHAN-----------CIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTP- 173 RGL +LH + I HRD K +N+L+ S T LADFGLA ++ P Sbjct: 123 RGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLA--VRFEPGKPPG 180 Query: 174 ----VVVTLWYRAPEVL-----LQSTYATPVDMWSVGCIFAEMFRR 210 V T Y APEVL Q +DM+++G + E+ R Sbjct: 181 DTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSR 226 >5M07-A nrPDB Length = 276 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 28/105 (26%), Positives = 53/105 (50%), Gaps = 10/105 (9%) Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQFLR 126 HP+++ + D R + + ++ + ++VD D ++ P LP + ++ Sbjct: 89 HPHILEVHD-----RGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAVAG 143 Query: 127 GLDFLHANCIVHRDLKPENILVTSGGT----VKLADFGLARIYSY 167 LD+ H ++HRD+ P N+++TS + LADFG+A SY Sbjct: 144 ALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQPSY 188 >4M66-A nrPDB Length = 325 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 43/153 (28%), Positives = 69/153 (45%), Gaps = 17/153 (11%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G G +G V++A H VA+K V V+ + LR + NV Sbjct: 28 VGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISW--------EVKAMVNLR------NENV 73 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFL 131 + L+ V + D LV ++ L + P P + L+++ + G+ +L Sbjct: 74 LLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPR-PWPLLCRLLQEVVLGMCYL 132 Query: 132 HANC--IVHRDLKPENILVTSGGTVKLADFGLA 162 H+ ++HRDLKP NIL+ KLADFGL+ Sbjct: 133 HSLDPPLLHRDLKPSNILLDPELHAKLADFGLS 165 >3SV0-A nrPDB Length = 483 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 21/57 (36%), Positives = 34/57 (59%), Gaps = 3/57 (5%) Query: 112 LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSG---GTVKLADFGLARIY 165 L +T+ L Q + ++F+H+ +HRD+KP+N L+ G V + DFGLA+ Y Sbjct: 100 LSLKTVLMLADQMINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKY 156 >4MWI-A nrPDB Length = 294 Score = 43.1 bits (100), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 51/189 (26%), Positives = 86/189 (45%), Gaps = 23/189 (12%) Query: 32 VALKSVRVPNGGGGGGGLPISTVREV--ALLRRLEAFEHPNVVRLMDVCATSRTDREIKV 89 VA+K + G I+ VR+ ++ ++ FE PN++R+ +C T + Sbjct: 50 VAIKVFKKLQAGS------IAIVRQTFNKEIKTMKKFESPNILRIFGIC-IDETVTPPQF 102 Query: 90 TLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCI--VHRDLKPENI 146 ++V E+ + LR LD+ L + L+ RGL LH + +H ++ N Sbjct: 103 SIVMEYCELGTLRELLDREKDLTLGKRMV--LVLGAARGLYRLHHSEAPELHGKIRSSNF 160 Query: 147 LVTSGGTVKLADFGLARIYSYQMAL------TPVVVTLWYRAPEVLLQSTYATPV--DMW 198 LVT G VKLA F L + + M+L T V + Y +P+ L Y V +++ Sbjct: 161 LVTQGYQVKLAGFELRKTQT-SMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIY 219 Query: 199 SVGCIFAEM 207 S G + E+ Sbjct: 220 SFGIVLWEI 228 >2WTK-B nrPDB Length = 373 Score = 41.6 bits (96), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 44/156 (28%), Positives = 67/156 (42%), Gaps = 22/156 (14%) Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVF----EHVDQDLRTYLDKAPPPGLPAETIKDLM 121 F HPN+V AT D E+ V F D ++D G+ I ++ Sbjct: 67 FNHPNIVPYR---ATFIADNELWVVTSFMAYGSAKDLICTHFMD-----GMNELAIAYIL 118 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADF--GLARIYSYQMALTP------ 173 + L+ LD++H VHR +K +IL++ G V L+ L+ I Q Sbjct: 119 QGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKY 178 Query: 174 VVVTLWYRAPEVLLQST--YATPVDMWSVGCIFAEM 207 V L + +PEVL Q+ Y D++SVG E+ Sbjct: 179 SVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACEL 214 >4LQP-A nrPDB Length = 508 Score = 41.2 bits (95), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 39/158 (24%), Positives = 69/158 (43%), Gaps = 13/158 (8%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 + V IG GA+G V + +G A+K++ + R+V L Sbjct: 104 FHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDV-----LAG 158 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQF 124 + P VV L ++ + L+ E + DL T L + + + M + Sbjct: 159 SDSPWVVSLYYSFQDAQY-----LYLIMEFLPGGDLMTMLIRWQL--FTEDVTRFYMAEC 211 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLA 162 + ++ +H +HR +KP+NIL+ G +KL+DFGL+ Sbjct: 212 ILAIETIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLS 249 Score = 36.6 bits (83), Expect = 0.012, Method: Compositional matrix adjust. Identities = 21/67 (31%), Positives = 28/67 (41%), Gaps = 5/67 (7%) Query: 163 RIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQ 222 R+ +Y TP Y APE+ L Y D WS+G I E P FC + + Sbjct: 317 RLMAYSTVGTPD-----YIAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQET 371 Query: 223 LGKIFDL 229 KI + Sbjct: 372 YRKIMNF 378 >4IX6-A nrPDB Length = 350 Score = 41.2 bits (95), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 21/49 (42%), Positives = 28/49 (57%), Gaps = 2/49 (4%) Query: 118 KDLMRQFLRGLDFLHANCIVHRDLKPENILVT--SGGTVKLADFGLARI 164 K MR+ L L LH +VHRD+KP N++ GG +KL D G A + Sbjct: 146 KKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAAL 194 >5FQD-C nrPDB Length = 341 Score = 41.2 bits (95), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 43/177 (24%), Positives = 73/177 (41%), Gaps = 44/177 (24%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALK-------------SVRVPNGGGGGGGLPI 51 +Y+ V +IG G++G +Y A + +G VA+K ++ GG G+P Sbjct: 20 KYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPH 79 Query: 52 STVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPG 111 R E V +MD+ S +DL + + Sbjct: 80 I---------RWYGQEKDYNVLVMDLLGPSL---------------EDLFNFCSRR---- 111 Query: 112 LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSG---GTVKLADFGLARIY 165 +T+ L Q + ++++H +HRD+KP+N L+ G + L DFGLA+ Y Sbjct: 112 FTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKY 168 >2C47-A nrPDB Length = 313 Score = 40.8 bits (94), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 18/48 (37%), Positives = 30/48 (62%), Gaps = 5/48 (10%) Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGT-----VKLADFGLARIY 165 Q + ++++H +++RD+KPEN LV GT + + DFGLA+ Y Sbjct: 108 QLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEY 155 >4NT4-A nrPDB Length = 312 Score = 40.8 bits (94), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 18/56 (32%), Positives = 35/56 (62%), Gaps = 5/56 (8%) Query: 115 ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGT-----VKLADFGLARIY 165 +T+ + +Q L ++++H+ +++RD+KPEN L+ T + + DFGLA+ Y Sbjct: 114 KTVLMIAKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEY 169 >2CMW-A nrPDB Length = 310 Score = 40.4 bits (93), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 18/48 (37%), Positives = 30/48 (62%), Gaps = 5/48 (10%) Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVK-----LADFGLARIY 165 Q L ++++H+ +++RD+KPEN L+ G K + DFGLA+ Y Sbjct: 105 QLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEY 152 >4XHH-A nrPDB Length = 403 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 19/54 (35%), Positives = 32/54 (59%), Gaps = 3/54 (5%) Query: 115 ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILV---TSGGTVKLADFGLARIY 165 +T+ L Q + + ++H +HRD+KP+N L+ G TV + DFGL++ Y Sbjct: 103 KTVIMLALQMICRVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKY 156 >4XHL-A nrPDB Length = 394 Score = 40.4 bits (93), Expect = 0.001, Method: Compositional matrix adjust. Identities = 19/54 (35%), Positives = 31/54 (57%), Gaps = 3/54 (5%) Query: 115 ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILV---TSGGTVKLADFGLARIY 165 +T+ L Q + ++H +HRD+KP+N L+ G TV + DFGL++ Y Sbjct: 103 KTVIMLALQMFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKY 156 >5X1R-A nrPDB Length = 302 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 40/179 (22%), Positives = 68/179 (37%), Gaps = 30/179 (16%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPI------------ 51 + +E IG G +G VY+A D +A+K + L I Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 52 ----STVREVALLRRLEAFEHP---NVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYL 104 S ++E LL R F HP +V+R + T+ + +++ + Sbjct: 81 AGLNSFIQEARLLAR---FSHPGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEKI 137 Query: 105 DKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR 163 D+A I+ L+ ++ +H +HRD+ +NI + L DFG AR Sbjct: 138 DEA--------WIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSAR 188 >5AR8-A nrPDB Length = 326 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 31/106 (29%), Positives = 51/106 (48%), Gaps = 11/106 (10%) Query: 120 LMRQFLRGLDFLHANC--IVHRDLKPENILVTSGGTVKLADFGLAR------IYSYQMAL 171 ++ + G+++LH ++H DLK +NIL+ + VK+ADFGL++ S Sbjct: 140 ILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKS 199 Query: 172 TPVVVTLWYRAPEVL---LQSTYATPVDMWSVGCIFAEMFRRKPLF 214 P T+ Y PE +S + D++S I E+ RK F Sbjct: 200 APEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPF 245 >2JII-A nrPDB Length = 352 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 25/77 (32%), Positives = 38/77 (49%), Gaps = 2/77 (2%) Query: 91 LVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILV-- 148 LV + + L++ LD +P L ++ + + L L+FLH N VH ++ ENI V Sbjct: 135 LVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDP 194 Query: 149 TSGGTVKLADFGLARIY 165 V LA +G A Y Sbjct: 195 EDQSQVTLAGYGFAFRY 211 >4CYJ-A nrPDB Length = 438 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 36/169 (21%), Positives = 73/169 (43%), Gaps = 26/169 (15%) Query: 20 VYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREV-ALLRRLEAFEHPNVVRLMDVC 78 VYKA++ +G AL+ + G ++ + + +++ + ++ ++V + +V Sbjct: 71 VYKAQNSRNGRHYALRRLE---------GYRLTNEKAILNVMKDWKKIKNASIVTIHEVF 121 Query: 79 ATSRTDREI-KVTLVFEHVDQDLRTYLDKA-----------PPPGLPAETIKDLMRQFLR 126 T RE +L+F + L L + PPP +P TI + Q Sbjct: 122 TT----REFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIAN 177 Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVV 175 L +H+N + R L+P I++T ++L+ + + + M VV Sbjct: 178 ALKTIHSNRLAARCLEPSKIILTDINRIRLSACAILDVVQFGMNSRSVV 226 >5X18-A nrPDB Length = 295 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 18/59 (30%), Positives = 34/59 (57%), Gaps = 5/59 (8%) Query: 112 LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGG-----TVKLADFGLARIY 165 +T+ + Q + ++ LHA+ +++RD+KP+N L+ G + L DFG+A+ Y Sbjct: 100 FSVKTVVQVAVQMITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQY 158 >4O1O-A nrPDB Length = 717 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 16/50 (32%), Positives = 28/50 (56%) Query: 110 PGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADF 159 P E+ ++++ + + LH + H+DL+P+NIL+ S LADF Sbjct: 437 PNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADF 486 >5L2Q-C nrPDB Length = 320 Score = 37.7 bits (86), Expect = 0.007, Method: Compositional matrix adjust. Identities = 43/173 (24%), Positives = 75/173 (43%), Gaps = 34/173 (19%) Query: 125 LRGLDFLHANCIVHRDLKPENILVTS-GGTVKLADFGLAR-IYSYQMALTPVVVTLWYRA 182 +R ++ LH IVHRDLK N+++ + + +F L + + S L + Y + Sbjct: 163 VRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYIS 222 Query: 183 PEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 P+VL Y P DMW++G + M L G P D Sbjct: 223 PDVLSGRPYRGKPSDMWALGVVLFTM---------------------LYGQFPFYD---- 257 Query: 242 VSLPRGAFPPRGPRPVQSVVPE---MEESGAQLLLEMLTFNPHKRISAFRALQ 291 S+P+ F R + + +PE + E+ L+ ++L +P +R++A L+ Sbjct: 258 -SIPQELF--RKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLE 307 >2CHL-A nrPDB Length = 351 Score = 36.6 bits (83), Expect = 0.013, Method: Compositional matrix adjust. Identities = 15/48 (31%), Positives = 29/48 (60%), Gaps = 5/48 (10%) Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGT-----VKLADFGLARIY 165 Q + ++++H+ +++RD+KPEN L+ G + + DF LA+ Y Sbjct: 134 QLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEY 181 >4OAU-C nrPDB Length = 699 Score = 36.2 bits (82), Expect = 0.016, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 27/46 (58%), Gaps = 1/46 (2%) Query: 115 ETIKDLMRQFLRGLDFLHANC-IVHRDLKPENILVTSGGTVKLADF 159 E ++++ + + LH +C H+DL+P+NIL+ S LADF Sbjct: 439 EFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF 484 >1CSN-A nrPDB Length = 298 Score = 35.4 bits (80), Expect = 0.030, Method: Compositional matrix adjust. Identities = 15/59 (25%), Positives = 30/59 (50%), Gaps = 5/59 (8%) Query: 112 LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILV-----TSGGTVKLADFGLARIY 165 +T+ +Q L + +H +V+RD+KP+N L+ + + + DFG+ + Y Sbjct: 103 FSVKTVAMAAKQMLARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFY 161 >6G4J-A nrPDB Length = 315 Score = 33.9 bits (76), Expect = 0.093, Method: Compositional matrix adjust. Identities = 17/36 (47%), Positives = 21/36 (58%) Query: 114 AETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT 149 AE I LM Q L L LH + DLKP+N++VT Sbjct: 122 AEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVT 157 >4WWA-A nrPDB Length = 261 Score = 33.5 bits (75), Expect = 0.12, Method: Compositional matrix adjust. Identities = 25/76 (32%), Positives = 36/76 (47%), Gaps = 10/76 (13%) Query: 95 HVDQDLRTYL---DKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSG 151 H +L+ +L D+ P L A T++ + RQ + LH N H DL NI++ Sbjct: 117 HGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQ----IGLLHWNDYCHGDLTSSNIVLVRD 172 Query: 152 G---TVKLADFGLARI 164 G T L DFGL + Sbjct: 173 GARWTPHLIDFGLGSV 188 >4L68-A nrPDB Length = 340 Score = 33.1 bits (74), Expect = 0.16, Method: Compositional matrix adjust. Identities = 49/215 (22%), Positives = 83/215 (38%), Gaps = 25/215 (11%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVAL-L 60 AT+ + I GT YKA P G +A+K + G RE + Sbjct: 38 ATNNFNSENIIVSTRTGTTYKALLP-DGSALAVKHLSTCKLG----------EREFRYEM 86 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 +L H N+ L+ C E + LV++++ L + L T + Sbjct: 87 NQLWELRHSNLAPLLGFCVV-----EEEKFLVYKYMSNGTLHSLLDSNRGELDWSTRFRI 141 Query: 121 MRQFLRGLDFLHANC---IVHRDLKPENILVTSGGTVKLADFGLARIY-----SYQMALT 172 RGL +LH C I+H+++ IL+ ++ D GLAR+ + +T Sbjct: 142 GLGAARGLAWLHHGCRPPILHQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMT 201 Query: 173 PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEM 207 + Y APE + D++ +G + E+ Sbjct: 202 GDLGEFGYVAPEYSTTMLASLKGDVYGLGVVLLEL 236 >6EQI-C nrPDB Length = 433 Score = 32.7 bits (73), Expect = 0.17, Method: Compositional matrix adjust. Identities = 51/188 (27%), Positives = 73/188 (38%), Gaps = 57/188 (30%) Query: 68 HPNVVRLMDVCATSRTD----------------------REIKVTLVFEHVDQDLRTYL- 104 HPN+VR+ V A D R + + LV + D L+ YL Sbjct: 101 HPNIVRMYSVFADRIPDLQCNKQLYPEALPPRINPEGSGRNMSLFLVMKRYDCTLKEYLR 160 Query: 105 DKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGG----TVKLADF 159 DK P + L+ Q L + ++ + I HRDLK +NILV S G T+ + DF Sbjct: 161 DKTPN----MRSSILLLSQLLEAVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDF 216 Query: 160 GLARIYSYQMALTPVVVTLWYR-------------APEVLLQS--TYA----TPVDMWSV 200 G + P YR APE+ T++ D+W+V Sbjct: 217 GCCLCDKQNGLVIP------YRSEDQDKGGNRALMAPEIANAKPGTFSWLNYKKSDLWAV 270 Query: 201 GCIFAEMF 208 G I E+F Sbjct: 271 GAIAYEIF 278 >5UU1-A nrPDB Length = 324 Score = 32.3 bits (72), Expect = 0.25, Method: Compositional matrix adjust. Identities = 19/52 (36%), Positives = 30/52 (57%), Gaps = 2/52 (3%) Query: 116 TIKDLMRQFLRGLDFLHANCIVHRDLKPENILV--TSGGTVKLADFGLARIY 165 T+ L + L L+++H N VH D+K N+L+ + V LAD+GL+ Y Sbjct: 131 TVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRY 182 >2RSV-A nrPDB Length = 403 Score = 32.0 bits (71), Expect = 0.38, Method: Compositional matrix adjust. Identities = 21/77 (27%), Positives = 37/77 (48%), Gaps = 3/77 (3%) Query: 91 LVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTS 150 ++ + DL+ + A +T+ L + L L+++H + VH D+K N+L+ Sbjct: 136 MIMDRFGSDLQKIYE-ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 194 Query: 151 GG--TVKLADFGLARIY 165 V L D+GLA Y Sbjct: 195 KNPDQVYLVDYGLAYRY 211 >5CLR-A nrPDB Length = 451 Score = 31.6 bits (70), Expect = 0.42, Method: Compositional matrix adjust. Identities = 13/30 (43%), Positives = 18/30 (60%) Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFG 160 H ++HRDLKP NI++ + L DFG Sbjct: 192 FHELGLIHRDLKPGNIMLDADMQCHLVDFG 221 >2LAV-A nrPDB Length = 361 Score = 31.6 bits (70), Expect = 0.43, Method: Compositional matrix adjust. Identities = 21/77 (27%), Positives = 37/77 (48%), Gaps = 3/77 (3%) Query: 91 LVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTS 150 ++ + DL+ + A +T+ L + L L+++H + VH D+K N+L+ Sbjct: 129 MIMDRFGSDLQKIYE-ANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNY 187 Query: 151 GG--TVKLADFGLARIY 165 V L D+GLA Y Sbjct: 188 KNPDQVYLVDYGLAYRY 204 >1EU1-A nrPDB Length = 780 Score = 31.2 bits (69), Expect = 0.60, Method: Compositional matrix adjust. Identities = 23/70 (32%), Positives = 30/70 (42%), Gaps = 6/70 (8%) Query: 111 GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPEN---ILVTSG---GTVKLADFGLARI 164 GLPAE I++L R F+ G L A + R E +LVT G + L G Sbjct: 298 GLPAEQIRELARSFVAGRTMLAAGWSIQRMHHGEQAHWMLVTLASMIGQIGLPGGGFGLS 357 Query: 165 YSYQMALTPV 174 Y Y +P Sbjct: 358 YHYSNGGSPT 367 >5DLD-A nrPDB Length = 413 Score = 30.8 bits (68), Expect = 0.70, Method: Compositional matrix adjust. Identities = 38/113 (33%), Positives = 50/113 (44%), Gaps = 19/113 (16%) Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEH---VDQDLRTYLDKAPPPGLPAETIK 118 R EA + +VR + +R D + KV + +H +DQ L + D P L Sbjct: 19 RPEAIKMAPLVRAL----KARADVDAKVCVTAQHRQMLDQVLSLF-DIEPDYDL------ 67 Query: 119 DLMRQFLRGLD----FLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY 167 DLMRQ D LHA V DL+P+ +LV T LA LA Y Y Sbjct: 68 DLMRQGQTLSDVTTGILHAIGAVFDDLRPDIVLVHGDTTTTLA-VSLAAFYRY 119 >4CI6-B nrPDB Length = 643 Score = 30.4 bits (67), Expect = 0.94, Method: Compositional matrix adjust. Identities = 38/151 (25%), Positives = 62/151 (41%), Gaps = 23/151 (15%) Query: 53 TVREVALLRRLEAFEH--------PNVVRLMDVCATSRTDREIKVTLVFEHVD-----QD 99 ++ E L LEA++H PN+ + + +R L+ + VD Sbjct: 78 SIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNR-YYYALLMDEVDGWRCSDT 136 Query: 100 LRTYLDKAPPPGLPAE----TIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTV 154 LR+ D + +E TIK + + L + L IVH D+KP N++ + G Sbjct: 137 LRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEP 196 Query: 155 KLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 + D GL Q P T ++APE+ Sbjct: 197 VVIDLGLHSRSGEQ----PKGFTESFKAPEL 223 >6J6I-B nrPDB Length = 351 Score = 30.0 bits (66), Expect = 1.2, Method: Compositional matrix adjust. Identities = 14/54 (25%), Positives = 26/54 (48%), Gaps = 3/54 (5%) Query: 112 LPAETIKDLMRQFLRGLDFLHA---NCIVHRDLKPENILVTSGGTVKLADFGLA 162 LP + ++ + +LH I+HRD+KP ++ + T KL+D + Sbjct: 160 LPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVKPMHVFLDKNWTAKLSDLSFS 213 >5YPX-A nrPDB Length = 223 Score = 30.0 bits (66), Expect = 1.4, Method: Compositional matrix adjust. Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 5/80 (6%) Query: 94 EHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKP----ENILVT 149 E + Q L+T L K P P E IKDL+ L+ +D H + + +D K E +L+ Sbjct: 137 EEMFQMLKTCLVKQPTEEDPDEGIKDLVEIALKKMDHDHDSRLSKKDFKDAVLIEPLLLE 196 Query: 150 SGGTVKLADFGLARIYSYQM 169 + G L D + I+ Y + Sbjct: 197 AFGKC-LPDEKSSEIFEYHV 215 >4AZV-A nrPDB Length = 569 Score = 29.6 bits (65), Expect = 1.7, Method: Compositional matrix adjust. Identities = 13/43 (30%), Positives = 22/43 (51%) Query: 118 KDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFG 160 + ++ LR L L H D++P N++V + +L DFG Sbjct: 342 EKILGSLLRSLAALEKQGFWHDDVRPWNVMVDARQHARLIDFG 384 >5VE6-A nrPDB Length = 492 Score = 29.3 bits (64), Expect = 2.0, Method: Compositional matrix adjust. Identities = 13/29 (44%), Positives = 19/29 (65%) Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILV 148 L+ Q GL+ L + I+HRDL EN+L+ Sbjct: 213 LLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 >6EWX-A nrPDB Length = 484 Score = 29.3 bits (64), Expect = 2.2, Method: Compositional matrix adjust. Identities = 13/29 (44%), Positives = 19/29 (65%) Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILV 148 L+ Q GL+ L + I+HRDL EN+L+ Sbjct: 215 LLLQLCNGLEHLKEHGIIHRDLCLENLLL 243 >4AZW-A nrPDB Length = 471 Score = 29.3 bits (64), Expect = 2.2, Method: Compositional matrix adjust. Identities = 13/43 (30%), Positives = 22/43 (51%) Query: 118 KDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFG 160 + ++ LR L L H D++P N++V + +L DFG Sbjct: 342 EKILGSLLRSLAALEKKGFWHDDVRPWNVMVDARQHARLIDFG 384 >4LRY-C nrPDB Length = 318 Score = 28.9 bits (63), Expect = 3.0, Method: Compositional matrix adjust. Identities = 12/41 (29%), Positives = 24/41 (58%), Gaps = 2/41 (4%) Query: 171 LTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRK 211 ++P++ T W R +++ + T+ P + G FA ++RRK Sbjct: 12 ISPLIATSWERCNKLMKRETWNVPHQ--AQGVTFASIYRRK 50 >5TX1-A nrPDB Length = 952 Score = 28.9 bits (63), Expect = 3.1, Method: Compositional matrix adjust. Identities = 18/42 (42%), Positives = 23/42 (54%), Gaps = 4/42 (9%) Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKA 107 F +P V DV TDR ++TL F VD++ TYL KA Sbjct: 45 FRNPTVAPTHDVT----TDRSQRLTLRFVPVDREATTYLYKA 82 >5BO0-D nrPDB Length = 158 Score = 28.5 bits (62), Expect = 3.7, Method: Compositional matrix adjust. Identities = 20/93 (21%), Positives = 43/93 (46%), Gaps = 7/93 (7%) Query: 204 FAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPE 263 A+ K ++ G++E+++ +I D + + P V R F + P S++PE Sbjct: 34 LADDLEWKIIYVGSAESEEFDQILDSVLVGP-------VPAGRHMFVFQADAPNPSLIPE 86 Query: 264 MEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 + G ++L T++ + I + + YL+ Sbjct: 87 TDAVGVTVVLITCTYHGQEFIRVGYYVNNEYLN 119 >3QLB-A nrPDB Length = 748 Score = 28.5 bits (62), Expect = 4.2, Method: Compositional matrix adjust. Identities = 15/32 (46%), Positives = 18/32 (56%) Query: 152 GTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183 G V LAD GLA SY + PV+ T +Y P Sbjct: 512 GLVYLADNGLAPYISYSTSFDPVLGTNFYGTP 543 >2XN1-A nrPDB Length = 732 Score = 28.1 bits (61), Expect = 5.2, Method: Compositional matrix adjust. Identities = 27/102 (26%), Positives = 42/102 (41%), Gaps = 1/102 (0%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y E+ T+ + D + F+A KS ++ +G GLP S +E + L Sbjct: 80 YSSAGEMDFHTPATIVRNPDGSNALFLAYKSYKIEDGKPDLKGLPHSWTKEDDEAQTLIV 139 Query: 66 FEHPNVVRL-MDVCATSRTDREIKVTLVFEHVDQDLRTYLDK 106 V +L D+ T DR + V V H + YL+K Sbjct: 140 TLEDKVSKLEYDLLYTIYRDRPVIVRSVQVHNHGEEAVYLEK 181 >2GB3-A nrPDB Length = 409 Score = 28.1 bits (61), Expect = 5.5, Method: Compositional matrix adjust. Identities = 10/14 (71%), Positives = 14/14 (100%) Query: 140 DLKPENILVTSGGT 153 D+KPEN+LVT+GG+ Sbjct: 99 DVKPENVLVTNGGS 112 >3REP-A nrPDB Length = 271 Score = 27.3 bits (59), Expect = 8.4, Method: Compositional matrix adjust. Identities = 41/180 (22%), Positives = 68/180 (37%), Gaps = 16/180 (8%) Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 RL F HPNV+ ++ C + +T + L L + + Sbjct: 60 RLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPY--GSLYNVLHEGTNFVVDQSQAVKFA 117 Query: 122 RQFLRGLDFLHA--NCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTP--VVVT 177 RG+ FLH I L ++++ T +++ + +S+Q +P + Sbjct: 118 LDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVK--FSFQ---SPGRMYAP 172 Query: 178 LWYRAPEVLL---QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 W APE L + T DMWS + E+ R+ F S ++G L GL P Sbjct: 173 AWV-APEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNM-EIGMKVALEGLRP 230 >2ZC0-A nrPDB Length = 407 Score = 26.9 bits (58), Expect = 9.6, Method: Compositional matrix adjust. Identities = 17/53 (32%), Positives = 27/53 (50%), Gaps = 10/53 (18%) Query: 108 PPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFG 160 P G+P +++ + FL+ D H ++ PENI++T GGT L G Sbjct: 73 PANGIP--ELREELAAFLKKYD--------HLEVSPENIVITIGGTGALDLLG 115 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2W96-B nrPDB 419 e-118 1G3N-A nrPDB 377 e-105 2BPM-A nrPDB 325 1e-89 6GU6-A nrPDB 314 4e-86 3NIZ-A nrPDB 312 1e-85 4AU8-A nrPDB 304 2e-83 1V0B-A nrPDB 302 1e-82 4KRC-A nrPDB 299 1e-81 1UA2-A nrPDB 296 6e-81 2F9G-A nrPDB 296 7e-81 5Z33-A nrPDB 294 3e-80 6DTL-A nrPDB 292 1e-79 4QTB-A nrPDB 289 9e-79 5NGU-A nrPDB 289 1e-78 1CM8-A nrPDB 287 3e-78 5EFQ-A nrPDB 287 3e-78 4NST-A nrPDB 287 5e-78 4IC8-A nrPDB 284 3e-77 3OHT-A nrPDB 284 4e-77 4EWQ-A nrPDB 283 7e-77 5AWM-A nrPDB 282 1e-76 1JNK-A nrPDB 282 1e-76 4QNY-A nrPDB 282 1e-76 3FI2-A nrPDB 280 5e-76 4ZSG-A nrPDB 280 5e-76 3E7O-A nrPDB 279 1e-75 4MYG-A nrPDB 278 2e-75 2XS0-A nrPDB 277 4e-75 3GC9-A nrPDB 276 9e-75 5G6V-A nrPDB 275 1e-74 3GC0-A nrPDB 275 2e-74 3OZ6-A nrPDB 275 2e-74 4BBM-A nrPDB 274 2e-74 3NCG-A nrPDB 274 3e-74 5JN2-A nrPDB 274 3e-74 3HZT-A nrPDB 274 4e-74 3MIA-A nrPDB 272 9e-74 4MVF-A nrPDB 272 1e-73 3DFA-A nrPDB 272 2e-73 3DXN-A nrPDB 272 2e-73 4AGU-A nrPDB 271 2e-73 3LIJ-A nrPDB 269 8e-73 3PG1-A nrPDB 269 9e-73 3MA6-A nrPDB 267 3e-72 4BGQ-A nrPDB 266 7e-72 3N9X-A nrPDB 265 2e-71 4YZB-A nrPDB 264 5e-71 2BDW-A nrPDB 263 7e-71 2VN9-A nrPDB 262 1e-70 3RP9-A nrPDB 262 2e-70 5FG8-A nrPDB 262 2e-70 3KK8-A nrPDB 260 5e-70 5AIR-A nrPDB 260 7e-70 4O2Z-A nrPDB 259 1e-69 2V7O-A nrPDB 258 2e-69 3COM-A nrPDB 258 2e-69 3NIE-A nrPDB 258 2e-69 5U6Y-A nrPDB 257 4e-69 3MN3-A nrPDB 256 1e-68 4E7W-A nrPDB 255 1e-68 4RGJ-A nrPDB 255 1e-68 3BHH-A nrPDB 255 2e-68 2VZ6-A nrPDB 255 2e-68 5Y86-A nrPDB 254 3e-68 3ZDU-A nrPDB 254 3e-68 4FG9-A nrPDB 254 4e-68 5IG1-A nrPDB 254 4e-68 3Q5I-A nrPDB 253 7e-68 4REW-A nrPDB 253 9e-68 3TAC-A nrPDB 252 9e-68 2JC6-A nrPDB 252 1e-67 4LG4-A nrPDB 251 2e-67 3SOA-A nrPDB 251 3e-67 6AO5-A nrPDB 249 1e-66 4CFH-A nrPDB 248 3e-66 5YKS-A nrPDB 247 3e-66 2J90-A nrPDB 247 3e-66 4RED-A nrPDB 247 4e-66 4CFF-A nrPDB 247 5e-66 3E3P-A nrPDB 247 6e-66 5ZTN-A nrPDB 246 7e-66 5EZV-A nrPDB 246 9e-66 2Y7J-A nrPDB 246 9e-66 2I6L-A nrPDB 246 9e-66 4UZD-A nrPDB 245 1e-65 4NIF-A nrPDB 245 1e-65 3H4J-B nrPDB 245 1e-65 3D2K-A nrPDB 245 2e-65 2YAB-A nrPDB 244 2e-65 5XZW-A nrPDB 244 3e-65 4CZT-A nrPDB 242 1e-64 1PHK-A nrPDB 242 1e-64 3GUB-A nrPDB 242 1e-64 2YCR-A nrPDB 242 2e-64 3EB0-A nrPDB 241 3e-64 2YZA-A nrPDB 241 4e-64 5D7A-A nrPDB 240 4e-64 2W4O-A nrPDB 240 6e-64 5ES1-A nrPDB 240 7e-64 2A27-A nrPDB 239 8e-64 1ZWS-A nrPDB 239 2e-63 3I6U-A nrPDB 239 2e-63 2JAM-A nrPDB 239 2e-63 5JZN-A nrPDB 238 2e-63 1NY3-A nrPDB 236 8e-63 4JG6-A nrPDB 236 9e-63 4KS7-A nrPDB 236 9e-63 2QNJ-A nrPDB 236 9e-63 6FD3-A nrPDB 236 1e-62 3KA0-A nrPDB 235 1e-62 2UV2-A nrPDB 235 1e-62 2OZA-A nrPDB 235 2e-62 4PDS-A nrPDB 235 2e-62 5WAX-A nrPDB 235 2e-62 3F3Z-A nrPDB 234 3e-62 5KZ7-A nrPDB 234 4e-62 3FXW-A nrPDB 233 6e-62 2F57-A nrPDB 233 9e-62 3IS5-A nrPDB 232 1e-61 4D28-A nrPDB 232 1e-61 4QMW-A nrPDB 232 2e-61 4FIE-A nrPDB 231 2e-61 3UTO-A nrPDB 231 3e-61 4CSV-A nrPDB 231 3e-61 2X4F-A nrPDB 230 5e-61 2WO6-A nrPDB 230 5e-61 2XIK-A nrPDB 230 7e-61 4CQG-A nrPDB 230 7e-61 6FYV-A nrPDB 229 9e-61 4D2V-A nrPDB 229 9e-61 4JDH-A nrPDB 229 1e-60 3RAW-A nrPDB 229 1e-60 4XBR-A nrPDB 229 1e-60 1KOA-A nrPDB 229 1e-60 2Q0N-A nrPDB 229 1e-60 4JXF-A nrPDB 229 1e-60 5J5T-A nrPDB 229 2e-60 3UC3-A nrPDB 229 2e-60 5X8I-B nrPDB 228 2e-60 4FZF-B nrPDB 228 3e-60 1FOT-A nrPDB 228 3e-60 6HXF-B nrPDB 228 3e-60 4B6L-A nrPDB 227 5e-60 4L42-A nrPDB 227 6e-60 1KOB-A nrPDB 227 6e-60 3ZUT-A nrPDB 227 7e-60 4U41-A nrPDB 227 7e-60 5KCV-A nrPDB 226 8e-60 3Q53-A nrPDB 226 1e-59 6FDY-U nrPDB 226 1e-59 2JDO-A nrPDB 225 1e-59 4I6B-A nrPDB 225 2e-59 3TXO-A nrPDB 225 2e-59 4RLP-A nrPDB 225 2e-59 3MV5-A nrPDB 225 2e-59 3UDB-A nrPDB 225 3e-59 5UNP-A nrPDB 224 5e-59 6O6Q-A nrPDB 223 8e-59 4APC-A nrPDB 223 8e-59 5D9K-A nrPDB 222 1e-58 3HDN-A nrPDB 222 2e-58 2Z7Q-A nrPDB 221 3e-58 2HW6-A nrPDB 220 4e-58 5F9E-A nrPDB 220 4e-58 6CMJ-A nrPDB 220 4e-58 6C9D-A nrPDB 220 8e-58 2HAK-A nrPDB 219 9e-58 3DAK-A nrPDB 219 1e-57 4B8L-A nrPDB 218 2e-57 3LM0-A nrPDB 217 4e-57 5XVU-A nrPDB 217 5e-57 3DB8-A nrPDB 217 5e-57 5N23-A nrPDB 217 5e-57 4CRL-A nrPDB 216 8e-57 4MD7-E nrPDB 216 8e-57 5X3F-B nrPDB 216 1e-56 3HKO-A nrPDB 215 2e-56 4WNO-A nrPDB 215 2e-56 2OU7-A nrPDB 215 2e-56 4AF3-A nrPDB 215 2e-56 1VZO-A nrPDB 215 3e-56 3KN6-A nrPDB 214 4e-56 6ED6-A nrPDB 214 4e-56 4WB7-A nrPDB 214 4e-56 5DBX-A nrPDB 214 4e-56 1U5R-A nrPDB 214 4e-56 4YNZ-A nrPDB 214 4e-56 4J52-A nrPDB 213 5e-56 2WQN-A nrPDB 213 6e-56 6CKI-A nrPDB 213 9e-56 5LOH-A nrPDB 213 9e-56 2GCD-A nrPDB 213 1e-55 5YV8-A nrPDB 212 1e-55 6QAU-A nrPDB 212 2e-55 3NYO-A nrPDB 212 2e-55 2PVN-A nrPDB 212 2e-55 3A8W-A nrPDB 211 3e-55 6CQF-A nrPDB 211 3e-55 6E9W-A nrPDB 211 3e-55 6EII-A nrPDB 211 3e-55 5DYK-A nrPDB 210 5e-55 4RA4-A nrPDB 210 7e-55 6HMD-A nrPDB 210 8e-55 5MJB-A nrPDB 209 9e-55 5L6P-A nrPDB 208 2e-54 4GS6-A nrPDB 208 2e-54 5FET-A nrPDB 208 2e-54 2H8H-A nrPDB 208 3e-54 3ORZ-A nrPDB 207 4e-54 2FO0-A nrPDB 206 9e-54 2WTK-C nrPDB 206 9e-54 6F3F-A nrPDB 206 1e-53 4EBW-A nrPDB 206 1e-53 2DQ7-X nrPDB 205 1e-53 4XEY-B nrPDB 205 1e-53 4P5Q-A nrPDB 205 2e-53 2VWV-A nrPDB 205 2e-53 1TKI-A nrPDB 205 2e-53 4C0T-A nrPDB 205 3e-53 6BDL-A nrPDB 204 3e-53 2XNP-A nrPDB 204 3e-53 3VN9-A nrPDB 204 3e-53 4FR4-A nrPDB 204 3e-53 1JPA-A nrPDB 204 3e-53 4TNB-A nrPDB 204 4e-53 2Y6O-A nrPDB 204 5e-53 2X7G-A nrPDB 203 5e-53 2JD5-A nrPDB 203 6e-53 6NPU-A nrPDB 203 7e-53 4E93-A nrPDB 203 9e-53 3PFQ-A nrPDB 203 9e-53 2BRG-A nrPDB 203 1e-52 3M42-A nrPDB 202 1e-52 2J0K-A nrPDB 202 1e-52 6E2O-A nrPDB 202 1e-52 3DKO-A nrPDB 202 2e-52 2R2P-A nrPDB 202 2e-52 2XYN-A nrPDB 201 3e-52 5SYS-A nrPDB 201 3e-52 4IAN-A nrPDB 201 3e-52 4KIK-B nrPDB 201 4e-52 6CCF-A nrPDB 201 4e-52 3TKU-A nrPDB 200 4e-52 2I0E-A nrPDB 200 4e-52 4WUA-A nrPDB 200 4e-52 3FME-A nrPDB 200 5e-52 3ALO-A nrPDB 200 7e-52 5H2U-A nrPDB 200 9e-52 5KKR-C nrPDB 198 2e-51 6BXI-A nrPDB 198 2e-51 4LQP-A nrPDB 198 2e-51 4AW2-A nrPDB 198 2e-51 4UYA-A nrPDB 198 3e-51 4AN9-A nrPDB 198 3e-51 5VO2-A nrPDB 198 3e-51 1FVR-A nrPDB 197 4e-51 3ORP-A nrPDB 197 4e-51 3PPZ-A nrPDB 197 6e-51 4LFI-A nrPDB 197 7e-51 4OTD-A nrPDB 196 1e-50 3EQC-A nrPDB 196 1e-50 5X5O-A nrPDB 196 1e-50 4UY9-A nrPDB 195 2e-50 4YHJ-A nrPDB 195 2e-50 5TQX-A nrPDB 194 3e-50 4PDO-A nrPDB 194 3e-50 3V5Q-A nrPDB 194 4e-50 2VD5-A nrPDB 193 5e-50 6DBN-A nrPDB 193 5e-50 3A4O-X nrPDB 193 5e-50 3DTC-A nrPDB 193 6e-50 2A1A-B nrPDB 193 8e-50 3LLT-A nrPDB 193 9e-50 4XCU-A nrPDB 193 1e-49 4XLV-A nrPDB 193 1e-49 4EQM-A nrPDB 193 1e-49 4OLI-A nrPDB 192 1e-49 6GQK-A nrPDB 192 2e-49 3KUL-B nrPDB 192 2e-49 1LUF-A nrPDB 192 2e-49 3C51-A nrPDB 191 3e-49 3QGY-A nrPDB 191 3e-49 3QA8-A nrPDB 191 3e-49 3TT0-A nrPDB 191 3e-49 3DLS-A nrPDB 191 4e-49 6DBM-A nrPDB 190 5e-49 6GVJ-A nrPDB 190 6e-49 4AT3-A nrPDB 190 6e-49 2PL0-A nrPDB 190 7e-49 5A46-A nrPDB 190 7e-49 5O2B-A nrPDB 189 9e-49 5TOS-A nrPDB 189 1e-48 5O2C-A nrPDB 189 1e-48 4K33-A nrPDB 189 1e-48 4E20-A nrPDB 189 1e-48 3KRL-A nrPDB 189 1e-48 4CRS-A nrPDB 189 1e-48 3GQL-A nrPDB 189 1e-48 2OGV-A nrPDB 188 2e-48 4PWN-A nrPDB 188 2e-48 2PSQ-A nrPDB 188 2e-48 1K9A-A nrPDB 188 3e-48 5KMM-A nrPDB 188 3e-48 5UUU-A nrPDB 188 3e-48 1S9I-A nrPDB 188 3e-48 3UIU-A nrPDB 188 3e-48 3BEA-A nrPDB 188 3e-48 4M7I-A nrPDB 187 4e-48 3PVW-A nrPDB 187 5e-48 4H1J-A nrPDB 187 6e-48 6FEX-A nrPDB 187 6e-48 2HK5-A nrPDB 186 9e-48 4HVI-A nrPDB 186 9e-48 6BSD-A nrPDB 186 9e-48 6FER-A nrPDB 186 1e-47 3HMP-A nrPDB 186 1e-47 1ZXE-A nrPDB 185 1e-47 3BBT-B nrPDB 185 2e-47 3QUP-A nrPDB 185 2e-47 1BYG-A nrPDB 185 3e-47 4XUF-A nrPDB 184 5e-47 3ZBF-A nrPDB 183 6e-47 4R7H-A nrPDB 183 7e-47 5AP3-A nrPDB 183 7e-47 2ZMD-A nrPDB 183 8e-47 1AD5-A nrPDB 183 8e-47 5HI2-A nrPDB 183 8e-47 5X02-A nrPDB 183 9e-47 5EG3-A nrPDB 183 1e-46 5B2L-A nrPDB 183 1e-46 3SXS-A nrPDB 182 1e-46 3CJF-A nrPDB 182 1e-46 4HZS-A nrPDB 182 2e-46 5VD3-A nrPDB 182 2e-46 2W1I-A nrPDB 182 2e-46 5HVK-A nrPDB 182 3e-46 3IO7-A nrPDB 181 3e-46 5U6B-A nrPDB 181 3e-46 4Y93-A nrPDB 181 4e-46 4LRM-A nrPDB 180 5e-46 1U54-B nrPDB 180 5e-46 3G0E-A nrPDB 180 6e-46 3OMV-A nrPDB 180 7e-46 3ZZW-A nrPDB 180 8e-46 4XI2-A nrPDB 180 8e-46 5AMN-A nrPDB 179 2e-45 6E4F-A nrPDB 178 2e-45 4OW8-A nrPDB 178 3e-45 4X3F-A nrPDB 178 3e-45 4C59-A nrPDB 178 3e-45 6B2Q-A nrPDB 178 3e-45 5GRN-A nrPDB 177 4e-45 5GNK-A nrPDB 177 5e-45 5HIE-A nrPDB 177 7e-45 3I81-A nrPDB 177 8e-45 3LZB-A nrPDB 176 9e-45 5U6C-A nrPDB 176 9e-45 5O0Y-A nrPDB 176 1e-44 3PP0-A nrPDB 176 1e-44 6CTH-A nrPDB 176 1e-44 1U59-A nrPDB 175 1e-44 2OZO-A nrPDB 175 2e-44 4IDT-A nrPDB 175 2e-44 2BUJ-A nrPDB 175 3e-44 4X7Q-B nrPDB 174 3e-44 4YFF-A nrPDB 174 4e-44 5FM2-A nrPDB 174 4e-44 6J5U-C nrPDB 173 6e-44 3PLS-A nrPDB 172 1e-43 5HLW-A nrPDB 172 2e-43 3Q4U-A nrPDB 172 2e-43 5TUR-A nrPDB 172 3e-43 4Y83-A nrPDB 171 3e-43 3C1X-A nrPDB 171 3e-43 4TPT-A nrPDB 171 3e-43 3BGP-A nrPDB 170 6e-43 5LPZ-A nrPDB 169 1e-42 2QKW-B nrPDB 169 1e-42 4RC3-A nrPDB 169 1e-42 5UIU-A nrPDB 168 2e-42 5LPV-A nrPDB 168 2e-42 3MY0-A nrPDB 168 2e-42 6HV0-A nrPDB 168 2e-42 2PMN-X nrPDB 168 3e-42 4FL3-A nrPDB 167 4e-42 3MDY-A nrPDB 167 6e-42 3QD2-B nrPDB 167 6e-42 5IKW-A nrPDB 167 7e-42 2WTK-B nrPDB 167 7e-42 2RIO-A nrPDB 166 1e-41 4PL5-B nrPDB 166 1e-41 5WNL-A nrPDB 165 3e-41 3AOX-A nrPDB 165 3e-41 4NEU-A nrPDB 164 3e-41 1PY5-A nrPDB 163 6e-41 5TE0-A nrPDB 163 6e-41 5C26-A nrPDB 163 8e-41 4G3E-A nrPDB 162 1e-40 4JLC-A nrPDB 162 2e-40 4EUU-A nrPDB 162 2e-40 3UIM-A nrPDB 161 2e-40 4F0G-A nrPDB 161 2e-40 4EUT-A nrPDB 160 5e-40 5WNO-A nrPDB 160 5e-40 3G2F-A nrPDB 158 2e-39 6O8B-A nrPDB 158 3e-39 6NT9-A nrPDB 158 3e-39 3LMG-A nrPDB 156 1e-38 5XD6-A nrPDB 155 3e-38 2H34-A nrPDB 151 3e-37 6BFN-A nrPDB 146 8e-36 3SOC-A nrPDB 146 8e-36 4M66-A nrPDB 146 9e-36 5E8V-A nrPDB 143 6e-35 4F9B-A nrPDB 143 7e-35 2PZI-A nrPDB 141 4e-34 4Y12-A nrPDB 141 4e-34 4MWI-A nrPDB 139 2e-33 2Y4I-B nrPDB 139 2e-33 3HNG-A nrPDB 135 2e-32 5VC6-A nrPDB 134 4e-32 4M69-B nrPDB 134 5e-32 3VHK-A nrPDB 133 6e-32 4BTF-A nrPDB 133 7e-32 2QLU-A nrPDB 133 7e-32 4BTK-A nrPDB 133 8e-32 4NFN-A nrPDB 132 2e-31 5VDK-A nrPDB 131 3e-31 4JRN-A nrPDB 129 2e-30 4RT7-A nrPDB 124 5e-29 5M07-A nrPDB 119 1e-27 3SV0-A nrPDB 119 2e-27 5OAT-A nrPDB 117 5e-27 5FQD-C nrPDB 115 2e-26 4TN6-A nrPDB 114 5e-26 2C47-A nrPDB 107 6e-24 4NT4-A nrPDB 107 7e-24 2CMW-A nrPDB 104 4e-23 4XHH-A nrPDB 96 2e-20 4XHL-A nrPDB 95 4e-20 4IX6-A nrPDB 78 5e-15 Sequences not found previously or not previously below threshold: 5AR8-A nrPDB 137 7e-33 5L2Q-C nrPDB 130 8e-31 5J0A-A nrPDB 129 2e-30 6DC0-A nrPDB 123 8e-29 5CEK-A nrPDB 123 9e-29 5X1R-A nrPDB 122 2e-28 5X18-A nrPDB 110 8e-25 3REP-A nrPDB 108 4e-24 2CHL-A nrPDB 106 2e-23 6EQI-C nrPDB 103 8e-23 4L00-A nrPDB 102 2e-22 1CSN-A nrPDB 100 8e-22 4L68-A nrPDB 100 8e-22 6J6I-B nrPDB 98 4e-21 5UV4-A nrPDB 97 1e-20 5USZ-A nrPDB 95 4e-20 5C01-A nrPDB 94 8e-20 4WOV-A nrPDB 93 1e-19 4I94-A nrPDB 92 4e-19 5UU1-A nrPDB 82 2e-16 2RSV-A nrPDB 80 9e-16 5CLR-A nrPDB 80 1e-15 2LAV-A nrPDB 79 2e-15 6EAS-A nrPDB 72 4e-13 5DMZ-A nrPDB 71 4e-13 4CI6-B nrPDB 70 1e-12 2JII-A nrPDB 65 6e-11 4O1O-A nrPDB 62 3e-10 6G4J-A nrPDB 62 3e-10 4CYJ-A nrPDB 61 4e-10 6BHC-A nrPDB 61 6e-10 6EWX-A nrPDB 59 2e-09 6M7Z-A nrPDB 58 6e-09 4OAU-C nrPDB 58 7e-09 5GZ9-A nrPDB 52 3e-07 4AZV-A nrPDB 51 6e-07 4AZW-A nrPDB 51 8e-07 6G38-A nrPDB 49 3e-06 4BWP-A nrPDB 49 3e-06 3Q60-A nrPDB 48 4e-06 5GZA-A nrPDB 48 5e-06 3BYV-A nrPDB 48 6e-06 3ENH-A nrPDB 48 7e-06 4CZY-B nrPDB 47 1e-05 5VE6-A nrPDB 46 2e-05 4WWA-A nrPDB 46 2e-05 3DZO-A nrPDB 43 2e-04 2W1Z-A nrPDB 43 2e-04 5YK0-A nrPDB 41 7e-04 6G18-v nrPDB 39 0.003 6FDN-A nrPDB 37 0.010 6DFL-A nrPDB 36 0.029 1TQM-A nrPDB 34 0.059 6FAI-l nrPDB 33 0.19 5JY7-I nrPDB 33 0.19 4ESA-B nrPDB 31 0.51 5FBM-A nrPDB 31 0.68 3TYK-A nrPDB 31 0.91 4BVU-A nrPDB 30 1.4 >2W96-B nrPDB Length = 306 Score = 419 bits (1077), Expect = e-118, Method: Composition-based stats. Identities = 297/303 (98%), Positives = 297/303 (98%), Gaps = 3/303 (0%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNG GLPISTVREVALL Sbjct: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGE---EGLPISTVREVALL 57 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL Sbjct: 58 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 117 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY 180 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL PVVVTLWY Sbjct: 118 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALDPVVVTLWY 177 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR Sbjct: 178 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 237 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 300 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG Sbjct: 238 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 297 Query: 301 NPE 303 NPE Sbjct: 298 NPE 300 >1G3N-A nrPDB Length = 326 Score = 377 bits (969), Expect = e-105, Method: Composition-based stats. Identities = 211/303 (69%), Positives = 243/303 (80%), Gaps = 4/303 (1%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARD-PHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 A +YE VAEIG GAYG V+KARD + G FVALK VRV G G+P+ST+REVA+L Sbjct: 9 ADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRV---QTGEEGMPLSTIREVAVL 65 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 R LE FEHPNVVRL DVC SRTDRE K+TLVFEHVDQDL TYLDK P PG+P ETIKD+ Sbjct: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDM 125 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY 180 M Q LRGLDFLH++ +VHRDLKP+NILVTS G +KLADFGLARIYS+QMALT VVVTLWY Sbjct: 126 MFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWY 185 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 RAPEVLLQS+YATPVD+WSVGCIFAEMFRRKPLF G+S+ DQLGKI D+IGLP E+DWPR Sbjct: 186 RAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPR 245 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 300 DV+LPR AF + +P++ V +++E G LLL+ LTFNP KRISA+ AL H Y E Sbjct: 246 DVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLER 305 Query: 301 NPE 303 E Sbjct: 306 CKE 308 >2BPM-A nrPDB Length = 309 Score = 325 bits (834), Expect = 1e-89, Method: Composition-based stats. Identities = 134/299 (44%), Positives = 187/299 (62%), Gaps = 15/299 (5%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 ++ V +IG G YG VYKAR+ +G VALK +R+ G+P + +RE++LL+ Sbjct: 6 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLD---TETEGVPSTAIREISLLKE 62 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L HPN+V+L+DV T E K+ LVFE + QDL+ ++D + G+P IK + Sbjct: 63 L---NHPNIVKLLDVIHT-----ENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLF 114 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-LTPVVVTLWYR 181 Q L+GL F H++ ++HRDLKP+N+L+ + G +KLADFGLAR + + T VVTLWYR Sbjct: 115 QLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYR 174 Query: 182 APEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 APE+LL Y+T VD+WS+GCIFAEM R+ LF G+SE DQL +IF +G P E WP Sbjct: 175 APEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPG 234 Query: 241 DVSLPRGA--FPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 S+P FP + VVP ++E G LL +ML ++P+KRISA AL H + Sbjct: 235 VTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQD 293 >6GU6-A nrPDB Length = 302 Score = 314 bits (804), Expect = 4e-86, Method: Composition-based stats. Identities = 128/304 (42%), Positives = 185/304 (60%), Gaps = 16/304 (5%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 + Y + +IG G YG VYK R +G VA+K +R+ + G+P + +RE++LL+ Sbjct: 5 SMEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEE---EGVPSTAIREISLLK 61 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPP-PGLPAETIKDL 120 L HPN+V L DV ++ ++ L+FE + DL+ YLD PP + + +K Sbjct: 62 ELR---HPNIVSLQDVLM-----QDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSY 113 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-LTPVVVTLW 179 + Q L+G+ F H+ ++HRDLKP+N+L+ GT+KLADFGLAR + + T VVTLW Sbjct: 114 LYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLW 173 Query: 180 YRAPEVLLQS-TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 YR+PEVLL S Y+TPVD+WS+G IFAE+ +KPLF G+SE DQL +IF +G P + W Sbjct: 174 YRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVW 233 Query: 239 PRDVSL--PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 P SL + FP P + S V ++E+G LL +ML ++P KRIS AL H Y + Sbjct: 234 PEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFN 293 Query: 297 KDEG 300 + Sbjct: 294 DLDN 297 >3NIZ-A nrPDB Length = 311 Score = 312 bits (799), Expect = 1e-85, Method: Composition-based stats. Identities = 130/302 (43%), Positives = 183/302 (60%), Gaps = 18/302 (5%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 +Y+ + ++G G YG VYKA+D G VALK +R+ G+P + +RE++LL+ Sbjct: 20 MEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLD---AEDEGIPSTAIREISLLKE 75 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L HPN+V L+DV + R +TLVFE +++DL+ LD+ GL IK + Sbjct: 76 L---HHPNIVSLIDVIHSER-----CLTLVFEFMEKDLKKVLDENK-TGLQDSQIKIYLY 126 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS-YQMALTPVVVTLWYR 181 Q LRG+ H + I+HRDLKP+N+L+ S G +KLADFGLAR + + T VVTLWYR Sbjct: 127 QLLRGVAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYR 186 Query: 182 APEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 AP+VL+ Y+T VD+WS+GCIFAEM KPLF G ++ DQL KIF ++G P +WP+ Sbjct: 187 APDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQ 246 Query: 241 DVSLP---RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 LP + F +P S++P + G LL ML F+P+KRISA A+ H Y Sbjct: 247 VQELPLWKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKD 306 Query: 298 DE 299 + Sbjct: 307 LD 308 >4AU8-A nrPDB Length = 296 Score = 304 bits (780), Expect = 2e-83, Method: Composition-based stats. Identities = 132/302 (43%), Positives = 178/302 (58%), Gaps = 17/302 (5%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 M + +YE + +IG G YGTV+KA++ + VALK VR+ G+P S +RE+ LL Sbjct: 3 MGSQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLD---DDDEGVPSSALREICLL 59 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 + L+ H N+VRL DV + + K+TLVFE DQDL+ Y D L E +K Sbjct: 60 KELK---HKNIVRLHDVLHSDK-----KLTLVFEFCDQDLKKYFDSCNG-DLDPEIVKSF 110 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS-YQMALTPVVVTLW 179 + Q L+GL F H+ ++HRDLKP+N+L+ G +KLADFGLAR + + VVTLW Sbjct: 111 LFQLLKGLGFCHSRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLW 170 Query: 180 YRAPEVLLQST-YATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDD 237 YR P+VL + Y+T +DMWS GCIFAE+ +PLF GN DQL +IF L+G P E+ Sbjct: 171 YRPPDVLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQ 230 Query: 238 WPRDVSLPRGAFPPRGPRPVQ--SVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 WP LP P P +VVP++ +G LL +L NP +RISA ALQH Y Sbjct: 231 WPSMTKLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 290 Query: 296 HK 297 Sbjct: 291 SD 292 >1V0B-A nrPDB Length = 288 Score = 302 bits (774), Expect = 1e-82, Method: Composition-based stats. Identities = 127/301 (42%), Positives = 186/301 (61%), Gaps = 17/301 (5%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 +Y + +IG G YG VYKA++ + G ALK +R+ G+P +T+RE+++L+ Sbjct: 1 MEKYHGLEKIGEGTYGVVYKAQN-NYGETFALKKIRLEKE---DEGIPSTTIREISILKE 56 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L+ H N+V+L DV T + ++ LVFEH+DQDL+ LD GL + T K + Sbjct: 57 LK---HSNIVKLYDVIHTKK-----RLVLVFEHLDQDLKKLLDVCEG-GLESVTAKSFLL 107 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS-YQMALTPVVVTLWYR 181 Q L G+ + H ++HRDLKP+N+L+ G +K+ADFGLAR + T VVTLWYR Sbjct: 108 QLLNGIAYCHDRRVLHRDLKPQNLLINREGELKIADFGLARAFGIPVRKYTHEVVTLWYR 167 Query: 182 APEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 AP+VL+ Y+T +D+WSVGCIFAEM PLF G SEADQL +IF ++G P +WP Sbjct: 168 APDVLMGSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPN 227 Query: 241 DVSLPRG--AFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 LP+ F P P +S + ++ESG LL +ML +P++RI+A +AL+H+Y ++ Sbjct: 228 VTELPKYDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKEN 287 Query: 299 E 299 Sbjct: 288 N 288 >4KRC-A nrPDB Length = 317 Score = 299 bits (766), Expect = 1e-81, Method: Composition-based stats. Identities = 123/309 (39%), Positives = 181/309 (58%), Gaps = 25/309 (8%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 ++S+++ + ++G G Y TVYK + +G +VALK V++ + G P + +RE++L++ Sbjct: 3 SSSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLDSEEGT----PSTAIREISLMK 58 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAP----PPGLPAETI 117 L+ H N+VRL DV T E K+TLVFE +D DL+ Y+D P GL + Sbjct: 59 ELK---HENIVRLYDVIHT-----ENKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLV 110 Query: 118 KDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-LTPVVV 176 K Q L+GL F H N I+HRDLKP+N+L+ G +KL DFGLAR + + + VV Sbjct: 111 KYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVNTFSSEVV 170 Query: 177 TLWYRAPEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPE 235 TLWYRAP+VL+ TY+T +D+WS GCI AEM KPLF G ++ +QL IFD++G P E Sbjct: 171 TLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNE 230 Query: 236 DDWPRDVSLPRG--AFPPRGPRPVQSVV-----PEMEESGAQLLLEMLTFNPHKRISAFR 288 WP LP+ R PR ++ V+ ++ + L +L NP R+SA + Sbjct: 231 SLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQ 290 Query: 289 ALQHSYLHK 297 AL H + + Sbjct: 291 ALHHPWFAE 299 >1UA2-A nrPDB Length = 346 Score = 296 bits (759), Expect = 6e-81, Method: Composition-based stats. Identities = 113/301 (37%), Positives = 164/301 (54%), Gaps = 12/301 (3%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 RYE + +G G + TVYKARD ++ VA+K +++ + G+ + +RE+ LL+ Sbjct: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L HPN++ L+D ++LVF+ ++ DL + K L IK M Sbjct: 69 LS---HPNIIGLLDAFGHKSN-----ISLVFDFMETDL-EVIIKDNSLVLTPSHIKAYML 119 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-SYQMALTPVVVTLWYR 181 L+GL++LH + I+HRDLKP N+L+ G +KLADFGLA+ + S A T VVT WYR Sbjct: 120 MTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYR 179 Query: 182 APEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 APE+L Y VDMW+VGCI AE+ R P G+S+ DQL +IF+ +G P E+ WP Sbjct: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239 Query: 241 DVSLPRG-AFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE 299 SLP F P+ + + L+ + FNP RI+A +AL+ Y Sbjct: 240 MCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRP 299 Query: 300 G 300 G Sbjct: 300 G 300 >2F9G-A nrPDB Length = 353 Score = 296 bits (758), Expect = 7e-81, Method: Composition-based stats. Identities = 107/321 (33%), Positives = 162/321 (50%), Gaps = 30/321 (9%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 +S ++ + +G GAYG V A +G VA+K + + T+RE+ +L+ Sbjct: 10 SSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKI----EPFDKPLFALRTLREIKILKH 65 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 F+H N++ + ++ + +V ++ E + DL + L + I+ + Sbjct: 66 ---FKHENIITIFNIQRPDSFENFNEVYIIQELMQTDLHRVISTQM---LSDDHIQYFIY 119 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY-----------QMAL 171 Q LR + LH + ++HRDLKP N+L+ S +K+ DFGLARI Q + Sbjct: 120 QTLRAVKVLHGSNVIHRDLKPSNLLINSNCDLKVCDFGLARIIDESAADNSEPTGQQSGM 179 Query: 172 TPVVVTLWYRAPEVLLQS-TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLI 230 T V T WYRAPEV+L S Y+ +D+WS GCI AE+F R+P+F G QL IF +I Sbjct: 180 TEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGII 239 Query: 231 GLPPEDDWPRDVSLPR-----GAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 G P D+ R + PR + P P++ + P + G LL ML F+P KRI+ Sbjct: 240 GTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKRIT 299 Query: 286 AFRALQHSYL---HKDEGNPE 303 A AL+H YL H PE Sbjct: 300 AKEALEHPYLQTYHDPNDEPE 320 >5Z33-A nrPDB Length = 425 Score = 294 bits (753), Expect = 3e-80, Method: Composition-based stats. Identities = 104/316 (32%), Positives = 148/316 (46%), Gaps = 21/316 (6%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + RY E+G GAYG V A + + VA+K V L +RE+ LL Sbjct: 28 IVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKV---TNVFSKKILAKRALREIKLL 84 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 + H N+ L D R D + L E ++ DL + P L + Sbjct: 85 QHFRG--HRNITCLYD-MDIPRPDNFNETYLYEELMECDLAAIIRSGQP--LTDAHFQSF 139 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ-----MALTPVV 175 + Q L GL ++H+ ++HRDLKP N+LV + +K+ DFGLAR +S +T V Sbjct: 140 IYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPEENAGYMTEYV 199 Query: 176 VTLWYRAPEV-LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 T WYRAPE+ L +Y +D+WSVGCI AE+ +P F G DQL +I ++G P Sbjct: 200 ATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPN 259 Query: 235 EDDWPRDVSLPRGAF----PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRAL 290 E+ R S + P +P ++ P LL ML F+P RIS +AL Sbjct: 260 EETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQAL 319 Query: 291 QHSYL---HKDEGNPE 303 +H YL H P+ Sbjct: 320 EHPYLHIWHDASDEPD 335 >6DTL-A nrPDB Length = 364 Score = 292 bits (747), Expect = 1e-79, Method: Composition-based stats. Identities = 110/310 (35%), Positives = 161/310 (51%), Gaps = 16/310 (5%) Query: 2 ATSRYEP-VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 T++Y+P + IG GAYG V A + + VA+K + T+RE+ LL Sbjct: 27 VTAKYKPPIMPIGKGAYGIVCSAMNSETNESVAIKKIANAFDNKIDA---KRTLREIKLL 83 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 R + +H N+V + D+ + V + +E +D DL + L E + Sbjct: 84 RHM---DHENIVAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSN--QALSEEHCQYF 138 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY 180 + Q LRGL ++H+ ++HRDLKP N+L+ + +K+ DFGLAR+ S +T VVT WY Sbjct: 139 LYQILRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARVTSESDFMTEYVVTRWY 198 Query: 181 RAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 RAPE+LL S+ Y +D+WSVGCIF E+ RKPLF G QL + +LIG P E++ Sbjct: 199 RAPELLLNSSDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELE 258 Query: 240 RDVSLPRGAFPPRGPRPVQSV---VPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY-- 294 + P P QS+ P + L+ +MLTF+P +RI+ AL H Y Sbjct: 259 FLNENAKRYIRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLN 318 Query: 295 -LHKDEGNPE 303 LH PE Sbjct: 319 SLHDISDEPE 328 >4QTB-A nrPDB Length = 380 Score = 289 bits (740), Expect = 9e-79, Method: Composition-based stats. Identities = 104/305 (34%), Positives = 152/305 (49%), Gaps = 19/305 (6%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 RY + IG GAYG V A D VA+K + T+RE+ +L R Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI----SPFEHQTYCQRTLREIQILLR-- 95 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 F H NV+ + D+ S + V +V + ++ DL L L + I + Q Sbjct: 96 -FRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQ---LSNDHICYFLYQI 151 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI----YSYQMALTPVVVTLWY 180 LRGL ++H+ ++HRDLKP N+L+ + +K+ DFGLARI + + LT V T WY Sbjct: 152 LRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWY 211 Query: 181 RAPEV-LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 RAPE+ L Y +D+WSVGCI AEM +P+F G DQL I ++G P ++D Sbjct: 212 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 271 Query: 240 RDVSLPRGAF----PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 +++ + P + + P+ + LL MLTFNP+KRI+ AL H YL Sbjct: 272 CIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYL 331 Query: 296 HKDEG 300 + Sbjct: 332 EQYYD 336 >5NGU-A nrPDB Length = 381 Score = 289 bits (740), Expect = 1e-78, Method: Composition-based stats. Identities = 104/305 (34%), Positives = 153/305 (50%), Gaps = 19/305 (6%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 RY ++ IG GAYG V A D + VA+K + T+RE+ +L R Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKI----SPFEHQTYCQRTLREIKILLR-- 96 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 F H N++ + D+ ++ V +V + ++ DL L L + I + Q Sbjct: 97 -FRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH---LSNDHICYFLYQI 152 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA----LTPVVVTLWY 180 LRGL ++H+ ++HRDLKP N+L+ + +K+ DFGLAR+ LT V T WY Sbjct: 153 LRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWY 212 Query: 181 RAPEV-LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 RAPE+ L Y +D+WSVGCI AEM +P+F G DQL I ++G P ++D Sbjct: 213 RAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 272 Query: 240 RDVSLPRGAF----PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 ++L + P + P + P + LL +MLTFNPHKRI +AL H YL Sbjct: 273 CIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 332 Query: 296 HKDEG 300 + Sbjct: 333 EQYYD 337 >1CM8-A nrPDB Length = 367 Score = 287 bits (736), Expect = 3e-78, Method: Composition-based stats. Identities = 107/307 (34%), Positives = 146/307 (47%), Gaps = 20/307 (6%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y + +G GAYG V A D +G VA+K + P + R LR L+ Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQS------ELFAKRAYRELRLLKH 80 Query: 66 FEHPNVVRLMDVCATSRT-DREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 H NV+ L+DV T D LV + DL + L + I+ L+ Q Sbjct: 81 MRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM---KHEKLGEDRIQFLVYQM 137 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 L+GL ++HA I+HRDLKP N+ V +K+ DFGLAR + +T VVT WYRAPE Sbjct: 138 LKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSE--MTGYVVTRWYRAPE 195 Query: 185 VLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 V+L Y VD+WSVGCI AEM K LF G+ DQL +I + G PP + R S Sbjct: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 Query: 244 LPRGAF----PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL---H 296 + P + S++ LL +ML + +R++A AL H Y H Sbjct: 256 DEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLH 315 Query: 297 KDEGNPE 303 E P+ Sbjct: 316 DTEDEPQ 322 >5EFQ-A nrPDB Length = 347 Score = 287 bits (736), Expect = 3e-78, Method: Composition-based stats. Identities = 112/309 (36%), Positives = 160/309 (51%), Gaps = 18/309 (5%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 +++ + IG G YG VYKARD +G VALK VR+ N G PI+ +RE+ +LR Sbjct: 9 CVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNE---KEGFPITAIREIKILR 65 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIK-----VTLVFEHVDQDLRTYLDKAPPPGLPAET 116 +L H +++ + ++ + K LVFE++D DL L+ Sbjct: 66 QL---THQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLES-GLVHFNENH 121 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA--LTPV 174 IK MRQ + GLD+ H +HRD+K NIL+ + G +KLADFGLAR+YS + + T Sbjct: 122 IKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNK 181 Query: 175 VVTLWYRAPEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 233 V+TLWYR PE+LL Y +D+WS GCI E+F +KP+F N E QL I + G P Sbjct: 182 VITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSP 241 Query: 234 PEDDWPRDVSLPRGAFPPRGP---RPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRAL 290 WP + LP R ++ + + L ML +P KR +A +AL Sbjct: 242 CPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQAL 301 Query: 291 QHSYLHKDE 299 Q +L E Sbjct: 302 QCEFLRDVE 310 >4NST-A nrPDB Length = 351 Score = 287 bits (734), Expect = 5e-78, Method: Composition-based stats. Identities = 112/309 (36%), Positives = 163/309 (52%), Gaps = 18/309 (5%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 +++ + IG G YG VYKA+D +G VALK VR+ N G PI+ +RE+ +LR Sbjct: 11 CVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNE---KEGFPITAIREIKILR 67 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIK-----VTLVFEHVDQDLRTYLDKAPPPGLPAET 116 +L H +VV + ++ + + K LVFE++D DL L+ + Sbjct: 68 QL---IHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLES-GLVHFSEDH 123 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA--LTPV 174 IK M+Q + GL++ H +HRD+K NIL+ + G +KLADFGLAR+Y+ + + T Sbjct: 124 IKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNK 183 Query: 175 VVTLWYRAPEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 233 V+TLWYR PE+LL Y +D+WS GCI E+F +KP+F N E QL I L G P Sbjct: 184 VITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSP 243 Query: 234 PEDDWPRDVSLPRGAFPPRGP---RPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRAL 290 WP + LP R ++ + + LL MLT +P KR +A + L Sbjct: 244 CPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTL 303 Query: 291 QHSYLHKDE 299 Q +L E Sbjct: 304 QSDFLKDVE 312 >4IC8-A nrPDB Length = 442 Score = 284 bits (727), Expect = 3e-77, Method: Composition-based stats. Identities = 107/314 (34%), Positives = 158/314 (50%), Gaps = 22/314 (7%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 YE + IG GAYG V AR +G VA+K + + + R + L+ L Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKI------PNAFDVVTNAKRTLRELKIL 108 Query: 64 EAFEHPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 + F+H N++ + D+ + E K V +V + ++ DL + + P L E ++ + Sbjct: 109 KHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQP--LTLEHVRYFLY 166 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-----SYQMALTPVVVT 177 Q LRGL ++H+ ++HRDLKP N+LV +K+ DFG+AR +Q +T V T Sbjct: 167 QLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVAT 226 Query: 178 LWYRAPEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPED 236 WYRAPE++L Y +D+WSVGCIF EM R+ LF G + QL I ++G P Sbjct: 227 RWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPA 286 Query: 237 DW----PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQH 292 V + PPR P P ++V P + LL ML F P RISA AL+H Sbjct: 287 VIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRH 346 Query: 293 SYL---HKDEGNPE 303 +L H + P+ Sbjct: 347 PFLAKYHDPDDEPD 360 >3OHT-A nrPDB Length = 389 Score = 284 bits (727), Expect = 4e-77, Method: Composition-based stats. Identities = 106/309 (34%), Positives = 147/309 (47%), Gaps = 20/309 (6%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 RY+ ++ +G GAYG+V + D SG +A+K + P I R LR L Sbjct: 51 ERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRPFQSI------IHAKRTYRELRLL 104 Query: 64 EAFEHPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 + +H NV+ L+DV + + E V LV + DL + L + ++ L+ Sbjct: 105 KHMKHENVIGLLDVFTPATSLEEFNDVYLVTHLMGADLNNIV---KCQKLTDDHVQFLIY 161 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 Q LRGL ++H+ I+HRDLKP N+ V +K+ DFGLAR +T V T WYRA Sbjct: 162 QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVATRWYRA 219 Query: 183 PEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 PE++L Y VD+WSVGCI AE+ + LF G +QL +I L G PP R Sbjct: 220 PEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRM 279 Query: 242 VSLPRGAF----PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL-- 295 S + P R V LL +ML + KRI+A AL H Y Sbjct: 280 PSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFSQ 339 Query: 296 -HKDEGNPE 303 H + PE Sbjct: 340 YHDPDDEPE 348 >4EWQ-A nrPDB Length = 383 Score = 283 bits (724), Expect = 7e-77, Method: Composition-based stats. Identities = 104/308 (33%), Positives = 148/308 (48%), Gaps = 20/308 (6%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 RY+ ++ +G GAYG+V A D +G VA+K + P I R LR L Sbjct: 45 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSI------IHAKRTYRELRLL 98 Query: 64 EAFEHPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 + +H NV+ L+DV +R+ E V LV + DL + L + ++ L+ Sbjct: 99 KHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV---KCQKLTDDHVQFLIY 155 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 Q LRGL ++H+ I+HRDLKP N+ V +K+ DFGLAR +T V T WYRA Sbjct: 156 QILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR--HTDDEMTGYVATRWYRA 213 Query: 183 PEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 PE++L Y VD+WSVGCI AE+ + LF G DQL I L+G P + + Sbjct: 214 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 273 Query: 242 VSLPRGAF----PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL-- 295 S + +V LL +ML + KRI+A +AL H+Y Sbjct: 274 SSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 333 Query: 296 -HKDEGNP 302 H + P Sbjct: 334 YHDPDDEP 341 >5AWM-A nrPDB Length = 394 Score = 282 bits (722), Expect = 1e-76, Method: Composition-based stats. Identities = 105/317 (33%), Positives = 143/317 (45%), Gaps = 27/317 (8%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 SRY + IG GA G V A D + VA+K + P RE L++ Sbjct: 44 SRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRPFQNVTHA---KRAYREFKLMK-- 98 Query: 64 EAFEHPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 H N++ L++ R E + V LV E +D +L + L + + L+ Sbjct: 99 -LVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ----MDLDHDRMSYLLY 153 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 Q L G+ LH+ I+HRDLKP NI+V + T+K+ DFGLAR +TP VVT +YRA Sbjct: 154 QMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTAGTTFMMTPYVVTRYYRA 213 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPE------- 235 PEV+L Y VD+WSVGCI EM R LF G DQ KI + +G P Sbjct: 214 PEVILGMGYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPSFMQRLQ 273 Query: 236 -------DDWPRDVSLPRGAFPPRG--PRPVQSVVPEMEESGAQLLLEMLTFNPHKRISA 286 ++ PR P G P LL +ML +P +RIS Sbjct: 274 PTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKMLVIDPEQRISV 333 Query: 287 FRALQHSYLHKDEGNPE 303 AL+H Y++ E Sbjct: 334 DEALKHEYINVWYDAEE 350 >1JNK-A nrPDB Length = 423 Score = 282 bits (722), Expect = 1e-76, Method: Composition-based stats. Identities = 109/309 (35%), Positives = 149/309 (48%), Gaps = 26/309 (8%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 RY+ + IG GA G V A D VA+K + P RE+ L++ Sbjct: 62 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA---KRAYRELVLMK-- 116 Query: 64 EAFEHPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 H N++ L++V +T E + V LV E +D +L + L E + L+ Sbjct: 117 -CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME----LDHERMSYLLY 171 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 Q L G+ LH+ I+HRDLKP NI+V S T+K+ DFGLAR +TP VVT +YRA Sbjct: 172 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRA 231 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW---- 238 PEV+L Y VD+WSVGCI EM R K LF G DQ K+ + +G P + Sbjct: 232 PEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ 291 Query: 239 ----------PRDVSLPRGAFPPRGPRPVQSVVPEMEES-GAQLLLEMLTFNPHKRISAF 287 P+ L P P S +++ S LL +ML +P KRIS Sbjct: 292 PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD 351 Query: 288 RALQHSYLH 296 ALQH Y++ Sbjct: 352 DALQHPYIN 360 >4QNY-A nrPDB Length = 354 Score = 282 bits (721), Expect = 1e-76, Method: Composition-based stats. Identities = 95/306 (31%), Positives = 143/306 (46%), Gaps = 14/306 (4%) Query: 3 TSRYEPVAEIGVGAYGTVYKARD-PHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 RY IG G+YG V +ARD VA+K RV L +RE+ LL Sbjct: 19 DDRYLLERIIGAGSYGVVIRARDTKSDNRLVAMK--RVNKEIFEEVILAKRILREIKLLA 76 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 F N++ L ++ + +V + ++ DL+ L L I+ + Sbjct: 77 H---FNDDNIIGLRNILTPEDPENFDHFYIVMDIMETDLKQVLRS--GQELTEAHIQFFI 131 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-LTPVVVTLWY 180 Q LR L +H+ ++HRD+ P NILV + +K+ DFGLA+ + Q +T V WY Sbjct: 132 YQALRALHIIHSAGVIHRDITPANILVNTNCDLKICDFGLAKEENDQGEYMTDYVTMRWY 191 Query: 181 RAPE-VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 RAPE V+ Y+ +D+W +GCI E+ +PLF G +QL KI D+IG P E+D Sbjct: 192 RAPELVMEDKDYSAQIDVWGIGCILGELLGSRPLFQGKDRVNQLDKIVDVIGTPSEEDIN 251 Query: 240 RDVSLPRGAFPP----RGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 S + R + P LL ML FNP +RI+ +A++H +L Sbjct: 252 SVGSSAAQKYLKKKSHRPQADWRQRYPTASPEALDLLRHMLVFNPKRRITVLQAMRHPFL 311 Query: 296 HKDEGN 301 + + Sbjct: 312 EQLHDD 317 >3FI2-A nrPDB Length = 353 Score = 280 bits (717), Expect = 5e-76, Method: Composition-based stats. Identities = 109/309 (35%), Positives = 149/309 (48%), Gaps = 26/309 (8%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 RY+ + IG GA G V A D VA+K + P RE+ L++ Sbjct: 24 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHA---KRAYRELVLMK-- 78 Query: 64 EAFEHPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 H N++ L++V +T E + V LV E +D +L + L E + L+ Sbjct: 79 -CVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQME----LDHERMSYLLY 133 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 Q L G+ LH+ I+HRDLKP NI+V S T+K+ DFGLAR +TP VVT +YRA Sbjct: 134 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRA 193 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW---- 238 PEV+L Y VD+WSVGCI EM R K LF G DQ K+ + +G P + Sbjct: 194 PEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQ 253 Query: 239 ----------PRDVSLPRGAFPPRGPRPVQSVVPEMEES-GAQLLLEMLTFNPHKRISAF 287 P+ L P P S +++ S LL +ML +P KRIS Sbjct: 254 PTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVD 313 Query: 288 RALQHSYLH 296 ALQH Y++ Sbjct: 314 DALQHPYIN 322 >4ZSG-A nrPDB Length = 347 Score = 280 bits (716), Expect = 5e-76, Method: Composition-based stats. Identities = 107/314 (34%), Positives = 158/314 (50%), Gaps = 22/314 (7%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 YE + IG GAYG V AR +G VA+K + + + R + L+ L Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKI------PNAFDVVTNAKRTLRELKIL 60 Query: 64 EAFEHPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 + F+H N++ + D+ + E K V +V + ++ DL + + P L E ++ + Sbjct: 61 KHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQP--LTLEHVRYFLY 118 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-----SYQMALTPVVVT 177 Q LRGL ++H+ ++HRDLKP N+LV +K+ DFG+AR +Q +T V T Sbjct: 119 QLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVAT 178 Query: 178 LWYRAPEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPED 236 WYRAPE++L Y +D+WSVGCIF EM R+ LF G + QL I ++G P Sbjct: 179 RWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPA 238 Query: 237 DW----PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQH 292 V + PPR P P ++V P + LL ML F P RISA AL+H Sbjct: 239 VIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRH 298 Query: 293 SYL---HKDEGNPE 303 +L H + P+ Sbjct: 299 PFLAKYHDPDDEPD 312 >3E7O-A nrPDB Length = 360 Score = 279 bits (713), Expect = 1e-75, Method: Composition-based stats. Identities = 106/309 (34%), Positives = 149/309 (48%), Gaps = 26/309 (8%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 RY+ + IG GA G V A D G VA+K + P RE+ L L Sbjct: 22 KRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHA---KRAYRELVL---L 75 Query: 64 EAFEHPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 + H N++ L++V +T E + V LV E +D +L + L E + L+ Sbjct: 76 KCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHME----LDHERMSYLLY 131 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 Q L G+ LH+ I+HRDLKP NI+V S T+K+ DFGLAR S +TP VVT +YRA Sbjct: 132 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTASTNFMMTPYVVTRYYRA 191 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW---- 238 PEV+L Y VD+WSVGCI E+ + +F G DQ K+ + +G P + Sbjct: 192 PEVILGMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAALQ 251 Query: 239 ----------PRDVSLPRGAFPPRGPRPVQSVVPEMEES-GAQLLLEMLTFNPHKRISAF 287 P + P P +S +++ S LL +ML +P KRIS Sbjct: 252 PTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVD 311 Query: 288 RALQHSYLH 296 AL+H Y+ Sbjct: 312 EALRHPYIT 320 >4MYG-A nrPDB Length = 372 Score = 278 bits (712), Expect = 2e-75, Method: Composition-based stats. Identities = 102/298 (34%), Positives = 143/298 (47%), Gaps = 18/298 (6%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G GAYG+V A D SG VA+K + P RE+ LL+ + +H NV Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQS---EIFAKRAYRELLLLKHM---QHENV 104 Query: 72 VRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 + L+DV + + R LV + DL K E I+ L+ Q L+GL + Sbjct: 105 IGLLDVFTPASSLRNFYDFYLVMPFMQTDL----QKIMGMEFSEEKIQYLVYQMLKGLKY 160 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQ-S 189 +H+ +VHRDLKP N+ V +K+ DFGLAR +T VVT WYRAPEV+L Sbjct: 161 IHSAGVVHRDLKPGNLAVNEDCELKILDFGLAR--HADAEMTGYVVTRWYRAPEVILSWM 218 Query: 190 TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAF 249 Y VD+WSVGCI AEM K LF G DQL +I + G+P + + ++ Sbjct: 219 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 278 Query: 250 ----PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 303 P + + P A LL +ML + KR++A +AL H + E Sbjct: 279 IQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEE 336 >2XS0-A nrPDB Length = 386 Score = 277 bits (709), Expect = 4e-75, Method: Composition-based stats. Identities = 102/309 (33%), Positives = 145/309 (46%), Gaps = 26/309 (8%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 RY+ + IG GA G V A D VA+K + P RE+ L++ Sbjct: 26 KRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHA---KRAYRELVLMK-- 80 Query: 64 EAFEHPNVVRLMDVCATSRTDREIK-VTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 H N++ L++V ++ E + V +V E +D +L + L E + L+ Sbjct: 81 -CVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME----LDHERMSYLLY 135 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 Q L G+ LH+ I+HRDLKP NI+V S T+K+ DFGLAR + P VVT +YRA Sbjct: 136 QMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMVPFVVTRYYRA 195 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW---- 238 PEV+L Y VD+WSVGCI EM + LF G DQ K+ + +G P + Sbjct: 196 PEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQ 255 Query: 239 ----------PRDVSLPRGAFPPRGPRPVQSVVPEMEES-GAQLLLEMLTFNPHKRISAF 287 P+ P P S +++ S LL +ML + KRIS Sbjct: 256 PTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVD 315 Query: 288 RALQHSYLH 296 ALQH Y++ Sbjct: 316 EALQHPYIN 324 >3GC9-A nrPDB Length = 370 Score = 276 bits (706), Expect = 9e-75, Method: Composition-based stats. Identities = 103/309 (33%), Positives = 151/309 (48%), Gaps = 20/309 (6%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 R + + +G GAYG+V A D VA+K + P I R LR L Sbjct: 28 QRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSL------IHARRTYRELRLL 81 Query: 64 EAFEHPNVVRLMDVCATSRT-DREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 + +H NV+ L+DV + + + +V LV + DL + L E ++ L+ Sbjct: 82 KHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKS---QALSDEHVQFLVY 138 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 Q LRGL ++H+ I+HRDLKP N+ V +++ DFGLAR +T V T WYRA Sbjct: 139 QLLRGLKYIHSAGIIHRDLKPSNVAVNEDSELRILDFGLARQ--ADEEMTGYVATRWYRA 196 Query: 183 PEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 PE++L Y VD+WSVGCI AE+ + K LF G+ DQL +I +++G P + + Sbjct: 197 PEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKI 256 Query: 242 VSLPRGAF----PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL-- 295 S + PP + + S+ LL ML + +R+SA AL H+Y Sbjct: 257 SSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQ 316 Query: 296 -HKDEGNPE 303 H E PE Sbjct: 317 YHDPEDEPE 325 >5G6V-A nrPDB Length = 324 Score = 275 bits (704), Expect = 1e-74, Method: Composition-based stats. Identities = 117/295 (39%), Positives = 171/295 (57%), Gaps = 18/295 (6%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y + ++G G Y TVYK + + + VALK +R+ + G P + +REV+LL+ L+ Sbjct: 4 YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGA----PCTAIREVSLLKDLK- 58 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 H N+V L D+ T ++ +TLVFE++D+DL+ YLD + +K + Q L Sbjct: 59 --HANIVTLHDIIHTEKS-----LTLVFEYLDKDLKQYLDDCGNI-INMHNVKLFLFQLL 110 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS-YQMALTPVVVTLWYRAPE 184 RGL + H ++HRDLKP+N+L+ G +KLADFGLAR S VVTLWYR P+ Sbjct: 111 RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPD 170 Query: 185 VLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 +LL ST Y+T +DMW VGCIF EM +PLF G++ +QL IF ++G P E+ WP +S Sbjct: 171 ILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILS 230 Query: 244 ---LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 +P + S P ++ GA LL ++L F RISA A++H + Sbjct: 231 NEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >3GC0-A nrPDB Length = 329 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 116/311 (37%), Positives = 183/311 (58%), Gaps = 23/311 (7%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 + RY + ++G G YG VYKA D + VA+K +R+ + G+P + +REV+LL+ Sbjct: 32 SIDRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLEHEE---EGVPGTAIREVSLLK 88 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 L +H N++ L V + ++ L+FE+ + DL+ Y+DK P + IK + Sbjct: 89 EL---QHRNIIELKSVIHHNH-----RLHLIFEYAENDLKKYMDKNPDVSM--RVIKSFL 138 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVT-----SGGTVKLADFGLARIYS-YQMALTPVV 175 Q + G++F H+ +HRDLKP+N+L++ +K+ DFGLAR + T + Sbjct: 139 YQLINGVNFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEI 198 Query: 176 VTLWYRAPEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 +TLWYR PE+LL Y+T VD+WS+ CI+AEM + PLF G+SE DQL KIF+++GLP Sbjct: 199 ITLWYRPPEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPD 258 Query: 235 EDDWPRDVSLP--RGAFPPRGPRPVQSVV-PEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 + WP +LP + +FP + ++ V+ +++ G LL ML +P KRISA AL+ Sbjct: 259 DTTWPGVTALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALE 318 Query: 292 HSYLHKDEGNP 302 H Y ++ +P Sbjct: 319 HPYFSHNDFDP 329 >3OZ6-A nrPDB Length = 388 Score = 275 bits (703), Expect = 2e-74, Method: Composition-based stats. Identities = 106/344 (30%), Positives = 160/344 (46%), Gaps = 57/344 (16%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 +YE V ++G GAYG V+K+ D +G VA+K + T RE+ +L L Sbjct: 10 KYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQ---RTFREIMILTELS 66 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 H N+V L++V R D + V LVF++++ DL + L + ++ Q Sbjct: 67 G--HENIVNLLNVL---RADNDRDVYLVFDYMETDLHAVIRAN---ILEPVHKQYVVYQL 118 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY------------------- 165 ++ + +LH+ ++HRD+KP NIL+ + VK+ADFGL+R + Sbjct: 119 IKVIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTE 178 Query: 166 ---SYQMALTPVVVTLWYRAPEVLLQS-TYATPVDMWSVGCIFAEMFRRKPLFCGNSEAD 221 Q LT V T WYRAPE+LL S Y +DMWS+GCI E+ KP+F G+S + Sbjct: 179 NFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMN 238 Query: 222 QLGKIFDLIGLPPEDDWPRDVSLPRGAFPP------------------RGPRPVQSVVPE 263 QL +I +I P +D S + + + P+ Sbjct: 239 QLERIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPK 298 Query: 264 M--EESGAQLLLEMLTFNPHKRISAFRALQHSY---LHKDEGNP 302 E LL ++L FNP+KRISA AL+H + H P Sbjct: 299 ADCNEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEP 342 >4BBM-A nrPDB Length = 331 Score = 274 bits (702), Expect = 2e-74, Method: Composition-based stats. Identities = 100/303 (33%), Positives = 153/303 (50%), Gaps = 18/303 (5%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 + +YE + +G G+YG V K R+ +G VA+K + +RE+ LL+ Sbjct: 23 SMEKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKF---LESDDDKMVKKIAMREIKLLK 79 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 +L H N+V L++VC + + LVFE VD + L+ P GL + ++ + Sbjct: 80 QLR---HENLVNLLEVCKKKK-----RWYLVFEFVDHTILDDLE-LFPNGLDYQVVQKYL 130 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-SYQMALTPVVVTLWY 180 Q + G+ F H++ I+HRD+KPENILV+ G VKL DFG AR + V T WY Sbjct: 131 FQIINGIGFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARTLAAPGEVYDDEVATRWY 190 Query: 181 RAPEVLLQS-TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG--LPPEDD 237 RAPE+L+ Y VD+W++GC+ EMF +PLF G+S+ DQL I +G +P + Sbjct: 191 RAPELLVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQE 250 Query: 238 WPRDVSLPRGAFPP--RGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 + G P + P++ P++ E L + L +P KR L H + Sbjct: 251 LFNKNPVFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFF 310 Query: 296 HKD 298 D Sbjct: 311 QMD 313 >3NCG-A nrPDB Length = 486 Score = 274 bits (701), Expect = 3e-74, Method: Composition-based stats. Identities = 82/303 (27%), Positives = 136/303 (44%), Gaps = 41/303 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 RY V +G G++G V K +D + A+K + + + +REV LL++ Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTS---TILREVELLKK 77 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFE-HVDQDLRTYLDKAPPPGLPAETIKDLM 121 L +HPN+++L ++ S + +V E + +L + K ++ Sbjct: 78 L---DHPNIMKLFEILEDSSS-----FYIVGELYTGGELFDEIIKRKR--FSEHDAARII 127 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTL 178 +Q G+ ++H + IVHRDLKPENIL+ S +K+ DFGL+ + + + T Sbjct: 128 KQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTA 187 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 +Y APEVL TY D+WS G I + P F G +E D L ++ Sbjct: 188 YYIAPEVLRG-TYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVE----------- 235 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + AF R + + L+ +MLTF+P RI+A + L+H ++ K Sbjct: 236 -----TGKYAFDLPQWR-------TISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKY 283 Query: 299 EGN 301 Sbjct: 284 SSE 286 >5JN2-A nrPDB Length = 525 Score = 274 bits (701), Expect = 3e-74, Method: Composition-based stats. Identities = 82/305 (26%), Positives = 131/305 (42%), Gaps = 40/305 (13%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + + RY+ +G G++G V +D +G A+K + S +REV LL Sbjct: 64 IFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVIS--KRQVKQKTDKESLLREVQLL 121 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFE-HVDQDLRTYLDKAPPPGLPAETIKD 119 ++L +HPN+++L + + LV E + +L + Sbjct: 122 KQL---DHPNIMKLYEFFED-----KGYFYLVGEVYTGGELFDEIISRKR--FSEVDAAR 171 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILV---TSGGTVKLADFGLARIYSYQMALTPVVV 176 ++RQ L G+ ++H N IVHRDLKPEN+L+ + +++ DFGL+ + + + Sbjct: 172 IIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIG 231 Query: 177 TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPED 236 T +Y APEVL TY D+WS G I + P F G +E D L K+ Sbjct: 232 TAYYIAPEVLHG-TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELP 290 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 W + + ES L+ +MLT+ P RISA AL H ++ Sbjct: 291 QWKK-----------------------VSESAKDLIRKMLTYVPSMRISARDALDHEWIQ 327 Query: 297 KDEGN 301 Sbjct: 328 TYTKE 332 >3HZT-A nrPDB Length = 467 Score = 274 bits (700), Expect = 4e-74, Method: Composition-based stats. Identities = 84/299 (28%), Positives = 134/299 (44%), Gaps = 40/299 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + RY+ V ++G GAYG V +D +G A+K ++ + + EVA+L++ Sbjct: 3 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIK--KSSVTTTSNSGALLDEVAVLKQ 60 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFE-HVDQDLRTYLDKAPPPGLPAETIKDLM 121 L +HPN+++L + R LV E + +L + +M Sbjct: 61 L---DHPNIMKLYEFFEDKRN-----YYLVMEVYRGGELFDEI--ILRQKFSEVDAAVIM 110 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTL 178 +Q L G +LH + IVHRDLKPEN+L+ S +K+ DFGL+ + + + T Sbjct: 111 KQVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTA 170 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 +Y APEVL + Y D+WS G I + P F G ++ + L ++ DW Sbjct: 171 YYIAPEVL-RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDW 229 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 ++ + QL+ MLT+ P KRISA AL H ++ K Sbjct: 230 -----------------------TQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWIVK 265 >3MIA-A nrPDB Length = 351 Score = 272 bits (697), Expect = 9e-74, Method: Composition-based stats. Identities = 110/309 (35%), Positives = 158/309 (51%), Gaps = 21/309 (6%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 S+YE +A+IG G +G V+KAR +G VALK V + N G PI+ +RE+ +L+ L Sbjct: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE---KEGFPITALREIKILQLL 73 Query: 64 EAFEHPNVVRLMDVCAT---SRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 + H NVV L+++C T + + LVF+ + DL L IK + Sbjct: 74 K---HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLL-SNVLVKFTLSEIKRV 129 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-----SYQMALTPVV 175 M+ L GL ++H N I+HRD+K N+L+T G +KLADFGLAR + S T V Sbjct: 130 MQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRV 189 Query: 176 VTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 VTLWYR PE+LL Y P+D+W GCI AEM+ R P+ GN+E QL I L G Sbjct: 190 VTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSIT 249 Query: 235 EDDWPRDVSLPRGAFPPRGPRPVQSVVPEM-----EESGAQLLLEMLTFNPHKRISAFRA 289 + WP + + V + + L+ ++L +P +RI + A Sbjct: 250 PEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDA 309 Query: 290 LQHSYLHKD 298 L H + D Sbjct: 310 LNHDFFWSD 318 >4MVF-A nrPDB Length = 506 Score = 272 bits (695), Expect = 1e-73, Method: Composition-based stats. Identities = 72/304 (23%), Positives = 126/304 (41%), Gaps = 43/304 (14%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 +Y ++G G YG VYK D + A+K + +E+ ++++L Sbjct: 57 DKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDRLKNIN-----RFFQEIEIMKKL 111 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMR 122 +HPN+V+L + + + L+ E +L + + + +M+ Sbjct: 112 ---DHPNIVKLYETYE-----NDNYIYLIMELCSGRELFDSIIENG--SFTEKNAATIMK 161 Query: 123 QFLRGLDFLHANCIVHRDLKPENILV---TSGGTVKLADFGLARIYSYQMALTPVVVTLW 179 Q + +LH+ IVHRDLKPEN L +K+ DFGL++ T T + Sbjct: 162 QIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPY 221 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 Y AP+VL Y D+WS G I + P F G+++ + L K+ E+DW Sbjct: 222 YVAPQVL-DGKYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWG 280 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE 299 + L+ ++LT+NP++R + AL H ++ + Sbjct: 281 S-----------------------ISSDAKNLITKLLTYNPNERCTIEEALNHPWITQMT 317 Query: 300 GNPE 303 + E Sbjct: 318 KSHE 321 >3DFA-A nrPDB Length = 286 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 82/303 (27%), Positives = 136/303 (44%), Gaps = 41/303 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 RY V +G G++G V K +D + A+K + + + +REV LL++ Sbjct: 21 AERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKNKDTS---TILREVELLKK 77 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFE-HVDQDLRTYLDKAPPPGLPAETIKDLM 121 L +HPN+++L ++ S + +V E + +L + K ++ Sbjct: 78 L---DHPNIMKLFEILEDSSS-----FYIVGELYTGGELFDEIIKRKR--FSEHDAARII 127 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTL 178 +Q G+ ++H + IVHRDLKPENIL+ S +K+ DFGL+ + + + T Sbjct: 128 KQVFSGITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTA 187 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 +Y APEVL TY D+WS G I + P F G +E D L ++ Sbjct: 188 YYIAPEVLRG-TYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVE----------- 235 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + AF R + + L+ +MLTF+P RI+A + L+H ++ K Sbjct: 236 -----TGKYAFDLPQWR-------TISDDAKDLIRKMLTFHPSLRITATQCLEHPWIQKY 283 Query: 299 EGN 301 Sbjct: 284 SSE 286 >3DXN-A nrPDB Length = 287 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 84/299 (28%), Positives = 134/299 (44%), Gaps = 40/299 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + RY+ V ++G GAYG V +D +G A+K ++ + + EVA+L++ Sbjct: 20 SDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIK--KSSVTTTSNSGALLDEVAVLKQ 77 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFE-HVDQDLRTYLDKAPPPGLPAETIKDLM 121 L +HPN+++L + R LV E + +L + +M Sbjct: 78 L---DHPNIMKLYEFFEDKRN-----YYLVMEVYRGGELFDEI--ILRQKFSEVDAAVIM 127 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTL 178 +Q L G +LH + IVHRDLKPEN+L+ S +K+ DFGL+ + + + T Sbjct: 128 KQVLSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTA 187 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 +Y APEVL + Y D+WS G I + P F G ++ + L ++ DW Sbjct: 188 YYIAPEVL-RKKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDW 246 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 ++ + QL+ MLT+ P KRISA AL H ++ K Sbjct: 247 -----------------------TQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWIVK 282 >4AGU-A nrPDB Length = 311 Score = 271 bits (694), Expect = 2e-73, Method: Composition-based stats. Identities = 97/300 (32%), Positives = 154/300 (51%), Gaps = 18/300 (6%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 +YE + +IG G+YG V+K R+ +G VA+K + +RE+ +L++ Sbjct: 2 MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKF---LESEDDPVIKKIALREIRMLKQ 58 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L+ HPN+V L++V R+ ++ LVFE+ D + LD+ G+P +K + Sbjct: 59 LK---HPNLVNLLEVF-----RRKRRLHLVFEYCDHTVLHELDRYQR-GVPEHLVKSITW 109 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS-YQMALTPVVVTLWYR 181 Q L+ ++F H + +HRD+KPENIL+T +KL DFG AR+ + V T WYR Sbjct: 110 QTLQAVNFCHKHNCIHRDVKPENILITKHSVIKLCDFGFARLLTGPSDYYDDEVATRWYR 169 Query: 182 APEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG--LPPEDDW 238 +PE+L+ T Y PVD+W++GC+FAE+ PL+ G S+ DQL I +G +P Sbjct: 170 SPELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQV 229 Query: 239 PRDVSLPRGAFPPRG--PRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 G P P++ P + LL L +P +R++ + L H Y Sbjct: 230 FSTNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFE 289 >3LIJ-A nrPDB Length = 494 Score = 269 bits (689), Expect = 8e-73, Method: Composition-based stats. Identities = 83/305 (27%), Positives = 136/305 (44%), Gaps = 41/305 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + Y+ V ++G GAYG V RD + A+K +R + + EVA+L+ Sbjct: 36 SEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSNS---KLLEEVAVLKL 92 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFE-HVDQDLRTYLDKAPPPGLPAETIKDLM 121 L +HPN+++L D R LV E + +L + ++ Sbjct: 93 L---DHPNIMKLYDFFEDKRN-----YYLVMECYKGGELFDEI--IHRMKFNEVDAAVII 142 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTL 178 +Q L G+ +LH + IVHRDLKPEN+L+ S +K+ DFGL+ ++ Q + + T Sbjct: 143 KQVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTA 202 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 +Y APEVL + Y D+WS+G I + P F G ++ + L K+ +W Sbjct: 203 YYIAPEVL-RKKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPEW 261 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + E L+ +ML F+ +RISA +AL+H ++ + Sbjct: 262 K-----------------------NVSEGAKDLIKQMLQFDSQRRISAQQALEHPWIKEM 298 Query: 299 EGNPE 303 E Sbjct: 299 CSKKE 303 >3PG1-A nrPDB Length = 362 Score = 269 bits (689), Expect = 9e-73, Method: Composition-based stats. Identities = 100/300 (33%), Positives = 140/300 (46%), Gaps = 11/300 (3%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTV---REVALLRR 62 Y I G+YG V D G VA+K V G + + R + +R Sbjct: 24 YTVQRFISSGSYGAVCAGVDSE-GIPVAIKRVFNTVSDGRTVNILSDSFLCKRVLREIRL 82 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L F HPN++ L D+ K+ LV E + DL + + + I+ M Sbjct: 83 LNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQVIHDQR-IVISPQHIQYFMY 141 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 L GL LH +VHRDL P NIL+ + + DF LAR + T V WYRA Sbjct: 142 HILLGLHVLHEAGVVHRDLHPGNILLADNNDITICDFNLAREDTADANKTHYVTHRWYRA 201 Query: 183 PEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW--- 238 PE+++Q + VDMWS GC+ AEMF RK LF G++ +QL KI +++G P +D Sbjct: 202 PELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEVVGTPKIEDVVMF 261 Query: 239 --PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 P R + R +VVP + L+ +ML FNP +RIS +AL+H Y Sbjct: 262 SSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRISTEQALRHPYFE 321 >3MA6-A nrPDB Length = 298 Score = 267 bits (684), Expect = 3e-72, Method: Composition-based stats. Identities = 82/305 (26%), Positives = 131/305 (42%), Gaps = 40/305 (13%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + + RY+ +G G++G V +D +G A+K + S +REV LL Sbjct: 29 IFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVIS--KRQVKQKTDKESLLREVQLL 86 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFE-HVDQDLRTYLDKAPPPGLPAETIKD 119 ++L +HPN+++L + + LV E + +L + Sbjct: 87 KQL---DHPNIMKLYEFFED-----KGYFYLVGEVYTGGELFDEIISRKR--FSEVDAAR 136 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILV---TSGGTVKLADFGLARIYSYQMALTPVVV 176 ++RQ L G+ ++H N IVHRDLKPEN+L+ + +++ DFGL+ + + + Sbjct: 137 IIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKIG 196 Query: 177 TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPED 236 T +Y APEVL TY D+WS G I + P F G +E D L K+ Sbjct: 197 TAYYIAPEVLHG-TYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELP 255 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 W + + ES L+ +MLT+ P RISA AL H ++ Sbjct: 256 QWKK-----------------------VSESAKDLIRKMLTYVPSMRISARDALDHEWIQ 292 Query: 297 KDEGN 301 Sbjct: 293 TYTKE 297 >4BGQ-A nrPDB Length = 304 Score = 266 bits (681), Expect = 7e-72, Method: Composition-based stats. Identities = 96/302 (31%), Positives = 146/302 (48%), Gaps = 19/302 (6%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 +++E + +G GAYG V K R + VA+K + + +T+RE+ +LR Sbjct: 10 VMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFK---DSEENEEVKETTLRELKMLR 66 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 L+ N+V L + R K+ LVFE+V++++ L++ P G+P E +K + Sbjct: 67 TLKQ---ENIVELKEAF-----RRRGKLYLVFEYVEKNMLELLEEM-PNGVPPEKVKSYI 117 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA--LTPVVVTLW 179 Q ++ + + H N IVHRD+KPEN+L++ +KL DFG AR S V T W Sbjct: 118 YQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYDEEVATRW 177 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 YR+PE+LL + Y VDMWSVGCI E+ +PLF G SE DQL I ++G P + Sbjct: 178 YRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMK 237 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPE-----MEESGAQLLLEMLTFNPHKRISAFRALQHSY 294 S PR + + L+ +L +P R + L H Sbjct: 238 LFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPT 297 Query: 295 LH 296 Sbjct: 298 FQ 299 >3N9X-A nrPDB Length = 432 Score = 265 bits (677), Expect = 2e-71, Method: Composition-based stats. Identities = 116/350 (33%), Positives = 158/350 (45%), Gaps = 64/350 (18%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 Y IG G+YG VY A D ++ VA+K V N +RE+ +L RL Sbjct: 26 DNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKV---NRMFEDLIDCKRILREITILNRL 82 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 ++ ++RL D+ + ++ +V E D DL+ P L E IK ++ Sbjct: 83 KS---DYIIRLYDLIIPDDLLKFDELYIVLEIADSDLKKLFK--TPIFLTEEHIKTILYN 137 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ--------------- 168 L G +F+H + I+HRDLKP N L+ +VK+ DFGLAR + + Sbjct: 138 LLLGENFIHESGIIHRDLKPANCLLNQDCSVKVCDFGLARTINSEKDTNIVNDLEENEEP 197 Query: 169 --------MALTPVVVTLWYRAPE-VLLQSTYATPVDMWSVGCIFAEMF----------- 208 LT VVT WYRAPE +LLQ Y +D+WS GCIFAE+ Sbjct: 198 GPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLNMLQSHINDPT 257 Query: 209 RRKPLFCGN-----------------SEADQLGKIFDLIGLPPEDDWPRDVSLPR----G 247 R PLF G+ S DQL IF++IG P EDD Sbjct: 258 NRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNINKPEVIKYIK 317 Query: 248 AFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 FP R P ++ P + + G LL ML FNP+KRI+ +AL H YL Sbjct: 318 LFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKD 367 >4YZB-A nrPDB Length = 491 Score = 264 bits (674), Expect = 5e-71, Method: Composition-based stats. Identities = 75/302 (24%), Positives = 123/302 (40%), Gaps = 40/302 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + RY+ +G G++G V +D +G A+K + + Sbjct: 29 SDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEV-----EL 83 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFE-HVDQDLRTYLDKAPPPGLPAETIKDLM 121 L+ +HPN+++L + + LV E + +L + ++ Sbjct: 84 LKKLDHPNIMKLYEFFED-----KGYFYLVTEVYTGGELFDEIISRKR--FSEVDAARII 136 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTL 178 RQ L G+ ++H N IVHRDLKPEN+L+ + +++ DFGL+ + + + T Sbjct: 137 RQVLSGITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTA 196 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 +Y APEVL TY D+WS G I + P F G +E D L K+ W Sbjct: 197 YYIAPEVLHG-TYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQW 255 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + + E L+ +ML + P RISA AL+H +L Sbjct: 256 KK-----------------------VSEPAKDLIRKMLAYVPTMRISARDALEHEWLKTT 292 Query: 299 EG 300 + Sbjct: 293 DA 294 >2BDW-A nrPDB Length = 362 Score = 263 bits (672), Expect = 7e-71, Method: Composition-based stats. Identities = 83/301 (27%), Positives = 122/301 (40%), Gaps = 40/301 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + Y+ E+G GA+ V + +G A K + RE + R+ Sbjct: 28 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQ---KLEREARICRK 84 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLM 121 L +HPN+VRL D E LVF+ V +L + + Sbjct: 85 L---QHPNIVRLHDSI-----QEESFHYLVFDLVTGGELFEDI--VAREFYSEADASHCI 134 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTL 178 +Q L + + H+N IVHR+LKPEN+L+ S G VKLADFGLA + A T Sbjct: 135 QQILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTP 194 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y +PEVL + Y+ PVD+W+ G I + P F + +I P +W Sbjct: 195 GYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEW 254 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + L+ MLT NP KRI+A +AL+ ++ Sbjct: 255 -----------------------DTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNR 291 Query: 299 E 299 E Sbjct: 292 E 292 >2VN9-A nrPDB Length = 301 Score = 262 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 85/302 (28%), Positives = 119/302 (39%), Gaps = 39/302 (12%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 T Y+ E+G GA+ V + +G A K + RE + R Sbjct: 3 TDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARD---HQKLEREARICRL 59 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L+ HPN+VRL D + LVF+ V + D ++ Sbjct: 60 LK---HPNIVRLHDSISEEGFH-----YLVFDLVTGG-ELFEDIVAREYYSEADASHCIQ 110 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGT---VKLADFGLA-RIYSYQMALTPVVVTL 178 Q L ++ H N IVHRDLKPEN+L+ S VKLADFGLA + Q A T Sbjct: 111 QILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTP 170 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y +PEVL + Y PVDMW+ G I + P F + +I P +W Sbjct: 171 GYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEW 230 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + L+ +MLT NP KRI+A AL+H ++ + Sbjct: 231 -----------------------DTVTPEAKDLINKMLTINPAKRITASEALKHPWICQR 267 Query: 299 EG 300 Sbjct: 268 ST 269 >3RP9-A nrPDB Length = 458 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 111/358 (31%), Positives = 153/358 (42%), Gaps = 72/358 (20%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 RYE IG G+YG V +A D VA+K + +RE+A+L RL Sbjct: 53 DRYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKI---LRVFEDLIDCKRILREIAILNRL 109 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 H +VV+++D+ ++ ++ +V E D D + P L IK L+ Sbjct: 110 ---NHDHVVKVLDIVIPKDVEKFDELYVVLEIADSDFKKLFR--TPVYLTELHIKTLLYN 164 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY---------------- 167 L G+ ++H+ I+HRDLKP N LV +VK+ DFGLAR Y Sbjct: 165 LLVGVKYVHSAGILHRDLKPANCLVNQDCSVKVCDFGLARTVDYPENGNSQLPISPREDD 224 Query: 168 ------------QMALTPVVVTLWYRAPE-VLLQSTYATPVDMWSVGCIFAEMFR----- 209 + LT VVT WYRAPE +LLQ Y +D+WS+GCIFAE+ Sbjct: 225 MNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNMIKEN 284 Query: 210 ------RKPLFCGNS--------------------EADQLGKIFDLIGLPPEDDW----P 239 R PLF G+S DQL IF+++G P E+D Sbjct: 285 VAYHADRGPLFPGSSCFPLSPDQKAGNDFKFHTRGNRDQLNVIFNILGTPSEEDIEALEK 344 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 D FP R + P LL ML FNP+KRI+ L H + + Sbjct: 345 EDAKRYIRIFPKREGTDLAERFPASSADAIHLLKRMLVFNPNKRITINECLAHPFFKE 402 >5FG8-A nrPDB Length = 285 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 83/302 (27%), Positives = 121/302 (40%), Gaps = 41/302 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + Y+ E+G GA+ V + +G A K + RE + R+ Sbjct: 13 SDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQ---KLEREARICRK 69 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLM 121 L HPN+VRL D E LVF+ V +L + + Sbjct: 70 L---HHPNIVRLHDSI-----QEENYHYLVFDLVTGGELFEDI--VAREFYSEADASHCI 119 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLA-RIYSYQMALTPVVVT 177 +Q L ++ H N +VHRDLKPEN+L+ S G VKLADFGLA + A T Sbjct: 120 QQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGT 179 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 Y +PEVL + Y VD+W+ G I + P F + +I P + Sbjct: 180 PGYLSPEVLKKEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPE 239 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 W + L+ +MLT NP+KRI+A AL+H ++ + Sbjct: 240 W-----------------------DTVTPEAKNLINQMLTVNPNKRITAAEALKHPWICQ 276 Query: 298 DE 299 E Sbjct: 277 RE 278 >3KK8-A nrPDB Length = 284 Score = 260 bits (665), Expect = 5e-70, Method: Composition-based stats. Identities = 83/301 (27%), Positives = 122/301 (40%), Gaps = 40/301 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + Y+ E+G GA+ V + +G A K + RE + R+ Sbjct: 5 SDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQ---KLEREARICRK 61 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLM 121 L +HPN+VRL D E LVF+ V +L + + Sbjct: 62 L---QHPNIVRLHDSI-----QEESFHYLVFDLVTGGELFEDI--VAREFYSEADASHCI 111 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTL 178 +Q L + + H+N IVHR+LKPEN+L+ S G VKLADFGLA + A T Sbjct: 112 QQILESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTP 171 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y +PEVL + Y+ PVD+W+ G I + P F + +I P +W Sbjct: 172 GYLSPEVLKKDPYSKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEW 231 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + L+ MLT NP KRI+A +AL+ ++ Sbjct: 232 -----------------------DTVTPEAKSLIDSMLTVNPKKRITADQALKVPWICNR 268 Query: 299 E 299 E Sbjct: 269 E 269 >5AIR-A nrPDB Length = 430 Score = 260 bits (664), Expect = 7e-70, Method: Composition-based stats. Identities = 87/297 (29%), Positives = 140/297 (47%), Gaps = 19/297 (6%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y IG G++G VY+A+ SG VA+K V RE+ ++R+L Sbjct: 66 YTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKN---------RELQIMRKL-- 114 Query: 66 FEHPNVVRLMDVCATSRTDR-EIKVTLVFEHVDQDLRTYLD--KAPPPGLPAETIKDLMR 122 +H N+VRL +S + E+ + LV ++V + + LP +K M Sbjct: 115 -DHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMY 173 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTV-KLADFGLARIYSYQMALTPVVVTLWYR 181 Q R L ++H+ I HRD+KP+N+L+ V KL DFG A+ + + +YR Sbjct: 174 QLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYR 233 Query: 182 APEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 APE++ +T Y + +D+WS GC+ AE+ +P+F G+S DQL +I ++G P + Sbjct: 234 APELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIRE 293 Query: 241 -DVSLPRGAFPPRGPRPVQSVV-PEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 + + FP P V P L +L + P R++ A HS+ Sbjct: 294 MNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFF 350 >4O2Z-A nrPDB Length = 377 Score = 259 bits (662), Expect = 1e-69, Method: Composition-based stats. Identities = 104/308 (33%), Positives = 153/308 (49%), Gaps = 17/308 (5%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 S+Y + +G+GAYG D +G V++K R G +RE+ ++R Sbjct: 45 SKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRDVFRDVEDG---KRVLREIDMMR-- 99 Query: 64 EAFEHPNVVRLMDVC--ATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 F H N++ ++++ V +V +D D+ L L ++ + Sbjct: 100 -FFHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSR--QVLEESHMQYFV 156 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS-YQMALTPVVVTLWY 180 Q LRGL +LH+ + HRDLKP N++ +K+ DFGL+R LT V+T WY Sbjct: 157 YQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVDVPYSELTDYVITRWY 216 Query: 181 RAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 R PE+LL++T Y+T VD+WSVGCIFAEM+ RKP+F G + DQL I IG PP Sbjct: 217 RPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVE 276 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEM--EESGAQLLLEMLTFNPHKRISAFRALQHSY--- 294 +L + P G + +VP + G L +M T +P KR +A L H Y Sbjct: 277 HREALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAH 336 Query: 295 LHKDEGNP 302 LH +E P Sbjct: 337 LHDEEDEP 344 >2V7O-A nrPDB Length = 336 Score = 258 bits (660), Expect = 2e-69, Method: Composition-based stats. Identities = 82/303 (27%), Positives = 119/303 (39%), Gaps = 41/303 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 T Y+ E+G GA+ V + A K + RE + R Sbjct: 30 TDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARD---HQKLEREARICRL 86 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLM 121 L+ HPN+VRL D + LVF+ V +L + + Sbjct: 87 LK---HPNIVRLHDSISEEGFH-----YLVFDLVTGGELFEDI--VAREYYSEADASHCI 136 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGT---VKLADFGLA-RIYSYQMALTPVVVT 177 Q L ++ +H + IVHRDLKPEN+L+ S VKLADFGLA + Q A T Sbjct: 137 HQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGT 196 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 Y +PEVL + Y PVD+W+ G I + P F + +I P + Sbjct: 197 PGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPE 256 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 W + L+ +MLT NP KRI+A +AL+H ++ + Sbjct: 257 W-----------------------DTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQ 293 Query: 298 DEG 300 Sbjct: 294 RST 296 >3COM-A nrPDB Length = 314 Score = 258 bits (660), Expect = 2e-69, Method: Composition-based stats. Identities = 71/296 (23%), Positives = 132/296 (44%), Gaps = 40/296 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 ++ + ++G G+YG+VYKA +G VA+K V V + ++E++++++ ++ Sbjct: 31 FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQ-------EIIKEISIMQQCDS 83 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 P+VV+ + + +V E+ + + + L + I +++ L Sbjct: 84 ---PHVVKYYGSY-----FKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTL 135 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVV-VTLWYRAPE 184 +GL++LH +HRD+K NIL+ + G KLADFG+A + MA V T ++ APE Sbjct: 136 KGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 195 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244 V+ + Y D+WS+G EM KP + + I Sbjct: 196 VIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMI------------------ 237 Query: 245 PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 300 P P P ++ + + L +P +R +A + LQH ++ +G Sbjct: 238 ------PTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKG 287 >3NIE-A nrPDB Length = 429 Score = 258 bits (659), Expect = 2e-69, Method: Composition-based stats. Identities = 113/357 (31%), Positives = 156/357 (43%), Gaps = 67/357 (18%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 YE IG G+YG VY A D ++ VA+K V N +RE+ +L RL Sbjct: 28 DNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKV---NRMFEDLIDCKRILREITILNRL 84 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 ++ ++RL D+ + ++ +V E D DL+ P L + +K ++ Sbjct: 85 KS---DYIIRLHDLIIPEDLLKFDELYIVLEIADSDLKKLFK--TPIFLTEQHVKTILYN 139 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ--------------- 168 L G F+H + I+HRDLKP N L+ +VK+ DFGLAR + Sbjct: 140 LLLGEKFIHESGIIHRDLKPANCLLNQDCSVKICDFGLARTINSDKDIHIVNDLEEKEEN 199 Query: 169 -----------MALTPVVVTLWYRAPE-VLLQSTYATPVDMWSVGCIFAEMF-------- 208 LT VVT WYRAPE +LLQ Y +D+WS GCIFAE+ Sbjct: 200 EEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLNMMKSHIN 259 Query: 209 ---RRKPLFCGN-----------------SEADQLGKIFDLIGLPPEDDW----PRDVSL 244 R PLF G+ S DQL IF++IG PPE+D ++V Sbjct: 260 NPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCITKQEVIK 319 Query: 245 PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGN 301 FP R + + + G LL ML FN KRI+ +AL H YL Sbjct: 320 YIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKDVRKE 376 >5U6Y-A nrPDB Length = 461 Score = 257 bits (657), Expect = 4e-69, Method: Composition-based stats. Identities = 82/299 (27%), Positives = 117/299 (39%), Gaps = 39/299 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y+ E+G GA+ V + +G A K + RE + R L+ Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARD---HQKLEREARICRLLK- 57 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 HPN+VRL D + E L+F+ V + D ++Q L Sbjct: 58 --HPNIVRLHDSIS-----EEGHHYLIFDLVTGG-ELFEDIVAREYYSEADASHCIQQIL 109 Query: 126 RGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLA-RIYSYQMALTPVVVTLWYR 181 + H +VHRDLKPEN+L+ S G VKLADFGLA + Q A T Y Sbjct: 110 EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYL 169 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 +PEVL + Y PVD+W+ G I + P F + +I P +W Sbjct: 170 SPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEW--- 226 Query: 242 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 300 + L+ +MLT NP KRI+A AL+H ++ Sbjct: 227 --------------------DTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRST 265 >3MN3-A nrPDB Length = 271 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 77/297 (25%), Positives = 122/297 (41%), Gaps = 40/297 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 Y+ V +G G++G V A +G VALK + + RE++ LR Sbjct: 3 IGNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKK--VLAKSDMQGRIEREISYLRL 60 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L HP++++L DV + + ++ +V E+ +L Y+ + + + + Sbjct: 61 LR---HPHIIKLYDVIKS-----KDEIIMVIEYAGNELFDYI--VQRDKMSEQEARRFFQ 110 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 Q + +++ H + IVHRDLKPEN+L+ VK+ADFGL+ I + L + Y A Sbjct: 111 QIISAVEYCHRHKIVHRDLKPENLLLDEHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAA 170 Query: 183 PEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 PEV+ Y VD+WS G I M R+ F S I + + P Sbjct: 171 PEVISGKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLP------- 223 Query: 242 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + A L+ ML NP RIS +Q + D Sbjct: 224 --------------------KFLSPGAAGLIKRMLIVNPLNRISIHEIMQDDWFKVD 260 >4E7W-A nrPDB Length = 394 Score = 255 bits (653), Expect = 1e-68, Method: Composition-based stats. Identities = 91/297 (30%), Positives = 145/297 (48%), Gaps = 20/297 (6%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y IG G++G V++A+ S VA+K V RE+ ++R ++ Sbjct: 42 YTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFKN---------RELQIMRIVK- 90 Query: 66 FEHPNVVRLMDVCATSRTDR-EIKVTLVFEHVDQDLR--TYLDKAPPPGLPAETIKDLMR 122 HPNVV L ++ + E+ + LV E+V + + + +P IK M Sbjct: 91 --HPNVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTMPMLLIKLYMY 148 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTS-GGTVKLADFGLARIYSYQMALTPVVVTLWYR 181 Q LR L ++H+ I HRD+KP+N+L+ G +KL DFG A+I + + +YR Sbjct: 149 QLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPNVSYICSRYYR 208 Query: 182 APEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 APE++ +T Y T +D+WS GC+ AE+ + +PLF G S DQL +I ++G P + Sbjct: 209 APELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVLGTPSREQIKT 268 Query: 241 -DVSLPRGAFPPRGPRPVQSVV-PEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 + + FP P P V P L+ +L + P R++A AL H + Sbjct: 269 MNPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIEALCHPFF 325 >4RGJ-A nrPDB Length = 520 Score = 255 bits (653), Expect = 1e-68, Method: Composition-based stats. Identities = 79/301 (26%), Positives = 135/301 (44%), Gaps = 41/301 (13%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + +Y+ + +G G++G V +RD H+GH A+K + + S +REV LL Sbjct: 57 VFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKHV--KRKTDKESLLREVELL 114 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFE-HVDQDLRTYLDKAPPPGLPAETIKD 119 + L +H N+++L + + LV + + +L + Sbjct: 115 KML---DHINIMKLYEFFEDNN-----YYYLVSDVYTGGELFDEIISRKR--FYEIDAAR 164 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILV----TSGGTVKLADFGLARIYSYQMALTPVV 175 +++Q L G+ ++H N +VHRDLKPENIL+ +K+ DFGL+ + Y + + Sbjct: 165 IIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLSTHFEYSKKMKDKI 224 Query: 176 VTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPE 235 T +Y AP+VL TY D+WS G I + P F G++E D L K+ Sbjct: 225 GTAYYIAPDVLHG-TYDEKCDIWSCGVILYILLSGCPPFNGSNEYDILKKV--------- 274 Query: 236 DDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 G + P+ ++ + L+ +ML + RISA AL+H ++ Sbjct: 275 ---------EAGKYTFDLPQ-----FKKISDKAKDLIKKMLMYTSAVRISARDALEHEWI 320 Query: 296 H 296 Sbjct: 321 K 321 >3BHH-A nrPDB Length = 295 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 82/302 (27%), Positives = 117/302 (38%), Gaps = 39/302 (12%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 T Y+ +IG GA+ V + +GH A K + RE + R Sbjct: 3 TDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARD---HQKLEREARICRL 59 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L+ H N+VRL D + LVF+ V + D ++ Sbjct: 60 LK---HSNIVRLHDSISEEGFH-----YLVFDLVTGG-ELFEDIVAREYYSEADASHCIQ 110 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGT---VKLADFGLA-RIYSYQMALTPVVVTL 178 Q L + H +VHRDLKPEN+L+ S VKLADFGLA + Q A T Sbjct: 111 QILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTP 170 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y +PEVL + Y PVD+W+ G I + P F + +I P +W Sbjct: 171 GYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEW 230 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + L+ +MLT NP KRI+A AL+H ++ + Sbjct: 231 -----------------------DTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQR 267 Query: 299 EG 300 Sbjct: 268 ST 269 >2VZ6-A nrPDB Length = 313 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 82/299 (27%), Positives = 117/299 (39%), Gaps = 39/299 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y+ E+G GA+ V + +G A K + RE + R L+ Sbjct: 24 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARD---HQKLEREARICRLLK- 79 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 HPN+VRL D + E L+F+ V + D ++Q L Sbjct: 80 --HPNIVRLHDSIS-----EEGHHYLIFDLVTGG-ELFEDIVAREYYSEADASHCIQQIL 131 Query: 126 RGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLA-RIYSYQMALTPVVVTLWYR 181 + H +VHRDLKPEN+L+ S G VKLADFGLA + Q A T Y Sbjct: 132 EAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYL 191 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 +PEVL + Y PVD+W+ G I + P F + +I P +W Sbjct: 192 SPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEW--- 248 Query: 242 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 300 + L+ +MLT NP KRI+A AL+H ++ Sbjct: 249 --------------------DTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRST 287 >5Y86-A nrPDB Length = 588 Score = 254 bits (650), Expect = 3e-68, Method: Composition-based stats. Identities = 92/335 (27%), Positives = 147/335 (43%), Gaps = 50/335 (14%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 RYE + IG G++G V + D +VALK VR E+ +L L+ Sbjct: 208 RYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKR------FHRQAAEEIRILEHLK 261 Query: 65 AFE---HPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 + NV+ +++ V + FE + DL + K G + ++ Sbjct: 262 KQDKTGSMNVIHMLESFTF-----RNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFA 316 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGT--VKLADFGLARIYSYQMALTPVVVTLW 179 + L+ LD LH N I+H DLKPENIL+ G K+ DFG + L + + + Sbjct: 317 QSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF--EYQKLYTYIQSRF 374 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 YRAPE++L S Y+TP+D+WS GCI AE+ +PLF G E DQL + +L+G+PP Sbjct: 375 YRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLE 434 Query: 240 RDVS---------LPRGAFP----------------------PRGPRPVQSVVPEMEE-S 267 + +PR P G + + + ++ Sbjct: 435 QSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYL 494 Query: 268 GAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNP 302 + L L ++P R++ +AL+H ++ K P Sbjct: 495 FIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRP 529 >3ZDU-A nrPDB Length = 325 Score = 254 bits (650), Expect = 3e-68, Method: Composition-based stats. Identities = 98/303 (32%), Positives = 153/303 (50%), Gaps = 19/303 (6%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 + YE + ++G G+YGTV K + ++G VA+K + +RE+ L+ Sbjct: 1 SMEMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKI----FYERPEQSVNKIAMREIKFLK 56 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 + F H N+V L++V + K+ LVFE +D + L + GL ++ ++ + Sbjct: 57 Q---FHHENLVNLIEVFRQKK-----KIHLVFEFIDHTVLDEL-QHYCHGLESKRLRKYL 107 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-SYQMALTPVVVTLWY 180 Q LR +D+LH+N I+HRD+KPENILV+ G KL DFG AR + V T WY Sbjct: 108 FQILRAIDYLHSNNIIHRDIKPENILVSQSGITKLCDFGFARTLAAPGDIYDDEVATRWY 167 Query: 181 RAPE-VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG--LPPEDD 237 RAPE VL ++Y PVD+W++GC+ EM P +S+ D L KI +G P + Sbjct: 168 RAPELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQN 227 Query: 238 WPRDVSLPRGAFPP--RGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 + G P + P+ + P++ A ++ L +P RIS+ L H Y Sbjct: 228 IFSKSPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYF 287 Query: 296 HKD 298 +D Sbjct: 288 TRD 290 >4FG9-A nrPDB Length = 320 Score = 254 bits (648), Expect = 4e-68, Method: Composition-based stats. Identities = 75/299 (25%), Positives = 125/299 (41%), Gaps = 41/299 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y+ +G GA+ V A D + VA+K + G G + E+A+L +++ Sbjct: 20 YDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSME----NEIAVLHKIK- 74 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGL-PAETIKDLMRQF 124 HPN+V L D+ + + L+ + V D+ G L+ Q Sbjct: 75 --HPNIVALDDIYESGG-----HLYLIMQLVSGG--ELFDRIVEKGFYTERDASRLIFQV 125 Query: 125 LRGLDFLHANCIVHRDLKPENIL---VTSGGTVKLADFGLARIYSYQMALTPVVVTLWYR 181 L + +LH IVHRDLKPEN+L + + ++DFGL+++ L+ T Y Sbjct: 126 LDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYV 185 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 APEVL Q Y+ VD WS+G I + P F ++A +I Sbjct: 186 APEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQIL-------------- 231 Query: 242 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 300 + + P ++ +S + ++ +P KR + +ALQH ++ D Sbjct: 232 ----KAEYEFDSP-----YWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTA 281 >5IG1-A nrPDB Length = 344 Score = 254 bits (648), Expect = 4e-68, Method: Composition-based stats. Identities = 69/293 (23%), Positives = 113/293 (38%), Gaps = 38/293 (12%) Query: 10 AEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHP 69 + IG GA+ TV++ + +G A+K + + + RE+ + L +H Sbjct: 23 SVIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEIN---KIKREIGICSSL---QHE 76 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 ++V + E LVFE+V + + + M Q L L Sbjct: 77 HIVSMRRAFRD-----ESHFYLVFEYVSGG-ELFDEIVTRKFYNEKDASACMHQILSALQ 130 Query: 130 FLHANCIVHRDLKPENILV---TSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVL 186 H+ I+HRDLKPEN+L+ VK+ DFGLA I T Y +PEV+ Sbjct: 131 HCHSKNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVI 190 Query: 187 LQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPR 246 + Y T VD+W+ G I + P F +I + P +W Sbjct: 191 RRVPYDTAVDVWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEW-------- 242 Query: 247 GAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE 299 + + +L+ ML NP +R + LQH ++ + + Sbjct: 243 ---------------DSVTTAAKELIKAMLEPNPKRRPTVQELLQHPWIARRD 280 >3Q5I-A nrPDB Length = 504 Score = 253 bits (647), Expect = 7e-68, Method: Composition-based stats. Identities = 76/304 (25%), Positives = 127/304 (41%), Gaps = 38/304 (12%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPN----GGGGGGGLPISTVREV-ALL 60 Y V ++G GAYG V ++ + A+K ++ E+ + Sbjct: 38 YFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFDKGRYSDDNKNIEKFHEEIYNEI 97 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 L++ +HPN+++L DV + LV E + + ++ Sbjct: 98 SLLKSLDHPNIIKLFDVFEDKK-----YFYLVTEFYEGG-ELFEQIINRHKFDECDAANI 151 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGG---TVKLADFGLARIYSYQMALTPVVVT 177 M+Q L G+ +LH + IVHRD+KPENIL+ + +K+ DFGL+ +S L + T Sbjct: 152 MKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVDFGLSSFFSKDYKLRDRLGT 211 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 +Y APEVL Y D+WS G I + P F G ++ D + K+ +D Sbjct: 212 AYYIAPEVLK-KKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFND 270 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 W + + +L+ MLT++ +KR +A AL ++ K Sbjct: 271 WK-----------------------NISDEAKELIKLMLTYDYNKRCTAEEALNSRWIKK 307 Query: 298 DEGN 301 N Sbjct: 308 YANN 311 >4REW-A nrPDB Length = 540 Score = 253 bits (646), Expect = 9e-68, Method: Composition-based stats. Identities = 81/300 (27%), Positives = 123/300 (41%), Gaps = 41/300 (13%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + Y +GVG +G V + +GH VA+K + I RE+ Sbjct: 3 VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIR--REIQ-- 58 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKD 119 L+ F HP++++L V +T + +V E+V L Y+ K L + + Sbjct: 59 -NLKLFRHPHIIKLYQVISTPSD-----IFMVMEYVSGGELFDYICKNGR--LDEKESRR 110 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLW 179 L +Q L G+D+ H + +VHRDLKPEN+L+ + K+ADFGL+ + S L + Sbjct: 111 LFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN 170 Query: 180 YRAPEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y APEV+ Y VD+WS G I + F + KI D I P+ Sbjct: 171 YAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQY-- 228 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + S LL ML +P KR S +H + +D Sbjct: 229 -------------------------LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQD 263 >3TAC-A nrPDB Length = 361 Score = 252 bits (645), Expect = 9e-68, Method: Composition-based stats. Identities = 81/301 (26%), Positives = 125/301 (41%), Gaps = 39/301 (12%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 YE IG G + V + + +G A+K V V G RE ++ L+ Sbjct: 28 YELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLK- 86 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGL--PAETIKDLMR 122 HP++V L++ ++ + +VFE +D DL + K G MR Sbjct: 87 --HPHIVELLETYSSDGM-----LYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMR 139 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLA-RIYSYQMALTPVVVTL 178 Q L L + H N I+HRD+KP +L+ S VKL FG+A ++ + V T Sbjct: 140 QILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTP 199 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 + APEV+ + Y PVD+W G I + F G E ++F+ I Sbjct: 200 HFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKE-----RLFEGIIKGKYKMN 254 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 PR S + ES L+ ML +P +RI+ + AL H +L + Sbjct: 255 PRQWS-------------------HISESAKDLVRRMLMLDPAERITVYEALNHPWLKER 295 Query: 299 E 299 + Sbjct: 296 D 296 >2JC6-A nrPDB Length = 334 Score = 252 bits (644), Expect = 1e-67, Method: Composition-based stats. Identities = 71/299 (23%), Positives = 125/299 (41%), Gaps = 41/299 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +E +G GA+ V A + +G A+K + G + E+A+LR+++ Sbjct: 24 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIE----NEIAVLRKIK- 78 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGL-PAETIKDLMRQF 124 H N+V L D+ + + LV + V D+ G + L+RQ Sbjct: 79 --HENIVALEDIYESPN-----HLYLVMQLVSGG--ELFDRIVEKGFYTEKDASTLIRQV 129 Query: 125 LRGLDFLHANCIVHRDLKPENILV---TSGGTVKLADFGLARIYSYQMALTPVVVTLWYR 181 L + +LH IVHRDLKPEN+L + ++DFGL+++ ++ T Y Sbjct: 130 LDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTPGYV 189 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 APEVL Q Y+ VD WS+G I + P F +++ +I Sbjct: 190 APEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQIL-------------- 235 Query: 242 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 300 + + P ++ +S + ++ +P+KR + +A +H ++ D Sbjct: 236 ----KAEYEFDSP-----YWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTA 285 >4LG4-A nrPDB Length = 299 Score = 251 bits (642), Expect = 2e-67, Method: Composition-based stats. Identities = 70/292 (23%), Positives = 128/292 (43%), Gaps = 40/292 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 ++ + ++G G+YG+V+KA SG VA+K V V + ++E++++++ ++ Sbjct: 13 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQ-------EIIKEISIMQQCDS 65 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 P VV+ + + +V E+ + + + L + I +++ L Sbjct: 66 ---PYVVKYYGSY-----FKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTL 117 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVV-VTLWYRAPE 184 +GL++LH +HR++K NIL+ + G KLADFG+A + MA V T ++ APE Sbjct: 118 KGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 177 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244 V+ + Y D+WS+G EM KP + + I Sbjct: 178 VIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMI------------------ 219 Query: 245 PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 P P P + + + L NP +R +A + LQH ++ Sbjct: 220 ------PTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK 265 >3SOA-A nrPDB Length = 444 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 81/302 (26%), Positives = 117/302 (38%), Gaps = 39/302 (12%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 T Y+ E+G GA+ V + +G A + RE + R Sbjct: 10 TEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARD---HQKLEREARICRL 66 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L+ HPN+VRL D + E L+F+ V + D ++ Sbjct: 67 LK---HPNIVRLHDSIS-----EEGHHYLIFDLVTGG-ELFEDIVAREYYSEADASHCIQ 117 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLA-RIYSYQMALTPVVVTL 178 Q L + H +VHR+LKPEN+L+ S G VKLADFGLA + Q A T Sbjct: 118 QILEAVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTP 177 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y +PEVL + Y PVD+W+ G I + P F + +I P +W Sbjct: 178 GYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEW 237 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + L+ +MLT NP KRI+A AL+H ++ Sbjct: 238 -----------------------DTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHR 274 Query: 299 EG 300 Sbjct: 275 ST 276 >6AO5-A nrPDB Length = 362 Score = 249 bits (636), Expect = 1e-66, Method: Composition-based stats. Identities = 70/292 (23%), Positives = 128/292 (43%), Gaps = 40/292 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 ++ + ++G G+YG+V+KA SG VA+K V V + ++E++++++ ++ Sbjct: 12 FDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQ-------EIIKEISIMQQCDS 64 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 P VV+ + + +V E+ + + + L + I +++ L Sbjct: 65 ---PYVVKYYGSY-----FKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTL 116 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVV-VTLWYRAPE 184 +GL++LH +HR++K NIL+ + G KLADFG+A + MA V T ++ APE Sbjct: 117 KGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPE 176 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244 V+ + Y D+WS+G EM KP + + I Sbjct: 177 VIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMI------------------ 218 Query: 245 PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 P P P + + + L NP +R +A + LQH ++ Sbjct: 219 ------PTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIK 264 >4CFH-A nrPDB Length = 493 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 80/300 (26%), Positives = 123/300 (41%), Gaps = 41/300 (13%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + Y +GVG +G V + +GH VA+K + I RE+ Sbjct: 30 VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIR--REIQ-- 85 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKD 119 L+ F HP++++L V +T + +V E+V L Y+ K L + + Sbjct: 86 -NLKLFRHPHIIKLYQVISTPSD-----IFMVMEYVSGGELFDYICKNGR--LDEKESRR 137 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLW 179 L +Q L G+D+ H + +VHRDLKPEN+L+ + K+ADFGL+ + S L + Sbjct: 138 LFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN 197 Query: 180 YRAPEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y APEV+ Y VD+WS G I + F + KI D I P+ Sbjct: 198 YAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQY-- 255 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + S LL ML +P KR + +H + +D Sbjct: 256 -------------------------LNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQD 290 >5YKS-A nrPDB Length = 377 Score = 247 bits (632), Expect = 3e-66, Method: Composition-based stats. Identities = 81/300 (27%), Positives = 123/300 (41%), Gaps = 42/300 (14%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y+ +G G + V AR +G VA+K + G VR ++ Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLATGHLFQEVR------CMKL 90 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQF 124 +HPN+VRL +V D + K+ L+ E D D+ Y+ K GL + K Q Sbjct: 91 VQHPNIVRLYEVI-----DTQTKLYLILELGDGGDMFDYIMKHE-EGLNEDLAKKYFAQI 144 Query: 125 LRGLDFLHANCIVHRDLKPEN-ILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183 + + + H +VHRDLKPEN + G VKL DFG + + LT +L Y AP Sbjct: 145 VHAISYCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAP 204 Query: 184 EVLLQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 E+LL Y P VD+WS+G I + +P F ++++ L I D P Sbjct: 205 EILLGDEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSH------ 258 Query: 243 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNP 302 + + L+ ML +P +R S H +L + +P Sbjct: 259 ---------------------VSKECKDLITRMLQRDPKRRASLEEIENHPWLQGVDPSP 297 >2J90-A nrPDB Length = 304 Score = 247 bits (632), Expect = 3e-66, Method: Composition-based stats. Identities = 72/302 (23%), Positives = 118/302 (39%), Gaps = 39/302 (12%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGL-PISTVREVAL 59 M YE E+G G + V K R +G A K ++ G+ REV + Sbjct: 23 MVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNI 82 Query: 60 LRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIK 118 LR + HPN++ L D+ + V L+ E V L +L A L + Sbjct: 83 LREIR---HPNIITLHDIFE-----NKTDVVLILELVSGGELFDFL--AEKESLTEDEAT 132 Query: 119 DLMRQFLRGLDFLHANCIVHRDLKPENILVTS----GGTVKLADFGLARIYSYQMALTPV 174 ++Q L G+ +LH+ I H DLKPENI++ +KL DFG+A + Sbjct: 133 QFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNI 192 Query: 175 VVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 T + APE++ DMWS+G I + F G ++ + L I + Sbjct: 193 FGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAV----- 247 Query: 235 EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294 + E + +L +P +R++ ++L+HS+ Sbjct: 248 ------------------NYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSW 289 Query: 295 LH 296 + Sbjct: 290 IK 291 >4RED-A nrPDB Length = 351 Score = 247 bits (631), Expect = 4e-66, Method: Composition-based stats. Identities = 81/300 (27%), Positives = 123/300 (41%), Gaps = 41/300 (13%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + Y +GVG +G V + +GH VA+K + I RE+ Sbjct: 11 VKIGHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIR--REIQ-- 66 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKD 119 L+ F HP++++L V +T + +V E+V L Y+ K L + + Sbjct: 67 -NLKLFRHPHIIKLYQVISTPSD-----IFMVMEYVSGGELFDYICKNGR--LDEKESRR 118 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLW 179 L +Q L G+D+ H + +VHRDLKPEN+L+ + K+ADFGL+ + S L + Sbjct: 119 LFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN 178 Query: 180 YRAPEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y APEV+ Y VD+WS G I + F + KI D I P+ Sbjct: 179 YAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQY-- 236 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + S LL ML +P KR S +H + +D Sbjct: 237 -------------------------LNPSVISLLKHMLQVDPMKRASIKDIREHEWFKQD 271 >4CFF-A nrPDB Length = 571 Score = 247 bits (631), Expect = 5e-66, Method: Composition-based stats. Identities = 78/300 (26%), Positives = 119/300 (39%), Gaps = 41/300 (13%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + Y +GVG +G V +GH VA+K + I RE+ Sbjct: 30 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIK--REIQ-- 85 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKD 119 L+ F HP++++L V +T +V E+V L Y+ K + + Sbjct: 86 -NLKLFRHPHIIKLYQVISTPTD-----FFMVMEYVSGGELFDYICKHGR--VEEMEARR 137 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLW 179 L +Q L +D+ H + +VHRDLKPEN+L+ + K+ADFGL+ + S L + Sbjct: 138 LFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN 197 Query: 180 YRAPEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y APEV+ Y VD+WS G I + F KI + PE Sbjct: 198 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY-- 255 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + S A LL+ ML +P KR + +H + +D Sbjct: 256 -------------------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQD 290 >3E3P-A nrPDB Length = 360 Score = 247 bits (630), Expect = 6e-66, Method: Composition-based stats. Identities = 93/313 (29%), Positives = 143/313 (45%), Gaps = 26/313 (8%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 R++ G G +GTV ++ +G VA+K V P RE+ +++ Sbjct: 22 MDRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKV---------IQDPRFRNRELQIMQD 72 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTL--VFEHVDQDL----RTYLDKAPPPGLPAET 116 L HPN+V+L T + L V E+V L R Y + P P Sbjct: 73 LAVLHHPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCCRNYYRRQVAP--PPIL 130 Query: 117 IKDLMRQFLRGLDFLH--ANCIVHRDLKPENILVTS-GGTVKLADFGLARIYSYQMALTP 173 IK + Q +R + LH + + HRD+KP N+LV GT+KL DFG A+ S Sbjct: 131 IKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDFGSAKKLSPSEPNVA 190 Query: 174 VVVTLWYRAPEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGL 232 + + +YRAPE++ Y T VD+WSVGCIFAEM +P+F G++ A QL +I ++G Sbjct: 191 YICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDNSAGQLHEIVRVLGC 250 Query: 233 PPEDDWPR-DVSLPRGAFPPRGPRPVQSVVPEME----ESGAQLLLEMLTFNPHKRISAF 287 P + + + S P +V + + LL +L + P +R+ + Sbjct: 251 PSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLSALLQYLPEERMKPY 310 Query: 288 RALQHSYLHKDEG 300 AL H Y + Sbjct: 311 EALCHPYFDELHD 323 >5ZTN-A nrPDB Length = 429 Score = 246 bits (629), Expect = 7e-66, Method: Composition-based stats. Identities = 92/334 (27%), Positives = 139/334 (41%), Gaps = 48/334 (14%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 RYE + IG G++G V KA D VALK VR E+ +L L Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKR------FHRQAAEEIRILEHLR 151 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 + N + ++ + + + FE + +L + K G ++ Sbjct: 152 KQDKDNTMNVIHMLENFTFRN--HICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSI 209 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGT--VKLADFGLARIYSYQMALTPVVVTLWYRA 182 L+ LD LH N I+H DLKPENIL+ G +K+ DFG + Y +Q T + + +YRA Sbjct: 210 LQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFG-SSCYEHQRVYT-YIQSRFYRA 267 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 PEV+L + Y P+DMWS+GCI AE+ PL G E DQL + +L+G+P + D Sbjct: 268 PEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLL--DA 325 Query: 243 SLPRGAFPPRGPRPVQSVVPEME----------------------------------ESG 268 S F P V + Sbjct: 326 SKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLF 385 Query: 269 AQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNP 302 L + L ++P R++ +AL+H +L + P Sbjct: 386 LDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKP 419 >5EZV-A nrPDB Length = 560 Score = 246 bits (628), Expect = 9e-66, Method: Composition-based stats. Identities = 78/300 (26%), Positives = 119/300 (39%), Gaps = 41/300 (13%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + Y +GVG +G V +GH VA+K + I RE+ Sbjct: 25 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIK--REIQ-- 80 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKD 119 L+ F HP++++L V +T +V E+V L Y+ K + + Sbjct: 81 -NLKLFRHPHIIKLYQVISTPTD-----FFMVMEYVSGGELFDYICKHGR--VEEMEARR 132 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLW 179 L +Q L +D+ H + +VHRDLKPEN+L+ + K+ADFGL+ + S L + Sbjct: 133 LFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPN 192 Query: 180 YRAPEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y APEV+ Y VD+WS G I + F KI + PE Sbjct: 193 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY-- 250 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + S A LL+ ML +P KR + +H + +D Sbjct: 251 -------------------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQD 285 >2Y7J-A nrPDB Length = 365 Score = 246 bits (628), Expect = 9e-66, Method: Composition-based stats. Identities = 81/304 (26%), Positives = 128/304 (42%), Gaps = 42/304 (13%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPI---STVREVALL 60 +Y+P IG G V + +GH A+K + V L +T RE +L Sbjct: 94 QKYDPKDVIGRGVSSVVRRCVHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHIL 153 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKD 119 R++ HP+++ L+D +S + LVF+ + +L YL + L + + Sbjct: 154 RQVAG--HPHIITLIDSYESSSF-----MFLVFDLMRKGELFDYLTE--KVALSEKETRS 204 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLW 179 +MR L + FLHAN IVHRDLKPENIL+ ++L+DFG + L + T Sbjct: 205 IMRSLLEAVSFLHANNIVHRDLKPENILLDDNMQIRLSDFGFSCHLEPGEKLRELCGTPG 264 Query: 180 YRAPEVLLQS------TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 233 Y APE+L S Y VD+W+ G I + P F + L I + Sbjct: 265 YLAPEILKCSMDETHPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQF 324 Query: 234 PEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHS 293 +W + + L+ +L +P R++A +ALQH Sbjct: 325 SSPEW-----------------------DDRSSTVKDLISRLLQVDPEARLTAEQALQHP 361 Query: 294 YLHK 297 + + Sbjct: 362 FFER 365 >2I6L-A nrPDB Length = 320 Score = 246 bits (628), Expect = 9e-66, Method: Composition-based stats. Identities = 98/309 (31%), Positives = 158/309 (51%), Gaps = 29/309 (9%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 SRY + +G G G V+ A D VA+K + + + +RE+ ++RRL Sbjct: 11 SRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVK-----HALREIKIIRRL 65 Query: 64 EAFEHPNVVRLMDVCATSRTD---------REIKVTLVFEHVDQDLRTYLDKAPPPGLPA 114 +H N+V++ ++ S + V +V E+++ DL L++ P L Sbjct: 66 ---DHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGP---LLE 119 Query: 115 ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARI----YSYQM 169 E + M Q LRGL ++H+ ++HRDLKP N+ + +K+ DFGLARI YS++ Sbjct: 120 EHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKG 179 Query: 170 ALTPVVVTLWYRAPEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD 228 L+ +VT WYR+P +LL + Y +DMW+ GCIFAEM K LF G E +Q+ I + Sbjct: 180 HLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILE 239 Query: 229 LIGLPPEDDWPRDVSLPRGAFPPR---GPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 I + E+D +S+ +P+ ++P + L ++LTF+P R++ Sbjct: 240 SIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDRLT 299 Query: 286 AFRALQHSY 294 A AL H Y Sbjct: 300 AEEALSHPY 308 >4UZD-A nrPDB Length = 287 Score = 245 bits (627), Expect = 1e-65, Method: Composition-based stats. Identities = 71/301 (23%), Positives = 121/301 (40%), Gaps = 39/301 (12%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 A +E +G G +G VY AR+ S +ALK + G+ REV + Sbjct: 6 ALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVL--FKAQLEKAGVEHQLRREVEIQS 63 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 L HPN++RL + +V L+ E+ Y + + + Sbjct: 64 HLR---HPNILRLYGYFHDA-----TRVYLILEYAPLGTV-YRELQKLSKFDEQRTATYI 114 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYR 181 + L + H+ ++HRD+KPEN+L+ S G +K+ADFG + +++ T + TL Y Sbjct: 115 TELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWS-VHAPSSRRTTLCGTLDYL 173 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 PE++ + VD+WS+G + E KP F N+ + +I + P Sbjct: 174 PPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFP------- 226 Query: 242 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGN 301 + E L+ +L NP +R L+H ++ + Sbjct: 227 --------------------DFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSK 266 Query: 302 P 302 P Sbjct: 267 P 267 >4NIF-A nrPDB Length = 333 Score = 245 bits (627), Expect = 1e-65, Method: Composition-based stats. Identities = 75/309 (24%), Positives = 125/309 (40%), Gaps = 44/309 (14%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + + Y IGVG+Y + + A+K + E+ +L Sbjct: 5 VFSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPS---------EEIEIL 55 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKD 119 L +HPN++ L DV D V LV E + +L + + Sbjct: 56 --LRYGQHPNIITLKDVY-----DDGKHVYLVTELMRGGELLDKILRQK--FFSEREASF 106 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENIL-VTSGGT---VKLADFGLARIYSYQMAL-TPV 174 ++ + +++LH+ +VHRDLKP NIL V G +++ DFG A+ + L Sbjct: 107 VLHTIGKTVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTP 166 Query: 175 VVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 T + APEVL + Y D+WS+G + M F N +D +I IG Sbjct: 167 CYTANFVAPEVLKRQGYDEGCDIWSLGILLYTMLAGYTPF-ANGPSDTPEEILTRIGS-- 223 Query: 235 EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294 G F G + E+ L+ +ML +PH+R++A + LQH + Sbjct: 224 ------------GKFTLSGGN-----WNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPW 266 Query: 295 LHKDEGNPE 303 + + + P+ Sbjct: 267 VTQKDKLPQ 275 >3H4J-B nrPDB Length = 336 Score = 245 bits (627), Expect = 1e-65, Method: Composition-based stats. Identities = 66/292 (22%), Positives = 118/292 (40%), Gaps = 40/292 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y +G G++G V A + VALK + + + RE++ L+ L Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISR--QLLKKSDMHMRVEREISYLKLLR- 67 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 HP++++L DV T + +V E+ +L Y+ + + + + +Q + Sbjct: 68 --HPHIIKLYDVITTPTD-----IVMVIEYAGGELFDYIVEKKR--MTEDEGRRFFQQII 118 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 +++ H + IVHRDLKPEN+L+ VK+ADFGL+ I + L + Y APEV Sbjct: 119 CAIEYCHRHKIVHRDLKPENLLLDDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEV 178 Query: 186 LLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244 + Y VD+WS G + M + F + K+ + + P Sbjct: 179 INGKLYAGPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMP---------- 228 Query: 245 PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 + L+ M+ +P +RI+ + + + Sbjct: 229 -----------------DFLSPGAQSLIRRMIVADPMQRITIQEIRRDPWFN 263 >3D2K-A nrPDB Length = 272 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 66/299 (22%), Positives = 120/299 (40%), Gaps = 39/299 (13%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 ++ +G G +G VY AR+ S +ALK + G+ REV + L Sbjct: 12 EDFDIGRPLGKGKFGNVYLARERQSKFILALKVL--FKTQLEKAGVEHQLRREVEIQSHL 69 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 HPN++RL + +V L+ E+ Y + + + + Sbjct: 70 R---HPNILRLYGYFHDA-----TRVYLILEYAPLGTV-YRELQKLSRFDEQRTATYITE 120 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183 L + H+ ++HRD+KPEN+L+ S G +K+ADFG + +++ T + TL Y P Sbjct: 121 LANALSYCHSKRVIHRDIKPENLLLGSNGELKIADFGWS-VHAPSSRRTTLCGTLDYLPP 179 Query: 184 EVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 E++ + VD+WS+G + E P F ++ + +I + P Sbjct: 180 EMIEGRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFP--------- 230 Query: 244 LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNP 302 + E L+ +L N +R++ L+H ++ + P Sbjct: 231 ------------------DFVTEGARDLISRLLKHNASQRLTLAEVLEHPWIKANSSKP 271 >2YAB-A nrPDB Length = 361 Score = 244 bits (624), Expect = 2e-65, Method: Composition-based stats. Identities = 74/297 (24%), Positives = 119/297 (40%), Gaps = 39/297 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGL-PISTVREVALLRRLE 64 Y+ E+G G + V K R+ +G A K ++ G+ REV++LR+ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIEREVSILRQ-- 71 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLMRQ 123 HPN++ L DV V L+ E V L +L A L E ++Q Sbjct: 72 -VLHPNIITLHDVYE-----NRTDVVLILELVSGGELFDFL--AQKESLSEEEATSFIKQ 123 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGG----TVKLADFGLARIYSYQMALTPVVVTLW 179 L G+++LH I H DLKPENI++ +KL DFGLA + + T Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 + APE++ DMWS+G I + F G+++ + L I + E+ Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEE--- 240 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 + E + ++L KR++ AL+H ++ Sbjct: 241 --------------------FFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWIT 277 >5XZW-A nrPDB Length = 471 Score = 244 bits (623), Expect = 3e-65, Method: Composition-based stats. Identities = 79/314 (25%), Positives = 134/314 (42%), Gaps = 54/314 (17%) Query: 4 SRYEPV-AEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + + +G GA+ TV KA + +G A+K + G G+ RE+ +L++ Sbjct: 195 KDFSIIDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKVIGNMDGVT----RELEVLQK 250 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLM 121 L HP +VRL + + +V E V DL ++ G + +++ Sbjct: 251 L---NHPRIVRLKGFYEDTES-----YYMVMEFVSGGDLMDFVAAHGAVG--EDAGREIS 300 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGT--VKLADFGLARIYSYQMALTPVVVTLW 179 RQ L + ++H+ I HRDLKP+NIL+ VK+ DFGLA++ + TL Sbjct: 301 RQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLA 360 Query: 180 YRAPEVLLQST-------------YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI 226 Y APEV+ Y++ VDMWS+GC+ + F G++ DQL K Sbjct: 361 YVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGST-QDQLYK- 418 Query: 227 FDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISA 286 + RG++ + + + E + +L +P+ R +A Sbjct: 419 ----------------QIGRGSYHEGPLKDFR-----ISEEARDFIDSLLQVDPNNRSTA 457 Query: 287 FRALQHSYLHKDEG 300 +AL H ++ Sbjct: 458 AKALNHPWIVDSSN 471 >4CZT-A nrPDB Length = 464 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 72/305 (23%), Positives = 124/305 (40%), Gaps = 44/305 (14%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 +YE +G G + V AR+ +G VA+K + + RE++ ++ + Sbjct: 11 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNK--MIAQIKREISTMKLI 68 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMR 122 + HPNV+R+ +V A+ + K+ V E V +L + L + + + Sbjct: 69 K---HPNVIRMFEVMAS-----KTKIYFVLEFVTGGELFDKISSNGR--LKEDEARKYFQ 118 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLA---RIYSYQMALTPVVVTLW 179 Q + +D+ H+ + HRDLKPEN+L+ + G +K++DFGL+ + L T Sbjct: 119 QLINAVDYCHSRGVYHRDLKPENLLLDANGALKVSDFGLSALPQQVREDGLLHTTCGTPN 178 Query: 180 YRAPEVLLQSTYA-TPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y APEV+ Y D+WS G I + F ++ KIF P Sbjct: 179 YVAPEVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCP---- 234 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 P S +L+ +L NP RI+ +++ + K Sbjct: 235 -----------------------PWFSASAKKLIKRILDPNPATRITFAEVIENEWFKKG 271 Query: 299 EGNPE 303 P+ Sbjct: 272 YKAPK 276 >1PHK-A nrPDB Length = 298 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 81/305 (26%), Positives = 119/305 (39%), Gaps = 43/305 (14%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVP----NGGGGGGGLPISTVREVAL 59 YEP +G G V + + A+K + V L +T++EV + Sbjct: 17 ENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEVQELREATLKEVDI 76 Query: 60 LRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIK 118 LR++ HPN+++L D T+ LVF+ + +L YL + L + + Sbjct: 77 LRKVSG--HPNIIQLKDTYETNTF-----FFLVFDLMKKGELFDYLTE--KVTLSEKETR 127 Query: 119 DLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTL 178 +MR L + LH IVHRDLKPENIL+ +KL DFG + L V T Sbjct: 128 KIMRALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEKLREVCGTP 187 Query: 179 WYRAPEVLLQS------TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGL 232 Y APE++ S Y VDMWS G I + P F + L I Sbjct: 188 SYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMS---- 243 Query: 233 PPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQH 292 G + P + ++ L+ L P KR +A AL H Sbjct: 244 --------------GNYQFGSPE-----WDDYSDTVKDLVSRFLVVQPQKRYTAEEALAH 284 Query: 293 SYLHK 297 + + Sbjct: 285 PFFQQ 289 >3GUB-A nrPDB Length = 295 Score = 242 bits (618), Expect = 1e-64, Method: Composition-based stats. Identities = 73/301 (24%), Positives = 127/301 (42%), Gaps = 39/301 (12%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGL-PISTVREVALLRRLE 64 Y+ E+G G + V K R+ +G A K ++ G+ REV++L+ + Sbjct: 13 YDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREVSILKEI- 71 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQ 123 +HPNV+ L +V + V L+ E V +L +L A L E + ++Q Sbjct: 72 --QHPNVITLHEVYE-----NKTDVILIGELVAGGELFDFL--AEKESLTEEEATEFLKQ 122 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGG----TVKLADFGLARIYSYQMALTPVVVTLW 179 L G+ +LH+ I H DLKPENI++ +K+ DFGLA + + T Sbjct: 123 ILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPE 182 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 + APE++ DMWS+G I + F G+++ + L + + ED++ Sbjct: 183 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANV-SAVNYEFEDEYF 241 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE 299 + S + +L +P KR++ +LQH ++ + Sbjct: 242 SNTSAL----------------------AKDFIRRLLVKDPKKRMTIQDSLQHPWIKPKD 279 Query: 300 G 300 Sbjct: 280 T 280 >2YCR-A nrPDB Length = 323 Score = 242 bits (617), Expect = 2e-64, Method: Composition-based stats. Identities = 69/302 (22%), Positives = 115/302 (38%), Gaps = 35/302 (11%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 Y +G GA G V A + + VA+K + G + + L Sbjct: 10 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETEIEIL 69 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 + HP ++++ + +V E ++ + L T K Q Sbjct: 70 KKLNHPCIIKIKNFFDAEDY------YIVLELMEGG-ELFDKVVGNKRLKEATCKLYFYQ 122 Query: 124 FLRGLDFLHANCIVHRDLKPENILVT---SGGTVKLADFGLARIYSYQMALTPVVVTLWY 180 L + +LH N I+HRDLKPEN+L++ +K+ DFG ++I + + T Y Sbjct: 123 MLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTY 182 Query: 181 RAPEVLLQ---STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 APEVL+ + Y VD WS+G I P F + L Sbjct: 183 LAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSL-------------- 228 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 ++ + F P V E+ E L+ ++L +P R + AL+H +L Sbjct: 229 -KDQITSGKYNFIP-------EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 280 Query: 298 DE 299 ++ Sbjct: 281 ED 282 >3EB0-A nrPDB Length = 383 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 89/341 (26%), Positives = 151/341 (44%), Gaps = 51/341 (14%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 ++ +Y +G G++G V + D SG ALK V P RE+ +++ Sbjct: 5 SSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKV---------LQDPRYKNRELDIMK 55 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREI---------------------------------K 88 L +H N+++L+D T+ + Sbjct: 56 VL---DHVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKY 112 Query: 89 VTLVFEHVDQDLRTYLDK--APPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENI 146 + ++ E+V L L +P I + Q R + F+H+ I HRD+KP+N+ Sbjct: 113 LNVIMEYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNL 172 Query: 147 LVTS-GGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQST-YATPVDMWSVGCIF 204 LV S T+KL DFG A+ + + +YRAPE++L +T Y +D+WS+GC+F Sbjct: 173 LVNSKDNTLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVF 232 Query: 205 AEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR-DVSLPRGAFPPRGPRPVQSVVPE 263 E+ KPLF G + DQL +I ++G P ++ R + FP + + ++PE Sbjct: 233 GELILGKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPE 292 Query: 264 MEES-GAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 303 S LL ++L + P RI+ + A+ H + + E Sbjct: 293 GTPSLAIDLLEQILRYEPDLRINPYEAMAHPFFDHLRNSYE 333 >2YZA-A nrPDB Length = 276 Score = 241 bits (615), Expect = 4e-64, Method: Composition-based stats. Identities = 78/300 (26%), Positives = 119/300 (39%), Gaps = 41/300 (13%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + Y +GVG +G V +GH VA+K + I RE+ Sbjct: 8 VKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIK--REIQ-- 63 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKD 119 L+ F HP++++L V +T +V E+V L Y+ K + + Sbjct: 64 -NLKLFRHPHIIKLYQVISTPTD-----FFMVMEYVSGGELFDYICKHGR--VEEMEARR 115 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLW 179 L +Q L +D+ H + +VHRDLKPEN+L+ + K+ADFGL+ + S L + Sbjct: 116 LFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRDSCGSPN 175 Query: 180 YRAPEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y APEV+ Y VD+WS G I + F KI + PE Sbjct: 176 YAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEY-- 233 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + S A LL+ ML +P KR + +H + +D Sbjct: 234 -------------------------LNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQD 268 >5D7A-A nrPDB Length = 308 Score = 240 bits (614), Expect = 4e-64, Method: Composition-based stats. Identities = 70/306 (22%), Positives = 116/306 (37%), Gaps = 41/306 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +E V +G G YG VYK R +G A+K + V G +E+ +L+ + Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVT------GDEEEEIKQEINMLK--KY 70 Query: 66 FEHPNVVRLMDVCATSRTDR-EIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQ 123 H N+ + ++ LV E + + L E I + R+ Sbjct: 71 SHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICRE 130 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRA 182 LRGL LH + ++HRD+K +N+L+T VKL DFG++ + + T ++ A Sbjct: 131 ILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMA 190 Query: 183 PEVLL-----QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 PEV+ +TY D+WS+G EM P C L I Sbjct: 191 PEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLI----------- 239 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 PR P P + + + L N +R + + ++H ++ Sbjct: 240 -------------PRNPAPRLK-SKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRD 285 Query: 298 DEGNPE 303 + Sbjct: 286 QPNERQ 291 >2W4O-A nrPDB Length = 349 Score = 240 bits (612), Expect = 6e-64, Method: Composition-based stats. Identities = 83/304 (27%), Positives = 134/304 (44%), Gaps = 45/304 (14%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVR-EVALLR 61 + +E +E+G GA VY+ + + ALK ++ + VR E+ +L Sbjct: 52 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKT--------VDKKIVRTEIGVLL 103 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDL 120 RL HPN+++L ++ T +++LV E V +L + D Sbjct: 104 RLS---HPNIIKLKEIFETP-----TEISLVLELVTGGELFDRI--VEKGYYSERDAADA 153 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVT 177 ++Q L + +LH N IVHRDLKPEN+L + +K+ADFGL++I +Q+ + V T Sbjct: 154 VKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGT 213 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 Y APE+L Y VDMWSVG I + F + DQ Sbjct: 214 PGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFY-DERGDQF-------------- 258 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 R + F E+ + L+ +++ +P KR++ F+ALQH ++ Sbjct: 259 MFRRILNCEYYFISPW-------WDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTG 311 Query: 298 DEGN 301 N Sbjct: 312 KAAN 315 >5ES1-A nrPDB Length = 328 Score = 240 bits (612), Expect = 7e-64, Method: Composition-based stats. Identities = 72/310 (23%), Positives = 118/310 (38%), Gaps = 50/310 (16%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 Y + IG G + V AR +G VA+K + REV +++ Sbjct: 15 GNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQ---KLFREVRIMK-- 69 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMR 122 HPN+V+L +V T +T + LV E+ ++ YL + + + R Sbjct: 70 -GLNHPNIVKLFEVIETEKT-----LYLVMEYASAGEVFDYLVSHGR--MKEKEARAKFR 121 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 Q + + + H IVHRDLK EN+L+ + +K+ADFG + ++ L + Y A Sbjct: 122 QIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAA 181 Query: 183 PEVLLQSTYA-TPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 PE+ Y VD+WS+G I + F G++ + Sbjct: 182 PELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKE-------------------- 221 Query: 242 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH----- 296 R R V M +L L NP KR + + ++ +++ Sbjct: 222 -------LRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEG 274 Query: 297 ---KDEGNPE 303 K PE Sbjct: 275 EELKPYTEPE 284 >2A27-A nrPDB Length = 321 Score = 239 bits (611), Expect = 8e-64, Method: Composition-based stats. Identities = 74/301 (24%), Positives = 119/301 (39%), Gaps = 39/301 (12%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGL-PISTVREVALLRRLE 64 Y+ E+G G + V K R+ +G A K ++ G+ REV++LR+ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQ-- 71 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLMRQ 123 H NV+ L DV V L+ E V L +L A L E ++Q Sbjct: 72 -VLHHNVITLHDVYE-----NRTDVVLILELVSGGELFDFL--AQKESLSEEEATSFIKQ 123 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGG----TVKLADFGLARIYSYQMALTPVVVTLW 179 L G+++LH I H DLKPENI++ +KL DFGLA + + T Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 + APE++ DMWS+G I + F G+++ + L I + E+ Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEE--- 240 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE 299 + E + ++L KR++ AL+H ++ + Sbjct: 241 --------------------FFSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVD 280 Query: 300 G 300 Sbjct: 281 N 281 >1ZWS-A nrPDB Length = 288 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 74/301 (24%), Positives = 118/301 (39%), Gaps = 39/301 (12%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGL-PISTVREVALLRRLE 64 Y+ E+G G + V K R+ +G A K ++ G+ REV++LR+ Sbjct: 14 YDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIEREVSILRQ-- 71 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLMRQ 123 H NV+ L DV V L+ E V L +L A L E ++Q Sbjct: 72 -VLHHNVITLHDVYE-----NRTDVVLILELVSGGELFDFL--AQKESLSEEEATSFIKQ 123 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGG----TVKLADFGLARIYSYQMALTPVVVTLW 179 L G+++LH I H DLKPENI++ +KL DFGLA + + T Sbjct: 124 ILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPE 183 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 + APE++ DMWS+G I + F G+++ + L I + E+ Sbjct: 184 FVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEE--- 240 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE 299 E + ++L KR++ AL+H ++ + Sbjct: 241 --------------------FFSHTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVD 280 Query: 300 G 300 Sbjct: 281 N 281 >3I6U-A nrPDB Length = 419 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 68/302 (22%), Positives = 115/302 (38%), Gaps = 35/302 (11%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 Y +G GA G V A + + VA++ + G + + L Sbjct: 135 DEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETEIEIL 194 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 + HP ++++ + +V E ++ + L T K Q Sbjct: 195 KKLNHPCIIKIKNFFDAEDY------YIVLELMEGG-ELFDKVVGNKRLKEATCKLYFYQ 247 Query: 124 FLRGLDFLHANCIVHRDLKPENILVT---SGGTVKLADFGLARIYSYQMALTPVVVTLWY 180 L + +LH N I+HRDLKPEN+L++ +K+ DFG ++I + + T Y Sbjct: 248 MLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPTY 307 Query: 181 RAPEVLLQ---STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 APEVL+ + Y VD WS+G I P F + L Sbjct: 308 LAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSL-------------- 353 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 ++ + F P V E+ E L+ ++L +P R + AL+H +L Sbjct: 354 -KDQITSGKYNFIP-------EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 405 Query: 298 DE 299 ++ Sbjct: 406 ED 407 >2JAM-A nrPDB Length = 304 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 71/299 (23%), Positives = 125/299 (41%), Gaps = 43/299 (14%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 + + +G GA+ V+ + +G ALK ++ S E+A+L++++ Sbjct: 11 FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKK-----SPAFRDSSLENEIAVLKKIK- 64 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLMRQF 124 H N+V L D+ ++ LV + V L + + + +++Q Sbjct: 65 --HENIVTLEDIYEST-----THYYLVMQLVSGGELFDRILERG--VYTEKDASLVIQQV 115 Query: 125 LRGLDFLHANCIVHRDLKPENILV---TSGGTVKLADFGLARIYSYQMALTPVVVTLWYR 181 L + +LH N IVHRDLKPEN+L + + DFGL++ ++ T Y Sbjct: 116 LSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSK-MEQNGIMSTACGTPGYV 174 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 APEVL Q Y+ VD WS+G I + P F +E+ KI + Sbjct: 175 APEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKE------------- 221 Query: 242 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 300 G + P ++ ES + +L +P++R + +AL H ++ + Sbjct: 222 -----GYYEFESP-----FWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTA 270 >5JZN-A nrPDB Length = 280 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 76/300 (25%), Positives = 127/300 (42%), Gaps = 42/300 (14%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 T RY+ IG G + V + + + ALK ++ G EV++LRR Sbjct: 18 TERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGK----EHMIQNEVSILRR 73 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLM 121 ++ HPN+V L++ D ++ LV E V DL + ++ Sbjct: 74 VK---HPNIVLLIE-----EMDVPTELYLVMELVKGGDLFDAITSTNK--YTERDASGML 123 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILV----TSGGTVKLADFGLARIYSYQMALTPVVVT 177 + +LH+ IVHRD+KPEN+LV ++KL DFGLA I L V T Sbjct: 124 YNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIV--DGPLYTVCGT 181 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 Y APE++ ++ Y VD+W+ G I + P F G+ + ++ Sbjct: 182 PTYVAPEIIAETGYGLKVDIWAAGVITYILLCGFPPFRGSGDD--------------QEV 227 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 + + + FP + +S +L+ ML + +R SA + L+H +++ Sbjct: 228 LFDQILMGQVDFPSP-------YWDNVSDSAKELITMMLLVDVDQRFSAVQVLEHPWVND 280 >1NY3-A nrPDB Length = 400 Score = 236 bits (603), Expect = 8e-63, Method: Composition-based stats. Identities = 75/306 (24%), Positives = 122/306 (39%), Gaps = 37/306 (12%) Query: 3 TSRYEPV-AEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 Y+ +G+G G V + + + ALK + REV L Sbjct: 60 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML----------QDCPKARREVELHW 109 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDL 120 R A + P++VR++DV R+ + +V E +D L + + ++ Sbjct: 110 R--ASQCPHIVRIVDVYENLYAGRKC-LLIVMECLDGGELFSRIQDRGDQAFTEREASEI 166 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVT 177 M+ + +LH+ I HRD+KPEN+L TS +KL DFG A+ + +LT T Sbjct: 167 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 226 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 +Y APEVL Y DMWS+G I + P F N GL Sbjct: 227 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------------GLAISPG 274 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 + + + FP E+ E L+ +L P +R++ + H ++ + Sbjct: 275 MKTRIRMGQYEFPNPE-------WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 327 Query: 298 DEGNPE 303 P+ Sbjct: 328 STKVPQ 333 >4JG6-A nrPDB Length = 355 Score = 236 bits (603), Expect = 9e-63, Method: Composition-based stats. Identities = 73/307 (23%), Positives = 122/307 (39%), Gaps = 44/307 (14%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 T YE +IGVG+Y + + A+K + E+ +L Sbjct: 34 TDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPT---------EEIEIL-- 82 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLM 121 L +HPN++ L DV D V +V E + +L + + ++ Sbjct: 83 LRYGQHPNIITLKDVY-----DDGKYVYVVTELMKGGELLDKILRQK--FFSEREASAVL 135 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGG----TVKLADFGLARIYSYQMAL-TPVVV 176 + +++LHA +VHRDLKP NIL ++++ DFG A+ + L Sbjct: 136 FTITKTVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCY 195 Query: 177 TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPED 236 T + APEVL + Y D+WS+G + M F N D +I IG Sbjct: 196 TANFVAPEVLERQGYDAACDIWSLGVLLYTMLTGYTPF-ANGPDDTPEEILARIGS---- 250 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 G F G + ++ L+ +ML +PH+R++A L+H ++ Sbjct: 251 ----------GKFSLSGG-----YWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIV 295 Query: 297 KDEGNPE 303 + P+ Sbjct: 296 HWDQLPQ 302 >4KS7-A nrPDB Length = 292 Score = 236 bits (602), Expect = 9e-63, Method: Composition-based stats. Identities = 79/294 (26%), Positives = 128/294 (43%), Gaps = 41/294 (13%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +IG G+ G V AR+ HSG VA+K + + EV ++R ++H N Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRR-----ELLFNEVVIMR---DYQHFN 81 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 VV + ++ ++ E + T + L E I + L+ L + Sbjct: 82 VVEMYKSYLVGE-----ELWVLMEFLQGGALTDIVSQ--VRLNEEQIATVCEAVLQALAY 134 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPEVLLQS 189 LHA ++HRD+K ++IL+T G VKL+DFG S + +V T ++ APEV+ +S Sbjct: 135 LHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRS 194 Query: 190 TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAF 249 YAT VD+WS+G + EM +P + +S + ++ D Sbjct: 195 LYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRD--------------------- 233 Query: 250 PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 303 P P ++ L ML +P +R +A L H +L + G PE Sbjct: 234 ---SPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQ-TGLPE 283 >2QNJ-A nrPDB Length = 328 Score = 236 bits (602), Expect = 9e-63, Method: Composition-based stats. Identities = 69/303 (22%), Positives = 115/303 (37%), Gaps = 42/303 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 Y + IG G + V AR +G VA+K + REV +++ Sbjct: 11 IGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQ---KLFREVRIMKI 67 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLM 121 L HPN+V+L +V T +T + L+ E+ + YL + + + Sbjct: 68 L---NHPNIVKLFEVIETEKT-----LYLIMEYASGGEVFDYL--VAHGRMKEKEARSKF 117 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYR 181 RQ + + + H IVHRDLK EN+L+ + +K+ADFG + ++ L + Y Sbjct: 118 RQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYA 177 Query: 182 APEVLLQSTYA-TPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 APE+ Y VD+WS+G I + F G + + ++ P Sbjct: 178 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFY---- 233 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 300 M LL L NP KR + + ++ +++ Sbjct: 234 -----------------------MSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHE 270 Query: 301 NPE 303 E Sbjct: 271 EDE 273 >6FD3-A nrPDB Length = 300 Score = 236 bits (602), Expect = 1e-62, Method: Composition-based stats. Identities = 76/297 (25%), Positives = 125/297 (42%), Gaps = 40/297 (13%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 +Y +IG GA GTVY A D +G VA+K + + + E+ ++R Sbjct: 22 KKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKK-----ELIINEILVMRE- 75 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 ++PN+V +D ++ +V E++ T D + I + R+ Sbjct: 76 --NKNPNIVNYLDSYLVGD-----ELWVVMEYLAGGSLT--DVVTETCMDEGQIAAVCRE 126 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRA 182 L+ LDFLH+N ++HRD+K +NIL+ G+VKL DFG + + + +V T ++ A Sbjct: 127 CLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMA 186 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 PEV+ + Y VD+WS+G + EM +P + + L I Sbjct: 187 PEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIA--------------- 231 Query: 243 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE 299 P + L L + +R SA LQH +L D+ Sbjct: 232 ---------TNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLDK 279 >3KA0-A nrPDB Length = 320 Score = 235 bits (601), Expect = 1e-62, Method: Composition-based stats. Identities = 75/306 (24%), Positives = 122/306 (39%), Gaps = 37/306 (12%) Query: 3 TSRYEPV-AEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 Y+ +G+G G V + + + ALK + REV L Sbjct: 14 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML----------QDCPKARREVELHW 63 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDL 120 R A + P++VR++DV R+ + +V E +D L + + ++ Sbjct: 64 R--ASQCPHIVRIVDVYENLYAGRKC-LLIVMECLDGGELFSRIQDRGDQAFTEREASEI 120 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVT 177 M+ + +LH+ I HRD+KPEN+L TS +KL DFG A+ + +LT T Sbjct: 121 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYT 180 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 +Y APEVL Y DMWS+G I + P F N GL Sbjct: 181 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------------GLAISPG 228 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 + + + FP E+ E L+ +L P +R++ + H ++ + Sbjct: 229 MKTRIRMGQYEFPNPE-------WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 281 Query: 298 DEGNPE 303 P+ Sbjct: 282 STKVPQ 287 >2UV2-A nrPDB Length = 325 Score = 235 bits (601), Expect = 1e-62, Method: Composition-based stats. Identities = 73/303 (24%), Positives = 122/303 (40%), Gaps = 43/303 (14%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +E + E+G GA+G VYKA++ + A K + + + E+ + L + Sbjct: 39 WEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYMV-----EIDI---LAS 90 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 +HPN+V+L+D E + ++ E + L I+ + +Q L Sbjct: 91 CDHPNIVKLLDAFY-----YENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTL 145 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALT-PVVVTLWYRAPE 184 L++LH N I+HRDLK NIL T G +KLADFG++ + + + T ++ APE Sbjct: 146 DALNYLHDNKIIHRDLKAGNILFTLDGDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPE 205 Query: 185 VLL-----QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 V++ Y D+WS+G EM +P + L KI Sbjct: 206 VVMCETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELNPMRVLLKIA------------ 253 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE 299 + P + + L + L N R + + LQH ++ D Sbjct: 254 ------------KSEPPTLAQPSRWSSNFKDFLKKCLEKNVDARWTTSQLLQHPFVTVDS 301 Query: 300 GNP 302 P Sbjct: 302 NKP 304 >2OZA-A nrPDB Length = 356 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 75/306 (24%), Positives = 122/306 (39%), Gaps = 37/306 (12%) Query: 3 TSRYEPV-AEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 Y+ +G+G G V + + + ALK + REV L Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML----------QDCPKARREVELHW 65 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDL 120 R A + P++VR++DV R+ + +V E +D L + + ++ Sbjct: 66 R--ASQCPHIVRIVDVYENLYAGRKC-LLIVMECLDGGELFSRIQDRGDQAFTEREASEI 122 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVT 177 M+ + +LH+ I HRD+KPEN+L TS +KL DFG A+ + +LT T Sbjct: 123 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYT 182 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 +Y APEVL Y DMWS+G I + P F N GL Sbjct: 183 PYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------------GLAISPG 230 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 + + + FP E+ E L+ +L P +R++ + H ++ + Sbjct: 231 MKTRIRMGQYEFPNPE-------WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 283 Query: 298 DEGNPE 303 P+ Sbjct: 284 STKVPQ 289 >4PDS-A nrPDB Length = 347 Score = 235 bits (599), Expect = 2e-62, Method: Composition-based stats. Identities = 77/310 (24%), Positives = 134/310 (43%), Gaps = 54/310 (17%) Query: 4 SRYEPV-AEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + + +G GA+ TV KA + +G ++K + G G+ RE+ +L++ Sbjct: 30 KDFSIIDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKVIGNMDGVT----RELEVLQK 85 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLM 121 L HP +VRL + + +V E V DL ++ A + + +++ Sbjct: 86 L---NHPRIVRLKGFYEDTES-----YYMVMEFVSGGDLMDFV--AAHGAVGEDAGREIS 135 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGT--VKLADFGLARIYSYQMALTPVVVTLW 179 RQ L + ++H+ I HRDLKP+NIL+ VK+ FGLA++ + TL Sbjct: 136 RQILTAIKYIHSMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLA 195 Query: 180 YRAPEVLLQST-------------YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI 226 Y APEV+ Y++ VDMWS+GC+ + F G++ DQL K Sbjct: 196 YVAPEVIRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGST-QDQLYK- 253 Query: 227 FDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISA 286 + RG++ + + + E + +L +P+ R +A Sbjct: 254 ----------------QIGRGSYHEGPLKDFR-----ISEEARDFIDSLLQVDPNNRSTA 292 Query: 287 FRALQHSYLH 296 +AL H ++ Sbjct: 293 AKALNHPWIK 302 >5WAX-A nrPDB Length = 310 Score = 235 bits (599), Expect = 2e-62, Method: Composition-based stats. Identities = 71/299 (23%), Positives = 112/299 (37%), Gaps = 41/299 (13%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 RYE V +IG G +G R+ G VA+K + G + + RE+ R L Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYI------ERGEKIDENVQREIINHRSL 64 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 HPN++R +V T + +V E+ + + + +Q Sbjct: 65 R---HPNIIRFKEVILTP-----THLAIVMEYASGG-ELFERICNAGRFSEDEARFFFQQ 115 Query: 124 FLRGLDFLHANCIVHRDLKPENILVT--SGGTVKLADFGLARIYSYQMALTPVVVTLWYR 181 + G+ + H+ + HRDLK EN L+ + +K+ DFG ++ V T Y Sbjct: 116 LISGVSYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYI 175 Query: 182 APEVLLQSTYATPV-DMWSVGCIFAEMFRRKPLFCGNSEADQLGK-IFDLIGLPPEDDWP 239 APEVLL+ Y V D+WS G M F E K I ++G+ Sbjct: 176 APEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGV------- 228 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 S+P + L+ + NP RI+ H + K+ Sbjct: 229 -QYSIPDYV--------------HISPECQDLISRIFVANPATRITIPEIRNHPWFLKN 272 >3F3Z-A nrPDB Length = 277 Score = 234 bits (598), Expect = 3e-62, Method: Composition-based stats. Identities = 67/296 (22%), Positives = 114/296 (38%), Gaps = 41/296 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y IG G++G V A + A K + +E+ +++ L Sbjct: 11 YTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVD-----RFKQEIEIMKSL-- 63 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 +HPN++RL + + + LV E + +M+ L Sbjct: 64 -DHPNIIRLYETFEDNTD-----IYLVMELCTGG-ELFERVVHKRVFRESDAARIMKDVL 116 Query: 126 RGLDFLHANCIVHRDLKPENILV---TSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 + + H + HRDLKPEN L + +KL DFGLA + + V T +Y + Sbjct: 117 SAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGTPYYVS 176 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 P+VL + Y D WS G + + P F ++++ + KI + PE DW Sbjct: 177 PQVL-EGLYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEKDWL--- 232 Query: 243 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + L+ +LT +P +RI++ +AL+H + K Sbjct: 233 --------------------NVSPQAESLIRRLLTKSPKQRITSLQALEHEWFEKQ 268 >5KZ7-A nrPDB Length = 346 Score = 234 bits (597), Expect = 4e-62, Method: Composition-based stats. Identities = 69/296 (23%), Positives = 116/296 (39%), Gaps = 42/296 (14%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 Y + IG G + V AR +G VA+K + REV +++ Sbjct: 32 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQ---KLFREVRIMKV 88 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLM 121 L HPN+V+L +V T +T + LV E+ + YL + + + Sbjct: 89 L---NHPNIVKLFEVIETEKT-----LYLVMEYASGGEVFDYL--VAHGRMKEKEARAKF 138 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYR 181 RQ + + + H IVHRDLK EN+L+ + +K+ADFG + +++ L + Y Sbjct: 139 RQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYA 198 Query: 182 APEVLLQSTYA-TPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 APE+ Y VD+WS+G I + F G + + ++ P Sbjct: 199 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFY---- 254 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 M LL + L NP KR + + ++ +++ Sbjct: 255 -----------------------MSTDCENLLKKFLILNPSKRGTLEQIMKDRWMN 287 >3FXW-A nrPDB Length = 336 Score = 233 bits (595), Expect = 6e-62, Method: Composition-based stats. Identities = 73/307 (23%), Positives = 124/307 (40%), Gaps = 38/307 (12%) Query: 2 ATSRYEP-VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 T Y+ +G+G G V + +G ALK + +EV Sbjct: 26 VTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL----------YDSPKARQEVDHH 75 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKD 119 + P++V ++DV + + ++ E ++ L + + + + Sbjct: 76 WQASGG--PHIVCILDVYENMHHGKRC-LLIIMECMEGGELFSRIQERGDQAFTEREAAE 132 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVV 176 +MR + FLH++ I HRD+KPEN+L TS +KL DFG A+ + TP Sbjct: 133 IMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTP-CY 191 Query: 177 TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPED 236 T +Y APEVL Y DMWS+G I + P F N+ G Sbjct: 192 TPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGFPPFYSNT------------GQAISP 239 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 R + L + FP E+ E QL+ +L +P +R++ + + H +++ Sbjct: 240 GMKRRIRLGQYGFPNPE-------WSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWIN 292 Query: 297 KDEGNPE 303 + P+ Sbjct: 293 QSMVVPQ 299 >2F57-A nrPDB Length = 317 Score = 233 bits (594), Expect = 9e-62, Method: Composition-based stats. Identities = 75/287 (26%), Positives = 123/287 (42%), Gaps = 40/287 (13%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +IG G+ G V A + H+G VA+K + + EV ++R + H N Sbjct: 52 KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRR-----ELLFNEVVIMR---DYHHDN 103 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 VV + ++ +V E ++ T + + E I + LR L + Sbjct: 104 VVDMYSSYLVGD-----ELWVVMEFLEGGALTDI--VTHTRMNEEQIATVCLSVLRALSY 156 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPEVLLQS 189 LH ++HRD+K ++IL+TS G +KL+DFG S ++ +V T ++ APEV+ + Sbjct: 157 LHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRL 216 Query: 190 TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAF 249 Y T VD+WS+G + EM +P + + +I D + P D + S+ RG Sbjct: 217 PYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSL-PPRVKDLHKVSSVLRG-- 273 Query: 250 PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 L ML P +R +A L H +L Sbjct: 274 ---------------------FLDLMLVREPSQRATAQELLGHPFLK 299 >3IS5-A nrPDB Length = 285 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 72/298 (24%), Positives = 118/298 (39%), Gaps = 43/298 (14%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 + ++G GA+G V+ + SG +K++ + E+ +L+ L Sbjct: 24 FIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPMEQIEA----EIEVLKSL-- 77 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPG--LPAETIKDLMR 122 +HPN++++ +V + +V E + L + A G L + +LM+ Sbjct: 78 -DHPNIIKIFEVFEDYHN-----MYIVMETCEGGELLERIVSAQARGKALSEGYVAELMK 131 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTLW 179 Q + L + H+ +VH+DLKPENIL +K+ DFGLA ++ T T Sbjct: 132 QMMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTAL 191 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 Y APEV + D+WS G + + F G S + K Sbjct: 192 YMAPEVFKRDV-TFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQK-------------- 236 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 P A R P LL +MLT +P +R SA + L H + + Sbjct: 237 ATYKEPNYAVECRPLTP----------QAVDLLKQMLTKDPERRPSAAQVLHHEWFKQ 284 >4D28-A nrPDB Length = 446 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 73/299 (24%), Positives = 117/299 (39%), Gaps = 42/299 (14%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 +YE IG G + V AR+ +G VA+K + + RE+++++ Sbjct: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIM--AKSTILKNRMVDQIKREISIMK-- 64 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMR 122 HPN+VRL +V A+ + K+ +V E V +L + L + + + Sbjct: 65 -IVRHPNIVRLYEVLAS-----KSKIYIVLEFVTGGELFDRI--VHKGRLKEDESRKYFQ 116 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-LTPVVVTLWYR 181 Q + + H+ + HRDLKPEN+L+ + G +K++DFGL+ + + L T Y Sbjct: 117 QLVDAVAHCHSKGVYHRDLKPENLLLDTNGNLKVSDFGLSALPQEGVELLNDTCGTPNYV 176 Query: 182 APEVLLQSTYA-TPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 APEVL Y + D+WS G I + F KI E D P Sbjct: 177 APEVLSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAA-----EFDCP- 230 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE 299 P L+ +L NP RI + + K+ Sbjct: 231 ---------------------PWFSAEVKFLIHRILDPNPKTRIQIQGIKKDPWFRKNY 268 >4QMW-A nrPDB Length = 310 Score = 232 bits (591), Expect = 2e-61, Method: Composition-based stats. Identities = 70/297 (23%), Positives = 129/297 (43%), Gaps = 41/297 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 + + +IG G++G V+K D + VA+K + + + +E+ +L + ++ Sbjct: 31 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQ----QEITVLSQCDS 86 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 P V + ++ K+ ++ E++ + LD P L I ++R+ L Sbjct: 87 ---PYVTKYYGSYL-----KDTKLWIIMEYLGGG--SALDLLEPGPLDETQIATILREIL 136 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY-QMALTPVVVTLWYRAPE 184 +GLD+LH+ +HRD+K N+L++ G VKLADFG+A + Q+ V T ++ APE Sbjct: 137 KGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE 196 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244 V+ QS Y + D+WS+G E+ R +P L I Sbjct: 197 VIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLI------------------ 238 Query: 245 PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGN 301 P P ++ + + + L P R +A L+H ++ ++ Sbjct: 239 -----PKNNPPTLEGNY---SKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKK 287 >4FIE-A nrPDB Length = 423 Score = 231 bits (590), Expect = 2e-61, Method: Composition-based stats. Identities = 71/288 (24%), Positives = 122/288 (42%), Gaps = 40/288 (13%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +IG G+ G V A SG VA+K + + EV ++R ++H N Sbjct: 158 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR-----ELLFNEVVIMR---DYQHEN 209 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 VV + + ++ +V E ++ T + + E I + L+ L Sbjct: 210 VVEMYNSYLVGD-----ELWVVMEFLEGGALTDI--VTHTRMNEEQIAAVCLAVLQALSV 262 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPEVLLQS 189 LHA ++HRD+K ++IL+T G VKL+DFG S ++ +V T ++ APE++ + Sbjct: 263 LHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL 322 Query: 190 TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAF 249 Y VD+WS+G + EM +P + + I D + Sbjct: 323 PYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL------------------- 363 Query: 250 PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 P + + V P + L +L +P +R +A L+H +L K Sbjct: 364 -PPRLKNLHKVSPSL----KGFLDRLLVRDPAQRATAAELLKHPFLAK 406 >3UTO-A nrPDB Length = 573 Score = 231 bits (589), Expect = 3e-61, Method: Composition-based stats. Identities = 67/295 (22%), Positives = 116/295 (39%), Gaps = 38/295 (12%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 Y+ E+G GA+G V++ + +G+ A K V P+ + +E+ + L Sbjct: 157 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDK-----ETVRKEIQTMSVL 211 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 HP +V L D ++ +++E + + + + MRQ Sbjct: 212 R---HPTLVNLHDAFEDDN-----EMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQ 263 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTS--GGTVKLADFGLARIYSYQMALTPVVVTLWYR 181 +GL +H N VH DLKPENI+ T+ +KL DFGL + ++ T + Sbjct: 264 VCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFA 323 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 APEV DMWSVG + + F G ++ + L + Sbjct: 324 APEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSC------------ 371 Query: 242 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 S + E G + ++L +P+ R++ +AL+H +L Sbjct: 372 -----------DWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLT 415 >4CSV-A nrPDB Length = 275 Score = 231 bits (589), Expect = 3e-61, Method: Composition-based stats. Identities = 62/288 (21%), Positives = 124/288 (43%), Gaps = 44/288 (15%) Query: 8 PVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 ++G G +G VY+ + + VA+K+++ G ++E ++++L+ Sbjct: 15 LERKLGSGQFGEVYEGKWRNYNIEVAVKTLK------EGTMSVEEFLQEAQIMKKLK--- 65 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLR 126 HPN+V+L VC +E + ++ E++ L YL + A+ + D+ Q Sbjct: 66 HPNLVQLYGVCT-----KEPPIYIITEYMSHGSLLDYLRDCEGHTVNAQALLDMAAQVAS 120 Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ--MALTPVVVTLWYRAPE 184 G+ +L + +HRDL N LV VK+ADFGLAR+ + A + + APE Sbjct: 121 GMAYLESQNFIHRDLAARNCLVGENNVVKVADFGLARLINEDEYTARAGAKFPIKWTAPE 180 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 + + ++ D+W+ G + E+F + + G S ++ + ++ +P P ++ Sbjct: 181 AISYNRFSIKSDVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCPEEIY 240 Query: 244 LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 +L+L+ +P +R + L Sbjct: 241 --------------------------ELMLQCWNKSPEERPTFAETLH 262 >2X4F-A nrPDB Length = 373 Score = 230 bits (587), Expect = 5e-61, Method: Composition-based stats. Identities = 72/290 (24%), Positives = 116/290 (40%), Gaps = 38/290 (13%) Query: 10 AEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHP 69 +G G +G V+K + +G +A K ++ G E++++ +L +H Sbjct: 95 EILGGGRFGQVHKCEETATGLKLAAKIIKT-----RGMKDKEEVKNEISVMNQL---DHA 146 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 N+++L D + + LV E+VD L M+Q G+ Sbjct: 147 NLIQLYDAFESKND-----IVLVMEYVDGGELFDRIIDESYNLTELDTILFMKQICEGIR 201 Query: 130 FLHANCIVHRDLKPENILVTSG--GTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLL 187 +H I+H DLKPENIL + +K+ DFGLAR Y + L T + APEV+ Sbjct: 202 HMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGTPEFLAPEVVN 261 Query: 188 QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRG 247 + P DMWSVG I + F G+++A+ L I Sbjct: 262 YDFVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILAC------------------ 303 Query: 248 AFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 ++ E + + ++L RISA AL+H +L Sbjct: 304 -----RWDLEDEEFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSD 348 >2WO6-A nrPDB Length = 382 Score = 230 bits (587), Expect = 5e-61, Method: Composition-based stats. Identities = 93/340 (27%), Positives = 143/340 (42%), Gaps = 51/340 (15%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 RYE + IG G++G V KA D +VA+K ++ + EV LL Sbjct: 53 MDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI------EVRLLEL 106 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 + +H ++ V + LVFE + +L L G+ + + Sbjct: 107 MN--KHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQ 164 Query: 123 QFLRGLDFLH--ANCIVHRDLKPENILVTS--GGTVKLADFGLARIYSYQMALTPVVVTL 178 Q L FL I+H DLKPENIL+ + +K+ DFG + + + + Sbjct: 165 QMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQL--GQRIYQYIQSR 222 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 +YR+PEVLL Y +DMWS+GCI EM +PLF G +E DQ+ KI +++G+PP Sbjct: 223 FYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHIL 282 Query: 239 PRDVSL-------------------PRGAFPPRGPRPVQSVV---------PEMEESG-- 268 + + + P G R + +++ ESG Sbjct: 283 DQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHT 342 Query: 269 -------AQLLLEMLTFNPHKRISAFRALQHSYLHKDEGN 301 L+L ML ++P RI + ALQHS+ K Sbjct: 343 VADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADE 382 >2XIK-A nrPDB Length = 294 Score = 230 bits (586), Expect = 7e-61, Method: Composition-based stats. Identities = 72/297 (24%), Positives = 128/297 (43%), Gaps = 41/297 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 + + IG G++G VYK D H+ VA+K + + + +E+ +L + ++ Sbjct: 21 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQ----QEITVLSQCDS 76 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 P + R S K+ ++ E++ + LD P L I ++R+ L Sbjct: 77 ---PYITRYFGSYLKS-----TKLWIIMEYLGGG--SALDLLKPGPLEETYIATILREIL 126 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY-QMALTPVVVTLWYRAPE 184 +GLD+LH+ +HRD+K N+L++ G VKLADFG+A + Q+ V T ++ APE Sbjct: 127 KGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPE 186 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244 V+ QS Y D+WS+G E+ + +P L I Sbjct: 187 VIKQSAYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLI------------------ 228 Query: 245 PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGN 301 P P ++ + + + + L +P R +A L+H ++ + Sbjct: 229 -----PKNSPPTLEG---QHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRYTKK 277 >4CQG-A nrPDB Length = 331 Score = 230 bits (586), Expect = 7e-61, Method: Composition-based stats. Identities = 75/301 (24%), Positives = 116/301 (38%), Gaps = 45/301 (14%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 YE IG G + V A +G VA+K + G + E+ L+ L Sbjct: 11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDLPRVKT----EIDALKSLR- 65 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQF 124 H ++ +L V T K+ +V E+ +L Y+ L E + + RQ Sbjct: 66 --HQHICQLYHVLETKN-----KIFMVLEYCPGGELFDYIISQDR--LSEEETRVVFRQI 116 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR--IYSYQMALTPVVVTLWYRA 182 L + ++H+ HRDLKPEN+L +KL DFGL + L +L Y A Sbjct: 117 LSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDFGLCAKPKGNKDYHLQECCGSLAYAA 176 Query: 183 PEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 PE++ +Y + D+WS+G + + F ++ KI Sbjct: 177 PELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIM-------------- 222 Query: 242 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGN 301 R V + S LL +ML +P KRIS L H ++ +D Sbjct: 223 -------------RGKYEVPKWLSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSC 269 Query: 302 P 302 P Sbjct: 270 P 270 >6FYV-A nrPDB Length = 337 Score = 229 bits (585), Expect = 9e-61, Method: Composition-based stats. Identities = 85/328 (25%), Positives = 136/328 (41%), Gaps = 47/328 (14%) Query: 5 RYEPVAEIGVGAYGTVYKARDPH-SGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 RYE V +G GA+G V + D G VA+K V+ G + E+ +L L Sbjct: 15 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVK------NVGRYREAARSEIQVLEHL 68 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 + + PN V V D V +VFE + ++ + + I+ + Q Sbjct: 69 NSTD-PNSV-FRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQ 126 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTS-------------------GGTVKLADFGLARI 164 + ++FLH N + H DLKPENIL +K+ DFG A Sbjct: 127 ICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATY 186 Query: 165 YSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLG 224 + +V T YRAPEV+L ++ P D+WS+GCI E + +F + + L Sbjct: 187 --DDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLA 244 Query: 225 KIFDLIGLPPEDDWPR--------------DVSLPRGAFPPRGPRPVQSVV---PEMEES 267 + ++G P+ + D G + R +P++ + E E Sbjct: 245 MMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEK 304 Query: 268 GAQLLLEMLTFNPHKRISAFRALQHSYL 295 L+ ML ++P +RI+ ALQH + Sbjct: 305 LFDLVRRMLEYDPTQRITLDEALQHPFF 332 >4D2V-A nrPDB Length = 356 Score = 229 bits (585), Expect = 9e-61, Method: Composition-based stats. Identities = 75/301 (24%), Positives = 118/301 (39%), Gaps = 45/301 (14%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 YE IG G + V A +G VA+K + G + E+ L+ L Sbjct: 31 YELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKT----EIEALKNLR- 85 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQF 124 H ++ +L V T+ K+ +V E+ +L Y+ L E + + RQ Sbjct: 86 --HQHICQLYHVLETAN-----KIFMVLEYCPGGELFDYIISQDR--LSEEETRVVFRQI 136 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR--IYSYQMALTPVVVTLWYRA 182 + + ++H+ HRDLKPEN+L +KL DFGL + L L Y A Sbjct: 137 VSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQACCGALAYAA 196 Query: 183 PEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 PE++ +Y + D+WS+G + + F ++ A + KI Sbjct: 197 PELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIM-------------- 242 Query: 242 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGN 301 R V + S LL +ML +P KRIS L H ++ +D Sbjct: 243 -------------RGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNY 289 Query: 302 P 302 P Sbjct: 290 P 290 >4JDH-A nrPDB Length = 346 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 71/288 (24%), Positives = 122/288 (42%), Gaps = 40/288 (13%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +IG G+ G V A SG VA+K + + EV ++R ++H N Sbjct: 81 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR-----ELLFNEVVIMR---DYQHEN 132 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 VV + + ++ +V E ++ T + + E I + L+ L Sbjct: 133 VVEMYNSYLVGD-----ELWVVMEFLEGGALTDI--VTHTRMNEEQIAAVCLAVLQALSV 185 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPEVLLQS 189 LHA ++HRD+K ++IL+T G VKL+DFG S ++ +V T ++ APE++ + Sbjct: 186 LHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL 245 Query: 190 TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAF 249 Y VD+WS+G + EM +P + + I D + Sbjct: 246 PYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL------------------- 286 Query: 250 PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 P + + V P + L +L +P +R +A L+H +L K Sbjct: 287 -PPRLKNLHKVSPSL----KGFLDRLLVRDPAQRATAAELLKHPFLAK 329 >3RAW-A nrPDB Length = 381 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 83/329 (25%), Positives = 139/329 (42%), Gaps = 47/329 (14%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGH-FVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 RYE V +G G +G V + D G VALK +R G + E+ +L++ Sbjct: 51 ERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIR------NVGKYREAARLEINVLKK 104 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 ++ + N + + V + + + + FE + ++ +L + P ++ + Sbjct: 105 IKEKDKEN--KFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAY 162 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTS-------------------GGTVKLADFGLAR 163 Q L FLH N + H DLKPENIL + ++++ADFG A Sbjct: 163 QLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSAT 222 Query: 164 IYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQL 223 T +V T YR PEV+L+ +A P D+WS+GCI E +R LF + + L Sbjct: 223 F--DHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHL 280 Query: 224 GKIFDLIGLPPEDDWPR--------------DVSLPRGAFPPRGPRPVQSVVPEMEESGA 269 + ++G P R D + G + +P++S + + Sbjct: 281 VMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHV 340 Query: 270 ---QLLLEMLTFNPHKRISAFRALQHSYL 295 L+ ML F+P +RI+ AL H + Sbjct: 341 QLFDLMRRMLEFDPAQRITLAEALLHPFF 369 >4XBR-A nrPDB Length = 366 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 71/288 (24%), Positives = 122/288 (42%), Gaps = 40/288 (13%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +IG G+ G V A SG VA+K + + EV ++R ++H N Sbjct: 101 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR-----ELLFNEVVIMR---DYQHEN 152 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 VV + + ++ +V E ++ T + + E I + L+ L Sbjct: 153 VVEMYNSYLVGD-----ELWVVMEFLEGGALTDI--VTHTRMNEEQIAAVCLAVLQALSV 205 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPEVLLQS 189 LHA ++HRD+K ++IL+T G VKL+DFG S ++ +V T ++ APE++ + Sbjct: 206 LHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL 265 Query: 190 TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAF 249 Y VD+WS+G + EM +P + + I D + Sbjct: 266 PYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL------------------- 306 Query: 250 PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 P + + V P + L +L +P +R +A L+H +L K Sbjct: 307 -PPRLKNLHKVSPSL----KGFLDRLLVRDPAQRATAAELLKHPFLAK 349 >1KOA-A nrPDB Length = 491 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 67/295 (22%), Positives = 116/295 (39%), Gaps = 38/295 (12%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 Y+ E+G GA+G V++ + +G+ A K V P+ + +E+ + L Sbjct: 51 DHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDK-----ETVRKEIQTMSVL 105 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 HP +V L D ++ +++E + + + + MRQ Sbjct: 106 R---HPTLVNLHDAFEDDN-----EMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQ 157 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTS--GGTVKLADFGLARIYSYQMALTPVVVTLWYR 181 +GL +H N VH DLKPENI+ T+ +KL DFGL + ++ T + Sbjct: 158 VCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFA 217 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 APEV DMWSVG + + F G ++ + L + Sbjct: 218 APEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSC------------ 265 Query: 242 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 S + E G + ++L +P+ R++ +AL+H +L Sbjct: 266 -----------DWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLT 309 >2Q0N-A nrPDB Length = 301 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 71/288 (24%), Positives = 122/288 (42%), Gaps = 40/288 (13%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +IG G+ G V A SG VA+K + + EV ++R ++H N Sbjct: 36 KIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRR-----ELLFNEVVIMR---DYQHEN 87 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 VV + + ++ +V E ++ T + + E I + L+ L Sbjct: 88 VVEMYNSYLVGD-----ELWVVMEFLEGGALTDI--VTHTRMNEEQIAAVCLAVLQALSV 140 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRAPEVLLQS 189 LHA ++HRD+K ++IL+T G VKL+DFG S ++ +V T ++ APE++ + Sbjct: 141 LHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRL 200 Query: 190 TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAF 249 Y VD+WS+G + EM +P + + I D + Sbjct: 201 PYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNL------------------- 241 Query: 250 PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 P + + V P + L +L +P +R +A L+H +L K Sbjct: 242 -PPRLKNLHKVSPSL----KGFLDRLLVRDPAQRATAAELLKHPFLAK 284 >4JXF-A nrPDB Length = 266 Score = 229 bits (583), Expect = 1e-60, Method: Composition-based stats. Identities = 68/299 (22%), Positives = 122/299 (40%), Gaps = 38/299 (12%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 ++ +G G++ VY+A H+G VA+K + G+ EV + Sbjct: 5 KIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMI--DKKAMYKAGMVQRVQNEVKIHC 62 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 +L+ HP+++ L + S V LV E K + M Sbjct: 63 QLK---HPSILELYNYFEDSN-----YVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFM 114 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS-YQMALTPVVVTLWY 180 Q + G+ +LH++ I+HRDL N+L+T +K+ADFGLA + T Y Sbjct: 115 HQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNY 174 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 +PE+ +S + D+WS+GC+F + +P F ++ + L K+ + + P Sbjct: 175 ISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLA-----DYEMPS 229 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE 299 +S+ L+ ++L NP R+S L H ++ ++ Sbjct: 230 FLSI----------------------EAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNS 266 >5J5T-A nrPDB Length = 370 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 74/298 (24%), Positives = 121/298 (40%), Gaps = 40/298 (13%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 +E + IG G YG VYKAR+ ++G A+K +++ G +E+ +++ Sbjct: 4 EDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV-----VQQEIIMMKDC 58 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 + HPN+V R K+ + E + P L I + R+ Sbjct: 59 K---HPNIVAYFGSYL-----RRDKLWICMEFCGGGSLQDIYHVTGP-LSELQIAYVSRE 109 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRA 182 L+GL +LH+ +HRD+K NIL+T G VKLADFG++ + + + T ++ A Sbjct: 110 TLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKAFIGTPYWMA 169 Query: 183 PEVL---LQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 PEV + Y D+W+VG E+ +P L + PP Sbjct: 170 PEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPP----- 224 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 + S + LT NP KR +A + LQH ++ + Sbjct: 225 -----------------KLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQ 265 >3UC3-A nrPDB Length = 361 Score = 229 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 73/299 (24%), Positives = 110/299 (36%), Gaps = 39/299 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + RY+ V +IG G +G RD + VA+K + G + + RE+ R Sbjct: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYI------ERGAAIDENVQREIINHRS 72 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L HPN+VR +V T + ++ E+ Y + + + Sbjct: 73 LR---HPNIVRFKEVILTP-----THLAIIMEYASGG-ELYERICNAGRFSEDEARFFFQ 123 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSG--GTVKLADFGLARIYSYQMALTPVVVTLWY 180 Q L G+ + H+ I HRDLK EN L+ +K+ DFG ++ V T Y Sbjct: 124 QLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAY 183 Query: 181 RAPEVLLQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 APEVLL+ Y D+WS G M F E K I L + P Sbjct: 184 IAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRI-LSVKYSIP 242 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 D+ + L+ + +P RIS HS+ K+ Sbjct: 243 DDIRI--------------------SPECCHLISRIFVADPATRISIPEIKTHSWFLKN 281 >5X8I-B nrPDB Length = 346 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 80/330 (24%), Positives = 135/330 (40%), Gaps = 47/330 (14%) Query: 3 TSRYEPVAEIGVGAYGTVYKAR-DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 ++RYE V +G GA+G V + G VA+K V+ + + E+ +L Sbjct: 12 SARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDR------YCEAARSEIQVLE 65 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 L + PN V + + +VFE + ++ + + I+ + Sbjct: 66 HLNTTD-PNS-TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMA 123 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTS-------------------GGTVKLADFGLA 162 Q + ++FLH+N + H DLKPENIL +K+ DFG A Sbjct: 124 YQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSA 183 Query: 163 RIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQ 222 + +V T YRAPEV+L ++ P D+WS+GCI E + +F + + Sbjct: 184 TY--DDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEH 241 Query: 223 LGKIFDLIGLPP--------------EDDWPRDVSLPRGAFPPRGPRPVQSVV---PEME 265 L + ++G P D D G + R +P++ + Sbjct: 242 LAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEH 301 Query: 266 ESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 E L+ +ML ++P KRI+ AL+H + Sbjct: 302 ERLFDLIQKMLEYDPAKRITLREALKHPFF 331 >4FZF-B nrPDB Length = 283 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 67/297 (22%), Positives = 128/297 (43%), Gaps = 41/297 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 + + IG G++G V+K D + VA+K + + + +E+ +L + ++ Sbjct: 10 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQ----QEITVLSQCDS 65 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 V + K+ ++ E++ L +A P I ++++ L Sbjct: 66 S---YVTKYYGSYLKGS-----KLWIIMEYLGGGSALDLLRAGP--FDEFQIATMLKEIL 115 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY-QMALTPVVVTLWYRAPE 184 +GLD+LH+ +HRD+K N+L++ G VKLA FG+A + Q+ V T ++ APE Sbjct: 116 KGLDYLHSEKKIHRDIKAANVLLSEQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPE 175 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244 V+ QS Y + D+WS+G E+ + +P ++ L P+++ P V Sbjct: 176 VIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHP-------MRVLFLIPKNNPPTLVGD 228 Query: 245 PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGN 301 +F + + L +P R +A L+H ++ K+ Sbjct: 229 FTKSF-------------------KEFIDACLNKDPSFRPTAKELLKHKFIVKNSKK 266 >1FOT-A nrPDB Length = 318 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 61/300 (20%), Positives = 113/300 (37%), Gaps = 47/300 (15%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 ++ + +G G++G V+ R H+G + A+K ++ + R L Sbjct: 6 QDFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTNDER-----LML 60 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLMR 122 HP ++R+ ++ ++ ++ ++++ L + L K+ P K Sbjct: 61 SIVTHPFIIRMWGTFQDAQ-----QIFMIMDYIEGGELFSLLRKSQR--FPNPVAKFYAA 113 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 + L++LH+ I++RDLKPENIL+ G +K+ DFG A+ + T Y A Sbjct: 114 EVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYVPD--VTYTLCGTPDYIA 171 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 PEV+ Y +D WS G + EM F ++ KI + Sbjct: 172 PEVVSTKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNA------------- 218 Query: 243 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-----SAFRALQHSYLHK 297 P E LL ++T + +R+ H + + Sbjct: 219 --------------ELRFPPFFNEDVKDLLSRLITRDLSQRLGNLQNGTEDVKNHPWFKE 264 >6HXF-B nrPDB Length = 302 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 74/302 (24%), Positives = 121/302 (40%), Gaps = 43/302 (14%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +E V E+G GA+G VYKA++ +G A K + + + + L Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDY--------IVEIEILAT 72 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 +HP +V+L+ + K+ ++ E + GL I+ + RQ L Sbjct: 73 CDHPYIVKLLGAYYH-----DGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQML 127 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGL-ARIYSYQMALTPVVVTLWYRAPE 184 L+FLH+ I+HRDLK N+L+T G ++LADFG+ A+ + T ++ APE Sbjct: 128 EALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPE 187 Query: 185 VLL-----QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 V++ + Y D+WS+G EM + +P + L KI Sbjct: 188 VVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIA------------ 235 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE 299 + P + L L NP R SA + L+H ++ Sbjct: 236 ------------KSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSIT 283 Query: 300 GN 301 N Sbjct: 284 SN 285 >4B6L-A nrPDB Length = 281 Score = 227 bits (579), Expect = 5e-60, Method: Composition-based stats. Identities = 70/293 (23%), Positives = 113/293 (38%), Gaps = 39/293 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y +G G + Y+A D +G A+K + P + E+ L R L Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVI--PQSRVAKPHQREKILNEIELHRDL-- 66 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 +H ++VR + + + + E + ++ KA L ++ +RQ L Sbjct: 67 -QHRHIVRF-----SHHFEDADNIYIFLELCSRKSLAHIWKARHTLL-EPEVRYYLRQIL 119 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLA-RIYSYQMALTPVVVTLWYRAPE 184 GL +LH I+HRDLK N +T +K+ DFGLA R+ + + T Y APE Sbjct: 120 SGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPE 179 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244 VLL+ + D+WS+GC+ + P F + I + P Sbjct: 180 VLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPA--------- 230 Query: 245 PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 + QLL +L +P R S + L+H + K Sbjct: 231 ------------------SLSLPARQLLAAILRASPRDRPSIDQILRHDFFTK 265 >4L42-A nrPDB Length = 346 Score = 227 bits (578), Expect = 6e-60, Method: Composition-based stats. Identities = 68/302 (22%), Positives = 114/302 (37%), Gaps = 48/302 (15%) Query: 6 YEPVAEIGVGAYGTVYKARDP---HSGHFVALKSVRVPNG-GGGGGGLPISTVREVALLR 61 +E + +G G YG V++ R ++G A+K ++ R + Sbjct: 20 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNI---- 75 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 LE +HP +V L+ T K+ L+ E++ ++ +T + Sbjct: 76 -LEEVKHPFIVDLIYAFQTGG-----KLYLILEYLSGG-ELFMQLEREGIFMEDTACFYL 128 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-YSYQMALTPVVVTLWY 180 + L LH I++RDLKPENI++ G VKL DFGL + T+ Y Sbjct: 129 AEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEY 188 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 APE+L++S + VD WS+G + +M P F G + + KI Sbjct: 189 MAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC----------- 237 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-----SAFRALQHSYL 295 ++ P + + LL ++L N R+ A H + Sbjct: 238 ----------------KLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF 281 Query: 296 HK 297 Sbjct: 282 RH 283 >1KOB-A nrPDB Length = 387 Score = 227 bits (578), Expect = 6e-60, Method: Composition-based stats. Identities = 62/298 (20%), Positives = 114/298 (38%), Gaps = 38/298 (12%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y+ + E+G GA+G V++ + +G K + P + E++++ +L Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDK-----YTVKNEISIMNQL-- 105 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 HP ++ L D ++ L+ E + A + + + MRQ Sbjct: 106 -HHPKLINLHDAFEDKY-----EMVLILEFLSGGELFDRIAAEDYKMSEAEVINYMRQAC 159 Query: 126 RGLDFLHANCIVHRDLKPENILVTSG--GTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183 GL +H + IVH D+KPENI+ + +VK+ DFGLA + + T + AP Sbjct: 160 EGLKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAP 219 Query: 184 EVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 E++ + DMW++G + + F G + + L + Sbjct: 220 EIVDREPVGFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRC-------------- 265 Query: 244 LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGN 301 + + + +L P KR++ AL+H +L D N Sbjct: 266 ---------DWEFDEDAFSSVSPEAKDFIKNLLQKEPRKRLTVHDALEHPWLKGDHSN 314 >3ZUT-A nrPDB Length = 362 Score = 227 bits (578), Expect = 7e-60, Method: Composition-based stats. Identities = 74/299 (24%), Positives = 109/299 (36%), Gaps = 39/299 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + RYE V +IG G +G RD S VA+K + G + + RE+ R Sbjct: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYI------ERGEKIDENVKREIINHRS 71 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L HPN+VR +V T + +V E+ + + + + Sbjct: 72 LR---HPNIVRFKEVILTP-----THLAIVMEYASGG-ELFERICNAGRFSEDEARFFFQ 122 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSG--GTVKLADFGLARIYSYQMALTPVVVTLWY 180 Q + G+ + HA + HRDLK EN L+ +K+ FG ++ V T Y Sbjct: 123 QLISGVSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAY 182 Query: 181 RAPEVLLQSTYATPV-DMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 APEVLL+ Y V D+WS G M F E K I L + P Sbjct: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI-LNVQYAIP 241 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 V + L+ + +P KRIS H + K+ Sbjct: 242 DYVHI--------------------SPECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 >4U41-A nrPDB Length = 332 Score = 227 bits (578), Expect = 7e-60, Method: Composition-based stats. Identities = 71/306 (23%), Positives = 114/306 (37%), Gaps = 41/306 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +E V +G G YG VYK R +G A+K + V L E+ +L+ + Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKL------EINMLK--KY 77 Query: 66 FEHPNVVRLMDVC-ATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQ 123 H N+ S + ++ LV E + + L + I + R+ Sbjct: 78 SHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISRE 137 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRA 182 LRGL LH + ++HRD+K +N+L+T VKL DFG++ + + T ++ A Sbjct: 138 ILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMA 197 Query: 183 PEVLL-----QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 PEV+ +TY D+WS G EM P C + L P + Sbjct: 198 PEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHP-------MRALFLIPRNP 250 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 PR S + L N +R S + L+H ++ Sbjct: 251 PPRLKSKKWSKKFFSF------------------IEGCLVKNYMQRPSTEQLLKHPFIRD 292 Query: 298 DEGNPE 303 + Sbjct: 293 QPNERQ 298 >5KCV-A nrPDB Length = 460 Score = 226 bits (577), Expect = 8e-60, Method: Composition-based stats. Identities = 62/304 (20%), Positives = 110/304 (36%), Gaps = 49/304 (16%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + + +E + +G G +G V ++ +G + A+K ++ T Sbjct: 159 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN----- 213 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKD 119 R L+ HP + L T ++ V E+ + L +L + + + Sbjct: 214 RVLQNSRHPFLTALKYSFQT-----HDRLCFVMEYANGGELFFHLSRER--VFSEDRARF 266 Query: 120 LMRQFLRGLDFLHA-NCIVHRDLKPENILVTSGGTVKLADFGLARI-YSYQMALTPVVVT 177 + + LD+LH+ +V+RDLK EN+++ G +K+ DFGL + + T Sbjct: 267 YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGT 326 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI-FDLIGLPPED 236 Y APEVL + Y VD W +G + EM + F I + I P Sbjct: 327 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR-- 384 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-----SAFRALQ 291 + LL +L +P +R+ A +Q Sbjct: 385 --------------------------TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQ 418 Query: 292 HSYL 295 H + Sbjct: 419 HRFF 422 >3Q53-A nrPDB Length = 306 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 73/294 (24%), Positives = 124/294 (42%), Gaps = 40/294 (13%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 +Y +IG GA GTVY A D +G VA++ + + + E+ ++R Sbjct: 21 KKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMNLQQQPKK-----ELIINEILVMRE- 74 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 ++PN+V +D ++ +V E++ T D + I + R+ Sbjct: 75 --NKNPNIVNYLDSYLVGD-----ELWVVMEYLAGGSLT--DVVTETCMDEGQIAAVCRE 125 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-ALTPVVVTLWYRA 182 L+ L+FLH+N ++HRD+K +NIL+ G+VKL DFG + + + +V T ++ A Sbjct: 126 CLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMA 185 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 PEV+ + Y VD+WS+G + EM +P + + L I Sbjct: 186 PEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIA--------------- 230 Query: 243 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 P ++ L L + KR SA +QH +L Sbjct: 231 ---------TNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELIQHQFLK 275 >6FDY-U nrPDB Length = 276 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 79/296 (26%), Positives = 121/296 (40%), Gaps = 41/296 (13%) Query: 4 SRYEPVAEIGVGAYGTVYKAR-DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + +G G Y TVYKA + VA+K V + + + E+ + Sbjct: 11 DGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASV---ENLLTEIEI--- 64 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLM 121 L+ HP++V+L D S + L+ E DL ++ LP + + M Sbjct: 65 LKGIRHPHIVQLKDFQWDSDN-----IYLIMEFCAGGDLSRFI--HTRRILPEKVARVFM 117 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVT--SGGTVKLADFGLARIYSYQMALTPVVVTLW 179 +Q L FLH I H DLKP+NIL++ +KLADFG A+ S + + Sbjct: 118 QQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPL 177 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 Y APE++ Q Y VD+WS+G I E +P F S ++ KI Sbjct: 178 YMAPEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSN---------- 227 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 R + LP + P + LL +L +P +RIS H ++ Sbjct: 228 RVIELP--------------LRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWV 269 >2JDO-A nrPDB Length = 342 Score = 225 bits (575), Expect = 1e-59, Method: Composition-based stats. Identities = 62/303 (20%), Positives = 111/303 (36%), Gaps = 48/303 (15%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + + ++ + +G G +G V R+ +G + A+K +R V Sbjct: 7 VTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHT-----VTES 61 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKD 119 R L+ HP + L T ++ V E+ + L +L + E + Sbjct: 62 RVLQNTRHPFLTALKYAFQT-----HDRLCFVMEYANGGELFFHLSRER--VFTEERARF 114 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-YSYQMALTPVVVTL 178 + + L++LH+ +V+RD+K EN+++ G +K+ DFGL + S + T Sbjct: 115 YGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTP 174 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI-FDLIGLPPEDD 237 Y APEVL + Y VD W +G + EM + F I + I P Sbjct: 175 EYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPR--- 231 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-----SAFRALQH 292 + LL +L +P +R+ A ++H Sbjct: 232 -------------------------TLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEH 266 Query: 293 SYL 295 + Sbjct: 267 RFF 269 >4I6B-A nrPDB Length = 308 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 63/295 (21%), Positives = 110/295 (37%), Gaps = 39/295 (13%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 RY +G G + Y+ D + A K + P+ +E+ L R L Sbjct: 28 KRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKII--PHSRVSKPHQREKIDKEIELHRIL 85 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 H +VV+ + ++ E+ + ++ KA L ++ +RQ Sbjct: 86 ---HHKHVVQFYHYFEDKEN-----IYILLEYCSRRSMAHILKARKV-LTEPEVRYYLRQ 136 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLA-RIYSYQMALTPVVVTLWYRA 182 + GL +LH I+HRDLK N + +K+ DFGLA R+ + + T Y + Sbjct: 137 IVSGLKYLHEQEILHRDLKLGNFFINESMELKVGDFGLAARLEPLEHRRRTICGTPNYLS 196 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 PEVL + + D+W++GC+ M +P F + + I + P Sbjct: 197 PEVLNKQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPS------- 249 Query: 243 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 + L+ ML+ NP R S ++H + + Sbjct: 250 --------------------SLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFTQ 284 >3TXO-A nrPDB Length = 353 Score = 225 bits (573), Expect = 2e-59, Method: Composition-based stats. Identities = 70/307 (22%), Positives = 116/307 (37%), Gaps = 46/307 (14%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + +E + +G G++G V AR +G A+K ++ T + + L Sbjct: 20 LGIDNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSL 79 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKD 119 R HP + +L T ++ V E V DL ++ K+ + Sbjct: 80 AR----NHPFLTQLFCCFQTPD-----RLFFVMEFVNGGDLMFHIQKSRR--FDEARARF 128 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALT-PVVVTL 178 + + L FLH I++RDLK +N+L+ G KLADFG+ + T T Sbjct: 129 YAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTP 188 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y APE+L + Y VD W++G + EM F +E D I + E + Sbjct: 189 DYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILN-----DEVVY 243 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-SAFR-----ALQH 292 P + E +L +T NP R+ S + L+H Sbjct: 244 PT----------------------WLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRH 281 Query: 293 SYLHKDE 299 + + + Sbjct: 282 PFFKEID 288 >4RLP-A nrPDB Length = 288 Score = 225 bits (573), Expect = 2e-59, Method: Composition-based stats. Identities = 68/302 (22%), Positives = 114/302 (37%), Gaps = 48/302 (15%) Query: 6 YEPVAEIGVGAYGTVYKARDP---HSGHFVALKSVRVPNG-GGGGGGLPISTVREVALLR 61 +E + +G G YG V++ R ++G A+K ++ R + Sbjct: 7 FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNI---- 62 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 LE +HP +V L+ T K+ L+ E++ ++ +T + Sbjct: 63 -LEEVKHPFIVDLIYAFQTGG-----KLYLILEYLSGG-ELFMQLEREGIFMEDTACFYL 115 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-YSYQMALTPVVVTLWY 180 + L LH I++RDLKPENI++ G VKL DFGL + T+ Y Sbjct: 116 AEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEY 175 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 APE+L++S + VD WS+G + +M P F G + + KI Sbjct: 176 MAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKC----------- 224 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-----SAFRALQHSYL 295 ++ P + + LL ++L N R+ A H + Sbjct: 225 ----------------KLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFF 268 Query: 296 HK 297 Sbjct: 269 RH 270 >3MV5-A nrPDB Length = 342 Score = 225 bits (573), Expect = 2e-59, Method: Composition-based stats. Identities = 62/304 (20%), Positives = 110/304 (36%), Gaps = 49/304 (16%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + + +E + +G G +G V ++ +G + A+K ++ T Sbjct: 7 VTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTEN----- 61 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKD 119 R L+ HP + L T ++ V E+ + L +L + + + Sbjct: 62 RVLQNSRHPFLTALKYSFQT-----HDRLCFVMEYANGGELFFHLSRER--VFSEDRARF 114 Query: 120 LMRQFLRGLDFLHA-NCIVHRDLKPENILVTSGGTVKLADFGLARI-YSYQMALTPVVVT 177 + + LD+LH+ +V+RDLK EN+++ G +K+ DFGL + + T Sbjct: 115 YGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGT 174 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI-FDLIGLPPED 236 Y APEVL + Y VD W +G + EM + F I + I P Sbjct: 175 PEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPR-- 232 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-----SAFRALQ 291 + LL +L +P +R+ A +Q Sbjct: 233 --------------------------TLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQ 266 Query: 292 HSYL 295 H + Sbjct: 267 HRFF 270 >3UDB-A nrPDB Length = 317 Score = 225 bits (573), Expect = 3e-59, Method: Composition-based stats. Identities = 75/299 (25%), Positives = 111/299 (37%), Gaps = 39/299 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + RYE V +IG G +G RD + VA+K + G + + RE+ R Sbjct: 18 SDRYELVKDIGAGNFGVARLMRDKQANELVAVKYI------ERGEKIDENVKREIINHRS 71 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L HPN+VR +V T + +V E+ + + + + Sbjct: 72 LR---HPNIVRFKEVILTP-----THLAIVMEYASGG-ELFERICNAGRFSEDEARFFFQ 122 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGG--TVKLADFGLARIYSYQMALTPVVVTLWY 180 Q + G+ + HA + HRDLK EN L+ +K+ADFG ++ V T Y Sbjct: 123 QLISGVSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAY 182 Query: 181 RAPEVLLQSTYATPV-DMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 APEVLL+ Y V D+WS G M F E K I L + P Sbjct: 183 IAPEVLLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRI-LNVQYAIP 241 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 V + L+ + +P KRIS H + K+ Sbjct: 242 DYVHI--------------------SPECRHLISRIFVADPAKRISIPEIRNHEWFLKN 280 >5UNP-A nrPDB Length = 369 Score = 224 bits (570), Expect = 5e-59, Method: Composition-based stats. Identities = 79/337 (23%), Positives = 135/337 (40%), Gaps = 49/337 (14%) Query: 4 SRYEPVAEIGVGAYGTVYKAR-DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 RYE V+ +G G +G V + G VALK ++ L I+ + ++ Sbjct: 34 ERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINE--- 90 Query: 63 LEAFEHPNV-VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 + ++ N+ V++ D D + + FE + +L P ++ + Sbjct: 91 -KDPDNKNLCVQMFDWF-----DYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMA 144 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGT-------------------VKLADFGLA 162 Q + + FLH N + H DLKPENIL + V++ DFG A Sbjct: 145 FQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSA 204 Query: 163 RIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQ 222 + +V T YRAPEV+L+ ++ P D+WS+GCI E + LF + + Sbjct: 205 TF--DHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREH 262 Query: 223 LGKIFDLIGLPPEDDWPR--------------DVSLPRGAFPPRGPRPVQSVVPEMEESG 268 L + ++G P + D + G + +P++ + E Sbjct: 263 LAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEH 322 Query: 269 A---QLLLEMLTFNPHKRISAFRALQHSYLHKDEGNP 302 L+ ML + P KR++ ALQH + + P Sbjct: 323 HQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEP 359 >6O6Q-A nrPDB Length = 335 Score = 223 bits (569), Expect = 8e-59, Method: Composition-based stats. Identities = 75/304 (24%), Positives = 137/304 (45%), Gaps = 29/304 (9%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 YE + ++G G Y V+ D V +K ++ RE+++L+ L Sbjct: 41 ENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVK--------RKKIKREISILKNL 92 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 + PN++ ++DV ++ L+FEH++ L P I+ M + Sbjct: 93 --VDGPNIIAMLDVVREPQSKTPG---LIFEHINNIDFRSL----YPTFTDYDIRFYMYE 143 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGT-VKLADFGLARIYSYQMALTPVVVTLWYRA 182 L+ LD+ H+ I+HRD+KP N+++ ++L D+GLA Y V + +++ Sbjct: 144 LLKALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKG 203 Query: 183 PEVL-LQSTYATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 PE+L Y +DMWS GC+ A M F ++P F G S DQL +I ++G + Sbjct: 204 PELLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLE 263 Query: 241 DVSLPRGAFPPR----GPRPVQSVVPE-----MEESGAQLLLEMLTFNPHKRISAFRALQ 291 ++ G R + E + + L+ +L ++ +R++A A++ Sbjct: 264 KYNISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMK 323 Query: 292 HSYL 295 H+Y Sbjct: 324 HAYF 327 >4APC-A nrPDB Length = 350 Score = 223 bits (568), Expect = 8e-59, Method: Composition-based stats. Identities = 65/270 (24%), Positives = 116/270 (42%), Gaps = 13/270 (4%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 + +Y + +IG G++G + G +K + + + REVA+L Sbjct: 22 SMEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKE---REESRREVAVLA 78 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDL 120 ++ HPN+V+ + + + + +V ++ + DL ++ + I D Sbjct: 79 NMK---HPNIVQYRESFEENGS-----LYIVMDYCEGGDLFKRINAQKGVLFQEDQILDW 130 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVV-VTLW 179 Q L +H I+HRD+K +NI +T GTV+L DFG+AR+ + + L T + Sbjct: 131 FVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARACIGTPY 190 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 Y +PE+ Y D+W++GC+ E+ K F S + + KI P + Sbjct: 191 YLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYS 250 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGA 269 D+ R PR SV +E+ Sbjct: 251 YDLRSLVSQLFKRNPRDRPSVNSILEKGFI 280 >5D9K-A nrPDB Length = 330 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 71/303 (23%), Positives = 118/303 (38%), Gaps = 52/303 (17%) Query: 4 SRYEPVAEIGVGAYGTVYKARDP---HSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 S++E + +G G++G V+ + + A+K ++ + R++ Sbjct: 30 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRD-RVRTKMERDI--- 85 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKD 119 L HP +V+L T E K+ L+ + + DL T L K E +K Sbjct: 86 --LVEVNHPFIVKLHYAFQT-----EGKLYLILDFLRGGDLFTRLSKE--VMFTEEDVKF 136 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-YSYQMALTPVVVTL 178 + + LD LH+ I++RDLKPENIL+ G +KL DFGL++ ++ T+ Sbjct: 137 YLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTV 196 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD-LIGLPPEDD 237 Y APEV+ + + D WS G + EM F G + + I +G+P Sbjct: 197 EYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQ--- 253 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISA-----FRALQH 292 + LL + NP R+ A +H Sbjct: 254 -------------------------FLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRH 288 Query: 293 SYL 295 S+ Sbjct: 289 SFF 291 >3HDN-A nrPDB Length = 373 Score = 222 bits (566), Expect = 2e-58, Method: Composition-based stats. Identities = 73/298 (24%), Positives = 116/298 (38%), Gaps = 44/298 (14%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 S + + IG G++G V AR F A+K ++ I + R V L Sbjct: 38 SDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNV----LL 93 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLMR 122 + +HP +V L T+ K+ V ++++ L +L + + Sbjct: 94 KNVKHPFLVGLHFSFQTAD-----KLYFVLDYINGGELFYHLQRERC--FLEPRARFYAA 146 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-YSYQMALTPVVVTLWYR 181 + L +LH+ IV+RDLKPENIL+ S G + L DFGL + + + T Y Sbjct: 147 EIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYL 206 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 APEVL + Y VD W +G + EM P F + A+ I + Sbjct: 207 APEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILN------------- 253 Query: 242 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAF----RALQHSYL 295 +P+ + P + S LL +L + KR+ A H + Sbjct: 254 -------------KPL-QLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFF 297 >2Z7Q-A nrPDB Length = 321 Score = 221 bits (563), Expect = 3e-58, Method: Composition-based stats. Identities = 75/268 (27%), Positives = 114/268 (42%), Gaps = 18/268 (6%) Query: 4 SRYEPVAEIGVGAYGTVYKARDP---HSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 S +E + +G G++G V+ R SGH A+K ++ + R++ Sbjct: 28 SHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATLKVRD-RVRTKMERDI--- 83 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKD 119 L HP VV+L T E K+ L+ + + DL T L K E +K Sbjct: 84 --LADVNHPFVVKLHYAFQT-----EGKLYLILDFLRGGDLFTRLSKE--VMFTEEDVKF 134 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-YSYQMALTPVVVTL 178 + + GLD LH+ I++RDLKPENIL+ G +KL DFGL++ ++ T+ Sbjct: 135 YLAELALGLDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKEAIDHEKKAYSFCGTV 194 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y APEV+ + ++ D WS G + EM F G + + I P+ Sbjct: 195 EYMAPEVVNRQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLS 254 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEE 266 SL R F + S EE Sbjct: 255 TEAQSLLRALFKRNPANRLGSGPDGAEE 282 >2HW6-A nrPDB Length = 307 Score = 220 bits (562), Expect = 4e-58, Method: Composition-based stats. Identities = 75/311 (24%), Positives = 120/311 (38%), Gaps = 41/311 (13%) Query: 10 AEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHP 69 +G GAY V A +G A+K + G REV L + + + Sbjct: 19 ELLGEGAYAKVQGAVSLQNGKEYAVKII-----EKQAGHSRSRVFREVETLYQCQGNK-- 71 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 N++ L++ + + LVFE + + ++ K ++R L Sbjct: 72 NILELIEFFED-----DTRFYLVFEKLQGGSILAHIQKQKH--FNEREASRVVRDVAAAL 124 Query: 129 DFLHANCIVHRDLKPENILVTSG---GTVKLADFGLARIYSYQMALTPV--------VVT 177 DFLH I HRDLKPENIL S VK+ DF L + TP+ + Sbjct: 125 DFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGS 184 Query: 178 LWYRAPEVL-----LQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGL 232 Y APEV+ + Y D+WS+G + M P F G+ AD G + Sbjct: 185 AEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGAD-CGWDRGEVCR 243 Query: 233 PPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQH 292 ++ + + FP + + L+ ++L + +R+SA + LQH Sbjct: 244 VCQNKLFESIQEGKYEFPDKDWAH-------ISSEAKDLISKLLVRDAKQRLSAAQVLQH 296 Query: 293 SYLHKDEGNPE 303 ++ PE Sbjct: 297 PWVQGQA--PE 305 >5F9E-A nrPDB Length = 353 Score = 220 bits (562), Expect = 4e-58, Method: Composition-based stats. Identities = 72/300 (24%), Positives = 113/300 (37%), Gaps = 41/300 (13%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + +E +G G++G V+ A + F A+K+++ + V L Sbjct: 16 LKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSL 75 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKD 119 A+EHP + + T + V E++ DL ++ Sbjct: 76 ----AWEHPFLTHMFCTFQTKEN-----LFFVMEYLNGGDLMYHIQSCHK--FDLSRATF 124 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTP-VVVTL 178 + + GL FLH+ IV+RDLK +NIL+ G +K+ADFG+ + A T T Sbjct: 125 YAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNEFCGTP 184 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y APE+LL Y VD WS G + EM + F G E + I Sbjct: 185 DYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIR----------- 233 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAF-RALQHSYLHK 297 F PR +E+ LL+++ P KR+ QH + Sbjct: 234 ------MDNPFYPRW----------LEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFRE 277 >6CMJ-A nrPDB Length = 321 Score = 220 bits (562), Expect = 4e-58, Method: Composition-based stats. Identities = 75/312 (24%), Positives = 131/312 (41%), Gaps = 43/312 (13%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLP------ISTV 54 + +Y EIG G+YG V A + + + A+K + GG Sbjct: 31 VQLDQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVY 90 Query: 55 REVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPA 114 +E+A+L++L +HPNVV+L++V D + +VFE V+Q ++ L Sbjct: 91 QEIAILKKL---DHPNVVKLVEVLDDPNED---HLYMVFELVNQG--PVMEVPTLKPLSE 142 Query: 115 ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-LTP 173 + + + ++G+++LH I+HRD+KP N+LV G +K+ADFG++ + A L+ Sbjct: 143 DQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSN 202 Query: 174 VVVTLWYRAPEVLLQST---YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLI 230 V T + APE L ++ +D+W++G + F +I Sbjct: 203 TVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF-------MDERIM--- 252 Query: 231 GLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRAL 290 + FP + P++ E L+ ML NP RI Sbjct: 253 ------CLHSKIKSQALEFPDQ---------PDIAEDLKDLITRMLDKNPESRIVVPEIK 297 Query: 291 QHSYLHKDEGNP 302 H ++ + P Sbjct: 298 LHPWVTRHGAEP 309 >6C9D-A nrPDB Length = 459 Score = 220 bits (560), Expect = 8e-58, Method: Composition-based stats. Identities = 61/234 (26%), Positives = 97/234 (41%), Gaps = 15/234 (6%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 Y IG G + V AR +G VA+K + REV +++ Sbjct: 20 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQ---KLFREVRIMKI 76 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLM 121 L HPN+V+L +V T +T + LV E+ + YL + + + Sbjct: 77 L---NHPNIVKLFEVIETEKT-----LYLVMEYASGGEVFDYL--VAHGRMKEKEARAKF 126 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYR 181 RQ + + + H IVHRDLK EN+L+ +K+ADFG + ++ L + Y Sbjct: 127 RQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDEFCGSPPYA 186 Query: 182 APEVLLQSTYA-TPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 APE+ Y VD+WS+G I + F G + + ++ P Sbjct: 187 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP 240 >2HAK-A nrPDB Length = 328 Score = 219 bits (559), Expect = 9e-58, Method: Composition-based stats. Identities = 61/234 (26%), Positives = 97/234 (41%), Gaps = 15/234 (6%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 Y IG G + V AR +G VA+K + REV +++ Sbjct: 14 IGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQ---KLFREVRIMKI 70 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLM 121 L HPN+V+L +V T +T + LV E+ + YL + + + Sbjct: 71 L---NHPNIVKLFEVIETEKT-----LYLVMEYASGGEVFDYL--VAHGRMKEKEARAKF 120 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYR 181 RQ + + + H IVHRDLK EN+L+ +K+ADFG + ++ L + Y Sbjct: 121 RQIVSAVQYCHQKYIVHRDLKAENLLLDGDMNIKIADFGFSNEFTVGNKLDTFCGSPPYA 180 Query: 182 APEVLLQSTYA-TPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 APE+ Y VD+WS+G I + F G + + ++ P Sbjct: 181 APELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIP 234 >3DAK-A nrPDB Length = 290 Score = 219 bits (559), Expect = 1e-57, Method: Composition-based stats. Identities = 69/308 (22%), Positives = 118/308 (38%), Gaps = 43/308 (13%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 YE IG GA V A VA+K + + ++E+ + + Sbjct: 10 DDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMD----ELLKEIQAMSQC 65 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKA-------PPPGLPAET 116 HPN+V + ++ LV + + + K L T Sbjct: 66 ---HHPNIVSYYTSFVV-----KDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDEST 117 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALT---- 172 I ++R+ L GL++LH N +HRD+K NIL+ G+V++ADFG++ + +T Sbjct: 118 IATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKV 177 Query: 173 --PVVVTLWYRAPEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDL 229 V T + APEV+ Q Y D+WS G E+ + L + L Sbjct: 178 RKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVL--MLTL 235 Query: 230 IGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 PP + + ++ + +S +++ L +P KR +A Sbjct: 236 QNDPPSLE---------------TGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAEL 280 Query: 290 LQHSYLHK 297 L+H + K Sbjct: 281 LRHKFFQK 288 >4B8L-A nrPDB Length = 286 Score = 218 bits (556), Expect = 2e-57, Method: Composition-based stats. Identities = 61/298 (20%), Positives = 120/298 (40%), Gaps = 41/298 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 ++ +G G +G VY AR+ + +ALK + G+ RE+ + Sbjct: 14 IDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVL--FKSQLEKEGVEHQLRREIEIQSH 71 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLM 121 L HPN++R+ + + ++ L+ E +L L K + M Sbjct: 72 LR---HPNILRMYNYFHDRK-----RIYLMLEFAPRGELYKELQKHGR--FDEQRSATFM 121 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYR 181 + L + H ++HRD+KPEN+L+ G +K+ADFG + +++ + + TL Y Sbjct: 122 EELADALHYCHERKVIHRDIKPENLLMGYKGELKIADFGWS-VHAPSLRRRTMCGTLDYL 180 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 PE++ T+ VD+W G + E P F S + +I ++ Sbjct: 181 PPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNV------------ 228 Query: 242 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE 299 P + + L+ ++L ++P +R+ ++H ++ + Sbjct: 229 ---------------DLKFPPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVKANS 271 >3LM0-A nrPDB Length = 327 Score = 217 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 69/292 (23%), Positives = 120/292 (41%), Gaps = 37/292 (12%) Query: 10 AEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHP 69 E+G G + V + +G A K ++ G + E+A+L ++ P Sbjct: 35 KELGRGKFAVVRQCISKSTGQEYAAKFLKK---RRRGQDCRAEILHEIAVLELAKS--CP 89 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 V+ L +V + ++ L+ E+ ++ + + + L++Q L G+ Sbjct: 90 RVINLHEVYENTS-----EIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGV 144 Query: 129 DFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 +LH N IVH DLKP+NIL++S G +K+ DFG++R + L ++ T Y APE+ Sbjct: 145 YYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEI 204 Query: 186 LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP 245 L T DMW++G I + F G + I + +V Sbjct: 205 LNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQV-----------NVDYS 253 Query: 246 RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 F + + + +L NP KR +A L HS+L + Sbjct: 254 EETF------------SSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQ 293 >5XVU-A nrPDB Length = 332 Score = 217 bits (553), Expect = 5e-57, Method: Composition-based stats. Identities = 79/307 (25%), Positives = 138/307 (44%), Gaps = 30/307 (9%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 +RYE + +IG G Y V+ D A RE+ +L+ L Sbjct: 31 NRYEIMKKIGRGKYSEVFNGYDTECNRPCA--------IKVLKPVKKKKIKREIKILQNL 82 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 PN+++L+D+ T L+FE+++ L P + I+ + Q Sbjct: 83 NGG--PNIIKLLDIVKDPVTKTPS---LIFEYINNIDFKTL----YPKFTDKDIRYYIYQ 133 Query: 124 FLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 L+ LD+ H+ I+HRD+KP NI++ ++L +GLA Y V + +Y+ Sbjct: 134 ILKALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRVASRYYKG 193 Query: 183 PEVLLQ-STYATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 PE+L+ Y +D+WS+GC+ A M F+++P FCG+ DQL KI ++G + + Sbjct: 194 PELLIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLK 253 Query: 241 DVSLP----------RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRAL 290 ++ P QS + ++ L+ +ML ++ KRI+ A+ Sbjct: 254 KYNIKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAM 313 Query: 291 QHSYLHK 297 +H Y + Sbjct: 314 EHPYFRE 320 >3DB8-A nrPDB Length = 317 Score = 217 bits (553), Expect = 5e-57, Method: Composition-based stats. Identities = 68/295 (23%), Positives = 107/295 (36%), Gaps = 39/295 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 RY +G G + Y+ D + A K V P E+A+ + Sbjct: 41 MKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVV--PKSMLLKPHQKEKMSTEIAIHKS 98 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L ++P+VV V +V E + L K + + MR Sbjct: 99 L---DNPHVVGFHGFFEDDDF-----VYVVLEICRRRSLLELHKRRK-AVTEPEARYFMR 149 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS-YQMALTPVVVTLWYR 181 Q ++G+ +LH N ++HRDLK N+ + VK+ DFGLA + T Y Sbjct: 150 QTIQGVQYLHNNRVIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKDLCGTPNYI 209 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 APEVL + ++ VD+WS+GCI + KP F + + +I Sbjct: 210 APEVLCKKGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRI--------------- 254 Query: 242 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 + SV + + L+ ML +P R S L + Sbjct: 255 ------------KKNEYSVPRHINPVASALIRRMLHADPTLRPSVAELLTDEFFT 297 >5N23-A nrPDB Length = 352 Score = 217 bits (553), Expect = 5e-57, Method: Composition-based stats. Identities = 58/298 (19%), Positives = 106/298 (35%), Gaps = 46/298 (15%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 ++E + +G G++G V + +G+ A+K + + + Sbjct: 42 DQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQ----- 96 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMR 122 +A P +V+L + +V E+ ++ ++L + + Sbjct: 97 QAVNFPFLVKL-----EFSFKDNSNLYMVLEYAPGGEMFSHLRRIGR--FSEPHARFYAA 149 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 Q + ++LH+ +++RDLKPEN+L+ G +K+ADFG A+ + T + T Y A Sbjct: 150 QIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTPWT-LCGTPEYLA 208 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 PE++L Y VD W++G + EM P F + KI P Sbjct: 209 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH------ 262 Query: 243 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-----SAFRALQHSYL 295 LL +L + KR H + Sbjct: 263 ---------------------FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 299 >4CRL-A nrPDB Length = 406 Score = 216 bits (551), Expect = 8e-57, Method: Composition-based stats. Identities = 112/326 (34%), Positives = 166/326 (50%), Gaps = 51/326 (15%) Query: 11 EIGVGAYGTVYKARDPHSGHF--VALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 ++G G YG VYKA+ ALK + G G+ +S RE+ALLR L+ H Sbjct: 29 KVGRGTYGHVYKAKRKDGKDDKDYALKQI-------EGTGISMSACREIALLRELK---H 78 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLD-------KAPPPGLPAETIKDLM 121 PNV+ L V + + KV L+F++ + DL + P LP +K L+ Sbjct: 79 PNVISLQKVFLS---HADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLL 135 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVT----SGGTVKLADFGLARIYSYQMA----LTP 173 Q L G+ +LHAN ++HRDLKP NILV G VK+AD G AR+++ + L P Sbjct: 136 YQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDP 195 Query: 174 VVVTLWYRAPEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEA---------DQL 223 VVVT WYRAPE+LL Y +D+W++GCIFAE+ +P+F E DQL Sbjct: 196 VVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQL 255 Query: 224 GKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPV-----------QSVVPEMEESGAQLL 272 +IF+++G P + DW +P + + R + + + LL Sbjct: 256 DRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLL 315 Query: 273 LEMLTFNPHKRISAFRALQHSYLHKD 298 ++LT +P KRI++ +A+Q Y +D Sbjct: 316 QKLLTMDPIKRITSEQAMQDPYFLED 341 >4MD7-E nrPDB Length = 391 Score = 216 bits (551), Expect = 8e-57, Method: Composition-based stats. Identities = 79/305 (25%), Positives = 132/305 (43%), Gaps = 30/305 (9%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 Y+ V ++G G Y V++A + + RE+ +L L Sbjct: 37 DDYQLVRKLGRGKYSEVFEAINITNNEK--------VVVKILKPVKKKKIKREIKILENL 88 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 PN++ L D+ + LVFEHV+ L + L I+ M + Sbjct: 89 RGG--PNIITLADIVKDPVSRTPA---LVFEHVNNTDFKQLYQ----TLTDYDIRFYMYE 139 Query: 124 FLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 L+ LD+ H+ I+HRD+KP N+++ ++L D+GLA Y V + +++ Sbjct: 140 ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG 199 Query: 183 PEVL-LQSTYATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGLPPEDDW-- 238 PE+L Y +DMWS+GC+ A M FR++P F G+ DQL +I ++G D+ Sbjct: 200 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 259 Query: 239 -------PRDVSLPRGAFPPRGPRPVQSVVPEM-EESGAQLLLEMLTFNPHKRISAFRAL 290 PR + R R V S + L ++L ++ R++A A+ Sbjct: 260 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 319 Query: 291 QHSYL 295 +H Y Sbjct: 320 EHPYF 324 >5X3F-B nrPDB Length = 393 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 59/298 (19%), Positives = 107/298 (35%), Gaps = 47/298 (15%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 +++ + +G G++G V + SG+ A+K + T+ E + L Sbjct: 84 DQFDRIKTLGTGSFGRVMLVKHKESGNHYAMKILDKQKVVKLKQI--EHTLNEKRI---L 138 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMR 122 +A P +V+L + +V E+V ++ ++L + + Sbjct: 139 QAVNFPFLVKL-----EFSFKDNSNLYMVMEYVAGGEMFSHLRRIGR--FSEPHARFYAA 191 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 Q + ++LH+ +++RDLKPEN+L+ G +++ DFG A+ + T Y A Sbjct: 192 QIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLA 249 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 PE++L Y VD W++G + EM P F + KI P Sbjct: 250 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH------ 303 Query: 243 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-----SAFRALQHSYL 295 LL +L + KR H + Sbjct: 304 ---------------------FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 340 >3HKO-A nrPDB Length = 345 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 75/342 (21%), Positives = 120/342 (35%), Gaps = 79/342 (23%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 +Y IG G+YG V A + + A+K + EV L+++L Sbjct: 26 KKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINPKDVERIKTEVRLMKKL 85 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-----LRTYLDKAPPPG------- 111 HPN+ RL +V E + LV E L ++D + Sbjct: 86 ---HHPNIARLYEVYED-----EQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKT 137 Query: 112 ---------------------------LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPE 144 + I ++MRQ L +LH I HRD+KPE Sbjct: 138 QICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPE 197 Query: 145 NILVTSGG--TVKLADFGLARIY-----SYQMALTPVVVTLWYRAPEVLL--QSTYATPV 195 N L ++ +KL DFGL++ + +T T ++ APEVL +Y Sbjct: 198 NFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKC 257 Query: 196 DMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR 255 D WS G + + F G ++AD + ++ + + Sbjct: 258 DAWSAGVLLHLLLMGAVPFPGVNDADTISQVLN-----------------------KKLC 294 Query: 256 PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 + LL +L N +R A RALQH ++ + Sbjct: 295 FENPNYNVLSPLARDLLSNLLNRNVDERFDAMRALQHPWISQ 336 >4WNO-A nrPDB Length = 287 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 77/302 (25%), Positives = 120/302 (39%), Gaps = 49/302 (16%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGH-FVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 + IG GA+ V+K R + VA+K + N L +E+ +L+ L Sbjct: 19 EFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLG----KEIKILKEL 74 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMR 122 + H N+V L D + + V LV E+ DL YL L +TI+ ++ Sbjct: 75 K---HENIVALYDFQEMANS-----VYLVMEYCNGGDLADYLHAMR--TLSEDTIRLFLQ 124 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGG---------TVKLADFGLARIYSYQMALTP 173 Q + LH+ I+HRDLKP+NIL+++ VK+ADFG AR M Sbjct: 125 QIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAAT 184 Query: 174 VVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 233 + + Y APEV++ Y D+WS+G I + K F +S D + L Sbjct: 185 LCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQD--------LRLF 236 Query: 234 PEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHS 293 E + ++PR P + + N R+ H Sbjct: 237 YEKNKTLVPTIPRETSAPLRQLLLALLQ----------------RNHKDRMDFDEFFHHP 280 Query: 294 YL 295 +L Sbjct: 281 FL 282 >2OU7-A nrPDB Length = 335 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 66/286 (23%), Positives = 104/286 (36%), Gaps = 39/286 (13%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G G + ++ D + A K V P E+++ R L H +V Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIV--PKSLLLKPHQREKMSMEISIHRSLA---HQHV 103 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFL 131 V + V +V E + L K L + +RQ + G +L Sbjct: 104 VGFHGFFEDNDF-----VFVVLELCRRRSLLELHKRRK-ALTEPEARYYLRQIVLGCQYL 157 Query: 132 HANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPV-VVTLWYRAPEVLLQST 190 H N ++HRDLK N+ + VK+ DFGLA Y V T Y APEVL + Sbjct: 158 HRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKG 217 Query: 191 YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFP 250 ++ VD+WS+GCI + KP F + + +I Sbjct: 218 HSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRI------------------------ 253 Query: 251 PRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 + S+ + A L+ +ML +P R + L + Sbjct: 254 ---KKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFT 296 >4AF3-A nrPDB Length = 292 Score = 215 bits (547), Expect = 2e-56, Method: Composition-based stats. Identities = 69/298 (23%), Positives = 123/298 (41%), Gaps = 41/298 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 +E +G G +G VY AR+ S VALK + G+ RE+ + Sbjct: 22 IDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVL--FKSQIEKEGVEHQLRREIEIQAH 79 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLM 121 L HPN++RL + R ++ L+ E+ +L L K+ + +M Sbjct: 80 L---HHPNILRLYNYFYDRR-----RIYLILEYAPRGELYKELQKS--CTFDEQRTATIM 129 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYR 181 + L + H ++HRD+KPEN+L+ G +K+ADFG + +++ + + TL Y Sbjct: 130 EELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWS-VHAPSLRRKTMCGTLDYL 188 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 PE++ + VD+W +G + E+ P F S + +I + D Sbjct: 189 PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKV-------DLKFP 241 Query: 242 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE 299 S+P G L+ ++L NP +R+ + H ++ + Sbjct: 242 ASVPTG--------------------AQDLISKLLRHNPSERLPLAQVSAHPWVRANS 279 >1VZO-A nrPDB Length = 355 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 70/310 (22%), Positives = 122/310 (39%), Gaps = 46/310 (14%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARD---PHSGHFVALKSVRVPNGGGGGGGLPISTVREV 57 + +E + +G GAYG V+ R +G A+K ++ T E Sbjct: 51 VGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQ-KAKTTEHTRTER 109 Query: 58 ALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAET 116 +L + P +V L T E K+ L+ ++++ L T+L + Sbjct: 110 QVLEHIRQS--PFLVTLHYAFQT-----ETKLHLILDYINGGELFTHLSQRER--FTEHE 160 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY--SYQMALTPV 174 ++ + + + L+ LH I++RD+K ENIL+ S G V L DFGL++ + Sbjct: 161 VQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYDF 220 Query: 175 VVTLWYRAPEVLLQS--TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGL 232 T+ Y AP+++ + VD WS+G + E+ F + E + +I I L Sbjct: 221 CGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRI-L 279 Query: 233 PPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-----SAF 287 E +P+ EM L+ +L +P KR+ A Sbjct: 280 KSEPPYPQ----------------------EMSALAKDLIQRLLMKDPKKRLGCGPRDAD 317 Query: 288 RALQHSYLHK 297 +H + K Sbjct: 318 EIKEHLFFQK 327 >3KN6-A nrPDB Length = 325 Score = 214 bits (545), Expect = 4e-56, Method: Composition-based stats. Identities = 69/301 (22%), Positives = 119/301 (39%), Gaps = 41/301 (13%) Query: 10 AEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHP 69 +G G++ K S A+K + + +T +E+ L+ E HP Sbjct: 17 KPLGEGSFSICRKCVHKKSNQAFAVKIISK--------RMEANTQKEITALKLCEG--HP 66 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 N+V+L +V ++ LV E ++ L + K +MR+ + + Sbjct: 67 NIVKLHEVFHD-----QLHTFLVMELLNGGELFERIKKKKH--FSETEASYIMRKLVSAV 119 Query: 129 DFLHANCIVHRDLKPENILV---TSGGTVKLADFGLARIYSYQMA-LTPVVVTLWYRAPE 184 +H +VHRDLKPEN+L +K+ DFG AR+ L TL Y APE Sbjct: 120 SHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCFTLHYAAPE 179 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244 +L Q+ Y D+WS+G I M + F + + +++ + Sbjct: 180 LLNQNGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMK-----------KI 228 Query: 245 PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH---KDEGN 301 +G F G + + L+ +LT +P+KR+ + +L + N Sbjct: 229 KKGDFSFEG-----EAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSN 283 Query: 302 P 302 P Sbjct: 284 P 284 >6ED6-A nrPDB Length = 415 Score = 214 bits (545), Expect = 4e-56, Method: Composition-based stats. Identities = 70/308 (22%), Positives = 108/308 (35%), Gaps = 45/308 (14%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 M Y+ V IG GA+G V R S A+K + R++ Sbjct: 85 MKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDI--- 141 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 + P VV+L R + +V E++ ++ +P + K Sbjct: 142 --MAFANSPWVVQLFYAFQDDR-----YLYMVMEYMPGG--DLVNLMSNYDVPEKWAKFY 192 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ--MALTPVVVTL 178 + + LD +H+ ++HRD+KP+N+L+ G +KLADFG + V T Sbjct: 193 TAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTP 252 Query: 179 WYRAPEVLLQST----YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 Y +PEVL Y D WSVG EM F +S KI Sbjct: 253 DYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIM------- 305 Query: 235 EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI---SAFRALQ 291 D + P A E+ + L+ LT + R+ Q Sbjct: 306 --DHKNSLCFPEDA--------------EISKHAKNLICAFLT-DREVRLGRNGVEEIRQ 348 Query: 292 HSYLHKDE 299 H + D+ Sbjct: 349 HPFFKNDQ 356 >4WB7-A nrPDB Length = 405 Score = 214 bits (545), Expect = 4e-56, Method: Composition-based stats. Identities = 59/298 (19%), Positives = 107/298 (35%), Gaps = 47/298 (15%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 ++E + +G G++G V + +G+ A+K + T+ E + L Sbjct: 96 DQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQI--EHTLNEKRI---L 150 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMR 122 +A P +V+L + +V E+V ++ ++L + + Sbjct: 151 QAVNFPFLVKL-----EFSFKDNSNLYMVMEYVPGGEMFSHLRRIGR--FSEPHARFYAA 203 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 Q + ++LH+ +++RDLKPEN+L+ G +++ DFG A+ + T Y A Sbjct: 204 QIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK--GRTWTLCGTPEYLA 261 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 PE++L Y VD W++G + EM P F + KI P Sbjct: 262 PEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSH------ 315 Query: 243 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-----SAFRALQHSYL 295 LL +L + KR H + Sbjct: 316 ---------------------FSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 352 >5DBX-A nrPDB Length = 328 Score = 214 bits (545), Expect = 4e-56, Method: Composition-based stats. Identities = 72/314 (22%), Positives = 117/314 (37%), Gaps = 43/314 (13%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + YE IG GA V A VA+K + + ++E+ + Sbjct: 8 ICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMD----ELLKEIQAM 63 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDK-------APPPGLP 113 + HPNVV + ++ LV + + + K L Sbjct: 64 SQCS---HPNVVTYYTSFVV-----KDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLE 115 Query: 114 AETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALT- 172 I ++++ L GLD+LH N +HRDLK NIL+ G+V++ADFG++ + +T Sbjct: 116 EAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTR 175 Query: 173 -----PVVVTLWYRAPEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI 226 V T + APEV+ Q Y DMWS G E+ + L + Sbjct: 176 NKVRKDFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVL--M 233 Query: 227 FDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISA 286 L PP + ++ + +S +LL L +P KR +A Sbjct: 234 LTLQNDPP---------------TLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTA 278 Query: 287 FRALQHSYLHKDEG 300 L+ + K + Sbjct: 279 AELLKCKFFQKAKN 292 >1U5R-A nrPDB Length = 348 Score = 214 bits (545), Expect = 4e-56, Method: Composition-based stats. Identities = 75/297 (25%), Positives = 118/297 (39%), Gaps = 42/297 (14%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 + + EIG G++G VY ARD + VA+K + G ++EV L++L Sbjct: 56 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSY--SGKQSNEKWQDIIKEVRFLQKLR- 112 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 HPN ++ T LV E+ L+ P L I + L Sbjct: 113 --HPNTIQYRGCYLREHTA-----WLVMEYCLGSASDLLEVHKKP-LQEVEIAAVTHGAL 164 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 +GL +LH++ ++HRD+K NIL++ G VKL DFG A I + V T ++ APEV Sbjct: 165 QGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAP---ANSFVGTPYWMAPEV 221 Query: 186 LL---QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 +L + Y VD+WS+G E+ RKP + L I + Sbjct: 222 ILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGH---- 277 Query: 243 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE 299 E + L P R ++ L+H ++ ++ Sbjct: 278 ---------------------WSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRER 313 >4YNZ-A nrPDB Length = 342 Score = 214 bits (545), Expect = 4e-56, Method: Composition-based stats. Identities = 76/300 (25%), Positives = 118/300 (39%), Gaps = 42/300 (14%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y +G G G V + VA+K V N + + RE+A+L+ + Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIV---NREKLSESVLMKVEREIAILKLI-- 66 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLMRQF 124 EHP+V++L DV + + LV EHV L YL K L + + RQ Sbjct: 67 -EHPHVLKLHDVYENKK-----YLYLVLEHVSGGELFDYLVKKGR--LTPKEARKFFRQI 118 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 + LDF H++ I HRDLKPEN+L+ +++ADFG+A + L + Y PE Sbjct: 119 ISALDFCHSHSICHRDLKPENLLLDERNNIRIADFGMASLQVGDSLLETSCGSPHYACPE 178 Query: 185 VLLQSTYA-TPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 V+ Y D+WS G I + F ++ L K+ + P P S Sbjct: 179 VIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQS 238 Query: 244 LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 303 LL M+ + +R++ +H + + PE Sbjct: 239 ---------------------------LLRGMIEVDAARRLTLEHIQKHIWYIGGKNEPE 271 >4J52-A nrPDB Length = 293 Score = 213 bits (544), Expect = 5e-56, Method: Composition-based stats. Identities = 66/286 (23%), Positives = 104/286 (36%), Gaps = 39/286 (13%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G G + ++ D + A K V P E+++ R L H +V Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIV--PKSLLLKPHQREKMSMEISIHRSLA---HQHV 76 Query: 72 VRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFL 131 V + V +V E + L K L + +RQ + G +L Sbjct: 77 VGFHGFFEDNDF-----VFVVLELCRRRSLLELHKRRK-ALTEPEARYYLRQIVLGCQYL 130 Query: 132 HANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPV-VVTLWYRAPEVLLQST 190 H N ++HRDLK N+ + VK+ DFGLA Y V T Y APEVL + Sbjct: 131 HRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLSKKG 190 Query: 191 YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFP 250 ++ VD+WS+GCI + KP F + + +I Sbjct: 191 HSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRI------------------------ 226 Query: 251 PRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 + S+ + A L+ +ML +P R + L + Sbjct: 227 ---KKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFT 269 >2WQN-A nrPDB Length = 310 Score = 213 bits (544), Expect = 6e-56, Method: Composition-based stats. Identities = 71/284 (25%), Positives = 121/284 (42%), Gaps = 37/284 (13%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 + +IG G + VY+A G VALK V++ + ++E+ LL++L Sbjct: 33 NFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQIFDLMDAKA--RADCIKEIDLLKQL- 89 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLD--KAPPPGLPAETIKDLM 121 HPNV++ + ++ +V E D DL + K +P T+ Sbjct: 90 --NHPNVIKYYASFI-----EDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYF 142 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY-QMALTPVVVTLWY 180 Q L+ +H+ ++HRD+KP N+ +T+ G VKL D GL R +S A +V T +Y Sbjct: 143 VQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYY 202 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 +PE + ++ Y D+WS+GC+ EM + F G+ + + Sbjct: 203 MSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKM----------------NLYSL 246 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI 284 + + +PP E QL+ + +P KR Sbjct: 247 CKKIEQCDYPPLP-------SDHYSEELRQLVNMCINPDPEKRP 283 >6CKI-A nrPDB Length = 316 Score = 213 bits (542), Expect = 9e-56, Method: Composition-based stats. Identities = 73/316 (23%), Positives = 121/316 (38%), Gaps = 44/316 (13%) Query: 3 TSRYEPV-----AEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREV 57 + R+E V +G GA+ V + + A+K + G + REV Sbjct: 7 SGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKII-----EKQPGHIRSRVFREV 61 Query: 58 ALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAET 116 +L + + H NV + + E + LVFE + + +++ K Sbjct: 62 EMLYQCQG--HRNV-----LELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRH--FNELE 112 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGT---VKLADFGLARIYSYQMALTP 173 +++ LDFLH I HRDLKPENIL VK+ DFGL +P Sbjct: 113 ASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSP 172 Query: 174 V--------VVTLWYRAPEVL-----LQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEA 220 + + Y APEV+ S Y D+WS+G I + P F G + Sbjct: 173 ISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGS 232 Query: 221 DQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNP 280 D G ++ + + FP + + + L+ ++L + Sbjct: 233 D-CGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISC-------AAKDLISKLLVRDA 284 Query: 281 HKRISAFRALQHSYLH 296 +R+SA + LQH ++ Sbjct: 285 KQRLSAAQVLQHPWVQ 300 >5LOH-A nrPDB Length = 341 Score = 213 bits (542), Expect = 9e-56, Method: Composition-based stats. Identities = 64/304 (21%), Positives = 111/304 (36%), Gaps = 46/304 (15%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 + + V I GA+G VY + G A+K V+ + + R+ Sbjct: 34 SIEEFSIVKPISRGAFGKVYLGQK--GGKLYAVKVVKKADMINKNMTHQVQAERDA---- 87 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDL 120 L + P +V L ++ V LV E++ D+++ L E Sbjct: 88 -LALSKSPFIVHLYYSLQSANN-----VYLVMEYLIGGDVKSLLHIYGY--FDEEMAVKY 139 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-------YSYQMALTP 173 + + LD+LH + I+HRDLKP+N+L+++ G +KL DFGL+++ + Sbjct: 140 ISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTRT 199 Query: 174 VVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 233 T Y APE+LL + VD W++G E P F + I Sbjct: 200 FCGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNIL------ 253 Query: 234 PEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHS 293 + P ++ ++ + +LT + KR +H Sbjct: 254 ------------------KRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHP 295 Query: 294 YLHK 297 Sbjct: 296 LFSD 299 >2GCD-A nrPDB Length = 309 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 75/297 (25%), Positives = 118/297 (39%), Gaps = 42/297 (14%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 + + EIG G++G VY ARD + VA+K + G ++EV L++L Sbjct: 17 FSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSY--SGKQSNEKWQDIIKEVRFLQKLR- 73 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 HPN ++ T LV E+ L+ P L I + L Sbjct: 74 --HPNTIQYRGCYLREHTA-----WLVMEYCLGSASDLLEVHKKP-LQEVEIAAVTHGAL 125 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 +GL +LH++ ++HRD+K NIL++ G VKL DFG A I + V T ++ APEV Sbjct: 126 QGLAYLHSHNMIHRDVKAGNILLSEPGLVKLGDFGSASIMAP---ANSFVGTPYWMAPEV 182 Query: 186 LL---QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 +L + Y VD+WS+G E+ RKP + L I + Sbjct: 183 ILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGH---- 238 Query: 243 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE 299 E + L P R ++ L+H ++ ++ Sbjct: 239 ---------------------WSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFVLRER 274 >5YV8-A nrPDB Length = 298 Score = 212 bits (540), Expect = 1e-55, Method: Composition-based stats. Identities = 73/322 (22%), Positives = 130/322 (40%), Gaps = 58/322 (18%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLP---------- 50 + ++Y EIG G+YG V A + + + A+K + G Sbjct: 10 VQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPA 69 Query: 51 -----------ISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD 99 +E+A+L++L +HPNVV+L++V D + +VFE V+Q Sbjct: 70 PGGCIQPRGPIEQVYQEIAILKKL---DHPNVVKLVEVLDDPNED---HLYMVFELVNQG 123 Query: 100 LRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADF 159 ++ L + + + ++G+++LH I+HRD+KP N+LV G +K+ADF Sbjct: 124 --PVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADF 181 Query: 160 GLARIYSYQMA-LTPVVVTLWYRAPEVLLQST---YATPVDMWSVGCIFAEMFRRKPLFC 215 G++ + A L+ V T + APE L ++ +D+W++G + F Sbjct: 182 GVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF- 240 Query: 216 GNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEM 275 +I + FP + P++ E L+ M Sbjct: 241 ------MDERIM---------CLHSKIKSQALEFPDQ---------PDIAEDLKDLITRM 276 Query: 276 LTFNPHKRISAFRALQHSYLHK 297 L NP RI H ++ + Sbjct: 277 LDKNPESRIVVPEIKLHPWVTR 298 >6QAU-A nrPDB Length = 280 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 80/304 (26%), Positives = 123/304 (40%), Gaps = 49/304 (16%) Query: 5 RYEPVAEIGVGAYGTVYKARDP-HSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 Y +G GA+ V++ R + VA+KS+ N I +E+ +L+ L Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKS----QILLGKEIKILKEL 67 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMR 122 +H N+V L DV + V LV E+ DL YL L +TI+ + Sbjct: 68 ---QHENIVALYDVQELPNS-----VFLVMEYCNGGDLADYLQ--AKGTLSEDTIRVFLH 117 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVT---------SGGTVKLADFGLARIYSYQMALTP 173 Q + LH+ I+HRDLKP+NIL++ SG +K+ADFG AR M Sbjct: 118 QIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAAD 177 Query: 174 VVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 233 + + Y APEV++ Y D+WS+G + + KP F NS D + + Sbjct: 178 LCGSPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQD--------LRMF 229 Query: 234 PEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHS 293 E + S+PR P + + N R+ H Sbjct: 230 YEKNRSLMPSIPRETSPYLANLLLGLL----------------QRNQKDRMDFEAFFSHP 273 Query: 294 YLHK 297 +L + Sbjct: 274 FLEQ 277 >3NYO-A nrPDB Length = 576 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 64/298 (21%), Positives = 108/298 (36%), Gaps = 39/298 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 + +G G +G V + +G A ++ + E +L ++ + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYA--CKKLEKKRIKKRKGEAMALNEKQILEKVNS 243 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQF 124 VV L T + LV + DL+ ++ G P + Sbjct: 244 ---RFVVSLAYAYETKDA-----LCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEI 295 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 GL+ LH IV+RDLKPENIL+ G ++++D GLA + V T+ Y APE Sbjct: 296 CCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPE 355 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244 V+ Y D W++GC+ EM + F + + ++ L+ PE+ Sbjct: 356 VVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEE-------- 407 Query: 245 PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-----SAFRALQHSYLHK 297 L ++L +P +R+ SA +H K Sbjct: 408 ---------------YSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKK 450 >2PVN-A nrPDB Length = 352 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 75/307 (24%), Positives = 135/307 (43%), Gaps = 30/307 (9%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 YE V ++G G Y V++ + ++ RE+ +L+ L Sbjct: 52 DDYEVVRKVGRGKYSEVFEGINVNNNEKC--------IIKILKPVKKKKIKREIKILQNL 103 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 PN+V+L+D+ + L+FE+V+ L P L I+ + + Sbjct: 104 CGG--PNIVKLLDIVRDQHSKTPS---LIFEYVNNTDFKVL----YPTLTDYDIRYYIYE 154 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSG-GTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 L+ LD+ H+ I+HRD+KP N+++ ++L D+GLA Y V + +++ Sbjct: 155 LLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKG 214 Query: 183 PEVLLQ-STYATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 PE+L+ Y +DMWS+GC+FA M FR++P F G+ DQL KI ++G + + Sbjct: 215 PELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLN 274 Query: 241 DVSLP----------RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRAL 290 + R + P + L ++L ++ +R++A A+ Sbjct: 275 KYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAM 334 Query: 291 QHSYLHK 297 H Y + Sbjct: 335 THPYFQQ 341 >3A8W-A nrPDB Length = 345 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 67/304 (22%), Positives = 115/304 (37%), Gaps = 37/304 (12%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + ++ + IG G+Y V R + A+K V+ + T + V Sbjct: 6 LGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDWVQTEKHVFE- 64 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKD 119 +A HP +V L T E ++ V E+V DL ++ + LP E + Sbjct: 65 ---QASNHPFLVGLHSCFQT-----ESRLFFVIEYVNGGDLMFHMQRQRK--LPEEHARF 114 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-YSYQMALTPVVVTL 178 + L++LH I++RDLK +N+L+ S G +KL D+G+ + + T Sbjct: 115 YSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTP 174 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y APE+L Y VD W++G + EM + F D++G D Sbjct: 175 NYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF-------------DIVGSSDNPDQ 221 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISA------FRALQH 292 + L + + P + A +L L +P +R+ H Sbjct: 222 NTEDYLFQVILEKQIRIPRS-----LSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGH 276 Query: 293 SYLH 296 + Sbjct: 277 PFFR 280 >6CQF-A nrPDB Length = 297 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 72/299 (24%), Positives = 116/299 (38%), Gaps = 40/299 (13%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 Y+ + +G G YG V+KARD SG VALK V++ + +E+ +L+ Sbjct: 16 DHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKM-----EPDDDVSTLQKEILILKTC 70 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 H N+V K+ + E + + L I + R+ Sbjct: 71 R---HANIVAYHGSYL-----WLQKLWICMEFCGAGSLQDIYQVTG-SLSELQISYVCRE 121 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALT-PVVVTLWYRA 182 L+GL +LH+ +HRD+K NIL+ G V+LADFG++ +A + T ++ A Sbjct: 122 VLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLAFIGTPYWMA 181 Query: 183 PEVL---LQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 PEV L+ Y D+WS+G E+ +P L + PP Sbjct: 182 PEVAAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEK 241 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + + + LT +P KR SA + L H + + Sbjct: 242 G----------------------KWSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQP 278 >6E9W-A nrPDB Length = 443 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 65/308 (21%), Positives = 107/308 (34%), Gaps = 45/308 (14%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 M YE V IG GA+G V R + A+K + R++ Sbjct: 99 MKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDI--- 155 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 + P VV+L R + +V E++ ++ +P + + Sbjct: 156 --MAFANSPWVVQLFYAFQDDR-----YLYMVMEYMPGG--DLVNLMSNYDVPEKWARFY 206 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALT--PVVVTL 178 + + LD +H+ +HRD+KP+N+L+ G +KLADFG + + + V T Sbjct: 207 TAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTP 266 Query: 179 WYRAPEVLLQST----YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 Y +PEVL Y D WSVG EM F +S KI + Sbjct: 267 DYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLT 326 Query: 235 EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI---SAFRALQ 291 D ++ + L+ LT + R+ + Sbjct: 327 FPD-----------------------DNDISKEAKNLICAFLT-DREVRLGRNGVEEIKR 362 Query: 292 HSYLHKDE 299 H + D+ Sbjct: 363 HLFFKNDQ 370 >6EII-A nrPDB Length = 352 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 79/305 (25%), Positives = 132/305 (43%), Gaps = 30/305 (9%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 Y+ V ++G G Y V++A + + RE+ +L L Sbjct: 60 DDYQLVRKLGRGKYSEVFEAINITNNEK--------VVVKILKPVKKKKIKREIKILENL 111 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 PN++ L D+ + LVFEHV+ L + L I+ M + Sbjct: 112 RGG--PNIITLADIVKDPVSRTPA---LVFEHVNNTDFKQLYQ----TLTDYDIRFYMYE 162 Query: 124 FLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 L+ LD+ H+ I+HRD+KP N+++ ++L D+GLA Y V + +++ Sbjct: 163 ILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKG 222 Query: 183 PEVL-LQSTYATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGLPPEDDW-- 238 PE+L Y +DMWS+GC+ A M FR++P F G+ DQL +I ++G D+ Sbjct: 223 PELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYID 282 Query: 239 -------PRDVSLPRGAFPPRGPRPVQSVVPEM-EESGAQLLLEMLTFNPHKRISAFRAL 290 PR + R R V S + L ++L ++ R++A A+ Sbjct: 283 KYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAM 342 Query: 291 QHSYL 295 +H Y Sbjct: 343 EHPYF 347 >5DYK-A nrPDB Length = 853 Score = 210 bits (536), Expect = 5e-55, Method: Composition-based stats. Identities = 77/302 (25%), Positives = 110/302 (36%), Gaps = 46/302 (15%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + E IG G +GTV + ALK V + I RE+ Sbjct: 536 VEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREIT-- 593 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKD 119 +HP ++RL+ S+ + E V +L + K L + Sbjct: 594 ---AENDHPFIIRLVRTFKDSK-----YFYFLTELVTGGELYDAIRKLGL--LSKSQAQF 643 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLW 179 + + +++LH IV+RDLKPENIL+ G VKL DFG A+ Q +V T Sbjct: 644 YLGSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKV--QGRAYTLVGTPH 701 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLI-GLPPEDDW 238 Y APEV+L Y VD+W++G E F GN E DQL D++ G D+ Sbjct: 702 YMAPEVILGKGYGCTVDIWALGICLYEFICGPLPF-GNDEEDQLEIFRDILTGQLTFPDY 760 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISA-----FRALQHS 293 D L+ +L P RI H Sbjct: 761 VTDT------------------------DSINLMKRLLCRLPQGRIGCSINGFKDIKDHP 796 Query: 294 YL 295 + Sbjct: 797 FF 798 >4RA4-A nrPDB Length = 355 Score = 210 bits (534), Expect = 7e-55, Method: Composition-based stats. Identities = 60/306 (19%), Positives = 112/306 (36%), Gaps = 45/306 (14%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + + + + +G G++G V A + A+K ++ E +L Sbjct: 17 VKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMV--EKRVL 74 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKD 119 L+ P + +L T ++ V E+V DL ++ + Sbjct: 75 ALLDKP--PFLTQLHSCFQT-----VDRLYFVMEYVNGGDLMYHIQQVGK--FKEPQAVF 125 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALT-PVVVTL 178 + GL FLH I++RDLK +N+++ S G +K+ADFG+ + + T T Sbjct: 126 YAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTP 185 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y APE++ Y VD W+ G + EM +P F G E + I + Sbjct: 186 DYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIME---------- 235 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISA-----FRALQHS 293 S + + + ++T +P KR+ +H+ Sbjct: 236 -----------------HNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHA 278 Query: 294 YLHKDE 299 + + + Sbjct: 279 FFRRID 284 >6HMD-A nrPDB Length = 365 Score = 210 bits (534), Expect = 8e-55, Method: Composition-based stats. Identities = 75/305 (24%), Positives = 130/305 (42%), Gaps = 30/305 (9%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 Y+ V ++G G Y V++A + + REV +L L Sbjct: 53 DDYQLVRKLGRGKYSEVFEAINITNNE--------RVVVKILKPVKKKKIKREVKILENL 104 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 N+++L+D + LVFE+++ L + L I+ M + Sbjct: 105 RGGT--NIIKLIDTVKDPVSKTPA---LVFEYINNTDFKQLYQI----LTDFDIRFYMYE 155 Query: 124 FLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 L+ LD+ H+ I+HRD+KP N+++ ++L D+GLA Y V + +++ Sbjct: 156 LLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKG 215 Query: 183 PEVL-LQSTYATPVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGLPPEDDW-- 238 PE+L Y +DMWS+GC+ A M FRR+P F G DQL +I ++G + Sbjct: 216 PELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLK 275 Query: 239 -------PRDVSLPRGAFPPRGPRPVQSVVPEM-EESGAQLLLEMLTFNPHKRISAFRAL 290 P + R + S + LL ++L ++ +R++A A+ Sbjct: 276 KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAM 335 Query: 291 QHSYL 295 +H Y Sbjct: 336 EHPYF 340 >5MJB-A nrPDB Length = 305 Score = 209 bits (533), Expect = 9e-55, Method: Composition-based stats. Identities = 66/285 (23%), Positives = 113/285 (39%), Gaps = 28/285 (9%) Query: 7 EPVAEIGVGAYGTVYKARDPHSGH---FVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 + IG G +G VYK R G +VA+K+++ G + E +++ + Sbjct: 29 KIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLK----AGYSEKQRRDFLSEASIMGQ- 83 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 F+H N++RL V SR V ++ E ++ + + ++R Sbjct: 84 --FDHRNIIRLEGVVTKSRP-----VMIITEFMENCALDSFLRQNDGQFTVIQLVGMLRG 136 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA---LTPVVV---T 177 G+ +L VHRDL NILV S K++DFGL+R + T + Sbjct: 137 IAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIP 196 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPED 236 + + APE + + + D+WS G + E+ + + S D + I LPP Sbjct: 197 VRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPM 256 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPH 281 D P + + ++ P E L +M+ NP Sbjct: 257 DCPAALH----QLMLDCWQKDRNSRPRFAEIVNTL-DKMIR-NPA 295 >5L6P-A nrPDB Length = 298 Score = 208 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 65/285 (22%), Positives = 112/285 (39%), Gaps = 28/285 (9%) Query: 7 EPVAEIGVGAYGTVYKARDPHSGHF---VALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 + IG G +G V + R G VA+K+++V G + E +++ + Sbjct: 22 KIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKV----GYTERQRRDFLSEASIMGQ- 76 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 F+HPN++RL V SR V ++ E ++ + + ++R Sbjct: 77 --FDHPNIIRLEGVVTKSRP-----VMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRG 129 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA---LTPVVV---T 177 G+ +L VHRDL NILV S K++DFGL+R + T + Sbjct: 130 IAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIP 189 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAE-MFRRKPLFCGNSEADQLGKIFDLIGLPPED 236 + + APE + + + D+WS G + E M + + S D + + LPP Sbjct: 190 IRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPM 249 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPH 281 D P + +++ P+ + L L NP Sbjct: 250 DCPTALH----QLMLDCWVRDRNLRPKFSQIVNTLDK--LIRNPA 288 >4GS6-A nrPDB Length = 315 Score = 208 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 78/291 (26%), Positives = 118/291 (40%), Gaps = 51/291 (17%) Query: 7 EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF 66 E +G GA+G V KA+ VA+K + + + LR+L Sbjct: 12 EVEEVVGRGAFGVVCKAKWRA--KDVAIKQIESESERKA----------FIVELRQLSRV 59 Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPP-PGLPAETIKDLMRQF 124 HPN+V+L C V LV E+ + L L A P P A Q Sbjct: 60 NHPNIVKLYGACLN-------PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQC 112 Query: 125 LRGLDFLHANC---IVHRDLKPENILVTSGGTV-KLADFGLARIYSYQMALTPVVVTLWY 180 +G+ +LH+ ++HRDLKP N+L+ +GGTV K+ DFG A Q +T + + Sbjct: 113 SQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTA--CDIQTHMTNNKGSAAW 170 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 APEV S Y+ D++S G I E+ R+ F D IG P Sbjct: 171 MAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPF-------------DEIGGPAFRIMWA 217 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 + R P+P++S L+ + +P +R S ++ Sbjct: 218 VHNGTRPPLIKNLPKPIES-----------LMTRCWSKDPSQRPSMEEIVK 257 >5FET-A nrPDB Length = 847 Score = 208 bits (530), Expect = 2e-54, Method: Composition-based stats. Identities = 77/295 (26%), Positives = 113/295 (38%), Gaps = 44/295 (14%) Query: 7 EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF 66 E IG G +GTV + ALK V + I RE+ Sbjct: 536 ETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQQNNIKLEREIT-----AEN 590 Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 +HP ++RL+ S + E V +L + K L + + + Sbjct: 591 DHPFIIRLVRTFKDSN-----CFYFLTELVTGGELYDAIRKLGL--LSKPQAQFYLGSII 643 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 +++LH IV+RDLKPENIL+ G VKL DFG A+ Q +V T Y APEV Sbjct: 644 LAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKI--QGRAYTLVGTPHYMAPEV 701 Query: 186 LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP 245 +L Y VD+W++G E F GN + DQL D+ L + +P VS Sbjct: 702 ILGKGYGCTVDIWALGVCLYEFICGPLPF-GNDQEDQLEIFRDI--LTGQLTFPDYVS-- 756 Query: 246 RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISA-----FRALQHSYL 295 ++ L+ +L P RI +H++ Sbjct: 757 -------------------DQDSINLMKRLLCRLPQGRIGCSINGFKDIKEHAFF 792 >2H8H-A nrPDB Length = 535 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 63/299 (21%), Positives = 114/299 (38%), Gaps = 50/299 (16%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 ++G G +G V+ + VA+K+++ G P + ++E ++++L H Sbjct: 274 KLGQGCFGEVWMGTWNGT-TRVAIKTLK------PGTMSPEAFLQEAQVMKKLR---HEK 323 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 +V+L V + E + +V E++ L +L L + D+ Q G+ Sbjct: 324 LVQLYAVVS------EEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMA 377 Query: 130 FLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY--QMALTPVVVTLWYRAPEVLL 187 ++ VHRDL+ NILV K+ADFGLAR+ A + + APE L Sbjct: 378 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 437 Query: 188 QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPR 246 + D+WS G + E+ + + G + L ++ +P + P Sbjct: 438 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP------- 490 Query: 247 GAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAF--RALQHSYLHKDEGNPE 303 ES L+ + P +R + +A Y P+ Sbjct: 491 -------------------ESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFT--STEPQ 528 >3ORZ-A nrPDB Length = 316 Score = 207 bits (528), Expect = 4e-54, Method: Composition-based stats. Identities = 64/303 (21%), Positives = 116/303 (38%), Gaps = 49/303 (16%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 ++ +G G++ TV AR+ + A+K + + ++ RE ++ RL Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVT--RERDVMSRL 94 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMR 122 +HP V+L K+ + + +L Y+ K + Sbjct: 95 ---DHPFFVKLYFCFQDDE-----KLYFGLSYAKNGELLKYIRKIG--SFDETCTRFYTA 144 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL---TPVVVTLW 179 + + L++LH I+HRDLKPENIL+ +++ DFG A++ S + V T Sbjct: 145 EIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQ 204 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 Y +PE+L + + D+W++GCI ++ P F +E KI L PE +P Sbjct: 205 YVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFP 264 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFR------ALQHS 293 + L+ ++L + KR+ H Sbjct: 265 K---------------------------ARDLVEKLLVLDATKRLGCEEMEGYGPLKAHP 297 Query: 294 YLH 296 + Sbjct: 298 FFE 300 >2FO0-A nrPDB Length = 495 Score = 206 bits (525), Expect = 9e-54, Method: Composition-based stats. Identities = 58/286 (20%), Positives = 108/286 (37%), Gaps = 44/286 (15%) Query: 8 PVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 ++G G YG VY+ VA+K+++ ++E A+++ ++ Sbjct: 221 MKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEV------EEFLKEAAVMKEIK--- 271 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLR 126 HPN+V+L+ VC RE ++ E + +L YL + + A + + Q Sbjct: 272 HPNLVQLLGVCT-----REPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISS 326 Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY--SYQMALTPVVVTLWYRAPE 184 +++L +HR+L N LV VK+ADFGL+R+ A + + APE Sbjct: 327 AMEYLEKKNFIHRNLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPE 386 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 L + ++ D+W+ G + E+ + G + + + + P Sbjct: 387 SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP---- 442 Query: 244 LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 E +L+ +NP R S Sbjct: 443 ----------------------EKVYELMRACWQWNPSDRPSFAEI 466 >2WTK-C nrPDB Length = 305 Score = 206 bits (525), Expect = 9e-54, Method: Composition-based stats. Identities = 77/302 (25%), Positives = 125/302 (41%), Gaps = 39/302 (12%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 +Y +G G+YG V + D + A+ + + +E+ LLRR Sbjct: 4 IGKYLMGDLLGEGSYGKVKEVLDSETLCRRAV-KILKKKKLRRIPNGEANVKKEIQLLRR 62 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L H NV++L+DV + + K+ +V E+ ++ LD P P Sbjct: 63 LR---HKNVIQLVDVL---YNEEKQKMYMVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFC 116 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY---QMALTPVVVTLW 179 Q + GL++LH+ IVH+D+KP N+L+T+GGT+K++ G+A + Sbjct: 117 QLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISALGVAEALHPFAADDTCRTSQGSPA 176 Query: 180 YRAPEVL--LQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 ++ PE+ L + VD+WS G + F G D + K+F+ IG Sbjct: 177 FQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEG----DNIYKLFENIG------ 226 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 ++P PP LL ML + P KR S + QHS+ K Sbjct: 227 -KGSYAIPGDCGPPLS----------------DLLKGMLEYEPAKRFSIRQIRQHSWFRK 269 Query: 298 DE 299 Sbjct: 270 KH 271 >6F3F-A nrPDB Length = 455 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 63/299 (21%), Positives = 115/299 (38%), Gaps = 50/299 (16%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 ++G G +G V+ + VA+K+++ G P + ++E ++++L H Sbjct: 194 KLGQGCFGEVWMGTWNGT-TRVAIKTLK------PGTMSPEAFLQEAQVMKKLR---HEK 243 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 +V+L V + E + +V E+++ L +L L + D+ Q G+ Sbjct: 244 LVQLYAVVS------EEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMA 297 Query: 130 FLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY--QMALTPVVVTLWYRAPEVLL 187 ++ VHRDL+ NILV K+ADFGLAR+ A + + APE L Sbjct: 298 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 357 Query: 188 QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPR 246 + D+WS G + E+ + + G + L ++ +P + P Sbjct: 358 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP------- 410 Query: 247 GAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAF--RALQHSYLHKDEGNPE 303 ES L+ + P +R + +A Y P+ Sbjct: 411 -------------------ESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFT--STEPQ 448 >4EBW-A nrPDB Length = 304 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 62/293 (21%), Positives = 109/293 (37%), Gaps = 47/293 (16%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSG---HFVALKSVRVPNGGGGGGGLPISTVREVALL 60 R E IG G +G V++ VA+K+ + + ++E + Sbjct: 38 ERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCK----NCTSDSVREKFLQEALTM 93 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKD 119 R+ F+HP++V+L+ V E V ++ E +LR++L + L ++ Sbjct: 94 RQ---FDHPHIVKLIGVIT------ENPVWIIMELCTLGELRSFL-QVRKYSLDLASLIL 143 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV--T 177 Q L +L + VHRD+ N+LV+S VKL DFGL+R Sbjct: 144 YAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLP 203 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPED 236 + + APE + + + D+W G E+ F G D +G+I + LP Sbjct: 204 IKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPP 263 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 + P + L+ + ++P +R Sbjct: 264 NCP--------------------------PTLYSLMTKCWAYDPSRRPRFTEL 290 >2DQ7-X nrPDB Length = 283 Score = 205 bits (523), Expect = 1e-53, Method: Composition-based stats. Identities = 61/283 (21%), Positives = 115/283 (40%), Gaps = 46/283 (16%) Query: 7 EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF 66 + + +G G +G V+ + VA+K+++ G P S + E ++++L+ Sbjct: 12 QLIKRLGNGQFGEVWMGTW-NGNTKVAIKTLK------PGTMSPESFLEEAQIMKKLK-- 62 Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFL 125 H +V+L V + E + +V E+++ L +L L + D+ Q Sbjct: 63 -HDKLVQLYAVVS------EEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVA 115 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY--QMALTPVVVTLWYRAP 183 G+ ++ +HRDL+ NILV +G K+ADFGLAR+ A + + AP Sbjct: 116 AGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAP 175 Query: 184 EVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 E L + D+WS G + E+ + + G + + L ++ +P D P Sbjct: 176 EAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPI-- 233 Query: 243 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 S +L++ +P +R + Sbjct: 234 ------------------------SLHELMIHCWKKDPEERPT 252 >4XEY-B nrPDB Length = 408 Score = 205 bits (523), Expect = 1e-53, Method: Composition-based stats. Identities = 59/286 (20%), Positives = 108/286 (37%), Gaps = 44/286 (15%) Query: 8 PVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 ++G G YG VY+ VA+K+++ ++E A+++ ++ Sbjct: 129 MKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEV------EEFLKEAAVMKEIK--- 179 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLR 126 HPN+V+L+ VC RE ++ E + +L YL + + A + + Q Sbjct: 180 HPNLVQLLGVCT-----REPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISS 234 Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY--SYQMALTPVVVTLWYRAPE 184 +++L +HRDL N LV VK+ADFGL+R+ A + + APE Sbjct: 235 AMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPE 294 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 L + ++ D+W+ G + E+ + G + + + + P Sbjct: 295 SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP---- 350 Query: 244 LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 E +L+ +NP R S Sbjct: 351 ----------------------EKVYELMRACWQWNPSDRPSFAEI 374 >4P5Q-A nrPDB Length = 361 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 63/281 (22%), Positives = 114/281 (40%), Gaps = 26/281 (9%) Query: 8 PVAEIGVGAYGTVYKARDPHSGHF---VALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 +G G +G V R VA+K+++V G + E +++ + Sbjct: 37 IDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKV----GYTEKQRRDFLGEASIMGQ-- 90 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 F+HPN++RL V S+ V +V E+++ + + ++R Sbjct: 91 -FDHPNIIRLEGVVTKSKP-----VMIVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGI 144 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY--SYQMALTPVVV--TLWY 180 G+ +L VHRDL NIL+ S K++DFGL+R+ + A T + + Sbjct: 145 ASGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRW 204 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAE-MFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 +PE + + + D+WS G + E M + + S D + + + LPP D P Sbjct: 205 TSPEAIAYRKFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCP 264 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNP 280 + + ++ P+ E +L + L NP Sbjct: 265 AAL----YQLMLDCWQKDRNNRPKF-EQIVSILDK-LIRNP 299 >2VWV-A nrPDB Length = 302 Score = 205 bits (521), Expect = 2e-53, Method: Composition-based stats. Identities = 66/285 (23%), Positives = 111/285 (38%), Gaps = 28/285 (9%) Query: 7 EPVAEIGVGAYGTVYKARDPHSGHF---VALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 + IG G +G V + R G VA+K+++ GG + E +++ + Sbjct: 19 KIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLK----GGYTERQRREFLSEASIMGQ- 73 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 FEHPN++RL V S + V ++ E ++ + + ++R Sbjct: 74 --FEHPNIIRLEGVVTNS-----MPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRG 126 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY---SYQMALTPVVV---T 177 G+ +L VHRDL NILV S K++DFGL+R S T + Sbjct: 127 IASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTETSSLGGKIP 186 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPED 236 + + APE + + + D WS G + E+ + + S D + I LPP Sbjct: 187 IRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPP 246 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPH 281 D P + + ++ P L +M+ NP Sbjct: 247 DCPTSLH----QLMLDCWQKDRNARPRF-PQVVSALDKMIR-NPA 285 >1TKI-A nrPDB Length = 321 Score = 205 bits (521), Expect = 2e-53, Method: Composition-based stats. Identities = 61/298 (20%), Positives = 113/298 (37%), Gaps = 41/298 (13%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 +Y ++G G +G V++ + S K V+V G + +E+++ L Sbjct: 5 EKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVKVK------GTDQVLVKKEISI---L 55 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMR 122 H N++ L + + ++ ++FE + D+ ++ + L I + Sbjct: 56 NIARHRNILHLHESFESME-----ELVMIFEFISGLDIFERINTSAFE-LNEREIVSYVH 109 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTS--GGTVKLADFGLARIYSYQMALTPVVVTLWY 180 Q L FLH++ I H D++PENI+ + T+K+ +FG AR + Y Sbjct: 110 QVCEALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEY 169 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 APEV +T DMWS+G + + F + + I + E+ Sbjct: 170 YAPEVHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEE---- 225 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 E+ + +L R++A ALQH +L + Sbjct: 226 -------------------AFKEISIEAMDFVDRLLVKERKSRMTASEALQHPWLKQK 264 >4C0T-A nrPDB Length = 974 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 66/303 (21%), Positives = 113/303 (37%), Gaps = 49/303 (16%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 ++ E+G G+Y TV A D +G A+K + + ++ + L RL Sbjct: 267 DFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKYVNIEKHA--LNRLS 324 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQ 123 V+ L + + V ++ + +L T + + L E + Q Sbjct: 325 NRL--GVISLY-----FTFQDKDSLYFVLDYASNGELLTLIKRYN--TLNEECTRHFGAQ 375 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR----------IYSYQMALTP 173 L + ++H N ++HRDLKPENIL+ +++ DFG AR Y + Sbjct: 376 ILDAIKYMHDNGVIHRDLKPENILLDDKMRIQITDFGTARLLEKKNDESEEYPVDVRAKS 435 Query: 174 VVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 233 V T Y +PE+L P D+W+ GCI +M KP F +E KI + Sbjct: 436 FVGTAEYVSPELLENKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITK-LQFA 494 Query: 234 PEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHS 293 +P + L+ ++L P +R + +H Sbjct: 495 FSAGFPTIIR--------------------------DLIKKILVLQPSRRATIPEIQKHY 528 Query: 294 YLH 296 + Sbjct: 529 FFQ 531 >6BDL-A nrPDB Length = 347 Score = 204 bits (520), Expect = 3e-53, Method: Composition-based stats. Identities = 57/303 (18%), Positives = 108/303 (35%), Gaps = 44/303 (14%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDP-HSGHFVALKSVRVPNGGGGGGGLPISTVREVAL 59 + S + + +GVG +G V + A+K ++ + I + +++ Sbjct: 31 LKLSDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQI-- 88 Query: 60 LRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIK 118 ++ +VRL S+ + ++ E +L T L T + Sbjct: 89 ---MQGAHSDFIVRLYRTFKDSK-----YLYMLMEACLGGELWTILRDRG--SFEDSTTR 138 Query: 119 DLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTL 178 + +LH+ I++RDLKPEN+++ G KL DFG A+ + T Sbjct: 139 FYTACVVEAFAYLHSKGIIYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTP 198 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y APE++L + D WS+G + E+ P F G I I + Sbjct: 199 EYVAPEIILNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMI----- 253 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-----SAFRALQHS 293 ++ ++ A L+ ++ NP +R+ +H Sbjct: 254 --------------------EFPKKIAKNAANLIKKLCRDNPSERLGNLKNGVKDIQKHK 293 Query: 294 YLH 296 + Sbjct: 294 WFE 296 >2XNP-A nrPDB Length = 279 Score = 204 bits (520), Expect = 3e-53, Method: Composition-based stats. Identities = 76/302 (25%), Positives = 121/302 (40%), Gaps = 44/302 (14%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 YE + IG G+YG K R G + K + + G V EV LLR Sbjct: 5 AEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKEL---DYGSMTEAEKQMLVSEVNLLRE 61 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDK--APPPGLPAETIKD 119 L+ HPN+VR D + +V E+ + DL + + K L E + Sbjct: 62 LK---HPNIVRYYDRIIDRTN---TTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLR 115 Query: 120 LMRQFLRGLDFLHA-----NCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL-TP 173 +M Q L H + ++HRDLKP N+ + VKL DFGLARI ++ + Sbjct: 116 VMTQLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKT 175 Query: 174 VVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 233 V T +Y +PE + + +Y D+WS+GC+ E+ P F S+ + GKI + Sbjct: 176 FVGTPYYMSPEQMNRMSYNEKSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREG---- 231 Query: 234 PEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHS 293 + + + +++ ML + R S L++ Sbjct: 232 ----------------------KFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEILENP 269 Query: 294 YL 295 + Sbjct: 270 LI 271 >3VN9-A nrPDB Length = 340 Score = 204 bits (520), Expect = 3e-53, Method: Composition-based stats. Identities = 65/304 (21%), Positives = 113/304 (37%), Gaps = 44/304 (14%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + EP+ E+G GAYG V K R SG +A+K +R L + Sbjct: 48 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI----- 102 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKA--PPPGLPAETIK 118 + + P V RE V + E +D L + + +P + + Sbjct: 103 -SMRTVDCPFTVTFYGAL-----FREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILG 156 Query: 119 DLMRQFLRGLDFLHAN-CIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVT 177 + ++ L+ LH+ ++HRD+KP N+L+ + G VK+ DFG++ +A T Sbjct: 157 KIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGC 216 Query: 178 LWYRAPEVL----LQSTYATPVDMWSVGCIFAEMFRRKPLFCG-NSEADQLGKIFDLIGL 232 Y APE + Q Y+ D+WS+G E+ + + + QL ++ + Sbjct: 217 KPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE---- 272 Query: 233 PPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQH 292 P P D + + L N +R + +QH Sbjct: 273 EPSPQLPAD---------------------KFSAEFVDFTSQCLKKNSKERPTYPELMQH 311 Query: 293 SYLH 296 + Sbjct: 312 PFFT 315 >4FR4-A nrPDB Length = 384 Score = 204 bits (520), Expect = 3e-53, Method: Composition-based stats. Identities = 65/285 (22%), Positives = 110/285 (38%), Gaps = 38/285 (13%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 +E + IG G++G V + + A+K + + +E+ ++ Sbjct: 15 DHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEV--RNVFKELQIM--- 69 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 + EHP +V L D E +V + DLR +L + ET+K + + Sbjct: 70 QGLEHPFLVNLWYSFQ----DEEDMFMVVDLLLGGDLRYHLQQNVH--FKEETVKLFICE 123 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183 + LD+L I+HRD+KP+NIL+ G V + DF +A + + +T + T Y AP Sbjct: 124 LVMALDYLQNQRIIHRDMKPDNILLDEHGHVHITDFNIAAMLPRETQITTMAGTKPYMAP 183 Query: 184 EVLLQST---YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 E+ Y+ VD WS+G E+ R + + S Sbjct: 184 EMFSSRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRS---------------------- 221 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 S V + + LL ++L NP +R S Sbjct: 222 --STSSKEIVHTFETTVVTYPSAWSQEMVSLLKKLLEPNPDQRFS 264 >1JPA-A nrPDB Length = 312 Score = 204 bits (520), Expect = 3e-53, Method: Composition-based stats. Identities = 61/285 (21%), Positives = 106/285 (37%), Gaps = 28/285 (9%) Query: 7 EPVAEIGVGAYGTVYKARDPHSGHF---VALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 + IG G +G V G VA+K+++ G + E +++ + Sbjct: 36 KIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLK----SGYTEKQRRDFLSEASIMGQ- 90 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 F+HPNV+ L V S V ++ E ++ + + ++R Sbjct: 91 --FDHPNVIHLEGVVTKSTP-----VMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRG 143 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA---LTPVVV---T 177 G+ +L VHRDL NILV S K++DFGL+R + T + Sbjct: 144 IAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIP 203 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAE-MFRRKPLFCGNSEADQLGKIFDLIGLPPED 236 + + APE + + + D+WS G + E M + + + D + I LPP Sbjct: 204 IRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPM 263 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPH 281 D P + + + L +M+ NP+ Sbjct: 264 DCPSALHQLMLDCWQKDRNHRPKFGQIVNT-----LDKMIR-NPN 302 >4TNB-A nrPDB Length = 590 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 67/297 (22%), Positives = 106/297 (35%), Gaps = 39/297 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 + +G G +G V + +G A K + G + E +L ++ + Sbjct: 186 FRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKG--ESMALNEKQILEKVNS 243 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQF 124 VV L T + LV + DL+ ++ PG E + Sbjct: 244 Q---FVVNLAYAYETKDA-----LCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEI 295 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 L GL+ LH V+RDLKPENIL+ G ++++D GLA + V T+ Y APE Sbjct: 296 LCGLEDLHHENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPE 355 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244 VL Y D W +GC+ EM + F G E + Sbjct: 356 VLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKE-----------------------KV 392 Query: 245 PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-----SAFRALQHSYLH 296 R R + + E + +LT + +R+ A +H + Sbjct: 393 KREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFFR 449 >2Y6O-A nrPDB Length = 291 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 66/287 (22%), Positives = 116/287 (40%), Gaps = 28/287 (9%) Query: 7 EPVAEIGVGAYGTVYKARDPHSGHF---VALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 + IGVG +G V R G VA+K+++ G + E +++ + Sbjct: 17 KIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLK----AGYTDKQRRDFLSEASIMGQ- 71 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 F+HPN++ L V + V ++ E+++ + + ++R Sbjct: 72 --FDHPNIIHLEGVVTKCKP-----VMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRG 124 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY--SYQMALTPVVV--TLW 179 G+ +L VHRDL NILV S K++DFG++R+ + A T + Sbjct: 125 IGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIR 184 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAE-MFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 + APE + + + D+WS G + E M + + S D + I + LPP D Sbjct: 185 WTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDC 244 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPH--KR 283 P + + +S P+ +L + L NP+ KR Sbjct: 245 P----IALHQLMLDCWQKERSDRPKFG-QIVNMLDK-LIRNPNSLKR 285 >2X7G-A nrPDB Length = 389 Score = 203 bits (518), Expect = 5e-53, Method: Composition-based stats. Identities = 96/370 (25%), Positives = 149/370 (40%), Gaps = 83/370 (22%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + RY + ++G G + TV+ D FVA+K V+ + + E+ LL Sbjct: 28 LFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVK------SAQHYTETALDEIKLL 81 Query: 61 RRLEAFE--HPN---VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAE 115 + + + PN VV+L+D S + I V +VFE + L ++ K+ GLP Sbjct: 82 KCVRESDPSDPNKDMVVQLIDDFKISGMNG-IHVCMVFEVLGHHLLKWIIKSNYQGLPVR 140 Query: 116 TIKDLMRQFLRGLDFLHAN-CIVHRDLKPENILVTSGG---------------------- 152 +K ++RQ L+GLD+LH+ I+H D+KPENIL+ Sbjct: 141 CVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPS 200 Query: 153 -------------------------TVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLL 187 VK+AD G A T + T YR+ EVL+ Sbjct: 201 GSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVH--KHFTEDIQTRQYRSIEVLI 258 Query: 188 QSTYATPVDMWSVGCIFAEMFRRKPLFCGNS------EADQLGKIFDLIGLPPED----- 236 + Y+TP D+WS C+ E+ LF +S + D + I +L+G P Sbjct: 259 GAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSG 318 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEM-------EESGA---QLLLEMLTFNPHKRISA 286 + R+ RG S+ + E A L+ ML P KR SA Sbjct: 319 KYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASA 378 Query: 287 FRALQHSYLH 296 L+H +L+ Sbjct: 379 GECLRHPWLN 388 >2JD5-A nrPDB Length = 373 Score = 203 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 90/339 (26%), Positives = 150/339 (44%), Gaps = 47/339 (13%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 +RY V ++G G + TV+ A+D + VA+K VR G + E+ LL+ Sbjct: 17 KDARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVR------GDKVYTEAAEDEIKLLQ 70 Query: 62 RLEAFEHP--------NVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLP 113 R+ ++ ++++L+D + + V +VFE + ++L + K G+P Sbjct: 71 RVNDADNTKEDSMGANHILKLLDHFNHKGPNG-VHVVMVFEVLGENLLALIKKYEHRGIP 129 Query: 114 AETIKDLMRQFLRGLDFLHAN-CIVHRDLKPENILVTSGG------TVKLADFGLARIYS 166 +K + +Q L GLD++H I+H D+KPEN+L+ +K+AD G A Y Sbjct: 130 LIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWY- 188 Query: 167 YQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGN------SEA 220 T + T YR+PEVLL + + D+WS C+ E+ LF + + Sbjct: 189 -DEHYTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKDD 247 Query: 221 DQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGP---------RPVQSVVPEM----EES 267 D + +I +L+G P R+ R F RG P++ V+ E ++ Sbjct: 248 DHIAQIIELLGELPSY-LLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDE 306 Query: 268 GA---QLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 303 L ML +P KR A + H +L G E Sbjct: 307 AKEISDFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEE 345 >6NPU-A nrPDB Length = 298 Score = 203 bits (517), Expect = 7e-53, Method: Composition-based stats. Identities = 59/286 (20%), Positives = 108/286 (37%), Gaps = 44/286 (15%) Query: 8 PVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 ++G G YG VY+ VA+K+++ ++E A+++ ++ Sbjct: 30 MKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEV------EEFLKEAAVMKEIK--- 80 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLR 126 HPN+V+L+ VC RE ++ E + +L YL + + A + + Q Sbjct: 81 HPNLVQLLGVCT-----REPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISS 135 Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY--SYQMALTPVVVTLWYRAPE 184 +++L +HRDL N LV VK+ADFGL+R+ A + + APE Sbjct: 136 AMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPE 195 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 L + ++ D+W+ G + E+ + G + + + + P Sbjct: 196 SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCP---- 251 Query: 244 LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 E +L+ +NP R S Sbjct: 252 ----------------------EKVYELMRACWQWNPSDRPSFAEI 275 >4E93-A nrPDB Length = 377 Score = 203 bits (516), Expect = 9e-53, Method: Composition-based stats. Identities = 64/291 (21%), Positives = 115/291 (39%), Gaps = 45/291 (15%) Query: 8 PVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 +IG G +G V+ R VA+KS R L ++E +L++ + Sbjct: 118 LGEQIGRGNFGEVFSGRLRADNTLVAVKSCR----ETLPPDLKAKFLQEARILKQ---YS 170 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 HPN+VRL+ VC + + +V E V + L +T+ ++ G Sbjct: 171 HPNIVRLIGVCTQKQP-----IYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAG 225 Query: 128 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTP---VVVTLWYRAPE 184 +++L + C +HRDL N LVT +K++DFG++R + + V + + APE Sbjct: 226 MEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPE 285 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 L Y++ D+WS G + E F + S + LP + P Sbjct: 286 ALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP---- 341 Query: 244 LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI---SAFRALQ 291 ++ +L+ + + P +R + ++ LQ Sbjct: 342 ----------------------DAVFRLMEQCWAYEPGQRPSFSTIYQELQ 370 >3PFQ-A nrPDB Length = 674 Score = 203 bits (516), Expect = 9e-53, Method: Composition-based stats. Identities = 56/303 (18%), Positives = 107/303 (35%), Gaps = 45/303 (14%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 M + + + +G G++G V + + A+K ++ + V L Sbjct: 338 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 397 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKD 119 + P + +L T ++ V E+V DL ++ + Sbjct: 398 ----PGKPPFLTQLHSCFQTMD-----RLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVF 446 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-YSYQMALTPVVVTL 178 + GL FL + I++RDLK +N+++ S G +K+ADFG+ + + T Sbjct: 447 YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP 506 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y APE++ Y VD W+ G + EM + F G E + I + Sbjct: 507 DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME---------- 556 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISA-----FRALQHS 293 + M + + ++T +P KR+ +H+ Sbjct: 557 -----------------HNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHA 599 Query: 294 YLH 296 + Sbjct: 600 FFR 602 >2BRG-A nrPDB Length = 297 Score = 203 bits (516), Expect = 1e-52, Method: Composition-based stats. Identities = 74/300 (24%), Positives = 119/300 (39%), Gaps = 43/300 (14%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 ++ V +G GAYG V A + + VA+K V + P + +E+ + + L Sbjct: 7 EDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVD----CPENIKKEICINKML 62 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLMR 122 H NVV+ L E+ L ++ P G+P + Sbjct: 63 ---NHENVVKFYG-----HRREGNIQYLFLEYCSGGELFDRIE--PDIGMPEPDAQRFFH 112 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLA---RIYSYQMALTPVVVTLW 179 Q + G+ +LH I HRD+KPEN+L+ +K++DFGLA R + + L + TL Sbjct: 113 QLMAGVVYLHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLP 172 Query: 180 YRAPEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y APE+L + + A PVD+WS G + M + + DQ P D Sbjct: 173 YVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPW------DQ-----------PSDSC 215 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + + S LL ++L NP RI+ + + +K Sbjct: 216 QEYSDWKEKKTYLNPWKKIDSAP-------LALLHKILVENPSARITIPDIKKDRWYNKP 268 >3M42-A nrPDB Length = 299 Score = 202 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 66/306 (21%), Positives = 111/306 (36%), Gaps = 58/306 (18%) Query: 3 TSRYEPV-AEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 Y+ +G+G G V + + + ALK + REV L Sbjct: 16 IDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKML----------QDCPKARREVELHW 65 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDL 120 R A + P++VR++DV R+ + +V E +D L + + ++ Sbjct: 66 R--ASQCPHIVRIVDVYENLYAGRKC-LLIVMECLDGGELFSRIQDRGDQAFTEREASEI 122 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVT 177 M+ + +LH+ I HRD+KPEN+L TS +KL DFG A+ + Sbjct: 123 MKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETT----------- 171 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 Y DMWS+G I + P F N GL Sbjct: 172 ----------GEKYDKSCDMWSLGVIMYILLCGYPPFYSNH------------GLAISPG 209 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 + + + FP E+ E L+ +L P +R++ + H ++ + Sbjct: 210 MKTRIRMGQYEFPNPE-------WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQ 262 Query: 298 DEGNPE 303 P+ Sbjct: 263 STKVPQ 268 >2J0K-A nrPDB Length = 656 Score = 202 bits (515), Expect = 1e-52, Method: Composition-based stats. Identities = 61/293 (20%), Positives = 109/293 (37%), Gaps = 47/293 (16%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSG---HFVALKSVRVPNGGGGGGGLPISTVREVALL 60 R E IG G +G V++ VA+K+ + + ++E + Sbjct: 390 ERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCK----NCTSDSVREKFLQEALTM 445 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKD 119 R+ F+HP++V+L+ V E V ++ E +LR++L + L ++ Sbjct: 446 RQ---FDHPHIVKLIGVIT------ENPVWIIMELCTLGELRSFL-QVRKFSLDLASLIL 495 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV--T 177 Q L +L + VHRD+ N+LV++ VKL DFGL+R Sbjct: 496 YAYQLSTALAYLESKRFVHRDIAARNVLVSATDCVKLGDFGLSRYMEDSTYYKASKGKLP 555 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPED 236 + + APE + + + D+W G E+ F G D +G+I + LP Sbjct: 556 IKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPP 615 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 + P + L+ + ++P +R Sbjct: 616 NCP--------------------------PTLYSLMTKCWAYDPSRRPRFTEL 642 >6E2O-A nrPDB Length = 295 Score = 202 bits (514), Expect = 1e-52, Method: Composition-based stats. Identities = 75/293 (25%), Positives = 120/293 (40%), Gaps = 45/293 (15%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +G G YG VY RD + +A+K + E+AL + L+ H N Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEI-----PERDSRYSQPLHEEIALHKHLK---HKN 80 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGL--PAETIKDLMRQFLRGL 128 +V+ + + + + + E V + L ++ L +TI +Q L GL Sbjct: 81 IVQYLGSFSENGF-----IKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGL 135 Query: 129 DFLHANCIVHRDLKPENILVTS-GGTVKLADFGLARIYSYQMALT-PVVVTLWYRAPEVL 186 +LH N IVHRD+K +N+L+ + G +K++DFG ++ + T TL Y APE++ Sbjct: 136 KYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEII 195 Query: 187 LQST--YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244 + Y D+WS+GC EM KP F ++ Sbjct: 196 DKGPRGYGKAADIWSLGCTIIEMATGKPPFY-------------------------ELGE 230 Query: 245 PRGAFPPRGPRPVQSVVPE-MEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 P+ A G V +PE M +L+ +P KR A L +L Sbjct: 231 PQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLK 283 >3DKO-A nrPDB Length = 318 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 66/283 (23%), Positives = 113/283 (39%), Gaps = 26/283 (9%) Query: 7 EPVAEIGVGAYGTVYKARDPHSGHF---VALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 + IG G +G V R G VA+K+++V G + E +++ + Sbjct: 46 KIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKV----GYTEKQRRDFLCEASIMGQ- 100 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 F+HPNVV L V + V +V E ++ + + ++R Sbjct: 101 --FDHPNVVHLEGVVTRGKP-----VMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRG 153 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ----MALTPVVVTLW 179 G+ +L VHRDL NILV S K++DFGL+R+ T + + Sbjct: 154 IAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVR 213 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAE-MFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 + APE + + + D+WS G + E M + + S D + I + LP D Sbjct: 214 WTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDC 273 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPH 281 P + + ++ P+ E +L +M+ NP+ Sbjct: 274 PAGLH----QLMLDCWQKERAERPKF-EQIVGILDKMIR-NPN 310 >2R2P-A nrPDB Length = 295 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 61/282 (21%), Positives = 110/282 (39%), Gaps = 26/282 (9%) Query: 8 PVAEIGVGAYGTVYKARDPHSGHF---VALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 IG G +G V R G VA+K+++V G + E +++ + Sbjct: 26 IERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKV----GYTEKQRRDFLGEASIMGQ-- 79 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 F+HPN++ L V S+ V +V E+++ K + ++R Sbjct: 80 -FDHPNIIHLEGVVTKSKP-----VMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGI 133 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ----MALTPVVVTLWY 180 G+ +L VHRDL NIL+ S K++DFGL+R+ + + + Sbjct: 134 SAGMKYLSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRW 193 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 APE + + + D+WS G + E+ + + + D + + + LP D P Sbjct: 194 TAPEAIAFRKFTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCP 253 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPH 281 + + ++ P+ +E L L NP Sbjct: 254 AAL----YQLMLDCWQKERNSRPKFDEIVNMLDK--LIRNPA 289 >2XYN-A nrPDB Length = 292 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 59/298 (19%), Positives = 111/298 (37%), Gaps = 51/298 (17%) Query: 2 ATSRYEPVA-------EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTV 54 + ++E ++G G YG VY VA+K+++ + Sbjct: 23 SMDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEV------EEFL 76 Query: 55 REVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLP 113 +E A+++ ++ HPN+V+L+ VC E +V E++ +L YL + + Sbjct: 77 KEAAVMKEIK---HPNLVQLLGVCT-----LEPPFYIVTEYMPYGNLLDYLRECNREEVT 128 Query: 114 AETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY--SYQMAL 171 A + + Q +++L +HRDL N LV VK+ADFGL+R+ A Sbjct: 129 AVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAH 188 Query: 172 TPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLI 230 + + APE L +T++ D+W+ G + E+ + G + + Sbjct: 189 AGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGY 248 Query: 231 GLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFR 288 + + P +L+ ++P R S Sbjct: 249 RMEQPEGCP--------------------------PKVYELMRACWKWSPADRPSFAE 280 >5SYS-A nrPDB Length = 286 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 62/299 (20%), Positives = 114/299 (38%), Gaps = 50/299 (16%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 ++G G +G + + VA+K+++ G P + ++E ++++L H Sbjct: 25 KLGQGCFGECWMGTWNGT-TRVAIKTLK------PGTMSPEAFLQEAQVMKKLR---HEK 74 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 +V+L V + E + +V E++ L +L L + D+ Q G+ Sbjct: 75 LVQLYAVVS------EEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMA 128 Query: 130 FLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY--QMALTPVVVTLWYRAPEVLL 187 ++ VHRDL+ NILV K+ADFGLAR+ A + + APE L Sbjct: 129 YVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAAL 188 Query: 188 QSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPR 246 + D+WS G + E+ + + G + L ++ +P + P Sbjct: 189 YGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECP------- 241 Query: 247 GAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAF--RALQHSYLHKDEGNPE 303 ES L+ + +P +R + +A Y P+ Sbjct: 242 -------------------ESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFT--STEPQ 279 >4IAN-A nrPDB Length = 358 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 84/332 (25%), Positives = 141/332 (42%), Gaps = 45/332 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDP-HSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 RY G G + V +ARD + VA+K +R + + ++E+ L+ Sbjct: 29 DKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIR------NNELMQKTGLKELEFLK 82 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDK-APPPGLPAETIKDL 120 +L + + + + + + LVFE + +LR L K GL + ++ Sbjct: 83 KLNDADPDD--KFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSY 140 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTV-KLADFGLARIYSYQMALTPVVVTLW 179 +Q L L I+H D+KP+NILV T+ KL DFG A + +TP +V+ + Sbjct: 141 SQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVA-DNDITPYLVSRF 199 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPED--- 236 YRAPE+++ +Y +DMWSVGC E++ K LF G + L DL G P Sbjct: 200 YRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIR 259 Query: 237 -------DWPRDVSLPRGAFPPRGPRPVQSVVPEMEE----------------------- 266 + ++++ R +V+ + Sbjct: 260 KGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVH 319 Query: 267 SGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 LL ++L +P KRIS +ALQH+++ + Sbjct: 320 QLKDLLDQILMLDPAKRISINQALQHAFIQEK 351 >4KIK-B nrPDB Length = 677 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 81/286 (28%), Positives = 116/286 (40%), Gaps = 16/286 (5%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +E +G G +G V + + +G +A+K R + E+ ++RRL Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL----EIQIMRRL-- 74 Query: 66 FEHPNVVRLMDVCATSRTDREIKV-TLVFEHV-DQDLRTYLDK-APPPGLPAETIKDLMR 122 HPNVV DV + + L E+ DLR YL++ GL I L+ Sbjct: 75 -THPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLS 133 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTV---KLADFGLARIYSYQMALTPVVVTLW 179 L +LH N I+HRDLKPENI++ G K+ D G A+ T V TL Sbjct: 134 DIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQ 193 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 Y APE+L Q Y VD WS G + E F N + Q Sbjct: 194 YLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSE 253 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 + + P + SV+ E E QL ML ++P +R + Sbjct: 254 DLNGTVKFSSSLPYPNNLNSVLAERLEKWLQL---MLMWHPRQRGT 296 >6CCF-A nrPDB Length = 290 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 77/319 (24%), Positives = 124/319 (38%), Gaps = 52/319 (16%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPN------------------G 42 M ++Y+ +EIG GAYG V A + A+K + Sbjct: 2 MQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAA 61 Query: 43 GGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRT 102 GG + R + L+ +H NVV+L++V D + LVF+ + + Sbjct: 62 QGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDN---LYLVFDLLRKG--P 116 Query: 103 YLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLA 162 ++ E + +R + GL++LH IVHRD+KP N+L+ G VK+ADFG++ Sbjct: 117 VMEVPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVS 176 Query: 163 RIYS-YQMALTPVVVTLWYRAPEVLLQST---YATPVDMWSVGCIFAEMFRRKPLFCGNS 218 + L+ T + APE + S +D+W+ G K F + Sbjct: 177 NQFEGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDF 236 Query: 219 EADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTF 278 KI + + PE+ PE+ E L+L+ML Sbjct: 237 ILALHRKIKNEPVVFPEE-------------------------PEISEELKDLILKMLDK 271 Query: 279 NPHKRISAFRALQHSYLHK 297 NP RI H ++ K Sbjct: 272 NPETRIGVPDIKLHPWVTK 290 >3TKU-A nrPDB Length = 433 Score = 200 bits (510), Expect = 4e-52, Method: Composition-based stats. Identities = 68/304 (22%), Positives = 113/304 (37%), Gaps = 45/304 (14%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 +E + IG GA+G V + ++ A+K + R+V L Sbjct: 90 EDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDV-----L 144 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEH-VDQDLRTYLDKAPPPGLPAETIKDLMR 122 + + L E + LV ++ V DL T L K LP + + + Sbjct: 145 VNGDCQWITALHYAFQD-----ENHLYLVMDYYVGGDLLTLLSKFEDK-LPEDMARFYIG 198 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ--MALTPVVVTLWY 180 + + +D +H VHRD+KP+N+L+ G ++LADFG + + + V T Y Sbjct: 199 EMVLAIDSIHQLHYVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDY 258 Query: 181 RAPEVLL-----QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPE 235 +PE+L Y D WS+G EM + F S + GKI + Sbjct: 259 ISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN------- 311 Query: 236 DDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI---SAFRALQH 292 R FP S V ++ E L+ L + +R+ +H Sbjct: 312 -------HEERFQFP--------SHVTDVSEEAKDLIQR-LICSRERRLGQNGIEDFKKH 355 Query: 293 SYLH 296 ++ Sbjct: 356 AFFE 359 >2I0E-A nrPDB Length = 353 Score = 200 bits (510), Expect = 4e-52, Method: Composition-based stats. Identities = 53/259 (20%), Positives = 100/259 (38%), Gaps = 13/259 (5%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 M + + + +G G++G V + + A+K ++ + V L Sbjct: 17 MKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLAL 76 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKD 119 + P + +L T ++ V E+V DL ++ + Sbjct: 77 ----PGKPPFLTQLHSCFQTMD-----RLYFVMEYVNGGDLMYHIQQVGR--FKEPHAVF 125 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-YSYQMALTPVVVTL 178 + GL FL + I++RDLK +N+++ S G +K+ADFG+ + + T Sbjct: 126 YAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTP 185 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y APE++ Y VD W+ G + EM + F G E + I + P+ Sbjct: 186 DYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMS 245 Query: 239 PRDVSLPRGAFPPRGPRPV 257 V++ +G + + Sbjct: 246 KEAVAICKGLMTKHPGKRL 264 >4WUA-A nrPDB Length = 401 Score = 200 bits (510), Expect = 4e-52, Method: Composition-based stats. Identities = 95/373 (25%), Positives = 150/373 (40%), Gaps = 87/373 (23%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + RY + ++G G + TV+ + D FVA+K V+ + + E+ LL Sbjct: 38 LFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVK------SAEHYTETALDEIRLL 91 Query: 61 RRLEAFEHPN------VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPA 114 + + + PN VV+L+D S + + +VFE + L ++ K+ GLP Sbjct: 92 KSVRNSD-PNDPNREMVVQLLDDFKISGVNG-THICMVFEVLGHHLLKWIIKSNYQGLPL 149 Query: 115 ETIKDLMRQFLRGLDFLHANC-IVHRDLKPENILVTSGGT-------------------- 153 +K +++Q L+GLD+LH C I+H D+KPENIL++ Sbjct: 150 PCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPP 209 Query: 154 -----------------------------VKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 VK+AD G A T + T YR+ E Sbjct: 210 SGSAVSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVH--KHFTEDIQTRQYRSLE 267 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNS------EADQLGKIFDLIGLPPED-- 236 VL+ S Y TP D+WS C+ E+ LF +S + D + I +L+G P Sbjct: 268 VLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLI 327 Query: 237 ---DWPRDVSLPRG------AFPPRGPRPVQSVVPEMEESGA----QLLLEMLTFNPHKR 283 + ++ +G P G V E + A LL ML P KR Sbjct: 328 VAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKR 387 Query: 284 ISAFRALQHSYLH 296 +A L+H +L+ Sbjct: 388 ATAAECLRHPWLN 400 >3FME-A nrPDB Length = 290 Score = 200 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 64/304 (21%), Positives = 112/304 (36%), Gaps = 44/304 (14%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + EP+ E+G GAYG V K R SG +A+K +R L + Sbjct: 4 VKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDI----- 58 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKA--PPPGLPAETIK 118 + + P V RE V + E +D L + + +P + + Sbjct: 59 -SMRTVDCPFTVTFYGAL-----FREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILG 112 Query: 119 DLMRQFLRGLDFLHAN-CIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVT 177 + ++ L+ LH+ ++HRD+KP N+L+ + G VK+ DFG++ +A Sbjct: 113 KIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDDVAKDIDAGC 172 Query: 178 LWYRAPEVL----LQSTYATPVDMWSVGCIFAEMFRRKPLFCG-NSEADQLGKIFDLIGL 232 Y APE + Q Y+ D+WS+G E+ + + + QL ++ + Sbjct: 173 KPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVE---- 228 Query: 233 PPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQH 292 P P D + + L N +R + +QH Sbjct: 229 EPSPQLPAD---------------------KFSAEFVDFTSQCLKKNSKERPTYPELMQH 267 Query: 293 SYLH 296 + Sbjct: 268 PFFT 271 >3ALO-A nrPDB Length = 327 Score = 200 bits (508), Expect = 7e-52, Method: Composition-based stats. Identities = 70/296 (23%), Positives = 114/296 (38%), Gaps = 42/296 (14%) Query: 9 VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 + EIG GAYG+V K SG +A+K +R L + ++R + + Sbjct: 27 LGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLD---VVMR---SSDC 80 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQDL---RTYLDKAPPPGLPAETIKDLMRQFL 125 P +V+ RE + E + Y+ +P E + + + Sbjct: 81 PYIVQFYGAL-----FREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATV 135 Query: 126 RGLDFLHAN-CIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 + L+ L N I+HRD+KP NIL+ G +KL DFG++ +A T Y APE Sbjct: 136 KALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPE 195 Query: 185 VL----LQSTYATPVDMWSVGCIFAEMFRRKPLFC-GNSEADQLGKIFDLIGLPPEDDWP 239 + + Y D+WS+G E+ + + NS DQL ++ G PP+ Sbjct: 196 RIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVK--GDPPQLSNS 253 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 + E S + LT + KR L+H ++ Sbjct: 254 EE--------------------REFSPSFINFVNLCLTKDESKRPKYKELLKHPFI 289 >5H2U-A nrPDB Length = 267 Score = 200 bits (508), Expect = 9e-52, Method: Composition-based stats. Identities = 61/285 (21%), Positives = 109/285 (38%), Gaps = 43/285 (15%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 + ++G G +G V++ VA+K + N E+ +++L Sbjct: 6 EEFTLCRKLGSGYFGEVFEGLWK-DRVQVAIKVISRDNLLH-----QQMLQSEIQAMKKL 59 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMR 122 H +++ L V + V ++ E + L L + LP + D+ Sbjct: 60 R---HKHILALYAVVSVGDP-----VYIITELMAKGSLLELLRDSDEKVLPVSELLDIAW 111 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLW-YR 181 Q G+ +L + +HRDL NILV K+ DFGLAR+ + L+ + + Sbjct: 112 QVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWT 171 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 APE L + Y+T D+WS G + EMF + + G S + ++ +P + P Sbjct: 172 APEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECP- 230 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 S +L+L +P +R + Sbjct: 231 -------------------------PSVHKLMLTCWCRDPEQRPT 250 >5KKR-C nrPDB Length = 395 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 71/327 (21%), Positives = 127/327 (38%), Gaps = 46/327 (14%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + +E ++E+G G G V+K SG +A K + + + +RE+ +L Sbjct: 65 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE----IKPAIRNQIIRELQVL 120 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKD 119 + P +V + + ++++ EH+D L L KA +P + + Sbjct: 121 HECNS---PYIVGFYGAFYS-----DGEISICMEHMDGGSLDQVLKKAGR--IPEQILGK 170 Query: 120 LMRQFLRGLDFL-HANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTL 178 + ++GL +L + I+HRD+KP NILV S G +KL DFG++ MA V T Sbjct: 171 VSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTR 229 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI------------ 226 Y +PE L + Y+ D+WS+G EM + + Sbjct: 230 SYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETP 289 Query: 227 ---------FDLIGLP--PEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEM 275 G+ P + PP+ P V S+ + + Sbjct: 290 PRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSAVFSL------EFQDFVNKC 343 Query: 276 LTFNPHKRISAFRALQHSYLHKDEGNP 302 L NP +R + + H+++ + + Sbjct: 344 LIKNPAERADLKQLMVHAFIKRSDAEE 370 >6BXI-A nrPDB Length = 333 Score = 198 bits (504), Expect = 2e-51, Method: Composition-based stats. Identities = 70/311 (22%), Positives = 114/311 (36%), Gaps = 72/311 (23%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + +E + IG GA+G V + +GH A+K +R + I R++ Sbjct: 3 LGLEDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDI--- 59 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKD 119 L + VV++ ++ + L+ E + D+ T L L E + Sbjct: 60 --LVEADSLWVVKMFYSFQD-----KLNLYLIMEFLPGGDMMTLL--MKKDTLTEEETQF 110 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-------------- 165 + + + +D +H +HRD+KP+N+L+ S G VKL+DFGL Sbjct: 111 YIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNH 170 Query: 166 ----------------------SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCI 203 + + V T Y APEV +Q+ Y D WS+G I Sbjct: 171 SLPSDFTFQNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVI 230 Query: 204 FAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPE 263 EM P FC + + K+ + W + FPP P Sbjct: 231 MYEMLIGYPPFCSETPQETYKKVMN---------WKETL-----TFPPEVP--------- 267 Query: 264 MEESGAQLLLE 274 + E L+L Sbjct: 268 ISEKAKDLILR 278 >4LQP-A nrPDB Length = 508 Score = 198 bits (504), Expect = 2e-51, Method: Composition-based stats. Identities = 67/360 (18%), Positives = 113/360 (31%), Gaps = 103/360 (28%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 + V IG GA+G V + +G A+K++ + R+V L Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDV-----L 156 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMR 122 + P VV L ++ + L+ E + DL T L + + + M Sbjct: 157 AGSDSPWVVSLYYSFQDAQ-----YLYLIMEFLPGGDLMTMLIRW--QLFTEDVTRFYMA 209 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADF----------------------- 159 + + ++ +H +HR +KP+NIL+ G +KL+DF Sbjct: 210 ECILAIETIHKLGFIHRAIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDE 269 Query: 160 ---GLARIYSYQMALT------------------------------------PVVVTLWY 180 G+++ +Y T V T Y Sbjct: 270 ATNGISKPGTYNANTTDTANKRQTMVVDSISLTMSNRQQIQTWRKSRRLMAYSTVGTPDY 329 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 APE+ L Y D WS+G I E P FC + + KI + +P Sbjct: 330 IAPEIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQT---LQFPD 386 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI----SAFRALQHSYLH 296 D+ + L+ +LT +R+ A H + Sbjct: 387 DIHI--------------------SYEAEDLIRRLLTH-ADQRLGRHGGADEIKSHPFFR 425 >4AW2-A nrPDB Length = 437 Score = 198 bits (504), Expect = 2e-51, Method: Composition-based stats. Identities = 68/307 (22%), Positives = 112/307 (36%), Gaps = 45/307 (14%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 +E + IG GA+G V + ++ A+K + R+V L Sbjct: 74 EDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDV-----L 128 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEH-VDQDLRTYLDKAPPPGLPAETIKDLMR 122 + + L + LV ++ V DL T L K LP E + + Sbjct: 129 VNGDSKWITTLHYAFQDDNN-----LYLVMDYYVGGDLLTLLSKFEDR-LPEEMARFYLA 182 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY--SYQMALTPVVVTLWY 180 + + +D +H VHRD+KP+NIL+ G ++LADFG + + V T Y Sbjct: 183 EMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDY 242 Query: 181 RAPEVLL-----QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPE 235 +PE+L + Y D WS+G EM + F S + GKI + Sbjct: 243 ISPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMN------- 295 Query: 236 DDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI---SAFRALQH 292 R FP + V ++ E+ L+ L + R+ +H Sbjct: 296 -------HKERFQFP--------TQVTDVSENAKDLIRR-LICSREHRLGQNGIEDFKKH 339 Query: 293 SYLHKDE 299 + + Sbjct: 340 PFFSGID 346 >4UYA-A nrPDB Length = 340 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 76/303 (25%), Positives = 112/303 (36%), Gaps = 52/303 (17%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 +A R E IG G +G VY+A G VA+K+ R S RE L Sbjct: 23 VAFERLELKELIGAGGFGQVYRATW--QGQEVAVKAARQDPEQDAAAA-AESVRREARLF 79 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 L HPN++ L VC ++ + LV E +P + + Sbjct: 80 AMLR---HPNIIELRGVCL-----QQPHLCLVLEFARGGALN--RALAGRRIPPHVLVNW 129 Query: 121 MRQFLRGLDFLHANC---IVHRDLKPENILVTS--------GGTVKLADFGLARIYSYQM 169 Q RG+ +LH I+HRDLK NIL+ T+K+ DFGLAR + Sbjct: 130 AVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTT 189 Query: 170 ALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQ-LGKIFD 228 + + APEV+ S ++ D+WS G + E+ + + G G + Sbjct: 190 KMATA-GAYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVN 248 Query: 229 LIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFR 288 + LP P E A+L+ E +PH R S Sbjct: 249 KLTLPIPSTCP--------------------------EPFAKLMKECWQQDPHIRPSFAL 282 Query: 289 ALQ 291 L+ Sbjct: 283 ILE 285 >4AN9-A nrPDB Length = 301 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 69/304 (22%), Positives = 124/304 (40%), Gaps = 42/304 (13%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + +E ++E+G G G V+K SG +A K + + + +RE+ +L Sbjct: 6 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE----IKPAIRNQIIRELQVL 61 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKD 119 + P +V + + ++++ EH+D L L KA +P + + Sbjct: 62 HECNS---PYIVGFYGAFYS-----DGEISICMEHMDGGSLDQVLKKAGR--IPEQILGK 111 Query: 120 LMRQFLRGLDFL-HANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTL 178 + ++GL +L + I+HRD+KP NILV S G +KL DFG++ +MA V T Sbjct: 112 VSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDEMA-NEFVGTR 170 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y +PE L + Y+ D+WS+G EM + + + L I + P Sbjct: 171 SYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVN----EPPPKL 226 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 P V + + L NP +R + + H+++ + Sbjct: 227 PSAV---------------------FSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRS 265 Query: 299 EGNP 302 + Sbjct: 266 DAEE 269 >5VO2-A nrPDB Length = 300 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 63/292 (21%), Positives = 108/292 (36%), Gaps = 55/292 (18%) Query: 6 YEPVAEI---GVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 +E + ++ G GA G V+ R G VA+K VR ++ Sbjct: 11 FEEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD---------------IKH 53 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLM 121 L +HPN++ VC + ++ E L L P + + D Sbjct: 54 LRKLKHPNIITFKGVCTQA-----PCYCILMEFCAQGQLYEVLRAGRP--VTPSLLVDWS 106 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYR 181 G+++LH + I+HRDLK N+L+T VK++DFG ++ S + T+ + Sbjct: 107 MGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWM 166 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI-FDLIGLPPEDDWPR 240 APEV+ + VD+WS G + E+ + + + + + + + LP P Sbjct: 167 APEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPD 226 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQH 292 + LL + P R S + L H Sbjct: 227 GFKI--------------------------LLRQCWNSKPRNRPSFRQILLH 252 >1FVR-A nrPDB Length = 327 Score = 197 bits (502), Expect = 4e-51, Method: Composition-based stats. Identities = 66/298 (22%), Positives = 109/298 (36%), Gaps = 55/298 (18%) Query: 11 EIGVGAYGTVYKARDPHSGHFV--ALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 IG G +G V KAR G + A+K ++ E+ +L +L H Sbjct: 32 VIGEGNFGQVLKARIKKDGLRMDAAIKRMK----EYASKDDHRDFAGELEVLCKLG--HH 85 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAP--------------PPGLP 113 PN++ L+ C + L E+ +L +L K+ L Sbjct: 86 PNIINLLGACEH-----RGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLS 140 Query: 114 AETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTP 173 ++ + RG+D+L +HRDL NILV K+ADFGL+R + T Sbjct: 141 SQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTM 200 Query: 174 VVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGL 232 + + + A E L S Y T D+WS G + E+ +CG + A+ K+ L Sbjct: 201 GRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRL 260 Query: 233 PPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRAL 290 + ++ L+ + P++R S + L Sbjct: 261 EKPLNC--------------------------DDEVYDLMRQCWREKPYERPSFAQIL 292 >3ORP-A nrPDB Length = 311 Score = 197 bits (502), Expect = 4e-51, Method: Composition-based stats. Identities = 65/276 (23%), Positives = 111/276 (40%), Gaps = 13/276 (4%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + RYE +G G V+ ARD VA+K +R P +R + Sbjct: 11 SDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARD-----PSFYLRFRREAQN 65 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLM 121 A HP +V + D + +V E+VD LR + P + + +++ Sbjct: 66 AAALNHPAIVAVYDTGEAETPAGPLP-YIVMEYVDGVTLRDIVHTEGP--MTPKRAIEVI 122 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTP----VVVT 177 + L+F H N I+HRD+KP NI++++ VK+ DFG+AR + V+ T Sbjct: 123 ADACQALNFSHQNGIIHRDVKPANIMISATNAVKVMDFGIARAIADSGNSVTQTAAVIGT 182 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 Y +PE + D++S+GC+ E+ +P F G+S + +PP Sbjct: 183 AQYLSPEQARGDSVDARSDVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSAR 242 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLL 273 + + ++ E A L+ Sbjct: 243 HEGLSADLDAVVLKALAKNPENRYQTAAEMRADLVR 278 >3PPZ-A nrPDB Length = 309 Score = 197 bits (500), Expect = 6e-51, Method: Composition-based stats. Identities = 67/292 (22%), Positives = 114/292 (39%), Gaps = 46/292 (15%) Query: 8 PVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 +IG G++GTV++A G VA+K + + +REVA+++RL Sbjct: 41 IKEKIGAGSFGTVHRAEWH--GSDVAVKILMEQDFHAERVN---EFLREVAIMKRLR--- 92 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAP-PPGLPAETIKDLMRQFL 125 HPN+V M + +++V E++ L L K+ L + Sbjct: 93 HPNIVLFMGAVT-----QPPNLSIVTEYLSRGSLYRLLHKSGAREQLDERRRLSMAYDVA 147 Query: 126 RGLDFLHANC--IVHRDLKPENILVTSGGTVKLADFGLARIYSYQ-MALTPVVVTLWYRA 182 +G+++LH IVHRDLK N+LV TVK+ DFGL+R+ + ++ T + A Sbjct: 148 KGMNYLHNRNPPIVHRDLKSPNLLVDKKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMA 207 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 PEVL D++S G I E+ + + + A + + Sbjct: 208 PEVLRDEPSNEKSDVYSFGVILWELATLQQPWGNLNPAQVVAAVG--------------- 252 Query: 243 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI---SAFRALQ 291 + + A ++ T P KR + L+ Sbjct: 253 ----------FKCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATIMDLLR 294 >4LFI-A nrPDB Length = 374 Score = 197 bits (500), Expect = 7e-51, Method: Composition-based stats. Identities = 79/334 (23%), Positives = 142/334 (42%), Gaps = 48/334 (14%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSV---------------------RVPN 41 T YE ++G G Y V++ S + +K + +VP Sbjct: 39 TKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSNEKVPP 98 Query: 42 GGGGGGGLPISTVREVALLRRLEAF-------EHPNVVRLMDVCATSRTDREIKVTLVFE 94 T ++ +L+ + + H N++ L D+ + LVFE Sbjct: 99 TTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPA---LVFE 155 Query: 95 HVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTS-GGT 153 +VD L P L I+ M + L+ LD+ H+ I+HRD+KP N+++ Sbjct: 156 YVDNVDFRIL----YPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKNKK 211 Query: 154 VKLADFGLARIYSYQMALTPVVVTLWYRAPEVL-LQSTYATPVDMWSVGCIFAEM-FRRK 211 ++L D+GLA Y M V + +++ PE+L Y +D+WS G + A M F+R+ Sbjct: 212 LRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFKRE 271 Query: 212 PLFCGNSEADQLGKIFDLIGLPPEDDW--PRDVSLPRGAFPPRG--PRPVQSVVPE---- 263 P F G S DQL KI ++G + + +++LPR + +P + + Sbjct: 272 PFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGNKH 331 Query: 264 --MEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 + L+ +L ++ +R++A A+ H + Sbjct: 332 LSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWF 365 >4OTD-A nrPDB Length = 341 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 68/303 (22%), Positives = 116/303 (38%), Gaps = 44/303 (14%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + ++ +A +G G +G V + SG A+K+++ + + E +L Sbjct: 9 LTLEDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVESLMC--EKRIL 66 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEH-VDQDLRTYLDKAPPPGLPAETIKD 119 + + HP +V L T V V E+ DL ++ Sbjct: 67 AAVTSAGHPFLVNLFGCFQTPE-----HVCFVMEYSAGGDLMLHIHS---DVFSEPRAIF 118 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI-YSYQMALTPVVVTL 178 + GL FLH + IV+RDLK +N+L+ + G VK+ADFGL + Y + T Sbjct: 119 YSACVVLGLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTP 178 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 + APEVL ++Y VD W +G + EM + F G+ E + I + Sbjct: 179 EFLAPEVLTDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVN---------- 228 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-----SAFRALQHS 293 +V PR + ++ +L NP +R+ A + Sbjct: 229 -DEVRYPR----------------FLSAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQP 271 Query: 294 YLH 296 + Sbjct: 272 FFR 274 >3EQC-A nrPDB Length = 360 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 71/327 (21%), Positives = 128/327 (39%), Gaps = 46/327 (14%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + +E ++E+G G G V+K SG +A K + + + +RE+ +L Sbjct: 30 LKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLE----IKPAIRNQIIRELQVL 85 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKD 119 + P +V + + ++++ EH+D L L KA +P + + Sbjct: 86 HECNS---PYIVGFYGAFYS-----DGEISICMEHMDGGSLDQVLKKAGR--IPEQILGK 135 Query: 120 LMRQFLRGLDFL-HANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTL 178 + ++GL +L + I+HRD+KP NILV S G +KL DFG++ MA V T Sbjct: 136 VSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTR 194 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI------------ 226 Y +PE L + Y+ D+WS+G EM + + Sbjct: 195 SYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETP 254 Query: 227 ---------FDLIGLP--PEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEM 275 + G+ P + PP+ P V S+ + + Sbjct: 255 PRPRTPGRPLNKFGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSL------EFQDFVNKC 308 Query: 276 LTFNPHKRISAFRALQHSYLHKDEGNP 302 L NP +R + + H+++ + + Sbjct: 309 LIKNPAERADLKQLMVHAFIKRSDAEE 335 >5X5O-A nrPDB Length = 310 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 61/281 (21%), Positives = 107/281 (38%), Gaps = 51/281 (18%) Query: 13 GVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVV 72 G G++G+VY+A+ VA+K + + +E +L L H N++ Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKKL-------------LKIEKEAEILSVLS---HRNII 67 Query: 73 RLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFL 131 + V +V E+ L Y++ + + I +G+ +L Sbjct: 68 QFYGVILEPPNYG-----IVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYL 122 Query: 132 HAN---CIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQ 188 H ++HRDLK N+++ + G +K+ DFG +R +++ + +V T + APEV+ Sbjct: 123 HMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHM-SLVGTFPWMAPEVIQS 181 Query: 189 STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGA 248 + D +S G + EM R+ F G W R Sbjct: 182 LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQV--------------AWLVVEKNERLT 227 Query: 249 FPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 P PR S A+LL + + KR S + Sbjct: 228 IPSSCPR-----------SFAELLHQCWEADAKKRPSFKQI 257 >4UY9-A nrPDB Length = 323 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 75/296 (25%), Positives = 115/296 (38%), Gaps = 54/296 (18%) Query: 8 PVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 IG+G +G VY+A G VA+K+ R + + +E L L+ Sbjct: 13 LEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTI-ENVRQEAKLFAMLK--- 66 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLMRQFLR 126 HPN++ L VC +E + LV E L L +P + + + Q R Sbjct: 67 HPNIIALRGVCL-----KEPNLCLVMEFARGGPLNRVLS---GKRIPPDILVNWAVQIAR 118 Query: 127 GLDFLHANCI---VHRDLKPENILVT--------SGGTVKLADFGLARIYSYQMALTPVV 175 G+++LH I +HRDLK NIL+ S +K+ DFGLAR + + Sbjct: 119 GMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM-SAA 177 Query: 176 VTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQ-LGKIFDLIGLPP 234 T + APEV+ S ++ D+WS G + E+ + F G G + + LP Sbjct: 178 GTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPI 237 Query: 235 EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRAL 290 P E A+L+ + +PH R S L Sbjct: 238 PSTCP--------------------------EPFAKLMEDCWNPDPHSRPSFTNIL 267 >4YHJ-A nrPDB Length = 584 Score = 195 bits (495), Expect = 2e-50, Method: Composition-based stats. Identities = 63/298 (21%), Positives = 102/298 (34%), Gaps = 39/298 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 + +G G +G V + +G A ++ + E +L ++++ Sbjct: 187 FRHYRVLGKGGFGEVCACQVRATGKMYA--CKKLQKKRIKKRKGEAMALNEKRILEKVQS 244 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQF 124 VV L T + LV + DL+ ++ PG + + Sbjct: 245 ---RFVVSLAYAYETKDA-----LCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAEL 296 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 GL+ L IV+RDLKPENIL+ G ++++D GLA + V T+ Y APE Sbjct: 297 CCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPE 356 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244 V+ Y D W +GC+ EM + F + Sbjct: 357 VVNNEKYTFSPDWWGLGCLIYEMIQGHSPFK-----------------------KYKEKV 393 Query: 245 PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-----SAFRALQHSYLHK 297 R + + E + +LT NP KR+ A QH Sbjct: 394 KWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKD 451 >5TQX-A nrPDB Length = 655 Score = 194 bits (494), Expect = 3e-50, Method: Composition-based stats. Identities = 75/283 (26%), Positives = 112/283 (39%), Gaps = 15/283 (5%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +E +G G +G V + +A+KS R+ E+ ++++L Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCH----EIQIMKKL-- 63 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDK-APPPGLPAETIKDLMRQ 123 H NVV+ DV L E+ DLR L+K GL I L+ Sbjct: 64 -NHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSD 122 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTS-GGTV--KLADFGLARIYSYQMALTPVVVTLWY 180 G+ +LH N I+HRDLKPENI++ GG + K+ D G A+ T V TL Y Sbjct: 123 IGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQY 182 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 APE+ Y VD WS G + E F + + + Sbjct: 183 LAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEE 242 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKR 283 R + P + S++ E E+ QL ML ++P +R Sbjct: 243 MSGEVRFSSHLPQPNSLCSLIVEPMENWLQL---MLNWDPQQR 282 >4PDO-A nrPDB Length = 299 Score = 194 bits (494), Expect = 3e-50, Method: Composition-based stats. Identities = 57/242 (23%), Positives = 100/242 (41%), Gaps = 21/242 (8%) Query: 10 AEIGVGAYGTVYKARDP-HSGHF---VALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 IG G +G VYK SG VA+K+++ G + + E ++ + Sbjct: 40 KVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLK----AGYTEKQRVDFLGEAGIMGQ--- 92 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 F H N++RL V + + + ++ E+++ + + ++R Sbjct: 93 FSHHNIIRLEGVISKYKP-----MMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIA 147 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALT----PVVVTLWYR 181 G+ +L VHRDL NILV S K++DFGL+R+ T + + + Sbjct: 148 AGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWT 207 Query: 182 APEVLLQSTYATPVDMWSVGCIFAE-MFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 APE + + + D+WS G + E M + + S + + I D LP D P Sbjct: 208 APEAISYRKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPS 267 Query: 241 DV 242 + Sbjct: 268 AI 269 >3V5Q-A nrPDB Length = 297 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 64/306 (20%), Positives = 109/306 (35%), Gaps = 63/306 (20%) Query: 8 PVAEIGVGAYGTVYKARD-----PHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 E+G GA+G V+ A VA+K+++ P RE LL Sbjct: 19 LKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARK-----DFQREAELLTN 73 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLD--------------KA 107 L +H ++V+ VC + +VFE++ DL +L + Sbjct: 74 L---QHEHIVKFYGVCGDGDP-----LIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQ 125 Query: 108 PPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-- 165 L + + Q G+ +L + VHRDL N LV + VK+ DFG++R Sbjct: 126 AKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYS 185 Query: 166 -SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQL 223 Y ++ + + PE ++ + T D+WS G I E+F K + S + + Sbjct: 186 TDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI 245 Query: 224 GKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKR 283 I L P++V ++L P +R Sbjct: 246 ECITQGRVLERPRVCPKEVY--------------------------DVMLGCWQREPQQR 279 Query: 284 ISAFRA 289 ++ Sbjct: 280 LNIKEI 285 >2VD5-A nrPDB Length = 412 Score = 193 bits (492), Expect = 5e-50, Method: Composition-based stats. Identities = 73/308 (23%), Positives = 117/308 (37%), Gaps = 47/308 (15%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + +E + IG GA+ V + +G A+K + + G R+V Sbjct: 58 LQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDV--- 114 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEH-VDQDLRTYLDKAPPPGLPAETIKD 119 L + + +L E + LV E+ V DL T L K +PAE + Sbjct: 115 --LVNGDRRWITQLHFAFQD-----ENYLYLVMEYYVGGDLLTLLSKF-GERIPAEMARF 166 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPV--VVT 177 + + + +D +H VHRD+KP+NIL+ G ++LADFG + + V T Sbjct: 167 YLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLRADGTVRSLVAVGT 226 Query: 178 LWYRAPEVLL-------QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLI 230 Y +PE+L +Y D W++G EMF + F +S A+ GKI Sbjct: 227 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIV--- 283 Query: 231 GLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI---SAF 287 + +SLP V + E + +L P R+ A Sbjct: 284 ------HYKEHLSLPL-------------VDEGVPEEARDFIQRLLCP-PETRLGRGGAG 323 Query: 288 RALQHSYL 295 H + Sbjct: 324 DFRTHPFF 331 >6DBN-A nrPDB Length = 316 Score = 193 bits (492), Expect = 5e-50, Method: Composition-based stats. Identities = 74/292 (25%), Positives = 121/292 (41%), Gaps = 32/292 (10%) Query: 4 SRY-EPVAEIGVGAYGTVYKAR----DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVA 58 R+ + + ++G G +G V R ++G VA+KS++ +GG L +E+ Sbjct: 34 KRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLK----KEIE 89 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETI 117 +LR L H N+V+ +C D + L+ E + L+ YL K + + Sbjct: 90 ILRNLY---HENIVKYKGICTE---DGGNGIKLIMEFLPSGSLKEYLPKNKNK-INLKQQ 142 Query: 118 KDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVV-- 175 Q +G+D+L + VHRDL N+LV S VK+ DFGL + V Sbjct: 143 LKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDD 202 Query: 176 --VTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 233 +++ APE L+QS + D+WS G E+ +S++ + +IG P Sbjct: 203 RDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLT-----YCDSDSSPMALFLKMIG-P 256 Query: 234 PEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 + R P P P + QL+ + F P R S Sbjct: 257 THGQMTVTRLVNTLKEGKRLPCP-----PNCPDEVYQLMRKCWEFQPSNRTS 303 >3A4O-X nrPDB Length = 286 Score = 193 bits (492), Expect = 5e-50, Method: Composition-based stats. Identities = 56/240 (23%), Positives = 104/240 (43%), Gaps = 19/240 (7%) Query: 7 EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF 66 + V +G G +G V+ +S VA+K+++ G + + E L++ L Sbjct: 16 KLVKRLGAGQFGEVWMGYYNNS-TKVAVKTLK------PGTMSVQAFLEEANLMKTL--- 65 Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 +H +VRL V RE + ++ E++ L +L + + D Q Sbjct: 66 QHDKLVRLYAVVT-----REEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIA 120 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY--QMALTPVVVTLWYRAP 183 G+ ++ +HRDL+ N+LV+ K+ADFGLAR+ A + + AP Sbjct: 121 EGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAP 180 Query: 184 EVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 E + + D+WS G + E+ K + G + AD + + +P ++ P ++ Sbjct: 181 EAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDEL 240 >3DTC-A nrPDB Length = 271 Score = 193 bits (492), Expect = 6e-50, Method: Composition-based stats. Identities = 74/296 (25%), Positives = 114/296 (38%), Gaps = 54/296 (18%) Query: 8 PVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 IG+G +G VY+A G VA+K+ R + + +E L L+ Sbjct: 11 LEEIIGIGGFGKVYRAFWI--GDEVAVKAARHDPDEDISQTI-ENVRQEAKLFAMLK--- 64 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLMRQFLR 126 HPN++ L VC +E + LV E L L +P + + + Q R Sbjct: 65 HPNIIALRGVCL-----KEPNLCLVMEFARGGPLNRVLS---GKRIPPDILVNWAVQIAR 116 Query: 127 GLDFLHANCI---VHRDLKPENILVT--------SGGTVKLADFGLARIYSYQMALTPVV 175 G+++LH I +HRDLK NIL+ S +K+ DFGLAR + + Sbjct: 117 GMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKM-SAA 175 Query: 176 VTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQ-LGKIFDLIGLPP 234 + APEV+ S ++ D+WS G + E+ + F G G + + LP Sbjct: 176 GAYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPI 235 Query: 235 EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRAL 290 P E A+L+ + +PH R S L Sbjct: 236 PSTCP--------------------------EPFAKLMEDCWNPDPHSRPSFTNIL 265 >2A1A-B nrPDB Length = 284 Score = 193 bits (491), Expect = 8e-50, Method: Composition-based stats. Identities = 65/299 (21%), Positives = 109/299 (36%), Gaps = 55/299 (18%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 ++ + IG G +G V+KA+ G +K V+ N REV L +L Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVKYNN---------EKAEREVKALAKL- 61 Query: 65 AFEHPNVVRLMDVCATSRTDREIK-----------VTLVFEHVD-QDLRTYLDKAPPPGL 112 +H N+V D E + + E D L +++K L Sbjct: 62 --DHVNIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDKGTLEQWIEKRRGEKL 119 Query: 113 PAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALT 172 +L Q +G+D++H+ +++RDLKP NI + VK+ DFGL T Sbjct: 120 DKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFLVDTKQVKIGDFGLVTSLKNDGKRT 179 Query: 173 PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGL 232 TL Y +PE + Y VD++++G I AE+ Sbjct: 180 RSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL------------------------ 215 Query: 233 PPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 D + F + + ++ LL ++L+ P R + L+ Sbjct: 216 -----HVCDTAFETSKFFTDLRDGI--ISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 267 >3LLT-A nrPDB Length = 360 Score = 193 bits (490), Expect = 9e-50, Method: Composition-based stats. Identities = 70/342 (20%), Positives = 121/342 (35%), Gaps = 59/342 (17%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + + + + ++G G +G V + + + A+K VR + ++++ Sbjct: 32 LLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIKKYTRSAKIEADILKKIQND 91 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 V+ + L+FE + L + + G E IK Sbjct: 92 DINNNNI----VKYHGKFM-----YYDHMCLIFEPLGPSLYEIITRNNYNGFHIEDIKLY 142 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGG-------------------------TVK 155 + L+ L++L + H DLKPENIL+ +K Sbjct: 143 CIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIK 202 Query: 156 LADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFC 215 L DFG A S ++ T YRAPEV+L + DMWS GC+ AE++ LF Sbjct: 203 LIDFGCATFKSDYH--GSIINTRQYRAPEVILNLGWDVSSDMWSFGCVLAELYTGSLLFR 260 Query: 216 GNSEADQLGKIFDLIGLPPEDD---------------------WPRDVSLPRGAFPPRGP 254 + + L + +I P++ WP + S + Sbjct: 261 THEHMEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIKHVKKC 320 Query: 255 RPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 P+ ++ E L +L +P R S L+H +L Sbjct: 321 LPLYKIIK--HELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >4XCU-A nrPDB Length = 300 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 63/305 (20%), Positives = 109/305 (35%), Gaps = 54/305 (17%) Query: 4 SRYEPVAEIGVGAYGTVYKAR-------DPHSGHFVALKSVRVPNGGGGGGGLPISTVRE 56 R +G G +G V +A P VA+K ++ V E Sbjct: 17 DRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLK----DNASDKDLADLVSE 72 Query: 57 VALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPA- 114 + +++ + H N++ L+ VC +E + ++ E +LR +L PPG Sbjct: 73 MEVMKLIG--RHKNIINLLGVCT-----QEGPLYVIVECAAKGNLREFLRARRPPGSSEG 125 Query: 115 ----ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR---IYSY 167 + Q RG+ +L + +HRDL N+LVT +K+ADFGLAR Y Sbjct: 126 PLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDY 185 Query: 168 QMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKI 226 + + + + APE L Y D+WS G + E+F + G + + Sbjct: 186 YKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLL 245 Query: 227 FDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISA 286 + + P L+ E P +R + Sbjct: 246 REGHRMDRPPHCP--------------------------PELYGLMRECWHAAPSQRPTF 279 Query: 287 FRALQ 291 + ++ Sbjct: 280 KQLVE 284 >4XLV-A nrPDB Length = 328 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 76/331 (22%), Positives = 124/331 (37%), Gaps = 68/331 (20%) Query: 1 MATSRYEPVAEIGVGAYGTVYK--ARDPHSGH---FVALKSVRVPNGGGGGGGLPISTVR 55 ++ + + E+G G++G VY+ ARD G VA+K+V I + Sbjct: 36 VSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN----ESASLRERIEFLN 91 Query: 56 EVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPP----- 109 E ++++ F +VVRL+ V + + +V E + DL++YL P Sbjct: 92 EASVMK---GFTCHHVVRLLGVVSKGQPT-----LVVMELMAHGDLKSYLRSLRPEAENN 143 Query: 110 ---PGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IY 165 P + + + + G+ +L+A VHRDL N +V TVK+ DFG+ R IY Sbjct: 144 PGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIY 203 Query: 166 SYQMALTPVVV--TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQ 222 + + APE L + T DMWS G + E+ + + G S Sbjct: 204 ETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQV 263 Query: 223 LGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHK 282 L + D L D+ P E L+ FNP+ Sbjct: 264 LKFVMDGGYLDQPDNCP--------------------------ERVTDLMRMCWQFNPNM 297 Query: 283 RISAFRALQ------HS------YLHKDEGN 301 R + + H + H +E Sbjct: 298 RPTFLEIVNLLKDDLHPSFPEVSFFHSEENK 328 >4EQM-A nrPDB Length = 294 Score = 193 bits (490), Expect = 1e-49, Method: Composition-based stats. Identities = 71/275 (25%), Positives = 115/275 (41%), Gaps = 16/275 (5%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + RY+ V ++G G TVY A D VA+K++ +P REV Sbjct: 8 IINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETL--KRFEREVHNS 65 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKD 119 +L H N+V ++DV + + LV E+++ L Y++ P L +T + Sbjct: 66 SQLS---HQNIVSMIDV-----DEEDDCYYLVMEYIEGPTLSEYIESHGP--LSVDTAIN 115 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ--MALTPVVVT 177 Q L G+ H IVHRD+KP+NIL+ S T+K+ DFG+A+ S V+ T Sbjct: 116 FTNQILDGIKHAHDMRIVHRDIKPQNILIDSNKTLKIFDFGIAKALSETSLTQTNHVLGT 175 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQ-LGKIFDLIGLPPED 236 + Y +PE D++S+G + EM +P F G + + I D + D Sbjct: 176 VQYFSPEQAKGEATDECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTD 235 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQL 271 + + ++E L Sbjct: 236 VRKDIPQSLSNVILRATEKDKANRYKTIQEMKDDL 270 >4OLI-A nrPDB Length = 645 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 64/293 (21%), Positives = 112/293 (38%), Gaps = 36/293 (12%) Query: 4 SRY-EPVAEIGVGAYGTV----YKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVA 58 RY + + ++G G +G V Y + +G VA+K+++ G G +E+ Sbjct: 352 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSG----WKQEID 407 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETI 117 +LR L H ++++ C E + LV E+V LR YL + + + Sbjct: 408 ILRTLY---HEHIIKYKGCCED---QGEKSLQLVMEYVPLGSLRDYLPRH---SIGLAQL 458 Query: 118 KDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI----YSYQMALTP 173 +Q G+ +LH+ +HR+L N+L+ + VK+ DFGLA+ + Y Sbjct: 459 LLFAQQICEGMAYLHSQHYIHRNLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVRED 518 Query: 174 VVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 233 +++ APE L + + D+WS G E+ +S K +LIG+ Sbjct: 519 GDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHC-----DSSQSPPTKFLELIGIA 573 Query: 234 P-EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 + R L P L+ R + Sbjct: 574 QGQMTVLRLTELLERGERLPRPDKCPC-------EVYHLMKNCWETEASFRPT 619 Score = 91.5 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 49/279 (17%), Positives = 90/279 (32%), Gaps = 54/279 (19%) Query: 23 ARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSR 82 RD V LK + + +++ + H ++ + VC Sbjct: 88 GRDRGQELRVVLKVLDPSHHDIALAFYETASL--------MSQVSHTHLAFVHGVCVRGP 139 Query: 83 TDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLK 142 + +V E+V+ + +P + +Q L +L +VH ++ Sbjct: 140 EN-----IMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVC 194 Query: 143 PENILVTSGGT-------VKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQS--TYAT 193 NIL+ G +KL+D G+ + + + APE L + +T Sbjct: 195 GRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP---WLAPECLPGGANSLST 251 Query: 194 PVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPR 252 +D W G E+ F + S ++ E + R LP + P Sbjct: 252 AMDKWGFGATLLEICFDGEAPLQSRSPSE------------KEHFYQRQHRLPEPSCPQ- 298 Query: 253 GPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 A L + LT+ P +R S L+ Sbjct: 299 ---------------LATLTSQCLTYEPTQRPSFRTILR 322 >6GQK-A nrPDB Length = 328 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 62/312 (19%), Positives = 106/312 (33%), Gaps = 60/312 (19%) Query: 4 SRYEPVAEIGVGAYGTVYKA-----RDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVA 58 +R +G GA+G V +A + VA+K ++ + + E+ Sbjct: 41 NRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLK----PSAHSTEREALMSELK 96 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPG------ 111 +L L H N+V L+ C ++ E+ DL +L + Sbjct: 97 VLSYLG--NHENIVNLLGACTHGGPT-----LVITEYCCYGDLLNFLRRKRDEFVPYKVA 149 Query: 112 --------LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR 163 L E + Q +G+ FL + +HRDL NIL+T G K+ DFGLAR Sbjct: 150 PEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGNITKICDFGLAR 209 Query: 164 IY---SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSE 219 S + + + + APE + S Y D+WS G E+F + G Sbjct: 210 DIKNDSNYVDKGNARLPVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMPV 269 Query: 220 ADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFN 279 + K+ ++ ++ + Sbjct: 270 DSKFYKMIKEGFRMSSPEY-------------------------APAEMYDIMKTCWDAD 304 Query: 280 PHKRISAFRALQ 291 P KR + + +Q Sbjct: 305 PDKRPTFKQIVQ 316 >3KUL-B nrPDB Length = 325 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 63/304 (20%), Positives = 112/304 (36%), Gaps = 52/304 (17%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHF---VALKSVRVPNGGGGGGGLPISTVREV 57 + SR IG G G V R G VA+K+++ G + E Sbjct: 46 IEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIKALK----AGYTERQRRDFLSEA 101 Query: 58 ALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETI 117 +++ + F+HPN++RL V R +V E+++ + + Sbjct: 102 SIMGQ---FDHPNIIRLEGVVTRGRLA-----MIVTEYMENGSLDTFLRTHDGQFTIMQL 153 Query: 118 KDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ----MALTP 173 ++R G+ +L VHRDL N+LV S K++DFGL+R+ T Sbjct: 154 VGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNLVCKVSDFGLSRVLEDDPDAAYTTTG 213 Query: 174 VVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGL 232 + + + APE + T+++ D+WS G + E+ + + + D + + + L Sbjct: 214 GKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNRDVISSVEEGYRL 273 Query: 233 PPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI------SA 286 P P + QL+L+ + +R S Sbjct: 274 PAPMGCPHALH--------------------------QLMLDCWHKDRAQRPRFSQIVSV 307 Query: 287 FRAL 290 AL Sbjct: 308 LDAL 311 >1LUF-A nrPDB Length = 343 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 77/323 (23%), Positives = 121/323 (37%), Gaps = 73/323 (22%) Query: 4 SRYEPVAEIGVGAYGTVYKARDP-----HSGHFVALKSVRVPNGGGGGGGLPISTVREVA 58 + E V +IG GA+G V++AR P VA+K ++ + RE A Sbjct: 47 NNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLK----EEASADMQADFQREAA 102 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKA---------- 107 L+ F++PN+V+L+ VCA + + L+FE++ DL +L Sbjct: 103 LMAE---FDNPNIVKLLGVCAVGKP-----MCLLFEYMAYGDLNEFLRSMSPHTVCSLSH 154 Query: 108 ------------PPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVK 155 PP L + RQ G+ +L VHRDL N LV VK Sbjct: 155 SDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVK 214 Query: 156 LADFGLARIY---SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RK 211 +ADFGL+R Y A + + + PE + + Y T D+W+ G + E+F Sbjct: 215 IADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGL 274 Query: 212 PLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQL 271 + G + + + + D L ++ P L Sbjct: 275 QPYYGMAHEEVIYYVRDGNILACPENCPL--------------------------ELYNL 308 Query: 272 LLEMLTFNPHKRI---SAFRALQ 291 + + P R S R LQ Sbjct: 309 MRLCWSKLPADRPSFCSIHRILQ 331 >3C51-A nrPDB Length = 543 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 61/306 (19%), Positives = 100/306 (32%), Gaps = 42/306 (13%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 M + +G G +G V+ + +G A K + G +++ Sbjct: 182 MGEDWFLDFRVLGRGGFGEVFACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKI--- 238 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLD--KAPPPGLPAETI 117 L +V L T + + LV + D+R ++ PG Sbjct: 239 --LAKVHSRFIVSLAYAFET-----KTDLCLVMTIMNGGDIRYHIYNVDEDNPGFQEPRA 291 Query: 118 KDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALT-PVVV 176 Q + GL+ LH I++RDLKPEN+L+ G V+++D GLA T Sbjct: 292 IFYTAQIVSGLEHLHQRNIIYRDLKPENVLLDDDGNVRISDLGLAVELKAGQTKTKGYAG 351 Query: 177 TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPED 236 T + APE+LL Y VD +++G EM + F E Sbjct: 352 TPGFMAPELLLGEEYDFSVDYFALGVTLYEMIAARGPFRARGE----------------- 394 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-----SAFRALQ 291 + R + + + +L +P KR+ S Sbjct: 395 ------KVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQKDPEKRLGFRDGSCDGLRT 448 Query: 292 HSYLHK 297 H Sbjct: 449 HPLFRD 454 >3QGY-A nrPDB Length = 286 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 62/266 (23%), Positives = 106/266 (39%), Gaps = 22/266 (8%) Query: 9 VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 V EIG G +G V+ + VA+K+++ G + E ++ +L H Sbjct: 32 VQEIGSGQFGLVHLGYWLN-KDKVAIKTIK------EGSMSEDDFIEEAEVMMKLS---H 81 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 P +V+L VC + + LVFE ++ + + AET+ + G+ Sbjct: 82 PKLVQLYGVCL-----EQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGM 136 Query: 129 DFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY--SYQMALTPVVVTLWYRAPEVL 186 +L C++HRDL N LV +K++DFG+ R + T + + +PEV Sbjct: 137 AYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVF 196 Query: 187 LQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP 245 S Y++ D+WS G + E+F K + S ++ + + I PR S Sbjct: 197 SFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSE----VVEDISTGFRLYKPRLASTH 252 Query: 246 RGAFPPRGPRPVQSVVPEMEESGAQL 271 + P QL Sbjct: 253 VYQIMNHCWKERPEDRPAFSRLLRQL 278 >3QA8-A nrPDB Length = 676 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 66/215 (30%), Positives = 95/215 (44%), Gaps = 13/215 (6%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +E +G G +G V + +G VA+K R + E+ ++++L Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPKNRERWCL----EIQIMKKL-- 69 Query: 66 FEHPNVVRLMDVCATSRTDREIKV-TLVFEHVDQ-DLRTYLDK-APPPGLPAETIKDLMR 122 HPNVV +V + + L E+ + DLR YL++ GL I+ L+ Sbjct: 70 -NHPNVVSAREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLS 128 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTV---KLADFGLARIYSYQMALTPVVVTLW 179 L +LH N I+HRDLKPENI++ G K+ D G A+ T V TL Sbjct: 129 DISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQ 188 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLF 214 Y APE+L Q Y VD WS G + E F Sbjct: 189 YLAPELLEQKKYTVTVDYWSFGTLAFECITGFRPF 223 >3TT0-A nrPDB Length = 382 Score = 191 bits (485), Expect = 3e-49, Method: Composition-based stats. Identities = 61/314 (19%), Positives = 118/314 (37%), Gaps = 63/314 (20%) Query: 4 SRYEPVAEIGVGAYGTVYKA------RDPHSGH-FVALKSVRVPNGGGGGGGLPISTVRE 56 R +G GA+G V A +D + VA+K ++ + E Sbjct: 69 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLK----SDATEKDLSDLISE 124 Query: 57 VALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGL--- 112 + +++ + +H N++ L+ C ++ + ++ E+ +LR YL PPGL Sbjct: 125 MEMMKMIG--KHKNIINLLGACT-----QDGPLYVIVEYASKGNLREYLQARRPPGLEYS 177 Query: 113 -----------PAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGL 161 ++ + Q RG+++L + +HRDL N+LVT +K+ADFGL Sbjct: 178 YNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGL 237 Query: 162 AR---IYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGN 217 AR Y T + + + APE L Y D+WS G + E+F + G Sbjct: 238 ARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV 297 Query: 218 SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLT 277 + + + + + ++ + + + Sbjct: 298 PVEELFKLLKEGHRMDKPSNCTNELYMM--------------------------MRDCWH 331 Query: 278 FNPHKRISAFRALQ 291 P +R + + ++ Sbjct: 332 AVPSQRPTFKQLVE 345 >3DLS-A nrPDB Length = 335 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 60/297 (20%), Positives = 110/297 (37%), Gaps = 39/297 (13%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + +Y ++ +G GA+G V+ A D V +K ++ + + Sbjct: 23 SQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAI 82 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L EH N+++++D+ LV E L + P L + R Sbjct: 83 LSRVEHANIIKVLDIFENQGF-----FQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFR 137 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 Q + + +L I+HRD+K ENI++ T+KL DFG A T+ Y A Sbjct: 138 QLVSAVGYLRLKDIIHRDIKDENIVIAEDFTIKLIDFGSAAYLERGKLFYTFCGTIEYCA 197 Query: 183 PEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 PEVL+ + Y ++MWS+G + + FC +L + + PP Sbjct: 198 PEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFC------ELEETVEAAIHPPYL----- 246 Query: 242 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + + L+ +L P +R + + + ++ + Sbjct: 247 ----------------------VSKELMSLVSGLLQPVPERRTTLEKLVTDPWVTQP 281 >6DBM-A nrPDB Length = 318 Score = 190 bits (484), Expect = 5e-49, Method: Composition-based stats. Identities = 66/294 (22%), Positives = 116/294 (39%), Gaps = 38/294 (12%) Query: 4 SRY-EPVAEIGVGAYGTV----YKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVA 58 RY + + ++G G +G V Y + +G VA+K+++ G G +E+ Sbjct: 30 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQHRSG----WKQEID 85 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETI 117 +LR L H ++++ C + + LV E+V LR YL + + + Sbjct: 86 ILRTLY---HEHIIKYKGCCEDAGA---ASLQLVMEYVPLGSLRDYLPRH---SIGLAQL 136 Query: 118 KDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI----YSYQMALTP 173 +Q G+ +LH+ +HRDL N+L+ + VK+ DFGLA+ + Y Sbjct: 137 LLFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVRED 196 Query: 174 VVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 233 +++ APE L + + D+WS G E+ +S K +LIG+ Sbjct: 197 GDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHC-----DSSQSPPTKFLELIGIA 251 Query: 234 PEDDWPRDVS--LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 ++ L RG PR + L+ R + Sbjct: 252 QGQMTVLRLTELLERGERLPRP--------DKCPAEVYHLMKNCWETEASFRPT 297 >6GVJ-A nrPDB Length = 429 Score = 190 bits (483), Expect = 6e-49, Method: Composition-based stats. Identities = 71/305 (23%), Positives = 114/305 (37%), Gaps = 51/305 (16%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y + +IG G V++ + A+K V + S E+A L +L+ Sbjct: 146 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLD---SYRNEIAYLNKLQQ 201 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 ++RL D T + + +V E + DL ++L K + K + L Sbjct: 202 -HSDKIIRLYDYEITDQ-----YIYMVMECGNIDLNSWLKKKK--SIDPWERKSYWKNML 253 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA---LTPVVVTLWYRA 182 + +H + IVH DLKP N L+ G +KL DFG+A V T+ Y Sbjct: 254 EAVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMP 312 Query: 183 PEVLLQSTYATP-----------VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG 231 PE + + + D+WS+GCI M K F +Q+ K+ +I Sbjct: 313 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAIID 370 Query: 232 LPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 E ++P E+ +L L +P +RIS L Sbjct: 371 PNHEIEFPDIP----------------------EKDLQDVLKCCLKRDPKQRISIPELLA 408 Query: 292 HSYLH 296 H Y+ Sbjct: 409 HPYVQ 413 >4AT3-A nrPDB Length = 299 Score = 190 bits (483), Expect = 6e-49, Method: Composition-based stats. Identities = 61/256 (23%), Positives = 102/256 (39%), Gaps = 34/256 (13%) Query: 8 PVAEIGVGAYGTVYKARD-----PHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 E+G GA+G V+ A VA+K+++ RE LL Sbjct: 17 LKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK-----DASDNARKDFHREAELLTN 71 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKA-----------PPP 110 L +H ++V+ VC + +VFE++ DL +L PP Sbjct: 72 L---QHEHIVKFYGVCVEGDP-----LIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPT 123 Query: 111 GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY---SY 167 L + + +Q G+ +L + VHRDL N LV VK+ DFG++R Y Sbjct: 124 ELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDY 183 Query: 168 QMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKI 226 ++ + + PE ++ + T D+WS+G + E+F K + S + + I Sbjct: 184 YRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECI 243 Query: 227 FDLIGLPPEDDWPRDV 242 L P++V Sbjct: 244 TQGRVLQRPRTCPQEV 259 >2PL0-A nrPDB Length = 289 Score = 190 bits (482), Expect = 7e-49, Method: Composition-based stats. Identities = 61/283 (21%), Positives = 110/283 (38%), Gaps = 46/283 (16%) Query: 7 EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF 66 + V +G G +G V+ + VA+KS++ G P + + E L+++L Sbjct: 26 KLVERLGAGQFGEVWMGYY-NGHTKVAVKSLK------QGSMSPDAFLAEANLMKQL--- 75 Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFL 125 +H +VRL V + ++ E+++ L +L L + D+ Q Sbjct: 76 QHQRLVRLYAVVTQE------PIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIA 129 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY--QMALTPVVVTLWYRAP 183 G+ F+ +HRDL+ NILV+ + K+ADFGLAR+ A + + AP Sbjct: 130 EGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAP 189 Query: 184 EVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 E + T+ D+WS G + E+ + + G + + + + + D+ P Sbjct: 190 EAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCP--- 246 Query: 243 SLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 E QL+ P R + Sbjct: 247 -----------------------EELYQLMRLCWKERPEDRPT 266 >5A46-A nrPDB Length = 386 Score = 190 bits (482), Expect = 7e-49, Method: Composition-based stats. Identities = 60/314 (19%), Positives = 117/314 (37%), Gaps = 63/314 (20%) Query: 4 SRYEPVAEIGVGAYGTVYKA------RDPHSGH-FVALKSVRVPNGGGGGGGLPISTVRE 56 R +G G +G V A +D + VA+K ++ + E Sbjct: 40 DRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK----SDATEKDLSDLISE 95 Query: 57 VALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGL--- 112 + +++ + +H N++ L+ C ++ + ++ E+ +LR YL PPGL Sbjct: 96 MEMMKMIG--KHKNIINLLGACT-----QDGPLYVIVEYASKGNLREYLQARRPPGLEYC 148 Query: 113 -----------PAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGL 161 ++ + Q RG+++L + +HRDL N+LVT +K+ADFGL Sbjct: 149 YNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGL 208 Query: 162 AR---IYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGN 217 AR Y T + + + APE L Y D+WS G + E+F + G Sbjct: 209 ARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV 268 Query: 218 SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLT 277 + + + + + ++ + + + Sbjct: 269 PVEELFKLLKEGHRMDKPSNCTNELYMM--------------------------MRDCWH 302 Query: 278 FNPHKRISAFRALQ 291 P +R + + ++ Sbjct: 303 AVPSQRPTFKQLVE 316 >5O2B-A nrPDB Length = 285 Score = 189 bits (481), Expect = 9e-49, Method: Composition-based stats. Identities = 75/300 (25%), Positives = 123/300 (41%), Gaps = 41/300 (13%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 +++ E+G GA+ TVYK D + VA +E A + L+ Sbjct: 19 KFDI--ELGRGAFKTVYKGLDTETWVEVA----WCELQDRKLTKAEQQRFKEEAEM--LK 70 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQ 123 +HPN+VR D S + + LV E + L+TYL + + + ++ RQ Sbjct: 71 GLQHPNIVRFYDSWE-SILKGKKCIVLVTELMTSGTLKTYLKR--FKVMKPKVLRSWCRQ 127 Query: 124 FLRGLDFLHANC--IVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALTPVVVTLWY 180 L+GL FLH I+HRDLK +NI +T G+VK+ D GLA + A V+ T + Sbjct: 128 ILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFA-KSVIGTPEF 186 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 APE+ + Y VD+++ G EM + + A Q+ + P Sbjct: 187 MAPEMY-EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKP------- 238 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 300 S + +++ + N +R+S L H++ +D G Sbjct: 239 -----------------ASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTG 281 >5TOS-A nrPDB Length = 395 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 81/323 (25%), Positives = 131/323 (40%), Gaps = 46/323 (14%) Query: 1 MATSRYEPVAEIGVGAYGTVYKA---------RDPHSGHFVALKSVRVPNGGGGGGGLPI 51 +AT + P + IG G +G V+K P +G +A+K + G Sbjct: 62 LATRNFRPDSVIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKL-----NQEGFQGHR 116 Query: 52 STVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAP-- 108 + E+ L +L HPN+V+L+ C LV+E + L +L + Sbjct: 117 EWLTEINYLGQLS---HPNLVKLIGYCLEDEHR-----LLVYEFMQKGSLENHLFRRGAY 168 Query: 109 PPGLPAETIKDLMRQFLRGLDFLHAN--CIVHRDLKPENILVTSGGTVKLADFGLAR--- 163 LP ++ +GL FLH++ +++RD+K NIL+ + KL+DFGLAR Sbjct: 169 FKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNAKLSDFGLARDGP 228 Query: 164 IYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQL 223 + T V+ T Y APE + D++S G + E+ K N A + Sbjct: 229 MGDLSYVSTRVMGTYGYAAPEYMSSGHLNARSDVYSFGVLLLEILSGKRALDHNRPAKEE 288 Query: 224 GKIFDLIGLPPEDDWPR-DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHK 282 + DW R ++ R R +PE A + ++ L+F P Sbjct: 289 NLV----------DWARPYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKS 338 Query: 283 RISAFR---ALQHSYLHKDEGNP 302 R + + ALQ L + G P Sbjct: 339 RPTMDQVVRALQ--QLQDNLGKP 359 >5O2C-A nrPDB Length = 380 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 75/300 (25%), Positives = 123/300 (41%), Gaps = 41/300 (13%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 +++ E+G GA+ TVYK D + VA +E A + L+ Sbjct: 28 KFDI--ELGRGAFKTVYKGLDTETWVEVA----WCELQDRKLTKAEQQRFKEEAEM--LK 79 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQ 123 +HPN+VR D S + + LV E + L+TYL + + + ++ RQ Sbjct: 80 GLQHPNIVRFYDSWE-SILKGKKCIVLVTELMTSGTLKTYLKR--FKVMKPKVLRSWCRQ 136 Query: 124 FLRGLDFLHANC--IVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALTPVVVTLWY 180 L+GL FLH I+HRDLK +NI +T G+VK+ D GLA + A V+ T + Sbjct: 137 ILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFA-KSVIGTPEF 195 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 APE+ + Y VD+++ G EM + + A Q+ + P Sbjct: 196 MAPEMY-EEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKP------- 247 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG 300 S + +++ + N +R+S L H++ +D G Sbjct: 248 -----------------ASFNKVTDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTG 290 >4K33-A nrPDB Length = 325 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 65/317 (20%), Positives = 120/317 (37%), Gaps = 63/317 (19%) Query: 1 MATSRYEPVAEIGVGAYGTVYKA------RDPHSG-HFVALKSVRVPNGGGGGGGLPIST 53 ++ +R +G GA+G V A +D + VA+K ++ Sbjct: 33 LSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLK----DDATDKDLSDL 88 Query: 54 VREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGL 112 V E+ +++ + +H N++ L+ C + ++ E+ +LR +L PPGL Sbjct: 89 VSEMEMMKMIG--KHKNIINLLGACTQGGP-----LYVLVEYAAKGNLREFLRARRPPGL 141 Query: 113 ---------PAETIKD-----LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLAD 158 P E + Q RG+++L + +HRDL N+LVT +K+AD Sbjct: 142 DYSFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIAD 201 Query: 159 FGLARI---YSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLF 214 FGLAR Y T + + + APE L Y D+WS G + E+F + Sbjct: 202 FGLARDVHNLDYYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPY 261 Query: 215 CGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLE 274 G + + + + + D+ + ++ E Sbjct: 262 PGIPVEELFKLLKEGHRMDKPANCTHDLYM--------------------------IMRE 295 Query: 275 MLTFNPHKRISAFRALQ 291 P +R + + ++ Sbjct: 296 CWHAAPSQRPTFKQLVE 312 >4E20-A nrPDB Length = 290 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 69/293 (23%), Positives = 111/293 (37%), Gaps = 36/293 (12%) Query: 4 SRY-EPVAEIGVGAYGTV----YKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVA 58 RY + + ++G G +G V Y + +G VA+K+++ G G L RE+ Sbjct: 7 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALK----EGCGPQLRSGWQREIE 62 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETI 117 +LR L H ++V+ C E V LV E+V LR YL + + + Sbjct: 63 ILRTLY---HEHIVKYKGCCED---QGEKSVQLVMEYVPLGSLRDYLPRH---CVGLAQL 113 Query: 118 KDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI----YSYQMALTP 173 +Q G+ +LHA +HR L N+L+ + VK+ DFGLA+ + Y Sbjct: 114 LLFAQQICEGMAYLHAQHYIHRALAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVRED 173 Query: 174 VVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG-L 232 +++ APE L + + D+WS G E+ +S K +LIG Sbjct: 174 GDSPVFWYAPECLKECKFYYASDVWSFGVTLYELLT-----YCDSNQSPHTKFTELIGHT 228 Query: 233 PPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 + R L P L+ R + Sbjct: 229 QGQMTVLRLTELLERGERLPRPDRCPC-------EIYHLMKNCWETEASFRPT 274 >3KRL-A nrPDB Length = 335 Score = 189 bits (480), Expect = 1e-48, Method: Composition-based stats. Identities = 63/310 (20%), Positives = 112/310 (36%), Gaps = 60/310 (19%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHF-----VALKSVRVPNGGGGGGGLPISTVREVA 58 + + +G GA+G V +A G VA+K ++ + + E+ Sbjct: 46 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK----STAHADEKEALMSELK 101 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGL----- 112 ++ L +H N+V L+ C V ++ E+ DL +L + PPGL Sbjct: 102 IMSHLG--QHENIVNLLGACTHGGP-----VLVITEYCCYGDLLNFLRRKRPPGLEYSYN 154 Query: 113 ---------PAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR 163 + + Q +G+ FL + +HRD+ N+L+T+G K+ DFGLAR Sbjct: 155 PSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLAR 214 Query: 164 IY---SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSE 219 S + + + + APE + Y D+WS G + E+F + G Sbjct: 215 DIMNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGI-- 272 Query: 220 ADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFN 279 L + + A P P+ + S+ + Sbjct: 273 ------------LVNSKFYKLVKDGYQMAQPAFAPKNIYSI-----------MQACWALE 309 Query: 280 PHKRISAFRA 289 P R + + Sbjct: 310 PTHRPTFQQI 319 >4CRS-A nrPDB Length = 341 Score = 189 bits (480), Expect = 1e-48, Method: Composition-based stats. Identities = 64/290 (22%), Positives = 110/290 (37%), Gaps = 44/290 (15%) Query: 14 VGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVR 73 G +G V A ++ A+K+++ + + E + + + HP +V Sbjct: 22 RGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDSLMC--EKRIFETVNSVRHPFLVN 79 Query: 74 LMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLH 132 L T V V E+ DL ++ + GL +LH Sbjct: 80 LFACFQTKE-----HVCFVMEYAAGGDLMMHIHT---DVFSEPRAVFYAACVVLGLQYLH 131 Query: 133 ANCIVHRDLKPENILVTSGGTVKLADFGLARI-YSYQMALTPVVVTLWYRAPEVLLQSTY 191 + IV+RDLK +N+L+ + G VK+ADFGL + Y + T + APEVL +++Y Sbjct: 132 EHKIVYRDLKLDNLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTETSY 191 Query: 192 ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPP 251 VD W +G + EM + F G+ E + I + +V PR Sbjct: 192 TRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVN-----------DEVRYPR----- 235 Query: 252 RGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-----SAFRALQHSYLH 296 + ++ +L NP +R+ A +H + Sbjct: 236 -----------FLSTEAISIMRRLLRRNPERRLGASEKDAEDVKKHPFFR 274 >3GQL-A nrPDB Length = 326 Score = 189 bits (480), Expect = 1e-48, Method: Composition-based stats. Identities = 61/314 (19%), Positives = 118/314 (37%), Gaps = 63/314 (20%) Query: 4 SRYEPVAEIGVGAYGTVYKA------RDPHSGH-FVALKSVRVPNGGGGGGGLPISTVRE 56 R +G GA+G V A +D + VA+K ++ + E Sbjct: 28 DRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLK----SDATEKDLSDLISE 83 Query: 57 VALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGL--- 112 + +++ + +H N++ L+ C ++ + ++ E+ +LR YL PPGL Sbjct: 84 MEMMKMIG--KHKNIINLLGACT-----QDGPLYVIVEYASKGNLREYLQARRPPGLEYC 136 Query: 113 -----------PAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGL 161 ++ + Q RG+++L + +HRDL N+LVT +K+ADFGL Sbjct: 137 YNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGL 196 Query: 162 AR---IYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGN 217 AR Y T + + + APE L Y D+WS G + E+F + G Sbjct: 197 ARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV 256 Query: 218 SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLT 277 + + + + + ++ + + + Sbjct: 257 PVEELFKLLKEGHRMDKPSNCTNELYMM--------------------------MRDCWH 290 Query: 278 FNPHKRISAFRALQ 291 P +R + + ++ Sbjct: 291 AVPSQRPTFKQLVE 304 >2OGV-A nrPDB Length = 317 Score = 188 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 61/304 (20%), Positives = 109/304 (35%), Gaps = 54/304 (17%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHF-----VALKSVRVPNGGGGGGGLPISTVREVA 58 + + +G GA+G V +A G VA+K ++ + + E+ Sbjct: 38 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK----STAHADEKEALMSELK 93 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAET- 116 ++ L +H N+V L+ C V ++ E+ DL +L + L E Sbjct: 94 IMSHLG--QHENIVNLLGACTHGGP-----VLVITEYCCYGDLLNFLRRKAEADLDKEDG 146 Query: 117 -------IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY---S 166 + Q +G+ FL + +HRD+ N+L+T+G K+ DFGLAR S Sbjct: 147 RPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDS 206 Query: 167 YQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGK 225 + + + + APE + Y D+WS G + E+F + G Sbjct: 207 NYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGI-------- 258 Query: 226 IFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 L + + A P P+ + S+ + P R + Sbjct: 259 ------LVNSKFYKLVKDGYQMAQPAFAPKNIYSI-----------MQACWALEPTHRPT 301 Query: 286 AFRA 289 + Sbjct: 302 FQQI 305 >4PWN-A nrPDB Length = 274 Score = 188 bits (478), Expect = 2e-48, Method: Composition-based stats. Identities = 71/298 (23%), Positives = 121/298 (40%), Gaps = 40/298 (13%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 +++ EIG G++ TVYK D + VA +E A + L+ Sbjct: 13 KFDI--EIGRGSFKTVYKGLDTETTVEVA----WCELQDRKLTKSERQRFKEEAEM--LK 64 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQ 123 +HPN+VR D ++ ++ + LV E + L+TYL + + + ++ RQ Sbjct: 65 GLQHPNIVRFYDSWESTVKGKKC-IVLVTELMTSGTLKTYLKR--FKVMKIKVLRSWCRQ 121 Query: 124 FLRGLDFLHANC--IVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALTPVVVTLWY 180 L+GL FLH I+HRDLK +NI +T G+VK+ D GLA + V+ T + Sbjct: 122 ILKGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEF 181 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 APE+ + Y VD+++ G EM + + A Q+ + P D Sbjct: 182 MAPEMY-EEKYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFD--- 237 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 +++ + N +R S L H++ ++ Sbjct: 238 ---------------------KVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEE 274 >2PSQ-A nrPDB Length = 370 Score = 188 bits (478), Expect = 2e-48, Method: Composition-based stats. Identities = 69/301 (22%), Positives = 117/301 (38%), Gaps = 42/301 (13%) Query: 4 SRYEPVAEIGVGAYGTVYKAR-------DPHSGHFVALKSVRVPNGGGGGGGLPISTVRE 56 + +G G +G V A P VA+K ++ V E Sbjct: 81 DKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK----DDATEKDLSDLVSE 136 Query: 57 VALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGL--- 112 + +++ + +H N++ L+ C ++ + ++ E+ +LR YL PPG+ Sbjct: 137 MEMMKMIG--KHKNIINLLGACT-----QDGPLYVIVEYASKGNLREYLRARRPPGMEYS 189 Query: 113 ------PAET-----IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGL 161 P E + Q RG+++L + +HRDL N+LVT +K+ADFGL Sbjct: 190 YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGL 249 Query: 162 ARI---YSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGN 217 AR Y T + + + APE L Y D+WS G + E+F + G Sbjct: 250 ARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI 309 Query: 218 SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLT 277 + ++F L+ D P + + V S P ++ L +LT Sbjct: 310 ----PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL-DRILT 364 Query: 278 F 278 Sbjct: 365 L 365 >1K9A-A nrPDB Length = 450 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 54/291 (18%), Positives = 107/291 (36%), Gaps = 49/291 (16%) Query: 7 EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF 66 + + IG G +G V G+ VA+K ++ + E +++ +L Sbjct: 196 KLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQA-------FLAEASVMTQLR-- 244 Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 H N+V+L+ V + + +V E++ L YL L + + Sbjct: 245 -HSNLVQLLGVIVEEKGG----LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 +++L N VHRDL N+LV+ K++DFGL + S + + + APE Sbjct: 300 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL--PVKWTAPEA 357 Query: 186 LLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244 L + ++T D+WS G + E++ + + D + ++ + D P Sbjct: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP----- 412 Query: 245 PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA---LQH 292 + ++ + R + + L+H Sbjct: 413 ---------------------PAVYDVMKNCWHLDAATRPTFLQLREQLEH 442 >5KMM-A nrPDB Length = 329 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 66/302 (21%), Positives = 105/302 (34%), Gaps = 62/302 (20%) Query: 11 EIGVGAYGTVYKARDPH-----SGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 E+G GA+G V+ A + VA+K+++ + RE LL L Sbjct: 42 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQ-----DFQREAELLTML-- 94 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPP-------------PG 111 +H ++VR VC R + +VFE++ DL +L P Sbjct: 95 -QHQHIVRFFGVCTEGRP-----LLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGP 148 Query: 112 LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY---SYQ 168 L + + Q G+ +L VHRDL N LV G VK+ DFG++R Y Sbjct: 149 LGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYY 208 Query: 169 MALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIF 227 ++ + + PE +L + T D+WS G + E+F K + S + + I Sbjct: 209 RVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCIT 268 Query: 228 DLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAF 287 L P ++ P +R S Sbjct: 269 QGRELERPRACP--------------------------PEVYAIMRGCWQREPQQRHSIK 302 Query: 288 RA 289 Sbjct: 303 DV 304 >5UUU-A nrPDB Length = 547 Score = 188 bits (477), Expect = 3e-48, Method: Composition-based stats. Identities = 60/303 (19%), Positives = 111/303 (36%), Gaps = 41/303 (13%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + + + IG G +G VY R +G A+K + G + E +L Sbjct: 195 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQG--ETLALNERIML 252 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKD 119 + + P +V C + K++ + + + DL +L + ++ Sbjct: 253 SLVSTGDCPFIV-----CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRF 305 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLW 179 + + GL+ +H +V+RDLKP NIL+ G V+++D GLA +S + V T Sbjct: 306 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHG 364 Query: 180 YRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y APEVL + Y + D +S+GC+ ++ R F + D Sbjct: 365 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD----------------- 407 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-----SAFRALQHS 293 + + LL +L + ++R+ A + Sbjct: 408 -------KHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESP 460 Query: 294 YLH 296 + Sbjct: 461 FFR 463 >1S9I-A nrPDB Length = 354 Score = 188 bits (477), Expect = 3e-48, Method: Composition-based stats. Identities = 75/323 (23%), Positives = 130/323 (40%), Gaps = 40/323 (12%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + +E ++E+G G G V K + SG +A K + + + +RE+ +L Sbjct: 13 LKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLE----IKPAIRNQIIRELQVL 68 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKD 119 + P +V + + ++++ EH+D L L +A +P E + Sbjct: 69 HECNS---PYIVGFYGAFYS-----DGEISICMEHMDGGSLDQVLKEAKR--IPEEILGK 118 Query: 120 LMRQFLRGLDFL-HANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTL 178 + LRGL +L + I+HRD+KP NILV S G +KL DFG++ MA V T Sbjct: 119 VSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMA-NSFVGTR 177 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y APE L + Y+ D+WS+G E+ + + L IF + E+ Sbjct: 178 SYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKE-LEAIFGRPVVDGEEGE 236 Query: 239 PRDVSLPRGAFPP------RGPRPVQSVVPEME----------------ESGAQLLLEML 276 P +S RP ++ ++ + + + L Sbjct: 237 PHSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCL 296 Query: 277 TFNPHKRISAFRALQHSYLHKDE 299 NP +R H+++ + E Sbjct: 297 IKNPAERADLKMLTNHTFIKRSE 319 >3UIU-A nrPDB Length = 306 Score = 188 bits (477), Expect = 3e-48, Method: Composition-based stats. Identities = 65/312 (20%), Positives = 109/312 (34%), Gaps = 68/312 (21%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 ++ + IG G +G V+KA+ G ++ V+ N REV L +L Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVKYNN---------EKAEREVKALAKL- 62 Query: 65 AFEHPNVVRLMDVCATSRTDREIK------------------------VTLVFEHVD-QD 99 +H N+V D E + + E D Sbjct: 63 --DHVNIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDKGT 120 Query: 100 LRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADF 159 L +++K L +L Q +G+D++H+ ++HRDLKP NI + VK+ DF Sbjct: 121 LEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFLVDTKQVKIGDF 180 Query: 160 GLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSE 219 GL T TL Y +PE + Y VD++++G I AE+ Sbjct: 181 GLVTSLKNDGKRTRSKGTLRYMSPEQISSQDYGKEVDLYALGLILAELL----------- 229 Query: 220 ADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFN 279 D + F + + ++ LL ++L+ Sbjct: 230 ------------------HVCDTAFETSKFFTDLRDGI--ISDIFDKKEKTLLQKLLSKK 269 Query: 280 PHKRISAFRALQ 291 P R + L+ Sbjct: 270 PEDRPNTSEILR 281 >3BEA-A nrPDB Length = 333 Score = 188 bits (477), Expect = 3e-48, Method: Composition-based stats. Identities = 60/308 (19%), Positives = 108/308 (35%), Gaps = 58/308 (18%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHF-----VALKSVRVPNGGGGGGGLPISTVREVA 58 + + +G GA+G V +A G VA+K ++ + + E+ Sbjct: 46 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK----STAHADEKEALMSELK 101 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPP-------- 109 ++ L +H N+V L+ C V ++ E+ DL +L + Sbjct: 102 IMSHLG--QHENIVNLLGACTHGGP-----VLVITEYCCYGDLLNFLRRKSRVLETDPAF 154 Query: 110 ----PGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY 165 L + Q +G+ FL + +HRD+ N+L+T+G K+ DFGLAR Sbjct: 155 AIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDI 214 Query: 166 ---SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEAD 221 S + + + + APE + Y D+WS G + E+F + G Sbjct: 215 MNDSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGI---- 270 Query: 222 QLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPH 281 L + + A P P+ + S+ + P Sbjct: 271 ----------LVNSKFYKLVKDGYQMAQPAFAPKNIYSI-----------MQACWALEPT 309 Query: 282 KRISAFRA 289 R + + Sbjct: 310 HRPTFQQI 317 >4M7I-A nrPDB Length = 299 Score = 187 bits (476), Expect = 4e-48, Method: Composition-based stats. Identities = 63/290 (21%), Positives = 116/290 (40%), Gaps = 32/290 (11%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 +EP+ +G G +G V++A++ A+K +R+PN +REV L +L Sbjct: 6 DFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELA----REKVMREVKALAKL- 60 Query: 65 AFEHPNVVRLMDVCATSRTDREI-------KVTLVFEHVDQ-DLRTYLDKAPPPGLPAET 116 EHP +VR + T ++ + + + + +L+ +++ + Sbjct: 61 --EHPGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERS 118 Query: 117 I-KDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM------ 169 + + Q ++FLH+ ++HRDLKP NI T VK+ DFGL Sbjct: 119 VCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVL 178 Query: 170 -------ALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQ 222 T V T Y +PE + ++Y+ VD++S+G I E+ P Sbjct: 179 TPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELL--YPFSTQMERVRT 236 Query: 223 LGKIFDLIGLP-PEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQL 271 L + +L P +P + + + P +++ L Sbjct: 237 LTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDL 286 >3PVW-A nrPDB Length = 695 Score = 187 bits (475), Expect = 5e-48, Method: Composition-based stats. Identities = 60/303 (19%), Positives = 111/303 (36%), Gaps = 41/303 (13%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + + + IG G +G VY R +G A+K + G + E +L Sbjct: 186 LTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQG--ETLALNERIML 243 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKD 119 + + P +V C + K++ + + + DL +L + ++ Sbjct: 244 SLVSTGDCPFIV-----CMSYAFHTPDKLSFILDLMNGGDLHYHLSQHG--VFSEADMRF 296 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLW 179 + + GL+ +H +V+RDLKP NIL+ G V+++D GLA +S + V T Sbjct: 297 YAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFS-KKKPHASVGTHG 355 Query: 180 YRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y APEVL + Y + D +S+GC+ ++ R F + D Sbjct: 356 YMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKD----------------- 398 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI-----SAFRALQHS 293 + + LL +L + ++R+ A + Sbjct: 399 -------KHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESP 451 Query: 294 YLH 296 + Sbjct: 452 FFR 454 >4H1J-A nrPDB Length = 293 Score = 187 bits (475), Expect = 6e-48, Method: Composition-based stats. Identities = 55/286 (19%), Positives = 96/286 (33%), Gaps = 45/286 (15%) Query: 10 AEIGVGAYGTVYKAR---DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF 66 +G G +G VY+ VA+K+ + + E +++ L Sbjct: 30 RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNK----EKFMSEAVIMKNL--- 82 Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLR 126 +HP++V+L+ + T ++ E + + L T+ Q + Sbjct: 83 DHPHIVKLIGIIEEEPT------WIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICK 136 Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV--TLWYRAPE 184 + +L + VHRD+ NILV S VKL DFGL+R + V + + +PE Sbjct: 137 AMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPE 196 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 + + T D+W E+ K F D +G + LP D P + Sbjct: 197 SINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLY 256 Query: 244 LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 L+ ++P R Sbjct: 257 T--------------------------LMTRCWDYDPSDRPRFTEL 276 >6FEX-A nrPDB Length = 321 Score = 187 bits (474), Expect = 6e-48, Method: Composition-based stats. Identities = 69/329 (20%), Positives = 120/329 (36%), Gaps = 68/329 (20%) Query: 4 SRYEPVAEIGVGAYGTVYKAR--------------DPHSGH--FVALKSVRVPNGGGGGG 47 SR ++G G +G V+ + GH VA+K +R Sbjct: 16 SRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR----PDATK 71 Query: 48 GLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDK 106 ++EV ++ RL+ PN++RL+ VC ++ + ++ ++++ DL +L Sbjct: 72 NARNDFLKEVKIMSRLKD---PNIIRLLGVCV-----QDDPLCMITDYMENGDLNQFLSA 123 Query: 107 AP-----------PPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVK 155 P + + + Q G+ +L VHRDL N LV T+K Sbjct: 124 HQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIK 183 Query: 156 LADFGLARIY---SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAE--MFRR 210 +ADFG++R Y V+ + + A E +L + T D+W+ G E M R Sbjct: 184 IADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCR 243 Query: 211 KPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGA- 269 F ++ + G F R V P G Sbjct: 244 AQPFGQLTDEQVIEN--------------------AGEFFRDQGRQVYLSRPPACPQGLY 283 Query: 270 QLLLEMLTFNPHKRISAFRALQHSYLHKD 298 +L+L + +R + H +L +D Sbjct: 284 ELMLRCWSRESEQRPPFSQL--HRFLAED 310 >2HK5-A nrPDB Length = 270 Score = 186 bits (473), Expect = 9e-48, Method: Composition-based stats. Identities = 56/264 (21%), Positives = 108/264 (40%), Gaps = 26/264 (9%) Query: 7 EPVAEIGVGAYGTVYKA-RDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 + ++G G +G V+ A + H+ VA+K+++ G + + E +++ L Sbjct: 18 KLEKKLGAGQFGEVWMATYNKHTK--VAVKTMK------PGSMSVEAFLAEANVMKTL-- 67 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQF 124 +H +V+L V + ++ E + L +L P + D Q Sbjct: 68 -QHDKLVKLHAVVTKE------PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQI 120 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY--QMALTPVVVTLWYRA 182 G+ F+ +HRDL+ NILV++ K+ADFGLAR+ A + + A Sbjct: 121 AEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTA 180 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 PE + ++ D+WS G + E+ + + G S + + + +P ++ P + Sbjct: 181 PEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEE 240 Query: 242 VSLPRGAFPPRGPRPVQSVVPEME 265 + R + P E Sbjct: 241 L----YNIMMRCWKNRPEERPTFE 260 >4HVI-A nrPDB Length = 314 Score = 186 bits (473), Expect = 9e-48, Method: Composition-based stats. Identities = 67/288 (23%), Positives = 117/288 (40%), Gaps = 32/288 (11%) Query: 7 EPVAEIGVGAYGTVYKAR----DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + ++++G G +G+V R ++G VA+K + G RE+ +L+ Sbjct: 13 KYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQL-----QHSGPDQQRDFQREIQILKA 67 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLM 121 L + +V+ V S + LV E++ LR +L + L A + Sbjct: 68 LHS---DFIVKYRGV---SYGPGRQSLRLVMEYLPSGCLRDFLQRHRAR-LDASRLLLYS 120 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALTPVVVT 177 Q +G+++L + VHRDL NILV S VK+ADFGLA++ Y + P Sbjct: 121 SQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSP 180 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 +++ APE L + ++ D+WS G + E+F C S + + ++ P Sbjct: 181 IFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSC--SPSAEFLRMMGSERDVPALS 238 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 ++ P P +L+ +P R S Sbjct: 239 RLLELLEEGQRLPAPPACP---------AEVHELMKLCWAPSPQDRPS 277 >6BSD-A nrPDB Length = 876 Score = 186 bits (473), Expect = 9e-48, Method: Composition-based stats. Identities = 70/335 (20%), Positives = 121/335 (36%), Gaps = 74/335 (22%) Query: 4 SRYEPVAEIGVGAYGTVYKAR--------------DPHSGH--FVALKSVRVPNGGGGGG 47 SR ++G G +G V+ + GH VA+K +R Sbjct: 571 SRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILR----PDATK 626 Query: 48 GLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYL-- 104 ++EV ++ RL+ PN++RL+ VC ++ + ++ ++++ DL +L Sbjct: 627 NARNDFLKEVKIMSRLKD---PNIIRLLGVCV-----QDDPLCMITDYMENGDLNQFLSA 678 Query: 105 ---------------DKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT 149 A P + + + Q G+ +L VHRDL N LV Sbjct: 679 HQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVG 738 Query: 150 SGGTVKLADFGLARIY---SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAE 206 T+K+ADFG++R Y V+ + + A E +L + T D+W+ G E Sbjct: 739 ENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWE 798 Query: 207 --MFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEM 264 M R F ++ + G F R V P Sbjct: 799 VLMLCRAQPFGQLTDEQVIEN--------------------AGEFFRDQGRQVYLSRPPA 838 Query: 265 EESGA-QLLLEMLTFNPHKRISAFRALQHSYLHKD 298 G +L+L + +R + H +L +D Sbjct: 839 CPQGLYELMLRCWSRESEQRPPFSQL--HRFLAED 871 >6FER-A nrPDB Length = 309 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 66/311 (21%), Positives = 116/311 (37%), Gaps = 61/311 (19%) Query: 9 VAEIGVGAYGTVYKAR--------------DPHSGH--FVALKSVRVPNGGGGGGGLPIS 52 ++G G +G V+ D + VA+K +R Sbjct: 14 KEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLR----ADANKNARND 69 Query: 53 TVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPG 111 ++E+ ++ RL+ PN++ L+ VC T + ++ E+++ DL +L + PP Sbjct: 70 FLKEIKIMSRLKD---PNIIHLLAVCITDDP-----LCMITEYMENGDLNQFLSRHEPPN 121 Query: 112 LPAETIK--------DLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR 163 + ++ + Q G+ +L + VHRDL N LV T+K+ADFG++R Sbjct: 122 SSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSR 181 Query: 164 IY---SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEA 220 Y V+ + + + E +L + T D+W+ G E F FC Sbjct: 182 NLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFT----FCQEQPY 237 Query: 221 DQL--GKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTF 278 QL ++ + G D R + P+ SV L+L Sbjct: 238 SQLSDEQVIENTGEFFRDQ-------GRQTYLPQPAICPDSVYK--------LMLSCWRR 282 Query: 279 NPHKRISAFRA 289 + R S Sbjct: 283 DTKNRPSFQEI 293 >3HMP-A nrPDB Length = 342 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 71/305 (23%), Positives = 114/305 (37%), Gaps = 51/305 (16%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y + +IG G V++ + A+K V + S E+A L +L+ Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLD---SYRNEIAYLNKLQQ 113 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 ++RL D T + + +V E + DL ++L K + K + L Sbjct: 114 -HSDKIIRLYDYEITDQ-----YIYMVMECGNIDLNSWLKKKK--SIDPWERKSYWKNML 165 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA---LTPVVVTLWYRA 182 + +H + IVH DLKP N L+ G +KL DFG+A V T+ Y Sbjct: 166 EAVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMP 224 Query: 183 PEVLLQSTYATP-----------VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG 231 PE + + + D+WS+GCI M K F +Q+ K+ +I Sbjct: 225 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAIID 282 Query: 232 LPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 E ++P E+ +L L +P +RIS L Sbjct: 283 PNHEIEFPDIP----------------------EKDLQDVLKCCLKRDPKQRISIPELLA 320 Query: 292 HSYLH 296 H Y+ Sbjct: 321 HPYVQ 325 >1ZXE-A nrPDB Length = 303 Score = 185 bits (471), Expect = 1e-47, Method: Composition-based stats. Identities = 80/328 (24%), Positives = 123/328 (37%), Gaps = 61/328 (18%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 S +E +A +G GA+G V KAR+ + A+K +R + + EV LL Sbjct: 5 ASDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLS------TILSEVMLLAS 58 Query: 63 LEAFEHPNVVRLMDVCATSRT--------DREIKVTLVFEHVDQDLRTYLDKAPPPGLPA 114 L H VVR R ++ + + E+ + L + Sbjct: 59 L---NHQYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQR 115 Query: 115 ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS-------- 166 + L RQ L L ++H+ I+HR+LKP NI + VK+ DFGLA+ Sbjct: 116 DEYWRLFRQILEALSYIHSQGIIHRNLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILKL 175 Query: 167 -------YQMALTPVVVTLWYRAPEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNS 218 LT + T Y A EVL Y +DM+S+G IF EM P G Sbjct: 176 DSQNLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMI--YPFSTGME 233 Query: 219 EADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTF 278 + L K+ + P D + + + + ++ Sbjct: 234 RVNILKKLRSVSIEFPPDFDDNKMKVEKKI-----------------------IRLLIDH 270 Query: 279 NPHKRISAFRALQHSYL---HKDEGNPE 303 +P+KR A L +L H+DE E Sbjct: 271 DPNKRPGARTLLNSGWLPVKHQDEVIKE 298 >3BBT-B nrPDB Length = 328 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 59/290 (20%), Positives = 108/290 (37%), Gaps = 27/290 (9%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFV----ALKSVRVPNGGGGGGGLPISTVRE 56 + + + V +G GA+GTVYK G V A+K + G + + E Sbjct: 12 LKETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILN----ETTGPKANVEFMDE 67 Query: 57 VALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAET 116 ++ + +HP++VRL+ VC + + LV + + + ++ Sbjct: 68 ALIMASM---DHPHLVRLLGVCLSPT------IQLVTQLMPHGCLLEYVHEHKDNIGSQL 118 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV 176 + + Q +G+ +L +VHRDL N+LV S VK+ DFGLAR+ Sbjct: 119 LLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADG 178 Query: 177 ---TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGL 232 + + A E + + D+WS G E+ + G + + L Sbjct: 179 GKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERL 238 Query: 233 PPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHK 282 P ++ + P+ +E A+ M +P + Sbjct: 239 PQPPIC----TIDVYMVMVKCWMIDADSRPKFKELAAEF-SRM-ARDPQR 282 >3QUP-A nrPDB Length = 323 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 61/295 (20%), Positives = 110/295 (37%), Gaps = 45/295 (15%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSG---HFVALKSVRVPNGGGGGGGLPISTVREVALL 60 ++ +G G +G+V +A+ VA+K ++ +RE A + Sbjct: 23 QQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDI---EEFLREAACM 79 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLV-FEHVD-QDLRTYLDKAP----PPGLPA 114 + F+HP+V +L+ V SR + + +V + DL +L + P LP Sbjct: 80 KE---FDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPL 136 Query: 115 ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPV 174 +T+ M G+++L + +HRDL N ++ TV +ADFGL+R Sbjct: 137 QTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQG 196 Query: 175 VVTL---WYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLI 230 + + A E L + Y D+W+ G E+ + + G A+ + Sbjct: 197 CASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGN 256 Query: 231 GLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 L PE E L+ + + +P +R S Sbjct: 257 RL--------------------------KQPPECMEEVYDLMYQCWSADPKQRPS 285 >1BYG-A nrPDB Length = 278 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 55/291 (18%), Positives = 108/291 (37%), Gaps = 49/291 (16%) Query: 7 EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF 66 + + IG G +G V G+ VA+K ++ + E +++ +L Sbjct: 24 KLLQTIGKGEFGDVMLGDYR--GNKVAVKCIKNDATAQA-------FLAEASVMTQLR-- 72 Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 H N+V+L+ V + + +V E++ L YL L + + Sbjct: 73 -HSNLVQLLGVIVEEKGG----LYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC 127 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 +++L N VHRDL N+LV+ K++DFGL + S + + + APE Sbjct: 128 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKL--PVKWTAPEA 185 Query: 186 LLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244 L + ++T D+WS G + E++ + + D + ++ + D P Sbjct: 186 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP----- 240 Query: 245 PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA---LQH 292 + +++ + R S + L+H Sbjct: 241 ---------------------PAVYEVMKNCWHLDAAMRPSFLQLREQLEH 270 >4XUF-A nrPDB Length = 297 Score = 184 bits (467), Expect = 5e-47, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 108/313 (34%), Gaps = 67/313 (21%) Query: 4 SRYEPVAEIGVGAYGTVYKARD---PHSG--HFVALKSVRVPNGGGGGGGLPISTVREVA 58 E +G GA+G V A +G VA+K ++ + + E+ Sbjct: 9 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK----EKADSSEREALMSELK 64 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPG------ 111 ++ +L + H N+V L+ C S + L+FE+ DL YL Sbjct: 65 MMTQLGS--HENIVNLLGACTLSGP-----IYLIFEYCCYGDLLNYLRSKREKFSEDEIE 117 Query: 112 ---------------LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKL 156 L E + Q +G++FL VHRDL N+LVT G VK+ Sbjct: 118 YENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKI 177 Query: 157 ADFGLARIY---SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKP 212 DFGLAR S + + + + APE L + Y D+WS G + E+F Sbjct: 178 CDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVN 237 Query: 213 LFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLL 272 + G K+ + + + ++ Sbjct: 238 PYPGIPVDANFYKLIQNGFKMDQPFYATEEIYI-------------------------IM 272 Query: 273 LEMLTFNPHKRIS 285 F+ KR S Sbjct: 273 QSCWAFDSRKRPS 285 >3ZBF-A nrPDB Length = 322 Score = 183 bits (466), Expect = 6e-47, Method: Composition-based stats. Identities = 70/295 (23%), Positives = 113/295 (38%), Gaps = 59/295 (20%) Query: 12 IGVGAYGTVYKARDPH-----SGH-FVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +G GA+G VY+ SG VA+K+++ G I ++E L+ + Sbjct: 41 LGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKK----GSTDQEKIEFLKEAHLMSK--- 93 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGL-----PAETIKD 119 F HPN+++ + VC + ++ E ++ DL TYL KA + D Sbjct: 94 FNHPNILKQLGVCLLNEPQ-----YIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVD 148 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILV-----TSGGTVKLADFGLARIY---SYQMAL 171 L +G +L +HRDL N LV TS VK+ DFGLAR Y Sbjct: 149 LCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKR 208 Query: 172 TPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLI 230 ++ + + APE L+ + T D+WS G + E+ + +S D L + Sbjct: 209 GEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGG 268 Query: 231 GLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 L P + P + L+ + P +R + Sbjct: 269 RLEPPRNCP--------------------------DDLWNLMTQCWAQEPDQRPT 297 >4R7H-A nrPDB Length = 343 Score = 183 bits (465), Expect = 7e-47, Method: Composition-based stats. Identities = 63/317 (19%), Positives = 110/317 (34%), Gaps = 67/317 (21%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHF-----VALKSVRVPNGGGGGGGLPISTVREVA 58 + + +G GA+G V +A G VA+K ++ + + E+ Sbjct: 50 NNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLK----STAHADEKEALMSELK 105 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYL------------- 104 ++ L +H N+V L+ C V ++ E+ DL +L Sbjct: 106 IMSHLG--QHENIVNLLGACTHGGP-----VLVITEYCTYGDLLNFLRRKAEAMLGPSLS 158 Query: 105 --------DKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKL 156 DK L + Q +G+ FL + +HRD+ N+L+T+G K+ Sbjct: 159 PGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKI 218 Query: 157 ADFGLARIY---SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKP 212 DFGLAR S + + + + APE + S Y D+WS G + E+F Sbjct: 219 GDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDSVYTVQSDVWSYGILLWEIFSLGLN 278 Query: 213 LFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLL 272 + G L + + A P P+ + S+ + Sbjct: 279 PYPGI--------------LVNSKFYKLVKDGYQMAQPAFAPKNIYSI-----------M 313 Query: 273 LEMLTFNPHKRISAFRA 289 P R + + Sbjct: 314 QACWALEPTHRPTFQQI 330 >5AP3-A nrPDB Length = 313 Score = 183 bits (465), Expect = 7e-47, Method: Composition-based stats. Identities = 71/305 (23%), Positives = 113/305 (37%), Gaps = 51/305 (16%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y + +IG G V++ + A+K V + S E+A L +L+ Sbjct: 30 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLD---SYRNEIAYLNKLQQ 85 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 ++RL D T + + +V E + DL +L K + K + L Sbjct: 86 -HSDKIIRLYDYEITDQ-----YIYMVMECGNIDLNGWLKKKK--SIDPWERKSYWKNML 137 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA---LTPVVVTLWYRA 182 + +H + IVH DLKP N L+ G +KL DFG+A V T+ Y Sbjct: 138 EAVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMP 196 Query: 183 PEVLLQSTYATP-----------VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG 231 PE + + + D+WS+GCI M K F +Q+ K+ +I Sbjct: 197 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAIID 254 Query: 232 LPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 E ++P E+ +L L +P +RIS L Sbjct: 255 PNHEIEFPDIP----------------------EKDLQDVLKCCLKRDPKQRISIPELLA 292 Query: 292 HSYLH 296 H Y+ Sbjct: 293 HPYVQ 297 >2ZMD-A nrPDB Length = 390 Score = 183 bits (465), Expect = 8e-47, Method: Composition-based stats. Identities = 70/305 (22%), Positives = 113/305 (37%), Gaps = 51/305 (16%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y + +IG G V++ + A+K V + S E+A L +L+ Sbjct: 58 YSILKQIGSGGSSKVFQVLN-EKKQIYAIKYVNLEEADNQTLD---SYRNEIAYLNKLQQ 113 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 ++RL D T + + +V E + DL ++L K + K + L Sbjct: 114 -HSDKIIRLYDYEITDQ-----YIYMVMECGNIDLNSWLKKKK--SIDPWERKSYWKNML 165 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA---LTPVVVTLWYRA 182 + +H + IVH DLKP N L+ G +KL DFG+A V + Y Sbjct: 166 EAVHTIHQHGIVHSDLKPANFLIV-DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMP 224 Query: 183 PEVLLQSTYATP-----------VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG 231 PE + + + D+WS+GCI M K F +Q+ K+ +I Sbjct: 225 PEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQ--QIINQISKLHAIID 282 Query: 232 LPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 E ++P E+ +L L +P +RIS L Sbjct: 283 PNHEIEFPDIP----------------------EKDLQDVLKCCLKRDPKQRISIPELLA 320 Query: 292 HSYLH 296 H Y+ Sbjct: 321 HPYVQ 325 >1AD5-A nrPDB Length = 438 Score = 183 bits (465), Expect = 8e-47, Method: Composition-based stats. Identities = 55/262 (20%), Positives = 107/262 (40%), Gaps = 32/262 (12%) Query: 7 EPVAEIGVGAYGTVYKA-RDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 + ++G G +G V+ A + H+ VA+K+++ G + + E +++ L Sbjct: 185 KLEKKLGAGQFGEVWMATYNKHTK--VAVKTMK------PGSMSVEAFLAEANVMKTL-- 234 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQF 124 +H +V+L V + ++ E + L +L P + D Q Sbjct: 235 -QHDKLVKLHAVVTKE------PIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQI 287 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 G+ F+ +HRDL+ NILV++ K+ADFGLAR+ + + APE Sbjct: 288 AEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARV--------GAKFPIKWTAPE 339 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 + ++ D+WS G + E+ + + G S + + + +P ++ P ++ Sbjct: 340 AINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEEL- 398 Query: 244 LPRGAFPPRGPRPVQSVVPEME 265 R + P E Sbjct: 399 ---YNIMMRCWKNRPEERPTFE 417 >5HI2-A nrPDB Length = 283 Score = 183 bits (465), Expect = 8e-47, Method: Composition-based stats. Identities = 71/303 (23%), Positives = 122/303 (40%), Gaps = 54/303 (17%) Query: 2 ATSRYEP-------VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTV 54 ++ +E IG G++GTVYK + VA+K + + Sbjct: 11 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML--------TPQQLQAFK 59 Query: 55 REVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPA 114 EV +LR+ H N++ M + + +V + + + A Sbjct: 60 NEVGVLRK---TRHVNILLFMGYSTKPQ------LAIVTQWCEGSSLYHHLHASETKFEM 110 Query: 115 ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI---YSYQMAL 171 + + D+ RQ RG+D+LHA I+HRDLK NI + TVK+ DFGLA + +S Sbjct: 111 KKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSGSHQF 170 Query: 172 TPVVVTLWYRAPEVLL---QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD 228 + ++ + APEV+ + Y+ D+++ G + E+ + + + DQ+ ++ Sbjct: 171 EQLSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVG 230 Query: 229 LIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFR 288 L P D+S R P R +L+ E L +R S R Sbjct: 231 RGSLSP------DLSKVRSNCPKR---------------MKRLMAECLKKKRDERPSFPR 269 Query: 289 ALQ 291 L Sbjct: 270 ILA 272 >5X02-A nrPDB Length = 347 Score = 183 bits (465), Expect = 9e-47, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 108/313 (34%), Gaps = 67/313 (21%) Query: 4 SRYEPVAEIGVGAYGTVYKARD---PHSG--HFVALKSVRVPNGGGGGGGLPISTVREVA 58 E +G GA+G V A +G VA+K ++ + + E+ Sbjct: 48 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK----EKADSSEREALMSELK 103 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPG------ 111 ++ +L + H N+V L+ C S + L+FE+ DL YL Sbjct: 104 MMTQLGS--HENIVNLLGACTLSGP-----IYLIFEYCCYGDLLNYLRSKREKFSEDEIE 156 Query: 112 ---------------LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKL 156 L E + Q +G++FL VHRDL N+LVT G VK+ Sbjct: 157 YENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKI 216 Query: 157 ADFGLARIY---SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKP 212 DFGLAR S + + + + APE L + Y D+WS G + E+F Sbjct: 217 CDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVN 276 Query: 213 LFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLL 272 + G K+ + + + ++ Sbjct: 277 PYPGIPVDANFYKLIQNGFKMDQPFYATEEIYI-------------------------IM 311 Query: 273 LEMLTFNPHKRIS 285 F+ KR S Sbjct: 312 QSCWAFDSRKRPS 324 >5EG3-A nrPDB Length = 334 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 68/301 (22%), Positives = 117/301 (38%), Gaps = 42/301 (13%) Query: 4 SRYEPVAEIGVGAYGTVYKAR-------DPHSGHFVALKSVRVPNGGGGGGGLPISTVRE 56 + +G GA+G V A P VA+K ++ V E Sbjct: 35 DKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLK----DDATEKDLSDLVSE 90 Query: 57 VALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGL--- 112 + +++ + +H N++ L+ C ++ + ++ + +LR YL PPG+ Sbjct: 91 MEMMKMIG--KHKNIINLLGACT-----QDGPLYVIVAYASKGNLREYLRARRPPGMELS 143 Query: 113 ------PAET-----IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGL 161 P E + Q RG+++L + +HRDL N+LVT +K+ADFGL Sbjct: 144 PDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGL 203 Query: 162 ARI---YSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGN 217 AR + T + + + APE L Y D+WS G + E+F + G Sbjct: 204 ARDINNIDFFKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI 263 Query: 218 SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLT 277 + ++F L+ D P + + V S P ++ L +LT Sbjct: 264 ----PVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL-DRILT 318 Query: 278 F 278 Sbjct: 319 L 319 >5B2L-A nrPDB Length = 324 Score = 183 bits (464), Expect = 1e-46, Method: Composition-based stats. Identities = 61/305 (20%), Positives = 113/305 (37%), Gaps = 43/305 (14%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + E + E+G G G V+K R +GH +A+K +R + + Sbjct: 16 INDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLD------VV 69 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 L++ + P +V+ T+ V + E + L K +P + + Sbjct: 70 LKSHDCPYIVQCFGTFITNTD-----VFIAMELMGTSAEK-LKKRMQGPIPERILGKMTV 123 Query: 123 QFLRGLDFL-HANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYR 181 ++ L +L + ++HRD+KP NIL+ G +KL DFG++ A T Y Sbjct: 124 AIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYM 183 Query: 182 APEVLL-----QSTYATPVDMWSVGCIFAEMFRRKPLFCG-NSEADQLGKIFDLIGLPPE 235 APE + + Y D+WS+G E+ + + ++ + L K+ Sbjct: 184 APERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQ------- 236 Query: 236 DDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 P+ + + LT + KR + L+HS++ Sbjct: 237 -----------------EEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFI 279 Query: 296 HKDEG 300 + E Sbjct: 280 KRYET 284 >3SXS-A nrPDB Length = 268 Score = 182 bits (463), Expect = 1e-46, Method: Composition-based stats. Identities = 58/294 (19%), Positives = 110/294 (37%), Gaps = 46/294 (15%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + + E+G G +G V + + VA+K ++ G +E + Sbjct: 5 LKREEITLLKELGSGQFGVVKLGKWKG-QYDVAVKMIK------EGSMSEDEFFQEAQTM 57 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 +L HP +V+ VC+ +E + +V E++ ++ GL + ++ Sbjct: 58 MKLS---HPKLVKFYGVCS-----KEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEM 109 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLW- 179 G+ FL ++ +HRDL N LV VK++DFG+ R Y V T + Sbjct: 110 CYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTR-YVLDDQYVSSVGTKFP 168 Query: 180 --YRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPED 236 + APEV Y++ D+W+ G + E+F K + + ++ + K+ L Sbjct: 169 VKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPH 228 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRAL 290 ++ Q++ P KR + + L Sbjct: 229 L--------------------------ASDTIYQIMYSCWHELPEKRPTFQQLL 256 >3CJF-A nrPDB Length = 309 Score = 182 bits (463), Expect = 1e-46, Method: Composition-based stats. Identities = 65/309 (21%), Positives = 109/309 (35%), Gaps = 55/309 (17%) Query: 4 SRYEPVAEIGVGAYGTVYKA----RDP-HSGHFVALKSVRVPNGGGGGGGLPISTVREVA 58 R +G GA+G V +A D + VA+K ++ G + + E+ Sbjct: 27 DRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK----EGATHSEHRALMSELK 82 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPG------ 111 +L + H NVV L+ C + ++ E +L TYL Sbjct: 83 IL--IHIGHHLNVVNLLGACTKPG----GPLMVIVEFCKFGNLSTYLRSKRNEFVPYKDL 136 Query: 112 ----LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-- 165 L E + Q +G++FL + +HRDL NIL++ VK+ DFGLAR Sbjct: 137 YKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYK 196 Query: 166 -SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQL 223 + + L + APE + Y D+WS G + E+F + G ++ Sbjct: 197 DPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEF 256 Query: 224 GKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKR 283 + D+ PEM ++ P +R Sbjct: 257 CRRLKEGTRMRAPDY---------------------TTPEMYQTMLD----CWHGEPSQR 291 Query: 284 ISAFRALQH 292 + ++H Sbjct: 292 PTFSELVEH 300 >4HZS-A nrPDB Length = 341 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 73/301 (24%), Positives = 116/301 (38%), Gaps = 34/301 (11%) Query: 1 MATSRYEPVAEIGVGAYGTVYKAR-DPHSGHFV--ALKSVRVPNGGGGGGGLPISTVREV 57 + + ++G G++G V + D SG V A+K ++ +REV Sbjct: 9 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMD--DFIREV 66 Query: 58 ALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAET 116 + L +H N++RL V T + +V E L L K L T Sbjct: 67 NAMHSL---DHRNLIRLYGVVLTP------PMKMVTELAPLGSLLDRLRKHQGHFL-LGT 116 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALT 172 + Q G+ +L + +HRDL N+L+ + VK+ DFGL R + + Sbjct: 117 LSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQE 176 Query: 173 PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKI-FDLI 230 V + APE L T++ D W G EMF + + G + + L KI + Sbjct: 177 HRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGE 236 Query: 231 GLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRAL 290 LP +D P+D+ + PE + L +L P + RAL Sbjct: 237 RLPRPEDCPQDIY--------NVMVQCWAHKPEDRPTFVALRDFLLEAQP----TDMRAL 284 Query: 291 Q 291 Q Sbjct: 285 Q 285 >5VD3-A nrPDB Length = 311 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 75/294 (25%), Positives = 111/294 (37%), Gaps = 42/294 (14%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL-RRLE 64 ++ ++ +G G+YG V+K R G A+K P G P R++A + + Sbjct: 59 FQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRG------PKDRARKLAEVGSHEK 112 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 +HP VRL + L E L+ + + A LP + +R Sbjct: 113 VGQHPCCVRLEQAWEEGGI-----LYLQTELCGPSLQQHCE-AWGASLPEAQVWGYLRDT 166 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPE 184 L L LH+ +VH D+KP NI + G KL DFGL A Y APE Sbjct: 167 LLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPE 226 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSL 244 LLQ +Y T D++S+G E+ L G QL + + LPPE Sbjct: 227 -LLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGY----LPPE--------- 272 Query: 245 PRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKD 298 + +L+ ML +P R +A L L + Sbjct: 273 ---------------FTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQP 311 >2W1I-A nrPDB Length = 326 Score = 182 bits (461), Expect = 2e-46, Method: Composition-based stats. Identities = 65/292 (22%), Positives = 116/292 (39%), Gaps = 31/292 (10%) Query: 7 EPVAEIGVGAYGTVYKAR----DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + + ++G G +G+V R ++G VA+K + RE+ +L+ Sbjct: 44 KFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL-----QHSTEEHLRDFEREIEILKS 98 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLM 121 L +H N+V+ VC ++ + L+ E++ LR YL K + + Sbjct: 99 L---QHDNIVKYKGVCYSAGRRN---LKLIMEYLPYGSLRDYLQKHK-ERIDHIKLLQYT 151 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALTPVVVT 177 Q +G+++L +HRDL NILV + VK+ DFGL ++ Y P Sbjct: 152 SQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESP 211 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 +++ APE L +S ++ D+WS G + E+F + +IG + Sbjct: 212 IFWYAPESLTESKFSVASDVWSFGVVLYELFT-----YIEKSKSPPAEFMRMIGNDKQGQ 266 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 + R PRP + ++ E N ++R S Sbjct: 267 MIVFHLIELLKNNGRLPRP-----DGCPDEIYMIMTECWNNNVNQRPSFRDL 313 >5HVK-A nrPDB Length = 315 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 66/302 (21%), Positives = 117/302 (38%), Gaps = 54/302 (17%) Query: 10 AEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHP 69 +G G +G K +G + +K + + + ++EV ++R L EHP Sbjct: 20 EVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEET-----QRTFLKEVKVMRCL---EHP 71 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 NV++ + V + ++ + E++ + K+ P + G+ Sbjct: 72 NVLKFIGVLYKDK-----RLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMA 126 Query: 130 FLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ---------------MALTPV 174 +LH+ I+HR+L N LV V +ADFGLAR+ + V Sbjct: 127 YLHSMNIIHRNLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTV 186 Query: 175 VVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 V ++ APE++ +Y VD++S G + E+ R N++ D L P Sbjct: 187 VGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRV-----NADPDYL---------PR 232 Query: 235 EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSY 294 D+ +V + P P S P + +P KR S + L+H + Sbjct: 233 TMDFGLNVRGFLDRYCPPNCPP--SFFPIT--------VRCCDLDPEKRPSFVK-LEH-W 280 Query: 295 LH 296 L Sbjct: 281 LE 282 >3IO7-A nrPDB Length = 313 Score = 181 bits (459), Expect = 3e-46, Method: Composition-based stats. Identities = 65/292 (22%), Positives = 116/292 (39%), Gaps = 31/292 (10%) Query: 7 EPVAEIGVGAYGTVYKAR----DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + + ++G G +G+V R ++G VA+K + RE+ +L+ Sbjct: 31 KFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL-----QHSTEEHLRDFEREIEILKS 85 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLM 121 L +H N+V+ VC ++ + L+ E++ LR YL K + + Sbjct: 86 L---QHDNIVKYKGVCYSAGRRN---LKLIMEYLPYGSLRDYLQKHK-ERIDHIKLLQYT 138 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALTPVVVT 177 Q +G+++L +HRDL NILV + VK+ DFGL ++ Y P Sbjct: 139 SQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESP 198 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 +++ APE L +S ++ D+WS G + E+F + +IG + Sbjct: 199 IFWYAPESLTESKFSVASDVWSFGVVLYELFT-----YIEKSKSPPAEFMRMIGNDKQGQ 253 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 + R PRP + ++ E N ++R S Sbjct: 254 MIVFHLIELLKNNGRLPRP-----DGCPDEIYMIMTECWNNNVNQRPSFRDL 300 >5U6B-A nrPDB Length = 307 Score = 181 bits (459), Expect = 3e-46, Method: Composition-based stats. Identities = 57/296 (19%), Positives = 104/296 (35%), Gaps = 44/296 (14%) Query: 8 PVAEIGVGAYGTVYKARDPHSG--HFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 +G G +G V + + VA+K++++ + E ++ Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSEL---EDFLSEAVCMKE--- 80 Query: 66 FEHPNVVRLMDVC--ATSRTDREIKVTLVFEHVDQDLRTYLDKAP----PPGLPAETIKD 119 F+HPNV+RL+ VC + R V ++ DL ++L + P LP + + Sbjct: 81 FDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVK 140 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY---SYQMALTPVVV 176 M G+++L +HRDL N ++ +V +ADFGL++ Y + Sbjct: 141 FMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKM 200 Query: 177 TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPE 235 + + A E L Y + D+WS G E+ + + G ++ + L Sbjct: 201 PVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQP 260 Query: 236 DDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 D + L+ NP R S + Sbjct: 261 ADCLDGLYA--------------------------LMSRCWELNPQDRPSFTELRE 290 >4Y93-A nrPDB Length = 446 Score = 181 bits (459), Expect = 4e-46, Method: Composition-based stats. Identities = 50/232 (21%), Positives = 101/232 (43%), Gaps = 20/232 (8%) Query: 9 VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 + E+G G +G V + + VA+K ++ G + E ++ L H Sbjct: 193 LKELGTGQFGVVKYGKWRG-QYDVAIKMIK------EGSMSEDEFIEEAKVMMNLS---H 242 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 +V+L VC R + ++ E++ + L YL + + + ++ + Sbjct: 243 EKLVQLYGVCTKQRP-----IFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDVCEA 296 Query: 128 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY--SYQMALTPVVVTLWYRAPEV 185 +++L + +HRDL N LV G VK++DFG+ R + T + + +PEV Sbjct: 297 MEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEV 356 Query: 186 LLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPED 236 L+ S +++ D+W+ G + E++ K + + ++ I + LP Sbjct: 357 LMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPH 408 >4LRM-A nrPDB Length = 334 Score = 180 bits (458), Expect = 5e-46, Method: Composition-based stats. Identities = 54/286 (18%), Positives = 108/286 (37%), Gaps = 16/286 (5%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + + ++ + +G GA+GTVYK G V + + E ++ Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 75 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 ++ +P+V RL+ +C TS V L+ + + + + ++ + + Sbjct: 76 ASVDNPGNPHVCRLLGICLTST------VQLITQLMPFGCLLDYVREHKDNIGSQYLLNW 129 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV---T 177 Q +G+++L +VHRDL N+LV + VK+ DFGLA++ + Sbjct: 130 CVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVP 189 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPED 236 + + A E +L Y D+WS G E+ + G ++ + LP Sbjct: 190 IKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPP 249 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHK 282 ++ + P+ E + +M +P + Sbjct: 250 IC----TIDVYMIMVKCWMIDADSRPKFRELIIEF-SKM-ARDPQR 289 >1U54-B nrPDB Length = 291 Score = 180 bits (458), Expect = 5e-46, Method: Composition-based stats. Identities = 64/252 (25%), Positives = 103/252 (40%), Gaps = 22/252 (8%) Query: 1 MATSRYEPVAEIGVGAYGTVYKAR-DPHSGHFV--ALKSVRVPNGGGGGGGLPISTVREV 57 + + ++G G++G V + D SG V A+K ++ +REV Sbjct: 15 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMD--DFIREV 72 Query: 58 ALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAET 116 + L +H N++RL V T + +V E L L K L T Sbjct: 73 NAMHSL---DHRNLIRLYGVVLTP------PMKMVTELAPLGSLLDRLRKHQGHFL-LGT 122 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALT 172 + Q G+ +L + +HRDL N+L+ + VK+ DFGL R + + Sbjct: 123 LSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQE 182 Query: 173 PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKI-FDLI 230 V + APE L T++ D W G EMF + + G + + L KI + Sbjct: 183 HRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGE 242 Query: 231 GLPPEDDWPRDV 242 LP +D P+D+ Sbjct: 243 RLPRPEDCPQDI 254 >3G0E-A nrPDB Length = 336 Score = 180 bits (457), Expect = 6e-46, Method: Composition-based stats. Identities = 61/315 (19%), Positives = 108/315 (34%), Gaps = 64/315 (20%) Query: 4 SRYEPVAEIGVGAYGTVYKA-----RDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVA 58 +R +G GA+G V +A + VA+K ++ + + E+ Sbjct: 46 NRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLK----PSAHLTEREALMSELK 101 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETI 117 +L L H N+V L+ C ++ E+ DL +L + + ++T Sbjct: 102 VLSYLG--NHMNIVNLLGACTIGGPT-----LVITEYCCYGDLLNFLRRKRDSFICSKTS 154 Query: 118 KDLM----------------RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGL 161 +M Q +G+ FL + +HRDL NIL+T G K+ DFGL Sbjct: 155 PAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGL 214 Query: 162 ARIYSYQMAL---TPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGN 217 AR + + + APE + Y D+WS G E+F + G Sbjct: 215 ARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGM 274 Query: 218 S-EADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEML 276 ++ I + + + P ++ Sbjct: 275 PVDSKFYKMIKEGFRMLSPEHAP--------------------------AEMYDIMKTCW 308 Query: 277 TFNPHKRISAFRALQ 291 +P KR + + +Q Sbjct: 309 DADPLKRPTFKQIVQ 323 >3OMV-A nrPDB Length = 307 Score = 180 bits (457), Expect = 7e-46, Method: Composition-based stats. Identities = 71/290 (24%), Positives = 122/290 (42%), Gaps = 38/290 (13%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 IG G++GTVYK + VA+K ++V + + EVA+LR+ H N Sbjct: 43 RIGSGSFGTVYKGKWHGD---VAVKILKVVDPTPEQFQ---AFRNEVAVLRK---TRHVN 93 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 ++ M + +V + + + D+ RQ +G+D+ Sbjct: 94 ILLFMGYMTKDN------LAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDY 147 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARI---YSYQMALTPVVVTLWYRAPEVLL 187 LHA I+HRD+K NI + G TVK+ DFGLA + +S + ++ + APEV+ Sbjct: 148 LHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIR 207 Query: 188 ---QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQ-LGKIFDLIGLPPEDDWPRDVS 243 + ++ D++S G + E+ + + + DQ + + P D+S Sbjct: 208 MQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASP-------DLS 260 Query: 244 LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHS 293 P R V V +++E L ++L S+ LQHS Sbjct: 261 KLYKNCPKAMKRLVADCVKKVKEE-RPLFPQIL--------SSIELLQHS 301 >3ZZW-A nrPDB Length = 289 Score = 180 bits (456), Expect = 8e-46, Method: Composition-based stats. Identities = 71/277 (25%), Positives = 113/277 (40%), Gaps = 40/277 (14%) Query: 10 AEIGVGAYGTVYKARDP-----HSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 E+G +G VYK VA+K+++ G R A+LR Sbjct: 15 EELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLK-----DKAEGPLREEFRHEAMLR--A 67 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYL--------------DKAPP 109 +HPNVV L+ V + ++++F + DL +L D+ Sbjct: 68 RLQHPNVVCLLGVVTKDQP-----LSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVK 122 Query: 110 PGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY---S 166 L L+ Q G+++L ++ +VH+DL N+LV VK++D GL R Sbjct: 123 SALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAAD 182 Query: 167 YQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGK 225 Y L ++ + + APE ++ ++ D+WS G + E+F +CG S D + Sbjct: 183 YYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEM 242 Query: 226 IFDLIGLPPEDDWPRDVSL----PRGAFPPRGPRPVQ 258 I + LP DD P V FP R PR Sbjct: 243 IRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKD 279 >4XI2-A nrPDB Length = 446 Score = 180 bits (456), Expect = 8e-46, Method: Composition-based stats. Identities = 53/229 (23%), Positives = 101/229 (44%), Gaps = 22/229 (9%) Query: 9 VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 + E+G G +G V + + VA+K +R G + E ++ L H Sbjct: 192 LKELGTGQFGVVKYGKWRG-QYDVAIKMIR------EGSMSEDEFIEEAKVMMNLS---H 241 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 +V+L VC R + ++ E++ + L YL + + + ++ + Sbjct: 242 EKLVQLYGVCTKQRP-----IFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDVCEA 295 Query: 128 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTL---WYRAPE 184 +++L + +HRDL N LV G VK++DFGL+R Y T V + + PE Sbjct: 296 MEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSR-YVLDDEYTSSVGSKFPVRWSPPE 354 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGL 232 VL+ S +++ D+W+ G + E++ K + + ++ I + L Sbjct: 355 VLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRL 403 >5AMN-A nrPDB Length = 299 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 61/289 (21%), Positives = 110/289 (38%), Gaps = 35/289 (12%) Query: 8 PVAEIGVGAYGTVYKARDPHSG-----HFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 +G G +G V KA H VA+K ++ L ++ Sbjct: 27 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDL-------LSEFNV 79 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPG--------LP 113 L+ HP+V++L C+ ++ + L+ E+ LR +L ++ G L Sbjct: 80 LKQVNHPHVIKLYGACS-----QDGPLLLIVEYAKYGSLRGFLRESRKVGPGYPDERALT 134 Query: 114 AETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR---IYSYQMA 170 + Q +G+ +L +VHRDL NILV G +K++DFGL+R + Sbjct: 135 MGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVK 194 Query: 171 LTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDL 229 + + + + A E L Y T D+WS G + E+ + G ++F+L Sbjct: 195 RSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPE----RLFNL 250 Query: 230 IGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTF 278 + + P + S + + P + L +M+ Sbjct: 251 LKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL-EKMMVK 298 >6E4F-A nrPDB Length = 290 Score = 178 bits (453), Expect = 2e-45, Method: Composition-based stats. Identities = 52/229 (22%), Positives = 101/229 (44%), Gaps = 22/229 (9%) Query: 9 VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 + E+G G +G V + + VA+K ++ G + E ++ L H Sbjct: 36 LKELGTGQFGVVKYGKWRG-QYDVAIKMIK------EGSMSEDEFIEEAKVMMNLS---H 85 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 +V+L VC R + ++ E++ + L YL + + + ++ + Sbjct: 86 EKLVQLYGVCTKQRP-----IFIITEYMANGCLLNYLREMRHR-FQTQQLLEMCKDVCEA 139 Query: 128 LDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTL---WYRAPE 184 +++L + +HRDL N LV G VK++DFGL+R Y T V + + PE Sbjct: 140 MEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSR-YVLDDEYTSSVGSKFPVRWSPPE 198 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGL 232 VL+ S +++ D+W+ G + E++ K + + ++ I + L Sbjct: 199 VLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRL 247 >4OW8-A nrPDB Length = 283 Score = 178 bits (451), Expect = 3e-45, Method: Composition-based stats. Identities = 71/284 (25%), Positives = 105/284 (36%), Gaps = 36/284 (12%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + RY I G G V++A D G VA+K ++ P R A R Sbjct: 10 SGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSD-----PEFIERFRAEART 64 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLM 121 HP + + D + LV E V+ + L + L + L D++ Sbjct: 65 TAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDML 122 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS--YQMALTPVVVTLW 179 Q R L HA +VHRD+KP NIL+T G VK+ DFG+A+ V+ T Sbjct: 123 EQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQ 182 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 Y APE L + D++S+G + E K F G+ K Sbjct: 183 YIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMK-------------- 228 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKR 283 P + P++ + +L+ L NP R Sbjct: 229 ------------HIKEPPPPLPPDLPPNVRELIEITLVKNPAMR 260 >4X3F-A nrPDB Length = 337 Score = 178 bits (451), Expect = 3e-45, Method: Composition-based stats. Identities = 71/284 (25%), Positives = 105/284 (36%), Gaps = 36/284 (12%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + RY I G G V++A D G VA+K ++ P R A R Sbjct: 11 SGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSD-----PEFIERFRAEART 65 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLM 121 HP + + D + LV E V+ + L + L + L D++ Sbjct: 66 TAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDML 123 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS--YQMALTPVVVTLW 179 Q R L HA +VHRD+KP NIL+T G VK+ DFG+A+ V+ T Sbjct: 124 EQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQ 183 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 Y APE L + D++S+G + E K F G+ K Sbjct: 184 YIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMK-------------- 229 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKR 283 P + P++ + +L+ L NP R Sbjct: 230 ------------HIKEPPPPLPPDLPPNVRELIEITLVKNPAMR 261 >4C59-A nrPDB Length = 340 Score = 178 bits (451), Expect = 3e-45, Method: Composition-based stats. Identities = 72/307 (23%), Positives = 119/307 (38%), Gaps = 58/307 (18%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 R + G + VY+A+D SG ALK + ++EV +++L Sbjct: 28 RLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRA-----IIQEVCFMKKLS 82 Query: 65 AFEHPNVVRLMDVCATSRTDREI---KVTLVFEHVDQDLRTYLDKAPPPG-LPAETIKDL 120 HPN+V+ + + + + + L+ E L +L K G L +T+ + Sbjct: 83 G--HPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGPLSCDTVLKI 140 Query: 121 MRQFLRGLDFLHANC--IVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALT------ 172 Q R + +H I+HRDLK EN+L+++ GT+KL DFG A S+ + Sbjct: 141 FYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQRR 200 Query: 173 -------PVVVTLWYRAPEVL-LQSTY--ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQ 222 T YR PE++ L S + D+W++GCI + R+ F + + Sbjct: 201 ALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQHPF---EDGAK 257 Query: 223 LGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHK 282 L + +PP D L+ ML NP + Sbjct: 258 LRIVNGKYSIPPHDTQYTVFHS--------------------------LIRAMLQVNPEE 291 Query: 283 RISAFRA 289 R+S Sbjct: 292 RLSIAEV 298 >6B2Q-A nrPDB Length = 317 Score = 178 bits (451), Expect = 3e-45, Method: Composition-based stats. Identities = 71/284 (25%), Positives = 105/284 (36%), Gaps = 36/284 (12%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + RY I G G V++A D G VA+K ++ P R A R Sbjct: 31 SGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSD-----PEFIERFRAEART 85 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLM 121 HP + + D + LV E V+ + L + L + L D++ Sbjct: 86 TAMLNHPGIASVHDYGESQMNGEGRTAYLVMELVNGEPLNSVLKRTGR--LSLRHALDML 143 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS--YQMALTPVVVTLW 179 Q R L HA +VHRD+KP NIL+T G VK+ DFG+A+ V+ T Sbjct: 144 EQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQ 203 Query: 180 YRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 Y APE L + D++S+G + E K F G+ K Sbjct: 204 YIAPEQALGHDASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMK-------------- 249 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKR 283 P + P++ + +L+ L NP R Sbjct: 250 ------------HIKEPPPPLPPDLPPNVRELIEITLVKNPAMR 281 >5GRN-A nrPDB Length = 356 Score = 177 bits (450), Expect = 4e-45, Method: Composition-based stats. Identities = 66/313 (21%), Positives = 106/313 (33%), Gaps = 72/313 (23%) Query: 8 PVAEIGVGAYGTVYKARDPHSGH-----FVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 +G GA+G V + VA+K ++ L + E+ ++ Sbjct: 50 LGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQAL----MSELKIMTH 105 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPP------------ 109 L H N+V L+ C S + ++ E+ DL YL K Sbjct: 106 LGP--HLNIVNLLGACTKSGP-----IYIITEYCFYGDLVNYLHKNRDSFLSHKKKSMLD 158 Query: 110 ------------PGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLA 157 GL + Q RG++FL + VHRDL N+L+ G VK+ Sbjct: 159 SEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKIC 218 Query: 158 DFGLARIY---SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPL 213 DFGLAR S ++ + + + APE + + Y T D+WS G + E+F Sbjct: 219 DFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTP 278 Query: 214 FCGNSEADQ-LGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLL 272 + G KI + D +++ Sbjct: 279 YPGMMVDSTFYNKIKSGYRMAKPDH--------------------------ATSEVYEIM 312 Query: 273 LEMLTFNPHKRIS 285 ++ P KR S Sbjct: 313 VKCWNSEPEKRPS 325 >5GNK-A nrPDB Length = 297 Score = 177 bits (449), Expect = 5e-45, Method: Composition-based stats. Identities = 54/286 (18%), Positives = 108/286 (37%), Gaps = 19/286 (6%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + + ++ + +G GA+GTVYK G V + + E ++ Sbjct: 16 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 75 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 + ++P+V RL+ +C TS V L+ + + + + ++ + + Sbjct: 76 ---ASVDNPHVCRLLGICLTST------VQLIMQLMPFGCLLDYVREHKDNIGSQYLLNW 126 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV---T 177 Q +G+++L +VHRDL N+LV + VK+ DFGLA++ + Sbjct: 127 CVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVP 186 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPED 236 + + A E +L Y D+WS G E+ + G ++ + LP Sbjct: 187 IKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPP 246 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHK 282 ++ + P+ E + +M +P + Sbjct: 247 IC----TIDVYMIMVKCWMIDADSRPKFRELIIEF-SKM-ARDPQR 286 >5HIE-A nrPDB Length = 302 Score = 177 bits (448), Expect = 7e-45, Method: Composition-based stats. Identities = 63/303 (20%), Positives = 118/303 (38%), Gaps = 54/303 (17%) Query: 2 ATSRYEP-------VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTV 54 ++ +E IG G++GTVYK + VA+K + + Sbjct: 27 SSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKML--------TPQQLQAFK 75 Query: 55 REVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPA 114 EV +LR+ H N++ M + + +V + + + Sbjct: 76 NEVGVLRK---TRHVNILLFMGYSTKPQ------LAIVTQWCEGSSLYHHLHIIETKFEM 126 Query: 115 ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI---YSYQMAL 171 + D+ RQ +G+D+LHA I+HRDLK NI + TVK+ DFGLA + +S Sbjct: 127 IKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQF 186 Query: 172 TPVVVTLWYRAPEVLL---QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD 228 + ++ + APEV+ ++ Y+ D+++ G + E+ + + + DQ+ + Sbjct: 187 EQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVG 246 Query: 229 LIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFR 288 L P+ + V ++ +L+ E L +R + Sbjct: 247 RGYLSPD---------------------LSKVRSNCPKAMKRLMAECLKKKRDERPLFPQ 285 Query: 289 ALQ 291 L Sbjct: 286 ILA 288 >3I81-A nrPDB Length = 315 Score = 177 bits (448), Expect = 8e-45, Method: Composition-based stats. Identities = 65/307 (21%), Positives = 112/307 (36%), Gaps = 56/307 (18%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDP-----HSGHFVALKSVRVPNGGGGGGGLPISTVR 55 +A + E+G G++G VY+ VA+K+V I + Sbjct: 15 VAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN----EAASMRERIEFLN 70 Query: 56 EVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPA 114 E ++++ F +VVRL+ V + + ++ E + DL++YL P Sbjct: 71 EASVMKE---FNCHHVVRLLGVVSQGQPT-----LVIMELMTRGDLKSYLRSLRPEMENN 122 Query: 115 ETIK--------DLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IY 165 + + + G+ +L+AN VHRDL N +V TVK+ DFG+ R IY Sbjct: 123 PVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIY 182 Query: 166 SYQMALTPVVV--TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQ 222 + + +PE L + T D+WS G + E+ + + G S Sbjct: 183 ETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQV 242 Query: 223 LGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHK 282 L + + L D+ P + +L+ +NP Sbjct: 243 LRFVMEGGLLDKPDNCPDML--------------------------FELMRMCWQYNPKM 276 Query: 283 RISAFRA 289 R S Sbjct: 277 RPSFLEI 283 >3LZB-A nrPDB Length = 327 Score = 176 bits (447), Expect = 9e-45, Method: Composition-based stats. Identities = 54/286 (18%), Positives = 108/286 (37%), Gaps = 19/286 (6%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + + ++ + +G GA+GTVYK G V + + E ++ Sbjct: 12 LKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVM 71 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 + ++P+V RL+ +C TS V L+ + + + + ++ + + Sbjct: 72 ---ASVDNPHVCRLLGICLTST------VQLITQLMPFGCLLDYVREHKDNIGSQYLLNW 122 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV---T 177 Q +G+++L +VHRDL N+LV + VK+ DFGLA++ + Sbjct: 123 CVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVP 182 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPED 236 + + A E +L Y D+WS G E+ + G ++ + LP Sbjct: 183 IKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPP 242 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHK 282 ++ + P+ E + +M +P + Sbjct: 243 IC----TIDVYMIMRKCWMIDADSRPKFRELIIEF-SKM-ARDPQR 282 >5U6C-A nrPDB Length = 315 Score = 176 bits (447), Expect = 9e-45, Method: Composition-based stats. Identities = 57/290 (19%), Positives = 106/290 (36%), Gaps = 44/290 (15%) Query: 8 PVAEIGVGAYGTVYKARDPH---SGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 +G G +G+V + + VA+K++++ N + E A ++ Sbjct: 40 LGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREI---EEFLSEAACMK--- 93 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLD----KAPPPGLPAETIKD 119 F HPNV+RL+ VC + K ++ + DL TYL + P +P +T+ Sbjct: 94 DFSHPNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLK 153 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY---SYQMALTPVVV 176 M G+++L +HRDL N ++ TV +ADFGL++ Y + Sbjct: 154 FMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKM 213 Query: 177 TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPE 235 + + A E L Y + D+W+ G E+ + G + + L Sbjct: 214 PVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQP 273 Query: 236 DDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 +D + +++ +P R + Sbjct: 274 EDCL--------------------------DELYEIMYSCWRTDPLDRPT 297 >5O0Y-A nrPDB Length = 579 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 65/299 (21%), Positives = 108/299 (36%), Gaps = 50/299 (16%) Query: 17 YGTVYKARDPHSGHFVALKS--VRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRL 74 + VYKA D +VA+K + RE + + L +HP +V+L Sbjct: 297 FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKEL---DHPRIVKL 353 Query: 75 MDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHAN 134 D + V E+ + + + K + + + ++ Q + L +L+ Sbjct: 354 YDYFSLDT----DSFCTVLEYCEGNDLDFYLKQHKL-MSEKEARSIIMQIVNALKYLNEI 408 Query: 135 C--IVHRDLKPENILVTSG---GTVKLADFGLARIYSYQ--------MALTPVVVTLWYR 181 I+H DLKP NIL+ +G G +K+ DFGL++I + T WY Sbjct: 409 KPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYL 468 Query: 182 APEVLLQS----TYATPVDMWSVGCIFAEMFRRKPLF-CGNSEADQLGKIFDLIGLPPED 236 PE + + VD+WSVG IF + + F S+ D L + Sbjct: 469 PPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQE----------- 517 Query: 237 DWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 + FPP+ P + + L + RI + YL Sbjct: 518 --NTILKATEVQFPPK---------PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 565 >3PP0-A nrPDB Length = 338 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 61/281 (21%), Positives = 99/281 (35%), Gaps = 24/281 (8%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFV----ALKSVRVPNGGGGGGGLPISTVRE 56 + + V +G GA+GTVYK G V A+K +R + E Sbjct: 14 LKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLR----ENTSPKANKEILDE 69 Query: 57 VALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAET 116 ++ P V RL+ +C TS V LV + + + L ++ Sbjct: 70 AYVM---AGVGSPYVSRLLGICLTST------VQLVTQLMPYGCLLDHVRENRGRLGSQD 120 Query: 117 IKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVV 176 + + Q +G+ +L +VHRDL N+LV S VK+ DFGLAR+ Sbjct: 121 LLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADG 180 Query: 177 ---TLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGL 232 + + A E +L+ + D+WS G E+ + G + + L Sbjct: 181 GKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERL 240 Query: 233 PPEDDWPRDVSL---PRGAFPPRGPRPVQSVVPEMEESGAQ 270 P DV + + +V E Sbjct: 241 PQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARD 281 >6CTH-A nrPDB Length = 309 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 61/240 (25%), Positives = 110/240 (45%), Gaps = 24/240 (10%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 TS + ++G G +G+VY+ S ++A+K V + G EV ++ Sbjct: 13 VTSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYAS-----EVKIIS 67 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDL 120 RL H N+V+L+ C ++ LV+E + + L +++ K L E + Sbjct: 68 RLR---HKNLVKLIGWC-----HERGELMLVYEFMANGSLDSHIFKGKSL-LTWEVRYRI 118 Query: 121 MRQFLRGLDFLHA---NCIVHRDLKPENILVTSGGTVKLADFGLARIYSY--QMALTPVV 175 ++ L +LH +C++HRD+K NI++ S KL DFGLAR+ + + T + Sbjct: 119 VKDLASALLYLHEEGDHCVLHRDIKTSNIMLDSSFNAKLGDFGLARLVDHAKGLKKTLLA 178 Query: 176 VTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRR----KPLFCGNSEADQLGKIFDLIG 231 T+ Y APE L + D++S G + E+ +P F + + +++ G Sbjct: 179 GTVGYMAPECLSSGKASKESDVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVWESYG 238 >1U59-A nrPDB Length = 287 Score = 175 bits (445), Expect = 1e-44, Method: Composition-based stats. Identities = 53/239 (22%), Positives = 96/239 (40%), Gaps = 20/239 (8%) Query: 11 EIGVGAYGTVYKA--RDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 E+G G +G+V + R VA+K ++ G +RE ++ +L+ Sbjct: 17 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLK----QGTEKADTEEMMREAQIMHQLDN--- 69 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 P +VRL+ VC + LV E +P + +L+ Q G+ Sbjct: 70 PYIVRLIGVCQAEA------LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGM 123 Query: 129 DFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALTPVVVTLWYRAPE 184 +L VHRDL N+L+ + K++DFGL++ SY A + L + APE Sbjct: 124 KYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE 183 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 + +++ D+WS G E + + + + I + + P ++ Sbjct: 184 CINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPEL 242 >2OZO-A nrPDB Length = 613 Score = 175 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 52/239 (21%), Positives = 96/239 (40%), Gaps = 20/239 (8%) Query: 11 EIGVGAYGTVYKA--RDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 E+G G +G+V + R VA+K ++ G +RE ++ +L+ Sbjct: 343 ELGCGNFGSVRQGVYRMRKKQIDVAIKVLK----QGTEKADTEEMMREAQIMHQLDN--- 395 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 P +VRL+ VC + LV E +P + +L+ Q G+ Sbjct: 396 PYIVRLIGVCQAEA------LMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGM 449 Query: 129 DFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALTPVVVTLWYRAPE 184 +L VHR+L N+L+ + K++DFGL++ SY A + L + APE Sbjct: 450 KYLEEKNFVHRNLAARNVLLVNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPE 509 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 242 + +++ D+WS G E + + + + I + + P ++ Sbjct: 510 CINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPEL 568 >4IDT-A nrPDB Length = 356 Score = 175 bits (444), Expect = 2e-44, Method: Composition-based stats. Identities = 67/312 (21%), Positives = 105/312 (33%), Gaps = 64/312 (20%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +G G++G V++ D +G A+K VR+ L P Sbjct: 81 RLGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFR-------------AEELMACAGLTSPR 127 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 +V L V + E ++ L K LP + + Q L GL++ Sbjct: 128 IVPLYGAVREG-----PWVNIFMELLEGGSLGQLVKEQGC-LPEDRALYYLGQALEGLEY 181 Query: 131 LHANCIVHRDLKPENILVTSGG-TVKLADFGLARIYSYQMALTPVV------VTLWYRAP 183 LH+ I+H D+K +N+L++S G L DFG A ++ T + AP Sbjct: 182 LHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAP 241 Query: 184 EVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 EV+L + VD+WS C+ M W + Sbjct: 242 EVVLGRSCDAKVDVWSSCCMMLHMLNGCHP------------------------WTQFFR 277 Query: 244 LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA-------------L 290 P P PV+ + P AQ + E L P R+SA L Sbjct: 278 GPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGL 337 Query: 291 QHSYLHKDEGNP 302 + + + P Sbjct: 338 KSPW-RGEYKEP 348 >2BUJ-A nrPDB Length = 317 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 77/314 (24%), Positives = 120/314 (38%), Gaps = 53/314 (16%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + Y + ++G G + V H GHF ALK + RE + Sbjct: 26 IDNKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDR-----EEAQREADMH 80 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPG--LPAETIK 118 R F HPN++RL+ C R + L+ L +++ G L + I Sbjct: 81 R---LFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQIL 137 Query: 119 DLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGL----------ARIYSYQ 168 L+ RGL+ +HA HRDLKP NIL+ G L D G +R Sbjct: 138 WLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTL 197 Query: 169 MALTPVVVTLWYRAPEVLLQSTY---ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGK 225 T+ YRAPE+ ++ D+WS+GC+ M + + D + + Sbjct: 198 QDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPY------DMVFQ 251 Query: 226 IFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKR-- 283 D + L ++ +S+P+ P + QLL M+T +PH+R Sbjct: 252 KGDSVALAVQNQ----LSIPQS--------------PRHSSALWQLLNSMMTVDPHQRPH 293 Query: 284 ----ISAFRALQHS 293 +S ALQ Sbjct: 294 IPLLLSQLEALQPP 307 >4X7Q-B nrPDB Length = 312 Score = 174 bits (442), Expect = 3e-44, Method: Composition-based stats. Identities = 75/298 (25%), Positives = 108/298 (36%), Gaps = 47/298 (15%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSV-RVPNGGGGGGGLPISTVREVALLRRL 63 Y +G G +GTV+ VA+K + R G ++ EVALL ++ Sbjct: 32 EYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKV 91 Query: 64 -EAFEHPNVVRLMDVCATSRTDREIKVTLVFE--HVDQDLRTYLDKAPPPGLPAETIKDL 120 HP V+RL+D T LV E QDL Y+ + P L + Sbjct: 92 GAGGGHPGVIRLLDWFETQEG-----FMLVLERPLPAQDLFDYITEKGP--LGEGPSRCF 144 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALTPVVVTLW 179 Q + + H+ +VHRD+K ENIL+ G KL DFG + + T T Sbjct: 145 FGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDE-PYTDFDGTRV 203 Query: 180 YRAPEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y PE + + Y A P +WS+G + +M F + E L E + Sbjct: 204 YSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEI-----------LEAELHF 252 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 P VS A L+ L P R S L ++ Sbjct: 253 PAHVSPDCCA----------------------LIRRCLAPKPSSRPSLEEILLDPWMQ 288 >4YFF-A nrPDB Length = 311 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 68/282 (24%), Positives = 107/282 (37%), Gaps = 22/282 (7%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + S E IG G++G VYK R VA+K R REV++L Sbjct: 39 LQLSEIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVD--MFCREVSIL 94 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 +L HP V++ + C + +V +++ L L ++ + Sbjct: 95 CQL---NHPCVIQFVGACLND----PSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLII 147 Query: 121 MRQFLRGLDFLH--ANCIVHRDLKPENILVTSGGTVKLADFGLARIYS--YQMALTPVVV 176 +G+++LH I+HRDL NIL+ G +ADFG +R + +T Sbjct: 148 AVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPG 207 Query: 177 TLWYRAPEVLLQS-TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI-FDLIGLPP 234 L + APEV Q Y D++S E+ + F A + + I P Sbjct: 208 NLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPI 267 Query: 235 EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEML 276 P+ +S + RG PE E +L E L Sbjct: 268 GYSIPKPIS----SLLIRGWNACPEGRPEFSEVVMKL-EECL 304 >5FM2-A nrPDB Length = 355 Score = 174 bits (441), Expect = 4e-44, Method: Composition-based stats. Identities = 61/303 (20%), Positives = 110/303 (36%), Gaps = 49/303 (16%) Query: 8 PVAEIGVGAYGTVYKARDPHSG-----HFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 +G G +G V KA H VA+K ++ L ++ Sbjct: 68 LGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDL-------LSEFNV 120 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPG---------- 111 L+ HP+V++L C+ ++ + L+ E+ LR +L ++ G Sbjct: 121 LKQVNHPHVIKLYGACS-----QDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSR 175 Query: 112 ------------LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADF 159 L + Q +G+ +L +VHRDL NILV G +K++DF Sbjct: 176 NSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDF 235 Query: 160 GLAR---IYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFC 215 GL+R + + + + + A E L Y T D+WS G + E+ + Sbjct: 236 GLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYP 295 Query: 216 GNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEM 275 G ++F+L+ + P + S + + P + L +M Sbjct: 296 GIPPE----RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL-EKM 350 Query: 276 LTF 278 + Sbjct: 351 MVK 353 >6J5U-C nrPDB Length = 426 Score = 173 bits (440), Expect = 6e-44, Method: Composition-based stats. Identities = 71/305 (23%), Positives = 113/305 (37%), Gaps = 39/305 (12%) Query: 2 ATSRYEPVAEIGVGAYGTVYK---------ARDPHSGHFVALKSVRVPNGGGGGGGLPIS 52 AT + +G G +G V+K A P SG VA+K ++ G Sbjct: 82 ATKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLK-----PEGFQGHKE 136 Query: 53 TVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPG 111 + EV L +L HPN+V L+ CA LV+E + L +L + Sbjct: 137 WLTEVNYLGQLS---HPNLVLLVGYCAEGENR-----LLVYEFMPKGSLENHLFRRGAQP 188 Query: 112 LPAETIKDLMRQFLRGLDFLHANC--IVHRDLKPENILVTSGGTVKLADFGLAR---IYS 166 L + +GL FLH +++RD K NIL+ + KL+DFGLA+ Sbjct: 189 LTWAIRMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFNAKLSDFGLAKAGPTGD 248 Query: 167 YQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI 226 T V+ T Y APE + D++S G + E+ + ++ ++ + Sbjct: 249 NTHVSTKVIGTHGYAAPEYVATGRLTAKSDVYSFGVVLLELISGRRAMDNSNGGNEYSLV 308 Query: 227 FDLIGLPPEDDWPR-DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 DW + R F + + + A L L+ L + R Sbjct: 309 ----------DWATPYLGDKRKLFRIMDTKLGGQYPQKGAFTAANLALQCLNPDAKLRPK 358 Query: 286 AFRAL 290 L Sbjct: 359 MSEVL 363 >3PLS-A nrPDB Length = 298 Score = 172 bits (437), Expect = 1e-43, Method: Composition-based stats. Identities = 61/285 (21%), Positives = 100/285 (35%), Gaps = 46/285 (16%) Query: 10 AEIGVGAYGTVYKARDPHSGH---FVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF 66 IG G +G VY A+KS+ + +RE L+R Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQV----EAFLREGLLMR---GL 79 Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLR 126 HPNV+ L+ + + L+ DL ++ ++P + + Q R Sbjct: 80 NHPNVLALIGIMLPP---EGLPHVLLPYMCHGDLLQFI-RSPQRNPTVKDLISFGLQVAR 135 Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLA-----RIYSYQMALTPVVVTLWYR 181 G+++L VHRDL N ++ TVK+ADFGLA R Y + + + Sbjct: 136 GMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWT 195 Query: 182 APEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 A E L + T D+WS G + E+ P + D + LP + P Sbjct: 196 ALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCP- 254 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 +S Q++ + +P R + Sbjct: 255 -------------------------DSLYQVMQQCWEADPAVRPT 274 >5HLW-A nrPDB Length = 299 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 60/267 (22%), Positives = 98/267 (36%), Gaps = 26/267 (9%) Query: 10 AEIGVGAYGTVYKAR---DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF 66 IG G +G VY + A+KS+ G + ++ F Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGI-------IMKDF 78 Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFL 125 HPNV+ L+ +C S E +V ++ DLR ++ + + Q Sbjct: 79 SHPNVLSLLGICLRS----EGSPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVA 133 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM-----ALTPVVVTLWY 180 +G+ +L + VHRDL N ++ TVK+ADFGLAR + T + + + Sbjct: 134 KGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKW 193 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 A E L + T D+WS G + E+ P + + D + L + P Sbjct: 194 MALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCP 253 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEE 266 P + P + P E Sbjct: 254 D----PLYEVMLKCWHPKAEMRPSFSE 276 >3Q4U-A nrPDB Length = 301 Score = 172 bits (435), Expect = 2e-43, Method: Composition-based stats. Identities = 79/315 (25%), Positives = 117/315 (37%), Gaps = 62/315 (19%) Query: 8 PVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 + +G G YG V++ G VA+K S RE L + Sbjct: 12 LLECVGKGRYGEVWRG--SWQGENVAVKIF--------SSRDEKSWFRETELYNTV-MLR 60 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLR 126 H N++ + TSR ++ L+ + + L YL L + ++ Sbjct: 61 HENILGFIASDMTSR-HSSTQLWLITHYHEMGSLYDYLQ---LTTLDTVSCLRIVLSIAS 116 Query: 127 GLDFLH--------ANCIVHRDLKPENILVTSGGTVKLADFGLARIYSY-----QMALTP 173 GL LH I HRDLK +NILV G +AD GLA ++S + P Sbjct: 117 GLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNP 176 Query: 174 VVVTLWYRAPEVLLQ-------STYATPVDMWSVGCIFAEMFRR----------KPLFCG 216 V T Y APEVL + +Y VD+W+ G + E+ RR KP F Sbjct: 177 RVGTKRYMAPEVLDETIQVDCFDSY-KRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYD 235 Query: 217 NSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEML 276 D P +D + V + + R P + S A+L+ E Sbjct: 236 VVPND-----------PSFEDMRKVVCVDQ----QRPNIPNRWFSDPTLTSLAKLMKECW 280 Query: 277 TFNPHKRISAFRALQ 291 NP R++A R + Sbjct: 281 YQNPSARLTALRIKK 295 >5TUR-A nrPDB Length = 404 Score = 172 bits (435), Expect = 3e-43, Method: Composition-based stats. Identities = 66/299 (22%), Positives = 105/299 (35%), Gaps = 47/299 (15%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTV-REVALLRR 62 S+Y+ +G G +G+VY VA+K V G + V EV LL++ Sbjct: 127 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 186 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD--QDLRTYLDKAPPPGLPAETIKDL 120 + + V+RL+D R L+ E + QDL ++ + L E + Sbjct: 187 VSSGFS-GVIRLLDWFE-----RPDSFVLILERPEPVQDLFDFITERG--ALQEELARSF 238 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALTPVVVTLW 179 Q L + H ++HRD+K ENIL+ + G +KL DFG + T T Sbjct: 239 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRV 297 Query: 180 YRAPEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y PE + Y +WS+G + +M F + E Sbjct: 298 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------------------- 338 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 + RG R + L+ L P R + H ++ Sbjct: 339 -----IIRGQVFFRQ---------RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 383 >4Y83-A nrPDB Length = 332 Score = 171 bits (434), Expect = 3e-43, Method: Composition-based stats. Identities = 67/288 (23%), Positives = 109/288 (37%), Gaps = 43/288 (14%) Query: 14 VGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVR 73 GA+G VY A+D + +A K + V E+ F H N+ Sbjct: 83 RGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDV--------EIQAC-----FRHENIAE 129 Query: 74 LMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPG-LPAETIKDLMRQFLRGLDFLH 132 L T V L E + + L+K G + I + + L+GLDFLH Sbjct: 130 LYGAVLWGET-----VHLFMEAGEGG--SVLEKLESCGPMREFEIIWVTKHVLKGLDFLH 182 Query: 133 ANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL-TPVVVTLWYRAPEVLLQSTY 191 + ++H D+KP NI+ S V L DFGL+ + + + T Y +PEV+L + Sbjct: 183 SKKVIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGH 241 Query: 192 ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPP 251 +T D++S+G M P + +PR Sbjct: 242 STKADIYSLGATLIHMQTGTPPW--------------------VKRYPRSAYPSYLYIIH 281 Query: 252 RGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDE 299 + P++ + + +L+ L NP+ R A L+H L+ Sbjct: 282 KQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEALNPPR 329 >3C1X-A nrPDB Length = 373 Score = 171 bits (434), Expect = 3e-43, Method: Composition-based stats. Identities = 61/267 (22%), Positives = 98/267 (36%), Gaps = 26/267 (9%) Query: 10 AEIGVGAYGTVYKAR---DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF 66 IG G +G VY + A+KS+ G + ++ F Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGI-------IMKDF 147 Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFL 125 HPNV+ L+ +C S E +V ++ DLR ++ + + Q Sbjct: 148 SHPNVLSLLGICLRS----EGSPLVVLPYMKHGDLRNFIRNETHNP-TVKDLIGFGLQVA 202 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-----IYSYQMALTPVVVTLWY 180 +G+ FL + VHRDL N ++ TVK+ADFGLAR + T + + + Sbjct: 203 KGMKFLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEFDSVHNKTGAKLPVKW 262 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWP 239 A E L + T D+WS G + E+ P + + D + L + P Sbjct: 263 MALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCP 322 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEE 266 P + P + P E Sbjct: 323 D----PLYEVMLKCWHPKAEMRPSFSE 345 >4TPT-A nrPDB Length = 303 Score = 171 bits (434), Expect = 3e-43, Method: Composition-based stats. Identities = 53/222 (23%), Positives = 95/222 (42%), Gaps = 37/222 (16%) Query: 10 AEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHP 69 +G G +G K +G + +K + + + EV ++R L +HP Sbjct: 6 EVLGKGFFGQAIKVTHKATGKVMVMKEL-----IRCDEETQKTFLTEVKVMRSL---DHP 57 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 NV++ + V + K+ L+ E+++ L+ +L P P + + G+ Sbjct: 58 NVLKFIGVLYKDK-----KLNLLTEYIEGGTLKDFLRSMDP--FPWQQKVRFAKGIASGM 110 Query: 129 DFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY---------------------SY 167 +LH+ CI+HRDL N L+ TV +ADFGL+R+ + Sbjct: 111 AYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRAPMEKATTKKRTLRKND 170 Query: 168 QMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR 209 + VV ++ APE+L +Y VD++S G + E+ Sbjct: 171 RKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIG 212 >3BGP-A nrPDB Length = 333 Score = 170 bits (431), Expect = 6e-43, Method: Composition-based stats. Identities = 66/299 (22%), Positives = 105/299 (35%), Gaps = 47/299 (15%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTV-REVALLRR 62 S+Y+ +G G +G+VY VA+K V G + V EV LL++ Sbjct: 56 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 115 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD--QDLRTYLDKAPPPGLPAETIKDL 120 + + V+RL+D R L+ E + QDL ++ + L E + Sbjct: 116 VSSGFS-GVIRLLDWFE-----RPDSFVLILERPEPVQDLFDFITERG--ALQEELARSF 167 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALTPVVVTLW 179 Q L + H ++HRD+K ENIL+ + G +KL DFG + T T Sbjct: 168 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRV 226 Query: 180 YRAPEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y PE + Y +WS+G + +M F + E Sbjct: 227 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------------------- 267 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 + RG R + L+ L P R + H ++ Sbjct: 268 -----IIRGQVFFRQ---------RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 312 >5LPZ-A nrPDB Length = 332 Score = 169 bits (429), Expect = 1e-42, Method: Composition-based stats. Identities = 67/299 (22%), Positives = 116/299 (38%), Gaps = 33/299 (11%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 AT+ + + IG G +G VYKA G VA+K + +G G + A + Sbjct: 15 ATNGFHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDREFM--------AEME 65 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLD--KAPPPGLPAETIK 118 + +H N+V L+ C LV+E + L L K L T + Sbjct: 66 TIGKIKHRNLVPLLGYCKVGDER-----LLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRR 120 Query: 119 DLMRQFLRGLDFLHAN---CIVHRDLKPENILVTSGGTVKLADFGLARIY---SYQMALT 172 + RGL FLH N I+HRD+K N+L+ +++DFG+AR+ ++++ Sbjct: 121 KIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVS 180 Query: 173 PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGL 232 + T Y PE +T D++S G + E+ K D +L+G Sbjct: 181 TLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDN-----NLVGW 235 Query: 233 PPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 + R + P ++ ++ + A L +R + + + Sbjct: 236 VKQHAKLRISDVFDPELMKEDPALEIELLQHLKVAVACLDDRAW-----RRPTMVQVMA 289 >2QKW-B nrPDB Length = 321 Score = 169 bits (429), Expect = 1e-42, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 110/295 (37%), Gaps = 30/295 (10%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 AT+ ++ IG G +G VYK G VALK R P G Sbjct: 37 ATNNFDHKFLIGHGVFGKVYKGVLR-DGAKVALKR-RTPESSQGIEEFETEIE------- 87 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYL--DKAPPPGLPAETIK 118 L HP++V L+ C D ++ L++++++ +L+ +L P + E Sbjct: 88 TLSFCRHPHLVSLIGFC-----DERNEMILIYKYMENGNLKRHLYGSDLPTMSMSWEQRL 142 Query: 119 DLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR---IYSYQMALTPVV 175 ++ RGL +LH I+HRD+K NIL+ K+ DFG+++ T V Sbjct: 143 EICIGAARGLHYLHTRAIIHRDVKSINILLDENFVPKITDFGISKKGTELDQTHLSTVVK 202 Query: 176 VTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPE 235 TL Y PE ++ D++S G + E+ + + + + Sbjct: 203 GTLGYIDPEYFIKGRLTEKSDVYSFGVVLFEVLCARSAIVQSLPREMVNL---------- 252 Query: 236 DDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRAL 290 +W + P + PE ++ L + R S L Sbjct: 253 AEWAVESHNNGQLEQIVDPNLADKIRPESLRKFGDTAVKCLALSSEDRPSMGDVL 307 >4RC3-A nrPDB Length = 289 Score = 169 bits (429), Expect = 1e-42, Method: Composition-based stats. Identities = 66/299 (22%), Positives = 105/299 (35%), Gaps = 47/299 (15%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTV-REVALLRR 62 S+Y+ +G G +G+VY VA+K V G + V EV LL++ Sbjct: 12 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 71 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD--QDLRTYLDKAPPPGLPAETIKDL 120 + + V+RL+D R L+ E + QDL ++ + L E + Sbjct: 72 VSSGFS-GVIRLLDWFE-----RPDSFVLILERPEPVQDLFDFITERG--ALQEELARSF 123 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALTPVVVTLW 179 Q L + H ++HRD+K ENIL+ + G +KL DFG + T T Sbjct: 124 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRV 182 Query: 180 YRAPEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 Y PE + Y +WS+G + +M F + E Sbjct: 183 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------------------- 223 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 + RG R + L+ L P R + H ++ Sbjct: 224 -----IIRGQVFFRQ---------RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 268 >5UIU-A nrPDB Length = 323 Score = 168 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 65/289 (22%), Positives = 111/289 (38%), Gaps = 32/289 (11%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 ++G G +G VYK ++ VA+K + L +E+ ++ + +H N Sbjct: 54 KMGEGGFGVVYKGYVNNT--TVAVKKL-AAMVDITTEELKQQFDQEIKVMAKC---QHEN 107 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLD-KAPPPGLPAETIKDLMRQFLRGL 128 +V L+ + + LV+ ++ + L L P L + + G+ Sbjct: 108 LVELLGFSSDGDD-----LCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGI 162 Query: 129 DFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR---IYSYQMALTPVVVTLWYRAPEV 185 +FLH N +HRD+K NIL+ T K++DFGLAR ++ + + +V T Y APE Sbjct: 163 NFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEA 222 Query: 186 LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP 245 L D++S G + E+ P + E L + D Sbjct: 223 LRGEI-TPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLD---------IKEEIEDEEKT 272 Query: 246 RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAF---RALQ 291 + + S E S A + L +KR + LQ Sbjct: 273 IEDYIDKKMNDADSTSVEAMYSVA---SQCLHEKKNKRPDIKKVQQLLQ 318 >5LPV-A nrPDB Length = 296 Score = 168 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 67/299 (22%), Positives = 116/299 (38%), Gaps = 33/299 (11%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 AT+ + + IG G +G VYKA G VA+K + +G G + A + Sbjct: 15 ATNGFHNDSLIGSGGFGDVYKAILK-DGSAVAIKKLIHVSGQGDREFM--------AEME 65 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLD--KAPPPGLPAETIK 118 + +H N+V L+ C LV+E + L L K L T + Sbjct: 66 TIGKIKHRNLVPLLGYCKVGDER-----LLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRR 120 Query: 119 DLMRQFLRGLDFLHAN---CIVHRDLKPENILVTSGGTVKLADFGLARIY---SYQMALT 172 + RGL FLH N I+HRD+K N+L+ +++DFG+AR+ ++++ Sbjct: 121 KIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENLEARVSDFGMARLMSAMDTHLSVS 180 Query: 173 PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGL 232 + T Y PE +T D++S G + E+ K D +L+G Sbjct: 181 TLAGTPGYVPPEYYQSFRCSTKGDVYSYGVVLLELLTGKRPTDSPDFGDN-----NLVGW 235 Query: 233 PPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 + R + P ++ ++ + A L +R + + + Sbjct: 236 VKQHAKLRISDVFDPELMKEDPALEIELLQHLKVAVACLDDRAW-----RRPTMVQVMA 289 >3MY0-A nrPDB Length = 305 Score = 168 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 76/321 (23%), Positives = 112/321 (34%), Gaps = 52/321 (16%) Query: 8 PVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 V +G G YG V++ G VA+K + S RE + + Sbjct: 12 LVECVGKGRYGEVWRGLWH--GESVAVKIFSSRDEQ--------SWFRETEIYNTV-LLR 60 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLR 126 H N++ + TSR ++ L+ + + L +L + L L Sbjct: 61 HDNILGFIASDMTSRNSS-TQLWLITHYHEHGSLYDFLQRQT---LEPHLALRLAVSAAC 116 Query: 127 GLDFLH--------ANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL-----TP 173 GL LH I HRD K N+LV S +AD GLA ++S P Sbjct: 117 GLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSDYLDIGNNP 176 Query: 174 VVVTLWYRAPEVLLQSTYA------TPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIF 227 V T Y APEVL + D+W+ G + E+ RR + I Sbjct: 177 RVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRT----------IVNGIV 226 Query: 228 DLIGLPPEDDWPRDVSLPR-----GAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHK 282 + P D P D S P + + AQ++ E NP Sbjct: 227 EDYRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSA 286 Query: 283 RISAFRALQHSYLHKDEGNPE 303 R++A R + L K +PE Sbjct: 287 RLTALRIKK--TLQKISNSPE 305 >6HV0-A nrPDB Length = 416 Score = 168 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 85/310 (27%), Positives = 125/310 (40%), Gaps = 58/310 (18%) Query: 6 YEPVAEIGVGAYGT-VYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 + P +G GA GT VY+ VA+K + REV LLR Sbjct: 10 FCPKDVLGHGAEGTIVYRG--MFDNRDVAVKRILPECFSFAD--------REVQLLRE-- 57 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 + EHPNV+R C + + E L+ Y+++ L E I L++Q Sbjct: 58 SDEHPNVIRYF--CTEKDRQFQ---YIAIELCAATLQEYVEQKDFAHLGLEPI-TLLQQT 111 Query: 125 LRGLDFLHANCIVHRDLKPENILV---TSGGTVK--LADFGLARIYSYQMA----LTPVV 175 GL LH+ IVHRDLKP NIL+ + G +K ++DFGL + + + V Sbjct: 112 TSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVP 171 Query: 176 VTLWYRAPEVLLQSTY---ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGL 232 T + APE+L + VD++S GC+F + Sbjct: 172 GTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVIS----------------------- 208 Query: 233 PPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEES--GAQLLLEMLTFNPHKRISAFRAL 290 E P SL R A G + + PE E +L+ +M+ +P KR SA L Sbjct: 209 --EGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVL 266 Query: 291 QHSYLHKDEG 300 +H + E Sbjct: 267 KHPFFWSLEK 276 >2PMN-X nrPDB Length = 348 Score = 168 bits (425), Expect = 3e-42, Method: Composition-based stats. Identities = 66/312 (21%), Positives = 120/312 (38%), Gaps = 26/312 (8%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + Y + + G + + F ALK + S ++++ + Sbjct: 30 INDYRIIRTLNQGKFNKIILCEK--DNKFYALKK-YEKSLLEKKRDFTKSNNDKISIKSK 86 Query: 63 LEAFEHP-----NVVRLMDVCATSRTDREIKVTLVFEHVDQDL-------RTYLDKAPPP 110 + F++ ++ + +V +++E+++ D LDK Sbjct: 87 YDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLDKNYTC 146 Query: 111 GLPAETIKDLMRQFLRGLDFLH-ANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM 169 +P + IK +++ L ++H I HRD+KP NIL+ G VKL+DFG + Y Sbjct: 147 FIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKNGRVKLSDFGES-EYMVDK 205 Query: 170 ALTPVVVTLWYRAPEVL-LQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIF 227 + T + PE +S+Y VD+WS+G MF F S L ++F Sbjct: 206 KIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPF---SLKISLVELF 262 Query: 228 DLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAF 287 + I ++P D + P + + L L NP +RI++ Sbjct: 263 NNIRT-KNIEYPLDRN---HFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERITSE 318 Query: 288 RALQHSYLHKDE 299 AL+H +L Sbjct: 319 DALKHEWLADTN 330 >4FL3-A nrPDB Length = 635 Score = 167 bits (424), Expect = 4e-42, Method: Composition-based stats. Identities = 56/281 (19%), Positives = 106/281 (37%), Gaps = 44/281 (15%) Query: 10 AEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHP 69 E+G G +GTV K +V++ L + E ++++L ++P Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVK-TVAVKILKNEANDPALKDELLAEANVMQQL---DNP 430 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 +VR++ +C LV E + L YL + + + I +L+ Q G+ Sbjct: 431 YIVRMIGICEAES------WMLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQVSMGM 482 Query: 129 DFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALTPVVVTLWYRAPE 184 +L + VHRDL N+L+ + K++DFGL++ +Y A T + + APE Sbjct: 483 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 + +++ D+WS G + E F + + G ++ + + PR Sbjct: 543 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR--- 599 Query: 244 LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI 284 L+ T++ R Sbjct: 600 -----------------------EMYDLMNLCWTYDVENRP 617 >3MDY-A nrPDB Length = 337 Score = 167 bits (423), Expect = 6e-42, Method: Composition-based stats. Identities = 79/315 (25%), Positives = 115/315 (36%), Gaps = 52/315 (16%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + + V +IG G YG V+ + G VA+K S RE + + Sbjct: 36 AKQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEA--------SWFRETEIYQT 85 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLM 121 + H N++ + T ++ L+ ++ + L YL L A+++ L Sbjct: 86 V-LMRHENILGFIAA-DIKGTGSWTQLYLITDYHENGSLYDYLKS---TTLDAKSMLKLA 140 Query: 122 RQFLRGLDFLHAN--------CIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL-- 171 + GL LH I HRDLK +NILV GT +AD GLA + Sbjct: 141 YSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVD 200 Query: 172 ---TPVVVTLWYRAPEVLLQ-------STYATPVDMWSVGCIFAEMFRRKPLFCGNSEAD 221 V T Y PEVL + +Y DM+S G I E+ RR Sbjct: 201 IPPNTRVGTKRYMPPEVLDESLNRNHFQSY-IMADMYSFGLILWEVARRC---------- 249 Query: 222 QLGKIFDLIGLPPEDDWPRDVSLPR-----GAFPPRGPRPVQSVVPEMEESGAQLLLEML 276 G I + LP D P D S R P + E +L+ E Sbjct: 250 VSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECW 309 Query: 277 TFNPHKRISAFRALQ 291 NP R++A R + Sbjct: 310 AHNPASRLTALRVKK 324 >3QD2-B nrPDB Length = 332 Score = 167 bits (423), Expect = 6e-42, Method: Composition-based stats. Identities = 65/354 (18%), Positives = 126/354 (35%), Gaps = 102/354 (28%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 +EP+ +G G +G V++A++ A+K +R+PN +REV L +L Sbjct: 7 DFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELA----REKVMREVKALAKL- 61 Query: 65 AFEHPNVVRLMDVCATSRTDR--------------------------------------- 85 EHP +VR + + ++ Sbjct: 62 --EHPGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFS 119 Query: 86 -------------EIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETI-KDLMRQFLRGLDF 130 ++ + + + + +L+ ++++ + + Q ++F Sbjct: 120 TKNTVGQLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEF 179 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL-------------TPVVVT 177 LH+ ++HRDLKP NI T VK+ DFGL T V T Sbjct: 180 LHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGT 239 Query: 178 LWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 Y +PE + + Y+ VD++S+G I E+ + +++ +++ I D+ L Sbjct: 240 KLYMSPEQIHGNNYSHKVDIFSLGLILFELL-----YSFSTQMERVRIITDVRNL----- 289 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 + P P+ ML+ +P +R A ++ Sbjct: 290 --------------KFPLLFTQKYPQEHMMVQD----MLSPSPTERPEATDIIE 325 >5IKW-A nrPDB Length = 310 Score = 167 bits (422), Expect = 7e-42, Method: Composition-based stats. Identities = 72/297 (24%), Positives = 112/297 (37%), Gaps = 53/297 (17%) Query: 8 PVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 + G + TV+ R H G ALK + V N RE+ +++ L Sbjct: 18 LEESLAEGGFSTVFLVR-THGGIRCALKRMYVNNMPDLNV-----CKREITIMKELSG-- 69 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLR 126 H N+V +D S +D +V ++ E+ + ++K G + + Sbjct: 70 HKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCDTCE 129 Query: 127 GLDFLHANC--IVHRDLKPENILVTSGGTVKLADFGLA--RIYSYQMALTPVV------- 175 + LH I+HRDLK ENIL+ GG L DFG A + + Q VV Sbjct: 130 AVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKY 189 Query: 176 VTLWYRAPEVLL---QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGL 232 TL YRAPE++ T D+W++GC+ ++ F G S+ I D Sbjct: 190 TTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPF-GESQV----AICDGNFT 244 Query: 233 PPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 P++ R R + L+ ML +P R F+ Sbjct: 245 IPDN--------------SRYSRNIHC-----------LIRFMLEPDPEHRPDIFQV 276 >2WTK-B nrPDB Length = 373 Score = 167 bits (422), Expect = 7e-42, Method: Composition-based stats. Identities = 68/336 (20%), Positives = 110/336 (32%), Gaps = 50/336 (14%) Query: 6 YEPVAEIGVGAYG---TVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 YE + IG G + TV AR +G +V ++ + + L Sbjct: 11 YELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQ------GELHV 63 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLM 121 + F HPN+V ++ +V + + + G+ I ++ Sbjct: 64 SKLFNHPNIVPYRATFIADN-----ELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYIL 118 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADF--GLARIYSYQMALTP------ 173 + L+ LD++H VHR +K +IL++ G V L+ L+ I Q Sbjct: 119 QGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKY 178 Query: 174 VVVTLWYRAPEVLLQ--STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDL-- 229 V L + +PEVL Q Y D++SVG E+ F L + + Sbjct: 179 SVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTV 238 Query: 230 -----IGLPPEDDWPRDVSLPRGAF------------PPRGPRPVQSVVPEMEESGAQLL 272 P ++ S P G P + Sbjct: 239 PCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFV 298 Query: 273 LEMLTFNPHKRISAFRALQHSYLHK-----DEGNPE 303 + L NP R SA L HS+ + E PE Sbjct: 299 EQCLQRNPDARPSASTLLNHSFFKQIKRRASEALPE 334 >2RIO-A nrPDB Length = 434 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 70/325 (21%), Positives = 124/325 (38%), Gaps = 69/325 (21%) Query: 10 AEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHP 69 +G G+ GTV + G VA+K + + + E+ LL + +HP Sbjct: 21 KILGYGSSGTVVF-QGSFQGRPVAVKRMLID--------FCDIALMEIKLLTE--SDDHP 69 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL-----MRQF 124 NV+R T R + + E + +L+ ++ + K+ +RQ Sbjct: 70 NVIRYYCSETTDRF-----LYIALELCNLNLQDLVESKNVSDENLKLQKEYNPISLLRQI 124 Query: 125 LRGLDFLHANCIVHRDLKPENILVT-------------SGGTVKLADFGLARIYSYQMA- 170 G+ LH+ I+HRDLKP+NILV+ + ++DFGL + + Sbjct: 125 ASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSS 184 Query: 171 ----LTPVVVTLWYRAPEVLLQ-------STYATPVDMWSVGCIFAEMFR-RKPLFCGNS 218 L T +RAPE+L + +D++S+GC+F + K F Sbjct: 185 FRTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPF---- 240 Query: 219 EADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTF 278 D + R+ ++ RG F + + + L+ +M+ Sbjct: 241 ----------------GDKYSRESNIIRGIFSLDEMKCLHDRS--LIAEATDLISQMIDH 282 Query: 279 NPHKRISAFRALQHSYLHKDEGNPE 303 +P KR +A + L+H E Sbjct: 283 DPLKRPTAMKVLRHPLFWPKSKKLE 307 >4PL5-B nrPDB Length = 435 Score = 166 bits (420), Expect = 1e-41, Method: Composition-based stats. Identities = 83/310 (26%), Positives = 122/310 (39%), Gaps = 58/310 (18%) Query: 6 YEPVAEIGVGAYGT-VYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 + P +G GA GT VYK VA+K + REV LLR Sbjct: 29 FCPKDVLGHGAEGTIVYKG--MFDNRDVAVKRILPECFSFAD--------REVQLLRE-- 76 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 + EHPNV+R C + + E L+ Y+++ L E I L+ Q Sbjct: 77 SDEHPNVIRYF--CTEKDRQFQ---YIAIELCAATLQEYVEQKDFAHLGLEPI-TLLHQT 130 Query: 125 LRGLDFLHANCIVHRDLKPENILV---TSGGTVK--LADFGLARIYSYQMA----LTPVV 175 GL LH+ IVHRDLKP NIL+ + G +K ++DFGL + + + V Sbjct: 131 TSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVP 190 Query: 176 VTLWYRAPEVLLQSTY---ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGL 232 T + APE+L + VD++S GC+F + Sbjct: 191 GTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVIS----------------------- 227 Query: 233 PPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEES--GAQLLLEMLTFNPHKRISAFRAL 290 E P SL R A G + + E +L+ +M+ +P +R SA L Sbjct: 228 --EGYHPFGKSLQRQANILLGACNLDCFHSDKHEDVIARELIEKMIAMDPQQRPSAKHVL 285 Query: 291 QHSYLHKDEG 300 +H + E Sbjct: 286 KHPFFWSLEK 295 >5WNL-A nrPDB Length = 342 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 57/288 (19%), Positives = 115/288 (39%), Gaps = 42/288 (14%) Query: 10 AEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHP 69 ++G G +G VYK R H ++A+K + + E +++E + Sbjct: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKC---SPSLHVDDRERMELLEEA---KKMEMAKFR 79 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLD 129 ++ + +C V LV E+++ L + P LP + ++ + G++ Sbjct: 80 YILPVYGICQE-------PVGLVMEYMETGSLEKLLASEP--LPWDLRFRIVHETAVGMN 130 Query: 130 FLHANC--IVHRDLKPENILVTSGGTVKLADFGLARI----YSYQMALTPVVVTLWYRAP 183 FLH ++H +LKP NIL+ + VK++DFGLA+ +S+ +++ + T+ Y P Sbjct: 131 FLHCMSPPLLHLNLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPP 190 Query: 184 EVLLQST--YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 E + + + + T D++S + + +K F E + L + ++ Sbjct: 191 ERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFA--DEKNILHIMMKVV----------- 237 Query: 242 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 P+ P S L+ +P R + Sbjct: 238 ------KGHRPELPPICRPRPRACASLIGLMQRCWHADPQVRPTFQEI 279 >3AOX-A nrPDB Length = 344 Score = 165 bits (417), Expect = 3e-41, Method: Composition-based stats. Identities = 55/254 (21%), Positives = 101/254 (39%), Gaps = 30/254 (11%) Query: 4 SRYEPVAEIGVGAYGTVYKAR-----DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVA 58 + +G GA+G VY+ + + S VA+K++ + + E Sbjct: 47 KNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTL----PEVCSEQDELDFLMEAL 102 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPP-----GL 112 ++ + F H N+VR + V S ++ E + DL+++L + P L Sbjct: 103 IISK---FNHQNIVRCIGVSLQSLPR-----FILLELMAGGDLKSFLRETRPRPSQPSSL 154 Query: 113 PAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT---SGGTVKLADFGLARIY---S 166 + + R G +L N +HRD+ N L+T G K+ DFG+AR S Sbjct: 155 AMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRAS 214 Query: 167 YQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGK 225 Y ++ + + PE ++ + + D WS G + E+F + S + L Sbjct: 215 YYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEF 274 Query: 226 IFDLIGLPPEDDWP 239 + + P + P Sbjct: 275 VTSGGRMDPPKNCP 288 >4NEU-A nrPDB Length = 333 Score = 164 bits (416), Expect = 3e-41, Method: Composition-based stats. Identities = 64/302 (21%), Positives = 103/302 (34%), Gaps = 53/302 (17%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 M +S + AE+ G +G V G ++ G + + E ++ Sbjct: 21 MKSSDFLESAELDSGGFGKVSLCFHRTQGLM----IMKTVYKGPNCIEHNEALLEEAKMM 76 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKD 119 RL H VV+L+ V E K +LV E+++ +L L L + Sbjct: 77 NRLR---HSRVVKLLGVII-----EEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVK--GR 126 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY-------------- 165 ++ + + G+ +LH ++H+DLKPENILV + +K+AD GLA Sbjct: 127 IILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELR 186 Query: 166 SYQMALTPVVVTLWYRAPEVLLQSTY--ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQL 223 TL+Y APE L D++S + +F K + QL Sbjct: 187 EVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQL 246 Query: 224 GKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKR 283 P DD + L+ NP R Sbjct: 247 IMCIKSGNRPDVDD----------------------ITEYCPREIISLMKLCWEANPEAR 284 Query: 284 IS 285 + Sbjct: 285 PT 286 >1PY5-A nrPDB Length = 326 Score = 163 bits (414), Expect = 6e-41, Method: Composition-based stats. Identities = 76/304 (25%), Positives = 117/304 (38%), Gaps = 40/304 (13%) Query: 8 PVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 IG G +G V++ + G VA+K S RE + + + Sbjct: 33 LQESIGKGRFGEVWRGKWR--GEEVAVKIF--------SSREERSWFREAEIYQTV-MLR 81 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLR 126 H N++ + ++ LV ++ + L YL++ + E + L Sbjct: 82 HENILGFIAA-DNKDNGTWTQLWLVSDYHEHGSLFDYLNR---YTVTVEGMIKLALSTAS 137 Query: 127 GLDFLHAN--------CIVHRDLKPENILVTSGGTVKLADFGLARIYSY-----QMALTP 173 GL LH I HRDLK +NILV GT +AD GLA + +A Sbjct: 138 GLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNH 197 Query: 174 VVVTLWYRAPEVLLQSTYA------TPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIF 227 V T Y APEVL S D++++G +F E+ RR + G D + Sbjct: 198 RVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSI--GGIHEDYQLPYY 255 Query: 228 DLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAF 287 DL+ P + R V + P P QS E A+++ E N R++A Sbjct: 256 DLVPSDPSVEEMRKV-VCEQKLRPNIPNRWQSC--EALRVMAKIMRECWYANGAARLTAL 312 Query: 288 RALQ 291 R + Sbjct: 313 RIKK 316 >5TE0-A nrPDB Length = 347 Score = 163 bits (414), Expect = 6e-41, Method: Composition-based stats. Identities = 63/298 (21%), Positives = 107/298 (35%), Gaps = 54/298 (18%) Query: 8 PVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 + G + V+ R +G ALK + V N RE+ ++R L Sbjct: 23 VDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQV-----CKREIQIMRDLSG-- 74 Query: 68 HPNVVRLMDVCATSRTDREIK-VTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLMRQFL 125 H N+V +D + + ++ V ++ + + +++ G + + Sbjct: 75 HKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTC 134 Query: 126 RGLDFLHANC--IVHRDLKPENILVTSGGTVKLADFGLA--RIYSYQMALTPVV------ 175 + LH I+HRDLK ENIL+ G L DFG A + + Q V Sbjct: 135 EAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKK 194 Query: 176 -VTLWYRAPEVLL---QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIG 231 TL YRAPE++ T D+W++GC+ ++ F G S+ I D Sbjct: 195 YTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPF-GESQV----AICDGNF 249 Query: 232 LPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 P++ + L+ ML +P KR ++ Sbjct: 250 TIPDN-------------------------SRYSQDMHCLIRYMLEPDPDKRPDIYQV 282 >5C26-A nrPDB Length = 299 Score = 163 bits (413), Expect = 8e-41, Method: Composition-based stats. Identities = 56/281 (19%), Positives = 105/281 (37%), Gaps = 44/281 (15%) Query: 10 AEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHP 69 E+G G +GTV K +V++ L + E ++++L+ P Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVK-TVAVKILKNEANDPALKDELLAEANVMQQLDN---P 88 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 +VR++ +C LV E + L YL + + + I +L+ Q G+ Sbjct: 89 YIVRMIGICEAES------WMLVMEMAELGPLNKYLQQNRH--VKDKNIIELVHQVSMGM 140 Query: 129 DFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY----SYQMALTPVVVTLWYRAPE 184 +L + VHRDL N+L+ + K++DFGL++ +Y A T + + APE Sbjct: 141 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 200 Query: 185 VLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 + +++ D+WS G + E F + + G ++ + + PR Sbjct: 201 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPR--- 257 Query: 244 LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI 284 L+ T++ R Sbjct: 258 -----------------------EMYDLMNLCWTYDVENRP 275 >4G3E-A nrPDB Length = 352 Score = 162 bits (411), Expect = 1e-40, Method: Composition-based stats. Identities = 66/312 (21%), Positives = 104/312 (33%), Gaps = 64/312 (20%) Query: 11 EIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPN 70 +G G++G V++ +D +G A+K VR+ V L P Sbjct: 81 RVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFR-------------VEELVACAGLSSPR 127 Query: 71 VVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDF 130 +V L V + E ++ L K LP + + Q L GL++ Sbjct: 128 IVPLYGAVREG-----PWVNIFMELLEGGSLGQLIKQMGC-LPEDRALYYLGQALEGLEY 181 Query: 131 LHANCIVHRDLKPENILVTSGG-TVKLADFGLARIYSYQMALTPVV------VTLWYRAP 183 LH I+H D+K +N+L++S G L DFG A ++ T + AP Sbjct: 182 LHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAP 241 Query: 184 EVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVS 243 EV++ VD+WS C+ M W + Sbjct: 242 EVVMGKPCDAKVDIWSSCCMMLHMLNGCHP------------------------WTQYFR 277 Query: 244 LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA-------------L 290 P P P++ + P AQ + E L P R SA L Sbjct: 278 GPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKEPVHRASAMELRRKVGKALQEVGGL 337 Query: 291 QHSYLHKDEGNP 302 + + + P Sbjct: 338 KSPW-KGEYKEP 348 >4JLC-A nrPDB Length = 657 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 61/234 (26%), Positives = 94/234 (40%), Gaps = 28/234 (11%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G GA V++ R +G A+K + +RE +L++L H N+ Sbjct: 16 LGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ----MREFEVLKKL---NHKNI 68 Query: 72 VRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDK-APPPGLPAETIKDLMRQFLRGLD 129 V+L + + T + L+ E L T L++ + GLP ++R + G++ Sbjct: 69 VKLFAIEEETTTRHK---VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 125 Query: 130 FLHANCIVHRDLKPENIL--VTSGGT--VKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 L N IVHRD+KP NI+ + G KL DFG AR + T Y P++ Sbjct: 126 HLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 185 Query: 186 LL--------QSTYATPVDMWSVGCIFAEMFRRKPLFC----GNSEADQLGKIF 227 Q Y VD+WSVG F F + + KI Sbjct: 186 YERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 239 >4EUU-A nrPDB Length = 319 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 59/234 (25%), Positives = 94/234 (40%), Gaps = 28/234 (11%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G GA V++ R +G A+K + +RE +L++L H N+ Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ----MREFEVLKKL---NHKNI 69 Query: 72 VRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDK-APPPGLPAETIKDLMRQFLRGLD 129 V+L + + T + L+ E L T L++ + GLP ++R + G++ Sbjct: 70 VKLFAIEEETTTRHK---VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 126 Query: 130 FLHANCIVHRDLKPENIL--VTSGGT--VKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 L N IVHR++KP NI+ + G KL DFG AR + T Y P++ Sbjct: 127 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 186 Query: 186 LL--------QSTYATPVDMWSVGCIFAEMFRRKPLFC----GNSEADQLGKIF 227 Q Y VD+WS+G F F + + KI Sbjct: 187 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 240 >3UIM-A nrPDB Length = 326 Score = 161 bits (409), Expect = 2e-40, Method: Composition-based stats. Identities = 57/219 (26%), Positives = 91/219 (41%), Gaps = 15/219 (6%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 +A+ + +G G +G VYK R G VA+K ++ G + EV ++ Sbjct: 27 VASDNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLK----EERTQGGELQFQTEVEMI 81 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 H N++RL C T + + V LR + PP L + + Sbjct: 82 S---MAVHRNLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPP--LDWPKRQRI 136 Query: 121 MRQFLRGLDFLHAN---CIVHRDLKPENILVTSGGTVKLADFGLARIYSY--QMALTPVV 175 RGL +LH + I+HRD+K NIL+ + DFGLA++ Y T V Sbjct: 137 ALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVR 196 Query: 176 VTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLF 214 T+ + APE L + D++ G + E+ + F Sbjct: 197 GTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRAF 235 >4F0G-A nrPDB Length = 287 Score = 161 bits (409), Expect = 2e-40, Method: Composition-based stats. Identities = 67/284 (23%), Positives = 114/284 (40%), Gaps = 31/284 (10%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPI--STVREVA 58 +A + E +IG G +G V+K R VA+KS+ + + G + REV Sbjct: 16 LADNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVF 75 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETI 117 ++ L HPN+V+L + +V E V DL L P + Sbjct: 76 IMSNL---NHPNIVKLYGLMHNPPR-------MVMEFVPCGDLYHRLLDKAHP-IKWSVK 124 Query: 118 KDLMRQFLRGLDFLHANC--IVHRDLKPENIL---VTSGGTV--KLADFGLARIYSYQMA 170 LM G++++ IVHRDL+ NI + V K+ADFGL++ + + Sbjct: 125 LRLMLDIALGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSV- 183 Query: 171 LTPVVVTLWYRAPEVL--LQSTYATPVDMWSVGCIFAEMFRRKPLF----CGNSEADQLG 224 + ++ + APE + + +Y D +S I + + F G + + Sbjct: 184 -SGLLGNFQWMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMI 242 Query: 225 KIFDLIGLPPEDDWPRDVSLPRGAF--PPRGPRPVQSVVPEMEE 266 + L PED PR ++ + P+ +V E+ E Sbjct: 243 REEGLRPTIPEDCPPRLRNVIELCWSGDPKKRPHFSYIVKELSE 286 >4EUT-A nrPDB Length = 396 Score = 160 bits (406), Expect = 5e-40, Method: Composition-based stats. Identities = 59/234 (25%), Positives = 94/234 (40%), Gaps = 28/234 (11%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G GA V++ R +G A+K + +RE +L++L H N+ Sbjct: 17 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ----MREFEVLKKL---NHKNI 69 Query: 72 VRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDK-APPPGLPAETIKDLMRQFLRGLD 129 V+L + + T + L+ E L T L++ + GLP ++R + G++ Sbjct: 70 VKLFAIEEETTTRHK---VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 126 Query: 130 FLHANCIVHRDLKPENIL--VTSGGT--VKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 L N IVHR++KP NI+ + G KL DFG AR + T Y P++ Sbjct: 127 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 186 Query: 186 LL--------QSTYATPVDMWSVGCIFAEMFRRKPLFC----GNSEADQLGKIF 227 Q Y VD+WS+G F F + + KI Sbjct: 187 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 240 >5WNO-A nrPDB Length = 330 Score = 160 bits (406), Expect = 5e-40, Method: Composition-based stats. Identities = 58/287 (20%), Positives = 101/287 (35%), Gaps = 49/287 (17%) Query: 7 EPVAEIGVGAYGTVYKA-----RDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 + ++G GA+GTV+ R + VA+K + + E + Sbjct: 25 KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTD------EMLEEATNMF 78 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLM 121 RL H N+++++ C + + + +L+ +L K L A Sbjct: 79 RLR---HDNLLKIIGFCMHDDGLKIVTIYRPL----GNLQNFL-KLHKENLGAREQVLYC 130 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ---MALTPVVVTL 178 Q G+ +L +VHRDL N+LV V++ DFGL++I + + + V + Sbjct: 131 YQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADSITIKSGKVAI 190 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDD 237 + A E+ + Y D+W+ G E+ + + G S Sbjct: 191 KWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSI--------------- 235 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI 284 F G R S P + Q LL +P R Sbjct: 236 ---------HNFLKDGNR--LSQPPNCSQDLYQELLRCWMADPKSRP 271 >3G2F-A nrPDB Length = 336 Score = 158 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 75/312 (24%), Positives = 117/312 (37%), Gaps = 45/312 (14%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 + + IG G YG VYK VA+K N + + E + R + Sbjct: 13 DNLKLLELIGRGRYGAVYKG--SLDERPVAVKVFSFANRQ--------NFINEKNIYR-V 61 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMR 122 EH N+ R + D ++ LV E+ + L YL + L Sbjct: 62 PLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS---DWVSSCRLAH 118 Query: 123 QFLRGLDFLHAN---------CIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTP 173 RGL +LH I HRDL N+LV + GT ++DFGL+ + + P Sbjct: 119 SVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVRP 178 Query: 174 ---------VVVTLWYRAPEVLLQ-------STYATPVDMWSVGCIFAEMFRRKP-LFCG 216 V T+ Y APEVL + VDM+++G I+ E+F R LF G Sbjct: 179 GEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRCTDLFPG 238 Query: 217 NSEAD-QLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEM 275 S + Q+ ++ P +D VS + S+ S + + + Sbjct: 239 ESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSL---AVRSLKETIEDC 295 Query: 276 LTFNPHKRISAF 287 + R++A Sbjct: 296 WDQDAEARLTAQ 307 >6O8B-A nrPDB Length = 665 Score = 158 bits (399), Expect = 3e-39, Method: Composition-based stats. Identities = 59/234 (25%), Positives = 94/234 (40%), Gaps = 28/234 (11%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G GA V++ R +G A+K + +RE +L++L H N+ Sbjct: 23 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ----MREFEVLKKL---NHKNI 75 Query: 72 VRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDK-APPPGLPAETIKDLMRQFLRGLD 129 V+L + + T + L+ E L T L++ + GLP ++R + G++ Sbjct: 76 VKLFAIEEETTTRHK---VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 132 Query: 130 FLHANCIVHRDLKPENIL--VTSGGT--VKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 L N IVHR++KP NI+ + G KL DFG AR + T Y P++ Sbjct: 133 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHPDM 192 Query: 186 LL--------QSTYATPVDMWSVGCIFAEMFRRKPLFC----GNSEADQLGKIF 227 Q Y VD+WS+G F F + + KI Sbjct: 193 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 246 >6NT9-A nrPDB Length = 742 Score = 158 bits (399), Expect = 3e-39, Method: Composition-based stats. Identities = 59/234 (25%), Positives = 94/234 (40%), Gaps = 28/234 (11%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 +G GA V++ R +G A+K + +RE +L++L H N+ Sbjct: 15 LGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ----MREFEVLKKL---NHKNI 67 Query: 72 VRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDK-APPPGLPAETIKDLMRQFLRGLD 129 V+L + + T + L+ E L T L++ + GLP ++R + G++ Sbjct: 68 VKLFAIEEETTTRHK---VLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGGMN 124 Query: 130 FLHANCIVHRDLKPENIL--VTSGGT--VKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 L N IVHR++KP NI+ + G KL DFG AR + T Y P++ Sbjct: 125 HLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDM 184 Query: 186 LL--------QSTYATPVDMWSVGCIFAEMFRRKPLFC----GNSEADQLGKIF 227 Q Y VD+WS+G F F + + KI Sbjct: 185 YERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKII 238 >3LMG-A nrPDB Length = 344 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 52/283 (18%), Positives = 109/283 (38%), Gaps = 29/283 (10%) Query: 7 EPVAEIGVGAYGTVYKARDPHSGH----FVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 + +G G +GTV+K G V +K + +G + + Sbjct: 34 RKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDH-------MLA 86 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLM 121 + + +H ++VRL+ +C S + LV +++ L ++ + L + + + Sbjct: 87 IGSLDHAHIVRLLGLCPGSS------LQLVTQYLPLGSLLDHVRQHRG-ALGPQLLLNWG 139 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA---LTPVVVTL 178 Q +G+ +L + +VHR+L N+L+ S V++ADFG+A + + + Sbjct: 140 VQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPI 199 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLGKIFDLIGLPPEDD 237 + A E + Y D+WS G E+ + G A+ + L Sbjct: 200 KWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQ--- 256 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNP 280 P+ ++ + +++ P +E + M +P Sbjct: 257 -PQICTIDVYMVMVKCWMIDENIRPTFKELANEF-TRM-ARDP 296 >5XD6-A nrPDB Length = 305 Score = 155 bits (391), Expect = 3e-38, Method: Composition-based stats. Identities = 66/288 (22%), Positives = 108/288 (37%), Gaps = 30/288 (10%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 T Y + IG G+YG V+ SG A+K + + +V+++ R Sbjct: 21 TDNYGSKSLIGEGSYGRVFYGILK-SGKAAAIKKLDSSKQPD------QEFLAQVSMVSR 73 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLD-------KAPPPGLPA 114 L NVV L+ C L +E+ + L L P P L Sbjct: 74 LRQ---ENVVALLGYCVDGPLR-----VLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSW 125 Query: 115 ETIKDLMRQFLRGLDFLHAN---CIVHRDLKPENILVTSGGTVKLADFGLARI---YSYQ 168 + RGL++LH ++HRD+K N+L+ K+ADF L+ + + Sbjct: 126 HQRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLLFDDDVAKIADFDLSNQAPDMAAR 185 Query: 169 MALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD 228 + T V+ T Y APE + T +T D++S G + E+ + Q + Sbjct: 186 LHSTRVLGTFGYHAPEYAMTGTLSTKSDVYSFGVVLLELLTGRKPVDHTLPRGQQSVVTW 245 Query: 229 LIGLPPEDDWPRDVSL-PRGAFPPRGPRPVQSVVPEMEESGAQLLLEM 275 ED + V G +PP+ + +V + A M Sbjct: 246 ATPKLSEDKVKQCVDARLNGEYPPKAVAKLAAVAALCVQYEADFRPNM 293 >2H34-A nrPDB Length = 309 Score = 151 bits (382), Expect = 3e-37, Method: Composition-based stats. Identities = 63/232 (27%), Positives = 95/232 (40%), Gaps = 15/232 (6%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y +G G G VY+A D VALK + RE RL+ Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMS--ETLSSDPVFRTRMQREARTAGRLQE 93 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQF 124 P+VV + D + + ++ + ++ DL L + P L ++RQ Sbjct: 94 ---PHVVPIHDF-----GEIDGQLYVDMRLINGVDLAAMLRRQGP--LAPPRAVAIVRQI 143 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM--ALTPVVVTLWYRA 182 LD HA HRD+KPENILV++ L DFG+A + + L V TL+Y A Sbjct: 144 GSALDAAHAAGATHRDVKPENILVSADDFAYLVDFGIASATTDEKLTQLGNTVGTLYYMA 203 Query: 183 PEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 PE +S D++++ C+ E P + G+ + I I P Sbjct: 204 PERFSESHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPS 255 >6BFN-A nrPDB Length = 342 Score = 146 bits (370), Expect = 8e-36, Method: Composition-based stats. Identities = 58/225 (25%), Positives = 89/225 (39%), Gaps = 26/225 (11%) Query: 2 ATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLR 61 T + +IG G +G VY+A ++ A+K ++ N + S + EV Sbjct: 20 GTHNFSEELKIGEGGFGCVYRAVMRNT--VYAVKRLK-ENADLEWTAVKQSFLTEVE--- 73 Query: 62 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRT---YLDKAPPPGLPAETIK 118 +L F HPN+V CA + LV+ + + P L Sbjct: 74 QLSRFRHPNIVDFAGYCAQNGF-----YCLVYGFLPNGSLEDRLHCQTQACPPLSWPQRL 128 Query: 119 DLMRQFLRGLDFLH--ANCIVHRDLKPENILVTSGGTVKLADFGLARI---------YSY 167 D++ R + FLH + ++H D+K N+L+ T KL DFGLAR S Sbjct: 129 DILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPSQSS 188 Query: 168 QMALTPVV-VTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRK 211 +A T V TL Y E + A D +S G + E + Sbjct: 189 MVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQ 233 >3SOC-A nrPDB Length = 322 Score = 146 bits (370), Expect = 8e-36, Method: Composition-based stats. Identities = 59/299 (19%), Positives = 112/299 (37%), Gaps = 38/299 (12%) Query: 7 EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF 66 + + G +G V+KA+ +VA+K + + + + L Sbjct: 27 QLLEVKARGRFGCVWKAQ--LLNEYVAVKIFPIQDKQSWQNEYEVYS---------LPGM 75 Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFL 125 +H N+++ + T ++ + L+ + L +L + + + Sbjct: 76 KHENILQFIGA-EKRGTSVDVDLWLITAFHEKGSLSDFLKANV---VSWNELCHIAETMA 131 Query: 126 RGLDFLHAN----------CIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA---LT 172 RGL +LH + I HRD+K +N+L+ + T +ADFGLA + + Sbjct: 132 RGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTH 191 Query: 173 PVVVTLWYRAPEVL-----LQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIF 227 V T Y APEVL Q +DM+++G + E+ R G + L Sbjct: 192 GQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEE 251 Query: 228 DLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISA 286 ++ P +D V + R + + + E+ + E + R+SA Sbjct: 252 EIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCET----IEECWDHDAEARLSA 306 >4M66-A nrPDB Length = 325 Score = 146 bits (370), Expect = 9e-36, Method: Composition-based stats. Identities = 64/300 (21%), Positives = 104/300 (34%), Gaps = 43/300 (14%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 ++ + + +G G +G V++A H VA+K V EV + Sbjct: 17 VSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISW-----------EVKAM 65 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 L NV+ L+ V + D LV ++ L + P P + L Sbjct: 66 VNLRN---ENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPEAPR-PWPLLCRL 121 Query: 121 MRQFLRGLDFLHANC--IVHRDLKPENILVTSGGTVKLADFGLARIY-------SYQMAL 171 +++ + G+ +LH+ ++HRDLKP NIL+ KLADFGL+ Sbjct: 122 LQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGS 181 Query: 172 TPVVVTLWYRAPEVLL--QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDL 229 TL Y PE+L + D++S G + + + ++ D Sbjct: 182 RDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGR-----------EAELVDK 230 Query: 230 IGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 L E R P PP P E +L++ R S Sbjct: 231 TSLIRETVCDRQSRPPLTELPPGSPE------TPGLEKLKELMIHCWGSQSENRPSFQDC 284 >5E8V-A nrPDB Length = 316 Score = 143 bits (362), Expect = 6e-35, Method: Composition-based stats. Identities = 68/309 (22%), Positives = 110/309 (35%), Gaps = 49/309 (15%) Query: 7 EPVAEIGVGAYGTVYKARDPHSG----HFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 E +G G + VYKA+ + VA+K P ++ L Sbjct: 12 ELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIF--PYEEYASWKTEKDIFSDINL--- 66 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 +H N+++ + + + H +L+ YL + + E ++ L Sbjct: 67 ----KHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHV---ISWEDLRKLGS 119 Query: 123 QFLRGLDFLHANC---------IVHRDLKPENILVTSGGTVKLADFGLARIYSY-----Q 168 RG+ LH++ IVHRDLK NILV + T L DFGL+ Sbjct: 120 SLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDD 179 Query: 169 MALTPVVVTLWYRAPEVLLQST------YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQ 222 +A + V T Y APEVL + D++S+ + EM R A Sbjct: 180 LANSGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALVLWEMTSRC-------NAVG 232 Query: 223 LGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQL----LLEMLTF 278 K ++ + P S+ G + S + G Q+ L E Sbjct: 233 EVKDYEPPFGSKVREHPCVASMADNVLADAGRPEIPSFW--LNHQGIQMVCETLTECWDH 290 Query: 279 NPHKRISAF 287 +P R++A Sbjct: 291 DPEARLTAQ 299 >4F9B-A nrPDB Length = 361 Score = 143 bits (362), Expect = 7e-35, Method: Composition-based stats. Identities = 74/354 (20%), Positives = 120/354 (33%), Gaps = 80/354 (22%) Query: 6 YEPVAEIGVGAYGTVYKARD---PHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 ++ +IG G + +VY A +ALK + PI E+ L Sbjct: 23 FKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHL-------IPTSHPIRIAAELQCLTV 75 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 + NV+ + + V + +++ + + L + +++ M Sbjct: 76 AGGQD--NVMGVKYCF-----RKNDHVVIAMPYLEHESFLDILN----SLSFQEVREYML 124 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSG-GTVKLADFGLAR------------------ 163 + L +H IVHRD+KP N L L DFGLA+ Sbjct: 125 NLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQ 184 Query: 164 -----------IYSYQMALTPVVVTLWYRAPEVLLQSTY-ATPVDMWSVGCIFAEMFRRK 211 S + + P T +RAPEVL + T +DMWS G IF + + Sbjct: 185 QERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGR 244 Query: 212 PLFC-GNSEADQLGKIFDLIGL-------------------PPEDDWPR--------DVS 243 F + + L +I + G P D + D S Sbjct: 245 YPFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSS 304 Query: 244 LPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 P+ +G E+ + LL ++L NP RI+A AL H + Sbjct: 305 TPKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKD 358 >2PZI-A nrPDB Length = 681 Score = 141 bits (356), Expect = 4e-34, Method: Composition-based stats. Identities = 62/292 (21%), Positives = 109/292 (37%), Gaps = 51/292 (17%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPH-SGHFVALKSVRVPNGGGGGGGLPISTVREVAL 59 + +YE I G G +Y A D + +G V LK + + G R+ Sbjct: 77 IVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGL--VHSGDAEAQAMAMAERQF-- 132 Query: 60 LRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKD 119 L HP++V++ + + + +V E+V L ++ LP Sbjct: 133 ---LAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGG---QSLKRSKGQKLPVAEAIA 186 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFG-LARIYSYQMALTPVVVTL 178 + + L L +LH+ +V+ DLKPENI++T +KL D G ++RI S+ T Sbjct: 187 YLLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTP 241 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 ++APE++ D+++VG A + P G + GLP +D Sbjct: 242 GFQAPEIVRTGP-TVATDIYTVGRTLAALTLDLPTRNGRY----------VDGLPEDDPV 290 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRAL 290 + LL + +P +R + + Sbjct: 291 LKTYDSYGR-----------------------LLRRAIDPDPRQRFTTAEEM 319 >4Y12-A nrPDB Length = 375 Score = 141 bits (355), Expect = 4e-34, Method: Composition-based stats. Identities = 62/292 (21%), Positives = 109/292 (37%), Gaps = 51/292 (17%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPH-SGHFVALKSVRVPNGGGGGGGLPISTVREVAL 59 + +YE I G G +Y A D + +G V LK + + G R+ Sbjct: 116 IVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGL--VHSGDAEAQAMAMAERQF-- 171 Query: 60 LRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKD 119 L HP++V++ + + + +V E+V L ++ LP Sbjct: 172 ---LAEVVHPSIVQIFNFVEHTDRHGDPVGYIVMEYVGG---QSLKRSKGQKLPVAEAIA 225 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFG-LARIYSYQMALTPVVVTL 178 + + L L +LH+ +V+ DLKPENI++T +KL D G ++RI S+ T Sbjct: 226 YLLEILPALSYLHSIGLVYNDLKPENIMLTEE-QLKLIDLGAVSRINSFGYLY----GTP 280 Query: 179 WYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDW 238 ++APE++ D+++VG A + P G + GLP +D Sbjct: 281 GFQAPEIVRTGP-TVATDIYTVGRTLAALTLDLPTRNGRY----------VDGLPEDDPV 329 Query: 239 PRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRAL 290 + LL + +P +R + + Sbjct: 330 LKTYDSYGR-----------------------LLRRAIDPDPRQRFTTAEEM 358 >4MWI-A nrPDB Length = 294 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 57/270 (21%), Positives = 103/270 (38%), Gaps = 42/270 (15%) Query: 32 VALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTL 91 VA+K + G + + +E+ + ++ FE PN++R+ +C T + ++ Sbjct: 50 VAIKVFKKLQAGSI-AIVRQTFNKEI---KTMKKFESPNILRIFGICID-ETVTPPQFSI 104 Query: 92 VFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCI--VHRDLKPENILV 148 V E+ + LR LD+ L + L+ RGL LH + +H ++ N LV Sbjct: 105 VMEYCELGTLRELLDREKDLTLGKRMV--LVLGAARGLYRLHHSEAPELHGKIRSSNFLV 162 Query: 149 TSGGTVKLADFGL-----ARIYSYQMALTPVVVTLWYRAPEVLLQ--STYATPVDMWSVG 201 T G VKLA F L + T V + Y +P+ L Y +++S G Sbjct: 163 TQGYQVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFG 222 Query: 202 CIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVV 261 + E+ F G ++++ K+ + R P+ Sbjct: 223 IVLWEIATGDIPFQG-CNSEKIRKLVAV---------------------KRQQEPLGEDC 260 Query: 262 PEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 P +++ E +P R S L+ Sbjct: 261 PS---ELREIIDECRAHDPSVRPSVDEILK 287 >2Y4I-B nrPDB Length = 319 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 61/305 (20%), Positives = 110/305 (36%), Gaps = 42/305 (13%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 + E IG G +G VY R VA+ R+ + + REV R+ Sbjct: 33 EQLEIGELIGKGRFGQVYHGRWHG---EVAI---RLIDIERDNEDQLKAFKREVMAYRQ- 85 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 H NVV M C + + ++ + + L + + ++ Sbjct: 86 --TRHENVVLFMGACMSP-----PHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQE 138 Query: 124 FLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYS------YQMALTPVVVT 177 ++G+ +LHA I+H+DLK +N+ G V + DFGL I + L Sbjct: 139 IVKGMGYLHAKGILHKDLKSKNVFYD-NGKVVITDFGLFSISGVLQAGRREDKLRIQNGW 197 Query: 178 LWYRAPEVLLQ---------STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD 228 L + APE++ Q ++ D++++G I+ E+ R+ F + ++ Sbjct: 198 LCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGT 257 Query: 229 LIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFR 288 + P + G + E + +L+ ML P + R Sbjct: 258 GMK-------PNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMD-MLEKLPKR----NR 305 Query: 289 ALQHS 293 L H Sbjct: 306 RLSHP 310 >5AR8-A nrPDB Length = 326 Score = 137 bits (345), Expect = 7e-33, Method: Composition-based stats. Identities = 61/295 (20%), Positives = 110/295 (37%), Gaps = 41/295 (13%) Query: 9 VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEH 68 + + GA GTV AR VA+K + + +RE +L + Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSE--RKDVLREAEILHKARFS-- 92 Query: 69 PNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLDKAPP-PGLPAETIKDLMRQFLR 126 ++ ++ +C + +V E++ + L L + P + ++ + Sbjct: 93 -YILPILGICNEPEF-----LGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIAL 146 Query: 127 GLDFLHANC--IVHRDLKPENILVTSGGTVKLADFGLAR------IYSYQMALTPVVVTL 178 G+++LH ++H DLK +NIL+ + VK+ADFGL++ S P T+ Sbjct: 147 GVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTI 206 Query: 179 WYRAPEVL---LQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPE 235 Y PE +S + D++S I E+ RK F + Q+ Sbjct: 207 IYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQI------------ 254 Query: 236 DDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRAL 290 S+ +G P + +P L+ NP +R S + L Sbjct: 255 -----MYSVSQGHRPVINEESLPYDIPH-RARMISLIESGWAQNPDERPSFLKCL 303 >3HNG-A nrPDB Length = 360 Score = 135 bits (341), Expect = 2e-32, Method: Composition-based stats. Identities = 48/203 (23%), Positives = 81/203 (39%), Gaps = 14/203 (6%) Query: 76 DVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANC 135 + A+S + ++ V E D D + E + Q RG++FL + Sbjct: 166 ESFASSGFQEDKSLSDVEEEEDSDGFY------KEPITMEDLISYSFQVARGMEFLSSRK 219 Query: 136 IVHRDLKPENILVTSGGTVKLADFGLARIY---SYQMALTPVVVTLWYRAPEVLLQSTYA 192 +HRDL NIL++ VK+ DFGLAR + + L + APE + Y+ Sbjct: 220 CIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYS 279 Query: 193 TPVDMWSVGCIFAEMFR-RKPLFCGNS-EADQLGKIFDLIGL-PPEDDWPRDVSLPRGAF 249 T D+WS G + E+F + G + D ++ + + + PE P + + Sbjct: 280 TKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCW 339 Query: 250 PPRGPRPVQSVVPEMEESGAQLL 272 + E+ E LL Sbjct: 340 HRDPKE--RPRFAELVEKLGDLL 360 Score = 64.2 bits (155), Expect = 7e-11, Method: Composition-based stats. Identities = 25/127 (19%), Positives = 46/127 (36%), Gaps = 16/127 (12%) Query: 1 MATSRYEPVAEIGVGAYGTVYKA-----RDPHSGHFVALKSVRVPNGGGGGGGLPISTVR 55 A R + +G GA+G V +A + + VA+K ++ G + + Sbjct: 24 FARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLK----EGATASEYKALMT 79 Query: 56 EVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPA 114 E+ +L + H NVV L+ C + ++ E+ +L YL Sbjct: 80 ELKILTHIG--HHLNVVNLLGACTKQG----GPLMVIVEYCKYGNLSNYLKSKRDLFFLN 133 Query: 115 ETIKDLM 121 + M Sbjct: 134 KDAALHM 140 >5VC6-A nrPDB Length = 289 Score = 134 bits (338), Expect = 4e-32, Method: Composition-based stats. Identities = 65/316 (20%), Positives = 116/316 (36%), Gaps = 69/316 (21%) Query: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 T+ + + +IG G +G+V+K G A+K + P G + +REV Sbjct: 10 TTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKP---LAGSVDEQNALREVYAHAV 66 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPP--PGLPAETIKD 119 L +H +VVR A + + + E+ + L + + +KD Sbjct: 67 LG--QHSHVVRYFSAWA-----EDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKD 119 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTV-------------------KLADFG 160 L+ Q RGL ++H+ +VH D+KP NI ++ K+ D G Sbjct: 120 LLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLG 179 Query: 161 -LARIYSYQMALTPVVVTLWYRAPEVLLQSTYAT--PVDMWSVGCIFAEMFRRKPLFCGN 217 + RI S Q+ + A EVL ++ Y D++++ +PL Sbjct: 180 HVTRISSPQVEEGDS----RFLANEVLQEN-YTHLPKADIFALALTVVCAAGAEPL---P 231 Query: 218 SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLT 277 DQ +I + + + + +LL M+ Sbjct: 232 RNGDQWHEIRQG--------------------------RLPRIPQVLSQEFTELLKVMIH 265 Query: 278 FNPHKRISAFRALQHS 293 +P +R SA ++HS Sbjct: 266 PDPERRPSAMALVKHS 281 >4M69-B nrPDB Length = 283 Score = 134 bits (338), Expect = 5e-32, Method: Composition-based stats. Identities = 60/282 (21%), Positives = 111/282 (39%), Gaps = 42/282 (14%) Query: 18 GTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDV 77 T+Y+ S V +K P G + + E+ + ++ F+ PN++R+ + Sbjct: 23 STIYRGEYHRS--PVTIKVFNNPQAESVG-IVRFTFNDEI---KTMKKFDSPNILRIFGI 76 Query: 78 CATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCI 136 C +T + + ++V E+ + LR LD+ + ++ L+ + RGL LH + Sbjct: 77 CID-QTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSL--LVLRAARGLYRLHHSET 133 Query: 137 VHRDLKPENILVTSGGTVKLADFGLARIYSY-----QMALTPVVVTLWYRAPEVLLQ--S 189 +HR++ + LV G VKLA F L++ + + + Y +PE L Sbjct: 134 LHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFC 193 Query: 190 TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAF 249 Y +++S G + E+ K F G KI +L+ Sbjct: 194 LYDIKAEIYSFGIVLWEIATGKIPFEGCDS----KKIRELVA------------------ 231 Query: 250 PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 + PV PE+ ++ E P +R S L+ Sbjct: 232 EDKKQEPVGQDCPELLRE---IINECRAHEPSQRPSVDGILE 270 >3VHK-A nrPDB Length = 368 Score = 133 bits (336), Expect = 6e-32, Method: Composition-based stats. Identities = 40/188 (21%), Positives = 67/188 (35%), Gaps = 29/188 (15%) Query: 109 PPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIY--- 165 L E + Q +G++FL + +HRDL NIL++ VK+ DFGLAR Sbjct: 194 KDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKD 253 Query: 166 SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEADQLG 224 + + L + APE + Y D+WS G + E+F + G ++ Sbjct: 254 PDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFC 313 Query: 225 KIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI 284 + D+ PEM ++ P +R Sbjct: 314 RRLKEGTRMRAPDY---------------------TTPEMYQTMLD----CWHGEPSQRP 348 Query: 285 SAFRALQH 292 + ++H Sbjct: 349 TFSELVEH 356 Score = 66.1 bits (160), Expect = 2e-11, Method: Composition-based stats. Identities = 29/126 (23%), Positives = 49/126 (38%), Gaps = 16/126 (12%) Query: 4 SRYEPVAEIGVGAYGTVYKA----RDP-HSGHFVALKSVRVPNGGGGGGGLPISTVREVA 58 R + +G GA+G V +A D + VA+K ++ G + + E+ Sbjct: 29 DRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLK----EGATHSEHRALMSELK 84 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETI 117 +L + H NVV L+ C + ++ E +L TYL +P +T Sbjct: 85 IL--IHIGHHLNVVNLLGACTKPG----GPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTK 138 Query: 118 KDLMRQ 123 RQ Sbjct: 139 GARFRQ 144 >4BTF-A nrPDB Length = 469 Score = 133 bits (336), Expect = 7e-32, Method: Composition-based stats. Identities = 60/282 (21%), Positives = 111/282 (39%), Gaps = 42/282 (14%) Query: 18 GTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDV 77 T+Y+ S V +K P G + + E+ + ++ F+ PN++R+ + Sbjct: 209 STIYRGEYHRS--PVTIKVFNNPQAESVG-IVRFTFNDEI---KTMKKFDSPNILRIFGI 262 Query: 78 CATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCI 136 C +T + + ++V E+ + LR LD+ + ++ L+ + RGL LH + Sbjct: 263 CID-QTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSL--LVLRAARGLYRLHHSET 319 Query: 137 VHRDLKPENILVTSGGTVKLADFGLARIYSY-----QMALTPVVVTLWYRAPEVLLQ--S 189 +HR++ + LV G VKLA F L++ + + + Y +PE L Sbjct: 320 LHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFC 379 Query: 190 TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAF 249 Y +++S G + E+ K F G KI +L+ Sbjct: 380 LYDIKAEIYSFGIVLWEIATGKIPFEGCDS----KKIRELVA------------------ 417 Query: 250 PPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 + PV PE+ ++ E P +R S L+ Sbjct: 418 EDKKQEPVGQDCPELLRE---IINECRAHEPSQRPSVDGILE 456 >2QLU-A nrPDB Length = 314 Score = 133 bits (336), Expect = 7e-32, Method: Composition-based stats. Identities = 67/296 (22%), Positives = 111/296 (37%), Gaps = 45/296 (15%) Query: 14 VGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVR 73 G +G V+KA+ + FVA+K + + + RE+ +H N+++ Sbjct: 25 RGRFGCVWKAQLMND--FVAVKIFPLQDKQS------WQSEREIF---STPGMKHENLLQ 73 Query: 74 LMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLH 132 + ++ E+++ L+ D L YL + + + RGL +LH Sbjct: 74 FIAA-EKRGSNLEVELWLITAFHDKGSLTDYL---KGNIITWNELCHVAETMSRGLSYLH 129 Query: 133 AN-----------CIVHRDLKPENILVTSGGTVKLADFGLARIYSYQM---ALTPVVVTL 178 + I HRD K +N+L+ S T LADFGLA + V T Sbjct: 130 EDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTHGQVGTR 189 Query: 179 WYRAPEVL-----LQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLP 233 Y APEVL Q +DM+++G + E+ R G + L ++ P Sbjct: 190 RYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHP 249 Query: 234 PEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQL---LLEMLTFNPHKRISA 286 ++ V + RP AQL + E + R+SA Sbjct: 250 SLEELQEVV-------VHKKMRPTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSA 298 >4BTK-A nrPDB Length = 337 Score = 133 bits (335), Expect = 8e-32, Method: Composition-based stats. Identities = 58/280 (20%), Positives = 107/280 (38%), Gaps = 34/280 (12%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVR-EVAL 59 + R++ + +IG G +G +Y+A D + VALK P ++ EVA+ Sbjct: 53 VVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV--------ESAQQPKQVLKMEVAV 104 Query: 60 LRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKD 119 L++L+ +H V R + + + +V + ++L P T Sbjct: 105 LKKLQGKDH--VCRFIGCGRNEKFN-----YVVMQLQGRNLADLRRSQPRGTFTLSTTLR 157 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENI----LVTSGGTVKLADFGLARIYSYQM------ 169 L +Q L ++ +H+ +HRD+KP N L ++ + DFGLAR Y+ Sbjct: 158 LGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPP 217 Query: 170 -ALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD 228 + T+ Y + D+WS+ + E + + + +Q+G I + Sbjct: 218 RNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKE 277 Query: 229 LIG-------LPPEDDWPRDVSLPRGAFPPRGPRPVQSVV 261 +P E D F + + SV Sbjct: 278 KYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVF 317 >4NFN-A nrPDB Length = 309 Score = 132 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 58/280 (20%), Positives = 107/280 (38%), Gaps = 34/280 (12%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVR-EVAL 59 + R++ + +IG G +G +Y+A D + VALK P ++ EVA+ Sbjct: 18 VVKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV--------ESAQQPKQVLKMEVAV 69 Query: 60 LRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKD 119 L++L+ +H V R + + + +V + ++L P T Sbjct: 70 LKKLQGKDH--VCRFIGCGRNEKFN-----YVVMQLQGRNLADLRRSQPRGTFTLSTTLR 122 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENI----LVTSGGTVKLADFGLARIYSYQM------ 169 L +Q L ++ +H+ +HRD+KP N L ++ + DFGLAR Y+ Sbjct: 123 LGKQILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPP 182 Query: 170 -ALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFD 228 + T+ Y + D+WS+ + E + + + +Q+G I + Sbjct: 183 RNVAGFRGTVRYASVNAHKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKE 242 Query: 229 LIG-------LPPEDDWPRDVSLPRGAFPPRGPRPVQSVV 261 +P E D F + + SV Sbjct: 243 KYEHRMLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVF 282 >5VDK-A nrPDB Length = 297 Score = 131 bits (330), Expect = 3e-31, Method: Composition-based stats. Identities = 68/316 (21%), Positives = 111/316 (35%), Gaps = 73/316 (23%) Query: 3 TSRYEP----VAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVA 58 SRYE V +IGVG +GTVYK G A+K S + EV Sbjct: 10 ASRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKRSMKTFTELSNEN---SALHEVY 66 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPG--LPAE 115 L HP+VVR S + + + E+ + L+ + + G Sbjct: 67 AHAVLG--HHPHVVRYY-----SSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNHFEEP 119 Query: 116 TIKDLMRQFLRGLDFLHANCIVHRDLKPENI-----------------------LVTSGG 152 +KD++ Q GL+++H + +VH D+KP NI +++ Sbjct: 120 KLKDILLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANV 179 Query: 153 TVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQS-TYATPVDMWSVGCIFAEMFRRK 211 K+ D G A + + A E+L + + D++++G A + Sbjct: 180 MYKIGDLGHATSINKPKVEEGDS---RFLANEILQEDYRHLPKADIFALGLTIAVAAGAE 236 Query: 212 PLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQL 271 L + + K G FP V E+ ES + L Sbjct: 237 SLPTNGAAWHHIRK---------------------GNFP--------DVPQELSESFSSL 267 Query: 272 LLEMLTFNPHKRISAF 287 L M+ + +R SA Sbjct: 268 LKNMIQPDAEQRPSAA 283 >5L2Q-C nrPDB Length = 320 Score = 130 bits (327), Expect = 8e-31, Method: Composition-based stats. Identities = 58/304 (19%), Positives = 103/304 (33%), Gaps = 62/304 (20%) Query: 21 YKARDPHSGHFVALKSVRVPNGGGGGGGLPISTV------REVALLRRLEAFEHPNVVRL 74 AR + F LK + + G G E +LL L + VV Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQD--GVVHH 90 Query: 75 MDVCATSRTD-------------REIKVTLVFEHVDQ-----------DLRTYLDKAPPP 110 + + + ++ LV + + +L+ Y+ K Sbjct: 91 HGLFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKR- 149 Query: 111 GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGT-VKLADFGLARIY-SYQ 168 L + +R ++ LH IVHRDLK N+++ + + +F L + S Sbjct: 150 -LSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEG 208 Query: 169 MALTPVVVTLWYRAPEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIF 227 L + Y +P+VL Y P DMW++G + M + F + + KI Sbjct: 209 DLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIK 268 Query: 228 DLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAF 287 PED + E+ L+ ++L +P +R++A Sbjct: 269 AAEYTIPEDG-------------------------RVSENTVCLIRKLLVLDPQQRLAAA 303 Query: 288 RALQ 291 L+ Sbjct: 304 DVLE 307 >5J0A-A nrPDB Length = 300 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 57/299 (19%), Positives = 105/299 (35%), Gaps = 32/299 (10%) Query: 10 AEIGVGAYGTVYKARDPHSGH---FVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF 66 ++G G VY + G A+K + + E +L+ L Sbjct: 15 QKLGFGTGVNVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSL--- 71 Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHV-DQDLRTYLD---KAPPPGLPAETIKDLMR 122 HPN+V + + L E+ ++ L ++ KA PA I + Sbjct: 72 HHPNIVGYRAF----TEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVAL 127 Query: 123 QFLRGLDFLH-ANCIVHRDLKPENILVTSGG-TVKLADFGLARIYSYQMALTP----VVV 176 RGL +LH ++H D+K N+++ T+K+ D G++ M +T + Sbjct: 128 NMARGLKYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIG 187 Query: 177 TLWYRAPEVLLQSTY-ATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPE 235 T ++ E + ++ D+++ G EM + D E Sbjct: 188 TEPWKPKEAVEENGVITDKADIFAFGLTLWEMMTLSIP-----HINLSNDDDDEDKTFDE 242 Query: 236 DDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAF---RALQ 291 D+ + A R P ++ + E + +L +P R SA AL+ Sbjct: 243 SDFDDEAYY--AALGTRPPINMEEL-DESYQKVIELFSVCTNEDPKDRPSAAHIVEALE 298 >4JRN-A nrPDB Length = 372 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 60/315 (19%), Positives = 104/315 (33%), Gaps = 62/315 (19%) Query: 12 IGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTV----REVALLRRLEAFE 67 +G G + TVY+A D + +A+K L + R +L + + + Sbjct: 76 LGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAKDAQ 135 Query: 68 HP-------NVVRLMD------VCATSRTDREIKVTLVFEHVDQDLRTYLD------KAP 108 +VV L V T L+ + D+ + Sbjct: 136 ESCRFMVPSDVVMLEGQPASTEVVIGLTTRWVPNYFLLMMRAEADMSKVISWVFGDASVN 195 Query: 109 PPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQ 168 L Q ++ + + A IVH D+KP N L+ G + L DFG RI + Sbjct: 196 KSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLLLKDGRLFLGDFGTYRINN-- 253 Query: 169 MALTPVVVTLWYRAPEVLLQS---TYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGK 225 ++ + T Y PE Q+ TY P D W +G ++ ++ + D L Sbjct: 254 -SVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTPADGIWDYLH- 311 Query: 226 IFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 D P L + L+ +L +P KR+ Sbjct: 312 ---------FADCPSTPELVQ-----------------------DLIRSLLNRDPQKRML 339 Query: 286 AFRALQHSYLHKDEG 300 +AL+ + + + Sbjct: 340 PLQALETAAFKEMDS 354 >4RT7-A nrPDB Length = 415 Score = 124 bits (311), Expect = 5e-29, Method: Composition-based stats. Identities = 42/185 (22%), Positives = 66/185 (35%), Gaps = 29/185 (15%) Query: 105 DKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI 164 ++ L E + Q +G++FL VHRDL N+LVT G VK+ DFGLAR Sbjct: 233 EEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARD 292 Query: 165 Y---SYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFR-RKPLFCGNSEA 220 S + + + + APE L + Y D+WS G + E+F + G Sbjct: 293 IMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVD 352 Query: 221 DQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNP 280 K+ + + + ++ F+ Sbjct: 353 ANFYKLIQNGFKMDQPFYATEEIYI-------------------------IMQSCWAFDS 387 Query: 281 HKRIS 285 KR S Sbjct: 388 RKRPS 392 Score = 75.3 bits (184), Expect = 3e-14, Method: Composition-based stats. Identities = 26/114 (22%), Positives = 44/114 (38%), Gaps = 17/114 (14%) Query: 4 SRYEPVAEIGVGAYGTVYKARD---PHSG--HFVALKSVRVPNGGGGGGGLPISTVREVA 58 E +G GA+G V A +G VA+K ++ + + E+ Sbjct: 65 ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLK----EKADSSEREALMSELK 120 Query: 59 LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPG 111 ++ +L + H N+V L+ C S + L+FE+ DL YL Sbjct: 121 MMTQLGS--HENIVNLLGACTLSGP-----IYLIFEYCCYGDLLNYLRSKREKF 167 >6DC0-A nrPDB Length = 292 Score = 123 bits (309), Expect = 8e-29, Method: Composition-based stats. Identities = 50/282 (17%), Positives = 91/282 (32%), Gaps = 52/282 (18%) Query: 20 VYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCA 79 V +A H+G + K + + ++ H N+ +++V Sbjct: 22 VSRALCIHTGRELRCKVFPIKHYQDKIRPY-------------IQLPSHSNITGIVEVIL 68 Query: 80 TSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHR 139 E K + FE D+ +Y+ L E L +Q + + H + IV Sbjct: 69 -----GETKAYVFFEKDFGDMHSYVRSRKR--LREEEAARLFKQIVSAVAHCHQSAIVLG 121 Query: 140 DLKPENILVT--SGGTVKLADFGLARIYS-YQMALTPVVVTLWYRAPEVLLQ-STYA-TP 194 DLK + + ++L I AL+ Y +PE+L TY+ Sbjct: 122 DLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKA 181 Query: 195 VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGP 254 D+WS+G + + + F + + KI PE Sbjct: 182 ADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEH------------------ 223 Query: 255 RPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 + L+ +L P +R++A L H + Sbjct: 224 ---------ISPKARCLIRSLLRREPSERLTAPEILLHPWFE 256 >5CEK-A nrPDB Length = 263 Score = 123 bits (309), Expect = 9e-29, Method: Composition-based stats. Identities = 50/282 (17%), Positives = 91/282 (32%), Gaps = 52/282 (18%) Query: 20 VYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCA 79 V +A H+G + K + + ++ H N+ +++V Sbjct: 25 VSRALCIHTGRELRCKVFPIKHYQDKIRPY-------------IQLPSHSNITGIVEVIL 71 Query: 80 TSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHR 139 E K + FE D+ +Y+ L E L +Q + + H + IV Sbjct: 72 -----GETKAYVFFEKDFGDMHSYVRSRKR--LREEEAARLFKQIVSAVAHCHQSAIVLG 124 Query: 140 DLKPENILVT--SGGTVKLADFGLARIYS-YQMALTPVVVTLWYRAPEVLLQ-STYA-TP 194 DLK + + ++L I AL+ Y +PE+L TY+ Sbjct: 125 DLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKA 184 Query: 195 VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGP 254 D+WS+G + + + F + + KI PE Sbjct: 185 ADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEH------------------ 226 Query: 255 RPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 + L+ +L P +R++A L H + Sbjct: 227 ---------ISPKARCLIRSLLRREPSERLTAPEILLHPWFE 259 >5X1R-A nrPDB Length = 302 Score = 122 bits (307), Expect = 2e-28, Method: Composition-based stats. Identities = 52/287 (18%), Positives = 94/287 (32%), Gaps = 28/287 (9%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVRE------- 56 + +E IG G +G VY+A D +A+K + L I E Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 57 ------VALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPP 110 + R L F HP ++ ++ + T + + L P Sbjct: 81 AGLNSFIQEARLLARFSHPGLLHVLRFWEENGTA-----YMGTQFYSGTTLKNLQAQQPE 135 Query: 111 GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLAR-IYSYQM 169 + I+ L+ ++ +H +HRD+ +NI + L DFG AR Sbjct: 136 KIDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPVLLDFGSARKEIGNLS 195 Query: 170 ALTPVVVTLWYRAPEVLLQSTYATP---VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKI 226 T +V+ + E +++ D++++G + + P + I Sbjct: 196 DETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP-----PVSVVRSI 250 Query: 227 FDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLL 273 D P + P S R P+ + A+LL Sbjct: 251 EDSYQ-PLTERRPAGYSPELLRTVDRALALKPEDRPQTIDEMAELLE 296 >5M07-A nrPDB Length = 276 Score = 119 bits (299), Expect = 1e-27, Method: Composition-based stats. Identities = 48/213 (22%), Positives = 84/213 (39%), Gaps = 28/213 (13%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y V +G A G VY + P + ALK + RE + RL Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADDE--FRRRFQRETEVAARL-- 87 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYLDKAPPPGLPAETIKDLMRQF 124 HP+++ + D R + + ++ + ++VD D ++ P LP + ++ Sbjct: 88 -FHPHILEVHD-----RGEFDGQLWIAMDYVDGIDATQHMADRFPAVLPVGEVLAIVTAV 141 Query: 125 LRGLDFLHANCIVHRDLKPENILVTS----GGTVKLADFGLARIYSYQMALTPVVVTLWY 180 LD+ H ++HRD+ P N+++TS + LADFG+A Y Sbjct: 142 AGALDYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ-------------PSY 188 Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPL 213 APE+ + D +++ +F P Sbjct: 189 PAPELSAGADVDGRADQYALALTAIHLFAGAPP 221 >3SV0-A nrPDB Length = 483 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 50/240 (20%), Positives = 90/240 (37%), Gaps = 31/240 (12%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 +++ +IG G++G +Y + + VA+K + E + R L Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIK-------LENVKTKHPQLLYESKIYRIL 59 Query: 64 EAFEH-PNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 + PN VR V LV + + L + L +T+ L Sbjct: 60 QGGTGIPN-VRWFGVEGDYN-------VLVMDLLGPSLEDLFN-FCSRKLSLKTVLMLAD 110 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSG---GTVKLADFGLARIYS--------YQMAL 171 Q + ++F+H+ +HRD+KP+N L+ G V + DFGLA+ Y Sbjct: 111 QMINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYREN 170 Query: 172 TPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCG---NSEADQLGKIFD 228 + T Y + L + D+ S+G + R + G ++ + KI + Sbjct: 171 KNLTGTARYASVNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISE 230 >5OAT-A nrPDB Length = 411 Score = 117 bits (294), Expect = 5e-27, Method: Composition-based stats. Identities = 68/318 (21%), Positives = 111/318 (34%), Gaps = 63/318 (19%) Query: 8 PVAEIGVGAYGTVYKARDPHS-----GHFVALKSVRVPNGGGGGGGLPISTVRE------ 56 I G G VY A+ + ALK + + + + RE Sbjct: 15 LGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRETVPARM 74 Query: 57 -----------VALLRRLEAFE-HPNVVRLMDVCAT------------SRTDREIKVTLV 92 + L R + HPN+V + V R + + L+ Sbjct: 75 YYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHPEGEGRNMSLFLL 134 Query: 93 FEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT--- 149 + D +L+++L AP + L+ G+ + A+ I HRDLK +N+L+ Sbjct: 135 MKRYDCNLQSFLSTAPSTRTSLLLLAQLL----EGVAHMTAHGIAHRDLKSDNLLLDTSE 190 Query: 150 -SGGTVKLADFGLA---RIYSYQMALTPV----VVTLWYRAPEVLLQST-------YATP 194 + ++DFG + + T APE++ Q Y+ Sbjct: 191 PESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYS-K 249 Query: 195 VDMWSVGCIFAEMFRRKPLFCGNSEADQLG-KIFDLIGLPPEDDWPRDVSLPRGAFPPRG 253 D+W+VG I E+F F G S K DL LP D+ P + R Sbjct: 250 ADLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGDLPKLP--DEVPTVIQALVANLLKRN 307 Query: 254 PRPVQSVVPEMEESGAQL 271 P + + PE+ + QL Sbjct: 308 PN--KRLDPEVAANVCQL 323 >5FQD-C nrPDB Length = 341 Score = 115 bits (289), Expect = 2e-26, Method: Composition-based stats. Identities = 46/218 (21%), Positives = 82/218 (37%), Gaps = 29/218 (13%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 + +Y+ V +IG G++G +Y A + +G VA+K + E L Sbjct: 16 IVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVK-------LESQKARHPQLLYESKLY 68 Query: 61 RRLEAFEH-PNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKD 119 + L+ P++ R + LV + + L + +T+ Sbjct: 69 KILQGGVGIPHI-RWYG-------QEKDYNVLVMDLLGPSLEDLFN-FCSRRFTMKTVLM 119 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTV---KLADFGLARIYSYQMAL----- 171 L Q + ++++H +HRD+KP+N L+ G L DFGLA+ Y Sbjct: 120 LADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPY 179 Query: 172 ---TPVVVTLWYRAPEVLLQSTYATPVDMWSVG-CIFA 205 + T Y + L + DM S+G + Sbjct: 180 REDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMY 217 >4TN6-A nrPDB Length = 318 Score = 114 bits (286), Expect = 5e-26, Method: Composition-based stats. Identities = 50/287 (17%), Positives = 98/287 (34%), Gaps = 32/287 (11%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRL 63 +RY +IG G++G +Y D +G VA+K + L I E + + + Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK---LECVKTKHPQLHI----ESKIYKMM 59 Query: 64 EAFEHPNVVRLMDVCATSRTDREIKV-TLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMR 122 + + + E +V E + L + +T+ L Sbjct: 60 QGG--------VGIPTIRWCGAEGDYNVMVMELLGPSLEDLFN-FCSRKFSLKTVLLLAD 110 Query: 123 QFLRGLDFLHANCIVHRDLKPENILV---TSGGTVKLADFGLARIYS--------YQMAL 171 Q + ++++H+ +HRD+KP+N L+ G V + DFGLA+ Y Sbjct: 111 QMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYREN 170 Query: 172 TPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCG---NSEADQLGKIFD 228 + T Y + L + D+ S+G + + G ++ + +I + Sbjct: 171 KNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISE 230 Query: 229 LIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEM 275 P + + + P+ QL + Sbjct: 231 KKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYS-YLRQLFRNL 276 >5X18-A nrPDB Length = 295 Score = 110 bits (275), Expect = 8e-25, Method: Composition-based stats. Identities = 53/285 (18%), Positives = 99/285 (34%), Gaps = 31/285 (10%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 Y+ +IG G++G +++ + +G VA+K E + L Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMINGVPVAIK-------FEPRKTEAPQLRDEYKTYKILN 60 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 PN+ A + LV + + L D +T+ + Q Sbjct: 61 GT--PNI-----PYAYYFGQEGLHNILVIDLLGPSLEDLFD-WCGRKFSVKTVVQVAVQM 112 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGT-----VKLADFGLARIYS--------YQMAL 171 + ++ LHA+ +++RD+KP+N L+ G + L DFG+A+ Y Sbjct: 113 ITLIEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREK 172 Query: 172 TPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCG---NSEADQLGKIFD 228 + T Y + L + DM ++G +F R + G + + KI + Sbjct: 173 KSLSGTARYMSINTHLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGE 232 Query: 229 LIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLL 273 D + + + G + P+ E LL Sbjct: 233 KKRSTNVYDLAQGLPVQFGRYLEIVRSLSFEECPDYEGYRKLLLS 277 >3REP-A nrPDB Length = 271 Score = 108 bits (270), Expect = 4e-24, Method: Composition-based stats. Identities = 49/272 (18%), Positives = 92/272 (33%), Gaps = 44/272 (16%) Query: 18 GTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDV 77 G ++K R G+ + +K ++V + E RL F HPNV+ ++ Sbjct: 24 GELWKGRW--QGNDIVVKVLKVRDWSTRKSRD----FNE--ECPRLRIFSHPNVLPVLGA 75 Query: 78 CATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANC-I 136 C + +T + L L + + RG+ FLH + Sbjct: 76 CQSPPAPHPTLITHWMPY--GSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPL 133 Query: 137 VHR-DLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYAT-- 193 + R L ++++ T +++ + + + APE L + T Sbjct: 134 IPRHALNSRSVMIDEDMTARIS----MADVKFSFQSPGRMYAPAWVAPEALQKKPEDTNR 189 Query: 194 -PVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPR 252 DMWS + E+ R+ F S + K+ L GL P Sbjct: 190 RSADMWSFAVLLWELVTREVPFADLSNMEIGMKVA-LEGLRP------------------ 230 Query: 253 GPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI 284 ++ P + ++L+ + +P KR Sbjct: 231 ------TIPPGISPHVSKLMKICMNEDPAKRP 256 >2C47-A nrPDB Length = 313 Score = 107 bits (267), Expect = 6e-24, Method: Composition-based stats. Identities = 51/289 (17%), Positives = 100/289 (34%), Gaps = 34/289 (11%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 + +IG G +G + ++ ++ +VA+K + + E ++L Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHL-------EYRFYKQLS 57 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 A E V C +V E + L D +T+ + Q Sbjct: 58 ATEGVPQVYYFGPCGKYNA-------MVLELLGPSLEDLFDLC-DRTFTLKTVLMIAIQL 109 Query: 125 LRGLDFLHANCIVHRDLKPENILVTSGGT-----VKLADFGLARIY--------SYQMAL 171 + ++++H +++RD+KPEN LV GT + + DFGLA+ Y Sbjct: 110 ITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREH 169 Query: 172 TPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCG---NSEADQLGKIFD 228 + T Y + L + D+ ++G +F R + G ++ ++ KI D Sbjct: 170 KSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGD 229 Query: 229 LIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPE---MEESGAQLLLE 274 P + + + R P+ + + L Sbjct: 230 TKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDR 278 >4NT4-A nrPDB Length = 312 Score = 107 bits (267), Expect = 7e-24, Method: Composition-based stats. Identities = 47/293 (16%), Positives = 96/293 (32%), Gaps = 30/293 (10%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 M + +IG G +G + ++ ++ VA+K R LL Sbjct: 9 MVGPNFRVGKKIGCGNFGELRLGKNLYNNEHVAIKM----EPMKSKAPQLHLEYRFYKLL 64 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 + R+ + +V E + L + +T+ + Sbjct: 65 GSHADNAPDGIPRIYHLGTCGGRYNA----MVLELLGLSLEDLFNICARK-FSLKTVLMI 119 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGT-----VKLADFGLARIY--------SY 167 +Q L ++++H+ +++RD+KPEN L+ T + + DFGLA+ Y Sbjct: 120 AKQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIP 179 Query: 168 QMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCG---NSEADQLG 224 + T Y + + + D+ ++G +F R + G ++ ++ Sbjct: 180 YREHKSLTGTARYMSINTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQ 239 Query: 225 KIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLT 277 KI D P + + R P+ L + Sbjct: 240 KIGDTKRATPIEVLCDGHPEEFATYLRYVRRLDFFETPDY-----DFLRRLFQ 287 >2CHL-A nrPDB Length = 351 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 49/294 (16%), Positives = 104/294 (35%), Gaps = 37/294 (12%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL 60 M + +IG G +G + ++ ++ +VA+K + L + E Sbjct: 27 MVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIK---LEPMKSRAPQLHL----EYRFY 79 Query: 61 RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 ++L + + V C +V E + L D +T+ + Sbjct: 80 KQLGSGDGIPQVYYFGPCGKYNA-------MVLELLGPSLEDLFDLC-DRTFSLKTVLMI 131 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVTSGGT-----VKLADFGLARIY--------SY 167 Q + ++++H+ +++RD+KPEN L+ G + + DF LA+ Y Sbjct: 132 AIQLISRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIP 191 Query: 168 QMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCG---NSEADQLG 224 + T Y + L + D+ ++G +F R + G ++ ++ Sbjct: 192 YREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQ 251 Query: 225 KIFDLIGLPPE----DDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLE 274 KI D P +++P + R + R + + + L Sbjct: 252 KIGDTKRATPIEVLCENFPEMATYLR--YVRRLDFFEKPDYDYLRKLFTDLFDR 303 >2CMW-A nrPDB Length = 310 Score = 104 bits (260), Expect = 4e-23, Method: Composition-based stats. Identities = 48/287 (16%), Positives = 96/287 (33%), Gaps = 33/287 (11%) Query: 7 EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF 66 +IG G +G + ++ ++ +VA+K + L +++ Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIK-LEPIKSRAPQLHLEYRFYKQLGSAGEGLPQ 61 Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLR 126 V C +V E + L D +T+ + Q L Sbjct: 62 -----VYYFGPCGKYNA-------MVLELLGPSLEDLFDLC-DRTFTLKTVLMIAIQLLS 108 Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVK-----LADFGLARIY--------SYQMALTP 173 ++++H+ +++RD+KPEN L+ G K + DFGLA+ Y Sbjct: 109 RMEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKS 168 Query: 174 VVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCG---NSEADQLGKIFDLI 230 + T Y + L + D+ ++G +F R + G ++ ++ KI D Sbjct: 169 LTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTK 228 Query: 231 GLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPE---MEESGAQLLLE 274 P + + + R P+ + L + Sbjct: 229 RNTPIEALCENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEK 275 >6EQI-C nrPDB Length = 433 Score = 103 bits (258), Expect = 8e-23, Method: Composition-based stats. Identities = 65/370 (17%), Positives = 116/370 (31%), Gaps = 100/370 (27%) Query: 4 SRYEPVAEIGVGAYGTVYKARDPHSG-----HFVALKSVRVPNGGGGGGGLPISTVRE-- 56 + I G VY A+ + H +A+K + + + + RE Sbjct: 15 DELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETV 74 Query: 57 -------------VALLR--RLEAFEHPNVVRLMDVCATSRTD----------------- 84 + + ++ HPN+VR+ V A D Sbjct: 75 PAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRIN 134 Query: 85 -----REIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHR 139 R + + LV + D L+ YL P + L+ Q L + ++ + I HR Sbjct: 135 PEGSGRNMSLFLVMKRYDCTLKEYLRDKTP---NMRSSILLLSQLLEAVAHMNIHNISHR 191 Query: 140 DLKPENILV-----TSGGTVKLADFGLARIYSYQMALTPVV-------VTLWYRAPEVLL 187 DLK +NILV + T+ + DFG + P APE+ Sbjct: 192 DLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIAN 251 Query: 188 QSTYA------TPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRD 241 D+W+VG I E+F F + Sbjct: 252 AKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKT----------------------- 288 Query: 242 VSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRI------SAFRA-LQHS- 293 + L ++ + +P + L+ ML+ + +KR+ + + L Sbjct: 289 MKLLSKSYKEEDLPELPDTIPFI---IRNLVSNMLSRSTNKRLDCDVAATVAQLYLWAPS 345 Query: 294 -YLHKDEGNP 302 +L ++ P Sbjct: 346 SWLKENYTLP 355 >4L00-A nrPDB Length = 304 Score = 102 bits (255), Expect = 2e-22, Method: Composition-based stats. Identities = 44/268 (16%), Positives = 89/268 (33%), Gaps = 47/268 (17%) Query: 25 DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTD 84 D + +K + + + ++ +++R++ H ++V L VC + Sbjct: 52 DEGTSEEKKIKVI-LKVLDPSHRDISLAFFEAASMMRQVS---HKHIVYLYGVCVRDVEN 107 Query: 85 REIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPE 144 +V E V+ L + +Q L +L +VH ++ + Sbjct: 108 -----IMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTK 162 Query: 145 NILVTSGGT-------VKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQST-YATPVD 196 N+L+ G +KL+D G+ + + + APE + S + D Sbjct: 163 NLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIP---WIAPECVEDSKNLSVAAD 219 Query: 197 MWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRP 256 WS G E+ + G E + + F RP Sbjct: 220 KWSFGTTLWEIC-----YNG------------------EIPLKDKTLIEKERFYESRCRP 256 Query: 257 VQSVVPEMEESGAQLLLEMLTFNPHKRI 284 V E+ A L+ + ++P++R Sbjct: 257 VTPSCKEL----ADLMTRCMNYDPNQRP 280 >1CSN-A nrPDB Length = 298 Score = 100 bits (249), Expect = 8e-22, Method: Composition-based stats. Identities = 47/290 (16%), Positives = 92/290 (31%), Gaps = 32/290 (11%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 Y+ IG G++G +++ + + VA+K R LL Sbjct: 11 HYKVGRRIGEGSFGVIFEGTNLLNNQQVAIK----FEPRRSDAPQLRDEYRTYKLLAGCT 66 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQF 124 PN V + LV + + L LD +T+ +Q Sbjct: 67 GI--PN-VYYFG-------QEGLHNVLVIDLLGPSLEDLLDLCGRK-FSVKTVAMAAKQM 115 Query: 125 LRGLDFLHANCIVHRDLKPENILV-----TSGGTVKLADFGLARIYS--------YQMAL 171 L + +H +V+RD+KP+N L+ + + + DFG+ + Y Sbjct: 116 LARVQSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREK 175 Query: 172 TPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCG---NSEADQLGKIFD 228 + T Y + L + D+ ++G +F R + G + + +I + Sbjct: 176 KNLSGTARYMSINTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGE 235 Query: 229 LIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTF 278 P + + P+ + L ++L Sbjct: 236 KKQSTPLRELCAGFPEEFYKYMHYARNLAFDATPDY-DYLQGLFSKVLER 284 >4L68-A nrPDB Length = 340 Score = 100 bits (249), Expect = 8e-22, Method: Composition-based stats. Identities = 42/201 (20%), Positives = 72/201 (35%), Gaps = 23/201 (11%) Query: 18 GTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDV 77 GT YKA G +A+K + G + +L H N+ L+ Sbjct: 54 GTTYKAL-LPDGSALAVKHLSTCKLGEREFRY---------EMNQLWELRHSNLAPLLGF 103 Query: 78 CATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANC-- 135 C LV++++ L + L T + RGL +LH C Sbjct: 104 CVVEEEK-----FLVYKYMSNGTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRP 158 Query: 136 -IVHRDLKPENILVTSGGTVKLADFGLARIYSYQMA-----LTPVVVTLWYRAPEVLLQS 189 I+H+++ IL+ ++ D GLAR+ +T + Y APE Sbjct: 159 PILHQNICSSVILIDEDFDARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEYSTTM 218 Query: 190 TYATPVDMWSVGCIFAEMFRR 210 + D++ +G + E+ Sbjct: 219 LASLKGDVYGLGVVLLELATG 239 >6J6I-B nrPDB Length = 351 Score = 98.4 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 44/227 (19%), Positives = 75/227 (33%), Gaps = 19/227 (8%) Query: 30 HFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKV 89 +K G + ++ L R+ H N ++L+ C Sbjct: 82 RSYMIKRFSEDEITGKRHRVK-EVYNDIVLSARMS--NHSNFLQLLGCCLEFPFP----- 133 Query: 90 TLVFEHVDQDLRT----YLDKAPPPGLPAETIKDLMRQFLRGLDFLHA---NCIVHRDLK 142 LVFE + + LP + ++ + +LH I+HRD+K Sbjct: 134 VLVFEFAEHGAMNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAFPKIIIHRDVK 193 Query: 143 PENILVTSGGTVKLADFGLARIYSYQMALTP---VVVTLWYRAPEVLLQSTYATPVDMWS 199 P ++ + T KL+D + + V+ T Y P D++S Sbjct: 194 PMHVFLDKNWTAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDPLYHKTCFVTEYTDVYS 253 Query: 200 VGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPR 246 G + KP S+ D L I L+ E+ +V PR Sbjct: 254 FGICLLVIITGKPAIMTISDGD-LQGILSLVRELCENGKLDEVIDPR 299 >5UV4-A nrPDB Length = 311 Score = 96.5 bits (239), Expect = 1e-20, Method: Composition-based stats. Identities = 52/212 (24%), Positives = 90/212 (42%), Gaps = 22/212 (10%) Query: 10 AEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHP 69 IG +GT YKA +G+ + +K ++ G RE+ ++L + HP Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLK-----EGFAKSKKEFSREI---KKLGSVRHP 81 Query: 70 NVVRLMDVCATSRTDREIKVTLVFEHVDQ-DLRTYL---DKAPPPGLPAETIKDLMRQFL 125 N+V L + I ++ ++ D L TYL D+ P L A ++ Sbjct: 82 NLVPLRGYYWGPKEHERI---MISDYADATSLSTYLSEFDERNLPPLSAGQRLNIAIDIA 138 Query: 126 RGLDFLHANCIV-HRDLKPENILV-TSGGTVKLADFGLARIYSYQMALTPVV--VTLWYR 181 R LD+LH ++ H ++K N+L+ S + + D+ L R+ + V+ L Y Sbjct: 139 RCLDYLHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYS 198 Query: 182 APEVLLQSTY--ATPVDMWSVGCIFAEMFRRK 211 PE S + D+++ G I E+ K Sbjct: 199 PPEFSSTSKPCPSLKSDVYAFGVILLELLTGK 230 >4XHH-A nrPDB Length = 403 Score = 95.7 bits (237), Expect = 2e-20, Method: Composition-based stats. Identities = 47/289 (16%), Positives = 100/289 (34%), Gaps = 34/289 (11%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 ++ +IG G++G +Y + SG VA+ R+ + L E + + L Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRHPQLDY----ESRVYKYLS 60 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVT-LVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 + + RE + +V + + L + +T+ L Q Sbjct: 61 GG--------VGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYC-HRKFSFKTVIMLALQ 111 Query: 124 FLRGLDFLHANCIVHRDLKPENILVT---SGGTVKLADFGLARIYS--------YQMALT 172 + + ++H +HRD+KP+N L+ G TV + DFGL++ Y Sbjct: 112 MICRVQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENK 171 Query: 173 PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCG---NSEADQLGKIFDL 229 + T Y + L + D+ S+G + + + G ++ + +I + Sbjct: 172 SLTGTARYASVNTHLGIEQSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEK 231 Query: 230 IGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPE---MEESGAQLLLEM 275 + + L + P+ + L +++ Sbjct: 232 KLCISVETLCAGLPLEFSEYMNYCRNLKFDERPDYLYLARLFKDLSIKL 280 >5USZ-A nrPDB Length = 289 Score = 95.0 bits (235), Expect = 4e-20, Method: Composition-based stats. Identities = 52/293 (17%), Positives = 90/293 (30%), Gaps = 61/293 (20%) Query: 10 AEIGVGAYGTVYKARDPHSGH-------FVALKSVRVPNGGGGGGGLPISTVREVALLRR 62 +G G + ++K G V LK + + S +++ + Sbjct: 14 ESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRN-----YSESFFEAASMMSK 68 Query: 63 LEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPAETIKDLM 121 L H ++V VC + LV E V L TYL K + ++ Sbjct: 69 LS---HKHLVLNYGVCVCGDEN-----ILVQEFVKFGSLDTYLKKNKNC-INILWKLEVA 119 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGT--------VKLADFGLARIYSYQMALTP 173 +Q + FL N ++H ++ +NIL+ +KL+D G++ + L Sbjct: 120 KQLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQE 179 Query: 174 VVVTLWYRAPEVLLQ-STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGL 232 + + PE + D WS G E+ G+ L L Sbjct: 180 RIP---WVPPECIENPKNLNLATDKWSFGTTLWEICSG-----GDKPLSALDSQRKLQFY 231 Query: 233 PPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRIS 285 P P+ E L+ + + P R S Sbjct: 232 EDRHQLPA---------------------PKAAELA-NLINNCMDYEPDHRPS 262 >4XHL-A nrPDB Length = 394 Score = 94.6 bits (234), Expect = 4e-20, Method: Composition-based stats. Identities = 48/289 (16%), Positives = 99/289 (34%), Gaps = 34/289 (11%) Query: 5 RYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE 64 ++ +IG G++G +Y + SG VA+ R+ + L E + R L Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAI---RLESIRSRHPQLDY----ESRVYRYLS 60 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVT-LVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQ 123 + + RE + +V + + L + +T+ L Q Sbjct: 61 GG--------VGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYC-HRRFSFKTVIMLALQ 111 Query: 124 FLRGLDFLHANCIVHRDLKPENILVT---SGGTVKLADFGLARIYS--------YQMALT 172 + ++H +HRD+KP+N L+ G TV + DFGL++ Y Sbjct: 112 MFCRIQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENK 171 Query: 173 PVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCG---NSEADQLGKIFDL 229 + T Y + L + D+ S+G + + + G ++ + +I + Sbjct: 172 SLTGTARYASVNTHLGIEQSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEK 231 Query: 230 IGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPE---MEESGAQLLLEM 275 + + L + P+ + L +++ Sbjct: 232 KLNVSVETLCSGLPLEFQEYMAYCKNLKFDEKPDYLFLARLFKDLSIKL 280 >5C01-A nrPDB Length = 342 Score = 93.8 bits (232), Expect = 8e-20, Method: Composition-based stats. Identities = 49/279 (17%), Positives = 90/279 (32%), Gaps = 54/279 (19%) Query: 23 ARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSR 82 RD V LK + + +++ + H ++ + VC Sbjct: 101 GRDRGQELRVVLKVLDPSHHDIALAFYETASL--------MSQVSHTHLAFVHGVCVRGP 152 Query: 83 TDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLK 142 + +V E+V+ + +P + +Q L +L +VH ++ Sbjct: 153 EN-----IMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVC 207 Query: 143 PENILVTSGGT-------VKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQS--TYAT 193 NIL+ G +KL+D G+ + + + APE L + +T Sbjct: 208 GRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP---WLAPECLPGGANSLST 264 Query: 194 PVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPR 252 +D W G E+ F + S ++ E + R LP + P Sbjct: 265 AMDKWGFGATLLEICFDGEAPLQSRSPSE------------KEHFYQRQHRLPEPSCPQ- 311 Query: 253 GPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 A L + LT+ P +R S L+ Sbjct: 312 ---------------LATLTSQCLTYEPTQRPSFRTILR 335 >4WOV-A nrPDB Length = 317 Score = 93.0 bits (230), Expect = 1e-19, Method: Composition-based stats. Identities = 49/279 (17%), Positives = 90/279 (32%), Gaps = 54/279 (19%) Query: 23 ARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSR 82 RD V LK + + +++ + H ++ + VC Sbjct: 78 GRDRGQELRVVLKVLDPSHHDIALAFYETASL--------MSQVSHTHLAFVHGVCVRGP 129 Query: 83 TDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLK 142 + +V E+V+ + +P + +Q L +L +VH ++ Sbjct: 130 EN-----IMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVC 184 Query: 143 PENILVTSGGT-------VKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQS--TYAT 193 NIL+ G +KL+D G+ + + + APE L + +T Sbjct: 185 GRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIP---WLAPECLPGGANSLST 241 Query: 194 PVDMWSVGCIFAEM-FRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPR 252 +D W G E+ F + S ++ E + R LP + P Sbjct: 242 AMDKWGFGATLLEICFDGEAPLQSRSPSE------------KEHFYQRQHRLPEPSCPQ- 288 Query: 253 GPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 A L + LT+ P +R S L+ Sbjct: 289 ---------------LATLTSQCLTYEPTQRPSFRTILR 312 >4I94-A nrPDB Length = 300 Score = 91.5 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 37/268 (13%), Positives = 77/268 (28%), Gaps = 40/268 (14%) Query: 19 TVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVC 78 VYK + + +A+K + + E + +L N L+ C Sbjct: 44 VVYKGK-LENQRRIAVKRFNRKSWPDSR-----QFLEEAKAVGQLRNHRMAN---LLGCC 94 Query: 79 ATSRTDREIKVTLVFEHVDQD-LRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANC-I 136 L+ E + + L +L + + + L++ + Sbjct: 95 YEDEER-----LLIAEFMPNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRA 149 Query: 137 VHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVD 196 ++ DL +L +L+ FGL + + + L + PE L Sbjct: 150 LYHDLNAYRVLFDDDANPRLSCFGLMKNSRDGKSYSTN---LAFTPPEYLRTGRVTPESV 206 Query: 197 MWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRP 256 ++S G + ++ K + ++ L I D R Sbjct: 207 IYSFGTLLLDLLSGKHIPPSHA----LDLIRD-----------------RNIQMLMDSGL 245 Query: 257 VQSVVPEMEESGAQLLLEMLTFNPHKRI 284 + +L L + P +R Sbjct: 246 EGQFSSDDGTELIRLASRCLQYEPRERP 273 >5UU1-A nrPDB Length = 324 Score = 82.3 bits (202), Expect = 2e-16, Method: Composition-based stats. Identities = 42/236 (17%), Positives = 80/236 (33%), Gaps = 25/236 (10%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVA-- 58 M +++ +IG G +G +Y A + A V+V G + + VA Sbjct: 13 MEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHVVKVEYQENGPLFSELKFYQRVAKK 72 Query: 59 -------LLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPG 111 ++L+ + L + +V E + DL+ Sbjct: 73 DCIKKWIERKQLDYLG----IPLFYGSGLTEFKGRSYRFMVMERLGIDLQKI--SGQNGT 126 Query: 112 LPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILV--TSGGTVKLADFGLA------- 162 T+ L + L L+++H N VH D+K N+L+ + V LAD+GL+ Sbjct: 127 FKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCPNG 186 Query: 163 -RIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGN 217 + T+ + + + + D+ +G K + N Sbjct: 187 NHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQN 242 >2RSV-A nrPDB Length = 403 Score = 80.3 bits (197), Expect = 9e-16, Method: Composition-based stats. Identities = 51/297 (17%), Positives = 106/297 (35%), Gaps = 25/297 (8%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFV---ALKSVRVPNGGGGGGGLPISTVREV 57 MA ++ IG G +G +Y A D +S V A V+V G + + Sbjct: 39 MAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 97 Query: 58 ALLRRLEAFEHPNVVRLMDV---CATSRTDREIKVT--LVFEHVDQDLRTYLDKAPPPGL 112 A +++ + ++ + V + D+ K ++ + DL+ + +A Sbjct: 98 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQK-IYEANAKRF 156 Query: 113 PAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT--SGGTVKLADFGLARIYSYQMA 170 +T+ L + L L+++H + VH D+K N+L+ + V L D+GLA Y + Sbjct: 157 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGV 216 Query: 171 LTPVV--------VTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGN----- 217 T+ + + + + D+ +G + + N Sbjct: 217 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 276 Query: 218 SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLE 274 D + + I + +P A + + + E+ +LL+ Sbjct: 277 YVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQ 333 >5CLR-A nrPDB Length = 451 Score = 79.9 bits (196), Expect = 1e-15, Method: Composition-based stats. Identities = 38/195 (19%), Positives = 68/195 (34%), Gaps = 25/195 (12%) Query: 21 YKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCAT 80 +K G LKSV++ E L +L RL+ Sbjct: 96 FKVYALDDGKTYFLKSVKIDAESLT------EFTNEKDTLSKLG--------RLVGTFFN 141 Query: 81 SRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAET---IKDLMRQFLRGLDFLHANCIV 137 +T ++ + + A P + + + +M + H ++ Sbjct: 142 EQTQVH---YILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLI 198 Query: 138 HRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQST---YATP 194 HRDLKP NI++ + L DFG + S + T Y APE+ Q ++ Sbjct: 199 HRDLKPGNIMLDADMQCHLVDFGSSS--SDKEPKPASWGTASYLAPELNAQEDFIAFSQV 256 Query: 195 VDMWSVGCIFAEMFR 209 D++++ E+F Sbjct: 257 SDLFALAYSLDELFN 271 >2LAV-A nrPDB Length = 361 Score = 79.2 bits (194), Expect = 2e-15, Method: Composition-based stats. Identities = 51/297 (17%), Positives = 106/297 (35%), Gaps = 25/297 (8%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFV---ALKSVRVPNGGGGGGGLPISTVREV 57 MA ++ IG G +G +Y A D +S V A V+V G + + Sbjct: 32 MAKKEWKVGLPIGQGGFGCIYLA-DMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRA 90 Query: 58 ALLRRLEAFEHPNVVRLMDV---CATSRTDREIKVT--LVFEHVDQDLRTYLDKAPPPGL 112 A +++ + ++ + V + D+ K ++ + DL+ + +A Sbjct: 91 AKPEQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQK-IYEANAKRF 149 Query: 113 PAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT--SGGTVKLADFGLARIYSYQMA 170 +T+ L + L L+++H + VH D+K N+L+ + V L D+GLA Y + Sbjct: 150 SRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYGLAYRYCPEGV 209 Query: 171 LTPVV--------VTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGN----- 217 T+ + + + + D+ +G + + N Sbjct: 210 HKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILGYCMIQWLTGHLPWEDNLKDPK 269 Query: 218 SEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLE 274 D + + I + +P A + + + E+ +LL+ Sbjct: 270 YVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKLLDYTEKPLYENLRDILLQ 326 >4IX6-A nrPDB Length = 350 Score = 78.0 bits (191), Expect = 5e-15, Method: Composition-based stats. Identities = 56/340 (16%), Positives = 96/340 (28%), Gaps = 81/340 (23%) Query: 10 AEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHP 69 +G G +GTV++ V + E+ ++ H Sbjct: 26 GPLGSGNFGTVFRGVFKGDQDVV-----------LKNAKADVMAAEELLEC-EMDVNYHV 73 Query: 70 N------VVRLMDVCATSRTDREIKVT-------LVFEHVDQDLRTYLDKAPPPGLPAET 116 + R M C ++ L ++ T P T Sbjct: 74 HANAKGTCARFMG-CIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLAT 132 Query: 117 I------------KDLMRQFLRGLDFLHANCIVHRDLKPENILVTS--GGTVKLADFGLA 162 K MR+ L L LH +VHRD+KP N++ GG +KL D G A Sbjct: 133 AMACADATELGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAA 192 Query: 163 RI---YSYQMALTPVVVT--LWY--------RAP--------------EVLLQSTYATPV 195 + + P Y P E + + Sbjct: 193 ALCLPLPETLNYYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDS-- 250 Query: 196 DMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR 255 WS GC+ ++ ++ ++ + +G DV+ RG Sbjct: 251 --WSAGCVMLQLAVVG--LRTDAGLERFLADYKAVGY--------DVNAFRGEKSGEYGT 298 Query: 256 PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYL 295 + + +G L ++ R S AL H++ Sbjct: 299 MDFAALDANGGAGWDLCQRLMEAERDARASCEAALSHAFF 338 >6EAS-A nrPDB Length = 308 Score = 71.9 bits (175), Expect = 4e-13, Method: Composition-based stats. Identities = 36/274 (13%), Positives = 78/274 (28%), Gaps = 39/274 (14%) Query: 21 YKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCAT 80 YK SG +A+ S V + +++ L ++ H N + L+ C Sbjct: 57 YKGT-LSSGVEIAVASSLVTSAKDWSKENESQYRKKITNLSKVS---HKNFMNLLGYCEE 112 Query: 81 SRTDREIKVTLVFEHV-DQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCI--V 137 +VFE+ + L +L L + L+ +H Sbjct: 113 EHPFTR---VMVFEYAPNGTLFEHLHVREAEKLDWMARLRISMGIAYCLEHMHQLQTPAA 169 Query: 138 HRDLKPENILVTSGGTVKLADFGLARIYSYQMALTP--VVVTLWYRAPEVLLQSTYATPV 195 R+ + +T K++D + T + + E +++ Sbjct: 170 LRNFDSTTVYLTDDFAAKVSDLEFWNDAKGHNSTTNNELAFSPDM---EDIVRK------ 220 Query: 196 DMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPR 255 G + E+ + +SE D P ++W Sbjct: 221 ----YGMVLLEILTGRVP---SSEDD-----------GPLENWVSRYFEGGMRLEELIDP 262 Query: 256 PVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 + + + +++ + +P KR Sbjct: 263 SIGFFPEDTARALCEVVRSCIDRDPKKRPQMKEV 296 >5DMZ-A nrPDB Length = 365 Score = 71.5 bits (174), Expect = 4e-13, Method: Composition-based stats. Identities = 50/302 (16%), Positives = 94/302 (31%), Gaps = 52/302 (17%) Query: 12 IGVGAYGTVYKAR-----DPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLE-A 65 +G GA+ VY+A D + LK + N G L+ RL+ + Sbjct: 73 LGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGT--------QLMERLKPS 124 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLR----TYLDKAPPPGLPAETIKDLM 121 +H ++ LV E P +P + Sbjct: 125 MQHMF-MKFYSAHLFQNGS-----VLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFA 178 Query: 122 RQFLRGLDFLHANCIVHRDLKPENILVTSGGT-----------VKLADFGLA---RIYSY 167 + L ++ +H I+H D+KP+N ++ +G + L D G + +++ Sbjct: 179 MRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPK 238 Query: 168 QMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRR--------------KPL 213 T T ++ E+L + +D + V M + L Sbjct: 239 GTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGL 298 Query: 214 FCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLL 273 F D + F ++ P+ + L R + + + + LLL Sbjct: 299 FRRLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLL 358 Query: 274 EM 275 E Sbjct: 359 EC 360 >4CI6-B nrPDB Length = 643 Score = 70.3 bits (171), Expect = 1e-12, Method: Composition-based stats. Identities = 49/260 (18%), Positives = 93/260 (35%), Gaps = 31/260 (11%) Query: 56 EVALLRRLEAF--EHPNVVRLMDVCATSRTDREIKVTLVFE----HVDQDLRTYLDKAPP 109 E+ + + +HPN+ + + +R L+ E LR+ D Sbjct: 87 ELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRYYYALLMDEVDGWRCSDTLRSLADSWKQ 146 Query: 110 PGLPAE----TIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARI 164 + +E TIK + + L + L IVH D+KP N++ + G + D GL Sbjct: 147 GKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGL--- 203 Query: 165 YSYQMALTPVVVTLWYRAPEV-LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQL 223 + P T ++APE+ + + D++ L G ++ Sbjct: 204 -HSRSGEQPKGFTESFKAPELGVGNLGASEKSDVF---------LVVSTLLHGIEGFEKD 253 Query: 224 GKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKR 283 +I GL P V + +P P + +E + + + ++L + R Sbjct: 254 PEIKPNQGLRFITSEPAHV-MDENGYPIHRP-----GIAGVETAYTRFITDILGVSADSR 307 Query: 284 ISAFRALQHSYLHKDEGNPE 303 + A H +L + E Sbjct: 308 PDSNEARLHEFLSDGTIDEE 327 >2JII-A nrPDB Length = 352 Score = 64.5 bits (156), Expect = 6e-11, Method: Composition-based stats. Identities = 42/224 (18%), Positives = 79/224 (35%), Gaps = 21/224 (9%) Query: 78 CATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIV 137 C ++ LV + + L++ LD +P L ++ + + L L+FLH N V Sbjct: 122 CMGFGVHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYV 181 Query: 138 HRDLKPENILVT--SGGTVKLADFGLARIYSYQMALTPVV--------VTLWYRAPEVLL 187 H ++ ENI V V LA +G A Y V L + + ++ Sbjct: 182 HGNVTAENIFVDPEDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHK 241 Query: 188 QSTYATPVDMWSVGCIFAEMFRRKPLF--CGNSEADQLGKIFDLIGLPPEDDWPRDVSLP 245 + D+ S+G + + C + D + + + P P + Sbjct: 242 GCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIR 301 Query: 246 RGAFPPRGPRPVQSVVPEMEESGAQL---LLEMLT------FNP 280 + + V ++ E + A L L +L ++P Sbjct: 302 PSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVSPYDP 345 >4O1O-A nrPDB Length = 717 Score = 62.2 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 28/133 (21%), Positives = 50/133 (37%), Gaps = 19/133 (14%) Query: 30 HFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKV 89 VA+K + G + + R + NVV + + V Sbjct: 370 QEVAVKRFSEGSTRGQQEVSCLQSSR-----------ANDNVVTFYGSESDGSC---LHV 415 Query: 90 TLVFEHVDQDLRTYLDKAPPPGLPAET---IKDLMRQFLRGLDFLHANCIVHRDLKPENI 146 L + L+ +L +P E ++++ + + LH + H+DL+P+NI Sbjct: 416 CLA--LCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNI 473 Query: 147 LVTSGGTVKLADF 159 L+ S LADF Sbjct: 474 LIDSKNGTFLADF 486 >6G4J-A nrPDB Length = 315 Score = 62.2 bits (150), Expect = 3e-10, Method: Composition-based stats. Identities = 52/235 (22%), Positives = 75/235 (31%), Gaps = 38/235 (16%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA 65 Y ++G GA G VY A + GH VALK +S EV +L+ Sbjct: 28 YTLRKQLGKGANGIVYLA-ETSDGH-VALKV----------SDDSLSITSEVNVLKSFSK 75 Query: 66 FEH----PNVVRLMDVCATSRTDREIKV-TLVFEHVDQDLRTYLDKAPPPGLPAETIKDL 120 + P D KV E++ L E I L Sbjct: 76 AQSVTMGP---SFFDTDDAYIPSANTKVSFYAMEYIKGPLLLKYVSDKGA----EWIPVL 128 Query: 121 MRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALTPVVVTLW 179 M Q L L LH + DLKP+N++VT ++ D G + Sbjct: 129 MIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVGGTTKEGRAIKEYTEFYDRG 188 Query: 180 YRAPEVLLQSTYAT-----PVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDL 229 Y Y T D+++V I +K N +QL + + Sbjct: 189 Y--------WGYGTRKAEPSYDLFAVAMIMINSVHKKEFKKTNQPKEQLRSLIEG 235 >4CYJ-A nrPDB Length = 438 Score = 61.5 bits (148), Expect = 4e-10, Method: Composition-based stats. Identities = 31/155 (20%), Positives = 64/155 (41%), Gaps = 25/155 (16%) Query: 17 YGT---VYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVR 73 +G VYKA++ +G AL+ + L +++ + ++ ++V Sbjct: 65 FGYPSWVYKAQNSRNGRHYALRRLEGYRLTNEKAIL--------NVMKDWKKIKNASIVT 116 Query: 74 LMDVCATSRTDREIKVTLVFEH----VDQDLRTYL-------DKAPPPGLPAETIKDLMR 122 + +V T L+F + + + L+ + PPP +P TI + Sbjct: 117 IHEVFTTREFGDSS---LIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYIC 173 Query: 123 QFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLA 157 Q L +H+N + R L+P I++T ++L+ Sbjct: 174 QIANALKTIHSNRLAARCLEPSKIILTDINRIRLS 208 >6BHC-A nrPDB Length = 438 Score = 61.1 bits (147), Expect = 6e-10, Method: Composition-based stats. Identities = 58/295 (19%), Positives = 90/295 (30%), Gaps = 69/295 (23%) Query: 31 FVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA-FEH-----PNVVRLMDVCATSRTD 84 A+K + ++ + +A+ ++ H PN RL+ S+ Sbjct: 85 NYAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPN--RLLPWEDPSKKQ 142 Query: 85 REIKVTL--------VFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCI 136 R V + V + V L + P L + L+ Q GL+ L + Sbjct: 143 RSHVVVITREVPCLTVADFVRDSLAQH---GKSPDLYERQVCLLLLQLCSGLEHLKPYHV 199 Query: 137 VHRDLKPENILVTS---GGTVKLADFGLARIYSYQMALTPVVVT-------------LWY 180 H DL+ EN+L+ GGT + FG A T ++V+ Sbjct: 200 THCDLRLENLLLVHYQPGGTAQ--GFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEI 257 Query: 181 ------RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPP 234 APE++ + Y D + G + EM F N P Sbjct: 258 LRDQSRLAPEIITATQY-KKCDEFQTGILIYEMLHLPNPFDEN----------------P 300 Query: 235 EDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRA 289 E P R P QL +L NP +RI A Sbjct: 301 ELKEREYTRADLPRIPFRSPY---------SRGLQQLASCLLNPNPSERILISDA 346 >6EWX-A nrPDB Length = 484 Score = 59.1 bits (142), Expect = 2e-09, Method: Composition-based stats. Identities = 37/226 (16%), Positives = 64/226 (28%), Gaps = 67/226 (29%) Query: 107 APPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGG-------------- 152 P + + L+ Q GL+ L + I+HRDL EN+L+ Sbjct: 202 RAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSVP 261 Query: 153 ---------------------------TVKLADFGLARIYSYQMALTPVVVTLWYRAPEV 185 + +++F A+ + APE+ Sbjct: 262 TTTSRCPSAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPEI 321 Query: 186 LLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLP 245 + S Y D + G + E+ + F ++ R+ Sbjct: 322 VSASQY-RKFDEFQTGILIYELLHQPNPFEVRAQL-------------------RERDYR 361 Query: 246 RGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 R PP + QL +L +P KRI A + Sbjct: 362 REDLPPLPTLSLY------SPGLQQLAHLLLEADPIKRIRIGEAKR 401 >6M7Z-A nrPDB Length = 319 Score = 57.6 bits (138), Expect = 6e-09, Method: Composition-based stats. Identities = 35/228 (15%), Positives = 66/228 (28%), Gaps = 63/228 (27%) Query: 85 REIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPE 144 R +T +F + + L + + ++ L + L LH ++HR ++ Sbjct: 117 RGAFLTYIFHPLSKGLVGDMLETGR---SHPDVQVLAANMVAALKSLHNLGLLHRSIELN 173 Query: 145 NILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYR-------APEV---------LLQ 188 + V GTV L A + T + APE+ L Q Sbjct: 174 SFSVLPDGTVVLGGLDTAAPIGTE--------TRLWVGFFGQETAPEIDRNFLADLALTQ 225 Query: 189 STYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGA 248 + D++S+G + L+G G Sbjct: 226 GRHTVKSDVYSLGV-------------------AFRNLVQLLG--------------NGN 252 Query: 249 FPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLH 296 P V+ E+ + L +M+ P R + ++ Sbjct: 253 LGPEDRGAVRQDHLELLDK---LSQKMIEEEPGNRPTIEEIMKDPLFE 297 >4OAU-C nrPDB Length = 699 Score = 57.6 bits (138), Expect = 7e-09, Method: Composition-based stats. Identities = 28/135 (20%), Positives = 48/135 (35%), Gaps = 20/135 (14%) Query: 29 GHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIK 88 VA+K+ REV+ L+ H +V Sbjct: 366 KQEVAVKTF---------CEGSPRAQREVSCLQSSRENSH--LVTFYG-----SESHRGH 409 Query: 89 VTLVFEHVDQDLRTYLDKAPPPGLPAET---IKDLMRQFLRGLDFLH-ANCIVHRDLKPE 144 + + +Q L LD + E ++++ + + LH + H+DL+P+ Sbjct: 410 LFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQ 469 Query: 145 NILVTSGGTVKLADF 159 NIL+ S LADF Sbjct: 470 NILIDSKKAAHLADF 484 >5GZ9-A nrPDB Length = 305 Score = 51.8 bits (123), Expect = 3e-07, Method: Composition-based stats. Identities = 33/200 (16%), Positives = 67/200 (33%), Gaps = 41/200 (20%) Query: 33 ALKSVRVPNGGGGGGGLPISTVREVAL-----LRRLEAFEHPNVVRLMDVCATSRTDREI 87 A+K V + L T E+ L+ L++ + +VV L+ C T Sbjct: 46 AVKRVFLSEWKEHKVALSRLTRLEMKEDFLHGLQMLKSLQSEHVVTLVGYCEEDGT---- 101 Query: 88 KVTLVFEHVDQDLRTYLDKAPPPG-----LPAETIKDLMRQFLRGLDFLHANCIVHRDLK 142 ++ E+ + L++ + L +++ +++LH + + R + Sbjct: 102 ---ILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLAMEYVSIINYLHHSPLGTRVMC 158 Query: 143 PEN--------ILVTSGGTVKLADFGLARIYSYQMALTPVVVTLW----YRAPEVL---- 186 N L+TS ++ D + + + + APE L Sbjct: 159 DSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLIKCGHRELHGDFVAPEQLWPYG 218 Query: 187 --------LQSTYATPVDMW 198 L +Y VD+W Sbjct: 219 EDTPFQDDLMPSYNEKVDIW 238 >4AZV-A nrPDB Length = 569 Score = 51.1 bits (121), Expect = 6e-07, Method: Composition-based stats. Identities = 18/71 (25%), Positives = 30/71 (42%), Gaps = 4/71 (5%) Query: 90 TLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT 149 LV E + L + + A + ++ LR L L H D++P N++V Sbjct: 318 WLVMEKLPGRLLSDMLAAGE----EIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMVD 373 Query: 150 SGGTVKLADFG 160 + +L DFG Sbjct: 374 ARQHARLIDFG 384 >4AZW-A nrPDB Length = 471 Score = 50.7 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 18/71 (25%), Positives = 30/71 (42%), Gaps = 4/71 (5%) Query: 90 TLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVT 149 LV E + L + + A + ++ LR L L H D++P N++V Sbjct: 318 WLVMEKLPGRLLSDMLAAGE----EIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVD 373 Query: 150 SGGTVKLADFG 160 + +L DFG Sbjct: 374 ARQHARLIDFG 384 >6G38-A nrPDB Length = 357 Score = 49.1 bits (116), Expect = 3e-06, Method: Composition-based stats. Identities = 31/183 (16%), Positives = 57/183 (31%), Gaps = 43/183 (23%) Query: 1 MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVR---EV 57 + T + + +IG G +G V++ H+ VA+K + + G + E+ Sbjct: 38 LPTEKLQRCEKIGEGVFGEVFQTIADHT--PVAIKIIAIEGPDLVNGSHQKTFEEILPEI 95 Query: 58 ALLRRLEAFEHP-----------NVVR---------LMDVCATSRT-------------D 84 + + L N V L+ + D Sbjct: 96 IISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKD 155 Query: 85 REIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLH-ANCIVHRDLKP 143 ++ + L FE DL ++ T K ++ Q L + HRDL Sbjct: 156 DQLFIVLEFEFGGIDL----EQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHW 211 Query: 144 ENI 146 N+ Sbjct: 212 GNV 214 >4BWP-A nrPDB Length = 448 Score = 48.7 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 32/172 (18%), Positives = 61/172 (35%), Gaps = 44/172 (25%) Query: 21 YKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCAT 80 Y+A +G+ L+ + G + + + + L+ + +H NVV+L +V T Sbjct: 67 YRATHNTTGYKYCLRRI---------HGFRLQSTKCMTLVEMWKKLQHTNVVQLREVFTT 117 Query: 81 SRTDREIKVTLVFEHVDQD---LRTYL---------------------------DKAPPP 110 + + + LV+++ L Y + P Sbjct: 118 -KAFGDNSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGP 176 Query: 111 GLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGT----VKLAD 158 LP TI ++ Q GL +H + + L P I+VT ++D Sbjct: 177 LLPEATIWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVRFSSCCISD 228 >3Q60-A nrPDB Length = 371 Score = 48.4 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 28/184 (15%), Positives = 59/184 (32%), Gaps = 22/184 (11%) Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLW 179 L Q +R L + +VH P+N+ + G + L D ++ ++ V + Sbjct: 199 LTAQLIRLAANLQSKGLVHGHFTPDNLFIMPDGRLMLGD--VSALWKVGTRGPASSVPVT 256 Query: 180 YRAPEVLL--QSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 237 Y E L +T+ ++ W +G ++ F + G+ Sbjct: 257 YAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPFGLVTP-----------GIKGSWK 305 Query: 238 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 297 P + P+ V L+ L F+ +R+ A++ + Sbjct: 306 RPSLRVPGTDSLAFGSCTPLPDFVKT-------LIGRFLNFDRRRRLLPLEAMETPEFLQ 358 Query: 298 DEGN 301 + Sbjct: 359 LQNE 362 >5GZA-A nrPDB Length = 290 Score = 48.0 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 43/223 (19%), Positives = 62/223 (27%), Gaps = 53/223 (23%) Query: 7 EPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAF 66 V IG GA VY + G VAL + L L A Sbjct: 28 RRVKLIGQGAVKKVYLSEW--QGQKVALSVLSSDQYADDFLHG----------LSMLRAL 75 Query: 67 EHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLD-----KAPPPGLPAETIKDLM 121 + +VV L+ VC V E+ LD + T L Sbjct: 76 QSSHVVTLVGVCEEDA-------VFVTEYHPLGSVLTLDTTLAQERYRWRNSWHTRLQLA 128 Query: 122 RQFLRGLDFLHA----------NCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL 171 ++ L +LH+ + +H+ L L+ S + D A + L Sbjct: 129 IDYVAFLAYLHSSPAGIRVMCDSNDLHKTL--SQFLLASDMRLLANDLD-ALPEVEKGGL 185 Query: 172 TPVVV----TLWYRAPEVL------------LQSTYATPVDMW 198 T + APE L Y D+W Sbjct: 186 GVKCGHHELTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW 228 >3BYV-A nrPDB Length = 377 Score = 47.6 bits (112), Expect = 6e-06, Method: Composition-based stats. Identities = 36/217 (16%), Positives = 71/217 (32%), Gaps = 36/217 (16%) Query: 22 KARDPHSGHFV--------------ALKSVRVPNGGGGGGGLPISTVREVALLRRL---E 64 +A D +G A+K ++ + + LR + + Sbjct: 91 EATDQETGESFEVHVPYFTERPPSNAIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFD 150 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTY-----LDKAPPPGLPAETIKD 119 + P +++ V R + ++ + +L+T+ + L Sbjct: 151 LVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQ 210 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLW 179 L Q +R L LH +VH L+P +I++ G V L F A V+ Sbjct: 211 LTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGF---EHLVRDGARVVSSVSRG 267 Query: 180 YRAPEVLLQS---TY--------ATPVDMWSVGCIFA 205 + PE+ + +Y D W++G + Sbjct: 268 FEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIY 304 >3ENH-A nrPDB Length = 540 Score = 47.6 bits (112), Expect = 7e-06, Method: Composition-based stats. Identities = 31/165 (18%), Positives = 58/165 (35%), Gaps = 28/165 (16%) Query: 12 IGVGAYGTVYKARDPHSGHFVALK-SVRV--PNGGGGGGGLPISTVREVALLRRLEAFE- 67 IG GA + RD + V +K V+ + T RE L ++ F Sbjct: 344 IGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFGI 401 Query: 68 -HPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLR 126 P + DV ++ ++ +++ L + + D+ + Sbjct: 402 PAPYI---FDVDLDNKR-------IMMSYINGKLAKDVIEDN---------LDIAYKIGE 442 Query: 127 GLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMAL 171 + LH N ++H DL N + + + DFGL +I + Sbjct: 443 IVGKLHKNDVIHNDLTTSNFIFDKD--LYIIDFGLGKISNLDEDK 485 >4CZY-B nrPDB Length = 429 Score = 46.8 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 41/276 (14%), Positives = 84/276 (30%), Gaps = 45/276 (16%) Query: 21 YKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCAT 80 YKA++ +G AL+ + L ++ + + + N+V + + T Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLTNEKAILNVT--------KEWKKIINANIVTVHEAFTT 112 Query: 81 SRTDREIKVTLVFEH--VDQDLRTYL--------DKAPPPGLPAETIKDLMRQFLRGLDF 130 + + V++ + + L + +P + + Q L Sbjct: 113 -EFFGDSSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLA 171 Query: 131 LHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQST 190 +H + R L+ I + ++LA I +P T+ E L Q Sbjct: 172 IHNAKLAARCLELSKI-IWENNRIRLA---ACSILDVLHHDSPNRKTI-----EELQQED 222 Query: 191 YATPVDMWSVGCIFAEMFRRKPLFCGNS-----------EADQLGKIFDLIGLPPEDDWP 239 + G I + P N+ + QL + + + P Sbjct: 223 FVK------FGRIILALATNTPTLNFNNIDAALATIVPRYSTQLRGVLEWLIKPSAPGET 276 Query: 240 RDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEM 275 + V G V+ E +E L+ E+ Sbjct: 277 KTVETLLGGITTHLANFANFVMQESDEKEFHLMREL 312 >5VE6-A nrPDB Length = 492 Score = 45.7 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 13/37 (35%), Positives = 20/37 (54%) Query: 114 AETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTS 150 + L+ Q GL+ L + I+HRDL EN+L+ Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVH 243 Score = 39.9 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 20/111 (18%), Positives = 34/111 (30%), Gaps = 26/111 (23%) Query: 181 RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR 240 APE++ S Y D + G + E+ + F ++ R Sbjct: 325 LAPEIVSASQY-RKFDEFQTGILIYELLHQPNPFEVRAQL-------------------R 364 Query: 241 DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQ 291 + + PP + QL +L +P KRI A + Sbjct: 365 ERDYRQEDLPPLPALSLY------SPGLQQLAHLLLEADPIKRIRIGEAKR 409 >4WWA-A nrPDB Length = 261 Score = 45.7 bits (107), Expect = 2e-05, Method: Composition-based stats. Identities = 32/157 (20%), Positives = 50/157 (31%), Gaps = 25/157 (15%) Query: 21 YKARDPHSGHFVALKS---VRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDV 77 Y R S +K R + T+ E LL +L + Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIP--------GL 89 Query: 78 CATSRTDREIK-VTLVFEHVDQDL---------RTYLDKAPPPGLPAETIKDLMRQFLRG 127 C + + E + +DL + +L + + +R+ R Sbjct: 90 CVPQLIACDPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYS-DLVATTLRKVGRQ 148 Query: 128 LDFLHANCIVHRDLKPENILVTSGG---TVKLADFGL 161 + LH N H DL NI++ G T L DFGL Sbjct: 149 IGLLHWNDYCHGDLTSSNIVLVRDGARWTPHLIDFGL 185 >3DZO-A nrPDB Length = 413 Score = 42.6 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 33/216 (15%), Positives = 67/216 (31%), Gaps = 35/216 (16%) Query: 22 KARDPHSGHFV--------------ALKSVRVPNGGGGGGGLPISTVREVALLRRL---E 64 +A D +G A+K ++ + + LR + + Sbjct: 96 EATDQETGESFEVHVPYFTERPPSNAIKQMKEEVLRLRLLRGIKNQKQAKVHLRFIFPFD 155 Query: 65 AFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTY-----LDKAPPPGLPAETIKD 119 + P +++ V R + ++ + +L+T+ + L Sbjct: 156 LVKDPQKKKMIRVRLDERDMWVLSRFFLYPRMQSNLQTFGEVLLSHSSTHKSLVHHARLQ 215 Query: 120 LMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLW 179 L Q +R L LH +VH L+P +I++ G V L F + + + Sbjct: 216 LTLQVIRLLASLHHYGLVHTYLRPVDIVLDQRGGVFLTGFE--HLVRDGASAVSPIG-RG 272 Query: 180 YRAPEVLLQSTY----------ATPVDMWSVGCIFA 205 + PE + D W++G Sbjct: 273 FAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIY 308 >2W1Z-A nrPDB Length = 368 Score = 42.6 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 25/142 (17%), Positives = 45/142 (31%), Gaps = 13/142 (9%) Query: 105 DKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARI 164 + L L Q +R L +VH D + NIL+ G V L F + Sbjct: 181 HSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLDQRGGVFLTGFE--HL 238 Query: 165 YSYQMALTPVVVTLWYRAPE-----VLLQSTY-----ATPVDMWSVGCIFAEMFRRKPLF 214 + + + PE +L + P D W++G ++ Sbjct: 239 VRDGASAVSPIG-RGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWCADLPN 297 Query: 215 CGNSEADQLGKIFDLIGLPPED 236 ++E + I+ P+ Sbjct: 298 TEDAELGGIEWIYRRCKNIPQP 319 >5YK0-A nrPDB Length = 452 Score = 41.0 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 27/178 (15%), Positives = 51/178 (28%), Gaps = 47/178 (26%) Query: 18 GTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEA------------ 65 G V+KA G VA+K ++ P + R V +L++L Sbjct: 146 GQVHKAIW-SDGREVAVK-IQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELV 203 Query: 66 -----------------------FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRT 102 +HP ++ E ++ Sbjct: 204 ERTEMELDYRLEAANQRAFAKAYHDHPR-------FQVPHVVASAPKVVIQEWIEGVPMA 256 Query: 103 YLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFG 160 + + + I L+ + D ++H D P N ++ G + + DFG Sbjct: 257 EIIRHGTTE-QRDLIGTLLAELT--FDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFG 311 >6G18-v nrPDB Length = 552 Score = 38.7 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 16/152 (10%), Positives = 48/152 (31%), Gaps = 27/152 (17%) Query: 8 PVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 + +G ++ R+ + + + +S ++E A ++ L + Sbjct: 123 KLHRLGRTSF------RNLKNKRDY----HKHRHNVSWLYLSRLSAMKEFAYMKALYERK 172 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 P + + +V E ++ + P + +L+ + Sbjct: 173 FP----------VPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLA-- 220 Query: 128 LDFLHANCIVHRDLKPENILVTSGGTVKLADF 159 + ++H D N+++ + + DF Sbjct: 221 -----NHGLIHGDFNEFNLILDESDHITMIDF 247 >6FDN-A nrPDB Length = 320 Score = 36.8 bits (84), Expect = 0.010, Method: Composition-based stats. Identities = 16/152 (10%), Positives = 48/152 (31%), Gaps = 27/152 (17%) Query: 8 PVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 + +G ++ R+ + + + +S ++E A ++ L + Sbjct: 123 KLHRLGRTSF------RNLKNKRDY----HKHRHNVSWLYLSRLSAMKEFAYMKALYERK 172 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 P + + +V E ++ + P + +L+ + Sbjct: 173 FP----------VPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLA-- 220 Query: 128 LDFLHANCIVHRDLKPENILVTSGGTVKLADF 159 + ++H D N+++ + + DF Sbjct: 221 -----NHGLIHGDFNEFNLILDESDHITMIDF 247 >6DFL-A nrPDB Length = 259 Score = 35.7 bits (81), Expect = 0.029, Method: Composition-based stats. Identities = 19/105 (18%), Positives = 33/105 (31%), Gaps = 3/105 (2%) Query: 79 ATSRTDREIKVTLVFEHVDQ--DLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCI 136 +V E + DL + P + L+ R + +H + Sbjct: 100 ERGSDPARQHSFIVTEELAPTVDLEVFSQDWRERPPPPRLKRALVEAVARMVGDMHRAGV 159 Query: 137 VHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYR 181 HRD + L+ + V DF L+ + A T +R Sbjct: 160 NHRDCYICHFLLHTDKPVSADDFRLS-VIDLHRAQTRDATPKRWR 203 >1TQM-A nrPDB Length = 282 Score = 34.5 bits (78), Expect = 0.059, Method: Composition-based stats. Identities = 29/165 (17%), Positives = 50/165 (30%), Gaps = 35/165 (21%) Query: 8 PVAEIGVGAYGTVYKARDPHSGHFVA------------LKSVRVPNGGGGGGGLPISTVR 55 +G G V+ G V +K R S Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSFKKVKEKRDYGDLHFSVLAIRSARN 153 Query: 56 EVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD-QDLRTYLDKAPPPGLPA 114 E L++L+ P ++ + ++ E +D ++L + P L Sbjct: 154 EFRALQKLQGLAVP---KVYAWEGNA---------VLMELIDAKELYRVRVENPDEVLDM 201 Query: 115 ETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADF 159 L + + IVH DL N+LV+ G + + DF Sbjct: 202 ---------ILEEVAKFYHRGIVHGDLSQYNVLVSEEG-IWIIDF 236 >6FAI-l nrPDB Length = 425 Score = 33.0 bits (74), Expect = 0.19, Method: Composition-based stats. Identities = 28/178 (15%), Positives = 50/178 (28%), Gaps = 42/178 (23%) Query: 6 YEPVAEIGVGAYGTVYKARDPHSGHFVALKSVR---------------VPNGGGGGGGLP 50 Y IGVG +YK D + V +K R + G + Sbjct: 95 YSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKKSNQGANWMH 153 Query: 51 ISTV---REVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKA 107 +S + +E + L + + +V E ++ L K Sbjct: 154 LSRLAANKEYQFMSMLYSKG----------FKVPEPFDNSRHIVVMELIEGYPMRRLRKH 203 Query: 108 PPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTS------GGTVKLADF 159 I L + + L + ++H D NI++ + DF Sbjct: 204 KN-------IPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >5JY7-I nrPDB Length = 441 Score = 33.0 bits (74), Expect = 0.19, Method: Composition-based stats. Identities = 10/43 (23%), Positives = 16/43 (37%) Query: 57 VALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQD 99 + L R L +P+V RL+ T + +V E Sbjct: 158 IELNRVLARAGNPHVARLLGSFETEWEGEPYALGMVTEFAANS 200 >4ESA-B nrPDB Length = 146 Score = 31.4 bits (70), Expect = 0.51, Method: Composition-based stats. Identities = 13/69 (18%), Positives = 26/69 (37%), Gaps = 3/69 (4%) Query: 15 GAYGTVYKARDPHSGHFVA---LKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNV 71 G++G +Y A VA +K + + E+++L + P+ Sbjct: 43 GSFGNLYNAEAIIGNQKVAAHGIKVLHGLDRAVKNMDNIKEIYAELSILHSEKLHVDPDN 102 Query: 72 VRLMDVCAT 80 +L+ C T Sbjct: 103 FKLLADCLT 111 >5FBM-A nrPDB Length = 99 Score = 31.0 bits (69), Expect = 0.68, Method: Composition-based stats. Identities = 14/46 (30%), Positives = 21/46 (45%), Gaps = 6/46 (13%) Query: 7 EPVAEIGVGAYGTVY-----KARDPHSGHFVALKSVRVPNGGGGGG 47 E V IG G + V K R+P +G + +K+ +VP G Sbjct: 41 EKVQLIGFGNF-EVRERAARKGRNPQTGEEIKIKASKVPAFKAGKA 85 >3TYK-A nrPDB Length = 362 Score = 30.6 bits (68), Expect = 0.91, Method: Composition-based stats. Identities = 10/49 (20%), Positives = 18/49 (36%) Query: 134 NCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRA 182 +VH D N+L +G + D+ A Q + + + A Sbjct: 213 RHLVHADFGSNNVLTDNGRITAVIDWSEAMFGDSQYEVANIFFWRPWLA 261 >4BVU-A nrPDB Length = 211 Score = 29.9 bits (66), Expect = 1.4, Method: Composition-based stats. Identities = 28/155 (18%), Positives = 47/155 (30%), Gaps = 28/155 (18%) Query: 8 PVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL--RRLEA 65 IG G+ +++ V + L + E+ + + E Sbjct: 44 LGKLIGQGSTAEIFE-------------DVNDSSALYKKYDLIGNQYNEILEMAWQESEL 90 Query: 66 FEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFL 125 F A+ V L V + +D A P + I+ L Q + Sbjct: 91 FN-----AFYGDEASVVIQYGGDVYLRMLRVPGTPLSDIDTADIP----DNIESLYLQLI 141 Query: 126 RGLDFLHANCIVHRDLKPENILVTSGGT-VKLADF 159 L+ L I+H DL N+L + DF Sbjct: 142 CKLNEL---SIIHYDLNTGNMLYDKESESLFPIDF 173 >3ZO9-A nrPDB Length = 593 Score = 29.5 bits (65), Expect = 1.7, Method: Composition-based stats. Identities = 30/162 (18%), Positives = 46/162 (28%), Gaps = 50/162 (30%) Query: 158 DFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVD---------------MWSVGC 202 DFG AR ++Y EVL+++ Y + D W +G Sbjct: 22 DFGHARTLPTDTNWFKHA--VFY---EVLVRAFYDSNADGIGDLRGLTEKLDYIKW-LGV 75 Query: 203 -IFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVV 261 P F + D I D + PE D A RG R + Sbjct: 76 DCLW-----LPPFYDSPLRDGGYDIRDFYKVLPEFGTVDDFVTLLDAAHRRGIRIITD-- 128 Query: 262 PEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE 303 L N ++ + H + + NP+ Sbjct: 129 --------------LVMNH----TSDQ---HEWFQESRHNPD 149 >5N28-B nrPDB Length = 444 Score = 29.5 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 10/81 (12%), Positives = 30/81 (37%), Gaps = 1/81 (1%) Query: 70 NVVRLMDVCAT-SRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 N+ L+ ++ +V +V + ++ + +T M + Sbjct: 174 NIASLLGAPTNLEGLGYALRNIMVNHYVATTKKNIMNAVAFASIMEQTAMFEMGDAIGSF 233 Query: 129 DFLHANCIVHRDLKPENILVT 149 + LH + ++ L +N+++ Sbjct: 234 ERLHLLGLAYQGLNADNLVID 254 >4GYG-A nrPDB Length = 397 Score = 29.5 bits (65), Expect = 1.9, Method: Composition-based stats. Identities = 24/162 (14%), Positives = 49/162 (30%), Gaps = 37/162 (22%) Query: 8 PVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFE 67 + +G ++ TV RD +R + G ++ ++E A ++ L Sbjct: 125 KIHRLGRISFRTVKANRD----------YLRNRSTGSWMYLSRLAAIKEFAFMKAL---- 170 Query: 68 HPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRG 127 + + + T+V L L +P L + Sbjct: 171 ------YEEGFPVPEPIAQSRHTIVM-----SLVDALPMRQVSSVPDP--ASLYADLIAL 217 Query: 128 LDFLHANCIVHRDLKPENILVTSGGTVK----------LADF 159 + L + ++H D NIL+ + + DF Sbjct: 218 ILRLAKHGLIHGDFNEFNILIREEKDAEDPSSITLTPIIIDF 259 >1VHE-A nrPDB Length = 373 Score = 29.1 bits (64), Expect = 2.2, Method: Composition-based stats. Identities = 8/21 (38%), Positives = 13/21 (61%), Gaps = 2/21 (9%) Query: 57 VALLRRLEAFEHPNVVRLMDV 77 + +LR L+ +HPN+V V Sbjct: 193 IDVLRNLQNTDHPNIV--YGV 211 >5N1Q-B nrPDB Length = 443 Score = 28.7 bits (63), Expect = 3.1, Method: Composition-based stats. Identities = 9/81 (11%), Positives = 31/81 (38%), Gaps = 1/81 (1%) Query: 70 NVVRLMDVCATSRTDRE-IKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGL 128 N+ L+ + ++ +V +V + ++ + +T M + Sbjct: 174 NIASLLGAPSNMEGLGYALRNIMVNHYVATTKKNLMNAVAFASIMEQTAMFEMGDAIGSF 233 Query: 129 DFLHANCIVHRDLKPENILVT 149 + +H + ++ L +N+++ Sbjct: 234 ERMHLLGLAYQGLNSDNLVID 254 >6EF6-A nrPDB Length = 354 Score = 28.7 bits (63), Expect = 3.3, Method: Composition-based stats. Identities = 10/28 (35%), Positives = 16/28 (57%), Gaps = 3/28 (10%) Query: 135 CIVHRDLKPENILVTSG---GTVKLADF 159 ++H DL+ N+LV S T+ + DF Sbjct: 226 GLIHADLRLANLLVDSSTPQRTITVIDF 253 >6EN4-C nrPDB Length = 852 Score = 28.3 bits (62), Expect = 3.7, Method: Composition-based stats. Identities = 12/76 (15%), Positives = 29/76 (38%), Gaps = 7/76 (9%) Query: 200 VGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQS 259 +G + E + S L I ++IG+ ++ P PR +++ Sbjct: 522 LGVVLYEYLGEEYPEVLGSILGALKAIVNVIGM-------HKMTPPIKDLLPRLTPILKN 574 Query: 260 VVPEMEESGAQLLLEM 275 +++E+ L+ + Sbjct: 575 RHEKVQENCIDLVGRI 590 >1OXZ-A nrPDB Length = 186 Score = 27.9 bits (61), Expect = 4.8, Method: Composition-based stats. Identities = 14/61 (22%), Positives = 25/61 (40%), Gaps = 1/61 (1%) Query: 224 GKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKR 283 K+ D P P++V R ++S PE + +L+ EM+ + KR Sbjct: 9 PKLPDDTTFPLPPPRPKNVIFEDEEKSKMLARLLKSSHPEDLRAANKLIKEMVQED-QKR 67 Query: 284 I 284 + Sbjct: 68 M 68 >3QLB-A nrPDB Length = 748 Score = 27.9 bits (61), Expect = 5.0, Method: Composition-based stats. Identities = 15/32 (46%), Positives = 18/32 (56%) Query: 152 GTVKLADFGLARIYSYQMALTPVVVTLWYRAP 183 G V LAD GLA SY + PV+ T +Y P Sbjct: 512 GLVYLADNGLAPYISYSTSFDPVLGTNFYGTP 543 >1R5O-A nrPDB Length = 467 Score = 27.9 bits (61), Expect = 6.0, Method: Composition-based stats. Identities = 10/74 (13%), Positives = 22/74 (29%), Gaps = 3/74 (4%) Query: 52 STVREV--ALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPP 109 EV LL+ + EH N+V + ++ + + VD+ +++ Sbjct: 25 DLQNEVDQELLKDMYGKEHVNIV-FIGHVDAGKSTLGGNILFLTGMVDKRTMEKIEREAK 83 Query: 110 PGLPAETIKDLMRQ 123 Sbjct: 84 EAGKESWYLSWALD 97 >4R7B-A nrPDB Length = 309 Score = 27.6 bits (60), Expect = 6.5, Method: Composition-based stats. Identities = 14/68 (20%), Positives = 27/68 (39%), Gaps = 1/68 (1%) Query: 101 RTYLDKAPPPGLPAETIKDLMRQFLRGLDFLH-ANCIVHRDLKPENILVTSGGTVKLADF 159 L + P E++++ + + L L H DL PEN + + G + L D+ Sbjct: 156 YESLIEEQIPYANYESVRNAVFSLEKRLADLGVDRKSCHIDLVPENFIESPQGRLYLIDW 215 Query: 160 GLARIYSY 167 + + Sbjct: 216 EYSSMNDP 223 >4D0L-A nrPDB Length = 566 Score = 27.6 bits (60), Expect = 6.9, Method: Composition-based stats. Identities = 23/180 (12%), Positives = 50/180 (27%), Gaps = 22/180 (12%) Query: 99 DLRTYLDKAPPPGLPAE--TIKDLMRQFLRG---LDFLHANCIVHRDLKPENILVTSGGT 153 L Y + + + Q G + +L H NIL+ + G Sbjct: 396 SLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHN----GNILLDAEGH 451 Query: 154 VKLADFGL---ARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRR 210 + DFG + + + +T + DM++ +M Sbjct: 452 IIHIDFGFILSSSPRNLGFETSAFKLTTEFV------DVMGGLDGDMFNY----YKMLML 501 Query: 211 KPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQ 270 + L D++ +I +++ + S R + + + E Sbjct: 502 QGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVD 561 >6GL3-A nrPDB Length = 386 Score = 27.6 bits (60), Expect = 7.2, Method: Composition-based stats. Identities = 23/180 (12%), Positives = 50/180 (27%), Gaps = 22/180 (12%) Query: 99 DLRTYLDKAPPPGLPAE--TIKDLMRQFLRG---LDFLHANCIVHRDLKPENILVTSGGT 153 L Y + + + Q G + +L H NIL+ + G Sbjct: 217 SLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHN----GNILLDAEGH 272 Query: 154 VKLADFGL---ARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRR 210 + DFG + + + +T + DM++ +M Sbjct: 273 IIHIDFGFILSSSPRNLGFETSAFKLTTEFV------DVMGGLDGDMFNY----YKMLML 322 Query: 211 KPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQ 270 + L D++ +I +++ + S R + + + E Sbjct: 323 QGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVD 382 >5C4G-E nrPDB Length = 529 Score = 27.2 bits (59), Expect = 9.1, Method: Composition-based stats. Identities = 23/180 (12%), Positives = 50/180 (27%), Gaps = 22/180 (12%) Query: 99 DLRTYLDKAPPPGLPAE--TIKDLMRQFLRG---LDFLHANCIVHRDLKPENILVTSGGT 153 L Y + + + Q G + +L H NIL+ + G Sbjct: 359 SLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHN----GNILLDAEGH 414 Query: 154 VKLADFGL---ARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRR 210 + DFG + + + +T + DM++ +M Sbjct: 415 IIHIDFGFILSSSPRNLGFETSAFKLTTEFV------DVMGGLDGDMFNY----YKMLML 464 Query: 211 KPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQ 270 + L D++ +I +++ + S R + + + E Sbjct: 465 QGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVD 524 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.313 0.149 0.474 Lambda K H 0.267 0.0453 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,859,071 Number of Sequences: 36641 Number of extensions: 586798 Number of successful extensions: 5834 Number of sequences better than 10.0: 524 Number of HSP's better than 10.0 without gapping: 952 Number of HSP's successfully gapped in prelim test: 51 Number of HSP's that attempted gapping in prelim test: 1843 Number of HSP's gapped (non-prelim): 1191 length of query: 303 length of database: 10,336,785 effective HSP length: 97 effective length of query: 206 effective length of database: 6,782,608 effective search space: 1397217248 effective search space used: 1397217248 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 59 (27.2 bits)