BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P11511 (503 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3S79-A nrPDB 1043 0.0 4R20-A nrPDB 95 8e-20 3E6I-A nrPDB 94 1e-19 3EL3-A nrPDB 94 2e-19 3MDV-A nrPDB 87 2e-17 5VEU-A nrPDB 84 2e-16 6B82-A nrPDB 82 4e-16 6C94-A nrPDB 82 6e-16 3DL9-A nrPDB 80 2e-15 3JUS-A nrPDB 79 4e-15 4R1Z-A nrPDB 78 8e-15 4KPA-A nrPDB 78 1e-14 2VE3-A nrPDB 77 2e-14 6DA2-A nrPDB 77 3e-14 3K9V-A nrPDB 76 3e-14 2PG7-A nrPDB 76 3e-14 5UYS-A nrPDB 75 6e-14 5JLC-A nrPDB 74 1e-13 2NNH-A nrPDB 73 2e-13 3IBD-A nrPDB 70 2e-12 5E0E-A nrPDB 70 3e-12 5W0C-A nrPDB 69 5e-12 5VBU-A nrPDB 69 5e-12 3TBG-A nrPDB 69 6e-12 3MZS-A nrPDB 68 1e-11 2W0A-A nrPDB 67 1e-11 4H1N-A nrPDB 66 3e-11 4GQS-A nrPDB 66 4e-11 5E58-A nrPDB 66 4e-11 6DWN-A nrPDB 65 6e-11 1N6B-A nrPDB 65 9e-11 5YLW-A nrPDB 64 1e-10 4WMZ-A nrPDB 62 5e-10 3QZ1-A nrPDB 62 5e-10 2HI4-A nrPDB 61 1e-09 6AYB-A nrPDB 61 1e-09 6CR2-A nrPDB 60 3e-09 6M7X-A nrPDB 59 6e-09 3N9Z-A nrPDB 57 1e-08 5FOI-A nrPDB 55 8e-08 6IQ5-A nrPDB 54 1e-07 4ZGX-A nrPDB 53 3e-07 5FSA-A nrPDB 52 6e-07 1CPT-A nrPDB 51 9e-07 6B11-A nrPDB 51 1e-06 6A7J-A nrPDB 50 2e-06 3NC3-A nrPDB 49 3e-06 3SN5-A nrPDB 49 5e-06 3R9C-A nrPDB 49 5e-06 2RFC-A nrPDB 49 6e-06 4YZR-A nrPDB 48 1e-05 5XJN-A nrPDB 48 1e-05 5GWE-A nrPDB 48 1e-05 6A7I-A nrPDB 48 1e-05 1WIY-A nrPDB 47 1e-05 5Y1I-A nrPDB 47 2e-05 3ABB-A nrPDB 46 4e-05 6F0B-A nrPDB 45 5e-05 6FYJ-A nrPDB 45 6e-05 5OFQ-A nrPDB 45 9e-05 4OQR-A nrPDB 44 1e-04 2ZQJ-A nrPDB 44 1e-04 1LG9-A nrPDB 44 1e-04 1EHE-A nrPDB 44 2e-04 4OQS-A nrPDB 44 2e-04 5YHJ-A nrPDB 42 5e-04 2Z36-A nrPDB 42 5e-04 3TKT-A nrPDB 42 6e-04 5FYF-A nrPDB 42 7e-04 3RWL-A nrPDB 42 7e-04 3WEC-A nrPDB 42 8e-04 5L94-A nrPDB 41 0.001 4UBS-A nrPDB 41 0.001 1GWI-A nrPDB 41 0.001 3P3Z-A nrPDB 41 0.001 6GK6-A nrPDB 40 0.002 5D3U-A nrPDB 40 0.002 5HDI-A nrPDB 40 0.002 5IT1-A nrPDB 40 0.002 6HQG-A nrPDB 39 0.005 6DCD-A nrPDB 39 0.005 3B98-A nrPDB 39 0.005 3TYW-A nrPDB 39 0.005 6FSH-A nrPDB 39 0.007 3EJB-B nrPDB 39 0.008 4TX3-A nrPDB 38 0.008 3ABA-A nrPDB 38 0.008 6HQD-A nrPDB 38 0.009 5EX6-C nrPDB 38 0.011 1UED-A nrPDB 38 0.012 2Y5N-A nrPDB 37 0.023 4JBT-A nrPDB 37 0.025 2ZBZ-A nrPDB 37 0.027 2WIY-A nrPDB 36 0.032 5L1U-A nrPDB 36 0.038 3DBM-A nrPDB 35 0.055 6G5O-A nrPDB 35 0.055 4PWV-A nrPDB 35 0.056 3R75-A nrPDB 35 0.056 4XE3-A nrPDB 35 0.066 2RCM-A nrPDB 35 0.086 5DE9-A nrPDB 35 0.10 2X9P-A nrPDB 34 0.12 3NV6-A nrPDB 34 0.12 5XNT-A nrPDB 34 0.13 5DQN-A nrPDB 33 0.28 5CJE-A nrPDB 33 0.43 4TRI-A nrPDB 33 0.43 3WVS-A nrPDB 32 0.46 5JVP-A nrPDB 32 0.63 6HQW-A nrPDB 32 0.66 6M7L-A nrPDB 32 0.79 5OMS-A nrPDB 32 0.79 4MM0-A nrPDB 32 0.80 1UE8-A nrPDB 32 0.86 4YT3-A nrPDB 32 0.86 4Z5P-A nrPDB 31 0.96 4Z5Q-A nrPDB 31 1.1 6GII-A nrPDB 31 1.2 3A7C-A nrPDB 30 1.6 1F4U-A nrPDB 30 1.7 1ODO-A nrPDB 30 1.8 5D3I-A nrPDB 30 2.0 1Q5D-A nrPDB 30 2.1 5OQL-V nrPDB 30 2.2 5EX8-A nrPDB 30 2.5 2VA8-A nrPDB 29 4.8 5KYO-A nrPDB 29 5.0 1TQY-B nrPDB 29 5.1 2PFY-A nrPDB 29 6.0 5H1Z-A nrPDB 28 9.5 5YSW-A nrPDB 28 9.9 >3S79-A nrPDB Length = 503 Score = 1043 bits (2698), Expect = 0.0, Method: Compositional matrix adjust. Identities = 503/503 (100%), Positives = 503/503 (100%) Query: 1 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI 60 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI Sbjct: 1 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI 60 Query: 61 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL 120 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL Sbjct: 61 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL 120 Query: 121 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN 180 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN Sbjct: 121 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN 180 Query: 181 ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL 240 ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL Sbjct: 181 ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL 240 Query: 241 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI 300 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI Sbjct: 241 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI 300 Query: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI 360 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI Sbjct: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI 360 Query: 361 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK 420 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK Sbjct: 361 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK 420 Query: 421 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH Sbjct: 421 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480 Query: 481 PDETKNMLEMIFTPRNSDRCLEH 503 PDETKNMLEMIFTPRNSDRCLEH Sbjct: 481 PDETKNMLEMIFTPRNSDRCLEH 503 >4R20-A nrPDB Length = 486 Score = 94.7 bits (234), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 85/370 (22%), Positives = 159/370 (42%), Gaps = 18/370 (4%) Query: 130 KGIIFNNNPELWKTTRPFFMKALS--GPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDV 187 K I F + LWK R + + G G ++ T+ E+ + + L+ +S + V Sbjct: 102 KDIAFADYSPLWKNHRRLVHSSFTLFGEGSNKLQTIVQEAADSLCEELQACRGQSSDLSV 161 Query: 188 LTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKS 247 + L+R V +F + + Y D + + + WL K Sbjct: 162 V-LMRAVTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQTIARGGLVDIFPWLRIFPNKD 220 Query: 248 VKDLKDAIEV---LIAEKRRRISTEEKLEECMDFATELILAEKRG-----DLTRENVNQC 299 +K LK+ + + L+ +K E D L++ ++RG D+T ++V Sbjct: 221 LKRLKECVSIRDQLLYKKLLEHKKSLTPGEPRDLLDALLIGQQRGSGGADDITEDHVLMT 280 Query: 300 ILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-ERDIKIDDIQKLKVMEN 358 E A +T S +L + + + HP ++E + E+ +G +R + D L +++ Sbjct: 281 AAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSDRPHLPLLDA 340 Query: 359 FIYESMRYQPVVD-LVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLE 416 + E MR +PV L+ A++D + G+ V KGT +++N+ +H + + +P +F E Sbjct: 341 VLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWDQPEQFNPE 400 Query: 417 NF----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQ 472 F K F PFG GPR C G+ +A + + + L+RF + +Q Sbjct: 401 RFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFSCPSEASLPDLQ 460 Query: 473 KIHDLSLHPD 482 + L P+ Sbjct: 461 GRFGVVLQPE 470 >3E6I-A nrPDB Length = 476 Score = 94.0 bits (232), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 92/378 (24%), Positives = 170/378 (44%), Gaps = 33/378 (8%) Query: 112 YSSRFGSKLGLQCIGMH-EKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKT 170 Y F + L H ++GIIFNN P WK R F + L G+ + + Sbjct: 72 YKDEFSGRGDLPAFHAHRDRGIIFNNGPT-WKDIRRFSLTTLRNYGMGKQGNESRIQREA 130 Query: 171 HLDRLEEVTNESGY------------VDVLT-LLRRVMLDTSNTLFLRIP--LDESAIVV 215 H LE + G +V+ +L R D ++ FLR+ +E+ ++ Sbjct: 131 HF-LLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLL 189 Query: 216 KIQGYFDAWQALLIK-PDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRI--STEEKL 272 W L P + ++K K+V ++K+ + + E + + + L Sbjct: 190 ST-----PWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDL 244 Query: 273 EECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAI 332 +C+ E T + + + ++ A +T S +L + L ++ K+P +EE + Sbjct: 245 TDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKL 304 Query: 333 IKEIQTVIGERDI-KIDDIQKLKVMENFIYESMRYQPVVDLVM-RKALEDDVIDGYPVKK 390 +EI VIG I I D Q++ M+ ++E R+ +V + +A D + GY + K Sbjct: 305 HEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPK 364 Query: 391 GTNIILNIGR-MHRLEFFPKPNEFTLENF-AKNVPYR---YFQPFGFGPRGCAGKYIAMV 445 GT ++ + ++ + FP P +F E+F +N ++ YF+PF G R CAG+ +A + Sbjct: 365 GTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARM 424 Query: 446 MMKAILVTLLRRFHVKTL 463 + +L +L+ F++K L Sbjct: 425 ELFLLLCAILQHFNLKPL 442 >3EL3-A nrPDB Length = 467 Score = 94.0 bits (232), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 65/254 (25%), Positives = 126/254 (49%), Gaps = 23/254 (9%) Query: 242 KKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILA-EKRGD-LTRENVNQC 299 +++ ++ DL ++ +IAE+R ++ +K + D T L+ A + GD + + ++ Sbjct: 214 RRFNDALADLHLLVDEIIAERR---ASGQKPD---DLLTALLEAKDDNGDPIGEQEIHDQ 267 Query: 300 ILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENF 359 ++ +L +T++ ++ ++L +A HP + I E++ V G R + +D++KL+ N Sbjct: 268 VVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNV 327 Query: 360 IYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR--------LEFFPKPN 411 I E+MR +P V ++ R+A+ + + GY + G +II + + R LEF P Sbjct: 328 IVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDP--- 384 Query: 412 EFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQC---- 467 + L A NVP +PF G R C + +M + I L ++ + + G Sbjct: 385 DRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVR 444 Query: 468 VESIQKIHDLSLHP 481 V + HDL + P Sbjct: 445 VGITLRPHDLLVRP 458 >3MDV-A nrPDB Length = 456 Score = 87.0 bits (214), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 93/413 (22%), Positives = 179/413 (43%), Gaps = 36/413 (8%) Query: 77 YNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCI---GMHEKGII 133 + + YG +RV + + ++I++ S+ + Y+ LQ + + +G++ Sbjct: 19 WAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLV 78 Query: 134 FNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRR 193 N E W R A S LV ++ E + ++ LE + V + +L Sbjct: 79 SECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTY 138 Query: 194 VMLD----------TSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKK 243 +D TS L + PL + A+ + ++G + L +L K Sbjct: 139 TAMDILAKAAFGMETSMLLGAQKPLSQ-AVKLMLEGITASRNTL---------AKFLPGK 188 Query: 244 YEKSVKDLKDAIEVLIAE-----KRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQ 298 K +++++++I L +RRR + + E D T+++ AE+ G E + Sbjct: 189 -RKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEE-GAQDDEGLLD 246 Query: 299 CILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-ERDIKIDDIQKLKVME 357 + IA +T + L F + +++ P + + E+ VIG +R + +D+ +L+ + Sbjct: 247 NFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLS 306 Query: 358 NFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLE 416 + ES+R P R E+ +IDG V T ++ + M R++ +F P F + Sbjct: 307 QVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPD 366 Query: 417 NFAKNVP---YRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQ 466 F P + YF PF G R C G+ A + +K ++ LL+R + + GQ Sbjct: 367 RFGPGAPKPRFTYF-PFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQ 418 >5VEU-A nrPDB Length = 480 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 106/447 (23%), Positives = 200/447 (44%), Gaps = 51/447 (11%) Query: 47 IPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGE---ETLIISKSSSM 103 IPGP +G ++S+ + LW + Y ++ ++W + E L I+ + Sbjct: 17 IPGPTPLPLLGNVLSYRQGLW-------KFDTECYKKYGKMWGTYEGQLPVLAITDPDVI 69 Query: 104 FHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTV 163 ++ YS F ++ L +G + I + E WK R + L M + Sbjct: 70 RTVLVKECYSV-FTNRRSLGPVGFMKSAISLAEDEE-WKRIRSLLSPTFTSGKLKEMFPI 127 Query: 164 CAE-------SLKTHLDRLEEVTNESGY----VDVLTLLR-RVMLDTSNTLFLRIPLDES 211 A+ +L+ ++ + VT + + +DV+T V +D+ N + P ES Sbjct: 128 IAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNP--QDPFVES 185 Query: 212 AIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAE----KRRRIS 267 G+ D L + +F ++ +++ S+ KD I L K+ R++ Sbjct: 186 TKKFLKFGFLDP---LFLSIILFPFLTPVFEALNVSLFP-KDTINFLSKSVNRMKKSRLN 241 Query: 268 TEEKLEECMDFATELILAEKRGDLTRENVNQCILEM-------LIAAPDTMSVSLFFMLF 320 ++K +DF +L++ + T + LE+ + A +T S L F L+ Sbjct: 242 DKQK--HRLDFL-QLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLY 298 Query: 321 LIAKHPNVEEAIIKEIQTVIGERDIKI-DDIQKLKVMENFIYESMRYQPVVDLVMRKALE 379 +A HP+V++ + KEI V+ + D + +++ ++ + E++R PV + R + Sbjct: 299 ELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKK 358 Query: 380 DDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNV----PYRYFQPFGFGP 434 D I+G + KG+ +++ +H +++ +P EF E F+K PY Y PFG GP Sbjct: 359 DVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY-TPFGTGP 417 Query: 435 RGCAGKYIAMVMMKAILVTLLRRFHVK 461 R C G A++ MK L+ +L+ F K Sbjct: 418 RNCIGMRFALMNMKLALIRVLQNFSFK 444 >6B82-A nrPDB Length = 509 Score = 82.4 bits (202), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 96/392 (24%), Positives = 162/392 (41%), Gaps = 49/392 (12%) Query: 130 KGIIFNNNPELWKTTRPFFMKALS--GPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDV 187 K I F + WK R AL G G V + + + + L E N + VD+ Sbjct: 107 KDIAFADYSSTWKFHRKMVHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSA--VDL 164 Query: 188 LTLLRRVMLDTS-----NTLFLRIPLDESAIVVKIQGYFDA-----------WQALLIKP 231 L R + + N+ + R + +++ QG D W + Sbjct: 165 GPELTRAVTNVVCALCFNSSYKRGDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNK 224 Query: 232 D-------IFFKISWLYKKYEKSVKDLKDAIE--VLIAEKRRRISTEEKLEECMDFATEL 282 D I + L KKYE+ D ++ +L A R + S+E D Sbjct: 225 DLRILRQCISIRDKLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVG--- 281 Query: 283 ILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG- 341 LT ++V + E+ A +T + +L + + + +P V+ I +E+ + IG Sbjct: 282 --------LTEDHVLMTVGEIFGAGVETTTTTLKWSIAYLVHNPQVQRKIQEELDSKIGK 333 Query: 342 ERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRK-ALEDDVIDGYPVKKGTNIILNIGR 400 ER ++ D L +E I E MR +PV L++ AL+D + Y V+KGT +++N+ Sbjct: 334 ERHPQLSDRGNLPYLEATICEVMRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINMWS 393 Query: 401 MHRLEF-FPKPNEFTLENFAKN------VPYRYFQPFGFGPRGCAGKYIAMVMMKAILVT 453 +H E + P F F P + PFG G R C G+ +A + + L Sbjct: 394 LHHDEKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAW 453 Query: 454 LLRRFHVKTLQGQCVESIQKIHDLSLHPDETK 485 +L+RF ++ GQ + +Q + L P + K Sbjct: 454 ILQRFTLEMPTGQPLPDLQGKFGVVLQPKKFK 485 >6C94-A nrPDB Length = 497 Score = 82.0 bits (201), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 82/370 (22%), Positives = 166/370 (44%), Gaps = 47/370 (12%) Query: 122 LQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNE 181 LQ IG KG++ + P+ W R L V + A+S + L++ E+ E Sbjct: 97 LQWIG---KGLLVLDGPK-WFQHRKLLTPGFHYDVLKPYVAIFADSTRIMLEKWEKKACE 152 Query: 182 SGYVDVLTLLRRVMLDT----------------SNTLFLRIPLDESAIVVKIQGYFDAWQ 225 D+ + + + LDT ++ ++ + S + + +Q D++Q Sbjct: 153 GKSFDIFSDVGHMALDTLMKCTFGKGDSGLNHRDSSYYVAV----SELTLLMQQRIDSFQ 208 Query: 226 ALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEEC-----MDFAT 280 D + ++ +++ ++ + D + +I +++ + E++ E+ +DF Sbjct: 209 ---YHNDFIYWLTPHGRRFLRACRAAHDHTDRVIRQRKAALQDEKEREKIQNRRHLDFLD 265 Query: 281 ELILAEKRGD----LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEI 336 IL + RG+ L+ ++ + + DT + + + L+ +A +P ++ +E+ Sbjct: 266 --ILLDVRGESGVQLSDTDLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQRCREEV 323 Query: 337 QTVIGERD-IKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALED-DVIDGYPVKKGTNI 394 + ++G++D + +D+ K+ + + E R P V V R+ + +DG + G+ I Sbjct: 324 REILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQVYRQLSKPVSFVDGRSLPAGSLI 383 Query: 395 ILNIGRMHR-LEFFPKPN-----EFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMK 448 L+I +HR + +P P F+ EN + PY F PF GPR C G+ AM MK Sbjct: 384 SLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRHPYA-FIPFSAGPRNCIGQQFAMNEMK 442 Query: 449 AILVTLLRRF 458 + L RF Sbjct: 443 VVTALCLLRF 452 >3DL9-A nrPDB Length = 479 Score = 79.7 bits (195), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 52/177 (29%), Positives = 90/177 (50%), Gaps = 7/177 (3%) Query: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGER-DIKIDD 349 ++EN+ + E++IA +T + L + + +A +PN++ + KEI ++G DD Sbjct: 269 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 328 Query: 350 IQKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FF 407 K+ E ++E +R+ +V L + ED V+ GY + KGT +I N+ +H E ++ Sbjct: 329 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 388 Query: 408 PKPNEFTLENFAKNVPY----RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460 P F E F + Y PF G R C G+++A + M LL+RFH+ Sbjct: 389 RDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL 445 >3JUS-A nrPDB Length = 461 Score = 79.3 bits (194), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 80/340 (23%), Positives = 149/340 (43%), Gaps = 50/340 (14%) Query: 177 EVTNESGYVDVLTLLRRVMLDTSNTLF----LRIPLDE--SAIVVKIQGYFDAWQALLIK 230 E ESG +V L +++ T++ +R L+E + + + G F LL Sbjct: 136 ESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLP- 194 Query: 231 PDIFFKISWL----YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAE 286 WL +++ +++ +++KD I ++R+ ++EK+++ + + + Sbjct: 195 -------GWLPLPSFRRRDRAHREIKDIFYKAIQKRRQ---SQEKIDDILQTLLDATYKD 244 Query: 287 KRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGER--D 344 R LT + V ++ +L+A T S + +M F +A+ +++ E +TV GE Sbjct: 245 GR-PLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPP 303 Query: 345 IKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKG--------TNIIL 396 + D ++ L +++ I E++R +P + ++MR A + GY + G N L Sbjct: 304 LTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRL 363 Query: 397 NIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLR 456 + RL+F P+ + +N A + Y PFG G C G+ A V +K I T+LR Sbjct: 364 KDSWVERLDF--NPDRYLQDNPASGEKFAYV-PFGAGRHRCIGENFAYVQIKTIWSTMLR 420 Query: 457 RFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRN 496 + + G T N MI TP N Sbjct: 421 LYEFDLIDGYF---------------PTVNYTTMIHTPEN 445 >4R1Z-A nrPDB Length = 439 Score = 78.2 bits (191), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 93/392 (23%), Positives = 159/392 (40%), Gaps = 49/392 (12%) Query: 130 KGIIFNNNPELWKTTRPFFMKALS--GPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDV 187 K I F + WK R AL G G V + + + + L E N + VD+ Sbjct: 43 KDIAFADYSSTWKFHRKMVHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSA--VDL 100 Query: 188 LTLLRRVMLDTS-----NTLFLRIPLDESAIVVKIQGYFDA-----------WQALLIKP 231 L R + + N+ + R + +++ QG D W + Sbjct: 101 GPELTRAVTNVVCALCFNSSYKRGDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNK 160 Query: 232 D-------IFFKISWLYKKYEKSVKDLKDAIE--VLIAEKRRRISTEEKLEECMDFATEL 282 D I + L KKYE+ D ++ +L A R + S+E D Sbjct: 161 DLTILRQCISIRDKLLQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVG--- 217 Query: 283 ILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG- 341 LT ++V + ++ A +T + L + + + +P V+ I +E+ + IG Sbjct: 218 --------LTEDHVLMTVGDIFGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGK 269 Query: 342 ERDIKIDDIQKLKVMENFIYESMRYQPVVDLVM-RKALEDDVIDGYPVKKGTNIILNIGR 400 ER ++ D L +E I E +R +PV L++ AL+D + Y V+KGT +++N+ Sbjct: 270 ERHPQLSDRGNLPYLEATIREVLRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINLWS 329 Query: 401 MHR-------LEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVT 453 +H E F E P + PFG G R C G+ +A + + L Sbjct: 330 LHHDKKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAW 389 Query: 454 LLRRFHVKTLQGQCVESIQKIHDLSLHPDETK 485 +L+RF ++ GQ + +Q + L P + K Sbjct: 390 ILQRFTLEMPTGQPLPDLQGKFGVVLQPKKFK 421 >4KPA-A nrPDB Length = 494 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 57/222 (25%), Positives = 111/222 (50%), Gaps = 8/222 (3%) Query: 242 KKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCIL 301 +++++ +K + D ++ +IA+++ ++ E+ ++ + E L EN+ I+ Sbjct: 227 RQFQEDIKVMNDLVDKIIADRK---ASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQII 283 Query: 302 EMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIY 361 LIA +T S L F L+ + K+P+V + +E V+ + +++LK + + Sbjct: 284 TFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLN 343 Query: 362 ESMRYQPVVDLVMRKALEDDVIDG-YPVKKGTNIILNIGRMHRLE--FFPKPNEFTLENF 418 E++R P A ED V+ G YP++KG +++ I ++HR + + EF E F Sbjct: 344 EALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERF 403 Query: 419 --AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 +P F+PFG G R C G+ A+ +L +L+ F Sbjct: 404 ENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHF 445 >2VE3-A nrPDB Length = 444 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 70/296 (23%), Positives = 131/296 (44%), Gaps = 32/296 (10%) Query: 191 LRRVMLDTSNTLFLRIPLDESAIVVK-----IQGYFDAWQALLIKPDIFFKISWLYKKYE 245 LRR+ D + TLF+ + ++ + IQG F L P+ F S Sbjct: 147 LRRMTFDVAATLFMGEKVSQNPQLFPWFETYIQGLFSLPIPL---PNTLFGKS------- 196 Query: 246 KSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD---LTRENVNQCILE 302 + A +L+AE + I ++ + A ++LA + + L+ + IL Sbjct: 197 ------QRARALLLAELEKIIKARQQQPPSEEDALGILLAARDDNNQPLSLPELKDQILL 250 Query: 303 MLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYE 362 +L A +T++ +L L+ +H ++ E + +E + +++ + ++K+ ++ + E Sbjct: 251 LLFAGHETLTSALSSFCLLLGQHSDIRERVRQEQNKLQLSQELTAETLKKMPYLDQVLQE 310 Query: 363 SMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAK- 420 +R P V R+ ++D G+ KG + I + H + +P P +F E F Sbjct: 311 VLRLIPPVGGGFRELIQDCQFQGFHFPKGWLVSYQISQTHADPDLYPDPEKFDPERFTPD 370 Query: 421 -----NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESI 471 N P+ + PFG G R C GK A + MK L+++F L GQ +E + Sbjct: 371 GSATHNPPFAHV-PFGGGLRECLGKEFARLEMKLFATRLIQQFDWTLLPGQNLELV 425 >6DA2-A nrPDB Length = 487 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 103/441 (23%), Positives = 185/441 (41%), Gaps = 38/441 (8%) Query: 47 IPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHI 106 IPGP +G ++S+ + M Y +V+G + G++ ++ M Sbjct: 18 IPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWG-----FYDGQQPVLAITDPDMIKT 72 Query: 107 MKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAE 166 + S F ++ +G + I + E WK R + L MV + A+ Sbjct: 73 VLVKECYSVFTNRRPFGPVGFMKSAISIAEDEE-WKRLRSLLSPTFTSGKLKEMVPIIAQ 131 Query: 167 S---LKTHLDRLEEVTNESGYVDVLTLLR-RVMLDTS---NTLFLRIPLDESAIVVKIQG 219 L +L R E DV V+ TS N L P D K Sbjct: 132 YGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLL 191 Query: 220 YFDAWQALLIKPDIF-FKISWL------------YKKYEKSVKDLKDAIEVLIAEKRRRI 266 FD + +F F I L KSVK +K++ L ++ R+ Sbjct: 192 RFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKES--RLEDTQKHRV 249 Query: 267 STEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHP 326 + + + + + E + DL E V Q I+ + A +T S L F+++ +A HP Sbjct: 250 DFLQLMIDSQN-SKETESHKALSDL--ELVAQSII-FIFAGYETTSSVLSFIMYELATHP 305 Query: 327 NVEEAIIKEIQTVIGERDIKI-DDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDG 385 +V++ + +EI V+ + D + +++ ++ + E++R P+ + R +D I+G Sbjct: 306 DVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEING 365 Query: 386 YPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAK----NVPYRYFQPFGFGPRGCAGK 440 + KG +++ +HR +++ +P +F E F+K N+ + PFG GPR C G Sbjct: 366 MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGM 425 Query: 441 YIAMVMMKAILVTLLRRFHVK 461 A++ MK L+ +L+ F K Sbjct: 426 RFALMNMKLALIRVLQNFSFK 446 >3K9V-A nrPDB Length = 482 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 71/354 (20%), Positives = 164/354 (46%), Gaps = 39/354 (11%) Query: 141 WKTTRPFFMKALSGP-GLVRMVTVCAESLKTHLDRLEEVTNESGYV-DVLTLLRR----- 193 W+ R F K L P ++++ E L L+R++E+ +E G + D+ + L + Sbjct: 123 WQRVRSAFQKKLMKPVEIMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFES 182 Query: 194 --VMLDTSNTLFLRIPLDESAI--VVKIQGYFDAWQALLIKPDIFFKI--SWLYKKYEKS 247 ++L L+ +E A+ + I+ + +++ P K + +++ + + Sbjct: 183 ICLVLYEKRFGLLQKETEEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLA 242 Query: 248 VKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAA 307 + +++ I + +R S + DF ++ ++ L+++ + + E+ +AA Sbjct: 243 WDTIFKSVKPCIDNRLQRYSQQPG----ADFLCDIY---QQDHLSKKELYAAVTELQLAA 295 Query: 308 PDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDI-KIDDIQKLKVMENFIYESMRY 366 +T + SL ++L+ ++++P + +++E+Q+V+ + + +D++ + ++ + ESMR Sbjct: 296 VETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRL 355 Query: 367 QPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRY 426 P V R + V+ Y + KGT + LN + +E E+ K P R+ Sbjct: 356 TPSVPFTTRTLDKPTVLGEYALPKGTVLTLNTQVLGS-------SEDNFEDSHKFRPERW 408 Query: 427 FQ-----------PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVE 469 Q PFG G R C G+ +A + + L +++++ + + VE Sbjct: 409 LQKEKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIVATDNEPVE 462 >2PG7-A nrPDB Length = 476 Score = 75.9 bits (185), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 50/178 (28%), Positives = 90/178 (50%), Gaps = 7/178 (3%) Query: 294 ENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE-RDIKIDDIQK 352 +N+ L++ + +T+S +L + L+ KHP VE + +EI VIG+ R K +D K Sbjct: 267 KNLVMTTLQLFVGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAK 326 Query: 353 LKVMENFIYESMRYQPVVDLVM-RKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKP 410 + ME I+E R+ V+ + + R+ +D + + KGT + +G + R FF P Sbjct: 327 MPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNP 386 Query: 411 NEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQ 464 +F ++F + F PF G R C G+ +A + + T+++ F +K+ Q Sbjct: 387 QDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQ 444 >5UYS-A nrPDB Length = 494 Score = 75.5 bits (184), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 95/430 (22%), Positives = 178/430 (41%), Gaps = 42/430 (9%) Query: 79 RVYGEFMRVWISGEETLIISKSSSMFHIM--KHNHYSSRFGSKLGLQCIGMHEKGIIFNN 136 + YG V + + T+I+ ++ K +S R L + KGI F + Sbjct: 40 KKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGR-PQMATLDIASNNRKGIAFAD 98 Query: 137 NPELWKTTRPFFMK--ALSGPGLVRMVTVCAESLKTHLDRLEEVTNES------GYVDVL 188 + W+ R M AL G ++ + + + T D L +S +V V Sbjct: 99 SGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVT 158 Query: 189 TLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSV 248 ++ + +TS + + IQ Y + L K + + WL K++ Sbjct: 159 NVISLICFNTSYK-------NGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTL 211 Query: 249 KDLKDAIEVL------IAEKRRRISTEEKLEECMDFATELILAEKRGD---------LTR 293 + LK +++ I E + + + +D + + G+ L+ Sbjct: 212 EKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSD 271 Query: 294 ENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-ERDIKIDDIQK 352 ++ I ++ A +T + + + L + +P V++ + +EI +G R I D + Sbjct: 272 NHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNR 331 Query: 353 LKVMENFIYESMRYQPVVD-LVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEF-FPKP 410 L ++E I E +R +PV L+ KA D I + V KGT +I+N+ +H E + +P Sbjct: 332 LLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQP 391 Query: 411 NEFTLENFAKNV------PYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQ 464 ++F E F P + PFG GPR C G+ +A + I+ LL+RF ++ Sbjct: 392 DQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPD 451 Query: 465 GQCVESIQKI 474 + S++ I Sbjct: 452 DGQLPSLEGI 461 >5JLC-A nrPDB Length = 515 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 80/371 (21%), Positives = 154/371 (41%), Gaps = 60/371 (16%) Query: 130 KGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVT---NESGYVD 186 KG+I++ + F AL+ VR V + AE + + + N SG VD Sbjct: 118 KGVIYDCPNHRLMEQKKFVKGALTKEAFVRYVPLIAEEIYKYFRNSKNFKINENNSGIVD 177 Query: 187 VL-------------TLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDI 233 V+ +LL + M D +T F + D I F P++ Sbjct: 178 VMVSQPEMTIFTASRSLLGKEMRDKLDTDFAYLYSDLDKGFTPINFVF---------PNL 228 Query: 234 FFKISWLYKKYEKSVKDLKDAIEVLIAEKRRR--ISTEEKLEECMDFATELILAEKRGDL 291 + Y+K + + + + LI E+R + I + ++E M +T + + Sbjct: 229 PLE---HYRKRDHAQQAISGTYMSLIKERREKNDIQNRDLIDELMKNST----YKDGTKM 281 Query: 292 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE--RDIKIDD 349 T + + ++ +L+ T + + + L +A+ P+V+E + +E V+ +++ DD Sbjct: 282 TDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPDVQEELYQEQMRVLNNDTKELTYDD 341 Query: 350 IQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGTNIILNIGRMH-RLEF 406 +Q + ++ I E++R + + RK + D I Y V + +++++ G H + EF Sbjct: 342 LQNMPLLNQMIKETLRLHHPLHSLFRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEEF 401 Query: 407 FPKPNEFTLENF-----------AKNVPYRY----------FQPFGFGPRGCAGKYIAMV 445 FPKPNEF + + V Y + + PFG G C G+ A Sbjct: 402 FPKPNEFNIHRWDGDAASSSAAGGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAYC 461 Query: 446 MMKAILVTLLR 456 + ++ +R Sbjct: 462 QLGVLMSIFIR 472 >2NNH-A nrPDB Length = 476 Score = 73.2 bits (178), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 57/197 (28%), Positives = 97/197 (49%), Gaps = 7/197 (3%) Query: 274 ECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAII 333 +C E ++ + EN+ + ++ +A +T S +L + L L+ KHP V + Sbjct: 247 DCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQ 306 Query: 334 KEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDV-IDGYPVKKG 391 +EI VIG R + D + + ++E RY +V + A+ D Y + KG Sbjct: 307 EEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKG 366 Query: 392 TNII-LNIGRMHRLEFFPKPNEFTLENF-AKNVPYR---YFQPFGFGPRGCAGKYIAMVM 446 T I+ L +H + FP PN F +F KN ++ YF PF G R CAG+ +A + Sbjct: 367 TTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARME 426 Query: 447 MKAILVTLLRRFHVKTL 463 + L T+L+ F++K++ Sbjct: 427 LFLFLTTILQNFNLKSV 443 >3IBD-A nrPDB Length = 476 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 49/185 (26%), Positives = 86/185 (46%), Gaps = 7/185 (3%) Query: 285 AEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-ER 343 + + + +N+N L + A +T S +L + L+ K+P+V E + +EI+ VIG R Sbjct: 258 SNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHR 317 Query: 344 DIKIDDIQKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIGR-M 401 ++ D K+ E IYE R+ ++ + V + GY + K T + L + + Sbjct: 318 PPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTAL 377 Query: 402 HRLEFFPKPNEFTLENFAKN----VPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRR 457 H +F KP+ F ++F F PF G R C G+ IA + T+L+ Sbjct: 378 HDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQN 437 Query: 458 FHVKT 462 F + + Sbjct: 438 FSMAS 442 >5E0E-A nrPDB Length = 463 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 50/186 (26%), Positives = 90/186 (48%), Gaps = 9/186 (4%) Query: 285 AEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD 344 + + + +N+ +L + A +T S +L + L+ K+P+V E + KEI VIG Sbjct: 249 SNQHTEFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHR 308 Query: 345 I-KIDDIQKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYPVKKGTNI--ILNIGR 400 + ++D K+ E IYE R+ ++ + V K +D + GY + K T + IL+ Sbjct: 309 LPTLEDRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSA- 367 Query: 401 MHRLEFFPKPNEFTLENFAKN----VPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLR 456 +H ++F +P+ F ++F F PF G R C G+ IA + T+L+ Sbjct: 368 LHDPQYFEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQ 427 Query: 457 RFHVKT 462 F + + Sbjct: 428 NFSLSS 433 >5W0C-A nrPDB Length = 477 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 62/254 (24%), Positives = 121/254 (47%), Gaps = 27/254 (10%) Query: 220 YFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFA 279 YF L+K ++ F S++ +K VK+ +++++ ++ + +C Sbjct: 208 YFPGTHNKLLK-NVAFMKSYILEK----VKEHQESMD---------MNNPQDFIDCFLMK 253 Query: 280 TELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTV 339 E + + T E++ +++ A +T S +L + L L+ KHP V + +EI+ V Sbjct: 254 MEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERV 313 Query: 340 IG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDV-IDGYPVKKGTNIILN 397 IG R + D + + ++E RY ++ + A+ D+ Y + KGT I+++ Sbjct: 314 IGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILIS 373 Query: 398 IGR-MHRLEFFPKPNEFTLE-------NFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKA 449 + +H + FP P F NF K+ +YF PF G R C G+ +A + + Sbjct: 374 LTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKS---KYFMPFSAGKRICVGEALAGMELFL 430 Query: 450 ILVTLLRRFHVKTL 463 L ++L+ F++K+L Sbjct: 431 FLTSILQNFNLKSL 444 >5VBU-A nrPDB Length = 476 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 61/249 (24%), Positives = 115/249 (46%), Gaps = 17/249 (6%) Query: 247 SVKDLKDAIEVL--IAEKRRRISTEE----KLEECMDFATELI----LAEKRGDLTRENV 296 ++ LK AIE I E + R E + + MD+ + + + E G L +V Sbjct: 204 GLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHV 263 Query: 297 NQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG----ERDIKIDDIQK 352 + +++LI +T + +L + + + HP +++ + +E+ +G + D + Sbjct: 264 HMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRAR 323 Query: 353 LKVMENFIYESMRYQPVVDLVM-RKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKP 410 L ++ I E +R +PVV L + + I GY + +GT II N+ H E + +P Sbjct: 324 LPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERP 383 Query: 411 NEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVES 470 +EF + F + FG G R C G+ +A + + +L LL+ F + G + S Sbjct: 384 HEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLP-SGDALPS 442 Query: 471 IQKIHDLSL 479 +Q + S+ Sbjct: 443 LQPLPHCSV 451 >3TBG-A nrPDB Length = 479 Score = 68.6 bits (166), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 91/373 (24%), Positives = 150/373 (40%), Gaps = 43/373 (11%) Query: 125 IGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVR----------MVTVCAESLKTHLDR 174 G +G+ W+ R F + L GL + +CA + H R Sbjct: 90 FGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCA-AFANHSGR 148 Query: 175 -------LEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQAL 227 L++ S + LT RR D + FLR+ LD + +K + F + + Sbjct: 149 PFRPNGLLDKAV--SNVIASLTCGRRFEYD--DPRFLRL-LDLAQEGLKEESGF--LREV 201 Query: 228 LIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAE- 286 L + I L K + K ++ L+ E R T + + D TE LAE Sbjct: 202 LNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHR---MTWDPAQPPRDL-TEAFLAEM 257 Query: 287 ------KRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVI 340 EN+ + ++ A T S +L + L L+ HP+V+ + +EI VI Sbjct: 258 EKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVI 317 Query: 341 GE-RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDV-IDGYPVKKGTNIILNI 398 G+ R ++ D + I+E R+ +V L + D+ + G+ + KGT +I N+ Sbjct: 318 GQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNL 377 Query: 399 GRMHRLE-FFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVT 453 + + E + KP F E+F V F PF G R C G+ +A + + + Sbjct: 378 SSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTS 437 Query: 454 LLRRFHVKTLQGQ 466 LL+ F GQ Sbjct: 438 LLQHFSFSVPTGQ 450 >3MZS-A nrPDB Length = 486 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 59/215 (27%), Positives = 106/215 (49%), Gaps = 11/215 (5%) Query: 294 ENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDD-IQK 352 E+V I EML +T S++L + L+ +A+ NV+E + +E+ + + I +Q Sbjct: 275 EDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQM 334 Query: 353 LKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPN 411 + +++ I E++R P+ + R D V+ Y + T + + I M R FF P+ Sbjct: 335 VPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPD 394 Query: 412 EFTLENF-AKNVPYRYFQP--FGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCV 468 +F + +K+ +F+ FG+G R C G+ IA + M L+ +L F V+ Q + Sbjct: 395 KFDPTRWLSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEM---QHI 451 Query: 469 ESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH 503 + I +L L PD+ + ++F P N D H Sbjct: 452 GDVDTIFNLILTPDKP---IFLVFRPFNQDPPQAH 483 >2W0A-A nrPDB Length = 455 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 77/358 (21%), Positives = 149/358 (41%), Gaps = 44/358 (12%) Query: 130 KGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLT 189 + ++F+ +PE K AL G + A +++ + R+ E+G +D+L Sbjct: 85 EAVVFDASPERRKEM--LHNAALRG----EQMKGHAATIEDQVRRMIADWGEAGEIDLLD 138 Query: 190 LLRRVMLDTSNTLFL----RIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYE 245 + + TS+ + R LD K+ + L D + I ++ E Sbjct: 139 FFAELTIYTSSACLIGKKFRDQLD--GRFAKLYHELERGTDPLAYVDPYLPIESFRRRDE 196 Query: 246 KSVKDLKDAIEVLIAE-KRRRISTEEKLEECMDFATELILAEKRGDLTR---ENVNQCIL 301 ++ + L+A+ RI+ + D LI + R + + + Sbjct: 197 A-----RNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEITGMFI 251 Query: 302 EMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE-RDIKIDDIQKLKVMENFI 360 M+ A T S + + L + +H + A+I E+ + G+ R + ++++ +EN + Sbjct: 252 SMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQLENVL 311 Query: 361 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENFA 419 E++R P + ++MR A + + G+ + +G + + +R+ E FP P++F Sbjct: 312 KETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDF------ 365 Query: 420 KNVPYRYFQP-------------FGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQ 464 VP RY QP FG G C G A++ +KAI LLR + + Q Sbjct: 366 --VPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQ 421 >4H1N-A nrPDB Length = 479 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 50/185 (27%), Positives = 84/185 (45%), Gaps = 7/185 (3%) Query: 285 AEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE-R 343 ++ + +N+ +L + A +T S +L + L+ K+P+V E + KEI+ VIG R Sbjct: 258 SDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLKYPHVTERVQKEIEQVIGSHR 317 Query: 344 DIKIDDIQKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIGR-M 401 +DD K+ + I+E R ++ V +D GY + K T + + + Sbjct: 318 PPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRGYVIPKNTEVFPVLSSAL 377 Query: 402 HRLEFFPKPNEFTLENF--AKNVPYRY--FQPFGFGPRGCAGKYIAMVMMKAILVTLLRR 457 H +F PN F +F A R F PF G R C G+ IA + T+L+ Sbjct: 378 HDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRICLGEGIARTELFLFFTTILQN 437 Query: 458 FHVKT 462 F + + Sbjct: 438 FSIAS 442 >4GQS-A nrPDB Length = 477 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 55/200 (27%), Positives = 95/200 (47%), Gaps = 13/200 (6%) Query: 274 ECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAII 333 +C E ++ + T EN+ ++L A +T S +L + L L+ KHP V + Sbjct: 248 DCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQ 307 Query: 334 KEIQTVIGE-RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDV-IDGYPVKKG 391 +EI+ V+G R + D + + ++E RY ++ + A+ DV Y + KG Sbjct: 308 EEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKG 367 Query: 392 TNIILNIGR-MHRLEFFPKPNEFTLE-------NFAKNVPYRYFQPFGFGPRGCAGKYIA 443 T I+ ++ +H + FP P F NF K+ YF PF G R C G+ +A Sbjct: 368 TTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKS---NYFMPFSAGKRICVGEGLA 424 Query: 444 MVMMKAILVTLLRRFHVKTL 463 + + L +L+ F++K+L Sbjct: 425 RMELFLFLTFILQNFNLKSL 444 >5E58-A nrPDB Length = 493 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 85/366 (23%), Positives = 150/366 (40%), Gaps = 50/366 (13%) Query: 131 GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 190 G+IF+N E WK R F + + G+ + ++ DR++E V+ L Sbjct: 112 GMIFSNG-ERWKVLRRFSLATMRDFGMGK---------RSVEDRIQE--EAQCLVEELQK 159 Query: 191 LRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKD 250 + LD + LF I + +V + Y + L D+F++ L + V + Sbjct: 160 SQGAPLDPT-FLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFE 218 Query: 251 LKDAIEVLIAEKRRRISTEEKLEECMDFA---------------------TELILAEK-- 287 L R+I+ L+E +D+ T L+ EK Sbjct: 219 LFSGFMKYFPGAHRQIT--RNLQEILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEK 276 Query: 288 ---RGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD 344 + +N+ +L + A +T S +L + L+ K+P+V E + KEI VIG Sbjct: 277 SNQHTEFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHR 336 Query: 345 I-KIDDIQKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYPVKKGTNI--ILNIGR 400 + ++D K+ + I+E R+ + + K +D + GY + K T + IL+ Sbjct: 337 LPTLEDRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSA- 395 Query: 401 MHRLEFFPKPNEFTLENFAKN----VPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLR 456 +H ++F +P F ++F F PF G R C G+ IA + T+L+ Sbjct: 396 LHDPQYFEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQ 455 Query: 457 RFHVKT 462 F V + Sbjct: 456 NFSVSS 461 >6DWN-A nrPDB Length = 491 Score = 65.5 bits (158), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 59/234 (25%), Positives = 102/234 (43%), Gaps = 43/234 (18%) Query: 241 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI 300 YK +EK ++D + LI E++L+E + L+ E + + Sbjct: 243 YKTFEKG--HIRDITDSLIEH-----CQEKQLDENANV-----------QLSDEKIINIV 284 Query: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-ERDIKIDDIQKLKVMENF 359 L++ A DT++ ++ + L + +P V+ I +E+ TVIG R ++ D L ME F Sbjct: 285 LDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAF 344 Query: 360 IYESMRYQPVVDLVM-RKALEDDVIDGYPVKKGTNIILNIGRM-HRLEFFPKPNEFTLEN 417 I E+ R+ V + D + G+ + KG + +N ++ H + + P+EF Sbjct: 345 ILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEF---- 400 Query: 418 FAKNVPYRYFQP--------------FGFGPRGCAGKYIAMVMMKAILVTLLRR 457 +P R+ P FG G R C G+ IA + L LL+R Sbjct: 401 ----LPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQR 450 >1N6B-A nrPDB Length = 473 Score = 64.7 bits (156), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 56/194 (28%), Positives = 97/194 (50%), Gaps = 15/194 (7%) Query: 282 LILAEKRGDL--TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTV 339 LI E+ +L T E++ + ++ A +T S +L + L L+ KHP V + +EI+ V Sbjct: 250 LIKMEQENNLEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPEVAARVQEEIERV 309 Query: 340 IG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDV-IDGYPVKKGTNIILN 397 IG R + D ++ + I+E R+ ++ + A+ DV Y + KGT+II + Sbjct: 310 IGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFRNYFIPKGTDIITS 369 Query: 398 IGR-MHRLEFFPKPNEFT-------LENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKA 449 + +H + FP P F NF K+ YF PF G R C G+ +A + + Sbjct: 370 LTSVLHDEKAFPNPKVFDPGHFLDESGNFKKS---DYFMPFSAGKRMCVGEGLARMELFL 426 Query: 450 ILVTLLRRFHVKTL 463 L ++L+ F +++L Sbjct: 427 FLTSILQNFKLQSL 440 >5YLW-A nrPDB Length = 495 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 92/423 (21%), Positives = 181/423 (42%), Gaps = 56/423 (13%) Query: 78 NRVYGEFMRVWISGEETLIISKSSSMFHIMKHNH---YSSRFGSKLGLQCIGMHEK-GII 133 ++ YG M + + T+I+S S M + H H +S R ++ C H+K + Sbjct: 56 SKRYGPLMSIHLGSLYTVIVS-SPEMAKEILHRHGQVFSGRTIAQAVHACD--HDKISMG 112 Query: 134 FNNNPELWKTTRPFFMKAL-SGPGLVRMVTVCAESLKTHLDRLEEVTN--------ESGY 184 F W+ R + + S + + + L+ LD +++ ++ E+ + Sbjct: 113 FLPVASEWRDMRKICKEQMFSNQSMEASQGLRRQKLQQLLDHVQKCSDSGRAVDIREAAF 172 Query: 185 VDVLTLLRRVML-------DTSNTLFLRIPLDESAIVVKIQGYFDAW--------QALLI 229 + L L+ + D+ T+ + ++ A +V + + D + Q + Sbjct: 173 ITTLNLMSATLFSSQATEFDSKATMEFKEIIEGVATIVGVPNFADYFPILRPFDPQGVKR 232 Query: 230 KPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRG 289 + D+FF L K E + + E +R K ++ ++ ++I A + Sbjct: 233 RADVFF--GKLLAKIEGYLNER--------LESKRANPNAPKKDDFLEIVVDIIQANEF- 281 Query: 290 DLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDD 349 L + +L++ + DT + S+ + + + +P+ + E+++V G+ I +D+ Sbjct: 282 KLKTHHFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSVAGDEKI-VDE 340 Query: 350 --IQKLKVMENFIYESMRYQPVVDLVM-RKALEDDVIDGYPVKKGTNIILN---IGRMHR 403 + KL ++ I E MR P L++ RKA D ++GY + KGT I++N IGR Sbjct: 341 SAMPKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNGYLIPKGTQILINAYAIGRDPS 400 Query: 404 LEFFPKPNEFTLENFAKN-VPYR----YFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 + + P F E F N + ++ PFG G R C G +A ++ TL+ F Sbjct: 401 I--WTDPETFDPERFLDNKIDFKGQDYELLPFGSGRRVCPGMPLATRILHMATATLVHNF 458 Query: 459 HVK 461 K Sbjct: 459 DWK 461 >4WMZ-A nrPDB Length = 539 Score = 62.4 bits (150), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 48/256 (18%), Positives = 114/256 (44%), Gaps = 33/256 (12%) Query: 241 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD---LTRENVN 297 Y+K + + K + LI E+R+ +++ D L+ D +T + + Sbjct: 251 YRKRDHAQKAISGTYMSLIKERRKNNDIQDR-----DLIDSLMKNSTYKDGVKMTDQEIA 305 Query: 298 QCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVI--GERDIKIDDIQKLKV 355 ++ +L+ T + + ++L +A+ P+V++ + +E V+ G++++ D +Q++ + Sbjct: 306 NLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLQEMPL 365 Query: 356 MENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGTNIILNIGRMH-RLEFFPKPNE 412 + I E++R + + RK ++D + Y + G +++++ G H R E+FP ++ Sbjct: 366 LNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQ 425 Query: 413 FTLENFAKNVPYRY--------------------FQPFGFGPRGCAGKYIAMVMMKAILV 452 F + + + Y + PFG G C G++ A + ++ Sbjct: 426 FNIHRWNNDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMS 485 Query: 453 TLLRRFHVKTLQGQCV 468 +R +G+ V Sbjct: 486 IFIRTLKWHYPEGKTV 501 >3QZ1-A nrPDB Length = 496 Score = 62.0 bits (149), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 43/179 (24%), Positives = 84/179 (46%), Gaps = 6/179 (3%) Query: 286 EKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE--- 342 E G L +V+ ++++ I +T + +L + + + HP ++ + +E+ +G Sbjct: 270 EGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEELDRELGPGAS 329 Query: 343 -RDIKIDDIQKLKVMENFIYESMRYQPVVDLVM-RKALEDDVIDGYPVKKGTNIILNIGR 400 + D +L ++ I E +R +PVV L + + I GY + +G +I N+ Sbjct: 330 CSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGMVVIPNLQG 389 Query: 401 MHRLE-FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 H E + +P+EF + F + FG G R C G+ +A + + +L LL+ F Sbjct: 390 AHLDETVWEQPHEFRPDRFLEPGANPSALAFGCGARVCLGESLARLELFVVLARLLQAF 448 >2HI4-A nrPDB Length = 495 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 48/189 (25%), Positives = 87/189 (46%), Gaps = 10/189 (5%) Query: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-ERDIKIDD 349 + +E + + ++ A DT++ ++ + L + P ++ I KE+ TVIG ER ++ D Sbjct: 278 IPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSD 337 Query: 350 IQKLKVMENFIYESMRYQPVVDLVM-RKALEDDVIDGYPVKKGTNIILNIGRM-HRLEFF 407 +L +E FI E+ R+ + + D ++G+ + K + +N ++ H E + Sbjct: 338 RPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELW 397 Query: 408 PKPNEFTLENF------AKNVPY-RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460 P+EF E F A N P FG G R C G+ +A + L LL++ Sbjct: 398 EDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEF 457 Query: 461 KTLQGQCVE 469 G V+ Sbjct: 458 SVPPGVKVD 466 >6AYB-A nrPDB Length = 466 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 64/261 (24%), Positives = 121/261 (46%), Gaps = 19/261 (7%) Query: 229 IKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRR--RISTEEKLEECMDFATELILAE 286 I P FF S K +K+ K + + + L+ ++R + E L+E + +L + Sbjct: 186 ISPLSFFYPSLPAPKRDKARKAVGEIFQELLDKRREEHKKHPERLLDESKMDVVDHLLTQ 245 Query: 287 KRGD---LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-E 342 K D LT + ++ L A T S++ + L + + V E + KE + ++G + Sbjct: 246 KYKDGQELTDVHRIGILIAGLFAGQHTSSITSSWTLMNVISNKKVLEKVRKEQEEIMGSD 305 Query: 343 RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMH 402 + + D + K+ +E + E++R P + ++MR A + + Y + KG ++++ Sbjct: 306 KVLDYDKVMKMDYLEACMKEALRMYPPLIMIMRMARKPRECEQYIIPKGNILVVSPSVAG 365 Query: 403 R-LEFFPKPNEFTLENFAKNVPYRYFQ----PFGFGPRGCAGKYIAMVMMKAILVTLLRR 457 R + + P+ F E + + F+ PFG G C G+ A++ +K+I+ LLR Sbjct: 366 RCTDTYTNPDVFDPERLTERKEHEKFKYGAVPFGAGRHKCIGENFALLQVKSIISILLRY 425 Query: 458 FHVKTLQGQCVESIQKIHDLS 478 F +E I KI D S Sbjct: 426 FD--------MEYIGKIPDPS 438 >6CR2-A nrPDB Length = 477 Score = 59.7 bits (143), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 52/229 (22%), Positives = 97/229 (42%), Gaps = 25/229 (10%) Query: 262 KRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFL 321 K RR + +K E M + + + + E + ++ +L+A + S + +++ Sbjct: 217 KARRQAGSKKDSEDMVWNLMSCVYKNGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLR 276 Query: 322 IAKHPNVEEAIIKEIQTVIGER--DIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALE 379 +A P++ E + +E V+G + D++QKL + I E++R + ++R Sbjct: 277 LATRPDIMEELYQEQIRVLGSDLPPLTYDNLQKLDLHAKVIKETLRLHAPIHSIIRAVKN 336 Query: 380 DDVIDG--YPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKN----------VPYRY 426 +DG Y + N++ + G R E FP P E+ + +N V Y Y Sbjct: 337 PMAVDGTSYVIPTSHNVLSSPGVTARSEEHFPNPLEWNPHRWDENIAASAEDDEKVDYGY 396 Query: 427 ----------FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQG 465 + PFG G C G+ A + + I L+R F + L G Sbjct: 397 GLVSKGTNSPYLPFGAGRHRCIGEQFAYLQLGTITAVLVRLFRFRNLPG 445 >6M7X-A nrPDB Length = 484 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 58/222 (26%), Positives = 102/222 (45%), Gaps = 25/222 (11%) Query: 273 EECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAI 332 ++ EL+L +L+ + + +E+ + DT L LF +A++PNV++A+ Sbjct: 261 QQYTSIVAELLL---NAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQAL 317 Query: 333 IKE---IQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVK 389 +E I E K +L ++ + E++R PV + R A D V+ Y + Sbjct: 318 RQESLAAAASISEHPQKATT--ELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIP 375 Query: 390 KGTNI---ILNIGRMHRLEFFPKPNEFTLENF------AKNVPYRYFQPFGFGPRGCAGK 440 GT + + ++GR L FP+P + + + +N Y PFGFG R C G+ Sbjct: 376 AGTLVRVFLYSLGRNPAL--FPRPERYNPQRWLDIRGSGRNF---YHVPFGFGMRQCLGR 430 Query: 441 YIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPD 482 +A M +L +L+ V+TL E I+ ++ L P Sbjct: 431 RLAEAEMLLLLHHVLKHLQVETL---TQEDIKMVYSFILRPS 469 >3N9Z-A nrPDB Length = 487 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 58/226 (25%), Positives = 104/226 (46%), Gaps = 19/226 (8%) Query: 283 ILAEKRGD--LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVI 340 IL GD ++ E++ + EML DT S++L + L+ +A++ V++ + E V+ Sbjct: 261 ILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAE---VL 317 Query: 341 GERDIKIDD----IQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIIL 396 R D +Q + +++ I E++R P+ + R + D V+ Y + T + + Sbjct: 318 AARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQV 377 Query: 397 NIGRMHR-LEFFPKPNEFTLENF---AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILV 452 I + R FF P F + KN+ Y FG+G R C G+ IA + M L+ Sbjct: 378 AIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLI 437 Query: 453 TLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSD 498 +L F V+ Q + + +L L P++ + F P N + Sbjct: 438 NMLENFRVEI---QHLSDVGTTFNLILMPEKP---ISFTFWPFNQE 477 >5FOI-A nrPDB Length = 408 Score = 55.1 bits (131), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 35/141 (24%), Positives = 65/141 (46%), Gaps = 6/141 (4%) Query: 318 MLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKA 377 +L L A H + + T++ + + ++ ++M N + E +RY + D + R A Sbjct: 242 VLLLAAGHETSANQVTLSVLTLLRHPETAAELREQPELMPNAVDELLRYHSIADGLRRAA 301 Query: 378 LEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLE-NFAKNVPYRYFQPFGFGPRG 436 D V+ + ++ G +I+ + + N F E F + P R+ FG+GP Sbjct: 302 TADIVLGDHTIRAGDGLIILLSSANH-----DGNTFGAEATFDIHRPARHHVAFGYGPHQ 356 Query: 437 CAGKYIAMVMMKAILVTLLRR 457 C G+ +A + M+ L L RR Sbjct: 357 CLGQNLARLEMEVTLGKLFRR 377 >6IQ5-A nrPDB Length = 463 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 44/167 (26%), Positives = 80/167 (47%), Gaps = 11/167 (6%) Query: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-ERDIKIDD 349 L ENV I ++ A+ DT+S +L ++L L ++P+V+ + E+ V+G +R + D Sbjct: 248 LDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGD 307 Query: 350 IQKLKVMENFIYESMRYQPVVDLVMRKALEDDV-IDGYPVKKGTNIILNIGRM-HRLEFF 407 L + F+YE+MR+ V + + A + + GY + K T + +N + H + Sbjct: 308 QPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKW 367 Query: 408 PKPNEFTLENF-------AKNVPYRYFQPFGFGPRGCAGKYIAMVMM 447 P P F F K++ R F G R C G+ ++ + + Sbjct: 368 PNPENFDPARFLDKDGLINKDLTSRVMI-FSVGKRRCIGEELSKMQL 413 >4ZGX-A nrPDB Length = 489 Score = 52.8 bits (125), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 56/217 (25%), Positives = 102/217 (47%), Gaps = 25/217 (11%) Query: 280 TELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKE---I 336 EL+L + +L+ E + +E+ + DT + L LF +A++P+V++ + +E Sbjct: 268 AELLL---KAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAA 324 Query: 337 QTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNI-- 394 I E K +L ++ + E++R PV + R D V+ Y + GT + Sbjct: 325 AASISEHPQKATT--ELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQV 382 Query: 395 -ILNIGRMHRLEFFPKPNEFTLENF------AKNVPYRYFQPFGFGPRGCAGKYIAMVMM 447 + ++GR L FP+P + + + +N + PFGFG R C G+ +A M Sbjct: 383 FLYSLGRNAAL--FPRPERYNPQRWLDIRGSGRNF---HHVPFGFGMRQCLGRRLAEAEM 437 Query: 448 KAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDET 484 +L +L+ F V+TL E I+ ++ L P + Sbjct: 438 LLLLHHVLKHFLVETL---TQEDIKMVYSFILRPGTS 471 >5FSA-A nrPDB Length = 490 Score = 52.0 bits (123), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 44/197 (22%), Positives = 85/197 (43%), Gaps = 32/197 (16%) Query: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGER-----DI 345 +T + + ++ +L+ T + + + L + + P++++ I +E+ ++ E+ D+ Sbjct: 250 MTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDL 309 Query: 346 KIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGTNIILNIGRMHR 403 +D+QKL + N I E++R + + RK I Y V KG ++++ G H Sbjct: 310 TYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHT 369 Query: 404 LE-FFPKPNEFTLE--------------NFAKNVPYRY----------FQPFGFGPRGCA 438 E +F P +F N + V Y + + PFG G C Sbjct: 370 SERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCI 429 Query: 439 GKYIAMVMMKAILVTLL 455 G+ A V + IL T + Sbjct: 430 GEQFAYVQLGTILTTFV 446 >1CPT-A nrPDB Length = 428 Score = 51.2 bits (121), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 34/112 (30%), Positives = 55/112 (49%), Gaps = 6/112 (5%) Query: 355 VMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEF 413 ++ + E++R+ V MR AL D + G +K+G I+L+ +R E F P+EF Sbjct: 299 LIPRLVDEAVRWTAPVKSFMRTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEF 358 Query: 414 TLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQG 465 + F P R+ FG+G C G+++A + MK LL + L G Sbjct: 359 DITRF----PNRHLG-FGWGAHMCLGQHLAKLEMKIFFEELLPKLKSVELSG 405 >6B11-A nrPDB Length = 440 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 45/208 (21%), Positives = 88/208 (42%), Gaps = 30/208 (14%) Query: 252 KDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTM 311 +D ++ LI+ K R S + L ++ + G L+ +V + +L A +T Sbjct: 232 RDYLDRLISGKTGRESGDGML-------GSMVAQARGGGLSHADVLDNAVLLLAAGHETT 284 Query: 312 SVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVD 371 + + + ++ +HP +E+ G ++ + E +RY + D Sbjct: 285 ASMVTMSVLVLLQHPTA----WRELTVNPG-------------LLPGAVDELLRYLSIAD 327 Query: 372 LVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQPF 430 + R A D IDG+ ++ G ++ + +R E F +P F + A R F Sbjct: 328 GLRRSATADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHRSA-----RRHVAF 382 Query: 431 GFGPRGCAGKYIAMVMMKAILVTLLRRF 458 G+GP C G+ +A + ++ L +L R Sbjct: 383 GYGPHQCLGQNLARMELEVALGAVLERL 410 >6A7J-A nrPDB Length = 411 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 59/232 (25%), Positives = 97/232 (41%), Gaps = 45/232 (19%) Query: 265 RISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIA 323 +I E+K D + LI A + GD LT E + L+++IAA ++SL Sbjct: 198 KIVEEKKANPGDDLTSALIAASEDGDHLTDEEILNT-LQLIIAAGHETTISLIV------ 250 Query: 324 KHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVM------ENFIYESMRYQ-PVVDLVMRK 376 NV EA + I Q+ KV+ E I E++R+ P +++R Sbjct: 251 ---NVVEA-------------LAIHPEQRKKVLSGEIPWEGVIEETLRWNTPTSHVLIRF 294 Query: 377 ALEDDVIDGYPVKKGTNIILNIGRMHRLE--FFPKPNEFTLENFAKNVPYRYFQPFGFGP 434 A ED + + KG ++++ G + R E + P +F A P R+ FG GP Sbjct: 295 ATEDIEVGDKVLPKGEGLVVSFGALGRDEEQYGPTAGDFD----ATRTPNRHIA-FGHGP 349 Query: 435 RGCAGKYIAMVMMKAILVTLLRRF-------HVKTLQGQCVESIQKIHDLSL 479 C G ++ + L L RF L+ + + + +HDL + Sbjct: 350 HVCPGAALSRLEAGIALPALYERFPELDLAVPAAELRNKPIVTQNDLHDLPV 401 >3NC3-A nrPDB Length = 441 Score = 49.3 bits (116), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 45/183 (24%), Positives = 83/183 (45%), Gaps = 26/183 (14%) Query: 269 EEKLEECMDFATELILAEKRG-DLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPN 327 E ++ D + L +E G L+ +++ IL +L+AA + +L M++ + +P Sbjct: 231 ERRVNPGSDLISILCTSEYEGMALSDKDILALILNVLLAATEPADKTLALMIYHLLNNP- 289 Query: 328 VEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYP 387 +++ V+ +R + + I E++RY+P V L+ R+ +D V+ G Sbjct: 290 ------EQMNDVLADRSL----------VPRAIAETLRYKPPVQLIPRQLSQDTVVGGME 333 Query: 388 VKKGTNIILNIGRMHR-LEFFPKPNEFTLE------NFAKNVPYRYFQPFGFGPRGCAGK 440 +KK T + IG +R E F +P+ F + A + R+ FG G C G Sbjct: 334 IKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIKSAFSGAARHLA-FGSGIHNCVGT 392 Query: 441 YIA 443 A Sbjct: 393 AFA 395 >3SN5-A nrPDB Length = 491 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 49/196 (25%), Positives = 85/196 (43%), Gaps = 30/196 (15%) Query: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKID-----------D 349 L +L A+ + F+ LF + ++P +A +E++ + K+ + Sbjct: 263 LVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAE 322 Query: 350 IQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI---DG-YPVKKGTNIILNIGRMH-RL 404 + L V+++ I ES+R L +R A ED + DG Y ++K I L MH Sbjct: 323 LNDLPVLDSIIKESLRLS-SASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDP 381 Query: 405 EFFPKPNEFTLENF------AKNVPY-------RYFQPFGFGPRGCAGKYIAMVMMKAIL 451 E +P P F + + K Y Y+ PFG G C G+ A+ +K L Sbjct: 382 EIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFL 441 Query: 452 VTLLRRFHVKTLQGQC 467 + +L F ++ ++GQ Sbjct: 442 ILMLSYFELELIEGQA 457 >3R9C-A nrPDB Length = 418 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 58/232 (25%), Positives = 92/232 (39%), Gaps = 30/232 (12%) Query: 236 KISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTREN 295 + S L+ + K+ L+D + LI E+RR D + L+ E+ GD E+ Sbjct: 193 ETSDLFDEQMKAGMWLRDYLRALIDERRRTPGE--------DLMSGLVAVEESGDQLTED 244 Query: 296 VNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKV 355 +L+ A +V+L + A + ++T + D + V Sbjct: 245 EIIATCNLLLIAGHETTVNL------------IANAALAMLRTPGQWAALAADGSRASAV 292 Query: 356 MENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFT 414 +E E+MRY P V LV R A +D I + V KG ++L + HR P+ F Sbjct: 293 IE----ETMRYDPPVQLVSRYAGDDLTIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFD 348 Query: 415 LENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQ 466 + R+ FG G C G +A + L L RF L G+ Sbjct: 349 PD----RAQIRHLG-FGKGAHFCLGAPLARLEATVALPALAARFPEARLSGE 395 >2RFC-A nrPDB Length = 343 Score = 48.5 bits (114), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 44/151 (29%), Positives = 68/151 (45%), Gaps = 10/151 (6%) Query: 310 TMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRY-QP 368 TM + +++ LI +I + VI E IDD LK F+ E++RY P Sbjct: 174 TMDEKIKYIMLLIIGGNETTTNLIGNMIRVIDENPDIIDD--ALKNRSGFVEETLRYYSP 231 Query: 369 VVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYF 427 + L R A ED I+ +KKG +I+ +G +R E FF +P+ F + ++ Sbjct: 232 IQFLPHRFAAEDSYINNKKIKKGDQVIVYLGSANRDETFFDEPDLFKIGRREMHL----- 286 Query: 428 QPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 FG G C G +A + L +L F Sbjct: 287 -AFGIGIHMCLGAPLARLEASIALNDILNHF 316 >4YZR-A nrPDB Length = 405 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 56/215 (26%), Positives = 92/215 (42%), Gaps = 31/215 (14%) Query: 246 KSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLI 305 +++++ KD I LI + RRI ++ D ++L+ AE+ G E +L +L+ Sbjct: 188 QALREFKDYIAKLIHD--RRIKPKD------DLISKLVHAEENGSKLSEKELYSMLFLLV 239 Query: 306 AAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMR 365 A +V+L L E +K Q+ +++ + E +R Sbjct: 240 VAGLETTVNLLGSGTLALLQHKKECEKLK----------------QQPEMIATAVEELLR 283 Query: 366 Y-QPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVP 423 Y PVV + R A+ED G+ +K+G I + IG +R FF P + P Sbjct: 284 YTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEILNI----NRSP 339 Query: 424 YRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 R+ FGFG C G +A + LL+RF Sbjct: 340 NRHIS-FGFGIHFCLGAPLARLEGHIAFKALLKRF 373 >5XJN-A nrPDB Length = 455 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 42/182 (23%), Positives = 76/182 (41%), Gaps = 23/182 (12%) Query: 277 DFATELILAEKRG-DLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKE 335 + +L+ A++ G ++T + + +L A +T + + ++ HP +AI+ Sbjct: 262 NLTADLVRAQQEGQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAIL-- 319 Query: 336 IQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNII 395 + K++ + E +RY + RKAL+D I G +K+G ++ Sbjct: 320 ---------------ENPKLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVL 364 Query: 396 LNIGRMHRLEF-FPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTL 454 L +G +R E F EF + R FGFG C G +A + K L + Sbjct: 365 LLMGSANRDEARFENGEEFDI----SRANAREHLSFGFGIHYCLGNMLAKLQAKICLEEV 420 Query: 455 LR 456 R Sbjct: 421 TR 422 >5GWE-A nrPDB Length = 405 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 42/182 (23%), Positives = 76/182 (41%), Gaps = 23/182 (12%) Query: 277 DFATELILAEKRG-DLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKE 335 + +L+ A++ G ++T + + +L A +T + + ++ HP +AI+ Sbjct: 212 NLTADLVRAQQEGQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAIL-- 269 Query: 336 IQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNII 395 + K++ + E +RY + RKAL+D I G +K+G ++ Sbjct: 270 ---------------ENPKLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVL 314 Query: 396 LNIGRMHRLEF-FPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTL 454 L +G +R E F EF + R FGFG C G +A + K L + Sbjct: 315 LLMGSANRDEARFENGEEFDI----SRANAREHLSFGFGIHYCLGNMLAKLQAKICLEEV 370 Query: 455 LR 456 R Sbjct: 371 TR 372 >6A7I-A nrPDB Length = 411 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 52/192 (27%), Positives = 82/192 (42%), Gaps = 38/192 (19%) Query: 277 DFATELILAEKRGD-LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKE 335 D + LI A + GD LT E + L+++IAA ++SL NV EA+ Sbjct: 210 DLTSALIAASENGDHLTDEEIVNT-LQLIIAAGHETTISLIV---------NVVEALQTH 259 Query: 336 IQTVIGERDIKIDDIQKLKVM------ENFIYESMRYQ-PVVDLVMRKALEDDVIDGYPV 388 + Q+ KV+ + I E++R+ P +++R A ED + + Sbjct: 260 PE-------------QRKKVLNGEIGWDGVIEETLRWNTPTSHVLIRFATEDIEVGDKIL 306 Query: 389 KKGTNIILNIGRMHRLE--FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVM 446 KG +I++ G + R E + P EF A P R+ FG GP C G ++ + Sbjct: 307 PKGEGLIISFGALGRDEEQYGPTAGEFD----ATRTPNRHIA-FGHGPHVCPGAALSRLE 361 Query: 447 MKAILVTLLRRF 458 L L RF Sbjct: 362 AGIALPALYERF 373 >1WIY-A nrPDB Length = 389 Score = 47.4 bits (111), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 43/188 (22%), Positives = 82/188 (43%), Gaps = 22/188 (11%) Query: 279 ATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQT 338 A LI+ L RE + +L+A +T++ +L + L++ P+ ++ + + + Sbjct: 194 AEALIVHPPLSHLPRERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRVAESEEA 253 Query: 339 VIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYP-VKKGTNIILN 397 + E++R P ++ R+ LE ++ G + +GT ++L+ Sbjct: 254 AL-----------------AAFQEALRLYPPAWILTRR-LERPLLLGEDRLPQGTTLVLS 295 Query: 398 IGRMHRLEFFPKPNEFTLENF--AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLL 455 RL +FP+ F E F + P + PFG G R C G+ A++ +L Sbjct: 296 PYVTQRL-YFPEGEAFQPERFLAERGTPSGRYFPFGLGQRLCLGRDFALLEGPIVLRAFF 354 Query: 456 RRFHVKTL 463 RRF + L Sbjct: 355 RRFRLDPL 362 >5Y1I-A nrPDB Length = 403 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 48/207 (23%), Positives = 88/207 (42%), Gaps = 23/207 (11%) Query: 277 DFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEI 336 D ++L + + G++T+++ + +L A +T + + + ++P Sbjct: 208 DILSDLAVQVEAGEITQDDAAGIGMMLLGAGHETTANMIALGTLALLENP---------- 257 Query: 337 QTVIGERDIKIDDIQKLKVMENFIYESMRYQPVV-DLVMRKALEDDVIDGYPVKKGTNII 395 E+ ++ D KV+ N + E +RY + D V R A ED I G +K G I+ Sbjct: 258 -----EQLAEVRDSDDPKVIVNTVEELLRYLTIAQDTVRRIAAEDIEIGGVVIKAGEGIV 312 Query: 396 LNIGRMH-RLEFFPK-PNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVT 453 + + + +P+ P+ + R FG+G C G +A V ++ + T Sbjct: 313 FPLNAANWDPDLYPEAPDRLDIHRANA----RRHLAFGYGVHQCLGATLARVELQIVYST 368 Query: 454 LLRRFHVKTLQGQCVESIQKIHDLSLH 480 LLRR L G ++ I HD H Sbjct: 369 LLRRIPTLALAG-TLDEIPFKHDQIAH 394 >3ABB-A nrPDB Length = 408 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 39/173 (22%), Positives = 73/173 (42%), Gaps = 23/173 (13%) Query: 287 KRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIK 346 + GDL + V L +L+A +T ++ + +HP + ++++ V G Sbjct: 224 EEGDLDHDEVVMIALVLLVAGHETTVNAIALGALTLIQHPEQIDVLLRDPGAVSG----- 278 Query: 347 IDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LE 405 + E +R+ V D ++R A ED + G +K G ++++I M+R + Sbjct: 279 ------------VVEELLRFTSVSDHIVRMAKEDIEVGGATIKAGDAVLVSITLMNRDAK 326 Query: 406 FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 + P+ F A R+ FG G C G+ +A ++ L L R Sbjct: 327 AYENPDIFDARRNA-----RHHVGFGHGIHQCLGQNLARAELEIALGGLFARI 374 >6F0B-A nrPDB Length = 395 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 30/102 (29%), Positives = 51/102 (50%), Gaps = 7/102 (6%) Query: 359 FIYESMRYQPVVDLVM-RKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLE 416 + E +RY V L + R A ED + G V+ G ++ + +R E FP P+E + Sbjct: 269 LVEELLRYHTVSQLGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFD 328 Query: 417 NFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 +VP+ F G+GP C G+ +A V ++ + ++RR Sbjct: 329 R--PSVPHVGF---GYGPHQCVGQALARVELQEAIPAVIRRL 365 >6FYJ-A nrPDB Length = 421 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 33/114 (28%), Positives = 53/114 (46%), Gaps = 14/114 (12%) Query: 354 KVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNI-GRMHRLEFFPKPNE 412 K + F+ E R+ P V+ +D GY ++GT +L++ G H E + P+ Sbjct: 278 KYSQMFVQEVRRFYPFFPFVVALVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDV 337 Query: 413 FTLENFAKNVPYRYFQPFGFGPRG---------CAGKYIAMVMMKAILVTLLRR 457 F+ + FAK PF F P+G CAG+++ + +MK L L R Sbjct: 338 FSPDRFAK----WEGSPFSFIPQGGGDYFMGHRCAGEWVTIEVMKVSLDYLTNR 387 >5OFQ-A nrPDB Length = 409 Score = 44.7 bits (104), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 37/157 (23%), Positives = 70/157 (44%), Gaps = 6/157 (3%) Query: 316 FFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMR 375 F +L L+A + I ++ + + D++ + + + ++ N + E++RY P + + R Sbjct: 234 FCILLLVAGNETTTNLITNGVRYMTEDVDVQNEVRRDISLVPNLVEETLRYYPPIQAIGR 293 Query: 376 KALEDDVIDGYPVKKGTNIILNIGRMHRLEF-FPKPNEFTLENFAKNVPYRYFQPFGFGP 434 A ED + +K+G +I +R F P+ F + K P+ FGFG Sbjct: 294 IAAEDVELGECKIKRGQQVISWAASANRDSAKFEWPDTFVVHR--KTNPH---VSFGFGI 348 Query: 435 RGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESI 471 C G +A + K LL + +Q Q ++ I Sbjct: 349 HFCLGAPLARMEGKIAFTKLLEKGGFSKVQNQSLKPI 385 >4OQR-A nrPDB Length = 457 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 44/172 (25%), Positives = 73/172 (42%), Gaps = 29/172 (16%) Query: 290 DLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDD 349 DLT E + L +L+A +T + L F + +HP +I + Sbjct: 263 DLTDEELTNIALILLVAGHETTANMLGLGTFALLQHPE------------------QIAN 304 Query: 350 IQKLKVMENFIYESMRYQPVVDLVM--RKALEDDVIDGYPVKKGTNIILNIGRMHR-LEF 406 + +E E +RY +V L R ALED ++G ++KG + + + ++R + Sbjct: 305 LDSPDAVE----ELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKV 360 Query: 407 FPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 F +P+ L+ V R FG G C G+ +A V M+ L RF Sbjct: 361 FDEPDILQLD----RVDARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARF 408 >2ZQJ-A nrPDB Length = 417 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 70/320 (21%), Positives = 129/320 (40%), Gaps = 43/320 (13%) Query: 147 FFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRI 206 F+ ++ P R+ + E K + R E+ + + +L RV + + Sbjct: 98 LFLSLMTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVA-----CYWAGV 152 Query: 207 PLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRR-- 264 PL E+ + + + D D F + + K ++ ++ IEV+I + R Sbjct: 153 PLKETEVKERADDFIDM-------VDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGL 205 Query: 265 -RISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIA 323 + ++ L E M F T+ D ++ + +E++ +++S F + +A Sbjct: 206 LKTTSGTALHE-MAFHTQ-------EDGSQLDSRMAAIELINVLRPIVAISYFLVFSALA 257 Query: 324 KHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI 383 H E KE R+ E F+ E RY P + +D V Sbjct: 258 LH---EHPKYKEWLRSGNSRE-----------REMFVQEVRRYYPFGPFLGALVKKDFVW 303 Query: 384 DGYPVKKGTNIILNI-GRMHRLEFFPKPNEFTLENFA---KNVPYRYFQPFGFGPRG--C 437 + KKGT+++L++ G H + P+EF E FA +N+ Q G +G C Sbjct: 304 NNCEFKKGTSVLLDLYGTNHDPRLWDHPDEFRPERFAEREENLFDMIPQGGGHAEKGHRC 363 Query: 438 AGKYIAMVMMKAILVTLLRR 457 G+ I + +MKA L L+ + Sbjct: 364 PGEGITIEVMKASLDFLVHQ 383 >1LG9-A nrPDB Length = 398 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 40/176 (22%), Positives = 76/176 (43%), Gaps = 20/176 (11%) Query: 283 ILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE 342 ++AE D T E + +++++A D +S + + + +HP +A + Q+ Sbjct: 213 VVAEYGDDATDEELRGFCVQVMLAGDDNISGMIGLGVLAMLRHPEQIDAFRGDEQSA--- 269 Query: 343 RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMH 402 + V E Y ++ Y P R A ED + G +KKG ++I ++ + Sbjct: 270 ---------QRAVDELIRYLTVPYSPTP----RIAREDLTLAGQEIKKGDSVICSLPAAN 316 Query: 403 RLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 R P+ L+ + +P+ FG G C G +A + ++ + L RRF Sbjct: 317 RDPAL-APDVDRLDVTREPIPH---VAFGHGVHHCLGAALARLELRTVFTELWRRF 368 >1EHE-A nrPDB Length = 403 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 47/201 (23%), Positives = 83/201 (41%), Gaps = 32/201 (15%) Query: 266 ISTEEKLEECMDFATELILAE--KRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIA 323 I E++L E D + E K G++ + + Q +L+A TM + + +A Sbjct: 197 ILVEQRLVEPKDDIISKLCTEQVKPGNIDKSDAVQIAFLLLVAGNATMVNMIALGVATLA 256 Query: 324 KHPNVEEAIIKEIQTVIGERDIKIDDIQKLK----VMENFIYESMRYQPVVDLVMRKALE 379 +HP D + +LK + F+ E RY L +++ + Sbjct: 257 QHP---------------------DQLAQLKANPSLAPQFVEELCRYHTASALAIKRTAK 295 Query: 380 DDVIDGYP-VKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGC 437 +DV+ G V+ II + +R E F P+EF N + P + FGFG C Sbjct: 296 EDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEF---NMNRKWPPQDPLGFGFGDHRC 352 Query: 438 AGKYIAMVMMKAILVTLLRRF 458 +++A + + TL ++F Sbjct: 353 IAEHLAKAELTTVFSTLYQKF 373 >4OQS-A nrPDB Length = 433 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 44/172 (25%), Positives = 73/172 (42%), Gaps = 29/172 (16%) Query: 290 DLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDD 349 DLT E + L +L+A +T + L F + +HP E+ +D Sbjct: 224 DLTDEELTNIALLLLVAGHETTANMLGLGTFALLQHP---------------EQIAALDS 268 Query: 350 IQKLKVMENFIYESMRYQPVVDLVM--RKALEDDVIDGYPVKKGTNIILNIGRMHR-LEF 406 + + E +RY +V L R ALED ++G ++KG + + + ++R + Sbjct: 269 -------PDAVEELLRYLSIVHLGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKV 321 Query: 407 FPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 F +P+ L+ V R FG G C G+ +A V M+ L RF Sbjct: 322 FDEPDILQLD----RVDARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARF 369 >5YHJ-A nrPDB Length = 413 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 39/175 (22%), Positives = 81/175 (46%), Gaps = 29/175 (16%) Query: 286 EKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKH--PNVEEAIIKEIQTVIGER 343 ++ G+L E V +E+L T+++S++ + ++A H P+V+E + + Sbjct: 219 DESGELLPEEV--VAVEVLNILRPTVAISVYVLFTVLALHQFPDVKEQVER--------- 267 Query: 344 DIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNI-GRMH 402 ++ K + F+ E R+ P + + D DGY +GT +L++ G H Sbjct: 268 ----GEVSKTE----FVQEVRRFYPFFPVAAARVKTDFEWDGYAFPEGTLTLLDLYGTNH 319 Query: 403 RLEFFPKPNEFTLENFA--KNVPYRYFQPFG----FGPRGCAGKYIAMVMMKAIL 451 + + +P+ F F K P+ + G FG R CAG+++ + ++ ++ Sbjct: 320 DVSIWTEPDRFDPSRFKDWKESPFNFIPQGGGDVDFGHR-CAGEHVTIAILAQVI 373 >2Z36-A nrPDB Length = 413 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 31/100 (31%), Positives = 48/100 (48%), Gaps = 7/100 (7%) Query: 360 IYESMRYQPVVDLVM-RKALEDDVIDGYPVKKGTNIILNIGRMH-RLEFFPKPNEFTLEN 417 + E +RY + D V R A ED I G +K G +I+++ + F P +E Sbjct: 282 VEELLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVER 341 Query: 418 FAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRR 457 A R+ FGFGP C G+ +A + ++ + TL RR Sbjct: 342 GA-----RHHLAFGFGPHQCLGQNLARMELQIVFDTLFRR 376 >3TKT-A nrPDB Length = 450 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 30/113 (26%), Positives = 49/113 (43%), Gaps = 6/113 (5%) Query: 355 VMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILN-IGRMHRLEFFPKPNEF 413 ++ + E++R+ V MR A D + G + G ++LN + H FP+P +F Sbjct: 321 LLPGIVEEAIRWTTPVQHFMRTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKF 380 Query: 414 TLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQ 466 P FG G C G ++A + M+ +L LL R L G+ Sbjct: 381 D-----PTRPANRHLAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGE 428 >5FYF-A nrPDB Length = 470 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 28/108 (25%), Positives = 56/108 (51%), Gaps = 5/108 (4%) Query: 352 KLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEF-FPKP 410 K +++ N + E +R+Q + + R A +D + G +KKG +++ +R E F P Sbjct: 336 KPELIPNMVSEIIRWQTPLAYMRRIAKQDVELGGQTIKKGDRVVMWYASGNRDERKFDNP 395 Query: 411 NEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 ++F ++ K+ R FG+G C G +A + ++ + +L+RF Sbjct: 396 DQFIIDR--KDA--RNHMSFGYGVHRCMGNRLAELQLRILWEEILKRF 439 >3RWL-A nrPDB Length = 426 Score = 41.6 bits (96), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 30/116 (25%), Positives = 57/116 (49%), Gaps = 9/116 (7%) Query: 348 DDIQKLK----VMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR 403 D KLK ++E + E +R+Q + + R A+ D + G ++KG +++ +R Sbjct: 286 DQFAKLKANPALVETMVPEIIRWQTPLAHMRRTAIADSELGGKTIRKGDKVVMWYYSGNR 345 Query: 404 -LEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 E +P EF ++ + P ++ FGFG C G +A + ++ + +L RF Sbjct: 346 DDEVIDRPEEFIID---RPRPRQHLS-FGFGIHRCVGNRLAEMQLRILWEEILTRF 397 >3WEC-A nrPDB Length = 419 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 55/245 (22%), Positives = 96/245 (39%), Gaps = 34/245 (13%) Query: 216 KIQGYFDAWQALLIKP-DIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEE 274 K +G F W L+ DI F I K V D + A + R ++T E Sbjct: 170 KDRGRFSEWSNLVAGVLDINFAIP-------KEVADRRSAAIEESIDYFRTLATSGNAPE 222 Query: 275 CMDFATELILAEKRGD-LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAII 333 + L GD L+ + + L + +A +T S ++ ML ++H + E + Sbjct: 223 GL--VRRLSEVSHGGDQLSVDEIAATCLLITVAGQETTSNTIGNMLITFSRHADQFEQVR 280 Query: 334 KEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTN 393 Q +EN + E +R++P R ALED + G + KG Sbjct: 281 ANPQ-----------------FIENAVAEVLRFEPPAHEAGRIALEDCEVSGANITKGDA 323 Query: 394 IILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVT 453 +++ + +R E + + F++ P +G G C G +A M++ L Sbjct: 324 VMVLLASGNR-EAVERGDTFSVTR-----PDVSSLSYGRGIHHCLGSALANSMLQHFLRE 377 Query: 454 LLRRF 458 L +R+ Sbjct: 378 LSQRY 382 >5L94-A nrPDB Length = 410 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 30/100 (30%), Positives = 47/100 (47%), Gaps = 6/100 (6%) Query: 360 IYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENF 418 I E +RY+ V + R ED + G +K G +++ +G HR E+F P F ++ Sbjct: 279 IEEVLRYRSPVQALHRIVKEDVTLAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFKIDR- 337 Query: 419 AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 NV FG G C G +A + K +L L+ R+ Sbjct: 338 KPNV----HMAFGRGIHFCLGAPLARIEAKIMLAELIDRY 373 >4UBS-A nrPDB Length = 393 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 46/208 (22%), Positives = 81/208 (38%), Gaps = 31/208 (14%) Query: 288 RGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKI 347 RG + R + +LIA +T + + F + +HP + E++ G Sbjct: 214 RGTVDRAELVSLATLLLIAGHETTANMISLGTFTLLRHPEQ----LAELRAEPG------ 263 Query: 348 DDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEF 406 +M + E +R+ + D ++R A ED + G ++ ++ ++R Sbjct: 264 -------LMPAAVEELLRFLSIADGLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAG 316 Query: 407 FPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQ 466 F +P+ A R+ FGFG C G+ +A M+ L TL R L Sbjct: 317 FAEPDALDWHRSA-----RHHVAFGFGIHQCLGQNLARAEMEIALGTLFERLPGLRLAAP 371 Query: 467 CVESIQKIHDLSLHPDET-KNMLEMIFT 493 E + P +T + MLE+ T Sbjct: 372 ADE-------IPFKPGDTIQGMLELPVT 392 >1GWI-A nrPDB Length = 411 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/186 (22%), Positives = 76/186 (40%), Gaps = 25/186 (13%) Query: 277 DFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFL-IAKHPNVEEAIIKE 335 D + LI A + GD + L++++AA ++SL + ++ HP ++ Sbjct: 212 DLTSALIQASENGDHLTDAEIVSTLQLMVAAGHETTISLIVNAVVNLSTHPEQRALVLS- 270 Query: 336 IQTVIGERDIKIDDIQKLKVMENFIYESMRYQ-PVVDLVMRKALEDDVIDGYPVKKGTNI 394 GE + + E++R+ P +++R A ED + + G + Sbjct: 271 -----GEAE-----------WSAVVEETLRFSTPTSHVLIRFAAEDVPVGDRVIPAGDAL 314 Query: 395 ILNIGRMHRLE--FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILV 452 I++ G + R E P + F L + N R+ FG GP C G ++ + L Sbjct: 315 IVSYGALGRDERAHGPTADRFDLTRTSGN---RHIS-FGHGPHVCPGAALSRMEAGVALP 370 Query: 453 TLLRRF 458 L RF Sbjct: 371 ALYARF 376 >3P3Z-A nrPDB Length = 416 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 43/208 (20%), Positives = 82/208 (39%), Gaps = 39/208 (18%) Query: 269 EEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNV 328 + K+E D ++++ A G L + + +L+A +T + L ++ A+HP+ Sbjct: 216 KRKVEPGDDLTSDIVRAFHDGVLDDYELRTLVATVLVAGYETTNHQLALAMYDFAQHPD- 274 Query: 329 EEAIIKEIQTVIGERDIKIDDIQKLKVMEN------FIYESMRYQPVVDL-VMRKALEDD 381 Q +K+ EN + E +R+ P + + R A ED Sbjct: 275 ----------------------QWMKIKENPELAPQAVEEVLRWSPTLPVTATRVAAEDF 312 Query: 382 VIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEF--TLENFAKNVPYRYFQPFGFGPRGCA 438 ++G + GT + + HR F + F T++ A ++ FG GP C Sbjct: 313 EVNGVRIPTGTPVFMCAHVAHRDPRVFADADRFDITVKREAPSI------AFGGGPHFCL 366 Query: 439 GKYIAMVMMKAILVTLLRRFHVKTLQGQ 466 G +A + + + L R + G+ Sbjct: 367 GTALARLELTEAVAALATRLDPPQIAGE 394 >6GK6-A nrPDB Length = 411 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 64/290 (22%), Positives = 122/290 (42%), Gaps = 40/290 (13%) Query: 174 RLEEVTNESGYVDVLTLLRRVML--DTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKP 231 R++E+ + G +D + RR+ L D + L + + + V+ +G F W +L+ P Sbjct: 121 RIQEIAD--GLIDAVIDRRRMELIADFAFPLPTAVIAELLGLPVEDRGRFRRWTKILLAP 178 Query: 232 DIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKR-GD 290 K ++ + V++ L A+ RR+ + D + L+LAE++ Sbjct: 179 ---AKDREFVERAQPVVEEFAAYFRAL-ADARRKAPRD-------DLISGLLLAEEQEHK 227 Query: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDI 350 L+ ++ + +L+A +T + + L+ HP E + E ++G Sbjct: 228 LSPAELSSMVFLLLVAGHETTVHLIASGMLLLLSHP-AERRRLDEDPGLVG--------- 277 Query: 351 QKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFP 408 + + E++R + +L +R +LED + G V G + + +R + FP Sbjct: 278 -------SAVEEALRCEGPAELSTIRWSLEDIELFGARVPAGEGVAAGLLAANRDPQHFP 330 Query: 409 KPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 P+ F + P R+ FG G C G +A + TLLRR Sbjct: 331 DPDRFDI----GRSPNRHIG-FGGGIHFCLGAMLARIEAAIAFSTLLRRL 375 >5D3U-A nrPDB Length = 427 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 29/106 (27%), Positives = 48/106 (45%), Gaps = 9/106 (8%) Query: 356 MENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFT 414 ++N E +RY R A +D + G ++ G + L +G +R F +PN+F Sbjct: 300 VDNTANEVLRYNASNQFTWRVAAKDVEMGGVRIEAGQTLALFLGSANRDANMFERPNDFD 359 Query: 415 LE--NFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 L+ N A+++ FG G C + + +K V LL RF Sbjct: 360 LDRPNSARHLS------FGQGVHACLAAQLISLQLKWFYVALLNRF 399 >5HDI-A nrPDB Length = 404 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 43/178 (24%), Positives = 73/178 (41%), Gaps = 11/178 (6%) Query: 285 AEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGER- 343 A+ R +L E C L DT++ + M+ L A A++ ++ R Sbjct: 210 ADPRDNLLGELATACASGEL----DTLTAQVM-MVTLFAAGGESTAALLGSAVWILATRP 264 Query: 344 DIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR 403 DI+ +++ FI E++RY+P R +DG + ++++L G +R Sbjct: 265 DIQQQVRANPELLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANR 324 Query: 404 LEF-FPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHV 460 F P EF L+ + FG G C G +A + + +L LL R V Sbjct: 325 DPAQFEAPGEFRLDRAGG----KGHISFGKGAHFCVGAALARLEARIVLRLLLDRTSV 378 >5IT1-A nrPDB Length = 399 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 75/175 (42%), Gaps = 15/175 (8%) Query: 293 RENVNQCILEMLIAA--PDTMSVSLFFM----LFLIAKHPNVEEAIIKEIQTVIGERDIK 346 R N ++ LI PD + +F M LIA H + +I ++ +R + Sbjct: 201 RANPGDDLISALITTEDPDGVIDDMFLMNAAGTLLIAAH-DTTACMIGLGTALLLDRPDQ 259 Query: 347 IDDIQK-LKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNI-GRMHR 403 + +QK ++ N + E +RY + R A +D I G + KG ++ ++ Sbjct: 260 LALLQKDPSLIGNAVEELLRYLTIGQFGAERVATQDGEIGGVRIAKGEQVVTHLLSADFD 319 Query: 404 LEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 F P F + + P+ F GFG C G+ +A + ++ + TL RRF Sbjct: 320 PAFVEDPERFDITR--RPAPHLAF---GFGAHQCIGQQLARIELQIVFGTLFRRF 369 >6HQG-A nrPDB Length = 425 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 30/115 (26%), Positives = 53/115 (46%), Gaps = 11/115 (9%) Query: 351 QKLKVMEN------FIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR- 403 Q K+ EN + E++R+Q + + R+A D + G +++G + + +R Sbjct: 284 QDRKLRENPGLIPAMVSETIRWQTPLAYMRRRAKRDFELGGKTIREGDKVAMWYVSGNRD 343 Query: 404 LEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 E +PN++ +E R FGFG C G +A + +K I +L RF Sbjct: 344 EEVIDRPNDYWIERPR----VRQHLSFGFGVHRCVGNRLAELQLKIIWEEILARF 394 >6DCD-A nrPDB Length = 424 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 45/175 (25%), Positives = 73/175 (41%), Gaps = 11/175 (6%) Query: 290 DLTRENVNQCILEMLIAA-PDTMSVSLFFML----FLIAKHPNVEEAIIKEIQTVIGER- 343 D R+ N + + A PD + + ++ FL A ++ V+G+R Sbjct: 213 DRRRQPRNDVLTALATATYPDGSTPEVIDVVRSATFLFAAGQETTAKLLTAAMRVLGDRP 272 Query: 344 DIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR 403 DI+ + ++ NFI ES+R V R A + + G + GT +++ G +R Sbjct: 273 DIQRRLRENRSLIPNFIEESLRMDSPVKSDSRLARKRTTVGGLDIAAGTVVMVLPGAANR 332 Query: 404 -LEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRR 457 F P+EF L+ NV R F G C G +A V + L +L R Sbjct: 333 DPRRFEDPHEFRLDR--PNV--REHMAFARGVHSCPGGPLARVEGRVSLERILDR 383 >3B98-A nrPDB Length = 475 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 40/184 (21%), Positives = 83/184 (45%), Gaps = 28/184 (15%) Query: 300 ILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQK-LKVMEN 358 +L++ + + + + M +L+ HP A+ +EIQ G + +++++ QK V ++ Sbjct: 259 LLQLWVTQGNAGPAAFWVMGYLLT-HPEALRAVREEIQ---GGKHLRLEERQKNTPVFDS 314 Query: 359 FIYESMRYQPVVDLVMRKALEDDVI-----DGYPVKKGTNI-------------ILNIGR 400 ++E++R L+ R +D I Y +++G + I Sbjct: 315 VLWETLRLTAAA-LITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPE 373 Query: 401 MHRLEFFPKPNEFTLENFAKN---VPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRR 457 M + + F + ++F KN V Y P+G C G++ A+ +K ++ T+L R Sbjct: 374 MFQFDRFLNADRTEKKDFFKNGARVKYPSV-PWGTEDNLCPGRHFAVHAIKELVFTILTR 432 Query: 458 FHVK 461 F V+ Sbjct: 433 FDVE 436 >3TYW-A nrPDB Length = 417 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 36/124 (29%), Positives = 56/124 (45%), Gaps = 8/124 (6%) Query: 355 VMENFIYESMRYQPVVDLV-MRKALEDDVIDGYPVKKGTNII-LNIGRMHRLEFFPKPNE 412 +M + E +R V D + +R A ED + G V +I L G H E F P Sbjct: 281 LMPAAVDELLRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPER 340 Query: 413 FTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQ 472 +F + + FG+G C G+++A + ++ L TLLRR L G+ + + Sbjct: 341 V---DFHRT--DNHHVAFGYGVHQCVGQHLARLELEVALETLLRRVPTLRLAGERDQVVV 395 Query: 473 KIHD 476 K HD Sbjct: 396 K-HD 398 >6FSH-A nrPDB Length = 398 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 37/176 (21%), Positives = 76/176 (43%), Gaps = 20/176 (11%) Query: 283 ILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE 342 I+AE +T E + +++++A D +S + + + +HP A+ + Q+ Sbjct: 213 IVAEHGDTITDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQSA--- 269 Query: 343 RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMH 402 D +D++ + Y ++ Y P R A+ED ++ +K+G ++ ++ + Sbjct: 270 -DRAVDELIR--------YLTVPYAPTP----RTAVEDVMVADQVIKEGETVLCSLPMAN 316 Query: 403 RLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 R P+ L+ VP+ FG G C G + + ++ L RRF Sbjct: 317 RDRAL-LPDADRLDVTRTPVPH---VAFGHGIHHCLGAALTRLQLRIAYTALWRRF 368 >3EJB-B nrPDB Length = 404 Score = 38.5 bits (88), Expect = 0.008, Method: Compositional matrix adjust. Identities = 32/114 (28%), Positives = 51/114 (44%), Gaps = 12/114 (10%) Query: 351 QKLKVMEN------FIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR- 403 Q LK+ EN + E +RY+ + R A ED I G +++G + L +G +R Sbjct: 256 QLLKLRENPDLIGTAVEECLRYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRD 315 Query: 404 LEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRR 457 F P+ F + P + FG G C G +A + + + TLL+R Sbjct: 316 PSIFTNPDVFDI----TRSPNPHLS-FGHGHHVCLGSSLARLEAQIAINTLLQR 364 >4TX3-A nrPDB Length = 404 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 37/176 (21%), Positives = 76/176 (43%), Gaps = 20/176 (11%) Query: 283 ILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE 342 I+AE +T E + +++++A D +S + + + +HP A+ + Q+ Sbjct: 219 IVAEHGDTITDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQSA--- 275 Query: 343 RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMH 402 D +D++ + Y ++ Y P R A+ED ++ +K+G ++ ++ + Sbjct: 276 -DRAVDELIR--------YLTVPYAPTP----RTAVEDVMVADQVIKEGETVLCSLPMAN 322 Query: 403 RLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 R P+ L+ VP+ FG G C G + + ++ L RRF Sbjct: 323 RDRAL-LPDADRLDVTRTPVPH---VAFGHGIHHCLGAALTRLQLRIAYTALWRRF 374 >3ABA-A nrPDB Length = 403 Score = 38.1 bits (87), Expect = 0.008, Method: Compositional matrix adjust. Identities = 40/177 (22%), Positives = 76/177 (42%), Gaps = 25/177 (14%) Query: 303 MLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYE 362 +LIAA DT + + L+ P+ + A+++E +++G N + E Sbjct: 234 LLIAAHDTTACMIGLGTALLLDSPD-QLALLREDPSLVG----------------NAVEE 276 Query: 363 SMRYQPVVDLVMRKALEDDV-IDGYPVKKGTNIILNI-GRMHRLEFFPKPNEFTLENFAK 420 +RY + + DV + G + KG ++ ++ F +P F + + Sbjct: 277 LLRYLTIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITR--R 334 Query: 421 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDL 477 P+ F GFG C G+ +A + ++ + TL RR L + VE ++ HD+ Sbjct: 335 PAPHLAF---GFGAHQCIGQQLARIELQIVFETLFRRLPGLRL-AKPVEELRFRHDM 387 >6HQD-A nrPDB Length = 420 Score = 38.1 bits (87), Expect = 0.009, Method: Compositional matrix adjust. Identities = 29/115 (25%), Positives = 53/115 (46%), Gaps = 5/115 (4%) Query: 355 VMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEF 413 ++ + I E +R+Q + + R ALED G ++KG +++ +R E +P +F Sbjct: 291 LLASVIPEVVRWQTPIAHMRRTALEDVEFRGKQIRKGDKVVMWYLSGNRDDEVIDRPMDF 350 Query: 414 TLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCV 468 A R+ FGFG C G +A + +K + + R+ + G+ V Sbjct: 351 ----IADRPRARHHLSFGFGIHRCLGNRLAELQLKILWEEMCERYSRIEVCGEPV 401 >5EX6-C nrPDB Length = 434 Score = 37.7 bits (86), Expect = 0.011, Method: Compositional matrix adjust. Identities = 38/177 (21%), Positives = 74/177 (41%), Gaps = 20/177 (11%) Query: 282 LILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG 341 +++AE +T E + ++M++A D +S + + + ++P A+ ++ Sbjct: 248 MVVAEHGDTVTDEELRGVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAALRGDVPAA-- 305 Query: 342 ERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRM 401 ER V E Y ++ Y P R A+ED + +K G ++ ++ Sbjct: 306 ER----------AVDELIRYLTVPYAPTP----RTAIEDSTVGDQVIKAGETVLCSLPTA 351 Query: 402 HRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 +R P+ L+ + VP+ FG G C G +A + ++ L RRF Sbjct: 352 NRDPAL-LPDADRLDVTREAVPH---VAFGHGVHHCLGAALARLELRIAYTALWRRF 404 >1UED-A nrPDB Length = 406 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 34/105 (32%), Positives = 48/105 (45%), Gaps = 9/105 (8%) Query: 357 ENFIYESMRY-QPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEFT 414 E + E +RY PV R A++D VIDG +K G ++ +I +R E P P+ Sbjct: 279 ERVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDPDVLD 338 Query: 415 LENFA-KNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 A +V FG G C G +A M++ TL RRF Sbjct: 339 ANRAAVSDVG------FGHGIHYCVGAALARSMLRMAYQTLWRRF 377 >2Y5N-A nrPDB Length = 417 Score = 36.6 bits (83), Expect = 0.023, Method: Compositional matrix adjust. Identities = 45/238 (18%), Positives = 101/238 (42%), Gaps = 40/238 (16%) Query: 232 DIFFKISWLY-KKYEKSVKDLKDAIEVLIA------EKRRRISTEEKLEECMDFATELIL 284 D F + S + E + +++++A E A ++RR+ T+ D + L+ Sbjct: 179 DRFTRWSGAFLSTAEVTAEEMQEAAEQAYAYMGDLIDRRRKEPTD-------DLVSALVQ 231 Query: 285 AEKRGD-LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGER 343 A + D L+ + + + +L+A ++ + + ++L+ P + ++ Sbjct: 232 ARDQQDSLSEQELLDLAIGLLVAGYESTTTQIADFVYLLMTRPELRRQLLD--------- 282 Query: 344 DIKIDDIQKLKVMENFIYESMRYQP--VVDLVMRKALEDDVIDGYPVKKGTNIILNIGRM 401 + +++ + + E R+ P V R A+ED + G ++ G ++ + G Sbjct: 283 --------RPELIPSAVEELTRWVPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTGAA 334 Query: 402 HRLEF-FPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 +R + FP + ++ P ++ FG G C G +A V ++ L LL+R Sbjct: 335 NRDQAQFPDADRIDVDR----TPNQHLG-FGHGVHHCLGAPLARVELQVALEVLLQRL 387 >4JBT-A nrPDB Length = 410 Score = 36.6 bits (83), Expect = 0.025, Method: Compositional matrix adjust. Identities = 30/109 (27%), Positives = 51/109 (46%), Gaps = 15/109 (13%) Query: 357 ENFIYESMRYQ-PVVDLVMRKALEDDVIDGYPVKKGTNIILN---IGR---MHRLEFFPK 409 E I E++R+ PV+ L+MR A ED + + +G ++++ IGR +H + Sbjct: 278 ETAIEETLRWDGPVIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGRDITVHGADA--- 334 Query: 410 PNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 ++F + + R+ FG GP C G +A + L L RF Sbjct: 335 -DDF---DITRATAARHIS-FGHGPHICPGAALARLEAAIALPALFTRF 378 >2ZBZ-A nrPDB Length = 412 Score = 36.6 bits (83), Expect = 0.027, Method: Compositional matrix adjust. Identities = 40/178 (22%), Positives = 73/178 (41%), Gaps = 26/178 (14%) Query: 289 GDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKID 348 G++ RE + + +LIA +T + + + HP A+ + V G Sbjct: 227 GEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSLVPGA------ 280 Query: 349 DIQKLKVMENFIYESMRYQPVVDLVM-RKALEDDVIDGYPVKKGTNIILNIGRMHR-LEF 406 + E +RY + D+ R A D ++G ++ G +I+ +R Sbjct: 281 -----------VEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRDGTV 329 Query: 407 FPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQ 464 + P+ + A R+ FGFG C G+ +A + ++ IL L+ R V TL+ Sbjct: 330 YEDPDALDIHRSA-----RHHLAFGFGVHQCLGQNLARLELEVILNALMDR--VPTLR 380 >2WIY-A nrPDB Length = 394 Score = 36.2 bits (82), Expect = 0.032, Method: Compositional matrix adjust. Identities = 29/100 (29%), Positives = 42/100 (42%), Gaps = 4/100 (4%) Query: 360 IYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENF 418 I E +R P +R ED I G ++ G+ I IG +R E F P+ F ++ Sbjct: 270 INEMVRMDPPQLSFLRFPTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVF--DHT 327 Query: 419 AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 R FG GP CAG+ I+ + L R+ Sbjct: 328 RPPAASRNLS-FGLGPHSCAGQIISRAEATTVFAVLAERY 366 >5L1U-A nrPDB Length = 401 Score = 36.2 bits (82), Expect = 0.038, Method: Compositional matrix adjust. Identities = 47/192 (24%), Positives = 80/192 (41%), Gaps = 19/192 (9%) Query: 268 TEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPN 327 +++E D +ELI AEK G L+ ++ +L+ +T V + L+ ++P Sbjct: 198 ARKRVEPGDDILSELI-AEKDGALSDADIAHLGNAVLLFGYETTIVRIDLGTLLLLRNP- 255 Query: 328 VEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYP 387 V+ A + E G +++I +L V L+ R A D + Sbjct: 256 VQRAQLAEDP---GLAPAAVEEILRLGVGGKGSNA---------LIPRYAHGDITVGETV 303 Query: 388 VKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVM 446 ++ G ++L IG + + FP F L V R FG G R C G+ +A + Sbjct: 304 IRTGDAVMLAIGAANYDDRAFPDGGLFDL----TRVRPRSHLAFGHGARHCIGRTLARIE 359 Query: 447 MKAILVTLLRRF 458 + A+ L RR Sbjct: 360 LTAVFERLFRRL 371 >3DBM-A nrPDB Length = 473 Score = 35.4 bits (80), Expect = 0.055, Method: Compositional matrix adjust. Identities = 33/153 (21%), Positives = 71/153 (46%), Gaps = 24/153 (15%) Query: 327 NVEEAIIKEIQTVI---GERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI 383 N+ + +EI+ I G+ ++ ++ I+++ + ++ +YES+R +P V KA + I Sbjct: 298 NLHTQLAEEIRGAIKSYGDGNVTLEAIEQMPLTKSVVYESLRIEPPVPPQYGKAKSNFTI 357 Query: 384 DG----YPVKKGTNII-LNIGRMHRLEFFPKPNEFTLENFAKN----VPYRYFQPFGFGP 434 + + VKKG + + F +P E+ + F + + Y ++ GP Sbjct: 358 ESHDATFEVKKGEMLFGYQPFATKDPKVFDRPEEYVPDRFVGDGEALLKYVWWSN---GP 414 Query: 435 ---------RGCAGKYIAMVMMKAILVTLLRRF 458 + CAGK +++ + ++ L RR+ Sbjct: 415 ETESPTVENKQCAGKDFVVLITRLFVIELFRRY 447 >6G5O-A nrPDB Length = 399 Score = 35.4 bits (80), Expect = 0.055, Method: Compositional matrix adjust. Identities = 40/171 (23%), Positives = 66/171 (38%), Gaps = 29/171 (16%) Query: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDI 350 LT+E V ++ DT+ ++ + +A+HP E + KE + Sbjct: 205 LTKEEVKGVMVLTFAGGRDTVINAVTNSIAYLAEHPEALERLRKEPE------------- 251 Query: 351 QKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPK 409 + + E +RY + + R ED + + VK + I L +R F Sbjct: 252 ----ITGRAVEEMIRYFSPLTQMGRVVTEDTHVCEHAVKADSRISLCWASANRDAAVFEN 307 Query: 410 PNEFTLENFAKNVPYRYFQP---FGFGPRGCAGKYIAMVMMKAILVTLLRR 457 PNE L+ R P FGF C G A ++K +L TL ++ Sbjct: 308 PNEIVLD--------RKVNPHVGFGFSHHNCLGATHARQILKILLQTLAQK 350 >4PWV-A nrPDB Length = 446 Score = 35.4 bits (80), Expect = 0.056, Method: Compositional matrix adjust. Identities = 49/212 (23%), Positives = 87/212 (41%), Gaps = 20/212 (9%) Query: 256 EVLIAEKRRRISTEEKLEECMD----------FATELILAEKRGDLTRENVNQCILEMLI 305 E L+ + +S+E+ + D + +EL+ AE+R T + ++ M+ Sbjct: 193 EFLLKLNKSALSSEDADQSATDAWLARNEILLYFSELV-AERRAKPTEDVISVLANSMVD 251 Query: 306 AAPDTMSVSLFFMLFLIAKHPNVEE-AIIKEIQTVIGERDIKIDDIQKLKV-MENFIYES 363 P T V + LI ++I +QT D + + ++ KV +E+ E Sbjct: 252 GKPLTEEVIVLNCYSLILGGDETSRLSMIDSVQTFTQYPD-QWELLRDGKVTLESATEEV 310 Query: 364 MRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNV 422 +R+ R+A+ D + G + G + L +R E F P F L Sbjct: 311 LRWATPAMHFGRRAVTDMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAFDL----NRS 366 Query: 423 PYRYFQPFGFGPRGCAGKYIAMVMMKAILVTL 454 P ++ FG+GP C G Y+ + A+L L Sbjct: 367 PNKHIT-FGYGPHFCLGAYLGRAEVHALLDAL 397 >3R75-A nrPDB Length = 645 Score = 35.4 bits (80), Expect = 0.056, Method: Compositional matrix adjust. Identities = 18/59 (30%), Positives = 30/59 (50%) Query: 331 AIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVK 389 A I + T +GER IDD +++E I + + + V+++ LE D+ D P K Sbjct: 111 AAIPDADTALGERHFDIDDEAYAEIVERVITDEIGTGAGSNFVIKRTLEGDLDDYSPAK 169 >4XE3-A nrPDB Length = 407 Score = 35.4 bits (80), Expect = 0.066, Method: Compositional matrix adjust. Identities = 38/154 (24%), Positives = 61/154 (39%), Gaps = 19/154 (12%) Query: 311 MSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVV 370 M VSL LIA H I + ++ ER + ++ + E +RY P+V Sbjct: 237 MGVSL-----LIAGHETSVNQITNLVHLLLTERKRYESLVADPALVPAAVEEMLRYTPLV 291 Query: 371 DL--VMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYF 427 +R A ED + V+ G +++ +R E F +E +R Sbjct: 292 SAGSFVRVATEDVELSTVTVRAGEPCVVHFASANRDEEVFDHADELDF--------HRER 343 Query: 428 QP---FGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 P FG G C G + + ++ L L+RRF Sbjct: 344 NPHIAFGHGAHHCIGAQLGRLELQEALSALVRRF 377 >2RCM-A nrPDB Length = 495 Score = 35.0 bits (79), Expect = 0.086, Method: Compositional matrix adjust. Identities = 33/150 (22%), Positives = 70/150 (46%), Gaps = 18/150 (12%) Query: 327 NVEEAIIKEIQTVIGER--DIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVID 384 V + +EI++VI ++ + I+K+++ ++ +YE +R++P V +A +D VI+ Sbjct: 316 QVHNRLAEEIRSVIKSNGGELTMGAIEKMELTKSVVYECLRFEPPVTAQYGRAKKDLVIE 375 Query: 385 ----GYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYFQP--FGFGP--- 434 + VK G + R + F + +EF E F + + + GP Sbjct: 376 SHDAAFKVKAGEMLYGYQPLATRDPKIFDRADEFVPERFVGEEGEKLLRHVLWSNGPETE 435 Query: 435 ------RGCAGKYIAMVMMKAILVTLLRRF 458 + CAGK +++ + ++ + RR+ Sbjct: 436 TPTVGNKQCAGKDFVVLVARLFVIEIFRRY 465 >5DE9-A nrPDB Length = 410 Score = 34.7 bits (78), Expect = 0.10, Method: Compositional matrix adjust. Identities = 30/107 (28%), Positives = 49/107 (45%), Gaps = 8/107 (7%) Query: 354 KVMENFIYESMRYQPVVDLV--MRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKP 410 ++ I E +R+ P + V R ALED I G ++ G + ++ +R E FP P Sbjct: 272 EIRPRAIDELLRWIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDP 331 Query: 411 NEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRR 457 + E P + FGFGP C G +A + + ++ +L R Sbjct: 332 DRIDFER----SPNPHVS-FGFGPHYCPGGMLARLESELLVDAVLDR 373 >2X9P-A nrPDB Length = 404 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 39/173 (22%), Positives = 68/173 (39%), Gaps = 25/173 (14%) Query: 289 GDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKID 348 G+LT + V + +L A D+++ + + L+A HP+ A + + Sbjct: 224 GELTEDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPDQRAAALADPD----------- 272 Query: 349 DIQKLKVMENFIYESMRYQPVVDLVM--RKALEDDVIDGYPVKKGTNIILNIGRMHRLE- 405 VM + E +R V+ R A ED G ++ G ++ ++G + E Sbjct: 273 ------VMARAVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFDER 326 Query: 406 FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 F P EF A P + FG G C G +A + ++ + L R Sbjct: 327 AFTGPEEFD----AARTPNPHLT-FGHGIWHCIGAPLARLELRTMFTKLFTRL 374 >3NV6-A nrPDB Length = 452 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 38/149 (25%), Positives = 65/149 (43%), Gaps = 22/149 (14%) Query: 309 DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQP 368 DT+ L F + +A+HP ++ E+++ LK+M E R P Sbjct: 293 DTVVNFLSFFMIHLARHPE----LVAELRS------------DPLKLMRG-AEEMFRRFP 335 Query: 369 VVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQ 428 VV R +D G +K+G I+L +H L+ P + L+ +++ + Sbjct: 336 VVSEA-RMVAKDQEYKGVFLKRGDMILLPTA-LHGLDDAANPEPWKLDFSRRSISH---S 390 Query: 429 PFGFGPRGCAGKYIAMVMMKAILVTLLRR 457 FG GP CAG ++A + + L L+R Sbjct: 391 TFGGGPHRCAGMHLARMEVIVTLEEWLKR 419 >5XNT-A nrPDB Length = 411 Score = 34.3 bits (77), Expect = 0.13, Method: Compositional matrix adjust. Identities = 30/115 (26%), Positives = 56/115 (48%), Gaps = 6/115 (5%) Query: 351 QKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMH-RLEFFPK 409 + L ++ + E +RY+ + + R ED+ + G +K+G N+++ + + E F Sbjct: 272 ENLDLVPQAVEEMLRYRFNLIKLDRTVKEDNDLLGVELKEGENVVVWMSAANLDEEMFE- 330 Query: 410 PNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF-HVKTL 463 + FTL N + FG GP C G +A + K L T L++F H++ + Sbjct: 331 -DAFTLNIHRPN--NKKHLTFGNGPHFCLGAPLARLEAKIALTTFLKKFKHIEAV 382 >5DQN-A nrPDB Length = 426 Score = 33.1 bits (74), Expect = 0.28, Method: Compositional matrix adjust. Identities = 42/193 (21%), Positives = 76/193 (39%), Gaps = 33/193 (17%) Query: 265 RISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIA 323 +++ E + D T+LI A+ G+ L+ + ++ + +A +T S+ + A Sbjct: 209 KMAEERAVNPTEDIVTKLIEADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITHGMIAFA 268 Query: 324 KHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI 383 ++P+ E KE + E +R+ V R ALED + Sbjct: 269 QNPDQWELYKKERPETAAD-------------------EIVRWATPVSAFQRTALEDVEL 309 Query: 384 DGYPVKKGTNIILNIGRMH-RLEFFPKPNEFTLENFAKNVPYRYFQP-FGFGPRG---CA 438 G +KKG ++++ + E F P+ F + R P GFG G C Sbjct: 310 GGVQIKKGQRVVMSYRSANFDEEVFEDPHTFNI--------LRSPNPHVGFGGTGAHYCI 361 Query: 439 GKYIAMVMMKAIL 451 G +A + + I Sbjct: 362 GANLARMTINLIF 374 >5CJE-A nrPDB Length = 393 Score = 32.7 bits (73), Expect = 0.43, Method: Compositional matrix adjust. Identities = 33/149 (22%), Positives = 59/149 (39%), Gaps = 7/149 (4%) Query: 319 LFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQ-PVVDLVMRKA 377 + L+A H I + T++ D + +++ + E +R++ PV R A Sbjct: 229 ILLVAGHETTVNLITNGVHTLLTHPDQLAALRADMTLLDGAVEEVLRFEGPVETATYRYA 288 Query: 378 LEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRG 436 E I G + +G +++ + R P P+ F + P + FG G Sbjct: 289 AESMEIGGTAIAEGDPVMIGLDAAGRDPARHPDPHVFDI----HRAPQGHLA-FGHGIHY 343 Query: 437 CAGKYIAMVMMKAILVTLLRRFHVKTLQG 465 C G +A + + L +LL R L G Sbjct: 344 CLGAPLARLEARVALRSLLERCPDLALDG 372 >4TRI-A nrPDB Length = 407 Score = 32.7 bits (73), Expect = 0.43, Method: Compositional matrix adjust. Identities = 32/142 (22%), Positives = 59/142 (41%), Gaps = 6/142 (4%) Query: 318 MLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKA 377 +L LI + + ++ RD + + ++ I E +R+ V + R Sbjct: 228 LLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADVDLLPGAIEEMLRWTSPVKNMCRTL 287 Query: 378 LEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQPFGFGPRG 436 D V G ++ G I+L + E F P+ F ++ +N P + FGFG Sbjct: 288 TADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNFRID---RN-PNSHVA-FGFGTHF 342 Query: 437 CAGKYIAMVMMKAILVTLLRRF 458 C G +A + ++ + +LRR Sbjct: 343 CLGNQLARLELRLMTERVLRRL 364 >3WVS-A nrPDB Length = 401 Score = 32.3 bits (72), Expect = 0.46, Method: Compositional matrix adjust. Identities = 25/95 (26%), Positives = 39/95 (41%), Gaps = 6/95 (6%) Query: 375 RKALEDDVIDGYPVKKGTNIILNIGRMHRLEF-FPKPNEFTLENFAKNVPYRYFQPFGFG 433 R A ED + G V+ G +++ +G +R F P E L+ P + FG G Sbjct: 295 RYAREDIEVGGTLVRAGEPVLVALGAANRDGLRFEDPEEIKLDR-----PSNHHIGFGHG 349 Query: 434 PRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCV 468 C G +A + ++ L LL R + G Sbjct: 350 IHHCLGAPLARLELQEALRALLERLPTLKVAGDIA 384 >5JVP-A nrPDB Length = 90 Score = 32.0 bits (71), Expect = 0.63, Method: Composition-based stats. Identities = 24/73 (32%), Positives = 38/73 (52%), Gaps = 8/73 (10%) Query: 240 LYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDF------ATELILAEKRGDLTR 293 L K+Y K + DLK +E + E R + +++LE+ DF ELI E G+ Sbjct: 11 LLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLEKERDFYFGKLRNIELICQENEGE--N 68 Query: 294 ENVNQCILEMLIA 306 + V Q I+++L A Sbjct: 69 DPVLQRIVDILYA 81 >6HQW-A nrPDB Length = 445 Score = 32.0 bits (71), Expect = 0.66, Method: Compositional matrix adjust. Identities = 39/205 (19%), Positives = 84/205 (40%), Gaps = 26/205 (12%) Query: 277 DFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEI 336 D + +I +E ++ + ++ +++ DT ++ ++ + K P+ E + Sbjct: 254 DLISMMIHSEAMNHMSPQEFMGNLVLLIVGGNDTTRNTMSGIVHALDKFPDQRELL---- 309 Query: 337 QTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIIL 396 ERD + + N + E +RY + + R A D + G +K G +IL Sbjct: 310 -----ERDASL--------IPNAVQECIRYVTPLAHMRRTATADTELFGNQIKAGEKVIL 356 Query: 397 NIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLL 455 +R E F P++ ++ N R FG G C G +A + ++ LL Sbjct: 357 WYISANRDETVFENPDKLMVDR--PNA--RRHLSFGHGIHRCVGARLAELQLR----ILL 408 Query: 456 RRFHVKTLQGQCVESIQKIHDLSLH 480 H + ++ + ++++ +H Sbjct: 409 EEMHERRMRVRVAGEVERVRANFVH 433 >6M7L-A nrPDB Length = 404 Score = 31.6 bits (70), Expect = 0.79, Method: Compositional matrix adjust. Identities = 28/109 (25%), Positives = 47/109 (43%), Gaps = 8/109 (7%) Query: 351 QKLKVMENFIYESMRYQPVVD-LVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPK 409 ++ ++ E + E +RY V + L R A ED I G +KKG + ++ +R Sbjct: 272 ERPELGEQAVEEIVRYLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAANR------ 325 Query: 410 PNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 + L+ F FG G C G +A + ++ TL+ RF Sbjct: 326 -ADPALDGFDITRKESRHVAFGHGIHHCLGAPLARMELRIAFTTLVSRF 373 >5OMS-A nrPDB Length = 409 Score = 31.6 bits (70), Expect = 0.79, Method: Compositional matrix adjust. Identities = 26/98 (26%), Positives = 41/98 (41%), Gaps = 7/98 (7%) Query: 360 IYESMRY-QPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRM-HRLEFFPKPNEFTLEN 417 I E +R+ P+ R + + I G + GT ++L+ G H + P+++ L Sbjct: 284 IAEGLRWTSPIWSATARISTKPVTIAGVDLPAGTPVMLSYGSANHDTGKYEAPSQYDLHR 343 Query: 418 FAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLL 455 P FG G CAG Y A +M+ L L Sbjct: 344 -----PPLPHLAFGAGNHACAGIYFANHVMRIALEELF 376 >4MM0-A nrPDB Length = 399 Score = 31.6 bits (70), Expect = 0.80, Method: Compositional matrix adjust. Identities = 40/177 (22%), Positives = 68/177 (38%), Gaps = 19/177 (10%) Query: 293 RENVNQCILEMLIAAP---------DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGER 343 REN +L L+A D S+SL + L+A + + + T++ Sbjct: 200 RENPGSDLLSALVATAAEDNELTDHDVRSLSL---ILLLAGYEPASNQLGSSVLTLLRFP 256 Query: 344 DIKIDDIQKLKVMENFIYESMRYQPVVD-LVMRKALEDDVIDGYPVKKGTNIILNIGRMH 402 D + + ++ + + E MRY P D + R LED I + + ++ + + Sbjct: 257 DRLAELRRDPGLLPSAVEELMRYAPAGDGALFRVTLEDVTIGDTHIPANSAVLASTQAAN 316 Query: 403 -RLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 F P L+ P G G C G +A V ++ + LLRRF Sbjct: 317 WDPRRFDDPTGLRLDR-----PDNQHTALGHGIHFCLGAALARVELQVAIGALLRRF 368 >1UE8-A nrPDB Length = 367 Score = 31.6 bits (70), Expect = 0.86, Method: Compositional matrix adjust. Identities = 53/227 (23%), Positives = 90/227 (39%), Gaps = 30/227 (13%) Query: 246 KSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRG---DLTRENVNQCILE 302 K VKD D + + + S K E + F+ + + + K DLT + N + E Sbjct: 138 KKVKDWSDLVALRLGRADEIFSIGRKYLELISFSKKELDSRKGKEIVDLTGKIANSNLSE 197 Query: 303 MLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQ--TVIGERDIKIDDIQKLKVMENFI 360 + +F+L +IA + I I+ T+ D + + LK +E Sbjct: 198 LEKEG--------YFILLMIAGNETTTNLIGNAIEDFTLYNSWDY-VREKGALKAVE--- 245 Query: 361 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFA 419 E++R+ P V +R E I + +G + + I +R E F P+ F Sbjct: 246 -EALRFSPPVMRTIRVTKEKVKIRDQVIDEGELVRVWIASANRDEEVFKDPDSF------ 298 Query: 420 KNVPYRYFQP---FGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTL 463 +P R P FG G C G +A + + L ++F VK + Sbjct: 299 --IPDRTPNPHLSFGSGIHLCLGAPLARLEARIALEEFAKKFRVKEI 343 >4YT3-A nrPDB Length = 410 Score = 31.6 bits (70), Expect = 0.86, Method: Compositional matrix adjust. Identities = 29/116 (25%), Positives = 55/116 (47%), Gaps = 8/116 (6%) Query: 351 QKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNII--LNIGRMHRLEFFP 408 + L ++ + E +R++ + + R ED+ + G +K+G +++ ++ M E F Sbjct: 272 ENLDLVPQAVEEMLRFRFNLIKLDRTVKEDNDLLGVELKEGDSVVVWMSAANMDE-EMFE 330 Query: 409 KPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF-HVKTL 463 P FTL N + FG GP C G +A + K L L++F H++ + Sbjct: 331 DP--FTLNIHRPN--NKKHLTFGNGPHFCLGAPLARLEAKIALTAFLKKFKHIEAV 382 >4Z5P-A nrPDB Length = 400 Score = 31.2 bits (69), Expect = 0.96, Method: Compositional matrix adjust. Identities = 42/184 (22%), Positives = 81/184 (44%), Gaps = 32/184 (17%) Query: 283 ILAEKRGDLTRENVNQCI---LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTV 339 +L R D R ++ I + +L+A +T + L M++ + H + + ++++E Sbjct: 211 VLVSARDDDDRLTEDELITFGVTLLVAGHETSAHQLGNMVYALLTHED-QLSLLRE---- 265 Query: 340 IGERDIKIDDIQKLKVMENFIYESMRYQPVVDLV--MRKALEDDVIDGYPVKKGTNII-- 395 + +++ + E +R+ P+ + V R ALED + G V+ G ++ Sbjct: 266 ------------QPELLPRAVEELLRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAA 313 Query: 396 -LNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTL 454 +N R R F P+ + KN P+ FG G C G +A + ++ + L Sbjct: 314 AVNANRDPRA--FDDPDRLDITR-EKN-PH---LAFGHGAHYCLGAQLARMELRVAIGGL 366 Query: 455 LRRF 458 L RF Sbjct: 367 LERF 370 >4Z5Q-A nrPDB Length = 423 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 39/174 (22%), Positives = 72/174 (41%), Gaps = 11/174 (6%) Query: 285 AEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERD 344 AE R DLT + +A P+ + + + LI I + + R+ Sbjct: 228 AEPRDDLTSALIEARDAHDRLAEPELIGLCISI---LIGGFETTASEISSFVHVLQQRRE 284 Query: 345 IKIDDIQKLKVMENFIYESMRYQPVV--DLVMRKALEDDVIDGYPVKKGTNIILNIGRMH 402 + + + + E +R+ P + R ALED + G V++G +I++ ++ Sbjct: 285 LWTRLCADPEAIPAAVEELLRFVPFAANGISPRYALEDMTVGGVLVREGEPVIVDTSAVN 344 Query: 403 RLEF-FPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLL 455 R F +E ++ A N R+ FG G C G ++A V ++ L L+ Sbjct: 345 RDGLVFDNADEVVIDR-ADN---RHMV-FGHGAHHCLGAHLARVELQEALKALV 393 >6GII-A nrPDB Length = 479 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 30/157 (19%), Positives = 64/157 (40%), Gaps = 12/157 (7%) Query: 308 PDTMSVSLFFMLF---LIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESM 364 PD ++ S + ++A H A ++T++ + + ++ E + Sbjct: 290 PDVVTDSYLHSMMQAIIVAAHETTVFATTNALKTLLEHETVWREICADPSLIPAAAEECL 349 Query: 365 RYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRM-HRLEFFPKPNEFTL--ENFAKN 421 RY V R+ + ++G + G NI++ + H F P F + N +++ Sbjct: 350 RYNGPVAGWRRRTTREVEVEGVRLPVGANILMVVASANHDSAHFDDPEFFDIGRSNASEH 409 Query: 422 VPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 + FG+G C G+ + + M+ ++ L RR Sbjct: 410 LN------FGYGAHQCLGRNLGRMEMQIMIEELSRRL 440 >3A7C-A nrPDB Length = 580 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 16/48 (33%), Positives = 28/48 (58%) Query: 455 LRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLE 502 ++ ++ Q Q ++SI+ IH L+LH E+ +LE+ +S R LE Sbjct: 181 IKALSLRNYQSQSLKSIRDIHHLTLHLSESAFLLEIFADILSSVRYLE 228 >1F4U-A nrPDB Length = 368 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 28/113 (24%), Positives = 49/113 (43%), Gaps = 11/113 (9%) Query: 360 IYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFA 419 I E++RY P V +RK E + +++G + + I +R +E + Sbjct: 244 IEEALRYSPPVMRTVRKTKERVKLGDQTIEEGEYVRVWIASANR-------DEEVFHDGE 296 Query: 420 KNVPYRYFQP---FGFGPRGCAGKYIAMVMMKAILVTLLRRF-HVKTLQGQCV 468 K +P R P FG G C G +A + + + +RF H++ L + V Sbjct: 297 KFIPDRNPNPHLSFGSGIHLCLGAPLARLEARIAIEEFSKRFRHIEILDTEKV 349 >1ODO-A nrPDB Length = 408 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 54/246 (21%), Positives = 103/246 (41%), Gaps = 36/246 (14%) Query: 218 QGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMD 277 Q D ++AL+ D F + + + + L + ++ LIA KR D Sbjct: 161 QDRRDGFRALV---DGVFDTTLDQAEAQANTARLYEVLDQLIAAKRATPG---------D 208 Query: 278 FATELILAEK--RGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKE 335 T L++A + GD R +P+ + +L M+ A + I + Sbjct: 209 DMTSLLIAARDDEGDGDR------------LSPEELRDTLLLMIS--AGYETTVNVIDQA 254 Query: 336 IQTVIGERDIKIDDIQKLKVM-ENFIYESMRYQPVVD-LVMRKALEDDVI-DGYPVKKGT 392 + T++ D ++ ++K +V + + E++R++P V L +R A+ D + DG + +G Sbjct: 255 VHTLLTRPD-QLALVRKGEVTWADVVEETLRHEPAVKHLPLRYAVTDIALPDGRTIARGE 313 Query: 393 NIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILV 452 I+ + +R P +E + F + FG G C G +A + + L Sbjct: 314 PILASYAAANR---HPDWHE-DADTFDATRTVKEHLAFGHGVHFCLGAPLARMEVTLALE 369 Query: 453 TLLRRF 458 +L RF Sbjct: 370 SLFGRF 375 >5D3I-A nrPDB Length = 568 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 16/48 (33%), Positives = 28/48 (58%) Query: 455 LRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLE 502 ++ ++ Q Q ++SI+ IH L+LH E+ +LE+ +S R LE Sbjct: 159 IKALSLRNYQSQSLKSIRDIHHLTLHLSESAFLLEIFADILSSVRYLE 206 >1Q5D-A nrPDB Length = 419 Score = 30.4 bits (67), Expect = 2.1, Method: Compositional matrix adjust. Identities = 46/204 (22%), Positives = 84/204 (41%), Gaps = 33/204 (16%) Query: 259 IAEKRRRISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAAPDTMSVSLFF 317 + ++RRR E D T L+ AE G L+ + + + ++ A DT + F Sbjct: 212 VLDERRRNPLEN------DVLTMLLQAEADGSRLSTKELVALVGAIIAAGTDTTIYLIAF 265 Query: 318 MLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDL-VMRK 376 + + + P E + E +M N + E +R+ ++ + +R Sbjct: 266 AVLNLLRSPEALELVKAEP-----------------GLMRNALDEVLRFDNILRIGTVRF 308 Query: 377 ALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLE-NFAKNVPYRYFQPFGFGP 434 A +D G +KKG + L I R F +P+ F + + + ++ Y G GP Sbjct: 309 ARQDLEYCGASIKKGEMVFLLIPSALRDGTVFSRPDVFDVRRDTSASLAY------GRGP 362 Query: 435 RGCAGKYIAMVMMKAILVTLLRRF 458 C G +A + + + T+ RRF Sbjct: 363 HVCPGVSLARLEAEIAVGTIFRRF 386 >5OQL-V nrPDB Length = 127 Score = 30.0 bits (66), Expect = 2.2, Method: Composition-based stats. Identities = 17/59 (28%), Positives = 33/59 (55%) Query: 270 EKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNV 328 ++L +C+ A+ +K + T ++VN+ E++I A DT +S+ + LI + NV Sbjct: 19 QELLDCVQQASHYRQLKKGANETTKSVNRGTSELVILAADTQPLSIVLHIPLICEEKNV 77 >5EX8-A nrPDB Length = 424 Score = 30.0 bits (66), Expect = 2.5, Method: Compositional matrix adjust. Identities = 68/355 (19%), Positives = 131/355 (36%), Gaps = 63/355 (17%) Query: 113 SSRFGSKL--GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKT 170 S +F ++L G G+ G + +P R + A S + + + ++ Sbjct: 96 SDKFSARLLYGGTAAGITWPGFLTQYDPPEHTRLRRMVVPAFSHRRMQKFRPRVEQIVQD 155 Query: 171 HLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIK 230 LD +E + G VD + + + FL IP D+ A + +I Sbjct: 156 SLDTIESL---GGPVDFVPHFGWAIATPATCDFLGIPRDDQADLARI------------- 199 Query: 231 PDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD 290 L + ++S K A + ++ ++ + F I+ + GD Sbjct: 200 --------LLASRTDRSDKRRTAAGNKFMTYMKQHVAQSRRGSGDDLFG---IVGRENGD 248 Query: 291 -LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDD 349 +T + ++ AA D ++ L +L+ + P + A+++E Sbjct: 249 AITDAELTGVAAFVMGAAADQVARLLAAGAWLMVEQP-AQFALLRE-------------- 293 Query: 350 IQKLKVMENFIYESMRYQPVVDLVM-RKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFP 408 K + + ++ E+MRY + R A +D I VK G + ++ +R + Sbjct: 294 --KPETVPEWLDETMRYLTTDEKTHPRVATQDVRIGNQLVKAGDTVTCSLLAANRPNYPS 351 Query: 409 KPNEFTL-----ENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 +EF + E+ A FG G C G+ +A +M K + L RF Sbjct: 352 AEDEFDITREKAEHLA----------FGHGIHHCLGRAMAELMFKVSIPALAHRF 396 >2VA8-A nrPDB Length = 715 Score = 28.9 bits (63), Expect = 4.8, Method: Compositional matrix adjust. Identities = 21/77 (27%), Positives = 32/77 (41%), Gaps = 19/77 (24%) Query: 354 KVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEF 413 K +ENF YES+ + +VD+ +A+ + + ++G N F Sbjct: 453 KQLENFAYESLLAKQLVDVYFDRAIRWLLEHSFIKEEG-------------------NTF 493 Query: 414 TLENFAKNVPYRYFQPF 430 L NF K V Y PF Sbjct: 494 ALTNFGKRVADLYINPF 510 >5KYO-A nrPDB Length = 430 Score = 28.9 bits (63), Expect = 5.0, Method: Compositional matrix adjust. Identities = 51/228 (22%), Positives = 87/228 (38%), Gaps = 44/228 (19%) Query: 236 KISWLYKKYEKSVKDLK-DAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRG----D 290 K+ L +Y + + D + E R + +++ D + +I E G D Sbjct: 198 KLKHLADQYTRPDGSIPLDDVTKQFREYLRPVIEARRIKPGEDMISRMINGEVGGRPLTD 257 Query: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDI 350 + EN+ CI ++L+ DT+ L F +AK + AI + Sbjct: 258 IEAENI--CI-QVLVGGLDTVVNMLGFTFSHLAKDHALRRAIAADPS------------- 301 Query: 351 QKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNII-------LNIGRMHR 403 ++++ + E R PVV R+ L D +G +K G ++ ++ R Sbjct: 302 ----LIDDALLEFFRRFPVVSSA-REVLRDQEFEGVLLKAGDMVMAPTVVVAMDDARNE- 355 Query: 404 LEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAIL 451 P EF L A R FG G C G ++A + MK +L Sbjct: 356 -----DPLEFRLGRKA-----RQHSTFGKGSHTCPGAHLARMEMKVVL 393 >1TQY-B nrPDB Length = 415 Score = 28.9 bits (63), Expect = 5.1, Method: Compositional matrix adjust. Identities = 13/52 (25%), Positives = 28/52 (53%), Gaps = 2/52 (3%) Query: 68 MGI--GSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFG 117 MG+ +AC ++ + EF ++W G +++ + +S + F+ + S R G Sbjct: 106 MGVVTANACGGFDFTHREFRKLWSEGPKSVSVYESFAWFYAVNTGQISIRHG 157 >2PFY-A nrPDB Length = 301 Score = 28.9 bits (63), Expect = 6.0, Method: Compositional matrix adjust. Identities = 11/25 (44%), Positives = 15/25 (60%) Query: 134 FNNNPELWKTTRPFFMKALSGPGLV 158 FN + +LWK TRP + L G+V Sbjct: 89 FNESEKLWKATRPLLAQRLDKQGIV 113 >5H1Z-A nrPDB Length = 407 Score = 28.1 bits (61), Expect = 9.5, Method: Compositional matrix adjust. Identities = 47/233 (20%), Positives = 87/233 (37%), Gaps = 20/233 (8%) Query: 233 IFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLT 292 I F W ++ D IE L+ + R+ + EC + L A+ T Sbjct: 156 ILFDFPWEERRKLTFWSDWAGDIE-LVKNEELRLERLRHMYECGGYFQNLWNAKIGKPPT 214 Query: 293 RENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQK 352 + ++ I +A D M +L ++ + + V D+ D K Sbjct: 215 PDLISMMIHSDAMAEMDQMEFLGNLILLIVGGNDTTRNTM----SAVAYGLDLFPDQRAK 270 Query: 353 LK----VMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFP 408 L+ ++ N + E +R+Q + + R A D ++G +K G + L +R Sbjct: 271 LEADPSMIPNTVQEIIRWQTPLAHMRRTATVDSELEGQQIKAGDKLALWYISANR----- 325 Query: 409 KPNEFTLENFAKNV----PYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRR 457 +E EN + + R FG G C G +A + + +L + +R Sbjct: 326 --DESVFENADRIIVDRPNARRHLAFGHGIHRCVGARLAELQIAVLLEEMAKR 376 >5YSW-A nrPDB Length = 441 Score = 28.1 bits (61), Expect = 9.9, Method: Compositional matrix adjust. Identities = 39/158 (24%), Positives = 71/158 (44%), Gaps = 25/158 (15%) Query: 303 MLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYE 362 +LIA DT + L +F++ + P + A ++ DD ++ + + E Sbjct: 274 LLIAGYDTTASMLGLGIFVLLQRP-AQLATLR-------------DDPSRIA---DAVEE 316 Query: 363 SMRYQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAK 420 +RY VV+ + R A ED G + G+ +++++ +R +P P+ L+ Sbjct: 317 LLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHWPDPD---LDLTRP 373 Query: 421 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 P+ F G G C G+ +A + M+A LLRR Sbjct: 374 RGPHLAF---GHGVHQCLGQQLARMEMQAGYAELLRRL 408 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3S79-A nrPDB 671 0.0 6DA2-A nrPDB 347 5e-96 6B82-A nrPDB 341 5e-94 5VEU-A nrPDB 339 2e-93 4R20-A nrPDB 330 7e-91 5UYS-A nrPDB 330 7e-91 4R1Z-A nrPDB 322 2e-88 3MDV-A nrPDB 302 2e-82 3E6I-A nrPDB 302 2e-82 2NNH-A nrPDB 288 3e-78 5W0C-A nrPDB 288 5e-78 1N6B-A nrPDB 284 6e-77 4GQS-A nrPDB 283 1e-76 5YLW-A nrPDB 278 3e-75 3TBG-A nrPDB 277 9e-75 4H1N-A nrPDB 275 4e-74 5E58-A nrPDB 272 2e-73 5E0E-A nrPDB 269 2e-72 3JUS-A nrPDB 265 3e-71 4WMZ-A nrPDB 263 1e-70 2PG7-A nrPDB 262 2e-70 3K9V-A nrPDB 262 4e-70 6C94-A nrPDB 260 8e-70 3DL9-A nrPDB 260 1e-69 3IBD-A nrPDB 258 3e-69 5JLC-A nrPDB 257 8e-69 5VBU-A nrPDB 254 7e-68 3QZ1-A nrPDB 243 2e-64 6AYB-A nrPDB 243 2e-64 6CR2-A nrPDB 239 2e-63 6DWN-A nrPDB 239 2e-63 3EL3-A nrPDB 239 3e-63 2W0A-A nrPDB 237 9e-63 3MZS-A nrPDB 236 1e-62 2HI4-A nrPDB 235 4e-62 2VE3-A nrPDB 233 1e-61 5FSA-A nrPDB 232 2e-61 3N9Z-A nrPDB 223 1e-58 4KPA-A nrPDB 220 9e-58 6IQ5-A nrPDB 218 6e-57 3R9C-A nrPDB 189 2e-48 5L94-A nrPDB 188 5e-48 5OFQ-A nrPDB 186 2e-47 2ZQJ-A nrPDB 186 2e-47 4UBS-A nrPDB 185 4e-47 4YZR-A nrPDB 176 2e-44 4OQS-A nrPDB 176 2e-44 4OQR-A nrPDB 174 7e-44 6GK6-A nrPDB 173 2e-43 1EHE-A nrPDB 173 2e-43 3WEC-A nrPDB 172 4e-43 5FOI-A nrPDB 170 1e-42 5Y1I-A nrPDB 170 1e-42 6M7X-A nrPDB 169 4e-42 4ZGX-A nrPDB 167 1e-41 2Z36-A nrPDB 166 2e-41 6B11-A nrPDB 166 2e-41 6A7J-A nrPDB 165 4e-41 3ABB-A nrPDB 164 7e-41 5XJN-A nrPDB 163 1e-40 5GWE-A nrPDB 163 1e-40 1LG9-A nrPDB 163 2e-40 3P3Z-A nrPDB 162 3e-40 3NC3-A nrPDB 161 5e-40 6A7I-A nrPDB 160 1e-39 1GWI-A nrPDB 159 3e-39 1CPT-A nrPDB 158 8e-39 3RWL-A nrPDB 154 9e-38 3SN5-A nrPDB 154 1e-37 3TKT-A nrPDB 151 9e-37 6FYJ-A nrPDB 149 2e-36 5FYF-A nrPDB 149 3e-36 6F0B-A nrPDB 144 1e-34 1WIY-A nrPDB 142 3e-34 2RFC-A nrPDB 138 6e-33 5YHJ-A nrPDB 137 1e-32 Sequences not found previously or not previously below threshold: 2WX2-A nrPDB 186 2e-47 3L4D-A nrPDB 184 8e-47 3EJB-B nrPDB 180 1e-45 2X2N-A nrPDB 177 9e-45 4RM4-A nrPDB 174 6e-44 5VWS-A nrPDB 171 4e-43 5EX6-C nrPDB 168 4e-42 4JBT-A nrPDB 166 2e-41 2VZM-A nrPDB 164 5e-41 2Y5N-A nrPDB 164 8e-41 2ZBZ-A nrPDB 164 8e-41 4GGV-A nrPDB 164 9e-41 5XNT-A nrPDB 163 1e-40 3WVS-A nrPDB 161 6e-40 5IT1-A nrPDB 160 1e-39 4YT3-A nrPDB 159 2e-39 4Z5P-A nrPDB 158 4e-39 1Z8P-A nrPDB 158 6e-39 2WIO-A nrPDB 158 6e-39 6GMF-A nrPDB 158 7e-39 4TX3-A nrPDB 157 1e-38 4TRI-A nrPDB 156 2e-38 3ABA-A nrPDB 156 2e-38 2XKR-A nrPDB 155 3e-38 5XW2-A nrPDB 154 9e-38 4WPZ-A nrPDB 154 9e-38 6FSH-A nrPDB 154 1e-37 5CJE-A nrPDB 153 2e-37 6HQG-A nrPDB 152 3e-37 1UED-A nrPDB 152 3e-37 3TYW-A nrPDB 150 1e-36 4MM0-A nrPDB 149 2e-36 6HQD-A nrPDB 148 4e-36 3A50-A nrPDB 148 6e-36 5NWS-A nrPDB 147 9e-36 5LIE-A nrPDB 146 2e-35 3MGX-A nrPDB 146 2e-35 6M7L-A nrPDB 145 5e-35 1Q5D-A nrPDB 144 6e-35 1ODO-A nrPDB 144 1e-34 2WM5-A nrPDB 143 1e-34 3A1L-A nrPDB 143 2e-34 4XE3-A nrPDB 142 2e-34 5YSW-A nrPDB 142 3e-34 4Z5Q-A nrPDB 142 4e-34 5Z9I-A nrPDB 140 2e-33 5L1U-A nrPDB 138 5e-33 2FR7-A nrPDB 138 7e-33 1F4U-A nrPDB 137 7e-33 6HQW-A nrPDB 137 1e-32 5DQN-A nrPDB 137 1e-32 5DE9-A nrPDB 137 1e-32 5HH3-A nrPDB 136 2e-32 6CVC-A nrPDB 136 2e-32 6DCD-A nrPDB 133 2e-31 2UUQ-A nrPDB 132 4e-31 5HDI-A nrPDB 129 2e-30 5HIW-A nrPDB 129 3e-30 5EX8-A nrPDB 128 4e-30 5H1Z-A nrPDB 128 5e-30 3OO3-A nrPDB 128 6e-30 1UE8-A nrPDB 125 6e-29 3IVY-A nrPDB 124 6e-29 2X9P-A nrPDB 124 1e-28 4PWV-A nrPDB 123 1e-28 4DO1-A nrPDB 123 2e-28 5LIV-A nrPDB 122 3e-28 6BLD-A nrPDB 122 4e-28 3BUJ-A nrPDB 122 5e-28 6GII-A nrPDB 121 5e-28 5D3U-A nrPDB 121 9e-28 6F88-A nrPDB 121 9e-28 6G5O-A nrPDB 117 1e-26 2WIY-A nrPDB 117 1e-26 2NZA-A nrPDB 115 5e-26 3OFT-A nrPDB 114 8e-26 3AWQ-A nrPDB 114 1e-25 5M0P-A nrPDB 110 2e-24 6G71-A nrPDB 109 2e-24 4FB2-A nrPDB 105 4e-23 5KYO-A nrPDB 102 3e-22 2IJ7-A nrPDB 99 3e-21 5OMS-A nrPDB 98 1e-20 2QBO-A nrPDB 96 3e-20 2RCM-A nrPDB 94 1e-19 3DBM-A nrPDB 92 7e-19 3NV6-A nrPDB 86 4e-17 3B98-A nrPDB 84 1e-16 4C9K-A nrPDB 84 1e-16 2IAG-A nrPDB 82 5e-16 2YJN-B nrPDB 57 2e-08 4YXC-B nrPDB 32 0.45 1PUJ-A nrPDB 32 0.56 3RP9-A nrPDB 32 0.57 3RFT-A nrPDB 31 1.3 7PCK-A nrPDB 29 6.5 5Y77-A nrPDB 28 9.2 >3S79-A nrPDB Length = 503 Score = 671 bits (1730), Expect = 0.0, Method: Composition-based stats. Identities = 503/503 (100%), Positives = 503/503 (100%) Query: 1 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI 60 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI Sbjct: 1 MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI 60 Query: 61 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL 120 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL Sbjct: 61 SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL 120 Query: 121 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN 180 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN Sbjct: 121 GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN 180 Query: 181 ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL 240 ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL Sbjct: 181 ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL 240 Query: 241 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI 300 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI Sbjct: 241 YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI 300 Query: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI 360 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI Sbjct: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI 360 Query: 361 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK 420 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK Sbjct: 361 YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK 420 Query: 421 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH Sbjct: 421 NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480 Query: 481 PDETKNMLEMIFTPRNSDRCLEH 503 PDETKNMLEMIFTPRNSDRCLEH Sbjct: 481 PDETKNMLEMIFTPRNSDRCLEH 503 >6DA2-A nrPDB Length = 487 Score = 347 bits (891), Expect = 5e-96, Method: Composition-based stats. Identities = 90/459 (19%), Positives = 182/459 (39%), Gaps = 27/459 (5%) Query: 47 IPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHI 106 IPGP +G ++S+ + M Y +V+G + G++ ++ M Sbjct: 18 IPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWG-----FYDGQQPVLAITDPDMIKT 72 Query: 107 MKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAE 166 + S F ++ +G + I + E WK R + L MV + A+ Sbjct: 73 VLVKECYSVFTNRRPFGPVGFMKSAISIAEDEE-WKRLRSLLSPTFTSGKLKEMVPIIAQ 131 Query: 167 SLKTHLDRLEEVTNESGYVDVLTLLRRVMLDT-------SNTLFLRIPLDESAIVVKIQG 219 + L V + + +D N L P D K Sbjct: 132 YGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLL 191 Query: 220 YFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFA 279 FD + +F + + + V + + + KR + S E ++ Sbjct: 192 RFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDF 251 Query: 280 TELILAEKRGD-------LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAI 332 +L++ + L+ + + + A +T S L F+++ +A HP+V++ + Sbjct: 252 LQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKL 311 Query: 333 IKEIQTVIGER-DIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKG 391 +EI V+ + D + +++ ++ + E++R P+ + R +D I+G + KG Sbjct: 312 QEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKG 371 Query: 392 TNIILNIGRMHR-LEFFPKPNEFTLENFAK----NVPYRYFQPFGFGPRGCAGKYIAMVM 446 +++ +HR +++ +P +F E F+K N+ + PFG GPR C G A++ Sbjct: 372 VVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMN 431 Query: 447 MKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETK 485 MK L+ +L+ F K + + + L L P++ Sbjct: 432 MKLALIRVLQNFSFKPCKETQIPLKLSLGGL-LQPEKPV 469 >6B82-A nrPDB Length = 509 Score = 341 bits (874), Expect = 5e-94, Method: Composition-based stats. Identities = 104/473 (21%), Positives = 185/473 (39%), Gaps = 38/473 (8%) Query: 43 GTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYN---RVYGEFMRVWISGEETLIISK 99 G S P IG L+S + ++ + YG+ + + + LI++ Sbjct: 21 GNRSPPSLPSLPIIGSLMS-----LVSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNN 75 Query: 100 SSSMFHIM--KHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALS--GP 155 I+ K ++ R + + K I F + WK R AL G Sbjct: 76 HHHAKEILIKKGKIFAGR-PRTVTTDLLTRDGKDIAFADYSSTWKFHRKMVHGALCMFGE 134 Query: 156 GLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDT-SNTLFLRIPLDESAIV 214 G V + + + + L E N + VD+ L R + + F A Sbjct: 135 GSVSIEKIICREASSMCEVLTESQNSA--VDLGPELTRAVTNVVCALCFNSSYKRGDAEF 192 Query: 215 VKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAI---EVLIAEKRRRISTEEK 271 + Y + K + WL K ++ L+ I + L+ +K Sbjct: 193 ESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKDLRILRQCISIRDKLLQKKYEEHKVTYS 252 Query: 272 LEECMDFATELILAEKRGD----------LTRENVNQCILEMLIAAPDTMSVSLFFMLFL 321 D L+ A++ + LT ++V + E+ A +T + +L + + Sbjct: 253 DNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGAGVETTTTTLKWSIAY 312 Query: 322 IAKHPNVEEAIIKEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDLVM-RKALE 379 + +P V+ I +E+ + IG ER ++ D L +E I E MR +PV L++ AL+ Sbjct: 313 LVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSPLLIPHVALQ 372 Query: 380 DDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKN------VPYRYFQPFGF 432 D + Y V+KGT +++N+ +H E + P F F P + PFG Sbjct: 373 DSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGA 432 Query: 433 GPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETK 485 G R C G+ +A + + L +L+RF ++ GQ + +Q + L P + K Sbjct: 433 GVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPKKFK 485 >5VEU-A nrPDB Length = 480 Score = 339 bits (869), Expect = 2e-93, Method: Composition-based stats. Identities = 95/458 (20%), Positives = 186/458 (40%), Gaps = 28/458 (6%) Query: 47 IPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHI 106 IPGP +G ++S+ + LW Y +++G + G+ ++ + Sbjct: 17 IPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTY-----EGQLPVLAITDPDVIRT 71 Query: 107 MKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAE 166 + S F ++ L +G + I + E WK R + L M + A+ Sbjct: 72 VLVKECYSVFTNRRSLGPVGFMKSAISLAEDEE-WKRIRSLLSPTFTSGKLKEMFPIIAQ 130 Query: 167 SLKTHLDRLEEVTNESGYVDVLTLLRRVMLDT-------SNTLFLRIPLDESAIVVKIQG 219 + L + V + + +D N L P D K Sbjct: 131 YGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFL 190 Query: 220 YFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTE--EKLEECMD 277 F L + +F ++ +++ S+ KD I L R + +K + +D Sbjct: 191 KFGFLDPLFLSIILFPFLTPVFEALNVSLFP-KDTINFLSKSVNRMKKSRLNDKQKHRLD 249 Query: 278 FATELILAEKRGD------LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEA 331 F +I ++ + L+ + + + A +T S L F L+ +A HP+V++ Sbjct: 250 FLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQK 309 Query: 332 IIKEIQTVIGER-DIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKK 390 + KEI V+ + D + +++ ++ + E++R PV + R +D I+G + K Sbjct: 310 LQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPK 369 Query: 391 GTNIILNIGRM-HRLEFFPKPNEFTLENFAK---NVPYRYFQPFGFGPRGCAGKYIAMVM 446 G+ +++ + H +++ +P EF E F+K ++ + PFG GPR C G A++ Sbjct: 370 GSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMN 429 Query: 447 MKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDET 484 MK L+ +L+ F K + + L L P++ Sbjct: 430 MKLALIRVLQNFSFKPCKETQIPLKLDTQGL-LQPEKP 466 >4R20-A nrPDB Length = 486 Score = 330 bits (847), Expect = 7e-91, Method: Composition-based stats. Identities = 93/437 (21%), Positives = 183/437 (41%), Gaps = 25/437 (5%) Query: 78 NRVYGEFMRVWISGEETLIISKSSSMFHIMK--HNHYSSRFGSKLGLQCIGMHEKGIIFN 135 + YG ++ TL++S+ + ++ ++ R + + K I F Sbjct: 49 SSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGR-PKMVTTDLLTQGGKDIAFA 107 Query: 136 NNPELWKTTRPFFMKALS--GPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRR 193 + LWK R + + G G ++ T+ E+ + + L+ +S + V+ L+R Sbjct: 108 DYSPLWKNHRRLVHSSFTLFGEGSNKLQTIVQEAADSLCEELQACRGQSSDLSVV-LMRA 166 Query: 194 VMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKD 253 V +F + + Y D + + + WL K +K LK+ Sbjct: 167 VTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQTIARGGLVDIFPWLRIFPNKDLKRLKE 226 Query: 254 AI---EVLIAEKRRRISTEEKLEECMDFATELILAEKRG-----DLTRENVNQCILEMLI 305 + + L+ +K E D L++ ++RG D+T ++V E Sbjct: 227 CVSIRDQLLYKKLLEHKKSLTPGEPRDLLDALLIGQQRGSGGADDITEDHVLMTAAEAFG 286 Query: 306 AAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-ERDIKIDDIQKLKVMENFIYESM 364 A +T S +L + + + HP ++E + E+ +G +R + D L +++ + E M Sbjct: 287 AGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSDRPHLPLLDAVLCEVM 346 Query: 365 RYQPVVDLVM-RKALEDDVIDGYPVKKGTNIILNIGRMH-RLEFFPKPNEFTLENF---- 418 R +PV +++ A++D + G+ V KGT +++N+ +H + + +P +F E F Sbjct: 347 RIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWDQPEQFNPERFLEPS 406 Query: 419 AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLS 478 K F PFG GPR C G+ +A + + + L+RF + +Q + Sbjct: 407 GKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFSCPSEASLPDLQGRFGVV 466 Query: 479 LHPDETKNMLEMIFTPR 495 L P+ + TPR Sbjct: 467 LQPERY----TVTVTPR 479 >5UYS-A nrPDB Length = 494 Score = 330 bits (846), Expect = 7e-91, Method: Composition-based stats. Identities = 96/468 (20%), Positives = 182/468 (38%), Gaps = 38/468 (8%) Query: 46 SIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFH 105 S+P G + + + YG V + + T+I+ Sbjct: 15 SLPLVGSLPFLPRHGHMHNNFF--------KLQKKYGPIYSVRMGTKTTVIVGHHQLAKE 66 Query: 106 IM--KHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKAL--SGPGLVRMV 161 ++ K +S R L + KGI F ++ W+ R M G ++ Sbjct: 67 VLIKKGKDFSGR-PQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLE 125 Query: 162 TVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYF 221 + + + T D L +S + + V S F + + IQ Y Sbjct: 126 KIICQEISTLCDMLATHNGQSIDIS-FPVFVAVTNVISLICFNTSYKNGDPELNVIQNYN 184 Query: 222 DAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVL------IAEKRRRISTEEKLEEC 275 + L K + + WL K+++ LK +++ I E + + + Sbjct: 185 EGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNM 244 Query: 276 MDFATELILAEKRGD---------LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHP 326 +D + + G+ L+ ++ I ++ A +T + + + L + +P Sbjct: 245 LDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNP 304 Query: 327 NVEEAIIKEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDLVM-RKALEDDVID 384 V++ + +EI +G R I D +L ++E I E +R +PV +++ KA D I Sbjct: 305 QVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIG 364 Query: 385 GYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNV------PYRYFQPFGFGPRGC 437 + V KGT +I+N+ +H E + +P++F E F P + PFG GPR C Sbjct: 365 EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSC 424 Query: 438 AGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETK 485 G+ +A + I+ LL+RF ++ + S++ I + D K Sbjct: 425 IGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFK 472 >4R1Z-A nrPDB Length = 439 Score = 322 bits (826), Expect = 2e-88, Method: Composition-based stats. Identities = 92/424 (21%), Positives = 167/424 (39%), Gaps = 30/424 (7%) Query: 89 ISGEETLIISKSSSMFHIM--KHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRP 146 + + LI++ I+ K ++ R + + K I F + WK R Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGR-PRTVTTDLLTRDGKDIAFADYSSTWKFHRK 59 Query: 147 FFMKALS--GPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDT-SNTLF 203 AL G G V + + + + L E N + VD+ L R + + F Sbjct: 60 MVHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSA--VDLGPELTRAVTNVVCALCF 117 Query: 204 LRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAI---EVLIA 260 A + Y + K + WL K + L+ I + L+ Sbjct: 118 NSSYKRGDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKDLTILRQCISIRDKLLQ 177 Query: 261 EKRRRISTEEKLEECMDFATELILAEKRGD----------LTRENVNQCILEMLIAAPDT 310 +K D L+ A++ + LT ++V + ++ A +T Sbjct: 178 KKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDIFGAGVET 237 Query: 311 MSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPV 369 + L + + + +P V+ I +E+ + IG ER ++ D L +E I E +R +PV Sbjct: 238 TTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIREVLRIRPV 297 Query: 370 VDLVM-RKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKN------ 421 L++ AL+D + Y V+KGT +++N+ +H + + P F F Sbjct: 298 SPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLNEEGDGLC 357 Query: 422 VPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHP 481 P + PFG G R C G+ +A + + L +L+RF ++ GQ + +Q + L P Sbjct: 358 CPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQP 417 Query: 482 DETK 485 + K Sbjct: 418 KKFK 421 >3MDV-A nrPDB Length = 456 Score = 302 bits (774), Expect = 2e-82, Method: Composition-based stats. Identities = 87/419 (20%), Positives = 174/419 (41%), Gaps = 18/419 (4%) Query: 77 YNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCI---GMHEKGII 133 + + YG +RV + + ++I++ S+ + Y+ LQ + + +G++ Sbjct: 19 WAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLV 78 Query: 134 FNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRR 193 N E W R A S LV ++ E + ++ LE + V + +L Sbjct: 79 SECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTY 138 Query: 194 VMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKIS--WLYKKYEKSVKDL 251 +D + E+++++ Q L+++ + + K ++++ Sbjct: 139 TAMDILAKAAFGM---ETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREV 195 Query: 252 KDAIEVLIAE-----KRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIA 306 +++I L +RRR + + E D T+++ AE+ G E + + IA Sbjct: 196 RESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEE-GAQDDEGLLDNFVTFFIA 254 Query: 307 APDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE-RDIKIDDIQKLKVMENFIYESMR 365 +T + L F + +++ P + + E+ VIG R + +D+ +L+ + + ES+R Sbjct: 255 GHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLR 314 Query: 366 YQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPY 424 P R E+ +IDG V T ++ + M R +F P F + F P Sbjct: 315 LYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPK 374 Query: 425 RYFQ--PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHP 481 F PF G R C G+ A + +K ++ LL+R + + GQ ++ L P Sbjct: 375 PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDP 433 >3E6I-A nrPDB Length = 476 Score = 302 bits (773), Expect = 2e-82, Method: Composition-based stats. Identities = 102/454 (22%), Positives = 192/454 (42%), Gaps = 38/454 (8%) Query: 48 PGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIM 107 PGP IG L + I + + +G +++ + +++ ++ + Sbjct: 13 PGPFPLPIIGNLF---QLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEAL 69 Query: 108 KHNHYSSRFGSKLGLQCIGMH-EKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAE 166 Y F + L H ++GIIFNN P WK R F + L G+ + Sbjct: 70 L--DYKDEFSGRGDLPAFHAHRDRGIIFNNGP-TWKDIRRFSLTTLRNYGMGKQGNESRI 126 Query: 167 SLKTHLDRLEEVTNESG------------YVDVL-TLLRRVMLDTSNTLFLRIP--LDES 211 + H LE + G +V+ +L R D ++ FLR+ +E+ Sbjct: 127 QREAHF-LLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNEN 185 Query: 212 AIVVKIQGYFDAWQALLIK-PDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRI--ST 268 ++ W L P + ++K K+V ++K+ + + E + + + Sbjct: 186 FHLLST-----PWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNC 240 Query: 269 EEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNV 328 L +C+ E T + + + ++ A +T S +L + L ++ K+P + Sbjct: 241 PRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEI 300 Query: 329 EEAIIKEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGY 386 EE + +EI VIG R I D Q++ M+ ++E R+ +V + +A D + GY Sbjct: 301 EEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGY 360 Query: 387 PVKKGTNIILNI-GRMHRLEFFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKY 441 + KGT ++ + ++ + FP P +F E+F K YF+PF G R CAG+ Sbjct: 361 LIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEG 420 Query: 442 IAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIH 475 +A + + +L +L+ F++K L + IH Sbjct: 421 LARMELFLLLCAILQHFNLKPLVDPKDIDLSPIH 454 >2NNH-A nrPDB Length = 476 Score = 288 bits (738), Expect = 3e-78, Method: Composition-based stats. Identities = 89/440 (20%), Positives = 165/440 (37%), Gaps = 31/440 (7%) Query: 48 PGPGYCMGIGPLISHGRFLWMGIGSACNYY---NRVYGEFMRVWISGEETLIISKSSSMF 104 PGP IG ++ + + C + ++VYG V+ ++ ++ Sbjct: 13 PGPTPLPIIGNMLQ------IDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVK 66 Query: 105 HIMKHNHYSSRFGSKLGLQCIGMHEKGI-IFNNNPELWKTTRPFFMKALSGPGLVRMVTV 163 + N F + KG+ I ++N + WK R F + L G+ + Sbjct: 67 EALIDN--GEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIE 124 Query: 164 CAESLKTHLDRLEEVTNESGYVD-VLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYF- 221 + H E ++ D L + +F + + + + F Sbjct: 125 DRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFN 184 Query: 222 -------DAWQALLIK-PDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRI--STEEK 271 W + P + + K K+V + I + E + + + Sbjct: 185 ENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRD 244 Query: 272 LEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEA 331 +C E ++ + EN+ + ++ +A +T S +L + L L+ KHP V Sbjct: 245 FIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAK 304 Query: 332 IIKEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYPVK 389 + +EI VIG R + D + + ++E RY +V V D Y + Sbjct: 305 VQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIP 364 Query: 390 KGTNIILNIGR-MHRLEFFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIAM 444 KGT I+ + +H + FP PN F +F YF PF G R CAG+ +A Sbjct: 365 KGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLAR 424 Query: 445 VMMKAILVTLLRRFHVKTLQ 464 + + L T+L+ F++K++ Sbjct: 425 MELFLFLTTILQNFNLKSVD 444 >5W0C-A nrPDB Length = 477 Score = 288 bits (736), Expect = 5e-78, Method: Composition-based stats. Identities = 89/459 (19%), Positives = 184/459 (40%), Gaps = 34/459 (7%) Query: 48 PGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIM 107 PGP IG ++ G I + ++VYG ++ + +++ ++ + Sbjct: 14 PGPTPLPVIGNILQIG---IKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEAL 70 Query: 108 --KHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVR--MVTV 163 +S R L GI+F+N + WK R F + L G+ + + Sbjct: 71 IDLGEEFSGR--GIFPLAERANRGFGIVFSNG-KKWKEIRRFSLMTLRNFGMGKRSIEDR 127 Query: 164 CAESLKTHLDRLEEVTNESG---------YVDVL-TLLRRVMLDTSNTLFLRIPLDESAI 213 E + ++ L + +V+ +++ D + FL + + Sbjct: 128 VQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNEN 187 Query: 214 VVKIQGYFDAWQALLIK-PDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRI--STEE 270 + + W + I + K K+V +K I + E + + + + Sbjct: 188 IKILS---SPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQ 244 Query: 271 KLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEE 330 +C E + + T E++ +++ A +T S +L + L L+ KHP V Sbjct: 245 DFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTA 304 Query: 331 AIIKEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALE-DDVIDGYPV 388 + +EI+ VIG R + D + + ++E RY ++ + A+ D Y + Sbjct: 305 KVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLI 364 Query: 389 KKGTNIILNIGR-MHRLEFFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIA 443 KGT I++++ +H + FP P F +F +YF PF G R C G+ +A Sbjct: 365 PKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALA 424 Query: 444 MVMMKAILVTLLRRFHVKTL-QGQCVESIQKIHDLSLHP 481 + + L ++L+ F++K+L + +++ ++ + P Sbjct: 425 GMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP 463 >1N6B-A nrPDB Length = 473 Score = 284 bits (726), Expect = 6e-77, Method: Composition-based stats. Identities = 84/466 (18%), Positives = 184/466 (39%), Gaps = 30/466 (6%) Query: 48 PGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIM 107 PGP IG ++ + I + ++ YG V++ + T+++ ++ + Sbjct: 13 PGPTPFPIIGNIL---QIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLHGYEAVKEAL 69 Query: 108 KHNHYSSRFGSKLGLQCIGMHEKGIIFN-NNPELWKTTRPFFMKALSGPGLVR--MVTVC 164 F + + + KG+ +N + WK R F + L G+ + + Sbjct: 70 V--DLGEEFAGRGSVPILEKVSKGLGIAFSNAKTWKEMRRFSLMTLRNFGMGKRSIEDRI 127 Query: 165 AESLKTHLDRLEEVTNESG---------YVDVL-TLLRRVMLDTSNTLFLRIPLDESAIV 214 E + ++ L + +V+ +++ D + FL++ ++ Sbjct: 128 QEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKLM---ESLH 184 Query: 215 VKIQGYFDAWQALLIK-PDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLE 273 ++ W + P + ++K K+ +K+ I + E +++ Sbjct: 185 ENVELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEH-QKLLDVNNPR 243 Query: 274 ECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAII 333 + +D + E + T E++ + ++ A +T S +L + L L+ KHP V + Sbjct: 244 DFIDCFLIKMEQENNLEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPEVAARVQ 303 Query: 334 KEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYPVKKG 391 +EI+ VIG R + D ++ + I+E R+ ++ + D Y + KG Sbjct: 304 EEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFRNYFIPKG 363 Query: 392 TNIILNIGR-MHRLEFFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIAMVM 446 T+II ++ +H + FP P F +F YF PF G R C G+ +A + Sbjct: 364 TDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRMCVGEGLARME 423 Query: 447 MKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIF 492 + L ++L+ F +++L I + + + + + + Sbjct: 424 LFLFLTSILQNFKLQSLVEPKDLDITAVVNGFVSVPPSYQLCFIPI 469 >4GQS-A nrPDB Length = 477 Score = 283 bits (724), Expect = 1e-76, Method: Composition-based stats. Identities = 88/469 (18%), Positives = 178/469 (37%), Gaps = 33/469 (7%) Query: 48 PGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIM 107 PGP IG ++ + + + +++YG ++ E +++ + + Sbjct: 14 PGPTPLPVIGNIL---QIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEAL 70 Query: 108 --KHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVR--MVTV 163 +S R L GI+F+N + WK R F + L G+ + + Sbjct: 71 IDLGEEFSGR--GHFPLAERANRGFGIVFSNG-KRWKEIRRFSLMTLRNFGMGKRSIEDR 127 Query: 164 CAESLKTHLDRLEEVTNESG---------YVDVL-TLLRRVMLDTSNTLFLRIPLDESAI 213 E + ++ L + +V+ +++ + D + FL + + Sbjct: 128 VQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNE- 186 Query: 214 VVKIQGYFDAWQALLIK-PDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRR--ISTEE 270 I+ W + P I + K K++ ++ I + E + I+ Sbjct: 187 --NIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPR 244 Query: 271 KLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEE 330 +C E ++ + T EN+ ++L A +T S +L + L L+ KHP V Sbjct: 245 DFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTA 304 Query: 331 AIIKEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALE-DDVIDGYPV 388 + +EI+ V+G R + D + + ++E RY ++ + A+ D Y + Sbjct: 305 KVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLI 364 Query: 389 KKGTNIILNIGR-MHRLEFFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIA 443 KGT I+ ++ +H + FP P F +F YF PF G R C G+ +A Sbjct: 365 PKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLA 424 Query: 444 MVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIF 492 + + L +L+ F++K+L + + + + Sbjct: 425 RMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPI 473 >5YLW-A nrPDB Length = 495 Score = 278 bits (712), Expect = 3e-75, Method: Composition-based stats. Identities = 89/448 (19%), Positives = 178/448 (39%), Gaps = 38/448 (8%) Query: 48 PGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIM 107 PGP +G ++ G ++ YG M + + T+I+S S M + Sbjct: 30 PGPFPYPIVGNMLQLG----ANPHQVFAKLSKRYGPLMSIHLGSLYTVIVS-SPEMAKEI 84 Query: 108 KHNH---YSSRFGSKLGLQCIGMHEK-GIIFNNNPELWKTTRPFFMKAL-SGPGLVRMVT 162 H H +S R ++ C H+K + F W+ R + + S + Sbjct: 85 LHRHGQVFSGRTIAQAVHACD--HDKISMGFLPVASEWRDMRKICKEQMFSNQSMEASQG 142 Query: 163 VCAESLKTHLDRLEEVTN--------ESGYVDVLTLLRRV-------MLDTSNTLFLRIP 207 + + L+ LD +++ ++ E+ ++ L L+ D+ T+ + Sbjct: 143 LRRQKLQQLLDHVQKCSDSGRAVDIREAAFITTLNLMSATLFSSQATEFDSKATMEFKEI 202 Query: 208 LDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRIS 267 ++ A +V + + D + +L D + K + ++ + + E +R Sbjct: 203 IEGVATIVGVPNFADYF-PILRPFDPQGVKRRADVFFGKLLAKIEGYLNERL-ESKRANP 260 Query: 268 TEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPN 327 K ++ ++ ++I A + L + +L++ + DT + S+ + + + +P+ Sbjct: 261 NAPKKDDFLEIVVDIIQANEF-KLKTHHFTHLMLDLFVGGSDTNTTSIEWAMSELVMNPD 319 Query: 328 VEEAIIKEIQTVIGE-RDIKIDDIQKLKVMENFIYESMRYQPVVDLV-MRKALEDDVIDG 385 + E+++V G+ + + + KL ++ I E MR P L+ RKA D ++G Sbjct: 320 KMARLKAELKSVAGDEKIVDESAMPKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEVNG 379 Query: 386 YPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNV-----PYRYFQPFGFGPRGCAG 439 Y + KGT I++N + R + P F E F N PFG G R C G Sbjct: 380 YLIPKGTQILINAYAIGRDPSIWTDPETFDPERFLDNKIDFKGQDYELLPFGSGRRVCPG 439 Query: 440 KYIAMVMMKAILVTLLRRFHVKTLQGQC 467 +A ++ TL+ F K Sbjct: 440 MPLATRILHMATATLVHNFDWKLEDDST 467 >3TBG-A nrPDB Length = 479 Score = 277 bits (708), Expect = 9e-75, Method: Composition-based stats. Identities = 88/442 (19%), Positives = 161/442 (36%), Gaps = 36/442 (8%) Query: 73 ACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQC-----IGM 127 + R +G+ + ++ ++++ +++ + + + + G Sbjct: 35 CFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVT--HGEDTADRPPVPITQILGFGP 92 Query: 128 HEKGIIFNNNPELWKTTRPFFMKALSGPGLVR--MVTVCAESLKTHLDRLEEVTN----- 180 +G+ W+ R F + L GL + + E + Sbjct: 93 RSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRP 152 Query: 181 -------ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDI 233 S + LT RR D + FLR+ LD + +K + F + +L + Sbjct: 153 NGLLDKAVSNVIASLTCGRRFEYD--DPRFLRL-LDLAQEGLKEESGF--LREVLNAVPV 207 Query: 234 FFKISWLYKKYEKSVKDLKDAIEVLIAEKRRR---ISTEEKLEECMDFATELILAEKRGD 290 I L K + K ++ L+ E R L E E Sbjct: 208 LLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESS 267 Query: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE-RDIKIDD 349 EN+ + ++ A T S +L + L L+ HP+V+ + +EI VIG+ R ++ D Sbjct: 268 FNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGD 327 Query: 350 IQKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FF 407 + I+E R+ +V L V D + G+ + KGT +I N+ + + E + Sbjct: 328 QAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW 387 Query: 408 PKPNEFTLENFAK----NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTL 463 KP F E+F V F PF G R C G+ +A + + +LL+ F Sbjct: 388 EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVP 447 Query: 464 QGQCVESIQKIHDLSLHPDETK 485 GQ S + + P + Sbjct: 448 TGQPRPSHHGVFAFLVSPSPYE 469 >4H1N-A nrPDB Length = 479 Score = 275 bits (702), Expect = 4e-74, Method: Composition-based stats. Identities = 84/439 (19%), Positives = 165/439 (37%), Gaps = 31/439 (7%) Query: 48 PGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIM 107 PGP +G L+ R G+ + YG+ V++ +++ + ++ + Sbjct: 13 PGPSPLPVLGNLLQMDR---KGLLRSFLRLREKYGDVFTVYLGSRPVVVLCGTDAIREAL 69 Query: 108 K--HNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVR--MVTV 163 +S R G + I G+IF N E W+ R F + + G+ + + Sbjct: 70 VDQAEAFSGR-GKIAVVDPI-FQGYGVIFANG-ERWRALRRFSLATMRDFGMGKRSVEER 126 Query: 164 CAESLKTHLDRLEEVTNESGYVDVL----------TLLRRVMLDTSNTLFLRIPLDESAI 213 E + ++ L + +L +++ D + +FLR+ Sbjct: 127 IQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRLLDLFFQS 186 Query: 214 VVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRI--STEEK 271 I + L +++ ++++++ I + + R + S Sbjct: 187 FSLISSFSSQVFELFSG--FLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPSNPRD 244 Query: 272 LEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEA 331 + E ++ + +N+ +L + A +T S +L + L+ K+P+V E Sbjct: 245 FIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLKYPHVTER 304 Query: 332 IIKEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYPVK 389 + KEI+ VIG R +DD K+ + I+E R ++ V +D GY + Sbjct: 305 VQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRGYVIP 364 Query: 390 KGTNIILNIGRM-HRLEFFPKPNEFTLENFAKN----VPYRYFQPFGFGPRGCAGKYIAM 444 K T + + H +F PN F +F F PF G R C G+ IA Sbjct: 365 KNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRICLGEGIAR 424 Query: 445 VMMKAILVTLLRRFHVKTL 463 + T+L+ F + + Sbjct: 425 TELFLFFTTILQNFSIASP 443 >5E58-A nrPDB Length = 493 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 85/445 (19%), Positives = 163/445 (36%), Gaps = 48/445 (10%) Query: 79 RVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMH--EKGIIFNN 136 YG+ V + +++ + ++ + + F + + I + G+IF+N Sbjct: 60 EKYGDVFTVHLGPRPVVMLYGTEAIREALV--DQAEAFSGRGTIAVIKPVIGDYGMIFSN 117 Query: 137 NPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVML 196 E WK R F + + G+ + ++ DR++E V+ L + L Sbjct: 118 G-ERWKVLRRFSLATMRDFGMGK---------RSVEDRIQE--EAQCLVEELQKSQGAPL 165 Query: 197 DTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIE 256 D + LF I + +V + Y + L D+F++ L + V +L Sbjct: 166 DPT-FLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFSGFM 224 Query: 257 VLIAEKRRRI------------------------STEEKLEECMDFATELILAEKRGDLT 292 R+I S + E + + + Sbjct: 225 KYFPGAHRQITRNLQEILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEKSNQHTEFH 284 Query: 293 RENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-ERDIKIDDIQ 351 +N+ +L + A +T S +L + L+ K+P+V E + KEI VIG R ++D Sbjct: 285 HQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHRLPTLEDRT 344 Query: 352 KLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIGRM-HRLEFFPK 409 K+ + I+E R+ + + K +D + GY + K T + + H ++F + Sbjct: 345 KMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQYFEQ 404 Query: 410 PNEFTLENFAKN----VPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQG 465 P F ++F F PF G R C G+ IA + T+L+ F V + Sbjct: 405 PGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSVSSSVA 464 Query: 466 QCVESIQKIHDLSLHPDETKNMLEM 490 + +T + + Sbjct: 465 PKDIDLSPKESGIGKVPQTYQISFL 489 >5E0E-A nrPDB Length = 463 Score = 269 bits (687), Expect = 2e-72, Method: Composition-based stats. Identities = 80/450 (17%), Positives = 168/450 (37%), Gaps = 51/450 (11%) Query: 58 PLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFG 117 L+ R G ++ YG+ V + +++ + ++ + + F Sbjct: 14 NLLQMDRG---GFLNSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALV--DQAEAFS 68 Query: 118 SKLGLQCIG--MHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRL 175 + + + G++F N E WK R F + + G+ + ++ +R+ Sbjct: 69 GRGTIAVVEPIFRGYGVVFANG-ERWKALRRFSLVTMRDFGMGK---------RSVEERI 118 Query: 176 EEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFF 235 +E V+ + LD + LF I + +V + + L +F+ Sbjct: 119 QE--EARCLVEEFRKSQGAPLDPT-FLFQCITANIICSIVFGERFDYKDHQFLRLLYLFY 175 Query: 236 ----------------------KISWLYKKYEKSVKDLKDAIEVLIAEKRRRIST--EEK 271 +++ ++++++ D I + + R + Sbjct: 176 QSFSLISSFSSQVFELFSGFLKYFPGTHRQISRNLQEILDYIGQSVEKHRATLDPSHPRD 235 Query: 272 LEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEA 331 + E + + + +N+ +L + A +T S +L + L+ K+P+V E Sbjct: 236 FIDTYLLRMEKEKSNQHTEFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEK 295 Query: 332 IIKEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYPVK 389 + KEI VIG R ++D K+ E IYE R+ ++ + V K +D + GY + Sbjct: 296 VQKEIDQVIGSHRLPTLEDRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLP 355 Query: 390 KGTNIILNIGRM-HRLEFFPKPNEFTLENFAKN----VPYRYFQPFGFGPRGCAGKYIAM 444 K T + + H ++F +P+ F ++F F PF G R C G+ IA Sbjct: 356 KNTEVYPILSSALHDPQYFEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIAR 415 Query: 445 VMMKAILVTLLRRFHVKTLQGQCVESIQKI 474 + T+L+ F + + + Sbjct: 416 NELFLFFTTILQNFSLSSPVAPKDIDLSPK 445 >3JUS-A nrPDB Length = 461 Score = 265 bits (677), Expect = 3e-71, Method: Composition-based stats. Identities = 86/461 (18%), Positives = 187/461 (40%), Gaps = 48/461 (10%) Query: 51 GYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIM--K 108 +G I+ G+ + +A YG + G+ + S + + K Sbjct: 18 SPIPFLGHAIAFGKSPIEFLENAY----EKYGPVFSFTMVGKTFTYLLGSDAAALLFNSK 73 Query: 109 HNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESL 168 + ++ + KG+ ++ ++ + L+ + V++ + Sbjct: 74 NEDLNAEDVYSRLTTPV--FGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKET 131 Query: 169 KTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLF----LRIPLDE--SAIVVKIQGYFD 222 K + E ESG +V L +++ T++ +R L+E + + + G F Sbjct: 132 KEYF----ESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFS 187 Query: 223 AWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATEL 282 LL +++ +++ +++KD I ++R+ ++EK+++ + + Sbjct: 188 HAAWLLPGWLPL----PSFRRRDRAHREIKDIFYKAIQKRRQ---SQEKIDDILQTLLDA 240 Query: 283 ILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE 342 + LT + V ++ +L+A T S + +M F +A+ +++ E +TV GE Sbjct: 241 -TYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGE 299 Query: 343 R--DIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGR 400 + D ++ L +++ I E++R +P + ++MR A + GY + G + ++ Sbjct: 300 NLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTV 359 Query: 401 MHRLE-FFPKPNEFTLENFAKNVPYR----YFQPFGFGPRGCAGKYIAMVMMKAILVTLL 455 RL+ + + +F + + ++ P + PFG G C G+ A V +K I T+L Sbjct: 360 NQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTML 419 Query: 456 RRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRN 496 R + + G T N MI TP N Sbjct: 420 RLYEFDLIDGYF---------------PTVNYTTMIHTPEN 445 >4WMZ-A nrPDB Length = 539 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 72/477 (15%), Positives = 177/477 (37%), Gaps = 58/477 (12%) Query: 53 CMGIGPLISHGRFLWMGIGSACNYYNRVY-----GEFMRVWISGEETLIISKSSSMFHIM 107 +G + +G + Y ++ G M V++ + Sbjct: 63 IPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLG----------PKGHEFV 112 Query: 108 KHNHYSSRFGSKL-GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAE 166 + + + KG+I++ + F AL+ V + AE Sbjct: 113 FNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAE 172 Query: 167 SLKTHLDRLEEVT---NESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDA 223 + + + +G +DV+ + + T++ L + Y D Sbjct: 173 EVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLYSDL 232 Query: 224 WQALLIKPDIFFKIS-WLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATEL 282 + +F + Y+K + + K + LI E+R+ +++ + +D + Sbjct: 233 DKGFTPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDR--DLIDSLMKN 290 Query: 283 ILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVI-- 340 + +T + + ++ +L+ T + + ++L +A+ P+V++ + +E V+ Sbjct: 291 STYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLDG 350 Query: 341 GERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDG--YPVKKGTNIILNI 398 G++++ D +Q++ ++ I E++R + + RK ++D + Y + G +++++ Sbjct: 351 GKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSP 410 Query: 399 GRMH-RLEFFPKPNEFTLENFAKNVPYRY--------------------FQPFGFGPRGC 437 G H R E+FP ++F + + + Y + PFG G C Sbjct: 411 GYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRC 470 Query: 438 AGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTP 494 G++ A + ++ +R +G+ V P + +M+ + P Sbjct: 471 IGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVP-----------PPDFTSMVTLPTGP 516 >2PG7-A nrPDB Length = 476 Score = 262 bits (670), Expect = 2e-70, Method: Composition-based stats. Identities = 84/451 (18%), Positives = 177/451 (39%), Gaps = 31/451 (6%) Query: 48 PGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIM 107 PGP IG + + + ++ + YG + + +++ ++ + Sbjct: 13 PGPTPLPFIGN---YLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREAL 69 Query: 108 K--HNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVR--MVTV 163 +S R G + + G++F+N E K R F + L G+ + + Sbjct: 70 VDQAEEFSGR-GEQATFDWV-FKGYGVVFSNG-ERAKQLRRFSIATLRDFGVGKRGIEER 126 Query: 164 CAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNT-----LFLRIPLDESAIVVKIQ 218 E +D L + +D L R + + ++ F + +++ + Sbjct: 127 IQEEAGFLIDALRGTGGAN--IDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMML 184 Query: 219 GYF-----DAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRI--STEEK 271 G F Q + + + ++ + ++ L+D I + +R + ++ Sbjct: 185 GIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRD 244 Query: 272 LEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEA 331 + + + +N+ L++ + +T+S +L + L+ KHP VE Sbjct: 245 FIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMKHPEVEAK 304 Query: 332 IIKEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYPVK 389 + +EI VIG R K +D K+ ME I+E R+ V+ + + R+ +D + + Sbjct: 305 VHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLP 364 Query: 390 KGTNIILNIGRMHR-LEFFPKPNEFTLENF----AKNVPYRYFQPFGFGPRGCAGKYIAM 444 KGT + +G + R FF P +F ++F + F PF G R C G+ +A Sbjct: 365 KGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLAR 424 Query: 445 VMMKAILVTLLRRFHVKTLQGQCVESIQKIH 475 + + T+++ F +K+ Q + H Sbjct: 425 MELFLFFTTVMQNFRLKSSQSPKDIDVSPKH 455 >3K9V-A nrPDB Length = 482 Score = 262 bits (668), Expect = 4e-70, Method: Composition-based stats. Identities = 92/476 (19%), Positives = 209/476 (43%), Gaps = 42/476 (8%) Query: 45 SSIPGPGYCMGIGPLISHGRFLWMGIGSACN----YYNRVYGEFMRVWISGEETLIISKS 100 + +PGP +G L+ W G + Y++ YG+ R+ + +++ + Sbjct: 24 TDLPGPTNWPLLGSLL---EIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSP 80 Query: 101 SSMFHIMKHNHYSSRFGSKLGLQCIGMHEK---GIIFNNNPELWKTTRPFFMKALSGP-G 156 S + + + + + H G++ E W+ R F K L P Sbjct: 81 SLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQE-WQRVRSAFQKKLMKPVE 139 Query: 157 LVRMVTVCAESLKTHLDRLEEVTNESGYV-DVLTLLRR-------VMLDTSNTLFLRIPL 208 ++++ E L L+R++E+ +E G + D+ + L + ++L L+ Sbjct: 140 IMKLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKET 199 Query: 209 DESAI--VVKIQGYFDAWQALLIKPDIFFKI--SWLYKKYEKSVKDLKDAIEVLIAEKRR 264 +E A+ + I+ + +++ P K + +++ + + + +++ I + + Sbjct: 200 EEEALTFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQ 259 Query: 265 RISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAK 324 R S + DF ++ ++ L+++ + + E+ +AA +T + SL ++L+ +++ Sbjct: 260 RYSQQ----PGADFLCDIY---QQDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSR 312 Query: 325 HPNVEEAIIKEIQTVIGERD-IKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI 383 +P + +++E+Q+V+ + + +D++ + ++ + ESMR P V R + V+ Sbjct: 313 NPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVL 372 Query: 384 DGYPVKKGTNIILNIGRMHRLEF-FPKPNEFTLENF---AKNVPYRYFQPFGFGPRGCAG 439 Y + KGT + LN + E F ++F E + K + PFG G R C G Sbjct: 373 GEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEKKINPFAHLPFGIGKRMCIG 432 Query: 440 KYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPR 495 + +A + + L +++++ + + VE +H L P L + F PR Sbjct: 433 RRLAELQLHLALCWIIQKYDIVATDNEPVE---MLHLGILVPSR---ELPIAFRPR 482 >6C94-A nrPDB Length = 497 Score = 260 bits (665), Expect = 8e-70, Method: Composition-based stats. Identities = 89/476 (18%), Positives = 182/476 (38%), Gaps = 43/476 (9%) Query: 46 SIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFH 105 S PGP G + + G + + + +W+ + Sbjct: 23 SFPGPPTHWLFGHALEIQK---TGSLDKVVTWTQQFPYAHPLWVGQFIGFLNIYEPDYAK 79 Query: 106 IMKHN-HYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVC 164 + + LQ IG KG++ + P+ W R L V + Sbjct: 80 AVYSRGDPKAPDVYDFFLQWIG---KGLLVLDGPK-WFQHRKLLTPGFHYDVLKPYVAIF 135 Query: 165 AESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRI------------PLDESA 212 A+S + L++ E+ E D+ + + + LDT + S Sbjct: 136 ADSTRIMLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGKGDSGLNHRDSSYYVAVSE 195 Query: 213 IVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKL 272 + + +Q D++Q D + ++ +++ ++ + D + +I +++ + E++ Sbjct: 196 LTLLMQQRIDSFQ---YHNDFIYWLTPHGRRFLRACRAAHDHTDRVIRQRKAALQDEKER 252 Query: 273 EEC-----MDFATELILAEKRG--DLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKH 325 E+ +DF L+ L+ ++ + + DT + + + L+ +A + Sbjct: 253 EKIQNRRHLDFLDILLDVRGESGVQLSDTDLRAEVDTFMFEGHDTTTSGISWFLYCMALY 312 Query: 326 PNVEEAIIKEIQTVIGERD-IKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDV-I 383 P ++ +E++ ++G++D + +D+ K+ + + E R P V V R+ + + Sbjct: 313 PEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQVYRQLSKPVSFV 372 Query: 384 DGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENFAKN----VPYRYFQPFGFGPRGCA 438 DG + G+ I L+I +HR + +P P F F+ F PF GPR C Sbjct: 373 DGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRHPYAFIPFSAGPRNCI 432 Query: 439 GKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTP 494 G+ AM MK + L RF + K+ L L +KN + + P Sbjct: 433 GQQFAMNEMKVVTALCLLRFEFSV---DPLRLPIKLPQLVLR---SKNGIHLYLKP 482 >3DL9-A nrPDB Length = 479 Score = 260 bits (664), Expect = 1e-69, Method: Composition-based stats. Identities = 85/432 (19%), Positives = 168/432 (38%), Gaps = 28/432 (6%) Query: 75 NYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEK--GI 132 ++VYGE + + G T++++ + + H S F + L K G+ Sbjct: 41 RKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQ--SEIFADRPCLPLFMKMTKMGGL 98 Query: 133 IFNNNPELWKTTRPFFMKALS--GPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 190 + + W R + + G G + E K D +E D L Sbjct: 99 LNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGR--PFDFKQL 156 Query: 191 LRRVMLDTSNTLFLRIPLD-ESAIVVKIQGYFDAWQALLIKPDIFFK--ISWL------- 240 + + + +N + E + F L +F W+ Sbjct: 157 ITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGK 216 Query: 241 YKKYEKSVKDLKDAIEVLIAEK--RRRISTEEKLEECMDFATELILAEKRGDLTRENVNQ 298 +++ ++ + D + LI + R+ + + + + ++EN+ Sbjct: 217 HQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIF 276 Query: 299 CILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGER-DIKIDDIQKLKVME 357 + E++IA +T + L + + +A +PN++ + KEI ++G DD K+ E Sbjct: 277 SVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTE 336 Query: 358 NFIYESMRYQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIGRMH-RLEFFPKPNEFTL 415 ++E +R+ +V L + ED V+ GY + KGT +I N+ +H +++ P F Sbjct: 337 AVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHP 396 Query: 416 ENFAKN----VPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESI 471 E F + PF G R C G+++A + M LL+RFH+ + V + Sbjct: 397 ERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPH-ELVPDL 455 Query: 472 QKIHDLSLHPDE 483 + ++L P Sbjct: 456 KPRLGMTLQPQP 467 >3IBD-A nrPDB Length = 476 Score = 258 bits (660), Expect = 3e-69, Method: Composition-based stats. Identities = 75/410 (18%), Positives = 160/410 (39%), Gaps = 28/410 (6%) Query: 77 YNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKG--IIF 134 + YG+ V + +++ ++ + + F + + + +G +IF Sbjct: 39 FREKYGDVFTVHLGPRPVVMLCGVEAIREALVDK--AEAFSGRGKIAMVDPFFRGYGVIF 96 Query: 135 NNNPELWKTTRPFFMKALSGPGLVR--MVTVCAESLKTHLDRLEEVTNESGYVDVLTLLR 192 N WK R F + + G+ + + E + ++ L + +D L + Sbjct: 97 ANGN-RWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKG--ALMDPTFLFQ 153 Query: 193 RVMLDT-SNTLFLRIPLDESAIVVKIQGYFDAWQALLIKP---------DIFFKISWLYK 242 + + + +F + + +K+ F +L+ ++ Sbjct: 154 SITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKHFPGAHR 213 Query: 243 KYEKSVKDLKDAIEVLIAEKRRRIST--EEKLEECMDFATELILAEKRGDLTRENVNQCI 300 + K+++++ I + + R + L + E + + + +N+N Sbjct: 214 QVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSNAHSEFSHQNLNLNT 273 Query: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-ERDIKIDDIQKLKVMENF 359 L + A +T S +L + L+ K+P+V E + +EI+ VIG R ++ D K+ E Sbjct: 274 LSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAV 333 Query: 360 IYESMRYQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIG-RMHRLEFFPKPNEFTLEN 417 IYE R+ ++ + V + GY + K T + L + +H +F KP+ F ++ Sbjct: 334 IYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDH 393 Query: 418 FAKN----VPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTL 463 F F PF G R C G+ IA + T+L+ F + + Sbjct: 394 FLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP 443 >5JLC-A nrPDB Length = 515 Score = 257 bits (656), Expect = 8e-69, Method: Composition-based stats. Identities = 87/491 (17%), Positives = 180/491 (36%), Gaps = 84/491 (17%) Query: 53 CMGIGPLISHGRFLWMGIGSACNYYNRVY-----GEFMRVWISGEETLIISKSSSMFHIM 107 +G I +G + Y ++ G M V++ + Sbjct: 45 IPWVGSAIPYGTKPYEFFEDCQKKYGDIFSFMLLGRIMTVYLG----------PKGHEFI 94 Query: 108 KHNHYSSRFGSKL-GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAE 166 + + + KG+I++ + F AL+ VR V + AE Sbjct: 95 FNAKLADVSAEAAYSHLTTPVFGKGVIYDCPNHRLMEQKKFVKGALTKEAFVRYVPLIAE 154 Query: 167 SLKTHLDRLEEVT---NESGYVDVL-------------TLLRRVMLDTSNTLFLRIPLDE 210 + + + N SG VDV+ +LL + M D +T F + D Sbjct: 155 EIYKYFRNSKNFKINENNSGIVDVMVSQPEMTIFTASRSLLGKEMRDKLDTDFAYLYSDL 214 Query: 211 SAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEE 270 I F P++ + Y+K + + + + LI E+R + + Sbjct: 215 DKGFTPINFVF---------PNLPLE---HYRKRDHAQQAISGTYMSLIKERREKNDIQN 262 Query: 271 KLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEE 330 + + +D + + +T + + ++ +L+ T + + + L +A+ P+V+E Sbjct: 263 R--DLIDELMKNSTYKDGTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPDVQE 320 Query: 331 AIIKEIQTVIGE--RDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDG--Y 386 + +E V+ +++ DD+Q + ++ I E++R + + RK + D I Y Sbjct: 321 ELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPLHSLFRKVMRDVAIPNTSY 380 Query: 387 PVKKGTNIILNIGRMH-RLEFFPKPNEFTLENFAKNVPYRY------------------- 426 V + +++++ G H + EFFPKPNEF + + + Sbjct: 381 VVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDYGFGAISKGVS 440 Query: 427 --FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTL-QGQCVESIQKIHDLSLHPDE 483 + PFG G C G+ A + ++ +R + +G+ V P + Sbjct: 441 SPYLPFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRYPTEGETVP-----------PSD 489 Query: 484 TKNMLEMIFTP 494 +M+ + P Sbjct: 490 FTSMVTLPTAP 500 >5VBU-A nrPDB Length = 476 Score = 254 bits (648), Expect = 7e-68, Method: Composition-based stats. Identities = 83/422 (19%), Positives = 166/422 (39%), Gaps = 24/422 (5%) Query: 78 NRVYGEFMRVWISGEETLIISKSSSMFHIMKHN--HYSSRFGSKLGLQCIGMHEKGIIFN 135 + +G R+ + ++ ++++ ++ M ++ R L + + + + Sbjct: 34 TQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGR-PEPLTYKLVSRNYPDLSLG 92 Query: 136 NNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN-ESGYVDVLTLLRRV 194 + LWK + AL M V + + +R+ + +LL Sbjct: 93 DYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCS 152 Query: 195 MLDTSNTLFLRIPLDESAIVVK-IQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKD 253 ++ + K IQ W I I +L ++ LK Sbjct: 153 IICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHW--SIQIVDVIPFLRFFPNPGLRRLKQ 210 Query: 254 AIEVL--IAEKRRRISTE----EKLEECMDFATELILA----EKRGDLTRENVNQCILEM 303 AIE I E + R E + + MD+ + + E G L +V+ +++ Sbjct: 211 AIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDL 270 Query: 304 LIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG----ERDIKIDDIQKLKVMENF 359 LI +T + +L + + + HP +++ + +E+ +G + D +L ++ Sbjct: 271 LIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNAT 330 Query: 360 IYESMRYQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLEN 417 I E +R +PVV L + + I GY + +GT II N+ H E + +P+EF + Sbjct: 331 IAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDR 390 Query: 418 FAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDL 477 F + FG G R C G+ +A + + +L LL+ F + G + S+Q + Sbjct: 391 FLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTL-LPSGDALPSLQPLPHC 449 Query: 478 SL 479 S+ Sbjct: 450 SV 451 >3QZ1-A nrPDB Length = 496 Score = 243 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 69/426 (16%), Positives = 150/426 (35%), Gaps = 25/426 (5%) Query: 78 NRVYGEFMRVWISGEETLIISKSSSMFHIMKHN--HYSSRFGSKLGLQCIGMHEKGIIFN 135 + G R+ + +E ++++ ++ M ++ R + + + I Sbjct: 53 TQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAGR-PQIPSYKLVSQRCQDISLG 111 Query: 136 NNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVM 195 + LWK + AL M + + +R+ V + + Sbjct: 112 DYSLLWKAHKKLTRSALLLGTRSSMEPWVDQLTQEFCERMRVQAG--APVTIQKEFSLLT 169 Query: 196 LDTSNTLFLRIPLDESAIVVKI--QGYFDAW----QALLIKPDIFFKISWLYKKYEKSVK 249 L D Q W +L K Sbjct: 170 CSIICYLTFGNKEDTLVHAFHDCVQDLMKTWDHWSIQILDMVPFLRFFPNPGLWRLKQAI 229 Query: 250 DLKDAIEVLIAEKRRRISTEEKLEECMDFATELI----LAEKRGDLTRENVNQCILEMLI 305 + +D + + + + + D+ + + + E G L +V+ ++++ I Sbjct: 230 ENRDHMVEKQLRRHKESMVAGQWRDMTDYMLQGVGRQRVEEGPGQLLEGHVHMSVVDLFI 289 Query: 306 AAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE----RDIKIDDIQKLKVMENFIY 361 +T + +L + + + HP ++ + +E+ +G + D +L ++ I Sbjct: 290 GGTETTASTLSWAVAFLLHHPEIQRRLQEELDRELGPGASCSRVTYKDRARLPLLNATIA 349 Query: 362 ESMRYQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFA 419 E +R +PVV L + + I GY + +G +I N+ H E + +P+EF + F Sbjct: 350 EVLRLRPVVPLALPHRTTRPSSIFGYDIPEGMVVIPNLQGAHLDETVWEQPHEFRPDRFL 409 Query: 420 KNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIH---- 475 + FG G R C G+ +A + + +L LL+ F + + S+Q Sbjct: 410 EPGANPSALAFGCGARVCLGESLARLELFVVLARLLQAFTLLPPPVGALPSLQPDPYCGV 469 Query: 476 DLSLHP 481 +L + P Sbjct: 470 NLKVQP 475 >6AYB-A nrPDB Length = 466 Score = 243 bits (619), Expect = 2e-64, Method: Composition-based stats. Identities = 87/451 (19%), Positives = 179/451 (39%), Gaps = 27/451 (5%) Query: 50 PGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKH 109 P +G +S + I ++ YG+ I G+E ++ + K Sbjct: 16 PNLIPYVGSFVSFAKNPVQFIIDN----SKKYGDVFTATILGKEMTFLNHPKILDTFFKA 71 Query: 110 NHYSSRFGSKLGLQCIGM-HEKGIIF-NNNPELWKTTRPFFMKALSGPGLVRMVTVCAES 167 + + + + G+++ ++ E F L+ V + + Sbjct: 72 TD--NELSLRDVYRFMRPVFGTGVVYDADSTERMMEQVKFVSSGLTTARFRVFVDIFEDE 129 Query: 168 LKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQAL 227 + + L G VDV L+ +++ T++ L + + + K G Sbjct: 130 IAHKVKEL----GPEGTVDVAELMADLIIFTASRCLLGDEVRQY-LSEKNLGKLYHDIDD 184 Query: 228 LIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRR--RISTEEKLEECMDFATELILA 285 I P FF S K +K+ K + + + L+ ++R + E L+E + +L Sbjct: 185 GISPLSFFYPSLPAPKRDKARKAVGEIFQELLDKRREEHKKHPERLLDESKMDVVDHLLT 244 Query: 286 EKRGD---LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG- 341 +K D LT + ++ L A T S++ + L + + V E + KE + ++G Sbjct: 245 QKYKDGQELTDVHRIGILIAGLFAGQHTSSITSSWTLMNVISNKKVLEKVRKEQEEIMGS 304 Query: 342 ERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRM 401 ++ + D + K+ +E + E++R P + ++MR A + + Y + KG ++++ Sbjct: 305 DKVLDYDKVMKMDYLEACMKEALRMYPPLIMIMRMARKPRECEQYIIPKGNILVVSPSVA 364 Query: 402 HR-LEFFPKPNEFTLENFAKNVPYRYF----QPFGFGPRGCAGKYIAMVMMKAILVTLLR 456 R + + P+ F E + + F PFG G C G+ A++ +K+I+ LLR Sbjct: 365 GRCTDTYTNPDVFDPERLTERKEHEKFKYGAVPFGAGRHKCIGENFALLQVKSIISILLR 424 Query: 457 RFHVKTLQGQCVESIQKIHDLSLHPDETKNM 487 F ++ + S L + P M Sbjct: 425 YFDMEYIGKIPDPSYT---SLVVGPSPPTRM 452 >6CR2-A nrPDB Length = 477 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 71/440 (16%), Positives = 159/440 (36%), Gaps = 36/440 (8%) Query: 54 MGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISK--SSSMFHIMKHNH 111 IG IS+G + Y + F + + + T+ + + + + + Sbjct: 14 PFIGSTISYGIDPYKFFFDCRAKYGDI---FTFILLGKKTTVYLGTKGNDFILNGKLRDV 70 Query: 112 YSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTH 171 + S L G H ++++ + F L+ L V + + +++ Sbjct: 71 CAEEVYSPLTTPVFGRH---VVYDCPNAKLMEQKKFVKYGLTSDALRSYVPLITDEVESF 127 Query: 172 LDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKP 231 + G DV + + + T++ + + Y + Sbjct: 128 VKNSPAFQGHKGVFDVCKTIAEITIYTASRSLQGKEVRSKFDSTFAELYHNLDMGFAPIN 187 Query: 232 DIFFKIS-WLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD 290 + +K + + + L + +I +R+ + +K E M + + + Sbjct: 188 FMLPWAPLPHNRKRDAAQRKLTETYMEIIKARRQ--AGSKKDSEDMVWNLMSCVYKNGTP 245 Query: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE--RDIKID 348 + E + ++ +L+A + S + +++ +A P++ E + +E V+G + D Sbjct: 246 VPDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVLGSDLPPLTYD 305 Query: 349 DIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDG--YPVKKGTNIILNIGRMHR-LE 405 ++QKL + I E++R + ++R +DG Y + N++ + G R E Sbjct: 306 NLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSHNVLSSPGVTARSEE 365 Query: 406 FFPKPNEFTLENFAKNVPYRY--------------------FQPFGFGPRGCAGKYIAMV 445 FP P E+ + +N+ + PFG G C G+ A + Sbjct: 366 HFPNPLEWNPHRWDENIAASAEDDEKVDYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYL 425 Query: 446 MMKAILVTLLRRFHVKTLQG 465 + I L+R F + L G Sbjct: 426 QLGTITAVLVRLFRFRNLPG 445 >6DWN-A nrPDB Length = 491 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 85/473 (17%), Positives = 181/473 (38%), Gaps = 42/473 (8%) Query: 42 EGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSS 101 +G + PGP IG +++ G+ A + ++ YG+ +++ I +++S Sbjct: 8 KGLKNPPGPWGWPLIGHMLTLGK----NPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLD 63 Query: 102 SMFHIMKHNHYSSRFGSKLGLQCIGM--HEKGIIFN-NNPELWKTTRPFFMKALSGPGLV 158 ++ + F + L + + + + F+ ++ +W R L + Sbjct: 64 TIRQALVRQ--GDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIA 121 Query: 159 R---------MVTVCAESLKTHLDRLEEVTNESGYVDVLT-LLRRVMLDTSNTLFLRIPL 208 + ++ + + L+E+ G+ + ++ V F R Sbjct: 122 SDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYD 181 Query: 209 DESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDA-------IEVLIAE 261 ++ + + + ++ + I L S+ KD ++ ++ E Sbjct: 182 HNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKE 241 Query: 262 KRRRISTEEKLEECMDFATELILAEKRGD-----LTRENVNQCILEMLIAAPDTMSVSLF 316 + + + + D E ++ + L+ E + +L++ A DT++ ++ Sbjct: 242 HY-KTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAIS 300 Query: 317 FMLFLIAKHPNVEEAIIKEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDL-VM 374 + L + +P V+ I +E+ TVIG R ++ D L ME FI E+ R+ V + Sbjct: 301 WSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIP 360 Query: 375 RKALEDDVIDGYPVKKGTNIILNIGR-MHRLEFFPKPNEFTLENFA------KNVPYRYF 427 D + G+ + KG + +N + H + + P+EF E F V Sbjct: 361 HSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKV 420 Query: 428 QPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480 FG G R C G+ IA + L LL+R G V + I+ L++ Sbjct: 421 IIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKV-DMTPIYGLTMK 472 >3EL3-A nrPDB Length = 467 Score = 239 bits (609), Expect = 3e-63, Method: Composition-based stats. Identities = 81/442 (18%), Positives = 177/442 (40%), Gaps = 33/442 (7%) Query: 58 PLISHGRFLWMGIGSACNYYN--RVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSR 115 PL+ HG W + + R +G+ +R+ + + ++ + + Y Sbjct: 32 PLLGHG---WRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIA 88 Query: 116 FGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRL 175 L+ + + ++G+ N P + R A + + E +R Sbjct: 89 GPLWESLEGL-LGKEGVATANGPLH-RRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERW 146 Query: 176 EEVTNESGYVDVLTLLRRVMLDTSNTLFLRIP-----LDESAIVVKIQGYFDAWQALLIK 230 + VD + RV + + LR + + + + ++ Sbjct: 147 Q----PGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPL 202 Query: 231 PDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILA--EKR 288 ++ +++ ++ DL ++ +IAE+R + D T L+ A + Sbjct: 203 GPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPD------DLLTALLEAKDDNG 256 Query: 289 GDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKID 348 + + ++ ++ +L +T++ ++ ++L +A HP + I E++ V G R + + Sbjct: 257 DPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFE 316 Query: 349 DIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFF 407 D++KL+ N I E+MR +P V ++ R+A+ + + GY + G +II + + R + + Sbjct: 317 DVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSY 376 Query: 408 PKPNEFTLENFAK----NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTL 463 EF + + NVP +PF G R C + +M + I L ++ + + Sbjct: 377 DDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQV 436 Query: 464 QGQC----VESIQKIHDLSLHP 481 G V + HDL + P Sbjct: 437 AGSNDAVRVGITLRPHDLLVRP 458 >2W0A-A nrPDB Length = 455 Score = 237 bits (604), Expect = 9e-63, Method: Composition-based stats. Identities = 72/397 (18%), Positives = 162/397 (40%), Gaps = 27/397 (6%) Query: 82 GEFMRVWISGEETLIIS-KSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPEL 140 G+ ++G++ +++S ++ F + + + + I + ++F+ +PE Sbjct: 38 GDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMTPI--FGEAVVFDASPER 95 Query: 141 WKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSN 200 K AL G + A +++ + R+ E+G +D+L + + TS+ Sbjct: 96 RKEM--LHNAALRG----EQMKGHAATIEDQVRRMIADWGEAGEIDLLDFFAELTIYTSS 149 Query: 201 TLFLRIPL--DESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVL 258 + K+ + L D + I ++ + ++ + L Sbjct: 150 ACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYLPIESFRRR-----DEARNGLVAL 204 Query: 259 IAE-KRRRISTEEKLEECMDFATELILAEKRGD---LTRENVNQCILEMLIAAPDTMSVS 314 +A+ RI+ + D LI + + + + + M+ A T S + Sbjct: 205 VADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGT 264 Query: 315 LFFMLFLIAKHPNVEEAIIKEIQTVIGE-RDIKIDDIQKLKVMENFIYESMRYQPVVDLV 373 + L + +H + A+I E+ + G+ R + ++++ +EN + E++R P + ++ Sbjct: 265 ASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQLENVLKETLRLHPPLIIL 324 Query: 374 MRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPY-----RYF 427 MR A + + G+ + +G + + +R E FP P++F + + + Sbjct: 325 MRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTW 384 Query: 428 QPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQ 464 PFG G C G A++ +KAI LLR + + Q Sbjct: 385 IPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQ 421 >3MZS-A nrPDB Length = 486 Score = 236 bits (603), Expect = 1e-62, Method: Composition-based stats. Identities = 97/488 (19%), Positives = 190/488 (38%), Gaps = 44/488 (9%) Query: 45 SSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYN-----RVYGEFMRVWISGEETLIISK 99 S IP PG G L + W GS ++ + YG R + E++ I Sbjct: 11 SEIPSPGDN---GWLNLYH--FWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIH 65 Query: 100 SSSMFHIMKHNHYSSRFGSKLGLQCIGMHEK------GIIFNNNPELWKTTRPFFMK-AL 152 + H+ K + + + + + + G++F + WK R + Sbjct: 66 PEDVAHLFK---FEGSYPERYDIPPWLAYHRYYQKPIGVLFKKSG-TWKKDRVVLNTEVM 121 Query: 153 SGPGLVRMVTVCAESLKTHLDRLEEVTNESG----YVDVLTLLRRVMLDTSNTLFLRIPL 208 + + + + + + L + + G D+ L ++ + L Sbjct: 122 APEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERL 181 Query: 209 DESAIVV--KIQGYFDAWQALL-IKPDIFFKISWLYK-KYEKSVKDLKDAIEVLIAEKRR 264 V + Q + DA + + LY+ K+ +D A + + + + Sbjct: 182 GMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEK 241 Query: 265 RI----STEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLF 320 + E ++ L K + E+V I EML +T S++L + L+ Sbjct: 242 YTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANITEMLAGGVNTTSMTLQWHLY 301 Query: 321 LIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKL-KVMENFIYESMRYQPVVDLVMRKALE 379 +A+ NV+E + +E+ + + I + ++ +++ I E++R P+ + R Sbjct: 302 EMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYPES 361 Query: 380 DDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENF-AKNVPYRYF--QPFGFGPR 435 D V+ Y + T + + I M R FF P++F + +K+ +F FG+G R Sbjct: 362 DLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIHFRNLGFGWGVR 421 Query: 436 GCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPR 495 C G+ IA + M L+ +L F V+ Q + + I +L L PD+ + ++F P Sbjct: 422 QCVGRRIAELEMTLFLIHILENFKVEM---QHIGDVDTIFNLILTPDKP---IFLVFRPF 475 Query: 496 NSDRCLEH 503 N D H Sbjct: 476 NQDPPQAH 483 >2HI4-A nrPDB Length = 495 Score = 235 bits (599), Expect = 4e-62, Method: Composition-based stats. Identities = 84/471 (17%), Positives = 178/471 (37%), Gaps = 39/471 (8%) Query: 42 EGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSS 101 +G S P P +G +++ G+ A + ++ YG+ +++ I L++S+ Sbjct: 13 KGLKSPPEPWGWPLLGHVLTLGK----NPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLD 68 Query: 102 SMFHIMKHNHYSSRFGSKLGL--QCIGMHEKGIIFN-NNPELWKTTRPFFMKALSGPGLV 158 ++ + F + L + + + F+ ++ +W R AL+ + Sbjct: 69 TIRQALVRQ--GDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIA 126 Query: 159 R---------MVTVCAESLKTHLDRLEEVTNESGYVDVLT-LLRRVMLDTSNTLFLRIPL 208 + ++ K + RL+E+ G+ D ++ V F + Sbjct: 127 SDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFP 186 Query: 209 DESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLI---AEKRRR 265 + S ++ + + + L +++ K + + + + Sbjct: 187 ESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQE 246 Query: 266 ISTEEKLEECMDFATELILAEKRGD------LTRENVNQCILEMLIAAPDTMSVSLFFML 319 + D L K+G + +E + + ++ A DT++ ++ + L Sbjct: 247 HYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSL 306 Query: 320 FLIAKHPNVEEAIIKEIQTVIG-ERDIKIDDIQKLKVMENFIYESMRYQPVVDL-VMRKA 377 + P ++ I KE+ TVIG ER ++ D +L +E FI E+ R+ + + Sbjct: 307 MYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHST 366 Query: 378 LEDDVIDGYPVKKGTNIILNIG-RMHRLEFFPKPNEFTLENF------AKNVP-YRYFQP 429 D ++G+ + K + +N H E + P+EF E F A N P Sbjct: 367 TRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMML 426 Query: 430 FGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480 FG G R C G+ +A + L LL++ G V + I+ L++ Sbjct: 427 FGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKV-DLTPIYGLTMK 476 >2VE3-A nrPDB Length = 444 Score = 233 bits (595), Expect = 1e-61, Method: Composition-based stats. Identities = 77/433 (17%), Positives = 161/433 (37%), Gaps = 25/433 (5%) Query: 48 PGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIM 107 PG +G ++ + G + +G + + G+ + IS ++ + Sbjct: 15 PGDFGLPWLGETLNF-----LNDGDFGKKRQQQFGPIFKTRLFGKNVIFISG--ALANRF 67 Query: 108 KHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAES 167 F + L + + E+ ++ R +A L + Sbjct: 68 LFTKEQETFQATWPLSTRILLGPNALATQMGEIHRSRRKILYQAFLPRTLDSYLPKMDGI 127 Query: 168 LKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQAL 227 ++ +L++ ++ V LRR+ D + TLF+ + ++ + W Sbjct: 128 VQGYLEQW----GKANEVIWYPQLRRMTFDVAATLFMGEKVSQNPQLFP-------WFET 176 Query: 228 LIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEK 287 I+ I + KS + + L + R E+ + + Sbjct: 177 YIQGLFSLPIPLPNTLFGKSQRARALLLAELEKIIKARQQQPPSEEDALGILLAA-RDDN 235 Query: 288 RGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKI 347 L+ + IL +L A +T++ +L L+ +H ++ E + +E + +++ Sbjct: 236 NQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQEQNKLQLSQELTA 295 Query: 348 DDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMH-RLEF 406 + ++K+ ++ + E +R P V R+ ++D G+ KG + I + H + Sbjct: 296 ETLKKMPYLDQVLQEVLRLIPPVGGGFRELIQDCQFQGFHFPKGWLVSYQISQTHADPDL 355 Query: 407 FPKPNEFTLENFAKNV-----PYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461 +P P +F E F + P PFG G R C GK A + MK L+++F Sbjct: 356 YPDPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECLGKEFARLEMKLFATRLIQQFDWT 415 Query: 462 TLQGQCVESIQKI 474 L GQ +E + Sbjct: 416 LLPGQNLELVVTP 428 >5FSA-A nrPDB Length = 490 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 83/496 (16%), Positives = 171/496 (34%), Gaps = 66/496 (13%) Query: 53 CMGIGPLISHGRFLWMGIGSACNYYNRVY-----GEFMRVWISGEETLIISKSSSMFHIM 107 G S+G+ + S Y V+ G+ M V++ + Sbjct: 13 IPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLG----------PKGHEFV 62 Query: 108 KHNHYSSRFGSKL-GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAE 166 + S + + G+I++ + F AL+ R V E Sbjct: 63 FNAKLSDVSAEEAYKHLTTPVFGTGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIRE 122 Query: 167 SLKTHL---DRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDA 223 + + + + G +V+ + + T++ + Q Y D Sbjct: 123 EILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDL 182 Query: 224 WQALLIKPDIFFKIS-WLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATEL 282 + +F + Y + + + K + I +R R ++ D L Sbjct: 183 DKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKLRRER----GDIDPNRDLIDSL 238 Query: 283 ILAEKRGD---LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTV 339 ++ D +T + + ++ +L+ T + + + L + + P++++ I +E+ + Sbjct: 239 LIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVEL 298 Query: 340 IGER-----DIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGT 392 + E+ D+ +D+QKL + N I E++R + + RK I Y V KG Sbjct: 299 LKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGH 358 Query: 393 NIILNIGRMHRLE-FFPKPNEFTLENF--------------AKNVPYRY----------F 427 ++++ G H E +F P +F + + V Y + + Sbjct: 359 YVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPY 418 Query: 428 QPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNM 487 PFG G C G+ A V + IL T + T+ G V + + P E + Sbjct: 419 LPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRW-TIDGYKVPD-PDYSSMVVLPTEPAEI 476 Query: 488 LEMIFTPRNSDRCLEH 503 + + C+ H Sbjct: 477 IW-----EKRETCMFH 487 >3N9Z-A nrPDB Length = 487 Score = 223 bits (569), Expect = 1e-58, Method: Composition-based stats. Identities = 80/447 (17%), Positives = 170/447 (38%), Gaps = 31/447 (6%) Query: 79 RVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHE---KGI-IF 134 + YG R + E++ + + + K + L + H+ + I + Sbjct: 43 QKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPE--RFLIPPWVAYHQYYQRPIGVL 100 Query: 135 NNNPELWKTTR-PFFMKALSGPGLVRMVTVCAESLKTHL----DRLEEVTNESGYVDVLT 189 WK R + ++ + + + + R+++ + + D+ Sbjct: 101 LKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISD 160 Query: 190 LLRRVMLDTSNTLFLRIPLDESAIVV--KIQGYFDAWQALL-IKPDIFFKISWLYK-KYE 245 L R ++ + VV + Q + DA + + L++ Sbjct: 161 DLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRT 220 Query: 246 KSVKDLKDAIEVLIAEKRRRIST-----EEKLEECMDFATELILAEKRGDLTRENVNQCI 300 K+ KD A +V+ ++ +K D+ L ++ E++ + Sbjct: 221 KTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANV 280 Query: 301 LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKL-KVMENF 359 EML DT S++L + L+ +A++ V++ + E+ + + + +L +++ Sbjct: 281 TEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKAS 340 Query: 360 IYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENF 418 I E++R P+ + R + D V+ Y + T + + I + R FF P F + Sbjct: 341 IKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRW 400 Query: 419 ---AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIH 475 KN+ Y FG+G R C G+ IA + M L+ +L F V+ Q + + Sbjct: 401 LSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEI---QHLSDVGTTF 457 Query: 476 DLSLHPDETKNMLEMIFTPRNSDRCLE 502 +L L P++ + F P N + + Sbjct: 458 NLILMPEKP---ISFTFWPFNQEATQQ 481 >4KPA-A nrPDB Length = 494 Score = 220 bits (561), Expect = 9e-58, Method: Composition-based stats. Identities = 81/419 (19%), Positives = 165/419 (39%), Gaps = 25/419 (5%) Query: 82 GEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPEL- 140 GE + G T +S + + + L+ + +F + Sbjct: 61 GEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQ--ALKFVRDFAGDGLFTSWTHEK 118 Query: 141 -WKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTS 199 WK + + S + + + + + E + N +++V + R+ LDT Sbjct: 119 NWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERL-NADEHIEVPEDMTRLTLDTI 177 Query: 200 NTLFLRIPLDESAIVVKIQGYFDAWQAL--------LIKPDIFFKISWLYKKYEKSVKDL 251 + +AL PD +++++ +K + Sbjct: 178 GLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDEN-KRQFQEDIKVM 236 Query: 252 KDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTM 311 D ++ +IA+++ ++ E+ ++ + E L EN+ I+ LIA +T Sbjct: 237 NDLVDKIIADRK---ASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETT 293 Query: 312 SVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVD 371 S L F L+ + K+P+V + +E V+ + +++LK + + E++R P Sbjct: 294 SGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAP 353 Query: 372 LVMRKALEDDVIDG-YPVKKGTNIILNIGRMHRLE--FFPKPNEFTLENFAKN--VPYRY 426 A ED V+ G YP++KG +++ I ++HR + + EF E F +P Sbjct: 354 AFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHA 413 Query: 427 FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETK 485 F+PFG G R C G+ A+ +L +L+ F + ++ + L+L P+ Sbjct: 414 FKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKET---LTLKPEGFV 469 >6IQ5-A nrPDB Length = 463 Score = 218 bits (554), Expect = 6e-57, Method: Composition-based stats. Identities = 72/449 (16%), Positives = 157/449 (34%), Gaps = 40/449 (8%) Query: 78 NRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMH--EKGIIFN 135 R YG+ ++ + ++++ ++ + S F + + + + F Sbjct: 11 ARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQ--GSAFADRPSFASFRVVSGGRSMAFG 68 Query: 136 NNPELWKTTRPFFMKALSGP------GLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLT 189 + E WK R + + + + L + + ++D Sbjct: 69 HYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRP 128 Query: 190 L-LRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSV 248 L + V S F + ++ + + + + + + WL Sbjct: 129 LTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVR 188 Query: 249 KDLKD------AIEVLIAEKRRRISTE-EKLEECMDFATELILAEK----------RGDL 291 ++ I +K R D IL+ + L Sbjct: 189 TVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARL 248 Query: 292 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG-ERDIKIDDI 350 ENV I ++ A+ DT+S +L ++L L ++P+V+ + E+ V+G +R + D Sbjct: 249 DLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQ 308 Query: 351 QKLKVMENFIYESMRYQPVVDLVMRKALE-DDVIDGYPVKKGTNIILNIGR-MHRLEFFP 408 L + F+YE+MR+ V + + A + + GY + K T + +N H +P Sbjct: 309 PNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWP 368 Query: 409 KPNEFTLENF-------AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVK 461 P F F K++ R F G R C G+ ++ + + + L + + Sbjct: 369 NPENFDPARFLDKDGLINKDLTSRVMI-FSVGKRRCIGEELSKMQLFLFISILAHQCDFR 427 Query: 462 TLQGQCVESIQKIHDLSLHPDETKNMLEM 490 + + + + L++ P K + + Sbjct: 428 ANPNEPAK-MNFSYGLTIKPKSFKVNVTL 455 >3R9C-A nrPDB Length = 418 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 73/374 (19%), Positives = 129/374 (34%), Gaps = 42/374 (11%) Query: 96 IISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGP 155 ++ SS K + + ++ + G +F + P+ R KA + Sbjct: 63 VLRHPSSCSDRTKSTIFQRQLAAETQPRPQGP--ASFLFLDPPDH-TRLRGLVSKAFAPR 119 Query: 156 GLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVV 215 + R+ + LD ++ +++ L + L +P+++ Sbjct: 120 VIKRLEPEITALVDQLLDAVD-----GPEFNLIDNLAYPLPVAVICRLLGVPIEDEPKF- 173 Query: 216 KIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEEC 275 + AL + + S L+ + K+ L+D + LI E+RR Sbjct: 174 -SRASALLAAALDPFLALTGETSDLFDEQMKAGMWLRDYLRALIDERRRT--------PG 224 Query: 276 MDFATELILAEKRGD-LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIK 334 D + L+ E+ GD LT + + +LIA +T + + + P A+ Sbjct: 225 EDLMSGLVAVEESGDQLTEDEIIATCNLLLIAGHETTVNLIANAALAMLRTPGQWAALAA 284 Query: 335 EIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNI 394 + I E+MRY P V LV R A +D I + V KG + Sbjct: 285 DGSRA-----------------SAVIEETMRYDPPVQLVSRYAGDDLTIGTHTVPKGDTM 327 Query: 395 ILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVT 453 +L + HR P+ F + FG G C G +A + L Sbjct: 328 LLLLAAAHRDPTIVGAPDRFDPDR-----AQIRHLGFGKGAHFCLGAPLARLEATVALPA 382 Query: 454 LLRRFHVKTLQGQC 467 L RF L G+ Sbjct: 383 LAARFPEARLSGEP 396 >5L94-A nrPDB Length = 410 Score = 188 bits (477), Expect = 5e-48, Method: Composition-based stats. Identities = 63/328 (19%), Positives = 124/328 (37%), Gaps = 46/328 (14%) Query: 137 NPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVML 196 +P R KA + + A L +E + + +D++ L Sbjct: 88 DPPKHAEMRALVNKAFTPKAMKAWEPKIARITNELLQEVEHLED----IDIVEHLS---- 139 Query: 197 DTSNTLFLRIPLDESAIVVKIQGYFDAWQALL---IKPDIFFKISWLYKKYEKSVKDLKD 253 L + + D + ++ Q F W ++ + + L ++ K+ +L+ Sbjct: 140 ---YPLPVMVIADILGVPIEDQRQFKDWSDIIVAGPSNNERETLEKLQQEKMKANDELET 196 Query: 254 AIEVLIAEKRRRISTEEKLEECMDFATELILAEKRG-DLTRENVNQCILEMLIAAPDTMS 312 +I EKR R D + L+ A++ G LT E + + +LIA +T + Sbjct: 197 YFYRIIEEKRTR--------PGDDIISVLLQAKEEGKQLTDEEIVGFSILLLIAGNETTT 248 Query: 313 VSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDL 372 + ++ + + E + +E + ++ + I E +RY+ V Sbjct: 249 NLISNTIYCLMEDKASFERLKREKE-----------------LLPSGIEEVLRYRSPVQA 291 Query: 373 VMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENFAKNVPYRYFQPFG 431 + R ED + G +K G +++ +G HR E+F P F ++ FG Sbjct: 292 LHRIVKEDVTLAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFKIDR-----KPNVHMAFG 346 Query: 432 FGPRGCAGKYIAMVMMKAILVTLLRRFH 459 G C G +A + K +L L+ R+ Sbjct: 347 RGIHFCLGAPLARIEAKIMLAELIDRYP 374 >5OFQ-A nrPDB Length = 409 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 66/370 (17%), Positives = 138/370 (37%), Gaps = 50/370 (13%) Query: 116 FGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRL 175 F SK ++ ++ I+ + P+ K R KA + + + E LD + Sbjct: 70 FSSKRAME---ERQESILMMDPPKHTK-LRNLVNKAFTPRAIQHLEGHIEEIADYLLDEV 125 Query: 176 EEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIK---PD 232 D++ D + L + + + + ++ + F + L+ + Sbjct: 126 SSKEK----FDIVE-------DFAGPLPIIVIAELLGVPIQDRALFKKYSDDLVSGAENN 174 Query: 233 IFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD-L 291 + + +K + V L+ + +IAE+++ D + L+ AE G+ L Sbjct: 175 SDEAFAKMMQKRNEGVIFLQGYFKEIIAERQQNKQE--------DLISLLLEAEIDGEHL 226 Query: 292 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQ 351 T E V + +L+A +T + + + + + +V+ + ++I Sbjct: 227 TEEEVLGFCILLLVAGNETTTNLITNGVRYMTEDVDVQNEVRRDIS-------------- 272 Query: 352 KLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEF-FPKP 410 ++ N + E++RY P + + R A ED + +K+G +I +R F P Sbjct: 273 ---LVPNLVEETLRYYPPIQAIGRIAAEDVELGECKIKRGQQVISWAASANRDSAKFEWP 329 Query: 411 NEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVES 470 + F + FGFG C G +A + K LL + +Q Q ++ Sbjct: 330 DTFVVHRKTNP-----HVSFGFGIHFCLGAPLARMEGKIAFTKLLEKGGFSKVQNQSLKP 384 Query: 471 IQKIHDLSLH 480 I + Sbjct: 385 IDSPFVFGVK 394 >2ZQJ-A nrPDB Length = 417 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 67/344 (19%), Positives = 125/344 (36%), Gaps = 38/344 (11%) Query: 142 KTTRP-FFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSN 200 R F+ ++ P R+ + E K + R E+ + + +L RV Sbjct: 92 HIHRKMLFLSLMTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVA----- 146 Query: 201 TLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIA 260 + +PL E+ + + + D D F + + K ++ ++ IEV+I Sbjct: 147 CYWAGVPLKETEVKERADDFIDM-------VDAFGAVGPRHWKGRRARPRAEEWIEVMIE 199 Query: 261 EKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLF 320 + R + K ++ G +E++ +++S F + Sbjct: 200 DARAGLL---KTTSGTALHEMAFHTQEDGSQLDS--RMAAIELINVLRPIVAISYFLVFS 254 Query: 321 LIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALED 380 +A H E KE R+ E F+ E RY P + +D Sbjct: 255 ALALH---EHPKYKEWLRSGNSRE-----------REMFVQEVRRYYPFGPFLGALVKKD 300 Query: 381 DVIDGYPVKKGTNIILNIG-RMHRLEFFPKPNEFTLENFAKNVPYRY-FQPFGFGP---- 434 V + KKGT+++L++ H + P+EF E FA+ + P G G Sbjct: 301 FVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEFRPERFAEREENLFDMIPQGGGHAEKG 360 Query: 435 RGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLS 478 C G+ I + +MKA L L+ + + S+ ++ L Sbjct: 361 HRCPGEGITIEVMKASLDFLVHQIEYDVPEQSLHYSLARMPSLP 404 >2WX2-A nrPDB Length = 473 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 66/445 (14%), Positives = 152/445 (34%), Gaps = 29/445 (6%) Query: 50 PGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKH 109 P +G ++ G+ C + + I G+ I+ Sbjct: 22 PVTVPFLGHIVQFGKNPLEF-MQRCKRDLK--SGVFTISIGGQRVTIVGDPHEHSRFFSP 78 Query: 110 NHYSSRFGSKLGLQCIGM-HEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESL 168 + + + +G+ + + F + L+ V + Sbjct: 79 R--NEILSPREVYTIMTPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEV 136 Query: 169 KT-HLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQAL 227 + + +E G +++L ++++T+ L + ++ Sbjct: 137 RKFMAENWKED---EGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSKMESS 193 Query: 228 LIKPDIFFKISWLYK-------KYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFAT 280 LI +F + WL + + ++ +L+ + +I + + ++++ + Sbjct: 194 LIPAAVF--MPWLLRLPLPQSARCREARAELQKILGEIIVAREKEEASKDNNTSDLLGGL 251 Query: 281 ELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAK--HPNVEEAIIKEIQT 338 + ++ V I+ + A T +++ + + + + + + KEI Sbjct: 252 LKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDE 311 Query: 339 VIGERDIKIDDIQK-LKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILN 397 + D++ + E + ES+R P + +VMR + + Y V KG I + Sbjct: 312 F--PAQLNYDNVMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACS 369 Query: 398 -IGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLR 456 + H E FP P + E F FG G C G+ A++ +K IL T R Sbjct: 370 PLLSHHDEEAFPNPRLWDPER--DEKVDGAFIGFGAGVHKCIGQKFALLQVKTILATAFR 427 Query: 457 RFHVKTLQGQCVESIQKIHDLSLHP 481 + + L+ + V H + + P Sbjct: 428 EYDFQLLRDE-VPD-PDYHTMVVGP 450 >4UBS-A nrPDB Length = 393 Score = 185 bits (469), Expect = 4e-47, Method: Composition-based stats. Identities = 72/421 (17%), Positives = 141/421 (33%), Gaps = 65/421 (15%) Query: 83 EFMRVW-ISGEETLIISKSSSMFHIMKHNHYSSRFGSKL------GLQCIGMHEKGIIFN 135 RV G +++ ++ ++ SS + + ++ Sbjct: 27 PLSRVSLYDGRSVWVVTGHAAARALLSDQRLSSDRTLPRFPATTERFEAVRTRRVALLGV 86 Query: 136 NNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVM 195 ++PE +T R + + + + E++ LD +E + V L Sbjct: 87 DDPEH-RTQRRMLVPSFTLKRAAALRPRIQETVDGLLDAMEAQGPPAELVSAFAL----- 140 Query: 196 LDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAI 255 L + + +F++ L++ + + + L D + Sbjct: 141 -----PLPSMVICALLGVPYADHDFFESQSRRLLR-------GPGIAEVQDARAQLDDYL 188 Query: 256 EVLIAEKRRRISTEEKLEECMDFATELILAE-KRGDLTRENVNQCILEMLIAAPDTMSVS 314 LI KR+ E +LI + RG + R + +LIA +T + Sbjct: 189 YALIDRKRK--------EPGDGLLDDLIQEQLNRGTVDRAELVSLATLLLIAGHETTANM 240 Query: 315 LFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVM 374 + F + +HP + E +M + E +R+ + D ++ Sbjct: 241 ISLGTFTLLRHPEQLAELRAEPG-----------------LMPAAVEELLRFLSIADGLL 283 Query: 375 RKALEDDVIDGYPVKKGTNIILNIGRMHRLEF-FPKPNEFTLENFAKNVPYRYFQPFGFG 433 R A ED + G ++ ++ ++R F +P+ A R+ FGFG Sbjct: 284 RVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALDWHRSA-----RHHVAFGFG 338 Query: 434 PRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDET-KNMLEMIF 492 C G+ +A M+ L TL R L E + P +T + MLE+ Sbjct: 339 IHQCLGQNLARAEMEIALGTLFERLPGLRLAAPADE-------IPFKPGDTIQGMLELPV 391 Query: 493 T 493 T Sbjct: 392 T 392 >3L4D-A nrPDB Length = 453 Score = 184 bits (466), Expect = 8e-47, Method: Composition-based stats. Identities = 72/458 (15%), Positives = 159/458 (34%), Gaps = 38/458 (8%) Query: 51 GYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHN 110 G +G +I G+ + A + YG + I G ++ H Sbjct: 10 GTTPFVGHIIQFGKDPLGFMLKA----KKKYGGIFTMNICGNRITVVGD--------VHQ 57 Query: 111 HYSSRFGSKLGLQC-------IGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTV 163 H L + + +G+ + + F + L+ Sbjct: 58 HSKFFTPRNEILSPREVYSFMVPVFGEGVAYAAPYPRMREQLNFLAEELTVAKFQNFAPS 117 Query: 164 CAESLKTHLDRLEEVTNES-GYVDVLTLLRRVMLDTSNTLFLRIPL-DESAIVVKIQGYF 221 ++ ++ N+ G +++L ++++T+ L Q Sbjct: 118 IQHEVRKF---MKANWNKDEGEINILDDCSAMIINTACQCLFGEDLRKRLDARQFAQLLA 174 Query: 222 DAWQALLIKPDIFFKISWLY----KKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMD 277 L+ I L + + +L+D + +I + + + ++ + Sbjct: 175 KMESCLIPAAVFLPWILKLPLPQSYRCRDARAELQDILSEIIIAREKEEAQKDTNTSDLL 234 Query: 278 FATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIA--KHPNVEEAIIKE 335 + +++ V I+ + A T +++ + L + ++ + +E Sbjct: 235 AGLLGAVYRDGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLHQE 294 Query: 336 IQTVIGERDIKIDDI-QKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNI 394 I + D++ +++ E ES+R P + ++MRK L+ + Y V +G I Sbjct: 295 IDEF--PAQLNYDNVMEEMPFAEQCARESIRRDPPLVMLMRKVLKPVQVGKYVVPEGDII 352 Query: 395 ILNIGRMH-RLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVT 453 + H E FP P E+ E K V F FG G C G+ ++ +K +L T Sbjct: 353 ACSPLLSHQDEEAFPNPREWNPERNMKLVD-GAFCGFGAGVHKCIGEKFGLLQVKTVLAT 411 Query: 454 LLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMI 491 +LR + + L + H + + P ++ ++ I Sbjct: 412 VLRDYDFELL--GPLPE-PNYHTMVVGPTASQCRVKYI 446 >3EJB-B nrPDB Length = 404 Score = 180 bits (457), Expect = 1e-45, Method: Composition-based stats. Identities = 60/387 (15%), Positives = 123/387 (31%), Gaps = 47/387 (12%) Query: 83 EFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFG----SKLGLQCIGMHEKGIIFNNNP 138 + ++ I+K + R S + + ++F N P Sbjct: 27 PIYKGSFLKYPGWYVTGYEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQP 86 Query: 139 ELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDT 198 + + R A + E++ LD+++ V+ D Sbjct: 87 DH-RRLRTLASGAFTPRTTESYQPYIIETVHHLLDQVQGKKKM-----------EVISDF 134 Query: 199 SNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVL 258 + L + + + + + W A LI+ F + + + L Sbjct: 135 AFPLASFVIANIIGVPEEDREQLKEWAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKEL 194 Query: 259 IAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFM 318 I +++R D + L+ ++ LT E + + IA +T + Sbjct: 195 IQKRKR--------HPQQDMISMLLKGREKDKLTEEEAASTCILLAIAGHETTVNLISNS 246 Query: 319 LFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKAL 378 + + +HP + + ++ + E +RY+ + R A Sbjct: 247 VLCLLQHPEQLLKLRENPD-----------------LIGTAVEECLRYESPTQMTARVAS 289 Query: 379 EDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGC 437 ED I G +++G + L +G +R F P+ F + FG G C Sbjct: 290 EDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP-----HLSFGHGHHVC 344 Query: 438 AGKYIAMVMMKAILVTLLRRFHVKTLQ 464 G +A + + + TLL+R L Sbjct: 345 LGSSLARLEAQIAINTLLQRMPSLNLA 371 >2X2N-A nrPDB Length = 475 Score = 177 bits (449), Expect = 9e-45, Method: Composition-based stats. Identities = 69/452 (15%), Positives = 159/452 (35%), Gaps = 23/452 (5%) Query: 50 PGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKH 109 P +G +I G+ +G C + + I G+ I+ Sbjct: 22 PVTVPILGHIIQFGKSP-LGFMQECKRQLK--SGIFTINIVGKRVTIVGDPHEHSRFFLP 78 Query: 110 NHYSSRFGSKLGLQ-CIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESL 168 + + + + +G+ + + F + L+ V + Sbjct: 79 R--NEVLSPREVYSFMVPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEV 136 Query: 169 KTHLDRLEEVTNES-GYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQAL 227 + + ++ G +++L ++++T+ L + + ++ Sbjct: 137 RKF---MAANWDKDEGEINLLEDCSTMIINTACQCLFGEDLRKRLDARRFAQLLAKMESS 193 Query: 228 LIKPDIFFKISWLYKKYE-----KSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATEL 282 LI +F I + ++ +L+ + +I ++ ++ + Sbjct: 194 LIPAAVFLPILLKLPLPQSARCHEARTELQKILSEIIIARKAAAVNKDSSTSDLLSGLLS 253 Query: 283 ILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAK--HPNVEEAIIKEIQTVI 340 + ++ V I+ + A T S++ + + + + EA+ KEI+ Sbjct: 254 AVYRDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEE-F 312 Query: 341 GERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILN-IG 399 + + + ++ E ES+R P + ++MRK + D + Y V KG I + + Sbjct: 313 PAQLNYNNVMDEMPFAERCARESIRRDPPLLMLMRKVMADVKVGSYVVPKGDIIACSPLL 372 Query: 400 RMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFH 459 H E FP+P + E F FG G C G+ ++ +K IL T R + Sbjct: 373 SHHDEEAFPEPRRWDPER--DEKVEGAFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYD 430 Query: 460 VKTLQGQCVESIQKIHDLSLHPDETKNMLEMI 491 + L+ + V H + + P ++ ++ I Sbjct: 431 FQLLRDE-VPD-PDYHTMVVGPTASQCRVKYI 460 >4YZR-A nrPDB Length = 405 Score = 176 bits (447), Expect = 2e-44, Method: Composition-based stats. Identities = 71/412 (17%), Positives = 146/412 (35%), Gaps = 53/412 (12%) Query: 74 CNYYNRVYGEFMRVWISGEE--TLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKG 131 + + +G W+ + K + + +K+ + + I Sbjct: 31 HRFELKRFGATYPAWLITRYDDCMAFLKDNRITRDVKNVMNQEQIKMLNVSEDIDFVSDH 90 Query: 132 IIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLL 191 ++ + P+ R +A + + + + + LD +E+ Sbjct: 91 MLAKDTPDH-TRLRSLVHQAFTPRTIENLRGSIEQIAEQLLDEMEKENK----------- 138 Query: 192 RRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDL 251 +M ++ L + + I + + F W + D L +++++ Sbjct: 139 ADIMKSFASPLPFIVISELMGIPKEDRSQFQIWTNAM--VDTSEGNRELT---NQALREF 193 Query: 252 KDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRG-DLTRENVNQCILEMLIAAPDT 310 KD I LI ++R ++ D ++L+ AE+ G L+ + + + +++A +T Sbjct: 194 KDYIAKLIHDRR--------IKPKDDLISKLVHAEENGSKLSEKELYSMLFLLVVAGLET 245 Query: 311 MSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRY-QPV 369 L + +H E + Q+ +++ + E +RY PV Sbjct: 246 TVNLLGSGTLALLQHKKECEKL-----------------KQQPEMIATAVEELLRYTSPV 288 Query: 370 VDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYFQ 428 V + R A+ED G+ +K+G I + IG +R FF P + Sbjct: 289 VMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEILNINRSPNR-----HI 343 Query: 429 PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480 FGFG C G +A + LL+RF L + IQ ++ L Sbjct: 344 SFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAP-DDIQWRKNVFLR 394 >4OQS-A nrPDB Length = 433 Score = 176 bits (445), Expect = 2e-44, Method: Composition-based stats. Identities = 68/381 (17%), Positives = 125/381 (32%), Gaps = 66/381 (17%) Query: 96 IISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWK---------TTRP 146 +++ ++ +M +S+R K + + G W R Sbjct: 49 LVTSHAAARTVMIDPRFSNRPEHKHPVFSVIPRPGG-ATKAPAPGWFINMDAPEHTRYRR 107 Query: 147 FFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRI 206 + + + + + + HLD + + V L + + Sbjct: 108 MLISQFTVRRIKELEPRIVQITEDHLDAMAKAGPPVDLVQAFAL----------PVPSLV 157 Query: 207 PLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRI 266 + + +F ++ D + ++ L I L+A KR Sbjct: 158 ICELLGVSYADHAFFQEQTTIMASVD------KTQDEVTTALGKLTRYIAELVATKR--- 208 Query: 267 STEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHP 326 L D LI DLT E + L +L+A +T + L F + +HP Sbjct: 209 -----LSPKDDLLGSLI---TDTDLTDEELTNIALLLLVAGHETTANMLGLGTFALLQHP 260 Query: 327 NVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVM--RKALEDDVID 384 A+ + + E +RY +V L R ALED ++ Sbjct: 261 EQIAALDS----------------------PDAVEELLRYLSIVHLGTPNRAALEDVELE 298 Query: 385 GYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIA 443 G ++KG + + + ++R + F +P+ L+ V R FG G C G+ +A Sbjct: 299 GQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDR----VDARKHAAFGGGIHQCLGQQLA 354 Query: 444 MVMMKAILVTLLRRFHVKTLQ 464 V M+ L RF L Sbjct: 355 RVEMRIGFTRLFARFPSLRLA 375 >4RM4-A nrPDB Length = 396 Score = 174 bits (442), Expect = 6e-44, Method: Composition-based stats. Identities = 61/329 (18%), Positives = 124/329 (37%), Gaps = 40/329 (12%) Query: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLR 192 I N +P R KA + + + E + +++ S + Sbjct: 81 IINMDPPKHTKIRSVVNKAFTPRVMKQWEPRIQEITD---ELIQKFQGRSEF-------- 129 Query: 193 RVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLK 252 ++ D S L + + + + F AW LL+ ++ EK+ + + Sbjct: 130 DLVHDFSYPLPVIVISELLGVPSAHMEQFKAWSDLLVSTP-----KDKSEEAEKAFLEER 184 Query: 253 DAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAAPDTM 311 D E +A I E++ + D + L+ AE+ G+ L+ E + +L+A +T Sbjct: 185 DKCEEELAAFFAGIIEEKRNKPEQDIISILVEAEETGEKLSGEELIPFCTLLLVAGNETT 244 Query: 312 SVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVD 371 + + ++ I + P V E + ++M + E++R++ Sbjct: 245 TNLISNAMYSILETPGVYEEL-----------------RSHPELMPQAVEEALRFRAPAP 287 Query: 372 LVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEF-FPKPNEFTLENFAKNVPYRYFQPF 430 ++ R A D I G+ +K+G ++ + +R E F +P+ F + F Sbjct: 288 VLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRRHPNP-----HIAF 342 Query: 431 GFGPRGCAGKYIAMVMMKAILVTLLRRFH 459 G G C G +A + L +L+ F Sbjct: 343 GHGIHFCLGAPLARLEANIALTSLISAFP 371 >4OQR-A nrPDB Length = 457 Score = 174 bits (441), Expect = 7e-44, Method: Composition-based stats. Identities = 67/381 (17%), Positives = 124/381 (32%), Gaps = 66/381 (17%) Query: 96 IISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWK---------TTRP 146 +++ ++ +M +S+R K + + G W R Sbjct: 88 LVTSHAAARTVMIDPRFSNRPEHKHPVFSVIPRPGG-ATKAPAPGWFTNMDAPEHTRYRR 146 Query: 147 FFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRI 206 + + + + + HLD + + V L + + Sbjct: 147 MLISQFTVRRIKELEPRIVRITEDHLDAMAKAGPPVDLVQAFAL----------PVPSLV 196 Query: 207 PLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRI 266 + + +F +++ D + ++ L I L+A KR Sbjct: 197 ICELLGVSYADHAFFQEQTTIMVSVD------KTQDEVTTALGKLTRYIAELVATKR--- 247 Query: 267 STEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHP 326 L D LI DLT E + L +L+A +T + L F + +HP Sbjct: 248 -----LSPKDDLLGSLI---TDTDLTDEELTNIALILLVAGHETTANMLGLGTFALLQHP 299 Query: 327 NVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVM--RKALEDDVID 384 + + + E +RY +V L R ALED ++ Sbjct: 300 EQIANLDS----------------------PDAVEELLRYLSIVHLGTPNRAALEDVELE 337 Query: 385 GYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIA 443 G ++KG + + + ++R + F +P+ L+ V R FG G C G+ +A Sbjct: 338 GQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDR----VDARKHAAFGGGIHQCLGQQLA 393 Query: 444 MVMMKAILVTLLRRFHVKTLQ 464 V M+ L RF L Sbjct: 394 RVEMRIGFTRLFARFPSLRLA 414 >6GK6-A nrPDB Length = 411 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 62/350 (17%), Positives = 131/350 (37%), Gaps = 52/350 (14%) Query: 127 MHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVD 186 ++ ++ + P+ R +A S + + R++E+ + G +D Sbjct: 86 FMDQHMLDADPPDH-TRLRAIVQRAFSPRMMEGLRP-----------RIQEIAD--GLID 131 Query: 187 VLTLLRRVML--DTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKY 244 + RR+ L D + L + + + V+ +G F W +L+ P K ++ Sbjct: 132 AVIDRRRMELIADFAFPLPTAVIAELLGLPVEDRGRFRRWTKILLAP---AKDREFVERA 188 Query: 245 EKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEM 303 + V++ L +R+ D + L+LAE++ L+ ++ + + Sbjct: 189 QPVVEEFAAYFRALADARRKA--------PRDDLISGLLLAEEQEHKLSPAELSSMVFLL 240 Query: 304 LIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYES 363 L+A +T + + L+ HP + ++ ++ + + E+ Sbjct: 241 LVAGHETTVHLIASGMLLLLSHPAERRRLDEDPG-----------------LVGSAVEEA 283 Query: 364 MRYQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKN 421 +R + +L +R +LED + G V G + + +R + FP P+ F + Sbjct: 284 LRCEGPAELSTIRWSLEDIELFGARVPAGEGVAAGLLAANRDPQHFPDPDRFDIGRSPNR 343 Query: 422 VPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESI 471 FG G C G +A + TLLRR L + + Sbjct: 344 -----HIGFGGGIHFCLGAMLARIEAAIAFSTLLRRLPRIELATSTRDIV 388 >1EHE-A nrPDB Length = 403 Score = 173 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 59/373 (15%), Positives = 126/373 (33%), Gaps = 51/373 (13%) Query: 96 IISKSSSMFHIMKHNHYSSR-----FGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMK 150 +++K + + S F K + +P R Sbjct: 44 LVTKHKDVCFVATSEKLSKVRTRQGFPELSASGKQAAKAKPTFVDMDPPEHMHQRSMVEP 103 Query: 151 ALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDE 210 + + + ++ L+++++ +G VD++ + L +P ++ Sbjct: 104 TFTPEAVKNLQPYIQRTVDDLLEQMKQKGCANGPVDLVKEFALPVPSYIIYTLLGVPFND 163 Query: 211 SAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEE 270 + + S ++ + ++L D + +L+ E+ Sbjct: 164 LEYLTQQNAIRTNG-------------SSTAREASAANQELLDYLAILV---------EQ 201 Query: 271 KLEECMDFATELILAEK--RGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNV 328 +L E D + E+ G++ + + Q +L+A TM + + +A+HP+ Sbjct: 202 RLVEPKDDIISKLCTEQVKPGNIDKSDAVQIAFLLLVAGNATMVNMIALGVATLAQHPDQ 261 Query: 329 EEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVM-RKALEDDVIDGYP 387 + + F+ E RY L + R A ED +I Sbjct: 262 LAQL-----------------KANPSLAPQFVEELCRYHTASALAIKRTAKEDVMIGDKL 304 Query: 388 VKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVM 446 V+ II + +R E F P+EF + P + FGFG C +++A Sbjct: 305 VRANEGIIASNQSANRDEEVFENPDEFNMNR---KWPPQDPLGFGFGDHRCIAEHLAKAE 361 Query: 447 MKAILVTLLRRFH 459 + + TL ++F Sbjct: 362 LTTVFSTLYQKFP 374 >3WEC-A nrPDB Length = 419 Score = 172 bits (435), Expect = 4e-43, Method: Composition-based stats. Identities = 72/406 (17%), Positives = 135/406 (33%), Gaps = 66/406 (16%) Query: 96 IISKSSSMFHIMKHNHYSSRFGSKLGLQ-CIGMHEKGI--------------IFNNNPEL 140 I++ +S +++ + F + M + + +P Sbjct: 48 IVADYTSCDKVLRSRLFGKDFANSTFFDHLTSMMGEDMPPFLGLGIDGDARPFMLTDPPE 107 Query: 141 WKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSN 200 R A + M + + + + LE T+ V + Sbjct: 108 HTRLRGLVSDAFTRSTTTSMDDIVLSAASSAVRHLEHCTDAVSEV-------------AE 154 Query: 201 TLFLRIPLDESAIVVKIQGYFDAWQALLIKP-DIFFKISWLYKKYEKSVKDLKDAIEVLI 259 + + I K +G F W L+ DI F I K V D + A Sbjct: 155 PFPVEVLSSILGIPDKDRGRFSEWSNLVAGVLDINFAIP-------KEVADRRSAAIEES 207 Query: 260 AEKRRRISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAAPDTMSVSLFFM 318 + R ++T E L GD L+ + + L + +A +T S ++ M Sbjct: 208 IDYFRTLATSGNAPEG--LVRRLSEVSHGGDQLSVDEIAATCLLITVAGQETTSNTIGNM 265 Query: 319 LFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKAL 378 L ++H + E + + +EN + E +R++P R AL Sbjct: 266 LITFSRHADQFEQV-----------------RANPQFIENAVAEVLRFEPPAHEAGRIAL 308 Query: 379 EDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCA 438 ED + G + KG +++ + +R E + + F++ P +G G C Sbjct: 309 EDCEVSGANITKGDAVMVLLASGNR-EAVERGDTFSVTR-----PDVSSLSYGRGIHHCL 362 Query: 439 GKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDET 484 G +A M++ L L +R+ + E I + L ET Sbjct: 363 GSALANSMLQHFLRELSQRYRSIEVA----EPINYKPGMGLRGPET 404 >5VWS-A nrPDB Length = 393 Score = 171 bits (434), Expect = 4e-43, Method: Composition-based stats. Identities = 59/337 (17%), Positives = 103/337 (30%), Gaps = 46/337 (13%) Query: 126 GMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYV 185 G + GI + PE R A + + M + LD L Sbjct: 72 GFGKGGITMIDPPEHRH-QRRLITHAFTPQSISAMEPRIRQIADHLLDEL-----PGPEF 125 Query: 186 DVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDI-FFKISWLYKKY 244 D++ + L + + + + + F W L+ + + L + Sbjct: 126 DLVE-------HFAYPLPVIVIAELLGVPPGDRHLFRTWSDRLMSLQVENYADPELARTV 178 Query: 245 EKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEM 303 ++ ++ D + R + D T L+ AE G L E V + Sbjct: 179 AAAMTEMNDYL--------REHCRSRRTHPRDDLLTRLVQAEVEGKRLDLEEVVNTASLL 230 Query: 304 LIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYES 363 L+A T +V + + + HP E+A+ ++ + ES Sbjct: 231 LLAGHLTTTVLIGNTMLCLWDHPEAEKAV-----------------RADPSLIPAALEES 273 Query: 364 MRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILN-IGRMHRLEFFPKPNEFTLENFAKNV 422 +R + R D I G + ++ + H FP P F L Sbjct: 274 LRLRSPFLQAGRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPERFDLHRQTTG- 332 Query: 423 PYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFH 459 FG G C G + + + L LL RF Sbjct: 333 ----HIAFGHGVHFCLGAQLGRLEGRIALERLLGRFT 365 >5FOI-A nrPDB Length = 408 Score = 170 bits (431), Expect = 1e-42, Method: Composition-based stats. Identities = 68/417 (16%), Positives = 147/417 (35%), Gaps = 61/417 (14%) Query: 63 GRFLWMGIGSACNYYNRVYGEF--------MRVWISGEETLIISKSSSMFHIMKHNHYSS 114 +W + Y EF +VW G T ++S+ + ++ + Sbjct: 20 HMVVWPMDRTCAWALPEQYAEFRQRATLVPAKVW-DGSPTWLVSRYEHVRALLVDPRVTV 78 Query: 115 RFGSKLGL---QCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTH 171 + L G + ++ + PE R F+ A S + M + + Sbjct: 79 DPTRQPRLSEADGDGDGFRSMLMLDPPEH-TRLRRMFISAFSVRQVETMRPEIEKIVDGI 137 Query: 172 LDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKP 231 LDRL + + +L + L + ++ + + + +F L +P Sbjct: 138 LDRLLALEPP------VDILTHLAL----PMSTQVICHLLGVPYEDREFFQERSELASRP 187 Query: 232 DIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDL 291 + + ++ +L + ++ L+ K T T + +G++ Sbjct: 188 ND--------DRSMPALIELVEYLDGLVRTKTAHPDTG-------LLGTAVTERLLKGEI 232 Query: 292 TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQ 351 T + + + +L A +T + + + + +HP + + Sbjct: 233 THQELVNNAVLLLAAGHETSANQVTLSVLTLLRHPETAAELRE----------------- 275 Query: 352 KLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKP 410 + ++M N + E +RY + D + R A D V+ + ++ G +I+ + + F Sbjct: 276 QPELMPNAVDELLRYHSIADGLRRAATADIVLGDHTIRAGDGLIILLSSANHDGNTFGAE 335 Query: 411 NEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQC 467 F + P R+ FG+GP C G+ +A + M+ L L RR L + Sbjct: 336 ATFDIHR-----PARHHVAFGYGPHQCLGQNLARLEMEVTLGKLFRRVPALRLAQEP 387 >5Y1I-A nrPDB Length = 403 Score = 170 bits (430), Expect = 1e-42, Method: Composition-based stats. Identities = 70/418 (16%), Positives = 143/418 (34%), Gaps = 62/418 (14%) Query: 86 RVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFN-------NNP 138 R+W G ++++ + ++ S G + G I K + ++P Sbjct: 37 RIW-DGSTPWVVTRHADQRALLSDPRVSHD-GLRDGYPHISADFKFLSMAQPSFAGQDDP 94 Query: 139 ELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDT 198 E R + + M + +D + V+ L L Sbjct: 95 EH-GRIRRMVTLPFTARRIEAMRPAIQKITDELIDGMLAGPKPVDLVEALAL-------- 145 Query: 199 SNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVL 258 + +R+ + + + + + +I D +K+ ++ L Sbjct: 146 --PVPVRVICEMLGVPYEDREFLQQNNNAMIYRDTA------QGDAQKAAIAQAMYLKEL 197 Query: 259 IAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFM 318 + K + D ++L + + G++T+++ + +L A +T + + Sbjct: 198 VGTKLG--------DRGDDILSDLAVQVEAGEITQDDAAGIGMMLLGAGHETTANMIALG 249 Query: 319 LFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVD-LVMRKA 377 + ++P + D KV+ N + E +RY + V R A Sbjct: 250 TLALLENPEQLAEVR---------------DSDDPKVIVNTVEELLRYLTIAQDTVRRIA 294 Query: 378 LEDDVIDGYPVKKGTNIILNIGRMH-RLEFFPK-PNEFTLENFAKNVPYRYFQPFGFGPR 435 ED I G +K G I+ + + + +P+ P+ + R FG+G Sbjct: 295 AEDIEIGGVVIKAGEGIVFPLNAANWDPDLYPEAPDRLDIHR----ANARRHLAFGYGVH 350 Query: 436 GCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFT 493 C G +A V ++ + TLLRR L G ++ I HD H + E+ T Sbjct: 351 QCLGATLARVELQIVYSTLLRRIPTLALAG-TLDEIPFKHDQIAH-----GVYELPVT 402 >6M7X-A nrPDB Length = 484 Score = 169 bits (427), Expect = 4e-42, Method: Composition-based stats. Identities = 79/435 (18%), Positives = 165/435 (37%), Gaps = 38/435 (8%) Query: 82 GEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCI------GMHEKGIIFN 135 G R + G + + + + S ++ L+ H+ G+ Sbjct: 53 GPIFRYDLGGAGMVCVMLPEDVEKL---QQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLL 109 Query: 136 NNPELWKTTR-PFFMKALSGPGLVRMVTVCAESLKTHLDRLEEV----TNESGYVDVLTL 190 N PE W+ R + LS + R + + + L++ S +DV Sbjct: 110 NGPE-WRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPS 168 Query: 191 LRRVMLDTSNTLFLRIPLDESAI---------VVKIQGYFDAWQALLIKPDIFFK--ISW 239 + ++ SN L + ++ F + L+ P + Sbjct: 169 IFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPK 228 Query: 240 LYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQC 299 ++K++ ++ + + I + + ++ ++ EL+L +L+ + + Sbjct: 229 VWKEHFEAWDCIFQYGDNCIQKIYQELAFSR-PQQYTSIVAELLL---NAELSPDAIKAN 284 Query: 300 ILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE-RDIKIDDIQKLKVMEN 358 +E+ + DT L LF +A++PNV++A+ +E + +L ++ Sbjct: 285 SMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRA 344 Query: 359 FIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLEN 417 + E++R PV + R A D V+ Y + GT + + + + R FP+P + + Sbjct: 345 ALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQR 404 Query: 418 FAK---NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKI 474 + + Y PFGFG R C G+ +A M +L +L+ V+TL E I+ + Sbjct: 405 WLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETL---TQEDIKMV 461 Query: 475 HDLSLHPDETKNMLE 489 + L P + Sbjct: 462 YSFILRPSMFPLLTF 476 >5EX6-C nrPDB Length = 434 Score = 168 bits (426), Expect = 4e-42, Method: Composition-based stats. Identities = 62/398 (15%), Positives = 134/398 (33%), Gaps = 64/398 (16%) Query: 82 GEFMRVWISG----EETLIISKSSSMFHIM-KHNHYSSR--------FGSKLGLQCIGMH 128 GE RV + E T + + + ++ H +S+R G K + + Sbjct: 62 GELTRVRLGSGADAEHTWLATGHDVVRQVLGDHTRFSTRRRFDRNDEIGGKGVFRPRELV 121 Query: 129 EKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVL 188 + ++ R + + RM + +RL+E+ E D++ Sbjct: 122 GNLMDYDPPEHT--RLRRLLAPGFTHRKIRRMAPYIEQ---IVTERLDEMEREGSPADLI 176 Query: 189 TLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSV 248 L + L +P D+ A+ +++ S ++ + Sbjct: 177 ELFADEVPGPVLCELLGVPRDDRAMFLQLCHR-------------HLDASLSGRRRAAAG 223 Query: 249 KDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAP 308 + + ++A +R+ + D +++AE +T E + ++M++A Sbjct: 224 EAFSRYLVTMVARERK---------DPGDGLIGMVVAEHGDTVTDEELRGVCVQMMLAGD 274 Query: 309 DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQP 368 D +S + + + ++P A+ ++ E + E +RY Sbjct: 275 DNISGMIGLGVLALLRNPEQIAALRGDV-----------------PAAERAVDELIRYLT 317 Query: 369 -VVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRY 426 R A+ED + +K G ++ ++ +R P + + A Sbjct: 318 VPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDADRLDVTREAVP----- 372 Query: 427 FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQ 464 FG G C G +A + ++ L RRF L Sbjct: 373 HVAFGHGVHHCLGAALARLELRIAYTALWRRFPDLRLA 410 >4ZGX-A nrPDB Length = 489 Score = 167 bits (423), Expect = 1e-41, Method: Composition-based stats. Identities = 83/479 (17%), Positives = 174/479 (36%), Gaps = 41/479 (8%) Query: 38 VWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLII 97 V +E PG + + I + + + G R + G + + Sbjct: 12 VLPFEAMPQHPGNRWLRLLQ--IWREQGYEHLHLEMHQTFQEL-GPIFRYNLGGPRMVCV 68 Query: 98 SKSSSMFHIMKHNHYSSRFGSKLGLQCI------GMHEKGIIFNNNPELWKTTR-PFFMK 150 + + S ++ L+ H+ G+ N PE W+ R Sbjct: 69 MLPEDVEKL---QQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPE-WRFNRLRLNPD 124 Query: 151 ALSGPGLVRMVTVCAESLKTHLDRLEEV----TNESGYVDVLTLLRRVMLDTSNTLFLRI 206 LS + R + + + L++ S +DV + ++ SN Sbjct: 125 VLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGE 184 Query: 207 PLDESAI---------VVKIQGYFDAWQALLIKPDIFFK--ISWLYKKYEKSVKDLKDAI 255 L + ++ F + L+ P + ++K++ ++ + Sbjct: 185 RLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYG 244 Query: 256 EVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSL 315 + I + + ++ A L+ AE L+ E + +E+ + DT + L Sbjct: 245 DNCIQKIYQELAFNRPQHYTGIVAELLLKAE----LSLEAIKANSMELTAGSVDTTAFPL 300 Query: 316 FFMLFLIAKHPNVEEAIIKEIQTVIGE-RDIKIDDIQKLKVMENFIYESMRYQPVVDLVM 374 LF +A++P+V++ + +E + +L ++ + E++R PV + Sbjct: 301 LMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLE 360 Query: 375 RKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENFAK---NVPYRYFQPF 430 R D V+ Y + GT + + + + R FP+P + + + + + PF Sbjct: 361 RVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPF 420 Query: 431 GFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLE 489 GFG R C G+ +A M +L +L+ F V+TL E I+ ++ L P + + Sbjct: 421 GFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETL---TQEDIKMVYSFILRPGTSPLLTF 476 >4JBT-A nrPDB Length = 410 Score = 166 bits (421), Expect = 2e-41, Method: Composition-based stats. Identities = 68/421 (16%), Positives = 136/421 (32%), Gaps = 65/421 (15%) Query: 82 GEFMRVWISGEETLIISKSSSMFHIMKHNHY-----------SSRFGSKLGLQCIGMHEK 130 G R+ + G L ++ + ++ S + L + ++ Sbjct: 30 GPLTRIDLLGVPALAVTGHTLARQLLTDTRLVKDINAWSLWQSGTVTRQWPLIGMIDVDR 89 Query: 131 GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 190 + + PE + R +AL+ L + + LD LE + VD+ ++ Sbjct: 90 SMFTVDGPEH-RRLRIKTTQALTRRRLDALKPTIERYVAELLDDLERAGADGAVVDLKSV 148 Query: 191 LRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKD 250 + L +R+ + + Q W FF I + + + + Sbjct: 149 F-------AYPLPMRVISALMGVPSEDQEQLLTWYK------AFFSILTPQDERLRVIDE 195 Query: 251 LKDAIEVLIAEKRRRISTEEKLEECMDFATELILA-EKRGDLTRENVNQCILEMLIAAPD 309 + ++ + E D + LI A + LT E V + ++ A + Sbjct: 196 MHGYFTEMV--------RRKTAEPGDDLTSALIYATDGETPLTEEEVIGNLQALVAAGHE 247 Query: 310 TMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRY-QP 368 T + + + HP + IG E I E++R+ P Sbjct: 248 TTVSLILTAVRALLSHPEQLRLVR---DGEIGW--------------ETAIEETLRWDGP 290 Query: 369 VVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL--EFFPKPNEFTLENFAKNVPYRY 426 V+ L+MR A ED + + +G ++++ + R ++F + Sbjct: 291 VIHLLMRFATEDIDLGDAVIPRGEGVVMSYRAIGRDITVHGADADDFDITR----ATAAR 346 Query: 427 FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF-------HVKTLQGQCVESIQKIHDLSL 479 FG GP C G +A + L L RF + + V + + + Sbjct: 347 HISFGHGPHICPGAALARLEAAIALPALFTRFPHLHPALPLDQIPNLPVLTQNDLSHFPI 406 Query: 480 H 480 H Sbjct: 407 H 407 >2Z36-A nrPDB Length = 413 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 64/410 (15%), Positives = 135/410 (32%), Gaps = 61/410 (14%) Query: 83 EFMRVWI-SGEETLIISKSSSMFHIMKHNHYSSR---------FGSKLGLQCIGMHEKGI 132 +V + SG + +S ++ +SS LQ + + Sbjct: 36 PINKVRLTSGGQAWWVSGHEEARAVLADGRFSSDKRKDGFPLFTLDAATLQQLRSQPPLM 95 Query: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLR 192 + + E R + + L + + + +D + + + VD++ L Sbjct: 96 LGMDGAEH-SAARRPVIGEFTVKRLAALRPRIQDIVDHFIDDM--LATDQRPVDLVQALS 152 Query: 193 RVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLK 252 + + + + +F + +++ + ++ +L+ Sbjct: 153 L-------PVPSLVICELLGVPYTDHDFFQSRTTMMVS-------RTSMEDRRRAFAELR 198 Query: 253 DAIEVLIAEKRRRISTEEKLEECMDFAT-ELILAEKRGDLTRENVNQCILEMLIAAPDTM 311 I+ LI T ++ E D + ++ + G L + +L A +T Sbjct: 199 AYIDDLI--------TRKESEPGDDLFSRQIARQRQEGTLDHAGLVSLAFLLLTAGHETT 250 Query: 312 SVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVD 371 + + + + HP + + E +RY + D Sbjct: 251 ANMISLGVVGLLSHPEQLTVVKANPGR-----------------TPMAVEELLRYFTIAD 293 Query: 372 LVM-RKALEDDVIDGYPVKKGTNIILNIGRMH-RLEFFPKPNEFTLENFAKNVPYRYFQP 429 V R A ED I G +K G +I+++ + F P +E A R+ Sbjct: 294 GVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVERGA-----RHHLA 348 Query: 430 FGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSL 479 FGFGP C G+ +A + ++ + TL RR L +E + D + Sbjct: 349 FGFGPHQCLGQNLARMELQIVFDTLFRRIPSLRLA-VPMEDVPFKGDSVI 397 >6B11-A nrPDB Length = 440 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 54/317 (17%), Positives = 117/317 (36%), Gaps = 39/317 (12%) Query: 149 MKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPL 208 AL G + L+ ++++ VT + ++ D + + ++ Sbjct: 138 HGALRGHFIPEFGLRRVRELRPSVEQI--VTGLLDDLTARGDEADLLADFALPMATQVIC 195 Query: 209 DESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRIST 268 I + + YF +P + +++ +L+D ++ LI+ K R S Sbjct: 196 RLLDIPYEDRDYFQERTEQATRPAAGEE-------ALEALLELRDYLDRLISGKTGRESG 248 Query: 269 EEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNV 328 + ++ + G L+ +V + +L A +T + + + ++ +HP Sbjct: 249 DG-------MLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMVTMSVLVLLQHPTA 301 Query: 329 EEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPV 388 + ++ + E +RY + D + R A D IDG+ + Sbjct: 302 WRELT-----------------VNPGLLPGAVDELLRYLSIADGLRRSATADIEIDGHTI 344 Query: 389 KKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMM 447 + G ++ + +R E F +P F + A R FG+GP C G+ +A + + Sbjct: 345 RAGDGLVFLLAAANRDEAVFSEPEAFDIHRSA-----RRHVAFGYGPHQCLGQNLARMEL 399 Query: 448 KAILVTLLRRFHVKTLQ 464 + L +L R Sbjct: 400 EVALGAVLERLPALRPT 416 >6A7J-A nrPDB Length = 411 Score = 165 bits (418), Expect = 4e-41, Method: Composition-based stats. Identities = 68/429 (15%), Positives = 139/429 (32%), Gaps = 70/429 (16%) Query: 82 GEFMRVWI-SGEETLIISKSSSMFHIM----KHNHYS-------SRFGSKLGLQCIGMHE 129 G V + G ++ ++ + + L + Sbjct: 26 GPLAEVELPGGVHVYAVTHHKEARALLTDSRVVKDINVWNAWQRGEIPADWPLIGLVNPG 85 Query: 130 KGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLT 189 + ++ + P+ + R +AL+ + ++ L+RL + VD+ Sbjct: 86 RSMLTVDGPDH-RRLRTLVAQALTVKRVEKLRAGIEALTNASLERLAALP-AGEPVDLKA 143 Query: 190 LLRR-VMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSV 248 + ++ + L D + + +F P + + L+ K Sbjct: 144 EFAYPLPMNVISELMGVDAADHPRLKELFEKFFSTQTPPEEVPQMMADLGTLFTK----- 198 Query: 249 KDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAA 307 I E+K D + LI A + GD LT E + + ++ A Sbjct: 199 -----------------IVEEKKANPGDDLTSALIAASEDGDHLTDEEILNTLQLIIAAG 241 Query: 308 PDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRY- 366 +T + ++ +A HP + ++ GE E I E++R+ Sbjct: 242 HETTISLIVNVVEALAIHPEQRKKVLS------GEIP-----------WEGVIEETLRWN 284 Query: 367 QPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE--FFPKPNEFTLENFAKNVPY 424 P +++R A ED + + KG ++++ G + R E + P +F Sbjct: 285 TPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDEEQYGPTAGDFDATRTPNR--- 341 Query: 425 RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF-------HVKTLQGQCVESIQKIHDL 477 FG GP C G ++ + L L RF L+ + + + +HDL Sbjct: 342 --HIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVPAAELRNKPIVTQNDLHDL 399 Query: 478 SLHPDETKN 486 + Sbjct: 400 PVKLGCPFG 408 >2VZM-A nrPDB Length = 436 Score = 164 bits (416), Expect = 5e-41, Method: Composition-based stats. Identities = 60/382 (15%), Positives = 129/382 (33%), Gaps = 52/382 (13%) Query: 82 GEFMRVWI-SGEETLIISKSSSMFHIMKHNHYSSRFGSKL-GLQCIGMHEKGIIFNNNPE 139 G RV G E ++ ++ +S + + L + ++P Sbjct: 59 GPAHRVRTPEGNEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPP 118 Query: 140 LWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTS 199 R + + + + E + +D + + G D++ L + Sbjct: 119 RHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPD--GRADLMESL-------A 169 Query: 200 NTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLI 259 L + + + + + F W + PD + + ++ ++ + LI Sbjct: 170 WPLPITVISELLGVPEPDRAAFRVWTDAFVFPDDP-------AQAQTAMAEMSGYLSRLI 222 Query: 260 AEKRRRISTEEKLEECMDFATELILA--EKRGDLTRENVNQCILEMLIAAPDTMSVSLFF 317 KR ++ D + L+ E LT E + +L+A +T + Sbjct: 223 DSKRG--------QDGEDLLSALVRTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIAN 274 Query: 318 MLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVM-RK 376 ++ + HP+ A+ + +++ + E +RY+ V+ R Sbjct: 275 GMYALLSHPDQLAAL-----------------RADMTLLDGAVEEMLRYEGPVESATYRF 317 Query: 377 ALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYFQPFGFGPR 435 +E +DG + G +++ + HR E FP P+ F + FG G Sbjct: 318 PVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRR-----DTAGHLAFGHGIH 372 Query: 436 GCAGKYIAMVMMKAILVTLLRR 457 C G +A + + + LL R Sbjct: 373 FCIGAPLARLEARIAVRALLER 394 >3ABB-A nrPDB Length = 408 Score = 164 bits (415), Expect = 7e-41, Method: Composition-based stats. Identities = 63/430 (14%), Positives = 137/430 (31%), Gaps = 67/430 (15%) Query: 75 NYYNRVYG--EFMRVWIS-GEETLIISKSSSMFHIMKHNHYSSRFGS-------KLGLQC 124 Y G +V + G +I+ + ++ SS +G + Sbjct: 28 KAYEERRGESPLTQVTLFDGRPAWLITGHAEGRALLVDPRLSSDWGHPDFPVVVRRTEDR 87 Query: 125 IGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGY 184 G+ I ++ R + + + + + LD + + Sbjct: 88 GGLAFPLIGVDDPVHA--RQRRMLIPSFGVKRMNAIRPRLQSLVDRLLDDMLAKGPGADL 145 Query: 185 VDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKY 244 V L + + + +F+ + + + Sbjct: 146 VSAFAL----------PVPSVAICELLGVPYGDHDFFEECSRNFVGAATSAEADAAFG-- 193 Query: 245 EKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAE-KRGDLTRENVNQCILEM 303 +L + L+ ++ E ELI + + GDL + V L + Sbjct: 194 -----ELYTYLHGLV--------GRKQAEPEDGLLDELIARQLEEGDLDHDEVVMIALVL 240 Query: 304 LIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYES 363 L+A +T ++ + +HP + ++++ V G + E Sbjct: 241 LVAGHETTVNAIALGALTLIQHPEQIDVLLRDPGAVSG-----------------VVEEL 283 Query: 364 MRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENFAKNV 422 +R+ V D ++R A ED + G +K G ++++I M+R + + P+ F A Sbjct: 284 LRFTSVSDHIVRMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDIFDARRNA--- 340 Query: 423 PYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPD 482 R+ FG G C G+ +A ++ L L R L ++ + Sbjct: 341 --RHHVGFGHGIHQCLGQNLARAELEIALGGLFARIPGLRLA-VPLDEVPIKAG-----H 392 Query: 483 ETKNMLEMIF 492 + + +E+ Sbjct: 393 DAQGPIELPV 402 >2Y5N-A nrPDB Length = 417 Score = 164 bits (415), Expect = 8e-41, Method: Composition-based stats. Identities = 54/383 (14%), Positives = 133/383 (34%), Gaps = 51/383 (13%) Query: 83 EFMRVWI-SGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGM-HEKGIIFNNNPEL 140 RV GEE ++++ + ++ + KG + + +P Sbjct: 51 PVSRVRPPYGEEAWLVTRYEDVRAVLGDGRFVRGPSMTRDEPRTRPEMVKGGLLSMDPPE 110 Query: 141 WKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSN 200 R +KA + + E +D++ + V + + Sbjct: 111 HSRLRRLVVKAFTARRAESLRPRAREIAHELVDQMAATGQPADLVAMF----------AR 160 Query: 201 TLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIA 260 L +R+ + + F W + ++ +++ + + LI Sbjct: 161 QLPVRVICELLGVPSADHDRFTRWSGAFLSTAEVTA-----EEMQEAAEQAYAYMGDLID 215 Query: 261 EKRRRISTEEKLEECMDFATELILA-EKRGDLTRENVNQCILEMLIAAPDTMSVSLFFML 319 +R+ E D + L+ A +++ L+ + + + +L+A ++ + + + Sbjct: 216 RRRK--------EPTDDLVSALVQARDQQDSLSEQELLDLAIGLLVAGYESTTTQIADFV 267 Query: 320 FLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLV--MRKA 377 +L+ P + + + + +++ + + E R+ P+ R A Sbjct: 268 YLLMTRPELRRQL-----------------LDRPELIPSAVEELTRWVPLGVGTAFPRYA 310 Query: 378 LEDDVIDGYPVKKGTNIILNIGRMHRLEF-FPKPNEFTLENFAKNVPYRYFQPFGFGPRG 436 +ED + G ++ G ++ + G +R + FP + ++ FG G Sbjct: 311 VEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDRT-----PNQHLGFGHGVHH 365 Query: 437 CAGKYIAMVMMKAILVTLLRRFH 459 C G +A V ++ L LL+R Sbjct: 366 CLGAPLARVELQVALEVLLQRLP 388 >2ZBZ-A nrPDB Length = 412 Score = 164 bits (415), Expect = 8e-41, Method: Composition-based stats. Identities = 71/423 (16%), Positives = 144/423 (34%), Gaps = 66/423 (15%) Query: 82 GEFMRVW-ISGEETLIISKSSSMFHIM-----KHNHYSSRFGSKLG-LQCIGMHEKGIIF 134 G RV G + +++K + ++ N F + + + + I Sbjct: 38 GPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSPAFEAVRESPQAFIG 97 Query: 135 NNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRV 194 + PE R + + + M E + LD + + D+++ Sbjct: 98 LDPPEHGTR-RRMTISEFTVKRIKGMRPEVEEVVHGFLDEMLAAGPTA---DLVSQFALP 153 Query: 195 MLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDA 254 + L +P + + DA + L+ D ++ + DL Sbjct: 154 VPSMVICRLLGVP------YADHEFFQDASKRLVQSTDAQSALT--------ARNDLAGY 199 Query: 255 IEVLIAEKRRRISTEEKLEECMDFATELILAE-KRGDLTRENVNQCILEMLIAAPDTMSV 313 ++ LI T+ + E L+ + G++ RE + + +LIA +T + Sbjct: 200 LDGLI--------TQFQTEPGAGLVGALVADQLANGEIDREELISTAMLLLIAGHETTAS 251 Query: 314 SLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLV 373 + + HP A+ ++ + E +RY + D+ Sbjct: 252 MTSLSVITLLDHPEQYAAL-----------------RADRSLVPGAVEELLRYLAIADIA 294 Query: 374 M-RKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENFAKNVPYRYFQPFG 431 R A D ++G ++ G +I+ +R + P+ + A R+ FG Sbjct: 295 GGRVATADIEVEGQLIRAGEGVIVVNSIANRDGTVYEDPDALDIHRSA-----RHHLAFG 349 Query: 432 FGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDET-KNMLEM 490 FG C G+ +A + ++ IL L+ R L + L L P T + + E+ Sbjct: 350 FGVHQCLGQNLARLELEVILNALMDRVPTLRLA-------VPVEQLVLRPGTTIQGVNEL 402 Query: 491 IFT 493 T Sbjct: 403 PVT 405 >4GGV-A nrPDB Length = 418 Score = 164 bits (414), Expect = 9e-41, Method: Composition-based stats. Identities = 61/385 (15%), Positives = 125/385 (32%), Gaps = 36/385 (9%) Query: 96 IISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGP 155 + +M + H+ ++S L + +G + +P + R +A + Sbjct: 58 VYGYPEAMDILNDHDTFTSDLAHLLPVSVDAPLLEGDMSQMDPPRHRKYRQLVSRAFTPR 117 Query: 156 GLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVV 215 + M T A+ + LD ++ + D + L + + + + Sbjct: 118 LVADMETRVADITRELLDAVDGKPEI-----------EIAADLAYPLPVIVIAELLGVPA 166 Query: 216 KIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEEC 275 + F W +I+ F + E+ V+D + + L+ + TE + Sbjct: 167 GDRDLFKKWADDIIEGFSGFSFLDTSGQGEQDVRDATERLRPLL-DYMAGHVTERRRTPR 225 Query: 276 MDFATELILAEKRGD-LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIK 334 D T L+ AE G+ LT + +L+ T +++L + + P V + Sbjct: 226 EDLLTHLVQAEVDGERLTDNEIVNVANILLVTGHITTTMTLGNTVLCLDADPEVAAKV-- 283 Query: 335 EIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNI 394 ++ I E++R + R + + G + K + Sbjct: 284 ---------------RADRSLVPGAIEEALRVLSPSAALARGTSREVEVAGTVIPKDQIV 328 Query: 395 ILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVT 453 +L +G +R F P + FG G C G +A + + L Sbjct: 329 MLWLGAGNRDPRQFTDPEVYDPTRDPNP-----HFGFGRGIHFCLGAPLARLEGRVALNA 383 Query: 454 LLRRFHVKTLQGQCVESIQKIHDLS 478 L RF V + D+ Sbjct: 384 LFDRFPVLRTDPAKPPTFFPTPDMI 408 >5XJN-A nrPDB Length = 455 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 55/320 (17%), Positives = 109/320 (34%), Gaps = 36/320 (11%) Query: 152 LSGPGLVRMVTVCAESLKTHLDR---LEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPL 208 ++ G + A H ++ Y + +R +++D + Sbjct: 124 MTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTPRRYKALEPDIRAMVIDRVEKMLANDQH 183 Query: 209 DESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVL-IAEKR---- 263 + LI DI ++ ++ D + I Sbjct: 184 VGDMVSDLAYDIPTITILTLIGADISMVDTYKRWSDSRAAMTWGDLSDEEQIPHAHNLVE 243 Query: 264 -----RRISTEEKLEECMDFATELILAEKRG-DLTRENVNQCILEMLIAAPDTMSVSLFF 317 +R+ + + +L+ A++ G ++T + + +L A +T + + Sbjct: 244 YWQECQRMVADAHAHGGDNLTADLVRAQQEGQEITDHEIASLLYSLLFAGHETTTTLISN 303 Query: 318 MLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKA 377 ++ HP +AI++ K++ + E +RY + RKA Sbjct: 304 CFRVLLDHPEQWQAILE-----------------NPKLIPAAVDEVLRYSGSIVGWRRKA 346 Query: 378 LEDDVIDGYPVKKGTNIILNIGRMHRLEF-FPKPNEFTLENFAKNVPYRYFQPFGFGPRG 436 L+D I G +K+G ++L +G +R E F EF + R FGFG Sbjct: 347 LKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEFDISR----ANAREHLSFGFGIHY 402 Query: 437 CAGKYIAMVMMKAILVTLLR 456 C G +A + K L + R Sbjct: 403 CLGNMLAKLQAKICLEEVTR 422 >5GWE-A nrPDB Length = 405 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 55/320 (17%), Positives = 109/320 (34%), Gaps = 36/320 (11%) Query: 152 LSGPGLVRMVTVCAESLKTHLDR---LEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPL 208 ++ G + A H ++ Y + +R +++D + Sbjct: 74 MTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTPRRYKALEPDIRAMVIDRVEKMLANDQH 133 Query: 209 DESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVL-IAEKR---- 263 + LI DI ++ ++ D + I Sbjct: 134 VGDMVSDLAYDIPTITILTLIGADISMVDTYKRWSDSRAAMTWGDLSDEEQIPHAHNLVE 193 Query: 264 -----RRISTEEKLEECMDFATELILAEKRG-DLTRENVNQCILEMLIAAPDTMSVSLFF 317 +R+ + + +L+ A++ G ++T + + +L A +T + + Sbjct: 194 YWQECQRMVADAHAHGGDNLTADLVRAQQEGQEITDHEIASLLYSLLFAGHETTTTLISN 253 Query: 318 MLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKA 377 ++ HP +AI++ K++ + E +RY + RKA Sbjct: 254 CFRVLLDHPEQWQAILE-----------------NPKLIPAAVDEVLRYSGSIVGWRRKA 296 Query: 378 LEDDVIDGYPVKKGTNIILNIGRMHRLEF-FPKPNEFTLENFAKNVPYRYFQPFGFGPRG 436 L+D I G +K+G ++L +G +R E F EF + R FGFG Sbjct: 297 LKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEFDISR----ANAREHLSFGFGIHY 352 Query: 437 CAGKYIAMVMMKAILVTLLR 456 C G +A + K L + R Sbjct: 353 CLGNMLAKLQAKICLEEVTR 372 >5XNT-A nrPDB Length = 411 Score = 163 bits (413), Expect = 1e-40, Method: Composition-based stats. Identities = 63/342 (18%), Positives = 129/342 (37%), Gaps = 43/342 (12%) Query: 132 IIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLL 191 I + PE K R A + L E ++ + +E +D++ L Sbjct: 88 ITEADPPEHRKR-RSLLAAAFTPRSLQNWEPRIQEIADELIEEM----DEETEIDIVQSL 142 Query: 192 RRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDL 251 ++ L + + D + K + F W +L P K+ ++ V +L Sbjct: 143 -------ASPLPIIVMSDLMGVPSKDRLLFKKWVDILFLP--------FDKEKQEEVNEL 187 Query: 252 KDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDL-TRENVNQCILEMLIAAPDT 310 K + I +++L D ++L+ AE G++ T + V + + +L A +T Sbjct: 188 KQVAAKEYYQYLYPIVVQKRLNPADDIISDLLKAEVDGEMFTDDEVVRTTMLILGAGVET 247 Query: 311 MSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVV 370 S L + + ++ + +E+ L ++ + E +RY+ + Sbjct: 248 TSHLLANSFYSLLYD---DKEVYQELHE-------------NLDLVPQAVEEMLRYRFNL 291 Query: 371 DLVMRKALEDDVIDGYPVKKGTNIILNIGRMH-RLEFFPKPNEFTLENFAKNVPYRYFQP 429 + R ED+ + G +K+G N+++ + + E F + Sbjct: 292 IKLDRTVKEDNDLLGVELKEGENVVVWMSAANLDEEMFEDAFTLNIHRPNNKK----HLT 347 Query: 430 FGFGPRGCAGKYIAMVMMKAILVTLLRRFH-VKTLQGQCVES 470 FG GP C G +A + K L T L++F ++ + +E Sbjct: 348 FGNGPHFCLGAPLARLEAKIALTTFLKKFKHIEAVPSFQLED 389 >1LG9-A nrPDB Length = 398 Score = 163 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 68/405 (16%), Positives = 141/405 (34%), Gaps = 66/405 (16%) Query: 82 GEFMRVWISG----EETLIISKSSSMFHIM-KHNHYSSRFGSKLGLQCIGMHEKGII--- 133 G RV I E + + + + +M H +S+R + + KGI Sbjct: 26 GALTRVTIGSGADAETHWMATAHAVVRQVMGDHQQFSTR---RRWDPRDEIGGKGIFRPR 82 Query: 134 ------FNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDV 187 + +P R + + RM + + LD +E + + D+ Sbjct: 83 ELVGNLMDYDPPEHTRLRRKLTPGFTLRKMQRMAPYIEQIVNDRLDEMERAGSPA---DL 139 Query: 188 LTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKS 247 + + + + +P D+ + +K+ + L +K + Sbjct: 140 IAFVADKVPGAVLCELVGVPRDDRDMFMKLCHG--------------HLDASLSQKRRAA 185 Query: 248 V-KDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIA 306 + + +IA +R+ ++AE D T E + +++++A Sbjct: 186 LGDKFSRYLLAMIARERKEPGEG---------MIGAVVAEYGDDATDEELRGFCVQVMLA 236 Query: 307 APDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRY 366 D +S + + + +HP +A + Q+ + + E +RY Sbjct: 237 GDDNISGMIGLGVLAMLRHPEQIDAFRGDEQSA-----------------QRAVDELIRY 279 Query: 367 QPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYR 425 V R A ED + G +KKG ++I ++ +R P+ L+ + +P Sbjct: 280 LTVPYSPTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPAL-APDVDRLDVTREPIP-- 336 Query: 426 YFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVES 470 FG G C G +A + ++ + L RRF L ++ Sbjct: 337 -HVAFGHGVHHCLGAALARLELRTVFTELWRRFPALRLADPAQDT 380 >3P3Z-A nrPDB Length = 416 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 56/327 (17%), Positives = 115/327 (35%), Gaps = 43/327 (13%) Query: 142 KTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNT 201 + R + + + +++ +D+L G D + + Sbjct: 109 RRLRGLATHPFTPRRITAVQPFVRSTVEQLIDKL-----PQGDFDFVQHFPHPLPALVMC 163 Query: 202 LFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAE 261 L PL++ V ++ + AL DI K E+ + + D + I + Sbjct: 164 QLLGFPLEDYDTVGRLSIETNLGLALSNDQDILV-------KVEQGLGRMFDYLVAAIEK 216 Query: 262 KRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFL 321 + K+E D ++++ A G L + + +L+A +T + L ++ Sbjct: 217 R--------KVEPGDDLTSDIVRAFHDGVLDDYELRTLVATVLVAGYETTNHQLALAMYD 268 Query: 322 IAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLV-MRKALED 380 A+HP+ I + ++ + E +R+ P + + R A ED Sbjct: 269 FAQHPDQWMKIKE-----------------NPELAPQAVEEVLRWSPTLPVTATRVAAED 311 Query: 381 DVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAG 439 ++G + GT + + HR F + F + + P FG GP C G Sbjct: 312 FEVNGVRIPTGTPVFMCAHVAHRDPRVFADADRFDITV-KREAPS---IAFGGGPHFCLG 367 Query: 440 KYIAMVMMKAILVTLLRRFHVKTLQGQ 466 +A + + + L R + G+ Sbjct: 368 TALARLELTEAVAALATRLDPPQIAGE 394 >3NC3-A nrPDB Length = 441 Score = 161 bits (408), Expect = 5e-40, Method: Composition-based stats. Identities = 57/323 (17%), Positives = 119/323 (36%), Gaps = 44/323 (13%) Query: 145 RPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFL 204 R +++ G L + + ++ + L E G D++ + T + Sbjct: 125 RRIVVRSFIGDALDHLSPLIKQNAENLL----APYLERGKSDLVNDFGK-------TFAV 173 Query: 205 RIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKD-LKDAIEVLIAEKR 263 + +D + + W + + S + + + L + +I E+R Sbjct: 174 CVTMDMLGLDKRDHEKISEWHSGVADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERR 233 Query: 264 RRISTEEKLEECMDFATELILAEKRG-DLTRENVNQCILEMLIAAPDTMSVSLFFMLFLI 322 + D + L +E G L+ +++ IL +L+AA + +L M++ + Sbjct: 234 --------VNPGSDLISILCTSEYEGMALSDKDILALILNVLLAATEPADKTLALMIYHL 285 Query: 323 AKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDV 382 +P D + ++ I E++RY+P V L+ R+ +D V Sbjct: 286 LNNPEQMN-----------------DVLADRSLVPRAIAETLRYKPPVQLIPRQLSQDTV 328 Query: 383 IDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRY-----FQPFGFGPRG 436 + G +KK T + IG +R E F +P+ F + + + FG G Sbjct: 329 VGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIKSAFSGAARHLAFGSGIHN 388 Query: 437 CAGKYIAMVMMKAILVTLLRRFH 459 C G A ++ + +L + Sbjct: 389 CVGTAFAKNEIEIVANIVLDKMR 411 >3WVS-A nrPDB Length = 401 Score = 161 bits (407), Expect = 6e-40, Method: Composition-based stats. Identities = 57/383 (14%), Positives = 125/383 (32%), Gaps = 53/383 (13%) Query: 91 GEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQ---CIGMHEKGIIFNNNPELWKTTRPF 147 GE + ++ ++ +S + K + + P+ R Sbjct: 46 GEPAWLATRYEDARLVLGDARFSRALSEEHDPPRARKFNAQAKSMFNMDAPDH-TRLRRL 104 Query: 148 FMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIP 207 KA + + + + +D + + V D + + + Sbjct: 105 ISKAFTIRRVEELRPKVHDLAHRLIDDMLAKGEPADLVA----------DYALPIPTTVI 154 Query: 208 LDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRIS 267 + + + + F W ++ K+ +L I +IA +R Sbjct: 155 CELLGVPFEDREKFGRWTDAILSTSTLNPEEGRVKR-----MELVGYIGGIIAARRA--- 206 Query: 268 TEEKLEECMDFATELILAEK-RGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHP 326 + D + +I A + LT + + + +LIA +T + + ++ + P Sbjct: 207 -----QPADDLISGMIEARDVQDKLTEQELLDHCIGLLIAGHETTASQIPSFVYALLDQP 261 Query: 327 NVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDL--VMRKALEDDVID 384 + + + +++ + + E R+ P+ R A ED + Sbjct: 262 QHWKRL-----------------LDDPELIPSAVEELFRFVPLGSGSAAPRYAREDIEVG 304 Query: 385 GYPVKKGTNIILNIGRMHRLEF-FPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIA 443 G V+ G +++ +G +R F P E L+ P + FG G C G +A Sbjct: 305 GTLVRAGEPVLVALGAANRDGLRFEDPEEIKLDR-----PSNHHIGFGHGIHHCLGAPLA 359 Query: 444 MVMMKAILVTLLRRFHVKTLQGQ 466 + ++ L LL R + G Sbjct: 360 RLELQEALRALLERLPTLKVAGD 382 >6A7I-A nrPDB Length = 411 Score = 160 bits (405), Expect = 1e-39, Method: Composition-based stats. Identities = 67/416 (16%), Positives = 137/416 (32%), Gaps = 59/416 (14%) Query: 84 FMRVWISGEETLIISKSSSMFHIMKHNHYS-SRFGSKLGLQCIGMHEKGIIFNNNPELWK 142 V E +++ S + I N + L + + ++ + + + Sbjct: 39 VYAVTRHAEARALLTDSRVVKDIDVWNAWRRGEIPMDWPLIGLANPGRSMLTVDGADH-R 97 Query: 143 TTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRR-VMLDTSNT 201 R +AL+ + R+ L++L + VD+ + ++ + Sbjct: 98 RLRTLVAQALTVKRVERLRAGIEALTNASLEKLAALP-AGEPVDLKAEFAYPLPMNVISE 156 Query: 202 LFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAE 261 L D + + +F P + + L+ K I + Sbjct: 157 LMGVDAADHPRLKELFEKFFSTQTPPEEVPQMMADLGALFTK---------------IVD 201 Query: 262 KRRRISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAAPDTMSVSLFFMLF 320 +R D + LI A + GD LT E + + ++ A +T + ++ Sbjct: 202 AKRT-------NPGDDLTSALIAASENGDHLTDEEIVNTLQLIIAAGHETTISLIVNVVE 254 Query: 321 LIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRY-QPVVDLVMRKALE 379 + HP + + + IG + I E++R+ P +++R A E Sbjct: 255 ALQTHPEQRKKV---LNGEIGW--------------DGVIEETLRWNTPTSHVLIRFATE 297 Query: 380 DDVIDGYPVKKGTNIILNIGRMHRLE--FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGC 437 D + + KG +I++ G + R E + P EF FG GP C Sbjct: 298 DIEVGDKILPKGEGLIISFGALGRDEEQYGPTAGEFDATRTPNR-----HIAFGHGPHVC 352 Query: 438 AGKYIAMVMMKAILVTLLRRF-------HVKTLQGQCVESIQKIHDLSLHPDETKN 486 G ++ + L L RF L+ + + + +H+L + Sbjct: 353 PGAALSRLEAGIALPALYERFPELDLAVPASDLRNKPIVTQNDLHELPVKLGCPFG 408 >5IT1-A nrPDB Length = 399 Score = 160 bits (404), Expect = 1e-39, Method: Composition-based stats. Identities = 67/399 (16%), Positives = 135/399 (33%), Gaps = 55/399 (13%) Query: 88 WISGEETLIISKSSSMFHIMKHNHYSSRFG----SKLGLQCIGMHEKGIIFNNNPELWKT 143 + SG E +++ + +++ +S ++ G+ +++ + PE Sbjct: 39 FTSGHEAWLVTGYEQVRAVLRDPSFSVGVPHALHTQDGVVTQKPGRGSLLWQDAPEH-TD 97 Query: 144 TRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLF 203 R K + + + + HLD +E V +N + Sbjct: 98 DRKLLAKEFTVRRMQALRPNIQRIVDEHLDAIEARGGPVDLVKTF----------ANPVP 147 Query: 204 LRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKR 263 + D + + + F +++ D + E + L + L+ E+R Sbjct: 148 SMVISDLFGVPAERRAEFQEIAEAMMRVDQDAAAT------EAAGMRLGGLLYQLVQERR 201 Query: 264 RRISTEEKLEECMDFATELILAEK-RGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLI 322 D + LI E G + + +LIAA DT + + L+ Sbjct: 202 A--------NPGDDLISALITTEDPDGVIDDMFLMNAAGTLLIAAHDTTACMIGLGTALL 253 Query: 323 AKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDL-VMRKALEDD 381 P+ + K+ ++ N + E +RY + R A +D Sbjct: 254 LDRPDQLALLQKD-----------------PSLIGNAVEELLRYLTIGQFGAERVATQDG 296 Query: 382 VIDGYPVKKGTNIILNIGRMH-RLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGK 440 I G + KG ++ ++ F P F + FGFG C G+ Sbjct: 297 EIGGVRIAKGEQVVTHLLSADFDPAFVEDPERFDITRRPAP-----HLAFGFGAHQCIGQ 351 Query: 441 YIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSL 479 +A + ++ + TL RRF L + VE ++ +D+ Sbjct: 352 QLARIELQIVFGTLFRRFPTLRLA-KPVEELRFRNDMVF 389 >4YT3-A nrPDB Length = 410 Score = 159 bits (402), Expect = 2e-39, Method: Composition-based stats. Identities = 56/330 (16%), Positives = 122/330 (36%), Gaps = 42/330 (12%) Query: 132 IIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLL 191 I ++ P+ K R A + L E + ++ + +D++ L Sbjct: 88 ITESDPPDHRKR-RSLLAAAFTPRSLQNWEPRIQEIADELIGQM----DGGTEIDIVASL 142 Query: 192 RRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDL 251 ++ L + + D + K + F W L P ++ ++ V L Sbjct: 143 -------ASPLPIIVMADLMGVPSKDRLLFKKWVDTLFLP--------FDREKQEEVDKL 187 Query: 252 KDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDL-TRENVNQCILEMLIAAPDT 310 K + I +++L D ++L+ +E G++ T + V + + +L A +T Sbjct: 188 KQVAAKEYYQYLYPIVVQKRLNPADDIISDLLKSEVDGEMFTDDEVVRTTMLILGAGVET 247 Query: 311 MSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVV 370 S L + + ++ + +E+ L ++ + E +R++ + Sbjct: 248 TSHLLANSFYSLLYD---DKEVYQELHE-------------NLDLVPQAVEEMLRFRFNL 291 Query: 371 DLVMRKALEDDVIDGYPVKKGTNIILNIGRMH-RLEFFPKPNEFTLENFAKNVPYRYFQP 429 + R ED+ + G +K+G ++++ + + E F P + Sbjct: 292 IKLDRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFTLNIHRPNNKK----HLT 347 Query: 430 FGFGPRGCAGKYIAMVMMKAILVTLLRRFH 459 FG GP C G +A + K L L++F Sbjct: 348 FGNGPHFCLGAPLARLEAKIALTAFLKKFK 377 >1GWI-A nrPDB Length = 411 Score = 159 bits (402), Expect = 3e-39, Method: Composition-based stats. Identities = 66/422 (15%), Positives = 131/422 (31%), Gaps = 69/422 (16%) Query: 82 GEFMRVWI-SGEETLIISKSSSMFHIM----KHNHYS-------SRFGSKLGLQCIGMHE 129 G V + G ++ + ++ + + L + Sbjct: 30 GPLAAVELPGGVPVWAVTHHAEAKALLTDPRLVKDINVWGAWRRGEIPADWPLIGLANPG 89 Query: 130 KGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLT 189 + ++ + E + R +AL+ + M E LD L Sbjct: 90 RSMLTVDGAEH-RRLRTLVAQALTVRRVEHMRGRITELTDRLLDELPADGGVVDLKAAF- 147 Query: 190 LLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVK 249 + L + + D I + + L K FF ++ ++ Sbjct: 148 ---------AYPLPMYVVADLMGI---EEARLPRLKVLFEK---FFSTQTPPEEVVATLT 192 Query: 250 DLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAAP 308 +L + +A KR D + LI A + GD LT + + M+ A Sbjct: 193 ELASIMTDTVAAKRAA--------PGDDLTSALIQASENGDHLTDAEIVSTLQLMVAAGH 244 Query: 309 DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQ- 367 +T + + ++ HP ++ + E++R+ Sbjct: 245 ETTISLIVNAVVNLSTHPEQRALVLSGEAE-----------------WSAVVEETLRFST 287 Query: 368 PVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE--FFPKPNEFTLENFAKNVPYR 425 P +++R A ED + + G +I++ G + R E P + F L + N Sbjct: 288 PTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTADRFDLTRTSGN---- 343 Query: 426 YFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF-------HVKTLQGQCVESIQKIHDLS 478 FG GP C G ++ + L L RF L+ + V + + +L Sbjct: 344 RHISFGHGPHVCPGAALSRMEAGVALPALYARFPHLDLAVPAAELRNKPVVTQNDLFELP 403 Query: 479 LH 480 + Sbjct: 404 VR 405 >4Z5P-A nrPDB Length = 400 Score = 158 bits (400), Expect = 4e-39, Method: Composition-based stats. Identities = 55/342 (16%), Positives = 119/342 (34%), Gaps = 49/342 (14%) Query: 127 MHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVD 186 I + +P R KA + + M + E LD +E + + Sbjct: 80 ARRSDTILSLDPPEHTRLRRLLSKAFTARRMGAMQSWLEELFAGLLDGVERTGHPA---- 135 Query: 187 VLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEK 246 ++ D + + + + + +G F W +++ + K ++ Sbjct: 136 ------DIVRDLAQPFTIAVICRLLGVPYEDRGRFQHWSEVIMSTTAYSK-----EEAVS 184 Query: 247 SVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLI 305 + ++ + L++ +R D L+ A D LT + + + +L+ Sbjct: 185 ADASIRAYLADLVSARRAAPHD--------DLLGVLVSARDDDDRLTEDELITFGVTLLV 236 Query: 306 AAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMR 365 A +T + L M++ + H + + + + +++ + E +R Sbjct: 237 AGHETSAHQLGNMVYALLTHEDQLSLLRE-----------------QPELLPRAVEELLR 279 Query: 366 YQPVVDLVM--RKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNV 422 + P+ + V R ALED + G V+ G ++ +R F P+ + Sbjct: 280 FVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLDITREKNP- 338 Query: 423 PYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQ 464 FG G C G +A + ++ + LL RF L Sbjct: 339 ----HLAFGHGAHYCLGAQLARMELRVAIGGLLERFPGLRLA 376 >1Z8P-A nrPDB Length = 404 Score = 158 bits (399), Expect = 6e-39, Method: Composition-based stats. Identities = 66/414 (15%), Positives = 140/414 (33%), Gaps = 64/414 (15%) Query: 83 EFMRVWISGEETLIISKSSSMFHIMK--------HNHYSS---RFGSKLGLQCI--GMHE 129 V G++ +++ + Y F + LG Sbjct: 28 PVTPVRFLGQDAWLVTGYDEAKAALSDLRLSSDPKKKYPGVEVEFPAYLGFPEDVRNYFA 87 Query: 130 KGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLT 189 + ++ P R + + + M + LD + +SG VD++ Sbjct: 88 TNMGTSDPPTH-TRLRKLVSQEFTVRRVEAMRPRVEQITAELLDEV----GDSGVVDIVD 142 Query: 190 LLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVK 249 L +++ + + K +G F W + +I ++ ++ + Sbjct: 143 RFAH-------PLPIKVICELLGVDEKYRGEFGRWSS-----EILVMDPERAEQRGQAAR 190 Query: 250 DLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD--LTRENVNQCILEMLIAA 307 ++ + I L+ +R E D + LI + D L+ + + L +L+A Sbjct: 191 EVVNFILDLVERRR--------TEPGDDLLSALIRVQDDDDGRLSADELTSIALVLLLAG 242 Query: 308 PDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQ 367 ++ + +L+ HP+ + ++ + N + E +RY Sbjct: 243 FESSVSLIGIGTYLLLTHPDQLALVRRDPSA-----------------LPNAVEEILRYI 285 Query: 368 PVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRY 426 + R A E+ I G + + + +++ G +R + FP P+ F + R Sbjct: 286 APPETTTRFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFPDPHRFDVTR-----DTRG 340 Query: 427 FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480 FG G C G+ +A + + L L RF +L G + + L L Sbjct: 341 HLSFGQGIHFCMGRPLAKLEGEVALRALFGRFPALSL-GIDADDVVWRRSLLLR 393 >2WIO-A nrPDB Length = 431 Score = 158 bits (399), Expect = 6e-39, Method: Composition-based stats. Identities = 53/331 (16%), Positives = 110/331 (33%), Gaps = 44/331 (13%) Query: 131 GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 190 G+I +P + R A + + + + ++ L + D++ + Sbjct: 105 GMIHEIDPPEHRALRKVVSSAFTPRTISDLEPRIRDVTRSLL------ADAGESFDLVDV 158 Query: 191 LRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFK-ISWLYKKYEKSVK 249 L + L + I + + F W L+ + L ++ + Sbjct: 159 L-------AFPLPVTIVAELLGLPPMDHEQFGDWSGALVDIQMDDPTDPALAERIADVLN 211 Query: 250 DLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRG-DLTRENVNQCILEMLIAAP 308 L ++ AE+R + D + L+LAE G L E +L+A Sbjct: 212 PLTAYLKARCAERRA--------DPGDDLISRLVLAEVDGRALDDEEAANFSTALLLAGH 263 Query: 309 DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQP 368 T +V L ++ + +HP +A ++ + + E +RY+P Sbjct: 264 ITTTVLLGNIVRTLDEHPAHWDAAAEDPGR-----------------IPAIVEEVLRYRP 306 Query: 369 VVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENFAKNVPYRYF 427 + R + + G P+ + + +R + P+ F + Sbjct: 307 PFPQMQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSRKSGGAAQ--- 363 Query: 428 QPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 FG G C G +A + + L ++ RF Sbjct: 364 LSFGHGVHFCLGAPLARLENRVALEEIIARF 394 >6GMF-A nrPDB Length = 397 Score = 158 bits (398), Expect = 7e-39, Method: Composition-based stats. Identities = 58/373 (15%), Positives = 127/373 (34%), Gaps = 55/373 (14%) Query: 95 LIISKSSSMFHIMKHNHYSSRFGSK-------LGLQCIGMHEKGIIFNNNPELWKTTRPF 147 + + + + ++ H + F ++ G++ I+ + P K R Sbjct: 38 MAVGRYQDVARVL---HDAKGFSNRGWAASLPRGVKWDTSMPPSIVQVDPPRHGK-LRTL 93 Query: 148 FMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIP 207 KA + + ++ + +D L +S + + + + + + Sbjct: 94 VTKAFTPRTVAQLEPRIRDIAHELVDGL---RGKSTFEATVE--------VTVPMPMIVI 142 Query: 208 LDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRIS 267 + + + + F W ++ ++ + E+S ++ ++ Sbjct: 143 AEMLGVAPERRADFKRWSDDMVGSLALVRVGN-AAQLERSTQEFYAYFSEVLE------- 194 Query: 268 TEEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHP 326 E + E D ++L+ AE G+ LT V +LIA +T + + L + HP Sbjct: 195 -ERRREPREDLISQLLAAEVDGEKLTAGEVLSFANTLLIAGNETTTSLIGNALVALTDHP 253 Query: 327 NVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGY 386 A L ++ + E +RY+ + R+ + D I Sbjct: 254 EQLAAAQ-----------------ADLSLVPAVVEEVLRYESPAQCIFRQTMTDVEIGDE 296 Query: 387 PVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMV 445 + + ++ + +R E FP P+ F + K FG C G +A + Sbjct: 297 RIPARSVVLPLLASANRDESRFPDPDRFDIHRDTKG-----HLAFGLDIHFCIGAPLARL 351 Query: 446 MMKAILVTLLRRF 458 K +L LL R Sbjct: 352 EAKVMLEVLLARL 364 >1CPT-A nrPDB Length = 428 Score = 158 bits (398), Expect = 8e-39, Method: Composition-based stats. Identities = 56/336 (16%), Positives = 116/336 (34%), Gaps = 39/336 (11%) Query: 137 NPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVML 196 +P R + + ++ + + RL + E ++ L + + Sbjct: 106 DPPTHTAYRGLTLNWFQPASIRKLEENIRRIAQASVQRLLDFDGECDFMTDCALYYPLHV 165 Query: 197 DTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKIS--WLYKKYEKSVKDLKDA 254 + L +P D+ +++K+ F + + S +++ +++ D Sbjct: 166 VMTA---LGVPEDDEPLMLKLTQDFFGVHEPDEQAVAAPRQSADEAARRFHETIATFYDY 222 Query: 255 IEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD--LTRENVNQCILEMLIAAPDTMS 312 ++R D L+ K + + +N + + A DT S Sbjct: 223 FNGFTVDRR---------SCPKDDVMSLLANSKLDGNYIDDKYINAYYVAIATAGHDTTS 273 Query: 313 VSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDL 372 S + ++++P ++ + E++R+ V Sbjct: 274 SSSGGAIIGLSRNPEQLALA-----------------KSDPALIPRLVDEAVRWTAPVKS 316 Query: 373 VMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQPFG 431 MR AL D + G +K+G I+L+ +R E F P+EF + F FG Sbjct: 317 FMRTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEFDITRFPNR-----HLGFG 371 Query: 432 FGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQC 467 +G C G+++A + MK LL + L G Sbjct: 372 WGAHMCLGQHLAKLEMKIFFEELLPKLKSVELSGPP 407 >4TX3-A nrPDB Length = 404 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 59/391 (15%), Positives = 135/391 (34%), Gaps = 56/391 (14%) Query: 90 SGEETLIISKSSSMFHIM-KHNHYSSR--FGSKLGLQCIGMHEK----GIIFNNNPELWK 142 E T + + + + ++ H +S+R F + + G+ G + + +P Sbjct: 44 DAETTWLAAGHAVVRQVLGDHKRFSTRRRFDRRDEIGGTGVFRPRELVGNLMDYDPPEHT 103 Query: 143 TTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTL 202 R + + R+ E + LD +E+ + D++ L + Sbjct: 104 RLRHLLTPGFTQRRMRRLAPRIEEIVTDRLDAMEQAGPPA---DLIELFADEVPGAVLCE 160 Query: 203 FLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEK 262 + +P D+ A+ +++ S +K + + + ++A + Sbjct: 161 LIGVPRDDQAMFLQLCHR-------------HLDASLSARKRAAAGEAFARYLVAMMARE 207 Query: 263 RRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLI 322 R+ + D I+AE +T E + +++++A D +S + + + Sbjct: 208 RK---------DPGDGFIGSIVAEHGDTITDEELRGVCVQLMLAGDDNVSGMIGLGVLAL 258 Query: 323 AKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQP-VVDLVMRKALEDD 381 +HP A+ + Q+ + + E +RY R A+ED Sbjct: 259 LRHPEQIAALRGDDQSA-----------------DRAVDELIRYLTVPYAPTPRTAVEDV 301 Query: 382 VIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGK 440 ++ +K+G ++ ++ +R P + + FG G C G Sbjct: 302 MVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTRTPVP-----HVAFGHGIHHCLGA 356 Query: 441 YIAMVMMKAILVTLLRRFHVKTLQGQCVESI 471 + + ++ L RRF L E + Sbjct: 357 ALTRLQLRIAYTALWRRFPALQLADPAQEIM 387 >4TRI-A nrPDB Length = 407 Score = 156 bits (395), Expect = 2e-38, Method: Composition-based stats. Identities = 65/384 (16%), Positives = 132/384 (34%), Gaps = 55/384 (14%) Query: 116 FGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRL 175 F S G++ +I ++P+ R + ++ V +S+ D L Sbjct: 62 FSSTGGIRPDQPGMPYMIDMDDPQHLLR-RKLVNAGFTRKRVMDKV----DSIGRLCDTL 116 Query: 176 EEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFF 235 + E G D + D + L + + D ++ + W L+ Sbjct: 117 IDAVCERGECD-------FVRDIAAPLPMAVIGDMLGVLPTERDMLLKWSDDLVCGLSSH 169 Query: 236 KISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD-LTRE 294 +K + + + +I ++R E D + L+ +E G ++ + Sbjct: 170 VDEAAIQKLMDTFAAYTEFTKDVITKRRA--------EPTDDLFSVLVNSEVEGQRMSDD 221 Query: 295 NVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLK 354 + L +LI +T +L + +H + +A++ ++ Sbjct: 222 EIVFETLLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADVD----------------- 264 Query: 355 VMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEF 413 ++ I E +R+ V + R D V G ++ G I+L + E F P+ F Sbjct: 265 LLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRAGEKIMLMFESANFDESVFGDPDNF 324 Query: 414 TLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQK 473 ++ FGFG C G +A + ++ + +LRR L Sbjct: 325 RIDR-----NPNSHVAFGFGTHFCLGNQLARLELRLMTERVLRRLPDLRLADDA------ 373 Query: 474 IHDLSLHPDETKNMLE---MIFTP 494 + L P + E ++FTP Sbjct: 374 --PVPLRPANFVSGPESMPVVFTP 395 >3ABA-A nrPDB Length = 403 Score = 156 bits (395), Expect = 2e-38, Method: Composition-based stats. Identities = 65/399 (16%), Positives = 136/399 (34%), Gaps = 55/399 (13%) Query: 88 WISGEETLIISKSSSMFHIMKHNHYSSRFG----SKLGLQCIGMHEKGIIFNNNPELWKT 143 + SG E +++ + +++ + +S + ++ G+ +++ + PE Sbjct: 39 FTSGHEAWLVTGYEEVRALLRDSSFSVQVPHALHTQDGVVTQKPGRGSLLWQDEPEHTSD 98 Query: 144 TRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLF 203 R K + + + + HLD +E V +N + Sbjct: 99 -RKLLAKEFTVRRMQALRPNIQRIVDEHLDAIEARGGPVDLVKTF----------ANAVP 147 Query: 204 LRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKR 263 + D + V+ + F +++ D + E + L + L+ E+R Sbjct: 148 SMVISDLFGVPVERRAEFQDIAEAMMRVDQDAAAT------EAAGMRLGGLLYQLVQERR 201 Query: 264 RRISTEEKLEECMDFATELILAEKRGDLTRENVNQCIL-EMLIAAPDTMSVSLFFMLFLI 322 D + LI E + + +LIAA DT + + L+ Sbjct: 202 A--------NPGDDLISALITTEDPDGVVDDMFLMNAAGTLLIAAHDTTACMIGLGTALL 253 Query: 323 AKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVM-RKALEDD 381 P+ + ++ ++ N + E +RY + R A D Sbjct: 254 LDSPDQLALLRED-----------------PSLVGNAVEELLRYLTIGQFGGERVATRDV 296 Query: 382 VIDGYPVKKGTNIILN-IGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGK 440 + G + KG ++ + + F +P F + FGFG C G+ Sbjct: 297 ELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITRRPAP-----HLAFGFGAHQCIGQ 351 Query: 441 YIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSL 479 +A + ++ + TL RR L + VE ++ HD+ Sbjct: 352 QLARIELQIVFETLFRRLPGLRLA-KPVEELRFRHDMVF 389 >2XKR-A nrPDB Length = 398 Score = 155 bits (392), Expect = 3e-38, Method: Composition-based stats. Identities = 66/440 (15%), Positives = 140/440 (31%), Gaps = 58/440 (13%) Query: 70 IGSACNYYNRVYGEFMRVWISGEETLI-----ISKSSSMFHIMKHNHYSSRFGSKLGLQC 124 + N+Y W+ + + ++ +S+ ++ F + G++ Sbjct: 8 DLADGNFYASREARAAYRWMRANQPVFRDRNGLAAASTYQAVIDAERQPELFSNAGGIRP 67 Query: 125 IGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGY 184 +I ++P R + + V S+ D L + E G Sbjct: 68 DQPALPMMIDMDDPAHLLR-RKLVNAGFTR----KRVKDKEASIAALCDTLIDAVCERGE 122 Query: 185 VDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKY 244 D + D + L + + D + + + F W L+ ++ Sbjct: 123 CD-------FVRDLAAPLPMAVIGDMLGVRPEQRDMFLRWSDDLVTFLSSHVSQEDFQIT 175 Query: 245 EKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEM 303 + D IA +R + D + L+ +E G+ L+ + + L + Sbjct: 176 MDAFAAYNDFTRATIAARRA--------DPTDDLVSVLVSSEVDGERLSDDELVMETLLI 227 Query: 304 LIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYES 363 LI +T +L + ++ + + + + ++ I E Sbjct: 228 LIGGDETTRHTLSGGTEQLLRNRDQWDLLQ-----------------RDPSLLPGAIEEM 270 Query: 364 MRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNV 422 +R+ V + R D G + G ++L + E F +P +F ++ Sbjct: 271 LRWTAPVKNMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQR----- 325 Query: 423 PYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF-HVKTLQGQCVESIQKIHDLSLHP 481 FGFG C G +A + + + +LRR ++ + V L L P Sbjct: 326 NPNSHLAFGFGTHFCLGNQLARLELSLMTERVLRRLPDLRLVADDSV--------LPLRP 377 Query: 482 DETKNMLEMIFTPRNSDRCL 501 + LE + L Sbjct: 378 ANFVSGLESMPVVFTPSPPL 397 >3RWL-A nrPDB Length = 426 Score = 154 bits (389), Expect = 9e-38, Method: Composition-based stats. Identities = 49/340 (14%), Positives = 113/340 (33%), Gaps = 49/340 (14%) Query: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRL----EEVTNESGYVDVL 188 + R ++ L + E + LD L E + +++ Sbjct: 111 FIAMDRPRHDEQRKAVSPIVAPANLAALEGTIRERVSKTLDGLPVGEEFDWVDRVSIEIT 170 Query: 189 TLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSV 248 T + + D + + W + + + + + + Sbjct: 171 TQMLATLFDF---------------PFEERRKLTRWSDVTTAAPGGGVVES-WDQRKTEL 214 Query: 249 KDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAP 308 + +VL E+ + + D + L + ++T E +L +++ Sbjct: 215 LECAAYFQVLWNERVNK-------DPGNDLISMLAHSPATRNMTPEEYLGNVLLLIVGGN 267 Query: 309 DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQP 368 DT S+ + + K+P+ + ++E + E +R+Q Sbjct: 268 DTTRNSMTGGVLALHKNPDQFAKL-----------------KANPALVETMVPEIIRWQT 310 Query: 369 VVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYF 427 + + R A+ D + G ++KG +++ +R E +P EF ++ R Sbjct: 311 PLAHMRRTAIADSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDRPRP----RQH 366 Query: 428 QPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQC 467 FGFG C G +A + ++ + +L RF + + Sbjct: 367 LSFGFGIHRCVGNRLAEMQLRILWEEILTRFSRIEVMAEP 406 >5XW2-A nrPDB Length = 419 Score = 154 bits (389), Expect = 9e-38, Method: Composition-based stats. Identities = 56/367 (15%), Positives = 115/367 (31%), Gaps = 36/367 (9%) Query: 112 YSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTH 171 +SS L + +G + +P + R A + + + Sbjct: 73 FSSHMSRLLPMGADEAFTEGDLLQTDPPDHRELRKLVSHAFTPKVVAELEPRITALT--- 129 Query: 172 LDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKP 231 +E+ + D L+ + L + + + +I + F+ W ++ Sbjct: 130 ----QELLDAVADRDTFDLMTALAY----PLPVTVVAELLSIPSADRHLFEGWMTEIVHS 181 Query: 232 DIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD- 290 + + E+ + + ++ E R + E + D +LI AE G Sbjct: 182 LGDVSMEDAPEDQERIFEAGMAPMRKML-EYLREHAAECRRRPRGDLMGKLIEAEVDGRR 240 Query: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDI 350 LT ++ +LIA T ++ + + + +P + Sbjct: 241 LTDNHIVNFAKMLLIAGYLTTTMLIGNTVLCLDSYPEQAARV-----------------R 283 Query: 351 QKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPK 409 ++ + ESMR+ V R D + G + +++ G +R F + Sbjct: 284 ADRSLIPGLLEESMRFLSPVAATYRATTRDVEVAGQRLSADQMVMVWFGAANRDARQFAE 343 Query: 410 PNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVE 469 P F + FG G C G +A + + L LL RF + Sbjct: 344 PELFDMTRGPNP-----HLGFGRGIHFCLGGPLARMEGRVALDHLLDRFPELYTDPERPP 398 Query: 470 SIQKIHD 476 + D Sbjct: 399 TFMPGFD 405 >4WPZ-A nrPDB Length = 397 Score = 154 bits (388), Expect = 9e-38, Method: Composition-based stats. Identities = 59/380 (15%), Positives = 122/380 (32%), Gaps = 58/380 (15%) Query: 96 IISKSSSMFHIMKHNHYSSRFGSKLGLQ-----CIGMHEKGIIFNNNPELWKTTRPFFMK 150 +++K + + ++ + +SS+ + + + ++ + PE R K Sbjct: 41 MVTKHADVRKVLVDSRFSSKVMATAAAAMSETETGKLMNESLVGMDAPEH-TRLRKLVTK 99 Query: 151 ALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDE 210 A + + + E + LD LE + V + S L +R+ + Sbjct: 100 AFTARRVETLRPRITELVGQLLDELETLPRPVDLVK----------NFSVPLPVRVICEL 149 Query: 211 SAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEE 270 + Q F AW L+ + E + L + LIA KR Sbjct: 150 LGVPAGDQDTFHAWSNALLG------DWQQVVEKEAATVSLVNYFGELIAVKRE------ 197 Query: 271 KLEECMDFATELIL-AEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVE 329 D +ELI ++ LT + + +L A +T + + L + +P Sbjct: 198 --NPADDLISELIAISDGDSTLTEREIIALSIGILSAGHETTANQISMFLVTLLHNPEEL 255 Query: 330 EAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQP---VVDLVMRKALEDDVI-DG 385 + + + + + E +R+ P ++ R + + G Sbjct: 256 DKLRDNREA-----------------IPKAVDELLRFVPLTTTGGIIPRLTTAEVELSGG 298 Query: 386 YPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAM 444 + G ++ + +R E F + FG G C G +A Sbjct: 299 QVLPAGAVVLPAVATANRDPEVFEDGERLNVTRENNP-----HLAFGAGIHHCLGAQLAR 353 Query: 445 VMMKAILVTLLRRFHVKTLQ 464 + ++ L +L R L Sbjct: 354 IELQEALGAILDRMPQVRLA 373 >3SN5-A nrPDB Length = 491 Score = 154 bits (388), Expect = 1e-37, Method: Composition-based stats. Identities = 79/451 (17%), Positives = 154/451 (34%), Gaps = 47/451 (10%) Query: 51 GYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHN 110 G +G + G R +G + G+ I+ S ++ H Sbjct: 20 GLIPYLGCALQFG----ANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHG 75 Query: 111 HYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKT 170 Y L + I + + F+K L G L + E+L+ Sbjct: 76 KYFDWKKFHFALSAKAFGHRSIDPMDGNTT-ENINDTFIKTLQGHALNSLTESMMENLQR 134 Query: 171 HLDR-LEEVTNESGYVD--VLTLLRRVMLDTSN-TLFLRIPLDESAIVVKIQGYFDAWQA 226 + + + + +V + + RVM + T+F R I D ++ Sbjct: 135 IMRPPVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQ 194 Query: 227 L-LIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILA 285 + P + + + + + E L E ++ + +L F + + Sbjct: 195 FDKVFPALVAGLPIHM--FRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTL-- 250 Query: 286 EKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDI 345 + L +L A+ + F+ LF + ++P +A +E++ + Sbjct: 251 ---STFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQ 307 Query: 346 KID-----------DIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI----DGYPVKK 390 K+ ++ L V+++ I ES+R L +R A ED + Y ++K Sbjct: 308 KVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSAS-LNIRTAKEDFTLHLEDGSYNIRK 366 Query: 391 GTNIILNIGRMH-RLEFFPKPNEFTLENFAKN-------------VPYRYFQPFGFGPRG 436 I L MH E +P P F + + Y+ PFG G Sbjct: 367 DDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATI 426 Query: 437 CAGKYIAMVMMKAILVTLLRRFHVKTLQGQC 467 C G+ A+ +K L+ +L F ++ ++GQ Sbjct: 427 CPGRLFAIHEIKQFLILMLSYFELELIEGQA 457 >6FSH-A nrPDB Length = 398 Score = 154 bits (388), Expect = 1e-37, Method: Composition-based stats. Identities = 60/395 (15%), Positives = 133/395 (33%), Gaps = 64/395 (16%) Query: 90 SGEETLIISKSSSMFHIM-KHNHYSSRFGSKLGLQCIGMHEKGII---------FNNNPE 139 E T + + + + ++ H +S+R + + KGI + +P Sbjct: 38 DAETTWLAAGHAVVRQVLGDHQQFSTR---RRWDPRDEIGGKGIFRPRELVGNLMDYDPP 94 Query: 140 LWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTS 199 R + + R+ E + LD +E+ + D++ L + Sbjct: 95 EHTRLRHLLTPGFTQRRMRRLAPRIEEIVTDRLDAMEQAGPPA---DLIELFADEVPGAV 151 Query: 200 NTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSV-KDLKDAIEVL 258 + +P D+ + +K+ + L +K ++ + + Sbjct: 152 LCELIGVPRDDRDMFMKLCHG--------------HLDASLSQKRRAALGDKFSRYLLAM 197 Query: 259 IAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFM 318 IA +R+ + D I+AE +T E + +++++A D +S + Sbjct: 198 IARERK---------DPGDGFIGSIVAEHGDTITDEELRGVCVQLMLAGDDNVSGMIGLG 248 Query: 319 LFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQP-VVDLVMRKA 377 + + +HP A+ + Q+ + + E +RY R A Sbjct: 249 VLALLRHPEQIAALRGDDQSA-----------------DRAVDELIRYLTVPYAPTPRTA 291 Query: 378 LEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQPFGFGPRG 436 +ED ++ +K+G ++ ++ +R P + + FG G Sbjct: 292 VEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTRTPVP-----HVAFGHGIHH 346 Query: 437 CAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESI 471 C G + + ++ L RRF L E + Sbjct: 347 CLGAALTRLQLRIAYTALWRRFPALQLADPAQEIM 381 >5CJE-A nrPDB Length = 393 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 65/422 (15%), Positives = 128/422 (30%), Gaps = 58/422 (13%) Query: 56 IGPLISHGRFLWMGIGSACNYYN--RVYGEFMRVWISGEETL---IISKSSSMFHIMKHN 110 +G +I G + Y R G V E ++ + Sbjct: 1 MGNVIDLGEYGARFTEDPYPVYAELRERGPVHWVRTPPPEAFEGWLVVGHEEARAALADP 60 Query: 111 HYSSRFGSKLGLQC-IGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLK 169 S K + + ++ + PE R +A + + + E Sbjct: 61 RLSKDGTKKGLTSLDVELMGPYLLVVDPPEH-TRLRSLVARAFTMRRVEALRPRIQEITD 119 Query: 170 THLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLI 229 LD + + VD + L + + + + + F A ++ Sbjct: 120 GLLDEMLP-RGRADLVDSF----------AYPLPITVICELLGVPDIDRVTFRALSNEIV 168 Query: 230 KPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRG 289 P + + L ++ LI +KR D +LI Sbjct: 169 APTG-------GDAELAAYERLAAYLDELIDDKRSTA-------PADDLLGDLIRTRAED 214 Query: 290 D--LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKI 347 D L+ E + +L+A +T + + + HP+ A+ Sbjct: 215 DDRLSGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAAL--------------- 259 Query: 348 DDIQKLKVMENFIYESMRYQPVVDLVM-RKALEDDVIDGYPVKKGTNIILNIGRMHRLEF 406 + +++ + E +R++ V+ R A E I G + +G +++ + R Sbjct: 260 --RADMTLLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIAEGDPVMIGLDAAGRDPA 317 Query: 407 -FPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQG 465 P P+ F + + FG G C G +A + + L +LL R L G Sbjct: 318 RHPDPHVFDIHR-----APQGHLAFGHGIHYCLGAPLARLEARVALRSLLERCPDLALDG 372 Query: 466 QC 467 Sbjct: 373 PP 374 >6HQG-A nrPDB Length = 425 Score = 152 bits (384), Expect = 3e-37, Method: Composition-based stats. Identities = 58/403 (14%), Positives = 133/403 (33%), Gaps = 37/403 (9%) Query: 66 LWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCI 125 +W +G + G ++ + M H +SS L Sbjct: 37 MWPYFERLRKEDPVHWGVSPHEDVGGYWSV-TKYNDIMAVDTNHEVFSSEPTIVLP-DPA 94 Query: 126 GMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYV 185 + +P R ++ L + + E LD L + E +V Sbjct: 95 DDFTLPMFIAMDPPKHDVQRKTVQPIVAPNHLAYLEPIIRERAGKILDDL-PIGEEINWV 153 Query: 186 DVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYE 245 D +++ + T TLF + + W + + + Sbjct: 154 DKVSI--ELTTMTLATLF--------DFPWEDRRKLTFWSDVATSAPESGILGTTDPEEH 203 Query: 246 KSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLI 305 ++++ + + + R + D + L E ++ R ++ +++ Sbjct: 204 ENLR--RQTLFECVDYFMRLWNERVNAPPKPDLISMLAHGESTKNMDRMEYLGNLILLIV 261 Query: 306 AAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMR 365 DT ++ + + ++P+ + + + ++ + E++R Sbjct: 262 GGNDTTRNTISGSVLALHQNPDQDRKLRE-----------------NPGLIPAMVSETIR 304 Query: 366 YQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENFAKNVPY 424 +Q + + R+A D + G +++G + + +R E +PN++ +E Sbjct: 305 WQTPLAYMRRRAKRDFELGGKTIREGDKVAMWYVSGNRDEEVIDRPNDYWIERPR----V 360 Query: 425 RYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQC 467 R FGFG C G +A + +K I +L RF + G Sbjct: 361 RQHLSFGFGVHRCVGNRLAELQLKIIWEEILARFPRLEVVGPP 403 >1UED-A nrPDB Length = 406 Score = 152 bits (384), Expect = 3e-37, Method: Composition-based stats. Identities = 77/420 (18%), Positives = 138/420 (32%), Gaps = 59/420 (14%) Query: 75 NYYNRVYGEFMRVWISGEETL------IISKSSSMFHIM-KHNHYSSR--FGSKLGLQCI 125 N+ R +G +R+ L + I+ H H+++R F + Sbjct: 30 NFGLRAHGPLVRIVGESSTQLGRDFVWQAHGYEVVRRILGDHEHFTTRPQFTQSKSGAHV 89 Query: 126 GMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYV 185 G I +P R + + RM + LD LE E Sbjct: 90 EAQFVGQISTYDPPEHTRLRKMLTPEFTVRRIRRMEPAIQSLIDDRLDLLEA---EGPSA 146 Query: 186 DVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYE 245 D+ L + + L IP D+ V+ L K Sbjct: 147 DLQGLFADPVGAHALCELLGIPRDDQREFVRRIRRNADLSRGL-------------KARA 193 Query: 246 KSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLI 305 ++ L+A +R + D +I+ + ++T E + +++ Sbjct: 194 ADSAAFNRYLDNLLARQRA---------DPDDGLLGMIVRDHGDNVTDEELKGLCTALIL 244 Query: 306 AAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMR 365 +T++ + F + + +P E + + + E + E +R Sbjct: 245 GGVETVAGMIGFGVLALLDNPGQIELLFESPEKA-----------------ERVVNELVR 287 Query: 366 YQPVVDL-VMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEFTLENFAKNVP 423 Y V R A++D VIDG +K G ++ +I +R E P P+ A + Sbjct: 288 YLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDPDVLDANRAAVSD- 346 Query: 424 YRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDE 483 FG G C G +A M++ TL RRF L +E ++ PD+ Sbjct: 347 ----VGFGHGIHYCVGAALARSMLRMAYQTLWRRFPGLRLA-VPIEEVKYRSAFVDCPDQ 401 >3TKT-A nrPDB Length = 450 Score = 151 bits (380), Expect = 9e-37, Method: Composition-based stats. Identities = 61/328 (18%), Positives = 108/328 (32%), Gaps = 35/328 (10%) Query: 143 TTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTL 202 R L R+ + +DR+ E ++ ++ L + Sbjct: 134 KLRRLTQDWFMPKNLARLDGEIRKIANEAIDRMLGAGEEGDFMALVAA--PYPLHVVMQI 191 Query: 203 FLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKK-YEKSVKDLKDAIEVLIAE 261 P DE ++ Q F + K + + +V + + L AE Sbjct: 192 LGVPPEDEPKMLFLTQQMFGGQDEDMNKSGLKDLPPEQISQIVAGAVAEFERYFAGLAAE 251 Query: 262 KRRRISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAAPDTMSVSLFFMLF 320 +RR D AT + A G+ ++ + + A DT S S Sbjct: 252 RRR--------NPTDDVATVIANAVVDGEPMSDRDTAGYYIITASAGHDTTSASSAGAAL 303 Query: 321 LIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALED 380 +A+ P++ + ++ + E++R+ V MR A D Sbjct: 304 ALARDPDLFARV-----------------KADRNLLPGIVEEAIRWTTPVQHFMRTAATD 346 Query: 381 DVIDGYPVKKGTNIILNI-GRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAG 439 + G + G ++LN H FP+P +F P FG G C G Sbjct: 347 TELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTR-----PANRHLAFGAGSHQCLG 401 Query: 440 KYIAMVMMKAILVTLLRRFHVKTLQGQC 467 ++A + M+ +L LL R L G+ Sbjct: 402 LHLARLEMRVLLDVLLDRVDSLELAGEP 429 >3TYW-A nrPDB Length = 417 Score = 150 bits (379), Expect = 1e-36, Method: Composition-based stats. Identities = 69/395 (17%), Positives = 133/395 (33%), Gaps = 59/395 (14%) Query: 83 EFMRVWI-SGEETLIISKSSSMFHIMKHNHYSSR-----FGSKL-GLQCIGMHEKGIIFN 135 RV + + E ++++ + ++ S+ F + G Q G + I Sbjct: 43 PVARVTLPTRREAWVVTRYDDVRELLSDPRVSADIRRPGFPALGEGEQEAGARFRPFIRT 102 Query: 136 NNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVM 195 + PE R + A + + M + LD + G VD+++ + Sbjct: 103 DAPEH-TRYRRMLLPAFTVRRVRAMRPAVQARVDEILDGMLAA---GGPVDLVSAYANAV 158 Query: 196 LDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAI 255 + L IP + + ++ +++ L + Sbjct: 159 STSVICELLGIP-RHDLEFFRDVTRISGSRN------------STAEQVSEALGGLFGLL 205 Query: 256 EVLIAEKRRRISTEEKLEECMDFATELILAEK--RGDLTRENVNQCILEMLIAAPDTMSV 313 L+AE+R EE D ++ + G++T E + + + A +T + Sbjct: 206 GGLVAERR---------EEPRDDLISKLVTDHLVPGNVTTEQLLSTLGITINAGRETTTS 256 Query: 314 SLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLV 373 + L+ P + + K+ +M + E +R V D + Sbjct: 257 MIALSTLLLLDRPELPAELRKDPD-----------------LMPAAVDELLRVLSVADSI 299 Query: 374 M-RKALEDDVIDGYPVKKGTNIILNI-GRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFG 431 R A ED + G V +I + G H E F P + FG Sbjct: 300 PLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHRTDN-----HHVAFG 354 Query: 432 FGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQ 466 +G C G+++A + ++ L TLLRR L G+ Sbjct: 355 YGVHQCVGQHLARLELEVALETLLRRVPTLRLAGE 389 >4MM0-A nrPDB Length = 399 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 61/378 (16%), Positives = 128/378 (33%), Gaps = 49/378 (12%) Query: 90 SGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFM 149 +G+ ++++ + ++ +S R + M + ++ + P R Sbjct: 43 TGDPGFLVTRYEDVRFVLSDPRFSVRQDLPGAPRLTEMTFESVMTTDPPVH-TRLRRLLS 101 Query: 150 KALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLD 209 + + + RM E + LD +E+ + V+ L + + + + Sbjct: 102 RDFTARRIERMRPRLEEIAEGLLDEMEKKGAPADIVESLAV----------PFPITVICE 151 Query: 210 ESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTE 269 + + F W ++ + W + L+ ++ L+A KR Sbjct: 152 LLGVPMVDVARFRGWADTMVSLTGYSMEDW-----TAARDALESYLDGLVAAKRE----- 201 Query: 270 EKLEECMDFATELIL-AEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNV 328 D + L+ A + +LT +V L +L+A + S L + + + P+ Sbjct: 202 ---NPGSDLLSALVATAAEDNELTDHDVRSLSLILLLAGYEPASNQLGSSVLTLLRFPDR 258 Query: 329 EEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDGYP 387 + + ++ + + E MRY P D + R LED I Sbjct: 259 LAEL-----------------RRDPGLLPSAVEELMRYAPAGDGALFRVTLEDVTIGDTH 301 Query: 388 VKKGTNIILNIGRMH-RLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVM 446 + + ++ + + F P L+ P G G C G +A V Sbjct: 302 IPANSAVLASTQAANWDPRRFDDPTGLRLDR-----PDNQHTALGHGIHFCLGAALARVE 356 Query: 447 MKAILVTLLRRFHVKTLQ 464 ++ + LLRRF L Sbjct: 357 LQVAIGALLRRFPRLALA 374 >6FYJ-A nrPDB Length = 421 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 61/392 (15%), Positives = 132/392 (33%), Gaps = 48/392 (12%) Query: 84 FMRVWISGEETLIISKSSSMFHIMKHNHYS--SRFGSKLGLQCIGMHEKGIIFNNNPELW 141 + G++ + + + + +++ G + G+ + Sbjct: 40 IFETRLLGKKAICMGGKEAAEIFYDTEKFKRKDAAPNRVVQTLFG--KNGVQALDGQT-- 95 Query: 142 KTTRP-FFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSN 200 R FM +S L ++ + + + +D+ E++ Y + ++ R Sbjct: 96 HKHRKEMFMSIMSPDELEKLTDITKKQWEIAVDKWEQMDKVILYEEAKEIMCRTA----- 150 Query: 201 TLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIA 260 + +P+ E+ + + + + + + YE+ IE LI Sbjct: 151 CQWAGVPVQENEVKRLTKNLGAMF-ESAAAVGLKHWLGRHARNYEEI------WIEELID 203 Query: 261 EKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLF 320 R + E + G+L +E++ +++++F Sbjct: 204 ---RVRDGKVNPPENTTLHKFSWYRDLEGNLLDTE--TAAVEVINILRPIVAIAIFINFI 258 Query: 321 LIAKH--PNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKAL 378 +A H P +E + K + F+ E R+ P V+ Sbjct: 259 ALALHHYPEEKEKL----------------KSGDKKYSQMFVQEVRRFYPFFPFVVALVK 302 Query: 379 EDDVIDGYPVKKGTNIILNIG-RMHRLEFFPKPNEFTLENFAK-NVPYRYFQPFGFGP-- 434 +D GY ++GT +L++ H E + P+ F+ + FAK F P G G Sbjct: 303 KDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDRFAKWEGSPFSFIPQGGGDYF 362 Query: 435 --RGCAGKYIAMVMMKAILVTLLRRFHVKTLQ 464 CAG+++ + +MK L L R + Sbjct: 363 MGHRCAGEWVTIEVMKVSLDYLTNRMDYEVPD 394 >5FYF-A nrPDB Length = 470 Score = 149 bits (375), Expect = 3e-36, Method: Composition-based stats. Identities = 72/414 (17%), Positives = 134/414 (32%), Gaps = 53/414 (12%) Query: 56 IGPLISHGRFLWMG-------IGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMK 108 + + + W N +G F V E+ L + KS Sbjct: 70 VSNPFLYRQGQWRAYFKRLRDEAPVHYQKNSPFGPFWSVTRF-EDILFVDKS-------- 120 Query: 109 HNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESL 168 H+ +S+ LG G+ + + +P R ++ L M + Sbjct: 121 HDLFSAEPQIILGDPPEGLSVE-MFIAMDPPKHDVQRSSVQGVVAPKNLKEMEGLIRSRT 179 Query: 169 KTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALL 228 LD L + V L ML T ++ G A Sbjct: 180 GDVLDSLPTDKPFNWVPAVSKELTGRMLATLLDFPYEERHKLVEWSDRMAGAASATGGEF 239 Query: 229 IKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKR 288 + F D+ + L +K R + E E D + L ++ Sbjct: 240 ADENAMF----------DDAADMARSFSRLWRDKEARRAAGE--EPGFDLISLLQSNKET 287 Query: 289 GDL--TRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIK 346 DL + +++ DT S+ L + + P E + Sbjct: 288 KDLINRPMEFIGNLTLLIVGGNDTTRNSMSGGLVAMNEFPREFEKL-------------- 333 Query: 347 IDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE- 405 K +++ N + E +R+Q + + R A +D + G +KKG +++ +R E Sbjct: 334 ---KAKPELIPNMVSEIIRWQTPLAYMRRIAKQDVELGGQTIKKGDRVVMWYASGNRDER 390 Query: 406 FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFH 459 F P++F ++ R FG+G C G +A + ++ + +L+RF Sbjct: 391 KFDNPDQFIIDR----KDARNHMSFGYGVHRCMGNRLAELQLRILWEEILKRFD 440 >6HQD-A nrPDB Length = 420 Score = 148 bits (374), Expect = 4e-36, Method: Composition-based stats. Identities = 65/414 (15%), Positives = 137/414 (33%), Gaps = 60/414 (14%) Query: 78 NRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNN- 136 YG + + + I + + +H + F L + + GI N Sbjct: 52 ASEYGPYWSITKFSDIVAIDTNH----KVFSSDHTNGSFV--LDDTTLNAVDGGIYLPNF 105 Query: 137 ---NPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRL----EEVTNESGYVDVLT 189 +P R ++ L+R E K L L E + +++ T Sbjct: 106 LGMDPPKHDVHRMVVSPIVAPQNLLRFEATIRERTKRVLSELPIGEEFNWVDRVSIELTT 165 Query: 190 LLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVK 249 ++ +LD + W ++ + + +++ E + Sbjct: 166 MMLATLLDF---------------PFDDRRKLTRWSDIITTRPGYGLV-DSWEQRESELM 209 Query: 250 DLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPD 309 + + L AE+ + + D + L + + DLT + + +++ D Sbjct: 210 ECLAYFQRLYAER-------QAMPPKPDLISMLAHSPEMQDLTPTDFLGTLALLIVGGND 262 Query: 310 TMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPV 369 T S+ +P + + ++ + I E +R+Q Sbjct: 263 TTRSSMSGSAMACHLYPQEFDKV-----------------RNNRALLASVIPEVVRWQTP 305 Query: 370 VDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYFQ 428 + + R ALED G ++KG +++ +R E +P +F + R+ Sbjct: 306 IAHMRRTALEDVEFRGKQIRKGDKVVMWYLSGNRDDEVIDRPMDFIADRPR----ARHHL 361 Query: 429 PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCV-ESIQKIHDLSLHP 481 FGFG C G +A + +K + + R+ + G+ V +H P Sbjct: 362 SFGFGIHRCLGNRLAELQLKILWEEMCERYSRIEVCGEPVRVPSNLVHGYIDIP 415 >3A50-A nrPDB Length = 411 Score = 148 bits (373), Expect = 6e-36, Method: Composition-based stats. Identities = 50/327 (15%), Positives = 116/327 (35%), Gaps = 50/327 (15%) Query: 132 IIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLL 191 ++ +P R ++ + + + E L L G VD+ Sbjct: 86 MMILMDPPDHTRLRKLVGRSFTVRRMNELEPRITEIADGLLAGLP----TDGPVDL---- 137 Query: 192 RRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDL 251 M + + + +++ + + + + F AW ++L+ ++ L Sbjct: 138 ---MREYAFQIPVQVICELLGLPAEDRDDFSAWSSVLVDDSPADDK-------NAAMGKL 187 Query: 252 KDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAAPDT 310 + L+ KR + ++ L +++ GD L++E + + +LIA +T Sbjct: 188 HGYLSDLLERKR-------TEPDDALLSSLLAVSDMDGDRLSQEELVAMAMLLLIAGHET 240 Query: 311 MSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRY-QPV 369 + + + HP+ + ++ E ++ + + E +R+ PV Sbjct: 241 TVNLIGNGVLALLTHPD-QRKLLAE----------------DPSLISSAVEEFLRFDSPV 283 Query: 370 VDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFF-PKPNEFTLENFAKNVPYRYFQ 428 +R ED G + G ++L + +R + P+P+ + A + Sbjct: 284 SQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDASGGVF---- 339 Query: 429 PFGFGPRGCAGKYIAMVMMKAILVTLL 455 FG G C G +A + + + L Sbjct: 340 -FGHGIHFCLGAQLARLEGRVAIGRLF 365 >5NWS-A nrPDB Length = 435 Score = 147 bits (371), Expect = 9e-36, Method: Composition-based stats. Identities = 60/342 (17%), Positives = 114/342 (33%), Gaps = 46/342 (13%) Query: 131 GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 190 G I +++P R +A + ++ + L L E G VD+L Sbjct: 113 GSILDSDPPDHPRLRRLVTRAFAARRILGLRPGIERIADRLLAELPRREEEDGTVDLLE- 171 Query: 191 LRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKD 250 + L + + + I + W L +S ++ S Sbjct: 172 ------HFAYPLSITVICELVGIPATDLERWREWGGDL--------VSMRPERLRHSFPV 217 Query: 251 LKDAIEVLIAEKRRRISTEEKLEECMDFATELILA--EKRGDLTRENVNQCILEMLIAAP 308 + D LI ++R ++ D +ELI A + G L+ IL +++A Sbjct: 218 MIDYCHRLIEQRRAALTD--------DLLSELIRAQDDDGGRLSDIETVTMILTLVLAGH 269 Query: 309 DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQP 368 +T + + + HP + K+ ++ ++E MR+ Sbjct: 270 ETSAHLIGNGTAALLTHPGQWALLRKD-----------------PALLPRAVHELMRWCG 312 Query: 369 VVDLV-MRKALEDDVIDGYPVKKGTNIILNIGRMH-RLEFFPKPNEFTLENFAKNVPYRY 426 V + +R A ED + G PV +G + L + + + P+ + + Sbjct: 313 SVHVARLRYATEDLELAGTPVARGDAVQLVLVSANFDPRHYSDPDRLDITR-HQEGQAEN 371 Query: 427 FQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF-HVKTLQGQC 467 FG G C G +A + L LL + + G Sbjct: 372 HVGFGHGIHYCLGATLARQEGEVALARLLETYPDLALADGDP 413 >5LIE-A nrPDB Length = 414 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 56/358 (15%), Positives = 116/358 (32%), Gaps = 54/358 (15%) Query: 112 YSSRFGSKL-----GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAE 166 YSS G + LQ + + + + ++P R L+ + R+ Sbjct: 70 YSSVTGGQRRFGGTVLQDLPVAGQVLNMMDDPRH-TRIRRLVSSGLTPRMIRRVEDDLRR 128 Query: 167 SLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQA 226 + LD +E D + +P+ I++ + W Sbjct: 129 RARGLLDGVEP---------------GAPFDFVVEIAAELPMQMICILLGVPETDRHWLF 173 Query: 227 LLIKPDIFFK----ISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATEL 282 ++P F+ + E + L LIA KR + ++ + Sbjct: 174 EAVEPGFDFRGSRRATMPRLNVEDAGSRLYTYALELIAGKRAEPA-----DDMLSVVANA 228 Query: 283 ILAEKRGD-LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG 341 + + L+ + + A +T S+ L +A++P+ + + Sbjct: 229 TIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTL--------- 279 Query: 342 ERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRM 401 +++ I E +R+ R A + G P++ G +++ G Sbjct: 280 --------RSDFELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSA 331 Query: 402 HR-LEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRF 458 +R F + +EF + FG G C G +A + ++ + LL RF Sbjct: 332 NRDPSVFDRADEFDITRKPNP-----HLGFGQGVHYCLGANLARLELRVLFEELLSRF 384 >3MGX-A nrPDB Length = 415 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 60/358 (16%), Positives = 117/358 (32%), Gaps = 50/358 (13%) Query: 113 SSRFGSKLGLQCIGMHEKG--IIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKT 170 +S +G +G G ++ + E + R LS ++ + Sbjct: 84 TSEYGMMIGFDRDHPDNSGGRMMVVSEHEQHRKLRKLVGPLLSRAAARKLAERVRIEVGD 143 Query: 171 HLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIK 230 L R+ + E D T + + L +P ++ ++ D Sbjct: 144 VLGRV--LDGEV--CDAATAIGPRIPAAVVCEILGVPAEDEDML------IDLTNHAFGG 193 Query: 231 PDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD 290 D F ++ ++ + LI +R+ E D + L+ D Sbjct: 194 EDELFD----GMTPRQAHTEILVYFDELITARRK--------EPGDDLVSTLV---TDDD 238 Query: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDI 350 LT ++V +LI +T ++ + +A P + A+ V Sbjct: 239 LTIDDVLLNCDNVLIGGNETTRHAITGAVHALATVPGLLTALRDGSADV----------- 287 Query: 351 QKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPK 409 + + E +R+ V+R D I+G + GT ++ + +R F Sbjct: 288 ------DTVVEEVLRWTSPAMHVLRVTTADVTINGRDLPSGTPVVAWLPAANRDPAEFDD 341 Query: 410 PNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQC 467 P+ F P R+ FG G C G +A + + +L L R L+ + Sbjct: 342 PDTFLPGR----KPNRHIT-FGHGMHHCLGSALARIELSVVLRVLAERVSRVDLEREP 394 >6M7L-A nrPDB Length = 404 Score = 145 bits (365), Expect = 5e-35, Method: Composition-based stats. Identities = 58/399 (14%), Positives = 122/399 (30%), Gaps = 59/399 (14%) Query: 82 GEFMRVWISGEETL--IISKSSSMFHIMKHNHYSSRFGS-KLGLQCIGMHEKGIIFNNNP 138 G +R+ + + + ++ + R Q + + + + Sbjct: 48 GPLVRIPLEDGSAVHWFALGYDVVREVLGSEKFDKRVIGTHFNHQEMALPGNLLQLDPPE 107 Query: 139 ELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDT 198 R A S + + + HLD + + V+ L + M Sbjct: 108 HT--RLRRMVAPAYSVRRMQALEPRVQAIVDDHLDTM---ASTGPPVEFLREVAGPMAAR 162 Query: 199 SNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVL 258 FL IPLD+ ++++ + + + L Sbjct: 163 VACEFLGIPLDDRGELIRL---------------TAHRGGKRRRVLNGH--AYLAYMREL 205 Query: 259 IAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFM 318 A RR + D ++ + D++ E + ++ ++ + L Sbjct: 206 AARLRR---------DPGDGMLGMVARDHGADISDEELAGLCAVVMNSSVEQTESCLAAG 256 Query: 319 LFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLV-MRKA 377 L+ +HP + + + ++ E + E +RY V + + R A Sbjct: 257 TLLLLEHPEQFALLRE-----------------RPELGEQAVEEIVRYLSVFEGLDPRTA 299 Query: 378 LEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGC 437 ED I G +KKG + ++ +R + P + F + FG G C Sbjct: 300 TEDVEIGGQVIKKGEAVFCSLLAANRAD--PALDGFDITR-----KESRHVAFGHGIHHC 352 Query: 438 AGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHD 476 G +A + ++ TL+ RF E + Sbjct: 353 LGAPLARMELRIAFTTLVSRFPSLRTAVPAEEIRFRPPS 391 >1Q5D-A nrPDB Length = 419 Score = 144 bits (364), Expect = 6e-35, Method: Composition-based stats. Identities = 68/412 (16%), Positives = 139/412 (33%), Gaps = 46/412 (11%) Query: 81 YGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPEL 140 Y + R W+ + + + + S + + +K +F PE Sbjct: 43 YWDEGRSWVLTRYHDVSAVFRDERFAVSREEWESSAEYSSAIPELSDMKKYGLFGLPPED 102 Query: 141 WKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSN 200 R + + R + + ++ +D+L + + DV+ + + Sbjct: 103 HARVRKLVNPSFTS----RAIDLLRAEIQRTVDQLLDARSGQEEFDVVRDYAEGIPMRAI 158 Query: 201 TLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIA 260 + L++P + + + + P + + L + + L ++ Sbjct: 159 SALLKVPAECDEKFRRFGSATARALGVGLVPRVDEETKTLVASVTEGLALLHGVLDE--- 215 Query: 261 EKRRRISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAAPDTMSVSLFFML 319 RRR E D T L+ AE G L+ + + + ++ A DT + F + Sbjct: 216 --RRRNPLEN------DVLTMLLQAEADGSRLSTKELVALVGAIIAAGTDTTIYLIAFAV 267 Query: 320 FLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVV-DLVMRKAL 378 + + P E + E +M N + E +R+ ++ +R A Sbjct: 268 LNLLRSPEALELVKAEPG-----------------LMRNALDEVLRFDNILRIGTVRFAR 310 Query: 379 EDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGC 437 +D G +KKG + L I R F +P+ F + +G GP C Sbjct: 311 QDLEYCGASIKKGEMVFLLIPSALRDGTVFSRPDVFDVRR-----DTSASLAYGRGPHVC 365 Query: 438 AGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIH------DLSLHPDE 483 G +A + + + T+ RRF L+ V ++ L P + Sbjct: 366 PGVSLARLEAEIAVGTIFRRFPEMKLKETPVFGYHPAFRNIESLNVILKPSK 417 >1ODO-A nrPDB Length = 408 Score = 144 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 69/409 (16%), Positives = 135/409 (33%), Gaps = 54/409 (13%) Query: 82 GEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGL--QCIGMHEKGI------I 133 G V + G + +S + ++ + S + + +G + + Sbjct: 28 GPATWVDVLGVQAWSVSDPVLLKQLLTSSDVSKDARAHWPAFGEVVGTWPLALWVAVENM 87 Query: 134 FNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRR 193 F + R A S + M + +DRL E+ VD+ L Sbjct: 88 FTAYGPNHRKLRRLVAPAFSARRVDAMRPAVEAMVTGLVDRLAELP-AGEPVDLRQEL-- 144 Query: 194 VMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKD 253 + L + + + + F A D F + + + + L + Sbjct: 145 -----AYPLPIAVIGHLMGVPQDRRDGFRAL------VDGVFDTTLDQAEAQANTARLYE 193 Query: 254 AIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAAPDTMS 312 ++ LIA KR ++ E GD L+ E + +L M+ A +T Sbjct: 194 VLDQLIAAKRATPG-----DDMTSLLIAARDDEGDGDRLSPEELRDTLLLMISAGYETTV 248 Query: 313 VSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVV-D 371 + + + P+ + K ++ D + E++R++P V Sbjct: 249 NVIDQAVHTLLTRPDQLALVRKG--------EVTWAD---------VVEETLRHEPAVKH 291 Query: 372 LVMRKALEDDVI-DGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYFQP 429 L +R A+ D + DG + +G I+ + +R ++ + F K Sbjct: 292 LPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHEDADTFDATRTVKE-----HLA 346 Query: 430 FGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLS 478 FG G C G +A + + L +L RF L E + + L Sbjct: 347 FGHGVHFCLGAPLARMEVTLALESLFGRFPDLRLA-DPAEELPPVPSLI 394 >6F0B-A nrPDB Length = 395 Score = 144 bits (362), Expect = 1e-34, Method: Composition-based stats. Identities = 67/394 (17%), Positives = 134/394 (34%), Gaps = 54/394 (13%) Query: 91 GEETLIISKSSSMFHIMKHNHYSSRF--GSKLGLQCIGMHEKGI--IFNNNPELWKTTRP 146 G + S + +++ +SS + L + + + R Sbjct: 37 GTPAHVFSGYEDVRTVLQDRRFSSDSRRPNFTELTPTLQSQAAAPPFVRTDNPDHRRLRG 96 Query: 147 FFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRI 206 + + + E ++ LD L E D+L + + L I Sbjct: 97 TIAREFLPKHIELLRPAIREIVQGVLDGLAETAPPQ---DMLEAFAVPVASATVFRLLGI 153 Query: 207 PLDESAIVVK-IQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRR 265 P ++ A++ + ++G A + ++F + L + I L+ + Sbjct: 154 PAEDRALLTRCVKGVVSAVGSEDEGAEVF--------------RTLGEYIGGLVQD---- 195 Query: 266 ISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKH 325 +L E + + LT IL +++ DT + ++ L A Sbjct: 196 ---PSELPEDSLIRRLVTGPYQEKQLTFHETIGVILMLIVGGYDTTASTISLSLVSYALQ 252 Query: 326 PNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDL-VMRKALEDDVID 384 P + + + + + E +RY V L + R A ED + Sbjct: 253 PEKFSVVHEHPER-----------------IPLLVEELLRYHTVSQLGLGRIATEDVEVG 295 Query: 385 GYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIA 443 G V+ G ++ + +R E FP P+E + P FG+GP C G+ +A Sbjct: 296 GVTVRAGQMVVAALPLANRDESVFPNPDELDFDR-----PSVPHVGFGYGPHQCVGQALA 350 Query: 444 MVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDL 477 V ++ + ++RR L +E + HD+ Sbjct: 351 RVELQEAIPAVIRRLPGMRLA-CALEDLPFRHDM 383 >2WM5-A nrPDB Length = 435 Score = 143 bits (361), Expect = 1e-34, Method: Composition-based stats. Identities = 55/388 (14%), Positives = 126/388 (32%), Gaps = 47/388 (12%) Query: 97 ISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPG 156 S+ +F + Y + + + I+ ++ + R +A + Sbjct: 88 ASRHPDIF-----SSYPNITINDQTPELAEYFGSMIVLDD--PRHQRLRSIVSRAFTPKV 140 Query: 157 LVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVK 216 + R+ + + + N D+++ L L L+I D I Sbjct: 141 VARIEAAVRDRAHRLVSSMIA-NNPDRQADLVSELAG-------PLPLQIICDMMGIPKA 192 Query: 217 IQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECM 276 W +++ F L +++ ++ D I ++ + ++ Sbjct: 193 DHQRIFHWTNVILG----FGDPDLATDFDEFMQVSAD-----IGAYATALAEDRRVNHHD 243 Query: 277 DFATELILAEKRGD-LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKE 335 D + L+ AE G+ L+ + + +++A +T ++ + ++++P + + Sbjct: 244 DLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAITHGVLALSRYPEQRDRWWSD 303 Query: 336 IQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNII 395 + + E +R+ V + R +D + G + G + Sbjct: 304 FDG----------------LAPTAVEEIVRWASPVVYMRRTLTQDIELRGTKMAAGDKVS 347 Query: 396 LNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTL 454 L +R E F P F L P + G G C G +A ++ L Sbjct: 348 LWYCSANRDESKFADPWTFDLAR----NPNPHLGFGGGGAHFCLGANLARREIRVAFDEL 403 Query: 455 LRRFHVKTLQGQCVESI-QKIHDLSLHP 481 R+ + + Q IH + P Sbjct: 404 RRQMPDVVATEEPARLLSQFIHGIKTLP 431 >3A1L-A nrPDB Length = 425 Score = 143 bits (360), Expect = 2e-34, Method: Composition-based stats. Identities = 52/325 (16%), Positives = 101/325 (31%), Gaps = 41/325 (12%) Query: 132 IIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLL 191 ++F + P R S + + AE LDRL D++ Sbjct: 98 LVFLDPPHH-TELRSLLTTEFSPSIVTGLRPRIAELASALLDRLRAQRRP----DLVEGF 152 Query: 192 RRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDL 251 + L + + I + L + S + + Sbjct: 153 -------AAPLPILVISALLGIPEEDH------TWLRANAVALQEASTTRARDGRGYARA 199 Query: 252 KDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTM 311 + A + RR + + + + L+ + + + +L A +T Sbjct: 200 EAASQEFTRYFRREVDRRGGDDRDDLLTLLVRARDTGSPLSVDGIVGTCVHLLTAGHETT 259 Query: 312 SVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVD 371 + L + + H +V + + ++ + E MRY P V Sbjct: 260 TNFLAKAVLTLRAHRDVLDELRTTPES-----------------TPAAVEELMRYDPPVQ 302 Query: 372 LVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEF-FPKPNEFTLENFAKNVPYRYFQPF 430 V R A ED + + + +G+ ++ +G +R FP P+ + A+ F Sbjct: 303 AVTRWAYEDIRLGDHDIPRGSRVVALLGSANRDPARFPDPDVLDVHRAAERQ-----VGF 357 Query: 431 GFGPRGCAGKYIAMVMMKAILVTLL 455 G G C G +A + L LL Sbjct: 358 GLGIHYCLGATLARAEAEIGLRALL 382 >4XE3-A nrPDB Length = 407 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 66/422 (15%), Positives = 136/422 (32%), Gaps = 60/422 (14%) Query: 70 IGSACNYYNRVYGEFMRVWI-SGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMH 128 R RV + GE T + S I+ + SRF + Sbjct: 26 DLDPHYAELRRDEPVSRVRLPYGEGTAWLVTRMSDARIVLGD---SRFSTAAATDPATPR 82 Query: 129 ------EKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNES 182 E + +P R KA + + M + + LD + + + Sbjct: 83 MFPTPPEPDGVLAQDPPDHTRLRRLVGKAFTARRVEEMRPRVRSLVDSLLDDMVAHGSPA 142 Query: 183 GYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYK 242 V+ L + + + + + ++ + F + ++ Sbjct: 143 DLVEFLAV----------PFPVAVICELLGVPLEDRDLFRTFSDAMLS-----STRLTAA 187 Query: 243 KYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD-LTRENVNQCIL 301 + ++ +D ++ L+A++R D L LA D LT+ + + Sbjct: 188 EIQRVQQDFMVYMDGLVAQRR--------DAPTEDLLGALALATDNDDHLTKGEIVNMGV 239 Query: 302 EMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIY 361 +LIA +T + ++ L+ E + + + ++ + Sbjct: 240 SLLIAGHETSVNQITNLVHLLLT----ERKRYESL-------------VADPALVPAAVE 282 Query: 362 ESMRYQPVVD--LVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENF 418 E +RY P+V +R A ED + V+ G +++ +R E F +E Sbjct: 283 EMLRYTPLVSAGSFVRVATEDVELSTVTVRAGEPCVVHFASANRDEEVFDHADELDFHRE 342 Query: 419 AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLS 478 FG G C G + + ++ L L+RRF L + V ++ + Sbjct: 343 RNP-----HIAFGHGAHHCIGAQLGRLELQEALSALVRRFPTLDLA-EPVAGLKWKQGML 396 Query: 479 LH 480 + Sbjct: 397 IR 398 >5YSW-A nrPDB Length = 441 Score = 142 bits (358), Expect = 3e-34, Method: Composition-based stats. Identities = 65/391 (16%), Positives = 124/391 (31%), Gaps = 51/391 (13%) Query: 83 EFMRVWISGEETLIISKSS-SMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELW 141 F V E ++S S H + G N +P Sbjct: 76 PFWLVSGYEEARAVLSDPRFSSDRFQYHPWFKELSPEFRERLRDDKARAGSFINMDPPEH 135 Query: 142 KTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNT 201 R + + R+ + A + R++ + D++T Sbjct: 136 TRYRKLLTGQFT---VRRIRELGARIDEIVAGRVDAMLAGGTTADLMTEFAFPAPSLMIC 192 Query: 202 LFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAE 261 L + ++ A + + +++ + K+ L+ ++ L+ + Sbjct: 193 ELLGVRYEDRAEFQQ-------------RASALLQMNAPVAEAVKNADALRAFMQALVTD 239 Query: 262 KRRRISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAAPDTMSVSLFFMLF 320 KR + D + LI LT + + +LIA DT + L +F Sbjct: 240 KRANPAG--------DIISGLIHHAGADPALTDDELINIANLLLIAGYDTTASMLGLGIF 291 Query: 321 LIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVV-DLVMRKALE 379 ++ + P + + + + E +RY VV + R A E Sbjct: 292 VLLQRPAQLATLRDDPSRIAD-----------------AVEELLRYLSVVNPGIFRFAKE 334 Query: 380 DDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCA 438 D G + G+ +++++ +R +P P+ L P FG G C Sbjct: 335 DLEFAGEHIPAGSTVVVSVVATNRDARHWPDPD-LDLTR-----PRGPHLAFGHGVHQCL 388 Query: 439 GKYIAMVMMKAILVTLLRRFHVKTLQGQCVE 469 G+ +A + M+A LLRR L E Sbjct: 389 GQQLARMEMQAGYAELLRRLPNVRLAVPPEE 419 >1WIY-A nrPDB Length = 389 Score = 142 bits (358), Expect = 3e-34, Method: Composition-based stats. Identities = 59/396 (14%), Positives = 121/396 (30%), Gaps = 57/396 (14%) Query: 93 ETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKAL 152 +I + + + L + +G+ + + WK R Sbjct: 42 PLALIFDPEGVEGALLAEGTTKATFQYRALS--RLTGRGL-LTDWGKSWKEARKALKDPF 98 Query: 153 SGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESA 212 + E D+ + + L PL S Sbjct: 99 LPKSVRGYREAMEEEAWAFFGEWR-----GEERDLDHEMLALSLRLLGRALFGKPLSPS- 152 Query: 213 IVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKL 272 + D A P ++ + + ++A Sbjct: 153 LAEHALKALDRIMAQTRSPLALLDLAAEARFRKDRGALYREA------------------ 194 Query: 273 EECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAI 332 LI+ L RE + +L+A +T++ +L + L++ P+ ++ + Sbjct: 195 -------EALIVHPPLSHLPRERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRV 247 Query: 333 IKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGT 392 + + + E++R P ++ R+ ++ + +GT Sbjct: 248 AESEEAALAA-----------------FQEALRLYPPAWILTRRLERPLLLGEDRLPQGT 290 Query: 393 NIILNIGRMHRLEFFPKPNEFTLENF--AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAI 450 ++L+ RL +FP+ F E F + P + PFG G R C G+ A++ + Sbjct: 291 TLVLSPYVTQRL-YFPEGEAFQPERFLAERGTPSGRYFPFGLGQRLCLGRDFALLEGPIV 349 Query: 451 LVTLLRRFHVKTLQGQCV---ESIQKIHDLSLHPDE 483 L RRF + L V +++ L P E Sbjct: 350 LRAFFRRFRLDPLPFPRVLAQVTLRPEGGLPARPRE 385 >4Z5Q-A nrPDB Length = 423 Score = 142 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 66/456 (14%), Positives = 148/456 (32%), Gaps = 69/456 (15%) Query: 34 LFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVY--GEFMRVWI-S 90 L+ + E + P P G L Y +++ G+ +RV + Sbjct: 19 LYFQSMSTEVETEKPAPVAYPFTGS-----EGL-----ELSQSYAKLFEDGDPIRVQLPF 68 Query: 91 GEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHE--KGIIFNNNPELWKTTRPFF 148 GE ++++ ++ +S ++ + + I+ + P+ R Sbjct: 69 GEPAWLVTRYDDARFVLTDRRFSRHLATQRDEPRMTPRAVPESILTMDPPDH-TRLRTLV 127 Query: 149 MKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPL 208 KA + + E + ++ + V L + + + Sbjct: 128 SKAFTPRRIESKRAWIGELAAGLVADMKAGGAPAELVGSYAL----------AIPVTVIC 177 Query: 209 DESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRIST 268 + + + W + ++ +S DL+ E L+ E+R Sbjct: 178 ELLGVPEDDRTRLRGWCDAALSTGELTD-----EECVQSFMDLQKYFEDLVKERRA---- 228 Query: 269 EEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPN 327 E D + LI A D L + + +LI +T + + + ++ + Sbjct: 229 ----EPRDDLTSALIEARDAHDRLAEPELIGLCISILIGGFETTASEISSFVHVLQQRRE 284 Query: 328 VEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVD--LVMRKALEDDVIDG 385 + + + + + + E +R+ P + R ALED + G Sbjct: 285 LWTRLCADPEA-----------------IPAAVEELLRFVPFAANGISPRYALEDMTVGG 327 Query: 386 YPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAM 444 V++G +I++ ++R F +E ++ FG G C G ++A Sbjct: 328 VLVREGEPVIVDTSAVNRDGLVFDNADEVVIDRADNR-----HMVFGHGAHHCLGAHLAR 382 Query: 445 VMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480 V ++ L L+ L G ++ D+ + Sbjct: 383 VELQEALKALVEGMPGLRLSG----DVEWKADMIIR 414 >5Z9I-A nrPDB Length = 398 Score = 140 bits (352), Expect = 2e-33, Method: Composition-based stats. Identities = 62/407 (15%), Positives = 129/407 (31%), Gaps = 38/407 (9%) Query: 76 YYNRVYGEFMRVWISGEETL--IISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGII 133 ++ R V E L + S + +SS ++ +G Sbjct: 16 FWMRGKRPDKIVDYDEELQLWNVYGYPESAAILSNPKVFSSDTMRLDPIKLDEAIVEGDF 75 Query: 134 FNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRR 193 + +P + R A + + +M + + LD +E D++ Sbjct: 76 AHTDPPKHRRLRGLVDHAFTPSLVAKMESRVHGIIHELLDGVE----GKSQFDLVAEF-- 129 Query: 194 VMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKD 253 + L L + D + + F W ++ F+ + E+ + + Sbjct: 130 -----AAPLPLIMISDLLGVPESDRALFRQWMDKMLDGSEKFESPETVLEQEEELHKELE 184 Query: 254 AIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAAPDTMS 312 + + R + K D ++L+ AE G L ++ +L+ T + Sbjct: 185 LLWEMRDYWHERAAESRK-RPREDLISQLVHAEVDGQKLNDSQISNIANRLLVNGHLTTA 243 Query: 313 VSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDL 372 + + + + + + + ++ + ESMRY + Sbjct: 244 MLIANTMLCLDAFSDQDARV-----------------RADRSLVPALLEESMRYMSPICG 286 Query: 373 VMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQPFG 431 V R + + G + K +++ G +R E F KP+ F FG Sbjct: 287 VGRATNSEVEVAGTVIPKDQLLLVWTGAANRDERQFEKPDVFDAGRS-----PNAHLGFG 341 Query: 432 FGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLS 478 G C G+ +A + KA + LL R + ++ D S Sbjct: 342 RGIHFCLGRQLARMESKAAVEILLDRLPTLRADPANPPTFLQVVDAS 388 >5L1U-A nrPDB Length = 401 Score = 138 bits (348), Expect = 5e-33, Method: Composition-based stats. Identities = 64/397 (16%), Positives = 123/397 (30%), Gaps = 58/397 (14%) Query: 79 RVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNN- 137 + G RV +GE+ ++++ + ++ + + Sbjct: 28 QKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQPSAKSAARAFMVALAAGD 87 Query: 138 -----PELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLR 192 P R + S L M T + LD+L VL+ Sbjct: 88 DHETEPARHAQMRSLLIPRFSTRRLRLMKTRIEHHVDELLDQLAASAPPVDLHRVLSFR- 146 Query: 193 RVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLK 252 L + D + + + F W +++S + Sbjct: 147 ---------LPTMVVCDLLGVPLADRERFGQWA---------------RGTFDQSDNEHS 182 Query: 253 DAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMS 312 + + + +++E D +ELI AEK G L+ ++ +L+ +T Sbjct: 183 ANTFQQVVDYMLELVARKRVEPGDDILSELI-AEKDGALSDADIAHLGNAVLLFGYETTI 241 Query: 313 VSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQ----P 368 V + L+ ++P + ++ + + E +R Sbjct: 242 VRIDLGTLLLLRNPVQRAQLAEDPG-----------------LAPAAVEEILRLGVGGKG 284 Query: 369 VVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMH-RLEFFPKPNEFTLENFAKNVPYRYF 427 L+ R A D + ++ G ++L IG + FP F L V R Sbjct: 285 SNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPDGGLFDLTR----VRPRSH 340 Query: 428 QPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQ 464 FG G R C G+ +A + + A+ L RR L Sbjct: 341 LAFGHGARHCIGRTLARIELTAVFERLFRRLPDLRLA 377 >2RFC-A nrPDB Length = 343 Score = 138 bits (347), Expect = 6e-33, Method: Composition-based stats. Identities = 63/368 (17%), Positives = 127/368 (34%), Gaps = 70/368 (19%) Query: 97 ISKSSSMFHIMKHNH-YSSRFGSKLGLQCIGMHEKGIIF--NNNPELWKTTRPFFMKALS 153 + K S + H++ ++ +SS G++ + GI F +NPE K R Sbjct: 15 VYKYSDVKHVLMNDKIFSSNPGNRYS------NAGGISFITMDNPEH-KEFRDISAPYFL 67 Query: 154 GPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAI 213 + E+ + ++ D + +R+P++ + Sbjct: 68 PSKINDYKDFIEETSNDLIKNIDNK------------------DIISEYAVRLPVNIISK 109 Query: 214 VVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLE 273 ++ I D+ W + + + + + I + Sbjct: 110 ILGI-----------PDSDMPLFKLWSDYIIGNKRDENFNYVNNRMVSRLLEIFKSDSHG 158 Query: 274 ECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAII 333 A + K LT + + I+ ++I +T + + M+ +I ++P++ + Sbjct: 159 IINVLAGSSL---KNRKLTMDEKIKYIMLLIIGGNETTTNLIGNMIRVIDENPDIID--- 212 Query: 334 KEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVM-RKALEDDVIDGYPVKKGT 392 LK F+ E++RY + + R A ED I+ +KKG Sbjct: 213 -----------------DALKNRSGFVEETLRYYSPIQFLPHRFAAEDSYINNKKIKKGD 255 Query: 393 NIILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAIL 451 +I+ +G +R E FF +P+ F + FG G C G +A + L Sbjct: 256 QVIVYLGSANRDETFFDEPDLFKIGRREM------HLAFGIGIHMCLGAPLARLEASIAL 309 Query: 452 VTLLRRFH 459 +L F Sbjct: 310 NDILNHFK 317 >2FR7-A nrPDB Length = 412 Score = 138 bits (347), Expect = 7e-33, Method: Composition-based stats. Identities = 52/351 (14%), Positives = 117/351 (33%), Gaps = 48/351 (13%) Query: 131 GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 190 +I +P TR K LS + R+ A + +++E+ G +D + Sbjct: 97 SLILEADPPAHTRTRAVLSKVLSPATMKRLRDGFAAAADA---KIDELLARGGNIDAIAD 153 Query: 191 LRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKD 250 L + + + + LL + F + +S + Sbjct: 154 LAEAYPLSVFPDAMGLKQEGRE-------------NLLPYAGLVFNAFGPPNELRQSAIE 200 Query: 251 LKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDT 310 + +AE+ +R + F + G++T E + +L A DT Sbjct: 201 RSAPHQAYVAEQCQRPNLAPGG-----FGACIHAFSDTGEITPEEAPLLVRSLLSAGLDT 255 Query: 311 MSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVV 370 + ++ +A+ P+ + + N E++R++ V Sbjct: 256 TVNGIAAAVYCLARFPDEFARL-----------------RADPSLARNAFEEAVRFESPV 298 Query: 371 DLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYFQP 429 R D + G + +G +++ +G +R + P+ + + Sbjct: 299 QTFFRTTTRDVELAGATIGEGEKVLMFLGSANRDPRRWDDPDRYDITRKTSG-----HVG 353 Query: 430 FGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480 FG G C G+ +A + + +L L R+ + G +++ + +L Sbjct: 354 FGSGVHMCVGQLVARLEGEVVLAALARKVAAIEIAG----PLKRRFNNTLR 400 >1F4U-A nrPDB Length = 368 Score = 137 bits (346), Expect = 7e-33, Method: Composition-based stats. Identities = 58/336 (17%), Positives = 118/336 (35%), Gaps = 60/336 (17%) Query: 137 NPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVML 196 +P L R S L + T E+ ++ LD ++ + D++ L Sbjct: 72 DPPLHDELRSMSADIFSPQKLQTLETFIRETTRSLLDSIDPRED-----DIVKKL----- 121 Query: 197 DTSNTLFLRIPLDESAIVVKIQGYFDAWQALLI-KPDIFFKISWLYKKYEKSVKDLKDAI 255 + L + + + ++ + F W L+ + +I L KKY + + +KD + Sbjct: 122 --AVPLPIIVISKILGLPIEDKEKFKEWSDLVAFRLGKPGEIFELGKKYLELIGYVKDHL 179 Query: 256 EVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSL 315 TE++ +L+ I+ +LIA +T + + Sbjct: 180 NS---------------------GTEVVSRVVNSNLSDIEKLGYIILLLIAGNETTTNLI 218 Query: 316 FFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMR 375 + + N+ + I +E ++ I E++RY P V +R Sbjct: 219 SNSVIDFTRF-NLWQRIREENL-----------------YLKA-IEEALRYSPPVMRTVR 259 Query: 376 KALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENFAKNVPYRYFQPFGFGP 434 K E + +++G + + I +R E F +F + FG G Sbjct: 260 KTKERVKLGDQTIEEGEYVRVWIASANRDEEVFHDGEKFIPDRNPNP-----HLSFGSGI 314 Query: 435 RGCAGKYIAMVMMKAILVTLLRRFH-VKTLQGQCVE 469 C G +A + + + +RF ++ L + V Sbjct: 315 HLCLGAPLARLEARIAIEEFSKRFRHIEILDTEKVP 350 >5YHJ-A nrPDB Length = 413 Score = 137 bits (345), Expect = 1e-32, Method: Composition-based stats. Identities = 67/424 (15%), Positives = 147/424 (34%), Gaps = 56/424 (13%) Query: 84 FMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKT 143 + GE + + + N ++ + + L E G+ + E T Sbjct: 36 IFESRLLGERVICLGGEEAAEVFYDANKFTRQDAAPKRLLKTLFGEGGVQTLDGSE--HT 93 Query: 144 TRP-FFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTL 202 R FM ++ + R++ + EE+ V+ D + + Sbjct: 94 HRKQMFMSLMTKENIDRLLRLTYREWNQIERMGEEI---------------VLYDIAQEV 138 Query: 203 FLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEK 262 ++ + S + + + + + + + + Y + K+ + I ++ E Sbjct: 139 LMKAVCEWSGVPLAKEEVGKRTEEMRLLFESGTSLGPTYLQGRKARSSAEVWIRQMVKEV 198 Query: 263 RRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLI 322 R S E ++ G+L E V +E+L T+++S++ + ++ Sbjct: 199 R---SNRLLPNEHTALYEFSWHRDESGELLPEEVV--AVEVLNILRPTVAISVYVLFTVL 253 Query: 323 AKH--PNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALED 380 A H P+V+E + + + F+ E R+ P + + D Sbjct: 254 ALHQFPDVKEQVERGEVSKTE-----------------FVQEVRRFYPFFPVAAARVKTD 296 Query: 381 DVIDGYPVKKGTNIILNIG-RMHRLEFFPKPNEFTLENFA--KNVPYRYFQPFGFGP--- 434 DGY +GT +L++ H + + +P+ F F K P+ F P G G Sbjct: 297 FEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSRFKDWKESPFN-FIPQGGGDVDF 355 Query: 435 -RGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFT 493 CAG+++ + ++ ++ + + V + P K+ L + Sbjct: 356 GHRCAGEHVTIAILAQVIELFTKEY------AYTVPPQDLSYSFVDMPSLPKSKLRLTHL 409 Query: 494 PRNS 497 RN Sbjct: 410 TRNQ 413 >6HQW-A nrPDB Length = 445 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 48/316 (15%), Positives = 108/316 (34%), Gaps = 43/316 (13%) Query: 144 TRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLF 203 R A + +V M + LD L E D + Sbjct: 140 QRRTVAPAFTPAKMVEMEAEIRRRTASVLDSL--PWGER-------------FDWVD--- 181 Query: 204 LRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKR 263 ++ ++ + ++ I F W + + + + D + +A Sbjct: 182 -KVSIELTTGMLAILFGF-PWADRRLLTFWSDWAGDVELTLARELADTRFGFLGEMAHYF 239 Query: 264 RRISTEE-KLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLI 322 +R+ + D + +I +E ++ + ++ +++ DT ++ ++ + Sbjct: 240 QRLWGARMQAPPSGDLISMMIHSEAMNHMSPQEFMGNLVLLIVGGNDTTRNTMSGIVHAL 299 Query: 323 AKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDV 382 K P+ E + ++ ++ N + E +RY + + R A D Sbjct: 300 DKFPDQRELLERDAS-----------------LIPNAVQECIRYVTPLAHMRRTATADTE 342 Query: 383 IDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKY 441 + G +K G +IL +R E F P++ ++ R FG G C G Sbjct: 343 LFGNQIKAGEKVILWYISANRDETVFENPDKLMVDRPN----ARRHLSFGHGIHRCVGAR 398 Query: 442 IAMVMMKAILVTLLRR 457 +A + ++ +L + R Sbjct: 399 LAELQLRILLEEMHER 414 >5DQN-A nrPDB Length = 426 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 54/384 (14%), Positives = 124/384 (32%), Gaps = 60/384 (15%) Query: 96 IISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHE---------KGIIFNNNPELWKTTRP 146 +++K + + + + + + + + ++ N + R Sbjct: 55 LVTKHADVKEVSRRSDVFGSSPDGAI--PVYPQDMTREAVDLQRAVLLNMDAPQHTRLRK 112 Query: 147 FFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRI 206 + + + R+ + L++ ++ + G D + S L L+ Sbjct: 113 IISRGFTPRAIGRLE----DELRSRAQKIAQTAAAQGAGDFVEQ-------VSCELPLQA 161 Query: 207 PLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRI 266 + + + W + + Y + ++ + + ++ Sbjct: 162 IAELLGVPQDDRDKLFRWSNEMTAGE-----DPEYADVDPAMSSFELISYAM------KM 210 Query: 267 STEEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKH 325 + E + D T+LI A+ G+ L+ + ++ + +A +T S+ + A++ Sbjct: 211 AEERAVNPTEDIVTKLIEADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITHGMIAFAQN 270 Query: 326 PNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDG 385 P+ E KE R D E +R+ V R ALED + G Sbjct: 271 PDQWELYKKE-------RPETAAD------------EIVRWATPVSAFQRTALEDVELGG 311 Query: 386 YPVKKGTNIILNIGRMH-RLEFFPKPNEFTLENFAKNVPYRYFQPFGF-GPRGCAGKYIA 443 +KKG ++++ + E F P+ F + FG G C G +A Sbjct: 312 VQIKKGQRVVMSYRSANFDEEVFEDPHTFNILRSPNP-----HVGFGGTGAHYCIGANLA 366 Query: 444 MVMMKAILVTLLRRFHVKTLQGQC 467 + + I + G Sbjct: 367 RMTINLIFNAIADNMPDLKPIGAP 390 >5DE9-A nrPDB Length = 410 Score = 137 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 57/408 (13%), Positives = 125/408 (30%), Gaps = 58/408 (14%) Query: 82 GEFMRVWI--SGEETLIISKSSSMFHIMKHNHYSSRFGSKLGL----QCIGMHEKGIIFN 135 G R+ + ++++ + + + + + F Sbjct: 37 GPVTRISLPNGEGWAWLVTRHDDVRLVTNDPRFGREAVMDRQVTRLAPHFRPARGAVGFL 96 Query: 136 NNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVM 195 + P+ R A + G+ R+ L +D + + + + Sbjct: 97 DPPDH-TRLRRSVAAAFTARGVERVRERSRGMLDELVDAMLRAGPPADLTEAV------- 148 Query: 196 LDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAI 255 + + + + + + W L++ ++S E++ ++ Sbjct: 149 ---LSPFPIAVICELMGVPATDRHSMHTWTQLILSSSHGAEVS------ERAKNEMNAYF 199 Query: 256 EVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSL 315 LI + D + L A R ++T + + I + ++ + Sbjct: 200 SDLIGLR--------SDSAGEDVTSLLGAAVGRDEITLSEAVGLAVLLQIGG-EAVTNNS 250 Query: 316 FFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQP--VVDLV 373 M L+ P + E + E ++ I E +R+ P + Sbjct: 251 GQMFHLLLSRPELAERLRSE-----------------PEIRPRAIDELLRWIPHRNAVGL 293 Query: 374 MRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYFQPFGF 432 R ALED I G ++ G + ++ +R E FP P+ E FGF Sbjct: 294 SRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFERSPNP-----HVSFGF 348 Query: 433 GPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480 GP C G +A + + ++ +L R L E + + Sbjct: 349 GPHYCPGGMLARLESELLVDAVLDRVPGLKLAVAP-EDVPFKKGALIR 395 >5HH3-A nrPDB Length = 397 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 61/393 (15%), Positives = 126/393 (32%), Gaps = 53/393 (13%) Query: 90 SGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFM 149 G + + + ++ + +S+R G+ G + +P R Sbjct: 50 GGRTAWLATGYDEIRQVLSSDDFSARLLYGGT--AAGITWPGFLTQYDPPEHTRLRRMVA 107 Query: 150 KALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLD 209 A + + + ++ LD +E + G VD + + T+ FL IP D Sbjct: 108 PAFAVRRMQKFQPQVERVVQDSLDAIEAL---GGPVDFVPRFGWSVATTATCDFLGIPRD 164 Query: 210 ESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTE 269 + A + + + K+ + + + A RR Sbjct: 165 DQADLARSLH--------------ASRTERSGKRRTAAGNKFMTYMNKMTARTRR----- 205 Query: 270 EKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVE 329 + D +++ E ++T + ++ A D ++ L +L+A P Sbjct: 206 ----DPGDDMFGVVVREYGDEITDAELTGVAAFVMGAGADQVARFLAAGAWLMADDPEQF 261 Query: 330 EAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLV-MRKALEDDVIDGYPV 388 + ++ TV + E +RY + R A +D I + + Sbjct: 262 ALLREKPDTVPDW-----------------LDEVIRYLTTDEKTHPRVATDDVRIGDHLI 304 Query: 389 KKGTNIILNIGRMHRLEFFPKP-NEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMM 447 K G + ++ +R FP+P + F + FG G C G+ +A ++ Sbjct: 305 KAGDTVTCSLLAANR-RNFPRPEDRFDITRVRPE-----HLAFGHGIHHCLGRSLAELVF 358 Query: 448 KAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480 + + L RF L E + Sbjct: 359 RTAIPALAHRFPTLRLAEPHREIRLGPPPFDVE 391 >6CVC-A nrPDB Length = 433 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 54/355 (15%), Positives = 122/355 (34%), Gaps = 43/355 (12%) Query: 131 GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 190 +I ++P + R +A + + R+ E + + E + G D+++ Sbjct: 113 SMIVLDDPRH-QRLRSIVSRAFTPKVVARIEASVRERAHRLVAAMIE-NHPDGQADLVSE 170 Query: 191 LRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKD 250 L L L+I D I + W +++ F L +++ ++ Sbjct: 171 LAG-------PLPLQIICDMMGIPEEDHEQIFHWTNVILG----FGDPDLTTDFDEFLQ- 218 Query: 251 LKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAAPD 309 + + I ++ + ++ D T L+ AE G+ L+ + + +++A + Sbjct: 219 ----VSMAIGGYATALADDRRVNHHGDLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNE 274 Query: 310 TMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPV 369 T ++ + ++++P+ + + + E +R+ Sbjct: 275 TTRNAISHGMLALSRYPDERAKWWSDFDG----------------LAATAVEEIVRWASP 318 Query: 370 VDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENFAKNVPYRYFQ 428 V + R +D + G + G + L +R E F P F + Sbjct: 319 VVYMRRTLSQDVDLRGTKMAAGDKVTLWYCSANRDEEKFADPWTFDVTRNPNPQ-----V 373 Query: 429 PF-GFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESI-QKIHDLSLHP 481 F G G C G +A ++ + L R+ + + Q IH + P Sbjct: 374 GFGGGGAHFCLGANLARREIRVVFDELRRQMPDVVATEEPARLLSQFIHGIKRLP 428 >6DCD-A nrPDB Length = 424 Score = 133 bits (334), Expect = 2e-31, Method: Composition-based stats. Identities = 57/334 (17%), Positives = 108/334 (32%), Gaps = 46/334 (13%) Query: 127 MHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVD 186 + ++ + PE R + L+ L + LD +G + Sbjct: 93 PMYEHMVTMDPPEH-SRARSILSRLLTPSRLKQNEEFMWRLADRQLDEF----LGAGECE 147 Query: 187 VLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEK 246 ++ + L +P D+ + G + + + Sbjct: 148 FISEYAKPFATLVIADLLGVPEDDRKDFRVVLGADRMGRVGALDHESVGVNP-------- 199 Query: 247 SVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRE--NVNQCILEML 304 ++ L D I ++RR + D T L A T E +V + + Sbjct: 200 -LQWLDDKFSAYIEDRRR--------QPRNDVLTALATATYPDGSTPEVIDVVRSATFLF 250 Query: 305 IAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESM 364 A +T + L + ++ P+++ + + ++ NFI ES+ Sbjct: 251 AAGQETTAKLLTAAMRVLGDRPDIQRRLRE-----------------NRSLIPNFIEESL 293 Query: 365 RYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVP 423 R V R A + + G + GT +++ G +R F P+EF L+ Sbjct: 294 RMDSPVKSDSRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDRPN---- 349 Query: 424 YRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRR 457 R F G C G +A V + L +L R Sbjct: 350 VREHMAFARGVHSCPGGPLARVEGRVSLERILDR 383 >2UUQ-A nrPDB Length = 414 Score = 132 bits (332), Expect = 4e-31, Method: Composition-based stats. Identities = 57/372 (15%), Positives = 120/372 (32%), Gaps = 46/372 (12%) Query: 91 GEETLIISKSSSMFHIMKHNHYS---SRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPF 147 + ++ + H +S + L+ IG+H+ + +P + R Sbjct: 51 YDYYVLSRHADVWSAARDHQTFSSAQGLTVNYGELEMIGLHDTPPMVMQDPPVHTEFRKL 110 Query: 148 FMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIP 207 + + + + K ++RLE++ G D++T L + L + Sbjct: 111 VSRGFTPRQVETVEPTVR---KFVVERLEKLRANGGG-DIVTELFK-------PLPSMVV 159 Query: 208 LDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRIS 267 + + FD W ++ + + +V + LI +R Sbjct: 160 AHYLGVPEEDWTQFDGWTQAIVAANAVDGATT---GALDAVGSMMAYFTGLIERRR---- 212 Query: 268 TEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPN 327 TE + + A+ T + M+ DT++ L + L+ + P+ Sbjct: 213 TEPADDAISHLVAAGVGADGDTAGTLS-ILAFTFTMVTGGNDTVTGMLGGSMPLLHRRPD 271 Query: 328 VEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYP 387 ++ + + + + + E +R V + R D I Sbjct: 272 QRRLLLDDPEG-----------------IPDAVEELLRLTSPVQGLARTTTRDVTIGDTT 314 Query: 388 VKKGTNIILNIGRMHRLE--FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMV 445 + G ++L G +R E + P E + +N+ F G C G A + Sbjct: 315 IPAGRRVLLLYGSANRDERQYGPDAAELDVTRCPRNI-----LTFSHGAHHCLGAAAARM 369 Query: 446 MMKAILVTLLRR 457 + L LL R Sbjct: 370 QCRVALTELLAR 381 >5HDI-A nrPDB Length = 404 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 53/345 (15%), Positives = 124/345 (35%), Gaps = 58/345 (16%) Query: 122 LQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNE 181 + +G + ++P R ++ L+ + + V + DRL + Sbjct: 80 MDPLGGPTHVLATADDPAH-AVHRKLVLRHLA----AKRIRVMEQFTVQAADRLWVDGMQ 134 Query: 182 SGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVK--------IQGYFDAWQALLIKPDI 233 G ++ + + + + +P + A +VK ++G + Q + + Sbjct: 135 DGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGVAL 194 Query: 234 FFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTR 293 +++++++++ D +D + EL A G+L Sbjct: 195 MELSGYIFEQFDRAAADPRD-----------------------NLLGELATACASGELDT 231 Query: 294 ENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKL 353 ++ + A ++ + L ++++A P++++ + Sbjct: 232 LTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQV-----------------RANP 274 Query: 354 KVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEF-FPKPNE 412 +++ FI E++RY+P R +DG + ++++L G +R F P E Sbjct: 275 ELLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGE 334 Query: 413 FTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRR 457 F L+ FG G C G +A + + +L LL R Sbjct: 335 FRLDRAGGKG----HISFGKGAHFCVGAALARLEARIVLRLLLDR 375 >5HIW-A nrPDB Length = 398 Score = 129 bits (324), Expect = 3e-30, Method: Composition-based stats. Identities = 58/332 (17%), Positives = 114/332 (34%), Gaps = 42/332 (12%) Query: 130 KGIIFNNNPELWKTTRPFFMKALSGPGLVRMVT-VCAESLKTHLDRLEEVTNESGYVDVL 188 KG + E R F LS + R + ++RL V Sbjct: 69 KGALVTLGGEAHTRMRRLFNAVLSPRVISRYEEATVTPVARRVVERL-----------VR 117 Query: 189 TLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSV 248 + D + ++ + + + + DA +I+ + + + + + Sbjct: 118 KERAELFDDFAISMPMGVTSALFGLPEERIAENDALIRKMIRSVVMPQDPVVVAEGRSAH 177 Query: 249 KDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAP 308 ++ + IAE+ ++ L E I+AE G + E +L +++ + Sbjct: 178 AAMEAQLRE-IAEREVAHPSDTLLGE----IARAIVAEGLGGV--EACEGVVLTLILGSY 230 Query: 309 DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQP 368 +T S L +L + HP+ + Q+ ++ I ES R+ Sbjct: 231 ETTSWMLANLLVALLAHPDAMNQL-----------------RQQPSLLPQAIEESTRWCS 273 Query: 369 VVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMH-RLEFFPKPNEFTLENFAKNVPYRYF 427 ++R + I G + GT + L++ H E +P+P F + Sbjct: 274 SAAGIVRFVEREATIGGETLAAGTILYLSLIARHYDEEIYPRPETFDIHRR-----PVGM 328 Query: 428 QPFGFGPRGCAGKYIAMVMMKAILVTLLRRFH 459 FG G C G +A + + + LL RF Sbjct: 329 LNFGGGLHYCVGAPLARMEARVGVSLLLERFP 360 >5EX8-A nrPDB Length = 424 Score = 128 bits (322), Expect = 4e-30, Method: Composition-based stats. Identities = 64/391 (16%), Positives = 129/391 (32%), Gaps = 51/391 (13%) Query: 91 GEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMK 150 G + + + ++ + +S+R G+ G + +P R + Sbjct: 78 GRTAWLATGIDEVRQVLGSDKFSARLLYGGT--AAGITWPGFLTQYDPPEHTRLRRMVVP 135 Query: 151 ALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDE 210 A S + + + ++ LD +E + G VD + + + FL IP D+ Sbjct: 136 AFSHRRMQKFRPRVEQIVQDSLDTIESL---GGPVDFVPHFGWAIATPATCDFLGIPRDD 192 Query: 211 SAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEE 270 A + +I L + ++S K A + ++ ++ Sbjct: 193 QADLARI---------------------LLASRTDRSDKRRTAAGNKFMTYMKQHVAQSR 231 Query: 271 KLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEE 330 + D ++ E +T + ++ AA D ++ L +L+ + P Sbjct: 232 RGSG--DDLFGIVGRENGDAITDAELTGVAAFVMGAAADQVARLLAAGAWLMVEQPAQFA 289 Query: 331 AIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLV-MRKALEDDVIDGYPVK 389 + ++ +TV + E+MRY + R A +D I VK Sbjct: 290 LLREKPETVPEW-----------------LDETMRYLTTDEKTHPRVATQDVRIGNQLVK 332 Query: 390 KGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKA 449 G + ++ +R + +EF + FG G C G+ +A +M K Sbjct: 333 AGDTVTCSLLAANRPNYPSAEDEFDITREKAE-----HLAFGHGIHHCLGRAMAELMFKV 387 Query: 450 ILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480 + L RF L E + Sbjct: 388 SIPALAHRFPTLRLADPQREITLGPPPFDVE 418 >5H1Z-A nrPDB Length = 407 Score = 128 bits (322), Expect = 5e-30, Method: Composition-based stats. Identities = 48/319 (15%), Positives = 107/319 (33%), Gaps = 49/319 (15%) Query: 144 TRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEE----VTNESGYVDVLTLLRRVMLDTS 199 R A + +VRM LD LE ++ V++ T + ++ D Sbjct: 102 QRRTVAPAFTPSEMVRMSDNIRMRTAEVLDSLEWNTPFDWVDTVSVELTTQMLAILFDF- 160 Query: 200 NTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLI 259 P +E + ++ W K L + + + + + L Sbjct: 161 -------PWEERRKLT----FWSDW----AGDIELVKNEELRLERLRHMYECGGYFQNLW 205 Query: 260 AEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFML 319 K + T D + +I ++ ++ + ++ +++ DT ++ + Sbjct: 206 NAKIGKPPTP-------DLISMMIHSDAMAEMDQMEFLGNLILLIVGGNDTTRNTMSAVA 258 Query: 320 FLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALE 379 + + P+ + ++ N + E +R+Q + + R A Sbjct: 259 YGLDLFPDQRAKLE-----------------ADPSMIPNTVQEIIRWQTPLAHMRRTATV 301 Query: 380 DDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCA 438 D ++G +K G + L +R E F + ++ R FG G C Sbjct: 302 DSELEGQQIKAGDKLALWYISANRDESVFENADRIIVDRPN----ARRHLAFGHGIHRCV 357 Query: 439 GKYIAMVMMKAILVTLLRR 457 G +A + + +L + +R Sbjct: 358 GARLAELQIAVLLEEMAKR 376 >3OO3-A nrPDB Length = 384 Score = 128 bits (321), Expect = 6e-30, Method: Composition-based stats. Identities = 63/399 (15%), Positives = 135/399 (33%), Gaps = 62/399 (15%) Query: 89 ISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQ--CIGMHEKGIIFNNNPELWKTTRP 146 + G + +++ + I+ + RF S + GI+ +P R Sbjct: 36 MDGRKQWLVTGHDEVRAILADHE---RFSSMRPVDDEADRALLPGILQAYDPPDHTRLRR 92 Query: 147 FFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRI 206 A S + R+ E ++ LD E V VD + + FL + Sbjct: 93 TVAPAYSARRMERLRPRIEEIVEECLDDFESV---GAPVDFVRHAAWPIPAYIACEFLGV 149 Query: 207 PLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRI 266 P D+ A + ++ + + E + + + I +R+ Sbjct: 150 PRDDQAELSRM----------------------IRESRESRLPRQRTLSGLGIVNYTKRL 187 Query: 267 STEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHP 326 ++ ++ + D +I+ E +++ E + LI A + M+ L + L+ HP Sbjct: 188 TSGKRRDPG-DGMIGVIVREHGAEISDEELAGLAEGNLIMAAEQMAAQLAVAVLLLVTHP 246 Query: 327 NVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDL-VMRKALEDDVIDG 385 + + + K +++++ E +R+ +V+ R AL D + G Sbjct: 247 DQMALLRE-----------------KPELIDSATEEVLRHASIVEAPAPRVALADVRMAG 289 Query: 386 YPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMV 445 + G + ++ +R + F + FG G C G +A + Sbjct: 290 RDIHAGDVLTCSMLATNRAP----GDRFDITREKAT-----HMAFGHGIHHCIGAPLARL 340 Query: 446 MMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDET 484 ++ L ++ RF L E ++ P Sbjct: 341 QLRVALPAVVGRFPSLRLA-VPEEDLRFKPG---RPAPF 375 >1UE8-A nrPDB Length = 367 Score = 125 bits (313), Expect = 6e-29, Method: Composition-based stats. Identities = 55/335 (16%), Positives = 106/335 (31%), Gaps = 40/335 (11%) Query: 143 TTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTL 202 + F L+G + + R +T++ D L L + SN Sbjct: 35 DHKRFS-SNLTGYNDKLEMLRSGKVFFDIPTRYTMLTSDPPLHDELRNLTADAFNPSNLP 93 Query: 203 FLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYE-KSVKDLKDAIEVLIAE 261 + ++ ++ FD ++ I I L + K VKD D + + + Sbjct: 94 VDFVREVTVKLLSELDEEFDVIESFAIPLPILVISKMLGINPDVKKVKDWSDLVALRLGR 153 Query: 262 KRRRISTEEKLEECMDF------------ATELILAEKRGDLTRENVNQCILEMLIAAPD 309 S K E + F +L +L+ + ++IA + Sbjct: 154 ADEIFSIGRKYLELISFSKKELDSRKGKEIVDLTGKIANSNLSELEKEGYFILLMIAGNE 213 Query: 310 TMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPV 369 T + + + + V + +K + E++R+ P Sbjct: 214 TTTNLIGNAIEDFT--------LYNSWDYVREKGALK------------AVEEALRFSPP 253 Query: 370 VDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQ 428 V +R E I + +G + + I +R E F P+ F + Sbjct: 254 VMRTIRVTKEKVKIRDQVIDEGELVRVWIASANRDEEVFKDPDSFIPDRTPNP-----HL 308 Query: 429 PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTL 463 FG G C G +A + + L ++F VK + Sbjct: 309 SFGSGIHLCLGAPLARLEARIALEEFAKKFRVKEI 343 >3IVY-A nrPDB Length = 433 Score = 124 bits (312), Expect = 6e-29, Method: Composition-based stats. Identities = 63/372 (16%), Positives = 125/372 (33%), Gaps = 52/372 (13%) Query: 96 IISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGP 155 I+K + + I +H+ S + + I + I + + F M + P Sbjct: 72 AITKLNDVKEISRHSDVFSSYEN----GVIPRFKNDIAREDI-----EVQRFVMLNMDAP 122 Query: 156 GLVRMVTVCAE-----SLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDE 210 R+ + + ++ D L+E + + S L L+ Sbjct: 123 HHTRLRKIISRGFTPRAVGRLHDELQERAQKIAAEAAAAGSGDFVEQVSCELPLQAIAGL 182 Query: 211 SAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEE 270 + + +G W + + E + D K + LI +++ E+ Sbjct: 183 LGVPQEDRGKLFHWSNEMTGN----------EDPEYAHIDPKASSAELI-GYAMKMAEEK 231 Query: 271 KLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVE 329 D T+LI A+ G+ L+ + ++ + +A +T S+ + A+HP+ Sbjct: 232 AKNPADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITQGMMAFAEHPDQW 291 Query: 330 EAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVK 389 E + K+++ E E +R+ V R AL D + G +K Sbjct: 292 E-LYKKVRP------------------ETAADEIVRWATPVTAFQRTALRDYELSGVQIK 332 Query: 390 KGTNIILNIGRMH-RLEFFPKPNEFTLENFAKNVPYRYFQPFGF-GPRGCAGKYIAMVMM 447 KG +++ + E F P F + FG G C G +A + + Sbjct: 333 KGQRVVMFYRSANFDEEVFQDPFTFNILRNPNP-----HVGFGGTGAHYCIGANLARMTI 387 Query: 448 KAILVTLLRRFH 459 I + Sbjct: 388 NLIFNAVADHMP 399 >2X9P-A nrPDB Length = 404 Score = 124 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 66/396 (16%), Positives = 121/396 (30%), Gaps = 67/396 (16%) Query: 82 GEFMRVWI-SGEETLIISKSSSMFHIMKHNHYSSRF----GSKLGLQCIGMHEKGIIFNN 136 G RV +G+E ++++ + + + H+ R S + I + Sbjct: 39 GPIHRVRTPAGDEAWLVTRHAELKQ-LLHDERIGRTHPDPPSAAQYVRSPFLDLLISDAD 97 Query: 137 NPELWKTT---RPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRR 193 + R S ++ M E+ T LD D+ L Sbjct: 98 AESGRRQHAETRRLLTPLFSARRVLEMQPKVEEAADTLLDAFIAQGPPG---DLHGELTV 154 Query: 194 VMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKD 253 T + +P A + + ++ DL Sbjct: 155 PFALTVLCEVIGVPPQRRAELTTLLAGIAKLDDREGAV--------------RAQDDLFG 200 Query: 254 AIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSV 313 + L+ KR E D + L G+LT + V + +L A D+++ Sbjct: 201 YVAGLVEHKRA--------EPGPDIISRL----NDGELTEDRVAHLAMGLLFAGLDSVAS 248 Query: 314 SLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRY----QPV 369 + + L+A HP+ A + + VM + E +R V Sbjct: 249 IMDNGVVLLAAHPDQRAAALADPD-----------------VMARAVEEVLRTARAGGSV 291 Query: 370 VDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQ 428 + R A ED G ++ G ++ ++G + E F P EF Sbjct: 292 LP--PRYASEDMEFGGVTIRAGDLVLFDLGLPNFDERAFTGPEEFDAARTPNP-----HL 344 Query: 429 PFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQ 464 FG G C G +A + ++ + L R + Sbjct: 345 TFGHGIWHCIGAPLARLELRTMFTKLFTRLPELRPE 380 >4PWV-A nrPDB Length = 446 Score = 123 bits (309), Expect = 1e-28, Method: Composition-based stats. Identities = 57/346 (16%), Positives = 115/346 (33%), Gaps = 47/346 (13%) Query: 125 IGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGY 184 K + + + R +K+ S L +V + ++ + RL G Sbjct: 111 DSAAGKMLAVTDGAMH-RGLRNVLLKSFSPQALKPIV----DQIRVNTTRLVVDAARRGE 165 Query: 185 VDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKY 244 D + + + + L +P + ++K+ + + D +WL Sbjct: 166 CDFAADVAEQIPLNTISDLLGVPAADREFLLKLNKSALSSED----ADQSATDAWL---- 217 Query: 245 EKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRG-DLTRENVNQCILEM 303 + ++ L+AE+R + D + L + G LT E + + Sbjct: 218 --ARNEILLYFSELVAERRAK--------PTEDVISVLANSMVDGKPLTEEVIVLNCYSL 267 Query: 304 LIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYES 363 ++ +T +S+ + ++P+ E + T +E+ E Sbjct: 268 ILGGDETSRLSMIDSVQTFTQYPDQWELLRDGKVT-----------------LESATEEV 310 Query: 364 MRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENFAKNV 422 +R+ R+A+ D + G + G + L +R E F P F L Sbjct: 311 LRWATPAMHFGRRAVTDMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAFDLNRS---- 366 Query: 423 PYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCV 468 FG+GP C G Y+ + A+L L + G+ Sbjct: 367 -PNKHITFGYGPHFCLGAYLGRAEVHALLDALRTYTTGFEITGEPQ 411 >4DO1-A nrPDB Length = 410 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 45/351 (12%), Positives = 110/351 (31%), Gaps = 49/351 (13%) Query: 131 GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 190 +I +P R K LS + + A + +D L + G +D + Sbjct: 96 SLILEADPPAHTRPRAVLSKVLSPATMKTIRDGFAAAADAKVDEL----LQRGCIDAIAD 151 Query: 191 LRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKD 250 L + + + + ++ G + F + L + + Sbjct: 152 LAEAYPLSVFPDAMGLKQEGREHLLPYAGLV---------FNAFGPPNELRQTAIERSAP 202 Query: 251 LKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDT 310 + + + F + G++T + + +L A DT Sbjct: 203 HQAYVNE---------QCQRPNLAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDT 253 Query: 311 MSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVV 370 + ++ +A+ P + + + N E++R++ V Sbjct: 254 TVNGIGAAVYCLARFPGELQRL-----------------RSDPTLARNAFEEAVRFESPV 296 Query: 371 DLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYFQP 429 R + + G + +G +++ +G +R + P+ + + Sbjct: 297 QTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITRKTSG-----HVG 351 Query: 430 FGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH 480 FG G C G+ +A + + +L L R+ + G +++ + +L Sbjct: 352 FGSGVHMCVGQLVARLEGEVMLSALARKVAAIDIDG----PVKRRFNNTLR 398 >5LIV-A nrPDB Length = 450 Score = 122 bits (306), Expect = 3e-28, Method: Composition-based stats. Identities = 58/364 (15%), Positives = 116/364 (31%), Gaps = 42/364 (11%) Query: 98 SKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGL 157 + Y + G+ G+ E R + + Sbjct: 89 GMPILLRKSHITTAYRDTATFSTRMFQAGILNGGLAAMQGDEH-ARMRRVYNMFFLPRAV 147 Query: 158 VRMVTVCAESL-KTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVK 216 + + + +DRL VD+L D + L R+ + + Sbjct: 148 SQYEERFVRPISEQVVDRLA----GKPRVDLLE-------DFAMELPRRVIGELFGFPAE 196 Query: 217 IQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECM 276 D +++ + + +++ + I ++ E+ R +++ L E Sbjct: 197 KLHETDERVRAMLRGLVRMHDPAAVAESQRAYGETLGLITEVV-ERESRDTSDTLLGE-- 253 Query: 277 DFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEI 336 + AE T E Q +L +++ +T S + + + HP+ + Sbjct: 254 --ILRTLKAEHMD--TIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARV---- 305 Query: 337 QTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNI-I 395 Q ++ I E MR+ P V+R D +D + GT + + Sbjct: 306 -------------RQDPSLLPAAIEEGMRWCPSSFGVLRMVERDVRLDDQALSAGTVVCL 352 Query: 396 LNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLL 455 I + +P P + ++ K +P FG G C G +A + + L LL Sbjct: 353 AGIAGNYDETAYPSPEVYDIDR--KPLPAANV--FGGGAHFCVGAPLARMEARVGLQALL 408 Query: 456 RRFH 459 RF Sbjct: 409 ARFP 412 >6BLD-A nrPDB Length = 419 Score = 122 bits (306), Expect = 4e-28, Method: Composition-based stats. Identities = 52/354 (14%), Positives = 106/354 (29%), Gaps = 38/354 (10%) Query: 133 IFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLR 192 +P R A + + R+ + K +D L +V+ Sbjct: 102 FLAMDPPRHTKLRKLVSAAFTPRQVRRIEDSIKINAKGIVDELRMAGGGVDFVE------ 155 Query: 193 RVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLK 252 + L +R D I + L+ Y + + L Sbjct: 156 ----HCAKELPIRTLSDMVGIPEADRERVAHAADALVS-----WADPRYLNGREPLAVLF 206 Query: 253 DAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAAPDTM 311 + ++ + + ++ E + D + L+ AE GD L +V + + +A DT Sbjct: 207 EN-QMYLHQVAASLAAERRDRPGDDLFSALVNAEVDGDRLADADVAAFFVLLAVAGNDTT 265 Query: 312 SVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVD 371 ++ L + P+ + ++ + T IG + E +R+ V Sbjct: 266 RQTISHGLKALTDFPSQKAWLLADFDTRIG----------------TAVEELVRWATPVM 309 Query: 372 LVMRKALEDDVIDGYPVKKGTNIILNIGRMH-RLEFFPKPNEFTLENFAKNVPYRYFQPF 430 R A D + G ++ G +++ + + F P L Sbjct: 310 TFRRTAAADFELGGQLIRAGEKVVMFYASGNWDEDAFCHPERLDLSRSPNPHVGFGGGG- 368 Query: 431 GFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDET 484 C G ++A ++AI LL + +H + P Sbjct: 369 ---VHFCLGAHLARAQLRAIFGELLVQLPDIQAGDPVYVPGNFVHAIRSMPCTF 419 >3BUJ-A nrPDB Length = 397 Score = 122 bits (305), Expect = 5e-28, Method: Composition-based stats. Identities = 54/317 (17%), Positives = 110/317 (34%), Gaps = 42/317 (13%) Query: 131 GIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTL 190 II + R A S L R+ V A ++ L G +DV+ Sbjct: 77 DIILFQDEPDHGRLRGVVGPAFSPSALRRLEPVIAGTVDDLLR----PALARGAMDVVDE 132 Query: 191 LRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKD 250 L + L LR L + G W + + + ++ ++ + Sbjct: 133 L-------AYPLALRAVLGLLGLPAADWGAVGRWSRDVGRTLDRGASAEDMRRGHAAIAE 185 Query: 251 LKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDT 310 D +E + E D ++ A RG ++R + ++ + +T Sbjct: 186 FADYVER--------ALARRRREGGEDLLALMLDAHDRGLMSRNEIVSTVVTFIFTGHET 237 Query: 311 MSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVV 370 ++ + + + HP+ + + ++ ++ + E +RY P V Sbjct: 238 VASQVGNAVLSLLAHPDQLDLL-----------------RRRPDLLAQAVEECLRYDPSV 280 Query: 371 DLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYFQP 429 R+ D + G +++ +++ G +R + +P++F +E VP Sbjct: 281 QSNTRQLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDFDIER--DPVPS---MS 335 Query: 430 FGFGPRGCAGKYIAMVM 446 FG G R C G Y+A Sbjct: 336 FGAGMRYCLGSYLARTQ 352 >6GII-A nrPDB Length = 479 Score = 121 bits (304), Expect = 5e-28, Method: Composition-based stats. Identities = 69/468 (14%), Positives = 144/468 (30%), Gaps = 52/468 (11%) Query: 43 GTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRV-----YGEFMRVWISGEETLI- 96 G SS+ G + + +M + + R Y + W+ I Sbjct: 53 GQSSVGG-CPVHRLAEDFDPFQDAYMADPAQFVRWAREQVPIFYAPKLNYWVVTRYDTIK 111 Query: 97 -ISKSSSMFH--IMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALS 153 I + F + + + L+ G + N + + R M+ + Sbjct: 112 QIFRDPVTFSPSNVLQSFAQPSAEVRQVLERYGYAFNRTLVNEDEPMHLERRRVLMEPFA 171 Query: 154 GPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAI 213 L + E ++ ++R + G D++ + + T FL + D+ Sbjct: 172 SEHLAEHEPMVRELVRRAVNRFIDT----GRADLVDQMIWEVPFTVALHFLGVDDDDREK 227 Query: 214 VVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLE 273 + A+ + F + S + + EK RR + Sbjct: 228 M--------RRFAIAHTVNAFGRPSPEEQLAVAETVGQFWQFCGEVLEKMRRTADGPGWM 279 Query: 274 ECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAII 333 +L +T ++ + +++AA +T + L + +H V I Sbjct: 280 RYSIRQQKL----YPDVVTDSYLHSMMQAIIVAAHETTVFATTNALKTLLEHETVWREI- 334 Query: 334 KEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTN 393 ++ E +RY V R+ + ++G + G N Sbjct: 335 ----------------CADPSLIPAAAEECLRYNGPVAGWRRRTTREVEVEGVRLPVGAN 378 Query: 394 IILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILV 452 I++ + + F P F + + FG+G C G+ + + M+ ++ Sbjct: 379 ILMVVASANHDSAHFDDPEFFDIGRSNAS----EHLNFGYGAHQCLGRNLGRMEMQIMIE 434 Query: 453 TLLRRFHVKTLQGQCVESIQKIHDLSLH-PDETKNMLEMIFTPRNSDR 499 L RR L Q + + H++S P + P D Sbjct: 435 ELSRRLPHMRLAEQRFDYL---HNVSFRAPRHLWVEWDPAQNPERRDP 479 >5D3U-A nrPDB Length = 427 Score = 121 bits (302), Expect = 9e-28, Method: Composition-based stats. Identities = 57/350 (16%), Positives = 109/350 (31%), Gaps = 44/350 (12%) Query: 124 CIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESG 183 K ++ +P L R + V + + + + Sbjct: 99 IFHRWTKNVVMYTDPPLHDALRRSVRAGFTRAAHQHYDQVLQKVAHDLVASIPA---GAT 155 Query: 184 YVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKK 243 +D + L + L +R + + + G+ ++ K + ++ Sbjct: 156 EIDAVPAL-------AAELPVRSAVHAFGVPEEDLGFLIPRVNTIMTYFSGPKDQPVTQE 208 Query: 244 Y-EKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRG--DLTRENVNQCI 300 + + DL L+ R ++ D + A + G + T E + Sbjct: 209 IILEKLTDLHTYASELLQGMRGKVLP--------DTVIARLAAAQDGLTETTPEQTVHQL 260 Query: 301 LEMLIAAP-DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENF 359 + IA T SL A++P E + + V +N Sbjct: 261 ALVFIALFAPTTPGSLSSGTLAFARNPRQVERFLADQACV-----------------DNT 303 Query: 360 IYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENF 418 E +RY R A +D + G ++ G + L +G +R F +PN+F L+ Sbjct: 304 ANEVLRYNASNQFTWRVAAKDVEMGGVRIEAGQTLALFLGSANRDANMFERPNDFDLDRP 363 Query: 419 AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCV 468 FG G C + + +K V LL RF G+ + Sbjct: 364 N----SARHLSFGQGVHACLAAQLISLQLKWFYVALLNRFPGIRTAGEPI 409 >6F88-A nrPDB Length = 400 Score = 121 bits (302), Expect = 9e-28, Method: Composition-based stats. Identities = 58/364 (15%), Positives = 116/364 (31%), Gaps = 42/364 (11%) Query: 98 SKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGL 157 + Y + G+ G+ E R + + Sbjct: 39 GMPILLRKSHITTAYRDTATFSTRMFQAGILNGGLAAMQGDEH-ARMRRVYNMFFLPRAV 97 Query: 158 VRMVTVCAESL-KTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVK 216 + + + +DRL VD+L D + L R+ + + Sbjct: 98 SQYEERFVRPISEQVVDRLA----GKPRVDLLE-------DFAMELPRRVIGELFGFPAE 146 Query: 217 IQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECM 276 D +++ + + +++ + I ++ E+ R +++ L E Sbjct: 147 KLHETDERVRAMLRGLVRMHDPAAVAESQRAYGETLGLITEVV-ERESRDTSDTLLGE-- 203 Query: 277 DFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEI 336 + AE T E Q +L +++ +T S + + + HP+ + Sbjct: 204 --ILRTLKAEHMD--TIEASRQIVLSLILGGYETTSWLVANTIHALLAHPDTLARV---- 255 Query: 337 QTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNI-I 395 Q ++ I E MR+ P V+R D +D + GT + + Sbjct: 256 -------------RQDPSLLPAAIEEGMRWCPSNFGVLRMVERDVRLDDQALSAGTVVCL 302 Query: 396 LNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLL 455 I + +P P + ++ K +P FG G C G +A + + L LL Sbjct: 303 AGIAGNYDETAYPSPEVYDIDR--KPLPAANV--FGGGAHFCVGAPLARMEARVGLQALL 358 Query: 456 RRFH 459 RF Sbjct: 359 ARFP 362 >6G5O-A nrPDB Length = 399 Score = 117 bits (293), Expect = 1e-26, Method: Composition-based stats. Identities = 64/347 (18%), Positives = 111/347 (31%), Gaps = 52/347 (14%) Query: 130 KGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLT 189 + I F +P + R P + ++ T G V+V+T Sbjct: 69 RQIPFEVDPPVHGVYRAIVEPWFKRPLQAEYQEKLTAQISEIVEE----TLLKGSVEVVT 124 Query: 190 LLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVK 249 + + TL L P ES ISW + + Sbjct: 125 DFALRLQSRALTLLLNTPFSESET----------------------WISWGTHVFRSEGE 162 Query: 250 DLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRG-DLTRENVNQCILEMLIAAP 308 L ++ D + L+ +E G LT+E V ++ Sbjct: 163 ALDGDKANILYHYIDEQIDRASENPGDDMYSVLLNSEFEGRKLTKEEVKGVMVLTFAGGR 222 Query: 309 DTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQP 368 DT+ ++ + +A+HP E + KE ++ + E +RY Sbjct: 223 DTVINAVTNSIAYLAEHPEALERLRKE-----------------PEITGRAVEEMIRYFS 265 Query: 369 VVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRL-EFFPKPNEFTLENFAKNVPYRYF 427 + + R ED + + VK + I L +R F PNE L+ Sbjct: 266 PLTQMGRVVTEDTHVCEHAVKADSRISLCWASANRDAAVFENPNEIVLDRKVNP-----H 320 Query: 428 QPFGFGPRGCAGKYIAMVMMKAILVTLLRRF-HVKTLQ-GQCVESIQ 472 FGF C G A ++K +L TL ++ + L + +E + Sbjct: 321 VGFGFSHHNCLGATHARQILKILLQTLAQKVASFEILDYKENIEDLD 367 >2WIY-A nrPDB Length = 394 Score = 117 bits (292), Expect = 1e-26, Method: Composition-based stats. Identities = 62/392 (15%), Positives = 120/392 (30%), Gaps = 42/392 (10%) Query: 77 YNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNN 136 + R + V + T ++S+ + + H K S G + + + Sbjct: 25 WYRRLQQDHPVHKLEDGTYLVSRYADVSHFAKLPIMSVEPGWADAGPWAVASDTALGSDP 84 Query: 137 NPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVML 196 R K + ++V + + + L + ++ L V Sbjct: 85 PHHT--VLRRQTNKWFTP----KLVDGWVRTTRELVGDLLDGVEAGQVIEARRDLAVVPT 138 Query: 197 DTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIE 256 + L++P D++ DA + + + +++ + Sbjct: 139 HVTMARVLQLPEDDA----------DAVMEAMFEAMLMQSAEPADGDVDRAAVAF-GYLS 187 Query: 257 VLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLF 316 +AE ++++ A L+ A + G++T IL + + Sbjct: 188 ARVAEMLE----DKRVNPGDGLADSLLDAARAGEITESEAIATILVFYAVGHMAIGYLIA 243 Query: 317 FMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRK 376 + L A+ P V A + I E +R P +R Sbjct: 244 SGIELFARRPEVFTAFRNDESA-----------------RAAIINEMVRMDPPQLSFLRF 286 Query: 377 ALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYFQPFGFGPR 435 ED I G ++ G+ I IG +R E F P+ F FG GP Sbjct: 287 PTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHTR---PPAASRNLSFGLGPH 343 Query: 436 GCAGKYIAMVMMKAILVTLLRRFHVKTLQGQC 467 CAG+ I+ + L R+ L + Sbjct: 344 SCAGQIISRAEATTVFAVLAERYERIELAEEP 375 >2NZA-A nrPDB Length = 413 Score = 115 bits (287), Expect = 5e-26, Method: Composition-based stats. Identities = 59/392 (15%), Positives = 124/392 (31%), Gaps = 57/392 (14%) Query: 82 GEFMRVWISGEE--TLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEK----GIIFN 135 G RV + E + ++ + I + ++ + + H K + F Sbjct: 40 GPLTRVRLPHGEGWAWLATRYDDVKAITNDPRFGRAEVTQRQITRLAPHFKPRPGSLAFA 99 Query: 136 NNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVM 195 + P+ R A + R+ E L +D + + V+ Sbjct: 100 DQPDH-NRLRRAVAGAFTVGATKRLRPRAQEILDGLVDGILAEGPPADLVE--------- 149 Query: 196 LDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAI 255 + + + + + +W +I S + E++ + L I Sbjct: 150 -RVLEPFPIAVVSEVMGVPAADRERVHSWTRQIIS------TSGGAEAAERAKRGLYGWI 202 Query: 256 EVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSL 315 + + E D + L A RG++ + I + ++ ++ Sbjct: 203 TETVRARAG--------SEGGDVYSMLGAAVGRGEVGETEAVGLAGPLQIGG-EAVTHNV 253 Query: 316 FFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQP--VVDLV 373 ML+L+ + + + G R +D E +R+ + Sbjct: 254 GQMLYLLLTRRELMARMRERP----GARGTALD-------------ELLRWISHRTSVGL 296 Query: 374 MRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAKNVPYRYFQPFGF 432 R ALED + G + G + ++ +R + FP P+ L+ +G Sbjct: 297 ARIALEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDLDRDPNP-----HLAYGN 351 Query: 433 GPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQ 464 G C G +A + + ++ TLL R L Sbjct: 352 GHHFCTGAVLARMQTELLVDTLLERLPGLRLA 383 >3OFT-A nrPDB Length = 396 Score = 114 bits (286), Expect = 8e-26, Method: Composition-based stats. Identities = 58/346 (16%), Positives = 112/346 (32%), Gaps = 67/346 (19%) Query: 149 MKALSGPGLVRMVTVCAESLK----THLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFL 204 KA P + + + +L+ +L E G D ++ D + L L Sbjct: 94 HKAFRTPVMKGLASRFVVALEPKVQAVARKLMESLRPRGSCDFVS-------DFAEILPL 146 Query: 205 RIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRR 264 I L + ++ + L +PD + L + + D + I ++ Sbjct: 147 NIFLTLIDVPLEDRPRLRQLGVQLTRPDGSMTVEQLKQAAD-------DYLWPFIEKR-- 197 Query: 265 RISTEEKLEECMDFATELILAEKRG-DLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIA 323 + D + ++ G T + + +L DT++ + + +A Sbjct: 198 ------MAQPGDDLFSRILSEPVGGRPWTVDEARRMCRNLLFGGLDTVAAMIGMVALHLA 251 Query: 324 KHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI 383 +HP + + + + ++ E MR P V V R A+ D Sbjct: 252 RHPEDQRLLRE-----------------RPDLIPAAADELMRRYPTV-AVSRNAVADVDA 293 Query: 384 DGYPVKKGTNIILNIGRMH--RLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKY 441 DG ++KG + L +H F P E F + + G G C G Sbjct: 294 DGVTIRKGDLVYL-PSVLHNLDPASFEAPEE---VRFDRGLAPIRHTTMGVGAHRCVGAG 349 Query: 442 IAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNM 487 +A + + L E + + + +L PD+ M Sbjct: 350 LARMEVIVFLR----------------EWLGGMPEFALAPDKAVTM 379 >3AWQ-A nrPDB Length = 415 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 50/344 (14%), Positives = 107/344 (31%), Gaps = 39/344 (11%) Query: 142 KTTRP-FFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSN 200 R FM ++ + + + + + Y ++ L R + Sbjct: 91 HRHRKQMFMGLMTPERVRALAQLFEAEWRRAVPGWTRKGEIVFYDELHEPLTRAV----- 145 Query: 201 TLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIA 260 + +PL + + L D S + + + + + +I Sbjct: 146 CAWAGVPLPDDEAGNRA-------GELRALFDAAGSASPRHLWSRLARRRVDAWAKRIIE 198 Query: 261 EKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLF 320 R + ++ DL +V +E++ T++++++ Sbjct: 199 GIR---AGSIGSGSGTAAYAIAWHRDRHDDLLSPHVA--AVELVNVLRPTVAIAVYITF- 252 Query: 321 LIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALED 380 V A+ I+ +Q+ E F+ E R+ P V+ +A +D Sbjct: 253 -------VAHALQT-------CSGIRAALVQQPDYAELFVQEVRRFYPFFPAVVARASQD 298 Query: 381 DVIDGYPVKKGTNIILNIG-RMHRLEFFPKPNEFTLENFAK-NVPYRYFQPFGFGP---- 434 +G +G ++L++ H + P EF E F + F P G G Sbjct: 299 FEWEGMAFPEGRQVVLDLYGSNHDAATWADPQEFRPERFRAWDEDSFNFIPQGGGDHYLG 358 Query: 435 RGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLS 478 C G++I + +MK L+ ++ L Sbjct: 359 HRCPGEWIVLAIMKVAAHLLVNAMRYDVPDQDLSIDFARLPALP 402 >5M0P-A nrPDB Length = 428 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 67/403 (16%), Positives = 135/403 (33%), Gaps = 50/403 (12%) Query: 89 ISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIG----MHEKGIIFNNNPELWKTT 144 + G+ ++++ Y++ + G+ + KG I + + Sbjct: 47 LGGKPFVVVTGKEGAEMF-----YNNDVVQREGMLPKRIVNTLAGKGAIHTVDGKKHVDR 101 Query: 145 RPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFL 204 + FM ++ L + + + R+E + + Y + + LL +V T Sbjct: 102 KALFMSLMTEGNLNYVRELTRTLWHANTQRMESMDEVNIYRESIVLLTKV--GTRWAGVQ 159 Query: 205 RIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRR 264 P D I + D+++AL YK +++ + ++D +E I E R+ Sbjct: 160 APPEDIERIATDMDIMIDSFRAL-------GGAFKGYKASKEARRRVEDWLEEQIIETRK 212 Query: 265 RISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVS--LFFMLFLI 322 + A + + C ++++ ++++ + F L + Sbjct: 213 -----GNIHPPEGTALYEFAHWEDYLGNPMDSRTCAIDLMNTFRPLIAINRFVSFGLHAM 267 Query: 323 AKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDV 382 ++P E I E F E RY P V + KA D Sbjct: 268 NENPITREKIKSEPD-----------------YAYKFAQEVRRYYPFVPFLPGKAKVDID 310 Query: 383 IDGYPVKKGTNIILN-IGRMHRLEFFPKPNEFTLENFA--KNVPYRYFQPFGFGP----R 435 G + G + L+ G H + PNEF E F P+ P G G Sbjct: 311 FQGVTIPAGVGLALDVYGTTHDESLWDDPNEFRPERFETWDGSPFD-LIPQGGGDYWTNH 369 Query: 436 GCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLS 478 CAG++I +++M+ + + + + I Sbjct: 370 RCAGEWITVIIMEETMKYFAEKITYDVPEQDLEVDLNSIPGYV 412 >6G71-A nrPDB Length = 405 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 59/374 (15%), Positives = 118/374 (31%), Gaps = 49/374 (13%) Query: 95 LIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSG 154 LI S S + + +S+ L L ++ ++P+ + R + +L Sbjct: 46 LITSYSGVLAADVDQTTFSANEKKSLML---RAMGHSMLRKDDPDH-QVERRAWQPSLKP 101 Query: 155 PGLVRMVT-VCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAI 213 + ++ AE+ +LD Y+D + M + Sbjct: 102 GTVKKVWKQKFAENADRYLD---------AYIDAGSG-SDFMQGFAAPFVAENLRALIGF 151 Query: 214 VVKIQGYFDAWQALLIKPDIFFKI-SWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKL 272 + W LI + ++ K ++S ++ A+E +I R Sbjct: 152 ENASEADLQRWSQTLIDGAGNYPDDPDVWAKAKQSSDEIDAALEEMIQWHSGRPG----- 206 Query: 273 EECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAI 332 D +L + E++ I + + L + E + Sbjct: 207 ----DSLLSYLLRSADYQMPLESIRSNIKMTIGGGLNEPRDVLGVSTLALLSSSKQLELV 262 Query: 333 IKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGT 392 ++ K+ ES+R+ + +V R+ + D +DGY + +G Sbjct: 263 -----------------LRDPKLWGAVFEESIRWVAPIGMVPRQTVVDTELDGYFIPRGA 305 Query: 393 NIILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMK-AI 450 + L I +R + P+ F +E ++ FG G C G + A + Sbjct: 306 KLGLCILSANRDRSVWSDPDRFDIERGSE-----AHLAFGKGVHVCLGAWAARSQVADVG 360 Query: 451 LVTLLRRFHVKTLQ 464 L L R L Sbjct: 361 LPALFSRLKGLRLD 374 >4FB2-A nrPDB Length = 398 Score = 105 bits (262), Expect = 4e-23, Method: Composition-based stats. Identities = 49/325 (15%), Positives = 106/325 (32%), Gaps = 51/325 (15%) Query: 142 KTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNT 201 K R K S + E L+ + L + E G D T L +N Sbjct: 93 KKYRQLVAKPFSPEA----TDLFTEQLRQSTNDLIDARIELGEGDAATWL-------ANE 141 Query: 202 LFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAE 261 + R+ + + + W + ++ ++ + L+A Sbjct: 142 IPARLTAILLGLPPEDGDTYRRWVWAITHV--------------ENPEEGAEIFAELVAH 187 Query: 262 KRRRISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAAPDTMSVSLFFMLF 320 R I+ E + D + +I+++ G+ L+ +++ +L+ D + L + + Sbjct: 188 ARTLIA-ERRTNPGNDIMSRVIMSKIDGESLSEDDLIGFFTILLLGGIDNTARFLSSVFW 246 Query: 321 LIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALED 380 +A + + I +++ N + E +R+ +V R ++ Sbjct: 247 RLAWDIELRRRL-----------------IAHPELIPNAVDELLRFYGPA-MVGRLVTQE 288 Query: 381 DVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAG 439 + +K G +L R F P+ +E G G C G Sbjct: 289 VTVGDITMKPGQTAMLWFPIASRDRSAFDSPDNIVIERTPNR-----HLSLGHGIHRCLG 343 Query: 440 KYIAMVMMKAILVTLLRRFHVKTLQ 464 ++ V + + L+R +L Sbjct: 344 AHLIRVEARVAITEFLKRIPEFSLD 368 >5KYO-A nrPDB Length = 430 Score = 102 bits (255), Expect = 3e-22, Method: Composition-based stats. Identities = 64/408 (15%), Positives = 124/408 (30%), Gaps = 58/408 (14%) Query: 80 VYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKG---IIFNN 136 +W ++ S + + + RF + L + I + Sbjct: 68 RQAPHPLMWTPHNGGHWVALRSDLAETVMSD--FERFSNHTVLVPKETAGEAYRLIPLSL 125 Query: 137 NPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVML 196 +P + R + L L + V + + ++ Sbjct: 126 DPPEHRPFRSLLNENLGPKPLRPIEQVVTDLAVSLIEGFRPKG-----------RCNFTH 174 Query: 197 DTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIE 256 + + L +RI + + V+ +PD + + K ++ + Sbjct: 175 EFAEQLPVRIFMRIVDLPVEDLPKLKHLADQYTRPDGSIPL-------DDVTKQFREYLR 227 Query: 257 VLIAEKRRRISTEEKLEECMDFATELILAEKRG-DLTRENVNQCILEMLIAAPDTMSVSL 315 +I +R ++ D + +I E G LT +++L+ DT+ L Sbjct: 228 PVIEARR--------IKPGEDMISRMINGEVGGRPLTDIEAENICIQVLVGGLDTVVNML 279 Query: 316 FFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMR 375 F +AK + AI ++++ + E R PVV R Sbjct: 280 GFTFSHLAKDHALRRAIA-----------------ADPSLIDDALLEFFRRFPVVSSA-R 321 Query: 376 KALEDDVIDGYPVKKGTNIILNIGRMH-RLEFFPKPNEFTLENFAKNVPYRYFQPFGFGP 434 + L D +G +K G ++ + P EF L R FG G Sbjct: 322 EVLRDQEFEGVLLKAGDMVMAPTVVVAMDDARNEDPLEFRLGR-----KARQHSTFGKGS 376 Query: 435 RGCAGKYIAMVMMKAILVTLLRRFH-VKTLQGQCVESIQKIHDLSLHP 481 C G ++A + MK +L R + + I S+ P Sbjct: 377 HTCPGAHLARMEMKVVLREWFARIPEFRIEDDAPLRYSNGIVG-SVKP 423 >2IJ7-A nrPDB Length = 396 Score = 99.5 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 52/390 (13%), Positives = 110/390 (28%), Gaps = 55/390 (14%) Query: 83 EFMRVW-ISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELW 141 +V I+G E ++S + +++ +S + + G + PE+ Sbjct: 30 PIRKVRTITGAEAWLVSSYALCTQVLEDRRFSMKETAAAGAPRLN------ALTVPPEVV 83 Query: 142 KTTRPFFMKALSGPGLVRMVTVCAESLKTHLD-----RLEEVTNESGYVDVLTLLRRVML 196 L + + A L+ L L+ + E D+ + Sbjct: 84 NNMGNIADAGLRKAVMKAITPK-APGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLA 142 Query: 197 DTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIE 256 + L IP ++ + + A + D + + Sbjct: 143 TALHCKVLGIPQEDGPKLFR-----SLSIAFMSSADPIPAAKINWDRD------------ 185 Query: 257 VLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLF 316 I + M + L ++ E + A + L Sbjct: 186 --IEYMAGILENPNITTGLMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLT 243 Query: 317 FMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQ-PVVDLVMR 375 L + + P + + + K +++ + E +R D + R Sbjct: 244 TALISLIQRPQLRNLLHE-----------------KPELIPAGVEELLRINLSFADGLPR 286 Query: 376 KALEDDVIDGYPVKKGTNIILNIGRMH-RLEFFPKPNEFTLENFAKNVPYRYFQPFGFGP 434 A D + V+KG +++ + + E FP P L+ FG G Sbjct: 287 LATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPT----SHLAFGRGQ 342 Query: 435 RGCAGKYIAMVMMKAILVTLLRRFHVKTLQ 464 C G + + + LL++ L Sbjct: 343 HFCPGSALGRRHAQIGIEALLKKMPGVDLA 372 >5OMS-A nrPDB Length = 409 Score = 97.5 bits (241), Expect = 1e-20, Method: Composition-based stats. Identities = 50/321 (15%), Positives = 105/321 (32%), Gaps = 42/321 (13%) Query: 143 TTRPFFMKALSGPGLVR-MVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNT 201 R AL + R + + + +L+R E G+ +++ + S Sbjct: 92 DLRSMVEPALQPAEVDRWIDDLVRPIARRYLERFE----NDGHAELVAQYCEPVSVRSLG 147 Query: 202 LFLRIP-LDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIA 260 L + +D + ++ + + F + + +++ +++ ++ LI Sbjct: 148 DLLGLQEVDSDKLREWFAKLNRSFTNAAVDENGEFANPEGFAEGDQAKAEIRAVVDPLID 207 Query: 261 EKRRRISTEEKLEECMDFATELILAE---KRGDLTRENVNQCILEMLIAAPDTMSVSLFF 317 + +E D A L + RE + I L+ A + Sbjct: 208 ---------KWIEHPDDSAISHWLHDGMPPGQTRDREYIYPTIYVYLLGAMQEPGHGMAS 258 Query: 318 MLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVM-RK 376 L + P E + + ++ I E +R+ + R Sbjct: 259 TLVGLFSRPEQLEEV-----------------VDDPTLIPRAIAEGLRWTSPIWSATARI 301 Query: 377 ALEDDVIDGYPVKKGTNIILNIGRMHRLE-FFPKPNEFTLENFAKNVPYRYFQPFGFGPR 435 + + I G + GT ++L+ G + + P+++ L P FG G Sbjct: 302 STKPVTIAGVDLPAGTPVMLSYGSANHDTGKYEAPSQYDLHR-----PPLPHLAFGAGNH 356 Query: 436 GCAGKYIAMVMMKAILVTLLR 456 CAG Y A +M+ L L Sbjct: 357 ACAGIYFANHVMRIALEELFE 377 >2QBO-A nrPDB Length = 421 Score = 96.0 bits (237), Expect = 3e-20, Method: Composition-based stats. Identities = 50/340 (14%), Positives = 108/340 (31%), Gaps = 50/340 (14%) Query: 137 NPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVML 196 +P + R + + P + ++ E + ++ L G + Sbjct: 105 DPPEQRQFRALANQVVGMPVVDKLENRIQELACSLIESLR----PQGQCNFTE------- 153 Query: 197 DTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIE 256 D + +RI + + + + + + +PD + ++ + L D + Sbjct: 154 DYAEPFPIRIFMLLAGLPEEDIPHLKYLTDQMTRPDGSM-------TFAEAKEALYDYLI 206 Query: 257 VLIAEKRRRISTEEKLEECMDFATELILAEKRG-DLTRENVNQCILEMLIAAPDTMSVSL 315 +I ++R++ D + + + G +T + + +L+ DT+ L Sbjct: 207 PIIEQRRQK--------PGTDAISIVANGQVNGRPITSDEAKRMCGLLLVVGLDTVVNFL 258 Query: 316 FFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMR 375 F + +AK P + +I+ + + E +R +V R Sbjct: 259 SFSMEFLAKSPEHRQELIERPER-----------------IPAACEELLRRFSLVADG-R 300 Query: 376 KALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPR 435 D G +KKG I+L E + + FG G Sbjct: 301 ILTSDYEFHGVQLKKGDQILLPQMLSGLDER----ENACPMHVDFSRQKVSHTTFGHGSH 356 Query: 436 GCAGKYIAMVMMKAILVTLLRRF-HVKTLQGQCVESIQKI 474 C G+++A + L L R G ++ I Sbjct: 357 LCLGQHLARREIIVTLKEWLTRIPDFSIAPGAQIQHKSGI 396 >2RCM-A nrPDB Length = 495 Score = 94.5 bits (233), Expect = 1e-19, Method: Composition-based stats. Identities = 68/451 (15%), Positives = 150/451 (33%), Gaps = 50/451 (11%) Query: 46 SIPGPGYCMGIGPLISHGRFLW-MGIGSACNYYNRVYGE-FMRVWISGEETLIISKSSSM 103 +IPG +GP+ + + G R Y RV + I+++ + Sbjct: 29 NIPGNYGLPIVGPIKDRWDYFYDQGAEEFFKSRIRKYNSTVYRVNM--PPGAFIAENPQV 86 Query: 104 FHIMKHNHYSSRF----GSKLGLQCIGMHEKG--------IIFNNNPELWKTTRPFFMKA 151 ++ + F K L + + + E + Sbjct: 87 VALLDGKSFPVLFDVDKVEKKDLLTGTYMPSTELTGGYRILSYLDPSEPKHEKLKNLLFF 146 Query: 152 LSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDES 211 L R+ + D LE+ + G D + F ++ Sbjct: 147 LLKSSRNRIFPEFQATYSELFDSLEKELSLKGKADFGGSSDGTAFNFLARAFYGTNPADT 206 Query: 212 AIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEK 271 + G W + P + + + ++ L A+ + + Sbjct: 207 KLKADAPGLITKWVLFNLHPLLSIGLPRVIEEPLIHTFSLPPALV--------KSDYQRL 258 Query: 272 LEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKH-----P 326 E ++ A E+++ + ++RE +L A + + + K Sbjct: 259 YEFFLESAGEILVEADKLGISREEATHN---LLFATCFNTWGGMKILFPNMVKRIGRAGH 315 Query: 327 NVEEAIIKEIQTVIGER--DIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVID 384 V + +EI++VI ++ + I+K+++ ++ +YE +R++P V +A +D VI+ Sbjct: 316 QVHNRLAEEIRSVIKSNGGELTMGAIEKMELTKSVVYECLRFEPPVTAQYGRAKKDLVIE 375 Query: 385 GY----PVKKGTNII-LNIGRMHRLEFFPKPNEFTLENF--AKNVPYRYFQPFGFGP--- 434 + VK G + + F + +EF E F + + GP Sbjct: 376 SHDAAFKVKAGEMLYGYQPLATRDPKIFDRADEFVPERFVGEEGEKLLRHVLWSNGPETE 435 Query: 435 ------RGCAGKYIAMVMMKAILVTLLRRFH 459 + CAGK +++ + ++ + RR+ Sbjct: 436 TPTVGNKQCAGKDFVVLVARLFVIEIFRRYD 466 >3DBM-A nrPDB Length = 473 Score = 91.8 bits (226), Expect = 7e-19, Method: Composition-based stats. Identities = 58/446 (13%), Positives = 141/446 (31%), Gaps = 41/446 (9%) Query: 47 IPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRV----------WISGEETLI 96 IPG P+ + + G G Y+ ++ ++S +I Sbjct: 11 IPGSYGIPFFQPIKDRLEYFY-GTGGRDEYFRSRMQKYQSTVFRANMPPGPFVSSNPKVI 69 Query: 97 ISKS----SSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKAL 152 + +F + K G+ + + + + + + E + + Sbjct: 70 VLLDAKSFPILFDVSKVEKKDLFTGTYMPSTKLTGGYRVLSYLDPSEPRHAQLKNLLFFM 129 Query: 153 SGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESA 212 R++ + + LE ++G + + + +E+ Sbjct: 130 LKNSSNRVIPQFETTYTELFEGLEAELAKNGKAAFNDVGEQAAFRFLGRAYFNSNPEETK 189 Query: 213 IVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKL 272 + +W + P + + W ++ L + K Sbjct: 190 LGTSAPTLISSWVLFNLAPTLDLGLPWFLQEPLLHTFRLPAFLIKSTYNKLYDYFQSVAT 249 Query: 273 EECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTM-SVSLFFMLFLIAKHPNVEEA 331 + D N+ + + +L ++ N+ Sbjct: 250 P----VMEQAEKLGVPKDEAVHNILFAVCFNTFGGVKILFPNTLKWIGLA---GENLHTQ 302 Query: 332 IIKEIQTVI---GERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGY-- 386 + +EI+ I G+ ++ ++ I+++ + ++ +YES+R +P V KA + I+ + Sbjct: 303 LAEEIRGAIKSYGDGNVTLEAIEQMPLTKSVVYESLRIEPPVPPQYGKAKSNFTIESHDA 362 Query: 387 --PVKKGTNII-LNIGRMHRLEFFPKPNEFTLENF-AKNVPYRYFQPFGFGP-------- 434 VKKG + + F +P E+ + F + + GP Sbjct: 363 TFEVKKGEMLFGYQPFATKDPKVFDRPEEYVPDRFVGDGEALLKYVWWSNGPETESPTVE 422 Query: 435 -RGCAGKYIAMVMMKAILVTLLRRFH 459 + CAGK +++ + ++ L RR+ Sbjct: 423 NKQCAGKDFVVLITRLFVIELFRRYD 448 >3NV6-A nrPDB Length = 452 Score = 85.6 bits (210), Expect = 4e-17, Method: Composition-based stats. Identities = 59/330 (17%), Positives = 112/330 (33%), Gaps = 46/330 (13%) Query: 137 NPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVML 196 +P R K L+ + ++ E + +D G D + Sbjct: 140 DPPEHTPYRKALDKGLNLAKIRKVEDKVREVASSLIDSFAA----RGECDFAAEYAELFP 195 Query: 197 DTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIE 256 +PL++ ++ + + + E ++ Sbjct: 196 VHVFMALADLPLEDIPVLSEYARQMTRPEGNTP--------EEMATDLEAGNNGFYAYVD 247 Query: 257 VLIAEKRRRISTEEKLEECMDFATELILAEKRGD-LTRENVNQCILEMLIAAPDTMSVSL 315 +I R R+ + D T ++ +E G+ + + I +L+ DT+ L Sbjct: 248 PII---RARVGG-----DGDDLITLMVNSEINGERIAHDKAQGLISLLLLGGLDTVVNFL 299 Query: 316 FFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMR 375 F + +A+HP + + + LK+M E R PVV R Sbjct: 300 SFFMIHLARHPELVAELRSDP----------------LKLMRGA-EEMFRRFPVVSEA-R 341 Query: 376 KALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPR 435 +D G +K+G I+L +H L+ P + L+ +++ FG GP Sbjct: 342 MVAKDQEYKGVFLKRGDMILL-PTALHGLDDAANPEPWKLDFSRRSI---SHSTFGGGPH 397 Query: 436 GCAGKYIAMVMMKAILVTLLRR---FHVKT 462 CAG ++A + + L L+R F K Sbjct: 398 RCAGMHLARMEVIVTLEEWLKRIPEFSFKE 427 >3B98-A nrPDB Length = 475 Score = 84.4 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 67/449 (14%), Positives = 147/449 (32%), Gaps = 50/449 (11%) Query: 51 GYCMGIGPLISHGRFLWMGIGSACNYYNR---VYGEFMRVWISGEETLIISKSSSMFHIM 107 G +G + G+ A + R +G+ V +G + + S+ + + Sbjct: 25 GMIPWLGHALEFGK-------DAAKFLTRMKEKHGDIFTVRAAGLY-ITVLLDSNCYDAV 76 Query: 108 KHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKA-LSGPGLVRMVTVCAE 166 + S S + + + +N K F A L+ + Sbjct: 77 LSDVASLDQTSYAQVLMKRIFNMILPSHNPESEKKRAEMHFQGASLTQLSNSMQNNLRLL 136 Query: 167 SLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQA 226 + + + G + L ++ T + SA + +I F + Sbjct: 137 MTPSEMGLKTSEWKKDG---LFNLCYSLLFKTGYLTVFGAENNNSAALTQIYEEFRRFDK 193 Query: 227 LLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAE 286 LL K + + + L + +++ R + + + Sbjct: 194 LLPKLARTTVNKEEKQIASAAREKLWKWLTPSGLDRKPREQS---------WLGSYVKQL 244 Query: 287 KRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIK 346 + + E + +L L + F+++ + HP A+ +EIQ G + ++ Sbjct: 245 QDEGIDAEMQRRAMLLQLWVTQGNAGPAAFWVMGYLLTHPEALRAVREEIQ---GGKHLR 301 Query: 347 IDDIQK-LKVMENFIYESMRYQPVVDLVMRKALEDDVI-----DGYPVKKGT--NIILNI 398 +++ QK V ++ ++E++R L+ R +D I Y +++G + I Sbjct: 302 LEERQKNTPVFDSVLWETLRL-TAAALITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFI 360 Query: 399 GRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRG-------------CAGKYIAMV 445 + +P F + F F G R C G++ A+ Sbjct: 361 SPQMDPQIHQQPEMFQFDRFLNADRTEKKDFFKNGARVKYPSVPWGTEDNLCPGRHFAVH 420 Query: 446 MMKAILVTLLRRFHVKTLQ-GQCVESIQK 473 +K ++ T+L RF V+ V + Sbjct: 421 AIKELVFTILTRFDVELCDKNATVPLVDP 449 >4C9K-A nrPDB Length = 421 Score = 84.1 bits (206), Expect = 1e-16, Method: Composition-based stats. Identities = 53/336 (15%), Positives = 108/336 (32%), Gaps = 47/336 (13%) Query: 137 NPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVML 196 +P R K L+ + ++ + ++T + E + G+ + + V Sbjct: 106 DPPEHTPYRKAIDKGLNLAEIRKLE----DQIRTIAVEIIEGFADRGHCEFGSEFSTVFP 161 Query: 197 DTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIE 256 +P++++ + + + E + K + + Sbjct: 162 VRVFLALAGLPVEDATKLGLLANEMTRPSGNTP--------EEQGRSLEAANKGFFEYVA 213 Query: 257 VLIAEKRRRISTEEKLEECMDFATELILAEKRG-DLTRENVNQCILEMLIAAPDTMSVSL 315 +IA +R D T ++ E G + + + +L+ DT+ L Sbjct: 214 PIIAARRG--------GSGTDLITRILNVEIDGKPMPDDRALGLVSLLLLGGLDTVVNFL 265 Query: 316 FFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMR 375 FM+ +++HP + +E ++ + E R VV R Sbjct: 266 GFMMIYLSRHPETVAEMRREPLK-----------------LQRGVEELFRRFAVVSDA-R 307 Query: 376 KALEDDVIDGYPVKKGTNIILNIGRMH--RLEFFPKPNEFTLENFAKNVPYRYFQPFGFG 433 + D G +K+G I+L +H P L F G Sbjct: 308 YVVSDMEFHGTMLKEGDLILL-PTALHGLDDRHHDDPMTVDLSRRDVT-----HSTFAQG 361 Query: 434 PRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVE 469 P CAG ++A + + +L L R L+ + V Sbjct: 362 PHRCAGMHLARLEVTVMLQEWLARIPEFRLKDRAVP 397 >2IAG-A nrPDB Length = 482 Score = 82.1 bits (201), Expect = 5e-16, Method: Composition-based stats. Identities = 64/482 (13%), Positives = 146/482 (30%), Gaps = 62/482 (12%) Query: 48 PGPGYC-----MGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSS 102 PG +G + G+ + +G+ + + G ++ S Sbjct: 5 PGEPPLDLGSIPWLGYALDFGKDAASFLTRM----KEKHGDIFTILVGGRYVTVLLDPHS 60 Query: 103 MFHIMKHNHYSSRFGSKLGLQCIGMHEKGII-FNNNPELWKTTRPFFMKALSGPGLVRMV 161 ++ F + + + + ++ + E + + L Sbjct: 61 YDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYT 120 Query: 162 TVCAESLKTHLDRLEEVTNESGYVD-VLTLLRRVMLDTSNTLFL--RIPLDESAIVVKIQ 218 + A L + +E G +D + L R T + R ++ V Sbjct: 121 NLHAVLLGDATEAG-SGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSA 179 Query: 219 GYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDF 278 F ++ L + S + ++L + R + K E Sbjct: 180 DVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLL 239 Query: 279 ATELILAEKRGDLTRENVNQCILEM-LIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQ 337 E + E + L + L A M + F++L + K+P A+ E++ Sbjct: 240 HLEEMGVS-------EEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELE 292 Query: 338 TVIGERDIKIDD--------IQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI-----D 384 +++ + + + + V+++ + ES+R + R+ + D + Sbjct: 293 SILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-TAAPFITREVVVDLAMPMADGR 351 Query: 385 GYPVKKGTNIILNIGRMH--RLEFFPKPNEFTLENFAKNVPYR-------------YFQP 429 + +++G ++L E + P F F Y P Sbjct: 352 EFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMP 411 Query: 430 FGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKT-----------LQGQCVESIQKIHDLS 478 +G G C G+ A+ +K + +L ++ L +Q HD+ Sbjct: 412 WGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVP 471 Query: 479 LH 480 + Sbjct: 472 VR 473 >2YJN-B nrPDB Length = 381 Score = 57.1 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 17/129 (13%), Positives = 45/129 (34%), Gaps = 18/129 (13%) Query: 300 ILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENF 359 L L A + + ++ + ++ P + E I + + Sbjct: 216 ALRALFAGAEMTANTVVDAVLAVSAEPGLAERIADDPAAA-----------------QRT 258 Query: 360 IYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENF 418 + E +R P + L R A + + + + +G +++ + +R E F +P+ ++ Sbjct: 259 VAEVLRLHPALHLERRTATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDRLDVDRP 318 Query: 419 AKNVPYRYF 427 + Sbjct: 319 DADRALSAH 327 >4YXC-B nrPDB Length = 227 Score = 32.4 bits (72), Expect = 0.45, Method: Composition-based stats. Identities = 32/194 (16%), Positives = 63/194 (32%), Gaps = 9/194 (4%) Query: 206 IPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRR 265 L+ A I L + + + V L + + R Sbjct: 17 SELELVANFADIPLRLSQILKLKPGDVLPIEKPDRIIAHVDGVPVLTSQYGTVNGQYALR 76 Query: 266 ISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKH 325 + E + ++ E D ++ + L T + S +F Sbjct: 77 V--EHLINPILNSLNEEQPKNNPSDENTGALDDLWADALNEQKATTTKSAADAVFQQLGG 134 Query: 326 PNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRY-QPVVDLVMRKALE--DDV 382 +V A+ +I ++ DI + +L I E +R Q V + A E D + Sbjct: 135 GDVSGAMQ-DIDLIM---DIPVKLTVELGRTRMTIKELLRLTQGSVVALDGLAGEPLDIL 190 Query: 383 IDGYPVKKGTNIIL 396 I+GY + +G +++ Sbjct: 191 INGYLIAQGEVVVV 204 >1PUJ-A nrPDB Length = 282 Score = 32.1 bits (71), Expect = 0.56, Method: Composition-based stats. Identities = 30/183 (16%), Positives = 66/183 (36%), Gaps = 12/183 (6%) Query: 135 NNNPELWKTT------RPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVL 188 + WK R + +++G GL ++V E L+ DR+ + Sbjct: 65 AAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKEILQEKFDRMRA--KGVKPRAIR 122 Query: 189 TLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISW--LYKKYEK 246 L+ + +TL R+ A G + Q + + ++ + L+ K+E Sbjct: 123 ALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQWVKVGKELELLDTPGILWPKFED 182 Query: 247 SVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIA 306 + L+ A+ I + I+ ++ + F E + + + + I E+ A Sbjct: 183 ELVGLRLAVTGAIKD--SIINLQDVAVFGLRFLEEHYPERLKERYGLDEIPEDIAELFDA 240 Query: 307 APD 309 + Sbjct: 241 IGE 243 >3RP9-A nrPDB Length = 458 Score = 32.1 bits (71), Expect = 0.57, Method: Composition-based stats. Identities = 15/57 (26%), Positives = 25/57 (43%), Gaps = 4/57 (7%) Query: 323 AKHPNVEEAIIKEIQTVIGER-DIKIDDIQKLK---VMENFIYESMRYQPVVDLVMR 375 HP +E I E++T E+ + +D + + F+ E RY P + L R Sbjct: 395 LAHPFFKEVRIAEVETNATEKVRLPFNDWMNMDEPQLRYAFVKEIQRYHPEIQLPRR 451 >3RFT-A nrPDB Length = 267 Score = 30.9 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 9/55 (16%), Positives = 20/55 (36%), Gaps = 7/55 (12%) Query: 391 GTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMV 445 G I+ H + ++P+ + A+ +G C G+ +A + Sbjct: 102 GQPRIVFASSNHTIGYYPQTERLGPDVPARPDGL-------YGVSKCFGENLARM 149 >7PCK-A nrPDB Length = 314 Score = 28.6 bits (62), Expect = 6.5, Method: Composition-based stats. Identities = 19/103 (18%), Positives = 34/103 (33%), Gaps = 10/103 (9%) Query: 235 FKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRE 294 K+Y V ++ LI EK + + LE + T + GD+T E Sbjct: 13 LWKKTHRKQYNNKVDEIS---RRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSE 69 Query: 295 NVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQ 337 V Q + + + + S ++ P E + Sbjct: 70 EVVQKMTGLKVPLSHSRSNDTLYI-------PEWEGRAPDSVD 105 >5Y77-A nrPDB Length = 473 Score = 28.2 bits (61), Expect = 9.2, Method: Composition-based stats. Identities = 9/64 (14%), Positives = 23/64 (35%) Query: 316 FFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMR 375 + + ++ P + +IQ + + + ++ +E R P + + Sbjct: 404 RYSMVTFSRLPYAQAMARGQIQEQLLKFAVANHSDLTSINLDAVEHEVTRCLPPLSHLCA 463 Query: 376 KALE 379 ALE Sbjct: 464 AALE 467 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.125 0.319 Lambda K H 0.267 0.0385 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 17,333,214 Number of Sequences: 36641 Number of extensions: 692702 Number of successful extensions: 3376 Number of sequences better than 10.0: 174 Number of HSP's better than 10.0 without gapping: 230 Number of HSP's successfully gapped in prelim test: 81 Number of HSP's that attempted gapping in prelim test: 2455 Number of HSP's gapped (non-prelim): 324 length of query: 503 length of database: 10,336,785 effective HSP length: 101 effective length of query: 402 effective length of database: 6,636,044 effective search space: 2667689688 effective search space used: 2667689688 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (20.9 bits) S2: 61 (28.2 bits)