BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P10902 (540 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1KNR-A nrPDB 1116 0.0 5KXJ-A nrPDB 1018 0.0 2E5V-A nrPDB 269 2e-72 2B76-A nrPDB 239 3e-63 3VR8-A nrPDB 191 1e-48 2H88-A nrPDB 184 8e-47 2BS2-A nrPDB 182 3e-46 2WDR-A nrPDB 181 9e-46 4YTP-A nrPDB 180 1e-45 5XMJ-A nrPDB 162 3e-40 1QO8-A nrPDB 124 1e-28 5ZYN-B nrPDB 101 8e-22 1KSU-A nrPDB 100 2e-21 1D4E-A nrPDB 95 9e-20 3GYX-A nrPDB 37 0.025 5L46-A nrPDB 35 0.087 4P9S-A nrPDB 35 0.088 1QVJ-A nrPDB 34 0.17 4CBQ-A nrPDB 33 0.25 4FL0-A nrPDB 33 0.26 4NEW-A nrPDB 33 0.34 5W1J-A nrPDB 33 0.43 3IHG-A nrPDB 32 0.53 2GAG-B nrPDB 32 0.58 4NTC-A nrPDB 32 0.61 4RPJ-A nrPDB 31 1.3 2WOV-A nrPDB 31 1.6 5JZM-A nrPDB 30 2.3 3AB1-A nrPDB 30 2.7 3UKH-A nrPDB 30 2.9 2DKH-A nrPDB 30 3.0 3MJ4-A nrPDB 30 3.2 4H7U-A nrPDB 29 4.8 4HA6-A nrPDB 29 4.8 1FOH-A nrPDB 29 5.3 5U8W-A nrPDB 29 5.5 4C3X-A nrPDB 29 5.6 2Q7V-A nrPDB 29 5.7 5UWY-A nrPDB 29 6.0 5MJK-A nrPDB 29 6.1 2GMH-A nrPDB 28 6.9 1XHC-A nrPDB 28 8.8 4EIQ-A nrPDB 28 9.2 3R9U-A nrPDB 28 9.4 >1KNR-A nrPDB Length = 540 Score = 1116 bits (2886), Expect = 0.0, Method: Compositional matrix adjust. Identities = 538/540 (99%), Positives = 539/540 (99%) Query: 1 MNTLPEHSCDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDET 60 MNTLPEHSCDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDET Sbjct: 1 MNTLPEHSCDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDET 60 Query: 61 DSIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTR 120 DSIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTR Sbjct: 61 DSIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTR 120 Query: 121 EGGHSHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLPGTRRVV 180 EGGHSHRRILHAADATGREVETTLVSKALNHPNIRVLER+NAVDLIVSDKIGLPGTRRVV Sbjct: 121 EGGHSHRRILHAADATGREVETTLVSKALNHPNIRVLERTNAVDLIVSDKIGLPGTRRVV 180 Query: 181 GAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVANLEF 240 GAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVANLEF Sbjct: 181 GAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVANLEF 240 Query: 241 NQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERGELAPRDIVARAIDHE 300 NQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERGELAPRDIVARAIDHE Sbjct: 241 NQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERGELAPRDIVARAIDHE 300 Query: 301 MKRLGADCMFLDISHKPADFIRQHFPMIYEKLLGLGIDLTQEPVPIVPAAHYTCGGVMVD 360 MKRLGADCMFLDISHKPADFIRQHFPMIYEKLLGLGIDLTQEPVPIVPAAHYTCGGVMVD Sbjct: 301 MKRLGADCMFLDISHKPADFIRQHFPMIYEKLLGLGIDLTQEPVPIVPAAHYTCGGVMVD 360 Query: 361 DHGRTDVEGLYAIGEVSYTGLHGANRMASNSLLECLVYGWSAAEDITRRMPYAHDISTLP 420 DHGRTDVEGLYAIGEVSYTGLHGAN MASNSLLECLVYGWSAAEDITRRMPYAHDISTLP Sbjct: 361 DHGRTDVEGLYAIGEVSYTGLHGANLMASNSLLECLVYGWSAAEDITRRMPYAHDISTLP 420 Query: 421 PWDESRVENPDERVVIQHNWHELRLFMWDYVGIVRTTKRLERALRRITMLQQEIDEYYAH 480 PWDESRVENPDERVVIQHNWHELRLFMWDYVGIVRTTKRLERALRRITMLQQEIDEYYAH Sbjct: 421 PWDESRVENPDERVVIQHNWHELRLFMWDYVGIVRTTKRLERALRRITMLQQEIDEYYAH 480 Query: 481 FRVSNNLLELRNLVQVAELIVRCAMMRKESRGLHFTLDYPELLTHSGPSILSPGNHYINR 540 FRVSNNLLELRNLVQVAELIVRCAMMRKESRGLHFTLDYPELLTHSGPSILSPGNHYINR Sbjct: 481 FRVSNNLLELRNLVQVAELIVRCAMMRKESRGLHFTLDYPELLTHSGPSILSPGNHYINR 540 >5KXJ-A nrPDB Length = 557 Score = 1018 bits (2633), Expect = 0.0, Method: Compositional matrix adjust. Identities = 485/540 (89%), Positives = 513/540 (95%) Query: 1 MNTLPEHSCDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDET 60 M T PE SCDVLIIGSGAAGLSLALRLA++H+VIVLSKGPV+EGSTFYAQGGIAAVFDET Sbjct: 1 MMTTPELSCDVLIIGSGAAGLSLALRLAEKHKVIVLSKGPVSEGSTFYAQGGIAAVFDET 60 Query: 61 DSIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTR 120 DSI SHVEDTLIAGAGICDRHAVEFVASNAR+CVQWLIDQGVLFDTH+QPNG+ESYHLTR Sbjct: 61 DSIASHVEDTLIAGAGICDRHAVEFVASNARTCVQWLIDQGVLFDTHVQPNGKESYHLTR 120 Query: 121 EGGHSHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLPGTRRVV 180 EGGHSHRRILHAADATG+EVETTLVS+A NHPNI+VLERSNAVDLI+SDK+GLPG RRVV Sbjct: 121 EGGHSHRRILHAADATGKEVETTLVSRAQNHPNIQVLERSNAVDLIISDKMGLPGPRRVV 180 Query: 181 GAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVANLEF 240 GAW+WNRNKE VETCHAK+VVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVANLEF Sbjct: 181 GAWIWNRNKEWVETCHAKSVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVANLEF 240 Query: 241 NQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERGELAPRDIVARAIDHE 300 NQFHPTALYHPQARNFLLTEALRGEGAYLKRPDG+RFMPD DERGELAPRDIVARAIDHE Sbjct: 241 NQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGSRFMPDVDERGELAPRDIVARAIDHE 300 Query: 301 MKRLGADCMFLDISHKPADFIRQHFPMIYEKLLGLGIDLTQEPVPIVPAAHYTCGGVMVD 360 MK+LGADCMFLDISHKP DF+RQHFPMIY KLL LG+DLT+EP+P+VPAAHYTCGGV+VD Sbjct: 301 MKQLGADCMFLDISHKPDDFVRQHFPMIYAKLLDLGMDLTKEPIPVVPAAHYTCGGVVVD 360 Query: 361 DHGRTDVEGLYAIGEVSYTGLHGANRMASNSLLECLVYGWSAAEDITRRMPYAHDISTLP 420 D+GRTDV+GLYAIGEVSYTGLHGANRMASNSLLECLVYGWSAA DI RRMP H + LP Sbjct: 361 DYGRTDVDGLYAIGEVSYTGLHGANRMASNSLLECLVYGWSAAMDIDRRMPSVHSVDALP 420 Query: 421 PWDESRVENPDERVVIQHNWHELRLFMWDYVGIVRTTKRLERALRRITMLQQEIDEYYAH 480 WDESRVEN DERVVIQHNWHELRL MWDYVGIVRTTKRLERALRRITMLQQEIDEYYA+ Sbjct: 421 AWDESRVENADERVVIQHNWHELRLLMWDYVGIVRTTKRLERALRRITMLQQEIDEYYAN 480 Query: 481 FRVSNNLLELRNLVQVAELIVRCAMMRKESRGLHFTLDYPELLTHSGPSILSPGNHYINR 540 FRVSNNLLELRNLVQVAELIVRCAMMRKESRGLHFTLDYP+ L SGPSILSP +INR Sbjct: 481 FRVSNNLLELRNLVQVAELIVRCAMMRKESRGLHFTLDYPQQLAESGPSILSPLTPHINR 540 >2E5V-A nrPDB Length = 472 Score = 269 bits (688), Expect = 2e-72, Method: Compositional matrix adjust. Identities = 194/520 (37%), Positives = 277/520 (53%), Gaps = 75/520 (14%) Query: 11 VLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDETDSIDSHVEDT 70 + IIGSG AGLS + L + + L + GST A+GG+AA DS + H +DT Sbjct: 2 IYIIGSGIAGLSAGVALRRAGKKVTLISKRIDGGSTPIAKGGVAASVGSDDSPELHAQDT 61 Query: 71 LIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTREGGHSHRRIL 130 + G G+CD V +V S A++ ++ G F EE L EGGH+ RR+L Sbjct: 62 IRVGDGLCDVKTVNYVTSEAKNVIETFESWGFEF--------EEDLRL--EGGHTKRRVL 111 Query: 131 HAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLPGTRRVVGAWVWNRNKE 190 H D TGRE+ L+ K I ++E V++ V D +V G R Sbjct: 112 HRTDETGREIFNFLL-KLAREEGIPIIE-DRLVEIRVKDG-------KVTGFVTEKRG-- 160 Query: 191 TVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVANLEFNQFHPTALYH 250 VE +VLATGG S +Y+Y++ + GDG+A+A++AG +A++EF QFHPT + Sbjct: 161 LVEDVDK--LVLATGGYSYLYEYSSTQSTNIGDGMAIAFKAGTILADMEFVQFHPT-VTS 217 Query: 251 PQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERGELAPRDIVARAIDHEMKRLGADCMF 310 FLLTE LRGEGA + +G RF+ ++D+RGELAPRDI++RAI EM L +F Sbjct: 218 LDGEVFLLTETLRGEGAQIINENGERFLFNYDKRGELAPRDILSRAIYIEM--LKGHKVF 275 Query: 311 LDISHKPADFIRQHFPMIYEKLLGLGIDLTQEPVPIVPAAHYTCGGVMVDDHGRTDVEGL 370 +D+S K DF R+ FP++ + L G + + +PI PAAH+ GG+ V+ G +++ L Sbjct: 276 IDLS-KIEDFERK-FPVVAKYLARHGHNY-KVKIPIFPAAHFVDGGIRVNIRGESNIVNL 332 Query: 371 YAIGEVSYTGLHGANRMASNSLLECLVYGWSAAEDITRRMPYAHDISTLPPWDESRVE-- 428 YAIGEVS +GLHGANR+ASNSLLE LV+G + LP + +S E Sbjct: 333 YAIGEVSDSGLHGANRLASNSLLEGLVFGIN-----------------LPRYVDSSWEGI 375 Query: 429 NPDERVV----IQHN----WHELRLFMWDYVGIVRTTKRLERALRRITMLQQEIDEYYAH 480 + D+ +V I N E+R W+ VGI+R ++L +A+ + Q Sbjct: 376 STDDGIVHSVRISGNKTLSLKEIRRINWENVGIIRNEEKLVKAINTYSSSTQ-------- 427 Query: 481 FRVSNNLLELRNLVQVAELIVRCAMMRKESRGLHFTLDYP 520 N ++ L A +RKESRG HF DYP Sbjct: 428 -----------NEAIISYLTALAAEIRKESRGNHFREDYP 456 >2B76-A nrPDB Length = 602 Score = 239 bits (609), Expect = 3e-63, Method: Compositional matrix adjust. Identities = 171/524 (32%), Positives = 262/524 (50%), Gaps = 55/524 (10%) Query: 32 QVIVLSKGPVTEGSTFYAQGGIAAVFDETDSIDSHVEDTLIAGAGICDRHAVEFVASNAR 91 ++ ++SK T AQGG AAV + DS + H DT+ G +C++ V++ + Sbjct: 32 KIALISKVYPMRSHTVAAQGGSAAVAQDHDSFEYHFHDTVAGGDWLCEQDVVDYFVHHCP 91 Query: 92 SCVQWLIDQGVLFDTHIQPNGEESYHLTREGGHSHRRILHAADATGREVETTLVSKALNH 151 + + L G + +P+G S ++ R GG R AAD TG + TL +L Sbjct: 92 TEMTQLELWGCPWSR--RPDG--SVNVRRFGGMKIERTWFAADKTGFHMLHTLFQTSLQF 147 Query: 152 PNIRVLERSNAVDLIVSDKIGLPGTRRVVGAWVWNRNKETVETCHAKAVVLATGGASKVY 211 P I+ + +D++V D V G N + T+ A AVV+ATGGA +VY Sbjct: 148 PQIQRFDEHFVLDILVDDG-------HVRGLVAMNMMEGTLVQIRANAVVMATGGAGRVY 200 Query: 212 QYTTNPDISSGDGIAMAWRAGCRVANLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKR 271 +Y TN I +GDG+ MA G + ++EF Q+HPT L L+TE RGEG L Sbjct: 201 RYNTNGGIVTGDGMGMALSHGVPLRDMEFVQYHPTGL---PGSGILMTEGCRGEGGILVN 257 Query: 272 PDGTRFMPDF------------DERGELAPRDIVARAIDHEMKRLG------ADCMFLDI 313 +G R++ D+ ++ EL PRD V++A HE ++ D ++LD+ Sbjct: 258 KNGYRYLQDYGMGPETPLGEPKNKYMELGPRDKVSQAFWHEWRKGNTISTPRGDVVYLDL 317 Query: 314 SHKPADFIRQHFPMIYEKLLG-LGIDLTQEPVPIVPAAHYTCGGVMVDDHGRTDVEGLYA 372 H + + P I E +G+D +EP+P+ P AHYT GG+ D + T ++GL+A Sbjct: 318 RHLGEKKLHERLPFICELAKAYVGVDPVKEPIPVRPTAHYTMGGIETDQNCETRIKGLFA 377 Query: 373 IGEVSYTGLHGANRMASNSLLECLVYGWSAAEDITRRMPYAHDISTLP-PWDESRVENPD 431 +GE S GLHGANR+ SNSL E +V+G A E T R A + + + VE Sbjct: 378 VGECSSVGLHGANRLGSNSLAELVVFGRLAGEQATERAATAGNGNEAAIEAQAAGVEQRL 437 Query: 432 ERVVIQ---HNWHELR----LFMWDYVGIVRTTKRLERALRRITMLQQEIDEYYAHFRVS 484 + +V Q NW ++R L M + GI RT + +++ + ++ LQ E + R++ Sbjct: 438 KDLVNQDGGENWAKIRDEMGLAMEEGCGIYRTPELMQKTIDKLAELQ----ERFKRVRIT 493 Query: 485 NN----------LLELRNLVQVAELIVRCAMMRKESRGLHFTLD 518 + +EL + + VAE + AM RKESRG H LD Sbjct: 494 DTSSVFNTDLLYTIELGHGLNVAECMAHSAMARKESRGAHQRLD 537 >3VR8-A nrPDB Length = 645 Score = 191 bits (484), Expect = 1e-48, Method: Compositional matrix adjust. Identities = 175/557 (31%), Positives = 268/557 (48%), Gaps = 56/557 (10%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQ-HQVIVLSKGPVTEGSTFYAQGGIAAVFDETDSID 64 +H+ DV+IIG+G AGL A+ L + + V++K T T AQGGI A + D Sbjct: 39 DHAYDVVIIGAGGAGLRAAMGLGEAGFKTAVVTKMFPTRSHTTAAQGGINAALGSMNPDD 98 Query: 65 S--HVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTREG 122 H DT + D++A+ ++ NA V L + G+ F P G+ + G Sbjct: 99 WKWHFYDTAKGSDWLGDQNAMHYLTRNAVEAVTELENFGMPFSR--TPEGK--IYQRSFG 154 Query: 123 GHSH--------RRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLP 174 G S+ +R AD TG + TL +L +E A+DL++ Sbjct: 155 GQSNNYGKGGVAKRTCCVADRTGHSMLHTLYGNSLRCHCTFFIEYF-ALDLLMDKG---- 209 Query: 175 GTRRVVGAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCR 234 R VG T+ +K ++ATGG + Y T +++GDG A+A RAG Sbjct: 210 ---RCVGVIALCLEDGTIHRFRSKRTIVATGGYGRAYFSCTTAHMNTGDGTALATRAGIA 266 Query: 235 VANLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERG-ELAPRDIV 293 + +LEF QFHPT +Y L+TE RGEG +L +G RFM + + +LA RD+V Sbjct: 267 LEDLEFIQFHPTGIY---GVGCLITEGSRGEGGFLVNSEGERFMERYAPKAKDLASRDVV 323 Query: 294 ARAIDHE-MKRLGA----DCMFLDISHKPADFIRQHFPMIYEKL-LGLGIDLTQEPVPIV 347 +RA E M+ G D ++L + H PA+ + Q P I E + G+D+T+EP+P++ Sbjct: 324 SRAETIEIMEGRGVGPEKDHIYLQLHHLPAEQLHQRLPGISETAKIFAGVDVTKEPIPVI 383 Query: 348 PAAHYTCGGVMVD----------DHGRTDVEGLYAIGEVSYTGLHGANRMASNSLLECLV 397 P HY GG+ + + G V GLYA GE + +HGANR+ +NSLL+ +V Sbjct: 384 PTVHYNMGGIPTNYKAQVIKYTKEGGDKIVPGLYACGECACHSVHGANRLGANSLLDAVV 443 Query: 398 YGWSAAEDITRRMPYAHDISTLPPW-DESRVENPDERVVIQHN--WHELRL----FMWDY 450 +G + + +I + I LP E + N D + ELRL M + Sbjct: 444 FGRACSINIKEELKPDEKIPELPEGAGEESIANLDAVRYANGDVPTAELRLTMQKTMQKH 503 Query: 451 VGIVRTTKRLERALRRITMLQQEIDEYYAHFRV---SNNL---LELRNLVQVAELIVRCA 504 G+ R L ++++ L +E+ R +++L LEL+NL+ A + A Sbjct: 504 AGVFRRGDILAEGVKKMMDLSKELKRLKTTDRSLIWNSDLTESLELQNLMLNATQTIVAA 563 Query: 505 MMRKESRGLHFTLDYPE 521 RKESRG H D+P+ Sbjct: 564 ENRKESRGAHARDDFPK 580 >2H88-A nrPDB Length = 621 Score = 184 bits (467), Expect = 8e-47, Method: Compositional matrix adjust. Identities = 156/520 (30%), Positives = 240/520 (46%), Gaps = 60/520 (11%) Query: 42 TEGSTFYAQGGIAAVFD--ETDSIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLID 99 T T AQGGI A E D+ H DT+ + D+ A+ ++ A + V L + Sbjct: 53 TRSHTVAAQGGINAALGNMEDDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPAAVIELEN 112 Query: 100 QGVLFD------THIQPNGEESYHLTREGGHSHRRILHAADATGREVETTLVSKALNHPN 153 G+ F + + G +S + GG +HR AD TG + TL ++L + Sbjct: 113 YGMPFSRTEEGKIYQRAFGGQSLQFGK-GGQAHR-CCCVADRTGHSLLHTLYGRSLRYDT 170 Query: 154 IRVLERSNAVDLIVSDKIGLPGTRRVVGAWVWNRNKETVETCHAKAVVLATGGASKVYQY 213 +E A+DL++ + G R V A T+ AK V+ATGG + Y Sbjct: 171 SYFVEYF-ALDLLMEN-----GECRGVIALCIEDG--TIHRFRAKNTVIATGGYGRTYFS 222 Query: 214 TTNPDISSGDGIAMAWRAGCRVANLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPD 273 T+ S+GDG AM RAG +LEF QFHPT +Y L+TE RGEG L Sbjct: 223 CTSAHTSTGDGTAMVTRAGLPCQDLEFVQFHPTGIY---GAGCLITEGCRGEGGILINSQ 279 Query: 274 GTRFMPDFDERG-ELAPRDIVARAIDHEMKRLGADC------MFLDISHKPADFIRQHFP 326 G RFM + +LA RD+V+R++ E+ R G C ++L + H P + P Sbjct: 280 GERFMERYAPVAKDLASRDVVSRSMTIEI-REGRGCGPEKDHVYLQLHHLPPQQLATRLP 338 Query: 327 MIYEK-LLGLGIDLTQEPVPIVPAAHYTCGGVMVDDHGRTD---------VEGLYAIGEV 376 I E ++ G+D+T+EP+P++P HY GG+ + G+ V GLYA GE Sbjct: 339 GISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVITHVNGEDKVVPGLYACGEA 398 Query: 377 SYTGLHGANRMASNSLLECLVYGWSAAEDITRRMPYAHDISTLPP-WDESRVENPDE--- 432 + +HGANR+ +NSLL+ +V+G + A I + ++ P E V N D+ Sbjct: 399 ASASVHGANRLGANSLLDLVVFGRACALTIAETCKPGEPVPSIKPNAGEESVANLDKLRF 458 Query: 433 ---RVVIQHNWHELRLFMWDYVGIVRTTKRLERALRRITMLQQEIDEYYAHFRVSN---- 485 + ++ M + + RT L+ +++ + +++ AH + + Sbjct: 459 ADGTIRTSEARLNMQKTMQSHAAVFRTGSILQEGCEKLSQIYRDL----AHLKTFDRGIV 514 Query: 486 ------NLLELRNLVQVAELIVRCAMMRKESRGLHFTLDY 519 LEL+NL+ A + A RKESRG H DY Sbjct: 515 WNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDY 554 >2BS2-A nrPDB Length = 660 Score = 182 bits (463), Expect = 3e-46, Method: Compositional matrix adjust. Identities = 165/565 (29%), Positives = 254/565 (44%), Gaps = 68/565 (12%) Query: 9 CDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGSTFYAQGGIAAVFDET-----DS 62 CD L+IG G AGL A+ + IVLS PV + AQGG+ A + D+ Sbjct: 6 CDSLVIGGGLAGLRAAVATQQKGLSTIVLSLIPVKRSHSAAAQGGMQASLGNSKMSDGDN 65 Query: 63 IDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGV------------LFDTHIQP 110 D H DT+ CD+ + A ++ L GV + + Sbjct: 66 EDLHFMDTVKGSDWGCDQKVARMFVNTAPKAIRELAAWGVPWTRIHKGDRMAIINAQKTT 125 Query: 111 NGEESY-----HLTREGGHSHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDL 165 EE + H GG R + ADATG + + ++ L + + +R A+ L Sbjct: 126 ITEEDFRHGLIHSRDFGGTKKWRTCYTADATGHTMLFAVANECLKL-GVSIQDRKEAIAL 184 Query: 166 IVSDKIGLPGTRRVVGAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGI 225 I D + GA V + + AK ++ATGG ++Y+ TTN + G G Sbjct: 185 IHQDG-------KCYGAVVRDLVTGDIIAYVAKGTLIATGGYGRIYKNTTNAVVCEGTGT 237 Query: 226 AMAWRAG-CRVANLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFD-E 283 A+A G ++ N+E QFHPT L+ LLTE RG+G L+ DG RFMPD++ E Sbjct: 238 AIALETGIAQLGNMEAVQFHPTPLF---PSGILLTEGCRGDGGILRDVDGHRFMPDYEPE 294 Query: 284 RGELAPRDIVAR-AIDHEMKRLGADC-----MFLDISHKPADFIRQHFPMIYEKLLGL-G 336 + ELA RD+V+R I+H K G ++LDIS I + + E G Sbjct: 295 KKELASRDVVSRRMIEHIRKGKGVQSPYGQHLWLDISILGRKHIETNLRDVQEICEYFAG 354 Query: 337 IDLTQEPVPIVPAAHYTCGGVMVDDHGRTDVEGLYAIGEVSYTGLHGANRMASNSLLECL 396 ID ++ P++P HY+ GG+ D G ++GL++ GE + +HG NR+ NS+ E + Sbjct: 355 IDPAEKWAPVLPMQHYSMGGIRTDYRGEAKLKGLFSAGEAACWDMHGFNRLGGNSVSEAV 414 Query: 397 VYGWSAAEDITRRMPYAH-DIST---------LPPWDESRVENPDERVVIQHNWHELRLF 446 V G E D+ T + +S VE+ V + + ++ Sbjct: 415 VAGMIVGEYFAEHCANTQVDLETKTLEKFVKGQEAYMKSLVESKGTEDVFKIK-NRMKDV 473 Query: 447 MWDYVGIVRTTKRLERALRRITMLQQEIDEYYAHFRVSNNLL----ELRN------LVQV 496 M D VGI R LE+A++ + +E+ + + + N L EL +++V Sbjct: 474 MDDNVGIFRDGPHLEKAVKEL----EELYKKSKNVGIKNKRLHANPELEEAYRVPMMLKV 529 Query: 497 AELIVRCAMMRKESRGLHFTLDYPE 521 A + + A+ R ESRG H DYP+ Sbjct: 530 ALCVAKGALDRTESRGAHNREDYPK 554 >2WDR-A nrPDB Length = 588 Score = 181 bits (458), Expect = 9e-46, Method: Compositional matrix adjust. Identities = 176/566 (31%), Positives = 261/566 (46%), Gaps = 69/566 (12%) Query: 4 LPEHSCDVLIIGSGAAGLSLALRLADQHQVI-VLSKGPVTEGSTFYAQGGIAAVFDET-- 60 LP D ++IG+G AG+ AL+++ Q +LSK T T AQGGI T Sbjct: 3 LPVREFDAVVIGAGGAGMRAALQISQSGQTCALLSKVFPTRSHTVSAQGGITVALGNTHE 62 Query: 61 DSIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFD------THIQPNGEE 114 D+ + H+ DT+ I D+ A+E++ + L G+ F + +P G + Sbjct: 63 DNWEWHMYDTVKGSDYIGDQDAIEYMCKTGPEAILELEHMGLPFSRLDDGRIYQRPFGGQ 122 Query: 115 SYHLTREGGHSHRRILHAADATGREVETTLVSKAL-NHPNIRVLERSNAVDLIVSDKIGL 173 S + GG R AAD TG + TL + L NH I A+DL V ++ G Sbjct: 123 SKNF---GGEQAARTAAAADRTGHALLHTLYQQNLKNHTTI--FSEWYALDL-VKNQDGA 176 Query: 174 PGTRRVVGAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGC 233 VVG V A+A VLATGGA ++YQ TTN I++GDG+ MA RAG Sbjct: 177 -----VVGCTALCIETGEVVYFKARATVLATGGAGRIYQSTTNAHINTGDGVGMAIRAGV 231 Query: 234 RVANLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERG-ELAPRDI 292 V ++E QFHPT + L+TE RGEG YL G RFM + +LA RD+ Sbjct: 232 PVQDMEMWQFHPTGI---AGAGVLVTEGCRGEGGYLLNKHGERFMERYAPNAKDLAGRDV 288 Query: 293 VARAIDHEMKRLGADC-------MFLDISHKPADFIRQHFPMIYEKLLGLG-IDLTQEPV 344 VAR+I E+ R G C L + H + + P I E +D +EP+ Sbjct: 289 VARSIMIEI-REGRGCDGPWGPHAKLKLDHLGKEVLESRLPGILELSRTFAHVDPVKEPI 347 Query: 345 PIVPAAHYTCGGV---------MVDDHGR-TDVEGLYAIGEVSYTGLHGANRMASNSLLE 394 P++P HY GG+ V++ G V GL+A+GE++ +HGANR+ NSLL+ Sbjct: 348 PVIPTCHYMMGGIPTKVTGQALTVNEKGEDVVVPGLFAVGEIACVSVHGANRLGGNSLLD 407 Query: 395 CLVYGWSAAEDITRRMPYAHDISTLPPWDESRVENP-------------DERVVIQHNWH 441 +V+G +A + + + L ES VE ++ V I+ Sbjct: 408 LVVFGRAAGLHLQESIA---EQGALRDASESDVEASLDRLNRWNNNRNGEDPVAIRKALQ 464 Query: 442 ELRLFMWDYVGIVRTTKRLERALRRITMLQQ-----EIDEYYAHFRVSN-NLLELRNLVQ 495 E M + R + + L ++ ++++ +D+ + F LEL NL++ Sbjct: 465 EC---MQHNFSVFREGDAMAKGLEQLKVIRERLKNARLDDTSSEFNTQRVECLELDNLME 521 Query: 496 VAELIVRCAMMRKESRGLHFTLDYPE 521 A A R ESRG H D+P+ Sbjct: 522 TAYATAVSANFRTESRGAHSRFDFPD 547 >4YTP-A nrPDB Length = 664 Score = 180 bits (457), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 160/518 (30%), Positives = 239/518 (46%), Gaps = 52/518 (10%) Query: 42 TEGSTFYAQGGIAAVFD--ETDSIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLID 99 T T AQGGI A E D+ H DT+ + D+ A+ ++ A + V L + Sbjct: 96 TRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPASVVELEN 155 Query: 100 QGVLFD------THIQPNGEESYHLTREGGHSHRRILHAADATGREVETTLVSKALNHPN 153 G+ F + + G +S + GG +HR AD TG + TL ++L + Sbjct: 156 YGMPFSRTEDGKIYQRAFGGQSLKFGK-GGQAHR-CCCVADRTGHSLLHTLYGRSLRYDT 213 Query: 154 IRVLERSNAVDLIVSDKIGLPGTRRVVGAWVWNRNKETVETCHAKAVVLATGGASKVYQY 213 +E A+DL++ + G R V A ++ A+ V+ATGG + Y Sbjct: 214 SYFVEYF-ALDLLMEN-----GECRGVIALCIEDG--SIHRIRARNTVVATGGYGRTYFS 265 Query: 214 TTNPDISSGDGIAMAWRAGCRVANLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPD 273 T+ S+GDG AM RAG +LEF QFHPT +Y L+TE RGEG L Sbjct: 266 CTSAHTSTGDGTAMVTRAGLPCQDLEFVQFHPTGIY---GAGCLITEGCRGEGGILINSQ 322 Query: 274 GTRFMPDFDERG-ELAPRDIVARAIDHEMKRLGADC------MFLDISHKPADFIRQHFP 326 G RFM + +LA RD+V+R++ E+ R G C ++L + H P + + P Sbjct: 323 GERFMERYAPVAKDLASRDVVSRSMTLEI-REGRGCGPEKDHVYLQLHHLPPEQLAVRLP 381 Query: 327 MIYEK-LLGLGIDLTQEPVPIVPAAHYTCGGVMVDDHGRT---------DVEGLYAIGEV 376 I E ++ G+D+T+EP+P++P HY GG+ + G+ V GLYA GE Sbjct: 382 GISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVLRHVNGQDQVVPGLYACGEA 441 Query: 377 SYTGLHGANRMASNSLLECLVYGWSAAEDITRRMPYAHDISTLPP-WDESRVENPDERVV 435 + +HGANR+ +NSLL+ +V+G + A I + ++ P E V N D+ Sbjct: 442 ACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDKVPSIKPNAGEESVMNLDKLRF 501 Query: 436 IQHNWH--ELRL----FMWDYVGIVRTTKRLERALRRITMLQQEIDEYYAHFR--VSNN- 486 ELRL M + + R L+ +I L ++ R V N Sbjct: 502 ANGTIRTSELRLSMQKSMQSHAAVFRVGSVLQEGCEKILRLYGDLQHLKTFDRGMVWNTD 561 Query: 487 ---LLELRNLVQVAELIVRCAMMRKESRGLHFTLDYPE 521 LEL+NL+ A + A RKESRG H D+ E Sbjct: 562 LVETLELQNLMLCALQTIYGAEARKESRGAHAREDFKE 599 >5XMJ-A nrPDB Length = 627 Score = 162 bits (410), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 162/566 (28%), Positives = 249/566 (43%), Gaps = 70/566 (12%) Query: 10 DVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGSTFYAQGGIAA-----VFDETDSI 63 DVL IG AG +A+ + + I+LS P + AQGG+ A + + DS Sbjct: 7 DVLCIGGALAGERVAVEASMAGLKTIMLSLVPPRRSHSSAAQGGMQAALGNAIMGDGDSP 66 Query: 64 DSHVEDTLIAGAGICDRHAVEFVASNA----RSCVQWLI-------------DQGVLFDT 106 D H DT+ CD+ A A R W + G F+ Sbjct: 67 DVHFADTVKGSDWGCDQEVARIFADTAPIVMREVAHWGVPWNRVVPGKHTYYKGGKPFEA 126 Query: 107 HIQPNGEESYHLTREGGHSHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDLI 166 + H GG + R + AD TGR V TL +K L + + V +R A LI Sbjct: 127 EEKAEKAGLIHARAFGGTAAWRTCYTADGTGRSVLNTLDTKCLQY-GVTVHDRMQAEALI 185 Query: 167 VSDKIGLPGTRRVVGAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIA 226 L R + R E V A + ++ATGG ++Y+ TTN I G G Sbjct: 186 HDGGNCLGCIARCL------RTGELVAYL-ATSTLIATGGYGRIYKATTNAVICDGGGQI 238 Query: 227 MAWRAG-CRVANLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFD-ER 284 +A G + N+E QFHPT + L+TE RG+G L + RFMPD++ ++ Sbjct: 239 IALDTGLVPMGNMEAVQFHPTGTV---PTDILVTEGCRGDGGTLLDVNQYRFMPDYEPDK 295 Query: 285 GELAPRDIVARAIDHEMKR-LG-----ADCMFLDISHKPADFIRQHFPMIYEKLLG-LGI 337 +LA RD+V+R + M++ LG D ++LDI H I +Y+ LG+ Sbjct: 296 AQLASRDVVSRRMTEHMRKGLGVKSPYGDHLWLDIRHLGEKHITTKLREVYDICTNFLGV 355 Query: 338 DLTQEPVPIVPAAHYTCGGVMVDDHGRT-DVEGLYAIGEVSYTGLHGANRMASNSLLECL 396 + + +P+ P HY+ GGV + G ++GL++ GE + +HG NR+ NSL E + Sbjct: 356 NPIHQLIPVRPTHHYSMGGVRTNRDGAAYGLKGLFSAGESACWDMHGFNRLGGNSLAETV 415 Query: 397 VYGWSAAEDITRRMPYAHDISTLPPWDESRVENPDERV-----------VIQHNWHELRL 445 V G E + A P + VE+ ++V + N ++R Sbjct: 416 VAGRYIGERMVEFTKGA-----TPSFGMQYVEDAHKKVQERITDIVTGRKGKENTFKIRD 470 Query: 446 FMWDY----VGIVRTTKRLERALRRITML---QQEIDEYYAHFRVSNNL---LELRNLVQ 495 M D VGI R L++A+ ++ L Q+I A ++ L L +R +++ Sbjct: 471 EMHDIMMEGVGIFRNGTDLQKAVNKLEELYDRSQKISLSSACKGMNPELSTALRIRGMLK 530 Query: 496 VAELIVRCAMMRKESRGLHFTLDYPE 521 +A+ A+ R ESRG H D+PE Sbjct: 531 LAQCTAYGALDRTESRGAHTREDFPE 556 >1QO8-A nrPDB Length = 566 Score = 124 bits (310), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 134/479 (27%), Positives = 209/479 (43%), Gaps = 110/479 (22%) Query: 5 PEHSCDVLIIGSGAAGL--SLALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDET-- 60 P + VL++G+G+AG SLA + A + VI++ K P + G++ + GG+ AV + Sbjct: 118 PSETTQVLVVGAGSAGFNASLAAKKAGAN-VILVDKAPFSGGNSMISAGGMNAVGTKQQT 176 Query: 61 -----DSIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEES 115 D ++ +ED + G D V +A + VQWL G D Sbjct: 177 AHGVEDKVEWFIEDAMKGGRQQNDIKLVTILAEQSADGVQWLESLGANLDD--------- 227 Query: 116 YHLTREGG----HSHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKI 171 L R GG +HR H ++G E+ TL KA I S V L+V+D Sbjct: 228 --LKRSGGARVDRTHRP--HGGKSSGPEIIDTL-RKAAKEQGIDTRLNSRVVKLVVNDD- 281 Query: 172 GLPGTRRVVGAWVWNRNKETVETCHAKAVVLATGGASK-----VYQYTTNPDISS----- 221 VVGA V ++ AK+VVLATGG Y T D++S Sbjct: 282 -----HSVVGAVVHGKH-TGYYMIGAKSVVLATGGYGMNKEMIAYYRPTMKDMTSSNNIT 335 Query: 222 --GDGIAMAWRAGCRVANLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMP 279 GDG+ MA G + ++++ Q HPT + L++E +RG GA + DG RF+ Sbjct: 336 ATGDGVLMAKEIGASMTDIDWVQAHPTV---GKDSRILISETVRGVGAVMVNKDGNRFIS 392 Query: 280 DFDERGELAPRDIVARAIDHEMKRLG--ADCMFLDISHKPADFIR--QHFPMIYE----- 330 EL RD + AI +K+ G A +F + +K A +R H M+Y+ Sbjct: 393 ------ELTTRDKASDAI---LKQPGQFAWIIFDNQLYKKAKMVRGYDHLEMLYKGDTVE 443 Query: 331 ---KLLGLGI-----------------------------DLTQEP---VPIVPAAHYTCG 355 K G+ + ++TQ P V + P H+T G Sbjct: 444 QLAKSTGMKVADLAKTVSDYNGYVASGKDTAFGRADMPLNMTQSPYYAVKVAPGIHHTMG 503 Query: 356 GVMVD------DHGRTDVEGLYAIGEVSYTGLHGANRMASNSLLECLVYGWSAAEDITR 408 GV ++ D ++GL+A GEV+ G+HG NR+ N++ + +V+G A ++ + Sbjct: 504 GVAINTTASVLDLQSKPIDGLFAAGEVT-GGVHGYNRLGGNAIADTVVFGRIAGDNAAK 561 >5ZYN-B nrPDB Length = 471 Score = 101 bits (252), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 123/486 (25%), Positives = 204/486 (41%), Gaps = 111/486 (22%) Query: 11 VLIIGSGAAGLSLALRLADQHQ--VIVLSKGPVTEGSTFYAQGGIAAVFDET-------D 61 V++IGSG AGL+ + RL +++ V++L K G++ A GI +T D Sbjct: 7 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMD 66 Query: 62 SIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTRE 121 + + ++DTL + G ++ + ++S ++WL + FD + L + Sbjct: 67 TPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQTE---FDLKLD-------LLAQL 116 Query: 122 GGHSHRRILHAADAT--GREVETTLVSKALNHPNIRVLERSNAVDLIVSDK---IGLPGT 176 GGHS R ++ G E+ L SK L + + SN V ++++ + I L Sbjct: 117 GGHSVPRTHRSSGKLPPGFEIVQAL-SKKLKDISSK---DSNLVQIMLNSEVVDIELDNQ 172 Query: 177 RRVVGAWVW--NRNKETVETCHAKAVVLATGG------------ASKVYQYTTNPDISSG 222 V G N N++ +++ H VV +GG + ++ TTN ++G Sbjct: 173 GHVTGVVYMDENGNRKIMKSHH---VVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTG 229 Query: 223 DGIAMAWRAGCRVANLEFNQFHPTALYHPQAR----NFLLTEALRGEGAYLKRP-DGTRF 277 DG + + G + +++ Q HPT P R FL EALRG G L P G RF Sbjct: 230 DGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRF 289 Query: 278 M-----------------PDFDERGELAPRDIVARAIDHEMKRLGADCMFLDISHKPADF 320 P D R L D V + + + + +S D Sbjct: 290 TNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSIN--DL 347 Query: 321 IRQH--------------------------FPMIYEKLLGLGIDLTQEPV----PIVPAA 350 IRQ+ P+I D++ E + P Sbjct: 348 IRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIIN---AFDKDISTESTVYVGEVTPVV 404 Query: 351 HYTCGGVMVDDHGRTDVE--------GLYAIGEVSYTGLHGANRMASNSLLECLVYGWSA 402 H+T GGV +++ + + G++A GEVS G+HGANR+ +SLLEC+V+G +A Sbjct: 405 HFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVS-GGVHGANRLGGSSLLECVVFGKTA 463 Query: 403 AEDITR 408 A++I + Sbjct: 464 ADNIAK 469 >1KSU-A nrPDB Length = 571 Score = 100 bits (248), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 117/457 (25%), Positives = 189/457 (41%), Gaps = 98/457 (21%) Query: 21 LSLALRLADQ-HQVIVLSKGPVTEGSTFYAQGGIAAVFDE-------TDSIDSHVEDTLI 72 S A+ D +VI++ K PV G+ A GG+ A + + TDS + EDT+ Sbjct: 139 FSAAISATDSGAKVILIEKEPVIGGNAKLAAGGMNAAWTDQQKAKKITDSPELMFEDTMK 198 Query: 73 AGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTREGGHSHRRILHA 132 G I D V+ ++S+++ V W+ G T + G S + +HR A Sbjct: 199 GGQNINDPALVKVLSSHSKDSVDWMTAMGADL-TDVGMMGGASVN------RAHRPTGGA 251 Query: 133 ADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLPG--TRRVVGAWVWNRNKE 190 G V L A+ NI + + ++++ DK + G + + + W + Sbjct: 252 G--VGAHVVQVLYDNAVKR-NIDLRMNTRGIEVLKDDKGTVKGILVKGMYKGYYWVK--- 305 Query: 191 TVETCHAKAVVLATGGASKVYQ------------YTTNPDISSGDGIAMAWRAGCRVANL 238 A AV+LATGG +K + +TN + GDG+ +A AG + ++ Sbjct: 306 ------ADAVILATGGFAKNNERVAKLDPSLKGFISTNQPGAVGDGLDVAENAGGALKDM 359 Query: 239 EFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERGELAPRDIVARAI- 297 ++ Q HPT ++TEA+RG GA L +G RF+ E+ RD + AI Sbjct: 360 QYIQAHPTLSVKG---GVMVTEAVRGNGAILVNREGKRFV------NEITTRDKASAAIL 410 Query: 298 ------------DHEMKRLGADCMFLDISHKP-ADFIRQHFPMI-------------YEK 331 D K L ++ + P AD + + M Y Sbjct: 411 AQTGKSAYLIFDDSVRKSLSKIDKYIGLGVAPTADSLVKLGKMEGIDGKALTETVARYNS 470 Query: 332 LLGLGIDLTQE--------------PVPIVPAAHYTCGGVMVDDHG------RTDVEGLY 371 L+ G D E + + P HYT GGVM+D + + GLY Sbjct: 471 LVSSGKDTDFERPNLPRALNEGNYYAIEVTPGVHYTMGGVMIDTKAEVMNAKKQVIPGLY 530 Query: 372 AIGEVSYTGLHGANRMASNSLLECLVYGWSAAEDITR 408 GEV+ G+HGANR+ N++ + + +G A E+ + Sbjct: 531 GAGEVT-GGVHGANRLGGNAISDIITFGRLAGEEAAK 566 >1D4E-A nrPDB Length = 572 Score = 94.7 bits (234), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 122/437 (27%), Positives = 178/437 (40%), Gaps = 98/437 (22%) Query: 32 QVIVLSKGPVTEGSTFYAQGGIAAVFDE-------TDSIDSHVEDTLIAGAGICDRHAVE 84 +VI+L K P+ G+T A GG+ A + D ++DT+ G I D V+ Sbjct: 151 KVILLEKEPIPGGNTKLAAGGMNAAETKPQAKLGIEDKKQIMIDDTMKGGRNINDPELVK 210 Query: 85 FVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTREGGHSHRRILHAADATGREVETTL 144 +A+N+ + WL G T + G S + SHR A G V L Sbjct: 211 VLANNSSDSIDWLTSMGADM-TDVGRMGGASVN------RSHRPTGGAG--VGAHVAQVL 261 Query: 145 VSKALNH-PNIRVLERSNAVDLIVSDKIGLPGTRRVVGAWVWNRNKETVETCHAKAVVLA 203 A+ +IR+ R V I+ D G +V G V A AVV+A Sbjct: 262 WDNAVKRGTDIRLNSR---VVRILEDASG-----KVTGVLVKGE-YTGYYVIKADAVVIA 312 Query: 204 TGGASK----VYQY--------TTNPDISSGDGIAMAWRAGCRVANLEFNQFHPTALYHP 251 GG +K V +Y TN ++GDG+ +A +AG +L++ Q HPT Y P Sbjct: 313 AGGFAKNNERVSKYDPKLKGFKATNHPGATGDGLDVALQAGAATRDLQYIQAHPT--YSP 370 Query: 252 QARNFLLTEALRGEGAYLKRPDGTRFMPDFDERGELAPRDIVARAIDHEMKRLGADCMFL 311 A ++TEA+RG GA + +G RFM E+ RD + AI + K A +F Sbjct: 371 -AGGVMITEAVRGNGAIVVNREGNRFM------NEITTRDKASAAI-LQQKGESAYLVFD 422 Query: 312 DISHKPADFIRQ--HFPMI--------------------------YEKLLGLGIDLTQE- 342 D K I H ++ Y + G D E Sbjct: 423 DSIRKSLKAIEGYVHLNIVKEGKTIEELAKQIDVPAAELAKTVTAYNGFVKSGKDAQFER 482 Query: 343 -------------PVPIVPAAHYTCGGVMVDDHGRTDVE-------GLYAIGEVSYTGLH 382 + I PA H+T GG+++D E GLYA GEV+ G+H Sbjct: 483 PDLPRELVVAPFYALEIAPAVHHTMGGLVIDTKAEVKSEKTAKPITGLYAAGEVT-GGVH 541 Query: 383 GANRMASNSLLECLVYG 399 GANR+ N++ + + YG Sbjct: 542 GANRLGGNAISDIVTYG 558 >3GYX-A nrPDB Length = 662 Score = 36.6 bits (83), Expect = 0.025, Method: Compositional matrix adjust. Identities = 73/312 (23%), Positives = 123/312 (39%), Gaps = 90/312 (28%) Query: 6 EHSCDVLIIGSGAAGLSLAL---RLADQH----QVIVLSKGPVTEGSTFYAQGGIAAVFD 58 EHS D+L++G G A R AD++ +++++ K + E S AQG Sbjct: 20 EHSVDLLMVGGGMGNCGAAFEAVRWADKYAPEAKILLVDKASL-ERSGAVAQG------- 71 Query: 59 ETDSIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDT--HIQPNGEESY 116 +I+++ + D +A ++V R+ + L+ + +++D H+ ++S Sbjct: 72 -LSAINTY----------LGDNNADDYV-RMVRTDLMGLVREDLIYDLGRHV----DDSV 115 Query: 117 HLTREGG--------HSHRRILHAADATGR--------------------EVETTLVSKA 148 HL E G H H A A G+ E +V++A Sbjct: 116 HLFEEWGLPVWIKDEHGHNLDGAQAKAAGKSLRNGDKPVRSGRWQIMINGESYKVIVAEA 175 Query: 149 LNHP--NIRVLERSNAVDLIVSDKIGLPGTRRVVGAWVWNRNKETVETCHAKAVVLATGG 206 + R++ER V L++ R+ GA +N V A A+V+A GG Sbjct: 176 AKNALGQDRIIERIFIVKLLLDKNT----PNRIAGAVGFNLRANEVHIFKANAMVVACGG 231 Query: 207 ASKVYQYTTNPDISSGDGIAMAW--------------RAGCRVANLEFNQFHPTAL---Y 249 A VY+ S G+G+ AW + G + +E N+F P Y Sbjct: 232 AVNVYR-----PRSVGEGMGRAWYPVWNAGSTYTMCAQVGAEMTMME-NRFVPARFKDGY 285 Query: 250 HPQARNFLLTEA 261 P FLL +A Sbjct: 286 GPVGAWFLLFKA 297 >5L46-A nrPDB Length = 841 Score = 35.0 bits (79), Expect = 0.087, Method: Compositional matrix adjust. Identities = 19/45 (42%), Positives = 27/45 (60%), Gaps = 2/45 (4%) Query: 9 CDVLIIGSGAAGLSLALRLAD--QHQVIVLSKGPVTEGSTFYAQG 51 + +IIG G G+SLA LA V++L K +T GST++A G Sbjct: 23 AETVIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAG 67 >4P9S-A nrPDB Length = 848 Score = 35.0 bits (79), Expect = 0.088, Method: Compositional matrix adjust. Identities = 19/45 (42%), Positives = 27/45 (60%), Gaps = 2/45 (4%) Query: 9 CDVLIIGSGAAGLSLALRLAD--QHQVIVLSKGPVTEGSTFYAQG 51 + +IIG G G+SLA LA V++L K +T GST++A G Sbjct: 24 AETVIIGGGCVGVSLAYHLAKAGMRDVVLLEKSELTAGSTWHAAG 68 >1QVJ-A nrPDB Length = 292 Score = 33.9 bits (76), Expect = 0.17, Method: Compositional matrix adjust. Identities = 20/68 (29%), Positives = 30/68 (44%), Gaps = 5/68 (7%) Query: 77 ICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTREGGHSHRRILHAADAT 136 + +H ++FVA + C +W I G+ + P + S L RE G L A Sbjct: 133 VSGKHILQFVAIKRKDCGEWAIPGGM-----VDPGEKISATLKREFGEEALNSLQKTSAE 187 Query: 137 GREVETTL 144 RE+E L Sbjct: 188 KREIEEKL 195 >4CBQ-A nrPDB Length = 314 Score = 33.5 bits (75), Expect = 0.25, Method: Compositional matrix adjust. Identities = 22/53 (41%), Positives = 28/53 (52%), Gaps = 4/53 (7%) Query: 113 EESYHLTREGGHSHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDL 165 EE+ HLT+ G S ILH DA T+ + LNHP I V+ S V+L Sbjct: 166 EEALHLTKYG--SKVIILHRRDAF--RASKTMQERVLNHPKIEVIWNSELVEL 214 >4FL0-A nrPDB Length = 456 Score = 33.5 bits (75), Expect = 0.26, Method: Compositional matrix adjust. Identities = 27/102 (26%), Positives = 45/102 (44%), Gaps = 23/102 (22%) Query: 288 APRDIVARAIDHEMKRLGA---------------DCMFLDISHKPADFIRQHFPMIYEKL 332 +P I ++D EMK+LG + +F +I+ + + I +H P + +L Sbjct: 16 SPSKIPKASLDFEMKKLGGSTKLVRNVNLEKLKNNYLFPEINRRELEHIEKH-PNV--QL 72 Query: 333 LGLGIDLTQEPVPIVPAAHYTCGGVMVDDHGRTDVEGLYAIG 374 + LG T EP+P +H + HG + VEG G Sbjct: 73 ISLGTGDTTEPIPEQITSHMSNFA-----HGLSTVEGYRGYG 109 >4NEW-A nrPDB Length = 492 Score = 33.1 bits (74), Expect = 0.34, Method: Compositional matrix adjust. Identities = 13/23 (56%), Positives = 19/23 (82%) Query: 355 GGVMVDDHGRTDVEGLYAIGEVS 377 GGV VD++ RT+V +YAIG+V+ Sbjct: 307 GGVQVDEYSRTNVSNIYAIGDVT 329 >5W1J-A nrPDB Length = 584 Score = 32.7 bits (73), Expect = 0.43, Method: Compositional matrix adjust. Identities = 16/30 (53%), Positives = 20/30 (66%) Query: 353 TCGGVMVDDHGRTDVEGLYAIGEVSYTGLH 382 T G V+VDD RT+V +YAIG+VS G Sbjct: 404 TNGRVVVDDEERTNVPNIYAIGDVSNAGYQ 433 >3IHG-A nrPDB Length = 535 Score = 32.3 bits (72), Expect = 0.53, Method: Compositional matrix adjust. Identities = 16/36 (44%), Positives = 25/36 (69%), Gaps = 1/36 (2%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGP 40 +H DVL++G+G GLS A+ LA Q +V+V+ + P Sbjct: 3 DHEVDVLVVGAGLGGLSTAMFLARQGVRVLVVERRP 38 >2GAG-B nrPDB Length = 405 Score = 32.3 bits (72), Expect = 0.58, Method: Compositional matrix adjust. Identities = 19/47 (40%), Positives = 25/47 (53%), Gaps = 3/47 (6%) Query: 2 NTLPEHSCDVLIIGSGAAGLSLALRLADQH---QVIVLSKGPVTEGS 45 N P+ S D +I+G G GL+ A LA H V VL KG + G+ Sbjct: 15 NPEPKKSYDAIIVGGGGHGLATAYFLAKNHGITNVAVLEKGWLAGGN 61 >4NTC-A nrPDB Length = 335 Score = 32.0 bits (71), Expect = 0.61, Method: Compositional matrix adjust. Identities = 18/31 (58%), Positives = 20/31 (64%), Gaps = 1/31 (3%) Query: 10 DVLIIGSGAAGLSLALRLADQ-HQVIVLSKG 39 DVLIIG+G AGLS A LA Q H +V G Sbjct: 16 DVLIIGAGPAGLSTATGLARQLHTAVVFDSG 46 >4RPJ-A nrPDB Length = 399 Score = 31.2 bits (69), Expect = 1.3, Method: Compositional matrix adjust. Identities = 15/41 (36%), Positives = 26/41 (63%), Gaps = 2/41 (4%) Query: 9 CDVLIIGSGAAGLSLALRLADQ--HQVIVLSKGPVTEGSTF 47 D+ ++GSG GL++A R+A Q +V+VL + P G+ + Sbjct: 8 FDLFVVGSGFFGLTIAERVATQLDKRVLVLERRPHIGGNAY 48 >2WOV-A nrPDB Length = 495 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 12/23 (52%), Positives = 18/23 (78%) Query: 355 GGVMVDDHGRTDVEGLYAIGEVS 377 GGV VD+ RT+V +YAIG+++ Sbjct: 310 GGVQVDEFSRTNVPNIYAIGDIT 332 >5JZM-A nrPDB Length = 288 Score = 30.4 bits (67), Expect = 2.3, Method: Compositional matrix adjust. Identities = 14/37 (37%), Positives = 19/37 (51%), Gaps = 2/37 (5%) Query: 171 IGLPGTRRV--VGAWVWNRNKETVETCHAKAVVLATG 205 +GLP ++ V V W +NK + CH A LA G Sbjct: 164 MGLPDSQEVKAVLQWAMKQNKFIISLCHGPAAFLAVG 200 >3AB1-A nrPDB Length = 360 Score = 30.0 bits (66), Expect = 2.7, Method: Compositional matrix adjust. Identities = 11/22 (50%), Positives = 18/22 (81%) Query: 357 VMVDDHGRTDVEGLYAIGEVSY 378 ++VD H +T V+GLYA G+++Y Sbjct: 280 LVVDSHMKTSVDGLYAAGDIAY 301 >3UKH-A nrPDB Length = 519 Score = 30.0 bits (66), Expect = 2.9, Method: Compositional matrix adjust. Identities = 14/25 (56%), Positives = 17/25 (68%) Query: 3 TLPEHSCDVLIIGSGAAGLSLALRL 27 T P+ S DVL+IG+G GL A RL Sbjct: 1 THPDISVDVLVIGAGPTGLGAAKRL 25 >2DKH-A nrPDB Length = 639 Score = 30.0 bits (66), Expect = 3.0, Method: Compositional matrix adjust. Identities = 20/41 (48%), Positives = 24/41 (58%), Gaps = 4/41 (9%) Query: 10 DVLIIGSGAAGLSLALRLA---DQHQVIVLSK-GPVTEGST 46 DVLI+G G AGL+LA +LA D IV K GP+ G Sbjct: 34 DVLIVGCGPAGLTLAAQLAAFPDIRTCIVEQKEGPMELGQA 74 >3MJ4-A nrPDB Length = 397 Score = 29.6 bits (65), Expect = 3.2, Method: Compositional matrix adjust. Identities = 18/47 (38%), Positives = 27/47 (57%), Gaps = 3/47 (6%) Query: 10 DVLIIGSGAAGLSLALRLADQHQ-VIVLSKGPVTEGSTF--YAQGGI 53 D LI+G+G AG LA RLA Q V+++ + P G+ + Y G+ Sbjct: 31 DYLIVGAGFAGSVLAERLASSGQRVLIVDRRPHIGGNAYDCYDDAGV 77 >4H7U-A nrPDB Length = 602 Score = 29.3 bits (64), Expect = 4.8, Method: Compositional matrix adjust. Identities = 17/57 (29%), Positives = 29/57 (50%), Gaps = 2/57 (3%) Query: 10 DVLIIGSGAAGLSLALRLADQH--QVIVLSKGPVTEGSTFYAQGGIAAVFDETDSID 64 D ++ G G AGL +A RL++ +V+V+ GP + + G+A+ ID Sbjct: 42 DFIVAGGGTAGLVVASRLSENSNWKVLVIEAGPSNKDAFVTRVPGLASTLGAGSPID 98 >4HA6-A nrPDB Length = 508 Score = 29.3 bits (64), Expect = 4.8, Method: Compositional matrix adjust. Identities = 13/29 (44%), Positives = 20/29 (68%) Query: 8 SCDVLIIGSGAAGLSLALRLADQHQVIVL 36 +CD++I+G G+AG LA RL++ VL Sbjct: 1 NCDIVIVGGGSAGSLLAARLSEDPDSRVL 29 >1FOH-A nrPDB Length = 664 Score = 28.9 bits (63), Expect = 5.3, Method: Compositional matrix adjust. Identities = 13/24 (54%), Positives = 17/24 (70%) Query: 6 EHSCDVLIIGSGAAGLSLALRLAD 29 E CDVLI+G+G AGL A L++ Sbjct: 5 ESYCDVLIVGAGPAGLMAARVLSE 28 >5U8W-A nrPDB Length = 481 Score = 28.9 bits (63), Expect = 5.5, Method: Compositional matrix adjust. Identities = 12/22 (54%), Positives = 17/22 (77%) Query: 355 GGVMVDDHGRTDVEGLYAIGEV 376 G + VDDH +T V G++AIG+V Sbjct: 302 GFIYVDDHCKTSVPGVFAIGDV 323 >4C3X-A nrPDB Length = 530 Score = 28.9 bits (63), Expect = 5.6, Method: Compositional matrix adjust. Identities = 18/46 (39%), Positives = 24/46 (52%), Gaps = 1/46 (2%) Query: 9 CDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGSTFYAQGGI 53 CDVL++GSG L+ A A Q IVL K G++ Y+ I Sbjct: 28 CDVLVVGSGGGALTGAYTAAAQGLTTIVLEKTDRFGGTSAYSGASI 73 >2Q7V-A nrPDB Length = 325 Score = 28.9 bits (63), Expect = 5.7, Method: Compositional matrix adjust. Identities = 16/40 (40%), Positives = 21/40 (52%), Gaps = 1/40 (2%) Query: 1 MNTLPEHSCDVLIIGSGAAGLSLALRLA-DQHQVIVLSKG 39 M H DV+IIG G AGL+ A+ Q ++L KG Sbjct: 1 MTAPTAHDYDVVIIGGGPAGLTAAIYTGRAQLSTLILEKG 40 >5UWY-A nrPDB Length = 308 Score = 28.9 bits (63), Expect = 6.0, Method: Compositional matrix adjust. Identities = 11/22 (50%), Positives = 17/22 (77%) Query: 355 GGVMVDDHGRTDVEGLYAIGEV 376 G ++ DDH RT + G++AIG+V Sbjct: 256 GWIITDDHMRTSIPGIFAIGDV 277 >5MJK-A nrPDB Length = 327 Score = 28.9 bits (63), Expect = 6.1, Method: Compositional matrix adjust. Identities = 10/23 (43%), Positives = 18/23 (78%) Query: 354 CGGVMVDDHGRTDVEGLYAIGEV 376 G ++ DDH RT++ G++A+G+V Sbjct: 275 AGWIITDDHMRTNIPGIFAVGDV 297 >2GMH-A nrPDB Length = 584 Score = 28.5 bits (62), Expect = 6.9, Method: Compositional matrix adjust. Identities = 15/26 (57%), Positives = 19/26 (73%), Gaps = 3/26 (11%) Query: 10 DVLIIGSGAAGLSLALR---LADQHQ 32 DV+I+G+G AGLS A R LA QH+ Sbjct: 37 DVVIVGAGPAGLSAATRLKQLAAQHE 62 >1XHC-A nrPDB Length = 367 Score = 28.5 bits (62), Expect = 8.8, Method: Compositional matrix adjust. Identities = 12/31 (38%), Positives = 23/31 (74%), Gaps = 1/31 (3%) Query: 352 YTCGGVMVDDHGRTDVEGLYAIGEVS-YTGL 381 +T G+++DD+ RT + +YAIG+ + Y+G+ Sbjct: 245 HTGRGILIDDNFRTSAKDVYAIGDCAEYSGI 275 >4EIQ-A nrPDB Length = 549 Score = 28.1 bits (61), Expect = 9.2, Method: Compositional matrix adjust. Identities = 16/37 (43%), Positives = 22/37 (59%), Gaps = 3/37 (8%) Query: 9 CDVLIIGSGAAGLSLALRLADQ---HQVIVLSKGPVT 42 DVLI+G G G++LAL LA + H V+ G +T Sbjct: 27 TDVLILGGGPVGMALALDLAHRQVGHLVVDAGDGTIT 63 >3R9U-A nrPDB Length = 315 Score = 28.1 bits (61), Expect = 9.4, Method: Compositional matrix adjust. Identities = 29/123 (23%), Positives = 46/123 (37%), Gaps = 29/123 (23%) Query: 10 DVLIIGSGAAGLSLALRL--ADQHQVIVLSK----GPVTEGSTFYAQGGIAAVFDETDSI 63 DV IIG G AGLS L V++ K G +T S G+A V D Sbjct: 6 DVAIIGGGPAGLSAGLYATRGGLKNVVMFEKGMPGGQITSSSEIENYPGVAQVMD----- 60 Query: 64 DSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTREGG 123 + F+A + C+++ + ++ I N + S+ + EGG Sbjct: 61 ------------------GISFMAPWSEQCMRFGLKHEMVGVEQILKNSDGSFTIKLEGG 102 Query: 124 HSH 126 + Sbjct: 103 KTE 105 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1KNR-A nrPDB 812 0.0 5KXJ-A nrPDB 787 0.0 2H88-A nrPDB 581 e-166 4YTP-A nrPDB 578 e-165 3VR8-A nrPDB 570 e-163 2B76-A nrPDB 545 e-155 2BS2-A nrPDB 540 e-154 5XMJ-A nrPDB 537 e-153 2WDR-A nrPDB 517 e-147 2E5V-A nrPDB 461 e-130 1KSU-A nrPDB 337 6e-93 1QO8-A nrPDB 335 3e-92 5ZYN-B nrPDB 327 8e-90 1D4E-A nrPDB 322 2e-88 Sequences not found previously or not previously below threshold: 3GYX-A nrPDB 71 1e-12 4C3X-A nrPDB 51 2e-06 1FEC-A nrPDB 44 2e-04 3ATQ-A nrPDB 43 3e-04 2GMH-A nrPDB 41 0.001 4YKF-A nrPDB 40 0.003 5EZ7-A nrPDB 40 0.003 5JCN-A nrPDB 39 0.004 1FL2-A nrPDB 39 0.005 3IHG-A nrPDB 38 0.010 5MOG-A nrPDB 37 0.019 2Q7V-A nrPDB 37 0.020 5EB4-A nrPDB 37 0.024 5L46-A nrPDB 36 0.034 3SM8-A nrPDB 36 0.035 4P9S-A nrPDB 36 0.039 1GPE-A nrPDB 36 0.040 5MJK-A nrPDB 36 0.048 3CP8-A nrPDB 36 0.066 3GDN-A nrPDB 35 0.074 4H7U-A nrPDB 35 0.075 2WOV-A nrPDB 35 0.075 2GAG-B nrPDB 35 0.076 6N7F-A nrPDB 35 0.096 2BXR-A nrPDB 35 0.11 3RED-A nrPDB 34 0.12 3G05-A nrPDB 34 0.12 3CP2-A nrPDB 34 0.12 2YAU-A nrPDB 34 0.13 1XHC-A nrPDB 34 0.14 1NAA-A nrPDB 34 0.16 4GCM-A nrPDB 34 0.17 5UWY-A nrPDB 34 0.25 4NEW-A nrPDB 33 0.27 1ZDL-A nrPDB 33 0.30 3NK2-X nrPDB 33 0.32 2JB2-A nrPDB 33 0.32 4NTC-A nrPDB 33 0.39 1O5W-A nrPDB 33 0.41 3LAD-A nrPDB 32 0.44 4OVI-A nrPDB 32 0.45 5KOX-A nrPDB 32 0.46 4ZCC-A nrPDB 32 0.46 5X1Y-B nrPDB 32 0.48 4AP1-A nrPDB 32 0.49 1F8S-A nrPDB 32 0.53 1RP0-A nrPDB 32 0.56 4DX0-A nrPDB 32 0.59 3UKH-A nrPDB 32 0.65 5NWK-A nrPDB 32 0.68 5BR7-A nrPDB 32 0.70 4C5O-A nrPDB 32 0.70 3KKJ-A nrPDB 32 0.73 3R9U-A nrPDB 32 0.73 1YQZ-A nrPDB 32 0.77 5Y77-A nrPDB 32 0.78 2EQ6-A nrPDB 32 0.80 4UIR-A nrPDB 32 0.81 4RPJ-A nrPDB 32 0.85 3OC4-A nrPDB 32 0.86 3BI4-A nrPDB 32 0.90 5U8W-A nrPDB 32 0.91 4N9X-A nrPDB 32 0.91 3RHA-A nrPDB 32 0.97 5EQD-A nrPDB 31 0.99 2YQU-A nrPDB 31 1.0 5W1J-A nrPDB 31 1.0 2R9Z-A nrPDB 31 1.2 4IA5-A nrPDB 31 1.2 3O0H-A nrPDB 31 1.3 2CVJ-A nrPDB 31 1.4 3BHF-A nrPDB 31 1.5 3KVE-A nrPDB 31 1.6 4B1B-A nrPDB 31 2.0 3Q6J-A nrPDB 31 2.0 4CBQ-A nrPDB 31 2.1 2NVK-X nrPDB 31 2.2 2RGJ-A nrPDB 30 2.2 4IWB-A nrPDB 30 2.3 1ORY-A nrPDB 30 2.3 4YNU-A nrPDB 30 2.4 5TNX-A nrPDB 30 2.4 4FOI-A nrPDB 30 2.5 3AXY-C nrPDB 30 2.5 5TR3-A nrPDB 30 2.5 4KQV-A nrPDB 30 2.6 6BZ0-A nrPDB 30 2.7 3K9D-A nrPDB 30 2.7 1V59-A nrPDB 30 2.7 3FPZ-A nrPDB 30 2.8 2BC1-A nrPDB 30 2.8 1ZOV-A nrPDB 30 2.9 1FOH-A nrPDB 30 3.0 4EMJ-A nrPDB 30 3.4 1REO-A nrPDB 30 3.4 3O04-A nrPDB 30 3.7 2VVL-G nrPDB 29 3.8 5J5Z-A nrPDB 29 3.9 4LS7-A nrPDB 29 4.0 3KLJ-A nrPDB 29 4.1 6AON-A nrPDB 29 4.5 2ZXH-A nrPDB 29 4.6 3URH-A nrPDB 29 4.6 4YWO-A nrPDB 29 4.7 3RP7-A nrPDB 29 5.0 4HA6-A nrPDB 29 5.2 4Y4M-A nrPDB 29 5.9 2W2A-A nrPDB 29 6.3 1PJ5-A nrPDB 29 6.5 4JDR-A nrPDB 29 6.6 6J0Z-C nrPDB 29 6.8 5UTH-A nrPDB 29 6.9 2A87-A nrPDB 29 7.2 1ZEJ-A nrPDB 29 7.7 6BPY-A nrPDB 29 8.0 5U63-A nrPDB 28 9.0 2VHY-A nrPDB 28 9.8 6GAS-A nrPDB 28 10.0 >1KNR-A nrPDB Length = 540 Score = 812 bits (2097), Expect = 0.0, Method: Composition-based stats. Identities = 538/540 (99%), Positives = 539/540 (99%) Query: 1 MNTLPEHSCDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDET 60 MNTLPEHSCDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDET Sbjct: 1 MNTLPEHSCDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDET 60 Query: 61 DSIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTR 120 DSIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTR Sbjct: 61 DSIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTR 120 Query: 121 EGGHSHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLPGTRRVV 180 EGGHSHRRILHAADATGREVETTLVSKALNHPNIRVLER+NAVDLIVSDKIGLPGTRRVV Sbjct: 121 EGGHSHRRILHAADATGREVETTLVSKALNHPNIRVLERTNAVDLIVSDKIGLPGTRRVV 180 Query: 181 GAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVANLEF 240 GAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVANLEF Sbjct: 181 GAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVANLEF 240 Query: 241 NQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERGELAPRDIVARAIDHE 300 NQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERGELAPRDIVARAIDHE Sbjct: 241 NQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERGELAPRDIVARAIDHE 300 Query: 301 MKRLGADCMFLDISHKPADFIRQHFPMIYEKLLGLGIDLTQEPVPIVPAAHYTCGGVMVD 360 MKRLGADCMFLDISHKPADFIRQHFPMIYEKLLGLGIDLTQEPVPIVPAAHYTCGGVMVD Sbjct: 301 MKRLGADCMFLDISHKPADFIRQHFPMIYEKLLGLGIDLTQEPVPIVPAAHYTCGGVMVD 360 Query: 361 DHGRTDVEGLYAIGEVSYTGLHGANRMASNSLLECLVYGWSAAEDITRRMPYAHDISTLP 420 DHGRTDVEGLYAIGEVSYTGLHGAN MASNSLLECLVYGWSAAEDITRRMPYAHDISTLP Sbjct: 361 DHGRTDVEGLYAIGEVSYTGLHGANLMASNSLLECLVYGWSAAEDITRRMPYAHDISTLP 420 Query: 421 PWDESRVENPDERVVIQHNWHELRLFMWDYVGIVRTTKRLERALRRITMLQQEIDEYYAH 480 PWDESRVENPDERVVIQHNWHELRLFMWDYVGIVRTTKRLERALRRITMLQQEIDEYYAH Sbjct: 421 PWDESRVENPDERVVIQHNWHELRLFMWDYVGIVRTTKRLERALRRITMLQQEIDEYYAH 480 Query: 481 FRVSNNLLELRNLVQVAELIVRCAMMRKESRGLHFTLDYPELLTHSGPSILSPGNHYINR 540 FRVSNNLLELRNLVQVAELIVRCAMMRKESRGLHFTLDYPELLTHSGPSILSPGNHYINR Sbjct: 481 FRVSNNLLELRNLVQVAELIVRCAMMRKESRGLHFTLDYPELLTHSGPSILSPGNHYINR 540 >5KXJ-A nrPDB Length = 557 Score = 787 bits (2033), Expect = 0.0, Method: Composition-based stats. Identities = 485/540 (89%), Positives = 513/540 (95%) Query: 1 MNTLPEHSCDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDET 60 M T PE SCDVLIIGSGAAGLSLALRLA++H+VIVLSKGPV+EGSTFYAQGGIAAVFDET Sbjct: 1 MMTTPELSCDVLIIGSGAAGLSLALRLAEKHKVIVLSKGPVSEGSTFYAQGGIAAVFDET 60 Query: 61 DSIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTR 120 DSI SHVEDTLIAGAGICDRHAVEFVASNAR+CVQWLIDQGVLFDTH+QPNG+ESYHLTR Sbjct: 61 DSIASHVEDTLIAGAGICDRHAVEFVASNARTCVQWLIDQGVLFDTHVQPNGKESYHLTR 120 Query: 121 EGGHSHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLPGTRRVV 180 EGGHSHRRILHAADATG+EVETTLVS+A NHPNI+VLERSNAVDLI+SDK+GLPG RRVV Sbjct: 121 EGGHSHRRILHAADATGKEVETTLVSRAQNHPNIQVLERSNAVDLIISDKMGLPGPRRVV 180 Query: 181 GAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVANLEF 240 GAW+WNRNKE VETCHAK+VVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVANLEF Sbjct: 181 GAWIWNRNKEWVETCHAKSVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVANLEF 240 Query: 241 NQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERGELAPRDIVARAIDHE 300 NQFHPTALYHPQARNFLLTEALRGEGAYLKRPDG+RFMPD DERGELAPRDIVARAIDHE Sbjct: 241 NQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGSRFMPDVDERGELAPRDIVARAIDHE 300 Query: 301 MKRLGADCMFLDISHKPADFIRQHFPMIYEKLLGLGIDLTQEPVPIVPAAHYTCGGVMVD 360 MK+LGADCMFLDISHKP DF+RQHFPMIY KLL LG+DLT+EP+P+VPAAHYTCGGV+VD Sbjct: 301 MKQLGADCMFLDISHKPDDFVRQHFPMIYAKLLDLGMDLTKEPIPVVPAAHYTCGGVVVD 360 Query: 361 DHGRTDVEGLYAIGEVSYTGLHGANRMASNSLLECLVYGWSAAEDITRRMPYAHDISTLP 420 D+GRTDV+GLYAIGEVSYTGLHGANRMASNSLLECLVYGWSAA DI RRMP H + LP Sbjct: 361 DYGRTDVDGLYAIGEVSYTGLHGANRMASNSLLECLVYGWSAAMDIDRRMPSVHSVDALP 420 Query: 421 PWDESRVENPDERVVIQHNWHELRLFMWDYVGIVRTTKRLERALRRITMLQQEIDEYYAH 480 WDESRVEN DERVVIQHNWHELRL MWDYVGIVRTTKRLERALRRITMLQQEIDEYYA+ Sbjct: 421 AWDESRVENADERVVIQHNWHELRLLMWDYVGIVRTTKRLERALRRITMLQQEIDEYYAN 480 Query: 481 FRVSNNLLELRNLVQVAELIVRCAMMRKESRGLHFTLDYPELLTHSGPSILSPGNHYINR 540 FRVSNNLLELRNLVQVAELIVRCAMMRKESRGLHFTLDYP+ L SGPSILSP +INR Sbjct: 481 FRVSNNLLELRNLVQVAELIVRCAMMRKESRGLHFTLDYPQQLAESGPSILSPLTPHINR 540 >2H88-A nrPDB Length = 621 Score = 581 bits (1498), Expect = e-166, Method: Composition-based stats. Identities = 162/553 (29%), Positives = 254/553 (45%), Gaps = 51/553 (9%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGSTFYAQGGIAAVFD--ETDS 62 +H D +++G+G AGL A L++ ++K T T AQGGI A E D+ Sbjct: 16 DHEFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEDDN 75 Query: 63 IDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDT------HIQPNGEESY 116 H DT+ + D+ A+ ++ A + V L + G+ F + + G +S Sbjct: 76 WRWHFYDTVKGSDWLGDQDAIHYMTEQAPAAVIELENYGMPFSRTEEGKIYQRAFGGQSL 135 Query: 117 HLTREGGHSHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLPGT 176 + GG +H R AD TG + TL ++L + +E A+DL++ + Sbjct: 136 QFGK-GGQAH-RCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYF-ALDLLMENG------ 186 Query: 177 RRVVGAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVA 236 G T+ AK V+ATGG + Y T+ S+GDG AM RAG Sbjct: 187 -ECRGVIALCIEDGTIHRFRAKNTVIATGGYGRTYFSCTSAHTSTGDGTAMVTRAGLPCQ 245 Query: 237 NLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERG-ELAPRDIVAR 295 +LEF QFHPT +Y L+TE RGEG L G RFM + +LA RD+V+R Sbjct: 246 DLEFVQFHPTGIY---GAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSR 302 Query: 296 AIDHEMK-----RLGADCMFLDISHKPADFIRQHFPMIYEK-LLGLGIDLTQEPVPIVPA 349 ++ E++ D ++L + H P + P I E ++ G+D+T+EP+P++P Sbjct: 303 SMTIEIREGRGCGPEKDHVYLQLHHLPPQQLATRLPGISETAMIFAGVDVTKEPIPVLPT 362 Query: 350 AHYTCGGVMVDDHGRTD---------VEGLYAIGEVSYTGLHGANRMASNSLLECLVYGW 400 HY GG+ + G+ V GLYA GE + +HGANR+ +NSLL+ +V+G Sbjct: 363 VHYNMGGIPTNYKGQVITHVNGEDKVVPGLYACGEAASASVHGANRLGANSLLDLVVFGR 422 Query: 401 SAAEDITRRMPYAHDISTLPP-WDESRVENPDE------RVVIQHNWHELRLFMWDYVGI 453 + A I + ++ P E V N D+ + ++ M + + Sbjct: 423 ACALTIAETCKPGEPVPSIKPNAGEESVANLDKLRFADGTIRTSEARLNMQKTMQSHAAV 482 Query: 454 VRTTKRLERALRRITMLQQEIDEYYAHFR--VSN----NLLELRNLVQVAELIVRCAMMR 507 RT L+ +++ + +++ R V N LEL+NL+ A + A R Sbjct: 483 FRTGSILQEGCEKLSQIYRDLAHLKTFDRGIVWNTDLVETLELQNLMLCALQTIYGAEAR 542 Query: 508 KESRGLHFTLDYP 520 KESRG H DY Sbjct: 543 KESRGAHAREDYK 555 >4YTP-A nrPDB Length = 664 Score = 578 bits (1489), Expect = e-165, Method: Composition-based stats. Identities = 161/558 (28%), Positives = 253/558 (45%), Gaps = 51/558 (9%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGSTFYAQGGIAAVFD--ETDS 62 +H D +++G+G AGL A L++ ++K T T AQGGI A E D+ Sbjct: 59 DHEFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDN 118 Query: 63 IDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDT------HIQPNGEESY 116 H DT+ + D+ A+ ++ A + V L + G+ F + + G +S Sbjct: 119 WRWHFYDTVKGSDWLGDQDAIHYMTEQAPASVVELENYGMPFSRTEDGKIYQRAFGGQSL 178 Query: 117 HLTREGGHSHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLPGT 176 + GG +H R AD TG + TL ++L + +E A+DL++ + Sbjct: 179 KFGK-GGQAH-RCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYF-ALDLLMENG------ 229 Query: 177 RRVVGAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVA 236 G ++ A+ V+ATGG + Y T+ S+GDG AM RAG Sbjct: 230 -ECRGVIALCIEDGSIHRIRARNTVVATGGYGRTYFSCTSAHTSTGDGTAMVTRAGLPCQ 288 Query: 237 NLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERG-ELAPRDIVAR 295 +LEF QFHPT +Y L+TE RGEG L G RFM + +LA RD+V+R Sbjct: 289 DLEFVQFHPTGIY---GAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSR 345 Query: 296 AIDHEMK-----RLGADCMFLDISHKPADFIRQHFPMIYEK-LLGLGIDLTQEPVPIVPA 349 ++ E++ D ++L + H P + + P I E ++ G+D+T+EP+P++P Sbjct: 346 SMTLEIREGRGCGPEKDHVYLQLHHLPPEQLAVRLPGISETAMIFAGVDVTKEPIPVLPT 405 Query: 350 AHYTCGGVMVDDHGRT---------DVEGLYAIGEVSYTGLHGANRMASNSLLECLVYGW 400 HY GG+ + G+ V GLYA GE + +HGANR+ +NSLL+ +V+G Sbjct: 406 VHYNMGGIPTNYKGQVLRHVNGQDQVVPGLYACGEAACASVHGANRLGANSLLDLVVFGR 465 Query: 401 SAAEDITRRMPYAHDISTLPP-WDESRVENPDERVVIQHNWH------ELRLFMWDYVGI 453 + A I + ++ P E V N D+ ++ M + + Sbjct: 466 ACALSIAESCRPGDKVPSIKPNAGEESVMNLDKLRFANGTIRTSELRLSMQKSMQSHAAV 525 Query: 454 VRTTKRLERALRRITMLQQEIDEYYAHFR--VSN----NLLELRNLVQVAELIVRCAMMR 507 R L+ +I L ++ R V N LEL+NL+ A + A R Sbjct: 526 FRVGSVLQEGCEKILRLYGDLQHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEAR 585 Query: 508 KESRGLHFTLDYPELLTH 525 KESRG H D+ E + Sbjct: 586 KESRGAHAREDFKERVDE 603 >3VR8-A nrPDB Length = 645 Score = 570 bits (1468), Expect = e-163, Method: Composition-based stats. Identities = 171/555 (30%), Positives = 262/555 (47%), Gaps = 52/555 (9%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGSTFYAQGGIAAVFDET--DS 62 +H+ DV+IIG+G AGL A+ L + + V++K T T AQGGI A D Sbjct: 39 DHAYDVVIIGAGGAGLRAAMGLGEAGFKTAVVTKMFPTRSHTTAAQGGINAALGSMNPDD 98 Query: 63 IDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDT------HIQPNGEESY 116 H DT + D++A+ ++ NA V L + G+ F + + G +S Sbjct: 99 WKWHFYDTAKGSDWLGDQNAMHYLTRNAVEAVTELENFGMPFSRTPEGKIYQRSFGGQSN 158 Query: 117 HLTREGGHSHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLPGT 176 + + G +R AD TG + TL +L +E A+DL++ Sbjct: 159 NYGKGG--VAKRTCCVADRTGHSMLHTLYGNSLRCHCTFFIEYF-ALDLLMDKG------ 209 Query: 177 RRVVGAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVA 236 R VG T+ +K ++ATGG + Y T +++GDG A+A RAG + Sbjct: 210 -RCVGVIALCLEDGTIHRFRSKRTIVATGGYGRAYFSCTTAHMNTGDGTALATRAGIALE 268 Query: 237 NLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERG-ELAPRDIVAR 295 +LEF QFHPT +Y L+TE RGEG +L +G RFM + + +LA RD+V+R Sbjct: 269 DLEFIQFHPTGIY---GVGCLITEGSRGEGGFLVNSEGERFMERYAPKAKDLASRDVVSR 325 Query: 296 AIDHEMK-----RLGADCMFLDISHKPADFIRQHFPMIYEKL-LGLGIDLTQEPVPIVPA 349 A E+ D ++L + H PA+ + Q P I E + G+D+T+EP+P++P Sbjct: 326 AETIEIMEGRGVGPEKDHIYLQLHHLPAEQLHQRLPGISETAKIFAGVDVTKEPIPVIPT 385 Query: 350 AHYTCGGVMVDDH----------GRTDVEGLYAIGEVSYTGLHGANRMASNSLLECLVYG 399 HY GG+ + G V GLYA GE + +HGANR+ +NSLL+ +V+G Sbjct: 386 VHYNMGGIPTNYKAQVIKYTKEGGDKIVPGLYACGECACHSVHGANRLGANSLLDAVVFG 445 Query: 400 WSAAEDITRRMPYAHDISTLPP-WDESRVENPDERVVIQHN--WHELRL----FMWDYVG 452 + + +I + I LP E + N D + ELRL M + G Sbjct: 446 RACSINIKEELKPDEKIPELPEGAGEESIANLDAVRYANGDVPTAELRLTMQKTMQKHAG 505 Query: 453 IVRTTKRLERALRRITMLQQEIDEYYAHFR--VSN----NLLELRNLVQVAELIVRCAMM 506 + R L ++++ L +E+ R + N LEL+NL+ A + A Sbjct: 506 VFRRGDILAEGVKKMMDLSKELKRLKTTDRSLIWNSDLTESLELQNLMLNATQTIVAAEN 565 Query: 507 RKESRGLHFTLDYPE 521 RKESRG H D+P+ Sbjct: 566 RKESRGAHARDDFPK 580 >2B76-A nrPDB Length = 602 Score = 545 bits (1403), Expect = e-155, Method: Composition-based stats. Identities = 170/524 (32%), Positives = 262/524 (50%), Gaps = 55/524 (10%) Query: 32 QVIVLSKGPVTEGSTFYAQGGIAAVFDETDSIDSHVEDTLIAGAGICDRHAVEFVASNAR 91 ++ ++SK T AQGG AAV + DS + H DT+ G +C++ V++ + Sbjct: 32 KIALISKVYPMRSHTVAAQGGSAAVAQDHDSFEYHFHDTVAGGDWLCEQDVVDYFVHHCP 91 Query: 92 SCVQWLIDQGVLFDTHIQPNGEESYHLTREGGHSHRRILHAADATGREVETTLVSKALNH 151 + + L G + +P+G S ++ R GG R AAD TG + TL +L Sbjct: 92 TEMTQLELWGCPWSR--RPDG--SVNVRRFGGMKIERTWFAADKTGFHMLHTLFQTSLQF 147 Query: 152 PNIRVLERSNAVDLIVSDKIGLPGTRRVVGAWVWNRNKETVETCHAKAVVLATGGASKVY 211 P I+ + +D++V D V G N + T+ A AVV+ATGGA +VY Sbjct: 148 PQIQRFDEHFVLDILVDDG-------HVRGLVAMNMMEGTLVQIRANAVVMATGGAGRVY 200 Query: 212 QYTTNPDISSGDGIAMAWRAGCRVANLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKR 271 +Y TN I +GDG+ MA G + ++EF Q+HPT L L+TE RGEG L Sbjct: 201 RYNTNGGIVTGDGMGMALSHGVPLRDMEFVQYHPTGL---PGSGILMTEGCRGEGGILVN 257 Query: 272 PDGTRFMPDF------------DERGELAPRDIVARAIDHEMKRLG------ADCMFLDI 313 +G R++ D+ ++ EL PRD V++A HE ++ D ++LD+ Sbjct: 258 KNGYRYLQDYGMGPETPLGEPKNKYMELGPRDKVSQAFWHEWRKGNTISTPRGDVVYLDL 317 Query: 314 SHKPADFIRQHFPMIYEKL-LGLGIDLTQEPVPIVPAAHYTCGGVMVDDHGRTDVEGLYA 372 H + + P I E +G+D +EP+P+ P AHYT GG+ D + T ++GL+A Sbjct: 318 RHLGEKKLHERLPFICELAKAYVGVDPVKEPIPVRPTAHYTMGGIETDQNCETRIKGLFA 377 Query: 373 IGEVSYTGLHGANRMASNSLLECLVYGWSAAEDITRRMPYAHDISTLP-PWDESRVENPD 431 +GE S GLHGANR+ SNSL E +V+G A E T R A + + + VE Sbjct: 378 VGECSSVGLHGANRLGSNSLAELVVFGRLAGEQATERAATAGNGNEAAIEAQAAGVEQRL 437 Query: 432 ERVVIQ---HNWHELR----LFMWDYVGIVRTTKRLERALRRITMLQQEIDEYYAHFRVS 484 + +V Q NW ++R L M + GI RT + +++ + ++ LQ+ + R++ Sbjct: 438 KDLVNQDGGENWAKIRDEMGLAMEEGCGIYRTPELMQKTIDKLAELQER----FKRVRIT 493 Query: 485 NN----------LLELRNLVQVAELIVRCAMMRKESRGLHFTLD 518 + +EL + + VAE + AM RKESRG H LD Sbjct: 494 DTSSVFNTDLLYTIELGHGLNVAECMAHSAMARKESRGAHQRLD 537 >2BS2-A nrPDB Length = 660 Score = 540 bits (1391), Expect = e-154, Method: Composition-based stats. Identities = 162/565 (28%), Positives = 250/565 (44%), Gaps = 68/565 (12%) Query: 9 CDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGSTFYAQGGIAAVFD-----ETDS 62 CD L+IG G AGL A+ + IVLS PV + AQGG+ A + D+ Sbjct: 6 CDSLVIGGGLAGLRAAVATQQKGLSTIVLSLIPVKRSHSAAAQGGMQASLGNSKMSDGDN 65 Query: 63 IDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLF------------DTHIQP 110 D H DT+ CD+ + A ++ L GV + + Sbjct: 66 EDLHFMDTVKGSDWGCDQKVARMFVNTAPKAIRELAAWGVPWTRIHKGDRMAIINAQKTT 125 Query: 111 NGEES-----YHLTREGGHSHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDL 165 EE H GG R + ADATG + + ++ L + + +R A+ L Sbjct: 126 ITEEDFRHGLIHSRDFGGTKKWRTCYTADATGHTMLFAVANECLKL-GVSIQDRKEAIAL 184 Query: 166 IVSDKIGLPGTRRVVGAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGI 225 I D + GA V + + AK ++ATGG ++Y+ TTN + G G Sbjct: 185 IHQDG-------KCYGAVVRDLVTGDIIAYVAKGTLIATGGYGRIYKNTTNAVVCEGTGT 237 Query: 226 AMAWRAG-CRVANLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDE- 283 A+A G ++ N+E QFHPT L+ LLTE RG+G L+ DG RFMPD++ Sbjct: 238 AIALETGIAQLGNMEAVQFHPTPLF---PSGILLTEGCRGDGGILRDVDGHRFMPDYEPE 294 Query: 284 RGELAPRDIVAR-AIDHEMKRLG-----ADCMFLDISHKPADFIRQHFPMIYEKLLGL-G 336 + ELA RD+V+R I+H K G ++LDIS I + + E G Sbjct: 295 KKELASRDVVSRRMIEHIRKGKGVQSPYGQHLWLDISILGRKHIETNLRDVQEICEYFAG 354 Query: 337 IDLTQEPVPIVPAAHYTCGGVMVDDHGRTDVEGLYAIGEVSYTGLHGANRMASNSLLECL 396 ID ++ P++P HY+ GG+ D G ++GL++ GE + +HG NR+ NS+ E + Sbjct: 355 IDPAEKWAPVLPMQHYSMGGIRTDYRGEAKLKGLFSAGEAACWDMHGFNRLGGNSVSEAV 414 Query: 397 VYGWSAAEDITRRMPYAHD----------ISTLPPWDESRVENPDERVVIQHNWHELRLF 446 V G E + + +S VE+ V + + ++ Sbjct: 415 VAGMIVGEYFAEHCANTQVDLETKTLEKFVKGQEAYMKSLVESKGTEDVFKIK-NRMKDV 473 Query: 447 MWDYVGIVRTTKRLERALRRITMLQQEIDEYYAHFRVSNNLL----ELRN------LVQV 496 M D VGI R LE+A++ + +E+ + + + N L EL +++V Sbjct: 474 MDDNVGIFRDGPHLEKAVKEL----EELYKKSKNVGIKNKRLHANPELEEAYRVPMMLKV 529 Query: 497 AELIVRCAMMRKESRGLHFTLDYPE 521 A + + A+ R ESRG H DYP+ Sbjct: 530 ALCVAKGALDRTESRGAHNREDYPK 554 >5XMJ-A nrPDB Length = 627 Score = 537 bits (1382), Expect = e-153, Method: Composition-based stats. Identities = 154/567 (27%), Positives = 243/567 (42%), Gaps = 70/567 (12%) Query: 9 CDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGSTFYAQGGI-----AAVFDETDS 62 DVL IG AG +A+ + + I+LS P + AQGG+ A+ + DS Sbjct: 6 TDVLCIGGALAGERVAVEASMAGLKTIMLSLVPPRRSHSSAAQGGMQAALGNAIMGDGDS 65 Query: 63 IDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVL-----------------FD 105 D H DT+ CD+ A A ++ + GV F+ Sbjct: 66 PDVHFADTVKGSDWGCDQEVARIFADTAPIVMREVAHWGVPWNRVVPGKHTYYKGGKPFE 125 Query: 106 THIQPNGEESYHLTREGGHSHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDL 165 + H GG + R + AD TGR V TL +K L + + V +R A L Sbjct: 126 AEEKAEKAGLIHARAFGGTAAWRTCYTADGTGRSVLNTLDTKCLQY-GVTVHDRMQAEAL 184 Query: 166 IVSDKIGLPGTRRVVGAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGI 225 I +G + A + ++ATGG ++Y+ TTN I G G Sbjct: 185 IHDGGN-------CLGCIARCLRTGELVAYLATSTLIATGGYGRIYKATTNAVICDGGGQ 237 Query: 226 AMAWRAG-CRVANLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDE- 283 +A G + N+E QFHPT + L+TE RG+G L + RFMPD++ Sbjct: 238 IIALDTGLVPMGNMEAVQFHPTGTV---PTDILVTEGCRGDGGTLLDVNQYRFMPDYEPD 294 Query: 284 RGELAPRDIVARAIDHEMKR------LGADCMFLDISHKPADFIRQHFPMIYEKLLGL-G 336 + +LA RD+V+R + M++ D ++LDI H I +Y+ G Sbjct: 295 KAQLASRDVVSRRMTEHMRKGLGVKSPYGDHLWLDIRHLGEKHITTKLREVYDICTNFLG 354 Query: 337 IDLTQEPVPIVPAAHYTCGGVMVDDHGRT-DVEGLYAIGEVSYTGLHGANRMASNSLLEC 395 ++ + +P+ P HY+ GGV + G ++GL++ GE + +HG NR+ NSL E Sbjct: 355 VNPIHQLIPVRPTHHYSMGGVRTNRDGAAYGLKGLFSAGESACWDMHGFNRLGGNSLAET 414 Query: 396 LVYGWSAAEDITRRMPYAHDISTLPPWDESRVENPDERV-----------VIQHNWHELR 444 +V G E + A P + VE+ ++V + N ++R Sbjct: 415 VVAGRYIGERMVEFTKGA-----TPSFGMQYVEDAHKKVQERITDIVTGRKGKENTFKIR 469 Query: 445 LFMWD----YVGIVRTTKRLERALRRITMLQ---QEIDEYYAHFRVSNNL---LELRNLV 494 M D VGI R L++A+ ++ L Q+I A ++ L L +R ++ Sbjct: 470 DEMHDIMMEGVGIFRNGTDLQKAVNKLEELYDRSQKISLSSACKGMNPELSTALRIRGML 529 Query: 495 QVAELIVRCAMMRKESRGLHFTLDYPE 521 ++A+ A+ R ESRG H D+PE Sbjct: 530 KLAQCTAYGALDRTESRGAHTREDFPE 556 >2WDR-A nrPDB Length = 588 Score = 517 bits (1332), Expect = e-147, Method: Composition-based stats. Identities = 167/566 (29%), Positives = 255/566 (45%), Gaps = 65/566 (11%) Query: 2 NTLPEHSCDVLIIGSGAAGLSLALRLADQHQVI-VLSKGPVTEGSTFYAQGGIAAVFDET 60 LP D ++IG+G AG+ AL+++ Q +LSK T T AQGGI T Sbjct: 1 MKLPVREFDAVVIGAGGAGMRAALQISQSGQTCALLSKVFPTRSHTVSAQGGITVALGNT 60 Query: 61 --DSIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDT------HIQPNG 112 D+ + H+ DT+ I D+ A+E++ + L G+ F + +P G Sbjct: 61 HEDNWEWHMYDTVKGSDYIGDQDAIEYMCKTGPEAILELEHMGLPFSRLDDGRIYQRPFG 120 Query: 113 EESYHLTREGGHSHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIG 172 +S + GG R AAD TG + TL + L + + A+DL+ + Sbjct: 121 GQSKN---FGGEQAARTAAAADRTGHALLHTLYQQNLKNHTT-IFSEWYALDLVKNQDGA 176 Query: 173 LPGTRRVVGAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIAMAWRAG 232 VVG V A+A VLATGGA ++YQ TTN I++GDG+ MA RAG Sbjct: 177 ------VVGCTALCIETGEVVYFKARATVLATGGAGRIYQSTTNAHINTGDGVGMAIRAG 230 Query: 233 CRVANLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERG-ELAPRD 291 V ++E QFHPT + L+TE RGEG YL G RFM + +LA RD Sbjct: 231 VPVQDMEMWQFHPTGI---AGAGVLVTEGCRGEGGYLLNKHGERFMERYAPNAKDLAGRD 287 Query: 292 IVARAIDHEMK------RLGADCMFLDISHKPADFIRQHFPMIYEKLLGLG-IDLTQEPV 344 +VAR+I E++ L + H + + P I E +D +EP+ Sbjct: 288 VVARSIMIEIREGRGCDGPWGPHAKLKLDHLGKEVLESRLPGILELSRTFAHVDPVKEPI 347 Query: 345 PIVPAAHYTCGGVMV---------DDHGR-TDVEGLYAIGEVSYTGLHGANRMASNSLLE 394 P++P HY GG+ ++ G V GL+A+GE++ +HGANR+ NSLL+ Sbjct: 348 PVIPTCHYMMGGIPTKVTGQALTVNEKGEDVVVPGLFAVGEIACVSVHGANRLGGNSLLD 407 Query: 395 CLVYGWSAAEDITRRMPYAHDISTLPPWDESRVENP-------------DERVVIQHNWH 441 +V+G +A + + + L ES VE ++ V I+ Sbjct: 408 LVVFGRAAGLHLQESIA---EQGALRDASESDVEASLDRLNRWNNNRNGEDPVAIRKALQ 464 Query: 442 ELRLFMWDYVGIVRTTKRLERALRRITMLQQ-----EIDEYYAHFRVSN-NLLELRNLVQ 495 E M + R + + L ++ ++++ +D+ + F LEL NL++ Sbjct: 465 EC---MQHNFSVFREGDAMAKGLEQLKVIRERLKNARLDDTSSEFNTQRVECLELDNLME 521 Query: 496 VAELIVRCAMMRKESRGLHFTLDYPE 521 A A R ESRG H D+P+ Sbjct: 522 TAYATAVSANFRTESRGAHSRFDFPD 547 >2E5V-A nrPDB Length = 472 Score = 461 bits (1185), Expect = e-130, Method: Composition-based stats. Identities = 192/520 (36%), Positives = 276/520 (53%), Gaps = 75/520 (14%) Query: 11 VLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDETDSIDSHVEDT 70 + IIGSG AGLS + L + + L + GST A+GG+AA DS + H +DT Sbjct: 2 IYIIGSGIAGLSAGVALRRAGKKVTLISKRIDGGSTPIAKGGVAASVGSDDSPELHAQDT 61 Query: 71 LIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTREGGHSHRRIL 130 + G G+CD V +V S A++ ++ G F+ L EGGH+ RR+L Sbjct: 62 IRVGDGLCDVKTVNYVTSEAKNVIETFESWGFEFEED----------LRLEGGHTKRRVL 111 Query: 131 HAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLPGTRRVVGAWVWNRNKE 190 H D TGRE+ L+ K I ++E V++ V D +V G R Sbjct: 112 HRTDETGREIFNFLL-KLAREEGIPIIED-RLVEIRVKDG-------KVTGFVTEKR--G 160 Query: 191 TVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVANLEFNQFHPTALYH 250 VE +VLATGG S +Y+Y++ + GDG+A+A++AG +A++EF QFHPT + Sbjct: 161 LVEDV--DKLVLATGGYSYLYEYSSTQSTNIGDGMAIAFKAGTILADMEFVQFHPT-VTS 217 Query: 251 PQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERGELAPRDIVARAIDHEMKRLGADCMF 310 FLLTE LRGEGA + +G RF+ ++D+RGELAPRDI++RAI EM L +F Sbjct: 218 LDGEVFLLTETLRGEGAQIINENGERFLFNYDKRGELAPRDILSRAIYIEM--LKGHKVF 275 Query: 311 LDISHKPADFIRQHFPMIYEKLLGLGIDLTQEPVPIVPAAHYTCGGVMVDDHGRTDVEGL 370 +D+S K DF R+ FP++ + L G + + +PI PAAH+ GG+ V+ G +++ L Sbjct: 276 IDLS-KIEDFERK-FPVVAKYLARHGHNY-KVKIPIFPAAHFVDGGIRVNIRGESNIVNL 332 Query: 371 YAIGEVSYTGLHGANRMASNSLLECLVYGWSAAEDITRRMPYAHDISTLPPWDESRVE-- 428 YAIGEVS +GLHGANR+ASNSLLE LV+G + LP + +S E Sbjct: 333 YAIGEVSDSGLHGANRLASNSLLEGLVFGIN-----------------LPRYVDSSWEGI 375 Query: 429 NPDERVV----IQHN----WHELRLFMWDYVGIVRTTKRLERALRRITMLQQEIDEYYAH 480 + D+ +V I N E+R W+ VGI+R ++L +A+ + Q Sbjct: 376 STDDGIVHSVRISGNKTLSLKEIRRINWENVGIIRNEEKLVKAINTYSSSTQ-------- 427 Query: 481 FRVSNNLLELRNLVQVAELIVRCAMMRKESRGLHFTLDYP 520 N ++ L A +RKESRG HF DYP Sbjct: 428 -----------NEAIISYLTALAAEIRKESRGNHFREDYP 456 >1KSU-A nrPDB Length = 571 Score = 337 bits (865), Expect = 6e-93, Method: Composition-based stats. Identities = 116/458 (25%), Positives = 185/458 (40%), Gaps = 94/458 (20%) Query: 21 LSLALRLADQH-QVIVLSKGPVTEGSTFYAQGGIAAVFDE-------TDSIDSHVEDTLI 72 S A+ D +VI++ K PV G+ A GG+ A + + TDS + EDT+ Sbjct: 139 FSAAISATDSGAKVILIEKEPVIGGNAKLAAGGMNAAWTDQQKAKKITDSPELMFEDTMK 198 Query: 73 AGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTREGGHSHRRILHA 132 G I D V+ ++S+++ V W+ G T + G S + +HR A Sbjct: 199 GGQNINDPALVKVLSSHSKDSVDWMTAMGADL-TDVGMMGGASVN------RAHRPTGGA 251 Query: 133 ADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLPGTRRVVGAWVWNRNKETV 192 G V L A+ NI + + ++++ DK + G + + Sbjct: 252 G--VGAHVVQVLYDNAVKR-NIDLRMNTRGIEVLKDDKGTVKG-------ILVKGMYKGY 301 Query: 193 ETCHAKAVVLATGGASKVYQY------------TTNPDISSGDGIAMAWRAGCRVANLEF 240 A AV+LATGG +K + +TN + GDG+ +A AG + ++++ Sbjct: 302 YWVKADAVILATGGFAKNNERVAKLDPSLKGFISTNQPGAVGDGLDVAENAGGALKDMQY 361 Query: 241 NQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERGELAPRDIVARAI--- 297 Q HPT ++TEA+RG GA L +G RF+ E+ RD + AI Sbjct: 362 IQAHPTLSVKG---GVMVTEAVRGNGAILVNREGKRFV------NEITTRDKASAAILAQ 412 Query: 298 ----------DHEMKRLGADCMFLDISHKP-ADFIRQHFPMI-------------YEKLL 333 D K L ++ + P AD + + M Y L+ Sbjct: 413 TGKSAYLIFDDSVRKSLSKIDKYIGLGVAPTADSLVKLGKMEGIDGKALTETVARYNSLV 472 Query: 334 GLGIDLTQE--------------PVPIVPAAHYTCGGVMVDDHGRT------DVEGLYAI 373 G D E + + P HYT GGVM+D + GLY Sbjct: 473 SSGKDTDFERPNLPRALNEGNYYAIEVTPGVHYTMGGVMIDTKAEVMNAKKQVIPGLYGA 532 Query: 374 GEVSYTGLHGANRMASNSLLECLVYGWSAAEDITRRMP 411 GEV+ G+HGANR+ N++ + + +G A E+ + Sbjct: 533 GEVT-GGVHGANRLGGNAISDIITFGRLAGEEAAKYSK 569 >1QO8-A nrPDB Length = 566 Score = 335 bits (859), Expect = 3e-92, Method: Composition-based stats. Identities = 126/476 (26%), Positives = 197/476 (41%), Gaps = 100/476 (21%) Query: 5 PEHSCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGSTFYAQGGIAAVFDE---- 59 P + VL++G+G+AG + +L VI++ K P + G++ + GG+ AV + Sbjct: 118 PSETTQVLVVGAGSAGFNASLAAKKAGANVILVDKAPFSGGNSMISAGGMNAVGTKQQTA 177 Query: 60 ---TDSIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESY 116 D ++ +ED + G D V +A + VQWL G D Sbjct: 178 HGVEDKVEWFIEDAMKGGRQQNDIKLVTILAEQSADGVQWLESLGANLDD---------- 227 Query: 117 HLTREGGHSHRRIL--HAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLP 174 L R GG R H ++G E+ TL KA I S V L+V+D Sbjct: 228 -LKRSGGARVDRTHRPHGGKSSGPEIIDTL-RKAAKEQGIDTRLNSRVVKLVVNDD---- 281 Query: 175 GTRRVVGAWVWNRNKETVETCHAKAVVLATGGASK-----VYQYTTNPDIS-------SG 222 VVGA V ++ AK+VVLATGG Y T D++ +G Sbjct: 282 --HSVVGAVVHGKHTG-YYMIGAKSVVLATGGYGMNKEMIAYYRPTMKDMTSSNNITATG 338 Query: 223 DGIAMAWRAGCRVANLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFD 282 DG+ MA G + ++++ Q HPT + L++E +RG GA + DG RF+ Sbjct: 339 DGVLMAKEIGASMTDIDWVQAHPTV---GKDSRILISETVRGVGAVMVNKDGNRFIS--- 392 Query: 283 ERGELAPRDIVARAIDHEMKRLGADCMFLDISHKPADFIR--QHFPMIY----------- 329 EL RD + AI + A +F + +K A +R H M+Y Sbjct: 393 ---ELTTRDKASDAI-LKQPGQFAWIIFDNQLYKKAKMVRGYDHLEMLYKGDTVEQLAKS 448 Query: 330 ---------------EKLLGLGID-----------LTQEP---VPIVPAAHYTCGGVMVD 360 + G D +TQ P V + P H+T GGV ++ Sbjct: 449 TGMKVADLAKTVSDYNGYVASGKDTAFGRADMPLNMTQSPYYAVKVAPGIHHTMGGVAIN 508 Query: 361 DHGRT------DVEGLYAIGEVSYTGLHGANRMASNSLLECLVYGWSAAEDITRRM 410 ++GL+A GEV+ G+HG NR+ N++ + +V+G A ++ + Sbjct: 509 TTASVLDLQSKPIDGLFAAGEVT-GGVHGYNRLGGNAIADTVVFGRIAGDNAAKHA 563 >5ZYN-B nrPDB Length = 471 Score = 327 bits (838), Expect = 8e-90, Method: Composition-based stats. Identities = 123/486 (25%), Positives = 202/486 (41%), Gaps = 111/486 (22%) Query: 11 VLIIGSGAAGLSLALRLADQHQ--VIVLSKGPVTEGSTFYAQGGIAAVFDET-------D 61 V++IGSG AGL+ + RL +++ V++L K G++ A GI +T D Sbjct: 7 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGGNSIKASSGINGAHTDTQQNLKVMD 66 Query: 62 SIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTRE 121 + + ++DTL + G ++ + ++S ++WL FD + L + Sbjct: 67 TPELFLKDTLHSAKGRGVPSLMDKLTKESKSAIRWLQT---EFDLKLD-------LLAQL 116 Query: 122 GGHSHRRILHAADAT--GREVETTLVSKALNHPNIRVLERSNAVDLIVSDK---IGLPGT 176 GGHS R ++ G E+ L SK L + + SN V ++++ + I L Sbjct: 117 GGHSVPRTHRSSGKLPPGFEIVQAL-SKKLKDISSK---DSNLVQIMLNSEVVDIELDNQ 172 Query: 177 RRVVGAWVW--NRNKETVETCHAKAVVLATGGASK------------VYQYTTNPDISSG 222 V G N N++ +++ H VV +GG ++ TTN ++G Sbjct: 173 GHVTGVVYMDENGNRKIMKSHH---VVFCSGGFGYSKEMLKEYSPNLIHLPTTNGKQTTG 229 Query: 223 DGIAMAWRAGCRVANLEFNQFHPTALYHPQAR----NFLLTEALRGEGAYLKRP-DGTRF 277 DG + + G + +++ Q HPT P R FL EALRG G L P G RF Sbjct: 230 DGQKILSKLGAELIDMDQVQVHPTGFIDPNDRENNWKFLAAEALRGLGGILLHPTTGRRF 289 Query: 278 M-----------------PDFDERGELAPRDIVARAIDHEMKRLGADCMFLDISHKPADF 320 P D R L D V + + + + +S D Sbjct: 290 TNELSTRDTVTMEIQSKCPKNDNRALLVMSDKVYENYTNNINFYMSKNLIKKVSIN--DL 347 Query: 321 IRQH--------------------------FPMIYEKLLGLGIDLTQEPV----PIVPAA 350 IRQ+ P+I D++ E + P Sbjct: 348 IRQYDLQTTASELVTELKSYSDVNTKDTFDRPLIIN---AFDKDISTESTVYVGEVTPVV 404 Query: 351 HYTCGGVMVDDHGRTDVE--------GLYAIGEVSYTGLHGANRMASNSLLECLVYGWSA 402 H+T GGV +++ + + G++A GEVS G+HGANR+ +SLLEC+V+G +A Sbjct: 405 HFTMGGVKINEKSQVIKKNSESVLSNGIFAAGEVS-GGVHGANRLGGSSLLECVVFGKTA 463 Query: 403 AEDITR 408 A++I + Sbjct: 464 ADNIAK 469 >1D4E-A nrPDB Length = 572 Score = 322 bits (825), Expect = 2e-88, Method: Composition-based stats. Identities = 126/474 (26%), Positives = 189/474 (39%), Gaps = 97/474 (20%) Query: 7 HSCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGSTFYAQGGIAAVFDE------ 59 + DV+IIGSG AGL+ A+ D +VI+L K P+ G+T A GG+ A + Sbjct: 125 ETTDVVIIGSGGAGLAAAVSARDAGAKVILLEKEPIPGGNTKLAAGGMNAAETKPQAKLG 184 Query: 60 -TDSIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHL 118 D ++DT+ G I D V+ +A+N+ + WL G T + G S + Sbjct: 185 IEDKKQIMIDDTMKGGRNINDPELVKVLANNSSDSIDWLTSMGADM-TDVGRMGGASVN- 242 Query: 119 TREGGHSHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLPGTRR 178 SHR A G V L A+ + S V ++ + + Sbjct: 243 -----RSHRPTGGAG--VGAHVAQVLWDNAVKR-GTDIRLNSRVVRILED------ASGK 288 Query: 179 VVGAWVWNRNKETVETCHAKAVVLATGGASKVYQY------------TTNPDISSGDGIA 226 V G V A AVV+A GG +K + TN ++GDG+ Sbjct: 289 VTGVLVKG-EYTGYYVIKADAVVIAAGGFAKNNERVSKYDPKLKGFKATNHPGATGDGLD 347 Query: 227 MAWRAGCRVANLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERGE 286 +A +AG +L++ Q HPT Y P ++TEA+RG GA + +G RFM E Sbjct: 348 VALQAGAATRDLQYIQAHPT--YSPAG-GVMITEAVRGNGAIVVNREGNRFM------NE 398 Query: 287 LAPRDIVARAIDHEMKRLGADCMFLDISHKPADFIRQ--HFPMI---------------- 328 + RD + AI + K A +F D K I H ++ Sbjct: 399 ITTRDKASAAI-LQQKGESAYLVFDDSIRKSLKAIEGYVHLNIVKEGKTIEELAKQIDVP 457 Query: 329 ----------YEKLLGLGIDLTQE--------------PVPIVPAAHYTCGGVMVDDHGR 364 Y + G D E + I PA H+T GG+++D Sbjct: 458 AAELAKTVTAYNGFVKSGKDAQFERPDLPRELVVAPFYALEIAPAVHHTMGGLVIDTKAE 517 Query: 365 T-------DVEGLYAIGEVSYTGLHGANRMASNSLLECLVYGWSAAEDITRRMP 411 + GLYA GEV+ G+HGANR+ N++ + + YG A + Sbjct: 518 VKSEKTAKPITGLYAAGEVT-GGVHGANRLGGNAISDIVTYGRIAGASAAKFAK 570 >3GYX-A nrPDB Length = 662 Score = 70.9 bits (172), Expect = 1e-12, Method: Composition-based stats. Identities = 76/410 (18%), Positives = 131/410 (31%), Gaps = 75/410 (18%) Query: 6 EHSCDVLIIGSGAAGLSLALRLAD-------QHQVIVLSKGPVTEGSTFYAQG--GIAAV 56 EHS D+L++G G A + +++++ K + AQG I Sbjct: 20 EHSVDLLMVGGGMGNCGAAFEAVRWADKYAPEAKILLVDKASLERSGAV-AQGLSAINTY 78 Query: 57 FDETDSIDS--HVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEE 114 + ++ D V L+ + + + + V + G+ + Sbjct: 79 LGDNNADDYVRMVRTDLMG---LVREDLIYDLGRHVDDSVHLFEEWGLPVWIKDEHGHNL 135 Query: 115 SYHLTREGGHSHR------RILHAADATGREVETTLVSKALNHP--NIRVLERSNAVDLI 166 + G S R R E +V++A + R++ER V L+ Sbjct: 136 DGAQAKAAGKSLRNGDKPVRSGRWQIMINGESYKVIVAEAAKNALGQDRIIERIFIVKLL 195 Query: 167 VSDKIGLPGTRRVVGAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIA 226 + R+ GA +N V A A+V+A GGA VY+ S G+G+ Sbjct: 196 LDK----NTPNRIAGAVGFNLRANEVHIFKANAMVVACGGAVNVYR-----PRSVGEGMG 246 Query: 227 MAW--------------RAGCRVANLEFNQFHPTAL---YHPQARNFLLTEA----LRGE 265 AW + G + +E N+F P Y P FLL +A +GE Sbjct: 247 RAWYPVWNAGSTYTMCAQVGAEMTMME-NRFVPARFKDGYGPVGAWFLLFKAKATNCKGE 305 Query: 266 GAYLKRPDGTR-FMPDFDERGELAPRDIVARAIDHEMKRLGADCMFLD------------ 312 + + +G + P + + EM R G +++D Sbjct: 306 DYCATNRAMLKPYEERGYAKGHVIPTCLRNHMMLREM-REGRGPIYMDTKTALQTSFATM 364 Query: 313 ----ISHKPADFIRQHFPMI---YEKLLGLGIDLTQEPVPIVPAAHYTCG 355 H A+ M + I+P Y G Sbjct: 365 SPAQQKHLEAEAWEDFLDMCVGQANLWAATNCAPEERGSEIMPTEPYLLG 414 >4C3X-A nrPDB Length = 530 Score = 50.5 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 68/341 (19%), Positives = 112/341 (32%), Gaps = 67/341 (19%) Query: 8 SCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGSTFYAQGGI----------AAV 56 CDVL++GSG L+ A A Q IVL K G++ Y+ I A + Sbjct: 27 ECDVLVVGSGGGALTGAYTAAAQGLTTIVLEKTDRFGGTSAYSGASIWLPGTQVQERAGL 86 Query: 57 FDETDSIDSHV------EDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQP 110 D T++ +++ ++ A + AV + + + + Sbjct: 87 PDSTENARTYLRALLGDAESERQDAYVETAPAVVALLEQNPNIEFEFRAFPDYYKAEGRM 146 Query: 111 NGEESYH--------LTREGGHSHR-----RIL--HAADAT--GREVETTLVSKALNHPN 153 + S + + G R HA GR + L++ + Sbjct: 147 DTGRSINPLDLDPADIGDLAGKVRPELDQDRTGQDHAPGPMIGGRALIGRLLAAVQSTGK 206 Query: 154 IRVLERSNAVDLIVSDKIGLPGTRRVVGAWVWNRNKETVETCHA-KAVVLATGG------ 206 + S LIV D RVVGA V + + + A + V++A GG Sbjct: 207 AELRTESVLTSLIVEDG-------RVVGAEVESGGET--QRIKANRGVLMAAGGIEGNAE 257 Query: 207 -------ASKVYQYTTNPDISSGDGIAMAWRAGCRVANLEFNQFHPTALYHPQARNFLLT 259 K ++GD I+ G A L+ F P + P + Sbjct: 258 MREQAGTPGKAIWSMGPFGANTGDAISAGIAVGGATALLDQAWFCP-GVEQPDGSAAFMV 316 Query: 260 EALRGEGAYLKRPDGTRFMPDFDERGELAPRDIVARAIDHE 300 +R G + G R++ E P D RA+D Sbjct: 317 -GVR--GGLVVDSAGERYL------NESLPYDQFGRAMDAH 348 >1FEC-A nrPDB Length = 490 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 65/388 (16%), Positives = 114/388 (29%), Gaps = 74/388 (19%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQHQ--VIVLSKGPVTEGSTFYAQGGIAAVFDETDSI 63 + D+++IG+G+ GL A H+ V V+ + A GG Sbjct: 1 SRAYDLVVIGAGSGGLEAGWNAASLHKKRVAVIDLQKHHGPPHYAALGGTCVNVGCVPKK 60 Query: 64 DS----HVEDTLIAGAGIC---DRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGE--- 113 + DT+ AG DR +V + L + Sbjct: 61 LMVTGANYMDTIRESAGFGWELDRESVR-------------PNWKALIAAKNKAVSGIND 107 Query: 114 --ESYHLTREGGHSHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKI 171 E EG H+ D T++ + PN VLE + ++++ Sbjct: 108 SYEGMFADTEGLTFHQGFGALQDN------HTVLVRESADPNSAVLETLDTEYILLATGS 161 Query: 172 GLPGTRRVVGAWVWNRNKETVETCHAKAVVLATGGASKVYQYTT-NPDISSGDGIAMAWR 230 N+ K + GG + N + G + +A+R Sbjct: 162 WPQHLGIEGDDLCITSNEAFYLDEAPKRALCVGGGYISIEFAGIFNAYKARGGQVDLAYR 221 Query: 231 AGCRVANLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERGELAPR 290 + + LTE LR G + + R Sbjct: 222 GDMILRGFD------------SELRKQLTEQLRANG---INVRTHENPAKVTKNAD-GTR 265 Query: 291 DIVARAIDHEMKRLGADCMFLDISHKPADFIRQHFPMIYEKLLGLGIDLTQEPVPIVPAA 350 +V + D + L I P Q L G+++ + Sbjct: 266 HVVFESGAEA----DYDVVMLAIGRVPRSQTLQ--------LEKAGVEVAKN-------- 305 Query: 351 HYTCGGVMVDDHGRTDVEGLYAIGEVSY 378 G + VD + +T+V+ +YAIG+V+ Sbjct: 306 ----GAIKVDAYSKTNVDNIYAIGDVTD 329 >3ATQ-A nrPDB Length = 453 Score = 43.2 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 40/211 (18%), Positives = 67/211 (31%), Gaps = 47/211 (22%) Query: 4 LPEHSCDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDETDSI 63 + E DVLIIG G AG S A +L+ + I+L DS Sbjct: 2 MKELKYDVLIIGGGFAGSSAAYQLSRRGLKILLV-----------------------DSK 38 Query: 64 DSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGE-ESYHLTREG 122 I D+ + V+ G+ + + + L Sbjct: 39 PW---------NRIGDKPCGDAVSKAH------FDKLGMPYPKGEELENKINGIKLYSPD 83 Query: 123 GHSHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLPGTRRVVGA 182 + + + V K + + + + A+ I D V GA Sbjct: 84 MQTVWTVNGEGFELNAPLYNQRVLKEAQDRGVEIWDLTTAMKPIFEDGY-------VKGA 136 Query: 183 WVWNRNKETVETCHAKAVVLATGGASKVYQY 213 ++NR T ++K VV AT G S+ ++ Sbjct: 137 VLFNRRTNEELTVYSKVVVEAT-GYSRSFRS 166 >2GMH-A nrPDB Length = 584 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 46/219 (21%), Positives = 69/219 (31%), Gaps = 44/219 (20%) Query: 7 HSCDVLIIGSGAAGLSLALRLADQH-------QVIVLSKGPVTEGSTFYAQGGIAAVFDE 59 DV+I+G+G AGLS A RL +V ++ K T ++ + Sbjct: 34 EEADVVIVGAGPAGLSAATRLKQLAAQHEKDLRVCLVEKAAHIGAHT------LSGACLD 87 Query: 60 TDSIDSHVEDTLIAGAGICDRHAVE---FVASNARSCVQWLIDQGVLFDTHIQPNGEESY 116 + + D GA + + + R V L G+ + H G Sbjct: 88 PRAFEELFPDWKEKGAPLNTPVTEDRFGILTEKYRIPVPILP--GLPMNNH----GNYVV 141 Query: 117 HLTREGGHSHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLPGT 176 L GH + A+A G EV +P + A L D Sbjct: 142 RL----GHLVSWMGEQAEALGVEV----------YPG-----YAAAEILFHEDGSVKGIA 182 Query: 177 RRVVGAWVWNRNKETVET---CHAKAVVLATGGASKVYQ 212 VG K T E HAK + A G + + Sbjct: 183 TNDVGIQKDGAPKTTFERGLELHAKVTIFAEGCHGHLAK 221 >4YKF-A nrPDB Length = 521 Score = 40.1 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 40/267 (14%), Positives = 86/267 (32%), Gaps = 30/267 (11%) Query: 128 RILHAADATGREVETTLV---------SKALNHPN-IRVLERSNAVDLIVSDKIGLPGTR 177 R + G ++ T+ ++ ++V VD+I S Sbjct: 237 RTGLMGERFGGQILDTVDIENYISVPKTEGQKLAGALKVHVDEYDVDVIDSQSASKLIPA 296 Query: 178 RVVGAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVAN 237 V G + A+++++ATG + N ++ D C + Sbjct: 297 AVEGGL-HQIETASGAVLKARSIIVATGAKWR------NMNVPGEDQYRTKGVTYCPHCD 349 Query: 238 LEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDF-------DERGELAPR 290 + A+ EA ++ F P+ D+ L Sbjct: 350 GPLFKGKRVAVIGGGNSGV---EAAIDLAGIVEHVTLLEFAPEMKADQVLQDKLRSLKNV 406 Query: 291 DIVARAIDHEMKRLGADCMFLDISHKPADFIRQHFPMIYEKLLGLGIDLTQEPVPIVPAA 350 DI+ A E+K G+ + L+ + + I + + +G+ + Sbjct: 407 DIILNAQTTEVKGDGSKVVGLEYRDRVSGDIHNI--ELAGIFVQIGLLPNTNWLEGA-VE 463 Query: 351 HYTCGGVMVDDHGRTDVEGLYAIGEVS 377 G +++D T+V+G++A G+ + Sbjct: 464 RNRMGEIIIDAKCETNVKGVFAAGDCT 490 >5EZ7-A nrPDB Length = 392 Score = 39.7 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 16/49 (32%), Positives = 24/49 (48%), Gaps = 1/49 (2%) Query: 8 SCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGSTFYAQGGIAA 55 S D+LI+G G AGL L RL +++ + G + +QG I Sbjct: 7 STDILIVGGGIAGLWLNARLRRAGYATVLVESASLGGGQSVKSQGIIHG 55 >5JCN-A nrPDB Length = 451 Score = 39.4 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 15/69 (21%), Positives = 31/69 (44%), Gaps = 3/69 (4%) Query: 355 GGVMVDDHGRTDVEGLYAIGEVSYTGLHGANRMASNSLLECLVYGWSAAEDITRRMPYAH 414 GG+ D T V G+YA+G+V+ + N + +E + + +AE + + Sbjct: 294 GGIKTDAFFETSVPGVYAVGDVATFPMKMYNEL---RRVEHVDHARKSAEQAVKAIKGKE 350 Query: 415 DISTLPPWD 423 ++ +D Sbjct: 351 SGESVVEYD 359 >1FL2-A nrPDB Length = 310 Score = 39.0 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 40/267 (14%), Positives = 86/267 (32%), Gaps = 30/267 (11%) Query: 128 RILHAADATGREVETTLV---------SKALNHPN-IRVLERSNAVDLIVSDKIGLPGTR 177 R + G ++ T+ ++ ++V VD+I S Sbjct: 26 RTGLMGERFGGQILDTVDIENYISVPKTEGQKLAGALKVHVDEYDVDVIDSQSASKLIPA 85 Query: 178 RVVGAWVWNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVAN 237 V G + A+++++ATG + N ++ D C + Sbjct: 86 AVEGGL-HQIETASGAVLKARSIIVATGAKWR------NMNVPGEDQYRTKGVTYCPHCD 138 Query: 238 LEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDF-------DERGELAPR 290 + A+ EA ++ F P+ D+ L Sbjct: 139 GPLFKGKRVAVIGGGNSGV---EAAIDLAGIVEHVTLLEFAPEMKADQVLQDKLRSLKNV 195 Query: 291 DIVARAIDHEMKRLGADCMFLDISHKPADFIRQHFPMIYEKLLGLGIDLTQEPVPIVPAA 350 DI+ A E+K G+ + L+ + + I + + +G+ + Sbjct: 196 DIILNAQTTEVKGDGSKVVGLEYRDRVSGDIHNI--ELAGIFVQIGLLPNTNWLEGA-VE 252 Query: 351 HYTCGGVMVDDHGRTDVEGLYAIGEVS 377 G +++D T+V+G++A G+ + Sbjct: 253 RNRMGEIIIDAKCETNVKGVFAAGDCT 279 >3IHG-A nrPDB Length = 535 Score = 38.2 bits (87), Expect = 0.010, Method: Composition-based stats. Identities = 15/46 (32%), Positives = 24/46 (52%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQG 51 +H DVL++G+G GLS A+ LA Q +++ + A G Sbjct: 3 DHEVDVLVVGAGLGGLSTAMFLARQGVRVLVVERRPGLSPYPRAAG 48 >5MOG-A nrPDB Length = 497 Score = 37.1 bits (84), Expect = 0.019, Method: Composition-based stats. Identities = 22/63 (34%), Positives = 29/63 (46%), Gaps = 10/63 (15%) Query: 5 PEHSCDVLIIGSGAAGLSLALRLADQ-HQVIVLSKGPVTEGSTFYAQGGIAAVFDETDSI 63 P V+I G+G AGLS A LAD H+ I+L V GG A + + D Sbjct: 14 PTKPLQVVIAGAGLAGLSTAKYLADAGHKPILLEARDVL--------GGKIAAWKDEDG- 64 Query: 64 DSH 66 D + Sbjct: 65 DWY 67 >2Q7V-A nrPDB Length = 325 Score = 37.1 bits (84), Expect = 0.020, Method: Composition-based stats. Identities = 16/44 (36%), Positives = 21/44 (47%), Gaps = 2/44 (4%) Query: 2 NTLPE-HSCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTE 43 T P H DV+IIG G AGL+ A+ ++L KG Sbjct: 1 MTAPTAHDYDVVIIGGGPAGLTAAIYTGRAQLSTLILEKGMPGG 44 >5EB4-A nrPDB Length = 532 Score = 36.7 bits (83), Expect = 0.024, Method: Composition-based stats. Identities = 17/52 (32%), Positives = 31/52 (59%), Gaps = 2/52 (3%) Query: 2 NTLPEHSCDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEG--STFYAQG 51 +T E S D ++IG G +G LA L+++++V++L +G + +T A G Sbjct: 20 DTSSEGSYDYIVIGGGTSGCPLAATLSEKYKVLLLERGTIATEYPNTLTADG 71 >5L46-A nrPDB Length = 841 Score = 36.3 bits (82), Expect = 0.034, Method: Composition-based stats. Identities = 30/118 (25%), Positives = 46/118 (38%), Gaps = 12/118 (10%) Query: 10 DVLIIGSGAAGLSLALRLADQH--QVIVLSKGPVTEGSTFYAQGGIAAVFDETDSIDSHV 67 + +IIG G G+SLA LA V++L K +T GST++A G + H Sbjct: 24 ETVIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIH- 82 Query: 68 EDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTREGGHS 125 D++ E + V + + T E Y +TR G H+ Sbjct: 83 YDSIK---------LYEKLEEETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHA 131 >3SM8-A nrPDB Length = 381 Score = 36.3 bits (82), Expect = 0.035, Method: Composition-based stats. Identities = 12/40 (30%), Positives = 19/40 (47%) Query: 8 SCDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTF 47 D L+IG+G AG S L+ +V+VL + + Sbjct: 9 EADYLVIGAGIAGASTGYWLSAHGRVVVLEREAQPGYHST 48 >4P9S-A nrPDB Length = 848 Score = 36.3 bits (82), Expect = 0.039, Method: Composition-based stats. Identities = 24/66 (36%), Positives = 33/66 (50%), Gaps = 9/66 (13%) Query: 10 DVLIIGSGAAGLSLALRLADQH--QVIVLSKGPVTEGSTFYAQG-------GIAAVFDET 60 + +IIG G G+SLA LA V++L K +T GST++A G GI Sbjct: 25 ETVIIGGGCVGVSLAYHLAKAGMRDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHY 84 Query: 61 DSIDSH 66 DSI + Sbjct: 85 DSIKLY 90 >1GPE-A nrPDB Length = 587 Score = 35.9 bits (81), Expect = 0.040, Method: Composition-based stats. Identities = 28/152 (18%), Positives = 53/152 (34%), Gaps = 22/152 (14%) Query: 7 HSCDVLIIGSGAAGLSLALRLAD--QHQVIVLSKGPVTEGSTFY-----AQGGIAAVFDE 59 + D +I G G GL++A +L + + +V+V+ KG A G I + Sbjct: 23 KTYDYIIAGGGLTGLTVAAKLTENPKIKVLVIEKGFYESNDGAIIEDPNAYGQIFGTTVD 82 Query: 60 TDSIDSHV----EDTLIAGAGICDRHAVEFVASNARSCVQ---WLIDQGVL-------FD 105 + + + + + AG G+ + + VQ W G+ F+ Sbjct: 83 QNYLTVPLINNRTNNIKAGKGLGGSTLINGDSWTRPDKVQIDSWEKVFGMEGWNWDNMFE 142 Query: 106 THIQPNGEESYHLTRE-GGHSHRRILHAADAT 136 + + + GHS H + T Sbjct: 143 YMKKAEAARTPTAAQLAAGHSFNATCHGTNGT 174 >5MJK-A nrPDB Length = 327 Score = 35.9 bits (81), Expect = 0.048, Method: Composition-based stats. Identities = 14/41 (34%), Positives = 23/41 (56%), Gaps = 1/41 (2%) Query: 4 LPEHSCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTE 43 + E DV+IIGSG AG++ A+ A + ++L +G Sbjct: 20 MTEKKYDVVIIGSGPAGMTAAMYTARSEMKTLLLERGVPGG 60 Score = 30.1 bits (66), Expect = 2.2, Method: Composition-based stats. Identities = 18/76 (23%), Positives = 33/76 (43%), Gaps = 1/76 (1%) Query: 301 MKRLGADCMFLDISHKPADFIRQHFPMIYEKLLGLGIDLTQEPVPIVPAAHYTCGGVMVD 360 M+ G D + +K + +G+D E V + G ++ D Sbjct: 223 MEIKGDDKKIQSVVYKNVKTGEVTEKAFGGIFIYVGLDPVAEFVSDL-GITDEAGWIITD 281 Query: 361 DHGRTDVEGLYAIGEV 376 DH RT++ G++A+G+V Sbjct: 282 DHMRTNIPGIFAVGDV 297 >3CP8-A nrPDB Length = 641 Score = 35.5 bits (80), Expect = 0.066, Method: Composition-based stats. Identities = 17/52 (32%), Positives = 24/52 (46%), Gaps = 3/52 (5%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQHQVIVL---SKGPVTEGSTFYAQGGIA 54 H DV+++G+G AG AL +A +L V S A GG+A Sbjct: 19 SHMYDVIVVGAGHAGCEAALAVARGGLHCLLITSDLSAVARMSCNPAIGGVA 70 >3GDN-A nrPDB Length = 521 Score = 35.1 bits (79), Expect = 0.074, Method: Composition-based stats. Identities = 19/58 (32%), Positives = 32/58 (55%), Gaps = 2/58 (3%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQHQVIVLSKG--PVTEGSTFYAQGGIAAVFDETD 61 E S D +I+G G +G LA L+++++V+VL +G P + A G + + E D Sbjct: 24 EGSYDYVIVGGGTSGCPLAATLSEKYKVLVLERGSLPTAYPNVLTADGFVYNLQQEDD 81 >4H7U-A nrPDB Length = 602 Score = 35.1 bits (79), Expect = 0.075, Method: Composition-based stats. Identities = 21/76 (27%), Positives = 35/76 (46%), Gaps = 4/76 (5%) Query: 9 CDVLIIGSGAAGLSLALRLADQH--QVIVLSKGPVTEGSTFYAQGGIAAVFDETDSIDSH 66 D ++ G G AGL +A RL++ +V+V+ GP + + G+A+ ID + Sbjct: 41 YDFIVAGGGTAGLVVASRLSENSNWKVLVIEAGPSNKDAFVTRVPGLASTLGAGSPIDWN 100 Query: 67 VEDTLIAGAGICDRHA 82 T I G+ R Sbjct: 101 Y--TTIPQDGLDGRSL 114 >2WOV-A nrPDB Length = 495 Score = 35.1 bits (79), Expect = 0.075, Method: Composition-based stats. Identities = 71/398 (17%), Positives = 122/398 (30%), Gaps = 94/398 (23%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQH--QVIVLSKGPVTEGSTFYAQGGIAAVFDETDSI 63 + D+++IG+G+ GL A + +V V+ + A GG Sbjct: 5 SKAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVG----- 59 Query: 64 DSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTREGG 123 C + + ++ G FD S Sbjct: 60 --------------CVPKKLMVTGAQYMDHLRESAGFGWEFD-------GSSVK------ 92 Query: 124 HSHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLPGTRRVVGAW 183 ++ + L AA ++ ++ + + +D + G ++ VV Sbjct: 93 -ANWKKLIAAKN------EAVLDINKSYEG--MFNDTEGLDFFL--GWGSLESKNVVVVR 141 Query: 184 VWNRNKETV-ETCHAKAVVLATGG-------ASKVYQYTTNP----------DISSGDGI 225 K V E A ++LATG + ++N ++ G G Sbjct: 142 ETADPKSAVKERLQADHILLATGSWPQMPAIPGIEHCISSNEAFYLPEPPRRVLTVGGGF 201 Query: 226 AMAWRAGCRVANLEFNQFHPTA-LYHPQARNFLL----TEALRGEGAYLKRPDGTRFMPD 280 AG FN + P RN L+ E +R E +G M + Sbjct: 202 ISVEFAGI------FNAYKPPGGKVTLCYRNNLILRGFDETIREEVTKQLTANGIEIMTN 255 Query: 281 FDERGELAPRDIVARAIDHEMKRLGADCMFLDISHKPADFIRQHFPMIYEKLLGLGIDLT 340 + D K L D + + I P Q L +G+ LT Sbjct: 256 ENPAKVSLNTDGSKHVTFESGKTLDVDVVMMAIGRIPRTNDLQ--------LGNVGVKLT 307 Query: 341 QEPVPIVPAAHYTCGGVMVDDHGRTDVEGLYAIGEVSY 378 + GGV VD+ RT+V +YAIG+++ Sbjct: 308 PK------------GGVQVDEFSRTNVPNIYAIGDITD 333 >2GAG-B nrPDB Length = 405 Score = 35.1 bits (79), Expect = 0.076, Method: Composition-based stats. Identities = 19/47 (40%), Positives = 25/47 (53%), Gaps = 3/47 (6%) Query: 2 NTLPEHSCDVLIIGSGAAGLSLALRLADQH---QVIVLSKGPVTEGS 45 N P+ S D +I+G G GL+ A LA H V VL KG + G+ Sbjct: 15 NPEPKKSYDAIIVGGGGHGLATAYFLAKNHGITNVAVLEKGWLAGGN 61 >6N7F-A nrPDB Length = 453 Score = 34.7 bits (78), Expect = 0.096, Method: Composition-based stats. Identities = 12/36 (33%), Positives = 21/36 (58%) Query: 9 CDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEG 44 D ++IG G+AG++ A R A ++L++G G Sbjct: 8 YDYIVIGGGSAGIASANRAAMHGAKVLLAEGKEIGG 43 >2BXR-A nrPDB Length = 527 Score = 34.7 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 16/45 (35%), Positives = 23/45 (51%), Gaps = 1/45 (2%) Query: 3 TLPEHSCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGST 46 ++ H DV++IG G +GLS A L + V+VL G T Sbjct: 8 SIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRT 52 >3RED-A nrPDB Length = 521 Score = 34.4 bits (77), Expect = 0.12, Method: Composition-based stats. Identities = 23/75 (30%), Positives = 37/75 (49%), Gaps = 2/75 (2%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQHQVIVLSKGP-VTEGSTFYAQGGIAAVFDETDSID 64 E S D +I+G G +G LA L+++++V+VL +G T G + D Sbjct: 24 EGSYDYVIVGGGTSGCPLAATLSEKYKVLVLERGTLPTAYPNLLTSDGFIYNLQQEDDGQ 83 Query: 65 SHVEDTLIAGAGICD 79 + VE + +G GI D Sbjct: 84 TPVERFV-SGDGIDD 97 >3G05-A nrPDB Length = 576 Score = 34.4 bits (77), Expect = 0.12, Method: Composition-based stats. Identities = 50/210 (23%), Positives = 69/210 (32%), Gaps = 59/210 (28%) Query: 9 CDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDETDSIDSHVE 68 DV+IIG G AG A+ A Q +L H Sbjct: 33 FDVIIIGGGHAGTEAAMAAARMGQQTLLLT---------------------------HNI 65 Query: 69 DTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTREGGHSHRR 128 DTL G C+ + V+ + G L I G + L G + R Sbjct: 66 DTL--GQMSCNPAIGGIGKGH---LVKEVDALGGLMAKAIDQAGIQFRILNASKGPAVRA 120 Query: 129 ILHAADATGREVETTLVSKALN-----HPNIRVLERSNAVDLIVSDKIGLPGTRRVVGAW 183 AD L +A+ PN+ + +++ DLIV + RVVGA Sbjct: 121 TRAQADRV-------LYRQAVRTALENQPNLMIFQQA-VEDLIVEND-------RVVGAV 165 Query: 184 VWNRNKETVETCHAKAVVLATGGA--SKVY 211 K AKAVVL G K++ Sbjct: 166 TQMGLK-----FRAKAVVLTVGTFLDGKIH 190 >3CP2-A nrPDB Length = 649 Score = 34.4 bits (77), Expect = 0.12, Method: Composition-based stats. Identities = 50/210 (23%), Positives = 69/210 (32%), Gaps = 59/210 (28%) Query: 9 CDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDETDSIDSHVE 68 DV+IIG G AG A+ A Q +L H Sbjct: 27 FDVIIIGGGHAGTEAAMAAARMGQQTLLLT---------------------------HNI 59 Query: 69 DTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTREGGHSHRR 128 DTL G C+ + V+ + G L I G + L G + R Sbjct: 60 DTL--GQMSCNPAIGGIGKGH---LVKEVDALGGLMAKAIDQAGIQFRILNASKGPAVRA 114 Query: 129 ILHAADATGREVETTLVSKALN-----HPNIRVLERSNAVDLIVSDKIGLPGTRRVVGAW 183 AD L +A+ PN+ + +++ DLIV + RVVGA Sbjct: 115 TRAQADRV-------LYRQAVRTALENQPNLMIFQQA-VEDLIVEND-------RVVGAV 159 Query: 184 VWNRNKETVETCHAKAVVLATGGA--SKVY 211 K AKAVVL G K++ Sbjct: 160 TQMGLK-----FRAKAVVLTVGTFLDGKIH 184 >2YAU-A nrPDB Length = 511 Score = 34.4 bits (77), Expect = 0.13, Method: Composition-based stats. Identities = 72/450 (16%), Positives = 133/450 (29%), Gaps = 110/450 (24%) Query: 6 EHSCDVLIIGSGAAGLSLA--LRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDETDSI 63 + D++++G+G+ GL + + +V V+ F A GG Sbjct: 22 SRAYDLVVLGAGSGGLEAGWNAAVTHKKKVAVVDVQATHGPPLFAALGGTCVNVG----- 76 Query: 64 DSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTREGG 123 C L+ G + I+ +G + + RE Sbjct: 77 --------------CVPK--------------KLMVTGAQYMDLIRESGGFGWEMDRESL 108 Query: 124 HSHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLPGTRRVVGAW 183 + + L AA V ++N + + + L VV Sbjct: 109 CPNWKTLIAAKNK--------VVNSINESYKSMFADTEGLSF-HMGFGALQDAHTVVVRK 159 Query: 184 VWNRNKETVETCHAKAVVLATGG-------ASKVYQYTTNPD----------ISSGDGIA 226 + + + +ET + +++ATG + T+N + G G Sbjct: 160 SEDPHSDVLETLDTEYILIATGSWPTRLGVPGDEFCITSNEAFYLEDAPKRMLCVGGGYI 219 Query: 227 MAWRAGCRVANLEFNQFHPTALY-HPQARNFLLTEA----LRGEGAYLKRPDGTRFMPDF 281 AG FN + P Y R L+ +R +G R + Sbjct: 220 AVEFAGI------FNGYKPCGGYVDLCYRGDLILRGFDTEVRKSLTKQLGANGIRVRTNL 273 Query: 282 DERGELAPRDIVARAIDHEMKRLGADCMFLDISHKPADFIRQHFPMIYEKLLGLGIDLTQ 341 + D ++ D + L I P Q + + + G + Sbjct: 274 NPTKITKNEDGSNHVHFNDGTEEDYDQVMLAIGRVPRSQALQ----LDKAGVRTGKN--- 326 Query: 342 EPVPIVPAAHYTCGGVMVDDHGRTDVEGLYAIGEVSYTGLHGANRM--------ASNSLL 393 G V VD + +T V+ +YAIG+V+ NR+ + + Sbjct: 327 -------------GAVQVDAYSKTSVDNIYAIGDVT-------NRVMLTPVAINEGAAFV 366 Query: 394 ECLVYGWSAAEDITRRMPYAHDISTLPPWD 423 E + G T A + ++PP Sbjct: 367 ETVFGGK---PRATDHTKVACAVFSIPPIG 393 >1XHC-A nrPDB Length = 367 Score = 34.4 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 13/32 (40%), Positives = 21/32 (65%) Query: 11 VLIIGSGAAGLSLALRLADQHQVIVLSKGPVT 42 V+I+G+G G LA +L+ ++V V+ K PV Sbjct: 11 VVIVGNGPGGFELAKQLSQTYEVTVIDKEPVP 42 >1NAA-A nrPDB Length = 541 Score = 34.0 bits (76), Expect = 0.16, Method: Composition-based stats. Identities = 12/44 (27%), Positives = 23/44 (52%), Gaps = 3/44 (6%) Query: 9 CDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGG 52 D +I+G+G G+ A RL++ + ++L + G + GG Sbjct: 3 YDYIIVGAGPGGIIAADRLSEAGKKVLLLE---RGGPSTKQTGG 43 >4GCM-A nrPDB Length = 312 Score = 34.0 bits (76), Expect = 0.17, Method: Composition-based stats. Identities = 10/41 (24%), Positives = 23/41 (56%), Gaps = 1/41 (2%) Query: 4 LPEHSCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTE 43 + E D+ IIG+G AG++ A+ + + + +++ +G Sbjct: 2 MTEIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGG 42 >5UWY-A nrPDB Length = 308 Score = 33.6 bits (75), Expect = 0.25, Method: Composition-based stats. Identities = 14/36 (38%), Positives = 20/36 (55%), Gaps = 1/36 (2%) Query: 9 CDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTE 43 D LIIGSG AG++ AL A + V ++ +G Sbjct: 5 YDTLIIGSGPAGMTAALYAARSNLSVAIIEQGAPGG 40 >4NEW-A nrPDB Length = 492 Score = 33.2 bits (74), Expect = 0.27, Method: Composition-based stats. Identities = 78/428 (18%), Positives = 132/428 (30%), Gaps = 73/428 (17%) Query: 9 CDVLIIGSGAAGLSLALRLADQHQ--VIVLSKGPVTEGSTFYAQGGIAAVFDETDSIDSH 66 D+++IG+G+ GL A A ++ V V+ V F A GG Sbjct: 6 FDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGTCVNVG-------- 57 Query: 67 VEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFD-THIQPNGEESYHLTREGGHS 125 C + + ++ G FD T ++ + + E + Sbjct: 58 -----------CVPKKLMVTGAQYMEHLRESAGFGWEFDRTTLRAEWKNLIAVKDEAVLN 106 Query: 126 HRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLPGTRRVVGAWVW 185 + +E L +L N+ + S V +++ G+W Sbjct: 107 INKSYDEMFRDTEGLEFFLGWGSLESKNVVNVRESADPASAVKERLETEHILLASGSWPH 166 Query: 186 NRNKETVETCHAKAVVLATGGASKVYQY-TTNPDISSGDGIAMAWRAGCRVANLEFNQFH 244 N +E C + Y ++ G G AG FN + Sbjct: 167 MPNIPGIEHCISSNEAF--------YLPEPPRRVLTVGGGFISVEFAGI------FNAYK 212 Query: 245 PT-ALYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERGELAPRDIVARAIDHEMKR 303 P R ++ LRG D R EL + + A I K Sbjct: 213 PKDGQVTLCYRGEMI---LRG--------------FDHTLREEL-TKQLTANGIQILTKE 254 Query: 304 LGADCMFLDISHKPADFIRQHFPMIYEKLLGLGIDLTQEPVPIV-PAAHYTCGGVMVDDH 362 A K F ++ +G + + + GGV VD++ Sbjct: 255 NPAKVELNADGSKSVTFESGKKMDFDLVMMAIGRSPRTKDLQLQNAGVMIKNGGVQVDEY 314 Query: 363 GRTDVEGLYAIGEVSYTGLHGANR-----MASNSLLECL--VYGWSAAEDITRRMPYAHD 415 RT+V +YAIG+V+ NR +A N + V+G + T A Sbjct: 315 SRTNVSNIYAIGDVT-------NRVMLTPVAINEAAALVDTVFGTTP--RKTDHTRVASA 365 Query: 416 ISTLPPWD 423 + ++PP Sbjct: 366 VFSIPPIG 373 >1ZDL-A nrPDB Length = 517 Score = 33.2 bits (74), Expect = 0.30, Method: Composition-based stats. Identities = 15/49 (30%), Positives = 25/49 (51%), Gaps = 3/49 (6%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQHQVIVLSK--GPVTEGSTFYAQGG 52 + S D+L+IG G+ GL+ A A + + ++ P G T + GG Sbjct: 30 QQSFDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRG-TKWGLGG 77 >3NK2-X nrPDB Length = 431 Score = 33.2 bits (74), Expect = 0.32, Method: Composition-based stats. Identities = 8/28 (28%), Positives = 16/28 (57%) Query: 9 CDVLIIGSGAAGLSLALRLADQHQVIVL 36 D +++G G +GL A L + + ++L Sbjct: 2 YDAIVVGGGFSGLKAARDLTNAGKKVLL 29 >2JB2-A nrPDB Length = 489 Score = 33.2 bits (74), Expect = 0.32, Method: Composition-based stats. Identities = 16/46 (34%), Positives = 22/46 (47%), Gaps = 1/46 (2%) Query: 8 SCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGSTFYAQGG 52 S V+++G G AGL A L +V VL G + A+GG Sbjct: 11 SHSVVVLGGGPAGLCSAFELQKAGYKVTVLEARTRPGGRVWTARGG 56 >4NTC-A nrPDB Length = 335 Score = 32.8 bits (73), Expect = 0.39, Method: Composition-based stats. Identities = 16/27 (59%), Positives = 18/27 (66%) Query: 10 DVLIIGSGAAGLSLALRLADQHQVIVL 36 DVLIIG+G AGLS A LA Q V+ Sbjct: 16 DVLIIGAGPAGLSTATGLARQLHTAVV 42 >1O5W-A nrPDB Length = 534 Score = 32.8 bits (73), Expect = 0.41, Method: Composition-based stats. Identities = 13/40 (32%), Positives = 21/40 (52%), Gaps = 1/40 (2%) Query: 4 LPEHSCDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTE 43 L H DV++IG G +GL A +L ++++ VL Sbjct: 17 LAGHMFDVVVIGGGISGL-AAAKLLSEYKINVLVLEARDR 55 >3LAD-A nrPDB Length = 476 Score = 32.4 bits (72), Expect = 0.44, Method: Composition-based stats. Identities = 15/48 (31%), Positives = 23/48 (47%), Gaps = 3/48 (6%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGSTFYAQGG 52 DV++IG+G G A++ A + ++ K EG T A GG Sbjct: 1 SQKFDVIVIGAGPGGYVAAIKSAQLGLKTALIEKYKGKEGKT--ALGG 46 Score = 30.5 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 16/55 (29%), Positives = 23/55 (41%), Gaps = 8/55 (14%) Query: 355 GGVMVDDHGRTDVEGLYAIGEVSYTGL--HGANRMASNSLLECLVYGWSAAEDIT 407 G + VDD+ T V G+YAIG+V + H A+ +V A Sbjct: 298 GFIYVDDYCATSVPGVYAIGDVVRGAMLAHKASEEG------VVVAERIAGHKAQ 346 >4OVI-A nrPDB Length = 542 Score = 32.4 bits (72), Expect = 0.45, Method: Composition-based stats. Identities = 17/92 (18%), Positives = 32/92 (34%), Gaps = 21/92 (22%) Query: 5 PEHSCDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDETDSID 64 P DVL++G+G +GL RL + + + G + V+ Sbjct: 13 PPEEVDVLVVGAGFSGLYALYRLRELGRSV----------HVIETAGDVGGVW------- 55 Query: 65 SHVEDTLIAGAGICDRHAVEFVASNARSCVQW 96 + CD ++E+ S + +Q Sbjct: 56 --YWNRYPGAR--CDIESIEYCYSFSEEVLQE 83 >5KOX-A nrPDB Length = 476 Score = 32.4 bits (72), Expect = 0.46, Method: Composition-based stats. Identities = 15/42 (35%), Positives = 19/42 (45%), Gaps = 1/42 (2%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGST 46 H DV+I G G GL LA L + +VL K P + Sbjct: 2 SHMIDVIIAGGGPTGLMLAGELRLHGVRTVVLEKEPTPNQHS 43 >4ZCC-A nrPDB Length = 336 Score = 32.4 bits (72), Expect = 0.46, Method: Composition-based stats. Identities = 17/44 (38%), Positives = 22/44 (50%), Gaps = 6/44 (13%) Query: 2 NTLPEHSCDVLIIGSGAAGLSLALRLADQ-HQVIVLSKGPVTEG 44 T+P + IIG+G AGLS A L HQV + K + G Sbjct: 1 MTVP-----IAIIGTGIAGLSAAQALTSAGHQVHLFDKSRGSGG 39 >5X1Y-B nrPDB Length = 554 Score = 32.4 bits (72), Expect = 0.48, Method: Composition-based stats. Identities = 15/39 (38%), Positives = 24/39 (61%), Gaps = 1/39 (2%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTE 43 E + D+LIIGSGAA S A++ + +V ++ +G V Sbjct: 82 EDNYDLLIIGSGAAAFSSAIKAIEYGAKVGMIERGTVGG 120 >4AP1-A nrPDB Length = 549 Score = 32.4 bits (72), Expect = 0.49, Method: Composition-based stats. Identities = 19/94 (20%), Positives = 32/94 (34%), Gaps = 21/94 (22%) Query: 3 TLPEHSCDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDETDS 62 T S DV+++G+G AGL R Q + F A G+ V+ Sbjct: 16 TTGTTSYDVVVVGAGIAGLYAIHRFRSQGLTV----------RAFEAASGVGGVW----- 60 Query: 63 IDSHVEDTLIAGAGICDRHAVEFVASNARSCVQW 96 + CD ++++ S + Q Sbjct: 61 ----YWNRYPGAR--CDVESIDYSYSFSPELEQE 88 >1F8S-A nrPDB Length = 498 Score = 32.4 bits (72), Expect = 0.53, Method: Composition-based stats. Identities = 19/41 (46%), Positives = 23/41 (56%), Gaps = 4/41 (9%) Query: 5 PEHSCDVLIIGSGAAGLSLALRLADQ-HQVIVLSKGPVTEG 44 P+H V+I+G+G AGLS A LA HQV VL G Sbjct: 33 PKH---VVIVGAGMAGLSAAYVLAGAGHQVTVLEASERPGG 70 >1RP0-A nrPDB Length = 284 Score = 32.4 bits (72), Expect = 0.56, Method: Composition-based stats. Identities = 12/39 (30%), Positives = 22/39 (56%), Gaps = 2/39 (5%) Query: 8 SCDVLIIGSGAAGLSLALRLAD--QHQVIVLSKGPVTEG 44 DV+++G+G+AGLS A ++ QV ++ + G Sbjct: 39 ETDVVVVGAGSAGLSAAYEISKNPNVQVAIIEQSVSPGG 77 >4DX0-A nrPDB Length = 243 Score = 32.0 bits (71), Expect = 0.59, Method: Composition-based stats. Identities = 15/66 (22%), Positives = 25/66 (37%), Gaps = 11/66 (16%) Query: 459 RLERALRRITMLQQEIDEYYAHFRVSNNLLELRNLVQVAELIVRCA-----------MMR 507 +L R + + +++ V +E RNL+ VA V A + Sbjct: 19 KLAEQAERYEEMVEFMEKVAKTVDVEELTVEERNLLSVAYKNVIGARRASWRIISSIEQK 78 Query: 508 KESRGL 513 +ESRG Sbjct: 79 EESRGN 84 >3UKH-A nrPDB Length = 519 Score = 32.0 bits (71), Expect = 0.65, Method: Composition-based stats. Identities = 14/27 (51%), Positives = 17/27 (62%) Query: 3 TLPEHSCDVLIIGSGAAGLSLALRLAD 29 T P+ S DVL+IG+G GL A RL Sbjct: 1 THPDISVDVLVIGAGPTGLGAAKRLNQ 27 >5NWK-A nrPDB Length = 262 Score = 32.0 bits (71), Expect = 0.68, Method: Composition-based stats. Identities = 14/66 (21%), Positives = 24/66 (36%), Gaps = 11/66 (16%) Query: 459 RLERALRRITMLQQEIDEYYAHFRVSNNLLELRNLVQVAELIVRCA-----------MMR 507 +L R + + +++ +E RNL+ VA V A + Sbjct: 18 KLAEQAERYEEMVEFMEKVSNSLGSEELTVEERNLLSVAYKNVIGARRASWRIISSIEQK 77 Query: 508 KESRGL 513 +ESRG Sbjct: 78 EESRGN 83 >5BR7-A nrPDB Length = 393 Score = 32.0 bits (71), Expect = 0.70, Method: Composition-based stats. Identities = 13/44 (29%), Positives = 25/44 (56%), Gaps = 2/44 (4%) Query: 9 CDVLIIGSGAAGLSLALRLADQ--HQVIVLSKGPVTEGSTFYAQ 50 D++++GSG GL++A R A Q +V+++ K G+ + Sbjct: 4 FDLIVVGSGLFGLTVAERAASQLGKKVLIVEKRSHLGGNAYSEA 47 >4C5O-A nrPDB Length = 357 Score = 32.0 bits (71), Expect = 0.70, Method: Composition-based stats. Identities = 12/38 (31%), Positives = 17/38 (44%), Gaps = 1/38 (2%) Query: 8 SCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEG 44 S DV++IG G +GLS L ++L G Sbjct: 3 SVDVVVIGGGQSGLSAGYFLRRSGLSYVILDAEASPGG 40 >3KKJ-A nrPDB Length = 336 Score = 32.0 bits (71), Expect = 0.73, Method: Composition-based stats. Identities = 17/44 (38%), Positives = 22/44 (50%), Gaps = 6/44 (13%) Query: 2 NTLPEHSCDVLIIGSGAAGLSLALRLADQ-HQVIVLSKGPVTEG 44 T+P + IIG+G AGLS A L HQV + K + G Sbjct: 1 MTVP-----IAIIGTGIAGLSAAQALTAAGHQVHLFDKSRGSGG 39 >3R9U-A nrPDB Length = 315 Score = 32.0 bits (71), Expect = 0.73, Method: Composition-based stats. Identities = 15/43 (34%), Positives = 19/43 (44%), Gaps = 2/43 (4%) Query: 10 DVLIIGSGAAGLSLALRLADQH--QVIVLSKGPVTEGSTFYAQ 50 DV IIG G AGLS L V++ KG T ++ Sbjct: 6 DVAIIGGGPAGLSAGLYATRGGLKNVVMFEKGMPGGQITSSSE 48 >1YQZ-A nrPDB Length = 438 Score = 31.7 bits (70), Expect = 0.77, Method: Composition-based stats. Identities = 18/96 (18%), Positives = 35/96 (36%), Gaps = 22/96 (22%) Query: 355 GGVMVDDHGRTDVEGLYAIGEVS---------------YTGLHGANRMASNSLL--ECLV 397 G + V+D T+V +YAIG+++ G H A + + + + + Sbjct: 257 GFIPVNDKFETNVPNIYAIGDIATSHYRHVDLPASVPLAWGAHRAASIVAEQIAGNDTIE 316 Query: 398 YGWSAAEDITRRMPY-----AHDISTLPPWDESRVE 428 + +I + Y + L +D VE Sbjct: 317 FKGFLGNNIVKFFDYTFASVGVKPNELKQFDYKMVE 352 >5Y77-A nrPDB Length = 473 Score = 31.7 bits (70), Expect = 0.78, Method: Composition-based stats. Identities = 18/60 (30%), Positives = 25/60 (41%), Gaps = 1/60 (1%) Query: 1 MNTLPEHSCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGSTFYAQGGIAAVFDE 59 M T +++ V IIG+G AG +A LA QV + + P T I E Sbjct: 1 MGTATDNARQVTIIGAGLAGTLVARLLARNGWQVNLFERRPDPRIETGARGRSINLALAE 60 >2EQ6-A nrPDB Length = 464 Score = 31.7 bits (70), Expect = 0.80, Method: Composition-based stats. Identities = 10/41 (24%), Positives = 19/41 (46%) Query: 4 LPEHSCDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEG 44 P + D+++IG+G G A+R A ++ + G Sbjct: 2 TPMKTYDLIVIGTGPGGYHAAIRAAQLGLKVLAVEAGEVGG 42 Score = 28.6 bits (62), Expect = 6.8, Method: Composition-based stats. Identities = 18/70 (25%), Positives = 27/70 (38%), Gaps = 8/70 (11%) Query: 355 GGVMVDDHGRTDVEGLYAIGEVSYTGL--HGANRMASNSLLECLVYGWSAAEDITRRMPY 412 G + V+ T V G+YAIG+ + L H A R + +A +D Sbjct: 289 GFIRVNARMETSVPGVYAIGDAARPPLLAHKAMREG------LIAAENAAGKDSAFDYQV 342 Query: 413 AHDISTLPPW 422 + T P W Sbjct: 343 PSVVYTSPEW 352 >4UIR-A nrPDB Length = 646 Score = 31.7 bits (70), Expect = 0.81, Method: Composition-based stats. Identities = 21/83 (25%), Positives = 29/83 (34%), Gaps = 18/83 (21%) Query: 4 LPEHSCD---VLIIGSGAAGLSLALRLADQHQV-----IVLSKGPVTEGSTFYA------ 49 +P S D + IIGSG AG+S A V L + + GS A Sbjct: 55 IPVQSYDNSKIYIIGSGIAGMSAAYYFIRDGHVPAKNITFLEQLHIDGGSLDGAGNPTDG 114 Query: 50 ---QGGIAAVFDETDSIDSHVED 69 +GG + D +D Sbjct: 115 YIIRGGREMDMTYENLWD-MFQD 136 >4RPJ-A nrPDB Length = 399 Score = 31.7 bits (70), Expect = 0.85, Method: Composition-based stats. Identities = 15/44 (34%), Positives = 26/44 (59%), Gaps = 2/44 (4%) Query: 9 CDVLIIGSGAAGLSLALRLADQ--HQVIVLSKGPVTEGSTFYAQ 50 D+ ++GSG GL++A R+A Q +V+VL + P G+ + Sbjct: 8 FDLFVVGSGFFGLTIAERVATQLDKRVLVLERRPHIGGNAYSEA 51 >3OC4-A nrPDB Length = 452 Score = 31.7 bits (70), Expect = 0.86, Method: Composition-based stats. Identities = 16/62 (25%), Positives = 32/62 (51%), Gaps = 8/62 (12%) Query: 8 SCDVLIIGSGAAGLSLALRLADQH---QVIVLSKGPVTEGSTFYAQGGIAAVFDETDSID 64 S ++IIG+ AG+S A+ ++ ++ ++ K Y GG++A F+ T + + Sbjct: 2 SLKIVIIGASFAGISAAIASRKKYPQAEISLIDKQATVG----YLSGGLSAYFNHTIN-E 56 Query: 65 SH 66 H Sbjct: 57 LH 58 >3BI4-A nrPDB Length = 516 Score = 31.7 bits (70), Expect = 0.90, Method: Composition-based stats. Identities = 13/31 (41%), Positives = 16/31 (51%) Query: 1 MNTLPEHSCDVLIIGSGAAGLSLALRLADQH 31 MNT+ V+IIG+G AGL A L Sbjct: 1 MNTVSPAKKKVIIIGAGIAGLKAASTLHQNG 31 >5U8W-A nrPDB Length = 481 Score = 31.7 bits (70), Expect = 0.91, Method: Composition-based stats. Identities = 13/48 (27%), Positives = 19/48 (39%), Gaps = 3/48 (6%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGSTFYAQGG 52 DV++IG+G G A+R A + + K A GG Sbjct: 5 SQKFDVVVIGAGPGGYVAAIRAAQLGLKTACIEK--YIGKEGKVALGG 50 Score = 30.1 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 16/55 (29%), Positives = 24/55 (43%), Gaps = 8/55 (14%) Query: 355 GGVMVDDHGRTDVEGLYAIGEVSYTGL--HGANRMASNSLLECLVYGWSAAEDIT 407 G + VDDH +T V G++AIG+V + H A+ +V A Sbjct: 302 GFIYVDDHCKTSVPGVFAIGDVVRGAMLAHKASEEG------VMVAERIAGHKAQ 350 >4N9X-A nrPDB Length = 411 Score = 31.7 bits (70), Expect = 0.91, Method: Composition-based stats. Identities = 14/33 (42%), Positives = 18/33 (54%), Gaps = 1/33 (3%) Query: 7 HSCDVLIIGSGAAGLSLALRLADQH-QVIVLSK 38 S DV+I G G GL+LA L ++ VL K Sbjct: 2 QSFDVVIAGGGMVGLALACGLQGSGLRIAVLEK 34 >3RHA-A nrPDB Length = 482 Score = 31.7 bits (70), Expect = 0.97, Method: Composition-based stats. Identities = 28/127 (22%), Positives = 51/127 (40%), Gaps = 32/127 (25%) Query: 10 DVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGSTFYAQGGIAAVFDETDSIDSHVE 68 DV+I+G+G +GL+ A L V VL G T+ TD+ID + Sbjct: 9 DVVIVGAGPSGLTAARELKKAGLSVAVLEARDRVGGRTW------------TDTIDGAML 56 Query: 69 DTLIAGAGIC-DRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTREGGHSHR 127 + I G + D+ + ++ L + G+ + + ES ++ +G + Sbjct: 57 E--IGGQWVSPDQTVL----------MELLDELGLKM--YSRYRDGESVYIGADG----K 98 Query: 128 RILHAAD 134 R + D Sbjct: 99 RTQYTGD 105 >5EQD-A nrPDB Length = 400 Score = 31.3 bits (69), Expect = 0.99, Method: Composition-based stats. Identities = 14/40 (35%), Positives = 24/40 (60%), Gaps = 2/40 (5%) Query: 9 CDVLIIGSGAAGLSLALRLADQ--HQVIVLSKGPVTEGST 46 D+ ++GSG GL++A R A Q +V+V+ + P G+ Sbjct: 5 FDLFVVGSGFFGLTIAERAATQLGKRVLVIERRPHIGGNA 44 >2YQU-A nrPDB Length = 455 Score = 31.3 bits (69), Expect = 1.0, Method: Composition-based stats. Identities = 13/37 (35%), Positives = 19/37 (51%), Gaps = 1/37 (2%) Query: 9 CDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEG 44 D+L+IG+G G A+R A +V V+ K G Sbjct: 2 YDLLVIGAGPGGYVAAIRAAQLGMKVGVVEKEKALGG 38 >5W1J-A nrPDB Length = 584 Score = 31.3 bits (69), Expect = 1.0, Method: Composition-based stats. Identities = 16/28 (57%), Positives = 20/28 (71%) Query: 353 TCGGVMVDDHGRTDVEGLYAIGEVSYTG 380 T G V+VDD RT+V +YAIG+VS G Sbjct: 404 TNGRVVVDDEERTNVPNIYAIGDVSNAG 431 >2R9Z-A nrPDB Length = 463 Score = 31.3 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 59/373 (15%), Positives = 101/373 (27%), Gaps = 77/373 (20%) Query: 9 CDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDETDSIDSHVE 68 D++ IG G+ GL++A + A + + L + A GG Sbjct: 5 FDLIAIGGGSGGLAVAEKAAAFGKRVALIE--------SKALGGTCVNVG---------- 46 Query: 69 DTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTREGGHSHRR 128 C V + AS+ V+ GV GG Sbjct: 47 ---------CVPKKVMWYASHLAEAVRDAPGFGV----------------QASGGTLDWP 81 Query: 129 ILHAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLPGTRRVVGAWVWNRN 188 L A + + I ++ G R V A Sbjct: 82 RLVAGRDRYIGAINSFWDGYVERLGITRVD----------------GHARFVDAHTIEVE 125 Query: 189 KETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCRVANLEFNQFHPTAL 248 + A +V+ATGG V + + DG + Q A+ Sbjct: 126 GQ---RLSADHIVIATGGRPIVPRLPGAELGITSDGFFALQQ-----------QPKRVAI 171 Query: 249 YHPQARNFLLTEALRGEGA-YLKRPDGTRFMPDFDERGELA-PRDIVARAIDHEMKRLGA 306 L LR G+ R + FD ++ A+ I+ ++ A Sbjct: 172 IGAGYIGIELAGLLRSFGSEVTVVALEDRLLFQFDPLLSATLAENMHAQGIETHLEFAVA 231 Query: 307 DCMFLDISHKPADFIRQHFPMIYEKLLGLGIDLTQE--PVPIVPAAHYTCGGVMVDDHGR 364 + +G + + G V D + Sbjct: 232 ALERDAQGTTLVAQDGTRLEGFDSVIWAVGRAPNTRDLGLEAAGIEVQSNGMVPTDAYQN 291 Query: 365 TDVEGLYAIGEVS 377 T+V G+YA+G+++ Sbjct: 292 TNVPGVYALGDIT 304 >4IA5-A nrPDB Length = 591 Score = 31.3 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 17/40 (42%), Positives = 21/40 (52%), Gaps = 5/40 (12%) Query: 11 VLIIGSGAAGLSLALRLADQHQ-----VIVLSKGPVTEGS 45 IIGSG AGLS A+ L Q + +L + PV GS Sbjct: 25 AYIIGSGLAGLSTAVFLVRDAQMKGENIHILEELPVAGGS 64 >3O0H-A nrPDB Length = 484 Score = 30.9 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 8/46 (17%), Positives = 20/46 (43%) Query: 3 TLPEHSCDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFY 48 ++ D+ +IGSG+ G+ A + + +++ G+ Sbjct: 21 SMGSFDFDLFVIGSGSGGVRAARLAGALGKRVAIAEEYRIGGTCVI 66 >2CVJ-A nrPDB Length = 180 Score = 30.9 bits (68), Expect = 1.4, Method: Composition-based stats. Identities = 11/27 (40%), Positives = 18/27 (66%) Query: 10 DVLIIGSGAAGLSLALRLADQHQVIVL 36 DV+++G G +GLS AL LA +++ Sbjct: 3 DVIVVGGGPSGLSAALFLARAGLKVLV 29 >3BHF-A nrPDB Length = 390 Score = 30.9 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 8/38 (21%), Positives = 21/38 (55%), Gaps = 1/38 (2%) Query: 9 CDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGS 45 DV+++G+G+ G++ +LA Q + +++ + Sbjct: 5 FDVIVVGAGSMGMAAGYQLAKQGVKTLLVDAFDPPHTN 42 >3KVE-A nrPDB Length = 486 Score = 30.9 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 19/66 (28%), Positives = 29/66 (43%), Gaps = 7/66 (10%) Query: 5 PEHSCDVLIIGSGAAGLSLALRLADQ-HQVIVLSKGPVTEGSTFY---AQGGIAAVFDET 60 P+H V+++G+G +GLS A LA H+V VL G ++ G A Sbjct: 33 PKH---VVVVGAGMSGLSAAYVLAGAGHKVTVLEASERAGGRVRTHRNSKEGWYANLGPM 89 Query: 61 DSIDSH 66 + H Sbjct: 90 RIPEKH 95 >4B1B-A nrPDB Length = 542 Score = 30.5 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 14/54 (25%), Positives = 25/54 (46%), Gaps = 3/54 (5%) Query: 2 NTLPEHSCDV--LIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGSTFYAQGG 52 N + EH+ D ++IG G G++ A A +V++ + T + GG Sbjct: 34 NKVEEHTYDYDYVVIGGGPGGMASAKEAAAHGARVLLFDYVKPSSQGTKWGIGG 87 >3Q6J-A nrPDB Length = 523 Score = 30.5 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 12/40 (30%), Positives = 18/40 (45%), Gaps = 1/40 (2%) Query: 7 HSCDVLIIGSGAAG-LSLALRLADQHQVIVLSKGPVTEGS 45 D + IG GAAG A A + +++ + P GS Sbjct: 42 REYDAIFIGGGAAGRFGSAYLRAMGGRQLIVDRWPFLGGS 81 >4CBQ-A nrPDB Length = 314 Score = 30.5 bits (67), Expect = 2.1, Method: Composition-based stats. Identities = 16/43 (37%), Positives = 22/43 (51%), Gaps = 3/43 (6%) Query: 10 DVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGG 52 DV+IIGSG A + A+ L V+ +G + G A GG Sbjct: 6 DVVIIGSGPAAHTAAIYLGRSSLKPVMYEGFMAGG---VAAGG 45 >2NVK-X nrPDB Length = 488 Score = 30.5 bits (67), Expect = 2.2, Method: Composition-based stats. Identities = 22/108 (20%), Positives = 33/108 (30%), Gaps = 21/108 (19%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEG-STFYAQGGIAAVFDETDSI 63 + D+++IG G+AGL+ A +V L T T + GG Sbjct: 7 SYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVG----- 61 Query: 64 DSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPN 111 C + AS V G D I+P+ Sbjct: 62 --------------CIPKKLMHQASLLGEAVHEAAAYGWNVDDKIKPD 95 >2RGJ-A nrPDB Length = 402 Score = 30.1 bits (66), Expect = 2.2, Method: Composition-based stats. Identities = 13/40 (32%), Positives = 17/40 (42%), Gaps = 2/40 (5%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQ--HQVIVLSKGPVTE 43 D+LI G+G GLS AL L +V +L Sbjct: 2 SEPIDILIAGAGIGGLSCALALHQAGIGKVTLLESSSEIR 41 >4IWB-A nrPDB Length = 165 Score = 30.1 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 19/70 (27%), Positives = 30/70 (42%), Gaps = 4/70 (5%) Query: 275 TRFMPDFDERGELAPRDIVARAIDHEMKRLGADCMFLDISHKPADFIRQHFPMIYEKLLG 334 R + +D+ EL R ID + A FLD H+ I ++ IY +L Sbjct: 73 ERAIEIYDQVNELEKRKEFVENIDRVYDIISALKSFLD--HEKGKEIAKNLDTIYTIILN 130 Query: 335 --LGIDLTQE 342 + +D T+E Sbjct: 131 TLVKVDKTKE 140 >1ORY-A nrPDB Length = 130 Score = 30.1 bits (66), Expect = 2.3, Method: Composition-based stats. Identities = 19/70 (27%), Positives = 30/70 (42%), Gaps = 4/70 (5%) Query: 275 TRFMPDFDERGELAPRDIVARAIDHEMKRLGADCMFLDISHKPADFIRQHFPMIYEKLLG 334 R + +D+ EL R ID + A FLD H+ I ++ IY +L Sbjct: 34 ERAIEIYDQVNELEKRKEFVENIDRVYDIISALKSFLD--HEKGKEIAKNLDTIYTIILN 91 Query: 335 --LGIDLTQE 342 + +D T+E Sbjct: 92 TLVKVDKTKE 101 >4YNU-A nrPDB Length = 571 Score = 30.1 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 22/107 (20%), Positives = 37/107 (34%), Gaps = 15/107 (14%) Query: 1 MNTLPEHSCDVLIIGSGAAGLSLALRLADQ--HQVIVLSKGPVTEGS-TFYAQGGIAAVF 57 MNT + D +++G G +GL +A RL++ V++L G + G F Sbjct: 1 MNTT---TYDYIVVGGGTSGLVVANRLSENPDVSVLLLEAGASVFNNPDVTNANGYGLAF 57 Query: 58 DETDSIDSHV---------EDTLIAGAGICDRHAVEFVASNARSCVQ 95 + L AG + + +A VQ Sbjct: 58 GSAIDWQYQSINQSYAGGKQQVLRAGKALGGTSTINGMAYTRAEDVQ 104 >5TNX-A nrPDB Length = 383 Score = 30.1 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 25/116 (21%), Positives = 43/116 (37%), Gaps = 4/116 (3%) Query: 15 GSGAAGLSL--ALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDET-DSIDSHVEDTL 71 G+GA G+S A R+A +I + P + + G A+ + D +D+ E T Sbjct: 209 GAGAVGMSAVMAARIAGATTIIAVDIVP-SRLALALELGATHAINSKEVDVVDAIREITG 267 Query: 72 IAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTREGGHSHR 127 + + V S + GV+ + E + GGH+ R Sbjct: 268 GGVDYALESTGLPAVLSQGIDALGSRGTMGVVGAPKLGTKAEFDVNSLLLGGHTIR 323 >4FOI-A nrPDB Length = 917 Score = 30.1 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 17/75 (22%), Positives = 29/75 (38%), Gaps = 2/75 (2%) Query: 242 QFHPTA--LYHPQARNFLLTEALRGEGAYLKRPDGTRFMPDFDERGELAPRDIVARAIDH 299 +FH T L FLL+E+ G+GA + R + E + + + Sbjct: 426 RFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLAHFHLTKDMLL 485 Query: 300 EMKRLGADCMFLDIS 314 E+K+ M L + Sbjct: 486 EVKKRMRAEMELGLR 500 >3AXY-C nrPDB Length = 240 Score = 30.1 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 14/66 (21%), Positives = 24/66 (36%), Gaps = 11/66 (16%) Query: 459 RLERALRRITMLQQEIDEYYAHFRVSNNLLELRNLVQVAELIVRCA-----------MMR 507 +L R + + +++ V +E RNL+ VA V A + Sbjct: 16 KLAEQAERYEEMVEYMEKVAKTVDVEELTVEERNLLSVAYKNVIGARRASWRIVSSIEQK 75 Query: 508 KESRGL 513 +E RG Sbjct: 76 EEGRGN 81 >5TR3-A nrPDB Length = 481 Score = 30.1 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 14/47 (29%), Positives = 21/47 (44%), Gaps = 3/47 (6%) Query: 7 HSCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGSTFYAQGG 52 DV++IG+G G A++ A + + K EG A GG Sbjct: 6 QKFDVVVIGAGPGGYVAAIKAAQLGLKTACIEKYTDAEG--KLALGG 50 >4KQV-A nrPDB Length = 390 Score = 30.1 bits (66), Expect = 2.6, Method: Composition-based stats. Identities = 23/105 (21%), Positives = 41/105 (39%), Gaps = 5/105 (4%) Query: 434 VVIQHNWHELRLFMWDYVGIVRTTKRLERALRRITMLQQEIDEYYAHFRVSNNLLELRNL 493 +V + + L + D VG T ++ R ++ D+ +F+ NLLE + + Sbjct: 138 IVFEDGFKTKDLEIIDNVGKKNTGTKI-----RFWPNKKYFDDIKVNFKALKNLLEAKAI 192 Query: 494 VQVAELIVRCAMMRKESRGLHFTLDYPELLTHSGPSILSPGNHYI 538 + A I ++KE HF L H + P +I Sbjct: 193 LCKALTIKYSNEIKKEKLTWHFETGLKGYLDHKLEAETLPAEPFI 237 >6BZ0-A nrPDB Length = 480 Score = 30.1 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 19/72 (26%), Positives = 28/72 (38%), Gaps = 7/72 (9%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQH-QVIVLSK----GPVTEGSTFYAQGGIAAVFDET 60 D+++IG G G A+R A +V + K G + G T G I + Sbjct: 5 SQQFDLVVIGGGPGGYEAAIRAAQLGFKVACIEKRIHNGKPSLGGTCLNVGCIPSKALLD 64 Query: 61 DSIDSHVEDTLI 72 S EDT+ Sbjct: 65 SSHRY--EDTVH 74 >3K9D-A nrPDB Length = 464 Score = 30.1 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 16/90 (17%), Positives = 30/90 (33%), Gaps = 5/90 (5%) Query: 135 ATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLPGTRRVVGAWVWNRNKETVET 194 G + + AL +LE + G + + ++ Sbjct: 134 KAGNSIVFSPHPNALK----AILETVRIISEAAEKAGCPKGAISCMTVPTIQGTDQLMK- 188 Query: 195 CHAKAVVLATGGASKVYQYTTNPDISSGDG 224 AV+LATGG++ V ++ + G G Sbjct: 189 HKDTAVILATGGSAMVKAAYSSGTPAIGVG 218 >1V59-A nrPDB Length = 478 Score = 30.1 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 13/39 (33%), Positives = 17/39 (43%), Gaps = 1/39 (2%) Query: 7 HSCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEG 44 S DV+IIG G AG A++ A + K G Sbjct: 4 KSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 42 >3FPZ-A nrPDB Length = 326 Score = 30.1 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 12/40 (30%), Positives = 22/40 (55%), Gaps = 3/40 (7%) Query: 10 DVLIIGSGAAGLSLALRLADQH---QVIVLSKGPVTEGST 46 DV+I+G+G++GLS A +A +V ++ G + Sbjct: 67 DVIIVGAGSSGLSAAYVIAKNRPDLKVCIIESSVAPGGGS 106 >2BC1-A nrPDB Length = 490 Score = 30.1 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 15/54 (27%), Positives = 26/54 (48%), Gaps = 7/54 (12%) Query: 355 GGVMVDDHGRTDVEGLYAIGEVSYTGLHGANR------MASNSLLECLVYGWSA 402 G +V+ T + G+YAIG+ + A R +ASN++ +V +A Sbjct: 306 GAFLVNKRQETSIPGVYAIGDCATI-YDNATRDTNYIALASNAVRTGIVAAHNA 358 >1ZOV-A nrPDB Length = 386 Score = 29.7 bits (65), Expect = 2.9, Method: Composition-based stats. Identities = 8/38 (21%), Positives = 20/38 (52%), Gaps = 1/38 (2%) Query: 9 CDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGS 45 DV+++G+G+ G++ LA Q + +++ + Sbjct: 4 FDVIVVGAGSMGMAAGYYLAKQGVKTLLVDSFDPPHTN 41 >1FOH-A nrPDB Length = 664 Score = 29.7 bits (65), Expect = 3.0, Method: Composition-based stats. Identities = 13/24 (54%), Positives = 17/24 (70%) Query: 6 EHSCDVLIIGSGAAGLSLALRLAD 29 E CDVLI+G+G AGL A L++ Sbjct: 5 ESYCDVLIVGAGPAGLMAARVLSE 28 >4EMJ-A nrPDB Length = 410 Score = 29.7 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 14/40 (35%), Positives = 21/40 (52%), Gaps = 4/40 (10%) Query: 356 GVMVDDHGRTDVEGLYAIGEVSYTGLHGANRMASNSLLEC 395 GV+VD G T +G++A+G+V+ L R LE Sbjct: 256 GVIVDHCGATLAKGVFAVGDVASWPL----RAGGRRSLET 291 >1REO-A nrPDB Length = 486 Score = 29.7 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 16/41 (39%), Positives = 23/41 (56%), Gaps = 4/41 (9%) Query: 5 PEHSCDVLIIGSGAAGLSLALRLADQ-HQVIVLSKGPVTEG 44 P+H V+++G+G +GLS A L+ HQV VL G Sbjct: 33 PKH---VVVVGAGMSGLSAAYVLSGAGHQVTVLEASERAGG 70 >3O04-A nrPDB Length = 413 Score = 29.7 bits (65), Expect = 3.7, Method: Composition-based stats. Identities = 17/72 (23%), Positives = 28/72 (38%), Gaps = 13/72 (18%) Query: 28 ADQHQVIVLSKGPVTEGSTFYAQGGIAAVF------DETDSIDSHVEDTLIAGAGICDRH 81 + + + +S G T A GGI A+F D + H L +CD Sbjct: 323 GEHAKKLAISSTKSMTGHTLGASGGIEAIFALLTIRDNIIAPTIH----LKNQDEVCD-- 376 Query: 82 AVEFVASNARSC 93 +++V + AR Sbjct: 377 -LDYVPNEAREA 387 >2VVL-G nrPDB Length = 495 Score = 29.3 bits (64), Expect = 3.8, Method: Composition-based stats. Identities = 10/38 (26%), Positives = 17/38 (44%), Gaps = 1/38 (2%) Query: 10 DVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEGST 46 DV++IG G GL+ L + ++L G + Sbjct: 41 DVIVIGGGYCGLTATRDLTVAGFKTLLLEARDRIGGRS 78 >5J5Z-A nrPDB Length = 496 Score = 29.3 bits (64), Expect = 3.9, Method: Composition-based stats. Identities = 8/27 (29%), Positives = 15/27 (55%) Query: 355 GGVMVDDHGRTDVEGLYAIGEVSYTGL 381 G + V+ +T + +YAIG+V + Sbjct: 322 GRIPVNTRFQTKIPNIYAIGDVVAGPM 348 >4LS7-A nrPDB Length = 426 Score = 29.3 bits (64), Expect = 4.0, Method: Composition-based stats. Identities = 27/148 (18%), Positives = 48/148 (32%), Gaps = 16/148 (10%) Query: 201 VLATGGASKVYQYTTNPDISSGDGIAM---AWRAGCRVANLEFNQFHPTALYHPQARNFL 257 ++ G Y T G AM AG +++ H T+ Y+ + Sbjct: 270 IVGYGSTGDAYHITAPAQDGEGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETM 329 Query: 258 LTEALRGEGAYLKRPDGTRFMPDF---------DERGELAPRDIVARAIDHEMKRLGADC 308 + + GE A+ T+ M LA ++ V ++ +C Sbjct: 330 AIKTVFGEHAHKLAVSSTKSMTGHLLGAAGGIEAIFSILAIKEGVIPP-TINIQTPDEEC 388 Query: 309 MFLDISHKPADFIRQHFPMIYEKLLGLG 336 D+ + P + RQ + LG G Sbjct: 389 ---DLDYVPDEARRQELNYVLSNSLGFG 413 >3KLJ-A nrPDB Length = 385 Score = 29.3 bits (64), Expect = 4.1, Method: Composition-based stats. Identities = 9/22 (40%), Positives = 17/22 (77%) Query: 356 GVMVDDHGRTDVEGLYAIGEVS 377 G++V+DH T ++ +YA G+V+ Sbjct: 246 GILVNDHMETSIKDIYACGDVA 267 >6AON-A nrPDB Length = 478 Score = 29.3 bits (64), Expect = 4.5, Method: Composition-based stats. Identities = 41/228 (17%), Positives = 71/228 (31%), Gaps = 48/228 (21%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGG---------IAAV 56 DV++IG+G G A+R A + A GG A+ Sbjct: 5 SKQFDVVVIGAGPGGYIAAIRAAQLGMSVACIDAWQNGQGGP-APGGTCTNVGCIPSKAL 63 Query: 57 FDETDSIDS---HVE-------------DTLIAGAGICDRHAVEFVASNARSCVQWLIDQ 100 ++ + H DTLI V + +L + Sbjct: 64 LQSSEHYEQANHHFAEHGIEVKGVSLKLDTLIGRKNT--------VVKQNNDGILYLFKK 115 Query: 101 GVLFDTHIQPNGEESYHLTREGGHSHRRILHA-ADATGREVETTLVSKALNHPNIRVLER 159 + H G+ ++ +GG S + AD + V S A P + E+ Sbjct: 116 NKVTYFH----GKGAFAGQVDGGWSIKVTGTTDADLVAKHVIVATGSSARELPGLPFDEK 171 Query: 160 SNAVDLIVSDK----IGLPGTRRVVGAWVWNRNKETV-ETCHAKAVVL 202 +++ +D +P V+GA V +V A+ +L Sbjct: 172 ----NILSNDGALNIGAVPKKLGVIGAGVIGLEMGSVWRRLGAEVTIL 215 >2ZXH-A nrPDB Length = 637 Score = 29.3 bits (64), Expect = 4.6, Method: Composition-based stats. Identities = 49/230 (21%), Positives = 73/230 (31%), Gaps = 60/230 (26%) Query: 8 SCDVLIIGSGAAGLS---LALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDETDSID 64 DV++IG G AG+ A R+ + + VL+ + + S A GGIA Sbjct: 27 EFDVVVIGGGHAGIEAALAAARMGAKTAMFVLNADTIGQMSCNPAIGGIAKGI------- 79 Query: 65 SHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPNGEESYHLTREGGH 124 V+ + G I G + L G Sbjct: 80 ----------------------------VVREIDALGGEMGKAIDQTGIQFKMLNTRKGK 111 Query: 125 SHRRILHAADATGREVETTLVSKALNHPNIRVLERSNAVDLIVSDKIGLPGTRRVVGAWV 184 + + AD + + N N+ + + VD+IV + +VVG Sbjct: 112 AVQSPRAQADK--KRYREYMKKVCENQENLYIKQE-EVVDIIVKN-------NQVVGV-- 159 Query: 185 WNRNKETVETCHAKAVVLATGGASKVYQYTTNPDISSGDGIAMAWRAGCR 234 R VE KAVV+ TG N I GD + R G Sbjct: 160 --RTNLGVEY-KTKAVVVTTGTF-------LNGVIYIGDKMIPGGRLGEP 199 >3URH-A nrPDB Length = 491 Score = 29.3 bits (64), Expect = 4.6, Method: Composition-based stats. Identities = 12/38 (31%), Positives = 20/38 (52%), Gaps = 1/38 (2%) Query: 8 SCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEG 44 + D+++IGSG G A++ A +V V+ K G Sbjct: 25 AYDLIVIGSGPGGYVCAIKAAQLGMKVAVVEKRSTYGG 62 >4YWO-A nrPDB Length = 462 Score = 29.3 bits (64), Expect = 4.7, Method: Composition-based stats. Identities = 25/115 (21%), Positives = 41/115 (35%), Gaps = 23/115 (20%) Query: 278 MPDFDERGELAPRD--------IVARAIDHEMKRLGADCMFLDISHKPADFI---RQHFP 326 +PD++ + R +V E+++ + D AD I P Sbjct: 210 IPDWEPEASVEARRIMENDGVAVVTGVNVKEVRKGAGKIVITDKGEVEADEILLATGRKP 269 Query: 327 MIYEKLLGLGIDLTQEPVPIVPAAHYTCGGVMVDDHGRTDVEGLYAIGEVSYTGL 381 + L G+ L + GG+ VDD RTD +YA G+V + Sbjct: 270 NVDLGLENAGVRLNER------------GGIKVDDELRTDNPHIYAAGDVLGGKM 312 >3RP7-A nrPDB Length = 407 Score = 29.0 bits (63), Expect = 5.0, Method: Composition-based stats. Identities = 8/21 (38%), Positives = 12/21 (57%) Query: 11 VLIIGSGAAGLSLALRLADQH 31 ++IG+G GLS A+ L Sbjct: 26 AIVIGAGIGGLSAAVALKQSG 46 >4HA6-A nrPDB Length = 508 Score = 29.0 bits (63), Expect = 5.2, Method: Composition-based stats. Identities = 11/21 (52%), Positives = 17/21 (80%) Query: 9 CDVLIIGSGAAGLSLALRLAD 29 CD++I+G G+AG LA RL++ Sbjct: 2 CDIVIVGGGSAGSLLAARLSE 22 >4Y4M-A nrPDB Length = 290 Score = 29.0 bits (63), Expect = 5.9, Method: Composition-based stats. Identities = 13/32 (40%), Positives = 22/32 (68%), Gaps = 1/32 (3%) Query: 8 SCDVLIIGSGAAGLSLALRLADQH-QVIVLSK 38 DV+I+G+G +GL+ A LA + +V+VL + Sbjct: 59 EADVVIVGAGPSGLTCARYLAKEGFKVVVLER 90 >2W2A-A nrPDB Length = 194 Score = 29.0 bits (63), Expect = 6.3, Method: Composition-based stats. Identities = 9/53 (16%), Positives = 19/53 (35%) Query: 59 ETDSIDSHVEDTLIAGAGICDRHAVEFVASNARSCVQWLIDQGVLFDTHIQPN 111 ++D + ++AG + D+ A + + + W G PN Sbjct: 48 NDHTVDYRIHGGMVAGRWVTDQKADIVMLTEGIYKISWTEPTGTDVALDFMPN 100 >1PJ5-A nrPDB Length = 830 Score = 28.6 bits (62), Expect = 6.5, Method: Composition-based stats. Identities = 17/45 (37%), Positives = 26/45 (57%), Gaps = 4/45 (8%) Query: 11 VLIIGSGAAGLSLALRLADQH--QVIVLSKGPV--TEGSTFYAQG 51 ++IIG+G G +LA L + + VL +GP+ GST +A G Sbjct: 7 IVIIGAGIVGTNLADELVTRGWNNITVLDQGPLNMPGGSTSHAPG 51 >4JDR-A nrPDB Length = 474 Score = 28.6 bits (62), Expect = 6.6, Method: Composition-based stats. Identities = 12/40 (30%), Positives = 21/40 (52%), Gaps = 1/40 (2%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQH-QVIVLSKGPVTEG 44 E V+++G+G AG S A R AD + +++ + G Sbjct: 4 EIKTQVVVLGAGPAGYSAAFRCADLGLETVIVERYNTLGG 43 >6J0Z-C nrPDB Length = 491 Score = 28.6 bits (62), Expect = 6.8, Method: Composition-based stats. Identities = 15/38 (39%), Positives = 21/38 (55%), Gaps = 3/38 (7%) Query: 10 DVLIIGSGAAGLSLALRLADQH-QVIVLSK--GPVTEG 44 DV+++G+G GL LA L V+VL K P+ E Sbjct: 7 DVVVVGAGPTGLMLAGELRLAGVSVVVLDKLAEPIKES 44 >5UTH-A nrPDB Length = 319 Score = 28.6 bits (62), Expect = 6.9, Method: Composition-based stats. Identities = 11/29 (37%), Positives = 16/29 (55%) Query: 2 NTLPEHSCDVLIIGSGAAGLSLALRLADQ 30 + + DV+IIGSG AG + A+ A Sbjct: 9 MSTSQTVHDVIIIGSGPAGYTAAIYAARA 37 >2A87-A nrPDB Length = 335 Score = 28.6 bits (62), Expect = 7.2, Method: Composition-based stats. Identities = 13/35 (37%), Positives = 19/35 (54%) Query: 10 DVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEG 44 DV++IGSG AG + AL A ++ +G G Sbjct: 16 DVIVIGSGPAGYTAALYAARAQLAPLVFEGTSFGG 50 >1ZEJ-A nrPDB Length = 293 Score = 28.6 bits (62), Expect = 7.7, Method: Composition-based stats. Identities = 9/27 (33%), Positives = 18/27 (66%) Query: 11 VLIIGSGAAGLSLALRLADQHQVIVLS 37 V +IG+G G +A+ +A +H+V++ Sbjct: 15 VFVIGAGLMGRGIAIAIASKHEVVLQD 41 >6BPY-A nrPDB Length = 374 Score = 28.6 bits (62), Expect = 8.0, Method: Composition-based stats. Identities = 19/82 (23%), Positives = 31/82 (37%), Gaps = 10/82 (12%) Query: 9 CDVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDETDSIDSHVE 68 V+IIGSG A + A+ L+ VL +G + G A GG + ++ Sbjct: 5 TKVVIIGSGPAAHTAAIYLSRAELKPVLYEGMLANG---TAAGGQLTTTTDIENFPGF-- 59 Query: 69 DTLIAGAGICDRHAVEFVASNA 90 GI +E + + Sbjct: 60 -----PDGIGGAELMENMRKQS 76 >5U63-A nrPDB Length = 321 Score = 28.2 bits (61), Expect = 9.0, Method: Composition-based stats. Identities = 20/64 (31%), Positives = 28/64 (43%), Gaps = 8/64 (12%) Query: 11 VLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGSTFYAQGGIAAVFDETDSIDSHVEDT 70 +LI+GSG AG + A+ A + VL T QGG DE ++ E T Sbjct: 12 LLILGSGPAGYTAAIYAARANLKPVLV--------TGLQQGGQLTTTDEIENWPGDFEMT 63 Query: 71 LIAG 74 +G Sbjct: 64 TGSG 67 >2VHY-A nrPDB Length = 377 Score = 28.2 bits (61), Expect = 9.8, Method: Composition-based stats. Identities = 8/31 (25%), Positives = 14/31 (45%) Query: 6 EHSCDVLIIGSGAAGLSLALRLADQHQVIVL 36 DV++IG+G AG + A + + Sbjct: 166 VEPADVVVIGAGTAGYNAARIANGMGATVTV 196 >6GAS-A nrPDB Length = 331 Score = 28.2 bits (61), Expect = 10.0, Method: Composition-based stats. Identities = 6/20 (30%), Positives = 14/20 (70%) Query: 357 VMVDDHGRTDVEGLYAIGEV 376 ++V+ T++ G+YA G++ Sbjct: 269 ILVNSKMETNIPGIYAAGDI 288 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.126 0.324 Lambda K H 0.267 0.0389 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 19,165,168 Number of Sequences: 36641 Number of extensions: 734763 Number of successful extensions: 2772 Number of sequences better than 10.0: 169 Number of HSP's better than 10.0 without gapping: 142 Number of HSP's successfully gapped in prelim test: 89 Number of HSP's that attempted gapping in prelim test: 2352 Number of HSP's gapped (non-prelim): 315 length of query: 540 length of database: 10,336,785 effective HSP length: 102 effective length of query: 438 effective length of database: 6,599,403 effective search space: 2890538514 effective search space used: 2890538514 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 61 (28.2 bits)