BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P11712 (490 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5W0C-A nrPDB 967 0.0 4GQS-A nrPDB 883 0.0 2NNH-A nrPDB 771 0.0 1N6B-A nrPDB 753 0.0 3E6I-A nrPDB 590 e-169 4H1N-A nrPDB 512 e-145 5E0E-A nrPDB 494 e-140 2PG7-A nrPDB 489 e-138 5E58-A nrPDB 486 e-138 3IBD-A nrPDB 475 e-134 3TBG-A nrPDB 325 4e-89 3DL9-A nrPDB 283 1e-76 4R20-A nrPDB 244 6e-65 6DWN-A nrPDB 237 1e-62 6B82-A nrPDB 234 8e-62 6IQ5-A nrPDB 233 2e-61 4R1Z-A nrPDB 216 1e-56 2HI4-A nrPDB 214 5e-56 5UYS-A nrPDB 196 3e-50 5VBU-A nrPDB 184 5e-47 3QZ1-A nrPDB 175 3e-44 5YLW-A nrPDB 156 2e-38 6DA2-A nrPDB 127 1e-29 5VEU-A nrPDB 126 2e-29 3K9V-A nrPDB 97 2e-20 3MDV-A nrPDB 86 4e-17 2VE3-A nrPDB 86 4e-17 6AYB-A nrPDB 83 3e-16 3S79-A nrPDB 73 2e-13 3EL3-A nrPDB 72 7e-13 3N9Z-A nrPDB 71 9e-13 6C94-A nrPDB 70 3e-12 3MZS-A nrPDB 69 5e-12 4ZGX-A nrPDB 67 1e-11 2WX2-A nrPDB 67 1e-11 5FOI-A nrPDB 66 4e-11 5FSA-A nrPDB 65 8e-11 4KPA-A nrPDB 63 3e-10 5JLC-A nrPDB 63 4e-10 6M7X-A nrPDB 62 8e-10 4WMZ-A nrPDB 61 1e-09 3L4D-A nrPDB 60 2e-09 2ZBZ-A nrPDB 60 3e-09 2X2N-A nrPDB 59 4e-09 3TYW-A nrPDB 58 9e-09 6B11-A nrPDB 57 1e-08 4OQR-A nrPDB 57 1e-08 4OQS-A nrPDB 57 2e-08 3EJB-B nrPDB 56 3e-08 6CR2-A nrPDB 56 3e-08 2W0A-A nrPDB 56 3e-08 5VWS-A nrPDB 56 3e-08 2Y5N-A nrPDB 56 4e-08 6FSH-A nrPDB 55 9e-08 2VZM-A nrPDB 55 1e-07 4TX3-A nrPDB 54 1e-07 3JUS-A nrPDB 54 1e-07 6GMF-A nrPDB 54 2e-07 3A1L-A nrPDB 54 2e-07 5EX6-C nrPDB 54 2e-07 1WIY-A nrPDB 53 3e-07 1Z8P-A nrPDB 53 3e-07 1CPT-A nrPDB 52 5e-07 6M7L-A nrPDB 52 5e-07 5LIV-A nrPDB 52 8e-07 5CJE-A nrPDB 52 9e-07 5Y1I-A nrPDB 51 1e-06 6F88-A nrPDB 50 1e-06 3TKT-A nrPDB 50 2e-06 3ABB-A nrPDB 50 2e-06 3SN5-A nrPDB 50 2e-06 5L1U-A nrPDB 49 7e-06 2Z36-A nrPDB 48 1e-05 4GGV-A nrPDB 47 1e-05 6GK6-A nrPDB 47 2e-05 2IJ7-A nrPDB 47 2e-05 4WPZ-A nrPDB 47 2e-05 6A7I-A nrPDB 47 2e-05 4RM4-A nrPDB 47 3e-05 2RFC-A nrPDB 47 3e-05 1Q5D-A nrPDB 46 3e-05 5YSW-A nrPDB 46 3e-05 3P3Z-A nrPDB 46 4e-05 4UBS-A nrPDB 46 4e-05 1LG9-A nrPDB 45 5e-05 5YHJ-A nrPDB 45 7e-05 4MM0-A nrPDB 45 9e-05 6A7J-A nrPDB 44 1e-04 3MGX-A nrPDB 44 2e-04 5HH3-A nrPDB 43 4e-04 6F0B-A nrPDB 43 4e-04 3R9C-A nrPDB 42 7e-04 5M0P-A nrPDB 42 8e-04 4YZR-A nrPDB 42 8e-04 2IAG-A nrPDB 42 9e-04 6FYJ-A nrPDB 42 9e-04 5EX8-A nrPDB 41 0.001 3WVS-A nrPDB 40 0.002 5IT1-A nrPDB 40 0.002 1ODO-A nrPDB 40 0.002 5XW2-A nrPDB 40 0.002 5HIW-A nrPDB 40 0.003 5OFQ-A nrPDB 39 0.004 4YT3-A nrPDB 39 0.004 3A50-A nrPDB 39 0.006 6GII-A nrPDB 39 0.007 3AWQ-A nrPDB 38 0.008 3OO3-A nrPDB 38 0.010 3IVY-A nrPDB 38 0.010 5HDI-A nrPDB 38 0.010 1GWI-A nrPDB 38 0.010 5Z9I-A nrPDB 38 0.011 2X9P-A nrPDB 38 0.012 2XKR-A nrPDB 38 0.012 3RWL-A nrPDB 37 0.015 4JBT-A nrPDB 37 0.016 5GWE-A nrPDB 36 0.030 5LIE-A nrPDB 36 0.033 2ZQJ-A nrPDB 36 0.033 5XNT-A nrPDB 36 0.033 5XJN-A nrPDB 36 0.037 4XE3-A nrPDB 35 0.053 6G71-A nrPDB 35 0.055 3ABA-A nrPDB 35 0.100 5L94-A nrPDB 34 0.11 2WM5-A nrPDB 34 0.14 4TRI-A nrPDB 34 0.19 6CVC-A nrPDB 33 0.30 4Z5P-A nrPDB 33 0.31 3B98-A nrPDB 32 0.47 2QBO-A nrPDB 32 0.48 1EHE-A nrPDB 32 0.92 5OMS-A nrPDB 31 1.1 3WEC-A nrPDB 30 2.1 1PIO-A nrPDB 30 3.5 4CQI-A nrPDB 29 5.5 4DJD-D nrPDB 29 5.6 3Q5X-A nrPDB 28 9.2 >5W0C-A nrPDB Length = 477 Score = 967 bits (2501), Expect = 0.0, Method: Compositional matrix adjust. Identities = 467/470 (99%), Positives = 469/470 (99%) Query: 21 RQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGY 80 + SSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGY Sbjct: 4 KTSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGY 63 Query: 81 EAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRS 140 EAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRS Sbjct: 64 EAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRS 123 Query: 141 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEK 200 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEK Sbjct: 124 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEK 183 Query: 201 LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNP 260 LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNP Sbjct: 184 LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNP 243 Query: 261 QDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVT 320 QDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVT Sbjct: 244 QDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVT 303 Query: 321 AKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYL 380 AKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYL Sbjct: 304 AKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYL 363 Query: 381 IPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEAL 440 IPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEAL Sbjct: 364 IPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEAL 423 Query: 441 AGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV 490 AGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIP+ Sbjct: 424 AGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPI 473 >4GQS-A nrPDB Length = 477 Score = 883 bits (2281), Expect = 0.0, Method: Compositional matrix adjust. Identities = 427/470 (90%), Positives = 448/470 (95%) Query: 21 RQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGY 80 + SSGRGKLPPGPTPLPVIGNILQI IKD+SKSLTNLSK+YGPVFTLYFGL+ +VVLHGY Sbjct: 4 KTSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGY 63 Query: 81 EAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRS 140 E VKEALIDLGEEFSGRG FPLAERANRGFGIVFSNGK+WKEIRRFSLMTLRNFGMGKRS Sbjct: 64 EVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRS 123 Query: 141 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEK 200 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF KRFDYKDQQFLNLMEK Sbjct: 124 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEK 183 Query: 201 LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNP 260 LNENI+I+S+PWIQICNNF IIDYFPGTHNKLLKN+AFM+S ILEKVKEHQESMD+NNP Sbjct: 184 LNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNP 243 Query: 261 QDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVT 320 +DFIDCFL+KMEKEK NQ SEFTIE+L TA DL GAGTETTSTTLRYALLLLLKHPEVT Sbjct: 244 RDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVT 303 Query: 321 AKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYL 380 AKVQEEIERV+GRNRSPCMQDR HMPYTDAVVHEVQRYIDL+PTSLPHAVTCD+KFRNYL Sbjct: 304 AKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYL 363 Query: 381 IPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEAL 440 IPKGTTIL SLTSVLHDNKEFPNPEMFDP HFLDEGGNFKKS YFMPFSAGKRICVGE L Sbjct: 364 IPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGL 423 Query: 441 AGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV 490 A MELFLFLT ILQNFNLKSL+DPK+LDTTPVVNGFASVPPFYQLCFIP+ Sbjct: 424 ARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPI 473 >2NNH-A nrPDB Length = 476 Score = 771 bits (1991), Expect = 0.0, Method: Compositional matrix adjust. Identities = 366/472 (77%), Positives = 412/472 (87%) Query: 19 LWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH 78 + +++S +GKLPPGPTPLP+IGN+LQI +KDI KS TN SKVYGPVFT+YFG+ PIVV H Sbjct: 1 MAKKTSSKGKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFH 60 Query: 79 GYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK 138 GYEAVKEALID GEEFSGRG P+++R +G GI+ SNGK+WKEIRRFSL TLRNFGMGK Sbjct: 61 GYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGK 120 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLM 198 RSIEDRVQEEA CLVEELRKTKASPCDPTFILGCAPCNVICS++F KRFDYKDQ FL LM Sbjct: 121 RSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLM 180 Query: 199 EKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMN 258 ++ NEN +IL+SPWIQ+CNNF +ID FPGTHNK+LKNVA +SYI EKVKEHQ S+D+N Sbjct: 181 KRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVN 240 Query: 259 NPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPE 318 NP+DFIDCFL+KME+EK NQ SEF IE+L T DLF AGTETTSTTLRY LLLLLKHPE Sbjct: 241 NPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPE 300 Query: 319 VTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRN 378 VTAKVQEEI+ VIGR+RSPCMQDRSHMPYTDAVVHE+QRY DL+PT +PHAVT D KFRN Sbjct: 301 VTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRN 360 Query: 379 YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGE 438 YLIPKGTTI+ LTSVLHD+KEFPNP +FDP HFLD+ GNFKKS YFMPFSAGKRIC GE Sbjct: 361 YLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGE 420 Query: 439 ALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV 490 LA MELFLFLT+ILQNFNLKS+ D KNL+TT V G S+PP YQ+CFIPV Sbjct: 421 GLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV 472 >1N6B-A nrPDB Length = 473 Score = 753 bits (1943), Expect = 0.0, Method: Compositional matrix adjust. Identities = 353/472 (74%), Positives = 412/472 (87%), Gaps = 3/472 (0%) Query: 19 LWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH 78 + +++S +GKLPPGPTP P+IGNILQI KDISKSLT S+ YGPVFT+Y G+KP VVLH Sbjct: 1 MAKKTSSKGKLPPGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLH 60 Query: 79 GYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK 138 GYEAVKEAL+DLGEEF+GRG P+ E+ ++G GI FSN K WKE+RRFSLMTLRNFGMGK Sbjct: 61 GYEAVKEALVDLGEEFAGRGSVPILEKVSKGLGIAFSNAKTWKEMRRFSLMTLRNFGMGK 120 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLM 198 RSIEDR+QEEARCLVEELRKT ASPCDPTFILGCAPCNVICS+IFH RFDYKD++FL LM Sbjct: 121 RSIEDRIQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKLM 180 Query: 199 EKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMN 258 E L+EN+++L +PW+Q+ NNF ++DYFPG H LLKN ++K++I+EKVKEHQ+ +D+N Sbjct: 181 ESLHENVELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLLDVN 240 Query: 259 NPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPE 318 NP+DFIDCFL+KME+E + EFT+ESL DLFGAGTETTSTTLRY+LLLLLKHPE Sbjct: 241 NPRDFIDCFLIKMEQENN---LEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPE 297 Query: 319 VTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRN 378 V A+VQEEIERVIGR+RSPCMQDRS MPYTDAV+HE+QR+IDLLPT+LPHAVT D++FRN Sbjct: 298 VAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFRN 357 Query: 379 YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGE 438 Y IPKGT I+ SLTSVLHD K FPNP++FDP HFLDE GNFKKS YFMPFSAGKR+CVGE Sbjct: 358 YFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRMCVGE 417 Query: 439 ALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV 490 LA MELFLFLTSILQNF L+SLV+PK+LD T VVNGF SVPP YQLCFIP+ Sbjct: 418 GLARMELFLFLTSILQNFKLQSLVEPKDLDITAVVNGFVSVPPSYQLCFIPI 469 >3E6I-A nrPDB Length = 476 Score = 590 bits (1521), Expect = e-169, Method: Compositional matrix adjust. Identities = 274/471 (58%), Positives = 358/471 (76%), Gaps = 1/471 (0%) Query: 19 LWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH 78 + +++S +GKLPPGP PLP+IGN+ Q+ +K+I KS T L++ +GPVFTLY G + +VV+H Sbjct: 1 MAKKTSSKGKLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 60 Query: 79 GYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK 138 GY+AVKEAL+D +EFSGRG P A A+R GI+F+NG WK+IRRFSL TLRN+GMGK Sbjct: 61 GYKAVKEALLDYKDEFSGRGDLP-AFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGK 119 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLM 198 + E R+Q EA L+E LRKT+ P DPTF++GCAPCNVI I+F K FDY D++FL LM Sbjct: 120 QGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLM 179 Query: 199 EKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMN 258 NEN +LS+PW+Q+ NNF + Y PG+H K++KNVA +K Y+ E+VKEH +S+D N Sbjct: 180 YLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 239 Query: 259 NPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPE 318 P+D DC L++MEKEKH+ +T++ + T DLF AGTETTSTTLRY LL+L+K+PE Sbjct: 240 CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPE 299 Query: 319 VTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRN 378 + K+ EEI+RVIG +R P ++DR MPY DAVVHE+QR+I L+P++LPH T D FR Sbjct: 300 IEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRG 359 Query: 379 YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGE 438 YLIPKGT ++ +L SVL+DN+EFP+PE F P HFL+E G FK S YF PFS GKR+C GE Sbjct: 360 YLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGE 419 Query: 439 ALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIP 489 LA MELFL L +ILQ+FNLK LVDPK++D +P+ GF +PP Y+LC IP Sbjct: 420 GLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIP 470 >4H1N-A nrPDB Length = 479 Score = 512 bits (1319), Expect = e-145, Method: Compositional matrix adjust. Identities = 239/470 (50%), Positives = 343/470 (72%) Query: 19 LWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH 78 + +++S +GKLPPGP+PLPV+GN+LQ+ K + +S L + YG VFT+Y G +P+VVL Sbjct: 1 MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLC 60 Query: 79 GYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK 138 G +A++EAL+D E FSGRG + + +G+G++F+NG++W+ +RRFSL T+R+FGMGK Sbjct: 61 GTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRFSLATMRDFGMGK 120 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLM 198 RS+E+R+QEEARCLVEELRK+K + D T + N+ICSI+F KRFDYKD FL L+ Sbjct: 121 RSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRLL 180 Query: 199 EKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMN 258 + ++ ++SS Q+ FS + YFPGTH ++ +N+ + ++I + V++H+ ++D + Sbjct: 181 DLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPS 240 Query: 259 NPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPE 318 NP+DFID +L++MEK+K + SEF ++L T + LF AGTETTSTTLRY LL+LK+P Sbjct: 241 NPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLKYPH 300 Query: 319 VTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRN 378 VT +VQ+EIE+VIG +R P + DR+ MPYTDAV+HE+QR DL+P +PH VT D +FR Sbjct: 301 VTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRG 360 Query: 379 YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGE 438 Y+IPK T + L+S LHD + F P F+P HFLD G K+++ FMPFS GKRIC+GE Sbjct: 361 YVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRICLGE 420 Query: 439 ALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFI 488 +A ELFLF T+ILQNF++ S V P+++D TP +G +VPP YQ+ F+ Sbjct: 421 GIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNVPPSYQIRFL 470 >5E0E-A nrPDB Length = 463 Score = 494 bits (1273), Expect = e-140, Method: Compositional matrix adjust. Identities = 230/448 (51%), Positives = 326/448 (72%) Query: 41 NILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIF 100 N+LQ+ S + + YG VFT++ G +P+V+L+G EA++EAL+D E FSGRG Sbjct: 14 NLLQMDRGGFLNSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI 73 Query: 101 PLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK 160 + E RG+G+VF+NG++WK +RRFSL+T+R+FGMGKRS+E+R+QEEARCLVEE RK++ Sbjct: 74 AVVEPIFRGYGVVFANGERWKALRRFSLVTMRDFGMGKRSVEERIQEEARCLVEEFRKSQ 133 Query: 161 ASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFS 220 +P DPTF+ C N+ICSI+F +RFDYKD QFL L+ ++ ++SS Q+ FS Sbjct: 134 GAPLDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFS 193 Query: 221 PIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPS 280 + YFPGTH ++ +N+ + YI + V++H+ ++D ++P+DFID +L++MEKEK NQ + Sbjct: 194 GFLKYFPGTHRQISRNLQEILDYIGQSVEKHRATLDPSHPRDFIDTYLLRMEKEKSNQHT 253 Query: 281 EFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQ 340 EF ++L + + LF AGTET+STTLRY LL+LK+P V KVQ+EI++VIG +R P ++ Sbjct: 254 EFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLE 313 Query: 341 DRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKE 400 DR+ MPYT+AV++E+QR+ DL+P +PH VT D FR YL+PK T + L+S LHD + Sbjct: 314 DRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQY 373 Query: 401 FPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKS 460 F P+ F+P HFLD G KKS+ FMPFS GKRIC+GE +A ELFLF T+ILQNF+L S Sbjct: 374 FEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSLSS 433 Query: 461 LVDPKNLDTTPVVNGFASVPPFYQLCFI 488 V PK++D +P +GF VP YQ+CF+ Sbjct: 434 PVAPKDIDLSPKESGFGKVPQTYQICFL 461 >2PG7-A nrPDB Length = 476 Score = 489 bits (1258), Expect = e-138, Method: Compositional matrix adjust. Identities = 233/471 (49%), Positives = 331/471 (70%) Query: 19 LWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH 78 + +++S +GKLPPGPTPLP IGN LQ+ + + SL +S+ YGPVFT++ G + +VVL Sbjct: 1 MAKKTSSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLC 60 Query: 79 GYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK 138 G++AV+EAL+D EEFSGRG + +G+G+VFSNG++ K++RRFS+ TLR+FG+GK Sbjct: 61 GHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGK 120 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLM 198 R IE+R+QEEA L++ LR T + DPTF L NVI SI+F RFDYKD++FL+L+ Sbjct: 121 RGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLL 180 Query: 199 EKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMN 258 + + S+ Q+ FS ++ + PG + + + ++ +I +KV+ +Q ++D N Sbjct: 181 RMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPN 240 Query: 259 NPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPE 318 +P+DFID FL++M++E+ N +EF +++L T + LF GTET STTLRY LLL+KHPE Sbjct: 241 SPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMKHPE 300 Query: 319 VTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRN 378 V AKV EEI+RVIG+NR P +DR+ MPY +AV+HE+QR+ D++P SL V D KFR+ Sbjct: 301 VEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRD 360 Query: 379 YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGE 438 + +PKGT + L SVL D F NP+ F+P HFL+E G FKKS F+PFS GKR C GE Sbjct: 361 FFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGE 420 Query: 439 ALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIP 489 LA MELFLF T+++QNF LKS PK++D +P GFA++P Y + F+P Sbjct: 421 GLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLP 471 >5E58-A nrPDB Length = 493 Score = 486 bits (1251), Expect = e-138, Method: Compositional matrix adjust. Identities = 225/448 (50%), Positives = 318/448 (70%) Query: 41 NILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIF 100 N+LQ+ S + + YG VFT++ G +P+V+L+G EA++EAL+D E FSGRG Sbjct: 42 NLLQMDRGGFLNSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI 101 Query: 101 PLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK 160 + + +G++FSNG++WK +RRFSL T+R+FGMGKRS+EDR+QEEA+CLVEEL+K++ Sbjct: 102 AVIKPVIGDYGMIFSNGERWKVLRRFSLATMRDFGMGKRSVEDRIQEEAQCLVEELQKSQ 161 Query: 161 ASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFS 220 +P DPTF+ C N+ICSI+F +R+DYKD+QFL L++ ++SS Q+ FS Sbjct: 162 GAPLDPTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFS 221 Query: 221 PIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPS 280 + YFPG H ++ +N+ + Y+ + V++H+ ++D +NP+DFID +L++MEKEK NQ + Sbjct: 222 GFMKYFPGAHRQITRNLQEILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEKSNQHT 281 Query: 281 EFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQ 340 EF ++L + + LF AGTETTSTTLRY LL+LK+P V KVQ+EI++VIG +R P ++ Sbjct: 282 EFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLE 341 Query: 341 DRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKE 400 DR+ MPYTDAV+HE+QR+ DL P PH VT D FR YL+PK T + L+S LHD + Sbjct: 342 DRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQY 401 Query: 401 FPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKS 460 F P F+P HFLD G KKS+ FMPFS GKRIC+GE +A ELFLF T+ILQNF++ S Sbjct: 402 FEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSVSS 461 Query: 461 LVDPKNLDTTPVVNGFASVPPFYQLCFI 488 V PK++D +P +G VP YQ+ F+ Sbjct: 462 SVAPKDIDLSPKESGIGKVPQTYQISFL 489 >3IBD-A nrPDB Length = 476 Score = 475 bits (1222), Expect = e-134, Method: Compositional matrix adjust. Identities = 230/471 (48%), Positives = 334/471 (70%) Query: 19 LWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH 78 + +++S +GKLPPGP PLP++GN+LQ+ + + KS + YG VFT++ G +P+V+L Sbjct: 1 MAKKTSSKGKLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC 60 Query: 79 GYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK 138 G EA++EAL+D E FSGRG + + RG+G++F+NG +WK +RRFS+ T+R+FGMGK Sbjct: 61 GVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK 120 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLM 198 RS+E+R+QEEA+CL+EELRK+K + DPTF+ N+ICSI+F KRF Y+DQ+FL ++ Sbjct: 121 RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML 180 Query: 199 EKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMN 258 + ++SS + Q+ FS + +FPG H ++ KN+ + +YI V++H+E++D + Sbjct: 181 NLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPS 240 Query: 259 NPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPE 318 P+D ID +L+ MEKEK N SEF+ ++L + LF AGTETTSTTLRY LL+LK+P Sbjct: 241 APRDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPH 300 Query: 319 VTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRN 378 V +V EIE+VIG +R P + DR+ MPYT+AV++E+QR+ DLLP +PH VT FR Sbjct: 301 VAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRG 360 Query: 379 YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGE 438 Y+IPK T + + L++ LHD F P+ F+P HFLD G KK++ F+PFS GKRIC+GE Sbjct: 361 YIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGE 420 Query: 439 ALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIP 489 +A ELFLF T+ILQNF++ S V P+++D TP G +PP YQ+ F+P Sbjct: 421 GIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLP 471 >3TBG-A nrPDB Length = 479 Score = 325 bits (832), Expect = 4e-89, Method: Compositional matrix adjust. Identities = 196/477 (41%), Positives = 286/477 (59%), Gaps = 13/477 (2%) Query: 21 RQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGY 80 +++S +GKLPPGP PLP +GN+L + ++ L + +G VF+L P+VVL+G Sbjct: 3 KKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGL 62 Query: 81 EAVKEALIDLGEEFSGRGIFPLAE---RANRGFGIVFSN-GKKWKEIRRFSLMTLRNFGM 136 AV+EAL+ GE+ + R P+ + R G+ + G W+E RRFS+ TLRN G+ Sbjct: 63 AAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGL 122 Query: 137 GKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLN 196 GK+S+E V EEA CL P P +L A NVI S+ +RF+Y D +FL Sbjct: 123 GKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLR 182 Query: 197 LMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYIL---EKVKEHQE 253 L++ E +K S +++ N P++ + P K+L+ F K+++ E + EH+ Sbjct: 183 LLDLAQEGLK-EESGFLREVLNAVPVLLHIPALAGKVLR---FQKAFLTQLDELLTEHRM 238 Query: 254 SMD-MNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLL 312 + D P+D + FL +MEK K N S F E+L DLF AG TTSTTL + LLL Sbjct: 239 TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLL 298 Query: 313 LLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTC 372 ++ HP+V +VQ+EI+ VIG+ R P M D++HMPYT AV+HEVQR+ D++P + H + Sbjct: 299 MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSR 358 Query: 373 DIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGK 432 DI+ + + IPKGTT++ +L+SVL D + P F P HFLD G+F K + F+PFSAG+ Sbjct: 359 DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGR 418 Query: 433 RICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIP 489 R C+GE LA MELFLF TS+LQ+F+ S+ + + V F P Y+LC +P Sbjct: 419 RACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFLVSPSPYELCAVP 474 >3DL9-A nrPDB Length = 479 Score = 283 bits (724), Expect = 1e-76, Method: Compositional matrix adjust. Identities = 150/403 (37%), Positives = 242/403 (60%), Gaps = 3/403 (0%) Query: 58 SKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSN- 116 S+VYG +F+L G VVL+GY+ VKE L+ E F+ R PL + + G++ S Sbjct: 44 SQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRY 103 Query: 117 GKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCN 176 G+ W + RR ++ + R FG G++S E ++ EE + + + K P D ++ A N Sbjct: 104 GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSN 163 Query: 177 VICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFP-GTHNKLLK 235 + IIF +RF Y+D F +++E +EN+++ +S + + N F P I P G H +L + Sbjct: 164 ITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAF-PWIGILPFGKHQQLFR 222 Query: 236 NVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLF 295 N A + ++ +++ + PQ F+D +L +M++ K++ S F+ E+L + +L Sbjct: 223 NAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELI 282 Query: 296 GAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEV 355 AGTETT+ LR+A+L + +P + +VQ+EI+ ++G N P D+ MPYT+AV+HEV Sbjct: 283 IAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEV 342 Query: 356 QRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDE 415 R+ +++P + HA + D R Y IPKGTT++ +L SV D K + +PE+F P FLD Sbjct: 343 LRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDS 402 Query: 416 GGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458 G F K + +PFS G+R C+GE LA ME+FLF T++LQ F+L Sbjct: 403 SGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 445 >4R20-A nrPDB Length = 486 Score = 244 bits (623), Expect = 6e-65, Method: Compositional matrix adjust. Identities = 138/413 (33%), Positives = 218/413 (52%), Gaps = 21/413 (5%) Query: 55 TNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGF-GIV 113 T LS YGP+F LY G +V+ V+E L+ G EF+GR + +G I Sbjct: 46 TQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQGGKDIA 105 Query: 114 FSN-GKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC 172 F++ WK RR + FG G ++ VQE A L EEL+ + D + +L Sbjct: 106 FADYSPLWKNHRRLVHSSFTLFGEGSNKLQTIVQEAADSLCEELQACRGQSSDLSVVLMR 165 Query: 173 APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSS-------PWIQICNNFSPIIDY 225 A NVIC ++F + D + +++ + ++ ++ PW++I Sbjct: 166 AVTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQTIARGGLVDIFPWLRI---------- 215 Query: 226 FPGTHNKLLKNVAFMKSYIL-EKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTI 284 FP K LK ++ +L +K+ EH++S+ P+D +D L+ ++ + T Sbjct: 216 FPNKDLKRLKECVSIRDQLLYKKLLEHKKSLTPGEPRDLLDALLIGQQRGSGGA-DDITE 274 Query: 285 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSH 344 + + TA + FGAG ETTSTTL + + LL HP++ +VQ E++ +G +R PC+ DR H Sbjct: 275 DHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSDRPH 334 Query: 345 MPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNP 404 +P DAV+ EV R + P +PH D + +PKGT +L+++ ++ HD K + P Sbjct: 335 LPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWDQP 394 Query: 405 EMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFN 457 E F+P FL+ G K F+PF AG R+CVGE+LA +ELFLF++ LQ F+ Sbjct: 395 EQFNPERFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFS 447 >6DWN-A nrPDB Length = 491 Score = 237 bits (604), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 148/469 (31%), Positives = 254/469 (54%), Gaps = 22/469 (4%) Query: 21 RQSSGRG-KLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHG 79 +++S +G K PPGP P+IG++L +G K+ +L+ +S+ YG V + G P+VVL G Sbjct: 3 KKTSSKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVLSG 61 Query: 80 YEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFS--NGKKWKEIRRFSLMTLRNFGMG 137 + +++AL+ G++F GR + G + FS +G W RR + L++F + Sbjct: 62 LDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 121 Query: 138 KRS-------IEDRVQEEARCLVEELRKTKASPC--DPTFILGCAPCNVICSIIFHKRFD 188 +E+ V +EA L+ L++ A P +P + + NVIC+I F +R+D Sbjct: 122 SDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYD 181 Query: 189 YKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNV-AFMKSYILEK 247 + Q+ L+L+ N +++ S +F PI+ Y P K++ S++ + Sbjct: 182 HNHQELLSLVNLNNNFGEVVGS---GNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKM 238 Query: 248 VKEHQESMDMNNPQDFIDCFLMKMEKEK--HNQPSEFTIESLENTAVDLFGAGTETTSTT 305 VKEH ++ + + +D D + ++++ N + + E + N +DLFGAG +T +T Sbjct: 239 VKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTA 298 Query: 306 LRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTS 365 + ++L+ L+ +P V K+QEE++ VIGR+R P + DRSH+PY +A + E R+ +P + Sbjct: 299 ISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFT 358 Query: 366 LPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKK--SK 423 +PH+ T D + + IPKG + ++ + HD K + NP F P FL G K S+ Sbjct: 359 IPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSE 418 Query: 424 YFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPV 472 + F GKR C+GE +A E+FLFL +LQ + K +D TP+ Sbjct: 419 KVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVK-VDMTPI 466 >6B82-A nrPDB Length = 509 Score = 234 bits (596), Expect = 8e-62, Method: Compositional matrix adjust. Identities = 146/451 (32%), Positives = 239/451 (52%), Gaps = 35/451 (7%) Query: 30 PPGPTPLPVIGNILQIGIKDISKS-----LTNLSKVYGPVFTLYFGLKPIVVLHGYEAVK 84 PP LP+IG+++ + +S S +L K YG +++L G +++++ + K Sbjct: 25 PPSLPSLPIIGSLMSL----VSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNNHHHAK 80 Query: 85 EALIDLGEEFSGRGIFPLAERANR-GFGIVFSN-GKKWKEIRRFSLMTLRNFGMGKRSIE 142 E LI G+ F+GR + R G I F++ WK R+ L FG G SIE Sbjct: 81 EILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKMVHGALCMFGEGSVSIE 140 Query: 143 DRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLN 202 + EA + E L +++ S D L A NV+C++ F+ + D +F ++++ Sbjct: 141 KIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSSYKRGDAEFESMLQYSQ 200 Query: 203 ENIKILSS-------PWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEK-VKEHQES 254 + ++ PW+QI FP ++L+ ++ +L+K +EH+ + Sbjct: 201 GIVDTVAKDSLVDIFPWLQI----------FPNKDLRILRQCISIRDKLLQKKYEEHKVT 250 Query: 255 MDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLEN----TAVDLFGAGTETTSTTLRYAL 310 N +D +D L ++N S + E+ T ++FGAG ETT+TTL++++ Sbjct: 251 YSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGAGVETTTTTLKWSI 310 Query: 311 LLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAV 370 L+ +P+V K+QEE++ IG+ R P + DR ++PY +A + EV R + P +PH Sbjct: 311 AYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSPLLIPHVA 370 Query: 371 TCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK--KSKYFMPF 428 D Y + KGT ++I++ S+ HD KE+ NPE+FDP FL+E G+ S ++PF Sbjct: 371 LQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPF 430 Query: 429 SAGKRICVGEALAGMELFLFLTSILQNFNLK 459 AG R+C+GEALA MELFLFL ILQ F L+ Sbjct: 431 GAGVRVCLGEALAKMELFLFLAWILQRFTLE 461 >6IQ5-A nrPDB Length = 463 Score = 233 bits (593), Expect = 2e-61, Method: Compositional matrix adjust. Identities = 142/429 (33%), Positives = 228/429 (53%), Gaps = 27/429 (6%) Query: 53 SLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGI 112 S L++ YG VF + G PIVVL+G A+ +AL+ G F+ R F + G + Sbjct: 6 SFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVSGGRSM 65 Query: 113 VFSN-GKKWKEIRRFSLMTLRNF----GMGKRSIEDRVQEEARCLVEELRKTKASPC--D 165 F + + WK RR + +RNF ++ +E V EAR LV L + A D Sbjct: 66 AFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLD 125 Query: 166 PTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSS-------PWIQICNN 218 P + A NV+ ++ F R+ + D +F L+ E + + + PW+Q N Sbjct: 126 PRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPN 185 Query: 219 FSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNN-PQDFIDCFLMKMEK---- 273 P+ F +L +N + ++IL+K H ES+ P+D +D F++ EK Sbjct: 186 --PVRTVF-REFEQLNRNFS---NFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAG 239 Query: 274 EKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGR 333 + H + +E++ T D+FGA +T ST L++ LLL ++P+V +VQ E+++V+GR Sbjct: 240 DSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGR 299 Query: 334 NRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTS 393 +R PCM D+ ++PY A ++E R+ +P ++PHA T + Y IPK T + ++ S Sbjct: 300 DRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWS 359 Query: 394 VLHDNKEFPNPEMFDPHHFLDEGGNFKK--SKYFMPFSAGKRICVGEALAGMELFLFLTS 451 V HD ++PNPE FDP FLD+ G K + M FS GKR C+GE L+ M+LFLF++ Sbjct: 360 VNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISI 419 Query: 452 ILQNFNLKS 460 + + ++ Sbjct: 420 LAHQCDFRA 428 >4R1Z-A nrPDB Length = 439 Score = 216 bits (551), Expect = 1e-56, Method: Compositional matrix adjust. Identities = 134/407 (32%), Positives = 214/407 (52%), Gaps = 26/407 (6%) Query: 69 FGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANR-GFGIVFSN-GKKWKEIRRF 126 G +++++ + KE LI G+ F+GR + R G I F++ WK R+ Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKM 60 Query: 127 SLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKR 186 L FG G SIE + EA + E L +++ S D L A NV+C++ F+ Sbjct: 61 VHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSS 120 Query: 187 FDYKDQQFLNLMEKLNENIKILSS-------PWIQICNNFSPIIDYFPGTHNKLLKNVAF 239 + D +F ++++ + ++ PW+QI FP +L+ Sbjct: 121 YKRGDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQI----------FPNKDLTILRQCIS 170 Query: 240 MKSYILEK-VKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLEN----TAVDL 294 ++ +L+K +EH+ + N +D +D L ++N S + E+ T D+ Sbjct: 171 IRDKLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDI 230 Query: 295 FGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHE 354 FGAG ETT+T L++++ L+ +P+V K+QEE++ IG+ R P + DR ++PY +A + E Sbjct: 231 FGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIRE 290 Query: 355 VQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLD 414 V R + P +PH D Y + KGT ++I+L S+ HD KE+ NPE+FDP FL+ Sbjct: 291 VLRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLN 350 Query: 415 EGGNFK--KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLK 459 E G+ S ++PF AG R+C+GEALA MELFLFL ILQ F L+ Sbjct: 351 EEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLE 397 >2HI4-A nrPDB Length = 495 Score = 214 bits (546), Expect = 5e-56, Method: Compositional matrix adjust. Identities = 139/462 (30%), Positives = 230/462 (49%), Gaps = 24/462 (5%) Query: 28 KLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEAL 87 K PP P P++G++L +G K+ +L+ +S+ YG V + G P++VL + +++AL Sbjct: 16 KSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 74 Query: 88 IDLGEEFSGRGIFPLAERANRGFGIVFS--NGKKWKEIRRFSLMTLRNFGMGKRS----- 140 + G++F GR + G + FS +G W RR + L F + Sbjct: 75 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 134 Query: 141 --IEDRVQEEARCLVEELRKTKASPC--DPTFILGCAPCNVICSIIFHKRFDYKDQQFLN 196 +E+ V +EA+ L+ L++ A P DP + + NVI ++ F + F + L+ Sbjct: 135 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 194 Query: 197 LMEKLNENIKILSSPWIQICN--NFSPIIDYFPGTHNKLLKNVAFMKSYILEK-VKEHQE 253 L++ +E ++ SS N +F PI+ Y P + K + L+K V+EH + Sbjct: 195 LVKNTHEFVETASS-----GNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQ 249 Query: 254 SMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLL 313 D N+ +D +K + E + N D+FGAG +T +T + ++L+ L Sbjct: 250 DFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYL 309 Query: 314 LKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCD 373 + PE+ K+Q+E++ VIGR R P + DR +PY +A + E R+ LP ++PH+ T D Sbjct: 310 VTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRD 369 Query: 374 IKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGG---NFKKSKYFMPFSA 430 + IPK + ++ V HD + + +P F P FL G N S+ M F Sbjct: 370 TTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGM 429 Query: 431 GKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPV 472 GKR C+GE LA E+FLFL +LQ S+ +D TP+ Sbjct: 430 GKRRCIGEVLAKWEIFLFLAILLQQLEF-SVPPGVKVDLTPI 470 >5UYS-A nrPDB Length = 494 Score = 196 bits (497), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 125/414 (30%), Positives = 216/414 (52%), Gaps = 14/414 (3%) Query: 57 LSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGR-GIFPLAERANRGFGIVFS 115 L K YGP++++ G K V++ ++ KE LI G++FSGR + L +N GI F+ Sbjct: 38 LQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFA 97 Query: 116 N-GKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAP 174 + G W+ RR ++ T F G + +E + +E L + L D +F + A Sbjct: 98 DSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAV 157 Query: 175 CNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLL 234 NVI I F+ + D + LN+++ NE I + + + P + FP + L Sbjct: 158 TNVISLICFNTSYKNGDPE-LNVIQNYNEGI--IDNLSKDSLVDLVPWLKIFPNKTLEKL 214 Query: 235 KNVAFMKSYILEKVKE-HQESMDMNNPQDFIDCFLM-KMEKEKHNQPSEFTIESLENTAV 292 K+ +++ +L K+ E ++E ++ + +D + KM + N + E L + + Sbjct: 215 KSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHI 274 Query: 293 -----DLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPY 347 D+FGAG ETT++ +++ L LL +P+V K+ EEI++ +G +R+P + DR+ + Sbjct: 275 LTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLL 334 Query: 348 TDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMF 407 +A + EV R + P +PH D + + KGT ++I+L ++ H+ KE+ P+ F Sbjct: 335 LEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQF 394 Query: 408 DPHHFLDEGGN--FKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLK 459 P FL+ G S ++PF AG R C+GE LA ELFL + +LQ F+L+ Sbjct: 395 MPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 448 >5VBU-A nrPDB Length = 476 Score = 184 bits (468), Expect = 5e-47, Method: Compositional matrix adjust. Identities = 132/450 (29%), Positives = 224/450 (49%), Gaps = 31/450 (6%) Query: 21 RQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGY 80 +++S +GKLPP + L + D+ L L++ +GP++ L+ GL+ +VVL+ Sbjct: 3 KKTSSKGKLPP------LAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSK 56 Query: 81 EAVKEALIDLGEEFSGRG---IFPLAER--ANRGFGIVFSNGKKWKEIRRFSLMTLRNFG 135 ++EA++ +F+GR + L R + G K K++ R +L+ Sbjct: 57 RTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALL------ 110 Query: 136 MGKR-SIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQF 194 +G R S+E V++ + E +R +P C++IC + F + KD Sbjct: 111 LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKI--KDDNL 168 Query: 195 LNLMEK-LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILE-KVKEHQ 252 + K + E +K S IQI + P + +FP + LK + +I+E ++++H+ Sbjct: 169 MPAYYKCIQEVLKTWSHWSIQIVDVI-PFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHK 227 Query: 253 ESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIES-LENTAVDLFGAGTETTSTTLRYALL 311 ES+ +D +D L + + + S +E + AVDL GTETT+ TL +A++ Sbjct: 228 ESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVV 287 Query: 312 LLLKHPEVTAKVQEEIERVIGRNRSPC---MQDRSHMPYTDAVVHEVQRYIDLLPTSLPH 368 LL HPE+ ++QEE++ +G S +DR+ +P +A + EV R ++P +LPH Sbjct: 288 FLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPH 347 Query: 369 AVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPF 428 T Y IP+GT I+ +L D + P F P FL+ G N + + F Sbjct: 348 RTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRA----LAF 403 Query: 429 SAGKRICVGEALAGMELFLFLTSILQNFNL 458 G R+C+GE LA +ELF+ LT +LQ F L Sbjct: 404 GCGARVCLGEPLARLELFVVLTRLLQAFTL 433 >3QZ1-A nrPDB Length = 496 Score = 175 bits (444), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 124/433 (28%), Positives = 212/433 (48%), Gaps = 25/433 (5%) Query: 37 PVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSG 96 P++ L + ++ L +L++ GPV+ L GL+ +VVL+ ++EA+I +F+G Sbjct: 32 PLVPGFLHLLQPNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAG 91 Query: 97 RGIFP----LAERANR-GFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRS-IEDRVQEEAR 150 R P +++R G K K++ R +L+ +G RS +E V + + Sbjct: 92 RPQIPSYKLVSQRCQDISLGDYSLLWKAHKKLTRSALL------LGTRSSMEPWVDQLTQ 145 Query: 151 CLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSS 210 E +R +P C++IC + F + D F + ++ L + S Sbjct: 146 EFCERMRVQAGAPVTIQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQDLMKTWDHWS- 204 Query: 211 PWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEK-VKEHQESMDMNNPQDFIDCFLM 269 IQI + P + +FP LK + +++EK ++ H+ESM +D D L Sbjct: 205 --IQILD-MVPFLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDMTDYMLQ 261 Query: 270 KMEKEKHNQ-PSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIE 328 + +++ + P + + + VDLF GTETT++TL +A+ LL HPE+ ++QEE++ Sbjct: 262 GVGRQRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEELD 321 Query: 329 RVIGRNRS---PCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGT 385 R +G S +DR+ +P +A + EV R ++P +LPH T Y IP+G Sbjct: 322 RELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGM 381 Query: 386 TILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMEL 445 ++ +L D + P F P FL+ G N + F G R+C+GE+LA +EL Sbjct: 382 VVIPNLQGAHLDETVWEQPHEFRPDRFLEPGANPSA----LAFGCGARVCLGESLARLEL 437 Query: 446 FLFLTSILQNFNL 458 F+ L +LQ F L Sbjct: 438 FVVLARLLQAFTL 450 >5YLW-A nrPDB Length = 495 Score = 156 bits (394), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 130/490 (26%), Positives = 229/490 (46%), Gaps = 60/490 (12%) Query: 1 MDS---LVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNL 57 MDS L L + + LS R R LPPGP P P++GN+LQ+G + + L Sbjct: 1 MDSFPLLAALFFIAATITFLSFRR----RRNLPPGPFPYPIVGNMLQLG-ANPHQVFAKL 55 Query: 58 SKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLA-----ERANRGFGI 112 SK YGP+ +++ G V++ E KE L G+ FSGR I ++ + GF Sbjct: 56 SKRYGPLMSIHLGSLYTVIVSSPEMAKEILHRHGQVFSGRTIAQAVHACDHDKISMGFLP 115 Query: 113 VFSNGKKWKEIRR------FSLMTLR-NFGMGKRSIEDRVQEEARCLVEELRKTKASPCD 165 V S +W+++R+ FS ++ + G+ ++ ++ + +C D Sbjct: 116 VAS---EWRDMRKICKEQMFSNQSMEASQGLRRQKLQQLLDHVQKC------SDSGRAVD 166 Query: 166 PTFILGCAPCNVICSIIFHKRF-DYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIID 224 N++ + +F + ++ + + E + I+ P NF+ D Sbjct: 167 IREAAFITTLNLMSATLFSSQATEFDSKATMEFKEIIEGVATIVGVP------NFA---D 217 Query: 225 YFP--------GTHNK----LLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKME 272 YFP G + K +A ++ Y+ E+++ + + + DF++ + + Sbjct: 218 YFPILRPFDPQGVKRRADVFFGKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDII- 276 Query: 273 KEKHNQPSEFTIESLENT--AVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERV 330 Q +EF +++ T +DLF G++T +T++ +A+ L+ +P+ A+++ E++ V Sbjct: 277 -----QANEFKLKTHHFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSV 331 Query: 331 IGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILIS 390 G + +PY AV+ EV R P LP D + YLIPKGT ILI+ Sbjct: 332 AGDEKIVDESAMPKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILIN 391 Query: 391 LTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKY-FMPFSAGKRICVGEALAGMELFLFL 449 ++ D + +PE FDP FLD +FK Y +PF +G+R+C G LA L + Sbjct: 392 AYAIGRDPSIWTDPETFDPERFLDNKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMAT 451 Query: 450 TSILQNFNLK 459 +++ NF+ K Sbjct: 452 ATLVHNFDWK 461 >6DA2-A nrPDB Length = 487 Score = 127 bits (318), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 129/456 (28%), Positives = 198/456 (43%), Gaps = 55/456 (12%) Query: 31 PGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALI-D 89 PGPTPLP +GNIL K K YG V+ Y G +P++ + + +K L+ + Sbjct: 19 PGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 77 Query: 90 LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK-RSIEDRVQEE 148 F+ R P I + ++WK +R SL++ F GK + + + + Sbjct: 78 CYSVFTNRR--PFGPVGFMKSAISIAEDEEWKRLR--SLLS-PTFTSGKLKEMVPIIAQY 132 Query: 149 ARCLVEELRKTKAS--PCDPTFILGCAPCNVICSIIFHK--------------------R 186 LV LR+ + P + G +VI S F R Sbjct: 133 GDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR 192 Query: 187 FDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFP-GTHNKLLKNVAFMKSYIL 245 FD+ D FL++ + P +++ N I FP N L K+V MK L Sbjct: 193 FDFLDPFFLSI------TVFPFLIPILEVLN-----ICVFPREVTNFLRKSVKRMKESRL 241 Query: 246 EKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTT 305 E ++H+ ++ Q ID K E E H S+ +E + + + +F AG ETTS+ Sbjct: 242 EDTQKHR----VDFLQLMIDSQNSK-ETESHKALSD--LELVAQSIIFIF-AGYETTSSV 293 Query: 306 LRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTS 365 L + + L HP+V K+QEEI+ V+ P M Y D VV+E R L P + Sbjct: 294 LSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLR---LFPIA 350 Query: 366 LPHAVTC--DIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSK 423 + C D++ IPKG ++I ++ D K + PE F P F + + Sbjct: 351 MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 410 Query: 424 YFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLK 459 + PF +G R C+G A M + L L +LQNF+ K Sbjct: 411 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 446 >5VEU-A nrPDB Length = 480 Score = 126 bits (316), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 132/458 (28%), Positives = 202/458 (44%), Gaps = 37/458 (8%) Query: 31 PGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALI-D 89 PGPTPLP++GN+L + + K T K YG ++ Y G P++ + + ++ L+ + Sbjct: 18 PGPTPLPLLGNVLSYR-QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 76 Query: 90 LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK-RSIEDRVQEE 148 F+ R L I + ++WK IR SL++ F GK + + + + Sbjct: 77 CYSVFTNRR--SLGPVGFMKSAISLAEDEEWKRIR--SLLS-PTFTSGKLKEMFPIIAQY 131 Query: 149 ARCLVEELRKT--KASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIK 206 LV LR+ K P I G +VI F D + +E + +K Sbjct: 132 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK 191 Query: 207 I--LSSPWIQIC--NNFSPI-----IDYFP-GTHNKLLKNVAFMKSYILEKVKEHQESMD 256 L ++ I +P+ + FP T N L K+V MK L ++H+ Sbjct: 192 FGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHR---- 247 Query: 257 MNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKH 316 ++ Q ID K E E H S+ L ++ AG ETTS+ L + L L H Sbjct: 248 LDFLQLMIDSQNSK-ETESHKALSDL---ELAAQSIIFIFAGYETTSSVLSFTLYELATH 303 Query: 317 PEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTC--DI 374 P+V K+Q+EI+ V+ P M Y D VV+E R L P ++ TC D+ Sbjct: 304 PDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR---LFPVAIRLERTCKKDV 360 Query: 375 KFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRI 434 + IPKG+ ++I ++ HD K + PE F P F + + Y PF G R Sbjct: 361 EINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY-TPFGTGPRN 419 Query: 435 CVGEALAGMELFLFLTSILQNFNLKSLVD---PKNLDT 469 C+G A M + L L +LQNF+ K + P LDT Sbjct: 420 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDT 457 >3K9V-A nrPDB Length = 482 Score = 96.7 bits (239), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 100/440 (22%), Positives = 190/440 (43%), Gaps = 25/440 (5%) Query: 31 PGPTPLPVIGNILQI----GIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEA 86 PGPT P++G++L+I G+K +L K YG +F + G V L G ++ EA Sbjct: 27 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHL-GSPSLLEA 85 Query: 87 LIDLGEEFSGR-GIFPLA---ERANRGFGIVFSNGKKWKEIRR-FSLMTLRNFGMGKRSI 141 L R I P + N +G++ G++W+ +R F ++ + K + Sbjct: 86 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK--L 143 Query: 142 EDRVQEEARCLVE---ELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLM 198 + ++ E +E EL + D L IC +++ KRF ++ Sbjct: 144 DKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEA 203 Query: 199 EKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMN 258 IK + S + ++ +P+ + + K+ + I + VK ++ Sbjct: 204 LTFITAIKTMMSTFGKMM--VTPV-ELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQR 260 Query: 259 NPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPE 318 Q FL + ++ H + + L +L A ETT+ +L + L L ++P+ Sbjct: 261 YSQQPGADFLCDIYQQDH-----LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQ 315 Query: 319 VTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRN 378 ++ +E++ V+ N++P +D +MPY A + E R +P + + Sbjct: 316 AQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT-RTLDKPTVLGE 374 Query: 379 YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGE 438 Y +PKGT + ++ + F + F P +L + + +PF GKR+C+G Sbjct: 375 YALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAH-LPFGIGKRMCIGR 433 Query: 439 ALAGMELFLFLTSILQNFNL 458 LA ++L L L I+Q +++ Sbjct: 434 RLAELQLHLALCWIIQKYDI 453 >3MDV-A nrPDB Length = 456 Score = 85.9 bits (211), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 93/442 (21%), Positives = 181/442 (40%), Gaps = 60/442 (13%) Query: 44 QIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID-------------- 89 ++G + + + +K YGPV + K V++ E+VK+ L+ Sbjct: 6 EVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQ 65 Query: 90 --LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQE 147 GE G+G+ + N ++W + RR + + S+ + E Sbjct: 66 TVFGERLFGQGL------------VSECNYERWHKQRRVIDLAFSRSSLV--SLMETFNE 111 Query: 148 EARCLVE--ELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENI 205 +A LVE E + +P +L +++ F + L + L++ + Sbjct: 112 KAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAF----GMETSMLLGAQKPLSQAV 167 Query: 206 KILSSPWIQICNNFSPIIDYFPGTHNKLLK---NVAFMKSYILEKVKEHQESMDMNN--P 260 K++ I + + + + PG +L + ++ F++ + V+ +E++ P Sbjct: 168 KLMLEG---ITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVP 224 Query: 261 QDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVT 320 D + L E + + E L + V F AG ET++ L + ++ L + PE+ Sbjct: 225 ADILTQILKAEEGAQDD-------EGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIV 277 Query: 321 AKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLP--HAVTCDIKFRN 378 A++Q E++ VIG R +D + Y V+ E R L P + + + Sbjct: 278 ARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLR---LYPPAWGTFRLLEEETLIDG 334 Query: 379 YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKY-FMPFSAGKRICVG 437 +P T +L S + + F +P F+P F G K ++ + PFS G R C+G Sbjct: 335 VRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRF---GPGAPKPRFTYFPFSLGHRSCIG 391 Query: 438 EALAGMELFLFLTSILQNFNLK 459 + A ME+ + + +LQ + Sbjct: 392 QQFAQMEVKVVMAKLLQRLEFR 413 >2VE3-A nrPDB Length = 444 Score = 85.9 bits (211), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 70/287 (24%), Positives = 137/287 (47%), Gaps = 14/287 (4%) Query: 185 KRFDYKDQQFLNLMEKLNENIKILSSPWIQ--ICNNFSPIIDYFPGTHNKLLKNVAFMKS 242 +R + L + EK+++N ++ PW + I FS I N L ++ Sbjct: 148 RRMTFDVAATLFMGEKVSQNPQLF--PWFETYIQGLFSLPIPL----PNTLFGKSQRARA 201 Query: 243 YILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETT 302 +L ++++ ++ P + ++ ++ +NQP ++ L++ + L AG ET Sbjct: 202 LLLAELEKIIKARQQQPPSEEDALGILLAARDDNNQP--LSLPELKDQILLLLFAGHETL 259 Query: 303 STTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLL 362 ++ L LLL +H ++ +V++E + + ++ + MPY D V+ EV R I + Sbjct: 260 TSALSSFCLLLGQHSDIRERVRQE-QNKLQLSQELTAETLKKMPYLDQVLQEVLRLIPPV 318 Query: 363 PTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS 422 + D +F+ + PKG + ++ D +P+PE FDP F +G Sbjct: 319 GGGF-RELIQDCQFQGFHFPKGWLVSYQISQTHADPDLYPDPEKFDPERFTPDGSATHNP 377 Query: 423 KY-FMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLD 468 + +PF G R C+G+ A +E+ LF T ++Q F+ +L+ +NL+ Sbjct: 378 PFAHVPFGGGLRECLGKEFARLEMKLFATRLIQQFDW-TLLPGQNLE 423 >6AYB-A nrPDB Length = 466 Score = 82.8 bits (203), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 108/459 (23%), Positives = 200/459 (43%), Gaps = 48/459 (10%) Query: 19 LWRQSSGRGKLPPG-PTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVL 77 + +++S +GKLPP P +P +G+ + K+ + + + SK YG VFT K + L Sbjct: 1 MAKKTSSKGKLPPRVPNLIPYVGSFVSFA-KNPVQFIIDNSKKYGDVFTATILGKEMTFL 59 Query: 78 HGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFS--NGKKWKEIRRF--SLMTLRN 133 + + + E S R ++ R G G+V+ + ++ E +F S +T Sbjct: 60 NHPKILDTFFKATDNELSLRDVYRFM-RPVFGTGVVYDADSTERMMEQVKFVSSGLTTAR 118 Query: 134 FGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQ 193 F + ED + + + L E A I + C + + +Q Sbjct: 119 FRVFVDIFEDEIAHKVKELGPEGTVDVAELMADLIIFTASRCLLGDEV----------RQ 168 Query: 194 FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPG----THNKLLKNVAFMKSYILEKVK 249 +L+ K L + I + SP+ ++P +K K V + +L+K + Sbjct: 169 YLSE--------KNLGKLYHDIDDGISPLSFFYPSLPAPKRDKARKAVGEIFQELLDKRR 220 Query: 250 E----HQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFT-IESLENTAVDLFGAGTETTST 304 E H E + + D +D L +K+ E T + + LF AG T+S Sbjct: 221 EEHKKHPERLLDESKMDVVDHLLT----QKYKDGQELTDVHRIGILIAGLF-AGQHTSSI 275 Query: 305 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPT 364 T + L+ ++ + +V KV++E E ++G ++ M Y +A + E R L Sbjct: 276 TSSWTLMNVISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPPLIM 335 Query: 365 SLPHAVT---CDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKK 421 + A C+ Y+IPKG +++S + + NP++FDP L E +K Sbjct: 336 IMRMARKPRECE----QYIIPKGNILVVSPSVAGRCTDTYTNPDVFDPER-LTERKEHEK 390 Query: 422 SKY-FMPFSAGKRICVGEALAGMELFLFLTSILQNFNLK 459 KY +PF AG+ C+GE A +++ ++ +L+ F+++ Sbjct: 391 FKYGAVPFGAGRHKCIGENFALLQVKSIISILLRYFDME 429 >3S79-A nrPDB Length = 503 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 51/185 (27%), Positives = 93/185 (50%), Gaps = 13/185 (7%) Query: 280 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339 + T E++ +++ A +T S +L + L L+ KHP V + +EI+ VIG R + Sbjct: 289 GDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-ERDIKI 347 Query: 340 QDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNK 399 D + + ++E RY ++ + A+ D+ Y + KGT I++++ +H + Sbjct: 348 DDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDV-IDGYPVKKGTNIILNIGR-MHRLE 405 Query: 400 EFPNPEMFDPHHFLDEGGNFKKS---KYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456 FP P F NF K+ +YF PF G R C G+ +A + + L ++L+ F Sbjct: 406 FFPKPNEFTLE-------NFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 Query: 457 NLKSL 461 ++K+L Sbjct: 459 HVKTL 463 >3EL3-A nrPDB Length = 467 Score = 71.6 bits (174), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 49/200 (24%), Positives = 86/200 (43%), Gaps = 6/200 (3%) Query: 265 DCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQ 324 D L + + K + + + + V + G+ET ++T+ + L L HPE +++ Sbjct: 242 DDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIR 301 Query: 325 EEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTS--LPHAVTCDIKFRNYLIP 382 +E+E V G R +D + +T V+ E R L P L + + Y IP Sbjct: 302 DEVEAVTG-GRPVAFEDVRKLRHTGNVIVEAMR---LRPAVWVLTRRAVAESELGGYRIP 357 Query: 383 KGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAG 442 G I+ S ++ D K + + FDP +L E PFSAGKR C + + Sbjct: 358 AGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSM 417 Query: 443 MELFLFLTSILQNFNLKSLV 462 +L L ++ + + + Sbjct: 418 AQLTLITAALATKYRFEQVA 437 >3N9Z-A nrPDB Length = 487 Score = 71.2 bits (173), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 48/186 (25%), Positives = 93/186 (50%), Gaps = 14/186 (7%) Query: 280 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339 S+ + E ++ ++ G +TTS TL++ L + ++ KVQ+ + + R Sbjct: 269 SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARN----LKVQDMLRAEVLAARHQAQ 324 Query: 340 QDRSHM----PYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVL 395 D + M P A + E R + + +L + D+ R+Y+IP T + +++ ++ Sbjct: 325 GDMATMLQLVPLLKASIKETLR-LHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALG 383 Query: 396 HDNKEFPNPEMFDPHHFLDEGGNFKKSKYF--MPFSAGKRICVGEALAGMELFLFLTSIL 453 + F +PE FDP +L + N YF + F G R C+G +A +E+ +FL ++L Sbjct: 384 REPTFFFDPENFDPTRWLSKDKNI---TYFRNLGFGWGVRQCLGRRIAELEMTIFLINML 440 Query: 454 QNFNLK 459 +NF ++ Sbjct: 441 ENFRVE 446 >6C94-A nrPDB Length = 497 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 59/225 (26%), Positives = 107/225 (47%), Gaps = 11/225 (4%) Query: 245 LEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFG-AGTETTS 303 L+ KE +E + DF+D L+ + E Q S+ + + VD F G +TT+ Sbjct: 246 LQDEKE-REKIQNRRHLDFLD-ILLDVRGESGVQLSDTDLRA----EVDTFMFEGHDTTT 299 Query: 304 TTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP 363 + + + L + +PE + +EE+ ++G S +D + M Y + E R +P Sbjct: 300 SGISWFLYCMALYPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVP 359 Query: 364 TSLPHAVTCDIKFRN-YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS 422 + ++ + F + +P G+ I + + ++ ++ +P+PE+FDP F E + + Sbjct: 360 -QVYRQLSKPVSFVDGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRHP 418 Query: 423 KYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNL 467 F+PFSAG R C+G+ A E+ + L F VDP L Sbjct: 419 YAFIPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFS--VDPLRL 461 >3MZS-A nrPDB Length = 486 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 44/176 (25%), Positives = 85/176 (48%), Gaps = 2/176 (1%) Query: 284 IESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRS 343 +E ++ ++ G TTS TL++ L + + V ++EE+ + + Sbjct: 274 LEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQ 333 Query: 344 HMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPN 403 +P A + E R + + +L D+ ++YLIP T + +++ ++ D F + Sbjct: 334 MVPLLKASIKETLR-LHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSS 392 Query: 404 PEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLK 459 P+ FDP +L + + + + F G R CVG +A +E+ LFL IL+NF ++ Sbjct: 393 PDKFDPTRWLSKDKDLIHFRN-LGFGWGVRQCVGRRIAELEMTLFLIHILENFKVE 447 >4ZGX-A nrPDB Length = 489 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 79/363 (21%), Positives = 146/363 (40%), Gaps = 52/363 (14%) Query: 102 LAERANRGF--GIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIED---RVQEEARCLVEEL 156 +A R +RG G+ NG +W RF+ + L + ++++ V AR + L Sbjct: 94 VAYRQHRGHKCGVFLLNGPEW----RFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQAL 149 Query: 157 RKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQIC 216 +K + L P IFH + + + E + ++ Sbjct: 150 KKKVLQNARGSLTLDVQPS------IFHYTIEASN------LALFGERLGLVGHSPSSAS 197 Query: 217 NNFSPIIDYFPGTHNKLLKNVAFMKSYILEKV-KEHQESMD------------------M 257 NF ++ + +L+ + +I KV KEH E+ D Sbjct: 198 LNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAF 257 Query: 258 NNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 317 N PQ + + K +E ++E+++ +++L +TT+ L L L ++P Sbjct: 258 NRPQHYTGIVAELLLK------AELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNP 311 Query: 318 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSL--PHAVTCDIK 375 +V +++E + + +P A + E R L P L V+ D+ Sbjct: 312 DVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLR---LYPVGLFLERVVSSDLV 368 Query: 376 FRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRIC 435 +NY IP GT + + L S+ + FP PE ++P +LD G+ ++ + +PF G R C Sbjct: 369 LQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGS-GRNFHHVPFGFGMRQC 427 Query: 436 VGE 438 +G Sbjct: 428 LGR 430 >2WX2-A nrPDB Length = 473 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 91/443 (20%), Positives = 173/443 (39%), Gaps = 34/443 (7%) Query: 30 PPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID 89 P P +P +G+I+Q G + + VFT+ G + + ++ Sbjct: 19 PVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSRFFSP 78 Query: 90 LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK-RSIEDRVQEE 148 E S R ++ + FG + + +R + K ++ +Q E Sbjct: 79 RNEILSPREVYTIMTPV---FGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHE 135 Query: 149 ARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHK--RFDYKDQQFLNLMEKLNENIK 206 R + E K + G N C +F + R + F L+ K+ ++ Sbjct: 136 VRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSKMESSLI 195 Query: 207 ILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKV---KEHQESMDMNNPQDF 263 + F P + P + + IL ++ +E +E+ NN D Sbjct: 196 PAAV--------FMPWLLRLPLPQSARCREARAELQKILGEIIVAREKEEASKDNNTSDL 247 Query: 264 IDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLL--KHPEVTA 321 + L K + + ++ + V AG T++ T +++L L+ K+ + Sbjct: 248 LGGLL----KAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLD 303 Query: 322 KVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHE-VQRYIDLLPTSLPHAVTCDIKFRNYL 380 K+ +EI+ + + D MP+ + V E ++R LL + V ++K +Y+ Sbjct: 304 KLHKEIDEFPAQLNYDNVMD--EMPFAERCVRESIRRDPPLL--MVMRMVKAEVKVGSYV 359 Query: 381 IPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEAL 440 +PKG I S HD + FPNP ++DP DE K F+ F AG C+G+ Sbjct: 360 VPKGDIIACSPLLSHHDEEAFPNPRLWDPER--DE----KVDGAFIGFGAGVHKCIGQKF 413 Query: 441 AGMELFLFLTSILQNFNLKSLVD 463 A +++ L + + ++ + L D Sbjct: 414 ALLQVKTILATAFREYDFQLLRD 436 >5FOI-A nrPDB Length = 408 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 50/176 (28%), Positives = 80/176 (45%), Gaps = 28/176 (15%) Query: 280 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339 E T + L N AV L AG ET++ + ++L LL+HPE A+++E+ E Sbjct: 230 GEITHQELVNNAVLLLAAGHETSANQVTLSVLTLLRHPETAAELREQPEL---------- 279 Query: 340 QDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNK 399 MP V E+ RY + L A T DI ++ I G ++I L+S HD Sbjct: 280 -----MPN---AVDELLRYHS-IADGLRRAATADIVLGDHTIRAGDGLIILLSSANHDGN 330 Query: 400 EFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQN 455 F FD H + +++ + F G C+G+ LA +E+ + L + + Sbjct: 331 TFGAEATFDIH---------RPARHHVAFGYGPHQCLGQNLARLEMEVTLGKLFRR 377 >5FSA-A nrPDB Length = 490 Score = 65.1 bits (157), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 57/245 (23%), Positives = 110/245 (44%), Gaps = 32/245 (13%) Query: 245 LEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTST 304 ++++K +E D++ +D ID L+ + + T + + N + + G T+++ Sbjct: 216 MKEIKLRRERGDIDPNRDLIDSLLIH---STYKDGVKMTDQEIANLLIGILMGGQHTSAS 272 Query: 305 TLRYALLLLLKHPEVTAKVQEEIERVI----GRNRSPCMQDRSHMPYTDAVVHEVQRYID 360 T + LL L + P + + +E+ ++ G +D +P + + E R + Sbjct: 273 TSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLR-MH 331 Query: 361 LLPTSLPHAVTCDIKF--RNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHF------ 412 + S+ VT ++ NY++PKG +L+S + F NPE FDP + Sbjct: 332 MPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAK 391 Query: 413 -----------LDEG-GNFKK--SKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458 +D G G K S ++PF G+ C+GE A ++L LT+ + +NL Sbjct: 392 ANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFV--YNL 449 Query: 459 KSLVD 463 + +D Sbjct: 450 RWTID 454 >4KPA-A nrPDB Length = 494 Score = 62.8 bits (151), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 50/166 (30%), Positives = 76/166 (45%), Gaps = 6/166 (3%) Query: 297 AGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQ 356 AG ETTS L +AL L+K+P V K EE RV+ + P + + Y V++E Sbjct: 288 AGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVL-VDPVPSYKQVKQLKYVGMVLNEAL 346 Query: 357 RYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEF--PNPEMFDPHHFLD 414 R P +A + Y + KG +++ L LH +K + E F P F Sbjct: 347 RLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMV-LIPQLHRDKTIWGDDVEEFRPERF-- 403 Query: 415 EGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKS 460 E + F PF G+R C+G+ A E L L +L++F+ + Sbjct: 404 ENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFED 449 >5JLC-A nrPDB Length = 515 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 68/299 (22%), Positives = 126/299 (42%), Gaps = 35/299 (11%) Query: 197 LMEKLNENIKILSSPWIQICNNFSPIIDYFPGT----HNKLLKNVAFMKSYILEKVKEHQ 252 + +KL+ + L S + F+PI FP + K + + +KE + Sbjct: 199 MRDKLDTDFAYLYS---DLDKGFTPINFVFPNLPLEHYRKRDHAQQAISGTYMSLIKERR 255 Query: 253 ESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLL 312 E D+ N +D ID M+ + ++ T + + N + + G T++ T + LL Sbjct: 256 EKNDIQN-RDLIDEL---MKNSTYKDGTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLH 311 Query: 313 LLKHPEVTAKVQEEIERVIGRN-RSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVT 371 L + P+V ++ +E RV+ + + D +MP + ++ E R L SL V Sbjct: 312 LAERPDVQEELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPL-HSLFRKVM 370 Query: 372 CDIKFRN--YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHF--------------LDE 415 D+ N Y++P+ +L+S + FP P F+ H + +D Sbjct: 371 RDVAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDY 430 Query: 416 G-GNFKK--SKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTP 471 G G K S ++PF G+ C+GE A +L + ++ ++ + P +T P Sbjct: 431 GFGAISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRY---PTEGETVP 486 >6M7X-A nrPDB Length = 484 Score = 61.6 bits (148), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 41/161 (25%), Positives = 75/161 (46%), Gaps = 6/161 (3%) Query: 280 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339 +E + ++++ +++L +TT L L L ++P V +++E Sbjct: 274 AELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQ 333 Query: 340 QDRSHMPYTDAVVHEVQRYIDLLPTSL--PHAVTCDIKFRNYLIPKGTTILISLTSVLHD 397 + + +P A + E R L P L + D+ +NY IP GT + + L S+ + Sbjct: 334 KATTELPLLRAALKETLR---LYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRN 390 Query: 398 NKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGE 438 FP PE ++P +LD G+ ++ Y +PF G R C+G Sbjct: 391 PALFPRPERYNPQRWLDIRGS-GRNFYHVPFGFGMRQCLGR 430 >4WMZ-A nrPDB Length = 539 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 56/228 (24%), Positives = 100/228 (43%), Gaps = 24/228 (10%) Query: 248 VKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLR 307 +KE +++ D+ + +D ID M+ + + T + + N + + G T++ T Sbjct: 269 IKERRKNNDIQD-RDLIDSL---MKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSA 324 Query: 308 YALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQD-RSHMPYTDAVVHEVQRYIDLLPTSL 366 + LL L + P+V ++ EE RV+ + D MP + + E R L SL Sbjct: 325 WILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPL-HSL 383 Query: 367 PHAVTCDIKFRN--YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHF------------ 412 V D+ N Y+IP G +L+S ++ FPN F+ H + Sbjct: 384 FRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGE 443 Query: 413 -LDEG-GNFKK--SKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456 +D G G K S ++PF G+ C+GE A +L + ++ ++ Sbjct: 444 EVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTL 491 >3L4D-A nrPDB Length = 453 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 104/455 (22%), Positives = 183/455 (40%), Gaps = 53/455 (11%) Query: 26 RGKLPP---GPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEA 82 +GKLPP G TP +G+I+Q G KD + K YG +FT+ I V+ Sbjct: 1 KGKLPPVVHGTTPF--VGHIIQFG-KDPLGFMLKAKKKYGGIFTMNICGNRITVVGDVHQ 57 Query: 83 VKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNG-KKWKEIRRF--SLMTLRNFGMGKR 139 + E S R ++ G G+ ++ + +E F +T+ F Sbjct: 58 HSKFFTPRNEILSPREVYSFMVPVF-GEGVAYAAPYPRMREQLNFLAEELTVAKFQNFAP 116 Query: 140 SIEDRVQE--EARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF----HKRFDYKDQQ 193 SI+ V++ +A +E C I N C +F KR D + Q Sbjct: 117 SIQHEVRKFMKANWNKDEGEINILDDCSAMII------NTACQCLFGEDLRKRLDAR--Q 168 Query: 194 FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKV---KE 250 F L+ K+ E+ I ++ F P I P + ++ IL ++ +E Sbjct: 169 FAQLLAKM-ESCLIPAA-------VFLPWILKLPLPQSYRCRDARAELQDILSEIIIARE 220 Query: 251 HQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYAL 310 +E+ N D + L + ++ + + + V AG T++ T ++L Sbjct: 221 KEEAQKDTNTSDLLAGLLGAVYRDG----TRMSQHEVCGMIVAAMFAGQHTSTITTTWSL 276 Query: 311 LLLL--KHPEVTAKVQEEIERVIGR-NRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLP 367 L L+ ++ AK+ +EI+ + N M++ MP+ + E R D L Sbjct: 277 LHLMDPRNKRHLAKLHQEIDEFPAQLNYDNVMEE---MPFAEQCARESIRR-DPPLVMLM 332 Query: 368 HAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK-KSKYFM 426 V ++ Y++P+G I S D + FPNP ++P N K F Sbjct: 333 RKVLKPVQVGKYVVPEGDIIACSPLLSHQDEEAFPNPREWNPER------NMKLVDGAFC 386 Query: 427 PFSAGKRICVGEALAGMELFLFLTSILQNFNLKSL 461 F AG C+GE +++ L ++L++++ + L Sbjct: 387 GFGAGVHKCIGEKFGLLQVKTVLATVLRDYDFELL 421 >2ZBZ-A nrPDB Length = 412 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 46/185 (24%), Positives = 80/185 (43%), Gaps = 27/185 (14%) Query: 280 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339 E E L +TA+ L AG ETT++ +++ LL HPE A ++ Sbjct: 227 GEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALR--------------- 271 Query: 340 QDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNK 399 DRS +P V E+ RY+ + + T DI+ LI G +++ + D Sbjct: 272 ADRSLVP---GAVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRDGT 328 Query: 400 EFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLK 459 + +P+ D H + +++ + F G C+G+ LA +EL + L +++ Sbjct: 329 VYEDPDALDIH---------RSARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTL 379 Query: 460 SLVDP 464 L P Sbjct: 380 RLAVP 384 >2X2N-A nrPDB Length = 475 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 49/173 (28%), Positives = 77/173 (44%), Gaps = 19/173 (10%) Query: 297 AGTETTSTTLRYALLLLL-----KHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAV 351 AG T+S T +++L L+ KH E K EE + N MP+ + Sbjct: 277 AGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEFPAQLNYNNV-----MDEMPFAERC 331 Query: 352 VHE-VQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPH 410 E ++R LL L V D+K +Y++PKG I S HD + FP P +DP Sbjct: 332 ARESIRRDPPLL--MLMRKVMADVKVGSYVVPKGDIIACSPLLSHHDEEAFPEPRRWDPE 389 Query: 411 HFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVD 463 DE K F+ F AG C+G+ +++ L + ++++ + L D Sbjct: 390 R--DE----KVEGAFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQLLRD 436 >3TYW-A nrPDB Length = 417 Score = 57.8 bits (138), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 50/181 (27%), Positives = 80/181 (44%), Gaps = 29/181 (16%) Query: 276 HNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNR 335 H P T E L +T AG ETT++ + + LLLL PE+ A+++ Sbjct: 228 HLVPGNVTTEQLLSTLGITINAGRETTTSMIALSTLLLLDRPELPAELR----------- 276 Query: 336 SPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTC-DIKFRNYLIPKGTTILISLTSV 394 +D MP A V E+ R + + S+P V DI+ +P ++ L Sbjct: 277 ----KDPDLMP---AAVDELLRVLSVA-DSIPLRVAAEDIELSGRTVPADDGVIALLAGA 328 Query: 395 LHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQ 454 HD ++F +PE D H + + + F G CVG+ LA +EL + L ++L+ Sbjct: 329 NHDPEQFDDPERVDFH---------RTDNHHVAFGYGVHQCVGQHLARLELEVALETLLR 379 Query: 455 N 455 Sbjct: 380 R 380 >6B11-A nrPDB Length = 440 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 44/168 (26%), Positives = 76/168 (45%), Gaps = 28/168 (16%) Query: 289 NTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYT 348 + AV L AG ETT++ + ++L+LL+HP ++ +P + +P Sbjct: 271 DNAVLLLAAGHETTASMVTMSVLVLLQHPTAWREL----------TVNPGL-----LP-- 313 Query: 349 DAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFD 408 V E+ RY+ + L + T DI+ + I G ++ L + D F PE FD Sbjct: 314 -GAVDELLRYLSIA-DGLRRSATADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFD 371 Query: 409 PHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456 H + ++ + F G C+G+ LA MEL + L ++L+ Sbjct: 372 IH---------RSARRHVAFGYGPHQCLGQNLARMELEVALGAVLERL 410 >4OQR-A nrPDB Length = 457 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 52/178 (29%), Positives = 77/178 (43%), Gaps = 32/178 (17%) Query: 280 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339 ++ T E L N A+ L AG ETT+ L LL+HPE A + SP Sbjct: 262 TDLTDEELTNIALILLVAGHETTANMLGLGTFALLQHPEQIANLD-----------SP-- 308 Query: 340 QDRSHMPYTDAVVHEVQRYIDLLPTSLPH-AVTCDIKFRNYLIPKGTTILISLTSVLHDN 398 DA V E+ RY+ ++ P+ A D++ +I KG T+ I L +V D Sbjct: 309 ---------DA-VEELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDP 358 Query: 399 KEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456 K F P++ LD K + F G C+G+ LA +E+ + T + F Sbjct: 359 KVFDEPDILQ----LDRVDARKHAA----FGGGIHQCLGQQLARVEMRIGFTRLFARF 408 >4OQS-A nrPDB Length = 433 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 52/178 (29%), Positives = 77/178 (43%), Gaps = 32/178 (17%) Query: 280 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339 ++ T E L N A+ L AG ETT+ L LL+HPE A + SP Sbjct: 223 TDLTDEELTNIALLLLVAGHETTANMLGLGTFALLQHPEQIAALD-----------SP-- 269 Query: 340 QDRSHMPYTDAVVHEVQRYIDLLPTSLPH-AVTCDIKFRNYLIPKGTTILISLTSVLHDN 398 DA V E+ RY+ ++ P+ A D++ +I KG T+ I L +V D Sbjct: 270 ---------DA-VEELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDP 319 Query: 399 KEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456 K F P++ LD K + F G C+G+ LA +E+ + T + F Sbjct: 320 KVFDEPDILQ----LDRVDARKHAA----FGGGIHQCLGQQLARVEMRIGFTRLFARF 369 >3EJB-B nrPDB Length = 404 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 60/236 (25%), Positives = 97/236 (41%), Gaps = 54/236 (22%) Query: 234 LKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVD 293 ++ +A+ K +++K K H + QD I L EK+K T E +T + Sbjct: 185 VQAMAYFKE-LIQKRKRHPQ-------QDMISMLLKGREKDK------LTEEEAASTCIL 230 Query: 294 LFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVH 353 L AG ETT + ++L LL+HPE K++E + +IG C++ S T V Sbjct: 231 LAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPD-LIGTAVEECLRYESPTQMTARVAS 289 Query: 354 EVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFD----- 408 E DI I +G + + L + D F NP++FD Sbjct: 290 E------------------DIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSP 331 Query: 409 -PHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVD 463 PH + F G +C+G +LA +E + + ++LQ +L D Sbjct: 332 NPH---------------LSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLAD 372 >6CR2-A nrPDB Length = 477 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 59/270 (21%), Positives = 117/270 (43%), Gaps = 34/270 (12%) Query: 218 NFSPI---IDYFPGTHNKLLKNVAFMK--SYILEKVKEHQESMDMNNPQDFIDCFLMKME 272 F+PI + + P HN+ ++ A K +E +K +++ + +D + + + Sbjct: 182 GFAPINFMLPWAPLPHNRK-RDAAQRKLTETYMEIIKARRQAGSKKDSEDMVWNLMSCVY 240 Query: 273 KEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIG 332 K P E + + + L AG ++S+T + +L L P++ ++ +E RV+G Sbjct: 241 KNGTPVPDE----EIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVLG 296 Query: 333 RNRSPCMQDR-SHMPYTDAVVHEVQRY---IDLLPTSLPHAVTCDIKFRNYLIPKGTTIL 388 + P D + V+ E R I + ++ + + D +Y+IP +L Sbjct: 297 SDLPPLTYDNLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGT--SYVIPTSHNVL 354 Query: 389 ISLTSVLHDNKEFPNPEMFDPHHFLDE-----GGNFKKSKY------------FMPFSAG 431 S + FPNP ++PH + DE + +K Y ++PF AG Sbjct: 355 SSPGVTARSEEHFPNPLEWNPHRW-DENIAASAEDDEKVDYGYGLVSKGTNSPYLPFGAG 413 Query: 432 KRICVGEALAGMELFLFLTSILQNFNLKSL 461 + C+GE A ++L +++ F ++L Sbjct: 414 RHRCIGEQFAYLQLGTITAVLVRLFRFRNL 443 >2W0A-A nrPDB Length = 455 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 42/188 (22%), Positives = 85/188 (45%), Gaps = 6/188 (3%) Query: 282 FTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQD 341 F+ + + + + AG T+S T + L+ L++H + A V +E++ + G RS Sbjct: 241 FSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHA 300 Query: 342 RSHMPYTDAVVHEVQRYIDLLP--TSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNK 399 +P + V+ E R L P L + + + + I +G + S + Sbjct: 301 LRQIPQLENVLKETLR---LHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPE 357 Query: 400 EFPNPEMFDPHHFLDEGGNFKKSKY-FMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458 +FP+P F P + +++ ++PF AG+ CVG A A M++ + +L+ + Sbjct: 358 DFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEF 417 Query: 459 KSLVDPKN 466 + P++ Sbjct: 418 EMAQPPES 425 >5VWS-A nrPDB Length = 393 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 54/232 (23%), Positives = 90/232 (38%), Gaps = 45/232 (19%) Query: 232 KLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTA 291 +L + VA + + + ++EH S +P+D + L++ E E +E + NTA Sbjct: 173 ELARTVAAAMTEMNDYLREHCRSR-RTHPRDDLLTRLVQAEVEG----KRLDLEEVVNTA 227 Query: 292 VDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIG------RNRSPCMQDRSHM 345 L AG TT+ + +L L HPE V+ + + R RSP +Q Sbjct: 228 SLLLLAGHLTTTVLIGNTMLCLWDHPEAEKAVRADPSLIPAALEESLRLRSPFLQ----- 282 Query: 346 PYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPE 405 T D+ IP ++ + S HD++ FP+PE Sbjct: 283 --------------------AGRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPE 322 Query: 406 MFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFN 457 FD H +++ + F G C+G L +E + L +L F Sbjct: 323 RFDLH---------RQTTGHIAFGHGVHFCLGAQLGRLEGRIALERLLGRFT 365 >2Y5N-A nrPDB Length = 417 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 71/324 (21%), Positives = 122/324 (37%), Gaps = 72/324 (22%) Query: 140 SIEDRVQEEARCLVEELRKTKASPCDPTFILGCA-PCNVICSIIF-----HKRFDYKDQQ 193 S+ R +E A LV+++ T P D + P VIC ++ H RF Sbjct: 129 SLRPRAREIAHELVDQMAAT-GQPADLVAMFARQLPVRVICELLGVPSADHDRFTRWSGA 187 Query: 194 FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQE 253 FL+ E E ++ + + A+M I + KE Sbjct: 188 FLSTAEVTAEEMQEAAE------------------------QAYAYMGDLIDRRRKE--- 220 Query: 254 SMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLL 313 P D + L++ +Q + + L + A+ L AG E+T+T + + LL Sbjct: 221 ------PTDDLVSALVQ----ARDQQDSLSEQELLDLAIGLLVAGYESTTTQIADFVYLL 270 Query: 314 LKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDL-LPTSLPHAVTC 372 + PE+ ++ + E + + V E+ R++ L + T+ P Sbjct: 271 MTRPELRRQLLDRPELI------------------PSAVEELTRWVPLGVGTAFPRYAVE 312 Query: 373 DIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGK 432 D+ R I G +L S + D +FP+ + D +D N + F G Sbjct: 313 DVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRID----VDRTPN-----QHLGFGHGV 363 Query: 433 RICVGEALAGMELFLFLTSILQNF 456 C+G LA +EL + L +LQ Sbjct: 364 HHCLGAPLARVELQVALEVLLQRL 387 >6FSH-A nrPDB Length = 398 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 53/232 (22%), Positives = 89/232 (38%), Gaps = 42/232 (18%) Query: 241 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 300 ++ + +K + +M +D D F+ + E + T E L V L AG + Sbjct: 183 RAALGDKFSRYLLAMIARERKDPGDGFIGSIVAEHGDT---ITDEELRGVCVQLMLAGDD 239 Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360 S + +L LL+HPE A ++ G ++S D V E+ RY+ Sbjct: 240 NVSGMIGLGVLALLRHPEQIAALR-------GDDQS-----------ADRAVDELIRYLT 281 Query: 361 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFD------PHHFLD 414 + P D+ + +I +G T+L SL D P+ + D PH Sbjct: 282 VPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTRTPVPH---- 337 Query: 415 EGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKN 466 + F G C+G AL ++L + T++ + F L DP Sbjct: 338 -----------VAFGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPAQ 378 >2VZM-A nrPDB Length = 436 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 61/258 (23%), Positives = 95/258 (36%), Gaps = 38/258 (14%) Query: 226 FPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIE 285 FP + +A M Y+ +D QD D L + + S T E Sbjct: 200 FPDDPAQAQTAMAEMSGYL-------SRLIDSKRGQDGED-LLSALVRTSDEDGSRLTSE 251 Query: 286 SLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHM 345 L A L AG ETT + + LL HP+ A + R+ M Sbjct: 252 ELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAAL------------------RADM 293 Query: 346 PYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPE 405 D V E+ RY + ++ + +IP G T+L+ L + FP+P Sbjct: 294 TLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPH 353 Query: 406 MFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF-NLKSLVDP 464 FD D G+ F G C+G LA +E + + ++L+ +L V P Sbjct: 354 RFDIRR--DTAGHLA-------FGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSP 404 Query: 465 KNLD--TTPVVNGFASVP 480 L P++ G ++P Sbjct: 405 GELVWYPNPMIRGLKALP 422 >4TX3-A nrPDB Length = 404 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 57/261 (21%), Positives = 96/261 (36%), Gaps = 54/261 (20%) Query: 212 WIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKM 271 ++Q+C+ +D + AF + + +E + D D F+ + Sbjct: 172 FLQLCHRH---LDASLSARKRAAAGEAFARYLVAMMARERK---------DPGDGFIGSI 219 Query: 272 EKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVI 331 E + T E L V L AG + S + +L LL+HPE A ++ Sbjct: 220 VAEHGDT---ITDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALR------- 269 Query: 332 GRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISL 391 G ++S D V E+ RY+ + P D+ + +I +G T+L SL Sbjct: 270 GDDQS-----------ADRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSL 318 Query: 392 TSVLHDNKEFPNPEMFD------PHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMEL 445 D P+ + D PH + F G C+G AL ++L Sbjct: 319 PMANRDRALLPDADRLDVTRTPVPH---------------VAFGHGIHHCLGAALTRLQL 363 Query: 446 FLFLTSILQNFNLKSLVDPKN 466 + T++ + F L DP Sbjct: 364 RIAYTALWRRFPALQLADPAQ 384 >3JUS-A nrPDB Length = 461 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 90/448 (20%), Positives = 161/448 (35%), Gaps = 55/448 (12%) Query: 34 TPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEE 93 +P+P +G+ + G I + L N + YGPVF+ K L G +A E+ Sbjct: 18 SPIPFLGHAIAFGKSPI-EFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNED 76 Query: 94 FSGRGIFPLAERANRGFGI-------VFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQ 146 + ++ G G+ VF KK + S + + +F IE + Sbjct: 77 LNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLK----SGLNIAHFKQHVSIIEKETK 132 Query: 147 EEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIK 206 E E K IL + C H + + +LNE + Sbjct: 133 EYFESWGESGEKNVFEALSELIILTASHC-------LHGK---------EIRSQLNEKVA 176 Query: 207 ILSSPWIQICNNFSPIIDYFPG-----THNKLLKNVAFMKSYILEKVKEHQESMDMNNPQ 261 L + + FS PG + + + +K + +++ ++S Q Sbjct: 177 QL---YADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQS------Q 227 Query: 262 DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTA 321 + ID L + + T + + + L AG T+STT + L + + Sbjct: 228 EKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQK 287 Query: 322 KVQEEIERVIGRNRSPCMQDR-SHMPYTDAVVHEVQR-----YIDLLPTSLPHAVTCDIK 375 K E + V G N P D+ + D + E R I + P V Sbjct: 288 KCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVA---- 343 Query: 376 FRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRIC 435 Y IP G + +S T + F+P +L + + ++PF AG+ C Sbjct: 344 --GYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRC 401 Query: 436 VGEALAGMELFLFLTSILQNFNLKSLVD 463 +GE A +++ +++L+ + L+D Sbjct: 402 IGENFAYVQIKTIWSTMLRLYEF-DLID 428 >6GMF-A nrPDB Length = 397 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 48/172 (27%), Positives = 69/172 (40%), Gaps = 31/172 (18%) Query: 286 SLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHM 345 S NT L AG ETT++ + AL+ L HPE A Q ++ V Sbjct: 225 SFANT---LLIAGNETTTSLIGNALVALTDHPEQLAAAQADLSLV--------------- 266 Query: 346 PYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPE 405 AVV EV RY +T D++ + IP + +L L S D FP+P+ Sbjct: 267 ---PAVVEEVLRYESPAQCIFRQTMT-DVEIGDERIPARSVVLPLLASANRDESRFPDPD 322 Query: 406 MFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFN 457 FD H + +K + F C+G LA +E + L +L Sbjct: 323 RFDIH---------RDTKGHLAFGLDIHFCIGAPLARLEAKVMLEVLLARLG 365 >3A1L-A nrPDB Length = 425 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 45/177 (25%), Positives = 76/177 (42%), Gaps = 28/177 (15%) Query: 280 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339 S +++ + T V L AG ETT+ L A+L L H +V +++ E Sbjct: 237 SPLSVDGIVGTCVHLLTAGHETTTNFLAKAVLTLRAHRDVLDELRTTPE----------- 285 Query: 340 QDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNK 399 T A V E+ RY D ++ DI+ ++ IP+G+ ++ L S D Sbjct: 286 -------STPAAVEELMRY-DPPVQAVTRWAYEDIRLGDHDIPRGSRVVALLGSANRDPA 337 Query: 400 EFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456 FP+P++ D H + ++ + F G C+G LA E + L ++L Sbjct: 338 RFPDPDVLDVH---------RAAERQVGFGLGIHYCLGATLARAEAEIGLRALLDGI 385 >5EX6-C nrPDB Length = 434 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 54/255 (21%), Positives = 95/255 (37%), Gaps = 42/255 (16%) Query: 212 WIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKM 271 ++Q+C+ +D + AF + + +E ++ D L+ M Sbjct: 202 FLQLCHRH---LDASLSGRRRAAAGEAFSRYLVTMVARERKDPGD----------GLIGM 248 Query: 272 EKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVI 331 +H T E L V + AG + S + +L LL++PE A + Sbjct: 249 VVAEHG--DTVTDEELRGVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAAL-------- 298 Query: 332 GRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISL 391 R +P + V E+ RY+ + P D + +I G T+L SL Sbjct: 299 ----------RGDVPAAERAVDELIRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSL 348 Query: 392 TSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTS 451 + D P+ + D +++ + F G C+G ALA +EL + T+ Sbjct: 349 PTANRDPALLPDADRLD---------VTREAVPHVAFGHGVHHCLGAALARLELRIAYTA 399 Query: 452 ILQNFNLKSLVDPKN 466 + + F L DP Sbjct: 400 LWRRFPDLRLADPDG 414 >1WIY-A nrPDB Length = 389 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 54/196 (27%), Positives = 83/196 (42%), Gaps = 31/196 (15%) Query: 276 HNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNR 335 H S E + AV L AG ET ++ L ++ LLL P+ +V E Sbjct: 200 HPPLSHLPRERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRVAE---------- 249 Query: 336 SPCMQDRSHMPYTDAVVHEVQRYIDLLPTS--LPHAVTCDIKFRNYLIPKGTTILIS--L 391 +A + Q + L P + L + + +P+GTT+++S + Sbjct: 250 -----------SEEAALAAFQEALRLYPPAWILTRRLERPLLLGEDRLPQGTTLVLSPYV 298 Query: 392 TSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTS 451 T L+ FP E F P FL E G +YF PF G+R+C+G A +E + L + Sbjct: 299 TQRLY----FPEGEAFQPERFLAERGT-PSGRYF-PFGLGQRLCLGRDFALLEGPIVLRA 352 Query: 452 ILQNFNLKSLVDPKNL 467 + F L L P+ L Sbjct: 353 FFRRFRLDPLPFPRVL 368 >1Z8P-A nrPDB Length = 404 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 46/197 (23%), Positives = 84/197 (42%), Gaps = 28/197 (14%) Query: 265 DCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQ 324 D L + + + + + + L + A+ L AG E++ + + LLL HP+ A V+ Sbjct: 209 DDLLSALIRVQDDDDGRLSADELTSIALVLLLAGFESSVSLIGIGTYLLLTHPDQLALVR 268 Query: 325 EEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKG 384 +D S +P V E+ RYI P + +++ IP+ Sbjct: 269 ---------------RDPSALPNA---VEEILRYI-APPETTTRFAAEEVEIGGVAIPQY 309 Query: 385 TTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGME 444 +T+L++ + D K+FP+P FD + ++ + F G C+G LA +E Sbjct: 310 STVLVANGAANRDPKQFPDPHRFD---------VTRDTRGHLSFGQGIHFCMGRPLAKLE 360 Query: 445 LFLFLTSILQNFNLKSL 461 + L ++ F SL Sbjct: 361 GEVALRALFGRFPALSL 377 >1CPT-A nrPDB Length = 428 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 48/189 (25%), Positives = 81/189 (42%), Gaps = 28/189 (14%) Query: 292 VDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAV 351 V + AG +TTS++ A++ L ++PE A + + P + R + Sbjct: 262 VAIATAGHDTTSSSSGGAIIGLSRNPEQLALAKSD----------PALIPR--------L 303 Query: 352 VHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHH 411 V E R+ + + + A+ D + R I +G I++S S D + F NP+ FD Sbjct: 304 VDEAVRWTAPVKSFMRTAL-ADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEFDITR 362 Query: 412 FLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTP 471 F + + F G +C+G+ LA +E+ +F +L L P L T Sbjct: 363 FPNR---------HLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLKSVELSGPPRLVATN 413 Query: 472 VVNGFASVP 480 V G +VP Sbjct: 414 FVGGPKNVP 422 >6M7L-A nrPDB Length = 404 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 46/196 (23%), Positives = 79/196 (40%), Gaps = 31/196 (15%) Query: 277 NQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRS 336 + ++ + E L + + E T + L LLLL+HPE A ++E E Sbjct: 224 DHGADISDEELAGLCAVVMNSSVEQTESCLAAGTLLLLEHPEQFALLRERPE-------- 275 Query: 337 PCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLH 396 + V E+ RY+ + P T D++ +I KG + SL + Sbjct: 276 ----------LGEQAVEEIVRYLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAA-- 323 Query: 397 DNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456 N+ P + FD +K + F G C+G LA MEL + T+++ F Sbjct: 324 -NRADPALDGFD---------ITRKESRHVAFGHGIHHCLGAPLARMELRIAFTTLVSRF 373 Query: 457 -NLKSLVDPKNLDTTP 471 +L++ V + + P Sbjct: 374 PSLRTAVPAEEIRFRP 389 >5LIV-A nrPDB Length = 450 Score = 51.6 bits (122), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 46/176 (26%), Positives = 73/176 (41%), Gaps = 31/176 (17%) Query: 283 TIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDR 342 TIE+ + L G ETTS + + LL HP+ A+V+ QD Sbjct: 265 TIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVR---------------QDP 309 Query: 343 SHMPYTDAVVHEVQRYIDLLPTSLP--HAVTCDIKFRNYLIPKGTTILISLTSVLHDNKE 400 S +P A + E R+ P+S V D++ + + GT + ++ + +D Sbjct: 310 SLLP---AAIEEGMRWC---PSSFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETA 363 Query: 401 FPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456 +P+PE++D N F G CVG LA ME + L ++L F Sbjct: 364 YPSPEVYDIDRKPLPAANV--------FGGGAHFCVGAPLARMEARVGLQALLARF 411 >5CJE-A nrPDB Length = 393 Score = 51.6 bits (122), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 48/216 (22%), Positives = 85/216 (39%), Gaps = 34/216 (15%) Query: 240 MKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGT 299 + +Y+ E + + + + P D + L++ E ++ + E L A L AG Sbjct: 183 LAAYLDELIDDKRSTA----PADDLLGDLIRTRAEDDDR---LSGEELRAMAFILLVAGH 235 Query: 300 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYI 359 ETT + + LL HP+ A + R+ M D V EV R+ Sbjct: 236 ETTVNLITNGVHTLLTHPDQLAAL------------------RADMTLLDGAVEEVLRFE 277 Query: 360 DLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNF 419 + T+ ++ I +G ++I L + D P+P +FD H Sbjct: 278 GPVETATYRYAAESMEIGGTAIAEGDPVMIGLDAAGRDPARHPDPHVFDIH--------- 328 Query: 420 KKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQN 455 + + + F G C+G LA +E + L S+L+ Sbjct: 329 RAPQGHLAFGHGIHYCLGAPLARLEARVALRSLLER 364 >5Y1I-A nrPDB Length = 403 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 63/300 (21%), Positives = 112/300 (37%), Gaps = 63/300 (21%) Query: 174 PCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKL 233 P VIC ++ Y+D++FL Q NN D G K Sbjct: 148 PVRVICEMLG---VPYEDREFL------------------QQNNNAMIYRDTAQGDAQKA 186 Query: 234 -LKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAV 292 + ++K + K+ + + D + +++E E T + + Sbjct: 187 AIAQAMYLKELVGTKLGDRGD--------DILSDLAVQVEA------GEITQDDAAGIGM 232 Query: 293 DLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVV 352 L GAG ETT+ + L LL++PE A+V++ + + N V Sbjct: 233 MLLGAGHETTANMIALGTLALLENPEQLAEVRDSDDPKVIVN----------------TV 276 Query: 353 HEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPN-PEMFDPHH 411 E+ RY+ + ++ DI+ +I G I+ L + D +P P+ D H Sbjct: 277 EELLRYLTIAQDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPDLYPEAPDRLDIHR 336 Query: 412 FLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTP 471 ++ + F G C+G LA +EL + +++L+ +L LD P Sbjct: 337 --------ANARRHLAFGYGVHQCLGATLARVELQIVYSTLLRRIPTLALA--GTLDEIP 386 >6F88-A nrPDB Length = 400 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 45/176 (25%), Positives = 73/176 (41%), Gaps = 31/176 (17%) Query: 283 TIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDR 342 TIE+ + L G ETTS + + LL HP+ A+V+ QD Sbjct: 215 TIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVR---------------QDP 259 Query: 343 SHMPYTDAVVHEVQRYIDLLPTSLP--HAVTCDIKFRNYLIPKGTTILISLTSVLHDNKE 400 S +P A + E R+ P++ V D++ + + GT + ++ + +D Sbjct: 260 SLLP---AAIEEGMRWC---PSNFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETA 313 Query: 401 FPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456 +P+PE++D N F G CVG LA ME + L ++L F Sbjct: 314 YPSPEVYDIDRKPLPAANV--------FGGGAHFCVGAPLARMEARVGLQALLARF 361 >3TKT-A nrPDB Length = 450 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 54/230 (23%), Positives = 94/230 (40%), Gaps = 45/230 (19%) Query: 267 FLMKMEKEKHNQPSEFTIESLENTAVD---------------LFGAGTETTSTTLRYALL 311 + + E+ P++ + N VD AG +TTS + A L Sbjct: 244 YFAGLAAERRRNPTDDVATVIANAVVDGEPMSDRDTAGYYIITASAGHDTTSASSAGAAL 303 Query: 312 LLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVT 371 L + P++ A+V+ DR+ +P +V E R+ + + A T Sbjct: 304 ALARDPDLFARVK---------------ADRNLLP---GIVEEAIRWTTPVQHFMRTAAT 345 Query: 372 CDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAG 431 D + I G ++++ + HD +FP P FDP + + + F AG Sbjct: 346 -DTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDP---------TRPANRHLAFGAG 395 Query: 432 KRICVGEALAGMELFLFLTSILQNFNLKSLV-DPKNLDTTPVVNGFASVP 480 C+G LA +E+ + L +L + L +PK +++T V GF S+P Sbjct: 396 SHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEPKRVNST-FVGGFKSLP 444 >3ABB-A nrPDB Length = 408 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 48/192 (25%), Positives = 79/192 (41%), Gaps = 30/192 (15%) Query: 291 AVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDA 350 A+ L AG ETT + L L++HPE +I+ ++ R P Sbjct: 237 ALVLLVAGHETTVNAIALGALTLIQHPE-------QIDVLL---RDPGA--------VSG 278 Query: 351 VVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPH 410 VV E+ R+ + + DI+ I G +L+S+T + D K + NP++FD Sbjct: 279 VVEELLRFTSV-SDHIVRMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDIFDAR 337 Query: 411 HFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTT 470 + +++ + F G C+G+ LA EL + L + L P LD Sbjct: 338 ---------RNARHHVGFGHGIHQCLGQNLARAELEIALGGLFARIPGLRLAVP--LDEV 386 Query: 471 PVVNGFASVPPF 482 P+ G + P Sbjct: 387 PIKAGHDAQGPI 398 >3SN5-A nrPDB Length = 491 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 53/222 (23%), Positives = 92/222 (41%), Gaps = 34/222 (15%) Query: 284 IESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVI---GRNRS---- 336 +E + V L+ + T T ++L ++++PE EE++R + G+ S Sbjct: 256 LEKAKTHLVVLWASQANTIPATF-WSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGN 314 Query: 337 -PCMQ--DRSHMPYTDAVVHEVQRY--IDLLPTSLPHAVTCDIKFRNYLIPKGTTILISL 391 C+ + + +P D+++ E R L + T ++ +Y I K I + Sbjct: 315 PICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYP 374 Query: 392 TSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS---------KYFMPFSAGKRICVGEALAG 442 + D + +P+P F +LDE G K + Y+MPF +G IC G A Sbjct: 375 QLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAI 434 Query: 443 MELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQ 484 E+ FL +L F L+ ++ G A PP Q Sbjct: 435 HEIKQFLILMLSYFELE------------LIEGQAKCPPLDQ 464 >5L1U-A nrPDB Length = 401 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 103/456 (22%), Positives = 167/456 (36%), Gaps = 96/456 (21%) Query: 47 IKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERA 106 I I+ + L K GP+ + + ++ Y+ V+ L D S P A+ A Sbjct: 17 IMGIAPQMLALQK-EGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQPSAKSA 75 Query: 107 NRGFGIVFSNGKKWKE------------IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVE 154 R F + + G + I RFS LR + K IE V E L++ Sbjct: 76 ARAFMVALAAGDDHETEPARHAQMRSLLIPRFSTRRLR---LMKTRIEHHVDE----LLD 128 Query: 155 ELRKTKASPCDPTFILGCA-PCNVICSII---FHKRFDYKDQQFLNLMEKLNENIKILSS 210 +L A P D +L P V+C ++ R + + NE+ Sbjct: 129 QL-AASAPPVDLHRVLSFRLPTMVVCDLLGVPLADRERFGQWARGTFDQSDNEHS----- 182 Query: 211 PWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMK 270 N F ++DY M + K E P D I L + Sbjct: 183 -----ANTFQQVVDY--------------MLELVARKRVE---------PGDDI---LSE 211 Query: 271 MEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERV 330 + EK S+ I L N AV LFG ETT + LLLL++P A++ E+ Sbjct: 212 LIAEKDGALSDADIAHLGN-AVLLFG--YETTIVRIDLGTLLLLRNPVQRAQLAED---- 264 Query: 331 IGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTS---LPHAVTCDIKFRNYLIPKGTTI 387 P + A V E+ R S +P DI +I G + Sbjct: 265 ------PGL--------APAAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAV 310 Query: 388 LISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFL 447 ++++ + +D++ FP+ +FD + + + F G R C+G LA +EL Sbjct: 311 MLAIGAANYDDRAFPDGGLFDLTRV--------RPRSHLAFGHGARHCIGRTLARIELTA 362 Query: 448 FLTSILQNF-NLKSLVDPKNL--DTTPVVNGFASVP 480 + + +L+ V ++L + GF +P Sbjct: 363 VFERLFRRLPDLRLAVPEESLRWQEHRITGGFDEIP 398 >2Z36-A nrPDB Length = 413 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 47/222 (21%), Positives = 87/222 (39%), Gaps = 36/222 (16%) Query: 235 KNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDL 294 + A +++YI + + + + P D D F ++ +++ Q L + A L Sbjct: 192 RAFAELRAYIDDLITRKE-----SEPGD--DLFSRQIARQR--QEGTLDHAGLVSLAFLL 242 Query: 295 FGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHE 354 AG ETT+ + ++ LL HPE V+ R T V E Sbjct: 243 LTAGHETTANMISLGVVGLLSHPEQLTVVKANPGR------------------TPMAVEE 284 Query: 355 VQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLD 414 + RY + T D++ I G +++S+ S D F +P + D Sbjct: 285 LLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVE---- 340 Query: 415 EGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456 + +++ + F G C+G+ LA MEL + ++ + Sbjct: 341 -----RGARHHLAFGFGPHQCLGQNLARMELQIVFDTLFRRI 377 >4GGV-A nrPDB Length = 418 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 47/176 (26%), Positives = 75/176 (42%), Gaps = 30/176 (17%) Query: 282 FTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQD 341 T + N A L G TT+ TL +L L PEV AKV+ D Sbjct: 242 LTDNEIVNVANILLVTGHITTTMTLGNTVLCLDADPEVAAKVR---------------AD 286 Query: 342 RSHMPYTDAVVHEVQRYIDLLPTS-LPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKE 400 RS +P + E R L P++ L + +++ +IPK +++ L + D ++ Sbjct: 287 RSLVP---GAIEEALRV--LSPSAALARGTSREVEVAGTVIPKDQIVMLWLGAGNRDPRQ 341 Query: 401 FPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456 F +PE++DP D +F F G C+G LA +E + L ++ F Sbjct: 342 FTDPEVYDPTR--DPNPHFG-------FGRGIHFCLGAPLARLEGRVALNALFDRF 388 >6GK6-A nrPDB Length = 411 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 51/223 (22%), Positives = 80/223 (35%), Gaps = 35/223 (15%) Query: 261 QDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVT 320 D I L+ E+E P+E L + L AG ETT + +LLLL HP Sbjct: 212 DDLISGLLLAEEQEHKLSPAE-----LSSMVFLLLVAGHETTVHLIASGMLLLLSHPAER 266 Query: 321 AKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYL 380 ++ E+ P + + V E R S DI+ Sbjct: 267 RRLDED----------PGL--------VGSAVEEALRCEGPAELSTIRWSLEDIELFGAR 308 Query: 381 IPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEAL 440 +P G + L + D + FP+P+ FD + + F G C+G L Sbjct: 309 VPAGEGVAAGLLAANRDPQHFPDPDRFD---------IGRSPNRHIGFGGGIHFCLGAML 359 Query: 441 AGMELFLFLTSILQNFNLKSLVDPKN---LDTTPVVNGFASVP 480 A +E + +++L+ L P + G A+VP Sbjct: 360 ARIEAAIAFSTLLRRLPRIELATSTRDIVWSEWPTIRGPAAVP 402 >2IJ7-A nrPDB Length = 396 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 43/177 (24%), Positives = 69/177 (38%), Gaps = 26/177 (14%) Query: 280 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339 S + E V FGAG +T + L AL+ L++ P++ + E+ E + Sbjct: 216 SHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELI--------- 266 Query: 340 QDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNK 399 A V E+ R LP T DI+ + L+ KG +L+ L D + Sbjct: 267 ---------PAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPE 317 Query: 400 EFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456 FPNP + LD + F G+ C G AL + + ++L+ Sbjct: 318 HFPNPGSIE----LDR----PNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKM 366 >4WPZ-A nrPDB Length = 397 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 52/233 (22%), Positives = 100/233 (42%), Gaps = 37/233 (15%) Query: 254 SMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLL 313 ++ NP D + L+ + + S T + ++ + AG ETT+ + L+ L Sbjct: 193 AVKRENPADDLISELIAI----SDGDSTLTEREIIALSIGILSAGHETTANQISMFLVTL 248 Query: 314 LKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTS--LPHAVT 371 L +PE K+++ +R +P V E+ R++ L T +P T Sbjct: 249 LHNPEELDKLRD---------------NREAIPKA---VDELLRFVPLTTTGGIIPRLTT 290 Query: 372 CDIKFR-NYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSA 430 +++ ++P G +L ++ + D PE+F+ L+ +++ + F A Sbjct: 291 AEVELSGGQVLPAGAVVLPAVATANRD------PEVFEDGERLN---VTRENNPHLAFGA 341 Query: 431 GKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKN---LDTTPVVNGFASVP 480 G C+G LA +EL L +IL L P++ L + ++ G S+P Sbjct: 342 GIHHCLGAQLARIELQEALGAILDRMPQVRLAVPESELRLKSASIIRGLESLP 394 >6A7I-A nrPDB Length = 411 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 52/219 (23%), Positives = 83/219 (37%), Gaps = 34/219 (15%) Query: 258 NNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 317 N D + E H T E + NT + AG ETT + + + L HP Sbjct: 206 NPGDDLTSALIAASENGDH-----LTDEEIVNTLQLIIAAGHETTISLIVNVVEALQTHP 260 Query: 318 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFR 377 E KV + IG D V+ E R+ L T DI+ Sbjct: 261 EQRKKV---LNGEIG---------------WDGVIEETLRWNTPTSHVLIRFATEDIEVG 302 Query: 378 NYLIPKGTTILISLTSVLHDNKEF-PNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICV 436 + ++PKG ++IS ++ D +++ P FD + + F G +C Sbjct: 303 DKILPKGEGLIISFGALGRDEEQYGPTAGEFD---------ATRTPNRHIAFGHGPHVCP 353 Query: 437 GEALAGMELFLFLTSILQNF-NLKSLVDPKNLDTTPVVN 474 G AL+ +E + L ++ + F L V +L P+V Sbjct: 354 GAALSRLEAGIALPALYERFPELDLAVPASDLRNKPIVT 392 >4RM4-A nrPDB Length = 396 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 53/211 (25%), Positives = 80/211 (37%), Gaps = 43/211 (20%) Query: 261 QDFIDCFLMKMEKEKHNQPSEFTIESL---ENTAVDLFG------------AGTETTSTT 305 ++ + F + +EK N+P + I L E T L G AG ETT+ Sbjct: 188 EEELAAFFAGIIEEKRNKPEQDIISILVEAEETGEKLSGEELIPFCTLLLVAGNETTTNL 247 Query: 306 LRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTS 365 + A+ +L+ P V EE+ RSH V E R+ P Sbjct: 248 ISNAMYSILETP----GVYEEL--------------RSHPELMPQAVEEALRFRAPAPV- 288 Query: 366 LPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYF 425 L D + +LI +G +L + S D +F P MFD + Sbjct: 289 LRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIR---------RHPNPH 339 Query: 426 MPFSAGKRICVGEALAGMELFLFLTSILQNF 456 + F G C+G LA +E + LTS++ F Sbjct: 340 IAFGHGIHFCLGAPLARLEANIALTSLISAF 370 >2RFC-A nrPDB Length = 343 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 41/157 (26%), Positives = 65/157 (41%), Gaps = 15/157 (9%) Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360 T ++Y +LL++ E T + + RVI N P + D + + V E RY Sbjct: 174 TMDEKIKYIMLLIIGGNETTTNLIGNMIRVIDEN--PDIIDDA-LKNRSGFVEETLRYYS 230 Query: 361 LLPTSLPHAVTC-DIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNF 419 + LPH D N I KG +++ L S D F P++F Sbjct: 231 PIQF-LPHRFAAEDSYINNKKIKKGDQVIVYLGSANRDETFFDEPDLF----------KI 279 Query: 420 KKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456 + + + F G +C+G LA +E + L IL +F Sbjct: 280 GRREMHLAFGIGIHMCLGAPLARLEASIALNDILNHF 316 >1Q5D-A nrPDB Length = 419 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 42/192 (21%), Positives = 78/192 (40%), Gaps = 29/192 (15%) Query: 265 DCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQ 324 D M ++ E S + + L + AGT+TT + +A+L LL+ PE V+ Sbjct: 224 DVLTMLLQAEADG--SRLSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVK 281 Query: 325 EEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKG 384 E P + + + EV R+ ++L D+++ I KG Sbjct: 282 AE----------PGLMRNA--------LDEVLRFDNILRIGTVRFARQDLEYCGASIKKG 323 Query: 385 TTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGME 444 + + + S L D F P++FD + + + + G +C G +LA +E Sbjct: 324 EMVFLLIPSALRDGTVFSRPDVFDVR---------RDTSASLAYGRGPHVCPGVSLARLE 374 Query: 445 LFLFLTSILQNF 456 + + +I + F Sbjct: 375 AEIAVGTIFRRF 386 >5YSW-A nrPDB Length = 441 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 43/188 (22%), Positives = 86/188 (45%), Gaps = 31/188 (16%) Query: 282 FTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQD 341 T + L N A L AG +TT++ L + +LL+ P A ++++ R+ Sbjct: 262 LTDDELINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDDPSRI----------- 310 Query: 342 RSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEF 401 DAV E+ RY+ ++ + D++F IP G+T+++S+ + D + + Sbjct: 311 ------ADAV-EELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHW 363 Query: 402 PNPEMFDPHHFLDEGGNFKKSKY-FMPFSAGKRICVGEALAGMELFLFLTSILQNF-NLK 459 P+P++ + + + + F G C+G+ LA ME+ +L+ N++ Sbjct: 364 PDPDL-----------DLTRPRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVR 412 Query: 460 SLVDPKNL 467 V P+ + Sbjct: 413 LAVPPEEV 420 >3P3Z-A nrPDB Length = 416 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 37/149 (24%), Positives = 55/149 (36%), Gaps = 26/149 (17%) Query: 297 AGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQ 356 AG ETT+ L A+ +HP+ K++E E V EV Sbjct: 253 AGYETTNHQLALAMYDFAQHPDQWMKIKENPE------------------LAPQAVEEVL 294 Query: 357 RYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEG 416 R+ LP + D + IP GT + + D + F + + FD Sbjct: 295 RWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFADADRFDI------- 347 Query: 417 GNFKKSKYFMPFSAGKRICVGEALAGMEL 445 K+ + F G C+G ALA +EL Sbjct: 348 -TVKREAPSIAFGGGPHFCLGTALARLEL 375 >4UBS-A nrPDB Length = 393 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 53/254 (20%), Positives = 101/254 (39%), Gaps = 50/254 (19%) Query: 224 DYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEK-------- 275 D+F +LL+ + +V++ + +D D++ + + KE Sbjct: 159 DFFESQSRRLLRGPG------IAEVQDARAQLD-----DYLYALIDRKRKEPGDGLLDDL 207 Query: 276 -HNQPSEFTIESLE--NTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIG 332 Q + T++ E + A L AG ETT+ + LL+HPE A+++ E Sbjct: 208 IQEQLNRGTVDRAELVSLATLLLIAGHETTANMISLGTFTLLRHPEQLAELRAE------ 261 Query: 333 RNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLT 392 P + MP A V E+ R++ + L T DI+ I ++ + + Sbjct: 262 ----PGL-----MP---AAVEELLRFLSIA-DGLLRVATEDIEVAGTTIRADEGVVFATS 308 Query: 393 SVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSI 452 + D F P+ D H + +++ + F G C+G+ LA E+ + L ++ Sbjct: 309 VINRDAAGFAEPDALDWH---------RSARHHVAFGFGIHQCLGQNLARAEMEIALGTL 359 Query: 453 LQNFNLKSLVDPKN 466 + L P + Sbjct: 360 FERLPGLRLAAPAD 373 >1LG9-A nrPDB Length = 398 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 45/193 (23%), Positives = 71/193 (36%), Gaps = 39/193 (20%) Query: 280 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339 + T E L V + AG + S + +L +L+HPE +I+ G +S Sbjct: 219 DDATDEELRGFCVQVMLAGDDNISGMIGLGVLAMLRHPE-------QIDAFRGDEQS--- 268 Query: 340 QDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNK 399 V E+ RY+ + + P D+ I KG +++ SL + D Sbjct: 269 --------AQRAVDELIRYLTVPYSPTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPA 320 Query: 400 EFPNPEMFD------PHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSIL 453 P+ + D PH + F G C+G ALA +EL T + Sbjct: 321 LAPDVDRLDVTREPIPH---------------VAFGHGVHHCLGAALARLELRTVFTELW 365 Query: 454 QNFNLKSLVDPKN 466 + F L DP Sbjct: 366 RRFPALRLADPAQ 378 >5YHJ-A nrPDB Length = 413 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 29/92 (31%), Positives = 42/92 (45%), Gaps = 10/92 (10%) Query: 352 VHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHH 411 V EV+R+ P + V D ++ Y P+GT L+ L HD + P+ FDP Sbjct: 276 VQEVRRFYPFFPVAAAR-VKTDFEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSR 334 Query: 412 FLDEGGNFKKSKY-FMPFSAGK----RICVGE 438 F D +K+S + F+P G C GE Sbjct: 335 FKD----WKESPFNFIPQGGGDVDFGHRCAGE 362 >4MM0-A nrPDB Length = 399 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 72/322 (22%), Positives = 124/322 (38%), Gaps = 67/322 (20%) Query: 186 RFDYKDQQFLNLMEKLNENIKILSS-----PWIQICNNFS-PIIDY--FPGTHNKLLKNV 237 R + + L+ MEK I+ S P IC P++D F G + ++ Sbjct: 115 RLEEIAEGLLDEMEKKGAPADIVESLAVPFPITVICELLGVPMVDVARFRGWADTMVS-- 172 Query: 238 AFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVD---- 293 + Y +E D +D ++ +L + K P + +L TA + Sbjct: 173 --LTGYSME---------DWTAARDALESYLDGLVAAKRENPGSDLLSALVATAAEDNEL 221 Query: 294 -----------LFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDR 342 L AG E S L ++L LL+ P+ A+++ R P + Sbjct: 222 TDHDVRSLSLILLLAGYEPASNQLGSSVLTLLRFPDRLAELR----------RDPGL--- 268 Query: 343 SHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFP 402 +P + V E+ RY +L D+ + IP + +L S + D + F Sbjct: 269 --LP---SAVEELMRYAPAGDGALFRVTLEDVTIGDTHIPANSAVLASTQAANWDPRRFD 323 Query: 403 NPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF-NLKSL 461 +P LD N + G C+G ALA +EL + + ++L+ F L Sbjct: 324 DPTGLR----LDRPDNQHTA-----LGHGIHFCLGAALARVELQVAIGALLRRFPRLALA 374 Query: 462 VDPKNLD-TTP--VVNGFASVP 480 D L ++P +++GFA +P Sbjct: 375 TDESGLRWSSPGSMLSGFAEIP 396 >6A7J-A nrPDB Length = 411 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 50/224 (22%), Positives = 83/224 (37%), Gaps = 34/224 (15%) Query: 253 ESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLL 312 E N D + E H T E + NT + AG ETT + + + Sbjct: 201 EEKKANPGDDLTSALIAASEDGDH-----LTDEEILNTLQLIIAAGHETTISLIVNVVEA 255 Query: 313 LLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTC 372 L HPE KV +P+ + V+ E R+ L T Sbjct: 256 LAIHPEQRKKVLS-----------------GEIPW-EGVIEETLRWNTPTSHVLIRFATE 297 Query: 373 DIKFRNYLIPKGTTILISLTSVLHDNKEF-PNPEMFDPHHFLDEGGNFKKSKYFMPFSAG 431 DI+ + ++PKG +++S ++ D +++ P FD + + F G Sbjct: 298 DIEVGDKVLPKGEGLVVSFGALGRDEEQYGPTAGDFD---------ATRTPNRHIAFGHG 348 Query: 432 KRICVGEALAGMELFLFLTSILQNF-NLKSLVDPKNLDTTPVVN 474 +C G AL+ +E + L ++ + F L V L P+V Sbjct: 349 PHVCPGAALSRLEAGIALPALYERFPELDLAVPAAELRNKPIVT 392 >3MGX-A nrPDB Length = 415 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 35/132 (26%), Positives = 53/132 (40%), Gaps = 10/132 (7%) Query: 349 DAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFD 408 D VV EV R+ L T D+ +P GT ++ L + D EF +P+ F Sbjct: 288 DTVVEEVLRWTSPAMHVL-RVTTADVTINGRDLPSGTPVVAWLPAANRDPAEFDDPDTFL 346 Query: 409 PHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLD 468 P +K + F G C+G ALA +EL + L + + + L Sbjct: 347 P---------GRKPNRHITFGHGMHHCLGSALARIELSVVLRVLAERVSRVDLEREPAWL 397 Query: 469 TTPVVNGFASVP 480 VV G+ +P Sbjct: 398 RAIVVQGYRELP 409 >5HH3-A nrPDB Length = 397 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 46/191 (24%), Positives = 72/191 (37%), Gaps = 40/191 (20%) Query: 280 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339 E T L A + GAG + + L L+ PE A ++E+ + V P Sbjct: 221 DEITDAELTGVAAFVMGAGADQVARFLAAGAWLMADDPEQFALLREKPDTV------PDW 274 Query: 340 QDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNK 399 D EV RY+ + P T D++ ++LI G T+ SL + + + Sbjct: 275 LD------------EVIRYLTTDEKTHPRVATDDVRIGDHLIKAGDTVTCSLLAA--NRR 320 Query: 400 EFPNPE-MFD-----PHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSIL 453 FP PE FD P H + F G C+G +LA + + ++ Sbjct: 321 NFPRPEDRFDITRVRPEH--------------LAFGHGIHHCLGRSLAELVFRTAIPALA 366 Query: 454 QNFNLKSLVDP 464 F L +P Sbjct: 367 HRFPTLRLAEP 377 >6F0B-A nrPDB Length = 395 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 44/200 (22%), Positives = 79/200 (39%), Gaps = 27/200 (13%) Query: 257 MNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKH 316 + +P + + L++ Q + T + L G +TT++T+ +L+ Sbjct: 193 VQDPSELPEDSLIRRLVTGPYQEKQLTFHETIGVILMLIVGGYDTTASTISLSLVSYALQ 252 Query: 317 PEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKF 376 PE + V E ER+ P + V E+ RY + L T D++ Sbjct: 253 PEKFSVVHEHPERI------PLL------------VEELLRYHTVSQLGLGRIATEDVEV 294 Query: 377 RNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICV 436 + G ++ +L D FPNP+ D D + S + F G CV Sbjct: 295 GGVTVRAGQMVVAALPLANRDESVFPNPDELD----FD-----RPSVPHVGFGYGPHQCV 345 Query: 437 GEALAGMELFLFLTSILQNF 456 G+ALA +EL + ++++ Sbjct: 346 GQALARVELQEAIPAVIRRL 365 >3R9C-A nrPDB Length = 418 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 50/226 (22%), Positives = 88/226 (38%), Gaps = 37/226 (16%) Query: 231 NKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENT 290 ++ +K +++ Y+ + E + + P + + L+ +E E +Q +E I + N Sbjct: 199 DEQMKAGMWLRDYLRALIDERRRT-----PGEDLMSGLVAVE-ESGDQLTEDEIIATCNL 252 Query: 291 AVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDA 350 L AG ETT + A L +L+ P A + + R A Sbjct: 253 ---LLIAGHETTVNLIANAALAMLRTPGQWAALAADGSRA------------------SA 291 Query: 351 VVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPH 410 V+ E RY D + D+ + +PKG T+L+ L + D P+ FDP Sbjct: 292 VIEETMRY-DPPVQLVSRYAGDDLTIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDPD 350 Query: 411 HFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456 + + F G C+G LA +E + L ++ F Sbjct: 351 ---------RAQIRHLGFGKGAHFCLGAPLARLEATVALPALAARF 387 >5M0P-A nrPDB Length = 428 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 23/81 (28%), Positives = 35/81 (43%), Gaps = 3/81 (3%) Query: 334 NRSPCMQDR--SHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISL 391 N +P +++ S Y EV+RY +P LP DI F+ IP G + + + Sbjct: 268 NENPITREKIKSEPDYAYKFAQEVRRYYPFVPF-LPGKAKVDIDFQGVTIPAGVGLALDV 326 Query: 392 TSVLHDNKEFPNPEMFDPHHF 412 HD + +P F P F Sbjct: 327 YGTTHDESLWDDPNEFRPERF 347 >4YZR-A nrPDB Length = 405 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 45/191 (23%), Positives = 74/191 (38%), Gaps = 32/191 (16%) Query: 294 LFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVH 353 L AG ETT L L LL+H + K++++ E + V Sbjct: 238 LVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIA------------------TAVE 279 Query: 354 EVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFL 413 E+ RY + D ++ + I +G I I + S D F NPE+ Sbjct: 280 ELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEIL------ 333 Query: 414 DEGGNFKKS-KYFMPFSAGKRICVGEALAGMELFLFLTSILQNF-NLKSLVDPKNLDTTP 471 N +S + F G C+G LA +E + ++L+ F +++ V P ++ Sbjct: 334 ----NINRSPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAPDDIQWRK 389 Query: 472 VV--NGFASVP 480 V G S+P Sbjct: 390 NVFLRGLESLP 400 >2IAG-A nrPDB Length = 482 Score = 41.6 bits (96), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 44/172 (25%), Positives = 75/172 (43%), Gaps = 32/172 (18%) Query: 314 LKHPEVTAKVQEEIERVIGRNRSPCMQDRS-------HMPYTDAVVHEVQRYIDLLPTSL 366 LK+PE A V+ E+E ++ + P Q + P D+V+ E R T+ Sbjct: 278 LKNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-----TAA 332 Query: 367 P---HAVTCDIKF-----RNYLIPKGTTILI-SLTSVLHDNKEFPNPEMFDPHHFLDEGG 417 P V D+ R + + +G +L+ S D + + +PE+F + FL+ G Sbjct: 333 PFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDG 392 Query: 418 NFKKS---------KYFMPFSAGKRICVGEALA--GMELFLFLTSILQNFNL 458 + KK Y MP+ AG C+G + A ++ F+FL + + L Sbjct: 393 SEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLEL 444 >6FYJ-A nrPDB Length = 421 Score = 41.6 bits (96), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 29/100 (29%), Positives = 43/100 (43%), Gaps = 10/100 (10%) Query: 347 YTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEM 406 Y+ V EV+R+ P + V D ++ Y +GT L+ L HD + + NP++ Sbjct: 279 YSQMFVQEVRRFYPFFPFVVA-LVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDV 337 Query: 407 FDPHHFLD-EGGNFKKSKYFMPFSAGKRI----CVGEALA 441 F P F EG F F+P G C GE + Sbjct: 338 FSPDRFAKWEGSPFS----FIPQGGGDYFMGHRCAGEWVT 373 >5EX8-A nrPDB Length = 424 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 41/184 (22%), Positives = 70/184 (38%), Gaps = 28/184 (15%) Query: 283 TIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDR 342 T L A + GA + + L L+++ P A ++E+ E V P D Sbjct: 251 TDAELTGVAAFVMGAAADQVARLLAAGAWLMVEQPAQFALLREKPETV------PEWLD- 303 Query: 343 SHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFP 402 E RY+ + P T D++ N L+ G T+ SL + N +P Sbjct: 304 -----------ETMRYLTTDEKTHPRVATQDVRIGNQLVKAGDTVTCSLLAANRPN--YP 350 Query: 403 NPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLV 462 + E DE ++ + F G C+G A+A + + + ++ F L Sbjct: 351 SAE--------DEFDITREKAEHLAFGHGIHHCLGRAMAELMFKVSIPALAHRFPTLRLA 402 Query: 463 DPKN 466 DP+ Sbjct: 403 DPQR 406 >3WVS-A nrPDB Length = 401 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 45/208 (21%), Positives = 85/208 (40%), Gaps = 28/208 (13%) Query: 274 EKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGR 333 E + + T + L + + L AG ETT++ + + LL P+ ++ ++ E + Sbjct: 218 EARDVQDKLTEQELLDHCIGLLIAGHETTASQIPSFVYALLDQPQHWKRLLDDPELI--- 274 Query: 334 NRSPCMQDRSHMPYTDAVVHEVQRYIDLLP-TSLPHAVTCDIKFRNYLIPKGTTILISLT 392 + V E+ R++ L ++ P DI+ L+ G +L++L Sbjct: 275 ---------------PSAVEELFRFVPLGSGSAAPRYAREDIEVGGTLVRAGEPVLVALG 319 Query: 393 SVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSI 452 + D F +PE LD + S + + F G C+G LA +EL L ++ Sbjct: 320 AANRDGLRFEDPEEIK----LD-----RPSNHHIGFGHGIHHCLGAPLARLELQEALRAL 370 Query: 453 LQNFNLKSLVDPKNLDTTPVVNGFASVP 480 L+ + + +V G S+P Sbjct: 371 LERLPTLKVAGDIAWKSEMMVRGPRSMP 398 >5IT1-A nrPDB Length = 399 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 42/178 (23%), Positives = 67/178 (37%), Gaps = 27/178 (15%) Query: 287 LENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMP 346 L N A L A +TT+ + LLL P+ A +Q++ +IG Sbjct: 227 LMNAAGTLLIAAHDTTACMIGLGTALLLDRPDQLALLQKD-PSLIGN------------- 272 Query: 347 YTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEM 406 V E+ RY+ + T D + I KG ++ L S D +PE Sbjct: 273 ----AVEELLRYLTIGQFGAERVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPER 328 Query: 407 FDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDP 464 FD ++ + F G C+G+ LA +EL + ++ + F L P Sbjct: 329 FD---------ITRRPAPHLAFGFGAHQCIGQQLARIELQIVFGTLFRRFPTLRLAKP 377 >1ODO-A nrPDB Length = 408 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 58/229 (25%), Positives = 89/229 (38%), Gaps = 38/229 (16%) Query: 259 NPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPE 318 P D + L+ ++ + E L +T + + AG ETT + A+ LL P+ Sbjct: 205 TPGDDMTSLLIAA-RDDEGDGDRLSPEELRDTLLLMISAGYETTVNVIDQAVHTLLTRPD 263 Query: 319 VTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRY---IDLLPTSLPHAVTCDIK 375 A V+ + + + D VV E R+ + LP L +AVT DI Sbjct: 264 QLALVR-----------------KGEVTWAD-VVEETLRHEPAVKHLP--LRYAVT-DIA 302 Query: 376 FRN-YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRI 434 + I +G IL S + + + FD + K + F G Sbjct: 303 LPDGRTIARGEPILASYAAANRHPDWHEDADTFD---------ATRTVKEHLAFGHGVHF 353 Query: 435 CVGEALAGMELFLFLTSILQNFNLKSLVDP-KNLDTTP--VVNGFASVP 480 C+G LA ME+ L L S+ F L DP + L P + NG +P Sbjct: 354 CLGAPLARMEVTLALESLFGRFPDLRLADPAEELPPVPSLISNGHQRLP 402 >5XW2-A nrPDB Length = 419 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 48/213 (22%), Positives = 82/213 (38%), Gaps = 33/213 (15%) Query: 244 ILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTS 303 +LE ++EH D + + E T + N A L AG TT+ Sbjct: 208 MLEYLREHAAECRRRPRGDLMGKLI-----EAEVDGRRLTDNHIVNFAKMLLIAGYLTTT 262 Query: 304 TTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP 363 + +L L +PE A+V+ DRS +P ++ E R++ + Sbjct: 263 MLIGNTVLCLDSYPEQAARVR---------------ADRSLIP---GLLEESMRFLSPVA 304 Query: 364 TSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSK 423 + A T D++ + +++ + D ++F PE+FD + G N Sbjct: 305 ATY-RATTRDVEVAGQRLSADQMVMVWFGAANRDARQFAEPELFD----MTRGPN----- 354 Query: 424 YFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456 + F G C+G LA ME + L +L F Sbjct: 355 PHLGFGRGIHFCLGGPLARMEGRVALDHLLDRF 387 >5HIW-A nrPDB Length = 398 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 22/76 (28%), Positives = 37/76 (48%), Gaps = 9/76 (11%) Query: 381 IPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEAL 440 + GT + +SL + +D + +P PE FD H ++ + F G CVG L Sbjct: 293 LAAGTILYLSLIARHYDEEIYPRPETFDIH---------RRPVGMLNFGGGLHYCVGAPL 343 Query: 441 AGMELFLFLTSILQNF 456 A ME + ++ +L+ F Sbjct: 344 ARMEARVGVSLLLERF 359 >5OFQ-A nrPDB Length = 409 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 57/262 (21%), Positives = 97/262 (37%), Gaps = 40/262 (15%) Query: 226 FPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIE 285 F K + V F++ Y E + E Q+ N +D I L E T E Sbjct: 179 FAKMMQKRNEGVIFLQGYFKEIIAERQQ----NKQEDLISLLL-----EAEIDGEHLTEE 229 Query: 286 SLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHM 345 + + L AG ETT+ + + + + VQ E+ R D S + Sbjct: 230 EVLGFCILLLVAGNETTTNLITNGVRYMTE----DVDVQNEVRR-----------DISLV 274 Query: 346 PYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPE 405 P +V E RY + ++ D++ I +G ++ S D+ +F P+ Sbjct: 275 P---NLVEETLRYYPPI-QAIGRIAAEDVELGECKIKRGQQVISWAASANRDSAKFEWPD 330 Query: 406 MFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPK 465 F H +K+ + F G C+G LA ME + T +L+ + + Sbjct: 331 TFVVH---------RKTNPHVSFGFGIHFCLGAPLARMEGKIAFTKLLEKGGFSKV---Q 378 Query: 466 NLDTTPVVNGFASVPPFYQLCF 487 N P+ + F Y++ F Sbjct: 379 NQSLKPIDSPFVFGVKKYEIAF 400 >4YT3-A nrPDB Length = 410 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 48/199 (24%), Positives = 84/199 (42%), Gaps = 32/199 (16%) Query: 259 NPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALL-LLLKHP 317 NP D I L+K E + FT + + T + + GAG ETTS L + LL Sbjct: 209 NPADDIISDLLKSEVDGEM----FTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYDDK 264 Query: 318 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFR 377 EV ++ E ++ ++ + ++ R ++ D V E DLL L Sbjct: 265 EVYQELHENLD-LVPQAVEEMLRFRFNLIKLDRTVKEDN---DLLGVEL----------- 309 Query: 378 NYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVG 437 +G ++++ +++ D + F +P + H +K + F G C+G Sbjct: 310 ----KEGDSVVVWMSAANMDEEMFEDPFTLNIHR--------PNNKKHLTFGNGPHFCLG 357 Query: 438 EALAGMELFLFLTSILQNF 456 LA +E + LT+ L+ F Sbjct: 358 APLARLEAKIALTAFLKKF 376 >3A50-A nrPDB Length = 411 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 86/401 (21%), Positives = 140/401 (34%), Gaps = 89/401 (22%) Query: 59 KVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFG----IVF 114 + PV L P+ +L Y V+EA +D R P +RA+ ++ Sbjct: 30 RAEDPVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHRLPEDQRADMPATPTPMMIL 89 Query: 115 SNGKKWKEIRRFSLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPCD-PTFILG- 171 + +R+ + R+F + + +E R+ E A L+ L P D P ++ Sbjct: 90 MDPPDHTRLRK---LVGRSFTVRRMNELEPRITEIADGLLAGL------PTDGPVDLMRE 140 Query: 172 ---CAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPG 228 P VIC ++ D D S W + + SP D Sbjct: 141 YAFQIPVQVICELLGLPAEDRDD-----------------FSAWSSVLVDDSPADD---- 179 Query: 229 THNKLLKNVAFMK-----SYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFT 283 KN A K S +LE+ + P D + L+ + ++ S+ Sbjct: 180 ------KNAAMGKLHGYLSDLLERKR--------TEPDDALLSSLLAVSDMDGDRLSQ-- 223 Query: 284 IESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRS 343 E L A+ L AG ETT + +L LL HP+ + E+ P + Sbjct: 224 -EELVAMAMLLLIAGHETTVNLIGNGVLALLTHPDQRKLLAED----------PSL---- 268 Query: 344 HMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPN 403 + V E R+ + + D+ + IP G +++ L + D P Sbjct: 269 ----ISSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPE 324 Query: 404 PEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGME 444 P+ D GG F F G C+G LA +E Sbjct: 325 PDRLDITRDA-SGGVF--------FGHGIHFCLGAQLARLE 356 >6GII-A nrPDB Length = 479 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 22/83 (26%), Positives = 38/83 (45%), Gaps = 8/83 (9%) Query: 370 VTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFS 429 T +++ +P G IL+ + S HD+ F +PE FD G S++ + F Sbjct: 362 TTREVEVEGVRLPVGANILMVVASANHDSAHFDDPEFFDI-------GRSNASEH-LNFG 413 Query: 430 AGKRICVGEALAGMELFLFLTSI 452 G C+G L ME+ + + + Sbjct: 414 YGAHQCLGRNLGRMEMQIMIEEL 436 >3AWQ-A nrPDB Length = 415 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 17/66 (25%), Positives = 31/66 (46%), Gaps = 1/66 (1%) Query: 347 YTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEM 406 Y + V EV+R+ P + A + D ++ P+G +++ L HD + +P+ Sbjct: 273 YAELFVQEVRRFYPFFPAVVARA-SQDFEWEGMAFPEGRQVVLDLYGSNHDAATWADPQE 331 Query: 407 FDPHHF 412 F P F Sbjct: 332 FRPERF 337 >3OO3-A nrPDB Length = 384 Score = 38.1 bits (87), Expect = 0.010, Method: Compositional matrix adjust. Identities = 39/187 (20%), Positives = 69/187 (36%), Gaps = 32/187 (17%) Query: 280 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339 +E + E L A E + L A+LLL+ HP+ A ++E+ E + Sbjct: 209 AEISDEELAGLAEGNLIMAAEQMAAQLAVAVLLLVTHPDQMALLREKPELI--------- 259 Query: 340 QDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNK 399 D+ EV R+ ++ P D++ I G + S+ + Sbjct: 260 ---------DSATEEVLRHASIVEAPAPRVALADVRMAGRDIHAGDVLTCSMLA----TN 306 Query: 400 EFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLK 459 P + FD ++ M F G C+G LA ++L + L +++ F Sbjct: 307 RAPG-DRFD---------ITREKATHMAFGHGIHHCIGAPLARLQLRVALPAVVGRFPSL 356 Query: 460 SLVDPKN 466 L P+ Sbjct: 357 RLAVPEE 363 >3IVY-A nrPDB Length = 433 Score = 38.1 bits (87), Expect = 0.010, Method: Compositional matrix adjust. Identities = 49/221 (22%), Positives = 85/221 (38%), Gaps = 53/221 (23%) Query: 267 FLMKMEKEKHNQPSEFTIESL-------ENTAVDLFG--------AGTETTSTTLRYALL 311 + MKM +EK P++ + L E + D FG AG ETT ++ ++ Sbjct: 223 YAMKMAEEKAKNPADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMM 282 Query: 312 LLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVT 371 +HP+ Q E+ + + P T A E+ R+ + T+ Sbjct: 283 AFAEHPD-----QWELYKKV-------------RPETAA--DEIVRWATPV-TAFQRTAL 321 Query: 372 CDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMF----DPHHFLDEGGNFKKSKYFMP 427 D + I KG +++ S D + F +P F +P+ + GG Sbjct: 322 RDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILRNPNPHVGFGGT--------- 372 Query: 428 FSAGKRICVGEALAGMELFLFLTSILQNF-NLKSLVDPKNL 467 G C+G LA M + L ++ + +LK + P+ L Sbjct: 373 ---GAHYCIGANLARMTINLIFNAVADHMPDLKPISAPERL 410 >5HDI-A nrPDB Length = 404 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 65/175 (37%), Gaps = 33/175 (18%) Query: 292 VDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAV 351 V LF AG E+T+ L A+ +L P++ +V R++ A Sbjct: 239 VTLFAAGGESTAALLGSAVWILATRPDIQQQV------------------RANPELLGAF 280 Query: 352 VHEVQRYIDLLPTSLPH---AVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFD 408 + E RY H A T D +P + +L+ + D +F P F Sbjct: 281 IEETLRYEPPFRGHYRHVRNATTLD----GTELPADSHLLLLWGAANRDPAQFEAPGEFR 336 Query: 409 PHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVD 463 LD G K + F G CVG ALA +E + L +L ++ D Sbjct: 337 ----LDRAGG----KGHISFGKGAHFCVGAALARLEARIVLRLLLDRTSVIEAAD 383 >1GWI-A nrPDB Length = 411 Score = 37.7 bits (86), Expect = 0.010, Method: Compositional matrix adjust. Identities = 55/218 (25%), Positives = 80/218 (36%), Gaps = 37/218 (16%) Query: 261 QDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVT 320 D + E H +E +T + AG ETT + + A++ L HPE Sbjct: 211 DDLTSALIQASENGDHLTDAEIV-----STLQLMVAAGHETTISLIVNAVVNLSTHPEQR 265 Query: 321 AKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTS--LPHAVTCDIKFRN 378 A V S AVV E R+ PTS L D+ + Sbjct: 266 ALVL------------------SGEAEWSAVVEETLRFS--TPTSHVLIRFAAEDVPVGD 305 Query: 379 YLIPKGTTILISLTSVLHDNKEF-PNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVG 437 +IP G +++S ++ D + P + FD GN S F G +C G Sbjct: 306 RVIPAGDALIVSYGALGRDERAHGPTADRFD---LTRTSGNRHIS-----FGHGPHVCPG 357 Query: 438 EALAGMELFLFLTSILQNF-NLKSLVDPKNLDTTPVVN 474 AL+ ME + L ++ F +L V L PVV Sbjct: 358 AALSRMEAGVALPALYARFPHLDLAVPAAELRNKPVVT 395 >5Z9I-A nrPDB Length = 398 Score = 37.7 bits (86), Expect = 0.011, Method: Compositional matrix adjust. Identities = 26/104 (25%), Positives = 46/104 (44%), Gaps = 13/104 (12%) Query: 341 DRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKE 400 DRS +P A++ E RY+ + + A +++ +IPK +L+ + D ++ Sbjct: 266 DRSLVP---ALLEESMRYMSPI-CGVGRATNSEVEVAGTVIPKDQLLLVWTGAANRDERQ 321 Query: 401 FPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGME 444 F P++FD + + F G C+G LA ME Sbjct: 322 FEKPDVFDAG---------RSPNAHLGFGRGIHFCLGRQLARME 356 >2X9P-A nrPDB Length = 404 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 38/174 (21%), Positives = 66/174 (37%), Gaps = 28/174 (16%) Query: 280 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339 E T + + + A+ L AG ++ ++ + ++LL HP+ R+ + Sbjct: 224 GELTEDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPD---------------QRAAAL 268 Query: 340 QDRSHMPYT-DAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDN 398 D M + V+ + +LP P + D++F I G +L L D Sbjct: 269 ADPDVMARAVEEVLRTARAGGSVLP---PRYASEDMEFGGVTIRAGDLVLFDLGLPNFDE 325 Query: 399 KEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSI 452 + F PE FD + + F G C+G LA +EL T + Sbjct: 326 RAFTGPEEFD---------AARTPNPHLTFGHGIWHCIGAPLARLELRTMFTKL 370 >2XKR-A nrPDB Length = 398 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 42/177 (23%), Positives = 70/177 (39%), Gaps = 19/177 (10%) Query: 310 LLLLLKHPEVTAKVQEEIERVIGRNRSP---CMQDRSHMPYTDAVVHEVQRYIDLLPTSL 366 LL+L+ E T + RNR +D S +P + E+ R+ + ++ Sbjct: 225 LLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRDPSLLP---GAIEEMLRWTAPV-KNM 280 Query: 367 PHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFM 426 +T D +F + G +++ S D F PE FD + + Sbjct: 281 CRVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQ---------RNPNSHL 331 Query: 427 PFSAGKRICVGEALAGMELFLFLTSILQNF-NLKSLVDPKNLDTTPV--VNGFASVP 480 F G C+G LA +EL L +L+ +L+ + D L P V+G S+P Sbjct: 332 AFGFGTHFCLGNQLARLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMP 388 >3RWL-A nrPDB Length = 426 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 54/262 (20%), Positives = 108/262 (41%), Gaps = 48/262 (18%) Query: 222 IIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSE 281 +++ + +LL+ A+ + E+V + +P + + L ++ P E Sbjct: 203 VVESWDQRKTELLECAAYFQVLWNERVNK--------DPGNDLISMLAHSPATRNMTPEE 254 Query: 282 FTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQD 341 + L N + + G G +TT ++ +L L K+P+ AK++ +P + Sbjct: 255 Y----LGNVLLLIVG-GNDTTRNSMTGGVLALHKNPDQFAKLKA----------NPAL-- 297 Query: 342 RSHMPYTDAVVHEVQRYIDLLPTSLPH---AVTCDIKFRNYLIPKGTTILISLTSVLHDN 398 + +V E+ R+ T L H D + I KG +++ S D+ Sbjct: 298 ------VETMVPEIIRW----QTPLAHMRRTAIADSELGGKTIRKGDKVVMWYYSGNRDD 347 Query: 399 KEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFN- 457 + PE F +D + + + F G CVG LA M+L + IL F+ Sbjct: 348 EVIDRPEEF----IIDR----PRPRQHLSFGFGIHRCVGNRLAEMQLRILWEEILTRFSR 399 Query: 458 LKSLVDPKNLDTTPVVNGFASV 479 ++ + +P+ + + V G+A + Sbjct: 400 IEVMAEPERVRSN-FVRGYAKM 420 >4JBT-A nrPDB Length = 410 Score = 37.4 bits (85), Expect = 0.016, Method: Compositional matrix adjust. Identities = 52/228 (22%), Positives = 87/228 (38%), Gaps = 36/228 (15%) Query: 230 HNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLEN 289 ++ L+ + M Y E V+ P D + L+ + E I +L+ Sbjct: 186 QDERLRVIDEMHGYFTEMVRRKTA-----EPGDDLTSALIYATDGETPLTEEEVIGNLQA 240 Query: 290 TAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTD 349 L AG ETT + + A+ LL HPE V++ IG + R P Sbjct: 241 ----LVAAGHETTVSLILTAVRALLSHPEQLRLVRDG---EIGWETAIEETLRWDGP--- 290 Query: 350 AVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHD-NKEFPNPEMFD 408 V+H + R+ T DI + +IP+G +++S ++ D + + FD Sbjct: 291 -VIHLLMRF-----------ATEDIDLGDAVIPRGEGVVMSYRAIGRDITVHGADADDFD 338 Query: 409 PHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456 + + F G IC G ALA +E + L ++ F Sbjct: 339 I--------TRATAARHISFGHGPHICPGAALARLEAAIALPALFTRF 378 >5GWE-A nrPDB Length = 405 Score = 36.2 bits (82), Expect = 0.030, Method: Compositional matrix adjust. Identities = 45/193 (23%), Positives = 76/193 (39%), Gaps = 31/193 (16%) Query: 262 DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTA 321 D + L++ ++E E T + + L AG ETT+T + +LL HPE Sbjct: 211 DNLTADLVRAQQEGQ----EITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQ 266 Query: 322 KVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLI 381 + E +P + +P A V EV RY + A+ D + I Sbjct: 267 AILE----------NPKL-----IP---AAVDEVLRYSGSIVGWRRKALK-DTEIGGVAI 307 Query: 382 PKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALA 441 +G +L+ + S D F N E FD + ++ + F G C+G LA Sbjct: 308 KEGDGVLLLMGSANRDEARFENGEEFDI--------SRANAREHLSFGFGIHYCLGNMLA 359 Query: 442 GMELFLFLTSILQ 454 ++ + L + + Sbjct: 360 KLQAKICLEEVTR 372 >5LIE-A nrPDB Length = 414 Score = 36.2 bits (82), Expect = 0.033, Method: Compositional matrix adjust. Identities = 38/171 (22%), Positives = 64/171 (37%), Gaps = 28/171 (16%) Query: 294 LFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVH 353 LF AG ETT ++ LL L ++P+ ++ + E + + Sbjct: 250 LFSAGAETTRNSIAGGLLALAENPDQLQTLRSDFELL------------------PTAIE 291 Query: 354 EVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFL 413 E+ R+ P+ A + I G +++ S D P +FD Sbjct: 292 EIVRWTSPSPSKRRTASRA-VSLGGQPIEAGQKVVVWEGSANRD------PSVFD---RA 341 Query: 414 DEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDP 464 DE +K + F G C+G LA +EL + +L F +V+P Sbjct: 342 DEFDITRKPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFGSVRVVEP 392 >2ZQJ-A nrPDB Length = 417 Score = 36.2 bits (82), Expect = 0.033, Method: Compositional matrix adjust. Identities = 22/68 (32%), Positives = 32/68 (47%), Gaps = 1/68 (1%) Query: 352 VHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHH 411 V EV+RY P L V D + N KGT++L+ L HD + + +P+ F P Sbjct: 280 VQEVRRYYPFGPF-LGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEFRPER 338 Query: 412 FLDEGGNF 419 F + N Sbjct: 339 FAEREENL 346 >5XNT-A nrPDB Length = 411 Score = 36.2 bits (82), Expect = 0.033, Method: Compositional matrix adjust. Identities = 48/200 (24%), Positives = 80/200 (40%), Gaps = 34/200 (17%) Query: 259 NPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALL-LLLKHP 317 NP D I L+K E + FT + + T + + GAG ETTS L + LL Sbjct: 209 NPADDIISDLLKAEVDGEM----FTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYDDK 264 Query: 318 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRY-IDLLPTSLPHAVTCDIKF 376 EV ++ E ++ V V E+ RY +L+ L V D Sbjct: 265 EVYQELHENLDLV------------------PQAVEEMLRYRFNLI--KLDRTVKEDNDL 304 Query: 377 RNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICV 436 + +G +++ +++ D + F + + H +K + F G C+ Sbjct: 305 LGVELKEGENVVVWMSAANLDEEMFEDAFTLNIHR--------PNNKKHLTFGNGPHFCL 356 Query: 437 GEALAGMELFLFLTSILQNF 456 G LA +E + LT+ L+ F Sbjct: 357 GAPLARLEAKIALTTFLKKF 376 >5XJN-A nrPDB Length = 455 Score = 36.2 bits (82), Expect = 0.037, Method: Compositional matrix adjust. Identities = 45/193 (23%), Positives = 76/193 (39%), Gaps = 31/193 (16%) Query: 262 DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTA 321 D + L++ ++E E T + + L AG ETT+T + +LL HPE Sbjct: 261 DNLTADLVRAQQEGQ----EITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQ 316 Query: 322 KVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLI 381 + E +P + +P A V EV RY + A+ D + I Sbjct: 317 AILE----------NPKL-----IP---AAVDEVLRYSGSIVGWRRKALK-DTEIGGVAI 357 Query: 382 PKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALA 441 +G +L+ + S D F N E FD + ++ + F G C+G LA Sbjct: 358 KEGDGVLLLMGSANRDEARFENGEEFDI--------SRANAREHLSFGFGIHYCLGNMLA 409 Query: 442 GMELFLFLTSILQ 454 ++ + L + + Sbjct: 410 KLQAKICLEEVTR 422 >4XE3-A nrPDB Length = 407 Score = 35.4 bits (80), Expect = 0.053, Method: Compositional matrix adjust. Identities = 43/205 (20%), Positives = 77/205 (37%), Gaps = 33/205 (16%) Query: 261 QDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVT 320 +D + + + + H T + N V L AG ET+ + + LLL Sbjct: 213 EDLLGALALATDNDDH-----LTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLT----- 262 Query: 321 AKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPT-SLPHAVTCDIKFRNY 379 ER + + D + +P A V E+ RY L+ S T D++ Sbjct: 263 -------ER---KRYESLVADPALVP---AAVEEMLRYTPLVSAGSFVRVATEDVELSTV 309 Query: 380 LIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEA 439 + G ++ S D + F + + D H ++ + F G C+G Sbjct: 310 TVRAGEPCVVHFASANRDEEVFDHADELDFH---------RERNPHIAFGHGAHHCIGAQ 360 Query: 440 LAGMELFLFLTSILQNFNLKSLVDP 464 L +EL L+++++ F L +P Sbjct: 361 LGRLELQEALSALVRRFPTLDLAEP 385 >6G71-A nrPDB Length = 405 Score = 35.4 bits (80), Expect = 0.055, Method: Compositional matrix adjust. Identities = 22/93 (23%), Positives = 38/93 (40%), Gaps = 12/93 (12%) Query: 350 AVVHEVQRYIDLLPTSL-PHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFD 408 AV E R++ P + P D + Y IP+G + + + S D + +P+ FD Sbjct: 271 AVFEESIRWV--APIGMVPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWSDPDRFD 328 Query: 409 PHHFLDEGGNFKKSKYFMPFSAGKRICVGEALA 441 + S+ + F G +C+G A Sbjct: 329 IE---------RGSEAHLAFGKGVHVCLGAWAA 352 >3ABA-A nrPDB Length = 403 Score = 34.7 bits (78), Expect = 0.100, Method: Compositional matrix adjust. Identities = 38/178 (21%), Positives = 66/178 (37%), Gaps = 27/178 (15%) Query: 287 LENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMP 346 L N A L A +TT+ + LLL P+ A ++E+ P + + Sbjct: 227 LMNAAGTLLIAAHDTTACMIGLGTALLLDSPDQLALLRED----------PSLVGNA--- 273 Query: 347 YTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEM 406 V E+ RY+ + T D++ I KG ++ + + D PE Sbjct: 274 -----VEELLRYLTIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPER 328 Query: 407 FDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDP 464 FD ++ + F G C+G+ LA +EL + ++ + L P Sbjct: 329 FD---------ITRRPAPHLAFGFGAHQCIGQQLARIELQIVFETLFRRLPGLRLAKP 377 >5L94-A nrPDB Length = 410 Score = 34.3 bits (77), Expect = 0.11, Method: Compositional matrix adjust. Identities = 47/227 (20%), Positives = 89/227 (39%), Gaps = 48/227 (21%) Query: 245 LEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQP---------------SEFTIESLEN 289 LEK++ QE M N D ++ + ++ +EK +P + T E + Sbjct: 180 LEKLQ--QEKMKAN---DELETYFYRIIEEKRTRPGDDIISVLLQAKEEGKQLTDEEIVG 234 Query: 290 TAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTD 349 ++ L AG ETT+ + + L++ +++ E E + Sbjct: 235 FSILLLIAGNETTTNLISNTIYCLMEDKASFERLKREKELL------------------P 276 Query: 350 AVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDP 409 + + EV RY + +L V D+ + G ++ + S D + F +PE+F Sbjct: 277 SGIEEVLRYRSPV-QALHRIVKEDVTLAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFK- 334 Query: 410 HHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456 +D +K M F G C+G LA +E + L ++ + Sbjct: 335 ---ID-----RKPNVHMAFGRGIHFCLGAPLARIEAKIMLAELIDRY 373 >2WM5-A nrPDB Length = 435 Score = 34.3 bits (77), Expect = 0.14, Method: Compositional matrix adjust. Identities = 36/153 (23%), Positives = 56/153 (36%), Gaps = 34/153 (22%) Query: 297 AGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQ 356 AG ETT + + +L L ++PE R D + T V E+ Sbjct: 274 AGNETTRNAITHGVLALSRYPE---------------QRDRWWSDFDGLAPT--AVEEIV 316 Query: 357 RYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFD----PHHF 412 R+ + + +T DI+ R + G + + S D +F +P FD P+ Sbjct: 317 RWASPV-VYMRRTLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLARNPNPH 375 Query: 413 LDEGGNFKKSKYFMPFSAGKRICVGEALAGMEL 445 L GG G C+G LA E+ Sbjct: 376 LGFGG------------GGAHFCLGANLARREI 396 >4TRI-A nrPDB Length = 407 Score = 33.9 bits (76), Expect = 0.19, Method: Compositional matrix adjust. Identities = 39/159 (24%), Positives = 57/159 (35%), Gaps = 28/159 (17%) Query: 344 HMPYTDAVVHEVQRYIDLLPTSLP-------------HAVTCDIKFRNYLIPKGTTILIS 390 H DA+V +V DLLP ++ +T D F + G I++ Sbjct: 252 HRDQWDALVADV----DLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRAGEKIMLM 307 Query: 391 LTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLT 450 S D F +P+ F +D N + F G C+G LA +EL L Sbjct: 308 FESANFDESVFGDPDNF----RIDRNPN-----SHVAFGFGTHFCLGNQLARLELRLMTE 358 Query: 451 SILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIP 489 +L+ L D + P F S P + F P Sbjct: 359 RVLRRLPDLRLADDAPVPLRPA--NFVSGPESMPVVFTP 395 >6CVC-A nrPDB Length = 433 Score = 33.1 bits (74), Expect = 0.30, Method: Compositional matrix adjust. Identities = 35/175 (20%), Positives = 66/175 (37%), Gaps = 39/175 (22%) Query: 280 SEFTIESLENTAVDLF-----GAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRN 334 +E E L ++ + +F AG ETT + + +L L ++P+ AK + + + Sbjct: 249 AEVDGERLSSSEIAMFFILLVVAGNETTRNAISHGMLALSRYPDERAKWWSDFDGLAA-- 306 Query: 335 RSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSV 394 V E+ R+ + + ++ D+ R + G + + S Sbjct: 307 ---------------TAVEEIVRWASPV-VYMRRTLSQDVDLRGTKMAAGDKVTLWYCSA 350 Query: 395 LHDNKEFPNPEMFD----PHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMEL 445 D ++F +P FD P+ + GG G C+G LA E+ Sbjct: 351 NRDEEKFADPWTFDVTRNPNPQVGFGG------------GGAHFCLGANLARREI 393 >4Z5P-A nrPDB Length = 400 Score = 33.1 bits (74), Expect = 0.31, Method: Compositional matrix adjust. Identities = 45/231 (19%), Positives = 90/231 (38%), Gaps = 39/231 (16%) Query: 238 AFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGA 297 A +++Y+ + V + + P D + L+ + T + L V L A Sbjct: 187 ASIRAYLADLVSARRAA-----PHDDLLGVLVSARDDD----DRLTEDELITFGVTLLVA 237 Query: 298 GTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQR 357 G ET++ L + LL H + + ++E+ P + R+ V E+ R Sbjct: 238 GHETSAHQLGNMVYALLTHEDQLSLLREQ----------PELLPRA--------VEELLR 279 Query: 358 YIDLLPTSLPHAVTC--DIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDE 415 ++ L + +A D++ + G ++ + + D + F +P+ D Sbjct: 280 FVPL-GNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLD------- 331 Query: 416 GGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKN 466 ++ + F G C+G LA MEL + + +L+ F L P + Sbjct: 332 --ITREKNPHLAFGHGAHYCLGAQLARMELRVAIGGLLERFPGLRLAVPAD 380 >3B98-A nrPDB Length = 475 Score = 32.3 bits (72), Expect = 0.47, Method: Compositional matrix adjust. Identities = 50/193 (25%), Positives = 79/193 (40%), Gaps = 27/193 (13%) Query: 308 YALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLP 367 + + LL HPE V+EEI+ G + + + P D+V+ E R + Sbjct: 275 WVMGYLLTHPEALRAVREEIQ---GGKHLRLEERQKNTPVFDSVLWETLRLT--AAALIT 329 Query: 368 HAVTCDIKF-----RNYLIPKGTTILI-SLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKK 421 VT D K + Y + +G + + S D + PEMF FL+ KK Sbjct: 330 RDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKK 389 Query: 422 S--------KY-FMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPV 472 KY +P+ +C G A + + +IL F+++ L D KN T P+ Sbjct: 390 DFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVE-LCD-KNA-TVPL 446 Query: 473 VN----GFASVPP 481 V+ GF + P Sbjct: 447 VDPSRYGFGILQP 459 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 22/66 (33%), Positives = 37/66 (56%), Gaps = 4/66 (6%) Query: 21 RQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLY-FGLKPIVVLHG 79 R++ R + P +P +G+ L+ G KD +K LT + + +G +FT+ GL V+L Sbjct: 12 RRTRRRNEPPLDKGMIPWLGHALEFG-KDAAKFLTRMKEKHGDIFTVRAAGLYITVLLDS 70 Query: 80 --YEAV 83 Y+AV Sbjct: 71 NCYDAV 76 >2QBO-A nrPDB Length = 421 Score = 32.3 bits (72), Expect = 0.48, Method: Compositional matrix adjust. Identities = 49/255 (19%), Positives = 92/255 (36%), Gaps = 47/255 (18%) Query: 243 YILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVD--------- 293 Y+ +++ SM ++ + +L+ + +++ +P I + N V+ Sbjct: 180 YLTDQMTRPDGSMTFAEAKEALYDYLIPIIEQRRQKPGTDAISIVANGQVNGRPITSDEA 239 Query: 294 ------LFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPY 347 L G +T L +++ L K PE ++ E ER+ Sbjct: 240 KRMCGLLLVVGLDTVVNFLSFSMEFLAKSPEHRQELIERPERI----------------- 282 Query: 348 TDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMF 407 A E+ R L+ +T D +F + KG IL+ D +E P Sbjct: 283 -PAACEELLRRFSLVADG--RILTSDYEFHGVQLKKGDQILLPQMLSGLDERENACPMHV 339 Query: 408 DPHHFLDEGGNFKKSKY-FMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKN 466 D F + K F G +C+G+ LA E+ + L L S+ Sbjct: 340 D----------FSRQKVSHTTFGHGSHLCLGQHLARREIIVTLKEWLTRIPDFSIAPGAQ 389 Query: 467 LD-TTPVVNGFASVP 480 + + +V+G ++P Sbjct: 390 IQHKSGIVSGVQALP 404 >1EHE-A nrPDB Length = 403 Score = 31.6 bits (70), Expect = 0.92, Method: Compositional matrix adjust. Identities = 38/180 (21%), Positives = 69/180 (38%), Gaps = 26/180 (14%) Query: 294 LFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVH 353 L AG T + + L +HP+ A+++ +P + + V Sbjct: 236 LLVAGNATMVNMIALGVATLAQHPDQLAQLKA----------NPSLAPQ--------FVE 277 Query: 354 EVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFL 413 E+ RY ++ D+ + L+ I+ S S D + F NP+ F+ + Sbjct: 278 ELCRYHTASALAIKRTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNRKW 337 Query: 414 DEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF-NLKSLVDPKNLDTTPV 472 + + F G C+ E LA EL +++ Q F +LK V ++ TP+ Sbjct: 338 -------PPQDPLGFGFGDHRCIAEHLAKAELTTVFSTLYQKFPDLKVAVPLGKINYTPL 390 >5OMS-A nrPDB Length = 409 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 15/57 (26%), Positives = 24/57 (42%), Gaps = 9/57 (15%) Query: 381 IPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVG 437 +P GT +++S S HD ++ P +D H + + F AG C G Sbjct: 313 LPAGTPVMLSYGSANHDTGKYEAPSQYDLH---------RPPLPHLAFGAGNHACAG 360 >3WEC-A nrPDB Length = 419 Score = 30.0 bits (66), Expect = 2.1, Method: Compositional matrix adjust. Identities = 50/238 (21%), Positives = 98/238 (41%), Gaps = 45/238 (18%) Query: 235 KNVAFMKSYILEKVKEHQESMDM--NNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAV 292 K VA +S +E+ ++ ++ N P+ L++ E + + +++ + T + Sbjct: 194 KEVADRRSAAIEESIDYFRTLATSGNAPEG-----LVRRLSEVSHGGDQLSVDEIAATCL 248 Query: 293 DLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVV 352 + AG ETTS T+ L+ +H ++ E+V R++ + + V Sbjct: 249 LITVAGQETTSNTIGNMLITFSRH-------ADQFEQV-----------RANPQFIENAV 290 Query: 353 HEVQRYIDLLPTSLPHAV-TCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHH 411 EV R+ + A+ C++ N I KG +++ L S N+E Sbjct: 291 AEVLRFEPPAHEAGRIALEDCEVSGAN--ITKGDAVMVLLAS---GNREA---------- 335 Query: 412 FLDEGGNFKKSK---YFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKN 466 ++ G F ++ + + G C+G ALA L FL + Q + + +P N Sbjct: 336 -VERGDTFSVTRPDVSSLSYGRGIHHCLGSALANSMLQHFLRELSQRYRSIEVAEPIN 392 >1PIO-A nrPDB Length = 257 Score = 29.6 bits (65), Expect = 3.5, Method: Compositional matrix adjust. Identities = 21/80 (26%), Positives = 37/80 (46%) Query: 113 VFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC 172 + +NGK KE ++F L + N G I+D V ++ + + + T AS D F+ Sbjct: 161 LIANGKLSKENKKFLLDLMLNNKSGDTLIKDGVPKDYKVADKSGQSTYASRNDVAFVYPK 220 Query: 173 APCNVICSIIFHKRFDYKDQ 192 I +IF + + D+ Sbjct: 221 GQSEPIVLVIFTNKDNKSDK 240 >4CQI-A nrPDB Length = 127 Score = 28.9 bits (63), Expect = 5.5, Method: Composition-based stats. Identities = 21/83 (25%), Positives = 37/83 (44%), Gaps = 3/83 (3%) Query: 305 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPT 364 TLR + L + + + E+ER + R + C D +P VV E Q ++P Sbjct: 27 TLRIKVSALKRTIKDLEFAKREVERELQRLDTLCQSDPDRVPQQTKVVDEAQM---MVPH 83 Query: 365 SLPHAVTCDIKFRNYLIPKGTTI 387 S+ + +YL +G+T+ Sbjct: 84 SVNRIMASVKDLSDYLEKEGSTV 106 >4DJD-D nrPDB Length = 323 Score = 28.9 bits (63), Expect = 5.6, Method: Compositional matrix adjust. Identities = 14/36 (38%), Positives = 24/36 (66%), Gaps = 2/36 (5%) Query: 301 TTSTTL--RYALLLLLKHPEVTAKVQEEIERVIGRN 334 T+T L A +LL++HPE A+V+E I++++ N Sbjct: 286 VTATALLQAGAHILLMRHPEAVARVKENIDQLMVSN 321 >3Q5X-A nrPDB Length = 245 Score = 28.1 bits (61), Expect = 9.2, Method: Compositional matrix adjust. Identities = 19/55 (34%), Positives = 27/55 (49%), Gaps = 11/55 (20%) Query: 350 AVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNP 404 AV+H + D++P LP TC K T L + T+V+H+ EF NP Sbjct: 133 AVLHALN---DMVPCYLPPYSTC--------FEKNITFLDAATNVVHELPEFHNP 176 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5W0C-A nrPDB 665 0.0 4GQS-A nrPDB 645 0.0 2NNH-A nrPDB 629 0.0 1N6B-A nrPDB 615 e-177 3E6I-A nrPDB 570 e-163 4H1N-A nrPDB 563 e-161 3IBD-A nrPDB 541 e-154 2PG7-A nrPDB 540 e-154 5E0E-A nrPDB 533 e-152 5E58-A nrPDB 526 e-150 6B82-A nrPDB 438 e-123 3TBG-A nrPDB 431 e-121 6DWN-A nrPDB 427 e-120 3DL9-A nrPDB 414 e-116 4R20-A nrPDB 408 e-114 2HI4-A nrPDB 402 e-112 5UYS-A nrPDB 389 e-108 4R1Z-A nrPDB 384 e-107 5VBU-A nrPDB 372 e-103 6IQ5-A nrPDB 364 e-101 3QZ1-A nrPDB 356 1e-98 5YLW-A nrPDB 342 2e-94 6DA2-A nrPDB 334 5e-92 5VEU-A nrPDB 325 3e-89 6AYB-A nrPDB 325 4e-89 2WX2-A nrPDB 316 2e-86 3L4D-A nrPDB 311 5e-85 3JUS-A nrPDB 309 2e-84 3K9V-A nrPDB 306 2e-83 2X2N-A nrPDB 283 2e-76 3MDV-A nrPDB 271 5e-73 5FSA-A nrPDB 256 2e-68 4WMZ-A nrPDB 256 2e-68 5JLC-A nrPDB 254 5e-68 6CR2-A nrPDB 251 6e-67 2W0A-A nrPDB 232 3e-61 6C94-A nrPDB 231 5e-61 2VE3-A nrPDB 227 8e-60 2VZM-A nrPDB 225 3e-59 5L1U-A nrPDB 223 1e-58 3EL3-A nrPDB 219 2e-57 3EJB-B nrPDB 218 3e-57 3N9Z-A nrPDB 216 2e-56 2Y5N-A nrPDB 215 3e-56 4ZGX-A nrPDB 211 5e-55 3MZS-A nrPDB 210 1e-54 6M7X-A nrPDB 209 3e-54 5CJE-A nrPDB 208 4e-54 1Z8P-A nrPDB 208 7e-54 5VWS-A nrPDB 207 9e-54 5EX6-C nrPDB 207 1e-53 4OQS-A nrPDB 205 4e-53 4OQR-A nrPDB 203 2e-52 5Y1I-A nrPDB 203 2e-52 3WVS-A nrPDB 201 5e-52 2ZBZ-A nrPDB 201 6e-52 4KPA-A nrPDB 198 5e-51 2Z36-A nrPDB 197 1e-50 4TX3-A nrPDB 197 1e-50 4UBS-A nrPDB 196 2e-50 4WPZ-A nrPDB 196 2e-50 6FSH-A nrPDB 192 4e-49 3ABB-A nrPDB 190 1e-48 3R9C-A nrPDB 189 3e-48 4YZR-A nrPDB 189 3e-48 5FOI-A nrPDB 189 3e-48 6A7J-A nrPDB 188 4e-48 5YSW-A nrPDB 187 1e-47 3SN5-A nrPDB 186 2e-47 3TYW-A nrPDB 186 2e-47 5IT1-A nrPDB 186 3e-47 6GMF-A nrPDB 185 3e-47 4MM0-A nrPDB 184 7e-47 1LG9-A nrPDB 183 1e-46 6GK6-A nrPDB 183 1e-46 6A7I-A nrPDB 182 2e-46 4RM4-A nrPDB 182 3e-46 6B11-A nrPDB 180 1e-45 1ODO-A nrPDB 179 2e-45 1CPT-A nrPDB 177 7e-45 4GGV-A nrPDB 176 2e-44 6M7L-A nrPDB 176 3e-44 3P3Z-A nrPDB 175 3e-44 3S79-A nrPDB 174 9e-44 3MGX-A nrPDB 171 9e-43 5HH3-A nrPDB 168 4e-42 6F0B-A nrPDB 166 2e-41 3TKT-A nrPDB 162 3e-40 3A1L-A nrPDB 161 7e-40 5LIV-A nrPDB 154 6e-38 1Q5D-A nrPDB 154 7e-38 6F88-A nrPDB 154 9e-38 5EX8-A nrPDB 152 2e-37 2RFC-A nrPDB 147 1e-35 1WIY-A nrPDB 134 6e-32 2IJ7-A nrPDB 129 2e-30 2IAG-A nrPDB 119 2e-27 6FYJ-A nrPDB 114 1e-25 5YHJ-A nrPDB 109 4e-24 5M0P-A nrPDB 101 7e-22 Sequences not found previously or not previously below threshold: 3A50-A nrPDB 200 1e-51 5L94-A nrPDB 197 1e-50 4Z5P-A nrPDB 195 4e-50 3ABA-A nrPDB 184 8e-47 4JBT-A nrPDB 179 2e-45 4Z5Q-A nrPDB 179 3e-45 1UED-A nrPDB 176 2e-44 5NWS-A nrPDB 176 3e-44 1GWI-A nrPDB 174 6e-44 5OFQ-A nrPDB 173 1e-43 4XE3-A nrPDB 171 5e-43 5GWE-A nrPDB 169 3e-42 5XJN-A nrPDB 169 4e-42 5LIE-A nrPDB 168 4e-42 1EHE-A nrPDB 167 1e-41 5XW2-A nrPDB 166 2e-41 5DE9-A nrPDB 164 8e-41 3NC3-A nrPDB 164 1e-40 5XNT-A nrPDB 163 2e-40 2WIO-A nrPDB 161 5e-40 4YT3-A nrPDB 160 1e-39 4TRI-A nrPDB 154 6e-38 6HQG-A nrPDB 154 8e-38 5Z9I-A nrPDB 154 1e-37 3OO3-A nrPDB 152 4e-37 2FR7-A nrPDB 151 1e-36 2WM5-A nrPDB 150 1e-36 2NZA-A nrPDB 149 2e-36 2X9P-A nrPDB 149 2e-36 3RWL-A nrPDB 146 2e-35 6CVC-A nrPDB 145 4e-35 2XKR-A nrPDB 145 5e-35 5FYF-A nrPDB 144 6e-35 1F4U-A nrPDB 144 9e-35 6HQW-A nrPDB 144 9e-35 1UE8-A nrPDB 141 8e-34 5HIW-A nrPDB 140 9e-34 4DO1-A nrPDB 139 2e-33 5HDI-A nrPDB 139 2e-33 6GII-A nrPDB 139 4e-33 5DQN-A nrPDB 135 6e-32 4PWV-A nrPDB 133 1e-31 6DCD-A nrPDB 132 3e-31 2UUQ-A nrPDB 132 3e-31 5H1Z-A nrPDB 131 6e-31 6G5O-A nrPDB 131 7e-31 3WEC-A nrPDB 130 1e-30 3IVY-A nrPDB 129 3e-30 2WIY-A nrPDB 123 2e-28 3OFT-A nrPDB 122 3e-28 6G71-A nrPDB 121 6e-28 3BUJ-A nrPDB 119 4e-27 3B98-A nrPDB 119 4e-27 6HQD-A nrPDB 118 5e-27 4FB2-A nrPDB 118 6e-27 6BLD-A nrPDB 117 9e-27 2QBO-A nrPDB 116 2e-26 5D3U-A nrPDB 116 3e-26 5OMS-A nrPDB 115 4e-26 5KYO-A nrPDB 109 3e-24 2ZQJ-A nrPDB 100 2e-21 3NV6-A nrPDB 99 5e-21 4C9K-A nrPDB 91 1e-18 3AWQ-A nrPDB 91 2e-18 2RCM-A nrPDB 82 8e-16 3DBM-A nrPDB 71 1e-12 2YJN-B nrPDB 59 7e-09 4YXC-B nrPDB 36 0.034 4YXB-D nrPDB 33 0.26 4DJD-D nrPDB 32 0.52 5C8J-I nrPDB 29 3.5 6FEC-u nrPDB 29 3.6 2NYG-A nrPDB 29 6.4 3RFT-A nrPDB 29 6.9 4YB9-D nrPDB 28 8.0 >5W0C-A nrPDB Length = 477 Score = 665 bits (1715), Expect = 0.0, Method: Composition-based stats. Identities = 465/473 (98%), Positives = 470/473 (99%), Gaps = 1/473 (0%) Query: 19 LWRQSSG-RGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVL 77 + +++S RGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVL Sbjct: 1 MAKKTSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVL 60 Query: 78 HGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMG 137 HGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMG Sbjct: 61 HGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMG 120 Query: 138 KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNL 197 KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNL Sbjct: 121 KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNL 180 Query: 198 MEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDM 257 MEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDM Sbjct: 181 MEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDM 240 Query: 258 NNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 317 NNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP Sbjct: 241 NNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 300 Query: 318 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFR 377 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFR Sbjct: 301 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFR 360 Query: 378 NYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVG 437 NYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVG Sbjct: 361 NYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVG 420 Query: 438 EALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV 490 EALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIP+ Sbjct: 421 EALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPI 473 >4GQS-A nrPDB Length = 477 Score = 645 bits (1665), Expect = 0.0, Method: Composition-based stats. Identities = 425/473 (89%), Positives = 449/473 (94%), Gaps = 1/473 (0%) Query: 19 LWRQSSG-RGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVL 77 + +++S RGKLPPGPTPLPVIGNILQI IKD+SKSLTNLSK+YGPVFTLYFGL+ +VVL Sbjct: 1 MAKKTSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVL 60 Query: 78 HGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMG 137 HGYE VKEALIDLGEEFSGRG FPLAERANRGFGIVFSNGK+WKEIRRFSLMTLRNFGMG Sbjct: 61 HGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMG 120 Query: 138 KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNL 197 KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF KRFDYKDQQFLNL Sbjct: 121 KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNL 180 Query: 198 MEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDM 257 MEKLNENI+I+S+PWIQICNNF IIDYFPGTHNKLLKN+AFM+S ILEKVKEHQESMD+ Sbjct: 181 MEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDI 240 Query: 258 NNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP 317 NNP+DFIDCFL+KMEKEK NQ SEFTIE+L TA DL GAGTETTSTTLRYALLLLLKHP Sbjct: 241 NNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHP 300 Query: 318 EVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFR 377 EVTAKVQEEIERV+GRNRSPCMQDR HMPYTDAVVHEVQRYIDL+PTSLPHAVTCD+KFR Sbjct: 301 EVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFR 360 Query: 378 NYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVG 437 NYLIPKGTTIL SLTSVLHDNKEFPNPEMFDP HFLDEGGNFKKS YFMPFSAGKRICVG Sbjct: 361 NYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVG 420 Query: 438 EALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV 490 E LA MELFLFLT ILQNFNLKSL+DPK+LDTTPVVNGFASVPPFYQLCFIP+ Sbjct: 421 EGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPI 473 >2NNH-A nrPDB Length = 476 Score = 629 bits (1622), Expect = 0.0, Method: Composition-based stats. Identities = 366/472 (77%), Positives = 412/472 (87%) Query: 19 LWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH 78 + +++S +GKLPPGPTPLP+IGN+LQI +KDI KS TN SKVYGPVFT+YFG+ PIVV H Sbjct: 1 MAKKTSSKGKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFH 60 Query: 79 GYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK 138 GYEAVKEALID GEEFSGRG P+++R +G GI+ SNGK+WKEIRRFSL TLRNFGMGK Sbjct: 61 GYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGK 120 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLM 198 RSIEDRVQEEA CLVEELRKTKASPCDPTFILGCAPCNVICS++F KRFDYKDQ FL LM Sbjct: 121 RSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLM 180 Query: 199 EKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMN 258 ++ NEN +IL+SPWIQ+CNNF +ID FPGTHNK+LKNVA +SYI EKVKEHQ S+D+N Sbjct: 181 KRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVN 240 Query: 259 NPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPE 318 NP+DFIDCFL+KME+EK NQ SEF IE+L T DLF AGTETTSTTLRY LLLLLKHPE Sbjct: 241 NPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPE 300 Query: 319 VTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRN 378 VTAKVQEEI+ VIGR+RSPCMQDRSHMPYTDAVVHE+QRY DL+PT +PHAVT D KFRN Sbjct: 301 VTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRN 360 Query: 379 YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGE 438 YLIPKGTTI+ LTSVLHD+KEFPNP +FDP HFLD+ GNFKKS YFMPFSAGKRIC GE Sbjct: 361 YLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGE 420 Query: 439 ALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV 490 LA MELFLFLT+ILQNFNLKS+ D KNL+TT V G S+PP YQ+CFIPV Sbjct: 421 GLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV 472 >1N6B-A nrPDB Length = 473 Score = 615 bits (1587), Expect = e-177, Method: Composition-based stats. Identities = 353/472 (74%), Positives = 412/472 (87%), Gaps = 3/472 (0%) Query: 19 LWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH 78 + +++S +GKLPPGPTP P+IGNILQI KDISKSLT S+ YGPVFT+Y G+KP VVLH Sbjct: 1 MAKKTSSKGKLPPGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLH 60 Query: 79 GYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK 138 GYEAVKEAL+DLGEEF+GRG P+ E+ ++G GI FSN K WKE+RRFSLMTLRNFGMGK Sbjct: 61 GYEAVKEALVDLGEEFAGRGSVPILEKVSKGLGIAFSNAKTWKEMRRFSLMTLRNFGMGK 120 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLM 198 RSIEDR+QEEARCLVEELRKT ASPCDPTFILGCAPCNVICS+IFH RFDYKD++FL LM Sbjct: 121 RSIEDRIQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKLM 180 Query: 199 EKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMN 258 E L+EN+++L +PW+Q+ NNF ++DYFPG H LLKN ++K++I+EKVKEHQ+ +D+N Sbjct: 181 ESLHENVELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLLDVN 240 Query: 259 NPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPE 318 NP+DFIDCFL+KME+E + EFT+ESL DLFGAGTETTSTTLRY+LLLLLKHPE Sbjct: 241 NPRDFIDCFLIKMEQENNL---EFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPE 297 Query: 319 VTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRN 378 V A+VQEEIERVIGR+RSPCMQDRS MPYTDAV+HE+QR+IDLLPT+LPHAVT D++FRN Sbjct: 298 VAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFRN 357 Query: 379 YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGE 438 Y IPKGT I+ SLTSVLHD K FPNP++FDP HFLDE GNFKKS YFMPFSAGKR+CVGE Sbjct: 358 YFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRMCVGE 417 Query: 439 ALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV 490 LA MELFLFLTSILQNF L+SLV+PK+LD T VVNGF SVPP YQLCFIP+ Sbjct: 418 GLARMELFLFLTSILQNFKLQSLVEPKDLDITAVVNGFVSVPPSYQLCFIPI 469 >3E6I-A nrPDB Length = 476 Score = 570 bits (1468), Expect = e-163, Method: Composition-based stats. Identities = 273/471 (57%), Positives = 357/471 (75%), Gaps = 1/471 (0%) Query: 19 LWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH 78 + +++S +GKLPPGP PLP+IGN+ Q+ +K+I KS T L++ +GPVFTLY G + +VV+H Sbjct: 1 MAKKTSSKGKLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH 60 Query: 79 GYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK 138 GY+AVKEAL+D +EFSGRG P A+R GI+F+NG WK+IRRFSL TLRN+GMGK Sbjct: 61 GYKAVKEALLDYKDEFSGRGDLPAF-HAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGK 119 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLM 198 + E R+Q EA L+E LRKT+ P DPTF++GCAPCNVI I+F K FDY D++FL LM Sbjct: 120 QGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLM 179 Query: 199 EKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMN 258 NEN +LS+PW+Q+ NNF + Y PG+H K++KNVA +K Y+ E+VKEH +S+D N Sbjct: 180 YLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPN 239 Query: 259 NPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPE 318 P+D DC L++MEKEKH+ +T++ + T DLF AGTETTSTTLRY LL+L+K+PE Sbjct: 240 CPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPE 299 Query: 319 VTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRN 378 + K+ EEI+RVIG +R P ++DR MPY DAVVHE+QR+I L+P++LPH T D FR Sbjct: 300 IEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRG 359 Query: 379 YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGE 438 YLIPKGT ++ +L SVL+DN+EFP+PE F P HFL+E G FK S YF PFS GKR+C GE Sbjct: 360 YLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGE 419 Query: 439 ALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIP 489 LA MELFL L +ILQ+FNLK LVDPK++D +P+ GF +PP Y+LC IP Sbjct: 420 GLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIP 470 >4H1N-A nrPDB Length = 479 Score = 563 bits (1452), Expect = e-161, Method: Composition-based stats. Identities = 239/470 (50%), Positives = 343/470 (72%) Query: 19 LWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH 78 + +++S +GKLPPGP+PLPV+GN+LQ+ K + +S L + YG VFT+Y G +P+VVL Sbjct: 1 MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLC 60 Query: 79 GYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK 138 G +A++EAL+D E FSGRG + + +G+G++F+NG++W+ +RRFSL T+R+FGMGK Sbjct: 61 GTDAIREALVDQAEAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRFSLATMRDFGMGK 120 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLM 198 RS+E+R+QEEARCLVEELRK+K + D T + N+ICSI+F KRFDYKD FL L+ Sbjct: 121 RSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRLL 180 Query: 199 EKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMN 258 + ++ ++SS Q+ FS + YFPGTH ++ +N+ + ++I + V++H+ ++D + Sbjct: 181 DLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPS 240 Query: 259 NPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPE 318 NP+DFID +L++MEK+K + SEF ++L T + LF AGTETTSTTLRY LL+LK+P Sbjct: 241 NPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLKYPH 300 Query: 319 VTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRN 378 VT +VQ+EIE+VIG +R P + DR+ MPYTDAV+HE+QR DL+P +PH VT D +FR Sbjct: 301 VTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRG 360 Query: 379 YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGE 438 Y+IPK T + L+S LHD + F P F+P HFLD G K+++ FMPFS GKRIC+GE Sbjct: 361 YVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRICLGE 420 Query: 439 ALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFI 488 +A ELFLF T+ILQNF++ S V P+++D TP +G +VPP YQ+ F+ Sbjct: 421 GIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNVPPSYQIRFL 470 >3IBD-A nrPDB Length = 476 Score = 541 bits (1393), Expect = e-154, Method: Composition-based stats. Identities = 230/471 (48%), Positives = 334/471 (70%) Query: 19 LWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH 78 + +++S +GKLPPGP PLP++GN+LQ+ + + KS + YG VFT++ G +P+V+L Sbjct: 1 MAKKTSSKGKLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC 60 Query: 79 GYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK 138 G EA++EAL+D E FSGRG + + RG+G++F+NG +WK +RRFS+ T+R+FGMGK Sbjct: 61 GVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK 120 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLM 198 RS+E+R+QEEA+CL+EELRK+K + DPTF+ N+ICSI+F KRF Y+DQ+FL ++ Sbjct: 121 RSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKML 180 Query: 199 EKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMN 258 + ++SS + Q+ FS + +FPG H ++ KN+ + +YI V++H+E++D + Sbjct: 181 NLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPS 240 Query: 259 NPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPE 318 P+D ID +L+ MEKEK N SEF+ ++L + LF AGTETTSTTLRY LL+LK+P Sbjct: 241 APRDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPH 300 Query: 319 VTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRN 378 V +V EIE+VIG +R P + DR+ MPYT+AV++E+QR+ DLLP +PH VT FR Sbjct: 301 VAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRG 360 Query: 379 YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGE 438 Y+IPK T + + L++ LHD F P+ F+P HFLD G KK++ F+PFS GKRIC+GE Sbjct: 361 YIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGE 420 Query: 439 ALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIP 489 +A ELFLF T+ILQNF++ S V P+++D TP G +PP YQ+ F+P Sbjct: 421 GIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLP 471 >2PG7-A nrPDB Length = 476 Score = 540 bits (1391), Expect = e-154, Method: Composition-based stats. Identities = 233/471 (49%), Positives = 331/471 (70%) Query: 19 LWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH 78 + +++S +GKLPPGPTPLP IGN LQ+ + + SL +S+ YGPVFT++ G + +VVL Sbjct: 1 MAKKTSSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLC 60 Query: 79 GYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK 138 G++AV+EAL+D EEFSGRG + +G+G+VFSNG++ K++RRFS+ TLR+FG+GK Sbjct: 61 GHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGK 120 Query: 139 RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLM 198 R IE+R+QEEA L++ LR T + DPTF L NVI SI+F RFDYKD++FL+L+ Sbjct: 121 RGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLL 180 Query: 199 EKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMN 258 + + S+ Q+ FS ++ + PG + + + ++ +I +KV+ +Q ++D N Sbjct: 181 RMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPN 240 Query: 259 NPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPE 318 +P+DFID FL++M++E+ N +EF +++L T + LF GTET STTLRY LLL+KHPE Sbjct: 241 SPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMKHPE 300 Query: 319 VTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRN 378 V AKV EEI+RVIG+NR P +DR+ MPY +AV+HE+QR+ D++P SL V D KFR+ Sbjct: 301 VEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRD 360 Query: 379 YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGE 438 + +PKGT + L SVL D F NP+ F+P HFL+E G FKKS F+PFS GKR C GE Sbjct: 361 FFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGE 420 Query: 439 ALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIP 489 LA MELFLF T+++QNF LKS PK++D +P GFA++P Y + F+P Sbjct: 421 GLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLP 471 >5E0E-A nrPDB Length = 463 Score = 533 bits (1372), Expect = e-152, Method: Composition-based stats. Identities = 230/448 (51%), Positives = 326/448 (72%) Query: 41 NILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIF 100 N+LQ+ S + + YG VFT++ G +P+V+L+G EA++EAL+D E FSGRG Sbjct: 14 NLLQMDRGGFLNSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI 73 Query: 101 PLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK 160 + E RG+G+VF+NG++WK +RRFSL+T+R+FGMGKRS+E+R+QEEARCLVEE RK++ Sbjct: 74 AVVEPIFRGYGVVFANGERWKALRRFSLVTMRDFGMGKRSVEERIQEEARCLVEEFRKSQ 133 Query: 161 ASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFS 220 +P DPTF+ C N+ICSI+F +RFDYKD QFL L+ ++ ++SS Q+ FS Sbjct: 134 GAPLDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFS 193 Query: 221 PIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPS 280 + YFPGTH ++ +N+ + YI + V++H+ ++D ++P+DFID +L++MEKEK NQ + Sbjct: 194 GFLKYFPGTHRQISRNLQEILDYIGQSVEKHRATLDPSHPRDFIDTYLLRMEKEKSNQHT 253 Query: 281 EFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQ 340 EF ++L + + LF AGTET+STTLRY LL+LK+P V KVQ+EI++VIG +R P ++ Sbjct: 254 EFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLE 313 Query: 341 DRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKE 400 DR+ MPYT+AV++E+QR+ DL+P +PH VT D FR YL+PK T + L+S LHD + Sbjct: 314 DRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQY 373 Query: 401 FPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKS 460 F P+ F+P HFLD G KKS+ FMPFS GKRIC+GE +A ELFLF T+ILQNF+L S Sbjct: 374 FEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSLSS 433 Query: 461 LVDPKNLDTTPVVNGFASVPPFYQLCFI 488 V PK++D +P +GF VP YQ+CF+ Sbjct: 434 PVAPKDIDLSPKESGFGKVPQTYQICFL 461 >5E58-A nrPDB Length = 493 Score = 526 bits (1355), Expect = e-150, Method: Composition-based stats. Identities = 225/448 (50%), Positives = 318/448 (70%) Query: 41 NILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIF 100 N+LQ+ S + + YG VFT++ G +P+V+L+G EA++EAL+D E FSGRG Sbjct: 42 NLLQMDRGGFLNSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI 101 Query: 101 PLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK 160 + + +G++FSNG++WK +RRFSL T+R+FGMGKRS+EDR+QEEA+CLVEEL+K++ Sbjct: 102 AVIKPVIGDYGMIFSNGERWKVLRRFSLATMRDFGMGKRSVEDRIQEEAQCLVEELQKSQ 161 Query: 161 ASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFS 220 +P DPTF+ C N+ICSI+F +R+DYKD+QFL L++ ++SS Q+ FS Sbjct: 162 GAPLDPTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFS 221 Query: 221 PIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPS 280 + YFPG H ++ +N+ + Y+ + V++H+ ++D +NP+DFID +L++MEKEK NQ + Sbjct: 222 GFMKYFPGAHRQITRNLQEILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEKSNQHT 281 Query: 281 EFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQ 340 EF ++L + + LF AGTETTSTTLRY LL+LK+P V KVQ+EI++VIG +R P ++ Sbjct: 282 EFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLE 341 Query: 341 DRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKE 400 DR+ MPYTDAV+HE+QR+ DL P PH VT D FR YL+PK T + L+S LHD + Sbjct: 342 DRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQY 401 Query: 401 FPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKS 460 F P F+P HFLD G KKS+ FMPFS GKRIC+GE +A ELFLF T+ILQNF++ S Sbjct: 402 FEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSVSS 461 Query: 461 LVDPKNLDTTPVVNGFASVPPFYQLCFI 488 V PK++D +P +G VP YQ+ F+ Sbjct: 462 SVAPKDIDLSPKESGIGKVPQTYQISFL 489 >6B82-A nrPDB Length = 509 Score = 438 bits (1127), Expect = e-123, Method: Composition-based stats. Identities = 147/490 (30%), Positives = 250/490 (51%), Gaps = 27/490 (5%) Query: 19 LWRQSSGRGK-------------LPPGPTPLPVIGNILQI-GIKDISKSLTNLSKVYGPV 64 + +++S +GK PP LP+IG+++ + +L K YG + Sbjct: 1 MAKKTSSKGKKQKMNGFVPAGNRSPPSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDL 60 Query: 65 FTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANR-GFGIVFSN-GKKWKE 122 ++L G +++++ + KE LI G+ F+GR + R G I F++ WK Sbjct: 61 YSLMMGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKF 120 Query: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSII 182 R+ L FG G SIE + EA + E L +++ S D L A NV+C++ Sbjct: 121 HRKMVHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALC 180 Query: 183 FHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKS 242 F+ + D +F ++++ + ++ + + P + FP ++L+ ++ Sbjct: 181 FNSSYKRGDAEFESMLQYSQGIVDTVAKDSLV---DIFPWLQIFPNKDLRILRQCISIRD 237 Query: 243 YILEK-VKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSE----FTIESLENTAVDLFGA 297 +L+K +EH+ + N +D +D L ++N S T + + T ++FGA Sbjct: 238 KLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGA 297 Query: 298 GTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQR 357 G ETT+TTL++++ L+ +P+V K+QEE++ IG+ R P + DR ++PY +A + EV R Sbjct: 298 GVETTTTTLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMR 357 Query: 358 YIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGG 417 + P +PH D Y + KGT ++I++ S+ HD KE+ NPE+FDP FL+E G Sbjct: 358 IRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEG 417 Query: 418 NFK--KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNG 475 + S ++PF AG R+C+GEALA MELFLFL ILQ F L+ + L G Sbjct: 418 DGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEM-PTGQPLPDLQGKFG 476 Query: 476 FASVPPFYQL 485 P +++ Sbjct: 477 VVLQPKKFKV 486 >3TBG-A nrPDB Length = 479 Score = 431 bits (1109), Expect = e-121, Method: Composition-based stats. Identities = 194/476 (40%), Positives = 284/476 (59%), Gaps = 7/476 (1%) Query: 19 LWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH 78 + +++S +GKLPPGP PLP +GN+L + ++ L + +G VF+L P+VVL+ Sbjct: 1 MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN 60 Query: 79 GYEAVKEALIDLGEEFSGRGIFPLAE---RANRGFGIVFSN-GKKWKEIRRFSLMTLRNF 134 G AV+EAL+ GE+ + R P+ + R G+ + G W+E RRFS+ TLRN Sbjct: 61 GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL 120 Query: 135 GMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQF 194 G+GK+S+E V EEA CL P P +L A NVI S+ +RF+Y D +F Sbjct: 121 GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF 180 Query: 195 LNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQES 254 L L++ E +K S +++ N P++ + P K+L+ + + E + EH+ + Sbjct: 181 LRLLDLAQEGLKE-ESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMT 239 Query: 255 MDM-NNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLL 313 D P+D + FL +MEK K N S F E+L DLF AG TTSTTL + LLL+ Sbjct: 240 WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM 299 Query: 314 LKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCD 373 + HP+V +VQ+EI+ VIG+ R P M D++HMPYT AV+HEVQR+ D++P + H + D Sbjct: 300 ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRD 359 Query: 374 IKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKR 433 I+ + + IPKGTT++ +L+SVL D + P F P HFLD G+F K + F+PFSAG+R Sbjct: 360 IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR 419 Query: 434 ICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIP 489 C+GE LA MELFLF TS+LQ+F+ S+ + + V F P Y+LC +P Sbjct: 420 ACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFLVSPSPYELCAVP 474 >6DWN-A nrPDB Length = 491 Score = 427 bits (1099), Expect = e-120, Method: Composition-based stats. Identities = 148/471 (31%), Positives = 253/471 (53%), Gaps = 22/471 (4%) Query: 19 LWRQSSGRG-KLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVL 77 + +++S +G K PPGP P+IG++L +G K+ +L+ +S+ YG V + G P+VVL Sbjct: 1 MAKKTSSKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVL 59 Query: 78 HGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFS--NGKKWKEIRRFSLMTLRNFG 135 G + +++AL+ G++F GR + G + FS +G W RR + L++F Sbjct: 60 SGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFS 119 Query: 136 MGKRS-------IEDRVQEEARCLVEELRKTKASP--CDPTFILGCAPCNVICSIIFHKR 186 + +E+ V +EA L+ L++ A P +P + + NVIC+I F +R Sbjct: 120 IASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRR 179 Query: 187 FDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILE 246 +D+ Q+ L+L+ N +++ S +F PI+ Y P K++ ++ Sbjct: 180 YDHNHQELLSLVNLNNNFGEVVGSG---NPADFIPILRYLPNPSLNAFKDLNEKFYSFMQ 236 Query: 247 K-VKEHQESMDMNNPQDFIDCFLMKMEKE--KHNQPSEFTIESLENTAVDLFGAGTETTS 303 K VKEH ++ + + +D D + +++ N + + E + N +DLFGAG +T + Sbjct: 237 KMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVT 296 Query: 304 TTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP 363 T + ++L+ L+ +P V K+QEE++ VIGR+R P + DRSH+PY +A + E R+ +P Sbjct: 297 TAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVP 356 Query: 364 TSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKK-- 421 ++PH+ T D + + IPKG + ++ + HD K + NP F P FL G K Sbjct: 357 FTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVL 416 Query: 422 SKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPV 472 S+ + F GKR C+GE +A E+FLFL +LQ S+ +D TP+ Sbjct: 417 SEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF-SVPLGVKVDMTPI 466 >3DL9-A nrPDB Length = 479 Score = 414 bits (1063), Expect = e-116, Method: Composition-based stats. Identities = 158/442 (35%), Positives = 253/442 (57%), Gaps = 9/442 (2%) Query: 50 ISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRG 109 + S+VYG +F+L G VVL+GY+ VKE L+ E F+ R PL + + Sbjct: 36 PHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKM 95 Query: 110 FGIVFSN-GKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTF 168 G++ S G+ W + RR ++ + R FG G++S E ++ EE + + + K P D Sbjct: 96 GGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQ 155 Query: 169 ILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFP- 227 ++ A N+ IIF +RF Y+D F +++E +EN+++ +S + + N F P I P Sbjct: 156 LITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAF-PWIGILPF 214 Query: 228 GTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESL 287 G H +L +N A + ++ +++ + PQ F+D +L +M++ K++ S F+ E+L Sbjct: 215 GKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENL 274 Query: 288 ENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPY 347 + +L AGTETT+ LR+A+L + +P + +VQ+EI+ ++G N P D+ MPY Sbjct: 275 IFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPY 334 Query: 348 TDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMF 407 T+AV+HEV R+ +++P + HA + D R Y IPKGTT++ +L SV D K + +PE+F Sbjct: 335 TEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVF 394 Query: 408 DPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNL 467 P FLD G F K + +PFS G+R C+GE LA ME+FLF T++LQ F+ L P L Sbjct: 395 HPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFH---LHFPHEL 451 Query: 468 --DTTPVVNGFASVPPFYQLCF 487 D P + G P Y +C Sbjct: 452 VPDLKPRL-GMTLQPQPYLICA 472 >4R20-A nrPDB Length = 486 Score = 408 bits (1049), Expect = e-114, Method: Composition-based stats. Identities = 148/483 (30%), Positives = 240/483 (49%), Gaps = 17/483 (3%) Query: 19 LWRQSSGRGKLPPGPTP--LPVIGNILQIGIK-------DISKSLTNLSKVYGPVFTLYF 69 + +++S +GK G + P + + +G T LS YGP+F LY Sbjct: 1 MAKKTSSKGKEGVGSSSVSFPCLPRLPLLGSLLHLRSNLPPHLLFTQLSSQYGPLFGLYA 60 Query: 70 GLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRG-FGIVFSN-GKKWKEIRRFS 127 G +V+ V+E L+ G EF+GR + +G I F++ WK RR Sbjct: 61 GPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQGGKDIAFADYSPLWKNHRRLV 120 Query: 128 LMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRF 187 + FG G ++ VQE A L EEL+ + D + +L A NVIC ++F + Sbjct: 121 HSSFTLFGEGSNKLQTIVQEAADSLCEELQACRGQSSDLSVVLMRAVTNVICRLVFSSSY 180 Query: 188 DYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYIL-E 246 D + +++ + ++ ++ + + P + FP K LK ++ +L + Sbjct: 181 QPSDPELQTVIQYNDGIVQTIARGGLV---DIFPWLRIFPNKDLKRLKECVSIRDQLLYK 237 Query: 247 KVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTL 306 K+ EH++S+ P+D +D L+ ++ + T + + TA + FGAG ETTSTTL Sbjct: 238 KLLEHKKSLTPGEPRDLLDALLIGQQRGSGGA-DDITEDHVLMTAAEAFGAGVETTSTTL 296 Query: 307 RYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSL 366 + + LL HP++ +VQ E++ +G +R PC+ DR H+P DAV+ EV R + P + Sbjct: 297 LWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSDRPHLPLLDAVLCEVMRIRPVSPILI 356 Query: 367 PHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFM 426 PH D + +PKGT +L+++ ++ HD K + PE F+P FL+ G K F+ Sbjct: 357 PHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWDQPEQFNPERFLEPSGKKKTQSSFL 416 Query: 427 PFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLC 486 PF AG R+CVGE+LA +ELFLF++ LQ F+ S +L G P Y + Sbjct: 417 PFGAGPRVCVGESLARIELFLFVSRPLQRFSF-SCPSEASLPDLQGRFGVVLQPERYTVT 475 Query: 487 FIP 489 P Sbjct: 476 VTP 478 >2HI4-A nrPDB Length = 495 Score = 402 bits (1033), Expect = e-112, Method: Composition-based stats. Identities = 138/460 (30%), Positives = 229/460 (49%), Gaps = 20/460 (4%) Query: 28 KLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEAL 87 K PP P P++G++L +G K+ +L+ +S+ YG V + G P++VL + +++AL Sbjct: 16 KSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL 74 Query: 88 IDLGEEFSGRGIFPLAERANRGFGIVFS--NGKKWKEIRRFSLMTLRNFGMGKRS----- 140 + G++F GR + G + FS +G W RR + L F + Sbjct: 75 VRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS 134 Query: 141 --IEDRVQEEARCLVEELRKTKASP--CDPTFILGCAPCNVICSIIFHKRFDYKDQQFLN 196 +E+ V +EA+ L+ L++ A P DP + + NVI ++ F + F + L+ Sbjct: 135 CYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS 194 Query: 197 LMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEK-VKEHQESM 255 L++ +E ++ SS +F PI+ Y P + K + L+K V+EH + Sbjct: 195 LVKNTHEFVETASSG---NPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDF 251 Query: 256 DMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLK 315 D N+ +D +K + E + N D+FGAG +T +T + ++L+ L+ Sbjct: 252 DKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVT 311 Query: 316 HPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIK 375 PE+ K+Q+E++ VIGR R P + DR +PY +A + E R+ LP ++PH+ T D Sbjct: 312 KPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTT 371 Query: 376 FRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGG---NFKKSKYFMPFSAGK 432 + IPK + ++ V HD + + +P F P FL G N S+ M F GK Sbjct: 372 LNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGK 431 Query: 433 RICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPV 472 R C+GE LA E+FLFL +LQ S+ +D TP+ Sbjct: 432 RRCIGEVLAKWEIFLFLAILLQQLEF-SVPPGVKVDLTPI 470 >5UYS-A nrPDB Length = 494 Score = 389 bits (999), Expect = e-108, Method: Composition-based stats. Identities = 130/469 (27%), Positives = 233/469 (49%), Gaps = 19/469 (4%) Query: 19 LWRQSSGRGKLPPGPTPLPVIGNILQIGIKD-ISKSLTNLSKVYGPVFTLYFGLKPIVVL 77 + +++ K P LP++G++ + + + L K YGP++++ G K V++ Sbjct: 1 MAKKTGA--KYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIV 58 Query: 78 HGYEAVKEALIDLGEEFSGRGIFPLAERA-NRGFGIVFSN-GKKWKEIRRFSLMTLRNFG 135 ++ KE LI G++FSGR + A N GI F++ G W+ RR ++ T F Sbjct: 59 GHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFK 118 Query: 136 MGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFL 195 G + +E + +E L + L D +F + A NVI I F+ + D + L Sbjct: 119 DGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPE-L 177 Query: 196 NLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKE-HQES 254 N+++ NE I+ + + P + FP + LK+ +++ +L K+ E ++E Sbjct: 178 NVIQNYNEG--IIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEK 235 Query: 255 MDMNNPQDFIDCFLMKMEKEKHNQPSE------FTIESLENTAVDLFGAGTETTSTTLRY 308 ++ + +D + + + + T D+FGAG ETT++ +++ Sbjct: 236 FRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKW 295 Query: 309 ALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPH 368 L LL +P+V K+ EEI++ +G +R+P + DR+ + +A + EV R + P +PH Sbjct: 296 TLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPH 355 Query: 369 AVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGN--FKKSKYFM 426 D + + KGT ++I+L ++ H+ KE+ P+ F P FL+ G S ++ Sbjct: 356 KANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYL 415 Query: 427 PFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPK--NLDTTPVV 473 PF AG R C+GE LA ELFL + +LQ F+L+ D + +L+ P V Sbjct: 416 PFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKV 464 >4R1Z-A nrPDB Length = 439 Score = 384 bits (987), Expect = e-107, Method: Composition-based stats. Identities = 134/426 (31%), Positives = 220/426 (51%), Gaps = 13/426 (3%) Query: 69 FGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANR-GFGIVFSN-GKKWKEIRRF 126 G +++++ + KE LI G+ F+GR + R G I F++ WK R+ Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKM 60 Query: 127 SLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKR 186 L FG G SIE + EA + E L +++ S D L A NV+C++ F+ Sbjct: 61 VHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSS 120 Query: 187 FDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILE 246 + D +F ++++ + ++ + + P + FP +L+ ++ +L+ Sbjct: 121 YKRGDAEFESMLQYSQGIVDTVAKDSLV---DIFPWLQIFPNKDLTILRQCISIRDKLLQ 177 Query: 247 K-VKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSE----FTIESLENTAVDLFGAGTET 301 K +EH+ + N +D +D L ++N S T + + T D+FGAG ET Sbjct: 178 KKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDIFGAGVET 237 Query: 302 TSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDL 361 T+T L++++ L+ +P+V K+QEE++ IG+ R P + DR ++PY +A + EV R + Sbjct: 238 TTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIREVLRIRPV 297 Query: 362 LPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK- 420 P +PH D Y + KGT ++I+L S+ HD KE+ NPE+FDP FL+E G+ Sbjct: 298 SPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLNEEGDGLC 357 Query: 421 -KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASV 479 S ++PF AG R+C+GEALA MELFLFL ILQ F L+ + L G Sbjct: 358 CPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEM-PTGQPLPDLQGKFGVVLQ 416 Query: 480 PPFYQL 485 P +++ Sbjct: 417 PKKFKV 422 >5VBU-A nrPDB Length = 476 Score = 372 bits (954), Expect = e-103, Method: Composition-based stats. Identities = 135/483 (27%), Positives = 234/483 (48%), Gaps = 31/483 (6%) Query: 19 LWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH 78 + +++S +GKLPP + L + D+ L L++ +GP++ L+ GL+ +VVL+ Sbjct: 1 MAKKTSSKGKLPP------LAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDVVVLN 54 Query: 79 GYEAVKEALIDLGEEFSGRGIFPLAERANRGF-----GIVFSNGKKWKEIRRFSLMTLRN 133 ++EA++ +F+GR + +R + G K K++ R +L+ Sbjct: 55 SKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALL---- 110 Query: 134 FGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQ 193 G+ + S+E V++ + E +R +P C++IC + F + KD Sbjct: 111 LGI-RDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKI--KDDN 167 Query: 194 FLNLMEK-LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEK-VKEH 251 + K + E +K S IQI + P + +FP + LK + +I+E +++H Sbjct: 168 LMPAYYKCIQEVLKTWSHWSIQIVDVI-PFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQH 226 Query: 252 QESMDMNNPQDFIDCFLMKMEKEKHNQPS-EFTIESLENTAVDLFGAGTETTSTTLRYAL 310 +ES+ +D +D L + + + S + + AVDL GTETT+ TL +A+ Sbjct: 227 KESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAV 286 Query: 311 LLLLKHPEVTAKVQEEIERVIGRNRS---PCMQDRSHMPYTDAVVHEVQRYIDLLPTSLP 367 + LL HPE+ ++QEE++ +G S +DR+ +P +A + EV R ++P +LP Sbjct: 287 VFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALP 346 Query: 368 HAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMP 427 H T Y IP+GT I+ +L D + P F P FL+ G N + + Sbjct: 347 HRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRA----LA 402 Query: 428 FSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDP-KNLDTTPVVNGFASVPPFYQLC 486 F G R+C+GE LA +ELF+ LT +LQ F L D +L P + + P +Q+ Sbjct: 403 FGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQP-FQVR 461 Query: 487 FIP 489 P Sbjct: 462 LQP 464 >6IQ5-A nrPDB Length = 463 Score = 364 bits (934), Expect = e-101, Method: Composition-based stats. Identities = 141/453 (31%), Positives = 231/453 (50%), Gaps = 23/453 (5%) Query: 51 SKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGF 110 S L++ YG VF + G PIVVL+G A+ +AL+ G F+ R F + G Sbjct: 4 HLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVSGGR 63 Query: 111 GIVFSN-GKKWKEIRRFSLMTLRNF----GMGKRSIEDRVQEEARCLVEELRKTKASPC- 164 + F + + WK RR + +RNF ++ +E V EAR LV L + A Sbjct: 64 SMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAF 123 Query: 165 -DPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPII 223 DP + A NV+ ++ F R+ + D +F L+ E + + + + + P + Sbjct: 124 LDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLV---DVMPWL 180 Query: 224 DYFPGTHNKLLKNVAFM----KSYILEKVKEHQESMDMNN-PQDFIDCFLMKMEK----E 274 YFP + + + ++IL+K H ES+ P+D +D F++ EK + Sbjct: 181 QYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGD 240 Query: 275 KHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRN 334 H + +E++ T D+FGA +T ST L++ LLL ++P+V +VQ E+++V+GR+ Sbjct: 241 SHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRD 300 Query: 335 RSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSV 394 R PCM D+ ++PY A ++E R+ +P ++PHA T + Y IPK T + ++ SV Sbjct: 301 RLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSV 360 Query: 395 LHDNKEFPNPEMFDPHHFLDEGGNFKK--SKYFMPFSAGKRICVGEALAGMELFLFLTSI 452 HD ++PNPE FDP FLD+ G K + M FS GKR C+GE L+ M+LFLF++ + Sbjct: 361 NHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISIL 420 Query: 453 LQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQL 485 + + +P G P +++ Sbjct: 421 AHQCDFR--ANPNEPAKMNFSYGLTIKPKSFKV 451 >3QZ1-A nrPDB Length = 496 Score = 356 bits (914), Expect = 1e-98, Method: Composition-based stats. Identities = 127/465 (27%), Positives = 217/465 (46%), Gaps = 26/465 (5%) Query: 37 PVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSG 96 P++ L + ++ L +L++ GPV+ L GL+ +VVL+ ++EA+I +F+G Sbjct: 32 PLVPGFLHLLQPNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAG 91 Query: 97 RGIFPLAERANR-----GFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARC 151 R P + ++ G K K++ R +L+ + S+E V + + Sbjct: 92 RPQIPSYKLVSQRCQDISLGDYSLLWKAHKKLTRSALLLGT-----RSSMEPWVDQLTQE 146 Query: 152 LVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSP 211 E +R +P C++IC + F + D F + ++ L +K Sbjct: 147 FCERMRVQAGAPVTIQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQDL---MKTWDHW 203 Query: 212 WIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEK-VKEHQESMDMNNPQDFIDCFLMK 270 IQI + P + +FP LK + +++EK ++ H+ESM +D D L Sbjct: 204 SIQILD-MVPFLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDMTDYMLQG 262 Query: 271 MEKEK-HNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIER 329 + +++ P + + + VDLF GTETT++TL +A+ LL HPE+ ++QEE++R Sbjct: 263 VGRQRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEELDR 322 Query: 330 VIGRNRS---PCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTT 386 +G S +DR+ +P +A + EV R ++P +LPH T Y IP+G Sbjct: 323 ELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGMV 382 Query: 387 ILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELF 446 ++ +L D + P F P FL+ G N + F G R+C+GE+LA +ELF Sbjct: 383 VIPNLQGAHLDETVWEQPHEFRPDRFLEPGANPSA----LAFGCGARVCLGESLARLELF 438 Query: 447 LFLTSILQNFNLKSLVDP--KNLDTTPVVNGFASVPPFYQLCFIP 489 + L +LQ F L +L P V P +Q+ P Sbjct: 439 VVLARLLQAFTLLPPPVGALPSLQPDPYCGVNLKVQP-FQVRLQP 482 >5YLW-A nrPDB Length = 495 Score = 342 bits (877), Expect = 2e-94, Method: Composition-based stats. Identities = 120/479 (25%), Positives = 219/479 (45%), Gaps = 36/479 (7%) Query: 1 MDS---LVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNL 57 MDS L L + + LS R R LPPGP P P++GN+LQ+G + + L Sbjct: 1 MDSFPLLAALFFIAATITFLSFRR----RRNLPPGPFPYPIVGNMLQLG-ANPHQVFAKL 55 Query: 58 SKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLA-----ERANRGFGI 112 SK YGP+ +++ G V++ E KE L G+ FSGR I ++ + GF Sbjct: 56 SKRYGPLMSIHLGSLYTVIVSSPEMAKEILHRHGQVFSGRTIAQAVHACDHDKISMGFLP 115 Query: 113 VFSNGKKWKEIRR---FSLMTL-RNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTF 168 V S + ++I + FS ++ + G+ ++ ++ + +C D Sbjct: 116 VASEWRDMRKICKEQMFSNQSMEASQGLRRQKLQQLLDHVQKC------SDSGRAVDIRE 169 Query: 169 ILGCAPCNVICSIIFHKRF-DYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFP 227 N++ + +F + ++ + + E + I+ P + F + + P Sbjct: 170 AAFITTLNLMSATLFSSQATEFDSKATMEFKEIIEGVATIVGVPNF--ADYFPILRPFDP 227 Query: 228 GTHNKLL-----KNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEF 282 + K +A ++ Y+ E+++ + + + DF++ + ++ + Sbjct: 228 QGVKRRADVFFGKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDIIQANEFK----L 283 Query: 283 TIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDR 342 + +DLF G++T +T++ +A+ L+ +P+ A+++ E++ V G + Sbjct: 284 KTHHFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKIVDESAM 343 Query: 343 SHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFP 402 +PY AV+ EV R P LP D + YLIPKGT ILI+ ++ D + Sbjct: 344 PKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRDPSIWT 403 Query: 403 NPEMFDPHHFLDEGGNFKKSKY-FMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKS 460 +PE FDP FLD +FK Y +PF +G+R+C G LA L + +++ NF+ K Sbjct: 404 DPETFDPERFLDNKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNFDWKL 462 >6DA2-A nrPDB Length = 487 Score = 334 bits (857), Expect = 5e-92, Method: Composition-based stats. Identities = 121/447 (27%), Positives = 184/447 (41%), Gaps = 29/447 (6%) Query: 31 PGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID- 89 PGPTPLP +GNIL K K YG V+ Y G +P++ + + +K L+ Sbjct: 19 PGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 77 Query: 90 LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK-RSIEDRVQEE 148 F+ R P I + ++WK +R + F GK + + + + Sbjct: 78 CYSVFTNRR--PFGPVGFMKSAISIAEDEEWKRLRS---LLSPTFTSGKLKEMVPIIAQY 132 Query: 149 ARCLVEELRKTK--ASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNE--N 204 LV LR+ P + G +VI S F D + +E + Sbjct: 133 GDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR 192 Query: 205 IKILSSPWIQI--CNNFSPIIDY-----FPGT-HNKLLKNVAFMKSYILEKVKEHQESMD 256 L ++ I PI++ FP N L K+V MK LE ++H+ Sbjct: 193 FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHR---- 248 Query: 257 MNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKH 316 ++ Q ID K E E H S+ L ++ AG ETTS+ L + + L H Sbjct: 249 VDFLQLMIDSQNSK-ETESHKALSDL---ELVAQSIIFIFAGYETTSSVLSFIMYELATH 304 Query: 317 PEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKF 376 P+V K+QEEI+ V+ P M Y D VV+E R + L D++ Sbjct: 305 PDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEI 363 Query: 377 RNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICV 436 IPKG ++I ++ D K + PE F P F + + + PF +G R C+ Sbjct: 364 NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCI 423 Query: 437 GEALAGMELFLFLTSILQNFNLKSLVD 463 G A M + L L +LQNF+ K + Sbjct: 424 GMRFALMNMKLALIRVLQNFSFKPCKE 450 >5VEU-A nrPDB Length = 480 Score = 325 bits (833), Expect = 3e-89, Method: Composition-based stats. Identities = 123/456 (26%), Positives = 189/456 (41%), Gaps = 33/456 (7%) Query: 31 PGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID- 89 PGPTPLP++GN+L + + K T K YG ++ Y G P++ + + ++ L+ Sbjct: 18 PGPTPLPLLGNVLSY-RQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 76 Query: 90 LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK-RSIEDRVQEE 148 F+ R L I + ++WK IR + F GK + + + + Sbjct: 77 CYSVFTNRR--SLGPVGFMKSAISLAEDEEWKRIRS---LLSPTFTSGKLKEMFPIIAQY 131 Query: 149 ARCLVEELRKT--KASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIK 206 LV LR+ K P I G +VI F D + +E + +K Sbjct: 132 GDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK 191 Query: 207 ILSSPWIQICNNFSPII---------DYFPGTH-NKLLKNVAFMKSYILEKVKEHQESMD 256 + + P + FP N L K+V MK L ++H+ Sbjct: 192 FGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHR---- 247 Query: 257 MNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKH 316 ++ Q ID K E E H S+ L ++ AG ETTS+ L + L L H Sbjct: 248 LDFLQLMIDSQNSK-ETESHKALSDL---ELAAQSIIFIFAGYETTSSVLSFTLYELATH 303 Query: 317 PEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKF 376 P+V K+Q+EI+ V+ P M Y D VV+E R + L D++ Sbjct: 304 PDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA-IRLERTCKKDVEI 362 Query: 377 RNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICV 436 IPKG+ ++I ++ HD K + PE F P F + + + PF G R C+ Sbjct: 363 NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSI-DPYIYTPFGTGPRNCI 421 Query: 437 GEALAGMELFLFLTSILQNFNLKSLVD---PKNLDT 469 G A M + L L +LQNF+ K + P LDT Sbjct: 422 GMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDT 457 >6AYB-A nrPDB Length = 466 Score = 325 bits (832), Expect = 4e-89, Method: Composition-based stats. Identities = 104/477 (21%), Positives = 199/477 (41%), Gaps = 40/477 (8%) Query: 19 LWRQSSGRGKLPPG-PTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVL 77 + +++S +GKLPP P +P +G+ + K+ + + + SK YG VFT K + L Sbjct: 1 MAKKTSSKGKLPPRVPNLIPYVGSFVSFA-KNPVQFIIDNSKKYGDVFTATILGKEMTFL 59 Query: 78 HGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNG--KKWKEIRRF--SLMTLRN 133 + + + E S R ++ G G+V+ ++ E +F S +T Sbjct: 60 NHPKILDTFFKATDNELSLRDVYRFMRPVF-GTGVVYDADSTERMMEQVKFVSSGLTTAR 118 Query: 134 FGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQ 193 F + ED + + + L E A I + C + + +Q Sbjct: 119 FRVFVDIFEDEIAHKVKELGPEGTVDVAELMADLIIFTASRCLLGDEV----------RQ 168 Query: 194 FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPG----THNKLLKNVAFMKSYILEKVK 249 +L+ K L + I + SP+ ++P +K K V + +L+K + Sbjct: 169 YLSE--------KNLGKLYHDIDDGISPLSFFYPSLPAPKRDKARKAVGEIFQELLDKRR 220 Query: 250 E----HQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTT 305 E H E + + D +D L +K+ E T + AG T+S T Sbjct: 221 EEHKKHPERLLDESKMDVVDHLLT----QKYKDGQELTDVHRIGILIAGLFAGQHTSSIT 276 Query: 306 LRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTS 365 + L+ ++ + +V KV++E E ++G ++ M Y +A + E R L Sbjct: 277 SSWTLMNVISNKKVLEKVRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPPL-IM 335 Query: 366 LPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYF 425 + + Y+IPKG +++S + + NP++FDP + + K Sbjct: 336 IMRMARKPRECEQYIIPKGNILVVSPSVAGRCTDTYTNPDVFDPERLTERKEHEKFKYGA 395 Query: 426 MPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPF 482 +PF AG+ C+GE A +++ ++ +L+ F+++ + + T +V G + PP Sbjct: 396 VPFGAGRHKCIGENFALLQVKSIISILLRYFDMEYIGKIPDPSYTSLVVGPS--PPT 450 >2WX2-A nrPDB Length = 473 Score = 316 bits (809), Expect = 2e-86, Method: Composition-based stats. Identities = 91/458 (19%), Positives = 178/458 (38%), Gaps = 37/458 (8%) Query: 30 PPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID 89 P P +P +G+I+Q G + + VFT+ G + + ++ Sbjct: 19 PVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSRFFSP 78 Query: 90 LGEEFSGRGIFPLAERANRGFGIVFSN-GKKWKEIRRF--SLMTLRNFGMGKRSIEDRVQ 146 E S R ++ + G G+ ++ + +E F +T+ F ++ +Q Sbjct: 79 RNEILSPREVYTIMTPVF-GEGVAYAAPYPRMREQLNFLAEELTIAKF----QNFVPAIQ 133 Query: 147 EEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHK--RFDYKDQQFLNLMEKLNEN 204 E R + E K + G N C +F + R + F L+ K+ + Sbjct: 134 HEVRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSKMESS 193 Query: 205 IKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKV---KEHQESMDMNNPQ 261 + + F P + P + + IL ++ +E +E+ NN Sbjct: 194 LIPAAV--------FMPWLLRLPLPQSARCREARAELQKILGEIIVAREKEEASKDNNTS 245 Query: 262 DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLK--HPEV 319 D + L + + + ++ + V AG T++ T +++L L+ + + Sbjct: 246 DLLGGLLKAVYR----DGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKW 301 Query: 320 TAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNY 379 K+ +EI+ + + D MP+ + V E R L + V ++K +Y Sbjct: 302 LDKLHKEIDEFPAQLNYDNVMD--EMPFAERCVRESIRRDPPL-LMVMRMVKAEVKVGSY 358 Query: 380 LIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEA 439 ++PKG I S HD + FPNP ++DP + K F+ F AG C+G+ Sbjct: 359 VVPKGDIIACSPLLSHHDEEAFPNPRLWDPER------DEKVDGAFIGFGAGVHKCIGQK 412 Query: 440 LAGMELFLFLTSILQNFNLKSLVDP-KNLDTTPVVNGF 476 A +++ L + + ++ + L D + D +V G Sbjct: 413 FALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVGP 450 >3L4D-A nrPDB Length = 453 Score = 311 bits (796), Expect = 5e-85, Method: Composition-based stats. Identities = 94/466 (20%), Positives = 176/466 (37%), Gaps = 41/466 (8%) Query: 26 RGKLPP---GPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEA 82 +GKLPP G T P +G+I+Q G KD + K YG +FT+ I V+ Sbjct: 1 KGKLPPVVHGTT--PFVGHIIQFG-KDPLGFMLKAKKKYGGIFTMNICGNRITVVGDVHQ 57 Query: 83 VKEALIDLGEEFSGRGIFPLAERANRGFGIVFSN-GKKWKEIRRF--SLMTLRNFGMGKR 139 + E S R ++ G G+ ++ + +E F +T+ F + Sbjct: 58 HSKFFTPRNEILSPREVYSFMVPVF-GEGVAYAAPYPRMREQLNFLAEELTVAKF----Q 112 Query: 140 SIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHK--RFDYKDQQFLNL 197 + +Q E R ++ + N C +F + R +QF L Sbjct: 113 NFAPSIQHEVRKFMKANWNKDEGEINILDDCSAMIINTACQCLFGEDLRKRLDARQFAQL 172 Query: 198 MEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKV---KEHQES 254 + K+ + + F P I P + ++ IL ++ +E +E+ Sbjct: 173 LAKMESCLIPAAV--------FLPWILKLPLPQSYRCRDARAELQDILSEIIIAREKEEA 224 Query: 255 MDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLL 314 N D + L + + + + + V AG T++ T ++LL L+ Sbjct: 225 QKDTNTSDLLAGLLGAVYR----DGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLM 280 Query: 315 --KHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTC 372 ++ AK+ +EI+ + + MP+ + E R L L V Sbjct: 281 DPRNKRHLAKLHQEIDEFPAQLNYDNV--MEEMPFAEQCARESIRRDPPL-VMLMRKVLK 337 Query: 373 DIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGK 432 ++ Y++P+G I S D + FPNP ++P + F F AG Sbjct: 338 PVQVGKYVVPEGDIIACSPLLSHQDEEAFPNPREWNPERNMKLVD-----GAFCGFGAGV 392 Query: 433 RICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFAS 478 C+GE +++ L ++L++++ + L + +V G + Sbjct: 393 HKCIGEKFGLLQVKTVLATVLRDYDFELLGPLPEPNYHTMVVGPTA 438 >3JUS-A nrPDB Length = 461 Score = 309 bits (791), Expect = 2e-84, Method: Composition-based stats. Identities = 83/453 (18%), Positives = 160/453 (35%), Gaps = 38/453 (8%) Query: 19 LWRQSSGRG-KLPPGPT-PLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVV 76 + +++ G K PP P+P +G+ + G I + L N + YGPVF+ K Sbjct: 1 MAKKTLPAGVKSPPYIFSPIPFLGHAIAFGKSPI-EFLENAYEKYGPVFSFTMVGKTFTY 59 Query: 77 LHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNG-KKWKEIRRF--SLMTLRN 133 L G +A E+ + ++ G G+ + + E ++ S + + + Sbjct: 60 LLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAH 119 Query: 134 FGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQ 193 F IE +E E K IL + C Sbjct: 120 FKQHVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHC------------------ 161 Query: 194 FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGT-----HNKLLKNVAFMKSYILEKV 248 L+ E ++ + ++ + + FS PG + + +K + + Sbjct: 162 -LHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAI 220 Query: 249 KEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRY 308 ++ ++S Q+ ID L + + T + + + L AG T+STT + Sbjct: 221 QKRRQS------QEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAW 274 Query: 309 ALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQD-RSHMPYTDAVVHEVQRYIDLLPTSLP 367 L + + K E + V G N P D + D + E R + + Sbjct: 275 MGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPI-MIMM 333 Query: 368 HAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMP 427 Y IP G + +S T + F+P +L + + ++P Sbjct: 334 RMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVP 393 Query: 428 FSAGKRICVGEALAGMELFLFLTSILQNFNLKS 460 F AG+ C+GE A +++ +++L+ + Sbjct: 394 FGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDL 426 >3K9V-A nrPDB Length = 482 Score = 306 bits (783), Expect = 2e-83, Method: Composition-based stats. Identities = 96/440 (21%), Positives = 184/440 (41%), Gaps = 25/440 (5%) Query: 31 PGPTPLPVIGNILQI----GIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEA 86 PGPT P++G++L+I G+K +L K YG +F + G V L ++ EA Sbjct: 27 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSP-SLLEA 85 Query: 87 LIDLGEEFSGR----GIFPLAERANRGFGIVFSNGKKWKEIRR-FSLMTLRNFGMGKRSI 141 L R + N +G++ G++W+ +R F ++ + K + Sbjct: 86 LYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLMKPVEIMK--L 143 Query: 142 EDRVQEEARCLVE---ELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLM 198 + ++ E +E EL + D L IC +++ KRF ++ Sbjct: 144 DKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEA 203 Query: 199 EKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMN 258 IK + S + ++ ++ + K+ + I + VK ++ Sbjct: 204 LTFITAIKTMMSTFGKMM---VTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQR 260 Query: 259 NPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPE 318 Q FL + ++ H + + L +L A ETT+ +L + L L ++P+ Sbjct: 261 YSQQPGADFLCDIYQQDH-----LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQ 315 Query: 319 VTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRN 378 ++ +E++ V+ N++P +D +MPY A + E R +P + + Sbjct: 316 AQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTT-RTLDKPTVLGE 374 Query: 379 YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGE 438 Y +PKGT + ++ + F + F P +L + +PF GKR+C+G Sbjct: 375 YALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKI-NPFAHLPFGIGKRMCIGR 433 Query: 439 ALAGMELFLFLTSILQNFNL 458 LA ++L L L I+Q +++ Sbjct: 434 RLAELQLHLALCWIIQKYDI 453 >2X2N-A nrPDB Length = 475 Score = 283 bits (723), Expect = 2e-76, Method: Composition-based stats. Identities = 86/461 (18%), Positives = 173/461 (37%), Gaps = 39/461 (8%) Query: 30 PPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID 89 P P +P++G+I+Q G + ++ +FT+ K + ++ + Sbjct: 19 PVYPVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEHSRFFLP 78 Query: 90 LGEEFSGRGIFPLAERANRGFGIVFSN-GKKWKEIRRF--SLMTLRNFGMGKRSIEDRVQ 146 E S R ++ G G+ ++ + +E F +T+ F ++ +Q Sbjct: 79 RNEVLSPREVYSFMVPVF-GEGVAYAAPYPRMREQLNFLAEELTIAKF----QNFVPAIQ 133 Query: 147 EEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHK--RFDYKDQQFLNLMEKLNEN 204 E R + + N C +F + R ++F L+ K+ + Sbjct: 134 HEVRKFMAANWDKDEGEINLLEDCSTMIINTACQCLFGEDLRKRLDARRFAQLLAKMESS 193 Query: 205 IKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKV---KEHQESMDMNNPQ 261 + + F PI+ P + IL ++ ++ ++ Sbjct: 194 LIPAAV--------FLPILLKLPLPQSARCHEARTELQKILSEIIIARKAAAVNKDSSTS 245 Query: 262 DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHP---E 318 D + L + + + ++ + V AG T+S T +++L L+ HP + Sbjct: 246 DLLSGLLSAVYR----DGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLM-HPANVK 300 Query: 319 VTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRN 378 +++EIE + + D MP+ + E R L L V D+K + Sbjct: 301 HLEALRKEIEEFPAQLNYNNVMD--EMPFAERCARESIRRDPPL-LMLMRKVMADVKVGS 357 Query: 379 YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGE 438 Y++PKG I S HD + FP P +DP + K F+ F AG C+G+ Sbjct: 358 YVVPKGDIIACSPLLSHHDEEAFPEPRRWDPER------DEKVEGAFIGFGAGVHKCIGQ 411 Query: 439 ALAGMELFLFLTSILQNFNLKSLVDP-KNLDTTPVVNGFAS 478 +++ L + ++++ + L D + D +V G + Sbjct: 412 KFGLLQVKTILATAFRSYDFQLLRDEVPDPDYHTMVVGPTA 452 >3MDV-A nrPDB Length = 456 Score = 271 bits (692), Expect = 5e-73, Method: Composition-based stats. Identities = 90/430 (20%), Positives = 177/430 (41%), Gaps = 30/430 (6%) Query: 44 QIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLG---EEFSGRGIF 100 ++G + + + +K YGPV + K V++ E+VK+ L+ + R + Sbjct: 6 EVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQ 65 Query: 101 PLAERANRGFG-IVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVE--ELR 157 + G G + N ++W + RR + + S+ + E+A LVE E + Sbjct: 66 TVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLV--SLMETFNEKAEQLVEILEAK 123 Query: 158 KTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICN 217 +P +L +++ F + L + L++ +K++ I Sbjct: 124 ADGQTPVSMQDMLTYTAMDILAKAAFG----METSMLLGAQKPLSQAVKLMLEG---ITA 176 Query: 218 NFSPIIDYFPGTHNKLLK---NVAFMKSYILEKVKEHQESMDMNN--PQDFIDCFLMKME 272 + + + + PG +L + ++ F++ + V+ +E++ P D + L E Sbjct: 177 SRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEE 236 Query: 273 KEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIG 332 + + E L + V F AG ET++ L + ++ L + PE+ A++Q E++ VIG Sbjct: 237 GAQDD-------EGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG 289 Query: 333 RNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLT 392 R +D + Y V+ E R + + +P T +L S Sbjct: 290 SKRYLDFEDLGRLQYLSQVLKESLRLYPPA-WGTFRLLEEETLIDGVRVPGNTPLLFSTY 348 Query: 393 SVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSI 452 + + F +P F+P F G K + PFS G R C+G+ A ME+ + + + Sbjct: 349 VMGRMDTYFEDPLTFNPDRFGP--GAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKL 406 Query: 453 LQNFNLKSLV 462 LQ + + Sbjct: 407 LQRLEFRLVP 416 >5FSA-A nrPDB Length = 490 Score = 256 bits (654), Expect = 2e-68, Method: Composition-based stats. Identities = 84/477 (17%), Positives = 167/477 (35%), Gaps = 63/477 (13%) Query: 19 LWRQSSGRGKLPPGPTPL-PVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVL 77 + +++ PP P G+ G + + + + YG VF+ K + V Sbjct: 1 MAKKT------PPLVFYWIPWFGSAASYGQQ-PYEFFESCRQKYGDVFSFMLLGKIMTVY 53 Query: 78 HGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVF-SNGKKWKEIRRFSLMTLRNFGM 136 G + + + S + G G+++ + E ++F+ L Sbjct: 54 LGPKGHEFVFNAKLSDVSAEEAYKHLTTPVFGTGVIYDCPNSRLMEQKKFAKFALTTDS- 112 Query: 137 GKRSIEDRVQEEARCLVE----ELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYK-D 191 KR + +E V +L++ + +F D Sbjct: 113 FKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFD 172 Query: 192 QQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHN----KLLKNVAFMKSYILEK 247 + F L + + F+PI FP + + + +++ Sbjct: 173 RSFAQL--------------YSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKE 218 Query: 248 VKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLR 307 +K +E D++ +D ID L+ + + T + + N + + G T+++T Sbjct: 219 IKLRRERGDIDPNRDLIDSLLIH---STYKDGVKMTDQEIANLLIGILMGGQHTSASTSA 275 Query: 308 YALLLLLKHPEVTAKVQEEIERVI----GRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP 363 + LL L + P + + +E+ ++ G +D +P + + E R L Sbjct: 276 WFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPL- 334 Query: 364 TSLPHAVTCDIKFR--NYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKK 421 S+ VT ++ NY++PKG +L+S + F NPE FDP + Sbjct: 335 HSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANS 394 Query: 422 --------------------SKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458 S ++PF G+ C+GE A ++L LT+ + N Sbjct: 395 VSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRW 451 >4WMZ-A nrPDB Length = 539 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 92/489 (18%), Positives = 174/489 (35%), Gaps = 52/489 (10%) Query: 24 SGRGKLPPGPTPL-PVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEA 82 S R PP P +G+ + G+K + K YG +F+ + + V G + Sbjct: 50 SLRKDRPPLVFYWIPWVGSAVVYGMK-PYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKG 108 Query: 83 VKEALIDLGEEFSGRGIFPLAERANRGFGIVF-SNGKKWKEIRRFSL--MTLRNFGMGKR 139 + + S + G G+++ + E ++F +T F Sbjct: 109 HEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVP 168 Query: 140 SIEDRVQEEARCLVE-ELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLM 198 I + V + R L + D + K + Sbjct: 169 LIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGK----------EMR 218 Query: 199 EKLNENIKILSSPWIQICNNFSPIIDYFPGTH----NKLLKNVAFMKSYILEKVKEHQES 254 KL+ + L + + F+PI FP K + + +KE +++ Sbjct: 219 AKLDTDFAYL---YSDLDKGFTPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKN 275 Query: 255 MDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLL 314 D+ + +D ID M+ + + T + + N + + G T++ T + LL L Sbjct: 276 NDIQD-RDLIDSL---MKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLA 331 Query: 315 KHPEVTAKVQEEIERVI-GRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCD 373 + P+V ++ EE RV+ G + MP + + E R L SL V D Sbjct: 332 ERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPL-HSLFRKVMKD 390 Query: 374 IKFRN--YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNF------------ 419 + N Y+IP G +L+S ++ FPN F+ H + ++ + Sbjct: 391 MHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFG 450 Query: 420 ----KKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL-----KSLVDPKNLDTT 470 S ++PF G+ C+GE A +L + ++ ++ K++ P Sbjct: 451 AISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTSMV 510 Query: 471 PVVNGFASV 479 + G A + Sbjct: 511 TLPTGPAKI 519 >5JLC-A nrPDB Length = 515 Score = 254 bits (649), Expect = 5e-68, Method: Composition-based stats. Identities = 85/480 (17%), Positives = 176/480 (36%), Gaps = 48/480 (10%) Query: 24 SGRGKLPPGPTPL-PVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEA 82 S R PP P +G+ + G K + + K YG +F+ + + V G + Sbjct: 32 SLRKDRPPLVFYWIPWVGSAIPYGTK-PYEFFEDCQKKYGDIFSFMLLGRIMTVYLGPKG 90 Query: 83 VKEALIDLGEEFSGRGIFPLAERANRGFGIVF-SNGKKWKEIRRFSL--MTLRNFGMGKR 139 + + S + G G+++ + E ++F +T F Sbjct: 91 HEFIFNAKLADVSAEAAYSHLTTPVFGKGVIYDCPNHRLMEQKKFVKGALTKEAFVRYVP 150 Query: 140 SIEDRVQEEARCLVE-ELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLM 198 I + + + R ++ + + D + K + Sbjct: 151 LIAEEIYKYFRNSKNFKINENNSGIVDVMVSQPEMTIFTASRSLLGK----------EMR 200 Query: 199 EKLNENIKILSSPWIQICNNFSPIIDYFPGTH----NKLLKNVAFMKSYILEKVKEHQES 254 +KL+ + L + + F+PI FP K + + +KE +E Sbjct: 201 DKLDTDFAYL---YSDLDKGFTPINFVFPNLPLEHYRKRDHAQQAISGTYMSLIKERREK 257 Query: 255 MDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLL 314 D+ N +D ID M+ + ++ T + + N + + G T++ T + LL L Sbjct: 258 NDIQN-RDLIDEL---MKNSTYKDGTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLA 313 Query: 315 KHPEVTAKVQEEIERVIGRN-RSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCD 373 + P+V ++ +E RV+ + + D +MP + ++ E R L SL V D Sbjct: 314 ERPDVQEELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPL-HSLFRKVMRD 372 Query: 374 IKFRN--YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKK---------- 421 + N Y++P+ +L+S + FP P F+ H + + + Sbjct: 373 VAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDYGF 432 Query: 422 -------SKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVN 474 S ++PF G+ C+GE A +L + ++ ++ + + + + + + Sbjct: 433 GAISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRYPTEGETVPPSDFTS 492 >6CR2-A nrPDB Length = 477 Score = 251 bits (640), Expect = 6e-67, Method: Composition-based stats. Identities = 86/477 (18%), Positives = 171/477 (35%), Gaps = 50/477 (10%) Query: 19 LWRQSSGRGKLPPGPTPL-PVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVL 77 + +++ PP P IG+ + GI D K + YG +FT K V Sbjct: 1 MAKKT------PPVVFHWFPFIGSTISYGI-DPYKFFFDCRAKYGDIFTFILLGKKTTVY 53 Query: 78 HGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVF-SNGKKWKEIRRFSLMTLRNFGM 136 G + L + ++ G +V+ K E ++F L + + Sbjct: 54 LGTKGNDFILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQKKFVKYGLTSDAL 113 Query: 137 GKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLN 196 RS + +E V+ + C I I Y + L Sbjct: 114 --RSYVPLITDEVESFVKNSPAFQGHKG------VFDVCKTIAEITI-----YTASRSLQ 160 Query: 197 LMEKLNENIKILSSPWIQICNNFSPI---IDYFPGTH-NKLLKNVAFMKSYILEKVKEHQ 252 E ++ + + + F+PI + + P H K + +E +K + Sbjct: 161 GKEVRSKFDSTFAELYHNLDMGFAPINFMLPWAPLPHNRKRDAAQRKLTETYMEIIKARR 220 Query: 253 ESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLL 312 ++ + +D + + + + + E + + + L AG ++S+T + +L Sbjct: 221 QAGSKKDSEDMVWNLMSCV----YKNGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLR 276 Query: 313 LLKHPEVTAKVQEEIERVIGRNRSPCMQD-RSHMPYTDAVVHEVQRYIDLLPTSLPHAVT 371 L P++ ++ +E RV+G + P D + V+ E R + S+ AV Sbjct: 277 LATRPDIMEELYQEQIRVLGSDLPPLTYDNLQKLDLHAKVIKETLRLHAPI-HSIIRAVK 335 Query: 372 CDIKFRN--YLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKK-------- 421 + Y+IP +L S + FPNP ++PH + + + Sbjct: 336 NPMAVDGTSYVIPTSHNVLSSPGVTARSEEHFPNPLEWNPHRWDENIAASAEDDEKVDYG 395 Query: 422 --------SKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTT 470 + ++PF AG+ C+GE A ++L +++ F ++L + T Sbjct: 396 YGLVSKGTNSPYLPFGAGRHRCIGEQFAYLQLGTITAVLVRLFRFRNLPGVDGIPDT 452 >2W0A-A nrPDB Length = 455 Score = 232 bits (591), Expect = 3e-61, Method: Composition-based stats. Identities = 75/437 (17%), Positives = 160/437 (36%), Gaps = 32/437 (7%) Query: 40 GNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGI 99 G++ + D + + G V T K +V+L G A + ++ Sbjct: 17 GHLEEF-RTDPIGLMQRVRDELGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKA 75 Query: 100 FPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKT 159 +P + ++ ++ KE+ + + +IED+V+ E Sbjct: 76 YPFMTPIFGEAVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQVRRMIADWGEAGE-- 133 Query: 160 KASPCDPTFILGCAPCNVICSIIFHKRF-DYKDQQFLNLMEKLNENIKILSSPWIQICNN 218 D + + K+F D D +F L + ++ Sbjct: 134 ----IDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKL--------------YHELERG 175 Query: 219 FSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNP-----QDFIDCFLMKMEK 273 P+ P + + ++ ++ V + N P +D +D L+ ++ Sbjct: 176 TDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLD-VLIAVKA 234 Query: 274 EKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGR 333 E F+ + + + + AG T+S T + L+ L++H + A V +E++ + G Sbjct: 235 ETGTP--RFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGD 292 Query: 334 NRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTS 393 RS +P + V+ E R L L + + + + I +G + S Sbjct: 293 GRSVSFHALRQIPQLENVLKETLRLHPPL-IILMRVAKGEFEVQGHRIHEGDLVAASPAI 351 Query: 394 VLHDNKEFPNPEMFDPHHFLDEGGNFKKSKY-FMPFSAGKRICVGEALAGMELFLFLTSI 452 ++FP+P F P + +++ ++PF AG+ CVG A A M++ + + Sbjct: 352 SNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVL 411 Query: 453 LQNFNLKSLVDPKNLDT 469 L+ + + P++ Sbjct: 412 LREYEFEMAQPPESYRN 428 >6C94-A nrPDB Length = 497 Score = 231 bits (589), Expect = 5e-61, Method: Composition-based stats. Identities = 77/447 (17%), Positives = 165/447 (36%), Gaps = 18/447 (4%) Query: 31 PGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLK-PIVVLHGYEAVKEALID 89 PGP + G+ L+I + ++ + L+ G + ++ + K A+ Sbjct: 25 PGPPTHWLFGHALEIQKTGSLDKVVTWTQQFPYAHPLWVGQFIGFLNIYEPDYAK-AVYS 83 Query: 90 LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEA 149 G+ + G G++ +G KW + R+ + + + Sbjct: 84 RGDPKA--PDVYDFFLQWIGKGLLVLDGPKWFQHRKLLTPGFHYDVL--KPYVAIFADST 139 Query: 150 RCLVE--ELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKI 207 R ++E E + + D +G + + F K D + + + Sbjct: 140 RIMLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGKG-DSGLNHRDSSYYVAVSELTL 198 Query: 208 LSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFID-- 265 L I + I + + L+ + +++ + ++ ++ I Sbjct: 199 LMQQRIDSFQYHNDFIYWLTPHGRRFLRACRAAHDHTDRVIRQRKAALQDEKEREKIQNR 258 Query: 266 ---CFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAK 322 FL + + + + L G +TT++ + + L + +PE + Sbjct: 259 RHLDFLDILLDVRGESGVQLSDTDLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQR 318 Query: 323 VQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIK-FRNYLI 381 +EE+ ++G S +D + M Y + E R +P + ++ + + Sbjct: 319 CREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQ-VYRQLSKPVSFVDGRSL 377 Query: 382 PKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALA 441 P G+ I + + ++ ++ +P+PE+FDP F E + + F+PFSAG R C+G+ A Sbjct: 378 PAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRHPYAFIPFSAGPRNCIGQQFA 437 Query: 442 GMELFLFLTSILQNFNLKSLVDPKNLD 468 E+ + L F VDP L Sbjct: 438 MNEMKVVTALCLLRFEFS--VDPLRLP 462 >2VE3-A nrPDB Length = 444 Score = 227 bits (579), Expect = 8e-60, Method: Composition-based stats. Identities = 92/446 (20%), Positives = 175/446 (39%), Gaps = 37/446 (8%) Query: 29 LPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALI 88 +PPG LP +G L + +GP+F K ++ + G A + Sbjct: 13 IPPGDFGLPWLGETLNFLNDG--DFGKKRQQQFGPIFKTRLFGKNVIFISGALANRFLFT 70 Query: 89 DLGEEFSGRGIFPLAERANRG-FGIVFSNGKKWKEIRRFSLMTL--RNFGMGKRSIEDRV 145 E F + +PL+ R G + G+ + R+ R ++ V Sbjct: 71 KEQETF--QATWPLSTRILLGPNALATQMGEIHRSRRKILYQAFLPRTLDSYLPKMDGIV 128 Query: 146 QEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENI 205 Q + VI +R + L + EK+++N Sbjct: 129 QGYLEQWGKANE-------------------VIWYPQL-RRMTFDVAATLFMGEKVSQNP 168 Query: 206 KILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFID 265 ++ I FS I N L ++ +L ++++ ++ P + + Sbjct: 169 QLFPWFETYIQGLFSLPIPL----PNTLFGKSQRARALLLAELEKIIKARQQQPPSE--E 222 Query: 266 CFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQE 325 L + + + ++ L++ + L AG ET ++ L LLL +H ++ +V++ Sbjct: 223 DALGILLAARDDNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQ 282 Query: 326 EIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGT 385 E + + ++ + MPY D V+ EV R I + + D +F+ + PKG Sbjct: 283 E-QNKLQLSQELTAETLKKMPYLDQVLQEVLRLIPPVGGGF-RELIQDCQFQGFHFPKGW 340 Query: 386 TILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK-KSKYFMPFSAGKRICVGEALAGME 444 + ++ D +P+PE FDP F +G +PF G R C+G+ A +E Sbjct: 341 LVSYQISQTHADPDLYPDPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECLGKEFARLE 400 Query: 445 LFLFLTSILQNFNLKSLVDPKNLDTT 470 + LF T ++Q F+ +L+ +NL+ Sbjct: 401 MKLFATRLIQQFDW-TLLPGQNLELV 425 >2VZM-A nrPDB Length = 436 Score = 225 bits (574), Expect = 3e-59, Method: Composition-based stats. Identities = 84/455 (18%), Positives = 151/455 (33%), Gaps = 72/455 (15%) Query: 34 TPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFG-LKPIVVLHGYEAVKEALID--L 90 P+ +G + Q D + L GP + + ++ GY+ + L D Sbjct: 32 PPVLDLGALGQDFAADPYPTYARLR-AEGPAHRVRTPEGNEVWLVVGYDRARAVLADPRF 90 Query: 91 GEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSI-EDRVQEEA 149 +++ A ++ S+ + +R+ R F M + + RVQE Sbjct: 91 SKDWRNSTTPLTEAEAALNHNMLESDPPRHTRLRKLV---AREFTMRRVELLRPRVQEIV 147 Query: 150 RCLVEELRKTKASPCDPTFILGC-APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKIL 208 LV+ + D L P VI + L + E ++ Sbjct: 148 DGLVDAMLAAPDGRADLMESLAWPLPITVIS-------------ELLGVPEPDRAAFRVW 194 Query: 209 SSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFL 268 + + FP + +A M Y+ + + + L Sbjct: 195 TDAF------------VFPDDPAQAQTAMAEMSGYLSRLIDSKR--------GQDGEDLL 234 Query: 269 MKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIE 328 + + S T E L A L AG ETT + + LL HP+ A ++ + Sbjct: 235 SALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRAD-- 292 Query: 329 RVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTIL 388 M D V E+ RY + ++ + +IP G T+L Sbjct: 293 ----------------MTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVL 336 Query: 389 ISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLF 448 + L + FP+P FD + + F G C+G LA +E + Sbjct: 337 VVLADAHRTPERFPDPHRFDIRR---------DTAGHLAFGHGIHFCIGAPLARLEARIA 387 Query: 449 LTSILQNFNLKSL-VDPKNLDT--TPVVNGFASVP 480 + ++L+ +L V P L P++ G ++P Sbjct: 388 VRALLERCPDLALDVSPGELVWYPNPMIRGLKALP 422 >5L1U-A nrPDB Length = 401 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 93/460 (20%), Positives = 153/460 (33%), Gaps = 96/460 (20%) Query: 46 GIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAER 105 I I+ + L + GP+ + + ++ Y+ V+ L D S P A+ Sbjct: 16 DIMGIAPQMLAL-QKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQPSAKS 74 Query: 106 ANRGFGIVFSNGKKWKE------------IRRFSLMTLRNFGMGKRSIEDRVQEEARCLV 153 A R F + + G + I RFS LR + K IE V E L Sbjct: 75 AARAFMVALAAGDDHETEPARHAQMRSLLIPRFSTRRLR---LMKTRIEHHVDELLDQL- 130 Query: 154 EELRKTKASPCDPTFILG-CAPCNVICSII---FHKRFDYKDQQFLNLMEKLNENIKILS 209 A P D +L P V+C ++ R + + NE+ Sbjct: 131 ----AASAPPVDLHRVLSFRLPTMVVCDLLGVPLADRERFGQWARGTFDQSDNEHSAN-- 184 Query: 210 SPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLM 269 + Y+LE V + + D L Sbjct: 185 --------------------------TFQQVVDYMLELVARKRV--------EPGDDILS 210 Query: 270 KMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIER 329 ++ EK S+ I L AV LF G ETT + LLLL++P A++ E+ Sbjct: 211 ELIAEKDGALSDADIAHL-GNAVLLF--GYETTIVRIDLGTLLLLRNPVQRAQLAEDPG- 266 Query: 330 VIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTS---LPHAVTCDIKFRNYLIPKGTT 386 A V E+ R S +P DI +I G Sbjct: 267 -----------------LAPAAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDA 309 Query: 387 ILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELF 446 +++++ + +D++ FP+ +FD + + + F G R C+G LA +EL Sbjct: 310 VMLAIGAANYDDRAFPDGGLFDLTRV--------RPRSHLAFGHGARHCIGRTLARIELT 361 Query: 447 LFLTSILQNFNLKSLVDPK---NLDTTPVVNGFASVPPFY 483 + + L P+ + GF +P + Sbjct: 362 AVFERLFRRLPDLRLAVPEESLRWQEHRITGGFDEIPVTF 401 >3EL3-A nrPDB Length = 467 Score = 219 bits (559), Expect = 2e-57, Method: Composition-based stats. Identities = 82/438 (18%), Positives = 161/438 (36%), Gaps = 22/438 (5%) Query: 30 PPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID 89 P +P++G+ ++ +D ++ L +G V + G K + + E + AL Sbjct: 25 PVAGGGVPLLGHGWRLA-RDPLAFMSQLRD-HGDVVRIKLGPKTVYAVTNPE-LTGALAL 81 Query: 90 LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEA 149 + ++ E G+ +NG + RR R + + ++EEA Sbjct: 82 NPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAI--PAYGPIMEEEA 139 Query: 150 RCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILS 209 L E R D T V + ++ + + L + + + Sbjct: 140 HALTE--RWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCV------ALATVF 191 Query: 210 SPWIQICNNFSPIIDYFPGTHNKLLK-NVAFMKSYILEKVKEHQESMDMNNPQDFIDCFL 268 + + P N+ +A + + E + E + S D L Sbjct: 192 RGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKP------DDLL 245 Query: 269 MKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIE 328 + + K + + + + V + G+ET ++T+ + L L HPE ++++E+E Sbjct: 246 TALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVE 305 Query: 329 RVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTIL 388 V G R +D + +T V+ E R + L + + Y IP G I+ Sbjct: 306 AVTG-GRPVAFEDVRKLRHTGNVIVEAMRLRPAV-WVLTRRAVAESELGGYRIPAGADII 363 Query: 389 ISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLF 448 S ++ D K + + FDP +L E PFSAGKR C + + +L L Sbjct: 364 YSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLI 423 Query: 449 LTSILQNFNLKSLVDPKN 466 ++ + + + + Sbjct: 424 TAALATKYRFEQVAGSND 441 >3EJB-B nrPDB Length = 404 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 90/446 (20%), Positives = 158/446 (35%), Gaps = 71/446 (15%) Query: 47 IKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERA 106 +K+ L V+ P++ F P + GYE L F R P + Sbjct: 12 LKNPYSFYDTLRAVH-PIYKGSFLKYPGWYVTGYEETAAIL--KDARFKVRTPLPESSTK 68 Query: 107 NRG------FGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK 160 + ++F N + +R + S + + E L+++++ K Sbjct: 69 YQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTPRT--TESYQPYIIETVHHLLDQVQGKK 126 Query: 161 ASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFS 220 F A VI +II +D++ L K ++ IQ + F+ Sbjct: 127 KMEVISDFAFPLASF-VIANIIG---VPEEDREQL----------KEWAASLIQTID-FT 171 Query: 221 PIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPS 280 + ++ +A+ K I +K K H + QD I L EK+K Sbjct: 172 RSRKALTEGNIMAVQAMAYFKELI-QKRKRHPQ-------QDMISMLLKGREKDK----- 218 Query: 281 EFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQ 340 T E +T + L AG ETT + ++L LL+HPE K++E + + Sbjct: 219 -LTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLI---------- 267 Query: 341 DRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKE 400 V E RY + + DI I +G + + L + D Sbjct: 268 --------GTAVEECLRYESPTQMTA-RVASEDIDICGVTIRQGEQVYLLLGAANRDPSI 318 Query: 401 FPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKS 460 F NP++FD + F G +C+G +LA +E + + ++LQ + Sbjct: 319 FTNPDVFDITR---------SPNPHLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLN 369 Query: 461 LVDPKNLDTTPV--VNGFASVPPFYQ 484 L D P+ +P ++ Sbjct: 370 LAD-FEWRYRPLFGFRALEELPVTFE 394 >3N9Z-A nrPDB Length = 487 Score = 216 bits (550), Expect = 2e-56, Method: Composition-based stats. Identities = 79/444 (17%), Positives = 165/444 (37%), Gaps = 26/444 (5%) Query: 31 PGPTPLPVIGNIL-QIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID 89 PG + + + G + + YGP++ G V + E V Sbjct: 14 PGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKS 73 Query: 90 LG---EEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQ 146 G E F + R G++ WK+ R +L ++ + Sbjct: 74 EGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDR-VALNQEVMAPEATKNFLPLLD 132 Query: 147 EEARCLVEELRK------TKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEK 200 +R V L + + D + L I ++IF +R ++ ++ Sbjct: 133 AVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQR 192 Query: 201 LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQES-----M 255 + I + + + N D F K K+ I K + ++ Sbjct: 193 FIDAIYQMFHTSVPMLNLPP---DLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELR 249 Query: 256 DMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLK 315 + L ++ + S+ + E ++ ++ G +TTS TL++ L + + Sbjct: 250 QKGSVHHDYRGILYRLLGD-----SKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMAR 304 Query: 316 HPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIK 375 + +V ++ E+ + + +P A + E R + +L + D+ Sbjct: 305 NLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRL-HPISVTLQRYLVNDLV 363 Query: 376 FRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRIC 435 R+Y+IP T + +++ ++ + F +PE FDP +L + N + F G R C Sbjct: 364 LRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNI-TYFRNLGFGWGVRQC 422 Query: 436 VGEALAGMELFLFLTSILQNFNLK 459 +G +A +E+ +FL ++L+NF ++ Sbjct: 423 LGRRIAELEMTIFLINMLENFRVE 446 >2Y5N-A nrPDB Length = 417 Score = 215 bits (548), Expect = 3e-56, Method: Composition-based stats. Identities = 84/424 (19%), Positives = 148/424 (34%), Gaps = 83/424 (19%) Query: 71 LKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANR----GFGIVFSNGKKWKEIRRF 126 + ++ YE V+ L D F E R G++ + + +RR Sbjct: 60 GEEAWLVTRYEDVRAVLGD--GRFVRGPSMTRDEPRTRPEMVKGGLLSMDPPEHSRLRRL 117 Query: 127 SLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCA-PCNVICSIIF-- 183 + S+ R +E A LV+++ T P D + P VIC ++ Sbjct: 118 VVKAFT--ARRAESLRPRAREIAHELVDQMAAT-GQPADLVAMFARQLPVRVICELLGVP 174 Query: 184 ---HKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 240 H RF FL+ E E ++ + + A+M Sbjct: 175 SADHDRFTRWSGAFLSTAEVTAEEMQEAAE------------------------QAYAYM 210 Query: 241 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 300 I + KE P D + L+ + +Q + + L + A+ L AG E Sbjct: 211 GDLIDRRRKE---------PTDDLVSALV----QARDQQDSLSEQELLDLAIGLLVAGYE 257 Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360 +T+T + + LL+ PE+ ++ + E + + V E+ R++ Sbjct: 258 STTTQIADFVYLLMTRPELRRQLLDRPELI------------------PSAVEELTRWVP 299 Query: 361 L-LPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNF 419 L + T+ P D+ R I G +L S + D +FP+ + D Sbjct: 300 LGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDR-------- 351 Query: 420 KKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPK---NLDTTPVVNGF 476 + F G C+G LA +EL + L +LQ L P+ ++ G Sbjct: 352 -TPNQHLGFGHGVHHCLGAPLARVELQVALEVLLQRLPGIRLGIPETQLRWSEGMLLRGP 410 Query: 477 ASVP 480 +P Sbjct: 411 LELP 414 >4ZGX-A nrPDB Length = 489 Score = 211 bits (538), Expect = 5e-55, Method: Composition-based stats. Identities = 89/420 (21%), Positives = 164/420 (39%), Gaps = 51/420 (12%) Query: 46 GIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFP--LA 103 G + + + + GP+F G +V + E V E L + R I +A Sbjct: 37 GYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDV-EKLQQVDSLHPCRMILEPWVA 95 Query: 104 ERANRGF--GIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIE---DRVQEEARCLVEELRK 158 R +RG G+ NG +W RF+ + L + ++++ V AR + L+K Sbjct: 96 YRQHRGHKCGVFLLNGPEW----RFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKK 151 Query: 159 TKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNN 218 + L P IFH + + + E + ++ N Sbjct: 152 KVLQNARGSLTLDVQPS------IFHYTIEASN------LALFGERLGLVGHSPSSASLN 199 Query: 219 FSPIIDYFPGTHNKLLKNVAFMKSYILEKV-KEHQESMD------------------MNN 259 F ++ + +L+ + +I KV KEH E+ D N Sbjct: 200 FLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNR 259 Query: 260 PQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEV 319 PQ + + K E ++E+++ +++L +TT+ L L L ++P+V Sbjct: 260 PQHYTGIVAELLLKA------ELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDV 313 Query: 320 TAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNY 379 +++E + + +P A + E R + L V+ D+ +NY Sbjct: 314 QQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVG-LFLERVVSSDLVLQNY 372 Query: 380 LIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEA 439 IP GT + + L S+ + FP PE ++P +LD G+ + + + +PF G R C+G Sbjct: 373 HIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGR-NFHHVPFGFGMRQCLGRR 431 >3MZS-A nrPDB Length = 486 Score = 210 bits (535), Expect = 1e-54, Method: Composition-based stats. Identities = 81/445 (18%), Positives = 163/445 (36%), Gaps = 27/445 (6%) Query: 31 PGPTPLPVIGNIL-QIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID 89 PG + + + G + I + YGP++ G V + E V Sbjct: 16 PGDNGWLNLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKF 75 Query: 90 LG---EEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQ 146 G E + + G++F WK+ R L T ++ + Sbjct: 76 EGSYPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDR-VVLNTEVMAPEAIKNFIPLLN 134 Query: 147 EEARCLVEELRKTKAS------PCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEK 200 ++ V L K D L I +++F +R ++ +K Sbjct: 135 PVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVNPEAQK 194 Query: 201 LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEH-----QESM 255 + + + + + N + F K ++ I K +++ Q+ Sbjct: 195 FIDAVYKMFHTSVPLLNVPPELYRLF---RTKTWRDHVAAWDTIFNKAEKYTEIFYQDLR 251 Query: 256 DMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLK 315 +++ ++ EK +E ++ ++ G TTS TL++ L + + Sbjct: 252 RKTEFRNYPGILYCLLKSEK------MLLEDVKANITEMLAGGVNTTSMTLQWHLYEMAR 305 Query: 316 HPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIK 375 V ++EE+ + + +P A + E R + +L D+ Sbjct: 306 SLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRL-HPISVTLQRYPESDLV 364 Query: 376 FRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRIC 435 ++YLIP T + +++ ++ D F +P+ FDP +L + + + + F G R C Sbjct: 365 LQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFR-NLGFGWGVRQC 423 Query: 436 VGEALAGMELFLFLTSILQNFNLKS 460 VG +A +E+ LFL IL+NF ++ Sbjct: 424 VGRRIAELEMTLFLIHILENFKVEM 448 >6M7X-A nrPDB Length = 484 Score = 209 bits (531), Expect = 3e-54, Method: Composition-based stats. Identities = 92/456 (20%), Positives = 171/456 (37%), Gaps = 60/456 (13%) Query: 19 LWRQSSG--RGKLP-------PGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYF 69 + +++S R LP PG L ++ + G +D+ + + GP+F Sbjct: 1 MAKKTSSVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDL 60 Query: 70 GLKPIVVLHGYEAVKEALIDLGEEFSGRGIFP--LAERANRGF--GIVFSNGKKWKEIRR 125 G +V + E V E L + R +A R +RG G+ NG +W R Sbjct: 61 GGAGMVCVMLPEDV-EKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEW----R 115 Query: 126 FSLMTLRNFGMGKRSIE---DRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSII 182 F+ + L + +++ V AR + L+K + L P I Sbjct: 116 FNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPS------I 169 Query: 183 FHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKS 242 FH + + + E + ++ NF ++ + +L+ + Sbjct: 170 FHYTIEASN------LALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSR 223 Query: 243 YILEKV-KEHQESMD------------------MNNPQDFIDCFLMKMEKEKHNQPSEFT 283 + KV KEH E+ D + PQ + + E + Sbjct: 224 WTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNA------ELS 277 Query: 284 IESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRS 343 ++++ +++L +TT L L L ++P V +++E + + Sbjct: 278 PDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATT 337 Query: 344 HMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPN 403 +P A + E R + L + D+ +NY IP GT + + L S+ + FP Sbjct: 338 ELPLLRAALKETLRLYPVG-LFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPR 396 Query: 404 PEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEA 439 PE ++P +LD G+ + + Y +PF G R C+G Sbjct: 397 PERYNPQRWLDIRGSGR-NFYHVPFGFGMRQCLGRR 431 >5CJE-A nrPDB Length = 393 Score = 208 bits (530), Expect = 4e-54, Method: Composition-based stats. Identities = 85/455 (18%), Positives = 155/455 (34%), Gaps = 78/455 (17%) Query: 39 IGNILQIG------IKDISKSLTNLSKVYGPVFTLYFGLKPI---VVLHGYEAVKEALID 89 +GN++ +G +D L + GPV + ++ G+E + AL D Sbjct: 1 MGNVIDLGEYGARFTEDPYPVYAELRER-GPVHWVRTPPPEAFEGWLVVGHEEARAALAD 59 Query: 90 LGEEFSG-RGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK-RSIEDRVQE 147 G + + G ++ + + +R R F M + ++ R+QE Sbjct: 60 PRLSKDGTKKGLTSLDVELMGPYLLVVDPPEHTRLRSLV---ARAFTMRRVEALRPRIQE 116 Query: 148 EARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIK 206 L++E+ D P VIC ++ D + NE + Sbjct: 117 ITDGLLDEM--LPRGRADLVDSFAYPLPITVICELLGVPDIDR-----VTFRALSNEIVA 169 Query: 207 ILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDC 266 P + L + +Y+ E + + + + P D + Sbjct: 170 --------------------PTGGDAELAAYERLAAYLDELIDDKRST----APADDLLG 205 Query: 267 FLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEE 326 L++ E + + E L A L AG ETT + + LL HP+ A ++ + Sbjct: 206 DLIRTRAEDDD---RLSGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAALRAD 262 Query: 327 IERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTT 386 M D V EV R+ + T+ ++ I +G Sbjct: 263 ------------------MTLLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIAEGDP 304 Query: 387 ILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELF 446 ++I L + D P+P +FD H + + F G C+G LA +E Sbjct: 305 VMIGLDAAGRDPARHPDPHVFDIHR---------APQGHLAFGHGIHYCLGAPLARLEAR 355 Query: 447 LFLTSILQNFNLKSLV-DPKNLDTTPVVNGFASVP 480 + L S+L+ +L P ++ G +P Sbjct: 356 VALRSLLERCPDLALDGPPGARPPGMLIRGVRRLP 390 >1Z8P-A nrPDB Length = 404 Score = 208 bits (528), Expect = 7e-54, Method: Composition-based stats. Identities = 78/435 (17%), Positives = 151/435 (34%), Gaps = 80/435 (18%) Query: 63 PVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGF------------ 110 PV + F + ++ GY+ K AL DL + +P E + Sbjct: 28 PVTPVRFLGQDAWLVTGYDEAKAALSDLRLSSDPKKKYPGVEVEFPAYLGFPEDVRNYFA 87 Query: 111 -GIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFI 169 + S+ +R+ ++ RV++ L++E+ + D Sbjct: 88 TNMGTSDPPTHTRLRKLVSQEFT--VRRVEAMRPRVEQITAELLDEVGDS--GVVDIVDR 143 Query: 170 LGC-APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPG 228 P VIC + L + EK SS + + P Sbjct: 144 FAHPLPIKVIC-------------ELLGVDEKYRGEFGRWSSEILVMD----------PE 180 Query: 229 THNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLE 288 + + + ++IL+ V+ + + D L + + + + + + L Sbjct: 181 RAEQRGQAAREVVNFILDLVERRR--------TEPGDDLLSALIRVQDDDDGRLSADELT 232 Query: 289 NTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYT 348 + A+ L AG E++ + + LLL HP+ A V+ + Sbjct: 233 SIALVLLLAGFESSVSLIGIGTYLLLTHPDQLALVRRDPSA------------------L 274 Query: 349 DAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFD 408 V E+ RYI P + +++ IP+ +T+L++ + D K+FP+P FD Sbjct: 275 PNAVEEILRYIAP-PETTTRFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFPDPHRFD 333 Query: 409 PHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSL---VDPK 465 ++ + F G C+G LA +E + L ++ F SL D Sbjct: 334 VTR---------DTRGHLSFGQGIHFCMGRPLAKLEGEVALRALFGRFPALSLGIDADDV 384 Query: 466 NLDTTPVVNGFASVP 480 + ++ G +P Sbjct: 385 VWRRSLLLRGIDHLP 399 >5VWS-A nrPDB Length = 393 Score = 207 bits (527), Expect = 9e-54, Method: Composition-based stats. Identities = 79/395 (20%), Positives = 132/395 (33%), Gaps = 63/395 (15%) Query: 63 PVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKE 122 PV+ FG I + Y+ V++ L D S R + GI + + + Sbjct: 32 PVWRDQFG---IYHVFRYDDVRQILGDYQTFSSDRTRLMPTAQGFGKGGITMIDPPEHRH 88 Query: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSI 181 RR + ++E R+++ A L++EL D P VI + Sbjct: 89 QRRLITHAFTPQSIS--AMEPRIRQIADHLLDEL---PGPEFDLVEHFAYPLPVIVIAEL 143 Query: 182 IFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMK 241 + D+ W + P + + M Sbjct: 144 LG---VPPGDRHLFR--------------TWSDRLMSLQVENYADPELARTVAAAMTEMN 186 Query: 242 SYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTET 301 Y+ +EH S +P+D + L++ E E +E + NTA L AG T Sbjct: 187 DYL----REHCRSR-RTHPRDDLLTRLVQAEVE----GKRLDLEEVVNTASLLLLAGHLT 237 Query: 302 TSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDL 361 T+ + +L L HPE V+ + + A + E R Sbjct: 238 TTVLIGNTMLCLWDHPEAEKAVRADPSLI------------------PAALEESLRLRSP 279 Query: 362 LPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKK 421 T D+ IP ++ + S HD++ FP+PE FD H + Sbjct: 280 F-LQAGRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPERFDLHR---------Q 329 Query: 422 SKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456 + + F G C+G L +E + L +L F Sbjct: 330 TTGHIAFGHGVHFCLGAQLGRLEGRIALERLLGRF 364 >5EX6-C nrPDB Length = 434 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 76/419 (18%), Positives = 145/419 (34%), Gaps = 82/419 (19%) Query: 62 GPVFTLYFGL----KPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFS-- 115 G + + G + + G++ V++ L D FS R F + G G+ Sbjct: 62 GELTRVRLGSGADAEHTWLATGHDVVRQVLGDH-TRFSTRRRFDRNDEI-GGKGVFRPRE 119 Query: 116 --------NGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPT 167 + + +RR + + R + +++ ++E+ + SP D Sbjct: 120 LVGNLMDYDPPEHTRLRRLLAPGFTHRKI--RRMAPYIEQIVTERLDEMERE-GSPADLI 176 Query: 168 FIL-GCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYF 226 + P V+C ++ R D + ++Q+C+ +D Sbjct: 177 ELFADEVPGPVLCELLGVPRDDR--------------------AMFLQLCHRH---LDAS 213 Query: 227 PGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIES 286 + AF + + +E + D D + + E T E Sbjct: 214 LSGRRRAAAGEAFSRYLVTMVARERK---------DPGDGLIGMVVAEH---GDTVTDEE 261 Query: 287 LENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMP 346 L V + AG + S + +L LL++PE A ++ ++ P Sbjct: 262 LRGVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAALRGDV------------------P 303 Query: 347 YTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEM 406 + V E+ RY+ + P D + +I G T+L SL + D P+ + Sbjct: 304 AAERAVDELIRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDADR 363 Query: 407 FDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPK 465 D ++ + F G C+G ALA +EL + T++ + F L DP Sbjct: 364 LDVTR---------EAVPHVAFGHGVHHCLGAALARLELRIAYTALWRRFPDLRLADPD 413 >4OQS-A nrPDB Length = 433 Score = 205 bits (521), Expect = 4e-53, Method: Composition-based stats. Identities = 83/420 (19%), Positives = 142/420 (33%), Gaps = 85/420 (20%) Query: 75 VVLHGYEAVKEALIDLGEEFSGRG--IFPLAERANRGFGIVFSNGKKW------KEIRRF 126 ++ + A + +ID FS R P+ R G + W E R+ Sbjct: 48 WLVTSHAAARTVMID--PRFSNRPEHKHPVFSVIPRPGGATKAPAPGWFINMDAPEHTRY 105 Query: 127 SLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFH 184 M + F + + + +E R+ + ++ + K P D P VIC ++ Sbjct: 106 RRMLISQFTVRRIKELEPRIVQITEDHLDAMAK-AGPPVDLVQAFALPVPSLVICELLG- 163 Query: 185 KRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYI 244 Y D F + ++ T +++ + + YI Sbjct: 164 --VSYADHAFFQEQTTIMASVD---------------------KTQDEVTTALGKLTRYI 200 Query: 245 LEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTST 304 E V + S D + + ++ T E L N A+ L AG ETT+ Sbjct: 201 AELVATKRLS----PKDDLLGSLITD---------TDLTDEELTNIALLLLVAGHETTAN 247 Query: 305 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPT 364 L LL+HPE A + + V E+ RY+ ++ Sbjct: 248 MLGLGTFALLQHPEQIAALD-----------------------SPDAVEELLRYLSIVHL 284 Query: 365 SLP-HAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSK 423 P A D++ +I KG T+ I L +V D K F P++ ++ Sbjct: 285 GTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDRV--------DAR 336 Query: 424 YFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKN---LDTTPVVNGFASVP 480 F G C+G+ LA +E+ + T + F L P L G ++P Sbjct: 337 KHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEIKLREKSAAYGVWALP 396 >4OQR-A nrPDB Length = 457 Score = 203 bits (516), Expect = 2e-52, Method: Composition-based stats. Identities = 83/420 (19%), Positives = 141/420 (33%), Gaps = 85/420 (20%) Query: 75 VVLHGYEAVKEALIDLGEEFSGRG--IFPLAERANRGFGIVFSNGKKW------KEIRRF 126 ++ + A + +ID FS R P+ R G + W E R+ Sbjct: 87 WLVTSHAAARTVMID--PRFSNRPEHKHPVFSVIPRPGGATKAPAPGWFTNMDAPEHTRY 144 Query: 127 SLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFH 184 M + F + + + +E R+ ++ + K P D P VIC ++ Sbjct: 145 RRMLISQFTVRRIKELEPRIVRITEDHLDAMAK-AGPPVDLVQAFALPVPSLVICELLG- 202 Query: 185 KRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYI 244 Y D F + ++ T +++ + + YI Sbjct: 203 --VSYADHAFFQEQTTIMVSVD---------------------KTQDEVTTALGKLTRYI 239 Query: 245 LEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTST 304 E V + S D + + ++ T E L N A+ L AG ETT+ Sbjct: 240 AELVATKRLS----PKDDLLGSLITD---------TDLTDEELTNIALILLVAGHETTAN 286 Query: 305 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPT 364 L LL+HPE A + + V E+ RY+ ++ Sbjct: 287 MLGLGTFALLQHPEQIANLD-----------------------SPDAVEELLRYLSIVHL 323 Query: 365 SLP-HAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSK 423 P A D++ +I KG T+ I L +V D K F P++ ++ Sbjct: 324 GTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDRV--------DAR 375 Query: 424 YFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKN---LDTTPVVNGFASVP 480 F G C+G+ LA +E+ + T + F L P L G ++P Sbjct: 376 KHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFPSLRLAVPAEEIKLREKSAAYGVWALP 435 >5Y1I-A nrPDB Length = 403 Score = 203 bits (515), Expect = 2e-52, Method: Composition-based stats. Identities = 82/429 (19%), Positives = 153/429 (35%), Gaps = 79/429 (18%) Query: 66 TLYFGLKPIVVLHGYEAVKEALIDLGEEFSG-RGIFPLAERANRGFGIV---FS--NGKK 119 ++ G P V+ + + L D G R +P + + F+ + + Sbjct: 37 RIWDGSTP-WVVTRHADQRALLSDPRVSHDGLRDGYPHISADFKFLSMAQPSFAGQDDPE 95 Query: 120 WKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVI 178 IRR + + ++ +Q+ L++ + P D L P VI Sbjct: 96 HGRIRRMVTLPFTARRI--EAMRPAIQKITDELIDGMLAGP-KPVDLVEALALPVPVRVI 152 Query: 179 CSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKL-LKNV 237 C ++ Y+D++FL Q NN D G K + Sbjct: 153 CEMLG---VPYEDREFL------------------QQNNNAMIYRDTAQGDAQKAAIAQA 191 Query: 238 AFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGA 297 ++K + K+ + D + +++E E T + + L GA Sbjct: 192 MYLKELVGTKLGDR--------GDDILSDLAVQVEA------GEITQDDAAGIGMMLLGA 237 Query: 298 GTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQR 357 G ETT+ + L LL++PE A+V++ + + N V E+ R Sbjct: 238 GHETTANMIALGTLALLENPEQLAEVRDSDDPKVIVN----------------TVEELLR 281 Query: 358 YIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPN-PEMFDPHHFLDEG 416 Y+ + ++ DI+ +I G I+ L + D +P P+ D H Sbjct: 282 YLTIAQDTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPDLYPEAPDRLDIHR----- 336 Query: 417 GNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTP----- 471 ++ + F G C+G LA +EL + +++L+ +L LD P Sbjct: 337 ---ANARRHLAFGYGVHQCLGATLARVELQIVYSTLLRRIPTLALAG--TLDEIPFKHDQ 391 Query: 472 VVNGFASVP 480 + +G +P Sbjct: 392 IAHGVYELP 400 >3WVS-A nrPDB Length = 401 Score = 201 bits (512), Expect = 5e-52, Method: Composition-based stats. Identities = 69/415 (16%), Positives = 136/415 (32%), Gaps = 67/415 (16%) Query: 71 LKPIVVLHGYEAVKEAL--IDLGEEFSGRGIFPLAERAN-RGFGIVFSNGKKWKEIRRFS 127 +P + YE + L S P A + N + + + +RR Sbjct: 46 GEPAWLATRYEDARLVLGDARFSRALSEEHDPPRARKFNAQAKSMFNMDAPDHTRLRRLI 105 Query: 128 LMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFHKR 186 + +V + A L++++ K P D P VIC ++ Sbjct: 106 SKAFTI--RRVEELRPKVHDLAHRLIDDMLA-KGEPADLVADYALPIPTTVICELLG--- 159 Query: 187 FDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILE 246 ++D++ F D T + + ++ Sbjct: 160 VPFEDRE------------------------KFGRWTDAILSTSTLNPEEGRVKRMELVG 195 Query: 247 KVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTL 306 + + D I + E + + T + L + + L AG ETT++ + Sbjct: 196 YIGGIIAARRAQPADDLISGMI-----EARDVQDKLTEQELLDHCIGLLIAGHETTASQI 250 Query: 307 RYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP-TS 365 + LL P+ ++ ++ E + + V E+ R++ L ++ Sbjct: 251 PSFVYALLDQPQHWKRLLDDPELI------------------PSAVEELFRFVPLGSGSA 292 Query: 366 LPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYF 425 P DI+ L+ G +L++L + D F +PE S + Sbjct: 293 APRYAREDIEVGGTLVRAGEPVLVALGAANRDGLRFEDPEEIKLDR---------PSNHH 343 Query: 426 MPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 480 + F G C+G LA +EL L ++L+ + + +V G S+P Sbjct: 344 IGFGHGIHHCLGAPLARLELQEALRALLERLPTLKVAGDIAWKSEMMVRGPRSMP 398 >2ZBZ-A nrPDB Length = 412 Score = 201 bits (511), Expect = 6e-52, Method: Composition-based stats. Identities = 80/444 (18%), Positives = 145/444 (32%), Gaps = 79/444 (17%) Query: 50 ISKSLTNLSKVYGPVFTLYF-GLKPIVVLHGYEAVKEALIDLGEEFSGR--GIFPLAERA 106 + L GP+ + + V+ +EA ++ L D S R FP A Sbjct: 26 LPDGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLS-SNRTDDNFPATSPA 84 Query: 107 NRG-----FGIVFSNGKKWKEIRRFSLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTK 160 + + + RR MT+ F + + + + V+E ++E+ Sbjct: 85 FEAVRESPQAFIGLDPPEHGTRRR---MTISEFTVKRIKGMRPEVEEVVHGFLDEMLA-A 140 Query: 161 ASPCDPTFILGC-APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNF 219 D P VIC ++ Y D +F Sbjct: 141 GPTADLVSQFALPVPSMVICRLLG---VPYADHEF------------------------- 172 Query: 220 SPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQP 279 F +L+++ + + Q L+ Sbjct: 173 ------FQDASKRLVQSTDAQSALTARNDLAGYLDGLITQFQTEPGAGLVGALVADQLAN 226 Query: 280 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339 E E L +TA+ L AG ETT++ +++ LL HPE A ++ + V G Sbjct: 227 GEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSLVPG------- 279 Query: 340 QDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNK 399 V E+ RY+ + + T DI+ LI G +++ + D Sbjct: 280 -----------AVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRDGT 328 Query: 400 EFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLK 459 + +P+ D H +++ + F G C+G+ LA +EL + L +++ Sbjct: 329 VYEDPDALDIHR---------SARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTL 379 Query: 460 SLVDPKN---LDTTPVVNGFASVP 480 L P L + G +P Sbjct: 380 RLAVPVEQLVLRPGTTIQGVNELP 403 >3A50-A nrPDB Length = 411 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 76/441 (17%), Positives = 136/441 (30%), Gaps = 73/441 (16%) Query: 48 KDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID----LGEEFSGRGIFPLA 103 ++ + L PV L P+ +L Y V+EA +D Sbjct: 20 QNPHPAYAALR-AEDPVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHRLPEDQRAD 78 Query: 104 ERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASP 163 A ++ + +R+ + M +E R+ E A L+ L P Sbjct: 79 MPATPTPMMILMDPPDHTRLRKLVGRSFTVRRM--NELEPRITEIADGLLAGLPTD--GP 134 Query: 164 CDPTFILGCA-PCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPI 222 D P VIC ++ D D S W + + SP Sbjct: 135 VDLMREYAFQIPVQVICELLGLPAEDRDD-----------------FSAWSSVLVDDSPA 177 Query: 223 IDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEF 282 D + + Y+ + ++ + D D L + Sbjct: 178 DD--------KNAAMGKLHGYLSDLLERKRTEPD--------DALLSSLLAVSDMDGDRL 221 Query: 283 TIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDR 342 + E L A+ L AG ETT + +L LL HP+ + E+ + Sbjct: 222 SQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPDQRKLLAEDPSLI------------ 269 Query: 343 SHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFP 402 + V E R+ + + D+ + IP G +++ L + D P Sbjct: 270 ------SSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMP 323 Query: 403 NPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLV 462 P+ D + + F G C+G LA +E + + + + +L Sbjct: 324 EPDRLDITR---------DASGGVFFGHGIHFCLGAQLARLEGRVAIGRLFADRPELALA 374 Query: 463 ---DPKNLDTTPVVNGFASVP 480 D + +V G + +P Sbjct: 375 VGLDELVYRRSTLVRGLSRMP 395 >4KPA-A nrPDB Length = 494 Score = 198 bits (503), Expect = 5e-51, Method: Composition-based stats. Identities = 86/443 (19%), Positives = 161/443 (36%), Gaps = 36/443 (8%) Query: 31 PGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDL 90 P P + N+ + ++L ++ G +F + L +KEA Sbjct: 30 PQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEA---C 86 Query: 91 GEEFSGRGIFPLAERA--NRGFGIVFS--NGKKWKE-----IRRFSLMTLRNF-GMGKRS 140 E + + + G G+ S + K WK+ + FS ++ + M Sbjct: 87 DESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDI 146 Query: 141 IEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEK 200 VQ+ R +E P D T + + I F+ RF + + + Sbjct: 147 AVQLVQKWERLNADE---HIEVPEDMTRL----TLDTIGLCGFNYRF---NSFYRDQPHP 196 Query: 201 LNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNP 260 ++ + +P + + +++ M + + + + + S + + Sbjct: 197 FITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQS-- 254 Query: 261 QDFIDCFLMKMEKEKHNQ-PSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEV 319 D L M K + E++ + AG ETTS L +AL L+K+P V Sbjct: 255 ----DDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHV 310 Query: 320 TAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRN- 378 K EE RV+ + P + + Y V++E R P + D Sbjct: 311 LQKAAEEAARVL-VDPVPSYKQVKQLKYVGMVLNEALRLWPTAP-AFSLYAKEDTVLGGE 368 Query: 379 YLIPKGTTILISLTSVLHDNKEF-PNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVG 437 Y + KG +++ + + D + + E F P F E + F PF G+R C+G Sbjct: 369 YPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERF--ENPSAIPQHAFKPFGNGQRACIG 426 Query: 438 EALAGMELFLFLTSILQNFNLKS 460 + A E L L +L++F+ + Sbjct: 427 QQFALHEATLVLGMMLKHFDFED 449 >2Z36-A nrPDB Length = 413 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 77/446 (17%), Positives = 143/446 (32%), Gaps = 80/446 (17%) Query: 50 ISKSLTNLSKVYGPV--FTLYFGLKPIVVLHGYEAVKEALID-------LGEEFSGRGIF 100 + L + P+ L G + + G+E + L D + F + Sbjct: 24 PPAAYERLRER-APINKVRLTSGGQ-AWWVSGHEEARAVLADGRFSSDKRKDGFPLFTLD 81 Query: 101 PLAERANRGFGIVFS--NGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRK 158 + R + +G + RR + + ++ R+Q+ ++++ Sbjct: 82 AATLQQLRSQPPLMLGMDGAEHSAARRPVIGEFTVKRLA--ALRPRIQDIVDHFIDDMLA 139 Query: 159 TKASPCDPTFILGC-APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICN 217 T P D L P VIC ++ Y D F + + + Sbjct: 140 TDQRPVDLVQALSLPVPSLVICELLG---VPYTDHDFFQSRTTMMVSRTSMED------- 189 Query: 218 NFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHN 277 + A +++YI + + + + P D L + + Sbjct: 190 ---------------RRRAFAELRAYIDDLI-----TRKESEPGDD----LFSRQIARQR 225 Query: 278 QPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSP 337 Q L + A L AG ETT+ + ++ LL HPE V+ R Sbjct: 226 QEGTLDHAGLVSLAFLLLTAGHETTANMISLGVVGLLSHPEQLTVVKANPGR-------- 277 Query: 338 CMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHD 397 T V E+ RY + T D++ I G +++S+ S D Sbjct: 278 ----------TPMAVEELLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWD 327 Query: 398 NKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFN 457 F +P + D +++ + F G C+G+ LA MEL + ++ + Sbjct: 328 PAVFKDPAVLDVER---------GARHHLAFGFGPHQCLGQNLARMELQIVFDTLFRRIP 378 Query: 458 LKSLVDPKN---LDTTPVVNGFASVP 480 L P V+ G +P Sbjct: 379 SLRLAVPMEDVPFKGDSVIYGVHELP 404 >5L94-A nrPDB Length = 410 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 71/414 (17%), Positives = 136/414 (32%), Gaps = 65/414 (15%) Query: 72 KPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTL 131 + + + Y+ VKE L S R + G ++ + K E+R Sbjct: 44 RQVWDVFHYDGVKEVLEQKNIFSSDRRPPQNQRQTALGTSLINIDPPKHAEMRALVNKAF 103 Query: 132 RNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIF---HKRF 187 M ++ E ++ L++E D L P VI I+ + Sbjct: 104 TPKAM--KAWEPKIARITNELLQE--VEHLEDIDIVEHLSYPLPVMVIADILGVPIEDQR 159 Query: 188 DYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEK 247 +KD + + N + L + +K +++Y Sbjct: 160 QFKDWSDIIVAGPSNNERETLEKL------------------QQEKMKANDELETYFYRI 201 Query: 248 VKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLR 307 ++E + P D I L++ ++E + T E + ++ L AG ETT+ + Sbjct: 202 IEEKR-----TRPGDDIISVLLQAKEE----GKQLTDEEIVGFSILLLIAGNETTTNLIS 252 Query: 308 YALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLP 367 + L++ +++ E E + + EV RY + +L Sbjct: 253 NTIYCLMEDKASFERLKREKE------------------LLPSGIEEVLRYRSPVQ-ALH 293 Query: 368 HAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMP 427 V D+ + G ++ + S D + F +PE+F K M Sbjct: 294 RIVKEDVTLAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFKIDR---------KPNVHMA 344 Query: 428 FSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDT--TPVVNGFASV 479 F G C+G LA +E + L ++ + L + V G + Sbjct: 345 FGRGIHFCLGAPLARIEAKIMLAELIDRYPQMDWSPSFELKPIESTFVYGLKEL 398 >4TX3-A nrPDB Length = 404 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 80/418 (19%), Positives = 139/418 (33%), Gaps = 78/418 (18%) Query: 62 GPVFTLYFGL----KPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIV---F 114 G + + G + + G+ V++ L D + FS R F + G G+ Sbjct: 32 GTLTKISIGSGADAETTWLAAGHAVVRQVLGDH-KRFSTRRRFDRRDEI-GGTGVFRPRE 89 Query: 115 SNGKKW----KEIRRFSLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPCDPTFI 169 G E R + F + R + R++E ++ + P D + Sbjct: 90 LVGNLMDYDPPEHTRLRHLLTPGFTQRRMRRLAPRIEEIVTDRLDAME-QAGPPADLIEL 148 Query: 170 L-GCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPG 228 P V+C +I DQ ++Q+C+ +D Sbjct: 149 FADEVPGAVLCELIG---VPRDDQAM-----------------FLQLCHRH---LDASLS 185 Query: 229 THNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLE 288 + AF + + +E + D D F+ + E T E L Sbjct: 186 ARKRAAAGEAFARYLVAMMARERK---------DPGDGFIGSIVAEH---GDTITDEELR 233 Query: 289 NTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYT 348 V L AG + S + +L LL+HPE A ++ + + Sbjct: 234 GVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQS------------------A 275 Query: 349 DAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFD 408 D V E+ RY+ + P D+ + +I +G T+L SL D P+ + D Sbjct: 276 DRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLD 335 Query: 409 PHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKN 466 + F G C+G AL ++L + T++ + F L DP Sbjct: 336 VTR---------TPVPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPAQ 384 >4UBS-A nrPDB Length = 393 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 76/423 (17%), Positives = 148/423 (34%), Gaps = 81/423 (19%) Query: 71 LKPIVVLHGYEAVKEALIDLGEEFSGR--GIFPLAE-----RANRGFGIVFSNGKKWKEI 123 + + V+ G+ A + L D S R FP R ++ + + + Sbjct: 36 GRSVWVVTGHAAARALLSDQRLS-SDRTLPRFPATTERFEAVRTRRVALLGVDDPEHRTQ 94 Query: 124 RRFSLMTLRNFGMGKRS-IEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSI 181 RR M + +F + + + + R+QE L++ + + P + P VIC++ Sbjct: 95 RR---MLVPSFTLKRAAALRPRIQETVDGLLDAMEA-QGPPAELVSAFALPLPSMVICAL 150 Query: 182 IFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNV-AFM 240 + Y D F S G +++ A + Sbjct: 151 LG---VPYADHDFFE-----------------------SQSRRLLRGPGIAEVQDARAQL 184 Query: 241 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 300 Y+ + ++ + D L + +E+ N+ + L + A L AG E Sbjct: 185 DDYLYALIDRKRK--------EPGDGLLDDLIQEQLNRGT-VDRAELVSLATLLLIAGHE 235 Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360 TT+ + LL+HPE A+++ E A V E+ R++ Sbjct: 236 TTANMISLGTFTLLRHPEQLAELRAEPG------------------LMPAAVEELLRFLS 277 Query: 361 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 420 + L T DI+ I ++ + + + D F P+ D H Sbjct: 278 IA-DGLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALDWHR--------- 327 Query: 421 KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKN-LDTTP--VVNGFA 477 +++ + F G C+G+ LA E+ + L ++ + L P + + P + G Sbjct: 328 SARHHVAFGFGIHQCLGQNLARAEMEIALGTLFERLPGLRLAAPADEIPFKPGDTIQGML 387 Query: 478 SVP 480 +P Sbjct: 388 ELP 390 >4WPZ-A nrPDB Length = 397 Score = 196 bits (498), Expect = 2e-50, Method: Composition-based stats. Identities = 75/423 (17%), Positives = 150/423 (35%), Gaps = 85/423 (20%) Query: 75 VVLHGYEAVKEALIDLGEEFSGRGIFPLAERAN-------RGFGIVFSNGKKWKEIRRFS 127 ++ + V++ L+D FS + + A + +V + + +R+ Sbjct: 40 WMVTKHADVRKVLVD--SRFSSKVMATAAAAMSETETGKLMNESLVGMDAPEHTRLRKLV 97 Query: 128 LMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFHKR 186 ++ R+ E L++EL P D P VIC ++ Sbjct: 98 TKAFT--ARRVETLRPRITELVGQLLDELETLP-RPVDLVKNFSVPLPVRVICELLG--- 151 Query: 187 FDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAF---MKSY 243 DQ + F + G ++++ A + +Y Sbjct: 152 VPAGDQ------------------------DTFHAWSNALLGDWQQVVEKEAATVSLVNY 187 Query: 244 ILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTS 303 E + ++ NP D + L+ + + S T + ++ + AG ETT+ Sbjct: 188 FGELI-----AVKRENPADDLISELIAI----SDGDSTLTEREIIALSIGILSAGHETTA 238 Query: 304 TTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP 363 + L+ LL +PE K+++ E + V E+ R++ L Sbjct: 239 NQISMFLVTLLHNPEELDKLRDNREAI------------------PKAVDELLRFVPLTT 280 Query: 364 TS--LPHAVTCDIKF-RNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 420 T +P T +++ ++P G +L ++ + D + F + E + Sbjct: 281 TGGIIPRLTTAEVELSGGQVLPAGAVVLPAVATANRDPEVFEDGERLNVTR--------- 331 Query: 421 KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPK---NLDTTPVVNGFA 477 ++ + F AG C+G LA +EL L +IL L P+ L + ++ G Sbjct: 332 ENNPHLAFGAGIHHCLGAQLARIELQEALGAILDRMPQVRLAVPESELRLKSASIIRGLE 391 Query: 478 SVP 480 S+P Sbjct: 392 SLP 394 >4Z5P-A nrPDB Length = 400 Score = 195 bits (495), Expect = 4e-50, Method: Composition-based stats. Identities = 76/460 (16%), Positives = 150/460 (32%), Gaps = 88/460 (19%) Query: 36 LPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYF-GLKPIVVLHGYEAVKEALIDLGEEF 94 P G ++ +I L + P+ + ++ Y+ V+ A + F Sbjct: 11 YPFEG---EVDGLEIHPKFAELRET-DPLARVRLPYGGEGWMVTRYDDVRAA--NSDPRF 64 Query: 95 S----GRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEAR 150 S G A R I+ + + +RR MG +++ ++E Sbjct: 65 SRAQIGEDTPRTTPLARRSDTILSLDPPEHTRLRRLLSKAFTARRMG--AMQSWLEELFA 122 Query: 151 CLVEELRKTKASPCDPTFILGC-APCNVICSIIF-----HKRFDYKDQQFLNLMEKLNEN 204 L++ + +T P D L VIC ++ RF + + ++ E Sbjct: 123 GLLDGVERT-GHPADIVRDLAQPFTIAVICRLLGVPYEDRGRFQHWSEVIMSTTAYSKE- 180 Query: 205 IKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFI 264 + + A +++Y+ + V + + P D Sbjct: 181 ---------------------------EAVSADASIRAYLADLVSARRAA-----PHDD- 207 Query: 265 DCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQ 324 L+ + + T + L V L AG ET++ L + LL H + + ++ Sbjct: 208 ---LLGVLVSARDDDDRLTEDELITFGVTLLVAGHETSAHQLGNMVYALLTHEDQLSLLR 264 Query: 325 EEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLL-PTSLPHAVTCDIKFRNYLIPK 383 E+ E V E+ R++ L D++ + Sbjct: 265 EQPE------------------LLPRAVEELLRFVPLGNGVGNARIALEDVELSGGTVRA 306 Query: 384 GTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGM 443 G ++ + + D + F +P+ D + + F G C+G LA M Sbjct: 307 GEGVVAAAVNANRDPRAFDDPDRLDITR---------EKNPHLAFGHGAHYCLGAQLARM 357 Query: 444 ELFLFLTSILQNFNLKSLVDPKN---LDTTPVVNGFASVP 480 EL + + +L+ F L P + T + G +P Sbjct: 358 ELRVAIGGLLERFPGLRLAVPADQVEWKTGGLFRGPQRLP 397 >6FSH-A nrPDB Length = 398 Score = 192 bits (487), Expect = 4e-49, Method: Composition-based stats. Identities = 78/418 (18%), Positives = 139/418 (33%), Gaps = 78/418 (18%) Query: 62 GPVFTLYFGL----KPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIV---F 114 G + + G + + G+ V++ L D ++FS R + + G GI Sbjct: 26 GTLTKISIGSGADAETTWLAAGHAVVRQVLGDH-QQFSTRRRWDPRDEI-GGKGIFRPRE 83 Query: 115 SNGKKW----KEIRRFSLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPCDPTFI 169 G E R + F + R + R++E ++ + P D + Sbjct: 84 LVGNLMDYDPPEHTRLRHLLTPGFTQRRMRRLAPRIEEIVTDRLDAME-QAGPPADLIEL 142 Query: 170 L-GCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPG 228 P V+C +I R D ++++C+ +D Sbjct: 143 FADEVPGAVLCELIGVPRDDRD--------------------MFMKLCHGH---LDASLS 179 Query: 229 THNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLE 288 + F + + +E + D D F+ + E T E L Sbjct: 180 QKRRAALGDKFSRYLLAMIARERK---------DPGDGFIGSIVAEH---GDTITDEELR 227 Query: 289 NTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYT 348 V L AG + S + +L LL+HPE A ++ + + Sbjct: 228 GVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQS------------------A 269 Query: 349 DAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFD 408 D V E+ RY+ + P D+ + +I +G T+L SL D P+ + D Sbjct: 270 DRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLD 329 Query: 409 PHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKN 466 + F G C+G AL ++L + T++ + F L DP Sbjct: 330 VTR---------TPVPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPAQ 378 >3ABB-A nrPDB Length = 408 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 84/434 (19%), Positives = 152/434 (35%), Gaps = 77/434 (17%) Query: 58 SKVYGPVFTLYFG-LKPIVVLHGYEAVKEALID-LGEEFSGRGIFPLAERANRGFG---- 111 + P+ + +P ++ G+ + L+D G FP+ R G Sbjct: 33 RRGESPLTQVTLFDGRPAWLITGHAEGRALLVDPRLSSDWGHPDFPVVVRRTEDRGGLAF 92 Query: 112 -IVFSNGKKWKEIRRFSLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPCDPTFI 169 ++ + RR M + +FG+ + +I R+Q L++++ K D Sbjct: 93 PLIGVDDPVHARQRR---MLIPSFGVKRMNAIRPRLQSLVDRLLDDMLA-KGPGADLVSA 148 Query: 170 LGCAPCNV-ICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPG 228 +V IC ++ Y D F + + NF Sbjct: 149 FALPVPSVAICELLG---VPYGDHDF-----------------FEECSRNFVGAA----- 183 Query: 229 THNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLE 288 T + + +Y+ V Q P+D + L+ + E+ + + + Sbjct: 184 TSAEADAAFGELYTYLHGLVGRKQA-----EPEDGLLDELIARQLEE----GDLDHDEVV 234 Query: 289 NTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYT 348 A+ L AG ETT + L L++HPE + + V G Sbjct: 235 MIALVLLVAGHETTVNAIALGALTLIQHPEQIDVLLRDPGAVSG---------------- 278 Query: 349 DAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFD 408 VV E+ R+ + + DI+ I G +L+S+T + D K + NP++FD Sbjct: 279 --VVEELLRFTSVSDHIV-RMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDIFD 335 Query: 409 PHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLD 468 +++ + F G C+G+ LA EL + L + L P LD Sbjct: 336 ARR---------NARHHVGFGHGIHQCLGQNLARAELEIALGGLFARIPGLRLAVP--LD 384 Query: 469 TTPVVNGFASVPPF 482 P+ G + P Sbjct: 385 EVPIKAGHDAQGPI 398 >3R9C-A nrPDB Length = 418 Score = 189 bits (480), Expect = 3e-48, Method: Composition-based stats. Identities = 63/392 (16%), Positives = 129/392 (32%), Gaps = 55/392 (14%) Query: 89 DLGEEFSGRGIFPLAERANRG-FGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQE 147 R + + +G +F + +R + + +E + Sbjct: 73 RTKSTIFQRQLAAETQPRPQGPASFLFLDPPDHTRLRGLVSKAFAPRVI--KRLEPEITA 130 Query: 148 EARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKI 207 L++ + + + D + P VIC ++ D +F L + Sbjct: 131 LVDQLLDAVDGPEFNLID--NLAYPLPVAVICRLLGVPIEDE--PKFSRASALLAAALDP 186 Query: 208 LSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCF 267 + + + F ++ +K +++ Y+ + E + + P + + Sbjct: 187 FLALTGETSDLF-----------DEQMKAGMWLRDYLRALIDERRRT-----PGEDLMSG 230 Query: 268 LMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEI 327 L+ +E+ + T + + T L AG ETT + A L +L+ P A + + Sbjct: 231 LVAVEES----GDQLTEDEIIATCNLLLIAGHETTVNLIANAALAMLRTPGQWAALAADG 286 Query: 328 ERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTI 387 R AV+ E RY + + D+ + +PKG T+ Sbjct: 287 SR------------------ASAVIEETMRYDPPVQL-VSRYAGDDLTIGTHTVPKGDTM 327 Query: 388 LISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFL 447 L+ L + D P+ FDP + F G C+G LA +E + Sbjct: 328 LLLLAAAHRDPTIVGAPDRFDPDR---------AQIRHLGFGKGAHFCLGAPLARLEATV 378 Query: 448 FLTSILQNFNLKSLVDPKNLDTTPVVNGFASV 479 L ++ F L + G +++ Sbjct: 379 ALPALAARFPEARLSGEPEYKRNLTLRGMSTL 410 >4YZR-A nrPDB Length = 405 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 64/368 (17%), Positives = 127/368 (34%), Gaps = 65/368 (17%) Query: 116 NGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPC 175 + +R + ++ +++ A L++E+ K + P Sbjct: 95 DTPDHTRLRSLVHQAFTPRTI--ENLRGSIEQIAEQLLDEMEKENKADI-MKSFASPLPF 151 Query: 176 NVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLK 235 VI ++ + D +I ++ ++D G + Sbjct: 152 IVISELMGIPKEDRSQ-------------FQIWTNA----------MVDTSEGNRELTNQ 188 Query: 236 NVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLF 295 + K YI + + + + P+D + L+ E+ S+ + + L + L Sbjct: 189 ALREFKDYIAKLIHDRRIK-----PKDDLISKLVHAEE----NGSKLSEKELYSMLFLLV 239 Query: 296 GAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEV 355 AG ETT L L LL+H + K++++ E + V E+ Sbjct: 240 VAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIA------------------TAVEEL 281 Query: 356 QRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDE 415 RY + D ++ + I +G I I + S D F NPE+ + + Sbjct: 282 LRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEILNINR---- 337 Query: 416 GGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFN-LKSLVDPKNLDTTPVV- 473 + F G C+G LA +E + ++L+ F ++ V P ++ V Sbjct: 338 -----SPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAPDDIQWRKNVF 392 Query: 474 -NGFASVP 480 G S+P Sbjct: 393 LRGLESLP 400 >5FOI-A nrPDB Length = 408 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 83/402 (20%), Positives = 143/402 (35%), Gaps = 74/402 (18%) Query: 71 LKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFG---IVFSNGKKWKEIRRF- 126 P ++ YE V+ L+D L+E G G ++ + + +RR Sbjct: 55 GSPTWLVSRYEHVRALLVDPRVTVDPTRQPRLSEADGDGDGFRSMLMLDPPEHTRLRRMF 114 Query: 127 -SLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFH 184 S ++R + IE V L+ P D L VIC ++ Sbjct: 115 ISAFSVRQVETMRPEIEKIVDGILDRLLA-----LEPPVDILTHLALPMSTQVICHLLG- 168 Query: 185 KRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYI 244 Y+D++F E ++ S P ++ + + + Y+ Sbjct: 169 --VPYEDREF------FQERSELASRP-----------------NDDRSMPALIELVEYL 203 Query: 245 LEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTST 304 V+ D L+ + E T + L N AV L AG ET++ Sbjct: 204 DGLVRTKTAHP---------DTGLLGTAVTERLLKGEITHQELVNNAVLLLAAGHETSAN 254 Query: 305 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPT 364 + ++L LL+HPE A+++E+ E V E+ RY + Sbjct: 255 QVTLSVLTLLRHPETAAELREQPE------------------LMPNAVDELLRYHSIA-D 295 Query: 365 SLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKY 424 L A T DI ++ I G ++I L+S HD F FD H +++ Sbjct: 296 GLRRAATADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATFDIHR---------PARH 346 Query: 425 FMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKN 466 + F G C+G+ LA +E+ + L + + L + Sbjct: 347 HVAFGYGPHQCLGQNLARLEMEVTLGKLFRRVPALRLAQEPD 388 >6A7J-A nrPDB Length = 411 Score = 188 bits (478), Expect = 4e-48, Method: Composition-based stats. Identities = 78/432 (18%), Positives = 143/432 (33%), Gaps = 84/432 (19%) Query: 62 GPVFTLYF-GLKPIVVLHGYEAVKEALID--------------LGEEFSGRGIFPLAERA 106 GP+ + G + + ++ + L D GE +PL Sbjct: 26 GPLAEVELPGGVHVYAVTHHKEARALLTDSRVVKDINVWNAWQRGEI---PADWPLIGLV 82 Query: 107 NRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKT-KASPCD 165 N G ++ +G + +R L + K + ++ +E L P D Sbjct: 83 NPGRSMLTVDGPDHRRLRTLVAQALTVKRVEK--LRAGIEALTNASLERLAALPAGEPVD 140 Query: 166 PTFILGC-APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIID 224 P NVI ++ D+ L E + Sbjct: 141 LKAEFAYPLPMNVISELMGVDAADHP-----RLKELFEKFFST----------------- 178 Query: 225 YFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTI 284 ++ + +A + + + V+E + NP D + L+ T Sbjct: 179 --QTPPEEVPQMMADLGTLFTKIVEEKKA-----NPGDDLTSALIAA----SEDGDHLTD 227 Query: 285 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSH 344 E + NT + AG ETT + + + L HPE KV Sbjct: 228 EEILNTLQLIIAAGHETTISLIVNVVEALAIHPEQRKKVLS-----------------GE 270 Query: 345 MPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEF-PN 403 +P+ + V+ E R+ L T DI+ + ++PKG +++S ++ D +++ P Sbjct: 271 IPW-EGVIEETLRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDEEQYGPT 329 Query: 404 PEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVD 463 FD + + F G +C G AL+ +E + L ++ + F L Sbjct: 330 AGDFD---------ATRTPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAV 380 Query: 464 P-KNLDTTPVVN 474 P L P+V Sbjct: 381 PAAELRNKPIVT 392 >5YSW-A nrPDB Length = 441 Score = 187 bits (474), Expect = 1e-47, Method: Composition-based stats. Identities = 79/448 (17%), Positives = 157/448 (35%), Gaps = 82/448 (18%) Query: 50 ISKSLTNLSKVYGPVFTLYFG-LKPIVVLHGYEAVKEALIDLG------------EEFSG 96 + +L +S+ GPV P ++ GYE + L D +E S Sbjct: 53 VPPALVAVSER-GPVARATLAAGDPFWLVSGYEEARAVLSDPRFSSDRFQYHPWFKELSP 111 Query: 97 RGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEEL 156 L + R + + + R+ + R + R+ E V+ + Sbjct: 112 EFRERLRDDKARAGSFINMDPPEHTRYRKLLTGQFTVRRI--RELGARIDEIVAGRVDAM 169 Query: 157 RKTKASPCDPTFILGC-APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQI 215 + D AP +IC ++ Y+D+ + +S +Q+ Sbjct: 170 LA-GGTTADLMTEFAFPAPSLMICELLG---VRYEDRA----------EFQQRASALLQM 215 Query: 216 CNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEK 275 + +KN +++++ V + + N D I + + Sbjct: 216 NA-----------PVAEAVKNADALRAFMQALVTDKR----ANPAGDIISGLIHHAGADP 260 Query: 276 HNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNR 335 T + L N A L AG +TT++ L + +LL+ P A ++++ R+ Sbjct: 261 A-----LTDDELINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDDPSRIAD--- 312 Query: 336 SPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVL 395 V E+ RY+ ++ + D++F IP G+T+++S+ + Sbjct: 313 ---------------AVEELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATN 357 Query: 396 HDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQN 455 D + +P+P++ + + F G C+G+ LA ME+ +L+ Sbjct: 358 RDARHWPDPDL----------DLTRPRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRR 407 Query: 456 FNLKSLVDPKN---LDTTPVVNGFASVP 480 L P L + G S+P Sbjct: 408 LPNVRLAVPPEEVPLRNDMLTYGVHSLP 435 >3SN5-A nrPDB Length = 491 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 87/499 (17%), Positives = 168/499 (33%), Gaps = 68/499 (13%) Query: 19 LWRQSSGRGKL---PPGPTPL-PVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPI 74 + +++S R + PP L P +G LQ G + + L + +G VFT K + Sbjct: 1 MAKKTSSRRRQTGEPPLENGLIPYLGCALQFG-ANPLEFLRANQRKHGHVFTCKLMGKYV 59 Query: 75 VVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNF 134 + + + L G+ F + F + + + I T N Sbjct: 60 HFITNPLSYHKVLC-HGKYF---------DWKKFHFALS-AKAFGHRSIDPMDGNTTENI 108 Query: 135 GM-GKRSIEDR-VQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQ 192 ++++ + ++E L++ P + S + F+ Sbjct: 109 NDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAG-- 166 Query: 193 QFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFP----GTHNKLLKNVAFMKSYILEKV 248 +L + + + + +NF FP G + + + + E + Sbjct: 167 -YLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESL 225 Query: 249 KEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRY 308 + H+ + + I + ++ S F T + + A T + Sbjct: 226 R-HENLQKRESISELISLRMFL-----NDTLSTFDDLEKAKTHLVVLWASQANTIPATFW 279 Query: 309 ALLLLLKHPEVTAKVQEEIERVI----------GRNRSPCMQDRSHMPYTDAVVHEVQRY 358 +L ++++PE EE++R + G + + +P D+++ E R Sbjct: 280 SLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRL 339 Query: 359 IDLLPTSLPHAVTCDIKF----RNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLD 414 D +Y I K I + + D + +P+P F +LD Sbjct: 340 SSASLNI--RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLD 397 Query: 415 EGGNFKKS---------KYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPK 465 E G K + Y+MPF +G IC G A E+ FL +L F L+ Sbjct: 398 ENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELE------ 451 Query: 466 NLDTTPVVNGFASVPPFYQ 484 ++ G A PP Q Sbjct: 452 ------LIEGQAKCPPLDQ 464 >3TYW-A nrPDB Length = 417 Score = 186 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 84/414 (20%), Positives = 149/414 (35%), Gaps = 75/414 (18%) Query: 63 PVFTLYFGLKP-IVVLHGYEAVKEALID-LGEEFSGRGIFPLAERANRGFGIVF-----S 115 PV + + V+ Y+ V+E L D R FP + G F + Sbjct: 43 PVARVTLPTRREAWVVTRYDDVRELLSDPRVSADIRRPGFPALGEGEQEAGARFRPFIRT 102 Query: 116 NGKKWKEIRRFSL--MTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCA 173 + + RR L T+R + +++ RV E ++ P D A Sbjct: 103 DAPEHTRYRRMLLPAFTVRRVRAMRPAVQARVDEILDGMLAA-----GGPVDLVSAYANA 157 Query: 174 P-CNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNK 232 +VIC ++ R D +E + +I S T + Sbjct: 158 VSTSVICELLGIPRHD---------LEFFRDVTRISGSRN---------------STAEQ 193 Query: 233 LLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAV 292 + + + + + V E +E P+D + L+ H P T E L +T Sbjct: 194 VSEALGGLFGLLGGLVAERRE-----EPRDDLISKLV----TDHLVPGNVTTEQLLSTLG 244 Query: 293 DLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVV 352 AG ETT++ + + LLLL PE+ A+++++ + A V Sbjct: 245 ITINAGRETTTSMIALSTLLLLDRPELPAELRKDPD------------------LMPAAV 286 Query: 353 HEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHF 412 E+ R + + + DI+ +P ++ L HD ++F +PE D H Sbjct: 287 DELLRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHR- 345 Query: 413 LDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKN 466 + + F G CVG+ LA +EL + L ++L+ L ++ Sbjct: 346 --------TDNHHVAFGYGVHQCVGQHLARLELEVALETLLRRVPTLRLAGERD 391 >5IT1-A nrPDB Length = 399 Score = 186 bits (471), Expect = 3e-47, Method: Composition-based stats. Identities = 66/418 (15%), Positives = 137/418 (32%), Gaps = 71/418 (16%) Query: 71 LKPIVVLHGYEAVKEALID----LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRF 126 ++ GYE V+ L D +G + + + +++ + + + R+ Sbjct: 42 GHEAWLVTGYEQVRAVLRDPSFSVGVPHALHTQDGVVTQKPGRGSLLWQDAPEHTDDRK- 100 Query: 127 SLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHK 185 + + F + + +++ +Q ++ + + P D +++ S +F Sbjct: 101 --LLAKEFTVRRMQALRPNIQRIVDEHLDAIEA-RGGPVDLVKTFANPVPSMVISDLFGV 157 Query: 186 RFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYIL 245 + + +F + E + + ++ + + Sbjct: 158 PAERRA-EFQEIAEAMMRVDQDAAATEA----------------------AGMRLGGLLY 194 Query: 246 EKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTT 305 + V+E + NP D + L+ E + L N A L A +TT+ Sbjct: 195 QLVQERRA-----NPGDDLISALITTE----DPDGVIDDMFLMNAAGTLLIAAHDTTACM 245 Query: 306 LRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTS 365 + LLL P+ A +Q++ + V E+ RY+ + Sbjct: 246 IGLGTALLLDRPDQLALLQKDPSLI------------------GNAVEELLRYLTIGQFG 287 Query: 366 LPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYF 425 T D + I KG ++ L S D +PE FD + Sbjct: 288 AERVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPERFDITR---------RPAPH 338 Query: 426 MPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDP---KNLDTTPVVNGFASVP 480 + F G C+G+ LA +EL + ++ + F L P V G +P Sbjct: 339 LAFGFGAHQCIGQQLARIELQIVFGTLFRRFPTLRLAKPVEELRFRNDMVFYGVHELP 396 >6GMF-A nrPDB Length = 397 Score = 185 bits (470), Expect = 3e-47, Method: Composition-based stats. Identities = 79/419 (18%), Positives = 144/419 (34%), Gaps = 66/419 (15%) Query: 68 YFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERA-----NRGFGIVFSNGKKWKE 122 + + + Y+ V L D + FS RG R + IV + + + Sbjct: 31 RLQPQGFMAVGRYQDVARVLHD-AKGFSNRGWAASLPRGVKWDTSMPPSIVQVDPPRHGK 89 Query: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSII 182 +R + + +E R+++ A LV+ LR + P VI ++ Sbjct: 90 LRTLVTKAFTPRTVAQ--LEPRIRDIAHELVDGLRGKSTFEAT-VEVTVPMPMIVIAEML 146 Query: 183 FHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKS 242 D F + + ++ ++ G +L ++ + Sbjct: 147 GVAPERRAD--FKRWSDDMVGSLALVRV-----------------GNAAQLERSTQEFYA 187 Query: 243 YILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETT 302 Y E + E +D I L + T + + A L AG ETT Sbjct: 188 YFSEVL----EERRREPREDLISQLLAAEV-----DGEKLTAGEVLSFANTLLIAGNETT 238 Query: 303 STTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLL 362 ++ + AL+ L HPE A Q ++ V AVV EV RY Sbjct: 239 TSLIGNALVALTDHPEQLAAAQADLSLV------------------PAVVEEVLRYESPA 280 Query: 363 PTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS 422 + D++ + IP + +L L S D FP+P+ FD H + Sbjct: 281 QC-IFRQTMTDVEIGDERIPARSVVLPLLASANRDESRFPDPDRFDIHR---------DT 330 Query: 423 KYFMPFSAGKRICVGEALAGMELFLFLTSILQNF-NLKSLVDPKNLDTTPVVNGFASVP 480 K + F C+G LA +E + L +L +++ + + + + +++P Sbjct: 331 KGHLAFGLDIHFCIGAPLARLEAKVMLEVLLARLGDIQRVSQEVSWSPSFFIRSPSTLP 389 >4MM0-A nrPDB Length = 399 Score = 184 bits (467), Expect = 7e-47, Method: Composition-based stats. Identities = 78/418 (18%), Positives = 147/418 (35%), Gaps = 73/418 (17%) Query: 71 LKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRG--FGIVFSNGKKWKEIRRFSL 128 P ++ YE V+ L D FS R P A R ++ ++ +RR Sbjct: 44 GDPGFLVTRYEDVRFVLSD--PRFSVRQDLPGAPRLTEMTFESVMTTDPPVHTRLRR--- 98 Query: 129 MTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFHKR 186 + R+F + + R++E A L++E+ K K +P D L P VIC ++ Sbjct: 99 LLSRDFTARRIERMRPRLEEIAEGLLDEMEK-KGAPADIVESLAVPFPITVICELL---- 153 Query: 187 FDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILE 246 P + + F D +++ + + Sbjct: 154 ----------------------GVPMVDV-ARFRGWADTMVSLTGYSMEDWTAARDALES 190 Query: 247 KVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTL 306 + + N D + + ++ +E T + + ++ L AG E S L Sbjct: 191 YLDGLVAAKRENPGSDLLSALVATAAED-----NELTDHDVRSLSLILLLAGYEPASNQL 245 Query: 307 RYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSL 366 ++L LL+ P+ A+++ + + V E+ RY +L Sbjct: 246 GSSVLTLLRFPDRLAELRRDPG------------------LLPSAVEELMRYAPAGDGAL 287 Query: 367 PHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFM 426 D+ + IP + +L S + D + F +P Sbjct: 288 FRVTLEDVTIGDTHIPANSAVLASTQAANWDPRRFDDPTGLRLDR---------PDNQHT 338 Query: 427 PFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLV-DPKNLDTT---PVVNGFASVP 480 G C+G ALA +EL + + ++L+ F +L D L + +++GFA +P Sbjct: 339 ALGHGIHFCLGAALARVELQVAIGALLRRFPRLALATDESGLRWSSPGSMLSGFAEIP 396 >3ABA-A nrPDB Length = 403 Score = 184 bits (467), Expect = 8e-47, Method: Composition-based stats. Identities = 65/400 (16%), Positives = 128/400 (32%), Gaps = 66/400 (16%) Query: 71 LKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAE---RANRGFGIVFSNGKKWKEIRRFS 127 ++ GYE V+ L FS + L + G + E Sbjct: 42 GHEAWLVTGYEEVRALL--RDSSFSVQVPHALHTQDGVVTQKPGRGSLLWQDEPEHTSDR 99 Query: 128 LMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKR 186 + + F + + +++ +Q ++ + + P D A +++ S +F Sbjct: 100 KLLAKEFTVRRMQALRPNIQRIVDEHLDAIEA-RGGPVDLVKTFANAVPSMVISDLFGVP 158 Query: 187 FDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILE 246 + + +F ++ E + + ++ + + + Sbjct: 159 VERRA-EFQDIAEAMMRVDQDAAATEA----------------------AGMRLGGLLYQ 195 Query: 247 KVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTL 306 V+E + NP D + L+ E F L N A L A +TT+ + Sbjct: 196 LVQERRA-----NPGDDLISALITTEDPDGVVDDMF----LMNAAGTLLIAAHDTTACMI 246 Query: 307 RYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSL 366 LLL P+ A ++E+ V V E+ RY+ + Sbjct: 247 GLGTALLLDSPDQLALLREDPSLV------------------GNAVEELLRYLTIGQFGG 288 Query: 367 PHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFM 426 T D++ I KG ++ + + D PE FD + + Sbjct: 289 ERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITR---------RPAPHL 339 Query: 427 PFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKN 466 F G C+G+ LA +EL + ++ + L P Sbjct: 340 AFGFGAHQCIGQQLARIELQIVFETLFRRLPGLRLAKPVE 379 >1LG9-A nrPDB Length = 398 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 71/438 (16%), Positives = 146/438 (33%), Gaps = 82/438 (18%) Query: 43 LQIGIKDISKSLTNLSKVYGPVFTLYFGL----KPIVVLHGYEAVKEALIDLGEEFSGRG 98 L I + + + L+ G + + G + + + V++ + D + + R Sbjct: 9 LHIRRQGLDPADELLAA--GALTRVTIGSGADAETHWMATAHAVVRQVMGDHQQFSTRRR 66 Query: 99 IFPLAERANRG--------FGIVFSNGKKWKEIRRFSLMTLRNFGMGK-RSIEDRVQEEA 149 P E +G ++ + + +RR F + K + + +++ Sbjct: 67 WDPRDEIGGKGIFRPRELVGNLMDYDPPEHTRLRR---KLTPGFTLRKMQRMAPYIEQIV 123 Query: 150 RCLVEELRKTKASPCDP-TFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKIL 208 ++E+ + SP D F+ P V+C ++ R D Sbjct: 124 NDRLDEMER-AGSPADLIAFVADKVPGAVLCELVGVPRDDRD------------------ 164 Query: 209 SSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFL 268 ++++C+ +D + F + + +E +E + + Sbjct: 165 --MFMKLCHGH---LDASLSQKRRAALGDKFSRYLLAMIARERKEPG---------EGMI 210 Query: 269 MKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIE 328 + E + T E L V + AG + S + +L +L+HPE + + + Sbjct: 211 GAVVAE---YGDDATDEELRGFCVQVMLAGDDNISGMIGLGVLAMLRHPEQIDAFRGDEQ 267 Query: 329 RVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTIL 388 V E+ RY+ + + P D+ I KG +++ Sbjct: 268 S------------------AQRAVDELIRYLTVPYSPTPRIAREDLTLAGQEIKKGDSVI 309 Query: 389 ISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLF 448 SL + D P+ + D + + F G C+G ALA +EL Sbjct: 310 CSLPAANRDPALAPDVDRLDVTR---------EPIPHVAFGHGVHHCLGAALARLELRTV 360 Query: 449 LTSILQNFNLKSLVDPKN 466 T + + F L DP Sbjct: 361 FTELWRRFPALRLADPAQ 378 >6GK6-A nrPDB Length = 411 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 72/416 (17%), Positives = 128/416 (30%), Gaps = 80/416 (19%) Query: 76 VLHGYEAVKEALIDLGEEFSGRGIFPLAERA-NRGFGIVFSNGKKWKEIRRFSLMTLRNF 134 +L +++ + R FPL++R ++ ++ +R Sbjct: 56 LLKDPRLIRDF--RKLPDEVRRRYFPLSDRTTFMDQHMLDADPPDHTRLRAIVQRAFSP- 112 Query: 135 GMGKRSIEDRVQEEARCLVEEL--RKTKASPCDPTFILGCAPCNVICSIIF-----HKRF 187 + R+QE A L++ + R+ D F L P VI ++ RF Sbjct: 113 -RMMEGLRPRIQEIADGLIDAVIDRRRMELIADFAFPL---PTAVIAELLGLPVEDRGRF 168 Query: 188 DYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEK 247 + L P + ++ + Sbjct: 169 RRWTKILL------------------------------APAKDREFVERAQPVVEEFAAY 198 Query: 248 VKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLR 307 + ++ D I L+ E+E + + L + L AG ETT + Sbjct: 199 FRALADARRKAPRDDLISGLLLAEEQEH-----KLSPAELSSMVFLLLVAGHETTVHLIA 253 Query: 308 YALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLP 367 +LLLL HP ++ E+ V + V E R S Sbjct: 254 SGMLLLLSHPAERRRLDEDPGLV------------------GSAVEEALRCEGPAELSTI 295 Query: 368 HAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMP 427 DI+ +P G + L + D + FP+P+ FD + Sbjct: 296 RWSLEDIELFGARVPAGEGVAAGLLAANRDPQHFPDPDRFDIGR---------SPNRHIG 346 Query: 428 FSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKN---LDTTPVVNGFASVP 480 F G C+G LA +E + +++L+ L P + G A+VP Sbjct: 347 FGGGIHFCLGAMLARIEAAIAFSTLLRRLPRIELATSTRDIVWSEWPTIRGPAAVP 402 >6A7I-A nrPDB Length = 411 Score = 182 bits (463), Expect = 2e-46, Method: Composition-based stats. Identities = 81/433 (18%), Positives = 139/433 (32%), Gaps = 86/433 (19%) Query: 62 GPVFTLYF-GLKPIVVLHGYEAVKEALID--------------LGEEFSGRGIFPLAERA 106 GP+ + G + + + + L D GE +PL A Sbjct: 26 GPLAEVELPGGVHVYAVTRHAEARALLTDSRVVKDIDVWNAWRRGEI---PMDWPLIGLA 82 Query: 107 NRGFGIVFSNGKKWKEIRRF--SLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPC 164 N G ++ +G + +R +T++ + IE L P Sbjct: 83 NPGRSMLTVDGADHRRLRTLVAQALTVKRVERLRAGIEALTNASLEKLAAL---PAGEPV 139 Query: 165 DPTFILGC-APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPII 223 D P NVI ++ D+ L E + + P Sbjct: 140 DLKAEFAYPLPMNVISELMGVDAADHP-----RLKELFEKFFSTQTPP------------ 182 Query: 224 DYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFT 283 + V M + + + ++ N D + E T Sbjct: 183 -----------EEVPQMMADLGALFTKIVDAKRTNPGDDLTSALIAASE-----NGDHLT 226 Query: 284 IESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRS 343 E + NT + AG ETT + + + L HPE KV + IG Sbjct: 227 DEEIVNTLQLIIAAGHETTISLIVNVVEALQTHPEQRKKV---LNGEIG----------- 272 Query: 344 HMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEF-P 402 D V+ E R+ L T DI+ + ++PKG ++IS ++ D +++ P Sbjct: 273 ----WDGVIEETLRWNTPTSHVLIRFATEDIEVGDKILPKGEGLIISFGALGRDEEQYGP 328 Query: 403 NPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLV 462 FD + + F G +C G AL+ +E + L ++ + F L Sbjct: 329 TAGEFD---------ATRTPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLA 379 Query: 463 DPK-NLDTTPVVN 474 P +L P+V Sbjct: 380 VPASDLRNKPIVT 392 >4RM4-A nrPDB Length = 396 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 78/406 (19%), Positives = 136/406 (33%), Gaps = 62/406 (15%) Query: 74 IVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRN 133 + + Y+ VK+ + D E FS + + G I+ + K +IR Sbjct: 47 VWSVFLYDDVKKVVGDK-ELFSSCMPQQTS---SIGNSIINMDPPKHTKIRSVVNKAFTP 102 Query: 134 FGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFHKRFDYKDQ 192 M + E R+QE L+++ + D P VI ++ Sbjct: 103 RVM--KQWEPRIQEITDELIQKFQGRSE--FDLVHDFSYPLPVIVISELLGVPSAH---- 154 Query: 193 QFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQ 252 ME+ +L S + K + ++ ++E + Sbjct: 155 -----MEQFKAWSDLLVSTPKDKSEEAEKAFL------EERDKCEEELAAFFAGIIEEKR 203 Query: 253 ESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLL 312 N P+ I L++ E+ + + E L L AG ETT+ + A+ Sbjct: 204 -----NKPEQDIISILVEAEET----GEKLSGEELIPFCTLLLVAGNETTTNLISNAMYS 254 Query: 313 LLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTC 372 +L+ P V +++ E V E R+ P L Sbjct: 255 ILETPGVYEELRSHPE------------------LMPQAVEEALRFRAPAPV-LRRIAKR 295 Query: 373 DIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGK 432 D + +LI +G +L + S D +F P MFD + F G Sbjct: 296 DTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR---------HPNPHIAFGHGI 346 Query: 433 RICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFAS 478 C+G LA +E + LTS++ F V ++ + V+ G S Sbjct: 347 HFCLGAPLARLEANIALTSLISAFPHMECVSITPIENS-VIYGLKS 391 >6B11-A nrPDB Length = 440 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 72/418 (17%), Positives = 140/418 (33%), Gaps = 74/418 (17%) Query: 71 LKPIVVLHGYEAVKEALID-LGEEFSG--RGIFPLAERANRGFGIVFSNGKKWKEIRRFS 127 P+ ++ + V+ L D + P A ++ + +R Sbjct: 86 GAPVWLISRQDHVRALLADPRVSIHPAKLPRLSPSDGEAEASRSLLTLDPPDHGALR--- 142 Query: 128 LMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFHK 185 + FG+ + R + V++ L+++L + D VIC ++ Sbjct: 143 GHFIPEFGLRRVRELRPSVEQIVTGLLDDLTA-RGDEADLLADFALPMATQVICRLL--- 198 Query: 186 RFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYIL 245 Y+D+ + + P + L+ + ++ Y+ Sbjct: 199 DIPYEDRDYFQERTEQATR----------------------PAAGEEALEALLELRDYLD 236 Query: 246 EKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTT 305 + ++ D L M + + + + AV L AG ETT++ Sbjct: 237 RLI-------SGKTGRESGDGMLGSMVAQARGGG--LSHADVLDNAVLLLAAGHETTASM 287 Query: 306 LRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTS 365 + ++L+LL+HP ++ V E+ RY+ + Sbjct: 288 VTMSVLVLLQHPTAWRELTVNPG------------------LLPGAVDELLRYLSIA-DG 328 Query: 366 LPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYF 425 L + T DI+ + I G ++ L + D F PE FD H ++ Sbjct: 329 LRRSATADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHR---------SARRH 379 Query: 426 MPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSL---VDPKNLDTTPVVNGFASVP 480 + F G C+G+ LA MEL + L ++L+ V L + V G +P Sbjct: 380 VAFGYGPHQCLGQNLARMELEVALGAVLERLPALRPTTDVAGLRLKSDSAVFGVYELP 437 >1ODO-A nrPDB Length = 408 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 75/434 (17%), Positives = 133/434 (30%), Gaps = 74/434 (17%) Query: 62 GPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVF------- 114 GP + + +K+ L R +P + + Sbjct: 28 GPATWVDVLGVQAWSVSDPVLLKQLLTSSDVSKDARAHWPAFGEVVGTWPLALWVAVENM 87 Query: 115 --SNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKT-KASPCDPTFILG 171 + G +++RR ++ V+ LV+ L + P D L Sbjct: 88 FTAYGPNHRKLRRLVAPAFS--ARRVDAMRPAVEAMVTGLVDRLAELPAGEPVDLRQELA 145 Query: 172 C-APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTH 230 P VI ++ D +D + + + Sbjct: 146 YPLPIAVIGHLM-GVPQDRRDGFRALVDGVFDTTLDQA---------------------- 182 Query: 231 NKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENT 290 + N A + + + + + + P D + L+ ++ + E L +T Sbjct: 183 -EAQANTARLYEVLDQLIAAKRAT-----PGDDMTSLLIAA-RDDEGDGDRLSPEELRDT 235 Query: 291 AVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDA 350 + + AG ETT + A+ LL P+ A V++ + + D Sbjct: 236 LLLMISAGYETTVNVIDQAVHTLLTRPDQLALVRK-----------------GEVTWAD- 277 Query: 351 VVHEVQRYIDLLPTSLPHAVTCDIKF-RNYLIPKGTTILISLTSVLHDNKEFPNPEMFDP 409 VV E R+ + DI I +G IL S + + + FD Sbjct: 278 VVEETLRHEPAVKHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHEDADTFDA 337 Query: 410 HHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDP-KNLD 468 + E + F G C+G LA ME+ L L S+ F L DP + L Sbjct: 338 TRTVKE---------HLAFGHGVHFCLGAPLARMEVTLALESLFGRFPDLRLADPAEELP 388 Query: 469 TTP--VVNGFASVP 480 P + NG +P Sbjct: 389 PVPSLISNGHQRLP 402 >4JBT-A nrPDB Length = 410 Score = 179 bits (455), Expect = 2e-45, Method: Composition-based stats. Identities = 70/420 (16%), Positives = 140/420 (33%), Gaps = 76/420 (18%) Query: 62 GPVFTLYFGLKPIVVLHGYEAVKEALIDL-----------GEEFSGRGIFPLAERANRGF 110 GP+ + P + + G+ ++ L D + + +PL + Sbjct: 30 GPLTRIDLLGVPALAVTGHTLARQLLTDTRLVKDINAWSLWQSGTVTRQWPLIGMIDVDR 89 Query: 111 GIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK--ASPCDPTF 168 + +G + + +R + L + +++ ++ L+++L + + D Sbjct: 90 SMFTVDGPEHRRLRIKTTQALTRRRL--DALKPTIERYVAELLDDLERAGADGAVVDLKS 147 Query: 169 ILGC-APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFP 227 + P VI +++ D E + + I Sbjct: 148 VFAYPLPMRVISALMGVPSED-------------QEQLLTWYKAFFSILT---------- 184 Query: 228 GTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESL 287 ++ L+ + M Y E V+ P D + L+ + + T E + Sbjct: 185 -PQDERLRVIDEMHGYFTEMVRRKTA-----EPGDDLTSALIYA----TDGETPLTEEEV 234 Query: 288 ENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPY 347 L AG ETT + + A+ LL HPE V+ + IG Sbjct: 235 IGNLQALVAAGHETTVSLILTAVRALLSHPEQLRLVR---DGEIG--------------- 276 Query: 348 TDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEF-PNPEM 406 + + E R+ + L T DI + +IP+G +++S ++ D + + Sbjct: 277 WETAIEETLRWDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGRDITVHGADADD 336 Query: 407 FDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKN 466 FD + + F G IC G ALA +E + L ++ F P + Sbjct: 337 FDITR--------ATAARHISFGHGPHICPGAALARLEAAIALPALFTRFPHLHPALPLD 388 >4Z5Q-A nrPDB Length = 423 Score = 179 bits (454), Expect = 3e-45, Method: Composition-based stats. Identities = 67/458 (14%), Positives = 139/458 (30%), Gaps = 80/458 (17%) Query: 31 PGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYF-GLKPIVVLHGYEAVKEALID 89 P P P G+ ++S+S L + G + +P ++ Y+ + L D Sbjct: 33 PAPVAYPFTGS----EGLELSQSYAKLFED-GDPIRVQLPFGEPAWLVTRYDDARFVLTD 87 Query: 90 LG--EEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQE 147 + + P I+ + +R + + + E Sbjct: 88 RRFSRHLATQRDEPRMTPRAVPESILTMDPPDHTRLRTLVSKAFTPRRIESK--RAWIGE 145 Query: 148 EARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF-----HKRFDYKDQQFLNLMEKLN 202 A LV +++ A P VIC ++ R L+ E + Sbjct: 146 LAAGLVADMKAGGAPAELVGSYALAIPVTVICELLGVPEDDRTRLRGWCDAALSTGELTD 205 Query: 203 ENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQD 262 E +++ ++ Y + VKE + P+D Sbjct: 206 EEC----------------------------VQSFMDLQKYFEDLVKERRA-----EPRD 232 Query: 263 FIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAK 322 + L+ E + L + + G ETT++ + + +L + E+ + Sbjct: 233 DLTSALI----EARDAHDRLAEPELIGLCISILIGGFETTASEISSFVHVLQQRRELWTR 288 Query: 323 VQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSL-PHAVTCDIKFRNYLI 381 + + E + A V E+ R++ + P D+ L+ Sbjct: 289 LCADPEAI------------------PAAVEELLRFVPFAANGISPRYALEDMTVGGVLV 330 Query: 382 PKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALA 441 +G +++ ++V D F N + M F G C+G LA Sbjct: 331 REGEPVIVDTSAVNRDGLVFDNADEVVIDR---------ADNRHMVFGHGAHHCLGAHLA 381 Query: 442 GMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASV 479 +EL L ++++ L ++ + Sbjct: 382 RVELQEALKALVEGMPGLRLSGDVEWKADMIIRAPRVM 419 >1CPT-A nrPDB Length = 428 Score = 177 bits (450), Expect = 7e-45, Method: Composition-based stats. Identities = 77/414 (18%), Positives = 141/414 (34%), Gaps = 52/414 (12%) Query: 67 LYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRF 126 + G +P + + + E L D E R I + + R Sbjct: 61 MQIGKQPGLFSNAEGS--EILYDQNNEAFMRSISGGCPHVIDS--LTSMDPPTHTAYRGL 116 Query: 127 SLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKR 186 +L + + R +E+ ++ A+ V+ L T P +V+ + + Sbjct: 117 TLNWFQPASI--RKLEENIRRIAQASVQRLLDFDGECDFMTDCALYYPLHVVMTALG--- 171 Query: 187 FDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILE 246 D+ LM KL ++ + P Q D + + +A Y Sbjct: 172 VPEDDE---PLMLKLTQDFFGVHEPDEQAVAAPRQSAD---EAARRFHETIATFYDYFNG 225 Query: 247 KVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTL 306 + + + P+D + L + + + V + AG +TTS++ Sbjct: 226 FTVDRR-----SCPKDDVMSLL----ANSKLDGNYIDDKYINAYYVAIATAGHDTTSSSS 276 Query: 307 RYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSL 366 A++ L ++PE A + + + +V E R+ + S Sbjct: 277 GGAIIGLSRNPEQLALAKSDPALI------------------PRLVDEAVRWTAPV-KSF 317 Query: 367 PHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFM 426 D + R I +G I++S S D + F NP+ FD F + Sbjct: 318 MRTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEFDITRF---------PNRHL 368 Query: 427 PFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 480 F G +C+G+ LA +E+ +F +L L P L T V G +VP Sbjct: 369 GFGWGAHMCLGQHLAKLEMKIFFEELLPKLKSVELSGPPRLVATNFVGGPKNVP 422 >4GGV-A nrPDB Length = 418 Score = 176 bits (447), Expect = 2e-44, Method: Composition-based stats. Identities = 69/414 (16%), Positives = 134/414 (32%), Gaps = 63/414 (15%) Query: 74 IVVLHGYEAVKEALIDLG---EEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMT 130 + ++GY + L D + + + G + + + ++ R+ Sbjct: 55 VWNVYGYPEAMDILNDHDTFTSDLAHLLPVSVDAPLLEG-DMSQMDPPRHRKYRQLVSRA 113 Query: 131 LRNFGMGKRSIEDRVQEEARCLVEE--LRKTKASPCDPTFILGCAPCNVICSIIFHKRFD 188 + +E RV + R L++ + D + L P VI ++ Sbjct: 114 FTPRLVAD--METRVADITRELLDAVDGKPEIEIAADLAYPL---PVIVIAELLG---VP 165 Query: 189 YKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDY-FPGTHNKLLKNVAFMKSYILEK 247 D+ + I FS G + +++ +L+ Sbjct: 166 AGDR-------------DLFKKWADDIIEGFSGFSFLDTSGQGEQDVRDATERLRPLLDY 212 Query: 248 VKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLR 307 + H +D + + T + N A L G TT+ TL Sbjct: 213 MAGHVTERRRTPREDLLTHLVQAEV-----DGERLTDNEIVNVANILLVTGHITTTMTLG 267 Query: 308 YALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLP 367 +L L PEV AKV+ + V G + E R + +L Sbjct: 268 NTVLCLDADPEVAAKVRADRSLVPG------------------AIEEALRVLSP-SAALA 308 Query: 368 HAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMP 427 + +++ +IPK +++ L + D ++F +PE++DP Sbjct: 309 RGTSREVEVAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVYDPTR---------DPNPHFG 359 Query: 428 FSAGKRICVGEALAGMELFLFLTSILQNFNLKS--LVDPKNLDTTPVVNGFASV 479 F G C+G LA +E + L ++ F + P TP + G ++ Sbjct: 360 FGRGIHFCLGAPLARLEGRVALNALFDRFPVLRTDPAKPPTFFPTPDMIGVNTL 413 >1UED-A nrPDB Length = 406 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 77/429 (17%), Positives = 140/429 (32%), Gaps = 76/429 (17%) Query: 62 GPVFTL------YFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFS 115 GP+ + G + HGYE V+ L D E F+ R F ++ Sbjct: 37 GPLVRIVGESSTQLGRDFVWQAHGYEVVRRILGDH-EHFTTRPQFTQSKSGAHVEAQFVG 95 Query: 116 NGKKW--KEIRRFSLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPCDPTFILGC 172 + E R M F + + R +E +Q ++ L D + Sbjct: 96 QISTYDPPEHTRLRKMLTPEFTVRRIRRMEPAIQSLIDDRLDLLEAE-GPSADLQGLFAD 154 Query: 173 AP-CNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHN 231 + +C ++ R D ++F+ + + D G Sbjct: 155 PVGAHALCELLGIPRDD--QREFVRRIRRN---------------------ADLSRGLKA 191 Query: 232 KLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTA 291 + + AF + +++ D D L + ++ + T E L+ Sbjct: 192 RAADSAAFNRYL---------DNLLARQRADPDDGLLGMIVRDHGDN---VTDEELKGLC 239 Query: 292 VDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAV 351 L G ET + + + +L LL +P + E E+ + V Sbjct: 240 TALILGGVETVAGMIGFGVLALLDNPGQIELLFESPEK------------------AERV 281 Query: 352 VHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHH 411 V+E+ RY+ + P D+ LI G +L S+ D P+P++ D Sbjct: 282 VNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDPDVLD--- 338 Query: 412 FLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTP 471 + + + F G CVG ALA L + ++ + F L P ++ Sbjct: 339 ------ANRAAVSDVGFGHGIHYCVGAALARSMLRMAYQTLWRRFPGLRLAVP--IEEVK 390 Query: 472 VVNGFASVP 480 + F P Sbjct: 391 YRSAFVDCP 399 >6M7L-A nrPDB Length = 404 Score = 176 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 79/416 (18%), Positives = 141/416 (33%), Gaps = 80/416 (19%) Query: 62 GPVFTLYF--GLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGF--GIVFSNG 117 GP+ + G GY+ V+E L E+F R I ++ + Sbjct: 48 GPLVRIPLEDGSAVHWFALGYDVVREVLGS--EKFDKRVIGTHFNHQEMALPGNLLQLDP 105 Query: 118 KKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNV 177 + +RR M +++E RVQ ++ + T + G V Sbjct: 106 PEHTRLRRMVAPAYSVRRM--QALEPRVQAIVDDHLDTMASTGPPVEFLREVAGPMAARV 163 Query: 178 ICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNV 237 C + D+ E I++ + G ++L Sbjct: 164 ACEFLG---IPLDDR---------GELIRLTAHRG---------------GKRRRVLNGH 196 Query: 238 AFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGA 297 A++ +Y+ E + +D D L + ++ ++ + E L + + Sbjct: 197 AYL-AYMRELAARLR--------RDPGDGMLGMVARDH---GADISDEELAGLCAVVMNS 244 Query: 298 GTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQR 357 E T + L LLLL+HPE A ++E E + V E+ R Sbjct: 245 SVEQTESCLAAGTLLLLEHPEQFALLRERPE------------------LGEQAVEEIVR 286 Query: 358 YIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLH-DNKEFPNPEMFDPHHFLDEG 416 Y+ + P T D++ +I KG + SL + D + FD Sbjct: 287 YLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAANRADPAL----DGFDITR----- 337 Query: 417 GNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFN-LKSLVDPKNLDTTP 471 K + F G C+G LA MEL + T+++ F L++ V + + P Sbjct: 338 ----KESRHVAFGHGIHHCLGAPLARMELRIAFTTLVSRFPSLRTAVPAEEIRFRP 389 >5NWS-A nrPDB Length = 435 Score = 176 bits (445), Expect = 3e-44, Method: Composition-based stats. Identities = 64/431 (14%), Positives = 132/431 (30%), Gaps = 81/431 (18%) Query: 56 NLSKVYGPVFTLYFG-LKPIVVLHGYEAVKEALIDLGEEFSGRGI--------------- 99 L + GPV F P+ + Y+ V+ L D + + Sbjct: 42 RLRER-GPVVRGRFVDGTPVWFVTRYDDVRAVLRDPRFVNTPSPVPGEGGADPREGMMDL 100 Query: 100 --FPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEEL- 156 P R I+ S+ +RR + + ++ A L+ EL Sbjct: 101 LNVPEPLRVYLLGSILDSDPPDHPRLRRLVTRAFAARRIL--GLRPGIERIADRLLAELP 158 Query: 157 -RKTKASPCDPTFILGC-APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQ 214 R+ + D VIC ++ W + Sbjct: 159 RREEEDGTVDLLEHFAYPLSITVICELV--------------------GIPATDLERWRE 198 Query: 215 ICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKE 274 + + +L + M Y +++ + + D L ++ + Sbjct: 199 WGGDLVSMRP------ERLRHSFPVMIDYCHRLIEQRRAA--------LTDDLLSELIRA 244 Query: 275 KHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRN 334 + + + + L AG ET++ + LL HP A ++++ Sbjct: 245 QDDDGGRLSDIETVTMILTLVLAGHETSAHLIGNGTAALLTHPGQWALLRKDPA------ 298 Query: 335 RSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSV 394 VHE+ R+ + + T D++ + +G + + L S Sbjct: 299 ------------LLPRAVHELMRWCGSVHVARLRYATEDLELAGTPVARGDAVQLVLVSA 346 Query: 395 LHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQ 454 D + + +P+ D + +++ + F G C+G LA E + L +L+ Sbjct: 347 NFDPRHYSDPDRLDITRHQE-----GQAENHVGFGHGIHYCLGATLARQEGEVALARLLE 401 Query: 455 NFNLKSLVDPK 465 + +L D Sbjct: 402 TYPDLALADGD 412 >3P3Z-A nrPDB Length = 416 Score = 175 bits (444), Expect = 3e-44, Method: Composition-based stats. Identities = 65/377 (17%), Positives = 121/377 (32%), Gaps = 59/377 (15%) Query: 106 ANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKTKASPC 164 R F + F + RR + F + +++ V+ L+++L Sbjct: 91 PVRDFMVDFLQSLDGADHRRLRGLATHPFTPRRITAVQPFVRSTVEQLIDKL---PQGDF 147 Query: 165 DPTFIL-GCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPII 223 D P V+C ++ DY L++ N+ + S I Sbjct: 148 DFVQHFPHPLPALVMCQLLGFPLEDYDTVGRLSI----ETNLGLALSNDQDIL------- 196 Query: 224 DYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFT 283 K+ + + M Y++ +++ + + D + F + Sbjct: 197 -------VKVEQGLGRMFDYLVAAIEKRKVEPGDDLTSDIVRAFHDGV----------LD 239 Query: 284 IESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRS 343 L + AG ETT+ L A+ +HP+ K++E E Sbjct: 240 DYELRTLVATVLVAGYETTNHQLALAMYDFAQHPDQWMKIKENPE--------------- 284 Query: 344 HMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPN 403 V EV R+ LP + D + IP GT + + D + F + Sbjct: 285 ---LAPQAVEEVLRWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVFAD 341 Query: 404 PEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVD 463 + FD K+ + F G C+G ALA +EL + ++ + + Sbjct: 342 ADRFDI--------TVKREAPSIAFGGGPHFCLGTALARLELTEAVAALATRLDPPQIAG 393 Query: 464 PKNLDTTPVVNGFASVP 480 V G ++P Sbjct: 394 EITWRHELGVAGPDALP 410 >1GWI-A nrPDB Length = 411 Score = 174 bits (442), Expect = 6e-44, Method: Composition-based stats. Identities = 80/431 (18%), Positives = 139/431 (32%), Gaps = 83/431 (19%) Query: 62 GPVFTLYF-GLKPIVVLHGYEAVKEALID--------------LGEEFSGRGIFPLAERA 106 GP+ + G P+ + + K L D GE +PL A Sbjct: 30 GPLAAVELPGGVPVWAVTHHAEAKALLTDPRLVKDINVWGAWRRGEI---PADWPLIGLA 86 Query: 107 NRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDP 166 N G ++ +G + + +R L + R+ E L++EL D Sbjct: 87 NPGRSMLTVDGAEHRRLRTLVAQALT--VRRVEHMRGRITELTDRLLDELPAD-GGVVDL 143 Query: 167 TFILGC-APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDY 225 P V+ ++ ++ L ++ L E +P ++ + Sbjct: 144 KAAFAYPLPMYVVADLMG------IEEARLPRLKVLFEKFFSTQTPPEEVVATLT----- 192 Query: 226 FPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIE 285 + S + + V + + P D + L+ + T Sbjct: 193 -------------ELASIMTDTVAAKRAA-----PGDDLTSALI----QASENGDHLTDA 230 Query: 286 SLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHM 345 + +T + AG ETT + + A++ L HPE A V S Sbjct: 231 EIVSTLQLMVAAGHETTISLIVNAVVNLSTHPEQRALV------------------LSGE 272 Query: 346 PYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEF-PNP 404 AVV E R+ L D+ + +IP G +++S ++ D + P Sbjct: 273 AEWSAVVEETLRFSTPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTA 332 Query: 405 EMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDP 464 + FD + F G +C G AL+ ME + L ++ F L P Sbjct: 333 DRFDLTR--------TSGNRHISFGHGPHVCPGAALSRMEAGVALPALYARFPHLDLAVP 384 Query: 465 -KNLDTTPVVN 474 L PVV Sbjct: 385 AAELRNKPVVT 395 >3S79-A nrPDB Length = 503 Score = 174 bits (441), Expect = 9e-44, Method: Composition-based stats. Identities = 89/441 (20%), Positives = 174/441 (39%), Gaps = 33/441 (7%) Query: 31 PGPTPLPVIGNILQIGI---KDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEAL 87 PGP IG ++ G I + ++VYG ++ + +++ ++ Sbjct: 48 PGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSM--FH 105 Query: 88 IDLGEEFSGRGIFPLAERANRGF--GIVFSNGKK-WKEIRRFSLMTLRNFGMGKRSIEDR 144 I +S R L + GI+F+N + WK R F + L G G + Sbjct: 106 IMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALS--GPGLVRMVTV 163 Query: 145 VQEEARCLVEELRKTKASP--CDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLN 202 E + ++ L + D +L + +F R + ++ K+ Sbjct: 164 CAESLKTHLDRLEEVTNESGYVDVLTLL-RRVMLDTSNTLF-LRIPLDESA---IVVKIQ 218 Query: 203 ENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVA-FMKSYILEKVKEHQESMDMNNPQ 261 + I+ F I + + K +K++ ++ I EK + + Sbjct: 219 GYFDAWQALLIKPDIFFK--ISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECM 276 Query: 262 DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTA 321 DF ++ ++ + T E++ +++ A +T S +L + L L+ KHP V Sbjct: 277 DFATELILAEKR------GDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEE 330 Query: 322 KVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLI 381 + +EI+ VIG R + D + + ++E RY ++ + D Y + Sbjct: 331 AIIKEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYPV 388 Query: 382 PKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALA 441 KGT I++++ + FP P F +F +YF PF G R C G+ +A Sbjct: 389 KKGTNIILNIGRMHRLE-FFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIA 443 Query: 442 GMELFLFLTSILQNFNLKSLV 462 + + L ++L+ F++K+L Sbjct: 444 MVMMKAILVTLLRRFHVKTLQ 464 >5OFQ-A nrPDB Length = 409 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 80/420 (19%), Positives = 143/420 (34%), Gaps = 70/420 (16%) Query: 71 LKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMT 130 + + YE VK L FS + R I+ + K ++R Sbjct: 48 SRNCWDVFDYETVKYIL-KNPSLFSSKRAME-----ERQESILMMDPPKHTKLRNLVNKA 101 Query: 131 LRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFIL-GCAPCNVICSIIFHKRFDY 189 + +E ++E A L++E + D G P VI ++ Sbjct: 102 FTP--RAIQHLEGHIEEIADYLLDE--VSSKEKFDIVEDFAGPLPIIVIAELLG---VPI 154 Query: 190 KDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVK 249 +D+ ++S F+ ++ K + V F++ Y E + Sbjct: 155 QDRALFKKYSD-----DLVSGAENNSDEAFAKMM-------QKRNEGVIFLQGYFKEIIA 202 Query: 250 EHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYA 309 E Q+ N +D I L E T E + + L AG ETT+ + Sbjct: 203 ERQQ----NKQEDLISLLL-----EAEIDGEHLTEEEVLGFCILLLVAGNETTTNLITNG 253 Query: 310 LLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHA 369 + + + +V +V+ +I V +V E RY + ++ Sbjct: 254 VRYMTEDVDVQNEVRRDISLV------------------PNLVEETLRYYPPIQ-AIGRI 294 Query: 370 VTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFS 429 D++ I +G ++ S D+ +F P+ F H K+ + F Sbjct: 295 AAEDVELGECKIKRGQQVISWAASANRDSAKFEWPDTFVVHR---------KTNPHVSFG 345 Query: 430 AGKRICVGEALAGMELFLFLTSILQN--FNLKSLVDPKNLDTTPVVNGFASVPPFYQLCF 487 G C+G LA ME + T +L+ F+ K +D+ P V G Y++ F Sbjct: 346 FGIHFCLGAPLARMEGKIAFTKLLEKGGFSKVQNQSLKPIDS-PFVFGVKK----YEIAF 400 >4XE3-A nrPDB Length = 407 Score = 171 bits (434), Expect = 5e-43, Method: Composition-based stats. Identities = 69/461 (14%), Positives = 132/461 (28%), Gaps = 85/461 (18%) Query: 30 PPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYF--GLKPIVVLHGYEAVKEAL 87 P P LP + L + L + PV + G ++ + L Sbjct: 15 PAYPFSLP---HALDLD-----PHYAELRRDE-PVSRVRLPYGEGTAWLVTRMSDARIVL 65 Query: 88 IDLGEEFS-----GRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIE 142 D FS + G++ + +RR + Sbjct: 66 GD--SRFSTAAATDPATPRMFPTPPEPDGVLAQDPPDHTRLRRLVGKAFT--ARRVEEMR 121 Query: 143 DRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFHKRFDYKDQQFLNLMEKL 201 RV+ L++++ SP D L P VIC ++ Sbjct: 122 PRVRSLVDSLLDDMVAH-GSPADLVEFLAVPFPVAVICELLG------------------ 162 Query: 202 NENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQ 261 ++ + F D + + ++ + + + Sbjct: 163 ---------VPLEDRDLFRTFSDAMLSSTRLTAAEIQRVQQDFMVYMDGLVAQRRDAPTE 213 Query: 262 DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTA 321 D + + + + H T + N V L AG ET+ + + LLL + Sbjct: 214 DLLGALALATDNDDH-----LTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLTERKRYE 268 Query: 322 KVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLP-HAVTCDIKFRNYL 380 + + V A V E+ RY L+ T D++ Sbjct: 269 SLVADPALV------------------PAAVEEMLRYTPLVSAGSFVRVATEDVELSTVT 310 Query: 381 IPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEAL 440 + G ++ S D + F + + D H + + F G C+G L Sbjct: 311 VRAGEPCVVHFASANRDEEVFDHADELDFHR---------ERNPHIAFGHGAHHCIGAQL 361 Query: 441 AGMELFLFLTSILQNFNLKSLVDP---KNLDTTPVVNGFAS 478 +EL L+++++ F L +P ++ G Sbjct: 362 GRLELQEALSALVRRFPTLDLAEPVAGLKWKQGMLIRGLER 402 >3MGX-A nrPDB Length = 415 Score = 171 bits (432), Expect = 9e-43, Method: Composition-based stats. Identities = 71/375 (18%), Positives = 128/375 (34%), Gaps = 67/375 (17%) Query: 107 NRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDP 166 + G +V S ++ +++R+ L R + +RV+ E ++ R CD Sbjct: 101 SGGRMMVVSEHEQHRKLRKLVGPLLSR--AAARKLAERVRIEVGDVL--GRVLDGEVCDA 156 Query: 167 TFILG-CAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDY 225 +G P V+C I+ +D+ L I + + + F + Sbjct: 157 ATAIGPRIPAAVVCEILG---VPAEDEDML---------IDLTNHAFGGEDELFDGMTP- 203 Query: 226 FPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIE 285 + + Y E + ++ P D + L+ + TI+ Sbjct: 204 --------RQAHTEILVYFDELITARRK-----EPGDDLVSTLVT--------DDDLTID 242 Query: 286 SLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHM 345 + ++ G ETT + A+ L P + +++ V Sbjct: 243 DVLLNCDNVLIGGNETTRHAITGAVHALATVPGLLTALRDGSADV--------------- 287 Query: 346 PYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPE 405 D VV EV R+ L T D+ +P GT ++ L + D EF +P+ Sbjct: 288 ---DTVVEEVLRWTSPAMHVL-RVTTADVTINGRDLPSGTPVVAWLPAANRDPAEFDDPD 343 Query: 406 MFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPK 465 F P K + F G C+G ALA +EL + L + + + L Sbjct: 344 TFLPGR---------KPNRHITFGHGMHHCLGSALARIELSVVLRVLAERVSRVDLEREP 394 Query: 466 NLDTTPVVNGFASVP 480 VV G+ +P Sbjct: 395 AWLRAIVVQGYRELP 409 >5GWE-A nrPDB Length = 405 Score = 169 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 68/436 (15%), Positives = 136/436 (31%), Gaps = 72/436 (16%) Query: 45 IGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSG-------- 96 + + + L + +F G V+ Y+ +K D E FS Sbjct: 9 FDMHNPFPAYKELRQEEPVMFDERIG---YWVVTKYDDIKTTF-DDWETFSSENAQAPVR 64 Query: 97 -RGIFPLAERANRGF----GIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARC 151 RG + GF G+ + IR + +++E ++ Sbjct: 65 KRGPQATQIMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTPRRY--KALEPDIRAMVID 122 Query: 152 LVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSP 211 VE++ D L D + ++ + +I ++ + Sbjct: 123 RVEKMLANDQHVGDMVSDLAY------------------DIPTITILTLIGADISMVDT- 163 Query: 212 WIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKM 271 + + ++ + + ++ ++ + + + M + D + Sbjct: 164 YKRWSDSRAAMTWGDLSDEEQIPHAHNLVEYW------QECQRMVADAHAHGGDNLTADL 217 Query: 272 EKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVI 331 + + E T + + L AG ETT+T + +LL HPE + E + + Sbjct: 218 VRAQQE-GQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILENPKLI- 275 Query: 332 GRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISL 391 A V EV RY + D + I +G +L+ + Sbjct: 276 -----------------PAAVDEVLRYSGSI-VGWRRKALKDTEIGGVAIKEGDGVLLLM 317 Query: 392 TSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTS 451 S D F N E FD ++ + F G C+G LA ++ + L Sbjct: 318 GSANRDEARFENGEEFDISR--------ANAREHLSFGFGIHYCLGNMLAKLQAKICLEE 369 Query: 452 ILQNFNLKSLVDPKNL 467 + + LV K + Sbjct: 370 VTRLVPSLHLVADKAI 385 >5XJN-A nrPDB Length = 455 Score = 169 bits (427), Expect = 4e-42, Method: Composition-based stats. Identities = 68/436 (15%), Positives = 136/436 (31%), Gaps = 72/436 (16%) Query: 45 IGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSG-------- 96 + + + L + +F G V+ Y+ +K D E FS Sbjct: 59 FDMHNPFPAYKELRQEEPVMFDERIG---YWVVTKYDDIKTTF-DDWETFSSENAQAPVR 114 Query: 97 -RGIFPLAERANRGF----GIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARC 151 RG + GF G+ + IR + +++E ++ Sbjct: 115 KRGPQATQIMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTPRRY--KALEPDIRAMVID 172 Query: 152 LVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSP 211 VE++ D L D + ++ + +I ++ + Sbjct: 173 RVEKMLANDQHVGDMVSDLAY------------------DIPTITILTLIGADISMVDT- 213 Query: 212 WIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKM 271 + + ++ + + ++ ++ + + + M + D + Sbjct: 214 YKRWSDSRAAMTWGDLSDEEQIPHAHNLVEYW------QECQRMVADAHAHGGDNLTADL 267 Query: 272 EKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVI 331 + + E T + + L AG ETT+T + +LL HPE + E + + Sbjct: 268 VRAQQE-GQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAILENPKLI- 325 Query: 332 GRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISL 391 A V EV RY + D + I +G +L+ + Sbjct: 326 -----------------PAAVDEVLRYSGSI-VGWRRKALKDTEIGGVAIKEGDGVLLLM 367 Query: 392 TSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTS 451 S D F N E FD ++ + F G C+G LA ++ + L Sbjct: 368 GSANRDEARFENGEEFDISR--------ANAREHLSFGFGIHYCLGNMLAKLQAKICLEE 419 Query: 452 ILQNFNLKSLVDPKNL 467 + + LV K + Sbjct: 420 VTRLVPSLHLVADKAI 435 >5HH3-A nrPDB Length = 397 Score = 168 bits (426), Expect = 4e-42, Method: Composition-based stats. Identities = 72/411 (17%), Positives = 129/411 (31%), Gaps = 75/411 (18%) Query: 62 GPVFTLYF----GLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFG-IVFSN 116 GP+ TL G + + GY+ +++ L ++FS R ++ G + + Sbjct: 38 GPLTTLGTEESPGGRTAWLATGYDEIRQVLSS--DDFSARLLYGGTAAGITWPGFLTQYD 95 Query: 117 GKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCN 176 + +RR M + + +V+ + ++ + P D G + Sbjct: 96 PPEHTRLRRMVAPAFAVRRM--QKFQPQVERVVQDSLDAIEAL-GGPVDFVPRFGWSVAT 152 Query: 177 VICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKN 236 DQ D H + Sbjct: 153 TATCDFLG--IPRDDQA------------------------------DLARSLHASRTER 180 Query: 237 VAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFG 296 ++ K + M +D D + +E E T L A + G Sbjct: 181 SGKRRTAAGNKFMTYMNKMTARTRRDPGDDMFGVVVRE---YGDEITDAELTGVAAFVMG 237 Query: 297 AGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQ 356 AG + + L L+ PE A ++E+ + V P D EV Sbjct: 238 AGADQVARFLAAGAWLMADDPEQFALLREKPDTV------PDWLD------------EVI 279 Query: 357 RYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNP-EMFDPHHFLDE 415 RY+ + P T D++ ++LI G T+ SL + + FP P + FD E Sbjct: 280 RYLTTDEKTHPRVATDDVRIGDHLIKAGDTVTCSLLAANR--RNFPRPEDRFDITRVRPE 337 Query: 416 GGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKN 466 + F G C+G +LA + + ++ F L +P Sbjct: 338 ---------HLAFGHGIHHCLGRSLAELVFRTAIPALAHRFPTLRLAEPHR 379 >5LIE-A nrPDB Length = 414 Score = 168 bits (426), Expect = 4e-42, Method: Composition-based stats. Identities = 63/377 (16%), Positives = 120/377 (31%), Gaps = 57/377 (15%) Query: 104 ERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASP 163 + G + + + IRR L R +ED ++ AR L++ +P Sbjct: 87 DLPVAGQVLNMMDDPRHTRIRRLVSSGLTP--RMIRRVEDDLRRRARGLLDG--VEPGAP 142 Query: 164 CDPTFILGC-APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPI 222 D + P +IC ++ D+ +L E + S + Sbjct: 143 FDFVVEIAAELPMQMICILLG---VPETDRHWLF--EAVEPGFDFRGSRRATM------- 190 Query: 223 IDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEF 282 + + + +Y LE + + P D + + + + P+ Sbjct: 191 ------PRLNVEDAGSRLYTYALELI-----AGKRAEPADDMLSVVANATIDDPDAPA-L 238 Query: 283 TIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDR 342 + L LF AG ETT ++ LL L ++P+ ++ + E Sbjct: 239 SDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSDFE-------------- 284 Query: 343 SHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFP 402 + E+ R+ P+ + + I G +++ S D F Sbjct: 285 ----LLPTAIEEIVRWTSPSPSK-RRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFD 339 Query: 403 NPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLV 462 + FD K + F G C+G LA +EL + +L F +V Sbjct: 340 RADEFDITR---------KPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFGSVRVV 390 Query: 463 DPKNLDTTPVVNGFASV 479 +P + G + Sbjct: 391 EPAEWTRSNRHTGIRHL 407 >1EHE-A nrPDB Length = 403 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 64/419 (15%), Positives = 124/419 (29%), Gaps = 69/419 (16%) Query: 71 LKPIVVLHGYEAVKEALIDLG-EEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLM 129 K + + E + + G E S G + V + + R Sbjct: 48 HKDVCFVATSEKLSKVRTRQGFPELSASGKQAAKAKPTF----VDMDPPEHMHQRSMVEP 103 Query: 130 TLRNFGMGKRSIEDRVQEEARCLVEELRKTK--ASPCDPTFILGCAPCNVICSIIFHKRF 187 T ++++ +Q L+E++++ P D + I + Sbjct: 104 TFTP--EAVKNLQPYIQRTVDDLLEQMKQKGCANGPVDLVKEFALPVPSYIIYTLLG--V 159 Query: 188 DYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEK 247 + D ++L + N T + + Y+ Sbjct: 160 PFNDLEYLTQQNAIRTNGS---------------------STAREASAANQELLDYLAIL 198 Query: 248 VKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLR 307 V++ P+D I L + +P A L AG T + Sbjct: 199 VEQRLV-----EPKDDIISKLCTEQV----KPGNIDKSDAVQIAFLLLVAGNATMVNMIA 249 Query: 308 YALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLP 367 + L +HP+ A+++ V E+ RY ++ Sbjct: 250 LGVATLAQHPDQLAQLKANPS------------------LAPQFVEELCRYHTASALAIK 291 Query: 368 HAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMP 427 D+ + L+ I+ S S D + F NP+ F+ + + Sbjct: 292 RTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNRKWPPQDP-------LG 344 Query: 428 FSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDP-KNLDTTPVVN--GFASVPPFY 483 F G C+ E LA EL +++ Q F + P ++ TP+ G +P + Sbjct: 345 FGFGDHRCIAEHLAKAELTTVFSTLYQKFPDLKVAVPLGKINYTPLNRDVGIVDLPVIF 403 >6F0B-A nrPDB Length = 395 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 74/405 (18%), Positives = 130/405 (32%), Gaps = 66/405 (16%) Query: 63 PVFTLYF-GLKPIVVLHGYEAVKEALIDLG-EEFSGRGIFPLAERANRGFGIV--FSNGK 118 PV + P V GYE V+ L D S R F + F Sbjct: 28 PVAKVGLWNGTPAHVFSGYEDVRTVLQDRRFSSDSRRPNFTELTPTLQSQAAAPPFVRTD 87 Query: 119 KWKEIRRFSLMTLRNF-GMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNV 177 + RR R F + ++E + +++ L +T A P D + Sbjct: 88 N-PDHRRLRGTIAREFLPKHIELLRPAIREIVQGVLDGLAET-APPQDMLEAFAVPVASA 145 Query: 178 ICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNV 237 + +D+ L + + + S ++ + Sbjct: 146 TVFRLLG--IPAEDRALLT--RCVKGVVSAVGS-------------------EDEGAEVF 182 Query: 238 AFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGA 297 + YI V++ P + + L++ Q + T + L Sbjct: 183 RTLGEYIGGLVQD---------PSELPEDSLIRRLVTGPYQEKQLTFHETIGVILMLIVG 233 Query: 298 GTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQR 357 G +TT++T+ +L+ PE + V E ER+ P V E+ R Sbjct: 234 GYDTTASTISLSLVSYALQPEKFSVVHEHPERI---------------PLL---VEELLR 275 Query: 358 YIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGG 417 Y + L T D++ + G ++ +L D FPNP+ D Sbjct: 276 YHTVSQLGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDR------ 329 Query: 418 NFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLV 462 S + F G CVG+ALA +EL + ++++ L Sbjct: 330 ---PSVPHVGFGYGPHQCVGQALARVELQEAIPAVIRRLPGMRLA 371 >5XW2-A nrPDB Length = 419 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 67/412 (16%), Positives = 134/412 (32%), Gaps = 57/412 (13%) Query: 74 IVVLHGYEAVKEALIDLG--EEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTL 131 ++GY E L D G R + A+ A ++ ++ +E+R+ Sbjct: 54 AWNVYGYAEAIEVLGDPGTFSSHMSRLLPMGADEAFTEGDLLQTDPPDHRELRKLVSHAF 113 Query: 132 RNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFHKRFDYK 190 + +E R+ + L++ + D L P V+ ++ Sbjct: 114 TPKVVA--ELEPRITALTQELLDAVADR--DTFDLMTALAYPLPVTVVAELL---SIPSA 166 Query: 191 DQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKE 250 D+ + + + ++ P ++ + +LE ++E Sbjct: 167 DRHL------FEGWMTEIVHSLGDVS------MEDAPEDQERIFEAGMAPMRKMLEYLRE 214 Query: 251 HQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYAL 310 H D + + E T + N A L AG TT+ + + Sbjct: 215 HAAECRRRPRGDLMGKLI-----EAEVDGRRLTDNHIVNFAKMLLIAGYLTTTMLIGNTV 269 Query: 311 LLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAV 370 L L +PE A+V+ + + G + E R++ + + A Sbjct: 270 LCLDSYPEQAARVRADRSLIPGL------------------LEESMRFLSPV-AATYRAT 310 Query: 371 TCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSA 430 T D++ + +++ + D ++F PE+FD + + F Sbjct: 311 TRDVEVAGQRLSADQMVMVWFGAANRDARQFAEPELFD---------MTRGPNPHLGFGR 361 Query: 431 GKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPV--VNGFASVP 480 G C+G LA ME + L +L F + P G +S+P Sbjct: 362 GIHFCLGGPLARMEGRVALDHLLDRFPELYTDPERPPTFMPGFDTTGVSSLP 413 >5DE9-A nrPDB Length = 410 Score = 164 bits (415), Expect = 8e-41, Method: Composition-based stats. Identities = 84/476 (17%), Positives = 154/476 (32%), Gaps = 89/476 (18%) Query: 19 LWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYF--GLKPIVV 76 + ++ + P P + + D LT L GPV + G + Sbjct: 1 MTEETISQAVPPVRDWP------AVDLPGSDFDPVLTELM-REGPVTRISLPNGEGWAWL 53 Query: 77 LHGYEAVKEALIDLG---EEFSGRGIFPLAERANRGFG-IVFSNGKKWKEIRRFSLMTLR 132 + ++ V+ D E R + LA G + F + +RR Sbjct: 54 VTRHDDVRLVTNDPRFGREAVMDRQVTRLAPHFRPARGAVGFLDPPDHTRLRRSVAAAFT 113 Query: 133 NFGMGKRSIEDRVQEEARCLVEELRKTK---ASPCDPTF-ILGCAPCNVICSIIFHKRFD 188 G+ +RV+E +R +++EL P D T +L P VIC ++ Sbjct: 114 ARGV------ERVRERSRGMLDELVDAMLRAGPPADLTEAVLSPFPIAVICELMG---VP 164 Query: 189 YKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKV 248 D+ + W Q+ + S + + M +Y + + Sbjct: 165 ATDRHSM--------------HTWTQLILSSSHGAEVSE-------RAKNEMNAYFSDLI 203 Query: 249 KEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRY 308 + ++ + + L E T+ AV L G E + Sbjct: 204 -----GLRSDSAGEDVTSLLGAAVGR-----DEITLSEAVGLAVLLQIGG-EAVTNNSGQ 252 Query: 309 ALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLL-PTSLP 367 LLL PE+ +++ E E + E+ R+I L Sbjct: 253 MFHLLLSRPELAERLRSEPE------------------IRPRAIDELLRWIPHRNAVGLS 294 Query: 368 HAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMP 427 D++ + I G + +S + D + FP+P+ D + Sbjct: 295 RIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFER---------SPNPHVS 345 Query: 428 FSAGKRICVGEALAGMELFLFLTSILQNFN-LKSLVDPKNLDTTP--VVNGFASVP 480 F G C G LA +E L + ++L LK V P+++ ++ G ++P Sbjct: 346 FGFGPHYCPGGMLARLESELLVDAVLDRVPGLKLAVAPEDVPFKKGALIRGPEALP 401 >3NC3-A nrPDB Length = 441 Score = 164 bits (414), Expect = 1e-40, Method: Composition-based stats. Identities = 77/418 (18%), Positives = 137/418 (32%), Gaps = 57/418 (13%) Query: 47 IKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERA 106 + + L + PV Y + Y V+ L + F+ + + AE Sbjct: 52 QNNPYAYFSQLRE-EDPVH--YEESIDSYFISRYHDVRYIL-QHPDIFTTKSLVERAEPV 107 Query: 107 NRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEE-LRKTKASPC- 164 RG + +GK+ RR + + G + +++ A L+ L + K+ Sbjct: 108 MRGPVLAQMHGKEHSAKRRIVVRSF--IGDALDHLSPLIKQNAENLLAPYLERGKSDLVN 165 Query: 165 DPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIID 224 D L L ++ +E I S W +F I Sbjct: 166 DFGKTFAVCVTM----------------DMLGLDKRDHEKI----SEWHSGVADFITSIS 205 Query: 225 YFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTI 284 P L + Y++ +KE + +N D I + + Sbjct: 206 QSPEARAHSLWCSEQLSQYLMPVIKERR----VNPGSDLISILCTSEYE-----GMALSD 256 Query: 285 ESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSH 344 + + +++ A TE TL + LL +PE V + DRS Sbjct: 257 KDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDV---------------LADRSL 301 Query: 345 MPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNP 404 +P + E RY + +P ++ D I K T + + + D + F P Sbjct: 302 VP---RAIAETLRYKPPVQL-IPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQP 357 Query: 405 EMFDPHHF-LDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSL 461 ++F+ H L F + + F +G CVG A A E+ + +L L Sbjct: 358 DVFNIHREDLGIKSAFSGAARHLAFGSGIHNCVGTAFAKNEIEIVANIVLDKMRNIRL 415 >5XNT-A nrPDB Length = 411 Score = 163 bits (412), Expect = 2e-40, Method: Composition-based stats. Identities = 77/407 (18%), Positives = 135/407 (33%), Gaps = 67/407 (16%) Query: 71 LKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFG-------IVFSNGKKWKEI 123 + YE VK L D S R ++ + G I ++ + ++ Sbjct: 40 GTDTWNVFKYEDVKRVLSDYKHFSSVRKRTTISVGTDSEEGSVPDKIKITEADPPEHRKR 99 Query: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF 183 R + ++ E R+QE A L+EE+ + + P V+ ++ Sbjct: 100 RSLLAAAFTPRSL--QNWEPRIQEIADELIEEMDEETEIDI-VQSLASPLPIIVMSDLMG 156 Query: 184 HKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLK-NVAFMKS 242 D ++L W+ I F P N+L + Sbjct: 157 VPSKD-----------------RLLFKKWVDI--LFLPFDKEKQEEVNELKQVAAKEYYQ 197 Query: 243 YILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETT 302 Y+ V + + +N D I L FT + + T + + GAG ETT Sbjct: 198 YLYPIVVQKR----LNPADDIISDLLKAEV-----DGEMFTDDEVVRTTMLILGAGVETT 248 Query: 303 STTLRYALLLLL-KHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDL 361 S L + LL EV ++ E ++ V V E+ RY Sbjct: 249 SHLLANSFYSLLYDDKEVYQELHENLDLV------------------PQAVEEMLRYR-F 289 Query: 362 LPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKK 421 L V D + +G +++ +++ D + F + + H Sbjct: 290 NLIKLDRTVKEDNDLLGVELKEGENVVVWMSAANLDEEMFEDAFTLNIHR--------PN 341 Query: 422 SKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLD 468 +K + F G C+G LA +E + LT+ L+ F V L+ Sbjct: 342 NKKHLTFGNGPHFCLGAPLARLEAKIALTTFLKKFKHIEAVPSFQLE 388 >3TKT-A nrPDB Length = 450 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 70/428 (16%), Positives = 145/428 (33%), Gaps = 63/428 (14%) Query: 71 LKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAER-------------ANRGFGIVFSNG 117 +P ++ ++ V +A D + R + +V + Sbjct: 70 HEPFWLVSSFDGVMKASKDNATFLNNPKSTVFTLRVGEMMAKAITGGSPHLVESLVQMDA 129 Query: 118 KKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNV 177 K ++RR + + + ++ +++ A ++ + + P +V Sbjct: 130 PKHPKLRRLTQDWFMPKNLAR--LDGEIRKIANEAIDRMLGAGEEGDFMALVAAPYPLHV 187 Query: 178 ICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLK-N 236 + I+ + + L L +++ N S + D P ++++ Sbjct: 188 VMQILGVP--PEDEPKMLFLTQQMFGG--------QDEDMNKSGLKDLPPEQISQIVAGA 237 Query: 237 VAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFG 296 VA + Y E + NP D + + + + Sbjct: 238 VAEFERYFAGLAAERRR-----NPTDDVATVIANAVV----DGEPMSDRDTAGYYIITAS 288 Query: 297 AGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQ 356 AG +TTS + A L L + P++ A+V+ DR+ +P +V E Sbjct: 289 AGHDTTSASSAGAALALARDPDLFARVKA---------------DRNLLP---GIVEEAI 330 Query: 357 RYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEG 416 R+ + + D + I G ++++ + HD +FP P FDP Sbjct: 331 RWTTPVQHFM-RTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTR----- 384 Query: 417 GNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGF 476 + + F AG C+G LA +E+ + L +L + L + V GF Sbjct: 385 ----PANRHLAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEPKRVNSTFVGGF 440 Query: 477 ASVPPFYQ 484 S+P ++ Sbjct: 441 KSLPMRWK 448 >2WIO-A nrPDB Length = 431 Score = 161 bits (408), Expect = 5e-40, Method: Composition-based stats. Identities = 74/420 (17%), Positives = 131/420 (31%), Gaps = 63/420 (15%) Query: 63 PVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKE 122 PV+ +G + + + V+ L D FS + + I + + + Sbjct: 62 PVWQDRYG---VWHVFRHADVQTVLRDTAT-FSSDPTRVIEGASPTPGMIHEIDPPEHRA 117 Query: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSII 182 +R+ + +E R+++ R L+ D +L I Sbjct: 118 LRKVVSSAFTPRTISD--LEPRIRDVTRSLL----ADAGESFDLVDVLAFPLPVTI---- 167 Query: 183 FHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKS 242 + L L +E S + I + P ++ + + + Sbjct: 168 --------VAELLGLPPMDHEQFGDWSGALVDIQMDDPTD----PALAERIADVLNPLTA 215 Query: 243 YILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETT 302 Y+ + E + +P D + L+ E E N + L AG TT Sbjct: 216 YLKARCAERRA-----DPGDDLISRLVLAEV----DGRALDDEEAANFSTALLLAGHITT 266 Query: 303 STTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLL 362 + L + L +HP E+ R+ A+V EV RY Sbjct: 267 TVLLGNIVRTLDEHPAHWDAAAEDPGRI------------------PAIVEEVLRYRPPF 308 Query: 363 PTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS 422 P + T + IP + + S D+ +P+ FDP Sbjct: 309 PQ-MQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSR-------KSGG 360 Query: 423 KYFMPFSAGKRICVGEALAGMELFLFLTSILQNF-NLKSLVDPKNLD-TTPVVNGFASVP 480 + F G C+G LA +E + L I+ F L D + L +V G +P Sbjct: 361 AAQLSFGHGVHFCLGAPLARLENRVALEEIIARFGRLTVDRDDERLRHFEQIVLGTRHLP 420 >3A1L-A nrPDB Length = 425 Score = 161 bits (407), Expect = 7e-40, Method: Composition-based stats. Identities = 65/349 (18%), Positives = 118/349 (33%), Gaps = 59/349 (16%) Query: 112 IVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILG 171 +VF + E+R SL+T + R+ E A L++ LR D Sbjct: 98 LVFLDPPHHTELR--SLLTTEFSPSIVTGLRPRIAELASALLDRLRAQ--RRPDLVEGFA 153 Query: 172 C-APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTH 230 P VI +++ +D +L + + + Sbjct: 154 APLPILVISALLG---IPEEDHTWLRANAVALQEASTTRARDGRGYA------------- 197 Query: 231 NKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENT 290 + Y +V + + + + S +++ + T Sbjct: 198 -RAEAASQEFTRYFRREVDRRGGDDRDDL---------LTLLVRARDTGSPLSVDGIVGT 247 Query: 291 AVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDA 350 V L AG ETT+ L A+L L H +V +++ E T A Sbjct: 248 CVHLLTAGHETTTNFLAKAVLTLRAHRDVLDELRTTPES------------------TPA 289 Query: 351 VVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPH 410 V E+ RY + ++ DI+ ++ IP+G+ ++ L S D FP+P++ D H Sbjct: 290 AVEELMRYDPPVQ-AVTRWAYEDIRLGDHDIPRGSRVVALLGSANRDPARFPDPDVLDVH 348 Query: 411 HFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLK 459 ++ + F G C+G LA E + L ++L Sbjct: 349 R---------AAERQVGFGLGIHYCLGATLARAEAEIGLRALLDGIPAL 388 >4YT3-A nrPDB Length = 410 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 75/409 (18%), Positives = 133/409 (32%), Gaps = 67/409 (16%) Query: 71 LKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFG-------IVFSNGKKWKEI 123 + YE VK L D S R ++ + G I S+ ++ Sbjct: 40 GTDTWNVFKYEDVKRVLSDYKHFSSVRKRTTISVGTDSEEGSVPEKIQITESDPPDHRKR 99 Query: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF 183 R + ++ E R+QE A L+ ++ + D L +P +I Sbjct: 100 RSLLAAAFTPRSL--QNWEPRIQEIADELIGQM--DGGTEIDIVASL-ASPLPIIV---- 150 Query: 184 HKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLK-NVAFMKS 242 + + + K + F P +KL + Sbjct: 151 -------------MADLMGVPSKDRLLFKKWVDTLFLPFDREKQEEVDKLKQVAAKEYYQ 197 Query: 243 YILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETT 302 Y+ V + + +N D I L FT + + T + + GAG ETT Sbjct: 198 YLYPIVVQKR----LNPADDIISDLLK-----SEVDGEMFTDDEVVRTTMLILGAGVETT 248 Query: 303 STTLRYALLLLL-KHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDL 361 S L + LL EV ++ E ++ V V E+ R+ Sbjct: 249 SHLLANSFYSLLYDDKEVYQELHENLDLV------------------PQAVEEMLRFR-F 289 Query: 362 LPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKK 421 L V D + +G ++++ +++ D + F +P + H Sbjct: 290 NLIKLDRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFTLNIHR--------PN 341 Query: 422 SKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTT 470 +K + F G C+G LA +E + LT+ L+ F V L+ Sbjct: 342 NKKHLTFGNGPHFCLGAPLARLEAKIALTAFLKKFKHIEAVPSFQLEEN 390 >4TRI-A nrPDB Length = 407 Score = 154 bits (390), Expect = 6e-38, Method: Composition-based stats. Identities = 68/423 (16%), Positives = 122/423 (28%), Gaps = 72/423 (17%) Query: 63 PVFTLYFGLKPIV---VLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKK 119 PVF GL + E E G R P + + Sbjct: 35 PVFRDRNGLAAATTYQAVLDAERNPELFSSTGGI---RPDQPGMPYMIDM------DDPQ 85 Query: 120 WKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVIC 179 R+ + + D + L++ + + I P VI Sbjct: 86 HLLRRKLVNAGFTRKRVMDK--VDSIGRLCDTLIDAVCERGECDF-VRDIAAPLPMAVIG 142 Query: 180 SIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAF 239 ++ L +L + S +D KL+ A Sbjct: 143 DMLG----------------VLPTERDMLLKWSDDLVCGLSSHVD--EAAIQKLMDTFAA 184 Query: 240 MKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGT 299 + + + + + P D + L+ E E + + + + + G Sbjct: 185 YTEFTKDVITKRRA-----EPTDDLFSVLVNSEVE----GQRMSDDEIVFETLLILIGGD 235 Query: 300 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYI 359 ETT TL LL+H + + +++ + E+ R+ Sbjct: 236 ETTRHTLSGGTEQLLRHRDQWDALVADVD------------------LLPGAIEEMLRWT 277 Query: 360 DLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNF 419 + ++ +T D F + G I++ S D F +P+ F Sbjct: 278 SPV-KNMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRIDR-------- 328 Query: 420 KKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVD--PKNLDTTPVVNGFA 477 + F G C+G LA +EL L +L+ L D P L V+G Sbjct: 329 -NPNSHVAFGFGTHFCLGNQLARLELRLMTERVLRRLPDLRLADDAPVPLRPANFVSGPE 387 Query: 478 SVP 480 S+P Sbjct: 388 SMP 390 >5LIV-A nrPDB Length = 450 Score = 154 bits (390), Expect = 6e-38, Method: Composition-based stats. Identities = 70/395 (17%), Positives = 131/395 (33%), Gaps = 69/395 (17%) Query: 97 RGIFPLAERANRGF----GIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCL 152 R + R + G+ G + +RR M + + E V+ + + Sbjct: 104 RDTATFSTRMFQAGILNGGLAAMQGDEHARMRRVYNMFFLPRAVSQYE-ERFVRPISEQV 162 Query: 153 VEELRKTKASP-CDPTFILGC-APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSS 210 V+ L P D P VI + F + ++ E++ ++ L Sbjct: 163 VDRLA---GKPRVDLLEDFAMELPRRVIGEL-----FGFPAEKLHETDERVRAMLRGL-- 212 Query: 211 PWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMK 270 + + P + + I E V+ +D D L + Sbjct: 213 -----------VRMHDPAAVAESQRAYGETLGLITEVVER--------ESRDTSDTLLGE 253 Query: 271 MEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERV 330 + + + + TIE+ + L G ETTS + + LL HP+ A+V+++ Sbjct: 254 ILRTLKAEHMD-TIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQDPS-- 310 Query: 331 IGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILIS 390 A + E R+ + V D++ + + GT + ++ Sbjct: 311 ----------------LLPAAIEEGMRWCP-SSFGVLRMVERDVRLDDQALSAGTVVCLA 353 Query: 391 LTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLT 450 + +D +P+PE++D N F G CVG LA ME + L Sbjct: 354 GIAGNYDETAYPSPEVYDIDRKPLPAANV--------FGGGAHFCVGAPLARMEARVGLQ 405 Query: 451 SILQNFNLKSLVDPKN-----LDTTPVVNGFASVP 480 ++L F V + V +G +P Sbjct: 406 ALLARFPGLRAVPEERPSFMYGAKDSVAHGPDKLP 440 >1Q5D-A nrPDB Length = 419 Score = 154 bits (390), Expect = 7e-38, Method: Composition-based stats. Identities = 70/441 (15%), Positives = 140/441 (31%), Gaps = 66/441 (14%) Query: 48 KDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERAN 107 +D ++ L + P+F G VL Y V D S AE ++ Sbjct: 26 EDPFPAIERLREA-TPIFYWDEG--RSWVLTRYHDVSAVFRDERFAVSREEWESSAEYSS 82 Query: 108 --------RGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKT 159 + +G+ + +R+ + + +Q L++ ++ Sbjct: 83 AIPELSDMKKYGLFGLPPEDHARVRKLVNPSFT--SRAIDLLRAEIQRTVDQLLDA--RS 138 Query: 160 KASPCDPTFILGC-APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNN 218 D P I ++ L + + +E + S + Sbjct: 139 GQEEFDVVRDYAEGIPMRAISAL-------------LKVPAECDEKFRRFGSATARALG- 184 Query: 219 FSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQ 278 ++ L+ +V + + + E + + N D + L Sbjct: 185 -VGLVPRVDEETKTLVASVTEGLALLHGVLDERRRNPLEN---DVLTMLLQAEA-----D 235 Query: 279 PSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC 338 S + + L + AGT+TT + +A+L LL+ PE V+ E Sbjct: 236 GSRLSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAEPG---------- 285 Query: 339 MQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDN 398 + EV R+ ++L D+++ I KG + + + S L D Sbjct: 286 --------LMRNALDEVLRFDNILRIGTVRFARQDLEYCGASIKKGEMVFLLIPSALRDG 337 Query: 399 KEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458 F P++FD + + + G +C G +LA +E + + +I + F Sbjct: 338 TVFSRPDVFDVRR---------DTSASLAYGRGPHVCPGVSLARLEAEIAVGTIFRRFPE 388 Query: 459 KSLVDPKNLDTTPVVNGFASV 479 L + P S+ Sbjct: 389 MKLKETPVFGYHPAFRNIESL 409 >6HQG-A nrPDB Length = 425 Score = 154 bits (389), Expect = 8e-38, Method: Composition-based stats. Identities = 64/391 (16%), Positives = 126/391 (32%), Gaps = 54/391 (13%) Query: 92 EEFSGRGIFPLAERANRGFGIVF--SNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEA 149 E FS L + A+ +F + K R+ + + +E ++E A Sbjct: 80 EVFSSEPTIVLPDPADDFTLPMFIAMDPPKHDVQRKTVQPIVAPNHLAY--LEPIIRERA 137 Query: 150 RCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILS 209 ++++L + + + + +F F ++D++ L + S Sbjct: 138 GKILDDLP--IGEEINWVDKVSIELTTMTLATLFD--FPWEDRRKLTFWSDVAT-----S 188 Query: 210 SPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLM 269 +P I P + + L Y + E + P+ + L Sbjct: 189 APESGILGTTDP--EEHENLRRQTLFECV---DYFMRLWNERVNA----PPKPDLISMLA 239 Query: 270 KMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIER 329 E K+ + L G +TT T+ ++L L ++P+ K++E Sbjct: 240 HGESTKN-----MDRMEYLGNLILLIVGGNDTTRNTISGSVLALHQNPDQDRKLRENPGL 294 Query: 330 VIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILI 389 + A+V E R+ L + D + I +G + + Sbjct: 295 I------------------PAMVSETIRWQTPL-AYMRRRAKRDFELGGKTIREGDKVAM 335 Query: 390 SLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFL 449 S D + P + + + + F G CVG LA ++L + Sbjct: 336 WYVSGNRDEEVIDRPNDYWIER--------PRVRQHLSFGFGVHRCVGNRLAELQLKIIW 387 Query: 450 TSILQNFNLKSLVDPKNLDTTPVVNGFASVP 480 IL F +V P + V G+ +P Sbjct: 388 EEILARFPRLEVVGPPRRVYSSFVKGYEELP 418 >6F88-A nrPDB Length = 400 Score = 154 bits (389), Expect = 9e-38, Method: Composition-based stats. Identities = 70/395 (17%), Positives = 131/395 (33%), Gaps = 69/395 (17%) Query: 97 RGIFPLAERANRGF----GIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCL 152 R + R + G+ G + +RR M + + E V+ + + Sbjct: 54 RDTATFSTRMFQAGILNGGLAAMQGDEHARMRRVYNMFFLPRAVSQYE-ERFVRPISEQV 112 Query: 153 VEELRKTKASP-CDPTFILGC-APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSS 210 V+ L P D P VI + F + ++ E++ ++ L Sbjct: 113 VDRLA---GKPRVDLLEDFAMELPRRVIGEL-----FGFPAEKLHETDERVRAMLRGL-- 162 Query: 211 PWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMK 270 + + P + + I E V+ +D D L + Sbjct: 163 -----------VRMHDPAAVAESQRAYGETLGLITEVVER--------ESRDTSDTLLGE 203 Query: 271 MEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERV 330 + + + + TIE+ + L G ETTS + + LL HP+ A+V+++ Sbjct: 204 ILRTLKAEHMD-TIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARVRQDPS-- 260 Query: 331 IGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILIS 390 A + E R+ + V D++ + + GT + ++ Sbjct: 261 ----------------LLPAAIEEGMRWCPSN-FGVLRMVERDVRLDDQALSAGTVVCLA 303 Query: 391 LTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLT 450 + +D +P+PE++D N F G CVG LA ME + L Sbjct: 304 GIAGNYDETAYPSPEVYDIDRKPLPAANV--------FGGGAHFCVGAPLARMEARVGLQ 355 Query: 451 SILQNFNLKSLVDPKN-----LDTTPVVNGFASVP 480 ++L F V + V +G +P Sbjct: 356 ALLARFPGLRAVPEERPSFMYGAKDSVAHGPDKLP 390 >5Z9I-A nrPDB Length = 398 Score = 154 bits (388), Expect = 1e-37, Method: Composition-based stats. Identities = 66/372 (17%), Positives = 128/372 (34%), Gaps = 55/372 (14%) Query: 116 NGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPC 175 + K + +R + K +E RV L++ + D Sbjct: 79 DPPKHRRLRGLVDHAFTPSLVAK--MESRVHGIIHELLDGVEGKSQ--FDLVAEFAAPLP 134 Query: 176 NVICSIIFHKRFDYKDQQ-FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLL 234 ++ S + D+ F M+K+ + + SP + +K L Sbjct: 135 LIMISDLLG--VPESDRALFRQWMDKMLDGSEKFESPET---------VLEQEEELHKEL 183 Query: 235 KNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDL 294 + + M+ Y E+ E ++ P++ + L+ E + + N A L Sbjct: 184 ELLWEMRDYWHERAAESRK-----RPREDLISQLVHAEV----DGQKLNDSQISNIANRL 234 Query: 295 FGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHE 354 G TT+ + +L L + A+V+ DRS +P A++ E Sbjct: 235 LVNGHLTTAMLIANTMLCLDAFSDQDARVRA---------------DRSLVP---ALLEE 276 Query: 355 VQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLD 414 RY+ + + A +++ +IPK +L+ + D ++F P++FD Sbjct: 277 SMRYMSPI-CGVGRATNSEVEVAGTVIPKDQLLLVWTGAANRDERQFEKPDVFD------ 329 Query: 415 EGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSL--VDPKNLDTTPV 472 + + F G C+G LA ME + +L +P Sbjct: 330 ---AGRSPNAHLGFGRGIHFCLGRQLARMESKAAVEILLDRLPTLRADPANPPTFLQVVD 386 Query: 473 VNGFASVPPFYQ 484 +G A++P Q Sbjct: 387 ASGVATLPVVTQ 398 >5EX8-A nrPDB Length = 424 Score = 152 bits (385), Expect = 2e-37, Method: Composition-based stats. Identities = 63/398 (15%), Positives = 122/398 (30%), Gaps = 71/398 (17%) Query: 71 LKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFG-IVFSNGKKWKEIRRFSLM 129 + + G + V++ L ++FS R ++ G + + + +RR + Sbjct: 78 GRTAWLATGIDEVRQVLGS--DKFSARLLYGGTAAGITWPGFLTQYDPPEHTRLRRMVVP 135 Query: 130 TLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILG-CAPCNVICSIIFHKRFD 188 + M + RV++ + ++ + + P D G C + R D Sbjct: 136 AFSHRRM--QKFRPRVEQIVQDSLDTIE-SLGGPVDFVPHFGWAIATPATCDFLGIPRDD 192 Query: 189 YKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKV 248 D + L + ++ K + + + Sbjct: 193 QADLARILLASRT-----------------------------DRSDKRRTAAGNKFMTYM 223 Query: 249 KEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRY 308 K+H + D T L A + GA + + L Sbjct: 224 KQHVAQSRRGSGDDLFGIV-------GRENGDAITDAELTGVAAFVMGAAADQVARLLAA 276 Query: 309 ALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPH 368 L+++ P A ++E+ E V P D E RY+ + P Sbjct: 277 GAWLMVEQPAQFALLREKPETV------PEWLD------------ETMRYLTTDEKTHPR 318 Query: 369 AVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPF 428 T D++ N L+ G T+ SL + + FD E + F Sbjct: 319 VATQDVRIGNQLVKAGDTVTCSLLAANR-PNYPSAEDEFDITREKAE---------HLAF 368 Query: 429 SAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKN 466 G C+G A+A + + + ++ F L DP+ Sbjct: 369 GHGIHHCLGRAMAELMFKVSIPALAHRFPTLRLADPQR 406 >3OO3-A nrPDB Length = 384 Score = 152 bits (384), Expect = 4e-37, Method: Composition-based stats. Identities = 69/429 (16%), Positives = 137/429 (31%), Gaps = 78/429 (18%) Query: 49 DISKSLTNLSKVYGPVFTL----YFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAE 104 D L K GP+ + ++ G++ V+ L D S R + A+ Sbjct: 13 DPVPEFEELQKA-GPLHEYDTEPGMDGRKQWLVTGHDEVRAILADHERFSSMRPVDDEAD 71 Query: 105 RANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPC 164 RA + + +RR + + R++E +++ + +P Sbjct: 72 RALLPGILQAYDPPDHTRLRR--TVAPAYSARRMERLRPRIEEIVEECLDDFE-SVGAPV 128 Query: 165 DPTFILGC-APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPII 223 D P + C + R D + ++ + E+ Sbjct: 129 DFVRHAAWPIPAYIACEFLGVPRDD--QAELSRMIRESRES------------------- 167 Query: 224 DYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFT 283 + L + + + + + +D D + + +E +E + Sbjct: 168 ---RLPRQRTLSGLG---------IVNYTKRLTSGKRRDPGDGMIGVIVREH---GAEIS 212 Query: 284 IESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRS 343 E L A E + L A+LLL+ HP+ A ++E+ E + Sbjct: 213 DEELAGLAEGNLIMAAEQMAAQLAVAVLLLVTHPDQMALLREKPELI------------- 259 Query: 344 HMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPN 403 D+ EV R+ ++ P D++ I G + S+ + Sbjct: 260 -----DSATEEVLRHASIVEAPAPRVALADVRMAGRDIHAGDVLTCSMLATNRAP----- 309 Query: 404 PEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVD 463 + FD + M F G C+G LA ++L + L +++ F L Sbjct: 310 GDRFDITR---------EKATHMAFGHGIHHCIGAPLARLQLRVALPAVVGRFPSLRLAV 360 Query: 464 P-KNLDTTP 471 P ++L P Sbjct: 361 PEEDLRFKP 369 >2FR7-A nrPDB Length = 412 Score = 151 bits (380), Expect = 1e-36, Method: Composition-based stats. Identities = 61/369 (16%), Positives = 118/369 (31%), Gaps = 61/369 (16%) Query: 112 IVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILG 171 I+ ++ R L M + + D A ++EL + + Sbjct: 99 ILEADPPAHTRTRAVLSKVLSPATM--KRLRDGFAAAADAKIDELLARGGNIDAIADLAE 156 Query: 172 CAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHN 231 P +V F + M E + L + N F G N Sbjct: 157 AYPLSV----------------FPDAMGLKQEGRENLLPYAGLVFNAF--------GPPN 192 Query: 232 KLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTA 291 +L ++ + V E + ++ P F C + E T E Sbjct: 193 ELRQSAIERSAPHQAYVAEQCQRPNL-APGGFGACI------HAFSDTGEITPEEAPLLV 245 Query: 292 VDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAV 351 L AG +TT + A+ L + P+ A+++ + Sbjct: 246 RSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRADPS------------------LARNA 287 Query: 352 VHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHH 411 E R+ + + T D++ I +G +L+ L S D + + +P+ +D Sbjct: 288 FEEAVRFESPVQ-TFFRTTTRDVELAGATIGEGEKVLMFLGSANRDPRRWDDPDRYDITR 346 Query: 412 FLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTP 471 K+ + F +G +CVG+ +A +E + L ++ + + P Sbjct: 347 ---------KTSGHVGFGSGVHMCVGQLVARLEGEVVLAALARKVAAIEIAGPLKRRFNN 397 Query: 472 VVNGFASVP 480 + G S+P Sbjct: 398 TLRGLESLP 406 >2WM5-A nrPDB Length = 435 Score = 150 bits (378), Expect = 1e-36, Method: Composition-based stats. Identities = 62/413 (15%), Positives = 133/413 (32%), Gaps = 65/413 (15%) Query: 75 VVLHGYEAVKEALIDLGEEFSGRGIFPLAE----RANRGFGIVFSNGKKWKEIRRFSLMT 130 L Y+ V A + FS + + A ++ + + + +R Sbjct: 77 WALTKYDDVFYA-SRHPDIFSSYPNITINDQTPELAEYFGSMIVLDDPRHQRLRSIVSRA 135 Query: 131 LRNFGMGKRSIEDRVQEEARCLVEEL-RKTKASPCDPTFIL-GCAPCNVICSIIFHKRFD 188 + + IE V++ A LV + D L G P +IC ++ + D Sbjct: 136 FTPKVVAR--IEAAVRDRAHRLVSSMIANNPDRQADLVSELAGPLPLQIICDMMGIPKAD 193 Query: 189 YKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKV 248 ++ + IL + +F ++ ++ A + +Y Sbjct: 194 HQ--------RIFHWTNVILGFGDPDLATDF-----------DEFMQVSADIGAYATALA 234 Query: 249 KEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRY 308 ++ + +N+ D + E + + + + L AG ETT + + Sbjct: 235 EDRR----VNHHDDLTSSLV-----EAEVDGERLSSREIASFFILLVVAGNETTRNAITH 285 Query: 309 ALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPH 368 +L L ++PE + + + V E+ R+ + + Sbjct: 286 GVLALSRYPEQRDRWWSDFDG-----------------LAPTAVEEIVRWASPV-VYMRR 327 Query: 369 AVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPF 428 +T DI+ R + G + + S D +F +P FD + F Sbjct: 328 TLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFDLAR---------NPNPHLGF 378 Query: 429 -SAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 480 G C+G LA E+ + + + + + ++G ++P Sbjct: 379 GGGGAHFCLGANLARREIRVAFDELRRQMPDVVATEEPARLLSQFIHGIKTLP 431 >2NZA-A nrPDB Length = 413 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 81/472 (17%), Positives = 143/472 (30%), Gaps = 83/472 (17%) Query: 21 RQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYF--GLKPIVVLH 78 ++ G+ PP P L + + L L GP+ + G + Sbjct: 4 ETTTLTGQSPPPVRDWP----ALDLDGPEFDPVLAELM-REGPLTRVRLPHGEGWAWLAT 58 Query: 79 GYEAVKEALIDLG---EEFSGRGIFPLAERA-NRGFGIVFSNGKKWKEIRRFSLMTLRNF 134 Y+ VK D E + R I LA R + F++ +RR F Sbjct: 59 RYDDVKAITNDPRFGRAEVTQRQITRLAPHFKPRPGSLAFADQPDHNRLRRAVAGA---F 115 Query: 135 GMG-KRSIEDRVQEEARCLVEELRKTKASPCDPTF-ILGCAPCNVICSIIFHKRFDYKDQ 192 +G + + R QE LV+ + P D +L P V+ ++ D+ Sbjct: 116 TVGATKRLRPRAQEILDGLVDGILAE-GPPADLVERVLEPFPIAVVSEVMG---VPAADR 171 Query: 193 QFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQ 252 + + S QI + G + + +I E V+ Sbjct: 172 ER-------------VHSWTRQIIST--------SGGAEAAERAKRGLYGWITETVR--- 207 Query: 253 ESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLL 312 + + D + + E A L G E + + L L Sbjct: 208 -ARAGSEGGDVYSMLGAAVGR------GEVGETEAVGLAGPLQIGG-EAVTHNVGQMLYL 259 Query: 313 LLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDL-LPTSLPHAVT 371 LL E+ A+++E + E+ R+I L Sbjct: 260 LLTRRELMARMRERPGA------------------RGTALDELLRWISHRTSVGLARIAL 301 Query: 372 CDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAG 431 D++ I G + +S + D FP+P+ D + + G Sbjct: 302 EDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDLDR---------DPNPHLAYGNG 352 Query: 432 KRICVGEALAGMELFLFLTSILQNFNLKSLVDPKN---LDTTPVVNGFASVP 480 C G LA M+ L + ++L+ L P ++ G ++P Sbjct: 353 HHFCTGAVLARMQTELLVDTLLERLPGLRLAVPAEQVAWRRKTMIRGPRTLP 404 >2X9P-A nrPDB Length = 404 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 69/438 (15%), Positives = 128/438 (29%), Gaps = 80/438 (18%) Query: 54 LTNLSKVYGPVFTLYF-GLKPIVVLHGYEAVKEALIDL--GEEFSGRGIFP-LAERANRG 109 L + GP+ + ++ + +K+ L D G Sbjct: 31 LLRALQDRGPIHRVRTPAGDEAWLVTRHAELKQLLHDERIGRTHPDPPSAAQYVRSPFLD 90 Query: 110 FGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIE--DRVQEEARCLVEELRKTKASPCDPT 167 I ++ + + + L +R +E +V+E A L++ + P D Sbjct: 91 LLISDADAESGRRQHAETRRLLTPLFSARRVLEMQPKVEEAADTLLDAFIA-QGPPGDLH 149 Query: 168 FILGC-APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYF 226 L V+C +I P + + + Sbjct: 150 GELTVPFALTVLCEVI--------------------------GVPPQRRAELTTLLAGIA 183 Query: 227 PGTHNK-LLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIE 285 + ++ + Y+ V+ + D I E T + Sbjct: 184 KLDDREGAVRAQDDLFGYVAGLVEHKRAEPGP----DIISRL----------NDGELTED 229 Query: 286 SLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHM 345 + + A+ L AG ++ ++ + ++LL HP+ A + + Sbjct: 230 RVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPDQRAAALADPD----------------- 272 Query: 346 PYTDAVVHEVQRYIDLLPTSLP-HAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNP 404 V EV R + LP + D++F I G +L L D + F P Sbjct: 273 -VMARAVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFDERAFTGP 331 Query: 405 EMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDP 464 E FD + + F G C+G LA +EL T + P Sbjct: 332 EEFD---------AARTPNPHLTFGHGIWHCIGAPLARLELRTMFTKLFTRLPELRPELP 382 Query: 465 ---KNLDTTPVVNGFASV 479 L + GFA + Sbjct: 383 VEQLRLKEGQLSGGFAEL 400 >2RFC-A nrPDB Length = 343 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 72/413 (17%), Positives = 133/413 (32%), Gaps = 91/413 (22%) Query: 74 IVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVF--SNGKKWKEIRRFSLMTL 131 ++ Y VK L++ + FS R + GI F + + KE R S Sbjct: 12 AWHVYKYSDVKHVLMN-DKIFSSNP----GNRYSNAGGISFITMDNPEHKEFRDIS---A 63 Query: 132 RNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILG----CAPCNVICSIIFHKRF 187 F + ++ + + +EE D I+ P N+I Sbjct: 64 PYF------LPSKINDY-KDFIEETSNDLIKNIDNKDIISEYAVRLPVNIIS-------- 108 Query: 188 DYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEK 247 KIL P + F DY G NK +N ++ + ++ + Sbjct: 109 ------------------KILGIPDSDM-PLFKLWSDYIIG--NKRDENFNYVNNRMVSR 147 Query: 248 VKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLR 307 + E +S ++ + + + T++ + L G ETT+ + Sbjct: 148 LLEIFKSDSHG---------IINVLAGSSLKNRKLTMDEKIKYIMLLIIGGNETTTNLIG 198 Query: 308 YALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLP 367 + ++ ++P++ + V E RY + Sbjct: 199 NMIRVIDENPDIID---------------------DALKNRSGFVEETLRYYSPIQFLPH 237 Query: 368 HAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMP 427 D N I KG +++ L S D F P++F + + Sbjct: 238 RFAAEDSYINNKKIKKGDQVIVYLGSANRDETFFDEPDLFKIGRR----------EMHLA 287 Query: 428 FSAGKRICVGEALAGMELFLFLTSILQNF-NLKSLVDPKNLDTTPVVNGFASV 479 F G +C+G LA +E + L IL +F +K L +V G+ + Sbjct: 288 FGIGIHMCLGAPLARLEASIALNDILNHFKRIKIDYKKSRLLDNKMVLGYDKL 340 >3RWL-A nrPDB Length = 426 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 45/228 (19%), Positives = 82/228 (35%), Gaps = 35/228 (15%) Query: 253 ESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLL 312 E ++ + D I T E + L G +TT ++ +L Sbjct: 227 ERVNKDPGNDLISML------AHSPATRNMTPEEYLGNVLLLIVGGNDTTRNSMTGGVLA 280 Query: 313 LLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTC 372 L K+P+ AK++ V + +V E+ R+ L + Sbjct: 281 LHKNPDQFAKLKANPALV------------------ETMVPEIIRWQTPLAH-MRRTAIA 321 Query: 373 DIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGK 432 D + I KG +++ S D++ PE F + + + F G Sbjct: 322 DSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDR--------PRPRQHLSFGFGI 373 Query: 433 RICVGEALAGMELFLFLTSILQNF-NLKSLVDPKNLDTTPVVNGFASV 479 CVG LA M+L + IL F ++ + +P+ + + V G+A + Sbjct: 374 HRCVGNRLAEMQLRILWEEILTRFSRIEVMAEPERVRSN-FVRGYAKM 420 >6CVC-A nrPDB Length = 433 Score = 145 bits (366), Expect = 4e-35, Method: Composition-based stats. Identities = 58/419 (13%), Positives = 129/419 (30%), Gaps = 65/419 (15%) Query: 69 FGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAE----RANRGFGIVFSNGKKWKEIR 124 K L ++ + E F + + A ++ + + + +R Sbjct: 68 TAGKGHWALTKHDDIH-FASRHPEIFHSSPNIVIHDQTPELAEYFGSMIVLDDPRHQRLR 126 Query: 125 RFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKT--KASPCDPTFILGCAPCNVICSII 182 + + IE V+E A LV + + + + G P +IC ++ Sbjct: 127 SIVSRAFTPKVVAR--IEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQIICDMM 184 Query: 183 FHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKS 242 +D + + + IL + +F ++ L+ + Sbjct: 185 G---IPEEDHE-----QIFHWTNVILGFGDPDLTTDF-----------DEFLQVSMAIGG 225 Query: 243 YILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETT 302 Y + + +N+ D + E + + + L AG ETT Sbjct: 226 YATALADDRR----VNHHGDLTTSLV-----EAEVDGERLSSSEIAMFFILLVVAGNETT 276 Query: 303 STTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLL 362 + + +L L ++P+ AK + + V E+ R+ + Sbjct: 277 RNAISHGMLALSRYPDERAKWWSDFDG-----------------LAATAVEEIVRWASPV 319 Query: 363 PTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS 422 + ++ D+ R + G + + S D ++F +P FD Sbjct: 320 -VYMRRTLSQDVDLRGTKMAAGDKVTLWYCSANRDEEKFADPWTFDVTR---------NP 369 Query: 423 KYFMPF-SAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 480 + F G C+G LA E+ + + + + + ++G +P Sbjct: 370 NPQVGFGGGGAHFCLGANLARREIRVVFDELRRQMPDVVATEEPARLLSQFIHGIKRLP 428 >2XKR-A nrPDB Length = 398 Score = 145 bits (365), Expect = 5e-35, Method: Composition-based stats. Identities = 67/400 (16%), Positives = 123/400 (30%), Gaps = 73/400 (18%) Query: 89 DLGEEFSG----RGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDR 144 E FS R P ++ + R+ + + E Sbjct: 54 RQPELFSNAGGIRPDQPALP------MMIDMDDPAHLLRRKLVNAGFTRKRVKDK--EAS 105 Query: 145 VQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFHKRFDYKDQQFLNLMEKLNE 203 + L++ + + CD L P VI ++ R + +D FL + L Sbjct: 106 IAALCDTLIDAVCERGE--CDFVRDLAAPLPMAVIGDML-GVRPEQRD-MFLRWSDDLVT 161 Query: 204 NIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDF 263 + +F +D F ++ +A ++ +P D Sbjct: 162 FLS-----SHVSQEDFQITMDAFAAYNDFTRATIAARRA----------------DPTDD 200 Query: 264 IDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKV 323 + L+ E + + L + + G ETT TL LL++ + + Sbjct: 201 LVSVLVSSEV----DGERLSDDELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLL 256 Query: 324 QEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPK 383 Q + + E+ R+ + ++ +T D +F + Sbjct: 257 QRDPS------------------LLPGAIEEMLRWTAPV-KNMCRVLTADTEFHGTALCA 297 Query: 384 GTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGM 443 G +++ S D F PE FD + F G C+G LA + Sbjct: 298 GEKMMLLFESANFDEAVFCEPEKFDVQR---------NPNSHLAFGFGTHFCLGNQLARL 348 Query: 444 ELFLFLTSILQNFNLKSLVDPKN---LDTTPVVNGFASVP 480 EL L +L+ LV + L V+G S+P Sbjct: 349 ELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMP 388 >5FYF-A nrPDB Length = 470 Score = 144 bits (364), Expect = 6e-35, Method: Composition-based stats. Identities = 59/410 (14%), Positives = 135/410 (32%), Gaps = 54/410 (13%) Query: 73 PIVVLHGYEAVKEALIDLGEE-FSGRGIFPLAERANRGFGIVF--SNGKKWKEIRRFSLM 129 P + +E + +D + FS L + +F + K R Sbjct: 104 PFWSVTRFEDI--LFVDKSHDLFSAEPQIILGDPPEGLSVEMFIAMDPPKHDVQRSSVQG 161 Query: 130 TLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDY 189 + + + +E ++ +++ L K P + + + + + ++ Sbjct: 162 VVAPKNL--KEMEGLIRSRTGDVLDSLPTDK--PFNWVPAVSKELTGRMLATLLDFPYEE 217 Query: 190 KDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVK 249 + + + +++ + F D + ++L ++ K Sbjct: 218 RHK-LVEWSDRMAGAASATGGEFADENAMFDDAAD-MARSFSRLWRD------------K 263 Query: 250 EHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYA 309 E + + D I L ++ K L G +TT ++ Sbjct: 264 EARRAAGEEPGFDLI-SLLQSNKETKDLINRPM---EFIGNLTLLIVGGNDTTRNSMSGG 319 Query: 310 LLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHA 369 L+ + + P K++ + E + +V E+ R+ L + Sbjct: 320 LVAMNEFPREFEKLKAKPELI------------------PNMVSEIIRWQTPL-AYMRRI 360 Query: 370 VTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFS 429 D++ I KG +++ S D ++F NP+ F K ++ M F Sbjct: 361 AKQDVELGGQTIKKGDRVVMWYASGNRDERKFDNPDQFIIDR--------KDARNHMSFG 412 Query: 430 AGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASV 479 G C+G LA ++L + IL+ F+ +V+ + V G++ + Sbjct: 413 YGVHRCMGNRLAELQLRILWEEILKRFDNIEVVEEPERVQSNFVRGYSRL 462 >1F4U-A nrPDB Length = 368 Score = 144 bits (363), Expect = 9e-35, Method: Composition-based stats. Identities = 68/441 (15%), Positives = 142/441 (32%), Gaps = 92/441 (20%) Query: 50 ISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALI---DLGEEFSG--------RG 98 + + + K PV+ Y G I + Y KE L + +G R Sbjct: 1 MYDWFSEMRKK-DPVY--YDGN--IWQVFSYRYTKEVLNNFSKFSSDLTGYHERLEDLRN 55 Query: 99 IFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRK 158 + R + ++ S+ E+R S + +++E ++E R L++ + Sbjct: 56 GKIRFDIPTR-YTMLTSDPPLHDELRSMSADIFSPQKL--QTLETFIRETTRSLLDSIDP 112 Query: 159 TKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNN 218 + + P VI I+ +D++ K E +++ + Sbjct: 113 REDDIV--KKLAVPLPIIVISKILG---LPIEDKE------KFKEWSDLVAFRLGK---- 157 Query: 219 FSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQ 278 PG +L K + Y+ D E Sbjct: 158 --------PGEIFELGKKYLELIGYVK-------------------DHLNSGTEVVSRVV 190 Query: 279 PSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC 338 S + + L AG ETT+ + +++ + + +++EE Sbjct: 191 NSNLSDIEKLGYIILLLIAGNETTTNLISNSVIDFTRF-NLWQRIREE------------ 237 Query: 339 MQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDN 398 + E RY + ++ +K + I +G + + + S D Sbjct: 238 -------NLYLKAIEEALRYSPPVMRTV-RKTKERVKLGDQTIEEGEYVRVWIASANRDE 289 Query: 399 KEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458 + F + E F P + F +G +C+G LA +E + + + F Sbjct: 290 EVFHDGEKFIPDR---------NPNPHLSFGSGIHLCLGAPLARLEARIAIEEFSKRFRH 340 Query: 459 KSLVDPKNLDTTPVVNGFASV 479 ++D + + V+NG+ + Sbjct: 341 IEILDTEKVPNE-VLNGYKRL 360 >6HQW-A nrPDB Length = 445 Score = 144 bits (363), Expect = 9e-35, Method: Composition-based stats. Identities = 57/373 (15%), Positives = 114/373 (30%), Gaps = 44/373 (11%) Query: 111 GIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFIL 170 GI + + + ++ + L F R + T A + + Sbjct: 106 GITIGDPPEDVDPQKLAERQLPMFIAMDRP-----DHTGQRRTVAPAFTPAKMVEMEAEI 160 Query: 171 GCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTH 230 +V+ S+ + +RFD+ D+ + L + PW + D+ Sbjct: 161 RRRTASVLDSLPWGERFDWVDKVSIEL--TTGMLAILFGFPWAD-RRLLTFWSDWAGDVE 217 Query: 231 NKLLKNVAFMK----SYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIES 286 L + +A + + + + P + ++ E H + + Sbjct: 218 LTLARELADTRFGFLGEMAHYFQRLWGARMQAPPSGDLISMMIHSEAMNH-----MSPQE 272 Query: 287 LENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMP 346 V L G +TT T+ + L K P+ ++ + + Sbjct: 273 FMGNLVLLIVGGNDTTRNTMSGIVHALDKFPDQRELLERDASLI---------------- 316 Query: 347 YTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEM 406 V E RY+ L + T D + I G +++ S D F NP+ Sbjct: 317 --PNAVQECIRYVTPLAH-MRRTATADTELFGNQIKAGEKVILWYISANRDETVFENPDK 373 Query: 407 FDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKN 466 ++ + F G CVG LA ++L + L + + + Sbjct: 374 LMVDR--------PNARRHLSFGHGIHRCVGARLAELQLRILLEEMHERRMRVRVAGEVE 425 Query: 467 LDTTPVVNGFASV 479 V+GF + Sbjct: 426 RVRANFVHGFRKL 438 >1UE8-A nrPDB Length = 367 Score = 141 bits (355), Expect = 8e-34, Method: Composition-based stats. Identities = 57/330 (17%), Positives = 120/330 (36%), Gaps = 46/330 (13%) Query: 152 LVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSP 211 L +ELR A +P+ + V ++ D++F + ++ S Sbjct: 75 LHDELRNLTADAFNPSNLPVDFVREVTVKLL-----SELDEEFDVIESFAIPLPILVISK 129 Query: 212 WIQICNNFSPIIDYFPGTHNKLLKN--VAFMKSYILEKVKEHQESMDMNNPQDFIDCFLM 269 + I + + D+ +L + + + LE + ++ +D ++ +D Sbjct: 130 MLGINPDVKKVKDWSDLVALRLGRADEIFSIGRKYLELISFSKKELDSRKGKEIVDL--- 186 Query: 270 KMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIER 329 S + E + L AG ETT+ + A IE Sbjct: 187 ----TGKIANSNLSELEKEGYFILLMIAGNETTTNLIGNA-----------------IED 225 Query: 330 VIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILI 389 N ++++ + V E R+ + ++ +K R+ +I +G + + Sbjct: 226 FTLYNSWDYVREKGALK----AVEEALRFSPPVMRTI-RVTKEKVKIRDQVIDEGELVRV 280 Query: 390 SLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFL 449 + S D + F +P+ F P + F +G +C+G LA +E + L Sbjct: 281 WIASANRDEEVFKDPDSFIPDR---------TPNPHLSFGSGIHLCLGAPLARLEARIAL 331 Query: 450 TSILQNFNLKSLVDPKNLDTTPVVNGFASV 479 + F +K +V + +D V+NG+ + Sbjct: 332 EEFAKKFRVKEIVKKEKIDNE-VLNGYRKL 360 >5HIW-A nrPDB Length = 398 Score = 140 bits (354), Expect = 9e-34, Method: Composition-based stats. Identities = 84/448 (18%), Positives = 151/448 (33%), Gaps = 76/448 (16%) Query: 41 NILQIGIKDISKS---LTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGR 97 N+ KD S L ++ + F G+ VVL G + V A++ E FS R Sbjct: 6 NLFSFTSKDPSAFGIHLAAAAREHSVYFDEGLGVP--VVLRGADVV--AVLRDSETFSTR 61 Query: 98 GIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEEL- 156 + +V G+ +RR L + + E V AR +VE L Sbjct: 62 ----TYDTGIMKGALVTLGGEAHTRMRRLFNAVLSPRVISRYE-EATVTPVARRVVERLV 116 Query: 157 RKTKASPCDPTFILGCAPCNVICSIIFH---KRFDYKDQQFLNLMEKLNENIKILSSPWI 213 RK +A D + + S +F +R D ++ + Sbjct: 117 RKERAELFD---DFAISMPMGVTSALFGLPEERIAENDALIRKMIRSV------------ 161 Query: 214 QICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEK 273 ++ P + A M++ + E + ++ +P D + + + Sbjct: 162 --------VMPQDPVVVAEGRSAHAAMEAQLREIAER-----EVAHPSDTLLGEIARAIV 208 Query: 274 EKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGR 333 + +E+ E + L ETTS L L+ LL HP+ +++++ Sbjct: 209 AEGLGG----VEACEGVVLTLILGSYETTSWMLANLLVALLAHPDAMNQLRQQPS----- 259 Query: 334 NRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTS 393 + E R+ + V + + GT + +SL + Sbjct: 260 -------------LLPQAIEESTRWCSSA-AGIVRFVEREATIGGETLAAGTILYLSLIA 305 Query: 394 VLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSIL 453 +D + +P PE FD H + + F G CVG LA ME + ++ +L Sbjct: 306 RHYDEEIYPRPETFDIHR---------RPVGMLNFGGGLHYCVGAPLARMEARVGVSLLL 356 Query: 454 QNFNLKSLVDPKNLDTTPVVNGFASVPP 481 + F + G A+ P Sbjct: 357 ERFPALRADPTVQPTFSTAPRGAAAFGP 384 >4DO1-A nrPDB Length = 410 Score = 139 bits (351), Expect = 2e-33, Method: Composition-based stats. Identities = 72/456 (15%), Positives = 143/456 (31%), Gaps = 69/456 (15%) Query: 30 PPGPTPLPVIG-NILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALI 88 PP + +P + + + D + GPV +Y + + Y V L Sbjct: 13 PPNDSTIPHLAIDPFSLDFFDDPYPDQQTLRDAGPV--VYLDKWNVYGVARYAEVHAVLN 70 Query: 89 DLGEEFSGRGI----FPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDR 144 D S RG+ F + I+ ++ R L M ++I D Sbjct: 71 DPTTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRPRAVLSKVLSPATM--KTIRDG 128 Query: 145 VQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNEN 204 A V+EL + + P +V F + M E Sbjct: 129 FAAAADAKVDELL-QRGCIDAIADLAEAYPLSV----------------FPDAMGLKQEG 171 Query: 205 IKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFI 264 + L + N F P ++ +E+ HQ ++ + + Sbjct: 172 REHLLPYAGLVFNAFGP---------------PNELRQTAIERSAPHQAYVNEQCQRPNL 216 Query: 265 DCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQ 324 E T + L AG +TT + A+ L + P +++ Sbjct: 217 APGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLR 276 Query: 325 EEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKG 384 + E R+ + + T +++ +I +G Sbjct: 277 SDP------------------TLARNAFEEAVRFESPVQ-TFFRTTTREVELGGAVIGEG 317 Query: 385 TTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGME 444 +L+ L S D + + +P+++D K+ + F +G +CVG+ +A +E Sbjct: 318 EKVLMFLGSANRDPRRWSDPDLYDITR---------KTSGHVGFGSGVHMCVGQLVARLE 368 Query: 445 LFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 480 + L+++ + + P + G S+P Sbjct: 369 GEVMLSALARKVAAIDIDGPVKRRFNNTLRGLESLP 404 >5HDI-A nrPDB Length = 404 Score = 139 bits (351), Expect = 2e-33, Method: Composition-based stats. Identities = 70/427 (16%), Positives = 126/427 (29%), Gaps = 76/427 (17%) Query: 68 YFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFG--------------IV 113 + G++AV EA I E+FS + G + Sbjct: 34 RIANSDFYAVCGWDAVNEA-IGRPEDFSS-NLTATMTYTAEGTAKPFEMDPLGGPTHVLA 91 Query: 114 FSNGKKWKEIRRFSLMTLRNFGMGKRSIED-RVQEEARCLVEELRKTKASPCDPTFILGC 172 ++ R+ L L + R +E VQ R V+ ++ + Sbjct: 92 TADDPAHAVHRKLVLRHLAAKRI--RVMEQFTVQAADRLWVDGMQD--GCIEWMGAMANR 147 Query: 173 APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNK 232 P V+ +I D L++ ++L + + Sbjct: 148 LPMMVVAELI-----GLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGV---------- 192 Query: 233 LLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAV 292 + + YI E+ +P+D + L E + + V Sbjct: 193 ---ALMELSGYIFEQFDRA-----AADPRDNLLGELATACAS-----GELDTLTAQVMMV 239 Query: 293 DLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVV 352 LF AG E+T+ L A+ +L P++ +V+ E A + Sbjct: 240 TLFAAGGESTAALLGSAVWILATRPDIQQQVRANPE------------------LLGAFI 281 Query: 353 HEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHF 412 E RY V +P + +L+ + D +F P F Sbjct: 282 EETLRYEPPF-RGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRA 340 Query: 413 LDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPV 472 +G + F G CVG ALA +E + L +L ++ D + + Sbjct: 341 GGKG--------HISFGKGAHFCVGAALARLEARIVLRLLLDRTSVIEAADVGGWLPSIL 392 Query: 473 VNGFASV 479 V + Sbjct: 393 VRRIERL 399 >6GII-A nrPDB Length = 479 Score = 139 bits (349), Expect = 4e-33, Method: Composition-based stats. Identities = 64/428 (14%), Positives = 128/428 (29%), Gaps = 75/428 (17%) Query: 51 SKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERAN--- 107 ++ P+F Y V+ Y+ +K+ D FS + + + Sbjct: 80 PAQFVRWAREQVPIF--YAPKLNYWVVTRYDTIKQIFRDP-VTFSPSNVLQSFAQPSAEV 136 Query: 108 ----RGFGIVFS-----NGKKWKEIRRFSLM---TLRNFGMGKRSIEDRVQEEARCLVEE 155 +G F+ + RR LM + + + + V+ ++ Sbjct: 137 RQVLERYGYAFNRTLVNEDEPMHLERRRVLMEPFASEHLAEHEPMVRELVRRAVNRFIDT 196 Query: 156 LRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQI 215 R A FL + + E ++ + I Sbjct: 197 GRADLVDQMIWEVPFTVAL------------------HFLGVDDDDREKMRRFA-----I 233 Query: 216 CNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEK 275 + + P + + V + E +++ + + D + +++ Sbjct: 234 AHTVNAFGRPSPEEQLAVAETVGQFWQFCGEVLEKMRRTADGPGW-------MRYSIRQQ 286 Query: 276 HNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNR 335 P T L + + A ETT AL LL+H V ++ + + Sbjct: 287 KLYPDVVTDSYLHSMMQAIIVAAHETTVFATTNALKTLLEHETVWREICADPSLI----- 341 Query: 336 SPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVL 395 A E RY + T +++ +P G IL+ + S Sbjct: 342 -------------PAAAEECLRYNGPV-AGWRRRTTREVEVEGVRLPVGANILMVVASAN 387 Query: 396 HDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQN 455 HD+ F +PE FD + + F G C+G L ME+ + + + + Sbjct: 388 HDSAHFDDPEFFDIGR--------SNASEHLNFGYGAHQCLGRNLGRMEMQIMIEELSRR 439 Query: 456 FNLKSLVD 463 L + Sbjct: 440 LPHMRLAE 447 >5DQN-A nrPDB Length = 426 Score = 135 bits (339), Expect = 6e-32, Method: Composition-based stats. Identities = 39/219 (17%), Positives = 78/219 (35%), Gaps = 37/219 (16%) Query: 253 ESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLL 312 E +N +D + + E + + + V L AG ETT ++ + ++ Sbjct: 212 EERAVNPTEDIVTKLI-----EADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITHGMIA 266 Query: 313 LLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTC 372 ++P+ ++E + E+ R+ + ++ Sbjct: 267 FAQNPDQWELYKKERP--------------------ETAADEIVRWATPV-SAFQRTALE 305 Query: 373 DIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSA-G 431 D++ I KG +++S S D + F +P F+ + + F G Sbjct: 306 DVELGGVQIKKGQRVVMSYRSANFDEEVFEDPHTFNI---------LRSPNPHVGFGGTG 356 Query: 432 KRICVGEALAGMELFLFLTSILQNFN-LKSLVDPKNLDT 469 C+G LA M + L +I N LK + P+ L + Sbjct: 357 AHYCIGANLARMTINLIFNAIADNMPDLKPIGAPERLKS 395 >1WIY-A nrPDB Length = 389 Score = 134 bits (338), Expect = 6e-32, Method: Composition-based stats. Identities = 57/287 (19%), Positives = 99/287 (34%), Gaps = 26/287 (9%) Query: 184 HKRFDYKDQQFLNLMEKLNENIKI---LSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 240 R +++ + E E + + + +++ P LK + + Sbjct: 105 GYREAMEEEAWAFFGEWRGEERDLDHEMLALSLRLLGRALFGKPLSPSLAEHALKALDRI 164 Query: 241 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 300 + + + + +D + H S E + AV L AG E Sbjct: 165 MAQTRSPLALLDLAAEARFRKDRGALYREAEALIVHPPLSHLPRERALSEAVTLLVAGHE 224 Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360 T ++ L ++ LLL P+ +V E E + E R Sbjct: 225 TVASALTWSFLLLSHRPDWQKRVAESEEAALAAF------------------QEALRLYP 266 Query: 361 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 420 L + + +P+GTT+++S FP E F P FL E G Sbjct: 267 PA-WILTRRLERPLLLGEDRLPQGTTLVLSPYVTQR--LYFPEGEAFQPERFLAERGT-- 321 Query: 421 KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNL 467 S + PF G+R+C+G A +E + L + + F L L P+ L Sbjct: 322 PSGRYFPFGLGQRLCLGRDFALLEGPIVLRAFFRRFRLDPLPFPRVL 368 >4PWV-A nrPDB Length = 446 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 65/421 (15%), Positives = 130/421 (30%), Gaps = 77/421 (18%) Query: 74 IVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRG-----FGIVFSNGKKWKEIRRFSL 128 V+ Y V AL ++ + L G + ++G + +R L Sbjct: 76 FWVVSRYADVM-ALYKDNKKLTSEKGNVLVTLLAGGDSAAGKMLAVTDGAMHRGLRNVLL 134 Query: 129 MTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCA---PCNVICSIIFHK 185 + ++++ V + R L A + F A P N I ++ Sbjct: 135 KSFSP-----QALKPIVDQI-RVNTTRLVVDAARRGECDFAADVAEQIPLNTISDLLG-- 186 Query: 186 RFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYIL 245 D++FL + K + + + I+ YF Sbjct: 187 -VPAADREFLLKLNKSALSSEDADQSATDAWLARNEILLYF------------------S 227 Query: 246 EKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTT 305 E V E + +D I M T E + L G ET+ + Sbjct: 228 ELVAERR----AKPTEDVISVLANSMV-----DGKPLTEEVIVLNCYSLILGGDETSRLS 278 Query: 306 LRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTS 365 + ++ ++P+ +++ ++ EV R+ Sbjct: 279 MIDSVQTFTQYPDQWELLRDGKVT------------------LESATEEVLRWATPAMHF 320 Query: 366 LPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYF 425 AVT D++ +I G + + S D + F +P FD + Sbjct: 321 GRRAVT-DMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAFDLNR---------SPNKH 370 Query: 426 MPFSAGKRICVGEALAGMELFLFLTSILQNFN--LKSLVDPKNLDTTPVVNGFASVPPFY 483 + F G C+G L E+ L ++ + + + +P+ + + + G + +P Sbjct: 371 ITFGYGPHFCLGAYLGRAEVHALLDAL-RTYTTGFEITGEPQRIHSN-FLTGLSRLPVRI 428 Query: 484 Q 484 Q Sbjct: 429 Q 429 >6DCD-A nrPDB Length = 424 Score = 132 bits (333), Expect = 3e-31, Method: Composition-based stats. Identities = 37/212 (17%), Positives = 70/212 (33%), Gaps = 27/212 (12%) Query: 245 LEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTST 304 L+ + + + + + + L + + S + + +A LF AG ETT+ Sbjct: 200 LQWLDDKFSAYIEDRRRQPRNDVLTALATATYPDGSTPEVIDVVRSATFLFAAGQETTAK 259 Query: 305 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPT 364 L A+ +L P++ +++E + + E R + Sbjct: 260 LLTAAMRVLGDRPDIQRRLRENRSLI------------------PNFIEESLRMDSPV-K 300 Query: 365 SLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKY 424 S I GT +++ + D + F +P F + Sbjct: 301 SDSRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDR--------PNVRE 352 Query: 425 FMPFSAGKRICVGEALAGMELFLFLTSILQNF 456 M F+ G C G LA +E + L IL Sbjct: 353 HMAFARGVHSCPGGPLARVEGRVSLERILDRM 384 >2UUQ-A nrPDB Length = 414 Score = 132 bits (332), Expect = 3e-31, Method: Composition-based stats. Identities = 57/371 (15%), Positives = 110/371 (29%), Gaps = 61/371 (16%) Query: 112 IVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILG 171 +V + E R+ + ++E V++ +E+LR T + Sbjct: 96 MVMQDPPVHTEFRKLVSRGFTPRQV--ETVEPTVRKFVVERLEKLRANGGGDI-VTELFK 152 Query: 172 CAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHN 231 P V+ + +D + W Q + + G Sbjct: 153 PLPSMVVAHYLG---VPEEDWTQFD--------------GWTQAIVAANAV----DGATT 191 Query: 232 KLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTA 291 L V M +Y ++ + D I + + + + Sbjct: 192 GALDAVGSMMAYFTGLIERRR----TEPADDAISHLVAAGVGADGDTAGTLS---ILAFT 244 Query: 292 VDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAV 351 + G +T + L ++ LL + P+ + ++ E + Sbjct: 245 FTMVTGGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEGIPD------------------A 286 Query: 352 VHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEF-PNPEMFDPH 410 V E+ R + L T D+ + IP G +L+ S D +++ P+ D Sbjct: 287 VEELLRLTSPVQ-GLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVT 345 Query: 411 HFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFN-LKSLVDPKNLDT 469 + + FS G C+G A A M+ + LT +L + Sbjct: 346 RC---------PRNILTFSHGAHHCLGAAAARMQCRVALTELLARCPDFEVAESRIVWSG 396 Query: 470 TPVVNGFASVP 480 V SVP Sbjct: 397 GSYVRRPLSVP 407 >5H1Z-A nrPDB Length = 407 Score = 131 bits (330), Expect = 6e-31, Method: Composition-based stats. Identities = 54/366 (14%), Positives = 112/366 (30%), Gaps = 64/366 (17%) Query: 118 KKWKEIRRFSLMTLRNFGM--GKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPC 175 K RR M +I R E L +P D + Sbjct: 97 PKHTGQRRTVAPAFTPSEMVRMSDNIRMRTAEVLDSL------EWNTPFDWVDTVSVELT 150 Query: 176 NVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLK 235 + +I+F F +++++ L +I+++ + +++ + L+ Sbjct: 151 TQMLAILFD--FPWEERRKLTFWSDWAGDIELVKNEELRL----------------ERLR 192 Query: 236 NVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLF 295 ++ Y + D I + + +E + L Sbjct: 193 HMYECGGYFQNLWN---AKIGKPPTPDLISMMI------HSDAMAEMDQMEFLGNLILLI 243 Query: 296 GAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEV 355 G +TT T+ L P+ AK++ + + V E+ Sbjct: 244 VGGNDTTRNTMSAVAYGLDLFPDQRAKLEADPSMI------------------PNTVQEI 285 Query: 356 QRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDE 415 R+ L + T D + I G + + S D F N + Sbjct: 286 IRWQTPLAH-MRRTATVDSELEGQQIKAGDKLALWYISANRDESVFENADRIIVDR---- 340 Query: 416 GGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSIL-QNFNLKSLVDPKNLDTTPVVN 474 ++ + F G CVG LA +++ + L + + + L +P+ + V+ Sbjct: 341 ----PNARRHLAFGHGIHRCVGARLAELQIAVLLEEMAKRRMRVNVLGEPERV-AACFVH 395 Query: 475 GFASVP 480 G+ +P Sbjct: 396 GYRKLP 401 >6G5O-A nrPDB Length = 399 Score = 131 bits (329), Expect = 7e-31, Method: Composition-based stats. Identities = 63/326 (19%), Positives = 110/326 (33%), Gaps = 48/326 (14%) Query: 170 LGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGT 229 L ++ + + L L + +L++P+ + S F Sbjct: 103 LTAQISEIVEETLLKGSVEVVTDFALRLQSRALT--LLLNTPFSESETWISWGTHVFRSE 160 Query: 230 HNKLLKNVAFMKS-YILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLE 288 L + A + YI E++ E NP D + L+ E E + T E ++ Sbjct: 161 GEALDGDKANILYHYIDEQIDRASE-----NPGDDMYSVLLNSEFE----GRKLTKEEVK 211 Query: 289 NTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYT 348 V F G +T + ++ L +HPE ++++E E T Sbjct: 212 GVMVLTFAGGRDTVINAVTNSIAYLAEHPEALERLRKEPE------------------IT 253 Query: 349 DAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFD 408 V E+ RY L T + VT D + + + I + S D F NP Sbjct: 254 GRAVEEMIRYFSPL-TQMGRVVTEDTHVCEHAVKADSRISLCWASANRDAAVFENPNEIV 312 Query: 409 PHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQN---FNLKSLVDP- 464 K + F C+G A L + L ++ Q F + + Sbjct: 313 LDR---------KVNPHVGFGFSHHNCLGATHARQILKILLQTLAQKVASFEILDYKENI 363 Query: 465 KNLDTTPVVNGFASVPPFYQLCFIPV 490 ++LD GF ++ Q+ F P+ Sbjct: 364 EDLDHFQRKVGFHNI----QIKFNPL 385 >3WEC-A nrPDB Length = 419 Score = 130 bits (327), Expect = 1e-30, Method: Composition-based stats. Identities = 68/450 (15%), Positives = 132/450 (29%), Gaps = 84/450 (18%) Query: 47 IKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDL--GEEFSGRGIFPLAE 104 D L P+ G ++ Y + + L G++F+ F Sbjct: 23 KADPYPVYARLRTEL-PIHRSALG---AWIVADYTSCDKVLRSRLFGKDFANSTFFDHLT 78 Query: 105 -------RANRGFGI-------VFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEAR 150 G GI + ++ + +R S++D V A Sbjct: 79 SMMGEDMPPFLGLGIDGDARPFMLTDPPEHTRLRGLVSDAFTRST--TTSMDDIVLSAAS 136 Query: 151 CLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSS 210 V L + + P V+ SI+ KD+ + Sbjct: 137 SAVRHLEHCTDAVSEVAEPF---PVEVLSSILG---IPDKDRGRFSE------------- 177 Query: 211 PWIQICNNFSPIIDYFPGT-HNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLM 269 W + I P ++ + Y + N P+ L+ Sbjct: 178 -WSNLVAGVLDINFAIPKEVADRRSAAIEESIDYF------RTLATSGNAPE-----GLV 225 Query: 270 KMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIER 329 + E + + +++ + T + + AG ETTS T+ L+ +H + +V+ + Sbjct: 226 RRLSEVSHGGDQLSVDEIAATCLLITVAGQETTSNTIGNMLITFSRHADQFEQVRANPQ- 284 Query: 330 VIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILI 389 + + V EV R+ D + I KG +++ Sbjct: 285 -----------------FIENAVAEVLRFEPPA-HEAGRIALEDCEVSGANITKGDAVMV 326 Query: 390 SLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFL 449 L S + + F + + + G C+G ALA L FL Sbjct: 327 LLASGNR--EAVERGDTF---------SVTRPDVSSLSYGRGIHHCLGSALANSMLQHFL 375 Query: 450 TSILQNFNLKSLVDPKNLDTTPVVNGFASV 479 + Q + + +P N + G ++ Sbjct: 376 RELSQRYRSIEVAEPINYKPGMGLRGPETL 405 >2IJ7-A nrPDB Length = 396 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 46/209 (22%), Positives = 74/209 (35%), Gaps = 29/209 (13%) Query: 275 KHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRN 334 K S + E V FGAG +T + L AL+ L++ P++ + E+ E + Sbjct: 211 KDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELI---- 266 Query: 335 RSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSV 394 A V E+ R LP T DI+ + L+ KG +L+ L Sbjct: 267 --------------PAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGA 312 Query: 395 LHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQ 454 D + FPNP + + F G+ C G AL + + ++L+ Sbjct: 313 NFDPEHFPNPGSIELDR--------PNPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLK 364 Query: 455 NFNLKSLVDPKN---LDTTPVVNGFASVP 480 L P + T +P Sbjct: 365 KMPGVDLAVPIDQLVWRTRFQRRIPERLP 393 >3IVY-A nrPDB Length = 433 Score = 129 bits (324), Expect = 3e-30, Method: Composition-based stats. Identities = 41/236 (17%), Positives = 83/236 (35%), Gaps = 41/236 (17%) Query: 236 NVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLF 295 + A + Y ++ +E NP D I L+ + + + + V L Sbjct: 216 SSAELIGYAMKMAEEK-----AKNPADDIVTQLI----QADIDGEKLSDDEFGFFVVMLA 266 Query: 296 GAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEV 355 AG ETT ++ ++ +HP+ + +++ + E+ Sbjct: 267 VAGNETTRNSITQGMMAFAEHPDQWE-LYKKVRP-------------------ETAADEI 306 Query: 356 QRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDE 415 R+ + T+ D + I KG +++ S D + F +P F+ Sbjct: 307 VRWATPV-TAFQRTALRDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNI------ 359 Query: 416 GGNFKKSKYFMPFSA-GKRICVGEALAGMELFLFLTSILQNFN-LKSLVDPKNLDT 469 + + F G C+G LA M + L ++ + LK + P+ L + Sbjct: 360 ---LRNPNPHVGFGGTGAHYCIGANLARMTINLIFNAVADHMPDLKPISAPERLRS 412 >2WIY-A nrPDB Length = 394 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 38/244 (15%), Positives = 73/244 (29%), Gaps = 32/244 (13%) Query: 237 VAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFG 296 A Y+ +V E E +N D L E T T + + Sbjct: 179 AAVAFGYLSARVAEMLEDKRVNPGDGLADSLLDAARA------GEITESEAIATILVFYA 232 Query: 297 AGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQ 356 G + + L + PEV + + A+++E+ Sbjct: 233 VGHMAIGYLIASGIELFARRPEVFTAFRNDESA------------------RAAIINEMV 274 Query: 357 RYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEG 416 R S T D++ LI G+ I + + D + F +P++FD Sbjct: 275 RMDPP-QLSFLRFPTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHTR----- 328 Query: 417 GNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGF 476 + + F G C G+ ++ E + + + L + + + Sbjct: 329 --PPAASRNLSFGLGPHSCAGQIISRAEATTVFAVLAERYERIELAEEPTVAHNDFARRY 386 Query: 477 ASVP 480 +P Sbjct: 387 RKLP 390 >3OFT-A nrPDB Length = 396 Score = 122 bits (306), Expect = 3e-28, Method: Composition-based stats. Identities = 74/411 (18%), Positives = 124/411 (30%), Gaps = 76/411 (18%) Query: 62 GPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFS----NG 117 G V++ G + + V+E D E S LA G + F +G Sbjct: 38 GLVWSTANGGH--WIAARGDVVRELWGD-AERLS---SQCLAVTPGLGKVMQFIPLQQDG 91 Query: 118 KKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILG-CAPCN 176 + K R + L ++E +VQ AR L+E LR CD P N Sbjct: 92 AEHKAFRTPVMKGLA--SRFVVALEPKVQAVARKLMESLR--PRGSCDFVSDFAEILPLN 147 Query: 177 VICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKN 236 + FL L++ E+ L +Q+ P + + Sbjct: 148 I----------------FLTLIDVPLEDRPRLRQLGVQLTR---------PDGSMTVEQL 182 Query: 237 VAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFG 296 Y+ +++ D ++ E +T++ +L Sbjct: 183 KQAADDYLWPFIEKRMAQ--------PGDDLFSRILSEPVG-GRPWTVDEARRMCRNLLF 233 Query: 297 AGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQ 356 G +T + + L L +HPE ++E + + A E+ Sbjct: 234 GGLDTVAAMIGMVALHLARHPEDQRLLRERPDLI------------------PAAADELM 275 Query: 357 RYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEG 416 R + ++ D+ I KG + + D F PE L Sbjct: 276 RRYPTV--AVSRNAVADVDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDRGL--- 330 Query: 417 GNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNL 467 G CVG LA ME+ +FL L +L K + Sbjct: 331 ----APIRHTTMGVGAHRCVGAGLARMEVIVFLREWLGGMPEFALAPDKAV 377 >6G71-A nrPDB Length = 405 Score = 121 bits (304), Expect = 6e-28, Method: Composition-based stats. Identities = 71/436 (16%), Positives = 134/436 (30%), Gaps = 66/436 (15%) Query: 48 KDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERAN 107 ++ L PV + + ++ Y V A +D FS L RA Sbjct: 21 QNPFPIFERLRS-ESPVAWVPEAGRY--LITSYSGVLAADVDQ-TTFSANEKKSLMLRA- 75 Query: 108 RGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPT 167 G ++ + + RR +L+ G K+ + + E A ++ S D Sbjct: 76 MGHSMLRKDDPDHQVERRAWQPSLKP-GTVKKVWKQKFAENADRYLDAY-IDAGSGSDFM 133 Query: 168 FILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFP 227 + L + + W Q + + P Sbjct: 134 QGFAA----------------PFVAENLRALIGFENASEADLQRWSQTLIDGAGNYPDDP 177 Query: 228 GTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESL 287 K ++ + + + E ++ H P D + +L+ + + +ES+ Sbjct: 178 DVWAKAKQSSDEIDAALEEMIQWH-----SGRPGDSLLSYLL------RSADYQMPLESI 226 Query: 288 ENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPY 347 + G G L + L LL + V + + Sbjct: 227 RSNIKMTIGGGLNEPRDVLGVSTLALLSSSKQLELVLRDPK------------------L 268 Query: 348 TDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMF 407 AV E R++ + +P D + Y IP+G + + + S D + +P+ F Sbjct: 269 WGAVFEESIRWVAPI-GMVPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWSDPDRF 327 Query: 408 DPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGME-LFLFLTSILQNFNLKSLVDPKN 466 D S+ + F G +C+G A + + L ++ L DP Sbjct: 328 DIER---------GSEAHLAFGKGVHVCLGAWAARSQVADVGLPALFSRLKGLRL-DPNQ 377 Query: 467 LDTTP--VVNGFASVP 480 T V G S+P Sbjct: 378 EATHGGWVFRGPLSLP 393 >2IAG-A nrPDB Length = 482 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 90/493 (18%), Positives = 172/493 (34%), Gaps = 52/493 (10%) Query: 22 QSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYE 81 ++ G+ P +P +G L G KD + LT + + +G +FT+ G + + VL Sbjct: 1 RTRRPGEPPLDLGSIPWLGYALDFG-KDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPH 59 Query: 82 AVKEALI--DLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKR 139 + + +F IF L ER +S + ++ + R Sbjct: 60 SYDAVVWEPRTRLDFHAYAIF-LMERIFDVQLPHYSPSDEKARMK---------LTLLHR 109 Query: 140 SIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLME 199 ++ + L L +G S F R Y + + Sbjct: 110 ELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDF----SYSFLLRAGYLTLYGIEALP 165 Query: 200 KLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLL----KNVAFMKSYILEKVKEHQESM 255 + +E+ + + F + P L K+ L K+ Sbjct: 166 RTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLA 225 Query: 256 DMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLK 315 + +++ +L+ +E+ + E V A + LL LLK Sbjct: 226 RRAHRSKWLESYLLHLEEMG------VSEEMQARALVLQLWATQGNMGPAAFWLLLFLLK 279 Query: 316 HPEVTAKVQEEIERVIGRNRSPCMQD-------RSHMPYTDAVVHEVQRYIDLLPTSLPH 368 +PE A V+ E+E ++ + P Q P D+V+ E R + Sbjct: 280 NPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLT--AAPFITR 337 Query: 369 AVTCDIKF-----RNYLIPKGTTILISL-TSVLHDNKEFPNPEMFDPHHFLDEGGNFKK- 421 V D+ R + + +G +L+ S D + + +PE+F + FL+ G+ KK Sbjct: 338 EVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKD 397 Query: 422 --------SKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVV 473 Y MP+ AG C+G + A + F+ +L + +L+ + + + Sbjct: 398 FYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLS 457 Query: 474 N-GFASVPPFYQL 485 GF + P + + Sbjct: 458 RYGFGLMQPEHDV 470 >3BUJ-A nrPDB Length = 397 Score = 119 bits (297), Expect = 4e-27, Method: Composition-based stats. Identities = 62/433 (14%), Positives = 128/433 (29%), Gaps = 75/433 (17%) Query: 67 LYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANR--------GFGIVFSNGK 118 ++ G + + + V+ L D E F+ GI G I+F + Sbjct: 28 VHRGAHRVWYVSRFADVRAVLGD--ERFARTGIRRFWTDLVGPGLLAEIVGDIILFQDEP 85 Query: 119 KWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVI 178 +R + R +E + L L +V+ Sbjct: 86 DHGRLRGVVGPAFSPSAL--RRLEPVIAGTVDDL-------------LRPALARGAMDVV 130 Query: 179 CSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVA 238 + + + L L+ + + + G + ++ Sbjct: 131 DELA----YPLALRAVLGLLGLPAADWGAVGRWSRDVGRTLD------RGASAEDMRRGH 180 Query: 239 FMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAG 298 + + V+ +D + L + + + +T V G Sbjct: 181 AAIAEFADYVERALARRRREGGEDLLALMLDA------HDRGLMSRNEIVSTVVTFIFTG 234 Query: 299 TETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRY 358 ET ++ + A+L LL HP+ ++ + V E RY Sbjct: 235 HETVASQVGNAVLSLLAHPDQLDLLRRRPD------------------LLAQAVEECLRY 276 Query: 359 IDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGN 418 + ++ + D++ R + + +++ + D + + P+ FD Sbjct: 277 DPSVQSNT-RQLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDFDIER------- 328 Query: 419 FKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQN--FNLKSLVDPKNLDTTPVVNGF 476 M F AG R C+G LA +L + ++ + L D + G Sbjct: 329 --DPVPSMSFGAGMRYCLGSYLARTQLRAAVAALARLPGLRLGCASDALAYQPRTMFRGL 386 Query: 477 ASVPPFYQLCFIP 489 AS+P + F P Sbjct: 387 ASLP----IAFTP 395 >3B98-A nrPDB Length = 475 Score = 119 bits (297), Expect = 4e-27, Method: Composition-based stats. Identities = 92/509 (18%), Positives = 173/509 (33%), Gaps = 78/509 (15%) Query: 19 LWRQSSG--------RGKLPPGPTP-LPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYF 69 + +++S R PP +P +G+ L+ G KD +K LT + + +G +FT+ Sbjct: 1 MAKKTSSVLYGRRTRRRNEPPLDKGMIPWLGHALEFG-KDAAKFLTRMKEKHGDIFTVRA 59 Query: 70 GLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLM 129 I VL L D+ L +R I+ S+ + ++ R Sbjct: 60 AGLYITVLLDSNCYDAVLSDVASLDQTSYAQVLMKRIFN--MILPSHNPESEKKRAEMHF 117 Query: 130 TLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDY 189 + S+++ ++ E KT D F N+ S++F Sbjct: 118 QGASLTQLSNSMQNNLR-LLMTPSEMGLKTSEWKKDGLF-------NLCYSLLFKT---- 165 Query: 190 KDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLL-----KNVAFMKSYI 244 +L + N N S+ QI F P + + + + + Sbjct: 166 ---GYLTVFGAENNN----SAALTQIYEEFRRFDKLLPKLARTTVNKEEKQIASAAREKL 218 Query: 245 LEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFG----AGTE 300 + + Q ++ ++ +++ E + + + L+ AG Sbjct: 219 WKWLTPSGLDRKPRE-QSWLGSYVKQLQDEGIDAEMQR-----RAMLLQLWVTQGNAGP- 271 Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360 + + LL HPE V+EEI+ G + + + P D+V+ E R Sbjct: 272 ----AAFWVMGYLLTHPEALRAVREEIQ---GGKHLRLEERQKNTPVFDSVLWETLRLT- 323 Query: 361 LLPTSLPHAVTCDIKF-----RNYLIPKGTTILISL-TSVLHDNKEFPNPEMFDPHHFLD 414 + VT D K + Y + +G + + S D + PEMF FL+ Sbjct: 324 -AAALITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLN 382 Query: 415 EGGNFKK---------SKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPK 465 KK +P+ +C G A + + +IL F+++ Sbjct: 383 ADRTEKKDFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNA 442 Query: 466 NLDTT-PVVNGFASVPP------FYQLCF 487 + P GF + P Y++ F Sbjct: 443 TVPLVDPSRYGFGILQPAGDLEIRYRIRF 471 >6HQD-A nrPDB Length = 420 Score = 118 bits (296), Expect = 5e-27, Method: Composition-based stats. Identities = 58/451 (12%), Positives = 134/451 (29%), Gaps = 79/451 (17%) Query: 45 IGIKDISKSLTNLSKV----------YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEF 94 + L + YGP +++ + + ++ + Sbjct: 29 FERDGLHPYFERLRREDPVHYCKASEYGPYWSITKFSDIVAIDTNHKVFS------SDHT 82 Query: 95 SGRGIFPLAERANRGFGIVFSN-----GKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEA 149 +G + GI N K R + + + E ++E Sbjct: 83 NGSFVLDDTTLNAVDGGIYLPNFLGMDPPKHDVHRMVVSPIVAPQNLLR--FEATIRERT 140 Query: 150 RCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILS 209 + ++ EL + + + + F + D++ L Sbjct: 141 KRVLSELPIGEEFNWVDRVSIELTTMMLATLLDF----PFDDRRKL-------------- 182 Query: 210 SPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLM 269 + W I + + + +Y E Q M D I Sbjct: 183 TRWSDIITTRPGYGLV--DSWEQRESELMECLAYFQRLYAERQA---MPPKPDLISML-- 235 Query: 270 KMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIER 329 + + T T L G +TT +++ + + +P+ KV+ Sbjct: 236 ----AHSPEMQDLTPTDFLGTLALLIVGGNDTTRSSMSGSAMACHLYPQEFDKVR----- 286 Query: 330 VIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILI 389 ++ +V+ EV R+ + + D++FR I KG +++ Sbjct: 287 -------------NNRALLASVIPEVVRWQTPIAH-MRRTALEDVEFRGKQIRKGDKVVM 332 Query: 390 SLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFL 449 S D++ P F ++++ + F G C+G LA ++L + Sbjct: 333 WYLSGNRDDEVIDRPMDFIADR--------PRARHHLSFGFGIHRCLGNRLAELQLKILW 384 Query: 450 TSILQNFNLKSLVDPKNLDTTPVVNGFASVP 480 + + ++ + + +V+G+ +P Sbjct: 385 EEMCERYSRIEVCGEPVRVPSNLVHGYIDIP 415 >4FB2-A nrPDB Length = 398 Score = 118 bits (295), Expect = 6e-27, Method: Composition-based stats. Identities = 63/408 (15%), Positives = 117/408 (28%), Gaps = 69/408 (16%) Query: 75 VVLHGYEAVKEALIDLGEEFSGRGI-FPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRN 133 V+ GY+ + +A+I + FS +G+ FP E + + K+ R+ Sbjct: 47 WVVAGYKEI-QAVIQNTKAFSNKGVTFPRYETGEFELMMAGQDDPVHKKYRQLVAKPFSP 105 Query: 134 FGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQ 193 E E+LR++ D LG D Sbjct: 106 -------------EATDLFTEQLRQSTNDLIDARIELG-----------------EGDAA 135 Query: 194 FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQE 253 E IL + + + + TH + + A + + ++ + Sbjct: 136 TWLANEIPARLTAILLGLPPEDGDTYRRWVWAI--THVENPEEGAEIFAELVAHARTLIA 193 Query: 254 SMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLL 313 N D + +M + + L L G + T+ L L Sbjct: 194 ERRTNPGNDIMSRVIMSKI-----DGESLSEDDLIGFFTILLLGGIDNTARFLSSVFWRL 248 Query: 314 LKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCD 373 E+ ++ E + V E+ R+ P + VT + Sbjct: 249 AWDIELRRRLIAHPELI------------------PNAVDELLRFY--GPAMVGRLVTQE 288 Query: 374 IKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKR 433 + + + G T ++ D F +P+ + G Sbjct: 289 VTVGDITMKPGQTAMLWFPIASRDRSAFDSPDNIVIER---------TPNRHLSLGHGIH 339 Query: 434 ICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTP-VVNGFASVP 480 C+G L +E + +T L+ SL K + V G VP Sbjct: 340 RCLGAHLIRVEARVAITEFLKRIPEFSLDPNKECEWLMGQVAGMLHVP 387 >6BLD-A nrPDB Length = 419 Score = 117 bits (294), Expect = 9e-27, Method: Composition-based stats. Identities = 69/412 (16%), Positives = 121/412 (29%), Gaps = 62/412 (15%) Query: 73 PIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLR 132 IV + V L G F AE + + + ++R+ Sbjct: 69 DIVAVSRTNEV--FLSGNGVLFENVP----AELLEASQSFLAMDPPRHTKLRKLVSAAFT 122 Query: 133 NFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC-APCNVICSIIFHKRFDYKD 191 + R IED ++ A+ +V+ELR D P + ++ D Sbjct: 123 PRQV--RRIEDSIKINAKGIVDELRMAGGG-VDFVEHCAKELPIRTLSDMVG---IPEAD 176 Query: 192 QQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEH 251 ++ + ++S + N P+ F L +V Sbjct: 177 RE-----RVAHAADALVSWADPRYLNGREPLAVLFEN-------------QMYLHQVAAS 218 Query: 252 QESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALL 311 + + P D + L+ E + V L AG +TT T+ + L Sbjct: 219 LAAERRDRPGDDLFSALVNAEV----DGDRLADADVAAFFVLLAVAGNDTTRQTISHGLK 274 Query: 312 LLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVT 371 L P A + + + IG V E+ R+ + + Sbjct: 275 ALTDFPSQKAWLLADFDTRIGT-----------------AVEELVRWATPV-MTFRRTAA 316 Query: 372 CDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAG 431 D + LI G +++ S D F +PE D + F Sbjct: 317 ADFELGGQLIRAGEKVVMFYASGNWDEDAFCHPERLDLSRSPNPHVGFGGGGVH------ 370 Query: 432 KRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFY 483 C+G LA +L +L DP + V+ S+P + Sbjct: 371 --FCLGAHLARAQLRAIFGELLVQLPDIQAGDPVYVPGN-FVHAIRSMPCTF 419 >2QBO-A nrPDB Length = 421 Score = 116 bits (291), Expect = 2e-26, Method: Composition-based stats. Identities = 71/419 (16%), Positives = 131/419 (31%), Gaps = 71/419 (16%) Query: 64 VFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEI 123 V+T G + + ++EA D S P F + + Sbjct: 55 VWTRCNGGH--WIATRGQLIREAYEDYRHFSSECPFIPREAGEAYDFIPTSMDPPE---Q 109 Query: 124 RRFSLMTLRNFGM-GKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSII 182 R+F + + GM +E+R+QE A L+E LR C+ Sbjct: 110 RQFRALANQVVGMPVVDKLENRIQELACSLIESLRPQGQ-----------------CNFT 152 Query: 183 FHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKS 242 + + F+ L E+I L Q+ P + + Sbjct: 153 EDYAEPFPIRIFMLLAGLPEEDIPHLKYLTDQMTR---------PDGSMTFAEAKEALYD 203 Query: 243 YILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETT 302 Y++ +++ ++ + + + T + + L G +T Sbjct: 204 YLIPIIEQRRQKPGTDA---------ISIVANGQVNGRPITSDEAKRMCGLLLVVGLDTV 254 Query: 303 STTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLL 362 L +++ L K PE ++ E ER+ A E+ R L+ Sbjct: 255 VNFLSFSMEFLAKSPEHRQELIERPERI------------------PAACEELLRRFSLV 296 Query: 363 PTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS 422 +T D +F + KG IL+ D +E P D + Sbjct: 297 ADG--RILTSDYEFHGVQLKKGDQILLPQMLSGLDERENACPMHVDFSR---------QK 345 Query: 423 KYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTP-VVNGFASVP 480 F G +C+G+ LA E+ + L L S+ + +V+G ++P Sbjct: 346 VSHTTFGHGSHLCLGQHLARREIIVTLKEWLTRIPDFSIAPGAQIQHKSGIVSGVQALP 404 >5D3U-A nrPDB Length = 427 Score = 116 bits (290), Expect = 3e-26, Method: Composition-based stats. Identities = 61/369 (16%), Positives = 107/369 (28%), Gaps = 53/369 (14%) Query: 112 IVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILG 171 +++++ +RR + + +Q+ A LV + A+ D L Sbjct: 108 VMYTDPPLHDALRRSVRAGFTR--AAHQHYDQVLQKVAHDLVASIPA-GATEIDAVPALA 164 Query: 172 CAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHN 231 F +D FL + ++N + S P Q I++ H Sbjct: 165 AELPVRSAVHAFG--VPEEDLGFL--IPRVNTIMTYFSGPKDQPVTQ-EIILEKLTDLHT 219 Query: 232 KLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTA 291 + + M+ +L D + L + E T+ L Sbjct: 220 YASELLQGMRGKVLP---------------DTVIARLAAAQDGLTETTPEQTVHQLALVF 264 Query: 292 VDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAV 351 + LF TT +L L ++P + + V D Sbjct: 265 IALFAP---TTPGSLSSGTLAFARNPRQVERFLADQACV------------------DNT 303 Query: 352 VHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHH 411 +EV RY + D++ I G T+ + L S D F P FD Sbjct: 304 ANEVLRYNASNQFTW-RVAAKDVEMGGVRIEAGQTLALFLGSANRDANMFERPNDFDLDR 362 Query: 412 FLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTP 471 S + F G C+ L ++L F ++L F + Sbjct: 363 --------PNSARHLSFGQGVHACLAAQLISLQLKWFYVALLNRFPGIRTAGEPIWNENL 414 Query: 472 VVNGFASVP 480 S+P Sbjct: 415 EFRSLRSLP 423 >5OMS-A nrPDB Length = 409 Score = 115 bits (288), Expect = 4e-26, Method: Composition-based stats. Identities = 62/392 (15%), Positives = 115/392 (29%), Gaps = 52/392 (13%) Query: 70 GLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFG---IVFSNGKKWKEIRRF 126 V + G A + S + R FG I+ NG ++R Sbjct: 37 APLAFVPVLGSYVASTAEVCREVATSPDFEAVITPAGGRTFGHPAIIGVNGDIHADLRSM 96 Query: 127 SLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKR 186 L+ + R I+D V+ AR +E D L C + Sbjct: 97 VEPALQPAEV-DRWIDDLVRPIARRYLERFEN------DGHAELVAQYCEPVSVRSLGDL 149 Query: 187 FDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILE 246 ++ L E + + ++ + F+ P + + A +++ + Sbjct: 150 LGLQEVDSDKLREWFAKLNRSFTNAAVDENGEFAN-----PEGFAEGDQAKAEIRAVVDP 204 Query: 247 KVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTA-VDLFGAGTETTSTT 305 + + E D D + + E + T V L GA E Sbjct: 205 LIDKWIEHPD--------DSAISHWLHDGMPPGQTRDREYIYPTIYVYLLGAMQEPGHGM 256 Query: 306 LRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTS 365 L+ L PE +V ++ + E R+ + ++ Sbjct: 257 -ASTLVGLFSRPEQLEEVVDDP------------------TLIPRAIAEGLRWTSPIWSA 297 Query: 366 LPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYF 425 T + +P GT +++S S HD ++ P +D H Sbjct: 298 TARISTKPVTIAGVDLPAGTPVMLSYGSANHDTGKYEAPSQYDLHR---------PPLPH 348 Query: 426 MPFSAGKRICVGEALAGMELFLFLTSILQNFN 457 + F AG C G A + + L + + Sbjct: 349 LAFGAGNHACAGIYFANHVMRIALEELFEAIP 380 >6FYJ-A nrPDB Length = 421 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 72/426 (16%), Positives = 140/426 (32%), Gaps = 63/426 (14%) Query: 63 PVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFP--LAERANRGFGIVFSNGKKW 120 +F K + + G EA E D E+F + P + + G+ +G+ Sbjct: 39 DIFETRLLGKKAICMGGKEAA-EIFYDT-EKFKRKDAAPNRVVQTLFGKNGVQALDGQTH 96 Query: 121 KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS 180 K R+ M++ M +E + E+ K D IL ++C Sbjct: 97 K-HRKEMFMSI----MSPDELEKLTDITKKQW--EIAVDKWEQMD-KVILYEEAKEIMCR 148 Query: 181 IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM 240 N +++L +N+ + + G + L ++ Sbjct: 149 TACQW---AGVPVQENEVKRLTKNLGAMFESAAAV------------GLKHWLGRHARNY 193 Query: 241 KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE 300 + +E++ + +N P++ + N T + A Sbjct: 194 EEIWIEELIDRVRDGKVNPPENTTLHKFSWYRDLEGNLLDTETAAVEVINILRPIVA--- 250 Query: 301 TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID 360 + + + L L +PE K++ Y+ V EV+R+ Sbjct: 251 -IAIFINFIALALHHYPEEKEKLKS-----------------GDKKYSQMFVQEVRRFYP 292 Query: 361 LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK 420 P + V D ++ Y +GT L+ L HD + + NP++F P F G+ Sbjct: 293 FFPFVVA-LVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDRFAKWEGS-- 349 Query: 421 KSKYFMPFSAGK----RICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGF 476 F+P G C GE + + + L + + + V ++L + Sbjct: 350 -PFSFIPQGGGDYFMGHRCAGEWVTIEVMKVSLDYLTNRMDYE--VPDQDLSFSM----- 401 Query: 477 ASVPPF 482 AS+P Sbjct: 402 ASMPSI 407 >5KYO-A nrPDB Length = 430 Score = 109 bits (273), Expect = 3e-24, Method: Composition-based stats. Identities = 64/414 (15%), Positives = 123/414 (29%), Gaps = 71/414 (17%) Query: 64 VFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIV--FSNGKKWK 121 ++T + G V + + + D E FS + E A + ++ + + + Sbjct: 75 MWTPHNGGH--WVALRSDLAETVMSDF-ERFSNHTVLVPKETAGEAYRLIPLSLDPPEHR 131 Query: 122 EIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSI 181 R L + R IE V + A L+E R CN Sbjct: 132 PFRSLLNENLGPKPL--RPIEQVVTDLAVSLIEGFRPKG-------------RCNFTHE- 175 Query: 182 IFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMK 241 F ++ + F+ +++ E++ L Q P L + Sbjct: 176 -FAEQLP--VRIFMRIVDLPVEDLPKLKHLADQYTR---------PDGSIPLDDVTKQFR 223 Query: 242 SYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTET 301 Y+ ++ + + +D I + T EN + + G +T Sbjct: 224 EYLRPVIEARR----IKPGEDMISRMINGEVG-----GRPLTDIEAENICIQVLVGGLDT 274 Query: 302 TSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDL 361 L + L K + + + + D + E R + Sbjct: 275 VVNMLGFTFSHLAKDHALRRAIAADPSLI------------------DDALLEFFRRFPV 316 Query: 362 LPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKK 421 + ++ V D +F L+ G ++ V D+ +P F K Sbjct: 317 VSSA--REVLRDQEFEGVLLKAGDMVMAPTVVVAMDDARNEDPLEFRLGR---------K 365 Query: 422 SKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNG 475 ++ F G C G LA ME+ + L + D L + + G Sbjct: 366 ARQHSTFGKGSHTCPGAHLARMEMKVVLREWFARIPEFRIEDDAPLRYSNGIVG 419 >5YHJ-A nrPDB Length = 413 Score = 109 bits (271), Expect = 4e-24, Method: Composition-based stats. Identities = 78/412 (18%), Positives = 141/412 (34%), Gaps = 66/412 (16%) Query: 64 VFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFP--LAERANRGFGIVFSNGKKWK 121 +F + ++ L G EA E D + F+ + P L + G+ +G + Sbjct: 36 IFESRLLGERVICLGGEEAA-EVFYDANK-FTRQDAAPKRLLKTLFGEGGVQTLDGSEH- 92 Query: 122 EIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSI 181 R+ M+L M K +I+ ++ R + R I +C Sbjct: 93 THRKQMFMSL----MTKENIDRLLRLTYREWNQIER--MGEEIVLYDIAQEVLMKAVCEW 146 Query: 182 IFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMK 241 + + M L E+ L ++Q + ++ A + Sbjct: 147 SGVPLAKEEVGKRTEEMRLLFESGTSLGPTYLQ----------------GRKARSSAEV- 189 Query: 242 SYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTET 301 +I + VKE + + + N + F ++ E E + V T Sbjct: 190 -WIRQMVKEVRSNRLLPNEHTALYEF-----SWHRDESGELLPEEVVAVEVLNILRPTVA 243 Query: 302 TSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDL 361 S + + +L L + P+V +V +R + T+ V EV+R+ Sbjct: 244 ISVYVLFTVLALHQFPDVKEQV-----------------ERGEVSKTE-FVQEVRRFYPF 285 Query: 362 LPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKK 421 P + T D ++ Y P+GT L+ L HD + P+ FDP F D + Sbjct: 286 FPVAAARVKT-DFEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSRFKDWKES--- 341 Query: 422 SKYFMPFSAGK----RICVGEALAGMELFLFLTSILQNF--NLKSLVDPKNL 467 F+P G C GE + L +++ F V P++L Sbjct: 342 PFNFIPQGGGDVDFGHRCAGEHVTI----AILAQVIELFTKEYAYTVPPQDL 389 >5M0P-A nrPDB Length = 428 Score = 101 bits (252), Expect = 7e-22, Method: Composition-based stats. Identities = 61/417 (14%), Positives = 123/417 (29%), Gaps = 57/417 (13%) Query: 64 VFTLY-FGLKPIVVLHGYEAVKEALIDLGEEFSGRG---IFPLAERANRGFGIVFSNGKK 119 VF G KP VV+ G E + + R + I +GKK Sbjct: 41 VFQTKALGGKPFVVVTGKEGAEMF---YNNDVVQREGMLPKRIVNTLAGKGAIHTVDGKK 97 Query: 120 WKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVIC 179 + + + + + R L L + + +++ Sbjct: 98 HVDRKALFMSLMTEGNL----------NYVRELTRTLWHANTQRMESMDEVNIYRESIVL 147 Query: 180 SIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAF 239 R+ Q +E++ ++ I+ + + F + Sbjct: 148 LTKVGTRW-AGVQAPPEDIERIATDMDIMIDSFRALGGAFKGY--------KASKEARRR 198 Query: 240 MKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGT 299 ++ ++ E++ E ++ + F + + S L NT L Sbjct: 199 VEDWLEEQIIETRKGNIHPPEGTALYEFAHWEDYLGNPMDSRTCAIDLMNTFRPLIA--- 255 Query: 300 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYI 359 + + + L + ++P K++ E + Y EV+RY Sbjct: 256 --INRFVSFGLHAMNENPITREKIKSEPD------------------YAYKFAQEVRRYY 295 Query: 360 DLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNF 419 +P LP DI F+ IP G + + + HD + +P F P F G+ Sbjct: 296 PFVPF-LPGKAKVDIDFQGVTIPAGVGLALDVYGTTHDESLWDDPNEFRPERFETWDGS- 353 Query: 420 KKSKYFMPFSAGK----RICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPV 472 +P G C GE + + + + + +D + Sbjct: 354 --PFDLIPQGGGDYWTNHRCAGEWITVIIMEETMKYFAEKITYDVPEQDLEVDLNSI 408 >2ZQJ-A nrPDB Length = 417 Score = 100 bits (248), Expect = 2e-21, Method: Composition-based stats. Identities = 69/458 (15%), Positives = 140/458 (30%), Gaps = 67/458 (14%) Query: 39 IGNILQIGIKDISKSLTNLSKVY-GPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGR 97 + N L + + + N ++ Y +F K + + G EA K D + F + Sbjct: 11 LDNSLTLLKEG-YLFIKNRTERYNSDLFQARLLGKNFICMTGAEAAK-VFYDT-DRFQRQ 67 Query: 98 GIFP-LAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEE-ARCLVEE 155 P +++ G + R+ ++L + R+ E Sbjct: 68 NALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL-----MTPPHQKRLAELMTEEWKAA 122 Query: 156 LRK-TKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQ 214 + + KA C V C + +K + +I Sbjct: 123 VTRWEKADEVVLFEEAKEILCRVACYWAG--------------VPLKETEVKERADDFID 168 Query: 215 ICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKE 274 + + F + + + +I +++ + + + +++ Sbjct: 169 MVDAFGAVGPRHWKGRRARPRA----EEWIEVMIEDARAGLLKTTSGTALHEMAFHTQED 224 Query: 275 KHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRN 334 S L N + S L ++ L L +HP+ ++ G + Sbjct: 225 GSQLDSRMAAIELINVLRPIVA-----ISYFLVFSALALHEHPKYKEWLRS------GNS 273 Query: 335 RSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSV 394 R + V EV+RY P L V D + N KGT++L+ L Sbjct: 274 RE-----------REMFVQEVRRYYPFGPF-LGALVKKDFVWNNCEFKKGTSVLLDLYGT 321 Query: 395 LHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGK----RICVGEALAGMELFLFLT 450 HD + + +P+ F P F + N +P G C GE + + L Sbjct: 322 NHDPRLWDHPDEFRPERFAEREENL---FDMIPQGGGHAEKGHRCPGEGITIEVMKASLD 378 Query: 451 SILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFI 488 ++ ++ + A +P + F+ Sbjct: 379 FLVHQIEY-------DVPEQSLHYSLARMPSLPESGFV 409 >3NV6-A nrPDB Length = 452 Score = 98.6 bits (244), Expect = 5e-21, Method: Composition-based stats. Identities = 69/421 (16%), Positives = 135/421 (32%), Gaps = 69/421 (16%) Query: 64 VFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGI-VFSNGKKWKE 122 ++T + G + + VKE D FS IF E + + + + Sbjct: 90 IWTPFTGGH--WIATNGDTVKEVYSDP-TRFSSEVIFLPKEAGEKYQMVPTKMDPPEHTP 146 Query: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSII 182 R+ L + R +ED+V+E A L++ C Sbjct: 147 YRKALDKGLNLAKI--RKVEDKVREVASSLIDSFAARGE-----------------CDFA 187 Query: 183 FHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKS 242 + F+ L + E+I +LS Q+ T ++ ++ + Sbjct: 188 AEYAELFPVHVFMALADLPLEDIPVLSEYARQMTRPEG-------NTPEEMATDLEAGNN 240 Query: 243 YILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETT 302 V + + D L+ + + + L G +T Sbjct: 241 GFYAYVDPIIRARVGGDGDD-----LITLMVNSEINGERIAHDKAQGLISLLLLGGLDTV 295 Query: 303 STTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLL 362 L + ++ L +HPE+ A+++ + +++ E+ R ++ Sbjct: 296 VNFLSFFMIHLARHPELVAELRSDPLKLMRGA------------------EEMFRRFPVV 337 Query: 363 PTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS 422 + V D +++ + +G IL+ D+ P P D +S Sbjct: 338 SEA--RMVAKDQEYKGVFLKRGDMILLPTALHGLDDAANPEPWKLDFSR---------RS 386 Query: 423 KYFMPFSAGKRICVGEALAGMELFLFLTSILQN---FNLKSLVDPKNLDTTPVVNGFASV 479 F G C G LA ME+ + L L+ F+ K P + + +V +V Sbjct: 387 ISHSTFGGGPHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEGETP--IYHSGIVAAVENV 444 Query: 480 P 480 P Sbjct: 445 P 445 >4C9K-A nrPDB Length = 421 Score = 90.9 bits (224), Expect = 1e-18, Method: Composition-based stats. Identities = 71/466 (15%), Positives = 134/466 (28%), Gaps = 85/466 (18%) Query: 30 PPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGP------VFTLYFGLKPIVVLHGYEAV 83 PP P +I I + + + K V+T + G + + Sbjct: 16 PPPHVPGHLIREIDAYDLDGLEQGFHEAWKRVQQPDTPPLVWTPFTGGH--WIATRGTLI 73 Query: 84 KEALIDLGEEFSGRGIFPLAERANRGFGIVF------SNGKKWKEIRRFSLMTLRNFGMG 137 E E FS R R G + + + R+ L + Sbjct: 74 DEI-YRSPERFSSR-----VIWVPREAGEAYDMVPTKLDPPEHTPYRKAIDKGLNLAEI- 126 Query: 138 KRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFD--YKDQQFL 195 R +ED+++ A ++E F F + + FL Sbjct: 127 -RKLEDQIRTIAVEIIEGFADRG-------------------HCEFGSEFSTVFPVRVFL 166 Query: 196 NLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESM 255 L E+ L ++ T + +++ E V + Sbjct: 167 ALAGLPVEDATKLGLLANEMTRPSG-------NTPEEQGRSLEAANKGFFEYVAPIIAAR 219 Query: 256 DMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLK 315 + D I L + L G +T L + ++ L + Sbjct: 220 RGGSGTDLITRILNVEI-----DGKPMPDDRALGLVSLLLLGGLDTVVNFLGFMMIYLSR 274 Query: 316 HPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIK 375 HPE A+++ E + V E+ R ++ + V D++ Sbjct: 275 HPETVAEMRREPLK------------------LQRGVEELFRRFAVVSDA--RYVVSDME 314 Query: 376 FRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRIC 435 F ++ +G IL+ D++ +P D + F+ G C Sbjct: 315 FHGTMLKEGDLILLPTALHGLDDRHHDDPMTVDLSR---------RDVTHSTFAQGPHRC 365 Query: 436 VGEALAGMELFLFLTSILQNFNLKSLVD-PKNLDTTPVVNGFASVP 480 G LA +E+ + L L L D + + +V ++P Sbjct: 366 AGMHLARLEVTVMLQEWLARIPEFRLKDRAVPIYHSGIVAAVENIP 411 >3AWQ-A nrPDB Length = 415 Score = 90.5 bits (223), Expect = 2e-18, Method: Composition-based stats. Identities = 28/151 (18%), Positives = 54/151 (35%), Gaps = 15/151 (9%) Query: 342 RSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEF 401 Y + V EV+R+ P + + D ++ P+G +++ L HD + Sbjct: 268 VQQPDYAELFVQEVRRFYPFFPAVVAR-ASQDFEWEGMAFPEGRQVVLDLYGSNHDAATW 326 Query: 402 PNPEMFDPHHFLDEGGNFKKSKYFMPFSAGK----RICVGEALAGMELFLFLTSILQNFN 457 +P+ F P F + S F+P G C GE + + + ++ Sbjct: 327 ADPQEFRPERF---RAWDEDSFNFIPQGGGDHYLGHRCPGEWIVLAIMKVAAHLLVNAMR 383 Query: 458 LKSLVDPKNLDTTPVVNGFASVPPFYQLCFI 488 ++D FA +P + F+ Sbjct: 384 YDVPDQDLSID-------FARLPALPKSGFV 407 >2RCM-A nrPDB Length = 495 Score = 81.7 bits (200), Expect = 8e-16, Method: Composition-based stats. Identities = 67/495 (13%), Positives = 138/495 (27%), Gaps = 85/495 (17%) Query: 19 LWRQSSGRGKLP------------------PGPTPLPVIGNILQ----IGIKDISKSLTN 56 + +++S + P PG LP++G I + + + Sbjct: 1 MAKKTSSGSETPDLTVATRTGSKDLPIRNIPGNYGLPIVGPIKDRWDYFYDQGAEEFFKS 60 Query: 57 LSKVY-GPVFTLYFGL-------KPIVVLHGYEAVKEAL----IDLGEEFSGRGIFPLAE 104 + Y V+ + +V L ++ ++ + +G + + Sbjct: 61 RIRKYNSTVYRVNMPPGAFIAENPQVVALLDGKSFPVLFDVDKVEKKDLLTG--TYMPST 118 Query: 105 RANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKA--S 162 G+ I+ + + + + I Q L + L K + Sbjct: 119 ELTGGYRILSYLDPSEPKHEKLKNLLFFLLKSSRNRIFPEFQATYSELFDSLEKELSLKG 178 Query: 163 PCDPTFILGCAPCNVICSIIFHK-----RFDYKDQQFLNLMEKLNENIKILSSPWIQICN 217 D N + + + + N + + I Sbjct: 179 KADFGGSSDGTAFNFLARAFYGTNPADTKLKADAPGLITKWVLFNLHPLLSIGLPRVIEE 238 Query: 218 NFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQ-ESMDMNNPQDFIDCFLMKMEKEKH 276 P+I F + + + + LE E E+ + ++ L+ Sbjct: 239 ---PLIHTFSLPPALVKSDYQRLYEFFLESAGEILVEADKLGISREEATHNLLFATCFNT 295 Query: 277 NQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNR- 335 + N + AG +V ++ EEI VI N Sbjct: 296 WGGMKI---LFPNMVKRIGRAGH------------------QVHNRLAEEIRSVIKSNGG 334 Query: 336 SPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNY----LIPKGTTILISL 391 M M T +VV+E R+ + D+ ++ + G + Sbjct: 335 ELTMGAIEKMELTKSVVYECLRFEPPVTAQYGR-AKKDLVIESHDAAFKVKAGEMLYGYQ 393 Query: 392 TSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGK---------RICVGEALAG 442 D K F + F P F+ E G K + +S G + C G+ Sbjct: 394 PLATRDPKIFDRADEFVPERFVGEEGE--KLLRHVLWSNGPETETPTVGNKQCAGKDFVV 451 Query: 443 MELFLFLTSILQNFN 457 + LF+ I + ++ Sbjct: 452 LVARLFVIEIFRRYD 466 >3DBM-A nrPDB Length = 473 Score = 70.9 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 73/468 (15%), Positives = 149/468 (31%), Gaps = 72/468 (15%) Query: 31 PGPTPLPV---IGNILQI--GIKDISKSLTNLSKVY-GPVFTLYFGLKPIV-------VL 77 PG +P I + L+ G + + + Y VF P V VL Sbjct: 12 PGSYGIPFFQPIKDRLEYFYGTGGRDEYFRSRMQKYQSTVFRANMPPGPFVSSNPKVIVL 71 Query: 78 HGYEAVKEAL----IDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRN 133 ++ ++ + F+G + + + G+ ++ + + Sbjct: 72 LDAKSFPILFDVSKVEKKDLFTG--TYMPSTKLTGGYRVLSYLDPSEPRHAQLKNLLFFM 129 Query: 134 FGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVI---CSIIFHKRFDYK 190 + + + L E L A G A N + + F R + Sbjct: 130 LKNSSNRVIPQFETTYTELFEGLEAELAKN-------GKAAFNDVGEQAAFRFLGRAYFN 182 Query: 191 DQQFLNLMEKLNENIKILSSPWIQICNNFSPIID-----YFPGTHNKLLKNVAFMKSYIL 245 KL + L S W + N +P +D + + AF+ Sbjct: 183 SN---PEETKLGTSAPTLISSW--VLFNLAPTLDLGLPWFLQEPLLHTFRLPAFLIKSTY 237 Query: 246 EKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETT-ST 304 K+ ++ +S+ + + EK P + + ++ G + Sbjct: 238 NKLYDYFQSVATP----------VMEQAEKLGVPKDEAVHNILFAVCFNTFGGVKILFPN 287 Query: 305 TLRYALLLLLKHPEVTAKVQEEIERVIGR--NRSPCMQDRSHMPYTDAVVHEVQRYIDLL 362 TL++ L ++ + EEI I + + ++ MP T +VV+E R + Sbjct: 288 TLKWIGLA-GENLHTQ--LAEEIRGAIKSYGDGNVTLEAIEQMPLTKSVVYESLRIEPPV 344 Query: 363 PTSLPHAVTCDIKFRNYL----IPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGN 418 P + ++ + KG + D K F PE + P F+ +G Sbjct: 345 PPQYG-KAKSNFTIESHDATFEVKKGEMLFGYQPFATKDPKVFDRPEEYVPDRFVGDGEA 403 Query: 419 FKKSKYFMPFSAGK---------RICVGEALAGMELFLFLTSILQNFN 457 K ++ +S G + C G+ + LF+ + + ++ Sbjct: 404 LLK---YVWWSNGPETESPTVENKQCAGKDFVVLITRLFVIELFRRYD 448 >2YJN-B nrPDB Length = 381 Score = 58.6 bits (140), Expect = 7e-09, Method: Composition-based stats. Identities = 21/138 (15%), Positives = 46/138 (33%), Gaps = 20/138 (14%) Query: 288 ENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPY 347 + A+ AG E T+ T+ A+L + P + ++ ++ Sbjct: 213 ADPALRALFAGAEMTANTVVDAVLAVSAEPGLAERIADDPAA------------------ 254 Query: 348 TDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMF 407 V EV R T +++ ++I +G +++ + + D + F P+ Sbjct: 255 AQRTVAEVLRL-HPALHLERRTATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDRL 313 Query: 408 DPHHFLDEGGNFKKSKYF 425 D D + Sbjct: 314 DVDR-PDADRALSAHRGH 330 >4YXC-B nrPDB Length = 227 Score = 36.2 bits (82), Expect = 0.034, Method: Composition-based stats. Identities = 23/121 (19%), Positives = 47/121 (38%), Gaps = 7/121 (5%) Query: 272 EKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVI 331 E++ N PS+ +L++ D TT+ + A+ L +V+ +Q+ I Sbjct: 90 EEQPKNNPSDENTGALDDLWADALNEQKATTTKSAADAVFQQLGGGDVSGAMQD-----I 144 Query: 332 GRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTC--DIKFRNYLIPKGTTILI 389 ++ + T + E+ R +L DI YLI +G +++ Sbjct: 145 DLIMDIPVKLTVELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVV 204 Query: 390 S 390 + Sbjct: 205 A 205 >4YXB-D nrPDB Length = 80 Score = 33.1 bits (74), Expect = 0.26, Method: Composition-based stats. Identities = 10/49 (20%), Positives = 19/49 (38%), Gaps = 2/49 (4%) Query: 344 HMPYTDAVVHEVQRYIDLLPTSLPHAVTC--DIKFRNYLIPKGTTILIS 390 + T + E+ R +L DI YLI +G ++++ Sbjct: 10 ELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVVA 58 >4DJD-D nrPDB Length = 323 Score = 32.4 bits (72), Expect = 0.52, Method: Composition-based stats. Identities = 15/45 (33%), Positives = 24/45 (53%), Gaps = 10/45 (22%) Query: 290 TAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRN 334 TA L AG +LL++HPE A+V+E I++++ N Sbjct: 287 TATALLQAGAH----------ILLMRHPEAVARVKENIDQLMVSN 321 >5C8J-I nrPDB Length = 207 Score = 29.3 bits (64), Expect = 3.5, Method: Composition-based stats. Identities = 12/36 (33%), Positives = 19/36 (52%) Query: 313 LLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYT 348 + K+PE+ K+QEE +R++ N M YT Sbjct: 71 MSKNPEMMEKLQEEQQRIMQLNAELMKMSFRPMIYT 106 >6FEC-u nrPDB Length = 636 Score = 29.3 bits (64), Expect = 3.6, Method: Composition-based stats. Identities = 12/66 (18%), Positives = 25/66 (37%), Gaps = 3/66 (4%) Query: 317 PEVTAKVQE-EIERVIGRNRSPCMQDRSHMPY--TDAVVHEVQRYIDLLPTSLPHAVTCD 373 P +E I+R P ++PY T+ + E R +++ LP + Sbjct: 99 PTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEESIKEFFRGLNISAVRLPREPSNP 158 Query: 374 IKFRNY 379 + + + Sbjct: 159 ERLKGF 164 >2NYG-A nrPDB Length = 273 Score = 28.5 bits (62), Expect = 6.4, Method: Composition-based stats. Identities = 11/37 (29%), Positives = 20/37 (54%), Gaps = 2/37 (5%) Query: 378 NYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLD 414 + + +GT ++ S + L D KE+ NP + P + D Sbjct: 58 DVVTEEGTIVMPSQSVELSDPKEWGNPPV--PEEWWD 92 >3RFT-A nrPDB Length = 267 Score = 28.5 bits (62), Expect = 6.9, Method: Composition-based stats. Identities = 14/55 (25%), Positives = 15/55 (27%), Gaps = 11/55 (20%) Query: 389 ISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGM 443 I S H +P E P G G C GE LA M Sbjct: 106 IVFASSNHTIGYYPQTERLGPDVPARPDGL-----------YGVSKCFGENLARM 149 >4YB9-D nrPDB Length = 479 Score = 28.1 bits (61), Expect = 8.0, Method: Composition-based stats. Identities = 13/47 (27%), Positives = 25/47 (53%), Gaps = 3/47 (6%) Query: 444 ELFLFLTSILQN-FNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIP 489 +LF+ + ++ F L+SL+ + P++ G +P QL F+P Sbjct: 167 QLFITIGILVAQIFGLRSLLANEEG--WPILLGLTGIPAVLQLLFLP 211 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.132 0.351 Lambda K H 0.267 0.0405 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,100,768 Number of Sequences: 36641 Number of extensions: 730494 Number of successful extensions: 2976 Number of sequences better than 10.0: 180 Number of HSP's better than 10.0 without gapping: 252 Number of HSP's successfully gapped in prelim test: 69 Number of HSP's that attempted gapping in prelim test: 2060 Number of HSP's gapped (non-prelim): 348 length of query: 490 length of database: 10,336,785 effective HSP length: 101 effective length of query: 389 effective length of database: 6,636,044 effective search space: 2581421116 effective search space used: 2581421116 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 61 (28.1 bits)