BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P11309 (313 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5TUR-A nrPDB 644 0.0 3BGP-A nrPDB 643 0.0 4RC3-A nrPDB 585 e-168 4X7Q-B nrPDB 333 6e-92 3DLS-A nrPDB 140 8e-34 4YNZ-A nrPDB 138 3e-33 4CQG-A nrPDB 135 3e-32 4MVF-A nrPDB 129 1e-30 5KZ7-A nrPDB 129 1e-30 4D2V-A nrPDB 129 1e-30 5ES1-A nrPDB 129 2e-30 2QNJ-A nrPDB 129 2e-30 5YKS-A nrPDB 129 2e-30 4CZT-A nrPDB 124 4e-29 2YZA-A nrPDB 121 5e-28 4CFF-A nrPDB 119 1e-27 4D28-A nrPDB 119 1e-27 5EZV-A nrPDB 119 1e-27 3MN3-A nrPDB 118 3e-27 3H4J-B nrPDB 117 7e-27 6C9D-A nrPDB 116 1e-26 2HAK-A nrPDB 115 2e-26 4CFH-A nrPDB 115 2e-26 4RED-A nrPDB 114 4e-26 4REW-A nrPDB 114 5e-26 4C0T-A nrPDB 112 2e-25 4UZD-A nrPDB 110 5e-25 5WAX-A nrPDB 110 7e-25 2YCR-A nrPDB 108 3e-24 5XZW-A nrPDB 107 7e-24 3HZT-A nrPDB 106 1e-23 3DXN-A nrPDB 106 1e-23 3I6U-A nrPDB 105 2e-23 2A27-A nrPDB 105 3e-23 3D2K-A nrPDB 103 7e-23 3Q5I-A nrPDB 103 7e-23 3ZUT-A nrPDB 103 9e-23 4PDS-A nrPDB 103 1e-22 2YAB-A nrPDB 102 1e-22 1ZWS-A nrPDB 102 2e-22 3UDB-A nrPDB 102 2e-22 4JXF-A nrPDB 102 2e-22 3LIJ-A nrPDB 102 3e-22 3UC3-A nrPDB 101 4e-22 2JC6-A nrPDB 100 7e-22 5JZN-A nrPDB 100 9e-22 5D9K-A nrPDB 100 2e-21 5DYK-A nrPDB 99 2e-21 2W4O-A nrPDB 98 4e-21 4B8L-A nrPDB 98 4e-21 2J90-A nrPDB 98 4e-21 3DFA-A nrPDB 98 4e-21 3NCG-A nrPDB 98 6e-21 3GUB-A nrPDB 97 7e-21 2VZ6-A nrPDB 97 8e-21 4AF3-A nrPDB 95 3e-20 2JAM-A nrPDB 95 3e-20 3BHH-A nrPDB 95 5e-20 5CEK-A nrPDB 94 6e-20 6DC0-A nrPDB 94 7e-20 5FET-A nrPDB 94 8e-20 2Z7Q-A nrPDB 94 8e-20 4FG9-A nrPDB 94 9e-20 5IG1-A nrPDB 94 1e-19 1PHK-A nrPDB 93 1e-19 5U6Y-A nrPDB 93 2e-19 2Y7J-A nrPDB 93 2e-19 5FG8-A nrPDB 92 2e-19 6BDL-A nrPDB 92 2e-19 4EQM-A nrPDB 92 2e-19 4KRC-A nrPDB 92 2e-19 6FDY-U nrPDB 92 3e-19 6QAU-A nrPDB 92 3e-19 1FOT-A nrPDB 92 3e-19 5JN2-A nrPDB 92 4e-19 4B6L-A nrPDB 92 4e-19 2X4F-A nrPDB 91 5e-19 4I6B-A nrPDB 90 1e-18 4WNO-A nrPDB 90 1e-18 3SOA-A nrPDB 90 1e-18 6CMJ-A nrPDB 89 2e-18 3ORZ-A nrPDB 89 3e-18 1NY3-A nrPDB 89 3e-18 3KN6-A nrPDB 89 3e-18 3MA6-A nrPDB 89 3e-18 3IS5-A nrPDB 89 3e-18 2OZA-A nrPDB 89 3e-18 3F3Z-A nrPDB 88 4e-18 2VN9-A nrPDB 88 6e-18 5N23-A nrPDB 87 1e-17 3KA0-A nrPDB 87 1e-17 3TAC-A nrPDB 86 2e-17 2BRG-A nrPDB 86 2e-17 4RLP-A nrPDB 85 3e-17 4WB7-A nrPDB 85 3e-17 6E2O-A nrPDB 85 3e-17 5X3F-B nrPDB 85 5e-17 5YV8-A nrPDB 84 6e-17 4L42-A nrPDB 84 6e-17 6GVJ-A nrPDB 84 7e-17 1VZO-A nrPDB 84 8e-17 3HMP-A nrPDB 84 1e-16 4RGJ-A nrPDB 83 1e-16 2WTK-C nrPDB 83 2e-16 5AP3-A nrPDB 82 2e-16 2V7O-A nrPDB 82 3e-16 2WQN-A nrPDB 82 3e-16 3FXW-A nrPDB 82 3e-16 4YZB-A nrPDB 82 3e-16 2JDO-A nrPDB 82 4e-16 2ZMD-A nrPDB 82 4e-16 2BDW-A nrPDB 81 5e-16 3KK8-A nrPDB 81 6e-16 3M42-A nrPDB 81 6e-16 5D7A-A nrPDB 80 9e-16 4RA4-A nrPDB 79 2e-15 4TNB-A nrPDB 79 2e-15 2BPM-A nrPDB 79 2e-15 4AGU-A nrPDB 79 2e-15 4AU8-A nrPDB 79 2e-15 3TXO-A nrPDB 79 3e-15 2XNP-A nrPDB 79 3e-15 5O0Y-A nrPDB 79 3e-15 3NIZ-A nrPDB 77 8e-15 6FD3-A nrPDB 77 8e-15 6O6Q-A nrPDB 77 1e-14 1KOA-A nrPDB 77 1e-14 3UTO-A nrPDB 76 1e-14 2F9G-A nrPDB 76 2e-14 5G6V-A nrPDB 76 2e-14 2I0E-A nrPDB 76 2e-14 3PFQ-A nrPDB 76 2e-14 3PVW-A nrPDB 76 2e-14 5UUU-A nrPDB 75 3e-14 4BGQ-A nrPDB 75 3e-14 4FR4-A nrPDB 75 3e-14 3HDN-A nrPDB 75 3e-14 4MYG-A nrPDB 75 3e-14 5LOH-A nrPDB 75 4e-14 3OHT-A nrPDB 75 4e-14 1V0B-A nrPDB 75 4e-14 4QMW-A nrPDB 75 5e-14 5XVU-A nrPDB 75 5e-14 3DB8-A nrPDB 74 6e-14 3GC0-A nrPDB 74 6e-14 5KCV-A nrPDB 74 7e-14 3MV5-A nrPDB 74 7e-14 2F57-A nrPDB 74 8e-14 6ED6-A nrPDB 74 9e-14 3Q53-A nrPDB 74 1e-13 6CCF-A nrPDB 74 1e-13 6DTL-A nrPDB 73 1e-13 2HW6-A nrPDB 73 1e-13 1KOB-A nrPDB 73 1e-13 3GC9-A nrPDB 73 1e-13 1TKI-A nrPDB 73 1e-13 4BBM-A nrPDB 73 1e-13 5AIR-A nrPDB 73 2e-13 6GU6-A nrPDB 73 2e-13 4QNY-A nrPDB 73 2e-13 1UA2-A nrPDB 73 2e-13 4APC-A nrPDB 72 2e-13 3QGY-A nrPDB 72 2e-13 1CM8-A nrPDB 72 2e-13 5F9E-A nrPDB 72 3e-13 4KS7-A nrPDB 72 3e-13 5H2U-A nrPDB 72 3e-13 5EFQ-A nrPDB 72 3e-13 4E7W-A nrPDB 72 3e-13 4XEY-B nrPDB 72 4e-13 6NPU-A nrPDB 72 4e-13 6E9W-A nrPDB 72 4e-13 4NIF-A nrPDB 71 5e-13 4EWQ-A nrPDB 71 5e-13 5DBX-A nrPDB 71 5e-13 2PL0-A nrPDB 71 5e-13 4IAN-A nrPDB 71 6e-13 3A8W-A nrPDB 71 6e-13 4AN9-A nrPDB 71 6e-13 2XIK-A nrPDB 71 6e-13 4CSV-A nrPDB 71 7e-13 3ALO-A nrPDB 71 8e-13 2FO0-A nrPDB 70 9e-13 4NST-A nrPDB 70 1e-12 5Z33-A nrPDB 70 1e-12 4LFI-A nrPDB 70 1e-12 4JG6-A nrPDB 70 1e-12 3NYO-A nrPDB 70 1e-12 6E4F-A nrPDB 70 2e-12 3DAK-A nrPDB 69 2e-12 3ZDU-A nrPDB 69 2e-12 6HMD-A nrPDB 69 2e-12 3E3P-A nrPDB 69 3e-12 4ZSG-A nrPDB 69 3e-12 3E7O-A nrPDB 69 4e-12 4FIE-A nrPDB 69 4e-12 4O2Z-A nrPDB 69 4e-12 4IC8-A nrPDB 69 4e-12 5O2C-A nrPDB 68 4e-12 4JDH-A nrPDB 68 5e-12 4XI2-A nrPDB 68 5e-12 4LG4-A nrPDB 68 5e-12 2Q0N-A nrPDB 68 6e-12 3ORP-A nrPDB 68 6e-12 3COM-A nrPDB 68 6e-12 2XYN-A nrPDB 67 7e-12 5J5T-A nrPDB 67 7e-12 3A4O-X nrPDB 67 7e-12 3HKO-A nrPDB 67 8e-12 6AO5-A nrPDB 67 9e-12 5O2B-A nrPDB 67 9e-12 3FME-A nrPDB 67 9e-12 2HK5-A nrPDB 67 1e-11 4XBR-A nrPDB 67 1e-11 4E93-A nrPDB 67 1e-11 4C59-A nrPDB 67 1e-11 5KKR-C nrPDB 66 2e-11 4MD7-E nrPDB 66 2e-11 3VN9-A nrPDB 66 2e-11 2JD5-A nrPDB 66 2e-11 2I6L-A nrPDB 66 2e-11 6EII-A nrPDB 66 3e-11 2OU7-A nrPDB 66 3e-11 2DQ7-X nrPDB 65 3e-11 3EQC-A nrPDB 65 3e-11 4M7I-A nrPDB 65 3e-11 2XS0-A nrPDB 65 4e-11 5Y86-A nrPDB 65 4e-11 4J52-A nrPDB 65 4e-11 4UY9-A nrPDB 65 4e-11 3LM0-A nrPDB 65 5e-11 4FZF-B nrPDB 65 5e-11 2PMN-X nrPDB 64 6e-11 5NGU-A nrPDB 64 7e-11 1S9I-A nrPDB 64 8e-11 3SV0-A nrPDB 64 9e-11 4U41-A nrPDB 64 9e-11 4AW2-A nrPDB 64 1e-10 3DTC-A nrPDB 64 1e-10 5TE0-A nrPDB 63 1e-10 5B2L-A nrPDB 63 1e-10 4Y93-A nrPDB 63 1e-10 3OZ6-A nrPDB 63 1e-10 5ZTN-A nrPDB 63 2e-10 5VO2-A nrPDB 62 2e-10 3TKU-A nrPDB 62 3e-10 2UV2-A nrPDB 62 3e-10 6FYV-A nrPDB 62 3e-10 4QTB-A nrPDB 62 3e-10 3C51-A nrPDB 62 4e-10 3LMG-A nrPDB 62 4e-10 5X5O-A nrPDB 62 4e-10 1JNK-A nrPDB 62 5e-10 3FI2-A nrPDB 61 5e-10 4PWN-A nrPDB 61 5e-10 3QA8-A nrPDB 61 6e-10 3PG1-A nrPDB 61 6e-10 2H8H-A nrPDB 61 6e-10 5X8I-B nrPDB 60 9e-10 4YHJ-A nrPDB 60 9e-10 2PVN-A nrPDB 60 9e-10 3NIE-A nrPDB 60 1e-09 6F3F-A nrPDB 60 1e-09 5IKW-A nrPDB 60 1e-09 5SYS-A nrPDB 60 1e-09 3EB0-A nrPDB 60 1e-09 3N9X-A nrPDB 60 2e-09 5AWM-A nrPDB 59 2e-09 6HXF-B nrPDB 59 3e-09 4OW8-A nrPDB 59 4e-09 3SXS-A nrPDB 59 4e-09 4X3F-A nrPDB 59 4e-09 6B2Q-A nrPDB 58 5e-09 3UIM-A nrPDB 58 6e-09 5HIE-A nrPDB 58 6e-09 5TQX-A nrPDB 58 7e-09 4H1J-A nrPDB 57 7e-09 6BXI-A nrPDB 57 7e-09 5L2Q-C nrPDB 57 8e-09 3DKO-A nrPDB 57 8e-09 3UIU-A nrPDB 57 9e-09 5LPZ-A nrPDB 57 9e-09 5LPV-A nrPDB 57 9e-09 3PP0-A nrPDB 57 1e-08 4PDO-A nrPDB 57 1e-08 1U5R-A nrPDB 57 1e-08 5FQD-C nrPDB 57 1e-08 2R2P-A nrPDB 56 2e-08 1ZXE-A nrPDB 56 2e-08 2GCD-A nrPDB 56 2e-08 4KIK-B nrPDB 56 2e-08 1G3N-A nrPDB 55 4e-08 6CTH-A nrPDB 55 4e-08 4LRM-A nrPDB 55 4e-08 3LZB-A nrPDB 55 4e-08 5HI2-A nrPDB 55 5e-08 2WO6-A nrPDB 55 5e-08 3RP9-A nrPDB 55 5e-08 4UYA-A nrPDB 55 5e-08 4TN6-A nrPDB 54 7e-08 2VD5-A nrPDB 54 7e-08 4P5Q-A nrPDB 54 1e-07 4CRL-A nrPDB 54 1e-07 6CKI-A nrPDB 53 2e-07 3BBT-B nrPDB 53 2e-07 1AD5-A nrPDB 53 2e-07 5GNK-A nrPDB 53 2e-07 4IDT-A nrPDB 52 3e-07 2W96-B nrPDB 52 3e-07 4OTD-A nrPDB 52 4e-07 3RAW-A nrPDB 52 4e-07 5UNP-A nrPDB 52 4e-07 4GS6-A nrPDB 51 6e-07 4Y83-A nrPDB 51 6e-07 5AMN-A nrPDB 51 6e-07 5FM2-A nrPDB 51 7e-07 4XHH-A nrPDB 51 7e-07 4BTK-A nrPDB 51 7e-07 4EBW-A nrPDB 51 8e-07 4NFN-A nrPDB 50 9e-07 4F9B-A nrPDB 50 9e-07 3QD2-B nrPDB 50 1e-06 4MWI-A nrPDB 50 1e-06 4LQP-A nrPDB 50 1e-06 6DBM-A nrPDB 50 1e-06 1CSN-A nrPDB 50 1e-06 5HLW-A nrPDB 50 1e-06 4XHL-A nrPDB 50 1e-06 4JRN-A nrPDB 50 1e-06 1LUF-A nrPDB 50 2e-06 6GQK-A nrPDB 49 2e-06 3CJF-A nrPDB 49 2e-06 3PPZ-A nrPDB 49 2e-06 3VHK-A nrPDB 49 3e-06 2J0K-A nrPDB 49 3e-06 3OMV-A nrPDB 49 3e-06 2Y6O-A nrPDB 49 3e-06 4OLI-A nrPDB 49 4e-06 4YFF-A nrPDB 49 4e-06 4IX6-A nrPDB 49 4e-06 6J5U-C nrPDB 49 4e-06 3C1X-A nrPDB 48 4e-06 5TOS-A nrPDB 48 5e-06 4HVI-A nrPDB 48 6e-06 5WNL-A nrPDB 48 6e-06 4K33-A nrPDB 47 8e-06 4JLC-A nrPDB 47 9e-06 1K9A-A nrPDB 47 9e-06 5EG3-A nrPDB 47 1e-05 1U59-A nrPDB 47 1e-05 6CQF-A nrPDB 47 1e-05 4G3E-A nrPDB 47 1e-05 6O8B-A nrPDB 47 1e-05 4EUT-A nrPDB 47 1e-05 1JPA-A nrPDB 46 2e-05 5WNO-A nrPDB 46 2e-05 4EUU-A nrPDB 46 2e-05 4CRS-A nrPDB 46 2e-05 6NT9-A nrPDB 46 2e-05 3MIA-A nrPDB 46 2e-05 1BYG-A nrPDB 46 2e-05 2Y4I-B nrPDB 46 3e-05 4XCU-A nrPDB 45 3e-05 2H34-A nrPDB 45 3e-05 3TT0-A nrPDB 45 3e-05 5A46-A nrPDB 45 3e-05 3LLT-A nrPDB 45 3e-05 2OZO-A nrPDB 45 3e-05 3PLS-A nrPDB 45 4e-05 3GQL-A nrPDB 45 4e-05 2PSQ-A nrPDB 45 4e-05 5VD3-A nrPDB 45 4e-05 4NEU-A nrPDB 45 5e-05 4M69-B nrPDB 45 5e-05 4BTF-A nrPDB 44 6e-05 5X18-A nrPDB 44 7e-05 2CMW-A nrPDB 44 7e-05 4F0G-A nrPDB 44 7e-05 3BYV-A nrPDB 44 8e-05 1FVR-A nrPDB 44 8e-05 4FL3-A nrPDB 44 8e-05 4E20-A nrPDB 44 9e-05 2OGV-A nrPDB 44 1e-04 2RIO-A nrPDB 44 1e-04 5C26-A nrPDB 43 1e-04 5MJB-A nrPDB 43 1e-04 2QKW-B nrPDB 43 1e-04 5U6B-A nrPDB 43 1e-04 3HNG-A nrPDB 43 1e-04 4XLV-A nrPDB 43 2e-04 3KUL-B nrPDB 43 2e-04 3BEA-A nrPDB 43 2e-04 5XD6-A nrPDB 42 3e-04 4R7H-A nrPDB 42 3e-04 5X1R-A nrPDB 42 3e-04 3KRL-A nrPDB 42 3e-04 3G0E-A nrPDB 42 3e-04 2CHL-A nrPDB 42 3e-04 6EQI-C nrPDB 42 3e-04 5L6P-A nrPDB 42 4e-04 4Y12-A nrPDB 42 5e-04 2PZI-A nrPDB 42 5e-04 4AT3-A nrPDB 42 5e-04 2BUJ-A nrPDB 41 5e-04 4M66-A nrPDB 41 5e-04 5GRN-A nrPDB 41 6e-04 5UIU-A nrPDB 41 8e-04 2C47-A nrPDB 40 0.001 2VWV-A nrPDB 40 0.001 5VC6-A nrPDB 40 0.002 2W1Z-A nrPDB 39 0.002 5CLR-A nrPDB 39 0.003 4NT4-A nrPDB 39 0.004 2WTK-B nrPDB 38 0.005 5OAT-A nrPDB 38 0.006 5VDK-A nrPDB 38 0.006 3I81-A nrPDB 38 0.006 4TPT-A nrPDB 38 0.006 3ZBF-A nrPDB 38 0.006 3DZO-A nrPDB 38 0.007 4O1O-A nrPDB 37 0.008 6HV0-A nrPDB 37 0.009 5AR8-A nrPDB 37 0.009 5DMZ-A nrPDB 37 0.010 3REP-A nrPDB 36 0.021 3MDY-A nrPDB 36 0.023 4XUF-A nrPDB 36 0.026 5X02-A nrPDB 36 0.027 4OAU-C nrPDB 35 0.030 5J0A-A nrPDB 35 0.034 5USZ-A nrPDB 35 0.058 2LAV-A nrPDB 35 0.060 2W1I-A nrPDB 35 0.060 3IO7-A nrPDB 34 0.064 4CI6-B nrPDB 34 0.071 4RT7-A nrPDB 34 0.079 2RSV-A nrPDB 34 0.090 1U54-B nrPDB 34 0.096 4HZS-A nrPDB 33 0.13 4PL5-B nrPDB 33 0.18 5ORE-A nrPDB 32 0.28 5E8V-A nrPDB 32 0.42 4WUA-A nrPDB 32 0.43 3SOC-A nrPDB 31 0.78 5VE6-A nrPDB 30 1.2 2X7G-A nrPDB 30 1.2 1PY5-A nrPDB 29 3.0 3Q4U-A nrPDB 29 3.0 6BFN-A nrPDB 28 3.5 3MY0-A nrPDB 28 4.4 6EWX-A nrPDB 27 7.6 2Z01-A nrPDB 27 8.1 6G4J-A nrPDB 27 9.2 >5TUR-A nrPDB Length = 404 Score = 644 bits (1662), Expect = 0.0, Method: Compositional matrix adjust. Identities = 313/313 (100%), Positives = 313/313 (100%) Query: 1 MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD 60 MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD Sbjct: 92 MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD 151 Query: 61 NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL 120 NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL Sbjct: 152 NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL 211 Query: 121 ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG 180 ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG Sbjct: 212 ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG 271 Query: 181 ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI 240 ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI Sbjct: 272 ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI 331 Query: 241 PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA 300 PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA Sbjct: 332 PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA 391 Query: 301 EIHLHSLSPGPSK 313 EIHLHSLSPGPSK Sbjct: 392 EIHLHSLSPGPSK 404 >3BGP-A nrPDB Length = 333 Score = 643 bits (1658), Expect = 0.0, Method: Compositional matrix adjust. Identities = 313/313 (100%), Positives = 313/313 (100%) Query: 1 MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD 60 MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD Sbjct: 21 MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD 80 Query: 61 NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL 120 NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL Sbjct: 81 NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL 140 Query: 121 ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG 180 ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG Sbjct: 141 ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG 200 Query: 181 ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI 240 ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI Sbjct: 201 ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI 260 Query: 241 PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA 300 PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA Sbjct: 261 PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA 320 Query: 301 EIHLHSLSPGPSK 313 EIHLHSLSPGPSK Sbjct: 321 EIHLHSLSPGPSK 333 >4RC3-A nrPDB Length = 289 Score = 585 bits (1508), Expect = e-168, Method: Compositional matrix adjust. Identities = 285/285 (100%), Positives = 285/285 (100%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM Sbjct: 5 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 64 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 148 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF Sbjct: 65 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 124 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYS 208 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYS Sbjct: 125 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYS 184 Query: 209 PPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIR 268 PPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIR Sbjct: 185 PPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIR 244 Query: 269 WCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK 313 WCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK Sbjct: 245 WCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK 289 >4X7Q-B nrPDB Length = 312 Score = 333 bits (854), Expect = 6e-92, Method: Compositional matrix adjust. Identities = 166/285 (58%), Positives = 205/285 (71%), Gaps = 5/285 (1%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 K++E E++Y++GPLLG GGFG+V++G R++D L VAIK + ++R+ W L + P+ Sbjct: 24 KDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPL 83 Query: 89 EVVLLKKVSSG--FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARS 146 EV LL KV +G GVIRLLDWFE + F+L+LERP P QDLFD+ITE+G L E +R Sbjct: 84 EVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRC 143 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV 206 FF QV+ A++HCH+ GV+HRDIKDENILIDL RG KLIDFGSGALL D YTDFDGTRV Sbjct: 144 FFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRV 203 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHL 266 YSPPEWI H+YH A VWSLGILLYDMVCGDIPFE D+EI+ ++ F VS +C L Sbjct: 204 YSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCAL 263 Query: 267 IRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGP 311 IR CLA +PS RP+ EEI PWMQ P E ++ P P Sbjct: 264 IRRCLAPKPSSRPSLEEILLDPWMQT---PAEDVPLNPSKGGPAP 305 >3DLS-A nrPDB Length = 335 Score = 140 bits (352), Expect = 8e-34, Method: Compositional matrix adjust. Identities = 89/257 (34%), Positives = 135/257 (52%), Gaps = 6/257 (2%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISD--WGELPNGTRVPMEVVLLK 94 +Y LGSG FG V++ + N V +K ++K+++ + W E P +V +E+ +L Sbjct: 25 KYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEIAILS 84 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 +V + +I++LD FE F L++E+ DLF FI L E LA F Q++ A Sbjct: 85 RVEH--ANIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQLVSA 142 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL-KDTVYTDFDGTRVYSPPEWI 213 V + ++HRDIKDENI+I + +KLIDFGS A L + ++ F GT Y PE + Sbjct: 143 VGYLRLKDIIHRDIKDENIVIAEDF-TIKLIDFGSAAYLERGKLFYTFCGTIEYCAPEVL 201 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLAL 273 + Y G +WSLG+ LY +V + PF EE + + VS E L+ L Sbjct: 202 MGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSGLLQP 261 Query: 274 RPSDRPTFEEIQNHPWM 290 P R T E++ PW+ Sbjct: 262 VPERRTTLEKLVTDPWV 278 >4YNZ-A nrPDB Length = 342 Score = 138 bits (348), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 90/269 (33%), Positives = 143/269 (53%), Gaps = 20/269 (7%) Query: 33 PLESQYQVGPL-----LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 PL S VGP LG G G V GI VAIK V ++++S+ + +V Sbjct: 2 PLGSMQYVGPYRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLM----KVE 57 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSF 147 E+ +LK + V++L D +E L+LE +LFD++ ++G L + AR F Sbjct: 58 REIAILKLIEH--PHVLKLHDVYENKKYLYLVLEHVSG-GELFDYLVKKGRLTPKEARKF 114 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL-LKDTVYTDFDGTRV 206 F Q++ A+ CH+ + HRD+K EN+L+D R +++ DFG +L + D++ G+ Sbjct: 115 FRQIISALDFCHSHSICHRDLKPENLLLD-ERNNIRIADFGMASLQVGDSLLETSCGSPH 173 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVS 260 Y+ PE IR +Y GR A VWS G++L+ ++ G +PF+ D E++ RG + Sbjct: 174 YACPEVIRGEKYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIP 233 Query: 261 SECQHLIRWCLALRPSDRPTFEEIQNHPW 289 +CQ L+R + + + R T E IQ H W Sbjct: 234 PDCQSLLRGMIEVDAARRLTLEHIQKHIW 262 >4CQG-A nrPDB Length = 331 Score = 135 bits (339), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 98/280 (35%), Positives = 145/280 (51%), Gaps = 19/280 (6%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 K+ + L Y++ +G+GGF V V VAIK ++K+ + +LP RV Sbjct: 2 KDYDELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALG--SDLP---RVKT 56 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 148 E+ LK + + +L E + ++LE P +LFD+I + L EE R F Sbjct: 57 EIDALKSLRH--QHICQLYHVLETKNKIFMVLEYC-PGGELFDYIISQDRLSEEETRVVF 113 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL---LKDTVYTDFDGTR 205 Q+L AV + H+ G HRD+K EN+L D N +LKLIDFG A KD + G+ Sbjct: 114 RQILSAVAYVHSQGYAHRDLKPENLLFDENH-KLKLIDFGLCAKPKGNKDYHLQECCGSL 172 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRV 259 Y+ PE I+ Y G A VWS+GILLY ++CG +PF+ D ++I+RG+ + + Sbjct: 173 AYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWL 232 Query: 260 SSECQHLIRWCLALRPSDRPTFEEIQNHPW-MQDVLLPQE 298 S L++ L + P R + + NHPW MQD P E Sbjct: 233 SPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSCPVE 272 >4MVF-A nrPDB Length = 506 Score = 129 bits (325), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 88/282 (31%), Positives = 142/282 (50%), Gaps = 24/282 (8%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 LE +Y + LG G +G VY GI N AIK +KDR L N R E+ ++ Sbjct: 55 LEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDR------LKNINRFFQEIEIM 108 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 KK+ +++L + +E + LI+E ++LFD I E G+ E+ A + Q+ Sbjct: 109 KKLDH--PNIVKLYETYENDNYIYLIMELCSG-RELFDSIIENGSFTEKNAATIMKQIFS 165 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRGE--LKLIDFG-SGALLKDTVYTDFDGTRVYSPP 210 A+ + H+ ++HRD+K EN L + LK+IDFG S L T GT Y P Sbjct: 166 AIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVAP 225 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHDEEII----RGQVFFRQR----VS 260 + + + + +WS G+++Y ++CG PF + D E++ +G+ F + +S Sbjct: 226 QVL--DGKYDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSIS 283 Query: 261 SECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEI 302 S+ ++LI L P++R T EE NHPW+ + E E+ Sbjct: 284 SDAKNLITKLLTYNPNERCTIEEALNHPWITQMTKSHEHVEL 325 >5KZ7-A nrPDB Length = 346 Score = 129 bits (325), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 78/273 (28%), Positives = 144/273 (52%), Gaps = 15/273 (5%) Query: 26 APGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTR 85 A +++P Y++ +G G F V + VA+K ++K +++ + + Sbjct: 23 ATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNS----SSLQK 78 Query: 86 VPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELAR 145 + EV ++K ++ +++L + E + L++E ++FD++ G ++E+ AR Sbjct: 79 LFREVRIMKVLNH--PNIVKLFEVIETEKTLYLVMEYASG-GEVFDYLVAHGRMKEKEAR 135 Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDGT 204 + F Q++ AV++CH ++HRD+K EN+L+D + +K+ DFG S F G+ Sbjct: 136 AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMN-IKIADFGFSNEFTFGNKLDTFCGS 194 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF------EHDEEIIRGQVFFRQR 258 Y+ PE + +Y G VWSLG++LY +V G +PF E E ++RG+ Sbjct: 195 PPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFY 254 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 +S++C++L++ L L PS R T E+I WM Sbjct: 255 MSTDCENLLKKFLILNPSKRGTLEQIMKDRWMN 287 >4D2V-A nrPDB Length = 356 Score = 129 bits (325), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 94/280 (33%), Positives = 142/280 (50%), Gaps = 19/280 (6%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 K+ + L Y++ +G+GGF V + VAIK ++K+ + +LP R+ Sbjct: 22 KDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLG--SDLP---RIKT 76 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 148 E+ LK + + +L E + ++LE P +LFD+I + L EE R F Sbjct: 77 EIEALKNLRH--QHICQLYHVLETANKIFMVLEYC-PGGELFDYIISQDRLSEEETRVVF 133 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL---LKDTVYTDFDGTR 205 Q++ AV + H+ G HRD+K EN+L D +LKLIDFG A KD G Sbjct: 134 RQIVSAVAYVHSQGYAHRDLKPENLLFD-EYHKLKLIDFGLCAKPKGNKDYHLQACCGAL 192 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EIIRGQVFFRQRV 259 Y+ PE I+ Y G A VWS+GILLY ++CG +PF+ D +I+RG+ + + Sbjct: 193 AYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWL 252 Query: 260 SSECQHLIRWCLALRPSDRPTFEEIQNHPW-MQDVLLPQE 298 S L++ L + P R + + + NHPW MQD P E Sbjct: 253 SPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVE 292 >5ES1-A nrPDB Length = 328 Score = 129 bits (324), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 78/278 (28%), Positives = 144/278 (51%), Gaps = 17/278 (6%) Query: 22 ATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELP 81 +A E++P Y++ +G G F V + VAIK ++K +++ P Sbjct: 1 GNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN-----P 55 Query: 82 NG-TRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQ 140 + ++ EV ++K ++ +++L + E + L++E ++FD++ G ++ Sbjct: 56 SSLQKLFREVRIMKGLNH--PNIVKLFEVIETEKTLYLVMEYA-SAGEVFDYLVSHGRMK 112 Query: 141 EELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYT 199 E+ AR+ F Q++ AV +CH ++HRD+K EN+L+D +K+ DFG S + Sbjct: 113 EKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAE-ANIKIADFGFSNEFTLGSKLD 171 Query: 200 DFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF------EHDEEIIRGQV 253 F G+ Y+ PE + +Y G +WSLG++LY +V G +PF E E ++RG+ Sbjct: 172 TFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKY 231 Query: 254 FFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 +S++C+ ++R L L P+ R T E+I W+ Sbjct: 232 RVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWIN 269 >2QNJ-A nrPDB Length = 328 Score = 129 bits (324), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 80/273 (29%), Positives = 141/273 (51%), Gaps = 15/273 (5%) Query: 26 APGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTR 85 A G +++P Y++ +G G F V + VAIK ++K +++ P + Sbjct: 2 AMGSDEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLN-----PTSLQ 56 Query: 86 VPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELAR 145 V + K+ + +++L + E + LI+E ++FD++ G ++E+ AR Sbjct: 57 KLFREVRIMKILN-HPNIVKLFEVIETEKTLYLIMEYASG-GEVFDYLVAHGRMKEKEAR 114 Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDGT 204 S F Q++ AV++CH ++HRD+K EN+L+D + +K+ DFG S F G+ Sbjct: 115 SKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMN-IKIADFGFSNEFTVGGKLDTFCGS 173 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF------EHDEEIIRGQVFFRQR 258 Y+ PE + +Y G VWSLG++LY +V G +PF E E ++RG+ Sbjct: 174 PPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFY 233 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 +S++C++L++ L L P R T E+I W+ Sbjct: 234 MSTDCENLLKRFLVLNPIKRGTLEQIMKDRWIN 266 >5YKS-A nrPDB Length = 377 Score = 129 bits (323), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 88/264 (33%), Positives = 133/264 (50%), Gaps = 15/264 (5%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 Y + LG G F V V VA+K ++K ++ L G + EV +K V Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLD---TLATG-HLFQEVRCMKLVQ 92 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSFFWQVLEAVR 156 ++RL + + LILE + D+FD+I + L E+LA+ +F Q++ A+ Sbjct: 93 H--PNIVRLYEVIDTQTKLYLILELGDG-GDMFDYIMKHEEGLNEDLAKKYFAQIVHAIS 149 Query: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIRY 215 +CH V+HRD+K EN++ +G +KL DFG S T G+ YS PE + Sbjct: 150 YCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLG 209 Query: 216 HRYHGRSAAVWSLGILLYDMVCGDIPFE--HDEE----IIRGQVFFRQRVSSECQHLIRW 269 Y + +WSLG++L+ +VCG PF+ +D E I+ + VS EC+ LI Sbjct: 210 DEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITR 269 Query: 270 CLALRPSDRPTFEEIQNHPWMQDV 293 L P R + EEI+NHPW+Q V Sbjct: 270 MLQRDPKRRASLEEIENHPWLQGV 293 >4CZT-A nrPDB Length = 464 Score = 124 bits (312), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 85/267 (31%), Positives = 135/267 (50%), Gaps = 21/267 (7%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNG--TRVPMEVVLLK 94 +Y++G LG G F V V + VAIK ++K+++ L N ++ E+ +K Sbjct: 12 KYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKV-----LKNKMIAQIKREISTMK 66 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 + VIR+ + +LE +LFD I+ G L+E+ AR +F Q++ A Sbjct: 67 LIKH--PNVIRMFEVMASKTKIYFVLEFVTG-GELFDKISSNGRLKEDEARKYFQQLINA 123 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL----LKDTVYTDFDGTRVYSPP 210 V +CH+ GV HRD+K EN+L+D N G LK+ DFG AL +D + GT Y P Sbjct: 124 VDYCHSRGVYHRDLKPENLLLDAN-GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAP 182 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQ 264 E I Y G A +WS G++L+ ++ G +PFE ++I + + S+ + Sbjct: 183 EVINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAK 242 Query: 265 HLIRWCLALRPSDRPTFEEIQNHPWMQ 291 LI+ L P+ R TF E+ + W + Sbjct: 243 KLIKRILDPNPATRITFAEVIENEWFK 269 >2YZA-A nrPDB Length = 276 Score = 121 bits (303), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 82/267 (30%), Positives = 131/267 (49%), Gaps = 16/267 (5%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 Y +G LG G FG V G VA+K + + +I + R + L + Sbjct: 11 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH 70 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 +I+L P F +++E +LFD+I + G ++E AR F Q+L AV Sbjct: 71 -----PHIIKLYQVISTPTDFFMVMEYVSG-GELFDYICKHGRVEEMEARRLFQQILSAV 124 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT-DFDGTRVYSPPEWIR 214 +CH V+HRD+K EN+L+D + K+ DFG ++ D + D G+ Y+ PE I Sbjct: 125 DYCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRDSCGSPNYAAPEVIS 183 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEI------IRGQVFF-RQRVSSECQHLI 267 Y G +WS G++LY ++CG +PF+ DE + IRG VF+ + ++ L+ Sbjct: 184 GRLYAGPEVDIWSCGVILYALLCGTLPFD-DEHVPTLFKKIRGGVFYIPEYLNRSVATLL 242 Query: 268 RWCLALRPSDRPTFEEIQNHPWMQDVL 294 L + P R T ++I+ H W + L Sbjct: 243 MHMLQVDPLKRATIKDIREHEWFKQDL 269 >4CFF-A nrPDB Length = 571 Score = 119 bits (299), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 81/266 (30%), Positives = 130/266 (48%), Gaps = 16/266 (6%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 Y +G LG G FG V G VA+K + + +I + R + L + Sbjct: 34 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH- 92 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156 +I+L P F +++E +LFD+I + G ++E AR F Q+L AV Sbjct: 93 ----PHIIKLYQVISTPTDFFMVMEYVSG-GELFDYICKHGRVEEMEARRLFQQILSAVD 147 Query: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD-GTRVYSPPEWIRY 215 +CH V+HRD+K EN+L+D + K+ DFG ++ D + G+ Y+ PE I Sbjct: 148 YCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 206 Query: 216 HRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEI------IRGQVFF-RQRVSSECQHLIR 268 Y G +WS G++LY ++CG +PF+ DE + IRG VF+ + ++ L+ Sbjct: 207 RLYAGPEVDIWSCGVILYALLCGTLPFD-DEHVPTLFKKIRGGVFYIPEYLNRSVATLLM 265 Query: 269 WCLALRPSDRPTFEEIQNHPWMQDVL 294 L + P R T ++I+ H W + L Sbjct: 266 HMLQVDPLKRATIKDIREHEWFKQDL 291 >4D28-A nrPDB Length = 446 Score = 119 bits (299), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 88/284 (30%), Positives = 140/284 (49%), Gaps = 22/284 (7%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT--RVPMEVVLLK 94 +Y+VG +G G F V VAIK + K I L N ++ E+ ++K Sbjct: 10 KYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTI-----LKNRMVDQIKREISIMK 64 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 V ++RL + ++LE +LFD I +G L+E+ +R +F Q+++A Sbjct: 65 IVRH--PNIVRLYEVLASKSKIYIVLEFVTG-GELFDRIVHKGRLKEDESRKYFQQLVDA 121 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEW 212 V HCH+ GV HRD+K EN+L+D N G LK+ DFG AL ++ V D GT Y PE Sbjct: 122 VAHCHSKGVYHRDLKPENLLLDTN-GNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEV 180 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EIIRGQVFFRQRVSSECQHL 266 + Y G +A +WS G++L+ ++ G +PF + +I + S+E + L Sbjct: 181 LSGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFDCPPWFSAEVKFL 240 Query: 267 IRWCLALRPSDRPTFEEIQNHPWMQDVLLP---QETAEIHLHSL 307 I L P R + I+ PW + +P +E E++L + Sbjct: 241 IHRILDPNPKTRIQIQGIKKDPWFRKNYVPIRAREEEEVNLDDI 284 >5EZV-A nrPDB Length = 560 Score = 119 bits (299), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 81/266 (30%), Positives = 130/266 (48%), Gaps = 16/266 (6%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 Y +G LG G FG V G VA+K + + +I + R + L + Sbjct: 29 HYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRH- 87 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156 +I+L P F +++E +LFD+I + G ++E AR F Q+L AV Sbjct: 88 ----PHIIKLYQVISTPTDFFMVMEYVSG-GELFDYICKHGRVEEMEARRLFQQILSAVD 142 Query: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD-GTRVYSPPEWIRY 215 +CH V+HRD+K EN+L+D + K+ DFG ++ D + G+ Y+ PE I Sbjct: 143 YCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 201 Query: 216 HRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEI------IRGQVFF-RQRVSSECQHLIR 268 Y G +WS G++LY ++CG +PF+ DE + IRG VF+ + ++ L+ Sbjct: 202 RLYAGPEVDIWSCGVILYALLCGTLPFD-DEHVPTLFKKIRGGVFYIPEYLNRSVATLLM 260 Query: 269 WCLALRPSDRPTFEEIQNHPWMQDVL 294 L + P R T ++I+ H W + L Sbjct: 261 HMLQVDPLKRATIKDIREHEWFKQDL 286 >3MN3-A nrPDB Length = 271 Score = 118 bits (295), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 79/268 (29%), Positives = 131/268 (48%), Gaps = 16/268 (5%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 YQ+ LG G FG V + VA+K + K ++ R+ E+ L+ + Sbjct: 5 NYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSDM---QGRIEREISYLRLL 61 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156 +I+L D + D ++++E +LFD+I +R + E+ AR FF Q++ AV Sbjct: 62 RH--PHIIKLYDVIKSKDEIIMVIEYAG--NELFDYIVQRDKMSEQEARRFFQQIISAVE 117 Query: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD-GTRVYSPPEWIRY 215 +CH ++HRD+K EN+L+D +K+ DFG ++ D + G+ Y+ PE I Sbjct: 118 YCHRHKIVHRDLKPENLLLD-EHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISG 176 Query: 216 HRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRW 269 Y G VWS G++LY M+C +PF+ + + I G + +S LI+ Sbjct: 177 KLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIKR 236 Query: 270 CLALRPSDRPTFEEIQNHPWMQDVLLPQ 297 L + P +R + EI W + V LP+ Sbjct: 237 MLIVNPLNRISIHEIMQDDWFK-VDLPE 263 >3H4J-B nrPDB Length = 336 Score = 117 bits (293), Expect = 7e-27, Method: Compositional matrix adjust. Identities = 90/288 (31%), Positives = 135/288 (46%), Gaps = 36/288 (12%) Query: 36 SQYQVGPL-----LGSGGFGSVYSGIRVSDNLPVAIKHVEKD--RISDWGELPNGTRVPM 88 S+ +GP LG G FG V VA+K + + + SD RV Sbjct: 4 SKRHIGPYIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSDMH-----MRVER 58 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 148 E+ LK + +I+L D P V+++E +LFD+I E+ + E+ R FF Sbjct: 59 EISYLKLLRH--PHIIKLYDVITTPTDIVMVIEYAG--GELFDYIVEKKRMTEDEGRRFF 114 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD-GTRVY 207 Q++ A+ +CH ++HRD+K EN+L+D N +K+ DFG ++ D + G+ Y Sbjct: 115 QQIICAIEYCHRHKIVHRDLKPENLLLDDNLN-VKIADFGLSNIMTDGNFLKTSCGSPNY 173 Query: 208 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR--------- 258 + PE I Y G VWS GI+LY M+ G +PF D+E I F++ Sbjct: 174 AAPEVINGKLYAGPEVDVWSCGIVLYVMLVGRLPF--DDEFIPN--LFKKVNSCVYVMPD 229 Query: 259 -VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ----DVLLPQETAE 301 +S Q LIR + P R T +EI+ PW D L P E + Sbjct: 230 FLSPGAQSLIRRMIVADPMQRITIQEIRRDPWFNVNLPDYLRPMEEVQ 277 >6C9D-A nrPDB Length = 459 Score = 116 bits (291), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 76/274 (27%), Positives = 141/274 (51%), Gaps = 15/274 (5%) Query: 25 LAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 84 + +++P Y++ +G G F V V VA+K ++K +++ P Sbjct: 10 ITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLN-----PTSL 64 Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELA 144 + V + K+ + +++L + E + L++E ++FD++ G ++E+ A Sbjct: 65 QKLFREVRIMKILN-HPNIVKLFEVIETEKTLYLVMEYASG-GEVFDYLVAHGRMKEKEA 122 Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDG 203 R+ F Q++ AV++CH ++HRD+K EN+L+D + +K+ DFG S +F G Sbjct: 123 RAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMN-IKIADFGFSNEFTVGNKLDEFCG 181 Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF------EHDEEIIRGQVFFRQ 257 + Y+ PE + +Y G VWSLG++LY +V G +PF E E ++RG+ Sbjct: 182 SPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPF 241 Query: 258 RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 +S++C++L++ L L P R + E+I WM Sbjct: 242 YMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMN 275 >2HAK-A nrPDB Length = 328 Score = 115 bits (289), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 76/277 (27%), Positives = 140/277 (50%), Gaps = 15/277 (5%) Query: 22 ATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELP 81 + +++P Y++ +G G F V V VA+K ++K +++ P Sbjct: 1 GNSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLN-----P 55 Query: 82 NGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQE 141 + V + K+ + +++L + E + L++E ++FD++ G ++E Sbjct: 56 TSLQKLFREVRIMKILN-HPNIVKLFEVIETEKTLYLVMEYASG-GEVFDYLVAHGRMKE 113 Query: 142 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTD 200 + AR+ F Q++ AV++CH ++HRD+K EN+L+D + +K+ DFG S Sbjct: 114 KEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMN-IKIADFGFSNEFTVGNKLDT 172 Query: 201 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF------EHDEEIIRGQVF 254 F G+ Y+ PE + +Y G VWSLG++LY +V G +PF E E ++RG+ Sbjct: 173 FCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYR 232 Query: 255 FRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 +S++C++L++ L L P R + E+I WM Sbjct: 233 IPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMN 269 >4CFH-A nrPDB Length = 493 Score = 115 bits (288), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 76/265 (28%), Positives = 126/265 (47%), Gaps = 14/265 (5%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 Y +G LG G FG V G VA+K + + +I + R + L + Sbjct: 34 HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH- 92 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156 +I+L P +++E +LFD+I + G L E+ +R F Q+L V Sbjct: 93 ----PHIIKLYQVISTPSDIFMVMEYVSG-GELFDYICKNGRLDEKESRRLFQQILSGVD 147 Query: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD-GTRVYSPPEWIRY 215 +CH V+HRD+K EN+L+D + K+ DFG ++ D + G+ Y+ PE I Sbjct: 148 YCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 206 Query: 216 HRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRW 269 Y G +WS G++LY ++CG +PF+ D ++I G + Q ++ L++ Sbjct: 207 RLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKH 266 Query: 270 CLALRPSDRPTFEEIQNHPWMQDVL 294 L + P R T ++I+ H W + L Sbjct: 267 MLQVDPMKRATIKDIREHEWFKQDL 291 >4RED-A nrPDB Length = 351 Score = 114 bits (286), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 74/262 (28%), Positives = 125/262 (47%), Gaps = 14/262 (5%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 Y +G LG G FG V G VA+K + + +I + R + L + Sbjct: 15 HYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH- 73 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156 +I+L P +++E +LFD+I + G L E+ +R F Q+L V Sbjct: 74 ----PHIIKLYQVISTPSDIFMVMEYVSG-GELFDYICKNGRLDEKESRRLFQQILSGVD 128 Query: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD-GTRVYSPPEWIRY 215 +CH V+HRD+K EN+L+D + K+ DFG ++ D + G+ Y+ PE I Sbjct: 129 YCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 187 Query: 216 HRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRW 269 Y G +WS G++LY ++CG +PF+ D ++I G + Q ++ L++ Sbjct: 188 RLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKH 247 Query: 270 CLALRPSDRPTFEEIQNHPWMQ 291 L + P R + ++I+ H W + Sbjct: 248 MLQVDPMKRASIKDIREHEWFK 269 >4REW-A nrPDB Length = 540 Score = 114 bits (286), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 75/265 (28%), Positives = 126/265 (47%), Gaps = 14/265 (5%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 Y +G LG G FG V G VA+K + + +I + R + L + Sbjct: 7 HYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRH- 65 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156 +I+L P +++E +LFD+I + G L E+ +R F Q+L V Sbjct: 66 ----PHIIKLYQVISTPSDIFMVMEYVSG-GELFDYICKNGRLDEKESRRLFQQILSGVD 120 Query: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD-GTRVYSPPEWIRY 215 +CH V+HRD+K EN+L+D + K+ DFG ++ D + G+ Y+ PE I Sbjct: 121 YCHRHMVVHRDLKPENVLLDAHMNA-KIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISG 179 Query: 216 HRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRW 269 Y G +WS G++LY ++CG +PF+ D ++I G + Q ++ L++ Sbjct: 180 RLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKH 239 Query: 270 CLALRPSDRPTFEEIQNHPWMQDVL 294 L + P R + ++I+ H W + L Sbjct: 240 MLQVDPMKRASIKDIREHEWFKQDL 264 >4C0T-A nrPDB Length = 974 Score = 112 bits (280), Expect = 2e-25, Method: Composition-based stats. Identities = 83/275 (30%), Positives = 132/275 (48%), Gaps = 24/275 (8%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 + ++ G LG G + +V A+K ++K I ++ V +E L + Sbjct: 266 TDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKV---KYVNIEKHALNR 322 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 +S+ GVI L F+ DS +L+ +L I L EE R F Q+L+A+ Sbjct: 323 LSNRL-GVISLYFTFQDKDSLYFVLDYASN-GELLTLIKRYNTLNEECTRHFGAQILDAI 380 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-----------DTVYTDFDGT 204 ++ H+ GV+HRD+K ENIL+D ++ +++ DFG+ LL+ D F GT Sbjct: 381 KYMHDNGVIHRDLKPENILLD-DKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGT 439 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQR 258 Y PE + ++Y G+ VW+ G ++Y M+ G PF+ E I + Q F Sbjct: 440 AEYVSPELLE-NKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFSAG 498 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 + + LI+ L L+PS R T EIQ H + Q V Sbjct: 499 FPTIIRDLIKKILVLQPSRRATIPEIQKHYFFQSV 533 >4UZD-A nrPDB Length = 287 Score = 110 bits (276), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 77/259 (29%), Positives = 124/259 (47%), Gaps = 14/259 (5%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 +++G LG G FG+VY +A+K + K ++ G + + R +E+ + Sbjct: 10 FEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAG-VEHQLRREVEI----QSH 64 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 ++RL +F LILE P+ ++ + + E+ ++ ++ A+ + Sbjct: 65 LRHPNILRLYGYFHDATRVYLILEYA-PLGTVYRELQKLSKFDEQRTATYITELANALSY 123 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHR 217 CH+ V+HRDIK EN+L+ + GELK+ DFG + T GT Y PPE I R Sbjct: 124 CHSKRVIHRDIKPENLLLG-SAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIE-GR 181 Query: 218 YHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRWCL 271 H +WSLG+L Y+ + G PFE + + I R + F V+ + LI L Sbjct: 182 MHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLL 241 Query: 272 ALRPSDRPTFEEIQNHPWM 290 PS RP E+ HPW+ Sbjct: 242 KHNPSQRPMLREVLEHPWI 260 >5WAX-A nrPDB Length = 310 Score = 110 bits (275), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 80/267 (29%), Positives = 123/267 (46%), Gaps = 24/267 (8%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +Y++ +GSG FG +D VA+K++E+ D ++ ++ Sbjct: 12 RYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKIDEN---------VQREIINHR 62 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156 S +IR + P +++E +LF+ I G E+ AR FF Q++ V Sbjct: 63 SLRHPNIIRFKEVILTPTHLAIVMEYASG-GELFERICNAGRFSEDEARFFFQQLISGVS 121 Query: 157 HCHNCGVLHRDIKDENILIDLNRG-ELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIR 214 +CH+ V HRD+K EN L+D + LK+ DFG S + + + GT Y PE + Sbjct: 122 YCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 181 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ------------RVSSE 262 Y G+ A VWS G+ LY M+ G PFE +E + ++ +S E Sbjct: 182 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISPE 241 Query: 263 CQHLIRWCLALRPSDRPTFEEIQNHPW 289 CQ LI P+ R T EI+NHPW Sbjct: 242 CQDLISRIFVANPATRITIPEIRNHPW 268 >2YCR-A nrPDB Length = 323 Score = 108 bits (270), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 86/279 (30%), Positives = 138/279 (49%), Gaps = 22/279 (7%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDR--ISDWGELPNGTRVPME 89 + L +Y + LGSG G V VAIK + K + I E V E Sbjct: 6 KALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETE 65 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 + +LKK++ +I++ ++F+ D ++ +LE E +LFD + L+E + +F+ Sbjct: 66 IEILKKLNH--PCIIKIKNFFDAEDYYI-VLELMEG-GELFDKVVGNKRLKEATCKLYFY 121 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGE--LKLIDFGSGALLKDT-VYTDFDGTRV 206 Q+L AV++ H G++HRD+K EN+L+ + +K+ DFG +L +T + GT Sbjct: 122 QMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPT 181 Query: 207 YSPPEWIRYHRYHGRSAAV--WSLGILLYDMVCGDIPF-EH------DEEIIRGQVFFR- 256 Y PE + G + AV WSLG++L+ + G PF EH ++I G+ F Sbjct: 182 YLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIP 241 Query: 257 ---QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 VS + L++ L + P R T EE HPW+QD Sbjct: 242 EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 280 >5XZW-A nrPDB Length = 471 Score = 107 bits (267), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 81/282 (28%), Positives = 138/282 (48%), Gaps = 42/282 (14%) Query: 40 VGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 99 + ++G G F +V I + A+K + K ++ + N V E+ +L+K++ Sbjct: 200 IDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKV-----IGNMDGVTRELEVLQKLN-- 252 Query: 100 FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 159 ++RL ++E +S+ +++E DL DF+ GA+ E+ R Q+L A+++ H Sbjct: 253 HPRIVRLKGFYEDTESYYMVMEFVSG-GDLMDFVAAHGAVGEDAGREISRQILTAIKYIH 311 Query: 160 NCGVLHRDIKDENILIDLNRGEL-KLIDF------GSGALLKDTVYTDFDGTRVYSPPEW 212 + G+ HRD+K +NILI+ + L K+ DF G+G+ +K F GT Y PE Sbjct: 312 SMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMK-----TFCGTLAYVAPEV 366 Query: 213 IR----------YHRYHGRSAAV--WSLGILLYDMVCGDIPFEHD------EEIIRGQV- 253 IR Y + S+ V WS+G L+Y ++ G +PF ++I RG Sbjct: 367 IRGKDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYH 426 Query: 254 ---FFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 R+S E + I L + P++R T + NHPW+ D Sbjct: 427 EGPLKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIVD 468 >3HZT-A nrPDB Length = 467 Score = 106 bits (265), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 85/293 (29%), Positives = 143/293 (48%), Gaps = 32/293 (10%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 L +YQ LGSG +G V + D L A + ++ + S N + EV +L Sbjct: 2 LSDRYQRVKKLGSGAYGEV---LLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVAVL 58 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 K++ +++L ++FE ++ L++E +LFD I R E A QVL Sbjct: 59 KQLDH--PNIMKLYEFFEDKRNYYLVMEVYRG-GELFDEIILRQKFSEVDAAVIMKQVLS 115 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRGE--LKLIDFG------SGALLKDTVYTDFDGTR 205 + H ++HRD+K EN+L++ + +K++DFG G +K+ + GT Sbjct: 116 GTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERL-----GTA 170 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHDEEII----RGQVFFR--- 256 Y PE +R + + VWS G++LY ++CG PF + D+EI+ +G+ F Sbjct: 171 YYIAPEVLR--KKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPD 228 Query: 257 -QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLS 308 +VS E + L++ L PS R + EE NHPW+ Q+ ++ H+L+ Sbjct: 229 WTQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWIVK-FCSQKHTDVGKHALT 280 >3DXN-A nrPDB Length = 287 Score = 106 bits (265), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 82/277 (29%), Positives = 136/277 (49%), Gaps = 31/277 (11%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVV 91 + L +YQ LGSG +G V + D L A + ++ + S N + EV Sbjct: 17 QGLSDRYQRVKKLGSGAYGEV---LLCKDKLTGAERAIKIIKKSSVTTTSNSGALLDEVA 73 Query: 92 LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQV 151 +LK++ +++L ++FE ++ L++E +LFD I R E A QV Sbjct: 74 VLKQLDH--PNIMKLYEFFEDKRNYYLVMEVYRG-GELFDEIILRQKFSEVDAAVIMKQV 130 Query: 152 LEAVRHCHNCGVLHRDIKDENILIDLNRGE--LKLIDFG------SGALLKDTVYTDFDG 203 L + H ++HRD+K EN+L++ + +K++DFG G +K+ + G Sbjct: 131 LSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERL-----G 185 Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHDEEII----RGQVFFR- 256 T Y PE +R + + VWS G++LY ++CG PF + D+EI+ +G+ F Sbjct: 186 TAYYIAPEVLR--KKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDP 243 Query: 257 ---QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 +VS E + L++ L PS R + EE NHPW+ Sbjct: 244 PDWTQVSDEAKQLVKLMLTYEPSKRISAEEALNHPWI 280 >3I6U-A nrPDB Length = 419 Score = 105 bits (263), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 85/279 (30%), Positives = 138/279 (49%), Gaps = 22/279 (7%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDR--ISDWGELPNGTRVPME 89 + L +Y + LGSG G V VAI+ + K + I E V E Sbjct: 131 KALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETE 190 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 + +LKK++ +I++ ++F+ D ++ +LE E +LFD + L+E + +F+ Sbjct: 191 IEILKKLNH--PCIIKIKNFFDAEDYYI-VLELMEG-GELFDKVVGNKRLKEATCKLYFY 246 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGE--LKLIDFGSGALLKDT-VYTDFDGTRV 206 Q+L AV++ H G++HRD+K EN+L+ + +K+ DFG +L +T + GT Sbjct: 247 QMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPT 306 Query: 207 YSPPEWIRYHRYHGRSAAV--WSLGILLYDMVCGDIPF-EH------DEEIIRGQVFFR- 256 Y PE + G + AV WSLG++L+ + G PF EH ++I G+ F Sbjct: 307 YLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIP 366 Query: 257 ---QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 VS + L++ L + P R T EE HPW+QD Sbjct: 367 EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQD 405 >2A27-A nrPDB Length = 321 Score = 105 bits (261), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 87/280 (31%), Positives = 134/280 (47%), Gaps = 22/280 (7%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 89 +++ +E Y +G LGSG F V S L A K ++K + + + E Sbjct: 6 KQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIERE 65 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 V +L++V VI L D +E VLILE +LFDF+ ++ +L EE A SF Sbjct: 66 VSILRQVLH--HNVITLHDVYENRTDVVLILELVSG-GELFDFLAQKESLSEEEATSFIK 122 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRG----ELKLIDFGSGALLKDTV-YTDFDGT 204 Q+L+ V + H + H D+K ENI++ L++ +KLIDFG ++D V + + GT Sbjct: 123 QILDGVNYLHTKKIAHFDLKPENIML-LDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGT 181 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD--EEIIRG---------QV 253 + PE + Y G A +WS+G++ Y ++ G PF D +E + + Sbjct: 182 PEFVAPEIVNYEPL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEE 240 Query: 254 FFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 FF Q S + IR L R T +E HPW+ V Sbjct: 241 FFSQ-TSELAKDFIRKLLVKETRKRLTIQEALRHPWITPV 279 >3D2K-A nrPDB Length = 272 Score = 103 bits (258), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 78/270 (28%), Positives = 125/270 (46%), Gaps = 14/270 (5%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 G +++ + +G LG G FG+VY +A+K + K ++ G + + R Sbjct: 4 GSKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAG-VEHQLRRE 62 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSF 147 +E+ + ++RL +F LILE P+ ++ + + E+ ++ Sbjct: 63 VEI----QSHLRHPNILRLYGYFHDATRVYLILEYA-PLGTVYRELQKLSRFDEQRTATY 117 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVY 207 ++ A+ +CH+ V+HRDIK EN+L+ N GELK+ DFG + T GT Y Sbjct: 118 ITELANALSYCHSKRVIHRDIKPENLLLGSN-GELKIADFGWSVHAPSSRRTTLCGTLDY 176 Query: 208 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSS 261 PPE I R H +WSLG+L Y+ + G PFE I R + F V+ Sbjct: 177 LPPEMIE-GRMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFVTE 235 Query: 262 ECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 + LI L S R T E+ HPW++ Sbjct: 236 GARDLISRLLKHNASQRLTLAEVLEHPWIK 265 >3Q5I-A nrPDB Length = 504 Score = 103 bits (258), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 88/285 (30%), Positives = 141/285 (49%), Gaps = 30/285 (10%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTR--- 85 KE + ES ++V L GSG +G V + + AIK ++K + D G + + Sbjct: 30 KEGKIGESYFKVRKL-GSGAYGEVLLCKEKNGHSEKAIKVIKKSQF-DKGRYSDDNKNIE 87 Query: 86 -----VPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQ 140 + E+ LLK + +I+L D FE F L+ E E +LF+ I R Sbjct: 88 KFHEEIYNEISLLKSLDH--PNIIKLFDVFEDKKYFYLVTEFYEG-GELFEQIINRHKFD 144 Query: 141 EELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL---KLIDFG-SGALLKDT 196 E A + Q+L + + H ++HRDIK ENIL++ N+ L K++DFG S KD Sbjct: 145 ECDAANIMKQILSGICYLHKHNIVHRDIKPENILLE-NKNSLLNIKIVDFGLSSFFSKDY 203 Query: 197 VYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHDEEII----R 250 D GT Y PE ++ + + VWS G+++Y ++CG PF ++D++II + Sbjct: 204 KLRDRLGTAYYIAPEVLK--KKYNEKCDVWSCGVIMYILLCGYPPFGGQNDQDIIKKVEK 261 Query: 251 GQVFFR----QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 G+ +F + +S E + LI+ L + R T EE N W++ Sbjct: 262 GKYYFDFNDWKNISDEAKELIKLMLTYDYNKRCTAEEALNSRWIK 306 >3ZUT-A nrPDB Length = 362 Score = 103 bits (257), Expect = 9e-23, Method: Compositional matrix adjust. Identities = 81/267 (30%), Positives = 121/267 (45%), Gaps = 24/267 (8%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +Y++ +GSG FG N VA+K++E+ D V E++ + + Sbjct: 20 RYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID-------ENVKREIINHRSL 72 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156 ++R + P +++E +LF+ I G E+ AR FF Q++ V Sbjct: 73 RH--PNIVRFKEVILTPTHLAIVMEYASG-GELFERICNAGRFSEDEARFFFQQLISGVS 129 Query: 157 HCHNCGVLHRDIKDENILIDLNRG-ELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIR 214 +CH V HRD+K EN L+D + LK+ FG S + + + GT Y PE + Sbjct: 130 YCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEVLL 189 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE----------IIRGQVFFRQRV--SSE 262 Y G+ A VWS G+ LY M+ G PFE EE I+ Q V S E Sbjct: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 Query: 263 CQHLIRWCLALRPSDRPTFEEIQNHPW 289 C+HLI P+ R + EI+NH W Sbjct: 250 CRHLISRIFVADPAKRISIPEIRNHEW 276 >4PDS-A nrPDB Length = 347 Score = 103 bits (256), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 78/278 (28%), Positives = 136/278 (48%), Gaps = 42/278 (15%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 ++G G F +V I + ++K + K ++ + N V E+ +L+K++ Sbjct: 38 VVGQGAFATVKKAIERTTGKTFSVKIISKRKV-----IGNMDGVTRELEVLQKLN--HPR 90 Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCG 162 ++RL ++E +S+ +++E DL DF+ GA+ E+ R Q+L A+++ H+ G Sbjct: 91 IVRLKGFYEDTESYYMVMEFVSG-GDLMDFVAAHGAVGEDAGREISRQILTAIKYIHSMG 149 Query: 163 VLHRDIKDENILIDLNRGEL-KLIDF------GSGALLKDTVYTDFDGTRVYSPPEWIR- 214 + HRD+K +NILI+ + L K+ F G+G+ +K F GT Y PE IR Sbjct: 150 ISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMK-----TFCGTLAYVAPEVIRG 204 Query: 215 ---------YHRYHGRSAAV--WSLGILLYDMVCGDIPFEHD------EEIIRGQV---- 253 Y + S+ V WS+G L+Y ++ G +PF ++I RG Sbjct: 205 KDTSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGP 264 Query: 254 FFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 R+S E + I L + P++R T + NHPW++ Sbjct: 265 LKDFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIK 302 >2YAB-A nrPDB Length = 361 Score = 102 bits (255), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 89/282 (31%), Positives = 135/282 (47%), Gaps = 26/282 (9%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEK--DRISDWGELPNGTRVP 87 +++ +E Y +G LGSG F V S L A K ++K R S G + Sbjct: 6 KQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCRE--EIE 63 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSF 147 EV +L++V +I L D +E VLILE +LFDF+ ++ +L EE A SF Sbjct: 64 REVSILRQVLH--PNIITLHDVYENRTDVVLILELVSG-GELFDFLAQKESLSEEEATSF 120 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG----ELKLIDFGSGALLKDTV-YTDFD 202 Q+L+ V + H + H D+K ENI++ L++ +KLIDFG ++D V + + Sbjct: 121 IKQILDGVNYLHTKKIAHFDLKPENIML-LDKNIPIPHIKLIDFGLAHEIEDGVEFKNIF 179 Query: 203 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD--EEIIRG--------- 251 GT + PE + Y G A +WS+G++ Y ++ G PF D +E + Sbjct: 180 GTPEFVAPEIVNYEPL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFD 238 Query: 252 QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 + FF Q S + IR L R T +E HPW+ V Sbjct: 239 EEFFSQ-TSELAKDFIRKLLVKETRKRLTIQEALRHPWITPV 279 >1ZWS-A nrPDB Length = 288 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 86/280 (30%), Positives = 133/280 (47%), Gaps = 22/280 (7%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 89 +++ +E Y +G LGSG F V S L A K ++K + + + E Sbjct: 6 KQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIERE 65 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 V +L++V VI L D +E VLILE +LFDF+ ++ +L EE A SF Sbjct: 66 VSILRQVLH--HNVITLHDVYENRTDVVLILELVSG-GELFDFLAQKESLSEEEATSFIK 122 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRG----ELKLIDFGSGALLKDTV-YTDFDGT 204 Q+L+ V + H + H D+K ENI++ L++ +KLIDFG ++D V + + GT Sbjct: 123 QILDGVNYLHTKKIAHFDLKPENIML-LDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGT 181 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD--EEIIRG---------QV 253 + PE + Y G A +WS+G++ Y ++ G PF D +E + + Sbjct: 182 PEFVAPEIVNYEPL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEE 240 Query: 254 FFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 FF S + IR L R T +E HPW+ V Sbjct: 241 FFSH-TSELAKDFIRKLLVKETRKRLTIQEALRHPWITPV 279 >3UDB-A nrPDB Length = 317 Score = 102 bits (255), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 81/267 (30%), Positives = 121/267 (45%), Gaps = 24/267 (8%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +Y++ +G+G FG N VA+K++E+ D V E++ + + Sbjct: 20 RYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKID-------ENVKREIINHRSL 72 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156 ++R + P +++E +LF+ I G E+ AR FF Q++ V Sbjct: 73 RH--PNIVRFKEVILTPTHLAIVMEYASG-GELFERICNAGRFSEDEARFFFQQLISGVS 129 Query: 157 HCHNCGVLHRDIKDENILIDLNRG-ELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIR 214 + H V HRD+K EN L+D + LK+ DFG S A + + GT Y PE + Sbjct: 130 YAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEVLL 189 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE----------IIRGQVFFRQRV--SSE 262 Y G+ A VWS G+ LY M+ G PFE EE I+ Q V S E Sbjct: 190 KKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHISPE 249 Query: 263 CQHLIRWCLALRPSDRPTFEEIQNHPW 289 C+HLI P+ R + EI+NH W Sbjct: 250 CRHLISRIFVADPAKRISIPEIRNHEW 276 >4JXF-A nrPDB Length = 266 Score = 102 bits (254), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 78/263 (29%), Positives = 125/263 (47%), Gaps = 19/263 (7%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 ++VG LLG G F VY + L VAIK ++K + G + RV EV + ++ Sbjct: 9 FKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMV---QRVQNEVKIHCQLK 65 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER-GALQEELARSFFWQVLEAVR 156 ++ L ++FE + L+LE ++ ++ R E AR F Q++ + Sbjct: 66 H--PSILELYNYFEDSNYVYLVLEMCHN-GEMNRYLKNRVKPFSENEARHFMHQIITGML 122 Query: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK---DTVYTDFDGTRVYSPPEWI 213 + H+ G+LHRD+ N+L+ N +K+ DFG LK + YT GT Y PE I Sbjct: 123 YLHSHGILHRDLTLSNLLLTRNMN-IKIADFGLATQLKMPHEKHYT-LCGTPNYISPE-I 179 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLI 267 HG + VWSLG + Y ++ G PF+ D +++ +S E + LI Sbjct: 180 ATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLI 239 Query: 268 RWCLALRPSDRPTFEEIQNHPWM 290 L P+DR + + +HP+M Sbjct: 240 HQLLRRNPADRLSLSSVLDHPFM 262 >3LIJ-A nrPDB Length = 494 Score = 102 bits (253), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 89/307 (28%), Positives = 152/307 (49%), Gaps = 30/307 (9%) Query: 19 DLHATKLAPG----KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRI 74 DL AT PG +K L YQ LGSG +G V ++ AIK + K + Sbjct: 19 DLQAT---PGMFITSKKGHLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSV 75 Query: 75 SDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT 134 S + +++ EV +LK + +++L D+FE ++ L++E + +LFD I Sbjct: 76 S----TSSNSKLLEEVAVLKLLDH--PNIMKLYDFFEDKRNYYLVMECYKG-GELFDEII 128 Query: 135 ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE--LKLIDFGSGAL 192 R E A QVL V + H ++HRD+K EN+L++ + +K++DFG A+ Sbjct: 129 HRMKFNEVDAAVIIKQVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAV 188 Query: 193 LKD-TVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHDEEII 249 ++ + GT Y PE +R + + VWS+G++L+ ++ G PF + D+EI+ Sbjct: 189 FENQKKMKERLGTAYYIAPEVLR--KKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEIL 246 Query: 250 R----GQVFFR----QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAE 301 R G+ F + VS + LI+ L R + ++ HPW++++ +E+ Sbjct: 247 RKVEKGKYTFDSPEWKNVSEGAKDLIKQMLQFDSQRRISAQQALEHPWIKEMCSKKESG- 305 Query: 302 IHLHSLS 308 I L SL+ Sbjct: 306 IELPSLA 312 >3UC3-A nrPDB Length = 361 Score = 101 bits (252), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 80/263 (30%), Positives = 121/263 (46%), Gaps = 30/263 (11%) Query: 44 LGSGGFGSVYSGIRVSDNLP---VAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGF 100 +GSG FG V +R D L VA+K++E+ D ++ ++ S Sbjct: 28 IGSGNFG-VARLMR--DKLTKELVAVKYIERGAAIDEN---------VQREIINHRSLRH 75 Query: 101 SGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHN 160 ++R + P +I+E +L++ I G E+ AR FF Q+L V +CH+ Sbjct: 76 PNIVRFKEVILTPTHLAIIMEYASG-GELYERICNAGRFSEDEARFFFQQLLSGVSYCHS 134 Query: 161 CGVLHRDIKDENILIDLNRG-ELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIRYHRY 218 + HRD+K EN L+D + LK+ DFG S + + + GT Y PE + Y Sbjct: 135 MQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVLLRQEY 194 Query: 219 HGRSAAVWSLGILLYDMVCGDIPFEHDEE------------IIRGQVFFRQRVSSECQHL 266 G+ A VWS G+ LY M+ G PFE EE ++ + R+S EC HL Sbjct: 195 DGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRISPECCHL 254 Query: 267 IRWCLALRPSDRPTFEEIQNHPW 289 I P+ R + EI+ H W Sbjct: 255 ISRIFVADPATRISIPEIKTHSW 277 >2JC6-A nrPDB Length = 334 Score = 100 bits (250), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 75/275 (27%), Positives = 133/275 (48%), Gaps = 22/275 (8%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 K+ E ++ ++ LG+G F V + A+K + K + + + Sbjct: 15 KQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKG-----KESSIEN 69 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 148 E+ +L+K+ ++ L D +E P+ L+++ +LFD I E+G E+ A + Sbjct: 70 EIAVLRKIK--HENIVALEDIYESPNHLYLVMQLVSG-GELFDRIVEKGFYTEKDASTLI 126 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLI--DFGSGALL-KDTVYTDFDGTR 205 QVL+AV + H G++HRD+K EN+L E K++ DFG + K V + GT Sbjct: 127 RQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTP 186 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHD----EEIIRGQVFFRQ-- 257 Y PE + + + ++ WS+G++ Y ++CG PF E+D E+I++ + F Sbjct: 187 GYVAPE-VLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPY 245 Query: 258 --RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 +S + IR + P+ R T E+ HPW+ Sbjct: 246 WDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI 280 >5JZN-A nrPDB Length = 280 Score = 100 bits (249), Expect = 9e-22, Method: Compositional matrix adjust. Identities = 74/274 (27%), Positives = 127/274 (46%), Gaps = 25/274 (9%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 + +Y+VG +G G F V + S A+K ++K + + + EV +L Sbjct: 17 ITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHM-----IQNEVSIL 71 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 ++V ++ L++ + P L++E + DLFD IT E A + + Sbjct: 72 RRVKH--PNIVLLIEEMDVPTELYLVMELVKG-GDLFDAITSTNKYTERDASGMLYNLAS 128 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRG---ELKLIDFGSGALLKDTVYTDFDGTRVYSPP 210 A+++ H+ ++HRDIK EN+L+ ++ LKL DFG ++ +YT GT Y P Sbjct: 129 AIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYT-VCGTPTYVAP 187 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE---HDEEIIRGQVFFRQ---------R 258 E I Y G +W+ G++ Y ++CG PF D+E++ Q+ Q Sbjct: 188 EIIAETGY-GLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDN 246 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 VS + LI L + R + ++ HPW+ D Sbjct: 247 VSDSAKELITMMLLVDVDQRFSAVQVLEHPWVND 280 >5D9K-A nrPDB Length = 330 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 79/277 (28%), Positives = 141/277 (50%), Gaps = 31/277 (11%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLP---VAIKHVEKDRISDWGELPNGTRVPMEVVL 92 SQ+++ +LG G FG V+ ++S + A+K ++K + ++ + R ME + Sbjct: 30 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATL----KVRDRVRTKMERDI 85 Query: 93 LKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 L +V+ F +++L F+ LIL+ DLF +++ EE + + ++ Sbjct: 86 LVEVNHPF--IVKLHYAFQTEGKLYLILDFLRG-GDLFTRLSKEVMFTEEDVKFYLAELA 142 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV-----YTDFDGTRVY 207 A+ H H+ G+++RD+K ENIL+D G +KL DFG L K+++ F GT Y Sbjct: 143 LALDHLHSLGIIYRDLKPENILLD-EEGHIKLTDFG---LSKESIDHEKKAYSFCGTVEY 198 Query: 208 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRVSS 261 PE + R H +SA WS G+L+++M+ G +PF+ + I++ ++ Q +S Sbjct: 199 MAPEVVN-RRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSP 257 Query: 262 ECQHLIRWCLALRPSDR-----PTFEEIQNHPWMQDV 293 E Q L+R P++R EEI+ H + + Sbjct: 258 EAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTI 294 >5DYK-A nrPDB Length = 853 Score = 99.4 bits (246), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 77/264 (29%), Positives = 132/264 (50%), Gaps = 23/264 (8%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 ++G G FG+V + A+K V K I + + N ++ E+ + Sbjct: 546 IIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQ-QNNIKLEREIT----AENDHPF 600 Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCG 162 +IRL+ F+ F + E +L+D I + G L + A+ + ++ A+ + H Sbjct: 601 IIRLVRTFKDSKYFYFLTELVTG-GELYDAIRKLGLLSKSQAQFYLGSIILAIEYLHERN 659 Query: 163 VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRS 222 +++RD+K ENIL+D +G +KLIDFG ++ YT GT Y PE I Y G + Sbjct: 660 IVYRDLKPENILLD-KQGYVKLIDFGCAKKVQGRAYT-LVGTPHYMAPEVILGKGY-GCT 716 Query: 223 AAVWSLGILLYDMVCGDIPFEHDEE--------IIRGQVFFRQRVS-SECQHLIRWCLAL 273 +W+LGI LY+ +CG +PF +DEE I+ GQ+ F V+ ++ +L++ L Sbjct: 717 VDIWALGICLYEFICGPLPFGNDEEDQLEIFRDILTGQLTFPDYVTDTDSINLMKRLLCR 776 Query: 274 RPSDR-----PTFEEIQNHPWMQD 292 P R F++I++HP+ + Sbjct: 777 LPQGRIGCSINGFKDIKDHPFFSN 800 >2W4O-A nrPDB Length = 349 Score = 98.2 bits (243), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 86/281 (30%), Positives = 128/281 (45%), Gaps = 34/281 (12%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 G ++ L ++V LG G VY + P A+K ++K + V Sbjct: 45 GSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKT--------VDKKIVR 96 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSF 147 E+ +L ++S +I+L + FE P L+LE +LFD I E+G E A Sbjct: 97 TEIGVLLRLSH--PNIIKLKEIFETPTEISLVLELVTG-GELFDRIVEKGYYSERDAADA 153 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNR--GELKLIDFGSGALLKDTV-YTDFDGT 204 Q+LEAV + H G++HRD+K EN+L LK+ DFG +++ V GT Sbjct: 154 VKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGT 213 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR------ 258 Y PE +R Y G +WS+GI+ Y ++CG PF +DE RG F +R Sbjct: 214 PGYCAPEILRGCAY-GPEVDMWSVGIITYILLCGFEPF-YDE---RGDQFMFRRILNCEY 268 Query: 259 ---------VSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 VS + L+R + L P R T + HPW+ Sbjct: 269 YFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWV 309 >4B8L-A nrPDB Length = 286 Score = 98.2 bits (243), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 74/276 (26%), Positives = 127/276 (46%), Gaps = 14/276 (5%) Query: 22 ATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELP 81 AT LA +++ + +G LG G FG+VY + +A+K + K ++ G + Sbjct: 1 ATALAEMPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEG-VE 59 Query: 82 NGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQE 141 + R +E+ + ++R+ ++F L+LE P +L+ + + G E Sbjct: 60 HQLRREIEI----QSHLRHPNILRMYNYFHDRKRIYLMLEF-APRGELYKELQKHGRFDE 114 Query: 142 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDF 201 + + +F ++ +A+ +CH V+HRDIK EN+L+ +GELK+ DFG Sbjct: 115 QRSATFMEELADALHYCHERKVIHRDIKPENLLMGY-KGELKIADFGWSVHAPSLRRRTM 173 Query: 202 DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF------EHDEEIIRGQVFF 255 GT Y PPE I + H +W G+L Y+ + G PF E I+ + F Sbjct: 174 CGTLDYLPPEMIE-GKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKF 232 Query: 256 RQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 +S + LI L P R + + HPW++ Sbjct: 233 PPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVK 268 >2J90-A nrPDB Length = 304 Score = 98.2 bits (243), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 81/275 (29%), Positives = 129/275 (46%), Gaps = 20/275 (7%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 +E Y++G LGSG F V + A K ++K R+S + + EV +L Sbjct: 24 VEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNIL 83 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 +++ +I L D FE VLILE +LFDF+ E+ +L E+ A F Q+L+ Sbjct: 84 REIRH--PNIITLHDIFENKTDVVLILELVSG-GELFDFLAEKESLTEDEATQFLKQILD 140 Query: 154 AVRHCHNCGVLHRDIKDENI-LIDLN--RGELKLIDFG-SGALLKDTVYTDFDGTRVYSP 209 V + H+ + H D+K ENI L+D N +KLIDFG + + + + GT + Sbjct: 141 GVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVA 200 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHDEEIIRG---------QVFFRQR 258 PE + Y G A +WS+G++ Y ++ G PF E +E + + +F Sbjct: 201 PEIVNYEPL-GLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYF-SN 258 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 S + IR L P R T + H W++ + Sbjct: 259 TSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAI 293 >3DFA-A nrPDB Length = 286 Score = 98.2 bits (243), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 79/268 (29%), Positives = 125/268 (46%), Gaps = 22/268 (8%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +Y + +LG G FG V A+K + K + + + + EV LLKK+ Sbjct: 23 RYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKN----KDTSTILREVELLKKL 78 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156 +++L + E SF ++ E +LFD I +R E A QV + Sbjct: 79 DH--PNIMKLFEILEDSSSFYIVGELYTG-GELFDEIIKRKRFSEHDAARIIKQVFSGIT 135 Query: 157 HCHNCGVLHRDIKDENILIDLNRG--ELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWI 213 + H ++HRD+K ENIL++ ++K+IDFG S ++T D GT Y PE + Sbjct: 136 YMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL 195 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPF----EHD--EEIIRGQVFFR----QRVSSEC 263 R + VWS G++LY ++ G PF E+D + + G+ F + +S + Sbjct: 196 R--GTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDA 253 Query: 264 QHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 + LIR L PS R T + HPW+Q Sbjct: 254 KDLIRKMLTFHPSLRITATQCLEHPWIQ 281 >3NCG-A nrPDB Length = 486 Score = 97.8 bits (242), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 79/268 (29%), Positives = 125/268 (46%), Gaps = 22/268 (8%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +Y + +LG G FG V A+K + K + + + + EV LLKK+ Sbjct: 23 RYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKN----KDTSTILREVELLKKL 78 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156 +++L + E SF ++ E +LFD I +R E A QV + Sbjct: 79 DH--PNIMKLFEILEDSSSFYIVGELYTG-GELFDEIIKRKRFSEHDAARIIKQVFSGIT 135 Query: 157 HCHNCGVLHRDIKDENILIDLNRG--ELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWI 213 + H ++HRD+K ENIL++ ++K+IDFG S ++T D GT Y PE + Sbjct: 136 YMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAPEVL 195 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPF----EHD--EEIIRGQVFFR----QRVSSEC 263 R + VWS G++LY ++ G PF E+D + + G+ F + +S + Sbjct: 196 R--GTYDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTISDDA 253 Query: 264 QHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 + LIR L PS R T + HPW+Q Sbjct: 254 KDLIRKMLTFHPSLRITATQCLEHPWIQ 281 >3GUB-A nrPDB Length = 295 Score = 97.4 bits (241), Expect = 7e-21, Method: Compositional matrix adjust. Identities = 82/285 (28%), Positives = 132/285 (46%), Gaps = 22/285 (7%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 +E ++ Y G LGSG F V S L A K ++K R + + EV Sbjct: 6 QENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREV 65 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQ 150 +LK++ VI L + +E +LI E +LFDF+ E+ +L EE A F Q Sbjct: 66 SILKEIQH--PNVITLHEVYENKTDVILIGELVAG-GELFDFLAEKESLTEEEATEFLKQ 122 Query: 151 VLEAVRHCHNCGVLHRDIKDENI-LIDLN--RGELKLIDFGSGALLK-DTVYTDFDGTRV 206 +L V + H+ + H D+K ENI L+D N + +K+IDFG + + + GT Sbjct: 123 ILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPE 182 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD--EEIIRG--------QVFFR 256 + PE + Y G A +WS+G++ Y ++ G PF D +E + + + Sbjct: 183 FVAPEIVNYEPL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYF 241 Query: 257 QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAE 301 S+ + IR L P R T ++ HPW++ P++T + Sbjct: 242 SNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIK----PKDTQQ 282 >2VZ6-A nrPDB Length = 313 Score = 97.4 bits (241), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 87/279 (31%), Positives = 125/279 (44%), Gaps = 26/279 (9%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRIS--DWGELPNGTR 85 G E +S YQ+ LG G F V ++V A K + ++S D +L R Sbjct: 14 GTENLYFQSMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREAR 73 Query: 86 VPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELAR 145 + LLK ++RL D LI + +LF+ I R E A Sbjct: 74 I---CRLLKH-----PNIVRLHDSISEEGHHYLIFDLVTG-GELFEDIVAREYYSEADAS 124 Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILI--DLNRGELKLIDFGSGALL--KDTVYTDF 201 Q+LEAV HCH GV+HRD+K EN+L+ L +KL DFG + + + F Sbjct: 125 HCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGF 184 Query: 202 DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF----EHD--EEIIRGQVFF 255 GT Y PE +R Y G+ +W+ G++LY ++ G PF +H ++I G F Sbjct: 185 AGTPGYLSPEVLRKDPY-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDF 243 Query: 256 RQ----RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 V+ E + LI L + PS R T E HPW+ Sbjct: 244 PSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI 282 >4AF3-A nrPDB Length = 292 Score = 95.1 bits (235), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 78/260 (30%), Positives = 127/260 (48%), Gaps = 14/260 (5%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 +++G LG G FG+VY + VA+K + K +I G + + R +E+ + Sbjct: 25 FEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEG-VEHQLRREIEI----QAH 79 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 ++RL ++F LILE P +L+ + + E+ + ++ +A+ + Sbjct: 80 LHHPNILRLYNYFYDRRRIYLILEY-APRGELYKELQKSCTFDEQRTATIMEELADALMY 138 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHR 217 CH V+HRDIK EN+L+ L GELK+ DFG GT Y PPE I R Sbjct: 139 CHGKKVIHRDIKPENLLLGLK-GELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIE-GR 196 Query: 218 YHGRSAAVWSLGILLYDMVCGDIPFE---HDE---EIIRGQVFFRQRVSSECQHLIRWCL 271 H +W +G+L Y+++ G+ PFE H+E I++ + F V + Q LI L Sbjct: 197 MHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGAQDLISKLL 256 Query: 272 ALRPSDRPTFEEIQNHPWMQ 291 PS+R ++ HPW++ Sbjct: 257 RHNPSERLPLAQVSAHPWVR 276 >2JAM-A nrPDB Length = 304 Score = 95.1 bits (235), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 73/260 (28%), Positives = 122/260 (46%), Gaps = 22/260 (8%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 +LGSG F V+ + A+K ++K L N E+ +LKK+ Sbjct: 16 VLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLEN------EIAVLKKIKH--EN 67 Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCG 162 ++ L D +E + L+++ +LFD I ERG E+ A QVL AV++ H G Sbjct: 68 IVTLEDIYESTTHYYLVMQLVSG-GELFDRILERGVYTEKDASLVIQQVLSAVKYLHENG 126 Query: 163 VLHRDIKDENILIDL--NRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHG 220 ++HRD+K EN+L ++ + DFG + ++ + + GT Y PE + Y Sbjct: 127 IVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQKPY-S 185 Query: 221 RSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQ----RVSSECQHLIRWC 270 ++ WS+G++ Y ++CG PF + E+I G F +S + I Sbjct: 186 KAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHL 245 Query: 271 LALRPSDRPTFEEIQNHPWM 290 L P++R T E+ +HPW+ Sbjct: 246 LEKDPNERYTCEKALSHPWI 265 >3BHH-A nrPDB Length = 295 Score = 94.7 bits (234), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 80/273 (29%), Positives = 124/273 (45%), Gaps = 26/273 (9%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRIS--DWGELPNGTRVPMEVV 91 + +YQ+ +G G F V +++ A K + ++S D +L R+ Sbjct: 2 MTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARI---CR 58 Query: 92 LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQV 151 LLK S ++RL D L+ + +LF+ I R E A Q+ Sbjct: 59 LLK-----HSNIVRLHDSISEEGFHYLVFDLVTG-GELFEDIVAREYYSEADASHCIQQI 112 Query: 152 LEAVRHCHNCGVLHRDIKDENILI--DLNRGELKLIDFGSGALLK--DTVYTDFDGTRVY 207 LEAV HCH GV+HRD+K EN+L+ +KL DFG ++ + F GT Y Sbjct: 113 LEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY 172 Query: 208 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF----EHD--EEIIRGQVFFRQ---- 257 PE +R Y G+ +W+ G++LY ++ G PF +H ++I G F Sbjct: 173 LSPEVLRKEAY-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWD 231 Query: 258 RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 V+ E ++LI L + P+ R T E HPW+ Sbjct: 232 TVTPEAKNLINQMLTINPAKRITAHEALKHPWV 264 >5CEK-A nrPDB Length = 263 Score = 94.4 bits (233), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 73/242 (30%), Positives = 114/242 (47%), Gaps = 36/242 (14%) Query: 66 IKHVEKDRISDWGELPNGTRVP--MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERP 123 IKH + D+I + +LP+ + + +EV+L G + +FE+ Sbjct: 44 IKHYQ-DKIRPYIQLPSHSNITGIVEVIL---------GETKAYVFFEKD---------- 83 Query: 124 EPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLN-RGEL 182 D+ ++ R L+EE A F Q++ AV HCH ++ D+K + R +L Sbjct: 84 --FGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQL 141 Query: 183 KLIDFGSGALLK--DTVYTDFDGTRVYSPPEWIRYH-RYHGRSAAVWSLGILLYDMVCGD 239 +L ++K D +D G Y PE + Y G++A VWSLG++LY ++ G Sbjct: 142 RLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGR 201 Query: 240 IPFEHDEE-------IIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 PF HD + I RGQ + +S + + LIR L PS+R T EI HPW + Sbjct: 202 YPF-HDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFES 260 Query: 293 VL 294 VL Sbjct: 261 VL 262 >6DC0-A nrPDB Length = 292 Score = 94.0 bits (232), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 73/242 (30%), Positives = 114/242 (47%), Gaps = 36/242 (14%) Query: 66 IKHVEKDRISDWGELPNGTRVP--MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERP 123 IKH + D+I + +LP+ + + +EV+L G + +FE+ Sbjct: 41 IKHYQ-DKIRPYIQLPSHSNITGIVEVIL---------GETKAYVFFEKD---------- 80 Query: 124 EPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLN-RGEL 182 D+ ++ R L+EE A F Q++ AV HCH ++ D+K + R +L Sbjct: 81 --FGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQL 138 Query: 183 KLIDFGSGALLK--DTVYTDFDGTRVYSPPEWIRYH-RYHGRSAAVWSLGILLYDMVCGD 239 +L ++K D +D G Y PE + Y G++A VWSLG++LY ++ G Sbjct: 139 RLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGR 198 Query: 240 IPFEHDEE-------IIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 PF HD + I RGQ + +S + + LIR L PS+R T EI HPW + Sbjct: 199 YPF-HDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFES 257 Query: 293 VL 294 VL Sbjct: 258 VL 259 >5FET-A nrPDB Length = 847 Score = 94.0 bits (232), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 75/262 (28%), Positives = 128/262 (48%), Gaps = 23/262 (8%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 ++G G FG+V + A+K V K I + N ++ E+ + Sbjct: 540 IIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQ-QNNIKLEREIT----AENDHPF 594 Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCG 162 +IRL+ F+ + F + E +L+D I + G L + A+ + ++ A+ + H Sbjct: 595 IIRLVRTFKDSNCFYFLTELVTG-GELYDAIRKLGLLSKPQAQFYLGSIILAIEYLHERN 653 Query: 163 VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRS 222 +++RD+K ENIL+D +G +KLIDFG ++ YT GT Y PE I Y G + Sbjct: 654 IVYRDLKPENILLD-KQGYVKLIDFGCAKKIQGRAYT-LVGTPHYMAPEVILGKGY-GCT 710 Query: 223 AAVWSLGILLYDMVCGDIPFEHDEE--------IIRGQVFFRQRVSSE-CQHLIRWCLAL 273 +W+LG+ LY+ +CG +PF +D+E I+ GQ+ F VS + +L++ L Sbjct: 711 VDIWALGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVSDQDSINLMKRLLCR 770 Query: 274 RPSDR-----PTFEEIQNHPWM 290 P R F++I+ H + Sbjct: 771 LPQGRIGCSINGFKDIKEHAFF 792 >2Z7Q-A nrPDB Length = 321 Score = 94.0 bits (232), Expect = 8e-20, Method: Compositional matrix adjust. Identities = 76/274 (27%), Positives = 135/274 (49%), Gaps = 25/274 (9%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVS---DNLPVAIKHVEKDRISDWGELPNGTRVPMEVVL 92 S +++ +LG G FG V+ +V+ A+K ++K + ++ + R ME + Sbjct: 28 SHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATL----KVRDRVRTKMERDI 83 Query: 93 LKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 L V+ F V++L F+ LIL+ DLF +++ EE + + ++ Sbjct: 84 LADVNHPF--VVKLHYAFQTEGKLYLILDFLRG-GDLFTRLSKEVMFTEEDVKFYLAELA 140 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG--SGALLKDTVYTDFDGTRVYSPP 210 + H H+ G+++RD+K ENIL+D G +KL DFG A+ + F GT Y P Sbjct: 141 LGLDHLHSLGIIYRDLKPENILLD-EEGHIKLTDFGLSKEAIDHEKKAYSFCGTVEYMAP 199 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRVSSECQ 264 E + + H SA WS G+L+++M+ G +PF+ + I++ ++ Q +S+E Q Sbjct: 200 EVVN-RQGHSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMPQFLSTEAQ 258 Query: 265 HLIRWCLALRPSDR-----PTFEEIQNHPWMQDV 293 L+R P++R EEI+ H + + Sbjct: 259 SLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTI 292 >4FG9-A nrPDB Length = 320 Score = 93.6 bits (231), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 78/277 (28%), Positives = 133/277 (48%), Gaps = 26/277 (9%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRI-SDWGELPNGTRVP 87 K+ E + Y +LG+G F V VAIK + K+ + G + N Sbjct: 11 KQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMEN----- 65 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSF 147 E+ +L K+ ++ L D +E LI++ +LFD I E+G E A Sbjct: 66 -EIAVLHKIKH--PNIVALDDIYESGGHLYLIMQLVSG-GELFDRIVEKGFYTERDASRL 121 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENIL---IDLNRGELKLIDFGSGALLK-DTVYTDFDG 203 +QVL+AV++ H+ G++HRD+K EN+L +D + ++ + DFG + +V + G Sbjct: 122 IFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDED-SKIMISDFGLSKMEDPGSVLSTACG 180 Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHD----EEIIRGQVFFRQ 257 T Y PE + + + ++ WS+G++ Y ++CG PF E+D E+I++ + F Sbjct: 181 TPGYVAPE-VLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDS 239 Query: 258 ----RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 +S + IR + P R T E+ HPW+ Sbjct: 240 PYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276 >5IG1-A nrPDB Length = 344 Score = 93.6 bits (231), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 71/263 (26%), Positives = 123/263 (46%), Gaps = 25/263 (9%) Query: 43 LLGSGGFGSVYSGI--RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGF 100 ++G G F +V+ + R + V + ++ R S+ ++ E+ + + Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRSSEIN------KIKREIGICSSLQH-- 75 Query: 101 SGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHN 160 ++ + F F L+ E +LFD I R E+ A + Q+L A++HCH+ Sbjct: 76 EHIVSMRRAFRDESHFYLVFEYVSG-GELFDEIVTRKFYNEKDASACMHQILSALQHCHS 134 Query: 161 CGVLHRDIKDENILIDLN--RGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPEWIRYHR 217 ++HRD+K EN+L+ +K+ DFG +++ Y F GT Y PE IR Sbjct: 135 KNIIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRVP 194 Query: 218 YHGRSAAVWSLGILLYDMVCGDIPF-EHDEEIIRGQVFFRQ---------RVSSECQHLI 267 Y + VW+ G++LY ++ G PF E D + + Q+ Q V++ + LI Sbjct: 195 Y-DTAVDVWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTAAKELI 253 Query: 268 RWCLALRPSDRPTFEEIQNHPWM 290 + L P RPT +E+ HPW+ Sbjct: 254 KAMLEPNPKRRPTVQELLQHPWI 276 >1PHK-A nrPDB Length = 298 Score = 93.2 bits (230), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 70/225 (31%), Positives = 111/225 (49%), Gaps = 19/225 (8%) Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 148 EV +L+KVS G +I+L D +E F L+ + + +LFD++TE+ L E+ R Sbjct: 73 EVDILRKVS-GHPNIIQLKDTYETNTFFFLVFDLMKK-GELFDYLTEKVTLSEKETRKIM 130 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDGTRVY 207 +LE + H ++HRD+K ENIL+D + +KL DFG S L + GT Y Sbjct: 131 RALLEVICALHKLNIVHRDLKPENILLD-DDMNIKLTDFGFSCQLDPGEKLREVCGTPSY 189 Query: 208 SPPEWIR-----YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFR 256 PE I H +G+ +WS G+++Y ++ G PF H ++ I+ G F Sbjct: 190 LAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFG 249 Query: 257 Q----RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQ 297 S + L+ L ++P R T EE HP+ Q ++ + Sbjct: 250 SPEWDDYSDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQQYVVEE 294 >5U6Y-A nrPDB Length = 461 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 84/269 (31%), Positives = 121/269 (44%), Gaps = 26/269 (9%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRIS--DWGELPNGTRVPMEVVLLKK 95 YQ+ LG G F V ++V A K + ++S D +L R+ LLK Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARI---CRLLK- 57 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 ++RL D LI + +LF+ I R E A Q+LEAV Sbjct: 58 ----HPNIVRLHDSISEEGHHYLIFDLVTG-GELFEDIVAREYYSEADASHCIQQILEAV 112 Query: 156 RHCHNCGVLHRDIKDENILI--DLNRGELKLIDFGSGALL--KDTVYTDFDGTRVYSPPE 211 HCH GV+HRD+K EN+L+ L +KL DFG + + + F GT Y PE Sbjct: 113 LHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPE 172 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPF----EHD--EEIIRGQVFFRQ----RVSS 261 +R Y G+ +W+ G++LY ++ G PF +H ++I G F V+ Sbjct: 173 VLRKDPY-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTP 231 Query: 262 ECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 E + LI L + PS R T E HPW+ Sbjct: 232 EAKDLINKMLTINPSKRITAAEALKHPWI 260 >2Y7J-A nrPDB Length = 365 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 78/246 (31%), Positives = 123/246 (50%), Gaps = 23/246 (9%) Query: 64 VAIKHVEKDRIS--DWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILE 121 V I V +R+S E+ TR E +L++V+ G +I L+D +E SF+ ++ Sbjct: 124 VKIMEVTAERLSPEQLEEVREATR--RETHILRQVA-GHPHIITLIDSYE-SSSFMFLVF 179 Query: 122 RPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE 181 +LFD++TE+ AL E+ RS +LEAV H ++HRD+K ENIL+D N + Sbjct: 180 DLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENILLDDNM-Q 238 Query: 182 LKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIR-----YHRYHGRSAAVWSLGILLYDM 235 ++L DFG S L + GT Y PE ++ H +G+ +W+ G++L+ + Sbjct: 239 IRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWACGVILFTL 298 Query: 236 VCGDIPFEHDEEII------RGQVFFRQ----RVSSECQHLIRWCLALRPSDRPTFEEIQ 285 + G PF H +I+ GQ F SS + LI L + P R T E+ Sbjct: 299 LAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEARLTAEQAL 358 Query: 286 NHPWMQ 291 HP+ + Sbjct: 359 QHPFFE 364 >5FG8-A nrPDB Length = 285 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 73/273 (26%), Positives = 122/273 (44%), Gaps = 26/273 (9%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRIS--DWGELPNGTRVPMEVV 91 Y + LG G F V ++ S A K + +++ D+ +L R+ ++ Sbjct: 12 FSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKL- 70 Query: 92 LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQV 151 ++RL D + + L+ + +LF+ I R E A Q+ Sbjct: 71 -------HHPNIVRLHDSIQEENYHYLVFDLVTG-GELFEDIVAREFYSEADASHCIQQI 122 Query: 152 LEAVRHCHNCGVLHRDIKDENILI--DLNRGELKLIDFGSGALLKD--TVYTDFDGTRVY 207 LE+V HCH GV+HRD+K EN+L+ +KL DFG ++ + F GT Y Sbjct: 123 LESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGY 182 Query: 208 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF-EHDEEIIRGQVFFR---------Q 257 PE ++ Y G+S +W+ G++LY ++ G PF + D+ + Q+ Sbjct: 183 LSPEVLKKEPY-GKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWD 241 Query: 258 RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 V+ E ++LI L + P+ R T E HPW+ Sbjct: 242 TVTPEAKNLINQMLTVNPNKRITAAEALKHPWI 274 >6BDL-A nrPDB Length = 347 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 76/271 (28%), Positives = 137/271 (50%), Gaps = 23/271 (8%) Query: 36 SQYQVGPLLGSGGFGSV-YSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 S + + LG GGFG V ++ ++ A+K ++K I D + + + E +++ Sbjct: 34 SDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEH---IRSEKQIMQ 90 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 S F ++RL F+ +++E +L+ + +RG+ ++ R + V+EA Sbjct: 91 GAHSDF--IVRLYRTFKDSKYLYMLMEACLG-GELWTILRDRGSFEDSTTRFYTACVVEA 147 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT-DFDGTRVYSPPEWI 213 + H+ G+++RD+K EN+++D +RG KL+DFG + T F GT Y PE I Sbjct: 148 FAYLHSKGIIYRDLKPENLILD-HRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEII 206 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRG--QVFFRQRVSSECQH 265 ++ H SA WSLGIL+Y+++ G PF + I+RG + F ++++ + Sbjct: 207 -LNKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAAN 265 Query: 266 LIRWCLALRPSDR-----PTFEEIQNHPWMQ 291 LI+ PS+R ++IQ H W + Sbjct: 266 LIKKLCRDNPSERLGNLKNGVKDIQKHKWFE 296 >4EQM-A nrPDB Length = 294 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 68/218 (31%), Positives = 109/218 (50%), Gaps = 23/218 (10%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHV-----EKDRISDWGELPNGTRVPM 88 + +Y++ LG GG +VY N+ VAIK + EK+ R Sbjct: 9 INERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEE--------TLKRFER 60 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPE-PVQDLFDFITERGALQEELARSF 147 EV ++S ++ ++D E D + L++E E P L ++I G L + A +F Sbjct: 61 EVHNSSQLS--HQNIVSMIDVDEEDDCYYLVMEYIEGPT--LSEYIESHGPLSVDTAINF 116 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD---GT 204 Q+L+ ++H H+ ++HRDIK +NILID N+ LK+ DFG L +T T + GT Sbjct: 117 TNQILDGIKHAHDMRIVHRDIKPQNILIDSNKT-LKIFDFGIAKALSETSLTQTNHVLGT 175 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF 242 Y PE + ++S+GI+LY+M+ G+ PF Sbjct: 176 VQYFSPEQAK-GEATDECTDIYSIGIVLYEMLVGEPPF 212 >4KRC-A nrPDB Length = 317 Score = 92.4 bits (228), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 69/226 (30%), Positives = 112/226 (49%), Gaps = 22/226 (9%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 SQ++ LG+G + +VY G+ + + VA+K V+ D S+ G R E+ L+K+ Sbjct: 5 SQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD--SEEGTPSTAIR---EISLMKE 59 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG------ALQEELARSFFW 149 + ++RL D + L+ E + DL ++ R L+ L + F W Sbjct: 60 LKH--ENIVRLYDVIHTENKLTLVFEFMD--NDLKKYMDSRTVGNTPRGLELNLVKYFQW 115 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV--- 206 Q+L+ + CH +LHRD+K +N+LI+ RG+LKL DFG V T F V Sbjct: 116 QLLQGLAFCHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNT-FSSEVVTLW 173 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGD--IPFEHDEEIIR 250 Y P+ + R + S +WS G +L +M+ G P +DEE ++ Sbjct: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLK 219 >6FDY-U nrPDB Length = 276 Score = 92.0 bits (227), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 79/260 (30%), Positives = 128/260 (49%), Gaps = 22/260 (8%) Query: 44 LGSGGFGSVYSGIRVSDNLPV-AIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 LGSG + +VY D V AIK V K ++ + + E+ +LK + Sbjct: 19 LGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNK----ASVENLLTEIEILKGIRH--PH 72 Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCG 162 +++L D+ D+ LI+E DL FI R L E++AR F Q+ A++ H Sbjct: 73 IVQLKDFQWDSDNIYLIMEFCAG-GDLSRFIHTRRILPEKVARVFMQQLASALQFLHERN 131 Query: 163 VLHRDIKDENILI-DLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPEWIRYHRYH 219 + H D+K +NIL+ L + LKL DFG + D + G+ +Y PE + +Y Sbjct: 132 ISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHV-LRGSPLYMAPEMVCQRQYD 190 Query: 220 GRSAAVWSLGILLYDMVCGDIPF------EHDEEIIRGQVF---FRQRVSSECQHLIRWC 270 R +WS+G++LY+ + G PF E +E+I +V R +S +C+ L++ Sbjct: 191 AR-VDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQRL 249 Query: 271 LALRPSDRPTFEEIQNHPWM 290 L PS R +F++ HPW+ Sbjct: 250 LERDPSRRISFQDFFAHPWV 269 >6QAU-A nrPDB Length = 280 Score = 92.0 bits (227), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 67/219 (30%), Positives = 110/219 (50%), Gaps = 19/219 (8%) Query: 37 QYQVGPLLGSGGFGSVYSGI-RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +Y L+G G F V+ G R + VAIK + K +S L + E+ +LK+ Sbjct: 12 EYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQIL-----LGKEIKILKE 66 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 + ++ L D E P+S L++E DL D++ +G L E+ R F Q+ A+ Sbjct: 67 LQH--ENIVALYDVQELPNSVFLVMEYCNG-GDLADYLQAKGTLSEDTIRVFLHQIAAAM 123 Query: 156 RHCHNCGVLHRDIKDENILIDL-NRGE-------LKLIDFGSGALL-KDTVYTDFDGTRV 206 R H+ G++HRD+K +NIL+ NR + +K+ DFG L + + D G+ + Sbjct: 124 RILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAADLCGSPM 183 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD 245 Y PE I Y + A +WS+G ++Y + G PF+ + Sbjct: 184 YMAPEVIMSQHYDAK-ADLWSIGTVIYQCLVGKPPFQAN 221 >1FOT-A nrPDB Length = 318 Score = 91.7 bits (226), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 74/268 (27%), Positives = 134/268 (50%), Gaps = 20/268 (7%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 +Q+ LG+G FG V+ + A+K ++K+ + ++ + E ++L V+ Sbjct: 8 FQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTND---ERLMLSIVT 64 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 F +IR+ F+ +I++ E +LF + + +A+ + +V A+ + Sbjct: 65 HPF--IIRMWGTFQDAQQIFMIMDYIEG-GELFSLLRKSQRFPNPVAKFYAAEVCLALEY 121 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHR 217 H+ +++RD+K ENIL+D N G +K+ DFG + D YT GT Y PE + Sbjct: 122 LHSKDIIYRDLKPENILLDKN-GHIKITDFGFAKYVPDVTYT-LCGTPDYIAPEVVSTKP 179 Query: 218 YHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQV----FFRQRVSSECQHLI 267 Y+ +S WS GIL+Y+M+ G PF E+I+ ++ FF + V LI Sbjct: 180 YN-KSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRLI 238 Query: 268 RWCLALRPSD-RPTFEEIQNHPWMQDVL 294 L+ R + + E+++NHPW ++V+ Sbjct: 239 TRDLSQRLGNLQNGTEDVKNHPWFKEVV 266 >5JN2-A nrPDB Length = 525 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 88/318 (27%), Positives = 144/318 (45%), Gaps = 44/318 (13%) Query: 10 AHLRAAPCNDLHATKLAPG----KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLP-- 63 A P + LHAT PG +Y+ +LG G FG V I D + Sbjct: 40 AGTSGGPGDHLHAT---PGMFVQHSTAIFSDRYKGQRVLGKGSFGEV---ILCKDKITGQ 93 Query: 64 -VAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILER 122 A+K + K ++ + + R EV LLK++ +++L ++FE F L+ E Sbjct: 94 ECAVKVISKRQVKQKTDKESLLR---EVQLLKQLD--HPNIMKLYEFFEDKGYFYLVGE- 147 Query: 123 PEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNR--G 180 +LFD I R E A QVL + + H ++HRD+K EN+L++ Sbjct: 148 VYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDA 207 Query: 181 ELKLIDFG------SGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYD 234 +++IDFG + +KD + GT Y PE + H + VWS G++LY Sbjct: 208 NIRIIDFGLSTHFEASKKMKDKI-----GTAYYIAPEVL--HGTYDEKCDVWSTGVILYI 260 Query: 235 MVCGDIPF----EHD--EEIIRGQVFFR----QRVSSECQHLIRWCLALRPSDRPTFEEI 284 ++ G PF E+D +++ +G+ F ++VS + LIR L PS R + + Sbjct: 261 LLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISARDA 320 Query: 285 QNHPWMQDVLLPQETAEI 302 +H W+Q Q + ++ Sbjct: 321 LDHEWIQTYTKEQISVDV 338 >4B6L-A nrPDB Length = 281 Score = 91.7 bits (226), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 78/267 (29%), Positives = 119/267 (44%), Gaps = 16/267 (5%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 Y G LLG GGF Y A+K + + R++ + ++ E+ L + + Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQ---REKILNEIELHRDLQ 67 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 ++R FE D+ + LE + L R L E R + Q+L +++ Sbjct: 68 H--RHIVRFSHHFEDADNIYIFLELCS-RKSLAHIWKARHTLLEPEVRYYLRQILSGLKY 124 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPEWIRY 215 H G+LHRD+K N I N ELK+ DFG A L+ + GT Y PE + Sbjct: 125 LHQRGILHRDLKLGNFFITENM-ELKVGDFGLAARLEPPEQRKKTICGTPNYVAPE-VLL 182 Query: 216 HRYHGRSAAVWSLGILLYDMVCGDIPFEHDE--EIIR--GQVFFR--QRVSSECQHLIRW 269 + HG A VWSLG ++Y ++CG PFE + E R QV + +S + L+ Sbjct: 183 RQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAA 242 Query: 270 CLALRPSDRPTFEEIQNHPWMQDVLLP 296 L P DRP+ ++I H + P Sbjct: 243 ILRASPRDRPSIDQILRHDFFTKGYTP 269 >2X4F-A nrPDB Length = 373 Score = 91.3 bits (225), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 75/264 (28%), Positives = 127/264 (48%), Gaps = 25/264 (9%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 +LG G FG V+ + L +A K ++ + D E+ N E+ ++ ++ + Sbjct: 96 ILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKN------EISVMNQLD--HAN 147 Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW-QVLEAVRHCHNC 161 +I+L D FE + VL++E + +LFD I + EL F Q+ E +RH H Sbjct: 148 LIQLYDAFESKNDIVLVMEYVDG-GELFDRIIDESYNLTELDTILFMKQICEGIRHMHQM 206 Query: 162 GVLHRDIKDENIL-IDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPEWIRYHRY 218 +LH D+K ENIL ++ + ++K+IDFG K + + +F GT + PE + Y + Sbjct: 207 YILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNF-GTPEFLAPEVVNYD-F 264 Query: 219 HGRSAAVWSLGILLYDMVCGDIPF--EHDEEIIRGQVFFR--------QRVSSECQHLIR 268 +WS+G++ Y ++ G PF ++D E + + R Q +S E + I Sbjct: 265 VSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDEEFQDISEEAKEFIS 324 Query: 269 WCLALRPSDRPTFEEIQNHPWMQD 292 L S R + E HPW+ D Sbjct: 325 KLLIKEKSWRISASEALKHPWLSD 348 >4I6B-A nrPDB Length = 308 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 73/279 (26%), Positives = 126/279 (45%), Gaps = 16/279 (5%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +Y G LG GGF Y +++N A K + R+S + ++ E+ L + + Sbjct: 29 RYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQ---REKIDKEIELHRIL 85 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156 V++ +FE ++ ++LE + + + R L E R + Q++ ++ Sbjct: 86 HH--KHVVQFYHYFEDKENIYILLEYCS-RRSMAHILKARKVLTEPEVRYYLRQIVSGLK 142 Query: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT--DFDGTRVYSPPEWIR 214 + H +LHRD+K N I+ ELK+ DFG A L+ + GT Y PE + Sbjct: 143 YLHEQEILHRDLKLGNFFIN-ESMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLN 201 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPFEHD--EEIIRGQVFFRQRVSSE----CQHLIR 268 + HG + +W+LG ++Y M+ G PFE +E R R + S +HLI Sbjct: 202 -KQGHGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAPAKHLIA 260 Query: 269 WCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSL 307 L+ P DRP+ ++I H + P + H++ Sbjct: 261 SMLSKNPEDRPSLDDIIRHDFFTQGFTPDRLSSSCCHTV 299 >4WNO-A nrPDB Length = 287 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 62/211 (29%), Positives = 108/211 (51%), Gaps = 19/211 (9%) Query: 43 LLGSGGFGSVYSGI-RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS 101 L+G G F V+ G R + +L VA+K + K ++ + T + E+ +LK++ Sbjct: 25 LIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAK-----SQTLLGKEIKILKELKH--E 77 Query: 102 GVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNC 161 ++ L D+ E +S L++E DL D++ L E+ R F Q+ A+R H+ Sbjct: 78 NIVALYDFQEMANSVYLVMEYCNG-GDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSK 136 Query: 162 GVLHRDIKDENILI--------DLNRGELKLIDFGSGALLK-DTVYTDFDGTRVYSPPEW 212 G++HRD+K +NIL+ + N +K+ DFG L+ + + G+ +Y PE Sbjct: 137 GIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEV 196 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFE 243 I Y G+ A +WS+G ++Y + G PF+ Sbjct: 197 IMSQHYDGK-ADLWSIGTIVYQCLTGKAPFQ 226 >3SOA-A nrPDB Length = 444 Score = 89.7 bits (221), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 82/270 (30%), Positives = 121/270 (44%), Gaps = 26/270 (9%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRIS--DWGELPNGTRVPMEVVLLK 94 +YQ+ LG G F V ++V A + ++S D +L R+ LLK Sbjct: 12 EYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSARDHQKLEREARI---CRLLK 68 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 ++RL D LI + +LF+ I R E A Q+LEA Sbjct: 69 H-----PNIVRLHDSISEEGHHYLIFDLVTG-GELFEDIVAREYYSEADASHCIQQILEA 122 Query: 155 VRHCHNCGVLHRDIKDENILI--DLNRGELKLIDFGSGALL--KDTVYTDFDGTRVYSPP 210 V HCH GV+HR++K EN+L+ L +KL DFG + + + F GT Y P Sbjct: 123 VLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSP 182 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF----EHD--EEIIRGQVFFRQ----RVS 260 E +R Y G+ +W+ G++LY ++ G PF +H ++I G F V+ Sbjct: 183 EVLRKDPY-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVT 241 Query: 261 SECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 E + LI L + PS R T E HPW+ Sbjct: 242 PEAKDLINKMLTINPSKRITAAEALKHPWI 271 >6CMJ-A nrPDB Length = 321 Score = 89.4 bits (220), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 81/281 (28%), Positives = 130/281 (46%), Gaps = 40/281 (14%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDR-ISDWGEL--PNG--TRVPMEVV 91 QY + +G G +G V +DN A+K + K + I G P G +V E+ Sbjct: 35 QYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEIA 94 Query: 92 LLKKVSSGFSGVIRLLDWFERPDS----FVLILERPEPVQDLFDFITERGALQEELARSF 147 +LKK+ V++L++ + P+ V L PV + + L E+ AR + Sbjct: 95 ILKKLDH--PNVVKLVEVLDDPNEDHLYMVFELVNQGPVME----VPTLKPLSEDQARFY 148 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDF-------GSGALLKDTVYTD 200 F +++ + + H ++HRDIK N+L+ G +K+ DF GS ALL +TV Sbjct: 149 FQDLIKGIEYLHYQKIIHRDIKPSNLLVG-EDGHIKIADFGVSNEFKGSDALLSNTV--- 204 Query: 201 FDGTRVYSPPEWIRYHR--YHGRSAAVWSLGILLYDMVCGDIPFEHDEEI------IRGQ 252 GT + PE + R + G++ VW++G+ LY V G PF DE I I+ Q Sbjct: 205 --GTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF-MDERIMCLHSKIKSQ 261 Query: 253 VFF---RQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 + ++ + + LI L P R EI+ HPW+ Sbjct: 262 ALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 302 >3ORZ-A nrPDB Length = 316 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 69/272 (25%), Positives = 130/272 (47%), Gaps = 24/272 (8%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 ++ G +LG G F +V ++ + AIK +EK I ++P TR E ++ ++ Sbjct: 39 FKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTR---ERDVMSRLD 95 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 F ++L F+ + L + +L +I + G+ E R + +++ A+ + Sbjct: 96 HPF--FVKLYFCFQDDEKLYFGLSYAKN-GELLKYIRKIGSFDETCTRFYTAEIVSALEY 152 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL----KDTVYTDFDGTRVYSPPEWI 213 H G++HRD+K ENIL++ + +++ DFG+ +L K F GT Y PE + Sbjct: 153 LHGKGIIHRDLKPENILLNEDM-HIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELL 211 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRVSSECQHLI 267 + +S+ +W+LG ++Y +V G PF E II+ + F ++ + + L+ Sbjct: 212 T-EKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARDLV 270 Query: 268 RWCLALRPSDRPTFEEIQN------HPWMQDV 293 L L + R EE++ HP+ + V Sbjct: 271 EKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 302 >1NY3-A nrPDB Length = 400 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 71/221 (32%), Positives = 104/221 (47%), Gaps = 30/221 (13%) Query: 103 VIRLLDWFER---PDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLEAVRH 157 ++R++D +E +LI+ +LF I +RG A E A + EA+++ Sbjct: 117 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 176 Query: 158 CHNCGVLHRDIKDENILIDLNRGE--LKLIDFGSGALLKDTVYTDFDGTRVYSP----PE 211 H+ + HRD+K EN+L R LKL DFG K+T + T Y+P PE Sbjct: 177 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFG---FAKETTSHNSLTTPCYTPYYVAPE 233 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE----------EIIRGQVFFRQ---- 257 + +Y +S +WSLG+++Y ++CG PF + I GQ F Sbjct: 234 VLGPEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 292 Query: 258 RVSSECQHLIRWCLALRPSDRPTFEEIQNHPW-MQDVLLPQ 297 VS E + LIR L P+ R T E NHPW MQ +PQ Sbjct: 293 EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 333 >3KN6-A nrPDB Length = 325 Score = 89.0 bits (219), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 77/275 (28%), Positives = 125/275 (45%), Gaps = 43/275 (15%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 LG G F + N A+K + K ++ E+ LK + G + Sbjct: 19 LGEGSFSICRKCVHKKSNQAFAVKIISKRMEAN---------TQKEITALK-LCEGHPNI 68 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGV 163 ++L + F L++E +LF+ I ++ E A +++ AV H H+ GV Sbjct: 69 VKLHEVFHDQLHTFLVMELLNG-GELFERIKKKKHFSETEASYIMRKLVSAVSHMHDVGV 127 Query: 164 LHRDIKDENILI-DLNRG-ELKLIDFGSGAL-------LKDTVYTDFDGTRVYSPPEWIR 214 +HRD+K EN+L D N E+K+IDFG L LK + T Y+ PE + Sbjct: 128 VHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPCF-----TLHYAAPELLN 182 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPFE-HD------------EEIIRGQVFFR----Q 257 + Y S +WSLG++LY M+ G +PF+ HD ++I +G F + Sbjct: 183 QNGY-DESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIKKGDFSFEGEAWK 241 Query: 258 RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 VS E + LI+ L + P+ R ++ + W+QD Sbjct: 242 NVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQD 276 >3MA6-A nrPDB Length = 298 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 80/282 (28%), Positives = 132/282 (46%), Gaps = 37/282 (13%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLP---VAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 +Y+ +LG G FG V I D + A+K + K ++ + + R EV LL Sbjct: 33 RYKGQRVLGKGSFGEV---ILCKDKITGQECAVKVISKRQVKQKTDKESLLR---EVQLL 86 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 K++ +++L ++FE F L+ E +LFD I R E A QVL Sbjct: 87 KQLDH--PNIMKLYEFFEDKGYFYLVGE-VYTGGELFDEIISRKRFSEVDAARIIRQVLS 143 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNR--GELKLIDFG------SGALLKDTVYTDFDGTR 205 + + H ++HRD+K EN+L++ +++IDFG + +KD + GT Sbjct: 144 GITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASKKMKDKI-----GTA 198 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF----EHD--EEIIRGQVFFR--- 256 Y PE + H + VWS G++LY ++ G PF E+D +++ +G+ F Sbjct: 199 YYIAPEVL--HGTYDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEKGKYTFELPQ 256 Query: 257 -QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQ 297 ++VS + LIR L PS R + + +H W+Q Q Sbjct: 257 WKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQ 298 >3IS5-A nrPDB Length = 285 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 73/268 (27%), Positives = 124/268 (46%), Gaps = 34/268 (12%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVV-----LLKKVSS 98 LGSG FG V+ S L IK + KDR ++VPME + +LK + Sbjct: 30 LGSGAFGDVHLVEERSSGLERVIKTINKDR----------SQVPMEQIEAEIEVLKSLDH 79 Query: 99 GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG---ALQEELARSFFWQVLEAV 155 +I++ + FE + +++E E + L ++ + AL E Q++ A+ Sbjct: 80 --PNIIKIFEVFEDYHNMYIVMETCEGGELLERIVSAQARGKALSEGYVAELMKQMMNAL 137 Query: 156 RHCHNCGVLHRDIKDENILIDLN--RGELKLIDFGSGALLK-DTVYTDFDGTRVYSPPEW 212 + H+ V+H+D+K ENIL +K+IDFG L K D T+ GT +Y PE Sbjct: 138 AYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTALYMAPEV 197 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD--EEIIRGQVFFRQRVSSECQ------ 264 + R +WS G+++Y ++ G +PF EE+ + + + EC+ Sbjct: 198 FK--RDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKATYKEPNYAVECRPLTPQA 255 Query: 265 -HLIRWCLALRPSDRPTFEEIQNHPWMQ 291 L++ L P RP+ ++ +H W + Sbjct: 256 VDLLKQMLTKDPERRPSAAQVLHHEWFK 283 >2OZA-A nrPDB Length = 356 Score = 88.6 bits (218), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 71/221 (32%), Positives = 104/221 (47%), Gaps = 30/221 (13%) Query: 103 VIRLLDWFER---PDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLEAVRH 157 ++R++D +E +LI+ +LF I +RG A E A + EA+++ Sbjct: 73 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 132 Query: 158 CHNCGVLHRDIKDENILIDLNRGE--LKLIDFGSGALLKDTVYTDFDGTRVYSP----PE 211 H+ + HRD+K EN+L R LKL DFG K+T + T Y+P PE Sbjct: 133 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFG---FAKETTSHNSLTTPCYTPYYVAPE 189 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE----------EIIRGQVFFRQ---- 257 + +Y +S +WSLG+++Y ++CG PF + I GQ F Sbjct: 190 VLGPEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWS 248 Query: 258 RVSSECQHLIRWCLALRPSDRPTFEEIQNHPW-MQDVLLPQ 297 VS E + LIR L P+ R T E NHPW MQ +PQ Sbjct: 249 EVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 289 >3F3Z-A nrPDB Length = 277 Score = 88.2 bits (217), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 78/280 (27%), Positives = 119/280 (42%), Gaps = 24/280 (8%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 G K + Y + +G G +G V ++ + A K + K + D R Sbjct: 1 GSTKGDINQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVD------RFK 54 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSF 147 E+ ++K + +IRL + FE L++E +LF+ + + +E A Sbjct: 55 QEIEIMKSLDH--PNIIRLYETFEDNTDIYLVMELCTG-GELFERVVHKRVFRESDAARI 111 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILI--DLNRGELKLIDFGSGALLK-DTVYTDFDGT 204 VL AV +CH V HRD+K EN L D LKLIDFG A K + GT Sbjct: 112 MKDVLSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGT 171 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE--HDEEII----RGQVFFRQR 258 Y P+ + +G WS G+++Y ++CG PF D E++ G F ++ Sbjct: 172 PYYVSPQVL--EGLYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEK 229 Query: 259 ----VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVL 294 VS + + LIR L P R T + H W + L Sbjct: 230 DWLNVSPQAESLIRRLLTKSPKQRITSLQALEHEWFEKQL 269 >2VN9-A nrPDB Length = 301 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 78/273 (28%), Positives = 122/273 (44%), Gaps = 26/273 (9%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRIS--DWGELPNGTRVPMEVV 91 + +YQ+ LG G F V +++ A K + ++S D +L R+ Sbjct: 2 MTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARI---CR 58 Query: 92 LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQV 151 LLK ++RL D L+ + +LF+ I R E A Q+ Sbjct: 59 LLKH-----PNIVRLHDSISEEGFHYLVFDLVTG-GELFEDIVAREYYSEADASHCIQQI 112 Query: 152 LEAVRHCHNCGVLHRDIKDENILIDLNR--GELKLIDFGSGALLK--DTVYTDFDGTRVY 207 LE+V HCH G++HRD+K EN+L+ +KL DFG ++ + F GT Y Sbjct: 113 LESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGY 172 Query: 208 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF----EHD--EEIIRGQVFFRQ---- 257 PE +R Y G+ +W+ G++LY ++ G PF +H ++I G F Sbjct: 173 LSPEVLRKDPY-GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWD 231 Query: 258 RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 V+ E + LI L + P+ R T E HPW+ Sbjct: 232 TVTPEAKDLINKMLTINPAKRITASEALKHPWI 264 >5N23-A nrPDB Length = 352 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 78/301 (25%), Positives = 135/301 (44%), Gaps = 26/301 (8%) Query: 4 SKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLP 63 S+ S+ A D +P + L+ Q++ LG+G FG V Sbjct: 11 SEQESVKEFLAKAKEDFLKKWESPAQNTAHLD-QFERIRTLGTGSFGRVMLVKHKETGNH 69 Query: 64 VAIKHVEKDRISDWGELP---NGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL 120 A+K ++K ++ ++ N R+ V F +++L F+ + ++L Sbjct: 70 YAMKILDKQKVVKLKQIEHTLNEKRIQQAV--------NFPFLVKLEFSFKDNSNLYMVL 121 Query: 121 ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG 180 E P ++F + G E AR + Q++ + H+ +++RD+K EN+LID +G Sbjct: 122 EYA-PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-QQG 179 Query: 181 ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI 240 +K+ DFG +K GT Y PE I Y+ ++ W+LG+L+Y+M G Sbjct: 180 YIKVADFGFAKRVKGRTPWTLCGTPEYLAPEIILSKGYN-KAVDWWALGVLIYEMAAGYP 238 Query: 241 PFEHD------EEIIRGQVFFRQRVSSECQHLIRWCLALRPSDR-----PTFEEIQNHPW 289 PF D E+I+ G+V F SS+ + L+R L + + R +I+NH W Sbjct: 239 PFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKW 298 Query: 290 M 290 Sbjct: 299 F 299 >3KA0-A nrPDB Length = 320 Score = 86.7 bits (213), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 71/223 (31%), Positives = 103/223 (46%), Gaps = 34/223 (15%) Query: 103 VIRLLDWFER---PDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLEAVRH 157 ++R++D +E +LI+ +LF I +RG A E A + EA+++ Sbjct: 71 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 130 Query: 158 CHNCGVLHRDIKDENILIDLNRGE--LKLIDFG------SGALLKDTVYTDFDGTRVYSP 209 H+ + HRD+K EN+L R LKL DFG S L + YT + Y Sbjct: 131 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTEPCYTPY-----YVA 185 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE----------EIIRGQVFFRQ-- 257 PE + +Y +S +WSLG+++Y ++CG PF + I GQ F Sbjct: 186 PEVLGPEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPE 244 Query: 258 --RVSSECQHLIRWCLALRPSDRPTFEEIQNHPW-MQDVLLPQ 297 VS E + LIR L P+ R T E NHPW MQ +PQ Sbjct: 245 WSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 287 >3TAC-A nrPDB Length = 361 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 57/206 (27%), Positives = 101/206 (49%), Gaps = 17/206 (8%) Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA---LQEELARSFFWQVLEAVRHCH 159 ++ LL+ + ++ E + F+ + A E +A + Q+LEA+R+CH Sbjct: 90 IVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCH 149 Query: 160 NCGVLHRDIKDENILI--DLNRGELKLIDFGSGALLKDT--VYTDFDGTRVYSPPEWIRY 215 + ++HRD+K +L+ N +KL FG L ++ V GT + PE ++ Sbjct: 150 DNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKR 209 Query: 216 HRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE-----IIRGQVFFRQR----VSSECQHL 266 Y G+ VW G++L+ ++ G +PF +E II+G+ R +S + L Sbjct: 210 EPY-GKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDL 268 Query: 267 IRWCLALRPSDRPTFEEIQNHPWMQD 292 +R L L P++R T E NHPW+++ Sbjct: 269 VRRMLMLDPAERITVYEALNHPWLKE 294 >2BRG-A nrPDB Length = 297 Score = 85.5 bits (210), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 71/275 (25%), Positives = 118/275 (42%), Gaps = 22/275 (8%) Query: 33 PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVL 92 P + + LG G +G V + VA+K V+ R D E + E+ + Sbjct: 4 PFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPE-----NIKKEICI 58 Query: 93 LKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 K ++ V++ + L LE +LFD I + E A+ FF Q++ Sbjct: 59 NKMLNH--ENVVKFYGHRREGNIQYLFLEYCSG-GELFDRIEPDIGMPEPDAQRFFHQLM 115 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL----KDTVYTDFDGTRVYS 208 V + H G+ HRDIK EN+L+D R LK+ DFG + ++ + GT Y Sbjct: 116 AGVVYLHGIGITHRDIKPENLLLD-ERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYV 174 Query: 209 PPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ---------RV 259 PE ++ +H VWS GI+L M+ G++P++ + + +++ ++ Sbjct: 175 APELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKI 234 Query: 260 SSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVL 294 S L+ L PS R T +I+ W L Sbjct: 235 DSAPLALLHKILVENPSARITIPDIKKDRWYNKPL 269 >4RLP-A nrPDB Length = 288 Score = 85.1 bits (209), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 74/267 (27%), Positives = 130/267 (48%), Gaps = 23/267 (8%) Query: 43 LLGSGGFGSVYSGIRVS---DNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 99 +LG GG+G V+ +V+ A+K ++K I + T+ E +L++V Sbjct: 12 VLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKA--ERNILEEVKHP 69 Query: 100 FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 159 F ++ L+ F+ LILE +LF + G E+ A + ++ A+ H H Sbjct: 70 F--IVDLIYAFQTGGKLYLILEYLSG-GELFMQLEREGIFMEDTACFYLAEISMALGHLH 126 Query: 160 NCGVLHRDIKDENILIDLNRGELKLIDFG--SGALLKDTVYTDFDGTRVYSPPEWIRYHR 217 G+++RD+K ENI+++ ++G +KL DFG ++ TV F GT Y PE I Sbjct: 127 QKGIIYRDLKPENIMLN-HQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPE-ILMRS 184 Query: 218 YHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRWCL 271 H R+ WSLG L+YDM+ G PF + ++I++ ++ ++ E + L++ L Sbjct: 185 GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLL 244 Query: 272 ALRPSDR-----PTFEEIQNHPWMQDV 293 + R E+Q HP+ + + Sbjct: 245 KRNAASRLGAGPGDAGEVQAHPFFRHI 271 >4WB7-A nrPDB Length = 405 Score = 85.1 bits (209), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 71/265 (26%), Positives = 129/265 (48%), Gaps = 20/265 (7%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 Q++ LG+G FG V A+K ++K ++ ++ + E +L+ V Sbjct: 97 QFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLN---EKRILQAV 153 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156 + F +++L F+ + +++E P ++F + G E AR + Q++ Sbjct: 154 N--FPFLVKLEFSFKDNSNLYMVMEYV-PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFE 210 Query: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYH 216 + H+ +++RD+K EN+LID +G +++ DFG +K +T GT Y PE I Sbjct: 211 YLHSLDLIYRDLKPENLLID-QQGYIQVTDFGFAKRVKGRTWT-LCGTPEYLAPEIILSK 268 Query: 217 RYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRWC 270 Y+ ++ W+LG+L+Y+M G PF D E+I+ G+V F SS+ + L+R Sbjct: 269 GYN-KAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNL 327 Query: 271 LALRPSDR-----PTFEEIQNHPWM 290 L + + R +I+NH W Sbjct: 328 LQVDLTKRFGNLKNGVNDIKNHKWF 352 >6E2O-A nrPDB Length = 295 Score = 85.1 bits (209), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 71/253 (28%), Positives = 122/253 (48%), Gaps = 28/253 (11%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM--EVVLLKKVSSGF 100 +LG G +G VY+G +S+ + +AIK + +R S + + P+ E+ L K + Sbjct: 29 VLGKGTYGIVYAGRDLSNQVRIAIKEI-PERDSRYSQ-------PLHEEIALHKHLKH-- 78 Query: 101 SGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER-GALQEELARSFFW--QVLEAVRH 157 +++ L F + F+ I P L + + G L++ F+ Q+LE +++ Sbjct: 79 KNIVQYLGSFSE-NGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKY 137 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPEWI-R 214 H+ ++HRDIK +N+LI+ G LK+ DFG+ L + F GT Y PE I + Sbjct: 138 LHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDK 197 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPF----EHDEEIIRGQVF-----FRQRVSSECQH 265 R +G++A +WSLG + +M G PF E + + +F + +S+E + Sbjct: 198 GPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKA 257 Query: 266 LIRWCLALRPSDR 278 I C P R Sbjct: 258 FILKCFEPDPDKR 270 >5X3F-B nrPDB Length = 393 Score = 84.7 bits (208), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 76/297 (25%), Positives = 137/297 (46%), Gaps = 21/297 (7%) Query: 5 KINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPV 64 K+N + A D P + L+ Q+ LG+G FG V Sbjct: 54 KLNDVQAFLAKAKEDFLKKWETPSQNTAQLD-QFDRIKTLGTGSFGRVMLVKHKESGNHY 112 Query: 65 AIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPE 124 A+K ++K ++ ++ + E +L+ V+ F +++L F+ + +++E Sbjct: 113 AMKILDKQKVVKLKQIEHTLN---EKRILQAVN--FPFLVKLEFSFKDNSNLYMVMEYVA 167 Query: 125 PVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKL 184 ++F + G E AR + Q++ + H+ +++RD+K EN+LID +G +++ Sbjct: 168 G-GEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYIQV 225 Query: 185 IDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH 244 DFG +K +T GT Y PE I Y+ ++ W+LG+L+Y+M G PF Sbjct: 226 TDFGFAKRVKGRTWT-LCGTPEYLAPEIILSKGYN-KAVDWWALGVLIYEMAAGYPPFFA 283 Query: 245 D------EEIIRGQVFFRQRVSSECQHLIRWCLALRPSDR-----PTFEEIQNHPWM 290 D E+I+ G+V F SS+ + L+R L + + R +I+NH W Sbjct: 284 DQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWF 340 >5YV8-A nrPDB Length = 298 Score = 84.3 bits (207), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 79/297 (26%), Positives = 131/297 (44%), Gaps = 55/297 (18%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGEL--------------- 80 +QY + +G G +G V +DN A+K + K ++ Sbjct: 13 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 72 Query: 81 ---PNG--TRVPMEVVLLKKVSSGFSGVIRLLDWFERPDS----FVLILERPEPVQDLFD 131 P G +V E+ +LKK+ V++L++ + P+ V L PV + Sbjct: 73 CIQPRGPIEQVYQEIAILKKLDH--PNVVKLVEVLDDPNEDHLYMVFELVNQGPVME--- 127 Query: 132 FITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDF---- 187 + L E+ AR +F +++ + + H ++HRDIK N+L+ + G +K+ DF Sbjct: 128 -VPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGED-GHIKIADFGVSN 185 Query: 188 ---GSGALLKDTVYTDFDGTRVYSPPEWIRYHR--YHGRSAAVWSLGILLYDMVCGDIPF 242 GS ALL +TV GT + PE + R + G++ VW++G+ LY V G PF Sbjct: 186 EFKGSDALLSNTV-----GTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPF 240 Query: 243 EHDEEI------IRGQVFF---RQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 DE I I+ Q + ++ + + LI L P R EI+ HPW+ Sbjct: 241 -MDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 296 >4L42-A nrPDB Length = 346 Score = 84.3 bits (207), Expect = 6e-17, Method: Compositional matrix adjust. Identities = 74/267 (27%), Positives = 130/267 (48%), Gaps = 23/267 (8%) Query: 43 LLGSGGFGSVYSGIRVS---DNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 99 +LG GG+G V+ +V+ A+K ++K I + T+ E +L++V Sbjct: 25 VLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKA--ERNILEEVKHP 82 Query: 100 FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 159 F ++ L+ F+ LILE +LF + G E+ A + ++ A+ H H Sbjct: 83 F--IVDLIYAFQTGGKLYLILEYLSG-GELFMQLEREGIFMEDTACFYLAEISMALGHLH 139 Query: 160 NCGVLHRDIKDENILIDLNRGELKLIDFG--SGALLKDTVYTDFDGTRVYSPPEWIRYHR 217 G+++RD+K ENI+++ ++G +KL DFG ++ TV F GT Y PE I Sbjct: 140 QKGIIYRDLKPENIMLN-HQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPE-ILMRS 197 Query: 218 YHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRWCL 271 H R+ WSLG L+YDM+ G PF + ++I++ ++ ++ E + L++ L Sbjct: 198 GHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLL 257 Query: 272 ALRPSDR-----PTFEEIQNHPWMQDV 293 + R E+Q HP+ + + Sbjct: 258 KRNAASRLGAGPGDAGEVQAHPFFRHI 284 >6GVJ-A nrPDB Length = 429 Score = 84.0 bits (206), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 80/279 (28%), Positives = 127/279 (45%), Gaps = 36/279 (12%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT--RVPMEVVLLKK 95 Y + +GSGG V+ + + AIK+V + E N T E+ L K Sbjct: 146 YSILKQIGSGGSSKVFQVLNEKKQI-YAIKYV------NLEEADNQTLDSYRNEIAYLNK 198 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 + +IRL D +E D ++ ++ + DL ++ ++ ++ +S++ +LEAV Sbjct: 199 LQQHSDKIIRLYD-YEITDQYIYMVMECGNI-DLNSWLKKKKSIDPWERKSYWKNMLEAV 256 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFD---GTRVYSPPE 211 H G++H D+K N LI G LKLIDFG + + DT D GT Y PPE Sbjct: 257 HTIHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPE 314 Query: 212 WIR---YHRYHGRSAA-------VWSLGILLYDMVCGDIPFEHDEEIIRG---------Q 252 I+ R +G+S + VWSLG +LY M G PF+ I + Sbjct: 315 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHE 374 Query: 253 VFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 + F + Q +++ CL P R + E+ HP++Q Sbjct: 375 IEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 413 >1VZO-A nrPDB Length = 355 Score = 84.0 bits (206), Expect = 8e-17, Method: Compositional matrix adjust. Identities = 82/298 (27%), Positives = 142/298 (47%), Gaps = 28/298 (9%) Query: 18 NDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLP---VAIKHVEKDRI 74 ++L L EK +E+ +++ +LG+G +G V+ ++S + A+K ++K I Sbjct: 37 HELRTANLTGHAEKVGIEN-FELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATI 95 Query: 75 SDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT 134 + TR +V L S F ++ L F+ LIL+ +LF ++ Sbjct: 96 VQKAKTTEHTRTERQV-LEHIRQSPF--LVTLHYAFQTETKLHLILDYING-GELFTHLS 151 Query: 135 ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALL 193 +R E + + +++ A+ H H G+++RDIK ENIL+D N G + L DFG S + Sbjct: 152 QRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSN-GHVVLTDFGLSKEFV 210 Query: 194 KDTV--YTDFDGTRVYSPPEWIR-YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE--- 247 D DF GT Y P+ +R H ++ WSLG+L+Y+++ G PF D E Sbjct: 211 ADETERAYDFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNS 270 Query: 248 -------IIRGQVFFRQRVSSECQHLIRWCLALRPSDR-----PTFEEIQNHPWMQDV 293 I++ + + Q +S+ + LI+ L P R +EI+ H + Q + Sbjct: 271 QAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKI 328 >3HMP-A nrPDB Length = 342 Score = 83.6 bits (205), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 80/279 (28%), Positives = 127/279 (45%), Gaps = 36/279 (12%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT--RVPMEVVLLKK 95 Y + +GSGG V+ + + AIK+V + E N T E+ L K Sbjct: 58 YSILKQIGSGGSSKVFQVLNEKKQI-YAIKYV------NLEEADNQTLDSYRNEIAYLNK 110 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 + +IRL D +E D ++ ++ + DL ++ ++ ++ +S++ +LEAV Sbjct: 111 LQQHSDKIIRLYD-YEITDQYIYMVMECGNI-DLNSWLKKKKSIDPWERKSYWKNMLEAV 168 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFD---GTRVYSPPE 211 H G++H D+K N LI G LKLIDFG + + DT D GT Y PPE Sbjct: 169 HTIHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPE 226 Query: 212 WIR---YHRYHGRSAA-------VWSLGILLYDMVCGDIPFEHDEEIIRG---------Q 252 I+ R +G+S + VWSLG +LY M G PF+ I + Sbjct: 227 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHE 286 Query: 253 VFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 + F + Q +++ CL P R + E+ HP++Q Sbjct: 287 IEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 325 >4RGJ-A nrPDB Length = 520 Score = 83.2 bits (204), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 81/313 (25%), Positives = 140/313 (44%), Gaps = 37/313 (11%) Query: 18 NDLHATKLAPG----KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDR 73 N + +KL PG QY+ +LG G FG V AIK + K Sbjct: 38 NSFNNSKLRPGMFIQNSNVVFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKH 97 Query: 74 ISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI 133 + + + R EV LLK + +++L ++FE + + L+ + +LFD I Sbjct: 98 VKRKTDKESLLR---EVELLKMLDH--INIMKLYEFFEDNNYYYLVSDVYTG-GELFDEI 151 Query: 134 TERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE---LKLIDFG-- 188 R E A Q+L + + H V+HRD+K ENIL++ E +K+IDFG Sbjct: 152 ISRKRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLS 211 Query: 189 ----SGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF-- 242 +KD + GT Y P+ + H + +WS G++LY ++ G PF Sbjct: 212 THFEYSKKMKDKI-----GTAYYIAPDVL--HGTYDEKCDIWSCGVILYILLSGCPPFNG 264 Query: 243 --EHD--EEIIRGQVFFR----QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVL 294 E+D +++ G+ F +++S + + LI+ L + R + + H W++ ++ Sbjct: 265 SNEYDILKKVEAGKYTFDLPQFKKISDKAKDLIKKMLMYTSAVRISARDALEHEWIK-MM 323 Query: 295 LPQETAEIHLHSL 307 ++ I + SL Sbjct: 324 TSKDNLNIDIPSL 336 >2WTK-C nrPDB Length = 305 Score = 82.8 bits (203), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 74/282 (26%), Positives = 126/282 (44%), Gaps = 24/282 (8%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNG-TRVPMEVVL 92 L +Y +G LLG G +G V V D+ + + V+ + +PNG V E+ L Sbjct: 3 LIGKYLMGDLLGEGSYGKVK---EVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQL 59 Query: 93 LKKVSSGFSGVIRLLD--WFERPDSFVLILERPE-PVQDLFDFITERGALQEELARSFFW 149 L+++ VI+L+D + E +++E +Q++ D + E+ A +F Sbjct: 60 LRRLRH--KNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVCQAHGYFC 116 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL-----KDTVYTDFDGT 204 Q+++ + + H+ G++H+DIK N+L+ G LK+ G L DT T G+ Sbjct: 117 QLIDGLEYLHSQGIVHKDIKPGNLLLTTG-GTLKISALGVAEALHPFAADDTCRTS-QGS 174 Query: 205 RVYSPPEWIR-YHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQ 257 + PPE + G +WS G+ LY++ G PFE D E I +G Sbjct: 175 PAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPG 234 Query: 258 RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQET 299 L++ L P+ R + +I+ H W + P E Sbjct: 235 DCGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEA 276 >5AP3-A nrPDB Length = 313 Score = 82.4 bits (202), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 80/279 (28%), Positives = 127/279 (45%), Gaps = 36/279 (12%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT--RVPMEVVLLKK 95 Y + +GSGG V+ + + AIK+V + E N T E+ L K Sbjct: 30 YSILKQIGSGGSSKVFQVLNEKKQI-YAIKYV------NLEEADNQTLDSYRNEIAYLNK 82 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 + +IRL D +E D ++ ++ + DL ++ ++ ++ +S++ +LEAV Sbjct: 83 LQQHSDKIIRLYD-YEITDQYIYMVMECGNI-DLNGWLKKKKSIDPWERKSYWKNMLEAV 140 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFD---GTRVYSPPE 211 H G++H D+K N LI G LKLIDFG + + DT D GT Y PPE Sbjct: 141 HTIHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPE 198 Query: 212 WIR---YHRYHGRSAA-------VWSLGILLYDMVCGDIPFEHDEEIIRG---------Q 252 I+ R +G+S + VWSLG +LY M G PF+ I + Sbjct: 199 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHE 258 Query: 253 VFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 + F + Q +++ CL P R + E+ HP++Q Sbjct: 259 IEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 297 >2V7O-A nrPDB Length = 336 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 75/269 (27%), Positives = 120/269 (44%), Gaps = 26/269 (9%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRIS--DWGELPNGTRVPMEVVLLKK 95 YQ+ LG G F V ++ + A K + ++S D +L R+ LLK Sbjct: 33 YQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSARDHQKLEREARI---CRLLKH 89 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 ++RL D L+ + +LF+ I R E A Q+LE+V Sbjct: 90 -----PNIVRLHDSISEEGFHYLVFDLVTG-GELFEDIVAREYYSEADASHCIHQILESV 143 Query: 156 RHCHNCGVLHRDIKDENILI--DLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPE 211 H H ++HRD+K EN+L+ +KL DFG ++ + F GT Y PE Sbjct: 144 NHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPE 203 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPF----EHD--EEIIRGQVFFRQ----RVSS 261 +R Y G+ +W+ G++LY ++ G PF +H ++I G F V+ Sbjct: 204 VLRKDPY-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTP 262 Query: 262 ECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 E ++LI L + P+ R T ++ HPW+ Sbjct: 263 EAKNLINQMLTINPAKRITADQALKHPWV 291 >2WQN-A nrPDB Length = 310 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 72/259 (27%), Positives = 114/259 (44%), Gaps = 22/259 (8%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 + +++ +G G F VY + D +PVA+K V+ I D + E+ LLK+ Sbjct: 32 ANFRIEKKIGRGQFSEVYRAACLLDGVPVALKKVQ---IFDLMDAKARADCIKEIDLLKQ 88 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEP---VQDLFDFITERGALQEELARSFFWQVL 152 ++ VI+ F + ++LE + + + F ++ + E +F Q+ Sbjct: 89 LNH--PNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLC 146 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYTDFDGTRVYSPP 210 A+ H H+ V+HRDIK N+ I G +KL D G G K T GT Y P Sbjct: 147 SALEHMHSRRVMHRDIKPANVFITAT-GVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSP 205 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRG------QVFF----RQRVS 260 E I + Y+ +S +WSLG LLY+M PF D+ + Q + S Sbjct: 206 ERIHENGYNFKS-DIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYS 264 Query: 261 SECQHLIRWCLALRPSDRP 279 E + L+ C+ P RP Sbjct: 265 EELRQLVNMCINPDPEKRP 283 >3FXW-A nrPDB Length = 336 Score = 82.0 bits (201), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 67/224 (29%), Positives = 103/224 (45%), Gaps = 25/224 (11%) Query: 97 SSGFSGVIRLLDWFER----PDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQ 150 +SG ++ +LD +E ++I+E E +LF I ERG A E A Sbjct: 78 ASGGPHIVCILDVYENMHHGKRCLLIIMECMEG-GELFSRIQERGDQAFTEREAAEIMRD 136 Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGE--LKLIDFGSGALLKDTVYTDFDGTRVYS 208 + A++ H+ + HRD+K EN+L + LKL DFG T Y Sbjct: 137 IGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNALQTPCYTPYYV 196 Query: 209 PPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD----------EEIIRGQVFFRQ- 257 PE + +Y +S +WSLG+++Y ++CG PF + I GQ F Sbjct: 197 APEVLGPEKY-DKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNP 255 Query: 258 ---RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM-QDVLLPQ 297 VS + + LIR L P++R T + NHPW+ Q +++PQ Sbjct: 256 EWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQ 299 >4YZB-A nrPDB Length = 491 Score = 81.6 bits (200), Expect = 3e-16, Method: Compositional matrix adjust. Identities = 61/207 (29%), Positives = 98/207 (47%), Gaps = 26/207 (12%) Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCG 162 +++L ++FE F L+ E +LFD I R E A QVL + + H Sbjct: 92 IMKLYEFFEDKGYFYLVTE-VYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNK 150 Query: 163 VLHRDIKDENILIDLNR--GELKLIDFG------SGALLKDTVYTDFDGTRVYSPPEWIR 214 ++HRD+K EN+L++ R +++IDFG S +KD + GT Y PE + Sbjct: 151 IVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKI-----GTAYYIAPEVL- 204 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFR----QRVSSECQ 264 H + VWS G++LY ++ G PF E + +G+ F ++VS + Sbjct: 205 -HGTYDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVSEPAK 263 Query: 265 HLIRWCLALRPSDRPTFEEIQNHPWMQ 291 LIR LA P+ R + + H W++ Sbjct: 264 DLIRKMLAYVPTMRISARDALEHEWLK 290 >2JDO-A nrPDB Length = 342 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 71/249 (28%), Positives = 119/249 (47%), Gaps = 26/249 (10%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 LLG G FG V + A+K + K+ I E+ + E +L+ F Sbjct: 17 LLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTV---TESRVLQNTRHPFLT 73 Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCG 162 ++ F+ D ++E + F ER EE AR + +++ A+ + H+ Sbjct: 74 ALKYA--FQTHDRLCFVMEYANGGELFFHLSRER-VFTEERARFYGAEIVSALEYLHSRD 130 Query: 163 VLHRDIKDENILIDLNRGELKLIDFG-------SGALLKDTVYTDFDGTRVYSPPEWIRY 215 V++RDIK EN+++D + G +K+ DFG GA +K F GT Y PE + Sbjct: 131 VVYRDIKLENLMLDKD-GHIKITDFGLCKEGISDGATMK-----TFCGTPEYLAPEVLED 184 Query: 216 HRYHGRSAAVWSLGILLYDMVCGDIPF---EHD---EEIIRGQVFFRQRVSSECQHLIRW 269 + Y GR+ W LG+++Y+M+CG +PF +H+ E I+ ++ F + +S E + L+ Sbjct: 185 NDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAG 243 Query: 270 CLALRPSDR 278 L P R Sbjct: 244 LLKKDPKQR 252 >2ZMD-A nrPDB Length = 390 Score = 81.6 bits (200), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 79/279 (28%), Positives = 126/279 (45%), Gaps = 36/279 (12%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT--RVPMEVVLLKK 95 Y + +GSGG V+ + + AIK+V + E N T E+ L K Sbjct: 58 YSILKQIGSGGSSKVFQVLNEKKQI-YAIKYV------NLEEADNQTLDSYRNEIAYLNK 110 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 + +IRL D +E D ++ ++ + DL ++ ++ ++ +S++ +LEAV Sbjct: 111 LQQHSDKIIRLYD-YEITDQYIYMVMECGNI-DLNSWLKKKKSIDPWERKSYWKNMLEAV 168 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFD---GTRVYSPPE 211 H G++H D+K N LI G LKLIDFG + + DT D G Y PPE Sbjct: 169 HTIHQHGIVHSDLKPANFLI--VDGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPE 226 Query: 212 WIR---YHRYHGRSAA-------VWSLGILLYDMVCGDIPFEHDEEIIRG---------Q 252 I+ R +G+S + VWSLG +LY M G PF+ I + Sbjct: 227 AIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHE 286 Query: 253 VFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 + F + Q +++ CL P R + E+ HP++Q Sbjct: 287 IEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQ 325 >2BDW-A nrPDB Length = 362 Score = 81.3 bits (199), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 69/269 (25%), Positives = 121/269 (44%), Gaps = 25/269 (9%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRIS--DWGELPNGTRVPMEVVLLK 94 Y V LG G F V + + L A K + ++S D+ +L R+ ++ Sbjct: 30 NYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKL---- 85 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 ++RL D + +SF ++ +LF+ I R E A Q+LE+ Sbjct: 86 ----QHPNIVRLHDSIQE-ESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILES 140 Query: 155 VRHCHNCGVLHRDIKDENILI--DLNRGELKLIDFGSGALLKDT-VYTDFDGTRVYSPPE 211 + +CH+ G++HR++K EN+L+ +KL DFG + D+ + F GT Y PE Sbjct: 141 IAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLSPE 200 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPF-EHDEEIIRGQVFFR---------QRVSS 261 ++ Y + +W+ G++LY ++ G PF + D+ + Q+ V+ Sbjct: 201 VLKKDPY-SKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTVTP 259 Query: 262 ECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 E + LI L + P R T ++ PW+ Sbjct: 260 EAKSLIDSMLTVNPKKRITADQALKVPWI 288 >3KK8-A nrPDB Length = 284 Score = 80.9 bits (198), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 69/272 (25%), Positives = 121/272 (44%), Gaps = 25/272 (9%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRIS--DWGELPNGTRVPMEVV 91 Y V LG G F V + + L A K + ++S D+ +L R+ ++ Sbjct: 4 FSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSARDFQKLEREARICRKL- 62 Query: 92 LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQV 151 ++RL D + +SF ++ +LF+ I R E A Q+ Sbjct: 63 -------QHPNIVRLHDSIQE-ESFHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQI 114 Query: 152 LEAVRHCHNCGVLHRDIKDENILI--DLNRGELKLIDFGSGALLKDT-VYTDFDGTRVYS 208 LE++ +CH+ G++HR++K EN+L+ +KL DFG + D+ + F GT Y Sbjct: 115 LESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYL 174 Query: 209 PPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF-EHDEEIIRGQVFFR---------QR 258 PE ++ Y + +W+ G++LY ++ G PF + D+ + Q+ Sbjct: 175 SPEVLKKDPY-SKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDT 233 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 V+ E + LI L + P R T ++ PW+ Sbjct: 234 VTPEAKSLIDSMLTVNPKKRITADQALKVPWI 265 >3M42-A nrPDB Length = 299 Score = 80.9 bits (198), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 66/217 (30%), Positives = 96/217 (44%), Gaps = 43/217 (19%) Query: 103 VIRLLDWFER---PDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLEAVRH 157 ++R++D +E +LI+ +LF I +RG A E A + EA+++ Sbjct: 73 IVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQY 132 Query: 158 CHNCGVLHRDIKDENILIDLNRGE--LKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRY 215 H+ + HRD+K EN+L R LKL DFG K+T +D Sbjct: 133 LHSINIAHRDVKPENLLYTSKRPNAILKLTDFG---FAKETTGEKYD------------- 176 Query: 216 HRYHGRSAAVWSLGILLYDMVCGDIPFEHDE----------EIIRGQVFFRQ----RVSS 261 +S +WSLG+++Y ++CG PF + I GQ F VS Sbjct: 177 -----KSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSE 231 Query: 262 ECQHLIRWCLALRPSDRPTFEEIQNHPW-MQDVLLPQ 297 E + LIR L P+ R T E NHPW MQ +PQ Sbjct: 232 EVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 268 >5D7A-A nrPDB Length = 308 Score = 80.5 bits (197), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 80/277 (28%), Positives = 120/277 (43%), Gaps = 32/277 (11%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 +++ L+G+G +G VY G V AIK + D D E + E+ +LKK S Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVM--DVTGDEEE-----EIKQEINMLKKYS 71 Query: 98 -----SGFSGVIRLLDWFERPDSFVLILE--RPEPVQDLFDFITERGALQEELARSFFWQ 150 + + G + D L++E V DL T+ L+EE + Sbjct: 72 HHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKN-TKGNTLKEEWIAYICRE 130 Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYS 208 +L + H H V+HRDIK +N+L+ N E+KL+DFG A L TV F GT + Sbjct: 131 ILRGLSHLHQHKVIHRDIKGQNVLLTEN-AEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 189 Query: 209 PPEWIRYHR----YHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF--------- 255 PE I + + +WSLGI +M G P D +R Sbjct: 190 APEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPL-CDMHPMRALFLIPRNPAPRLK 248 Query: 256 RQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 ++ S + Q I CL S RP E++ HP+++D Sbjct: 249 SKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRD 285 >4RA4-A nrPDB Length = 355 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 70/274 (25%), Positives = 120/274 (43%), Gaps = 25/274 (9%) Query: 13 RAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKD 72 R P N+L KL + + +LG G FG V R AIK ++KD Sbjct: 7 RKQPSNNLDRVKL----------TDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKD 56 Query: 73 RISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDF 132 + ++ + LL K + +L F+ D ++E DL Sbjct: 57 VVIQDDDVECTMVEKRVLALLDKPPF----LTQLHSCFQTVDRLYFVMEYVNG-GDLMYH 111 Query: 133 ITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA- 191 I + G +E A + ++ + H G+++RD+K +N+++D + G +K+ DFG Sbjct: 112 IQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLD-SEGHIKIADFGMCKE 170 Query: 192 -LLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE--- 247 ++ F GT Y PE I Y Y G+S W+ G+LLY+M+ G PF+ ++E Sbjct: 171 HMMDGVTTRTFCGTPDYIAPEIIAYQPY-GKSVDWWAYGVLLYEMLAGQPPFDGEDEDEL 229 Query: 248 ---IIRGQVFFRQRVSSECQHLIRWCLALRPSDR 278 I+ V + + +S E + + + P+ R Sbjct: 230 FQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKR 263 >4TNB-A nrPDB Length = 590 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 79/281 (28%), Positives = 127/281 (45%), Gaps = 41/281 (14%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM-EVVLLKK 95 QY+V LG GGFG V + + A K +EK RI G + + E +L+K Sbjct: 188 QYRV---LGKGGFGEVCACQVRATGKMYACKRLEKKRIKKR----KGESMALNEKQILEK 240 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLE 153 V+S F V+ L +E D+ L+L DL I G +EE A + ++L Sbjct: 241 VNSQF--VVNLAYAYETKDALCLVLTIMNG-GDLKFHIYNMGNPGFEEERALFYAAEILC 297 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG------SGALLKDTVYTDFDGTRVY 207 + H+ ++RD+K ENIL+D + G +++ D G G L++ V GT Y Sbjct: 298 GLEDLHHENTVYRDLKPENILLD-DYGHIRISDLGLAVKIPEGDLIRGRV-----GTVGY 351 Query: 208 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF----------EHDEEIIRGQVFFRQ 257 PE + RY G S W LG L+Y+M+ G PF E D ++ + + Sbjct: 352 MAPEVLNNQRY-GLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSH 410 Query: 258 RVSSECQHLIRWCLALRPSDRPTFE-----EIQNHPWMQDV 293 + S E + + + L R + E++ HP+ +++ Sbjct: 411 KFSEEAKSICKMLLTKDAKQRLGCQEEEAAEVKRHPFFRNM 451 >2BPM-A nrPDB Length = 309 Score = 79.0 bits (193), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 69/242 (28%), Positives = 111/242 (45%), Gaps = 15/242 (6%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 +G G +G VY VA+K + D ++ G R E+ LLK+++ + Sbjct: 15 IGEGTYGVVYKARNKLTGEVVALKKIRLDTETE-GVPSTAIR---EISLLKELNH--PNI 68 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLEAVRHCHNC 161 ++LLD + L+ E QDL F+ + L +S+ +Q+L+ + CH+ Sbjct: 69 VKLLDVIHTENKLYLVFEFLH--QDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSH 126 Query: 162 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEWIRYHRYH 219 VLHRD+K +N+LI+ G +KL DFG V YT T Y PE + +Y+ Sbjct: 127 RVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 185 Query: 220 GRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRP 279 + +WSLG + +MV F D EI Q+F R ++ + P +P Sbjct: 186 STAVDIWSLGCIFAEMVTRRALFPGDSEI--DQLFRIFRTLGTPDEVVWPGVTSMPDYKP 243 Query: 280 TF 281 +F Sbjct: 244 SF 245 >4AGU-A nrPDB Length = 311 Score = 79.0 bits (193), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 75/310 (24%), Positives = 131/310 (42%), Gaps = 50/310 (16%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM-EVVL 92 +E ++G + G G +G V+ VAIK + + + P ++ + E+ + Sbjct: 2 MEKYEKIGKI-GEGSYGVVFKCRNRDTGQIVAIK-----KFLESEDDPVIKKIALREIRM 55 Query: 93 LKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 LK++ ++ LL+ F R L+ E + L + + + E L +S WQ L Sbjct: 56 LKQLKH--PNLVNLLEVFRRKRRLHLVFEYCDHTV-LHELDRYQRGVPEHLVKSITWQTL 112 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPP 210 +AV CH +HRD+K ENILI +KL DFG LL Y D TR Y P Sbjct: 113 QAVNFCHKHNCIHRDVKPENILIT-KHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSP 171 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVC---------------------GDIPFEHDEEII 249 E + +G VW++G + +++ GD+ H + Sbjct: 172 ELLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFS 231 Query: 250 RGQVFFRQR----------------VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 Q F + +S L++ CL + P++R T E++ +HP+ +++ Sbjct: 232 TNQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENI 291 Query: 294 LLPQETAEIH 303 ++ A+ H Sbjct: 292 REIEDLAKEH 301 >4AU8-A nrPDB Length = 296 Score = 79.0 bits (193), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 63/209 (30%), Positives = 100/209 (47%), Gaps = 12/209 (5%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +Y+ +G G +G+V+ + VA+K V D D G + R E+ LLK++ Sbjct: 7 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDD-DDEGVPSSALR---EICLLKEL 62 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSFFWQVLEAV 155 ++RL D L+ E + QDL + G L E+ +SF +Q+L+ + Sbjct: 63 KH--KNIVRLHDVLHSDKKLTLVFEFCD--QDLKKYFDSCNGDLDPEIVKSFLFQLLKGL 118 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEWI 213 CH+ VLHRD+K +N+LI+ N GELKL DFG V Y+ T Y PP+ + Sbjct: 119 GFCHSRNVLHRDLKPQNLLINRN-GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVL 177 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPF 242 + + S +WS G + ++ P Sbjct: 178 FGAKLYSTSIDMWSAGCIFAELANAGRPL 206 >3TXO-A nrPDB Length = 353 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 63/245 (25%), Positives = 116/245 (47%), Gaps = 17/245 (6%) Query: 43 LLGSGGFGSVY-SGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS 101 +LG G FG V + ++ + +L A+K ++KD I + M + ++ Sbjct: 30 VLGKGSFGKVMLARVKETGDL-YAVKVLKKDVILQ----DDDVECTMTEKRILSLARNHP 84 Query: 102 GVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNC 161 + +L F+ PD ++E DL I + E AR + +++ A+ H+ Sbjct: 85 FLTQLFCCFQTPDRLFFVMEFVNG-GDLMFHIQKSRRFDEARARFYAAEIISALMFLHDK 143 Query: 162 GVLHRDIKDENILIDLNRGELKLIDFG--SGALLKDTVYTDFDGTRVYSPPEWIRYHRYH 219 G+++RD+K +N+L+D + G KL DFG + F GT Y PE ++ Y Sbjct: 144 GIIYRDLKLDNVLLD-HEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLY- 201 Query: 220 GRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRVSSECQHLIRWCLAL 273 G + W++G+LLY+M+CG PFE + E I+ +V + + + +++ + Sbjct: 202 GPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTK 261 Query: 274 RPSDR 278 P+ R Sbjct: 262 NPTMR 266 >2XNP-A nrPDB Length = 279 Score = 79.0 bits (193), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 80/274 (29%), Positives = 127/274 (46%), Gaps = 31/274 (11%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM--EVVLLKK 95 Y+V +G+G +G R SD + K + D+G + + + EV LL++ Sbjct: 8 YEVLYTIGTGSYGRCQKIRRKSDGKILVWKEL------DYGSMTEAEKQMLVSEVNLLRE 61 Query: 96 VSSGFSGVIRLLD-WFERPDSFVLILERPEPVQDLFDFIT----ERGALQEELARSFFWQ 150 + ++R D +R ++ + I+ DL IT ER L EE Q Sbjct: 62 LKH--PNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQ 119 Query: 151 VLEAVRHCHNCG-----VLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTD-FDG 203 + A++ CH VLHRD+K N+ +D + +KL DFG +L DT + F G Sbjct: 120 LTLALKECHRRSDGGHTVLHRDLKPANVFLD-GKQNVKLGDFGLARILNHDTSFAKTFVG 178 Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE-HDEEIIRGQVF---FRQ-- 257 T Y PE + Y+ +S +WSLG LLY++ PF ++ + G++ FR+ Sbjct: 179 TPYYMSPEQMNRMSYNEKS-DIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIP 237 Query: 258 -RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 R S E +I L L+ RP+ EEI +P + Sbjct: 238 YRYSDELNEIITRMLNLKDYHRPSVEEILENPLI 271 >5O0Y-A nrPDB Length = 579 Score = 78.6 bits (192), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 79/318 (24%), Positives = 139/318 (43%), Gaps = 33/318 (10%) Query: 3 LSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNL 62 L ++ + +L +H + K+ L +Y + LLG GGF VY +++ Sbjct: 251 LERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQR 310 Query: 63 PVAIK-HVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFE-RPDSFVLIL 120 VA+K H D + E + K++ +++L D+F DSF +L Sbjct: 311 YVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELD--HPRIVKLYDYFSLDTDSFCTVL 368 Query: 121 ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCG--VLHRDIKDENILI--D 176 E E DL ++ + + E+ ARS Q++ A+++ + ++H D+K NIL+ Sbjct: 369 EYCEG-NDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNG 427 Query: 177 LNRGELKLIDFGSGALLKDTVYTDFDGTRV---------YSPPEWIRYHRYH---GRSAA 224 GE+K+ DFG ++ D Y DG + Y PPE + Sbjct: 428 TACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVD 487 Query: 225 VWSLGILLYDMVCGDIPFEHD---EEIIRGQVFFRQR---------VSSECQHLIRWCLA 272 VWS+G++ Y + G PF H+ ++I++ + V+ E + IR CLA Sbjct: 488 VWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLA 547 Query: 273 LRPSDRPTFEEIQNHPWM 290 R DR +++ P++ Sbjct: 548 YRKEDRIDVQQLACDPYL 565 >3NIZ-A nrPDB Length = 311 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 63/208 (30%), Positives = 99/208 (47%), Gaps = 13/208 (6%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 L +YQ +G G +G VY + S VA+K + D D G R E+ LL Sbjct: 19 LMEKYQKLEKVGEGTYGVVYKA-KDSQGRIVALKRIRLD-AEDEGIPSTAIR---EISLL 73 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSFFWQVL 152 K++ ++ L+D L+ E E +DL + E + LQ+ + + +Q+L Sbjct: 74 KELHH--PNIVSLIDVIHSERCLTLVFEFME--KDLKKVLDENKTGLQDSQIKIYLYQLL 129 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPP 210 V HCH +LHRD+K +N+LI+ + G LKL DFG V YT T Y P Sbjct: 130 RGVAHCHQHRILHRDLKPQNLLIN-SDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAP 188 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCG 238 + + + + S +WS+G + +M+ G Sbjct: 189 DVLMGSKKYSTSVDIWSIGCIFAEMITG 216 >6FD3-A nrPDB Length = 300 Score = 77.4 bits (189), Expect = 8e-15, Method: Compositional matrix adjust. Identities = 64/260 (24%), Positives = 127/260 (48%), Gaps = 25/260 (9%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 +G G G+VY+ + ++ VAIK + + + P + E++++++ + + Sbjct: 30 IGQGASGTVYTALDIATGQEVAIKQM------NLQQQPKKELIINEILVMRENKN--PNI 81 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGV 163 + LD + D +++E L D +TE + ++A + + L+A+ H+ V Sbjct: 82 VNYLDSYLVGDELWVVMEYLAG-GSLTDVVTETCMDEGQIA-AVCRECLQALDFLHSNQV 139 Query: 164 LHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYTDFDGTRVYSPPEWIRYHRYHGR 221 +HRDIK +NIL+ ++ G +KL DFG A + + + + GT + PE + Y G Sbjct: 140 IHRDIKSDNILLGMD-GSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY-GP 197 Query: 222 SAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR----------QRVSSECQHLIRWCL 271 +WSLGI+ +MV G+ P+ +E +R +R+S+ + + CL Sbjct: 198 KVDIWSLGIMAIEMVEGEPPY-LNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCL 256 Query: 272 ALRPSDRPTFEEIQNHPWMQ 291 + R + +E+ HP+++ Sbjct: 257 EMDVDRRGSAKELLQHPFLK 276 >6O6Q-A nrPDB Length = 335 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 57/213 (26%), Positives = 100/213 (46%), Gaps = 17/213 (7%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 + Y++ LG G + V+ GI + V IK ++ + ++ E+ +LK Sbjct: 40 QENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKPVK---------RKKIKREISILK 90 Query: 95 KVSSGFSGVIRLLDWFERPDSFV--LILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 + G +I +LD P S LI E + DF + + R + +++L Sbjct: 91 NLVDG-PNIIAMLDVVREPQSKTPGLIFEHINNI----DFRSLYPTFTDYDIRFYMYELL 145 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRVYSPPE 211 +A+ + H+ G++HRD+K N++ID ++ L+LID+G T Y +R + PE Sbjct: 146 KALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPE 205 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH 244 + +R + S +WS G +L MV PF H Sbjct: 206 LLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFH 238 >1KOA-A nrPDB Length = 491 Score = 76.6 bits (187), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 76/281 (27%), Positives = 120/281 (42%), Gaps = 27/281 (9%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 Y + LG+G FG V+ + A K V SD R ++ + + + Sbjct: 52 HYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESD----KETVRKEIQTMSVLRH 107 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156 + ++ L D FE + V+I E + E + E+ A + QV + + Sbjct: 108 PT----LVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLC 163 Query: 157 HCHNCGVLHRDIKDENILIDLNR-GELKLIDFGSGALL--KDTVYTDFDGTRVYSPPEWI 213 H H +H D+K ENI+ R ELKLIDFG A L K +V GT ++ PE + Sbjct: 164 HMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVT-TGTAEFAAPE-V 221 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHDEEIIRG----------QVFFRQRVSS 261 + G +WS+G+L Y ++ G PF E+D+E +R F +S Sbjct: 222 AEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAF--SGISE 279 Query: 262 ECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEI 302 + + IR L P+ R T + HPW+ P ++I Sbjct: 280 DGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQI 320 >3UTO-A nrPDB Length = 573 Score = 76.3 bits (186), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 76/281 (27%), Positives = 120/281 (42%), Gaps = 27/281 (9%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 Y + LG+G FG V+ + A K V SD R ++ + + + Sbjct: 158 HYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESD----KETVRKEIQTMSVLRH 213 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156 + ++ L D FE + V+I E + E + E+ A + QV + + Sbjct: 214 PT----LVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLC 269 Query: 157 HCHNCGVLHRDIKDENILIDLNR-GELKLIDFGSGALL--KDTVYTDFDGTRVYSPPEWI 213 H H +H D+K ENI+ R ELKLIDFG A L K +V GT ++ PE + Sbjct: 270 HMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVT-TGTAEFAAPE-V 327 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHDEEIIRG----------QVFFRQRVSS 261 + G +WS+G+L Y ++ G PF E+D+E +R F +S Sbjct: 328 AEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAF--SGISE 385 Query: 262 ECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEI 302 + + IR L P+ R T + HPW+ P ++I Sbjct: 386 DGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQI 426 >2F9G-A nrPDB Length = 353 Score = 76.3 bits (186), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 79/323 (24%), Positives = 133/323 (41%), Gaps = 66/323 (20%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 + S +Q+ LLG G +G V S VAIK +E + + R E+ +L Sbjct: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP-----FDKPLFALRTLREIKIL 63 Query: 94 KKVSSGFSGVIRLLDWFERPDSF-----VLILERPEPVQDLFDFITERGALQEELARSFF 148 K +I + + +RPDSF V I++ E +Q + L ++ + F Sbjct: 64 KHFKH--ENIITIFN-IQRPDSFENFNEVYIIQ--ELMQTDLHRVISTQMLSDDHIQYFI 118 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV----------- 197 +Q L AV+ H V+HRD+K N+LI+ N +LK+ DFG ++ ++ Sbjct: 119 YQTLRAVKVLHGSNVIHRDLKPSNLLINSN-CDLKVCDFGLARIIDESAADNSEPTGQQS 177 Query: 198 -YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYD------------------MVCG 238 T++ TR Y PE + + R+ VWS G +L + ++ G Sbjct: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 Query: 239 DIPFEHDE------EIIRGQVFFRQ--------------RVSSECQHLIRWCLALRPSDR 278 I H + E R + + + RV+ + L++ L P+ R Sbjct: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR 297 Query: 279 PTFEEIQNHPWMQDVLLPQETAE 301 T +E HP++Q P + E Sbjct: 298 ITAKEALEHPYLQTYHDPNDEPE 320 >5G6V-A nrPDB Length = 324 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 62/200 (31%), Positives = 99/200 (49%), Gaps = 17/200 (8%) Query: 44 LGSGGFGSVYSG-IRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 LG G + +VY G +++DNL VA+K + + + G R EV LLK + + Sbjct: 10 LGEGTYATVYKGKSKLTDNL-VALKEIRLEH--EEGAPCTAIR---EVSLLKDLKH--AN 61 Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQVLEAVRHCHNC 161 ++ L D S L+ E + +DL ++ + G + + F +Q+L + +CH Sbjct: 62 IVTLHDIIHTEKSLTLVFEYLD--KDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQ 119 Query: 162 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---YSPPEWIRYHRY 218 VLHRD+K +N+LI+ RGELKL DFG A K +D V Y PP+ + Sbjct: 120 KVLHRDLKPQNLLIN-ERGELKLADFGL-ARAKSIPTKTYDNEVVTLWYRPPDILLGSTD 177 Query: 219 HGRSAAVWSLGILLYDMVCG 238 + +W +G + Y+M G Sbjct: 178 YSTQIDMWGVGCIFYEMATG 197 >2I0E-A nrPDB Length = 353 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 64/251 (25%), Positives = 116/251 (46%), Gaps = 29/251 (11%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 +LG G FG V R + A+K ++KD + ++ E +++K G Sbjct: 27 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDV--------ECTMVEKRVLALPG 78 Query: 103 ----VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHC 158 + +L F+ D ++E DL I + G +E A + ++ + Sbjct: 79 KPPFLTQLHSCFQTMDRLYFVMEYVNG-GDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 137 Query: 159 HNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY-----TDFDGTRVYSPPEWI 213 + G+++RD+K +N+++D + G +K+ DFG + K+ ++ F GT Y PE I Sbjct: 138 QSKGIIYRDLKLDNVMLD-SEGHIKIADFG---MCKENIWDGVTTKTFCGTPDYIAPEII 193 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRVSSECQHLI 267 Y Y G+S W+ G+LLY+M+ G PFE ++E I+ V + + +S E + Sbjct: 194 AYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 252 Query: 268 RWCLALRPSDR 278 + + P R Sbjct: 253 KGLMTKHPGKR 263 >3PFQ-A nrPDB Length = 674 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 64/251 (25%), Positives = 116/251 (46%), Gaps = 29/251 (11%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 +LG G FG V R + A+K ++KD + ++ E +++K G Sbjct: 348 VLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDV--------ECTMVEKRVLALPG 399 Query: 103 ----VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHC 158 + +L F+ D ++E DL I + G +E A + ++ + Sbjct: 400 KPPFLTQLHSCFQTMDRLYFVMEYVNG-GDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFL 458 Query: 159 HNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY-----TDFDGTRVYSPPEWI 213 + G+++RD+K +N+++D + G +K+ DFG + K+ ++ F GT Y PE I Sbjct: 459 QSKGIIYRDLKLDNVMLD-SEGHIKIADFG---MCKENIWDGVTTKTFCGTPDYIAPEII 514 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRVSSECQHLI 267 Y Y G+S W+ G+LLY+M+ G PFE ++E I+ V + + +S E + Sbjct: 515 AYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAIC 573 Query: 268 RWCLALRPSDR 278 + + P R Sbjct: 574 KGLMTKHPGKR 584 >3PVW-A nrPDB Length = 695 Score = 75.9 bits (185), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 99/209 (47%), Gaps = 8/209 (3%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM-EVVLLK 94 + + V ++G GGFG VY + A+K ++K RI ++ G + + E ++L Sbjct: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI----KMKQGETLALNERIMLS 244 Query: 95 KVSSGFSGVIRLLDW-FERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 VS+G I + + F PD IL+ DL +++ G E R + +++ Sbjct: 245 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNG-GDLHYHLSQHGVFSEADMRFYAAEIIL 303 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWI 213 + H HN V++RD+K NIL+D G +++ D G GT Y PE + Sbjct: 304 GLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVL 362 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPF 242 + + SA +SLG +L+ ++ G PF Sbjct: 363 QKGVAYDSSADWFSLGCMLFKLLRGHSPF 391 >5UUU-A nrPDB Length = 547 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 58/209 (27%), Positives = 99/209 (47%), Gaps = 8/209 (3%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM-EVVLLK 94 + + V ++G GGFG VY + A+K ++K RI ++ G + + E ++L Sbjct: 198 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRI----KMKQGETLALNERIMLS 253 Query: 95 KVSSGFSGVIRLLDW-FERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 VS+G I + + F PD IL+ DL +++ G E R + +++ Sbjct: 254 LVSTGDCPFIVCMSYAFHTPDKLSFILDLMNG-GDLHYHLSQHGVFSEADMRFYAAEIIL 312 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWI 213 + H HN V++RD+K NIL+D G +++ D G GT Y PE + Sbjct: 313 GLEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVL 371 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPF 242 + + SA +SLG +L+ ++ G PF Sbjct: 372 QKGVAYDSSADWFSLGCMLFKLLRGHSPF 400 >4BGQ-A nrPDB Length = 304 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 65/228 (28%), Positives = 114/228 (50%), Gaps = 16/228 (7%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +++++ ++G G +G V + VAIK K + S+ E T + E+ +L+ Sbjct: 12 NKFEILGVVGEGAYGVVLKCRHKETHEIVAIK---KFKDSEENEEVKETTL-RELKMLRT 67 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER-GALQEELARSFFWQVLEA 154 + ++ L + F R L+ E E +++ + + E + E +S+ +Q+++A Sbjct: 68 LKQ--ENIVELKEAFRRRGKLYLVFEYVE--KNMLELLEEMPNGVPPEKVKSYIYQLIKA 123 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD---GTRVYSPPE 211 + CH ++HRDIK EN+LI N LKL DFG L + ++D TR Y PE Sbjct: 124 IHWCHKNDIVHRDIKPENLLISHN-DVLKLCDFGFARNLSEGNNANYDEEVATRWYRSPE 182 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRV 259 + Y G+S +WS+G +L ++ G F + EI Q+F Q+V Sbjct: 183 LLLGAPY-GKSVDMWSVGCILGELSDGQPLFPGESEI--DQLFTIQKV 227 >4FR4-A nrPDB Length = 384 Score = 75.5 bits (184), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 67/269 (24%), Positives = 126/269 (46%), Gaps = 20/269 (7%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 +++ +G G FG V + A+K++ K + + E+ N V E+ +++ + Sbjct: 17 FEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRN---VFKELQIMQGLE 73 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 F ++ L F+ + ++++ DL + + +EE + F +++ A+ + Sbjct: 74 HPF--LVNLWYSFQDEEDMFMVVDLLLG-GDLRYHLQQNVHFKEETVKLFICELVMALDY 130 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL-KDTVYTDFDGTRVYSPPEWIRYH 216 N ++HRD+K +NIL+D G + + DF A+L ++T T GT+ Y PE Sbjct: 131 LQNQRIIHRDMKPDNILLD-EHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFSSR 189 Query: 217 RYHGRSAAV--WSLGILLYDMVCGDIPFE-----HDEEIIR----GQVFFRQRVSSECQH 265 + G S AV WSLG+ Y+++ G P+ +EI+ V + S E Sbjct: 190 KGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEMVS 249 Query: 266 LIRWCLALRPSDR-PTFEEIQNHPWMQDV 293 L++ L P R ++QN P+M D+ Sbjct: 250 LLKKLLEPNPDQRFSQLSDVQNFPYMNDI 278 >3HDN-A nrPDB Length = 373 Score = 75.1 bits (183), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 71/275 (25%), Positives = 123/275 (44%), Gaps = 19/275 (6%) Query: 25 LAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 84 L P S + ++G G FG V ++ + A+K ++K I E Sbjct: 27 LGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKE--EKH 84 Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELA 144 + VLLK V F ++ L F+ D +L+ + + ER L E A Sbjct: 85 IMSERNVLLKNVKHPF--LVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFL-EPRA 141 Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG--SGALLKDTVYTDFD 202 R + ++ A+ + H+ +++RD+K ENIL+D ++G + L DFG + ++ + F Sbjct: 142 RFYAAEIASALGYLHSLNIVYRDLKPENILLD-SQGHIVLTDFGLCKENIEHNSTTSTFC 200 Query: 203 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF------EHDEEIIRGQVFFR 256 GT Y PE + Y R+ W LG +LY+M+ G PF E + I+ + + Sbjct: 201 GTPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLK 259 Query: 257 QRVSSECQHLIRWCL----ALRPSDRPTFEEIQNH 287 +++ +HL+ L R + F EI++H Sbjct: 260 PNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSH 294 >4MYG-A nrPDB Length = 372 Score = 75.1 bits (183), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 63/206 (30%), Positives = 102/206 (49%), Gaps = 18/206 (8%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 +GSG +GSV S I VAIK + + S+ R E++LLK + V Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIF----AKRAYRELLLLKHMQH--ENV 104 Query: 104 IRLLDWFERPDS------FVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 I LLD F S F L++ P DL + EE + +Q+L+ +++ Sbjct: 105 IGLLDVFTPASSLRNFYDFYLVM--PFMQTDLQKIMGME--FSEEKIQYLVYQMLKGLKY 160 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHR 217 H+ GV+HRD+K N+ ++ + ELK++DFG A D T + TR Y PE I Sbjct: 161 IHSAGVVHRDLKPGNLAVNED-CELKILDFGL-ARHADAEMTGYVVTRWYRAPEVILSWM 218 Query: 218 YHGRSAAVWSLGILLYDMVCGDIPFE 243 ++ ++ +WS+G ++ +M+ G F+ Sbjct: 219 HYNQTVDIWSVGCIMAEMLTGKTLFK 244 >5LOH-A nrPDB Length = 341 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 72/281 (25%), Positives = 130/281 (46%), Gaps = 29/281 (10%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEK-DRISDWGELPNGTRVPME 89 K P ++ + + G FG VY G + A+K V+K D I+ + + + + Sbjct: 31 KPPSIEEFSIVKPISRGAFGKVYLGQKGGK--LYAVKVVKKADMINK--NMTHQVQAERD 86 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 + L K S F ++ L + ++ L++E D+ + G EE+A + Sbjct: 87 ALALSK--SPF--IVHLYYSLQSANNVYLVMEY-LIGGDVKSLLHIYGYFDEEMAVKYIS 141 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL-------LKDTVYT-DF 201 +V A+ + H G++HRD+K +N+LI N G +KL DFG + + D + T F Sbjct: 142 EVALALDYLHRHGIIHRDLKPDNMLIS-NEGHIKLTDFGLSKVTLNRDINMMDILTTRTF 200 Query: 202 DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFF 255 GT Y PE + R HG + W+LG+ L++ + G PF + + I++ + + Sbjct: 201 CGTPDYLAPELL-LGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPW 259 Query: 256 ---RQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 +++S Q + L + + R +E++ HP DV Sbjct: 260 PEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDV 300 >3OHT-A nrPDB Length = 389 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 59/230 (25%), Positives = 106/230 (46%), Gaps = 25/230 (10%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +YQ +GSG +GSV S V L +A+K + + + + + R E+ LLK + Sbjct: 52 RYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRP----FQSIIHAKRTYRELRLLKHM 107 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA----------LQEELARS 146 VI LLD F S E D++ GA L ++ + Sbjct: 108 KH--ENVIGLLDVFTPATSL-------EEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQF 158 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV 206 +Q+L +++ H+ ++HRD+K N+ ++ + ELK++DFG D + T + TR Sbjct: 159 LIYQILRGLKYIHSADIIHRDLKPSNLAVNED-CELKILDFGLARHTDDEM-TGYVATRW 216 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR 256 Y PE + ++ + +WS+G ++ +++ G F + I + Q R Sbjct: 217 YRAPEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMR 266 >1V0B-A nrPDB Length = 288 Score = 75.1 bits (183), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 60/200 (30%), Positives = 101/200 (50%), Gaps = 17/200 (8%) Query: 44 LGSGGFGSVYSGIRVSDNL--PVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS 101 +G G +G VY + +N A+K + ++ D G +P+ T E+ +LK++ S Sbjct: 10 IGEGTYGVVY---KAQNNYGETFALKKIRLEK-EDEG-IPSTT--IREISILKELKH--S 60 Query: 102 GVIRLLDWFERPDSFVLILER-PEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHN 160 +++L D VL+ E + ++ L D G L+ A+SF Q+L + +CH+ Sbjct: 61 NIVKLYDVIHTKKRLVLVFEHLDQDLKKLLDVC--EGGLESVTAKSFLLQLLNGIAYCHD 118 Query: 161 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEWIRYHRY 218 VLHRD+K +N+LI+ GELK+ DFG V YT T Y P+ + + Sbjct: 119 RRVLHRDLKPQNLLIN-REGELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDVLMGSKK 177 Query: 219 HGRSAAVWSLGILLYDMVCG 238 + + +WS+G + +MV G Sbjct: 178 YSTTIDIWSVGCIFAEMVNG 197 >4QMW-A nrPDB Length = 310 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 71/259 (27%), Positives = 113/259 (43%), Gaps = 26/259 (10%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 +G G FG V+ GI VAIK ++ + D + E+ +L + S + V Sbjct: 37 IGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAED-----EIEDIQQEITVLSQCDSPY--V 89 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGV 163 + + + +I+E L D + E G L E + ++L+ + + H+ Sbjct: 90 TKYYGSYLKDTKLWIIMEYLGGGSAL-DLL-EPGPLDETQIATILREILKGLDYLHSEKK 147 Query: 164 LHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY--TDFDGTRVYSPPEWIRYHRYHGR 221 +HRDIK N+L+ GE+KL DFG L DT F GT + PE I+ Y + Sbjct: 148 IHRDIKAANVLLS-EHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSK 206 Query: 222 SAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF----------RQRVSSECQHLIRWCL 271 A +WSLGI ++ G+ P E+ +V F S + + CL Sbjct: 207 -ADIWSLGITAIELARGEPPH---SELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACL 262 Query: 272 ALRPSDRPTFEEIQNHPWM 290 PS RPT +E+ H ++ Sbjct: 263 NKEPSFRPTAKELLKHKFI 281 >5XVU-A nrPDB Length = 332 Score = 74.7 bits (182), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 67/275 (24%), Positives = 128/275 (46%), Gaps = 27/275 (9%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 ++Y++ +G G + V++G N P AIK ++ + ++ E+ +L+ Sbjct: 31 NRYEIMKKIGRGKYSEVFNGYDTECNRPCAIKVLKPVK---------KKKIKREIKILQN 81 Query: 96 VSSGFSGVIRLLDWFERPDSFV--LILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 ++ G +I+LLD + P + LI E + DF T ++ R + +Q+L+ Sbjct: 82 LNGG-PNIIKLLDIVKDPVTKTPSLIFEYINNI----DFKTLYPKFTDKDIRYYIYQILK 136 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRVYSPPEW 212 A+ +CH+ G++HRD+K NI+ID +++LI +G Y +R Y PE Sbjct: 137 ALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRVASRYYKGPEL 196 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPF-----EHDEEIIRGQVFFRQRVSSECQHLI 267 + + + S +WSLG +L M+ PF +D+ + +V + + + +L Sbjct: 197 LIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHA---YLK 253 Query: 268 RWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEI 302 ++ + L+P E + PW L Q +I Sbjct: 254 KYNIKLKPHYLNILGEYERKPWSH--FLTQSNIDI 286 >3DB8-A nrPDB Length = 317 Score = 74.3 bits (181), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 71/261 (27%), Positives = 115/261 (44%), Gaps = 24/261 (9%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +Y G LG GGF Y + A K V K + + ++ E+ + K Sbjct: 42 KRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQ---KEKMSTEIAIHKS 98 Query: 96 VSS----GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQV 151 + + GF G +FE D FV ++ + L + R A+ E AR F Q Sbjct: 99 LDNPHVVGFHG------FFED-DDFVYVVLEICRRRSLLELHKRRKAVTEPEARYFMRQT 151 Query: 152 LEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSP 209 ++ V++ HN V+HRD+K N+ ++ + ++K+ DFG ++ D GT Y Sbjct: 152 IQGVQYLHNNRVIHRDLKLGNLFLN-DDMDVKIGDFGLATKIEFDGERKKDLCGTPNYIA 210 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD---EEIIR---GQVFFRQRVSSEC 263 PE + + H +WSLG +LY ++ G PFE E IR + + ++ Sbjct: 211 PEVL-CKKGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHINPVA 269 Query: 264 QHLIRWCLALRPSDRPTFEEI 284 LIR L P+ RP+ E+ Sbjct: 270 SALIRRMLHADPTLRPSVAEL 290 >3GC0-A nrPDB Length = 329 Score = 74.3 bits (181), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 62/211 (29%), Positives = 96/211 (45%), Gaps = 14/211 (6%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 LG G +G VY I N VAIK + R+ E GT + EV LLK++ + Sbjct: 42 LGEGTYGEVYKAIDTVTNETVAIKRI---RLEHEEEGVPGTAI-REVSLLKELQH--RNI 95 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGV 163 I L LI E E DL ++ + + + +SF +Q++ V CH+ Sbjct: 96 IELKSVIHHNHRLHLIFEYAE--NDLKKYMDKNPDVSMRVIKSFLYQLINGVNFCHSRRC 153 Query: 164 LHRDIKDENILIDLNRGE----LKLIDFGSGALLKDTV--YTDFDGTRVYSPPEWIRYHR 217 LHRD+K +N+L+ ++ LK+ DFG + +T T Y PPE + R Sbjct: 154 LHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRPPEILLGSR 213 Query: 218 YHGRSAAVWSLGILLYDMVCGDIPFEHDEEI 248 ++ S +WS+ + +M+ F D EI Sbjct: 214 HYSTSVDIWSIACIWAEMLMKTPLFPGDSEI 244 >5KCV-A nrPDB Length = 460 Score = 74.3 bits (181), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 68/257 (26%), Positives = 123/257 (47%), Gaps = 27/257 (10%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 ++++ LLG G FG V + A+K ++K+ I E+ + E +L+ Sbjct: 162 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH---TLTENRVLQN 218 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 F ++ F+ D ++E + F ER E+ AR + +++ A+ Sbjct: 219 SRHPFLTALKYS--FQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFYGAEIVSAL 275 Query: 156 RHCHN-CGVLHRDIKDENILIDLNRGELKLIDFG-------SGALLKDTVYTDFDGTRVY 207 + H+ V++RD+K EN+++D + G +K+ DFG GA +K F GT Y Sbjct: 276 DYLHSEKNVVYRDLKLENLMLDKD-GHIKITDFGLCKEGIKDGATMKT-----FCGTPEY 329 Query: 208 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF---EHD---EEIIRGQVFFRQRVSS 261 PE + + Y GR+ W LG+++Y+M+CG +PF +H+ E I+ ++ F + + Sbjct: 330 LAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGP 388 Query: 262 ECQHLIRWCLALRPSDR 278 E + L+ L P R Sbjct: 389 EAKSLLSGLLKKDPKQR 405 >3MV5-A nrPDB Length = 342 Score = 74.3 bits (181), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 68/257 (26%), Positives = 123/257 (47%), Gaps = 27/257 (10%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 ++++ LLG G FG V + A+K ++K+ I E+ + E +L+ Sbjct: 10 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH---TLTENRVLQN 66 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 F ++ F+ D ++E + F ER E+ AR + +++ A+ Sbjct: 67 SRHPFLTALKY--SFQTHDRLCFVMEYANGGELFFHLSRER-VFSEDRARFYGAEIVSAL 123 Query: 156 RHCHN-CGVLHRDIKDENILIDLNRGELKLIDFG-------SGALLKDTVYTDFDGTRVY 207 + H+ V++RD+K EN+++D + G +K+ DFG GA +K F GT Y Sbjct: 124 DYLHSEKNVVYRDLKLENLMLDKD-GHIKITDFGLCKEGIKDGATMKT-----FCGTPEY 177 Query: 208 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF---EHD---EEIIRGQVFFRQRVSS 261 PE + + Y GR+ W LG+++Y+M+CG +PF +H+ E I+ ++ F + + Sbjct: 178 LAPEVLEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGP 236 Query: 262 ECQHLIRWCLALRPSDR 278 E + L+ L P R Sbjct: 237 EAKSLLSGLLKKDPKQR 253 >2F57-A nrPDB Length = 317 Score = 73.9 bits (180), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 56/174 (32%), Positives = 90/174 (51%), Gaps = 14/174 (8%) Query: 129 LFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG 188 L D +T +E++A + VL A+ + HN GV+HRDIK ++IL+ + G +KL DFG Sbjct: 129 LTDIVTHTRMNEEQIA-TVCLSVLRALSYLHNQGVIHRDIKSDSILLT-SDGRIKLSDFG 186 Query: 189 SGALLKDTV--YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE 246 A + V GT + PE I Y G +WSLGI++ +M+ G+ P+ ++ Sbjct: 187 FCAQVSKEVPKRKSLVGTPYWMAPEVISRLPY-GTEVDIWSLGIMVIEMIDGEPPYFNEP 245 Query: 247 EI-----IRGQVFFR----QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 + IR + R +VSS + + L PS R T +E+ HP+++ Sbjct: 246 PLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLK 299 >6ED6-A nrPDB Length = 415 Score = 73.9 bits (180), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 58/208 (27%), Positives = 102/208 (49%), Gaps = 21/208 (10%) Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCG 162 V++L F+ D ++ ++ P DL + ++ + E+ A+ + +V+ A+ H+ G Sbjct: 150 VVQLFYAFQ-DDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWAKFYTAEVVLALDAIHSMG 207 Query: 163 VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD---GTRVYSPPEWIRYHR-- 217 ++HRD+K +N+L+D G LKL DFG+ + +T D GT Y PE ++ Sbjct: 208 LIHRDVKPDNMLLD-KHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGD 266 Query: 218 -YHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR----------VSSECQHL 266 ++GR WS+G+ LY+M+ GD PF D + + +S ++L Sbjct: 267 GFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNL 326 Query: 267 IRWCLALRPS--DRPTFEEIQNHPWMQD 292 I L R R EEI+ HP+ ++ Sbjct: 327 ICAFLTDREVRLGRNGVEEIRQHPFFKN 354 >3Q53-A nrPDB Length = 306 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 62/260 (23%), Positives = 124/260 (47%), Gaps = 25/260 (9%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 +G G G+VY+ + V+ VAI+ + + + P + E++++++ + + Sbjct: 29 IGQGASGTVYTAMDVATGQEVAIRQM------NLQQQPKKELIINEILVMRENKN--PNI 80 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGV 163 + LD + D +++E L D +TE + ++A + + L+A+ H+ V Sbjct: 81 VNYLDSYLVGDELWVVMEYLAG-GSLTDVVTETCMDEGQIA-AVCRECLQALEFLHSNQV 138 Query: 164 LHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYTDFDGTRVYSPPEWIRYHRYHGR 221 +HRDIK +NIL+ ++ G +KL DFG A + + + + GT + PE + Y G Sbjct: 139 IHRDIKSDNILLGMD-GSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAY-GP 196 Query: 222 SAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQH----------LIRWCL 271 +WSLGI+ +M+ G+ P+ +E +R + E Q+ + CL Sbjct: 197 KVDIWSLGIMAIEMIEGEPPY-LNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCL 255 Query: 272 ALRPSDRPTFEEIQNHPWMQ 291 + R + +E+ H +++ Sbjct: 256 EMDVEKRGSAKELIQHQFLK 275 >6CCF-A nrPDB Length = 290 Score = 73.6 bits (179), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 63/222 (28%), Positives = 102/222 (45%), Gaps = 23/222 (10%) Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERP--DSFVLILE--RPEPVQDLFDFITERGALQ 140 RV E+ +LKK+ V++L++ + P D+ L+ + R PV + + Sbjct: 74 RVYQEIAILKKLDH--VNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME----VPCDKPFS 127 Query: 141 EELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVY 198 EE AR + V+ + + H ++HRDIK N+L+ + G +K+ DFG + D Sbjct: 128 EEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLG-DDGHVKIADFGVSNQFEGNDAQL 186 Query: 199 TDFDGTRVYSPPEWI--RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIR 250 + GT + PE I + G++ VW+ G+ LY V G PF D +I Sbjct: 187 SSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILALHRKIKN 246 Query: 251 GQVFFRQ--RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 V F + +S E + LI L P R +I+ HPW+ Sbjct: 247 EPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWV 288 >6DTL-A nrPDB Length = 364 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 53/197 (26%), Positives = 97/197 (49%), Gaps = 11/197 (5%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 +G G +G V S + N VAIK + + + + R E+ LL+ + + Sbjct: 38 IGKGAYGIVCSAMNSETNESVAIKKIA----NAFDNKIDAKRTLREIKLLRHMDH--ENI 91 Query: 104 IRLLDWFERP--DSFVLILERPEPV-QDLFDFITERGALQEELARSFFWQVLEAVRHCHN 160 + + D P ++F + E + DL I AL EE + F +Q+L +++ H+ Sbjct: 92 VAIRDIIPPPLRNAFNDVYIAYELMDTDLHQIIRSNQALSEEHCQYFLYQILRGLKYIHS 151 Query: 161 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY-TDFDGTRVYSPPEWIRYHRYH 219 VLHRD+K N+L++ N +LK+ DFG + ++ + T++ TR Y PE + + Sbjct: 152 ANVLHRDLKPSNLLLNAN-CDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNSSDY 210 Query: 220 GRSAAVWSLGILLYDMV 236 + VWS+G + +++ Sbjct: 211 TAAIDVWSVGCIFMELM 227 >2HW6-A nrPDB Length = 307 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 79/311 (25%), Positives = 128/311 (41%), Gaps = 53/311 (17%) Query: 22 ATKLAPGKEKEPLESQYQV-GPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGEL 80 +T PGK E Y++ LLG G + V + + + A+K +EK Sbjct: 2 STDSLPGK----FEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGH----- 52 Query: 81 PNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQ 140 + +RV EV L + G ++ L+++FE F L+ E+ + + I ++ Sbjct: 53 -SRSRVFREVETLYQCQ-GNKNILELIEFFEDDTRFYLVFEKLQG-GSILAHIQKQKHFN 109 Query: 141 EELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDL--NRGELKLIDF--GSGALLKDT 196 E A V A+ H G+ HRD+K ENIL + +K+ DF GSG L ++ Sbjct: 110 EREASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNS 169 Query: 197 V-------YTDFDGTRVYSPPEWIRYH----RYHGRSAAVWSLGILLYDMVCGDIPF--- 242 T G+ Y PE + ++ + +WSLG++LY M+ G PF Sbjct: 170 CTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGH 229 Query: 243 ------------------EHDEEIIRGQVFFRQR----VSSECQHLIRWCLALRPSDRPT 280 + E I G+ F + +SSE + LI L R + Sbjct: 230 CGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLS 289 Query: 281 FEEIQNHPWMQ 291 ++ HPW+Q Sbjct: 290 AAQVLQHPWVQ 300 >1KOB-A nrPDB Length = 387 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 70/267 (26%), Positives = 114/267 (42%), Gaps = 23/267 (8%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 Y + LGSG FG V+ + + K + D + N E+ ++ ++ Sbjct: 53 YDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVKN------EISIMNQLH 106 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT-ERGALQEELARSFFWQVLEAVR 156 +I L D FE VLILE +LFD I E + E ++ Q E ++ Sbjct: 107 H--PKLINLHDAFEDKYEMVLILEFLSG-GELFDRIAAEDYKMSEAEVINYMRQACEGLK 163 Query: 157 HCHNCGVLHRDIKDENILIDLNRG-ELKLIDFGSGALLK-DTVYTDFDGTRVYSPPEWIR 214 H H ++H DIK ENI+ + + +K+IDFG L D + T ++ PE + Sbjct: 164 HMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEIVD 223 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR----------QRVSSECQ 264 G +W++G+L Y ++ G PF ++++ Q R VS E + Sbjct: 224 REPV-GFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDAFSSVSPEAK 282 Query: 265 HLIRWCLALRPSDRPTFEEIQNHPWMQ 291 I+ L P R T + HPW++ Sbjct: 283 DFIKNLLQKEPRKRLTVHDALEHPWLK 309 >3GC9-A nrPDB Length = 370 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 56/203 (27%), Positives = 100/203 (49%), Gaps = 13/203 (6%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 +GSG +GSV S VA+K + + + L + R E+ LLK + V Sbjct: 36 VGSGAYGSVCSAYDARLRQKVAVKKLSRP----FQSLIHARRTYRELRLLKHLK--HENV 89 Query: 104 IRLLDWFERPDSFVLILERPEPVQDL----FDFITERGALQEELARSFFWQVLEAVRHCH 159 I LLD F P + + V L + I + AL +E + +Q+L +++ H Sbjct: 90 IGLLDVFT-PATSIEDFSEVYLVTTLMGADLNNIVKSQALSDEHVQFLVYQLLRGLKYIH 148 Query: 160 NCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYH 219 + G++HRD+K N+ ++ + EL+++DFG A D T + TR Y PE + ++ Sbjct: 149 SAGIIHRDLKPSNVAVNED-SELRILDFGL-ARQADEEMTGYVATRWYRAPEIMLNWMHY 206 Query: 220 GRSAAVWSLGILLYDMVCGDIPF 242 ++ +WS+G ++ +++ G F Sbjct: 207 NQTVDIWSVGCIMAELLQGKALF 229 >1TKI-A nrPDB Length = 321 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 76/282 (26%), Positives = 119/282 (42%), Gaps = 40/282 (14%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVV 91 + L +Y + LG G FG V+ + S K V+ GT + V Sbjct: 1 KELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVK----------VKGT----DQV 46 Query: 92 LLKKVSSGFS-----GVIRLLDWFERPDSFVLILERPEPVQDLFDFI-TERGALQEELAR 145 L+KK S + ++ L + FE + V+I E + D+F+ I T L E Sbjct: 47 LVKKEISILNIARHRNILHLHESFESMEELVMIFEFISGL-DIFERINTSAFELNEREIV 105 Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE-LKLIDFGSGALLK--DTVYTDFD 202 S+ QV EA++ H+ + H DI+ ENI+ R +K+I+FG LK D F Sbjct: 106 SYVHQVCEALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFT 165 Query: 203 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHDEEIIRG--------- 251 Y+P + H + +WSLG L+Y ++ G PF E +++II Sbjct: 166 APEYYAPE--VHQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFD 223 Query: 252 -QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 + F + +S E + L R T E HPW++ Sbjct: 224 EEAF--KEISIEAMDFVDRLLVKERKSRMTASEALQHPWLKQ 263 >4BBM-A nrPDB Length = 331 Score = 73.2 bits (178), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 61/216 (28%), Positives = 104/216 (48%), Gaps = 12/216 (5%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM-EVVLLK 94 +Y+ L+G G +G V VAIK + SD ++ ++ M E+ LLK Sbjct: 25 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKFLE---SDDDKMVK--KIAMREIKLLK 79 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 ++ ++ LL+ ++ + L+ E + L D L ++ + + +Q++ Sbjct: 80 QLRH--ENLVNLLEVCKKKKRWYLVFEFVDHTI-LDDLELFPNGLDYQVVQKYLFQIING 136 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPEW 212 + CH+ ++HRDIK ENIL+ G +KL DFG L VY D TR Y PE Sbjct: 137 IGFCHSHNIIHRDIKPENILVS-QSGVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPEL 195 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEI 248 + +G++ VW++G L+ +M G+ F D +I Sbjct: 196 LVGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDI 231 >5AIR-A nrPDB Length = 430 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 73/277 (26%), Positives = 124/277 (44%), Gaps = 27/277 (9%) Query: 26 APGKEKE-PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 84 PG+ + P E Y ++G+G FG VY VAIK V +D+ EL Sbjct: 53 TPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNREL---- 108 Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWF----ERPDSFVLIL---ERPEPVQDLF-DFITER 136 +++K+ ++RL +F E+ D L L PE V + + + Sbjct: 109 ------QIMRKLDH--CNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAK 160 Query: 137 GALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA-LLKD 195 L + + +Q+ ++ + H+ G+ HRDIK +N+L+D + LKL DFGS L++ Sbjct: 161 QTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG 220 Query: 196 TVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF 255 + +R Y PE I + S VWS G +L +++ G F D + + V Sbjct: 221 EPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQ-LVEI 279 Query: 256 RQRVSSECQHLIRWCLALRPS-DRPTFEEIQNHPWMQ 291 + + + + IR + P+ F +I+ HPW + Sbjct: 280 IKVLGTPTREQIR---EMNPNYTEFKFPQIKAHPWTK 313 >6GU6-A nrPDB Length = 302 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 61/216 (28%), Positives = 99/216 (45%), Gaps = 10/216 (4%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 +G G +G VY G + VA+K + R+ E T + E+ LLK++ + Sbjct: 15 IGEGTYGVVYKGRHKTTGQVVAMKKI---RLESEEEGVPSTAI-REISLLKELRH--PNI 68 Query: 104 IRLLDWFERPDSFVLILE-RPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCG 162 + L D + LI E ++ D I + L +S+ +Q+L+ + CH+ Sbjct: 69 VSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRR 128 Query: 163 VLHRDIKDENILIDLNRGELKLIDFGSGAL--LKDTVYTDFDGTRVYSPPEWIRYHRYHG 220 VLHRD+K +N+LID ++G +KL DFG + VYT T Y PE + + Sbjct: 129 VLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYS 187 Query: 221 RSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR 256 +WS+G + ++ F D EI + FR Sbjct: 188 TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFR 223 >4QNY-A nrPDB Length = 354 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 86/328 (26%), Positives = 132/328 (40%), Gaps = 66/328 (20%) Query: 8 SLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRV-SDNLPVAI 66 SLA L+A C L+ +Y + ++G+G +G V SDN VA+ Sbjct: 7 SLAELQAEVCR---------------LDDRYLLERIIGAGSYGVVIRARDTKSDNRLVAM 51 Query: 67 KHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERP---DSFVLILERP 123 K V K+ + E+ R+ E+ LL + +R + E P D F ++++ Sbjct: 52 KRVNKEI---FEEVILAKRILREIKLLAHFNDDNIIGLRNILTPEDPENFDHFYIVMDIM 108 Query: 124 EPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELK 183 E DL + L E + F +Q L A+ H+ GV+HRDI NIL++ N +LK Sbjct: 109 ET--DLKQVLRSGQELTEAHIQFFIYQALRALHIIHSAGVIHRDITPANILVNTN-CDLK 165 Query: 184 LIDFGSGALLKDT--VYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDM------ 235 + DFG D TD+ R Y PE + + + VW +G +L ++ Sbjct: 166 ICDFGLAKEENDQGEYMTDYVTMRWYRAPELVMEDKDYSAQIDVWGIGCILGELLGSRPL 225 Query: 236 ---------------VCGDIPFEHDEEII--------------RGQVFFRQR---VSSEC 263 V G P E D + R Q +RQR S E Sbjct: 226 FQGKDRVNQLDKIVDVIG-TPSEEDINSVGSSAAQKYLKKKSHRPQADWRQRYPTASPEA 284 Query: 264 QHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 L+R L P R T + HP+++ Sbjct: 285 LDLLRHMLVFNPKRRITVLQAMRHPFLE 312 >1UA2-A nrPDB Length = 346 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 62/210 (29%), Positives = 101/210 (48%), Gaps = 10/210 (4%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +Y+ LG G F +VY + N VAIK ++ S+ + N T + E+ LL++ Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL-REIKLLQE 68 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQVLEA 154 +S +I LLD F + L+ + E DL I + L +++ L+ Sbjct: 69 LSH--PNIIGLLDAFGHKSNISLVFDFME--TDLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYTDFDGTRVYSPPEW 212 + + H +LHRD+K N+L+D N G LKL DFG + YT TR Y PE Sbjct: 125 LEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPF 242 + R +G +W++G +L +++ +PF Sbjct: 184 LFGARMYGVGVDMWAVGCILAELLL-RVPF 212 >4APC-A nrPDB Length = 350 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 76/273 (27%), Positives = 119/273 (43%), Gaps = 24/273 (8%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 +G G FG D IK + R+S E R EV +L + + Sbjct: 32 IGEGSFGKAILVKSTEDGRQYVIKEINISRMSS-KEREESRR---EVAVLANMKH--PNI 85 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFIT-ERGAL-QEELARSFFWQVLEAVRHCHNC 161 ++ + FE S ++++ E DLF I ++G L QE+ +F Q+ A++H H+ Sbjct: 86 VQYRESFEENGSLYIVMDYCEG-GDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDR 144 Query: 162 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEWIRYHRYH 219 +LHRDIK +NI + + G ++L DFG +L TV GT Y PE Y+ Sbjct: 145 KILHRDIKSQNIFLTKD-GTVQLGDFGIARVLNSTVELARACIGTPYYLSPEICENKPYN 203 Query: 220 GRSAAVWSLGILLYDMVCGDIPFEHDE------EIIRGQV-FFRQRVSSECQHLIRWCLA 272 +S +W+LG +LY++ FE +II G S + + L+ Sbjct: 204 NKS-DIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFK 262 Query: 273 LRPSDRPTFEEIQNHPW----MQDVLLPQETAE 301 P DRP+ I + ++ L PQ AE Sbjct: 263 RNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAE 295 >3QGY-A nrPDB Length = 286 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 69/253 (27%), Positives = 118/253 (46%), Gaps = 25/253 (9%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 +GSG FG V+ G ++ + VAIK +++ +S+ + V M++ K + Sbjct: 35 IGSGQFGLVHLGYWLNKD-KVAIKTIKEGSMSE-DDFIEEAEVMMKLSHPK--------L 84 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFI-TERGALQEELARSFFWQVLEAVRHCHNCG 162 ++L L+ E E L D++ T+RG E V E + + Sbjct: 85 VQLYGVCLEQAPICLVFEFMEH-GCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEAC 143 Query: 163 VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---YSPPEWIRYHRYH 219 V+HRD+ N L+ N+ +K+ DFG + D YT GT+ ++ PE + RY Sbjct: 144 VIHRDLAARNCLVGENQ-VIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYS 202 Query: 220 GRSAAVWSLGILLYDMVC-GDIPFEHD------EEIIRGQVFFRQRV-SSECQHLIRWCL 271 +S VWS G+L++++ G IP+E+ E+I G ++ R+ S+ ++ C Sbjct: 203 SKS-DVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCW 261 Query: 272 ALRPSDRPTFEEI 284 RP DRP F + Sbjct: 262 KERPEDRPAFSRL 274 >1CM8-A nrPDB Length = 367 Score = 72.4 bits (176), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 64/208 (30%), Positives = 102/208 (49%), Gaps = 21/208 (10%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 +GSG +G+V S + VAIK + + S+ R E+ LLK + V Sbjct: 33 VGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSEL----FAKRAYRELRLLKHMRH--ENV 86 Query: 104 IRLLDWF---ERPDSFV-LILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 159 I LLD F E D F L P DL + L E+ + +Q+L+ +R+ H Sbjct: 87 IGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHE-KLGEDRIQFLVYQMLKGLRYIH 145 Query: 160 NCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPE----WIRY 215 G++HRD+K N+ ++ + ELK++DFG A D+ T + TR Y PE W+RY Sbjct: 146 AAGIIHRDLKPGNLAVNED-CELKILDFGL-ARQADSEMTGYVVTRWYRAPEVILNWMRY 203 Query: 216 HRYHGRSAAVWSLGILLYDMVCGDIPFE 243 ++ +WS+G ++ +M+ G F+ Sbjct: 204 ----TQTVDIWSVGCIMAEMITGKTLFK 227 >5F9E-A nrPDB Length = 353 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 66/267 (24%), Positives = 127/267 (47%), Gaps = 20/267 (7%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 +++ +LG G FG V+ N AIK ++KD + + + M + ++ Sbjct: 21 FELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVL----MDDDVECTMVEKRVLSLA 76 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW--QVLEAV 155 + + F+ ++ ++E DL I + + +L+R+ F+ +++ + Sbjct: 77 WEHPFLTHMFCTFQTKENLFFVMEYLNG-GDLMYHI--QSCHKFDLSRATFYAAEIILGL 133 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFG--SGALLKDTVYTDFDGTRVYSPPEWI 213 + H+ G+++RD+K +NIL+D + G +K+ DFG +L D +F GT Y PE + Sbjct: 134 QFLHSKGIVYRDLKLDNILLDKD-GHIKIADFGMCKENMLGDAKTNEFCGTPDYIAPEIL 192 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPFE-HDEEIIRGQV-----FFRQRVSSECQHLI 267 +Y+ S WS G+LLY+M+ G PF DEE + + F+ + + E + L+ Sbjct: 193 LGQKYN-HSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLEKEAKDLL 251 Query: 268 RWCLALRPSDRPTFE-EIQNHPWMQDV 293 P R +I+ HP +++ Sbjct: 252 VKLFVREPEKRLGVRGDIRQHPLFREI 278 >4KS7-A nrPDB Length = 292 Score = 72.4 bits (176), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 56/179 (31%), Positives = 85/179 (47%), Gaps = 19/179 (10%) Query: 133 ITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL 192 I + L EE + VL+A+ + H GV+HRDIK ++IL+ L+ G +KL DFG A Sbjct: 110 IVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLD-GRVKLSDFGFCAQ 168 Query: 193 LKDTV--YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIR 250 + V GT + PE I Y +WSLGI++ +MV G+ P+ D + Sbjct: 169 ISKDVPKRKSLVGTPYWMAPEVISRSLY-ATEVDIWSLGIMVIEMVDGEPPYFSDSPV-- 225 Query: 251 GQVFFRQR------------VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQ 297 Q R R VS + + L P +R T +E+ +HP++ LP+ Sbjct: 226 -QAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTGLPE 283 >5H2U-A nrPDB Length = 267 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 72/260 (27%), Positives = 112/260 (43%), Gaps = 36/260 (13%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME-----VVLLKKVSS 98 LGSG FG V+ G+ D + VAIK + +D + L + + + ++ L V S Sbjct: 14 LGSGYFGEVFEGL-WKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVS 72 Query: 99 GFSGVIRLLDWFERPDSFVLILERPE---PVQDLFDFITERGALQEELARSFFWQVLEAV 155 V + + + L+ + E PV +L D WQV E + Sbjct: 73 VGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIA---------------WQVAEGM 117 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVY--SPPEWI 213 + + +HRD+ NIL+ N K+ DFG L+K+ VY D Y + PE + Sbjct: 118 CYLESQNYIHRDLAARNILVGEN-TLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEAL 176 Query: 214 RYHRYHGRSAAVWSLGILLYDMVC-GDIPF---EHDEEIIRGQVFFRQRVSSEC----QH 265 Y +S VWS GILL++M G +P+ + E +R +R EC Sbjct: 177 SRGHYSTKS-DVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHK 235 Query: 266 LIRWCLALRPSDRPTFEEIQ 285 L+ C P RPTF+ ++ Sbjct: 236 LMLTCWCRDPEQRPTFKALR 255 >5EFQ-A nrPDB Length = 347 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 63/237 (26%), Positives = 109/237 (45%), Gaps = 29/237 (12%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDR------------ISDWGELPNGT 84 ++ + ++G G +G VY VA+K V D I +L + + Sbjct: 12 KFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQS 71 Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGAL--QEE 142 + M+ ++ K + LD+ + +F L+ E + DL + E G + E Sbjct: 72 IINMKEIVTDKEDA--------LDFKKDKGAFYLVFEYMD--HDLMGLL-ESGLVHFNEN 120 Query: 143 LARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL---KDTVYT 199 +SF Q++E + +CH LHRDIK NIL++ NRG++KL DFG L + YT Sbjct: 121 HIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLN-NRGQIKLADFGLARLYSSEESRPYT 179 Query: 200 DFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR 256 + T Y PPE + + + VWS G +L ++ F+ ++E+ + ++ R Sbjct: 180 NKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISR 236 >4E7W-A nrPDB Length = 394 Score = 72.0 bits (175), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 81/310 (26%), Positives = 130/310 (41%), Gaps = 57/310 (18%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 GK E E Y ++G+G FG V+ V + VAIK V +D+ EL Sbjct: 32 GKTGEQREIAYTNCKVIGNGSFGVVFQAKLVESD-EVAIKKVLQDKRFKNREL------- 83 Query: 88 MEVVLLKKVSSGFSGVIRLLDWF-----ERPDSFV-LILER-PEPV-QDLFDFITERGAL 139 +++ + K V+ L +F ++ + F+ L+LE PE V + + + + Sbjct: 84 -QIMRIVK----HPNVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQTM 138 Query: 140 QEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA-LLKDTVY 198 L + + +Q+L ++ + H+ G+ HRDIK +N+L+D G LKLIDFGS L+ Sbjct: 139 PMLLIKLYMYQLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGEPN 198 Query: 199 TDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF---------------- 242 + +R Y PE I + + +WS G ++ +++ G F Sbjct: 199 VSYICSRYYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIKVL 258 Query: 243 ----------------EHDEEIIRGQVF---FRQRVSSECQHLIRWCLALRPSDRPTFEE 283 EH IR F FR R + LI L PS R T E Sbjct: 259 GTPSREQIKTMNPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTAIE 318 Query: 284 IQNHPWMQDV 293 HP+ ++ Sbjct: 319 ALCHPFFDEL 328 >4XEY-B nrPDB Length = 408 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 68/258 (26%), Positives = 118/258 (45%), Gaps = 31/258 (12%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 LG G +G VY G+ +L VA+K +++D + E+ + E ++K++ + Sbjct: 133 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM----EVEEFLK---EAAVMKEIK--HPNL 183 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITE--RGALQEELARSFFWQVLEAVRHCHNC 161 ++LL R F +I E +L D++ E R + + Q+ A+ + Sbjct: 184 VQLLGVCTREPPFYIITEFM-TYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 242 Query: 162 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---YSPPEWIRYHRY 218 +HRD+ N L+ N +K+ DFG L+ YT G + ++ PE + Y+++ Sbjct: 243 NFIHRDLAARNCLVGENH-LVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKF 301 Query: 219 HGRSAAVWSLGILLYDMVC-GDIPFEHDEEIIRGQVF------FRQRVSSEC----QHLI 267 +S VW+ G+LL+++ G P+ I QV+ +R C L+ Sbjct: 302 SIKS-DVWAFGVLLWEIATYGMSPYPG---IDLSQVYELLEKDYRMERPEGCPEKVYELM 357 Query: 268 RWCLALRPSDRPTFEEIQ 285 R C PSDRP+F EI Sbjct: 358 RACWQWNPSDRPSFAEIH 375 >6NPU-A nrPDB Length = 298 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 68/257 (26%), Positives = 118/257 (45%), Gaps = 31/257 (12%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 LG G +G VY G+ +L VA+K +++D + E+ + E ++K++ + Sbjct: 34 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM----EVEEFLK---EAAVMKEIKH--PNL 84 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITE--RGALQEELARSFFWQVLEAVRHCHNC 161 ++LL R F +I E +L D++ E R + + Q+ A+ + Sbjct: 85 VQLLGVCTREPPFYIITEFM-TYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 143 Query: 162 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---YSPPEWIRYHRY 218 +HRD+ N L+ N +K+ DFG L+ YT G + ++ PE + Y+++ Sbjct: 144 NFIHRDLAARNCLVGENHL-VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKF 202 Query: 219 HGRSAAVWSLGILLYDMVC-GDIPFEHDEEIIRGQVF------FRQRVSSEC----QHLI 267 +S VW+ G+LL+++ G P+ I QV+ +R C L+ Sbjct: 203 SIKS-DVWAFGVLLWEIATYGMSPYPG---IDLSQVYELLEKDYRMERPEGCPEKVYELM 258 Query: 268 RWCLALRPSDRPTFEEI 284 R C PSDRP+F EI Sbjct: 259 RACWQWNPSDRPSFAEI 275 >6E9W-A nrPDB Length = 443 Score = 71.6 bits (174), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 61/212 (28%), Positives = 101/212 (47%), Gaps = 29/212 (13%) Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCG 162 V++L F+ D ++ ++ P DL + ++ + E+ AR + +V+ A+ H+ G Sbjct: 164 VVQLFYAFQ-DDRYLYMVMEYMPGGDLVNLMSNYD-VPEKWARFYTAEVVLALDAIHSMG 221 Query: 163 VLHRDIKDENILIDLNRGELKLIDFGS-------GALLKDTVYTDFDGTRVYSPPEWIRY 215 +HRD+K +N+L+D G LKL DFG+ G + DT GT Y PE ++ Sbjct: 222 FIHRDVKPDNMLLD-KSGHLKLADFGTCMKMNKEGMVRCDTAV----GTPDYISPEVLKS 276 Query: 216 HR---YHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR----------VSSE 262 Y+GR WS+G+ LY+M+ GD PF D + + +S E Sbjct: 277 QGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKE 336 Query: 263 CQHLIRWCLALRPS--DRPTFEEIQNHPWMQD 292 ++LI L R R EEI+ H + ++ Sbjct: 337 AKNLICAFLTDREVRLGRNGVEEIKRHLFFKN 368 >4NIF-A nrPDB Length = 333 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 75/284 (26%), Positives = 114/284 (40%), Gaps = 42/284 (14%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 Y V +G G + + + N+ A+K ++K + R P E + + Sbjct: 10 YVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSK-----------RDPSEEIEILLRY 58 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 +I L D ++ L+ E +L D I + E A + + V + Sbjct: 59 GQHPNIITLKDVYDDGKHVYLVTELMRG-GELLDKILRQKFFSEREASFVLHTIGKTVEY 117 Query: 158 CHNCGVLHRDIKDENILIDLNRGE---LKLIDFG-------SGALLKDTVYTDFDGTRVY 207 H+ GV+HRD+K NIL G L++ DFG LL Y T + Sbjct: 118 LHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCY-----TANF 172 Query: 208 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-----EEIIR--GQVFFR---- 256 PE ++ Y +WSLGILLY M+ G PF + EEI+ G F Sbjct: 173 VAPEVLKRQGYD-EGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGG 231 Query: 257 --QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM-QDVLLPQ 297 VS + L+ L + P R T +++ HPW+ Q LPQ Sbjct: 232 NWNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQ 275 >4EWQ-A nrPDB Length = 383 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 57/230 (24%), Positives = 107/230 (46%), Gaps = 25/230 (10%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +YQ +GSG +GSV + L VA+K + + + + + R E+ LLK + Sbjct: 46 RYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP----FQSIIHAKRTYRELRLLKHM 101 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA----------LQEELARS 146 VI LLD F S E D++ GA L ++ + Sbjct: 102 KH--ENVIGLLDVFTPARSL-------EEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQF 152 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV 206 +Q+L +++ H+ ++HRD+K N+ ++ + ELK++DFG D + T + TR Sbjct: 153 LIYQILRGLKYIHSADIIHRDLKPSNLAVNED-CELKILDFGLARHTDDEM-TGYVATRW 210 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR 256 Y PE + ++ ++ +WS+G ++ +++ G F + I + ++ R Sbjct: 211 YRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILR 260 >5DBX-A nrPDB Length = 328 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 68/283 (24%), Positives = 118/283 (41%), Gaps = 36/283 (12%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRI-SDWGELPNGTRVPMEVVLLKKV 96 Y++ ++GSG V + + VAIK + ++ + EL + + V Sbjct: 13 YELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVV 72 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-----ALQEELARSFFWQV 151 + S V++ W V+ L + D+ +I RG L+E + + +V Sbjct: 73 TYYTSFVVKDELWL------VMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEV 126 Query: 152 LEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL-------KDTVYTDFDGT 204 LE + + H G +HRD+K NIL+ + G +++ DFG A L ++ V DF GT Sbjct: 127 LEGLDYLHRNGQIHRDLKAGNILLGED-GSVQIADFGVSAFLATGGDVTRNKVRKDFVGT 185 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF-------------EHDEEIIRG 251 + PE + R + A +WS GI ++ G P+ ++D + Sbjct: 186 PCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLET 245 Query: 252 QV---FFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 V ++ + L+ CL PS RPT E+ + Q Sbjct: 246 GVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQ 288 >2PL0-A nrPDB Length = 289 Score = 71.2 bits (173), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 68/258 (26%), Positives = 119/258 (46%), Gaps = 31/258 (12%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 LG+G FG V+ G + + VA+K +++ +S L M+ + +++ ++ V Sbjct: 31 LGAGQFGEVWMGY-YNGHTKVAVKSLKQGSMSPDAFLAEANL--MKQLQHQRLVRLYAVV 87 Query: 104 ----IRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 159 I ++ + S V L+ P ++ + + + A Q+ E + Sbjct: 88 TQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAA-----------QIAEGMAFIE 136 Query: 160 NCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---YSPPEWIRYH 216 +HRD++ NIL+ + K+ DFG L++D YT +G + ++ PE I Y Sbjct: 137 ERNYIHRDLRAANILVS-DTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYG 195 Query: 217 RYHGRSAAVWSLGILLYDMVC-GDIPF------EHDEEIIRGQVFFR-QRVSSECQHLIR 268 + +S VWS GILL ++V G IP+ E + + RG R E L+R Sbjct: 196 TFTIKSD-VWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMR 254 Query: 269 WCLALRPSDRPTFEEIQN 286 C RP DRPTF+ +++ Sbjct: 255 LCWKERPEDRPTFDYLRS 272 >4IAN-A nrPDB Length = 358 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 66/223 (29%), Positives = 103/223 (46%), Gaps = 26/223 (11%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNL----PVAIKHVEKDRISDWGELPNGTRVP 87 E L+ +Y V G G F +V +R DN VA+K + + EL T + Sbjct: 26 EVLDKRYNVYGYTGQGVFSNV---VRARDNARANQEVAVKIIRNN------ELMQKTGLK 76 Query: 88 MEVVLLKKVSSGFSG----VIRLLDWFERPDSFVLILERPEPVQ-DLFDFITERG---AL 139 E+ LKK++ +RL F L+ E P+ +L + + + G L Sbjct: 77 -ELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFE---PLSMNLREVLKKYGKDVGL 132 Query: 140 QEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT 199 + RS+ Q+ A++ C +LH DIK +NIL++ ++ LKL DFGS + + D T Sbjct: 133 HIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDIT 192 Query: 200 DFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF 242 + +R Y PE I Y +WS+G LY++ G I F Sbjct: 193 PYLVSRFYRAPEIIIGKSY-DYGIDMWSVGCTLYELYTGKILF 234 >3A8W-A nrPDB Length = 345 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 56/190 (29%), Positives = 96/190 (50%), Gaps = 27/190 (14%) Query: 128 DLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDF 187 DL + + L EE AR + ++ A+ + H G+++RD+K +N+L+D + G +KL D+ Sbjct: 96 DLMFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLD-SEGHIKLTDY 154 Query: 188 G---SGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF-- 242 G G DT T F GT Y PE +R Y G S W+LG+L+++M+ G PF Sbjct: 155 GMCKEGLRPGDTTST-FCGTPNYIAPEILRGEDY-GFSVDWWALGVLMFEMMAGRSPFDI 212 Query: 243 --------EHDEE-----IIRGQVFFRQRVSSECQHLIRWCLALRPSDR------PTFEE 283 ++ E+ I+ Q+ + +S + +++ L P +R F + Sbjct: 213 VGSSDNPDQNTEDYLFQVILEKQIRIPRSLSVKAASVLKSFLNKDPKERLGCHPQTGFAD 272 Query: 284 IQNHPWMQDV 293 IQ HP+ ++V Sbjct: 273 IQGHPFFRNV 282 >4AN9-A nrPDB Length = 301 Score = 71.2 bits (173), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 46/142 (32%), Positives = 73/142 (51%), Gaps = 20/142 (14%) Query: 163 VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRS 222 ++HRD+K NIL++ +RGE+KL DFG L D + +F GTR Y PE ++ Y +S Sbjct: 129 IMHRDVKPSNILVN-SRGEIKLCDFGVSGQLIDEMANEFVGTRSYMSPERLQGTHYSVQS 187 Query: 223 AAVWSLGILLYDMVCGDIP------FEHDEEIIR-------GQVFFRQRVSSECQHLIRW 269 +WS+G+ L +M G P FE + I+ VF S E Q + Sbjct: 188 -DIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVNEPPPKLPSAVF-----SLEFQDFVNK 241 Query: 270 CLALRPSDRPTFEEIQNHPWMQ 291 CL P++R +++ H +++ Sbjct: 242 CLIKNPAERADLKQLMVHAFIK 263 >2XIK-A nrPDB Length = 294 Score = 70.9 bits (172), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 71/259 (27%), Positives = 118/259 (45%), Gaps = 26/259 (10%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 +G G FG VY GI VAIK ++ + D + E+ +L + S + + Sbjct: 27 IGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAED-----EIEDIQQEITVLSQCDSPY--I 79 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGV 163 R + + +I+E L D + + G L+E + ++L+ + + H+ Sbjct: 80 TRYFGSYLKSTKLWIIMEYLGGGSAL-DLL-KPGPLEETYIATILREILKGLDYLHSERK 137 Query: 164 LHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY--TDFDGTRVYSPPEWIRYHRYHGR 221 +HRDIK N+L+ +G++KL DFG L DT F GT + PE I+ Y + Sbjct: 138 IHRDIKAANVLLS-EQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDFK 196 Query: 222 SAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSS----ECQH------LIRWCL 271 A +WSLGI ++ G+ P + ++ +V F +S E QH + CL Sbjct: 197 -ADIWSLGITAIELAKGEPP---NSDLHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACL 252 Query: 272 ALRPSDRPTFEEIQNHPWM 290 P RPT +E+ H ++ Sbjct: 253 NKDPRFRPTAKELLKHKFI 271 >4CSV-A nrPDB Length = 275 Score = 70.9 bits (172), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 70/267 (26%), Positives = 120/267 (44%), Gaps = 27/267 (10%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 LGSG FG VY G + N+ VA+K +++ +S E ++KK+ + Sbjct: 19 LGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMSV-------EEFLQEAQIMKKLKH--PNL 69 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFI--TERGALQEELARSFFWQVLEAVRHCHNC 161 ++L + +I E L D++ E + + QV + + + Sbjct: 70 VQLYGVCTKEPPIYIITEYMSH-GSLLDYLRDCEGHTVNAQALLDMAAQVASGMAYLESQ 128 Query: 162 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---YSPPEWIRYHRY 218 +HRD+ N L+ N +K+ DFG L+ + YT G + ++ PE I Y+R+ Sbjct: 129 NFIHRDLAARNCLVGENN-VVKVADFGLARLINEDEYTARAGAKFPIKWTAPEAISYNRF 187 Query: 219 HGRSAAVWSLGILLYDMVC-GDIPF------EHDEEIIRGQVFFR-QRVSSECQHLIRWC 270 +S VW+ GILL+++ G +P+ E E++ RG R Q E L+ C Sbjct: 188 SIKS-DVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRMPRPQGCPEEIYELMLQC 246 Query: 271 LALRPSDRPTFEEIQNHPWMQDVLLPQ 297 P +RPTF E + ++ + LP+ Sbjct: 247 WNKSPEERPTFAETLHA--LETMFLPE 271 >3ALO-A nrPDB Length = 327 Score = 70.9 bits (172), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 57/181 (31%), Positives = 84/181 (46%), Gaps = 23/181 (12%) Query: 138 ALQEELARSFFWQVLEAVRHC-HNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKD 195 + EE+ ++A+ H N ++HRDIK NIL+D G +KL DFG SG L+ Sbjct: 121 VIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLD-RSGNIKLCDFGISGQLVDS 179 Query: 196 TVYTDFDGTRVYSPPEWI----RYHRYHGRSAAVWSLGILLYDMVCGDIP-------FEH 244 T G R Y PE I Y RS VWSLGI LY++ G P F+ Sbjct: 180 IAKTRDAGCRPYMAPERIDPSASRQGYDVRSD-VWSLGITLYELATGRFPYPKWNSVFDQ 238 Query: 245 DEEIIRG-----QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQET 299 ++++G + S + + CL S RP ++E+ HP+ +L+ +E Sbjct: 239 LTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPF---ILMYEER 295 Query: 300 A 300 A Sbjct: 296 A 296 >2FO0-A nrPDB Length = 495 Score = 70.5 bits (171), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 66/258 (25%), Positives = 115/258 (44%), Gaps = 31/258 (12%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 LG G +G VY G+ +L VA+K +++D + E ++K++ + Sbjct: 225 LGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEV-------EEFLKEAAVMKEIK--HPNL 275 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITE--RGALQEELARSFFWQVLEAVRHCHNC 161 ++LL R F +I E +L D++ E R + + Q+ A+ + Sbjct: 276 VQLLGVCTREPPFYIITEF-MTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 334 Query: 162 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---YSPPEWIRYHRY 218 +HR++ N L+ N +K+ DFG L+ YT G + ++ PE + Y+++ Sbjct: 335 NFIHRNLAARNCLVGENH-LVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKF 393 Query: 219 HGRSAAVWSLGILLYDMVC-GDIPFEHDEEIIRGQVF------FRQRVSSEC----QHLI 267 +S VW+ G+LL+++ G P+ I QV+ +R C L+ Sbjct: 394 SIKS-DVWAFGVLLWEIATYGMSPYPG---IDLSQVYELLEKDYRMERPEGCPEKVYELM 449 Query: 268 RWCLALRPSDRPTFEEIQ 285 R C PSDRP+F EI Sbjct: 450 RACWQWNPSDRPSFAEIH 467 >4NST-A nrPDB Length = 351 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 59/229 (25%), Positives = 105/229 (45%), Gaps = 13/229 (5%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 ++ + ++G G +G VY VA+K V D + + + + L+ + Sbjct: 14 KFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRS 73 Query: 97 SSGFSGVIR----LLDWFERPDSFVLILERPEPVQDLFDFITERGALQ--EELARSFFWQ 150 ++ LD+ + +F L+ E + DL + E G + E+ +SF Q Sbjct: 74 VVNMKEIVTDKQDALDFKKDKGAFYLVFEYMD--HDLMGLL-ESGLVHFSEDHIKSFMKQ 130 Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL---KDTVYTDFDGTRVY 207 ++E + +CH LHRDIK NIL++ N G++KL DFG L + YT+ T Y Sbjct: 131 LMEGLEYCHKKNFLHRDIKCSNILLN-NSGQIKLADFGLARLYNSEESRPYTNKVITLWY 189 Query: 208 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR 256 PPE + + + VWS G +L ++ F+ + E+ + ++ R Sbjct: 190 RPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISR 238 >5Z33-A nrPDB Length = 425 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 60/213 (28%), Positives = 104/213 (48%), Gaps = 14/213 (6%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 ++ +Y V LG G +G V + + + VAIK V + + + R E+ LL Sbjct: 29 VDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKV----TNVFSKKILAKRALREIKLL 84 Query: 94 KKVSSGFSGVIRLLDW-FERPDSFVLILERPEPVQ-DLFDFITERGALQEELARSFFWQV 151 + G + L D RPD+F E ++ DL I L + +SF +Q+ Sbjct: 85 QHFR-GHRNITCLYDMDIPRPDNFNETYLYEELMECDLAAIIRSGQPLTDAHFQSFIYQI 143 Query: 152 LEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL-----KDTVY-TDFDGTR 205 L +++ H+ VLHRD+K N+L++ + ELK+ DFG ++ Y T++ TR Sbjct: 144 LCGLKYIHSANVLHRDLKPGNLLVNAD-CELKICDFGLARGFSVDPEENAGYMTEYVATR 202 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCG 238 Y PE + + + ++ VWS+G +L +++ G Sbjct: 203 WYRAPEIMLSFQSYTKAIDVWSVGCILAELLGG 235 >4LFI-A nrPDB Length = 374 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 44/150 (29%), Positives = 76/150 (50%), Gaps = 7/150 (4%) Query: 98 SGFSGVIRLLDWFERPDSFV--LILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 +G + +I L D + P S L+ E + V DF L + R + +++L+A+ Sbjct: 130 NGHANIIHLFDIIKDPISKTPALVFEYVDNV----DFRILYPKLTDLEIRFYMFELLKAL 185 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRVYSPPEWIR 214 +CH+ G++HRD+K N++ID +L+LID+G + Y +R + PE + Sbjct: 186 DYCHSMGIMHRDVKPHNVMIDHKNKKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLV 245 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPFEH 244 +R + S +WS G +L M+ PF H Sbjct: 246 DYRMYDYSLDLWSFGTMLASMIFKREPFFH 275 >4JG6-A nrPDB Length = 355 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 65/276 (23%), Positives = 109/276 (39%), Gaps = 41/276 (14%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 Y+V +G G + I + N+ A+K ++K + R P E + + Sbjct: 37 YEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSK-----------RDPTEEIEILLRY 85 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 +I L D ++ +V ++ +L D I + E A + + + + V + Sbjct: 86 GQHPNIITLKDVYD-DGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEY 144 Query: 158 CHNCGVLHRDIKDENILIDLNRGE---LKLIDFG-------SGALLKDTVYTDFDGTRVY 207 H GV+HRD+K NIL G +++ DFG LL Y T + Sbjct: 145 LHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCY-----TANF 199 Query: 208 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR----------- 256 PE + Y + +WSLG+LLY M+ G PF + + ++ R Sbjct: 200 VAPEVLERQGYDA-ACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGG 258 Query: 257 --QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 VS + L+ L + P R T + HPW+ Sbjct: 259 YWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 294 >3NYO-A nrPDB Length = 576 Score = 70.1 bits (170), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 80/300 (26%), Positives = 131/300 (43%), Gaps = 41/300 (13%) Query: 37 QYQVGPLLGSGGFGSVYS-GIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 QY+V LG GGFG V + +R + + K +K GE E +L+K Sbjct: 188 QYRV---LGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGE----AMALNEKQILEK 240 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW--QVLE 153 V+S F V+ L +E D+ L+L DL I G AR+ F+ ++ Sbjct: 241 VNSRF--VVSLAYAYETKDALCLVLTLMNG-GDLKFHIYHMGQAGFPEARAVFYAAEICC 297 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG------SGALLKDTVYTDFDGTRVY 207 + H +++RD+K ENIL+D + G +++ D G G +K V GT Y Sbjct: 298 GLEDLHRERIVYRDLKPENILLD-DHGHIRISDLGLAVHVPEGQTIKGRV-----GTVGY 351 Query: 208 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVF----------FRQ 257 PE ++ RY S W+LG LLY+M+ G PF+ ++ I+ + + + Sbjct: 352 MAPEVVKNERYTF-SPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSE 410 Query: 258 RVSSECQHLIRWCLALRPSDR-----PTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPS 312 R S + + L L P++R + E++ HP + + + A + P P Sbjct: 411 RFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQ 470 >6E4F-A nrPDB Length = 290 Score = 69.7 bits (169), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 68/251 (27%), Positives = 120/251 (47%), Gaps = 25/251 (9%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 LG+G FG V G + VAIK +++ +S+ E +V M + K V GV Sbjct: 39 LGTGQFGVVKYG-KWRGQYDVAIKMIKEGSMSE-DEFIEEAKVMMNLSHEKLVQ--LYGV 94 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSFFWQVLEAVRHCHNCG 162 +RP + I+ L +++ E R Q + V EA+ + + Sbjct: 95 CTK----QRP---IFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQ 147 Query: 163 VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---YSPPEWIRYHRYH 219 LHRD+ N L++ ++G +K+ DFG + D YT G++ +SPPE + Y ++ Sbjct: 148 FLHRDLAARNCLVN-DQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFS 206 Query: 220 GRSAAVWSLGILLYDMVC-GDIPFEH------DEEIIRGQVFFRQRVSSECQHLIRW-CL 271 +S +W+ G+L++++ G +P+E E I +G +R ++SE + I + C Sbjct: 207 SKS-DIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCW 265 Query: 272 ALRPSDRPTFE 282 + +RPTF+ Sbjct: 266 HEKADERPTFK 276 >3DAK-A nrPDB Length = 290 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 68/290 (23%), Positives = 113/290 (38%), Gaps = 50/290 (17%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRI-SDWGELPNGTRVPMEVVLLKKV 96 Y++ ++GSG V + VAIK + ++ + EL + + V Sbjct: 12 YELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIV 71 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-----ALQEELARSFFWQV 151 S S V++ W V+ L V D+ I +G L E + +V Sbjct: 72 SYYTSFVVKDELWL------VMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREV 125 Query: 152 LEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL-------KDTVYTDFDGT 204 LE + + H G +HRD+K NIL+ + G +++ DFG A L ++ V F GT Sbjct: 126 LEGLEYLHKNGQIHRDVKAGNILLGED-GSVQIADFGVSAFLATGGDITRNKVRKTFVGT 184 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE--------------------- 243 + PE + R + A +WS GI ++ G P+ Sbjct: 185 PCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLET 244 Query: 244 --HDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 D+E+++ + + +I CL P RPT E+ H + Q Sbjct: 245 GVQDKEMLK-------KYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQ 287 >3ZDU-A nrPDB Length = 325 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 46/178 (25%), Positives = 84/178 (47%), Gaps = 16/178 (8%) Query: 104 IRLLDWFERPD--SFVLILERPEPVQDLFDFITER---------GALQEELARSFFWQVL 152 I+ L F + + + + + + + +F+FI L+ + R + +Q+L Sbjct: 52 IKFLKQFHHENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCHGLESKRLRKYLFQIL 111 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPP 210 A+ + H+ ++HRDIK ENIL+ G KL DFG L +Y D TR Y P Sbjct: 112 RAIDYLHSNNIIHRDIKPENILVS-QSGITKLCDFGFARTLAAPGDIYDDEVATRWYRAP 170 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGD--IPFEHDEEIIRGQVFFRQRVSSECQHL 266 E + +G+ +W+LG ++ +M G+ +P D +++ V +S Q++ Sbjct: 171 ELVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNI 228 >6HMD-A nrPDB Length = 365 Score = 69.3 bits (168), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 54/216 (25%), Positives = 101/216 (46%), Gaps = 17/216 (7%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 + YQ+ LG G + V+ I +++N +R+ P + V + Sbjct: 52 QDDYQLVRKLGRGKYSEVFEAINITNN----------ERVVVKILKPVKKKKIKREVKIL 101 Query: 95 KVSSGFSGVIRLLDWFERPDSFV--LILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 + G + +I+L+D + P S L+ E DF L + R + +++L Sbjct: 102 ENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT----DFKQLYQILTDFDIRFYMYELL 157 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV-YTDFDGTRVYSPPE 211 +A+ +CH+ G++HRD+K N++ID + +L+LID+G Y +R + PE Sbjct: 158 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE 217 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE 247 + ++ + S +WSLG +L M+ PF H ++ Sbjct: 218 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQD 253 >3E3P-A nrPDB Length = 360 Score = 68.6 bits (166), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 65/251 (25%), Positives = 119/251 (47%), Gaps = 32/251 (12%) Query: 20 LHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGE 79 L+A A + ++ ++ ++QV + G G FG+V G S + VAIK V +D E Sbjct: 8 LNAAAAADERSRKEMD-RFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNRE 66 Query: 80 LPNGTRVPMEVVLLKKVSSGFSGVIRLLDWF------ERPDSFVLILERPEPVQDLF--- 130 L ++ ++ +L +++L +F +R D ++ ++ E V D Sbjct: 67 L----QIMQDLAVLHH-----PNIVQLQSYFYTLGERDRRDIYLNVVM--EYVPDTLHRC 115 Query: 131 --DFITERGALQEELARSFFWQVLEAV--RHCHNCGVLHRDIKDENILIDLNRGELKLID 186 ++ + A L + F +Q++ ++ H + V HRDIK N+L++ G LKL D Sbjct: 116 CRNYYRRQVAPPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCD 175 Query: 187 FGSGALLKDT-VYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD 245 FGS L + + +R Y PE I ++++ + +WS+G + +M+ G+ F D Sbjct: 176 FGSAKKLSPSEPNVAYICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGD 235 Query: 246 E------EIIR 250 EI+R Sbjct: 236 NSAGQLHEIVR 246 >4ZSG-A nrPDB Length = 347 Score = 68.6 bits (166), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 55/211 (26%), Positives = 97/211 (45%), Gaps = 17/211 (8%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +Y++ +G+G +G V S R VAIK + + + + N R E+ +LK Sbjct: 8 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIP----NAFDVVTNAKRTLRELKILKHF 63 Query: 97 SS----GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 ++R + S ++L+ E DL I L E R F +Q+L Sbjct: 64 KHDNIIAIKDILRPTVPYGEFKSVYVVLDLME--SDLHQIIHSSQPLTLEHVRYFLYQLL 121 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT------VYTDFDGTRV 206 +++ H+ V+HRD+K N+L++ N ELK+ DFG L + T++ TR Sbjct: 122 RGLKYMHSAQVIHRDLKPSNLLVNEN-CELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 180 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC 237 Y PE + + ++ +WS+G + +M+ Sbjct: 181 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLA 211 >3E7O-A nrPDB Length = 360 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 68/279 (24%), Positives = 122/279 (43%), Gaps = 35/279 (12%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +YQ +GSG G V + + VA+K + + + + R E+VLLK V Sbjct: 23 RYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP----FQNQTHAKRAYRELVLLKCV 78 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA---------LQEELARSF 147 + +I LL+ F + E QD++ + A L E Sbjct: 79 NH--KNIISLLNVFTPQKTL-------EEFQDVYLVMELMDANLCQVIHMELDHERMSYL 129 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDGTRV 206 +Q+L ++H H+ G++HRD+K NI++ + LK++DFG + + + T + TR Sbjct: 130 LYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLARTASTNFMMTPYVVTRY 188 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHL 266 Y PE I Y + +WS+G ++ ++V G + F+ + I + Q + + + Sbjct: 189 YRAPEVILGMGYK-ENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFM 247 Query: 267 IRWCLALRPS------DRPTFEEIQNHPWMQDVLLPQET 299 AL+P+ +RP + I D + P E+ Sbjct: 248 A----ALQPTVRNYVENRPAYPGIAFEELFPDWIFPSES 282 >4FIE-A nrPDB Length = 423 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 54/173 (31%), Positives = 87/173 (50%), Gaps = 14/173 (8%) Query: 129 LFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG 188 L D +T +E++A + VL+A+ H GV+HRDIK ++IL+ + G +KL DFG Sbjct: 235 LTDIVTHTRMNEEQIA-AVCLAVLQALSVLHAQGVIHRDIKSDSILLTHD-GRVKLSDFG 292 Query: 189 SGALLKDTV--YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE 246 A + V GT + PE I Y G +WSLGI++ +MV G+ P+ ++ Sbjct: 293 FCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWSLGIMVIEMVDGEPPYFNEP 351 Query: 247 -----EIIRGQVFFR----QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 ++IR + R +VS + + L P+ R T E+ HP++ Sbjct: 352 PLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 404 >4O2Z-A nrPDB Length = 377 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 57/209 (27%), Positives = 102/209 (48%), Gaps = 18/209 (8%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 S+Y + +LG G +G S + V+IK +D D + +G RV E+ +++ Sbjct: 45 SKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKC-RDVFRD---VEDGKRVLREIDMMRF 100 Query: 96 VS-SGFSGVIRLLDWFERP-----DSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 V+ +L +R D +V+ P D+ + R L+E + F + Sbjct: 101 FHHENLLNVVNILPPLKREYHSFEDVYVVT---PLMDVDMNVVLRSRQVLEESHMQYFVY 157 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY---TDFDGTRV 206 Q+L +++ H+ V HRD+K N++ +++ ELK+IDFG + D Y TD+ TR Sbjct: 158 QILRGLKYLHSANVAHRDLKPANLVTNIS-CELKIIDFGLSRSV-DVPYSELTDYVITRW 215 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDM 235 Y PPE + + + + +WS+G + +M Sbjct: 216 YRPPELLLENTNYSTAVDIWSVGCIFAEM 244 >4IC8-A nrPDB Length = 442 Score = 68.6 bits (166), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 55/211 (26%), Positives = 97/211 (45%), Gaps = 17/211 (8%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +Y++ +G+G +G V S R VAIK + + + + N R E+ +LK Sbjct: 56 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIP----NAFDVVTNAKRTLRELKILKHF 111 Query: 97 SS----GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 ++R + S ++L+ E DL I L E R F +Q+L Sbjct: 112 KHDNIIAIKDILRPTVPYGEFKSVYVVLDLME--SDLHQIIHSSQPLTLEHVRYFLYQLL 169 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT------VYTDFDGTRV 206 +++ H+ V+HRD+K N+L++ N ELK+ DFG L + T++ TR Sbjct: 170 RGLKYMHSAQVIHRDLKPSNLLVNEN-CELKIGDFGMARGLCTSPAEHQYFMTEYVATRW 228 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC 237 Y PE + + ++ +WS+G + +M+ Sbjct: 229 YRAPELMLSLHEYTQAIDLWSVGCIFGEMLA 259 >5O2C-A nrPDB Length = 380 Score = 68.2 bits (165), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 60/281 (21%), Positives = 119/281 (42%), Gaps = 39/281 (13%) Query: 44 LGSGGFGSVYSGIRVSDNLPVA--------IKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 LG G F +VY G+ + VA + E+ R + E+ G + P Sbjct: 33 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHP-------- 84 Query: 96 VSSGFSGVIRLLDWFE---RPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 ++R D +E + ++++ L ++ ++ ++ RS+ Q+L Sbjct: 85 ------NIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQIL 138 Query: 153 EAVR--HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPP 210 + ++ H ++HRD+K +NI I G +K+ D G L++ + GT + P Sbjct: 139 KGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAP 198 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF---EHDEEIIR------GQVFFRQRVSS 261 E Y ++ S V++ G+ + +M + P+ ++ +I R F + Sbjct: 199 EM--YEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDP 256 Query: 262 ECQHLIRWCLALRPSDRPTFEEIQNHPWM-QDVLLPQETAE 301 E + +I C+ S+R + ++ NH + +D L E AE Sbjct: 257 EVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAE 297 >4JDH-A nrPDB Length = 346 Score = 68.2 bits (165), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 54/173 (31%), Positives = 87/173 (50%), Gaps = 14/173 (8%) Query: 129 LFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG 188 L D +T +E++A + VL+A+ H GV+HRDIK ++IL+ + G +KL DFG Sbjct: 158 LTDIVTHTRMNEEQIA-AVCLAVLQALSVLHAQGVIHRDIKSDSILLT-HDGRVKLSDFG 215 Query: 189 SGALLKDTV--YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE 246 A + V GT + PE I Y G +WSLGI++ +MV G+ P+ ++ Sbjct: 216 FCAQVSKEVPRRKSLVGTPYWMAPELISRLPY-GPEVDIWSLGIMVIEMVDGEPPYFNEP 274 Query: 247 -----EIIRGQVFFR----QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 ++IR + R +VS + + L P+ R T E+ HP++ Sbjct: 275 PLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 327 >4XI2-A nrPDB Length = 446 Score = 67.8 bits (164), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 67/251 (26%), Positives = 119/251 (47%), Gaps = 25/251 (9%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 LG+G FG V G + VAIK + + +S+ E +V M + K V GV Sbjct: 195 LGTGQFGVVKYG-KWRGQYDVAIKMIREGSMSE-DEFIEEAKVMMNLSHEKLVQ--LYGV 250 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSFFWQVLEAVRHCHNCG 162 +RP + I+ L +++ E R Q + V EA+ + + Sbjct: 251 CTK----QRP---IFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQ 303 Query: 163 VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---YSPPEWIRYHRYH 219 LHRD+ N L++ ++G +K+ DFG + D YT G++ +SPPE + Y ++ Sbjct: 304 FLHRDLAARNCLVN-DQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFS 362 Query: 220 GRSAAVWSLGILLYDMVC-GDIPFEH------DEEIIRGQVFFRQRVSSECQHLIRW-CL 271 +S +W+ G+L++++ G +P+E E I +G +R ++SE + I + C Sbjct: 363 SKS-DIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCW 421 Query: 272 ALRPSDRPTFE 282 + +RP+F+ Sbjct: 422 HEKADERPSFK 432 >4LG4-A nrPDB Length = 299 Score = 67.8 bits (164), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 72/276 (26%), Positives = 124/276 (44%), Gaps = 30/276 (10%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 K+P E + V LG G +GSV+ I VAIK V + SD E+ E+ Sbjct: 7 KQP-EEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE--SDLQEIIK------EI 57 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILER--PEPVQDLFDFITERGALQEELARSFF 148 ++++ S + V++ + + +++E V D+ + + +++E+A + Sbjct: 58 SIMQQCDSPY--VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR-LRNKTLIEDEIA-TIL 113 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY--TDFDGTRV 206 L+ + + H +HR+IK NIL++ G KL DFG L DT+ GT Sbjct: 114 KSTLKGLEYLHFMRKIHRNIKAGNILLN-TEGHAKLADFGVAGQLTDTMAKRNTVIGTPF 172 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVF--------FRQR 258 + PE I+ Y+ A +WSLGI +M G P+ D +R FR+ Sbjct: 173 WMAPEVIQEIGYNC-VADIWSLGITSIEMAEGKPPYA-DIHPMRAIFMIPTNPPPTFRKP 230 Query: 259 V--SSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 S + ++ CL P R T ++ HP++++ Sbjct: 231 ELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKN 266 >2Q0N-A nrPDB Length = 301 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 76/275 (27%), Positives = 131/275 (47%), Gaps = 27/275 (9%) Query: 27 PGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRV 86 PG + L++ ++G GS G + + +R S L VA+K ++ + L N Sbjct: 24 PGDPRSYLDNFIKIGE--GSTGIVCIAT-VRSSGKL-VAVKKMDLRKQQRRELLFN---- 75 Query: 87 PMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARS 146 EVV+++ V+ + + + D +++E E L D +T +E++A + Sbjct: 76 --EVVIMRDYQ--HENVVEMYNSYLVGDELWVVMEFLEG-GALTDIVTHTRMNEEQIA-A 129 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGT 204 VL+A+ H GV+HRDIK ++IL+ + G +KL DFG A + V GT Sbjct: 130 VCLAVLQALSVLHAQGVIHRDIKSDSILLT-HDGRVKLSDFGFCAQVSKEVPRRKSLVGT 188 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE-----EIIRGQVFFR--- 256 + PE I Y G +WSLGI++ +MV G+ P+ ++ ++IR + R Sbjct: 189 PYWMAPELISRLPY-GPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKN 247 Query: 257 -QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 +VS + + L P+ R T E+ HP++ Sbjct: 248 LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 282 >3ORP-A nrPDB Length = 311 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 64/264 (24%), Positives = 107/264 (40%), Gaps = 27/264 (10%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 L +Y++G +LG GG V+ + D+ VA+K + D D R L Sbjct: 10 LSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFYLRFRREAQNAAAL 69 Query: 94 KKVSSGFSGVIRLLDWFERPDSF----VLILERPEPVQDLFDFITERGALQEELARSFFW 149 ++ + D E +++E + V L D + G + + A Sbjct: 70 N-----HPAIVAVYDTGEAETPAGPLPYIVMEYVDGVT-LRDIVHTEGPMTPKRAIEVIA 123 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-----TVYTDFDGT 204 +A+ H G++HRD+K NI+I +K++DFG + D T GT Sbjct: 124 DACQALNFSHQNGIIHRDVKPANIMISATNA-VKVMDFGIARAIADSGNSVTQTAAVIGT 182 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR------ 258 Y PE R RS V+SLG +LY+++ G+ PF D + R+ Sbjct: 183 AQYLSPEQARGDSVDARS-DVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPPSA 241 Query: 259 ----VSSECQHLIRWCLALRPSDR 278 +S++ ++ LA P +R Sbjct: 242 RHEGLSADLDAVVLKALAKNPENR 265 >3COM-A nrPDB Length = 314 Score = 67.8 bits (164), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 76/275 (27%), Positives = 119/275 (43%), Gaps = 30/275 (10%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 K+P E + V LG G +GSVY I VAIK V + SD E+ E+ Sbjct: 25 KQP-EEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVE--SDLQEIIK------EI 75 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFW 149 ++++ S V++ + + +++E + D I R L E+ + Sbjct: 76 SIMQQCDS--PHVVKYYGSYFKNTDLWIVMEYC-GAGSVSDIIRLRNKTLTEDEIATILQ 132 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY--TDFDGTRVY 207 L+ + + H +HRDIK NIL++ G KL DFG L DT+ GT + Sbjct: 133 STLKGLEYLHFMRKIHRDIKAGNILLN-TEGHAKLADFGVAGQLTDTMAKRNTVIGTPFW 191 Query: 208 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVF---------FRQR 258 PE I+ Y+ A +WSLGI +M G P+ D +R +F FR+ Sbjct: 192 MAPEVIQEIGYNC-VADIWSLGITAIEMAEGKPPYA-DIHPMRA-IFMIPTNPPPTFRKP 248 Query: 259 V--SSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 S ++ CL P R T ++ HP+++ Sbjct: 249 ELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVR 283 >2XYN-A nrPDB Length = 292 Score = 67.4 bits (163), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 65/259 (25%), Positives = 116/259 (44%), Gaps = 31/259 (11%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 LG G +G VY G+ +L VA+K +++D + E+ + E ++K++ + Sbjct: 40 LGGGQYGEVYVGVWKKYSLTVAVKTLKEDTM----EVEEFLK---EAAVMKEIKH--PNL 90 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITE--RGALQEELARSFFWQVLEAVRHCHNC 161 ++LL F ++ E P +L D++ E R + + Q+ A+ + Sbjct: 91 VQLLGVCTLEPPFYIVTEY-MPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 149 Query: 162 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---YSPPEWIRYHRY 218 +HRD+ N L+ N +K+ DFG L+ YT G + ++ PE + Y+ + Sbjct: 150 NFIHRDLAARNCLVGENH-VVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTF 208 Query: 219 HGRSAAVWSLGILLYDMVC-GDIPFEHDEEIIRGQVF------FRQRVSSEC----QHLI 267 +S VW+ G+LL+++ G P+ I QV+ +R C L+ Sbjct: 209 SIKS-DVWAFGVLLWEIATYGMSPYPG---IDLSQVYDLLEKGYRMEQPEGCPPKVYELM 264 Query: 268 RWCLALRPSDRPTFEEIQN 286 R C P+DRP+F E Sbjct: 265 RACWKWSPADRPSFAETHQ 283 >5J5T-A nrPDB Length = 370 Score = 67.4 bits (163), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 65/265 (24%), Positives = 111/265 (41%), Gaps = 31/265 (11%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 +GSG +G VY V+ AIK ++ + D+ V E++++K + Sbjct: 12 IGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFA------VVQQEIIMMKDCKH--PNI 63 Query: 104 IRLLDWFERPDSFVLILE--RPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNC 161 + + R D + +E +QD++ G L E + L+ + + H+ Sbjct: 64 VAYFGSYLRRDKLWICMEFCGGGSLQDIYHVT---GPLSELQIAYVSRETLQGLYYLHSK 120 Query: 162 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY--TDFDGTRVYSPPEWIRYHRYH 219 G +HRDIK NIL+ N G +KL DFG A + T+ F GT + PE R Sbjct: 121 GKMHRDIKGANILLTDN-GHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEVAAVERKG 179 Query: 220 GRS--AAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF------------RQRVSSECQH 265 G + +W++GI ++ P D +R + + S+ H Sbjct: 180 GYNQLCDLWAVGITAIELAELQPPM-FDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHH 238 Query: 266 LIRWCLALRPSDRPTFEEIQNHPWM 290 ++ L P RPT E++ HP++ Sbjct: 239 FVKMALTKNPKKRPTAEKLLQHPFV 263 >3A4O-X nrPDB Length = 286 Score = 67.4 bits (163), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 68/256 (26%), Positives = 118/256 (46%), Gaps = 26/256 (10%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 LG+G FG V+ G +++ VA+K ++ +S L E L+K + + Sbjct: 21 LGAGQFGEVWMGY-YNNSTKVAVKTLKPGTMSVQAFLE-------EANLMKTLQH--DKL 70 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFIT--ERGALQEELARSFFWQVLEAVRHCHNC 161 +RL R + +I E L DF+ E G + F Q+ E + + Sbjct: 71 VRLYAVVTREEPIYIITEYMAK-GSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERK 129 Query: 162 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---YSPPEWIRYHRY 218 +HRD++ N+L+ + K+ DFG +++D YT +G + ++ PE I + + Sbjct: 130 NYIHRDLRAANVLVSESL-MCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF 188 Query: 219 HGRSAAVWSLGILLYDMVC-GDIPF----EHDEEIIRGQVFFRQRVSS---ECQHLIRWC 270 +S VWS GILLY++V G IP+ D Q + RV + E +++ C Sbjct: 189 TIKSD-VWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMC 247 Query: 271 LALRPSDRPTFEEIQN 286 + +RPTF+ +Q+ Sbjct: 248 WKEKAEERPTFDYLQS 263 >3HKO-A nrPDB Length = 345 Score = 67.4 bits (163), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 64/256 (25%), Positives = 105/256 (41%), Gaps = 50/256 (19%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 L+ +Y + +G G +G V I AIK + K++I + R+ EV L+ Sbjct: 24 LQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQINP-KDVERIKTEVRLM 82 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERP------EPVQDLFDFITERGAL-------- 139 KK+ + RL + +E L++E + + D T + A+ Sbjct: 83 KKLHH--PNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMDVVKTQIC 140 Query: 140 -------------------------QEELARSFFWQVLEAVRHCHNCGVLHRDIKDENIL 174 +E+L + Q+ A+ + HN G+ HRDIK EN L Sbjct: 141 PCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRDIKPENFL 200 Query: 175 IDLNRG-ELKLIDFGSGA---LLKDTVY---TDFDGTRVYSPPEWIR-YHRYHGRSAAVW 226 N+ E+KL+DFG L + Y T GT + PE + + +G W Sbjct: 201 FSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESYGPKCDAW 260 Query: 227 SLGILLYDMVCGDIPF 242 S G+LL+ ++ G +PF Sbjct: 261 SAGVLLHLLLMGAVPF 276 >6AO5-A nrPDB Length = 362 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 72/277 (25%), Positives = 124/277 (44%), Gaps = 30/277 (10%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 K+P E + V LG G +GSV+ I VAIK V + SD E+ E+ Sbjct: 6 KQP-EEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE--SDLQEIIK------EI 56 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILER--PEPVQDLFDFITERGALQEELARSFF 148 ++++ S + V++ + + +++E V D+ + + +++E+A + Sbjct: 57 SIMQQCDSPY--VVKYYGSYFKNTDLWIVMEYCGAGSVSDIIR-LRNKTLIEDEIA-TIL 112 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY--TDFDGTRV 206 L+ + + H +HR+IK NIL++ G KL DFG L DT+ GT Sbjct: 113 KSTLKGLEYLHFMRKIHRNIKAGNILLN-TEGHAKLADFGVAGQLTDTMAKRNTVIGTPF 171 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVF--------FRQR 258 + PE I+ Y+ A +WSLGI +M G P+ D +R FR+ Sbjct: 172 WMAPEVIQEIGYNC-VADIWSLGITSIEMAEGKPPYA-DIHPMRAIFMIPTNPPPTFRKP 229 Query: 259 V--SSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 S + ++ CL P R T ++ HP++++ Sbjct: 230 ELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNA 266 >5O2B-A nrPDB Length = 285 Score = 67.4 bits (163), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 55/271 (20%), Positives = 114/271 (42%), Gaps = 38/271 (14%) Query: 44 LGSGGFGSVYSGIRVSDNLPVA--------IKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 LG G F +VY G+ + VA + E+ R + E+ G + P Sbjct: 24 LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQQRFKEEAEMLKGLQHP-------- 75 Query: 96 VSSGFSGVIRLLDWFE---RPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 ++R D +E + ++++ L ++ ++ ++ RS+ Q+L Sbjct: 76 ------NIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQIL 129 Query: 153 EAVRHCHNCG--VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPP 210 + ++ H ++HRD+K +NI I G +K+ D G L++ + GT + P Sbjct: 130 KGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAP 189 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF---EHDEEIIRGQV------FFRQRVSS 261 E Y ++ S V++ G+ + +M + P+ ++ +I R F + Sbjct: 190 EM--YEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDP 247 Query: 262 ECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 E + +I C+ S+R + ++ NH + + Sbjct: 248 EVKEIIEGCIRQNKSERLSIRDLLNHAFFAE 278 >3FME-A nrPDB Length = 290 Score = 67.0 bits (162), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 62/262 (23%), Positives = 114/262 (43%), Gaps = 23/262 (8%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV-VLLKKVSSGFSG 102 LG G +G V V +A+K RI R+ M++ + ++ V F+ Sbjct: 15 LGRGAYGVVEKMRHVPSGQIMAVK-----RIRATVNSQEQKRLLMDLDISMRTVDCPFT- 68 Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQVLEAVRHCHN- 160 V F D ++ + + + + ++G + E++ +++A+ H H+ Sbjct: 69 VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 128 Query: 161 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD-GTRVYSPPEWIR---YH 216 V+HRD+K N+LI+ G++K+ DFG L D V D D G + Y PE I Sbjct: 129 LSVIHRDVKPSNVLIN-ALGQVKMCDFGISGYLVDDVAKDIDAGCKPYMAPERINPELNQ 187 Query: 217 RYHGRSAAVWSLGILLYDMV-------CGDIPFEHDEEIIR--GQVFFRQRVSSECQHLI 267 + + + +WSLGI + ++ PF+ ++++ + S+E Sbjct: 188 KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFT 247 Query: 268 RWCLALRPSDRPTFEEIQNHPW 289 CL +RPT+ E+ HP+ Sbjct: 248 SQCLKKNSKERPTYPELMQHPF 269 >2HK5-A nrPDB Length = 270 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 51/171 (29%), Positives = 86/171 (50%), Gaps = 15/171 (8%) Query: 129 LFDFITERGALQEELAR--SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLID 186 L DF+ ++ L + F Q+ E + +HRD++ NIL+ + K+ D Sbjct: 96 LLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLV-CKIAD 154 Query: 187 FGSGALLKDTVYTDFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF 242 FG +++D YT +G + ++ PE I + + +S VWS GILL ++V G IP+ Sbjct: 155 FGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSD-VWSFGILLMEIVTYGRIPY 213 Query: 243 E--HDEEIIRG-QVFFR----QRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 + E+IR + +R + E +++ C RP +RPTFE IQ+ Sbjct: 214 PGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQS 264 >4XBR-A nrPDB Length = 366 Score = 67.0 bits (162), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 76/275 (27%), Positives = 131/275 (47%), Gaps = 27/275 (9%) Query: 27 PGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRV 86 PG + L++ ++G GS G + + +R S L VA+K ++ + L N Sbjct: 89 PGDPRSYLDNFIKIGE--GSTGIVCIAT-VRSSGKL-VAVKKMDLRKQQRRELLFN---- 140 Query: 87 PMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARS 146 EVV+++ V+ + + + D +++E E L D +T +E++A + Sbjct: 141 --EVVIMRDYQ--HENVVEMYNSYLVGDELWVVMEFLEG-GALTDIVTHTRMNEEQIA-A 194 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGT 204 VL+A+ H GV+HRDIK ++IL+ + G +KL DFG A + V GT Sbjct: 195 VCLAVLQALSVLHAQGVIHRDIKSDSILLT-HDGRVKLSDFGFCAQVSKEVPRRKSLVGT 253 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE-----EIIRGQVFFR--- 256 + PE I Y G +WSLGI++ +MV G+ P+ ++ ++IR + R Sbjct: 254 PYWMAPELISRLPY-GPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKN 312 Query: 257 -QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 +VS + + L P+ R T E+ HP++ Sbjct: 313 LHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFL 347 >4E93-A nrPDB Length = 377 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 66/258 (25%), Positives = 107/258 (41%), Gaps = 23/258 (8%) Query: 40 VGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 99 +G +G G FG V+SG +DN VA+K + D + E +LK+ S Sbjct: 118 LGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDL-----KAKFLQEARILKQYSH- 171 Query: 100 FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA-LQEELARSFFWQVLEAVRHC 158 ++RL+ + +++E + D F+ GA L+ + + + Sbjct: 172 -PNIVRLIGVCTQKQPIYIVMELVQG-GDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYL 229 Query: 159 HNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTR----VYSPPEWIR 214 + +HRD+ N L+ + LK+ DFG D VY G R ++ PE + Sbjct: 230 ESKCCIHRDLAARNCLVT-EKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALN 288 Query: 215 YHRYHGRSAAVWSLGILLYDMVC-GDIPF-----EHDEEIIR--GQVFFRQRVSSECQHL 266 Y RY S VWS GILL++ G P+ + E + G++ + L Sbjct: 289 YGRYSSES-DVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRL 347 Query: 267 IRWCLALRPSDRPTFEEI 284 + C A P RP+F I Sbjct: 348 MEQCWAYEPGQRPSFSTI 365 >4C59-A nrPDB Length = 340 Score = 66.6 bits (161), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 74/290 (25%), Positives = 121/290 (41%), Gaps = 43/290 (14%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 G+ E E + +V +L GGF VY V A+K + + E + Sbjct: 19 GQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSN------EEEKNRAII 72 Query: 88 MEVVLLKKVSSGFSGVIRLLDWF----ERPDS----FVLILERPE-PVQDLFDFITERGA 138 EV +KK+S G +++ E D+ F+L+ E + + + + RG Sbjct: 73 QEVCFMKKLS-GHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGP 131 Query: 139 LQEELARSFFWQVLEAVRHCHNCG--VLHRDIKDENILIDLNRGELKLIDFGSGALLKDT 196 L + F+Q AV+H H ++HRD+K EN+L+ N+G +KL DFGS + Sbjct: 132 LSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLS-NQGTIKLCDFGSATTISH- 189 Query: 197 VYTDF----------------DGTRVYSPPEWIRYHRYH--GRSAAVWSLGILLYDMVCG 238 Y D+ + T +Y PE I + G +W+LG +LY + Sbjct: 190 -YPDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFR 248 Query: 239 DIPFEHDEE--IIRGQVFF--RQRVSSECQHLIRWCLALRPSDRPTFEEI 284 PFE + I+ G+ + LIR L + P +R + E+ Sbjct: 249 QHPFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEV 298 >5KKR-C nrPDB Length = 395 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 33/80 (41%), Positives = 49/80 (61%), Gaps = 2/80 (2%) Query: 163 VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRS 222 ++HRD+K NIL++ +RGE+KL DFG L D++ F GTR Y PE ++ Y +S Sbjct: 188 IMHRDVKPSNILVN-SRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQS 246 Query: 223 AAVWSLGILLYDMVCGDIPF 242 +WS+G+ L +M G P Sbjct: 247 -DIWSMGLSLVEMAVGRYPI 265 >4MD7-E nrPDB Length = 391 Score = 66.2 bits (160), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 35/115 (30%), Positives = 61/115 (53%), Gaps = 1/115 (0%) Query: 131 DFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSG 190 DF L + R + +++L+A+ +CH+ G++HRD+K N++ID +L+LID+G Sbjct: 120 DFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179 Query: 191 ALLK-DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH 244 Y +R + PE + ++ + S +WSLG +L M+ PF H Sbjct: 180 EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 234 >3VN9-A nrPDB Length = 340 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 61/262 (23%), Positives = 114/262 (43%), Gaps = 23/262 (8%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV-VLLKKVSSGFSG 102 LG G +G V V +A+K RI R+ M++ + ++ V F+ Sbjct: 59 LGRGAYGVVEKMRHVPSGQIMAVK-----RIRATVNSQEQKRLLMDLDISMRTVDCPFT- 112 Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQVLEAVRHCHN- 160 V F D ++ + + + + ++G + E++ +++A+ H H+ Sbjct: 113 VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSK 172 Query: 161 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD-GTRVYSPPEWIR---YH 216 V+HRD+K N+LI+ G++K+ DFG L D+V D G + Y PE I Sbjct: 173 LSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQ 231 Query: 217 RYHGRSAAVWSLGILLYDMV-------CGDIPFEHDEEIIR--GQVFFRQRVSSECQHLI 267 + + + +WSLGI + ++ PF+ ++++ + S+E Sbjct: 232 KGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFT 291 Query: 268 RWCLALRPSDRPTFEEIQNHPW 289 CL +RPT+ E+ HP+ Sbjct: 292 SQCLKKNSKERPTYPELMQHPF 313 >2JD5-A nrPDB Length = 373 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 65/240 (27%), Positives = 114/240 (47%), Gaps = 29/240 (12%) Query: 27 PGKEKEPL-ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTR 85 P + EP +++Y + LG G F +V+ + +N VA+K V D++ Sbjct: 9 PAFKGEPYKDARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYT-------EA 61 Query: 86 VPMEVVLLKKV---------SSGFSGVIRLLDWFER--PDSFVLILERPEPVQDLFDFIT 134 E+ LL++V S G + +++LLD F P+ +++ ++L I Sbjct: 62 AEDEIKLLQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIK 121 Query: 135 --ERGALQEELARSFFWQVLEAVRHCHN-CGVLHRDIKDENILIDL-----NRGELKLID 186 E + + Q+L + + H CG++H DIK EN+L+++ N ++K+ D Sbjct: 122 KYEHRGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIAD 181 Query: 187 FGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE 246 G+ A D YT+ TR Y PE + + G A +WS L+++++ GD FE DE Sbjct: 182 LGN-ACWYDEHYTNSIQTREYRSPEVLLGAPW-GCGADIWSTACLIFELITGDFLFEPDE 239 >2I6L-A nrPDB Length = 320 Score = 65.9 bits (159), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 79/320 (24%), Positives = 133/320 (41%), Gaps = 66/320 (20%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 L S+Y LG GG G V+S + + VAIK + ++D + + R E+ ++ Sbjct: 9 LGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI---VLTDPQSVKHALR---EIKII 62 Query: 94 KKVSS----------GFSGVIRLLD---WFERPDSFVLILERPEPVQDLFDFITERGALQ 140 +++ G SG +L D +S ++ E E DL + + E+G L Sbjct: 63 RRLDHDNIVKVFEILGPSGS-QLTDDVGSLTELNSVYIVQEYME--TDLAN-VLEQGPLL 118 Query: 141 EELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTD 200 EE AR F +Q+L +++ H+ VLHRD+K N+ I+ LK+ DFG ++ D Y+ Sbjct: 119 EEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIM-DPHYSH 177 Query: 201 ----FDG--TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVF 254 +G T+ Y P + + ++ +W+ G + +M+ G F E+ + Q+ Sbjct: 178 KGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLI 237 Query: 255 F----------RQR--------------------------VSSECQHLIRWCLALRPSDR 278 RQ +S E + L P DR Sbjct: 238 LESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPMDR 297 Query: 279 PTFEEIQNHPWMQDVLLPQE 298 T EE +HP+M P + Sbjct: 298 LTAEEALSHPYMSIYSFPMD 317 >6EII-A nrPDB Length = 352 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 53/213 (24%), Positives = 98/213 (46%), Gaps = 17/213 (7%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 + YQ+ LG G + V+ I +++N + + + ++ E+ +L+ Sbjct: 59 QDDYQLVRKLGRGKYSEVFEAINITNN---------EKVVVKILKPVKKKKIKREIKILE 109 Query: 95 KVSSGFSGVIRLLDWFERPDSFV--LILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 + G +I L D + P S L+ E DF L + R + +++L Sbjct: 110 NLRGG-PNIITLADIVKDPVSRTPALVFEHVNNT----DFKQLYQTLTDYDIRFYMYEIL 164 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRVYSPPE 211 +A+ +CH+ G++HRD+K N++ID +L+LID+G Y +R + PE Sbjct: 165 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 224 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH 244 + ++ + S +WSLG +L M+ PF H Sbjct: 225 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFH 257 >2OU7-A nrPDB Length = 335 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 68/266 (25%), Positives = 109/266 (40%), Gaps = 24/266 (9%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 LG GGF + A K V K + L R M + + S Sbjct: 48 FLGKGGFAKCFEISDADTKEVFAGKIVPKSLL-----LKPHQREKMSMEISIHRSLAHQH 102 Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCG 162 V+ +FE D ++LE + L + R AL E AR + Q++ ++ H Sbjct: 103 VVGFHGFFEDNDFVFVVLELCR-RRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNR 161 Query: 163 VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD------GTRVYSPPEWIRYH 216 V+HRD+K N+ ++ + E+K+ DFG L V D + GT Y PE + Sbjct: 162 VIHRDLKLGNLFLNEDL-EVKIGDFG----LATKVEYDGERKKVLCGTPNYIAPEVLS-K 215 Query: 217 RYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRWC 270 + H VWS+G ++Y ++ G PFE I + + + ++ LI+ Sbjct: 216 KGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKM 275 Query: 271 LALRPSDRPTFEEIQNHPWMQDVLLP 296 L P+ RPT E+ N + +P Sbjct: 276 LQTDPTARPTINELLNDEFFTSGYIP 301 >2DQ7-X nrPDB Length = 283 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 75/260 (28%), Positives = 117/260 (45%), Gaps = 35/260 (13%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 LG+G FG V+ G + N VAIK ++ +S L E ++KK+ + Sbjct: 17 LGNGQFGEVWMGTW-NGNTKVAIKTLKPGTMSPESFLE-------EAQIMKKLKH--DKL 66 Query: 104 IRLLDWF-ERPDSFVLILERPEPVQDLFDFIT--ERGALQEELARSFFWQVLEAVRHCHN 160 ++L E P + I+ L DF+ E AL+ QV + + Sbjct: 67 VQLYAVVSEEP---IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER 123 Query: 161 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---YSPPEWIRYHR 217 +HRD++ NIL+ N K+ DFG L++D YT G + ++ PE Y R Sbjct: 124 MNYIHRDLRSANILVG-NGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGR 182 Query: 218 YHGRSAAVWSLGILLYDMVC-GDIPF------EHDEEIIRGQVFFRQRVSSEC----QHL 266 + +S VWS GILL ++V G +P+ E E++ RG +R +C L Sbjct: 183 FTIKS-DVWSFGILLTELVTKGRVPYPGMNNREVLEQVERG---YRMPCPQDCPISLHEL 238 Query: 267 IRWCLALRPSDRPTFEEIQN 286 + C P +RPTFE +Q+ Sbjct: 239 MIHCWKKDPEERPTFEYLQS 258 >3EQC-A nrPDB Length = 360 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 33/80 (41%), Positives = 49/80 (61%), Gaps = 2/80 (2%) Query: 163 VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRS 222 ++HRD+K NIL++ +RGE+KL DFG L D++ F GTR Y PE ++ Y +S Sbjct: 153 IMHRDVKPSNILVN-SRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQS 211 Query: 223 AAVWSLGILLYDMVCGDIPF 242 +WS+G+ L +M G P Sbjct: 212 -DIWSMGLSLVEMAVGRYPI 230 >4M7I-A nrPDB Length = 299 Score = 65.5 bits (158), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 77/299 (25%), Positives = 131/299 (43%), Gaps = 60/299 (20%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT----RVPMEVVLLKKVSSG 99 LG GGFG V+ D+ AIK + LPN +V EV L K+ Sbjct: 13 LGRGGFGVVFEAKNKVDDCNYAIKRIR---------LPNRELAREKVMREVKALAKLEH- 62 Query: 100 FSGVIRLLD-WFER----------PDSFVLILERPEPVQDLFDFITERGALQEE---LAR 145 G++R + W E+ P ++ I + ++L D++ R ++E + Sbjct: 63 -PGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCL 121 Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKD----TVYTD 200 F Q+ EAV H+ G++HRD+K NI ++ +K+ DFG A+ +D TV T Sbjct: 122 HIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMD-DVVKVGDFGLVTAMDQDEEEQTVLTP 180 Query: 201 FD---------GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRG 251 GT++Y PE I + Y ++SLG++L++++ PF E +R Sbjct: 181 MPAYARHTGQVGTKLYMSPEQIHGNSY-SHKVDIFSLGLILFELL---YPFSTQMERVRT 236 Query: 252 QV---------FFRQRVSSECQH-LIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA 300 F Q+ C++ +++ L+ P +RP I + +D+ P +T Sbjct: 237 LTDVRNLKFPPLFTQKYP--CEYVMVQDMLSPSPMERPEAINIIENAVFEDLDFPGKTV 293 >2XS0-A nrPDB Length = 386 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 69/280 (24%), Positives = 119/280 (42%), Gaps = 35/280 (12%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +YQ +GSG G V + VAIK + + + + R E+VL+K Sbjct: 26 KRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP----FQNQTHAKRAYRELVLMKC 81 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA---------LQEELARS 146 V+ +I LL+ F S E QD++ + A L E Sbjct: 82 VNH--KNIIGLLNVFTPQKSL-------EEFQDVYIVMELMDANLCQVIQMELDHERMSY 132 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-VYTDFDGTR 205 +Q+L ++H H+ G++HRD+K NI++ + LK++DFG + + F TR Sbjct: 133 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLARTAGTSFMMVPFVVTR 191 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQH 265 Y PE I Y + +WS+G ++ +M+ G + F + I + Q + + C Sbjct: 192 YYRAPEVILGMGYK-ENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ-LGTPCPE 249 Query: 266 LIRWCLALRPS------DRPTFEEIQNHPWMQDVLLPQET 299 ++ L+P+ +RP + DVL P ++ Sbjct: 250 FMK---KLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADS 286 >5Y86-A nrPDB Length = 588 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 62/224 (27%), Positives = 103/224 (45%), Gaps = 24/224 (10%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDN---LPVAIKHVEKDRISDWGELPNGTRVPMEV 90 L +Y+V ++G G FG V RV D+ VA+K V ++ + E+ Sbjct: 205 LAYRYEVLKIIGKGSFGQV---ARVYDHKLRQYVALKMVRNEKRFH-------RQAAEEI 254 Query: 91 VLL----KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELA 144 +L K+ +G VI +L+ F + + E DL++ I + +L Sbjct: 255 RILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS--IDLYELIKKNKFQGFSVQLV 312 Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLN-RGELKLIDFGSGALLKDTVYTDFDG 203 R F +L+++ H ++H D+K ENIL+ + R K+IDFGS +YT + Sbjct: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-YIQ 371 Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE 247 +R Y PE I RY +WS G +L +++ G F ++E Sbjct: 372 SRFYRAPEIILGSRY-STPIDIWSFGCILAELLTGQPLFPGEDE 414 >4J52-A nrPDB Length = 293 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 68/266 (25%), Positives = 109/266 (40%), Gaps = 24/266 (9%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 LG GGF + A K V K + L R M + + S Sbjct: 21 FLGKGGFAKCFEISDADTKEVFAGKIVPKSLL-----LKPHQREKMSMEISIHRSLAHQH 75 Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCG 162 V+ +FE D ++LE + L + R AL E AR + Q++ ++ H Sbjct: 76 VVGFHGFFEDNDFVFVVLELCRR-RSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNR 134 Query: 163 VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD------GTRVYSPPEWIRYH 216 V+HRD+K N+ ++ + E+K+ DFG L V D + GT Y PE + Sbjct: 135 VIHRDLKLGNLFLNEDL-EVKIGDFG----LATKVEYDGERKKVLCGTPNYIAPEVLS-K 188 Query: 217 RYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRWC 270 + H VWS+G ++Y ++ G PFE I + + + ++ LI+ Sbjct: 189 KGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKM 248 Query: 271 LALRPSDRPTFEEIQNHPWMQDVLLP 296 L P+ RPT E+ N + +P Sbjct: 249 LQTDPTARPTINELLNDEFFTSGYIP 274 >4UY9-A nrPDB Length = 323 Score = 65.1 bits (157), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 63/262 (24%), Positives = 111/262 (42%), Gaps = 31/262 (11%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 ++G GGFG VY + D VA+K D D + R ++ + K Sbjct: 16 IIGIGGFGKVYRAFWIGDE--VAVKAARHDPDEDISQTIENVRQEAKLFAMLK----HPN 69 Query: 103 VIRLLDWFERPDSFVLILE--RPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHN 160 +I L + + L++E R P+ + + + ++ ++ Q+ + + H+ Sbjct: 70 IIALRGVCLKEPNLCLVMEFARGGPL----NRVLSGKRIPPDILVNWAVQIARGMNYLHD 125 Query: 161 ---CGVLHRDIKDENILI-------DLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPP 210 ++HRD+K NILI DL+ LK+ DFG T GT + P Sbjct: 126 EAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYAWMAP 185 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVS----SEC--- 263 E IR + + + VWS G+LL++++ G++PF + + +++ S C Sbjct: 186 EVIRASMF-SKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEP 244 Query: 264 -QHLIRWCLALRPSDRPTFEEI 284 L+ C P RP+F I Sbjct: 245 FAKLMEDCWNPDPHSRPSFTNI 266 >3LM0-A nrPDB Length = 327 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 74/284 (26%), Positives = 123/284 (43%), Gaps = 41/284 (14%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDR---------ISDWGELPNGTRVPMEVVLLK 94 LG G F V I S A K ++K R + + L P V+ L Sbjct: 37 LGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCP-RVINLH 95 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 +V S +I +L++ + F L L PE L + ++E ++ Q+LE Sbjct: 96 EVYENTSEIILILEYAAGGEIFSLCL--PE----LAEMVSENDVIR------LIKQILEG 143 Query: 155 VRHCHNCGVLHRDIKDENILID--LNRGELKLIDFG-SGALLKDTVYTDFDGTRVYSPPE 211 V + H ++H D+K +NIL+ G++K++DFG S + + GT Y PE Sbjct: 144 VYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPE 203 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHDEE----IIRGQVFFRQRVSSECQH 265 + Y + +W++GI+ Y ++ PF E ++E I + V + + S Sbjct: 204 ILNYDPI-TTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQ 262 Query: 266 L----IRWCLALRPSDRPTFEEIQNHPWMQ-----DVLLPQETA 300 L I+ L P RPT E +H W+Q ++ P+ET+ Sbjct: 263 LATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETS 306 >4FZF-B nrPDB Length = 283 Score = 64.7 bits (156), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 66/257 (25%), Positives = 110/257 (42%), Gaps = 22/257 (8%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 +G G FG V+ GI VAIK ++ + D + E+ +L + S + V Sbjct: 16 IGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAED-----EIEDIQQEITVLSQCDSSY--V 68 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGV 163 + + + +I+E L D + G E + ++L+ + + H+ Sbjct: 69 TKYYGSYLKGSKLWIIMEYLGGGSAL-DLL-RAGPFDEFQIATMLKEILKGLDYLHSEKK 126 Query: 164 LHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY--TDFDGTRVYSPPEWIRYHRYHGR 221 +HRDIK N+L+ +G++KL FG L DT F GT + PE I+ Y + Sbjct: 127 IHRDIKAANVLLS-EQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDSK 185 Query: 222 SAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR--------VSSECQHLIRWCLAL 273 A +WSLGI ++ G+ P D +R + + + I CL Sbjct: 186 -ADIWSLGITAIELAKGEPP-NSDMHPMRVLFLIPKNNPPTLVGDFTKSFKEFIDACLNK 243 Query: 274 RPSDRPTFEEIQNHPWM 290 PS RPT +E+ H ++ Sbjct: 244 DPSFRPTAKELLKHKFI 260 >2PMN-X nrPDB Length = 348 Score = 64.3 bits (155), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 71/324 (21%), Positives = 124/324 (38%), Gaps = 77/324 (23%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEK--------------DRI 74 KEK+ + Y++ L G F + + DN A+K EK D+I Sbjct: 24 KEKDKYINDYRIIRTLNQGKFNKII--LCEKDNKFYALKKYEKSLLEKKRDFTKSNNDKI 81 Query: 75 S---DWGELPNGTRVPMEV-----VLLKKVSSGFSGVIRLLDWFE-----RPDSFVLILE 121 S + + N ++ ++ + + + + + V + ++ E + D + +L+ Sbjct: 82 SIKSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFFVLD 141 Query: 122 RPE----PVQDLFDFITERGALQEELARSFFWQVLEAVRHCHN-CGVLHRDIKDENILID 176 + P+Q + + VL + + HN + HRD+K NIL+D Sbjct: 142 KNYTCFIPIQ---------------VIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMD 186 Query: 177 LNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHR-YHGRSAAVWSLGILLYDM 235 N G +KL DFG + D GT + PPE+ Y+G +WSLGI LY M Sbjct: 187 KN-GRVKLSDFGESEYMVDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVM 245 Query: 236 VCGDIPFEHDEEII----------------RGQVFF----------RQRVSSECQHLIRW 269 +PF ++ R + +S+E ++ Sbjct: 246 FYNVVPFSLKISLVELFNNIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKL 305 Query: 270 CLALRPSDRPTFEEIQNHPWMQDV 293 L P++R T E+ H W+ D Sbjct: 306 FLRKNPAERITSEDALKHEWLADT 329 >5NGU-A nrPDB Length = 381 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 55/220 (25%), Positives = 98/220 (44%), Gaps = 33/220 (15%) Query: 38 YQVGP------LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVV 91 + VGP +G G +G V S + + VAIK +IS + R E+ Sbjct: 38 FDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIK-----KISPFEHQTYCQRTLREIK 92 Query: 92 LLKKVSS----GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARS- 146 +L + G + +IR + D ++ VQDL + + + L+ Sbjct: 93 ILLRFRHENIIGINDIIRAPTIEQMKDVYI--------VQDLMETDLYKLLKTQHLSNDH 144 Query: 147 ---FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-----DTVY 198 F +Q+L +++ H+ VLHRD+K N+L++ +LK+ DFG + Sbjct: 145 ICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGLARVADPDHDHTGFL 203 Query: 199 TDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCG 238 T++ TR Y PE + + + +S +WS+G +L +M+ Sbjct: 204 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN 243 >1S9I-A nrPDB Length = 354 Score = 63.9 bits (154), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 32/80 (40%), Positives = 49/80 (61%), Gaps = 2/80 (2%) Query: 163 VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRS 222 ++HRD+K NIL++ +RGE+KL DFG L D++ F GTR Y PE ++ Y +S Sbjct: 136 IMHRDVKPSNILVN-SRGEIKLCDFGVSGQLIDSMANSFVGTRSYMAPERLQGTHYSVQS 194 Query: 223 AAVWSLGILLYDMVCGDIPF 242 +WS+G+ L ++ G P Sbjct: 195 -DIWSMGLSLVELAVGRYPI 213 >3SV0-A nrPDB Length = 483 Score = 63.9 bits (154), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 71/282 (25%), Positives = 129/282 (45%), Gaps = 50/282 (17%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPN-GTRVPMEVVLLK 94 +++++G +GSG FG +Y G + N VAIK L N T+ P + K Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIK------------LENVKTKHPQLLYESK 54 Query: 95 --KVSSGFSGVIRLLDWFE-RPDSFVLILERPEP-VQDLFDFITERGALQEELARSFFWQ 150 ++ G +G+ + WF D VL+++ P ++DLF+F + + +L+ L Q Sbjct: 55 IYRILQGGTGIPN-VRWFGVEGDYNVLVMDLLGPSLEDLFNFCSRKLSLKTVLM--LADQ 111 Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNR--GELKLIDFGSGALLKDTVY---------T 199 ++ V H+ LHRDIK +N L+ L R ++ +IDFG +DT Sbjct: 112 MINRVEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENK 171 Query: 200 DFDGTRVYSPPEWIRYHR--YHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR- 256 + GT Y+ + H R + SLG +L + G +P++ + + Q + + Sbjct: 172 NLTGTARYAS---VNTHLGIEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKI 228 Query: 257 --QRVSSECQHLIR-----------WCLALRPSDRPTFEEIQ 285 ++V++ + L R +C +LR D+P + ++ Sbjct: 229 SEKKVATSIEALCRGYPTEFASYFHYCRSLRFDDKPDYSYLK 270 >4U41-A nrPDB Length = 332 Score = 63.9 bits (154), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 74/278 (26%), Positives = 117/278 (42%), Gaps = 34/278 (12%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 +++ ++G+G +G VY G V AIK ++ + + +E+ +LKK S Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE-------EEIKLEINMLKKYS 78 Query: 98 -----SGFSGVIRLLDWFERPDSFVLILE--RPEPVQDLFDFITERGALQEELARSFFWQ 150 + + G D L++E + DL T+ L+E+ + Sbjct: 79 HHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKN-TKGNTLKEDWIAYISRE 137 Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYS 208 +L + H H V+HRDIK +N+L+ N E+KL+DFG A L TV F GT + Sbjct: 138 ILRGLAHLHIHHVIHRDIKGQNVLLTEN-AEVKLVDFGVSAQLDRTVGRRNTFIGTPYWM 196 Query: 209 PPEWIRYHR-----YHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR----- 258 PE I Y RS +WS GI +M G P D +R + Sbjct: 197 APEVIACDENPDATYDYRS-DLWSCGITAIEMAEGAPPL-CDMHPMRALFLIPRNPPPRL 254 Query: 259 ----VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 S + I CL RP+ E++ HP+++D Sbjct: 255 KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRD 292 >4AW2-A nrPDB Length = 437 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 42/111 (37%), Positives = 65/111 (58%), Gaps = 8/111 (7%) Query: 139 LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSG-ALLKD-T 196 L EE+AR + +++ A+ H +HRDIK +NIL+D+N G ++L DFGS L++D T Sbjct: 172 LPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMN-GHIRLADFGSCLKLMEDGT 230 Query: 197 VYTDFD-GTRVYSPPEWIRYHR----YHGRSAAVWSLGILLYDMVCGDIPF 242 V + GT Y PE ++ +G WSLG+ +Y+M+ G+ PF Sbjct: 231 VQSSVAVGTPDYISPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPF 281 >3DTC-A nrPDB Length = 271 Score = 63.5 bits (153), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 62/265 (23%), Positives = 110/265 (41%), Gaps = 31/265 (11%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 ++G GGFG VY + D VA+K D D + R ++ + K Sbjct: 14 IIGIGGFGKVYRAFWIGDE--VAVKAARHDPDEDISQTIENVRQEAKLFAMLK----HPN 67 Query: 103 VIRLLDWFERPDSFVLILE--RPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHN 160 +I L + + L++E R P+ + + ++ ++ Q+ + + H+ Sbjct: 68 IIALRGVCLKEPNLCLVMEFARGGPLNRVL----SGKRIPPDILVNWAVQIARGMNYLHD 123 Query: 161 ---CGVLHRDIKDENILI-------DLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPP 210 ++HRD+K NILI DL+ LK+ DFG T G + P Sbjct: 124 EAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYAWMAP 183 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVS----SEC--- 263 E IR + + + VWS G+LL++++ G++PF + + +++ S C Sbjct: 184 EVIRASMF-SKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPSTCPEP 242 Query: 264 -QHLIRWCLALRPSDRPTFEEIQNH 287 L+ C P RP+F I + Sbjct: 243 FAKLMEDCWNPDPHSRPSFTNILDQ 267 >5TE0-A nrPDB Length = 347 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 83/308 (26%), Positives = 130/308 (42%), Gaps = 51/308 (16%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 Q V +L GGF V+ +R S+ + A+K + + D +V + + + Sbjct: 20 QVTVDEVLAEGGFAIVFL-VRTSNGMKCALKRMFVNNEHDL-------QVCKREIQIMRD 71 Query: 97 SSGFSGVIRLLDWFERPDSF-----VLILE---RPEPVQDLFDFITERGALQEELARSFF 148 SG ++ +D S VLIL R V +L + + G + E+ + F Sbjct: 72 LSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQ-IF 130 Query: 149 WQVLEAVRHCHNCG--VLHRDIKDENILIDLNRGELKLIDFGSGA------------LLK 194 EAV H C ++HRD+K ENIL+ +RG L DFGS ++ Sbjct: 131 CDTCEAVARLHQCKTPIIHRDLKVENILLH-DRGHYVLCDFGSATNKFQNPQTEGVNAVE 189 Query: 195 DTV--YTDFDGTRVYSPPEWIRYHRYHGR----SAAVWSLGILLYDMVCGDIPFEHDEEI 248 D + YT T Y PE + + Y G+ A +W+LG LLY + +PF + Sbjct: 190 DEIKKYT----TLSYRAPEMV--NLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVA 243 Query: 249 IRGQVFF---RQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLH 305 I F R S + LIR+ L P RP ++ + LL +E ++ Sbjct: 244 ICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVS---YFSFKLLKKECPIPNVQ 300 Query: 306 SLSPGPSK 313 + SP P+K Sbjct: 301 N-SPIPAK 307 >5B2L-A nrPDB Length = 324 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 53/165 (32%), Positives = 78/165 (47%), Gaps = 30/165 (18%) Query: 162 GVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWI-----RY 215 GV+HRD+K NIL+D RG++KL DFG SG L+ T G Y PE I Sbjct: 137 GVIHRDVKPSNILLD-ERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTK 195 Query: 216 HRYHGRSAAVWSLGILLYDMVCGDIPFEH---DEEIIR-----------GQVFFRQRVSS 261 Y R A VWSLGI L ++ G P+++ D E++ G + F S Sbjct: 196 PDYDIR-ADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGF----SG 250 Query: 262 ECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHS 306 + Q ++ CL RP + ++ H +++ ET E+ + S Sbjct: 251 DFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRY----ETLEVDVAS 291 >4Y93-A nrPDB Length = 446 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 66/251 (26%), Positives = 118/251 (47%), Gaps = 25/251 (9%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 LG+G FG V G + VAIK +++ +S+ E +V M + K V GV Sbjct: 196 LGTGQFGVVKYG-KWRGQYDVAIKMIKEGSMSE-DEFIEEAKVMMNLSHEKLVQ--LYGV 251 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSFFWQVLEAVRHCHNCG 162 +RP + I+ L +++ E R Q + V EA+ + + Sbjct: 252 CTK----QRP---IFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQ 304 Query: 163 VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---YSPPEWIRYHRYH 219 LHRD+ N L++ ++G +K+ DFG + D YT G++ ++ PE + Y ++ Sbjct: 305 FLHRDLAARNCLVN-DQGVVKVSDFGMTRYVLDDEYTSSTGSKFPVKWASPEVLMYSKFS 363 Query: 220 GRSAAVWSLGILLYDMVC-GDIPFEH------DEEIIRGQVFFRQRVSSECQHLIRW-CL 271 +S +W+ G+L++++ G +P+E E I +G R ++SE + I + C Sbjct: 364 SKS-DIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLPRPHLASERVYAIMYSCW 422 Query: 272 ALRPSDRPTFE 282 + +RPTF+ Sbjct: 423 HEKADERPTFK 433 >3OZ6-A nrPDB Length = 388 Score = 63.2 bits (152), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 54/232 (23%), Positives = 107/232 (46%), Gaps = 44/232 (18%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +Y++ LG G +G V+ I VA+K + + + R E+++L ++ Sbjct: 10 KYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKI----FDAFQNSTDAQRTFREIMILTEL 65 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE------RGALQEELARSFF-W 149 S G ++ LL+ VL + V +FD++ R + E + + + + Sbjct: 66 S-GHENIVNLLN--------VLRADNDRDVYLVFDYMETDLHAVIRANILEPVHKQYVVY 116 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSG---------------ALLK 194 Q+++ +++ H+ G+LHRD+K NIL++ +K+ DFG ++ + Sbjct: 117 QLIKVIKYLHSGGLLHRDMKPSNILLNA-ECHVKVADFGLSRSFVNIRRVTNNIPLSINE 175 Query: 195 DT--------VYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCG 238 +T + TD+ TR Y PE + + + +WSLG +L +++CG Sbjct: 176 NTENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCG 227 >5ZTN-A nrPDB Length = 429 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 56/205 (27%), Positives = 91/205 (44%), Gaps = 10/205 (4%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +Y+V ++G G FG V + VA+K V ++ + + L K+ Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRF---HRQAAEEIRILEHLRKQD 154 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLEA 154 VI +L+ F + + E +L++ I + L R F +L+ Sbjct: 155 KDNTMNVIHMLENFTFRNHICMTFELLS--MNLYELIKKNKFQGFSLPLVRKFAHSILQC 212 Query: 155 VRHCHNCGVLHRDIKDENILI-DLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWI 213 + H ++H D+K ENIL+ R +K+IDFGS VYT + +R Y PE I Sbjct: 213 LDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYT-YIQSRFYRAPEVI 271 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCG 238 RY G +WSLG +L +++ G Sbjct: 272 LGARY-GMPIDMWSLGCILAELLTG 295 >5VO2-A nrPDB Length = 300 Score = 62.4 bits (150), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 50/158 (31%), Positives = 80/158 (50%), Gaps = 14/158 (8%) Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPEW 212 + + H ++HRD+K N+LI + +K+ DFG+ L D + F GT + PE Sbjct: 112 GMNYLHLHKIIHRDLKSPNMLITYD-DVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEV 170 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH-DEEII---RGQVFFRQRVSSEC----Q 264 IR + +WS G++L++++ G+IP++ D I G V S C + Sbjct: 171 IRNEPVSEK-VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFK 229 Query: 265 HLIRWCLALRPSDRPTFEEIQNHPWM--QDVL-LPQET 299 L+R C +P +RP+F +I H + DVL PQET Sbjct: 230 ILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQET 267 >3TKU-A nrPDB Length = 433 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 39/111 (35%), Positives = 63/111 (56%), Gaps = 8/111 (7%) Query: 139 LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD--T 196 L E++AR + +++ A+ H +HRDIK +N+L+D+N G ++L DFGS + D T Sbjct: 188 LPEDMARFYIGEMVLAIDSIHQLHYVHRDIKPDNVLLDVN-GHIRLADFGSCLKMNDDGT 246 Query: 197 VYTDFD-GTRVYSPPEWIRYHR----YHGRSAAVWSLGILLYDMVCGDIPF 242 V + GT Y PE ++ +G WSLG+ +Y+M+ G+ PF Sbjct: 247 VQSSVAVGTPDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPF 297 >2UV2-A nrPDB Length = 325 Score = 62.4 bits (150), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 70/267 (26%), Positives = 116/267 (43%), Gaps = 34/267 (12%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVE---KDRISDWGELPNGTRVPMEVVLLKKVSSGF 100 LG G FG VY ++ A K ++ ++ + D+ +E+ +L S Sbjct: 45 LGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDYM---------VEIDIL--ASCDH 93 Query: 101 SGVIRLLDWFERPDSFVLILER-PEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 159 +++LLD F ++ +++E D ER L E + Q L+A+ + H Sbjct: 94 PNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELER-PLTESQIQVVCKQTLDALNYLH 152 Query: 160 NCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY--TDFDGTRVYSPPEWIRYHR 217 + ++HRD+K NIL L+ G++KL DFG A T+ F GT + PE + Sbjct: 153 DNKIIHRDLKAGNILFTLD-GDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEVVMCET 211 Query: 218 YHGR----SAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ----------RVSSEC 263 R A VWSLGI L +M + P H+ +R + + R SS Sbjct: 212 SKDRPYDYKADVWSLGITLIEMAEIEPP-HHELNPMRVLLKIAKSEPPTLAQPSRWSSNF 270 Query: 264 QHLIRWCLALRPSDRPTFEEIQNHPWM 290 + ++ CL R T ++ HP++ Sbjct: 271 KDFLKKCLEKNVDARWTTSQLLQHPFV 297 >6FYV-A nrPDB Length = 337 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 61/238 (25%), Positives = 103/238 (43%), Gaps = 33/238 (13%) Query: 34 LESQYQVGPLLGSGGFGSVYSGI-RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVV- 91 L ++Y++ LG G FG V I D + VA+K V+ + G R ++V+ Sbjct: 12 LRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVK-----NVGRYREAARSEIQVLE 66 Query: 92 -LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGAL--QEELARSFF 148 L + +++L+WF+ ++ E +DFI E L Q + R Sbjct: 67 HLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGL--STYDFIKENSFLPFQIDHIRQMA 124 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILI------------------DLNRGELKLIDFGSG 190 +Q+ +++ H+ + H D+K ENIL L ++K++DFGS Sbjct: 125 YQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGS- 183 Query: 191 ALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE-HDEE 247 A D ++ TR Y PE I + + VWS+G +L + G F+ HD + Sbjct: 184 ATYDDEHHSTLVSTRHYRAPEVILALGW-SQPCDVWSIGCILIEYYLGFTVFQTHDSK 240 >4QTB-A nrPDB Length = 380 Score = 62.0 bits (149), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 60/233 (25%), Positives = 102/233 (43%), Gaps = 35/233 (15%) Query: 26 APGKEKEPLESQ-YQVGP------LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWG 78 PG E E ++ Q + VGP +G G +G V S VAIK +IS + Sbjct: 25 VPG-EVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIK-----KISPFE 78 Query: 79 ELPNGTRVPMEVVLLKKVSS----GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT 134 R E+ +L + G ++R D ++ VQDL + Sbjct: 79 HQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYI--------VQDLMETDL 130 Query: 135 ERGALQEELARS----FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSG 190 + ++L+ F +Q+L +++ H+ VLHRD+K N+LI+ +LK+ DFG Sbjct: 131 YKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLIN-TTCDLKICDFGLA 189 Query: 191 ALLK-----DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCG 238 + T++ TR Y PE + + + +S +WS+G +L +M+ Sbjct: 190 RIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSN 242 >3C51-A nrPDB Length = 543 Score = 62.0 bits (149), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 77/313 (24%), Positives = 132/313 (42%), Gaps = 36/313 (11%) Query: 9 LAHLRAAP----CNDLHATKLAPGK--EKEPL-ESQYQVGPLLGSGGFGSVYS-GIRVSD 60 LAHL AP + L+ + K E +P+ E + +LG GGFG V++ ++ + Sbjct: 151 LAHLGQAPFQEFLDSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGRGGFGEVFACQMKATG 210 Query: 61 NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVL-- 118 L K +K G G V E +L KV S F ++ L FE L Sbjct: 211 KLYACKKLNKKRLKKRKGY--QGAMV--EKKILAKVHSRF--IVSLAYAFETKTDLCLVM 264 Query: 119 -ILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDL 177 I+ + +++ + QE A + Q++ + H H +++RD+K EN+L+D Sbjct: 265 TIMNGGDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLD- 323 Query: 178 NRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDM 235 + G +++ D G LK T + GT + PE + Y S ++LG+ LY+M Sbjct: 324 DDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEYD-FSVDYFALGVTLYEM 382 Query: 236 VCGDIPF----------EHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEE-- 283 + PF E + ++ V + + S + L P R F + Sbjct: 383 IAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQKDPEKRLGFRDGS 442 Query: 284 ---IQNHPWMQDV 293 ++ HP +D+ Sbjct: 443 CDGLRTHPLFRDI 455 >3LMG-A nrPDB Length = 344 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 65/272 (23%), Positives = 132/272 (48%), Gaps = 34/272 (12%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRV----SDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 E++ + +LGSG FG+V+ G+ + S +PV IK +E R + Sbjct: 30 ETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIED----------KSGRQSFQA 79 Query: 91 V---LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARS 146 V +L S + ++RLL P S + ++ + P+ L D + + RGAL +L + Sbjct: 80 VTDHMLAIGSLDHAHIVRLLGLC--PGSSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLN 137 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL----KDTVYTDFD 202 + Q+ + + + G++HR++ N+L+ + ++++ DFG LL K +Y++ Sbjct: 138 WGVQIAKGMYYLEEHGMVHRNLAARNVLLK-SPSQVQVADFGVADLLPPDDKQLLYSEAK 196 Query: 203 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYD-MVCGDIPF------EHDEEIIRGQVFF 255 + E I + +Y +S VWS G+ +++ M G P+ E + + +G+ Sbjct: 197 TPIKWMALESIHFGKYTHQS-DVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLA 255 Query: 256 RQRVSS-ECQHLIRWCLALRPSDRPTFEEIQN 286 + ++ + + ++ C + + RPTF+E+ N Sbjct: 256 QPQICTIDVYMVMVKCWMIDENIRPTFKELAN 287 >5X5O-A nrPDB Length = 310 Score = 61.6 bits (148), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 63/253 (24%), Positives = 111/253 (43%), Gaps = 32/253 (12%) Query: 45 GSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVI 104 G G FGSVY +S + VA+K + K I E+ + VL + F GVI Sbjct: 24 GGGSFGSVYRAKWISQDKEVAVKKLLK--IEKEAEILS--------VLSHRNIIQFYGVI 73 Query: 105 RLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW--QVLEAVRHCHN-- 160 P ++ ++ E + L+D+I + + ++ W V + + + H Sbjct: 74 L------EPPNYGIVTEYA-SLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEA 126 Query: 161 -CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYH 219 V+HRD+K N++I + G LK+ DFG+ T + GT + PE I+ Sbjct: 127 PVKVIHRDLKSRNVVIAAD-GVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPV- 184 Query: 220 GRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF----RQRVSSEC----QHLIRWCL 271 + +S G++L++M+ ++PF+ E + + R + S C L+ C Sbjct: 185 SETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCW 244 Query: 272 ALRPSDRPTFEEI 284 RP+F++I Sbjct: 245 EADAKKRPSFKQI 257 >1JNK-A nrPDB Length = 423 Score = 61.6 bits (148), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 67/271 (24%), Positives = 118/271 (43%), Gaps = 32/271 (11%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +YQ +GSG G V + + VAIK + + + + R E+VL+K V Sbjct: 63 RYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP----FQNQTHAKRAYRELVLMKCV 118 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA---------LQEELARSF 147 + +I LL+ F + E QD++ + A L E Sbjct: 119 NH--KNIISLLNVFTPQKTL-------EEFQDVYLVMELMDANLCQVIQMELDHERMSYL 169 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-VYTDFDGTRV 206 +Q+L ++H H+ G++HRD+K NI++ + LK++DFG + + T + TR Sbjct: 170 LYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLARTAGTSFMMTPYVVTRY 228 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHL 266 Y PE I Y + +WS+G ++ +MV I F + I + Q + + C Sbjct: 229 YRAPEVILGMGYK-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ-LGTPCPEF 286 Query: 267 IRWCLALRPSDRPTFEEIQNHPWMQDVLLPQ 297 ++ L+P+ R ++N P + P+ Sbjct: 287 MK---KLQPTVR---NYVENRPKYAGLTFPK 311 >3FI2-A nrPDB Length = 353 Score = 61.2 bits (147), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 67/272 (24%), Positives = 118/272 (43%), Gaps = 32/272 (11%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +YQ +GSG G V + + VAIK + + + + R E+VL+K Sbjct: 24 KRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP----FQNQTHAKRAYRELVLMKC 79 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA---------LQEELARS 146 V+ +I LL+ F + E QD++ + A L E Sbjct: 80 VNH--KNIISLLNVFTPQKTL-------EEFQDVYLVMELMDANLCQVIQMELDHERMSY 130 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-VYTDFDGTR 205 +Q+L ++H H+ G++HRD+K NI++ + LK++DFG + + T + TR Sbjct: 131 LLYQMLCGIKHLHSAGIIHRDLKPSNIVVK-SDCTLKILDFGLARTAGTSFMMTPYVVTR 189 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQH 265 Y PE I Y + +WS+G ++ +MV I F + I + Q + + C Sbjct: 190 YYRAPEVILGMGYK-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQ-LGTPCPE 247 Query: 266 LIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQ 297 ++ L+P+ R ++N P + P+ Sbjct: 248 FMK---KLQPTVR---NYVENRPKYAGLTFPK 273 >4PWN-A nrPDB Length = 274 Score = 61.2 bits (147), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 56/276 (20%), Positives = 115/276 (41%), Gaps = 47/276 (17%) Query: 44 LGSGGFGSVYSGIRVSDNLPVA--------IKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +G G F +VY G+ + VA + E+ R + E+ G + P Sbjct: 18 IGRGSFKTVYKGLDTETTVEVAWCELQDRKLTKSERQRFKEEAEMLKGLQHP-------- 69 Query: 96 VSSGFSGVIRLLDWFE---RPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 ++R D +E + ++++ L ++ ++ ++ RS+ Q+L Sbjct: 70 ------NIVRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQIL 123 Query: 153 EAVRHCHNCG--VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT-DFDGTRVYSP 209 + ++ H ++HRD+K +NI I G +K+ D G L K + GT + Sbjct: 124 KGLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMA 183 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSS-------- 261 PE Y + S V++ G+ + +M + P+ + Q++ +RV+S Sbjct: 184 PEM--YEEKYDESVDVYAFGMCMLEMATSEYPYSECQNA--AQIY--RRVTSGVKPASFD 237 Query: 262 -----ECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 E + +I C+ +R + +++ NH + Q+ Sbjct: 238 KVAIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQE 273 >3QA8-A nrPDB Length = 676 Score = 60.8 bits (146), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 94/208 (45%), Gaps = 15/208 (7%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS-SGFSG 102 LG+GGFG V I VAIK ++ N R +E+ ++KK++ Sbjct: 22 LGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPK-----NRERWCLEIQIMKKLNHPNVVS 76 Query: 103 VIRLLDWFER--PDSFVLILERPEPVQDLFDFITER---GALQEELARSFFWQVLEAVRH 157 + D ++ P+ L+ DL ++ + L+E R+ + A+R+ Sbjct: 77 AREVPDGLQKLAPNDLPLLAMEYCEGGDLRKYLNQFENCCGLKEGPIRTLLSDISSALRY 136 Query: 158 CHNCGVLHRDIKDENILIDLNRGEL--KLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIR 214 H ++HRD+K ENI++ L K+ID G + L + + T+F GT Y PE + Sbjct: 137 LHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTLQYLAPELLE 196 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPF 242 +Y + WS G L ++ + G PF Sbjct: 197 QKKYTV-TVDYWSFGTLAFECITGFRPF 223 >3PG1-A nrPDB Length = 362 Score = 60.8 bits (146), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 61/247 (24%), Positives = 105/247 (42%), Gaps = 39/247 (15%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM- 88 E ++S Y V + SG +G+V +G+ S+ +PVAIK V + + +G V + Sbjct: 16 ELHAMQSPYTVQRFISSGSYGAVCAGVD-SEGIPVAIKRV-------FNTVSDGRTVNIL 67 Query: 89 -EVVLLKKVSSGFSGVIRLLDWFERPDSFVL---ILERPEPVQDLFDFITE--------- 135 + L K+V IRLL+ F P+ L + EP +TE Sbjct: 68 SDSFLCKRVLRE----IRLLNHFHHPNILGLRDIFVHFEEPAMHKLYLVTELMRTDLAQV 123 Query: 136 ----RGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SG 190 R + + + F + +L + H GV+HRD+ NIL+ N ++ + DF + Sbjct: 124 IHDQRIVISPQHIQYFMYHILLGLHVLHEAGVVHRDLHPGNILLADN-NDITICDFNLAR 182 Query: 191 ALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIR 250 D T + R Y PE + + + +WS G ++ +M + + + R Sbjct: 183 EDTADANKTHYVTHRWYRAPELVMQFKGFTKLVDMWSAGCVMAEMF-------NRKALFR 235 Query: 251 GQVFFRQ 257 G F+ Q Sbjct: 236 GSTFYNQ 242 >2H8H-A nrPDB Length = 535 Score = 60.8 bits (146), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 46/150 (30%), Positives = 72/150 (48%), Gaps = 19/150 (12%) Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV--- 206 Q+ + + +HRD++ NIL+ N K+ DFG L++D YT G + Sbjct: 371 QIASGMAYVERMNYVHRDLRAANILVGENL-VCKVADFGLARLIEDNEYTARQGAKFPIK 429 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF------EHDEEIIRGQVFFRQRV 259 ++ PE Y R+ +S VWS GILL ++ G +P+ E +++ RG +R Sbjct: 430 WTAPEAALYGRFTIKS-DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPC 485 Query: 260 SSEC----QHLIRWCLALRPSDRPTFEEIQ 285 EC L+ C P +RPTFE +Q Sbjct: 486 PPECPESLHDLMCQCWRKEPEERPTFEYLQ 515 >5X8I-B nrPDB Length = 346 Score = 60.5 bits (145), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 65/236 (27%), Positives = 102/236 (43%), Gaps = 29/236 (12%) Query: 34 LESQYQVGPLLGSGGFGSVYSGI-RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVL 92 L ++Y++ LG G FG V I + VA+K V+ + + E +E + Sbjct: 11 LSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKN--VDRYCEAARSEIQVLEHLN 68 Query: 93 LKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEEL--ARSFFWQ 150 +S F V ++L+WFE ++ E +DFI E G L L R +Q Sbjct: 69 TTDPNSTFRCV-QMLEWFEHHGHICIVFELLG--LSTYDFIKENGFLPFRLDHIRKMAYQ 125 Query: 151 VLEAVRHCHNCGVLHRDIKDENILI-----------DLNRGE-------LKLIDFGSGAL 192 + ++V H+ + H D+K ENIL + R E +K++DFGS A Sbjct: 126 ICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGS-AT 184 Query: 193 LKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF-EHDEE 247 D ++ TR Y PE I + + VWS+G +L + G F HD + Sbjct: 185 YDDEHHSTLVSTRHYRAPEVILALGW-SQPCDVWSIGCILIEYYLGFTVFPTHDSK 239 >4YHJ-A nrPDB Length = 584 Score = 60.5 bits (145), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 81/313 (25%), Positives = 132/313 (42%), Gaps = 51/313 (16%) Query: 30 EKEPL-ESQYQVGPLLGSGGFGSVYS-GIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 E++P+ ++ ++ +LG GGFG V + +R + + K +K GE Sbjct: 178 ERQPVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGE----AMAL 233 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSF 147 E +L+KV S F V+ L +E D+ L+L DL I G + R+ Sbjct: 234 NEKRILEKVQSRF--VVSLAYAYETKDALCLVLTIMNG-GDLKFHIYNLGNPGFDEQRAV 290 Query: 148 FWQVLEAVRHCHNCG--------VLHRDIKDENILIDLNRGELKLIDFG------SGALL 193 F+ A C CG +++RD+K ENIL+D +RG +++ D G G + Sbjct: 291 FY----AAELC--CGLEDLQRERIVYRDLKPENILLD-DRGHIRISDLGLATEIPEGQRV 343 Query: 194 KDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF----------E 243 + V GT Y PE + +Y S W LG L+Y+M+ G PF E Sbjct: 344 RGRV-----GTVGYMAPEVVNNEKYTF-SPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEE 397 Query: 244 HDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDR-----PTFEEIQNHPWMQDVLLPQE 298 D+ I + ++ S + + + R L PS R ++ HP +D+ + Sbjct: 398 VDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRL 457 Query: 299 TAEIHLHSLSPGP 311 A + P P Sbjct: 458 EANMLEPPFCPDP 470 >2PVN-A nrPDB Length = 352 Score = 60.5 bits (145), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 62/265 (23%), Positives = 118/265 (44%), Gaps = 25/265 (9%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 + Y+V +G G + V+ GI V++N IK ++ + ++ E+ +L+ Sbjct: 51 QDDYEVVRKVGRGKYSEVFEGINVNNNEKCIIKILKPVKK---------KKIKREIKILQ 101 Query: 95 KVSSGFSGVIRLLDWFERPDSFV--LILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 + G +++LLD S LI E DF L + R + +++L Sbjct: 102 NLCGG-PNIVKLLDIVRDQHSKTPSLIFEYVNNT----DFKVLYPTLTDYDIRYYIYELL 156 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRVYSPPE 211 +A+ +CH+ G++HRD+K N++ID +L+LID+G Y +R + PE Sbjct: 157 KALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPE 216 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPF-----EHDEEIIRGQVFFRQRVSSECQHL 266 + + + S +WSLG + M+ PF HD+ + +V +++ +L Sbjct: 217 LLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNA---YL 273 Query: 267 IRWCLALRPSDRPTFEEIQNHPWMQ 291 ++ + L P PW++ Sbjct: 274 NKYRIELDPQLEALVGRHSRKPWLK 298 >3NIE-A nrPDB Length = 429 Score = 60.5 bits (145), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 56/236 (23%), Positives = 98/236 (41%), Gaps = 49/236 (20%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 Y++ L+G G +G VY + N VAIK V + + +L + R+ E+ +L ++ Sbjct: 29 NYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRM----FEDLIDCKRILREITILNRL 84 Query: 97 SSGFSGVIRLLDW-----FERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQV 151 S + +IRL D + D ++LE + DL L E+ ++ + + Sbjct: 85 KSDY--IIRLHDLIIPEDLLKFDELYIVLEIAD--SDLKKLFKTPIFLTEQHVKTILYNL 140 Query: 152 LEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD--------- 202 L + H G++HRD+K N L++ + +K+ DFG L T+ +D D Sbjct: 141 LLGEKFIHESGIIHRDLKPANCLLNQD-CSVKICDFG----LARTINSDKDIHIVNDLEE 195 Query: 203 ----------------------GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMV 236 TR Y PE I + S +WS G + +++ Sbjct: 196 KEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELL 251 >6F3F-A nrPDB Length = 455 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 46/150 (30%), Positives = 72/150 (48%), Gaps = 19/150 (12%) Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV--- 206 Q+ + + +HRD++ NIL+ N K+ DFG L++D YT G + Sbjct: 291 QIASGMAYVERMNYVHRDLRAANILVGENL-VCKVADFGLARLIEDNEYTARQGAKFPIK 349 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF------EHDEEIIRGQVFFRQRV 259 ++ PE Y R+ +S VWS GILL ++ G +P+ E +++ RG +R Sbjct: 350 WTAPEAALYGRFTIKS-DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPC 405 Query: 260 SSEC----QHLIRWCLALRPSDRPTFEEIQ 285 EC L+ C P +RPTFE +Q Sbjct: 406 PPECPESLHDLMCQCWRKEPEERPTFEYLQ 435 >5IKW-A nrPDB Length = 310 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 77/283 (27%), Positives = 116/283 (40%), Gaps = 48/283 (16%) Query: 25 LAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 84 A G+ + LE L GGF +V+ +R + A+K + + +P+ Sbjct: 9 FAVGRHQVTLEES------LAEGGFSTVFL-VRTHGGIRCALKRMYVNN------MPDLN 55 Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDS----FVLILE---RPEPVQDLFDFITERG 137 E+ ++K++S G ++ LD S VLIL R V + + + G Sbjct: 56 VCKREITIMKELS-GHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTG 114 Query: 138 ALQEELARSFFWQVLEAVRHCHNCG--VLHRDIKDENILIDLNRGELKLIDFGSGALLKD 195 + E+ + F EAV H C ++HRD+K ENIL++ + G L DFGS Sbjct: 115 FTEPEVLQ-IFCDTCEAVARLHQCKTPIIHRDLKVENILLN-DGGNYVLCDFGSAT--NK 170 Query: 196 TVYTDFDGTRV------------YSPPEWIRYHRYHGR----SAAVWSLGILLYDMVCGD 239 + DG V Y PE I + Y G+ A +W+LG LLY + Sbjct: 171 FLNPQKDGVNVVEEEIKKYTTLSYRAPEMI--NLYGGKPITTKADIWALGCLLYKLCFFT 228 Query: 240 IPFEHDEEIIRGQVFF---RQRVSSECQHLIRWCLALRPSDRP 279 +PF + I F R S LIR+ L P RP Sbjct: 229 LPFGESQVAICDGNFTIPDNSRYSRNIHCLIRFMLEPDPEHRP 271 >5SYS-A nrPDB Length = 286 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 46/150 (30%), Positives = 72/150 (48%), Gaps = 19/150 (12%) Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV--- 206 Q+ + + +HRD++ NIL+ N K+ DFG L++D YT G + Sbjct: 122 QIASGMAYVERMNYVHRDLRAANILVGENL-VCKVADFGLARLIEDNEYTARQGAKFPIK 180 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF------EHDEEIIRGQVFFRQRV 259 ++ PE Y R+ +S VWS GILL ++ G +P+ E +++ RG +R Sbjct: 181 WTAPEAALYGRFTIKS-DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERG---YRMPC 236 Query: 260 SSEC----QHLIRWCLALRPSDRPTFEEIQ 285 EC L+ C P +RPTFE +Q Sbjct: 237 PPECPESLHDLMCQCWRKDPEERPTFEYLQ 266 >3EB0-A nrPDB Length = 383 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 35/121 (28%), Positives = 58/121 (47%), Gaps = 1/121 (0%) Query: 129 LFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG 188 L FI ++ L + +Q+ AV H+ G+ HRDIK +N+L++ LKL DFG Sbjct: 128 LKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLCDFG 187 Query: 189 SG-ALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE 247 S L+ + +R Y PE + + S +WS+G + +++ G F + Sbjct: 188 SAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPLFSGETS 247 Query: 248 I 248 I Sbjct: 248 I 248 >3N9X-A nrPDB Length = 432 Score = 59.7 bits (143), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 56/229 (24%), Positives = 97/229 (42%), Gaps = 38/229 (16%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 Y + L+G G +G VY + VAIK V + + +L + R+ E+ +L ++ Sbjct: 27 NYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRM----FEDLIDCKRILREITILNRL 82 Query: 97 SSGFSGVIRLLDW-----FERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQV 151 S + +IRL D + D ++LE + DL L EE ++ + + Sbjct: 83 KSDY--IIRLYDLIIPDDLLKFDELYIVLEIAD--SDLKKLFKTPIFLTEEHIKTILYNL 138 Query: 152 LEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL---KDT-VYTDFDG---- 203 L H G++HRD+K N L++ + +K+ DFG + KDT + D + Sbjct: 139 LLGENFIHESGIIHRDLKPANCLLNQD-CSVKVCDFGLARTINSEKDTNIVNDLEENEEP 197 Query: 204 ----------------TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMV 236 TR Y PE I + +S +WS G + +++ Sbjct: 198 GPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELL 246 >5AWM-A nrPDB Length = 394 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 54/209 (25%), Positives = 93/209 (44%), Gaps = 25/209 (11%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 +GSG G V + VAIK + + + + + R E L+K V+ + Sbjct: 52 IGSGAQGIVCAAYDTITQQNVAIKKLSRP----FQNVTHAKRAYREFKLMKLVNH--KNI 105 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITERGA---------LQEELARSFFWQVLEA 154 I LL+ F + E QD++ + A L + +Q+L Sbjct: 106 IGLLNAFTPQRNL-------EEFQDVYLVMELMDANLCQVIQMDLDHDRMSYLLYQMLCG 158 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-VYTDFDGTRVYSPPEWI 213 ++H H+ G++HRD+K NI++ + LK++DFG T + T + TR Y PE I Sbjct: 159 IKHLHSAGIIHRDLKPSNIVVKAD-CTLKILDFGLARTAGTTFMMTPYVVTRYYRAPEVI 217 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPF 242 Y + +WS+G ++ +M+ G + F Sbjct: 218 LGMGY-TENVDIWSVGCIMGEMIRGGVLF 245 >6HXF-B nrPDB Length = 302 Score = 58.9 bits (141), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 65/270 (24%), Positives = 114/270 (42%), Gaps = 34/270 (12%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVE---KDRISDWGELPNGTRVPMEVVLLKKVSSGF 100 LG G FG VY A K +E ++ + D+ +E+ +L + Sbjct: 27 LGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDY---------IVEIEILATCDHPY 77 Query: 101 SGVIRLLDWFERPDSFVLILER-PEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 159 +++LL + +++E P D +RG L E + Q+LEA+ H Sbjct: 78 --IVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRG-LTEPQIQVVCRQMLEALNFLH 134 Query: 160 NCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT--DFDGTRVYSPPEWIRYHR 217 + ++HRD+K N+L+ L G+++L DFG A T+ F GT + PE + Sbjct: 135 SKRIIHRDLKAGNVLMTLE-GDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCET 193 Query: 218 Y----HGRSAAVWSLGILLYDMVCGDIPFEHDEEIIR----------GQVFFRQRVSSEC 263 + A +WSLGI L +M + P H+ +R + + S E Sbjct: 194 MKDTPYDYKADIWSLGITLIEMAQIEPP-HHELNPMRVLLKIAKSDPPTLLTPSKWSVEF 252 Query: 264 QHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 + ++ L P RP+ ++ HP++ + Sbjct: 253 RDFLKIALDKNPETRPSAAQLLEHPFVSSI 282 >4OW8-A nrPDB Length = 283 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 61/222 (27%), Positives = 90/222 (40%), Gaps = 20/222 (9%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 L +Y++ L+ +GG G V+ + VA+K V K S E R + Sbjct: 9 LSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVK-VLKSEFSSDPEFIERFRAEARTTAM 67 Query: 94 KKVSSGFSGVIRLLDWFE-------RPDSFVLILERPEPVQDLFDFITERGALQEELARS 146 G+ + D+ E R V+ L EP L + G L A Sbjct: 68 LN----HPGIASVHDYGESQMNGEGRTAYLVMELVNGEP---LNSVLKRTGRLSLRHALD 120 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD---G 203 Q A++ H G++HRD+K NILI G++K+ DFG + T G Sbjct: 121 MLEQTGRALQIAHAAGLVHRDVKPGNILITPT-GQVKITDFGIAKAVDAAPVTQTGMVMG 179 Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD 245 T Y PE H ++ V+SLG++ Y+ V G PF D Sbjct: 180 TAQYIAPEQALGHDAS-PASDVYSLGVVGYEAVSGKRPFAGD 220 >3SXS-A nrPDB Length = 268 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 65/253 (25%), Positives = 116/253 (45%), Gaps = 25/253 (9%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 LGSG FG V G + VA+K +++ +S+ E + M++ K V F GV Sbjct: 16 LGSGQFGVVKLG-KWKGQYDVAVKMIKEGSMSE-DEFFQEAQTMMKLSHPKLVK--FYGV 71 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQVLEAVRHCHNCG 162 E P + I+ L +++ G L+ + V E + + Sbjct: 72 CSK----EYP---IYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQ 124 Query: 163 VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---YSPPEWIRYHRYH 219 +HRD+ N L+D + +K+ DFG + D Y GT+ +S PE Y +Y Sbjct: 125 FIHRDLAARNCLVDRDLC-VKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYS 183 Query: 220 GRSAAVWSLGILLYDMVC-GDIPFE--HDEEII----RGQVFFRQRVSSECQHLIRW-CL 271 +S VW+ GIL++++ G +P++ + E++ +G +R ++S+ + I + C Sbjct: 184 SKS-DVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLASDTIYQIMYSCW 242 Query: 272 ALRPSDRPTFEEI 284 P RPTF+++ Sbjct: 243 HELPEKRPTFQQL 255 >4X3F-A nrPDB Length = 337 Score = 58.5 bits (140), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 61/222 (27%), Positives = 90/222 (40%), Gaps = 20/222 (9%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 L +Y++ L+ +GG G V+ + VA+K V K S E R + Sbjct: 10 LSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVK-VLKSEFSSDPEFIERFRAEARTTAM 68 Query: 94 KKVSSGFSGVIRLLDWFE-------RPDSFVLILERPEPVQDLFDFITERGALQEELARS 146 G+ + D+ E R V+ L EP L + G L A Sbjct: 69 LN----HPGIASVHDYGESQMNGEGRTAYLVMELVNGEP---LNSVLKRTGRLSLRHALD 121 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD---G 203 Q A++ H G++HRD+K NILI G++K+ DFG + T G Sbjct: 122 MLEQTGRALQIAHAAGLVHRDVKPGNILITPT-GQVKITDFGIAKAVDAAPVTQTGMVMG 180 Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD 245 T Y PE H ++ V+SLG++ Y+ V G PF D Sbjct: 181 TAQYIAPEQALGHDAS-PASDVYSLGVVGYEAVSGKRPFAGD 221 >6B2Q-A nrPDB Length = 317 Score = 58.2 bits (139), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 61/222 (27%), Positives = 90/222 (40%), Gaps = 20/222 (9%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 L +Y++ L+ +GG G V+ + VA+K V K S E R + Sbjct: 30 LSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVK-VLKSEFSSDPEFIERFRAEARTTAM 88 Query: 94 KKVSSGFSGVIRLLDWFE-------RPDSFVLILERPEPVQDLFDFITERGALQEELARS 146 G+ + D+ E R V+ L EP L + G L A Sbjct: 89 LN----HPGIASVHDYGESQMNGEGRTAYLVMELVNGEP---LNSVLKRTGRLSLRHALD 141 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD---G 203 Q A++ H G++HRD+K NILI G++K+ DFG + T G Sbjct: 142 MLEQTGRALQIAHAAGLVHRDVKPGNILITPT-GQVKITDFGIAKAVDAAPVTQTGMVMG 200 Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD 245 T Y PE H ++ V+SLG++ Y+ V G PF D Sbjct: 201 TAQYIAPEQALGHDAS-PASDVYSLGVVGYEAVSGKRPFAGD 241 >3UIM-A nrPDB Length = 326 Score = 57.8 bits (138), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 62/217 (28%), Positives = 102/217 (47%), Gaps = 33/217 (15%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 +LG GGFG VY G R++D VA+K ++++R + GEL T V M + + + Sbjct: 37 ILGRGGFGKVYKG-RLADGTLVAVKRLKEER-TQGGELQFQTEVEMISMAVHR------N 88 Query: 103 VIRLLDWFERPDSFVLIL-------------ERPEPVQDLFDFITERGALQEELARSFFW 149 ++RL + P +L+ ERPE L +R AL ++ Sbjct: 89 LLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQRIALGSARGLAYLH 148 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDT-VYTDFDGTRV 206 HC + ++HRD+K NIL+D E + DFG L+ KDT V T GT Sbjct: 149 D------HC-DPKIIHRDVKAANILLD-EEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIG 200 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE 243 + PE++ + ++ V+ G++L +++ G F+ Sbjct: 201 HIAPEYLSTGKSSEKT-DVFGYGVMLLELITGQRAFD 236 >5HIE-A nrPDB Length = 302 Score = 57.8 bits (138), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 69/277 (24%), Positives = 118/277 (42%), Gaps = 52/277 (18%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 + Q VG +GSG FG+VY G D VA+K + ++ + R V +L Sbjct: 35 DGQITVGQRIGSGSFGTVYKGKWHGD---VAVKMLTPQQLQAFKNEVGVLRKTRHVNIL- 90 Query: 95 KVSSGFSGVIRL---LDWFERPDSF--VLILERPEPVQDLFDFITERGALQEELARSFFW 149 + G+S +L W E + + I+E + L D +AR Sbjct: 91 -LFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLID-----------IAR---- 134 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILI--DLNRGELKLIDFGSGALLK----DTVYTDFDG 203 Q + + + H ++HRD+K NI + DL +K+ DFG + + G Sbjct: 135 QTAQGMDYLHAKSIIHRDLKSNNIFLHEDLT---VKIGDFGLATVKSRWSGSHQFEQLSG 191 Query: 204 TRVYSPPEWIRYHRYHGRS--AAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR----- 256 + ++ PE IR + S + V++ GI+LY+++ G +P+ + R Q+ F Sbjct: 192 SILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINN--RDQIIFMVGRGY 249 Query: 257 -----QRVSSEC----QHLIRWCLALRPSDRPTFEEI 284 +V S C + L+ CL + +RP F +I Sbjct: 250 LSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQI 286 >5TQX-A nrPDB Length = 655 Score = 57.8 bits (138), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 55/213 (25%), Positives = 97/213 (45%), Gaps = 22/213 (10%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 LG+GGFG+V +L +AIK + + N R E+ ++KK++ + V Sbjct: 16 LGTGGFGNVCLYQHRELDLKIAIKSCRLELSTK-----NRERWCHEIQIMKKLN--HANV 68 Query: 104 IRLLDWFERPDSFVLILERP---------EPVQDLFDFITERGALQEELARSFFWQVLEA 154 ++ D E + +LI + P ++ L + L+E S + Sbjct: 69 VKACDVPEELN--ILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSG 126 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGEL--KLIDFGSGA-LLKDTVYTDFDGTRVYSPPE 211 +R+ H ++HRD+K ENI++ G++ K+ID G + + + T+F GT Y PE Sbjct: 127 IRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQYLAPE 186 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH 244 Y + WS G ++++ + G PF H Sbjct: 187 LFENKPYTA-TVDYWSFGTMVFECIAGYRPFLH 218 >4H1J-A nrPDB Length = 293 Score = 57.4 bits (137), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 61/257 (23%), Positives = 120/257 (46%), Gaps = 26/257 (10%) Query: 43 LLGSGGFGSVYSGIRVS---DNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 99 +LG G FG VY G+ + + + VA+K +KD D N + E V++K + Sbjct: 31 ILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLD-----NKEKFMSEAVIMKNLDH- 84 Query: 100 FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT-ERGALQEELARSFFWQVLEAVRHC 158 +++L+ E +++++ P +L ++ + +L+ + Q+ +A+ + Sbjct: 85 -PHIVKLIGIIEEEPTWIIM--ELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL 141 Query: 159 HNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---YSPPEWIRY 215 + +HRDI NIL+ +KL DFG ++D Y TR+ + PE I + Sbjct: 142 ESINCVHRDIAVRNILVASPEC-VKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINF 200 Query: 216 HRYHGRSAAVWSLGILLYDMVC-GDIPF--EHDEEII----RGQVFFRQRVSSECQH-LI 267 R+ ++ VW + +++++ G PF ++++I +G + + + L+ Sbjct: 201 RRF-TTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLM 259 Query: 268 RWCLALRPSDRPTFEEI 284 C PSDRP F E+ Sbjct: 260 TRCWDYDPSDRPRFTEL 276 >6BXI-A nrPDB Length = 333 Score = 57.4 bits (137), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 56/236 (23%), Positives = 98/236 (41%), Gaps = 43/236 (18%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 ++G G FG V + A+K + K +D E + E +L + S + Sbjct: 13 VIGRGAFGEVRLVQKKDTGHVYAMKILRK---ADMLEKEQVGHIRAERDILVEADSLW-- 67 Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCG 162 V+++ F+ + LI+E P D+ + ++ L EE + + + + A+ H G Sbjct: 68 VVKMFYSFQDKLNLYLIMEFL-PGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSIHQLG 126 Query: 163 VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRS 222 +HRDIK +N+L+D ++G +KL DFG LK T+F +S P + + + Sbjct: 127 FIHRDIKPDNLLLD-SKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTFQNMNSKR 185 Query: 223 AAV------------------------------------WSLGILLYDMVCGDIPF 242 A WSLG+++Y+M+ G PF Sbjct: 186 KAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYNKLCDWWSLGVIMYEMLIGYPPF 241 >5L2Q-C nrPDB Length = 320 Score = 57.4 bits (137), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 42/165 (25%), Positives = 72/165 (43%), Gaps = 18/165 (10%) Query: 128 DLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDF 187 +L ++ + L E F+ V+ V H ++HRD+K N++++ + + +F Sbjct: 139 NLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNF 198 Query: 188 GSGALL--KDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD 245 G L + + D G+ Y P+ + Y G+ + +W+LG++L+ M+ G PF Sbjct: 199 CLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDS 258 Query: 246 EEIIRGQVFFRQ------------RVSSECQHLIRWCLALRPSDR 278 Q FR+ RVS LIR L L P R Sbjct: 259 IP----QELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQR 299 >3DKO-A nrPDB Length = 318 Score = 57.4 bits (137), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 70/283 (24%), Positives = 127/283 (44%), Gaps = 51/283 (18%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSG---IRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 KE S ++ ++G+G FG V SG + ++ VAIK Sbjct: 38 KELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIK-------------------T 78 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVL--ILERPEPVQDLFDFITERGALQEELAR 145 ++V +K F ++ F+ P+ L ++ R +PV + +F+ E GAL L + Sbjct: 79 LKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFM-ENGALDAFLRK 137 Query: 146 -----------SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK 194 + +R+ + G +HRD+ NIL++ N K+ DFG +++ Sbjct: 138 HDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNL-VCKVSDFGLSRVIE 196 Query: 195 D---TVYTDFDGT--RVYSPPEWIRYHRYHGRSAAVWSLGILLYD-MVCGDIPF--EHDE 246 D VYT G ++ PE I+Y ++ S VWS GI++++ M G+ P+ ++ Sbjct: 197 DDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSAS-DVWSYGIVMWEVMSYGERPYWDMSNQ 255 Query: 247 EIIRG-QVFFRQRVSSEC----QHLIRWCLALRPSDRPTFEEI 284 ++I+ + +R +C L+ C ++RP FE+I Sbjct: 256 DVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQI 298 >3UIU-A nrPDB Length = 306 Score = 57.4 bits (137), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 47/155 (30%), Positives = 79/155 (50%), Gaps = 17/155 (10%) Query: 139 LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTV 197 L + LA F Q+ + V + H+ ++HRD+K NI + ++ ++K+ DFG LK D Sbjct: 133 LDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFL-VDTKQVKIGDFGLVTSLKNDGK 191 Query: 198 YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDM--VCGDIPFEHDE------EII 249 T GT Y PE I Y G+ +++LG++L ++ VC D FE + + I Sbjct: 192 RTRSKGTLRYMSPEQISSQDY-GKEVDLYALGLILAELLHVC-DTAFETSKFFTDLRDGI 249 Query: 250 RGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEI 284 +F ++ + L++ L+ +P DRP EI Sbjct: 250 ISDIFDKKE-----KTLLQKLLSKKPEDRPNTSEI 279 >5LPZ-A nrPDB Length = 332 Score = 57.0 bits (136), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 67/217 (30%), Positives = 100/217 (46%), Gaps = 37/217 (17%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIK---HV--EKDR-----ISDWGELPNGTRVPMEVVL 92 L+GSGGFG VY I + D VAIK HV + DR + G++ + VP L Sbjct: 24 LIGSGGFGDVYKAI-LKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVP----L 78 Query: 93 LKKVSSGFSGVIRLLDW-FERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQ 150 L G RLL + F + S +L P+ ++ T R A+ +F Sbjct: 79 LGYCKVGDE---RLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLH- 134 Query: 151 VLEAVRHCHNCG--VLHRDIKDENILIDLNRGELKLIDFGSGALLK--DT--VYTDFDGT 204 HNC ++HRD+K N+L+D N E ++ DFG L+ DT + GT Sbjct: 135 --------HNCSPHIIHRDMKSSNVLLDENL-EARVSDFGMARLMSAMDTHLSVSTLAGT 185 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIP 241 Y PPE+ + R + V+S G++L +++ G P Sbjct: 186 PGYVPPEYYQSFRCSTK-GDVYSYGVVLLELLTGKRP 221 >5LPV-A nrPDB Length = 296 Score = 57.0 bits (136), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 65/217 (29%), Positives = 100/217 (46%), Gaps = 37/217 (17%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIK---HV--EKDR-----ISDWGELPNGTRVPMEVVL 92 L+GSGGFG VY I + D VAIK HV + DR + G++ + VP+ Sbjct: 24 LIGSGGFGDVYKAI-LKDGSAVAIKKLIHVSGQGDREFMAEMETIGKIKHRNLVPL---- 78 Query: 93 LKKVSSGFSGVIRLLDW-FERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQ 150 + G RLL + F + S +L P+ ++ T R A+ +F Sbjct: 79 ---LGYCKVGDERLLVYEFMKYGSLEDVLHDPKKAGVKLNWSTRRKIAIGSARGLAFLH- 134 Query: 151 VLEAVRHCHNCG--VLHRDIKDENILIDLNRGELKLIDFGSGALLK--DT--VYTDFDGT 204 HNC ++HRD+K N+L+D N E ++ DFG L+ DT + GT Sbjct: 135 --------HNCSPHIIHRDMKSSNVLLDENL-EARVSDFGMARLMSAMDTHLSVSTLAGT 185 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIP 241 Y PPE+ + R + V+S G++L +++ G P Sbjct: 186 PGYVPPEYYQSFRCSTK-GDVYSYGVVLLELLTGKRP 221 >3PP0-A nrPDB Length = 338 Score = 57.0 bits (136), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 60/221 (27%), Positives = 105/221 (47%), Gaps = 25/221 (11%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSD----NLPVAIKHVEKDRISDWGELPNGTRVPM-E 89 E++ + +LGSG FG+VY GI + D +PVAIK + ++ P + + E Sbjct: 16 ETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLREN------TSPKANKEILDE 69 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSFF 148 ++ V S + V RLL S V ++ + P L D + E RG L + ++ Sbjct: 70 AYVMAGVGSPY--VSRLLGICL--TSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWC 125 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRVY 207 Q+ + + + + ++HRD+ N+L+ + +K+ DFG LL D DG +V Sbjct: 126 MQIAKGMSYLEDVRLVHRDLAARNVLVK-SPNHVKITDFGLARLLDIDETEYHADGGKV- 183 Query: 208 SPPEWIRYH----RYHGRSAAVWSLGILLYD-MVCGDIPFE 243 P +W+ R + VWS G+ +++ M G P++ Sbjct: 184 -PIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYD 223 >4PDO-A nrPDB Length = 299 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 69/268 (25%), Positives = 116/268 (43%), Gaps = 44/268 (16%) Query: 43 LLGSGGFGSVYSGIRVSDN----LPVAIK-----HVEKDRISDWGELPNGTRVPMEVVLL 93 ++G+G FG VY G+ + + +PVAIK + EK R+ GE Sbjct: 41 VIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGE-------------- 86 Query: 94 KKVSSGFS--GVIRLLDWFERPDSFVLILERPEPVQDLFDFITER-GALQEELARSFFWQ 150 + FS +IRL + ++I E E L F+ E+ G Sbjct: 87 AGIMGQFSHHNIIRLEGVISKYKPMMIITEYMEN-GALDKFLREKDGEFSVLQLVGMLRG 145 Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD---TVYTDFDGTRV- 206 + +++ N +HRD+ NIL++ N K+ DFG +L+D YT G ++ Sbjct: 146 IAAGMKYLANMNYVHRDLAARNILVNSNL-VCKVSDFGLSRVLEDDPEATYTT-SGGKIP 203 Query: 207 --YSPPEWIRYHRYHGRSAAVWSLGILLYD-MVCGDIPFEH--DEEIIRG-QVFFRQRVS 260 ++ PE I Y ++ S VWS GI++++ M G+ P+ + E+++ FR Sbjct: 204 IRWTAPEAISYRKFTSAS-DVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTP 262 Query: 261 SEC----QHLIRWCLALRPSDRPTFEEI 284 +C L+ C + RP F +I Sbjct: 263 MDCPSAIYQLMMQCWQQERARRPKFADI 290 >1U5R-A nrPDB Length = 348 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 69/260 (26%), Positives = 108/260 (41%), Gaps = 31/260 (11%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVE---KDRISDWGELPNGTRVPMEVVLLKKVSSGF 100 +G G FG+VY V ++ VAIK + K W ++ EV L+K+ Sbjct: 62 IGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQDIIK------EVRFLQKLRH-- 113 Query: 101 SGVIRLLDWFERPDSFVLILERP-EPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 159 I+ + R + L++E DL + + LQE + L+ + + H Sbjct: 114 PNTIQYRGCYLREHTAWLVMEYCLGSASDLLE--VHKKPLQEVEIAAVTHGALQGLAYLH 171 Query: 160 NCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYH--- 216 + ++HRD+K NIL+ G +KL DFGS +++ F GT + PE I Sbjct: 172 SHNMIHRDVKAGNILLS-EPGLVKLGDFGSASIMAPA--NSFVGTPYWMAPEVILAMDEG 228 Query: 217 RYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQ---------HLI 267 +Y G+ VWSLGI ++ P + + Q S Q + + Sbjct: 229 QYDGK-VDVWSLGITCIELAERKPPL-FNMNAMSALYHIAQNESPALQSGHWSEYFRNFV 286 Query: 268 RWCLALRPSDRPTFEEIQNH 287 CL P DRPT E + H Sbjct: 287 DSCLQKIPQDRPTSEVLLKH 306 >5FQD-C nrPDB Length = 341 Score = 56.6 bits (135), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 45/165 (27%), Positives = 82/165 (49%), Gaps = 18/165 (10%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVV--LLK 94 +Y++ +GSG FG +Y I +++ VA+K +E + R P + L Sbjct: 20 KYKLVRKIGSGSFGDIYLAINITNGEEVAVK-LESQK----------ARHPQLLYESKLY 68 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITERGALQEELARSFFWQVLE 153 K+ G G+ + + + D VL+++ P ++DLF+F + R ++ L + Q++ Sbjct: 69 KILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLA--DQMIS 126 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNR--GELKLIDFGSGALLKDT 196 + + H +HRDIK +N L+ + R +L LIDFG +D Sbjct: 127 RIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDN 171 >2R2P-A nrPDB Length = 295 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 70/285 (24%), Positives = 127/285 (44%), Gaps = 51/285 (17%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSG---IRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 KE S + ++G+G FG V SG + LPVAIK Sbjct: 17 KEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIK-------------------T 57 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVL--ILERPEPVQDLFDFITERGALQEELAR 145 ++V +K F G ++ F+ P+ L ++ + +PV + +++ E G+L L + Sbjct: 58 LKVGYTEKQRRDFLGEASIMGQFDHPNIIHLEGVVTKSKPVMIVTEYM-ENGSLDTFLKK 116 Query: 146 S-----------FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK 194 + + +++ + G +HRD+ NILI+ N K+ DFG +L+ Sbjct: 117 NDGQFTVIQLVGMLRGISAGMKYLSDMGYVHRDLAARNILINSNL-VCKVSDFGLSRVLE 175 Query: 195 D---TVYTDFDGT--RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF--EHDE 246 D YT G ++ PE I + ++ S VWS GI+++++V G+ P+ ++ Sbjct: 176 DDPEAAYTTRGGKIPIRWTAPEAIAFRKFTSAS-DVWSYGIVMWEVVSYGERPYWEMTNQ 234 Query: 247 EIIRG-QVFFRQRVSSEC----QHLIRWCLALRPSDRPTFEEIQN 286 ++I+ + +R +C L+ C + RP F+EI N Sbjct: 235 DVIKAVEEGYRLPSPMDCPAALYQLMLDCWQKERNSRPKFDEIVN 279 >1ZXE-A nrPDB Length = 303 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 74/304 (24%), Positives = 127/304 (41%), Gaps = 71/304 (23%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVE--KDRISDWGELPNGTRVPMEVVLL 93 S ++ +LG G FG V D+ AIK + ++++S + EV+LL Sbjct: 6 SDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLST---------ILSEVMLL 56 Query: 94 KKVSSGFSGVIRLLD-WFERPD------------SFVLILERPEPVQDLFDFI-TERGAL 139 ++ + V+R W ER + + + +E E + L+D I +E Sbjct: 57 ASLNHQY--VVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCEN-RTLYDLIHSENLNQ 113 Query: 140 QEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT 199 Q + F Q+LEA+ + H+ G++HR++K NI ID +R +K+ DFG L V+ Sbjct: 114 QRDEYWRLFRQILEALSYIHSQGIIHRNLKPMNIFIDESRN-VKIGDFG----LAKNVHR 168 Query: 200 DFD--------------------GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGD 239 D GT +Y E + ++ ++SLGI+ ++M+ Sbjct: 169 SLDILKLDSQNLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY-- 226 Query: 240 IPFEHDEEIIRGQVFFRQR-VSSEC------------QHLIRWCLALRPSDRPTFEEIQN 286 PF E R + + R VS E + +IR + P+ RP + N Sbjct: 227 -PFSTGME--RVNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLN 283 Query: 287 HPWM 290 W+ Sbjct: 284 SGWL 287 >2GCD-A nrPDB Length = 309 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 70/259 (27%), Positives = 110/259 (42%), Gaps = 29/259 (11%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT--RVPMEVVLLKKVSSGFS 101 +G G FG+VY V ++ VAIK ++S G+ N + EV L+K+ Sbjct: 23 IGHGSFGAVYFARDVRNSEVVAIK-----KMSYSGKQSNEKWQDIIKEVRFLQKLRH--P 75 Query: 102 GVIRLLDWFERPDSFVLILERP-EPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHN 160 I+ + R + L++E DL + + LQE + L+ + + H+ Sbjct: 76 NTIQYRGCYLREHTAWLVMEYCLGSASDLLE--VHKKPLQEVEIAAVTHGALQGLAYLHS 133 Query: 161 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYH---R 217 ++HRD+K NIL+ G +KL DFGS +++ F GT + PE I + Sbjct: 134 HNMIHRDVKAGNILLS-EPGLVKLGDFGSASIMAPA--NSFVGTPYWMAPEVILAMDEGQ 190 Query: 218 YHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQ---------HLIR 268 Y G+ VWSLGI ++ P + + Q S Q + + Sbjct: 191 YDGK-VDVWSLGITCIELAERKPPL-FNMNAMSALYHIAQNESPALQSGHWSEYFRNFVD 248 Query: 269 WCLALRPSDRPTFEEIQNH 287 CL P DRPT E + H Sbjct: 249 SCLQKIPQDRPTSEVLLKH 267 >4KIK-B nrPDB Length = 677 Score = 56.2 bits (134), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 53/216 (24%), Positives = 96/216 (44%), Gaps = 19/216 (8%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 +++ LG+GGFG+V +AIK ++ N R +E+ ++++++ Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPR-----NRERWCLEIQIMRRLT 75 Query: 98 SGFSGVIRLLDWFE-----RPDSFVLILERPEPVQDLFDFITER---GALQEELARSFFW 149 V+ D E P+ L+ DL ++ + L+E + Sbjct: 76 --HPNVVAARDVPEGMQNLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREGAILTLLS 133 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL--KLIDFG-SGALLKDTVYTDFDGTRV 206 + A+R+ H ++HRD+K ENI++ L K+ID G + L + ++ T F GT Sbjct: 134 DIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQ 193 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF 242 Y PE + +Y + WS G L ++ + G PF Sbjct: 194 YLAPELLEQQKYTV-TVDYWSFGTLAFECITGFRPF 228 >1G3N-A nrPDB Length = 326 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 74/314 (23%), Positives = 123/314 (39%), Gaps = 53/314 (16%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDN-LPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 + QY+ +G G +G V+ + + VA+K V GE EV +L Sbjct: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVR----VQTGEEGMPLSTIREVAVL 65 Query: 94 KKVSS-GFSGVIRLLDW-----FERPDSFVLILERPEPVQDL---FDFITERGALQEELA 144 + + + V+RL D +R L+ E + QDL D + E G E + Sbjct: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD--QDLTTYLDKVPEPGVPTETI- 122 Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDG 203 + +Q+L + H+ V+HRD+K +NIL+ + G++KL DFG + T Sbjct: 123 KDMMFQLLRGLDFLHSHRVVHRDLKPQNILV-TSSGQIKLADFGLARIYSFQMALTSVVV 181 Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDM------------------VCGDIPFEHD 245 T Y PE + Y +WS+G + +M + I + Sbjct: 182 TLWYRAPEVLLQSSY-ATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE 240 Query: 246 EEIIRGQVFFRQRVSSEC---------------QHLIRWCLALRPSDRPTFEEIQNHPWM 290 E+ R RQ S+ + L+ CL P+ R + +HP+ Sbjct: 241 EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300 Query: 291 QDVLLPQETAEIHL 304 QD+ +E + HL Sbjct: 301 QDLERCKENLDSHL 314 >6CTH-A nrPDB Length = 309 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 60/230 (26%), Positives = 94/230 (40%), Gaps = 20/230 (8%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 89 E + S + LG GGFGSVY G + +A+K V R S G + V + Sbjct: 9 ELAKVTSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKV--SRASKQGIKEYASEVKII 66 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 L K +++L+ W +L+ E + L E+ Sbjct: 67 SRLRHK------NLVKLIGWCHERGELMLVYEFMANGSLDSHIFKGKSLLTWEVRYRIVK 120 Query: 150 QVLEAVRHCHNCG---VLHRDIKDENILIDLNRGELKLIDFGSGALL---KDTVYTDFDG 203 + A+ + H G VLHRDIK NI++D + KL DFG L+ K T G Sbjct: 121 DLASALLYLHEEGDHCVLHRDIKTSNIMLD-SSFNAKLGDFGLARLVDHAKGLKKTLLAG 179 Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCG----DIPFEHDEEII 249 T Y PE + + + + V+S G++ ++ G + FE E ++ Sbjct: 180 TVGYMAPECLSSGK-ASKESDVYSFGVVALEIASGRRSIEPKFEESEALL 228 >4LRM-A nrPDB Length = 334 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 54/222 (24%), Positives = 107/222 (48%), Gaps = 24/222 (10%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSD----NLPVAIKHVEKDRISDWGELPNGTRVPM-E 89 E++++ +LGSG FG+VY G+ + + +PVAIK + + P + + E Sbjct: 18 ETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRE------ATSPKANKEILDE 71 Query: 90 VVLLKKVSS-GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSF 147 ++ V + G V RLL S V ++ + P L D++ E + + + ++ Sbjct: 72 AYVMASVDNPGNPHVCRLLGICL--TSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNW 129 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL-KDTVYTDFDGTRV 206 Q+ + + + + ++HRD+ N+L+ + +K+ DFG LL + +G +V Sbjct: 130 CVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQ-HVKITDFGLAKLLGAEEKEYHAEGGKV 188 Query: 207 YSPPEWIR----YHRYHGRSAAVWSLGILLYD-MVCGDIPFE 243 P +W+ HR + + VWS G+ +++ M G P++ Sbjct: 189 --PIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYD 228 >3LZB-A nrPDB Length = 327 Score = 55.1 bits (131), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 61/269 (22%), Positives = 124/269 (46%), Gaps = 32/269 (11%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSD----NLPVAIKHVEKDRISDWGELPNGTRVPM-E 89 E++++ +LGSG FG+VY G+ + + +PVAIK + + P + + E Sbjct: 14 ETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRE------ATSPKANKEILDE 67 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSFF 148 ++ V + V RLL S V ++ + P L D++ E + + + ++ Sbjct: 68 AYVMASVDN--PHVCRLLGIC--LTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWC 123 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL-KDTVYTDFDGTRVY 207 Q+ + + + + ++HRD+ N+L+ + +K+ DFG LL + +G +V Sbjct: 124 VQIAKGMNYLEDRRLVHRDLAARNVLVKTPQ-HVKITDFGLAKLLGAEEKEYHAEGGKV- 181 Query: 208 SPPEWIR----YHRYHGRSAAVWSLGILLYD-MVCGDIPF------EHDEEIIRGQVFFR 256 P +W+ HR + + VWS G+ +++ M G P+ E + +G+ + Sbjct: 182 -PIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQ 240 Query: 257 QRVSS-ECQHLIRWCLALRPSDRPTFEEI 284 + + + ++R C + RP F E+ Sbjct: 241 PPICTIDVYMIMRKCWMIDADSRPKFREL 269 >5HI2-A nrPDB Length = 283 Score = 54.7 bits (130), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 63/268 (23%), Positives = 115/268 (42%), Gaps = 34/268 (12%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 + Q VG +GSG FG+VY G D VA+K + ++ + R V +L Sbjct: 19 DGQITVGQRIGSGSFGTVYKGKWHGD---VAVKMLTPQQLQAFKNEVGVLRKTRHVNILL 75 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 + + ++ + S L E ++ I ++AR Q Sbjct: 76 FMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLI--------DIAR----QTARG 123 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK----DTVYTDFDGTRVYSPP 210 + + H ++HRD+K NI + + +K+ DFG + + G+ ++ P Sbjct: 124 MDYLHAKSIIHRDLKSNNIFLHED-NTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAP 182 Query: 211 EWIRYHRYHGRS--AAVWSLGILLYDMVCGDIPF---EHDEEII----RGQVF-FRQRVS 260 E IR + S + V++ GI+LY+++ G +P+ + ++II RG + +V Sbjct: 183 EVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVR 242 Query: 261 SEC----QHLIRWCLALRPSDRPTFEEI 284 S C + L+ CL + +RP+F I Sbjct: 243 SNCPKRMKRLMAECLKKKRDERPSFPRI 270 >2WO6-A nrPDB Length = 382 Score = 54.7 bits (130), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 57/227 (25%), Positives = 100/227 (44%), Gaps = 16/227 (7%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 K E +Y++ L+G G FG V + VAIK ++ + N ++ + Sbjct: 47 KNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKK-----AFLNQAQIEV 101 Query: 89 EVV-LLKKVSSGFS-GVIRLLDWFERPDSFVLILERPEPVQDLFDFI--TERGALQEELA 144 ++ L+ K + ++ L F + L+ E +L+D + T + L Sbjct: 102 RLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLS--YNLYDLLRNTNFRGVSLNLT 159 Query: 145 RSFFWQVLEAVRHCHN--CGVLHRDIKDENILI-DLNRGELKLIDFGSGALLKDTVYTDF 201 R F Q+ A+ ++H D+K ENIL+ + R +K++DFGS L +Y + Sbjct: 160 RKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIY-QY 218 Query: 202 DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEI 248 +R Y PE + Y + +WSLG +L +M G+ F E+ Sbjct: 219 IQSRFYRSPEVLLGMPY-DLAIDMWSLGCILVEMHTGEPLFSGANEV 264 >3RP9-A nrPDB Length = 458 Score = 54.7 bits (130), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 59/259 (22%), Positives = 109/259 (42%), Gaps = 58/259 (22%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +Y++ L+G+G +G V + VAIK + + + +L + R+ E+ +L ++ Sbjct: 54 RYEIRHLIGTGSYGHVCEAYDKLEKRVVAIKKI----LRVFEDLIDCKRILREIAILNRL 109 Query: 97 SSGFSGVIRLLDWF-----ERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQV 151 + V+++LD E+ D ++LE + D L E ++ + + Sbjct: 110 NHDH--VVKVLDIVIPKDVEKFDELYVVLEIAD--SDFKKLFRTPVYLTELHIKTLLYNL 165 Query: 152 LEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDG-------- 203 L V++ H+ G+LHRD+K N L++ + +K+ DFG L TV +G Sbjct: 166 LVGVKYVHSAGILHRDLKPANCLVNQD-CSVKVCDFG----LARTVDYPENGNSQLPISP 220 Query: 204 -------------------------TRVYSPPEWIRYHRYHGRSAAVWSLGIL---LYDM 235 TR Y PE I + + VWS+G + L +M Sbjct: 221 REDDMNLVTFPHTKNLKRQLTGHVVTRWYRAPELILLQENYTEAIDVWSIGCIFAELLNM 280 Query: 236 VCGDIPFEHDEEIIRGQVF 254 + ++ + D RG +F Sbjct: 281 IKENVAYHAD----RGPLF 295 >4UYA-A nrPDB Length = 340 Score = 54.7 bits (130), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 52/219 (23%), Positives = 86/219 (39%), Gaps = 37/219 (16%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 L+G+GGFG VY VA+K +D D R + + + Sbjct: 33 LIGAGGFGQVYRATWQGQE--VAVKAARQDPEQDAAAAAESVRREARLFAMLR----HPN 86 Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELAR---------SFFWQVLE 153 +I L + L+LE GAL LA ++ Q+ Sbjct: 87 IIELRGVCLQQPHLCLVLE-----------FARGGALNRALAGRRIPPHVLVNWAVQIAR 135 Query: 154 AVRHCHN---CGVLHRDIKDENILI-------DLNRGELKLIDFGSGALLKDTVYTDFDG 203 + + H +LHRD+K NIL+ D+ LK+ DFG T G Sbjct: 136 GMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMATAG 195 Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF 242 + PE I+ + + + +WS G+LL++++ G++P+ Sbjct: 196 AYAWMAPEVIKSSLF-SKGSDIWSYGVLLWELLTGEVPY 233 >4TN6-A nrPDB Length = 318 Score = 54.3 bits (129), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 67/279 (24%), Positives = 126/279 (45%), Gaps = 44/279 (15%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 ++Y++G +GSG FG +Y G ++ VAIK +E + ++ +E + K Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIK-LECVKTKH-------PQLHIESKIYKM 58 Query: 96 VSSGFSGVIRLLDWF-ERPDSFVLILERPEP-VQDLFDFITERGALQEELARSFFWQVLE 153 + G I + W D V+++E P ++DLF+F + + +L+ L + Q++ Sbjct: 59 MQGGVG--IPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLA--DQMIS 114 Query: 154 AVRHCHNCGVLHRDIKDENILIDL-NRGEL-KLIDFGSGALLKDTVY---------TDFD 202 + + H+ +HRD+K +N L+ L +G L +IDFG +D + Sbjct: 115 RIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLT 174 Query: 203 GTRVYSPPEWIRYHR--YHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR---Q 257 GT Y+ I H R + SLG +L G +P++ + + Q + R + Sbjct: 175 GTARYAS---INTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEK 231 Query: 258 RVS-----------SECQHLIRWCLALRPSDRPTFEEIQ 285 ++S SE + +C +LR D+P + ++ Sbjct: 232 KMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLR 270 >2VD5-A nrPDB Length = 412 Score = 54.3 bits (129), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 41/128 (32%), Positives = 65/128 (50%), Gaps = 11/128 (8%) Query: 128 DLFDFITERGA-LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLID 186 DL +++ G + E+AR + +++ A+ H G +HRDIK +NIL+D G ++L D Sbjct: 147 DLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLD-RCGHIRLAD 205 Query: 187 FGSGALLK--DTVYTDFD-GTRVYSPPEWIRYHRYHGRSAAV------WSLGILLYDMVC 237 FGS L+ TV + GT Y PE ++ + + W+LG+ Y+M Sbjct: 206 FGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFY 265 Query: 238 GDIPFEHD 245 G PF D Sbjct: 266 GQTPFYAD 273 >4P5Q-A nrPDB Length = 361 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 68/283 (24%), Positives = 123/283 (43%), Gaps = 51/283 (18%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSG---IRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 KE + + ++G+G FG V SG + + VAIK Sbjct: 28 KELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIK-------------------T 68 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVL--ILERPEPVQDLFDFITERGALQEELAR 145 ++V +K F G ++ F+ P+ L ++ + +PV + +++ E G+L L + Sbjct: 69 LKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYM-ENGSLDSFLRK 127 Query: 146 -----------SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK 194 + +++ + G +HRD+ NILI+ N K+ DFG +L+ Sbjct: 128 HDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILINSNL-VCKVSDFGLSRVLE 186 Query: 195 D---TVYTDFDGT--RVYSPPEWIRYHRYHGRSAAVWSLGILLYD-MVCGDIPF--EHDE 246 D YT G ++ PE I Y ++ S VWS GI+L++ M G+ P+ ++ Sbjct: 187 DDPEAAYTTRGGKIPIRWTSPEAIAYRKFTSAS-DVWSYGIVLWEVMSYGERPYWEMSNQ 245 Query: 247 EIIRG-QVFFRQRVSSEC----QHLIRWCLALRPSDRPTFEEI 284 ++I+ +R +C L+ C ++RP FE+I Sbjct: 246 DVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQI 288 >4CRL-A nrPDB Length = 406 Score = 53.5 bits (127), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 61/251 (24%), Positives = 105/251 (41%), Gaps = 38/251 (15%) Query: 24 KLAPGKEKEPLESQYQV-GPLLGSGGFGSVYSGIRVSDNLP--VAIKHVEKDRISDWG-- 78 K+ E+E +E ++ G +G G +G VY R A+K +E IS Sbjct: 9 KVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACR 68 Query: 79 ------ELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERP-----EPVQ 127 EL + + ++ V L S V L D+ E ++ R +PVQ Sbjct: 69 EIALLRELKHPNVISLQKVFL---SHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQ 125 Query: 128 DLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILI---DLNRGELKL 184 L + +S +Q+L+ + + H VLHRD+K NIL+ RG +K+ Sbjct: 126 -----------LPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKI 174 Query: 185 IDFGSGALLKDTV--YTDFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGD 239 D G L + D D V Y PE + R++ ++ +W++G + +++ + Sbjct: 175 ADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSE 234 Query: 240 IPFEHDEEIIR 250 F +E I+ Sbjct: 235 PIFHCRQEDIK 245 >6CKI-A nrPDB Length = 316 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 77/301 (25%), Positives = 122/301 (40%), Gaps = 53/301 (17%) Query: 34 LESQYQVGP-LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVL 92 E YQ+ +LG G V + I + + A+K +EK G + +RV EV + Sbjct: 10 FEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQP----GHIR--SRVFREVEM 63 Query: 93 LKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 L + G V+ L+++FE D F L+ E+ + I +R E A V Sbjct: 64 LYQCQ-GHRNVLELIEFFEEEDRFYLVFEKMRG-GSILSHIHKRRHFNELEASVVVQDVA 121 Query: 153 EAVRHCHNCGVLHRDIKDENILID--LNRGELKLIDFGSGALLKDTVYTDFD-------- 202 A+ HN G+ HRD+K ENIL + +K+ DFG G+ +K + D Sbjct: 122 SALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIK--LNGDCSPISTPELL 179 Query: 203 ---GTRVYSPPEWIRYH----RYHGRSAAVWSLGILLYDMVCGDIPFEHD---------- 245 G+ Y PE + + + +WSLG++LY ++ G PF Sbjct: 180 TPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRG 239 Query: 246 -----------EEIIRGQVFFRQR----VSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 E I G+ F + +S + LI L R + ++ HPW+ Sbjct: 240 EACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV 299 Query: 291 Q 291 Q Sbjct: 300 Q 300 >3BBT-B nrPDB Length = 328 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 55/222 (24%), Positives = 106/222 (47%), Gaps = 27/222 (12%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSD----NLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 E++ + +LGSG FG+VY GI V + +PVAIK + + G + +E Sbjct: 14 ETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNET---------TGPKANVEF 64 Query: 91 V--LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSF 147 + L S ++RLL P + ++ + P L +++ E + + +L ++ Sbjct: 65 MDEALIMASMDHPHLVRLLGVCLSPT--IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNW 122 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRV 206 Q+ + + + ++HRD+ N+L+ + +K+ DFG LL+ D + DG ++ Sbjct: 123 CVQIAKGMMYLEERRLVHRDLAARNVLVK-SPNHVKITDFGLARLLEGDEKEYNADGGKM 181 Query: 207 YSPPEWIRYHRYHGRS----AAVWSLGILLYD-MVCGDIPFE 243 P +W+ H R + VWS G+ +++ M G P++ Sbjct: 182 --PIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYD 221 >1AD5-A nrPDB Length = 438 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 48/171 (28%), Positives = 80/171 (46%), Gaps = 25/171 (14%) Query: 129 LFDFITERGALQEELAR--SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLID 186 L DF+ ++ L + F Q+ E + +HRD++ NIL+ + K+ D Sbjct: 263 LLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASL-VCKIAD 321 Query: 187 FGSGALLKDTVYTDFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF 242 FG + G + ++ PE I + + +S VWS GILL ++V G IP+ Sbjct: 322 FGLARV----------GAKFPIKWTAPEAINFGSFTIKSD-VWSFGILLMEIVTYGRIPY 370 Query: 243 E--HDEEIIRG-QVFFR----QRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 + E+IR + +R + E +++ C RP +RPTFE IQ+ Sbjct: 371 PGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQS 421 >5GNK-A nrPDB Length = 297 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 53/221 (23%), Positives = 106/221 (47%), Gaps = 25/221 (11%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSD----NLPVAIKHVEKDRISDWGELPNGTRVPM-E 89 E++++ +LGSG FG+VY G+ + + +PVAIK + + P + + E Sbjct: 18 ETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRE------ATSPKANKEILDE 71 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSFF 148 ++ V + V RLL S V ++ + P L D++ E + + + ++ Sbjct: 72 AYVMASVDN--PHVCRLLGIC--LTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWC 127 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL-KDTVYTDFDGTRVY 207 Q+ + + + + ++HRD+ N+L+ + +K+ DFG LL + +G +V Sbjct: 128 VQIAKGMNYLEDRRLVHRDLAARNVLVKTPQ-HVKITDFGLAKLLGAEEKEYHAEGGKV- 185 Query: 208 SPPEWIR----YHRYHGRSAAVWSLGILLYD-MVCGDIPFE 243 P +W+ HR + + VWS G+ +++ M G P++ Sbjct: 186 -PIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYD 225 >4IDT-A nrPDB Length = 356 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 54/220 (24%), Positives = 87/220 (39%), Gaps = 25/220 (11%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 LG G FG V+ A+K V + + +V L G Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPL-------YGA 134 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGV 163 +R W + F+ +LE L + E+G L E+ A + Q LE + + H+ + Sbjct: 135 VREGPWV---NIFMELLEG----GSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRI 187 Query: 164 LHRDIKDENILIDLNRGELKLIDFGSGALL------KDTVYTDF-DGTRVYSPPEWIRYH 216 LH D+K +N+L+ + L DFG L KD + D+ GT + PE + Sbjct: 188 LHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVV-LG 246 Query: 217 RYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR 256 R VWS ++ M+ G P+ + RG + + Sbjct: 247 RSCDAKVDVWSSCCMMLHMLNGCHPW---TQFFRGPLCLK 283 >2W96-B nrPDB Length = 306 Score = 52.0 bits (123), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 59/210 (28%), Positives = 94/210 (44%), Gaps = 19/210 (9%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGE-LPNGTRVPMEVVLLK 94 S+Y+ +G G +G+VY VA+K V R+ + E LP T EV LL+ Sbjct: 4 SRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSV---RVPNGEEGLPISTV--REVALLR 58 Query: 95 KVSS-GFSGVIRLLDW-----FERPDSFVLILERPEPVQDLFDFITERG--ALQEELARS 146 ++ + V+RL+D +R L+ E + QDL ++ + L E + Sbjct: 59 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD--QDLRTYLDKAPPPGLPAETIKD 116 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTD-FDGTR 205 Q L + H ++HRD+K ENIL+ + G +KL DFG + + D T Sbjct: 117 LMRQFLRGLDFLHANCIVHRDLKPENILVT-SGGTVKLADFGLARIYSYQMALDPVVVTL 175 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDM 235 Y PE + Y +WS+G + +M Sbjct: 176 WYRAPEVLLQSTY-ATPVDMWSVGCIFAEM 204 >4OTD-A nrPDB Length = 341 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 75/279 (26%), Positives = 127/279 (45%), Gaps = 24/279 (8%) Query: 31 KEPLE-SQYQVGPLLGSGGFGSVY-SGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 K PL ++ +LG G FG V S R S L AIK ++K I E+ + + Sbjct: 6 KSPLTLEDFKFLAVLGRGHFGKVLLSEFRPSGEL-FAIKALKKGDIVARDEVE--SLMCE 62 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 148 + +L S+G ++ L F+ P+ ++E DL I E A + Sbjct: 63 KRILAAVTSAGHPFLVNLFGCFQTPEHVCFVMEY-SAGGDLMLHI-HSDVFSEPRAIFYS 120 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG---SGALLKDTVYTDFDGTR 205 V+ ++ H +++RD+K +N+L+ G +K+ DFG G D T F GT Sbjct: 121 ACVVLGLQFLHEHKIVYRDLKLDNLLL-DTEGYVKIADFGLCKEGMGYGDRTST-FCGTP 178 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRV 259 + PE + Y R+ W LG+LLY+M+ G+ PF D+E I+ +V + + + Sbjct: 179 EFLAPEVLTDTSYT-RAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFL 237 Query: 260 SSECQHLIRWCLALRP-----SDRPTFEEIQNHPWMQDV 293 S+E ++R L P S E+++ P+ + + Sbjct: 238 SAEAIGIMRRLLRRNPERRLGSSERDAEDVKKQPFFRTL 276 >3RAW-A nrPDB Length = 381 Score = 51.6 bits (122), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 61/239 (25%), Positives = 98/239 (41%), Gaps = 38/239 (15%) Query: 34 LESQYQVGPLLGSGGFGSVYSGI-RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVL 92 L+ +Y++ LG G FG V + VA+K I + G+ R +E+ + Sbjct: 49 LQERYEIVGNLGEGTFGKVVECLDHARGKSQVALK-----IIRNVGKYREAAR--LEINV 101 Query: 93 LKKVS-----SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEEL--AR 145 LKK+ + F V+ + DWF + E ++ F+F+ E L R Sbjct: 102 LKKIKEKDKENKFLCVL-MSDWFNFHGHMCIAFELLG--KNTFEFLKENNFQPYPLPHVR 158 Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILI------------------DLNRGELKLIDF 187 +Q+ A+R H + H D+K ENIL + +++ DF Sbjct: 159 HMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADF 218 Query: 188 GSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE 246 GS A +T TR Y PPE I + + VWS+G +L++ G F+ E Sbjct: 219 GS-ATFDHEHHTTIVATRHYRPPEVILELGW-AQPCDVWSIGCILFEYYRGFTLFQTHE 275 >5UNP-A nrPDB Length = 369 Score = 51.6 bits (122), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 60/244 (24%), Positives = 107/244 (43%), Gaps = 49/244 (20%) Query: 34 LESQYQVGPLLGSGGFGSVYS-------GIRVSDNLPVAIKHVEKDRISDWGELPNGTRV 86 L+ +Y++ LG G FG V G RV+ + IK+VEK + + Sbjct: 32 LQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKI---IKNVEKYKEA----------A 78 Query: 87 PMEVVLLKKVSS----GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEE 142 +E+ +L+K++ + +++ DWF+ + E FDF+ + L Sbjct: 79 RLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLG--LSTFDFLKDNNYLPYP 136 Query: 143 L--ARSFFWQVLEAVRHCHNCGVLHRDIKDENIL-----------IDLNRGE-------L 182 + R +Q+ +AV+ H+ + H D+K ENIL ++ R E + Sbjct: 137 IHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAV 196 Query: 183 KLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF 242 +++DFGS A ++ TR Y PE I + + VWS+G ++++ G F Sbjct: 197 RVVDFGS-ATFDHEHHSTIVSTRHYRAPEVILELGW-SQPCDVWSIGCIIFEYYVGFTLF 254 Query: 243 E-HD 245 + HD Sbjct: 255 QTHD 258 >4GS6-A nrPDB Length = 315 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 67/267 (25%), Positives = 116/267 (43%), Gaps = 40/267 (14%) Query: 37 QYQVGPLLGSGGFGSVYSGI-RVSDNLPVAIKHVEKD--RISDWGELPNGTRVPMEVVLL 93 + +V ++G G FG V R D VAIK +E + R + EL +RV ++ Sbjct: 10 EIEVEEVVGRGAFGVVCKAKWRAKD---VAIKQIESESERKAFIVELRQLSRVNHPNIV- 65 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 K + + V ++++ E S +L EP+ + T A+ S+ Q + Sbjct: 66 KLYGACLNPVCLVMEYAEG-GSLYNVLHGAEPL----PYYTAAHAM------SWCLQCSQ 114 Query: 154 AVRHCHNC---GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPP 210 V + H+ ++HRD+K N+L+ LK+ DFG+ ++ T T+ G+ + P Sbjct: 115 GVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ-THMTNNKGSAAWMAP 173 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVF-------------FRQ 257 E Y V+S GI+L++++ PF+ I G F + Sbjct: 174 EVFEGSNY-SEKCDVFSWGIILWEVITRRKPFDE----IGGPAFRIMWAVHNGTRPPLIK 228 Query: 258 RVSSECQHLIRWCLALRPSDRPTFEEI 284 + + L+ C + PS RP+ EEI Sbjct: 229 NLPKPIESLMTRCWSKDPSQRPSMEEI 255 >4Y83-A nrPDB Length = 332 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 44/153 (28%), Positives = 65/153 (42%), Gaps = 18/153 (11%) Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY--TDFDGTRVY 207 VL+ + H+ V+H DIK NI+ + L+DFG + + VY D GT +Y Sbjct: 173 HVLKGLDFLHSKKVIHHDIKPSNIVFMSTKA--VLVDFGLSVQMTEDVYFPKDLRGTEIY 230 Query: 208 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIP---------FEHDEEIIRGQVFFRQR 258 PE I R H A ++SLG L M G P + II Q + Sbjct: 231 MSPEVI-LCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLED 289 Query: 259 VSSEC----QHLIRWCLALRPSDRPTFEEIQNH 287 ++ +C + LI L P+ RP ++ H Sbjct: 290 IADDCSPGMRELIEASLERNPNHRPRAADLLKH 322 >5AMN-A nrPDB Length = 299 Score = 51.2 bits (121), Expect = 6e-07, Method: Compositional matrix adjust. Identities = 42/154 (27%), Positives = 73/154 (47%), Gaps = 16/154 (10%) Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDGT 204 SF WQ+ + +++ ++HRD+ NIL+ R ++K+ DFG S + ++ Y Sbjct: 140 SFAWQISQGMQYLAEMKLVHRDLAARNILVAEGR-KMKISDFGLSRDVYEEDSYVKRSQG 198 Query: 205 RVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVC--GD----IPFEHDEEIIR-GQV 253 R+ P +W+ + + + VWS G+LL+++V G+ IP E +++ G Sbjct: 199 RI--PVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHR 256 Query: 254 FFR-QRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 R S E L+ C P RP F +I Sbjct: 257 MERPDNCSEEMYRLMLQCWKQEPDKRPVFADISK 290 >5FM2-A nrPDB Length = 355 Score = 50.8 bits (120), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 42/154 (27%), Positives = 73/154 (47%), Gaps = 16/154 (10%) Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDGT 204 SF WQ+ + +++ ++HRD+ NIL+ R ++K+ DFG S + ++ Y Sbjct: 195 SFAWQISQGMQYLAEMKLVHRDLAARNILVAEGR-KMKISDFGLSRDVYEEDSYVKRSQG 253 Query: 205 RVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVC--GD----IPFEHDEEIIR-GQV 253 R+ P +W+ + + + VWS G+LL+++V G+ IP E +++ G Sbjct: 254 RI--PVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHR 311 Query: 254 FFR-QRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 R S E L+ C P RP F +I Sbjct: 312 MERPDNCSEEMYRLMLQCWKQEPDKRPVFADISK 345 >4XHH-A nrPDB Length = 403 Score = 50.8 bits (120), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 44/163 (26%), Positives = 82/163 (50%), Gaps = 16/163 (9%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 ++++G +GSG FG +Y G + VAI+ +E R S +L +RV K + Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAIR-LESIR-SRHPQLDYESRV------YKYL 59 Query: 97 SSGFSGVIRLLDWFERPDSF-VLILERPEP-VQDLFDFITERGALQEELARSFFWQVLEA 154 S G I + WF R + ++++ P ++DLF++ + + + + + Q++ Sbjct: 60 SGGVG--IPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRKFSFKTVIMLAL--QMICR 115 Query: 155 VRHCHNCGVLHRDIKDENILIDLNR--GELKLIDFGSGALLKD 195 V++ H +HRDIK +N L+ + R + +IDFG +D Sbjct: 116 VQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRD 158 >4BTK-A nrPDB Length = 337 Score = 50.8 bits (120), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 57/221 (25%), Positives = 95/221 (42%), Gaps = 25/221 (11%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 ++ +++V +G GGFG +Y + + VA+K VE + P + MEV +L Sbjct: 54 VKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-VES------AQQPKQV-LKMEVAVL 105 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE--RGALQEELARSFFWQV 151 KK+ G V R + R + F ++ + + ++L D RG Q+ Sbjct: 106 KKLQ-GKDHVCRFIGC-GRNEKFNYVVMQLQG-RNLADLRRSQPRGTFTLSTTLRLGKQI 162 Query: 152 LEAVRHCHNCGVLHRDIKDENILIDL---NRGELKLIDFGSGALLKDTV--------YTD 200 LE++ H+ G LHRDIK N + + ++DFG +T Sbjct: 163 LESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAG 222 Query: 201 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIP 241 F GT Y+ + +R GR +WSL +L + G +P Sbjct: 223 FRGTVRYASVNAHK-NREMGRHDDLWSLFYMLVEFAVGQLP 262 >4EBW-A nrPDB Length = 304 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 67/263 (25%), Positives = 120/263 (45%), Gaps = 28/263 (10%) Query: 39 QVGPLLGSGGFGSVYSGIRVSDNLP---VAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 ++G +G G FG V+ GI +S P VAIK K+ SD + E + +++ Sbjct: 41 ELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTC-KNCTSD----SVREKFLQEALTMRQ 95 Query: 96 VSSGFSGVIRLLDWF-ERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQVLE 153 +++L+ E P V I+ + +L F+ R +L + +Q+ Sbjct: 96 FDH--PHIVKLIGVITENP---VWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLST 150 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---YSPP 210 A+ + + +HRDI N+L+ N +KL DFG ++D+ Y ++ + P Sbjct: 151 ALAYLESKRFVHRDIAARNVLVSSNDC-VKLGDFGLSRYMEDSTYYKASKGKLPIKWMAP 209 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFE---HDEEIIRGQVFFRQRVSSEC--- 263 E I + R+ S VW G+ +++++ G PF+ +++ I R + R + C Sbjct: 210 ESINFRRFTSAS-DVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPT 268 Query: 264 -QHLIRWCLALRPSDRPTFEEIQ 285 L+ C A PS RP F E++ Sbjct: 269 LYSLMTKCWAYDPSRRPRFTELK 291 >4NFN-A nrPDB Length = 309 Score = 50.4 bits (119), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 55/222 (24%), Positives = 95/222 (42%), Gaps = 25/222 (11%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 ++ +++V +G GGFG +Y + + VA+K + + P + MEV +L Sbjct: 19 VKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALK-------VESAQQPKQV-LKMEVAVL 70 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE--RGALQEELARSFFWQV 151 KK+ G V R + R + F ++ + + ++L D RG Q+ Sbjct: 71 KKLQ-GKDHVCRFIGC-GRNEKFNYVVMQLQG-RNLADLRRSQPRGTFTLSTTLRLGKQI 127 Query: 152 LEAVRHCHNCGVLHRDIKDENILIDL---NRGELKLIDFGSGALLKDTV--------YTD 200 LE++ H+ G LHRDIK N + + ++DFG +T Sbjct: 128 LESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAG 187 Query: 201 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF 242 F GT Y+ + +R GR +WSL +L + G +P+ Sbjct: 188 FRGTVRYASVNAHK-NREMGRHDDLWSLFYMLVEFAVGQLPW 228 >4F9B-A nrPDB Length = 361 Score = 50.4 bits (119), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 51/244 (20%), Positives = 96/244 (39%), Gaps = 50/244 (20%) Query: 34 LESQYQVGPLLGSGGFGSVY---SGIRVSDNLPVAIKHVEKDRISDWGELPNG--TRVPM 88 L + +++ +G G F SVY + ++V +A+KH+ +P R+ Sbjct: 19 LSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHL----------IPTSHPIRIAA 68 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 148 E+ L V+ G V+ + F + D V+ + P + F+ +L + R + Sbjct: 69 ELQCLT-VAGGQDNVMGVKYCFRKNDHVVIAM----PYLEHESFLDILNSLSFQEVREYM 123 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-------VYTDF 201 + +A++ H G++HRD+K N L + + L+DFG DT V ++ Sbjct: 124 LNLFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEA 183 Query: 202 D-----------------------GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCG 238 GT + PE + + +WS G++ ++ G Sbjct: 184 QQERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSG 243 Query: 239 DIPF 242 PF Sbjct: 244 RYPF 247 >3QD2-B nrPDB Length = 332 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 44/181 (24%), Positives = 87/181 (48%), Gaps = 26/181 (14%) Query: 127 QDLFDFITERGALQEE---LARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELK 183 ++L D++ R +L++ + F Q+ EAV H+ G++HRD+K NI ++ +K Sbjct: 146 ENLKDWMNRRCSLEDREHGVCLHIFIQIAEAVEFLHSKGLMHRDLKPSNIFFTMD-DVVK 204 Query: 184 LIDFG-SGALLKD-------------TVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLG 229 + DFG A+ +D +T GT++Y PE I + Y ++SLG Sbjct: 205 VGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQVGTKLYMSPEQIHGNNY-SHKVDIFSLG 263 Query: 230 ILLYDMVCG------DIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEE 283 ++L++++ + D ++ + F Q+ E +++ L+ P++RP + Sbjct: 264 LILFELLYSFSTQMERVRIITDVRNLKFPLLFTQKYPQE-HMMVQDMLSPSPTERPEATD 322 Query: 284 I 284 I Sbjct: 323 I 323 >4MWI-A nrPDB Length = 294 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 66/243 (27%), Positives = 105/243 (43%), Gaps = 47/243 (19%) Query: 85 RVPMEVVLLKKVSSG--------FSGVIRLLDWFERPDSF----VLILERPEPVQDLFDF 132 R P+ + + KK+ +G F+ I+ + FE P+ + I E P Q F Sbjct: 47 RAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQ--FSI 104 Query: 133 ITER---GALQEELAR-------SFFWQVLEAVR-----HCHNCGVLHRDIKDENILIDL 177 + E G L+E L R VL A R H LH I+ N L+ Sbjct: 105 VMEYCELGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQ 164 Query: 178 NRGELKLIDF------GSGALLKDTVYTDFDGTRVYSPPEWIR--YHRYHGRSAAVWSLG 229 ++KL F S +L TD + Y P+ + +++Y +S ++S G Sbjct: 165 GY-QVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSE-IYSFG 222 Query: 230 ILLYDMVCGDIPFEH-DEEIIRGQVFFRQR-------VSSECQHLIRWCLALRPSDRPTF 281 I+L+++ GDIPF+ + E IR V +++ SE + +I C A PS RP+ Sbjct: 223 IVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSV 282 Query: 282 EEI 284 +EI Sbjct: 283 DEI 285 >4LQP-A nrPDB Length = 508 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 43/146 (29%), Positives = 67/146 (45%), Gaps = 7/146 (4%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 ++G G FG V + A+K + K + +L + V E +L S + Sbjct: 109 VIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAH---VKAERDVLAGSDSPW-- 163 Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCG 162 V+ L F+ LI+E P DL + E++ R + + + A+ H G Sbjct: 164 VVSLYYSFQDAQYLYLIMEFL-PGGDLMTMLIRWQLFTEDVTRFYMAECILAIETIHKLG 222 Query: 163 VLHRDIKDENILIDLNRGELKLIDFG 188 +HR IK +NILID+ RG +KL DFG Sbjct: 223 FIHRAIKPDNILIDI-RGHIKLSDFG 247 Score = 37.0 bits (84), Expect = 0.011, Method: Compositional matrix adjust. Identities = 33/104 (31%), Positives = 47/104 (45%), Gaps = 14/104 (13%) Query: 203 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHDEEIIRGQVFFRQ--- 257 GT Y PE Y Y G+ WSLG ++Y+ + G PF E +E R + F Q Sbjct: 325 GTPDYIAPEIFLYQGY-GQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQ 383 Query: 258 -----RVSSECQHLIRWCLA---LRPSDRPTFEEIQNHPWMQDV 293 +S E + LIR L R +EI++HP+ + V Sbjct: 384 FPDDIHISYEAEDLIRRLLTHADQRLGRHGGADEIKSHPFFRGV 427 >6DBM-A nrPDB Length = 318 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 41/165 (24%), Positives = 76/165 (46%), Gaps = 29/165 (17%) Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-----TVYTDF 201 F Q+ E + + H+ +HRD+ N+L+D +R +K+ DFG + + V D Sbjct: 139 FAQQICEGMAYLHSQHYIHRDLAARNVLLDNDR-LVKIGDFGLAKAVPEGHEYYRVREDG 197 Query: 202 DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC--------------------GDIP 241 D + PE ++ ++++ ++ VWS G+ LY+++ G + Sbjct: 198 DSPVFWYAPECLKEYKFY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMT 256 Query: 242 FEHDEEII-RGQVFFR-QRVSSECQHLIRWCLALRPSDRPTFEEI 284 E++ RG+ R + +E HL++ C S RPTFE + Sbjct: 257 VLRLTELLERGERLPRPDKCPAEVYHLMKNCWETEASFRPTFENL 301 >1CSN-A nrPDB Length = 298 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 44/165 (26%), Positives = 80/165 (48%), Gaps = 16/165 (9%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 Y+VG +G G FG ++ G + +N VAIK + R SD +L + R K+ Sbjct: 12 YKVGRRIGEGSFGVIFEGTNLLNNQQVAIKF--EPRRSDAPQLRDEYRT-------YKLL 62 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITERGALQEELARSFFWQVLEAVR 156 +G +G+ + + + VL+++ P ++DL D + +++ + Q+L V+ Sbjct: 63 AGCTGIPNVYYFGQEGLHNVLVIDLLGPSLEDLLDLCGRKFSVKTVAMAA--KQMLARVQ 120 Query: 157 HCHNCGVLHRDIKDENILI----DLNRGELKLIDFGSGALLKDTV 197 H +++RDIK +N LI N + ++DFG +D V Sbjct: 121 SIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPV 165 >5HLW-A nrPDB Length = 299 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 54/226 (23%), Positives = 104/226 (46%), Gaps = 21/226 (9%) Query: 43 LLGSGGFGSVYSGIRVSDN---LPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 99 ++G G FG VY G + ++ + A+K + +RI+D GE+ ++ E +++K S Sbjct: 27 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSL--NRITDIGEV---SQFLTEGIIMKDFSH- 80 Query: 100 FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI---TERGALQEELARSFFWQVLEAVR 156 V+ LL R + L++ DL +FI T +++ + F QV + ++ Sbjct: 81 -PNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIG--FGLQVAKGMK 137 Query: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-VYTDFDGTRVYSPPEWIRY 215 + + +HRD+ N ++D + +K+ DFG + D Y+ + T P +W+ Sbjct: 138 YLASKKFVHRDLAARNCMLD-EKFTVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMAL 196 Query: 216 HRYHGRS----AAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ 257 + + VWS G+LL++++ P D V+ Q Sbjct: 197 ESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQ 242 >4XHL-A nrPDB Length = 394 Score = 50.1 bits (118), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 43/163 (26%), Positives = 81/163 (49%), Gaps = 16/163 (9%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 ++++G +GSG FG +Y G + VAI+ +E R S +L +RV + + Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAIR-LESIR-SRHPQLDYESRV------YRYL 59 Query: 97 SSGFSGVIRLLDWFERPDSF-VLILERPEP-VQDLFDFITERGALQEELARSFFWQVLEA 154 S G I + WF R + ++++ P ++DLF++ R + + + + Q+ Sbjct: 60 SGGVG--IPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLAL--QMFCR 115 Query: 155 VRHCHNCGVLHRDIKDENILIDLNR--GELKLIDFGSGALLKD 195 +++ H +HRDIK +N L+ + R + +IDFG +D Sbjct: 116 IQYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRD 158 >4JRN-A nrPDB Length = 372 Score = 49.7 bits (117), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 61/239 (25%), Positives = 99/239 (41%), Gaps = 41/239 (17%) Query: 41 GPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTR--------------- 85 G LGSGGF +VY V N +A+K ++ + + R Sbjct: 73 GAPLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAK 132 Query: 86 ---------VPMEVVLLKKVSSGFSGVIRLLD-WFERPDSFVLILERPEPVQDLFDFITE 135 VP +VV+L+ + VI L W P+ F+L++ + + ++ Sbjct: 133 DAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWV--PNYFLLMMRAEADMSKVISWVFG 190 Query: 136 RGALQEE----LARSFFW-QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSG 190 ++ + + R + Q ++ V + G++H DIK N L+ L G L L DFG+ Sbjct: 191 DASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLL-LKDGRLFLGDFGT- 248 Query: 191 ALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAA----VWSLGILLYDMVCGDIPFEHD 245 + ++V GT Y PPE R + G + W LGI LY + C + P D Sbjct: 249 YRINNSVGRAI-GTPGYEPPE--RPFQATGITYTFPTDAWQLGITLYCIWCKERPTPAD 304 >1LUF-A nrPDB Length = 343 Score = 49.7 bits (117), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 43/148 (29%), Positives = 68/148 (45%), Gaps = 14/148 (9%) Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV--- 206 QV + + +HRD+ N L+ N +K+ DFG + Y DG Sbjct: 182 QVAAGMAYLSERKFVHRDLATRNCLVGENM-VVKIADFGLSRNIYSADYYKADGNDAIPI 240 Query: 207 -YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF---EHDEEIIR---GQVF-FRQ 257 + PPE I Y+RY S VW+ G++L+++ G P+ H+E I G + + Sbjct: 241 RWMPPESIFYNRYTTESD-VWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPE 299 Query: 258 RVSSECQHLIRWCLALRPSDRPTFEEIQ 285 E +L+R C + P+DRP+F I Sbjct: 300 NCPLELYNLMRLCWSKLPADRPSFCSIH 327 >6GQK-A nrPDB Length = 328 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 75/285 (26%), Positives = 120/285 (42%), Gaps = 57/285 (20%) Query: 41 GPLLGSGGFGSVYSG-----IRVSDNLPVAIKHVEKDRISDWGE-----------LPNGT 84 G LG+G FG V I+ + VA+K ++ S E L N Sbjct: 46 GKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAHSTEREALMSELKVLSYLGNHE 105 Query: 85 RVPMEVVLLKKVSSGFSGVI--------RLLDWFERP-DSFVLILERPEPVQDLF-DFIT 134 + V LL + G ++ LL++ R D FV PE DL+ DF+T Sbjct: 106 NI---VNLLGACTHGGPTLVITEYCCYGDLLNFLRRKRDEFVPYKVAPE---DLYKDFLT 159 Query: 135 ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL-KLIDFGSGALL 193 L SF +QV + + + +HRD+ NIL L G + K+ DFG + Sbjct: 160 LEHLL------SFSYQVAKGMAFLASKNCIHRDLAARNIL--LTHGNITKICDFGLARDI 211 Query: 194 K-DTVYTDFDGTRVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVC-GDIPFEH--- 244 K D+ Y D R+ P +W+ ++ + + VWS GI L+++ G P+ Sbjct: 212 KNDSNYVDKGNARL--PVKWMAPESIFNSVYTFESDVWSYGIFLWELFSLGSSPYPGMPV 269 Query: 245 DEEIIRG-QVFFR----QRVSSECQHLIRWCLALRPSDRPTFEEI 284 D + + + FR + +E +++ C P RPTF++I Sbjct: 270 DSKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQI 314 >3CJF-A nrPDB Length = 309 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 53/180 (29%), Positives = 83/180 (46%), Gaps = 28/180 (15%) Query: 125 PVQDLF-DFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELK 183 P +DL+ DF+T L+ + SF QV + + + +HRD+ NIL+ + +K Sbjct: 132 PYKDLYKDFLT----LEHLICYSF--QVAKGMEFLASRKCIHRDLAARNILLS-EKNVVK 184 Query: 184 LIDFGSGALLKDTVYTDFDGTR---VYSPPEWIR----YHRYHGRSAAVWSLGILLYDMV 236 + DFG L +Y D D R P +W+ + R + + VWS G+LL+++ Sbjct: 185 ICDFG----LARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIF 240 Query: 237 C-GDIPF---EHDEEIIRG-QVFFRQR----VSSECQHLIRWCLALRPSDRPTFEEIQNH 287 G P+ + DEE R + R R + E + C PS RPTF E+ H Sbjct: 241 SLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEH 300 >3PPZ-A nrPDB Length = 309 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 57/279 (20%), Positives = 124/279 (44%), Gaps = 34/279 (12%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAI---KHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGF 100 +G+G FG+V+ ++ V I + +R++++ EV ++K++ Sbjct: 45 IGAGSFGTVHRAEWHGSDVAVKILMEQDFHAERVNEFLR---------EVAIMKRLR--H 93 Query: 101 SGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA---LQEELARSFFWQVLEAVRH 157 ++ + +P + ++ E L+ + + GA L E S + V + + + Sbjct: 94 PNIVLFMGAVTQPPNLSIVTEYLS-RGSLYRLLHKSGAREQLDERRRLSMAYDVAKGMNY 152 Query: 158 CHNCG--VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD--GTRVYSPPEWI 213 HN ++HRD+K N+L+D + +K+ DFG L T + GT + PE + Sbjct: 153 LHNRNPPIVHRDLKSPNLLVD-KKYTVKVCDFGLSRLKASTFLSSKSAAGTPEWMAPEVL 211 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEH-DEEIIRGQVFFR-------QRVSSECQH 265 R + +S V+S G++L+++ P+ + + + V F+ + ++ + Sbjct: 212 RDEPSNEKS-DVYSFGVILWELATLQQPWGNLNPAQVVAAVGFKCKRLEIPRNLNPQVAA 270 Query: 266 LIRWCLALRPSDRPTFEEIQN--HPWMQDVLLPQETAEI 302 +I C P RP+F I + P ++ + P +++ Sbjct: 271 IIEGCWTNEPWKRPSFATIMDLLRPLIKSAVPPPNRSDL 309 >3VHK-A nrPDB Length = 368 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 54/185 (29%), Positives = 85/185 (45%), Gaps = 28/185 (15%) Query: 120 LERPEPVQDLF-DFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLN 178 +E E +DL+ DF+T L+ + SF QV + + + +HRD+ NIL+ Sbjct: 183 VEEEEAPEDLYKDFLT----LEHLICYSF--QVAKGMEFLASRKCIHRDLAARNILLS-E 235 Query: 179 RGELKLIDFGSGALLKDTVYTDFDGTR---VYSPPEWIR----YHRYHGRSAAVWSLGIL 231 + +K+ DFG L +Y D D R P +W+ + R + + VWS G+L Sbjct: 236 KNVVKICDFG----LARDIYKDPDYVRKGDARLPLKWMAPETIFDRVYTIQSDVWSFGVL 291 Query: 232 LYDMVC-GDIPF---EHDEEIIRG-QVFFRQR----VSSECQHLIRWCLALRPSDRPTFE 282 L+++ G P+ + DEE R + R R + E + C PS RPTF Sbjct: 292 LWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFS 351 Query: 283 EIQNH 287 E+ H Sbjct: 352 ELVEH 356 >2J0K-A nrPDB Length = 656 Score = 48.9 bits (115), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 68/273 (24%), Positives = 114/273 (41%), Gaps = 48/273 (17%) Query: 39 QVGPLLGSGGFGSVYSGIRVSDNLP---VAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 ++G +G G FG V+ GI +S P VAIK K+ SD Sbjct: 393 ELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTC-KNCTSD------------------S 433 Query: 96 VSSGFSGVIRLLDWFERPDSFVLI-LERPEPVQDLFDFITERGALQEELARSFF------ 148 V F + F+ P LI + PV + + T G L+ L F Sbjct: 434 VREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCT-LGELRSFLQVRKFSLDLAS 492 Query: 149 -----WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDG 203 +Q+ A+ + + +HRDI N+L+ +KL DFG ++D+ Y Sbjct: 493 LILYAYQLSTALAYLESKRFVHRDIAARNVLVSATDC-VKLGDFGLSRYMEDSTYYKASK 551 Query: 204 TRV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFE---HDEEIIRGQVFFR 256 ++ + PE I + R+ ++ VW G+ +++++ G PF+ +++ I R + R Sbjct: 552 GKLPIKWMAPESINFRRFTS-ASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGER 610 Query: 257 QRVSSEC----QHLIRWCLALRPSDRPTFEEIQ 285 + C L+ C A PS RP F E++ Sbjct: 611 LPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELK 643 >3OMV-A nrPDB Length = 307 Score = 48.5 bits (114), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 63/275 (22%), Positives = 112/275 (40%), Gaps = 45/275 (16%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 S+ + +GSG FG+VY G + ++ V I V + N EV +L+K Sbjct: 36 SEVMLSTRIGSGSFGTVYKG-KWHGDVAVKILKVVDPTPEQFQAFRN------EVAVLRK 88 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 I L + D+ ++ + E + Q Q + + Sbjct: 89 TRHV---NILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGM 145 Query: 156 RHCHNCGVLHRDIKDENILIDLNRG-ELKLIDFGSGALLKDTVYTDFDGTR--------- 205 + H ++HRD+K NI L+ G +K+ DFG TV + + G++ Sbjct: 146 DYLHAKNIIHRDMKSNNIF--LHEGLTVKIGDFGLA-----TVKSRWSGSQQVEQPTGSV 198 Query: 206 VYSPPEWIRYHRYHGRS--AAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR------- 256 ++ PE IR + S + V+S GI+LY+++ G++P+ H R Q+ F Sbjct: 199 LWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINN--RDQIIFMVGRGYAS 256 Query: 257 ---QRVSSEC----QHLIRWCLALRPSDRPTFEEI 284 ++ C + L+ C+ +RP F +I Sbjct: 257 PDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQI 291 >2Y6O-A nrPDB Length = 291 Score = 48.5 bits (114), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 58/251 (23%), Positives = 119/251 (47%), Gaps = 41/251 (16%) Query: 74 ISDWGELPNGT-RVPME---VVLLKKVSSGFSGVIR--------LLDWFERPDSFVL--I 119 + ++GE+ +G +VP + V +K + +G++ R ++ F+ P+ L + Sbjct: 24 VGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGV 83 Query: 120 LERPEPVQDLFDFITERGALQEELARS-----------FFWQVLEAVRHCHNCGVLHRDI 168 + + +PV + +++ E G+L L ++ + +++ + +HRD+ Sbjct: 84 VTKCKPVMIITEYM-ENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDL 142 Query: 169 KDENILIDLNRGELKLIDFGSGALLKD---TVYTDFDGT--RVYSPPEWIRYHRYHGRSA 223 NIL++ N K+ DFG +L+D YT G ++ PE I Y ++ ++ Sbjct: 143 AARNILVNSNL-VCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTS-AS 200 Query: 224 AVWSLGILLYD-MVCGDIPF--EHDEEIIRG-QVFFRQRVSSEC----QHLIRWCLALRP 275 VWS GI++++ M G+ P+ ++++I+ + +R +C L+ C Sbjct: 201 DVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKER 260 Query: 276 SDRPTFEEIQN 286 SDRP F +I N Sbjct: 261 SDRPKFGQIVN 271 >4OLI-A nrPDB Length = 645 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 40/165 (24%), Positives = 75/165 (45%), Gaps = 29/165 (17%) Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-----TVYTDF 201 F Q+ E + + H+ +HR++ N+L+D +R +K+ DFG + + V D Sbjct: 461 FAQQICEGMAYLHSQHYIHRNLAARNVLLDNDR-LVKIGDFGLAKAVPEGHEYYRVREDG 519 Query: 202 DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC--------------------GDIP 241 D + PE ++ ++++ ++ VWS G+ LY+++ G + Sbjct: 520 DSPVFWYAPECLKEYKFY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMT 578 Query: 242 FEHDEEII-RGQVFFR-QRVSSECQHLIRWCLALRPSDRPTFEEI 284 E++ RG+ R + E HL++ C S RPTFE + Sbjct: 579 VLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENL 623 >4YFF-A nrPDB Length = 311 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 56/219 (25%), Positives = 99/219 (45%), Gaps = 22/219 (10%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 S+ + ++GSG FG VY G R + + VAIK + ++ R EV +L + Sbjct: 42 SEIEFHEIIGSGSFGKVYKG-RCRNKI-VAIKRYRANTYCSKSDVDMFCR---EVSILCQ 96 Query: 96 VSSGFSGVIRLLD-WFERPDSFVLILERPEPVQDLFDFITERGA---LQEELARSFFWQV 151 ++ VI+ + P F ++ + LF + E+ LQ +L + V Sbjct: 97 LNH--PCVIQFVGACLNDPSQFAIVTQYISG-GSLFSLLHEQKRILDLQSKLIIAV--DV 151 Query: 152 LEAVRHCHNCG--VLHRDIKDENILIDLNRGELKLIDFGSGALLK----DTVYTDFDGTR 205 + + + HN ++HRD+ NIL+ G + DFG L+ D + R Sbjct: 152 AKGMEYLHNLTQPIIHRDLNSHNILL-YEDGHAVVADFGESRFLQSLDEDNMTKQPGNLR 210 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH 244 +P + + RY + A V+S + L++++ G+IPF H Sbjct: 211 WMAPEVFTQCTRYTIK-ADVFSYALCLWEILTGEIPFAH 248 >4IX6-A nrPDB Length = 350 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 51/181 (28%), Positives = 77/181 (42%), Gaps = 23/181 (12%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV- 90 EP + + GPL GSG FG+V+ G+ D V +K+ + D ++ L V V Sbjct: 17 EPKDIRVLPGPL-GSGNFGTVFRGVFKGDQ-DVVLKNAKADVMAAEELLECEMDVNYHVH 74 Query: 91 VLLKKVSSGFSGVIRL------------------LDWFERPDSFVLILERPEPVQDLFDF 132 K + F G I L L W ++ V L R L Sbjct: 75 ANAKGTCARFMGCIELGAKDGGEIYNGTLTEGLWLMWANEGENTVEALMR-RGTAPLATA 133 Query: 133 ITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDEN-ILIDLNRGELKLIDFGSGA 191 + A + + + ++L ++ H CGV+HRD+K N I + + G LKLID G+ A Sbjct: 134 MACADATELGVTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAA 193 Query: 192 L 192 L Sbjct: 194 L 194 >6J5U-C nrPDB Length = 426 Score = 48.5 bits (114), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 58/219 (26%), Positives = 94/219 (42%), Gaps = 40/219 (18%) Query: 43 LLGSGGFGSVYSG---------IRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 LLG GGFG V+ G R + VA+K ++ + E EV L Sbjct: 91 LLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKEWLT------EVNYL 144 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 ++S ++ L+ + ++ +L+ E P L + + RGA + W + Sbjct: 145 GQLS--HPNLVLLVGYCAEGENRLLVYEF-MPKGSLENHLFRRGA------QPLTWAIRM 195 Query: 154 AVR----------HCHNCGVLHRDIKDENILIDLNRGELKLIDFG---SGALLKDT-VYT 199 V H V++RD K NIL+D + KL DFG +G +T V T Sbjct: 196 KVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADF-NAKLSDFGLAKAGPTGDNTHVST 254 Query: 200 DFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCG 238 GT Y+ PE++ R +S V+S G++L +++ G Sbjct: 255 KVIGTHGYAAPEYVATGRLTAKS-DVYSFGVVLLELISG 292 >3C1X-A nrPDB Length = 373 Score = 48.1 bits (113), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 56/229 (24%), Positives = 104/229 (45%), Gaps = 27/229 (11%) Query: 43 LLGSGGFGSVYSGIRVSDN---LPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 99 ++G G FG VY G + ++ + A+K + +RI+D GE+ ++ E +++K S Sbjct: 96 VIGRGHFGCVYHGTLLDNDGKKIHCAVKSL--NRITDIGEV---SQFLTEGIIMKDFSH- 149 Query: 100 FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI---TERGALQEELARSFFWQVLEAVR 156 V+ LL R + L++ DL +FI T +++ + F QV + ++ Sbjct: 150 -PNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIG--FGLQVAKGMK 206 Query: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDG----TRVYSPPEW 212 + +HRD+ N ++D + +K+ DFG L +D +FD T P +W Sbjct: 207 FLASKKFVHRDLAARNCMLD-EKFTVKVADFG---LARDMYDKEFDSVHNKTGAKLPVKW 262 Query: 213 IRYHRYHGRS----AAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ 257 + + + VWS G+LL++++ P D V+ Q Sbjct: 263 MALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQ 311 >5TOS-A nrPDB Length = 395 Score = 48.1 bits (113), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 71/290 (24%), Positives = 128/290 (44%), Gaps = 64/290 (22%) Query: 43 LLGSGGFGSVYSG---------IRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 ++G GGFG V+ G + L +A+K + ++ E E+ L Sbjct: 72 VIGEGGFGCVFKGWLDESTLTPTKPGTGLVIAVKKLNQEGFQGHREWLT------EINYL 125 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQV-- 151 ++S +++L+ + + +L+ E + L + + RGA + L +F +V Sbjct: 126 GQLSH--PNLVKLIGYCLEDEHRLLVYEFMQK-GSLENHLFRRGAYFKPLP--WFLRVNV 180 Query: 152 -LEAVR-----HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-------VY 198 L+A + H V++RDIK NIL+D + KL DFG L +D V Sbjct: 181 ALDAAKGLAFLHSDPVKVIYRDIKASNILLDADYNA-KLSDFG---LARDGPMGDLSYVS 236 Query: 199 TDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-----EEII---R 250 T GT Y+ PE++ + RS V+S G+LL +++ G +H+ E ++ R Sbjct: 237 TRVMGTYGYAAPEYMSSGHLNARS-DVYSFGVLLLEILSGKRALDHNRPAKEENLVDWAR 295 Query: 251 GQVFFRQRV------SSECQHL----IRW------CLALRPSDRPTFEEI 284 + +++V + Q+L +R CL+ P RPT +++ Sbjct: 296 PYLTSKRKVLLIVDNRLDTQYLPEEAVRMASVAVQCLSFEPKSRPTMDQV 345 >4HVI-A nrPDB Length = 314 Score = 47.8 bits (112), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 68/274 (24%), Positives = 111/274 (40%), Gaps = 43/274 (15%) Query: 44 LGSGGFGSV----YSGIRVSDNLPVAIKHVEKDRISDWGELPNGTR-VPMEVVLLKKVSS 98 LG G FGSV Y + + VA+K ++ P+ R E+ +LK + S Sbjct: 18 LGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSG-------PDQQRDFQREIQILKALHS 70 Query: 99 GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSFFWQVLEAVRH 157 F R + + S L++E P L DF+ R L + Q+ + + + Sbjct: 71 DFIVKYRGVSYGPGRQSLRLVMEY-LPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEY 129 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL---KDTVYTDFDGTR--VYSPPEW 212 + +HRD+ NIL++ + +K+ DFG LL KD G + PE Sbjct: 130 LGSRRCVHRDLAARNILVE-SEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPES 188 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEEIIRGQVFFR--------------- 256 + + + R + VWS G++LY++ D E +R R Sbjct: 189 LSDNIF-SRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGSERDVPALSRLLELLEEG 247 Query: 257 QRV------SSECQHLIRWCLALRPSDRPTFEEI 284 QR+ +E L++ C A P DRP+F + Sbjct: 248 QRLPAPPACPAEVHELMKLCWAPSPQDRPSFSAL 281 >5WNL-A nrPDB Length = 342 Score = 47.8 bits (112), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 64/268 (23%), Positives = 101/268 (37%), Gaps = 39/268 (14%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIK-----HVEKDRISDWGELPNGTRVPMEVVLLKKVSS 98 +GSGGFG VY V +AIK HV+ + E + +L Sbjct: 28 VGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVYGI 87 Query: 99 GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHC 158 V ++++ E L+ P P F + E + +F HC Sbjct: 88 CQEPVGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETA-----VGMNFL--------HC 134 Query: 159 HNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL-----LKDTVYTDFDGTRVYSPPEWI 213 + +LH ++K NIL+D + +K+ DFG D GT Y PPE I Sbjct: 135 MSPPLLHLNLKPANILLDAHY-HVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERI 193 Query: 214 R-YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF--------------RQR 258 R R V+S I+++ ++ PF ++ I+ + R R Sbjct: 194 REKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKGHRPELPPICRPRPR 253 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQN 286 + L++ C P RPTF+EI + Sbjct: 254 ACASLIGLMQRCWHADPQVRPTFQEITS 281 >4K33-A nrPDB Length = 325 Score = 47.4 bits (111), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 39/155 (25%), Positives = 72/155 (46%), Gaps = 22/155 (14%) Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDF--DG 203 S +QV + + + +HRD+ N+L+ + +K+ DFG L +D D+ + Sbjct: 162 SCAYQVARGMEYLASQKCIHRDLAARNVLVTED-NVMKIADFG---LARDVHNLDYYKET 217 Query: 204 TRVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVC------GDIPFEHDEEIIRGQV 253 T P +W+ + R + + VWS G+LL+++ IP E ++++ Sbjct: 218 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEG- 276 Query: 254 FFRQRVSSECQH----LIRWCLALRPSDRPTFEEI 284 R + C H ++R C PS RPTF+++ Sbjct: 277 -HRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQL 310 >4JLC-A nrPDB Length = 657 Score = 47.4 bits (111), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 29/103 (28%), Positives = 48/103 (46%), Gaps = 11/103 (10%) Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLN---RGELKLIDFGSGALLKD-TVYTDFDGTRV 206 V+ + H G++HRDIK NI+ + + KL DFG+ L+D + GT Sbjct: 120 VVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 179 Query: 207 YSPPEWIR-------YHRYHGRSAAVWSLGILLYDMVCGDIPF 242 Y P+ + + +G + +WS+G+ Y G +PF Sbjct: 180 YLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPF 222 >1K9A-A nrPDB Length = 450 Score = 47.0 bits (110), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 58/256 (22%), Positives = 108/256 (42%), Gaps = 29/256 (11%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 +G G FG V G + VA+K ++ D + E ++ ++ S + Sbjct: 201 IGKGEFGDVMLGDYRGNK--VAVKCIKNDATAQ--------AFLAEASVMTQLRH--SNL 248 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLEAVRHCHNC 161 ++LL + I+ L D++ RG L + F V EA+ + Sbjct: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308 Query: 162 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTR--VYSPPEWIRYHRYH 219 +HRD+ N+L+ + K+ DFG L K+ T G ++ PE +R ++ Sbjct: 309 NFVHRDLAARNVLVSEDN-VAKVSDFG---LTKEASSTQDTGKLPVKWTAPEALREKKFS 364 Query: 220 GRSAAVWSLGILLYDMVC-GDIPFEH---DEEIIRGQVFFRQRVSSEC----QHLIRWCL 271 +S VWS GILL+++ G +P+ + + R + ++ C +++ C Sbjct: 365 TKS-DVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCW 423 Query: 272 ALRPSDRPTFEEIQNH 287 L + RPTF +++ Sbjct: 424 HLDAATRPTFLQLREQ 439 >5EG3-A nrPDB Length = 334 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 38/153 (24%), Positives = 73/153 (47%), Gaps = 18/153 (11%) Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDF--DG 203 S +Q+ + + + +HRD+ N+L+ N +K+ DFG L +D DF + Sbjct: 161 SCTYQLARGMEYLASQKCIHRDLAARNVLVTEN-NVMKIADFG---LARDINNIDFFKET 216 Query: 204 TRVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVC------GDIPFEHDEEIIR-GQ 252 T P +W+ + R + + VWS G+L++++ IP E ++++ G Sbjct: 217 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH 276 Query: 253 VFFR-QRVSSECQHLIRWCLALRPSDRPTFEEI 284 + ++E ++R C PS RPTF+++ Sbjct: 277 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQL 309 >1U59-A nrPDB Length = 287 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 59/264 (22%), Positives = 113/264 (42%), Gaps = 37/264 (14%) Query: 44 LGSGGFGSVYSGI--RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS 101 LG G FGSV G+ + VAIK +++ E + + E ++ ++ + + Sbjct: 18 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT-----EKADTEEMMREAQIMHQLDNPY- 71 Query: 102 GVIRLLDWFERPDSFVLILERP--EPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 159 ++RL+ + ++ +L++E P+ + +R + QV +++ Sbjct: 72 -IVRLIG-VCQAEALMLVMEMAGGGPLHKF--LVGKREEIPVSNVAELLHQVSMGMKYLE 127 Query: 160 NCGVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYTDFDGTR---VYSPPEWIR 214 +HRD+ N+L+ +NR K+ DFG L D+ YT + + PE I Sbjct: 128 EKNFVHRDLAARNVLL-VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN 186 Query: 215 YHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEEIIRG---QVFFRQRVSSEC------- 263 + ++ RS VWS G+ +++ + G P++ ++G F Q EC Sbjct: 187 FRKFSSRS-DVWSYGVTMWEALSYGQKPYKK----MKGPEVMAFIEQGKRMECPPECPPE 241 Query: 264 -QHLIRWCLALRPSDRPTFEEIQN 286 L+ C + DRP F ++ Sbjct: 242 LYALMSDCWIYKWEDRPDFLTVEQ 265 >6CQF-A nrPDB Length = 297 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 66/265 (24%), Positives = 114/265 (43%), Gaps = 37/265 (13%) Query: 44 LGSGGFGSVYSGI-RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 LG G +G V+ +VS +L VA+K V+ + D L E+++LK + + Sbjct: 24 LGGGTYGEVFKARDKVSGDL-VALKMVKMEPDDDVSTLQK------EILILK--TCRHAN 74 Query: 103 VIRLLDWFERPDSFVLILE--RPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHN 160 ++ + + +E +QD++ G+L E +VL+ + + H+ Sbjct: 75 IVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVT---GSLSELQISYVCREVLQGLAYLHS 131 Query: 161 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY--TDFDGTRVYSPPEWIRYHRY 218 +HRDIK NILI+ + GE++L DFG A + T+ F GT + PE Sbjct: 132 QKKIHRDIKGANILIN-DAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEVAAVALK 190 Query: 219 HGRS--AAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF--------------RQRVSSE 262 G + +WSLGI ++ P D +R V F + + S+ Sbjct: 191 GGYNELCDIWSLGITAIELAELQPPL-FDVHPLR--VLFLMTKSGYQPPRLKEKGKWSAA 247 Query: 263 CQHLIRWCLALRPSDRPTFEEIQNH 287 + I+ L P RP+ ++ +H Sbjct: 248 FHNFIKVTLTKSPKKRPSATKMLSH 272 >4G3E-A nrPDB Length = 352 Score = 47.0 bits (110), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 53/212 (25%), Positives = 84/212 (39%), Gaps = 30/212 (14%) Query: 42 PLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG-- 99 P +G G FG V+ A+K V + RV E+V +SS Sbjct: 80 PRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVF----------RVE-ELVACAGLSSPRI 128 Query: 100 --FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 G +R W + F+ +LE L I + G L E+ A + Q LE + + Sbjct: 129 VPLYGAVREGPWV---NIFMELLEG----GSLGQLIKQMGCLPEDRALYYLGQALEGLEY 181 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL------KDTVYTDF-DGTRVYSPP 210 H +LH D+K +N+L+ + L DFG L K + D+ GT + P Sbjct: 182 LHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAP 241 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF 242 E + + +WS ++ M+ G P+ Sbjct: 242 EVVMGKPCDAK-VDIWSSCCMMLHMLNGCHPW 272 >6O8B-A nrPDB Length = 665 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 28/103 (27%), Positives = 49/103 (47%), Gaps = 11/103 (10%) Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLN---RGELKLIDFGSGALLKD-TVYTDFDGTRV 206 V+ + H G++HR+IK NI+ + + KL DFG+ L+D + + GT Sbjct: 127 VVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEE 186 Query: 207 YSPPEWIR-------YHRYHGRSAAVWSLGILLYDMVCGDIPF 242 Y P+ + + +G + +WS+G+ Y G +PF Sbjct: 187 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 229 >4EUT-A nrPDB Length = 396 Score = 46.6 bits (109), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 11/103 (10%) Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLN---RGELKLIDFGSGALLKD-TVYTDFDGTRV 206 V+ + H G++HR+IK NI+ + + KL DFG+ L+D + GT Sbjct: 121 VVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 180 Query: 207 YSPPEWIR-------YHRYHGRSAAVWSLGILLYDMVCGDIPF 242 Y P+ + + +G + +WS+G+ Y G +PF Sbjct: 181 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 223 >1JPA-A nrPDB Length = 312 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 65/287 (22%), Positives = 124/287 (43%), Gaps = 63/287 (21%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 S ++ ++G+G FG V SG H++ LP + V +K Sbjct: 33 SCVKIEQVIGAGEFGEVCSG------------HLK---------LPGKREI---FVAIKT 68 Query: 96 VSSGFSGVIR--------LLDWFERPDSFVL--ILERPEPVQDLFDFITERGALQEELAR 145 + SG++ R ++ F+ P+ L ++ + PV + +F+ E G+L L + Sbjct: 69 LKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFM-ENGSLDSFLRQ 127 Query: 146 S-----------FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK 194 + + +++ + +HRD+ NIL++ N K+ DFG L+ Sbjct: 128 NDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNL-VCKVSDFGLSRFLE 186 Query: 195 DT----VYTDFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYD-MVCGDIPF--EH 244 D YT G ++ ++ PE I+Y ++ S VWS GI++++ M G+ P+ Sbjct: 187 DDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSAS-DVWSYGIVMWEVMSYGERPYWDMT 245 Query: 245 DEEIIRG-QVFFRQRVSSEC----QHLIRWCLALRPSDRPTFEEIQN 286 ++++I + +R +C L+ C + RP F +I N Sbjct: 246 NQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVN 292 >5WNO-A nrPDB Length = 330 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 59/271 (21%), Positives = 116/271 (42%), Gaps = 40/271 (14%) Query: 35 ESQYQVGPLLGSGGFGSVYSGI----RVSD-NLPVAIKHVEKDRISDWGELPNGTRVPME 89 E Q ++ LG+G FG+V++GI R + +PVAIK + D+ L T + Sbjct: 21 ELQTKLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVAIKVFQTDQSQTDEMLEEATNM--- 77 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSF-VLILERP-EPVQDLFDFITERGALQEELARSF 147 +++++ + D ++ + RP +Q+ E +E++ + Sbjct: 78 ------FRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVL--Y 129 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVY 207 +Q+ +++ V+HRD+ N+L+ +++ DFG +LK D D + Sbjct: 130 CYQIASGMQYLEKQRVVHRDLATRNVLVK-KFNHVEITDFGLSKILKH----DADSITIK 184 Query: 208 SPPEWIRY-------HRYHGRSAAVWSLGILLYDMVC-GDIPFE-HDEEIIRGQVFFRQR 258 S I++ + ++ VW+ G+ ++++ G P++ + I + R Sbjct: 185 SGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNR 244 Query: 259 VSS--EC-----QHLIRWCLALRPSDRPTFE 282 +S C Q L+R C P RP FE Sbjct: 245 LSQPPNCSQDLYQELLR-CWMADPKSRPGFE 274 >4EUU-A nrPDB Length = 319 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 11/103 (10%) Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLN---RGELKLIDFGSGALLKD-TVYTDFDGTRV 206 V+ + H G++HR+IK NI+ + + KL DFG+ L+D + GT Sbjct: 121 VVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 180 Query: 207 YSPPEWIR-------YHRYHGRSAAVWSLGILLYDMVCGDIPF 242 Y P+ + + +G + +WS+G+ Y G +PF Sbjct: 181 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 223 >4CRS-A nrPDB Length = 341 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 37/128 (28%), Positives = 61/128 (47%), Gaps = 16/128 (12%) Query: 178 NRGELKLIDFG---SGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYD 234 G +K+ DFG G D T F GT + PE + Y R+ W LG+L+Y+ Sbjct: 149 TEGFVKIADFGLCKEGMGYGDRTST-FCGTPEFLAPEVLTETSY-TRAVDWWGLGVLIYE 206 Query: 235 MVCGDIPFEHDEE------IIRGQVFFRQRVSSECQHLIRWCLALRPSDR-----PTFEE 283 M+ G+ PF D+E I+ +V + + +S+E ++R L P R E+ Sbjct: 207 MLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIMRRLLRRNPERRLGASEKDAED 266 Query: 284 IQNHPWMQ 291 ++ HP+ + Sbjct: 267 VKKHPFFR 274 >6NT9-A nrPDB Length = 742 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 11/103 (10%) Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLN---RGELKLIDFGSGALLKD-TVYTDFDGTRV 206 V+ + H G++HR+IK NI+ + + KL DFG+ L+D + GT Sbjct: 119 VVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEE 178 Query: 207 YSPPEWIR-------YHRYHGRSAAVWSLGILLYDMVCGDIPF 242 Y P+ + + +G + +WS+G+ Y G +PF Sbjct: 179 YLHPDMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPF 221 >3MIA-A nrPDB Length = 351 Score = 45.8 bits (107), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 31/91 (34%), Positives = 49/91 (53%), Gaps = 7/91 (7%) Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG---SGALLKDTV---YTDFDGT 204 +L + + H +LHRD+K N+LI + G LKL DFG + +L K++ YT+ T Sbjct: 133 LLNGLYYIHRNKILHRDMKAANVLITRD-GVLKLADFGLARAFSLAKNSQPNRYTNRVVT 191 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDM 235 Y PPE + R +G +W G ++ +M Sbjct: 192 LWYRPPELLLGERDYGPPIDLWGAGCIMAEM 222 >1BYG-A nrPDB Length = 278 Score = 45.8 bits (107), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 62/273 (22%), Positives = 114/273 (41%), Gaps = 35/273 (12%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 +G G FG V G + VA+K ++ D E ++ ++ S + Sbjct: 29 IGKGEFGDVMLGDYRGNK--VAVKCIKND--------ATAQAFLAEASVMTQLRH--SNL 76 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLEAVRHCHNC 161 ++LL + I+ L D++ RG L + F V EA+ + Sbjct: 77 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 136 Query: 162 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTR--VYSPPEWIRYHRYH 219 +HRD+ N+L+ + K+ DFG L K+ T G ++ PE +R ++ Sbjct: 137 NFVHRDLAARNVLVSEDN-VAKVSDFG---LTKEASSTQDTGKLPVKWTAPEALREKKFS 192 Query: 220 GRSAAVWSLGILLYDMVC-GDIPFEH---DEEIIRGQVFFRQRVSSEC----QHLIRWCL 271 +S VWS GILL+++ G +P+ + + R + ++ C +++ C Sbjct: 193 TKS-DVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCW 251 Query: 272 ALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHL 304 L + RP+F +++ L +T E+HL Sbjct: 252 HLDAAMRPSFLQLREQ------LEHIKTHELHL 278 >2Y4I-B nrPDB Length = 319 Score = 45.8 bits (107), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 61/278 (21%), Positives = 120/278 (43%), Gaps = 37/278 (13%) Query: 33 PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVL 92 P E Q ++G L+G G FG VY G R + + + +E+D + +L R EV+ Sbjct: 31 PFE-QLEIGELIGKGRFGQVYHG-RWHGEVAIRLIDIERD---NEDQLKAFKR---EVMA 82 Query: 93 LKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSFFWQV 151 ++ V+ + P +I + + L+ + + + L R ++ Sbjct: 83 YRQTRH--ENVVLFMGACMSPPHLAIITSLCKG-RTLYSVVRDAKIVLDVNKTRQIAQEI 139 Query: 152 LEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG----SGALL---KDTVYTDFDGT 204 ++ + + H G+LH+D+K +N+ D G++ + DFG SG L ++ +G Sbjct: 140 VKGMGYLHAKGILHKDLKSKNVFYD--NGKVVITDFGLFSISGVLQAGRREDKLRIQNGW 197 Query: 205 RVYSPPEWIRY--------HRYHGRSAAVWSLGILLYDMVCGDIPFE-HDEEIIRGQVFF 255 + PE IR + + V++LG + Y++ + PF+ E I Q+ Sbjct: 198 LCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGT 257 Query: 256 RQR-------VSSECQHLIRWCLALRPSDRPTFEEIQN 286 + + E ++ +C A +RPTF ++ + Sbjct: 258 GMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMD 295 >4XCU-A nrPDB Length = 300 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 70/273 (25%), Positives = 115/273 (42%), Gaps = 39/273 (14%) Query: 40 VGPLLGSGGFGSVYSG-------IRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVL 92 +G LG G FG V R VA+K + KD SD +L + MEV+ Sbjct: 21 LGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKML-KDNASD-KDLADLVS-EMEVM- 76 Query: 93 LKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER-------GALQEELAR 145 K+ +I LL + +I+E +L +F+ R G L + Sbjct: 77 --KLIGRHKNIINLLGVCTQEGPLYVIVECAAK-GNLREFLRARRPPGSSEGPLSFPVLV 133 Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDF--DG 203 S +QV +++ + +HRD+ N+L+ + +K+ DFG L + + D+ Sbjct: 134 SCAYQVARGMQYLESRKCIHRDLAARNVLVTED-NVMKIADFG---LARGVHHIDYYKKT 189 Query: 204 TRVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVC------GDIPFEHDEEIIR-GQ 252 + P +W+ + R + + VWS GILL+++ IP E ++R G Sbjct: 190 SNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGH 249 Query: 253 VFFRQ-RVSSECQHLIRWCLALRPSDRPTFEEI 284 R E L+R C PS RPTF+++ Sbjct: 250 RMDRPPHCPPELYGLMRECWHAAPSQRPTFKQL 282 >2H34-A nrPDB Length = 309 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 58/218 (26%), Positives = 93/218 (42%), Gaps = 13/218 (5%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 Y++ L+G GG G VY VA+K + + SD TR+ E ++ Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDP---VFRTRMQREARTAGRLQ 92 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 V+ + D+ E + + V DL + +G L A + Q+ A+ Sbjct: 93 EPH--VVPIHDFGEIDGQLYVDMRLINGV-DLAAMLRRQGPLAPPRAVAIVRQIGSALDA 149 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD---GTRVYSPPEWIR 214 H G HRD+K ENIL+ + L+DFG + D T GT Y PE R Sbjct: 150 AHAAGATHRDVKPENILVSADDFAY-LVDFGIASATTDEKLTQLGNTVGTLYYMAPE--R 206 Query: 215 YHRYHGR-SAAVWSLGILLYDMVCGDIPFEHDEEIIRG 251 + H A +++L +LY+ + G P++ D+ + G Sbjct: 207 FSESHATYRADIYALTCVLYECLTGSPPYQGDQLSVMG 244 >3TT0-A nrPDB Length = 382 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 37/153 (24%), Positives = 73/153 (47%), Gaps = 18/153 (11%) Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDF--DG 203 S +QV + + + +HRD+ N+L+ + +K+ DFG L +D + D+ Sbjct: 195 SCAYQVARGMEYLASKKCIHRDLAARNVLVTEDN-VMKIADFG---LARDIHHIDYYKKT 250 Query: 204 TRVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVC------GDIPFEHDEEIIR-GQ 252 T P +W+ + R + + VWS G+LL+++ +P E ++++ G Sbjct: 251 TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH 310 Query: 253 VFFR-QRVSSECQHLIRWCLALRPSDRPTFEEI 284 + ++E ++R C PS RPTF+++ Sbjct: 311 RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQL 343 >5A46-A nrPDB Length = 386 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 37/153 (24%), Positives = 73/153 (47%), Gaps = 18/153 (11%) Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDF--DG 203 S +QV + + + +HRD+ N+L+ + +K+ DFG L +D + D+ Sbjct: 166 SCAYQVARGMEYLASKKCIHRDLAARNVLVTED-NVMKIADFG---LARDIHHIDYYKKT 221 Query: 204 TRVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVC------GDIPFEHDEEIIR-GQ 252 T P +W+ + R + + VWS G+LL+++ +P E ++++ G Sbjct: 222 TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH 281 Query: 253 VFFR-QRVSSECQHLIRWCLALRPSDRPTFEEI 284 + ++E ++R C PS RPTF+++ Sbjct: 282 RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQL 314 >3LLT-A nrPDB Length = 360 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 59/245 (24%), Positives = 97/245 (39%), Gaps = 42/245 (17%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTR-VPMEVVL 92 L + + V +G G FG V + + A+K V + TR +E + Sbjct: 33 LNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVR--------NIKKYTRSAKIEADI 84 Query: 93 LKKVSSGFSGVIRLLDW---FERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSF 147 LKK+ + ++ + F D LI E P L++ IT E + + Sbjct: 85 LKKIQNDDINNNNIVKYHGKFMYYDHMCLIFEPLGP--SLYEIITRNNYNGFHIEDIKLY 142 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILID-------------LNRGE-----------LK 183 ++L+A+ + + H D+K ENIL+D + G+ +K Sbjct: 143 CIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTKSTGIK 202 Query: 184 LIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE 243 LIDFG A K + TR Y PE I + S+ +WS G +L ++ G + F Sbjct: 203 LIDFGC-ATFKSDYHGSIINTRQYRAPEVILNLGW-DVSSDMWSFGCVLAELYTGSLLFR 260 Query: 244 HDEEI 248 E + Sbjct: 261 THEHM 265 >2OZO-A nrPDB Length = 613 Score = 45.4 bits (106), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 58/264 (21%), Positives = 113/264 (42%), Gaps = 37/264 (14%) Query: 44 LGSGGFGSVYSGI--RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS 101 LG G FGSV G+ + VAIK +++ E + + E ++ ++ + + Sbjct: 344 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT-----EKADTEEMMREAQIMHQLDNPY- 397 Query: 102 GVIRLLDWFERPDSFVLILERP--EPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 159 ++RL+ + ++ +L++E P+ + +R + QV +++ Sbjct: 398 -IVRLIGVCQ-AEALMLVMEMAGGGPLHKF--LVGKREEIPVSNVAELLHQVSMGMKYLE 453 Query: 160 NCGVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYTDFDGTR---VYSPPEWIR 214 +HR++ N+L+ +NR K+ DFG L D+ YT + + PE I Sbjct: 454 EKNFVHRNLAARNVLL-VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECIN 512 Query: 215 YHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEEIIRG---QVFFRQRVSSEC------- 263 + ++ RS VWS G+ +++ + G P++ ++G F Q EC Sbjct: 513 FRKFSSRS-DVWSYGVTMWEALSYGQKPYKK----MKGPEVMAFIEQGKRMECPPECPPE 567 Query: 264 -QHLIRWCLALRPSDRPTFEEIQN 286 L+ C + DRP F ++ Sbjct: 568 LYALMSDCWIYKWEDRPDFLTVEQ 591 >3PLS-A nrPDB Length = 298 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 61/258 (23%), Positives = 113/258 (43%), Gaps = 29/258 (11%) Query: 43 LLGSGGFGSVYSGIRV---SDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 99 ++G G FG VY G + + + AIK + RI++ ++ R E +L++ ++ Sbjct: 28 VIGKGHFGVVYHGEYIDQAQNRIQCAIKSL--SRITEMQQVEAFLR---EGLLMRGLNH- 81 Query: 100 FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT--ERGALQEELARSFFWQVLEAVRH 157 V+ L+ P+ +L DL FI +R ++L SF QV + + Sbjct: 82 -PNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLI-SFGLQVARGMEY 139 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTR-VYSPPEW---- 212 +HRD+ N ++D +K+ DFG + D Y R P +W Sbjct: 140 LAEQKFVHRDLAARNCMLD-ESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWTALE 198 Query: 213 -IRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEEIIRGQVFFRQRVSSECQH----- 265 ++ +R+ +S VWS G+LL++++ G P+ H + + R + ++ Sbjct: 199 SLQTYRFTTKSD-VWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSL 257 Query: 266 --LIRWCLALRPSDRPTF 281 +++ C P+ RPTF Sbjct: 258 YQVMQQCWEADPAVRPTF 275 >3GQL-A nrPDB Length = 326 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 37/153 (24%), Positives = 73/153 (47%), Gaps = 18/153 (11%) Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDF--DG 203 S +QV + + + +HRD+ N+L+ + +K+ DFG L +D + D+ Sbjct: 154 SCAYQVARGMEYLASKKCIHRDLAARNVLVTED-NVMKIADFG---LARDIHHIDYYKKT 209 Query: 204 TRVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVC------GDIPFEHDEEIIR-GQ 252 T P +W+ + R + + VWS G+LL+++ +P E ++++ G Sbjct: 210 TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH 269 Query: 253 VFFR-QRVSSECQHLIRWCLALRPSDRPTFEEI 284 + ++E ++R C PS RPTF+++ Sbjct: 270 RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQL 302 >2PSQ-A nrPDB Length = 370 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 37/153 (24%), Positives = 72/153 (47%), Gaps = 18/153 (11%) Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDF--DG 203 S +Q+ + + + +HRD+ N+L+ N +K+ DFG L +D D+ Sbjct: 207 SCTYQLARGMEYLASQKCIHRDLAARNVLVTEN-NVMKIADFG---LARDINNIDYYKKT 262 Query: 204 TRVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVC------GDIPFEHDEEIIR-GQ 252 T P +W+ + R + + VWS G+L++++ IP E ++++ G Sbjct: 263 TNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGH 322 Query: 253 VFFR-QRVSSECQHLIRWCLALRPSDRPTFEEI 284 + ++E ++R C PS RPTF+++ Sbjct: 323 RMDKPANCTNELYMMMRDCWHAVPSQRPTFKQL 355 >5VD3-A nrPDB Length = 311 Score = 45.1 bits (105), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 69/294 (23%), Positives = 115/294 (39%), Gaps = 29/294 (9%) Query: 12 LRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHV-- 69 R L + P + + + +Q LG G +G V+ D A+K Sbjct: 33 FRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMS 92 Query: 70 ----EKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEP 125 KDR E+ + +V +RL +E L E P Sbjct: 93 PFRGPKDRARKLAEVGSHEKVGQHPC-----------CVRLEQAWEEGGILYLQTELCGP 141 Query: 126 VQDLFDFITERGA-LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKL 184 L GA L E + L A+ H H+ G++H D+K NI + RG KL Sbjct: 142 --SLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLG-PRGRCKL 198 Query: 185 IDFGSGALLKDTVYTDF-DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCG-DIPF 242 DFG L + +G Y PE ++ +G +A V+SLG+ + ++ C ++P Sbjct: 199 GDFGLLVELGTAGAGEVQEGDPRYMAPELLQGS--YGTAADVFSLGLTILEVACNMELPH 256 Query: 243 EHD--EEIIRGQV--FFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 + +++ +G + F +SSE + ++ L P R T E + P ++ Sbjct: 257 GGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQ 310 >4NEU-A nrPDB Length = 333 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 46/214 (21%), Positives = 82/214 (38%), Gaps = 33/214 (15%) Query: 101 SGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHN 160 S V++LL + L++E E +L + + + +++E + + H Sbjct: 82 SRVVKLLGVIIEEGKYSLVMEYMEK-GNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHG 140 Query: 161 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLK---------------DTVYTDFDGTR 205 GV+H+D+K ENIL+D N +K+ D G + D GT Sbjct: 141 KGVIHKDLKPENILVD-NDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTL 199 Query: 206 VYSPPEWIR-YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF--------- 255 Y PE + + + V+S ++L+ + P+E+ I Q+ Sbjct: 200 YYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYEN--AICEQQLIMCIKSGNRPD 257 Query: 256 ----RQRVSSECQHLIRWCLALRPSDRPTFEEIQ 285 + E L++ C P RPTF I+ Sbjct: 258 VDDITEYCPREIISLMKLCWEANPEARPTFPGIE 291 >4M69-B nrPDB Length = 283 Score = 44.7 bits (104), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 50/215 (23%), Positives = 93/215 (43%), Gaps = 23/215 (10%) Query: 89 EVVLLKKVSSGFSGVIRL----LDWFERPDSFVLILERPEPVQDLFDFITERGALQEELA 144 E+ +KK S ++R+ +D +P F +++E E + L + + L + Sbjct: 58 EIKTMKKFDS--PNILRIFGICIDQTVKPPEFSIVMEYCE-LGTLRELLDREKDLTMSVR 114 Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDF------GSGALLKDTVY 198 + + H+ LHR+I + L+ ++KL F S + + Sbjct: 115 SLLVLRAARGLYRLHHSETLHRNISSSSFLV-AGGYQVKLAGFELSKTQNSISRTAKSTK 173 Query: 199 TDFDGTRVYSPPEWIRY-HRYHGRSAAVWSLGILLYDMVCGDIPFEH-DEEIIRGQVFFR 256 + + +Y PE ++ + A ++S GI+L+++ G IPFE D + IR V Sbjct: 174 AERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAED 233 Query: 257 QR---VSSECQHLIR----WCLALRPSDRPTFEEI 284 ++ V +C L+R C A PS RP+ + I Sbjct: 234 KKQEPVGQDCPELLREIINECRAHEPSQRPSVDGI 268 >4BTF-A nrPDB Length = 469 Score = 44.3 bits (103), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 50/215 (23%), Positives = 93/215 (43%), Gaps = 23/215 (10%) Query: 89 EVVLLKKVSSGFSGVIRL----LDWFERPDSFVLILERPEPVQDLFDFITERGALQEELA 144 E+ +KK S ++R+ +D +P F +++E E + L + + L + Sbjct: 244 EIKTMKKFDS--PNILRIFGICIDQTVKPPEFSIVMEYCE-LGTLRELLDREKDLTMSVR 300 Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDF------GSGALLKDTVY 198 + + H+ LHR+I + L+ ++KL F S + + Sbjct: 301 SLLVLRAARGLYRLHHSETLHRNISSSSFLV-AGGYQVKLAGFELSKTQNSISRTAKSTK 359 Query: 199 TDFDGTRVYSPPEWIRY-HRYHGRSAAVWSLGILLYDMVCGDIPFEH-DEEIIRGQVFFR 256 + + +Y PE ++ + A ++S GI+L+++ G IPFE D + IR V Sbjct: 360 AERSSSTIYVSPERLKNPFCLYDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAED 419 Query: 257 QR---VSSECQHLIR----WCLALRPSDRPTFEEI 284 ++ V +C L+R C A PS RP+ + I Sbjct: 420 KKQEPVGQDCPELLREIINECRAHEPSQRPSVDGI 454 >5X18-A nrPDB Length = 295 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 38/165 (23%), Positives = 75/165 (45%), Gaps = 20/165 (12%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM--EVVLLKK 95 Y++G +G G FG ++ G + + +PVAIK P T P + K Sbjct: 9 YKIGKKIGEGSFGVLFEGTNMINGVPVAIKFE-----------PRKTEAPQLRDEYKTYK 57 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITERGALQEELARSFFWQVLEA 154 + +G + + + +L+++ P ++DLFD+ + +++ + + Q++ Sbjct: 58 ILNGTPNIPYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRKFSVKTVVQVAV--QMITL 115 Query: 155 VRHCHNCGVLHRDIKDENILIDL----NRGELKLIDFGSGALLKD 195 + H +++RDIK +N LI + + LIDFG +D Sbjct: 116 IEDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRD 160 >2CMW-A nrPDB Length = 310 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 45/158 (28%), Positives = 75/158 (47%), Gaps = 21/158 (13%) Query: 39 QVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP---MEVVLLKK 95 +VG +G G FG + G + N VAIK +E P +R P +E K+ Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIK-LE----------PIKSRAPQLHLEYRFYKQ 51 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITERGALQEELARSFFWQVLEA 154 + S G+ ++ + ++LE P ++DLFD L+ L + Q+L Sbjct: 52 LGSAGEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAI--QLLSR 109 Query: 155 VRHCHNCGVLHRDIKDENILIDL--NRGE--LKLIDFG 188 + + H+ +++RD+K EN LI N+ E + +IDFG Sbjct: 110 MEYVHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFG 147 >4F0G-A nrPDB Length = 287 Score = 44.3 bits (103), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 60/271 (22%), Positives = 111/271 (40%), Gaps = 47/271 (17%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHV-------EKDRISDWGELPNGTRVPMEVVLLKKV 96 +G GGFG V+ G V D VAIK + E + I + E EV ++ + Sbjct: 27 IGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQR------EVFIMSNL 80 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQVLEAV 155 + +++L P V+ P DL+ + ++ ++ + + + Sbjct: 81 NH--PNIVKLYGLMHNPPRMVMEF---VPCGDLYHRLLDKAHPIKWSVKLRLMLDIALGI 135 Query: 156 RHCHNCG--VLHRDIKDENILI-DLNRGE---LKLIDFGSGALLKDTVY--TDFDGTRVY 207 + N ++HRD++ NI + L+ K+ DFG L + +V+ + G + Sbjct: 136 EYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFG---LSQQSVHSVSGLLGNFQW 192 Query: 208 SPPEWI-RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF---------RQ 257 PE I + A +S ++LY ++ G+ PF +E G++ F R Sbjct: 193 MAPETIGAEEESYTEKADTYSFAMILYTILTGEGPF---DEYSYGKIKFINMIREEGLRP 249 Query: 258 RVSSEC----QHLIRWCLALRPSDRPTFEEI 284 + +C +++I C + P RP F I Sbjct: 250 TIPEDCPPRLRNVIELCWSGDPKKRPHFSYI 280 >3BYV-A nrPDB Length = 377 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 39/158 (24%), Positives = 72/158 (45%), Gaps = 24/158 (15%) Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSP 209 QV+ + H+ G++H ++ +I++D RG + L F L++D +R + P Sbjct: 214 QVIRLLASLHHYGLVHTYLRPVDIVLD-QRGGVFLTGFEH--LVRDGARVVSSVSRGFEP 270 Query: 210 PEW------IRYHR----YHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR--- 256 PE I YHR S W+LG+++Y + C D+P D + + FR Sbjct: 271 PELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCADLPITKDAALGGSEWIFRSCK 330 Query: 257 ---QRVSSECQHLIRW-----CLALRPSDRPTFEEIQN 286 Q V + + +R+ L L+ + P +E+++ Sbjct: 331 NIPQPVRALLEGFLRYPKEDRLLPLQAMETPEYEQLRT 368 >1FVR-A nrPDB Length = 327 Score = 44.3 bits (103), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 65/272 (23%), Positives = 108/272 (39%), Gaps = 42/272 (15%) Query: 43 LLGSGGFGSVYSGIRVSDNLPV--AIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGF 100 ++G G FG V D L + AIK R+ ++ + E+ +L K+ Sbjct: 32 VIGEGNFGQVLKARIKKDGLRMDAAIK-----RMKEYASKDDHRDFAGELEVLCKLGH-H 85 Query: 101 SGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARS-------------- 146 +I LL E L +E P +L DF+ + L+ + A + Sbjct: 86 PNIINLLGACEHRGYLYLAIEYA-PHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQL 144 Query: 147 --FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGT 204 F V + + +HRD+ NIL+ N K+ DFG VY Sbjct: 145 LHFAADVARGMDYLSQKQFIHRDLAARNILVGENY-VAKIADFGLSR--GQEVYVKKTMG 201 Query: 205 RVYSPPEWIRY----HRYHGRSAAVWSLGILLYDMV-------CGDIPFEHDEEIIRGQV 253 R+ P W+ + + ++ VWS G+LL+++V CG E E++ +G Sbjct: 202 RL--PVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYR 259 Query: 254 FFRQ-RVSSECQHLIRWCLALRPSDRPTFEEI 284 + E L+R C +P +RP+F +I Sbjct: 260 LEKPLNCDDEVYDLMRQCWREKPYERPSFAQI 291 >4FL3-A nrPDB Length = 635 Score = 43.9 bits (102), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 48/207 (23%), Positives = 100/207 (48%), Gaps = 18/207 (8%) Query: 44 LGSGGFGSVYSG-IRVSDNLPVAIKHVEKDRISDWGELPN-GTRVPMEVVLLKKVSSGFS 101 LGSG FG+V G ++ + + K+ +D P + E +++++ + + Sbjct: 377 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAND----PALKDELLAEANVMQQLDNPY- 431 Query: 102 GVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNC 161 ++R++ E +S++L++E E + L ++ + ++++ QV +++ Sbjct: 432 -IVRMIGICE-AESWMLVMEMAE-LGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 Query: 162 GVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVY----TDFDGTRVYSPPEWIRYH 216 +HRD+ N+L+ + + K+ DFG S AL D Y T + PE I Y+ Sbjct: 489 NFVHRDLAARNVLL-VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 547 Query: 217 RYHGRSAAVWSLGILLYDMVC-GDIPF 242 ++ +S VWS G+L+++ G P+ Sbjct: 548 KFSSKS-DVWSFGVLMWEAFSYGQKPY 573 >4E20-A nrPDB Length = 290 Score = 43.9 bits (102), Expect = 9e-05, Method: Compositional matrix adjust. Identities = 41/165 (24%), Positives = 71/165 (43%), Gaps = 29/165 (17%) Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-----TVYTDF 201 F Q+ E + + H +HR + N+L+D +R +K+ DFG + + V D Sbjct: 116 FAQQICEGMAYLHAQHYIHRALAARNVLLDNDR-LVKIGDFGLAKAVPEGHEYYRVREDG 174 Query: 202 DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC----GDIPFEHDEEII-------- 249 D + PE ++ +++ ++ VWS G+ LY+++ P E+I Sbjct: 175 DSPVFWYAPECLKECKFY-YASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMT 233 Query: 250 ---------RGQVFFR-QRVSSECQHLIRWCLALRPSDRPTFEEI 284 RG+ R R E HL++ C S RPTF+ + Sbjct: 234 VLRLTELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNL 278 >2OGV-A nrPDB Length = 317 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 68/294 (23%), Positives = 122/294 (41%), Gaps = 45/294 (15%) Query: 23 TKLAPGKEKEPLESQYQVGPLLGSGGFGSVYS----GIRVSDN-LPVAIKHVEKDRISDW 77 T+L ++ E + Q G LG+G FG V G+ D L VA+K ++ +D Sbjct: 25 TQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADE 84 Query: 78 GELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG 137 E + E+ ++ + ++ LL VL++ DL +F+ + Sbjct: 85 KE-----ALMSELKIMSHLGQ-HENIVNLLGACTHGGP-VLVITEYCCYGDLLNFLRRKA 137 Query: 138 A--LQEELAR--------SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDF 187 L +E R F QV + + + +HRD+ N+L+ N K+ DF Sbjct: 138 EADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLT-NGHVAKIGDF 196 Query: 188 G-SGALLKDTVYTDFDGTRVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVC-GDIP 241 G + ++ D+ Y R+ P +W+ + + + VWS GILL+++ G P Sbjct: 197 GLARDIMNDSNYIVKGNARL--PVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNP 254 Query: 242 FEHDEEIIRGQVFFR-----------QRVSSECQHLIRWCLALRPSDRPTFEEI 284 + I+ F++ +++ C AL P+ RPTF++I Sbjct: 255 YPG---ILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 305 >2RIO-A nrPDB Length = 434 Score = 43.5 bits (101), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 47/179 (26%), Positives = 75/179 (41%), Gaps = 36/179 (20%) Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILI--------DLNRG--ELKLI--DFG----- 188 S Q+ V H H+ ++HRD+K +NIL+ D G L+++ DFG Sbjct: 119 SLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKL 178 Query: 189 -SGALLKDTVYTDFDGTRVYSPPEW------IRYHRYHGRSAAVWSLGILLYDMVC-GDI 240 SG T + GT + PE ++ R RS ++S+G + Y ++ G Sbjct: 179 DSGQSSFRTNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKH 238 Query: 241 PF----EHDEEIIRG-------QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHP 288 PF + IIRG + + + +E LI + P RPT ++ HP Sbjct: 239 PFGDKYSRESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHP 297 >5C26-A nrPDB Length = 299 Score = 43.1 bits (100), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 48/207 (23%), Positives = 100/207 (48%), Gaps = 18/207 (8%) Query: 44 LGSGGFGSVYSG-IRVSDNLPVAIKHVEKDRISDWGELPN-GTRVPMEVVLLKKVSSGFS 101 LGSG FG+V G ++ + + K+ +D P + E +++++ + + Sbjct: 35 LGSGNFGTVKKGYYQMKKVVKTVAVKILKNEAND----PALKDELLAEANVMQQLDNPY- 89 Query: 102 GVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNC 161 ++R++ E +S++L++E E + L ++ + ++++ QV +++ Sbjct: 90 -IVRMIGICE-AESWMLVMEMAE-LGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 146 Query: 162 GVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVY----TDFDGTRVYSPPEWIRYH 216 +HRD+ N+L+ + + K+ DFG S AL D Y T + PE I Y+ Sbjct: 147 NFVHRDLAARNVLL-VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 205 Query: 217 RYHGRSAAVWSLGILLYDMVC-GDIPF 242 ++ +S VWS G+L+++ G P+ Sbjct: 206 KFSSKS-DVWSFGVLMWEAFSYGQKPY 231 >5MJB-A nrPDB Length = 305 Score = 43.1 bits (100), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 40/151 (26%), Positives = 71/151 (47%), Gaps = 17/151 (11%) Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT----VYTDFDGTRV 206 + +++ +HRD+ NIL++ N K+ DFG L+D YT G ++ Sbjct: 137 IAAGMKYLSEMNYVHRDLAARNILVNSNL-VCKVSDFGLSRYLQDDTSDPTYTSSLGGKI 195 Query: 207 ---YSPPEWIRYHRYHGRSAAVWSLGILLYD-MVCGDIPF--EHDEEIIRG-QVFFRQRV 259 ++ PE I Y ++ S VWS GI++++ M G+ P+ ++++I + +R Sbjct: 196 PVRWTAPEAIAYRKFTSAS-DVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPP 254 Query: 260 SSEC----QHLIRWCLALRPSDRPTFEEIQN 286 +C L+ C + RP F EI N Sbjct: 255 PMDCPAALHQLMLDCWQKDRNSRPRFAEIVN 285 >2QKW-B nrPDB Length = 321 Score = 43.1 bits (100), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 30/89 (33%), Positives = 47/89 (52%), Gaps = 6/89 (6%) Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG---SGALLKDT-VYTDFDGTRVYSP 209 + + H ++HRD+K NIL+D N K+ DFG G L T + T GT Y Sbjct: 151 GLHYLHTRAIIHRDVKSINILLDENFVP-KITDFGISKKGTELDQTHLSTVVKGTLGYID 209 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCG 238 PE+ R +S V+S G++L++++C Sbjct: 210 PEYFIKGRLTEKS-DVYSFGVVLFEVLCA 237 >5U6B-A nrPDB Length = 307 Score = 43.1 bits (100), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 70/284 (24%), Positives = 115/284 (40%), Gaps = 59/284 (20%) Query: 40 VGPLLGSGGFGSVYSGIRVSDN--LPVAIKHVEKDRISDWGEL---------------PN 82 +G LG G FG+V G D+ L VA+K + K I EL PN Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTM-KIAICTRSELEDFLSEAVCMKEFDHPN 85 Query: 83 GTRVPMEVVLLKKVSSGFSGVIRLLDWFERPD--SFVL---ILERPE--PVQDLFDFITE 135 R+ + V F + +L + + D SF+L + ++P P Q L F+ + Sbjct: 86 VMRL-IGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMAD 144 Query: 136 RGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD 195 + E L+ F +HRD+ N +++ N + + DFG L K Sbjct: 145 IASGMEYLSTKRF---------------IHRDLAARNCMLNENMS-VCVADFG---LSKK 185 Query: 196 TVYTDF--DGTRVYSPPEWIRYH----RYHGRSAAVWSLGILLYDMVC-GDIPF---EHD 245 D+ G P +WI R + + VWS G+ ++++ G P+ E+ Sbjct: 186 IYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENS 245 Query: 246 EEIIRGQVFFRQRVSSEC----QHLIRWCLALRPSDRPTFEEIQ 285 E + R + ++C L+ C L P DRP+F E++ Sbjct: 246 EIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELR 289 >3HNG-A nrPDB Length = 360 Score = 43.1 bits (100), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 53/203 (26%), Positives = 87/203 (42%), Gaps = 33/203 (16%) Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 SSGF L D E DS E P ++DL S+ +QV + Sbjct: 169 ASSGFQEDKSLSDVEEEEDSDGFYKE-PITMEDLI---------------SYSFQVARGM 212 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDGTRVYSPPEWIR 214 + +HRD+ NIL+ N +K+ DFG + + K+ Y TR+ P +W+ Sbjct: 213 EFLSSRKCIHRDLAARNILLSEN-NVVKICDFGLARDIYKNPDYVRKGDTRL--PLKWMA 269 Query: 215 ----YHRYHGRSAAVWSLGILLYDMVC-GDIPF---EHDEEII-RGQVFFRQRV----SS 261 + + + + VWS G+LL+++ G P+ + DE+ R + R R + Sbjct: 270 PESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTP 329 Query: 262 ECQHLIRWCLALRPSDRPTFEEI 284 E ++ C P +RP F E+ Sbjct: 330 EIYQIMLDCWHRDPKERPRFAEL 352 >4XLV-A nrPDB Length = 328 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 62/278 (22%), Positives = 113/278 (40%), Gaps = 53/278 (19%) Query: 44 LGSGGFGSVYSG-----IRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSS 98 LG G FG VY G I+ VA+K V + R +E + V Sbjct: 47 LGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESA---------SLRERIEFLNEASVMK 97 Query: 99 GFSG--VIRLLDWFERPDSFVLILE--------------RPEPVQDLFDFITERGALQEE 142 GF+ V+RLL + ++++E RPE + LQE Sbjct: 98 GFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPG---RPPPTLQEM 154 Query: 143 LARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDF- 201 + + ++ + + + + +HRD+ N ++ + +K+ DFG + +D TD+ Sbjct: 155 IQMAA--EIADGMAYLNAKKFVHRDLAARNCMV-AHDFTVKIGDFG---MTRDIYETDYY 208 Query: 202 -DGTRVYSPPEWIRYHRYH----GRSAAVWSLGILLYDMVC-GDIPFE--HDEEIIR--- 250 G + P W+ S+ +WS G++L+++ + P++ +E++++ Sbjct: 209 RKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVM 268 Query: 251 --GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 G + L+R C P+ RPTF EI N Sbjct: 269 DGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVN 306 >3KUL-B nrPDB Length = 325 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 29/98 (29%), Positives = 53/98 (54%), Gaps = 8/98 (8%) Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK---DTVYTDFDGT--R 205 V +R+ + G +HRD+ N+L+D N K+ DFG +L+ D YT G Sbjct: 160 VGAGMRYLSDLGYVHRDLAARNVLVDSNL-VCKVSDFGLSRVLEDDPDAAYTTTGGKIPI 218 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF 242 ++ PE I + R ++ VWS G+++++++ G+ P+ Sbjct: 219 RWTAPEAIAF-RTFSSASDVWSFGVVMWEVLAYGERPY 255 >3BEA-A nrPDB Length = 333 Score = 42.7 bits (99), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 66/292 (22%), Positives = 116/292 (39%), Gaps = 37/292 (12%) Query: 23 TKLAPGKEKEPLESQYQVGPLLGSGGFGSVYS----GIRVSDN-LPVAIKHVEKDRISDW 77 T+L ++ E + Q G LG+G FG V G+ D L VA+K ++ +D Sbjct: 33 TQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADE 92 Query: 78 GELPNGTRVPME--------VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDL 129 E M V LL + G V+ + ++ D + + ++ Sbjct: 93 KEALMSELKIMSHLGQHENIVNLLGACTHG-GPVLVITEYCCYGDLLNFLRRKSRVLETD 151 Query: 130 FDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG- 188 F L F QV + + + +HRD+ N+L+ N K+ DFG Sbjct: 152 PAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLT-NGHVAKIGDFGL 210 Query: 189 SGALLKDTVYTDFDGTRVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVC-GDIPFE 243 + ++ D+ Y R+ P +W+ + + + VWS GILL+++ G P+ Sbjct: 211 ARDIMNDSNYIVKGNARL--PVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYP 268 Query: 244 HDEEIIRGQVFFR-----------QRVSSECQHLIRWCLALRPSDRPTFEEI 284 I+ F++ +++ C AL P+ RPTF++I Sbjct: 269 G---ILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 317 >5XD6-A nrPDB Length = 305 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 63/242 (26%), Positives = 99/242 (40%), Gaps = 31/242 (12%) Query: 27 PGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISD---WGELPNG 83 P E + Y L+G G +G V+ GI S AIK ++ + D ++ Sbjct: 13 PADELRDITDNYGSKSLIGEGSYGRVFYGILKSGK-AAAIKKLDSSKQPDQEFLAQVSMV 71 Query: 84 TRVPMEVVLLKKVSSGFSGVIRLLDWFERPD-SFVLILE--------RPEPVQDLFDFIT 134 +R+ E V+ + G +R+L + P+ S IL +P PV Sbjct: 72 SRLRQENVV-ALLGYCVDGPLRVLAYEYAPNGSLHDILHGRKGVKGAQPGPVLSWH---- 126 Query: 135 ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK 194 +R + AR LE + N V+HRDIK N+L+ + K+ DF Sbjct: 127 QRVKIAVGAARG-----LEYLHEKANPHVIHRDIKSSNVLL-FDDDVAKIADFDLSNQAP 180 Query: 195 DTVY----TDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIR 250 D T GT Y PE+ +S V+S G++L +++ G P +H + R Sbjct: 181 DMAARLHSTRVLGTFGYHAPEYAMTGTLSTKS-DVYSFGVVLLELLTGRKPVDH--TLPR 237 Query: 251 GQ 252 GQ Sbjct: 238 GQ 239 >4R7H-A nrPDB Length = 343 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 38/155 (24%), Positives = 69/155 (44%), Gaps = 23/155 (14%) Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDGTR 205 F QV + + + +HRD+ N+L+ N K+ DFG + ++ D+ Y R Sbjct: 182 FSSQVAQGMAFLASKNCIHRDVAARNVLLT-NGHVAKIGDFGLARDIMNDSNYIVKGNAR 240 Query: 206 VYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEEIIRGQVFFR---- 256 + P +W+ + + + VWS GILL+++ G P+ I+ F++ Sbjct: 241 L--PVKWMAPESIFDSVYTVQSDVWSYGILLWEIFSLGLNPYPG---ILVNSKFYKLVKD 295 Query: 257 -------QRVSSECQHLIRWCLALRPSDRPTFEEI 284 +++ C AL P+ RPTF++I Sbjct: 296 GYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 330 >5X1R-A nrPDB Length = 302 Score = 42.4 bits (98), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 67/282 (23%), Positives = 115/282 (40%), Gaps = 44/282 (15%) Query: 36 SQYQVGPLLGSGGFGSVYSG--------IRVSDNLPVAIKHVEKD-RISDWGELPNGT-- 84 +++++ +G GGFG VY I + + +P ++ D I GE T Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 85 ----RVPMEVVLLKKVS-SGFSGVIRLLDWFERPDSFV-LILERPEPVQDLFDFITERGA 138 E LL + S G V+R W E +++ +++L E+ Sbjct: 81 AGLNSFIQEARLLARFSHPGLLHVLRF--WEENGTAYMGTQFYSGTTLKNLQAQQPEK-- 136 Query: 139 LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY 198 + E R + A+ H G LHRDI +NI I ++ + L+DFGS + + Sbjct: 137 IDEAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPV-LLDFGSA---RKEIG 192 Query: 199 TDFDGTRVYSPPEWIRYHRYHGRSAA-------VWSLGILLYDMVCGDIPFEHDEEIIRG 251 D T + P + +Y S +++LG +L+ ++ G P ++R Sbjct: 193 NLSDETEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPP---PVSVVRS 249 Query: 252 -----QVFFRQRVSSECQHLIRW---CLALRPSDRP-TFEEI 284 Q +R + L+R LAL+P DRP T +E+ Sbjct: 250 IEDSYQPLTERRPAGYSPELLRTVDRALALKPEDRPQTIDEM 291 >3KRL-A nrPDB Length = 335 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 67/295 (22%), Positives = 119/295 (40%), Gaps = 41/295 (13%) Query: 23 TKLAPGKEKEPLESQYQVGPLLGSGGFGSVYS----GIRVSDN-LPVAIKHVEKDRISDW 77 T+L ++ E + Q G LG+G FG V G+ D L VA+K ++ +D Sbjct: 33 TQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADE 92 Query: 78 GELPNGTRVPME--------VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDL 129 E M V LL + G G + ++ + + L R P Sbjct: 93 KEALMSELKIMSHLGQHENIVNLLGACTHG--GPVLVITEYCCYGDLLNFLRRKRPPGLE 150 Query: 130 FDFITERGALQEELARS---FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLID 186 + + ++ +R F QV + + + +HRD+ N+L+ N K+ D Sbjct: 151 YSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLT-NGHVAKIGD 209 Query: 187 FG-SGALLKDTVYTDFDGTRVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVC-GDI 240 FG + ++ D+ Y R+ P +W+ + + + VWS GILL+++ G Sbjct: 210 FGLARDIMNDSNYIVKGNARL--PVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLN 267 Query: 241 PFEHDEEIIRGQVFFR-----------QRVSSECQHLIRWCLALRPSDRPTFEEI 284 P+ I+ F++ +++ C AL P+ RPTF++I Sbjct: 268 PYPG---ILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 319 >3G0E-A nrPDB Length = 336 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 39/153 (25%), Positives = 71/153 (46%), Gaps = 17/153 (11%) Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGT 204 SF +QV + + + +HRD+ NIL+ R K+ DFG +K D+ Y Sbjct: 172 SFSYQVAKGMAFLASKNCIHRDLAARNILLTHGR-ITKICDFGLARDIKNDSNYVVKGNA 230 Query: 205 RVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVC-GDIPF-------EHDEEIIRG- 251 R+ P +W+ ++ + + VWS GI L+++ G P+ + + I G Sbjct: 231 RL--PVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGF 288 Query: 252 QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEI 284 ++ + +E +++ C P RPTF++I Sbjct: 289 RMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQI 321 >2CHL-A nrPDB Length = 351 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 45/169 (26%), Positives = 81/169 (47%), Gaps = 25/169 (14%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP---MEVVLL 93 ++VG +G G FG + G + N VAIK +E P +R P +E Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LE----------PMKSRAPQLHLEYRFY 79 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITERGALQEELARSFFWQVL 152 K++ SG G+ ++ + ++LE P ++DLFD +L+ L + Q++ Sbjct: 80 KQLGSG-DGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAI--QLI 136 Query: 153 EAVRHCHNCGVLHRDIKDENILI----DLNRGELKLIDFGSGALLKDTV 197 + + H+ +++RD+K EN LI + + + +IDF AL K+ + Sbjct: 137 SRMEYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDF---ALAKEYI 182 >6EQI-C nrPDB Length = 433 Score = 42.0 bits (97), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 31/112 (27%), Positives = 49/112 (43%), Gaps = 27/112 (24%) Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGE----LKLIDFGSGALLKDTVYT--------D 200 EAV H + + HRD+K +NIL+DL+ G+ + + DFG K D Sbjct: 178 EAVAHMNIHNISHRDLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQD 237 Query: 201 FDGTRVYSPPE----------WIRYHRYHGRSAAVWSLGILLYDMVCGDIPF 242 G R PE W+ Y + + +W++G + Y++ D PF Sbjct: 238 KGGNRALMAPEIANAKPGTFSWLNY-----KKSDLWAVGAIAYEIFNIDNPF 284 >5L6P-A nrPDB Length = 298 Score = 41.6 bits (96), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 28/100 (28%), Positives = 52/100 (52%), Gaps = 10/100 (10%) Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT----VYTDFDGTRV 206 + +++ +HRD+ NIL++ N K+ DFG L+D YT G ++ Sbjct: 130 IAAGMKYLSEMNYVHRDLAARNILVNSNL-VCKVSDFGLSRFLEDDPSDPTYTSSLGGKI 188 Query: 207 ---YSPPEWIRYHRYHGRSAAVWSLGILLYD-MVCGDIPF 242 ++ PE I Y ++ ++ VWS GI++++ M G+ P+ Sbjct: 189 PIRWTAPEAIAYRKFTS-ASDVWSYGIVMWEVMSYGERPY 227 >4Y12-A nrPDB Length = 375 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 23/71 (32%), Positives = 41/71 (57%), Gaps = 4/71 (5%) Query: 144 ARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDG 203 A ++ ++L A+ + H+ G+++ D+K ENI+ L +LKLID G+ + + Y G Sbjct: 223 AIAYLLEILPALSYLHSIGLVYNDLKPENIM--LTEEQLKLIDLGAVSRINSFGY--LYG 278 Query: 204 TRVYSPPEWIR 214 T + PE +R Sbjct: 279 TPGFQAPEIVR 289 >2PZI-A nrPDB Length = 681 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 23/71 (32%), Positives = 41/71 (57%), Gaps = 4/71 (5%) Query: 144 ARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDG 203 A ++ ++L A+ + H+ G+++ D+K ENI+ L +LKLID G+ + + Y G Sbjct: 184 AIAYLLEILPALSYLHSIGLVYNDLKPENIM--LTEEQLKLIDLGAVSRINSFGY--LYG 239 Query: 204 TRVYSPPEWIR 214 T + PE +R Sbjct: 240 TPGFQAPEIVR 250 >4AT3-A nrPDB Length = 299 Score = 41.6 bits (96), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 43/147 (29%), Positives = 66/147 (44%), Gaps = 26/147 (17%) Query: 164 LHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---------YSPPEWIR 214 +HRD+ N L+ GE L+ G + +D TD+ RV + PPE I Sbjct: 150 VHRDLATRNCLV----GENLLVKIGDFGMSRDVYSTDY--YRVGGHTMLPIRWMPPESIM 203 Query: 215 YHRYHGRSAAVWSLGILLYDMVC-GDIPF------EHDEEIIRGQVFFRQRVS-SECQHL 266 Y ++ S VWSLG++L+++ G P+ E E I +G+V R R E L Sbjct: 204 YRKFTTESD-VWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYEL 262 Query: 267 IRWCLALRPSDRPTFEEIQNHPWMQDV 293 + C P R + I H +Q++ Sbjct: 263 MLGCWQREPHMRKNIKGI--HTLLQNL 287 >2BUJ-A nrPDB Length = 317 Score = 41.2 bits (95), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 72/268 (26%), Positives = 109/268 (40%), Gaps = 44/268 (16%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHV---------EKDRISDWGELPNGTRVPMEVVLLK 94 LG GGF V + D A+K + E R +D L N + V Sbjct: 37 LGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILRLVAYCL 96 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 + LL +F+R + I E ++D +F+TE L L + LEA Sbjct: 97 RERGAKHEAWLLLPFFKRGTLWNEI----ERLKDKGNFLTEDQILWLLLG---ICRGLEA 149 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGS---------GALLKDTVYTDFDGTR 205 + H G HRD+K NIL+ + G+ L+D GS G+ T+ D+ R Sbjct: 150 I---HAKGYAHRDLKPTNILLG-DEGQPVLMDLGSMNQACIHVEGSRQALTL-QDWAAQR 204 Query: 206 V---YSPPEW--IRYHRYHGRSAAVWSLGILLYDMVCG----DIPFEHDEEI---IRGQV 253 Y PE ++ H VWSLG +LY M+ G D+ F+ + + ++ Q+ Sbjct: 205 CTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNQL 264 Query: 254 FFRQ--RVSSECQHLIRWCLALRPSDRP 279 Q R SS L+ + + P RP Sbjct: 265 SIPQSPRHSSALWQLLNSMMTVDPHQRP 292 >4M66-A nrPDB Length = 325 Score = 41.2 bits (95), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 79/306 (25%), Positives = 124/306 (40%), Gaps = 61/306 (19%) Query: 20 LHATKLAP-GKEKEPLESQYQVGPL--LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISD 76 + + KL P G PL S+ ++ L +G GGFG V+ + N VA+K V +IS Sbjct: 1 MSSVKLWPTGASAVPLVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKIS- 59 Query: 77 WGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER 136 W E+ + E VLL GV L W FV Q L E Sbjct: 60 W-EVKAMVNLRNENVLL------LLGVTEDLQW-----DFV-------SGQALVTRFMEN 100 Query: 137 GA----LQEELARSF------FWQVLEAVRHCHNCG--VLHRDIKDENILIDLNRGELKL 184 G+ LQ E R + +V+ + + H+ +LHRD+K NIL+D KL Sbjct: 101 GSLAGLLQPEAPRPWPLLCRLLQEVVLGMCYLHSLDPPLLHRDLKPSNILLD-PELHAKL 159 Query: 185 IDFGSGAL--------LKDTVYTDFDGTRVYSPPEWI-RYHRYHGRSAAVWSLGILLYDM 235 DFG + D GT Y PE + + + +++ V+S GIL++ + Sbjct: 160 ADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAV 219 Query: 236 VCG-DIPFEHDEEIIRGQVFFRQRVS---------------SECQHLIRWCLALRPSDRP 279 + G + +IR V RQ + + L+ C + +RP Sbjct: 220 LAGREAELVDKTSLIRETVCDRQSRPPLTELPPGSPETPGLEKLKELMIHCWGSQSENRP 279 Query: 280 TFEEIQ 285 +F++ + Sbjct: 280 SFQDCE 285 >5GRN-A nrPDB Length = 356 Score = 41.2 bits (95), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 37/154 (24%), Positives = 69/154 (44%), Gaps = 25/154 (16%) Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL-KLIDFG-SGALLKDTVYTDFDG 203 SF +QV + + +HRD+ N+L L +G++ K+ DFG + ++ D+ Y Sbjct: 180 SFTYQVARGMEFLASKNCVHRDLAARNVL--LAQGKIVKICDFGLARDIMHDSNYVSKGS 237 Query: 204 TRVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEEIIRGQVFFRQ- 257 T + P +W+ + + + VWS GILL+++ G P+ ++ F+ + Sbjct: 238 T--FLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPG---MMVDSTFYNKI 292 Query: 258 ----------RVSSECQHLIRWCLALRPSDRPTF 281 +SE ++ C P RP+F Sbjct: 293 KSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSF 326 >5UIU-A nrPDB Length = 323 Score = 40.8 bits (94), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 50/205 (24%), Positives = 81/205 (39%), Gaps = 17/205 (8%) Query: 41 GPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGF 100 G +G GGFG VY G +N VA+K + EL + E+ ++ K Sbjct: 52 GNKMGEGGFGVVYKG--YVNNTTVAVKKLAAMVDITTEELKQ--QFDQEIKVMAKCQH-- 105 Query: 101 SGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA---LQEELARSFFWQVLEAVRH 157 ++ LL + D L+ P L D ++ L + + Sbjct: 106 ENLVELLGFSSDGDDLCLVYVYM-PNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINF 164 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFG----SGALLKDTVYTDFDGTRVYSPPEWI 213 H +HRDIK NIL+D K+ DFG S + + + GT Y PE + Sbjct: 165 LHENHHIHRDIKSANILLD-EAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL 223 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCG 238 R + ++S G++L +++ G Sbjct: 224 RGEIT--PKSDIYSFGVVLLEIITG 246 >2C47-A nrPDB Length = 313 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 42/160 (26%), Positives = 74/160 (46%), Gaps = 22/160 (13%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP---MEVVLL 93 ++VG +G G FG + G + N VAIK +E P +R P +E Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIK-LE----------PIKSRAPQLHLEYRFY 53 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITERGALQEELARSFFWQVL 152 K++S+ GV ++ + ++LE P ++DLFD L+ L + Q++ Sbjct: 54 KQLSAT-EGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAI--QLI 110 Query: 153 EAVRHCHNCGVLHRDIKDENILI----DLNRGELKLIDFG 188 + + H +++RD+K EN L+ + + +IDFG Sbjct: 111 TRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFG 150 >2VWV-A nrPDB Length = 302 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 41/158 (25%), Positives = 71/158 (44%), Gaps = 24/158 (15%) Query: 106 LLDWFERPDSFVL--ILERPEPVQDLFDFITERGALQEELARS-----------FFWQVL 152 ++ FE P+ L ++ PV L +F+ E GAL L + + Sbjct: 70 IMGQFEHPNIIRLEGVVTNSMPVMILTEFM-ENGALDSFLRLNDGQFTVIQLVGMLRGIA 128 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK----DTVYTDFDGTRV-- 206 +R+ +HRD+ NIL++ N K+ DFG L+ D T G ++ Sbjct: 129 SGMRYLAEMSYVHRDLAARNILVNSNL-VCKVSDFGLSRFLEENSSDPTETSSLGGKIPI 187 Query: 207 -YSPPEWIRYHRYHGRSAAVWSLGILLYD-MVCGDIPF 242 ++ PE I + ++ S A WS GI++++ M G+ P+ Sbjct: 188 RWTAPEAIAFRKFTSASDA-WSYGIVMWEVMSFGERPY 224 >5VC6-A nrPDB Length = 289 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 41/153 (26%), Positives = 61/153 (39%), Gaps = 12/153 (7%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 G K +++ +GSG FGSV+ ++ D AIK +K E + Sbjct: 3 GSMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDE-----QNA 57 Query: 88 MEVVLLKKVSSGFSGVIRLLD-WFERPDSFVLILERPEPVQDLFDFITER----GALQEE 142 + V V S V+R W E D +LI L D I+E +E Sbjct: 58 LREVYAHAVLGQHSHVVRYFSAWAE--DDHMLIQNEYCNGGSLADAISENYRIMSYFKEA 115 Query: 143 LARSFFWQVLEAVRHCHNCGVLHRDIKDENILI 175 + QV +R+ H+ ++H DIK NI I Sbjct: 116 ELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFI 148 >2W1Z-A nrPDB Length = 368 Score = 39.3 bits (90), Expect = 0.002, Method: Compositional matrix adjust. Identities = 29/108 (26%), Positives = 50/108 (46%), Gaps = 12/108 (11%) Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSP 209 Q++ + G++H D + NIL+D RG + L F L++D R ++P Sbjct: 199 QLIRLAASLQHYGLVHADFQVRNILLD-QRGGVFLTGFEH--LVRDGASAVSPIGRGFAP 255 Query: 210 PE-----WIRYHRYHGRSAA----VWSLGILLYDMVCGDIPFEHDEEI 248 PE + Y ++H W+LG+ +Y + C D+P D E+ Sbjct: 256 PETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWCADLPNTEDAEL 303 >5CLR-A nrPDB Length = 451 Score = 39.3 bits (90), Expect = 0.003, Method: Compositional matrix adjust. Identities = 31/106 (29%), Positives = 50/106 (47%), Gaps = 15/106 (14%) Query: 136 RGALQEELARSFFWQVL-------EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG 188 + AL + FW+VL V+ H G++HRD+K NI++D + + L+DFG Sbjct: 163 KNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRDLKPGNIMLDADM-QCHLVDFG 221 Query: 189 SGALLKDTVYTDFDGTRVYSPPE------WIRYHRYHGRSAAVWSL 228 S + K+ + GT Y PE +I + + A +SL Sbjct: 222 SSSSDKEPKPASW-GTASYLAPELNAQEDFIAFSQVSDLFALAYSL 266 >4NT4-A nrPDB Length = 312 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 48/183 (26%), Positives = 80/183 (43%), Gaps = 33/183 (18%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP---MEVVLL 93 ++VG +G G FG + G + +N VAIK P ++ P +E Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKME-----------PMKSKAPQLHLEYRFY 61 Query: 94 KKVSS-------GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARS 146 K + S G + L R ++ VL L ++DLF+ + +L+ L + Sbjct: 62 KLLGSHADNAPDGIPRIYHLGTCGGRYNAMVLEL-LGLSLEDLFNICARKFSLKTVLMIA 120 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE----LKLIDFGSGALLKDTVYTDFD 202 Q+L + + H+ +++RD+K EN LI + + +IDFG L K+ Y D D Sbjct: 121 --KQLLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFG---LAKE--YIDLD 173 Query: 203 GTR 205 R Sbjct: 174 TNR 176 >2WTK-B nrPDB Length = 373 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 31/117 (26%), Positives = 55/117 (47%), Gaps = 18/117 (15%) Query: 141 EELARSFFWQ-VLEAVRHCHNCGVLHRDIKDENILIDLN--------RGELKLIDFGSGA 191 ELA ++ Q VL+A+ + H+ G +HR +K +ILI ++ R L +I G Sbjct: 110 NELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQ-- 167 Query: 192 LLKDTVYTDFDGTRV-----YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE 243 + V DF V SP + + + + ++S+GI ++ G +PF+ Sbjct: 168 --RQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFK 222 >5OAT-A nrPDB Length = 411 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 31/106 (29%), Positives = 47/106 (44%), Gaps = 16/106 (15%) Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGE---LKLIDFG-------SGALLKDTVY-TDF 201 E V H G+ HRD+K +N+L+D + E L + DFG +G L T Y D Sbjct: 164 EGVAHMTAHGIAHRDLKSDNLLLDTSEPESPILVISDFGCCLADKTNGLSLPYTSYEMDK 223 Query: 202 DGTRVYSPPEWI-----RYHRYHGRSAAVWSLGILLYDMVCGDIPF 242 G PE I + + A +W++G + Y++ PF Sbjct: 224 GGNTALMAPEIICQKPGTFSVLNYSKADLWAVGAIAYEIFNCHNPF 269 >5VDK-A nrPDB Length = 297 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 43/157 (27%), Positives = 63/157 (40%), Gaps = 13/157 (8%) Query: 22 ATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELP 81 +T +A EKE LE + +G G FG+VY I+ D AIK K + EL Sbjct: 6 STNMASRYEKEFLEVEK-----IGVGEFGTVYKCIKRLDGCVYAIKRSMKT----FTELS 56 Query: 82 NGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILE--RPEPVQDLFDFITERGA- 138 N EV V V+R + D ++ E +Q T+ G Sbjct: 57 NENSALHEV-YAHAVLGHHPHVVRYYSSWAEDDHMIIQNEYCNGGSLQAAISENTKSGNH 115 Query: 139 LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILI 175 +E + Q+ + + HN ++H DIK NI I Sbjct: 116 FEEPKLKDILLQISLGLNYIHNSSMVHLDIKPSNIFI 152 >3I81-A nrPDB Length = 315 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 71/276 (25%), Positives = 115/276 (41%), Gaps = 53/276 (19%) Query: 44 LGSGGFGSVYSGIR--VSDNLP---VAIKHV-EKDRISDWGELPNGTRVPME------VV 91 LG G FG VY G+ V + P VAIK V E + + E N V E V Sbjct: 26 LGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVR 85 Query: 92 LLKKVSSGFSGVIRLLDWFERPD--SFVLILERPE----PV---QDLFDFITERGALQEE 142 LL VS G ++ +++ R D S++ L RPE PV L I G + + Sbjct: 86 LLGVVSQGQPTLV-IMELMTRGDLKSYLRSL-RPEMENNPVLAPPSLSKMIQMAGEIADG 143 Query: 143 LARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDF- 201 +A + + +HRD+ N ++ + +K+ DFG + +D TD+ Sbjct: 144 MA------------YLNANKFVHRDLAARNCMVAEDF-TVKIGDFG---MTRDIYETDYY 187 Query: 202 -DGTRVYSPPEWIRYHRYH----GRSAAVWSLGILLYDMVC-GDIPFE--HDEEIIR--- 250 G + P W+ + VWS G++L+++ + P++ +E+++R Sbjct: 188 RKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVM 247 Query: 251 --GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEI 284 G + L+R C P RP+F EI Sbjct: 248 EGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 283 >4TPT-A nrPDB Length = 303 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 60/290 (20%), Positives = 120/290 (41%), Gaps = 68/290 (23%) Query: 41 GPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGF 100 G +LG G FG + + H ++ EL + ++ F Sbjct: 5 GEVLGKGFFGQA-----------IKVTHKATGKVMVMKEL---------IRCDEETQKTF 44 Query: 101 SGVIRLLDWFERPD--SFVLILERPEPVQDLFDFITERGALQEELARS---FFWQ----- 150 ++++ + P+ F+ +L + + + L ++I E G L++ L RS F WQ Sbjct: 45 LTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYI-EGGTLKDFL-RSMDPFPWQQKVRF 102 Query: 151 ---VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL-------------- 193 + + + H+ ++HRD+ N LI L++ + + DFG L+ Sbjct: 103 AKGIASGMAYLHSMCIIHRDLNSHNCLIKLDK-TVVVADFGLSRLIVEERKRAPMEKATT 161 Query: 194 -KDTVYTDFDGTR--VYSPPEWIRYHRYHGRS----AAVWSLGILLYDMVCGDIPFEHD- 245 K T+ + R V P W+ +G+S ++S GI+L +++ G + + D Sbjct: 162 KKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII-GQVYADPDC 220 Query: 246 -----EEIIRGQVFFRQRVSSECQ----HLIRWCLALRPSDRPTFEEIQN 286 + + ++F+ + V ++C L C L P RP F ++++ Sbjct: 221 LPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLED 270 >3ZBF-A nrPDB Length = 322 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 62/287 (21%), Positives = 107/287 (37%), Gaps = 64/287 (22%) Query: 43 LLGSGGFGSVYSGIRV------SDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 LLGSG FG VY G V S + VA+K ++K G+ ++ LK+ Sbjct: 40 LLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKK-----------GSTDQEKIEFLKEA 88 Query: 97 SSGFSGVIRLLDWFERPDSF----VLILERPEPVQDLFDFITERGALQEELAR----SFF 148 L+ F P+ V +L P Q + + E G L L + +F+ Sbjct: 89 --------HLMSKFNHPNILKQLGVCLLNEP---QYIILELMEGGDLLTYLRKARMATFY 137 Query: 149 W-------------QVLEAVRHCHNCGVLHRDIKDENILIDL-NRGELKLIDFGSGALLK 194 + + + +HRD+ N L+ + + +++ G L + Sbjct: 138 GPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLAR 197 Query: 195 DTVYTDFDGTRVYS--PPEWIR----YHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEE 247 D D+ R P W+ + VWS GIL+++++ G P+ Sbjct: 198 DIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSN 257 Query: 248 I-------IRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNH 287 + G++ + + +L+ C A P RPTF IQ+ Sbjct: 258 LDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQ 304 >3DZO-A nrPDB Length = 413 Score = 37.7 bits (86), Expect = 0.007, Method: Compositional matrix adjust. Identities = 35/157 (22%), Positives = 72/157 (45%), Gaps = 23/157 (14%) Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSP 209 QV+ + H+ G++H ++ +I++D RG + L F L++D R ++P Sbjct: 219 QVIRLLASLHHYGLVHTYLRPVDIVLD-QRGGVFLTGFEH--LVRDGASAVSPIGRGFAP 275 Query: 210 PE-----WIRYHRYHGR----SAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR---- 256 PE + + ++H + W+LG+ +Y + C D+P D + + FR Sbjct: 276 PETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCADLPNTDDAALGGSEWIFRSCKN 335 Query: 257 --QRVSSECQHLIRW-----CLALRPSDRPTFEEIQN 286 Q V + + +R+ L L+ + P +E+++ Sbjct: 336 IPQPVRALLEGFLRYPKEDRLLPLQAMETPEYEQLRT 372 >4O1O-A nrPDB Length = 717 Score = 37.4 bits (85), Expect = 0.008, Method: Compositional matrix adjust. Identities = 34/119 (28%), Positives = 55/119 (46%), Gaps = 30/119 (25%) Query: 140 QEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT 199 ++E AR+ + +A+ H G H+D++ +NILID G T Sbjct: 440 EDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNG---------------TFLA 484 Query: 200 DFDGTRVYSP-PEWIRYHRYHGRSAAVWSLGIL-LYDMVCGDIPFE-----HDEEIIRG 251 DFD + ++ P+ I+ + +LG+L LY + GDI FE EE+I+G Sbjct: 485 DFDKSIKWAEDPQKIKRD--------LEALGLLVLYVVKKGDISFETLKNQSFEEVIQG 535 >6HV0-A nrPDB Length = 416 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 40/168 (23%), Positives = 68/168 (40%), Gaps = 25/168 (14%) Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDL--NRGELKLI--DFGSGALLKDTVY--- 198 + Q + H H+ ++HRD+K NILI + G++K + DFG L + Sbjct: 106 TLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFS 165 Query: 199 --TDFDGTRVYSPPEWIRYHRYHGRSAAV--WSLGILLYDMVC-GDIPFEHDEEIIRGQV 253 + GT + PE + + V +S G + Y ++ G PF + + R Sbjct: 166 RRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPF--GKSLQRQAN 223 Query: 254 FFRQRVSSECQH-----------LIRWCLALRPSDRPTFEEIQNHPWM 290 S +C H LI +A+ P RP+ + + HP+ Sbjct: 224 ILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFF 271 >5AR8-A nrPDB Length = 326 Score = 37.4 bits (85), Expect = 0.009, Method: Compositional matrix adjust. Identities = 65/272 (23%), Positives = 109/272 (40%), Gaps = 46/272 (16%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 L G G+V S + VA+KH+ E + R E +L K + FS + Sbjct: 40 LSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLR---EAEILHK--ARFSYI 94 Query: 104 IRLLDWFERPDSFVLILE-RPE-PVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNC 161 + +L P+ ++ E P + +L TE + L ++ V + HN Sbjct: 95 LPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNM 154 Query: 162 G--VLHRDIKDENILIDLNRGELKLIDFG-------SGALLKDTVYTDFDGTRVYSPPEW 212 +LH D+K +NIL+D N +K+ DFG S + + + GT +Y PPE Sbjct: 155 TPPLLHHDLKTQNILLD-NEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPE- 212 Query: 213 IRYHRYHGRSAA----VWSLGILLYDMVCGDIPFEH-------------------DEEII 249 Y A+ ++S ++ ++++ PFE +EE + Sbjct: 213 -NYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESL 271 Query: 250 RGQVFFRQRVSSECQHLIRWCLALRPSDRPTF 281 + R R+ S LI A P +RP+F Sbjct: 272 PYDIPHRARMIS----LIESGWAQNPDERPSF 299 >5DMZ-A nrPDB Length = 365 Score = 37.0 bits (84), Expect = 0.010, Method: Compositional matrix adjust. Identities = 30/116 (25%), Positives = 49/116 (42%), Gaps = 22/116 (18%) Query: 134 TERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILI-----------DLNRGEL 182 T + + L SF ++L + H+C ++H DIK +N ++ DL+ G L Sbjct: 164 TPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAG-L 222 Query: 183 KLIDFGSGALL----KDTVYT------DFDGTRVYSPPEWIRYHRYHGRSAAVWSL 228 LID G + K T++T F + S W Y G +A V+ + Sbjct: 223 ALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCM 278 >3REP-A nrPDB Length = 271 Score = 36.2 bits (82), Expect = 0.021, Method: Compositional matrix adjust. Identities = 25/114 (21%), Positives = 49/114 (42%), Gaps = 16/114 (14%) Query: 186 DFGSGALLKDTVYTDFDGTRVYSPPEWI-------RYHRYHGRSAAVWSLGILLYDMVCG 238 D + + D ++ R+Y+P W+ + + RSA +WS +LL+++V Sbjct: 149 DMTARISMADVKFSFQSPGRMYAP-AWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTR 207 Query: 239 DIPFEHDEEIIRGQVFFRQ--------RVSSECQHLIRWCLALRPSDRPTFEEI 284 ++PF + G + +S L++ C+ P+ RP F+ I Sbjct: 208 EVPFADLSNMEIGMKVALEGLRPTIPPGISPHVSKLMKICMNEDPAKRPKFDMI 261 >3MDY-A nrPDB Length = 337 Score = 35.8 bits (81), Expect = 0.023, Method: Compositional matrix adjust. Identities = 27/86 (31%), Positives = 44/86 (51%), Gaps = 12/86 (13%) Query: 162 GVLHRDIKDENILIDLNRGELKLIDFGSGA-LLKDTVYTDFD-----GTRVYSPPEWI-- 213 + HRD+K +NIL+ N G + D G + DT D GT+ Y PPE + Sbjct: 162 AIAHRDLKSKNILVKKN-GTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDE 220 Query: 214 RYHRYHGRS---AAVWSLGILLYDMV 236 +R H +S A ++S G++L+++ Sbjct: 221 SLNRNHFQSYIMADMYSFGLILWEVA 246 >4XUF-A nrPDB Length = 297 Score = 35.8 bits (81), Expect = 0.026, Method: Compositional matrix adjust. Identities = 49/229 (21%), Positives = 96/229 (41%), Gaps = 41/229 (17%) Query: 39 QVGPLLGSGGFGSV-----YSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 + G +LGSG FG V Y + ++ VA+K +++ S E + E+ ++ Sbjct: 12 EFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSERE-----ALMSELKMM 66 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILE--------------RPEPVQDLFDFITERGAL 139 ++ S ++ LL LI E R + +D ++ ++ Sbjct: 67 TQLGS-HENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLE 125 Query: 140 QEELAR--------SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SG 190 +EE F +QV + + +HRD+ N+L+ + +K+ DFG + Sbjct: 126 EEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK-VVKICDFGLAR 184 Query: 191 ALLKDTVYTDFDGTRVYSPPEWIR----YHRYHGRSAAVWSLGILLYDM 235 ++ D+ Y R+ P +W+ + + + VWS GILL+++ Sbjct: 185 DIMSDSNYVVRGNARL--PVKWMAPESLFEGIYTIKSDVWSYGILLWEI 231 >5X02-A nrPDB Length = 347 Score = 35.8 bits (81), Expect = 0.027, Method: Compositional matrix adjust. Identities = 49/229 (21%), Positives = 96/229 (41%), Gaps = 41/229 (17%) Query: 39 QVGPLLGSGGFGSV-----YSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 + G +LGSG FG V Y + ++ VA+K +++ S E + E+ ++ Sbjct: 51 EFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSERE-----ALMSELKMM 105 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILE--------------RPEPVQDLFDFITERGAL 139 ++ S ++ LL LI E R + +D ++ ++ Sbjct: 106 TQLGS-HENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFSEDEIEYENQKRLE 164 Query: 140 QEELAR--------SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SG 190 +EE F +QV + + +HRD+ N+L+ + +K+ DFG + Sbjct: 165 EEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK-VVKICDFGLAR 223 Query: 191 ALLKDTVYTDFDGTRVYSPPEWIR----YHRYHGRSAAVWSLGILLYDM 235 ++ D+ Y R+ P +W+ + + + VWS GILL+++ Sbjct: 224 DIMSDSNYVVRGNARL--PVKWMAPESLFEGIYTIKSDVWSYGILLWEI 270 >4OAU-C nrPDB Length = 699 Score = 35.4 bits (80), Expect = 0.030, Method: Compositional matrix adjust. Identities = 18/49 (36%), Positives = 31/49 (63%), Gaps = 2/49 (4%) Query: 140 QEELARSFFWQVLEAVRHCH-NCGVLHRDIKDENILIDLNRGELKLIDF 187 ++E AR+ + +AV+ H +CG H+D++ +NILID ++ L DF Sbjct: 437 EDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILID-SKKAAHLADF 484 >5J0A-A nrPDB Length = 300 Score = 35.4 bits (80), Expect = 0.034, Method: Compositional matrix adjust. Identities = 32/126 (25%), Positives = 58/126 (46%), Gaps = 11/126 (8%) Query: 127 QDLFDFITER-GALQEELARSFFWQVL----EAVRHCHN-CGVLHRDIKDENILIDLNRG 180 + L D I ER A Q+ + +V +++ H +LH DIK N++I + Sbjct: 100 KSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQEKKLLHGDIKSSNVVIKGDFE 159 Query: 181 ELKLIDFGSGALLKDTV-YTD----FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDM 235 +K+ D G L + + TD + GT + P E + + A +++ G+ L++M Sbjct: 160 TIKICDVGVSLPLDENMEVTDPEACYIGTEPWKPKEAVEENGVITDKADIFAFGLTLWEM 219 Query: 236 VCGDIP 241 + IP Sbjct: 220 MTLSIP 225 >5USZ-A nrPDB Length = 289 Score = 34.7 bits (78), Expect = 0.058, Method: Compositional matrix adjust. Identities = 34/147 (23%), Positives = 59/147 (40%), Gaps = 13/147 (8%) Query: 150 QVLEAVRHCHNCGVLHRDIKDENILI----DLNRGELKLIDFGSGALLKDTVYTDFDGTR 205 Q+ A+ ++H ++ +NIL+ D G I + + D R Sbjct: 121 QLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQER 180 Query: 206 V-YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEEIIRGQVFFRQR----- 258 + + PPE I + + WS G L+++ GD P + + Q F+ R Sbjct: 181 IPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQ-FYEDRHQLPA 239 Query: 259 -VSSECQHLIRWCLALRPSDRPTFEEI 284 ++E +LI C+ P RP+F I Sbjct: 240 PKAAELANLINNCMDYEPDHRPSFRAI 266 >2LAV-A nrPDB Length = 361 Score = 34.7 bits (78), Expect = 0.060, Method: Compositional matrix adjust. Identities = 38/168 (22%), Positives = 76/168 (45%), Gaps = 16/168 (9%) Query: 35 ESQYQVGPLLGSGGFGSVY-----SGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 89 + +++VG +G GGFG +Y S V + P +K D + EL R Sbjct: 34 KKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 93 Query: 90 VVLLKKVSS---GFSGVIR-----LLDWFERPDSFVLILERPEPVQDLFDFITERGALQE 141 + K + + + GV + L D + F+++ +Q +++ +R + + Sbjct: 94 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 153 Query: 142 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDL-NRGELKLIDFG 188 L S ++L+ + + H +H DIK N+L++ N ++ L+D+G Sbjct: 154 VLQLSL--RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 199 >2W1I-A nrPDB Length = 326 Score = 34.7 bits (78), Expect = 0.060, Method: Compositional matrix adjust. Identities = 45/205 (21%), Positives = 90/205 (43%), Gaps = 25/205 (12%) Query: 44 LGSGGFGSV----YSGIRVSDNLPVAIK---HVEKDRISDWGELPNGTRVPMEVVLLKKV 96 LG G FGSV Y ++ + VA+K H ++ + D+ E+ +LK + Sbjct: 49 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDF---------EREIEILKSL 99 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELAR-SFFWQVLEAV 155 + + + + LI+E P L D++ + + + + Q+ + + Sbjct: 100 QHDNIVKYKGVCYSAGRRNLKLIMEYL-PYGSLRDYLQKHKERIDHIKLLQYTSQICKGM 158 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDF----DGTRVYSPP 210 + +HRD+ NIL++ N +K+ DFG + L +D Y + + P Sbjct: 159 EYLGTKRYIHRDLATRNILVE-NENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAP 217 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDM 235 E + ++ ++ VWS G++LY++ Sbjct: 218 ESLTESKF-SVASDVWSFGVVLYEL 241 >3IO7-A nrPDB Length = 313 Score = 34.3 bits (77), Expect = 0.064, Method: Compositional matrix adjust. Identities = 45/205 (21%), Positives = 90/205 (43%), Gaps = 25/205 (12%) Query: 44 LGSGGFGSV----YSGIRVSDNLPVAIK---HVEKDRISDWGELPNGTRVPMEVVLLKKV 96 LG G FGSV Y ++ + VA+K H ++ + D+ E+ +LK + Sbjct: 36 LGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDF---------EREIEILKSL 86 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELAR-SFFWQVLEAV 155 + + + + LI+E P L D++ + + + + Q+ + + Sbjct: 87 QHDNIVKYKGVCYSAGRRNLKLIMEYL-PYGSLRDYLQKHKERIDHIKLLQYTSQICKGM 145 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDF----DGTRVYSPP 210 + +HRD+ NIL++ N +K+ DFG + L +D Y + + P Sbjct: 146 EYLGTKRYIHRDLATRNILVE-NENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAP 204 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDM 235 E + ++ ++ VWS G++LY++ Sbjct: 205 ESLTESKF-SVASDVWSFGVVLYEL 228 >4CI6-B nrPDB Length = 643 Score = 34.3 bits (77), Expect = 0.071, Method: Compositional matrix adjust. Identities = 14/39 (35%), Positives = 22/39 (56%) Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG 188 ++L+ H G++H DIK N++ D GE +ID G Sbjct: 164 RLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLG 202 >4RT7-A nrPDB Length = 415 Score = 34.3 bits (77), Expect = 0.079, Method: Compositional matrix adjust. Identities = 24/94 (25%), Positives = 47/94 (50%), Gaps = 8/94 (8%) Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG-SGALLKDTVYTDFDGTR 205 F +QV + + +HRD+ N+L+ + +K+ DFG + ++ D+ Y R Sbjct: 248 FAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK-VVKICDFGLARDIMSDSNYVVRGNAR 306 Query: 206 VYSPPEWIR----YHRYHGRSAAVWSLGILLYDM 235 + P +W+ + + + VWS GILL+++ Sbjct: 307 L--PVKWMAPESLFEGIYTIKSDVWSYGILLWEI 338 >2RSV-A nrPDB Length = 403 Score = 33.9 bits (76), Expect = 0.090, Method: Compositional matrix adjust. Identities = 38/168 (22%), Positives = 76/168 (45%), Gaps = 16/168 (9%) Query: 35 ESQYQVGPLLGSGGFGSVY-----SGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 89 + +++VG +G GGFG +Y S V + P +K D + EL R Sbjct: 41 KKEWKVGLPIGQGGFGCIYLADMNSSESVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKP 100 Query: 90 VVLLKKVSS---GFSGVIR-----LLDWFERPDSFVLILERPEPVQDLFDFITERGALQE 141 + K + + + GV + L D + F+++ +Q +++ +R + + Sbjct: 101 EQIQKWIRTRKLKYLGVPKYWGSGLHDKNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKT 160 Query: 142 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDL-NRGELKLIDFG 188 L S ++L+ + + H +H DIK N+L++ N ++ L+D+G Sbjct: 161 VLQLSL--RILDILEYIHEHEYVHGDIKASNLLLNYKNPDQVYLVDYG 206 >1U54-B nrPDB Length = 291 Score = 33.9 bits (76), Expect = 0.096, Method: Compositional matrix adjust. Identities = 62/262 (23%), Positives = 113/262 (43%), Gaps = 29/262 (11%) Query: 44 LGSGGFGSVYSG---IRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGF 100 LG G FG V G + VA+K ++ D +S + + R EV + + Sbjct: 26 LGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIR---EVNAMHSLDH-- 80 Query: 101 SGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA--LQEELARSFFWQVLEAVRHC 158 +IRL P + ++ P+ L D + + L L+R + QV E + + Sbjct: 81 RNLIRLYGVVLTPP--MKMVTELAPLGSLLDRLRKHQGHFLLGTLSR-YAVQVAEGMGYL 137 Query: 159 HNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYTDFDGTRV---YSPPEWI 213 + +HRD+ N+L+ R +K+ DFG L D Y + +V + PE + Sbjct: 138 ESKRFIHRDLAARNLLL-ATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL 196 Query: 214 RYHRYHGRSAAVWSLGILLYDMVC-GDIPF--EHDEEII-----RGQVFFR-QRVSSECQ 264 + R ++ W G+ L++M G P+ + +I+ G+ R + + Sbjct: 197 KT-RTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIY 255 Query: 265 HLIRWCLALRPSDRPTFEEIQN 286 +++ C A +P DRPTF +++ Sbjct: 256 NVMVQCWAHKPEDRPTFVALRD 277 >4HZS-A nrPDB Length = 341 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 62/262 (23%), Positives = 113/262 (43%), Gaps = 29/262 (11%) Query: 44 LGSGGFGSVYSG---IRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGF 100 LG G FG V G + VA+K ++ D +S + + R EV + + Sbjct: 20 LGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIR---EVNAMHSLDH-- 74 Query: 101 SGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA--LQEELARSFFWQVLEAVRHC 158 +IRL P + ++ P+ L D + + L L+R + QV E + + Sbjct: 75 RNLIRLYGVVLTPP--MKMVTELAPLGSLLDRLRKHQGHFLLGTLSR-YAVQVAEGMGYL 131 Query: 159 HNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYTDFDGTRV---YSPPEWI 213 + +HRD+ N+L+ R +K+ DFG L D Y + +V + PE + Sbjct: 132 ESKRFIHRDLAARNLLL-ATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESL 190 Query: 214 RYHRYHGRSAAVWSLGILLYDMVC-GDIPF--EHDEEII-----RGQVFFR-QRVSSECQ 264 + R ++ W G+ L++M G P+ + +I+ G+ R + + Sbjct: 191 KT-RTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIY 249 Query: 265 HLIRWCLALRPSDRPTFEEIQN 286 +++ C A +P DRPTF +++ Sbjct: 250 NVMVQCWAHKPEDRPTFVALRD 271 >4PL5-B nrPDB Length = 435 Score = 33.1 bits (74), Expect = 0.18, Method: Compositional matrix adjust. Identities = 64/278 (23%), Positives = 104/278 (37%), Gaps = 51/278 (18%) Query: 43 LLGSGGFGS-VYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS 101 +LG G G+ VY G+ DN VA+K + LP V L + S Sbjct: 34 VLGHGAEGTIVYKGM--FDNRDVAVKRI----------LPECFSFADREVQLLRESDEHP 81 Query: 102 GVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELAR------SFFWQVLEAV 155 VIR E+ F I +L + Q++ A + Q + Sbjct: 82 NVIRYF-CTEKDRQFQYI------AIELCAATLQEYVEQKDFAHLGLEPITLLHQTTSGL 134 Query: 156 RHCHNCGVLHRDIKDENILIDL--NRGELKLI--DFGSGALLKDTVYT-----DFDGTRV 206 H H+ ++HRD+K NIL+ + G +K + DFG L ++ GT Sbjct: 135 AHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEG 194 Query: 207 YSPPEWIRYHRYHGRSAAV--WSLGILLYDMVC-GDIPFEHDEEIIRGQVFFRQRVSSEC 263 + PE + + V +S G + Y ++ G PF + + R + +C Sbjct: 195 WIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPF--GKSLQRQANILLGACNLDC 252 Query: 264 QH-----------LIRWCLALRPSDRPTFEEIQNHPWM 290 H LI +A+ P RP+ + + HP+ Sbjct: 253 FHSDKHEDVIARELIEKMIAMDPQQRPSAKHVLKHPFF 290 >5ORE-A nrPDB Length = 263 Score = 32.3 bits (72), Expect = 0.28, Method: Compositional matrix adjust. Identities = 21/57 (36%), Positives = 27/57 (47%), Gaps = 5/57 (8%) Query: 21 HATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD-----NLPVAIKHVEKD 72 +AT LA EK ++ VGPL G FG V G+R D + AIK +D Sbjct: 183 NATVLAAAIEKPEMKGAKLVGPLFSGGEFGVVAVGLRKEDTALKADFDAAIKAASED 239 >5E8V-A nrPDB Length = 316 Score = 31.6 bits (70), Expect = 0.42, Method: Compositional matrix adjust. Identities = 41/153 (26%), Positives = 62/153 (40%), Gaps = 33/153 (21%) Query: 116 FVLILERPEPVQDLFDFITE---RGALQEELARSFF-WQVLE--------AVRHCHN--- 160 F+ ER + + IT +G LQE L R W+ L + H H+ Sbjct: 74 FLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHT 133 Query: 161 -CG-----VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTD------FDGTRVYS 208 CG ++HRD+K NIL+ N L DFG L T+ D GT Y Sbjct: 134 PCGRPKMPIVHRDLKSSNILVK-NDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYM 192 Query: 209 PPEWIRY-----HRYHGRSAAVWSLGILLYDMV 236 PE + + + V+S+ ++L++M Sbjct: 193 APEVLASAMNLENVESFKQTDVYSMALVLWEMT 225 >4WUA-A nrPDB Length = 401 Score = 31.6 bits (70), Expect = 0.43, Method: Compositional matrix adjust. Identities = 14/35 (40%), Positives = 22/35 (62%), Gaps = 1/35 (2%) Query: 145 RSFFWQVLEAVRHCHN-CGVLHRDIKDENILIDLN 178 + QVL+ + + H C ++H DIK ENIL+ +N Sbjct: 153 KKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVN 187 >3SOC-A nrPDB Length = 322 Score = 30.8 bits (68), Expect = 0.78, Method: Compositional matrix adjust. Identities = 28/110 (25%), Positives = 52/110 (47%), Gaps = 15/110 (13%) Query: 139 LQEELAR--SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG------SG 190 + E +AR ++ + + ++ H + HRDIK +N+L+ N + DFG +G Sbjct: 126 IAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTAC-IADFGLALKFEAG 184 Query: 191 ALLKDTVYTDFDGTRVYSPPE----WIRYHRYHGRSAAVWSLGILLYDMV 236 DT GTR Y PE I + R ++++G++L+++ Sbjct: 185 KSAGDT--HGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELA 232 >5VE6-A nrPDB Length = 492 Score = 30.0 bits (66), Expect = 1.2, Method: Compositional matrix adjust. Identities = 16/66 (24%), Positives = 31/66 (46%), Gaps = 7/66 (10%) Query: 117 VLILERPEPVQDLFDFITERGALQEELARSF-------FWQVLEAVRHCHNCGVLHRDIK 169 V+++ R P Q DF+ + A + ++ Q+ + H G++HRD+ Sbjct: 176 VVVITREVPHQTASDFVRDSAASHQAEPEAYERRVCFLLLQLCNGLEHLKEHGIIHRDLC 235 Query: 170 DENILI 175 EN+L+ Sbjct: 236 LENLLL 241 >2X7G-A nrPDB Length = 389 Score = 30.0 bits (66), Expect = 1.2, Method: Compositional matrix adjust. Identities = 14/32 (43%), Positives = 22/32 (68%), Gaps = 1/32 (3%) Query: 145 RSFFWQVLEAVRHCHN-CGVLHRDIKDENILI 175 +S QVL+ + + H+ C ++H DIK ENIL+ Sbjct: 143 KSIIRQVLQGLDYLHSKCKIIHTDIKPENILM 174 >1PY5-A nrPDB Length = 326 Score = 28.9 bits (63), Expect = 3.0, Method: Compositional matrix adjust. Identities = 22/87 (25%), Positives = 41/87 (47%), Gaps = 14/87 (16%) Query: 162 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD-------GTRVYSPPEWI- 213 + HRD+K +NIL+ N G + D G A+ D+ D GT+ Y PE + Sbjct: 154 AIAHRDLKSKNILVKKN-GTCCIADLGL-AVRHDSATDTIDIAPNHRVGTKRYMAPEVLD 211 Query: 214 ----RYHRYHGRSAAVWSLGILLYDMV 236 H + A ++++G++ +++ Sbjct: 212 DSINMKHFESFKRADIYAMGLVFWEIA 238 >3Q4U-A nrPDB Length = 301 Score = 28.9 bits (63), Expect = 3.0, Method: Compositional matrix adjust. Identities = 22/88 (25%), Positives = 41/88 (46%), Gaps = 18/88 (20%) Query: 162 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD-------GTRVYSPPEWIR 214 + HRD+K +NIL+ N G+ + D G A++ D GT+ Y PE + Sbjct: 133 AIAHRDLKSKNILVKKN-GQCCIADLGL-AVMHSQSTNQLDVGNNPRVGTKRYMAPEVLD 190 Query: 215 -------YHRYHGRSAAVWSLGILLYDM 235 + Y + +W+ G++L+++ Sbjct: 191 ETIQVDCFDSY--KRVDIWAFGLVLWEV 216 >6BFN-A nrPDB Length = 342 Score = 28.5 bits (62), Expect = 3.5, Method: Compositional matrix adjust. Identities = 24/90 (26%), Positives = 39/90 (43%), Gaps = 17/90 (18%) Query: 163 VLHRDIKDENILIDLNRGELKLIDFG-------------SGALLKDTVYTDFDGTRVYSP 209 ++H DIK N+L+D R KL DFG +++ T GT Y P Sbjct: 148 LIHGDIKSSNVLLD-ERLTPKLGDFGLARFSRFAGSSPSQSSMVART--QTVRGTLAYLP 204 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGD 239 E+I+ R +S G+++ + + G Sbjct: 205 EEYIKTGRL-AVDTDTFSFGVVVLETLAGQ 233 >3MY0-A nrPDB Length = 305 Score = 28.5 bits (62), Expect = 4.4, Method: Compositional matrix adjust. Identities = 30/127 (23%), Positives = 53/127 (41%), Gaps = 21/127 (16%) Query: 129 LFDFITERGALQEELARSFFWQVLEAVRHCH--------NCGVLHRDIKDENILIDLNRG 180 L+DF+ +R L+ LA + H H + HRD K N+L+ N Sbjct: 93 LYDFL-QRQTLEPHLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNL- 150 Query: 181 ELKLIDFGSGAL-LKDTVYTDFD-----GTRVYSPP----EWIRYHRYHG-RSAAVWSLG 229 + + D G + + + Y D GT+ Y P E IR + + +W+ G Sbjct: 151 QCCIADLGLAVMHSQGSDYLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFG 210 Query: 230 ILLYDMV 236 ++L+++ Sbjct: 211 LVLWEIA 217 >6EWX-A nrPDB Length = 484 Score = 27.3 bits (59), Expect = 7.6, Method: Compositional matrix adjust. Identities = 17/66 (25%), Positives = 30/66 (45%), Gaps = 7/66 (10%) Query: 117 VLILERPEPVQDLFDFITERGA-------LQEELARSFFWQVLEAVRHCHNCGVLHRDIK 169 V+++ R P Q DF+ + A + E Q+ + H G++HRD+ Sbjct: 178 VVVITREVPHQTASDFVRDSVASHRAEPEVYERRVCFLLLQLCNGLEHLKEHGIIHRDLC 237 Query: 170 DENILI 175 EN+L+ Sbjct: 238 LENLLL 243 >2Z01-A nrPDB Length = 348 Score = 27.3 bits (59), Expect = 8.1, Method: Compositional matrix adjust. Identities = 11/24 (45%), Positives = 17/24 (70%) Query: 125 PVQDLFDFITERGALQEELARSFF 148 P+ +FDF+ E+G+L+EE S F Sbjct: 276 PILPIFDFLREKGSLEEEEMFSVF 299 >6G4J-A nrPDB Length = 315 Score = 27.3 bits (59), Expect = 9.2, Method: Compositional matrix adjust. Identities = 19/77 (24%), Positives = 38/77 (49%), Gaps = 9/77 (11%) Query: 129 LFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG 188 L +++++GA E Q+L ++ H G + D+K +N+++ ++ ID G Sbjct: 113 LLKYVSDKGA---EWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVG 169 Query: 189 S----GALLKDTVYTDF 201 G +K+ YT+F Sbjct: 170 GTTKEGRAIKE--YTEF 184 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5TUR-A nrPDB 451 e-127 3BGP-A nrPDB 445 e-125 4RC3-A nrPDB 404 e-113 4X7Q-B nrPDB 321 2e-88 4MVF-A nrPDB 287 4e-78 5JN2-A nrPDB 285 2e-77 5ES1-A nrPDB 280 7e-76 2QNJ-A nrPDB 280 7e-76 3HZT-A nrPDB 279 2e-75 3H4J-B nrPDB 278 2e-75 4CZT-A nrPDB 277 4e-75 3MN3-A nrPDB 276 1e-74 5KZ7-A nrPDB 275 1e-74 4D28-A nrPDB 275 1e-74 4REW-A nrPDB 275 2e-74 3LIJ-A nrPDB 274 4e-74 5N23-A nrPDB 274 4e-74 3DXN-A nrPDB 273 6e-74 5X3F-B nrPDB 272 1e-73 4CFH-A nrPDB 272 2e-73 4CFF-A nrPDB 271 3e-73 4RED-A nrPDB 270 7e-73 3MA6-A nrPDB 269 8e-73 5YKS-A nrPDB 269 1e-72 3NCG-A nrPDB 269 1e-72 5EZV-A nrPDB 268 2e-72 4WB7-A nrPDB 267 4e-72 3DFA-A nrPDB 267 6e-72 4CQG-A nrPDB 265 1e-71 4D2V-A nrPDB 265 1e-71 4YZB-A nrPDB 265 2e-71 5FG8-A nrPDB 265 2e-71 2JC6-A nrPDB 264 4e-71 4FG9-A nrPDB 263 8e-71 5IG1-A nrPDB 262 1e-70 2YZA-A nrPDB 262 1e-70 2HAK-A nrPDB 261 2e-70 6C9D-A nrPDB 261 2e-70 5WAX-A nrPDB 261 3e-70 2BDW-A nrPDB 260 5e-70 3Q5I-A nrPDB 260 5e-70 2VN9-A nrPDB 259 1e-69 2VZ6-A nrPDB 259 2e-69 4RGJ-A nrPDB 258 2e-69 3KK8-A nrPDB 258 3e-69 3D2K-A nrPDB 258 3e-69 4UZD-A nrPDB 257 3e-69 5U6Y-A nrPDB 256 1e-68 3ZUT-A nrPDB 255 1e-68 2JAM-A nrPDB 255 1e-68 2JDO-A nrPDB 255 2e-68 4YNZ-A nrPDB 255 2e-68 1FOT-A nrPDB 255 2e-68 3UC3-A nrPDB 255 2e-68 2V7O-A nrPDB 255 2e-68 5KCV-A nrPDB 254 4e-68 5XZW-A nrPDB 254 5e-68 5D9K-A nrPDB 254 5e-68 2BPM-A nrPDB 254 5e-68 3BHH-A nrPDB 253 6e-68 2J90-A nrPDB 253 7e-68 2YCR-A nrPDB 253 8e-68 3MV5-A nrPDB 253 9e-68 3UDB-A nrPDB 253 9e-68 2W4O-A nrPDB 252 1e-67 4RA4-A nrPDB 252 1e-67 5JZN-A nrPDB 252 1e-67 3GUB-A nrPDB 251 2e-67 2YAB-A nrPDB 251 2e-67 2Z7Q-A nrPDB 251 3e-67 3SOA-A nrPDB 250 5e-67 3I6U-A nrPDB 250 5e-67 3F3Z-A nrPDB 250 6e-67 3TXO-A nrPDB 250 6e-67 3COM-A nrPDB 249 2e-66 2Y7J-A nrPDB 249 2e-66 1VZO-A nrPDB 248 2e-66 4C0T-A nrPDB 248 3e-66 2A27-A nrPDB 248 3e-66 1ZWS-A nrPDB 247 5e-66 4JXF-A nrPDB 247 6e-66 4PDS-A nrPDB 247 6e-66 3DB8-A nrPDB 246 8e-66 4L42-A nrPDB 246 1e-65 5F9E-A nrPDB 246 1e-65 3TAC-A nrPDB 245 1e-65 3HDN-A nrPDB 245 2e-65 4I6B-A nrPDB 245 2e-65 1PHK-A nrPDB 245 2e-65 3PFQ-A nrPDB 244 4e-65 4RLP-A nrPDB 244 4e-65 4B6L-A nrPDB 242 1e-64 3NYO-A nrPDB 242 2e-64 4CSV-A nrPDB 242 2e-64 2I0E-A nrPDB 241 3e-64 4NIF-A nrPDB 240 5e-64 4LG4-A nrPDB 240 6e-64 3IS5-A nrPDB 240 6e-64 2HW6-A nrPDB 240 7e-64 6FD3-A nrPDB 239 2e-63 2OU7-A nrPDB 239 2e-63 4B8L-A nrPDB 239 2e-63 4TNB-A nrPDB 239 2e-63 4EWQ-A nrPDB 238 2e-63 5DYK-A nrPDB 238 2e-63 6AO5-A nrPDB 238 2e-63 4QMW-A nrPDB 237 4e-63 4J52-A nrPDB 237 5e-63 4FZF-B nrPDB 237 7e-63 5FET-A nrPDB 236 9e-63 2XIK-A nrPDB 235 1e-62 4KRC-A nrPDB 235 2e-62 3C51-A nrPDB 235 2e-62 4AGU-A nrPDB 234 4e-62 5D7A-A nrPDB 234 4e-62 3A8W-A nrPDB 234 5e-62 4JG6-A nrPDB 234 6e-62 3NIZ-A nrPDB 234 6e-62 3ORZ-A nrPDB 233 7e-62 3FXW-A nrPDB 233 7e-62 6FDY-U nrPDB 233 7e-62 2X4F-A nrPDB 233 8e-62 6CMJ-A nrPDB 233 9e-62 3KN6-A nrPDB 233 1e-61 4AF3-A nrPDB 232 1e-61 3OHT-A nrPDB 232 2e-61 4YHJ-A nrPDB 231 3e-61 1G3N-A nrPDB 230 5e-61 3DLS-A nrPDB 230 5e-61 6E9W-A nrPDB 230 5e-61 5J5T-A nrPDB 230 5e-61 5LOH-A nrPDB 230 9e-61 2F9G-A nrPDB 229 9e-61 6BDL-A nrPDB 229 9e-61 3Q53-A nrPDB 229 1e-60 3DAK-A nrPDB 229 1e-60 5YV8-A nrPDB 229 1e-60 4AU8-A nrPDB 228 2e-60 1CM8-A nrPDB 228 2e-60 6GU6-A nrPDB 228 2e-60 4FIE-A nrPDB 227 6e-60 2F57-A nrPDB 226 9e-60 3UTO-A nrPDB 226 9e-60 4BBM-A nrPDB 226 1e-59 4QNY-A nrPDB 226 1e-59 4XBR-A nrPDB 226 1e-59 5DBX-A nrPDB 225 1e-59 4JDH-A nrPDB 225 2e-59 4IC8-A nrPDB 225 2e-59 2Q0N-A nrPDB 225 2e-59 6DTL-A nrPDB 225 2e-59 6ED6-A nrPDB 225 2e-59 2UV2-A nrPDB 225 2e-59 2FO0-A nrPDB 225 2e-59 4XEY-B nrPDB 224 3e-59 1KOA-A nrPDB 224 4e-59 6NPU-A nrPDB 224 4e-59 4U41-A nrPDB 224 4e-59 3OZ6-A nrPDB 224 5e-59 4FR4-A nrPDB 223 5e-59 4MYG-A nrPDB 223 5e-59 5Z33-A nrPDB 223 9e-59 4KS7-A nrPDB 223 1e-58 6QAU-A nrPDB 223 1e-58 4WNO-A nrPDB 222 1e-58 4ZSG-A nrPDB 222 1e-58 6E2O-A nrPDB 222 1e-58 2WQN-A nrPDB 222 2e-58 5EFQ-A nrPDB 221 3e-58 2BRG-A nrPDB 221 3e-58 4OTD-A nrPDB 220 4e-58 1NY3-A nrPDB 220 4e-58 3KA0-A nrPDB 220 6e-58 3GC9-A nrPDB 220 7e-58 6CKI-A nrPDB 220 7e-58 2OZA-A nrPDB 220 8e-58 1V0B-A nrPDB 219 9e-58 5O0Y-A nrPDB 219 1e-57 4UY9-A nrPDB 219 1e-57 1KOB-A nrPDB 218 2e-57 3DTC-A nrPDB 218 3e-57 5AIR-A nrPDB 218 3e-57 4NST-A nrPDB 218 3e-57 6CCF-A nrPDB 218 3e-57 2WTK-C nrPDB 218 3e-57 3GC0-A nrPDB 217 4e-57 4QTB-A nrPDB 217 5e-57 2XYN-A nrPDB 217 6e-57 5NGU-A nrPDB 217 7e-57 4APC-A nrPDB 216 1e-56 5UUU-A nrPDB 215 1e-56 6HXF-B nrPDB 215 2e-56 3PPZ-A nrPDB 215 2e-56 1UA2-A nrPDB 215 3e-56 6GQK-A nrPDB 214 3e-56 3PVW-A nrPDB 214 4e-56 3TKU-A nrPDB 214 5e-56 3HKO-A nrPDB 213 6e-56 5AWM-A nrPDB 213 6e-56 3LM0-A nrPDB 213 9e-56 4UYA-A nrPDB 212 1e-55 2OGV-A nrPDB 212 2e-55 2H8H-A nrPDB 212 2e-55 3BEA-A nrPDB 212 2e-55 6F3F-A nrPDB 212 2e-55 6CQF-A nrPDB 211 3e-55 3ZDU-A nrPDB 211 3e-55 1U5R-A nrPDB 210 4e-55 5O2C-A nrPDB 210 6e-55 6GVJ-A nrPDB 210 6e-55 4AW2-A nrPDB 210 6e-55 3KRL-A nrPDB 210 7e-55 3QGY-A nrPDB 210 8e-55 3E7O-A nrPDB 210 8e-55 2GCD-A nrPDB 209 1e-54 4E7W-A nrPDB 209 1e-54 4EBW-A nrPDB 209 1e-54 4O2Z-A nrPDB 208 2e-54 2DQ7-X nrPDB 208 2e-54 5O2B-A nrPDB 208 2e-54 2J0K-A nrPDB 208 3e-54 4CRS-A nrPDB 207 5e-54 4BGQ-A nrPDB 207 6e-54 1JNK-A nrPDB 207 6e-54 4R7H-A nrPDB 207 7e-54 3A4O-X nrPDB 207 7e-54 6BXI-A nrPDB 206 9e-54 5SYS-A nrPDB 206 9e-54 5VO2-A nrPDB 206 1e-53 4E93-A nrPDB 205 1e-53 5H2U-A nrPDB 205 1e-53 2I6L-A nrPDB 205 1e-53 5X5O-A nrPDB 205 2e-53 2XS0-A nrPDB 205 2e-53 4GS6-A nrPDB 205 2e-53 3G0E-A nrPDB 205 2e-53 3HMP-A nrPDB 204 4e-53 3FI2-A nrPDB 204 5e-53 2VD5-A nrPDB 203 5e-53 5G6V-A nrPDB 203 6e-53 2PL0-A nrPDB 203 7e-53 4XCU-A nrPDB 203 7e-53 3SXS-A nrPDB 202 2e-52 3CJF-A nrPDB 202 2e-52 4H1J-A nrPDB 202 2e-52 2ZMD-A nrPDB 202 2e-52 5AP3-A nrPDB 201 3e-52 2XNP-A nrPDB 201 4e-52 4P5Q-A nrPDB 200 5e-52 1FVR-A nrPDB 200 5e-52 3N9X-A nrPDB 200 8e-52 5Y86-A nrPDB 200 9e-52 2W96-B nrPDB 200 1e-51 3PG1-A nrPDB 199 1e-51 1TKI-A nrPDB 199 1e-51 4XI2-A nrPDB 199 1e-51 6E4F-A nrPDB 199 1e-51 4PWN-A nrPDB 198 2e-51 3ALO-A nrPDB 198 2e-51 3TT0-A nrPDB 198 3e-51 5A46-A nrPDB 198 3e-51 2HK5-A nrPDB 198 3e-51 5MJB-A nrPDB 198 3e-51 4AT3-A nrPDB 197 4e-51 1JPA-A nrPDB 197 6e-51 4EQM-A nrPDB 197 8e-51 3E3P-A nrPDB 197 8e-51 3VN9-A nrPDB 196 9e-51 4XLV-A nrPDB 196 9e-51 2PSQ-A nrPDB 196 1e-50 3GQL-A nrPDB 196 1e-50 3DKO-A nrPDB 196 1e-50 5VD3-A nrPDB 195 1e-50 4Y93-A nrPDB 195 1e-50 3ORP-A nrPDB 195 2e-50 4OLI-A nrPDB 195 2e-50 3M42-A nrPDB 195 2e-50 3MIA-A nrPDB 195 3e-50 6DBM-A nrPDB 195 3e-50 2R2P-A nrPDB 195 3e-50 3FME-A nrPDB 194 4e-50 4AN9-A nrPDB 194 4e-50 2Y6O-A nrPDB 194 4e-50 5L6P-A nrPDB 194 5e-50 3NIE-A nrPDB 193 6e-50 5HI2-A nrPDB 193 7e-50 4K33-A nrPDB 193 7e-50 4PDO-A nrPDB 193 8e-50 6O6Q-A nrPDB 192 1e-49 1LUF-A nrPDB 192 1e-49 5X8I-B nrPDB 192 2e-49 5GRN-A nrPDB 192 2e-49 5EG3-A nrPDB 192 2e-49 1K9A-A nrPDB 192 2e-49 5HIE-A nrPDB 191 3e-49 1BYG-A nrPDB 191 4e-49 6FYV-A nrPDB 189 1e-48 3PP0-A nrPDB 189 1e-48 5AMN-A nrPDB 188 2e-48 5HLW-A nrPDB 188 3e-48 2VWV-A nrPDB 188 3e-48 3BBT-B nrPDB 188 4e-48 1AD5-A nrPDB 187 4e-48 5B2L-A nrPDB 187 4e-48 3EB0-A nrPDB 187 5e-48 5ZTN-A nrPDB 187 7e-48 3KUL-B nrPDB 186 1e-47 4C59-A nrPDB 186 1e-47 4LRM-A nrPDB 186 1e-47 3LZB-A nrPDB 185 2e-47 3PLS-A nrPDB 185 2e-47 3C1X-A nrPDB 185 3e-47 4M7I-A nrPDB 184 3e-47 3RP9-A nrPDB 184 5e-47 5FM2-A nrPDB 184 5e-47 3QA8-A nrPDB 183 7e-47 3OMV-A nrPDB 183 8e-47 5GNK-A nrPDB 183 9e-47 1ZXE-A nrPDB 182 2e-46 1U59-A nrPDB 182 2e-46 4MD7-E nrPDB 182 2e-46 5KKR-C nrPDB 182 2e-46 2OZO-A nrPDB 181 3e-46 4E20-A nrPDB 181 3e-46 4F0G-A nrPDB 181 4e-46 6HMD-A nrPDB 180 5e-46 6DC0-A nrPDB 180 5e-46 5CEK-A nrPDB 180 7e-46 4KIK-B nrPDB 180 8e-46 3EQC-A nrPDB 179 1e-45 5WNO-A nrPDB 179 2e-45 5TOS-A nrPDB 178 4e-45 4X3F-A nrPDB 177 4e-45 4OW8-A nrPDB 177 4e-45 6B2Q-A nrPDB 177 5e-45 2WO6-A nrPDB 177 5e-45 5TE0-A nrPDB 177 6e-45 6EII-A nrPDB 177 6e-45 4YFF-A nrPDB 176 1e-44 2PVN-A nrPDB 176 1e-44 5U6B-A nrPDB 176 1e-44 3RAW-A nrPDB 175 3e-44 5UNP-A nrPDB 175 3e-44 4NEU-A nrPDB 175 3e-44 4IDT-A nrPDB 174 4e-44 5TQX-A nrPDB 174 4e-44 6CTH-A nrPDB 173 6e-44 1S9I-A nrPDB 173 6e-44 5XVU-A nrPDB 172 1e-43 4Y83-A nrPDB 172 2e-43 5UIU-A nrPDB 171 4e-43 4HVI-A nrPDB 170 6e-43 3LMG-A nrPDB 169 2e-42 6J5U-C nrPDB 169 2e-42 2JD5-A nrPDB 168 2e-42 4IAN-A nrPDB 168 3e-42 5IKW-A nrPDB 168 4e-42 4CRL-A nrPDB 166 9e-42 4G3E-A nrPDB 166 1e-41 2PMN-X nrPDB 166 1e-41 4FL3-A nrPDB 165 2e-41 2H34-A nrPDB 164 6e-41 5WNL-A nrPDB 164 6e-41 3UIU-A nrPDB 163 8e-41 4LFI-A nrPDB 163 9e-41 5L2Q-C nrPDB 162 2e-40 2RIO-A nrPDB 162 2e-40 5C26-A nrPDB 162 2e-40 2Y4I-B nrPDB 161 4e-40 3LLT-A nrPDB 159 1e-39 3QD2-B nrPDB 158 2e-39 5LPZ-A nrPDB 157 5e-39 5LPV-A nrPDB 156 8e-39 5XD6-A nrPDB 155 3e-38 3UIM-A nrPDB 154 5e-38 4F9B-A nrPDB 153 7e-38 3SV0-A nrPDB 153 1e-37 4EUU-A nrPDB 153 1e-37 4JLC-A nrPDB 152 1e-37 4EUT-A nrPDB 151 3e-37 5VC6-A nrPDB 151 4e-37 2BUJ-A nrPDB 150 8e-37 6O8B-A nrPDB 149 1e-36 4LQP-A nrPDB 149 2e-36 6NT9-A nrPDB 149 2e-36 4TN6-A nrPDB 148 4e-36 3VHK-A nrPDB 147 5e-36 3HNG-A nrPDB 146 1e-35 4M66-A nrPDB 146 1e-35 5FQD-C nrPDB 144 5e-35 4BTK-A nrPDB 140 7e-34 4NFN-A nrPDB 139 2e-33 4M69-B nrPDB 138 2e-33 4BTF-A nrPDB 138 3e-33 2QKW-B nrPDB 138 3e-33 5X18-A nrPDB 136 1e-32 4XHH-A nrPDB 136 1e-32 4MWI-A nrPDB 136 1e-32 1CSN-A nrPDB 130 6e-31 2CMW-A nrPDB 130 7e-31 4JRN-A nrPDB 129 2e-30 5X1R-A nrPDB 128 3e-30 4XHL-A nrPDB 127 6e-30 2CHL-A nrPDB 126 1e-29 2C47-A nrPDB 126 1e-29 2PZI-A nrPDB 119 2e-27 4Y12-A nrPDB 119 2e-27 6EQI-C nrPDB 98 4e-21 4IX6-A nrPDB 88 7e-18 3BYV-A nrPDB 81 5e-16 Sequences not found previously or not previously below threshold: 3V5Q-A nrPDB 200 7e-52 4XUF-A nrPDB 192 2e-49 5KMM-A nrPDB 191 4e-49 5X02-A nrPDB 191 4e-49 3I81-A nrPDB 184 4e-47 6FEX-A nrPDB 184 5e-47 6BSD-A nrPDB 182 2e-46 3ZBF-A nrPDB 182 3e-46 4HZS-A nrPDB 180 1e-45 6DBN-A nrPDB 178 3e-45 1U54-B nrPDB 178 4e-45 2W1I-A nrPDB 173 9e-44 3QUP-A nrPDB 172 1e-43 3IO7-A nrPDB 171 2e-43 3AOX-A nrPDB 171 2e-43 6FER-A nrPDB 171 3e-43 2A1A-B nrPDB 168 3e-42 5U6C-A nrPDB 161 4e-40 5HVK-A nrPDB 159 1e-39 3ZZW-A nrPDB 157 4e-39 4TPT-A nrPDB 157 7e-39 4PL5-B nrPDB 155 2e-38 6HV0-A nrPDB 151 3e-37 4WUA-A nrPDB 145 2e-35 5VDK-A nrPDB 144 5e-35 2X7G-A nrPDB 143 1e-34 3Q4U-A nrPDB 142 2e-34 5AR8-A nrPDB 140 1e-33 3MY0-A nrPDB 138 2e-33 3MDY-A nrPDB 136 1e-32 5J0A-A nrPDB 131 5e-31 3G2F-A nrPDB 130 9e-31 1PY5-A nrPDB 130 1e-30 5E8V-A nrPDB 128 3e-30 4RT7-A nrPDB 127 7e-30 2WTK-B nrPDB 126 1e-29 6BFN-A nrPDB 125 2e-29 4NT4-A nrPDB 118 4e-27 5USZ-A nrPDB 116 1e-26 4L00-A nrPDB 114 4e-26 3SOC-A nrPDB 114 5e-26 3REP-A nrPDB 113 1e-25 5OAT-A nrPDB 110 1e-24 2QLU-A nrPDB 110 1e-24 5C01-A nrPDB 106 1e-23 4WOV-A nrPDB 105 2e-23 5M07-A nrPDB 104 6e-23 4I94-A nrPDB 99 3e-21 5UU1-A nrPDB 95 5e-20 5UV4-A nrPDB 91 6e-19 2RSV-A nrPDB 91 8e-19 2LAV-A nrPDB 90 2e-18 4L68-A nrPDB 82 3e-16 6J6I-B nrPDB 80 2e-15 4O1O-A nrPDB 78 4e-15 4CI6-B nrPDB 75 5e-14 6BHC-A nrPDB 74 8e-14 5CLR-A nrPDB 74 9e-14 4OAU-C nrPDB 73 2e-13 5DMZ-A nrPDB 72 3e-13 3DZO-A nrPDB 71 6e-13 6G4J-A nrPDB 70 1e-12 6EAS-A nrPDB 70 1e-12 2W1Z-A nrPDB 65 4e-11 6EWX-A nrPDB 63 2e-10 6M7Z-A nrPDB 60 2e-09 2JII-A nrPDB 58 5e-09 5GZA-A nrPDB 54 1e-07 5GZ9-A nrPDB 53 2e-07 4CZY-B nrPDB 51 8e-07 3ENH-A nrPDB 51 8e-07 4CYJ-A nrPDB 50 1e-06 6G38-A nrPDB 49 2e-06 4AZV-A nrPDB 49 2e-06 4AZW-A nrPDB 49 2e-06 4WWA-A nrPDB 47 1e-05 4BWP-A nrPDB 46 2e-05 5VE6-A nrPDB 45 4e-05 6R5K-O nrPDB 45 5e-05 4XR7-L nrPDB 43 1e-04 3Q60-A nrPDB 39 0.002 5I35-A nrPDB 38 0.005 4BVU-A nrPDB 37 0.014 5YK0-A nrPDB 36 0.022 6FAI-l nrPDB 36 0.026 1TQM-A nrPDB 35 0.032 6G18-v nrPDB 35 0.042 6DFL-A nrPDB 35 0.044 6FDN-A nrPDB 34 0.10 4H05-A nrPDB 32 0.29 >5TUR-A nrPDB Length = 404 Score = 451 bits (1160), Expect = e-127, Method: Composition-based stats. Identities = 313/313 (100%), Positives = 313/313 (100%) Query: 1 MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD 60 MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD Sbjct: 92 MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD 151 Query: 61 NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL 120 NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL Sbjct: 152 NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL 211 Query: 121 ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG 180 ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG Sbjct: 212 ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG 271 Query: 181 ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI 240 ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI Sbjct: 272 ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI 331 Query: 241 PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA 300 PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA Sbjct: 332 PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA 391 Query: 301 EIHLHSLSPGPSK 313 EIHLHSLSPGPSK Sbjct: 392 EIHLHSLSPGPSK 404 >3BGP-A nrPDB Length = 333 Score = 445 bits (1144), Expect = e-125, Method: Composition-based stats. Identities = 313/313 (100%), Positives = 313/313 (100%) Query: 1 MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD 60 MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD Sbjct: 21 MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD 80 Query: 61 NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL 120 NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL Sbjct: 81 NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL 140 Query: 121 ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG 180 ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG Sbjct: 141 ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG 200 Query: 181 ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI 240 ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI Sbjct: 201 ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI 260 Query: 241 PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA 300 PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA Sbjct: 261 PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA 320 Query: 301 EIHLHSLSPGPSK 313 EIHLHSLSPGPSK Sbjct: 321 EIHLHSLSPGPSK 333 >4RC3-A nrPDB Length = 289 Score = 404 bits (1039), Expect = e-113, Method: Composition-based stats. Identities = 285/285 (100%), Positives = 285/285 (100%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM Sbjct: 5 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 64 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 148 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF Sbjct: 65 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 124 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYS 208 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYS Sbjct: 125 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYS 184 Query: 209 PPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIR 268 PPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIR Sbjct: 185 PPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIR 244 Query: 269 WCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK 313 WCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK Sbjct: 245 WCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK 289 >4X7Q-B nrPDB Length = 312 Score = 321 bits (823), Expect = 2e-88, Method: Composition-based stats. Identities = 166/285 (58%), Positives = 205/285 (71%), Gaps = 5/285 (1%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 K++E E++Y++GPLLG GGFG+V++G R++D L VAIK + ++R+ W L + P+ Sbjct: 24 KDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPL 83 Query: 89 EVVLLKKVSSG--FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARS 146 EV LL KV +G GVIRLLDWFE + F+L+LERP P QDLFD+ITE+G L E +R Sbjct: 84 EVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRC 143 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV 206 FF QV+ A++HCH+ GV+HRDIKDENILIDL RG KLIDFGSGALL D YTDFDGTRV Sbjct: 144 FFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRV 203 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHL 266 YSPPEWI H+YH A VWSLGILLYDMVCGDIPFE D+EI+ ++ F VS +C L Sbjct: 204 YSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCAL 263 Query: 267 IRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGP 311 IR CLA +PS RP+ EEI PWMQ P E ++ P P Sbjct: 264 IRRCLAPKPSSRPSLEEILLDPWMQT---PAEDVPLNPSKGGPAP 305 >4MVF-A nrPDB Length = 506 Score = 287 bits (735), Expect = 4e-78, Method: Composition-based stats. Identities = 86/283 (30%), Positives = 139/283 (49%), Gaps = 24/283 (8%) Query: 33 PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVL 92 LE +Y + LG G +G VY GI N AIK +KDR L N R E+ + Sbjct: 54 KLEDKYIIDEKLGQGTYGCVYKGIDKVTNQLYAIKEEKKDR------LKNINRFFQEIEI 107 Query: 93 LKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 +KK+ +++L + +E + LI+E +LFD I E G+ E+ A + Q+ Sbjct: 108 MKKLDH--PNIVKLYETYENDNYIYLIMELCSGR-ELFDSIIENGSFTEKNAATIMKQIF 164 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGE--LKLIDFGSGALL-KDTVYTDFDGTRVYSP 209 A+ + H+ ++HRD+K EN L + LK+IDFG L T GT Y Sbjct: 165 SAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIIDFGLSKNLGTGEFTTTKAGTPYYVA 224 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQR----V 259 P+ + + + +WS G+++Y ++CG PF D +++ +G+ F + + Sbjct: 225 PQVLDGK--YDKKCDIWSSGVIMYTLLCGYPPFYGDTDNEVLKKVKKGEFCFYENDWGSI 282 Query: 260 SSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEI 302 SS+ ++LI L P++R T EE NHPW+ + E E+ Sbjct: 283 SSDAKNLITKLLTYNPNERCTIEEALNHPWITQMTKSHEHVEL 325 >5JN2-A nrPDB Length = 525 Score = 285 bits (730), Expect = 2e-77, Method: Composition-based stats. Identities = 81/312 (25%), Positives = 135/312 (43%), Gaps = 24/312 (7%) Query: 10 AHLRAAPCNDLHAT-KLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKH 68 A P + LHAT + +Y+ +LG G FG V A+K Sbjct: 40 AGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKV 99 Query: 69 VEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQD 128 + K ++ + + + EV LLK++ +++L ++FE F L+ E + Sbjct: 100 ISKRQV---KQKTDKESLLREVQLLKQLDH--PNIMKLYEFFEDKGYFYLVGEVYTG-GE 153 Query: 129 LFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILID--LNRGELKLID 186 LFD I R E A QVL + + H ++HRD+K EN+L++ +++ID Sbjct: 154 LFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIID 213 Query: 187 FGSGALLK-DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH- 244 FG + D GT Y PE + + VWS G++LY ++ G PF Sbjct: 214 FGLSTHFEASKKMKDKIGTAYYIAPEVLHGT--YDEKCDVWSTGVILYILLSGCPPFNGA 271 Query: 245 -----DEEIIRGQVFFR----QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLL 295 +++ +G+ F ++VS + LIR L PS R + + +H W+Q Sbjct: 272 NEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYT- 330 Query: 296 PQETAEIHLHSL 307 +E + + SL Sbjct: 331 -KEQISVDVPSL 341 >5ES1-A nrPDB Length = 328 Score = 280 bits (716), Expect = 7e-76, Method: Composition-based stats. Identities = 76/291 (26%), Positives = 143/291 (49%), Gaps = 15/291 (5%) Query: 22 ATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELP 81 +A E++P Y++ +G G F V + VAIK ++K ++ Sbjct: 1 GNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQL----NPS 56 Query: 82 NGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQE 141 + ++ EV ++K ++ +++L + E + L++E ++FD++ G ++E Sbjct: 57 SLQKLFREVRIMKGLNH--PNIVKLFEVIETEKTLYLVMEYAS-AGEVFDYLVSHGRMKE 113 Query: 142 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTD 200 + AR+ F Q++ AV +CH ++HRD+K EN+L+D +K+ DFG + Sbjct: 114 KEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEAN-IKIADFGFSNEFTLGSKLDT 172 Query: 201 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH------DEEIIRGQVF 254 F G+ Y+ PE + +Y G +WSLG++LY +V G +PF+ E ++RG+ Sbjct: 173 FCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYR 232 Query: 255 FRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLH 305 +S++C+ ++R L L P+ R T E+I W+ +E Sbjct: 233 VPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEP 283 >2QNJ-A nrPDB Length = 328 Score = 280 bits (716), Expect = 7e-76, Method: Composition-based stats. Identities = 81/295 (27%), Positives = 145/295 (49%), Gaps = 15/295 (5%) Query: 26 APGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTR 85 A G +++P Y++ +G G F V + VAIK ++K ++ + + Sbjct: 2 AMGSDEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQL----NPTSLQK 57 Query: 86 VPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELAR 145 + EV ++K ++ +++L + E + LI+E ++FD++ G ++E+ AR Sbjct: 58 LFREVRIMKILNH--PNIVKLFEVIETEKTLYLIMEYASG-GEVFDYLVAHGRMKEKEAR 114 Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGT 204 S F Q++ AV++CH ++HRD+K EN+L+D + +K+ DFG F G+ Sbjct: 115 SKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMN-IKIADFGFSNEFTVGGKLDTFCGS 173 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH------DEEIIRGQVFFRQR 258 Y+ PE + +Y G VWSLG++LY +V G +PF+ E ++RG+ Sbjct: 174 PPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFY 233 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK 313 +S++C++L++ L L P R T E+I W+ E L K Sbjct: 234 MSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQK 288 >3HZT-A nrPDB Length = 467 Score = 279 bits (713), Expect = 2e-75, Method: Composition-based stats. Identities = 84/288 (29%), Positives = 139/288 (48%), Gaps = 22/288 (7%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 L +YQ LGSG +G V AIK ++K ++ N + EV +L Sbjct: 2 LSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTS---NSGALLDEVAVL 58 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 K++ +++L ++FE ++ L++E +LFD I R E A QVL Sbjct: 59 KQLDH--PNIMKLYEFFEDKRNYYLVMEVYRG-GELFDEIILRQKFSEVDAAVIMKQVLS 115 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRGE--LKLIDFGSGALLK-DTVYTDFDGTRVYSPP 210 + H ++HRD+K EN+L++ + +K++DFG A + + GT Y P Sbjct: 116 GTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYIAP 175 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHDEEII----RGQVFFRQR----VS 260 E +R + + VWS G++LY ++CG PF + D+EI+ +G+ F VS Sbjct: 176 EVLR--KKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQVS 233 Query: 261 SECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLS 308 E + L++ L PS R + EE NHPW+ Q+ ++ H+L+ Sbjct: 234 DEAKQLVKLMLTYEPSKRISAEEALNHPWIVK-FCSQKHTDVGKHALT 280 >3H4J-B nrPDB Length = 336 Score = 278 bits (712), Expect = 2e-75, Method: Composition-based stats. Identities = 82/275 (29%), Positives = 127/275 (46%), Gaps = 19/275 (6%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 Y + LG G FG V VA+K + + + RV E+ LK + Sbjct: 11 YIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKKSD---MHMRVEREISYLKLLR 67 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 +I+L D P V+++E +LFD+I E+ + E+ R FF Q++ A+ + Sbjct: 68 H--PHIIKLYDVITTPTDIVMVIEYAG--GELFDYIVEKKRMTEDEGRRFFQQIICAIEY 123 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPEWIRYH 216 CH ++HRD+K EN+L+D N +K+ DFG ++ D G+ Y+ PE I Sbjct: 124 CHRHKIVHRDLKPENLLLDDNLN-VKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVINGK 182 Query: 217 RYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRWC 270 Y G VWS GI+LY M+ G +PF+ + +++ +S Q LIR Sbjct: 183 LYAGPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNSCVYVMPDFLSPGAQSLIRRM 242 Query: 271 LALRPSDRPTFEEIQNHPWMQ----DVLLPQETAE 301 + P R T +EI+ PW D L P E + Sbjct: 243 IVADPMQRITIQEIRRDPWFNVNLPDYLRPMEEVQ 277 >4CZT-A nrPDB Length = 464 Score = 277 bits (709), Expect = 4e-75, Method: Composition-based stats. Identities = 87/284 (30%), Positives = 142/284 (50%), Gaps = 19/284 (6%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +Y++G LG G F V V + VAIK ++K+++ + ++ E+ +K Sbjct: 11 GKYELGRTLGEGTFAKVKFARNVENGDNVAIKVIDKEKVLKNKMI---AQIKREISTMKL 67 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 + VIR+ + +LE +LFD I+ G L+E+ AR +F Q++ AV Sbjct: 68 IKH--PNVIRMFEVMASKTKIYFVLEFVTG-GELFDKISSNGRLKEDEARKYFQQLINAV 124 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL----KDTVYTDFDGTRVYSPPE 211 +CH+ GV HRD+K EN+L+D N G LK+ DFG AL +D + GT Y PE Sbjct: 125 DYCHSRGVYHRDLKPENLLLDAN-GALKVSDFGLSALPQQVREDGLLHTTCGTPNYVAPE 183 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQH 265 I Y G A +WS G++L+ ++ G +PFE ++I + + S+ + Sbjct: 184 VINNKGYDGAKADLWSCGVILFVLMAGYLPFEDSNLTSLYKKIFKAEFTCPPWFSASAKK 243 Query: 266 LIRWCLALRPSDRPTFEEIQNHPWMQD-VLLPQ-ETAEIHLHSL 307 LI+ L P+ R TF E+ + W + P+ E A++ L + Sbjct: 244 LIKRILDPNPATRITFAEVIENEWFKKGYKAPKFENADVSLDDV 287 >3MN3-A nrPDB Length = 271 Score = 276 bits (706), Expect = 1e-74, Method: Composition-based stats. Identities = 80/276 (28%), Positives = 132/276 (47%), Gaps = 16/276 (5%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 YQ+ LG G FG V + VA+K + K ++ R+ E+ L+ Sbjct: 4 GNYQIVKTLGEGSFGKVKLAYHTTTGQKVALKIINKKVLAKSD---MQGRIEREISYLRL 60 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 + +I+L D + D ++++E +LFD+I +R + E+ AR FF Q++ AV Sbjct: 61 LRH--PHIIKLYDVIKSKDEIIMVIEYAGN--ELFDYIVQRDKMSEQEARRFFQQIISAV 116 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPEWIR 214 +CH ++HRD+K EN+L+D + +K+ DFG ++ D G+ Y+ PE I Sbjct: 117 EYCHRHKIVHRDLKPENLLLDEHLN-VKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVIS 175 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIR 268 Y G VWS G++LY M+C +PF+ + + I G + +S LI+ Sbjct: 176 GKLYAGPEVDVWSCGVILYVMLCRRLPFDDESIPVLFKNISNGVYTLPKFLSPGAAGLIK 235 Query: 269 WCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHL 304 L + P +R + EI W + V LP+ L Sbjct: 236 RMLIVNPLNRISIHEIMQDDWFK-VDLPEYLLPPDL 270 >5KZ7-A nrPDB Length = 346 Score = 275 bits (705), Expect = 1e-74, Method: Composition-based stats. Identities = 78/289 (26%), Positives = 150/289 (51%), Gaps = 16/289 (5%) Query: 26 APGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTR 85 A +++P Y++ +G G F V + VA+K ++K +++ + + Sbjct: 23 ATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNS----SSLQK 78 Query: 86 VPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELAR 145 + EV ++K ++ +++L + E + L++E ++FD++ G ++E+ AR Sbjct: 79 LFREVRIMKVLNH--PNIVKLFEVIETEKTLYLVMEYASG-GEVFDYLVAHGRMKEKEAR 135 Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGT 204 + F Q++ AV++CH ++HRD+K EN+L+D + +K+ DFG F G+ Sbjct: 136 AKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMN-IKIADFGFSNEFTFGNKLDTFCGS 194 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH------DEEIIRGQVFFRQR 258 Y+ PE + +Y G VWSLG++LY +V G +PF+ E ++RG+ Sbjct: 195 PPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFY 254 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSL 307 +S++C++L++ L L PS R T E+I WM +V + + ++ L Sbjct: 255 MSTDCENLLKKFLILNPSKRGTLEQIMKDRWM-NVGHEDDELKPYVEPL 302 >4D28-A nrPDB Length = 446 Score = 275 bits (704), Expect = 1e-74, Method: Composition-based stats. Identities = 85/283 (30%), Positives = 139/283 (49%), Gaps = 18/283 (6%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +Y+VG +G G F V VAIK + K I + ++ E+ ++K Sbjct: 9 GKYEVGRTIGEGTFAKVKFARNTDTGDNVAIKIMAKSTILKNRMVD---QIKREISIMKI 65 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 V ++RL + ++LE +LFD I +G L+E+ +R +F Q+++AV Sbjct: 66 VRH--PNIVRLYEVLASKSKIYIVLEFVTG-GELFDRIVHKGRLKEDESRKYFQQLVDAV 122 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD--TVYTDFDGTRVYSPPEWI 213 HCH+ GV HRD+K EN+L+D N G LK+ DFG AL ++ + D GT Y PE + Sbjct: 123 AHCHSKGVYHRDLKPENLLLDTN-GNLKVSDFGLSALPQEGVELLNDTCGTPNYVAPEVL 181 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EIIRGQVFFRQRVSSECQHLI 267 Y G +A +WS G++L+ ++ G +PF + +I + S+E + LI Sbjct: 182 SGQGYDGSAADIWSCGVILFVILAGYLPFSETDLPGLYRKINAAEFDCPPWFSAEVKFLI 241 Query: 268 RWCLALRPSDRPTFEEIQNHPWMQDVLLP---QETAEIHLHSL 307 L P R + I+ PW + +P +E E++L + Sbjct: 242 HRILDPNPKTRIQIQGIKKDPWFRKNYVPIRAREEEEVNLDDI 284 >4REW-A nrPDB Length = 540 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 77/274 (28%), Positives = 130/274 (47%), Gaps = 18/274 (6%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 Y +G LG G FG V G VA+K + + +I + ++ E+ LK Sbjct: 6 GHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVV---GKIRREIQNLKL 62 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 +I+L P +++E +LFD+I + G L E+ +R F Q+L V Sbjct: 63 FRH--PHIIKLYQVISTPSDIFMVMEYVSG-GELFDYICKNGRLDEKESRRLFQQILSGV 119 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPEWIR 214 +CH V+HRD+K EN+L+D + K+ DFG ++ D G+ Y+ PE I Sbjct: 120 DYCHRHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 178 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIR 268 Y G +WS G++LY ++CG +PF+ D ++I G + Q ++ L++ Sbjct: 179 GRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLK 238 Query: 269 WCLALRPSDRPTFEEIQNHPWMQD----VLLPQE 298 L + P R + ++I+ H W + L P++ Sbjct: 239 HMLQVDPMKRASIKDIREHEWFKQDLPKYLFPED 272 >3LIJ-A nrPDB Length = 494 Score = 274 bits (701), Expect = 4e-74, Method: Composition-based stats. Identities = 83/293 (28%), Positives = 144/293 (49%), Gaps = 23/293 (7%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 +K L YQ LGSG +G V ++ AIK + K +S +++ Sbjct: 30 SKKGHLSEMYQRVKKLGSGAYGEVLLCRDKVTHVERAIKIIRKTSVSTSSN----SKLLE 85 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 148 EV +LK + +++L D+FE ++ L++E +LFD I R E A Sbjct: 86 EVAVLKLLDH--PNIMKLYDFFEDKRNYYLVME-CYKGGELFDEIIHRMKFNEVDAAVII 142 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE--LKLIDFGSGALLKDT-VYTDFDGTR 205 QVL V + H ++HRD+K EN+L++ + +K++DFG A+ ++ + GT Sbjct: 143 KQVLSGVTYLHKHNIVHRDLKPENLLLESKEKDALIKIVDFGLSAVFENQKKMKERLGTA 202 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHDEEIIR----GQVFFR--- 256 Y PE +R + + VWS+G++L+ ++ G PF + D+EI+R G+ F Sbjct: 203 YYIAPEVLR--KKYDEKCDVWSIGVILFILLAGYPPFGGQTDQEILRKVEKGKYTFDSPE 260 Query: 257 -QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLS 308 + VS + LI+ L R + ++ HPW++++ +E + I L SL+ Sbjct: 261 WKNVSEGAKDLIKQMLQFDSQRRISAQQALEHPWIKEMCSKKE-SGIELPSLA 312 >5N23-A nrPDB Length = 352 Score = 274 bits (701), Expect = 4e-74, Method: Composition-based stats. Identities = 76/301 (25%), Positives = 136/301 (45%), Gaps = 20/301 (6%) Query: 4 SKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLP 63 S+ S+ A D +P + L Q++ LG+G FG V Sbjct: 11 SEQESVKEFLAKAKEDFLKKWESPAQNTAHL-DQFERIRTLGTGSFGRVMLVKHKETGNH 69 Query: 64 VAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERP 123 A+K ++K ++ ++ + E + + V+ F +++L F+ + ++LE Sbjct: 70 YAMKILDKQKVVKLKQIEH---TLNEKRIQQAVN--FPFLVKLEFSFKDNSNLYMVLEYA 124 Query: 124 EPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELK 183 P ++F + G E AR + Q++ + H+ +++RD+K EN+LID +G +K Sbjct: 125 -PGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYIK 182 Query: 184 LIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE 243 + DFG +K GT Y PE I Y+ ++ W+LG+L+Y+M G PF Sbjct: 183 VADFGFAKRVKGRTPWTLCGTPEYLAPEIILSKGYN-KAVDWWALGVLIYEMAAGYPPFF 241 Query: 244 HDE------EIIRGQVFFRQRVSSECQHLIRWCLALRPSDR-----PTFEEIQNHPWMQD 292 D+ +I+ G+V F SS+ + L+R L + + R +I+NH W Sbjct: 242 ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 301 Query: 293 V 293 Sbjct: 302 T 302 >3DXN-A nrPDB Length = 287 Score = 273 bits (699), Expect = 6e-74, Method: Composition-based stats. Identities = 81/272 (29%), Positives = 132/272 (48%), Gaps = 21/272 (7%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVV 91 + L +YQ LGSG +G V AIK ++K ++ N + EV Sbjct: 17 QGLSDRYQRVKKLGSGAYGEVLLCKDKLTGAERAIKIIKKSSVTTTS---NSGALLDEVA 73 Query: 92 LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQV 151 +LK++ +++L ++FE ++ L++E +LFD I R E A QV Sbjct: 74 VLKQLDH--PNIMKLYEFFEDKRNYYLVMEVYRG-GELFDEIILRQKFSEVDAAVIMKQV 130 Query: 152 LEAVRHCHNCGVLHRDIKDENILIDLNRGE--LKLIDFGSGALLK-DTVYTDFDGTRVYS 208 L + H ++HRD+K EN+L++ + +K++DFG A + + GT Y Sbjct: 131 LSGTTYLHKHNIVHRDLKPENLLLESKSRDALIKIVDFGLSAHFEVGGKMKERLGTAYYI 190 Query: 209 PPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHDEEII----RGQVFFRQR---- 258 PE +R + + VWS G++LY ++CG PF + D+EI+ +G+ F Sbjct: 191 APEVLR--KKYDEKCDVWSCGVILYILLCGYPPFGGQTDQEILKRVEKGKFSFDPPDWTQ 248 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 VS E + L++ L PS R + EE NHPW+ Sbjct: 249 VSDEAKQLVKLMLTYEPSKRISAEEALNHPWI 280 >5X3F-B nrPDB Length = 393 Score = 272 bits (696), Expect = 1e-73, Method: Composition-based stats. Identities = 75/301 (24%), Positives = 136/301 (45%), Gaps = 21/301 (6%) Query: 4 SKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLP 63 K+N + A D P + L Q+ LG+G FG V Sbjct: 53 KKLNDVQAFLAKAKEDFLKKWETPSQNTAQL-DQFDRIKTLGTGSFGRVMLVKHKESGNH 111 Query: 64 VAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERP 123 A+K ++K ++ ++ + E +L+ V+ F +++L F+ + +++E Sbjct: 112 YAMKILDKQKVVKLKQIEH---TLNEKRILQAVN--FPFLVKLEFSFKDNSNLYMVMEYV 166 Query: 124 EPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELK 183 ++F + G E AR + Q++ + H+ +++RD+K EN+LID +G ++ Sbjct: 167 AG-GEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYIQ 224 Query: 184 LIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE 243 + DFG +K +T GT Y PE I Y+ ++ W+LG+L+Y+M G PF Sbjct: 225 VTDFGFAKRVKGRTWT-LCGTPEYLAPEIILSKGYN-KAVDWWALGVLIYEMAAGYPPFF 282 Query: 244 HDE------EIIRGQVFFRQRVSSECQHLIRWCLALRPSDR-----PTFEEIQNHPWMQD 292 D+ +I+ G+V F SS+ + L+R L + + R +I+NH W Sbjct: 283 ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT 342 Query: 293 V 293 Sbjct: 343 T 343 >4CFH-A nrPDB Length = 493 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 81/288 (28%), Positives = 136/288 (47%), Gaps = 23/288 (7%) Query: 27 PGKEKEPLESQ-----YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELP 81 P EK+ + + Y +G LG G FG V G VA+K + + +I + Sbjct: 19 PMAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVV- 77 Query: 82 NGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQE 141 ++ E+ LK +I+L P +++E +LFD+I + G L E Sbjct: 78 --GKIRREIQNLKLFRH--PHIIKLYQVISTPSDIFMVMEYVSG-GELFDYICKNGRLDE 132 Query: 142 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-TVYTD 200 + +R F Q+L V +CH V+HRD+K EN+L+D + K+ DFG ++ D Sbjct: 133 KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDGEFLRT 191 Query: 201 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVF 254 G+ Y+ PE I Y G +WS G++LY ++CG +PF+ D ++I G + Sbjct: 192 SCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFY 251 Query: 255 FRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD----VLLPQE 298 Q ++ L++ L + P R T ++I+ H W + L P++ Sbjct: 252 TPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPED 299 >4CFF-A nrPDB Length = 571 Score = 271 bits (693), Expect = 3e-73, Method: Composition-based stats. Identities = 81/288 (28%), Positives = 137/288 (47%), Gaps = 23/288 (7%) Query: 27 PGKEKEPLESQ-----YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELP 81 P EK+ + + Y +G LG G FG V G VA+K + + +I + Sbjct: 19 PMAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVV- 77 Query: 82 NGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQE 141 ++ E+ LK +I+L P F +++E +LFD+I + G ++E Sbjct: 78 --GKIKREIQNLKLFRH--PHIIKLYQVISTPTDFFMVMEYVSG-GELFDYICKHGRVEE 132 Query: 142 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-TVYTD 200 AR F Q+L AV +CH V+HRD+K EN+L+D + K+ DFG ++ D Sbjct: 133 MEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDGEFLRT 191 Query: 201 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVF 254 G+ Y+ PE I Y G +WS G++LY ++CG +PF+ + ++I G + Sbjct: 192 SCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFY 251 Query: 255 FRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD----VLLPQE 298 + ++ L+ L + P R T ++I+ H W + L P++ Sbjct: 252 IPEYLNRSVATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPED 299 >4RED-A nrPDB Length = 351 Score = 270 bits (690), Expect = 7e-73, Method: Composition-based stats. Identities = 77/274 (28%), Positives = 130/274 (47%), Gaps = 18/274 (6%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 Y +G LG G FG V G VA+K + + +I + ++ E+ LK Sbjct: 14 GHYILGDTLGVGTFGKVKVGKHELTGHAVAVKILNRQKIRSLDVV---GKIRREIQNLKL 70 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 +I+L P +++E +LFD+I + G L E+ +R F Q+L V Sbjct: 71 FRH--PHIIKLYQVISTPSDIFMVMEYVSG-GELFDYICKNGRLDEKESRRLFQQILSGV 127 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPEWIR 214 +CH V+HRD+K EN+L+D + K+ DFG ++ D G+ Y+ PE I Sbjct: 128 DYCHRHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 186 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIR 268 Y G +WS G++LY ++CG +PF+ D ++I G + Q ++ L++ Sbjct: 187 GRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLK 246 Query: 269 WCLALRPSDRPTFEEIQNHPWMQD----VLLPQE 298 L + P R + ++I+ H W + L P++ Sbjct: 247 HMLQVDPMKRASIKDIREHEWFKQDLPKYLFPED 280 >3MA6-A nrPDB Length = 298 Score = 269 bits (689), Expect = 8e-73, Method: Composition-based stats. Identities = 73/291 (25%), Positives = 123/291 (42%), Gaps = 21/291 (7%) Query: 20 LHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGE 79 + +Y+ +LG G FG V A+K + K ++ + Sbjct: 16 FQGPGMFVQHSTAIFSDRYKGQRVLGKGSFGEVILCKDKITGQECAVKVISKRQV---KQ 72 Query: 80 LPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGAL 139 + + EV LLK++ +++L ++FE F L+ E +LFD I R Sbjct: 73 KTDKESLLREVQLLKQLDH--PNIMKLYEFFEDKGYFYLVGEVYTG-GELFDEIISRKRF 129 Query: 140 QEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILID--LNRGELKLIDFGSGALLK-DT 196 E A QVL + + H ++HRD+K EN+L++ +++IDFG + Sbjct: 130 SEVDAARIIRQVLSGITYMHKNKIVHRDLKPENLLLESKSKDANIRIIDFGLSTHFEASK 189 Query: 197 VYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH------DEEIIR 250 D GT Y PE + + VWS G++LY ++ G PF +++ + Sbjct: 190 KMKDKIGTAYYIAPEVLHGT--YDEKCDVWSTGVILYILLSGCPPFNGANEYDILKKVEK 247 Query: 251 GQVFFR----QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQ 297 G+ F ++VS + LIR L PS R + + +H W+Q Q Sbjct: 248 GKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISARDALDHEWIQTYTKEQ 298 >5YKS-A nrPDB Length = 377 Score = 269 bits (689), Expect = 1e-72, Method: Composition-based stats. Identities = 85/266 (31%), Positives = 129/266 (48%), Gaps = 15/266 (5%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 Y + LG G F V V VA+K ++K ++ + EV +K V Sbjct: 37 YDLDKTLGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDTLAT----GHLFQEVRCMKLVQ 92 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI-TERGALQEELARSFFWQVLEAVR 156 ++RL + + LILE + D+FD+I L E+LA+ +F Q++ A+ Sbjct: 93 H--PNIVRLYEVIDTQTKLYLILELGDG-GDMFDYIMKHEEGLNEDLAKKYFAQIVHAIS 149 Query: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSG-ALLKDTVYTDFDGTRVYSPPEWIRY 215 +CH V+HRD+K EN++ +G +KL DFG T G+ YS PE + Sbjct: 150 YCHKLHVVHRDLKPENVVFFEKQGLVKLTDFGFSNKFQPGKKLTTSCGSLAYSAPEILLG 209 Query: 216 HRYHGRSAAVWSLGILLYDMVCGDIPFE--HDEE----IIRGQVFFRQRVSSECQHLIRW 269 Y + +WSLG++L+ +VCG PF+ +D E I+ + VS EC+ LI Sbjct: 210 DEYDAPAVDIWSLGVILFMLVCGQPPFQEANDSETLTMIMDCKYTVPSHVSKECKDLITR 269 Query: 270 CLALRPSDRPTFEEIQNHPWMQDVLL 295 L P R + EEI+NHPW+Q V Sbjct: 270 MLQRDPKRRASLEEIENHPWLQGVDP 295 >3NCG-A nrPDB Length = 486 Score = 269 bits (688), Expect = 1e-72, Method: Composition-based stats. Identities = 77/273 (28%), Positives = 121/273 (44%), Gaps = 22/273 (8%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 +Y + +LG G FG V A+K + K + + + + EV LL Sbjct: 20 FAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKN----KDTSTILREVELL 75 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 KK+ +++L + E SF ++ E +LFD I +R E A QV Sbjct: 76 KKLDH--PNIMKLFEILEDSSSFYIVGELYTG-GELFDEIIKRKRFSEHDAARIIKQVFS 132 Query: 154 AVRHCHNCGVLHRDIKDENILID--LNRGELKLIDFGSGALL-KDTVYTDFDGTRVYSPP 210 + + H ++HRD+K ENIL++ ++K+IDFG ++T D GT Y P Sbjct: 133 GITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAP 192 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFR----QRVS 260 E +R + VWS G++LY ++ G PF E + G+ F + +S Sbjct: 193 EVLRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTIS 250 Query: 261 SECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 + + LIR L PS R T + HPW+Q Sbjct: 251 DDAKDLIRKMLTFHPSLRITATQCLEHPWIQKY 283 >5EZV-A nrPDB Length = 560 Score = 268 bits (686), Expect = 2e-72, Method: Composition-based stats. Identities = 78/274 (28%), Positives = 131/274 (47%), Gaps = 18/274 (6%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 Y +G LG G FG V G VA+K + + +I + ++ E+ LK Sbjct: 28 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVV---GKIKREIQNLKL 84 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 +I+L P F +++E +LFD+I + G ++E AR F Q+L AV Sbjct: 85 FRH--PHIIKLYQVISTPTDFFMVMEYVSG-GELFDYICKHGRVEEMEARRLFQQILSAV 141 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPEWIR 214 +CH V+HRD+K EN+L+D + K+ DFG ++ D G+ Y+ PE I Sbjct: 142 DYCHRHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVIS 200 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIR 268 Y G +WS G++LY ++CG +PF+ + ++I G + + ++ L+ Sbjct: 201 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLM 260 Query: 269 WCLALRPSDRPTFEEIQNHPWMQD----VLLPQE 298 L + P R T ++I+ H W + L P++ Sbjct: 261 HMLQVDPLKRATIKDIREHEWFKQDLPSYLFPED 294 >4WB7-A nrPDB Length = 405 Score = 267 bits (683), Expect = 4e-72, Method: Composition-based stats. Identities = 74/298 (24%), Positives = 136/298 (45%), Gaps = 21/298 (7%) Query: 7 NSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAI 66 + A D +P + L Q++ LG+G FG V A+ Sbjct: 68 EEVKEFLAKAKEDFLKKWESPAQNTAHL-DQFERIKTLGTGSFGRVMLVKHKETGNHYAM 126 Query: 67 KHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPV 126 K ++K ++ ++ + E +L+ V+ F +++L F+ + +++E P Sbjct: 127 KILDKQKVVKLKQIEH---TLNEKRILQAVN--FPFLVKLEFSFKDNSNLYMVMEYV-PG 180 Query: 127 QDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLID 186 ++F + G E AR + Q++ + H+ +++RD+K EN+LID +G +++ D Sbjct: 181 GEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLID-QQGYIQVTD 239 Query: 187 FGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE 246 FG +K +T GT Y PE I Y+ ++ W+LG+L+Y+M G PF D+ Sbjct: 240 FGFAKRVKGRTWT-LCGTPEYLAPEIILSKGYN-KAVDWWALGVLIYEMAAGYPPFFADQ 297 Query: 247 ------EIIRGQVFFRQRVSSECQHLIRWCLALRPSDR-----PTFEEIQNHPWMQDV 293 +I+ G+V F SS+ + L+R L + + R +I+NH W Sbjct: 298 PIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATT 355 >3DFA-A nrPDB Length = 286 Score = 267 bits (682), Expect = 6e-72, Method: Composition-based stats. Identities = 77/273 (28%), Positives = 121/273 (44%), Gaps = 22/273 (8%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 +Y + +LG G FG V A+K + K + + + + EV LL Sbjct: 20 FAERYNIVCMLGKGSFGEVLKCKDRITQQEYAVKVINKASAKN----KDTSTILREVELL 75 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 KK+ +++L + E SF ++ E +LFD I +R E A QV Sbjct: 76 KKLDH--PNIMKLFEILEDSSSFYIVGELYTG-GELFDEIIKRKRFSEHDAARIIKQVFS 132 Query: 154 AVRHCHNCGVLHRDIKDENILID--LNRGELKLIDFGSGALL-KDTVYTDFDGTRVYSPP 210 + + H ++HRD+K ENIL++ ++K+IDFG ++T D GT Y P Sbjct: 133 GITYMHKHNIVHRDLKPENILLESKEKDCDIKIIDFGLSTCFQQNTKMKDRIGTAYYIAP 192 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFR----QRVS 260 E +R + VWS G++LY ++ G PF E + G+ F + +S Sbjct: 193 EVLRGT--YDEKCDVWSAGVILYILLSGTPPFYGKNEYDILKRVETGKYAFDLPQWRTIS 250 Query: 261 SECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 + + LIR L PS R T + HPW+Q Sbjct: 251 DDAKDLIRKMLTFHPSLRITATQCLEHPWIQKY 283 >4CQG-A nrPDB Length = 331 Score = 265 bits (679), Expect = 1e-71, Method: Composition-based stats. Identities = 96/280 (34%), Positives = 143/280 (51%), Gaps = 19/280 (6%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 K+ + L Y++ +G+GGF V V VAIK ++K+ + + RV Sbjct: 2 KDYDELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGS-----DLPRVKT 56 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 148 E+ LK + + +L E + ++LE P +LFD+I + L EE R F Sbjct: 57 EIDALKSLRHQH--ICQLYHVLETKNKIFMVLEYC-PGGELFDYIISQDRLSEEETRVVF 113 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL---KDTVYTDFDGTR 205 Q+L AV + H+ G HRD+K EN+L D N +LKLIDFG A KD + G+ Sbjct: 114 RQILSAVAYVHSQGYAHRDLKPENLLFDEN-HKLKLIDFGLCAKPKGNKDYHLQECCGSL 172 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRV 259 Y+ PE I+ Y G A VWS+GILLY ++CG +PF+ D ++I+RG+ + + Sbjct: 173 AYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYEVPKWL 232 Query: 260 SSECQHLIRWCLALRPSDRPTFEEIQNHPW-MQDVLLPQE 298 S L++ L + P R + + NHPW MQD P E Sbjct: 233 SPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYSCPVE 272 >4D2V-A nrPDB Length = 356 Score = 265 bits (678), Expect = 1e-71, Method: Composition-based stats. Identities = 91/280 (32%), Positives = 140/280 (50%), Gaps = 19/280 (6%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 K+ + L Y++ +G+GGF V + VAIK ++K+ + + R+ Sbjct: 22 KDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGS-----DLPRIKT 76 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 148 E+ LK + + +L E + ++LE P +LFD+I + L EE R F Sbjct: 77 EIEALKNLRHQH--ICQLYHVLETANKIFMVLEYC-PGGELFDYIISQDRLSEEETRVVF 133 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL---KDTVYTDFDGTR 205 Q++ AV + H+ G HRD+K EN+L D +LKLIDFG A KD G Sbjct: 134 RQIVSAVAYVHSQGYAHRDLKPENLLFD-EYHKLKLIDFGLCAKPKGNKDYHLQACCGAL 192 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EIIRGQVFFRQRV 259 Y+ PE I+ Y G A VWS+GILLY ++CG +PF+ D +I+RG+ + + Sbjct: 193 AYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWL 252 Query: 260 SSECQHLIRWCLALRPSDRPTFEEIQNHPWM-QDVLLPQE 298 S L++ L + P R + + + NHPW+ QD P E Sbjct: 253 SPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVE 292 >4YZB-A nrPDB Length = 491 Score = 265 bits (678), Expect = 2e-71, Method: Composition-based stats. Identities = 68/282 (24%), Positives = 119/282 (42%), Gaps = 21/282 (7%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 +Y+ +LG G FG V A+K + K ++ + + Sbjct: 28 FSDRYKGQRVLGKGSFGEVILCKDKVTGQEYAVKVISKRQVKQKTDKELLLKEVE----- 82 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 +++L ++FE F L+ E +LFD I R E A QVL Sbjct: 83 LLKKLDHPNIMKLYEFFEDKGYFYLVTEVYTG-GELFDEIISRKRFSEVDAARIIRQVLS 141 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNR--GELKLIDFGSGALLKDT-VYTDFDGTRVYSPP 210 + + H ++HRD+K EN+L++ R +++IDFG + T D GT Y P Sbjct: 142 GITYMHKNKIVHRDLKPENLLLENKRKDANIRIIDFGLSTHFESTKKMKDKIGTAYYIAP 201 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH------DEEIIRGQVFFR----QRVS 260 E + + VWS G++LY ++ G PF +++ +G+ F ++VS Sbjct: 202 EVLHGT--YDEKCDVWSTGVILYILLSGCPPFNGANEFDILKKVEKGKFTFDLPQWKKVS 259 Query: 261 SECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEI 302 + LIR LA P+ R + + H W++ ++ ++ Sbjct: 260 EPAKDLIRKMLAYVPTMRISARDALEHEWLKTTDAATDSIDV 301 >5FG8-A nrPDB Length = 285 Score = 265 bits (677), Expect = 2e-71, Method: Composition-based stats. Identities = 72/271 (26%), Positives = 122/271 (45%), Gaps = 22/271 (8%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 Y + LG G F V ++ S A K + +++ + ++ E + Sbjct: 12 FSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTAR----DFQKLEREARIC 67 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 +K+ ++RL D + + L+ + +LF+ I R E A Q+LE Sbjct: 68 RKLHH--PNIVRLHDSIQEENYHYLVFDLVTG-GELFEDIVAREFYSEADASHCIQQILE 124 Query: 154 AVRHCHNCGVLHRDIKDENILI--DLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSP 209 +V HCH GV+HRD+K EN+L+ +KL DFG ++ + F GT Y Sbjct: 125 SVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLS 184 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EIIRGQVFFRQR----V 259 PE ++ Y G+S +W+ G++LY ++ G PF ++ +I G + V Sbjct: 185 PEVLKKEPY-GKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTV 243 Query: 260 SSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 + E ++LI L + P+ R T E HPW+ Sbjct: 244 TPEAKNLINQMLTVNPNKRITAAEALKHPWI 274 >2JC6-A nrPDB Length = 334 Score = 264 bits (675), Expect = 4e-71, Method: Composition-based stats. Identities = 72/275 (26%), Positives = 129/275 (46%), Gaps = 22/275 (8%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 K+ E ++ ++ LG+G F V + A+K + K + + + Sbjct: 15 KQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKG-----KESSIEN 69 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 148 E+ +L+K+ ++ L D +E P+ L+++ +LFD I E+G E+ A + Sbjct: 70 EIAVLRKIKH--ENIVALEDIYESPNHLYLVMQLVSG-GELFDRIVEKGFYTEKDASTLI 126 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILI--DLNRGELKLIDFGSGALL-KDTVYTDFDGTR 205 QVL+AV + H G++HRD+K EN+L ++ + DFG + K V + GT Sbjct: 127 RQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKGDVMSTACGTP 186 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFR--- 256 Y PE + Y ++ WS+G++ Y ++CG PF + E+I++ + F Sbjct: 187 GYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPY 245 Query: 257 -QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 +S + IR + P+ R T E+ HPW+ Sbjct: 246 WDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI 280 >4FG9-A nrPDB Length = 320 Score = 263 bits (672), Expect = 8e-71, Method: Composition-based stats. Identities = 76/284 (26%), Positives = 128/284 (45%), Gaps = 22/284 (7%) Query: 20 LHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGE 79 L A + K+ E + Y +LG+G F V VAIK + K+ + Sbjct: 2 LGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEG--- 58 Query: 80 LPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGAL 139 + E+ +L K+ ++ L D +E LI++ +LFD I E+G Sbjct: 59 --KEGSMENEIAVLHKIKH--PNIVALDDIYESGGHLYLIMQLVSG-GELFDRIVEKGFY 113 Query: 140 QEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDL--NRGELKLIDFGSGALLK-DT 196 E A +QVL+AV++ H+ G++HRD+K EN+L ++ + DFG + + Sbjct: 114 TERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGS 173 Query: 197 VYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIR 250 V + GT Y PE + Y ++ WS+G++ Y ++CG PF + E+I++ Sbjct: 174 VLSTACGTPGYVAPEVLAQKPY-SKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILK 232 Query: 251 GQVFFR----QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 + F +S + IR + P R T E+ HPW+ Sbjct: 233 AEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWI 276 >5IG1-A nrPDB Length = 344 Score = 262 bits (671), Expect = 1e-70, Method: Composition-based stats. Identities = 69/267 (25%), Positives = 120/267 (44%), Gaps = 21/267 (7%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 ++G G F +V+ + A+K + + ++ E+ + + Sbjct: 24 VIGKGAFSTVHRCVNKRTGEVCAVKVIALKSLRS----SEINKIKREIGICSSLQHEH-- 77 Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCG 162 ++ + F F L+ E +LFD I R E+ A + Q+L A++HCH+ Sbjct: 78 IVSMRRAFRDESHFYLVFEYVSG-GELFDEIVTRKFYNEKDASACMHQILSALQHCHSKN 136 Query: 163 VLHRDIKDENILIDLNR--GELKLIDFGSGALLK-DTVYTDFDGTRVYSPPEWIRYHRYH 219 ++HRD+K EN+L+ +K+ DFG +++ Y F GT Y PE IR Y Sbjct: 137 IIHRDLKPENLLLASKDPNAPVKITDFGLAVIMEQGPTYFGFAGTPGYLSPEVIRRVPYD 196 Query: 220 GRSAAVWSLGILLYDMVCGDIPFEHDE------EIIRGQVFFRQR----VSSECQHLIRW 269 + VW+ G++LY ++ G PF ++ +I Q F V++ + LI+ Sbjct: 197 T-AVDVWACGVILYILLVGYPPFWEEDHQKLYAQIKNCQYDFPSPEWDSVTTAAKELIKA 255 Query: 270 CLALRPSDRPTFEEIQNHPWMQDVLLP 296 L P RPT +E+ HPW+ +P Sbjct: 256 MLEPNPKRRPTVQELLQHPWIARRDVP 282 >2YZA-A nrPDB Length = 276 Score = 262 bits (670), Expect = 1e-70, Method: Composition-based stats. Identities = 78/267 (29%), Positives = 129/267 (48%), Gaps = 14/267 (5%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 Y +G LG G FG V G VA+K + + +I + ++ E+ LK Sbjct: 11 GHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVV---GKIKREIQNLKL 67 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 +I+L P F +++E +LFD+I + G ++E AR F Q+L AV Sbjct: 68 FRH--PHIIKLYQVISTPTDFFMVMEYVSG-GELFDYICKHGRVEEMEARRLFQQILSAV 124 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPEWIR 214 +CH V+HRD+K EN+L+D + K+ DFG ++ D D G+ Y+ PE I Sbjct: 125 DYCHRHMVVHRDLKPENVLLDAHMN-AKIADFGLSNMMSDGEFLRDSCGSPNYAAPEVIS 183 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIR 268 Y G +WS G++LY ++CG +PF+ + ++I G + + ++ L+ Sbjct: 184 GRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRSVATLLM 243 Query: 269 WCLALRPSDRPTFEEIQNHPWMQDVLL 295 L + P R T ++I+ H W + L Sbjct: 244 HMLQVDPLKRATIKDIREHEWFKQDLP 270 >2HAK-A nrPDB Length = 328 Score = 261 bits (668), Expect = 2e-70, Method: Composition-based stats. Identities = 77/297 (25%), Positives = 145/297 (48%), Gaps = 19/297 (6%) Query: 22 ATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELP 81 + +++P Y++ +G G F V V VA+K ++K ++ Sbjct: 1 GNSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQL----NPT 56 Query: 82 NGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQE 141 + ++ EV ++K ++ +++L + E + L++E ++FD++ G ++E Sbjct: 57 SLQKLFREVRIMKILNH--PNIVKLFEVIETEKTLYLVMEYASG-GEVFDYLVAHGRMKE 113 Query: 142 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTD 200 + AR+ F Q++ AV++CH ++HRD+K EN+L+D + +K+ DFG Sbjct: 114 KEARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMN-IKIADFGFSNEFTVGNKLDT 172 Query: 201 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH------DEEIIRGQVF 254 F G+ Y+ PE + +Y G VWSLG++LY +V G +PF+ E ++RG+ Sbjct: 173 FCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYR 232 Query: 255 FRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGP 311 +S++C++L++ L L P R + E+I WM +E P P Sbjct: 233 IPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEEL----KPYTEPDP 285 >6C9D-A nrPDB Length = 459 Score = 261 bits (668), Expect = 2e-70, Method: Composition-based stats. Identities = 77/296 (26%), Positives = 146/296 (49%), Gaps = 19/296 (6%) Query: 23 TKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPN 82 + +++P Y++ +G G F V V VA+K ++K ++ + Sbjct: 8 NSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQL----NPTS 63 Query: 83 GTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEE 142 ++ EV ++K ++ +++L + E + L++E ++FD++ G ++E+ Sbjct: 64 LQKLFREVRIMKILNH--PNIVKLFEVIETEKTLYLVMEYASG-GEVFDYLVAHGRMKEK 120 Query: 143 LARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDF 201 AR+ F Q++ AV++CH ++HRD+K EN+L+D + +K+ DFG +F Sbjct: 121 EARAKFRQIVSAVQYCHQKYIVHRDLKAENLLLDGDMN-IKIADFGFSNEFTVGNKLDEF 179 Query: 202 DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH------DEEIIRGQVFF 255 G+ Y+ PE + +Y G VWSLG++LY +V G +PF+ E ++RG+ Sbjct: 180 CGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRI 239 Query: 256 RQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGP 311 +S++C++L++ L L P R + E+I WM +E P P Sbjct: 240 PFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEEL----KPYTEPDP 291 >5WAX-A nrPDB Length = 310 Score = 261 bits (667), Expect = 3e-70, Method: Composition-based stats. Identities = 84/280 (30%), Positives = 126/280 (45%), Gaps = 25/280 (8%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +Y++ +GSG FG +D VA+K++E+ D V E++ + Sbjct: 11 DRYELVRDIGSGNFGVARLMRNRADGQLVAVKYIERGEKID-------ENVQREIINHRS 63 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 + +IR + P +++E +LF+ I G E+ AR FF Q++ V Sbjct: 64 LRH--PNIIRFKEVILTPTHLAIVMEYASG-GELFERICNAGRFSEDEARFFFQQLISGV 120 Query: 156 RHCHNCGVLHRDIKDENILIDLNRG-ELKLIDFGSGAL-LKDTVYTDFDGTRVYSPPEWI 213 +CH+ V HRD+K EN L+D + LK+ DFG + + GT Y PE + Sbjct: 121 SYCHSMQVCHRDLKLENTLLDGSTAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEVL 180 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE----------IIRGQVFFRQ--RVSS 261 Y G+ A VWS G+ LY M+ G PFE +E I+ Q +S Sbjct: 181 LKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPDEPKNFRKTIQRILGVQYSIPDYVHISP 240 Query: 262 ECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAE 301 ECQ LI P+ R T EI+NHPW LP + + Sbjct: 241 ECQDLISRIFVANPATRITIPEIRNHPWFLK-NLPADLMD 279 >2BDW-A nrPDB Length = 362 Score = 260 bits (665), Expect = 5e-70, Method: Composition-based stats. Identities = 67/271 (24%), Positives = 119/271 (43%), Gaps = 21/271 (7%) Query: 33 PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVL 92 Y V LG G F V + + L A K + ++S + ++ E + Sbjct: 26 KFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSAR----DFQKLEREARI 81 Query: 93 LKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 +K+ ++RL D + L+ + +LF+ I R E A Q+L Sbjct: 82 CRKLQH--PNIVRLHDSIQEESFHYLVFDLVTG-GELFEDIVAREFYSEADASHCIQQIL 138 Query: 153 EAVRHCHNCGVLHRDIKDENILI--DLNRGELKLIDFGSGALLKDTV-YTDFDGTRVYSP 209 E++ +CH+ G++HR++K EN+L+ +KL DFG + D+ + F GT Y Sbjct: 139 ESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLS 198 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EIIRGQVFFRQR----V 259 PE ++ Y + +W+ G++LY ++ G PF ++ +I G + V Sbjct: 199 PEVLKKDPY-SKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTV 257 Query: 260 SSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 + E + LI L + P R T ++ PW+ Sbjct: 258 TPEAKSLIDSMLTVNPKKRITADQALKVPWI 288 >3Q5I-A nrPDB Length = 504 Score = 260 bits (665), Expect = 5e-70, Method: Composition-based stats. Identities = 82/298 (27%), Positives = 134/298 (44%), Gaps = 29/298 (9%) Query: 20 LHATKLAPG----KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRIS 75 + PG K++ + Y LGSG +G V + + AIK ++K + Sbjct: 16 FQGIAINPGMYVRKKEGKIGESYFKVRKLGSGAYGEVLLCKEKNGHSEKAIKVIKKSQFD 75 Query: 76 D-------WGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQD 128 + E+ LLK + +I+L D FE F L+ E E + Sbjct: 76 KGRYSDDNKNIEKFHEEIYNEISLLKSLDH--PNIIKLFDVFEDKKYFYLVTEFYEG-GE 132 Query: 129 LFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG--ELKLID 186 LF+ I R E A + Q+L + + H ++HRDIK ENIL++ +K++D Sbjct: 133 LFEQIINRHKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKNSLLNIKIVD 192 Query: 187 FGSGALL-KDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--E 243 FG + KD D GT Y PE + + + VWS G+++Y ++CG PF + Sbjct: 193 FGLSSFFSKDYKLRDRLGTAYYIAPEVL--KKKYNEKCDVWSCGVIMYILLCGYPPFGGQ 250 Query: 244 HDEEII----RGQVFFR----QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 +D++II +G+ +F + +S E + LI+ L + R T EE N W++ Sbjct: 251 NDQDIIKKVEKGKYYFDFNDWKNISDEAKELIKLMLTYDYNKRCTAEEALNSRWIKKY 308 >2VN9-A nrPDB Length = 301 Score = 259 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 75/288 (26%), Positives = 126/288 (43%), Gaps = 28/288 (9%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 + +YQ+ LG G F V +++ A K + ++S + ++ E + Sbjct: 2 MTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSAR----DHQKLEREARIC 57 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 + + ++RL D L+ + +LF+ I R E A Q+LE Sbjct: 58 RLLKH--PNIVRLHDSISEEGFHYLVFDLVTG-GELFEDIVAREYYSEADASHCIQQILE 114 Query: 154 AVRHCHNCGVLHRDIKDENILI--DLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSP 209 +V HCH G++HRD+K EN+L+ +KL DFG ++ + F GT Y Sbjct: 115 SVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 174 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQR----V 259 PE +R Y G+ +W+ G++LY ++ G PF + ++I G F V Sbjct: 175 PEVLRKDPY-GKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTV 233 Query: 260 SSECQHLIRWCLALRPSDRPTFEEIQNHPWM------QDVLLPQETAE 301 + E + LI L + P+ R T E HPW+ ++ QET + Sbjct: 234 TPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVD 281 >2VZ6-A nrPDB Length = 313 Score = 259 bits (661), Expect = 2e-69, Method: Composition-based stats. Identities = 80/284 (28%), Positives = 125/284 (44%), Gaps = 22/284 (7%) Query: 22 ATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELP 81 ++ + G E +S YQ+ LG G F V ++V A K + ++S Sbjct: 8 SSGVDLGTENLYFQSMYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSAR---- 63 Query: 82 NGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQE 141 + ++ E + + + ++RL D LI + +LF+ I R E Sbjct: 64 DHQKLEREARICRLLKH--PNIVRLHDSISEEGHHYLIFDLVTG-GELFEDIVAREYYSE 120 Query: 142 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDL--NRGELKLIDFGSGALLKDTV-- 197 A Q+LEAV HCH GV+HRD+K EN+L+ +KL DFG ++ Sbjct: 121 ADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQA 180 Query: 198 YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRG 251 + F GT Y PE +R Y G+ +W+ G++LY ++ G PF + ++I G Sbjct: 181 WFGFAGTPGYLSPEVLRKDPY-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAG 239 Query: 252 QVFFRQR----VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 F V+ E + LI L + PS R T E HPW+ Sbjct: 240 AYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWIS 283 >4RGJ-A nrPDB Length = 520 Score = 258 bits (660), Expect = 2e-69, Method: Composition-based stats. Identities = 77/308 (25%), Positives = 132/308 (42%), Gaps = 27/308 (8%) Query: 18 NDLHATKLAPG----KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDR 73 N + +KL PG QY+ +LG G FG V AIK + K Sbjct: 38 NSFNNSKLRPGMFIQNSNVVFNEQYKGIKILGKGSFGEVILSRDKHTGHEYAIKVISKKH 97 Query: 74 ISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI 133 + + + EV LLK + +++L ++FE + + L+ + +LFD I Sbjct: 98 VKRK---TDKESLLREVELLKMLDHI--NIMKLYEFFEDNNYYYLVSDVYTG-GELFDEI 151 Query: 134 TERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE---LKLIDFGSG 190 R E A Q+L + + H V+HRD+K ENIL++ E +K+IDFG Sbjct: 152 ISRKRFYEIDAARIIKQILSGITYMHKNNVVHRDLKPENILLETKNKEDMIIKIIDFGLS 211 Query: 191 ALLK-DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE-- 247 + D GT Y P+ + + +WS G++LY ++ G PF E Sbjct: 212 THFEYSKKMKDKIGTAYYIAPDVLHGT--YDEKCDIWSCGVILYILLSGCPPFNGSNEYD 269 Query: 248 ----IIRGQVFFR----QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQET 299 + G+ F +++S + + LI+ L + R + + H W++ ++ ++ Sbjct: 270 ILKKVEAGKYTFDLPQFKKISDKAKDLIKKMLMYTSAVRISARDALEHEWIK-MMTSKDN 328 Query: 300 AEIHLHSL 307 I + SL Sbjct: 329 LNIDIPSL 336 >3KK8-A nrPDB Length = 284 Score = 258 bits (659), Expect = 3e-69, Method: Composition-based stats. Identities = 67/271 (24%), Positives = 119/271 (43%), Gaps = 21/271 (7%) Query: 33 PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVL 92 Y V LG G F V + + L A K + ++S + ++ E + Sbjct: 3 KFSDNYDVKEELGKGAFSVVRRCVHKTTGLEFAAKIINTKKLSAR----DFQKLEREARI 58 Query: 93 LKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 +K+ ++RL D + L+ + +LF+ I R E A Q+L Sbjct: 59 CRKLQH--PNIVRLHDSIQEESFHYLVFDLVTG-GELFEDIVAREFYSEADASHCIQQIL 115 Query: 153 EAVRHCHNCGVLHRDIKDENILI--DLNRGELKLIDFGSGALLKDTV-YTDFDGTRVYSP 209 E++ +CH+ G++HR++K EN+L+ +KL DFG + D+ + F GT Y Sbjct: 116 ESIAYCHSNGIVHRNLKPENLLLASKAKGAAVKLADFGLAIEVNDSEAWHGFAGTPGYLS 175 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EIIRGQVFFRQR----V 259 PE ++ Y + +W+ G++LY ++ G PF ++ +I G + V Sbjct: 176 PEVLKKDPY-SKPVDIWACGVILYILLVGYPPFWDEDQHRLYAQIKAGAYDYPSPEWDTV 234 Query: 260 SSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 + E + LI L + P R T ++ PW+ Sbjct: 235 TPEAKSLIDSMLTVNPKKRITADQALKVPWI 265 >3D2K-A nrPDB Length = 272 Score = 258 bits (659), Expect = 3e-69, Method: Composition-based stats. Identities = 79/272 (29%), Positives = 125/272 (45%), Gaps = 14/272 (5%) Query: 26 APGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTR 85 G +++ + +G LG G FG+VY +A+K + K ++ G + + R Sbjct: 2 PLGSKRQWTLEDFDIGRPLGKGKFGNVYLARERQSKFILALKVLFKTQLEKAG-VEHQLR 60 Query: 86 VPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELAR 145 EV + + ++RL +F LILE P+ ++ + + E+ Sbjct: 61 --REVEIQSHLRH--PNILRLYGYFHDATRVYLILEYA-PLGTVYRELQKLSRFDEQRTA 115 Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTR 205 ++ ++ A+ +CH+ V+HRDIK EN+L+ N GELK+ DFG + T GT Sbjct: 116 TYITELANALSYCHSKRVIHRDIKPENLLLGSN-GELKIADFGWSVHAPSSRRTTLCGTL 174 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EIIRGQVFFRQRV 259 Y PPE I R H +WSLG+L Y+ + G PFE I R + F V Sbjct: 175 DYLPPEMIEG-RMHDEKVDLWSLGVLCYEFLVGMPPFEAHTYQETYRRISRVEFTFPDFV 233 Query: 260 SSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 + + LI L S R T E+ HPW++ Sbjct: 234 TEGARDLISRLLKHNASQRLTLAEVLEHPWIK 265 >4UZD-A nrPDB Length = 287 Score = 257 bits (658), Expect = 3e-69, Method: Composition-based stats. Identities = 78/267 (29%), Positives = 126/267 (47%), Gaps = 14/267 (5%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 89 +++ +++G LG G FG+VY +A+K + K ++ G + + R E Sbjct: 2 KRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAG-VEHQLR--RE 58 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 V + + ++RL +F LILE P+ ++ + + E+ ++ Sbjct: 59 VEIQSHLRH--PNILRLYGYFHDATRVYLILEYA-PLGTVYRELQKLSKFDEQRTATYIT 115 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSP 209 ++ A+ +CH+ V+HRDIK EN+L+ GELK+ DFG + T GT Y P Sbjct: 116 ELANALSYCHSKRVIHRDIKPENLLLGS-AGELKIADFGWSVHAPSSRRTTLCGTLDYLP 174 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSEC 263 PE I R H +WSLG+L Y+ + G PFE + + I R + F V+ Sbjct: 175 PEMIEG-RMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGA 233 Query: 264 QHLIRWCLALRPSDRPTFEEIQNHPWM 290 + LI L PS RP E+ HPW+ Sbjct: 234 RDLISRLLKHNPSQRPMLREVLEHPWI 260 >5U6Y-A nrPDB Length = 461 Score = 256 bits (654), Expect = 1e-68, Method: Composition-based stats. Identities = 77/268 (28%), Positives = 118/268 (44%), Gaps = 22/268 (8%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 YQ+ LG G F V ++V A K + ++S + ++ E + + + Sbjct: 2 YQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSAR----DHQKLEREARICRLLK 57 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 ++RL D LI + +LF+ I R E A Q+LEAV H Sbjct: 58 H--PNIVRLHDSISEEGHHYLIFDLVTG-GELFEDIVAREYYSEADASHCIQQILEAVLH 114 Query: 158 CHNCGVLHRDIKDENILIDL--NRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEWI 213 CH GV+HRD+K EN+L+ +KL DFG ++ + F GT Y PE + Sbjct: 115 CHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVL 174 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQR----VSSEC 263 R Y G+ +W+ G++LY ++ G PF + ++I G F V+ E Sbjct: 175 RKDPY-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEA 233 Query: 264 QHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 + LI L + PS R T E HPW+ Sbjct: 234 KDLINKMLTINPSKRITAAEALKHPWIS 261 >3ZUT-A nrPDB Length = 362 Score = 255 bits (653), Expect = 1e-68, Method: Composition-based stats. Identities = 79/270 (29%), Positives = 119/270 (44%), Gaps = 24/270 (8%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 +Y++ +GSG FG N VA+K++E+ D V E++ + Sbjct: 18 SDRYELVKDIGSGNFGVARLMRDKQSNELVAVKYIERGEKID-------ENVKREIINHR 70 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 + ++R + P +++E +LF+ I G E+ AR FF Q++ Sbjct: 71 SLRH--PNIVRFKEVILTPTHLAIVMEYASG-GELFERICNAGRFSEDEARFFFQQLISG 127 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRG-ELKLIDFGSGAL-LKDTVYTDFDGTRVYSPPEW 212 V +CH V HRD+K EN L+D + LK+ FG + + GT Y PE Sbjct: 128 VSYCHAMQVCHRDLKLENTLLDGSPAPRLKICAFGYSKSSVLHSQPKSTVGTPAYIAPEV 187 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE----------IIRGQVFFRQ--RVS 260 + Y G+ A VWS G+ LY M+ G PFE EE I+ Q +S Sbjct: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 Query: 261 SECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 EC+HLI P+ R + EI+NH W Sbjct: 248 PECRHLISRIFVADPAKRISIPEIRNHEWF 277 >2JAM-A nrPDB Length = 304 Score = 255 bits (653), Expect = 1e-68, Method: Composition-based stats. Identities = 73/265 (27%), Positives = 123/265 (46%), Gaps = 22/265 (8%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 + +LGSG F V+ + A+K ++K L N E+ +LKK+ Sbjct: 11 FIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAFRDSSLEN------EIAVLKKIK 64 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 ++ L D +E + L+++ +LFD I ERG E+ A QVL AV++ Sbjct: 65 H--ENIVTLEDIYESTTHYYLVMQLVSG-GELFDRILERGVYTEKDASLVIQQVLSAVKY 121 Query: 158 CHNCGVLHRDIKDENILI--DLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRY 215 H G++HRD+K EN+L ++ + DFG + ++ + + GT Y PE + Sbjct: 122 LHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTACGTPGYVAPEVLAQ 181 Query: 216 HRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFR----QRVSSECQH 265 Y ++ WS+G++ Y ++CG PF + E+I G F +S + Sbjct: 182 KPY-SKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKD 240 Query: 266 LIRWCLALRPSDRPTFEEIQNHPWM 290 I L P++R T E+ +HPW+ Sbjct: 241 FICHLLEKDPNERYTCEKALSHPWI 265 >2JDO-A nrPDB Length = 342 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 70/287 (24%), Positives = 126/287 (43%), Gaps = 21/287 (7%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 + + LLG G FG V + A+K + K+ I E+ + E +L+ Sbjct: 10 NDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTV---TESRVLQN 66 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 F + L F+ D ++E +LF ++ EE AR + +++ A+ Sbjct: 67 TRHPF--LTALKYAFQTHDRLCFVMEYANG-GELFFHLSRERVFTEERARFYGAEIVSAL 123 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA--LLKDTVYTDFDGTRVYSPPEWI 213 + H+ V++RDIK EN+++D + G +K+ DFG + F GT Y PE + Sbjct: 124 EYLHSRDVVYRDIKLENLMLDKD-GHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVL 182 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRVSSECQHLI 267 + Y GR+ W LG+++Y+M+CG +PF + + I+ ++ F + +S E + L+ Sbjct: 183 EDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLL 241 Query: 268 RWCLALRPSDRPT-----FEEIQNHPWMQDVLLPQETAEIHLHSLSP 309 L P R +E+ H + + + L P Sbjct: 242 AGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKP 288 >4YNZ-A nrPDB Length = 342 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 85/260 (32%), Positives = 140/260 (53%), Gaps = 15/260 (5%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 Y++ LG G G V GI VAIK V ++++S+ + +V E+ +LK + Sbjct: 12 YRLEKTLGKGQTGLVKLGIHCVTCQKVAIKIVNREKLSESVLM----KVEREIAILKLIE 67 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 V++L D +E L+LE +LFD++ ++G L + AR FF Q++ A+ Sbjct: 68 H--PHVLKLHDVYENKKYLYLVLEHVSG-GELFDYLVKKGRLTPKEARKFFRQIISALDF 124 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL-LKDTVYTDFDGTRVYSPPEWIRYH 216 CH+ + HRD+K EN+L+D R +++ DFG +L + D++ G+ Y+ PE IR Sbjct: 125 CHSHSICHRDLKPENLLLD-ERNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIRGE 183 Query: 217 RYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRWC 270 +Y GR A VWS G++L+ ++ G +PF+ D E++ RG + +CQ L+R Sbjct: 184 KYDGRKADVWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGM 243 Query: 271 LALRPSDRPTFEEIQNHPWM 290 + + + R T E IQ H W Sbjct: 244 IEVDAARRLTLEHIQKHIWY 263 >1FOT-A nrPDB Length = 318 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 72/284 (25%), Positives = 135/284 (47%), Gaps = 20/284 (7%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +Q+ LG+G FG V+ + A+K ++K+ + ++ + E ++L V Sbjct: 7 DFQILRTLGTGSFGRVHLIRSRHNGRYYAMKVLKKEIVVRLKQVEHTND---ERLMLSIV 63 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156 + F +IR+ F+ +I++ E +LF + + +A+ + +V A+ Sbjct: 64 THPF--IIRMWGTFQDAQQIFMIMDYIEG-GELFSLLRKSQRFPNPVAKFYAAEVCLALE 120 Query: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYH 216 + H+ +++RD+K ENIL+D N G +K+ DFG + D YT GT Y PE + Sbjct: 121 YLHSKDIIYRDLKPENILLDKN-GHIKITDFGFAKYVPDVTYT-LCGTPDYIAPEVVSTK 178 Query: 217 RYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRWC 270 Y+ +S WS GIL+Y+M+ G PF E+I+ ++ F + + + L+ Sbjct: 179 PYN-KSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRL 237 Query: 271 LALRPSDRP-----TFEEIQNHPWMQDVLLPQETAEIHLHSLSP 309 + S R E+++NHPW ++V+ + + P Sbjct: 238 ITRDLSQRLGNLQNGTEDVKNHPWFKEVVWEKLLSRNIETPYEP 281 >3UC3-A nrPDB Length = 361 Score = 255 bits (652), Expect = 2e-68, Method: Composition-based stats. Identities = 82/293 (27%), Positives = 123/293 (41%), Gaps = 24/293 (8%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 +Y +GSG FG VA+K++E+ D V E++ + Sbjct: 19 SDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAID-------ENVQREIINHR 71 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 + ++R + P +I+E +L++ I G E+ AR FF Q+L Sbjct: 72 SLRH--PNIVRFKEVILTPTHLAIIMEYASG-GELYERICNAGRFSEDEARFFFQQLLSG 128 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRG-ELKLIDFGSGAL-LKDTVYTDFDGTRVYSPPEW 212 V +CH+ + HRD+K EN L+D + LK+ DFG + + GT Y PE Sbjct: 129 VSYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSVLHSQPKSTVGTPAYIAPEV 188 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE----------IIRGQVFFRQ--RVS 260 + Y G+ A VWS G+ LY M+ G PFE EE I+ + R+S Sbjct: 189 LLRQEYDGKIADVWSCGVTLYVMLVGAYPFEDPEEPRDYRKTIQRILSVKYSIPDDIRIS 248 Query: 261 SECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK 313 EC HLI P+ R + EI+ H W L E + S P + Sbjct: 249 PECCHLISRIFVADPATRISIPEIKTHSWFLKNLPADLMNESNTGSQFQEPEQ 301 >2V7O-A nrPDB Length = 336 Score = 255 bits (651), Expect = 2e-68, Method: Composition-based stats. Identities = 73/288 (25%), Positives = 124/288 (43%), Gaps = 28/288 (9%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 YQ+ LG G F V ++ + A K + ++S + ++ E + Sbjct: 29 FTDDYQLFEELGKGAFSVVRRCVKKTPTQEYAAKIINTKKLSAR----DHQKLEREARIC 84 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 + + ++RL D L+ + +LF+ I R E A Q+LE Sbjct: 85 RLLKH--PNIVRLHDSISEEGFHYLVFDLVTG-GELFEDIVAREYYSEADASHCIHQILE 141 Query: 154 AVRHCHNCGVLHRDIKDENILIDL--NRGELKLIDFGSGALLKDTV--YTDFDGTRVYSP 209 +V H H ++HRD+K EN+L+ +KL DFG ++ + F GT Y Sbjct: 142 SVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLS 201 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQR----V 259 PE +R Y G+ +W+ G++LY ++ G PF + ++I G F V Sbjct: 202 PEVLRKDPY-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTV 260 Query: 260 SSECQHLIRWCLALRPSDRPTFEEIQNHPW------MQDVLLPQETAE 301 + E ++LI L + P+ R T ++ HPW + ++ QET E Sbjct: 261 TPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVE 308 >5KCV-A nrPDB Length = 460 Score = 254 bits (649), Expect = 4e-68, Method: Composition-based stats. Identities = 67/288 (23%), Positives = 129/288 (44%), Gaps = 22/288 (7%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 ++++ LLG G FG V + A+K ++K+ I E+ + E +L+ Sbjct: 162 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH---TLTENRVLQ- 217 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 +S + L F+ D ++E +LF ++ E+ AR + +++ A+ Sbjct: 218 -NSRHPFLTALKYSFQTHDRLCFVMEYANG-GELFFHLSRERVFSEDRARFYGAEIVSAL 275 Query: 156 RHCHN-CGVLHRDIKDENILIDLNRGELKLIDFGSGA--LLKDTVYTDFDGTRVYSPPEW 212 + H+ V++RD+K EN+++D + G +K+ DFG + F GT Y PE Sbjct: 276 DYLHSEKNVVYRDLKLENLMLDKD-GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 334 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRVSSECQHL 266 + + Y GR+ W LG+++Y+M+CG +PF + + I+ ++ F + + E + L Sbjct: 335 LEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSL 393 Query: 267 IRWCLALRPSDRPT-----FEEIQNHPWMQDVLLPQETAEIHLHSLSP 309 + L P R +EI H + ++ + P Sbjct: 394 LSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 441 >5XZW-A nrPDB Length = 471 Score = 254 bits (648), Expect = 5e-68, Method: Composition-based stats. Identities = 75/277 (27%), Positives = 131/277 (47%), Gaps = 32/277 (11%) Query: 40 VGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 99 + ++G G F +V I + A+K + K ++ + N V E+ +L+K++ Sbjct: 200 IDEVVGQGAFATVKKAIERTTGKTFAVKIISKRKV-----IGNMDGVTRELEVLQKLNH- 253 Query: 100 FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 159 ++RL ++E +S+ +++E DL DF+ GA+ E+ R Q+L A+++ H Sbjct: 254 -PRIVRLKGFYEDTESYYMVMEFVSG-GDLMDFVAAHGAVGEDAGREISRQILTAIKYIH 311 Query: 160 NCGVLHRDIKDENILIDLNRGE-LKLIDFGSGA-LLKDTVYTDFDGTRVYSPPEWIRYHR 217 + G+ HRD+K +NILI+ + +K+ DFG + F GT Y PE IR Sbjct: 312 SMGISHRDLKPDNILIEQDDPVLVKITDFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKD 371 Query: 218 ------------YHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQ-- 257 + +WS+G L+Y ++ G +PF ++I RG Sbjct: 372 TSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLK 431 Query: 258 --RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 R+S E + I L + P++R T + NHPW+ D Sbjct: 432 DFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIVD 468 >5D9K-A nrPDB Length = 330 Score = 254 bits (648), Expect = 5e-68, Method: Composition-based stats. Identities = 78/294 (26%), Positives = 141/294 (47%), Gaps = 25/294 (8%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDN---LPVAIKHVEKDRISDWGELPNGTRVPMEVVL 92 SQ+++ +LG G FG V+ ++S + A+K ++K + ++ + R ME + Sbjct: 30 SQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATL----KVRDRVRTKMERDI 85 Query: 93 LKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 L +V+ F +++L F+ LIL+ DLF +++ EE + + ++ Sbjct: 86 LVEVNHPF--IVKLHYAFQTEGKLYLILDFLRG-GDLFTRLSKEVMFTEEDVKFYLAELA 142 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA--LLKDTVYTDFDGTRVYSPP 210 A+ H H+ G+++RD+K ENIL+D G +KL DFG + + F GT Y P Sbjct: 143 LALDHLHSLGIIYRDLKPENILLDEE-GHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAP 201 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRVSSECQ 264 E + R H +SA WS G+L+++M+ G +PF+ + I++ ++ Q +S E Q Sbjct: 202 EVVN-RRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQ 260 Query: 265 HLIRWCLALRPSDRPTF-----EEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK 313 L+R P++R EEI+ H + + + P + Sbjct: 261 SLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGR 314 >2BPM-A nrPDB Length = 309 Score = 254 bits (648), Expect = 5e-68, Method: Composition-based stats. Identities = 74/309 (23%), Positives = 122/309 (39%), Gaps = 48/309 (15%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +Q +G G +G VY VA+K + D ++ + E+ LLK+ Sbjct: 7 ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGV----PSTAIREISLLKE 62 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLE 153 ++ +++LLD + L+ E QDL F+ + L +S+ +Q+L+ Sbjct: 63 LNH--PNIVKLLDVIHTENKLYLVFEFL--HQDLKKFMDASALTGIPLPLIKSYLFQLLQ 118 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPE 211 + CH+ VLHRD+K +N+LI+ G +KL DFG V YT T Y PE Sbjct: 119 GLAFCHSHRVLHRDLKPQNLLINTE-GAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPE 177 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR--------------- 256 + +Y+ + +WSLG + +MV F D EI + FR Sbjct: 178 ILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTS 237 Query: 257 --------------------QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLP 296 + + + L+ L P+ R + + HP+ QDV P Sbjct: 238 MPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKP 297 Query: 297 QETAEIHLH 305 + Sbjct: 298 VPHLRLERP 306 >3BHH-A nrPDB Length = 295 Score = 253 bits (647), Expect = 6e-68, Method: Composition-based stats. Identities = 77/288 (26%), Positives = 127/288 (44%), Gaps = 28/288 (9%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 + +YQ+ +G G F V +++ A K + ++S + ++ E + Sbjct: 2 MTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSAR----DHQKLEREARIC 57 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 + + ++RL D L+ + +LF+ I R E A Q+LE Sbjct: 58 RLLKHS--NIVRLHDSISEEGFHYLVFDLVTG-GELFEDIVAREYYSEADASHCIQQILE 114 Query: 154 AVRHCHNCGVLHRDIKDENILIDL--NRGELKLIDFGSGALLKDTV--YTDFDGTRVYSP 209 AV HCH GV+HRD+K EN+L+ +KL DFG ++ + F GT Y Sbjct: 115 AVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLS 174 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQR----V 259 PE +R Y G+ +W+ G++LY ++ G PF + ++I G F V Sbjct: 175 PEVLRKEAY-GKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTV 233 Query: 260 SSECQHLIRWCLALRPSDRPTFEEIQNHPW------MQDVLLPQETAE 301 + E ++LI L + P+ R T E HPW + ++ QET E Sbjct: 234 TPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVE 281 >2J90-A nrPDB Length = 304 Score = 253 bits (647), Expect = 7e-68, Method: Composition-based stats. Identities = 78/277 (28%), Positives = 127/277 (45%), Gaps = 18/277 (6%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 + +E Y++G LGSG F V + A K ++K R+S + + EV Sbjct: 21 QSMVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREV 80 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQ 150 +L+++ +I L D FE VLILE +LFDF+ E+ +L E+ A F Q Sbjct: 81 NILREIRH--PNIITLHDIFENKTDVVLILELVSG-GELFDFLAEKESLTEDEATQFLKQ 137 Query: 151 VLEAVRHCHNCGVLHRDIKDENILI---DLNRGELKLIDFGSGALLK-DTVYTDFDGTRV 206 +L+ V + H+ + H D+K ENI++ ++ +KLIDFG ++ + + GT Sbjct: 138 ILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPE 197 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF------EHDEEIIRGQVFFRQ--- 257 + PE + Y G A +WS+G++ Y ++ G PF E I F + Sbjct: 198 FVAPEIVNYEPL-GLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYF 256 Query: 258 -RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 S + IR L P R T + H W++ + Sbjct: 257 SNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAI 293 >2YCR-A nrPDB Length = 323 Score = 253 bits (646), Expect = 8e-68, Method: Composition-based stats. Identities = 84/300 (28%), Positives = 142/300 (47%), Gaps = 26/300 (8%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDR--ISDWGELPNGTRVPME 89 + L +Y + LGSG G V VAIK + K + I E V E Sbjct: 6 KALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKFAIGSAREADPALNVETE 65 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 + +LKK++ +I++ ++F+ D + ++LE E +LFD + L+E + +F+ Sbjct: 66 IEILKKLNH--PCIIKIKNFFDAED-YYIVLELMEG-GELFDKVVGNKRLKEATCKLYFY 121 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILID--LNRGELKLIDFGSGALLKDT-VYTDFDGTRV 206 Q+L AV++ H G++HRD+K EN+L+ +K+ DFG +L +T + GT Sbjct: 122 QMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPT 181 Query: 207 YSPPEWI--RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-------EEIIRGQVFFRQ 257 Y PE + + R+ WSLG++L+ + G PF ++I G+ F Sbjct: 182 YLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIP 241 Query: 258 ----RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQE----TAEIHLHSLSP 309 VS + L++ L + P R T EE HPW+QD + ++ +E + + P Sbjct: 242 EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDLLSEENESTAKP 301 >3MV5-A nrPDB Length = 342 Score = 253 bits (646), Expect = 9e-68, Method: Composition-based stats. Identities = 67/288 (23%), Positives = 129/288 (44%), Gaps = 22/288 (7%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 ++++ LLG G FG V + A+K ++K+ I E+ + E +L+ Sbjct: 10 NEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAH---TLTENRVLQ- 65 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 +S + L F+ D ++E +LF ++ E+ AR + +++ A+ Sbjct: 66 -NSRHPFLTALKYSFQTHDRLCFVMEYANG-GELFFHLSRERVFSEDRARFYGAEIVSAL 123 Query: 156 RHCHN-CGVLHRDIKDENILIDLNRGELKLIDFGSGA--LLKDTVYTDFDGTRVYSPPEW 212 + H+ V++RD+K EN+++D + G +K+ DFG + F GT Y PE Sbjct: 124 DYLHSEKNVVYRDLKLENLMLDKD-GHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEV 182 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRVSSECQHL 266 + + Y GR+ W LG+++Y+M+CG +PF + + I+ ++ F + + E + L Sbjct: 183 LEDNDY-GRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSL 241 Query: 267 IRWCLALRPSDRPT-----FEEIQNHPWMQDVLLPQETAEIHLHSLSP 309 + L P R +EI H + ++ + P Sbjct: 242 LSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKP 289 >3UDB-A nrPDB Length = 317 Score = 253 bits (646), Expect = 9e-68, Method: Composition-based stats. Identities = 78/270 (28%), Positives = 119/270 (44%), Gaps = 24/270 (8%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 +Y++ +G+G FG N VA+K++E+ D V E++ + Sbjct: 18 SDRYELVKDIGAGNFGVARLMRDKQANELVAVKYIERGEKID-------ENVKREIINHR 70 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 + ++R + P +++E +LF+ I G E+ AR FF Q++ Sbjct: 71 SLRH--PNIVRFKEVILTPTHLAIVMEYASG-GELFERICNAGRFSEDEARFFFQQLISG 127 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRG-ELKLIDFGSGAL-LKDTVYTDFDGTRVYSPPEW 212 V + H V HRD+K EN L+D + LK+ DFG + + GT Y PE Sbjct: 128 VSYAHAMQVAHRDLKLENTLLDGSPAPRLKIADFGYSKASVLHSQPKSAVGTPAYIAPEV 187 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE----------IIRGQVFFRQ--RVS 260 + Y G+ A VWS G+ LY M+ G PFE EE I+ Q +S Sbjct: 188 LLKKEYDGKVADVWSCGVTLYVMLVGAYPFEDPEEPKNFRKTIHRILNVQYAIPDYVHIS 247 Query: 261 SECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 EC+HLI P+ R + EI+NH W Sbjct: 248 PECRHLISRIFVADPAKRISIPEIRNHEWF 277 >2W4O-A nrPDB Length = 349 Score = 252 bits (645), Expect = 1e-67, Method: Composition-based stats. Identities = 84/297 (28%), Positives = 132/297 (44%), Gaps = 29/297 (9%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 G ++ L ++V LG G VY + P A+K ++K + V Sbjct: 45 GSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTV--------DKKIVR 96 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSF 147 E+ +L ++S +I+L + FE P L+LE +LFD I E+G E A Sbjct: 97 TEIGVLLRLSH--PNIIKLKEIFETPTEISLVLELVTG-GELFDRIVEKGYYSERDAADA 153 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILIDL--NRGELKLIDFGSGALLKDTV-YTDFDGT 204 Q+LEAV + H G++HRD+K EN+L LK+ DFG +++ V GT Sbjct: 154 VKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGT 213 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-------EEIIRGQVFFRQ 257 Y PE +R +G +WS+GI+ Y ++CG PF + I+ + +F Sbjct: 214 PGYCAPEILRG-CAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFIS 272 Query: 258 R----VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV---LLPQETAEIHLHSL 307 VS + L+R + L P R T + HPW+ + +TA+ L Sbjct: 273 PWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEF 329 >4RA4-A nrPDB Length = 355 Score = 252 bits (644), Expect = 1e-67, Method: Composition-based stats. Identities = 71/310 (22%), Positives = 128/310 (41%), Gaps = 30/310 (9%) Query: 13 RAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKD 72 R P N+L KL + +LG G FG V R AIK ++KD Sbjct: 7 RKQPSNNLDRVKLT----------DFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKD 56 Query: 73 RISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDF 132 + ++ +E +L + + +L F+ D ++E DL Sbjct: 57 VVIQDDDVEC---TMVEKRVLALLDKP-PFLTQLHSCFQTVDRLYFVMEYVNG-GDLMYH 111 Query: 133 ITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA- 191 I + G +E A + ++ + H G+++RD+K +N+++D G +K+ DFG Sbjct: 112 IQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSE-GHIKIADFGMCKE 170 Query: 192 -LLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE--- 247 ++ F GT Y PE I Y Y G+S W+ G+LLY+M+ G PF+ ++E Sbjct: 171 HMMDGVTTRTFCGTPDYIAPEIIAYQPY-GKSVDWWAYGVLLYEMLAGQPPFDGEDEDEL 229 Query: 248 ---IIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTF-----EEIQNHPWMQDVLLPQET 299 I+ V + + +S E + + + P+ R +++ H + + + + Sbjct: 230 FQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLE 289 Query: 300 AEIHLHSLSP 309 P Sbjct: 290 NREIQPPFKP 299 >5JZN-A nrPDB Length = 280 Score = 252 bits (644), Expect = 1e-67, Method: Composition-based stats. Identities = 74/274 (27%), Positives = 127/274 (46%), Gaps = 25/274 (9%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 + +Y+VG +G G F V + S A+K ++K + + + EV +L Sbjct: 17 ITERYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEHM-----IQNEVSIL 71 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 ++V ++ L++ + P L++E + DLFD IT E A + + Sbjct: 72 RRVKH--PNIVLLIEEMDVPTELYLVMELVKG-GDLFDAITSTNKYTERDASGMLYNLAS 128 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNR---GELKLIDFGSGALLKDTVYTDFDGTRVYSPP 210 A+++ H+ ++HRDIK EN+L+ ++ LKL DFG ++ +YT GT Y P Sbjct: 129 AIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDGPLYT-VCGTPTYVAP 187 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD--------EEIIRGQVFFR----QR 258 E I +G +W+ G++ Y ++CG PF ++I+ GQV F Sbjct: 188 EIIA-ETGYGLKVDIWAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDN 246 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 VS + LI L + R + ++ HPW+ D Sbjct: 247 VSDSAKELITMMLLVDVDQRFSAVQVLEHPWVND 280 >3GUB-A nrPDB Length = 295 Score = 251 bits (642), Expect = 2e-67, Method: Composition-based stats. Identities = 79/285 (27%), Positives = 130/285 (45%), Gaps = 22/285 (7%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 +E ++ Y G LGSG F V S L A K ++K R + + EV Sbjct: 6 QENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREV 65 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQ 150 +LK++ VI L + +E +LI E +LFDF+ E+ +L EE A F Q Sbjct: 66 SILKEIQH--PNVITLHEVYENKTDVILIGELVAG-GELFDFLAEKESLTEEEATEFLKQ 122 Query: 151 VLEAVRHCHNCGVLHRDIKDENILI---DLNRGELKLIDFGSGALLK-DTVYTDFDGTRV 206 +L V + H+ + H D+K ENI++ ++ + +K+IDFG + + + GT Sbjct: 123 ILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPE 182 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQ--- 257 + PE + Y G A +WS+G++ Y ++ G PF D + + F Sbjct: 183 FVAPEIVNYEPL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYF 241 Query: 258 -RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAE 301 S+ + IR L P R T ++ HPW++ P++T + Sbjct: 242 SNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPWIK----PKDTQQ 282 >2YAB-A nrPDB Length = 361 Score = 251 bits (642), Expect = 2e-67, Method: Composition-based stats. Identities = 84/282 (29%), Positives = 130/282 (46%), Gaps = 18/282 (6%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 89 +++ +E Y +G LGSG F V S L A K ++K + + E Sbjct: 6 KQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIERE 65 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 V +L++V +I L D +E VLILE +LFDF+ ++ +L EE A SF Sbjct: 66 VSILRQVLH--PNIITLHDVYENRTDVVLILELVSG-GELFDFLAQKESLSEEEATSFIK 122 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILI---DLNRGELKLIDFGSGALLKDTV-YTDFDGTR 205 Q+L+ V + H + H D+K ENI++ ++ +KLIDFG ++D V + + GT Sbjct: 123 QILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTP 182 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRV 259 + PE + Y G A +WS+G++ Y ++ G PF D + I F + Sbjct: 183 EFVAPEIVNYEPL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEF 241 Query: 260 ----SSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQ 297 S + IR L R T +E HPW+ V Q Sbjct: 242 FSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPVDTQQ 283 >2Z7Q-A nrPDB Length = 321 Score = 251 bits (642), Expect = 3e-67, Method: Composition-based stats. Identities = 79/302 (26%), Positives = 139/302 (46%), Gaps = 26/302 (8%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRV---SDNLPVAIKHVEKDRISDWGELPNGT 84 G EK S +++ +LG G FG V+ +V A+K ++K + ++ + Sbjct: 21 GSEKADP-SHFELLKVLGQGSFGKVFLVRKVTRPDSGHLYAMKVLKKATL----KVRDRV 75 Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELA 144 R ME +L V+ F V++L F+ LIL+ DLF +++ EE Sbjct: 76 RTKMERDILADVNHPF--VVKLHYAFQTEGKLYLILDFLRG-GDLFTRLSKEVMFTEEDV 132 Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA--LLKDTVYTDFD 202 + + ++ + H H+ G+++RD+K ENIL+D G +KL DFG + + F Sbjct: 133 KFYLAELALGLDHLHSLGIIYRDLKPENILLDEE-GHIKLTDFGLSKEAIDHEKKAYSFC 191 Query: 203 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFR 256 GT Y PE + H SA WS G+L+++M+ G +PF+ + I++ ++ Sbjct: 192 GTVEYMAPEVVNRQG-HSHSADWWSYGVLMFEMLTGSLPFQGKDRKETMTLILKAKLGMP 250 Query: 257 QRVSSECQHLIRWCLALRPSDRP-----TFEEIQNHPWMQDVLLPQETAEIHLHSLSPGP 311 Q +S+E Q L+R P++R EEI+ H + + + P Sbjct: 251 QFLSTEAQSLLRALFKRNPANRLGSGPDGAEEIKRHVFYSTIDWNKLYRREIKPPFKPAV 310 Query: 312 SK 313 ++ Sbjct: 311 AQ 312 >3SOA-A nrPDB Length = 444 Score = 250 bits (640), Expect = 5e-67, Method: Composition-based stats. Identities = 75/272 (27%), Positives = 118/272 (43%), Gaps = 22/272 (8%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 +YQ+ LG G F V ++V A + ++S + ++ E + Sbjct: 9 FTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAMIINTKKLSAR----DHQKLEREARIC 64 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 + + ++RL D LI + +LF+ I R E A Q+LE Sbjct: 65 RLLKH--PNIVRLHDSISEEGHHYLIFDLVTG-GELFEDIVAREYYSEADASHCIQQILE 121 Query: 154 AVRHCHNCGVLHRDIKDENILIDL--NRGELKLIDFGSGALLKDTV--YTDFDGTRVYSP 209 AV HCH GV+HR++K EN+L+ +KL DFG ++ + F GT Y Sbjct: 122 AVLHCHQMGVVHRNLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLS 181 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQR----V 259 PE +R Y G+ +W+ G++LY ++ G PF + ++I G F V Sbjct: 182 PEVLRKDPY-GKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTV 240 Query: 260 SSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 + E + LI L + PS R T E HPW+ Sbjct: 241 TPEAKDLINKMLTINPSKRITAAEALKHPWIS 272 >3I6U-A nrPDB Length = 419 Score = 250 bits (639), Expect = 5e-67, Method: Composition-based stats. Identities = 81/289 (28%), Positives = 139/289 (48%), Gaps = 22/289 (7%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDR--ISDWGELPNGTRVPME 89 + L +Y + LGSG G V VAI+ + K + I E V E Sbjct: 131 KALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIRIISKRKFAIGSAREADPALNVETE 190 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 + +LKK++ +I++ ++F+ D + ++LE E +LFD + L+E + +F+ Sbjct: 191 IEILKKLNH--PCIIKIKNFFDAED-YYIVLELMEG-GELFDKVVGNKRLKEATCKLYFY 246 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILID--LNRGELKLIDFGSGALLKDT-VYTDFDGTRV 206 Q+L AV++ H G++HRD+K EN+L+ +K+ DFG +L +T + GT Sbjct: 247 QMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLCGTPT 306 Query: 207 YSPPEWI--RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-------EEIIRGQVFFRQ 257 Y PE + + R+ WSLG++L+ + G PF ++I G+ F Sbjct: 307 YLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFSEHRTQVSLKDQITSGKYNFIP 366 Query: 258 ----RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEI 302 VS + L++ L + P R T EE HPW+QD + ++ ++ Sbjct: 367 EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDL 415 >3F3Z-A nrPDB Length = 277 Score = 250 bits (639), Expect = 6e-67, Method: Composition-based stats. Identities = 77/280 (27%), Positives = 117/280 (41%), Gaps = 24/280 (8%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 G K + Y + +G G +G V ++ + A K + K + D R Sbjct: 1 GSTKGDINQYYTLENTIGRGSWGEVKIAVQKGTRIRRAAKKIPKYFVEDVD------RFK 54 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSF 147 E+ ++K + +IRL + FE L++E +LF+ + + +E A Sbjct: 55 QEIEIMKSLDH--PNIIRLYETFEDNTDIYLVMELCTG-GELFERVVHKRVFRESDAARI 111 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILI--DLNRGELKLIDFGSGALLK-DTVYTDFDGT 204 VL AV +CH V HRD+K EN L D LKLIDFG A K + GT Sbjct: 112 MKDVLSAVAYCHKLNVAHRDLKPENFLFLTDSPDSPLKLIDFGLAARFKPGKMMRTKVGT 171 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EIIRGQVFFRQR 258 Y P+ + +G WS G+++Y ++CG PF +I G F ++ Sbjct: 172 PYYVSPQVLEG--LYGPECDEWSAGVMMYVLLCGYPPFSAPTDSEVMLKIREGTFTFPEK 229 Query: 259 ----VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVL 294 VS + + LIR L P R T + H W + L Sbjct: 230 DWLNVSPQAESLIRRLLTKSPKQRITSLQALEHEWFEKQL 269 >3TXO-A nrPDB Length = 353 Score = 250 bits (638), Expect = 6e-67, Method: Composition-based stats. Identities = 67/288 (23%), Positives = 124/288 (43%), Gaps = 21/288 (7%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 ++ +LG G FG V A+K ++KD I ++ E +L Sbjct: 23 DNFEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVEC---TMTEKRIL-S 78 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 ++ + +L F+ PD ++E DL I + E AR + +++ A+ Sbjct: 79 LARNHPFLTQLFCCFQTPDRLFFVMEFVNG-GDLMFHIQKSRRFDEARARFYAAEIISAL 137 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA--LLKDTVYTDFDGTRVYSPPEWI 213 H+ G+++RD+K +N+L+D G KL DFG + F GT Y PE + Sbjct: 138 MFLHDKGIIYRDLKLDNVLLDHE-GHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEIL 196 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRVSSECQHLI 267 + +G + W++G+LLY+M+CG PFE + E I+ +V + + + ++ Sbjct: 197 Q-EMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGIL 255 Query: 268 RWCLALRPSDRP-TFEE-----IQNHPWMQDVLLPQETAEIHLHSLSP 309 + + P+ R + + I HP+ +++ Q P Sbjct: 256 KSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRP 303 >3COM-A nrPDB Length = 314 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 72/295 (24%), Positives = 115/295 (38%), Gaps = 29/295 (9%) Query: 11 HLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVE 70 LR P L KL + E + V LG G +GSVY I VAIK V Sbjct: 6 QLRNPPRRQL--KKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVP 63 Query: 71 KDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLF 130 + + + E+ ++++ S V++ + + +++E + Sbjct: 64 VE--------SDLQEIIKEISIMQQCDS--PHVVKYYGSYFKNTDLWIVMEYC-GAGSVS 112 Query: 131 DFIT-ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGS 189 D I L E+ + L+ + + H +HRDIK NIL++ G KL DFG Sbjct: 113 DIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTE-GHAKLADFGV 171 Query: 190 GALLKDTV--YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE 247 L DT+ GT + PE I+ Y+ + +WSLGI +M G P+ D Sbjct: 172 AGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVA-DIWSLGITAIEMAEGKPPY-ADIH 229 Query: 248 IIRGQVFFRQR----------VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 +R S ++ CL P R T ++ HP+++ Sbjct: 230 PMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRS 284 >2Y7J-A nrPDB Length = 365 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 83/314 (26%), Positives = 141/314 (44%), Gaps = 27/314 (8%) Query: 2 LLSKINSLAHLRAAPCNDLHATKLAPGKE------KEPLESQYQVGPLLGSGGFGSVYSG 55 LL++ L + +L+ + P E + +Y ++G G V Sbjct: 54 LLAEAKKLNDAQPKGTENLYFQSMGPEDELPDWAAAKEFYQKYDPKDVIGRGVSSVVRRC 113 Query: 56 IRVSDNLPVAIKHVE--KDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERP 113 + + A+K +E +R+S E +L++V +G +I L+D +E Sbjct: 114 VHRATGHEFAVKIMEVTAERLSPEQLEEVREATRRETHILRQV-AGHPHIITLIDSYESS 172 Query: 114 DSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENI 173 L+ + +LFD++TE+ AL E+ RS +LEAV H ++HRD+K ENI Sbjct: 173 SFMFLVFDLMRK-GELFDYLTEKVALSEKETRSIMRSLLEAVSFLHANNIVHRDLKPENI 231 Query: 174 LIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRVYSPPEWIR-----YHRYHGRSAAVWS 227 L+D N +++L DFG L+ + GT Y PE ++ H +G+ +W+ Sbjct: 232 LLDDNM-QIRLSDFGFSCHLEPGEKLRELCGTPGYLAPEILKCSMDETHPGYGKEVDLWA 290 Query: 228 LGILLYDMVCGDIPFEHDEE------IIRGQVFFR----QRVSSECQHLIRWCLALRPSD 277 G++L+ ++ G PF H + I+ GQ F SS + LI L + P Sbjct: 291 CGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSSTVKDLISRLLQVDPEA 350 Query: 278 RPTFEEIQNHPWMQ 291 R T E+ HP+ + Sbjct: 351 RLTAEQALQHPFFE 364 >1VZO-A nrPDB Length = 355 Score = 248 bits (634), Expect = 2e-66, Method: Composition-based stats. Identities = 78/316 (24%), Positives = 140/316 (44%), Gaps = 28/316 (8%) Query: 16 PCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRV---SDNLPVAIKHVEKD 72 ++L L EK +E+ +++ +LG+G +G V+ ++ A+K ++K Sbjct: 35 VKHELRTANLTGHAEKVGIEN-FELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKA 93 Query: 73 RISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDF 132 I + TR E +L+ + ++ L F+ LIL+ +LF Sbjct: 94 TIVQKAKTTEHTRT--ERQVLEHIRQS-PFLVTLHYAFQTETKLHLILDYING-GELFTH 149 Query: 133 ITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL 192 +++R E + + +++ A+ H H G+++RDIK ENIL+D N G + L DFG Sbjct: 150 LSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSN-GHVVLTDFGLSKE 208 Query: 193 L---KDTVYTDFDGTRVYSPPEWIR-YHRYHGRSAAVWSLGILLYDMVCGDIPFEHD--- 245 + DF GT Y P+ +R H ++ WSLG+L+Y+++ G PF D Sbjct: 209 FVADETERAYDFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEK 268 Query: 246 -------EEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPT-----FEEIQNHPWMQDV 293 I++ + + Q +S+ + LI+ L P R +EI+ H + Q + Sbjct: 269 NSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKI 328 Query: 294 LLPQETAEIHLHSLSP 309 A+ P Sbjct: 329 NWDDLAAKKVPAPFKP 344 >4C0T-A nrPDB Length = 974 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 83/293 (28%), Positives = 136/293 (46%), Gaps = 26/293 (8%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 + ++ G LG G + +V A+K ++K I ++ V +E L + Sbjct: 266 TDFKFGKELGEGSYSTVILATDKITGKQYAVKVLDKRHIIKEKKVKY---VNIEKHALNR 322 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 +S+ GVI L F+ DS +L+ +L I L EE R F Q+L+A+ Sbjct: 323 LSNRL-GVISLYFTFQDKDSLYFVLDYASN-GELLTLIKRYNTLNEECTRHFGAQILDAI 380 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-----------DTVYTDFDGT 204 ++ H+ GV+HRD+K ENIL+D ++ +++ DFG+ LL+ D F GT Sbjct: 381 KYMHDNGVIHRDLKPENILLD-DKMRIQITDFGTARLLEKKNDESEEYPVDVRAKSFVGT 439 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQR 258 Y PE + ++Y G+ VW+ G ++Y M+ G PF+ ++I + Q F Sbjct: 440 AEYVSPELLE-NKYCGKPGDVWAFGCIIYQMIAGKPPFKATNEYLTFQKITKLQFAFSAG 498 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAE--IHLHSLSP 309 + + LI+ L L+PS R T EIQ H + Q V + + P Sbjct: 499 FPTIIRDLIKKILVLQPSRRATIPEIQKHYFFQSVDFKDFDSIWLSDPPEIGP 551 >2A27-A nrPDB Length = 321 Score = 248 bits (633), Expect = 3e-66, Method: Composition-based stats. Identities = 84/278 (30%), Positives = 130/278 (46%), Gaps = 18/278 (6%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 89 +++ +E Y +G LGSG F V S L A K ++K + + + E Sbjct: 6 KQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIERE 65 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 V +L++V VI L D +E VLILE +LFDF+ ++ +L EE A SF Sbjct: 66 VSILRQVLHH--NVITLHDVYENRTDVVLILELVSG-GELFDFLAQKESLSEEEATSFIK 122 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILI---DLNRGELKLIDFGSGALLKDTV-YTDFDGTR 205 Q+L+ V + H + H D+K ENI++ ++ +KLIDFG ++D V + + GT Sbjct: 123 QILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTP 182 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRV 259 + PE + Y G A +WS+G++ Y ++ G PF D + I F + Sbjct: 183 EFVAPEIVNYEPL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEF 241 Query: 260 ----SSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 S + IR L R T +E HPW+ V Sbjct: 242 FSQTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPV 279 >1ZWS-A nrPDB Length = 288 Score = 247 bits (631), Expect = 5e-66, Method: Composition-based stats. Identities = 84/278 (30%), Positives = 130/278 (46%), Gaps = 18/278 (6%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 89 +++ +E Y +G LGSG F V S L A K ++K + + + E Sbjct: 6 KQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVSREEIERE 65 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 V +L++V VI L D +E VLILE +LFDF+ ++ +L EE A SF Sbjct: 66 VSILRQVLHH--NVITLHDVYENRTDVVLILELVSG-GELFDFLAQKESLSEEEATSFIK 122 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILI---DLNRGELKLIDFGSGALLKDTV-YTDFDGTR 205 Q+L+ V + H + H D+K ENI++ ++ +KLIDFG ++D V + + GT Sbjct: 123 QILDGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTP 182 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQ-- 257 + PE + Y G A +WS+G++ Y ++ G PF D + I F + Sbjct: 183 EFVAPEIVNYEPL-GLEADMWSIGVITYILLSGASPFLGDTKQETLANITSVSYDFDEEF 241 Query: 258 --RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 S + IR L R T +E HPW+ V Sbjct: 242 FSHTSELAKDFIRKLLVKETRKRLTIQEALRHPWITPV 279 >4JXF-A nrPDB Length = 266 Score = 247 bits (630), Expect = 6e-66, Method: Composition-based stats. Identities = 76/265 (28%), Positives = 123/265 (46%), Gaps = 17/265 (6%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 ++VG LLG G F VY + L VAIK ++K + G + RV EV + + Sbjct: 7 EDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMV---QRVQNEVKIHCQ 63 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER-GALQEELARSFFWQVLEA 154 + ++ L ++FE + L+LE ++ ++ R E AR F Q++ Sbjct: 64 LKH--PSILELYNYFEDSNYVYLVLEMCHN-GEMNRYLKNRVKPFSENEARHFMHQIITG 120 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPEW 212 + + H+ G+LHRD+ N+L+ N +K+ DFG LK + GT Y PE Sbjct: 121 MLYLHSHGILHRDLTLSNLLLTRNMN-IKIADFGLATQLKMPHEKHYTLCGTPNYISPE- 178 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHL 266 I HG + VWSLG + Y ++ G PF+ D +++ +S E + L Sbjct: 179 IATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDL 238 Query: 267 IRWCLALRPSDRPTFEEIQNHPWMQ 291 I L P+DR + + +HP+M Sbjct: 239 IHQLLRRNPADRLSLSSVLDHPFMS 263 >4PDS-A nrPDB Length = 347 Score = 247 bits (630), Expect = 6e-66, Method: Composition-based stats. Identities = 72/276 (26%), Positives = 130/276 (47%), Gaps = 32/276 (11%) Query: 40 VGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 99 + ++G G F +V I + ++K + K ++ + N V E+ +L+K++ Sbjct: 35 IDEVVGQGAFATVKKAIERTTGKTFSVKIISKRKV-----IGNMDGVTRELEVLQKLNH- 88 Query: 100 FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 159 ++RL ++E +S+ +++E DL DF+ GA+ E+ R Q+L A+++ H Sbjct: 89 -PRIVRLKGFYEDTESYYMVMEFVSG-GDLMDFVAAHGAVGEDAGREISRQILTAIKYIH 146 Query: 160 NCGVLHRDIKDENILIDLNRGE-LKLIDFGSGA-LLKDTVYTDFDGTRVYSPPEWIRYHR 217 + G+ HRD+K +NILI+ + +K+ FG + F GT Y PE IR Sbjct: 147 SMGISHRDLKPDNILIEQDDPVLVKITAFGLAKVQGNGSFMKTFCGTLAYVAPEVIRGKD 206 Query: 218 ------------YHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQ-- 257 + +WS+G L+Y ++ G +PF ++I RG Sbjct: 207 TSVSPDEYEERNEYSSLVDMWSMGCLVYVILTGHLPFSGSTQDQLYKQIGRGSYHEGPLK 266 Query: 258 --RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 R+S E + I L + P++R T + NHPW++ Sbjct: 267 DFRISEEARDFIDSLLQVDPNNRSTAAKALNHPWIK 302 >3DB8-A nrPDB Length = 317 Score = 246 bits (629), Expect = 8e-66, Method: Composition-based stats. Identities = 69/277 (24%), Positives = 116/277 (41%), Gaps = 16/277 (5%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +Y G LG GGF Y + A K V K + + ++ E+ + K Sbjct: 42 KRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQ---KEKMSTEIAIHKS 98 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 + + V+ +FE D ++LE + L + R A+ E AR F Q ++ V Sbjct: 99 LDN--PHVVGFHGFFEDDDFVYVVLEICR-RRSLLELHKRRKAVTEPEARYFMRQTIQGV 155 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPEWI 213 ++ HN V+HRD+K N+ ++ + ++K+ DFG ++ D GT Y PE + Sbjct: 156 QYLHNNRVIHRDLKLGNLFLNDDM-DVKIGDFGLATKIEFDGERKKDLCGTPNYIAPEVL 214 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLI 267 + H +WSLG +LY ++ G PFE I + + + ++ LI Sbjct: 215 -CKKGHSFEVDIWSLGCILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHINPVASALI 273 Query: 268 RWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHL 304 R L P+ RP+ E+ + P L Sbjct: 274 RRMLHADPTLRPSVAELLTDEFFTSGYAPMRLPTSCL 310 >4L42-A nrPDB Length = 346 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 74/290 (25%), Positives = 135/290 (46%), Gaps = 23/290 (7%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVS---DNLPVAIKHVEKDRISDWGELPNGTRVPMEVVL 92 +++ +LG GG+G V+ +V+ A+K ++K I + T+ E + Sbjct: 18 ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKA--ERNI 75 Query: 93 LKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 L++V F ++ L+ F+ LILE +LF + G E+ A + ++ Sbjct: 76 LEEVKHPF--IVDLIYAFQTGGKLYLILEYLSG-GELFMQLEREGIFMEDTACFYLAEIS 132 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA--LLKDTVYTDFDGTRVYSPP 210 A+ H H G+++RD+K ENI+++ +G +KL DFG + TV F GT Y P Sbjct: 133 MALGHLHQKGIIYRDLKPENIMLNH-QGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAP 191 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQ 264 E + ++ R+ WSLG L+YDM+ G PF + ++I++ ++ ++ E + Sbjct: 192 EILMRSGHN-RAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEAR 250 Query: 265 HLIRWCLALRPSDRPT-----FEEIQNHPWMQDVLLPQETAEIHLHSLSP 309 L++ L + R E+Q HP+ + + + A P Sbjct: 251 DLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 300 >5F9E-A nrPDB Length = 353 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 67/296 (22%), Positives = 127/296 (42%), Gaps = 16/296 (5%) Query: 23 TKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPN 82 K P + + +++ +LG G FG V+ N AIK ++KD + ++ Sbjct: 6 NKERPSLQIKLKIEDFELHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDDDVEC 65 Query: 83 GTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEE 142 +E +L ++ + + F+ ++ ++E DL I Sbjct: 66 ---TMVEKRVL-SLAWEHPFLTHMFCTFQTKENLFFVMEYLNG-GDLMYHIQSCHKFDLS 120 Query: 143 LARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA--LLKDTVYTD 200 A + +++ ++ H+ G+++RD+K +NIL+D + G +K+ DFG +L D + Sbjct: 121 RATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKD-GHIKIADFGMCKENMLGDAKTNE 179 Query: 201 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVF 254 F GT Y PE + +Y+ S WS G+LLY+M+ G PF +E I F Sbjct: 180 FCGTPDYIAPEILLGQKYN-HSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPF 238 Query: 255 FRQRVSSECQHLIRWCLALRPSDRPTFE-EIQNHPWMQDVLLPQETAEIHLHSLSP 309 + + + E + L+ P R +I+ HP +++ + + P Sbjct: 239 YPRWLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRP 294 >3TAC-A nrPDB Length = 361 Score = 245 bits (627), Expect = 1e-65, Method: Composition-based stats. Identities = 69/281 (24%), Positives = 125/281 (44%), Gaps = 20/281 (7%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 + E Y++ ++G G F V I A+K V+ + + L + Sbjct: 18 ADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLST-EDLK 76 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA---LQEELA 144 E + + ++ LL+ + ++ E + F+ + A E +A Sbjct: 77 REASICHMLKH--PHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVA 134 Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILI--DLNRGELKLIDFGSGALLKDT--VYTD 200 + Q+LEA+R+CH+ ++HRD+K +L+ N +KL FG L ++ V Sbjct: 135 SHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGG 194 Query: 201 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE-----IIRGQVFF 255 GT + PE ++ Y G+ VW G++L+ ++ G +PF +E II+G+ Sbjct: 195 RVGTPHFMAPEVVKREPY-GKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKM 253 Query: 256 RQR----VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 R +S + L+R L L P++R T E NHPW+++ Sbjct: 254 NPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKE 294 >3HDN-A nrPDB Length = 373 Score = 245 bits (626), Expect = 2e-65, Method: Composition-based stats. Identities = 67/301 (22%), Positives = 126/301 (41%), Gaps = 19/301 (6%) Query: 21 HATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGEL 80 L P S + ++G G FG V ++ + A+K ++K I E Sbjct: 23 QQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEE 82 Query: 81 PNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQ 140 + + E +L K + ++ L F+ D +L+ +LF + Sbjct: 83 KH---IMSERNVLLK-NVKHPFLVGLHFSFQTADKLYFVLDYING-GELFYHLQRERCFL 137 Query: 141 EELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA--LLKDTVY 198 E AR + ++ A+ + H+ +++RD+K ENIL+D +G + L DFG + ++ Sbjct: 138 EPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDS-QGHIVLTDFGLCKENIEHNSTT 196 Query: 199 TDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF------EHDEEIIRGQ 252 + F GT Y PE + Y R+ W LG +LY+M+ G PF E + I+ Sbjct: 197 STFCGTPEYLAPEVLHKQPY-DRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKP 255 Query: 253 VFFRQRVSSECQHLIRWCLALRPSDRPTFE----EIQNHPWMQDVLLPQETAEIHLHSLS 308 + + +++ +HL+ L + R + EI++H + + + + Sbjct: 256 LQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHVFFSLINWDDLINKKITPPFN 315 Query: 309 P 309 P Sbjct: 316 P 316 >4I6B-A nrPDB Length = 308 Score = 245 bits (625), Expect = 2e-65, Method: Composition-based stats. Identities = 70/280 (25%), Positives = 124/280 (44%), Gaps = 16/280 (5%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +Y G LG GGF Y +++N A K + R+S + ++ E+ L + Sbjct: 28 KRYSRGKTLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVSKPHQ---REKIDKEIELHRI 84 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 + V++ +FE ++ ++LE + + + R L E R + Q++ + Sbjct: 85 LHHKH--VVQFYHYFEDKENIYILLEYCS-RRSMAHILKARKVLTEPEVRYYLRQIVSGL 141 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPEWI 213 ++ H +LHRD+K N I+ + ELK+ DFG A L+ + GT Y PE + Sbjct: 142 KYLHEQEILHRDLKLGNFFINESM-ELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVL 200 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EIIRGQVFFRQRVSSECQHLI 267 HG + +W+LG ++Y M+ G PFE I + + + +HLI Sbjct: 201 NKQG-HGAESDIWALGCVMYTMLLGRPPFETTNLKETYRSIREARYTMPSSLLAPAKHLI 259 Query: 268 RWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSL 307 L+ P DRP+ ++I H + P + H++ Sbjct: 260 ASMLSKNPEDRPSLDDIIRHDFFTQGFTPDRLSSSCCHTV 299 >1PHK-A nrPDB Length = 298 Score = 245 bits (625), Expect = 2e-65, Method: Composition-based stats. Identities = 79/294 (26%), Positives = 125/294 (42%), Gaps = 22/294 (7%) Query: 23 TKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKD---RISDWGE 79 L Y+ +LG G V I A+K ++ S Sbjct: 4 AALPGSHSTHGFYENYEPKEILGRGVSSVVRRCIHKPTCKEYAVKIIDVTGGGSFSAEEV 63 Query: 80 LPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGAL 139 EV +L+KVS G +I+L D +E F L+ + + +LFD++TE+ L Sbjct: 64 QELREATLKEVDILRKVS-GHPNIIQLKDTYETNTFFFLVFDLMKK-GELFDYLTEKVTL 121 Query: 140 QEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVY 198 E+ R +LE + H ++HRD+K ENIL+D + +KL DFG L Sbjct: 122 SEKETRKIMRALLEVICALHKLNIVHRDLKPENILLDDDMN-IKLTDFGFSCQLDPGEKL 180 Query: 199 TDFDGTRVYSPPEWIR-----YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------ 247 + GT Y PE I H +G+ +WS G+++Y ++ G PF H ++ Sbjct: 181 REVCGTPSYLAPEIIECSMNDNHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRM 240 Query: 248 IIRGQVFFR----QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQ 297 I+ G F S + L+ L ++P R T EE HP+ Q ++ + Sbjct: 241 IMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQKRYTAEEALAHPFFQQYVVEE 294 >3PFQ-A nrPDB Length = 674 Score = 244 bits (623), Expect = 4e-65, Method: Composition-based stats. Identities = 67/308 (21%), Positives = 127/308 (41%), Gaps = 21/308 (6%) Query: 15 APCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRI 74 N + +++ L + +LG G FG V R + A+K ++KD + Sbjct: 321 KTANTISKFDNNGNRDRMKLTD-FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVV 379 Query: 75 SDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT 134 ++ +E +L + + +L F+ D ++E DL I Sbjct: 380 IQDDDVEC---TMVEKRVLA-LPGKPPFLTQLHSCFQTMDRLYFVMEYVNG-GDLMYHIQ 434 Query: 135 ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA--L 192 + G +E A + ++ + + G+++RD+K +N+++D G +K+ DFG + Sbjct: 435 QVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE-GHIKIADFGMCKENI 493 Query: 193 LKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE----- 247 F GT Y PE I Y Y G+S W+ G+LLY+M+ G PFE ++E Sbjct: 494 WDGVTTKTFCGTPDYIAPEIIAYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQ 552 Query: 248 -IIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTF-----EEIQNHPWMQDVLLPQETAE 301 I+ V + + +S E + + + P R +I+ H + + + + + Sbjct: 553 SIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERK 612 Query: 302 IHLHSLSP 309 P Sbjct: 613 EIQPPYKP 620 >4RLP-A nrPDB Length = 288 Score = 244 bits (623), Expect = 4e-65, Method: Composition-based stats. Identities = 74/290 (25%), Positives = 135/290 (46%), Gaps = 23/290 (7%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVS---DNLPVAIKHVEKDRISDWGELPNGTRVPMEVVL 92 +++ +LG GG+G V+ +V+ A+K ++K I + T+ E + Sbjct: 5 ECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKA--ERNI 62 Query: 93 LKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 L++V F ++ L+ F+ LILE +LF + G E+ A + ++ Sbjct: 63 LEEVKHPF--IVDLIYAFQTGGKLYLILEYLSG-GELFMQLEREGIFMEDTACFYLAEIS 119 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA--LLKDTVYTDFDGTRVYSPP 210 A+ H H G+++RD+K ENI+++ +G +KL DFG + TV F GT Y P Sbjct: 120 MALGHLHQKGIIYRDLKPENIMLNH-QGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAP 178 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQ 264 E + ++ R+ WSLG L+YDM+ G PF + ++I++ ++ ++ E + Sbjct: 179 EILMRSGHN-RAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEAR 237 Query: 265 HLIRWCLALRPSDRPT-----FEEIQNHPWMQDVLLPQETAEIHLHSLSP 309 L++ L + R E+Q HP+ + + + A P Sbjct: 238 DLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKP 287 >4B6L-A nrPDB Length = 281 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 75/278 (26%), Positives = 117/278 (42%), Gaps = 16/278 (5%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 Y G LLG GGF Y A+K + + R++ + ++ E+ L + + Sbjct: 11 YLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQ---REKILNEIELHRDLQ 67 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 ++R FE D+ + LE + L R L E R + Q+L +++ Sbjct: 68 HRH--IVRFSHHFEDADNIYIFLELCS-RKSLAHIWKARHTLLEPEVRYYLRQILSGLKY 124 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPEWIRY 215 H G+LHRD+K N I N ELK+ DFG A L+ + GT Y PE + Sbjct: 125 LHQRGILHRDLKLGNFFITENM-ELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLR 183 Query: 216 HRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EIIRGQVFFRQRVSSECQHLIRW 269 HG A VWSLG ++Y ++CG PFE + I + +S + L+ Sbjct: 184 QG-HGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAA 242 Query: 270 CLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSL 307 L P DRP+ ++I H + P ++ Sbjct: 243 ILRASPRDRPSIDQILRHDFFTKGYTPDRLPISSCVTV 280 >3NYO-A nrPDB Length = 576 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 80/338 (23%), Positives = 140/338 (41%), Gaps = 35/338 (10%) Query: 2 LLSKINSLAH--LRAAP----CNDLHATKLAPGK--EKEPLESQ-YQVGPLLGSGGFGSV 52 L ++ L H L AP + ++ + K E++P+ ++ +LG GGFG V Sbjct: 141 LFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEV 200 Query: 53 YSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFER 112 + + A +K + E +L+KV+S F V+ L +E Sbjct: 201 CACQVRATGKMYA---CKKLEKKRIKKRKGEAMALNEKQILEKVNSRF--VVSLAYAYET 255 Query: 113 PDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKD 170 D+ L+L DL I G E A + ++ + H +++RD+K Sbjct: 256 KDALCLVLTLMNG-GDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKP 314 Query: 171 ENILIDLNRGELKLIDFGSGALL-KDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLG 229 ENIL+D + G +++ D G + + GT Y PE ++ RY S W+LG Sbjct: 315 ENILLD-DHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERY-TFSPDWWALG 372 Query: 230 ILLYDMVCGDIPFEHDEEIIRGQVFFR----------QRVSSECQHLIRWCLALRPSDRP 279 LLY+M+ G PF+ ++ I+ + R +R S + + L L P++R Sbjct: 373 CLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERL 432 Query: 280 -----TFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPS 312 + E++ HP + + + A + P P Sbjct: 433 GCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQ 470 >4CSV-A nrPDB Length = 275 Score = 242 bits (618), Expect = 2e-64, Method: Composition-based stats. Identities = 72/284 (25%), Positives = 125/284 (44%), Gaps = 27/284 (9%) Query: 27 PGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRV 86 P + E S+ + LGSG FG VY G + N+ VA+K +++ +S Sbjct: 2 PHDKWEIPRSEITLERKLGSGQFGEVYEGKWRNYNIEVAVKTLKEGTMS-------VEEF 54 Query: 87 PMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT--ERGALQEELA 144 E ++KK+ +++L + +I E L D++ E + + Sbjct: 55 LQEAQIMKKLKH--PNLVQLYGVCTKEPPIYIITEYMS-HGSLLDYLRDCEGHTVNAQAL 111 Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGT 204 QV + + + +HRD+ N L+ N +K+ DFG L+ + YT G Sbjct: 112 LDMAAQVASGMAYLESQNFIHRDLAARNCLVGEN-NVVKVADFGLARLINEDEYTARAGA 170 Query: 205 RV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH------DEEIIRGQVF 254 + ++ PE I Y+R+ +S VW+ GILL+++ G +P+ E++ RG Sbjct: 171 KFPIKWTAPEAISYNRFSIKS-DVWAFGILLWEIFTYGQVPYPGMSGSEVIEQVERGYRM 229 Query: 255 FRQR-VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQ 297 R + E L+ C P +RPTF E H ++ + LP+ Sbjct: 230 PRPQGCPEEIYELMLQCWNKSPEERPTFAETL-HA-LETMFLPE 271 >2I0E-A nrPDB Length = 353 Score = 241 bits (616), Expect = 3e-64, Method: Composition-based stats. Identities = 67/305 (21%), Positives = 127/305 (41%), Gaps = 21/305 (6%) Query: 18 NDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDW 77 N + +++ L + +LG G FG V R + A+K ++KD + Sbjct: 3 NTVSKFDNNGNRDRMKLTD-FNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQD 61 Query: 78 GELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG 137 ++ +E +L + + +L F+ D ++E DL I + G Sbjct: 62 DDVEC---TMVEKRVLA-LPGKPPFLTQLHSCFQTMDRLYFVMEYVNG-GDLMYHIQQVG 116 Query: 138 ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA--LLKD 195 +E A + ++ + + G+++RD+K +N+++D G +K+ DFG + Sbjct: 117 RFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSE-GHIKIADFGMCKENIWDG 175 Query: 196 TVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------II 249 F GT Y PE I Y Y G+S W+ G+LLY+M+ G PFE ++E I+ Sbjct: 176 VTTKTFCGTPDYIAPEIIAYQPY-GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIM 234 Query: 250 RGQVFFRQRVSSECQHLIRWCLALRPSDRPTF-----EEIQNHPWMQDVLLPQETAEIHL 304 V + + +S E + + + P R +I+ H + + + + + Sbjct: 235 EHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQ 294 Query: 305 HSLSP 309 P Sbjct: 295 PPYKP 299 >4NIF-A nrPDB Length = 333 Score = 240 bits (614), Expect = 5e-64, Method: Composition-based stats. Identities = 68/283 (24%), Positives = 112/283 (39%), Gaps = 32/283 (11%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 Y V +G G + + + N+ A+K ++K + E+ +L Sbjct: 6 FSDGYVVKETIGVGSYSECKRCVHKATNMEYAVKVIDKSKRDPSE----------EIEIL 55 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 + +I L D ++ L+ E +L D I + E A + + Sbjct: 56 LRYG-QHPNIITLKDVYDDGKHVYLVTELMRG-GELLDKILRQKFFSEREASFVLHTIGK 113 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRGE---LKLIDFGSGALLK--DTVYTDFDGTRVYS 208 V + H+ GV+HRD+K NIL G L++ DFG L+ + + T + Sbjct: 114 TVEYLHSQGVVHRDLKPSNILYVDESGNPECLRICDFGFAKQLRAENGLLMTPCYTANFV 173 Query: 209 PPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR------------ 256 PE ++ Y +WSLGILLY M+ G PF + ++ R Sbjct: 174 APEVLKRQGY-DEGCDIWSLGILLYTMLAGYTPFANGPSDTPEEILTRIGSGKFTLSGGN 232 Query: 257 -QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM-QDVLLPQ 297 VS + L+ L + P R T +++ HPW+ Q LPQ Sbjct: 233 WNTVSETAKDLVSKMLHVDPHQRLTAKQVLQHPWVTQKDKLPQ 275 >4LG4-A nrPDB Length = 299 Score = 240 bits (613), Expect = 6e-64, Method: Composition-based stats. Identities = 64/274 (23%), Positives = 112/274 (40%), Gaps = 27/274 (9%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVV 91 + E + V LG G +GSV+ I VAIK V + + + E+ Sbjct: 7 KQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE--------SDLQEIIKEIS 58 Query: 92 LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT-ERGALQEELARSFFWQ 150 ++++ S + V++ + + +++E + D I L E+ + Sbjct: 59 IMQQCDSPY--VVKYYGSYFKNTDLWIVMEYC-GAGSVSDIIRLRNKTLIEDEIATILKS 115 Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYS 208 L+ + + H +HR+IK NIL++ G KL DFG L DT+ GT + Sbjct: 116 TLKGLEYLHFMRKIHRNIKAGNILLNTE-GHAKLADFGVAGQLTDTMAKRNTVIGTPFWM 174 Query: 209 PPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR---------- 258 PE I+ Y+ + +WSLGI +M G P+ D +R Sbjct: 175 APEVIQEIGYNCVA-DIWSLGITSIEMAEGKPPY-ADIHPMRAIFMIPTNPPPTFRKPEL 232 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 S + ++ CL P R T ++ HP++++ Sbjct: 233 WSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKN 266 >3IS5-A nrPDB Length = 285 Score = 240 bits (613), Expect = 6e-64, Method: Composition-based stats. Identities = 72/275 (26%), Positives = 124/275 (45%), Gaps = 26/275 (9%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 ++ + LGSG FG V+ S L IK + KDR E ++ E+ +L Sbjct: 20 IDDLFIFKRKLGSGAFGDVHLVEERSSGLERVIKTINKDRSQVPME-----QIEAEIEVL 74 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT----ERGALQEELARSFFW 149 K + +I++ + FE + +++E E +L + I AL E Sbjct: 75 KSLDH--PNIIKIFEVFEDYHNMYIVMETCEG-GELLERIVSAQARGKALSEGYVAELMK 131 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGE--LKLIDFGSGALLK-DTVYTDFDGTRV 206 Q++ A+ + H+ V+H+D+K ENIL +K+IDFG L K D T+ GT + Sbjct: 132 QMMNALAYFHSQHVVHKDLKPENILFQDTSPHSPIKIIDFGLAELFKSDEHSTNAAGTAL 191 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD--EEIIRGQVFFRQRVSSECQ 264 Y PE + R +WS G+++Y ++ G +PF EE+ + + + EC+ Sbjct: 192 YMAPEV--FKRDVTFKCDIWSAGVVMYFLLTGCLPFTGTSLEEVQQKATYKEPNYAVECR 249 Query: 265 -------HLIRWCLALRPSDRPTFEEIQNHPWMQD 292 L++ L P RP+ ++ +H W + Sbjct: 250 PLTPQAVDLLKQMLTKDPERRPSAAQVLHHEWFKQ 284 >2HW6-A nrPDB Length = 307 Score = 240 bits (612), Expect = 7e-64, Method: Composition-based stats. Identities = 77/311 (24%), Positives = 125/311 (40%), Gaps = 53/311 (17%) Query: 22 ATKLAPGKEKEPLESQYQV-GPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGEL 80 +T PGK E Y++ LLG G + V + + + A+K +EK Sbjct: 2 STDSLPGK----FEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGH----- 52 Query: 81 PNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQ 140 + +RV EV L + G ++ L+++FE F L+ E+ + + I ++ Sbjct: 53 -SRSRVFREVETLYQCQ-GNKNILELIEFFEDDTRFYLVFEKLQG-GSILAHIQKQKHFN 109 Query: 141 EELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE--LKLIDFGSGALLK---- 194 E A V A+ H G+ HRD+K ENIL + +K+ DF G+ +K Sbjct: 110 EREASRVVRDVAAALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNS 169 Query: 195 -----DTVYTDFDGTRVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVCGDIPFEHD 245 T G+ Y PE + ++ + +WSLG++LY M+ G PF Sbjct: 170 CTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGH 229 Query: 246 ---------------------EEIIRGQVFFRQR----VSSECQHLIRWCLALRPSDRPT 280 E I G+ F + +SSE + LI L R + Sbjct: 230 CGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLS 289 Query: 281 FEEIQNHPWMQ 291 ++ HPW+Q Sbjct: 290 AAQVLQHPWVQ 300 >6FD3-A nrPDB Length = 300 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 64/269 (23%), Positives = 128/269 (47%), Gaps = 25/269 (9%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 + +Y +G G G+VY+ + ++ VAIK + + P + E+++++ Sbjct: 21 KKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN------LQQQPKKELIINEILVMR 74 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 + + ++ LD + D +++E L D +TE + E + + L+A Sbjct: 75 ENKN--PNIVNYLDSYLVGDELWVVMEYLAG-GSLTDVVTETC-MDEGQIAAVCRECLQA 130 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYTDFDGTRVYSPPEW 212 + H+ V+HRDIK +NIL+ ++ G +KL DFG A + + + + GT + PE Sbjct: 131 LDFLHSNQVIHRDIKSDNILLGMD-GSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEV 189 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF----------RQRVSSE 262 + + +G +WSLGI+ +MV G+ P+ +E +R +R+S+ Sbjct: 190 V-TRKAYGPKVDIWSLGIMAIEMVEGEPPY-LNENPLRALYLIATNGTPELQNPERLSAV 247 Query: 263 CQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 + + CL + R + +E+ HP+++ Sbjct: 248 FRDFLNRCLEMDVDRRGSAKELLQHPFLK 276 >2OU7-A nrPDB Length = 335 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 67/280 (23%), Positives = 113/280 (40%), Gaps = 19/280 (6%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 LG GGF + A K V K + + ++ ME+ + + ++ V Sbjct: 49 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQ---REKMSMEISIHRSLAHQH--V 103 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGV 163 + +FE D ++LE + L + R AL E AR + Q++ ++ H V Sbjct: 104 VGFHGFFEDNDFVFVVLELCR-RRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 162 Query: 164 LHRDIKDENILIDLNRGELKLIDFGSGAL--LKDTVYTDFDGTRVYSPPEWIRYHRYHGR 221 +HRD+K N+ ++ + E+K+ DFG GT Y PE + + H Sbjct: 163 IHRDLKLGNLFLNEDL-EVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLS-KKGHSF 220 Query: 222 SAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRWCLALRP 275 VWS+G ++Y ++ G PFE I + + + ++ LI+ L P Sbjct: 221 EVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDP 280 Query: 276 SDRPTFEEIQNHPWMQDVLLPQETAEIHL---HSLSPGPS 312 + RPT E+ N + +P L S PS Sbjct: 281 TARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPS 320 >4B8L-A nrPDB Length = 286 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 73/276 (26%), Positives = 126/276 (45%), Gaps = 14/276 (5%) Query: 22 ATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELP 81 AT LA +++ + +G LG G FG+VY + +A+K + K ++ G + Sbjct: 1 ATALAEMPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEG-VE 59 Query: 82 NGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQE 141 + R E+ + + ++R+ ++F L+LE P +L+ + + G E Sbjct: 60 HQLR--REIEIQSHLRH--PNILRMYNYFHDRKRIYLMLEFA-PRGELYKELQKHGRFDE 114 Query: 142 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDF 201 + + +F ++ +A+ +CH V+HRDIK EN+L+ GELK+ DFG Sbjct: 115 QRSATFMEELADALHYCHERKVIHRDIKPENLLMGYK-GELKIADFGWSVHAPSLRRRTM 173 Query: 202 DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFF 255 GT Y PPE I + H +W G+L Y+ + G PF+ I+ + F Sbjct: 174 CGTLDYLPPEMIEG-KTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHTETHRRIVNVDLKF 232 Query: 256 RQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 +S + LI L P R + + HPW++ Sbjct: 233 PPFLSDGSKDLISKLLRYHPPQRLPLKGVMEHPWVK 268 >4TNB-A nrPDB Length = 590 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 81/325 (24%), Positives = 138/325 (42%), Gaps = 33/325 (10%) Query: 12 LRAAP----CNDLHATKLAPGK--EKEPLESQ-YQVGPLLGSGGFGSVYSGIRVSDNLPV 64 LR P + + + K E++P+ ++ +LG GGFG V + + Sbjct: 153 LRGEPFHEYLDSMFFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMY 212 Query: 65 AIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPE 124 A K +EK RI + E +L+KV+S F V+ L +E D+ L+L Sbjct: 213 ACKRLEKKRIKKR---KGESMALNEKQILEKVNSQF--VVNLAYAYETKDALCLVLTIMN 267 Query: 125 PVQDLFDFITERG--ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL 182 DL I G +EE A + ++L + H+ ++RD+K ENIL+D + G + Sbjct: 268 G-GDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHHENTVYRDLKPENILLD-DYGHI 325 Query: 183 KLIDFGSG-ALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIP 241 ++ D G + + + GT Y PE + RY G S W LG L+Y+M+ G P Sbjct: 326 RISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRY-GLSPDYWGLGCLIYEMIEGQSP 384 Query: 242 F----------EHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPT-----FEEIQN 286 F E D ++ + + + S E + + + L R E++ Sbjct: 385 FRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEEAAEVKR 444 Query: 287 HPWMQDVLLPQETAEIHLHSLSPGP 311 HP+ +++ + A + P P Sbjct: 445 HPFFRNMNFKRLEAGMLDPPFVPDP 469 >4EWQ-A nrPDB Length = 383 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 66/308 (21%), Positives = 125/308 (40%), Gaps = 54/308 (17%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +YQ +GSG +GSV + L VA+K + + + + + R E+ LLK Sbjct: 45 ERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP----FQSIIHAKRTYRELRLLKH 100 Query: 96 VSSGFSGVIRLLDWF------ERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 + VI LLD F E + L+ DL + + + L ++ + + Sbjct: 101 MKH--ENVIGLLDVFTPARSLEEFNDVYLVTHLMGA--DLNNIVKCQK-LTDDHVQFLIY 155 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSP 209 Q+L +++ H+ ++HRD+K N+ ++ + ELK++DFG D T + TR Y Sbjct: 156 QILRGLKYIHSADIIHRDLKPSNLAVNED-CELKILDFGLARH-TDDEMTGYVATRWYRA 213 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR----------QRV 259 PE + ++ ++ +WS+G ++ +++ G F + I + ++ R +++ Sbjct: 214 PEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 273 Query: 260 SSE---------------------------CQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 SSE L+ L L R T + H + Sbjct: 274 SSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQ 333 Query: 293 VLLPQETA 300 P + Sbjct: 334 YHDPDDEP 341 >5DYK-A nrPDB Length = 853 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 77/286 (26%), Positives = 137/286 (47%), Gaps = 23/286 (8%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 + + ++G G FG+V + A+K V K I + + N ++ E+ Sbjct: 539 DELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQ-QNNIKLEREITA--- 594 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 + +IRL+ F+ F + E +L+D I + G L + A+ + ++ A+ Sbjct: 595 -ENDHPFIIRLVRTFKDSKYFYFLTELVTG-GELYDAIRKLGLLSKSQAQFYLGSIILAI 652 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRY 215 + H +++RD+K ENIL+D +G +KLIDFG ++ YT GT Y PE I Sbjct: 653 EYLHERNIVYRDLKPENILLD-KQGYVKLIDFGCAKKVQGRAYT-LVGTPHYMAPEVILG 710 Query: 216 HRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE--------IIRGQVFFRQRVSS-ECQHL 266 + +G + +W+LGI LY+ +CG +PF +DEE I+ GQ+ F V+ + +L Sbjct: 711 -KGYGCTVDIWALGICLYEFICGPLPFGNDEEDQLEIFRDILTGQLTFPDYVTDTDSINL 769 Query: 267 IRWCLALRPSDRP-----TFEEIQNHPWMQDVLLPQETAEIHLHSL 307 ++ L P R F++I++HP+ + + + L Sbjct: 770 MKRLLCRLPQGRIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPL 815 >6AO5-A nrPDB Length = 362 Score = 238 bits (608), Expect = 2e-63, Method: Composition-based stats. Identities = 64/274 (23%), Positives = 112/274 (40%), Gaps = 27/274 (9%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVV 91 + E + V LG G +GSV+ I VAIK V + + + E+ Sbjct: 6 KQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVE--------SDLQEIIKEIS 57 Query: 92 LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT-ERGALQEELARSFFWQ 150 ++++ S + V++ + + +++E + D I L E+ + Sbjct: 58 IMQQCDSPY--VVKYYGSYFKNTDLWIVMEYC-GAGSVSDIIRLRNKTLIEDEIATILKS 114 Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYS 208 L+ + + H +HR+IK NIL++ G KL DFG L DT+ GT + Sbjct: 115 TLKGLEYLHFMRKIHRNIKAGNILLNTE-GHAKLADFGVAGQLTDTMAKRNTVIGTPFWM 173 Query: 209 PPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR---------- 258 PE I+ Y+ + +WSLGI +M G P+ D +R Sbjct: 174 APEVIQEIGYNCVA-DIWSLGITSIEMAEGKPPY-ADIHPMRAIFMIPTNPPPTFRKPEL 231 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 S + ++ CL P R T ++ HP++++ Sbjct: 232 WSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKN 265 >4QMW-A nrPDB Length = 310 Score = 237 bits (605), Expect = 4e-63, Method: Composition-based stats. Identities = 69/270 (25%), Positives = 114/270 (42%), Gaps = 22/270 (8%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 K E + +G G FG V+ GI VAIK ++ + D E E+ Sbjct: 24 KADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQ-----QEI 78 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQ 150 +L + S + V + + + +I+E L + E G L E + + Sbjct: 79 TVLSQCDSPY--VTKYYGSYLKDTKLWIIMEYLGGGSALD--LLEPGPLDETQIATILRE 134 Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYS 208 +L+ + + H+ +HRDIK N+L+ GE+KL DFG L DT F GT + Sbjct: 135 ILKGLDYLHSEKKIHRDIKAANVLLS-EHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWM 193 Query: 209 PPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ--------RVS 260 PE I+ Y ++ +WSLGI ++ G+ P + ++ + S Sbjct: 194 APEVIKQSAYDSKA-DIWSLGITAIELARGEPP-HSELHPMKVLFLIPKNNPPTLEGNYS 251 Query: 261 SECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 + + CL PS RPT +E+ H ++ Sbjct: 252 KPLKEFVEACLNKEPSFRPTAKELLKHKFI 281 >4J52-A nrPDB Length = 293 Score = 237 bits (605), Expect = 5e-63, Method: Composition-based stats. Identities = 67/280 (23%), Positives = 113/280 (40%), Gaps = 19/280 (6%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 LG GGF + A K V K + + ++ ME+ + + ++ V Sbjct: 22 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQ---REKMSMEISIHRSLAHQH--V 76 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGV 163 + +FE D ++LE + L + R AL E AR + Q++ ++ H V Sbjct: 77 VGFHGFFEDNDFVFVVLELCR-RRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRV 135 Query: 164 LHRDIKDENILIDLNRGELKLIDFGSGAL--LKDTVYTDFDGTRVYSPPEWIRYHRYHGR 221 +HRD+K N+ ++ + E+K+ DFG GT Y PE + + H Sbjct: 136 IHRDLKLGNLFLNEDL-EVKIGDFGLATKVEYDGERKKVLCGTPNYIAPEVLS-KKGHSF 193 Query: 222 SAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQHLIRWCLALRP 275 VWS+G ++Y ++ G PFE I + + + ++ LI+ L P Sbjct: 194 EVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDP 253 Query: 276 SDRPTFEEIQNHPWMQDVLLPQETAEIHL---HSLSPGPS 312 + RPT E+ N + +P L S PS Sbjct: 254 TARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPS 293 >4FZF-B nrPDB Length = 283 Score = 237 bits (604), Expect = 7e-63, Method: Composition-based stats. Identities = 66/266 (24%), Positives = 110/266 (41%), Gaps = 22/266 (8%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 E + +G G FG V+ GI VAIK ++ + D E E+ +L Sbjct: 7 EELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQ-----QEITVLS 61 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 + S + V + + + +I+E L + G E + ++L+ Sbjct: 62 QCDSSY--VTKYYGSYLKGSKLWIIMEYLGGGSALD--LLRAGPFDEFQIATMLKEILKG 117 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEW 212 + + H+ +HRDIK N+L+ +G++KL FG L DT F GT + PE Sbjct: 118 LDYLHSEKKIHRDIKAANVLLS-EQGDVKLAAFGVAGQLTDTQIKRNTFVGTPFWMAPEV 176 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSS--------ECQ 264 I+ Y ++ +WSLGI ++ G+ P D +R + + Sbjct: 177 IQQSAYDSKA-DIWSLGITAIELAKGEPP-NSDMHPMRVLFLIPKNNPPTLVGDFTKSFK 234 Query: 265 HLIRWCLALRPSDRPTFEEIQNHPWM 290 I CL PS RPT +E+ H ++ Sbjct: 235 EFIDACLNKDPSFRPTAKELLKHKFI 260 >5FET-A nrPDB Length = 847 Score = 236 bits (603), Expect = 9e-63, Method: Composition-based stats. Identities = 75/285 (26%), Positives = 135/285 (47%), Gaps = 23/285 (8%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 + + ++G G FG+V + A+K V K I + N ++ E+ Sbjct: 534 ELETERIIGRGTFGTVKLVHHKPTQIRYALKCVSKRSIISLNQ-QNNIKLEREITA---- 588 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156 + +IRL+ F+ + F + E +L+D I + G L + A+ + ++ A+ Sbjct: 589 ENDHPFIIRLVRTFKDSNCFYFLTELVTG-GELYDAIRKLGLLSKPQAQFYLGSIILAIE 647 Query: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYH 216 + H +++RD+K ENIL+D +G +KLIDFG ++ YT GT Y PE I Sbjct: 648 YLHERNIVYRDLKPENILLD-KQGYVKLIDFGCAKKIQGRAYT-LVGTPHYMAPEVILG- 704 Query: 217 RYHGRSAAVWSLGILLYDMVCGDIPFEHDEE--------IIRGQVFFRQRVSS-ECQHLI 267 + +G + +W+LG+ LY+ +CG +PF +D+E I+ GQ+ F VS + +L+ Sbjct: 705 KGYGCTVDIWALGVCLYEFICGPLPFGNDQEDQLEIFRDILTGQLTFPDYVSDQDSINLM 764 Query: 268 RWCLALRPSDRP-----TFEEIQNHPWMQDVLLPQETAEIHLHSL 307 + L P R F++I+ H + + + + L Sbjct: 765 KRLLCRLPQGRIGCSINGFKDIKEHAFFGNFNWDKLAGRLLEPPL 809 >2XIK-A nrPDB Length = 294 Score = 235 bits (601), Expect = 1e-62, Method: Composition-based stats. Identities = 72/296 (24%), Positives = 119/296 (40%), Gaps = 32/296 (10%) Query: 8 SLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIK 67 S+AHLR + E + +G G FG VY GI VAIK Sbjct: 1 SMAHLRGFANQH----------SRVDPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIK 50 Query: 68 HVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQ 127 ++ + D E E+ +L + S + + R + + +I+E Sbjct: 51 IIDLEEAEDEIEDIQ-----QEITVLSQCDSPY--ITRYFGSYLKSTKLWIIMEYLGGGS 103 Query: 128 DLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDF 187 L + + G L+E + ++L+ + + H+ +HRDIK N+L+ +G++KL DF Sbjct: 104 ALD--LLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLS-EQGDVKLADF 160 Query: 188 GSGALLKDTV--YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD 245 G L DT F GT + PE I+ + A +WSLGI ++ G+ P D Sbjct: 161 GVAGQLTDTQIKRNTFVGTPFWMAPEVIK-QSAYDFKADIWSLGITAIELAKGEPP-NSD 218 Query: 246 EEIIRGQVFFRQRVSS--------ECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 +R + + + CL P RPT +E+ H ++ Sbjct: 219 LHPMRVLFLIPKNSPPTLEGQHSKPFKEFVEACLNKDPRFRPTAKELLKHKFITRY 274 >4KRC-A nrPDB Length = 317 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 71/310 (22%), Positives = 124/310 (40%), Gaps = 58/310 (18%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 SQ++ LG+G + +VY G+ + + VA+K V+ D E + E+ L+K Sbjct: 4 SSQFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKLD-----SEEGTPSTAIREISLMK 58 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER------GALQEELARSFF 148 ++ ++RL D + L+ E + DL ++ R L+ L + F Sbjct: 59 ELKH--ENIVRLYDVIHTENKLTLVFEFMDN--DLKKYMDSRTVGNTPRGLELNLVKYFQ 114 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT--DFDGTRV 206 WQ+L+ + CH +LHRD+K +N+LI+ RG+LKL DFG V T T Sbjct: 115 WQLLQGLAFCHENKILHRDLKPQNLLIN-KRGQLKLGDFGLARAFGIPVNTFSSEVVTLW 173 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF----------- 255 Y P+ + R + S +WS G +L +M+ G F + + ++ F Sbjct: 174 YRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDEEQLKLIFDIMGTPNESLW 233 Query: 256 -----------------------------RQRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 ++ + + L L P R + ++ + Sbjct: 234 PSVTKLPKYNPNIQQRPPRDLRQVLQPHTKEPLDGNLMDFLHGLLQLNPDMRLSAKQALH 293 Query: 287 HPWMQDVLLP 296 HPW + Sbjct: 294 HPWFAEYYHH 303 >3C51-A nrPDB Length = 543 Score = 235 bits (600), Expect = 2e-62, Method: Composition-based stats. Identities = 77/330 (23%), Positives = 131/330 (39%), Gaps = 36/330 (10%) Query: 9 LAHLRAAP----CNDLHATKLAPGK--EKEPL-ESQYQVGPLLGSGGFGSVYSGIRVSDN 61 LAHL AP + L+ + K E +P+ E + +LG GGFG V++ + Sbjct: 151 LAHLGQAPFQEFLDSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGRGGFGEVFACQMKATG 210 Query: 62 LPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILE 121 A +K + +E +L KV S F ++ L FE L++ Sbjct: 211 KLYA---CKKLNKKRLKKRKGYQGAMVEKKILAKVHSRF--IVSLAYAFETKTDLCLVMT 265 Query: 122 RPEPVQDLFDFI----TERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDL 177 D+ I + QE A + Q++ + H H +++RD+K EN+L+D Sbjct: 266 IMNG-GDIRYHIYNVDEDNPGFQEPRAIFYTAQIVSGLEHLHQRNIIYRDLKPENVLLD- 323 Query: 178 NRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDM 235 + G +++ D G LK T + GT + PE + Y S ++LG+ LY+M Sbjct: 324 DDGNVRISDLGLAVELKAGQTKTKGYAGTPGFMAPELLLGEEY-DFSVDYFALGVTLYEM 382 Query: 236 VCGDIPF----------EHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEE-- 283 + PF E + ++ V + + S + L P R F + Sbjct: 383 IAARGPFRARGEKVENKELKQRVLEQAVTYPDKFSPASKDFCEALLQKDPEKRLGFRDGS 442 Query: 284 ---IQNHPWMQDVLLPQETAEIHLHSLSPG 310 ++ HP +D+ Q A + P Sbjct: 443 CDGLRTHPLFRDISWRQLEAGMLTPPFVPD 472 >4AGU-A nrPDB Length = 311 Score = 234 bits (597), Expect = 4e-62, Method: Composition-based stats. Identities = 69/312 (22%), Positives = 124/312 (39%), Gaps = 47/312 (15%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 + +Y+ +G G +G V+ VAIK + + E+ +L Sbjct: 1 MMEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKF----LESEDDPVIKKIALREIRML 56 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 K++ ++ LL+ F R L+ E + L + + + E L +S WQ L+ Sbjct: 57 KQLKH--PNLVNLLEVFRRKRRLHLVFEYCDHTV-LHELDRYQRGVPEHLVKSITWQTLQ 113 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD--TVYTDFDGTRVYSPPE 211 AV CH +HRD+K ENILI +KL DFG LL Y D TR Y PE Sbjct: 114 AVNFCHKHNCIHRDVKPENILIT-KHSVIKLCDFGFARLLTGPSDYYDDEVATRWYRSPE 172 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR--------------- 256 + +G VW++G + +++ G + ++ + + + Sbjct: 173 LLVGDTQYGPPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFST 232 Query: 257 ----------------------QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVL 294 +S L++ CL + P++R T E++ +HP+ +++ Sbjct: 233 NQYFSGVKIPDPEDMEPLELKFPNISYPALGLLKGCLHMDPTERLTCEQLLHHPYFENIR 292 Query: 295 LPQETAEIHLHS 306 ++ A+ H Sbjct: 293 EIEDLAKEHDKP 304 >5D7A-A nrPDB Length = 308 Score = 234 bits (597), Expect = 4e-62, Method: Composition-based stats. Identities = 75/278 (26%), Positives = 115/278 (41%), Gaps = 34/278 (12%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 +++ L+G+G +G VY G V AIK ++ + E+ +LKK S Sbjct: 19 FELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTG-------DEEEEIKQEINMLKKYS 71 Query: 98 SGFSGVIRLLDWFERP------DSFVLILERPEPVQDLFDFITERG--ALQEELARSFFW 149 + F + D L++E + D I L+EE Sbjct: 72 H-HRNIATYYGAFIKKNPPGMDDQLWLVMEFC-GAGSVTDLIKNTKGNTLKEEWIAYICR 129 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVY 207 ++L + H H V+HRDIK +N+L+ N E+KL+DFG A L TV F GT + Sbjct: 130 EILRGLSHLHQHKVIHRDIKGQNVLLTEN-AEVKLVDFGVSAQLDRTVGRRNTFIGTPYW 188 Query: 208 SPPEWIRYHRY----HGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR------- 256 PE I + + +WSLGI +M G P D +R Sbjct: 189 MAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPL-CDMHPMRALFLIPRNPAPRL 247 Query: 257 --QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 ++ S + Q I CL S RP E++ HP+++D Sbjct: 248 KSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRD 285 >3A8W-A nrPDB Length = 345 Score = 234 bits (597), Expect = 5e-62, Method: Composition-based stats. Identities = 68/296 (22%), Positives = 131/296 (44%), Gaps = 30/296 (10%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 + + ++G G + V + A+K V+K+ ++D ++ V E + ++ Sbjct: 10 DFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKELVNDDEDIDW---VQTEKHVFEQ- 65 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156 +S ++ L F+ ++E DL + + L EE AR + ++ A+ Sbjct: 66 ASNHPFLVGLHSCFQTESRLFFVIEYVNG-GDLMFHMQRQRKLPEEHARFYSAEISLALN 124 Query: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA--LLKDTVYTDFDGTRVYSPPEWIR 214 + H G+++RD+K +N+L+D G +KL D+G L + F GT Y PE +R Sbjct: 125 YLHERGIIYRDLKLDNVLLDSE-GHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILR 183 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPFE-------HDEE--------IIRGQVFFRQRV 259 Y G S W+LG+L+++M+ G PF+ D+ I+ Q+ + + Sbjct: 184 GEDY-GFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPRSL 242 Query: 260 SSECQHLIRWCLALRPSDRP------TFEEIQNHPWMQDVLLPQETAEIHLHSLSP 309 S + +++ L P +R F +IQ HP+ ++V + + P Sbjct: 243 SVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKP 298 >4JG6-A nrPDB Length = 355 Score = 234 bits (596), Expect = 6e-62, Method: Composition-based stats. Identities = 62/275 (22%), Positives = 110/275 (40%), Gaps = 31/275 (11%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 Y+V +G G + I + N+ A+K ++K + E+ +L Sbjct: 33 FTDGYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTE----------EIEIL 82 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 + +I L D ++ ++ E + +L D I + E A + + + + Sbjct: 83 LRYG-QHPNIITLKDVYDDGKYVYVVTELMKG-GELLDKILRQKFFSEREASAVLFTITK 140 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRGE---LKLIDFGSGALLK--DTVYTDFDGTRVYS 208 V + H GV+HRD+K NIL G +++ DFG L+ + + T + Sbjct: 141 TVEYLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFV 200 Query: 209 PPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR------------ 256 PE + Y + +WSLG+LLY M+ G PF + + ++ R Sbjct: 201 APEVLERQGY-DAACDIWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGY 259 Query: 257 -QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 VS + L+ L + P R T + HPW+ Sbjct: 260 WNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 294 >3NIZ-A nrPDB Length = 311 Score = 234 bits (596), Expect = 6e-62, Method: Composition-based stats. Identities = 75/303 (24%), Positives = 124/303 (40%), Gaps = 49/303 (16%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVV 91 + L +YQ +G G +G VY VA+K + D + + E+ Sbjct: 17 QGLMEKYQKLEKVGEGTYGVVYKAKDSQ-GRIVALKRIRLDA----EDEGIPSTAIREIS 71 Query: 92 LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA-LQEELARSFFWQ 150 LLK++ ++ L+D L+ E E DL + E LQ+ + + +Q Sbjct: 72 LLKELHH--PNIVSLIDVIHSERCLTLVFEFMEK--DLKKVLDENKTGLQDSQIKIYLYQ 127 Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYS 208 +L V HCH +LHRD+K +N+LI+ + G LKL DFG V YT T Y Sbjct: 128 LLRGVAHCHQHRILHRDLKPQNLLINSD-GALKLADFGLARAFGIPVRSYTHEVVTLWYR 186 Query: 209 PPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH---DEEIIRG-------------- 251 P+ + + + S +WS+G + +M+ G F D+++ + Sbjct: 187 APDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQ 246 Query: 252 ------------QVFFRQRVSS-------ECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 QVF ++ SS E L+ L P+ R + + NHP+ +D Sbjct: 247 VQELPLWKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKD 306 Query: 293 VLL 295 + Sbjct: 307 LDP 309 >3ORZ-A nrPDB Length = 316 Score = 233 bits (595), Expect = 7e-62, Method: Composition-based stats. Identities = 68/274 (24%), Positives = 131/274 (47%), Gaps = 24/274 (8%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 ++ G +LG G F +V ++ + AIK +EK I ++P TR E ++ + Sbjct: 37 EDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTR---ERDVMSR 93 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 + F ++L F+ + L + +L +I + G+ E R + +++ A+ Sbjct: 94 LDHPF--FVKLYFCFQDDEKLYFGLSYAKN-GELLKYIRKIGSFDETCTRFYTAEIVSAL 150 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL----KDTVYTDFDGTRVYSPPE 211 + H G++HRD+K ENIL++ + +++ DFG+ +L K F GT Y PE Sbjct: 151 EYLHGKGIIHRDLKPENILLNEDM-HIQITDFGTAKVLSPESKQARANSFVGTAQYVSPE 209 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQRVSSECQH 265 + + +S+ +W+LG ++Y +V G PF ++II+ + F ++ + + Sbjct: 210 LL-TEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYDFPEKFFPKARD 268 Query: 266 LIRWCLALRPSDRPTFEE------IQNHPWMQDV 293 L+ L L + R EE ++ HP+ + V Sbjct: 269 LVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESV 302 >3FXW-A nrPDB Length = 336 Score = 233 bits (595), Expect = 7e-62, Method: Composition-based stats. Identities = 79/294 (26%), Positives = 121/294 (41%), Gaps = 36/294 (12%) Query: 27 PGKEKEPLESQYQVGP-LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTR 85 P +K + YQ+ +LG G G V A+K + + + Sbjct: 19 PEPKKYAVTDDYQLSKQVLGLGVNGKVLECFHRRTGQKCALKLL-----------YDSPK 67 Query: 86 VPMEVVLLKKVSSGFSGVIRLLDWFE---RPDSFVLILERPEPVQDLFDFITERG--ALQ 140 EV + S G ++ +LD +E +LI+ +LF I ERG A Sbjct: 68 ARQEVDHHWQASGG-PHIVCILDVYENMHHGKRCLLIIMECMEGGELFSRIQERGDQAFT 126 Query: 141 EELARSFFWQVLEAVRHCHNCGVLHRDIKDENILID--LNRGELKLIDFGSGALLKDTVY 198 E A + A++ H+ + HRD+K EN+L LKL DFG Sbjct: 127 EREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLLYTSKEKDAVLKLTDFGFAKETTQNAL 186 Query: 199 TDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE----------EI 248 T Y PE + +Y +S +WSLG+++Y ++CG PF + I Sbjct: 187 QTPCYTPYYVAPEVLGPEKY-DKSCDMWSLGVIMYILLCGFPPFYSNTGQAISPGMKRRI 245 Query: 249 IRGQVFFRQR----VSSECQHLIRWCLALRPSDRPTFEEIQNHPWM-QDVLLPQ 297 GQ F VS + + LIR L P++R T + NHPW+ Q +++PQ Sbjct: 246 RLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPTERLTITQFMNHPWINQSMVVPQ 299 >6FDY-U nrPDB Length = 276 Score = 233 bits (595), Expect = 7e-62, Method: Composition-based stats. Identities = 76/271 (28%), Positives = 129/271 (47%), Gaps = 20/271 (7%) Query: 38 YQVGPLLGSGGFGSVYSGI-RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 + + LGSG + +VY + VAIK V K ++ + + E+ +LK + Sbjct: 13 FILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNK----ASVENLLTEIEILKGI 68 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156 +++L D+ D+ LI+E DL FI R L E++AR F Q+ A++ Sbjct: 69 RH--PHIVQLKDFQWDSDNIYLIMEFCAG-GDLSRFIHTRRILPEKVARVFMQQLASALQ 125 Query: 157 HCHNCGVLHRDIKDENILIDL-NRGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPEWIR 214 H + H D+K +NIL+ + LKL DFG + G+ +Y PE + Sbjct: 126 FLHERNISHLDLKPQNILLSSLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVC 185 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPF------EHDEEIIRG---QVFFRQRVSSECQH 265 +Y R +WS+G++LY+ + G PF E +E+I ++ R +S +C+ Sbjct: 186 QRQYDAR-VDLWSMGVILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRD 244 Query: 266 LIRWCLALRPSDRPTFEEIQNHPWMQDVLLP 296 L++ L PS R +F++ HPW+ +P Sbjct: 245 LLQRLLERDPSRRISFQDFFAHPWVDLEHMP 275 >2X4F-A nrPDB Length = 373 Score = 233 bits (595), Expect = 8e-62, Method: Composition-based stats. Identities = 78/286 (27%), Positives = 129/286 (45%), Gaps = 25/286 (8%) Query: 30 EKEPLESQYQVGPL--LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 ++ + S Y V LG G FG V+ + L +A K ++ + D E+ N Sbjct: 81 KQGAVNSFYTVSKTEILGGGRFGQVHKCEETATGLKLAAKIIKTRGMKDKEEVKN----- 135 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA-LQEELARS 146 E+ ++ ++ +I+L D FE + VL++E + +LFD I + L E Sbjct: 136 -EISVMNQLDHA--NLIQLYDAFESKNDIVLVMEYVDG-GELFDRIIDESYNLTELDTIL 191 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENIL-IDLNRGELKLIDFGSGALLK-DTVYTDFDGT 204 F Q+ E +RH H +LH D+K ENIL ++ + ++K+IDFG K GT Sbjct: 192 FMKQICEGIRHMHQMYILHLDLKPENILCVNRDAKQIKIIDFGLARRYKPREKLKVNFGT 251 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHDEEIIRGQVFFR------ 256 + PE + Y + +WS+G++ Y ++ G PF ++D E + + R Sbjct: 252 PEFLAPEVVNYD-FVSFPTDMWSVGVIAYMLLSGLSPFLGDNDAETLNNILACRWDLEDE 310 Query: 257 --QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA 300 Q +S E + I L S R + E HPW+ D L + Sbjct: 311 EFQDISEEAKEFISKLLIKEKSWRISASEALKHPWLSDHKLHSRLS 356 >6CMJ-A nrPDB Length = 321 Score = 233 bits (594), Expect = 9e-62, Method: Composition-based stats. Identities = 68/274 (24%), Positives = 123/274 (44%), Gaps = 24/274 (8%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISD-----WGELPNGTRVPMEV 90 QY + +G G +G V +DN A+K + K ++ +V E+ Sbjct: 34 DQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGGCIQPRGPIEQVYQEI 93 Query: 91 VLLKKVSSGFSGVIRLLDWFERP--DSFVLILERPEPVQDLFDFITERGALQEELARSFF 148 +LKK+ V++L++ + P D ++ E + + L E+ AR +F Sbjct: 94 AILKKLDH--PNVVKLVEVLDDPNEDHLYMVFELVNQGPVME--VPTLKPLSEDQARFYF 149 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRV 206 +++ + + H ++HRDIK N+L+ + G +K+ DFG K D + ++ GT Sbjct: 150 QDLIKGIEYLHYQKIIHRDIKPSNLLVGED-GHIKIADFGVSNEFKGSDALLSNTVGTPA 208 Query: 207 YSPPEWIRYHR--YHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFR-- 256 + PE + R + G++ VW++G+ LY V G PF + +I + F Sbjct: 209 FMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQ 268 Query: 257 QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 ++ + + LI L P R EI+ HPW+ Sbjct: 269 PDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 302 >3KN6-A nrPDB Length = 325 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 73/287 (25%), Positives = 121/287 (42%), Gaps = 36/287 (12%) Query: 30 EKEPLESQYQVG---PLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRV 86 + P Y + LG G F + N A+K + K Sbjct: 2 KDSPFYQHYDLDLKDKPLGEGSFSICRKCVHKKSNQAFAVKIISKR---------MEANT 52 Query: 87 PMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARS 146 E+ LK + G +++L + F L++E +LF+ I ++ E A Sbjct: 53 QKEITALK-LCEGHPNIVKLHEVFHDQLHTFLVMELLNG-GELFERIKKKKHFSETEASY 110 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG--ELKLIDFGSGAL--LKDTVYTDFD 202 +++ AV H H+ GV+HRD+K EN+L E+K+IDFG L + Sbjct: 111 IMRKLVSAVSHMHDVGVVHRDLKPENLLFTDENDNLEIKIIDFGFARLKPPDNQPLKTPC 170 Query: 203 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE-------------EII 249 T Y+ PE + + Y S +WSLG++LY M+ G +PF+ + +I Sbjct: 171 FTLHYAAPELLNQNGY-DESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSAVEIMKKIK 229 Query: 250 RGQVFFR----QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 +G F + VS E + LI+ L + P+ R ++ + W+QD Sbjct: 230 KGDFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQD 276 >4AF3-A nrPDB Length = 292 Score = 232 bits (593), Expect = 1e-61, Method: Composition-based stats. Identities = 75/268 (27%), Positives = 124/268 (46%), Gaps = 14/268 (5%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 89 + +++G LG G FG+VY + VA+K + K +I G + + R E Sbjct: 17 TRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEG-VEHQLR--RE 73 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 + + + ++RL ++F LILE P +L+ + + E+ + Sbjct: 74 IEIQAHLHH--PNILRLYNYFYDRRRIYLILEYA-PRGELYKELQKSCTFDEQRTATIME 130 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSP 209 ++ +A+ +CH V+HRDIK EN L+ +GELK+ DFG GT Y P Sbjct: 131 ELADALMYCHGKKVIHRDIKPEN-LLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLP 189 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRVSSEC 263 PE I R H +W +G+L Y+++ G+ PFE I++ + F V + Sbjct: 190 PEMIEG-RMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPTGA 248 Query: 264 QHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 Q LI L PS+R ++ HPW++ Sbjct: 249 QDLISKLLRHNPSERLPLAQVSAHPWVR 276 >3OHT-A nrPDB Length = 389 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 70/316 (22%), Positives = 124/316 (39%), Gaps = 54/316 (17%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +YQ +GSG +GSV S V L +A+K + + + + + R E+ LLK Sbjct: 51 ERYQTLSPVGSGAYGSVCSSYDVKSGLKIAVKKLSRP----FQSIIHAKRTYRELRLLKH 106 Query: 96 VSSGFSGVIRLLDWF------ERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 + VI LLD F E + L+ DL + + + L ++ + + Sbjct: 107 MKH--ENVIGLLDVFTPATSLEEFNDVYLVTHLMGA--DLNNIVKCQK-LTDDHVQFLIY 161 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSP 209 Q+L +++ H+ ++HRD+K N+ ++ + ELK++DFG D T + TR Y Sbjct: 162 QILRGLKYIHSADIIHRDLKPSNLAVNED-CELKILDFGLARH-TDDEMTGYVATRWYRA 219 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR----------QRV 259 PE + ++ + +WS+G ++ +++ G F + I + Q R R+ Sbjct: 220 PEIMLNWMHYNMTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIMRLTGTPPASVISRM 279 Query: 260 S---------------------------SECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 L+ L L R T E HP+ Sbjct: 280 PSHEARNYINSLPQMPKRNFADVFIGANPLAVDLLEKMLVLDTDKRITASEALAHPYFSQ 339 Query: 293 VLLPQETAEIHLHSLS 308 P + E + S Sbjct: 340 YHDPDDEPESEPYDQS 355 >4YHJ-A nrPDB Length = 584 Score = 231 bits (590), Expect = 3e-61, Method: Composition-based stats. Identities = 77/336 (22%), Positives = 132/336 (39%), Gaps = 35/336 (10%) Query: 3 LSKINSLAH--LRAAPCNDLHATKL------APGKEKEPLESQ-YQVGPLLGSGGFGSVY 53 + +AH LR P + + E++P+ ++ +LG GGFG V Sbjct: 143 FEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQPVTKNTFRHYRVLGKGGFGEVC 202 Query: 54 SGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERP 113 + + A +K + + E +L+KV S F V+ L +E Sbjct: 203 ACQVRATGKMYA---CKKLQKKRIKKRKGEAMALNEKRILEKVQSRF--VVSLAYAYETK 257 Query: 114 DSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDE 171 D+ L+L DL I G E+ A + ++ + +++RD+K E Sbjct: 258 DALCLVLTIMNG-GDLKFHIYNLGNPGFDEQRAVFYAAELCCGLEDLQRERIVYRDLKPE 316 Query: 172 NILIDLNRGELKLIDFGSGALLKDTVYTD-FDGTRVYSPPEWIRYHRYHGRSAAVWSLGI 230 NIL+D +RG +++ D G + + GT Y PE + +Y S W LG Sbjct: 317 NILLD-DRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNNEKY-TFSPDWWGLGC 374 Query: 231 LLYDMVCGDIPF----------EHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRP- 279 L+Y+M+ G PF E D+ I + ++ S + + + R L PS R Sbjct: 375 LIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSICRMLLTKNPSKRLG 434 Query: 280 ----TFEEIQNHPWMQDVLLPQETAEIHLHSLSPGP 311 ++ HP +D+ + A + P P Sbjct: 435 CRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDP 470 >1G3N-A nrPDB Length = 326 Score = 230 bits (588), Expect = 5e-61, Method: Composition-based stats. Identities = 69/315 (21%), Positives = 121/315 (38%), Gaps = 51/315 (16%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIR-VSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 + QY+ +G G +G V+ + VA+K V GE EV +L Sbjct: 10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVR----VQTGEEGMPLSTIREVAVL 65 Query: 94 KKVSS-GFSGVIRLLDWF-----ERPDSFVLILERPEPVQDLFDFITE--RGALQEELAR 145 + + + V+RL D +R L+ E + QDL ++ + + E + Sbjct: 66 RHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVD--QDLTTYLDKVPEPGVPTETIK 123 Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGT 204 +Q+L + H+ V+HRD+K +NIL+ + G++KL DFG + T T Sbjct: 124 DMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSS-GQIKLADFGLARIYSFQMALTSVVVT 182 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIR-----------GQV 253 Y PE + Y +WS+G + +M F ++ + G+ Sbjct: 183 LWYRAPEVLLQSSYATP-VDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEE 241 Query: 254 FFRQRV--------SSEC--------------QHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 + + V S + L+ CL P+ R + +HP+ Q Sbjct: 242 DWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQ 301 Query: 292 DVLLPQETAEIHLHS 306 D+ +E + HL Sbjct: 302 DLERCKENLDSHLPP 316 >3DLS-A nrPDB Length = 335 Score = 230 bits (587), Expect = 5e-61, Method: Composition-based stats. Identities = 89/263 (33%), Positives = 134/263 (50%), Gaps = 6/263 (2%) Query: 33 PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISD--WGELPNGTRVPMEV 90 +Y LGSG FG V++ + N V +K ++K+++ + W E P +V +E+ Sbjct: 21 EYSQKYSTMSPLGSGAFGFVWTAVDKEKNKEVVVKFIKKEKVLEDCWIEDPKLGKVTLEI 80 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQ 150 +L +V +I++LD FE F L++E+ DLF FI L E LA F Q Sbjct: 81 AILSRVEHA--NIIKVLDIFENQGFFQLVMEKHGSGLDLFAFIDRHPRLDEPLASYIFRQ 138 Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL-KDTVYTDFDGTRVYSP 209 ++ AV + ++HRDIKDENI+I + +KLIDFGS A L + ++ F GT Y Sbjct: 139 LVSAVGYLRLKDIIHRDIKDENIVIAEDF-TIKLIDFGSAAYLERGKLFYTFCGTIEYCA 197 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRW 269 PE + + Y G +WSLG+ LY +V + PF EE + + VS E L+ Sbjct: 198 PEVLMGNPYRGPELEMWSLGVTLYTLVFEENPFCELEETVEAAIHPPYLVSKELMSLVSG 257 Query: 270 CLALRPSDRPTFEEIQNHPWMQD 292 L P R T E++ PW+ Sbjct: 258 LLQPVPERRTTLEKLVTDPWVTQ 280 >6E9W-A nrPDB Length = 443 Score = 230 bits (587), Expect = 5e-61, Method: Composition-based stats. Identities = 76/327 (23%), Positives = 139/327 (42%), Gaps = 33/327 (10%) Query: 3 LSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNL 62 L K ++ + + + ++ ++ Y+V ++G G FG V S Sbjct: 74 LRKNKNIDNFLSRYKDTINKI-----RDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRK 128 Query: 63 PVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILER 122 A+K + K + + E ++ +S + V++L F+ +++E Sbjct: 129 VYAMKLLSKFEMIKRSDSAF---FWEERDIMAFANSPW--VVQLFYAFQDDRYLYMVMEY 183 Query: 123 PEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL 182 P DL + ++ + E+ AR + +V+ A+ H+ G +HRD+K +N+L+D + G L Sbjct: 184 M-PGGDLVNLMSNYD-VPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKS-GHL 240 Query: 183 KLIDFGSGALLKDTVYT---DFDGTRVYSPPEWIR---YHRYHGRSAAVWSLGILLYDMV 236 KL DFG+ + GT Y PE ++ Y+GR WS+G+ LY+M+ Sbjct: 241 KLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEML 300 Query: 237 CGDIPFEHDEEII--------RGQVFFRQ--RVSSECQHLIRWCLALRPSDRP---TFEE 283 GD PF D + + + F +S E ++LI L R EE Sbjct: 301 VGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLT-DREVRLGRNGVEE 359 Query: 284 IQNHPWMQDVLLPQETAEIHLHSLSPG 310 I+ H + ++ ET + + P Sbjct: 360 IKRHLFFKNDQWAWETLRDTVAPVVPD 386 >5J5T-A nrPDB Length = 370 Score = 230 bits (587), Expect = 5e-61, Method: Composition-based stats. Identities = 67/292 (22%), Positives = 117/292 (40%), Gaps = 27/292 (9%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 + +++ +GSG +G VY V+ AIK ++ + D+ V E++++K Sbjct: 3 QEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAV------VQQEIIMMK 56 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 ++ + R D + +E L D G L E + L+ Sbjct: 57 DCKH--PNIVAYFGSYLRRDKLWICMEFCGG-GSLQDIYHVTGPLSELQIAYVSRETLQG 113 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEW 212 + + H+ G +HRDIK NIL+ + G +KL DFG A + T+ F GT + PE Sbjct: 114 LYYLHSKGKMHRDIKGANILLT-DNGHVKLADFGVSAQITATIAKRKAFIGTPYWMAPEV 172 Query: 213 IRYHRYHGRS--AAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF------------RQR 258 R G + +W++GI ++ P D +R + + Sbjct: 173 AAVERKGGYNQLCDLWAVGITAIELAELQPP-MFDLHPMRALFLMTKSNFQPPKLKDKMK 231 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPG 310 S+ H ++ L P RPT E++ HP++ L E+ +P Sbjct: 232 WSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPD 283 >5LOH-A nrPDB Length = 341 Score = 230 bits (586), Expect = 9e-61, Method: Composition-based stats. Identities = 69/299 (23%), Positives = 127/299 (42%), Gaps = 29/299 (9%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 89 K P ++ + + G FG VY G A+K V+K + + + + + + Sbjct: 30 PKPPSIEEFSIVKPISRGAFGKVYLGQ--KGGKLYAVKVVKKADMIN-KNMTHQVQAERD 86 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 + L K ++ L + ++ L++E D+ + G EE+A + Sbjct: 87 ALALSK----SPFIVHLYYSLQSANNVYLVMEYLIG-GDVKSLLHIYGYFDEEMAVKYIS 141 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA--------LLKDTVYTDF 201 +V A+ + H G++HRD+K +N+LI N G +KL DFG ++ F Sbjct: 142 EVALALDYLHRHGIIHRDLKPDNMLIS-NEGHIKLTDFGLSKVTLNRDINMMDILTTRTF 200 Query: 202 DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFF 255 GT Y PE + R HG + W+LG+ L++ + G PF + + I++ + + Sbjct: 201 CGTPDYLAPELLLG-RAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPW 259 Query: 256 R---QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGP 311 +++S Q + L + + R +E++ HP DV E + P P Sbjct: 260 PEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVDW--ENLQHQTMPFIPQP 316 >2F9G-A nrPDB Length = 353 Score = 229 bits (585), Expect = 9e-61, Method: Composition-based stats. Identities = 75/333 (22%), Positives = 125/333 (37%), Gaps = 71/333 (21%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 + S +Q+ LLG G +G V S VAIK +E + + R E+ +L Sbjct: 9 ISSDFQLKSLLGEGAYGVVCSATHKPTGEIVAIKKIEP-----FDKPLFALRTLREIKIL 63 Query: 94 KKVSSGFSGVIRLL-----DWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 148 K +I + D FE + +I E + + L ++ + F Sbjct: 64 KHFKH--ENIITIFNIQRPDSFENFNEVYIIQELMQTD---LHRVISTQMLSDDHIQYFI 118 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV----------- 197 +Q L AV+ H V+HRD+K N+LI+ N +LK+ DFG ++ ++ Sbjct: 119 YQTLRAVKVLHGSNVIHRDLKPSNLLINSN-CDLKVCDFGLARIIDESAADNSEPTGQQS 177 Query: 198 -YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE---------- 246 T++ TR Y PE + + R+ VWS G +L ++ F + Sbjct: 178 GMTEYVATRWYRAPEVMLTSAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFG 237 Query: 247 --------------------EIIRGQVFFR--------QRVSSECQHLIRWCLALRPSDR 278 E I+ + RV+ + L++ L P+ R Sbjct: 238 IIGTPHSDNDLRCIESPRAREYIKSLPMYPAAPLEKMFPRVNPKGIDLLQRMLVFDPAKR 297 Query: 279 PTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGP 311 T +E HP++Q P + E P P Sbjct: 298 ITAKEALEHPYLQTYHDPNDEPE-----GEPIP 325 >6BDL-A nrPDB Length = 347 Score = 229 bits (585), Expect = 9e-61, Method: Composition-based stats. Identities = 78/289 (26%), Positives = 136/289 (47%), Gaps = 23/289 (7%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDN-LPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 S + + LG GGFG V S+ A+K ++K I D + + + E +++ Sbjct: 34 SDFNIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEH---IRSEKQIMQ 90 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 S F ++RL F+ +++E +L+ + +RG+ ++ R + V+EA Sbjct: 91 GAHSDF--IVRLYRTFKDSKYLYMLMEACLG-GELWTILRDRGSFEDSTTRFYTACVVEA 147 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT-DFDGTRVYSPPEWI 213 + H+ G+++RD+K EN+++D RG KL+DFG + T F GT Y PE I Sbjct: 148 FAYLHSKGIIYRDLKPENLILDH-RGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEII 206 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRG--QVFFRQRVSSECQH 265 ++ H SA WSLGIL+Y+++ G PF + I+RG + F ++++ + Sbjct: 207 L-NKGHDISADYWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAAN 265 Query: 266 LIRWCLALRPSDRP-----TFEEIQNHPWMQDVLLPQETAEIHLHSLSP 309 LI+ PS+R ++IQ H W + + P Sbjct: 266 LIKKLCRDNPSERLGNLKNGVKDIQKHKWFEGFNWEGLRKGTLTPPIIP 314 >3Q53-A nrPDB Length = 306 Score = 229 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 61/269 (22%), Positives = 127/269 (47%), Gaps = 25/269 (9%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 + +Y +G G G+VY+ + V+ VAI+ + + P + E+++++ Sbjct: 20 KKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMN------LQQQPKKELIINEILVMR 73 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 + + ++ LD + D +++E L D +TE + E + + L+A Sbjct: 74 ENKN--PNIVNYLDSYLVGDELWVVMEYLAG-GSLTDVVTETC-MDEGQIAAVCRECLQA 129 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYTDFDGTRVYSPPEW 212 + H+ V+HRDIK +NIL+ ++ G +KL DFG A + + + + GT + PE Sbjct: 130 LEFLHSNQVIHRDIKSDNILLGMD-GSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEV 188 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF----------RQRVSSE 262 + + +G +WSLGI+ +M+ G+ P+ +E +R +++S+ Sbjct: 189 V-TRKAYGPKVDIWSLGIMAIEMIEGEPPY-LNENPLRALYLIATNGTPELQNPEKLSAI 246 Query: 263 CQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 + + CL + R + +E+ H +++ Sbjct: 247 FRDFLNRCLEMDVEKRGSAKELIQHQFLK 275 >3DAK-A nrPDB Length = 290 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 62/294 (21%), Positives = 112/294 (38%), Gaps = 40/294 (13%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 89 Y++ ++GSG V + VAIK + ++ + + E Sbjct: 4 PWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMD-----ELLKE 58 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT--------ERGALQE 141 + + + ++ F D L+++ + D I + G L E Sbjct: 59 IQAMSQCHH--PNIVSYYTSFVVKDELWLVMKLLSG-GSVLDIIKHIVAKGEHKSGVLDE 115 Query: 142 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL-------K 194 + +VLE + + H G +HRD+K NIL+ + G +++ DFG A L + Sbjct: 116 STIATILREVLEGLEYLHKNGQIHRDVKAGNILLGED-GSVQIADFGVSAFLATGGDITR 174 Query: 195 DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF------------ 242 + V F GT + PE + R + A +WS GI ++ G P+ Sbjct: 175 NKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLT 234 Query: 243 -EHDEEIIRGQVFFR---QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 ++D + V + ++ + +I CL P RPT E+ H + Q Sbjct: 235 LQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQK 288 >5YV8-A nrPDB Length = 298 Score = 229 bits (584), Expect = 1e-60, Method: Composition-based stats. Identities = 69/289 (23%), Positives = 125/289 (43%), Gaps = 39/289 (13%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNG------------ 83 +QY + +G G +G V +DN A+K + K ++ P Sbjct: 13 NQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGG 72 Query: 84 --------TRVPMEVVLLKKVSSGFSGVIRLLDWFERP--DSFVLILERPEPVQDLFDFI 133 +V E+ +LKK+ V++L++ + P D ++ E + + Sbjct: 73 CIQPRGPIEQVYQEIAILKKLDH--PNVVKLVEVLDDPNEDHLYMVFELVNQGPVME--V 128 Query: 134 TERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL 193 L E+ AR +F +++ + + H ++HRDIK N+L+ + G +K+ DFG Sbjct: 129 PTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGED-GHIKIADFGVSNEF 187 Query: 194 K--DTVYTDFDGTRVYSPPEWIRYHR--YHGRSAAVWSLGILLYDMVCGDIPFEHD---- 245 K D + ++ GT + PE + R + G++ VW++G+ LY V G PF + Sbjct: 188 KGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMC 247 Query: 246 --EEIIRGQVFFR--QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 +I + F ++ + + LI L P R EI+ HPW+ Sbjct: 248 LHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWV 296 >4AU8-A nrPDB Length = 296 Score = 228 bits (583), Expect = 2e-60, Method: Composition-based stats. Identities = 73/301 (24%), Positives = 124/301 (41%), Gaps = 48/301 (15%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 +Y+ +G G +G+V+ + VA+K V D + + E+ LLK Sbjct: 5 SQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRL----DDDDEGVPSSALREICLLK 60 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSFFWQVLE 153 ++ ++RL D L+ E + QDL + G L E+ +SF +Q+L+ Sbjct: 61 ELKH--KNIVRLHDVLHSDKKLTLVFEFCD--QDLKKYFDSCNGDLDPEIVKSFLFQLLK 116 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPE 211 + CH+ VLHRD+K +N+LI+ N GELKL DFG V Y+ T Y PP+ Sbjct: 117 GLGFCHSRNVLHRDLKPQNLLINRN-GELKLADFGLARAFGIPVRCYSAEVVTLWYRPPD 175 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMV-CGDIPFEHDEEIIRGQVFFR-------------- 256 + + + S +WS G + ++ G F ++ + + FR Sbjct: 176 VLFGAKLYSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMT 235 Query: 257 ---------------------QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLL 295 ++++ + L++ L P R + EE HP+ D Sbjct: 236 KLPDYKPYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSDFCP 295 Query: 296 P 296 P Sbjct: 296 P 296 >1CM8-A nrPDB Length = 367 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 67/308 (21%), Positives = 123/308 (39%), Gaps = 54/308 (17%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 Y+ +GSG +G+V S + VAIK + + + R E+ LLK + Sbjct: 27 YRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRP----FQSELFAKRAYRELRLLKHMR 82 Query: 98 SGFSGVIRLLDWF------ERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQV 151 VI LLD F + F L++ DL + L E+ + +Q+ Sbjct: 83 H--ENVIGLLDVFTPDETLDDFTDFYLVMPFMGT--DLGKLMKHEK-LGEDRIQFLVYQM 137 Query: 152 LEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPE 211 L+ +R+ H G++HRD+K N+ ++ + ELK++DFG D+ T + TR Y PE Sbjct: 138 LKGLRYIHAAGIIHRDLKPGNLAVNED-CELKILDFGLARQ-ADSEMTGYVVTRWYRAPE 195 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR--------------- 256 I + ++ +WS+G ++ +M+ G F+ + + + + + Sbjct: 196 VILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQS 255 Query: 257 ----------------------QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVL 294 S +L+ L L R T E HP+ + + Sbjct: 256 DEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLH 315 Query: 295 LPQETAEI 302 ++ ++ Sbjct: 316 DTEDEPQV 323 >6GU6-A nrPDB Length = 302 Score = 228 bits (582), Expect = 2e-60, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 114/298 (38%), Gaps = 49/298 (16%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 Y +G G +G VY G + VA+K + + E + E+ LLK+ Sbjct: 7 EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLES----EEEGVPSTAIREISLLKE 62 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE---RGALQEELARSFFWQVL 152 + ++ L D + LI E DL ++ + L +S+ +Q+L Sbjct: 63 LRH--PNIVSLQDVLMQDSRLYLIFEFLS--MDLKKYLDSIPPGQYMDSSLVKSYLYQIL 118 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL--LKDTVYTDFDGTRVYSPP 210 + + CH+ VLHRD+K +N+LID ++G +KL DFG + VYT T Y P Sbjct: 119 QGIVFCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSP 177 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR-------------- 256 E + + +WS+G + ++ F D EI + FR Sbjct: 178 EVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVE 237 Query: 257 ---------------------QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 + + L+ L P+ R + + NHP+ D+ Sbjct: 238 SLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDL 295 >4FIE-A nrPDB Length = 423 Score = 227 bits (579), Expect = 6e-60, Method: Composition-based stats. Identities = 75/289 (25%), Positives = 127/289 (43%), Gaps = 27/289 (9%) Query: 25 LAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 84 + PG + L++ + +G G G V S VA+K ++ + L N Sbjct: 144 VDPGDPRSYLDNFIK----IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN-- 197 Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELA 144 EVV+++ V+ + + + D +++E E L D +T + EE Sbjct: 198 ----EVVIMRDYQH--ENVVEMYNSYLVGDELWVVMEFLEG-GALTDIVTHT-RMNEEQI 249 Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFD 202 + VL+A+ H GV+HRDIK ++IL+ + G +KL DFG A + V Sbjct: 250 AAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHD-GRVKLSDFGFCAQVSKEVPRRKSLV 308 Query: 203 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-----EEIIRGQVFFR- 256 GT + PE I Y G +WSLGI++ +MV G+ P+ ++ ++IR + R Sbjct: 309 GTPYWMAPELISRLPY-GPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRL 367 Query: 257 ---QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEI 302 +VS + + L P+ R T E+ HP++ P + Sbjct: 368 KNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPL 416 >2F57-A nrPDB Length = 317 Score = 226 bits (577), Expect = 9e-60, Method: Composition-based stats. Identities = 74/284 (26%), Positives = 124/284 (43%), Gaps = 29/284 (10%) Query: 25 LAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 84 ++PG +E L + + +G G G V VA+K ++ + L N Sbjct: 38 VSPGDPREYLANFIK----IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFN-- 91 Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELA 144 EVV+++ V+ + + D +++E E L D +T + EE Sbjct: 92 ----EVVIMRDYHHD--NVVDMYSSYLVGDELWVVMEFLEG-GALTDIVTHT-RMNEEQI 143 Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFD 202 + VL A+ + HN GV+HRDIK ++IL+ + G +KL DFG A + V Sbjct: 144 ATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSD-GRIKLSDFGFCAQVSKEVPKRKSLV 202 Query: 203 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSE 262 GT + PE I Y G +WSLGI++ +M+ G+ P+ +E ++ R + Sbjct: 203 GTPYWMAPEVISRLPY-GTEVDIWSLGIMVIEMIDGEPPYF-NEPPLQAMRRIRDSLPPR 260 Query: 263 CQHL----------IRWCLALRPSDRPTFEEIQNHPWMQDVLLP 296 + L + L PS R T +E+ HP+++ P Sbjct: 261 VKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPP 304 >3UTO-A nrPDB Length = 573 Score = 226 bits (577), Expect = 9e-60, Method: Composition-based stats. Identities = 73/285 (25%), Positives = 115/285 (40%), Gaps = 21/285 (7%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 89 + + + Y + LG+G FG V+ + A K V SD + E Sbjct: 151 KHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRK------E 204 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 + + + ++ L D FE + V+I E + E + E+ A + Sbjct: 205 IQTMSVLRH--PTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMR 262 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNR-GELKLIDFGSGALLK-DTVYTDFDGTRVY 207 QV + + H H +H D+K ENI+ R ELKLIDFG A L GT + Sbjct: 263 QVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEF 322 Query: 208 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHDEEIIRGQVFFR--------Q 257 + PE G +WS+G+L Y ++ G PF E+D+E +R Sbjct: 323 AAPEVAEGKPV-GYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFS 381 Query: 258 RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEI 302 +S + + IR L P+ R T + HPW+ P ++I Sbjct: 382 GISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQI 426 >4BBM-A nrPDB Length = 331 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 71/295 (24%), Positives = 119/295 (40%), Gaps = 47/295 (15%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +Y+ L+G G +G V VAIK + + E+ LLK+ Sbjct: 25 EKYENLGLVGEGSYGMVMKCRNKDTGRIVAIKKF----LESDDDKMVKKIAMREIKLLKQ 80 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 + ++ LL+ ++ + L+ E + L D L ++ + + +Q++ + Sbjct: 81 LRH--ENLVNLLEVCKKKKRWYLVFEFVDHT-ILDDLELFPNGLDYQVVQKYLFQIINGI 137 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPEWI 213 CH+ ++HRDIK ENIL+ + G +KL DFG L VY D TR Y PE + Sbjct: 138 GFCHSHNIIHRDIKPENILVSQS-GVVKLCDFGFARTLAAPGEVYDDEVATRWYRAPELL 196 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE--------------IIRGQVFFR--- 256 +G++ VW++G L+ +M G+ F D + I R Q F Sbjct: 197 VGDVKYGKAVDVWAIGCLVTEMFMGEPLFPGDSDIDQLYHIMMCLGNLIPRHQELFNKNP 256 Query: 257 --------------------QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 ++S L + CL + P RP E+ +H + Q Sbjct: 257 VFAGVRLPEIKEREPLERRYPKLSEVVIDLAKKCLHIDPDKRPFCAELLHHDFFQ 311 >4QNY-A nrPDB Length = 354 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 82/333 (24%), Positives = 132/333 (39%), Gaps = 68/333 (20%) Query: 7 NSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIR-VSDNLPVA 65 SLA L+A C L+ +Y + ++G+G +G V SDN VA Sbjct: 6 KSLAELQAEVCR---------------LDDRYLLERIIGAGSYGVVIRARDTKSDNRLVA 50 Query: 66 IKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWF-----ERPDSFVLIL 120 +K V K+ + E+ R+ E+ LL + +I L + E D F +++ Sbjct: 51 MKRVNKEI---FEEVILAKRILREIKLLAHFN--DDNIIGLRNILTPEDPENFDHFYIVM 105 Query: 121 ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG 180 + E DL + L E + F +Q L A+ H+ GV+HRDI NIL++ N Sbjct: 106 DIMET--DLKQVLRSGQELTEAHIQFFIYQALRALHIIHSAGVIHRDITPANILVNTN-C 162 Query: 181 ELKLIDFGSGALLKD--TVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCG 238 +LK+ DFG D TD+ R Y PE + + + VW +G +L +++ Sbjct: 163 DLKICDFGLAKEENDQGEYMTDYVTMRWYRAPELVMEDKDYSAQIDVWGIGCILGELLGS 222 Query: 239 DIPFEHDEEI----------------------------------IRGQVFFRQRV---SS 261 F+ + + R Q +RQR S Sbjct: 223 RPLFQGKDRVNQLDKIVDVIGTPSEEDINSVGSSAAQKYLKKKSHRPQADWRQRYPTASP 282 Query: 262 ECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVL 294 E L+R L P R T + HP+++ + Sbjct: 283 EALDLLRHMLVFNPKRRITVLQAMRHPFLEQLH 315 >4XBR-A nrPDB Length = 366 Score = 226 bits (576), Expect = 1e-59, Method: Composition-based stats. Identities = 75/289 (25%), Positives = 127/289 (43%), Gaps = 27/289 (9%) Query: 25 LAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 84 + PG + L++ + +G G G V S VA+K ++ + L N Sbjct: 87 VDPGDPRSYLDNFIK----IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN-- 140 Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELA 144 EVV+++ V+ + + + D +++E E L D +T + EE Sbjct: 141 ----EVVIMRDYQH--ENVVEMYNSYLVGDELWVVMEFLEG-GALTDIVTHT-RMNEEQI 192 Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFD 202 + VL+A+ H GV+HRDIK ++IL+ + G +KL DFG A + V Sbjct: 193 AAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHD-GRVKLSDFGFCAQVSKEVPRRKSLV 251 Query: 203 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-----EEIIRGQVFFR- 256 GT + PE I Y G +WSLGI++ +MV G+ P+ ++ ++IR + R Sbjct: 252 GTPYWMAPELISRLPY-GPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRL 310 Query: 257 ---QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEI 302 +VS + + L P+ R T E+ HP++ P + Sbjct: 311 KNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPL 359 >5DBX-A nrPDB Length = 328 Score = 225 bits (575), Expect = 1e-59, Method: Composition-based stats. Identities = 67/310 (21%), Positives = 123/310 (39%), Gaps = 41/310 (13%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 Y++ ++GSG V + + VAIK + ++ + + E+ + Sbjct: 10 RDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMD-----ELLKEIQAMS 64 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT--------ERGALQEELARS 146 + S V+ F D L+++ + D I + G L+E + + Sbjct: 65 QCSH--PNVVTYYTSFVVKDELWLVMKLLSG-GSMLDIIKYIVNRGEHKNGVLEEAIIAT 121 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL-------KDTVYT 199 +VLE + + H G +HRD+K NIL+ + G +++ DFG A L ++ V Sbjct: 122 ILKEVLEGLDYLHRNGQIHRDLKAGNILLGED-GSVQIADFGVSAFLATGGDVTRNKVRK 180 Query: 200 DFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF-------------EHDE 246 DF GT + PE + R + A +WS GI ++ G P+ ++D Sbjct: 181 DFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDP 240 Query: 247 EIIR---GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIH 303 + ++ + L+ CL PS RPT E+ + Q + E Sbjct: 241 PTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKL 300 Query: 304 LHSLSPGPSK 313 L + +P ++ Sbjct: 301 L-TRTPDIAQ 309 >4JDH-A nrPDB Length = 346 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 75/289 (25%), Positives = 127/289 (43%), Gaps = 27/289 (9%) Query: 25 LAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 84 + PG + L++ + +G G G V S VA+K ++ + L N Sbjct: 67 VDPGDPRSYLDNFIK----IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN-- 120 Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELA 144 EVV+++ V+ + + + D +++E E L D +T + EE Sbjct: 121 ----EVVIMRDYQH--ENVVEMYNSYLVGDELWVVMEFLEG-GALTDIVTHT-RMNEEQI 172 Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFD 202 + VL+A+ H GV+HRDIK ++IL+ + G +KL DFG A + V Sbjct: 173 AAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHD-GRVKLSDFGFCAQVSKEVPRRKSLV 231 Query: 203 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-----EEIIRGQVFFR- 256 GT + PE I Y G +WSLGI++ +MV G+ P+ ++ ++IR + R Sbjct: 232 GTPYWMAPELISRLPY-GPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRL 290 Query: 257 ---QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEI 302 +VS + + L P+ R T E+ HP++ P + Sbjct: 291 KNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPL 339 >4IC8-A nrPDB Length = 442 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 70/319 (21%), Positives = 120/319 (37%), Gaps = 58/319 (18%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +Y++ +G+G +G V S R VAIK + + + + N R E+ +LK Sbjct: 55 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIP----NAFDVVTNAKRTLRELKILKH 110 Query: 96 VSSGFSGVIRLLDW------FERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 +I + D + S ++L+ E DL I L E R F + Sbjct: 111 FKHD--NIIAIKDILRPTVPYGEFKSVYVVLDLMES--DLHQIIHSSQPLTLEHVRYFLY 166 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL------KDTVYTDFDG 203 Q+L +++ H+ V+HRD+K N+L++ N ELK+ DFG L T++ Sbjct: 167 QLLRGLKYMHSAQVIHRDLKPSNLLVNEN-CELKIGDFGMARGLCTSPAEHQYFMTEYVA 225 Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF-------- 255 TR Y PE + + ++ +WS+G + +M+ F + + Q+ Sbjct: 226 TRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSP 285 Query: 256 --------------------RQRVSSE---------CQHLIRWCLALRPSDRPTFEEIQN 286 RQ V E L+ L PS R + Sbjct: 286 AVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALR 345 Query: 287 HPWMQDVLLPQETAEIHLH 305 HP++ P + + Sbjct: 346 HPFLAKYHDPDDEPDCAPP 364 >2Q0N-A nrPDB Length = 301 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 75/289 (25%), Positives = 127/289 (43%), Gaps = 27/289 (9%) Query: 25 LAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 84 + PG + L++ + +G G G V S VA+K ++ + L N Sbjct: 22 VDPGDPRSYLDNFIK----IGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN-- 75 Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELA 144 EVV+++ V+ + + + D +++E E L D +T + EE Sbjct: 76 ----EVVIMRDYQH--ENVVEMYNSYLVGDELWVVMEFLEG-GALTDIVTHT-RMNEEQI 127 Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFD 202 + VL+A+ H GV+HRDIK ++IL+ + G +KL DFG A + V Sbjct: 128 AAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHD-GRVKLSDFGFCAQVSKEVPRRKSLV 186 Query: 203 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-----EEIIRGQVFFR- 256 GT + PE I Y G +WSLGI++ +MV G+ P+ ++ ++IR + R Sbjct: 187 GTPYWMAPELISRLPY-GPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRL 245 Query: 257 ---QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEI 302 +VS + + L P+ R T E+ HP++ P + Sbjct: 246 KNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPL 294 >6DTL-A nrPDB Length = 364 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 63/305 (20%), Positives = 115/305 (37%), Gaps = 51/305 (16%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 +G G +G V S + N VAIK + + + + R E+ LL+ + Sbjct: 37 PIGKGAYGIVCSAMNSETNESVAIKKI----ANAFDNKIDAKRTLREIKLLRHMDH--EN 90 Query: 103 VIRLLDWFERP-----DSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 ++ + D P + + E + DL I AL EE + F +Q+L +++ Sbjct: 91 IVAIRDIIPPPLRNAFNDVYIAYELMDT--DLHQIIRSNQALSEEHCQYFLYQILRGLKY 148 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPEWIRYH 216 H+ VLHRD+K N+L++ N +LK+ DFG + + T++ TR Y PE + Sbjct: 149 IHSANVLHRDLKPSNLLLNAN-CDLKICDFGLARVTSESDFMTEYVVTRWYRAPELLLNS 207 Query: 217 RYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR-------------------- 256 + + VWS+G + +++ F + + + ++ Sbjct: 208 SDYTAAIDVWSVGCIFMELMDRKPLFPGRDHVHQLRLLMELIGTPSEEELEFLNENAKRY 267 Query: 257 ----------------QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA 300 V LI L P R T + HP++ + + Sbjct: 268 IRQLPPYPRQSITDKFPTVHPLAIDLIEKMLTFDPRRRITVLDALAHPYLNSLHDISDEP 327 Query: 301 EIHLH 305 E + Sbjct: 328 ECTIP 332 >6ED6-A nrPDB Length = 415 Score = 225 bits (574), Expect = 2e-59, Method: Composition-based stats. Identities = 71/296 (23%), Positives = 130/296 (43%), Gaps = 26/296 (8%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVV 91 + Y V ++G G FG V + A+K + K + + E Sbjct: 84 QMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAF---FWEERD 140 Query: 92 LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQV 151 ++ +S + V++L F+ +++E P DL + ++ + E+ A+ + +V Sbjct: 141 IMAFANSPW--VVQLFYAFQDDRYLYMVMEYM-PGGDLVNLMSNYD-VPEKWAKFYTAEV 196 Query: 152 LEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT---DFDGTRVYS 208 + A+ H+ G++HRD+K +N+L+D G LKL DFG+ + +T GT Y Sbjct: 197 VLALDAIHSMGLIHRDVKPDNMLLD-KHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYI 255 Query: 209 PPEWIR---YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEII--------RGQVFFRQ 257 PE ++ ++GR WS+G+ LY+M+ GD PF D + + + F + Sbjct: 256 SPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPE 315 Query: 258 R--VSSECQHLIRWCLALRPSD--RPTFEEIQNHPWMQDVLLPQETAEIHLHSLSP 309 +S ++LI L R R EEI+ HP+ ++ + + P Sbjct: 316 DAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVP 371 >2UV2-A nrPDB Length = 325 Score = 225 bits (573), Expect = 2e-59, Method: Composition-based stats. Identities = 66/272 (24%), Positives = 114/272 (41%), Gaps = 26/272 (9%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 E +++ LG G FG VY ++ A K ++ + + +E+ +L Sbjct: 36 EDFWEIIGELGDGAFGKVYKAQNKETSVLAAAKVIDTKSEEELEDY------MVEIDILA 89 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 +++LLD F ++ +++E + L E + Q L+A Sbjct: 90 SCDH--PNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDA 147 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEW 212 + + H+ ++HRD+K NIL L+ G++KL DFG A T+ F GT + PE Sbjct: 148 LNYLHDNKIIHRDLKAGNILFTLD-GDIKLADFGVSAKNTRTIQRRDSFIGTPYWMAPEV 206 Query: 213 IRYH----RYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF----------RQR 258 + R + A VWSLGI L +M + P H+ +R + R Sbjct: 207 VMCETSKDRPYDYKADVWSLGITLIEMAEIEPP-HHELNPMRVLLKIAKSEPPTLAQPSR 265 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 SS + ++ CL R T ++ HP++ Sbjct: 266 WSSNFKDFLKKCLEKNVDARWTTSQLLQHPFV 297 >2FO0-A nrPDB Length = 495 Score = 225 bits (573), Expect = 2e-59, Method: Composition-based stats. Identities = 63/271 (23%), Positives = 118/271 (43%), Gaps = 25/271 (9%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 + E + + LG G +G VY G+ +L VA+K +++D + Sbjct: 210 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM-------EVEEFLK 262 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE--RGALQEELARS 146 E ++K++ +++LL R F +I E +L D++ E R + + Sbjct: 263 EAAVMKEIKH--PNLVQLLGVCTREPPFYIITEFMT-YGNLLDYLRECNRQEVNAVVLLY 319 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV 206 Q+ A+ + +HR++ N L+ N +K+ DFG L+ YT G + Sbjct: 320 MATQISSAMEYLEKKNFIHRNLAARNCLVGEN-HLVKVADFGLSRLMTGDTYTAHAGAKF 378 Query: 207 ---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDE-----EIIRGQVFF-- 255 ++ PE + Y+++ +S VW+ G+LL+++ G P+ + E++ Sbjct: 379 PIKWTAPESLAYNKFSIKS-DVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMER 437 Query: 256 RQRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 + + L+R C PSDRP+F EI Sbjct: 438 PEGCPEKVYELMRACWQWNPSDRPSFAEIHQ 468 >4XEY-B nrPDB Length = 408 Score = 224 bits (572), Expect = 3e-59, Method: Composition-based stats. Identities = 64/271 (23%), Positives = 118/271 (43%), Gaps = 25/271 (9%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 + E + + LG G +G VY G+ +L VA+K +++D + Sbjct: 118 DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM-------EVEEFLK 170 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE--RGALQEELARS 146 E ++K++ +++LL R F +I E +L D++ E R + + Sbjct: 171 EAAVMKEIKH--PNLVQLLGVCTREPPFYIITEFMT-YGNLLDYLRECNRQEVNAVVLLY 227 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV 206 Q+ A+ + +HRD+ N L+ N +K+ DFG L+ YT G + Sbjct: 228 MATQISSAMEYLEKKNFIHRDLAARNCLVGEN-HLVKVADFGLSRLMTGDTYTAHAGAKF 286 Query: 207 ---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDE-----EIIRGQVFF-- 255 ++ PE + Y+++ +S VW+ G+LL+++ G P+ + E++ Sbjct: 287 PIKWTAPESLAYNKFSIKS-DVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMER 345 Query: 256 RQRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 + + L+R C PSDRP+F EI Sbjct: 346 PEGCPEKVYELMRACWQWNPSDRPSFAEIHQ 376 >1KOA-A nrPDB Length = 491 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 73/285 (25%), Positives = 115/285 (40%), Gaps = 21/285 (7%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 89 + + + Y + LG+G FG V+ + A K V SD + E Sbjct: 45 KHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRK------E 98 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 + + + ++ L D FE + V+I E + E + E+ A + Sbjct: 99 IQTMSVLRH--PTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMR 156 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNR-GELKLIDFGSGALLK-DTVYTDFDGTRVY 207 QV + + H H +H D+K ENI+ R ELKLIDFG A L GT + Sbjct: 157 QVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEF 216 Query: 208 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHDEEIIRGQVFFR--------Q 257 + PE G +WS+G+L Y ++ G PF E+D+E +R Sbjct: 217 AAPEVAEGKPV-GYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFS 275 Query: 258 RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEI 302 +S + + IR L P+ R T + HPW+ P ++I Sbjct: 276 GISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQI 320 >6NPU-A nrPDB Length = 298 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 65/282 (23%), Positives = 121/282 (42%), Gaps = 25/282 (8%) Query: 18 NDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDW 77 +L+ + E + + LG G +G VY G+ +L VA+K +++D + Sbjct: 8 ENLYFQGSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTM--- 64 Query: 78 GELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-- 135 E ++K++ +++LL R F +I E +L D++ E Sbjct: 65 ----EVEEFLKEAAVMKEIKH--PNLVQLLGVCTREPPFYIITEFMT-YGNLLDYLRECN 117 Query: 136 RGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD 195 R + + Q+ A+ + +HRD+ N L+ N +K+ DFG L+ Sbjct: 118 RQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN-HLVKVADFGLSRLMTG 176 Query: 196 TVYTDFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDE----- 246 YT G + ++ PE + Y+++ +S VW+ G+LL+++ G P+ + Sbjct: 177 DTYTAHAGAKFPIKWTAPESLAYNKFSIKS-DVWAFGVLLWEIATYGMSPYPGIDLSQVY 235 Query: 247 EIIRGQVFF--RQRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 E++ + + L+R C PSDRP+F EI Sbjct: 236 ELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQ 277 >4U41-A nrPDB Length = 332 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 68/278 (24%), Positives = 111/278 (39%), Gaps = 34/278 (12%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 +++ ++G+G +G VY G V AIK ++ + + +E+ +LKK S Sbjct: 26 FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEE-------IKLEINMLKKYS 78 Query: 98 SGFSGVIRLLDWF------ERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFW 149 + F D L++E + D + L+E+ Sbjct: 79 H-HRNIATYYGAFIKKSPPGHDDQLWLVMEFC-GAGSITDLVKNTKGNTLKEDWIAYISR 136 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVY 207 ++L + H H V+HRDIK +N+L+ N E+KL+DFG A L TV F GT + Sbjct: 137 EILRGLAHLHIHHVIHRDIKGQNVLLTEN-AEVKLVDFGVSAQLDRTVGRRNTFIGTPYW 195 Query: 208 SPPEWIRYHRY----HGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSEC 263 PE I + + +WS GI +M G P D +R + Sbjct: 196 MAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPL-CDMHPMRALFLIPRNPPPRL 254 Query: 264 ---------QHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 I CL RP+ E++ HP+++D Sbjct: 255 KSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRD 292 >3OZ6-A nrPDB Length = 388 Score = 224 bits (571), Expect = 5e-59, Method: Composition-based stats. Identities = 68/353 (19%), Positives = 126/353 (35%), Gaps = 89/353 (25%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +Y++ LG G +G V+ I VA+K + + + R E+++L ++ Sbjct: 10 KYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKI----FDAFQNSTDAQRTFREIMILTEL 65 Query: 97 SSGFSGVIRLLDWFERPDS--FVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 S G ++ LL+ + L+ + E DL I L+ + +Q+++ Sbjct: 66 S-GHENIVNLLNVLRADNDRDVYLVFDYMET--DLHAVIRAN-ILEPVHKQYVVYQLIKV 121 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL--------------------- 193 +++ H+ G+LHRD+K NIL++ +K+ DFG Sbjct: 122 IKYLHSGGLLHRDMKPSNILLNAE-CHVKVADFGLSRSFVNIRRVTNNIPLSINENTENF 180 Query: 194 --KDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE----- 246 + TD+ TR Y PE + + + +WSLG +L +++CG F Sbjct: 181 DDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQL 240 Query: 247 ---------------------------EIIRGQVFFRQ---------------------R 258 E ++ +V RQ Sbjct: 241 ERIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKAD 300 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGP 311 + E L+ L P+ R + + HP++ P E E + + P Sbjct: 301 CNEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNE--EPNCDHIITIP 351 >4FR4-A nrPDB Length = 384 Score = 223 bits (570), Expect = 5e-59, Method: Composition-based stats. Identities = 63/272 (23%), Positives = 125/272 (45%), Gaps = 20/272 (7%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +++ +G G FG V + A+K++ K + + E+ N V E+ +++ Sbjct: 15 DHFEILRAIGKGSFGKVCIVQKNDTKKMYAMKYMNKQKCVERNEVRN---VFKELQIMQG 71 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 + F ++ L F+ + ++++ DL + + +EE + F +++ A+ Sbjct: 72 LEHPF--LVNLWYSFQDEEDMFMVVDLLLG-GDLRYHLQQNVHFKEETVKLFICELVMAL 128 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL-KDTVYTDFDGTRVYSPPEWIR 214 + N ++HRD+K +NIL+D G + + DF A+L ++T T GT+ Y PE Sbjct: 129 DYLQNQRIIHRDMKPDNILLD-EHGHVHITDFNIAAMLPRETQITTMAGTKPYMAPEMFS 187 Query: 215 YHR--YHGRSAAVWSLGILLYDMVCGDIPFE-----HDEEIIRGQ----VFFRQRVSSEC 263 + + + WSLG+ Y+++ G P+ +EI+ V + S E Sbjct: 188 SRKGAGYSFAVDWWSLGVTAYELLRGRRPYHIRSSTSSKEIVHTFETTVVTYPSAWSQEM 247 Query: 264 QHLIRWCLALRPSDRPT-FEEIQNHPWMQDVL 294 L++ L P R + ++QN P+M D+ Sbjct: 248 VSLLKKLLEPNPDQRFSQLSDVQNFPYMNDIN 279 >4MYG-A nrPDB Length = 372 Score = 223 bits (570), Expect = 5e-59, Method: Composition-based stats. Identities = 71/305 (23%), Positives = 121/305 (39%), Gaps = 55/305 (18%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 +GSG +GSV S I VAIK + + + R E++LLK + V Sbjct: 51 VGSGAYGSVCSAIDKRSGEKVAIKKLSRP----FQSEIFAKRAYRELLLLKHMQH--ENV 104 Query: 104 IRLLDWFERPDSF------VLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 I LLD F S L++ + DL + EE + +Q+L+ +++ Sbjct: 105 IGLLDVFTPASSLRNFYDFYLVMPFMQT--DLQKIM--GMEFSEEKIQYLVYQMLKGLKY 160 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHR 217 H+ GV+HRD+K N+ ++ + ELK++DFG D T + TR Y PE I Sbjct: 161 IHSAGVVHRDLKPGNLAVNED-CELKILDFGLARH-ADAEMTGYVVTRWYRAPEVILSWM 218 Query: 218 YHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR--------------------- 256 ++ ++ +WS+G ++ +M+ G F+ + + + + Sbjct: 219 HYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGTEFVQKLNDKAAKSY 278 Query: 257 ----------------QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA 300 R S + L+ L L R T + HP+ + P+E Sbjct: 279 IQSLPQTPRKDFTQLFPRASPQAADLLEKMLELDVDKRLTAAQALTHPFFEPFRDPEEET 338 Query: 301 EIHLH 305 E Sbjct: 339 EAQQP 343 >5Z33-A nrPDB Length = 425 Score = 223 bits (568), Expect = 9e-59, Method: Composition-based stats. Identities = 74/315 (23%), Positives = 127/315 (40%), Gaps = 55/315 (17%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 ++ +Y V LG G +G V + + + VAIK V + + + R E+ LL Sbjct: 29 VDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKV----TNVFSKKILAKRALREIKLL 84 Query: 94 KKVSSGFSGVIRLLDW-FERPDSF---VLILERPEPVQDLFDFITERGALQEELARSFFW 149 + G + L D RPD+F L E E DL I L + +SF + Sbjct: 85 QHFR-GHRNITCLYDMDIPRPDNFNETYLYEELMEC--DLAAIIRSGQPLTDAHFQSFIY 141 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL------KDTVYTDFDG 203 Q+L +++ H+ VLHRD+K N+L++ + ELK+ DFG T++ Sbjct: 142 QILCGLKYIHSANVLHRDLKPGNLLVNAD-CELKICDFGLARGFSVDPEENAGYMTEYVA 200 Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEI--------------- 248 TR Y PE + + + ++ VWS+G +L +++ G F+ + + Sbjct: 201 TRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNE 260 Query: 249 --------IRGQVFFR--------------QRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 R Q + R + + L+ LA PS R + E+ Sbjct: 261 ETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNANPDALDLLDRMLAFDPSSRISVEQALE 320 Query: 287 HPWMQDVLLPQETAE 301 HP++ + + Sbjct: 321 HPYLHIWHDASDEPD 335 >4KS7-A nrPDB Length = 292 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 69/266 (25%), Positives = 116/266 (43%), Gaps = 23/266 (8%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 +G G G V VA+K ++ + L N EVV+++ Sbjct: 30 KIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELLFN------EVVIMRDYQHF--N 81 Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCG 162 V+ + + + +++E + L D I + L EE + VL+A+ + H G Sbjct: 82 VVEMYKSYLVGEELWVLMEFLQG-GALTD-IVSQVRLNEEQIATVCEAVLQALAYLHAQG 139 Query: 163 VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEWIRYHRYHG 220 V+HRDIK ++IL+ L+ G +KL DFG A + V GT + PE I Y Sbjct: 140 VIHRDIKSDSILLTLD-GRVKLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYAT 198 Query: 221 RSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ---------RVSSECQHLIRWCL 271 +WSLGI++ +MV G+ P+ D + + +VS + + L Sbjct: 199 E-VDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERML 257 Query: 272 ALRPSDRPTFEEIQNHPWMQDVLLPQ 297 P +R T +E+ +HP++ LP+ Sbjct: 258 VRDPQERATAQELLDHPFLLQTGLPE 283 >6QAU-A nrPDB Length = 280 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 74/284 (26%), Positives = 126/284 (44%), Gaps = 28/284 (9%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRV-SDNLPVAIKHVEKDRISDWGELPNGTRV 86 G + + +Y L+G G F V+ G + VAIK + K +S L Sbjct: 3 GSMEVVGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGK--- 59 Query: 87 PMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARS 146 E+ +LK++ ++ L D E P+S L++E DL D++ +G L E+ R Sbjct: 60 --EIKILKELQH--ENIVALYDVQELPNSVFLVMEYCNG-GDLADYLQAKGTLSEDTIRV 114 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG--------ELKLIDFGSGALLKDTVY 198 F Q+ A+R H+ G++HRD+K +NIL+ +K+ DFG L + Sbjct: 115 FLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMM 174 Query: 199 -TDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE-EIIRGQVF-- 254 D G+ +Y PE I Y ++ +WS+G ++Y + G PF+ + + +R Sbjct: 175 AADLCGSPMYMAPEVIMSQHYDAKA-DLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKN 233 Query: 255 ------FRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 + S +L+ L DR FE +HP+++ Sbjct: 234 RSLMPSIPRETSPYLANLLLGLLQRNQKDRMDFEAFFSHPFLEQ 277 >4WNO-A nrPDB Length = 287 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 71/285 (24%), Positives = 128/285 (44%), Gaps = 30/285 (10%) Query: 27 PGKEKEPLESQYQVGPL--LGSGGFGSVYSGIRVSDN-LPVAIKHVEKDRISDWGELPNG 83 PG+ +++ +G G F V+ G + + L VA+K + K ++ L Sbjct: 7 PGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGK 66 Query: 84 TRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEEL 143 E+ +LK++ ++ L D+ E +S L++E DL D++ L E+ Sbjct: 67 -----EIKILKELKH--ENIVALYDFQEMANSVYLVMEYCNG-GDLADYLHAMRTLSEDT 118 Query: 144 ARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG--------ELKLIDFGSGALLKD 195 R F Q+ A+R H+ G++HRD+K +NIL+ G +K+ DFG L+ Sbjct: 119 IRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQS 178 Query: 196 TVY-TDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE-EIIRGQV 253 + G+ +Y PE I Y G++ +WS+G ++Y + G PF+ + +R Sbjct: 179 NMMAATLCGSPMYMAPEVIMSQHYDGKA-DLWSIGTIVYQCLTGKAPFQASSPQDLRLFY 237 Query: 254 F--------FRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 + S+ + L+ L DR F+E +HP++ Sbjct: 238 EKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL 282 >4ZSG-A nrPDB Length = 347 Score = 222 bits (567), Expect = 1e-58, Method: Composition-based stats. Identities = 70/319 (21%), Positives = 120/319 (37%), Gaps = 58/319 (18%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +Y++ +G+G +G V S R VAIK + + + + N R E+ +LK Sbjct: 7 DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIP----NAFDVVTNAKRTLRELKILKH 62 Query: 96 VSSGFSGVIRLLDW------FERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 +I + D + S ++L+ E DL I L E R F + Sbjct: 63 FKHD--NIIAIKDILRPTVPYGEFKSVYVVLDLMES--DLHQIIHSSQPLTLEHVRYFLY 118 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL------KDTVYTDFDG 203 Q+L +++ H+ V+HRD+K N+L++ N ELK+ DFG L T++ Sbjct: 119 QLLRGLKYMHSAQVIHRDLKPSNLLVNEN-CELKIGDFGMARGLCTSPAEHQYFMTEYVA 177 Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF-------- 255 TR Y PE + + ++ +WS+G + +M+ F + + Q+ Sbjct: 178 TRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSP 237 Query: 256 --------------------RQRVSSE---------CQHLIRWCLALRPSDRPTFEEIQN 286 RQ V E L+ L PS R + Sbjct: 238 AVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALR 297 Query: 287 HPWMQDVLLPQETAEIHLH 305 HP++ P + + Sbjct: 298 HPFLAKYHDPDDEPDCAPP 316 >6E2O-A nrPDB Length = 295 Score = 222 bits (566), Expect = 1e-58, Method: Composition-based stats. Identities = 72/282 (25%), Positives = 129/282 (45%), Gaps = 29/282 (10%) Query: 30 EKEPLESQYQVGP-----LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 84 E + LE Y+ +LG G +G VY+G +S+ + +AIK + +R S + + + Sbjct: 11 ESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEI-PERDSRYSQPLHE- 68 Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER-GALQ--E 141 E+ L K + +++ L F + +E+ P L + + G L+ E Sbjct: 69 ----EIALHKHLKH--KNIVQYLGSFSENGFIKIFMEQV-PGGSLSALLRSKWGPLKDNE 121 Query: 142 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD--TVYT 199 + + Q+LE +++ H+ ++HRDIK +N+LI+ G LK+ DFG+ L Sbjct: 122 QTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTE 181 Query: 200 DFDGTRVYSPPEWI-RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE---------II 249 F GT Y PE I + R +G++A +WSLG + +M G PF E + Sbjct: 182 TFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMF 241 Query: 250 RGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 + + +S+E + I C P R ++ +++ Sbjct: 242 KVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLK 283 >2WQN-A nrPDB Length = 310 Score = 222 bits (565), Expect = 2e-58, Method: Composition-based stats. Identities = 75/294 (25%), Positives = 118/294 (40%), Gaps = 24/294 (8%) Query: 7 NSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAI 66 ++ P K + +++ +G G F VY + D +PVA+ Sbjct: 3 EQSQGMQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRAACLLDGVPVAL 62 Query: 67 KHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPV 126 K V +I D + E+ LLK+++ VI+ F + ++LE + Sbjct: 63 KKV---QIFDLMDAKARADCIKEIDLLKQLNH--PNVIKYYASFIEDNELNIVLELAD-A 116 Query: 127 QDL----FDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL 182 DL F ++ + E +F Q+ A+ H H+ V+HRDIK N+ I G + Sbjct: 117 GDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITAT-GVV 175 Query: 183 KLIDFGSGALL--KDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI 240 KL D G G K T GT Y PE I + Y+ + +WSLG LLY+M Sbjct: 176 KLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYN-FKSDIWSLGCLLYEMAALQS 234 Query: 241 PFEHD--------EEIIRGQV--FFRQRVSSECQHLIRWCLALRPSDRPTFEEI 284 PF D ++I + S E + L+ C+ P RP + Sbjct: 235 PFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYV 288 >5EFQ-A nrPDB Length = 347 Score = 221 bits (563), Expect = 3e-58, Method: Composition-based stats. Identities = 74/320 (23%), Positives = 130/320 (40%), Gaps = 60/320 (18%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 ++ + ++G G +G VY VA+K V D + + E+ +L++ Sbjct: 11 DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPIT----AIREIKILRQ 66 Query: 96 VSSGFSGVIRL----------LDWFERPDSFVLILERPEPVQDLFDFITER-GALQEELA 144 ++ +I + LD+ + +F L+ E + DL + E Sbjct: 67 LTHQS--IINMKEIVTDKEDALDFKKDKGAFYLVFEYMDH--DLMGLLESGLVHFNENHI 122 Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV---YTDF 201 +SF Q++E + +CH LHRDIK NIL++ NRG++KL DFG L YT+ Sbjct: 123 KSFMRQLMEGLDYCHKKNFLHRDIKCSNILLN-NRGQIKLADFGLARLYSSEESRPYTNK 181 Query: 202 DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEI------------- 248 T Y PPE + + + VWS G +L ++ F+ ++E+ Sbjct: 182 VITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSP 241 Query: 249 ----------------IRGQVFFRQRVSSE-------CQHLIRWCLALRPSDRPTFEEIQ 285 ++ + +R+++ E L + LAL PS R T E+ Sbjct: 242 CPAVWPDVIKLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQAL 301 Query: 286 NHPWMQDVLLPQETAEIHLH 305 +++DV P + L Sbjct: 302 QCEFLRDV-EPSKMPPPDLP 320 >2BRG-A nrPDB Length = 297 Score = 221 bits (563), Expect = 3e-58, Method: Composition-based stats. Identities = 70/275 (25%), Positives = 117/275 (42%), Gaps = 22/275 (8%) Query: 33 PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVL 92 P + + LG G +G V + VA+K V+ R D E + E+ + Sbjct: 4 PFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPE-----NIKKEICI 58 Query: 93 LKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 K ++ V++ + L LE +LFD I + E A+ FF Q++ Sbjct: 59 NKMLNH--ENVVKFYGHRREGNIQYLFLEYCSG-GELFDRIEPDIGMPEPDAQRFFHQLM 115 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL----KDTVYTDFDGTRVYS 208 V + H G+ HRDIK EN+L+D LK+ DFG + ++ + GT Y Sbjct: 116 AGVVYLHGIGITHRDIKPENLLLDERDN-LKISDFGLATVFRYNNRERLLNKMCGTLPYV 174 Query: 209 PPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR---------QRV 259 PE ++ +H VWS GI+L M+ G++P++ + + ++ +++ Sbjct: 175 APELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKI 234 Query: 260 SSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVL 294 S L+ L PS R T +I+ W L Sbjct: 235 DSAPLALLHKILVENPSARITIPDIKKDRWYNKPL 269 >4OTD-A nrPDB Length = 341 Score = 220 bits (562), Expect = 4e-58, Method: Composition-based stats. Identities = 67/288 (23%), Positives = 120/288 (41%), Gaps = 21/288 (7%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 ++ +LG G FG V AIK ++K I E+ + + E +L Sbjct: 12 EDFKFLAVLGRGHFGKVLLSEFRPSGELFAIKALKKGDIVARDEVES---LMCEKRILAA 68 Query: 96 V-SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 V S+G ++ L F+ P+ ++E DL I E A + V+ Sbjct: 69 VTSAGHPFLVNLFGCFQTPEHVCFVMEYSAG-GDLMLHIHS-DVFSEPRAIFYSACVVLG 126 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA--LLKDTVYTDFDGTRVYSPPEW 212 ++ H +++RD+K + L+ G +K+ DFG + + F GT + PE Sbjct: 127 LQFLHEHKIVYRDLKLD-NLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEV 185 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRVSSECQHL 266 + + R+ W LG+LLY+M+ G+ PF D+E I+ +V + + +S+E + Sbjct: 186 L-TDTSYTRAVDWWGLGVLLYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSAEAIGI 244 Query: 267 IRWCLALRPSDRPT-----FEEIQNHPWMQDVLLPQETAEIHLHSLSP 309 +R L P R E+++ P+ + + A P Sbjct: 245 MRRLLRRNPERRLGSSERDAEDVKKQPFFRTLGWEALLARRLPPPFVP 292 >1NY3-A nrPDB Length = 400 Score = 220 bits (562), Expect = 4e-58, Method: Composition-based stats. Identities = 82/292 (28%), Positives = 123/292 (42%), Gaps = 37/292 (12%) Query: 30 EKEPLESQYQV-GPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 +K + Y+V +LG G G V A+K ++ + + Sbjct: 55 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-----------DCPKARR 103 Query: 89 EVVLLKKVSSGFSGVIRLLDWFER---PDSFVLILERPEPVQDLFDFITERG--ALQEEL 143 EV L + S ++R++D +E +LI+ +LF I +RG A E Sbjct: 104 EVELHWRASQC-PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 162 Query: 144 ARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE--LKLIDFGSGALLK-DTVYTD 200 A + EA+++ H+ + HRD+K EN+L R LKL DFG T Sbjct: 163 ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT 222 Query: 201 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE----------EIIR 250 T Y PE + +Y +S +WSLG+++Y ++CG PF + I Sbjct: 223 PCYTPYYVAPEVLGPEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRM 281 Query: 251 GQVFFRQR----VSSECQHLIRWCLALRPSDRPTFEEIQNHPWM-QDVLLPQ 297 GQ F VS E + LIR L P+ R T E NHPW+ Q +PQ Sbjct: 282 GQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 333 >3KA0-A nrPDB Length = 320 Score = 220 bits (561), Expect = 6e-58, Method: Composition-based stats. Identities = 82/292 (28%), Positives = 124/292 (42%), Gaps = 37/292 (12%) Query: 30 EKEPLESQYQV-GPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 +K + Y+V +LG G G V A+K ++ + + Sbjct: 9 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-----------DCPKARR 57 Query: 89 EVVLLKKVSSGFSGVIRLLDWFER---PDSFVLILERPEPVQDLFDFITERG--ALQEEL 143 EV L + S ++R++D +E +LI+ +LF I +RG A E Sbjct: 58 EVELHWRASQC-PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 116 Query: 144 ARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE--LKLIDFGSGALLK-DTVYTD 200 A + EA+++ H+ + HRD+K EN+L R LKL DFG T+ Sbjct: 117 ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTE 176 Query: 201 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE----------EIIR 250 T Y PE + +Y +S +WSLG+++Y ++CG PF + I Sbjct: 177 PCYTPYYVAPEVLGPEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRM 235 Query: 251 GQVFFRQR----VSSECQHLIRWCLALRPSDRPTFEEIQNHPWM-QDVLLPQ 297 GQ F VS E + LIR L P+ R T E NHPW+ Q +PQ Sbjct: 236 GQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 287 >3GC9-A nrPDB Length = 370 Score = 220 bits (560), Expect = 7e-58, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 123/313 (39%), Gaps = 54/313 (17%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 + Q +GSG +GSV S VA+K + + + L + R E+ LLK + Sbjct: 29 RLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP----FQSLIHARRTYRELRLLKHL 84 Query: 97 SSGFSGVIRLLDWF------ERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQ 150 VI LLD F E L+ DL + + AL +E + +Q Sbjct: 85 KH--ENVIGLLDVFTPATSIEDFSEVYLVTTLMGA--DLNNIVKS-QALSDEHVQFLVYQ 139 Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPP 210 +L +++ H+ G++HRD+K N+ ++ + EL+++DFG D T + TR Y P Sbjct: 140 LLRGLKYIHSAGIIHRDLKPSNVAVNED-SELRILDFGLARQ-ADEEMTGYVATRWYRAP 197 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR----------QRVS 260 E + ++ ++ +WS+G ++ +++ G F + I + + ++S Sbjct: 198 EIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS 257 Query: 261 SE---------------------------CQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 SE L+ L L R + E H + Sbjct: 258 SEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQY 317 Query: 294 LLPQETAEIHLHS 306 P++ E + Sbjct: 318 HDPEDEPEAEPYD 330 >6CKI-A nrPDB Length = 316 Score = 220 bits (560), Expect = 7e-58, Method: Composition-based stats. Identities = 75/299 (25%), Positives = 118/299 (39%), Gaps = 49/299 (16%) Query: 34 LESQYQVGP-LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVL 92 E YQ+ +LG G V + I + + A+K +EK +RV EV + Sbjct: 10 FEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGH------IRSRVFREVEM 63 Query: 93 LKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 L + G V+ L+++FE D F L+ E+ + I +R E A V Sbjct: 64 LYQCQ-GHRNVLELIEFFEEEDRFYLVFEKMRG-GSILSHIHKRRHFNELEASVVVQDVA 121 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNR--GELKLIDFGSGALLK---------DTVYTDF 201 A+ HN G+ HRD+K ENIL + +K+ DFG G+ +K Sbjct: 122 SALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFGLGSGIKLNGDCSPISTPELLTP 181 Query: 202 DGTRVYSPPEWIRYHRY----HGRSAAVWSLGILLYDMVCGDIPFEHD------------ 245 G+ Y PE + + + +WSLG++LY ++ G PF Sbjct: 182 CGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEA 241 Query: 246 ---------EEIIRGQVFFRQR----VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 E I G+ F + +S + LI L R + ++ HPW+Q Sbjct: 242 CPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQ 300 >2OZA-A nrPDB Length = 356 Score = 220 bits (560), Expect = 8e-58, Method: Composition-based stats. Identities = 82/292 (28%), Positives = 123/292 (42%), Gaps = 37/292 (12%) Query: 30 EKEPLESQYQV-GPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 +K + Y+V +LG G G V A+K ++ + + Sbjct: 11 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-----------DCPKARR 59 Query: 89 EVVLLKKVSSGFSGVIRLLDWFER---PDSFVLILERPEPVQDLFDFITERG--ALQEEL 143 EV L + S ++R++D +E +LI+ +LF I +RG A E Sbjct: 60 EVELHWRASQC-PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 118 Query: 144 ARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE--LKLIDFGSGALLK-DTVYTD 200 A + EA+++ H+ + HRD+K EN+L R LKL DFG T Sbjct: 119 ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTT 178 Query: 201 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE----------EIIR 250 T Y PE + +Y +S +WSLG+++Y ++CG PF + I Sbjct: 179 PCYTPYYVAPEVLGPEKY-DKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRM 237 Query: 251 GQVFFRQR----VSSECQHLIRWCLALRPSDRPTFEEIQNHPWM-QDVLLPQ 297 GQ F VS E + LIR L P+ R T E NHPW+ Q +PQ Sbjct: 238 GQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 289 >1V0B-A nrPDB Length = 288 Score = 219 bits (559), Expect = 9e-58, Method: Composition-based stats. Identities = 67/295 (22%), Positives = 115/295 (38%), Gaps = 48/295 (16%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +Y +G G +G VY A+K + ++ + + E+ +LK+ Sbjct: 2 EKYHGLEKIGEGTYGVVYKAQNNY-GETFALKKIRLEK----EDEGIPSTTIREISILKE 56 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT-ERGALQEELARSFFWQVLEA 154 + +++L D VL+ E + QDL + G L+ A+SF Q+L Sbjct: 57 LKHS--NIVKLYDVIHTKKRLVLVFEHLD--QDLKKLLDVCEGGLESVTAKSFLLQLLNG 112 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPEW 212 + +CH+ VLHRD+K +N+LI+ GELK+ DFG V YT T Y P+ Sbjct: 113 IAYCHDRRVLHRDLKPQNLLINRE-GELKIADFGLARAFGIPVRKYTHEVVTLWYRAPDV 171 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR---------------- 256 + + + + +WS+G + +MV G F E + FR Sbjct: 172 LMGSKKYSTTIDIWSVGCIFAEMVNGAPLFPGVSEADQLMRIFRILGTPNSKNWPNVTEL 231 Query: 257 QRVSSEC-------------------QHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 + L+ L L P+ R T ++ H + ++ Sbjct: 232 PKYDPNFTVYEPLPWESFLKGLDESGIDLLSKMLKLDPNQRITAKQALEHAYFKE 286 >5O0Y-A nrPDB Length = 579 Score = 219 bits (558), Expect = 1e-57, Method: Composition-based stats. Identities = 79/318 (24%), Positives = 140/318 (44%), Gaps = 33/318 (10%) Query: 3 LSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNL 62 L ++ + +L +H + K+ L +Y + LLG GGF VY +++ Sbjct: 251 LERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQR 310 Query: 63 PVAIKHVEKDR-ISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWF-ERPDSFVLIL 120 VA+K + ++ D + E + K++ +++L D+F DSF +L Sbjct: 311 YVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDH--PRIVKLYDYFSLDTDSFCTVL 368 Query: 121 ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCG--VLHRDIKDENILI--D 176 E E DL ++ + + E+ ARS Q++ A+++ + ++H D+K NIL+ Sbjct: 369 EYCEG-NDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNG 427 Query: 177 LNRGELKLIDFGSGALLKDTVYTDFD---------GTRVYSPPEWIRYHRYHGR---SAA 224 GE+K+ DFG ++ D Y D GT Y PPE + + Sbjct: 428 TACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVD 487 Query: 225 VWSLGILLYDMVCGDIPFEHDE------------EIIRGQVFFRQRVSSECQHLIRWCLA 272 VWS+G++ Y + G PF H++ + Q + V+ E + IR CLA Sbjct: 488 VWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLA 547 Query: 273 LRPSDRPTFEEIQNHPWM 290 R DR +++ P++ Sbjct: 548 YRKEDRIDVQQLACDPYL 565 >4UY9-A nrPDB Length = 323 Score = 219 bits (558), Expect = 1e-57, Method: Composition-based stats. Identities = 60/267 (22%), Positives = 105/267 (39%), Gaps = 27/267 (10%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 + + ++G GGFG VY + D VA+K D D + R E L + Sbjct: 10 ELTLEEIIGIGGFGKVYRAFWIGD--EVAVKAARHDPDEDISQTIENVR--QEAKLFAML 65 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156 +I L + + L++E + + + ++ ++ Q+ + Sbjct: 66 KH--PNIIALRGVCLKEPNLCLVMEFARGGP--LNRVLSGKRIPPDILVNWAVQIARGMN 121 Query: 157 HCHNCGV---LHRDIKDENILI-------DLNRGELKLIDFGSGALLKDTVYTDFDGTRV 206 + H+ + +HRD+K NILI DL+ LK+ DFG T GT Sbjct: 122 YLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGTYA 181 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQ--------VFFRQR 258 + PE IR + + + VWS G+LL++++ G++PF + + + Sbjct: 182 WMAPEVIRASMF-SKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPST 240 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQ 285 L+ C P RP+F I Sbjct: 241 CPEPFAKLMEDCWNPDPHSRPSFTNIL 267 >1KOB-A nrPDB Length = 387 Score = 218 bits (556), Expect = 2e-57, Method: Composition-based stats. Identities = 69/269 (25%), Positives = 113/269 (42%), Gaps = 23/269 (8%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 Y + LGSG FG V+ + + K + D + N E+ ++ + Sbjct: 51 DYYDILEELGSGAFGVVHRCVEKATGRVFVAKFINTPYPLDKYTVKN------EISIMNQ 104 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA-LQEELARSFFWQVLEA 154 + +I L D FE VLILE +LFD I + E ++ Q E Sbjct: 105 LHH--PKLINLHDAFEDKYEMVLILEFLSG-GELFDRIAAEDYKMSEAEVINYMRQACEG 161 Query: 155 VRHCHNCGVLHRDIKDENILIDLNR-GELKLIDFGSGALLK-DTVYTDFDGTRVYSPPEW 212 ++H H ++H DIK ENI+ + + +K+IDFG L D + T ++ PE Sbjct: 162 LKHMHEHSIVHLDIKPENIMCETKKASSVKIIDFGLATKLNPDEIVKVTTATAEFAAPEI 221 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR----------QRVSSE 262 + G +W++G+L Y ++ G PF ++++ Q R VS E Sbjct: 222 VDREPV-GFYTDMWAIGVLGYVLLSGLSPFAGEDDLETLQNVKRCDWEFDEDAFSSVSPE 280 Query: 263 CQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 + I+ L P R T + HPW++ Sbjct: 281 AKDFIKNLLQKEPRKRLTVHDALEHPWLK 309 >3DTC-A nrPDB Length = 271 Score = 218 bits (556), Expect = 3e-57, Method: Composition-based stats. Identities = 59/267 (22%), Positives = 104/267 (38%), Gaps = 27/267 (10%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 + + ++G GGFG VY + D VA+K D D + R E L + Sbjct: 8 ELTLEEIIGIGGFGKVYRAFWIGD--EVAVKAARHDPDEDISQTIENVR--QEAKLFAML 63 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVR 156 +I L + + L++E + + + ++ ++ Q+ + Sbjct: 64 KH--PNIIALRGVCLKEPNLCLVMEFARGGP--LNRVLSGKRIPPDILVNWAVQIARGMN 119 Query: 157 HCHNCGV---LHRDIKDENILI-------DLNRGELKLIDFGSGALLKDTVYTDFDGTRV 206 + H+ + +HRD+K NILI DL+ LK+ DFG T G Sbjct: 120 YLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAREWHRTTKMSAAGAYA 179 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQ--------VFFRQR 258 + PE IR + + + VWS G+LL++++ G++PF + + + Sbjct: 180 WMAPEVIRASMF-SKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLALPIPST 238 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQ 285 L+ C P RP+F I Sbjct: 239 CPEPFAKLMEDCWNPDPHSRPSFTNIL 265 >5AIR-A nrPDB Length = 430 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 75/332 (22%), Positives = 126/332 (37%), Gaps = 61/332 (18%) Query: 26 APGKEKEPLES-QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGT 84 PG+ + + Y ++G+G FG VY VAIK V +D+ Sbjct: 53 TPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFK-------- 104 Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWF----ERPDSFVL--ILERP--EPVQDLFDFITER 136 E+ +++K+ ++RL +F E+ D L +L+ + + + Sbjct: 105 --NRELQIMRKLDHC--NIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAK 160 Query: 137 GALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL-KD 195 L + + +Q+ ++ + H+ G+ HRDIK +N+L+D + LKL DFGS L + Sbjct: 161 QTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRG 220 Query: 196 TVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EII 249 + +R Y PE I + S VWS G +L +++ G F D EII Sbjct: 221 EPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEII 280 Query: 250 R-----------------------------GQVFFRQRVSSECQHLIRWCLALRPSDRPT 280 + FR R E L L P+ R T Sbjct: 281 KVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLT 340 Query: 281 FEEIQNHPWMQDVLLPQETAEIHLHSLSPGPS 312 E H + ++ P + L + P+ Sbjct: 341 PLEACAHSFFDELRDP----NVKLPNGRDTPA 368 >4NST-A nrPDB Length = 351 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 73/320 (22%), Positives = 127/320 (39%), Gaps = 59/320 (18%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 ++ + ++G G +G VY VA+K V D + + E+ +L++ Sbjct: 13 DKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPIT----AIREIKILRQ 68 Query: 96 VSSGFSGVIRL----------LDWFERPDSFVLILERPEPVQDLFDFITER-GALQEELA 144 + V+ + LD+ + +F L+ E + DL + E+ Sbjct: 69 LIHRS--VVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDH--DLMGLLESGLVHFSEDHI 124 Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV---YTDF 201 +SF Q++E + +CH LHRDIK NIL++ N G++KL DFG L YT+ Sbjct: 125 KSFMKQLMEGLEYCHKKNFLHRDIKCSNILLN-NSGQIKLADFGLARLYNSEESRPYTNK 183 Query: 202 DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEI------------- 248 T Y PPE + + + VWS G +L ++ F+ + E+ Sbjct: 184 VITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSP 243 Query: 249 ----------------IRGQVFFRQRVSSE-------CQHLIRWCLALRPSDRPTFEEIQ 285 ++ + +R+R+ E L+ L L PS R T E+ Sbjct: 244 CPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTL 303 Query: 286 NHPWMQDVLLPQETAEIHLH 305 +++DV L + H Sbjct: 304 QSDFLKDVELSKMAPPDLPH 323 >6CCF-A nrPDB Length = 290 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 71/291 (24%), Positives = 121/291 (41%), Gaps = 39/291 (13%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDW------------------ 77 +QY++ +G G +G V S++ A+K + K ++ Sbjct: 5 NQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQAAQGG 64 Query: 78 --GELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERP--DSFVLILERPEPVQDLFDFI 133 +L RV E+ +LKK+ V++L++ + P D+ L+ + + + Sbjct: 65 PAKQLLPLERVYQEIAILKKLDHV--NVVKLIEVLDDPAEDNLYLVFDLLRKGPVME--V 120 Query: 134 TERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL 193 EE AR + V+ + + H ++HRDIK N+L+ + G +K+ DFG Sbjct: 121 PCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLG-DDGHVKIADFGVSNQF 179 Query: 194 K--DTVYTDFDGTRVYSPPEWI--RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD---- 245 + D + GT + PE I + G++ VW+ G+ LY V G PF D Sbjct: 180 EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA 239 Query: 246 --EEIIRGQVFFR--QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 +I V F +S E + LI L P R +I+ HPW+ Sbjct: 240 LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTK 290 >2WTK-C nrPDB Length = 305 Score = 218 bits (555), Expect = 3e-57, Method: Composition-based stats. Identities = 68/288 (23%), Positives = 116/288 (40%), Gaps = 20/288 (6%) Query: 33 PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVL 92 L +Y +G LLG G +G V + A+ + V E+ L Sbjct: 2 KLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAV--KILKKKKLRRIPNGEANVKKEIQL 59 Query: 93 LKKVSSGFSGVIRLLDWF--ERPDSFVLILERP-EPVQDLFDFITERGALQEELARSFFW 149 L+++ VI+L+D E +++E +Q++ D + E+ A +F Sbjct: 60 LRRLRH--KNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDSVPEK-RFPVCQAHGYFC 116 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK----DTVYTDFDGTR 205 Q+++ + + H+ G++H+DIK N+L+ G LK+ G L D G+ Sbjct: 117 QLIDGLEYLHSQGIVHKDIKPGNLLLTTG-GTLKISALGVAEALHPFAADDTCRTSQGSP 175 Query: 206 VYSPPEWIRY-HRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQVFFRQR 258 + PPE + G +WS G+ LY++ G PFE D E I +G Sbjct: 176 AFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGD 235 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHS 306 L++ L P+ R + +I+ H W + P E S Sbjct: 236 CGPPLSDLLKGMLEYEPAKRFSIRQIRQHSWFRKKHPPAEAPVPIPPS 283 >3GC0-A nrPDB Length = 329 Score = 217 bits (554), Expect = 4e-57, Method: Composition-based stats. Identities = 66/298 (22%), Positives = 109/298 (36%), Gaps = 50/298 (16%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +Y+ LG G +G VY I N VAIK + + E EV LLK+ Sbjct: 34 DRYRRITKLGEGTYGEVYKAIDTVTNETVAIKRIRLE----HEEEGVPGTAIREVSLLKE 89 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 + +I L LI E E DL ++ + + + +SF +Q++ V Sbjct: 90 LQHR--NIIELKSVIHHNHRLHLIFEYAEN--DLKKYMDKNPDVSMRVIKSFLYQLINGV 145 Query: 156 RHCHNCGVLHRDIKDENILID----LNRGELKLIDFGSGAL--LKDTVYTDFDGTRVYSP 209 CH+ LHRD+K +N+L+ LK+ DFG + +T T Y P Sbjct: 146 NFCHSRRCLHRDLKPQNLLLSVSDASETPVLKIGDFGLARAFGIPIRQFTHEIITLWYRP 205 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIR------------------- 250 PE + R++ S +WS+ + +M+ F D EI + Sbjct: 206 PEILLGSRHYSTSVDIWSIACIWAEMLMKTPLFPGDSEIDQLFKIFEVLGLPDDTTWPGV 265 Query: 251 -----GQVFFRQRVSSECQHLI------------RWCLALRPSDRPTFEEIQNHPWMQ 291 + F + + ++ L + P R + + HP+ Sbjct: 266 TALPDWKQSFPKFRGKTLKRVLGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYFS 323 >4QTB-A nrPDB Length = 380 Score = 217 bits (553), Expect = 5e-57, Method: Composition-based stats. Identities = 65/317 (20%), Positives = 113/317 (35%), Gaps = 60/317 (18%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +Y +G G +G V S VAIK + S + R E+ +L + Sbjct: 42 RYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKI-----SPFEHQTYCQRTLREIQILLRF 96 Query: 97 SSGFSGVIRLLDWF-----ERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQV 151 VI + D E ++ + E DL+ + + L + F +Q+ Sbjct: 97 RH--ENVIGIRDILRASTLEAMRDVYIVQDLMET--DLYKLLKSQQ-LSNDHICYFLYQI 151 Query: 152 LEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL-----KDTVYTDFDGTRV 206 L +++ H+ VLHRD+K N+LI+ +LK+ DFG + T++ TR Sbjct: 152 LRGLKYIHSANVLHRDLKPSNLLINTT-CDLKICDFGLARIADPEHDHTGFLTEYVATRW 210 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIR---------------- 250 Y PE + + + +S +WS+G +L +M+ F + + Sbjct: 211 YRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDL 270 Query: 251 ----------------------GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHP 288 F + S L+ L P+ R T EE HP Sbjct: 271 NCIINMKARNYLQSLPSKTKVAWAKLFPKSDSK-ALDLLDRMLTFNPNKRITVEEALAHP 329 Query: 289 WMQDVLLPQETAEIHLH 305 +++ P + Sbjct: 330 YLEQYYDPTDEPVAEEP 346 >2XYN-A nrPDB Length = 292 Score = 217 bits (553), Expect = 6e-57, Method: Composition-based stats. Identities = 60/268 (22%), Positives = 116/268 (43%), Gaps = 25/268 (9%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 + E + + LG G +G VY G+ +L VA+K +++D + Sbjct: 25 DKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTM-------EVEEFLK 77 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE--RGALQEELARS 146 E ++K++ +++LL F ++ E P +L D++ E R + + Sbjct: 78 EAAVMKEIKH--PNLVQLLGVCTLEPPFYIVTEYM-PYGNLLDYLRECNREEVTAVVLLY 134 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV 206 Q+ A+ + +HRD+ N L+ N +K+ DFG L+ YT G + Sbjct: 135 MATQISSAMEYLEKKNFIHRDLAARNCLVGEN-HVVKVADFGLSRLMTGDTYTAHAGAKF 193 Query: 207 ---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDE-----EIIRGQVFF-- 255 ++ PE + Y+ + +S VW+ G+LL+++ G P+ + +++ Sbjct: 194 PIKWTAPESLAYNTFSIKS-DVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQ 252 Query: 256 RQRVSSECQHLIRWCLALRPSDRPTFEE 283 + + L+R C P+DRP+F E Sbjct: 253 PEGCPPKVYELMRACWKWSPADRPSFAE 280 >5NGU-A nrPDB Length = 381 Score = 217 bits (552), Expect = 7e-57, Method: Composition-based stats. Identities = 61/317 (19%), Positives = 111/317 (35%), Gaps = 60/317 (18%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +Y +G G +G V S + + VAIK + S + R E+ +L + Sbjct: 43 RYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKI-----SPFEHQTYCQRTLREIKILLRF 97 Query: 97 SSGFSGVIRLLDWFERPD-----SFVLILERPEPVQDLFDFITERGALQEELARSFFWQV 151 +I + D P ++ + E DL+ + L + F +Q+ Sbjct: 98 RH--ENIIGINDIIRAPTIEQMKDVYIVQDLMET--DLYKLLK-TQHLSNDHICYFLYQI 152 Query: 152 LEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA-----LLKDTVYTDFDGTRV 206 L +++ H+ VLHRD+K N+L++ +LK+ DFG T++ TR Sbjct: 153 LRGLKYIHSANVLHRDLKPSNLLLNTT-CDLKICDFGLARVADPDHDHTGFLTEYVATRW 211 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIR---------------- 250 Y PE + + + +S +WS+G +L +M+ F + + Sbjct: 212 YRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDL 271 Query: 251 ----------------------GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHP 288 F S+ L+ L P R E+ HP Sbjct: 272 NCIINLKARNYLLSLPHKNKVPWNRLFP-NADSKALDLLDKMLTFNPHKRIEVEQALAHP 330 Query: 289 WMQDVLLPQETAEIHLH 305 +++ P + Sbjct: 331 YLEQYYDPSDEPIAEAP 347 >4APC-A nrPDB Length = 350 Score = 216 bits (550), Expect = 1e-56, Method: Composition-based stats. Identities = 78/299 (26%), Positives = 124/299 (41%), Gaps = 30/299 (10%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +Y +G G FG D IK + R+S + EV +L Sbjct: 24 EKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESR----REVAVLAN 79 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA--LQEELARSFFWQVLE 153 + +++ + FE S ++++ E DLF I + QE+ +F Q+ Sbjct: 80 MKH--PNIVQYRESFEENGSLYIVMDYCEG-GDLFKRINAQKGVLFQEDQILDWFVQICL 136 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--YTDFDGTRVYSPPE 211 A++H H+ +LHRDIK +NI + + G ++L DFG +L TV GT Y PE Sbjct: 137 ALKHVHDRKILHRDIKSQNIFLTKD-GTVQLGDFGIARVLNSTVELARACIGTPYYLSPE 195 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EIIRGQVFF-RQRVSSECQ 264 Y+ +S +W+LG +LY++ FE +II G S + + Sbjct: 196 ICENKPYNNKS-DIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLR 254 Query: 265 HLIRWCLALRPSDRPTFEEIQNHPW----MQDVLLPQETAEI-HLHSLS-----PGPSK 313 L+ P DRP+ I + ++ L PQ AE L + S P P+K Sbjct: 255 SLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAK 313 >5UUU-A nrPDB Length = 547 Score = 215 bits (549), Expect = 1e-56, Method: Composition-based stats. Identities = 69/289 (23%), Positives = 119/289 (41%), Gaps = 20/289 (6%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 + + V ++G GGFG VY + A+K ++K RI T E ++L Sbjct: 198 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQ---GETLALNERIMLSL 254 Query: 96 VSSGF-SGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 VS+G ++ + F PD IL+ DL +++ G E R + +++ Sbjct: 255 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNG-GDLHYHLSQHGVFSEADMRFYAAEIILG 313 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIR 214 + H HN V++RD+K NIL+D G +++ D G GT Y PE ++ Sbjct: 314 LEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQ 372 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPF---------EHDEEIIRGQVFFRQRVSSECQH 265 + SA +SLG +L+ ++ G PF E D + V S E + Sbjct: 373 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 432 Query: 266 LIRWCLALRPSDRP-----TFEEIQNHPWMQDVLLPQETAEIHLHSLSP 309 L+ L + R +E++ P+ + + + + L P Sbjct: 433 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIP 481 >6HXF-B nrPDB Length = 302 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 60/272 (22%), Positives = 110/272 (40%), Gaps = 26/272 (9%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 +++ LG G FG VY A K +E + + +E+ +L Sbjct: 21 WEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDY------IVEIEILATCD 74 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 + +++LL + +++E + L E + Q+LEA+ Sbjct: 75 HPY--IVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNF 132 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT--DFDGTRVYSPPEWIRY 215 H+ ++HRD+K N+L+ L G+++L DFG A T+ F GT + PE + Sbjct: 133 LHSKRIIHRDLKAGNVLMTLE-GDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMC 191 Query: 216 HRY----HGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRG----------QVFFRQRVSS 261 + A +WSLGI L +M + P H+ +R + + S Sbjct: 192 ETMKDTPYDYKADIWSLGITLIEMAQIEPP-HHELNPMRVLLKIAKSDPPTLLTPSKWSV 250 Query: 262 ECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 E + ++ L P RP+ ++ HP++ + Sbjct: 251 EFRDFLKIALDKNPETRPSAAQLLEHPFVSSI 282 >3PPZ-A nrPDB Length = 309 Score = 215 bits (548), Expect = 2e-56, Method: Composition-based stats. Identities = 57/302 (18%), Positives = 121/302 (40%), Gaps = 28/302 (9%) Query: 18 NDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDW 77 +L+ G + + + +G+G FG+V+ VA+K + + Sbjct: 19 ENLYFQGAMDGDDMDIPWCDLNIKEKIGAGSFGTVHRAEWH--GSDVAVKIL----MEQD 72 Query: 78 GELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG 137 EV ++K++ ++ + +P + ++ E L+ + + G Sbjct: 73 FHAERVNEFLREVAIMKRLRH--PNIVLFMGAVTQPPNLSIVTEYLS-RGSLYRLLHKSG 129 Query: 138 A---LQEELARSFFWQVLEAVRHCHNCG--VLHRDIKDENILIDLNRGELKLIDFGSGAL 192 A L E S + V + + + HN ++HRD+K N+L+D +K+ DFG L Sbjct: 130 AREQLDERRRLSMAYDVAKGMNYLHNRNPPIVHRDLKSPNLLVDKKY-TVKVCDFGLSRL 188 Query: 193 LKDTVY--TDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE--- 247 T GT + PE +R + +S V+S G++L+++ P+ + Sbjct: 189 KASTFLSSKSAAGTPEWMAPEVLRDEPSNEKS-DVYSFGVILWELATLQQPWGNLNPAQV 247 Query: 248 -----IIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQN--HPWMQDVLLPQETA 300 ++ + ++ + +I C P RP+F I + P ++ + P + Sbjct: 248 VAAVGFKCKRLEIPRNLNPQVAAIIEGCWTNEPWKRPSFATIMDLLRPLIKSAVPPPNRS 307 Query: 301 EI 302 ++ Sbjct: 308 DL 309 >1UA2-A nrPDB Length = 346 Score = 215 bits (547), Expect = 3e-56, Method: Composition-based stats. Identities = 70/295 (23%), Positives = 116/295 (39%), Gaps = 45/295 (15%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +Y+ LG G F +VY + N VAIK ++ S+ + N T E+ LL++ Sbjct: 10 KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRT-ALREIKLLQE 68 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQVLEA 154 +S +I LLD F + L+ + E DL I + L +++ L+ Sbjct: 69 LSH--PNIIGLLDAFGHKSNISLVFDFMET--DLEVIIKDNSLVLTPSHIKAYMLMTLQG 124 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPEW 212 + + H +LHRD+K N+L+D N G LKL DFG + YT TR Y PE Sbjct: 125 LEYLHQHWILHRDLKPNNLLLDEN-GVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPEL 183 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPF-EHDEEIIRGQVFF-----------RQRVS 260 + R +G +W++G +L +++ +PF D ++ + F S Sbjct: 184 LFGARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCS 242 Query: 261 -----------------------SECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 + LI+ P R T + + + Sbjct: 243 LPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSN 297 >6GQK-A nrPDB Length = 328 Score = 214 bits (546), Expect = 3e-56, Method: Composition-based stats. Identities = 66/302 (21%), Positives = 120/302 (39%), Gaps = 43/302 (14%) Query: 20 LHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSG-----IRVSDNLPVAIKHVEKDRI 74 + T+L + E ++ G LG+G FG V I+ + VA+K ++ Sbjct: 25 IDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAQGLIKSDAAMTVAVKMLKPSAH 84 Query: 75 SDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT 134 S E + E+ +L + + ++ LL ++I E DL +F+ Sbjct: 85 STEREA-----LMSELKVLSYLGN-HENIVNLLGACTHGGPTLVITEYCC-YGDLLNFLR 137 Query: 135 ERG----------------ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLN 178 + L E SF +QV + + + +HRD+ NIL+ Sbjct: 138 RKRDEFVPYKVAPEDLYKDFLTLEHLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHG 197 Query: 179 RGELKLIDFGSGALLK-DTVYTDFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYD 234 K+ DFG +K D+ Y D R+ + PE I ++ + + VWS GI L++ Sbjct: 198 -NITKICDFGLARDIKNDSNYVDKGNARLPVKWMAPESI-FNSVYTFESDVWSYGIFLWE 255 Query: 235 MVC-GDIPFEH---DEEIIRG-----QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQ 285 + G P+ D + + ++ + +E +++ C P RPTF++I Sbjct: 256 LFSLGSSPYPGMPVDSKFYKMIKEGFRMSSPEYAPAEMYDIMKTCWDADPDKRPTFKQIV 315 Query: 286 NH 287 Sbjct: 316 QD 317 >3PVW-A nrPDB Length = 695 Score = 214 bits (546), Expect = 4e-56, Method: Composition-based stats. Identities = 69/289 (23%), Positives = 119/289 (41%), Gaps = 20/289 (6%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 + + V ++G GGFG VY + A+K ++K RI T E ++L Sbjct: 189 NDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQ---GETLALNERIMLSL 245 Query: 96 VSSGF-SGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 VS+G ++ + F PD IL+ DL +++ G E R + +++ Sbjct: 246 VSTGDCPFIVCMSYAFHTPDKLSFILDLMNG-GDLHYHLSQHGVFSEADMRFYAAEIILG 304 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIR 214 + H HN V++RD+K NIL+D G +++ D G GT Y PE ++ Sbjct: 305 LEHMHNRFVVYRDLKPANILLD-EHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQ 363 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPF---------EHDEEIIRGQVFFRQRVSSECQH 265 + SA +SLG +L+ ++ G PF E D + V S E + Sbjct: 364 KGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRS 423 Query: 266 LIRWCLALRPSDRP-----TFEEIQNHPWMQDVLLPQETAEIHLHSLSP 309 L+ L + R +E++ P+ + + + + L P Sbjct: 424 LLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIP 472 >3TKU-A nrPDB Length = 433 Score = 214 bits (545), Expect = 5e-56, Method: Composition-based stats. Identities = 67/304 (22%), Positives = 124/304 (40%), Gaps = 32/304 (10%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 KE + +++ ++G G FG V + A+K + K + E R Sbjct: 83 KEMQLHREDFEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACF-REER 141 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSF 147 +V++ + L F+ + L+++ DL +++ L E++AR + Sbjct: 142 DVLVNGDCQW----ITALHYAFQDENHLYLVMDYYVG-GDLLTLLSKFEDKLPEDMARFY 196 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT---VYTDFDGT 204 +++ A+ H +HRDIK +N+L+D+N G ++L DFGS + D + GT Sbjct: 197 IGEMVLAIDSIHQLHYVHRDIKPDNVLLDVN-GHIRLADFGSCLKMNDDGTVQSSVAVGT 255 Query: 205 RVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEII--------RGQ 252 Y PE ++ +G WSLG+ +Y+M+ G+ PF + + + Sbjct: 256 PDYISPEILQAMEDGMGKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEER 315 Query: 253 VFFRQR---VSSECQHLIRWCLALRPSDRP---TFEEIQNHPWMQDVLLPQETAEIHLHS 306 F VS E + LI+ + R R E+ + H + + + E Sbjct: 316 FQFPSHVTDVSEEAKDLIQRLICSR-ERRLGQNGIEDFKKHAFFEGLNW--ENIRNLEAP 372 Query: 307 LSPG 310 P Sbjct: 373 YIPD 376 >3HKO-A nrPDB Length = 345 Score = 213 bits (544), Expect = 6e-56, Method: Composition-based stats. Identities = 73/323 (22%), Positives = 120/323 (37%), Gaps = 60/323 (18%) Query: 27 PGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRV 86 G L+ +Y + +G G +G V I AIK + K++I + R+ Sbjct: 17 QGGSLLELQKKYHLKGAIGQGSYGVVRVAIENQTRAIRAIKIMNKNKIRQI-NPKDVERI 75 Query: 87 PMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDL---------------FD 131 EV L+KK+ + RL + +E L++E L D Sbjct: 76 KTEVRLMKKLHH--PNIARLYEVYEDEQYICLVMELCHGGHLLDKLNVFIDDSTGKCAMD 133 Query: 132 FITE--------------------RGALQ----EELARSFFWQVLEAVRHCHNCGVLHRD 167 + R +L E+L + Q+ A+ + HN G+ HRD Sbjct: 134 VVKTQICPCPECNEEAINGSIHGFRESLDFVQREKLISNIMRQIFSALHYLHNQGICHRD 193 Query: 168 IKDENILIDLNRG-ELKLIDFGSGALL----KDTVY--TDFDGTRVYSPPEWIR-YHRYH 219 IK EN L N+ E+KL+DFG Y T GT + PE + + + Sbjct: 194 IKPENFLFSTNKSFEIKLVDFGLSKEFYKLNNGEYYGMTTKAGTPYFVAPEVLNTTNESY 253 Query: 220 GRSAAVWSLGILLYDMVCGDIPFEH------DEEIIRGQVFFRQR----VSSECQHLIRW 269 G WS G+LL+ ++ G +PF +++ ++ F +S + L+ Sbjct: 254 GPKCDAWSAGVLLHLLLMGAVPFPGVNDADTISQVLNKKLCFENPNYNVLSPLARDLLSN 313 Query: 270 CLALRPSDRPTFEEIQNHPWMQD 292 L +R HPW+ Sbjct: 314 LLNRNVDERFDAMRALQHPWISQ 336 >5AWM-A nrPDB Length = 394 Score = 213 bits (544), Expect = 6e-56, Method: Composition-based stats. Identities = 73/340 (21%), Positives = 130/340 (38%), Gaps = 73/340 (21%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 G + S+Y +GSG G V + VAIK + + + + + R Sbjct: 36 GDTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP----FQNVTHAKRAY 91 Query: 88 MEVVLLKKVSSGFSGVIRLLDWF------ERPDSFVLILERPEPVQDLFDFITERGALQE 141 E L+K V+ +I LL+ F E L++E + +L I L Sbjct: 92 REFKLMKLVNH--KNIIGLLNAFTPQRNLEEFQDVYLVMELMDA--NLCQVIQMD--LDH 145 Query: 142 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-VYTD 200 + +Q+L ++H H+ G++HRD+K NI++ + LK++DFG T + T Sbjct: 146 DRMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKAD-CTLKILDFGLARTAGTTFMMTP 204 Query: 201 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEI------------ 248 + TR Y PE I Y + +WS+G ++ +M+ G + F + I Sbjct: 205 YVVTRYYRAPEVILGMGY-TENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGT 263 Query: 249 ------------IRGQVFFRQRVS-------------------------SECQHLIRWCL 271 +R V R R + S+ ++L+ L Sbjct: 264 PSPSFMQRLQPTVRNYVENRPRYTGYSFDRLFPDGLFPNDNNQNSRRKASDARNLLSKML 323 Query: 272 ALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGP 311 + P R + +E H ++ +E + + +P P Sbjct: 324 VIDPEQRISVDEALKHEYINVWYDAEE-----VDAPAPEP 358 >3LM0-A nrPDB Length = 327 Score = 213 bits (542), Expect = 9e-56, Method: Composition-based stats. Identities = 71/302 (23%), Positives = 120/302 (39%), Gaps = 28/302 (9%) Query: 22 ATKLAPGKEKEPLESQYQV-GPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGEL 80 T+ + E + Y + LG G F V I S A K ++K R Sbjct: 14 GTENLYFQSMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQD--- 70 Query: 81 PNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI--TERGA 138 + E+ +L+ S VI L + +E +LILE ++F Sbjct: 71 -CRAEILHEIAVLELAKSC-PRVINLHEVYENTSEIILILEYAAG-GEIFSLCLPELAEM 127 Query: 139 LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDL--NRGELKLIDFGSGALLKDT 196 + E Q+LE V + H ++H D+K +NIL+ G++K++DFG + Sbjct: 128 VSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHA 187 Query: 197 -VYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EII 249 + GT Y PE + Y + +W++GI+ Y ++ PF ++ I Sbjct: 188 CELREIMGTPEYLAPEILNYDPITT-ATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNIS 246 Query: 250 RGQVFFRQR----VSSECQHLIRWCLALRPSDRPTFEEIQNHPW-----MQDVLLPQETA 300 + V + + VS I+ L P RPT E +H W +++ P+ET+ Sbjct: 247 QVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETS 306 Query: 301 EI 302 Sbjct: 307 SS 308 >4UYA-A nrPDB Length = 340 Score = 212 bits (541), Expect = 1e-55, Method: Composition-based stats. Identities = 57/278 (20%), Positives = 102/278 (36%), Gaps = 27/278 (9%) Query: 27 PGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRV 86 G + ++ L+G+GGFG VY VA+K +D D R Sbjct: 17 QGSPVHVAFERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAESVR- 73 Query: 87 PMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARS 146 E L + +I L + L+LE + + + + Sbjct: 74 -REARLFAMLRH--PNIIELRGVCLQQPHLCLVLEFARGGA--LNRALAGRRIPPHVLVN 128 Query: 147 FFWQVLEAVRHCHNCG---VLHRDIKDENILI-------DLNRGELKLIDFGSGALLKDT 196 + Q+ + + H +LHRD+K NIL+ D+ LK+ DFG T Sbjct: 129 WAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRT 188 Query: 197 VYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE--------EI 248 G + PE I+ + + + +WS G+LL++++ G++P+ + + Sbjct: 189 TKMATAGAYAWMAPEVIKSSLF-SKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAV 247 Query: 249 IRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 + + L++ C P RP+F I Sbjct: 248 NKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILE 285 >2OGV-A nrPDB Length = 317 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 63/293 (21%), Positives = 116/293 (39%), Gaps = 37/293 (12%) Query: 20 LHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLP-----VAIKHVEKDRI 74 + T+L ++ E + Q G LG+G FG V VA+K ++ Sbjct: 22 IDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAH 81 Query: 75 SDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT 134 +D E + E+ ++ + ++ LL ++I E DL +F+ Sbjct: 82 ADEKEA-----LMSELKIMSHLG-QHENIVNLLGACTHGGPVLVITEYCC-YGDLLNFLR 134 Query: 135 ER----------GALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKL 184 + L+ F QV + + + +HRD+ N+L+ N K+ Sbjct: 135 RKAEADLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLT-NGHVAKI 193 Query: 185 IDFGSGA-LLKDTVYTDFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GD 239 DFG ++ D+ Y R+ + PE I + + + VWS GILL+++ G Sbjct: 194 GDFGLARDIMNDSNYIVKGNARLPVKWMAPESI-FDCVYTVQSDVWSYGILLWEIFSLGL 252 Query: 240 IPFEH---DEEIIRG-----QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEI 284 P+ + + + Q+ +++ C AL P+ RPTF++I Sbjct: 253 NPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 305 >2H8H-A nrPDB Length = 535 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 68/281 (24%), Positives = 113/281 (40%), Gaps = 29/281 (10%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 E ++ LG G FG V+ G VAIK ++ +S E Sbjct: 262 WEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEA-------FLQEA 313 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER--GALQEELARSFF 148 ++KK+ +++L ++ E L DF+ L+ Sbjct: 314 QVMKKLRH--EKLVQLYAVVSEEP-IYIVTEYMSK-GSLLDFLKGETGKYLRLPQLVDMA 369 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV-- 206 Q+ + + +HRD++ NIL+ N K+ DFG L++D YT G + Sbjct: 370 AQIASGMAYVERMNYVHRDLRAANILVGENL-VCKVADFGLARLIEDNEYTARQGAKFPI 428 Query: 207 -YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH---DEEIIRGQVFFRQRVSS 261 ++ PE Y R+ +S VWS GILL ++ G +P+ E + + + +R Sbjct: 429 KWTAPEAALYGRFTIKS-DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP 487 Query: 262 EC----QHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQE 298 EC L+ C P +RPTFE +Q +++D E Sbjct: 488 ECPESLHDLMCQCWRKEPEERPTFEYLQA--FLEDYFTSTE 526 >3BEA-A nrPDB Length = 333 Score = 212 bits (540), Expect = 2e-55, Method: Composition-based stats. Identities = 63/297 (21%), Positives = 115/297 (38%), Gaps = 41/297 (13%) Query: 20 LHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLP-----VAIKHVEKDRI 74 + T+L ++ E + Q G LG+G FG V VA+K ++ Sbjct: 30 IDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAH 89 Query: 75 SDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT 134 +D E + E+ ++ + ++ LL ++I E DL +F+ Sbjct: 90 ADEKEA-----LMSELKIMSHLG-QHENIVNLLGACTHGGPVLVITEYCC-YGDLLNFLR 142 Query: 135 ERGA--------------LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG 180 + L F QV + + + +HRD+ N+L+ N Sbjct: 143 RKSRVLETDPAFAIANSTLSTRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLT-NGH 201 Query: 181 ELKLIDFGSGA-LLKDTVYTDFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMV 236 K+ DFG ++ D+ Y R+ + PE I + + + VWS GILL+++ Sbjct: 202 VAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESI-FDCVYTVQSDVWSYGILLWEIF 260 Query: 237 C-GDIPFEH---DEEIIRG-----QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEI 284 G P+ + + + Q+ +++ C AL P+ RPTF++I Sbjct: 261 SLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 317 >6F3F-A nrPDB Length = 455 Score = 212 bits (539), Expect = 2e-55, Method: Composition-based stats. Identities = 68/281 (24%), Positives = 113/281 (40%), Gaps = 29/281 (10%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 E ++ LG G FG V+ G VAIK ++ +S E Sbjct: 182 WEIPRESLRLEVKLGQGCFGEVWMGTWNGT-TRVAIKTLKPGTMSPEA-------FLQEA 233 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER--GALQEELARSFF 148 ++KK+ +++L ++ E L DF+ L+ Sbjct: 234 QVMKKLRH--EKLVQLYAVVSEEP-IYIVTEYMNK-GSLLDFLKGETGKYLRLPQLVDMS 289 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV-- 206 Q+ + + +HRD++ NIL+ N K+ DFG L++D YT G + Sbjct: 290 AQIASGMAYVERMNYVHRDLRAANILVGENL-VCKVADFGLARLIEDNEYTARQGAKFPI 348 Query: 207 -YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH---DEEIIRGQVFFRQRVSS 261 ++ PE Y R+ +S VWS GILL ++ G +P+ E + + + +R Sbjct: 349 KWTAPEAALYGRFTIKS-DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP 407 Query: 262 EC----QHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQE 298 EC L+ C P +RPTFE +Q +++D E Sbjct: 408 ECPESLHDLMCQCWRKEPEERPTFEYLQA--FLEDYFTSTE 446 >6CQF-A nrPDB Length = 297 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 61/274 (22%), Positives = 105/274 (38%), Gaps = 27/274 (9%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 Y + LG G +G V+ VA+K V+ + D L E+++LK Sbjct: 15 RDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVSTLQK------EILILK 68 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 ++ + + +E L D G+L E +VL+ Sbjct: 69 TCRHA--NIVAYHGSYLWLQKLWICMEFC-GAGSLQDIYQVTGSLSELQISYVCREVLQG 125 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT--DFDGTRVYSPPEW 212 + + H+ +HRDIK NILI+ + GE++L DFG A + T+ F GT + PE Sbjct: 126 LAYLHSQKKIHRDIKGANILIN-DAGEVRLADFGISAQIGATLARRLAFIGTPYWMAPEV 184 Query: 213 --IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ------------R 258 + + +WSLGI ++ P D +R + + Sbjct: 185 AAVALKGGYNELCDIWSLGITAIELAELQPPLF-DVHPLRVLFLMTKSGYQPPRLKEKGK 243 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 S+ + I+ L P RP+ ++ +H + Sbjct: 244 WSAAFHNFIKVTLTKSPKKRPSATKMLSHQLVSQ 277 >3ZDU-A nrPDB Length = 325 Score = 211 bits (538), Expect = 3e-55, Method: Composition-based stats. Identities = 64/304 (21%), Positives = 119/304 (39%), Gaps = 52/304 (17%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 Y+ +G G +G+V + VAIK + E E+ LK+ Sbjct: 3 EMYETLGKVGEGSYGTVMKCKHKNTGQIVAIKI-----FYERPEQSVNKIAMREIKFLKQ 57 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEP--VQDLFDFITERGALQEELARSFFWQVLE 153 ++ L++ F + L+ E + + +L + L+ + R + +Q+L Sbjct: 58 FHH--ENLVNLIEVFRQKKKIHLVFEFIDHTVLDELQHYCH---GLESKRLRKYLFQILR 112 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPE 211 A+ + H+ ++HRDIK ENIL+ + G KL DFG L +Y D TR Y PE Sbjct: 113 AIDYLHSNNIIHRDIKPENILVSQS-GITKLCDFGFARTLAAPGDIYDDEVATRWYRAPE 171 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDI--PFEHDEEIIRGQVFFRQRVSSECQ----- 264 + +G+ +W+LG ++ +M G+ P D +++ V +S Q Sbjct: 172 LVLKDTSYGKPVDIWALGCMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSK 231 Query: 265 ------------------------------HLIRWCLALRPSDRPTFEEIQNHPWMQDVL 294 ++ CL + P+DR + ++ +H + Sbjct: 232 SPIFAGVVLPQVQHPKNARKKYPKLNGLLADIVHACLQIDPADRISSSDLLHHEYFTRDG 291 Query: 295 LPQE 298 ++ Sbjct: 292 FIEK 295 >1U5R-A nrPDB Length = 348 Score = 210 bits (536), Expect = 4e-55, Method: Composition-based stats. Identities = 66/272 (24%), Positives = 110/272 (40%), Gaps = 23/272 (8%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 K+ E + +G G FG+VY V ++ VAIK + + + + EV Sbjct: 49 KDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQD---IIKEV 105 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITERGALQEELARSFFW 149 L+K+ I+ + R + L++E DL + + LQE + Sbjct: 106 RFLQKLRH--PNTIQYRGCYLREHTAWLVMEYCLGSASDLLEV--HKKPLQEVEIAAVTH 161 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSP 209 L+ + + H+ ++HRD+K NIL+ G +KL DFGS +++ F GT + Sbjct: 162 GALQGLAYLHSHNMIHRDVKAGNILLS-EPGLVKLGDFGSASIMA--PANSFVGTPYWMA 218 Query: 210 PEWI--RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ---------R 258 PE I + VWSLGI ++ P + + Q Sbjct: 219 PEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPALQSGH 277 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 S ++ + CL P DRPT E + H ++ Sbjct: 278 WSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFV 309 >5O2C-A nrPDB Length = 380 Score = 210 bits (535), Expect = 6e-55, Method: Composition-based stats. Identities = 59/282 (20%), Positives = 124/282 (43%), Gaps = 25/282 (8%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 ++ + LG G F +VY G+ + VA ++ +++ + R E +LK + Sbjct: 28 KFDIE--LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ----QRFKEEAEMLKGL 81 Query: 97 SSGFSGVIRLLDWFE---RPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 ++R D +E + ++++ L ++ ++ ++ RS+ Q+L+ Sbjct: 82 QH--PNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILK 139 Query: 154 AVRHCHNC--GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPE 211 ++ H ++HRD+K +NI I G +K+ D G L++ + GT + PE Sbjct: 140 GLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPE 199 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPF---EHDEEIIR------GQVFFRQRVSSE 262 Y ++ S V++ G+ + +M + P+ ++ +I R F + E Sbjct: 200 --MYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPE 257 Query: 263 CQHLIRWCLALRPSDRPTFEEIQNHPWM-QDVLLPQETAEIH 303 + +I C+ S+R + ++ NH + +D L E AE Sbjct: 258 VKEIIEGCIRQNKSERLSIRDLLNHAFFAEDTGLRVELAEED 299 >6GVJ-A nrPDB Length = 429 Score = 210 bits (535), Expect = 6e-55, Method: Composition-based stats. Identities = 75/310 (24%), Positives = 125/310 (40%), Gaps = 33/310 (10%) Query: 11 HLRAAPCNDLHATKLAPGKEKEPLESQ-YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHV 69 + A P +L + E ++ + Y + +GSGG V+ + AIK+V Sbjct: 118 QILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQVLNEK-KQIYAIKYV 176 Query: 70 EKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDL 129 + + E+ L K+ +IRL D+ +++E DL Sbjct: 177 NLEEADNQTLDSYRN----EIAYLNKLQQHSDKIIRLYDYEITDQYIYMVME--CGNIDL 230 Query: 130 FDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGS 189 ++ ++ ++ +S++ +LEAV H G++H D+K N LI G LKLIDFG Sbjct: 231 NSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIV--DGMLKLIDFGI 288 Query: 190 GALLKDTVYT----DFDGTRVYSPPEWIRYHRYH----------GRSAAVWSLGILLYDM 235 ++ + GT Y PPE I+ + VWSLG +LY M Sbjct: 289 ANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYM 348 Query: 236 VCGDIPFEHDEEIIRG---------QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 G PF+ I ++ F + Q +++ CL P R + E+ Sbjct: 349 TYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLA 408 Query: 287 HPWMQDVLLP 296 HP++Q P Sbjct: 409 HPYVQIQTHP 418 >4AW2-A nrPDB Length = 437 Score = 210 bits (535), Expect = 6e-55, Method: Composition-based stats. Identities = 70/287 (24%), Positives = 127/287 (44%), Gaps = 30/287 (10%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 K+ +++ ++G G FG V + + A+K + K + E Sbjct: 67 KQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFRE--- 123 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSF 147 E +L V+ + L F+ ++ L+++ DL +++ L EE+AR + Sbjct: 124 ERDVL--VNGDSKWITTLHYAFQDDNNLYLVMDYYVG-GDLLTLLSKFEDRLPEEMARFY 180 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSG-ALLKDTV--YTDFDGT 204 +++ A+ H +HRDIK +NIL+D+N G ++L DFGS L++D + GT Sbjct: 181 LAEMVIAIDSVHQLHYVHRDIKPDNILMDMN-GHIRLADFGSCLKLMEDGTVQSSVAVGT 239 Query: 205 RVYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EIIRGQVF 254 Y PE ++ +G WSLG+ +Y+M+ G+ PF + +I+ + Sbjct: 240 PDYISPEILQAMEGGKGRYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKER 299 Query: 255 FRQR-----VSSECQHLIRWCLALRPSDRP---TFEEIQNHPWMQDV 293 F+ VS + LIR + R R E+ + HP+ + Sbjct: 300 FQFPTQVTDVSENAKDLIRRLICSR-EHRLGQNGIEDFKKHPFFSGI 345 >3KRL-A nrPDB Length = 335 Score = 210 bits (534), Expect = 7e-55, Method: Composition-based stats. Identities = 63/299 (21%), Positives = 115/299 (38%), Gaps = 43/299 (14%) Query: 20 LHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLP-----VAIKHVEKDRI 74 + T+L ++ E + Q G LG+G FG V VA+K ++ Sbjct: 30 IDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAH 89 Query: 75 SDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT 134 +D E + E+ ++ + ++ LL ++I E DL +F+ Sbjct: 90 ADEKEA-----LMSELKIMSHLG-QHENIVNLLGACTHGGPVLVITEYCC-YGDLLNFLR 142 Query: 135 ERGA----------------LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLN 178 + L F QV + + + +HRD+ N+L+ N Sbjct: 143 RKRPPGLEYSYNPSHNPEEQLSSRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLT-N 201 Query: 179 RGELKLIDFGSGA-LLKDTVYTDFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYD 234 K+ DFG ++ D+ Y R+ + PE I + + + VWS GILL++ Sbjct: 202 GHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESI-FDCVYTVQSDVWSYGILLWE 260 Query: 235 MVC-GDIPFEH---DEEIIRG-----QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEI 284 + G P+ + + + Q+ +++ C AL P+ RPTF++I Sbjct: 261 IFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQI 319 >3QGY-A nrPDB Length = 286 Score = 210 bits (534), Expect = 8e-55, Method: Composition-based stats. Identities = 69/263 (26%), Positives = 119/263 (45%), Gaps = 25/263 (9%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 S+ +GSG FG V+ G + + VAIK +++ +S+ + E ++ K Sbjct: 27 SELTFVQEIGSGQFGLVHLGYWL-NKDKVAIKTIKEGSMSEDDFIE-------EAEVMMK 78 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT-ERGALQEELARSFFWQVLEA 154 +S +++L L+ E E L D++ +RG E V E Sbjct: 79 LSH--PKLVQLYGVCLEQAPICLVFEFME-HGCLSDYLRTQRGLFAAETLLGMCLDVCEG 135 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---YSPPE 211 + + V+HRD+ N L+ N+ +K+ DFG + D YT GT+ ++ PE Sbjct: 136 MAYLEEACVIHRDLAARNCLVGENQ-VIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPE 194 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHD------EEIIRGQVFFRQRV-SSEC 263 + RY +S VWS G+L++++ G IP+E+ E+I G ++ R+ S+ Sbjct: 195 VFSFSRYSSKS-DVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHV 253 Query: 264 QHLIRWCLALRPSDRPTFEEIQN 286 ++ C RP DRP F + Sbjct: 254 YQIMNHCWKERPEDRPAFSRLLR 276 >3E7O-A nrPDB Length = 360 Score = 210 bits (534), Expect = 8e-55, Method: Composition-based stats. Identities = 70/318 (22%), Positives = 124/318 (38%), Gaps = 67/318 (21%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +YQ +GSG G V + + VA+K + + + + R E+VLLK Sbjct: 22 KRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP----FQNQTHAKRAYRELVLLKC 77 Query: 96 VSSGFSGVIRLLDWF------ERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 V+ +I LL+ F E L++E + +L I L E + Sbjct: 78 VNH--KNIISLLNVFTPQKTLEEFQDVYLVMELMDA--NLCQVIHME--LDHERMSYLLY 131 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-VYTDFDGTRVYS 208 Q+L ++H H+ G++HRD+K NI++ + LK++DFG + T + TR Y Sbjct: 132 QMLCGIKHLHSAGIIHRDLKPSNIVVKSD-CTLKILDFGLARTASTNFMMTPYVVTRYYR 190 Query: 209 PPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRG----------------- 251 PE I Y + +WS+G ++ ++V G + F+ + I + Sbjct: 191 APEVILGMGYK-ENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSAEFMAA 249 Query: 252 --------------------QVFFRQRV-----------SSECQHLIRWCLALRPSDRPT 280 + F + +S+ + L+ L + P R + Sbjct: 250 LQPTVRNYVENRPAYPGIAFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRIS 309 Query: 281 FEEIQNHPWMQDVLLPQE 298 +E HP++ P E Sbjct: 310 VDEALRHPYITVWYDPAE 327 >2GCD-A nrPDB Length = 309 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 66/272 (24%), Positives = 110/272 (40%), Gaps = 23/272 (8%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 K+ E + +G G FG+VY V ++ VAIK + + + + EV Sbjct: 10 KDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSYSGKQSNEKWQD---IIKEV 66 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITERGALQEELARSFFW 149 L+K+ I+ + R + L++E DL + + LQE + Sbjct: 67 RFLQKLRH--PNTIQYRGCYLREHTAWLVMEYCLGSASDLLEV--HKKPLQEVEIAAVTH 122 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSP 209 L+ + + H+ ++HRD+K NIL+ G +KL DFGS +++ F GT + Sbjct: 123 GALQGLAYLHSHNMIHRDVKAGNILLS-EPGLVKLGDFGSASIMA--PANSFVGTPYWMA 179 Query: 210 PEWI--RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ---------R 258 PE I + VWSLGI ++ P + + Q Sbjct: 180 PEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLF-NMNAMSALYHIAQNESPALQSGH 238 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 S ++ + CL P DRPT E + H ++ Sbjct: 239 WSEYFRNFVDSCLQKIPQDRPTSEVLLKHRFV 270 >4E7W-A nrPDB Length = 394 Score = 209 bits (533), Expect = 1e-54, Method: Composition-based stats. Identities = 77/330 (23%), Positives = 127/330 (38%), Gaps = 61/330 (18%) Query: 26 APGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTR 85 + GK E E Y ++G+G FG V+ V + VAIK V +D+ Sbjct: 30 SDGKTGEQREIAYTNCKVIGNGSFGVVFQAKLVESDE-VAIKKVLQDKRFK--------- 79 Query: 86 VPMEVVLLKKVSSGFSGVIRLLDWFERPDS------FVLILERP--EPVQDLFDFITERG 137 E+ +++ V V+ L +F L+LE + + + Sbjct: 80 -NRELQIMRIVKH--PNVVDLKAFFYSNGDKKDEVFLNLVLEYVPETVYRASRHYAKLKQ 136 Query: 138 ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL-KDT 196 + L + + +Q+L ++ + H+ G+ HRDIK +N+L+D G LKLIDFGS +L Sbjct: 137 TMPMLLIKLYMYQLLRSLAYIHSIGICHRDIKPQNLLLDPPSGVLKLIDFGSAKILIAGE 196 Query: 197 VYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EIIR 250 + +R Y PE I + + +WS G ++ +++ G F + EII+ Sbjct: 197 PNVSYICSRYYRAPELIFGATNYTTNIDIWSTGCVMAELMQGQPLFPGESGIDQLVEIIK 256 Query: 251 G-----------------------------QVFFRQRVSSECQHLIRWCLALRPSDRPTF 281 FR R + LI L PS R T Sbjct: 257 VLGTPSREQIKTMNPNYMEHKFPQIRPHPFSKVFRPRTPPDAIDLISRLLEYTPSARLTA 316 Query: 282 EEIQNHPWMQDVLLPQETAEIHLHSLSPGP 311 E HP+ ++ T E + + P Sbjct: 317 IEALCHPFFDEL----RTGEARMPNGRELP 342 >4EBW-A nrPDB Length = 304 Score = 209 bits (532), Expect = 1e-54, Method: Composition-based stats. Identities = 60/272 (22%), Positives = 118/272 (43%), Gaps = 26/272 (9%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDN---LPVAIKHVEKDRISDWGELPNGTR 85 ++ E + ++G +G G FG V+ GI +S L VAIK + E + Sbjct: 31 RDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVRE-----K 85 Query: 86 VPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT-ERGALQEELA 144 E + +++ +++L+ + +I+E + +L F+ + +L Sbjct: 86 FLQEALTMRQFDH--PHIVKLIGVI-TENPVWIIMELCT-LGELRSFLQVRKYSLDLASL 141 Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGT 204 + +Q+ A+ + + +HRDI N+L+ N +KL DFG ++D+ Y Sbjct: 142 ILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDC-VKLGDFGLSRYMEDSTYYKASKG 200 Query: 205 RV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEE------IIRGQVF 254 ++ + PE I + R+ ++ VW G+ +++++ G PF+ + I G+ Sbjct: 201 KLPIKWMAPESINFRRFTS-ASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERL 259 Query: 255 -FRQRVSSECQHLIRWCLALRPSDRPTFEEIQ 285 L+ C A PS RP F E++ Sbjct: 260 PMPPNCPPTLYSLMTKCWAYDPSRRPRFTELK 291 >4O2Z-A nrPDB Length = 377 Score = 208 bits (531), Expect = 2e-54, Method: Composition-based stats. Identities = 64/310 (20%), Positives = 123/310 (39%), Gaps = 45/310 (14%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 S+Y + +LG G +G S + V+IK + ++ +G RV E+ +++ Sbjct: 45 SKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCRD----VFRDVEDGKRVLREIDMMRF 100 Query: 96 VSS-GFSGVIRLLDWFERPDSFVLILERPEPVQD--LFDFITERGALQEELARSFFWQVL 152 V+ +L +R + P+ D + + R L+E + F +Q+L Sbjct: 101 FHHENLLNVVNILPPLKREYHSFEDVYVVTPLMDVDMNVVLRSRQVLEESHMQYFVYQIL 160 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPP 210 +++ H+ V HRD+K N++ +++ ELK+IDFG + + TD+ TR Y PP Sbjct: 161 RGLKYLHSANVAHRDLKPANLVTNIS-CELKIIDFGLSRSVDVPYSELTDYVITRWYRPP 219 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------------------------ 246 E + + + + +WS+G + +M F Sbjct: 220 ELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASIVEHRE 279 Query: 247 ------EIIRGQVFFRQRVS-----SECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLL 295 E+ G + + V +E + L PS RPT ++ HP++ + Sbjct: 280 ALEKLNELPDGSLNIPKLVPGLAGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHD 339 Query: 296 PQETAEIHLH 305 ++ Sbjct: 340 EEDEPTCPCP 349 >2DQ7-X nrPDB Length = 283 Score = 208 bits (530), Expect = 2e-54, Method: Composition-based stats. Identities = 74/281 (26%), Positives = 121/281 (43%), Gaps = 29/281 (10%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 E Q+ LG+G FG V+ G + N VAIK ++ +S L E Sbjct: 4 WEIPRESLQLIKRLGNGQFGEVWMGTW-NGNTKVAIKTLKPGTMSPESFLE-------EA 55 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT--ERGALQEELARSFF 148 ++KK+ +++L ++ E L DF+ E AL+ Sbjct: 56 QIMKKLKHDK--LVQLYAVVSEEP-IYIVTEYMNK-GSLLDFLKDGEGRALKLPNLVDMA 111 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV-- 206 QV + + +HRD++ NIL+ N K+ DFG L++D YT G + Sbjct: 112 AQVAAGMAYIERMNYIHRDLRSANILVG-NGLICKIADFGLARLIEDNEYTARQGAKFPI 170 Query: 207 -YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH---DEEIIRGQVFFRQRVSS 261 ++ PE Y R+ +S VWS GILL ++V G +P+ E + + + +R Sbjct: 171 KWTAPEAALYGRFTIKS-DVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQ 229 Query: 262 EC----QHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQE 298 +C L+ C P +RPTFE +Q+ +++D E Sbjct: 230 DCPISLHELMIHCWKKDPEERPTFEYLQS--FLEDYFTATE 268 >5O2B-A nrPDB Length = 285 Score = 208 bits (530), Expect = 2e-54, Method: Composition-based stats. Identities = 54/270 (20%), Positives = 119/270 (44%), Gaps = 24/270 (8%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 ++ + LG G F +VY G+ + VA ++ +++ + R E +LK + Sbjct: 19 KFDIE--LGRGAFKTVYKGLDTETWVEVAWCELQDRKLTKAEQ----QRFKEEAEMLKGL 72 Query: 97 SSGFSGVIRLLDWFE---RPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 ++R D +E + ++++ L ++ ++ ++ RS+ Q+L+ Sbjct: 73 QH--PNIVRFYDSWESILKGKKCIVLVTELMTSGTLKTYLKRFKVMKPKVLRSWCRQILK 130 Query: 154 AVRHCHNC--GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPE 211 ++ H ++HRD+K +NI I G +K+ D G L++ + GT + PE Sbjct: 131 GLQFLHTRTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLMRTSFAKSVIGTPEFMAPE 190 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPF---EHDEEIIR------GQVFFRQRVSSE 262 Y ++ S V++ G+ + +M + P+ ++ +I R F + E Sbjct: 191 --MYEEHYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRKVTSGIKPASFNKVTDPE 248 Query: 263 CQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 + +I C+ S+R + ++ NH + + Sbjct: 249 VKEIIEGCIRQNKSERLSIRDLLNHAFFAE 278 >2J0K-A nrPDB Length = 656 Score = 208 bits (529), Expect = 3e-54, Method: Composition-based stats. Identities = 59/287 (20%), Positives = 123/287 (42%), Gaps = 26/287 (9%) Query: 14 AAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDN---LPVAIKHVE 70 A ++ + ++ E + ++G +G G FG V+ GI +S + VAIK + Sbjct: 368 AEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPAMAVAIKTCK 427 Query: 71 KDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLF 130 E + E + +++ +++L+ + +I+E + +L Sbjct: 428 NCTSDSVRE-----KFLQEALTMRQFDH--PHIVKLIGVI-TENPVWIIMELCT-LGELR 478 Query: 131 DFIT-ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGS 189 F+ + +L + +Q+ A+ + + +HRDI N+L+ +KL DFG Sbjct: 479 SFLQVRKFSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSATDC-VKLGDFGL 537 Query: 190 GALLKDTVYTDFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH- 244 ++D+ Y ++ + PE I + R+ ++ VW G+ +++++ G PF+ Sbjct: 538 SRYMEDSTYYKASKGKLPIKWMAPESINFRRFTS-ASDVWMFGVCMWEILMHGVKPFQGV 596 Query: 245 --DEEIIRGQ----VFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQ 285 ++ I R + + L+ C A PS RP F E++ Sbjct: 597 KNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELK 643 >4CRS-A nrPDB Length = 341 Score = 207 bits (527), Expect = 5e-54, Method: Composition-based stats. Identities = 63/287 (21%), Positives = 121/287 (42%), Gaps = 21/287 (7%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 ++ +L G FG V + N AIK ++K I E+ + + E + + V Sbjct: 13 DFRCCAVLLRGHFGKVLLAEYKNTNEMFAIKALKKGDIVARDEVDS---LMCEKRIFETV 69 Query: 97 SS-GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 +S ++ L F+ + ++E DL I E A + V+ + Sbjct: 70 NSVRHPFLVNLFACFQTKEHVCFVMEYAAG-GDLMMHI-HTDVFSEPRAVFYAACVVLGL 127 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA--LLKDTVYTDFDGTRVYSPPEWI 213 ++ H +++RD+K + L+ G +K+ DFG + + F GT + PE + Sbjct: 128 QYLHEHKIVYRDLKLD-NLLLDTEGFVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVL 186 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQVFFRQRVSSECQHLI 267 + R+ W LG+L+Y+M+ G+ PF D+E I+ +V + + +S+E ++ Sbjct: 187 -TETSYTRAVDWWGLGVLIYEMLVGESPFPGDDEEEVFDSIVNDEVRYPRFLSTEAISIM 245 Query: 268 RWCLALRPSDRPT-----FEEIQNHPWMQDVLLPQETAEIHLHSLSP 309 R L P R E+++ HP+ + + + P Sbjct: 246 RRLLRRNPERRLGASEKDAEDVKKHPFFRLIDWSALMDKKVKPPFIP 292 >4BGQ-A nrPDB Length = 304 Score = 207 bits (526), Expect = 6e-54, Method: Composition-based stats. Identities = 70/301 (23%), Positives = 122/301 (40%), Gaps = 52/301 (17%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 + +++++ ++G G +G V + VAIK + E+ +L Sbjct: 10 VMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDS----EENEEVKETTLRELKML 65 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER-GALQEELARSFFWQVL 152 + + ++ L + F R L+ E E +++ + + E + E +S+ +Q++ Sbjct: 66 RTLK--QENIVELKEAFRRRGKLYLVFEYVE--KNMLELLEEMPNGVPPEKVKSYIYQLI 121 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL---KDTVYTDFDGTRVYSP 209 +A+ CH ++HRDIK EN+LI N LKL DFG L + Y + TR Y Sbjct: 122 KAIHWCHKNDIVHRDIKPENLLISHND-VLKLCDFGFARNLSEGNNANYDEEVATRWYRS 180 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIR---GQVFFRQRVSSECQ-- 264 PE + Y G+S +WS+G +L ++ G F + EI + Q S + + Sbjct: 181 PELLLGAPY-GKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLF 239 Query: 265 ---------------------------------HLIRWCLALRPSDRPTFEEIQNHPWMQ 291 L++ L L P+DR E+ NHP Q Sbjct: 240 YSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQ 299 Query: 292 D 292 Sbjct: 300 T 300 >1JNK-A nrPDB Length = 423 Score = 207 bits (526), Expect = 6e-54, Method: Composition-based stats. Identities = 70/326 (21%), Positives = 123/326 (37%), Gaps = 67/326 (20%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 G + +YQ +GSG G V + + VAIK + + + + R Sbjct: 54 GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP----FQNQTHAKRAY 109 Query: 88 MEVVLLKKVSSGFSGVIRLLDWF------ERPDSFVLILERPEPVQDLFDFITERGALQE 141 E+VL+K V+ +I LL+ F E L++E + +L I L Sbjct: 110 RELVLMKCVNH--KNIISLLNVFTPQKTLEEFQDVYLVMELMDA--NLCQVIQME--LDH 163 Query: 142 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-VYTD 200 E +Q+L ++H H+ G++HRD+K NI++ + LK++DFG + + T Sbjct: 164 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSD-CTLKILDFGLARTAGTSFMMTP 222 Query: 201 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQ-------- 252 + TR Y PE I Y + +WS+G ++ +MV I F + I + Sbjct: 223 YVVTRYYRAPEVILGMGYK-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGT 281 Query: 253 -------------------------VFFRQRVSSE---------------CQHLIRWCLA 272 + F + + L+ L Sbjct: 282 PCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLV 341 Query: 273 LRPSDRPTFEEIQNHPWMQDVLLPQE 298 + P+ R + ++ HP++ P E Sbjct: 342 IDPAKRISVDDALQHPYINVWYDPAE 367 >4R7H-A nrPDB Length = 343 Score = 207 bits (526), Expect = 7e-54, Method: Composition-based stats. Identities = 63/306 (20%), Positives = 116/306 (37%), Gaps = 50/306 (16%) Query: 20 LHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLP-----VAIKHVEKDRI 74 + T+L ++ E + Q G LG+G FG V VA+K ++ Sbjct: 34 IDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAH 93 Query: 75 SDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT 134 +D E + E+ ++ + ++ LL ++I E DL +F+ Sbjct: 94 ADEKEA-----LMSELKIMSHLG-QHENIVNLLGACTHGGPVLVITEYCT-YGDLLNFLR 146 Query: 135 ER-----------------------GALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDE 171 + L+ F QV + + + +HRD+ Sbjct: 147 RKAEAMLGPSLSPGQDPEGLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAAR 206 Query: 172 NILIDLNRGELKLIDFGSGA-LLKDTVYTDFDGTRV---YSPPEWIRYHRYHGRSAAVWS 227 N+L+ N K+ DFG ++ D+ Y R+ + PE I + + + VWS Sbjct: 207 NVLLT-NGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESI-FDSVYTVQSDVWS 264 Query: 228 LGILLYDMVC-GDIPFEH---DEEIIRG-----QVFFRQRVSSECQHLIRWCLALRPSDR 278 GILL+++ G P+ + + + Q+ +++ C AL P+ R Sbjct: 265 YGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHR 324 Query: 279 PTFEEI 284 PTF++I Sbjct: 325 PTFQQI 330 >3A4O-X nrPDB Length = 286 Score = 207 bits (526), Expect = 7e-54, Method: Composition-based stats. Identities = 67/269 (24%), Positives = 120/269 (44%), Gaps = 26/269 (9%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 E ++ LG+G FG V+ G +++ VA+K ++ +S L E Sbjct: 8 WEIPRESIKLVKRLGAGQFGEVWMGYY-NNSTKVAVKTLKPGTMSVQAFLE-------EA 59 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT--ERGALQEELARSFF 148 L+K + ++RL R + +I E L DF+ E G + F Sbjct: 60 NLMKTLQHDK--LVRLYAVVTREEPIYIITEYMAK-GSLLDFLKSDEGGKVLLPKLIDFS 116 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV-- 206 Q+ E + + +HRD++ N+L+ + K+ DFG +++D YT +G + Sbjct: 117 AQIAEGMAYIERKNYIHRDLRAANVLVSESL-MCKIADFGLARVIEDNEYTAREGAKFPI 175 Query: 207 -YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEE------IIRGQVFFR-Q 257 ++ PE I + + +S VWS GILLY++V G IP+ + +G R + Sbjct: 176 KWTAPEAINFGCFTIKS-DVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVE 234 Query: 258 RVSSECQHLIRWCLALRPSDRPTFEEIQN 286 E +++ C + +RPTF+ +Q+ Sbjct: 235 NCPDELYDIMKMCWKEKAEERPTFDYLQS 263 >6BXI-A nrPDB Length = 333 Score = 206 bits (525), Expect = 9e-54, Method: Composition-based stats. Identities = 70/309 (22%), Positives = 129/309 (41%), Gaps = 61/309 (19%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 ++ ++G G FG V + A+K + K + + ++ + + E +L + Sbjct: 6 EDFESLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGH---IRAERDILVE 62 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 S + V+++ F+ + LI+E P D+ + ++ L EE + + + + A+ Sbjct: 63 ADSLW--VVKMFYSFQDKLNLYLIMEFL-PGGDMMTLLMKKDTLTEEETQFYIAETVLAI 119 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDF-------------- 201 H G +HRDIK +N+L+D G +KL DFG LK T+F Sbjct: 120 DSIHQLGFIHRDIKPDNLLLDSK-GHVKLSDFGLCTGLKKAHRTEFYRNLNHSLPSDFTF 178 Query: 202 -----------------------DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCG 238 GT Y PE Y+ + WSLG+++Y+M+ G Sbjct: 179 QNMNSKRKAETWKRNRRQLAFSTVGTPDYIAPEVFMQTGYN-KLCDWWSLGVIMYEMLIG 237 Query: 239 DIPF------EHDEEIIRGQ--VFFRQ--RVSSECQHLI-RWCLALRPSDR---PTFEEI 284 PF E ++++ + + F +S + + LI R+C R P EEI Sbjct: 238 YPPFCSETPQETYKKVMNWKETLTFPPEVPISEKAKDLILRFCCEW--EHRIGAPGVEEI 295 Query: 285 QNHPWMQDV 293 +++ + + V Sbjct: 296 KSNSFFEGV 304 >5SYS-A nrPDB Length = 286 Score = 206 bits (525), Expect = 9e-54, Method: Composition-based stats. Identities = 67/281 (23%), Positives = 112/281 (39%), Gaps = 29/281 (10%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 E ++ LG G FG + G VAIK ++ +S E Sbjct: 13 WEIPRESLRLEVKLGQGCFGECWMGTWNGT-TRVAIKTLKPGTMSPEA-------FLQEA 64 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER--GALQEELARSFF 148 ++KK+ +++L ++ E L DF+ L+ Sbjct: 65 QVMKKLRH--EKLVQLYAVVSEEP-IYIVTEYMSK-GSLLDFLKGEMGKYLRLPQLVDMA 120 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV-- 206 Q+ + + +HRD++ NIL+ N K+ DFG L++D YT G + Sbjct: 121 AQIASGMAYVERMNYVHRDLRAANILVGENL-VCKVADFGLARLIEDNEYTARQGAKFPI 179 Query: 207 -YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH---DEEIIRGQVFFRQRVSS 261 ++ PE Y R+ +S VWS GILL ++ G +P+ E + + + +R Sbjct: 180 KWTAPEAALYGRFTIKS-DVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPP 238 Query: 262 EC----QHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQE 298 EC L+ C P +RPTFE +Q +++D E Sbjct: 239 ECPESLHDLMCQCWRKDPEERPTFEYLQA--FLEDYFTSTE 277 >5VO2-A nrPDB Length = 300 Score = 206 bits (524), Expect = 1e-53, Method: Composition-based stats. Identities = 61/268 (22%), Positives = 113/268 (42%), Gaps = 32/268 (11%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 +GSG G+V+ G VA+K V + +D + L+K+ + Sbjct: 20 VGSGAQGAVFLGRFH--GEEVAVKKVRDLKETD-------------IKHLRKLKH--PNI 62 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGV 163 I + + +++E L++ + + L + + + + H + Sbjct: 63 ITFKGVCTQAPCYCILMEFCA-QGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKI 121 Query: 164 LHRDIKDENILIDLNRGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPEWIRYHRYHGRS 222 +HRD+K N+LI + +K+ DFG+ L D + F GT + PE IR Sbjct: 122 IHRDLKSPNMLITYDD-VVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPV-SEK 179 Query: 223 AAVWSLGILLYDMVCGDIPFE--HDEEIIRG------QVFFRQRVSSECQHLIRWCLALR 274 +WS G++L++++ G+IP++ II G + + L+R C + Sbjct: 180 VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSK 239 Query: 275 PSDRPTFEEIQNHPWMQD---VLLPQET 299 P +RP+F +I H + + PQET Sbjct: 240 PRNRPSFRQILLHLDIASADVLSTPQET 267 >4E93-A nrPDB Length = 377 Score = 205 bits (523), Expect = 1e-53, Method: Composition-based stats. Identities = 69/296 (23%), Positives = 112/296 (37%), Gaps = 28/296 (9%) Query: 2 LLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDN 61 LLS L + + P + +G +G G FG V+SG +DN Sbjct: 85 LLSTQQPLTKKSGVVLH-----RAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADN 139 Query: 62 LPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILE 121 VA+K + D + E +LK+ S ++RL+ + +++E Sbjct: 140 TLVAVKSCRETLPPDL-----KAKFLQEARILKQYSH--PNIVRLIGVCTQKQPIYIVME 192 Query: 122 RPEPVQDLFDFITERG-ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG 180 + D F+ G L+ + + + + +HRD+ N L+ + Sbjct: 193 LVQG-GDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVT-EKN 250 Query: 181 ELKLIDFGSGALLKDTVYTDFDGTRV----YSPPEWIRYHRYHGRSAAVWSLGILLYDMV 236 LK+ DFG D VY G R ++ PE + Y RY S VWS GILL++ Sbjct: 251 VLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSES-DVWSFGILLWETF 309 Query: 237 C-GDIPFEHDEEIIR-------GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEI 284 G P+ + G++ + L+ C A P RP+F I Sbjct: 310 SLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTI 365 >5H2U-A nrPDB Length = 267 Score = 205 bits (523), Expect = 1e-53, Method: Composition-based stats. Identities = 72/267 (26%), Positives = 113/267 (42%), Gaps = 24/267 (8%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVV 91 E ++ + LGSG FG V+ G+ D + VAIK + +D L + + E+ Sbjct: 2 ERPREEFTLCRKLGSGYFGEVFEGLWK-DRVQVAIKVISRD------NLLHQQMLQSEIQ 54 Query: 92 LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE--RGALQEELARSFFW 149 +KK+ ++ L D +I E L + + + L W Sbjct: 55 AMKKLRHKH--ILALYAVVSVGDPVYIITELMAK-GSLLELLRDSDEKVLPVSELLDIAW 111 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVY-- 207 QV E + + + +HRD+ NIL+ N K+ DFG L+K+ VY D Y Sbjct: 112 QVAEGMCYLESQNYIHRDLAARNILVGENT-LCKVGDFGLARLIKEDVYLSHDHNIPYKW 170 Query: 208 SPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH---DEEIIRGQVFFRQRVSSEC 263 + PE + Y +S VWS GILL++M G +P+ E +R +R EC Sbjct: 171 TAPEALSRGHYSTKS-DVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLEC 229 Query: 264 ----QHLIRWCLALRPSDRPTFEEIQN 286 L+ C P RPTF+ ++ Sbjct: 230 PPSVHKLMLTCWCRDPEQRPTFKALRE 256 >2I6L-A nrPDB Length = 320 Score = 205 bits (523), Expect = 1e-53, Method: Composition-based stats. Identities = 71/324 (21%), Positives = 127/324 (39%), Gaps = 68/324 (20%) Query: 33 PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVL 92 L S+Y LG GG G V+S + + VAIK + ++D + + R E+ + Sbjct: 8 DLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKI---VLTDPQSVKHALR---EIKI 61 Query: 93 LKKVSSGFSGVIRLL--------------DWFERPDSFVLILERPEPVQDLFDFITERGA 138 ++++ ++++ +S ++ E E DL + + E+G Sbjct: 62 IRRLDHD--NIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMET--DLANVL-EQGP 116 Query: 139 LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY 198 L EE AR F +Q+L +++ H+ VLHRD+K N+ I+ LK+ DFG ++ D Y Sbjct: 117 LLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIM-DPHY 175 Query: 199 TDFD------GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQ 252 + T+ Y P + + ++ +W+ G + +M+ G F E+ + Q Sbjct: 176 SHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQ 235 Query: 253 VFFR------------------------------------QRVSSECQHLIRWCLALRPS 276 + +S E + L P Sbjct: 236 LILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREAVDFLEQILTFSPM 295 Query: 277 DRPTFEEIQNHPWMQDVLLPQETA 300 DR T EE +HP+M P + Sbjct: 296 DRLTAEEALSHPYMSIYSFPMDEP 319 >5X5O-A nrPDB Length = 310 Score = 205 bits (523), Expect = 2e-53, Method: Composition-based stats. Identities = 56/262 (21%), Positives = 107/262 (40%), Gaps = 32/262 (12%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 Q G G FGSVY +S + VA+K + K + E +L Sbjct: 15 DDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK--------------IEKEAEILSV 60 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA--LQEELARSFFWQVLE 153 +S +I+ P ++ ++ E + L+D+I + + + ++ V + Sbjct: 61 LSHR--NIIQFYGVILEPPNYGIVTEYAS-LGSLYDYINSNRSEEMDMDHIMTWATDVAK 117 Query: 154 AVRHCHNC---GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPP 210 + + H V+HRD+K N++I + G LK+ DFG+ T + GT + P Sbjct: 118 GMHYLHMEAPVKVIHRDLKSRNVVIAAD-GVLKICDFGASRFHNHTTHMSLVGTFPWMAP 176 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEI--------IRGQVFFRQRVSSE 262 E I+ + +S G++L++M+ ++PF+ E + ++ Sbjct: 177 EVIQSLPV-SETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRS 235 Query: 263 CQHLIRWCLALRPSDRPTFEEI 284 L+ C RP+F++I Sbjct: 236 FAELLHQCWEADAKKRPSFKQI 257 >2XS0-A nrPDB Length = 386 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 72/355 (20%), Positives = 129/355 (36%), Gaps = 71/355 (20%) Query: 13 RAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKD 72 R+ N+ ++ ++ G + +YQ +GSG G V + VAIK + + Sbjct: 5 RSKRDNNFYSVEI--GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP 62 Query: 73 RISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWF------ERPDSFVLILERPEPV 126 + + R E+VL+K V+ +I LL+ F E +++E + Sbjct: 63 ----FQNQTHAKRAYRELVLMKCVNH--KNIIGLLNVFTPQKSLEEFQDVYIVMELMDA- 115 Query: 127 QDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLID 186 +L I L E +Q+L ++H H+ G++HRD+K NI++ + LK++D Sbjct: 116 -NLCQVIQME--LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSD-CTLKILD 171 Query: 187 FGSGALLKDT-VYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD 245 FG + + F TR Y PE I Y + +WS+G ++ +M+ G + F Sbjct: 172 FGLARTAGTSFMMVPFVVTRYYRAPEVILGMGYK-ENVDIWSVGCIMGEMIKGGVLFPGT 230 Query: 246 EEIIRGQVFFRQ---RVSS----------------------------------------- 261 + I + Q Sbjct: 231 DHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNK 290 Query: 262 ----ECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPS 312 + + L+ L + S R + +E HP++ P E P Sbjct: 291 LKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEA--PPPKIPDKQ 343 >4GS6-A nrPDB Length = 315 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 61/269 (22%), Positives = 109/269 (40%), Gaps = 38/269 (14%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 + +V ++G G FG V + VAIK +E + +E+ L + Sbjct: 9 KEIEVEEVVGRGAFGVVCKAKWRA--KDVAIKQIESE--------SERKAFIVELRQLSR 58 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQ---EELARSFFWQVL 152 V+ +++L P L++E E L++ + L A S+ Q Sbjct: 59 VNH--PNIVKLYGACLNP--VCLVMEYAEG-GSLYNVLHGAEPLPYYTAAHAMSWCLQCS 113 Query: 153 EAVRHCHNCG---VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSP 209 + V + H+ ++HRD+K N+L+ LK+ DFG+ ++ T T+ G+ + Sbjct: 114 QGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQ-THMTNNKGSAAWMA 172 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR------------Q 257 PE Y V+S GI+L++++ PF +EI + Sbjct: 173 PEVFEGSNY-SEKCDVFSWGIILWEVITRRKPF---DEIGGPAFRIMWAVHNGTRPPLIK 228 Query: 258 RVSSECQHLIRWCLALRPSDRPTFEEIQN 286 + + L+ C + PS RP+ EEI Sbjct: 229 NLPKPIESLMTRCWSKDPSQRPSMEEIVK 257 >3G0E-A nrPDB Length = 336 Score = 205 bits (522), Expect = 2e-53, Method: Composition-based stats. Identities = 64/303 (21%), Positives = 117/303 (38%), Gaps = 45/303 (14%) Query: 20 LHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSG-----IRVSDNLPVAIKHVEKDRI 74 + T+L + E ++ G LG+G FG V I+ + VA+K ++ Sbjct: 30 IDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPS-- 87 Query: 75 SDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT 134 L + E+ +L + + ++ LL ++I E DL +F+ Sbjct: 88 ---AHLTEREALMSELKVLSYLGN-HMNIVNLLGACTIGGPTLVITEYCC-YGDLLNFLR 142 Query: 135 ERG------------------ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILID 176 + AL E SF +QV + + + +HRD+ NIL+ Sbjct: 143 RKRDSFICSKTSPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLT 202 Query: 177 LNRGELKLIDFGSGALLKDTVYTDFDGTRV----YSPPEWIRYHRYHGRSAAVWSLGILL 232 R K+ DFG +K+ G + PE I ++ + + VWS GI L Sbjct: 203 HGRIT-KICDFGLARDIKNDSNYVVKGNARLPVKWMAPESI-FNCVYTFESDVWSYGIFL 260 Query: 233 YDMVC-GDIPFEH---DEEIIRG-----QVFFRQRVSSECQHLIRWCLALRPSDRPTFEE 283 +++ G P+ D + + ++ + +E +++ C P RPTF++ Sbjct: 261 WELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQ 320 Query: 284 IQN 286 I Sbjct: 321 IVQ 323 >3HMP-A nrPDB Length = 342 Score = 204 bits (520), Expect = 4e-53, Method: Composition-based stats. Identities = 71/282 (25%), Positives = 115/282 (40%), Gaps = 32/282 (11%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 Y + +GSGG V+ + AIK+V + + E+ L K+ Sbjct: 58 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRN----EIAYLNKLQ 112 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 +IRL D+ +++E DL ++ ++ ++ +S++ +LEAV Sbjct: 113 QHSDKIIRLYDYEITDQYIYMVME--CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHT 170 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT----DFDGTRVYSPPEWI 213 H G++H D+K N LI G LKLIDFG ++ + GT Y PPE I Sbjct: 171 IHQHGIVHSDLKPANFLIV--DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAI 228 Query: 214 RYHRYH----------GRSAAVWSLGILLYDMVCGDIPFEHDEEIIRG---------QVF 254 + + VWSLG +LY M G PF+ I ++ Sbjct: 229 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIE 288 Query: 255 FRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLP 296 F + Q +++ CL P R + E+ HP++Q P Sbjct: 289 FPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHP 330 >3FI2-A nrPDB Length = 353 Score = 204 bits (519), Expect = 5e-53, Method: Composition-based stats. Identities = 69/335 (20%), Positives = 125/335 (37%), Gaps = 67/335 (20%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 G + +YQ +GSG G V + + VAIK + + + + R Sbjct: 16 GDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP----FQNQTHAKRAY 71 Query: 88 MEVVLLKKVSSGFSGVIRLLDWF------ERPDSFVLILERPEPVQDLFDFITERGALQE 141 E+VL+K V+ +I LL+ F E L++E + +L I L Sbjct: 72 RELVLMKCVNH--KNIISLLNVFTPQKTLEEFQDVYLVMELMDA--NLCQVIQME--LDH 125 Query: 142 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-VYTD 200 E +Q+L ++H H+ G++HRD+K NI++ + LK++DFG + + T Sbjct: 126 ERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSD-CTLKILDFGLARTAGTSFMMTP 184 Query: 201 FDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQ-------- 252 + TR Y PE I Y + +WS+G ++ +MV I F + I + Sbjct: 185 YVVTRYYRAPEVILGMGYK-ENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGT 243 Query: 253 -------------------------VFFRQRVSSE---------------CQHLIRWCLA 272 + F + + L+ L Sbjct: 244 PCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLV 303 Query: 273 LRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSL 307 + P+ R + ++ HP++ + H++ Sbjct: 304 IDPAKRISVDDALQHPYINVWYXXXXXXDEREHTI 338 >2VD5-A nrPDB Length = 412 Score = 203 bits (518), Expect = 5e-53, Method: Composition-based stats. Identities = 69/306 (22%), Positives = 120/306 (39%), Gaps = 34/306 (11%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 KE +++ ++G G F V A+K + K + GE+ Sbjct: 54 KEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFRE--- 110 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSF 147 E +L V+ + +L F+ + L++E DL +++ G + E+AR + Sbjct: 111 ERDVL--VNGDRRWITQLHFAFQDENYLYLVMEYYVG-GDLLTLLSKFGERIPAEMARFY 167 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDF---DGT 204 +++ A+ H G +HRDIK +NIL+D G ++L DFGS L+ GT Sbjct: 168 LAEIVMAIDSVHRLGYVHRDIKPDNILLD-RCGHIRLADFGSCLKLRADGTVRSLVAVGT 226 Query: 205 RVYSPPEWIR------YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EIIRGQ 252 Y PE ++ +G W+LG+ Y+M G PF D +I+ + Sbjct: 227 PDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYGKIVHYK 286 Query: 253 V-----FFRQRVSSECQHLIRWCLALRPSDRP---TFEEIQNHPWMQDVLLPQETAEIHL 304 + V E + I+ L P R + + HP+ L + + Sbjct: 287 EHLSLPLVDEGVPEEARDFIQRLLCP-PETRLGRGGAGDFRTHPFF--FGLDWDGLRDSV 343 Query: 305 HSLSPG 310 +P Sbjct: 344 PPFTPD 349 >5G6V-A nrPDB Length = 324 Score = 203 bits (518), Expect = 6e-53, Method: Composition-based stats. Identities = 68/292 (23%), Positives = 109/292 (37%), Gaps = 49/292 (16%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 Y LG G + +VY G + VA+K + + E EV LLK + Sbjct: 4 YIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEH-----EEGAPCTAIREVSLLKDLK 58 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGAL-QEELARSFFWQVLEAVR 156 ++ L D S L+ E + DL ++ + G + + F +Q+L + Sbjct: 59 HA--NIVTLHDIIHTEKSLTLVFEYLDK--DLKQYLDDCGNIINMHNVKLFLFQLLRGLA 114 Query: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL--LKDTVYTDFDGTRVYSPPEWIR 214 +CH VLHRD+K +N+LI+ RGELKL DFG + Y + T Y PP+ + Sbjct: 115 YCHRQKVLHRDLKPQNLLIN-ERGELKLADFGLARAKSIPTKTYDNEVVTLWYRPPDILL 173 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR------------------ 256 + +W +G + Y+M G F + FR Sbjct: 174 GSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEE 233 Query: 257 ------------------QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 R+ S+ L+ L +R + E+ HP+ Sbjct: 234 FKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 285 >2PL0-A nrPDB Length = 289 Score = 203 bits (518), Expect = 7e-53, Method: Composition-based stats. Identities = 73/271 (26%), Positives = 117/271 (43%), Gaps = 27/271 (9%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 E E ++ LG+G FG V+ G + + VA+K +++ +S L Sbjct: 16 DEWEVPRETLKLVERLGAGQFGEVWMGYY-NGHTKVAVKSLKQGSMSPDAFLA------- 67 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT--ERGALQEELARS 146 E L+K++ ++RL + +I E E L DF+ L Sbjct: 68 EANLMKQLQHQR--LVRLYAVV-TQEPIYIITEYMEN-GSLVDFLKTPSGIKLTINKLLD 123 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV 206 Q+ E + +HRD++ NIL+ K+ DFG L++D YT +G + Sbjct: 124 MAAQIAEGMAFIEERNYIHRDLRAANILVSDTLS-CKIADFGLARLIEDNEYTAREGAKF 182 Query: 207 ---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH------DEEIIRGQVFFR 256 ++ PE I Y + +S VWS GILL ++V G IP+ + + RG R Sbjct: 183 PIKWTAPEAINYGTFTIKS-DVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVR 241 Query: 257 Q-RVSSECQHLIRWCLALRPSDRPTFEEIQN 286 E L+R C RP DRPTF+ +++ Sbjct: 242 PDNCPEELYQLMRLCWKERPEDRPTFDYLRS 272 >4XCU-A nrPDB Length = 300 Score = 203 bits (517), Expect = 7e-53, Method: Composition-based stats. Identities = 63/293 (21%), Positives = 112/293 (38%), Gaps = 35/293 (11%) Query: 20 LHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGI-------RVSDNLPVAIKHVEKD 72 + + L E + +G LG G FG V R VA+K ++ Sbjct: 1 MVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLK-- 58 Query: 73 RISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDF 132 D + + E+ ++K + +I LL + +I+E +L +F Sbjct: 59 ---DNASDKDLADLVSEMEVMK-LIGRHKNIINLLGVCTQEGPLYVIVE-CAAKGNLREF 113 Query: 133 ITER-------GALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLI 185 + R G L + S +QV +++ + +HRD+ N+L+ + +K+ Sbjct: 114 LRARRPPGSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTED-NVMKIA 172 Query: 186 DFGSGALLK--DTVYTDFDG--TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDI 240 DFG + D +G + PE + + R + + VWS GILL+++ G Sbjct: 173 DFGLARGVHHIDYYKKTSNGRLPVKWMAPEAL-FDRVYTHQSDVWSFGILLWEIFTLGGS 231 Query: 241 PFEHD------EEIIRGQVFF-RQRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 P+ + G E L+R C PS RPTF+++ Sbjct: 232 PYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVE 284 >3SXS-A nrPDB Length = 268 Score = 202 bits (514), Expect = 2e-52, Method: Composition-based stats. Identities = 59/267 (22%), Positives = 112/267 (41%), Gaps = 25/267 (9%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVV 91 E + + LGSG FG V G VA+K +++ +S+ E Sbjct: 4 ELKREEITLLKELGSGQFGVVKLGKWK-GQYDVAVKMIKEGSMSEDE-------FFQEAQ 55 Query: 92 LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQ 150 + K+S +++ + ++ E L +++ G L+ + Sbjct: 56 TMMKLSH--PKLVKFYGVCSKEYPIYIVTEYISN-GCLLNYLRSHGKGLEPSQLLEMCYD 112 Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---Y 207 V E + + +HRD+ N L+D + +K+ DFG + D Y GT+ + Sbjct: 113 VCEGMAFLESHQFIHRDLAARNCLVDRDLC-VKVSDFGMTRYVLDDQYVSSVGTKFPVKW 171 Query: 208 SPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF--EHDEEII----RGQVFFRQRV- 259 S PE Y +Y +S VW+ GIL++++ G +P+ + E++ +G +R + Sbjct: 172 SAPEVFHYFKYSSKS-DVWAFGILMWEVFSLGKMPYDLYTNSEVVLKVSQGHRLYRPHLA 230 Query: 260 SSECQHLIRWCLALRPSDRPTFEEIQN 286 S ++ C P RPTF+++ + Sbjct: 231 SDTIYQIMYSCWHELPEKRPTFQQLLS 257 >3CJF-A nrPDB Length = 309 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 62/290 (21%), Positives = 112/290 (38%), Gaps = 38/290 (13%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGI-----RVSDNLPVAIKHVEKDRISDWGELPN 82 + E + +G LG G FG V + + VA+K +++ Sbjct: 19 ASKWEFPRDRLNLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSE----- 73 Query: 83 GTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG----- 137 + E+ +L + V+ LL +P ++++ +L ++ + Sbjct: 74 HRALMSELKILIHIGH-HLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVP 132 Query: 138 -------ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSG 190 L E + +QV + + + +HRD+ NIL+ + +K+ DFG Sbjct: 133 YKDLYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLS-EKNVVKICDFGLA 191 Query: 191 A-LLKDTVYTDFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH- 244 + KD Y R+ + PE I + R + + VWS G+LL+++ G P+ Sbjct: 192 RDIYKDPDYVRKGDARLPLKWMAPETI-FDRVYTIQSDVWSFGVLLWEIFSLGASPYPGV 250 Query: 245 --DEEIIR-----GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNH 287 DEE R ++ + E + C PS RPTF E+ H Sbjct: 251 KIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPSQRPTFSELVEH 300 >4H1J-A nrPDB Length = 293 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 63/258 (24%), Positives = 113/258 (43%), Gaps = 26/258 (10%) Query: 42 PLLGSGGFGSVYSGI---RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSS 98 +LG G FG VY G+ + + VA+K +KD D N + E V++K + Sbjct: 30 RILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLD-----NKEKFMSEAVIMKNLDH 84 Query: 99 GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFWQVLEAVRH 157 +++L+ E + +I+E P +L ++ +L+ + Q+ +A+ + Sbjct: 85 --PHIVKLIGIIEEEPT-WIIMELY-PYGELGHYLERNKNSLKVLTLVLYSLQICKAMAY 140 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV---YSPPEWIR 214 + +HRDI NIL+ +KL DFG ++D Y TR+ + PE I Sbjct: 141 LESINCVHRDIAVRNILVASPEC-VKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESIN 199 Query: 215 YHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEE------IIRGQVFFRQR-VSSECQHL 266 + R+ ++ VW + +++++ G PF E + +G + L Sbjct: 200 FRRFTT-ASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTL 258 Query: 267 IRWCLALRPSDRPTFEEI 284 + C PSDRP F E+ Sbjct: 259 MTRCWDYDPSDRPRFTEL 276 >2ZMD-A nrPDB Length = 390 Score = 202 bits (513), Expect = 2e-52, Method: Composition-based stats. Identities = 70/282 (24%), Positives = 114/282 (40%), Gaps = 32/282 (11%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 Y + +GSGG V+ + AIK+V + + E+ L K+ Sbjct: 58 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRN----EIAYLNKLQ 112 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 +IRL D+ +++E DL ++ ++ ++ +S++ +LEAV Sbjct: 113 QHSDKIIRLYDYEITDQYIYMVME--CGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHT 170 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT----DFDGTRVYSPPEWI 213 H G++H D+K N LI G LKLIDFG ++ + G Y PPE I Sbjct: 171 IHQHGIVHSDLKPANFLIV--DGMLKLIDFGIANQMQPDTTSVVKDSQVGAVNYMPPEAI 228 Query: 214 RYHRYH----------GRSAAVWSLGILLYDMVCGDIPFEHDEEIIRG---------QVF 254 + + VWSLG +LY M G PF+ I ++ Sbjct: 229 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIE 288 Query: 255 FRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLP 296 F + Q +++ CL P R + E+ HP++Q P Sbjct: 289 FPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHP 330 >5AP3-A nrPDB Length = 313 Score = 201 bits (512), Expect = 3e-52, Method: Composition-based stats. Identities = 71/282 (25%), Positives = 115/282 (40%), Gaps = 32/282 (11%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 Y + +GSGG V+ + AIK+V + + E+ L K+ Sbjct: 30 YSILKQIGSGGSSKVFQVLNEK-KQIYAIKYVNLEEADNQTLDSYRN----EIAYLNKLQ 84 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 +IRL D+ +++E DL ++ ++ ++ +S++ +LEAV Sbjct: 85 QHSDKIIRLYDYEITDQYIYMVME--CGNIDLNGWLKKKKSIDPWERKSYWKNMLEAVHT 142 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT----DFDGTRVYSPPEWI 213 H G++H D+K N LI G LKLIDFG ++ + GT Y PPE I Sbjct: 143 IHQHGIVHSDLKPANFLIV--DGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAI 200 Query: 214 RYHRYH----------GRSAAVWSLGILLYDMVCGDIPFEHDEEIIRG---------QVF 254 + + VWSLG +LY M G PF+ I ++ Sbjct: 201 KDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIE 260 Query: 255 FRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLP 296 F + Q +++ CL P R + E+ HP++Q P Sbjct: 261 FPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHP 302 >2XNP-A nrPDB Length = 279 Score = 201 bits (511), Expect = 4e-52, Method: Composition-based stats. Identities = 74/275 (26%), Positives = 116/275 (42%), Gaps = 29/275 (10%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 Y+V +G+G +G R SD + K ++ +++ + EV LL++ Sbjct: 6 EDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTE----AEKQMLVSEVNLLRE 61 Query: 96 VSSGFSGVIRLLDWFERPDS--FVLILERPEPVQDLFDFI----TERGALQEELARSFFW 149 + ++R D + +++E E DL I ER L EE Sbjct: 62 LKH--PNIVRYYDRIIDRTNTTLYIVMEYCEG-GDLASVITKGTKERQYLDEEFVLRVMT 118 Query: 150 QVLEAVRHCHN-----CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY--TDFD 202 Q+ A++ CH VLHRD+K N+ +D + +KL DFG +L F Sbjct: 119 QLTLALKECHRRSDGGHTVLHRDLKPANVFLDGKQN-VKLGDFGLARILNHDTSFAKTFV 177 Query: 203 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE------IIRGQV-FF 255 GT Y PE + Y+ +S +WSLG LLY++ PF + I G+ Sbjct: 178 GTPYYMSPEQMNRMSYNEKS-DIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRI 236 Query: 256 RQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 R S E +I L L+ RP+ EEI +P + Sbjct: 237 PYRYSDELNEIITRMLNLKDYHRPSVEEILENPLI 271 >4P5Q-A nrPDB Length = 361 Score = 200 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 61/271 (22%), Positives = 113/271 (41%), Gaps = 27/271 (9%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRV---SDNLPVAIKHVEKDRISDWGELPNGTRVP 87 KE + + ++G+G FG V SG + VAIK ++ Sbjct: 28 KELDATNISIDKVVGAGEFGEVCSGRLKLPSKKEISVAIKTLKVGYTEK-----QRRDFL 82 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA-LQEELARS 146 E ++ + +IRL + +++ E E L F+ + A Sbjct: 83 GEASIMGQFDH--PNIIRLEGVVTKSKPVMIVTEYMEN-GSLDSFLRKHDAQFTVIQLVG 139 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT---VYTDFDG 203 + +++ + G +HRD+ NILI+ N K+ DFG +L+D YT G Sbjct: 140 MLRGIASGMKYLSDMGYVHRDLAARNILINSNL-VCKVSDFGLSRVLEDDPEAAYTTRGG 198 Query: 204 --TRVYSPPEWIRYHRYHGRSAAVWSLGILLYD-MVCGDIPFEH--DEEIIRG-----QV 253 ++ PE I Y ++ ++ VWS GI+L++ M G+ P+ ++++I+ ++ Sbjct: 199 KIPIRWTSPEAIAYRKFTS-ASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRL 257 Query: 254 FFRQRVSSECQHLIRWCLALRPSDRPTFEEI 284 + L+ C ++RP FE+I Sbjct: 258 PPPMDCPAALYQLMLDCWQKDRNNRPKFEQI 288 >1FVR-A nrPDB Length = 327 Score = 200 bits (510), Expect = 5e-52, Method: Composition-based stats. Identities = 63/277 (22%), Positives = 107/277 (38%), Gaps = 36/277 (12%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPV--AIKHVEKDRISDWGELPNGTRVPMEVVLL 93 + + ++G G FG V D L + AIK +++ D + E+ +L Sbjct: 25 NDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKD-----DHRDFAGELEVL 79 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG---------------- 137 K+ +I LL E L +E P +L DF+ + Sbjct: 80 CKLGH-HPNIINLLGACEHRGYLYLAIEYA-PHGNLLDFLRKSRVLETDPAFAIANSTAS 137 Query: 138 ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV 197 L + F V + + +HRD+ NIL+ N K+ DFG + V Sbjct: 138 TLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENY-VAKIADFGLSRGQEVYV 196 Query: 198 YTDFDGTRV-YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF------EHDEEII 249 V + E + Y + ++ VWS G+LL+++V G P+ E E++ Sbjct: 197 KKTMGRLPVRWMAIESLNYS-VYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLP 255 Query: 250 RGQVFFRQ-RVSSECQHLIRWCLALRPSDRPTFEEIQ 285 +G + E L+R C +P +RP+F +I Sbjct: 256 QGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQIL 292 >3V5Q-A nrPDB Length = 297 Score = 200 bits (509), Expect = 7e-52, Method: Composition-based stats. Identities = 61/278 (21%), Positives = 100/278 (35%), Gaps = 44/278 (15%) Query: 40 VGPLLGSGGFGSVYSGIR-----VSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 + LG G FG V+ D + VA+K ++ L E LL Sbjct: 19 LKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDP------TLAARKDFQREAELLT 72 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA---------------- 138 + +++ D +++ E + DL F+ G Sbjct: 73 NLQHEH--IVKFYGVCGDGDPLIMVFEYMK-HGDLNKFLRAHGPDAMILVDGQPRQAKGE 129 Query: 139 LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY 198 L Q+ + + + +HRD+ N L+ N +K+ DFG + T Y Sbjct: 130 LGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANL-LVKIGDFGMSRDVYSTDY 188 Query: 199 TDFDG----TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF------EHDEE 247 G + PPE I Y ++ S VWS G++L+++ G P+ E E Sbjct: 189 YRVGGHTMLPIRWMPPESIMYRKFTTES-DVWSFGVILWEIFTYGKQPWFQLSNTEVIEC 247 Query: 248 IIRGQVFFRQR-VSSECQHLIRWCLALRPSDRPTFEEI 284 I +G+V R R E ++ C P R +EI Sbjct: 248 ITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 285 >3N9X-A nrPDB Length = 432 Score = 200 bits (508), Expect = 8e-52, Method: Composition-based stats. Identities = 69/367 (18%), Positives = 124/367 (33%), Gaps = 103/367 (28%) Query: 27 PGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRV 86 G + + Y + L+G G +G VY + VAIK V + + +L + R+ Sbjct: 17 QGIKNVHVPDNYIIKHLIGRGSYGYVYLAYDKNTEKNVAIKKVNRM----FEDLIDCKRI 72 Query: 87 PMEVVLLKKVSSGFSGVIRLLDWF-----ERPDSFVLILERPEPVQDLFDFITERGALQE 141 E+ +L ++ S + +IRL D + D ++LE + DL L E Sbjct: 73 LREITILNRLKSDY--IIRLYDLIIPDDLLKFDELYIVLEIADS--DLKKLFKTPIFLTE 128 Query: 142 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT----- 196 E ++ + +L H G++HRD+K N L++ + +K+ DFG + Sbjct: 129 EHIKTILYNLLLGENFIHESGIIHRDLKPANCLLNQD-CSVKVCDFGLARTINSEKDTNI 187 Query: 197 -------------------VYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMV- 236 T TR Y PE I + +S +WS G + +++ Sbjct: 188 VNDLEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTKSIDIWSTGCIFAELLN 247 Query: 237 ----------CGDIPFEHDE---------------------------------------- 246 F Sbjct: 248 MLQSHINDPTNRFPLFPGSSCFPLSPDRNSKKVHEKSNRDQLNIIFNIIGTPTEDDLKNI 307 Query: 247 ---EIIRGQVFFRQR-----------VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 E+I+ F R +S + +L+ L P+ R T ++ +HP+++D Sbjct: 308 NKPEVIKYIKLFPHRKPINLKQKYPSISDDGINLLESMLKFNPNKRITIDQALDHPYLKD 367 Query: 293 VLLPQET 299 V + Sbjct: 368 VRKKKLE 374 >5Y86-A nrPDB Length = 588 Score = 200 bits (508), Expect = 9e-52, Method: Composition-based stats. Identities = 71/342 (20%), Positives = 123/342 (35%), Gaps = 83/342 (24%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 89 ++ L +Y+V ++G G FG V VA+K V ++ + E Sbjct: 201 PRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRF-------HRQAAEE 253 Query: 90 VVLLKKVS----SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEEL 143 + +L+ + +G VI +L+ F + + E DL++ I + +L Sbjct: 254 IRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLS--IDLYELIKKNKFQGFSVQL 311 Query: 144 ARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLN-RGELKLIDFGSGALLKDTVYTDFD 202 R F +L+++ H ++H D+K ENIL+ + R K+IDFGS +YT + Sbjct: 312 VRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYT-YI 370 Query: 203 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGD---------------------IP 241 +R Y PE I RY +WS G +L +++ G P Sbjct: 371 QSRFYRAPEIILGSRYSTP-IDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPP 429 Query: 242 FEHDEEIIRGQVFF-----------------------------RQRVSSECQH------- 265 + E+ R + F ++R + Sbjct: 430 PKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKG 489 Query: 266 --------LIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQET 299 ++ CL PS R T + HPW+ + T Sbjct: 490 CDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLT 531 >2W96-B nrPDB Length = 306 Score = 200 bits (508), Expect = 1e-51, Method: Composition-based stats. Identities = 67/300 (22%), Positives = 107/300 (35%), Gaps = 50/300 (16%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 S+Y+ +G G +G+VY VA+K V GE EV LL+ Sbjct: 3 TSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPN----GEEGLPISTVREVALLR 58 Query: 95 KVSS-GFSGVIRLLDWF-----ERPDSFVLILERPEPVQDLFDFITERGA--LQEELARS 146 ++ + V+RL+D +R L+ E + QDL ++ + L E + Sbjct: 59 RLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVD--QDLRTYLDKAPPPGLPAETIKD 116 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTD-FDGTR 205 Q L + H ++HRD+K ENIL+ G +KL DFG + + D T Sbjct: 117 LMRQFLRGLDFLHANCIVHRDLKPENILVTSG-GTVKLADFGLARIYSYQMALDPVVVTL 175 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF---------- 255 Y PE + Y +WS+G + +M F + E + F Sbjct: 176 WYRAPEVLLQSTYATP-VDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDD 234 Query: 256 -RQRVS------------------SECQH----LIRWCLALRPSDRPTFEEIQNHPWMQD 292 + VS E + L+ L P R + H ++ Sbjct: 235 WPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHK 294 >3PG1-A nrPDB Length = 362 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 67/322 (20%), Positives = 118/322 (36%), Gaps = 56/322 (17%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHV-----EKDRISDWGELPNGT 84 E ++S Y V + SG +G+V +G+ S+ +PVAIK V + ++ + Sbjct: 16 ELHAMQSPYTVQRFISSGSYGAVCAGVD-SEGIPVAIKRVFNTVSDGRTVNILSDSFLCK 74 Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERPD-----SFVLILERPEPVQDLFDFIT-ERGA 138 RV E+ LL ++ L D F + L+ E DL I +R Sbjct: 75 RVLREIRLLNHFHH--PNILGLRDIFVHFEEPAMHKLYLVTELMRT--DLAQVIHDQRIV 130 Query: 139 LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL-LKDTV 197 + + + F + +L + H GV+HRD+ NIL+ + ++ + DF D Sbjct: 131 ISPQHIQYFMYHILLGLHVLHEAGVVHRDLHPGNILL-ADNNDITICDFNLAREDTADAN 189 Query: 198 YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIR- 250 T + R Y PE + + + +WS G ++ +M F +I+ Sbjct: 190 KTHYVTHRWYRAPELVMQFKGFTKLVDMWSAGCVMAEMFNRKALFRGSTFYNQLNKIVEV 249 Query: 251 ----------------GQVFFRQRVS---------------SECQHLIRWCLALRPSDRP 279 + + R +S LI L P R Sbjct: 250 VGTPKIEDVVMFSSPSARDYLRNSLSNVPARAWTAVVPTADPVALDLIAKMLEFNPQRRI 309 Query: 280 TFEEIQNHPWMQDVLLPQETAE 301 + E+ HP+ + + P + E Sbjct: 310 STEQALRHPYFESLFDPLDLTE 331 >1TKI-A nrPDB Length = 321 Score = 199 bits (507), Expect = 1e-51, Method: Composition-based stats. Identities = 71/281 (25%), Positives = 114/281 (40%), Gaps = 24/281 (8%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVV 91 + L +Y + LG G FG V+ + S K V+ + + V E+ Sbjct: 1 KELYEKYMIAEDLGRGEFGIVHRCVETSSKKTYMAKFVK-------VKGTDQVLVKKEIS 53 Query: 92 LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI-TERGALQEELARSFFWQ 150 +L ++ L + FE + V+I E + D+F+ I T L E S+ Q Sbjct: 54 ILNIARHR--NILHLHESFESMEELVMIFEFISGL-DIFERINTSAFELNEREIVSYVHQ 110 Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNR-GELKLIDFGSGALLK-DTVYTDFDGTRVYS 208 V EA++ H+ + H DI+ ENI+ R +K+I+FG LK + Y Sbjct: 111 VCEALQFLHSHNIGHFDIRPENIIYQTRRSSTIKIIEFGQARQLKPGDNFRLLFTAPEYY 170 Query: 209 PPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF------EHDEEIIRGQVFFR----QR 258 PE H + +WSLG L+Y ++ G PF + E I+ + F + Sbjct: 171 APEV-HQHDVVSTATDMWSLGTLVYVLLSGINPFLAETNQQIIENIMNAEYTFDEEAFKE 229 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQET 299 +S E + L R T E HPW++ + T Sbjct: 230 ISIEAMDFVDRLLVKERKSRMTASEALQHPWLKQKIERVST 270 >4XI2-A nrPDB Length = 446 Score = 199 bits (506), Expect = 1e-51, Method: Composition-based stats. Identities = 65/286 (22%), Positives = 122/286 (42%), Gaps = 26/286 (9%) Query: 13 RAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKD 72 N L G E LG+G FG V G VAIK + + Sbjct: 165 SKQNKNAPSTAGLGYGS-WEIDPKDLTFLKELGTGQFGVVKYGKWR-GQYDVAIKMIREG 222 Query: 73 RISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDF 132 +S+ + E ++ +S +++L + +I E L ++ Sbjct: 223 SMSEDEFIE-------EAKVMMNLSH--EKLVQLYGVCTKQRPIFIITEYMAN-GCLLNY 272 Query: 133 ITE-RGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA 191 + E R Q + V EA+ + + LHRD+ N L++ ++G +K+ DFG Sbjct: 273 LREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVN-DQGVVKVSDFGLSR 331 Query: 192 LLKDTVYTDFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF----- 242 + D YT G++ +SPPE + Y ++ +S +W+ G+L++++ G +P+ Sbjct: 332 YVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKS-DIWAFGVLMWEIYSLGKMPYERFTN 390 Query: 243 -EHDEEIIRGQVFFRQRVSSE-CQHLIRWCLALRPSDRPTFEEIQN 286 E E I +G +R ++SE ++ C + +RP+F+ + + Sbjct: 391 SETAEHIAQGLRLYRPHLASERVYTIMYSCWHEKADERPSFKILLS 436 >6E4F-A nrPDB Length = 290 Score = 199 bits (506), Expect = 1e-51, Method: Composition-based stats. Identities = 63/279 (22%), Positives = 120/279 (43%), Gaps = 25/279 (8%) Query: 20 LHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGE 79 T E LG+G FG V G VAIK +++ +S+ Sbjct: 15 FQGTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWR-GQYDVAIKMIKEGSMSEDEF 73 Query: 80 LPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGA 138 + E ++ +S +++L + +I E L +++ E R Sbjct: 74 IE-------EAKVMMNLSH--EKLVQLYGVCTKQRPIFIITEYMAN-GCLLNYLREMRHR 123 Query: 139 LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY 198 Q + V EA+ + + LHRD+ N L++ ++G +K+ DFG + D Y Sbjct: 124 FQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVN-DQGVVKVSDFGLSRYVLDDEY 182 Query: 199 TDFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF------EHDEEI 248 T G++ +SPPE + Y ++ +S +W+ G+L++++ G +P+ E E I Sbjct: 183 TSSVGSKFPVRWSPPEVLMYSKFSSKS-DIWAFGVLMWEIYSLGKMPYERFTNSETAEHI 241 Query: 249 IRGQVFFRQRV-SSECQHLIRWCLALRPSDRPTFEEIQN 286 +G +R + S + ++ C + +RPTF+ + + Sbjct: 242 AQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLS 280 >4PWN-A nrPDB Length = 274 Score = 198 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 54/264 (20%), Positives = 114/264 (43%), Gaps = 23/264 (8%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 +G G F +VY G+ + VA ++ +++ R E +LK + + Sbjct: 18 IGRGSFKTVYKGLDTETTVEVAWCELQDRKLTK----SERQRFKEEAEMLKGLQH--PNI 71 Query: 104 IRLLDWFE---RPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHN 160 +R D +E + ++++ L ++ ++ ++ RS+ Q+L+ ++ H Sbjct: 72 VRFYDSWESTVKGKKCIVLVTELMTSGTLKTYLKRFKVMKIKVLRSWCRQILKGLQFLHT 131 Query: 161 C--GVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPEWIRYHR 217 ++HRD+K +NI I G +K+ D G L K + GT + PE Y Sbjct: 132 RTPPIIHRDLKCDNIFITGPTGSVKIGDLGLATLEKRASFAKSVIGTPEFMAPE--MYEE 189 Query: 218 YHGRSAAVWSLGILLYDMVCGDIPF---EHDEEIIR------GQVFFRQRVSSECQHLIR 268 + S V++ G+ + +M + P+ ++ +I R F + E + +I Sbjct: 190 KYDESVDVYAFGMCMLEMATSEYPYSECQNAAQIYRRVTSGVKPASFDKVAIPEVKEIIE 249 Query: 269 WCLALRPSDRPTFEEIQNHPWMQD 292 C+ +R + +++ NH + Q+ Sbjct: 250 GCIRQNKDERYSIKDLLNHAFFQE 273 >3ALO-A nrPDB Length = 327 Score = 198 bits (504), Expect = 2e-51, Method: Composition-based stats. Identities = 65/289 (22%), Positives = 118/289 (40%), Gaps = 27/289 (9%) Query: 22 ATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELP 81 K++P + + + +G G +GSV + +A+K + Sbjct: 8 KLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQ--- 64 Query: 82 NGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFD---FITERGA 138 ++ M++ ++ + SS +++ R + +E D F + Sbjct: 65 --KQLLMDLDVVMR-SSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDV 121 Query: 139 LQEELARSFFWQVLEAVRHCHNC-GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV 197 + EE+ ++A+ H ++HRDIK NIL+D G +KL DFG L D++ Sbjct: 122 IPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLD-RSGNIKLCDFGISGQLVDSI 180 Query: 198 YTDFD-GTRVYSPPEWI---RYHRYHGRSAAVWSLGILLYDMVCGDIP-------FEHDE 246 D G R Y PE I + + + VWSLGI LY++ G P F+ Sbjct: 181 AKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLT 240 Query: 247 EIIRG-----QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 ++++G + S + + CL S RP ++E+ HP++ Sbjct: 241 QVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI 289 >3TT0-A nrPDB Length = 382 Score = 198 bits (504), Expect = 3e-51, Method: Composition-based stats. Identities = 57/299 (19%), Positives = 117/299 (39%), Gaps = 44/299 (14%) Query: 24 KLAPGKEKEPLESQYQVGPLLGSGGFGSVYSG------IRVSDNL-PVAIKHVEKDRISD 76 +L E + +G LG G FG V + + VA+K ++ D Sbjct: 57 ELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK 116 Query: 77 WGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER 136 + + + E+ ++K + +I LL + +I+E +L +++ R Sbjct: 117 -----DLSDLISEMEMMKMIG-KHKNIINLLGACTQDGPLYVIVEYASK-GNLREYLQAR 169 Query: 137 GA----------------LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG 180 L + S +QV + + + +HRD+ N+L+ + Sbjct: 170 RPPGLEYSYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTED-N 228 Query: 181 ELKLIDFGSGALLK--DTVYTDFDG--TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMV 236 +K+ DFG + D +G + PE + + R + + VWS G+LL+++ Sbjct: 229 VMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEAL-FDRIYTHQSDVWSFGVLLWEIF 287 Query: 237 C-GDIPFEH-----DEEIIRG--QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNH 287 G P+ ++++ ++ ++E ++R C PS RPTF+++ Sbjct: 288 TLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 346 >5A46-A nrPDB Length = 386 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 62/322 (19%), Positives = 125/322 (38%), Gaps = 44/322 (13%) Query: 1 MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSG----- 55 +LL + + L+ + +L E + +G LG G FG V Sbjct: 5 VLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGL 64 Query: 56 -IRVSDNL-PVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERP 113 + + VA+K ++ D + + + E+ ++K + +I LL + Sbjct: 65 DKDKPNRVTKVAVKMLKSDATEK-----DLSDLISEMEMMKMIG-KHKNIINLLGACTQD 118 Query: 114 DSFVLILERPEPVQDLFDFITERGA----------------LQEELARSFFWQVLEAVRH 157 +I+E +L +++ R L + S +QV + + Sbjct: 119 GPLYVIVEYASK-GNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEY 177 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--DTVYTDFDG--TRVYSPPEWI 213 + +HRD+ N+L+ + +K+ DFG + D +G + PE + Sbjct: 178 LASKKCIHRDLAARNVLVTED-NVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEAL 236 Query: 214 RYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH--DEEIIRG-----QVFFRQRVSSECQH 265 + R + + VWS G+LL+++ G P+ EE+ + ++ ++E Sbjct: 237 -FDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYM 295 Query: 266 LIRWCLALRPSDRPTFEEIQNH 287 ++R C PS RPTF+++ Sbjct: 296 MMRDCWHAVPSQRPTFKQLVED 317 >2HK5-A nrPDB Length = 270 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 69/278 (24%), Positives = 121/278 (43%), Gaps = 27/278 (9%) Query: 22 ATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELP 81 A K E ++ LG+G FG V+ + VA+K ++ +S L Sbjct: 1 AQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPGSMSVEAFLA 59 Query: 82 NGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQE 141 E ++K + +++L + +I E L DF+ ++ Sbjct: 60 -------EANVMKTLQHDK--LVKLHAVV-TKEPIYIITEFMAK-GSLLDFLKSDEGSKQ 108 Query: 142 ELAR--SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT 199 L + F Q+ E + +HRD++ NIL+ + K+ DFG +++D YT Sbjct: 109 PLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASL-VCKIADFGLARVIEDNEYT 167 Query: 200 DFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH--DEEIIRG-- 251 +G + ++ PE I + + +S VWS GILL ++V G IP+ + E+IR Sbjct: 168 AREGAKFPIKWTAPEAINFGSFTIKS-DVWSFGILLMEIVTYGRIPYPGMSNPEVIRALE 226 Query: 252 ---QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 ++ + E +++ C RP +RPTFE IQ+ Sbjct: 227 RGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQS 264 >5MJB-A nrPDB Length = 305 Score = 198 bits (503), Expect = 3e-51, Method: Composition-based stats. Identities = 61/275 (22%), Positives = 110/275 (40%), Gaps = 29/275 (10%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNL---PVAIKHVEKDRISDWGELPNGTRVP 87 KE S ++ ++G+G FG VY G VAIK ++ Sbjct: 21 KEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEK-----QRRDFL 75 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER-GALQEELARS 146 E ++ + +IRL + ++I E E L F+ + G Sbjct: 76 SEASIMGQFDHR--NIIRLEGVVTKSRPVMIITEFMENC-ALDSFLRQNDGQFTVIQLVG 132 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT----VYTDFD 202 + +++ +HRD+ NIL++ N K+ DFG L+D YT Sbjct: 133 MLRGIAAGMKYLSEMNYVHRDLAARNILVNSNL-VCKVSDFGLSRYLQDDTSDPTYTSSL 191 Query: 203 GTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYD-MVCGDIPFEH--DEEIIRG----- 251 G ++ ++ PE I Y ++ ++ VWS GI++++ M G+ P+ ++++I Sbjct: 192 GGKIPVRWTAPEAIAYRKFTS-ASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDY 250 Query: 252 QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 ++ + L+ C + RP F EI N Sbjct: 251 RLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVN 285 >4AT3-A nrPDB Length = 299 Score = 197 bits (502), Expect = 4e-51, Method: Composition-based stats. Identities = 61/284 (21%), Positives = 105/284 (36%), Gaps = 43/284 (15%) Query: 40 VGPLLGSGGFGSVYSGIR-----VSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 + LG G FG V+ D + VA+K ++ + + E LL Sbjct: 17 LKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKD------FHREAELLT 70 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA-------------LQE 141 + +++ D +++ E + DL F+ G L + Sbjct: 71 NLQHEH--IVKFYGVCVEGDPLIMVFEYMK-HGDLNKFLRAHGPDAVLMAEGNPPTELTQ 127 Query: 142 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDF 201 Q+ + + + +HRD+ N L+ N +K+ DFG + T Y Sbjct: 128 SQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENL-LVKIGDFGMSRDVYSTDYYRV 186 Query: 202 DG----TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEE------IIR 250 G + PPE I Y ++ S VWSLG++L+++ G P+ I + Sbjct: 187 GGHTMLPIRWMPPESIMYRKFTTES-DVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQ 245 Query: 251 GQVFFRQR-VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 G+V R R E L+ C P R + I H +Q++ Sbjct: 246 GRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGI--HTLLQNL 287 >1JPA-A nrPDB Length = 312 Score = 197 bits (501), Expect = 6e-51, Method: Composition-based stats. Identities = 61/275 (22%), Positives = 111/275 (40%), Gaps = 29/275 (10%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLP---VAIKHVEKDRISDWGELPNGTRVP 87 KE S ++ ++G+G FG V SG VAIK ++ Sbjct: 28 KEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEK-----QRRDFL 82 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER-GALQEELARS 146 E ++ + VI L + ++I E E L F+ + G Sbjct: 83 SEASIMGQFDH--PNVIHLEGVVTKSTPVMIITEFMEN-GSLDSFLRQNDGQFTVIQLVG 139 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT----VYTDFD 202 + +++ + +HRD+ NIL++ N K+ DFG L+D YT Sbjct: 140 MLRGIAAGMKYLADMNYVHRDLAARNILVNSNL-VCKVSDFGLSRFLEDDTSDPTYTSAL 198 Query: 203 GTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYD-MVCGDIPFEH--DEEIIRG----- 251 G ++ ++ PE I+Y ++ ++ VWS GI++++ M G+ P+ ++++I Sbjct: 199 GGKIPIRWTAPEAIQYRKFTS-ASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDY 257 Query: 252 QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 ++ S L+ C + RP F +I N Sbjct: 258 RLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVN 292 >4EQM-A nrPDB Length = 294 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 71/272 (26%), Positives = 124/272 (45%), Gaps = 23/272 (8%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 + + +Y++ LG GG +VY N+ VAIK + L R EV Sbjct: 6 GKIINERYKIVDKLGGGGMSTVYLAEDTILNIKVAIKAIFIPPREKEETL---KRFEREV 62 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQ 150 ++S ++ ++D E D + L++E E L ++I G L + A +F Q Sbjct: 63 HNSSQLSHQ--NIVSMIDVDEEDDCYYLVMEYIEGP-TLSEYIESHGPLSVDTAINFTNQ 119 Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT---DFDGTRVY 207 +L+ ++H H+ ++HRDIK +NILID N+ LK+ DFG L +T T GT Y Sbjct: 120 ILDGIKHAHDMRIVHRDIKPQNILIDSNK-TLKIFDFGIAKALSETSLTQTNHVLGTVQY 178 Query: 208 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-----------EEIIRGQVFFR 256 PE + ++S+GI+LY+M+ G+ PF + + + R Sbjct: 179 FSPEQAKGEA-TDECTDIYSIGIVLYEMLVGEPPFNGETAVSIAIKHIQDSVPNVTTDVR 237 Query: 257 QRVSSECQHLIRWCLALRPSDRP-TFEEIQNH 287 + + ++I ++R T +E+++ Sbjct: 238 KDIPQSLSNVILRATEKDKANRYKTIQEMKDD 269 >3E3P-A nrPDB Length = 360 Score = 197 bits (500), Expect = 8e-51, Method: Composition-based stats. Identities = 72/328 (21%), Positives = 130/328 (39%), Gaps = 60/328 (18%) Query: 19 DLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWG 78 L+A A + ++ + ++QV + G G FG+V G S + VAIK V +D Sbjct: 7 SLNAAAAADERSRKEM-DRFQVERMAGQGTFGTVQLGKEKSTGMSVAIKKVIQDPRFRNR 65 Query: 79 ELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWF-------ERPDSFVLILERP--EPVQDL 129 EL ++ ++ +L +++L +F R +++E + Sbjct: 66 EL----QIMQDLAVLH-----HPNIVQLQSYFYTLGERDRRDIYLNVVMEYVPDTLHRCC 116 Query: 130 FDFITERGALQEELARSFFWQVLEAVRHCH--NCGVLHRDIKDENILIDLNRGELKLIDF 187 ++ + A L + F +Q++ ++ H + V HRDIK N+L++ G LKL DF Sbjct: 117 RNYYRRQVAPPPILIKVFLFQLIRSIGCLHLPSVNVCHRDIKPHNVLVNEADGTLKLCDF 176 Query: 188 GSGALLK-DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD- 245 GS L + +R Y PE I ++++ + +WS+G + +M+ G+ F D Sbjct: 177 GSAKKLSPSEPNVAYICSRYYRAPELIFGNQHYTTAVDIWSVGCIFAEMMLGEPIFRGDN 236 Query: 246 -----EEIIRGQVFFRQRV--------------------------------SSECQHLIR 268 EI+R + V + E L+ Sbjct: 237 SAGQLHEIVRVLGCPSREVLRKLNPSHTDVDLYNSKGIPWSNVFSDHSLKDAKEAYDLLS 296 Query: 269 WCLALRPSDRPTFEEIQNHPWMQDVLLP 296 L P +R E HP+ ++ P Sbjct: 297 ALLQYLPEERMKPYEALCHPYFDELHDP 324 >3VN9-A nrPDB Length = 340 Score = 196 bits (499), Expect = 9e-51, Method: Composition-based stats. Identities = 65/299 (21%), Positives = 120/299 (40%), Gaps = 27/299 (9%) Query: 11 HLRAAPCNDLHATK--LAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKH 68 + P DL + + E + LG G +G V V +A+K Sbjct: 24 QTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKR 83 Query: 69 VEKDRISDWGELPNGTRVPMEVVL-LKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQ 127 + S R+ M++ + ++ V F+ + R + +E + Sbjct: 84 IRATVNSQEQ-----KRLLMDLDISMRTVDCPFT--VTFYGALFREGDVWICMELMDTSL 136 Query: 128 DLF--DFITERGALQEELARSFFWQVLEAVRHCHNC-GVLHRDIKDENILIDLNRGELKL 184 D F I + + E++ +++A+ H H+ V+HRD+K N+LI+ G++K+ Sbjct: 137 DKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINA-LGQVKM 195 Query: 185 IDFGSGALLKDTVYTDFD-GTRVYSPPEWIR---YHRYHGRSAAVWSLGILLYDMV---- 236 DFG L D+V D G + Y PE I + + + +WSLGI + ++ Sbjct: 196 CDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRF 255 Query: 237 ---CGDIPFEHDEEIIR--GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 PF+ ++++ + S+E CL +RPT+ E+ HP+ Sbjct: 256 PYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 314 >4XLV-A nrPDB Length = 328 Score = 196 bits (499), Expect = 9e-51, Method: Composition-based stats. Identities = 62/313 (19%), Positives = 119/313 (38%), Gaps = 44/313 (14%) Query: 16 PCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSG-----IRVSDNLPVAIKHVE 70 + ++ P E E + + LG G FG VY G I+ VA+K V Sbjct: 20 ASDVFPSSVYVP-DEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVN 78 Query: 71 KDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLF 130 + L E ++K + V+RLL + ++++E DL Sbjct: 79 ES-----ASLRERIEFLNEASVMKGFTCHH--VVRLLGVVSKGQPTLVVMELMA-HGDLK 130 Query: 131 DFITE----------RGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG 180 ++ R + ++ + + + + +HRD+ N ++ + Sbjct: 131 SYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDF- 189 Query: 181 ELKLIDFGSGALLKDTVYTDFDG----TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMV 236 +K+ DFG + +T Y G + PE ++ S+ +WS G++L+++ Sbjct: 190 TVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLK-DGVFTTSSDMWSFGVVLWEIT 248 Query: 237 C-GDIPFEH--DEEIIR-----GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQN-- 286 + P++ +E++++ G + L+R C P+ RPTF EI N Sbjct: 249 SLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLL 308 Query: 287 ----HPWMQDVLL 295 HP +V Sbjct: 309 KDDLHPSFPEVSF 321 >2PSQ-A nrPDB Length = 370 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 57/299 (19%), Positives = 119/299 (39%), Gaps = 44/299 (14%) Query: 24 KLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGI-------RVSDNLPVAIKHVEKDRISD 76 +L + E + +G LG G FG V + + + VA+K ++ D Sbjct: 69 ELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 128 Query: 77 WGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER 136 + + + E+ ++K + +I LL + +I+E +L +++ R Sbjct: 129 -----DLSDLVSEMEMMKMIG-KHKNIINLLGACTQDGPLYVIVEYASK-GNLREYLRAR 181 Query: 137 GA----------------LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG 180 + + S +Q+ + + + +HRD+ N+L+ N Sbjct: 182 RPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTEN-N 240 Query: 181 ELKLIDFGSGALLK--DTVYTDFDG--TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMV 236 +K+ DFG + D +G + PE + + R + + VWS G+L++++ Sbjct: 241 VMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEAL-FDRVYTHQSDVWSFGVLMWEIF 299 Query: 237 C-GDIPFEHD--EEIIRG-----QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNH 287 G P+ EE+ + ++ ++E ++R C PS RPTF+++ Sbjct: 300 TLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 358 >3GQL-A nrPDB Length = 326 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 59/299 (19%), Positives = 117/299 (39%), Gaps = 44/299 (14%) Query: 24 KLAPGKEKEPLESQYQVGPLLGSGGFGSVYSG------IRVSDNL-PVAIKHVEKDRISD 76 +L E + +G LG G FG V + + VA+K ++ D Sbjct: 16 ELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEK 75 Query: 77 WGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER 136 + + + E+ ++K + +I LL + +I+E +L +++ R Sbjct: 76 -----DLSDLISEMEMMKMIG-KHKNIINLLGACTQDGPLYVIVEYASK-GNLREYLQAR 128 Query: 137 GA----------------LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG 180 L + S +QV + + + +HRD+ N+L+ + Sbjct: 129 RPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTED-N 187 Query: 181 ELKLIDFGSGALLK--DTVYTDFDG--TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMV 236 +K+ DFG + D +G + PE + + R + + VWS G+LL+++ Sbjct: 188 VMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEAL-FDRIYTHQSDVWSFGVLLWEIF 246 Query: 237 C-GDIPFEH--DEEIIRG-----QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNH 287 G P+ EE+ + ++ ++E ++R C PS RPTF+++ Sbjct: 247 TLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVED 305 >3DKO-A nrPDB Length = 318 Score = 196 bits (498), Expect = 1e-50, Method: Composition-based stats. Identities = 61/271 (22%), Positives = 115/271 (42%), Gaps = 27/271 (9%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLP---VAIKHVEKDRISDWGELPNGTRVP 87 KE S ++ ++G+G FG V SG VAIK ++ Sbjct: 38 KELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEK-----QRRDFL 92 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER-GALQEELARS 146 E ++ + V+ L R ++++E E L F+ + G Sbjct: 93 CEASIMGQFDH--PNVVHLEGVVTRGKPVMIVIEFMEN-GALDAFLRKHDGQFTVIQLVG 149 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT---VYTDFDG 203 + +R+ + G +HRD+ NIL++ N K+ DFG +++D VYT G Sbjct: 150 MLRGIAAGMRYLADMGYVHRDLAARNILVNSNL-VCKVSDFGLSRVIEDDPEAVYTTTGG 208 Query: 204 --TRVYSPPEWIRYHRYHGRSAAVWSLGILLYD-MVCGDIPFEH--DEEIIRG-----QV 253 ++ PE I+Y ++ ++ VWS GI++++ M G+ P+ ++++I+ ++ Sbjct: 209 KIPVRWTAPEAIQYRKFTS-ASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRL 267 Query: 254 FFRQRVSSECQHLIRWCLALRPSDRPTFEEI 284 + L+ C ++RP FE+I Sbjct: 268 PAPMDCPAGLHQLMLDCWQKERAERPKFEQI 298 >5VD3-A nrPDB Length = 311 Score = 195 bits (497), Expect = 1e-50, Method: Composition-based stats. Identities = 70/288 (24%), Positives = 117/288 (40%), Gaps = 17/288 (5%) Query: 12 LRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEK 71 R L + P + + + +Q LG G +G V+ D A+K Sbjct: 33 FRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKR--- 89 Query: 72 DRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFD 131 +S + + R EV +KV +RL +E L E P L Sbjct: 90 -SMSPFRGPKDRARKLAEVGSHEKVG-QHPCCVRLEQAWEEGGILYLQTELCGP--SLQQ 145 Query: 132 FITERGA-LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSG 190 GA L E + L A+ H H+ G++H D+K NI + RG KL DFG Sbjct: 146 HCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGP-RGRCKLGDFGLL 204 Query: 191 ALLKDTVYTDF-DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCG-DIPFEHD--E 246 L + +G Y PE ++ +G +A V+SLG+ + ++ C ++P + + Sbjct: 205 VELGTAGAGEVQEGDPRYMAPELLQGS--YGTAADVFSLGLTILEVACNMELPHGGEGWQ 262 Query: 247 EIIRGQV--FFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 ++ +G + F +SSE + ++ L P R T E + P ++ Sbjct: 263 QLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQ 310 >4Y93-A nrPDB Length = 446 Score = 195 bits (497), Expect = 1e-50, Method: Composition-based stats. Identities = 63/278 (22%), Positives = 120/278 (43%), Gaps = 26/278 (9%) Query: 21 HATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGEL 80 L G E LG+G FG V G VAIK +++ +S+ + Sbjct: 174 STAGLGYGS-WEIDPKDLTFLKELGTGQFGVVKYGKWR-GQYDVAIKMIKEGSMSEDEFI 231 Query: 81 PNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGAL 139 E ++ +S +++L + +I E L +++ E R Sbjct: 232 E-------EAKVMMNLSH--EKLVQLYGVCTKQRPIFIITEYMAN-GCLLNYLREMRHRF 281 Query: 140 QEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT 199 Q + V EA+ + + LHRD+ N L++ ++G +K+ DFG + D YT Sbjct: 282 QTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVN-DQGVVKVSDFGMTRYVLDDEYT 340 Query: 200 DFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF------EHDEEII 249 G++ ++ PE + Y ++ +S +W+ G+L++++ G +P+ E E I Sbjct: 341 SSTGSKFPVKWASPEVLMYSKFSSKS-DIWAFGVLMWEIYSLGKMPYERFTNSETAEHIA 399 Query: 250 RGQVFFRQRVSSE-CQHLIRWCLALRPSDRPTFEEIQN 286 +G R ++SE ++ C + +RPTF+ + + Sbjct: 400 QGLRLPRPHLASERVYAIMYSCWHEKADERPTFKILLS 437 >3ORP-A nrPDB Length = 311 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 66/274 (24%), Positives = 113/274 (41%), Gaps = 28/274 (10%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVV 91 L +Y++G +LG GG V+ + D+ VA+K + D D R E Sbjct: 8 SHLSDRYELGEILGFGGMSEVHLARDLRDHRDVAVKVLRADLARDPSFY---LRFRREAQ 64 Query: 92 LLKKVSSGFSGVIRLLDWFERPDSF----VLILERPEPVQDLFDFITERGALQEELARSF 147 ++ ++ + D E +++E + V L D + G + + A Sbjct: 65 NAAALNH--PAIVAVYDTGEAETPAGPLPYIVMEYVDGV-TLRDIVHTEGPMTPKRAIEV 121 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-----TVYTDFD 202 +A+ H G++HRD+K NI+I +K++DFG + D T Sbjct: 122 IADACQALNFSHQNGIIHRDVKPANIMISATNA-VKVMDFGIARAIADSGNSVTQTAAVI 180 Query: 203 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR---- 258 GT Y PE R RS V+SLG +LY+++ G+ PF D + R+ Sbjct: 181 GTAQYLSPEQARGDSVDARS-DVYSLGCVLYEVLTGEPPFTGDSPVSVAYQHVREDPIPP 239 Query: 259 ------VSSECQHLIRWCLALRPSDRP-TFEEIQ 285 +S++ ++ LA P +R T E++ Sbjct: 240 SARHEGLSADLDAVVLKALAKNPENRYQTAAEMR 273 >4OLI-A nrPDB Length = 645 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 63/293 (21%), Positives = 118/293 (40%), Gaps = 45/293 (15%) Query: 26 APGKEKEPLESQY-QVGPLLGSGGFGSV----YSGIRVSDNLPVAIKHVEKDRISDWGEL 80 +P + +Y + LG G FG V Y VA+K ++ D Sbjct: 342 SPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQ---- 397 Query: 81 PNGTRVPMEVVLLKKVSSGFSGVIRLLDWFER--PDSFVLILERPEPVQDLFDFITERGA 138 + + E+ +L+ + +I+ E S L++E P+ L D++ + Sbjct: 398 -HRSGWKQEIDILRTLYHEH--IIKYKGCCEDQGEKSLQLVMEYV-PLGSLRDYLPRH-S 452 Query: 139 LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD--- 195 + F Q+ E + + H+ +HR++ N+L+D +R +K+ DFG + + Sbjct: 453 IGLAQLLLFAQQICEGMAYLHSQHYIHRNLAARNVLLDNDR-LVKIGDFGLAKAVPEGHE 511 Query: 196 --TVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGD-----IP--FEHDE 246 V D D + PE ++ ++++ ++ VWS G+ LY+++ P F Sbjct: 512 YYRVREDGDSPVFWYAPECLKEYKFY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELI 570 Query: 247 EIIRGQVFF---------------RQRVSSECQHLIRWCLALRPSDRPTFEEI 284 I +GQ+ + E HL++ C S RPTFE + Sbjct: 571 GIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENL 623 Score = 104 bits (259), Expect = 6e-23, Method: Composition-based stats. Identities = 52/299 (17%), Positives = 94/299 (31%), Gaps = 35/299 (11%) Query: 4 SKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLP 63 +I L+HL +++ +L +P E + L G L Sbjct: 45 KEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPL--------VPGRDRGQELR 96 Query: 64 VAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERP 123 V +K ++ L+ +VS + R +++ E Sbjct: 97 VVLKVLDPSHH------DIALAFYETASLMSQVSHTHLAFV--HGVCVRGPENIMVTEYV 148 Query: 124 EPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILI------DL 177 E ERG + Q+ A+ + N ++H ++ NIL+ + Sbjct: 149 EHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEG 208 Query: 178 NRGELKLID--FGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYH-GRSAAVWSLGILLYD 234 +KL D G GAL ++ + PE + + W G L + Sbjct: 209 TSPFIKLSDPGVGLGALSREERVERI----PWLAPECLPGGANSLSTAMDKWGFGATLLE 264 Query: 235 MVC-GDIPFEHDEEIIRGQVFFRQRV-----SSECQHLIRWCLALRPSDRPTFEEIQNH 287 + G+ P + + + RQ + L CL P+ RP+F I Sbjct: 265 ICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRD 323 >3M42-A nrPDB Length = 299 Score = 195 bits (496), Expect = 2e-50, Method: Composition-based stats. Identities = 76/291 (26%), Positives = 116/291 (39%), Gaps = 56/291 (19%) Query: 30 EKEPLESQYQV-GPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 +K + Y+V +LG G G V A+K ++ + + Sbjct: 11 KKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQ-----------DCPKARR 59 Query: 89 EVVLLKKVSSGFSGVIRLLDWFER---PDSFVLILERPEPVQDLFDFITERG--ALQEEL 143 EV L + S ++R++D +E +LI+ +LF I +RG A E Sbjct: 60 EVELHWRASQC-PHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTERE 118 Query: 144 ARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE--LKLIDFGSGALLKDTVYTDF 201 A + EA+++ H+ + HRD+K EN+L R LKL DFG Sbjct: 119 ASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTGEK---- 174 Query: 202 DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE----------EIIRG 251 + +S +WSLG+++Y ++CG PF + I G Sbjct: 175 -----------------YDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMG 217 Query: 252 QVFFRQR----VSSECQHLIRWCLALRPSDRPTFEEIQNHPWM-QDVLLPQ 297 Q F VS E + LIR L P+ R T E NHPW+ Q +PQ Sbjct: 218 QYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQ 268 >3MIA-A nrPDB Length = 351 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 61/317 (19%), Positives = 110/317 (34%), Gaps = 64/317 (20%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 S+Y+ +G G FG V+ VA+K V + + + E+ +L+ Sbjct: 17 SKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPIT----ALREIKILQL 72 Query: 96 VSSGFSGVIRLLDWFERP--------DSFVLILERPEP--VQDLFDFITERGALQEELAR 145 + V+ L++ S L+ + E L + + + + Sbjct: 73 LKH--ENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVK---FTLSEIK 127 Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL------KDTVYT 199 +L + + H +LHRD+K N+LI + G LKL DFG + YT Sbjct: 128 RVMQMLLNGLYYIHRNKILHRDMKAANVLITRD-GVLKLADFGLARAFSLAKNSQPNRYT 186 Query: 200 DFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------------- 246 + T Y PPE + R +G +W G ++ +M + + Sbjct: 187 NRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCG 246 Query: 247 -------------------EIIRGQ-VFFRQRV-----SSECQHLIRWCLALRPSDRPTF 281 E+++GQ + R+ LI L L P+ R Sbjct: 247 SITPEVWPNVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDS 306 Query: 282 EEIQNHPWMQDVLLPQE 298 ++ NH + +P + Sbjct: 307 DDALNHDFFWSDPMPSD 323 >6DBM-A nrPDB Length = 318 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 64/291 (21%), Positives = 117/291 (40%), Gaps = 44/291 (15%) Query: 27 PGKEKEPLESQYQVGPLLGSGGFGSV----YSGIRVSDNLPVAIKHVEKDRISDWGELPN 82 PG + + LG G FG V Y VA+K ++ D + Sbjct: 22 PGDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADAGPQ-----H 76 Query: 83 GTRVPMEVVLLKKVSSGFSGVIRLLDWFERPD--SFVLILERPEPVQDLFDFITERGALQ 140 + E+ +L+ + +I+ E S L++E P+ L D++ ++ Sbjct: 77 RSGWKQEIDILRTLYHEH--IIKYKGCCEDAGAASLQLVMEYV-PLGSLRDYLPRH-SIG 132 Query: 141 EELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD----- 195 F Q+ E + + H+ +HRD+ N+L+D +R +K+ DFG + + Sbjct: 133 LAQLLLFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDR-LVKIGDFGLAKAVPEGHEYY 191 Query: 196 TVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGD-----IP--FEHDEEI 248 V D D + PE ++ ++++ ++ VWS G+ LY+++ P F I Sbjct: 192 RVREDGDSPVFWYAPECLKEYKFY-YASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGI 250 Query: 249 IRGQVFF---------------RQRVSSECQHLIRWCLALRPSDRPTFEEI 284 +GQ+ + +E HL++ C S RPTFE + Sbjct: 251 AQGQMTVLRLTELLERGERLPRPDKCPAEVYHLMKNCWETEASFRPTFENL 301 >2R2P-A nrPDB Length = 295 Score = 195 bits (495), Expect = 3e-50, Method: Composition-based stats. Identities = 61/273 (22%), Positives = 113/273 (41%), Gaps = 27/273 (9%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNL---PVAIKHVEKDRISDWGELPNGTRVP 87 KE S + ++G+G FG V SG PVAIK ++ Sbjct: 17 KEIEASCITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEK-----QRRDFL 71 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER-GALQEELARS 146 E ++ + +I L + +++ E E L F+ + G Sbjct: 72 GEASIMGQFDH--PNIIHLEGVVTKSKPVMIVTEYMEN-GSLDTFLKKNDGQFTVIQLVG 128 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT---VYTDFDG 203 + +++ + G +HRD+ NILI+ N K+ DFG +L+D YT G Sbjct: 129 MLRGISAGMKYLSDMGYVHRDLAARNILINSNL-VCKVSDFGLSRVLEDDPEAAYTTRGG 187 Query: 204 --TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF--EHDEEIIRG-----QV 253 ++ PE I + ++ ++ VWS GI+++++V G+ P+ ++++I+ ++ Sbjct: 188 KIPIRWTAPEAIAFRKFTS-ASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRL 246 Query: 254 FFRQRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 + L+ C + RP F+EI N Sbjct: 247 PSPMDCPAALYQLMLDCWQKERNSRPKFDEIVN 279 >3FME-A nrPDB Length = 290 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 63/276 (22%), Positives = 114/276 (41%), Gaps = 25/276 (9%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVV 91 E + LG G +G V V +A+K + S R+ M++ Sbjct: 3 EVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQ-----KRLLMDLD 57 Query: 92 L-LKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLF--DFITERGALQEELARSFF 148 + ++ V F+ + R + +E + D F I + + E++ Sbjct: 58 ISMRTVDCPFT--VTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIA 115 Query: 149 WQVLEAVRHCHNC-GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD-GTRV 206 +++A+ H H+ V+HRD+K N+LI+ G++K+ DFG L D V D D G + Sbjct: 116 VSIVKALEHLHSKLSVIHRDVKPSNVLINA-LGQVKMCDFGISGYLVDDVAKDIDAGCKP 174 Query: 207 YSPPEWIR---YHRYHGRSAAVWSLGILLYDMV-------CGDIPFEHDEEIIR--GQVF 254 Y PE I + + + +WSLGI + ++ PF+ ++++ Sbjct: 175 YMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQL 234 Query: 255 FRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 + S+E CL +RPT+ E+ HP+ Sbjct: 235 PADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFF 270 >4AN9-A nrPDB Length = 301 Score = 194 bits (494), Expect = 4e-50, Method: Composition-based stats. Identities = 62/273 (22%), Positives = 119/273 (43%), Gaps = 25/273 (9%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 E + ++ LG+G G V+ L +A K + + ++ E+ Sbjct: 4 GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAI-----RNQIIREL 58 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQ 150 +L + +S + ++ F + +E + L + + G + E++ Sbjct: 59 QVLHECNSPY--IVGFYGAFYSDGEISICMEHMDG-GSLDQVLKKAGRIPEQILGKVSIA 115 Query: 151 VLEAVRHC-HNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSP 209 V++ + + ++HRD+K NIL++ RGE+KL DFG L D + +F GTR Y Sbjct: 116 VIKGLTYLREKHKIMHRDVKPSNILVNS-RGEIKLCDFGVSGQLIDEMANEFVGTRSYMS 174 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIP------FEHDEEIIRGQVFFRQRVSS-- 261 PE ++ Y +S +WS+G+ L +M G P FE + I+ ++ S Sbjct: 175 PERLQGTHYSVQS-DIWSMGLSLVEMAVGRYPRPPMAIFELLDYIVN---EPPPKLPSAV 230 Query: 262 ---ECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 E Q + CL P++R +++ H +++ Sbjct: 231 FSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 263 >2Y6O-A nrPDB Length = 291 Score = 194 bits (493), Expect = 4e-50, Method: Composition-based stats. Identities = 61/273 (22%), Positives = 109/273 (39%), Gaps = 27/273 (9%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLP---VAIKHVEKDRISDWGELPNGTRVP 87 KE S ++ ++G G FG V SG VAIK ++ Sbjct: 9 KEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDK-----QRRDFL 63 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER-GALQEELARS 146 E ++ + +I L + ++I E E L F+ + G Sbjct: 64 SEASIMGQFDH--PNIIHLEGVVTKCKPVMIITEYMEN-GSLDAFLRKNDGRFTVIQLVG 120 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT---VYTDFDG 203 + +++ + +HRD+ NIL++ N K+ DFG +L+D YT G Sbjct: 121 MLRGIGSGMKYLSDMSYVHRDLAARNILVNSNL-VCKVSDFGMSRVLEDDPEAAYTTRGG 179 Query: 204 --TRVYSPPEWIRYHRYHGRSAAVWSLGILLYD-MVCGDIPFEH--DEEIIRG-----QV 253 ++ PE I Y ++ ++ VWS GI++++ M G+ P+ ++++I+ ++ Sbjct: 180 KIPIRWTAPEAIAYRKFTS-ASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRL 238 Query: 254 FFRQRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 L+ C SDRP F +I N Sbjct: 239 PPPMDCPIALHQLMLDCWQKERSDRPKFGQIVN 271 >5L6P-A nrPDB Length = 298 Score = 194 bits (493), Expect = 5e-50, Method: Composition-based stats. Identities = 58/275 (21%), Positives = 108/275 (39%), Gaps = 29/275 (10%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLP---VAIKHVEKDRISDWGELPNGTRVP 87 KE S ++ ++G+G FG V G VAIK ++ Sbjct: 14 KEIDVSCVKIEEVIGAGEFGEVCRGRLKQPGRREVFVAIKTLKVGYTER-----QRRDFL 68 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER-GALQEELARS 146 E ++ + +IRL + +++ E E L F+ G Sbjct: 69 SEASIMGQFDH--PNIIRLEGVVTKSRPVMILTEFMENC-ALDSFLRLNDGQFTVIQLVG 125 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT----VYTDFD 202 + +++ +HRD+ NIL++ N K+ DFG L+D YT Sbjct: 126 MLRGIAAGMKYLSEMNYVHRDLAARNILVNSNL-VCKVSDFGLSRFLEDDPSDPTYTSSL 184 Query: 203 GTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYD-MVCGDIPFEH--DEEIIRG----- 251 G ++ ++ PE I Y ++ ++ VWS GI++++ M G+ P+ ++++I Sbjct: 185 GGKIPIRWTAPEAIAYRKFTS-ASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDY 243 Query: 252 QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 ++ + L+ C + RP F +I N Sbjct: 244 RLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVN 278 >3NIE-A nrPDB Length = 429 Score = 193 bits (492), Expect = 6e-50, Method: Composition-based stats. Identities = 70/361 (19%), Positives = 124/361 (34%), Gaps = 106/361 (29%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 89 + + Y++ L+G G +G VY + N VAIK V + + +L + R+ E Sbjct: 22 KNVKVPDNYEIKHLIGRGSYGYVYLAYDKNANKNVAIKKVNRM----FEDLIDCKRILRE 77 Query: 90 VVLLKKVSSGFSGVIRLLDWF-----ERPDSFVLILERPEPVQDLFDFITERGALQEELA 144 + +L ++ S + +IRL D + D ++LE + DL L E+ Sbjct: 78 ITILNRLKSDY--IIRLHDLIIPEDLLKFDELYIVLEIADS--DLKKLFKTPIFLTEQHV 133 Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-------- 196 ++ + +L + H G++HRD+K N L++ + +K+ DFG + Sbjct: 134 KTILYNLLLGEKFIHESGIIHRDLKPANCLLNQD-CSVKICDFGLARTINSDKDIHIVND 192 Query: 197 -------------------VYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC 237 T TR Y PE I + S +WS G + +++ Sbjct: 193 LEEKEENEEPGPHNKNLKKQLTSHVVTRWYRAPELILLQENYTNSIDIWSTGCIFAELLN 252 Query: 238 -------------------------------------------------GDIPFEH---- 244 G P E Sbjct: 253 MMKSHINNPTNRFPLFPGSSCFPLSPDHNSKKVHEKSNRDQLNIIFNVIGTPPEEDLKCI 312 Query: 245 -DEEIIRGQVFFRQR-----------VSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 +E+I+ F R +S E L+ L R T ++ +HP+++D Sbjct: 313 TKQEVIKYIKLFPTRDGIDLSKKYSSISKEGIDLLESMLRFNAQKRITIDKALSHPYLKD 372 Query: 293 V 293 V Sbjct: 373 V 373 >5HI2-A nrPDB Length = 283 Score = 193 bits (491), Expect = 7e-50, Method: Composition-based stats. Identities = 56/286 (19%), Positives = 107/286 (37%), Gaps = 34/286 (11%) Query: 18 NDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDW 77 + H + E + Q VG +GSG FG+VY G D VA+K + ++ + Sbjct: 2 HHHHHGSRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKMLTPQQLQAF 58 Query: 78 GELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG 137 EV +L+K ++ + + ++ + E Sbjct: 59 KN---------EVGVLRKTRHV--NILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHASET 106 Query: 138 ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSG----ALL 193 + + Q + + H ++HRD+K NI + +K+ DFG Sbjct: 107 KFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFL-HEDNTVKIGDFGLATVKSRWS 165 Query: 194 KDTVYTDFDGTRVYSPPEWIRYHRY--HGRSAAVWSLGILLYDMVCGDIPFEHDEE---- 247 + G+ ++ PE IR + + V++ GI+LY+++ G +P+ + Sbjct: 166 GSHQFEQLSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQI 225 Query: 248 ---IIRGQVFF-----RQRVSSECQHLIRWCLALRPSDRPTFEEIQ 285 + RG + R + L+ CL + +RP+F I Sbjct: 226 IEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRIL 271 >4K33-A nrPDB Length = 325 Score = 193 bits (491), Expect = 7e-50, Method: Composition-based stats. Identities = 59/304 (19%), Positives = 123/304 (40%), Gaps = 44/304 (14%) Query: 19 DLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGI-------RVSDNLPVAIKHVEK 71 ++ +L + E ++ +G LG G FG V R + + VA+K ++ Sbjct: 19 NVSELELPADPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKD 78 Query: 72 DRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFD 131 D + + + E+ ++K + +I LL + +++E +L + Sbjct: 79 DATDK-----DLSDLVSEMEMMKMIG-KHKNIINLLGACTQGGPLYVLVEYAAK-GNLRE 131 Query: 132 FITERGA----------------LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILI 175 F+ R L + S +QV + + + +HRD+ N+L+ Sbjct: 132 FLRARRPPGLDYSFDTSKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLV 191 Query: 176 DLNRGELKLIDFGSGALLKD-TVYTDFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGIL 231 + +K+ DFG + + Y + R+ + PE + + R + + VWS G+L Sbjct: 192 TED-NVMKIADFGLARDVHNLDYYKETTNGRLPVKWMAPEAL-FDRVYTHQSDVWSFGVL 249 Query: 232 LYDMVC-GDIPFEHD--EEIIRG-----QVFFRQRVSSECQHLIRWCLALRPSDRPTFEE 283 L+++ G P+ EE+ + ++ + + ++R C PS RPTF++ Sbjct: 250 LWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQ 309 Query: 284 IQNH 287 + Sbjct: 310 LVED 313 >4PDO-A nrPDB Length = 299 Score = 193 bits (491), Expect = 8e-50, Method: Composition-based stats. Identities = 63/271 (23%), Positives = 112/271 (41%), Gaps = 28/271 (10%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSD----NLPVAIKHVEKDRISDWGELPNGTRVP 87 E S ++G+G FG VY G+ + +PVAIK ++ Sbjct: 30 EIHPSCVTRQKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEK-----QRVDFL 84 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER-GALQEELARS 146 E ++ + S +IRL + ++I E E L F+ E+ G Sbjct: 85 GEAGIMGQFSHH--NIIRLEGVISKYKPMMIITEYMEN-GALDKFLREKDGEFSVLQLVG 141 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT---VYTDFDG 203 + +++ N +HRD+ NIL++ N K+ DFG +L+D YT G Sbjct: 142 MLRGIAAGMKYLANMNYVHRDLAARNILVNSNL-VCKVSDFGLSRVLEDDPEATYTTSGG 200 Query: 204 --TRVYSPPEWIRYHRYHGRSAAVWSLGILLYD-MVCGDIPFEH--DEEIIRG-----QV 253 ++ PE I Y ++ ++ VWS GI++++ M G+ P+ + E+++ ++ Sbjct: 201 KIPIRWTAPEAISYRKFTS-ASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRL 259 Query: 254 FFRQRVSSECQHLIRWCLALRPSDRPTFEEI 284 S L+ C + RP F +I Sbjct: 260 PTPMDCPSAIYQLMMQCWQQERARRPKFADI 290 >6O6Q-A nrPDB Length = 335 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 72/302 (23%), Positives = 120/302 (39%), Gaps = 60/302 (19%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 + Y++ LG G + V+ GI + V IK ++ ++ E+ +LK Sbjct: 40 QENYEILRKLGRGKYSEVFLGIDLEKREKVVIKVLKP---------VKRKKIKREISILK 90 Query: 95 KVSSGFSGVIRLLDWFERPDSFV--LILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 + G +I +LD P S LI E + DF + + R + +++L Sbjct: 91 NLVDG-PNIIAMLDVVREPQSKTPGLIFEHINNI----DFRSLYPTFTDYDIRFYMYELL 145 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRVYSPPE 211 +A+ + H+ G++HRD+K N++ID ++ L+LID+G T Y +R + PE Sbjct: 146 KALDYSHSMGIMHRDVKPHNVMIDHDKKLLRLIDWGLAEYYHPGTEYNVRVASRYFKGPE 205 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE-------EIIR-------------- 250 + +R + S +WS G +L MV PF H + +I+R Sbjct: 206 LLVDYRLYDYSLDMWSFGCMLASMVFMKEPFFHGKSNTDQLVQIVRVLGSKNFKKYLEKY 265 Query: 251 -----------GQVFFRQR-----------VSSECQHLIRWCLALRPSDRPTFEEIQNHP 288 G RQ VS E LI L +R T +E H Sbjct: 266 NISLGEEYEDIGYYNKRQWVRFMNENNKDLVSQEFLDLIDRLLRYDHQERLTAKEAMKHA 325 Query: 289 WM 290 + Sbjct: 326 YF 327 >1LUF-A nrPDB Length = 343 Score = 192 bits (489), Expect = 1e-49, Method: Composition-based stats. Identities = 65/308 (21%), Positives = 111/308 (36%), Gaps = 53/308 (17%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRV-----SDNLPVAIKHVEKDRISDWGELPNGTRV 86 E + + +G G FG V+ VA+K ++++ +D Sbjct: 43 EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQ-----ADF 97 Query: 87 PMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER---------- 136 E L+ + + +++LL L+ E DL +F+ Sbjct: 98 QREAALMAEFDN--PNIVKLLGVCAVGKPMCLLFEYMA-YGDLNEFLRSMSPHTVCSLSH 154 Query: 137 --------------GALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL 182 L QV + + +HRD+ N L+ N + Sbjct: 155 SDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENM-VV 213 Query: 183 KLIDFGSGALLKDTVYTDFDGT----RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC- 237 K+ DFG + Y DG + PPE I Y+RY S VW+ G++L+++ Sbjct: 214 KIADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTES-DVWAYGVVLWEIFSY 272 Query: 238 GDIPFEH--DEEIIR-----GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 G P+ EE+I + + E +L+R C + P+DRP+F I H + Sbjct: 273 GLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSI--HRIL 330 Query: 291 QDVLLPQE 298 Q + E Sbjct: 331 QRMCERAE 338 >5X8I-B nrPDB Length = 346 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 69/337 (20%), Positives = 118/337 (35%), Gaps = 86/337 (25%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGI-RVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 + + L ++Y++ LG G FG V I + VA+K V+ Sbjct: 6 QSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVK-------NVDRYCEAAR 58 Query: 88 MEVVLLKKVSSGFSG----VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQ--E 141 E+ +L+ +++ +++L+WFE ++ E +DFI E G L Sbjct: 59 SEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLG--LSTYDFIKENGFLPFRL 116 Query: 142 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG------------------ELK 183 + R +Q+ ++V H+ + H D+K ENIL + ++K Sbjct: 117 DHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIK 176 Query: 184 LIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE 243 ++DFGS D ++ TR Y PE I + + VWS+G +L + G F Sbjct: 177 VVDFGSAT-YDDEHHSTLVSTRHYRAPEVILALGW-SQPCDVWSIGCILIEYYLGFTVFP 234 Query: 244 HDEEIIRGQVFFR---------------------------------QRVSSECQ------ 264 + + R + VS C+ Sbjct: 235 THDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFM 294 Query: 265 -----------HLIRWCLALRPSDRPTFEEIQNHPWM 290 LI+ L P+ R T E HP+ Sbjct: 295 LSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF 331 >5GRN-A nrPDB Length = 356 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 61/302 (20%), Positives = 107/302 (35%), Gaps = 53/302 (17%) Query: 24 KLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGI-----RVSDNLPVAIKHVEKDRISDWG 78 +L E +G +LGSG FG V G R + VA+K ++ S Sbjct: 34 QLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEK 93 Query: 79 ELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG- 137 + + E+ ++ + ++ LL + +I E DL +++ + Sbjct: 94 QA-----LMSELKIMTHLG-PHLNIVNLLGACTKSGPIYIITEYCF-YGDLVNYLHKNRD 146 Query: 138 -------------------------ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDEN 172 L SF +QV + + +HRD+ N Sbjct: 147 SFLSHKKKSMLDSEVKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARN 206 Query: 173 ILIDLNRGELKLIDFGSGA-LLKDTVYTDFDGT---RVYSPPEWIRYHRYHGRSAAVWSL 228 +L+ +K+ DFG ++ D+ Y T + PE I + + + VWS Sbjct: 207 VLL-AQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESI-FDNLYTTLSDVWSY 264 Query: 229 GILLYDMVC-GDIPFEH-------DEEIIRGQVF-FRQRVSSECQHLIRWCLALRPSDRP 279 GILL+++ G P+ +I G +SE ++ C P RP Sbjct: 265 GILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRP 324 Query: 280 TF 281 +F Sbjct: 325 SF 326 >5EG3-A nrPDB Length = 334 Score = 192 bits (488), Expect = 2e-49, Method: Composition-based stats. Identities = 55/299 (18%), Positives = 120/299 (40%), Gaps = 44/299 (14%) Query: 24 KLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGI-------RVSDNLPVAIKHVEKDRISD 76 +L + E + +G LG G FG V + + + VA+K ++ D Sbjct: 23 ELPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEK 82 Query: 77 WGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER 136 + + + E+ ++K + +I LL + +I+ +L +++ R Sbjct: 83 -----DLSDLVSEMEMMKMIG-KHKNIINLLGACTQDGPLYVIVAYASK-GNLREYLRAR 135 Query: 137 GA----------------LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG 180 + + S +Q+ + + + +HRD+ N+L+ N Sbjct: 136 RPPGMELSPDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTEN-N 194 Query: 181 ELKLIDFGSGALLKD-TVYTDFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMV 236 +K+ DFG + + + + R+ + PE + + R + + VWS G+L++++ Sbjct: 195 VMKIADFGLARDINNIDFFKETTNGRLPVKWMAPEAL-FDRVYTHQSDVWSFGVLMWEIF 253 Query: 237 C-GDIPFEHD--EEIIRG-----QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNH 287 G P+ EE+ + ++ ++E ++R C PS RPTF+++ Sbjct: 254 TLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVED 312 >4XUF-A nrPDB Length = 297 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 59/296 (19%), Positives = 115/296 (38%), Gaps = 50/296 (16%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGI-----RVSDNLPVAIKHVEKDRISDWGELPNGT 84 + E + G +LGSG FG V + + ++ VA+K +++ S E Sbjct: 3 KWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREA---- 58 Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT-ERGALQEEL 143 + E+ ++ ++ S ++ LL LI E DL +++ +R E+ Sbjct: 59 -LMSELKMMTQLGS-HENIVNLLGACTLSGPIYLIFEYCC-YGDLLNYLRSKREKFSEDE 115 Query: 144 ARS----------------------FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE 181 F +QV + + +HRD+ N+L+ + Sbjct: 116 IEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK-V 174 Query: 182 LKLIDFGSGA-LLKDTVYTDFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC 237 +K+ DFG ++ D+ Y R+ + PE + + + + VWS GILL+++ Sbjct: 175 VKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESL-FEGIYTIKSDVWSYGILLWEIFS 233 Query: 238 -GDIPFEHDE------EIIRGQVFFRQRV--SSECQHLIRWCLALRPSDRPTFEEI 284 G P+ ++I+ Q + E +++ C A RP+F + Sbjct: 234 LGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 289 >1K9A-A nrPDB Length = 450 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 60/280 (21%), Positives = 112/280 (40%), Gaps = 33/280 (11%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 + ++ +G G FG V G + VA+K ++ D E ++ + Sbjct: 193 KELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKND--------ATAQAFLAEASVMTQ 242 Query: 96 VSSGFSGVIRLLDWF-ERPDSFVLILERPEPVQDLFDFITERGA--LQEELARSFFWQVL 152 + +++LL E ++ E L D++ RG L + F V Sbjct: 243 LRHS--NLVQLLGVIVEEKGGLYIVTEYMAK-GSLVDYLRSRGRSVLGGDCLLKFSLDVC 299 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEW 212 EA+ + +HRD+ N+L+ + K+ DFG T T ++ PE Sbjct: 300 EAMEYLEGNNFVHRDLAARNVLVSED-NVAKVSDFGLTKEASSTQDTGKL-PVKWTAPEA 357 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH---DEEIIRGQVFFRQR----VSSECQ 264 +R ++ +S VWS GILL+++ G +P+ + + R + ++ Sbjct: 358 LREKKFSTKS-DVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVY 416 Query: 265 HLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHL 304 +++ C L + RPTF +++ L T E+HL Sbjct: 417 DVMKNCWHLDAATRPTFLQLREQ------LEHIRTHELHL 450 >5HIE-A nrPDB Length = 302 Score = 191 bits (486), Expect = 3e-49, Method: Composition-based stats. Identities = 56/278 (20%), Positives = 106/278 (38%), Gaps = 38/278 (13%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 + E + Q VG +GSG FG+VY G D VA+K + ++ + Sbjct: 28 SDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGD---VAVKMLTPQQLQAFKN-------- 76 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSF 147 EV +L+K ++ + + ++ + E + Sbjct: 77 -EVGVLRKTRHV--NILLFMG-YSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDI 132 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSG----ALLKDTVYTDFDG 203 Q + + + H ++HRD+K NI + + +K+ DFG + G Sbjct: 133 ARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDL-TVKIGDFGLATVKSRWSGSHQFEQLSG 191 Query: 204 TRVYSPPEWIRYHRY--HGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF------ 255 + ++ PE IR + + V++ GI+LY+++ G +P+ + R Q+ F Sbjct: 192 SILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINN--RDQIIFMVGRGY 249 Query: 256 --------RQRVSSECQHLIRWCLALRPSDRPTFEEIQ 285 R + L+ CL + +RP F +I Sbjct: 250 LSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQIL 287 >5KMM-A nrPDB Length = 329 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 57/273 (20%), Positives = 97/273 (35%), Gaps = 43/273 (15%) Query: 44 LGSGGFGSVYSGIRV-----SDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSS 98 LG G FG V+ D + VA+K +++ S + E LL + Sbjct: 43 LGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD------FQREAELLTMLQH 96 Query: 99 GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA---------------LQEEL 143 ++R +++ E DL F+ G L Sbjct: 97 QH--IVRFFGVCTEGRPLLMVFEYMR-HGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQ 153 Query: 144 ARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDG 203 + QV + + +HRD+ N L+ +K+ DFG + T Y G Sbjct: 154 LLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGL-VVKIGDFGMSRDIYSTDYYRVGG 212 Query: 204 ----TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEE------IIRGQ 252 + PPE I Y ++ S VWS G++L+++ G P+ I +G+ Sbjct: 213 RTMLPIRWMPPESILYRKFTTES-DVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGR 271 Query: 253 VFFRQR-VSSECQHLIRWCLALRPSDRPTFEEI 284 R R E ++R C P R + +++ Sbjct: 272 ELERPRACPPEVYAIMRGCWQREPQQRHSIKDV 304 >5X02-A nrPDB Length = 347 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 59/296 (19%), Positives = 115/296 (38%), Gaps = 50/296 (16%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGI-----RVSDNLPVAIKHVEKDRISDWGELPNGT 84 + E + G +LGSG FG V + + ++ VA+K +++ S E Sbjct: 42 KWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREA---- 97 Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT-ERGALQEEL 143 + E+ ++ ++ S ++ LL LI E DL +++ +R E+ Sbjct: 98 -LMSELKMMTQLGS-HENIVNLLGACTLSGPIYLIFEYCC-YGDLLNYLRSKREKFSEDE 154 Query: 144 ARS----------------------FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE 181 F +QV + + +HRD+ N+L+ + Sbjct: 155 IEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK-V 213 Query: 182 LKLIDFGSGA-LLKDTVYTDFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC 237 +K+ DFG ++ D+ Y R+ + PE + + + + VWS GILL+++ Sbjct: 214 VKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESL-FEGIYTIKSDVWSYGILLWEIFS 272 Query: 238 -GDIPFEHDE------EIIRGQVFFRQRV--SSECQHLIRWCLALRPSDRPTFEEI 284 G P+ ++I+ Q + E +++ C A RP+F + Sbjct: 273 LGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 328 >1BYG-A nrPDB Length = 278 Score = 191 bits (485), Expect = 4e-49, Method: Composition-based stats. Identities = 59/280 (21%), Positives = 113/280 (40%), Gaps = 33/280 (11%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 + ++ +G G FG V G + VA+K ++ D E ++ + Sbjct: 21 KELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKND--------ATAQAFLAEASVMTQ 70 Query: 96 VSSGFSGVIRLLDWF-ERPDSFVLILERPEPVQDLFDFITERGA--LQEELARSFFWQVL 152 + +++LL E ++ E L D++ RG L + F V Sbjct: 71 LRHS--NLVQLLGVIVEEKGGLYIVTEYMAK-GSLVDYLRSRGRSVLGGDCLLKFSLDVC 127 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEW 212 EA+ + +HRD+ N+L+ + K+ DFG T T ++ PE Sbjct: 128 EAMEYLEGNNFVHRDLAARNVLVSED-NVAKVSDFGLTKEASSTQDTGKL-PVKWTAPEA 185 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH---DEEIIRGQVFFRQR----VSSECQ 264 +R ++ +S VWS GILL+++ G +P+ + + R + ++ Sbjct: 186 LREKKFSTKS-DVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVY 244 Query: 265 HLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHL 304 +++ C L + RP+F +++ L +T E+HL Sbjct: 245 EVMKNCWHLDAAMRPSFLQLREQ------LEHIKTHELHL 278 >6FYV-A nrPDB Length = 337 Score = 189 bits (481), Expect = 1e-48, Method: Composition-based stats. Identities = 65/337 (19%), Positives = 118/337 (35%), Gaps = 86/337 (25%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVS-DNLPVAIKHVEKDRISDWGELPNGTRVP 87 + + L ++Y++ LG G FG V I D + VA+K V+ Sbjct: 7 QSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVK-------NVGRYREAAR 59 Query: 88 MEVVLLKKVSSGFSG----VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQE-- 141 E+ +L+ ++S +++L+WF+ ++ E +DFI E L Sbjct: 60 SEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLG--LSTYDFIKENSFLPFQI 117 Query: 142 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILI------------------DLNRGELK 183 + R +Q+ +++ H+ + H D+K ENIL L ++K Sbjct: 118 DHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIK 177 Query: 184 LIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE 243 ++DFGS D ++ TR Y PE I + + VWS+G +L + G F+ Sbjct: 178 VVDFGSAT-YDDEHHSTLVSTRHYRAPEVILALGW-SQPCDVWSIGCILIEYYLGFTVFQ 235 Query: 244 HDE--------------------------------------------------EIIRGQV 253 + + ++ + Sbjct: 236 THDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFM 295 Query: 254 FFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 + L+R L P+ R T +E HP+ Sbjct: 296 LCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFF 332 >3PP0-A nrPDB Length = 338 Score = 189 bits (480), Expect = 1e-48, Method: Composition-based stats. Identities = 68/293 (23%), Positives = 128/293 (43%), Gaps = 29/293 (9%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNL----PVAIKHVEKDRISDWGELPNGTRVPMEV 90 E++ + +LGSG FG+VY GI + D PVAIK + ++ + E Sbjct: 16 ETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKAN-----KEILDEA 70 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSFFW 149 ++ V S + V RLL V ++ + P L D + E RG L + ++ Sbjct: 71 YVMAGVGSPY--VSRLLGICLTST--VQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCM 126 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRV-- 206 Q+ + + + + ++HRD+ N+L+ + +K+ DFG LL D DG +V Sbjct: 127 QIAKGMSYLEDVRLVHRDLAARNVLV-KSPNHVKITDFGLARLLDIDETEYHADGGKVPI 185 Query: 207 -YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH------DEEIIRGQVFFRQR 258 + E I R+ + VWS G+ +++++ G P++ + + +G+ + Sbjct: 186 KWMALESILRRRF-THQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPP 244 Query: 259 VSS-ECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPG 310 + + + ++ C + RP F E+ + + + PQ I L P Sbjct: 245 ICTIDVYMIMVKCWMIDSECRPRFRELVS-EFSRMARDPQRFVVIQNEDLGPA 296 >5AMN-A nrPDB Length = 299 Score = 188 bits (479), Expect = 2e-48, Method: Composition-based stats. Identities = 66/296 (22%), Positives = 115/296 (38%), Gaps = 37/296 (12%) Query: 19 DLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSG-----IRVSDNLPVAIKHVEKDR 73 + A K+ + E +G LG G FG V + VA+K ++++ Sbjct: 6 SVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA 65 Query: 74 ISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI 133 + E +LK+V+ VI+L + +LI+E + L F+ Sbjct: 66 SPSE-----LRDLLSEFNVLKQVNH--PHVIKLYGACSQDGPLLLIVEYAK-YGSLRGFL 117 Query: 134 TE----------RGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELK 183 E AL SF WQ+ + +++ ++HRD+ NIL+ R ++K Sbjct: 118 RESRKVGPGYPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGR-KMK 176 Query: 184 LIDFGSGA-LLKDTVYTDFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-G 238 + DFG + ++ Y R+ + E + + + + VWS G+LL+++V G Sbjct: 177 ISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESL-FDHIYTTQSDVWSFGVLLWEIVTLG 235 Query: 239 DIPFEHDEE------IIRGQVFFRQ-RVSSECQHLIRWCLALRPSDRPTFEEIQNH 287 P+ + G R S E L+ C P RP F +I Sbjct: 236 GNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKD 291 >5HLW-A nrPDB Length = 299 Score = 188 bits (478), Expect = 3e-48, Method: Composition-based stats. Identities = 57/261 (21%), Positives = 111/261 (42%), Gaps = 27/261 (10%) Query: 42 PLLGSGGFGSVYSGIRVSD---NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSS 98 ++G G FG VY G + + + A+K + RI+D GE+ ++ E +++K S Sbjct: 26 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN--RITDIGEV---SQFLTEGIIMKDFSH 80 Query: 99 GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT-ERGALQEELARSFFWQVLEAVRH 157 V+ LL R + L++ DL +FI E + F QV + +++ Sbjct: 81 --PNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKY 138 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV------YSPPE 211 + +HRD+ N ++D +K+ DFG + D Y + E Sbjct: 139 LASKKFVHRDLAARNCMLDEKF-TVKVADFGLARDMHDKEYYSVHNKTGAKLPVKWMALE 197 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH------DEEIIRGQVFF-RQRVSSEC 263 ++ ++ +S VWS G+LL++++ G P+ +++G+ + Sbjct: 198 SLQTQKFTTKS-DVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPL 256 Query: 264 QHLIRWCLALRPSDRPTFEEI 284 ++ C + RP+F E+ Sbjct: 257 YEVMLKCWHPKAEMRPSFSEL 277 >2VWV-A nrPDB Length = 302 Score = 188 bits (477), Expect = 3e-48, Method: Composition-based stats. Identities = 54/273 (19%), Positives = 105/273 (38%), Gaps = 29/273 (10%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLP---VAIKHVEKDRISDWGELPNGTRVP 87 KE S ++ ++G+G FG V G + VAIK ++ Sbjct: 11 KEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTER-----QRREFL 65 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER-GALQEELARS 146 E ++ + +IRL +++ E E L F+ G Sbjct: 66 SEASIMGQFEH--PNIIRLEGVVTNSMPVMILTEFMEN-GALDSFLRLNDGQFTVIQLVG 122 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK----DTVYTDFD 202 + +R+ +HRD+ NIL++ N K+ DFG L+ D T Sbjct: 123 MLRGIASGMRYLAEMSYVHRDLAARNILVNSNL-VCKVSDFGLSRFLEENSSDPTETSSL 181 Query: 203 GTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYD-MVCGDIPFEH--DEEIIRG----- 251 G ++ ++ PE I + ++ ++ WS GI++++ M G+ P+ ++++I Sbjct: 182 GGKIPIRWTAPEAIAFRKFTS-ASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDY 240 Query: 252 QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEI 284 ++ + L+ C + RP F ++ Sbjct: 241 RLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQV 273 >3BBT-B nrPDB Length = 328 Score = 188 bits (477), Expect = 4e-48, Method: Composition-based stats. Identities = 56/267 (20%), Positives = 122/267 (45%), Gaps = 28/267 (10%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNL----PVAIKHVEKDRISDWGELPNGTRVPMEV 90 E++ + +LGSG FG+VY GI V + PVAIK + + E Sbjct: 14 ETELKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKAN-----VEFMDEA 68 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFW 149 +++ + ++RLL P + ++ + P L +++ E + +L ++ Sbjct: 69 LIMASMDH--PHLVRLLGVCLSPT--IQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCV 124 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRV-- 206 Q+ + + + ++HRD+ N+L+ + +K+ DFG LL+ D + DG ++ Sbjct: 125 QIAKGMMYLEERRLVHRDLAARNVLV-KSPNHVKITDFGLARLLEGDEKEYNADGGKMPI 183 Query: 207 -YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH------DEEIIRGQVFFRQR 258 + E I Y ++ + VWS G+ +++++ G P++ + + +G+ + Sbjct: 184 KWMALECIHYRKF-THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPP 242 Query: 259 VSS-ECQHLIRWCLALRPSDRPTFEEI 284 + + + ++ C + RP F+E+ Sbjct: 243 ICTIDVYMVMVKCWMIDADSRPKFKEL 269 >1AD5-A nrPDB Length = 438 Score = 187 bits (476), Expect = 4e-48, Method: Composition-based stats. Identities = 66/281 (23%), Positives = 114/281 (40%), Gaps = 31/281 (11%) Query: 16 PCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRIS 75 PC K E ++ LG+G FG V+ + VA+K ++ +S Sbjct: 162 PCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNK-HTKVAVKTMKPGSMS 220 Query: 76 DWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE 135 L E ++K + +++L + +I E L DF+ Sbjct: 221 VEAFLA-------EANVMKTLQHDK--LVKLHAVV-TKEPIYIITEFMAK-GSLLDFLKS 269 Query: 136 RGALQEELAR--SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL 193 ++ L + F Q+ E + +HRD++ NIL+ + K+ DFG + Sbjct: 270 DEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASL-VCKIADFGLARVG 328 Query: 194 KDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH--DEEIIR 250 ++ PE I + + +S VWS GILL ++V G IP+ + E+IR Sbjct: 329 AKFPIK-------WTAPEAINFGSFTIKS-DVWSFGILLMEIVTYGRIPYPGMSNPEVIR 380 Query: 251 G-----QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 ++ + E +++ C RP +RPTFE IQ+ Sbjct: 381 ALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTFEYIQS 421 >5B2L-A nrPDB Length = 324 Score = 187 bits (476), Expect = 4e-48, Method: Composition-based stats. Identities = 65/295 (22%), Positives = 121/295 (41%), Gaps = 28/295 (9%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 G+ + + + +GSG G V+ +A+K + + G R+ Sbjct: 9 GQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRS-----GNKEENKRIL 63 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSF 147 M++ ++ K S +++ F + +E + +G + E + Sbjct: 64 MDLDVVLK-SHDCPYIVQCFGTFITNTDVFIAMELMGTSAEKLKK-RMQGPIPERILGKM 121 Query: 148 FWQVLEAVRHC-HNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDF-DGTR 205 +++A+ + GV+HRD+K NIL+D RG++KL DFG L D+ G Sbjct: 122 TVAIVKALYYLKEKHGVIHRDVKPSNILLD-ERGQIKLCDFGISGRLVDSKAKTRSAGCA 180 Query: 206 VYSPPEWIR----YHRYHGRSAAVWSLGILLYDMVCGDIPFEH---DEEIIRGQVFFRQR 258 Y PE I + A VWSLGI L ++ G P+++ D E++ + Sbjct: 181 AYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPP 240 Query: 259 V-------SSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHS 306 + S + Q ++ CL RP + ++ H +++ ET E+ + S Sbjct: 241 LLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRY----ETLEVDVAS 291 >3EB0-A nrPDB Length = 383 Score = 187 bits (475), Expect = 5e-48, Method: Composition-based stats. Identities = 64/335 (19%), Positives = 109/335 (32%), Gaps = 88/335 (26%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVV 91 E +Y +G LG+G FG V + A+K V +D E+ Sbjct: 3 ETSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYK----------NRELD 52 Query: 92 LLKKVSSGFSGVIRLLDWFER--------------------------------------P 113 ++K + +I+L+D+F Sbjct: 53 IMKVLDHV--NIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQN 110 Query: 114 DSFVLILERP--EPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDE 171 +I+E + L FI ++ L + +Q+ AV H+ G+ HRDIK + Sbjct: 111 KYLNVIMEYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQ 170 Query: 172 NILIDLNRGELKLIDFGSG-ALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGI 230 N+L++ LKL DFGS L+ + +R Y PE + + S +WS+G Sbjct: 171 NLLVNSKDNTLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGC 230 Query: 231 LLYDMVCGDIPFEHDEEIIR-----------------------------------GQVFF 255 + +++ G F + I + + Sbjct: 231 VFGELILGKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKIL 290 Query: 256 RQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 + S L+ L P R E HP+ Sbjct: 291 PEGTPSLAIDLLEQILRYEPDLRINPYEAMAHPFF 325 >5ZTN-A nrPDB Length = 429 Score = 187 bits (474), Expect = 7e-48, Method: Composition-based stats. Identities = 57/218 (26%), Positives = 96/218 (44%), Gaps = 18/218 (8%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +Y+V ++G G FG V + VA+K V ++ + E+ +L+ + Sbjct: 98 RYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRF-------HRQAAEEIRILEHL 150 Query: 97 S----SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEELARSFFWQ 150 VI +L+ F + + E +L++ I + L R F Sbjct: 151 RKQDKDNTMNVIHMLENFTFRNHICMTFELLS--MNLYELIKKNKFQGFSLPLVRKFAHS 208 Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLN-RGELKLIDFGSGALLKDTVYTDFDGTRVYSP 209 +L+ + H ++H D+K ENIL+ R +K+IDFGS VYT + +R Y Sbjct: 209 ILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYT-YIQSRFYRA 267 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE 247 PE I RY G +WSLG +L +++ G ++E Sbjct: 268 PEVILGARY-GMPIDMWSLGCILAELLTGYPLLPGEDE 304 Score = 42.2 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 11/41 (26%), Positives = 17/41 (41%) Query: 261 SECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAE 301 ++ CL P+ R T + HPW++ L T E Sbjct: 383 PLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGE 423 >3KUL-B nrPDB Length = 325 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 62/291 (21%), Positives = 109/291 (37%), Gaps = 27/291 (9%) Query: 11 HLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNL---PVAIK 67 A P + +E S+ + ++GSG G V G PVAIK Sbjct: 24 QFYAEPHTYEEPGRAGRSFTREIEASRIHIEKIIGSGDSGEVCYGRLRVPGQRDVPVAIK 83 Query: 68 HVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQ 127 ++ E ++ + +IRL R +++ E E Sbjct: 84 ALKAGYTER-----QRRDFLSEASIMGQFDH--PNIIRLEGVVTRGRLAMIVTEYMEN-G 135 Query: 128 DLFDFIT-ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLID 186 L F+ G V +R+ + G +HRD+ N+L+D N K+ D Sbjct: 136 SLDTFLRTHDGQFTIMQLVGMLRGVGAGMRYLSDLGYVHRDLAARNVLVDSNL-VCKVSD 194 Query: 187 FGSGALLKDT---VYTDFDG--TRVYSPPEWIRYHRYHGRSAAVWSLGILLYD-MVCGDI 240 FG +L+D YT G ++ PE I + + ++ VWS G+++++ + G+ Sbjct: 195 FGLSRVLEDDPDAAYTTTGGKIPIRWTAPEAIAFRTFSS-ASDVWSFGVVMWEVLAYGER 253 Query: 241 PF---EHDEEIIRGQVFFRQRVSSEC----QHLIRWCLALRPSDRPTFEEI 284 P+ + + I + +R C L+ C + RP F +I Sbjct: 254 PYWNMTNRDVISSVEEGYRLPAPMGCPHALHQLMLDCWHKDRAQRPRFSQI 304 >4C59-A nrPDB Length = 340 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 71/288 (24%), Positives = 117/288 (40%), Gaps = 39/288 (13%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 G+ E E + +V +L GGF VY V A+K + + E + Sbjct: 19 GQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSN------EEEKNRAII 72 Query: 88 MEVVLLKKVSSGFSGVIRL-----LDWFERPD---SFVLILERPEP-VQDLFDFITERGA 138 EV +KK+S G +++ + E F+L+ E + + + + RG Sbjct: 73 QEVCFMKKLS-GHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQLVEFLKKMESRGP 131 Query: 139 LQEELARSFFWQVLEAVRHCHNCG--VLHRDIKDENILIDLNRGELKLIDFGSGALLKD- 195 L + F+Q AV+H H ++HRD+K EN+L+ N+G +KL DFGS + Sbjct: 132 LSCDTVLKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLS-NQGTIKLCDFGSATTISHY 190 Query: 196 -------------TVYTDFDGTRVYSPPEWIRYHRYH--GRSAAVWSLGILLYDMVCGDI 240 + T +Y PE I + G +W+LG +LY + Sbjct: 191 PDYSWSAQRRALVEEEITRNTTPMYRTPEIIDLYSNFPIGEKQDIWALGCILYLLCFRQH 250 Query: 241 PFEHDEE--IIRGQVFFRQRVSSE--CQHLIRWCLALRPSDRPTFEEI 284 PFE + I+ G+ + LIR L + P +R + E+ Sbjct: 251 PFEDGAKLRIVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEV 298 >4LRM-A nrPDB Length = 334 Score = 186 bits (472), Expect = 1e-47, Method: Composition-based stats. Identities = 63/297 (21%), Positives = 126/297 (42%), Gaps = 36/297 (12%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLP----VAIKHVEKDRISDWGELPNGTRVPMEV 90 E++++ +LGSG FG+VY G+ + + VAIK + + + E Sbjct: 18 ETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKAN-----KEILDEA 72 Query: 91 VLLKKVSS-GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFF 148 ++ V + G V RLL V ++ + P L D++ E + + ++ Sbjct: 73 YVMASVDNPGNPHVCRLLGICLTST--VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWC 130 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYTDFDG--T 204 Q+ + + + + ++HRD+ N+L+ + +K+ DFG LL ++ Y G Sbjct: 131 VQIAKGMNYLEDRRLVHRDLAARNVLVKTPQ-HVKITDFGLAKLLGAEEKEYHAEGGKVP 189 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH------DEEIIRGQVFFRQ 257 + E I HR + + VWS G+ +++++ G P++ + +G+ + Sbjct: 190 IKWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQP 248 Query: 258 RVSS-ECQHLIRWCLALRPSDRPTFEEIQ-------NHPWMQDVLLPQETAEIHLHS 306 + + + ++ C + RP F E+ P Q L+ Q +HL S Sbjct: 249 PICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDP--QRYLVIQGDERMHLPS 303 >3LZB-A nrPDB Length = 327 Score = 185 bits (471), Expect = 2e-47, Method: Composition-based stats. Identities = 56/267 (20%), Positives = 117/267 (43%), Gaps = 28/267 (10%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLP----VAIKHVEKDRISDWGELPNGTRVPMEV 90 E++++ +LGSG FG+VY G+ + + VAIK + + + E Sbjct: 14 ETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKAN-----KEILDEA 68 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFW 149 ++ V + V RLL V ++ + P L D++ E + + ++ Sbjct: 69 YVMASVDN--PHVCRLLGICLTST--VQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCV 124 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYTDFDG--TR 205 Q+ + + + + ++HRD+ N+L+ + +K+ DFG LL ++ Y G Sbjct: 125 QIAKGMNYLEDRRLVHRDLAARNVLVKTPQ-HVKITDFGLAKLLGAEEKEYHAEGGKVPI 183 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH------DEEIIRGQVFFRQR 258 + E I HR + + VWS G+ +++++ G P++ + +G+ + Sbjct: 184 KWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPP 242 Query: 259 VSS-ECQHLIRWCLALRPSDRPTFEEI 284 + + + ++R C + RP F E+ Sbjct: 243 ICTIDVYMIMRKCWMIDADSRPKFREL 269 >3PLS-A nrPDB Length = 298 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 56/259 (21%), Positives = 102/259 (39%), Gaps = 27/259 (10%) Query: 42 PLLGSGGFGSVYSGIRVS---DNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSS 98 ++G G FG VY G + + + AIK + S E+ E +L++ ++ Sbjct: 27 RVIGKGHFGVVYHGEYIDQAQNRIQCAIKSL-----SRITEMQQVEAFLREGLLMRGLNH 81 Query: 99 GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQE-ELARSFFWQVLEAVRH 157 V+ L+ P+ +L DL FI + SF QV + + Sbjct: 82 --PNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNPTVKDLISFGLQVARGMEY 139 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV------YSPPE 211 +HRD+ N ++D + +K+ DFG + D Y R ++ E Sbjct: 140 LAEQKFVHRDLAARNCMLDESF-TVKVADFGLARDILDREYYSVQQHRHARLPVKWTALE 198 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEEIIRGQVF-------FRQRVSSEC 263 ++ +R+ +S VWS G+LL++++ G P+ H + + Sbjct: 199 SLQTYRFTTKS-DVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSL 257 Query: 264 QHLIRWCLALRPSDRPTFE 282 +++ C P+ RPTF Sbjct: 258 YQVMQQCWEADPAVRPTFR 276 >3C1X-A nrPDB Length = 373 Score = 185 bits (469), Expect = 3e-47, Method: Composition-based stats. Identities = 56/261 (21%), Positives = 110/261 (42%), Gaps = 27/261 (10%) Query: 42 PLLGSGGFGSVYSGIRVSD---NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSS 98 ++G G FG VY G + + + A+K + RI+D GE+ ++ E +++K S Sbjct: 95 EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLN--RITDIGEV---SQFLTEGIIMKDFSH 149 Query: 99 GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT-ERGALQEELARSFFWQVLEAVRH 157 V+ LL R + L++ DL +FI E + F QV + ++ Sbjct: 150 --PNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKF 207 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV------YSPPE 211 + +HRD+ N ++D +K+ DFG + D + + E Sbjct: 208 LASKKFVHRDLAARNCMLDEKF-TVKVADFGLARDMYDKEFDSVHNKTGAKLPVKWMALE 266 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH------DEEIIRGQVFF-RQRVSSEC 263 ++ ++ +S VWS G+LL++++ G P+ +++G+ + Sbjct: 267 SLQTQKFTTKS-DVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPL 325 Query: 264 QHLIRWCLALRPSDRPTFEEI 284 ++ C + RP+F E+ Sbjct: 326 YEVMLKCWHPKAEMRPSFSEL 346 >4M7I-A nrPDB Length = 299 Score = 184 bits (468), Expect = 4e-47, Method: Composition-based stats. Identities = 66/303 (21%), Positives = 121/303 (39%), Gaps = 52/303 (17%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 + ++ LG GGFG V+ D+ AIK + +V EV L K Sbjct: 5 TDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRE-----LAREKVMREVKALAK 59 Query: 96 VSSGFSGVIRLLDWFERPD------------SFVLILERPEPVQDLFDFITERGALQEEL 143 + G++R + + + + ++ ++L D++ R ++E Sbjct: 60 LEH--PGIVRYFNAWLEKNTTEKLQPSSPKVYLYIQMQLCRK-ENLKDWMNGRCTIEERE 116 Query: 144 AR---SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV--- 197 F Q+ EAV H+ G++HRD+K NI ++ +K+ DFG + Sbjct: 117 RSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDD-VVKVGDFGLVTAMDQDEEEQ 175 Query: 198 -----------YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE 246 +T GT++Y PE I + Y ++SLG++L++++ PF Sbjct: 176 TVLTPMPAYARHTGQVGTKLYMSPEQIHGNSY-SHKVDIFSLGLILFELLY---PFSTQM 231 Query: 247 EIIRG---------QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQ 297 E +R F Q+ E +++ L+ P +RP I + +D+ P Sbjct: 232 ERVRTLTDVRNLKFPPLFTQKYPCE-YVMVQDMLSPSPMERPEAINIIENAVFEDLDFPG 290 Query: 298 ETA 300 +T Sbjct: 291 KTV 293 >3I81-A nrPDB Length = 315 Score = 184 bits (467), Expect = 4e-47, Method: Composition-based stats. Identities = 59/292 (20%), Positives = 111/292 (38%), Gaps = 37/292 (12%) Query: 20 LHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRV-----SDNLPVAIKHVEKDRI 74 + A + E E + + LG G FG VY G+ VAIK V Sbjct: 2 VSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVN---- 57 Query: 75 SDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT 134 + + E ++K+ + V+RLL + ++I+E DL ++ Sbjct: 58 -EAASMRERIEFLNEASVMKEFNCHH--VVRLLGVVSQGQPTLVIMELMT-RGDLKSYLR 113 Query: 135 ERGALQE----------ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKL 184 E ++ + + + + +HRD+ N ++ + +K+ Sbjct: 114 SLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDF-TVKI 172 Query: 185 IDFGSGALLKDTVYTDFDG----TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GD 239 DFG + +T Y G + PE ++ + S VWS G++L+++ + Sbjct: 173 GDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYS-DVWSFGVVLWEIATLAE 231 Query: 240 IPFEH--DEEIIR-----GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEI 284 P++ +E+++R G + L+R C P RP+F EI Sbjct: 232 QPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEI 283 >3RP9-A nrPDB Length = 458 Score = 184 bits (467), Expect = 5e-47, Method: Composition-based stats. Identities = 53/267 (19%), Positives = 105/267 (39%), Gaps = 48/267 (17%) Query: 4 SKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLP 63 H + P + P + + + +Y++ L+G+G +G V + Sbjct: 26 EGQQRKQHHSSKPTASMPR----PHSDWQ-IPDRYEIRHLIGTGSYGHVCEAYDKLEKRV 80 Query: 64 VAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWF-----ERPDSFVL 118 VAIK + + + +L + R+ E+ +L +++ V+++LD E+ D + Sbjct: 81 VAIKKI----LRVFEDLIDCKRILREIAILNRLNHDH--VVKVLDIVIPKDVEKFDELYV 134 Query: 119 ILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLN 178 +LE + D L E ++ + +L V++ H+ G+LHRD+K N L++ + Sbjct: 135 VLEIADS--DFKKLFRTPVYLTELHIKTLLYNLLVGVKYVHSAGILHRDLKPANCLVNQD 192 Query: 179 RGELKLIDFGSGALLK-----------------------------DTVYTDFDGTRVYSP 209 +K+ DFG + T TR Y Sbjct: 193 -CSVKVCDFGLARTVDYPENGNSQLPISPREDDMNLVTFPHTKNLKRQLTGHVVTRWYRA 251 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMV 236 PE I + + VWS+G + +++ Sbjct: 252 PELILLQENYTEAIDVWSIGCIFAELL 278 Score = 50.3 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 11/34 (32%), Positives = 19/34 (55%) Query: 260 SSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 S++ HL++ L P+ R T E HP+ ++V Sbjct: 370 SADAIHLLKRMLVFNPNKRITINECLAHPFFKEV 403 >6FEX-A nrPDB Length = 321 Score = 184 bits (467), Expect = 5e-47, Method: Composition-based stats. Identities = 60/310 (19%), Positives = 107/310 (34%), Gaps = 61/310 (19%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSG----------------IRVSDNLPVAIKHVEKDRIS 75 + S+ + LG G FG V+ +R L VA+K + D Sbjct: 12 DFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATK 71 Query: 76 DWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE 135 + EV ++ ++ +IRLL + D +I + E DL F++ Sbjct: 72 NA-----RNDFLKEVKIMSRLK--DPNIIRLLGVCVQDDPLCMITDYMEN-GDLNQFLSA 123 Query: 136 RG-------------ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL 182 + + Q+ +R+ +HRD+ N L+ N + Sbjct: 124 HQLEDKAAEGAPGDPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENF-TI 182 Query: 183 KLIDFGSGALLKDTVYTDFDG----TRVYSPPEWIRYHRYHGRSAAVWSLGILLYD--MV 236 K+ DFG L Y G + E I ++ ++ VW+ G+ L++ M+ Sbjct: 183 KIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTT-ASDVWAFGVTLWEVLML 241 Query: 237 CGDIPFE--HDEEIIRGQVFF------------RQRVSSECQHLIRWCLALRPSDRPTFE 282 C PF DE++I F L+ C + RP F Sbjct: 242 CRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFS 301 Query: 283 EIQNHPWMQD 292 ++ H ++ + Sbjct: 302 QL--HRFLAE 309 >5FM2-A nrPDB Length = 355 Score = 184 bits (467), Expect = 5e-47, Method: Composition-based stats. Identities = 66/310 (21%), Positives = 115/310 (37%), Gaps = 51/310 (16%) Query: 19 DLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSG-----IRVSDNLPVAIKHVEKDR 73 + A K+ + E +G LG G FG V + VA+K ++++ Sbjct: 47 SVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA 106 Query: 74 ISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI 133 + E +LK+V+ VI+L + +LI+E + L F+ Sbjct: 107 SPSE-----LRDLLSEFNVLKQVNH--PHVIKLYGACSQDGPLLLIVEYAK-YGSLRGFL 158 Query: 134 TE------------------------RGALQEELARSFFWQVLEAVRHCHNCGVLHRDIK 169 E AL SF WQ+ + +++ ++HRD+ Sbjct: 159 RESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLA 218 Query: 170 DENILIDLNRGELKLIDFGSGA-LLKDTVYTDFDGTRV---YSPPEWIRYHRYHGRSAAV 225 NIL+ R ++K+ DFG + ++ Y R+ + E + + + + V Sbjct: 219 ARNILVAEGR-KMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESL-FDHIYTTQSDV 276 Query: 226 WSLGILLYDMVC-GDIPFEHDEE------IIRGQVFFRQ-RVSSECQHLIRWCLALRPSD 277 WS G+LL+++V G P+ + G R S E L+ C P Sbjct: 277 WSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDK 336 Query: 278 RPTFEEIQNH 287 RP F +I Sbjct: 337 RPVFADISKD 346 >3QA8-A nrPDB Length = 676 Score = 183 bits (466), Expect = 7e-47, Method: Composition-based stats. Identities = 58/233 (24%), Positives = 103/233 (44%), Gaps = 21/233 (9%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 +++ LG+GGFG V I VAIK ++ N R +E+ ++KK++ Sbjct: 16 WEMKERLGTGGFGYVLRWIHQDTGEQVAIKQCRQELSPK-----NRERWCLEIQIMKKLN 70 Query: 98 SGFSGVIRLLDWFERPDSF------VLILERPEPVQDLFDFITER---GALQEELARSFF 148 V+ + + +L +E E DL ++ + L+E R+ Sbjct: 71 H--PNVVSAREVPDGLQKLAPNDLPLLAMEYCEG-GDLRKYLNQFENCCGLKEGPIRTLL 127 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL--KLIDFGSGALL-KDTVYTDFDGTR 205 + A+R+ H ++HRD+K ENI++ L K+ID G L + + T+F GT Sbjct: 128 SDISSALRYLHENRIIHRDLKPENIVLQPGPQRLIHKIIDLGYAKELDQGELCTEFVGTL 187 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR 258 Y PE + +Y WS G L ++ + G PF + + ++ R++ Sbjct: 188 QYLAPELLEQKKYTVT-VDYWSFGTLAFECITGFRPFLPNWQPVQWHGKVREK 239 >3OMV-A nrPDB Length = 307 Score = 183 bits (465), Expect = 8e-47, Method: Composition-based stats. Identities = 56/276 (20%), Positives = 104/276 (37%), Gaps = 33/276 (11%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 E S+ + +GSG FG+VY G D VA+K ++ EV Sbjct: 31 WEIEASEVMLSTRIGSGSFGTVYKGKWHGD---VAVKILK----VVDPTPEQFQAFRNEV 83 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQ 150 +L+K ++ + + D+ ++ + E + Q Q Sbjct: 84 AVLRKTRHV--NILLFMG-YMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQ 140 Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSG----ALLKDTVYTDFDGTRV 206 + + + H ++HRD+K NI + +K+ DFG G+ + Sbjct: 141 TAQGMDYLHAKNIIHRDMKSNNIFLHEGL-TVKIGDFGLATVKSRWSGSQQVEQPTGSVL 199 Query: 207 YSPPEWIRYHRYH--GRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR-------- 256 + PE IR + + V+S GI+LY+++ G++P+ H R Q+ F Sbjct: 200 WMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINN--RDQIIFMVGRGYASP 257 Query: 257 ------QRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 + + L+ C+ +RP F +I + Sbjct: 258 DLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILS 293 >5GNK-A nrPDB Length = 297 Score = 183 bits (465), Expect = 9e-47, Method: Composition-based stats. Identities = 55/267 (20%), Positives = 116/267 (43%), Gaps = 28/267 (10%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLP----VAIKHVEKDRISDWGELPNGTRVPMEV 90 E++++ +LGSG FG+VY G+ + + VAIK + + + E Sbjct: 18 ETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKAN-----KEILDEA 72 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSFFW 149 ++ V + V RLL V ++ + P L D++ E + + ++ Sbjct: 73 YVMASVDN--PHVCRLLGICLTST--VQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCV 128 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYTDFDG--TR 205 Q+ + + + + ++HRD+ N+L+ + +K+ DFG LL ++ Y G Sbjct: 129 QIAKGMNYLEDRRLVHRDLAARNVLVKTPQ-HVKITDFGLAKLLGAEEKEYHAEGGKVPI 187 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH------DEEIIRGQVFFRQR 258 + E I HR + + VWS G+ +++++ G P++ + +G+ + Sbjct: 188 KWMALESIL-HRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPP 246 Query: 259 VSS-ECQHLIRWCLALRPSDRPTFEEI 284 + + + ++ C + RP F E+ Sbjct: 247 ICTIDVYMIMVKCWMIDADSRPKFREL 273 >6BSD-A nrPDB Length = 876 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 64/337 (18%), Positives = 111/337 (32%), Gaps = 73/337 (21%) Query: 17 CNDLHATKLAPGK------EKEPLESQYQVGPLLGSGGFGSVYSG--------------- 55 N L PG + S+ + LG G FG V+ Sbjct: 546 GNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPL 605 Query: 56 -IRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPD 114 +R L VA+K + D + EV ++ ++ +IRLL + D Sbjct: 606 NVRKGHPLLVAVKILRPDATKNA-----RNDFLKEVKIMSRLK--DPNIIRLLGVCVQDD 658 Query: 115 SFVLILERPEPVQDLFDFITERG-------------------ALQEELARSFFWQVLEAV 155 +I + E DL F++ + + Q+ + Sbjct: 659 PLCMITDYMEN-GDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGM 717 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDG----TRVYSPPE 211 R+ +HRD+ N L+ N +K+ DFG L Y G + E Sbjct: 718 RYLATLNFVHRDLATRNCLVGENF-TIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWE 776 Query: 212 WIRYHRYHGRSAAVWSLGILLYD--MVCGDIPFE--HDEEIIRGQVFF------------ 255 I ++ ++ VW+ G+ L++ M+C PF DE++I F Sbjct: 777 CILMGKFTT-ASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSR 835 Query: 256 RQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 L+ C + RP F ++ H ++ + Sbjct: 836 PPACPQGLYELMLRCWSRESEQRPPFSQL--HRFLAE 870 >1ZXE-A nrPDB Length = 303 Score = 182 bits (462), Expect = 2e-46, Method: Composition-based stats. Identities = 62/294 (21%), Positives = 114/294 (38%), Gaps = 51/294 (17%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 S ++ +LG G FG V D+ AIK + + + EV+LL Sbjct: 6 SDFEEIAVLGQGAFGQVVKARNALDSRYYAIKKIR-------HTEEKLSTILSEVMLLAS 58 Query: 96 VSSGF-----------SGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT-ERGALQEEL 143 ++ + ++ + ++ + + +E E L+D I E Q + Sbjct: 59 LNHQYVVRYYAAWLERRNFVKPMTAVKKKSTLFIQMEYCENR-TLYDLIHSENLNQQRDE 117 Query: 144 ARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK--------- 194 F Q+LEA+ + H+ G++HR++K NI ID +R +K+ DFG + Sbjct: 118 YWRLFRQILEALSYIHSQGIIHRNLKPMNIFIDESRN-VKIGDFGLAKNVHRSLDILKLD 176 Query: 195 -------DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE 247 T GT +Y E + ++ ++SLGI+ ++M+ PF E Sbjct: 177 SQNLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIY---PFSTGME 233 Query: 248 ---IIRGQVFFRQRVSSEC--------QHLIRWCLALRPSDRPTFEEIQNHPWM 290 I++ + + +IR + P+ RP + N W+ Sbjct: 234 RVNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWL 287 >1U59-A nrPDB Length = 287 Score = 182 bits (461), Expect = 2e-46, Method: Composition-based stats. Identities = 56/253 (22%), Positives = 108/253 (42%), Gaps = 25/253 (9%) Query: 44 LGSGGFGSVYSGIRV--SDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS 101 LG G FGSV G+ + VAIK +++ E + + E ++ ++ + + Sbjct: 18 LGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT-----EKADTEEMMREAQIMHQLDNPY- 71 Query: 102 GVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNC 161 ++RL+ + ++ +L++E + +R + QV +++ Sbjct: 72 -IVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEK 129 Query: 162 GVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYTDFDGTRV---YSPPEWIRYH 216 +HRD+ N+L+ +NR K+ DFG L D+ YT + + PE I + Sbjct: 130 NFVHRDLAARNVLL-VNRHYAKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFR 188 Query: 217 RYHGRSAAVWSLGILLYDMVC-GDIPFEHDEE------IIRGQVF-FRQRVSSECQHLIR 268 ++ RS VWS G+ +++ + G P++ + I +G+ E L+ Sbjct: 189 KFSSRS-DVWSYGVTMWEALSYGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMS 247 Query: 269 WCLALRPSDRPTF 281 C + DRP F Sbjct: 248 DCWIYKWEDRPDF 260 >4MD7-E nrPDB Length = 391 Score = 182 bits (461), Expect = 2e-46, Method: Composition-based stats. Identities = 67/324 (20%), Positives = 117/324 (36%), Gaps = 61/324 (18%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 + YQ+ LG G + V+ I +++N + + ++ E+ +L+ Sbjct: 36 QDDYQLVRKLGRGKYSEVFEAINITNNEK---------VVVKILKPVKKKKIKREIKILE 86 Query: 95 KVSSGFSGVIRLLDWFERPDSFV--LILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 + G +I L D + P S L+ E DF L + R + +++L Sbjct: 87 NLRGG-PNIITLADIVKDPVSRTPALVFEHVNNT----DFKQLYQTLTDYDIRFYMYEIL 141 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRVYSPPE 211 +A+ +CH+ G++HRD+K N++ID +L+LID+G Y +R + PE Sbjct: 142 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 201 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE--------------------IIRG 251 + ++ + S +WSLG +L M+ PF H + I + Sbjct: 202 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 261 Query: 252 QVFFRQR------------------------VSSECQHLIRWCLALRPSDRPTFEEIQNH 287 + R VS E + L R T E H Sbjct: 262 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 321 Query: 288 PWMQDVLLPQETAEIHLHSLSPGP 311 P+ V+ Q P Sbjct: 322 PYFYTVVKDQARMGSSSMPGGSEP 345 >5KKR-C nrPDB Length = 395 Score = 182 bits (461), Expect = 2e-46, Method: Composition-based stats. Identities = 69/344 (20%), Positives = 127/344 (36%), Gaps = 68/344 (19%) Query: 2 LLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDN 61 L K+ L L L A K E + ++ LG+G G V+ Sbjct: 35 LQKKLEEL-ELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSG 93 Query: 62 LPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILE 121 L +A K + + ++ E+ +L + +S + ++ F + +E Sbjct: 94 LVMARKLIHLEIKPAI-----RNQIIRELQVLHECNSPY--IVGFYGAFYSDGEISICME 146 Query: 122 RPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHC-HNCGVLHRDIKDENILIDLNRG 180 + L + + G + E++ V++ + + ++HRD+K NIL++ RG Sbjct: 147 HMDG-GSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNS-RG 204 Query: 181 ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI 240 E+KL DFG L D++ F GTR Y PE ++ Y +S +WS+G+ L +M G Sbjct: 205 EIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQS-DIWSMGLSLVEMAVGRY 263 Query: 241 P------------------------------------------------FEHDEEIIRGQ 252 P FE + I+ Sbjct: 264 PIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVN-- 321 Query: 253 VFFRQRVSS-----ECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 ++ S E Q + CL P++R +++ H +++ Sbjct: 322 -EPPPKLPSAVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 364 >3ZBF-A nrPDB Length = 322 Score = 182 bits (461), Expect = 3e-46, Method: Composition-based stats. Identities = 61/293 (20%), Positives = 106/293 (36%), Gaps = 42/293 (14%) Query: 22 ATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVS------DNLPVAIKHVEKDRIS 75 + + P +E L + LLGSG FG VY G V + VA+K ++K Sbjct: 23 SIENLPAFPREKLTLRL----LLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTD 78 Query: 76 DWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE 135 E L+ K + +++ L + +ILE E DL ++ + Sbjct: 79 QE-----KIEFLKEAHLMSKFNH--PNILKQLGVCLLNEPQYIILELMEG-GDLLTYLRK 130 Query: 136 RGALQ-------EELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE----LKL 184 + + + +HRD+ N L+ + +K+ Sbjct: 131 ARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKI 190 Query: 185 IDFGSGALLKDTVYTDFDG----TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GD 239 DFG + Y G + PE + + +S VWS GIL+++++ G Sbjct: 191 GDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQS-DVWSFGILIWEILTLGH 249 Query: 240 IPFEHDEEIIR-------GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQ 285 P+ + G++ + + +L+ C A P RPTF IQ Sbjct: 250 QPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQ 302 >2OZO-A nrPDB Length = 613 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 58/280 (20%), Positives = 115/280 (41%), Gaps = 34/280 (12%) Query: 26 APGKEKEPLESQYQVGPL---------LGSGGFGSVYSGIRV--SDNLPVAIKHVEKDRI 74 +P + E L+ + LG G FGSV G+ + VAIK +++ Sbjct: 317 SPFSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVAIKVLKQGT- 375 Query: 75 SDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT 134 E + + E ++ ++ + + ++RL+ + ++ +L++E + Sbjct: 376 ----EKADTEEMMREAQIMHQLDNPY--IVRLIGVCQ-AEALMLVMEMAGGGPLHKFLVG 428 Query: 135 ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL- 193 +R + QV +++ +HR++ N+L+ +NR K+ DFG L Sbjct: 429 KREEIPVSNVAELLHQVSMGMKYLEEKNFVHRNLAARNVLL-VNRHYAKISDFGLSKALG 487 Query: 194 -KDTVYTDFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEE- 247 D+ YT + + PE I + ++ RS VWS G+ +++ + G P++ + Sbjct: 488 ADDSYYTARSAGKWPLKWYAPECINFRKFSSRS-DVWSYGVTMWEALSYGQKPYKKMKGP 546 Query: 248 -----IIRGQVF-FRQRVSSECQHLIRWCLALRPSDRPTF 281 I +G+ E L+ C + DRP F Sbjct: 547 EVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDF 586 >4E20-A nrPDB Length = 290 Score = 181 bits (460), Expect = 3e-46, Method: Composition-based stats. Identities = 61/283 (21%), Positives = 111/283 (39%), Gaps = 45/283 (15%) Query: 36 SQY-QVGPLLGSGGFGSV----YSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 +Y + LG G FG V Y VA+K +++ + E+ Sbjct: 7 KRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQL-----RSGWQREI 61 Query: 91 VLLKKVSSGFSGVIRLLDWFER--PDSFVLILERPEPVQDLFDFITERGALQEELARSFF 148 +L+ + +++ E S L++E P+ L D++ + F Sbjct: 62 EILRTLYHEH--IVKYKGCCEDQGEKSVQLVMEYV-PLGSLRDYLPRHC-VGLAQLLLFA 117 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-----TVYTDFDG 203 Q+ E + + H +HR + N+L+D +R +K+ DFG + + V D D Sbjct: 118 QQICEGMAYLHAQHYIHRALAARNVLLDNDR-LVKIGDFGLAKAVPEGHEYYRVREDGDS 176 Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC----GDIPFEHDEEII---------- 249 + PE ++ +++ ++ VWS G+ LY+++ P E+I Sbjct: 177 PVFWYAPECLKECKFY-YASDVWSFGVTLYELLTYCDSNQSPHTKFTELIGHTQGQMTVL 235 Query: 250 -------RGQVFFRQ-RVSSECQHLIRWCLALRPSDRPTFEEI 284 RG+ R R E HL++ C S RPTF+ + Sbjct: 236 RLTELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNL 278 >4F0G-A nrPDB Length = 287 Score = 181 bits (459), Expect = 4e-46, Method: Composition-based stats. Identities = 53/271 (19%), Positives = 106/271 (39%), Gaps = 25/271 (9%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKH-VEKDRISDWGELPNGTRVPMEVVLL 93 +++ + +G GGFG V+ G V D VAIK + D + + EV ++ Sbjct: 18 DNEIEYEKQIGKGGFGLVHKGRLVKDKSVVAIKSLILGDSEGETEMIEKFQEFQREVFIM 77 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER-GALQEELARSFFWQVL 152 ++ +++L P +++E P DL+ + ++ ++ + + Sbjct: 78 SNLNH--PNIVKLYGLMHNPPR--MVMEFV-PCGDLYHRLLDKAHPIKWSVKLRLMLDIA 132 Query: 153 EAVRHCHNCG--VLHRDIKDENILIDLNRGE----LKLIDFGSGALLKDTVYTDFDGTRV 206 + + N ++HRD++ NI + K+ DFG +V + G Sbjct: 133 LGIEYMQNQNPPIVHRDLRSPNIFLQSLDENAPVCAKVADFGLSQQSVHSV-SGLLGNFQ 191 Query: 207 YSPPEWI-RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE-------EIIRGQVF---F 255 + PE I + A +S ++LY ++ G+ PF+ +IR + Sbjct: 192 WMAPETIGAEEESYTEKADTYSFAMILYTILTGEGPFDEYSYGKIKFINMIREEGLRPTI 251 Query: 256 RQRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 + +++I C + P RP F I Sbjct: 252 PEDCPPRLRNVIELCWSGDPKKRPHFSYIVK 282 >6HMD-A nrPDB Length = 365 Score = 180 bits (458), Expect = 5e-46, Method: Composition-based stats. Identities = 70/323 (21%), Positives = 126/323 (39%), Gaps = 61/323 (18%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 + YQ+ LG G + V+ I +++N + + ++ EV +L+ Sbjct: 52 QDDYQLVRKLGRGKYSEVFEAINITNNE---------RVVVKILKPVKKKKIKREVKILE 102 Query: 95 KVSSGFSGVIRLLDWFERPDSFV--LILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 + G +I+L+D + P S L+ E DF L + R + +++L Sbjct: 103 NLRGGT-NIIKLIDTVKDPVSKTPALVFEYINNT----DFKQLYQILTDFDIRFYMYELL 157 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD-TVYTDFDGTRVYSPPE 211 +A+ +CH+ G++HRD+K N++ID + +L+LID+G Y +R + PE Sbjct: 158 KALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPE 217 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE----------EIIRGQVFF------ 255 + ++ + S +WSLG +L M+ PF H + +++ + + Sbjct: 218 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 277 Query: 256 ----------------------------RQRVSSECQHLIRWCLALRPSDRPTFEEIQNH 287 R VS E L+ L R T +E H Sbjct: 278 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 337 Query: 288 PWMQDVLLPQETAEIHLHSLSPG 310 P+ V+ Q LS G Sbjct: 338 PYFYPVVKEQSQPSADNAVLSSG 360 >6DC0-A nrPDB Length = 292 Score = 180 bits (458), Expect = 5e-46, Method: Composition-based stats. Identities = 60/205 (29%), Positives = 96/205 (46%), Gaps = 12/205 (5%) Query: 100 FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 159 S + +++ + E + D+ ++ R L+EE A F Q++ AV HCH Sbjct: 57 HSNITGIVEVILGETKAYVFFE--KDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCH 114 Query: 160 NCGVLHRDIKDENILI-DLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPEWIRY- 215 ++ D+K + R +L+L ++K D +D G Y PE + Sbjct: 115 QSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTT 174 Query: 216 HRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EIIRGQVFFRQRVSSECQHLIRW 269 Y G++A VWSLG++LY ++ G PF + +I RGQ + +S + + LIR Sbjct: 175 GTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRS 234 Query: 270 CLALRPSDRPTFEEIQNHPWMQDVL 294 L PS+R T EI HPW + VL Sbjct: 235 LLRREPSERLTAPEILLHPWFESVL 259 >5CEK-A nrPDB Length = 263 Score = 180 bits (457), Expect = 7e-46, Method: Composition-based stats. Identities = 60/205 (29%), Positives = 96/205 (46%), Gaps = 12/205 (5%) Query: 100 FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 159 S + +++ + E + D+ ++ R L+EE A F Q++ AV HCH Sbjct: 60 HSNITGIVEVILGETKAYVFFE--KDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCH 117 Query: 160 NCGVLHRDIKDENILI-DLNRGELKLIDFGSGALLK--DTVYTDFDGTRVYSPPEWIRY- 215 ++ D+K + R +L+L ++K D +D G Y PE + Sbjct: 118 QSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTT 177 Query: 216 HRYHGRSAAVWSLGILLYDMVCGDIPFEHDE------EIIRGQVFFRQRVSSECQHLIRW 269 Y G++A VWSLG++LY ++ G PF + +I RGQ + +S + + LIR Sbjct: 178 GTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRS 237 Query: 270 CLALRPSDRPTFEEIQNHPWMQDVL 294 L PS+R T EI HPW + VL Sbjct: 238 LLRREPSERLTAPEILLHPWFESVL 262 >4KIK-B nrPDB Length = 677 Score = 180 bits (457), Expect = 8e-46, Method: Composition-based stats. Identities = 55/233 (23%), Positives = 103/233 (44%), Gaps = 21/233 (9%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 +++ LG+GGFG+V +AIK ++ N R +E+ ++++++ Sbjct: 21 WEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPR-----NRERWCLEIQIMRRLT 75 Query: 98 SGFSGVIRLLDWFERPDSF------VLILERPEPVQDLFDFITER---GALQEELARSFF 148 V+ D E + +L +E + DL ++ + L+E + Sbjct: 76 H--PNVVAARDVPEGMQNLAPNDLPLLAMEYCQG-GDLRKYLNQFENCCGLREGAILTLL 132 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL--KLIDFGSGALL-KDTVYTDFDGTR 205 + A+R+ H ++HRD+K ENI++ L K+ID G L + ++ T F GT Sbjct: 133 SDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTL 192 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR 258 Y PE + +Y WS G L ++ + G PF + + ++ RQ+ Sbjct: 193 QYLAPELLEQQKYTVT-VDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQK 244 >4HZS-A nrPDB Length = 341 Score = 180 bits (456), Expect = 1e-45, Method: Composition-based stats. Identities = 59/265 (22%), Positives = 103/265 (38%), Gaps = 27/265 (10%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIR-VSDNLPV--AIKHVEKDRISDWGELPNGTRVPMEVV 91 E ++ LG G FG V G V A+K ++ D +S + + EV Sbjct: 11 EKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDD---FIREVN 67 Query: 92 LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER-GALQEELARSFFWQ 150 + + +IRL P ++ E P+ L D + + G + Q Sbjct: 68 AMHSLDHR--NLIRLYGVVLTPP-MKMVTELA-PLGSLLDRLRKHQGHFLLGTLSRYAVQ 123 Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYT---DFDGTR 205 V E + + + +HRD+ N+L+ R +K+ DFG L D Y Sbjct: 124 VAEGMGYLESKRFIHRDLAARNLLL-ATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPF 182 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHD--EEIIR-----GQVFFRQ 257 + PE ++ + ++ W G+ L++M G P+ +I+ G+ R Sbjct: 183 AWCAPESLKTRTF-SHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRP 241 Query: 258 -RVSSECQHLIRWCLALRPSDRPTF 281 + +++ C A +P DRPTF Sbjct: 242 EDCPQDIYNVMVQCWAHKPEDRPTF 266 >3EQC-A nrPDB Length = 360 Score = 179 bits (455), Expect = 1e-45, Method: Composition-based stats. Identities = 67/339 (19%), Positives = 123/339 (36%), Gaps = 62/339 (18%) Query: 4 SKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLP 63 K+ L L L A K E + ++ LG+G G V+ L Sbjct: 2 KKLEEL-ELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLV 60 Query: 64 VAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERP 123 +A K + + ++ E+ +L + +S + ++ F + +E Sbjct: 61 MARKLIHLEIKPAI-----RNQIIRELQVLHECNSPY--IVGFYGAFYSDGEISICMEHM 113 Query: 124 EPVQDLFDFITERGALQEELARSFFWQVLEAVRHC-HNCGVLHRDIKDENILIDLNRGEL 182 + L + + G + E++ V++ + + ++HRD+K NIL++ RGE+ Sbjct: 114 DG-GSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNS-RGEI 171 Query: 183 KLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIP- 241 KL DFG L D++ F GTR Y PE ++ Y +S +WS+G+ L +M G P Sbjct: 172 KLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQS-DIWSMGLSLVEMAVGRYPI 230 Query: 242 ------------------------------------FEHDEEIIRGQV--------FFRQ 257 F D Sbjct: 231 PPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLNKFGMDSRPPMAIFELLDYIVNEPPP 290 Query: 258 RVSS-----ECQHLIRWCLALRPSDRPTFEEIQNHPWMQ 291 ++ S E Q + CL P++R +++ H +++ Sbjct: 291 KLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIK 329 >5WNO-A nrPDB Length = 330 Score = 179 bits (454), Expect = 2e-45, Method: Composition-based stats. Identities = 57/309 (18%), Positives = 119/309 (38%), Gaps = 36/309 (11%) Query: 11 HLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIR-----VSDNLPVA 65 + A+ ++ L P E + ++ LG+G FG+V++GI + +PVA Sbjct: 2 AMGASVRPNMSRICLIPSSELQT-----KLDKKLGAGAFGTVFAGIYYPKRAKNVKIPVA 56 Query: 66 IKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEP 125 IK + D+ L T + +++++ + D ++ P Sbjct: 57 IKVFQTDQSQTDEMLEEATNM---------FRLRHDNLLKIIGFCMHDDGLKIVTIY-RP 106 Query: 126 VQDLFDFIT-ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKL 184 + +L +F+ + L + +Q+ +++ V+HRD+ N+L+ +++ Sbjct: 107 LGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLV-KKFNHVEI 165 Query: 185 IDFGSGALLKDT----VYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GD 239 DFG +LK + E H Y ++ VW+ G+ ++++ G Sbjct: 166 TDFGLSKILKHDADSITIKSGKVAIKWLAIEIFSKHCY-THASDVWAFGVTCWEIITFGQ 224 Query: 240 IPFE-------HDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 P++ H+ ++ S + + C P RP F EI + + Sbjct: 225 SPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGF-EILYERFKEF 283 Query: 293 VLLPQETAE 301 +PQ E Sbjct: 284 CKVPQLFLE 292 >6DBN-A nrPDB Length = 316 Score = 178 bits (452), Expect = 3e-45, Method: Composition-based stats. Identities = 52/299 (17%), Positives = 116/299 (38%), Gaps = 51/299 (17%) Query: 27 PGKEKEP--LESQY-QVGPLLGSGGFGSVYSGIRV----SDNLPVAIKHVEKDRISDWGE 79 P E +P E ++ + LG G FG V + VA+K ++ + + Sbjct: 23 PATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGN--- 79 Query: 80 LPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFER--PDSFVLILERPEPVQDLFDFI-TER 136 + + E+ +L+ + +++ + LI+E P L +++ + Sbjct: 80 --HIADLKKEIEILRNLYH--ENIVKYKGICTEDGGNGIKLIMEFL-PSGSLKEYLPKNK 134 Query: 137 GALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD- 195 + + + Q+ + + + + +HRD+ N+L+ + ++K+ DFG ++ Sbjct: 135 NKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLV-ESEHQVKIGDFGLTKAIETD 193 Query: 196 ----TVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-------------- 237 TV D D + PE + +++ ++ VWS G+ L++++ Sbjct: 194 KEYYTVKDDRDSPVFWYAPECLMQSKFYI-ASDVWSFGVTLHELLTYCDSDSSPMALFLK 252 Query: 238 --GDIPFEHDEEIIR--------GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 G P + R ++ E L+R C +PS+R +F+ + Sbjct: 253 MIG--PTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIE 309 >5TOS-A nrPDB Length = 395 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 68/324 (20%), Positives = 125/324 (38%), Gaps = 56/324 (17%) Query: 8 SLAHLRAAPCNDLHAT--KLAPGKEKEPLESQYQVGPLLGSGGFGSVYSG---------I 56 ++A + L +T K E + ++ ++G GGFG V+ G Sbjct: 35 TVAAAQKTEGEILSSTPVKSFTFNELKLATRNFRPDSVIGEGGFGCVFKGWLDESTLTPT 94 Query: 57 RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSF 116 + L +A+K + ++ E E+ L ++S +++L+ + + Sbjct: 95 KPGTGLVIAVKKLNQEGFQGHREW------LTEINYLGQLSH--PNLVKLIGYCLEDEHR 146 Query: 117 VLILERPEPVQDLFDFITERG----ALQEELARSFFWQVLEAVRHCHN--CGVLHRDIKD 170 +L+ E + L + + RG L L + + + H+ V++RDIK Sbjct: 147 LLVYEFMQK-GSLENHLFRRGAYFKPLPWFLRVNVALDAAKGLAFLHSDPVKVIYRDIKA 205 Query: 171 ENILIDLNRGELKLIDFGSGAL--LKDTVY--TDFDGTRVYSPPEWIRYHRYHGRSAAVW 226 NIL+D + KL DFG + D Y T GT Y+ PE++ + RS V+ Sbjct: 206 SNILLDADYN-AKLSDFGLARDGPMGDLSYVSTRVMGTYGYAAPEYMSSGHLNARS-DVY 263 Query: 227 SLGILLYDMVCGD------------------IPFEHDEE---IIRGQVFFRQRVSSECQH 265 S G+LL +++ G P+ + +I Q + E Sbjct: 264 SFGVLLLEILSGKRALDHNRPAKEENLVDWARPYLTSKRKVLLIVDNRLDTQYLPEEAVR 323 Query: 266 LIR---WCLALRPSDRPTFEEIQN 286 + CL+ P RPT +++ Sbjct: 324 MASVAVQCLSFEPKSRPTMDQVVR 347 >1U54-B nrPDB Length = 291 Score = 178 bits (451), Expect = 4e-45, Method: Composition-based stats. Identities = 59/265 (22%), Positives = 103/265 (38%), Gaps = 27/265 (10%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIR-VSDNLPV--AIKHVEKDRISDWGELPNGTRVPMEVV 91 E ++ LG G FG V G V A+K ++ D +S + + EV Sbjct: 17 EKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDD---FIREVN 73 Query: 92 LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER-GALQEELARSFFWQ 150 + + +IRL P ++ E P+ L D + + G + Q Sbjct: 74 AMHSLDHR--NLIRLYGVVLTPP-MKMVTELA-PLGSLLDRLRKHQGHFLLGTLSRYAVQ 129 Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYT---DFDGTR 205 V E + + + +HRD+ N+L+ R +K+ DFG L D Y Sbjct: 130 VAEGMGYLESKRFIHRDLAARNLLL-ATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPF 188 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHD--EEIIR-----GQVFFRQ 257 + PE ++ + ++ W G+ L++M G P+ +I+ G+ R Sbjct: 189 AWCAPESLKTRTF-SHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRP 247 Query: 258 -RVSSECQHLIRWCLALRPSDRPTF 281 + +++ C A +P DRPTF Sbjct: 248 EDCPQDIYNVMVQCWAHKPEDRPTF 272 >4X3F-A nrPDB Length = 337 Score = 177 bits (450), Expect = 4e-45, Method: Composition-based stats. Identities = 63/260 (24%), Positives = 104/260 (40%), Gaps = 23/260 (8%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 L +Y++ L+ +GG G V+ + VA+K ++ + SD + R E Sbjct: 10 LSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFI---ERFRAEARTT 66 Query: 94 KKVSSGFSGVIRLLDWFE-----RPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 148 ++ G+ + D+ E + L++E + L + G L A Sbjct: 67 AMLNH--PGIASVHDYGESQMNGEGRTAYLVMELVNG-EPLNSVLKRTGRLSLRHALDML 123 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD---GTR 205 Q A++ H G++HRD+K NILI G++K+ DFG + T GT Sbjct: 124 EQTGRALQIAHAAGLVHRDVKPGNILITPT-GQVKITDFGIAKAVDAAPVTQTGMVMGTA 182 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-------EEIIRGQVFFRQR 258 Y PE H ++ V+SLG++ Y+ V G PF D + I Sbjct: 183 QYIAPEQALGHD-ASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPD 241 Query: 259 VSSECQHLIRWCLALRPSDR 278 + + LI L P+ R Sbjct: 242 LPPNVRELIEITLVKNPAMR 261 >4OW8-A nrPDB Length = 283 Score = 177 bits (450), Expect = 4e-45, Method: Composition-based stats. Identities = 63/260 (24%), Positives = 104/260 (40%), Gaps = 23/260 (8%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 L +Y++ L+ +GG G V+ + VA+K ++ + SD + R E Sbjct: 9 LSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFI---ERFRAEARTT 65 Query: 94 KKVSSGFSGVIRLLDWFE-----RPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 148 ++ G+ + D+ E + L++E + L + G L A Sbjct: 66 AMLNH--PGIASVHDYGESQMNGEGRTAYLVMELVNG-EPLNSVLKRTGRLSLRHALDML 122 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD---GTR 205 Q A++ H G++HRD+K NILI G++K+ DFG + T GT Sbjct: 123 EQTGRALQIAHAAGLVHRDVKPGNILITPT-GQVKITDFGIAKAVDAAPVTQTGMVMGTA 181 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-------EEIIRGQVFFRQR 258 Y PE H ++ V+SLG++ Y+ V G PF D + I Sbjct: 182 QYIAPEQALGHD-ASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPD 240 Query: 259 VSSECQHLIRWCLALRPSDR 278 + + LI L P+ R Sbjct: 241 LPPNVRELIEITLVKNPAMR 260 >6B2Q-A nrPDB Length = 317 Score = 177 bits (450), Expect = 5e-45, Method: Composition-based stats. Identities = 63/260 (24%), Positives = 104/260 (40%), Gaps = 23/260 (8%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 L +Y++ L+ +GG G V+ + VA+K ++ + SD + R E Sbjct: 30 LSGRYRLQRLIATGGMGQVWEAVDNRLGRRVAVKVLKSEFSSDPEFI---ERFRAEARTT 86 Query: 94 KKVSSGFSGVIRLLDWFE-----RPDSFVLILERPEPVQDLFDFITERGALQEELARSFF 148 ++ G+ + D+ E + L++E + L + G L A Sbjct: 87 AMLNH--PGIASVHDYGESQMNGEGRTAYLVMELVNG-EPLNSVLKRTGRLSLRHALDML 143 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD---GTR 205 Q A++ H G++HRD+K NILI G++K+ DFG + T GT Sbjct: 144 EQTGRALQIAHAAGLVHRDVKPGNILITPT-GQVKITDFGIAKAVDAAPVTQTGMVMGTA 202 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD-------EEIIRGQVFFRQR 258 Y PE H ++ V+SLG++ Y+ V G PF D + I Sbjct: 203 QYIAPEQALGHD-ASPASDVYSLGVVGYEAVSGKRPFAGDGALTVAMKHIKEPPPPLPPD 261 Query: 259 VSSECQHLIRWCLALRPSDR 278 + + LI L P+ R Sbjct: 262 LPPNVRELIEITLVKNPAMR 281 >2WO6-A nrPDB Length = 382 Score = 177 bits (450), Expect = 5e-45, Method: Composition-based stats. Identities = 58/231 (25%), Positives = 98/231 (42%), Gaps = 20/231 (8%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 K E +Y++ L+G G FG V + VAIK ++ + + + Sbjct: 47 KNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAF-------LNQAQI 99 Query: 89 EVVLL----KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEE 142 EV LL K + ++ L F + L+ E +L+D + + Sbjct: 100 EVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLS--YNLYDLLRNTNFRGVSLN 157 Query: 143 LARSFFWQVLEAVRHCH--NCGVLHRDIKDENILI-DLNRGELKLIDFGSGALLKDTVYT 199 L R F Q+ A+ ++H D+K ENIL+ + R +K++DFGS L +Y Sbjct: 158 LTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIY- 216 Query: 200 DFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIR 250 + +R Y PE + Y + +WSLG +L +M G+ F E+ + Sbjct: 217 QYIQSRFYRSPEVLLGMPY-DLAIDMWSLGCILVEMHTGEPLFSGANEVDQ 266 Score = 37.2 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 6/31 (19%), Positives = 9/31 (29%) Query: 263 CQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 + LI L P R H + + Sbjct: 349 FKDLILRMLDYDPKTRIQPYYALQHSFFKKT 379 >5TE0-A nrPDB Length = 347 Score = 177 bits (449), Expect = 6e-45, Method: Composition-based stats. Identities = 74/302 (24%), Positives = 121/302 (40%), Gaps = 39/302 (12%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 Q V +L GGF V+ +R S+ + A+K + + D E+ +++ + Sbjct: 20 QVTVDEVLAEGGFAIVFL-VRTSNGMKCALKRMFVNNEHDLQV------CKREIQIMRDL 72 Query: 97 SSGFSGVIRLLDW----FERPD--SFVLILERPEPVQ--DLFDFITERGALQEELARSFF 148 S G ++ +D D +++++ Q +L + + G E F Sbjct: 73 S-GHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG-FTENEVLQIF 130 Query: 149 WQVLEAVRHCHNCG--VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDG--- 203 EAV H C ++HRD+K ENIL+ +RG L DFGS T+ Sbjct: 131 CDTCEAVARLHQCKTPIIHRDLKVENILL-HDRGHYVLCDFGSATNKFQNPQTEGVNAVE 189 Query: 204 -------TRVYSPPEWIR--YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE-EIIRGQV 253 T Y PE + + A +W+LG LLY + +PF + I G Sbjct: 190 DEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNF 249 Query: 254 FFRQ--RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGP 311 R S + LIR+ L P RP ++ + LL +E ++ + SP P Sbjct: 250 TIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQV---SYFSFKLLKKECPIPNVQN-SPIP 305 Query: 312 SK 313 +K Sbjct: 306 AK 307 >6EII-A nrPDB Length = 352 Score = 177 bits (449), Expect = 6e-45, Method: Composition-based stats. Identities = 64/303 (21%), Positives = 113/303 (37%), Gaps = 61/303 (20%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 + YQ+ LG G + V+ I +++N + + ++ E+ +L+ Sbjct: 59 QDDYQLVRKLGRGKYSEVFEAINITNNEK---------VVVKILKPVKKKKIKREIKILE 109 Query: 95 KVSSGFSGVIRLLDWFERPDSFV--LILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 + G +I L D + P S L+ E DF L + R + +++L Sbjct: 110 NLRGG-PNIITLADIVKDPVSRTPALVFEHVNNT----DFKQLYQTLTDYDIRFYMYEIL 164 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRVYSPPE 211 +A+ +CH+ G++HRD+K N++ID +L+LID+G Y +R + PE Sbjct: 165 KALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPE 224 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE--------------------IIRG 251 + ++ + S +WSLG +L M+ PF H + I + Sbjct: 225 LLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKY 284 Query: 252 QVFFRQR------------------------VSSECQHLIRWCLALRPSDRPTFEEIQNH 287 + R VS E + L R T E H Sbjct: 285 NIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEH 344 Query: 288 PWM 290 P+ Sbjct: 345 PYF 347 >4YFF-A nrPDB Length = 311 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 58/263 (22%), Positives = 102/263 (38%), Gaps = 22/263 (8%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 S+ + ++GSG FG VY G N VAIK + ++ EV +L + Sbjct: 42 SEIEFHEIIGSGSFGKVYKGRCR--NKIVAIKRYRANTYCSKSDVDM---FCREVSILCQ 96 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFW-QVLEA 154 ++ VI+ + S I+ + LF + E+ + + ++ V + Sbjct: 97 LNH--PCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKG 154 Query: 155 VRHCHN--CGVLHRDIKDENILIDLNRGELKLIDFGSGALLK---DTVYTDFDGTRVYSP 209 + + HN ++HRD+ NIL+ G + DFG L+ + T G + Sbjct: 155 MEYLHNLTQPIIHRDLNSHNILL-YEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRWMA 213 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEII----RGQVFFRQR----VSS 261 PE + A V+S + L++++ G+IPF H + R + Sbjct: 214 PEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPK 273 Query: 262 ECQHLIRWCLALRPSDRPTFEEI 284 L+ P RP F E+ Sbjct: 274 PISSLLIRGWNACPEGRPEFSEV 296 >2PVN-A nrPDB Length = 352 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 67/306 (21%), Positives = 115/306 (37%), Gaps = 61/306 (19%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 + Y+V +G G + V+ GI V++N I + ++ E+ +L+ Sbjct: 51 QDDYEVVRKVGRGKYSEVFEGINVNNNEKC---------IIKILKPVKKKKIKREIKILQ 101 Query: 95 KVSSGFSGVIRLLDWFERPDSFV--LILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 + G +++LLD S LI E DF L + R + +++L Sbjct: 102 NL-CGGPNIVKLLDIVRDQHSKTPSLIFEYVNNT----DFKVLYPTLTDYDIRYYIYELL 156 Query: 153 EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRVYSPPE 211 +A+ +CH+ G++HRD+K N++ID +L+LID+G Y +R + PE Sbjct: 157 KALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPE 216 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE-----HDEEIIRGQVFFRQR-------- 258 + + + S +WSLG + M+ PF HD+ + +V Sbjct: 217 LLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNAYLNKY 276 Query: 259 -------------------------------VSSECQHLIRWCLALRPSDRPTFEEIQNH 287 VS E + L +R T E H Sbjct: 277 RIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTH 336 Query: 288 PWMQDV 293 P+ Q V Sbjct: 337 PYFQQV 342 >5U6B-A nrPDB Length = 307 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 59/273 (21%), Positives = 104/273 (38%), Gaps = 33/273 (12%) Query: 40 VGPLLGSGGFGSVYSGIRVSDN--LPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 +G LG G FG+V G D+ L VA+K + K I EL + E V +K+ Sbjct: 27 LGKTLGEGEFGAVMEGQLNQDDSILKVAVKTM-KIAICTRSELED---FLSEAVCMKEFD 82 Query: 98 SGFSGVIRLLDWFERPDSF-----VLILERPEPVQDLFDFI------TERGALQEELARS 146 V+RL+ + +++ DL F+ + L ++ Sbjct: 83 H--PNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVK 140 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV 206 F + + + +HRD+ N +++ N + DFG + + Y G Sbjct: 141 FMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVC-VADFGLSKKIYNGDYY-RQGRIA 198 Query: 207 YSPPEWIRYH----RYHGRSAAVWSLGILLYDMVC-GDIPFEH--DEEIIR-----GQVF 254 P +WI R + + VWS G+ ++++ G P+ + EI ++ Sbjct: 199 KMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLK 258 Query: 255 FRQRVSSECQHLIRWCLALRPSDRPTFEEIQNH 287 L+ C L P DRP+F E++ Sbjct: 259 QPADCLDGLYALMSRCWELNPQDRPSFTELRED 291 >3RAW-A nrPDB Length = 381 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 69/345 (20%), Positives = 116/345 (33%), Gaps = 87/345 (25%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNL-PVAIKHVEKDRISDWGELPNGTRVPME 89 + L+ +Y++ LG G FG V + + VA+K + +E Sbjct: 46 GDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIR-------NVGKYREAARLE 98 Query: 90 VVLLKKVSSGFSG----VIRLLDWFERPDSFVLILERPEPVQDLFDFITER--GALQEEL 143 + +LKK+ + + DWF + E + F+F+ E Sbjct: 99 INVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGK--NTFEFLKENNFQPYPLPH 156 Query: 144 ARSFFWQVLEAVRHCHNCGVLHRDIKDENILI------------------DLNRGELKLI 185 R +Q+ A+R H + H D+K ENIL + +++ Sbjct: 157 VRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVA 216 Query: 186 DFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD 245 DFGS +T TR Y PPE I + + VWS+G +L++ G F+ Sbjct: 217 DFGSATF-DHEHHTTIVATRHYRPPEVILELGW-AQPCDVWSIGCILFEYYRGFTLFQTH 274 Query: 246 EE---------------------IIRGQVFFR------------QRVSSECQ-------- 264 E + + F++ + V C+ Sbjct: 275 ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQ 334 Query: 265 ---------HLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA 300 L+R L P+ R T E HP+ L P+E + Sbjct: 335 DSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFA-GLTPEERS 378 >5UNP-A nrPDB Length = 369 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 63/335 (18%), Positives = 116/335 (34%), Gaps = 86/335 (25%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGI-RVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 89 + L+ +Y++ LG G FG V + VA+K ++ +E Sbjct: 29 GDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIK-------NVEKYKEAARLE 81 Query: 90 VVLLKKVSSGFSG----VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEE--L 143 + +L+K++ +++ DWF+ + E FDF+ + L Sbjct: 82 INVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLG--LSTFDFLKDNNYLPYPIHQ 139 Query: 144 ARSFFWQVLEAVRHCHNCGVLHRDIKDENILI------------------DLNRGELKLI 185 R +Q+ +AV+ H+ + H D+K ENIL + ++++ Sbjct: 140 VRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVV 199 Query: 186 DFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD 245 DFGS ++ TR Y PE I + + VWS+G ++++ G F+ Sbjct: 200 DFGSATF-DHEHHSTIVSTRHYRAPEVILELGW-SQPCDVWSIGCIIFEYYVGFTLFQTH 257 Query: 246 E---------------------EIIRGQVFFR------------QRVSSECQ-------- 264 + + + + F+R + V C+ Sbjct: 258 DNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTS 317 Query: 265 ---------HLIRWCLALRPSDRPTFEEIQNHPWM 290 LI L P+ R T E HP+ Sbjct: 318 EAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFF 352 >4NEU-A nrPDB Length = 333 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 60/292 (20%), Positives = 108/292 (36%), Gaps = 40/292 (13%) Query: 46 SGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIR 105 SGGFG V + L + K + + + E ++ ++ V++ Sbjct: 34 SGGFGKVSLCFHRTQGL-----MIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSR--VVK 86 Query: 106 LLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLH 165 LL + L++E E +L + + + +++E + + H GV+H Sbjct: 87 LLGVIIEEGKYSLVMEYMEK-GNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIH 145 Query: 166 RDIKDENILIDLNRGELKLIDFGSGAL---------------LKDTVYTDFDGTRVYSPP 210 +D+K ENIL+D N +K+ D G + D GT Y P Sbjct: 146 KDLKPENILVD-NDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAP 204 Query: 211 EWIRY-HRYHGRSAAVWSLGILLYDMVCGDIPFEH-------DEEIIRGQV----FFRQR 258 E + + + V+S ++L+ + P+E+ I G + Sbjct: 205 EHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEY 264 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQNH--PWMQDVLLPQETAEIHLHSLS 308 E L++ C P RPTF I+ P+ L +E+ E + SL Sbjct: 265 CPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQL--EESVEEDVKSLK 314 >4IDT-A nrPDB Length = 356 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 59/286 (20%), Positives = 99/286 (34%), Gaps = 50/286 (17%) Query: 44 LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGV 103 LG G FG V+ A+K V + L+ + Sbjct: 82 LGRGSFGEVHRMEDKQTGFQCAVKKVRLEVFRAEE-------------LMACAGLTSPRI 128 Query: 104 IRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGV 163 + L + +E E L + E+G L E+ A + Q LE + + H+ + Sbjct: 129 VPLYGAVREGPWVNIFMELLEG-GSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRI 187 Query: 164 LHRDIKDENILIDLNRGELKLIDFGSGALL------KDTVYTDFD-GTRVYSPPEWIRYH 216 LH D+K +N+L+ + L DFG L KD + D+ GT + PE + Sbjct: 188 LHGDVKADNVLLSSDGSHAALCDFGHAVCLQPDGLGKDLLTGDYIPGTETHMAPEVVLGR 247 Query: 217 RYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR--------QRVSSECQHL-- 266 + VWS ++ M+ G P+ + RG + + + + C L Sbjct: 248 SCDAK-VDVWSSCCMMLHMLNGCHPW---TQFFRGPLCLKIASEPPPVREIPPSCAPLTA 303 Query: 267 --IRWCLALRPSDRPTFEEI-------------QNHPWMQDVLLPQ 297 I+ L P R + E+ PW + P+ Sbjct: 304 QAIQEGLRKEPIHRVSAAELGGKVNRALQQVGGLKSPWRGEYKEPR 349 >5TQX-A nrPDB Length = 655 Score = 174 bits (442), Expect = 4e-44, Method: Composition-based stats. Identities = 55/232 (23%), Positives = 101/232 (43%), Gaps = 20/232 (8%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 +++ LG+GGFG+V +L +AIK + + N R E+ ++KK++ Sbjct: 10 WEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTK-----NRERWCHEIQIMKKLN 64 Query: 98 SGFSGVIRLLDWFERPDSFV-----LILERPEPVQDLFDFITER---GALQEELARSFFW 149 V++ D E + + L +E DL + + L+E S Sbjct: 65 HA--NVVKACDVPEELNILIHDVPLLAMEYCSG-GDLRKLLNKPENCCGLKESQILSLLS 121 Query: 150 QVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL--KLIDFGSGALL-KDTVYTDFDGTRV 206 + +R+ H ++HRD+K ENI++ G++ K+ID G + + + T+F GT Sbjct: 122 DIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGELCTEFVGTLQ 181 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR 258 Y PE Y WS G ++++ + G PF H + +++ Sbjct: 182 YLAPELFENKPYTAT-VDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKK 232 >6CTH-A nrPDB Length = 309 Score = 173 bits (440), Expect = 6e-44, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 116/313 (37%), Gaps = 49/313 (15%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPME 89 E + S + LG GGFGSVY G + +A+K V + E + E Sbjct: 9 ELAKVTSNFNAENKLGEGGFGSVYRGFLRDSDTYIAVKKVSRASKQGIKEYAS------E 62 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARS-FF 148 V ++ ++ +++L+ W +L+ E L I + +L R Sbjct: 63 VKIISRLRH--KNLVKLIGWCHERGELMLVYEFMAN-GSLDSHIFKGKSLLTWEVRYRIV 119 Query: 149 WQVLEAVRHCHNCG---VLHRDIKDENILIDLNRGELKLIDFGSGALL---KDTVYTDFD 202 + A+ + H G VLHRDIK NI++D + KL DFG L+ K T Sbjct: 120 KDLASALLYLHEEGDHCVLHRDIKTSNIMLDSSFN-AKLGDFGLARLVDHAKGLKKTLLA 178 Query: 203 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCG----DIPFEHDEEIIRGQVFFRQR 258 GT Y PE + + + + V+S G++ ++ G + FE E ++ + Sbjct: 179 GTVGYMAPECLSSGK-ASKESDVYSFGVVALEIASGRRSIEPKFEESEALLLVPWVWESY 237 Query: 259 VSSECQHL------------------IRWCLALRPSD--RPTFEEIQNHPWMQDVLLPQE 298 + + + PS RP+ ++ +Q + E Sbjct: 238 GNERILDIADRKLGMAFDPKQLECLVMVGLWCAHPSHNLRPSIRQV-----IQVLNF--E 290 Query: 299 TAEIHLHSLSPGP 311 +L P P Sbjct: 291 APLPNLPGSMPIP 303 >1S9I-A nrPDB Length = 354 Score = 173 bits (440), Expect = 6e-44, Method: Composition-based stats. Identities = 62/319 (19%), Positives = 116/319 (36%), Gaps = 65/319 (20%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 K E + ++ LG+G G V L +A K + + ++ Sbjct: 8 AKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAI-----RNQII 62 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSF 147 E+ +L + +S + ++ F + +E + L + E + EE+ Sbjct: 63 RELQVLHECNSPY--IVGFYGAFYSDGEISICMEHMDG-GSLDQVLKEAKRIPEEILGKV 119 Query: 148 FWQVLEAVRHC-HNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV 206 VL + + ++HRD+K NIL++ RGE+KL DFG L D++ F GTR Sbjct: 120 SIAVLRGLAYLREKHQIMHRDVKPSNILVNS-RGEIKLCDFGVSGQLIDSMANSFVGTRS 178 Query: 207 YSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE----------IIRGQVFFR 256 Y PE ++ Y +S +WS+G+ L ++ G P + ++ G+ Sbjct: 179 YMAPERLQGTHYSVQS-DIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDGEEGEP 237 Query: 257 QRVS--------------------------------------------SECQHLIRWCLA 272 +S + Q + CL Sbjct: 238 HSISPRPRPPGRPVSGHGMDSRPAMAIFELLDYIVNEPPPKLPNGVFTPDFQEFVNKCLI 297 Query: 273 LRPSDRPTFEEIQNHPWMQ 291 P++R + + NH +++ Sbjct: 298 KNPAERADLKMLTNHTFIK 316 >2W1I-A nrPDB Length = 326 Score = 173 bits (439), Expect = 9e-44, Method: Composition-based stats. Identities = 50/291 (17%), Positives = 101/291 (34%), Gaps = 46/291 (15%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRV----SDNLPVAIKHVEKDRISDWGELPNGT 84 + E + LG G FGSV + VA+K + + Sbjct: 34 DPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL------QHSTEEHLR 87 Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERPD--SFVLILERPEPVQDLFDFITERG-ALQE 141 E+ +LK + +++ + LI+E P L D++ + + Sbjct: 88 DFEREIEILKSLQHD--NIVKYKGVCYSAGRRNLKLIMEYL-PYGSLRDYLQKHKERIDH 144 Query: 142 ELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDF 201 + Q+ + + + +HRD+ NIL+ N +K+ DFG +L Sbjct: 145 IKLLQYTSQICKGMEYLGTKRYIHRDLATRNILV-ENENRVKIGDFGLTKVLPQDKEYYK 203 Query: 202 DGTR-----VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC------------------- 237 + PE + ++ ++ VWS G++LY++ Sbjct: 204 VKEPGESPIFWYAPESLTESKF-SVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGND 262 Query: 238 --GDIPFEHDEEIIR--GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEI 284 G + H E+++ G++ E ++ C + RP+F ++ Sbjct: 263 KQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 313 >3QUP-A nrPDB Length = 323 Score = 172 bits (437), Expect = 1e-43, Method: Composition-based stats. Identities = 53/286 (18%), Positives = 103/286 (36%), Gaps = 41/286 (14%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDN---LPVAIKHVEKDRISDWGELPNGTRVPMEVV 91 E Q+ +G +LG G FGSV ++ + VA+K ++ D I+ + E Sbjct: 22 EQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIAS----SDIEEFLREAA 77 Query: 92 LLKKVSSGFSGVIRLLDWFERPD-----SFVLILERPEPVQDLFDFI------TERGALQ 140 +K+ V +L+ R +++ DL F+ L Sbjct: 78 CMKEFDH--PHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLP 135 Query: 141 EELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA-LLKDTVYT 199 + F + + + + +HRD+ N ++ + + DFG + Y Sbjct: 136 LQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVC-VADFGLSRKIYSGDYYR 194 Query: 200 DFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEE-------I 248 +++ + E + + Y S VW+ G+ +++++ G P+ E I Sbjct: 195 QGCASKLPVKWLALESLADNLYTVHS-DVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLI 253 Query: 249 IRGQVFFRQRVSSECQHLIRWCLALRPSDRPTF-------EEIQNH 287 ++ E L+ C + P RP+F E I H Sbjct: 254 GGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGH 299 >5XVU-A nrPDB Length = 332 Score = 172 bits (437), Expect = 1e-43, Method: Composition-based stats. Identities = 67/305 (21%), Positives = 122/305 (40%), Gaps = 61/305 (20%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 ++Y++ +G G + V++G N P A + ++ E+ +L+ Sbjct: 31 NRYEIMKKIGRGKYSEVFNGYDTECNRPCA---------IKVLKPVKKKKIKREIKILQN 81 Query: 96 VSSGFSGVIRLLDWFERP--DSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 ++ G +I+LLD + P + LI E + DF T ++ R + +Q+L+ Sbjct: 82 LNGG-PNIIKLLDIVKDPVTKTPSLIFEYINNI----DFKTLYPKFTDKDIRYYIYQILK 136 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTVYTDFDGTRVYSPPEW 212 A+ +CH+ G++HRD+K NI+ID +++LI +G Y +R Y PE Sbjct: 137 ALDYCHSQGIMHRDVKPHNIMIDHENRQIRLISWGLAEFYHPGQEYNVRVASRYYKGPEL 196 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFE-----HDEEIIRGQVF------------- 254 + + + S +WSLG +L M+ PF +D+ + +V Sbjct: 197 LIDLQLYDYSLDIWSLGCMLAGMIFKKEPFFCGHDNYDQLVKIAKVLGTEDLHAYLKKYN 256 Query: 255 --------------FRQRVS------------SECQHLIRWCLALRPSDRPTFEEIQNHP 288 R+ S E LI L + R +E HP Sbjct: 257 IKLKPHYLNILGEYERKPWSHFLTQSNIDIAKDEVIDLIDKMLIYDHAKRIAPKEAMEHP 316 Query: 289 WMQDV 293 + ++V Sbjct: 317 YFREV 321 >4Y83-A nrPDB Length = 332 Score = 172 bits (436), Expect = 2e-43, Method: Composition-based stats. Identities = 61/269 (22%), Positives = 97/269 (36%), Gaps = 35/269 (13%) Query: 46 SGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIR 105 G FG VY + +A K + D+ +E+ + + Sbjct: 83 RGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSD---------VEIQACFR----HENIAE 129 Query: 106 LLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLH 165 L ++ L +E E + + + G ++E VL+ + H+ V+H Sbjct: 130 LYGAVLWGETVHLFMEAGEG-GSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIH 188 Query: 166 RDIKDENILIDLNRGELKLIDFGSGALLKDTVY--TDFDGTRVYSPPEWIRYHRYHGRSA 223 DIK NI+ + L+DFG + + VY D GT +Y PE I R H A Sbjct: 189 HDIKPSNIVFMSTKAV--LVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILC-RGHSTKA 245 Query: 224 AVWSLGILLYDMVCGDIP---------FEHDEEIIRGQ----VFFRQRVSSECQHLIRWC 270 ++SLG L M G P + II Q S + LI Sbjct: 246 DIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEAS 305 Query: 271 LALRPSDRPTFEEIQNHPWMQDVLLPQET 299 L P+ RP ++ H + + P+E Sbjct: 306 LERNPNHRPRAADLLKH---EALNPPRED 331 >3IO7-A nrPDB Length = 313 Score = 171 bits (435), Expect = 2e-43, Method: Composition-based stats. Identities = 50/288 (17%), Positives = 101/288 (35%), Gaps = 46/288 (15%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRV----SDNLPVAIKHVEKDRISDWGELPNGTRVP 87 + E + LG G FGSV + VA+K + + Sbjct: 24 QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKL------QHSTEEHLRDFE 77 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPD--SFVLILERPEPVQDLFDFITERG-ALQEELA 144 E+ +LK + +++ + LI+E P L D++ + + Sbjct: 78 REIEILKSLQHD--NIVKYKGVCYSAGRRNLKLIMEYL-PYGSLRDYLQKHKERIDHIKL 134 Query: 145 RSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGT 204 + Q+ + + + +HRD+ NIL+ N +K+ DFG +L Sbjct: 135 LQYTSQICKGMEYLGTKRYIHRDLATRNILV-ENENRVKIGDFGLTKVLPQDKEYYKVKE 193 Query: 205 R-----VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC---------------------G 238 + PE + ++ ++ VWS G++LY++ G Sbjct: 194 PGESPIFWYAPESLTESKF-SVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQG 252 Query: 239 DIPFEHDEEIIR--GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEI 284 + H E+++ G++ E ++ C + RP+F ++ Sbjct: 253 QMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDL 300 >3AOX-A nrPDB Length = 344 Score = 171 bits (435), Expect = 2e-43, Method: Composition-based stats. Identities = 59/282 (20%), Positives = 103/282 (36%), Gaps = 35/282 (12%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGI-----RVSDNLPVAIKHVEKDRISDWGELPNGTR 85 KE + LG G FG VY G L VA+K + + S+ EL Sbjct: 42 KEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTL-PEVCSEQDELD---- 96 Query: 86 VPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA------- 138 ME +++ K + ++R + + ++LE DL F+ E Sbjct: 97 FLMEALIISKFNHQ--NIVRCIGVSLQSLPRFILLELMAG-GDLKSFLRETRPRPSQPSS 153 Query: 139 LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILID--LNRGELKLIDFGSGALLKDT 196 L + ++ +HRDI N L+ K+ DFG + Sbjct: 154 LAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRA 213 Query: 197 VYTDFDGTRV----YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH--DEEII 249 Y G + + PPE + ++ WS G+LL+++ G +P+ ++E++ Sbjct: 214 SYYRKGGCAMLPVKWMPPEAFMEGIFTSKT-DTWSFGVLLWEIFSLGYMPYPSKSNQEVL 272 Query: 250 R-----GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 G++ + ++ C +P DRP F I Sbjct: 273 EFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILE 314 >6FER-A nrPDB Length = 309 Score = 171 bits (434), Expect = 3e-43, Method: Composition-based stats. Identities = 59/300 (19%), Positives = 102/300 (34%), Gaps = 56/300 (18%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSG--------------IRVSDNLPV--AIKHVEKDRI 74 +E LG G FG V+ + VS N PV A+K + D Sbjct: 4 EEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRAD-- 61 Query: 75 SDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT 134 E+ ++ ++ +I LL D +I E E DL F++ Sbjct: 62 ---ANKNARNDFLKEIKIMSRLK--DPNIIHLLAVCITDDPLCMITEYMEN-GDLNQFLS 115 Query: 135 ER----------GALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKL 184 + + Q+ +++ + +HRD+ N L+ N +K+ Sbjct: 116 RHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNY-TIKI 174 Query: 185 IDFGSGALLKDTVYTDFDG----TRVYSPPEWIRYHRYHGRSAAVWSLGILLYD--MVCG 238 DFG L Y G + E I ++ ++ VW+ G+ L++ C Sbjct: 175 ADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTT-ASDVWAFGVTLWETFTFCQ 233 Query: 239 DIPFEH--DEEIIRGQVFF------------RQRVSSECQHLIRWCLALRPSDRPTFEEI 284 + P+ DE++I F L+ C +RP+F+EI Sbjct: 234 EQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEI 293 >5UIU-A nrPDB Length = 323 Score = 171 bits (434), Expect = 4e-43, Method: Composition-based stats. Identities = 60/274 (21%), Positives = 98/274 (35%), Gaps = 38/274 (13%) Query: 41 GPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGF 100 G +G GGFG VY G +N VA+K + + D + E+ ++ K Sbjct: 52 GNKMGEGGFGVVYKGY--VNNTTVAVKKL--AAMVDITTEELKQQFDQEIKVMAKCQH-- 105 Query: 101 SGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE---RGALQEELARSFFWQVLEAVRH 157 ++ LL + D L+ P L D ++ L + + Sbjct: 106 ENLVELLGFSSDGDDLCLVYVYM-PNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINF 164 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA---LLKDTVYTDF-DGTRVYSPPEWI 213 H +HRDIK NIL+D K+ DFG TV T GT Y PE + Sbjct: 165 LHENHHIHRDIKSANILLD-EAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL 223 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEI--------------------IRGQV 253 R + ++S G++L +++ G + E I ++ Sbjct: 224 RGE--ITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKM 281 Query: 254 FFRQRVSSEC-QHLIRWCLALRPSDRPTFEEIQN 286 S E + CL + + RP +++Q Sbjct: 282 NDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQ 315 >4HVI-A nrPDB Length = 314 Score = 170 bits (432), Expect = 6e-43, Method: Composition-based stats. Identities = 64/278 (23%), Positives = 105/278 (37%), Gaps = 51/278 (18%) Query: 44 LGSGGFGSVYSGIRV----SDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 99 LG G FGSV + VA+K ++ + E+ +LK + S Sbjct: 18 LGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRD------FQREIQILKALHSD 71 Query: 100 FSGVIRLLDWFERPD--SFVLILERPEPVQDLFDFI-TERGALQEELARSFFWQVLEAVR 156 F +++ P S L++E P L DF+ R L + Q+ + + Sbjct: 72 F--IVKYRGVSYGPGRQSLRLVMEYL-PSGCLRDFLQRHRARLDASRLLLYSSQICKGME 128 Query: 157 HCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL---KDTVYTDFDG--TRVYSPPE 211 + + +HRD+ NIL+ + +K+ DFG LL KD G + PE Sbjct: 129 YLGSRRCVHRDLAARNILV-ESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPE 187 Query: 212 WIRYHRYHGRSAAVWSLGILLYDMVC----GDIPFEHDEEIIR----------------- 250 + + + R + VWS G++LY++ P E +R Sbjct: 188 SLSDNIF-SRQSDVWSFGVVLYELFTYCDKSCSP---SAEFLRMMGSERDVPALSRLLEL 243 Query: 251 ---GQVFF-RQRVSSECQHLIRWCLALRPSDRPTFEEI 284 GQ +E L++ C A P DRP+F + Sbjct: 244 LEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSAL 281 >3LMG-A nrPDB Length = 344 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 65/299 (21%), Positives = 134/299 (44%), Gaps = 34/299 (11%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNL----PVAIKHVE-KDRISDWGELPNGTRVPME 89 E++ + +LGSG FG+V+ G+ + + PV IK +E K + + + Sbjct: 30 ETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAI-- 87 Query: 90 VVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSFF 148 + ++RLL S L+ + P+ L D + + RGAL +L ++ Sbjct: 88 ----GSLDHAH--IVRLLGLC-PGSSLQLVTQYL-PLGSLLDHVRQHRGALGPQLLLNWG 139 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL----KDTVYTDFDGT 204 Q+ + + + G++HR++ N+L+ + ++++ DFG LL K +Y++ Sbjct: 140 VQIAKGMYYLEEHGMVHRNLAARNVLL-KSPSQVQVADFGVADLLPPDDKQLLYSEAKTP 198 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPF------EHDEEIIRGQVF-FR 256 + E I + +Y + VWS G+ +++++ G P+ E + + +G+ Sbjct: 199 IKWMALESIHFGKY-THQSDVWSYGVTVWELMTFGAEPYAGLRLAEVPDLLEKGERLAQP 257 Query: 257 QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHL---HSLSPGPS 312 Q + + ++ C + + RPTF+E+ N + + P I ++PGP Sbjct: 258 QICTIDVYMVMVKCWMIDENIRPTFKELAN-EFTRMARDPPRYLVIKRESGPGIAPGPE 315 >6J5U-C nrPDB Length = 426 Score = 169 bits (428), Expect = 2e-42, Method: Composition-based stats. Identities = 64/292 (21%), Positives = 111/292 (38%), Gaps = 52/292 (17%) Query: 35 ESQYQVGPLLGSGGFGSVYSG---------IRVSDNLPVAIKHVEKDRISDWGELPNGTR 85 ++ LLG GGFG V+ G R + VA+K ++ + E Sbjct: 83 TKNFRQDNLLGEGGFGCVFKGWIDQTSLTASRPGSGIVVAVKQLKPEGFQGHKEW----- 137 Query: 86 VPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG--ALQEEL 143 EV L ++S ++ L+ + ++ +L+ E P L + + RG L + Sbjct: 138 -LTEVNYLGQLSH--PNLVLLVGYCAEGENRLLVYEFM-PKGSLENHLFRRGAQPLTWAI 193 Query: 144 ARSFFWQVLEAVRHCHNCG--VLHRDIKDENILIDLNRGELKLIDFGSGALLKDT----V 197 + + H V++RD K NIL+D + KL DFG V Sbjct: 194 RMKVAVGAAKGLTFLHEAKSQVIYRDFKAANILLDADFN-AKLSDFGLAKAGPTGDNTHV 252 Query: 198 YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGD------------------ 239 T GT Y+ PE++ R +S V+S G++L +++ G Sbjct: 253 STKVIGTHGYAAPEYVATGRLTAKS-DVYSFGVVLLELISGRRAMDNSNGGNEYSLVDWA 311 Query: 240 IPFEHDE----EIIRGQVF--FRQRVSSECQHLIRWCLALRPSDRPTFEEIQ 285 P+ D+ I+ ++ + Q+ + +L CL RP E+ Sbjct: 312 TPYLGDKRKLFRIMDTKLGGQYPQKGAFTAANLALQCLNPDAKLRPKMSEVL 363 >2JD5-A nrPDB Length = 373 Score = 168 bits (427), Expect = 2e-42, Method: Composition-based stats. Identities = 77/347 (22%), Positives = 135/347 (38%), Gaps = 69/347 (19%) Query: 19 DLHATKLAPGKEKEPLES-QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDW 77 D P + EP + +Y + LG G F +V+ + +N VA+K V D++ Sbjct: 1 DYRPGGFHPAFKGEPYKDARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTE 60 Query: 78 GELPNGTRVPM--EVVLLKKVSSGFSGVIRLLDWFER--PDSFVLILERPEPVQDLFDFI 133 + + K+ S G + +++LLD F P+ +++ ++L I Sbjct: 61 AAEDEIKLLQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALI 120 Query: 134 T--ERGALQEELARSFFWQVLEAVRHCH-NCGVLHRDIKDENILID-----LNRGELKLI 185 E + + Q+L + + H CG++H DIK EN+L++ N ++K+ Sbjct: 121 KKYEHRGIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIA 180 Query: 186 DFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD 245 D G+ D YT+ TR Y PE + + G A +WS L+++++ GD FE D Sbjct: 181 DLGNA-CWYDEHYTNSIQTREYRSPEVLLGAPW-GCGADIWSTACLIFELITGDFLFEPD 238 Query: 246 E-----------------------EIIRGQVFFR---------QRVSS------------ 261 E ++R + R + +S Sbjct: 239 EGHSYTKDDDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTE 298 Query: 262 -------ECQ---HLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQE 298 E + + L L P R + NHPW++D L +E Sbjct: 299 KYKFSKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEE 345 >2A1A-B nrPDB Length = 284 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 64/271 (23%), Positives = 113/271 (41%), Gaps = 36/271 (13%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 ++ L+GSGGFG V+ D IK V+ N + EV L K+ Sbjct: 12 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIKRVK----------YNNEKAEREVKALAKL 61 Query: 97 SSGFSGVIRLLDWFERPDS----------------FVLILERPEPVQDLFDFITERGA-- 138 ++ ++ D + +E + L +I +R Sbjct: 62 DHV--NIVHYNGCWDGFDYDPETSSKNSSRSKTKCLFIQMEFCDK-GTLEQWIEKRRGEK 118 Query: 139 LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK-DTV 197 L + LA F Q+ + V + H+ +++RD+K NI + ++ ++K+ DFG LK D Sbjct: 119 LDKVLALELFEQITKGVDYIHSKKLINRDLKPSNIFL-VDTKQVKIGDFGLVTSLKNDGK 177 Query: 198 YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMV-CGDIPFEHDEEIIRGQVFFR 256 T GT Y PE I Y G+ +++LG++L +++ D FE + + Sbjct: 178 RTRSKGTLRYMSPEQISSQDY-GKEVDLYALGLILAELLHVCDTAFETSKFFTDLRDGII 236 Query: 257 QRV-SSECQHLIRWCLALRPSDRPTFEEIQN 286 + + + L++ L+ +P DRP EI Sbjct: 237 SDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 267 >4IAN-A nrPDB Length = 358 Score = 168 bits (426), Expect = 3e-42, Method: Composition-based stats. Identities = 61/240 (25%), Positives = 104/240 (43%), Gaps = 20/240 (8%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRV-SDNLPVAIKHVEKDRISDWGELPNGTRVPME 89 E L+ +Y V G G F +V N VA+K + + + L E Sbjct: 25 GEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLK-------E 77 Query: 90 VVLLKKVSSGFS----GVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG---ALQEE 142 + LKK++ +RL F L+ E +L + + + G L + Sbjct: 78 LEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLS--MNLREVLKKYGKDVGLHIK 135 Query: 143 LARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD 202 RS+ Q+ A++ C +LH DIK +NIL++ ++ LKL DFGS + + D T + Sbjct: 136 AVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYL 195 Query: 203 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH--DEEIIRGQVFFRQRVS 260 +R Y PE I Y +WS+G LY++ G I F + +++ + + ++ Sbjct: 196 VSRFYRAPEIIIGKSY-DYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMP 254 Score = 40.6 bits (94), Expect = 9e-04, Method: Composition-based stats. Identities = 7/30 (23%), Positives = 15/30 (50%) Query: 263 CQHLIRWCLALRPSDRPTFEEIQNHPWMQD 292 + L+ L L P+ R + + H ++Q+ Sbjct: 321 LKDLLDQILMLDPAKRISINQALQHAFIQE 350 >5IKW-A nrPDB Length = 310 Score = 168 bits (425), Expect = 4e-42, Method: Composition-based stats. Identities = 73/300 (24%), Positives = 111/300 (37%), Gaps = 34/300 (11%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 Q + L GGF +V+ +R + A+K + + + D E+ ++K++ Sbjct: 15 QVTLEESLAEGGFSTVFL-VRTHGGIRCALKRMYVNNMPDLNV------CKREITIMKEL 67 Query: 97 SSGFSGVIRLLDW----FERPDSFVLILERPEPVQDLFDFITER--GALQEELARSFFWQ 150 S G ++ LD VLIL + + + ++ E F Sbjct: 68 S-GHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTGFTEPEVLQIFCD 126 Query: 151 VLEAVRHCHNCG--VLHRDIKDENILIDLNRGELKLIDFGSGAL-----LKDTVYT---- 199 EAV H C ++HRD+K ENIL++ + G L DFGS KD V Sbjct: 127 TCEAVARLHQCKTPIIHRDLKVENILLN-DGGNYVLCDFGSATNKFLNPQKDGVNVVEEE 185 Query: 200 -DFDGTRVYSPPEWIR--YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDE-EIIRGQVFF 255 T Y PE I + A +W+LG LLY + +PF + I G Sbjct: 186 IKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGNFTI 245 Query: 256 RQ--RVSSECQHLIRWCLALRPSDRPTFEEIQNHPW-MQDVLLPQETA-EIHLHSLSPGP 311 R S LIR+ L P RP ++ + P + S P P Sbjct: 246 PDNSRYSRNIHCLIRFMLEPDPEHRPDIFQVSYFAFKFAAADCPVSNINNSSIPSALPEP 305 >4CRL-A nrPDB Length = 406 Score = 166 bits (422), Expect = 9e-42, Method: Composition-based stats. Identities = 71/352 (20%), Positives = 127/352 (36%), Gaps = 87/352 (24%) Query: 24 KLAPGKEKEPLESQYQV-GPLLGSGGFGSVYSGIRVSDNLP--VAIKHVEKDRISDWGEL 80 K+ E+E +E ++ G +G G +G VY R A+K +E IS Sbjct: 9 KVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS----- 63 Query: 81 PNGTRVPMEVVLLKKVSSGFSGVIRLLDWF--ERPDSFVLILERPEPVQDLFDFITERGA 138 E+ LL+++ VI L F L+ + E DL+ I A Sbjct: 64 ---MSACREIALLRELKH--PNVISLQKVFLSHADRKVWLLFDYAEH--DLWHIIKFHRA 116 Query: 139 ---------LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILI---DLNRGELKLID 186 L + +S +Q+L+ + + H VLHRD+K NIL+ RG +K+ D Sbjct: 117 SKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIAD 176 Query: 187 FGSGALLKDTV-----YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI- 240 G L + T Y PE + R++ ++ +W++G + +++ + Sbjct: 177 MGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPI 236 Query: 241 ------------PFEHDE-----------------EIIRG-------------------- 251 P+ HD+ +I + Sbjct: 237 FHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSL 296 Query: 252 -QVFFRQRVSSECQ--HLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA 300 + + +V + + HL++ L + P R T E+ P+ + LP Sbjct: 297 IKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDV 348 >4G3E-A nrPDB Length = 352 Score = 166 bits (421), Expect = 1e-41, Method: Composition-based stats. Identities = 58/303 (19%), Positives = 106/303 (34%), Gaps = 44/303 (14%) Query: 10 AHLRAAPCNDLHATKLAPGKEKEPLESQYQ-------VGPLLGSGGFGSVYSGIRVSDNL 62 A L+ + ++ +P++ +Y+ P +G G FG V+ Sbjct: 41 AKLQRLGPETEDNEGVLLTEKLKPVDYEYREEVHWMTHQPRVGRGSFGEVHRMKDKQTGF 100 Query: 63 PVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILER 122 A+K V + E+V +SS ++ L + +E Sbjct: 101 QCAVKKVRLEVFRVE-----------ELVACAGLSS--PRIVPLYGAVREGPWVNIFMEL 147 Query: 123 PEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL 182 E L I + G L E+ A + Q LE + + H +LH D+K +N+L+ + Sbjct: 148 LEG-GSLGQLIKQMGCLPEDRALYYLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRA 206 Query: 183 KLIDFGSGALLK-DTVYTDFD------GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDM 235 L DFG L+ D + GT + PE + + +WS ++ M Sbjct: 207 ALCDFGHALCLQPDGLGKSLLTGDYIPGTETHMAPEVVMGKPCDAK-VDIWSSCCMMLHM 265 Query: 236 VCGDIPFEHDEEIIRGQVFFR------------QRVSSECQHLIRWCLALRPSDRPTFEE 283 + G P+ + RG + + + I+ L P R + E Sbjct: 266 LNGCHPW---TQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKEPVHRASAME 322 Query: 284 IQN 286 ++ Sbjct: 323 LRR 325 >2PMN-X nrPDB Length = 348 Score = 166 bits (420), Expect = 1e-41, Method: Composition-based stats. Identities = 68/313 (21%), Positives = 112/313 (35%), Gaps = 53/313 (16%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 KEK+ + Y++ L G F + DN A+K EK + + + Sbjct: 24 KEKDKYINDYRIIRTLNQGKFNKIILCE--KDNKFYALKKYEKSLLEKKRDFTKSNNDKI 81 Query: 89 EVVLLKKVSSGFSGVIRLL------------DWFERPDSFVLILERPEPVQDL-----FD 131 + K F ++++ D +I E E L F Sbjct: 82 SI---KSKYDDFKNELQIITDIKNEYCLTCEGIITNYDEVYIIYEYMENDSILKFDEYFF 138 Query: 132 FITER--GALQEELARSFFWQVLEAVRHCH-NCGVLHRDIKDENILIDLNRGELKLIDFG 188 + + + ++ + VL + + H + HRD+K NIL+D N G +KL DFG Sbjct: 139 VLDKNYTCFIPIQVIKCIIKSVLNSFSYIHNEKNICHRDVKPSNILMDKN-GRVKLSDFG 197 Query: 189 SGALLKDTVYTDFDGTRVYSPPEWIRYHR-YHGRSAAVWSLGILLYDMVCGDIPFEHDEE 247 + D GT + PPE+ Y+G +WSLGI LY M +PF Sbjct: 198 ESEYMVDKKIKGSRGTYEFMPPEFFSNESSYNGAKVDIWSLGICLYVMFYNVVPFSLKIS 257 Query: 248 II----------------RGQVFFR----------QRVSSECQHLIRWCLALRPSDRPTF 281 ++ R + +S+E ++ L P++R T Sbjct: 258 LVELFNNIRTKNIEYPLDRNHFLYPLTNKKSTCSNNFLSNEDIDFLKLFLRKNPAERITS 317 Query: 282 EEIQNHPWMQDVL 294 E+ H W+ D Sbjct: 318 EDALKHEWLADTN 330 >4FL3-A nrPDB Length = 635 Score = 165 bits (418), Expect = 2e-41, Method: Composition-based stats. Identities = 50/254 (19%), Positives = 106/254 (41%), Gaps = 21/254 (8%) Query: 42 PLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS 101 LGSG FG+V G + K ++ + + E +++++ + + Sbjct: 375 KELGSGNFGTVKKGYYQMKKVVKT--VAVKILKNEANDPALKDELLAEANVMQQLDNPY- 431 Query: 102 GVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNC 161 ++R++ E +S++L++E E + L ++ + ++++ QV +++ Sbjct: 432 -IVRMIGICE-AESWMLVMEMAE-LGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 488 Query: 162 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV-----YSPPEWIRYH 216 +HRD+ N+L+ + + K+ DFG L+ T + PE I Y+ Sbjct: 489 NFVHRDLAARNVLL-VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 547 Query: 217 RYHGRSAAVWSLGILLYDMVC-GDIPF------EHDEEIIRGQVF-FRQRVSSECQHLIR 268 ++ +S VWS G+L+++ G P+ E + +G+ E L+ Sbjct: 548 KFSSKS-DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMN 606 Query: 269 WCLALRPSDRPTFE 282 C +RP F Sbjct: 607 LCWTYDVENRPGFA 620 >2H34-A nrPDB Length = 309 Score = 164 bits (415), Expect = 6e-41, Method: Composition-based stats. Identities = 62/253 (24%), Positives = 100/253 (39%), Gaps = 20/253 (7%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 Y++ L+G GG G VY VA+K + + SD TR+ E ++ Sbjct: 36 YRLRRLVGRGGMGDVYEAEDTVRERIVALKLMSETLSSDP---VFRTRMQREARTAGRLQ 92 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRH 157 V+ + D+ E + + V DL + +G L A + Q+ A+ Sbjct: 93 E--PHVVPIHDFGEIDGQLYVDMRLINGV-DLAAMLRRQGPLAPPRAVAIVRQIGSALDA 149 Query: 158 CHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDF---DGTRVYSPPEWIR 214 H G HRD+K ENIL+ + L+DFG + D T GT Y PE Sbjct: 150 AHAAGATHRDVKPENILVSADDF-AYLVDFGIASATTDEKLTQLGNTVGTLYYMAPERFS 208 Query: 215 YHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRG---------QVFFRQRVSSECQH 265 + A +++L +LY+ + G P++ D+ + G R + Sbjct: 209 -ESHATYRADIYALTCVLYECLTGSPPYQGDQLSVMGAHINQAIPRPSTVRPGIPVAFDA 267 Query: 266 LIRWCLALRPSDR 278 +I +A P DR Sbjct: 268 VIARGMAKNPEDR 280 >5WNL-A nrPDB Length = 342 Score = 164 bits (415), Expect = 6e-41, Method: Composition-based stats. Identities = 62/265 (23%), Positives = 101/265 (38%), Gaps = 33/265 (12%) Query: 42 PLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS 101 +GSGGFG VY V +AIK S + + R+ + K + F Sbjct: 26 EKVGSGGFGQVYKVRHVHWKTWLAIKC------SPSLHVDDRERMELLEEAKKMEMAKFR 79 Query: 102 GVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH-- 159 ++ + + P L++E E L + L +L + + H Sbjct: 80 YILPVYGICQEP--VGLVMEYMET-GSLEKLLASE-PLPWDLRFRIVHETAVGMNFLHCM 135 Query: 160 NCGVLHRDIKDENILIDLNRGELKLIDFGSGA-----LLKDTVYTDFDGTRVYSPPEWIR 214 + +LH ++K NIL+D + +K+ DFG D GT Y PPE IR Sbjct: 136 SPPLLHLNLKPANILLDAHY-HVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIR 194 Query: 215 YH-RYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVF--------------FRQRV 259 R V+S I+++ ++ PF ++ I+ + R R Sbjct: 195 EKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKGHRPELPPICRPRPRA 254 Query: 260 SSECQHLIRWCLALRPSDRPTFEEI 284 + L++ C P RPTF+EI Sbjct: 255 CASLIGLMQRCWHADPQVRPTFQEI 279 >3UIU-A nrPDB Length = 306 Score = 163 bits (413), Expect = 8e-41, Method: Composition-based stats. Identities = 64/284 (22%), Positives = 113/284 (39%), Gaps = 49/284 (17%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 ++ L+GSGGFG V+ D I+ V+ N + EV L K+ Sbjct: 13 DFKEIELIGSGGFGQVFKAKHRIDGKTYVIRRVK----------YNNEKAEREVKALAKL 62 Query: 97 SSGFSGVIRLLDWFERPDS-----------------------------FVLILERPEPVQ 127 ++ ++ D + +E + Sbjct: 63 DHV--NIVHYNGCWDGFDYDPETSDDSLESSDYDPENSKNSSRSKTKCLFIQMEFCDK-G 119 Query: 128 DLFDFITERGA--LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLI 185 L +I +R L + LA F Q+ + V + H+ ++HRD+K NI + ++ ++K+ Sbjct: 120 TLEQWIEKRRGEKLDKVLALELFEQITKGVDYIHSKKLIHRDLKPSNIFL-VDTKQVKIG 178 Query: 186 DFGSGALLK-DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMV-CGDIPFE 243 DFG LK D T GT Y PE I Y G+ +++LG++L +++ D FE Sbjct: 179 DFGLVTSLKNDGKRTRSKGTLRYMSPEQISSQDY-GKEVDLYALGLILAELLHVCDTAFE 237 Query: 244 HDEEIIRGQVFFRQRV-SSECQHLIRWCLALRPSDRPTFEEIQN 286 + + + + + L++ L+ +P DRP EI Sbjct: 238 TSKFFTDLRDGIISDIFDKKEKTLLQKLLSKKPEDRPNTSEILR 281 >4LFI-A nrPDB Length = 374 Score = 163 bits (413), Expect = 9e-41, Method: Composition-based stats. Identities = 61/339 (17%), Positives = 122/339 (35%), Gaps = 79/339 (23%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAI----------------------- 66 + Y++ +G G + V+ G+++ + + I Sbjct: 34 DWSTNTKDYEIENKVGRGKYSEVFQGVKLDSKVKIVIKMLKPVKKKKIKREIKILTDLSN 93 Query: 67 -KH----VEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFV--LI 119 K + + + + + + +G + +I L D + P S L+ Sbjct: 94 EKVPPTTLPFQKDQYYTNQKEDVLKFIRPYIFDQPHNGHANIIHLFDIIKDPISKTPALV 153 Query: 120 LERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNR 179 E + V DF L + R + +++L+A+ +CH+ G++HRD+K N++ID Sbjct: 154 FEYVDNV----DFRILYPKLTDLEIRFYMFELLKALDYCHSMGIMHRDVKPHNVMIDHKN 209 Query: 180 GELKLIDFGSGALLK-DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCG 238 +L+LID+G + Y +R + PE + +R + S +WS G +L M+ Sbjct: 210 KKLRLIDWGLAEFYHVNMEYNVRVASRFFKGPELLVDYRMYDYSLDLWSFGTMLASMIFK 269 Query: 239 DIPFEH--------------------DEEIIRGQVFFRQRV------------------- 259 PF H ++ +++ ++ + Sbjct: 270 REPFFHGTSNTDQLVKIVKVLGTSDFEKYLLKYEITLPREFYDMDQYIRKPWHRFINDGN 329 Query: 260 -----SSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 + E LI L +R T +E HPW + Sbjct: 330 KHLSGNDEIIDLIDNLLRYDHQERLTAKEAMGHPWFAPI 368 >5L2Q-C nrPDB Length = 320 Score = 162 bits (411), Expect = 2e-40, Method: Composition-based stats. Identities = 52/276 (18%), Positives = 98/276 (35%), Gaps = 43/276 (15%) Query: 53 YSGIRVSDNLPVAIKHVEKDRISDWGELPNGTR-----VPMEVVLLKKVSSGFSGVIRLL 107 + + +K + + D G R + E LL + GV+ Sbjct: 33 CLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLL-SLLHTQDGVVHHH 91 Query: 108 DWFER------------------PDSFVLILERPE---------PVQDLFDFITERGALQ 140 F+ L+L+ + +L ++ + L Sbjct: 92 GLFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLS 151 Query: 141 EELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVY 198 E F+ V+ V H ++HRD+K N++++ + + +F G L + + Sbjct: 152 ERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLL 211 Query: 199 TDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD------EEIIRGQ 252 D G+ Y P+ + Y G+ + +W+LG++L+ M+ G PF +I + Sbjct: 212 KDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAE 271 Query: 253 VFFRQ--RVSSECQHLIRWCLALRPSDRPTFEEIQN 286 + RVS LIR L L P R ++ Sbjct: 272 YTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLE 307 >2RIO-A nrPDB Length = 434 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 68/293 (23%), Positives = 111/293 (37%), Gaps = 58/293 (19%) Query: 42 PLLGSGGFGSV-YSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGF 100 +LG G G+V + G PVA+K + + D+ ++ ME+ LL + S Sbjct: 21 KILGYGSSGTVVFQGSFQ--GRPVAVKRM----LIDFCDI-----ALMEIKLLTE-SDDH 68 Query: 101 SGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELAR-------SFFWQVLE 153 VIR + LE +L D + + E L S Q+ Sbjct: 69 PNVIRYYCSETTDRFLYIALELCN--LNLQDLVESKNVSDENLKLQKEYNPISLLRQIAS 126 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRG------------ELKLIDFGSGALLKD------ 195 V H H+ ++HRD+K +NIL+ + + + DFG L Sbjct: 127 GVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFR 186 Query: 196 TVYTDFDGTRVYSPPEW------IRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEH---- 244 T + GT + PE ++ R RS ++S+G + Y ++ G PF Sbjct: 187 TNLNNPSGTSGWRAPELLEESNNLQTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSR 246 Query: 245 DEEIIRG-------QVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 + IIRG + + + +E LI + P RPT ++ HP Sbjct: 247 ESNIIRGIFSLDEMKCLHDRSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLF 299 >5C26-A nrPDB Length = 299 Score = 162 bits (410), Expect = 2e-40, Method: Composition-based stats. Identities = 50/254 (19%), Positives = 106/254 (41%), Gaps = 21/254 (8%) Query: 42 PLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS 101 LGSG FG+V G + K ++ + + E +++++ + + Sbjct: 33 KELGSGNFGTVKKGYYQMKKVVKT--VAVKILKNEANDPALKDELLAEANVMQQLDNPY- 89 Query: 102 GVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNC 161 ++R++ E +S++L++E E + L ++ + ++++ QV +++ Sbjct: 90 -IVRMIGICE-AESWMLVMEMAE-LGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEES 146 Query: 162 GVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV-----YSPPEWIRYH 216 +HRD+ N+L+ + + K+ DFG L+ T + PE I Y+ Sbjct: 147 NFVHRDLAARNVLL-VTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYY 205 Query: 217 RYHGRSAAVWSLGILLYDMVC-GDIPF------EHDEEIIRGQVF-FRQRVSSECQHLIR 268 ++ +S VWS G+L+++ G P+ E + +G+ E L+ Sbjct: 206 KFSSKS-DVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMN 264 Query: 269 WCLALRPSDRPTFE 282 C +RP F Sbjct: 265 LCWTYDVENRPGFA 278 >2Y4I-B nrPDB Length = 319 Score = 161 bits (408), Expect = 4e-40, Method: Composition-based stats. Identities = 55/281 (19%), Positives = 114/281 (40%), Gaps = 36/281 (12%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 +E + Q ++G L+G G FG VY G VAI+ ++ +R ++ Sbjct: 26 QEWDIPFEQLEIGELIGKGRFGQVYHGRWHG---EVAIRLIDIERDNEDQ----LKAFKR 78 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSF 147 EV+ ++ V+ + P +I + L+ + + L R Sbjct: 79 EVMAYRQTRH--ENVVLFMGACMSPPHLAIITSLCKGR-TLYSVVRDAKIVLDVNKTRQI 135 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALL-------KDTVYTD 200 ++++ + + H G+LH+D+K +N+ D G++ + DFG ++ ++ Sbjct: 136 AQEIVKGMGYLHAKGILHKDLKSKNVFYD--NGKVVITDFGLFSISGVLQAGRREDKLRI 193 Query: 201 FDGTRVYSPPEWIRYHRYHG--------RSAAVWSLGILLYDMVCGDIPF---EHDEEII 249 +G + PE IR + + V++LG + Y++ + PF + I Sbjct: 194 QNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIW 253 Query: 250 RGQVFFRQRVS-----SECQHLIRWCLALRPSDRPTFEEIQ 285 + + +S E ++ +C A +RPTF ++ Sbjct: 254 QMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLM 294 >5U6C-A nrPDB Length = 315 Score = 161 bits (407), Expect = 4e-40, Method: Composition-based stats. Identities = 56/271 (20%), Positives = 99/271 (36%), Gaps = 33/271 (12%) Query: 40 VGPLLGSGGFGSVYSGIRVS---DNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 +G +LG G FGSV G +L VA+K ++ D S E +K Sbjct: 40 LGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQRE----IEEFLSEAACMKDF 95 Query: 97 SSGFSGVIRLLDWFERPDS----FVLILERPEPVQDLFDFI------TERGALQEELARS 146 S V+RLL S +++ DL ++ T + + Sbjct: 96 SH--PNVMRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLK 153 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV 206 F + + + N LHRD+ N ++ + + + DFG + Y G Sbjct: 154 FMVDIALGMEYLSNRNFLHRDLAARNCML-RDDMTVCVADFGLSKKIYSGDYY-RQGRIA 211 Query: 207 YSPPEWIRYH----RYHGRSAAVWSLGILLYDMVC-GDIPFEHDEE------IIRGQVFF 255 P +WI R + + VW+ G+ ++++ G P+ + ++ G Sbjct: 212 KMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLK 271 Query: 256 -RQRVSSECQHLIRWCLALRPSDRPTFEEIQ 285 + E ++ C P DRPTF ++ Sbjct: 272 QPEDCLDELYEIMYSCWRTDPLDRPTFSVLR 302 >5HVK-A nrPDB Length = 315 Score = 159 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 51/282 (18%), Positives = 97/282 (34%), Gaps = 39/282 (13%) Query: 41 GPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGF 100 G +LG G FG + +K + + E T EV +++ + Sbjct: 19 GEVLGKGCFGQAIKVTHRETGEVMVMKEL-----IRFDEETQRT-FLKEVKVMRCLEH-- 70 Query: 101 SGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA-LQEELARSFFWQVLEAVRHCH 159 V++ + + I E + L I + SF + + + H Sbjct: 71 PNVLKFIGVLYKDKRLNFITEYIKG-GTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLH 129 Query: 160 NCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT----------------VYTDFDG 203 + ++HR++ N L+ N+ + + DFG L+ D G Sbjct: 130 SMNIIHRNLNSHNCLVRENKNVV-VADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVG 188 Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCG------DIPFEHDEEI-IRG--QVF 254 + PE I R + V+S GI+L +++ +P D + +RG + Sbjct: 189 NPYWMAPEMING-RSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRY 247 Query: 255 FRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLP 296 + C L P RP+F + H W++ + + Sbjct: 248 CPPNCPPSFFPITVRCCDLDPEKRPSFVK-LEH-WLETLRMH 287 >3LLT-A nrPDB Length = 360 Score = 159 bits (403), Expect = 1e-39, Method: Composition-based stats. Identities = 64/345 (18%), Positives = 113/345 (32%), Gaps = 92/345 (26%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 K+ L + + V +G G FG V + + A+K V + Sbjct: 27 WKKGMLLNNAFLVIRKMGDGTFGRVLLCQHIDNKKYYAVKVVRNIK-------KYTRSAK 79 Query: 88 MEVVLLKKVS---SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER--GALQEE 142 +E +LKK+ + +++ F D LI E P L++ IT E Sbjct: 80 IEADILKKIQNDDINNNNIVKYHGKFMYYDHMCLIFEPLGP--SLYEIITRNNYNGFHIE 137 Query: 143 LARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE--------------------- 181 + + ++L+A+ + + H D+K ENIL+D E Sbjct: 138 DIKLYCIEILKALNYLRKMSLTHTDLKPENILLDDPYFEKSLITVRRVTDGKKIQIYRTK 197 Query: 182 ---LKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCG 238 +KLIDFG K + TR Y PE I + S+ +WS G +L ++ G Sbjct: 198 STGIKLIDFGCATF-KSDYHGSIINTRQYRAPEVILNLGW-DVSSDMWSFGCVLAELYTG 255 Query: 239 DIPFEHDEEIIR----------------------------GQVFFRQRVSSECQHL---- 266 + F E + + + + Sbjct: 256 SLLFRTHEHMEHLAMMESIIQPIPKNMLYEATKTNGSKYVNKDELKLAWPENASSINSIK 315 Query: 267 -IRWC-------------------LALRPSDRPTFEEIQNHPWMQ 291 ++ C L + P+ RP+ E+ H +++ Sbjct: 316 HVKKCLPLYKIIKHELFCDFLYSILQIDPTLRPSPAELLKHKFLE 360 >3QD2-B nrPDB Length = 332 Score = 158 bits (401), Expect = 2e-39, Method: Composition-based stats. Identities = 62/341 (18%), Positives = 122/341 (35%), Gaps = 97/341 (28%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 + ++ +G GGFG V+ D+ AIK + +V EV L K Sbjct: 6 TDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRE-----LAREKVMREVKALAK 60 Query: 96 VSSGFSGVIRL---------------------------------------------LDWF 110 + G++R +D F Sbjct: 61 LEH--PGIVRYFNAWLETPPEKWQEEMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPF 118 Query: 111 ERPD------------SFVLILERPEPVQDLFDFITERGALQEEL---ARSFFWQVLEAV 155 + + ++ ++L D++ R +L++ F Q+ EAV Sbjct: 119 STKNTVGQLQPSSPKVYLYIQMQLCRK-ENLKDWMNRRCSLEDREHGVCLHIFIQIAEAV 177 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT--------------VYTDF 201 H+ G++HRD+K NI ++ +K+ DFG + +T Sbjct: 178 EFLHSKGLMHRDLKPSNIFFTMDD-VVKVGDFGLVTAMDQDEEEQTVLTPMPAYATHTGQ 236 Query: 202 DGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE---------HDEEIIRGQ 252 GT++Y PE I + Y ++SLG++L++++ F D ++ Sbjct: 237 VGTKLYMSPEQIHGNNY-SHKVDIFSLGLILFELLYS---FSTQMERVRIITDVRNLKFP 292 Query: 253 VFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDV 293 + F Q+ E +++ L+ P++RP +I + +++ Sbjct: 293 LLFTQKYPQE-HMMVQDMLSPSPTERPEATDIIENAIFENL 332 >3ZZW-A nrPDB Length = 289 Score = 157 bits (398), Expect = 4e-39, Method: Composition-based stats. Identities = 61/290 (21%), Positives = 107/290 (36%), Gaps = 43/290 (14%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIR-----VSDNLPVAIKHVEKDRISDWGELPN 82 GK KE S + LG FG VY G VAIK ++ D E P Sbjct: 1 GKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLK-----DKAEGPL 55 Query: 83 GTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA---- 138 E +L ++ V+ LL + +I DL +F+ R Sbjct: 56 REEFRHEAMLRARLQH--PNVVCLLGVVTKDQPLSMIFSYCS-HGDLHEFLVMRSPHSDV 112 Query: 139 ------------LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLID 186 L+ Q+ + + + V+H+D+ N+L+ ++ +K+ D Sbjct: 113 GSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLV-YDKLNVKISD 171 Query: 187 FGSGALLKDTVYTDFDGT----RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIP 241 G + Y G + PE I Y ++ S +WS G++L+++ G P Sbjct: 172 LGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDS-DIWSYGVVLWEVFSYGLQP 230 Query: 242 F--EHDEEII-----RGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEI 284 + +++++ R + + L+ C PS RP F++I Sbjct: 231 YCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDI 280 >5LPZ-A nrPDB Length = 332 Score = 157 bits (398), Expect = 5e-39, Method: Composition-based stats. Identities = 67/305 (21%), Positives = 111/305 (36%), Gaps = 52/305 (17%) Query: 15 APCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRI 74 P L L + L+GSGGFG VY I + D VAIK + Sbjct: 2 KPLRKLAFADLLQATNG------FHNDSLIGSGGFGDVYKAI-LKDGSAVAIKKLIHVSG 54 Query: 75 SDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT 134 E ++ ++ LL + + D +L+ E + L D + Sbjct: 55 QGDREFMAEMETIGKIK--------HRNLVPLLGYCKVGDERLLVYEFMK-YGSLEDVLH 105 Query: 135 ERGA----LQEELARSFFWQVLEAVRHCHNC---GVLHRDIKDENILIDLNRGELKLIDF 187 + L R + H+ ++HRD+K N+L+D N E ++ DF Sbjct: 106 DPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENL-EARVSDF 164 Query: 188 GSGALLK--DTVYT--DFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIP-- 241 G L+ DT + GT Y PPE+ + R + V+S G++L +++ G P Sbjct: 165 GMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKG-DVYSYGVVLLELLTGKRPTD 223 Query: 242 ---FEHDEEIIRGQVFFRQRVSSEC-QHLIR-----------------WCLALRPSDRPT 280 F + + + + R+S L++ CL R RPT Sbjct: 224 SPDFGDNNLVGWVKQHAKLRISDVFDPELMKEDPALEIELLQHLKVAVACLDDRAWRRPT 283 Query: 281 FEEIQ 285 ++ Sbjct: 284 MVQVM 288 >4TPT-A nrPDB Length = 303 Score = 157 bits (397), Expect = 7e-39, Method: Composition-based stats. Identities = 47/277 (16%), Positives = 94/277 (33%), Gaps = 46/277 (16%) Query: 41 GPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGF 100 G +LG G FG + + +K + + + EV +++ + Sbjct: 5 GEVLGKGFFGQAIKVTHKATGKVMVMKELIR------CDEETQKTFLTEVKVMRSLDH-- 56 Query: 101 SGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHN 160 V++ + + L+ E E L DF+ + F + + + H+ Sbjct: 57 PNVLKFIGVLYKDKKLNLLTEYIEG-GTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHS 115 Query: 161 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT----------------------VY 198 ++HRD+ N LI L++ + + DFG L+ + Sbjct: 116 MCIIHRDLNSHNCLIKLDKTVV-VADFGLSRLIVEERKRAPMEKATTKKRTLRKNDRKKR 174 Query: 199 TDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIR-------- 250 G + PE + Y + ++S GI+L +++ G + + + + R Sbjct: 175 YTVVGNPYWMAPEMLNGKSY-DETVDIFSFGIVLCEII-GQV-YADPDCLPRTLDFGLNV 231 Query: 251 ---GQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEI 284 + F L C L P RP F ++ Sbjct: 232 KLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKL 268 >5LPV-A nrPDB Length = 296 Score = 156 bits (396), Expect = 8e-39, Method: Composition-based stats. Identities = 67/305 (21%), Positives = 111/305 (36%), Gaps = 52/305 (17%) Query: 15 APCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRI 74 P L L + L+GSGGFG VY I + D VAIK + Sbjct: 2 KPLRKLAFADLLQATNG------FHNDSLIGSGGFGDVYKAI-LKDGSAVAIKKLIHVSG 54 Query: 75 SDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFIT 134 E ++ ++ LL + + D +L+ E + L D + Sbjct: 55 QGDREFMAEMETIGKIK--------HRNLVPLLGYCKVGDERLLVYEFMK-YGSLEDVLH 105 Query: 135 ERGA----LQEELARSFFWQVLEAVRHCHNC---GVLHRDIKDENILIDLNRGELKLIDF 187 + L R + H+ ++HRD+K N+L+D N E ++ DF Sbjct: 106 DPKKAGVKLNWSTRRKIAIGSARGLAFLHHNCSPHIIHRDMKSSNVLLDENL-EARVSDF 164 Query: 188 GSGALLK--DTVYT--DFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIP-- 241 G L+ DT + GT Y PPE+ + R + V+S G++L +++ G P Sbjct: 165 GMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSTKG-DVYSYGVVLLELLTGKRPTD 223 Query: 242 ---FEHDEEIIRGQVFFRQRVSSEC-QHLIR-----------------WCLALRPSDRPT 280 F + + + + R+S L++ CL R RPT Sbjct: 224 SPDFGDNNLVGWVKQHAKLRISDVFDPELMKEDPALEIELLQHLKVAVACLDDRAWRRPT 283 Query: 281 FEEIQ 285 ++ Sbjct: 284 MVQVM 288 >4PL5-B nrPDB Length = 435 Score = 155 bits (392), Expect = 2e-38, Method: Composition-based stats. Identities = 60/273 (21%), Positives = 106/273 (38%), Gaps = 37/273 (13%) Query: 41 GPLLGSGGFGS-VYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 99 +LG G G+ VY G+ DN VA+K + + S EV LL++ S Sbjct: 32 KDVLGHGAEGTIVYKGMF--DNRDVAVKRILPECFSFAD---------REVQLLRE-SDE 79 Query: 100 FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQE-ELARSFFWQVLEAVRHC 158 VIR + + +E L +++ ++ + Q + H Sbjct: 80 HPNVIRYFCTEKDRQFQYIAIELCAAT--LQEYVEQKDFAHLGLEPITLLHQTTSGLAHL 137 Query: 159 HNCGVLHRDIKDENILIDLN--RGELK--LIDFGSGALLK-----DTVYTDFDGTRVYSP 209 H+ ++HRD+K NIL+ + G +K + DFG L + + GT + Sbjct: 138 HSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIA 197 Query: 210 PEWIRYHRYH--GRSAAVWSLGILLYDMVC-GDIPF----EHDEEIIRGQVFFRQRVSSE 262 PE + + ++S G + Y ++ G PF + I+ G S + Sbjct: 198 PEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGYHPFGKSLQRQANILLGACNLDCFHSDK 257 Query: 263 -----CQHLIRWCLALRPSDRPTFEEIQNHPWM 290 + LI +A+ P RP+ + + HP+ Sbjct: 258 HEDVIARELIEKMIAMDPQQRPSAKHVLKHPFF 290 >5XD6-A nrPDB Length = 305 Score = 155 bits (391), Expect = 3e-38, Method: Composition-based stats. Identities = 56/239 (23%), Positives = 86/239 (35%), Gaps = 29/239 (12%) Query: 22 ATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELP 81 + P E + Y L+G G +G V+ GI S AIK ++ + D L Sbjct: 8 SVAAIPADELRDITDNYGSKSLIGEGSYGRVFYGILKS-GKAAAIKKLDSSKQPDQEFLA 66 Query: 82 NGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA--- 138 + V L++ V+ LL + VL E P L D + R Sbjct: 67 QVSMVSR----LRQ-----ENVVALLGYCVDGPLRVLAYEYA-PNGSLHDILHGRKGVKG 116 Query: 139 ------LQEELARSFFWQVLEAVRHCHNC---GVLHRDIKDENILIDLNRGELKLIDFGS 189 L + + H V+HRDIK N+L+ + K+ DF Sbjct: 117 AQPGPVLSWHQRVKIAVGAARGLEYLHEKANPHVIHRDIKSSNVLL-FDDDVAKIADFDL 175 Query: 190 GALLKDT----VYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH 244 D T GT Y PE+ +S V+S G++L +++ G P +H Sbjct: 176 SNQAPDMAARLHSTRVLGTFGYHAPEYAMTGTLSTKS-DVYSFGVVLLELLTGRKPVDH 233 >3UIM-A nrPDB Length = 326 Score = 154 bits (389), Expect = 5e-38, Method: Composition-based stats. Identities = 59/292 (20%), Positives = 115/292 (39%), Gaps = 44/292 (15%) Query: 29 KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPM 88 +E + + +LG GGFG VY G ++D VA+K ++++R + Sbjct: 23 RELQVASDNFSNKNILGRGGFGKVYKGR-LADGTLVAVKRLKEERTQGGE-----LQFQT 76 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPV---QDLFDFITERGALQEELAR 145 EV ++ ++RL + P +L+ L + + L + Sbjct: 77 EVEMISMAVHR--NLLRLRGFCMTPTERLLVYPYMANGSVASCLRERPESQPPLDWPKRQ 134 Query: 146 SFFWQVLEAVRHCHNC---GVLHRDIKDENILIDLNRGELKLIDFGSGALL--KDTVYTD 200 + + H+ ++HRD+K NIL+D + + DFG L+ KDT T Sbjct: 135 RIALGSARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAV-VGDFGLAKLMDYKDTHVTT 193 Query: 201 FD-GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE-----HDEEII----- 249 GT + PE++ + V+ G++L +++ G F+ +D++++ Sbjct: 194 AVRGTIGHIAPEYLSTGK-SSEKTDVFGYGVMLLELITGQRAFDLARLANDDDVMLLDWV 252 Query: 250 RGQVFFRQ------------RVSSECQHLIR---WCLALRPSDRPTFEEIQN 286 +G + ++ E + LI+ C P +RP E+ Sbjct: 253 KGLLKEKKLEALVDVDLQGNYKDEEVEQLIQVALLCTQSSPMERPKMSEVVR 304 >4F9B-A nrPDB Length = 361 Score = 153 bits (388), Expect = 7e-38, Method: Composition-based stats. Identities = 67/356 (18%), Positives = 116/356 (32%), Gaps = 107/356 (30%) Query: 34 LESQYQVGPLLGSGGFGSVYSG---IRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 L + +++ +G G F SVY ++V +A+KH+ + R+ E+ Sbjct: 19 LSNVFKIEDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPT--------SHPIRIAAEL 70 Query: 91 VLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQ 150 L V+ G V+ + F + D V+ + E + D + +L + R + Sbjct: 71 QCL-TVAGGQDNVMGVKYCFRKNDHVVIAMPYLE-HESFLDIL---NSLSFQEVREYMLN 125 Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDT-------------- 196 + +A++ H G++HRD+K N L + + L+DFG DT Sbjct: 126 LFKALKRIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTHDTKIELLKFVQSEAQQ 185 Query: 197 ----------------VYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI 240 GT + PE + + +WS G++ ++ G Sbjct: 186 ERCSQNKCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRY 245 Query: 241 PFE----------------HDEEIIRGQVFFRQR--VSSE--CQHLIRWC---------- 270 PF E I+ F + S E Q L + C Sbjct: 246 PFYKASDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPAQDLRKLCERLRGMDSST 305 Query: 271 ----------------LA---------------LRPSDRPTFEEIQNHPWMQDVLL 295 L P+ R T EE HP+ +D+ L Sbjct: 306 PKLTSDIQGHATNLEGWNEVPDEAYDLLDKLLDLNPASRITAEEALLHPFFKDMSL 361 >3SV0-A nrPDB Length = 483 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 62/288 (21%), Positives = 123/288 (42%), Gaps = 40/288 (13%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 +++++G +GSG FG +Y G + N VAIK ++ E + + Sbjct: 7 NKFRLGRKIGSGSFGEIYLGTNIQTNEEVAIKL--------ENVKTKHPQLLYESKIYRI 58 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITERGALQEELARSFFWQVLEA 154 + G G+ + + D VL+++ P ++DLF+F + + L + Q++ Sbjct: 59 LQGGT-GIPNVRWFGVEGDYNVLVMDLLGPSLEDLFNFCSRK--LSLKTVLMLADQMINR 115 Query: 155 VRHCHNCGVLHRDIKDENIL--IDLNRGELKLIDFGSGALLKDT---------VYTDFDG 203 V H+ LHRDIK +N L + ++ +IDFG +DT + G Sbjct: 116 VEFVHSKSFLHRDIKPDNFLMGLGRRANQVYIIDFGLAKKYRDTSTHQHIPYRENKNLTG 175 Query: 204 TRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR---QRVS 260 T Y+ R + SLG +L + G +P++ + + Q + + ++V+ Sbjct: 176 TARYASVNTHLGIE-QSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYEKISEKKVA 234 Query: 261 SECQHLIR-----------WCLALRPSDRPTFEEIQNHPWMQDVLLPQ 297 + + L R +C +LR D+P + ++ +D+ + + Sbjct: 235 TSIEALCRGYPTEFASYFHYCRSLRFDDKPDYSYLKR--LFRDLFIRE 280 >4EUU-A nrPDB Length = 319 Score = 153 bits (386), Expect = 1e-37, Method: Composition-based stats. Identities = 53/232 (22%), Positives = 88/232 (37%), Gaps = 24/232 (10%) Query: 40 VGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 99 + +LG G +V+ G AIK ++ E +LKK++ Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ-----MREFEVLKKLNH- 66 Query: 100 FSGVIRLLDWFERPD--SFVLILERPEPVQDLFDFITERG---ALQEELARSFFWQVLEA 154 +++L E VLI+E P L+ + E L E V+ Sbjct: 67 -KNIVKLFAIEEETTTRHKVLIMEFC-PCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 124 Query: 155 VRHCHNCGVLHRDIKDENILI---DLNRGELKLIDFGSGALLKDTV-YTDFDGTRVYSPP 210 + H G++HR+IK NI+ + + KL DFG+ L+D + GT Y P Sbjct: 125 MNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP 184 Query: 211 EWIRY-------HRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF 255 + + +G + +WS+G+ Y G +PF E R + Sbjct: 185 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM 236 >4JLC-A nrPDB Length = 657 Score = 152 bits (385), Expect = 1e-37, Method: Composition-based stats. Identities = 53/232 (22%), Positives = 88/232 (37%), Gaps = 24/232 (10%) Query: 40 VGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 99 + +LG G +V+ G A+K ++ E +LKK++ Sbjct: 12 LSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQ-----MREFEVLKKLNH- 65 Query: 100 FSGVIRLLDWFERPD--SFVLILERPEPVQDLFDFITERG---ALQEELARSFFWQVLEA 154 +++L E VLI+E P L+ + E L E V+ Sbjct: 66 -KNIVKLFAIEEETTTRHKVLIMEFC-PCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 123 Query: 155 VRHCHNCGVLHRDIKDENILI---DLNRGELKLIDFGSGALLKDTV-YTDFDGTRVYSPP 210 + H G++HRDIK NI+ + + KL DFG+ L+D + GT Y P Sbjct: 124 MNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP 183 Query: 211 EWIRY-------HRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF 255 + + +G + +WS+G+ Y G +PF E R + Sbjct: 184 DMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVM 235 >6HV0-A nrPDB Length = 416 Score = 151 bits (383), Expect = 3e-37, Method: Composition-based stats. Identities = 59/273 (21%), Positives = 104/273 (38%), Gaps = 37/273 (13%) Query: 41 GPLLGSGGFGS-VYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 99 +LG G G+ VY G+ DN VA+K + + S EV LL++ S Sbjct: 13 KDVLGHGAEGTIVYRGMF--DNRDVAVKRILPECFSFAD---------REVQLLRE-SDE 60 Query: 100 FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQE-ELARSFFWQVLEAVRHC 158 VIR + + +E L +++ ++ + Q + H Sbjct: 61 HPNVIRYFCTEKDRQFQYIAIELCAAT--LQEYVEQKDFAHLGLEPITLLQQTTSGLAHL 118 Query: 159 HNCGVLHRDIKDENILIDLNRGELK----LIDFGSGALLK-----DTVYTDFDGTRVYSP 209 H+ ++HRD+K NILI + K + DFG L + + GT + Sbjct: 119 HSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIA 178 Query: 210 PEWIRYHRY--HGRSAAVWSLGILLYDMVC-GDIPF----EHDEEIIRGQ-----VFFRQ 257 PE + + ++S G + Y ++ G PF + I+ G + + Sbjct: 179 PEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEK 238 Query: 258 RVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 + LI +A+ P RP+ + + HP+ Sbjct: 239 HEDVIARELIEKMIAMDPQKRPSAKHVLKHPFF 271 >4EUT-A nrPDB Length = 396 Score = 151 bits (382), Expect = 3e-37, Method: Composition-based stats. Identities = 53/232 (22%), Positives = 88/232 (37%), Gaps = 24/232 (10%) Query: 40 VGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 99 + +LG G +V+ G AIK ++ E +LKK++ Sbjct: 13 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ-----MREFEVLKKLNH- 66 Query: 100 FSGVIRLLDWFERPD--SFVLILERPEPVQDLFDFITERG---ALQEELARSFFWQVLEA 154 +++L E VLI+E P L+ + E L E V+ Sbjct: 67 -KNIVKLFAIEEETTTRHKVLIMEFC-PCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 124 Query: 155 VRHCHNCGVLHRDIKDENILI---DLNRGELKLIDFGSGALLKDTV-YTDFDGTRVYSPP 210 + H G++HR+IK NI+ + + KL DFG+ L+D + GT Y P Sbjct: 125 MNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP 184 Query: 211 EWIRY-------HRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF 255 + + +G + +WS+G+ Y G +PF E R + Sbjct: 185 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM 236 >5VC6-A nrPDB Length = 289 Score = 151 bits (381), Expect = 4e-37, Method: Composition-based stats. Identities = 60/287 (20%), Positives = 104/287 (36%), Gaps = 36/287 (12%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 G K +++ +GSG FGSV+ ++ D AIK +K E Sbjct: 3 GSMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDE----QNAL 58 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER----GALQEEL 143 EV + S V+R + D ++ E L D I+E +E Sbjct: 59 REVYAHAVLG-QHSHVVRYFSAWAEDDHMLIQNEYCNG-GSLADAISENYRIMSYFKEAE 116 Query: 144 ARSFFWQVLEAVRHCHNCGVLHRDIKDENILID------------------LNRGELKLI 185 + QV +R+ H+ ++H DIK NI I N+ K+ Sbjct: 117 LKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIG 176 Query: 186 DFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD 245 D G + + G + E ++ + H A +++L + + G P + Sbjct: 177 DLGHVTRISSPQVEE--GDSRFLANEVLQENYTHLPKADIFALALTV-VCAAGAEPLPRN 233 Query: 246 ----EEIIRGQV-FFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNH 287 EI +G++ Q +S E L++ + P RP+ + H Sbjct: 234 GDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKH 280 >2BUJ-A nrPDB Length = 317 Score = 150 bits (379), Expect = 8e-37, Method: Composition-based stats. Identities = 58/281 (20%), Positives = 103/281 (36%), Gaps = 38/281 (13%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 Y LG GGF V + D A+K + E + E + + Sbjct: 28 NKHYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRIL------CHEQQDREEAQREADMHR 81 Query: 95 KVSSGFSGVIRLLDWF------ERPDSFVLILERPEPVQDLFDFITERG-ALQEELARSF 147 + ++RL+ + + +L + + + + + ++G L E+ Sbjct: 82 LFNH--PNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWL 139 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL-----------LKDT 196 + + H G HRD+K NIL+ + G+ L+D GS L Sbjct: 140 LLGICRGLEAIHAKGYAHRDLKPTNILLG-DEGQPVLMDLGSMNQACIHVEGSRQALTLQ 198 Query: 197 VYTDFDGTRVYSPPEW--IRYHRYHGRSAAVWSLGILLYDMVCGDIP----FEHDEEI-- 248 + T Y PE ++ H VWSLG +LY M+ G+ P F+ + + Sbjct: 199 DWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVAL 258 Query: 249 -IRGQVFFRQ--RVSSECQHLIRWCLALRPSDRPTFEEIQN 286 ++ Q+ Q R SS L+ + + P RP + + Sbjct: 259 AVQNQLSIPQSPRHSSALWQLLNSMMTVDPHQRPHIPLLLS 299 >6O8B-A nrPDB Length = 665 Score = 149 bits (377), Expect = 1e-36, Method: Composition-based stats. Identities = 53/232 (22%), Positives = 89/232 (38%), Gaps = 24/232 (10%) Query: 40 VGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 99 + +LG G +V+ G AIK ++ E +LKK++ Sbjct: 19 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ-----MREFEVLKKLNH- 72 Query: 100 FSGVIRLLDWFERPD--SFVLILERPEPVQDLFDFITERG---ALQEELARSFFWQVLEA 154 +++L E VLI+E P L+ + E L E V+ Sbjct: 73 -KNIVKLFAIEEETTTRHKVLIMEFC-PCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 130 Query: 155 VRHCHNCGVLHRDIKDENILI---DLNRGELKLIDFGSGALLKDTV-YTDFDGTRVYSPP 210 + H G++HR+IK NI+ + + KL DFG+ L+D + + GT Y P Sbjct: 131 MNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVELYGTEEYLHP 190 Query: 211 EWIRY-------HRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF 255 + + +G + +WS+G+ Y G +PF E R + Sbjct: 191 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM 242 >4LQP-A nrPDB Length = 508 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 44/166 (26%), Positives = 72/166 (43%), Gaps = 7/166 (4%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 + ++G G FG V + A+K + K + +L + V E +L Sbjct: 102 EDFHTVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAH---VKAERDVLAG 158 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 S + V+ L F+ LI+E P DL + E++ R + + + A+ Sbjct: 159 SDSPW--VVSLYYSFQDAQYLYLIMEFL-PGGDLMTMLIRWQLFTEDVTRFYMAECILAI 215 Query: 156 RHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDF 201 H G +HR IK +NILID+ RG +KL DFG T +++ Sbjct: 216 ETIHKLGFIHRAIKPDNILIDI-RGHIKLSDFGLSTGFHKTHDSNY 260 Score = 93.4 bits (231), Expect = 1e-19, Method: Composition-based stats. Identities = 33/117 (28%), Positives = 49/117 (41%), Gaps = 16/117 (13%) Query: 191 ALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF--EHDEEI 248 + + GT Y PE Y Y G+ WSLG ++Y+ + G PF E +E Sbjct: 313 RKSRRLMAYSTVGTPDYIAPEIFLYQGY-GQECDWWSLGAIMYECLIGWPPFCSETPQET 371 Query: 249 IRGQVFFRQ--------RVSSECQHLIRWCLALRPSDRP----TFEEIQNHPWMQDV 293 R + F Q +S E + LIR L R +EI++HP+ + V Sbjct: 372 YRKIMNFEQTLQFPDDIHISYEAEDLIRRLLTH-ADQRLGRHGGADEIKSHPFFRGV 427 >6NT9-A nrPDB Length = 742 Score = 149 bits (376), Expect = 2e-36, Method: Composition-based stats. Identities = 53/232 (22%), Positives = 88/232 (37%), Gaps = 24/232 (10%) Query: 40 VGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 99 + +LG G +V+ G AIK ++ E +LKK++ Sbjct: 11 LSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQ-----MREFEVLKKLNH- 64 Query: 100 FSGVIRLLDWFERPD--SFVLILERPEPVQDLFDFITERG---ALQEELARSFFWQVLEA 154 +++L E VLI+E P L+ + E L E V+ Sbjct: 65 -KNIVKLFAIEEETTTRHKVLIMEFC-PCGSLYTVLEEPSNAYGLPESEFLIVLRDVVGG 122 Query: 155 VRHCHNCGVLHRDIKDENILI---DLNRGELKLIDFGSGALLKDTV-YTDFDGTRVYSPP 210 + H G++HR+IK NI+ + + KL DFG+ L+D + GT Y P Sbjct: 123 MNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHP 182 Query: 211 EWIRY-------HRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF 255 + + +G + +WS+G+ Y G +PF E R + Sbjct: 183 DMYERAVLRKDHQKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM 234 >4TN6-A nrPDB Length = 318 Score = 148 bits (373), Expect = 4e-36, Method: Composition-based stats. Identities = 62/290 (21%), Positives = 120/290 (41%), Gaps = 44/290 (15%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 ++Y++G +GSG FG +Y G ++ VAIK ++ +E + K Sbjct: 7 NRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKL--------ECVKTKHPQLHIESKIYKM 58 Query: 96 VSSGFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITERGALQEELARSFFWQVLEA 154 + G G+ + D V+++E P ++DLF+F + + +L+ L Q++ Sbjct: 59 MQGGV-GIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLL--LADQMISR 115 Query: 155 VRHCHNCGVLHRDIKDENIL--IDLNRGELKLIDFGSGALLKD---------TVYTDFDG 203 + + H+ +HRD+K +N L + + +IDFG +D + G Sbjct: 116 IEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTG 175 Query: 204 TRVYSPPEWIRYHRY--HGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR----- 256 T Y+ I H R + SLG +L G +P++ + + Q + R Sbjct: 176 TARYAS---INTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKK 232 Query: 257 ---------QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQ 297 + SE + +C +LR D+P + ++ +++ Q Sbjct: 233 MSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQ--LFRNLFHRQ 280 >3VHK-A nrPDB Length = 368 Score = 147 bits (372), Expect = 5e-36, Method: Composition-based stats. Identities = 50/191 (26%), Positives = 81/191 (42%), Gaps = 21/191 (10%) Query: 110 FERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIK 169 F S + E E +DL+ + L E + +QV + + + +HRD+ Sbjct: 174 FVEEKSLSDV-EEEEAPEDLY-----KDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLA 227 Query: 170 DENILIDLNRGELKLIDFGSGA-LLKDTVYTDFDGTRV---YSPPEWIRYHRYHGRSAAV 225 NIL+ + +K+ DFG + KD Y R+ + PE I + R + + V Sbjct: 228 ARNILLS-EKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETI-FDRVYTIQSDV 285 Query: 226 WSLGILLYDMVC-GDIPFEH---DEEIIR-----GQVFFRQRVSSECQHLIRWCLALRPS 276 WS G+LL+++ G P+ DEE R ++ + E + C PS Sbjct: 286 WSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHGEPS 345 Query: 277 DRPTFEEIQNH 287 RPTF E+ H Sbjct: 346 QRPTFSELVEH 356 Score = 71.8 bits (175), Expect = 3e-13, Method: Composition-based stats. Identities = 18/115 (15%), Positives = 42/115 (36%), Gaps = 11/115 (9%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSG-----IRVSDNLPVAIKHVEKDRISDWGELPN 82 + E + ++G LG G FG V + + VA+K +++ Sbjct: 21 ASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSE----- 75 Query: 83 GTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG 137 + E+ +L + V+ LL +P ++++ +L ++ + Sbjct: 76 HRALMSELKILIHIGH-HLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKR 129 >3HNG-A nrPDB Length = 360 Score = 146 bits (368), Expect = 1e-35, Method: Composition-based stats. Identities = 45/190 (23%), Positives = 78/190 (41%), Gaps = 21/190 (11%) Query: 110 FERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIK 169 F+ S + E + + + E S+ +QV + + +HRD+ Sbjct: 173 FQEDKSLSDVEEEEDSDG------FYKEPITMEDLISYSFQVARGMEFLSSRKCIHRDLA 226 Query: 170 DENILIDLNRGELKLIDFGSGA-LLKDTVYTDFDGTRV---YSPPEWIRYHRYHGRSAAV 225 NIL+ N +K+ DFG + K+ Y TR+ + PE I + + + + V Sbjct: 227 ARNILLSEN-NVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESI-FDKIYSTKSDV 284 Query: 226 WSLGILLYDMVC-GDIPFEH---DEEII-RGQVFFRQRVS----SECQHLIRWCLALRPS 276 WS G+LL+++ G P+ DE+ R + R R E ++ C P Sbjct: 285 WSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRDPK 344 Query: 277 DRPTFEEIQN 286 +RP F E+ Sbjct: 345 ERPRFAELVE 354 Score = 72.2 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 18/117 (15%), Positives = 44/117 (37%), Gaps = 11/117 (9%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSG-----IRVSDNLPVAIKHVEKDRISDWGELPN 82 + E + ++G LG G FG V + VA+K +++ + + Sbjct: 19 ASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKA-- 76 Query: 83 GTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGAL 139 + E+ +L + V+ LL + ++++ +L +++ + L Sbjct: 77 ---LMTELKILTHIGH-HLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDL 129 >4M66-A nrPDB Length = 325 Score = 146 bits (368), Expect = 1e-35, Method: Composition-based stats. Identities = 72/299 (24%), Positives = 118/299 (39%), Gaps = 51/299 (17%) Query: 20 LHATKLAP-GKEKEPLESQYQVGPL--LGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISD 76 + + KL P G PL S+ ++ L +G GGFG V+ + N VA+K V +IS Sbjct: 1 MSSVKLWPTGASAVPLVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKIS- 59 Query: 77 WGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPD-SFV----LILERPEPVQDLFD 131 EV + + + V+ LL E FV L+ E L Sbjct: 60 -----------WEVKAMVNLRN--ENVLLLLGVTEDLQWDFVSGQALVTRFMEN-GSLAG 105 Query: 132 FITERGALQEELARSFFWQVLEAVRHCHN--CGVLHRDIKDENILIDLNRGELKLIDFGS 189 + L +V+ + + H+ +LHRD+K NIL+D KL DFG Sbjct: 106 LLQPEAPRPWPLLCRLLQEVVLGMCYLHSLDPPLLHRDLKPSNILLDPEL-HAKLADFGL 164 Query: 190 GAL--------LKDTVYTDFDGTRVYSPPEWI-RYHRYHGRSAAVWSLGILLYDMVCGDI 240 + D GT Y PE + + + +++ V+S GIL++ ++ G Sbjct: 165 STFQGGSQSGSGSGSGSRDSGGTLAYLDPELLFKVNLKASKASDVYSFGILVWAVLAGRE 224 Query: 241 PFEHDE-EIIRGQVFFRQRVSS---------------ECQHLIRWCLALRPSDRPTFEE 283 D+ +IR V RQ + + L+ C + +RP+F++ Sbjct: 225 AELVDKTSLIRETVCDRQSRPPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQD 283 >4WUA-A nrPDB Length = 401 Score = 145 bits (367), Expect = 2e-35, Method: Composition-based stats. Identities = 70/376 (18%), Positives = 114/376 (30%), Gaps = 124/376 (32%) Query: 31 KEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEV 90 + +Y V LG G F +V+ + VA+K V+ L E+ Sbjct: 36 GDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALD-------EI 88 Query: 91 VLLKKVSSGFSG------VIRLLDWFE----RPDSFVLILERPEPVQDLFDFITER-GAL 139 LLK V + V++LLD F+ ++ E L I L Sbjct: 89 RLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFE-VLGHHLLKWIIKSNYQGL 147 Query: 140 QEELARSFFWQVLEAVRHCH-NCGVLHRDIKDENILIDLNRG------------------ 180 + QVL+ + + H C ++H DIK ENIL+ +N Sbjct: 148 PLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAP 207 Query: 181 ------------------------------ELKLIDFGSGALLKDTVYTDFDGTRVYSPP 210 ++K+ D G+ + +T+ TR Y Sbjct: 208 PPSGSAVSTAPATAGNFLVNPLEPKNAEKLKVKIADLGNACWVH-KHFTEDIQTRQYRSL 266 Query: 211 EWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE------------------------HDE 246 E + Y+ + +WS + +++ GD FE + Sbjct: 267 EVLIGSGYNTPA-DIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRK 325 Query: 247 EIIRGQV---FFRQR-----------------------VSSE----CQHLIRWCLALRPS 276 I+ G+ FF ++ S E + L L P Sbjct: 326 LIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPE 385 Query: 277 DRPTFEEIQNHPWMQD 292 R T E HPW+ Sbjct: 386 KRATAAECLRHPWLNS 401 >5VDK-A nrPDB Length = 297 Score = 144 bits (363), Expect = 5e-35, Method: Composition-based stats. Identities = 53/286 (18%), Positives = 95/286 (33%), Gaps = 40/286 (13%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVV 91 E ++ +G G FG+VY I+ D AIK + + EL N EV Sbjct: 11 SRYEKEFLEVEKIGVGEFGTVYKCIKRLDGCVYAIKR----SMKTFTELSNENSALHEVY 66 Query: 92 LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER----GALQEELARSF 147 + V+R + D ++ E L I+E +E + Sbjct: 67 AHAVLGH-HPHVVRYYSSWAEDDHMIIQNEYCNG-GSLQAAISENTKSGNHFEEPKLKDI 124 Query: 148 FWQVLEAVRHCHNCGVLHRDIKDENILI-----DLNRGEL-----------------KLI 185 Q+ + + HN ++H DIK NI I + G + K+ Sbjct: 125 LLQISLGLNYIHNSSMVHLDIKPSNIFICHKMQSESSGVIEEVENEADWFLSANVMYKIG 184 Query: 186 DFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD 245 D G + +G + E ++ H A +++LG+ + + G + Sbjct: 185 DLGHATSINKP--KVEEGDSRFLANEILQEDYRHLPKADIFALGLTIA-VAAGAESLPTN 241 Query: 246 ----EEIIRGQV-FFRQRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 I +G Q +S L++ + RP+ + Sbjct: 242 GAAWHHIRKGNFPDVPQELSESFSSLLKNMIQPDAEQRPSAAALAR 287 >5FQD-C nrPDB Length = 341 Score = 144 bits (363), Expect = 5e-35, Method: Composition-based stats. Identities = 59/286 (20%), Positives = 114/286 (39%), Gaps = 39/286 (13%) Query: 28 GKEKEPLES-QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRV 86 G + E + +Y++ +GSG FG +Y I +++ VA+K + ++ Sbjct: 10 GSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKL--------ESQKARHPQL 61 Query: 87 PMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITERGALQEELAR 145 E L K + G G+ + + + D VL+++ P ++DLF+F + R + Sbjct: 62 LYESKLYKILQGGV-GIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRR--FTMKTVL 118 Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELK--LIDFGSGALLKDTVY----- 198 Q++ + + H +HRDIK +N L+ + R K LIDFG +D Sbjct: 119 MLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIP 178 Query: 199 ----TDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVF 254 + GT Y+ R + SLG +L +P++ + + Q + Sbjct: 179 YREDKNLTGTARYASINAHLGIE-QSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKY 237 Query: 255 FR--------------QRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 + + +E + +C LR + P + ++ Sbjct: 238 EKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQ 283 >2X7G-A nrPDB Length = 389 Score = 143 bits (360), Expect = 1e-34, Method: Composition-based stats. Identities = 65/378 (17%), Positives = 112/378 (29%), Gaps = 122/378 (32%) Query: 27 PGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRV 86 P K + +Y V LG G F +V+ + VA+K V+ + L Sbjct: 22 PVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALD----- 76 Query: 87 PMEVVLLKKVSSGFSG------VIRLLDWF----ERPDSFVLILERPEPVQDLFDFITER 136 E+ LLK V V++L+D F ++ E L I Sbjct: 77 --EIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFE-VLGHHLLKWIIKSN 133 Query: 137 -GALQEELARSFFWQVLEAVRHCHNC-GVLHRDIKDENILI------------------- 175 L +S QVL+ + + H+ ++H DIK ENIL+ Sbjct: 134 YQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQK 193 Query: 176 ---------------------------DLNRGELKLIDFGSGALLKDTVYTDFDGTRVYS 208 + ++ +K+ D G+ + +T+ TR Y Sbjct: 194 AGAPPPSGSAVSTAPAADLLVNPLDPRNADKIRVKIADLGNACWVH-KHFTEDIQTRQYR 252 Query: 209 PPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFE------------HDEEIIR------ 250 E + Y + +WS + +++ GD FE H II Sbjct: 253 SIEVLIGAGYSTPA-DIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIP 311 Query: 251 ------------------------------------GQVFFRQRVSSECQHLIRWCLALR 274 + + +++ + L + Sbjct: 312 RHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMV 371 Query: 275 PSDRPTFEEIQNHPWMQD 292 P R + E HPW+ Sbjct: 372 PEKRASAGECLRHPWLNS 389 >3Q4U-A nrPDB Length = 301 Score = 142 bits (359), Expect = 2e-34, Method: Composition-based stats. Identities = 53/301 (17%), Positives = 92/301 (30%), Gaps = 65/301 (21%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 + +G G +G V+ G VA+K + E L V Sbjct: 9 DITLLECVGKGRYGEVWRGSWQ--GENVAVKIFSSR---------DEKSWFRETELYNTV 57 Query: 97 SSGFSGVIRLLDWFERPDS----FVLILERPEPVQDLFDFITERGALQEELARSFFWQVL 152 ++ + LI E + L+D++ L + Sbjct: 58 MLRHENILGFIASDMTSRHSSTQLWLITHYHE-MGSLYDYLQLT-TLDTVSCLRIVLSIA 115 Query: 153 EAVRHCH--------NCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK------DTVY 198 + H H + HRD+K +NIL+ N G+ + D G + D Sbjct: 116 SGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKN-GQCCIADLGLAVMHSQSTNQLDVGN 174 Query: 199 TDFDGTRVYSPPEW----IRYHRYHG-RSAAVWSLGILLYDMVCG----------DIPFE 243 GT+ Y PE I+ + + +W+ G++L+++ PF Sbjct: 175 NPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFY 234 Query: 244 H------DEEIIRGQVFF---RQRVS---------SECQHLIRWCLALRPSDRPTFEEIQ 285 E +R V R + + L++ C PS R T I+ Sbjct: 235 DVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIK 294 Query: 286 N 286 Sbjct: 295 K 295 >4BTK-A nrPDB Length = 337 Score = 140 bits (353), Expect = 7e-34, Method: Composition-based stats. Identities = 57/272 (20%), Positives = 104/272 (38%), Gaps = 29/272 (10%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 ++ +++V +G GGFG +Y + + VA+K + MEV +L Sbjct: 54 VKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV--------ESAQQPKQVLKMEVAVL 105 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 KK+ G V R + ++++ RG Q+LE Sbjct: 106 KKLQ-GKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILE 164 Query: 154 AVRHCHNCGVLHRDIKDENILID---LNRGELKLIDFGSGALLKDTV--------YTDFD 202 ++ H+ G LHRDIK N + + ++DFG +T F Sbjct: 165 SIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFR 224 Query: 203 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE-----IIRGQVFFR- 256 GT Y+ +R GR +WSL +L + G +P+ ++ +I+ + R Sbjct: 225 GTVRYASVNA-HKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRM 283 Query: 257 --QRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 + + SE + +L +P ++ I + Sbjct: 284 LLKHMPSEFHLFLDHIASLDYFTKPDYQLIMS 315 >5AR8-A nrPDB Length = 326 Score = 140 bits (352), Expect = 1e-33, Method: Composition-based stats. Identities = 57/274 (20%), Positives = 101/274 (36%), Gaps = 36/274 (13%) Query: 41 GPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGF 100 L G G+V S + VA+KH+ I V E +L K + F Sbjct: 37 LRYLSRGASGTVSSARHADWRVQVAVKHL---HIHTPLLDSERKDVLREAEILHK--ARF 91 Query: 101 SGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQE---ELARSFFWQVLEAVRH 157 S ++ +L P+ ++ E P L + + + + L ++ V + Sbjct: 92 SYILPILGICNEPEFLGIVTEYM-PNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNY 150 Query: 158 CHNC--GVLHRDIKDENILIDLNRGELKLIDFGSGA-------LLKDTVYTDFDGTRVYS 208 HN +LH D+K +NIL+D N +K+ DFG + + GT +Y Sbjct: 151 LHNMTPPLLHHDLKTQNILLD-NEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYM 209 Query: 209 PPEWIRYHRYH--GRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF----RQRVSSE 262 PPE + ++S ++ ++++ PFE ++ R ++ E Sbjct: 210 PPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEE 269 Query: 263 -----------CQHLIRWCLALRPSDRPTFEEIQ 285 LI A P +RP+F + Sbjct: 270 SLPYDIPHRARMISLIESGWAQNPDERPSFLKCL 303 >4NFN-A nrPDB Length = 309 Score = 139 bits (350), Expect = 2e-33, Method: Composition-based stats. Identities = 57/272 (20%), Positives = 104/272 (38%), Gaps = 29/272 (10%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 ++ +++V +G GGFG +Y + + VA+K + MEV +L Sbjct: 19 VKDRWKVLKKIGGGGFGEIYEAMDLLTRENVALKV--------ESAQQPKQVLKMEVAVL 70 Query: 94 KKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLE 153 KK+ G V R + ++++ RG Q+LE Sbjct: 71 KKLQ-GKDHVCRFIGCGRNEKFNYVVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILE 129 Query: 154 AVRHCHNCGVLHRDIKDENILID---LNRGELKLIDFGSGALLKDTV--------YTDFD 202 ++ H+ G LHRDIK N + + ++DFG +T F Sbjct: 130 SIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRPPRNVAGFR 189 Query: 203 GTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEE-----IIRGQVFFR- 256 GT Y+ +R GR +WSL +L + G +P+ ++ +I+ + R Sbjct: 190 GTVRYASVNA-HKNREMGRHDDLWSLFYMLVEFAVGQLPWRKIKDKEQVGMIKEKYEHRM 248 Query: 257 --QRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 + + SE + +L +P ++ I + Sbjct: 249 LLKHMPSEFHLFLDHIASLDYFTKPDYQLIMS 280 >4M69-B nrPDB Length = 283 Score = 138 bits (349), Expect = 2e-33, Method: Composition-based stats. Identities = 53/256 (20%), Positives = 95/256 (37%), Gaps = 27/256 (10%) Query: 50 GSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDW 109 ++Y G PV IK + G + E+ +KK S ++R+ Sbjct: 23 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFT--FNDEIKTMKKFDS--PNILRIFGI 76 Query: 110 FER----PDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLH 165 P F +++E E + L + + L + + + H+ LH Sbjct: 77 CIDQTVKPPEFSIVMEYCE-LGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLH 135 Query: 166 RDIKDENILIDLNRGELKLIDFGSGA------LLKDTVYTDFDGTRVYSPPEWIRY-HRY 218 R+I + L+ ++KL F + + + +Y PE ++ Sbjct: 136 RNISSSSFLVAGGY-QVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCL 194 Query: 219 HGRSAAVWSLGILLYDMVCGDIPFEH-DEEIIR-------GQVFFRQRVSSECQHLIRWC 270 + A ++S GI+L+++ G IPFE D + IR Q Q + +I C Sbjct: 195 YDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINEC 254 Query: 271 LALRPSDRPTFEEIQN 286 A PS RP+ + I Sbjct: 255 RAHEPSQRPSVDGILE 270 >3MY0-A nrPDB Length = 305 Score = 138 bits (349), Expect = 2e-33, Method: Composition-based stats. Identities = 55/298 (18%), Positives = 92/298 (30%), Gaps = 65/298 (21%) Query: 40 VGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 99 + +G G +G V+ G+ VA+K + E + V Sbjct: 12 LVECVGKGRYGEVWRGLWH--GESVAVKIFSSR---------DEQSWFRETEIYNTVLLR 60 Query: 100 FSGVIRLLDWFERP----DSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 ++ + LI E L+DF+ +R L+ LA + Sbjct: 61 HDNILGFIASDMTSRNSSTQLWLITHYHE-HGSLYDFL-QRQTLEPHLALRLAVSAACGL 118 Query: 156 RHCH--------NCGVLHRDIKDENILIDLNRGELKLIDFGSGAL------LKDTVYTDF 201 H H + HRD K N+L+ N + + D G + D Sbjct: 119 AHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNL-QCCIADLGLAVMHSQGSDYLDIGNNPR 177 Query: 202 DGTRVYSPPEW----IRYHRYHGRS-AAVWSLGILLYDMVCG----------DIPFEH-- 244 GT+ Y PE IR + +W+ G++L+++ PF Sbjct: 178 VGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVEDYRPPFYDVV 237 Query: 245 ----DEEIIRGQVFFRQRVS------------SECQHLIRWCLALRPSDRPTFEEIQN 286 E ++ V Q+ S ++R C PS R T I+ Sbjct: 238 PNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKK 295 >4BTF-A nrPDB Length = 469 Score = 138 bits (349), Expect = 3e-33, Method: Composition-based stats. Identities = 53/256 (20%), Positives = 95/256 (37%), Gaps = 27/256 (10%) Query: 50 GSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDW 109 ++Y G PV IK + G + E+ +KK S ++R+ Sbjct: 209 STIYRGEYHRS--PVTIKVFNNPQAESVGIVRFT--FNDEIKTMKKFDS--PNILRIFGI 262 Query: 110 FER----PDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLH 165 P F +++E E + L + + L + + + H+ LH Sbjct: 263 CIDQTVKPPEFSIVMEYCE-LGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSETLH 321 Query: 166 RDIKDENILIDLNRGELKLIDFGSGA------LLKDTVYTDFDGTRVYSPPEWIRY-HRY 218 R+I + L+ ++KL F + + + +Y PE ++ Sbjct: 322 RNISSSSFLVAGGY-QVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCL 380 Query: 219 HGRSAAVWSLGILLYDMVCGDIPFEH-DEEIIR-------GQVFFRQRVSSECQHLIRWC 270 + A ++S GI+L+++ G IPFE D + IR Q Q + +I C Sbjct: 381 YDIKAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINEC 440 Query: 271 LALRPSDRPTFEEIQN 286 A PS RP+ + I Sbjct: 441 RAHEPSQRPSVDGILE 456 >2QKW-B nrPDB Length = 321 Score = 138 bits (348), Expect = 3e-33, Method: Composition-based stats. Identities = 48/219 (21%), Positives = 86/219 (39%), Gaps = 20/219 (9%) Query: 27 PGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRV 86 P + E + + L+G G FG VY G+ + D VA+K + E Sbjct: 30 PLVDLEEATNNFDHKFLIGHGVFGKVYKGV-LRDGAKVALKRRTPESSQGIEEFETEIET 88 Query: 87 PMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG----ALQEE 142 ++ L+ + + + +LI + E +L + ++ E Sbjct: 89 LSFCR--------HPHLVSLIGFCDERNEMILIYKYMEN-GNLKRHLYGSDLPTMSMSWE 139 Query: 143 LARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA----LLKDTVY 198 + + H ++HRD+K NIL+D N K+ DFG L + + Sbjct: 140 QRLEICIGAARGLHYLHTRAIIHRDVKSINILLDENF-VPKITDFGISKKGTELDQTHLS 198 Query: 199 TDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC 237 T GT Y PE+ R + V+S G++L++++C Sbjct: 199 TVVKGTLGYIDPEYFIKGRL-TEKSDVYSFGVVLFEVLC 236 >3MDY-A nrPDB Length = 337 Score = 136 bits (344), Expect = 1e-32, Method: Composition-based stats. Identities = 62/304 (20%), Positives = 108/304 (35%), Gaps = 65/304 (21%) Query: 34 LESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLL 93 + Q Q+ +G G +G V+ G VA+K + W E + Sbjct: 35 IAKQIQMVKQIGKGRYGEVWMGKWR--GEKVAVKVFFTTEEASW---------FRETEIY 83 Query: 94 KKVSSGFSGVIRLLDWFERP----DSFVLILERPEPVQDLFDFITERGALQEELARSFFW 149 + V ++ + + LI + E L+D++ L + + Sbjct: 84 QTVLMRHENILGFIAADIKGTGSWTQLYLITDYHEN-GSLYDYLKST-TLDAKSMLKLAY 141 Query: 150 QVLEAVRHCH--------NCGVLHRDIKDENILIDLNRGELKLIDFGSG-ALLKDTVYTD 200 + + H H + HRD+K +NIL+ N G + D G + DT D Sbjct: 142 SSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKN-GTCCIADLGLAVKFISDTNEVD 200 Query: 201 -----FDGTRVYSPPEWI--RYHRYHGRS---AAVWSLGILLYD----MVCG------DI 240 GT+ Y PPE + +R H +S A ++S G++L++ V G + Sbjct: 201 IPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQL 260 Query: 241 PFEHDEE-------------IIRGQVFFRQRVSSE-----CQHLIRWCLALRPSDRPTFE 282 P+ I + + F R SS+ L+ C A P+ R T Sbjct: 261 PYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTAL 320 Query: 283 EIQN 286 ++ Sbjct: 321 RVKK 324 >5X18-A nrPDB Length = 295 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 50/249 (20%), Positives = 98/249 (39%), Gaps = 33/249 (13%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 Y++G +G G FG ++ G + + +PVAIK ++ E K + Sbjct: 8 HYKIGKKIGEGSFGVLFEGTNMINGVPVAIKF--------EPRKTEAPQLRDEYKTYKIL 59 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITERGALQEELARSFFWQVLEAV 155 + G + + + +L+++ P ++DLFD+ + + Q++ + Sbjct: 60 N-GTPNIPYAYYFGQEGLHNILVIDLLGPSLEDLFDWCGRK--FSVKTVVQVAVQMITLI 116 Query: 156 RHCHNCGVLHRDIKDENILIDL----NRGELKLIDFGSGALLKDT---------VYTDFD 202 H +++RDIK +N LI + + LIDFG +D Sbjct: 117 EDLHAHDLIYRDIKPDNFLIGRPGQPDANNIHLIDFGMAKQYRDPKTKQHIPYREKKSLS 176 Query: 203 GTRVYSPPEWIRYH--RYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR---Q 257 GT Y I H R R + +LG + + + G +P++ + Q + + + Sbjct: 177 GTARYMS---INTHLGREQSRRDDMEALGHVFFYFLRGHLPWQGLKAPNNKQKYEKIGEK 233 Query: 258 RVSSECQHL 266 + S+ L Sbjct: 234 KRSTNVYDL 242 >4XHH-A nrPDB Length = 403 Score = 136 bits (343), Expect = 1e-32, Method: Composition-based stats. Identities = 60/294 (20%), Positives = 118/294 (40%), Gaps = 40/294 (13%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 ++++G +GSG FG +Y G + VAI+ + S +L +RV K Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAIR--LESIRSRHPQLDYESRVY-------KY 58 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITERGALQEELARSFFWQVLEAV 155 SG G+ + + + ++++ P ++DLF++ + + + + + Q++ V Sbjct: 59 LSGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRKFSFKTVIMLAL--QMICRV 116 Query: 156 RHCHNCGVLHRDIKDENILIDLNR--GELKLIDFGSGALLKD---------TVYTDFDGT 204 ++ H +HRDIK +N L+ + R + +IDFG +D GT Sbjct: 117 QYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGT 176 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR-------- 256 Y+ R + SLG +L G +P++ + + Q + R Sbjct: 177 ARYASVNTHLGIE-QSRRDDLESLGYMLIYFCKGSLPWQGLKATTKKQKYDRILEKKLCI 235 Query: 257 ------QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHL 304 + E + +C L+ +RP + + +D+ + E HL Sbjct: 236 SVETLCAGLPLEFSEYMNYCRNLKFDERPDYLYLAR--LFKDLSIKLEYHNDHL 287 >4MWI-A nrPDB Length = 294 Score = 136 bits (342), Expect = 1e-32, Method: Composition-based stats. Identities = 54/245 (22%), Positives = 92/245 (37%), Gaps = 27/245 (11%) Query: 63 PVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFER----PDSFVL 118 PVAIK +K + + E+ +KK S ++R+ P F + Sbjct: 49 PVAIKVFKKLQAGSIAIV--RQTFNKEIKTMKKFES--PNILRIFGICIDETVTPPQFSI 104 Query: 119 ILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNC--GVLHRDIKDENILID 176 ++E E + L + + L + H+ LH I+ N L+ Sbjct: 105 VMEYCE-LGTLRELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVT 163 Query: 177 LNRGELKLIDFGSGA------LLKDTVYTDFDGTRVYSPPEWIRYHRY-HGRSAAVWSLG 229 ++KL F L TD + Y P+ + Y + + ++S G Sbjct: 164 QGY-QVKLAGFELRKTQTSMSLGTTREKTDRVKSTAYLSPQELEDVFYQYDVKSEIYSFG 222 Query: 230 ILLYDMVCGDIPFEH--------DEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTF 281 I+L+++ GDIPF+ + R Q + SE + +I C A PS RP+ Sbjct: 223 IVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSV 282 Query: 282 EEIQN 286 +EI Sbjct: 283 DEILK 287 >5J0A-A nrPDB Length = 300 Score = 131 bits (329), Expect = 5e-31, Method: Composition-based stats. Identities = 58/282 (20%), Positives = 100/282 (35%), Gaps = 47/282 (16%) Query: 48 GFGS---VYSGIRVSDNL---PVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS 101 GFG+ VY R L P A+K + +D R+ E +LK + Sbjct: 18 GFGTGVNVYLMKRSPRGLSHSPWAVKKIN-PICNDHYRSVYQKRLMDEAKILKSLHH--P 74 Query: 102 GVIRLLDWFE-RPDSFVLILERPEPVQDLFDFITER-----GALQEELARSFFWQVLEAV 155 ++ + E S L +E + L D I ER + + + Sbjct: 75 NIVGYRAFTEANDGSLCLAMEY-GGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGL 133 Query: 156 RHCHN-CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTD-----FDGTRVYSP 209 ++ H +LH DIK N++I + +K+ D G L + + + GT + P Sbjct: 134 KYLHQEKKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMEVTDPEACYIGTEPWKP 193 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIP--------------FEH---DEEIIRGQ 252 E + + A +++ G+ L++M+ IP F+ D+E Sbjct: 194 KEAVEENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAYYAA 253 Query: 253 VFFRQRVSSE--------CQHLIRWCLALRPSDRPTFEEIQN 286 + R ++ E L C P DRP+ I Sbjct: 254 LGTRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVE 295 >1CSN-A nrPDB Length = 298 Score = 130 bits (328), Expect = 6e-31, Method: Composition-based stats. Identities = 59/250 (23%), Positives = 106/250 (42%), Gaps = 33/250 (13%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 Y+VG +G G FG ++ G + +N VAIK + R SD +L + R K+ Sbjct: 11 HYKVGRRIGEGSFGVIFEGTNLLNNQQVAIKF--EPRRSDAPQLRDEYRTY-------KL 61 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITERGALQEELARSFFWQVLEAV 155 +G +G+ + + + VL+++ P ++DL D + + Q+L V Sbjct: 62 LAGCTGIPNVYYFGQEGLHNVLVIDLLGPSLEDLLDLCGRK--FSVKTVAMAAKQMLARV 119 Query: 156 RHCHNCGVLHRDIKDENILI----DLNRGELKLIDFGSGALLKDTVY---------TDFD 202 + H +++RDIK +N LI N + ++DFG +D V + Sbjct: 120 QSIHEKSLVYRDIKPDNFLIGRPNSKNANMIYVVDFGMVKFYRDPVTKQHIPYREKKNLS 179 Query: 203 GTRVYSPPEWIRYH--RYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR---Q 257 GT Y I H R R + +LG + + G +P++ + Q + R + Sbjct: 180 GTARYMS---INTHLGREQSRRDDLEALGHVFMYFLRGSLPWQGLKAATNKQKYERIGEK 236 Query: 258 RVSSECQHLI 267 + S+ + L Sbjct: 237 KQSTPLRELC 246 >2CMW-A nrPDB Length = 310 Score = 130 bits (328), Expect = 7e-31, Method: Composition-based stats. Identities = 56/289 (19%), Positives = 109/289 (37%), Gaps = 45/289 (15%) Query: 39 QVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSS 98 +VG +G G FG + G + N VAIK ++ +E K++ S Sbjct: 3 RVGKKIGCGNFGELRLGKNLYTNEYVAIKL--------EPIKSRAPQLHLEYRFYKQLGS 54 Query: 99 GFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITERGALQEELARSFFWQVLEAVRH 157 G+ ++ + ++LE P ++DLFD L+ L + Q+L + + Sbjct: 55 AGEGLPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAI--QLLSRMEY 112 Query: 158 CHNCGVLHRDIKDENILI----DLNRGELKLIDFGSGALLKDT---------VYTDFDGT 204 H+ +++RD+K EN LI + + +IDFG D + GT Sbjct: 113 VHSKNLIYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGT 172 Query: 205 RVYSPPEWIRYH--RYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR------ 256 Y I H + R + +LG + + G +P++ + + + + Sbjct: 173 ARYMS---INTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKR 229 Query: 257 --------QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQ 297 + E +R+ L ++P +E ++ D+ + Sbjct: 230 NTPIEALCENFPEEMATYLRYVRRLDFFEKPDYEYLRT--LFTDLFEKK 276 >3G2F-A nrPDB Length = 336 Score = 130 bits (327), Expect = 9e-31, Method: Composition-based stats. Identities = 51/317 (16%), Positives = 96/317 (30%), Gaps = 76/317 (23%) Query: 28 GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVP 87 E ++ L+G G +G+VY G D PVA+K N Sbjct: 5 ASEPSLDLDNLKLLELIGRGRYGAVYKG--SLDERPVAVKVFS---------FANRQNFI 53 Query: 88 MEVVLLKKVSSGFSGVIRLLDWFERPD-----SFVLILERPEPVQDLFDFITERGALQEE 142 E + + + R + ER ++L++E P L +++ + Sbjct: 54 NEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYY-PNGSLCKYLSLHTS-DWV 111 Query: 143 LARSFFWQVLEAVRHCH---------NCGVLHRDIKDENILIDLNRGELKLIDFGSGALL 193 + V + + H + HRD+ N+L+ N G + DFG L Sbjct: 112 SSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLV-KNDGTCVISDFGLSMRL 170 Query: 194 ----------KDTVYTDFDGTRVYSPPEWIRY------HRYHGRSAAVWSLGILLYDMV- 236 +D GT Y PE + + +++LG++ +++ Sbjct: 171 TGNRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFM 230 Query: 237 ---------------------CGDIPFEHDEEIIRGQVFFRQRVSS----------ECQH 265 G+ P D +++ + R + + Sbjct: 231 RCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKE 290 Query: 266 LIRWCLALRPSDRPTFE 282 I C R T + Sbjct: 291 TIEDCWDQDAEARLTAQ 307 >1PY5-A nrPDB Length = 326 Score = 130 bits (326), Expect = 1e-30, Method: Composition-based stats. Identities = 49/298 (16%), Positives = 94/298 (31%), Gaps = 65/298 (21%) Query: 40 VGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 99 + +G G FG V+ G VA+K W E + + V Sbjct: 33 LQESIGKGRFGEVWRGKWR--GEEVAVKIFSSREERSW---------FREAEIYQTVMLR 81 Query: 100 FSGVIRLLDWFERPD----SFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAV 155 ++ + + + L+ + E LFD++ E + + + Sbjct: 82 HENILGFIAADNKDNGTWTQLWLVSDYHE-HGSLFDYLNRYTVTVEGMIK-LALSTASGL 139 Query: 156 RHCH--------NCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK------DTVYTDF 201 H H + HRD+K +NIL+ N G + D G D Sbjct: 140 AHLHMEIVGTQGKPAIAHRDLKSKNILVKKN-GTCCIADLGLAVRHDSATDTIDIAPNHR 198 Query: 202 DGTRVYSPPEW----IRYHRYHG-RSAAVWSLGILLYDMVCG----------DIPFEH-- 244 GT+ Y PE I + + A ++++G++ +++ +P+ Sbjct: 199 VGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLV 258 Query: 245 -------DEEIIRGQVFFRQRVS---SECQHL------IRWCLALRPSDRPTFEEIQN 286 + + + R + C+ L +R C + R T I+ Sbjct: 259 PSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKK 316 >4JRN-A nrPDB Length = 372 Score = 129 bits (324), Expect = 2e-30, Method: Composition-based stats. Identities = 63/270 (23%), Positives = 98/270 (36%), Gaps = 35/270 (12%) Query: 41 GPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTR--------------- 85 G LGSGGF +VY V N +A+K ++ + + R Sbjct: 73 GAPLGSGGFATVYEATDVETNEELAVKVFMSEKEPTDETMLDLQRESSCYRNFSLAKTAK 132 Query: 86 ---------VPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI--- 133 VP +VV+L+ + VI L + P+ F+L++ + + ++ Sbjct: 133 DAQESCRFMVPSDVVMLEGQPASTEVVIGLTTRWV-PNYFLLMMRAEADMSKVISWVFGD 191 Query: 134 --TERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA 191 + + Q ++ V + G++H DIK N L+ L G L L DFG+ Sbjct: 192 ASVNKSEFGLVVRMYLSSQAIKLVANVQAQGIVHTDIKPANFLL-LKDGRLFLGDFGTYR 250 Query: 192 LLKDTVYTDFDGTRVYSPPE--WIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEII 249 + + GT Y PPE + + W LGI LY + C + P D Sbjct: 251 I--NNSVGRAIGTPGYEPPERPFQATGITYTFPTDAWQLGITLYCIWCKERPTPADGIWD 308 Query: 250 RGQVFFRQRVSSECQHLIRWCLALRPSDRP 279 Q LIR L P R Sbjct: 309 YLHFADCPSTPELVQDLIRSLLNRDPQKRM 338 >5E8V-A nrPDB Length = 316 Score = 128 bits (323), Expect = 3e-30, Method: Composition-based stats. Identities = 56/319 (17%), Positives = 96/319 (30%), Gaps = 76/319 (23%) Query: 19 DLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDN----LPVAIKHVEKDRI 74 +H T+L P ++ L+G G F VY + VA+K Sbjct: 2 HMHNTELLP----------IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFP---- 47 Query: 75 SDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSF---VLILERPEPVQDLFD 131 E + ++ +++ L ER ++ +L + Sbjct: 48 -----YEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQE 102 Query: 132 FITERGALQEELARSFFWQVLEAVRHCHN---------CGVLHRDIKDENILIDLNRGEL 182 ++T + E R + + H H+ ++HRD+K NIL+ N Sbjct: 103 YLTRH-VISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILV-KNDLTC 160 Query: 183 KLIDFGSGALLKDTVYTD------FDGTRVYSPPEWIRY-----HRYHGRSAAVWSLGIL 231 L DFG L T+ D GT Y PE + + + V+S+ ++ Sbjct: 161 CLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLASAMNLENVESFKQTDVYSMALV 220 Query: 232 LYDMVCG----------DIPF-----EHDEEIIRGQVFFRQRVSSECQHL---------- 266 L++M + PF EH E Sbjct: 221 LWEMTSRCNAVGEVKDYEPPFGSKVREHPCVASMADNVLADAGRPEIPSFWLNHQGIQMV 280 Query: 267 ---IRWCLALRPSDRPTFE 282 + C P R T + Sbjct: 281 CETLTECWDHDPEARLTAQ 299 >5X1R-A nrPDB Length = 302 Score = 128 bits (322), Expect = 3e-30, Method: Composition-based stats. Identities = 56/276 (20%), Positives = 99/276 (35%), Gaps = 28/276 (10%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGE---------------L 80 +++++ +G GGFG VY +AIK ++ + Sbjct: 21 NEFEIQEAIGEGGFGIVYRAYDHQLERTIAIKEYMPTSLAKRNDDLSIGLRGERFGKTFQ 80 Query: 81 PNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQ 140 E LL + S G++ +L ++E + + + + + Sbjct: 81 AGLNSFIQEARLLARFSH--PGLLHVLRFWEENGTAYMGTQFYSGTTLKNLQAQQPEKID 138 Query: 141 EELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY-- 198 E R + A+ H G LHRDI +NI I ++ + L+DFGS + Sbjct: 139 EAWIRRLLPPLFSAINTIHQEGYLHRDISLDNIQIQESQLPV-LLDFGSARKEIGNLSDE 197 Query: 199 TDFDGTRVYSPPEWI--RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF- 255 T+ ++P E G +++LG +L+ ++ G P I Sbjct: 198 TEIVLKPGFAPIEQYTENSDGEQGPWTDIYALGAVLHTLIVGSPPPVSVVRSIEDSYQPL 257 Query: 256 ----RQRVSSECQHLIRWCLALRPSDRP-TFEEIQN 286 S E + LAL+P DRP T +E+ Sbjct: 258 TERRPAGYSPELLRTVDRALALKPEDRPQTIDEMAE 293 >4XHL-A nrPDB Length = 394 Score = 127 bits (319), Expect = 6e-30, Method: Composition-based stats. Identities = 59/294 (20%), Positives = 117/294 (39%), Gaps = 40/294 (13%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 ++++G +GSG FG +Y G + VAI+ + S +L +RV Sbjct: 8 KFRIGRKIGSGSFGDIYHGTNLISGEEVAIR--LESIRSRHPQLDYESRVYR-------Y 58 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITERGALQEELARSFFWQVLEAV 155 SG G+ + + + ++++ P ++DLF++ R + + + + Q+ + Sbjct: 59 LSGGVGIPFIRWFGREGEYNAMVIDLLGPSLEDLFNYCHRRFSFKTVIMLAL--QMFCRI 116 Query: 156 RHCHNCGVLHRDIKDENILIDLNR--GELKLIDFGSGALLKD---------TVYTDFDGT 204 ++ H +HRDIK +N L+ + R + +IDFG +D GT Sbjct: 117 QYIHGRSFIHRDIKPDNFLMGVGRRGSTVHVIDFGLSKKYRDFNTHRHIPYRENKSLTGT 176 Query: 205 RVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFR-------- 256 Y+ R + SLG +L G +P++ + + Q + R Sbjct: 177 ARYASVNTHLGIE-QSRRDDLESLGYVLIYFCKGSLPWQGLKATTKKQKYDRIMEKKLNV 235 Query: 257 ------QRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHL 304 + E Q + +C L+ ++P + + +D+ + E HL Sbjct: 236 SVETLCSGLPLEFQEYMAYCKNLKFDEKPDYLFLAR--LFKDLSIKLEYHNDHL 287 >4RT7-A nrPDB Length = 415 Score = 127 bits (319), Expect = 7e-30, Method: Composition-based stats. Identities = 36/161 (22%), Positives = 68/161 (42%), Gaps = 15/161 (9%) Query: 137 GALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA-LLKD 195 L E F +QV + + +HRD+ N+L+ + +K+ DFG ++ D Sbjct: 238 NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK-VVKICDFGLARDIMSD 296 Query: 196 TVYTDFDGTRV---YSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDE----- 246 + Y R+ + PE + + + + VWS GILL+++ G P+ Sbjct: 297 SNYVVRGNARLPVKWMAPESL-FEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANF 355 Query: 247 -EIIRGQVFFRQRV--SSECQHLIRWCLALRPSDRPTFEEI 284 ++I+ Q + E +++ C A RP+F + Sbjct: 356 YKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNL 396 Score = 80.7 bits (198), Expect = 8e-16, Method: Composition-based stats. Identities = 23/113 (20%), Positives = 46/113 (40%), Gaps = 12/113 (10%) Query: 30 EKEPLESQYQVGPLLGSGGFGSVYSGI-----RVSDNLPVAIKHVEKDRISDWGELPNGT 84 + E + G +LGSG FG V + + ++ VA+K +++ S E Sbjct: 59 KWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREA---- 114 Query: 85 RVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG 137 + E+ ++ ++ S ++ LL LI E DL +++ + Sbjct: 115 -LMSELKMMTQLGS-HENIVNLLGACTLSGPIYLIFEYCC-YGDLLNYLRSKR 164 >2WTK-B nrPDB Length = 373 Score = 126 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 50/343 (14%), Positives = 107/343 (31%), Gaps = 77/343 (22%) Query: 36 SQYQVGPLLGSGGFG---SVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVL 92 Y++ ++G G F +V V ++ + + S+ T + E+ + Sbjct: 9 GCYELLTVIGKG-FEDLMTVNLARYKPTGEYVTVRRINLEACSN----EMVTFLQGELHV 63 Query: 93 LKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITER--GALQEELARSFFWQ 150 K + ++ F + ++ D I + E Sbjct: 64 SKLFNH--PNIVPYRATFIADNELWVVTSFMA-YGSAKDLICTHFMDGMNELAIAYILQG 120 Query: 151 VLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDF---------GSGALLKDTVYTDF 201 VL+A+ + H+ G +HR +K +ILI ++ G++ L G + Sbjct: 121 VLKALDYIHHMGYVHRSVKASHILISVD-GKVYLSGLRSNLSMISHGQRQRVVHDFPKYS 179 Query: 202 DGTRVYSPPEWIRYH-RYHGRSAAVWSLGI-------------------LLYDMVCGDIP 241 + PE ++ + + + + ++S+GI +L + + G +P Sbjct: 180 VKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVP 239 Query: 242 FEHDEEIIRGQVF---------------------------------FRQRVSSECQHLIR 268 D I + + + S H + Sbjct: 240 CLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVE 299 Query: 269 WCLALRPSDRPTFEEIQNHPWMQDVLLPQ-ETAEIHLHSLSPG 310 CL P RP+ + NH + + + E L ++P Sbjct: 300 QCLQRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPI 342 >2CHL-A nrPDB Length = 351 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 49/226 (21%), Positives = 93/226 (41%), Gaps = 30/226 (13%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 ++VG +G G FG + G + N VAIK ++ +E K++ Sbjct: 31 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKL--------EPMKSRAPQLHLEYRFYKQL 82 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITERGALQEELARSFFWQVLEAV 155 SG G+ ++ + ++LE P ++DLFD +L+ L + Q++ + Sbjct: 83 GSG-DGIPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAI--QLISRM 139 Query: 156 RHCHNCGVLHRDIKDENILI----DLNRGELKLIDFGSGALLKDT---------VYTDFD 202 + H+ +++RD+K EN LI + + + +IDF D + Sbjct: 140 EYVHSKNLIYRDVKPENFLIGRPGNKTQQVIHIIDFALAKEYIDPETKKHIPYREHKSLT 199 Query: 203 GTRVYSPPEWIRYH--RYHGRSAAVWSLGILLYDMVCGDIPFEHDE 246 GT Y I H + R + +LG + + G +P++ + Sbjct: 200 GTARYMS---INTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLK 242 >2C47-A nrPDB Length = 313 Score = 126 bits (317), Expect = 1e-29, Method: Composition-based stats. Identities = 54/280 (19%), Positives = 107/280 (38%), Gaps = 44/280 (15%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 ++VG +G G FG + G + N VAIK ++ +E K++ Sbjct: 5 NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKL--------EPIKSRAPQLHLEYRFYKQL 56 Query: 97 SSGFSGVIRLLDWFERPDSFVLILERPEP-VQDLFDFITERGALQEELARSFFWQVLEAV 155 S+ GV ++ + ++LE P ++DLFD L+ L + Q++ + Sbjct: 57 SA-TEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAI--QLITRM 113 Query: 156 RHCHNCGVLHRDIKDENILI----DLNRGELKLIDFGSGALLKDT---------VYTDFD 202 + H +++RD+K EN L+ + + +IDFG D + Sbjct: 114 EYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLT 173 Query: 203 GTRVYSPPEWIRYH--RYHGRSAAVWSLGILLYDMVCGDIPFEHD---------EEIIRG 251 GT Y I H + R + +LG + + G +P++ ++I Sbjct: 174 GTARYMS---INTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDT 230 Query: 252 QVFFR-----QRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 + + E +R+ L ++P ++ ++ Sbjct: 231 KRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRK 270 >6BFN-A nrPDB Length = 342 Score = 125 bits (315), Expect = 2e-29, Method: Composition-based stats. Identities = 42/215 (19%), Positives = 79/215 (36%), Gaps = 26/215 (12%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 +G GGFG VY + + A+K ++++ +W + EV L + Sbjct: 29 KIGEGGFGCVYRAVMRNT--VYAVKRLKENADLEWTAVKQS--FLTEVEQLSRFRH--PN 82 Query: 103 VIRLLDWFERPDSFVLILERPEPVQDLFDFITER----GALQEELARSFFWQVLEAVRHC 158 ++ + + + L+ P L D + + L A++ Sbjct: 83 IVDFAGYCAQNGFYCLVYGFL-PNGSLEDRLHCQTQACPPLSWPQRLDILLGTARAIQFL 141 Query: 159 H--NCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT-----------DFDGTR 205 H + ++H DIK N+L+D KL DFG + + GT Sbjct: 142 HQDSPSLIHGDIKSSNVLLDERLTP-KLGDFGLARFSRFAGSSPSQSSMVARTQTVRGTL 200 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI 240 Y P E+I+ R + +S G+++ + + G Sbjct: 201 AYLPEEYIKTGRLAVDT-DTFSFGVVVLETLAGQR 234 >2PZI-A nrPDB Length = 681 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 53/267 (19%), Positives = 106/267 (39%), Gaps = 26/267 (9%) Query: 25 LAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVS-DNLPVAIK-HVEKDRISDWGELPN 82 L + + QY+V + GG G +Y + + + PV +K V Sbjct: 69 LPQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMA 128 Query: 83 GTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSF-----VLILERPEPVQDLFDFITERG 137 + EVV ++++ ++ E D +++E Q L ++ Sbjct: 129 ERQFLAEVV--------HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGG-QSLKR--SKGQ 177 Query: 138 ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV 197 L A ++ ++L A+ + H+ G+++ D+K ENI++ +LKLID G+ + + Sbjct: 178 KLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE--QLKLIDLGAVSRINSFG 235 Query: 198 YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ 257 Y GT + PE +R + ++++G L + D+P + + Sbjct: 236 Y--LYGTPGFQAPEIVRTGP--TVATDIYTVGRTLAA-LTLDLPTRNGRYVDGLPEDDPV 290 Query: 258 RVSSECQH-LIRWCLALRPSDRPTFEE 283 + + L+R + P R T E Sbjct: 291 LKTYDSYGRLLRRAIDPDPRQRFTTAE 317 >4Y12-A nrPDB Length = 375 Score = 119 bits (298), Expect = 2e-27, Method: Composition-based stats. Identities = 53/267 (19%), Positives = 106/267 (39%), Gaps = 26/267 (9%) Query: 25 LAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVS-DNLPVAIK-HVEKDRISDWGELPN 82 L + + QY+V + GG G +Y + + + PV +K V Sbjct: 108 LPQLNPGDIVAGQYEVKGCIAHGGLGWIYLALDRNVNGRPVVLKGLVHSGDAEAQAMAMA 167 Query: 83 GTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSF-----VLILERPEPVQDLFDFITERG 137 + EVV ++++ ++ E D +++E Q L ++ Sbjct: 168 ERQFLAEVV--------HPSIVQIFNFVEHTDRHGDPVGYIVMEYVGG-QSLKR--SKGQ 216 Query: 138 ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV 197 L A ++ ++L A+ + H+ G+++ D+K ENI++ +LKLID G+ + + Sbjct: 217 KLPVAEAIAYLLEILPALSYLHSIGLVYNDLKPENIMLTEE--QLKLIDLGAVSRINSFG 274 Query: 198 YTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ 257 Y GT + PE +R + ++++G L + D+P + + Sbjct: 275 Y--LYGTPGFQAPEIVRTGP--TVATDIYTVGRTLAA-LTLDLPTRNGRYVDGLPEDDPV 329 Query: 258 RVSSECQH-LIRWCLALRPSDRPTFEE 283 + + L+R + P R T E Sbjct: 330 LKTYDSYGRLLRRAIDPDPRQRFTTAE 356 >4NT4-A nrPDB Length = 312 Score = 118 bits (296), Expect = 4e-27, Method: Composition-based stats. Identities = 49/231 (21%), Positives = 89/231 (38%), Gaps = 34/231 (14%) Query: 37 QYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKV 96 ++VG +G G FG + G + +N VAIK ++ +E K + Sbjct: 13 NFRVGKKIGCGNFGELRLGKNLYNNEHVAIKM--------EPMKSKAPQLHLEYRFYKLL 64 Query: 97 SSGFSG----VIRLLDWFERPDSFV-LILERPE-PVQDLFDFITERGALQEELARSFFWQ 150 S + R+ + ++LE ++DLF+ + +L+ L Q Sbjct: 65 GSHADNAPDGIPRIYHLGTCGGRYNAMVLELLGLSLEDLFNICARKFSLKTVLM--IAKQ 122 Query: 151 VLEAVRHCHNCGVLHRDIKDENILI----DLNRGELKLIDFGSGALLKD---------TV 197 +L + + H+ +++RD+K EN LI + +IDFG D Sbjct: 123 LLHRIEYVHSRHLIYRDVKPENFLIGRTSTKREKIIHIIDFGLAKEYIDLDTNRHIPYRE 182 Query: 198 YTDFDGTRVYSPPEWIRYH--RYHGRSAAVWSLGILLYDMVCGDIPFEHDE 246 + GT Y I H R R + +LG + + G +P++ + Sbjct: 183 HKSLTGTARYMS---INTHMGREQSRRDDLEALGHMFMYFLRGSLPWQGLK 230 >5USZ-A nrPDB Length = 289 Score = 116 bits (291), Expect = 1e-26, Method: Composition-based stats. Identities = 48/277 (17%), Positives = 95/277 (34%), Gaps = 36/277 (12%) Query: 42 PLLGSGGFGSVYSGIRVSDN-------LPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 LG G F ++ G+R V +K ++K + ++ Sbjct: 14 ESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAA------SMMS 67 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA-LQEELARSFFWQVLE 153 K+S ++ D +L+ E + L ++ + + Q+ Sbjct: 68 KLSHKH--LVLNYGVCVCGDENILVQEFVK-FGSLDTYLKKNKNCINILWKLEVAKQLAA 124 Query: 154 AVRHCHNCGVLHRDIKDENILIDLNRGE-------LKLIDFGSG-ALLKDTVYTDFDGTR 205 A+ ++H ++ +NIL+ +KL D G +L + + Sbjct: 125 AMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERI--- 181 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEEIIRGQVFF-----RQRV 259 + PPE I + + WS G L+++ GD P + + Q + Sbjct: 182 PWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPK 241 Query: 260 SSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLP 296 ++E +LI C+ P RP+F I + + P Sbjct: 242 AAELANLINNCMDYEPDHRPSFRAIIRD--LNSLFTP 276 >4L00-A nrPDB Length = 304 Score = 114 bits (287), Expect = 4e-26, Method: Composition-based stats. Identities = 49/266 (18%), Positives = 94/266 (35%), Gaps = 26/266 (9%) Query: 41 GPLLGSGGFGSVYSGI------RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 G LG G +YSG + IK + K + D +++ Sbjct: 30 GEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILK--VLDPSHRDISLAFFEAASMMR 87 Query: 95 KVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 +VS ++ L R +++ E E + L Q+ A Sbjct: 88 QVSHKH--IVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASA 145 Query: 155 VRHCHNCGVLHRDIKDENILIDLNRGE------LKLIDFGSGALLKDTVYTDFDGTRVYS 208 + + + ++H ++ +N+L+ + +KL D G + + + Sbjct: 146 LSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQ--ECIERIPWI 203 Query: 209 PPEWIRYHRYHGRSAAVWSLGILLYDMVC-GDIPFEHDEEIIRGQVFFRQRV------SS 261 PE + + +A WS G L+++ G+IP + D+ +I + F+ R Sbjct: 204 APECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLK-DKTLIEKERFYESRCRPVTPSCK 262 Query: 262 ECQHLIRWCLALRPSDRPTFEEIQNH 287 E L+ C+ P+ RP F I Sbjct: 263 ELADLMTRCMNYDPNQRPFFRAIMRD 288 >3SOC-A nrPDB Length = 322 Score = 114 bits (286), Expect = 5e-26, Method: Composition-based stats. Identities = 48/294 (16%), Positives = 88/294 (29%), Gaps = 65/294 (22%) Query: 39 QVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSS 98 Q+ + G FG V+ + N VA+K + + E + Sbjct: 27 QLLEVKARGRFGCVWKAQLL--NEYVAVKIFP---------IQDKQSWQNEYEVYSLPGM 75 Query: 99 GFSGVIRLLDWFERPDS----FVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 +++ + +R S LI E L DF+ + + Sbjct: 76 KHENILQFIGAEKRGTSVDVDLWLITAFHEK-GSLSDFLKAN-VVSWNELCHIAETMARG 133 Query: 155 VRHCHN----------CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV----YTD 200 + + H + HRDIK +N+L+ N + DFG + Sbjct: 134 LAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTAC-IADFGLALKFEAGKSAGDTHG 192 Query: 201 FDGTRVYSPPEW----IRYHRYHGRSAAVWSLGILLYDMVCGD-----------IPFE-- 243 GTR Y PE I + R ++++G++L+++ +PFE Sbjct: 193 QVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEE 252 Query: 244 ---HDEEIIRGQVFFRQRVSSECQHL-------------IRWCLALRPSDRPTF 281 H +V ++ + I C R + Sbjct: 253 IGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSA 306 >3REP-A nrPDB Length = 271 Score = 113 bits (283), Expect = 1e-25, Method: Composition-based stats. Identities = 44/250 (17%), Positives = 89/250 (35%), Gaps = 31/250 (12%) Query: 50 GSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDW 109 G ++ G +++ V K ++ S P L+ S V+ +L Sbjct: 24 GELWKGRWQGNDIVV--KVLKVRDWSTRKSRDFNEECPR----LRIFSH--PNVLPVLGA 75 Query: 110 FERPD--SFVLILERPEPVQDLFDFITE--RGALQEELARSFFWQVLEAVRHCHN-CGVL 164 + P LI P L++ + E + + A F + + H ++ Sbjct: 76 CQSPPAPHPTLITHWM-PYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLI 134 Query: 165 HR-DIKDENILIDLN-RGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHG-- 220 R + +++ID + + + D +Y + PE ++ Sbjct: 135 PRHALNSRSVMIDEDMTARISMADVKFSFQSPGRMYA-----PAWVAPEALQKKPEDTNR 189 Query: 221 RSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQV--------FFRQRVSSECQHLIRWCLA 272 RSA +WS +LL+++V ++PF + G +S L++ C+ Sbjct: 190 RSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVSKLMKICMN 249 Query: 273 LRPSDRPTFE 282 P+ RP F+ Sbjct: 250 EDPAKRPKFD 259 >5OAT-A nrPDB Length = 411 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 54/306 (17%), Positives = 91/306 (29%), Gaps = 64/306 (20%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSD-----NLPVAIKHVE----------------KDRI 74 + +G + G G VYS D P A+K + ++ + Sbjct: 11 NDLSLGKPIAKGTNGVVYSAKVKDDETDDNKYPFALKMMFNYDIQENSMEILKAMYRETV 70 Query: 75 SDWGELPNGTRVPMEVVLLKKVSS--GFSGVIRLLDWFER------PDSFVLILERPEPV 126 N E+ L + ++ + F P E Sbjct: 71 PARMYYSNHDLNNWEIELANRRKHLPPHPNIVAIFSVFTDLYPAALPPRLHP--EGEGRN 128 Query: 127 QDLFDFITERG---------ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDL 177 LF + A + Q+LE V H G+ HRD+K +N+L+D Sbjct: 129 MSLFLLMKRYDCNLQSFLSTAPSTRTSLLLLAQLLEGVAHMTAHGIAHRDLKSDNLLLDT 188 Query: 178 NRGE---LKLIDFGSGALLKDTVYT--------DFDGTRVYSPPEWIRYHRY------HG 220 + E L + DFG K + D G PE I + Sbjct: 189 SEPESPILVISDFGCCLADKTNGLSLPYTSYEMDKGGNTALMAPEIICQKPGTFSVLNYS 248 Query: 221 RSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFF------RQRVSSECQHLIRWCLALR 274 ++ +W++G + Y++ PF + V + Q L+ L Sbjct: 249 KA-DLWAVGAIAYEIFNCHNPFYGPSRLKNFNYKEGDLPKLPDEVPTVIQALVANLLKRN 307 Query: 275 PSDRPT 280 P+ R Sbjct: 308 PNKRLD 313 >2QLU-A nrPDB Length = 314 Score = 110 bits (275), Expect = 1e-24, Method: Composition-based stats. Identities = 50/288 (17%), Positives = 100/288 (34%), Gaps = 46/288 (15%) Query: 39 QVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSS 98 Q+ + G FG V+ ++D VA+K L + E + Sbjct: 18 QLLEIKARGRFGCVWKAQLMND--FVAVKIFP---------LQDKQSWQSEREIFSTPGM 66 Query: 99 GFSGVIRLLDWFERPDSF----VLILERPEPVQDLFDFITERGALQEELARSFFWQVLEA 154 +++ + +R + LI + L D++ + + Sbjct: 67 KHENLLQFIAAEKRGSNLEVELWLITAFHDK-GSLTDYLKGN-IITWNELCHVAETMSRG 124 Query: 155 VRHCHN-----------CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTV----YT 199 + + H + HRD K +N+L+ + + L DFG + Sbjct: 125 LSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAV-LADFGLAVRFEPGKPPGDTH 183 Query: 200 DFDGTRVYSPPEW----IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEH--DEEIIRGQV 253 GTR Y PE I + R ++++G++L+++V + DE ++ + Sbjct: 184 GQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFEE 243 Query: 254 FFRQRVS-SECQHLIRWCLALRPSDRPTFEEI-QNHPWMQDVLLPQET 299 Q S E Q ++ + RPT ++ HP + + + E Sbjct: 244 EIGQHPSLEELQEVV-----VHKKMRPTIKDHWLKHPGLAQLCVTIEE 286 >5C01-A nrPDB Length = 342 Score = 106 bits (265), Expect = 1e-23, Method: Composition-based stats. Identities = 52/299 (17%), Positives = 94/299 (31%), Gaps = 35/299 (11%) Query: 4 SKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLP 63 +I L+HL +++ +L +P E + L G L Sbjct: 58 KEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPL--------VPGRDRGQELR 109 Query: 64 VAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERP 123 V +K ++ L+ +VS + R +++ E Sbjct: 110 VVLKVLDPSHH------DIALAFYETASLMSQVSHTHLAFV--HGVCVRGPENIMVTEYV 161 Query: 124 EPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILI------DL 177 E ERG + Q+ A+ + N ++H ++ NIL+ + Sbjct: 162 EHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEG 221 Query: 178 NRGELKLID--FGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYH-GRSAAVWSLGILLYD 234 +KL D G GAL ++ + PE + + W G L + Sbjct: 222 TSPFIKLSDPGVGLGALSREERVERI----PWLAPECLPGGANSLSTAMDKWGFGATLLE 277 Query: 235 MVC-GDIPFEHDEEIIRGQVFFRQRV-----SSECQHLIRWCLALRPSDRPTFEEIQNH 287 + G+ P + + + RQ + L CL P+ RP+F I Sbjct: 278 ICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRD 336 >4WOV-A nrPDB Length = 317 Score = 105 bits (263), Expect = 2e-23, Method: Composition-based stats. Identities = 52/299 (17%), Positives = 94/299 (31%), Gaps = 35/299 (11%) Query: 4 SKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLP 63 +I L+HL +++ +L +P E + L G L Sbjct: 35 KEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPL--------VPGRDRGQELR 86 Query: 64 VAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERP 123 V +K ++ L+ +VS + R +++ E Sbjct: 87 VVLKVLDPSHH------DIALAFYETASLMSQVSHTHLAFV--HGVCVRGPENIMVTEYV 138 Query: 124 EPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILI------DL 177 E ERG + Q+ A+ + N ++H ++ NIL+ + Sbjct: 139 EHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEG 198 Query: 178 NRGELKLID--FGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYH-GRSAAVWSLGILLYD 234 +KL D G GAL ++ + PE + + W G L + Sbjct: 199 TSPFIKLSDPGVGLGALSREERVERI----PWLAPECLPGGANSLSTAMDKWGFGATLLE 254 Query: 235 MVC-GDIPFEHDEEIIRGQVFFRQRV-----SSECQHLIRWCLALRPSDRPTFEEIQNH 287 + G+ P + + + RQ + L CL P+ RP+F I Sbjct: 255 ICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRD 313 >5M07-A nrPDB Length = 276 Score = 104 bits (259), Expect = 6e-23, Method: Composition-based stats. Identities = 47/264 (17%), Positives = 87/264 (32%), Gaps = 38/264 (14%) Query: 38 YQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVS 97 Y V +LG+ G VY A+K + +D R E + ++ Sbjct: 32 YTVVRMLGASAMGEVYLVQHPGFPGWQALKVLSPAMAADD---EFRRRFQRETEVAARLF 88 Query: 98 SGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA--LQEELARSFFWQVLEAV 155 ++ + D E + ++ + + D + +R L + V A+ Sbjct: 89 H--PHILEVHDRGEFDGQLWIAMDYVDGI-DATQHMADRFPAVLPVGEVLAIVTAVAGAL 145 Query: 156 RHCHNCGVLHRDIKDENILIDLN---RGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEW 212 + H G+LHRD+ N+++ + L DFG + Y PE Sbjct: 146 DYAHQRGLLHRDVNPANVVLTSQSAGDQRILLADFGIASQ------------PSYPAPEL 193 Query: 213 IRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVS---SECQHL--- 266 GR+ ++L + + G P + ++S + L Sbjct: 194 SAGADVDGRA-DQYALALTAIHLFAGAPPVDRS----HTGPLQPPKLSAFRPDLARLDGV 248 Query: 267 IRWCLALRPSDRPT----FEEIQN 286 + LA P+DR F + N Sbjct: 249 LSRALATAPADRFGSCREFADAMN 272 >4I94-A nrPDB Length = 300 Score = 98.8 bits (245), Expect = 3e-21, Method: Composition-based stats. Identities = 52/244 (21%), Positives = 96/244 (39%), Gaps = 29/244 (11%) Query: 51 SVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWF 110 VY G ++ + +A+K + D + + ++ + + LL Sbjct: 44 VVYKG-KLENQRRIAVKRFNRKSWPDSRQFLEEAKAVGQLR-----NHRMAN---LLGCC 94 Query: 111 ERPDSFVLILERPEPVQDLFDFIT--ERGALQEELARSFFWQVLEAVRHCHNCG-VLHRD 167 + +LI E P + L + E ++ + + +A+ +C + G L+ D Sbjct: 95 YEDEERLLIAEFM-PNETLAKHLFHWESQPMKWAMRLRVALHIAQALEYCTSKGRALYHD 153 Query: 168 IKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWS 227 + +L D + +L FG +D + ++PPE++R R S ++S Sbjct: 154 LNAYRVLFDDDANP-RLSCFGLMKNSRDG--KSYSTNLAFTPPEYLRTGRVTPESV-IYS 209 Query: 228 LGILLYDMVCGD-IPFEHDEEIIRGQV--------FFRQRVSSECQHLIR---WCLALRP 275 G LL D++ G IP H ++IR + Q S + LIR CL P Sbjct: 210 FGTLLLDLLSGKHIPPSHALDLIRDRNIQMLMDSGLEGQFSSDDGTELIRLASRCLQYEP 269 Query: 276 SDRP 279 +RP Sbjct: 270 RERP 273 >6EQI-C nrPDB Length = 433 Score = 98.4 bits (244), Expect = 4e-21, Method: Composition-based stats. Identities = 51/320 (15%), Positives = 103/320 (32%), Gaps = 76/320 (23%) Query: 36 SQYQVGPLLGSGGFGSVYSG---------------------IRVSDNLPVAIKHVEKDRI 74 + +G + G VYS V N +K + ++ + Sbjct: 15 DELDLGEPIAKGCNAVVYSAKLKNVQSNKLAHQLAVKMMFNYDVESNSTAILKAMYRETV 74 Query: 75 SDWGELPNGTRVPME-VVLLKKVSSGFSGVIRLLDWFERPD------------------- 114 N +E + K ++R+ F Sbjct: 75 PAMSYFFNQNLFNIENISDFKIRLPPHPNIVRMYSVFADRIPDLQCNKQLYPEALPPRIN 134 Query: 115 --------SFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHR 166 S L+++R + L +++ ++ + Q+LEAV H + + HR Sbjct: 135 PEGSGRNMSLFLVMKRYDCT--LKEYLRDKTP-NMRSSILLLSQLLEAVAHMNIHNISHR 191 Query: 167 DIKDENILIDLNRGE----LKLIDFGSGALLKDTVYT--------DFDGTRVYSPPEWIR 214 D+K +NIL+DL+ G+ + + DFG K D G R PE Sbjct: 192 DLKSDNILVDLSEGDAYPTIVITDFGCCLCDKQNGLVIPYRSEDQDKGGNRALMAPEIAN 251 Query: 215 YHRYHG-----RSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSE------- 262 + + +W++G + Y++ D PF + + + + + Sbjct: 252 AKPGTFSWLNYKKSDLWAVGAIAYEIFNIDNPFYDKTMKLLSKSYKEEDLPELPDTIPFI 311 Query: 263 CQHLIRWCLALRPSDRPTFE 282 ++L+ L+ + R + Sbjct: 312 IRNLVSNMLSRSTNKRLDCD 331 >5UU1-A nrPDB Length = 324 Score = 94.6 bits (234), Expect = 5e-20, Method: Composition-based stats. Identities = 48/243 (19%), Positives = 97/243 (39%), Gaps = 26/243 (10%) Query: 25 LAPGKEKEPLE-SQYQVGPLLGSGGFGSVYSG----IRVSDNLPVAIKHVEKDRISDWGE 79 GK + +E +Q+ +G +GSGGFG +Y D V +K ++ + E Sbjct: 4 FPEGKVLDDMEGNQWVLGKKIGSGGFGLIYLAFPTNKPEKDARHV-VKVEYQENGPLFSE 62 Query: 80 LPNGTRVPMEVVL---LKKVSSGFSGVIRLLDW----FERPDSFVLILERPEPVQDLFDF 132 L RV + + +++ + G+ F+ +++ER DL Sbjct: 63 LKFYQRVAKKDCIKKWIERKQLDYLGIPLFYGSGLTEFKGRSYRFMVMERLG--IDLQKI 120 Query: 133 ITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILID-LNRGELKLIDFGSG- 190 + G ++ ++L+ + + H +H DIK N+L+ N ++ L D+G Sbjct: 121 SGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSY 180 Query: 191 --------ALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPF 242 ++ +GT ++ + + R + V LG + +CG +P+ Sbjct: 181 RYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVAL-SRRSDVEILGYCMLRWLCGKLPW 239 Query: 243 EHD 245 E + Sbjct: 240 EQN 242 >5UV4-A nrPDB Length = 311 Score = 91.1 bits (225), Expect = 6e-19, Method: Composition-based stats. Identities = 36/211 (17%), Positives = 78/211 (36%), Gaps = 22/211 (10%) Query: 42 PLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS 101 ++G G+ Y + + + +K ++ G + E+ L V Sbjct: 31 EIIGRSCHGTSYKAT-LDNGYMLTVKWLK------EGFAKSKKEFSREIKKLGSVRH--P 81 Query: 102 GVIRL--LDWFERPDSFVLILERPEPVQDLFDFITERG-----ALQEELARSFFWQVLEA 154 ++ L W + ++I + + L +++E L + + Sbjct: 82 NLVPLRGYYWGPKEHERIMISDYAD-ATSLSTYLSEFDERNLPPLSAGQRLNIAIDIARC 140 Query: 155 VRHCHNCGVL-HRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFD---GTRVYSPP 210 + + HN V+ H +IK N+LI + + D+ L+ + G YSPP Sbjct: 141 LDYLHNERVIPHGNIKSSNVLIQNSTPSALVTDYSLHRLMTPIGMAEQVLNAGALGYSPP 200 Query: 211 EWIR-YHRYHGRSAAVWSLGILLYDMVCGDI 240 E+ + V++ G++L +++ G I Sbjct: 201 EFSSTSKPCPSLKSDVYAFGVILLELLTGKI 231 >2RSV-A nrPDB Length = 403 Score = 90.7 bits (224), Expect = 8e-19, Method: Composition-based stats. Identities = 49/290 (16%), Positives = 101/290 (34%), Gaps = 23/290 (7%) Query: 3 LSKINSLAHLRAAPCNDLHATKLAPGKEKEPL-ESQYQVGPLLGSGGFGSVYSG-----I 56 + ++ + R + A + A G+ + + +++VG +G GGFG +Y Sbjct: 8 MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSE 67 Query: 57 RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG---FSGVIRLLDW-FER 112 V + P +K D + EL R + K + + + GV + Sbjct: 68 SVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHD 127 Query: 113 PDSFVLILERPEPVQDLFDFITER--GALQEELARSFFWQVLEAVRHCHNCGVLHRDIKD 170 + + I E + ++L+ + + H +H DIK Sbjct: 128 KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 187 Query: 171 ENILID-LNRGELKLIDFGSG---------ALLKDTVYTDFDGTRVYSPPEWIRYHRYHG 220 N+L++ N ++ L+D+G K+ DGT ++ + Sbjct: 188 SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAP-S 246 Query: 221 RSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWC 270 R + LG + + G +P+E + + + + R L+ C Sbjct: 247 RRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKC 296 >2LAV-A nrPDB Length = 361 Score = 89.6 bits (221), Expect = 2e-18, Method: Composition-based stats. Identities = 49/290 (16%), Positives = 101/290 (34%), Gaps = 23/290 (7%) Query: 3 LSKINSLAHLRAAPCNDLHATKLAPGKEKEPL-ESQYQVGPLLGSGGFGSVYSG-----I 56 + ++ + R + A + A G+ + + +++VG +G GGFG +Y Sbjct: 1 MPRVKAAQAGRQSSAKRHLAEQFAVGEIITDMAKKEWKVGLPIGQGGFGCIYLADMNSSE 60 Query: 57 RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG---FSGVIRLLDW-FER 112 V + P +K D + EL R + K + + + GV + Sbjct: 61 SVGSDAPCVVKVEPSDNGPLFTELKFYQRAAKPEQIQKWIRTRKLKYLGVPKYWGSGLHD 120 Query: 113 PDSFVLILERPEPVQDLFDFITER--GALQEELARSFFWQVLEAVRHCHNCGVLHRDIKD 170 + + I E + ++L+ + + H +H DIK Sbjct: 121 KNGKSYRFMIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKA 180 Query: 171 ENILID-LNRGELKLIDFGSG---------ALLKDTVYTDFDGTRVYSPPEWIRYHRYHG 220 N+L++ N ++ L+D+G K+ DGT ++ + Sbjct: 181 SNLLLNYKNPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAP-S 239 Query: 221 RSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWC 270 R + LG + + G +P+E + + + + R L+ C Sbjct: 240 RRGDLEILGYCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKC 289 >4IX6-A nrPDB Length = 350 Score = 87.6 bits (216), Expect = 7e-18, Method: Composition-based stats. Identities = 64/320 (20%), Positives = 104/320 (32%), Gaps = 80/320 (25%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVL-LKKVSSGFS 101 LGSG FG+V+ G+ D V +K+ + D ++ L V V K + F Sbjct: 27 PLGSGNFGTVFRGVFKGD-QDVVLKNAKADVMAAEELLECEMDVNYHVHANAKGTCARFM 85 Query: 102 GVIRLLDWFERPDSFV-------LILERPEPVQDLFDFITERGALQEELA---------- 144 G I L + L L ++ + + RG A Sbjct: 86 GCIELGA--KDGGEIYNGTLTEGLWLMWANEGENTVEALMRRGTAPLATAMACADATELG 143 Query: 145 --RSFFWQVLEAVRHCHNCGVLHRDIKDEN-ILIDLNRGELKLIDFGSGALL----KDTV 197 + ++L ++ H CGV+HRD+K N I + + G LKLID G+ AL + Sbjct: 144 VTKKAMRELLGSLARLHECGVVHRDVKPANLIAAEKDGGVLKLIDLGAAALCLPLPETLN 203 Query: 198 YTDFDGT--RVY--------SPP--------------EWIRYHRYHGRSAAVWSLGILLY 233 Y DG Y PP E + R+ WS G ++ Sbjct: 204 YYPGDGPADPRYAKADELYLLPPGSPRPTKDNAAKLWEAHKPDRFDS-----WSAGCVML 258 Query: 234 DMVC-------GDIPFEHDEEII-----------RGQVFFRQRVSSEC-----QHLIRWC 270 + G F D + + G+ + + L + Sbjct: 259 QLAVVGLRTDAGLERFLADYKAVGYDVNAFRGEKSGEYGTMDFAALDANGGAGWDLCQRL 318 Query: 271 LALRPSDRPTFEEIQNHPWM 290 + R + E +H + Sbjct: 319 MEAERDARASCEAALSHAFF 338 >4L68-A nrPDB Length = 340 Score = 81.9 bits (201), Expect = 3e-16, Method: Composition-based stats. Identities = 37/199 (18%), Positives = 73/199 (36%), Gaps = 23/199 (11%) Query: 50 GSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDW 109 G+ Y + + D +A+KH+ ++ + E+ L ++ + LL + Sbjct: 54 GTTYKAL-LPDGSALAVKHLSTCKLGERE-------FRYEMNQLWELRHS--NLAPLLGF 103 Query: 110 FERPDSFVLILERPEPVQDLFDFITE-RGALQEELARSFFWQVLEAVRHCHN---CGVLH 165 + L+ + L + RG L + H+ +LH Sbjct: 104 CVVEEEKFLVYKYMSN-GTLHSLLDSNRGELDWSTRFRIGLGAARGLAWLHHGCRPPILH 162 Query: 166 RDIKDENILIDLNRGELKLIDFGSGALL------KDTVYTDFDGTRVYSPPEWIRYHRYH 219 ++I ILID + + ++ID G L+ + + T G Y PE+ Sbjct: 163 QNICSSVILIDEDF-DARIIDSGLARLMVPSDNNESSFMTGDLGEFGYVAPEY-STTMLA 220 Query: 220 GRSAAVWSLGILLYDMVCG 238 V+ LG++L ++ G Sbjct: 221 SLKGDVYGLGVVLLELATG 239 >3BYV-A nrPDB Length = 377 Score = 81.1 bits (199), Expect = 5e-16, Method: Composition-based stats. Identities = 39/172 (22%), Positives = 69/172 (40%), Gaps = 15/172 (8%) Query: 129 LFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG 188 L + +L QV+ + H+ G++H ++ +I++D RG + L F Sbjct: 193 LLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLD-QRGGVFLTGFE 251 Query: 189 SGALLKDTVYTDFDGTRVYSPPEW------IRYHR----YHGRSAAVWSLGILLYDMVCG 238 L++D +R + PPE I YHR S W+LG+++Y + C Sbjct: 252 --HLVRDGARVVSSVSRGFEPPELEARRATISYHRDRRTLMTFSFDAWALGLVIYWIWCA 309 Query: 239 DIPFEHDEEIIRGQVFFR--QRVSSECQHLIRWCLALRPSDRPTFEEIQNHP 288 D+P D + + FR + + + L+ L DR + P Sbjct: 310 DLPITKDAALGGSEWIFRSCKNIPQPVRALLEGFLRYPKEDRLLPLQAMETP 361 >6J6I-B nrPDB Length = 351 Score = 79.5 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 43/205 (20%), Positives = 72/205 (35%), Gaps = 27/205 (13%) Query: 53 YSGIRVS-DNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFE 111 Y R ++ IK +D I+ V ++VL ++S+ S ++LL Sbjct: 72 YKWYRGEIEDRSYMIKRFSEDEITGKRH--RVKEVYNDIVLSARMSN-HSNFLQLLGCCL 128 Query: 112 RPDSFVLILERPEPVQDLFDFITERGA---------LQEELARSFFWQVLEAVRHCHN-- 160 VL+ E E + +RG L + ++ AV + H Sbjct: 129 EFPFPVLVFEFAEHGA-----MNQRGGVIVNGEESLLPWSVRLKIGKEIANAVTYLHTAF 183 Query: 161 -CGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTD----FDGTRVYSPPEWIRY 215 ++HRD+K ++ +D N KL D L + GT Y P Sbjct: 184 PKIIIHRDVKPMHVFLDKNW-TAKLSDLSFSISLPEGKSRIEAEWVLGTFGYIDP-LYHK 241 Query: 216 HRYHGRSAAVWSLGILLYDMVCGDI 240 + V+S GI L ++ G Sbjct: 242 TCFVTEYTDVYSFGICLLVIITGKP 266 >4O1O-A nrPDB Length = 717 Score = 78.4 bits (192), Expect = 4e-15, Method: Composition-based stats. Identities = 58/284 (20%), Positives = 99/284 (34%), Gaps = 49/284 (17%) Query: 14 AAPCNDLHATKLAP-GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKD 72 LH GK K ++ +Y++ GG +Y G+ ++ VA+K Sbjct: 327 GEALKHLHRIWRPMIGKLKIFIDEEYKIADT-AEGG---IYLGLY--EDQEVAVKRFS-- 378 Query: 73 RISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPV--QDLF 130 TR EV L+ + V+ + L E + L Sbjct: 379 --------EGSTRGQQEVSCLQSSRAN-DNVVTFYGSESDGSCLHVCLALCEYTLQEHLA 429 Query: 131 DFITERGALQEEL-ARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGS 189 + + +E+ AR+ + +A+ H G H+D++ +NILID G L DF Sbjct: 430 NHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGT-FLADFDK 488 Query: 190 GALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLG-ILLYDMVCGDIPFEHDEEI 248 + P+ I+ + +LG ++LY + GDI FE + Sbjct: 489 SIKWAED-------------PQKIKR--------DLEALGLLVLYVVKKGDISFETLKNQ 527 Query: 249 IRGQVFFRQRVSSECQHLIRWCLAL--RPSDRPTFEEIQNHPWM 290 +V E + LI DR + + HP+ Sbjct: 528 SFEEVIQGSP-DEETRDLIHHLFHPGDNVEDRLS--SLLAHPFF 568 >4CI6-B nrPDB Length = 643 Score = 74.9 bits (183), Expect = 5e-14, Method: Composition-based stats. Identities = 52/297 (17%), Positives = 96/297 (32%), Gaps = 53/297 (17%) Query: 56 IRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLD--WFERP 113 I D + K +R G L + K + + + Sbjct: 63 IETKDKQRLVAKI---ERSIAEGHLFAELEAYKHIY---KTAGKHPNLANVHGMAVVPYG 116 Query: 114 DSFV--LILERPEP------VQDLFDFITERGALQEE---LARSFFWQVLEAVRHCHNCG 162 + + L+++ + ++ L D + E + ++L+ H G Sbjct: 117 NRYYYALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAG 176 Query: 163 VLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRS 222 ++H DIK N++ D GE +ID G + F T + PE + Sbjct: 177 IVHNDIKPGNVVFDRASGEPVVIDLGLHSR-SGEQPKGF--TESFKAPELGVGNLGASEK 233 Query: 223 AAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQ------------------ 264 + V+ +++ ++ G FE D EI Q R S Sbjct: 234 SDVF---LVVSTLLHGIEGFEKDPEIKPNQ-GLRFITSEPAHVMDENGYPIHRPGIAGVE 289 Query: 265 ----HLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHS-----LSPGPS 312 I L + RP E + H ++ D + +E+A+ L +SP P+ Sbjct: 290 TAYTRFITDILGVSADSRPDSNEARLHEFLSDGTIDEESAKQILKDTLTGEMSPLPT 346 >6BHC-A nrPDB Length = 438 Score = 74.1 bits (181), Expect = 8e-14, Method: Composition-based stats. Identities = 50/264 (18%), Positives = 89/264 (33%), Gaps = 44/264 (16%) Query: 64 VAIKHVE---KDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVI-RLLDWFE---RPDSF 116 A+K + K+ + L + + + + + V RLL W + + S Sbjct: 86 YAVKICKSKAKESQQYYHSLAVRQSLAVHFNIQQDCGHFLAEVPNRLLPWEDPSKKQRSH 145 Query: 117 VLILERPEPVQDLFDFIT-------ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIK 169 V+++ R P + DF+ + L E Q+ + H V H D++ Sbjct: 146 VVVITREVPCLTVADFVRDSLAQHGKSPDLYERQVCLLLLQLCSGLEHLKPYHVTHCDLR 205 Query: 170 DENILIDLNRGELKLIDFGSGALLKDTVY-TDFDGTRV-------------------YSP 209 EN+L+ + FG + Y T + Sbjct: 206 LENLLLVHYQPGGTAQGFGPAEPTPTSSYPTRLIVSNFSQAKQKSHLVDPEILRDQSRLA 265 Query: 210 PEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVF--------FRQRVSS 261 PE I +Y + + GIL+Y+M+ PF+ + E+ + FR S Sbjct: 266 PEIITATQY--KKCDEFQTGILIYEMLHLPNPFDENPELKEREYTRADLPRIPFRSPYSR 323 Query: 262 ECQHLIRWCLALRPSDRPTFEEIQ 285 Q L L PS+R + + Sbjct: 324 GLQQLASCLLNPNPSERILISDAK 347 >5CLR-A nrPDB Length = 451 Score = 73.8 bits (180), Expect = 9e-14, Method: Composition-based stats. Identities = 43/197 (21%), Positives = 73/197 (37%), Gaps = 26/197 (13%) Query: 53 YSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLD-WFE 111 + + D +K V+ D + T E L K+ RL+ +F Sbjct: 96 FKVYALDDGKTYFLKSVKIDA-------ESLTEFTNEKDTLSKLG-------RLVGTFFN 141 Query: 112 RPDSFVLILERPEPVQDLFDF---ITERGALQE-ELARSFFWQVLEAVRHCHNCGVLHRD 167 IL DL + + L+ V V+ H G++HRD Sbjct: 142 EQTQVHYILTTFIKGIDLSRYKNALPLNVNLKHFWEVLGIMISVCHQVKQFHELGLIHRD 201 Query: 168 IKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRS--AAV 225 +K NI++D + + L+DFGS + K+ + GT Y PE + S + + Sbjct: 202 LKPGNIMLDADM-QCHLVDFGSSSSDKEPKPASW-GTASYLAPELNAQEDFIAFSQVSDL 259 Query: 226 WSLGILLYDMVCGDIPF 242 ++L L ++ PF Sbjct: 260 FALAYSLDELF---NPF 273 >4OAU-C nrPDB Length = 699 Score = 72.6 bits (177), Expect = 2e-13, Method: Composition-based stats. Identities = 58/283 (20%), Positives = 94/283 (33%), Gaps = 46/283 (16%) Query: 14 AAPCNDLHATKLAP-GKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKD 72 A DLH GK K ++ +Y++ GG +Y G + VA+K Sbjct: 324 GAALKDLHRIYRPMIGKLKFFIDEKYKIADT-SEGG---IYLGFY--EKQEVAVKTF--- 374 Query: 73 RISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPE-PVQDLFD 131 R EV L+ S ++ + + E ++ D Sbjct: 375 -------CEGSPRAQREVSCLQSSREN-SHLVTFYGSESHRGHLFVCVTLCEQTLEACLD 426 Query: 132 FITERGALQEEL--ARSFFWQVLEAVRHCH-NCGVLHRDIKDENILIDLNRGELKLIDFG 188 EE AR+ + +AV+ H +CG H+D++ +NILID + L DF Sbjct: 427 VHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKA-AHLADFD 485 Query: 189 SGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLG-ILLYDMVCGDIPFEHDEE 247 P E + LG ++LY + G I FE D + Sbjct: 486 KSIKWAGD------------PQEV---------KRDLEDLGRLVLYVVKKGSISFE-DLK 523 Query: 248 IIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWM 290 + + E + LI R ++ HP+ Sbjct: 524 AQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFF 566 >5DMZ-A nrPDB Length = 365 Score = 72.2 bits (176), Expect = 3e-13, Method: Composition-based stats. Identities = 42/224 (18%), Positives = 76/224 (33%), Gaps = 36/224 (16%) Query: 40 VGPLLGSGGFGSVYSGI-----RVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLK 94 V LLG G F VY + +K + N + L++ Sbjct: 69 VHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKV---------QKPANPWEFYIGTQLME 119 Query: 95 KVSSGFSG-VIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEE-----LARSFF 148 ++ ++ + VL+ E L + I E+ L SF Sbjct: 120 RLKPSMQHMFMKFYSAHLFQNGSVLVGELYS-YGTLLNAINLYKNTPEKVMPQGLVISFA 178 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGE----------LKLIDFGSGALL----K 194 ++L + H+C ++H DIK +N ++ E L LID G + K Sbjct: 179 MRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPK 238 Query: 195 DTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCG 238 T++T T + E + ++ + + +Y M+ G Sbjct: 239 GTIFTAKCETSGFQCVEMLSNKPWN-YQIDYFGVAATVYCMLFG 281 >3DZO-A nrPDB Length = 413 Score = 71.1 bits (173), Expect = 6e-13, Method: Composition-based stats. Identities = 35/171 (20%), Positives = 69/171 (40%), Gaps = 14/171 (8%) Query: 129 LFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG 188 L + +L QV+ + H+ G++H ++ +I++D RG + L F Sbjct: 198 LLSHSSTHKSLVHHARLQLTLQVIRLLASLHHYGLVHTYLRPVDIVLD-QRGGVFLTGFE 256 Query: 189 SGALLKDTVYTDFDGTRVYSPPE-----WIRYHRYH----GRSAAVWSLGILLYDMVCGD 239 L++D R ++PPE + + ++H + W+LG+ +Y + C D Sbjct: 257 --HLVRDGASAVSPIGRGFAPPETTAERMLPFGQHHPTLMTFAFDTWTLGLAIYWIWCAD 314 Query: 240 IPFEHDEEIIRGQVFFR--QRVSSECQHLIRWCLALRPSDRPTFEEIQNHP 288 +P D + + FR + + + L+ L DR + P Sbjct: 315 LPNTDDAALGGSEWIFRSCKNIPQPVRALLEGFLRYPKEDRLLPLQAMETP 365 >6G4J-A nrPDB Length = 315 Score = 69.9 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 35/163 (21%), Positives = 62/163 (38%), Gaps = 29/163 (17%) Query: 36 SQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 + Y + LG G G VY SD VA+K + + EV +LK Sbjct: 26 NTYTLRKQLGKGANGIVYLA-ETSDG-HVALKV-----------SDDSLSITSEVNVLKS 72 Query: 96 VSSGFSGVIRLLDWFERPDSFVL----------ILERPEPVQDLFDFITERGALQEELAR 145 S S + + F D + +E + L +++++GA E Sbjct: 73 FSKAQS--VTMGPSFFDTDDAYIPSANTKVSFYAMEYIKGP-LLLKYVSDKGA---EWIP 126 Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG 188 Q+L ++ H G + D+K +N+++ ++ ID G Sbjct: 127 VLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPPARIRCIDVG 169 >6EAS-A nrPDB Length = 308 Score = 69.9 bits (170), Expect = 1e-12, Method: Composition-based stats. Identities = 46/270 (17%), Positives = 89/270 (32%), Gaps = 48/270 (17%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 ++GS +Y G +S + +A+ DW + N ++ ++ L KVS Sbjct: 47 IIGSTSTCMLYKGT-LSSGVEIAVASSLVTSAKDWSK-ENESQYRKKITNLSKVSH--KN 102 Query: 103 VIRLLDWFERPDSF--VLILERPEPVQDLFDFI--TERGALQEELARSFFWQVLEAVRHC 158 + LL + E F V++ E P LF+ + E L + + H Sbjct: 103 FMNLLGYCEEEHPFTRVMVFEYA-PNGTLFEHLHVREAEKLDWMARLRISMGIAYCLEHM 161 Query: 159 HNCGV--LHRDIKDENILIDLNRGELKLID---FGSGALLKDTVYTDFDGTRVYSPPEWI 213 H R+ + + + K+ D + T + + E I Sbjct: 162 HQLQTPAALRNFDSTTVYLT-DDFAAKVSDLEFWNDAKGHNSTTNNELAFSPDM---EDI 217 Query: 214 RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQV-------------------F 254 G++L +++ G +P D+ + V F Sbjct: 218 VRK-----------YGMVLLEILTGRVPSSEDDGPLENWVSRYFEGGMRLEELIDPSIGF 266 Query: 255 FRQRVSSECQHLIRWCLALRPSDRPTFEEI 284 F + + ++R C+ P RP +E+ Sbjct: 267 FPEDTARALCEVVRSCIDRDPKKRPQMKEV 296 >2W1Z-A nrPDB Length = 368 Score = 64.9 bits (157), Expect = 4e-11, Method: Composition-based stats. Identities = 36/162 (22%), Positives = 65/162 (40%), Gaps = 14/162 (8%) Query: 129 LFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFG 188 L + +L Q++ + G++H D + NIL+D RG + L F Sbjct: 178 LLSHSSTHKSLVHHARLQLTLQLIRLAASLQHYGLVHADFQVRNILLD-QRGGVFLTGFE 236 Query: 189 SGALLKDTVYTDFDGTRVYSPPE-----WIRYHRYH----GRSAAVWSLGILLYDMVCGD 239 L++D R ++PPE + Y ++H W+LG+ +Y + C D Sbjct: 237 --HLVRDGASAVSPIGRGFAPPETTAERMLPYRQHHPTLMTFPFDTWTLGLAIYWIWCAD 294 Query: 240 IPFEHDEEIIRGQVFFR--QRVSSECQHLIRWCLALRPSDRP 279 +P D E+ + +R + + + L+ L DR Sbjct: 295 LPNTEDAELGGIEWIYRRCKNIPQPVRALLEGFLRYSKEDRL 336 >6EWX-A nrPDB Length = 484 Score = 63.0 bits (152), Expect = 2e-10, Method: Composition-based stats. Identities = 31/197 (15%), Positives = 57/197 (28%), Gaps = 55/197 (27%) Query: 141 EELARSFFWQVLEAVRHCHNCGVLHRDIKDENILI------------------------- 175 E Q+ + H G++HRD+ EN+L+ Sbjct: 209 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLLVHCNPQSSPGPSANPSVPTTTSRCP 268 Query: 176 ---------------DLNRGELKLIDFGSGALLKDTVYT-DFDGTRVYSPPEWIRYHRYH 219 + + L + +F ++ PE + +Y Sbjct: 269 SAAPAATTACQGGPGEKHLPRLIISNFLKAKQKPGGTTNLQQKKSQARLAPEIVSASQY- 327 Query: 220 GRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR----------VSSECQHLIRW 269 R + GIL+Y+++ PFE ++ + +R+ S Q L Sbjct: 328 -RKFDEFQTGILIYELLHQPNPFEVRAQLR--ERDYRREDLPPLPTLSLYSPGLQQLAHL 384 Query: 270 CLALRPSDRPTFEEIQN 286 L P R E + Sbjct: 385 LLEADPIKRIRIGEAKR 401 >6M7Z-A nrPDB Length = 319 Score = 59.5 bits (143), Expect = 2e-09, Method: Composition-based stats. Identities = 34/175 (19%), Positives = 63/175 (36%), Gaps = 34/175 (19%) Query: 140 QEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT 199 + ++ A++ HN G+LHR I+ N L G + L + A + Sbjct: 142 SHPDVQVLAANMVAALKSLHNLGLLHRSIEL-NSFSVLPDGTVVLGGLDTAAPIGTE--- 197 Query: 200 DFDGTRVYS-------PPEW--------IRYHRYHGRSAAVWSLGIL---LYDMV-CGDI 240 TR++ PE H + V+SLG+ L ++ G++ Sbjct: 198 ----TRLWVGFFGQETAPEIDRNFLADLALTQGRHTVKSDVYSLGVAFRNLVQLLGNGNL 253 Query: 241 PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLL 295 E + + + ++S + + P +RPT EEI P + + Sbjct: 254 GPEDRGAVRQDHLELLDKLS-------QKMIEEEPGNRPTIEEIMKDPLFEGLNF 301 >2JII-A nrPDB Length = 352 Score = 58.0 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 36/211 (17%), Positives = 82/211 (38%), Gaps = 23/211 (10%) Query: 70 EKDRISDWGELPNGTRVPMEVVLLKKV-SSGFSGVIRLLDWFERPDSFVLILERPEPVQD 128 + R+ + P++V KK+ S+ + + + D + ++ P + Sbjct: 85 KDGRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLAIPTCMGFGVHQDKYRFLV-LPSLGRS 143 Query: 129 LFDFIT--ERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILID-LNRGELKLI 185 L + + L E ++L+A+ H +H ++ ENI +D ++ ++ L Sbjct: 144 LQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDQSQVTLA 203 Query: 186 DFGSG-ALLKDTVYTDFD-GTRVYSPP-----EWIRYHRYHG----RSAAVWSLGILLYD 234 +G + + G+R P E+I + G R + + SLG + Sbjct: 204 GYGFAFRYCPSGKHVAYVEGSR---SPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLK 260 Query: 235 MVCGDIPF----EHDEEIIRGQVFFRQRVSS 261 + G +P+ + E+I++ + F + Sbjct: 261 WLYGFLPWTNCLPNTEDIMKQKQKFVDKPGP 291 >5GZA-A nrPDB Length = 290 Score = 53.7 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 42/289 (14%), Positives = 80/289 (27%), Gaps = 57/289 (19%) Query: 26 APGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTR 85 +P + + S + L+G G VY VA+ + D+ +D Sbjct: 15 SPWLKCPEIRSGVRRVKLIGQGAVKKVYLSEWQ--GQKVALSVLSSDQYADD-------- 64 Query: 86 VPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELAR 145 + +L+ + S V+ L+ E V + E P+ + T + Sbjct: 65 FLHGLSMLRALQSSH--VVTLVGVCEEDA--VFVTEY-HPLGSVLTLDTTLAQERYRWRN 119 Query: 146 SFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLK----------- 194 S+ ++ A+ + LH ++ D N L F + ++ Sbjct: 120 SWHTRLQLAIDYVAFLAYLHSSPAGIRVMCDSNDLHKTLSQFLLASDMRLLANDLDALPE 179 Query: 195 --DTVYTDFDG----TRVYSPPEWI-----------RYHRYHGRSAAVWSLGILLYDMVC 237 G T + PE + + +W Sbjct: 180 VEKGGLGVKCGHHELTGDFVAPEQLWPYGEDFSFSDEAMPGYDEKTDIW----------- 228 Query: 238 GDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQN 286 IP + G V + + C RPT E+ + Sbjct: 229 -KIP--DVTRFLLGDVLGGDVIHFHLFQIYSECKRKEAHMRPTAREVLS 274 >5GZ9-A nrPDB Length = 305 Score = 53.0 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 40/280 (14%), Positives = 82/280 (29%), Gaps = 52/280 (18%) Query: 32 EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVV 91 E L ++ + +G G V+ VA+ S L + Sbjct: 30 EELRTEVRQLKRVGEGAVKRVFLSEWKE--HKVAL--------SRLTRLEMKEDFLHGLQ 79 Query: 92 LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI---TERGALQEELARSFF 148 +LK + S V+ L+ + E + + + +L + + + + Sbjct: 80 MLKSLQSEH--VVTLVGYCEEDGTILTEYHPLGSLSNLEETLQLSKYQDVNTWQHRLQLA 137 Query: 149 WQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGA--------LLKDTVYTD 200 + + + + H+ + R + D N L L +F A + D+ Sbjct: 138 MEYVSIINYLHHSPLGTRVMCDSNDLPKTLSQYLLTSNFSIVANDLDALPLVDHDSGVLI 197 Query: 201 FDGTRV----YSPPEWI-----------RYHRYHGRSAAVWSLGILLYDMVCGDIPFEHD 245 G R + PE + + +W IP Sbjct: 198 KCGHRELHGDFVAPEQLWPYGEDTPFQDDLMPSYNEKVDIW------------KIP--DV 243 Query: 246 EEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQ 285 + G V V + + C + P++RPT + + Sbjct: 244 SSFLLGHVEGSDMVRFHLFDIHKACKSQIPAERPTAQNVL 283 >4CZY-B nrPDB Length = 429 Score = 50.6 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 22/144 (15%), Positives = 54/144 (37%), Gaps = 22/144 (15%) Query: 53 YSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFER 112 Y + A++ +E R+++ + N T+ +++ + ++ + + F Sbjct: 61 YKAQNNKNGRHFALRRIEGYRLTNEKAILNVTKEWKKII--------NANIVTVHEAFTT 112 Query: 113 P----DSFVLILERPEPVQDLFDF----------ITERGALQEELARSFFWQVLEAVRHC 158 S + + + + L+D + + E L S+ Q+ A+ Sbjct: 113 EFFGDSSLIFVYDFHPLSETLYDHHFPPNNSHNRLRNTNKIPENLLWSYVCQIANALLAI 172 Query: 159 HNCGVLHRDIKDENILIDLNRGEL 182 HN + R ++ I+ + NR L Sbjct: 173 HNAKLAARCLELSKIIWENNRIRL 196 >3ENH-A nrPDB Length = 540 Score = 50.6 bits (120), Expect = 8e-07, Method: Composition-based stats. Identities = 32/154 (20%), Positives = 50/154 (32%), Gaps = 18/154 (11%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIK-HVEKD-RISDWGELPNGTRVPMEVVLLKKVSSGF 100 L+G G + + V IK V+K R E +R E L V Sbjct: 343 LIGKGAEADIK--RDSYLDFDVIIKERVKKGYRDERLDENIRKSRTAREARYLALVKDFG 400 Query: 101 SGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHN 160 + D I+ + D I + +++ E V H Sbjct: 401 IPAPYIFDVDLDNKR---IMMSYINGKLAKDVIEDN--------LDIAYKIGEIVGKLHK 449 Query: 161 CGVLHRDIKDENILIDLNRGELKLIDFGSGALLK 194 V+H D+ N + D + L +IDFG G + Sbjct: 450 NDVIHNDLTTSNFIFDKD---LYIIDFGLGKISN 480 >4CYJ-A nrPDB Length = 438 Score = 50.3 bits (119), Expect = 1e-06, Method: Composition-based stats. Identities = 30/246 (12%), Positives = 73/246 (29%), Gaps = 55/246 (22%) Query: 49 FGS---VYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIR 105 FG VY + A++ +E R+++ + N + ++ ++ Sbjct: 65 FGYPSWVYKAQNSRNGRHYALRRLEGYRLTNEKAILNVMKDWKKIKNAS--------IVT 116 Query: 106 LLDWFER----PDSFVLILERPEPVQDLFDFITER---------GALQEELARSFFWQVL 152 + + F S + + + L + + A+ E + Q+ Sbjct: 117 IHEVFTTREFGDSSLIFAYDFHPLSKTLQEHHFQPIHGNRYRPPPAVPENTIWGYICQIA 176 Query: 153 EAVRHCHNCGVLHRDIKDENILIDL----NRGELKLID---FGSGALLKDTVYTDFDGTR 205 A++ H+ + R ++ I++ ++D FG + Sbjct: 177 NALKTIHSNRLAARCLEPSKIILTDINRIRLSACAILDVVQFGMNSRS------------ 224 Query: 206 VYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQH 265 + + G L+ + G +P H I + S+ + Sbjct: 225 ------VVELQQEDFVK-----FGKLILSLATGTLP-AHLNNIPAALETLGNKYSANLKS 272 Query: 266 LIRWCL 271 + W L Sbjct: 273 AVNWLL 278 >6G38-A nrPDB Length = 357 Score = 49.5 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 35/179 (19%), Positives = 58/179 (32%), Gaps = 44/179 (24%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHV--------EKDRISDWGELPNGTRV 86 + Q +G G FG V+ I +D+ PVAIK + + E+ + Sbjct: 40 TEKLQRCEKIGEGVFGEVFQTI--ADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIII 97 Query: 87 PMEVVLLK----------------KVSSGFSGVIRLLDW---------------FERPDS 115 E+ LL G + L W F + D Sbjct: 98 SKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQ 157 Query: 116 FVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH-NCGVLHRDIKDENI 173 ++LE DL T+ +L A+S Q+ ++ + HRD+ N+ Sbjct: 158 LFIVLEFEFGGIDLEQMRTKLSSL--ATAKSILHQLTASLAVAEASLRFEHRDLHWGNV 214 >4AZV-A nrPDB Length = 569 Score = 49.5 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 27/116 (23%), Positives = 50/116 (43%), Gaps = 6/116 (5%) Query: 74 ISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI 133 ++ N + E+ L + +GF +L E S L++E+ P + L D + Sbjct: 276 LTAEESQRNKYELHNEIKFLTQPPAGFD-APAVLAHGENAQSGWLVMEKL-PGRLLSDML 333 Query: 134 TERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGS 189 A +E +L ++ G H D++ N+++D + +LIDFGS Sbjct: 334 ---AAGEEIDREKILGSLLRSLAALEKQGFWHDDVRPWNVMVDARQ-HARLIDFGS 385 >4AZW-A nrPDB Length = 471 Score = 49.5 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 27/116 (23%), Positives = 50/116 (43%), Gaps = 6/116 (5%) Query: 74 ISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI 133 ++ N + E+ L + +GF +L E S L++E+ P + L D + Sbjct: 276 LTAEESQRNKHELHNEIKFLTQPPAGFD-APAVLAHGENAQSGWLVMEKL-PGRLLSDML 333 Query: 134 TERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGS 189 A +E +L ++ G H D++ N+++D + +LIDFGS Sbjct: 334 ---AAGEEIDREKILGSLLRSLAALEKKGFWHDDVRPWNVMVDARQ-HARLIDFGS 385 >4WWA-A nrPDB Length = 261 Score = 47.2 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 28/150 (18%), Positives = 49/150 (32%), Gaps = 11/150 (7%) Query: 53 YSGIRVSDNLPVAIKHV--EKDRISDWGELPNGTRVPMEVVLLKKV-SSGFSGVIRLLDW 109 Y + IK+ ++ R + R E LL K+ V +L+ Sbjct: 38 YLPRAKDSHQKYIIKYRPPKRYRHPQIDQALTKHRTLNESRLLAKLYLIPGLCVPQLIAC 97 Query: 110 FERPDSFVLIL---ERPEPVQ--DLFDFI-TERGALQEELARSFFWQVLEAVRHCHNCGV 163 L + P +L +F+ +L + +V + H Sbjct: 98 DPYNGFIWLEFLGEDLPGGHGFSNLKNFLWMHDQDPYSDLVATTLRKVGRQIGLLHWNDY 157 Query: 164 LHRDIKDENILIDLNRGE--LKLIDFGSGA 191 H D+ NI++ + LIDFG G+ Sbjct: 158 CHGDLTSSNIVLVRDGARWTPHLIDFGLGS 187 >4BWP-A nrPDB Length = 448 Score = 46.4 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 34/267 (12%), Positives = 78/267 (29%), Gaps = 58/267 (21%) Query: 53 YSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFER 112 Y + ++ + G T+ V + KK+ V++L + F Sbjct: 67 YRATHNTTGYKYCLRRI-------HGFRLQSTKCMTLVEMWKKLQHT--NVVQLREVFTT 117 Query: 113 P----DSFVLILERPEPVQDL------------------------FDFITERGA------ 138 +S VL+ + Q L F + Sbjct: 118 KAFGDNSLVLVYDYHPGSQTLLAKYFTPAPETNGYTDPFQGEARPFSHKSNMQRTSNGPL 177 Query: 139 LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVY 198 L E S Q+ ++ H+ G+ + + I++ R F S + T + Sbjct: 178 LPEATIWSIIMQLTAGLKAIHHAGLACKVLDPTKIIVTGKRVR-----FSSCCISDITQF 232 Query: 199 TDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR 258 + H+ + +LG L+ + C + + + + Sbjct: 233 DPNASNP--LA--LVNMHQ----QDDLTALGRLVLALACRCLQSVQRDNVQSSIDMVTRN 284 Query: 259 VSSECQHLIRWCLALRPSDRPTFEEIQ 285 S++ ++ I + +R + ++ Sbjct: 285 YSTDLRNFIVYLFTTN--NRRSVTDLM 309 >5VE6-A nrPDB Length = 492 Score = 44.9 bits (105), Expect = 4e-05, Method: Composition-based stats. Identities = 20/89 (22%), Positives = 32/89 (35%), Gaps = 14/89 (15%) Query: 208 SPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQR--------- 258 PE + +Y R + GIL+Y+++ PFE ++ + +RQ Sbjct: 325 LAPEIVSASQY--RKFDEFQTGILIYELLHQPNPFEVRAQLR--ERDYRQEDLPPLPALS 380 Query: 259 -VSSECQHLIRWCLALRPSDRPTFEEIQN 286 S Q L L P R E + Sbjct: 381 LYSPGLQQLAHLLLEADPIKRIRIGEAKR 409 Score = 44.5 bits (104), Expect = 5e-05, Method: Composition-based stats. Identities = 10/35 (28%), Positives = 17/35 (48%) Query: 141 EELARSFFWQVLEAVRHCHNCGVLHRDIKDENILI 175 E Q+ + H G++HRD+ EN+L+ Sbjct: 207 ERRVCFLLLQLCNGLEHLKEHGIIHRDLCLENLLL 241 >6R5K-O nrPDB Length = 689 Score = 44.9 bits (105), Expect = 5e-05, Method: Composition-based stats. Identities = 21/162 (12%), Positives = 53/162 (32%), Gaps = 19/162 (11%) Query: 53 YSGIRVSDNLPVAIKHV-EKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFE 111 + D +K + D+ + ++ ++ ++ + +I+ D F+ Sbjct: 311 FKVFSNYDGKAYVLKRLPNIDKSMNPNKISKIYQIWSKIN--------CTNLIKFRDIFQ 362 Query: 112 RPD----SFVLILERPEPVQDLFDFI---TERGALQEELARSFFWQVLEAVRHCHNCGV- 163 S L+ + L+D+ + + + Q+ + H+ + Sbjct: 363 TTKFGDLSICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLS 422 Query: 164 LHRDIKDENILIDLNRGELKL--IDFGSGALLKDTVYTDFDG 203 + + +LI + G +KL +F DT G Sbjct: 423 IGNTLNWRKVLITGDPGRIKLSHCNFMDLLFNDDTDTVVSSG 464 >4XR7-L nrPDB Length = 465 Score = 43.3 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 21/162 (12%), Positives = 53/162 (32%), Gaps = 19/162 (11%) Query: 53 YSGIRVSDNLPVAIKHV-EKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFE 111 + D +K + D+ + ++ ++ ++ + +I+ D F+ Sbjct: 87 FKVFSNYDGKAYVLKRLPNIDKSMNPNKISKIYQIWSKIN--------CTNLIKFRDIFQ 138 Query: 112 RPD----SFVLILERPEPVQDLFDFI---TERGALQEELARSFFWQVLEAVRHCHNCGV- 163 S L+ + L+D+ + + + Q+ + H+ + Sbjct: 139 TTKFGDLSICLVFDYYPNSLSLYDYHFVNFPKFPITNNYLWIYLVQLTNVINSIHSQNLS 198 Query: 164 LHRDIKDENILIDLNRGELKL--IDFGSGALLKDTVYTDFDG 203 + + +LI + G +KL +F DT G Sbjct: 199 IGNTLNWRKVLITGDPGRIKLSHCNFMDLLFNDDTDTVVSSG 240 >3Q60-A nrPDB Length = 371 Score = 39.1 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 34/170 (20%), Positives = 56/170 (32%), Gaps = 35/170 (20%) Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRV 206 Q++ + + G++H +N+ I + G L L D AL K GTR Sbjct: 199 LTAQLIRLAANLQSKGLVHGHFTPDNLFIMPD-GRLMLGD--VSALWK-------VGTRG 248 Query: 207 --------YSPPEWIRYHRYH-GRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQ 257 Y+P E++ + W LG+ +Y + C +PF I+G Sbjct: 249 PASSVPVTYAPREFLNASTATFTHALNAWQLGLSIYRVWCLFLPFGLVTPGIKGSWKRPS 308 Query: 258 ---------------RVSSECQHLIRWCLALRPSDRPTFEEIQNHP-WMQ 291 + + LI L R E P ++Q Sbjct: 309 LRVPGTDSLAFGSCTPLPDFVKTLIGRFLNFDRRRRLLPLEAMETPEFLQ 358 >5I35-A nrPDB Length = 393 Score = 37.9 bits (87), Expect = 0.005, Method: Composition-based stats. Identities = 27/182 (14%), Positives = 54/182 (29%), Gaps = 32/182 (17%) Query: 50 GSVYSGIRVSDNLPVAIKH-------------------VEKDRISDWGELPNGT--RVPM 88 G V+ + VA+K + + G P + Sbjct: 88 GQVHLAR-MKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRR 146 Query: 89 EVVLLKKVSSGFSGVIRLLDWFERPDSFV---LILERPEPVQDLFDF-----ITERGALQ 140 E+ L + + D + F ++ E P + + + L Sbjct: 147 ELALECDYQREAACARKFRDLLKGHPFFYVPEIVDELCSPHVLTTELVSGFPLDQAEGLS 206 Query: 141 EELARSFFWQVL-EAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYT 199 +E+ + +L +R + D N D + ++ L+DFG+ D +T Sbjct: 207 QEIRNEICYNILVLCLRELFEFHFMQTDPNWSNFFYDPQQHKVALLDFGATREY-DRSFT 265 Query: 200 DF 201 D Sbjct: 266 DL 267 >4BVU-A nrPDB Length = 211 Score = 36.8 bits (84), Expect = 0.014, Method: Composition-based stats. Identities = 24/148 (16%), Positives = 47/148 (31%), Gaps = 18/148 (12%) Query: 40 VGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSG 99 +G L+G G ++ + S L +K + E L Sbjct: 44 LGKLIGQGSTAEIFEDVNDSSALY------KKYDLIGNQYNEILEMAWQESELFNAFYGD 97 Query: 100 FSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCH 159 + V+ + L + R P L D + + + + + + + + Sbjct: 98 EASVV-----IQYGGDVYLRMLRV-PGTPLSDI--DTADIPDNIESLYLQLICK----LN 145 Query: 160 NCGVLHRDIKDENILIDLNRGELKLIDF 187 ++H D+ N+L D L IDF Sbjct: 146 ELSIIHYDLNTGNMLYDKESESLFPIDF 173 >5YK0-A nrPDB Length = 452 Score = 36.0 bits (82), Expect = 0.022, Method: Composition-based stats. Identities = 36/180 (20%), Positives = 62/180 (34%), Gaps = 41/180 (22%) Query: 50 GSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFS--GVI--- 104 G V+ I SD VA+K + +D + + V +LK++S G GV+ Sbjct: 146 GQVHKAIW-SDGREVAVKI--QYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDEL 202 Query: 105 ------------------RLLDWFERPDSF-----------VLILERPEPVQDLFDFITE 135 + F V+I E E V + + I Sbjct: 203 VERTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGV-PMAEIIRH 261 Query: 136 RGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKD 195 Q +L + ++ G++H D N ++ L G + +IDFG+ A + Sbjct: 262 GTTEQRDLIGTLLAELT--FDAPRRLGLMHGDAHPGNFML-LPDGRMGIIDFGAVAPMPG 318 >6FAI-l nrPDB Length = 425 Score = 35.6 bits (81), Expect = 0.026, Method: Composition-based stats. Identities = 28/175 (16%), Positives = 55/175 (31%), Gaps = 34/175 (19%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKH-----------------VEKDRISDW 77 ++ Y VG +G G +Y + N V +K ++K Sbjct: 92 DTVYSVGNTIGVGKESDIYKVSDKNGNPRV-MKIHRLGRTSFHSVRNNRDYLKKSNQGAN 150 Query: 78 GELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERG 137 + E + + S V D ++++E E + + Sbjct: 151 WMHLSRLAANKEYQFMSMLYSKGFKVPEPFD----NSRHIVVMELIEGYP--MRRLRKHK 204 Query: 138 ALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILI-----DLNRGELKLIDF 187 + + ++ + N G++H D + NI+I D N +IDF Sbjct: 205 NIP-----KLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDENDCGFVVIDF 254 >1TQM-A nrPDB Length = 282 Score = 35.2 bits (80), Expect = 0.032, Method: Composition-based stats. Identities = 28/161 (17%), Positives = 53/161 (32%), Gaps = 31/161 (19%) Query: 40 VGPLLGSGG-----------FGSVYSGIRVSDNLPVAIKHVEKDRISDWGE--LPNGTRV 86 +G L+G G FG + K V++ R + Sbjct: 94 IGKLMGEGKESAVFNCYSEKFGECVVKFHKVGHTSF--KKVKEKRDYGDLHFSVLAIRSA 151 Query: 87 PMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARS 146 E L+K+ V ++ W +L ++L+ E + Sbjct: 152 RNEFRALQKLQGLA--VPKVYAWEGNA-----VLMELIDAKELYRVRVEN----PDEVLD 200 Query: 147 FFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDF 187 +LE V ++ G++H D+ N+L+ + +IDF Sbjct: 201 M---ILEEVAKFYHRGIVHGDLSQYNVLVSEEG--IWIIDF 236 >6G18-v nrPDB Length = 552 Score = 34.9 bits (79), Expect = 0.042, Method: Composition-based stats. Identities = 22/147 (14%), Positives = 46/147 (31%), Gaps = 23/147 (15%) Query: 41 GPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGF 100 LG F + + K R + + E +K + Sbjct: 124 LHRLGRTSF------RNLKNKRDY-----HKHRHNVSWLYLSRLSAMKEFAYMKALYERK 172 Query: 101 SGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHN 160 V + +D+ + +++E E A + A + N Sbjct: 173 FPVPKPIDY----NRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVK-------LAN 221 Query: 161 CGVLHRDIKDENILIDLNRGELKLIDF 187 G++H D + N+++D + + +IDF Sbjct: 222 HGLIHGDFNEFNLILDESD-HITMIDF 247 >6DFL-A nrPDB Length = 259 Score = 34.9 bits (79), Expect = 0.044, Method: Composition-based stats. Identities = 32/196 (16%), Positives = 61/196 (31%), Gaps = 14/196 (7%) Query: 18 NDLHATKLAPGKEKEPLESQYQVG-PLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISD 76 + A + GK LE + + + G G F ++ GI + + K+ ++ Sbjct: 17 DPFEAVEALQGKVYRELEGRRTLRTEVDGRGYFVKIHRGIGWGE--------IAKNLLTA 68 Query: 77 WGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERP--DSFVLILERPEPVQDL--FDF 132 + + + L + + + P ++ E P DL F Sbjct: 69 KLPVLGARQEWQAIRRLHEAGVATMTAVAYGERGSDPARQHSFIVTEELAPTVDLEVFSQ 128 Query: 133 ITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGAL 192 L R+ V V H GV HRD + L+ ++ + DF + Sbjct: 129 DWRERPPPPRLKRALVEAVARMVGDMHRAGVNHRDCYICHFLLHTDK-PVSADDFRLSVI 187 Query: 193 LKDTVYTDFDGTRVYS 208 T + + Sbjct: 188 DLHRAQTRDATPKRWR 203 >6FDN-A nrPDB Length = 320 Score = 33.7 bits (76), Expect = 0.10, Method: Composition-based stats. Identities = 22/147 (14%), Positives = 46/147 (31%), Gaps = 23/147 (15%) Query: 41 GPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGF 100 LG F + + K R + + E +K + Sbjct: 124 LHRLGRTSF------RNLKNKRDY-----HKHRHNVSWLYLSRLSAMKEFAYMKALYERK 172 Query: 101 SGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHN 160 V + +D+ + +++E E A + A + N Sbjct: 173 FPVPKPIDY----NRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVK-------LAN 221 Query: 161 CGVLHRDIKDENILIDLNRGELKLIDF 187 G++H D + N+++D + + +IDF Sbjct: 222 HGLIHGDFNEFNLILDESD-HITMIDF 247 >4H05-A nrPDB Length = 273 Score = 32.2 bits (72), Expect = 0.29, Method: Composition-based stats. Identities = 19/67 (28%), Positives = 26/67 (38%), Gaps = 4/67 (5%) Query: 123 PEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGEL 182 E DL D ER E + + A V H D+ +N+L+D E+ Sbjct: 149 AEGSVDLEDLDEERKGWSGERLLAELERTRPADEDL---AVCHGDLCPDNVLLDPRTCEV 205 Query: 183 K-LIDFG 188 LID G Sbjct: 206 TGLIDVG 212 >6EF6-A nrPDB Length = 354 Score = 31.0 bits (69), Expect = 0.70, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 19/35 (54%), Gaps = 2/35 (5%) Query: 160 NCGVLHRDIKDENILIDLN--RGELKLIDFGSGAL 192 G++H D++ N+L+D + + + +IDF Sbjct: 224 RYGLIHADLRLANLLVDSSTPQRTITVIDFDDCGF 258 >4ESA-B nrPDB Length = 146 Score = 30.6 bits (68), Expect = 0.80, Method: Composition-based stats. Identities = 15/85 (17%), Positives = 28/85 (32%), Gaps = 10/85 (11%) Query: 47 GGFGSVYSGIRVSDNLPVA---IKHVEKDRISDWGELPNGTRVPMEVVLLKKVS-SGFSG 102 G FG++Y+ + N VA IK + + N + E+ +L Sbjct: 43 GSFGNLYNAEAIIGNQKVAAHGIKVL-HGLDRAVKNMDNIKEIYAELSILHSEKLHVDPD 101 Query: 103 VIRLLDWFERPDSFVLILERPEPVQ 127 +LL D +++ Sbjct: 102 NFKLL-----ADCLTIVVAAKMGSG 121 >1DL2-A nrPDB Length = 511 Score = 30.2 bits (67), Expect = 1.0, Method: Composition-based stats. Identities = 9/47 (19%), Positives = 19/47 (40%), Gaps = 2/47 (4%) Query: 185 IDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVW--SLG 229 D+ + DT Y + + PE + ++ + + W S+G Sbjct: 335 SDWDLAKGITDTCYQMYKQSSSGLAPEIVVFNDGNIKQDGWWRSSVG 381 >4GYG-A nrPDB Length = 397 Score = 29.5 bits (65), Expect = 1.8, Method: Composition-based stats. Identities = 25/161 (15%), Positives = 44/161 (27%), Gaps = 28/161 (17%) Query: 35 ESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNG----------- 83 + Y VG +G G + V +K RIS N Sbjct: 94 KDVYSVGSRIGVGKESDIMIVADEKGKQKV-LKIHRLGRISFRTVKANRDYLRNRSTGSW 152 Query: 84 -----TRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGA 138 E +K + V + +++ L D + R Sbjct: 153 MYLSRLAAIKEFAFMKALYEEGFPVPEPIA----QSRHTIVM-------SLVDALPMRQV 201 Query: 139 LQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNR 179 S + ++ + G++H D + NILI + Sbjct: 202 SSVPDPASLYADLIALILRLAKHGLIHGDFNEFNILIREEK 242 >5ITI-A nrPDB Length = 243 Score = 29.1 bits (64), Expect = 2.9, Method: Composition-based stats. Identities = 8/36 (22%), Positives = 17/36 (47%), Gaps = 3/36 (8%) Query: 279 PTFEEIQNHPW---MQDVLLPQETAEIHLHSLSPGP 311 T E+ + HPW + L ++ ++I + + P Sbjct: 152 LTIEQARQHPWRHVLSQCLGREDLSQIDIQPIDLEP 187 >3E1K-A nrPDB Length = 465 Score = 28.3 bits (62), Expect = 4.2, Method: Composition-based stats. Identities = 10/60 (16%), Positives = 20/60 (33%), Gaps = 1/60 (1%) Query: 58 VSDNLPVAIK-HVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSF 116 +N AIK + + + MEV L+ +S ++R+ + Sbjct: 335 TDNNGAAAIKDKEKVTKSPSPSTGTSEEEQTMEVFHLRNYNSVVGNILRIYESIADYHFL 394 >5OQL-d nrPDB Length = 446 Score = 28.3 bits (62), Expect = 4.9, Method: Composition-based stats. Identities = 8/45 (17%), Positives = 14/45 (31%) Query: 51 SVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKK 95 V + AIK E++ + + E +L K Sbjct: 400 VVKKATEIKREELAAIKRREENERKHSNKKYEKRKSEREKAVLVK 444 >1Z82-A nrPDB Length = 335 Score = 27.5 bits (60), Expect = 6.7, Method: Composition-based stats. Identities = 10/61 (16%), Positives = 27/61 (44%), Gaps = 1/61 (1%) Query: 43 LLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSG 102 +LG+G +G+V++ + + V I + I D + + + E + + ++ Sbjct: 19 VLGAGSWGTVFAQMLHENGEEV-ILWARRKEIVDLINVSHTSPYVEESKITVRATNDLEE 77 Query: 103 V 103 + Sbjct: 78 I 78 >1Y8C-A nrPDB Length = 246 Score = 27.5 bits (60), Expect = 7.1, Method: Composition-based stats. Identities = 6/46 (13%), Positives = 14/46 (30%) Query: 69 VEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPD 114 V + + R E + K + G ++ +D + Sbjct: 185 VRDGEFYKRFDEEHEERAYKEEDIEKYLKHGQLNILDKVDCYSNKK 230 >2K8H-A nrPDB Length = 110 Score = 27.5 bits (60), Expect = 7.5, Method: Composition-based stats. Identities = 12/63 (19%), Positives = 20/63 (31%), Gaps = 5/63 (7%) Query: 45 GSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVI 104 G G G + VA+K V D + + + T + + K + Sbjct: 13 GEGA-----EGTCKEETALVAVKVVNADGAEMFFRIKSRTALKKLIDTYCKKQGISRNSV 67 Query: 105 RLL 107 R L Sbjct: 68 RFL 70 >5MIO-C nrPDB Length = 573 Score = 27.5 bits (60), Expect = 8.1, Method: Composition-based stats. Identities = 14/79 (17%), Positives = 27/79 (34%), Gaps = 16/79 (20%) Query: 127 QDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLID 186 LFD + ++ L+ QV+ H L++ +K+ID Sbjct: 194 GKLFDLLNKKAKLRVLEDGKQQVQVVGLQEH----------------LVNSADDVIKMID 237 Query: 187 FGSGALLKDTVYTDFDGTR 205 GS + + + +R Sbjct: 238 MGSACRTSGQTFANSNSSR 256 >4UBF-A nrPDB Length = 387 Score = 27.5 bits (60), Expect = 8.1, Method: Composition-based stats. Identities = 14/79 (17%), Positives = 27/79 (34%), Gaps = 16/79 (20%) Query: 127 QDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLID 186 LFD + ++ L+ QV+ H L++ +K+ID Sbjct: 201 GKLFDLLNKKAKLRVLEDGKQQVQVVGLQEH----------------LVNSADDVIKMID 244 Query: 187 FGSGALLKDTVYTDFDGTR 205 GS + + + +R Sbjct: 245 MGSACRTSGQTFANSNSSR 263 >3NPK-A nrPDB Length = 291 Score = 27.2 bits (59), Expect = 9.7, Method: Composition-based stats. Identities = 10/81 (12%), Positives = 22/81 (27%), Gaps = 11/81 (13%) Query: 92 LLKKVSSGFSGVIRLLDWFERPDSFVLILERPEP----VQDLFDFITERGALQEELARSF 147 + + V +F + +L + Q L + + Sbjct: 9 FIHHLEKNLPKVESFHPFFNEALALML---KAGGKHFRAQLLLSVVQSNK----PELLNQ 61 Query: 148 FWQVLEAVRHCHNCGVLHRDI 168 V A+ H ++H D+ Sbjct: 62 ALDVALALEFIHTYSLIHDDL 82 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.152 0.457 Lambda K H 0.267 0.0466 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 14,008,904 Number of Sequences: 36641 Number of extensions: 622341 Number of successful extensions: 6112 Number of sequences better than 10.0: 520 Number of HSP's better than 10.0 without gapping: 817 Number of HSP's successfully gapped in prelim test: 158 Number of HSP's that attempted gapping in prelim test: 1918 Number of HSP's gapped (non-prelim): 1164 length of query: 313 length of database: 10,336,785 effective HSP length: 97 effective length of query: 216 effective length of database: 6,782,608 effective search space: 1465043328 effective search space used: 1465043328 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 59 (27.1 bits)