BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P10613 (528 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5FSA-A nrPDB 999 0.0 5JLC-A nrPDB 701 0.0 4WMZ-A nrPDB 689 0.0 6CR2-A nrPDB 487 e-138 3JUS-A nrPDB 306 2e-83 6AYB-A nrPDB 261 6e-70 2WX2-A nrPDB 217 1e-56 3L4D-A nrPDB 214 9e-56 2X2N-A nrPDB 193 2e-49 2W0A-A nrPDB 182 5e-46 3EL3-A nrPDB 91 1e-18 2VE3-A nrPDB 90 2e-18 6C94-A nrPDB 87 2e-17 5YLW-A nrPDB 77 3e-14 3QZ1-A nrPDB 77 3e-14 3MDV-A nrPDB 76 4e-14 3N9Z-A nrPDB 75 5e-14 5VBU-A nrPDB 75 5e-14 2PG7-A nrPDB 71 1e-12 3MZS-A nrPDB 70 2e-12 3K9V-A nrPDB 69 3e-12 3SN5-A nrPDB 69 4e-12 6DWN-A nrPDB 69 5e-12 6B82-A nrPDB 68 9e-12 4R20-A nrPDB 68 1e-11 4R1Z-A nrPDB 67 2e-11 4GQS-A nrPDB 66 3e-11 3IBD-A nrPDB 66 4e-11 2HI4-A nrPDB 66 4e-11 1N6B-A nrPDB 66 4e-11 5W0C-A nrPDB 62 5e-10 6DA2-A nrPDB 61 1e-09 5VEU-A nrPDB 61 1e-09 5E0E-A nrPDB 60 2e-09 5E58-A nrPDB 59 7e-09 5UYS-A nrPDB 59 7e-09 3DL9-A nrPDB 59 7e-09 3NC3-A nrPDB 55 6e-08 2NNH-A nrPDB 55 6e-08 4H1N-A nrPDB 55 9e-08 3B98-A nrPDB 54 2e-07 5Z9I-A nrPDB 53 3e-07 3S79-A nrPDB 52 8e-07 3E6I-A nrPDB 50 2e-06 6IQ5-A nrPDB 50 2e-06 4KPA-A nrPDB 49 4e-06 3TBG-A nrPDB 49 5e-06 5FYF-A nrPDB 49 6e-06 4WPZ-A nrPDB 49 6e-06 4GGV-A nrPDB 47 2e-05 5L94-A nrPDB 47 3e-05 2VZM-A nrPDB 47 3e-05 2IAG-A nrPDB 46 4e-05 2WIO-A nrPDB 46 4e-05 2XKR-A nrPDB 45 5e-05 1WIY-A nrPDB 44 1e-04 5OFQ-A nrPDB 44 2e-04 1CPT-A nrPDB 44 2e-04 6HQW-A nrPDB 44 2e-04 6A7J-A nrPDB 42 5e-04 4XE3-A nrPDB 42 5e-04 5GWE-A nrPDB 42 8e-04 6A7I-A nrPDB 42 8e-04 5XJN-A nrPDB 42 0.001 4ZGX-A nrPDB 40 0.002 6DCD-A nrPDB 40 0.002 4Z5Q-A nrPDB 40 0.003 5H1Z-A nrPDB 40 0.003 3DBM-A nrPDB 40 0.003 3WVS-A nrPDB 39 0.004 4Z5P-A nrPDB 39 0.004 2FR7-A nrPDB 39 0.004 6M7X-A nrPDB 39 0.004 5IT1-A nrPDB 39 0.005 5VWS-A nrPDB 39 0.005 4TRI-A nrPDB 39 0.005 2Y5N-A nrPDB 38 0.012 1F4U-A nrPDB 38 0.012 3ABA-A nrPDB 38 0.014 4DO1-A nrPDB 37 0.014 4OQS-A nrPDB 37 0.019 1Z8P-A nrPDB 37 0.020 6G5O-A nrPDB 37 0.021 3R9C-A nrPDB 37 0.024 6F0B-A nrPDB 36 0.032 3ABB-A nrPDB 36 0.033 6HQG-A nrPDB 36 0.034 2RFC-A nrPDB 36 0.037 4OQR-A nrPDB 36 0.039 3TYW-A nrPDB 36 0.042 3RWL-A nrPDB 35 0.057 1EHE-A nrPDB 35 0.071 5YSW-A nrPDB 35 0.081 6M7L-A nrPDB 35 0.090 5LIE-A nrPDB 34 0.14 5HDI-A nrPDB 34 0.15 6GII-A nrPDB 34 0.17 3TKT-A nrPDB 33 0.27 4A05-A nrPDB 33 0.27 1GWI-A nrPDB 33 0.32 5XNT-A nrPDB 33 0.42 1UED-A nrPDB 33 0.42 1M6J-A nrPDB 32 0.94 4YZR-A nrPDB 31 1.4 5KYO-A nrPDB 31 1.5 1LG9-A nrPDB 31 1.5 5YHJ-A nrPDB 30 1.8 5IJ6-A nrPDB 30 1.9 2W42-A nrPDB 30 2.2 2ZBZ-A nrPDB 30 2.7 3NV6-A nrPDB 29 4.9 4JBT-A nrPDB 29 5.3 >5FSA-A nrPDB Length = 490 Score = 999 bits (2583), Expect = 0.0, Method: Compositional matrix adjust. Identities = 478/486 (98%), Positives = 480/486 (98%) Query: 43 LRKDRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHE 102 + K PLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHE Sbjct: 1 MAKKTPPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHE 60 Query: 103 FVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKI 162 FVFNAKLSDVSAE+AYKHLTTPVFG GVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKI Sbjct: 61 FVFNAKLSDVSAEEAYKHLTTPVFGTGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKI 120 Query: 163 REEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYS 222 REEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYS Sbjct: 121 REEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYS 180 Query: 223 DLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLI 282 DLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIK RRERGDIDPNRDLIDSLLI Sbjct: 181 DLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKLRRERGDIDPNRDLIDSLLI 240 Query: 283 HSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLK 342 HSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLK Sbjct: 241 HSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLK 300 Query: 343 EKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYV 402 EKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYV Sbjct: 301 EKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYV 360 Query: 403 LVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLP 462 LVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLP Sbjct: 361 LVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLP 420 Query: 463 FGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIWEK 522 FGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIWEK Sbjct: 421 FGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIWEK 480 Query: 523 RETCMF 528 RETCMF Sbjct: 481 RETCMF 486 >5JLC-A nrPDB Length = 515 Score = 701 bits (1809), Expect = 0.0, Method: Compositional matrix adjust. Identities = 332/515 (64%), Positives = 400/515 (77%), Gaps = 9/515 (1%) Query: 11 INYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPLVFYWIPWFGSAASYGQQPYE 70 ++YF +L + Q++SI++ +PFVY + WQ LYSLRKDR PLVFYWIPW GSA YG +PYE Sbjct: 1 LSYFQALPLAQRVSIMVALPFVYTITWQLLYSLRKDRPPLVFYWIPWVGSAIPYGTKPYE 60 Query: 71 FFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGV 130 FFE C++KYGD+FSFMLLG+IMTVYLGPKGHEF+FNAKL+DVSAE AY HLTTPVFGKGV Sbjct: 61 FFEDCQKKYGDIFSFMLLGRIMTVYLGPKGHEFIFNAKLADVSAEAAYSHLTTPVFGKGV 120 Query: 131 IYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMK 190 IYDCPN RLMEQKKF K ALT ++F RYVP I EEI YF ++FK+ E G+ +VM Sbjct: 121 IYDCPNHRLMEQKKFVKGALTKEAFVRYVPLIAEEIYKYFRNSKNFKINENNSGIVDVMV 180 Query: 191 TQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQ 250 +QPE+TIFTASRSL G EMR D FA LYSDLDKGFTPINFVFPNLPL HY +RD AQ Sbjct: 181 SQPEMTIFTASRSLLGKEMRDKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQ 240 Query: 251 KKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQH 310 + IS TYM IK RRE+ DI NRDLID L+ +STYKDG KMTDQEIANLLIG+LMGGQH Sbjct: 241 QAISGTYMSLIKERREKNDIQ-NRDLIDELMKNSTYKDGTKMTDQEIANLLIGVLMGGQH 299 Query: 311 TSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETL 370 TSA+TSAW LLHL E+P +Q+ +YQE + +L D +LTY+DLQ +P +N IKETL Sbjct: 300 TSAATSAWCLLHLAERPDVQEELYQEQMRVL---NNDTKELTYDDLQNMPLLNQMIKETL 356 Query: 371 RMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTA 430 R+H PLHS+FRKV + IP T+Y+VP+ ++VLVSPGY H E +F P +F+ RWD Sbjct: 357 RLHHPLHSLFRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGD 416 Query: 431 AAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYN 490 AA +++ DEVDYGFG +SKGVSSPYLPFGGGRHRCIGE FAY QLG +++ F+ Sbjct: 417 AASSSAA---GGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLMSIFIRT 473 Query: 491 LRWT--IDGYKVPDPDYSSMVVLPTEPAEIIWEKR 523 ++W +G VP D++SMV LPT PA+I WEKR Sbjct: 474 MKWRYPTEGETVPPSDFTSMVTLPTAPAKIYWEKR 508 >4WMZ-A nrPDB Length = 539 Score = 689 bits (1777), Expect = 0.0, Method: Compositional matrix adjust. Identities = 339/521 (65%), Positives = 411/521 (78%), Gaps = 9/521 (1%) Query: 4 VETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPLVFYWIPWFGSAAS 63 +E V G+++FL+L + Q+IS+++ +PF+YN+VWQ LYSLRKDR PLVFYWIPW GSA Sbjct: 12 LEYVNIGLSHFLALPLAQRISLIIIIPFIYNIVWQLLYSLRKDRPPLVFYWIPWVGSAVV 71 Query: 64 YGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTT 123 YG +PYEFFE C++KYGD+FSF+LLG++MTVYLGPKGHEFVFNAKL+DVSAE AY HLTT Sbjct: 72 YGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTT 131 Query: 124 PVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTH 183 PVFGKGVIYDCPNSRLMEQKKF K ALT ++FK YVP I EE+ YF ++F+L E+T Sbjct: 132 PVFGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTT 191 Query: 184 GVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHY 243 G +VM TQPE+TIFTASRSL G EMR D FA LYSDLDKGFTPINFVFPNLPL HY Sbjct: 192 GTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHY 251 Query: 244 WRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIG 303 +RD AQK IS TYM IK RR+ DI +RDLIDSL+ +STYKDGVKMTDQEIANLLIG Sbjct: 252 RKRDHAQKAISGTYMSLIKERRKNNDIQ-DRDLIDSLMKNSTYKDGVKMTDQEIANLLIG 310 Query: 304 ILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVN 363 +LMGGQHTSA+TSAW LLHL E+P +Q +Y+E + +L G +LTY+ LQ++P +N Sbjct: 311 VLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLD---GGKKELTYDLLQEMPLLN 367 Query: 364 NTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFD 423 TIKETLRMH PLHS+FRKV + +P T+Y++P G++VLVSPGY H + YF N F+ Sbjct: 368 QTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFN 427 Query: 424 PTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTI 483 RW+ +A + SV +EVDYGFG +SKGVSSPYLPFGGGRHRCIGE FAY QLG + Sbjct: 428 IHRWNNDSASSYSV----GEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVL 483 Query: 484 LTTFVYNLRWTI-DGYKVPDPDYSSMVVLPTEPAEIIWEKR 523 ++ F+ L+W +G VP PD++SMV LPT PA+IIWEKR Sbjct: 484 MSIFIRTLKWHYPEGKTVPPPDFTSMVTLPTGPAKIIWEKR 524 >6CR2-A nrPDB Length = 477 Score = 487 bits (1253), Expect = e-138, Method: Compositional matrix adjust. Identities = 242/486 (49%), Positives = 331/486 (68%), Gaps = 17/486 (3%) Query: 43 LRKDRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHE 102 + K P+VF+W P+ GS SYG PY+FF CR KYGD+F+F+LLGK TVYLG KG++ Sbjct: 1 MAKKTPPVVFHWFPFIGSTISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTVYLGTKGND 60 Query: 103 FVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKI 162 F+ N KL DV AE+ Y LTTPVFG+ V+YDCPN++LMEQKKF K+ LT+D+ + YVP I Sbjct: 61 FILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQKKFVKYGLTSDALRSYVPLI 120 Query: 163 REEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYS 222 +E+ ++ +F+ + GV +V KT EITI+TASRSL G E+R FD +FA+LY Sbjct: 121 TDEVESFVKNSPAFQGHK---GVFDVCKTIAEITIYTASRSLQGKEVRSKFDSTFAELYH 177 Query: 223 DLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLI 282 +LD GF PINF+ P PLPH +RDAAQ+K++ TYM+ IK+RR+ G + D++ +L+ Sbjct: 178 NLDMGFAPINFMLPWAPLPHNRKRDAAQRKLTETYMEIIKARRQAGSKKDSEDMVWNLM- 236 Query: 283 HSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLK 342 YK+G + D+EIA+++I +LM GQH+S+ST++W +L L +P + + +YQE + +L Sbjct: 237 SCVYKNGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVL- 295 Query: 343 EKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYV 402 G DL LTY++LQKL IKETLR+H P+HSI R V NP+ + T+Y++P H V Sbjct: 296 --GSDLPPLTYDNLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSHNV 353 Query: 403 LVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLP 462 L SPG SE +F NP +++P RWD A S ++VDYG+G VSKG +SPYLP Sbjct: 354 LSSPGVTARSEEHFPNPLEWNPHRWDENIA----ASAEDDEKVDYGYGLVSKGTNSPYLP 409 Query: 463 FGGGRHRCIGEQFAYVQLGTILTTFVYNLRWT----IDGYKVPDPDYSSMVVLPTEPAEI 518 FG GRHRCIGEQFAY+QLGTI V R+ +DG +PD DYSS+ P + + Sbjct: 410 FGAGRHRCIGEQFAYLQLGTITAVLVRLFRFRNLPGVDG--IPDTDYSSLFSKPLGRSFV 467 Query: 519 IWEKRE 524 +EKR Sbjct: 468 EFEKRH 473 >3JUS-A nrPDB Length = 461 Score = 306 bits (783), Expect = 2e-83, Method: Compositional matrix adjust. Identities = 190/480 (39%), Positives = 262/480 (54%), Gaps = 41/480 (8%) Query: 49 PLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAK 108 P +F IP+ G A ++G+ P EF E+ +KYG VFSF ++GK T LG +FN+K Sbjct: 14 PYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSK 73 Query: 109 LSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILN 168 D++AED Y LTTPVFGKGV YD PN +EQKK K L FK++V I +E Sbjct: 74 NEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKE 133 Query: 169 YFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGF 228 YF ES+ G NV + E+ I TAS L G E+R + AQLY+DLD GF Sbjct: 134 YF---ESW----GESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGF 186 Query: 229 TPINFVFPN-LPLPHYWRRDAAQKKISATYMKEIKSRRERGD-IDPNRDLIDSLLIHSTY 286 + ++ P LPLP + RRD A ++I + K I+ RR+ + ID D++ +LL +TY Sbjct: 187 SHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKID---DILQTLL-DATY 242 Query: 287 KDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGG 346 KDG +TD E+A +LIG+L+ GQHTS++TSAW L LQ Y E + G Sbjct: 243 KDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVC---GE 299 Query: 347 DLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSP 406 +L LTY+ L+ L ++ IKETLR+ P+ + R P + Y +P GH V VSP Sbjct: 300 NLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTV--AGYTIPPGHQVCVSP 357 Query: 407 GYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGG 466 + + DF+P R+ + N S G Y+PFG G Sbjct: 358 TVNQRLKDSWVERLDFNPDRY----LQDNPAS----------------GEKFAYVPFGAG 397 Query: 467 RHRCIGEQFAYVQLGTILTTFVYNLRW-TIDGYKVPDPDYSSMVVLPTEPAEIIWEKRET 525 RHRCIGE FAYVQ+ TI +T + + IDGY P +Y++M+ P P I +++R T Sbjct: 398 RHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGY-FPTVNYTTMIHTPENPV-IRYKRRST 455 >6AYB-A nrPDB Length = 466 Score = 261 bits (667), Expect = 6e-70, Method: Compositional matrix adjust. Identities = 165/486 (33%), Positives = 257/486 (52%), Gaps = 50/486 (10%) Query: 49 PLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAK 108 P V IP+ GS S+ + P +F +KYGDVF+ +LGK MT PK + F A Sbjct: 13 PRVPNLIPYVGSFVSFAKNPVQFIIDNSKKYGDVFTATILGKEMTFLNHPKILDTFFKAT 72 Query: 109 LSDVSAEDAYKHLTTPVFGKGVIYDCPNS-RLMEQKKFAKFALTTDSFKRYVPKIREEIL 167 +++S D Y+ + PVFG GV+YD ++ R+MEQ KF LTT F+ +V +EI Sbjct: 73 DNELSLRDVYRFM-RPVFGTGVVYDADSTERMMEQVKFVSSGLTTARFRVFVDIFEDEI- 130 Query: 168 NYFVTDESFKLKE-KTHGVANVMKTQPEITIFTASRSLFGDEMRR-IFDRSFAQLYSDLD 225 + K+KE G +V + ++ IFTASR L GDE+R+ + +++ +LY D+D Sbjct: 131 -------AHKVKELGPEGTVDVAELMADLIIFTASRCLLGDEVRQYLSEKNLGKLYHDID 183 Query: 226 KGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNR-------DLID 278 G +P++F +P+LP P +RD A+K + + + + RRE P R D++D Sbjct: 184 DGISPLSFFYPSLPAP---KRDKARKAVGEIFQELLDKRREEHKKHPERLLDESKMDVVD 240 Query: 279 SLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVV 338 LL YKDG ++TD +LI L GQHTS+ TS+W L+++ + + + +E Sbjct: 241 HLLTQK-YKDGQELTDVHRIGILIAGLFAGQHTSSITSSWTLMNVISNKKVLEKVRKEQE 299 Query: 339 ELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPK 398 E++ G L Y+ + K+ + +KE LRM+ PL I R P + YI+PK Sbjct: 300 EIM----GSDKVLDYDKVMKMDYLEACMKEALRMYPPLIMIMRMARKPRECEQ--YIIPK 353 Query: 399 GHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSS 458 G+ ++VSP A + NP+ FDP R + + +G V Sbjct: 354 GNILVVSPSVAGRCTDTYTNPDVFDPERLT-----------ERKEHEKFKYGAV------ 396 Query: 459 PYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEI 518 PFG GRH+CIGE FA +Q+ +I++ + G K+PDP Y+S+VV P+ P + Sbjct: 397 ---PFGAGRHKCIGENFALLQVKSIISILLRYFDMEYIG-KIPDPSYTSLVVGPSPPTRM 452 Query: 519 IWEKRE 524 ++ R+ Sbjct: 453 RYKLRK 458 >2WX2-A nrPDB Length = 473 Score = 217 bits (552), Expect = 1e-56, Method: Compositional matrix adjust. Identities = 141/469 (30%), Positives = 236/469 (50%), Gaps = 52/469 (11%) Query: 55 IPWFGSAASYGQQPYEFFESCRQKY-GDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVS 113 +P+ G +G+ P EF + C++ VF+ + G+ +T+ P H F+ + +S Sbjct: 25 VPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSRFFSPRNEILS 84 Query: 114 AEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTD 173 + Y + TPVFG+GV Y P R+ EQ F LT F+ +VP I+ E+ + Sbjct: 85 PREVYT-IMTPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMA-- 141 Query: 174 ESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMR-RIFDRSFAQLYSDLDKGFTPIN 232 E++K E GV N+++ + I TA + LFG+++R R+ R FAQL S ++ P Sbjct: 142 ENWKEDE---GVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSKMESSLIPAA 198 Query: 233 FVFP---NLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSL--LIHSTYK 287 P LPLP R A+ ++ + EI RE+ + + + D L L+ + Y+ Sbjct: 199 VFMPWLLRLPLPQSARCREARAELQKI-LGEIIVAREKEEASKDNNTSDLLGGLLKAVYR 257 Query: 288 DGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQ--DVIYQEVVELLKEKG 345 DG +M+ E+ +++ + GQHTS T++W +LHL + + D +++E+ E + Sbjct: 258 DGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEFPAQ-- 315 Query: 346 GDLNDLTYED-LQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLV 404 L Y++ + ++P ++E++R PL + R V +++ +Y+VPKG + Sbjct: 316 -----LNYDNVMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKV--GSYVVPKGDIIAC 368 Query: 405 SPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFG 464 SP +H E F NP +DP R ++VD F + FG Sbjct: 369 SPLLSHHDEEAFPNPRLWDPER---------------DEKVDGAF-----------IGFG 402 Query: 465 GGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPT 513 G H+CIG++FA +Q+ TIL T + + +VPDPDY +MVV PT Sbjct: 403 AGVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVGPT 451 >3L4D-A nrPDB Length = 453 Score = 214 bits (544), Expect = 9e-56, Method: Compositional matrix adjust. Identities = 136/474 (28%), Positives = 229/474 (48%), Gaps = 51/474 (10%) Query: 49 PLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAK 108 P+V P+ G +G+ P F ++KYG +F+ + G +TV H F + Sbjct: 6 PVVHGTTPFVGHIIQFGKDPLGFMLKAKKKYGGIFTMNICGNRITVVGDVHQHSKFFTPR 65 Query: 109 LSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILN 168 +S + Y + PVFG+GV Y P R+ EQ F LT F+ + P I+ E+ Sbjct: 66 NEILSPREVYSFMV-PVFGEGVAYAAPYPRMREQLNFLAEELTVAKFQNFAPSIQHEVRK 124 Query: 169 YFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFD-RSFAQLYSDLDKG 227 + + + K G N++ + I TA + LFG+++R+ D R FAQL + ++ Sbjct: 125 FMKANWN-----KDEGEINILDDCSAMIINTACQCLFGEDLRKRLDARQFAQLLAKMESC 179 Query: 228 FTPINFVFP---NLPLPHYWRRDAAQKKISATYMKEIKSR-RERGDIDPNRDLIDSLLIH 283 P P LPLP +R A+ ++ + I +R +E D N + + L+ Sbjct: 180 LIPAAVFLPWILKLPLPQSYRCRDARAELQDILSEIIIAREKEEAQKDTNTSDLLAGLLG 239 Query: 284 STYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGE---KPHLQDVIYQEVVEL 340 + Y+DG +M+ E+ +++ + GQHTS T+ W LLHL + K HL ++QE+ E Sbjct: 240 AVYRDGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAK-LHQEIDEF 298 Query: 341 LKEKGGDLNDLTYED-LQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKG 399 + L Y++ ++++P +E++R PL + RKV P+++ Y+VP+G Sbjct: 299 PAQ-------LNYDNVMEEMPFAEQCARESIRRDPPLVMLMRKVLKPVQV--GKYVVPEG 349 Query: 400 HYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSP 459 + SP +H E F NP +++P R K V Sbjct: 350 DIIACSPLLSHQDEEAFPNPREWNPERN-------------------------MKLVDGA 384 Query: 460 YLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPT 513 + FG G H+CIGE+F +Q+ T+L T + + + + G +P+P+Y +MVV PT Sbjct: 385 FCGFGAGVHKCIGEKFGLLQVKTVLATVLRDYDFELLG-PLPEPNYHTMVVGPT 437 >2X2N-A nrPDB Length = 475 Score = 193 bits (490), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 135/473 (28%), Positives = 221/473 (46%), Gaps = 48/473 (10%) Query: 49 PLVFYWIPWFGSAASYGQQPYEFFESC-RQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNA 107 P+ +P G +G+ P F + C RQ +F+ ++GK +T+ P H F Sbjct: 19 PVYPVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEHSRFFLP 78 Query: 108 KLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEIL 167 + +S + Y + PVFG+GV Y P R+ EQ F LT F+ +VP I+ E+ Sbjct: 79 RNEVLSPREVYSFMV-PVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVR 137 Query: 168 NYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFD-RSFAQLYSDLDK 226 + + +K G N+++ + I TA + LFG+++R+ D R FAQL + ++ Sbjct: 138 KFMAAN-----WDKDEGEINLLEDCSTMIINTACQCLFGEDLRKRLDARRFAQLLAKMES 192 Query: 227 GFTPINFVFPNLPLPHYWRRDAAQKKISATYMK---EIKSRRERGDIDPNRDLIDSL--L 281 P VF + L + A + K EI R+ ++ + D L L Sbjct: 193 SLIPAA-VFLPILLKLPLPQSARCHEARTELQKILSEIIIARKAAAVNKDSSTSDLLSGL 251 Query: 282 IHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELL 341 + + Y+DG M+ E+ +++ + GQHTS+ T+ W +LHL H +V + E L Sbjct: 252 LSAVYRDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLM---HPANVKHLEA--LR 306 Query: 342 KEKGGDLNDLTYED-LQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGH 400 KE L Y + + ++P +E++R PL + RKV +++ +Y+VPKG Sbjct: 307 KEIEEFPAQLNYNNVMDEMPFAERCARESIRRDPPLLMLMRKVMADVKV--GSYVVPKGD 364 Query: 401 YVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPY 460 + SP +H E F P +DP R + V + Sbjct: 365 IIACSPLLSHHDEEAFPEPRRWDPER--------------------------DEKVEGAF 398 Query: 461 LPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPT 513 + FG G H+CIG++F +Q+ TIL T + + + +VPDPDY +MVV PT Sbjct: 399 IGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQLLRDEVPDPDYHTMVVGPT 451 >2W0A-A nrPDB Length = 455 Score = 182 bits (461), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 126/470 (26%), Positives = 216/470 (45%), Gaps = 43/470 (9%) Query: 59 GSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAY 118 G + P + R + GDV +F L GK + + G +EF F A D+ AY Sbjct: 17 GHLEEFRTDPIGLMQRVRDELGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAY 76 Query: 119 KHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKL 178 +T P+FG+ V++D R E A AL + K + I +++ + D Sbjct: 77 PFMT-PIFGEAVVFDASPERRKEMLHNA--ALRGEQMKGHAATIEDQV-RRMIADWG--- 129 Query: 179 KEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNL 238 G +++ E+TI+T+S L G + R D FA+LY +L++G P+ +V P L Sbjct: 130 ---EAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYL 186 Query: 239 PLPHYWRRDAAQKKISATYMKEIKSRRERGDID-PNRDLIDSLLIHSTYKDGVKMTDQEI 297 P+ + RRD A+ + A + R D +RD++D L+ + + EI Sbjct: 187 PIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEI 246 Query: 298 ANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQ 357 + I ++ G HTS+ T++W L+ L +D Y V++ L E GD +++ L+ Sbjct: 247 TGMFISMMFAGHHTSSGTASWTLIELMRH---RDA-YAAVIDELDELYGDGRSVSFHALR 302 Query: 358 KLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFD 417 ++P + N +KETLR+H PL + R + + + +G V SP ++ F Sbjct: 303 QIPQLENVLKETLRLHPPLIILMRVAKGEFEV--QGHRIHEGDLVAASPAISNRIPEDFP 360 Query: 418 NPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAY 477 +P DF P R++ + + ++PFG GRHRC+G FA Sbjct: 361 DPHDFVPARYEQPRQEDLLNRWT-------------------WIPFGAGRHRCVGAAFAI 401 Query: 478 VQLGTILTTFVYNLRWTI----DGYKVPDPDYSSMVVLPTEPAEIIWEKR 523 +Q+ I + + + + + Y+ D+S MVV +PA + + +R Sbjct: 402 MQIKAIFSVLLREYEFEMAQPPESYR---NDHSKMVVQLAQPAAVRYRRR 448 >3EL3-A nrPDB Length = 467 Score = 90.9 bits (224), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 100/453 (22%), Positives = 173/453 (38%), Gaps = 52/453 (11%) Query: 49 PLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAK 108 P+ +P G + P F R +GDV + + LGPK V N + Sbjct: 25 PVAGGGVPLLGHGWRLARDPLAFMSQLRD-HGDV---------VRIKLGPKTVYAVTNPE 74 Query: 109 LSDVSAEDAYKHLTTPV-------FGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPK 161 L+ A + H+ P+ GK + Q++ + A D+ Y P Sbjct: 75 LTGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPI 134 Query: 162 IREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLY 221 + EE E ++ + + + + R + DE + A ++ Sbjct: 135 MEEEA---HALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVF 191 Query: 222 SDL-DKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSL 280 + + P+ ++ LPLP R + A + + I RR G P+ DL+ +L Sbjct: 192 RGMYRRMVVPLGPLY-RLPLPANRRFNDALADLHLLVDEIIAERRASGQ-KPD-DLLTAL 248 Query: 281 LIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVEL 340 L + +G + +QEI + ++ IL G T AST W L L + P D I EV + Sbjct: 249 L-EAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAV 307 Query: 341 LKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGH 400 GG + +ED++KL N I E +R+ + + R+ + Y +P G Sbjct: 308 ---TGG--RPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESEL--GGYRIPAGA 360 Query: 401 YVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPY 460 ++ SP + +D+ +FDP RW + +++ Y Sbjct: 361 DIIYSPYAIQRDPKSYDDNLEFDPDRW---------LPERAANVPKYAMK---------- 401 Query: 461 LPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRW 493 PF G+ +C + F+ QL I R+ Sbjct: 402 -PFSAGKRKCPSDHFSMAQLTLITAALATKYRF 433 >2VE3-A nrPDB Length = 444 Score = 90.1 bits (222), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 93/448 (20%), Positives = 185/448 (41%), Gaps = 54/448 (12%) Query: 53 YWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDV 112 + +PW G ++ +F + +Q++G +F L GK + G + F+F + Sbjct: 18 FGLPWLGETLNFLND-GDFGKKRQQQFGPIFKTRLFGKNVIFISGALANRFLFTKEQETF 76 Query: 113 SAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVT 172 A + T + G + ++K A + Y+PK+ + Y Sbjct: 77 QA--TWPLSTRILLGPNALATQMGEIHRSRRKILYQAFLPRTLDSYLPKMDGIVQGYL-- 132 Query: 173 DESFKLKEKTHGVANVMKTQPEI--TIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFT- 229 + G AN + P++ F + +LF E + F + + F+ Sbjct: 133 --------EQWGKANEVIWYPQLRRMTFDVAATLFMGEKVSQNPQLFPWFETYIQGLFSL 184 Query: 230 PINFVFPNLPLPH--YWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYK 287 PI PLP+ + + A+ + A K IK+R+++ P+ + +L+ + Sbjct: 185 PI-------PLPNTLFGKSQRARALLLAELEKIIKARQQQ---PPSEEDALGILLAARDD 234 Query: 288 DGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGD 347 + ++ E+ + ++ +L G T S + F L LG+ +++ + QE +L + Sbjct: 235 NNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQEQNKLQLSQ--- 291 Query: 348 LNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPG 407 +LT E L+K+P ++ ++E LR+ P+ FR++ + + PKG V Sbjct: 292 --ELTAETLKKMPYLDQVLQEVLRLIPPVGGGFRELIQDCQF--QGFHFPKGWLVSYQIS 347 Query: 408 YAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGR 467 H + +PE FDP R+ + ++ F ++PFGGG Sbjct: 348 QTHADPDLYPDPEKFDPERFTPDGSATHNPPFA-------------------HVPFGGGL 388 Query: 468 HRCIGEQFAYVQLGTILTTFVYNLRWTI 495 C+G++FA +++ T + WT+ Sbjct: 389 RECLGKEFARLEMKLFATRLIQQFDWTL 416 >6C94-A nrPDB Length = 497 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 59/243 (24%), Positives = 111/243 (45%), Gaps = 28/243 (11%) Query: 261 IKSRRERGDIDPNR--DLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAW 318 ++ +ER I R D +D +L+ + GV+++D ++ + + G T+ S +W Sbjct: 246 LQDEKEREKIQNRRHLDFLD-ILLDVRGESGVQLSDTDLRAEVDTFMFEGHDTTTSGISW 304 Query: 319 FLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHS 378 FL + P Q +EV E+L GD + +EDL K+ + +KE R++ P+ Sbjct: 305 FLYCMALYPEHQQRCREEVREIL----GDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQ 360 Query: 379 IFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVS 438 ++R+++ P+ + + P G + + H + + +PE FDP R+ Sbjct: 361 VYRQLSKPVSFVDGRSL-PAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPE-------- 411 Query: 439 FNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGY 498 NSS Y F +PF G CIG+QFA ++ + + +++D Sbjct: 412 -NSSGRHPYAF-----------IPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSVDPL 459 Query: 499 KVP 501 ++P Sbjct: 460 RLP 462 >5YLW-A nrPDB Length = 495 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 110/517 (21%), Positives = 194/517 (37%), Gaps = 85/517 (16%) Query: 26 LLGVPFVYNLVWQYLYSLRKDRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSF 85 LL F +L R+ P + P G+ G P++ F ++YG + S Sbjct: 6 LLAALFFIAATITFLSFRRRRNLPPGPFPYPIVGNMLQLGANPHQVFAKLSKRYGPLMSI 65 Query: 86 MLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVF-GKGV---IYDCPNSRL-- 139 L G + TV + +++ E ++H VF G+ + ++ C + ++ Sbjct: 66 HL-GSLYTVIVSS-----------PEMAKEILHRH--GQVFSGRTIAQAVHACDHDKISM 111 Query: 140 ---------MEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMK 190 + +K K + ++ +R + L + D K + V ++ + Sbjct: 112 GFLPVASEWRDMRKICKEQMFSNQSMEASQGLRRQKLQQLL-DHVQKCSDSGRAV-DIRE 169 Query: 191 TQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPI----NFV--FPNL----PL 240 T+ S +LF + FD + ++ +G I NF FP L P Sbjct: 170 AAFITTLNLMSATLFSSQATE-FDSKATMEFKEIIEGVATIVGVPNFADYFPILRPFDPQ 228 Query: 241 PHYWRRDAAQKKISATYMKEIKSRRERGDIDPN---RDLIDSLLIHSTYKDGVKMTDQEI 297 R D K+ A + R E +PN +D +++ + K+ Sbjct: 229 GVKRRADVFFGKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDIIQANEFKLKTHHF 288 Query: 298 ANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQ 357 +L++ + +GG T+ ++ W + L P + E LK GD + + Sbjct: 289 THLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAE----LKSVAGDEKIVDESAMP 344 Query: 358 KLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIP-------ETN-YIVPKGHYVLVSPGYA 409 KLP + IKE +R+H P PL +P E N Y++PKG +L++ Sbjct: 345 KLPYLQAVIKEVMRIHPP---------GPLLLPRKAESDQEVNGYLIPKGTQILINAYAI 395 Query: 410 HTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHR 469 + +PE FDP R+ +++D+ KG LPFG GR Sbjct: 396 GRDPSIWTDPETFDPERF-------------LDNKIDF------KGQDYELLPFGSGRRV 436 Query: 470 CIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYS 506 C G A L T V+N W ++ D++ Sbjct: 437 CPGMPLATRILHMATATLVHNFDWKLEDDSTAAADHA 473 >3QZ1-A nrPDB Length = 496 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 66/267 (24%), Positives = 115/267 (43%), Gaps = 37/267 (13%) Query: 228 FTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLI---HS 284 P FPN P WR A + K+++ +E RD+ D +L Sbjct: 210 MVPFLRFFPN---PGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDMTDYMLQGVGRQ 266 Query: 285 TYKDGV-KMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKE 343 ++G ++ + + ++ + +GG T+AST +W + L P +Q + +E+ L Sbjct: 267 RVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEELDRELG- 325 Query: 344 KGGDLNDLTYEDLQKLPSVNNTIKETLRMH--MPLHSIFRKVTNPLRIPETNYIVPKGHY 401 G + +TY+D +LP +N TI E LR+ +PL ++ + T P I Y +P+G Sbjct: 326 PGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPL-ALPHRTTRPSSI--FGYDIPEGMV 382 Query: 402 VLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYL 461 V+ + AH E ++ P +F P R+ + G + L Sbjct: 383 VIPNLQGAHLDETVWEQPHEFRPDRF------------------------LEPGANPSAL 418 Query: 462 PFGGGRHRCIGEQFAYVQLGTILTTFV 488 FG G C+GE A ++L +L + Sbjct: 419 AFGCGARVCLGESLARLELFVVLARLL 445 >3MDV-A nrPDB Length = 456 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 94/438 (21%), Positives = 176/438 (40%), Gaps = 63/438 (14%) Query: 77 QKYGDVFSFMLLGKIMTVYLGPKG-HEFVFNAKLSDVSAEDAYKHLTT----PVFGKGVI 131 +KYG V + K + P+ +F+ + K + S Y+ L T +FG+G++ Sbjct: 21 KKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDS--KMYRALQTVFGERLFGQGLV 78 Query: 132 YDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKT 191 +C R +Q++ A + S + E+ L+ K G V + Sbjct: 79 SECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEI-----LEAKADGQTPV--S 131 Query: 192 QPEITIFTA----SRSLFGDEMRRIF--DRSFAQLYSDLDKGFTPINFVFPNLPLPHYWR 245 ++ +TA +++ FG E + + +Q + +G T LP R Sbjct: 132 MQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKF-LPGK-R 189 Query: 246 RDAAQKKISATYMKEI-----KSRRE---RGDIDPNRDLIDSLLIHSTYKDGVKMTDQEI 297 + + + S +++++ + RRE RG+ P L L +D D+ + Sbjct: 190 KQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQD-----DEGL 244 Query: 298 ANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQ 357 + + + G TSA+ A+ ++ L +P + + EV E++ G L +EDL Sbjct: 245 LDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVI----GSKRYLDFEDLG 300 Query: 358 KLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFD 417 +L ++ +KE+LR++ P FR + I VP +L S + YF+ Sbjct: 301 RLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVR--VPGNTPLLFSTYVMGRMDTYFE 358 Query: 418 NPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAY 477 +P F+P R+ A K Y PF G CIG+QFA Sbjct: 359 DPLTFNPDRFGPGAPKPRFT----------------------YFPFSLGHRSCIGQQFAQ 396 Query: 478 VQLGTILTTFVYNLRWTI 495 +++ ++ + L + + Sbjct: 397 MEVKVVMAKLLQRLEFRL 414 >3N9Z-A nrPDB Length = 487 Score = 75.5 bits (184), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 56/225 (24%), Positives = 106/225 (47%), Gaps = 28/225 (12%) Query: 291 KMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLND 350 KM+ ++I + +L GG T++ T W L + +QD++ EV+ + GD+ Sbjct: 270 KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMAT 329 Query: 351 LTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAH 410 + LQ +P + +IKETLR+H ++ R + N L + +Y++P V V+ Sbjct: 330 M----LQLVPLLKASIKETLRLHPISVTLQRYLVNDLVL--RDYMIPAKTLVQVAIYALG 383 Query: 411 TSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRC 470 +F +PE+FDPTRW +K ++++ + L FG G +C Sbjct: 384 REPTFFFDPENFDPTRW---LSKDKNITYFRN------------------LGFGWGVRQC 422 Query: 471 IGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEP 515 +G + A +++ L + N R I + +++++P +P Sbjct: 423 LGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTF-NLILMPEKP 466 >5VBU-A nrPDB Length = 476 Score = 75.5 bits (184), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 71/297 (23%), Positives = 131/297 (44%), Gaps = 39/297 (13%) Query: 235 FPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLL---IHSTYKDGV- 290 FPN P R A +K +++ +E RD++D +L + ++G Sbjct: 200 FPN---PGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSG 256 Query: 291 KMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLND 350 ++ + + + +L+GG T+A+T +W ++ L P +Q + +E+ L G + Sbjct: 257 QLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELG-PGASSSR 315 Query: 351 LTYEDLQKLPSVNNTIKETLRMH--MPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGY 408 + Y+D +LP +N TI E LR+ +PL ++ + T P I + Y +P+G ++ + Sbjct: 316 VPYKDRARLPLLNATIAEVLRLRPVVPL-ALPHRTTRPSSI--SGYDIPEGTVIIPNLQG 372 Query: 409 AHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRH 468 AH E ++ P +F P R+ + G +S L FG G Sbjct: 373 AHLDETVWERPHEFWPDRF------------------------LEPGKNSRALAFGCGAR 408 Query: 469 RCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVP--DPDYSSMVVLPTEPAEIIWEKR 523 C+GE A ++L +LT + G +P P V+L +P ++ + R Sbjct: 409 VCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPR 465 >2PG7-A nrPDB Length = 476 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 60/230 (26%), Positives = 102/230 (44%), Gaps = 34/230 (14%) Query: 270 IDPN--RDLIDSLLIHSTYKDGVKMTDQEIANLLIGIL---MGGQHTSASTSAWFLLHLG 324 +DPN RD IDS LI ++ T+ + NL++ L +GG T ++T + L L Sbjct: 237 LDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLM 296 Query: 325 EKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMH--MPLHSIFRK 382 + P ++ +++E+ ++ G +ED K+P + I E R +P+ S+ R+ Sbjct: 297 KHPEVEAKVHEEIDRVI----GKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPM-SLARR 351 Query: 383 VTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSS 442 V + ++ +PKG V G +F NP+DF+P + + F S Sbjct: 352 VKKDTKF--RDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQ-----FKKS 404 Query: 443 DEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLR 492 D ++PF G+ C GE A ++L TT + N R Sbjct: 405 DA---------------FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFR 439 >3MZS-A nrPDB Length = 486 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 54/236 (22%), Positives = 112/236 (47%), Gaps = 40/236 (16%) Query: 291 KMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLND 350 KM +++ + +L GG +T++ T W L + ++Q+++ +EV+ ++ GD++ Sbjct: 271 KMLLEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISK 330 Query: 351 LTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPET-----NYIVPKGHYVLVS 405 + LQ +P + +IKETLR+H P+ + R PE+ +Y++P V V+ Sbjct: 331 M----LQMVPLLKASIKETLRLH-PISVTLQ------RYPESDLVLQDYLIPAKTLVQVA 379 Query: 406 PGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGG 465 +F +P+ FDPTRW + + + F + L FG Sbjct: 380 IYAMGRDPAFFSSPDKFDPTRW--LSKDKDLIHFRN-------------------LGFGW 418 Query: 466 GRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPD-YSSMVVLPTEPAEIIW 520 G +C+G + A +++ L + N + ++ + D D ++++ P +P +++ Sbjct: 419 GVRQCVGRRIAELEMTLFLIHILENFK--VEMQHIGDVDTIFNLILTPDKPIFLVF 472 >3K9V-A nrPDB Length = 482 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 55/228 (24%), Positives = 93/228 (40%), Gaps = 42/228 (18%) Query: 292 MTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDL 351 ++ +E+ + + + T+A++ W L +L P Q + QEV +L D Sbjct: 279 LSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLP----DNQTP 334 Query: 352 TYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHT 411 EDL+ +P + +KE++R+ + R + P + E Y +PKG + ++ + Sbjct: 335 RAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVLGE--YALPKGTVLTLNTQVLGS 392 Query: 412 SERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCI 471 SE F++ F P RW K N + +LPFG G+ CI Sbjct: 393 SEDNFEDSHKFRPERWLQKEKKINPFA---------------------HLPFGIGKRMCI 431 Query: 472 GEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEII 519 G + A +QL L W I Y + V EP E++ Sbjct: 432 GRRLAELQLHLALC-------WIIQKYDI--------VATDNEPVEML 464 >3SN5-A nrPDB Length = 491 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 105/488 (21%), Positives = 192/488 (39%), Gaps = 54/488 (11%) Query: 49 PLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKG-HEFVFNA 107 PL IP+ G A +G P EF + ++K+G VF+ L+GK + P H+ + + Sbjct: 16 PLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHG 75 Query: 108 KLSD------VSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPK 161 K D + A+ H + + ++ + + A +LT + Sbjct: 76 KYFDWKKFHFALSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENL--- 132 Query: 162 IREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTAS-RSLFGDEMRRIFDRSFAQL 220 + I+ V+ S T G+ + +F A ++FG ++ R D A + Sbjct: 133 --QRIMRPPVSSNSKTAAWVTEGMYSFCYR----VMFEAGYLTIFGRDLTRR-DTQKAHI 185 Query: 221 YSDLDKGFTPINFVFP----NLPLPHYWRRDAAQKKISATYMKEIKSRRER-GDIDPNRD 275 ++LD F + VFP LP+ + A++K++ + E +RE ++ R Sbjct: 186 LNNLD-NFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRM 244 Query: 276 LIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQ 335 ++ L ST+ D E A + +L Q + + W L + P + Sbjct: 245 FLNDTL--STFDD------LEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATE 296 Query: 336 EVVELLKEKG------GDLNDLTYEDLQKLPSVNNTIKETLRMH-MPLHSIFRKVTNPLR 388 EV L+ G G+ L+ +L LP +++ IKE+LR+ L+ K L Sbjct: 297 EVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLH 356 Query: 389 IPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYG 448 + + +Y + K + + P H + +P F R+ K + + + ++ Y Sbjct: 357 LEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYY 416 Query: 449 FGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFV--YNLRWTIDGYKVP--DPD 504 Y+PFG G C G FA ++ L + + L K P D Sbjct: 417 -----------YMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQS 465 Query: 505 YSSMVVLP 512 + + +LP Sbjct: 466 RAGLGILP 473 >6DWN-A nrPDB Length = 491 Score = 68.9 bits (167), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 74/289 (25%), Positives = 122/289 (42%), Gaps = 52/289 (17%) Query: 228 FTPINFVFPNLPLPHYWRRDAAQKKIS--ATYMKEIKSRRERGDIDPNRDLIDSLLIHST 285 F PI PN L + +D +K S +KE E+G I RD+ DSL+ H Sbjct: 209 FIPILRYLPNPSLNAF--KDLNEKFYSFMQKMVKEHYKTFEKGHI---RDITDSLIEHCQ 263 Query: 286 YKD-----GVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVEL 340 K V+++D++I N+++ + G T + +W L++L P +Q I +E+ + Sbjct: 264 EKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTV 323 Query: 341 LKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETN------- 393 + G D LP + I ET R HS F P IP + Sbjct: 324 I----GRSRRPRLSDRSHLPYMEAFILETFR-----HSSFV----PFTIPHSTTRDTSLK 370 Query: 394 -YIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKV 452 + +PKG V V+ + ++ + NP +F P R+ T G + Sbjct: 371 GFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPD------------------GAI 412 Query: 453 SKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTID-GYKV 500 K +S + FG G+ +CIGE A ++ L + + +++ G KV Sbjct: 413 DKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKV 461 >6B82-A nrPDB Length = 509 Score = 68.2 bits (165), Expect = 9e-12, Method: Compositional matrix adjust. Identities = 73/278 (26%), Positives = 113/278 (40%), Gaps = 65/278 (23%) Query: 273 NRDLIDSLLI--------HSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLG 324 RDL+D+LL +S+ +D V +T+ + + I G T+ +T W + +L Sbjct: 256 QRDLLDALLRAKRSSENNNSSTRD-VGLTEDHVLMTVGEIFGAGVETTTTTLKWSIAYLV 314 Query: 325 EKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVT 384 P +Q I +E L K G D LP + TI E +R+ + Sbjct: 315 HNPQVQRKIQEE----LDSKIGKERHPQLSDRGNLPYLEATICEVMRI---------RPV 361 Query: 385 NPLRIPET--------NYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANS 436 +PL IP Y V KG V+++ H E+ + NPE FDP R+ Sbjct: 362 SPLLIPHVALQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRF--------- 412 Query: 437 VSFNSSDEVDYGFGKVSKGVSSP---YLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRW 493 + G+ P YLPFG G C+GE A ++L L + R+ Sbjct: 413 ------------LNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQ--RF 458 Query: 494 TID---GYKVPDPDYSSMVVLPTEPAEII------WEK 522 T++ G +PD VVL + +++ WEK Sbjct: 459 TLEMPTGQPLPDLQGKFGVVLQPKKFKVVAKVRADWEK 496 Score = 31.2 bits (69), Expect = 1.0, Method: Compositional matrix adjust. Identities = 15/44 (34%), Positives = 25/44 (56%), Gaps = 2/44 (4%) Query: 46 DRAPLVFYWIPWFGSAASY--GQQPYEFFESCRQKYGDVFSFML 87 +R+P +P GS S P+ FF+ ++KYGD++S M+ Sbjct: 22 NRSPPSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDLYSLMM 65 >4R20-A nrPDB Length = 486 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 62/257 (24%), Positives = 104/257 (40%), Gaps = 46/257 (17%) Query: 234 VFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVK-- 291 +FPN L ++ + Y K ++ ++ +P RDL+D+LLI G Sbjct: 215 IFPNKDLKRL--KECVSIRDQLLYKKLLEHKKSLTPGEP-RDLLDALLIGQQRGSGGADD 271 Query: 292 MTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDL 351 +T+ + G T+++T W + L P LQ+ + E+ E + G Sbjct: 272 ITEDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECV----GVDRPP 327 Query: 352 TYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPET--------NYIVPKGHYVL 403 D LP ++ + E +R+ + +P+ IP + VPKG VL Sbjct: 328 CLSDRPHLPLLDAVLCEVMRI---------RPVSPILIPHVAMQDTSLGGHSVPKGTRVL 378 Query: 404 VSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPF 463 V+ H +++D PE F+P R+ + K K S +LPF Sbjct: 379 VNMWAIHHDPKHWDQPEQFNPERFLEPSGK--------------------KKTQSSFLPF 418 Query: 464 GGGRHRCIGEQFAYVQL 480 G G C+GE A ++L Sbjct: 419 GAGPRVCVGESLARIEL 435 >4R1Z-A nrPDB Length = 439 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 72/278 (25%), Positives = 113/278 (40%), Gaps = 65/278 (23%) Query: 273 NRDLIDSLLI--------HSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLG 324 RDL+D+LL +S+ +D V +T+ + + I G T+ + W + +L Sbjct: 192 QRDLLDALLRAKRSSENNNSSTRD-VGLTEDHVLMTVGDIFGAGVETTTTVLKWSIAYLV 250 Query: 325 EKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVT 384 P +Q I +E L K G D LP + TI+E LR+ + Sbjct: 251 HNPQVQRKIQEE----LDSKIGKERHPQLSDRGNLPYLEATIREVLRI---------RPV 297 Query: 385 NPLRIPET--------NYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANS 436 +PL IP Y V KG V+++ H ++ + NPE FDP R+ Sbjct: 298 SPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRF--------- 348 Query: 437 VSFNSSDEVDYGFGKVSKGVSSP---YLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRW 493 + G+ P YLPFG G C+GE A ++L L + R+ Sbjct: 349 ------------LNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQ--RF 394 Query: 494 TID---GYKVPDPDYSSMVVLPTEPAEII------WEK 522 T++ G +PD VVL + +++ WEK Sbjct: 395 TLEMPTGQPLPDLQGKFGVVLQPKKFKVVAKVRADWEK 432 >4GQS-A nrPDB Length = 477 Score = 66.2 bits (160), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 64/250 (25%), Positives = 114/250 (45%), Gaps = 32/250 (12%) Query: 253 ISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLI---GILMGGQ 309 + + ++++K +E DI+ RD ID LI + + ++ I NL+I +L G Sbjct: 223 MESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGT 282 Query: 310 HTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKET 369 T+++T + LL L + P + + +E+ ++ G +D +P + + E Sbjct: 283 ETTSTTLRYALLLLLKHPEVTAKVQEEIERVV----GRNRSPCMQDRGHMPYTDAVVHEV 338 Query: 370 LR-MHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWD 428 R + + S+ VT ++ NY++PKG +L S + F NPE FDP + Sbjct: 339 QRYIDLIPTSLPHAVTCDVKF--RNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHF- 395 Query: 429 TAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFV 488 +D G G K S+ ++PF G+ C+GE A ++L LT + Sbjct: 396 ----------------LDEG-GNFKK--SNYFMPFSAGKRICVGEGLARMELFLFLTFIL 436 Query: 489 --YNLRWTID 496 +NL+ ID Sbjct: 437 QNFNLKSLID 446 >3IBD-A nrPDB Length = 476 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 108/460 (23%), Positives = 179/460 (38%), Gaps = 97/460 (21%) Query: 72 FESCRQKYGDVFSFMLLGKIMTVYLGPK------GHEFVFNAKLSDVSAEDAYKHLTT-- 123 F R+KYGDVF TV+LGP+ G E + A + A + Sbjct: 36 FLRFREKYGDVF---------TVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVD 86 Query: 124 PVF-GKGVIYDCPNSRLMEQKKFAKFALTT----DSFKRYVP-KIREEILNYF------- 170 P F G GVI+ N K +F++TT KR V +I+EE Sbjct: 87 PFFRGYGVIFANGN----RWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSK 142 Query: 171 --VTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDE----MRRIFDRSFAQLYSDL 224 + D +F + T AN++ +I R + D+ M +F ++F+ + S Sbjct: 143 GALMDPTFLFQSIT---ANII-----CSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVF 194 Query: 225 DKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHS 284 + F + + P H Q+ I+A ++ RE D RDLID+ L+H Sbjct: 195 GQLFELFSGFLKHFPGAHRQVYKNLQE-INAYIGHSVEKHRETLDPSAPRDLIDTYLLHM 253 Query: 285 TYKDGVKMTDQEIANL---LIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELL 341 + ++ NL + + G T+++T + L + + PH+ + +Y+E+ +++ Sbjct: 254 EKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVI 313 Query: 342 KEKGGDLNDLTYEDLQKLPSVNNTIKETLRMH--MPL--------HSIFRKVTNPLRIPE 391 G D K+P I E R +P+ H+ FR Sbjct: 314 ----GPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFR---------- 359 Query: 392 TNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGK 451 YI+PK V + A YF+ P+ F+P + A G Sbjct: 360 -GYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDAN------------------GA 400 Query: 452 VSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL 491 + K + ++PF G+ C+GE A +L TT + N Sbjct: 401 LKK--TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNF 438 >2HI4-A nrPDB Length = 495 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 105/483 (21%), Positives = 184/483 (38%), Gaps = 80/483 (16%) Query: 56 PWFGSAASYGQQPYEFFESCRQKYGDVFSF-------MLLGKIMTV--YLGPKGHEF--- 103 P G + G+ P+ Q+YGDV ++L ++ T+ L +G +F Sbjct: 25 PLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGR 84 Query: 104 --VFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPK 161 ++ + L + + PV+ R + Q F++ +D Sbjct: 85 PDLYTSTLITDGQSLTFSTDSGPVWAA--------RRRLAQNALNTFSIASDPASSSSCY 136 Query: 162 IREEILNYFVTDESFKLKEKTHG-------------VANVMKTQPEITIFTASRSLFGDE 208 + E + S +L+E G VANV+ F S DE Sbjct: 137 LEEHVSKEAKALIS-RLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPES----SDE 191 Query: 209 MRRIFDRSFAQLYSDLDKGFTPINF--VFPNLPLPHYWRRDAAQKKISATYMKEIKSRRE 266 M + + + + P++F + LP P R A ++ K ++ + Sbjct: 192 MLSLVKNTHE--FVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQ 249 Query: 267 RGDIDPNRDLIDSLLIHST---YKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHL 323 D + RD+ +L HS G + ++I NL+ I G T + +W L++L Sbjct: 250 DFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYL 309 Query: 324 GEKPHLQDVIYQEVVELL-KEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRK 382 KP +Q I +E+ ++ +E+ L+D +LP + I ET R HS F Sbjct: 310 VTKPEIQRKIQKELDTVIGRERRPRLSDRP-----QLPYLEAFILETFR-----HSSFLP 359 Query: 383 VTNPLRIPE----TNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVS 438 T P + +PK V V+ + +++P +F P R+ TA A Sbjct: 360 FTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTA---- 415 Query: 439 FNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTI-DG 497 ++K +S + FG G+ RCIGE A ++ L + L +++ G Sbjct: 416 -------------INKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG 462 Query: 498 YKV 500 KV Sbjct: 463 VKV 465 >1N6B-A nrPDB Length = 473 Score = 65.9 bits (159), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 54/236 (22%), Positives = 106/236 (44%), Gaps = 27/236 (11%) Query: 258 MKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSA 317 M+++K ++ D++ RD ID LI ++ ++ T + + + + G T+++T Sbjct: 227 MEKVKEHQKLLDVNNPRDFIDCFLIKMEQENNLEFTLESLVIAVSDLFGAGTETTSTTLR 286 Query: 318 WFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLR-MHMPL 376 + LL L + P + + +E+ ++ G +D ++P + I E R + + Sbjct: 287 YSLLLLLKHPEVAARVQEEIERVI----GRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLP 342 Query: 377 HSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANS 436 ++ VT +R NY +PKG ++ S E+ F NP+ FDP + + Sbjct: 343 TNLPHAVTRDVRF--RNYFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESG---- 396 Query: 437 VSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLR 492 +F SD ++PF G+ C+GE A ++L LT+ + N + Sbjct: 397 -NFKKSDY---------------FMPFSAGKRMCVGEGLARMELFLFLTSILQNFK 436 >5W0C-A nrPDB Length = 477 Score = 62.4 bits (150), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 57/245 (23%), Positives = 110/245 (44%), Gaps = 32/245 (13%) Query: 258 MKEIKSRRERGDIDPNRDLIDSLLIH---STYKDGVKMTDQEIANLLIGILMGGQHTSAS 314 ++++K +E D++ +D ID L+ + + T + + N + + G T+++ Sbjct: 228 LEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTST 287 Query: 315 TSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLR-MH 373 T + LL L + P + + +E+ ++ G +D +P + + E R + Sbjct: 288 TLRYALLLLLKHPEVTAKVQEEIERVI----GRNRSPCMQDRSHMPYTDAVVHEVQRYID 343 Query: 374 MPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAK 433 + S+ VT ++ NY++PKG +L+S + F NPE FDP + Sbjct: 344 LLPTSLPHAVTCDIKF--RNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHF------ 395 Query: 434 ANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFV--YNL 491 +D G G K S ++PF G+ C+GE A ++L LT+ + +NL Sbjct: 396 -----------LDEG-GNFKK--SKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 441 Query: 492 RWTID 496 + +D Sbjct: 442 KSLVD 446 >6DA2-A nrPDB Length = 487 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 67/280 (23%), Positives = 114/280 (40%), Gaps = 40/280 (14%) Query: 224 LDKGFTPINFVFPNL-PLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLID--SL 280 LD F I VFP L P+ ++++ K +K +E D + +D L Sbjct: 196 LDPFFLSIT-VFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQL 254 Query: 281 LIHSTYKDGVK----MTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQE 336 +I S + ++D E+ I + G T++S ++ + L P +Q + +E Sbjct: 255 MIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEE 314 Query: 337 VVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIV 396 + +L K TY+ + ++ ++ + ETLR+ + R + I + Sbjct: 315 IDAVLPNKAPP----TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI--NGMFI 368 Query: 397 PKGHYVLVSPGYA-HTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKG 455 PKG V++ P YA H +Y+ PE F P R F K +K Sbjct: 369 PKGVVVMI-PSYALHRDPKYWTEPEKFLPER----------------------FSKKNKD 405 Query: 456 VSSPYL--PFGGGRHRCIGEQFAYVQLGTILTTFVYNLRW 493 PY+ PFG G CIG +FA + + L + N + Sbjct: 406 NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSF 445 >5VEU-A nrPDB Length = 480 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 51/205 (24%), Positives = 88/205 (42%), Gaps = 33/205 (16%) Query: 292 MTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDL 351 ++D E+A I + G T++S ++ L L P +Q + +E+ +L K Sbjct: 269 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPP---- 324 Query: 352 TYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYA-H 410 TY+ + ++ ++ + ETLR+ + R + I +PKG V++ P YA H Sbjct: 325 TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI--NGVFIPKGSMVVI-PTYALH 381 Query: 411 TSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYL--PFGGGRH 468 +Y+ PE+F P R+ D +D PY+ PFG G Sbjct: 382 HDPKYWTEPEEFRPERFS-----------KKKDSID------------PYIYTPFGTGPR 418 Query: 469 RCIGEQFAYVQLGTILTTFVYNLRW 493 CIG +FA + + L + N + Sbjct: 419 NCIGMRFALMNMKLALIRVLQNFSF 443 >5E0E-A nrPDB Length = 463 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 59/237 (24%), Positives = 102/237 (43%), Gaps = 34/237 (14%) Query: 265 RERGDIDPN--RDLIDSLLIHSTYKDGVKMTDQEIANLLIGIL---MGGQHTSASTSAWF 319 + R +DP+ RD ID+ L+ + + T+ + NL+I +L G TS++T + Sbjct: 223 KHRATLDPSHPRDFIDTYLLRMEKEKSNQHTEFDHQNLVISVLSLFFAGTETSSTTLRYG 282 Query: 320 LLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMH--MPLH 377 L + + PH+ + + +E+ +++ G T ED K+P I E R +P+ Sbjct: 283 FLLMLKYPHVAEKVQKEIDQVI----GSHRLPTLEDRTKMPYTEAVIYEIQRFSDLIPI- 337 Query: 378 SIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSV 437 + KVT Y++PK V A +YF+ P+ F+P + A Sbjct: 338 GVPHKVTKDTLF--RGYLLPKNTEVYPILSSALHDPQYFEQPDTFNPDHFLDAN------ 389 Query: 438 SFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWT 494 G + K S ++PF G+ C+GE A +L TT + N + Sbjct: 390 ------------GALKK--SEAFMPFSIGKRICLGEGIARNELFLFFTTILQNFSLS 432 >5E58-A nrPDB Length = 493 Score = 58.5 bits (140), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 57/236 (24%), Positives = 99/236 (41%), Gaps = 38/236 (16%) Query: 265 RERGDIDPN--RDLIDSLLIHSTYKDGVKMTDQEIANLLIGIL---MGGQHTSASTSAWF 319 + R +DP+ RD ID+ L+ + + T+ NLLI +L G T+++T + Sbjct: 251 KHRATLDPSNPRDFIDTYLLRMEKEKSNQHTEFHHQNLLISVLSLFFAGTETTSTTLRYG 310 Query: 320 LLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSI 379 L + + PH+ + + +E+ +++ G T ED K+P + I E R S Sbjct: 311 FLLMLKYPHVAEKVQKEIDQVI----GSHRLPTLEDRTKMPYTDAVIHEIQRF-----SD 361 Query: 380 FRKVTNPLRIPE----TNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKAN 435 + P ++ + Y++PK V A +YF+ P F+P + A Sbjct: 362 LAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSALHDPQYFEQPGTFNPDHFLDAN---- 417 Query: 436 SVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL 491 G + K S ++PF G+ C+GE A +L TT + N Sbjct: 418 --------------GALKK--SEAFMPFSIGKRICLGEGIARNELFLFFTTILQNF 457 >5UYS-A nrPDB Length = 494 Score = 58.5 bits (140), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 71/303 (23%), Positives = 113/303 (37%), Gaps = 66/303 (21%) Query: 234 VFPNLPL----PHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDG 289 +FPN L H R+ KI Y ++ +S D +++D+L+ D Sbjct: 205 IFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRS-------DSITNMLDTLMQAKMNSDN 257 Query: 290 VK---------MTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVEL 340 ++D I + I G T+ S W L L P ++ +Y+E+ Sbjct: 258 GNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEI--- 314 Query: 341 LKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPET-------- 392 + G T D +L + TI+E LR+ + P+ IP Sbjct: 315 -DQNVGFSRTPTISDRNRLLLLEATIREVLRL---------RPVAPMLIPHKANVDSSIG 364 Query: 393 NYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKV 452 + V KG V+++ H +E+ + P+ F P R+ A G + Sbjct: 365 EFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPA----------------GTQLI 408 Query: 453 SKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLP 512 S VS YLPFG G CIGE A +L I+ W + + + PD + L Sbjct: 409 SPSVS--YLPFGAGPRSCIGEILARQELFLIMA-------WLLQRFDLEVPDDGQLPSLE 459 Query: 513 TEP 515 P Sbjct: 460 GIP 462 >3DL9-A nrPDB Length = 479 Score = 58.5 bits (140), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 50/222 (22%), Positives = 91/222 (40%), Gaps = 29/222 (13%) Query: 304 ILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVN 363 +++ G T+ + W +L + P++Q + +E+ ++ G +++D K+P Sbjct: 281 LIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKP----SWDDKCKMPYTE 336 Query: 364 NTIKETLRMH--MPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPED 421 + E LR +PL IF + + Y +PKG V+ + H E+Y+ +PE Sbjct: 337 AVLHEVLRFCNIVPL-GIFHATSEDAVV--RGYSIPKGTTVITNLYSVHFDEKYWRDPEV 393 Query: 422 FDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLG 481 F P R+ +S + + E +PF GR C+GE A +++ Sbjct: 394 FHPERF------LDSSGYFAKKEA--------------LVPFSLGRRHCLGEHLARMEMF 433 Query: 482 TILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIWEKR 523 T + VPD + L +P I E+R Sbjct: 434 LFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR 475 >3NC3-A nrPDB Length = 441 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 57/244 (23%), Positives = 96/244 (39%), Gaps = 49/244 (20%) Query: 249 AQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGG 308 +++S M IK RR ++P DLI S+L S Y +G+ ++D++I L++ +L+ Sbjct: 217 CSEQLSQYLMPVIKERR----VNPGSDLI-SILCTSEY-EGMALSDKDILALILNVLLAA 270 Query: 309 QHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKE 368 + T A + HL P +ND+ L V I E Sbjct: 271 TEPADKTLALMIYHLLNNPE------------------QMNDV----LADRSLVPRAIAE 308 Query: 369 TLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWD 428 TLR P+ I R+++ + + K V G A+ F+ P+ F+ R D Sbjct: 309 TLRYKPPVQLIPRQLSQDTVVGGME--IKKDTIVFCMIGAANRDPEAFEQPDVFNIHRED 366 Query: 429 TAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFV 488 A F ++ +L FG G H C+G FA ++ + + Sbjct: 367 LGIKSA--------------FSGAAR-----HLAFGSGIHNCVGTAFAKNEIEIVANIVL 407 Query: 489 YNLR 492 +R Sbjct: 408 DKMR 411 >2NNH-A nrPDB Length = 476 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 66/301 (21%), Positives = 122/301 (40%), Gaps = 41/301 (13%) Query: 214 DRSFAQLYSDLDKGFTPINF----VFPNLPL-----PHYWRRDAAQKKISATYMKE-IKS 263 D++F L ++ F +N V N PL P + ++ +Y++E +K Sbjct: 173 DQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKE 232 Query: 264 RRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLL---IGILMGGQHTSASTSAWFL 320 + D++ RD ID LI + + ++ I NL+ + + G T+++T + L Sbjct: 233 HQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGL 292 Query: 321 LHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMH-MPLHSI 379 L L + P + + +E+ ++ G +D +P + + E R + + Sbjct: 293 LLLLKHPEVTAKVQEEIDHVI----GRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGV 348 Query: 380 FRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSF 439 VT + NY++PKG ++ ++ F NP FDP + +F Sbjct: 349 PHAVTTDTKF--RNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNG-----NF 401 Query: 440 NSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRW-TIDGY 498 SD ++PF G+ C GE A ++L LTT + N ++D Sbjct: 402 KKSDY---------------FMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDL 446 Query: 499 K 499 K Sbjct: 447 K 447 >4H1N-A nrPDB Length = 479 Score = 54.7 bits (130), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 54/239 (22%), Positives = 96/239 (40%), Gaps = 46/239 (19%) Query: 265 RERGDIDPN--RDLIDSLLIHSTYKDGVKMTDQEIANLLIGIL---MGGQHTSASTSAWF 319 + R +DP+ RD ID L+ ++ NL++ +L G T+++T + Sbjct: 232 KHRATLDPSNPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYG 291 Query: 320 LLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSI 379 L + + PH+ + + +E+ +++ G +D K+P + I E R+ + Sbjct: 292 FLLMLKYPHVTERVQKEIEQVI----GSHRPPALDDRAKMPYTDAVIHEIQRLGDLI--- 344 Query: 380 FRKVTNPLRIPET--------NYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAA 431 P +P T Y++PK V A RYF+ P F+P + A Sbjct: 345 ------PFGVPHTVTKDTQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDA- 397 Query: 432 AKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYN 490 N + + + GF +PF G+ C+GE A +L TT + N Sbjct: 398 --------NGALKRNEGF-----------MPFSLGKRICLGEGIARTELFLFFTTILQN 437 >3B98-A nrPDB Length = 475 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 109/461 (23%), Positives = 176/461 (38%), Gaps = 60/461 (13%) Query: 44 RKDRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEF 103 R++ PL IPW G A +G+ +F ++K+GD+F+ G +TV L Sbjct: 16 RRNEPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYITVLLDSN---- 71 Query: 104 VFNAKLSDVSAEDAYKH---LTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVP 160 ++A LSDV++ D + L +F + P S +KK A+ S + Sbjct: 72 CYDAVLSDVASLDQTSYAQVLMKRIFNMILPSHNPES----EKKRAEMHFQGASLTQLSN 127 Query: 161 KIREEILNYFVTDESFKLKE---KTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSF 217 ++ L +T LK K G+ N+ + + T ++FG E + Sbjct: 128 SMQNN-LRLLMTPSEMGLKTSEWKKDGLFNLCYS---LLFKTGYLTVFGAENNN--SAAL 181 Query: 218 AQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKI-SATYMKEIKSRRERG-DIDPNRD 275 Q+Y + F + + P L + +K+I SA K K G D P Sbjct: 182 TQIYEE----FRRFDKLLPKLARTTV---NKEEKQIASAAREKLWKWLTPSGLDRKPREQ 234 Query: 276 LIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQ 335 + +G+ Q A LL L Q + + W + +L P + + Sbjct: 235 SWLGSYVKQLQDEGIDAEMQRRAMLL--QLWVTQGNAGPAAFWVMGYLLTHPEALRAVRE 292 Query: 336 EVVELLKEKGGDLNDLTYEDLQK-LPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETN- 393 E+ +GG L E+ QK P ++ + ETLR+ I R VT +I +N Sbjct: 293 EI------QGG--KHLRLEERQKNTPVFDSVLWETLRL-TAAALITRDVTQDKKICLSNG 343 Query: 394 --YIVPKGHYVLVSPGYA-HTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFG 450 Y + +G + V P + + PE F R+ A F + V Y Sbjct: 344 QEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKKDFFKNGARVKY--- 400 Query: 451 KVSKGVSSPYLPFGGGRHRCIGEQFAYVQLG----TILTTF 487 P +P+G + C G FA + TILT F Sbjct: 401 --------PSVPWGTEDNLCPGRHFAVHAIKELVFTILTRF 433 >5Z9I-A nrPDB Length = 398 Score = 53.1 bits (126), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 51/208 (24%), Positives = 85/208 (40%), Gaps = 55/208 (26%) Query: 272 PNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQD 331 P DLI S L+H+ DG K+ D +I+N+ +L+ G T+A A +L L Sbjct: 204 PREDLI-SQLVHAEV-DGQKLNDSQISNIANRLLVNGHLTTAMLIANTMLCL-------- 253 Query: 332 VIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPE 391 + D + D +P++ ++E++R P+ + R + + + Sbjct: 254 -----------DAFSDQDARVRADRSLVPAL---LEESMRYMSPICGVGRATNSEVEVAG 299 Query: 392 TNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGK 451 T ++PK +LV G A+ ER F+ P+ FD R A Sbjct: 300 T--VIPKDQLLLVWTGAANRDERQFEKPDVFDAGRSPNA--------------------- 336 Query: 452 VSKGVSSPYLPFGGGRHRCIGEQFAYVQ 479 +L FG G H C+G Q A ++ Sbjct: 337 --------HLGFGRGIHFCLGRQLARME 356 >3S79-A nrPDB Length = 503 Score = 51.6 bits (122), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 44/197 (22%), Positives = 85/197 (43%), Gaps = 32/197 (16%) Query: 292 MTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDL 351 +T + + ++ +L+ T + + + L + + P++++ I +E+ ++ E+ D+ Sbjct: 291 LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGER-----DI 345 Query: 352 TYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHT 411 +D+QKL + N I E++R + + RK I Y V KG ++++ G H Sbjct: 346 KIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVI--DGYPVKKGTNIILNIGRMHR 403 Query: 412 SERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCI 471 E +F P +F N + V Y + + PFG G C Sbjct: 404 LE-FFPKPNEFTLE--------------NFAKNVPYRY----------FQPFGFGPRGCA 438 Query: 472 GEQFAYVQLGTILTTFV 488 G+ A V + IL T + Sbjct: 439 GKYIAMVMMKAILVTLL 455 >3E6I-A nrPDB Length = 476 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 107/476 (22%), Positives = 191/476 (40%), Gaps = 118/476 (24%) Query: 72 FESCRQKYGDVFSFMLLGKIMTVYLGPKG-HEFVFNAK-----LSDVSAEDAYKHLTTPV 125 F Q++G VF+ + + M V G K E + + K D+ A A++ Sbjct: 36 FTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHR------ 89 Query: 126 FGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVT---DESFKLKEKT 182 +G+I++ + K +F+LTT + NY + +ES +E Sbjct: 90 -DRGIIFNNGPT----WKDIRRFSLTT-------------LRNYGMGKQGNESRIQREAH 131 Query: 183 HGVANVMKTQ-----PEITIFTASRSLFGDEM-RRIFD---RSFAQLYSDLDKGF----T 229 + + KTQ P I A ++ D + R+ FD F +L ++ F T Sbjct: 132 FLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLST 191 Query: 230 PINFVFPNLP-----LPHYWRRDAAQKKISATYMKEIKSRRERGDIDPN--RDLIDSLLI 282 P ++ N P LP R+ Y+ E + + +DPN RDL D LL+ Sbjct: 192 PWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSE-RVKEHHQSLDPNCPRDLTDCLLV 250 Query: 283 ------HSTYK----DGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDV 332 HS + DG+ +T +A+L G T+++T + LL L + P +++ Sbjct: 251 EMEKEKHSAERLYTMDGITVT---VADLF----FAGTETTSTTLRYGLLILMKYPEIEEK 303 Query: 333 IYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRM------HMPLHS----IFRK 382 +++E+ ++ G +D Q++P ++ + E R ++P + IFR Sbjct: 304 LHEEIDRVI----GPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFR- 358 Query: 383 VTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSS 442 Y++PKG V+ + + F +PE F P + N + Sbjct: 359 ----------GYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHF-----------LNEN 397 Query: 443 DEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFV--YNLRWTID 496 + Y S + PF G+ C GE A ++L +L + +NL+ +D Sbjct: 398 GKFKY---------SDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVD 444 >6IQ5-A nrPDB Length = 463 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 51/228 (22%), Positives = 91/228 (39%), Gaps = 38/228 (16%) Query: 274 RDLIDSLLIHS-------TYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEK 326 RD++D+ ++ + ++ G ++ + + + I Q T ++ W LL Sbjct: 223 RDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRY 282 Query: 327 PHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNP 386 P +Q + E+ +++ G D LP V + E +R S F VT P Sbjct: 283 PDVQTRVQAELDQVV----GRDRLPCMGDQPNLPYVLAFLYEAMRF-----SSFVPVTIP 333 Query: 387 LRIPETN----YIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSS 442 Y +PK V V+ + + NPE+FDP R F Sbjct: 334 HATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNPENFDPAR------------FLDK 381 Query: 443 DEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYN 490 D G ++K ++S + F G+ RCIGE+ + +QL ++ + Sbjct: 382 D------GLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQ 423 >4KPA-A nrPDB Length = 494 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 55/238 (23%), Positives = 99/238 (41%), Gaps = 39/238 (16%) Query: 259 KEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAW 318 K I R+ G+ + DL+ +L + G + D+ I +I L+ G T++ ++ Sbjct: 242 KIIADRKASGE--QSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSF 299 Query: 319 FLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRM--HMPL 376 L L + PH+ +E +L + +Y+ +++L V + E LR+ P Sbjct: 300 ALYFLVKNPHVLQKAAEEAARVLVDPVP-----SYKQVKQLKYVGMVLNEALRLWPTAPA 354 Query: 377 HSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYF-DNPEDFDPTRWDTAAAKAN 435 S++ K L Y + KG ++V H + + D+ E+F P R++ +A Sbjct: 355 FSLYAKEDTVLG---GEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQ 411 Query: 436 SVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQ----LGTILTTFVY 489 + PFG G+ CIG+QFA + LG +L F + Sbjct: 412 HA----------------------FKPFGNGQRACIGQQFALHEATLVLGMMLKHFDF 447 >3TBG-A nrPDB Length = 479 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 98/478 (20%), Positives = 174/478 (36%), Gaps = 65/478 (13%) Query: 64 YGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTT 123 + PY F+ R+++GDVFS L + V G V A ++ ED Sbjct: 29 FQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVL---NGLAAVREALVT--HGEDTADRPPV 82 Query: 124 PV-----FG---KGVIYDCPNSRLMEQKKFA-----KFALTTDSFKRYVPKIREEILNYF 170 P+ FG +GV EQ++F+ L S +++V + + F Sbjct: 83 PITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAF 142 Query: 171 VTDESFKLKEK---THGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKG 227 + V+NV I T R D+ R + AQ + G Sbjct: 143 ANHSGRPFRPNGLLDKAVSNV------IASLTCGRRFEYDDPRFLRLLDLAQEGLKEESG 196 Query: 228 FTP--INFVFPNLPLPHYWRRDAAQKKISATYMKEI--KSRRERGDIDPNRDLIDSLLIH 283 F +N V L +P + +K T + E+ + R P RDL ++ L Sbjct: 197 FLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAE 256 Query: 284 STYKDG---VKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVEL 340 G D+ + ++ + G T+++T AW LL + P +Q + QE+ ++ Sbjct: 257 MEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDV 316 Query: 341 LKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMH--MPLHSIFRKVTNPLRIPETNYIVPK 398 + G + D +P I E R +PL + + + + + +PK Sbjct: 317 I----GQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPL-GVTHMTSRDIEV--QGFRIPK 369 Query: 399 GHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSS 458 G ++ + E ++ P F P + A G K Sbjct: 370 GTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQ------------------GHFVK--PE 409 Query: 459 PYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPA 516 +LPF GR C+GE A ++L T+ + + +++ + P P + + P+ Sbjct: 410 AFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQ-PRPSHHGVFAFLVSPS 466 >5FYF-A nrPDB Length = 470 Score = 48.9 bits (115), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 53/235 (22%), Positives = 88/235 (37%), Gaps = 55/235 (23%) Query: 247 DAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILM 306 DAA S + + K R +P DLI L + KD + + I NL + +++ Sbjct: 248 DAADMARSFSRLWRDKEARRAAGEEPGFDLISLLQSNKETKDLINRPMEFIGNLTL-LIV 306 Query: 307 GGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPS-VNNT 365 GG T+ ++ + L+ + E P +E L+ P + N Sbjct: 307 GGNDTTRNSMSGGLVAMNEFPR-----------------------EFEKLKAKPELIPNM 343 Query: 366 IKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPT 425 + E +R PL + R + + + KG V++ + ER FDNP+ F Sbjct: 344 VSEIIRWQTPLAYMRRIAKQDVEL--GGQTIKKGDRVVMWYASGNRDERKFDNPDQFIID 401 Query: 426 RWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQL 480 R D + ++ FG G HRC+G + A +QL Sbjct: 402 RKD----------------------------ARNHMSFGYGVHRCMGNRLAELQL 428 >4WPZ-A nrPDB Length = 397 Score = 48.9 bits (115), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 59/243 (24%), Positives = 95/243 (39%), Gaps = 71/243 (29%) Query: 246 RDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDG-VKMTDQEIANLLIGI 304 ++AA + + + I +RE +P DLI L+ S DG +T++EI L IGI Sbjct: 177 KEAATVSLVNYFGELIAVKRE----NPADDLISELIAIS---DGDSTLTEREIIALSIGI 229 Query: 305 LMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKL----P 360 L G T+A+ + FL+ L P E+L KL Sbjct: 230 LSAGHETTANQISMFLVTLLHNP--------------------------EELDKLRDNRE 263 Query: 361 SVNNTIKETLRMHMPLHS---IFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFD 417 ++ + E LR +PL + I ++T ++P G VL + A+ F+ Sbjct: 264 AIPKAVDELLRF-VPLTTTGGIIPRLTTAEVELSGGQVLPAGAVVLPAVATANRDPEVFE 322 Query: 418 NPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAY 477 + E + TR + +P+L FG G H C+G Q A Sbjct: 323 DGERLNVTREN-----------------------------NPHLAFGAGIHHCLGAQLAR 353 Query: 478 VQL 480 ++L Sbjct: 354 IEL 356 >4GGV-A nrPDB Length = 418 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 54/235 (22%), Positives = 90/235 (38%), Gaps = 59/235 (25%) Query: 246 RDAAQK-KISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGI 304 RDA ++ + YM + R R P DL+ L+ DG ++TD EI N+ + Sbjct: 200 RDATERLRPLLDYMAGHVTERRRT---PREDLLTHLV--QAEVDGERLTDNEIVNVANIL 254 Query: 305 LMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNN 364 L+ G T+ T +L L P + + + + L V Sbjct: 255 LVTGHITTTMTLGNTVLCLDADPEVAAKVRAD--------------------RSL--VPG 292 Query: 365 TIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDP 424 I+E LR+ P ++ R + + + T ++PK V++ G + R F +PE +DP Sbjct: 293 AIEEALRVLSPSAALARGTSREVEVAGT--VIPKDQIVMLWLGAGNRDPRQFTDPEVYDP 350 Query: 425 TRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQ 479 TR +P+ FG G H C+G A ++ Sbjct: 351 TR-----------------------------DPNPHFGFGRGIHFCLGAPLARLE 376 >5L94-A nrPDB Length = 410 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 55/240 (22%), Positives = 92/240 (38%), Gaps = 59/240 (24%) Query: 249 AQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGG 308 A ++ + + I+ +R R P D+I LL ++G ++TD+EI I +L+ G Sbjct: 190 ANDELETYFYRIIEEKRTR----PGDDIISVLL--QAKEEGKQLTDEEIVGFSILLLIAG 243 Query: 309 QHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKE 368 T+ + + + IY L E L E + LPS I+E Sbjct: 244 NETTTNL-------------ISNTIY-----CLMEDKASFERLKREK-ELLPS---GIEE 281 Query: 369 TLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWD 428 LR P+ ++ R V + + + G +V+ G AH YF++PE F R Sbjct: 282 VLRYRSPVQALHRIVKEDVTL--AGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFKIDR-- 337 Query: 429 TAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFV 488 K N ++ FG G H C+G A ++ +L + Sbjct: 338 ----KPNV-----------------------HMAFGRGIHFCLGAPLARIEAKIMLAELI 370 >2VZM-A nrPDB Length = 436 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 63/289 (21%), Positives = 108/289 (37%), Gaps = 78/289 (26%) Query: 233 FVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKM 292 FVFP+ P + A ++S + I S+R + DL+ S L+ ++ +DG ++ Sbjct: 198 FVFPDDPA----QAQTAMAEMSGYLSRLIDSKRGQD----GEDLL-SALVRTSDEDGSRL 248 Query: 293 TDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLT 352 T +E+ + +L+ G T+ + A + L P + ++ L Sbjct: 249 TSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLL------------ 296 Query: 353 YEDLQKLPSVNNTIKETLRMHMPLHS-IFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHT 411 + ++E LR P+ S +R P+ + T ++P G VLV AH Sbjct: 297 ----------DGAVEEMLRYEGPVESATYRFPVEPVDLDGT--VIPAGDTVLVVLADAHR 344 Query: 412 SERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCI 471 + F +P FD R DTA +L FG G H CI Sbjct: 345 TPERFPDPHRFD-IRRDTAG----------------------------HLAFGHGIHFCI 375 Query: 472 GEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIW 520 G A ++ + + + PD + L P E++W Sbjct: 376 GAPLARLEARIAVRALL---------ERCPD------LALDVSPGELVW 409 >2IAG-A nrPDB Length = 482 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 20/61 (32%), Positives = 33/61 (54%) Query: 44 RKDRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEF 103 R PL IPW G A +G+ F ++K+GD+F+ ++ G+ +TV L P ++ Sbjct: 4 RPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDA 63 Query: 104 V 104 V Sbjct: 64 V 64 Score = 28.1 bits (61), Expect = 9.9, Method: Compositional matrix adjust. Identities = 44/208 (21%), Positives = 92/208 (44%), Gaps = 24/208 (11%) Query: 277 IDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQE 336 ++S L+H + + ++++ A L+ L Q + W LL L + P + E Sbjct: 234 LESYLLH---LEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGE 290 Query: 337 VVELL---KEKGGDLNDLTYEDLQKLPSVNNTIKETLRM-HMPLHSIFRKVTNPLRIPET 392 + +L ++ L + L P +++ + E+LR+ P I R+V L +P Sbjct: 291 LESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPF--ITREVVVDLAMPMA 348 Query: 393 N---YIVPKGHYVLVSPGYA-HTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYG 448 + + + +G +L+ P + + +PE F R+ ++ + S++ D Sbjct: 349 DGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRF---------LNPDGSEKKD-- 397 Query: 449 FGKVSKGVSSPYLPFGGGRHRCIGEQFA 476 F K K + + +P+G G + C+G +A Sbjct: 398 FYKDGKRLKNYNMPWGAGHNHCLGRSYA 425 >2WIO-A nrPDB Length = 431 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 54/237 (22%), Positives = 84/237 (35%), Gaps = 54/237 (22%) Query: 261 IKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFL 320 +K+R DP DLI L++ DG + D+E AN +L+ G T+ Sbjct: 217 LKARCAERRADPGDDLISRLVLAEV--DGRALDDEEAANFSTALLLAGHITTT------- 267 Query: 321 LHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIF 380 V+ +V L E D ED ++P++ ++E LR P + Sbjct: 268 -----------VLLGNIVRTLDEHPAHW-DAAAEDPGRIPAI---VEEVLRYRPPFPQMQ 312 Query: 381 RKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFN 440 R T + +P V A+ D+P+ FDP+R AA+ Sbjct: 313 RTTTKATEV--AGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSRKSGGAAQ------- 363 Query: 441 SSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL-RWTID 496 L FG G H C+G A ++ L + R T+D Sbjct: 364 --------------------LSFGHGVHFCLGAPLARLENRVALEEIIARFGRLTVD 400 >2XKR-A nrPDB Length = 398 Score = 45.4 bits (106), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 70/259 (27%), Positives = 102/259 (39%), Gaps = 67/259 (25%) Query: 261 IKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFL 320 I +RR DP DL+ L+ S+ DG +++D E+ + IL+GG T+ T Sbjct: 190 IAARR----ADPTDDLVSVLV--SSEVDGERLSDDELVMETLLILIGGDETTRHT----- 238 Query: 321 LHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIF 380 L G + +LL+ + D DL D LP I+E LR P+ ++ Sbjct: 239 LSGGTE------------QLLRNR--DQWDLLQRDPSLLPGA---IEEMLRWTAPVKNMC 281 Query: 381 RKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFN 440 R +T T G +++ A+ E F PE FD R NS Sbjct: 282 RVLTADTEFHGTALCA--GEKMMLLFESANFDEAVFCEPEKFDVQR------NPNS---- 329 Query: 441 SSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKV 500 +L FG G H C+G Q A ++L +++T V LR D V Sbjct: 330 -------------------HLAFGFGTHFCLGNQLARLEL-SLMTERV--LRRLPDLRLV 367 Query: 501 PDPDYSSMVVLPTEPAEII 519 D VLP PA + Sbjct: 368 ADDS-----VLPLRPANFV 381 >1WIY-A nrPDB Length = 389 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 44/191 (23%), Positives = 68/191 (35%), Gaps = 48/191 (25%) Query: 302 IGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPS 361 + +L+ G T AS W L L +P Q + + + Sbjct: 216 VTLLVAGHETVASALTWSFLLLSHRPDWQKRVAESEE----------------------A 253 Query: 362 VNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPED 421 +E LR++ P + R++ PL + E +P+G +++SP Y T YF E Sbjct: 254 ALAAFQEALRLYPPAWILTRRLERPLLLGEDR--LPQGTTLVLSP-YV-TQRLYFPEGEA 309 Query: 422 FDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLG 481 F P R F S Y PFG G+ C+G FA ++ Sbjct: 310 FQPER----------------------FLAERGTPSGRYFPFGLGQRLCLGRDFALLEGP 347 Query: 482 TILTTFVYNLR 492 +L F R Sbjct: 348 IVLRAFFRRFR 358 >5OFQ-A nrPDB Length = 409 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 50/223 (22%), Positives = 91/223 (40%), Gaps = 58/223 (26%) Query: 257 YMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTS 316 Y KEI + R++ + DLI SLL+ + DG +T++E+ I +L+ G T+ + Sbjct: 196 YFKEIIAERQQ---NKQEDLI-SLLLEAEI-DGEHLTEEEVLGFCILLLVAGNETTTN-- 248 Query: 317 AWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPL 376 L+ G + +DV D+ + D+ +P N ++ETLR + P+ Sbjct: 249 ---LITNGVRYMTEDV--------------DVQNEVRRDISLVP---NLVEETLRYYPPI 288 Query: 377 HSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANS 436 +I R + + E + +G V+ A+ F+ P+ F Sbjct: 289 QAIGRIAAEDVELGECK--IKRGQQVISWAASANRDSAKFEWPDTF-------------- 332 Query: 437 VSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQ 479 V ++P++ FG G H C+G A ++ Sbjct: 333 ---------------VVHRKTNPHVSFGFGIHFCLGAPLARME 360 >1CPT-A nrPDB Length = 428 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 47/219 (21%), Positives = 83/219 (37%), Gaps = 54/219 (24%) Query: 274 RDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVI 333 +D + SLL +S DG + D+ I + I G T++S+S ++ L P Sbjct: 235 KDDVMSLLANSKL-DGNYIDDKYINAYYVAIATAGHDTTSSSSGGAIIGLSRNP------ 287 Query: 334 YQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETN 393 E + L K D +P + + E +R P+ S R + N Sbjct: 288 --EQLALAKS-----------DPALIPRL---VDEAVRWTAPVKSFMRTALADTEVRGQN 331 Query: 394 YIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVS 453 + +G +++S A+ E F NP++FD TR+ Sbjct: 332 --IKRGDRIMLSYPSANRDEEVFSNPDEFDITRF-------------------------- 363 Query: 454 KGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLR 492 + +L FG G H C+G+ A +++ + L+ Sbjct: 364 ---PNRHLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLK 399 >6HQW-A nrPDB Length = 445 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 50/218 (22%), Positives = 84/218 (38%), Gaps = 55/218 (25%) Query: 267 RGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEK 326 R P+ DLI S++IHS + M+ QE L+ +++GG T+ +T + + L + Sbjct: 246 RMQAPPSGDLI-SMMIHSEAMN--HMSPQEFMGNLVLLIVGGNDTTRNTMSGIVHALDKF 302 Query: 327 PHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNP 386 P D +L D +P N ++E +R PL + R T Sbjct: 303 P-------------------DQRELLERDASLIP---NAVQECIRYVTPLAHMRRTATAD 340 Query: 387 LRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVD 446 + + G V++ A+ E F+NP+ Sbjct: 341 TEL--FGNQIKAGEKVILWYISANRDETVFENPDKL------------------------ 374 Query: 447 YGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTIL 484 V + + +L FG G HRC+G + A +QL +L Sbjct: 375 ----MVDRPNARRHLSFGHGIHRCVGARLAELQLRILL 408 >6A7J-A nrPDB Length = 411 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 51/224 (22%), Positives = 82/224 (36%), Gaps = 57/224 (25%) Query: 266 ERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGE 325 E +P DL +L+ S +DG +TD+EI N L I+ G T+ S + L Sbjct: 201 EEKKANPGDDLTSALIAAS--EDGDHLTDEEILNTLQLIIAAGHETTISLIVNVVEALAI 258 Query: 326 KPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPL-HSIFRKVT 384 P + + ++ +E I+ETLR + P H + R T Sbjct: 259 HPEQRKKVLS-------------GEIPWE---------GVIEETLRWNTPTSHVLIRFAT 296 Query: 385 NPLRIPETNYIVPKGHYVLVSPG-YAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSD 443 + + + ++PKG ++VS G E+Y DFD TR Sbjct: 297 EDIEV--GDKVLPKGEGLVVSFGALGRDEEQYGPTAGDFDATR----------------- 337 Query: 444 EVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTF 487 + ++ FG G H C G + ++ G L Sbjct: 338 ------------TPNRHIAFGHGPHVCPGAALSRLEAGIALPAL 369 >4XE3-A nrPDB Length = 407 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 54/232 (23%), Positives = 88/232 (37%), Gaps = 56/232 (24%) Query: 257 YMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTS 316 YM + ++R P DL+ +L + + D +T EI N+ + +L+ G TS + Sbjct: 199 YMDGLVAQRRDA---PTEDLLGALALATDNDD--HLTKGEIVNMGVSLLIAGHETSVN-Q 252 Query: 317 AWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPL 376 L+HL LL E+ YE L P++ E + + PL Sbjct: 253 ITNLVHL----------------LLTERK------RYESLVADPALVPAAVEEMLRYTPL 290 Query: 377 HSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANS 436 V G +V V+ S E P A+A + Sbjct: 291 -------------------VSAGSFVRVATEDVELSTVTVRAGE---PCVVHFASANRDE 328 Query: 437 VSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFV 488 F+ +DE+D+ + +P++ FG G H CIG Q ++L L+ V Sbjct: 329 EVFDHADELDFHRER------NPHIAFGHGAHHCIGAQLGRLELQEALSALV 374 >5GWE-A nrPDB Length = 405 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 76/352 (21%), Positives = 128/352 (36%), Gaps = 91/352 (25%) Query: 143 KKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHG--VANVMKTQPEITIFT- 199 + A+ A T +K P IR +++ E ++ G V+++ P ITI T Sbjct: 97 RAIAQKAFTPRRYKALEPDIRAMVIDRV---EKMLANDQHVGDMVSDLAYDIPTITILTL 153 Query: 200 --ASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPH----YWRRDAAQKKI 253 A S+ D +R D A + DL +P H YW+ Q+ + Sbjct: 154 IGADISMV-DTYKRWSDSRAAMTWGDLSDE--------EQIPHAHNLVEYWQE--CQRMV 202 Query: 254 SATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSA 313 + + G + DL+ + ++G ++TD EIA+LL +L G T+ Sbjct: 203 ADAHA--------HGGDNLTADLVRA------QQEGQEITDHEIASLLYSLLFAGHETTT 248 Query: 314 S-TSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRM 372 + S F + L Q ++ E+ + +P+ + E LR Sbjct: 249 TLISNCFRVLLDHPEQWQAIL--------------------ENPKLIPAA---VDEVLRY 285 Query: 373 HMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAA 432 + RK I + +G VL+ G A+ E F+N E+FD Sbjct: 286 SGSIVGWRRKALKDTEI--GGVAIKEGDGVLLLMGSANRDEARFENGEEFD--------- 334 Query: 433 KANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTIL 484 +S+ + +L FG G H C+G A +Q L Sbjct: 335 -------------------ISRANAREHLSFGFGIHYCLGNMLAKLQAKICL 367 >6A7I-A nrPDB Length = 411 Score = 41.6 bits (96), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 56/237 (23%), Positives = 92/237 (38%), Gaps = 61/237 (25%) Query: 253 ISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTS 312 + A + K + ++R +P DL +L+ S ++G +TD+EI N L I+ G T+ Sbjct: 192 LGALFTKIVDAKR----TNPGDDLTSALIAAS--ENGDHLTDEEIVNTLQLIIAAGHETT 245 Query: 313 ASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRM 372 S ++++ E LQ Q L E G D I+ETLR Sbjct: 246 IS----LIVNVVEA--LQTHPEQRKKVLNGEIGWD----------------GVIEETLRW 283 Query: 373 HMPL-HSIFRKVTNPLRIPETNYIVPKGHYVLVSPG-YAHTSERYFDNPEDFDPTRWDTA 430 + P H + R T + + + I+PKG +++S G E+Y +FD TR Sbjct: 284 NTPTSHVLIRFATEDIEV--GDKILPKGEGLIISFGALGRDEEQYGPTAGEFDATR---- 337 Query: 431 AAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTF 487 + ++ FG G H C G + ++ G L Sbjct: 338 -------------------------TPNRHIAFGHGPHVCPGAALSRLEAGIALPAL 369 >5XJN-A nrPDB Length = 455 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 76/352 (21%), Positives = 127/352 (36%), Gaps = 91/352 (25%) Query: 143 KKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHG--VANVMKTQPEITIFT- 199 + A+ A T +K P IR +++ E ++ G V+++ P ITI T Sbjct: 147 RAIAQKAFTPRRYKALEPDIRAMVIDRV---EKMLANDQHVGDMVSDLAYDIPTITILTL 203 Query: 200 --ASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPH----YWRRDAAQKKI 253 A S+ D +R D A + DL +P H YW+ Q+ + Sbjct: 204 IGADISMV-DTYKRWSDSRAAMTWGDLSDE--------EQIPHAHNLVEYWQE--CQRMV 252 Query: 254 SATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSA 313 + + G + DL+ ++G ++TD EIA+LL +L G T+ Sbjct: 253 ADAHA--------HGGDNLTADLV------RAQQEGQEITDHEIASLLYSLLFAGHETTT 298 Query: 314 S-TSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRM 372 + S F + L Q ++ E+ + +P+ + E LR Sbjct: 299 TLISNCFRVLLDHPEQWQAIL--------------------ENPKLIPAA---VDEVLRY 335 Query: 373 HMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAA 432 + RK I + +G VL+ G A+ E F+N E+FD Sbjct: 336 SGSIVGWRRKALKDTEI--GGVAIKEGDGVLLLMGSANRDEARFENGEEFD--------- 384 Query: 433 KANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTIL 484 +S+ + +L FG G H C+G A +Q L Sbjct: 385 -------------------ISRANAREHLSFGFGIHYCLGNMLAKLQAKICL 417 >4ZGX-A nrPDB Length = 489 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 38/168 (22%), Positives = 66/168 (39%), Gaps = 27/168 (16%) Query: 307 GGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTI 366 G T+A L L P +Q ++ QE + +++ + +LP + + Sbjct: 291 GSVDTTAFPLLMTLFELARNPDVQQILRQESLA----AAASISEHPQKATTELPLLRAAL 346 Query: 367 KETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTR 426 KETLR++ + R V++ L + NY +P G V V + F PE ++P R Sbjct: 347 KETLRLYPVGLFLERVVSSDLVL--QNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQR 404 Query: 427 WDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQ 474 W G + ++PFG G +C+G + Sbjct: 405 W---------------------LDIRGSGRNFHHVPFGFGMRQCLGRR 431 >6DCD-A nrPDB Length = 424 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 40/162 (24%), Positives = 66/162 (40%), Gaps = 29/162 (17%) Query: 261 IKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFL 320 I+ RR + P D++ +L +TY DG ++ + GQ T+A + Sbjct: 211 IEDRRRQ----PRNDVLTALAT-ATYPDGSTPEVIDVVRSATFLFAAGQETTAKLLTAAM 265 Query: 321 LHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIF 380 LG++P +Q + E+ +P N I+E+LRM P+ S Sbjct: 266 RVLGDRPDIQRRL-------------------RENRSLIP---NFIEESLRMDSPVKSDS 303 Query: 381 RKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDF 422 R R + G V+V PG A+ R F++P +F Sbjct: 304 RLARK--RTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEF 343 >4Z5Q-A nrPDB Length = 423 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 52/231 (22%), Positives = 90/231 (38%), Gaps = 57/231 (24%) Query: 261 IKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFL 320 +K RR +P DL +L+ D ++ + E+ L I IL+GG T+AS + F+ Sbjct: 223 VKERR----AEPRDDLTSALIEARDAHD--RLAEPELIGLCISILIGGFETTASEISSFV 276 Query: 321 LHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIF 380 L ++ L + D + +P+ ++E LR +P + Sbjct: 277 HVLQQRRELWTRLCA-------------------DPEAIPA---AVEELLRF-VPFAA-- 311 Query: 381 RKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFN 440 N I P+ ++ G E +P DT+A + + F+ Sbjct: 312 ------------NGISPRYALEDMTVGGVLVRE--------GEPVIVDTSAVNRDGLVFD 351 Query: 441 SSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL 491 ++DEV V + ++ FG G H C+G A V+L L V + Sbjct: 352 NADEV------VIDRADNRHMVFGHGAHHCLGAHLARVELQEALKALVEGM 396 >5H1Z-A nrPDB Length = 407 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 54/215 (25%), Positives = 85/215 (39%), Gaps = 59/215 (27%) Query: 272 PNRDLIDSLLIHSTYKDGVKMTDQ-EIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQ 330 P DLI S++IHS D + DQ E LI +++GG T+ +T + Sbjct: 213 PTPDLI-SMMIHS---DAMAEMDQMEFLGNLILLIVGGNDTTRNT-------------MS 255 Query: 331 DVIYQEVVELLKEKGGDLNDLTYEDLQKLPS-VNNTIKETLRMHMPLHSIFRKVTNPLRI 389 V Y G DL L+ PS + NT++E +R PL + R T + Sbjct: 256 AVAY----------GLDLFPDQRAKLEADPSMIPNTVQEIIRWQTPLAHMRRTATVDSEL 305 Query: 390 PETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGF 449 +G + A W +A + SV F ++D + Sbjct: 306 --------EGQQIKAGDKLAL----------------WYISANRDESV-FENADRI---- 336 Query: 450 GKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTIL 484 V + + +L FG G HRC+G + A +Q+ +L Sbjct: 337 -IVDRPNARRHLAFGHGIHRCVGARLAELQIAVLL 370 >3DBM-A nrPDB Length = 473 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 33/140 (23%), Positives = 64/140 (45%), Gaps = 11/140 (7%) Query: 294 DQEIANLLIGILM----GGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLN 349 D+ + N+L + G + +T W L GE H Q + +E+ +K G Sbjct: 263 DEAVHNILFAVCFNTFGGVKILFPNTLKWIGLA-GENLHTQ--LAEEIRGAIKSYGD--G 317 Query: 350 DLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIP--ETNYIVPKGHYVLVSPG 407 ++T E ++++P + + E+LR+ P+ + K + I + + V KG + Sbjct: 318 NVTLEAIEQMPLTKSVVYESLRIEPPVPPQYGKAKSNFTIESHDATFEVKKGEMLFGYQP 377 Query: 408 YAHTSERYFDNPEDFDPTRW 427 +A + FD PE++ P R+ Sbjct: 378 FATKDPKVFDRPEEYVPDRF 397 >3WVS-A nrPDB Length = 401 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 57/234 (24%), Positives = 93/234 (39%), Gaps = 63/234 (26%) Query: 261 IKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFL 320 I +RR + P DLI ++ +D K+T+QE+ + IG+L+ G T+AS F+ Sbjct: 201 IAARRAQ----PADDLISGMIEARDVQD--KLTEQELLDHCIGLLIAGHETTASQIPSFV 254 Query: 321 LHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHS-- 378 L ++P Q LL +D + +PS ++E R +PL S Sbjct: 255 YALLDQP-------QHWKRLL------------DDPELIPS---AVEELFRF-VPLGSGS 291 Query: 379 -IFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSV 437 R + + T +V G VLV+ G A+ F++PE+ R Sbjct: 292 AAPRYAREDIEVGGT--LVRAGEPVLVALGAANRDGLRFEDPEEIKLDR----------- 338 Query: 438 SFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL 491 S+ ++ FG G H C+G A ++L L + L Sbjct: 339 ------------------PSNHHIGFGHGIHHCLGAPLARLELQEALRALLERL 374 >4Z5P-A nrPDB Length = 400 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 56/245 (22%), Positives = 94/245 (38%), Gaps = 63/245 (25%) Query: 248 AAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMG 307 +A I A + +RR P+ DL+ L+ S D ++T+ E+ + +L+ Sbjct: 184 SADASIRAYLADLVSARR----AAPHDDLLGVLV--SARDDDDRLTEDELITFGVTLLVA 237 Query: 308 GQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIK 367 G TSA + L + +++ + LL+E+ + LP ++ Sbjct: 238 GHETSAHQLGNMVYAL--------LTHEDQLSLLREQP-----------ELLP---RAVE 275 Query: 368 ETLRMHMPLHSIFRKVTNPLRIPE-TNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTR 426 E LR +PL + L E + V G V+ + A+ R FD+P+ D TR Sbjct: 276 ELLRF-VPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLDITR 334 Query: 427 WDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQL----GT 482 +P+L FG G H C+G Q A ++L G Sbjct: 335 E-----------------------------KNPHLAFGHGAHYCLGAQLARMELRVAIGG 365 Query: 483 ILTTF 487 +L F Sbjct: 366 LLERF 370 >2FR7-A nrPDB Length = 412 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 51/258 (19%), Positives = 96/258 (37%), Gaps = 61/258 (23%) Query: 232 NFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVK 291 VF P+ R+ A ++ SA + + + +R ++ P IH+ + D + Sbjct: 182 GLVFNAFGPPNELRQSAIER--SAPHQAYVAEQCQRPNLAPGGF---GACIHA-FSDTGE 235 Query: 292 MTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDL 351 +T +E L+ +L G T+ + A + L P Sbjct: 236 ITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPD----------------------- 272 Query: 352 TYEDLQKLPSV-NNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAH 410 + L+ PS+ N +E +R P+ + FR T + + + +G VL+ G A+ Sbjct: 273 EFARLRADPSLARNAFEEAVRFESPVQTFFRTTTRDVEL--AGATIGEGEKVLMFLGSAN 330 Query: 411 TSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRC 470 R +D+P+ +D TR +S ++ FG G H C Sbjct: 331 RDPRRWDDPDRYDITRK-----------------------------TSGHVGFGSGVHMC 361 Query: 471 IGEQFAYVQLGTILTTFV 488 +G+ A ++ +L Sbjct: 362 VGQLVARLEGEVVLAALA 379 >6M7X-A nrPDB Length = 484 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 35/155 (22%), Positives = 63/155 (40%), Gaps = 27/155 (17%) Query: 320 LLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSI 379 L L P++Q + QE + +++ + +LP + +KETLR++ P+ Sbjct: 304 LFELARNPNVQQALRQESLA----AAASISEHPQKATTELPLLRAALKETLRLY-PVGLF 358 Query: 380 FRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSF 439 +V + + + NY +P G V V + F PE ++P RW + Sbjct: 359 LERVASSDLVLQ-NYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRW---------LDI 408 Query: 440 NSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQ 474 S Y ++PFG G +C+G + Sbjct: 409 RGSGRNFY------------HVPFGFGMRQCLGRR 431 >5IT1-A nrPDB Length = 399 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 57/243 (23%), Positives = 90/243 (37%), Gaps = 62/243 (25%) Query: 247 DAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILM 306 +AA ++ + ++ RR +P DLI S LI + DGV + D + N +L+ Sbjct: 183 EAAGMRLGGLLYQLVQERRA----NPGDDLI-SALITTEDPDGV-IDDMFLMNAAGTLLI 236 Query: 307 GGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPS-VNNT 365 T+A L ++P + L LQK PS + N Sbjct: 237 AAHDTTACMIGLGTALLLDRP---------------------DQLAL--LQKDPSLIGNA 273 Query: 366 IKETLR-MHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDP 424 ++E LR + + R T I + KG V+ A + ++PE FD Sbjct: 274 VEELLRYLTIGQFGAERVATQDGEI--GGVRIAKGEQVVTHLLSADFDPAFVEDPERFDI 331 Query: 425 TRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTIL 484 TR +P+L FG G H+CIG+Q A ++L + Sbjct: 332 TRR-----------------------------PAPHLAFGFGAHQCIGQQLARIELQIVF 362 Query: 485 TTF 487 T Sbjct: 363 GTL 365 >5VWS-A nrPDB Length = 393 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 82/387 (21%), Positives = 133/387 (34%), Gaps = 92/387 (23%) Query: 122 TTPVFGKGVI--YDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTD---ESF 176 T FGKG I D P R Q++ A T S P+IR +I ++ + + F Sbjct: 69 TAQGFGKGGITMIDPPEHR--HQRRLITHAFTPQSISAMEPRIR-QIADHLLDELPGPEF 125 Query: 177 KLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFP 236 L E V+ + + R LF + +SD N+ P Sbjct: 126 DLVEHFAYPLPVIVIAELLGVPPGDRHLF-------------RTWSDRLMSLQVENYADP 172 Query: 237 NLPLPHYWRRDAAQKKISATYMKE-IKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQ 295 L R AA Y++E +SRR P DL+ L+ +G ++ + Sbjct: 173 ELA-----RTVAAAMTEMNDYLREHCRSRR----THPRDDLLTRLV--QAEVEGKRLDLE 221 Query: 296 EIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYED 355 E+ N +L+ G T+ +L L + P + + + Sbjct: 222 EVVNTASLLLLAGHLTTTVLIGNTMLCLWDHPEAEKAVRAD------------------- 262 Query: 356 LQKLPS-VNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSER 414 PS + ++E+LR+ P R T + I +P +V+ A+ +R Sbjct: 263 ----PSLIPAALEESLRLRSPFLQAGRVTTRDVTI--AGETIPANRFVMAWILSANHDDR 316 Query: 415 YFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQ 474 F +PE FD R T ++ FG G H C+G Q Sbjct: 317 RFPDPERFDLHRQTTG-----------------------------HIAFGHGVHFCLGAQ 347 Query: 475 FAYVQ----LGTILTTFVYNLRWTIDG 497 ++ L +L F W +G Sbjct: 348 LGRLEGRIALERLLGRFTEIHPWPREG 374 >4TRI-A nrPDB Length = 407 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 60/263 (22%), Positives = 106/263 (40%), Gaps = 67/263 (25%) Query: 257 YMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTS 316 + K++ ++R +P DL S+L++S + G +M+D EI + IL+GG T+ T Sbjct: 188 FTKDVITKRR---AEPTDDLF-SVLVNSEVE-GQRMSDDEIVFETLLILIGGDETTRHT- 241 Query: 317 AWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPL 376 L G + +LL+ + D D D+ LP I+E LR P+ Sbjct: 242 ----LSGGTE------------QLLRHR--DQWDALVADVDLLPGA---IEEMLRWTSPV 280 Query: 377 HSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANS 436 ++ R +T T + G +++ A+ E F +P++F Sbjct: 281 KNMCRTLTADTVFHGTE--LRAGEKIMLMFESANFDESVFGDPDNF-------------R 325 Query: 437 VSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTID 496 + N + V +GFG H C+G Q A ++L ++T V Sbjct: 326 IDRNPNSHVAFGFGT----------------HFCLGNQLARLEL-RLMTERVLR------ 362 Query: 497 GYKVPDPDYSSMVVLPTEPAEII 519 ++PD + +P PA + Sbjct: 363 --RLPDLRLADDAPVPLRPANFV 383 >2Y5N-A nrPDB Length = 417 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 50/240 (20%), Positives = 90/240 (37%), Gaps = 64/240 (26%) Query: 256 TYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSAST 315 YM ++ RR + +P DL+ +L+ +D +++QE+ +L IG+L+ G ++ + Sbjct: 208 AYMGDLIDRRRK---EPTDDLVSALVQARDQQD--SLSEQELLDLAIGLLVAGYESTTTQ 262 Query: 316 SAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMP 375 A F+ L +P L+ + D +L +++L + + P Sbjct: 263 IADFVYLLMTRPELRRQLL------------DRPELIPSAVEEL---TRWVPLGVGTAFP 307 Query: 376 LHSI----FRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAA 431 +++ R VT + G VL S G A Sbjct: 308 RYAVEDVTLRGVT-----------IRAGEPVLASTG-----------------------A 333 Query: 432 AKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL 491 A + F +D +D + +L FG G H C+G A V+L L + L Sbjct: 334 ANRDQAQFPDADRIDV------DRTPNQHLGFGHGVHHCLGAPLARVELQVALEVLLQRL 387 >1F4U-A nrPDB Length = 368 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 34/140 (24%), Positives = 50/140 (35%), Gaps = 33/140 (23%) Query: 365 TIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDP 424 I+E LR P+ RK R+ + + +G YV V A+ E F + E F P Sbjct: 243 AIEEALRYSPPVMRTVRKTKE--RVKLGDQTIEEGEYVRVWIASANRDEEVFHDGEKFIP 300 Query: 425 TRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTIL 484 R +P+L FG G H C+G A ++ + Sbjct: 301 DR-----------------------------NPNPHLSFGSGIHLCLGAPLARLEARIAI 331 Query: 485 TTFVYNLRW--TIDGYKVPD 502 F R +D KVP+ Sbjct: 332 EEFSKRFRHIEILDTEKVPN 351 >3ABA-A nrPDB Length = 403 Score = 37.7 bits (86), Expect = 0.014, Method: Compositional matrix adjust. Identities = 55/246 (22%), Positives = 90/246 (36%), Gaps = 60/246 (24%) Query: 247 DAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILM 306 +AA ++ + ++ RR +P DLI S LI + DGV + D + N +L+ Sbjct: 183 EAAGMRLGGLLYQLVQERRA----NPGDDLI-SALITTEDPDGV-VDDMFLMNAAGTLLI 236 Query: 307 GGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPS-VNNT 365 T+A L + P + + LL+E PS V N Sbjct: 237 AAHDTTACMIGLGTALLLDSP--------DQLALLRED---------------PSLVGNA 273 Query: 366 IKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPT 425 ++E LR ++ + + + + KG V+ A + + PE FD T Sbjct: 274 VEELLR-YLTIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDIT 332 Query: 426 RWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILT 485 R +P+L FG G H+CIG+Q A ++L + Sbjct: 333 RR-----------------------------PAPHLAFGFGAHQCIGQQLARIELQIVFE 363 Query: 486 TFVYNL 491 T L Sbjct: 364 TLFRRL 369 >4DO1-A nrPDB Length = 410 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 33/148 (22%), Positives = 60/148 (40%), Gaps = 36/148 (24%) Query: 355 DLQKLPS----VNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAH 410 +LQ+L S N +E +R P+ + FR T + + ++ +G VL+ G A+ Sbjct: 271 ELQRLRSDPTLARNAFEEAVRFESPVQTFFRTTTREVEL--GGAVIGEGEKVLMFLGSAN 328 Query: 411 TSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRC 470 R + +P+ +D TR +S ++ FG G H C Sbjct: 329 RDPRRWSDPDLYDITRK-----------------------------TSGHVGFGSGVHMC 359 Query: 471 IGEQFAYVQLGTILTTFVYNLRWT-IDG 497 +G+ A ++ +L+ + IDG Sbjct: 360 VGQLVARLEGEVMLSALARKVAAIDIDG 387 >4OQS-A nrPDB Length = 433 Score = 37.0 bits (84), Expect = 0.019, Method: Compositional matrix adjust. Identities = 46/224 (20%), Positives = 81/224 (36%), Gaps = 64/224 (28%) Query: 257 YMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTS 316 Y+ E+ + + + P DL+ SL+ + +TD+E+ N+ + +L+ G T+A+ Sbjct: 199 YIAELVATKR---LSPKDDLLGSLITDT------DLTDEELTNIALLLLVAGHETTAN-- 247 Query: 317 AWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPL 376 +L LG LQ + E + L L Y + L + N E + + Sbjct: 248 ---MLGLGTFALLQ---HPEQIAALDSPDAVEELLRYLSIVHLGTPNRAALEDVELE--- 298 Query: 377 HSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANS 436 ++ KG V + + + FD P+ R D A Sbjct: 299 ----------------GQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDRVDARKHAA-- 340 Query: 437 VSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQL 480 FGGG H+C+G+Q A V++ Sbjct: 341 --------------------------FGGGIHQCLGQQLARVEM 358 >1Z8P-A nrPDB Length = 404 Score = 37.0 bits (84), Expect = 0.020, Method: Compositional matrix adjust. Identities = 49/214 (22%), Positives = 77/214 (35%), Gaps = 54/214 (25%) Query: 266 ERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGE 325 ER +P DL+ +L+ DG +++ E+ ++ + +L+ G +S S L Sbjct: 201 ERRRTEPGDDLLSALIRVQDDDDG-RLSADELTSIALVLLLAGFESSVSLIGIGTYLLLT 259 Query: 326 KPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTN 385 P D L D LP N ++E LR P + R Sbjct: 260 HP-------------------DQLALVRRDPSALP---NAVEEILRYIAPPETTTRFAAE 297 Query: 386 PLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEV 445 + I +P+ VLV+ G A+ + F +P FD TR DT Sbjct: 298 EVEI--GGVAIPQYSTVLVANGAANRDPKQFPDPHRFDVTR-DTRG-------------- 340 Query: 446 DYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQ 479 +L FG G H C+G A ++ Sbjct: 341 --------------HLSFGQGIHFCMGRPLAKLE 360 >6G5O-A nrPDB Length = 399 Score = 37.0 bits (84), Expect = 0.021, Method: Compositional matrix adjust. Identities = 47/232 (20%), Positives = 84/232 (36%), Gaps = 57/232 (24%) Query: 261 IKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFL 320 I + +R +P D+ S+L++S + +G K+T +E+ +++ GG+ T + + Sbjct: 176 IDEQIDRASENPGDDMY-SVLLNSEF-EGRKLTKEEVKGVMVLTFAGGRDTVINAVTNSI 233 Query: 321 LHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNN-TIKETLRMHMPLHSI 379 +L E P E L+K P + ++E +R PL + Sbjct: 234 AYLAEHPE-----------------------ALERLRKEPEITGRAVEEMIRYFSPLTQM 270 Query: 380 FRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSF 439 R VT + E + V + + A+ F+NP + R K N Sbjct: 271 GRVVTEDTHVCE--HAVKADSRISLCWASANRDAAVFENPNEIVLDR------KVN---- 318 Query: 440 NSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL 491 P++ FG H C+G A L +L T + Sbjct: 319 -------------------PHVGFGFSHHNCLGATHARQILKILLQTLAQKV 351 >3R9C-A nrPDB Length = 418 Score = 37.0 bits (84), Expect = 0.024, Method: Compositional matrix adjust. Identities = 51/246 (20%), Positives = 84/246 (34%), Gaps = 69/246 (28%) Query: 244 WRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIG 303 W RD Y++ + R R P DL+ L+ + + G ++T+ EI Sbjct: 207 WLRD---------YLRALIDERRR---TPGEDLMSGLV--AVEESGDQLTEDEIIATCNL 252 Query: 304 ILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPS-V 362 +L+ G T+ ++I + +L+ G + L S Sbjct: 253 LLIAGHETTV-----------------NLIANAALAMLRTPG------QWAALAADGSRA 289 Query: 363 NNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDF 422 + I+ET+R P+ + R + L I + VPKG +L+ AH P+ F Sbjct: 290 SAVIEETMRYDPPVQLVSRYAGDDLTI--GTHTVPKGDTMLLLLAAAHRDPTIVGAPDRF 347 Query: 423 DPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGT 482 DP R +L FG G H C+G A ++ Sbjct: 348 DPDRAQIR-----------------------------HLGFGKGAHFCLGAPLARLEATV 378 Query: 483 ILTTFV 488 L Sbjct: 379 ALPALA 384 >6F0B-A nrPDB Length = 395 Score = 36.2 bits (82), Expect = 0.032, Method: Compositional matrix adjust. Identities = 48/225 (21%), Positives = 89/225 (39%), Gaps = 58/225 (25%) Query: 271 DPNRDLIDSL---LIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKP 327 DP+ DSL L+ Y++ ++T E +++ +++GG T+AST + L+ +P Sbjct: 195 DPSELPEDSLIRRLVTGPYQEK-QLTFHETIGVILMLIVGGYDTTASTISLSLVSYALQP 253 Query: 328 HLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMH-MPLHSIFRKVTNP 386 V++ E +++P + ++E LR H + + R T Sbjct: 254 EKFSVVH-------------------EHPERIPLL---VEELLRYHTVSQLGLGRIATED 291 Query: 387 LRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVD 446 + + V G V+ + A+ E F NP++ D R Sbjct: 292 VEV--GGVTVRAGQMVVAALPLANRDESVFPNPDELDFDRP------------------- 330 Query: 447 YGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL 491 S P++ FG G H+C+G+ A V+L + + L Sbjct: 331 ----------SVPHVGFGYGPHQCVGQALARVELQEAIPAVIRRL 365 >3ABB-A nrPDB Length = 408 Score = 36.2 bits (82), Expect = 0.033, Method: Compositional matrix adjust. Identities = 53/249 (21%), Positives = 92/249 (36%), Gaps = 61/249 (24%) Query: 256 TYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSAST 315 TY+ + R++ +P L+D L I ++G + E+ + + +L+ G T+ + Sbjct: 197 TYLHGLVGRKQ---AEPEDGLLDEL-IARQLEEG-DLDHDEVVMIALVLLVAGHETTVNA 251 Query: 316 SAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMP 375 A L L + P DV LL++ G +V+ ++E LR Sbjct: 252 IALGALTLIQHPEQIDV-------LLRDPG---------------AVSGVVEELLRFTSV 289 Query: 376 LHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKAN 435 I R + + + G VLVS + + ++NP+ FD R Sbjct: 290 SDHIVRMAKEDIEV--GGATIKAGDAVLVSITLMNRDAKAYENPDIFDARR--------- 338 Query: 436 SVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTF---VYNLR 492 N+ V FG G H+C+G+ A +L L + LR Sbjct: 339 ----NARHHVG----------------FGHGIHQCLGQNLARAELEIALGGLFARIPGLR 378 Query: 493 WTIDGYKVP 501 + +VP Sbjct: 379 LAVPLDEVP 387 >6HQG-A nrPDB Length = 425 Score = 36.2 bits (82), Expect = 0.034, Method: Compositional matrix adjust. Identities = 51/218 (23%), Positives = 82/218 (37%), Gaps = 55/218 (25%) Query: 266 ERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGE 325 ER + P DLI S+L H + M E LI +++GG T+ +T + +L L + Sbjct: 224 ERVNAPPKPDLI-SMLAHG--ESTKNMDRMEYLGNLILLIVGGNDTTRNTISGSVLALHQ 280 Query: 326 KPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTN 385 P QD L+E G +P++ + ET+R PL + R+ Sbjct: 281 NPD-QD-------RKLRENPG-----------LIPAM---VSETIRWQTPLAYMRRRAKR 318 Query: 386 PLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEV 445 + + +G V + + E D P D+ W Sbjct: 319 DFEL--GGKTIREGDKVAMWYVSGNRDEEVIDRPNDY----W------------------ 354 Query: 446 DYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTI 483 + + +L FG G HRC+G + A +QL I Sbjct: 355 ------IERPRVRQHLSFGFGVHRCVGNRLAELQLKII 386 >2RFC-A nrPDB Length = 343 Score = 36.2 bits (82), Expect = 0.037, Method: Compositional matrix adjust. Identities = 46/227 (20%), Positives = 85/227 (37%), Gaps = 65/227 (28%) Query: 277 IDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQE 336 I ++L S+ K+ D++I +++ +++GG T+ + + + E P + D Sbjct: 159 IINVLAGSSLKNRKLTMDEKIKYIML-LIIGGNETTTNLIGNMIRVIDENPDIID----- 212 Query: 337 VVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYI- 395 + LK + G ++ETLR + P+ + + E +YI Sbjct: 213 --DALKNRSG------------------FVEETLRYYSPIQFLPHRFA-----AEDSYIN 247 Query: 396 ---VPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKV 452 + KG V+V G A+ E +FD P+ F R + Sbjct: 248 NKKIKKGDQVIVYLGSANRDETFFDEPDLFKIGRREM----------------------- 284 Query: 453 SKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYK 499 +L FG G H C+G A ++ L + + + YK Sbjct: 285 -------HLAFGIGIHMCLGAPLARLEASIALNDILNHFKRIKIDYK 324 >4OQR-A nrPDB Length = 457 Score = 36.2 bits (82), Expect = 0.039, Method: Compositional matrix adjust. Identities = 46/224 (20%), Positives = 81/224 (36%), Gaps = 64/224 (28%) Query: 257 YMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTS 316 Y+ E+ + + + P DL+ SL+ + +TD+E+ N+ + +L+ G T+A+ Sbjct: 238 YIAELVATKR---LSPKDDLLGSLITDT------DLTDEELTNIALILLVAGHETTAN-- 286 Query: 317 AWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPL 376 +L LG LQ + E + L L Y + L + N E + + Sbjct: 287 ---MLGLGTFALLQ---HPEQIANLDSPDAVEELLRYLSIVHLGTPNRAALEDVELE--- 337 Query: 377 HSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANS 436 ++ KG V + + + FD P+ R D A Sbjct: 338 ----------------GQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDRVDARKHAA-- 379 Query: 437 VSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQL 480 FGGG H+C+G+Q A V++ Sbjct: 380 --------------------------FGGGIHQCLGQQLARVEM 397 >3TYW-A nrPDB Length = 417 Score = 35.8 bits (81), Expect = 0.042, Method: Compositional matrix adjust. Identities = 56/236 (23%), Positives = 90/236 (38%), Gaps = 68/236 (28%) Query: 261 IKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFL 320 + RRE +P DLI S L+ G T+Q ++ L I I G+ T+ S A Sbjct: 209 VAERRE----EPRDDLI-SKLVTDHLVPGNVTTEQLLSTLGITI-NAGRETTTSMIALST 262 Query: 321 LHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIF 380 L L ++P L EL K+ DL ++L ++ SV ++I Sbjct: 263 LLLLDRPELP-------AELRKDP--DLMPAAVDELLRVLSVADSI-------------- 299 Query: 381 RKVTNPLRIPE-----TNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKAN 435 PLR+ + VP V+ A+ FD+PE D Sbjct: 300 -----PLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVD------------ 342 Query: 436 SVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL 491 F+ +D + ++ FG G H+C+G+ A ++L L T + + Sbjct: 343 ---FHRTD--------------NHHVAFGYGVHQCVGQHLARLELEVALETLLRRV 381 >3RWL-A nrPDB Length = 426 Score = 35.4 bits (80), Expect = 0.057, Method: Compositional matrix adjust. Identities = 50/227 (22%), Positives = 82/227 (36%), Gaps = 61/227 (26%) Query: 266 ERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGE 325 ER + DP DLI S+L HS MT +E ++ +++GG T+ ++ +L L + Sbjct: 227 ERVNKDPGNDLI-SMLAHSPATR--NMTPEEYLGNVLLLIVGGNDTTRNSMTGGVLALHK 283 Query: 326 KPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPS-VNNTIKETLRMHMPLHSIFRKVT 384 P + L+ P+ V + E +R PL + R Sbjct: 284 NPD-----------------------QFAKLKANPALVETMVPEIIRWQTPLAHMRRTAI 320 Query: 385 NPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDE 444 + + KG V++ + + D PE+F Sbjct: 321 ADSEL--GGKTIRKGDKVVMWYYSGNRDDEVIDRPEEF---------------------- 356 Query: 445 VDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQL----GTILTTF 487 + + +L FG G HRC+G + A +QL ILT F Sbjct: 357 ------IIDRPRPRQHLSFGFGIHRCVGNRLAEMQLRILWEEILTRF 397 >1EHE-A nrPDB Length = 403 Score = 35.0 bits (79), Expect = 0.071, Method: Compositional matrix adjust. Identities = 47/223 (21%), Positives = 80/223 (35%), Gaps = 54/223 (24%) Query: 266 ERGDIDPNRDLIDSLLIHSTYKDGVKMTDQ-EIANLLIGILMGGQHTSASTSAWFLLHLG 324 E+ ++P D+I L + +D +IA LL L+ G T + A + L Sbjct: 200 EQRLVEPKDDIISKLCTEQVKPGNIDKSDAVQIAFLL---LVAGNATMVNMIALGVATLA 256 Query: 325 EKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVT 384 + P D + Q L+ PS+ E L + ++ K T Sbjct: 257 QHP---DQLAQ--------------------LKANPSLAPQFVEELCRYHTASALAIKRT 293 Query: 385 NPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDE 444 + + +V ++ S A+ E F+NP++F+ R + D Sbjct: 294 AKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNR-----------KWPPQDP 342 Query: 445 VDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTF 487 + +GFG HRCI E A +L T+ +T Sbjct: 343 LGFGFGD----------------HRCIAEHLAKAELTTVFSTL 369 >5YSW-A nrPDB Length = 441 Score = 35.0 bits (79), Expect = 0.081, Method: Compositional matrix adjust. Identities = 53/234 (22%), Positives = 89/234 (38%), Gaps = 58/234 (24%) Query: 271 DPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQ 330 +P D+I L+ H+ +TD E+ N+ +L+ G T+AS + L ++P Sbjct: 243 NPAGDIISGLIHHAGADPA--LTDDELINIANLLLIAGYDTTASMLGLGIFVLLQRP--- 297 Query: 331 DVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIP 390 + L++ + D E L+ L VN IFR L Sbjct: 298 -----AQLATLRDDPSRIADAVEELLRYLSVVNP-------------GIFRFAKEDLEFA 339 Query: 391 ETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFG 450 + +P G V+VS + R++ +P D D TR Sbjct: 340 GEH--IPAGSTVVVSVVATNRDARHWPDP-DLDLTR------------------------ 372 Query: 451 KVSKGVSSPYLPFGGGRHRCIGEQFAYVQLG---TILTTFVYNLRWTIDGYKVP 501 P+L FG G H+C+G+Q A +++ L + N+R + +VP Sbjct: 373 -----PRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRLAVPPEEVP 421 >6M7L-A nrPDB Length = 404 Score = 35.0 bits (79), Expect = 0.090, Method: Compositional matrix adjust. Identities = 58/264 (21%), Positives = 97/264 (36%), Gaps = 69/264 (26%) Query: 256 TYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSAST 315 YM+E+ +R R DP D +L G ++D+E+A L ++ + S Sbjct: 200 AYMRELAARLRR---DPG----DGMLGMVARDHGADISDEELAGLCAVVMNSSVEQTESC 252 Query: 316 SAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMP 375 A L L E P E LL+E+ +L + E++ + SV + Sbjct: 253 LAAGTLLLLEHP--------EQFALLRERP-ELGEQAVEEIVRYLSVFEGLDP------- 296 Query: 376 LHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKAN 435 R T + I ++ KG V S A+ ++ D FD TR + Sbjct: 297 -----RTATEDVEI--GGQVIKKGEAVFCSLLAANRADPALDG---FDITRKE------- 339 Query: 436 SVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVY---NLR 492 S ++ FG G H C+G A ++L TT V +LR Sbjct: 340 ----------------------SRHVAFGHGIHHCLGAPLARMELRIAFTTLVSRFPSLR 377 Query: 493 WTIDG----YKVPDPDYSSMVVLP 512 + ++ P + +++ LP Sbjct: 378 TAVPAEEIRFRPPSSNVFTLLELP 401 >5LIE-A nrPDB Length = 414 Score = 34.3 bits (77), Expect = 0.14, Method: Compositional matrix adjust. Identities = 48/212 (22%), Positives = 82/212 (38%), Gaps = 56/212 (26%) Query: 271 DPNRDLIDSLLIHSTYKD--GVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPH 328 +P D++ S++ ++T D ++D E+ + G T+ ++ A LL L E P Sbjct: 216 EPADDML-SVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENP- 273 Query: 329 LQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLR 388 + ++ L+ D + LP+ I+E +R P S R + + Sbjct: 274 -------DQLQTLRS-----------DFELLPTA---IEEIVRWTSPSPSKRRTASRAVS 312 Query: 389 IPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYG 448 + + G V+V G A+ FD ++FD TR K N Sbjct: 313 L--GGQPIEAGQKVVVWEGSANRDPSVFDRADEFDITR------KPN------------- 351 Query: 449 FGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQL 480 P+L FG G H C+G A ++L Sbjct: 352 ----------PHLGFGQGVHYCLGANLARLEL 373 >5HDI-A nrPDB Length = 404 Score = 34.3 bits (77), Expect = 0.15, Method: Compositional matrix adjust. Identities = 29/119 (24%), Positives = 45/119 (37%), Gaps = 30/119 (25%) Query: 366 IKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPT 425 I+ETLR P +R V N + T +P ++L+ G A+ F+ P +F Sbjct: 281 IEETLRYEPPFRGHYRHVRNATTLDGTE--LPADSHLLLLWGAANRDPAQFEAPGEF--- 335 Query: 426 RWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTIL 484 R D A K ++ FG G H C+G A ++ +L Sbjct: 336 RLDRAGGKG-------------------------HISFGKGAHFCVGAALARLEARIVL 369 >6GII-A nrPDB Length = 479 Score = 33.9 bits (76), Expect = 0.17, Method: Compositional matrix adjust. Identities = 25/125 (20%), Positives = 48/125 (38%), Gaps = 30/125 (24%) Query: 367 KETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTR 426 +E LR + P+ R+ T + + +P G +L+ A+ +FD+PE FD Sbjct: 346 EECLRYNGPVAGWRRRTTREVEVEGVR--LPVGANILMVVASANHDSAHFDDPEFFD--- 400 Query: 427 WDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTT 486 + + +S +L FG G H+C+G +++ ++ Sbjct: 401 -------------------------IGRSNASEHLNFGYGAHQCLGRNLGRMEMQIMIEE 435 Query: 487 FVYNL 491 L Sbjct: 436 LSRRL 440 >3TKT-A nrPDB Length = 450 Score = 33.1 bits (74), Expect = 0.27, Method: Compositional matrix adjust. Identities = 35/193 (18%), Positives = 67/193 (34%), Gaps = 34/193 (17%) Query: 296 EIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYED 355 ++A ++ ++ G+ S +A + + H L + DL D Sbjct: 259 DVATVIANAVVDGEPMSDRDTAGYYIITASAGHDTTSASSAGAALALARDPDLFARVKAD 318 Query: 356 LQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERY 415 LP + ++E +R P+ R + + G +++++ A+ Sbjct: 319 RNLLPGI---VEEAIRWTTPVQHFMRTAATDTEL--CGQKIAAGDWLMLNYVAANHDPAQ 373 Query: 416 FDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQF 475 F P FDPTR AN +L FG G H+C+G Sbjct: 374 FPEPRKFDPTR------PANR-----------------------HLAFGAGSHQCLGLHL 404 Query: 476 AYVQLGTILTTFV 488 A +++ +L + Sbjct: 405 ARLEMRVLLDVLL 417 >4A05-A nrPDB Length = 364 Score = 33.1 bits (74), Expect = 0.27, Method: Compositional matrix adjust. Identities = 21/89 (23%), Positives = 44/89 (49%), Gaps = 11/89 (12%) Query: 84 SFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQK 143 SF L + +TV + +F+ L+++ A + + P G V+YD P+ Sbjct: 48 SFQWLDRNVTV-------DTLFSGTLAEIRAANQ-RGANPPYAGIFVVYDLPDRDCAAAA 99 Query: 144 KFAKFALT---TDSFKRYVPKIREEILNY 169 ++++ +++KRY+ +IRE ++ Y Sbjct: 100 SNGEWSIANNGANNYKRYIDRIRELLIQY 128 >1GWI-A nrPDB Length = 411 Score = 33.1 bits (74), Expect = 0.32, Method: Compositional matrix adjust. Identities = 47/218 (21%), Positives = 77/218 (35%), Gaps = 56/218 (25%) Query: 272 PNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQD 331 P DL +L+ S ++G +TD EI + L ++ G T+ S +++L P + Sbjct: 209 PGDDLTSALIQAS--ENGDHLTDAEIVSTLQLMVAAGHETTISLIVNAVVNLSTHPEQRA 266 Query: 332 VIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPL-HSIFRKVTNPLRIP 390 ++ E + ++ETLR P H + R +P Sbjct: 267 LVLSGEAEW----------------------SAVVEETLRFSTPTSHVLIRFAAE--DVP 302 Query: 391 ETNYIVPKGHYVLVSPGYAHTSERYFDNPED-FDPTRWDTAAAKANSVSFNSSDEVDYGF 449 + ++P G ++VS G ER D FD TR S N Sbjct: 303 VGDRVIPAGDALIVSYGALGRDERAHGPTADRFDLTR----------TSGNR-------- 344 Query: 450 GKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTF 487 ++ FG G H C G + ++ G L Sbjct: 345 ----------HISFGHGPHVCPGAALSRMEAGVALPAL 372 >5XNT-A nrPDB Length = 411 Score = 32.7 bits (73), Expect = 0.42, Method: Compositional matrix adjust. Identities = 50/230 (21%), Positives = 88/230 (38%), Gaps = 67/230 (29%) Query: 270 IDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSA---STSAWFLLHLGEK 326 ++P D+I LL DG TD E+ + IL G T++ + S + LL+ ++ Sbjct: 208 LNPADDIISDLLKAEV--DGEMFTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYDDKE 265 Query: 327 PHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNP 386 +YQE+ +E+L +P ++E LR L + R V Sbjct: 266 ------VYQEL---------------HENLDLVP---QAVEEMLRYRFNLIKLDRTVK-- 299 Query: 387 LRIPETNYIV----PKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSS 442 E N ++ +G V+V A+ E F++ + + N Sbjct: 300 ----EDNDLLGVELKEGENVVVWMSAANLDEEMFED-----------------AFTLN-- 336 Query: 443 DEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLR 492 + + + +L FG G H C+G A ++ LTTF+ + Sbjct: 337 ---------IHRPNNKKHLTFGNGPHFCLGAPLARLEAKIALTTFLKKFK 377 >1UED-A nrPDB Length = 406 Score = 32.7 bits (73), Expect = 0.42, Method: Compositional matrix adjust. Identities = 55/236 (23%), Positives = 84/236 (35%), Gaps = 64/236 (27%) Query: 249 AQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGG 308 A+ SA + + + + R DP+ D LL G +TD+E+ L +++GG Sbjct: 191 ARAADSAAFNRYLDNLLARQRADPD----DGLLGMIVRDHGDNVTDEELKGLCTALILGG 246 Query: 309 QHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKE 368 T A + +L L + P +ELL +E +K V N E Sbjct: 247 VETVAGMIGFGVLALLDNPG--------QIELL-----------FESPEKAERVVN---E 284 Query: 369 TLRMHMPLHSIFRKVTNP-LRIPET---NYIVPKGHYVLVSPGYAHTSERYFDNPEDFDP 424 +R P+ + NP L I + ++ G YVL S A+ E +P+ D Sbjct: 285 LVRYLSPVQA-----PNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDPDVLDA 339 Query: 425 TRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQL 480 R + D GFG G H C+G A L Sbjct: 340 NRAAVS---------------DVGFGH--------------GIHYCVGAALARSML 366 >1M6J-A nrPDB Length = 261 Score = 31.6 bits (70), Expect = 0.94, Method: Compositional matrix adjust. Identities = 20/80 (25%), Positives = 35/80 (43%), Gaps = 1/80 (1%) Query: 1 MAIVETVIDGINYFLSLSVTQQISILLGVPFVY-NLVWQYLYSLRKDRAPLVFYWIPWFG 59 +A +ET+ G+ + + +++ +++GVPF+Y V Q L LV W Sbjct: 18 LASIETLTKGVAASVDAELAKKVEVIVGVPFIYIPKVQQILAGEANGANILVSAENAWTK 77 Query: 60 SAASYGQQPYEFFESCRQKY 79 S A G+ C+ Y Sbjct: 78 SGAYTGEVHVGMLVDCQVPY 97 >4YZR-A nrPDB Length = 405 Score = 30.8 bits (68), Expect = 1.4, Method: Compositional matrix adjust. Identities = 42/171 (24%), Positives = 76/171 (44%), Gaps = 35/171 (20%) Query: 259 KEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAW 318 K I RR I P DLI S L+H+ ++G K++++E+ ++L +++ G T+ + Sbjct: 199 KLIHDRR----IKPKDDLI-SKLVHAE-ENGSKLSEKELYSMLFLLVVAGLETTVN---- 248 Query: 319 FLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHS 378 LL G LQ +++ E LK Q+ + ++E LR P+ Sbjct: 249 -LLGSGTLALLQ---HKKECEKLK--------------QQPEMIATAVEELLRYTSPV-- 288 Query: 379 IFRKVTNPLRIPETNY---IVPKGHYVLVSPGYAHTSERYFDNPEDFDPTR 426 + N I + Y + +G + + G A+ +F+NPE + R Sbjct: 289 --VMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEILNINR 337 >5KYO-A nrPDB Length = 430 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 28/111 (25%), Positives = 50/111 (45%), Gaps = 15/111 (13%) Query: 261 IKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFL 320 I++RR I P D+I ++ + G +TD E N+ I +L+GG T + + Sbjct: 230 IEARR----IKPGEDMISRMI--NGEVGGRPLTDIEAENICIQVLVGGLDTVVNMLGFTF 283 Query: 321 LHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLR 371 HL + L+ I + ++D E ++ P V++ +E LR Sbjct: 284 SHLAKDHALRRAIAAD--------PSLIDDALLEFFRRFPVVSSA-REVLR 325 >1LG9-A nrPDB Length = 398 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 11/29 (37%), Positives = 17/29 (58%) Query: 459 PYLPFGGGRHRCIGEQFAYVQLGTILTTF 487 P++ FG G H C+G A ++L T+ T Sbjct: 336 PHVAFGHGVHHCLGAALARLELRTVFTEL 364 >5YHJ-A nrPDB Length = 413 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 32/128 (25%), Positives = 44/128 (34%), Gaps = 33/128 (25%) Query: 393 NYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKV 452 Y P+G L+ + + P+ FDP+R F E + F Sbjct: 301 GYAFPEGTLTLLDLYGTNHDVSIWTEPDRFDPSR------------FKDWKESPFNF--- 345 Query: 453 SKGVSSPYLPFGGGR----HRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYS-S 507 +P GGG HRC GE L ++ F Y VP D S S Sbjct: 346 --------IPQGGGDVDFGHRCAGEHVTIAILAQVIELFTKEY-----AYTVPPQDLSYS 392 Query: 508 MVVLPTEP 515 V +P+ P Sbjct: 393 FVDMPSLP 400 >5IJ6-A nrPDB Length = 355 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 15/38 (39%), Positives = 23/38 (60%), Gaps = 1/38 (2%) Query: 3 IVETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYL 40 I+E I G +YF T+ ++ LLGV + Y+ +WQ L Sbjct: 296 IIELTIYG-DYFAKKETTEIVAALLGVDYQYSSIWQAL 332 >2W42-A nrPDB Length = 427 Score = 30.4 bits (67), Expect = 2.2, Method: Compositional matrix adjust. Identities = 25/82 (30%), Positives = 38/82 (46%), Gaps = 10/82 (12%) Query: 213 FDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDP 272 FD +Q+ + +D G I V P P Y+ K+ + + I S+ R DI Sbjct: 93 FDSIKSQVDNAIDTGVDGIMLVLPEYNTPLYY-------KLKSYLINSIPSQFMRYDILS 145 Query: 273 NRDL---IDSLLIHSTYKDGVK 291 NR+L +D+LL+ K G K Sbjct: 146 NRNLTFYVDNLLVQFVSKLGGK 167 >2ZBZ-A nrPDB Length = 412 Score = 30.0 bits (66), Expect = 2.7, Method: Compositional matrix adjust. Identities = 11/29 (37%), Positives = 18/29 (62%) Query: 460 YLPFGGGRHRCIGEQFAYVQLGTILTTFV 488 +L FG G H+C+G+ A ++L IL + Sbjct: 345 HLAFGFGVHQCLGQNLARLELEVILNALM 373 >3NV6-A nrPDB Length = 452 Score = 29.3 bits (64), Expect = 4.9, Method: Compositional matrix adjust. Identities = 19/59 (32%), Positives = 29/59 (49%), Gaps = 3/59 (5%) Query: 463 FGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPD-PDYSSMVVLPTEPAEIIW 520 FGGG HRC G A +++ I+T + R +K + P Y S +V E ++W Sbjct: 392 FGGGPHRCAGMHLARMEV--IVTLEEWLKRIPEFSFKEGETPIYHSGIVAAVENVPLVW 448 >4JBT-A nrPDB Length = 410 Score = 28.9 bits (63), Expect = 5.3, Method: Compositional matrix adjust. Identities = 45/220 (20%), Positives = 88/220 (40%), Gaps = 56/220 (25%) Query: 267 RGDIDPNRDLIDSLLIHSTYKDG-VKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGE 325 R +P DL S LI++T DG +T++E+ L ++ G T+ S + L Sbjct: 206 RKTAEPGDDLT-SALIYAT--DGETPLTEEEVIGNLQALVAAGHETTVSLILTAVRALLS 262 Query: 326 KPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMP-LHSIFRKVT 384 P E + L+++ ++ +E I+ETLR P +H + R T Sbjct: 263 HP--------EQLRLVRD-----GEIGWE---------TAIEETLRWDGPVIHLLMRFAT 300 Query: 385 NPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDE 444 + + + ++P+G V++S A ++ + +D Sbjct: 301 EDIDL--GDAVIPRGEGVVMS------------------------YRAIGRDITVHGADA 334 Query: 445 VDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTIL 484 D+ +++ ++ ++ FG G H C G A ++ L Sbjct: 335 DDF---DITRATAARHISFGHGPHICPGAALARLEAAIAL 371 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5FSA-A nrPDB 644 0.0 5JLC-A nrPDB 613 e-176 4WMZ-A nrPDB 602 e-172 6CR2-A nrPDB 497 e-141 3JUS-A nrPDB 425 e-119 2WX2-A nrPDB 411 e-115 3L4D-A nrPDB 410 e-114 6AYB-A nrPDB 395 e-110 2X2N-A nrPDB 394 e-110 2W0A-A nrPDB 358 3e-99 5YLW-A nrPDB 299 2e-81 3EL3-A nrPDB 296 2e-80 2VE3-A nrPDB 293 1e-79 3SN5-A nrPDB 292 4e-79 2HI4-A nrPDB 287 7e-78 3TBG-A nrPDB 274 7e-74 2NNH-A nrPDB 271 5e-73 6B82-A nrPDB 268 4e-72 3E6I-A nrPDB 267 1e-71 1N6B-A nrPDB 265 3e-71 4GQS-A nrPDB 263 1e-70 6DWN-A nrPDB 262 2e-70 3B98-A nrPDB 262 4e-70 5W0C-A nrPDB 260 1e-69 4H1N-A nrPDB 260 1e-69 3IBD-A nrPDB 253 1e-67 5E58-A nrPDB 249 2e-66 5E0E-A nrPDB 248 4e-66 2PG7-A nrPDB 244 6e-65 3MDV-A nrPDB 243 1e-64 6DA2-A nrPDB 243 1e-64 5VBU-A nrPDB 241 5e-64 4R20-A nrPDB 241 7e-64 3DL9-A nrPDB 238 5e-63 3QZ1-A nrPDB 237 7e-63 4R1Z-A nrPDB 233 2e-61 5VEU-A nrPDB 230 8e-61 5UYS-A nrPDB 226 2e-59 6C94-A nrPDB 214 7e-56 6IQ5-A nrPDB 211 6e-55 4KPA-A nrPDB 196 2e-50 2IAG-A nrPDB 194 7e-50 3K9V-A nrPDB 191 7e-49 3MZS-A nrPDB 190 1e-48 3N9Z-A nrPDB 184 8e-47 5L94-A nrPDB 173 2e-43 3NC3-A nrPDB 172 4e-43 5XJN-A nrPDB 170 2e-42 2VZM-A nrPDB 169 3e-42 5GWE-A nrPDB 169 3e-42 5OFQ-A nrPDB 159 3e-39 3S79-A nrPDB 158 4e-39 4GGV-A nrPDB 158 7e-39 2WIO-A nrPDB 157 1e-38 6A7J-A nrPDB 146 3e-35 6A7I-A nrPDB 146 3e-35 5Z9I-A nrPDB 143 2e-34 4WPZ-A nrPDB 143 3e-34 1CPT-A nrPDB 141 9e-34 2XKR-A nrPDB 135 4e-32 5FYF-A nrPDB 130 2e-30 6HQW-A nrPDB 130 2e-30 4XE3-A nrPDB 124 1e-28 1WIY-A nrPDB 122 4e-28 Sequences not found previously or not previously below threshold: 4RM4-A nrPDB 156 1e-38 3EJB-B nrPDB 156 2e-38 5VWS-A nrPDB 151 5e-37 5CJE-A nrPDB 146 2e-35 4YT3-A nrPDB 142 4e-34 6GMF-A nrPDB 142 4e-34 5XW2-A nrPDB 141 1e-33 5XNT-A nrPDB 141 1e-33 3R9C-A nrPDB 135 4e-32 6M7X-A nrPDB 133 1e-31 1Z8P-A nrPDB 133 2e-31 6HQG-A nrPDB 132 4e-31 4ZGX-A nrPDB 131 6e-31 6GK6-A nrPDB 131 1e-30 5LIE-A nrPDB 130 2e-30 4TRI-A nrPDB 129 2e-30 1ODO-A nrPDB 129 2e-30 3RWL-A nrPDB 128 7e-30 4YZR-A nrPDB 126 3e-29 4JBT-A nrPDB 125 4e-29 2Y5N-A nrPDB 125 4e-29 3WVS-A nrPDB 125 5e-29 2WM5-A nrPDB 124 8e-29 5EX6-C nrPDB 124 8e-29 4Z5P-A nrPDB 124 9e-29 3A50-A nrPDB 124 1e-28 1GWI-A nrPDB 124 1e-28 5NWS-A nrPDB 123 2e-28 3ABB-A nrPDB 123 2e-28 4UBS-A nrPDB 122 3e-28 3MGX-A nrPDB 121 6e-28 5IT1-A nrPDB 121 7e-28 3TKT-A nrPDB 120 2e-27 6CVC-A nrPDB 120 2e-27 5DQN-A nrPDB 119 3e-27 3ABA-A nrPDB 118 6e-27 6FSH-A nrPDB 118 8e-27 2FR7-A nrPDB 116 2e-26 4TX3-A nrPDB 116 3e-26 5Y1I-A nrPDB 115 4e-26 2Z36-A nrPDB 114 6e-26 1F4U-A nrPDB 114 7e-26 2RFC-A nrPDB 114 8e-26 6GII-A nrPDB 114 9e-26 4PWV-A nrPDB 114 1e-25 1LG9-A nrPDB 114 1e-25 6G5O-A nrPDB 114 1e-25 1EHE-A nrPDB 114 1e-25 1UED-A nrPDB 113 2e-25 4MM0-A nrPDB 113 2e-25 5YSW-A nrPDB 113 2e-25 4OQS-A nrPDB 113 2e-25 3IVY-A nrPDB 113 2e-25 4OQR-A nrPDB 113 2e-25 1Q5D-A nrPDB 111 6e-25 2ZBZ-A nrPDB 111 7e-25 5H1Z-A nrPDB 111 7e-25 5HDI-A nrPDB 111 7e-25 3A1L-A nrPDB 111 9e-25 6DCD-A nrPDB 110 2e-24 1UE8-A nrPDB 110 2e-24 6B11-A nrPDB 109 2e-24 4Z5Q-A nrPDB 109 3e-24 6HQD-A nrPDB 108 7e-24 5LIV-A nrPDB 106 2e-23 2UUQ-A nrPDB 106 3e-23 6F88-A nrPDB 105 4e-23 3WEC-A nrPDB 105 4e-23 6F0B-A nrPDB 105 5e-23 3P3Z-A nrPDB 105 6e-23 5FOI-A nrPDB 104 1e-22 4DO1-A nrPDB 103 2e-22 3TYW-A nrPDB 102 4e-22 2WIY-A nrPDB 101 6e-22 5L1U-A nrPDB 100 3e-21 6FYJ-A nrPDB 100 3e-21 6M7L-A nrPDB 99 5e-21 2ZQJ-A nrPDB 98 9e-21 5DE9-A nrPDB 97 2e-20 5YHJ-A nrPDB 97 2e-20 3BUJ-A nrPDB 96 4e-20 6BLD-A nrPDB 95 5e-20 6G71-A nrPDB 95 7e-20 5OMS-A nrPDB 95 8e-20 2X9P-A nrPDB 95 9e-20 5HH3-A nrPDB 95 1e-19 5KYO-A nrPDB 93 2e-19 3OFT-A nrPDB 92 6e-19 5HIW-A nrPDB 91 1e-18 3AWQ-A nrPDB 90 2e-18 5EX8-A nrPDB 89 4e-18 4FB2-A nrPDB 88 7e-18 3OO3-A nrPDB 85 9e-17 2QBO-A nrPDB 85 1e-16 5M0P-A nrPDB 84 2e-16 3DBM-A nrPDB 82 5e-16 2RCM-A nrPDB 81 1e-15 5D3U-A nrPDB 79 5e-15 4C9K-A nrPDB 79 6e-15 2IJ7-A nrPDB 78 9e-15 2NZA-A nrPDB 76 4e-14 3NV6-A nrPDB 74 1e-13 2YJN-B nrPDB 51 1e-06 5EUV-A nrPDB 32 0.57 5J04-A nrPDB 32 0.81 2CLY-A nrPDB 32 0.85 2NYG-A nrPDB 31 0.95 2ISB-A nrPDB 31 1.1 3UR7-A nrPDB 30 2.6 3IJW-A nrPDB 30 3.0 2D6F-C nrPDB 29 6.5 >5FSA-A nrPDB Length = 490 Score = 644 bits (1662), Expect = 0.0, Method: Composition-based stats. Identities = 478/486 (98%), Positives = 480/486 (98%) Query: 43 LRKDRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHE 102 + K PLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHE Sbjct: 1 MAKKTPPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHE 60 Query: 103 FVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKI 162 FVFNAKLSDVSAE+AYKHLTTPVFG GVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKI Sbjct: 61 FVFNAKLSDVSAEEAYKHLTTPVFGTGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKI 120 Query: 163 REEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYS 222 REEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYS Sbjct: 121 REEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYS 180 Query: 223 DLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLI 282 DLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIK RRERGDIDPNRDLIDSLLI Sbjct: 181 DLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKLRRERGDIDPNRDLIDSLLI 240 Query: 283 HSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLK 342 HSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLK Sbjct: 241 HSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLK 300 Query: 343 EKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYV 402 EKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYV Sbjct: 301 EKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYV 360 Query: 403 LVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLP 462 LVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLP Sbjct: 361 LVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLP 420 Query: 463 FGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIWEK 522 FGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIWEK Sbjct: 421 FGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIWEK 480 Query: 523 RETCMF 528 RETCMF Sbjct: 481 RETCMF 486 >5JLC-A nrPDB Length = 515 Score = 613 bits (1580), Expect = e-176, Method: Composition-based stats. Identities = 332/516 (64%), Positives = 400/516 (77%), Gaps = 9/516 (1%) Query: 11 INYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPLVFYWIPWFGSAASYGQQPYE 70 ++YF +L + Q++SI++ +PFVY + WQ LYSLRKDR PLVFYWIPW GSA YG +PYE Sbjct: 1 LSYFQALPLAQRVSIMVALPFVYTITWQLLYSLRKDRPPLVFYWIPWVGSAIPYGTKPYE 60 Query: 71 FFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGV 130 FFE C++KYGD+FSFMLLG+IMTVYLGPKGHEF+FNAKL+DVSAE AY HLTTPVFGKGV Sbjct: 61 FFEDCQKKYGDIFSFMLLGRIMTVYLGPKGHEFIFNAKLADVSAEAAYSHLTTPVFGKGV 120 Query: 131 IYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMK 190 IYDCPN RLMEQKKF K ALT ++F RYVP I EEI YF ++FK+ E G+ +VM Sbjct: 121 IYDCPNHRLMEQKKFVKGALTKEAFVRYVPLIAEEIYKYFRNSKNFKINENNSGIVDVMV 180 Query: 191 TQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQ 250 +QPE+TIFTASRSL G EMR D FA LYSDLDKGFTPINFVFPNLPL HY +RD AQ Sbjct: 181 SQPEMTIFTASRSLLGKEMRDKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQ 240 Query: 251 KKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQH 310 + IS TYM IK RRE+ DI NRDLID L+ +STYKDG KMTDQEIANLLIG+LMGGQH Sbjct: 241 QAISGTYMSLIKERREKNDIQ-NRDLIDELMKNSTYKDGTKMTDQEIANLLIGVLMGGQH 299 Query: 311 TSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETL 370 TSA+TSAW LLHL E+P +Q+ +YQE + +L D +LTY+DLQ +P +N IKETL Sbjct: 300 TSAATSAWCLLHLAERPDVQEELYQEQMRVLNN---DTKELTYDDLQNMPLLNQMIKETL 356 Query: 371 RMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTA 430 R+H PLHS+FRKV + IP T+Y+VP+ ++VLVSPGY H E +F P +F+ RWD Sbjct: 357 RLHHPLHSLFRKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGD 416 Query: 431 AAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYN 490 AA +++ DEVDYGFG +SKGVSSPYLPFGGGRHRCIGE FAY QLG +++ F+ Sbjct: 417 AASSSAA---GGDEVDYGFGAISKGVSSPYLPFGGGRHRCIGELFAYCQLGVLMSIFIRT 473 Query: 491 LRWTI--DGYKVPDPDYSSMVVLPTEPAEIIWEKRE 524 ++W +G VP D++SMV LPT PA+I WEKR Sbjct: 474 MKWRYPTEGETVPPSDFTSMVTLPTAPAKIYWEKRH 509 >4WMZ-A nrPDB Length = 539 Score = 602 bits (1552), Expect = e-172, Method: Composition-based stats. Identities = 338/522 (64%), Positives = 411/522 (78%), Gaps = 9/522 (1%) Query: 4 VETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYLYSLRKDRAPLVFYWIPWFGSAAS 63 +E V G+++FL+L + Q+IS+++ +PF+YN+VWQ LYSLRKDR PLVFYWIPW GSA Sbjct: 12 LEYVNIGLSHFLALPLAQRISLIIIIPFIYNIVWQLLYSLRKDRPPLVFYWIPWVGSAVV 71 Query: 64 YGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTT 123 YG +PYEFFE C++KYGD+FSF+LLG++MTVYLGPKGHEFVFNAKL+DVSAE AY HLTT Sbjct: 72 YGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTT 131 Query: 124 PVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTH 183 PVFGKGVIYDCPNSRLMEQKKF K ALT ++FK YVP I EE+ YF ++F+L E+T Sbjct: 132 PVFGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYKYFRDSKNFRLNERTT 191 Query: 184 GVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHY 243 G +VM TQPE+TIFTASRSL G EMR D FA LYSDLDKGFTPINFVFPNLPL HY Sbjct: 192 GTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHY 251 Query: 244 WRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIG 303 +RD AQK IS TYM IK RR+ DI +RDLIDSL+ +STYKDGVKMTDQEIANLLIG Sbjct: 252 RKRDHAQKAISGTYMSLIKERRKNNDIQ-DRDLIDSLMKNSTYKDGVKMTDQEIANLLIG 310 Query: 304 ILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVN 363 +LMGGQHTSA+TSAW LLHL E+P +Q +Y+E + +L G +LTY+ LQ++P +N Sbjct: 311 VLMGGQHTSAATSAWILLHLAERPDVQQELYEEQMRVLD---GGKKELTYDLLQEMPLLN 367 Query: 364 NTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFD 423 TIKETLRMH PLHS+FRKV + +P T+Y++P G++VLVSPGY H + YF N F+ Sbjct: 368 QTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFN 427 Query: 424 PTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTI 483 RW+ +A S++ +EVDYGFG +SKGVSSPYLPFGGGRHRCIGE FAY QLG + Sbjct: 428 IHRWNNDSAS----SYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVL 483 Query: 484 LTTFVYNLRWT-IDGYKVPDPDYSSMVVLPTEPAEIIWEKRE 524 ++ F+ L+W +G VP PD++SMV LPT PA+IIWEKR Sbjct: 484 MSIFIRTLKWHYPEGKTVPPPDFTSMVTLPTGPAKIIWEKRN 525 >6CR2-A nrPDB Length = 477 Score = 497 bits (1280), Expect = e-141, Method: Composition-based stats. Identities = 241/484 (49%), Positives = 329/484 (67%), Gaps = 13/484 (2%) Query: 43 LRKDRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHE 102 + K P+VF+W P+ GS SYG PY+FF CR KYGD+F+F+LLGK TVYLG KG++ Sbjct: 1 MAKKTPPVVFHWFPFIGSTISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTVYLGTKGND 60 Query: 103 FVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKI 162 F+ N KL DV AE+ Y LTTPVFG+ V+YDCPN++LMEQKKF K+ LT+D+ + YVP I Sbjct: 61 FILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQKKFVKYGLTSDALRSYVPLI 120 Query: 163 REEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYS 222 +E+ ++ +F+ GV +V KT EITI+TASRSL G E+R FD +FA+LY Sbjct: 121 TDEVESFVKNSPAFQ---GHKGVFDVCKTIAEITIYTASRSLQGKEVRSKFDSTFAELYH 177 Query: 223 DLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLI 282 +LD GF PINF+ P PLPH +RDAAQ+K++ TYM+ IK+RR+ G + D++ +L+ Sbjct: 178 NLDMGFAPINFMLPWAPLPHNRKRDAAQRKLTETYMEIIKARRQAGSKKDSEDMVWNLM- 236 Query: 283 HSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLK 342 YK+G + D+EIA+++I +LM GQH+S+ST++W +L L +P + + +YQE + +L Sbjct: 237 SCVYKNGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVL- 295 Query: 343 EKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYV 402 G DL LTY++LQKL IKETLR+H P+HSI R V NP+ + T+Y++P H V Sbjct: 296 --GSDLPPLTYDNLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSHNV 353 Query: 403 LVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLP 462 L SPG SE +F NP +++P RWD A S ++VDYG+G VSKG +SPYLP Sbjct: 354 LSSPGVTARSEEHFPNPLEWNPHRWDENIA----ASAEDDEKVDYGYGLVSKGTNSPYLP 409 Query: 463 FGGGRHRCIGEQFAYVQLGTILTTFVYNLRWT-IDGYK-VPDPDYSSMVVLPTEPAEIIW 520 FG GRHRCIGEQFAY+QLGTI V R+ + G +PD DYSS+ P + + + Sbjct: 410 FGAGRHRCIGEQFAYLQLGTITAVLVRLFRFRNLPGVDGIPDTDYSSLFSKPLGRSFVEF 469 Query: 521 EKRE 524 EKR Sbjct: 470 EKRH 473 >3JUS-A nrPDB Length = 461 Score = 425 bits (1091), Expect = e-119, Method: Composition-based stats. Identities = 180/481 (37%), Positives = 251/481 (52%), Gaps = 37/481 (7%) Query: 46 DRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVF 105 P +F IP+ G A ++G+ P EF E+ +KYG VFSF ++GK T LG +F Sbjct: 11 KSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLF 70 Query: 106 NAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREE 165 N+K D++AED Y LTTPVFGKGV YD PN +EQKK K L FK++V I +E Sbjct: 71 NSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKE 130 Query: 166 ILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLD 225 YF + G NV + E+ I TAS L G E+R + AQLY+DLD Sbjct: 131 TKEYFES-------WGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLD 183 Query: 226 KGFTPINFVFP-NLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHS 284 GF+ ++ P LPLP + RRD A ++I + K I+ RR+ + D I L+ + Sbjct: 184 GGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKI---DDILQTLLDA 240 Query: 285 TYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEK 344 TYKDG +TD E+A +LIG+L+ GQHTS++TSAW L LQ Y E + E Sbjct: 241 TYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGE- 299 Query: 345 GGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLV 404 +L LTY+ L+ L ++ IKETLR+ P+ + R P + Y +P GH V V Sbjct: 300 --NLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTV--AGYTIPPGHQVCV 355 Query: 405 SPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFG 464 SP + + DF+P R+ + G Y+PFG Sbjct: 356 SPTVNQRLKDSWVERLDFNPDRYLQDNPAS--------------------GEKFAYVPFG 395 Query: 465 GGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIWEKRE 524 GRHRCIGE FAYVQ+ TI +T + + + P +Y++M+ P P I +++R Sbjct: 396 AGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPV-IRYKRRS 454 Query: 525 T 525 T Sbjct: 455 T 455 >2WX2-A nrPDB Length = 473 Score = 411 bits (1056), Expect = e-115, Method: Composition-based stats. Identities = 135/478 (28%), Positives = 228/478 (47%), Gaps = 48/478 (10%) Query: 44 RKDRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKY-GDVFSFMLLGKIMTVYLGPKGHE 102 R P+ +P+ G +G+ P EF + C++ VF+ + G+ +T+ P H Sbjct: 14 RPTDPPVYPVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHS 73 Query: 103 FVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKI 162 F+ + +S + Y + TPVFG+GV Y P R+ EQ F LT F+ +VP I Sbjct: 74 RFFSPRNEILSPREVYT-IMTPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAI 132 Query: 163 REEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFD-RSFAQLY 221 + E+ + + ++ GV N+++ + I TA + LFG+++R+ + R FAQL Sbjct: 133 QHEVRKFMAENW-----KEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLL 187 Query: 222 SDLDKGFTPINFVFPNL---PLPHYWRRDAAQKKISATYMKEIKSR-RERGDIDPNRDLI 277 S ++ P P L PLP R A+ ++ + I +R +E D N + Sbjct: 188 SKMESSLIPAAVFMPWLLRLPLPQSARCREARAELQKILGEIIVAREKEEASKDNNTSDL 247 Query: 278 DSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGE--KPHLQDVIYQ 335 L+ + Y+DG +M+ E+ +++ + GQHTS T++W +LHL D +++ Sbjct: 248 LGGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHK 307 Query: 336 EVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYI 395 E+ E + D + ++P ++E++R PL + R V +++ +Y+ Sbjct: 308 EIDEFPAQLNYDNV------MDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKV--GSYV 359 Query: 396 VPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKG 455 VPKG + SP +H E F NP +DP R + Sbjct: 360 VPKGDIIACSPLLSHHDEEAFPNPRLWDPER--------------------------DEK 393 Query: 456 VSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPT 513 V ++ FG G H+CIG++FA +Q+ TIL T + + +VPDPDY +MVV PT Sbjct: 394 VDGAFIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRDEVPDPDYHTMVVGPT 451 >3L4D-A nrPDB Length = 453 Score = 410 bits (1052), Expect = e-114, Method: Composition-based stats. Identities = 132/473 (27%), Positives = 222/473 (46%), Gaps = 47/473 (9%) Query: 48 APLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNA 107 P+V P+ G +G+ P F ++KYG +F+ + G +TV H F Sbjct: 5 PPVVHGTTPFVGHIIQFGKDPLGFMLKAKKKYGGIFTMNICGNRITVVGDVHQHSKFFTP 64 Query: 108 KLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEIL 167 + +S + Y + PVFG+GV Y P R+ EQ F LT F+ + P I+ E+ Sbjct: 65 RNEILSPREVYSFMV-PVFGEGVAYAAPYPRMREQLNFLAEELTVAKFQNFAPSIQHEVR 123 Query: 168 NYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFD-RSFAQLYSDLDK 226 + + + K G N++ + I TA + LFG+++R+ D R FAQL + ++ Sbjct: 124 KFMKANWN-----KDEGEINILDDCSAMIINTACQCLFGEDLRKRLDARQFAQLLAKMES 178 Query: 227 GFTPINFVFPN---LPLPHYWRRDAAQKKISATYMKEIKSR-RERGDIDPNRDLIDSLLI 282 P P LPLP +R A+ ++ + I +R +E D N + + L+ Sbjct: 179 CLIPAAVFLPWILKLPLPQSYRCRDARAELQDILSEIIIAREKEEAQKDTNTSDLLAGLL 238 Query: 283 HSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLG--EKPHLQDVIYQEVVEL 340 + Y+DG +M+ E+ +++ + GQHTS T+ W LLHL ++QE+ E Sbjct: 239 GAVYRDGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLHQEIDEF 298 Query: 341 LKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGH 400 + D ++++P +E++R PL + RKV P+++ Y+VP+G Sbjct: 299 PAQLNYDNV------MEEMPFAEQCARESIRRDPPLVMLMRKVLKPVQV--GKYVVPEGD 350 Query: 401 YVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPY 460 + SP +H E F NP +++P R K V + Sbjct: 351 IIACSPLLSHQDEEAFPNPREWNPER-------------------------NMKLVDGAF 385 Query: 461 LPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPT 513 FG G H+CIGE+F +Q+ T+L T + + + + G +P+P+Y +MVV PT Sbjct: 386 CGFGAGVHKCIGEKFGLLQVKTVLATVLRDYDFELLG-PLPEPNYHTMVVGPT 437 >6AYB-A nrPDB Length = 466 Score = 395 bits (1015), Expect = e-110, Method: Composition-based stats. Identities = 162/492 (32%), Positives = 254/492 (51%), Gaps = 48/492 (9%) Query: 42 SLRKDRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGH 101 S + P V IP+ GS S+ + P +F +KYGDVF+ +LGK MT PK Sbjct: 6 SSKGKLPPRVPNLIPYVGSFVSFAKNPVQFIIDNSKKYGDVFTATILGKEMTFLNHPKIL 65 Query: 102 EFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPN-SRLMEQKKFAKFALTTDSFKRYVP 160 + F A +++S D Y+ + PVFG GV+YD + R+MEQ KF LTT F+ +V Sbjct: 66 DTFFKATDNELSLRDVYRFM-RPVFGTGVVYDADSTERMMEQVKFVSSGLTTARFRVFVD 124 Query: 161 KIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRR-IFDRSFAQ 219 +EI + G +V + ++ IFTASR L GDE+R+ + +++ + Sbjct: 125 IFEDEIAHKVKEL-------GPEGTVDVAELMADLIIFTASRCLLGDEVRQYLSEKNLGK 177 Query: 220 LYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNR----- 274 LY D+D G +P++F +P+LP P +RD A+K + + + + RRE P R Sbjct: 178 LYHDIDDGISPLSFFYPSLPAP---KRDKARKAVGEIFQELLDKRREEHKKHPERLLDES 234 Query: 275 --DLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDV 332 D++D LL YKDG ++TD +LI L GQHTS+ TS+W L+++ + + Sbjct: 235 KMDVVDHLLT-QKYKDGQELTDVHRIGILIAGLFAGQHTSSITSSWTLMNVISNKKVLEK 293 Query: 333 IYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPET 392 + +E E++ G L Y+ + K+ + +KE LRM+ PL I R P + Sbjct: 294 VRKEQEEIM----GSDKVLDYDKVMKMDYLEACMKEALRMYPPLIMIMRMARKPRECEQ- 348 Query: 393 NYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKV 452 YI+PKG+ ++VSP A + NP+ FDP R + + +G Sbjct: 349 -YIIPKGNILVVSPSVAGRCTDTYTNPDVFDPERLT-----------ERKEHEKFKYGA- 395 Query: 453 SKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLP 512 +PFG GRH+CIGE FA +Q+ +I++ + G K+PDP Y+S+VV P Sbjct: 396 --------VPFGAGRHKCIGENFALLQVKSIISILLRYFDMEYIG-KIPDPSYTSLVVGP 446 Query: 513 TEPAEIIWEKRE 524 + P + ++ R+ Sbjct: 447 SPPTRMRYKLRK 458 >2X2N-A nrPDB Length = 475 Score = 394 bits (1011), Expect = e-110, Method: Composition-based stats. Identities = 127/490 (25%), Positives = 228/490 (46%), Gaps = 49/490 (10%) Query: 44 RKDRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKY-GDVFSFMLLGKIMTVYLGPKGHE 102 R P+ +P G +G+ P F + C+++ +F+ ++GK +T+ P H Sbjct: 14 RPTDPPVYPVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEHS 73 Query: 103 FVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKI 162 F + +S + Y + PVFG+GV Y P R+ EQ F LT F+ +VP I Sbjct: 74 RFFLPRNEVLSPREVYSFMV-PVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAI 132 Query: 163 REEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFD-RSFAQLY 221 + E+ + + +K G N+++ + I TA + LFG+++R+ D R FAQL Sbjct: 133 QHEVRKFMAANW-----DKDEGEINLLEDCSTMIINTACQCLFGEDLRKRLDARRFAQLL 187 Query: 222 SDLDKGFTPINFVFPNLPLP---HYWRRDAAQKKISATYMKEIKSRRERG-DIDPNRDLI 277 + ++ P P L R A+ ++ + I +R+ + D + + Sbjct: 188 AKMESSLIPAAVFLPILLKLPLPQSARCHEARTELQKILSEIIIARKAAAVNKDSSTSDL 247 Query: 278 DSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQ--DVIYQ 335 S L+ + Y+DG M+ E+ +++ + GQHTS+ T+ W +LHL +++ + + + Sbjct: 248 LSGLLSAVYRDGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRK 307 Query: 336 EVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYI 395 E+ E + + + ++P +E++R PL + RKV +++ +Y+ Sbjct: 308 EIEEFPAQLNYNNV------MDEMPFAERCARESIRRDPPLLMLMRKVMADVKV--GSYV 359 Query: 396 VPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKG 455 VPKG + SP +H E F P +DP R + Sbjct: 360 VPKGDIIACSPLLSHHDEEAFPEPRRWDPER--------------------------DEK 393 Query: 456 VSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPT-E 514 V ++ FG G H+CIG++F +Q+ TIL T + + + +VPDPDY +MVV PT Sbjct: 394 VEGAFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQLLRDEVPDPDYHTMVVGPTAS 453 Query: 515 PAEIIWEKRE 524 + + +R+ Sbjct: 454 QCRVKYIRRK 463 >2W0A-A nrPDB Length = 455 Score = 358 bits (918), Expect = 3e-99, Method: Composition-based stats. Identities = 124/478 (25%), Positives = 211/478 (44%), Gaps = 37/478 (7%) Query: 48 APLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNA 107 P V G + P + R + GDV +F L GK + + G +EF F A Sbjct: 6 LPRVSGGHDEHGHLEEFRTDPIGLMQRVRDELGDVGTFQLAGKQVVLLSGSHANEFFFRA 65 Query: 108 KLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEIL 167 D+ AY +T P+FG+ V++D R E A AL + K + I +++ Sbjct: 66 GDDDLDQAKAYPFMT-PIFGEAVVFDASPERRKEMLHNA--ALRGEQMKGHAATIEDQVR 122 Query: 168 NYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKG 227 G +++ E+TI+T+S L G + R D FA+LY +L++G Sbjct: 123 R-------MIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERG 175 Query: 228 FTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDID-PNRDLIDSLLIHSTY 286 P+ +V P LP+ + RRD A+ + A + R D +RD++D L+ Sbjct: 176 TDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAE 235 Query: 287 KDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGG 346 + + EI + I ++ G HTS+ T++W L+ L + E+ EL G Sbjct: 236 TGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDEL----YG 291 Query: 347 DLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSP 406 D +++ L+++P + N +KETLR+H PL + R + + + +G V SP Sbjct: 292 DGRSVSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEV--QGHRIHEGDLVAASP 349 Query: 407 GYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGG 466 ++ F +P DF P R++ + + ++PFG G Sbjct: 350 AISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWT-------------------WIPFGAG 390 Query: 467 RHRCIGEQFAYVQLGTILTTFVYNLRWTI-DGYKVPDPDYSSMVVLPTEPAEIIWEKR 523 RHRC+G FA +Q+ I + + + + + D+S MVV +PA + + +R Sbjct: 391 RHRCVGAAFAIMQIKAIFSVLLREYEFEMAQPPESYRNDHSKMVVQLAQPAAVRYRRR 448 >5YLW-A nrPDB Length = 495 Score = 299 bits (766), Expect = 2e-81, Method: Composition-based stats. Identities = 99/511 (19%), Positives = 181/511 (35%), Gaps = 71/511 (13%) Query: 26 LLGVPFVYNLVWQYLYSLRKDRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSF 85 LL F +L R+ P + P G+ G P++ F ++YG + S Sbjct: 6 LLAALFFIAATITFLSFRRRRNLPPGPFPYPIVGNMLQLGANPHQVFAKLSKRYGPLMSI 65 Query: 86 MLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVF-GKGV---IYDCPNSR--- 138 L + P +++ E ++H VF G+ + ++ C + + Sbjct: 66 HLGSLYTVIVSSP------------EMAKEILHRH--GQVFSGRTIAQAVHACDHDKISM 111 Query: 139 --------LMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMK 190 + +K K + ++ +R + L + D K + V ++ + Sbjct: 112 GFLPVASEWRDMRKICKEQMFSNQSMEASQGLRRQKLQQLL-DHVQKCSDSGRAV-DIRE 169 Query: 191 TQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVF----------PNLPL 240 T+ S +LF + FD + ++ +G I V P P Sbjct: 170 AAFITTLNLMSATLFSSQATE-FDSKATMEFKEIIEGVATIVGVPNFADYFPILRPFDPQ 228 Query: 241 PHYWRRDAAQKKISATYMKEIKSRRERGDIDPN---RDLIDSLLIHSTYKDGVKMTDQEI 297 R D K+ A + R E +PN +D +++ + K+ Sbjct: 229 GVKRRADVFFGKLLAKIEGYLNERLESKRANPNAPKKDDFLEIVVDIIQANEFKLKTHHF 288 Query: 298 ANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQ 357 +L++ + +GG T+ ++ W + L P + E+ + GD + + Sbjct: 289 THLMLDLFVGGSDTNTTSIEWAMSELVMNPDKMARLKAELKSV----AGDEKIVDESAMP 344 Query: 358 KLPSVNNTIKETLRMHMP-LHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYF 416 KLP + IKE +R+H P + RK + + Y++PKG +L++ + Sbjct: 345 KLPYLQAVIKEVMRIHPPGPLLLPRKAESDQEV--NGYLIPKGTQILINAYAIGRDPSIW 402 Query: 417 DNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFA 476 +PE FDP R+ KG LPFG GR C G A Sbjct: 403 TDPETFDPERFLDNKID-------------------FKGQDYELLPFGSGRRVCPGMPLA 443 Query: 477 YVQLGTILTTFVYNLRWTIDGYKVPDPDYSS 507 L T V+N W ++ D++ Sbjct: 444 TRILHMATATLVHNFDWKLEDDSTAAADHAG 474 >3EL3-A nrPDB Length = 467 Score = 296 bits (757), Expect = 2e-80, Method: Composition-based stats. Identities = 97/457 (21%), Positives = 166/457 (36%), Gaps = 52/457 (11%) Query: 46 DRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVF 105 P+ +P G + P F R +GDV + + LGPK V Sbjct: 22 REPPVAGGGVPLLGHGWRLARDPLAFMSQLRD-HGDV---------VRIKLGPKTVYAVT 71 Query: 106 NAKLSDVSAEDAYKHLTTPVF-------GKGVIYDCPNSRLMEQKKFAKFALTTDSFKRY 158 N +L+ A + H+ P++ GK + Q++ + A D+ Y Sbjct: 72 NPELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAY 131 Query: 159 VPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFA 218 P + EE E ++ + + + + R + DE + A Sbjct: 132 GPIMEEEA---HALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALA 188 Query: 219 QLYSDL-DKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLI 277 ++ + + P+ ++ LPLP R + A + + I RR G DL+ Sbjct: 189 TVFRGMYRRMVVPLGPLY-RLPLPANRRFNDALADLHLLVDEIIAERRASGQK--PDDLL 245 Query: 278 DSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEV 337 +LL + +G + +QEI + ++ IL G T AST W L L + P D I EV Sbjct: 246 TALL-EAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEV 304 Query: 338 VELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVP 397 + + +ED++KL N I E +R+ + + R+ + Y +P Sbjct: 305 EAVTG-----GRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESEL--GGYRIP 357 Query: 398 KGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVS 457 G ++ SP + +D+ +FDP RW A Sbjct: 358 AGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMK---------------- 401 Query: 458 SPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWT 494 PF G+ +C + F+ QL I R+ Sbjct: 402 ----PFSAGKRKCPSDHFSMAQLTLITAALATKYRFE 434 >2VE3-A nrPDB Length = 444 Score = 293 bits (750), Expect = 1e-79, Method: Composition-based stats. Identities = 94/469 (20%), Positives = 189/469 (40%), Gaps = 52/469 (11%) Query: 49 PLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAK 108 P + +PW G ++ +F + +Q++G +F L GK + G + F+F + Sbjct: 14 PPGDFGLPWLGETLNFLND-GDFGKKRQQQFGPIFKTRLFGKNVIFISGALANRFLFTKE 72 Query: 109 LSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILN 168 A + T + G + ++K A + Y+PK+ + Sbjct: 73 QETFQA--TWPLSTRILLGPNALATQMGEIHRSRRKILYQAFLPRTLDSYLPKMDGIVQG 130 Query: 169 YFVTDESFKLKEKTHGVANVMKTQPEI--TIFTASRSLFGDEMRRIFDRSFAQLYSDLDK 226 Y + G AN + P++ F + +LF E + F + + Sbjct: 131 YL----------EQWGKANEVIWYPQLRRMTFDVAATLFMGEKVSQNPQLFPWFETYIQG 180 Query: 227 GFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTY 286 F+ + LP + + A+ + A K IK+R+++ P+ + +L+ + Sbjct: 181 LFS----LPIPLPNTLFGKSQRARALLLAELEKIIKARQQQ---PPSEEDALGILLAARD 233 Query: 287 KDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGG 346 + ++ E+ + ++ +L G T S + F L LG+ +++ + QE +L + Sbjct: 234 DNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQEQNKLQLSQ-- 291 Query: 347 DLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSP 406 +LT E L+K+P ++ ++E LR+ P+ FR++ + + PKG V Sbjct: 292 ---ELTAETLKKMPYLDQVLQEVLRLIPPVGGGFRELIQDCQF--QGFHFPKGWLVSYQI 346 Query: 407 GYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGG 466 H + +PE FDP R+ + ++ F ++PFGGG Sbjct: 347 SQTHADPDLYPDPEKFDPERFTPDGSATHNPPF-------------------AHVPFGGG 387 Query: 467 RHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEP 515 C+G++FA +++ T + WT+ +P + +V P Sbjct: 388 LRECLGKEFARLEMKLFATRLIQQFDWTL----LPGQNLELVVTPSPRP 432 >3SN5-A nrPDB Length = 491 Score = 292 bits (746), Expect = 4e-79, Method: Composition-based stats. Identities = 102/499 (20%), Positives = 189/499 (37%), Gaps = 56/499 (11%) Query: 41 YSLRK--DRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGP 98 S R+ PL IP+ G A +G P EF + ++K+G VF+ L+GK + P Sbjct: 6 SSRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNP 65 Query: 99 KG-HEFVFNAKLSD------VSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALT 151 H+ + + K D + A+ H + + ++ + + A +LT Sbjct: 66 LSYHKVLCHGKYFDWKKFHFALSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLT 125 Query: 152 TDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRR 211 + + I+ V+ S T G+ + + ++FG ++ R Sbjct: 126 ESMMENL-----QRIMRPPVSSNSKTAAWVTEGMYSFCY---RVMFEAGYLTIFGRDLTR 177 Query: 212 IFDRSFAQLYSDLDKGFTPINFVFP----NLPLPHYWRRDAAQKKISATYMKEIKSRRER 267 D A + ++LD F + VFP LP+ + A++K++ + E +RE Sbjct: 178 R-DTQKAHILNNLD-NFKQFDKVFPALVAGLPIHMFRTAHNAREKLAESLRHENLQKRES 235 Query: 268 -GDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEK 326 ++ R ++ L D E A + +L Q + + W L + Sbjct: 236 ISELISLRMFLNDTL--------STFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRN 287 Query: 327 PHLQDVIYQEVVELLKEKG------GDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIF 380 P +EV L+ G G+ L+ +L LP +++ IKE+LR+ +I Sbjct: 288 PEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI- 346 Query: 381 RKVTNP--LRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVS 438 R L + + +Y + K + + P H + +P F R+ K + Sbjct: 347 RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTF 406 Query: 439 FNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTI--D 496 + + ++ Y Y+PFG G C G FA ++ L + + Sbjct: 407 YCNGLKLKYY-----------YMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEG 455 Query: 497 GYKVP--DPDYSSMVVLPT 513 K P D + + +LP Sbjct: 456 QAKCPPLDQSRAGLGILPP 474 >2HI4-A nrPDB Length = 495 Score = 287 bits (734), Expect = 7e-78, Method: Composition-based stats. Identities = 103/522 (19%), Positives = 179/522 (34%), Gaps = 76/522 (14%) Query: 40 LYSLRKDRA-----PLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTV 94 L LR P + P G + G+ P+ Q+YGDV + + V Sbjct: 4 LKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLV 63 Query: 95 YL--------------GPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLM 140 KG ++ + L + + PV+ R + Sbjct: 64 LSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAA--------RRRL 115 Query: 141 EQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHG-------------VAN 187 Q F++ +D + E + S +L+E G VAN Sbjct: 116 AQNALNTFSIASDPASSSSCYLEEHVSKEAKALIS-RLQELMAGPGHFDPYNQVVVSVAN 174 Query: 188 VMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFV--FPNLPLPHYWR 245 V+ F S DEM + + + P++F LP P R Sbjct: 175 VIGAMCFGQHFPES----SDEMLSLVKN--THEFVETASSGNPLDFFPILRYLPNPALQR 228 Query: 246 RDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTY---KDGVKMTDQEIANLLI 302 A ++ K ++ + D + RD+ +L HS G + ++I NL+ Sbjct: 229 FKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVN 288 Query: 303 GILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSV 362 I G T + +W L++L KP +Q I +E+ ++ G D +LP + Sbjct: 289 DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVI----GRERRPRLSDRPQLPYL 344 Query: 363 NNTIKETLRMHMPLH-SIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPED 421 I ET R L +I T + + +PK V V+ + +++P + Sbjct: 345 EAFILETFRHSSFLPFTIPHSTTRDTTL--NGFYIPKKCCVFVNQWQVNHDPELWEDPSE 402 Query: 422 FDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLG 481 F P R+ TA ++K +S + FG G+ RCIGE A ++ Sbjct: 403 FRPERFLTADGT-----------------AINKPLSEKMMLFGMGKRRCIGEVLAKWEIF 445 Query: 482 TILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIWEKR 523 L + L +++ D + + E + +R Sbjct: 446 LFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARR 487 >3TBG-A nrPDB Length = 479 Score = 274 bits (700), Expect = 7e-74, Method: Composition-based stats. Identities = 96/489 (19%), Positives = 171/489 (34%), Gaps = 65/489 (13%) Query: 62 ASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHL 121 + PY F+ R+++GDVFS L + V G V A ++ ED Sbjct: 27 VDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVL---NGLAAVREALVT--HGEDTADRP 80 Query: 122 TTPV-----FG---KGVIYDCPNSRLMEQKKF-----AKFALTTDSFKRYVPKIREEILN 168 P+ FG +GV EQ++F L S +++V + + Sbjct: 81 PVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCA 140 Query: 169 YFVTDESFKLKEK---THGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLD 225 F + V+NV I T R D+ R + AQ + Sbjct: 141 AFANHSGRPFRPNGLLDKAVSNV------IASLTCGRRFEYDDPRFLRLLDLAQEGLKEE 194 Query: 226 KGFTP--INFVFPNLPLPHYWRRDAAQKKISATYMKEI--KSRRERGDIDPNRDLIDSLL 281 GF +N V L +P + +K T + E+ + R P RDL ++ L Sbjct: 195 SGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFL 254 Query: 282 IHSTYKDGVK---MTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVV 338 G D+ + ++ + G T+++T AW LL + P +Q + QE+ Sbjct: 255 AEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEID 314 Query: 339 ELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLH-SIFRKVTNPLRIPETNYIVP 397 +++ G + D +P I E R + + + + + + +P Sbjct: 315 DVI----GQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEV--QGFRIP 368 Query: 398 KGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVS 457 KG ++ + E ++ P F P + A Sbjct: 369 KGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHF--------------------VKP 408 Query: 458 SPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLP--TEP 515 +LPF GR C+GE A ++L T+ + + +++ + P P + + P Sbjct: 409 EAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQ-PRPSHHGVFAFLVSPSP 467 Query: 516 AEIIWEKRE 524 E+ R Sbjct: 468 YELCAVPRH 476 >2NNH-A nrPDB Length = 476 Score = 271 bits (693), Expect = 5e-73, Method: Composition-based stats. Identities = 88/502 (17%), Positives = 175/502 (34%), Gaps = 66/502 (13%) Query: 45 KDRAPLVFYWIPWFGSAASYG-QQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEF 103 K + P +P G+ + + F + + YG VF+ + V+ G + + Sbjct: 8 KGKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKE 67 Query: 104 VFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKF-----AKFALTTDSFKRY 158 + S G G+I R E ++F F + S + Sbjct: 68 ALIDNGEEFSGRGNSPISQRITKGLGIISS-NGKRWKEIRRFSLTTLRNFGMGKRSIEDR 126 Query: 159 VPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIF----D 214 V + ++ ++ P + A ++ + + D Sbjct: 127 VQEEAHCLVEELRKTKASPCD-------------PTFILGCAPCNVICSVVFQKRFDYKD 173 Query: 215 RSFAQLYSDLDKGFT----PINFVFPNLPL-----PHYWRRDAAQKKISATY-MKEIKSR 264 ++F L ++ F P V N PL P + ++ +Y +++K Sbjct: 174 QNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEH 233 Query: 265 RERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLL---IGILMGGQHTSASTSAWFLL 321 + D++ RD ID LI + + ++ I NL+ + + G T+++T + LL Sbjct: 234 QASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLL 293 Query: 322 HLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLH-SIF 380 L + P + + +E+ ++ G +D +P + + E R + + Sbjct: 294 LLLKHPEVTAKVQEEIDHVI----GRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVP 349 Query: 381 RKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFN 440 VT + NY++PKG ++ ++ F NP FDP + Sbjct: 350 HAVTTDTKF--RNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKK---- 403 Query: 441 SSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRW-TIDGYK 499 S ++PF G+ C GE A ++L LTT + N ++D K Sbjct: 404 ----------------SDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLK 447 Query: 500 -VPDPDYSSMVVLPTEPAEIIW 520 + + +V +I + Sbjct: 448 NLNTTAVTKGIVSLPPSYQICF 469 >6B82-A nrPDB Length = 509 Score = 268 bits (685), Expect = 4e-72, Method: Composition-based stats. Identities = 102/500 (20%), Positives = 182/500 (36%), Gaps = 52/500 (10%) Query: 46 DRAPLVFYWIPWFGSAASYGQQ--PYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEF 103 +R+P +P GS S P+ FF+ ++KYGD++S M+ + + + Sbjct: 22 NRSPPSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNNHHHAKE 81 Query: 104 VFNAKLSDVSAEDAYKHLTTPVF---GKGVIYDCPNSRLMEQKKFAKFAL-----TTDSF 155 + K + + +TT + GK + + +S +K AL + S Sbjct: 82 ILIKKGKIFAGRP--RTVTTDLLTRDGKDIAFADYSSTWKFHRKMVHGALCMFGEGSVSI 139 Query: 156 KRYVPKIRE---EILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRI 212 ++ + + E+L E T V NV+ + + + F + M + Sbjct: 140 EKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSSYKRGDAEF-ESMLQY 198 Query: 213 FDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDP 272 + D P +FPN L + + + K+ K+ + + + Sbjct: 199 SQGIVDTVAKDSLVDIFPWLQIFPNKDLRILRQCISIRDKL---LQKKYEEHKVTYSDNV 255 Query: 273 NRDLIDSLLIHSTYKDGVK-------MTDQEIANLLIGILMGGQHTSASTSAWFLLHLGE 325 RDL+D+LL + +T+ + + I G T+ +T W + +L Sbjct: 256 QRDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGAGVETTTTTLKWSIAYLVH 315 Query: 326 KPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSI-FRKVT 384 P +Q I +E+ K G D LP + TI E +R+ + Sbjct: 316 NPQVQRKIQEELD----SKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSPLLIPHVAL 371 Query: 385 NPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDE 444 + Y V KG V+++ H E+ + NPE FDP R+ Sbjct: 372 QDSSV--GEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCP------ 423 Query: 445 VDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTID-GYKVPDP 503 S YLPFG G C+GE A ++L L + + G +PD Sbjct: 424 ------------SGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDL 471 Query: 504 DYSSMVVLPTEPAEIIWEKR 523 VVL + +++ + R Sbjct: 472 QGKFGVVLQPKKFKVVAKVR 491 >3E6I-A nrPDB Length = 476 Score = 267 bits (681), Expect = 1e-71, Method: Composition-based stats. Identities = 97/512 (18%), Positives = 186/512 (36%), Gaps = 79/512 (15%) Query: 45 KDRAPLVFYWIPWFGSAASY-GQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKG-HE 102 K + P + +P G+ + + F Q++G VF+ + + M V G K E Sbjct: 8 KGKLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKE 67 Query: 103 FVFNAKLS-----DVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKR 157 + + K D+ A A++ +G+I++ + K +F+LTT + Sbjct: 68 ALLDYKDEFSGRGDLPAFHAHR-------DRGIIFNNGPT----WKDIRRFSLTT--LRN 114 Query: 158 YVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQ-----PEITIFTASRSLFGDEMRRI 212 Y + +ES +E + + KTQ P I A ++ D + R Sbjct: 115 YGMGKQ--------GNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRK 166 Query: 213 ----FDRSFAQLYSDLDKGF----TPINFVFPNLP-----LPHYWRRDAAQ-KKISATYM 258 D F +L ++ F TP ++ N P LP R+ ++ Sbjct: 167 HFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVS 226 Query: 259 KEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVK---MTDQEIANLLIGILMGGQHTSAST 315 + +K + D + RDL D LL+ + T I + + G T+++T Sbjct: 227 ERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTT 286 Query: 316 SAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMP 375 + LL L + P +++ +++E+ ++ G +D Q++P ++ + E R Sbjct: 287 LRYGLLILMKYPEIEEKLHEEIDRVI----GPSRIPAIKDRQEMPYMDAVVHEIQRFITL 342 Query: 376 LHS-IFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKA 434 + S + + T Y++PKG V+ + + F +PE F P + K Sbjct: 343 VPSNLPHEATRDTIF--RGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKF 400 Query: 435 NSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRW- 493 S + PF G+ C GE A ++L +L + + Sbjct: 401 KY--------------------SDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLK 440 Query: 494 -TIDGYKVPDPDYSSMVVLPTEPAEIIWEKRE 524 +D + ++ R Sbjct: 441 PLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS 472 >1N6B-A nrPDB Length = 473 Score = 265 bits (677), Expect = 3e-71, Method: Composition-based stats. Identities = 89/496 (17%), Positives = 172/496 (34%), Gaps = 57/496 (11%) Query: 45 KDRAPLVFYWIPWFGSAASY-GQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEF 103 K + P P G+ + + + YG VF+ L K V G + + Sbjct: 8 KGKLPPGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLHGYEAVKE 67 Query: 104 VFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSF--KRYVPK 161 + + + L G G+ + + E ++F+ L + + Sbjct: 68 ALVDLGEEFAGRGSVPILEKVSKGLGIAFSNAKT-WKEMRRFSLMTLRNFGMGKRSIEDR 126 Query: 162 IREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLF-GDEMRRIFD---RSF 217 I+EE P + A ++ FD F Sbjct: 127 IQEEARCLVEELRKTNASPCD----------PTFILGCAPCNVICSVIFHNRFDYKDEEF 176 Query: 218 AQLYSDLDKGF----TPINFVFPNLPL-----PHYWRRDAAQKK-ISATYMKEIKSRRER 267 +L L + TP V+ N P P + I M+++K ++ Sbjct: 177 LKLMESLHENVELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKL 236 Query: 268 GDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKP 327 D++ RD ID LI ++ ++ T + + + + G T+++T + LL L + P Sbjct: 237 LDVNNPRDFIDCFLIKMEQENNLEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHP 296 Query: 328 HLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHS-IFRKVTNP 386 + + +E+ ++ G +D ++P + I E R L + + VT Sbjct: 297 EVAARVQEEIERVI----GRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRD 352 Query: 387 LRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVD 446 +R NY +PKG ++ S E+ F NP+ FDP + + Sbjct: 353 VRF--RNYFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKK---------- 400 Query: 447 YGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRW--TIDGYKVPDPD 504 S ++PF G+ C+GE A ++L LT+ + N + ++ + Sbjct: 401 ----------SDYFMPFSAGKRMCVGEGLARMELFLFLTSILQNFKLQSLVEPKDLDITA 450 Query: 505 YSSMVVLPTEPAEIIW 520 + V ++ + Sbjct: 451 VVNGFVSVPPSYQLCF 466 >4GQS-A nrPDB Length = 477 Score = 263 bits (672), Expect = 1e-70, Method: Composition-based stats. Identities = 88/471 (18%), Positives = 168/471 (35%), Gaps = 58/471 (12%) Query: 45 KDRAPLVFYWIPWFGSAASYG-QQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEF 103 + + P +P G+ + + + + YG VF+ + M V G + + Sbjct: 9 RGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKE 68 Query: 104 VFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSF--KRYVPK 161 + S + G G+++ R E ++F+ L + + Sbjct: 69 ALIDLGEEFSGRGHFPLAERANRGFGIVFS-NGKRWKEIRRFSLMTLRNFGMGKRSIEDR 127 Query: 162 IREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIF----DRSF 217 ++EE K P + A ++ + + D+ F Sbjct: 128 VQEEARCLVEELRKTKASPCD----------PTFILGCAPCNVICSIIFQKRFDYKDQQF 177 Query: 218 AQLYSDLDKGF----TPINFVFPNLP-----LPHYWRRDAAQ-KKISATYMKEIKSRRER 267 L L++ TP + N P P + + + ++++K +E Sbjct: 178 LNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQES 237 Query: 268 GDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLI---GILMGGQHTSASTSAWFLLHLG 324 DI+ RD ID LI + + ++ I NL+I +L G T+++T + LL L Sbjct: 238 MDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLL 297 Query: 325 EKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRM-HMPLHSIFRKV 383 + P + + +E+ ++ G +D +P + + E R + S+ V Sbjct: 298 KHPEVTAKVQEEIERVV----GRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAV 353 Query: 384 TNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSD 443 T ++ NY++PKG +L S + F NPE FDP + Sbjct: 354 TCDVKF--RNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKK------- 404 Query: 444 EVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWT 494 S+ ++PF G+ C+GE A ++L LT + N Sbjct: 405 -------------SNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLK 442 >6DWN-A nrPDB Length = 491 Score = 262 bits (670), Expect = 2e-70, Method: Composition-based stats. Identities = 88/476 (18%), Positives = 168/476 (35%), Gaps = 60/476 (12%) Query: 49 PLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLG---------PK 99 P + P G + G+ P+ Q+YGDV + + V G + Sbjct: 13 PPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQ 72 Query: 100 GHEF-----VFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDS 154 G +F ++ L ++ + PV+ R + Q F++ +D Sbjct: 73 GDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAA--------RRRLAQNGLKSFSIASDP 124 Query: 155 FKRYVPKIREEILNYFVTDESFKLK-EKTHGVANVMKTQPEITIFTASRSLFGDEM---- 209 + E + S + G N + FG Sbjct: 125 ASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNH 184 Query: 210 -RRIFDRSFAQLYSDLDKGFTPINFV--FPNLPLPHYWRRDAAQKKISATYMKEIKSRRE 266 + + + ++ P +F+ LP P +K + K +K + Sbjct: 185 QELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYK 244 Query: 267 RGDIDPNRDLIDSLLIHSTYKD-----GVKMTDQEIANLLIGILMGGQHTSASTSAWFLL 321 + RD+ DSL+ H K V+++D++I N+++ + G T + +W L+ Sbjct: 245 TFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLM 304 Query: 322 HLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLH-SIF 380 +L P +Q I +E+ ++ G D LP + I ET R + +I Sbjct: 305 YLVMNPRVQRKIQEELDTVI----GRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIP 360 Query: 381 RKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFN 440 T + + +PKG V V+ + ++ + NP +F P R+ T Sbjct: 361 HSTTRDTSL--KGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPD--------- 409 Query: 441 SSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTID 496 G + K +S + FG G+ +CIGE A ++ L + + +++ Sbjct: 410 ---------GAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVP 456 >3B98-A nrPDB Length = 475 Score = 262 bits (668), Expect = 4e-70, Method: Composition-based stats. Identities = 104/498 (20%), Positives = 178/498 (35%), Gaps = 57/498 (11%) Query: 42 SLRKDRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGH 101 + R++ PL IPW G A +G+ +F ++K+GD+F+ G +TV L Sbjct: 14 TRRRNEPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYITVLLDSN-- 71 Query: 102 EFVFNAKLSDVSAEDAYKH---LTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRY 158 ++A LSDV++ D + L +F + P S +KK A+ S + Sbjct: 72 --CYDAVLSDVASLDQTSYAQVLMKRIFNMILPSHNPES----EKKRAEMHFQGASLTQL 125 Query: 159 VPKIREEILNYFVTDES--FKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRS 216 ++ + E + K G+ N+ + + T ++FG E + Sbjct: 126 SNSMQNNLRLLMTPSEMGLKTSEWKKDGLFNLCYS---LLFKTGYLTVFGAENNN--SAA 180 Query: 217 FAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERG-DIDPNRD 275 Q+Y + F + + P L + + SA K K G D P Sbjct: 181 LTQIYEE----FRRFDKLLPKLARTTVNKEEKQIA--SAAREKLWKWLTPSGLDRKPREQ 234 Query: 276 LIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQ 335 + +G+ Q A LL L Q + + W + +L P + + Sbjct: 235 SWLGSYVKQLQDEGIDAEMQRRAMLLQ--LWVTQGNAGPAAFWVMGYLLTHPEALRAVRE 292 Query: 336 EVVELLKEKGGDLNDLTYEDLQK-LPSVNNTIKETLRMHMPLHSIFRKVTNPLRIP---E 391 E+ L E+ QK P ++ + ETLR+ I R VT +I Sbjct: 293 EIQ--------GGKHLRLEERQKNTPVFDSVLWETLRL-TAAALITRDVTQDKKICLSNG 343 Query: 392 TNYIVPKGHYVLVSPGYA-HTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFG 450 Y + +G + V P + + PE F R+ A F + V Y Sbjct: 344 QEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKKDFFKNGARVKY--- 400 Query: 451 KVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTI----DGYKVPDPD-Y 505 P +P+G + C G FA + ++ T + + + DP Y Sbjct: 401 --------PSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRY 452 Query: 506 SSMVVLPTEPAEIIWEKR 523 ++ P EI + R Sbjct: 453 GFGILQPAGDLEIRYRIR 470 >5W0C-A nrPDB Length = 477 Score = 260 bits (664), Expect = 1e-69, Method: Composition-based stats. Identities = 82/471 (17%), Positives = 167/471 (35%), Gaps = 58/471 (12%) Query: 45 KDRAPLVFYWIPWFGSAASYG-QQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEF 103 + + P +P G+ G + + + + YG VF+ K + V G + + Sbjct: 9 RGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKE 68 Query: 104 VFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSF--KRYVPK 161 + S + G G+++ + E ++F+ L + + Sbjct: 69 ALIDLGEEFSGRGIFPLAERANRGFGIVFS-NGKKWKEIRRFSLMTLRNFGMGKRSIEDR 127 Query: 162 IREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIF----DRSF 217 ++EE K P + A ++ + D+ F Sbjct: 128 VQEEARCLVEELRKTKASPCD----------PTFILGCAPCNVICSIIFHKRFDYKDQQF 177 Query: 218 AQLYSDLDKGF----TPINFVFPNL-PL----PHYWRRDAAQKKISATY-MKEIKSRRER 267 L L++ +P + N P+ P + +Y ++++K +E Sbjct: 178 LNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQES 237 Query: 268 GDIDPNRDLIDSLLIHSTYKDGVK---MTDQEIANLLIGILMGGQHTSASTSAWFLLHLG 324 D++ +D ID L+ + + T + + N + + G T+++T + LL L Sbjct: 238 MDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLL 297 Query: 325 EKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLH-SIFRKV 383 + P + + +E+ ++ G +D +P + + E R L S+ V Sbjct: 298 KHPEVTAKVQEEIERVI----GRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAV 353 Query: 384 TNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSD 443 T ++ NY++PKG +L+S + F NPE FDP + + Sbjct: 354 TCDIKF--RNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKY---- 407 Query: 444 EVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWT 494 ++PF G+ C+GE A ++L LT+ + N Sbjct: 408 ----------------FMPFSAGKRICVGEALAGMELFLFLTSILQNFNLK 442 >4H1N-A nrPDB Length = 479 Score = 260 bits (663), Expect = 1e-69, Method: Composition-based stats. Identities = 94/501 (18%), Positives = 176/501 (35%), Gaps = 58/501 (11%) Query: 45 KDRAPLVFYWIPWFGSAASY-GQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEF 103 K + P +P G+ + F R+KYGDVF+ L + + V G + Sbjct: 8 KGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLCGT---DA 64 Query: 104 VFNAKLSDVSAEDAYKHLTT--PVF-GKGVIYDCPNSRLMEQKKFAKFALTTDSF--KRY 158 + A + A + P+F G GVI+ R ++F+ + + Sbjct: 65 IREALVDQAEAFSGRGKIAVVDPIFQGYGVIFA-NGERWRALRRFSLATMRDFGMGKRSV 123 Query: 159 VPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDE---------- 208 +I+EE +L++ + + IT +FG Sbjct: 124 EERIQEEARCLVE-----ELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLR 178 Query: 209 MRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERG 268 + +F +SF+ + S + F + P H Q +I+ + ++ R Sbjct: 179 LLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQ-EINTFIGQSVEKHRATL 237 Query: 269 DIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIG---ILMGGQHTSASTSAWFLLHLGE 325 D RD ID L+ ++ NL++ + G T+++T + L + + Sbjct: 238 DPSNPRDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLK 297 Query: 326 KPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLH-SIFRKVT 384 PH+ + + +E+ +++ G +D K+P + I E R+ + + VT Sbjct: 298 YPHVTERVQKEIEQVI----GSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVT 353 Query: 385 NPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDE 444 + Y++PK V A RYF+ P F+P + A Sbjct: 354 KDTQF--RGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKR-------- 403 Query: 445 VDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWT--IDGYKVPD 502 + ++PF G+ C+GE A +L TT + N + + Sbjct: 404 ------------NEGFMPFSLGKRICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDL 451 Query: 503 PDYSSMVVLPTEPAEIIWEKR 523 S V +I + R Sbjct: 452 TPRESGVGNVPPSYQIRFLAR 472 >3IBD-A nrPDB Length = 476 Score = 253 bits (646), Expect = 1e-67, Method: Composition-based stats. Identities = 95/474 (20%), Positives = 173/474 (36%), Gaps = 51/474 (10%) Query: 69 YEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTT--PVF 126 + F R+KYGDVF+ L + + + G E + A + A + P F Sbjct: 33 LKSFLRFREKYGDVFTVHLGPRPVVMLCG---VEAIREALVDKAEAFSGRGKIAMVDPFF 89 Query: 127 -GKGVIYDCPNSRLMEQKKF-----AKFALTTDSFKRYVPKIREEILNYFVTDESFKLKE 180 G GVI+ N R ++F F + S + + + + ++ + + Sbjct: 90 RGYGVIFANGN-RWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDP 148 Query: 181 KTHGVANVMKTQPEITIFTASRSLFGDE----MRRIFDRSFAQLYSDLDKGFTPINFVFP 236 + + +I R + D+ M +F ++F+ + S + F + Sbjct: 149 TF--LFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLK 206 Query: 237 NLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQE 296 + P H Q +I+A ++ RE D RDLID+ L+H + ++ Sbjct: 207 HFPGAHRQVYKNLQ-EINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSNAHSEFS 265 Query: 297 IANL---LIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTY 353 NL + + G T+++T + L + + PH+ + +Y+E+ +++ G Sbjct: 266 HQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVI----GPHRPPEL 321 Query: 354 EDLQKLPSVNNTIKETLRMHMPLHS-IFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTS 412 D K+P I E R L + VT YI+PK V + A Sbjct: 322 HDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSF--RGYIIPKDTEVFLILSTALHD 379 Query: 413 ERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIG 472 YF+ P+ F+P + A + ++PF G+ C+G Sbjct: 380 PHYFEKPDAFNPDHFLDANGALKK--------------------TEAFIPFSLGKRICLG 419 Query: 473 EQFAYVQLGTILTTFVYNLRW-TIDGYKVPDPDYSSMVVLPTEP-AEIIWEKRE 524 E A +L TT + N + + D V P +I + R Sbjct: 420 EGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPRH 473 >5E58-A nrPDB Length = 493 Score = 249 bits (635), Expect = 2e-66, Method: Composition-based stats. Identities = 88/441 (19%), Positives = 159/441 (36%), Gaps = 53/441 (12%) Query: 72 FESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLT--TPVFGKG 129 F R+KYGDVF+ L + + + G E + A + A + PV G Sbjct: 55 FMRIREKYGDVFTVHLGPRPVVMLYGT---EAIREALVDQAEAFSGRGTIAVIKPVIGDY 111 Query: 130 VIYDCPNSRLMEQKKFAKFALTTDSF--KRYVPKIREEILNYFVTDESFKLKEKTHGVAN 187 + R ++F+ + + +I+EE +L++ + Sbjct: 112 GMIFSNGERWKVLRRFSLATMRDFGMGKRSVEDRIQEEAQCLVE-----ELQKSQGAPLD 166 Query: 188 VMKTQPEITIFTASRSLFGDE----------MRRIFDRSFAQLYSDLDKGFTPINFVFPN 237 IT +FG+ + +F R+F+ + S + F + Sbjct: 167 PTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVFELFSGFMKY 226 Query: 238 LPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEI 297 P H + ++I + ++ R D RD ID+ L+ + + T+ Sbjct: 227 FPGAH-RQITRNLQEILDYVGQSVEKHRATLDPSNPRDFIDTYLLRMEKEKSNQHTEFHH 285 Query: 298 ANLLIG---ILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYE 354 NLLI + G T+++T + L + + PH+ + + +E+ +++ G T E Sbjct: 286 QNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVI----GSHRLPTLE 341 Query: 355 DLQKLPSVNNTIKETLRM-HMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSE 413 D K+P + I E R + KVT Y++PK V A Sbjct: 342 DRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLF--RGYLLPKNTEVYPILSSALHDP 399 Query: 414 RYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGE 473 +YF+ P F+P + A S ++PF G+ C+GE Sbjct: 400 QYFEQPGTFNPDHFLDANGALKK--------------------SEAFMPFSIGKRICLGE 439 Query: 474 QFAYVQLGTILTTFVYNLRWT 494 A +L TT + N + Sbjct: 440 GIARNELFLFFTTILQNFSVS 460 >5E0E-A nrPDB Length = 463 Score = 248 bits (633), Expect = 4e-66, Method: Composition-based stats. Identities = 89/445 (20%), Positives = 159/445 (35%), Gaps = 57/445 (12%) Query: 72 FESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTT--PVF-GK 128 F R+KYGDVF+ L + + + G E + A + A + P+F G Sbjct: 27 FRRIREKYGDVFTVHLGPRPVVMLYGT---EAIREALVDQAEAFSGRGTIAVVEPIFRGY 83 Query: 129 GVIYDCPNSRLMEQKKFAKFALTTDSF--KRYVPKIREEILNYFVTDESFKLKEKTHGVA 186 GV++ R ++F+ + + +I+EE + ++ Sbjct: 84 GVVFA-NGERWKALRRFSLVTMRDFGMGKRSVEERIQEEARCLVE-----EFRKSQGAPL 137 Query: 187 NVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDL-----------DKGFTPINFVF 235 + IT +FG E D F +L + F + Sbjct: 138 DPTFLFQCITANIICSIVFG-ERFDYKDHQFLRLLYLFYQSFSLISSFSSQVFELFSGFL 196 Query: 236 PNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQ 295 P H + ++I + ++ R D RD ID+ L+ + + T+ Sbjct: 197 KYFPGTH-RQISRNLQEILDYIGQSVEKHRATLDPSHPRDFIDTYLLRMEKEKSNQHTEF 255 Query: 296 EIANLLIG---ILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLT 352 + NL+I + G TS++T + L + + PH+ + + +E+ +++ G T Sbjct: 256 DHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVI----GSHRLPT 311 Query: 353 YEDLQKLPSVNNTIKETLRMHMPLH-SIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHT 411 ED K+P I E R + + KVT Y++PK V A Sbjct: 312 LEDRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLF--RGYLLPKNTEVYPILSSALH 369 Query: 412 SERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCI 471 +YF+ P+ F+P + A S ++PF G+ C+ Sbjct: 370 DPQYFEQPDTFNPDHFLDANGALKK--------------------SEAFMPFSIGKRICL 409 Query: 472 GEQFAYVQLGTILTTFVYNLRWTID 496 GE A +L TT + N + Sbjct: 410 GEGIARNELFLFFTTILQNFSLSSP 434 >2PG7-A nrPDB Length = 476 Score = 244 bits (623), Expect = 6e-65, Method: Composition-based stats. Identities = 95/503 (18%), Positives = 175/503 (34%), Gaps = 60/503 (11%) Query: 45 KDRAPLVFYWIPWFGSAASYGQQP-YEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEF 103 K + P +P+ G+ + Y ++YG VF+ L + + V G H+ Sbjct: 8 KGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCG---HDA 64 Query: 104 VFNAKLSDVSAEDAYKHLTTPVF---GKGVIYDCPNSRLMEQKKFAKFALT--TDSFKRY 158 V A + T + G GV++ R + ++F+ L + Sbjct: 65 VREALVDQAEEFSGRGEQATFDWVFKGYGVVFS-NGERAKQLRRFSIATLRDFGVGKRGI 123 Query: 159 VPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFA 218 +I+EE L+ + S +FGD D+ F Sbjct: 124 EERIQEEAGFLIDA-----LRGTGGANIDPTFFLSRTVSNVISSIVFGDRF-DYKDKEFL 177 Query: 219 QLYSDLDKGF-----------TPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRER 267 L + F + V +LP P Q + K+++ + Sbjct: 178 SLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQ-GLEDFIAKKVEHNQRT 236 Query: 268 GDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIG---ILMGGQHTSASTSAWFLLHLG 324 D + RD IDS LI ++ T+ + NL++ + +GG T ++T + L L Sbjct: 237 LDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLM 296 Query: 325 EKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRM-HMPLHSIFRKV 383 + P ++ +++E+ ++ G +ED K+P + I E R + S+ R+V Sbjct: 297 KHPEVEAKVHEEIDRVI----GKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRV 352 Query: 384 TNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSD 443 + ++ +PKG V G +F NP+DF+P + + Sbjct: 353 KKDTKF--RDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKK------- 403 Query: 444 EVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRW--TIDGYKVP 501 S ++PF G+ C GE A ++L TT + N R + + Sbjct: 404 -------------SDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDID 450 Query: 502 DPDYSSMVVLPTEPAEIIWEKRE 524 + + R Sbjct: 451 VSPKHVGFATIPRNYTMSFLPRH 473 >3MDV-A nrPDB Length = 456 Score = 243 bits (621), Expect = 1e-64, Method: Composition-based stats. Identities = 99/474 (20%), Positives = 188/474 (39%), Gaps = 66/474 (13%) Query: 70 EFFESCRQKYGDVFSFMLLGKIMTVYLGPKG-HEFVFNAKLSDVSAEDAYKHLTT----P 124 + F +KYG V + K + P+ +F+ + K + S Y+ L T Sbjct: 14 DVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDS--KMYRALQTVFGER 71 Query: 125 VFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHG 184 +FG+G++ +C R +Q++ A + S + E+ E+ K G Sbjct: 72 LFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEA-----KADG 126 Query: 185 VANVMKTQPEITIFTA----SRSLFGDEMRRIF--DRSFAQLYSDLDKGFTPINFVFPNL 238 V + ++ +TA +++ FG E + + +Q + +G T Sbjct: 127 QTPV--SMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKF 184 Query: 239 PLPHYWRRDAAQKKISATYMKEI-----KSRRE---RGDIDPNRDLIDSLLIHSTYKDGV 290 LP R+ + + S +++++ + RRE RG+ P L L +D Sbjct: 185 -LPG-KRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQD-- 240 Query: 291 KMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLND 350 D+ + + + + G TSA+ A+ ++ L +P + + EV E++ G Sbjct: 241 ---DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVI----GSKRY 293 Query: 351 LTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAH 410 L +EDL +L ++ +KE+LR++ P FR + I VP +L S Sbjct: 294 LDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLID--GVRVPGNTPLLFSTYVMG 351 Query: 411 TSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRC 470 + YF++P F+P R+ A K Y PF G C Sbjct: 352 RMDTYFEDPLTFNPDRFGPGAPKPRFT----------------------YFPFSLGHRSC 389 Query: 471 IGEQFAYVQLGTILTTFVYNLRW-TIDGYKVPDPDYSSMVVLPTEPAEIIWEKR 523 IG+QFA +++ ++ + L + + G + + +++ P +P R Sbjct: 390 IGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATL--KPLDPVLCTLRPR 441 >6DA2-A nrPDB Length = 487 Score = 243 bits (620), Expect = 1e-64, Method: Composition-based stats. Identities = 89/488 (18%), Positives = 167/488 (34%), Gaps = 42/488 (8%) Query: 50 LVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKL 109 +P+ G+ SY + F C +KYG V+ F + + P + + + Sbjct: 19 PGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDP---DMIKTVLV 75 Query: 110 SDVSAEDAYKHLTTPV-FGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILN 168 + + + PV F K I + + T+ K VP I + Sbjct: 76 KECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDV 135 Query: 169 YFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFD-----RSFAQLYSD 223 K + +V I + S + D + D + Sbjct: 136 LVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDF 195 Query: 224 LDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLID--SLL 281 LD F I +P+ ++++ K +K +E D + +D L+ Sbjct: 196 LDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLM 255 Query: 282 IHSTYKDGVK----MTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEV 337 I S + ++D E+ I + G T++S ++ + L P +Q + +E+ Sbjct: 256 IDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI 315 Query: 338 VELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVP 397 +L K TY+ + ++ ++ + ETLR+ + R + I +P Sbjct: 316 DAVLPNKA----PPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI--NGMFIP 369 Query: 398 KGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVS 457 KG V++ H +Y+ PE F P R+ Sbjct: 370 KGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK--------------------DNIDP 409 Query: 458 SPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGY-KVPDPDYSSMVVLPTEPA 516 Y PFG G CIG +FA + + L + N + ++P ++ P +P Sbjct: 410 YIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPV 469 Query: 517 EIIWEKRE 524 + E R+ Sbjct: 470 VLKVESRD 477 >5VBU-A nrPDB Length = 476 Score = 241 bits (615), Expect = 5e-64, Method: Composition-based stats. Identities = 93/502 (18%), Positives = 180/502 (35%), Gaps = 62/502 (12%) Query: 42 SLRKDRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGH 101 S + PL ++ + QK+G ++ L + + V + Sbjct: 6 SSKGKLPPLAPGFL----HLLQ--PDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTI 59 Query: 102 EFVFNAKLSDVSAE---DAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRY 158 E K +D + YK ++ + + KK + AL Sbjct: 60 EEAMVKKWADFAGRPEPLTYKLVSRNY--PDLSLGDYSLLWKAHKKLTRSALLLGIRDSM 117 Query: 159 VPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFA 218 P + + + E + + T + +I FGD+++ D Sbjct: 118 EPVVEQLTQEF---CERMRAQPGTPVAIEEEFSLLTCSIICYLT--FGDKIKD--DNLMP 170 Query: 219 QLYSDLDKGFTPIN----------FVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERG 268 Y + + + P P R A +K +++ +E Sbjct: 171 AYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESL 230 Query: 269 DIDPNRDLIDSLLIH----STYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLG 324 RD++D +L S + ++ + + + +L+GG T+A+T +W ++ L Sbjct: 231 VAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLL 290 Query: 325 EKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLH-SIFRKV 383 P +Q + +E+ L G + + Y+D +LP +N TI E LR+ + ++ + Sbjct: 291 HHPEIQQRLQEELDHELG-PGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRT 349 Query: 384 TNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSD 443 T P I + Y +P+G ++ + AH E ++ P +F P R+ Sbjct: 350 TRPSSI--SGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEP------------- 394 Query: 444 EVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVP-- 501 G +S L FG G C+GE A ++L +LT + G +P Sbjct: 395 -----------GKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSL 443 Query: 502 DPDYSSMVVLPTEPAEIIWEKR 523 P V+L +P ++ + R Sbjct: 444 QPLPHCSVILKMQPFQVRLQPR 465 >4R20-A nrPDB Length = 486 Score = 241 bits (614), Expect = 7e-64, Method: Composition-based stats. Identities = 81/470 (17%), Positives = 158/470 (33%), Gaps = 45/470 (9%) Query: 68 PYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVF- 126 P+ F +YG +F + V V + + + K +TT + Sbjct: 41 PHLLFTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRP--KMVTTDLLT 98 Query: 127 --GKGVIYDCPNSRLMEQKKFAKFALT-----TDSFKRYVPKIREEILNYFVTDESFKLK 179 GK + + + ++ + T ++ + V + + + Sbjct: 99 QGGKDIAFADYSPLWKNHRRLVHSSFTLFGEGSNKLQTIVQEAADSLCEELQACRGQSSD 158 Query: 180 EKTHGVANVMKTQPEITIFTASRSL--FGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPN 237 + V + ++ + + + D + P +FPN Sbjct: 159 LSVVLMRAVTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQTIARGGLVDIFPWLRIFPN 218 Query: 238 LPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDG--VKMTDQ 295 L + + ++ K++ ++ RDL+D+LLI G +T+ Sbjct: 219 KDLKRLKECVSIRDQL---LYKKLLEHKKSLTPGEPRDLLDALLIGQQRGSGGADDITED 275 Query: 296 EIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYED 355 + G T+++T W + L P LQ+ + E+ E + G D Sbjct: 276 HVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECV----GVDRPPCLSD 331 Query: 356 LQKLPSVNNTIKETLRMHMPLHSI-FRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSER 414 LP ++ + E +R+ + + + VPKG VLV+ H + Sbjct: 332 RPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSL--GGHSVPKGTRVLVNMWAIHHDPK 389 Query: 415 YFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQ 474 ++D PE F+P R+ + K K S +LPFG G C+GE Sbjct: 390 HWDQPEQFNPERFLEPSGK--------------------KKTQSSFLPFGAGPRVCVGES 429 Query: 475 FAYVQLGTILTTFVYNLRWTIDGY-KVPDPDYSSMVVLPTEPAEIIWEKR 523 A ++L ++ + ++ +PD VVL E + R Sbjct: 430 LARIELFLFVSRPLQRFSFSCPSEASLPDLQGRFGVVLQPERYTVTVTPR 479 >3DL9-A nrPDB Length = 479 Score = 238 bits (606), Expect = 5e-63, Method: Composition-based stats. Identities = 76/468 (16%), Positives = 160/468 (34%), Gaps = 38/468 (8%) Query: 68 PYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFG 127 P+ + Q YG++FS L G V G + + + Sbjct: 36 PHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKM 95 Query: 128 KGVIYDCPNSRLMEQKKFAKFALTTDSF--KRYVPKIREEILNYFVTDESFKLK--EKTH 183 G++ ++ ++ A + + K + KI EE + E++K + + Sbjct: 96 GGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQ 155 Query: 184 GVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHY 243 + N + + IF R + D + F++ + FP + + + Sbjct: 156 LITNAVSNITNLIIF-GERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPF 214 Query: 244 WRRDAAQKKIS---ATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVK---MTDQEI 297 + + + + I+ + +D+ L + + + Sbjct: 215 GKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENL 274 Query: 298 ANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQ 357 + +++ G T+ + W +L + P++Q + +E+ ++ G +++D Sbjct: 275 IFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIM----GPNGKPSWDDKC 330 Query: 358 KLPSVNNTIKETLRMHMPLH-SIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYF 416 K+P + E LR + IF + + Y +PKG V+ + H E+Y+ Sbjct: 331 KMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVV--RGYSIPKGTTVITNLYSVHFDEKYW 388 Query: 417 DNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFA 476 +PE F P R+ ++ +PF GR C+GE A Sbjct: 389 RDPEVFHPERFLDSSGYF--------------------AKKEALVPFSLGRRHCLGEHLA 428 Query: 477 YVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIWEKRE 524 +++ T + VPD + L +P I E+R Sbjct: 429 RMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERRH 476 >3QZ1-A nrPDB Length = 496 Score = 237 bits (605), Expect = 7e-63, Method: Composition-based stats. Identities = 100/493 (20%), Positives = 179/493 (36%), Gaps = 57/493 (11%) Query: 48 APLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNA 107 PLV ++ P QK G V+ L + + V + E Sbjct: 31 PPLVPGFL----HLLQ-PNLPIHLLS-LTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIR 84 Query: 108 KLSDVSAEDA---YKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFAL---TTDSFKRYVPK 161 K D + YK ++ + + + KK + AL T S + +V + Sbjct: 85 KWVDFAGRPQIPSYKLVSQRC--QDISLGDYSLLWKAHKKLTRSALLLGTRSSMEPWVDQ 142 Query: 162 IREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSL---FGDEMRRIFDRSFA 218 + +E + + +T +L F D ++ + Sbjct: 143 LTQEFCERMRVQAGAPVTIQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQDLMKTWDH 202 Query: 219 QLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLID 278 LD P FPN P WR A + K+++ +E RD+ D Sbjct: 203 WSIQILD--MVPFLRFFPN---PGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWRDMTD 257 Query: 279 SLLI---HSTYKDGV-KMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIY 334 +L ++G ++ + + ++ + +GG T+AST +W + L P +Q + Sbjct: 258 YMLQGVGRQRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQ 317 Query: 335 QEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLH-SIFRKVTNPLRIPETN 393 +E+ L G + +TY+D +LP +N TI E LR+ + ++ + T P I Sbjct: 318 EELDRELG-PGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSI--FG 374 Query: 394 YIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVS 453 Y +P+G V+ + AH E ++ P +F P R+ A ++ Sbjct: 375 YDIPEGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGANPSA----------------- 417 Query: 454 KGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGY-KVP--DPDYSSMVV 510 L FG G C+GE A ++L +L + +P PD V Sbjct: 418 -------LAFGCGARVCLGESLARLELFVVLARLLQAFTLLPPPVGALPSLQPDPYCGVN 470 Query: 511 LPTEPAEIIWEKR 523 L +P ++ + R Sbjct: 471 LKVQPFQVRLQPR 483 >4R1Z-A nrPDB Length = 439 Score = 233 bits (593), Expect = 2e-61, Method: Composition-based stats. Identities = 83/414 (20%), Positives = 146/414 (35%), Gaps = 45/414 (10%) Query: 127 GKGVIYDCPNSRLMEQKKFAKFAL-----TTDSFKRYVPKIRE---EILNYFVTDESFKL 178 GK + + +S +K AL + S ++ + + E+L Sbjct: 42 GKDIAFADYSSTWKFHRKMVHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLG 101 Query: 179 KEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNL 238 E T V NV+ + + + F + M + + D P +FPN Sbjct: 102 PELTRAVTNVVCALCFNSSYKRGDAEF-ESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNK 160 Query: 239 PLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVK------- 291 L + + + K+ K+ + + + RDL+D+LL + Sbjct: 161 DLTILRQCISIRDKL---LQKKYEEHKVTYSDNVQRDLLDALLRAKRSSENNNSSTRDVG 217 Query: 292 MTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDL 351 +T+ + + I G T+ + W + +L P +Q I +E+ K G Sbjct: 218 LTEDHVLMTVGDIFGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELD----SKIGKERHP 273 Query: 352 TYEDLQKLPSVNNTIKETLRMHMPLHSI-FRKVTNPLRIPETNYIVPKGHYVLVSPGYAH 410 D LP + TI+E LR+ + + Y V KG V+++ H Sbjct: 274 QLSDRGNLPYLEATIREVLRIRPVSPLLIPHVALQDSSV--GEYTVQKGTRVVINLWSLH 331 Query: 411 TSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRC 470 ++ + NPE FDP R+ S YLPFG G C Sbjct: 332 HDKKEWKNPELFDPGRFLNEEGDGLCCP------------------SGSYLPFGAGVRVC 373 Query: 471 IGEQFAYVQLGTILTTFVYNLRWTID-GYKVPDPDYSSMVVLPTEPAEIIWEKR 523 +GE A ++L L + + G +PD VVL + +++ + R Sbjct: 374 LGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPKKFKVVAKVR 427 >5VEU-A nrPDB Length = 480 Score = 230 bits (587), Expect = 8e-61, Method: Composition-based stats. Identities = 91/490 (18%), Positives = 171/490 (34%), Gaps = 47/490 (9%) Query: 50 LVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKL 109 +P G+ SY Q ++F C +KYG ++ + P + + + Sbjct: 18 PGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDP---DVIRTVLV 74 Query: 110 SDVSAEDAYKHLTTPV-FGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILN 168 + + + PV F K I + + T+ K P I + Sbjct: 75 KECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDV 134 Query: 169 YFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFD------RSFAQLYS 222 K K + ++ I S + D + D + F + + Sbjct: 135 LVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLK-FG 193 Query: 223 DLDKGFTPINFVFPNL-PLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLID--S 279 LD F I +FP L P+ K K + ++ D + +D Sbjct: 194 FLDPLFLSI-ILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQ 252 Query: 280 LLIHSTYKDGVK----MTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQ 335 L+I S + ++D E+A I + G T++S ++ L L P +Q + + Sbjct: 253 LMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQK 312 Query: 336 EVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYI 395 E+ +L K TY+ + ++ ++ + ETLR+ + R + I Sbjct: 313 EIDAVLPNKA----PPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI--NGVF 366 Query: 396 VPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKG 455 +PKG V++ H +Y+ PE+F P R+ + Sbjct: 367 IPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSID-------------------- 406 Query: 456 VSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGY-KVPDPDYSSMVVLPTE 514 Y PFG G CIG +FA + + L + N + ++P + ++ P + Sbjct: 407 -PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEK 465 Query: 515 PAEIIWEKRE 524 P + + R+ Sbjct: 466 PIVLKVDSRD 475 >5UYS-A nrPDB Length = 494 Score = 226 bits (575), Expect = 2e-59, Method: Composition-based stats. Identities = 96/502 (19%), Positives = 172/502 (34%), Gaps = 61/502 (12%) Query: 47 RAPLVFYWIPWF---GSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEF 103 PLV +P+ G + F ++KYG ++S + K + + + Sbjct: 15 SLPLV-GSLPFLPRHGHM-------HNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKE 66 Query: 104 VFNAKLSDVSAEDAYKHLTTPVFGK-GVIYDCPNSRL--MEQKKFAKFALTTDSFKRYVP 160 V K D S L + G+ + + + A FAL D ++ Sbjct: 67 VLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEK 126 Query: 161 KIREEI---LNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSF 217 I +EI + T + V I T+ ++ GD + Sbjct: 127 IICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKN--GDPELNVIQNYN 184 Query: 218 AQLYSDLDKG----FTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPN 273 + +L K P +FPN L + + K +++ +E+ D Sbjct: 185 EGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLN---KILENYKEKFRSDSI 241 Query: 274 RDLIDSLLIHSTYKDGVK---------MTDQEIANLLIGILMGGQHTSASTSAWFLLHLG 324 +++D+L+ D ++D I + I G T+ S W L L Sbjct: 242 TNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLL 301 Query: 325 EKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSI-FRKV 383 P ++ +Y+E+ + G T D +L + TI+E LR+ + K Sbjct: 302 HNPQVKKKLYEEID----QNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKA 357 Query: 384 TNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSD 443 I + V KG V+++ H +E+ + P+ F P R+ A Sbjct: 358 NVDSSI--GEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISP----- 410 Query: 444 EVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGY-KVPD 502 S YLPFG G CIGE A +L I+ + + ++P Sbjct: 411 -------------SVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPS 457 Query: 503 PDYSSMVVLPTEPAEIIWEKRE 524 + VV + ++ + R+ Sbjct: 458 LEGIPKVVFLIDSFKVKIKVRQ 479 >6C94-A nrPDB Length = 497 Score = 214 bits (545), Expect = 7e-56, Method: Composition-based stats. Identities = 82/432 (18%), Positives = 157/432 (36%), Gaps = 50/432 (11%) Query: 88 LGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAK 147 +G+ + + D A D Y + GKG++ + + +K Sbjct: 63 VGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWI-GKGLLV-LDGPKWFQHRKLLT 120 Query: 148 FALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFG- 206 D K YV + + E ++ K ++ + + T + FG Sbjct: 121 PGFHYDVLKPYVAIFADSTR---IMLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGK 177 Query: 207 -DEMRRIFDRS-------FAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYM 258 D D S L F N L PH R A + Sbjct: 178 GDSGLNHRDSSYYVAVSELTLLMQQRIDSFQYHNDFIYWLT-PHGRRFLRACRAAHDHTD 236 Query: 259 KEIKSRRERGDIDPNR---------DLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQ 309 + I+ R+ + R D +D +L+ + GV+++D ++ + + G Sbjct: 237 RVIRQRKAALQDEKEREKIQNRRHLDFLD-ILLDVRGESGVQLSDTDLRAEVDTFMFEGH 295 Query: 310 HTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKET 369 T+ S +WFL + P Q +EV E+L GD + +EDL K+ + +KE Sbjct: 296 DTTTSGISWFLYCMALYPEHQQRCREEVREIL----GDQDSFQWEDLAKMTYLTMCMKEC 351 Query: 370 LRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDT 429 R++ P+ ++R+++ P+ + +P G + + H + + +PE FDP R+ Sbjct: 352 FRLYPPVPQVYRQLSKPVSFVDGR-SLPAGSLISLHIYALHRNSDVWPDPEVFDPLRFSP 410 Query: 430 AAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVY 489 + ++PF G CIG+QFA ++ + + Sbjct: 411 ENSSGRH--------------------PYAFIPFSAGPRNCIGQQFAMNEMKVVTALCLL 450 Query: 490 NLRWTIDGYKVP 501 +++D ++P Sbjct: 451 RFEFSVDPLRLP 462 >6IQ5-A nrPDB Length = 463 Score = 211 bits (537), Expect = 6e-55, Method: Composition-based stats. Identities = 80/484 (16%), Positives = 171/484 (35%), Gaps = 54/484 (11%) Query: 68 PYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKG-HEFVFN--AKLSDVSAEDAYKHLTTP 124 + F ++YGDVF L + V G + H+ + + +D + +++ ++ Sbjct: 3 AHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVSG- 61 Query: 125 VFGKGVIYDCPNSRLMEQKKFAKFALTT--DSFKRYVPKIREEILNYFVTDESFKLKEKT 182 G+ + + + Q++ A + R + +L+ + ++ Sbjct: 62 --GRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSA 119 Query: 183 HG------------VANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTP 230 G VANVM ++ F E+ + + + P Sbjct: 120 DGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEF-RELLSHNEEFGRTVGAGSLVDVMP 178 Query: 231 INFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRER-GDIDPNRDLIDSLLIHSTYK-- 287 FPN + + + S + + E RD++D+ ++ + K Sbjct: 179 WLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAA 238 Query: 288 -----DGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLK 342 G ++ + + + I Q T ++ W LL P +Q + E+ +++ Sbjct: 239 GDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVV- 297 Query: 343 EKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHS-IFRKVTNPLRIPETNYIVPKGHY 401 G D LP V + E +R + I T + Y +PK Sbjct: 298 ---GRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVL--GYHIPKDTV 352 Query: 402 VLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYL 461 V V+ + + NPE+FDP R+ G ++K ++S + Sbjct: 353 VFVNQWSVNHDPVKWPNPENFDPARFLDKD------------------GLINKDLTSRVM 394 Query: 462 PFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIWE 521 F G+ RCIGE+ + +QL ++ + + + + ++S + + + ++ Sbjct: 395 IFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVT 454 Query: 522 KRET 525 RE+ Sbjct: 455 LRES 458 >4KPA-A nrPDB Length = 494 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 69/432 (15%), Positives = 148/432 (34%), Gaps = 35/432 (8%) Query: 67 QPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVF 126 +P + + G++F F G++ + + + D + A K Sbjct: 48 KPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKF-VRDFA 106 Query: 127 GKGVIYDCPNSR-LMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGV 185 G G+ + + + + + + K Y + + + E E Sbjct: 107 GDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVP 166 Query: 186 ANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPL--PHY 243 ++ + + F R + LD+ + P+ P + Sbjct: 167 EDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENK 226 Query: 244 WRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIG 303 + K ++ K I R+ G+ + DL+ +L + G + D+ I +I Sbjct: 227 RQFQEDIKVMNDLVDKIIADRKASGE--QSDDLLTHMLNGKDPETGEPLDDENIRYQIIT 284 Query: 304 ILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVN 363 L+ G T++ ++ L L + PH+ +E +L + +Y+ +++L V Sbjct: 285 FLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPV-----PSYKQVKQLKYVG 339 Query: 364 NTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYF-DNPEDF 422 + E LR+ + + Y + KG ++V H + + D+ E+F Sbjct: 340 MVLNEALRLWPTAPAFSLYAKEDTVL-GGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEF 398 Query: 423 DPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGT 482 P R++ +A + PFG G+ CIG+QFA + Sbjct: 399 RPERFENPSAIPQH----------------------AFKPFGNGQRACIGQQFALHEATL 436 Query: 483 ILTTFVYNLRWT 494 +L + + + Sbjct: 437 VLGMMLKHFDFE 448 >2IAG-A nrPDB Length = 482 Score = 194 bits (493), Expect = 7e-50, Method: Composition-based stats. Identities = 84/498 (16%), Positives = 177/498 (35%), Gaps = 38/498 (7%) Query: 42 SLRKDRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGH 101 + R PL IPW G A +G+ F ++K+GD+F+ ++ G+ +TV L P + Sbjct: 2 TRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSY 61 Query: 102 EFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPK 161 + V + + L +F + + P+ ++K K L + Sbjct: 62 DAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPS----DEKARMKLTLLHRELQALTEA 117 Query: 162 IREEILNYFVTDESF-KLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQL 220 + + + D + G+ + + + +L+G E S AQ Sbjct: 118 MYTNLHAVLLGDATEAGSGWHEMGLLDFSYS---FLLRAGYLTLYGIEALPRTHESQAQD 174 Query: 221 ---YSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLI 277 +D+ F ++ + P L D + + ++ S + Sbjct: 175 RVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWL 234 Query: 278 DSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEV 337 +S L+H ++++ A L+ L Q + W LL L + P + E+ Sbjct: 235 ESYLLHLEEMG---VSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGEL 291 Query: 338 VELL---KEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIP---E 391 +L ++ L + L P +++ + E+LR+ I R+V L +P Sbjct: 292 ESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-TAAPFITREVVVDLAMPMADG 350 Query: 392 TNYIVPKGHYVLVSPGYA-HTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFG 450 + + +G +L+ P + + +PE F R+ + + Sbjct: 351 REFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLK---- 406 Query: 451 KVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPD-----Y 505 + +P+G G + C+G +A + + + +L + V P+ Y Sbjct: 407 -------NYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRY 459 Query: 506 SSMVVLPTEPAEIIWEKR 523 ++ P + + R Sbjct: 460 GFGLMQPEHDVPVRYRIR 477 >3K9V-A nrPDB Length = 482 Score = 191 bits (484), Expect = 7e-49, Method: Composition-based stats. Identities = 86/492 (17%), Positives = 163/492 (33%), Gaps = 54/492 (10%) Query: 50 LVFYWIPWFGSAASY-----GQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFV 104 P GS ++ ++ +KYG +F L P E + Sbjct: 27 PGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEAL 86 Query: 105 F-----NAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYV 159 + + + ++ AY+ +G ++ R+ F K + + Sbjct: 87 YRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRS--AFQKKLMKPVEIMKLD 144 Query: 160 PKIREEILNYFVTDESF--KLKEKTHGVANVMKTQPEITIFTASRSLFG------DEMRR 211 KI E + ++ + + + + K E FG +E Sbjct: 145 KKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEEEAL 204 Query: 212 IFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDID 271 F + + S K + L + A I + I +R +R Sbjct: 205 TFITAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCIDNRLQRYSQQ 264 Query: 272 PNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQD 331 P D + + ++ +E+ + + + T+A++ W L +L P Q Sbjct: 265 PGADFLCDIYQQ------DHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQR 318 Query: 332 VIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPE 391 + QEV +L D EDL+ +P + +KE++R+ + R + P + Sbjct: 319 RLLQEVQSVL----PDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKPTVL-- 372 Query: 392 TNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGK 451 Y +PKG + ++ +SE F++ F P RW K Sbjct: 373 GEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQ---------------------K 411 Query: 452 VSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVL 511 K +LPFG G+ CIG + A +QL L + + P +++ Sbjct: 412 EKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYD-IVATDNEPVEMLHLGILV 470 Query: 512 PTEPAEIIWEKR 523 P+ I + R Sbjct: 471 PSRELPIAFRPR 482 >3MZS-A nrPDB Length = 486 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 82/467 (17%), Positives = 176/467 (37%), Gaps = 58/467 (12%) Query: 77 QKYGDVFSFMLLGKIMTVYLGPKGHEFVFN-----AKLSDVSAEDAY-KHLTTPVFGKGV 130 QKYG ++ L + P+ +F + D+ AY ++ P+ GV Sbjct: 45 QKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPI---GV 101 Query: 131 IYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESF-KLKEKTHGVANVM 189 ++ + ++ + ++ K ++P + ++ K + V ++ Sbjct: 102 LFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIK 161 Query: 190 KTQPEITIFTASRSLFGD------EMRRIFDRSFAQLYSDLDKGFTPINFVFP---NLPL 240 + + + +FG+ E + F + P+ V P L Sbjct: 162 EDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFR 221 Query: 241 PHYWRRDAA-----QKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQ 295 WR A K + R + + ++ LL KM + Sbjct: 222 TKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLL------KSEKMLLE 275 Query: 296 EIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYED 355 ++ + +L GG +T++ T W L + ++Q+++ +EV+ ++ GD++ + Sbjct: 276 DVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKM---- 331 Query: 356 LQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERY 415 LQ +P + +IKETLR+H ++ R + L + +Y++P V V+ + Sbjct: 332 LQMVPLLKASIKETLRLHPISVTLQRYPESDLVL--QDYLIPAKTLVQVAIYAMGRDPAF 389 Query: 416 FDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQF 475 F +P+ FDPTRW + L FG G +C+G + Sbjct: 390 FSSPDKFDPTRWLSKDKDLIHF---------------------RNLGFGWGVRQCVGRRI 428 Query: 476 AYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIWEK 522 A +++ L + N + + D + ++++ P +P +++ Sbjct: 429 AELEMTLFLIHILENFKVEMQHIGDVDTIF-NLILTPDKPIFLVFRP 474 >3N9Z-A nrPDB Length = 487 Score = 184 bits (467), Expect = 8e-47, Method: Composition-based stats. Identities = 90/470 (19%), Positives = 180/470 (38%), Gaps = 61/470 (12%) Query: 74 SCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVF-----NAKLSDVSAEDAY-KHLTTPVFG 127 QKYG ++ L + P+ +F N + + AY ++ P+ Sbjct: 40 QNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPI-- 97 Query: 128 KGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVA- 186 GV+ + ++ + + ++ K ++P + + FV+ ++K+ G Sbjct: 98 -GVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDA-VSRDFVSVLHRRIKKAGSGNYS 155 Query: 187 -NVMKTQPEITIFTASRSLFGD------EMRRIFDRSFAQLYSDLDKGFTPINFVFPNLP 239 ++ + + +FG+ E+ + F + P+ + P+L Sbjct: 156 GDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLF 215 Query: 240 L--------PHYWRRDAAQKKISATYMKEIKSRRERGDIDPN-RDLIDSLLIHSTYKDGV 290 H D K R++G + + R ++ LL S Sbjct: 216 RLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDS------ 269 Query: 291 KMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLND 350 KM+ ++I + +L GG T++ T W L + +QD++ EV+ + GD+ Sbjct: 270 KMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMAT 329 Query: 351 LTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAH 410 + LQ +P + +IKETLR+H ++ R + N L + +Y++P V V+ Sbjct: 330 M----LQLVPLLKASIKETLRLHPISVTLQRYLVNDLVL--RDYMIPAKTLVQVAIYALG 383 Query: 411 TSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRC 470 +F +PE+FDPTRW + L FG G +C Sbjct: 384 REPTFFFDPENFDPTRWLSKDKNITYF---------------------RNLGFGWGVRQC 422 Query: 471 IGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIW 520 +G + A +++ L + N R I + +++++P +P + Sbjct: 423 LGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTF-NLILMPEKPISFTF 471 >5L94-A nrPDB Length = 410 Score = 173 bits (438), Expect = 2e-43, Method: Composition-based stats. Identities = 71/431 (16%), Positives = 140/431 (32%), Gaps = 92/431 (21%) Query: 103 FVFNAKLSDVSAEDAYKHLTTPV-------FGKGVIYDCPNSRLMEQKKFAKFALTTDSF 155 F ++ + ++ + P G +I + + E + A T + Sbjct: 50 FHYDGVKEVLEQKNIFSSDRRPPQNQRQTALGTSLI-NIDPPKHAEMRALVNKAFTPKAM 108 Query: 156 KRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDE--MRRIF 213 K + PKI E E V ++ P + I D+ + Sbjct: 109 KAWEPKIARITNELLQEVEHL---EDIDIVEHLSYPLPVMVIADILGVPIEDQRQFKDWS 165 Query: 214 DRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPN 273 D A ++ + + + A ++ + + I+ +R R P Sbjct: 166 DIIVAGPSNNERETLEKLQ-----------QEKMKANDELETYFYRIIEEKRTR----PG 210 Query: 274 RDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVI 333 D+I LL ++G ++TD+EI I +L+ G T+ + + + L E + + Sbjct: 211 DDIISVLL--QAKEEGKQLTDEEIVGFSILLLIAGNETTTNLISNTIYCLMEDKASFERL 268 Query: 334 YQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETN 393 +E + + I+E LR P+ ++ R V + + Sbjct: 269 KREKE----------------------LLPSGIEEVLRYRSPVQALHRIVKEDVTL--AG 304 Query: 394 YIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVS 453 + G +V+ G AH YF++PE F R Sbjct: 305 KKLKAGEHVVPWMGSAHRDAEYFEDPEVFKIDR--------------------------- 337 Query: 454 KGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPT 513 + ++ FG G H C+G A ++ +L + P D+S L Sbjct: 338 --KPNVHMAFGRGIHFCLGAPLARIEAKIMLAELIDRY---------PQMDWSPSFELKP 386 Query: 514 EPAEIIWEKRE 524 + ++ +E Sbjct: 387 IESTFVYGLKE 397 >3NC3-A nrPDB Length = 441 Score = 172 bits (435), Expect = 4e-43, Method: Composition-based stats. Identities = 77/430 (17%), Positives = 149/430 (34%), Gaps = 68/430 (15%) Query: 63 SYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLT 122 + PY +F R++ V + + H+ + + D+ + Sbjct: 50 QFQNNPYAYFSQLREE-DPVHYEESIDSYFI----SRYHDVRYILQHPDIFTTKSLVERA 104 Query: 123 TPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKT 182 PV V+ +++ + D+ P I++ N Sbjct: 105 EPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALDHLSPLIKQNAENLLAPY-------LE 157 Query: 183 HGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPH 242 G ++++ + + + G + R ++ +S + T I+ P Sbjct: 158 RGKSDLVNDFGKTFAVCVTMDMLGLDKRDH--EKISEWHSGVADFITSISQS-PEARAHS 214 Query: 243 YWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLI 302 W +++S M IK RR ++P DLI S+L S Y+ G+ ++D++I L++ Sbjct: 215 LW----CSEQLSQYLMPVIKERR----VNPGSDLI-SILCTSEYE-GMALSDKDILALIL 264 Query: 303 GILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSV 362 +L+ + T A + HL P + + D +P Sbjct: 265 NVLLAATEPADKTLALMIYHLLNNPEQMNDV-------------------LADRSLVP-- 303 Query: 363 NNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDF 422 I ETLR P+ I R+++ + + K V G A+ F+ P+ F Sbjct: 304 -RAIAETLRYKPPVQLIPRQLSQDTVV--GGMEIKKDTIVFCMIGAANRDPEAFEQPDVF 360 Query: 423 DPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGT 482 + R D A S ++ +L FG G H C+G FA ++ Sbjct: 361 NIHREDLGIKSAFSG-------------------AARHLAFGSGIHNCVGTAFAKNEIEI 401 Query: 483 ILTTFVYNLR 492 + + +R Sbjct: 402 VANIVLDKMR 411 >5XJN-A nrPDB Length = 455 Score = 170 bits (429), Expect = 2e-42, Method: Composition-based stats. Identities = 82/436 (18%), Positives = 143/436 (32%), Gaps = 89/436 (20%) Query: 67 QPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKG---HEFVFNAKLSDVSAEDAYKHLTT 123 P+ ++ RQ+ +F + ++T Y K F+++ + T Sbjct: 63 NPFPAYKELRQEEPVMFDERIGYWVVTKYDDIKTTFDDWETFSSENAQAPVRKRGPQATQ 122 Query: 124 PVFGKG-----VIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKL 178 + G + + A+ A T +K P IR +++ E Sbjct: 123 IMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTPRRYKALEPDIRAMVIDRV---EKMLA 179 Query: 179 KEKTHG--VANVMKTQPEITIFT---ASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINF 233 ++ G V+++ P ITI T A S+ D +R D A + DL Sbjct: 180 NDQHVGDMVSDLAYDIPTITILTLIGADISMV-DTYKRWSDSRAAMTWGDLSDE------ 232 Query: 234 VFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMT 293 +P H + + + G + DL+ + ++G ++T Sbjct: 233 --EQIPHAHNL------VEYWQECQRMVADAHAHGGDNLTADLVRA------QQEGQEIT 278 Query: 294 DQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTY 353 D EIA+LL +L G T+ + + L + P I Sbjct: 279 DHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAI-------------------L 319 Query: 354 EDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSE 413 E+ + +P + E LR + RK I + +G VL+ G A+ E Sbjct: 320 ENPKLIP---AAVDEVLRYSGSIVGWRRKALKDTEI--GGVAIKEGDGVLLLMGSANRDE 374 Query: 414 RYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGE 473 F+N E+FD +R + +L FG G H C+G Sbjct: 375 ARFENGEEFDISR----------------------------ANAREHLSFGFGIHYCLGN 406 Query: 474 QFAYVQLGTILTTFVY 489 A +Q L Sbjct: 407 MLAKLQAKICLEEVTR 422 >2VZM-A nrPDB Length = 436 Score = 169 bits (428), Expect = 3e-42, Method: Composition-based stats. Identities = 84/465 (18%), Positives = 160/465 (34%), Gaps = 105/465 (22%) Query: 63 SYGQQPYEFFESCRQKYGDVFSFMLL-GKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHL 121 + PY + R + G G + + +G V L+D +++ Sbjct: 43 DFAADPYPTYARLRAE-GPAHRVRTPEGNEVWLVVGYDRARAV----LADPRFSKDWRNS 97 Query: 122 TTPVFGKGVIYD-----CPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESF 176 TTP+ + R +K T + P+++E + Sbjct: 98 TTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDA---- 153 Query: 177 KLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFP 236 + G A++M++ T L G DR+ ++++D FVFP Sbjct: 154 -MLAAPDGRADLMESLAWPLPITVISELLG---VPEPDRAAFRVWTD--------AFVFP 201 Query: 237 NLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQE 296 + P + A ++S + I S+R + DL+ + L+ ++ +DG ++T +E Sbjct: 202 DDP----AQAQTAMAEMSGYLSRLIDSKRGQD----GEDLLSA-LVRTSDEDGSRLTSEE 252 Query: 297 IANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDL 356 + + +L+ G T+ + A + L P + Sbjct: 253 LLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAAL----------------------R 290 Query: 357 QKLPSVNNTIKETLRMHMPLHS-IFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERY 415 + ++ ++E LR P+ S +R P+ + T ++P G VLV AH + Sbjct: 291 ADMTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGT--VIPAGDTVLVVLADAHRTPER 348 Query: 416 FDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQF 475 F +P FD R ++ +L FG G H CIG Sbjct: 349 FPDPHRFDIRR-----------------------------DTAGHLAFGHGIHFCIGAPL 379 Query: 476 AYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIW 520 A ++ + + + PD + L P E++W Sbjct: 380 ARLEARIAVRALL---------ERCPD------LALDVSPGELVW 409 >5GWE-A nrPDB Length = 405 Score = 169 bits (427), Expect = 3e-42, Method: Composition-based stats. Identities = 82/436 (18%), Positives = 143/436 (32%), Gaps = 89/436 (20%) Query: 67 QPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKG---HEFVFNAKLSDVSAEDAYKHLTT 123 P+ ++ RQ+ +F + ++T Y K F+++ + T Sbjct: 13 NPFPAYKELRQEEPVMFDERIGYWVVTKYDDIKTTFDDWETFSSENAQAPVRKRGPQATQ 72 Query: 124 PVFGKG-----VIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKL 178 + G + + A+ A T +K P IR +++ E Sbjct: 73 IMTDGGFTAYSGLSARIPPEHTRIRAIAQKAFTPRRYKALEPDIRAMVIDRV---EKMLA 129 Query: 179 KEKTHG--VANVMKTQPEITIFT---ASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINF 233 ++ G V+++ P ITI T A S+ D +R D A + DL Sbjct: 130 NDQHVGDMVSDLAYDIPTITILTLIGADISMV-DTYKRWSDSRAAMTWGDLSDE------ 182 Query: 234 VFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMT 293 +P H + + + G + DL+ + ++G ++T Sbjct: 183 --EQIPHAHNL------VEYWQECQRMVADAHAHGGDNLTADLVRA------QQEGQEIT 228 Query: 294 DQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTY 353 D EIA+LL +L G T+ + + L + P I Sbjct: 229 DHEIASLLYSLLFAGHETTTTLISNCFRVLLDHPEQWQAI-------------------L 269 Query: 354 EDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSE 413 E+ + +P + E LR + RK I + +G VL+ G A+ E Sbjct: 270 ENPKLIP---AAVDEVLRYSGSIVGWRRKALKDTEI--GGVAIKEGDGVLLLMGSANRDE 324 Query: 414 RYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGE 473 F+N E+FD +R + +L FG G H C+G Sbjct: 325 ARFENGEEFDISR----------------------------ANAREHLSFGFGIHYCLGN 356 Query: 474 QFAYVQLGTILTTFVY 489 A +Q L Sbjct: 357 MLAKLQAKICLEEVTR 372 >5OFQ-A nrPDB Length = 409 Score = 159 bits (402), Expect = 3e-39, Method: Composition-based stats. Identities = 58/363 (15%), Positives = 130/363 (35%), Gaps = 77/363 (21%) Query: 135 PNSRLMEQKKFAKFALTTDS---FKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKT 191 + + + A T + + ++ +I + +L+ + E F + E G ++ Sbjct: 87 DPPKHTKLRNLVNKAFTPRAIQHLEGHIEEIADYLLDEVSSKEKFDIVEDFAGPLPIIVI 146 Query: 192 QPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQK 251 + + R+LF ++ D + ++ D+ F +R+ Sbjct: 147 AELLGVPIQDRALF----KKYSDDLVSGAENNSDEAFA-----------KMMQKRNEGVI 191 Query: 252 KISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHT 311 + + + I R++ + DLI LL DG +T++E+ I +L+ G T Sbjct: 192 FLQGYFKEIIAERQQ----NKQEDLISLLLEAEI--DGEHLTEEEVLGFCILLLVAGNET 245 Query: 312 SASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLR 371 + + + ++ E +Q+ + +++ V N ++ETLR Sbjct: 246 TTNLITNGVRYMTEDVDVQNEVRRDIS----------------------LVPNLVEETLR 283 Query: 372 MHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAA 431 + P+ +I R + + E + +G V+ A+ F+ P+ F R Sbjct: 284 YYPPIQAIGRIAAEDVELGECK--IKRGQQVISWAASANRDSAKFEWPDTFVVHR----- 336 Query: 432 AKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL 491 ++P++ FG G H C+G A ++ T + Sbjct: 337 ------------------------KTNPHVSFGFGIHFCLGAPLARMEGKIAFTKLLEKG 372 Query: 492 RWT 494 ++ Sbjct: 373 GFS 375 >3S79-A nrPDB Length = 503 Score = 158 bits (400), Expect = 4e-39, Method: Composition-based stats. Identities = 82/466 (17%), Positives = 161/466 (34%), Gaps = 64/466 (13%) Query: 77 QKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFG---KGVIYD 133 + YG+ + G+ + K K + S+ L G KG+I++ Sbjct: 79 RVYGEFMRVWISGEETLII--SKSSSMFHIMKHNHYSSRFG-SKLGLQCIGMHEKGIIFN 135 Query: 134 CPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQP 193 + F AL+ R V E + + E G +V+ Sbjct: 136 NNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEV---TNESGYVDVLTLLR 192 Query: 194 EITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLP-----HYWRRDA 248 + + T S +LF +R D S + + F + + Y + + Sbjct: 193 RVMLDT-SNTLF---LRIPLDESA--IVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEK 246 Query: 249 AQKKISATYMKEIKSRRER----GDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGI 304 + K + I +R R ++ D L++ D +T + + ++ + Sbjct: 247 SVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGD---LTRENVNQCILEM 303 Query: 305 LMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNN 364 L+ T + + + L + + P++++ I +E+ ++ E D+ +D+QKL + N Sbjct: 304 LIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGE-----RDIKIDDIQKLKVMEN 358 Query: 365 TIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDP 424 I E++R + + RK I Y V KG ++++ G H E +F P +F Sbjct: 359 FIYESMRYQPVVDLVMRKALEDDVID--GYPVKKGTNIILNIGRMHRLE-FFPKPNEFTL 415 Query: 425 TRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTIL 484 + + PFG G C G+ A V + IL Sbjct: 416 ENF------------------------AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAIL 451 Query: 485 TTFVYNLRWTIDGYKVPD--PDYSSMVVLPTEP---AEIIWEKRET 525 T + + + + + P E E+I+ R + Sbjct: 452 VTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNS 497 >4GGV-A nrPDB Length = 418 Score = 158 bits (398), Expect = 7e-39, Method: Composition-based stats. Identities = 73/398 (18%), Positives = 130/398 (32%), Gaps = 67/398 (16%) Query: 94 VYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTD 153 VY P+ + + + +G + R + ++ A T Sbjct: 58 VYGYPEAMDILNDHDTFTSDLAHLLPVSVDAPLLEGDMSQMDPPRHRKYRQLVSRAFTPR 117 Query: 154 SFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIF 213 ++ + + E A++ P I I GD R +F Sbjct: 118 LVADMETRVADITRELLDAVDGKPEIEIA---ADLAYPLPVIVIAELLGVPAGD--RDLF 172 Query: 214 DRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPN 273 + D+ +GF+ +F+ + R + + YM + R R P Sbjct: 173 KKWA----DDIIEGFSGFSFLDTSGQGEQDVRDATERLRPLLDYMAGHVTERRRT---PR 225 Query: 274 RDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVI 333 DL+ L+ DG ++TD EI N+ +L+ G T+ T +L L P + + Sbjct: 226 EDLLTHLV--QAEVDGERLTDNEIVNVANILLVTGHITTTMTLGNTVLCLDADPEVAAKV 283 Query: 334 YQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETN 393 D +P I+E LR+ P ++ R + + + T Sbjct: 284 RA-------------------DRSLVP---GAIEEALRVLSPSAALARGTSREVEVAGT- 320 Query: 394 YIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVS 453 ++PK V++ G + R F +PE +DPTR Sbjct: 321 -VIPKDQIVMLWLGAGNRDPRQFTDPEVYDPTR--------------------------- 352 Query: 454 KGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL 491 +P+ FG G H C+G A ++ L Sbjct: 353 --DPNPHFGFGRGIHFCLGAPLARLEGRVALNALFDRF 388 >2WIO-A nrPDB Length = 431 Score = 157 bits (396), Expect = 1e-38, Method: Composition-based stats. Identities = 70/373 (18%), Positives = 114/373 (30%), Gaps = 74/373 (19%) Query: 128 KGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVAN 187 G+I++ +K A T + P+IR+ + G + Sbjct: 104 PGMIHEIDPPEHRALRKVVSSAFTPRTISDLEPRIRDVTRSLLA----------DAGES- 152 Query: 188 VMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRD 247 ++ F ++ E+ + Q + D I P P D Sbjct: 153 --FDLVDVLAFPLPVTIVA-ELLGLPPMDHEQ-FGDWSGALVDIQMDDPTDPALAERIAD 208 Query: 248 AAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMG 307 + +K+R DP DLI L++ DG + D+E AN +L+ Sbjct: 209 -----VLNPLTAYLKARCAERRADPGDDLISRLVLAEV--DGRALDDEEAANFSTALLLA 261 Query: 308 GQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIK 367 G T+ + L E P D ED ++P ++ Sbjct: 262 GHITTTVLLGNIVRTLDEHP-------------------AHWDAAAEDPGRIP---AIVE 299 Query: 368 ETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRW 427 E LR P + R T + +P V A+ D+P+ FDP+R Sbjct: 300 EVLRYRPPFPQMQRTTTKATEV--AGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSRK 357 Query: 428 DTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTF 487 AA+ L FG G H C+G A ++ L Sbjct: 358 SGGAAQ---------------------------LSFGHGVHFCLGAPLARLENRVALEEI 390 Query: 488 VYNL-RWTIDGYK 499 + R T+D Sbjct: 391 IARFGRLTVDRDD 403 >4RM4-A nrPDB Length = 396 Score = 156 bits (395), Expect = 1e-38, Method: Composition-based stats. Identities = 58/365 (15%), Positives = 120/365 (32%), Gaps = 75/365 (20%) Query: 129 GVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANV 188 I + + + + A T K++ P+I+E + F+ + + V + Sbjct: 79 NSIINMDPPKHTKIRSVVNKAFTPRVMKQWEPRIQEITDELI---QKFQGRSEFDLVHDF 135 Query: 189 MKTQPEITI--FTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRR 246 P I I S ++ + D + ++ R Sbjct: 136 SYPLPVIVISELLGVPSAHMEQFKAWSDLLVSTPKDKSEEAEKAF-----------LEER 184 Query: 247 DAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILM 306 D +++++A + I+ +R P +D+I L+ + G K++ +E+ +L+ Sbjct: 185 DKCEEELAAFFAGIIEEKRN----KPEQDIISILV--EAEETGEKLSGEELIPFCTLLLV 238 Query: 307 GGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTI 366 G T+ + + + + E P + + + + + Sbjct: 239 AGNETTTNLISNAMYSILETPGVYEEL----------------------RSHPELMPQAV 276 Query: 367 KETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTR 426 +E LR P + R I +++ +G VL A+ E FD P FD R Sbjct: 277 EEALRFRAPAPVLRRIAKRDTEI--GGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR 334 Query: 427 WDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTT 486 +P++ FG G H C+G A ++ LT+ Sbjct: 335 -----------------------------HPNPHIAFGHGIHFCLGAPLARLEANIALTS 365 Query: 487 FVYNL 491 + Sbjct: 366 LISAF 370 >3EJB-B nrPDB Length = 404 Score = 156 bits (395), Expect = 2e-38, Method: Composition-based stats. Identities = 70/433 (16%), Positives = 140/433 (32%), Gaps = 81/433 (18%) Query: 63 SYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFN----AKLSDVSAEDAY 118 + + PY F+++ R + ++ L G + + + + Sbjct: 10 EFLKNPYSFYDTLRAVH-PIYKGSFLKYPGWYVTGYEETAAILKDARFKVRTPLPESSTK 68 Query: 119 KHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKL 178 + V + +++ + A A T + + Y P I E + + + + Sbjct: 69 YQDLSHVQNQMMLF-QNQPDHRRLRTLASGAFTPRTTESYQPYIIETVHHLL---DQVQG 124 Query: 179 KEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNL 238 K+K +++ I A+ +E R A L +D FT Sbjct: 125 KKKMEVISDFAFPLASFVI--ANIIGVPEEDREQLKEWAASLIQTID--FTRSRK----- 175 Query: 239 PLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIA 298 + + A + + I+ R+ P +D+I LL K+T++E A Sbjct: 176 ---ALTEGNIMAVQAMAYFKELIQKRKRH----PQQDMISMLLKGREKD---KLTEEEAA 225 Query: 299 NLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQK 358 + I + + G T+ + + +L L + P + + Sbjct: 226 STCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPD-------------------- 265 Query: 359 LPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDN 418 + ++E LR P R + + I + +G V + G A+ F N Sbjct: 266 --LIGTAVEECLRYESPTQMTARVASEDIDIC--GVTIRQGEQVYLLLGAANRDPSIFTN 321 Query: 419 PEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYV 478 P+ FD TR +P+L FG G H C+G A + Sbjct: 322 PDVFDITR-----------------------------SPNPHLSFGHGHHVCLGSSLARL 352 Query: 479 QLGTILTTFVYNL 491 + + T + + Sbjct: 353 EAQIAINTLLQRM 365 >5VWS-A nrPDB Length = 393 Score = 151 bits (382), Expect = 5e-37, Method: Composition-based stats. Identities = 68/383 (17%), Positives = 119/383 (31%), Gaps = 74/383 (19%) Query: 109 LSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILN 168 S++ T FGKG I Q++ A T S P+IR+ + Sbjct: 56 YQTFSSDRTRLMPTAQGFGKGGITMIDPPEHRHQRRLITHAFTPQSISAMEPRIRQIADH 115 Query: 169 YFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGF 228 + V + P I I G DR + +SD Sbjct: 116 LLDELPGPEF----DLVEHFAYPLPVIVIAELLGVPPG-------DRHLFRTWSDRLMSL 164 Query: 229 TPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKD 288 N+ P L AA +++ ++ P DL+ L+ + Sbjct: 165 QVENYADPELA----RTVAAAMTEMNDY----LREHCRSRRTHPRDDLLTRLV--QAEVE 214 Query: 289 GVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDL 348 G ++ +E+ N +L+ G T+ +L L + P + + Sbjct: 215 GKRLDLEEVVNTASLLLLAGHLTTTVLIGNTMLCLWDHPEAEKAVRA------------- 261 Query: 349 NDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGY 408 D +P ++E+LR+ P R T + I +P +V+ Sbjct: 262 ------DPSLIP---AALEESLRLRSPFLQAGRVTTRDVTI--AGETIPANRFVMAWILS 310 Query: 409 AHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRH 468 A+ +R F +PE FD R ++ ++ FG G H Sbjct: 311 ANHDDRRFPDPERFDLHR-----------------------------QTTGHIAFGHGVH 341 Query: 469 RCIGEQFAYVQLGTILTTFVYNL 491 C+G Q ++ L + Sbjct: 342 FCLGAQLGRLEGRIALERLLGRF 364 >5CJE-A nrPDB Length = 393 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 67/468 (14%), Positives = 142/468 (30%), Gaps = 91/468 (19%) Query: 60 SAASYGQQPYEFFESCRQKYGDVFSFML----LGKIMTVYLGPKGHEFVFNAKLSDVSAE 115 A + + PY + R++ G V + V + + + +LS + Sbjct: 10 YGARFTEDPYPVYAELRER-GPVHWVRTPPPEAFEGWLVVGHEEARAALADPRLSKDGTK 68 Query: 116 DAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDES 175 L + G ++ + A T + P+I+E + Sbjct: 69 KGLTSLDVELMGPYLLV-VDPPEHTRLRSLVARAFTMRRVEALRPRIQE-------ITDG 120 Query: 176 FKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVF 235 + G A+++ + T L G D+D+ + Sbjct: 121 LLDEMLPRGRADLVDSFAYPLPITVICELLG--------------VPDIDR--VTFRALS 164 Query: 236 PNLPLPHYWRRD-AAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTD 294 + P + AA ++++A + I +R P DL+ L+ + +D +++ Sbjct: 165 NEIVAPTGGDAELAAYERLAAYLDELIDDKRSTA---PADDLLGDLI-RTRAEDDDRLSG 220 Query: 295 QEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYE 354 +E+ + +L+ G T+ + + L P + Sbjct: 221 EELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAAL--------------------- 259 Query: 355 DLQKLPSVNNTIKETLRMHMPL-HSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSE 413 + ++ ++E LR P+ + +R + I + +G V++ A Sbjct: 260 -RADMTLLDGAVEEVLRFEGPVETATYRYAAESMEI--GGTAIAEGDPVMIGLDAAGRDP 316 Query: 414 RYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGE 473 +P FD R +L FG G H C+G Sbjct: 317 ARHPDPHVFDIHR-----------------------------APQGHLAFGHGIHYCLGA 347 Query: 474 QFAYVQLGTILTTFVYNL-RWTIDGYKVPDPDYSSMVVLPTEPAEIIW 520 A ++ L + + +DG P M++ + W Sbjct: 348 PLARLEARVALRSLLERCPDLALDGP--PGARPPGMLIRGVRRLPVRW 393 >6A7J-A nrPDB Length = 411 Score = 146 bits (367), Expect = 3e-35, Method: Composition-based stats. Identities = 64/361 (17%), Positives = 110/361 (30%), Gaps = 79/361 (21%) Query: 133 DCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQ 192 + ALT ++ I + E A Sbjct: 90 TVDGPDHRRLRTLVAQALTVKRVEKLRAGIEALTNASLERLAALPAGEPVDLKAEFAYPL 149 Query: 193 PEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKK 252 P I E+ + +L +K F+ P +P Sbjct: 150 PMNVI---------SELMGVDAADHPRLKELFEKFFSTQT---PPEEVPQM------MAD 191 Query: 253 ISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTS 312 + + K ++ ++ +P DL +L+ S +DG +TD+EI N L I+ G T+ Sbjct: 192 LGTLFTKIVEEKK----ANPGDDLTSALIAAS--EDGDHLTDEEILNTLQLIIAAGHETT 245 Query: 313 ASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRM 372 S + L P + + ++P I+ETLR Sbjct: 246 ISLIVNVVEALAIHPEQRKKVLS---------------------GEIPW-EGVIEETLRW 283 Query: 373 HMPL-HSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYF-DNPEDFDPTRWDTA 430 + P H + R T + + + ++PKG ++VS G E + DFD TR Sbjct: 284 NTPTSHVLIRFATEDIEV--GDKVLPKGEGLVVSFGALGRDEEQYGPTAGDFDATR---- 337 Query: 431 AAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYN 490 + ++ FG G H C G + ++ G L Sbjct: 338 -------------------------TPNRHIAFGHGPHVCPGAALSRLEAGIALPALYER 372 Query: 491 L 491 Sbjct: 373 F 373 >6A7I-A nrPDB Length = 411 Score = 146 bits (367), Expect = 3e-35, Method: Composition-based stats. Identities = 75/425 (17%), Positives = 131/425 (30%), Gaps = 90/425 (21%) Query: 80 GDVFSFMLLGKIMTVYLGPKGHEFVF---NAKLSDVSAEDAYKHLTTPVFGKGVIYDCPN 136 G + L G + + + + D+ +A++ P+ + P Sbjct: 26 GPLAEVELPGGVHVYAVTRHAEARALLTDSRVVKDIDVWNAWRRGEIPMDWPLIGLANPG 85 Query: 137 SRL--------MEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANV 188 + + ALT +R I + E A Sbjct: 86 RSMLTVDGADHRRLRTLVAQALTVKRVERLRAGIEALTNASLEKLAALPAGEPVDLKAEF 145 Query: 189 MKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDA 248 P I E+ + +L +K F+ P +P Sbjct: 146 AYPLPMNVI---------SELMGVDAADHPRLKELFEKFFSTQT---PPEEVPQM----- 188 Query: 249 AQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGG 308 + A + K + ++R +P DL +L+ S ++G +TD+EI N L I+ G Sbjct: 189 -MADLGALFTKIVDAKR----TNPGDDLTSALIAAS--ENGDHLTDEEIVNTLQLIIAAG 241 Query: 309 QHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKE 368 T+ S + L P + + L E G D I+E Sbjct: 242 HETTISLIVNVVEALQTHPEQRKKV------LNGEIGWD----------------GVIEE 279 Query: 369 TLRMHMPL-HSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYF-DNPEDFDPTR 426 TLR + P H + R T + + + I+PKG +++S G E + +FD TR Sbjct: 280 TLRWNTPTSHVLIRFATEDIEV--GDKILPKGEGLIISFGALGRDEEQYGPTAGEFDATR 337 Query: 427 WDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTT 486 + ++ FG G H C G + ++ G L Sbjct: 338 -----------------------------TPNRHIAFGHGPHVCPGAALSRLEAGIALPA 368 Query: 487 FVYNL 491 Sbjct: 369 LYERF 373 >5Z9I-A nrPDB Length = 398 Score = 143 bits (360), Expect = 2e-34, Method: Composition-based stats. Identities = 70/401 (17%), Positives = 123/401 (30%), Gaps = 73/401 (18%) Query: 94 VYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTT- 152 VY P+ + N K+ +G + + A T Sbjct: 38 VYGYPESAAILSNPKVFSSDTMRLDPIKLDEAIVEGDFAHTDPPKHRRLRGLVDHAFTPS 97 Query: 153 --DSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMR 210 + V I E+L+ F VA P I I ++ Sbjct: 98 LVAKMESRVHGIIHELLDGVEGKSQF------DLVAEFAAPLPLIMI---------SDLL 142 Query: 211 RIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDI 270 + + A +DK + + ++ R Sbjct: 143 GVPESDRALFRQWMDKMLDGSEKFESPETVLEQEEELHKELELLWEMRDYWHERAAESRK 202 Query: 271 DPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQ 330 P DLI L+ DG K+ D +I+N+ +L+ G T+A A +L L Sbjct: 203 RPREDLISQLVHAEV--DGQKLNDSQISNIANRLLVNGHLTTAMLIANTMLCLDAFSDQD 260 Query: 331 DVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIP 390 + D +P++ ++E++R P+ + R + + + Sbjct: 261 ARVRA-------------------DRSLVPAL---LEESMRYMSPICGVGRATNSEVEVA 298 Query: 391 ETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFG 450 T ++PK +LV G A+ ER F+ P+ FD R Sbjct: 299 GT--VIPKDQLLLVWTGAANRDERQFEKPDVFDAGR------------------------ 332 Query: 451 KVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL 491 + +L FG G H C+G Q A ++ + + L Sbjct: 333 -----SPNAHLGFGRGIHFCLGRQLARMESKAAVEILLDRL 368 >4WPZ-A nrPDB Length = 397 Score = 143 bits (359), Expect = 3e-34, Method: Composition-based stats. Identities = 77/390 (19%), Positives = 130/390 (33%), Gaps = 82/390 (21%) Query: 105 FNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIRE 164 F++K+ +A + T + + ++ +K A T + P+I E Sbjct: 57 FSSKVMATAAAAMSETETGKLMNESLV-GMDAPEHTRLRKLVTKAFTARRVETLRPRITE 115 Query: 165 EILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDL 224 + DE L V N P I GD+ D A + L Sbjct: 116 LVGQLL--DELETLPRPVDLVKNFSVPLPVRVICELLGVPAGDQ-----DTFHAWSNALL 168 Query: 225 DKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHS 284 ++AA + + + I +RE +P DLI L+ S Sbjct: 169 GDW-------------QQVVEKEAATVSLVNYFGELIAVKRE----NPADDLISELIAIS 211 Query: 285 TYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEK 344 +T++EI L IGIL G T+A+ + FL+ L P D + Sbjct: 212 DGD--STLTEREIIALSIGILSAGHETTANQISMFLVTLLHNPEELDKLR---------- 259 Query: 345 GGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLH---SIFRKVTNPLRIPETNYIVPKGHY 401 ++ + +P + E LR I R T + + ++P G Sbjct: 260 ---------DNREAIP---KAVDELLRFVPLTTTGGIIPRLTTAEVEL-SGGQVLPAGAV 306 Query: 402 VLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYL 461 VL + A+ F++ E + TR ++P+L Sbjct: 307 VLPAVATANRDPEVFEDGERLNVTR-----------------------------ENNPHL 337 Query: 462 PFGGGRHRCIGEQFAYVQLGTILTTFVYNL 491 FG G H C+G Q A ++L L + + Sbjct: 338 AFGAGIHHCLGAQLARIELQEALGAILDRM 367 >4YT3-A nrPDB Length = 410 Score = 142 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 66/395 (16%), Positives = 123/395 (31%), Gaps = 79/395 (20%) Query: 131 IYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMK 190 I + +++ A T S + + P+I+E + VA++ Sbjct: 88 ITESDPPDHRKRRSLLAAAFTPRSLQNWEPRIQEIADELIG---QMDGGTEIDIVASLAS 144 Query: 191 TQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQ 250 P I ++ + + +D F P + + A Sbjct: 145 PLPIIV---------MADLMGVPSKDRLLFKKWVDTLFLPFDR---EKQEEVDKLKQVAA 192 Query: 251 KKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQH 310 K+ + +R ++P D+I LL + DG TD E+ + IL G Sbjct: 193 KEYYQYLYPIVVQKR----LNPADDIISDLL--KSEVDGEMFTDDEVVRTTMLILGAGVE 246 Query: 311 TSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETL 370 T++ A L +YQE+ E L V ++E L Sbjct: 247 TTSHLLANSFYSLLYD---DKEVYQELHE------------------NLDLVPQAVEEML 285 Query: 371 RMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTA 430 R L + R V + + +G V+V A+ E F++P + R Sbjct: 286 RFRFNLIKLDRTVKEDNDLL--GVELKEGDSVVVWMSAANMDEEMFEDPFTLNIHR---- 339 Query: 431 AAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYN 490 + +L FG G H C+G A ++ LT F+ Sbjct: 340 ------------------------PNNKKHLTFGNGPHFCLGAPLARLEAKIALTAFLKK 375 Query: 491 LR-------WTIDGYKVPDPDYSSMVVLPTEPAEI 518 + + ++ ++ LP + + + Sbjct: 376 FKHIEAVPSFQLEENLTDSATGQTLTSLPLKASRM 410 >6GMF-A nrPDB Length = 397 Score = 142 bits (357), Expect = 4e-34, Method: Composition-based stats. Identities = 82/432 (18%), Positives = 127/432 (29%), Gaps = 87/432 (20%) Query: 66 QQPYEFFESCRQKYGDVFS-----FMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKH 120 + PY F R+ V FM +G+ V + N + Sbjct: 14 RNPYALFAELRRT-SAVGRLQPQGFMAVGRYQDVARVLHDAKGFSNRGWAASLPRGVKWD 72 Query: 121 LTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKE 180 + P I R + + A T + + P+IR+ + + K Sbjct: 73 TSMPP----SIVQVDPPRHGKLRTLVTKAFTPRTVAQLEPRIRDIAHELV---DGLRGKS 125 Query: 181 KTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPL 240 V P I I EM + A D + V Sbjct: 126 TFEATVEVTVPMPMIVI---------AEMLGVAPERRADFKRWSDDMVGSLALV------ 170 Query: 241 PHYWRRDAAQKKIS-ATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIAN 299 +AAQ + S + E +P DLI LL DG K+T E+ + Sbjct: 171 ---RVGNAAQLERSTQEFYAYFSEVLEERRREPREDLISQLLAAEV--DGEKLTAGEVLS 225 Query: 300 LLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKL 359 +L+ G T+ S L+ L + P DL + Sbjct: 226 FANTLLIAGNETTTSLIGNALVALTDHPEQLAAAQA-------------------DLSLV 266 Query: 360 PSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNP 419 P ++E LR P IFR+ + I + +P VL A+ E F +P Sbjct: 267 P---AVVEEVLRYESPAQCIFRQTMTDVEI--GDERIPARSVVLPLLASANRDESRFPDP 321 Query: 420 EDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQ 479 + FD R + +L FG H CIG A ++ Sbjct: 322 DRFDIHR-----------------------------DTKGHLAFGLDIHFCIGAPLARLE 352 Query: 480 LGTILTTFVYNL 491 +L + L Sbjct: 353 AKVMLEVLLARL 364 >1CPT-A nrPDB Length = 428 Score = 141 bits (354), Expect = 9e-34, Method: Composition-based stats. Identities = 70/439 (15%), Positives = 129/439 (29%), Gaps = 80/439 (18%) Query: 78 KYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNS 137 K+ DV GK ++ +G E +++ + + Sbjct: 56 KHADVMQI---GKQPGLFSNAEGSEILYDQNNEAFMRSISGGCPHVI----DSLTSMDPP 108 Query: 138 RLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQ----P 193 + S ++ IR F G + M P Sbjct: 109 THTAYRGLTLNWFQPASIRKLEENIRRIAQASVQRLLDF------DGECDFMTDCALYYP 162 Query: 194 EITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKI 253 + TA DE + Q + + + R Sbjct: 163 LHVVMTALGVPEDDEPLML---KLTQDFFGVHEPDEQAVAAPRQSADEAARRFHETIATF 219 Query: 254 SATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSA 313 + RR +D + SLL +S DG + D+ I + I G T++ Sbjct: 220 YDYFNGFTVDRRSC-----PKDDVMSLLANSKL-DGNYIDDKYINAYYVAIATAGHDTTS 273 Query: 314 STSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMH 373 S+S ++ L P L D +P + + E +R Sbjct: 274 SSSGGAIIGLSRNPEQLA-------------------LAKSDPALIPRL---VDEAVRWT 311 Query: 374 MPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAK 433 P+ S R + N + +G +++S A+ E F NP++FD TR+ Sbjct: 312 APVKSFMRTALADTEVRGQN--IKRGDRIMLSYPSANRDEEVFSNPDEFDITRF------ 363 Query: 434 ANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRW 493 + +L FG G H C+G+ A +++ + L+ Sbjct: 364 -----------------------PNRHLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLK- 399 Query: 494 TIDGYKVPDPDYSSMVVLP 512 +++ P ++ V P Sbjct: 400 SVELSGPPRLVATNFVGGP 418 >5XW2-A nrPDB Length = 419 Score = 141 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 76/423 (17%), Positives = 129/423 (30%), Gaps = 76/423 (17%) Query: 94 VYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTD 153 VY + E + + F +G + E +K A T Sbjct: 57 VYGYAEAIEVLGDPGTFSSHMSRLLPMGADEAFTEGDLLQTDPPDHRELRKLVSHAFTPK 116 Query: 154 SFKRYVPKIR---EEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMR 210 P+I +E+L+ ++F L V ++I +A R LF M Sbjct: 117 VVAELEPRITALTQELLDAVADRDTFDLMTALAYPLPVTVVAELLSIPSADRHLFEGWMT 176 Query: 211 RIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDI 270 I D+ P + R A ++ ++ Sbjct: 177 EIV-----HSLGDVSMEDAPEDQ----------ERIFEAGMAPMRKMLEYLREHAAECRR 221 Query: 271 DPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQ 330 P DL+ L+ DG ++TD I N +L+ G T+ +L L P Sbjct: 222 RPRGDLMGKLI--EAEVDGRRLTDNHIVNFAKMLLIAGYLTTTMLIGNTVLCLDSYPEQA 279 Query: 331 DVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIP 390 + D +P + ++E++R P+ + +R T + + Sbjct: 280 ARVRA-------------------DRSLIPGL---LEESMRFLSPVAATYRATTRDVEV- 316 Query: 391 ETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFG 450 + V+V G A+ R F PE FD TR Sbjct: 317 -AGQRLSADQMVMVWFGAANRDARQFAEPELFDMTR------------------------ 351 Query: 451 KVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVV 510 +P+L FG G H C+G A ++ L + + Y P+ + M Sbjct: 352 -----GPNPHLGFGRGIHFCLGGPLARMEGRVALDHLLDRF---PELYTDPERPPTFMPG 403 Query: 511 LPT 513 T Sbjct: 404 FDT 406 >5XNT-A nrPDB Length = 411 Score = 141 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 68/399 (17%), Positives = 123/399 (30%), Gaps = 79/399 (19%) Query: 123 TPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKT 182 V K I + +++ A T S + + P+I+E E + + Sbjct: 80 GSVPDKIKITEADPPEHRKRRSLLAAAFTPRSLQNWEPRIQEIADELI---EEMDEETEI 136 Query: 183 HGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPH 242 V ++ P I ++ + + +D F P + Sbjct: 137 DIVQSLASPLPIIV---------MSDLMGVPSKDRLLFKKWVDILFLPFDK---EKQEEV 184 Query: 243 YWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLI 302 + A K+ + +R ++P D+I LL DG TD E+ + Sbjct: 185 NELKQVAAKEYYQYLYPIVVQKR----LNPADDIISDLL--KAEVDGEMFTDDEVVRTTM 238 Query: 303 GILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSV 362 IL G T++ A L +YQE+ E L V Sbjct: 239 LILGAGVETTSHLLANSFYSLLYD---DKEVYQELHE------------------NLDLV 277 Query: 363 NNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDF 422 ++E LR L + R V + + +G V+V A+ E F++ Sbjct: 278 PQAVEEMLRYRFNLIKLDRTVKEDNDLL--GVELKEGENVVVWMSAANLDEEMFEDAFTL 335 Query: 423 DPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGT 482 + R + +L FG G H C+G A ++ Sbjct: 336 NIHR----------------------------PNNKKHLTFGNGPHFCLGAPLARLEAKI 367 Query: 483 ILTTFVYNLR-------WTIDGYKVPDPDYSSMVVLPTE 514 LTTF+ + + ++ ++ LP + Sbjct: 368 ALTTFLKKFKHIEAVPSFQLEDNLTDSATGQTLTSLPLK 406 >3R9C-A nrPDB Length = 418 Score = 135 bits (340), Expect = 4e-32, Method: Composition-based stats. Identities = 62/366 (16%), Positives = 99/366 (27%), Gaps = 72/366 (19%) Query: 127 GKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVA 186 G + A KR P+I + + + Sbjct: 93 GPASFLFLDPPDHTRLRGLVSKAFAPRVIKRLEPEITALVDQLLDAVDGPEFNLID---- 148 Query: 187 NVMKTQPEITIFTASRSLFGDEMR-RIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWR 245 N+ P I DE + A + +F W Sbjct: 149 NLAYPLPVAVICRLLGVPIEDEPKFSRASALLAAALDPFLALTGETSDLFDEQMKAGMWL 208 Query: 246 RDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGIL 305 RD I RR P DL+ L+ + + G ++T+ EI +L Sbjct: 209 RD--------YLRALIDERRRT----PGEDLMSGLV--AVEESGDQLTEDEIIATCNLLL 254 Query: 306 MGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNT 365 + G T+ + A L + P + + + Sbjct: 255 IAGHETTVNLIANAALAMLRTPGQWAALAADGSR----------------------ASAV 292 Query: 366 IKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPT 425 I+ET+R P+ + R + L I + VPKG +L+ AH P+ FDP Sbjct: 293 IEETMRYDPPVQLVSRYAGDDLTI--GTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDPD 350 Query: 426 RWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILT 485 R +L FG G H C+G A ++ L Sbjct: 351 R-----------------------------AQIRHLGFGKGAHFCLGAPLARLEATVALP 381 Query: 486 TFVYNL 491 Sbjct: 382 ALAARF 387 >2XKR-A nrPDB Length = 398 Score = 135 bits (339), Expect = 4e-32, Method: Composition-based stats. Identities = 75/387 (19%), Positives = 121/387 (31%), Gaps = 82/387 (21%) Query: 133 DCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQ 192 D + + ++K T K I ++ G + ++ Sbjct: 77 DMDDPAHLLRRKLVNAGFTRKRVKDKEASIA-------ALCDTLIDAVCERGECDFVRDL 129 Query: 193 PEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKK 252 ++ GD M + D T F+ ++ + A Sbjct: 130 AA----PLPMAVIGD-MLGVRPEQRDMFLRWSDDLVT---FLSSHVSQEDFQITMDAFAA 181 Query: 253 ISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTS 312 + I +RR DP DL+ L+ S+ DG +++D E+ + IL+GG T+ Sbjct: 182 YNDFTRATIAARR----ADPTDDLVSVLV--SSEVDGERLSDDELVMETLLILIGGDETT 235 Query: 313 ASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRM 372 T + L D DL D LP I+E LR Sbjct: 236 RHTLSGGTEQLLRNR-------------------DQWDLLQRDPSLLP---GAIEEMLRW 273 Query: 373 HMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAA 432 P+ ++ R +T T G +++ A+ E F PE FD R Sbjct: 274 TAPVKNMCRVLTADTEFHGTALC--AGEKMMLLFESANFDEAVFCEPEKFDVQR------ 325 Query: 433 KANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLR 492 + +L FG G H C+G Q A ++L + + L Sbjct: 326 -----------------------NPNSHLAFGFGTHFCLGNQLARLELSLMTERVLRRL- 361 Query: 493 WTIDGYKVPDPDYSSMVVLPTEPAEII 519 D V D VLP PA + Sbjct: 362 --PDLRLVADDS-----VLPLRPANFV 381 >6M7X-A nrPDB Length = 484 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 72/420 (17%), Positives = 143/420 (34%), Gaps = 60/420 (14%) Query: 77 QKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGK-------- 128 Q+ G +F + L G M + P+ E KL V + ++ P Sbjct: 50 QELGPIFRYDLGGAGMVCVMLPEDVE-----KLQQVDSLHPHRMSLEPWVAYRQHRGHKC 104 Query: 129 GVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLK-EKTHGVAN 187 GV + + L+ ++ +R++P + ++ + L+ + + Sbjct: 105 GVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLD 164 Query: 188 VMKTQPEITIFTASRSLFGDEMR------RIFDRSFAQLYSDLDKGFTPINFVFPNLPL- 240 V + TI ++ +LFG+ + +F + K + F+ +L Sbjct: 165 VQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRW 224 Query: 241 --PHYWRRD----AAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTD 294 P W+ + +++I ++ LL+++ ++ Sbjct: 225 TSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAE------LSP 278 Query: 295 QEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYE 354 I + + G T+ L L P++Q + QE + T E Sbjct: 279 DAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTE 338 Query: 355 DLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSER 414 LP + +KETLR++ + R ++ L + NY +P G V V + Sbjct: 339 ----LPLLRAALKETLRLYPVGLFLERVASSDLVL--QNYHIPAGTLVRVFLYSLGRNPA 392 Query: 415 YFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQ 474 F PE ++P RW G + ++PFG G +C+G + Sbjct: 393 LFPRPERYNPQRWLDIRGS---------------------GRNFYHVPFGFGMRQCLGRR 431 >1Z8P-A nrPDB Length = 404 Score = 133 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 58/381 (15%), Positives = 110/381 (28%), Gaps = 79/381 (20%) Query: 111 DVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYF 170 + A + F + +K T + P++ + Sbjct: 71 EFPAYLGFPEDVRNYFATNM-GTSDPPTHTRLRKLVSQEFTVRRVEAMRPRVEQITAELL 129 Query: 171 VTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTP 230 + GV +++ L G + F Sbjct: 130 D-------EVGDSGVVDIVDRFAHPLPIKVICELLGVD-------------EKYRGEFGR 169 Query: 231 INFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGV 290 + + +R A +++ + ++ RR P DL+ +L+ DG Sbjct: 170 WSSEILVMDPERAEQRGQAAREVVNFILDLVERRRTE----PGDDLLSALIRVQDDDDG- 224 Query: 291 KMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLND 350 +++ E+ ++ + +L+ G +S S L P ++ Sbjct: 225 RLSADELTSIALVLLLAGFESSVSLIGIGTYLLLTHPDQLALVR---------------- 268 Query: 351 LTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAH 410 D LP N ++E LR P + R + I +P+ VLV+ G A+ Sbjct: 269 ---RDPSALP---NAVEEILRYIAPPETTTRFAAEEVEI--GGVAIPQYSTVLVANGAAN 320 Query: 411 TSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRC 470 + F +P FD TR + +L FG G H C Sbjct: 321 RDPKQFPDPHRFDVTR-----------------------------DTRGHLSFGQGIHFC 351 Query: 471 IGEQFAYVQLGTILTTFVYNL 491 +G A ++ L Sbjct: 352 MGRPLAKLEGEVALRALFGRF 372 >6HQG-A nrPDB Length = 425 Score = 132 bits (331), Expect = 4e-31, Method: Composition-based stats. Identities = 84/462 (18%), Positives = 143/462 (30%), Gaps = 98/462 (21%) Query: 30 PFVYNLVWQYLYSLRKDRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLG 89 F + +W Y LRK+ +G P+E DV + + Sbjct: 31 LFRTDTMWPYFERLRKEDP-------------VHWGVSPHE----------DVGGYWSVT 67 Query: 90 KIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFA 149 K + HE VF+++ + V + A T P+F + Q+K + Sbjct: 68 KYNDIMAVDTNHE-VFSSEPTIVLPDPADDF-TLPMF-----IAMDPPKHDVQRKTVQPI 120 Query: 150 LTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEM 209 + + P IRE + V+ + T T+F Sbjct: 121 VAPNHLAYLEPIIRERAGKILDDLPIGEEINWVDKVSIELTTMTLATLFDFP-------- 172 Query: 210 RRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGD 269 DR +SD+ + P H R + +M+ R + Sbjct: 173 --WEDRRKLTFWSDVATSAPESGILGTTDPEEHENLRRQTLFECVDYFMRLWNER---VN 227 Query: 270 IDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHL 329 P DLI L + K+ +M E LI +++GG T+ +T + +L L + P Sbjct: 228 APPKPDLISMLAHGESTKNMDRM---EYLGNLILLIVGGNDTTRNTISGSVLALHQNPDQ 284 Query: 330 QDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRI 389 + E+ +P + ET+R PL + R+ + Sbjct: 285 DRKLR-------------------ENPGLIP---AMVSETIRWQTPLAYMRRRAKRDFEL 322 Query: 390 PETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGF 449 + +G V + + E D P D+ R Sbjct: 323 --GGKTIREGDKVAMWYVSGNRDEEVIDRPNDYWIER----------------------- 357 Query: 450 GKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL 491 +L FG G HRC+G + A +QL I + Sbjct: 358 -----PRVRQHLSFGFGVHRCVGNRLAELQLKIIWEEILARF 394 >4ZGX-A nrPDB Length = 489 Score = 131 bits (330), Expect = 6e-31, Method: Composition-based stats. Identities = 72/422 (17%), Positives = 143/422 (33%), Gaps = 54/422 (12%) Query: 72 FESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFV-----FNAKLSDVSAEDAYKHLTTPVF 126 Q+ G +F + L G M + P+ E + + + AY+ Sbjct: 45 MHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKC 104 Query: 127 GKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLK-EKTHGV 185 G V + + L+ + +R++P + ++ + L+ + Sbjct: 105 G--VFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLT 162 Query: 186 ANVMKTQPEITIFTASRSLFGDEMR------RIFDRSFAQLYSDLDKGFTPINFVFPNLP 239 +V + TI ++ +LFG+ + +F + K + F+ +L Sbjct: 163 LDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLS 222 Query: 240 L---PHYWRRD----AAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKM 292 P W+ + +++I ++ LL+ + + Sbjct: 223 RWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAE------L 276 Query: 293 TDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLT 352 + + I + + G T+A L L P +Q ++ QE + T Sbjct: 277 SLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKAT 336 Query: 353 YEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTS 412 E LP + +KETLR++ + R V++ L + NY +P G V V + Sbjct: 337 TE----LPLLRAALKETLRLYPVGLFLERVVSSDLVL--QNYHIPAGTLVQVFLYSLGRN 390 Query: 413 ERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIG 472 F PE ++P RW G + ++PFG G +C+G Sbjct: 391 AALFPRPERYNPQRWLDIRGS---------------------GRNFHHVPFGFGMRQCLG 429 Query: 473 EQ 474 + Sbjct: 430 RR 431 >6GK6-A nrPDB Length = 411 Score = 131 bits (328), Expect = 1e-30, Method: Composition-based stats. Identities = 61/387 (15%), Positives = 116/387 (29%), Gaps = 82/387 (21%) Query: 108 KLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEIL 167 KL D + F + D + + A + + P+I+E Sbjct: 68 KLPDEVRRRYFPLSDRTTFMDQHMLDADPPDHTRLRAIVQRAFSPRMMEGLRPRIQEIAD 127 Query: 168 NYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKG 227 + + +A+ P I L + Sbjct: 128 GLIDAVIDRR---RMELIADFAFPLPTAVI-----------------AELLGLPVEDRGR 167 Query: 228 FTPINFVF--PNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHST 285 F + P R ++ +A + +RR+ P DLI LL+ Sbjct: 168 FRRWTKILLAPAKDREFVERAQPVVEEFAAYFRALADARRKA----PRDDLISGLLLAEE 223 Query: 286 YKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKG 345 + K++ E+++++ +L+ G T+ A +L L P + + ++ Sbjct: 224 QE--HKLSPAELSSMVFLLLVAGHETTVHLIASGMLLLLSHPAERRRLDEDPG------- 274 Query: 346 GDLNDLTYEDLQKLPSVNNTIKETLRMHMPLH-SIFRKVTNPLRIPETNYIVPKGHYVLV 404 V + ++E LR P S R + + VP G V Sbjct: 275 ---------------LVGSAVEEALRCEGPAELSTIRWSLEDIELFGAR--VPAGEGVAA 317 Query: 405 SPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFG 464 A+ ++F +P+ FD R + ++ FG Sbjct: 318 GLLAANRDPQHFPDPDRFDIGR-----------------------------SPNRHIGFG 348 Query: 465 GGRHRCIGEQFAYVQLGTILTTFVYNL 491 GG H C+G A ++ +T + L Sbjct: 349 GGIHFCLGAMLARIEAAIAFSTLLRRL 375 >5LIE-A nrPDB Length = 414 Score = 130 bits (326), Expect = 2e-30, Method: Composition-based stats. Identities = 62/369 (16%), Positives = 116/369 (31%), Gaps = 74/369 (20%) Query: 124 PVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTH 183 PV G+ V+ + R ++ LT +R +R E + Sbjct: 89 PVAGQ-VLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEPGAPFDF-- 145 Query: 184 GVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHY 243 V++ E+ + L E R L+ ++ GF +P + Sbjct: 146 ----VVEIAAELPMQMICILLGVPETDRH------WLFEAVEPGFDFRGSRRATMPRLNV 195 Query: 244 WRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYK-DGVKMTDQEIANLLI 302 + A ++ ++ I +R P D++ + + D ++D E+ Sbjct: 196 ---EDAGSRLYTYALELIAGKRAE----PADDMLSVVANATIDDPDAPALSDAELYLFFH 248 Query: 303 GILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSV 362 + G T+ ++ A LL L E P + + + Sbjct: 249 LLFSAGAETTRNSIAGGLLALAENPDQLQTLRSDFE----------------------LL 286 Query: 363 NNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDF 422 I+E +R P S R + + + + G V+V G A+ FD ++F Sbjct: 287 PTAIEEIVRWTSPSPSKRRTASRAVSL--GGQPIEAGQKVVVWEGSANRDPSVFDRADEF 344 Query: 423 DPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGT 482 D TR +P+L FG G H C+G A ++L Sbjct: 345 DITR-----------------------------KPNPHLGFGQGVHYCLGANLARLELRV 375 Query: 483 ILTTFVYNL 491 + + Sbjct: 376 LFEELLSRF 384 >5FYF-A nrPDB Length = 470 Score = 130 bits (326), Expect = 2e-30, Method: Composition-based stats. Identities = 64/395 (16%), Positives = 120/395 (30%), Gaps = 71/395 (17%) Query: 102 EFVFNAKLSDVSAEDAYKHLTTPVFGKGV--IYDCPNSRLMEQKKFAKFALTTDSFKRYV 159 + +F K D+ + + L P G V + Q+ + + + K Sbjct: 113 DILFVDKSHDLFSAEPQIILGDPPEGLSVEMFIAMDPPKHDVQRSSVQGVVAPKNLKEME 172 Query: 160 PKIREEILNYFVTDES-FKLKEKTHGVANVMKTQ-PEITIFTASRSLFGDEMRRIFDRSF 217 IR + + + + + F E + Sbjct: 173 GLIRSRTGDVLDSLPTDKPFNWVPAVSKELTGRMLATLLDFPYEERHKLVEWSDRMAGAA 232 Query: 218 AQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLI 277 + + + DAA S + + K R +P DLI Sbjct: 233 SATGGEFADENAMFD--------------DAADMARSFSRLWRDKEARRAAGEEPGFDLI 278 Query: 278 DSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEV 337 L + KD + + I NL + +++GG T+ ++ + L+ + E P + + Sbjct: 279 SLLQSNKETKDLINRPMEFIGNLTL-LIVGGNDTTRNSMSGGLVAMNEFPREFEKLKA-- 335 Query: 338 VELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVP 397 K + N + E +R PL + R + + + Sbjct: 336 --------------------KPELIPNMVSEIIRWQTPLAYMRRIAKQDVEL--GGQTIK 373 Query: 398 KGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVS 457 KG V++ + ER FDNP+ F R D + Sbjct: 374 KGDRVVMWYASGNRDERKFDNPDQFIIDRKD----------------------------A 405 Query: 458 SPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLR 492 ++ FG G HRC+G + A +QL + + Sbjct: 406 RNHMSFGYGVHRCMGNRLAELQLRILWEEILKRFD 440 >6HQW-A nrPDB Length = 445 Score = 130 bits (326), Expect = 2e-30, Method: Composition-based stats. Identities = 64/368 (17%), Positives = 113/368 (30%), Gaps = 77/368 (20%) Query: 133 DCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVT-DESFKLKEKTHGVANVMKT 191 Q++ A T +IR + + + + Sbjct: 131 AMDRPDHTGQRRTVAPAFTPAKMVEMEAEIRRRTASVLDSLPWGERFDWVDKVSIELTTG 190 Query: 192 QPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQK 251 I DR +SD L R Sbjct: 191 MLAILFGF-----------PWADRRLLTFWSDWAGDVEL------TLARELADTRFGFLG 233 Query: 252 KISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHT 311 +++ + + +R P+ DLI S++IHS + M+ QE L+ +++GG T Sbjct: 234 EMAHYFQRLWGAR---MQAPPSGDLI-SMMIHSEAMN--HMSPQEFMGNLVLLIVGGNDT 287 Query: 312 SASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLR 371 + +T + + L + P D +L D +P N ++E +R Sbjct: 288 TRNTMSGIVHALDKFP-------------------DQRELLERDASLIP---NAVQECIR 325 Query: 372 MHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAA 431 PL + R T + + G V++ A+ E F+NP+ R Sbjct: 326 YVTPLAHMRRTATADTEL--FGNQIKAGEKVILWYISANRDETVFENPDKLMVDR----- 378 Query: 432 AKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTF-VYN 490 + +L FG G HRC+G + A +QL +L Sbjct: 379 -----------------------PNARRHLSFGHGIHRCVGARLAELQLRILLEEMHERR 415 Query: 491 LRWTIDGY 498 +R + G Sbjct: 416 MRVRVAGE 423 >4TRI-A nrPDB Length = 407 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 60/389 (15%), Positives = 115/389 (29%), Gaps = 75/389 (19%) Query: 127 GKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVA 186 G + D + + + ++K T V I ++ G Sbjct: 74 GMPYMIDMDDPQHLLRRKLVNAGFTRKRVMDKVDSI-------GRLCDTLIDAVCERGEC 126 Query: 187 NVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRR 246 + ++ ++ GD M + L D ++ ++ + Sbjct: 127 DFVRDIAA----PLPMAVIGD-MLGVLPTERDMLLKWSDDLVCGLSS---HVDEAAIQKL 178 Query: 247 DAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILM 306 + I RR P DL L+ +G +M+D EI + IL+ Sbjct: 179 MDTFAAYTEFTKDVITKRRAE----PTDDLFSVLVNSEV--EGQRMSDDEIVFETLLILI 232 Query: 307 GGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTI 366 GG T+ T + L D + +V + I Sbjct: 233 GGDETTRHTLSGGTEQLLRHRDQWDALVADVD----------------------LLPGAI 270 Query: 367 KETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTR 426 +E LR P+ ++ R +T T + G +++ A+ E F +P++F R Sbjct: 271 EEMLRWTSPVKNMCRTLTADTVFHGTE--LRAGEKIMLMFESANFDESVFGDPDNFRIDR 328 Query: 427 WDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTT 486 + ++ FG G H C+G Q A ++L + Sbjct: 329 -----------------------------NPNSHVAFGFGTHFCLGNQLARLELRLMTER 359 Query: 487 FVYNL-RWTIDGYKVPDPDYSSMVVLPTE 514 + L + ++ V P Sbjct: 360 VLRRLPDLRLADDAPVPLRPANFVSGPES 388 >1ODO-A nrPDB Length = 408 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 62/454 (13%), Positives = 130/454 (28%), Gaps = 102/454 (22%) Query: 80 GDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGV--------- 130 G +LG P + + + A + P FG+ V Sbjct: 28 GPATWVDVLGVQAWSVSDPVLLKQLLTSSDVSKDARAHW-----PAFGEVVGTWPLALWV 82 Query: 131 ----IYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVA 186 ++ + ++ A + P + + E Sbjct: 83 AVENMFTAYGPNHRKLRRLVAPAFSARRVDAMRPAVEAMVTGLVDRLAELPAGEPVDLRQ 142 Query: 187 NVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRR 246 + P I + D A + D Sbjct: 143 ELAYPLPIAVI-----GHLMGVPQDRRDGFRALVDGVFDTTLDQA-------------EA 184 Query: 247 DAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYK-DGVKMTDQEIANLLIGIL 305 A ++ + I ++R P D+ L+ + DG +++ +E+ + L+ ++ Sbjct: 185 QANTARLYEVLDQLIAAKRAT----PGDDMTSLLIAARDDEGDGDRLSPEELRDTLLLMI 240 Query: 306 MGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNT 365 G T+ + + L +P ++ + ++T+ D Sbjct: 241 SAGYETTVNVIDQAVHTLLTRPDQLALVRK-------------GEVTWAD---------V 278 Query: 366 IKETLRMHMPLHSIF-RKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDP 424 ++ETLR + + R + +P+ + +G +L S A+ + ++ + FD Sbjct: 279 VEETLRHEPAVKHLPLRYAVTDIALPDGR-TIARGEPILASYAAANRHPDWHEDADTFDA 337 Query: 425 TRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTIL 484 TR +L FG G H C+G A +++ L Sbjct: 338 TR-----------------------------TVKEHLAFGHGVHFCLGAPLARMEVTLAL 368 Query: 485 TTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEI 518 + ++ DP LP P+ I Sbjct: 369 ESLFGRF----PDLRLADPAEE----LPPVPSLI 394 >3RWL-A nrPDB Length = 426 Score = 128 bits (320), Expect = 7e-30, Method: Composition-based stats. Identities = 58/360 (16%), Positives = 108/360 (30%), Gaps = 74/360 (20%) Query: 133 DCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQ 192 R EQ+K + + IRE + + + V+ + TQ Sbjct: 113 AMDRPRHDEQRKAVSPIVAPANLAALEGTIRERVSKTLDGLPVGEEFDWVDRVSIEITTQ 172 Query: 193 PEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKK 252 T+F ++ R D + A + + + +R + Sbjct: 173 MLATLFDFP-FEERRKLTRWSDVTTAAPGGGVVESWD---------------QRKTELLE 216 Query: 253 ISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTS 312 +A + R + DP DLI L ++ MT +E ++ +++GG T+ Sbjct: 217 CAAYFQVLWNER---VNKDPGNDLISMLAHSPATRN---MTPEEYLGNVLLLIVGGNDTT 270 Query: 313 ASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRM 372 ++ +L L + P + V + E +R Sbjct: 271 RNSMTGGVLALHKNPDQFAKLKANPA----------------------LVETMVPEIIRW 308 Query: 373 HMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAA 432 PL + R + + KG V++ + + D PE+F R Sbjct: 309 QTPLAHMRRTAIADSEL--GGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDR------ 360 Query: 433 KANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLR 492 +L FG G HRC+G + A +QL + + Sbjct: 361 ----------------------PRPRQHLSFGFGIHRCVGNRLAEMQLRILWEEILTRFS 398 >4YZR-A nrPDB Length = 405 Score = 126 bits (315), Expect = 3e-29, Method: Composition-based stats. Identities = 62/446 (13%), Positives = 132/446 (29%), Gaps = 95/446 (21%) Query: 60 SAASYGQQPYEFFESCR----------QKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKL 109 + P+ R +++G + L+ + K + + K Sbjct: 9 HGKEFHHNPFSVLGRFREEEPIHRFELKRFGATYPAWLITRYDDCMAFLKDNRITRDVKN 68 Query: 110 SDVSAEDAYKHLTTPV-FGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILN 168 + +++ + F + + A T + + I + Sbjct: 69 VMNQEQIKMLNVSEDIDFVSDHMLAKDTPDHTRLRSLVHQAFTPRTIENLRGSIEQIAEQ 128 Query: 169 YFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFG--DEMRRIFDRSFAQLYSDLDK 226 E A++MK+ F L G E R F + + D + Sbjct: 129 LLDEMEK-------ENKADIMKSFASPLPFIVISELMGIPKEDRSQF-QIWTNAMVDTSE 180 Query: 227 GFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTY 286 G + + A ++ K I RR I P DLI L+ Sbjct: 181 GNRELT--------------NQALREFKDYIAKLIHDRR----IKPKDDLISKLVHA--E 220 Query: 287 KDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGG 346 ++G K++++E+ ++L +++ G T+ + L L + + + Q+ + Sbjct: 221 ENGSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIAT---- 276 Query: 347 DLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIF-RKVTNPLRIPETNYIVPKGHYVLVS 405 ++E LR P+ + R + + +G + + Sbjct: 277 ------------------AVEELLRYTSPVVMMANRWAIED--FTYKGHSIKRGDMIFIG 316 Query: 406 PGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGG 465 G A+ +F+NPE + R + ++ FG Sbjct: 317 IGSANRDPNFFENPEILNINR-----------------------------SPNRHISFGF 347 Query: 466 GRHRCIGEQFAYVQLGTILTTFVYNL 491 G H C+G A ++ + Sbjct: 348 GIHFCLGAPLARLEGHIAFKALLKRF 373 >4JBT-A nrPDB Length = 410 Score = 125 bits (314), Expect = 4e-29, Method: Composition-based stats. Identities = 64/424 (15%), Positives = 122/424 (28%), Gaps = 87/424 (20%) Query: 80 GDVFSFMLLGKI-MTVYLGPKGHEFVFNAKL-SDVSAEDAYKHLTT----PVFGKGVI-- 131 G + LLG + V + + + +L D++A ++ T P+ G + Sbjct: 30 GPLTRIDLLGVPALAVTGHTLARQLLTDTRLVKDINAWSLWQSGTVTRQWPLIGMIDVDR 89 Query: 132 --YDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVM 189 + + ALT P I + E + +V Sbjct: 90 SMFTVDGPEHRRLRIKTTQALTRRRLDALKPTIERYVAELLDDLERAGADGAVVDLKSVF 149 Query: 190 KTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAA 249 + + +A + ++ Y TP Sbjct: 150 AYPLPMRVISALMGVPSED-----QEQLLTWYKAFFSILTP----------------QDE 188 Query: 250 QKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQ 309 + ++ R +P DL +L+ + + +T++E+ L ++ G Sbjct: 189 RLRVIDEMHGYFTEMVRRKTAEPGDDLTSALIYATDGE--TPLTEEEVIGNLQALVAAGH 246 Query: 310 HTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKET 369 T+ S + L P ++ E G I+ET Sbjct: 247 ETTVSLILTAVRALLSHPEQLRLVRD------GEIGW----------------ETAIEET 284 Query: 370 LRMHMPL-HSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYF-DNPEDFDPTRW 427 LR P+ H + R T I + ++P+G V++S + +DFD TR Sbjct: 285 LRWDGPVIHLLMRFATED--IDLGDAVIPRGEGVVMSYRAIGRDITVHGADADDFDITR- 341 Query: 428 DTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTF 487 ++ ++ FG G H C G A ++ L Sbjct: 342 ---------------------------ATAARHISFGHGPHICPGAALARLEAAIALPAL 374 Query: 488 VYNL 491 Sbjct: 375 FTRF 378 >2Y5N-A nrPDB Length = 417 Score = 125 bits (314), Expect = 4e-29, Method: Composition-based stats. Identities = 71/435 (16%), Positives = 130/435 (29%), Gaps = 100/435 (22%) Query: 79 YGDVFSFMLLGKI--------MTVYLGPKGHEFVFNAKLSDVSAEDAYKH---------- 120 + DV L G+ ++ P G E + DV A Sbjct: 31 FNDVHGLTLAGRYGELQETEPVSRVRPPYGEEAWLVTRYEDVRAVLGDGRFVRGPSMTRD 90 Query: 121 --LTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKL 178 T P KG + ++ A T + P+ RE + Sbjct: 91 EPRTRPEMVKGGLLSMDPPEHSRLRRLVVKAFTARRAESLRPRAREIAHELV---DQMAA 147 Query: 179 KEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNL 238 + + + Q + + + + R FT + F + Sbjct: 148 TGQPADLVAMFARQLPVRVICELLGVPSADHDR----------------FTRWSGAFLST 191 Query: 239 PLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIA 298 A ++ A I RR+ P DL+ +L+ +D +++QE+ Sbjct: 192 AEVTAEEMQEAAEQAYAYMGDLIDRRRKE----PTDDLVSALVQARDQQDS--LSEQELL 245 Query: 299 NLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQK 358 +L IG+L+ G ++ + A F+ L +P L+ + L + Sbjct: 246 DLAIGLLVAGYESTTTQIADFVYLLMTRPELRRQL----------------------LDR 283 Query: 359 LPSVNNTIKETLRMHM--PLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYF 416 + + ++E R + R + + + G VL S G A+ + F Sbjct: 284 PELIPSAVEELTRWVPLGVGTAFPRYAVEDVTL--RGVTIRAGEPVLASTGAANRDQAQF 341 Query: 417 DNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFA 476 + + D R + +L FG G H C+G A Sbjct: 342 PDADRIDVDR-----------------------------TPNQHLGFGHGVHHCLGAPLA 372 Query: 477 YVQLGTILTTFVYNL 491 V+L L + L Sbjct: 373 RVELQVALEVLLQRL 387 >3WVS-A nrPDB Length = 401 Score = 125 bits (313), Expect = 5e-29, Method: Composition-based stats. Identities = 64/364 (17%), Positives = 118/364 (32%), Gaps = 84/364 (23%) Query: 132 YDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKT 191 ++ ++ A T + PK+ + D+ E VA+ Sbjct: 91 FNMDAPDHTRLRRLISKAFTIRRVEELRPKVHDLAHRLI--DDMLAKGEPADLVADYALP 148 Query: 192 QPEITIFTASRSLFGD--EMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAA 249 P I F D + R D + + ++G Sbjct: 149 IPTTVICELLGVPFEDREKFGRWTDAILSTSTLNPEEG-------------------RVK 189 Query: 250 QKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQ 309 + ++ I +RR P DLI ++ +D K+T+QE+ + IG+L+ G Sbjct: 190 RMELVGYIGGIIAARR----AQPADDLISGMIEARDVQD--KLTEQELLDHCIGLLIAGH 243 Query: 310 HTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKET 369 T+AS F+ L ++P + +D + +P + ++E Sbjct: 244 ETTASQIPSFVYALLDQPQHWKRL-------------------LDDPELIP---SAVEEL 281 Query: 370 LRMHM--PLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRW 427 R + R + + +V G VLV+ G A+ F++PE+ R Sbjct: 282 FRFVPLGSGSAAPRYAREDIEV--GGTLVRAGEPVLVALGAANRDGLRFEDPEEIKLDR- 338 Query: 428 DTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTF 487 S+ ++ FG G H C+G A ++L L Sbjct: 339 ----------------------------PSNHHIGFGHGIHHCLGAPLARLELQEALRAL 370 Query: 488 VYNL 491 + L Sbjct: 371 LERL 374 >2WM5-A nrPDB Length = 435 Score = 124 bits (312), Expect = 8e-29, Method: Composition-based stats. Identities = 60/367 (16%), Positives = 113/367 (30%), Gaps = 74/367 (20%) Query: 126 FGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGV 185 FG ++ D + R + A T R +R+ + + + V Sbjct: 114 FGSMIVLD--DPRHQRLRSIVSRAFTPKVVARIEAAVRDRAHRLVSSMIANNPDRQADLV 171 Query: 186 ANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWR 245 + + P I +M I +++ V P Sbjct: 172 SELAGPLPLQIIC---------DMMGIPKADHQRIFH--------WTNVILGFGDPDLAT 214 Query: 246 RDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGIL 305 ++SA + E ++ + DL SL+ DG +++ +EIA+ I ++ Sbjct: 215 DFDEFMQVSADIGAYATALAEDRRVNHHDDLTSSLV--EAEVDGERLSSREIASFFILLV 272 Query: 306 MGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNT 365 + G T+ + +L L P +D + + L Sbjct: 273 VAGNETTRNAITHGVLALSRYPEQRDRWWSDFDGL---------------------APTA 311 Query: 366 IKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPT 425 ++E +R P+ + R +T + + T G V + A+ E F +P FD Sbjct: 312 VEEIVRWASPVVYMRRTLTQDIELRGTKMA--AGDKVSLWYCSANRDESKFADPWTFDLA 369 Query: 426 RWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPF-GGGRHRCIGEQFAYVQLGTIL 484 R +P+L F GGG H C+G A ++ Sbjct: 370 R-----------------------------NPNPHLGFGGGGAHFCLGANLARREIRVAF 400 Query: 485 TTFVYNL 491 + Sbjct: 401 DELRRQM 407 >5EX6-C nrPDB Length = 434 Score = 124 bits (311), Expect = 8e-29, Method: Composition-based stats. Identities = 56/391 (14%), Positives = 112/391 (28%), Gaps = 86/391 (21%) Query: 129 GVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANV 188 G + D ++ T +R P I + + + + + + + Sbjct: 122 GNLMDYDPPEHTRLRRLLAPGFTHRKIRRMAPYIEQIVTERL---DEMEREGSPADLIEL 178 Query: 189 MKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDA 248 + + + D+ L + L RR A Sbjct: 179 FADEVPGPVLCELLGVPRDDRAMFLQLCHRHLDASLSG-----------------RRRAA 221 Query: 249 AQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGG 308 A + S + + R+ DP LI ++ + G +TD+E+ + + +++ G Sbjct: 222 AGEAFSRYLVTMVARERK----DPGDGLIGMVVA----EHGDTVTDEELRGVCVQMMLAG 273 Query: 309 QHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKE 368 + +L L P + +P+ + E Sbjct: 274 DDNISGMIGLGVLALLRNPEQIAAL----------------------RGDVPAAERAVDE 311 Query: 369 TLRM-HMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRW 427 +R +P R + + ++ G VL S A+ + + D TR Sbjct: 312 LIRYLTVPYAPTPRTAIEDSTV--GDQVIKAGETVLCSLPTANRDPALLPDADRLDVTR- 368 Query: 428 DTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTF 487 + P++ FG G H C+G A ++L T Sbjct: 369 ----------------------------EAVPHVAFGHGVHHCLGAALARLELRIAYTAL 400 Query: 488 VYNLRWTIDGYKVPDPDYSSMVVLPTEPAEI 518 ++ DPD ++ L T I Sbjct: 401 WRRF----PDLRLADPDGATEFRLSTPAYGI 427 >4Z5P-A nrPDB Length = 400 Score = 124 bits (311), Expect = 9e-29, Method: Composition-based stats. Identities = 64/420 (15%), Positives = 118/420 (28%), Gaps = 95/420 (22%) Query: 98 PKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCP------------NSRLMEQKKF 145 P G E + DV A ++ + G+ P ++ Sbjct: 41 PYGGEGWMVTRYDDVRAANSDPRFSRAQIGEDTPRTTPLARRSDTILSLDPPEHTRLRRL 100 Query: 146 AKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLF 205 A T + E E A++++ + L Sbjct: 101 LSKAFTARRMGAMQSWLEELFAGLLDGVERTGHP------ADIVRDLAQPFTIAVICRLL 154 Query: 206 GDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRR 265 G F + V + +A I A + +RR Sbjct: 155 GVPYEDR-------------GRFQHWSEVIMSTTAYSKEEAVSADASIRAYLADLVSARR 201 Query: 266 ERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGE 325 P+ DL+ L+ S D ++T+ E+ + +L+ G TSA + L Sbjct: 202 AA----PHDDLLGVLV--SARDDDDRLTEDELITFGVTLLVAGHETSAHQLGNMVYALLT 255 Query: 326 KPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSI--FRKV 383 ++ ++ + ++E LR + + R Sbjct: 256 HEDQLSLLREQPE----------------------LLPRAVEELLRFVPLGNGVGNARIA 293 Query: 384 TNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSD 443 + + V G V+ + A+ R FD+P+ D TR Sbjct: 294 LEDVELSGG--TVRAGEGVVAAAVNANRDPRAFDDPDRLDITR----------------- 334 Query: 444 EVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL---RWTIDGYKV 500 +P+L FG G H C+G Q A ++L + + R + +V Sbjct: 335 ------------EKNPHLAFGHGAHYCLGAQLARMELRVAIGGLLERFPGLRLAVPADQV 382 >3A50-A nrPDB Length = 411 Score = 124 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 53/354 (14%), Positives = 104/354 (29%), Gaps = 79/354 (22%) Query: 135 PNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPE 194 +K + T P+I E T G ++M+ Sbjct: 91 DPPDHTRLRKLVGRSFTVRRMNELEPRITEIADGLLAGLP-------TDGPVDLMREYAF 143 Query: 195 ITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKIS 254 L G L ++ F+ + V + ++AA K+ Sbjct: 144 QIPVQVICELLG-------------LPAEDRDDFSAWSSVLVDDSPAD--DKNAAMGKLH 188 Query: 255 ATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSAS 314 ++ +R D + S L+ + DG +++ +E+ + + +L+ G T+ + Sbjct: 189 GYLSDLLERKRTE-----PDDALLSSLLAVSDMDGDRLSQEELVAMAMLLLIAGHETTVN 243 Query: 315 TSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHM 374 +L L P Q + E L+ ++E LR Sbjct: 244 LIGNGVLALLTHPD-QRKLLAEDPSLISS---------------------AVEEFLRFDS 281 Query: 375 PLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKA 434 P+ + T + + +P G V++ A+ + P+ D TR + Sbjct: 282 PVSQAPIRFTAE-DVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDASGGVF- 339 Query: 435 NSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFV 488 FG G H C+G Q A ++ + Sbjct: 340 ----------------------------FGHGIHFCLGAQLARLEGRVAIGRLF 365 >4XE3-A nrPDB Length = 407 Score = 124 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 66/469 (14%), Positives = 129/469 (27%), Gaps = 88/469 (18%) Query: 46 DRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVF 105 D P + +P A P+ + V G V + Sbjct: 12 DAVPAYPFSLP---HALDL--DPHYAELRRDEPVSRVRLPYGEGTAWLVTRMSDARIVLG 66 Query: 106 NAKLSDVSAEDAYKHLTTP-VFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIRE 164 +++ S +A D P + ++ A T + P++R Sbjct: 67 DSRFSTAAATDPATPRMFPTPPEPDGVLAQDPPDHTRLRRLVGKAFTARRVEEMRPRVRS 126 Query: 165 EILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDL 224 + + + + + + + + ++ Sbjct: 127 LVDSLL---DDMVAHGSPADLVEFLAVPFPVAVICELLGVPLED---------------- 167 Query: 225 DKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHS 284 F + + Q+ + RR+ P DL+ +L + + Sbjct: 168 RDLFRTFSDAMLSSTRLTAAEIQRVQQDFMVYMDGLVAQRRDA----PTEDLLGALALAT 223 Query: 285 TYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEK 344 D +T EI N+ + +L+ G TS + + L Sbjct: 224 DNDD--HLTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLT------------------- 262 Query: 345 GGDLNDLTYEDLQKLPSV-NNTIKETLRMHMPLH--SIFRKVTNPLRIPETNYIVPKGHY 401 YE L P++ ++E LR + S R T + + + V G Sbjct: 263 ----ERKRYESLVADPALVPAAVEEMLRYTPLVSAGSFVRVATEDVEL--STVTVRAGEP 316 Query: 402 VLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYL 461 +V A+ E FD+ ++ D R +P++ Sbjct: 317 CVVHFASANRDEEVFDHADELDFHR-----------------------------ERNPHI 347 Query: 462 PFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVV 510 FG G H CIG Q ++L L+ V V + ++ Sbjct: 348 AFGHGAHHCIGAQLGRLELQEALSALVRRFPTLDLAEPVAGLKWKQGML 396 >1GWI-A nrPDB Length = 411 Score = 124 bits (310), Expect = 1e-28, Method: Composition-based stats. Identities = 62/361 (17%), Positives = 109/361 (30%), Gaps = 80/361 (22%) Query: 133 DCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQ 192 + + ALT + +I E + GV ++ Sbjct: 94 TVDGAEHRRLRTLVAQALTVRRVEHMRGRITELTDRLLDELPA------DGGVVDLKAAF 147 Query: 193 PEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKK 252 L G E R+ L+ TP V L + Sbjct: 148 AYPLPMYVVADLMGIEEARL--PRLKVLFEKFFSTQTPPEEVVATLT------------E 193 Query: 253 ISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTS 312 +++ + ++R P DL +L+ S ++G +TD EI + L ++ G T+ Sbjct: 194 LASIMTDTVAAKRAA----PGDDLTSALIQAS--ENGDHLTDAEIVSTLQLMVAAGHETT 247 Query: 313 ASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRM 372 S +++L P E L+ + + ++ETLR Sbjct: 248 ISLIVNAVVNLSTHP--------EQRALVLSGEAEWS--------------AVVEETLRF 285 Query: 373 HMPL-HSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYF-DNPEDFDPTRWDTA 430 P H + R +P + ++P G ++VS G ER + FD TR Sbjct: 286 STPTSHVLIRFAAED--VPVGDRVIPAGDALIVSYGALGRDERAHGPTADRFDLTR---- 339 Query: 431 AAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYN 490 + ++ FG G H C G + ++ G L Sbjct: 340 ------------------------TSGNRHISFGHGPHVCPGAALSRMEAGVALPALYAR 375 Query: 491 L 491 Sbjct: 376 F 376 >5NWS-A nrPDB Length = 435 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 60/387 (15%), Positives = 112/387 (28%), Gaps = 74/387 (19%) Query: 124 PVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTH 183 V+ G I D ++ A P I +E+ Sbjct: 108 RVYLLGSILDSDPPDHPRLRRLVTRAFAARRILGLRPGIERIADRLLAELPR---REEED 164 Query: 184 GVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHY 243 G ++++ T L G + + + + + Sbjct: 165 GTVDLLEHFAYPLSITVICELVGIPATDL------ERWREWGGDLVSMRP---------- 208 Query: 244 WRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIG 303 R + + + I+ RR D + S LI + DG +++D E +++ Sbjct: 209 ERLRHSFPVMIDYCHRLIEQRRAALT-----DDLLSELIRAQDDDGGRLSDIETVTMILT 263 Query: 304 ILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVN 363 +++ G TSA L P L +D LP Sbjct: 264 LVLAGHETSAHLIGNGTAALLTHP-------------------GQWALLRKDPALLP--- 301 Query: 364 NTIKETLRMHMPLH-SIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDF 422 + E +R +H + R T L + T V +G V + A+ R++ +P+ Sbjct: 302 RAVHELMRWCGSVHVARLRYATEDLELAGT--PVARGDAVQLVLVSANFDPRHYSDPDRL 359 Query: 423 DPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGT 482 D TR +G + ++ FG G H C+G A + Sbjct: 360 DITR-------------------------HQEGQAENHVGFGHGIHYCLGATLARQEGEV 394 Query: 483 ILTTFVYNLRWTIDGYKVPDPDYSSMV 509 L + P+ + + Sbjct: 395 ALARLLETYPDLALADGDPEVRRARLP 421 >3ABB-A nrPDB Length = 408 Score = 123 bits (308), Expect = 2e-28, Method: Composition-based stats. Identities = 61/415 (14%), Positives = 128/415 (30%), Gaps = 87/415 (20%) Query: 94 VYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGVIY----DCPNSRLMEQKKFAKFA 149 + +G + + +LS + + +G + + Q++ + Sbjct: 53 ITGHAEGRALLVDPRLSSDWGHPDFPVVVRRTEDRGGLAFPLIGVDDPVHARQRRMLIPS 112 Query: 150 LTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEM 209 P+++ + D+ V+ P + I +GD Sbjct: 113 FGVKRMNAIRPRLQSLVDRLL--DDMLAKGPGADLVSAFALPVPSVAICELLGVPYGDH- 169 Query: 210 RRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGD 269 + + + F A TY+ + R++ Sbjct: 170 ---------DFFEECSRNFV----------GAATSAEADAAFGELYTYLHGLVGRKQ--- 207 Query: 270 IDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHL 329 +P L+D L+ + + E+ + + +L+ G T+ + A L L + P Sbjct: 208 AEPEDGLLDELIARQLEEG--DLDHDEVVMIALVLLVAGHETTVNAIALGALTLIQHP-- 263 Query: 330 QDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRI 389 +++ LL++ G +V+ ++E LR I R + + Sbjct: 264 -----EQIDVLLRDPG---------------AVSGVVEELLRFTSVSDHIVRMAKEDIEV 303 Query: 390 PETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGF 449 + G VLVS + + ++NP+ FD R Sbjct: 304 --GGATIKAGDAVLVSITLMNRDAKAYENPDIFDARR----------------------- 338 Query: 450 GKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYN---LRWTIDGYKVP 501 + ++ FG G H+C+G+ A +L L LR + +VP Sbjct: 339 ------NARHHVGFGHGIHQCLGQNLARAELEIALGGLFARIPGLRLAVPLDEVP 387 >4UBS-A nrPDB Length = 393 Score = 122 bits (306), Expect = 3e-28, Method: Composition-based stats. Identities = 56/385 (14%), Positives = 108/385 (28%), Gaps = 86/385 (22%) Query: 135 PNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPE 194 + Q++ + T P+I+E + E+ V+ P Sbjct: 87 DDPEHRTQRRMLVPSFTLKRAAALRPRIQETVDGLLDAMEAQGPPA--ELVSAFALPLPS 144 Query: 195 ITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKIS 254 + I Y+D D + + P A+ ++ Sbjct: 145 MVI----------------CALLGVPYADHDFFESQSRRLLRG---PGIAEVQDARAQLD 185 Query: 255 ATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSAS 314 I +R+ P L+D L+ + + E+ +L +L+ G T+A+ Sbjct: 186 DYLYALIDRKRKE----PGDGLLDDLIQEQLNRG--TVDRAELVSLATLLLIAGHETTAN 239 Query: 315 TSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHM 374 + L P + E +P ++E LR Sbjct: 240 MISLGTFTLLRHPEQLAELRAE-------------------PGLMP---AAVEELLRFLS 277 Query: 375 PLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKA 434 + R T + + T + V+ + + F P+ D R Sbjct: 278 IADGLLRVATEDIEVAGT--TIRADEGVVFATSVINRDAAGFAEPDALDWHR-------- 327 Query: 435 NSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYN---L 491 + ++ FG G H+C+G+ A ++ L T L Sbjct: 328 ---------------------SARHHVAFGFGIHQCLGQNLARAEMEIALGTLFERLPGL 366 Query: 492 RWTIDGYKV---PDPDYSSMVVLPT 513 R ++ P M+ LP Sbjct: 367 RLAAPADEIPFKPGDTIQGMLELPV 391 >1WIY-A nrPDB Length = 389 Score = 122 bits (305), Expect = 4e-28, Method: Composition-based stats. Identities = 76/457 (16%), Positives = 142/457 (31%), Gaps = 88/457 (19%) Query: 63 SYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLT 122 Q P + + +F L + + P+G E A+ + + Y+ L+ Sbjct: 15 DLQQDPLAVLLEWGRAHPRLF-LPLPRFPLALIFDPEGVEGALLAEGTTKATF-QYRALS 72 Query: 123 TPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKT 182 + G+G++ D S E +K K S + Y + EE +F ++ +E+ Sbjct: 73 -RLTGRGLLTDWGKS-WKEARKALKDPFLPKSVRGYREAMEEEAWAFFG---EWRGEER- 126 Query: 183 HGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPH 242 ++ +++ R+LFG + + + + Sbjct: 127 ----DLDHEMLALSLRLLGRALFGKPLSPSLAEHALKALDRIMAQTRSPLALLDLAAEAR 182 Query: 243 YWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLI 302 + + A + E + P + + + + Sbjct: 183 FRKDRGA-----------LYREAEALIVHPP---------------LSHLPRERALSEAV 216 Query: 303 GILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSV 362 +L+ G T AS W L L +P Q + + L Sbjct: 217 TLLVAGHETVASALTWSFLLLSHRPDWQKRVAESEEAALAA------------------- 257 Query: 363 NNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDF 422 +E LR++ P + R++ PL + E +P+G +++SP YF E F Sbjct: 258 ---FQEALRLYPPAWILTRRLERPLLLGEDR--LPQGTTLVLSPYVTQRL--YFPEGEAF 310 Query: 423 DPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGT 482 P R+ S Y PFG G+ C+G FA ++ Sbjct: 311 QPERFLAERGTP----------------------SGRYFPFGLGQRLCLGRDFALLEGPI 348 Query: 483 ILTTFVYNLRWTIDGYK--VPDPDYSSMVVLPTEPAE 517 +L F R + + LP P E Sbjct: 349 VLRAFFRRFRLDPLPFPRVLAQVTLRPEGGLPARPRE 385 >3MGX-A nrPDB Length = 415 Score = 121 bits (304), Expect = 6e-28, Method: Composition-based stats. Identities = 55/366 (15%), Positives = 114/366 (31%), Gaps = 82/366 (22%) Query: 136 NSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEI 195 + + + +K L+ + ++ ++R E+ + ++ + + + Sbjct: 111 HEQHRKLRKLVGPLLSRAAARKLAERVRIEVGDVLGRVLDGEVCDAATAIGPRIPAAVVC 170 Query: 196 TIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISA 255 I ++M +L G TP A +I Sbjct: 171 EILGVPA--EDEDMLIDLTNHAFGGEDELFDGMTP----------------RQAHTEILV 212 Query: 256 TYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSAST 315 + + I +RR+ P DL+ +L+ +T ++ +L+GG T+ Sbjct: 213 YFDELITARRKE----PGDDLVSTLVTD------DDLTIDDVLLNCDNVLIGGNETTRHA 262 Query: 316 SAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMP 375 + L P L + ++ + ++E LR P Sbjct: 263 ITGAVHALATVPGLLTALRDGSADV----------------------DTVVEEVLRWTSP 300 Query: 376 LHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKAN 435 + R T + I + +P G V+ A+ FD+P+ F P R Sbjct: 301 AMHVLRVTTADVTINGRD--LPSGTPVVAWLPAANRDPAEFDDPDTFLPGR--------- 349 Query: 436 SVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTI 495 + ++ FG G H C+G A ++L +L + + Sbjct: 350 --------------------KPNRHITFGHGMHHCLGSALARIELSVVLRVLAERVS-RV 388 Query: 496 DGYKVP 501 D + P Sbjct: 389 DLEREP 394 >5IT1-A nrPDB Length = 399 Score = 121 bits (303), Expect = 7e-28, Method: Composition-based stats. Identities = 67/400 (16%), Positives = 127/400 (31%), Gaps = 80/400 (20%) Query: 113 SAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVT 172 A + T G+G + + +K T + P I+ + + Sbjct: 69 HALHTQDGVVTQKPGRGSLLWQDAPEHTDDRKLLAKEFTVRRMQALRPNIQRIVDEHLDA 128 Query: 173 DESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPIN 232 E+ G +++KT LFG R + + ++ + ++ Sbjct: 129 IEARG------GPVDLVKTFANPVPSMVISDLFGVPAERRAE------FQEIAEAMMRVD 176 Query: 233 FVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKM 292 +AA ++ + ++ RR +P DLI +L+ + DGV + Sbjct: 177 Q--------DAAATEAAGMRLGGLLYQLVQERR----ANPGDDLISALIT-TEDPDGV-I 222 Query: 293 TDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLT 352 D + N +L+ T+A L ++P ++ ++ Sbjct: 223 DDMFLMNAAGTLLIAAHDTTACMIGLGTALLLDRPDQLALLQKDPS-------------- 268 Query: 353 YEDLQKLPSVNNTIKETLRMHMPLH-SIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHT 411 + N ++E LR R T I + KG V+ A Sbjct: 269 --------LIGNAVEELLRYLTIGQFGAERVATQDGEI--GGVRIAKGEQVVTHLLSADF 318 Query: 412 SERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCI 471 + ++PE FD TR +P+L FG G H+CI Sbjct: 319 DPAFVEDPERFDITR-----------------------------RPAPHLAFGFGAHQCI 349 Query: 472 GEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVL 511 G+Q A ++L + T V + + + +V Sbjct: 350 GQQLARIELQIVFGTLFRRFPTLRLAKPVEELRFRNDMVF 389 >3TKT-A nrPDB Length = 450 Score = 120 bits (300), Expect = 2e-27, Method: Composition-based stats. Identities = 68/431 (15%), Positives = 133/431 (30%), Gaps = 75/431 (17%) Query: 93 TVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTT 152 T PK VF ++ ++ A+ V + + + ++ + Sbjct: 91 TFLNNPKS--TVFTLRVGEMMAKAITGGSPHLV---ESLVQMDAPKHPKLRRLTQDWFMP 145 Query: 153 DSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLF--GDEMR 210 + R EI L G + P DE + Sbjct: 146 KNLARL----DGEIRKIANEAIDRMLGAGEEGDFMALVAAPYPLHVVMQILGVPPEDEPK 201 Query: 211 RIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDI 270 +F Q++ D+ +LP + A Y + + R R Sbjct: 202 MLFLTQ--QMFGGQDEDMNKSG--LKDLPPEQISQIVAGAVAEFERYFAGLAAERRR--- 254 Query: 271 DPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQ 330 +P D+ + +I + DG M+D++ A I G T++++SA L L P L Sbjct: 255 NPTDDV--ATVIANAVVDGEPMSDRDTAGYYIITASAGHDTTSASSAGAALALARDPDLF 312 Query: 331 DVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIP 390 + D LP ++E +R P+ R + Sbjct: 313 ARVKA-------------------DRNLLP---GIVEEAIRWTTPVQHFMRTAATDTELC 350 Query: 391 ETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFG 450 + G +++++ A+ F P FDPTR Sbjct: 351 --GQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTR------------------------ 384 Query: 451 KVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVV 510 ++ +L FG G H+C+G A +++ +L + + + + + + Sbjct: 385 -----PANRHLAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEPKRVNSTFVGG 439 Query: 511 LPTEPAEIIWE 521 + P + W+ Sbjct: 440 FKSLP--MRWK 448 >6CVC-A nrPDB Length = 433 Score = 120 bits (300), Expect = 2e-27, Method: Composition-based stats. Identities = 61/367 (16%), Positives = 113/367 (30%), Gaps = 74/367 (20%) Query: 126 FGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGV 185 FG ++ D + R + A T R +RE + V Sbjct: 111 FGSMIVLD--DPRHQRLRSIVSRAFTPKVVARIEASVRERAHRLVAAMIENHPDGQADLV 168 Query: 186 ANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWR 245 + + P I +M I + Q++ + + F P+L + Sbjct: 169 SELAGPLPLQIIC---------DMMGIPEEDHEQIFHWTN---VILGFGDPDLT-TDFDE 215 Query: 246 RDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGIL 305 I RR ++ + DL SL+ DG +++ EIA I ++ Sbjct: 216 FLQVSMAIGGYATALADDRR----VNHHGDLTTSLV--EAEVDGERLSSSEIAMFFILLV 269 Query: 306 MGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNT 365 + G T+ + + +L L P + + + L Sbjct: 270 VAGNETTRNAISHGMLALSRYPDERAKWWSDFDGLAAT---------------------A 308 Query: 366 IKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPT 425 ++E +R P+ + R ++ + + T G V + A+ E F +P FD T Sbjct: 309 VEEIVRWASPVVYMRRTLSQDVDLRGTKMA--AGDKVTLWYCSANRDEEKFADPWTFDVT 366 Query: 426 RWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGG-RHRCIGEQFAYVQLGTIL 484 R +P + FGGG H C+G A ++ + Sbjct: 367 R-----------------------------NPNPQVGFGGGGAHFCLGANLARREIRVVF 397 Query: 485 TTFVYNL 491 + Sbjct: 398 DELRRQM 404 >5DQN-A nrPDB Length = 426 Score = 119 bits (298), Expect = 3e-27, Method: Composition-based stats. Identities = 67/457 (14%), Positives = 141/457 (30%), Gaps = 93/457 (20%) Query: 49 PLVFYWIPWFGSAASYGQQPYEFFESCRQK----YGDVFSFMLLGKIMTVYLGPKGHEFV 104 P + + + + + P E R+ + DV +L K + Sbjct: 4 PNIPSDFDFLDATLNLERLPVEELAELRKSEPIHWVDVPGGTGGFGDKGYWLVTKHADVK 63 Query: 105 FNAKLSDV------SAEDAYKHLTTPV---FGKGVIYDCPNSRLMEQKKFAKFALTTDSF 155 ++ SDV A Y T + V+ + + +K T + Sbjct: 64 EVSRRSDVFGSSPDGAIPVYPQDMTREAVDLQRAVLLNMDAPQHTRLRKIISRGFTPRAI 123 Query: 156 KRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDR 215 R ++R T + + V+ + Q + + + R R Sbjct: 124 GRLEDELRSRAQKIAQTAAAQGAGDFVEQVSCELPLQAIAELLGVPQ-----DDRDKLFR 178 Query: 216 SFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRD 275 ++ + D + ++ + L Y + A ++ + +P D Sbjct: 179 WSNEMTAGEDPEYADVDPAMSSFELISYAMKMAEERAV-----------------NPTED 221 Query: 276 LIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQ 335 ++ L+ DG K++D E ++ + + G T+ ++ ++ + P ++ + Sbjct: 222 IVTKLI--EADIDGEKLSDDEFGFFVVMLAVAGNETTRNSITHGMIAFAQNPDQWELYKK 279 Query: 336 EVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYI 395 E T D E +R P+ + R + + Sbjct: 280 E------------RPETAAD------------EIVRWATPVSAFQRTALEDVEL--GGVQ 313 Query: 396 VPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKG 455 + KG V++S A+ E F++P F+ R Sbjct: 314 IKKGQRVVMSYRSANFDEEVFEDPHTFNILR----------------------------- 344 Query: 456 VSSPYLPFG-GGRHRCIGEQFAYVQLGTILTTFVYNL 491 +P++ FG G H CIG A + + I N+ Sbjct: 345 SPNPHVGFGGTGAHYCIGANLARMTINLIFNAIADNM 381 >3ABA-A nrPDB Length = 403 Score = 118 bits (295), Expect = 6e-27, Method: Composition-based stats. Identities = 69/392 (17%), Positives = 125/392 (31%), Gaps = 84/392 (21%) Query: 113 SAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVT 172 A + T G+G + +K T + P I+ + + Sbjct: 69 HALHTQDGVVTQKPGRGSLLWQDEPEHTSDRKLLAKEFTVRRMQALRPNIQRIVDEHLDA 128 Query: 173 DESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPIN 232 E+ G +++KT LFG + R + + D+ + ++ Sbjct: 129 IEARG------GPVDLVKTFANAVPSMVISDLFGVPVERRAE------FQDIAEAMMRVD 176 Query: 233 FVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKM 292 +AA ++ + ++ RR +P DLI +L+ + DGV + Sbjct: 177 Q--------DAAATEAAGMRLGGLLYQLVQERR----ANPGDDLISALIT-TEDPDGV-V 222 Query: 293 TDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLT 352 D + N +L+ T+A L + P ++ ++ Sbjct: 223 DDMFLMNAAGTLLIAAHDTTACMIGLGTALLLDSPDQLALLREDPS-------------- 268 Query: 353 YEDLQKLPSVNNTIKETLRMHMPLH-SIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHT 411 V N ++E LR R T + + + KG V+ A Sbjct: 269 --------LVGNAVEELLRYLTIGQFGGERVATRDVEL--GGVRIAKGEQVVAHVLAADF 318 Query: 412 SERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCI 471 + + PE FD TR +P+L FG G H+CI Sbjct: 319 DPAFVEEPERFDITR-----------------------------RPAPHLAFGFGAHQCI 349 Query: 472 GEQFAYVQLGTILTTFVYNLRWTIDGYKVPDP 503 G+Q A ++L + T L G ++ P Sbjct: 350 GQQLARIELQIVFETLFRRL----PGLRLAKP 377 >6FSH-A nrPDB Length = 398 Score = 118 bits (294), Expect = 8e-27, Method: Composition-based stats. Identities = 52/387 (13%), Positives = 104/387 (26%), Gaps = 86/387 (22%) Query: 129 GVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANV 188 G + D + T +R P+I E + + E + + Sbjct: 86 GNLMDYDPPEHTRLRHLLTPGFTQRRMRRLAPRIEEIVTDRLDAMEQAGP---PADLIEL 142 Query: 189 MKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDA 248 + + + D+ L + L Sbjct: 143 FADEVPGAVLCELIGVPRDDRDMFMKLCHGHLDASLS---------------------QK 181 Query: 249 AQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGG 308 + + + + + + R DP I S++ + G +TD+E+ + + +++ G Sbjct: 182 RRAALGDKFSRYLLAMIARERKDPGDGFIGSIVA----EHGDTITDEELRGVCVQLMLAG 237 Query: 309 QHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKE 368 + +L L P + GD + + E Sbjct: 238 DDNVSGMIGLGVLALLRHPEQIAALR-----------GDDQS-----------ADRAVDE 275 Query: 369 TLRM-HMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRW 427 +R +P R + + + ++ +G VL S A+ + + D TR Sbjct: 276 LIRYLTVPYAPTPRTAVEDVMVADQ--VIKEGETVLCSLPMANRDRALLPDADRLDVTR- 332 Query: 428 DTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTF 487 P++ FG G H C+G +QL T Sbjct: 333 ----------------------------TPVPHVAFGHGIHHCLGAALTRLQLRIAYTAL 364 Query: 488 VYNLRWTIDGYKVPDPDYSSMVVLPTE 514 ++ DP M T Sbjct: 365 WRRF----PALQLADPAQEIMFRTSTP 387 >2FR7-A nrPDB Length = 412 Score = 116 bits (290), Expect = 2e-26, Method: Composition-based stats. Identities = 75/455 (16%), Positives = 139/455 (30%), Gaps = 96/455 (21%) Query: 47 RAPLVFYWIPWFG---SAASYGQQPYEFFESCRQKYGDVFSF---MLLG-----KIMTVY 95 +P G A Y PY E+ R+ G V + G ++ V Sbjct: 12 TPSQHGAGVPHLGIDPFALDYFADPYPEQETLREA-GPVVYLDKWNVYGVARYAEVYAVL 70 Query: 96 LGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSF 155 P LSD E ++ + +I + + L+ + Sbjct: 71 NDPLTFCSSRGVGLSDFKKEKPWRPPS-------LILEADPPAHTRTRAVLSKVLSPATM 123 Query: 156 KRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDR 215 KR DE +A++ + P S+F D M + Sbjct: 124 KRLRDGFAAAADA--KIDELLARGGNIDAIADLAEAYP--------LSVFPDAMGLKQEG 173 Query: 216 SFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRD 275 + P + N P R +A ++ SA + + + +R ++ P Sbjct: 174 R---------ENLLPYAGLVFNAFGPPNELRQSAIER-SAPHQAYVAEQCQRPNLAPG-- 221 Query: 276 LIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQ 335 + D ++T +E L+ +L G T+ + A + L P + Sbjct: 222 --GFGACIHAFSDTGEITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRA 279 Query: 336 EVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYI 395 + N +E +R P+ + FR T + + Sbjct: 280 DPS----------------------LARNAFEEAVRFESPVQTFFRTTTRDVELAGA--T 315 Query: 396 VPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKG 455 + +G VL+ G A+ R +D+P+ +D TR Sbjct: 316 IGEGEKVLMFLGSANRDPRRWDDPDRYDITR----------------------------- 346 Query: 456 VSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYN 490 +S ++ FG G H C+G+ A ++ +L Sbjct: 347 KTSGHVGFGSGVHMCVGQLVARLEGEVVLAALARK 381 >4TX3-A nrPDB Length = 404 Score = 116 bits (289), Expect = 3e-26, Method: Composition-based stats. Identities = 52/387 (13%), Positives = 103/387 (26%), Gaps = 86/387 (22%) Query: 129 GVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANV 188 G + D + T +R P+I E + + E + + Sbjct: 92 GNLMDYDPPEHTRLRHLLTPGFTQRRMRRLAPRIEEIVTDRLDAMEQAGP---PADLIEL 148 Query: 189 MKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDA 248 + + + D+ L + L Sbjct: 149 FADEVPGAVLCELIGVPRDDQAMFLQLCHRHLDASLSA---------------------R 187 Query: 249 AQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGG 308 + + + + + R DP I S++ + G +TD+E+ + + +++ G Sbjct: 188 KRAAAGEAFARYLVAMMARERKDPGDGFIGSIVA----EHGDTITDEELRGVCVQLMLAG 243 Query: 309 QHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKE 368 + +L L P + GD + + E Sbjct: 244 DDNVSGMIGLGVLALLRHPEQIAALR-----------GDDQS-----------ADRAVDE 281 Query: 369 TLRM-HMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRW 427 +R +P R + + + ++ +G VL S A+ + + D TR Sbjct: 282 LIRYLTVPYAPTPRTAVEDVMVADQ--VIKEGETVLCSLPMANRDRALLPDADRLDVTR- 338 Query: 428 DTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTF 487 P++ FG G H C+G +QL T Sbjct: 339 ----------------------------TPVPHVAFGHGIHHCLGAALTRLQLRIAYTAL 370 Query: 488 VYNLRWTIDGYKVPDPDYSSMVVLPTE 514 ++ DP M T Sbjct: 371 WRRF----PALQLADPAQEIMFRTSTP 393 >5Y1I-A nrPDB Length = 403 Score = 115 bits (288), Expect = 4e-26, Method: Composition-based stats. Identities = 55/409 (13%), Positives = 117/409 (28%), Gaps = 83/409 (20%) Query: 88 LGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPV----FGKGVIYDCPNSRLMEQK 143 V + + ++S D Y H++ + + + Sbjct: 41 GSTPWVVTRHADQRALLSDPRVSHDGLRDGYPHISADFKFLSMAQPSFAGQDDPEHGRIR 100 Query: 144 KFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRS 203 + T + P I++ + K + + + + Sbjct: 101 RMVTLPFTARRIEAMRPAIQKITDELI---DGMLAGPKPVDLVEALALPVPVRVICEMLG 157 Query: 204 LFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKS 263 + ++ + + A +Y D +G DA + I+ +K Sbjct: 158 VPYEDREFLQQNNNAMIYRDTAQG-------------------DAQKAAIAQAMY--LKE 196 Query: 264 RRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHL 323 D D++ L + + ++T + A + + +L G T+A+ A L L Sbjct: 197 LVGTKLGDRGDDILSDL---AVQVEAGEITQDDAAGIGMMLLGAGHETTANMIALGTLAL 253 Query: 324 GEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLH-SIFRK 382 E P + D + NT++E LR ++ R Sbjct: 254 LENPEQLAEVR--------------------DSDDPKVIVNTVEELLRYLTIAQDTVRRI 293 Query: 383 VTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDN-PEDFDPTRWDTAAAKANSVSFNS 441 + I ++ G ++ A+ + P+ D R Sbjct: 294 AAEDIEI--GGVVIKAGEGIVFPLNAANWDPDLYPEAPDRLDIHR--------------- 336 Query: 442 SDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYN 490 + +L FG G H+C+G A V+L + +T + Sbjct: 337 -------------ANARRHLAFGYGVHQCLGATLARVELQIVYSTLLRR 372 >2Z36-A nrPDB Length = 413 Score = 114 bits (286), Expect = 6e-26, Method: Composition-based stats. Identities = 47/260 (18%), Positives = 82/260 (31%), Gaps = 63/260 (24%) Query: 246 RDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGIL 305 R A ++ A I R + +P DL + + + + +L +L Sbjct: 190 RRRAFAELRAYIDDLI----TRKESEPGDDLFSRQIARQRQEG--TLDHAGLVSLAFLLL 243 Query: 306 MGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNT 365 G T+A+ + ++ L P E + ++K G Sbjct: 244 TAGHETTANMISLGVVGLLSHP--------EQLTVVKANPGR--------------TPMA 281 Query: 366 IKETLRMHMPLHSIF-RKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDP 424 ++E LR + R T + I + G V+VS A+ F +P D Sbjct: 282 VEELLRYFTIADGVTSRLATEDVEI--GGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDV 339 Query: 425 TRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTIL 484 R + +L FG G H+C+G+ A ++L + Sbjct: 340 ER-----------------------------GARHHLAFGFGPHQCLGQNLARMELQIVF 370 Query: 485 TTFVYN---LRWTIDGYKVP 501 T LR + VP Sbjct: 371 DTLFRRIPSLRLAVPMEDVP 390 >1F4U-A nrPDB Length = 368 Score = 114 bits (286), Expect = 7e-26, Method: Composition-based stats. Identities = 42/215 (19%), Positives = 73/215 (33%), Gaps = 57/215 (26%) Query: 289 GVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDL 348 ++D E +I +L+ G T+ + + ++ +L I +E + Sbjct: 191 NSNLSDIEKLGYIILLLIAGNETTTNLISNSVIDFTRF-NLWQRIREENL---------- 239 Query: 349 NDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGY 408 + I+E LR P+ RK +++ + + +G YV V Sbjct: 240 ------------YLKA-IEEALRYSPPVMRTVRKTKERVKL--GDQTIEEGEYVRVWIAS 284 Query: 409 AHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRH 468 A+ E F + E F P R +P+L FG G H Sbjct: 285 ANRDEEVFHDGEKFIPDR-----------------------------NPNPHLSFGSGIH 315 Query: 469 RCIGEQFAYVQLGTILTTFVYNLRW--TIDGYKVP 501 C+G A ++ + F R +D KVP Sbjct: 316 LCLGAPLARLEARIAIEEFSKRFRHIEILDTEKVP 350 >2RFC-A nrPDB Length = 343 Score = 114 bits (285), Expect = 8e-26, Method: Composition-based stats. Identities = 42/224 (18%), Positives = 76/224 (33%), Gaps = 56/224 (25%) Query: 288 DGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGD 347 K+T E ++ +++GG T+ + + + E P + + + LK + G Sbjct: 169 KNRKLTMDEKIKYIMLLIIGGNETTTNLIGNMIRVIDENPDI-------IDDALKNRSG- 220 Query: 348 LNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPG 407 ++ETLR + P+ + + N + KG V+V G Sbjct: 221 -----------------FVEETLRYYSPIQFLPHRFAAEDSYI-NNKKIKKGDQVIVYLG 262 Query: 408 YAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGR 467 A+ E +FD P+ F R +L FG G Sbjct: 263 SANRDETFFDEPDLFKIGR------------------------------REMHLAFGIGI 292 Query: 468 HRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVL 511 H C+G A ++ L + + + YK + MV+ Sbjct: 293 HMCLGAPLARLEASIALNDILNHFKRIKIDYKKSRLLDNKMVLG 336 >6GII-A nrPDB Length = 479 Score = 114 bits (285), Expect = 9e-26, Method: Composition-based stats. Identities = 62/445 (13%), Positives = 135/445 (30%), Gaps = 95/445 (21%) Query: 63 SYGQQPYEFFESCRQK----YGDVFSFMLLGKIMTV---------YLGPKGHEFVFNAKL 109 +Y P +F R++ Y ++ ++ + T+ + + Sbjct: 75 AYMADPAQFVRWAREQVPIFYAPKLNYWVVTRYDTIKQIFRDPVTFSPSNVLQSFAQPSA 134 Query: 110 SDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNY 169 + Y + F + ++ + +E+++ ++ + P +RE + Sbjct: 135 EVRQVLERYGY----AFNRTLV-NEDEPMHLERRRVLMEPFASEHLAEHEPMVRELVRRA 189 Query: 170 FVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFG---DEMRRIFDRSFAQLYSDLDK 226 + G A+++ FT + G D+ ++ + A + + Sbjct: 190 VN-------RFIDTGRADLVDQMIWEVPFTVALHFLGVDDDDREKMRRFAIAHTVNAFGR 242 Query: 227 GFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTY 286 P P A + E+ + R P I Sbjct: 243 ------------PSPEEQLAVAETVGQFWQFCGEVLEKMRRTADGPG---WMRYSIRQQK 287 Query: 287 KDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGG 346 +TD + +++ I++ T+ + L L E + I Sbjct: 288 LYPDVVTDSYLHSMMQAIIVAAHETTVFATTNALKTLLEHETVWREICA----------- 336 Query: 347 DLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSP 406 D +P +E LR + P+ R+ T + + +P G +L+ Sbjct: 337 --------DPSLIP---AAAEECLRYNGPVAGWRRRTTREVEVE--GVRLPVGANILMVV 383 Query: 407 GYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGG 466 A+ +FD+PE FD R +S +L FG G Sbjct: 384 ASANHDSAHFDDPEFFDIGR----------------------------SNASEHLNFGYG 415 Query: 467 RHRCIGEQFAYVQLGTILTTFVYNL 491 H+C+G +++ ++ L Sbjct: 416 AHQCLGRNLGRMEMQIMIEELSRRL 440 >4PWV-A nrPDB Length = 446 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 61/438 (13%), Positives = 130/438 (29%), Gaps = 84/438 (19%) Query: 80 GDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRL 139 GD F ++ + V K ++ + + K + + A ++ + Sbjct: 71 GDAPGFWVVSRYADVMALYKDNKKLTSEKGNVLVTLLAGGDSA----AGKMLAVTDGAMH 126 Query: 140 MEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFT 199 + + + + K V +IR V + A+V + P TI Sbjct: 127 RGLRNVLLKSFSPQALKPIVDQIRVNTTRLVVDAARRGECDFA---ADVAEQIPLNTISD 183 Query: 200 ASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMK 259 + + + + + L S+ ++ A+ +I + + Sbjct: 184 L-LGVPAADREFLLKLNKSALSSEDADQSATDAWL--------------ARNEILLYFSE 228 Query: 260 EIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWF 319 + RR P D+I L DG +T++ I +++GG TS + Sbjct: 229 LVAERR----AKPTEDVISVLANSMV--DGKPLTEEVIVLNCYSLILGGDETSRLSMIDS 282 Query: 320 LLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSI 379 + + P +++ V + + +E LR P Sbjct: 283 VQTFTQYPDQWELLRDGKVT----------------------LESATEEVLRWATPAMHF 320 Query: 380 FRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSF 439 R+ + + ++ G V + A+ E F +P FD R Sbjct: 321 GRRAVTDMELH--GQVIAAGDVVTLWNNSANRDEEVFADPYAFDLNR------------- 365 Query: 440 NSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTF---VYNLRWTID 496 + ++ FG G H C+G ++ +L T + Sbjct: 366 ----------------SPNKHITFGYGPHFCLGAYLGRAEVHALLDALRTYTTGFEITGE 409 Query: 497 GYKVPDPDYSSMVVLPTE 514 ++ + + LP Sbjct: 410 PQRIHSNFLTGLSRLPVR 427 >1LG9-A nrPDB Length = 398 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 53/376 (14%), Positives = 103/376 (27%), Gaps = 86/376 (22%) Query: 129 GVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANV 188 G + D ++ T +R P I + + + DE + +A V Sbjct: 86 GNLMDYDPPEHTRLRRKLTPGFTLRKMQRMAPYIEQIVNDRL--DEMERAGSPADLIAFV 143 Query: 189 MKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDA 248 P A R D + LD + Sbjct: 144 ADKVPG-----AVLCELVGVPRDDRDMFMKLCHGHLDASLS-----------------QK 181 Query: 249 AQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGG 308 + + + + + + R +P +I +++ + G TD+E+ + +++ G Sbjct: 182 RRAALGDKFSRYLLAMIARERKEPGEGMIGAVVA----EYGDDATDEELRGFCVQVMLAG 237 Query: 309 QHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKE 368 + +L + P D + + E Sbjct: 238 DDNISGMIGLGVLAMLRHPEQIDAFRGDEQS----------------------AQRAVDE 275 Query: 369 TLRM-HMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRW 427 +R +P R L + + KG V+ S A+ + + D TR Sbjct: 276 LIRYLTVPYSPTPRIAREDLTLAGQE--IKKGDSVICSLPAANRDPALAPDVDRLDVTR- 332 Query: 428 DTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTF 487 P++ FG G H C+G A ++L T+ T Sbjct: 333 ----------------------------EPIPHVAFGHGVHHCLGAALARLELRTVFTEL 364 Query: 488 VYNLRWTIDGYKVPDP 503 ++ DP Sbjct: 365 WRRF----PALRLADP 376 >6G5O-A nrPDB Length = 399 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 46/257 (17%), Positives = 86/257 (33%), Gaps = 58/257 (22%) Query: 254 SATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSA 313 + I + +R +P D+ LL + +G K+T +E+ +++ GG+ T Sbjct: 169 ANILYHYIDEQIDRASENPGDDMYSVLLN--SEFEGRKLTKEEVKGVMVLTFAGGRDTVI 226 Query: 314 STSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMH 373 + + +L E P + + +E ++E +R Sbjct: 227 NAVTNSIAYLAEHPEALERLRKEPE----------------------ITGRAVEEMIRYF 264 Query: 374 MPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAK 433 PL + R VT + E + V + + A+ F+NP + R Sbjct: 265 SPLTQMGRVVTEDTHVCE--HAVKADSRISLCWASANRDAAVFENPNEIVLDR------- 315 Query: 434 ANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL-R 492 +P++ FG H C+G A L +L T + Sbjct: 316 ----------------------KVNPHVGFGFSHHNCLGATHARQILKILLQTLAQKVAS 353 Query: 493 WTIDGYK--VPDPDYSS 507 + I YK + D D+ Sbjct: 354 FEILDYKENIEDLDHFQ 370 >1EHE-A nrPDB Length = 403 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 62/406 (15%), Positives = 111/406 (27%), Gaps = 83/406 (20%) Query: 89 GKIMTVYLGPKGHEFVFNAK-LSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAK 147 K + + V + ++SA P F D M Q+ + Sbjct: 48 HKDVCFVATSEKLSKVRTRQGFPELSASGKQAAKAKPTF-----VDMDPPEHMHQRSMVE 102 Query: 148 FALTTDSFKRYVPKIREEILNYFVTDESFKLKEKT-HGVANVMKTQPEITIFTASRSLFG 206 T ++ K P I+ + + + V P I+T Sbjct: 103 PTFTPEAVKNLQPYIQRTVDDLLEQMKQKGCANGPVDLVKEFALPVPSYIIYT------- 155 Query: 207 DEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRE 266 + F L + N AA +++ ++ R Sbjct: 156 -----LLGVPFNDLEYLTQQNAIRTNGS------STAREASAANQELLDYLAILVEQR-- 202 Query: 267 RGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEK 326 ++P D+I L + +D + +L+ G T + A + L + Sbjct: 203 --LVEPKDDIISKLCTEQVKPGNIDKSD--AVQIAFLLLVAGNATMVNMIALGVATLAQH 258 Query: 327 PHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMP-LHSIFRKVTN 385 P + ++E R H +I R Sbjct: 259 PDQLAQLKANPS----------------------LAPQFVEELCRYHTASALAIKRTAKE 296 Query: 386 PLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEV 445 + I + +V ++ S A+ E F+NP++F+ R Sbjct: 297 DVMI--GDKLVRANEGIIASNQSANRDEEVFENPDEFNMNRKWPPQDP------------ 342 Query: 446 DYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL 491 L FG G HRCI E A +L T+ +T Sbjct: 343 ---------------LGFGFGDHRCIAEHLAKAELTTVFSTLYQKF 373 >1UED-A nrPDB Length = 406 Score = 113 bits (283), Expect = 2e-25, Method: Composition-based stats. Identities = 84/487 (17%), Positives = 139/487 (28%), Gaps = 105/487 (21%) Query: 58 FGSAAS----YGQQPYEF-FESCRQKYGDVFSFMLLGKIMTVYLGP---KGHEFVFNAKL 109 G ++P F + + D F G ++ + G +FV+ A Sbjct: 1 MGHDIDQVAPLLREPANFQLRTNCDPHEDNFGLRAHGPLVRIVGESSTQLGRDFVWQAHG 60 Query: 110 SDVSAEDAYKH---LTTPVFGK------------GVIYDCPNSRLMEQKKFAKFALTTDS 154 +V H T P F + G I +K T Sbjct: 61 YEVVRRILGDHEHFTTRPQFTQSKSGAHVEAQFVGQISTYDPPEHTRLRKMLTPEFTVRR 120 Query: 155 FKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFD 214 +R P I+ I + E+ G LF D + Sbjct: 121 IRRMEPAIQSLIDDRLDLLEAEGPSADLQG-------------------LFADPVGAHAL 161 Query: 215 RSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNR 274 + D + F + N L + AA Y+ + +R+ DP+ Sbjct: 162 CELLGIPRDDQREFVR--RIRRNADLSRGLKARAADSAAFNRYLDNLLARQR---ADPD- 215 Query: 275 DLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIY 334 D LL G +TD+E+ L +++GG T A + +L L + P Sbjct: 216 ---DGLLGMIVRDHGDNVTDEELKGLCTALILGGVETVAGMIGFGVLALLDNP------- 265 Query: 335 QEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHS-IFRKVTNPLRIPETN 393 +L +E +K + E +R P+ + R + I Sbjct: 266 ------------GQIELLFESPEK---AERVVNELVRYLSPVQAPNPRLAIKDVVID--G 308 Query: 394 YIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVS 453 ++ G YVL S A+ E +P+ D R + Sbjct: 309 QLIKAGDYVLCSILMANRDEALTPDPDVLDANRAAVSD---------------------- 346 Query: 454 KGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPT 513 + FG G H C+G A L T + + Y S V Sbjct: 347 -------VGFGHGIHYCVGAALARSMLRMAYQTLWRRFPGLRLAVPIEEVKYRSAFVDCP 399 Query: 514 EPAEIIW 520 + + W Sbjct: 400 DQVPVTW 406 >4MM0-A nrPDB Length = 399 Score = 113 bits (283), Expect = 2e-25, Method: Composition-based stats. Identities = 56/362 (15%), Positives = 110/362 (30%), Gaps = 79/362 (21%) Query: 131 IYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMK 190 + ++ T +R P++ E EK A++++ Sbjct: 85 VMTTDPPVHTRLRRLLSRDFTARRIERMRPRLEEIAEGLL------DEMEKKGAPADIVE 138 Query: 191 TQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQ 250 + T L G M + F +L AA+ Sbjct: 139 SLAVPFPITVICELLGVPMVDV-------------ARFRGWADTMVSLTGYSMEDWTAAR 185 Query: 251 KKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQH 310 + + + ++RE +P DL+ +L+ + + ++TD ++ +L + +L+ G Sbjct: 186 DALESYLDGLVAAKRE----NPGSDLLSALVATAAEDN--ELTDHDVRSLSLILLLAGYE 239 Query: 311 TSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETL 370 +++ +L L P + D LP + ++E + Sbjct: 240 PASNQLGSSVLTLLRFPDRLAELR-------------------RDPGLLP---SAVEELM 277 Query: 371 RMHMPLHS-IFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDT 429 R +FR + I +T +P VL S A+ R FD+P R Sbjct: 278 RYAPAGDGALFRVTLEDVTIGDT--HIPANSAVLASTQAANWDPRRFDDPTGLRLDR--- 332 Query: 430 AAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVY 489 + + G G H C+G A V+L + + Sbjct: 333 --------------------------PDNQHTALGHGIHFCLGAALARVELQVAIGALLR 366 Query: 490 NL 491 Sbjct: 367 RF 368 >5YSW-A nrPDB Length = 441 Score = 113 bits (283), Expect = 2e-25, Method: Composition-based stats. Identities = 71/414 (17%), Positives = 125/414 (30%), Gaps = 87/414 (21%) Query: 94 VYLGPK--GHEFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALT 151 V P+ F ++ ++S E + L G + +K T Sbjct: 89 VLSDPRFSSDRFQYHPWFKELSPE-FRERLRDDKARAGSFINMDPPEHTRYRKLLTGQFT 147 Query: 152 TDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRR 211 + +I E + D + P + I L G Sbjct: 148 VRRIRELGARIDEIVAGRV--DAMLAGGTTADLMTEFAFPAPSLMI----CELLGVRYED 201 Query: 212 IFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDID 271 F Q S L + P+ DA + + A + + Sbjct: 202 R--AEFQQRASALLQMNAPVA--------EAVKNADALRAFMQALVTDK--------RAN 243 Query: 272 PNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQD 331 P D+I L+ H+ +TD E+ N+ +L+ G T+AS + L ++P Sbjct: 244 PAGDIISGLIHHAGAD--PALTDDELINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLA 301 Query: 332 VIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPL-HSIFRKVTNPLRIP 390 + + + ++E LR + IFR L Sbjct: 302 TLRDDPSRIAD----------------------AVEELLRYLSVVNPGIFRFAKEDLEF- 338 Query: 391 ETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFG 450 +P G V+VS + R++ +P+ D TR Sbjct: 339 -AGEHIPAGSTVVVSVVATNRDARHWPDPD-LDLTR------------------------ 372 Query: 451 KVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL---RWTIDGYKVP 501 P+L FG G H+C+G+Q A +++ + L R + +VP Sbjct: 373 -----PRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRLAVPPEEVP 421 >4OQS-A nrPDB Length = 433 Score = 113 bits (283), Expect = 2e-25, Method: Composition-based stats. Identities = 54/367 (14%), Positives = 104/367 (28%), Gaps = 89/367 (24%) Query: 127 GKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVA 186 G + ++ T K P+I + ++ D K V Sbjct: 90 APGWFINMDAPEHTRYRRMLISQFTVRRIKELEPRIVQITEDHL--DAMAKAGPPVDLVQ 147 Query: 187 NVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRR 246 P + I + D + T Sbjct: 148 AFALPVPSLVICELLGVSYADHAFFQEQTTIMASVDKTQDEVTT---------------- 191 Query: 247 DAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILM 306 A K++ + + ++R + P DL+ SL+ + +TD+E+ N+ + +L+ Sbjct: 192 --ALGKLTRYIAELVATKR----LSPKDDLLGSLITDTD------LTDEELTNIALLLLV 239 Query: 307 GGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTI 366 G T+A+ L + P + + + Sbjct: 240 AGHETTANMLGLGTFALLQHPEQIAALDS---------------------------PDAV 272 Query: 367 KETLRMHMPLHSIF--RKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDP 424 +E LR +H R + + ++ KG V + + + FD P+ Sbjct: 273 EELLRYLSIVHLGTPNRAALEDVELE--GQMIRKGDTVAIGLPAVNRDPKVFDEPDILQL 330 Query: 425 TRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTIL 484 R D + + FGGG H+C+G+Q A V++ Sbjct: 331 DRVD----------------------------ARKHAAFGGGIHQCLGQQLARVEMRIGF 362 Query: 485 TTFVYNL 491 T Sbjct: 363 TRLFARF 369 >3IVY-A nrPDB Length = 433 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 54/365 (14%), Positives = 111/365 (30%), Gaps = 84/365 (23%) Query: 130 VIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVM 189 V+ + +K T + R +++E + G + + Sbjct: 115 VMLNMDAPHHTRLRKIISRGFTPRAVGRLHDELQERAQK-------IAAEAAAAGSGDFV 167 Query: 190 KTQPEITIFTASRSLFG--DEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRD 247 + A L G E R ++ + D + I+ Sbjct: 168 EQVSCELPLQAIAGLLGVPQEDRGKLFHWSNEMTGNEDPEYAHIDP-------------K 214 Query: 248 AAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMG 307 A+ ++ MK + + +P D++ L+ DG K++D E ++ + + Sbjct: 215 ASSAELIGYAMKMAEEK----AKNPADDIVTQLI--QADIDGEKLSDDEFGFFVVMLAVA 268 Query: 308 GQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIK 367 G T+ ++ ++ E P Q +Y++V Sbjct: 269 GNETTRNSITQGMMAFAEHPD-QWELYKKVRP-----------------------ETAAD 304 Query: 368 ETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRW 427 E +R P+ + R + + + KG V++ A+ E F +P F+ R Sbjct: 305 EIVRWATPVTAFQRTALRDYEL--SGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILR- 361 Query: 428 DTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFG-GGRHRCIGEQFAYVQLGTILTT 486 +P++ FG G H CIG A + + I Sbjct: 362 ----------------------------NPNPHVGFGGTGAHYCIGANLARMTINLIFNA 393 Query: 487 FVYNL 491 ++ Sbjct: 394 VADHM 398 >4OQR-A nrPDB Length = 457 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 57/367 (15%), Positives = 105/367 (28%), Gaps = 89/367 (24%) Query: 127 GKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVA 186 G + ++ T K P+I ++ D K V Sbjct: 129 APGWFTNMDAPEHTRYRRMLISQFTVRRIKELEPRIVRITEDHL--DAMAKAGPPVDLVQ 186 Query: 187 NVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRR 246 P + I + D + T Sbjct: 187 AFALPVPSLVICELLGVSYADHAFFQEQTTIMVSVDKTQDEVTT---------------- 230 Query: 247 DAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILM 306 A K++ + + ++R + P DL+ SL+ + +TD+E+ N+ + +L+ Sbjct: 231 --ALGKLTRYIAELVATKR----LSPKDDLLGSLITDTD------LTDEELTNIALILLV 278 Query: 307 GGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTI 366 G T+A+ L + P E + L S + Sbjct: 279 AGHETTANMLGLGTFALLQHP--------------------------EQIANLDSPDAV- 311 Query: 367 KETLRMHMPLHSIF--RKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDP 424 +E LR +H R + + ++ KG V + + + FD P+ Sbjct: 312 EELLRYLSIVHLGTPNRAALEDVELE--GQMIRKGDTVAIGLPAVNRDPKVFDEPDILQL 369 Query: 425 TRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTIL 484 R D + + FGGG H+C+G+Q A V++ Sbjct: 370 DRVD----------------------------ARKHAAFGGGIHQCLGQQLARVEMRIGF 401 Query: 485 TTFVYNL 491 T Sbjct: 402 TRLFARF 408 >1Q5D-A nrPDB Length = 419 Score = 111 bits (278), Expect = 6e-25, Method: Composition-based stats. Identities = 65/436 (14%), Positives = 124/436 (28%), Gaps = 81/436 (18%) Query: 64 YGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAED----AYK 119 Y + P+ E R+ +F + V VF + VS E+ A Sbjct: 24 YAEDPFPAIERLREA-TPIFYWDEG--RSWVLTRYHDVSAVFRDERFAVSREEWESSAEY 80 Query: 120 HLTTPVFG---KGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESF 176 P K ++ P +K + T+ + +I+ + Sbjct: 81 SSAIPELSDMKKYGLFGLPPEDHARVRKLVNPSFTSRAIDLLRAEIQRTVDQLLDARSGQ 140 Query: 177 KLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFP 236 + +V++ E A +L + + V Sbjct: 141 E-------EFDVVRDYAEGIPMRAISALL------KVPAECDEKFRRFGSATARALGVGL 187 Query: 237 NLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQE 296 + + A + + R R +P + + ++L+ + DG +++ +E Sbjct: 188 VPRVDEETKTLVASVTEGLALLHGVLDERRR---NPLENDVLTMLLQAE-ADGSRLSTKE 243 Query: 297 IANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDL 356 + L+ I+ G T+ A+ +L+L P +++ E Sbjct: 244 LVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAEPG------------------ 285 Query: 357 QKLPSVNNTIKETLRMHMPL-HSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERY 415 + N + E LR L R L + + KG V + A Sbjct: 286 ----LMRNALDEVLRFDNILRIGTVRFARQDLEYCGAS--IKKGEMVFLLIPSALRDGTV 339 Query: 416 FDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQF 475 F P+ FD R +S L +G G H C G Sbjct: 340 FSRPDVFDVRR-----------------------------DTSASLAYGRGPHVCPGVSL 370 Query: 476 AYVQLGTILTTFVYNL 491 A ++ + T Sbjct: 371 ARLEAEIAVGTIFRRF 386 >2ZBZ-A nrPDB Length = 412 Score = 111 bits (278), Expect = 7e-25, Method: Composition-based stats. Identities = 66/440 (15%), Positives = 133/440 (30%), Gaps = 104/440 (23%) Query: 68 PYEF---FESCRQKYGDVFSFMLL-GKIMTVYLGPKGHEFVF-NAKLSDVSAEDAYKHLT 122 PY+ + R G + L G+ V + + + +LS +D + T Sbjct: 23 PYQLPDGYAQLRDTPGPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPA-T 81 Query: 123 TPVF-----GKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFK 177 +P F +++ T K P++ E + + DE Sbjct: 82 SPAFEAVRESPQAFIGLDPPEHGTRRRMTISEFTVKRIKGMRPEVEEVVHGFL--DEMLA 139 Query: 178 LKEKTHGVANVMKTQPEITIF------TASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPI 231 V+ P + I A F D +R+ + AQ Sbjct: 140 AGPTADLVSQFALPVPSMVICRLLGVPYADHEFFQDASKRLVQSTDAQ------------ 187 Query: 232 NFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVK 291 A+ ++ I + +P L+ +L+ + Sbjct: 188 -------------SALTARNDLAGYLDGLI----TQFQTEPGAGLVGALVADQLA--NGE 228 Query: 292 MTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDL 351 + +E+ + + +L+ G T+AS ++ ++ L + P + Sbjct: 229 IDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRA---------------- 272 Query: 352 TYEDLQKLPSVNNTIKETLRMHMPLHSIF-RKVTNPLRIPETNYIVPKGHYVLVSPGYAH 410 D +P ++E LR R T + + ++ G V+V A+ Sbjct: 273 ---DRSLVP---GAVEELLRYLAIADIAGGRVATADIEVE--GQLIRAGEGVIVVNSIAN 324 Query: 411 TSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRC 470 +++P+ D R + +L FG G H+C Sbjct: 325 RDGTVYEDPDALDIHR-----------------------------SARHHLAFGFGVHQC 355 Query: 471 IGEQFAYVQLGTILTTFVYN 490 +G+ A ++L IL + Sbjct: 356 LGQNLARLELEVILNALMDR 375 >5H1Z-A nrPDB Length = 407 Score = 111 bits (277), Expect = 7e-25, Method: Composition-based stats. Identities = 73/423 (17%), Positives = 126/423 (29%), Gaps = 81/423 (19%) Query: 78 KYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNS 137 +G +S I+TV P + L+D + P+F Sbjct: 44 DFGPYWSVSSYKPIITVESLPDLYSSAGGITLADFIENNPTDVRM-PMF-----IAMDRP 97 Query: 138 RLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITI 197 + Q++ A T R IR + E + V+ + TQ + Sbjct: 98 KHTGQRRTVAPAFTPSEMVRMSDNIRMRTAEVLDSLEWNTPFDWVDTVSVELTTQMLAIL 157 Query: 198 FTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATY 257 F +R +SD + L L + Sbjct: 158 FDFP----------WEERRKLTFWSDWAGDIELVKN--EELRLERLRHMYEC----GGYF 201 Query: 258 MKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSA 317 ++ P DLI S++IHS +M E LI +++GG T+ +T + Sbjct: 202 QNLWNAK---IGKPPTPDLI-SMMIHSDAM--AEMDQMEFLGNLILLIVGGNDTTRNTMS 255 Query: 318 WFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLH 377 L P + + D +P NT++E +R PL Sbjct: 256 AVAYGLDLFPDQRAKLEA-------------------DPSMIP---NTVQEIIRWQTPLA 293 Query: 378 SIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSV 437 + R T + + G + + A+ E F+N + R Sbjct: 294 HMRRTATVDSELE--GQQIKAGDKLALWYISANRDESVFENADRIIVDR----------- 340 Query: 438 SFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFV-YNLRWTID 496 + +L FG G HRC+G + A +Q+ +L +R + Sbjct: 341 -----------------PNARRHLAFGHGIHRCVGARLAELQIAVLLEEMAKRRMRVNVL 383 Query: 497 GYK 499 G Sbjct: 384 GEP 386 >5HDI-A nrPDB Length = 404 Score = 111 bits (277), Expect = 7e-25, Method: Composition-based stats. Identities = 60/397 (15%), Positives = 115/397 (28%), Gaps = 75/397 (18%) Query: 95 YLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGK-GVIYDCPNSRLMEQKKFAKFALTTD 153 P+ A ++ + A P+ G V+ + +K L Sbjct: 53 IGRPEDFSSNLTATMTYTAEGTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAK 112 Query: 154 SFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIF 213 + + +V E +AN P + + E+ + Sbjct: 113 RIRVMEQFTVQAADRLWVDGMQDGCIEWMGAMAN---RLPMMVV---------AELIGLP 160 Query: 214 DRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPN 273 D AQL + + N L A ++S ++ R DP Sbjct: 161 DPDIAQLVKWGYAATQLLEGLVENDQLVA---AGVALMELSGYIFEQFD----RAAADPR 213 Query: 274 RDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVI 333 +L+ L + +T Q +++ + G ++A+ + L +P +Q + Sbjct: 214 DNLLGELATACASGELDTLTAQ---VMMVTLFAAGGESTAALLGSAVWILATRPDIQQQV 270 Query: 334 YQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETN 393 + I+ETLR P +R V N + T Sbjct: 271 RANPE----------------------LLGAFIEETLRYEPPFRGHYRHVRNATTLDGTE 308 Query: 394 YIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVS 453 +P ++L+ G A+ F+ P +F R Sbjct: 309 --LPADSHLLLLWGAANRDPAQFEAPGEFRLDR--------------------------- 339 Query: 454 KGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYN 490 ++ FG G H C+G A ++ +L + Sbjct: 340 -AGGKGHISFGKGAHFCVGAALARLEARIVLRLLLDR 375 >3A1L-A nrPDB Length = 425 Score = 111 bits (276), Expect = 9e-25, Method: Composition-based stats. Identities = 47/354 (13%), Positives = 101/354 (28%), Gaps = 73/354 (20%) Query: 135 PNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPE 194 E + + P+I E + + + G Sbjct: 102 DPPHHTELRSLLTTEFSPSIVTGLRPRIAELASALLDRLRAQRRPDLVEG----FAAPLP 157 Query: 195 ITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKIS 254 I + +A + ++ + + A + + Y R +AA ++ + Sbjct: 158 ILVISALLGIPEEDHTWLRANAVALQEASTTRA----------RDGRGYARAEAASQEFT 207 Query: 255 ATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSAS 314 + +E+ R D L+ + G ++ I + +L G T+ + Sbjct: 208 RYFRREVDRRGGDDRDDLLTLLVRA------RDTGSPLSVDGIVGTCVHLLTAGHETTTN 261 Query: 315 TSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHM 374 A +L L + D + ++E +R Sbjct: 262 FLAKAVLTLRAHRDVLDELRTTPES----------------------TPAAVEELMRYDP 299 Query: 375 PLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKA 434 P+ ++ R +R+ ++ +P+G V+ G A+ F +P+ D R Sbjct: 300 PVQAVTRWAYEDIRL--GDHDIPRGSRVVALLGSANRDPARFPDPDVLDVHR-------- 349 Query: 435 NSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFV 488 + + FG G H C+G A + L + Sbjct: 350 ---------------------AAERQVGFGLGIHYCLGATLARAEAEIGLRALL 382 >6DCD-A nrPDB Length = 424 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 48/239 (20%), Positives = 82/239 (34%), Gaps = 57/239 (23%) Query: 253 ISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTS 312 + + I+ RR + P D++ + L +TY DG ++ + GQ T+ Sbjct: 203 LDDKFSAYIEDRRRQ----PRNDVLTA-LATATYPDGSTPEVIDVVRSATFLFAAGQETT 257 Query: 313 ASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRM 372 A + LG++P +Q + E+ +P N I+E+LRM Sbjct: 258 AKLLTAAMRVLGDRPDIQRRLR-------------------ENRSLIP---NFIEESLRM 295 Query: 373 HMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAA 432 P+ S R + + G V+V PG A+ R F++P +F R Sbjct: 296 DSPVKSDSRLARKRTTV--GGLDIAAGTVVMVLPGAANRDPRRFEDPHEFRLDR------ 347 Query: 433 KANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL 491 ++ F G H C G A V+ L + + Sbjct: 348 ----------------------PNVREHMAFARGVHSCPGGPLARVEGRVSLERILDRM 384 >1UE8-A nrPDB Length = 367 Score = 110 bits (274), Expect = 2e-24, Method: Composition-based stats. Identities = 40/240 (16%), Positives = 76/240 (31%), Gaps = 60/240 (25%) Query: 253 ISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTS 312 I Y++ I ++ D ++++D + +++ E I +++ G T+ Sbjct: 160 IGRKYLELISFSKKELDSRKGKEIVDL----TGKIANSNLSELEKEGYFILLMIAGNETT 215 Query: 313 ASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRM 372 + L+ D D + ++E LR Sbjct: 216 TN-------------------------LIGNAIEDFTLYNSWDYVREKGALKAVEEALRF 250 Query: 373 HMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAA 432 P+ R ++I + ++ +G V V A+ E F +P+ F P R Sbjct: 251 SPPVMRTIRVTKEKVKI--RDQVIDEGELVRVWIASANRDEEVFKDPDSFIPDR------ 302 Query: 433 KANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLR 492 +P+L FG G H C+G A ++ L F R Sbjct: 303 -----------------------TPNPHLSFGSGIHLCLGAPLARLEARIALEEFAKKFR 339 >6B11-A nrPDB Length = 440 Score = 109 bits (273), Expect = 2e-24, Method: Composition-based stats. Identities = 40/255 (15%), Positives = 81/255 (31%), Gaps = 61/255 (23%) Query: 267 RGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEK 326 + + ++ S++ + G ++ ++ + + +L G T+AS +L L + Sbjct: 242 KTGRESGDGMLGSMVAQAR---GGGLSHADVLDNAVLLLAAGHETTASMVTMSVLVLLQH 298 Query: 327 PHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNP 386 P + + LP + E LR + R T Sbjct: 299 PTAWRELTV-------------------NPGLLP---GAVDELLRYLSIADGLRRSATAD 336 Query: 387 LRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVD 446 + I + + G ++ A+ E F PE FD R Sbjct: 337 IEID--GHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHR-------------------- 374 Query: 447 YGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYS 506 + ++ FG G H+C+G+ A ++L L + L P D + Sbjct: 375 ---------SARRHVAFGYGPHQCLGQNLARMELEVALGAVLERL-----PALRPTTDVA 420 Query: 507 SMVVLPTEPAEIIWE 521 + + ++E Sbjct: 421 GLRLKSDSAVFGVYE 435 >4Z5Q-A nrPDB Length = 423 Score = 109 bits (272), Expect = 3e-24, Method: Composition-based stats. Identities = 75/466 (16%), Positives = 134/466 (28%), Gaps = 95/466 (20%) Query: 34 NLVWQYLYSLRKDRAPLVFYWIPWFGS-AASYGQQPYEFFESCRQKYGDVFSFML-LGKI 91 NL +Q + + + P P+ GS Q + FE GD L G+ Sbjct: 18 NLYFQSMSTEVETEKP-APVAYPFTGSEGLELSQSYAKLFED-----GDPIRVQLPFGEP 71 Query: 92 MTVYLGPKGHEFVFNAKLSDVS-AEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFAL 150 + FV + A + TP I + A Sbjct: 72 AWLVTRYDDARFVLTDRRFSRHLATQRDEPRMTPRAVPESILTMDPPDHTRLRTLVSKAF 131 Query: 151 TTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDE-- 208 T + I E ++ + G + +T+ + D+ Sbjct: 132 TPRRIESKRAWIGELAAGLVADMKAGGAPAELVGSYALAI---PVTVICELLGVPEDDRT 188 Query: 209 -MRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRER 267 +R D + + ++ + + +K RR Sbjct: 189 RLRGWCDAALSTGELTDEECVQSF-------------------MDLQKYFEDLVKERRAE 229 Query: 268 GDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKP 327 P DL +L+ D ++ + E+ L I IL+GG T+AS + F+ L ++ Sbjct: 230 ----PRDDLTSALIEARDAHD--RLAEPELIGLCISILIGGFETTASEISSFVHVLQQRR 283 Query: 328 HLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLH--SIFRKVTN 385 L + D + +P ++E LR R Sbjct: 284 ELWTRLCA-------------------DPEAIP---AAVEELLRFVPFAANGISPRYALE 321 Query: 386 PLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEV 445 + + +V +G V+V + FDN ++ R Sbjct: 322 DMTV--GGVLVREGEPVIVDTSAVNRDGLVFDNADEVVIDR------------------- 360 Query: 446 DYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL 491 + ++ FG G H C+G A V+L L V + Sbjct: 361 ----------ADNRHMVFGHGAHHCLGAHLARVELQEALKALVEGM 396 >6HQD-A nrPDB Length = 420 Score = 108 bits (269), Expect = 7e-24, Method: Composition-based stats. Identities = 47/282 (16%), Positives = 88/282 (31%), Gaps = 60/282 (21%) Query: 236 PNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQ 295 P L W + ++ Y + + + R+ P DLI L +D +T Sbjct: 193 PGYGLVDSWEQRESELMECLAYFQRLYAERQAMPPKP--DLISMLAHSPEMQD---LTPT 247 Query: 296 EIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYED 355 + L +++GG T+ S+ + + P QE ++ + Sbjct: 248 DFLGTLALLIVGGNDTTRSSMSGSAMACHLYP-------QEFDKVRNNRA---------- 290 Query: 356 LQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERY 415 + + I E +R P+ + R + + KG V++ + + Sbjct: 291 -----LLASVIPEVVRWQTPIAHMRRTALEDVEF--RGKQIRKGDKVVMWYLSGNRDDEV 343 Query: 416 FDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQF 475 D P DF R + +L FG G HRC+G + Sbjct: 344 IDRPMDFIADR----------------------------PRARHHLSFGFGIHRCLGNRL 375 Query: 476 AYVQLGTILTTFVYNLRWTI---DGYKVPDPDYSSMVVLPTE 514 A +QL + + +VP + +P Sbjct: 376 AELQLKILWEEMCERYSRIEVCGEPVRVPSNLVHGYIDIPVR 417 >5LIV-A nrPDB Length = 450 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 58/382 (15%), Positives = 115/382 (30%), Gaps = 79/382 (20%) Query: 129 GVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANV 188 G + ++ + +Y + I V + K + ++ Sbjct: 121 GGLAAMQGDEHARMRRVYNMFFLPRAVSQYEERFVRPISEQVVDRLAGKPR------VDL 174 Query: 189 MKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDA 248 ++ + RR+ F L + + + L H A Sbjct: 175 LEDFA------------MELPRRVIGELFGFPAEKLHETDERVRAMLRGLVRMHDPAAVA 222 Query: 249 AQKKISATYMKEIKSRRERGDIDPNRDLIDSLL--IHSTYKDGVKMTDQEIANLLIGILM 306 ++ + I ER D + L+ +L + + + D ++ + Q +++ +++ Sbjct: 223 ESQRAYGETLGLITEVVERESRDTSDTLLGEILRTLKAEHMDTIEASRQ----IVLSLIL 278 Query: 307 GGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTI 366 GG T++ A + L P + Q D LP I Sbjct: 279 GGYETTSWLVANTIHALLAHPDTLARVRQ-------------------DPSLLP---AAI 316 Query: 367 KETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTR 426 +E +R + R V +R+ + + G V ++ + E + +PE +D R Sbjct: 317 EEGMRWCPSSFGVLRMVERDVRLDDQ--ALSAGTVVCLAGIAGNYDETAYPSPEVYDIDR 374 Query: 427 WDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTT 486 AA FGGG H C+G A ++ L Sbjct: 375 KPLPAANV----------------------------FGGGAHFCVGAPLARMEARVGLQA 406 Query: 487 FVYNLRWTIDGYKVPDPDYSSM 508 + VP+ S M Sbjct: 407 LLARF---PGLRAVPEERPSFM 425 >2UUQ-A nrPDB Length = 414 Score = 106 bits (263), Expect = 3e-23, Method: Composition-based stats. Identities = 63/363 (17%), Positives = 105/363 (28%), Gaps = 86/363 (23%) Query: 134 CPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQP 193 E +K T + P +R+ ++ E + V + K P Sbjct: 99 QDPPVHTEFRKLVSRGFTPRQVETVEPTVRKFVVERL---EKLRANGGGDIVTELFKPLP 155 Query: 194 EITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINF-----VFPNLPLPHYWRRDA 248 + + A ++ +T + V N Sbjct: 156 SMVV--------------------AHYLGVPEEDWTQFDGWTQAIVAANAVDGATTGALD 195 Query: 249 AQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGG 308 A + A + I+ RR P D I L+ DG I ++ GG Sbjct: 196 AVGSMMAYFTGLIERRRTE----PADDAISHLVAAGVGADGDTAGTLSILAFTFTMVTGG 251 Query: 309 QHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKE 368 T + L +P D L +D + +P + ++E Sbjct: 252 NDTVTGMLGGSMPLLHRRP-------------------DQRRLLLDDPEGIP---DAVEE 289 Query: 369 TLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYF-DNPEDFDPTRW 427 LR+ P+ + R T + I +T +P G VL+ G A+ ER + + + D TR Sbjct: 290 LLRLTSPVQGLARTTTRDVTIGDT--TIPAGRRVLLLYGSANRDERQYGPDAAELDVTR- 346 Query: 428 DTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTF 487 L F G H C+G A +Q LT Sbjct: 347 ----------------------------CPRNILTFSHGAHHCLGAAAARMQCRVALTEL 378 Query: 488 VYN 490 + Sbjct: 379 LAR 381 >6F88-A nrPDB Length = 400 Score = 105 bits (262), Expect = 4e-23, Method: Composition-based stats. Identities = 58/382 (15%), Positives = 115/382 (30%), Gaps = 79/382 (20%) Query: 129 GVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANV 188 G + ++ + +Y + I V + K + ++ Sbjct: 71 GGLAAMQGDEHARMRRVYNMFFLPRAVSQYEERFVRPISEQVVDRLAGKPR------VDL 124 Query: 189 MKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDA 248 ++ + RR+ F L + + + L H A Sbjct: 125 LEDFA------------MELPRRVIGELFGFPAEKLHETDERVRAMLRGLVRMHDPAAVA 172 Query: 249 AQKKISATYMKEIKSRRERGDIDPNRDLIDSLL--IHSTYKDGVKMTDQEIANLLIGILM 306 ++ + I ER D + L+ +L + + + D ++ + Q +++ +++ Sbjct: 173 ESQRAYGETLGLITEVVERESRDTSDTLLGEILRTLKAEHMDTIEASRQ----IVLSLIL 228 Query: 307 GGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTI 366 GG T++ A + L P + Q D LP I Sbjct: 229 GGYETTSWLVANTIHALLAHPDTLARVRQ-------------------DPSLLP---AAI 266 Query: 367 KETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTR 426 +E +R + R V +R+ + + G V ++ + E + +PE +D R Sbjct: 267 EEGMRWCPSNFGVLRMVERDVRLDDQ--ALSAGTVVCLAGIAGNYDETAYPSPEVYDIDR 324 Query: 427 WDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTT 486 AA FGGG H C+G A ++ L Sbjct: 325 KPLPAANV----------------------------FGGGAHFCVGAPLARMEARVGLQA 356 Query: 487 FVYNLRWTIDGYKVPDPDYSSM 508 + VP+ S M Sbjct: 357 LLARF---PGLRAVPEERPSFM 375 >3WEC-A nrPDB Length = 419 Score = 105 bits (262), Expect = 4e-23, Method: Composition-based stats. Identities = 74/445 (16%), Positives = 132/445 (29%), Gaps = 97/445 (21%) Query: 63 SYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLS--DVSAEDAYKH 120 ++ PY + R + + L + + V ++L D + + H Sbjct: 21 TFKADPYPVYARLRTEL-PIHRSALGAW---IVADYTSCDKVLRSRLFGKDFANSTFFDH 76 Query: 121 LTT-------PVFGKGVIYDC------PNSRLMEQKKFAKFALTTDSFKRYVPKIREEIL 167 LT+ P G G+ D + A T + + + +L Sbjct: 77 LTSMMGEDMPPFLGLGIDGDARPFMLTDPPEHTRLRGLVSDAFTRSTTTS----MDDIVL 132 Query: 168 NYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKG 227 + + L+ T V+ V + P + +S D+ R F +S+L G Sbjct: 133 S-AASSAVRHLEHCTDAVSEVAEPFPVEVL--SSILGIPDKDRGRFSE-----WSNLVAG 184 Query: 228 FTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYK 287 INF P ++ A ++ +A R + L+ L Sbjct: 185 VLDINFAIP---------KEVADRRSAAIEESIDYFRTLATSGNAPEGLVRRL--SEVSH 233 Query: 288 DGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGD 347 G +++ EIA + I + GQ T+++T L+ + + Sbjct: 234 GGDQLSVDEIAATCLLITVAGQETTSNTIGNMLITFSRHADQFEQVRANPQ--------- 284 Query: 348 LNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPG 407 + N + E LR P H R + N + KG V+V Sbjct: 285 -------------FIENAVAEVLRFEPPAHEAGRIALEDCEVSGAN--ITKGDAVMVLLA 329 Query: 408 YAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGR 467 + + + F TR D ++ L +G G Sbjct: 330 SGNR--EAVERGDTFSVTRPDVSS-----------------------------LSYGRGI 358 Query: 468 HRCIGEQFAYVQLGTILTTFVYNLR 492 H C+G A L L R Sbjct: 359 HHCLGSALANSMLQHFLRELSQRYR 383 >6F0B-A nrPDB Length = 395 Score = 105 bits (262), Expect = 5e-23, Method: Composition-based stats. Identities = 46/242 (19%), Positives = 89/242 (36%), Gaps = 56/242 (23%) Query: 251 KKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQH 310 ++ T + I + P LI L+ + ++T E +++ +++GG Sbjct: 179 AEVFRTLGEYIGGLVQDPSELPEDSLIRRLVTGPYQEK--QLTFHETIGVILMLIVGGYD 236 Query: 311 TSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETL 370 T+AST + L+ +P V+++ +++P + ++E L Sbjct: 237 TTASTISLSLVSYALQPEKFSVVHEH-------------------PERIPLL---VEELL 274 Query: 371 RMHMPLH-SIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDT 429 R H + R T + + V G V+ + A+ E F NP++ D R Sbjct: 275 RYHTVSQLGLGRIATEDVEV--GGVTVRAGQMVVAALPLANRDESVFPNPDELDFDR--- 329 Query: 430 AAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVY 489 S P++ FG G H+C+G+ A V+L + + Sbjct: 330 --------------------------PSVPHVGFGYGPHQCVGQALARVELQEAIPAVIR 363 Query: 490 NL 491 L Sbjct: 364 RL 365 >3P3Z-A nrPDB Length = 416 Score = 105 bits (261), Expect = 6e-23, Method: Composition-based stats. Identities = 55/359 (15%), Positives = 97/359 (27%), Gaps = 76/359 (21%) Query: 135 PNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPE 194 + + A T P +R + + G + ++ P Sbjct: 104 DGADHRRLRGLATHPFTPRRITAVQPFVRSTVEQLI--------DKLPQGDFDFVQHFPH 155 Query: 195 ITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKIS 254 L G F D + + L L + ++ Sbjct: 156 PLPALVMCQLLG----------FPLEDYDTVGRLSIETNL--GLALSNDQDILVKVEQGL 203 Query: 255 ATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSAS 314 + + E+ ++P DL ++ + DGV + D E+ L+ +L+ G T+ Sbjct: 204 GRMFDYLVAAIEKRKVEPGDDLTSDIVRA--FHDGV-LDDYELRTLVATVLVAGYETTNH 260 Query: 315 TSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHM 374 A + + P I + ++E LR Sbjct: 261 QLALAMYDFAQHPDQWMKIKENPE----------------------LAPQAVEEVLRWSP 298 Query: 375 PLHSI-FRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAK 433 L R + +P G V + AH R F + + FD T A Sbjct: 299 TLPVTATRVAAEDFEV--NGVRIPTGTPVFMCAHVAHRDPRVFADADRFDITVKREA--- 353 Query: 434 ANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLR 492 P + FGGG H C+G A ++L + L Sbjct: 354 -------------------------PSIAFGGGPHFCLGTALARLELTEAVAALATRLD 387 >5FOI-A nrPDB Length = 408 Score = 104 bits (259), Expect = 1e-22, Method: Composition-based stats. Identities = 37/249 (14%), Positives = 75/249 (30%), Gaps = 55/249 (22%) Query: 242 HYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLL 301 D ++ + P+ L+ + + K ++T QE+ N Sbjct: 184 ASRPNDDRSMPALIELVEYLDGLVRTKTAHPDTGLLGTAVTERLLKG--EITHQELVNNA 241 Query: 302 IGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPS 361 + +L G TSA+ +L L P + ++ Sbjct: 242 VLLLAAGHETSANQVTLSVLTLLRHPETAAELREQPE----------------------L 279 Query: 362 VNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPED 421 + N + E LR H + R T + + ++ + G +++ A+ F Sbjct: 280 MPNAVDELLRYHSIADGLRRAATADIVL--GDHTIRAGDGLIILLSSANHDGNTFGAEAT 337 Query: 422 FDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLG 481 FD R + ++ FG G H+C+G+ A +++ Sbjct: 338 FDIHR-----------------------------PARHHVAFGYGPHQCLGQNLARLEME 368 Query: 482 TILTTFVYN 490 L Sbjct: 369 VTLGKLFRR 377 >4DO1-A nrPDB Length = 410 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 69/455 (15%), Positives = 135/455 (29%), Gaps = 97/455 (21%) Query: 47 RAPLVFYWIPWFG---SAASYGQQPYEFFESCRQKYGDVF---SFMLLG-----KIMTVY 95 AP IP + + PY ++ R G V + + G ++ V Sbjct: 11 SAPPNDSTIPHLAIDPFSLDFFDDPYPDQQTLRDA-GPVVYLDKWNVYGVARYAEVHAVL 69 Query: 96 LGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSF 155 P LSD E ++ + +I + + L+ + Sbjct: 70 NDPTTFCSSRGVGLSDFKKEKPWRPPS-------LILEADPPAHTRPRAVLSKVLSPATM 122 Query: 156 KRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDR 215 K +A++ + P S+F D M + Sbjct: 123 KTIRDGFAAAADAKVDELLQRGC---IDAIADLAEAYP--------LSVFPDAMGLKQEG 171 Query: 216 SFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRD 275 + P + N P R A ++ SA + + + +R ++ P Sbjct: 172 R---------EHLLPYAGLVFNAFGPPNELRQTAIER-SAPHQAYVNEQCQRPNLAPG-- 219 Query: 276 LIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQ 335 + D ++T E L+ +L G T+ + + L P + Sbjct: 220 --GFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTTVNGIGAAVYCLARFPGELQRLRS 277 Query: 336 EVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYI 395 + N +E +R P+ + FR T + + + Sbjct: 278 DPT----------------------LARNAFEEAVRFESPVQTFFRTTTREVEL--GGAV 313 Query: 396 VPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKG 455 + +G VL+ G A+ R + +P+ +D TR Sbjct: 314 IGEGEKVLMFLGSANRDPRRWSDPDLYDITR----------------------------- 344 Query: 456 VSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYN 490 +S ++ FG G H C+G+ A ++ +L+ Sbjct: 345 KTSGHVGFGSGVHMCVGQLVARLEGEVMLSALARK 379 >3TYW-A nrPDB Length = 417 Score = 102 bits (254), Expect = 4e-22, Method: Composition-based stats. Identities = 58/357 (16%), Positives = 103/357 (28%), Gaps = 80/357 (22%) Query: 135 PNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPE 194 ++ A T + P ++ + DE G +++ Sbjct: 103 DAPEHTRYRRMLLPAFTVRRVRAMRPAVQARV------DEILDGMLAAGGPVDLVSAYAN 156 Query: 195 ITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKIS 254 + L G D F + + + + A + Sbjct: 157 AVSTSVICELLG---IPRHDLEFFRDVTRISGSRNSTA-----------EQVSEALGGLF 202 Query: 255 ATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSAS 314 + RRE P DLI L+ V T +++ + L + G+ T+ S Sbjct: 203 GLLGGLVAERREE----PRDDLISKLVTDHLVPGNV--TTEQLLSTLGITINAGRETTTS 256 Query: 315 TSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHM 374 A L L ++P L + + D +P + E LR+ Sbjct: 257 MIALSTLLLLDRPELPAELRK-------------------DPDLMP---AAVDELLRVLS 294 Query: 375 PLHSIF-RKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAK 433 SI R + + VP V+ A+ FD+PE D R Sbjct: 295 VADSIPLRVAAEDIELSGR--TVPADDGVIALLAGANHDPEQFDDPERVDFHR------- 345 Query: 434 ANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYN 490 + ++ FG G H+C+G+ A ++L L T + Sbjct: 346 ----------------------TDNHHVAFGYGVHQCVGQHLARLELEVALETLLRR 380 >2WIY-A nrPDB Length = 394 Score = 101 bits (252), Expect = 6e-22, Method: Composition-based stats. Identities = 74/452 (16%), Positives = 126/452 (27%), Gaps = 82/452 (18%) Query: 54 WIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVS 113 +PW S + PY ++ +Q + V T + F AKL +S Sbjct: 10 LVPW--SDPEFRNNPYPWYRRLQQDH-PVHKLEDG----TYLVSRYADVSHF-AKLPIMS 61 Query: 114 AEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTD 173 E + ++ T +V RE + + Sbjct: 62 VEPGWADAGPWAVASDTALGSDPPHHTVLRRQTNKWFTPKLVDGWVRTTRELVGDLLDGV 121 Query: 174 ESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINF 233 E+ ++ E +A V T T +R L E D + A + + + Sbjct: 122 EAGQVIEARRDLAVVP------THVTMARVLQLPE-----DDADAVMEAMFEAMLMQSAE 170 Query: 234 VFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMT 293 P D A + E ++P L DSLL + + +T Sbjct: 171 -------PADGDVDRAAVAF-GYLSARVAEMLEDKRVNPGDGLADSLLDAARAGE---IT 219 Query: 294 DQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTY 353 + E ++ G A + +P + + Sbjct: 220 ESEAIATILVFYAVGHMAIGYLIASGIELFARRPEVFTAFRNDESAR------------- 266 Query: 354 EDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSE 413 I E +RM P S R T + I ++ G + G A+ Sbjct: 267 ---------AAIINEMVRMDPPQLSFLRFPTEDVEI--GGVLIEAGSPIRFMIGAANRDP 315 Query: 414 RYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGE 473 FD+P+ FD TR +S L FG G H C G+ Sbjct: 316 EVFDDPDVFDHTR---------------------------PPAASRNLSFGLGPHSCAGQ 348 Query: 474 QFAYVQLGTILTTFVYNLRWTIDGYKVPDPDY 505 + + T+ I+ + P + Sbjct: 349 IISRAEATTVFAVLAERYE-RIELAEEPTVAH 379 >5L1U-A nrPDB Length = 401 Score = 99.5 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 68/459 (14%), Positives = 132/459 (28%), Gaps = 102/459 (22%) Query: 77 QKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVS------AEDAYKHLTTPVFGKGV 130 QK G + G+ + + + +S + + G Sbjct: 28 QKEGPIARVGTAGEDAWLVTRYDEVRTLLADRRLRLSNPNPQPSAKSAARAFMVALAAGD 87 Query: 131 IYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYF----VTDESFKLKEKTHGVA 186 ++ +R + + +T + +I + + L Sbjct: 88 DHETEPARHAQMRSLLIPRFSTRRLRLMKTRIEHHVDELLDQLAASAPPVDLHRVLSFRL 147 Query: 187 NVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRR 246 M + + A R FG R FD+S Sbjct: 148 PTMVVCDLLGVPLADRERFGQWARGTFDQS-------------------------DNEHS 182 Query: 247 DAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILM 306 +++ ++ + +R ++P D++ L+ KDG ++D +IA+L +L+ Sbjct: 183 ANTFQQVVDYMLELVARKR----VEPGDDILSELIA---EKDG-ALSDADIAHLGNAVLL 234 Query: 307 GGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTI 366 G T+ L L P + + ED P + Sbjct: 235 FGYETTIVRIDLGTLLLLRNPVQRAQL-------------------AEDPGLAP---AAV 272 Query: 367 KETLRMHM----PLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDF 422 +E LR+ + I R + + ET ++ G V+++ G A+ +R F + F Sbjct: 273 EEILRLGVGGKGSNALIPRYAHGDITVGET--VIRTGDAVMLAIGAANYDDRAFPDGGLF 330 Query: 423 DPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGT 482 D TR +L FG G CIG A ++L Sbjct: 331 DLTR----------------------------VRPRSHLAFGHGARHCIGRTLARIELTA 362 Query: 483 ILTTFVYN---LRWTIDGYKVPDPDYSSMVVLPTEPAEI 518 + LR + + ++ P Sbjct: 363 VFERLFRRLPDLRLAVPEESLRWQEHRITGGFDEIPVTF 401 >6FYJ-A nrPDB Length = 421 Score = 99.5 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 77/465 (16%), Positives = 147/465 (31%), Gaps = 82/465 (17%) Query: 60 SAASYGQQPYEFFESCRQKY-GDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAY 118 S ++ Y + + R + D+F LLGK G + E ++ + Sbjct: 17 STWRLMEEGYMYILNRRHSFNSDIFETRLLGKKAICMGGKEAAEIFYDTEKFKRKDAAPN 76 Query: 119 KHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKL 178 + + T +FGK + +K+ ++ D ++ +++ + + ++ Sbjct: 77 RVVQT-LFGKNGVQALDGQTHKHRKEMFMSIMSPDELEKLTDITKKQWE---IAVDKWEQ 132 Query: 179 KEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNL 238 +K + A + +E++R L +L F V Sbjct: 133 MDKVILYEEAKEIMCRTACQWAGVPVQENEVKR--------LTKNLGAMFESAAAV---- 180 Query: 239 PLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIA 298 L H+ R A + +++E+ R G ++P + +G + + A Sbjct: 181 GLKHWLGRHARNYE--EIWIEELIDRVRDGKVNPPENTTLHKFSWYRDLEGNLLDTETAA 238 Query: 299 NLLIGIL---MGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYED 355 +I IL + A + L L P ++ + K GD Sbjct: 239 VEVINILRPIVA----IAIFINFIALALHHYPEEKEKL----------KSGDKK------ 278 Query: 356 LQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERY 415 ++E R + + V Y +G L+ + Sbjct: 279 -----YSQMFVQEVRRFYPFFPFVVALVKKD--FTWKGYKFEEGTLTLLDLYGTNHDPEI 331 Query: 416 FDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGR----HRCI 471 + NP+ F P R+ +G ++P GGG HRC Sbjct: 332 WKNPDVFSPDRF-----------------------AKWEGSPFSFIPQGGGDYFMGHRCA 368 Query: 472 GEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYS-SMVVLPTEP 515 GE + L + Y+VPD D S SM +P+ P Sbjct: 369 GEWVTIEVMKVSLDYLTNRMD-----YEVPDQDLSFSMASMPSIP 408 >6M7L-A nrPDB Length = 404 Score = 98.8 bits (244), Expect = 5e-21, Method: Composition-based stats. Identities = 53/366 (14%), Positives = 100/366 (27%), Gaps = 91/366 (24%) Query: 128 KGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVAN 187 G + ++ A + + P+++ + ++ T S V Sbjct: 97 PGNLLQLDPPEHTRLRRMVAPAYSVRRMQALEPRVQAIVDDHLDTMASTGPP-----VEF 151 Query: 188 VMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRD 247 + + + A L P++ + L + Sbjct: 152 LREVAGPMAARVACEFL-----------------------GIPLDDRGELIRLTAHRGGK 188 Query: 248 AAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMG 307 + Y+ ++ R DP D +L G ++D+E+A L ++ Sbjct: 189 RRRVLNGHAYLAYMRELAARLRRDPG----DGMLGMVARDHGADISDEELAGLCAVVMNS 244 Query: 308 GQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIK 367 + S A L L E P ++ + ++ Sbjct: 245 SVEQTESCLAAGTLLLLEHPEQFALLRERPE----------------------LGEQAVE 282 Query: 368 ETLRMHMPLHSI-FRKVTNPLRIPETNYIVPKGHYVLVSPGYAHT-SERYFDNPEDFDPT 425 E +R + R T + I ++ KG V S A+ + FD T Sbjct: 283 EIVRYLSVFEGLDPRTATEDVEI--GGQVIKKGEAVFCSLLAANRADPAL----DGFDIT 336 Query: 426 RWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILT 485 R S ++ FG G H C+G A ++L T Sbjct: 337 R-----------------------------KESRHVAFGHGIHHCLGAPLARMELRIAFT 367 Query: 486 TFVYNL 491 T V Sbjct: 368 TLVSRF 373 >2ZQJ-A nrPDB Length = 417 Score = 98.0 bits (242), Expect = 9e-21, Method: Composition-based stats. Identities = 71/473 (15%), Positives = 145/473 (30%), Gaps = 71/473 (15%) Query: 58 FGSAASYGQQPYEFFESCRQKY-GDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAED 116 ++ + ++ Y F ++ ++Y D+F LLGK G + + ++ Sbjct: 11 LDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGKNFICMTGAEAAKVFYDTDRFQRQNAL 70 Query: 117 AYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESF 176 K + +FG I S + +K +T KR + EE + Sbjct: 71 P-KRVQKSLFGVNAIQGMDGSAHIHRKMLFLSLMTPPHQKRLAELMTEEWK---AAVTRW 126 Query: 177 KLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFP 236 + ++ + + + A L E++ D D V P Sbjct: 127 EKADEVVLFEEAKEILCRVACYWAGVPLKETEVKERAD--------DFIDMVDAFGAVGP 178 Query: 237 NLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQE 296 +W+ A+ + I+ R G + + T +DG ++ + Sbjct: 179 R-----HWKGRRARPRAEEWIEVMIEDARA-GLLKTTSGTALHEMAFHTQEDGSQLDSRM 232 Query: 297 IANLLIGILMGGQHTSASTSAWFLLH----LGEKPHLQDVIYQEVVELLKEKGGDLNDLT 352 A LI +L ++FL+ L E P ++ + G+ + Sbjct: 233 AAIELINVLRP-----IVAISYFLVFSALALHEHPKYKEWLR----------SGNSRER- 276 Query: 353 YEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTS 412 ++E R + + V + KG VL+ + Sbjct: 277 ----------EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEF--KKGTSVLLDLYGTNHD 324 Query: 413 ERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIG 472 R +D+P++F P R+ + + G HRC G Sbjct: 325 PRLWDHPDEFRPERFAEREENLFDMIPQGGGHAEKG-------------------HRCPG 365 Query: 473 EQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIWEKRET 525 E + L V+ + + + + + M LP + +R++ Sbjct: 366 EGITIEVMKASLDFLVHQIEYDVPEQSL-HYSLARMPSLPESGFVMSGIRRKS 417 >5DE9-A nrPDB Length = 410 Score = 97.2 bits (240), Expect = 2e-20, Method: Composition-based stats. Identities = 44/260 (16%), Positives = 80/260 (30%), Gaps = 66/260 (25%) Query: 247 DAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILM 306 + A+ +++A + I R + D + SLL + +D + ++ E L + + + Sbjct: 189 ERAKNEMNAYFSDLIGLRSDSAGED-----VTSLLGAAVGRDEITLS--EAVGLAVLLQI 241 Query: 307 GGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTI 366 GG + S L +P L + + E I Sbjct: 242 GG-EAVTNNSGQMFHLLLSRPELAERLRSEPEIR----------------------PRAI 278 Query: 367 KETLRMHM--PLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDP 424 E LR + R + I + G V VS A+ F +P+ D Sbjct: 279 DELLRWIPHRNAVGLSRIALEDVEI--KGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDF 336 Query: 425 TRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTIL 484 R +P++ FG G H C G A ++ ++ Sbjct: 337 ER-----------------------------SPNPHVSFGFGPHYCPGGMLARLESELLV 367 Query: 485 TTFVYN---LRWTIDGYKVP 501 + L+ + VP Sbjct: 368 DAVLDRVPGLKLAVAPEDVP 387 >5YHJ-A nrPDB Length = 413 Score = 96.9 bits (239), Expect = 2e-20, Method: Composition-based stats. Identities = 71/469 (15%), Positives = 142/469 (30%), Gaps = 69/469 (14%) Query: 58 FGSAASYGQQPYEFFESCRQKY-GDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAED 116 + + ++ Y F + R+ + ++F LLG+ + G + E ++A Sbjct: 11 LDHSVDFLREGYLFVANRRKSFQSNIFESRLLGERVICLGGEEAAEVFYDANKFTRQDAA 70 Query: 117 AYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESF 176 + L T +FG+G + S +K+ +T E I Sbjct: 71 PKRLLKT-LFGEGGVQTLDGSEHTHRKQMFMSLMTK-----------ENIDRLLRLTYRE 118 Query: 177 KLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFP 236 + + G V+ + + A G + + + L + T + Sbjct: 119 WNQIERMGEEIVLYDIAQEVLMKAVCEWSGVPLAKEEVGKRTEEMRLLFESGTSLG---- 174 Query: 237 NLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQE 296 P Y + A+ + +K R + PN + G + ++ Sbjct: 175 ----PTYLQGRKARSSAEVWIRQMVKEVR-SNRLLPNEHTALYEFSWHRDESGELLPEEV 229 Query: 297 IANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVI-YQEVVELLKEKGGDLNDLTYED 355 +A ++ IL S + +L L + P +++ + EV + Sbjct: 230 VAVEVLNILRPTVAISVYVL-FTVLALHQFPDVKEQVERGEVSKT--------------- 273 Query: 356 LQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERY 415 ++E R + +V Y P+G L+ + Sbjct: 274 --------EFVQEVRRFYPFFPVAAARVKTDFE--WDGYAFPEGTLTLLDLYGTNHDVSI 323 Query: 416 FDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQF 475 + P+ FDP+R+ + +VD FG HRC GE Sbjct: 324 WTEPDRFDPSRFKDWKESPFNFIPQGGGDVD----------------FG---HRCAGEHV 364 Query: 476 AYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIWEKRE 524 L ++ F +T+ + + M LP + R Sbjct: 365 TIAILAQVIELFTKEYAYTVPPQDL-SYSFVDMPSLPKSKLRLTHLTRN 412 >3BUJ-A nrPDB Length = 397 Score = 95.7 bits (236), Expect = 4e-20, Method: Composition-based stats. Identities = 56/350 (16%), Positives = 99/350 (28%), Gaps = 75/350 (21%) Query: 130 VIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVM 189 +I + A + + +R P I + + G +V+ Sbjct: 78 IILFQDEPDHGRLRGVVGPAFSPSALRRLEPVIAGTVDDLLRP-------ALARGAMDVV 130 Query: 190 KTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAA 249 A L G + + D+ + R AA Sbjct: 131 DELAYPLALRAVLGLLGLPAADW--GAVGRWSRDVGRTLDR------GASAEDMRRGHAA 182 Query: 250 QKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQ 309 + + + + RR G DL+ +L D M+ EI + ++ + G Sbjct: 183 IAEFADYVERALARRRREG----GEDLLALML---DAHDRGLMSRNEIVSTVVTFIFTGH 235 Query: 310 HTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKET 369 T AS +L L P D++ + + ++E Sbjct: 236 ETVASQVGNAVLSLLAHPDQLDLLRRRPD----------------------LLAQAVEEC 273 Query: 370 LRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDT 429 LR + S R++ + + + V+V G A+ R +D P+DFD R Sbjct: 274 LRYDPSVQSNTRQLDVDVELRGRRLR--RDDVVVVLAGAANRDPRRYDRPDDFDIER--- 328 Query: 430 AAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQ 479 P + FG G C+G A Q Sbjct: 329 --------------------------DPVPSMSFGAGMRYCLGSYLARTQ 352 >6BLD-A nrPDB Length = 419 Score = 95.3 bits (235), Expect = 5e-20, Method: Composition-based stats. Identities = 58/374 (15%), Positives = 108/374 (28%), Gaps = 71/374 (18%) Query: 131 IYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMK 190 R + +K A T +R I+ +L+ GV V Sbjct: 102 FLAMDPPRHTKLRKLVSAAFTPRQVRRIEDSIKINAKGIVD-----ELRMAGGGVDFVEH 156 Query: 191 TQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQ 250 E+ I T S +M I + ++ D + + P R A Sbjct: 157 CAKELPIRTLS------DMVGIPEADRERVAHAADALVSWAD------PRYLNGREPLAV 204 Query: 251 KKISATYMKEIKSRRERGDID-PNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQ 309 + Y+ ++ + D P DL +L+ DG ++ D ++A + + + G Sbjct: 205 LFENQMYLHQVAASLAAERRDRPGDDLFSALVNAEV--DGDRLADADVAAFFVLLAVAGN 262 Query: 310 HTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKET 369 T+ T + L L + P + + + + ++E Sbjct: 263 DTTRQTISHGLKALTDFPSQKAWLLADFDTRIGT---------------------AVEEL 301 Query: 370 LRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDT 429 +R P+ + R + ++ G V++ + E F +PE D +R Sbjct: 302 VRWATPVMTFRRTAAADFEL--GGQLIRAGEKVVMFYASGNWDEDAFCHPERLDLSRSPN 359 Query: 430 AAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVY 489 + C+G A QL I + Sbjct: 360 PHVGFGGGGVHF----------------------------CLGAHLARAQLRAIFGELLV 391 Query: 490 NLRWTIDGYKVPDP 503 L G V P Sbjct: 392 QLPDIQAGDPVYVP 405 >6G71-A nrPDB Length = 405 Score = 94.9 bits (234), Expect = 7e-20, Method: Composition-based stats. Identities = 69/440 (15%), Positives = 133/440 (30%), Gaps = 92/440 (20%) Query: 60 SAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTV----YLGPKGHEFVFNAKLSDVSAE 115 A Q P+ FE R + V G+ + L + F+A Sbjct: 15 HLADLYQNPFPIFERLRSE-SPVAWVPEAGRYLITSYSGVLAADVDQTTFSANEKKSLML 73 Query: 116 DAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKR-YVPKIREEILNYFVTDE 174 A H + +++ + +L + K+ + K E Y Sbjct: 74 RAMGHSMLR---------KDDPDHQVERRAWQPSLKPGTVKKVWKQKFAENADRYLDAYI 124 Query: 175 SFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFD-RSFAQLYSDLDKGFTPINF 233 + G ++ M+ + R+L G E D + ++Q D Sbjct: 125 -----DAGSG-SDFMQGFAAPFVAENLRALIGFENASEADLQRWSQTLIDGAGN------ 172 Query: 234 VFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMT 293 +P+ P + + + +I A + I+ R P L+ LL + Y +M Sbjct: 173 -YPDDP-DVWAKAKQSSDEIDAALEEMIQWHSGR----PGDSLLSYLLRSADY----QMP 222 Query: 294 DQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTY 353 + I + + + GG + L L +++ Sbjct: 223 LESIRSNIKMTIGGGLNEPRDVLGVSTLALLSSSKQLELV-------------------- 262 Query: 354 EDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSE 413 L+ +E++R P+ + R+ + Y +P+G + + A+ Sbjct: 263 --LRDPKLWGAVFEESIRWVAPIGMVPRQTVVDTELD--GYFIPRGAKLGLCILSANRDR 318 Query: 414 RYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGE 473 + +P+ FD R S +L FG G H C+G Sbjct: 319 SVWSDPDRFDIER-----------------------------GSEAHLAFGKGVHVCLGA 349 Query: 474 QFAYVQLGTI-LTTFVYNLR 492 A Q+ + L L+ Sbjct: 350 WAARSQVADVGLPALFSRLK 369 >5OMS-A nrPDB Length = 409 Score = 94.9 bits (234), Expect = 8e-20, Method: Composition-based stats. Identities = 74/430 (17%), Positives = 121/430 (28%), Gaps = 72/430 (16%) Query: 61 AASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKH 120 + PYE +E R + + +LG + V + E Sbjct: 19 MTQLERNPYEVYERLRAE-APLAFVPVLGSYVA------STAEVCREVATSPDFEAVITP 71 Query: 121 LTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKE 180 FG I + + + AL R++ + I ++ Sbjct: 72 AGGRTFGHPAIIGVNGDIHADLRSMVEPALQPAEVDRWIDDLVRPIARRYLERFENDGHA 131 Query: 181 KTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPL 240 + + + + + D++R FA+L N F N Sbjct: 132 ELVAQYCEPVSVRSLGDLLGLQEVDSDKLREW----FAKLNRSFTNAAVDENGEFANP-- 185 Query: 241 PHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANL 300 + D A+ +I A I E P+ I L H G + I Sbjct: 186 EGFAEGDQAKAEIRAVVDPLIDKWIEH----PDDSAISHWL-HDGMPPGQTRDREYIYPT 240 Query: 301 LIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLP 360 + L+G A L+ L +P + + +D +P Sbjct: 241 IYVYLLGAMQEPGHGMASTLVGLFSRPEQLEEV-------------------VDDPTLIP 281 Query: 361 SVNNTIKETLRMHMPLHSIF-RKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNP 419 I E LR P+ S R T P+ I +P G V++S G A+ ++ P Sbjct: 282 ---RAIAEGLRWTSPIWSATARISTKPVTI--AGVDLPAGTPVMLSYGSANHDTGKYEAP 336 Query: 420 EDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQ 479 +D R P+L FG G H C G FA Sbjct: 337 SQYDLHR-----------------------------PPLPHLAFGAGNHACAGIYFANHV 367 Query: 480 LGTILTTFVY 489 + L Sbjct: 368 MRIALEELFE 377 >2X9P-A nrPDB Length = 404 Score = 94.5 bits (233), Expect = 9e-20, Method: Composition-based stats. Identities = 47/248 (18%), Positives = 79/248 (31%), Gaps = 66/248 (26%) Query: 246 RDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGIL 305 AQ + ++ +R P D+I L + ++T+ +A+L +G+L Sbjct: 191 AVRAQDDLFGYVAGLVEHKRAE----PGPDIISRL-------NDGELTEDRVAHLAMGLL 239 Query: 306 MGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNT 365 G + AS ++ L P + + + Sbjct: 240 FAGLDSVASIMDNGVVLLAAHPDQRAAALADPD----------------------VMARA 277 Query: 366 IKETLRMHMPLHSI--FRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFD 423 ++E LR S+ R + + + G VL G + ER F PE+FD Sbjct: 278 VEEVLRTARAGGSVLPPRYASEDMEF--GGVTIRAGDLVLFDLGLPNFDERAFTGPEEFD 335 Query: 424 PTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTI 483 R +P+L FG G CIG A ++L T+ Sbjct: 336 AAR-----------------------------TPNPHLTFGHGIWHCIGAPLARLELRTM 366 Query: 484 LTTFVYNL 491 T L Sbjct: 367 FTKLFTRL 374 >5HH3-A nrPDB Length = 397 Score = 94.5 bits (233), Expect = 1e-19, Method: Composition-based stats. Identities = 62/432 (14%), Positives = 124/432 (28%), Gaps = 92/432 (21%) Query: 88 LGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAK 147 G+ + G V ++ D SA Y + G + ++ Sbjct: 50 GGRTAWLATGYDEIRQVLSS--DDFSARLLYGGTAAGITWPGFLTQYDPPEHTRLRRMVA 107 Query: 148 FALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGD 207 A +++ P++ + + E+ G + + TA+ G Sbjct: 108 PAFAVRRMQKFQPQVERVVQDSLDAIEALG------GPVDFVPRFGWSVATTATCDFLGI 161 Query: 208 EMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRER 267 D + +L R + +M + R Sbjct: 162 PRDDQAD-------------------LARSLHASRTERSGKRRTAAGNKFMTYMNKMTAR 202 Query: 268 GDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKP 327 DP D+ ++ + G ++TD E+ + ++ G A A + + P Sbjct: 203 TRRDPGDDMFGVVV----REYGDEITDAELTGVAAFVMGAGADQVARFLAAGAWLMADDP 258 Query: 328 HLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPL 387 ++ ++ + + LT ++ R T+ + Sbjct: 259 EQFALLREKPDTVPDWLDEVIRYLTTDEKTH---------------------PRVATDDV 297 Query: 388 RIPETNYIVPKGHYVLVSPGYAHTSERYFDNPED-FDPTRWDTAAAKANSVSFNSSDEVD 446 RI ++++ G V S A+ R F PED FD TR Sbjct: 298 RI--GDHLIKAGDTVTCSLLAANR--RNFPRPEDRFDITRVRPE---------------- 337 Query: 447 YGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYS 506 +L FG G H C+G A + T + + ++ +P Sbjct: 338 -------------HLAFGHGIHHCLGRSLAELVFRTAIPALAHRF----PTLRLAEP--H 378 Query: 507 SMVVLPTEPAEI 518 + L P ++ Sbjct: 379 REIRLGPPPFDV 390 >5KYO-A nrPDB Length = 430 Score = 93.4 bits (230), Expect = 2e-19, Method: Composition-based stats. Identities = 58/348 (16%), Positives = 106/348 (30%), Gaps = 66/348 (18%) Query: 176 FKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTP-INFV 234 L+ V ++ + E R F E DL P + + Sbjct: 144 KPLRPIEQVVTDLAVSLIEG-FRPKGRCNFTHEFAEQLPVRIFMRIVDLPVEDLPKLKHL 202 Query: 235 FPNLPLP-HYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMT 293 P D K+ I++RR I P D+I ++ G +T Sbjct: 203 ADQYTRPDGSIPLDDVTKQFREYLRPVIEARR----IKPGEDMISRMINGEV--GGRPLT 256 Query: 294 DQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTY 353 D E N+ I +L+GG T + + HL + L+ I + Sbjct: 257 DIEAENICIQVLVGGLDTVVNMLGFTFSHLAKDHALRRAIAADPS--------------- 301 Query: 354 EDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSE 413 +++ + E R P+ S R+V ++ G V+ + Sbjct: 302 -------LIDDALLEFFRRF-PVVSSAREVLRDQEFE--GVLLKAGDMVMAPTVVVAMDD 351 Query: 414 RYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGE 473 ++P +F R + + FG G H C G Sbjct: 352 ARNEDPLEFRLGR-----------------------------KARQHSTFGKGSHTCPGA 382 Query: 474 QFAYVQLGTILTTFVYNL-RWTIDGYKVPDPDYSSMVVLPTEPAEIIW 520 A +++ +L + + + I+ YS+ +V +P + W Sbjct: 383 HLARMEMKVVLREWFARIPEFRIEDD--APLRYSNGIVGSVKPFVLEW 428 >3OFT-A nrPDB Length = 396 Score = 91.8 bits (226), Expect = 6e-19, Method: Composition-based stats. Identities = 52/359 (14%), Positives = 94/359 (26%), Gaps = 80/359 (22%) Query: 130 VIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVM 189 + + + L + PK++ ES + + V++ Sbjct: 85 IPLQQDGAEHKAFRTPVMKGLASRFVVALEPKVQAVARKLM---ESLRPRGSCDFVSDFA 141 Query: 190 KTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAA 249 + P T D R + + L P Sbjct: 142 EILPLNIFLTLIDVPLEDRPR--------------------LRQLGVQLTRPDGSMTVEQ 181 Query: 250 QKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQ 309 K+ + Y+ +R P DL +L S G T E + +L GG Sbjct: 182 LKQAADDYLWPFIEKR---MAQPGDDLFSRIL--SEPVGGRPWTVDEARRMCRNLLFGGL 236 Query: 310 HTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKET 369 T A+ LHL P Q ++ + + E Sbjct: 237 DTVAAMIGMVALHLARHPEDQRLLRERPD----------------------LIPAAADEL 274 Query: 370 LRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDT 429 +R + P ++ R + + KG V + + F+ PE+ R Sbjct: 275 MRRY-PTVAVSRNAVAD--VDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDRGLA 331 Query: 430 AAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFV 488 + G G HRC+G A +++ L ++ Sbjct: 332 PI---------------------------RHTTMGVGAHRCVGAGLARMEVIVFLREWL 363 >5HIW-A nrPDB Length = 398 Score = 90.7 bits (223), Expect = 1e-18, Method: Composition-based stats. Identities = 61/385 (15%), Positives = 110/385 (28%), Gaps = 75/385 (19%) Query: 107 AKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEI 166 A L D + T + KG + ++ L+ RY + Sbjct: 50 AVLRDSETFSTRTYDTGIM--KGALVTLGGEAHTRMRRLFNAVLSPRVISRYEEATVTPV 107 Query: 167 LNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDK 226 V E KE+ + + P T++ +E D L + + Sbjct: 108 ARRVV--ERLVRKERAELFDDFAISMPMGV--TSALFGLPEERIAENDA----LIRKMIR 159 Query: 227 GFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTY 286 V P P+ R A A +++ ER P+ L+ + Sbjct: 160 SV-----VMPQDPVVVAEGRSA-----HAAMEAQLREIAEREVAHPSDTLLGEIARAIVA 209 Query: 287 KDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGG 346 + + E +++ +++G T++ A L+ L P + + Q+ Sbjct: 210 EGLGGVEACE--GVVLTLILGSYETTSWMLANLLVALLAHPDAMNQLRQQPS-------- 259 Query: 347 DLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSP 406 + I+E+ R I R V I + G + +S Sbjct: 260 --------------LLPQAIEESTRWCSSAAGIVRFVEREATI--GGETLAAGTILYLSL 303 Query: 407 GYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGG 466 H E + PE FD R L FGGG Sbjct: 304 IARHYDEEIYPRPETFDIHR-----------------------------RPVGMLNFGGG 334 Query: 467 RHRCIGEQFAYVQLGTILTTFVYNL 491 H C+G A ++ ++ + Sbjct: 335 LHYCVGAPLARMEARVGVSLLLERF 359 >3AWQ-A nrPDB Length = 415 Score = 90.3 bits (222), Expect = 2e-18, Method: Composition-based stats. Identities = 66/480 (13%), Positives = 133/480 (27%), Gaps = 102/480 (21%) Query: 60 SAASYGQQPYEFFESCRQKYG-DVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAY 118 S PY F Q+ G + F L K G K E ++ + Sbjct: 12 ETLSLLADPYRFISRQCQRLGANAFESRFLLKKTNCLKGAKAAEIFYDTTRFEREGAMPV 71 Query: 119 KHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKL 178 + +FG+G + +K+ +T + + E Sbjct: 72 A-IQKTLFGQGGVQGLDGETHRHRKQMFMGLMTPERVRALAQLFEAEWRRAV-------P 123 Query: 179 KEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNL 238 G +F DE L + T + + Sbjct: 124 GWTRKGEI-----------------VFYDE---------------LHEPLTRAVCAWAGV 151 Query: 239 PLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIA 298 PLP + E+++ + R L L ++ I Sbjct: 152 PLP---------DDEAGNRAGELRALFDAAGSASPRHLWSRLARRRVDAWAKRI----IE 198 Query: 299 NLLIGILMGGQHTSASTSAWFL---------------LHLGEKPHLQDVIYQEVVELLKE 343 + G + G T+A AW L +P + +Y + + Sbjct: 199 GIRAGSIGSGSGTAAYAIAWHRDRHDDLLSPHVAAVELVNVLRPTVAIAVY---ITFVAH 255 Query: 344 KGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVL 403 + + +Q+ ++E R + ++ + + + P+G V+ Sbjct: 256 ALQTCSGIRAALVQQPDYAELFVQEVRRFYPFFPAVVARASQDFEWEGMAF--PEGRQVV 313 Query: 404 VSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPF 463 + ++ + +P++F P R+ + S ++P Sbjct: 314 LDLYGSNHDAATWADPQEFRPERF-----------------------RAWDEDSFNFIPQ 350 Query: 464 GGGR----HRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEII 519 GGG HRC GE + V +R+ + + D++ + LP + Sbjct: 351 GGGDHYLGHRCPGEWIVLAIMKVAAHLLVNAMRYDVPDQDL-SIDFARLPALPKSGFVMR 409 >5EX8-A nrPDB Length = 424 Score = 89.1 bits (219), Expect = 4e-18, Method: Composition-based stats. Identities = 60/410 (14%), Positives = 115/410 (28%), Gaps = 90/410 (21%) Query: 110 SDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNY 169 SA Y + G + ++ A + +++ P++ + + + Sbjct: 97 DKFSARLLYGGTAAGITWPGFLTQYDPPEHTRLRRMVVPAFSHRRMQKFRPRVEQIVQDS 156 Query: 170 FVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFT 229 T ES G + + A+ G D + L S D Sbjct: 157 LDTIESLG------GPVDFVPHFGWAIATPATCDFLGIPRDDQADLARILLASRTD---- 206 Query: 230 PINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDG 289 R D + +M +K + DL + ++G Sbjct: 207 ---------------RSDKRRTAAGNKFMTYMKQHVAQSRRGSGDDLFGIV----GRENG 247 Query: 290 VKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLN 349 +TD E+ + ++ A A + E+P ++ ++ + + Sbjct: 248 DAITDAELTGVAAFVMGAAADQVARLLAAGAWLMVEQPAQFALLREKPETVPEW------ 301 Query: 350 DLTYEDLQKLPSVNNTIKETLRMHMPLHSI-FRKVTNPLRIPETNYIVPKGHYVLVSPGY 408 + ET+R R T +RI N +V G V S Sbjct: 302 ----------------LDETMRYLTTDEKTHPRVATQDVRI--GNQLVKAGDTVTCSLLA 343 Query: 409 AHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRH 468 A+ Y ++FD TR + +L FG G H Sbjct: 344 ANR-PNYPSAEDEFDITR-----------------------------EKAEHLAFGHGIH 373 Query: 469 RCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEI 518 C+G A + + + ++ DP + L P ++ Sbjct: 374 HCLGRAMAELMFKVSIPALAHRF----PTLRLADPQRE--ITLGPPPFDV 417 >4FB2-A nrPDB Length = 398 Score = 88.4 bits (217), Expect = 7e-18, Method: Composition-based stats. Identities = 61/436 (13%), Positives = 134/436 (30%), Gaps = 87/436 (19%) Query: 67 QPYEFFESCRQK--YGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAYKHLTTP 124 P+ FFE+ R + + G V G K + V + + + T Sbjct: 20 TPHAFFEALRDEAETTPIGWSEAYGGHWVVA-GYKEIQAVIQNTKAFSNKGVTFPRYETG 78 Query: 125 VFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHG 184 F + ++ + + ++ + ++ + ++R+ + + Sbjct: 79 EF-ELMMAGQDDPVHKKYRQLVAKPFSPEATDLFTEQLRQSTNDLIDARIELGEGDAATW 137 Query: 185 VANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYW 244 +AN + + I GD RR V+ + + Sbjct: 138 LANEIPARLT-AILLGLPPEDGDTYRRW---------------------VWAITHVENPE 175 Query: 245 RRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGI 304 ++ A I RR +P D++ ++ + DG +++ ++ + Sbjct: 176 EGAEIFAELVAHARTLIAERR----TNPGNDIMSRVI--MSKIDGESLSEDDLIGFFTIL 229 Query: 305 LMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNN 364 L+GG +A + L L+ + + + N Sbjct: 230 LLGGIDNTARFLSSVFWRLAWDIELRRRL----------------------IAHPELIPN 267 Query: 365 TIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDP 424 + E LR + P + R VT + + + + G ++ A FD+P++ Sbjct: 268 AVDELLRFYGPA-MVGRLVTQEVTV--GDITMKPGQTAMLWFPIASRDRSAFDSPDNIVI 324 Query: 425 TRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTIL 484 R + +L G G HRC+G V+ + Sbjct: 325 ER-----------------------------TPNRHLSLGHGIHRCLGAHLIRVEARVAI 355 Query: 485 TTFVYNL-RWTIDGYK 499 T F+ + +++D K Sbjct: 356 TEFLKRIPEFSLDPNK 371 >3OO3-A nrPDB Length = 384 Score = 84.9 bits (208), Expect = 9e-17, Method: Composition-based stats. Identities = 74/464 (15%), Positives = 132/464 (28%), Gaps = 99/464 (21%) Query: 63 SYGQQPYEFFESCRQKYGDVFSFM----LLGKIMTVYLGPKGHEFVFNAKLSDVSAEDAY 118 P FE QK G + + + G+ + G + A S+ Sbjct: 9 RLRLDPVPEFEEL-QKAGPLHEYDTEPGMDGRKQWLVTGHDEVRAIL-ADHERFSSMRPV 66 Query: 119 KHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKL 178 G++ ++ A + +R P+I E + ES Sbjct: 67 DDEADRALLPGILQAYDPPDHTRLRRTVAPAYSARRMERLRPRIEEIVEECLDDFESVGA 126 Query: 179 KEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNL 238 V V I + A L + R +++ + + P L Sbjct: 127 P-----VDFVRHAAWPIPAYIACEFL---GVPRDDQAELSRMIRESRESRLPRQRTLSGL 178 Query: 239 PLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIA 298 + +Y +R RD D ++ + G +++D+E+A Sbjct: 179 GIVNYTKR---------------------LTSGKRRDPGDGMIGVIVREHGAEISDEELA 217 Query: 299 NLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQK 358 L G L+ A+ A +L L P ++ + K Sbjct: 218 GLAEGNLIMAAEQMAAQLAVAVLLLVTHPDQMALLRE----------------------K 255 Query: 359 LPSVNNTIKETLRMHMPLHS-IFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFD 417 +++ +E LR + + R +R+ + + G + S + + Sbjct: 256 PELIDSATEEVLRHASIVEAPAPRVALADVRMAGRD--IHAGDVLTCSMLATNRAP---- 309 Query: 418 NPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAY 477 + FD TR + ++ FG G H CIG A Sbjct: 310 -GDRFDITR-----------------------------EKATHMAFGHGIHHCIGAPLAR 339 Query: 478 VQLGTILTTFVYNLRWTIDGYKVPDPDYSSMVVLPTEPAEIIWE 521 +QL L V VP+ D P PA E Sbjct: 340 LQLRVALPAVVGRFPSL--RLAVPEEDLRF---KPGRPAPFAVE 378 >2QBO-A nrPDB Length = 421 Score = 84.5 bits (207), Expect = 1e-16, Method: Composition-based stats. Identities = 54/387 (13%), Positives = 123/387 (31%), Gaps = 81/387 (20%) Query: 158 YVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEI----------------TIFTAS 201 ++P+ E ++ T + + +AN + P + ++ Sbjct: 88 FIPREAGEAYDFIPTSMDPPEQRQFRALANQVVGMPVVDKLENRIQELACSLIESLRPQG 147 Query: 202 RSLFGDEMRRIFDRSFAQLYSDLDKGFTP-INFVFPNLPLP-HYWRRDAAQKKISATYMK 259 + F ++ F L + L + P + ++ + P A++ + + Sbjct: 148 QCNFTEDYAEPFPIRIFMLLAGLPEEDIPHLKYLTDQMTRPDGSMTFAEAKEALYDYLIP 207 Query: 260 EIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWF 319 I+ RR+ P D I ++ + +G +T E + +L+ G T + ++ Sbjct: 208 IIEQRRQ----KPGTDAIS--IVANGQVNGRPITSDEAKRMCGLLLVVGLDTVVNFLSFS 261 Query: 320 LLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSI 379 + L + P + + + + +E LR L + Sbjct: 262 MEFLAKSPEHRQELIERPERI----------------------PAACEELLRRFS-LVAD 298 Query: 380 FRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSF 439 R +T+ + KG +L+ + ER P D +R Sbjct: 299 GRILTSDYEFH--GVQLKKGDQILLPQMLSGLDERENACPMHVDFSR------------- 343 Query: 440 NSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL-RWTIDGY 498 + FG G H C+G+ A ++ L ++ + ++I Sbjct: 344 ----------------QKVSHTTFGHGSHLCLGQHLARREIIVTLKEWLTRIPDFSIAPG 387 Query: 499 KVPDPDYSSMVVLPTEPAEIIWEKRET 525 + S +V + ++W+ T Sbjct: 388 --AQIQHKSGIVSGVQALPLVWDPATT 412 >5M0P-A nrPDB Length = 428 Score = 83.8 bits (205), Expect = 2e-16, Method: Composition-based stats. Identities = 65/451 (14%), Positives = 135/451 (29%), Gaps = 73/451 (16%) Query: 58 FGSAASYGQQPYEFFESCRQKYG-DVFSFM-LLGKIMTVYLGPKGHEFVFNAKLSDVSAE 115 + +Q Y + + R + VF L GK V G +G E +N +DV Sbjct: 16 LDNTLKVLKQGYLYTTNQRNRLNTSVFQTKALGGKPFVVVTGKEGAEMFYN---NDVVQR 72 Query: 116 DAY--KHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTD 173 + K + + GKG I+ + +++K +T + YV E+ Sbjct: 73 EGMLPKRIVNTLAGKGAIHTVDGKKHVDRKALFMSLMTEGNL-NYV----RELTRTLWHA 127 Query: 174 ESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINF 233 + +++ N+ + + +R G + A + F + Sbjct: 128 NTQRMESMDE--VNIYRESIVLLTKVGTRWA-GVQAPPEDIERIATDMDIMIDSFRALGG 184 Query: 234 VFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMT 293 F Y A++++ ++I R +G+I P H G M Sbjct: 185 AF-----KGYKASKEARRRVEDWLEEQIIETR-KGNIHPPEGTALYEFAHWEDYLGNPMD 238 Query: 294 DQ----EIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLN 349 + ++ N ++ ++ L + E P ++ I E Sbjct: 239 SRTCAIDLMNTFRPLIA-----INRFVSFGLHAMNENPITREKIKSEPD----------- 282 Query: 350 DLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYA 409 +E R + + + K + +P G + + Sbjct: 283 -----------YAYKFAQEVRRYYPFVPFLPGKAKVDIDF--QGVTIPAGVGLALDVYGT 329 Query: 410 HTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHR 469 E +D+P +F P R++T + + HR Sbjct: 330 THDESLWDDPNEFRPERFETWDGSPFDLIPQGGGDYWTN-------------------HR 370 Query: 470 CIGEQFAYVQLGTILTTFVYNLRWTIDGYKV 500 C GE + + + F + + + + Sbjct: 371 CAGEWITVIIMEETMKYFAEKITYDVPEQDL 401 >3DBM-A nrPDB Length = 473 Score = 82.2 bits (201), Expect = 5e-16, Method: Composition-based stats. Identities = 81/457 (17%), Positives = 154/457 (33%), Gaps = 53/457 (11%) Query: 65 GQQPYEFFESCRQKYGDVFSFML-------LGKIMTVYLGPKGHEFVFN-AKLSDVSAED 116 G+ Y F ++ VF + + V L K +F+ +K+ Sbjct: 35 GRDEY-FRSRMQKYQSTVFRANMPPGPFVSSNPKVIVLLDAKSFPILFDVSKVEKKDLFT 93 Query: 117 AYKHLTTPVFG--KGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDE 174 +T + G + + Y P+ Q K F + +S R +P+ F E Sbjct: 94 GTYMPSTKLTGGYRVLSYLDPSEPRHAQLKNLLFFMLKNSSNRVIPQFETTYTELFEGLE 153 Query: 175 SFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSF---AQLYSDLDKGFTPI 231 + K +V + + A + +E + + + +L Sbjct: 154 AELAKNGKAAFNDVGEQAAFRFLGRAYFNSNPEETKLGTSAPTLISSWVLFNLAPTLDLG 213 Query: 232 NFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVK 291 F PL H +R A I +TY K + ++ K GV Sbjct: 214 LPWFLQEPLLHTFRLPAFL--IKSTYNKLYDYFQSVATP----------VMEQAEKLGVP 261 Query: 292 MTDQEIANLLIGI---LMGGQHTS-ASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGD 347 D+ + N+L + GG +T W L GE H Q + +E+ +K G Sbjct: 262 -KDEAVHNILFAVCFNTFGGVKILFPNTLKWIGLA-GENLHTQ--LAEEIRGAIKSYG-- 315 Query: 348 LNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIP--ETNYIVPKGHYVLVS 405 ++T E ++++P + + E+LR+ P+ + K + I + + V KG + Sbjct: 316 DGNVTLEAIEQMPLTKSVVYESLRIEPPVPPQYGKAKSNFTIESHDATFEVKKGEMLFGY 375 Query: 406 PGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGG 465 +A + FD PE++ P R+ + S+ +K Sbjct: 376 QPFATKDPKVFDRPEEYVPDRFVGDGEALLKYVWWSNGPETESPTVENK----------- 424 Query: 466 GRHRCIGEQFAYVQLGTILTTFVYNLR-WTIDGYKVP 501 +C G+ F + + + I+ + P Sbjct: 425 ---QCAGKDFVVLITRLFVIELFRRYDSFEIELGESP 458 >2RCM-A nrPDB Length = 495 Score = 80.7 bits (197), Expect = 1e-15, Method: Composition-based stats. Identities = 70/471 (14%), Positives = 147/471 (31%), Gaps = 63/471 (13%) Query: 50 LVFYWIPWFGSAAS-----YGQQPYEFFESCRQKYG--------DVFSFMLLGKIMTVYL 96 Y +P G Y Q EFF+S +KY +F+ + L Sbjct: 31 PGNYGLPIVGPIKDRWDYFYDQGAEEFFKSRIRKYNSTVYRVNMPPGAFIAENPQVVALL 90 Query: 97 GPKGHEFVFNA-KLSDVSAEDAYKHLTTPVFG--KGVIYDCPNSRLMEQKKFAKFALTTD 153 K +F+ K+ +T + G + + Y P+ E+ K F L Sbjct: 91 DGKSFPVLFDVDKVEKKDLLTGTYMPSTELTGGYRILSYLDPSEPKHEKLKNLLFFLLKS 150 Query: 154 SFKRYVPKIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIF 213 S R P+ + F + E G A+ + +R+ +G Sbjct: 151 SRNRIFPEFQATYSELFDSLEKEL---SLKGKADFGGSSDGTAFNFLARAFYGTNPADTK 207 Query: 214 DRSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPN 273 ++ A G +F PL ++ + T+ + + Sbjct: 208 LKADA-------PGLITKWVLFNLHPLLSIGLPRVIEEPLIHTFS------LPPALVKSD 254 Query: 274 RDLIDSLLIHSTYK-----DGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEK-- 326 + + S + D + ++ +E + +L + ++ ++ Sbjct: 255 YQRLYEFFLESAGEILVEADKLGISREEATHN---LLFATCFNTWGGMKILFPNMVKRIG 311 Query: 327 ---PHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKV 383 + + + +E+ ++K GG +LT ++K+ + + E LR P+ + + + Sbjct: 312 RAGHQVHNRLAEEIRSVIKSNGG---ELTMGAIEKMELTKSVVYECLRFEPPVTAQYGRA 368 Query: 384 TNPLRIP--ETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNS 441 L I + + V G + A + FD ++F P R+ + Sbjct: 369 KKDLVIESHDAAFKVKAGEMLYGYQPLATRDPKIFDRADEFVPERFVGEEGEKLLRHVLW 428 Query: 442 SDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLR 492 S+ + V G +C G+ F + + Sbjct: 429 SNGPETETPTV-------------GNKQCAGKDFVVLVARLFVIEIFRRYD 466 >5D3U-A nrPDB Length = 427 Score = 79.1 bits (193), Expect = 5e-15, Method: Composition-based stats. Identities = 48/369 (13%), Positives = 100/369 (27%), Gaps = 75/369 (20%) Query: 126 FGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTHGV 185 + K V+ ++ + T + + Y +++ + + + Sbjct: 103 WTKNVVMYTDPPLHDALRRSVRAGFTRAAHQHYDQVLQKVAHDLVASIPAG--------- 153 Query: 186 ANVMKTQPEITIFTASRSLFGDEMRRIFDRSFAQLYSDLDKGFTPINFVFPNLPLPHYWR 245 A + P + RS +F DL +N + P Sbjct: 154 ATEIDAVPALAAELPVRSAV---------HAFGVPEEDLGFLIPRVNTIMTYFSGPKDQP 204 Query: 246 RDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLL--IHSTYKDGVKMTDQEIANLLIG 303 Q+ I E + L D+++ + + + T ++ + L Sbjct: 205 --VTQEIILEKLTDLHTYASELLQGMRGKVLPDTVIARLAAAQDGLTETTPEQTVHQLAL 262 Query: 304 ILMGGQH-TSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSV 362 + + T+ + + L P + + + Sbjct: 263 VFIALFAPTTPGSLSSGTLAFARNPRQVERFLADQACV---------------------- 300 Query: 363 NNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDF 422 +NT E LR + +R + + + G + + G A+ F+ P DF Sbjct: 301 DNTANEVLRYNASNQFTWRVAAKDVEM--GGVRIEAGQTLALFLGSANRDANMFERPNDF 358 Query: 423 DPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGT 482 D R S+ +L FG G H C+ Q +QL Sbjct: 359 DLDR----------------------------PNSARHLSFGQGVHACLAAQLISLQLKW 390 Query: 483 ILTTFVYNL 491 + Sbjct: 391 FYVALLNRF 399 >4C9K-A nrPDB Length = 421 Score = 78.7 bits (192), Expect = 6e-15, Method: Composition-based stats. Identities = 68/376 (18%), Positives = 117/376 (31%), Gaps = 81/376 (21%) Query: 164 EEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASR--SLFGDEMRRIFD------- 214 E D+ L E + EI A R FG E +F Sbjct: 109 EHTPYRKAIDKGLNLAEIRKLEDQIRTIAVEIIEGFADRGHCEFGSEFSTVFPVRVFLAL 168 Query: 215 -----RSFAQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGD 269 +L ++ P N P +AA K I +RR Sbjct: 169 AGLPVEDATKLGLLANEMTRPSG----NTPEEQGRSLEAANKGFFEYVAPIIAARR---- 220 Query: 270 IDPNRDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHL 329 DLI +L DG M D L+ +L+GG T + + +++L P Sbjct: 221 GGSGTDLITRILN--VEIDGKPMPDDRALGLVSLLLLGGLDTVVNFLGFMMIYLSRHPET 278 Query: 330 QDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRI 389 + +E ++ + ++E R + S R V + + Sbjct: 279 VAEMRREPLK----------------------LQRGVEELFRRFA-VVSDARYVVSDMEF 315 Query: 390 PETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGF 449 T ++ +G +L+ +R+ D+P D +R D Sbjct: 316 HGT--MLKEGDLILLPTALHGLDDRHHDDPMTVDLSRRDVT------------------- 354 Query: 450 GKVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL-RWTIDGYKVPDPDYSSM 508 + F G HRC G A +++ +L ++ + + + VP Y S Sbjct: 355 ----------HSTFAQGPHRCAGMHLARLEVTVMLQEWLARIPEFRLKDRAVPI--YHSG 402 Query: 509 VVLPTEPAEIIWEKRE 524 +V E + WE + Sbjct: 403 IVAAVENIPLEWEPQR 418 >2IJ7-A nrPDB Length = 396 Score = 78.0 bits (190), Expect = 9e-15, Method: Composition-based stats. Identities = 32/203 (15%), Positives = 69/203 (33%), Gaps = 53/203 (26%) Query: 290 VKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLN 349 ++D+ A + + G ++ S L+ L ++P L++++++ Sbjct: 216 SHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHE-------------- 261 Query: 350 DLTYEDLQKLPSVNNTIKETLRMHMP-LHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGY 408 K + ++E LR+++ + R T +++ + +V KG VLV Sbjct: 262 --------KPELIPAGVEELLRINLSFADGLPRLATADIQV--GDVLVRKGELVLVLLEG 311 Query: 409 AHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRH 468 A+ +F NP + R + +L FG G+H Sbjct: 312 ANFDPEHFPNPGSIELDR----------------------------PNPTSHLAFGRGQH 343 Query: 469 RCIGEQFAYVQLGTILTTFVYNL 491 C G + + + Sbjct: 344 FCPGSALGRRHAQIGIEALLKKM 366 >2NZA-A nrPDB Length = 413 Score = 76.0 bits (185), Expect = 4e-14, Method: Composition-based stats. Identities = 43/267 (16%), Positives = 79/267 (29%), Gaps = 63/267 (23%) Query: 240 LPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDLIDSLLIHSTYKDGVKMTDQEIAN 299 + +AA++ Y ++ R R + + S+L + + ++ + E Sbjct: 182 ISTSGGAEAAERAKRGLYGWITETVRARAGSEGGD--VYSMLGAAVGRG--EVGETEAVG 237 Query: 300 LLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKL 359 L + +GG L L + L + + G Sbjct: 238 LAGPLQIGG-EAVTHNVGQMLYLLLTRRELMARMRE-----RPGARGT------------ 279 Query: 360 PSVNNTIKETLRM--HMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFD 417 + E LR H + R + + T + G V VS A+ F Sbjct: 280 -----ALDELLRWISHRTSVGLARIALEDVEVHGTR--IAAGEPVYVSYLAANRDPDVFP 332 Query: 418 NPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRCIGEQFAY 477 +P+ D R +P+L +G G H C G A Sbjct: 333 DPDRIDLDR-----------------------------DPNPHLAYGNGHHFCTGAVLAR 363 Query: 478 VQLGTILTTFVYN---LRWTIDGYKVP 501 +Q ++ T + LR + +V Sbjct: 364 MQTELLVDTLLERLPGLRLAVPAEQVA 390 >3NV6-A nrPDB Length = 452 Score = 74.1 bits (180), Expect = 1e-13, Method: Composition-based stats. Identities = 61/368 (16%), Positives = 119/368 (32%), Gaps = 73/368 (19%) Query: 164 EEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASR--SLFGDEMRRIFDRSFAQLY 221 E D+ L + V + + A+R F E +F Sbjct: 143 EHTPYRKALDKGLNLAKIRKVEDKVREVASSLIDSFAARGECDFAAEYAELFPVHVFMAL 202 Query: 222 SDLDKGFTPINFVFP--------NLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPN 273 +DL P+ + N P +A A I++R + + Sbjct: 203 ADLPLEDIPVLSEYARQMTRPEGNTPEEMATDLEAGNNGFYAYVDPIIRAR-----VGGD 257 Query: 274 RDLIDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVI 333 D + +L+++S +G ++ + L+ +L+GG T + ++F++HL P L + Sbjct: 258 GDDLITLMVNSEI-NGERIAHDKAQGLISLLLLGGLDTVVNFLSFFMIHLARHPELVAEL 316 Query: 334 YQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETN 393 + ++L++ +E R P+ S R V Sbjct: 317 RSDPLKLMRGA----------------------EEMFRRF-PVVSEARMVAKDQEY--KG 351 Query: 394 YIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVS 453 + +G +L+ + P D +R Sbjct: 352 VFLKRGDMILLPTALHGLDDAANPEPWKLDFSR--------------------------- 384 Query: 454 KGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNL-RWTIDGYKVPDPDYSSMVVLP 512 S + FGGG HRC G A +++ L ++ + ++ + P Y S +V Sbjct: 385 --RSISHSTFGGGPHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEGETPI--YHSGIVAA 440 Query: 513 TEPAEIIW 520 E ++W Sbjct: 441 VENVPLVW 448 >2YJN-B nrPDB Length = 381 Score = 51.0 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 29/128 (22%), Positives = 48/128 (37%), Gaps = 24/128 (18%) Query: 305 LMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNN 364 L G +A+T +L + +P L + I +D + Sbjct: 220 LFAGAEMTANTVVDAVLAVSAEPGLAERI-------------------ADDPA---AAQR 257 Query: 365 TIKETLRMHMPLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDP 424 T+ E LR+H LH R T +R+ +++ +G V+V A+ F P+ D Sbjct: 258 TVAEVLRLHPALHLERRTATAEVRL--GEHVIGEGEEVVVVVAAANRDPEVFAEPDRLDV 315 Query: 425 TRWDTAAA 432 R D A Sbjct: 316 DRPDADRA 323 >5EUV-A nrPDB Length = 731 Score = 32.1 bits (71), Expect = 0.57, Method: Composition-based stats. Identities = 16/96 (16%), Positives = 24/96 (25%), Gaps = 6/96 (6%) Query: 375 PLHSIFRKVTNPLRIPETNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKA 434 PL + R P + K LV+ H +PE Sbjct: 418 PLINRPRTALRPTEEVTG---IKKPVPYLVTEYNGHMFPTKAQDPELRQMEHV---IRHL 471 Query: 435 NSVSFNSSDEVDYGFGKVSKGVSSPYLPFGGGRHRC 470 ++ D G + + FG G C Sbjct: 472 EVLNAAHGDPAISGCIGWCMFDYNTHKDFGAGDRIC 507 >5J04-A nrPDB Length = 425 Score = 31.8 bits (70), Expect = 0.81, Method: Composition-based stats. Identities = 18/105 (17%), Positives = 40/105 (38%), Gaps = 1/105 (0%) Query: 288 DGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQEVVELLKEKGGD 347 DG AN ++ + + H +A++ L P L +V+ ++ ++ Sbjct: 98 DGTPNKKNLGANAILAVSLATAHAAATSLNLPLYRYLGGP-LANVLPVPMMNVINGGAHA 156 Query: 348 LNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPET 392 N++ +++ +P + KE LR + KV + Sbjct: 157 DNNVDFQEFMIMPVGAPSFKEALRWGAEVFHALAKVLKDKGLATG 201 >2CLY-A nrPDB Length = 214 Score = 31.8 bits (70), Expect = 0.85, Method: Composition-based stats. Identities = 31/161 (19%), Positives = 47/161 (29%), Gaps = 8/161 (4%) Query: 54 WIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAKLSDVS 113 +P G +G P EFF+ K G V +LG + +YL K + S Sbjct: 4 PLPEHGGKVRFGLIPEEFFQFLYPKTG-VTGPYVLGTGLILYLLSKEIYVI---TPETFS 59 Query: 114 AEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKIREEILNYFVTD 173 A L V G +L EQK + S K+ I E + Sbjct: 60 AISTIGFLVYIVKKYGASVGEFADKLNEQKIAQLEEVKQASIKQIQDAIDMEKSQQALVQ 119 Query: 174 ESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFD 214 + L + + E++ D Sbjct: 120 KRHYLFDVQRNNI----AMALEVTYRERLHRVYREVKNRLD 156 >2NYG-A nrPDB Length = 273 Score = 31.4 bits (69), Expect = 0.95, Method: Composition-based stats. Identities = 15/80 (18%), Positives = 26/80 (32%), Gaps = 8/80 (10%) Query: 398 KGHYVLVSPGYAHTSERYFDNP----EDFDPTRWDTAAAKANSVSFNSSD---EVDYGFG 450 +G V+ S + + + NP E +D R A +N + Sbjct: 63 EGTIVMPSQSVELSDPKEWGNPPVPEEWWDIIRESMPAYNSNYTPTTRGMGQIVELFRSY 122 Query: 451 KVSKGVSSPYLPF-GGGRHR 469 K + P F G+H+ Sbjct: 123 PEVKRSNHPNYSFVAWGKHK 142 >2ISB-A nrPDB Length = 192 Score = 31.4 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 13/62 (20%), Positives = 24/62 (38%), Gaps = 2/62 (3%) Query: 126 FGKGVIYDCPNSRLM--EQKKFAKFALTTDSFKRYVPKIREEILNYFVTDESFKLKEKTH 183 F KGV+Y C E + + T+ + PKI E++ + + +E Sbjct: 68 FDKGVVYHCGPLVKKNDEWRVVSAGPTTSARMNPFTPKILEKVECMGIIGKGGMSEEVVE 127 Query: 184 GV 185 + Sbjct: 128 AM 129 >3UR7-A nrPDB Length = 323 Score = 30.2 bits (66), Expect = 2.6, Method: Composition-based stats. Identities = 10/54 (18%), Positives = 20/54 (37%) Query: 39 YLYSLRKDRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIM 92 + L + PL+ P+FG + P + +Q+ D L ++ Sbjct: 162 IIGFLARHNLPLLANIYPYFGHIDNTNAVPLSYALFNQQRRNDTGYQNLFDALV 215 >3IJW-A nrPDB Length = 268 Score = 29.8 bits (65), Expect = 3.0, Method: Composition-based stats. Identities = 14/79 (17%), Positives = 29/79 (36%), Gaps = 9/79 (11%) Query: 398 KGHYVLVSPGYAHTSERYFDNP----EDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVS 453 +G ++ + + +++ P E + R + A + + + +V F Sbjct: 65 EGTIIMPTQSSDLSDPKHWSRPPVPEEWWQIIRDNVPAFEPHITPTRAMGKVVECFRTYP 124 Query: 454 KGVSSPYLPFG----GGRH 468 V S + P G GRH Sbjct: 125 NVVRSNH-PLGSFAAWGRH 142 >2D6F-C nrPDB Length = 619 Score = 28.7 bits (62), Expect = 6.5, Method: Composition-based stats. Identities = 12/78 (15%), Positives = 30/78 (38%), Gaps = 2/78 (2%) Query: 232 NFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDID--PNRDLIDSLLIHSTYKDG 289 + ++ +P + D + I + ++ER D + DL L+ + + Sbjct: 418 SRMYLETDIPLFRIEDDLLEGIRRNLPELPSEKKERIMRDYGLSEDLASQLVKRNLVDEF 477 Query: 290 VKMTDQEIANLLIGILMG 307 +T+ + +I L+ Sbjct: 478 EALTEFRVDTTVIASLLA 495 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.118 0.302 Lambda K H 0.267 0.0366 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,325,709 Number of Sequences: 36641 Number of extensions: 704302 Number of successful extensions: 3035 Number of sequences better than 10.0: 176 Number of HSP's better than 10.0 without gapping: 232 Number of HSP's successfully gapped in prelim test: 64 Number of HSP's that attempted gapping in prelim test: 2058 Number of HSP's gapped (non-prelim): 399 length of query: 528 length of database: 10,336,785 effective HSP length: 102 effective length of query: 426 effective length of database: 6,599,403 effective search space: 2811345678 effective search space used: 2811345678 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.5 bits) S2: 61 (28.3 bits)