BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P10378 (536 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3RG2-A nrPDB 1107 0.0 3O84-A nrPDB 600 e-172 1MDF-A nrPDB 490 e-139 5BUS-A nrPDB 150 2e-36 4FUQ-A nrPDB 146 2e-35 5IE2-A nrPDB 134 9e-32 2V7B-A nrPDB 127 1e-29 5BSW-A nrPDB 125 7e-29 3IPL-A nrPDB 124 1e-28 1V25-A nrPDB 120 1e-27 3A9U-A nrPDB 120 2e-27 3IVR-A nrPDB 118 8e-27 4EAT-A nrPDB 117 1e-26 3TSY-A nrPDB 117 2e-26 4WV3-A nrPDB 114 1e-25 3R44-A nrPDB 114 1e-25 4M46-A nrPDB 105 5e-23 3DLP-X nrPDB 102 3e-22 3GPC-A nrPDB 101 7e-22 5DWV-A nrPDB 101 8e-22 4LGC-A nrPDB 100 2e-21 5JRH-A nrPDB 95 6e-20 4R0M-B nrPDB 94 2e-19 2D1S-A nrPDB 92 4e-19 3L8C-A nrPDB 92 6e-19 3ETC-A nrPDB 88 1e-17 4GR5-A nrPDB 85 7e-17 1RY2-A nrPDB 84 2e-16 5ES6-A nrPDB 82 7e-16 5ES8-A nrPDB 81 1e-15 6NJ0-A nrPDB 78 1e-14 3FCE-A nrPDB 76 5e-14 3E7W-A nrPDB 74 1e-13 5WMM-A nrPDB 74 2e-13 5U29-A nrPDB 71 9e-13 3PBK-A nrPDB 59 5e-09 5JNF-C nrPDB 50 2e-06 3LNV-A nrPDB 46 4e-05 4WD1-A nrPDB 43 3e-04 4GR4-A nrPDB 40 0.002 4RVO-A nrPDB 36 0.033 4IZO-A nrPDB 35 0.073 4E4T-A nrPDB 33 0.42 2Y4N-A nrPDB 32 0.76 5EP0-A nrPDB 32 1.0 2ATV-A nrPDB 31 1.2 1UFR-A nrPDB 30 1.8 1EWN-A nrPDB 29 5.2 6HIV-BC nrPDB 29 5.3 5D6N-A nrPDB 29 6.4 5EY8-A nrPDB 29 6.5 4WKO-A nrPDB 28 8.2 >3RG2-A nrPDB Length = 617 Score = 1107 bits (2862), Expect = 0.0, Method: Compositional matrix adjust. Identities = 536/536 (100%), Positives = 536/536 (100%) Query: 1 MSIPFTRWPEEFARRYREKGYWQDLPLTDILTRHAASDSIAVIDGERQLSYRELNQAADN 60 MSIPFTRWPEEFARRYREKGYWQDLPLTDILTRHAASDSIAVIDGERQLSYRELNQAADN Sbjct: 3 MSIPFTRWPEEFARRYREKGYWQDLPLTDILTRHAASDSIAVIDGERQLSYRELNQAADN 62 Query: 61 LACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIE 120 LACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIE Sbjct: 63 LACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIE 122 Query: 121 PALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSP 180 PALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSP Sbjct: 123 PALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSP 182 Query: 181 ADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSS 240 ADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSS Sbjct: 183 ADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSS 242 Query: 241 PGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLA 300 PGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLA Sbjct: 243 PGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLA 302 Query: 301 SLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMC 360 SLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMC Sbjct: 303 SLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMC 362 Query: 361 PDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISID 420 PDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISID Sbjct: 363 PDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISID 422 Query: 421 PEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVV 480 PEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVV Sbjct: 423 PEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVV 482 Query: 481 KEPLRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLASRASA 536 KEPLRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLASRASA Sbjct: 483 KEPLRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLASRASA 538 >3O84-A nrPDB Length = 544 Score = 600 bits (1547), Expect = e-172, Method: Compositional matrix adjust. Identities = 301/539 (55%), Positives = 389/539 (72%), Gaps = 7/539 (1%) Query: 3 IPFTRWPEEFARRYREKGYWQDLPLTDILTRHAASD--SIAVIDGERQLSYRELNQAADN 60 I F RW E A+ YR KGYW D PLT ILT S S+A+I GERQLSY EL++ + N Sbjct: 8 IEFVRWSPERAQHYRNKGYWIDQPLTRILTVGVQSHPHSLAIICGERQLSYIELDRLSTN 67 Query: 61 LACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIE 120 LA L +G+ G+TALVQL NVAE YI FFALLK GV + AL+SH++ ELNA+ QI+ Sbjct: 68 LATRLAEKGLGKGDTALVQLPNVAEFYIVFFALLKAGVVVLNALYSHRQYELNAFIKQIQ 127 Query: 121 PALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLN-DSGEHNLQDAINHPAEDFTA-TP 178 P LLI RQH +FS + F+++ + S ++ +LN + + L D I PAE F + Sbjct: 128 PKLLIGSRQHEVFSNNQFIDSLHDVNLSPEIILMLNHQATDFGLLDWIETPAETFVDFSS 187 Query: 179 SPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAM 238 +PADEVA+FQLSGG+TGTPKLIPRTHNDY YSVR S EIC TR LCA+PA HN+ + Sbjct: 188 TPADEVAFFQLSGGSTGTPKLIPRTHNDYDYSVRASAEICGLNSNTRLLCALPAPHNFML 247 Query: 239 SSPGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQ 298 SSPG+LGV AGG VV+A +P CF +I++HQVN+ +LVP AV +WL+ + + Q Sbjct: 248 SSPGALGVLHAGGCVVMAPNPEPLNCFSIIQRHQVNMASLVPSAVIMWLEK--AAQYKDQ 305 Query: 299 LASLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYP 358 + SLKLLQVGGA +LA ++P + C+LQQVFGMAEGLVNYTRLDDS E+I TQG P Sbjct: 306 IQSLKLLQVGGASFPESLARQVPEVLNCKLQQVFGMAEGLVNYTRLDDSDEQIFTTQGRP 365 Query: 359 MCPDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLIS 418 + DDE+ + D + +P+GE+G L TRGPYTF GYY+SP+HN+ FD + +Y SGDL+ Sbjct: 366 ISSDDEIKIVDEQYREVPEGEIGMLATRGPYTFCGYYQSPEHNSQVFDEDNYYYSGDLVQ 425 Query: 419 IDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYL 478 P+G + V GR KDQINRGGEKIA+EEIE L+L HP V++AALV++ DE GEKSCA++ Sbjct: 426 RTPDGNLRVVGRIKDQINRGGEKIASEEIEKLILLHPEVMHAALVAIVDEQFGEKSCAFI 485 Query: 479 VVKEP-LRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLASRASA 536 V + P L+AV +RR L E GIA++KLPD+++ ++SLPLTAVGKVDKKQLR L + ++ Sbjct: 486 VSRNPELKAVVLRRHLMELGIAQYKLPDQIKLIESLPLTAVGKVDKKQLRSILNTSTTS 544 >1MDF-A nrPDB Length = 539 Score = 490 bits (1262), Expect = e-139, Method: Compositional matrix adjust. Identities = 259/537 (48%), Positives = 345/537 (64%), Gaps = 17/537 (3%) Query: 5 FTRWPEEFARRYREKGYWQDLPLTDILTRHAAS--DSIAVIDGERQLSYRELNQAADNLA 62 FT WP+E A YR+ G W D+L AA D IA+ G SYREL+ AD LA Sbjct: 5 FTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAITCGNTHWSYRELDTRADRLA 64 Query: 63 CSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPA 122 ++ GI+ + +VQL N+ E + FAL +LG PV AL SH+ SE+ + E A Sbjct: 65 AGFQKLGIQQKDRVVVQLPNIKEFFEVIFALFRLGALPVFALPSHRSSEITYFCEFAEAA 124 Query: 123 LLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSP-- 180 I +SG D+ + S + ++ + +GE ++ + P ED P Sbjct: 125 AYIIPDA---YSGFDYRSLARQVQSKLPTLKNIIVAGE--AEEFL--PLEDLHTEPVKLP 177 Query: 181 ---ADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYA 237 + +VA+ QLSGG+TG KLIPRTH+DY YS++RSVE+C T YL A+P AHNY Sbjct: 178 EVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVCWLDHSTVYLAALPMAHNYP 237 Query: 238 MSSPGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRA 297 +SSPG LGV AGG VVL+ PS FPLIE+ +V +TALVPP +W+ A R Sbjct: 238 LSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTITALVPPLAMVWMDA--ASSRRD 295 Query: 298 QLASLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGY 357 L+SL++LQVGGA+ SA A R+ A GC LQQVFGMAEGLVNYTRLDD E I++TQG Sbjct: 296 DLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAEGLVNYTRLDDPEEIIVNTQGK 355 Query: 358 PMCPDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLI 417 PM P DE V D + GE G L+TRGPYT RGYYK+ +HNA++F +GFY +GD++ Sbjct: 356 PMSPYDESRVWDDHDRDVKPGETGHLLTRGPYTIRGYYKAEEHNAASFTEDGFYRTGDIV 415 Query: 418 SIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAY 477 + +GYI V+GR KDQINRGGEK+AAEE+EN LL HPAV AA+VSM D+ +GE+SC + Sbjct: 416 RLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLLAHPAVHDAAMVSMPDQFLGERSCVF 475 Query: 478 LVVK-EPLRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLASR 533 ++ + E +A +++ FLRE+G+A +K+PDRVE V+S P T VGKV KK LR+ ++ + Sbjct: 476 IIPRDEAPKAAELKAFLRERGLAAYKIPDRVEFVESFPQTGVGKVSKKALREAISEK 532 >5BUS-A nrPDB Length = 494 Score = 150 bits (378), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 140/494 (28%), Positives = 230/494 (46%), Gaps = 37/494 (7%) Query: 38 DSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLG 97 + IA+I ++ +++ EL A+ +A L ++ G+TA + L N AE+ A LG Sbjct: 20 ERIALIYEDQTVTFAELFAASKRMAEQLAAHSVRKGDTAAILLQNRAEMVYAVHACFLLG 79 Query: 98 VAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEH--SSIRVVQLL 155 V VL LN S E + D D EH +I V +L+ Sbjct: 80 VKAVL---------LNTKLSTHERLFQLEDSGSGFLLTDSSFEKKEYEHIVQTIDVDELM 130 Query: 156 NDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSV 215 ++ E +A D A + GTTG PK + +T ++Y+S S Sbjct: 131 KEAAEEIEIEAYMQ-----------MDATATLMYTSGTTGKPKGVQQTFGNHYFSAVSSA 179 Query: 216 EICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNV 275 T+Q R+L A+P H +S+ ++ G TVVL S + I +H+V + Sbjct: 180 LNLGITEQDRWLIALPLFHISGLSALFKSVIY--GMTVVLHQRFSVSDVLHSINRHEVTM 237 Query: 276 TALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMA 335 + AV L +L+E +R S++ + +GG L E G + Q +GM Sbjct: 238 IS----AVQTMLASLLEETNRCP-ESIRCILLGGGPAPLPLLEEC-REKGFPVFQSYGMT 291 Query: 336 EGLVNYTRL--DDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRG 393 E L + S EK+ + G P+ E+ + + +G E G +M +GP + Sbjct: 292 ETCSQIVTLSPEFSMEKL-GSAGKPLF-SCEIKI-ERDGQVCEPYEHGEIMVKGPNVMKS 348 Query: 394 YYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLR 453 Y+ N ++F NG+ +GDL +D EG++ V R D I GGE I E+E++LL Sbjct: 349 YFNRESANEASFQ-NGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGENIYPAEVESVLLS 407 Query: 454 HPAVIYAALVSMEDELMGEKSCAYLVVKEPLRAVQVRRFLREQGIAEFKLPDRVECVDSL 513 HPAV A + ED+ G+ AYLV+ +P+ A ++ + +E+ +A++K+P + +D L Sbjct: 408 HPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKER-LAKYKIPAKFFVLDRL 466 Query: 514 PLTAVGKVDKKQLR 527 P A K+ + QL+ Sbjct: 467 PRNASNKLLRNQLK 480 >4FUQ-A nrPDB Length = 503 Score = 146 bits (369), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 129/485 (26%), Positives = 221/485 (45%), Gaps = 20/485 (4%) Query: 48 QLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSH 107 ++SY EL A +A L +G++ G+ Q E + + A ++ G + ++ Sbjct: 28 KISYAELVARAGRVANVLVARGLQVGDRVAAQTEKSVEALVLYLATVRAGGVYLPLNTAY 87 Query: 108 QRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQDAI 167 EL+ + + EP +++ D S D + + + V+ L G +L DA Sbjct: 88 TLHELDYFITDAEPKIVVCDP-----SKRDGIAAIAAKVGA--TVETLGPDGRGSLTDAA 140 Query: 168 NHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYL 227 +E F AD++A + GTTG K +H++ + V+ +FT + Sbjct: 141 AGASEAFATIDRGADDLAAILYTSGTTGRSKGAMLSHDNLASNSLTLVDYWRFTPDDVLI 200 Query: 228 CAIPAAHNYAMSSPGSLGVFLAGGTVVLAA-DPSATLCFPLIEKHQVNVTALVPPAVSLW 286 A+P H + + ++ +F G + L DP L + V VP + Sbjct: 201 HALPIYHTHGLFVASNVTLFARGSMIFLPKFDPDKILDL----MARATVLMGVPTFYTRL 256 Query: 287 LQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDD 346 LQ+ ++ ++L G A L A A+ G + + +GM E +N + D Sbjct: 257 LQS--PRLTKETTGHMRLFISGSAPLLADTHREWSAKTGHAVLERYGMTETNMNTSNPYD 314 Query: 347 SAEKIIHTQGYPMCPDDEVWVADAE-GNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAF 405 +++ G P P V D E G LP+G++G + +GP F+GY++ P+ S F Sbjct: 315 -GDRVPGAVG-PALPGVSARVTDPETGKELPRGDIGMIEVKGPNVFKGYWRMPEKTKSEF 372 Query: 406 DANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSM 465 +GF+ +GDL ID GY+ + GR KD + GG + +EIE+ + P V+ +A++ + Sbjct: 373 RDDGFFITGDLGKIDERGYVHILGRGKDLVITGGFNVYPKEIESEIDAMPGVVESAVIGV 432 Query: 466 EDELMGEKSCAYLVVKE--PLRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDK 523 GE A +V + + QV L Q +A+FK+P +V VD LP +GKV K Sbjct: 433 PHADFGEGVTAVVVRDKGATIDEAQVLHGLDGQ-LAKFKMPKKVIFVDDLPRNTMGKVQK 491 Query: 524 KQLRQ 528 LR+ Sbjct: 492 NVLRE 496 >5IE2-A nrPDB Length = 514 Score = 134 bits (337), Expect = 9e-32, Method: Compositional matrix adjust. Identities = 120/502 (23%), Positives = 222/502 (44%), Gaps = 34/502 (6%) Query: 43 IDGERQLSYRELNQAADNLACSL-RRQGIKPGETALVQLGNVAELYITFFALLKL--GVA 99 + G+ L++ L+ + A L GIKPG+ + N E I F A+++ A Sbjct: 25 VSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFPNTVEFVIMFLAVIRARATAA 84 Query: 100 PVLALFSHQRSELNAYASQIEPALLIADRQ--------HALFSGDDFLNTFVTEHSSIRV 151 P+ A ++ + E Y S + LL+ ++ + T + S + + Sbjct: 85 PLNAAYTAEEFEF--YLSDSDSKLLLTSKEGNAPAQEAASKLKISHVTATLLDAGSDLVL 142 Query: 152 VQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSV 211 +DS + + +NHP D+ A F + GTT PK +P T + SV Sbjct: 143 SVADSDSVVDSATELVNHP-----------DDGALFLHTSGTTSRPKGVPLTQLNLASSV 191 Query: 212 RRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADP-SATLCFPLIEK 270 + + + T+ + +P H + + + + + AA SAT +P ++K Sbjct: 192 KNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVTLPAAGRFSATTFWPDMKK 251 Query: 271 HQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIGCQLQQ 330 + VP + L + L+ ++ A L+ + +R+ G + + Sbjct: 252 YNATWYTAVPTIHQIILDRH-ASHPETEYPKLRFIRSCSASLAPVILSRLEEAFGAPVLE 310 Query: 331 VFGMAEG--LVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMTRGP 388 + M E L++ L + + G P+ E+ + + +G G + RGP Sbjct: 311 AYAMTEATHLMSSNPLPEEGPHKPGSVGKPV--GQEMAILNEKGEIQEPNNKGEVCIRGP 368 Query: 389 YTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIE 448 +GY +P+ N + F+ G++ +GD+ D +GY+ + GR K+ INRGGEKI+ E++ Sbjct: 369 NVTKGYKNNPEANKAGFEF-GWFHTGDIGYFDTDGYLHLVGRIKELINRGGEKISPIEVD 427 Query: 449 NLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKEPLRAVQ--VRRFLREQGIAEFKLPDR 506 +LL HP V + DE GE+ ++ +E + ++ F + + +A FK+P R Sbjct: 428 AVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEEDIKAFCK-KNLAAFKVPKR 486 Query: 507 VECVDSLPLTAVGKVDKKQLRQ 528 V D+LP TA GK+ ++ + Q Sbjct: 487 VFITDNLPKTASGKIQRRIVAQ 508 >2V7B-A nrPDB Length = 529 Score = 127 bits (319), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 127/512 (24%), Positives = 229/512 (44%), Gaps = 48/512 (9%) Query: 41 AVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAP 100 A ID +Y EL + A A +LR G+ P E L+ + + L + F L GV P Sbjct: 41 AYIDDTGSTTYGELEERARRFASALRTLGVHPEERILLVMLDTVALPVAFLGALYAGVVP 100 Query: 101 VLA-----------LFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSI 149 V+A + +H + + I L+ + AL S EH Sbjct: 101 VVANTLLTPADYVYMLTHSHAR-----AVIASGALVQNVTQALESA---------EHDGC 146 Query: 150 RVVQLLNDSGEHNL----QDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHN 205 +++ E L ++ I+ A A + D++A++ S G+TG PK TH Sbjct: 147 QLIVSQPRESEPRLAPLFEELIDAAAPAAKAAATGCDDIAFWLYSSGSTGKPKGTVHTHA 206 Query: 206 DYYYSVRRSVE-ICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLC 264 + Y++ + I + A Y + + + + + +++A P+A Sbjct: 207 NLYWTAELYAKPILGIAENDVVFSAAKLFFAYGLGNGLTFPLSVGATAILMAERPTADAI 266 Query: 265 FPLIEKHQVNVTALVPPAVSLWLQALIEGE--SRAQLASLKLLQVGGARLSATLAARIPA 322 F + +H+ V VP +L+ L+ +RA +A +++ G L + R A Sbjct: 267 FARLVEHRPTVFYGVP---TLYANMLVSPNLPARADVA-IRICTSAGEALPREIGERFTA 322 Query: 323 EIGCQLQQVFGMAEGLVNYTRLDDSAEKIIH-TQGYPMCPDDEVWVADAEGNPLPQGEVG 381 GC++ G E L + L + A + + T G P+ P E+ + D G+ +P GEVG Sbjct: 323 HFGCEILDGIGSTEML--HIFLSNRAGAVEYGTTGRPV-PGYEIELRDEAGHAVPDGEVG 379 Query: 382 RLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEK 441 L +GP Y+ + + + + F + SGD P G GR D + G+ Sbjct: 380 DLYIKGPSAAVMYWNNREKSRATFLGE-WIRSGDKYCRLPNGCYVYAGRSDDMLKVSGQY 438 Query: 442 IAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVK-----EPLRAVQVRRFLREQ 496 ++ E+E +L++H AV+ AA+V ++ + K+ A++V+K + A +++ F++++ Sbjct: 439 VSPVEVEMVLVQHDAVLEAAVVGVDHGGL-VKTRAFVVLKREFAPSEILAEELKAFVKDR 497 Query: 497 GIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQ 528 +A K P + VD LP TA GK+ + +LR+ Sbjct: 498 -LAPHKYPRDIVFVDDLPKTATGKIQRFKLRE 528 >5BSW-A nrPDB Length = 541 Score = 125 bits (313), Expect = 7e-29, Method: Compositional matrix adjust. Identities = 132/503 (26%), Positives = 220/503 (43%), Gaps = 39/503 (7%) Query: 50 SYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLA--LFSH 107 +Y ++ + +A L +QGI+P +T ++ L N E F LG +A LF+ Sbjct: 54 TYADVELNSRKVAAGLHKQGIQPKDTIMILLPNSPEFVFAFIGASYLGAISTMANPLFTP 113 Query: 108 QRSELNAYASQ----IEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNL 163 A AS + A + + F D + + +L + EH++ Sbjct: 114 AEVVKQAKASSAKIIVTQACHVNKVKDYAFENDVKIICIDSAPEGCLHFSVLTQANEHDI 173 Query: 164 QDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVE----ICQ 219 + P D+V S GTTG PK + TH SV + V+ Sbjct: 174 PEVEIQP-----------DDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLY 222 Query: 220 FTQQTRYLCAIPAAHNYAMSSPGSLGVFLAG---GTVVLAADPSATLCF-PLIEKHQVNV 275 + LC +P H Y+++S V L G G +L + F LI++++V + Sbjct: 223 IHSEDVMLCVLPLFHIYSLNS-----VLLCGLRVGAAILIMQKFDIVSFLELIQRYKVTI 277 Query: 276 TALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEI-GCQLQQVFGM 334 VPP V ++ + + L+S++ + G A L L + A+ +L Q +GM Sbjct: 278 GPFVPPIVLAIAKSPMVDDY--DLSSVRTVMSGAAPLGKELEDTVRAKFPNAKLGQGYGM 335 Query: 335 AEG--LVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAE-GNPLPQGEVGRLMTRGPYTF 391 E L +I + + E+ + D + GN LP+ + G + RG Sbjct: 336 TEAGPLAMCLAFAKEPFEIKSGACGTVVRNAEMKIVDPKTGNSLPRNQSGEICIRGDQIM 395 Query: 392 RGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLL 451 +GY P+ A D G+ +GD+ ID + + + R K+ I G ++A E+E LL Sbjct: 396 KGYLNDPEATARTIDKEGWLYTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALL 455 Query: 452 LRHPAVIYAALVSMEDELMGEKSCAYLVVKE--PLRAVQVRRFLREQGIAEFKLPDRVEC 509 L HP + AA+V M+DE GE A++V + +V+ F+ +Q I +K RV Sbjct: 456 LNHPNISDAAVVPMKDEQAGEVPVAFVVRSNGSTITEDEVKDFISKQVIF-YKRIKRVFF 514 Query: 510 VDSLPLTAVGKVDKKQLRQWLAS 532 VD++P + GK+ +K LR LA+ Sbjct: 515 VDAIPKSPSGKILRKDLRAKLAA 537 >3IPL-A nrPDB Length = 501 Score = 124 bits (311), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 97/349 (27%), Positives = 164/349 (46%), Gaps = 24/349 (6%) Query: 182 DEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSP 241 D++A + GTTG K +P+T ++Y S E F + T +L +P H +S Sbjct: 163 DDIASIMFTSGTTGPQKAVPQTFRNHYASAIGCKESLGFDRDTNWLSVLPIYHISGLSV- 221 Query: 242 GSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLAS 301 L + G TV + +A +I+ ++ +LVP ++ +Q + + + Sbjct: 222 -LLRAVIEGFTVRIVDKFNAEQILTMIKNERITHISLVPQTLNWLMQ-----QGLHEPYN 275 Query: 302 LKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIH----TQGY 357 L+ + +GGA+LSAT+ + + FGM E + + +++H T G Sbjct: 276 LQKILLGGAKLSATMI-ETALQYNLPIYNSFGMTETCSQFLT---ATPEMLHARPDTVGM 331 Query: 358 PMCPDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLI 417 P D V + NP +G G LM +G GY P F+ NG++ +GD+ Sbjct: 332 PSANVD-VKIK----NPNKEGH-GELMIKGANVMNGYLY-PTDLTGTFE-NGYFNTGDIA 383 Query: 418 SIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAY 477 ID EGY+ + R KD I GGE I +IE + + P + A V D+ G+ Y Sbjct: 384 EIDHEGYVMIYDRRKDLIISGGENIYPYQIETVAKQFPGISDAVCVGHPDDTWGQVPKLY 443 Query: 478 LVVKEPLRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQL 526 V + + Q+ +L + +A++K+P E VD+LP T+ GK+ + +L Sbjct: 444 FVSESDISKAQLIAYLSKH-LAKYKVPKHFEKVDTLPYTSTGKLQRNKL 491 >1V25-A nrPDB Length = 541 Score = 120 bits (302), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 107/356 (30%), Positives = 179/356 (50%), Gaps = 28/356 (7%) Query: 192 GTTGTPKLIPRTHNDY-YYSVRRS-VEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLA 249 GTTG PK + +H +S+ S V+ +++ L +P H A P L Sbjct: 186 GTTGLPKGVVYSHRALVLHSLAASLVDGTALSEKDVVLPVVPMFHVNAWCLP--YAATLV 243 Query: 250 GGTVVLAA---DPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRA-QLASLKLL 305 G VL DP++ + L + V TA VP ++WL ES +L +L+ L Sbjct: 244 GAKQVLPGPRLDPASLV--ELFDGEGVTFTAGVP---TVWLALADYLESTGHRLKTLRRL 298 Query: 306 QVGGARLSATLAARIPAEIGCQLQQVFGMAEG----LVNYTR--LDDSAEK----IIHTQ 355 VGG+ +L AR +G +++Q +G+ E + N+ + L+ +E+ + Sbjct: 299 VVGGSAAPRSLIARF-ERMGVEVRQGYGLTETSPVVVQNFVKSHLESLSEEEKLTLKAKT 357 Query: 356 GYPMCPDDEVWVADAEGNPLPQ--GEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCS 413 G P+ P + VAD EG P+P+ +G + +GP+ GYY + + SA +GF+ + Sbjct: 358 GLPI-PLVRLRVADEEGRPVPKDGKALGEVQLKGPWITGGYYGNEEATRSALTPDGFFRT 416 Query: 414 GDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEK 473 GD+ D EGY+ ++ R KD I GGE I++ ++EN L+ HP V AA+V++ E+ Sbjct: 417 GDIAVWDEEGYVEIKDRLKDLIKSGGEWISSVDLENALMGHPKVKEAAVVAIPHPKWQER 476 Query: 474 SCAYLVVK-EPLRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQ 528 A +V + E ++ L + G A+++LPD + +P T+ GK K+ LR+ Sbjct: 477 PLAVVVPRGEKPTPEELNEHLLKAGFAKWQLPDAYVFAEEIPRTSAGKFLKRALRE 532 >3A9U-A nrPDB Length = 536 Score = 120 bits (300), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 142/543 (26%), Positives = 249/543 (45%), Gaps = 34/543 (6%) Query: 10 EEFARRYREKGYW--QDLPLTDILTRHAASDSI--AVIDGERQ--LSYRELNQAADNLAC 63 EEF R + + ++LPL + + ++ S +I+G +Y ++ A +A Sbjct: 5 EEFIFRSKLPDIYIPKNLPLHSYVLENLSNHSSKPCLINGANGDVYTYADVELTARRVAS 64 Query: 64 SLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPAL 123 L + GI+ G+ ++ L + E + F G A +EL +A L Sbjct: 65 GLNKIGIQQGDVIMLFLPSSPEFVLAFLGASHRGAIITAANPFSTPAELAKHAKASRAKL 124 Query: 124 LIADRQHALFSGDDFLNTFVTEHSSIRV--VQLLNDSGEH--NLQDAINHPAEDFTATPS 179 LI + + + F E S ++V V D H L A + A +P Sbjct: 125 LITQACYY-----EKVKDFARE-SDVKVMCVDSAPDGCLHFSELTQADENEAPQVDISP- 177 Query: 180 PADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVE----ICQFTQQTRYLCAIPAAHN 235 D+V S GTTG PK + TH SV + V+ F + LC +P H Sbjct: 178 --DDVVALPYSSGTTGLPKGVMLTHKGLITSVAQQVDGDNPNLYFHSEDVILCVLPMFHI 235 Query: 236 YAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGES 295 YA++S G+ + +++ +L LIEK++V++ +VPP + ++ Sbjct: 236 YALNSIMLCGLRVGAPILIMPKFEIGSL-LGLIEKYKVSIAPVVPPVMMSIAKS--PDLD 292 Query: 296 RAQLASLKLLQVGGARLSATLAARIPAEI-GCQLQQVFGMAE-GLVNYTRLDDSAEKIIH 353 + L+SL++++ GGA L L + A+ +L Q +GM E G V L + E Sbjct: 293 KHDLSSLRMIKSGGAPLGKELEDTVRAKFPQARLGQGYGMTEAGPVLAMCLAFAKEPFDI 352 Query: 354 TQGY--PMCPDDEVWVADAE-GNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGF 410 G + + E+ + D E G LP+ + G + RG +GY P+ + D G+ Sbjct: 353 KPGACGTVVRNAEMKIVDPETGASLPRNQPGEICIRGDQIMKGYLNDPEATSRTIDKEGW 412 Query: 411 YCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELM 470 +GD+ ID + + + R K+ I G ++A E+E LL+ HP + AA+V ++DE Sbjct: 413 LHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLIAHPEISDAAVVGLKDEDA 472 Query: 471 GEKSCAYLVVKEPLRAV--QVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQ 528 GE A++V E +A ++++++ +Q I +K RV ++++P GK+ +K L++ Sbjct: 473 GEVPVAFVVKSEKSQATEDEIKQYISKQVIF-YKRIKRVFFIEAIPKAPSGKILRKNLKE 531 Query: 529 WLA 531 LA Sbjct: 532 KLA 534 >3IVR-A nrPDB Length = 509 Score = 118 bits (295), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 142/524 (27%), Positives = 225/524 (42%), Gaps = 50/524 (9%) Query: 23 QDLPLTDILTRHAA--SDSIA-VIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQ 79 D L D+ R+AA D A ++DG R L++R+ A+ LA L R G+ G+ + Sbjct: 4 HDFTLADVYRRNAALFPDRTAFMVDGVR-LTHRDYLARAERLASGLLRDGVHTGDRVAIL 62 Query: 80 LGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFL 139 N +E+ A+ +G + + E+ P++++A G D+ Sbjct: 63 SQNCSEMIELIGAVALIGAILLPVNYRLNADEIAFVLGDGAPSVVVA--------GTDYR 114 Query: 140 NTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTA-TPSPADEVAY---FQL--SGGT 193 + S+ V+ G+ + A P +D + TP A E F + + Sbjct: 115 DIVAGVLPSLGGVKKAYAIGDGSGPFA---PFKDLASDTPFSAPEFGAADGFVIIHTAAV 171 Query: 194 TGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFL----A 249 G P+ + + + V+ + T+ L +P H LG+ L A Sbjct: 172 GGRPRGALISQGNLLIAQSSLVDAWRLTEADVNLGMLPLFHVT------GLGLMLTLQQA 225 Query: 250 GGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGG 309 GG V+AA IE H+V V A P L +++ + AQLASL+ V G Sbjct: 226 GGASVIAAKFDPAQAARDIEAHKVTVMAEFAP----MLGNILDQAAPAQLASLR--AVTG 279 Query: 310 ARLSATLAARIPAEIGCQLQQVFGMAE--GLVNYTRLDDSAEKIIHTQGYPMCPDDEVWV 367 T+ FG +E GL + D + + G P+ V V Sbjct: 280 LDTPETIERFEATCPNATFWATFGQSETSGLSTFAPYRDRPK----SAGRPLFWR-TVAV 334 Query: 368 ADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITV 427 DAE PLP GEVG ++ RGP F+GY+ + AF NG++ +GD+ D +GY+ Sbjct: 335 VDAEDRPLPPGEVGEIVLRGPTVFKGYWNNAAATQHAFR-NGWHHTGDMGRFDADGYLFY 393 Query: 428 QGR--EKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVK--EP 483 GR EK+ I GGE + E+E L +HPA+ A ++ + D E A V K E Sbjct: 394 AGRAPEKELIKTGGENVYPAEVEGALKQHPAIADAVVIGVPDPQWSEAIKAVCVCKPGES 453 Query: 484 LRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLR 527 + A + F+ IA +K P V V++LP A G +D+ ++ Sbjct: 454 IAADALAEFVASL-IARYKKPKHVVFVEALPKDAKGAIDRAAVK 496 >4EAT-A nrPDB Length = 524 Score = 117 bits (293), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 123/525 (23%), Positives = 221/525 (42%), Gaps = 54/525 (10%) Query: 32 TRHAASDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFF 91 T D A +D LS+ +L LA +LR G+K E L+ + + + + F Sbjct: 22 TNRVRPDKTAFVDDISSLSFAQLEAQTRQLAAALRAIGVKREERVLLLMLDGTDWPVAFL 81 Query: 92 ALLKLGVAPVLA-----------LFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLN 140 + G+ PV + H R++ + + P L + AL D + Sbjct: 82 GAIYAGIVPVAVNTLLTADDYAYMLEHSRAQAVLVSGALHPVL-----KAALTKSDHEVQ 136 Query: 141 TFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLI 200 + + + + GE + + + A + AD+ A++ S G+TG PK + Sbjct: 137 RVIVSRPAAPL-----EPGEVDFAEFVGAHAPLEKPAATQADDPAFWLYSSGSTGRPKGV 191 Query: 201 PRTH-NDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADP 259 TH N Y+ S + A Y + + + + + T+++ P Sbjct: 192 VHTHANPYWTSELYGRNTLHLREDDVCFSAAKLFFAYGLGNALTFPMTVGATTLLMGERP 251 Query: 260 SATLCFPLIEKHQVNVTALVPPAVSLWLQALIEG-------ESRAQLASLKLLQVGGARL 312 + F K + V P V G SR Q+A RL Sbjct: 252 TPDAVF----KRWLGGVGGVKPTVFYGAPTGYAGMLAAPNLPSRDQVA---------LRL 298 Query: 313 SATLAARIPAEIGCQLQQVFGM--AEGLVN----YTRLDDSAEKIIH-TQGYPMCPDDEV 365 +++ +PAEIG + Q+ FG+ +G+ + + L + +++ + T G+P+ P ++ Sbjct: 299 ASSAGEALPAEIGQRFQRHFGLDIVDGIGSTEMLHIFLSNLPDRVRYGTTGWPV-PGYQI 357 Query: 366 WVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYI 425 + G P+ GE G L GP + Y+ + + F G+ SGD + +G Sbjct: 358 ELRGDGGGPVADGEPGDLYIHGPSSATMYWGNRAKSRDTFQ-GGWTKSGDKYVRNDDGSY 416 Query: 426 TVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVK--EP 483 T GR D + G ++ EIE L++HP V+ AA+V + DE K AY+V + + Sbjct: 417 TYAGRTDDMLKVSGIYVSPFEIEATLVQHPGVLEAAVVGVADEHGLTKPKAYVVPRPGQT 476 Query: 484 LRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQ 528 L +++ F++++ +A +K P V LP TA GK+ + +LR+ Sbjct: 477 LSETELKTFIKDR-LAPYKYPRSTVFVAELPKTATGKIQRFKLRE 520 >3TSY-A nrPDB Length = 979 Score = 117 bits (292), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 125/499 (25%), Positives = 227/499 (45%), Gaps = 22/499 (4%) Query: 50 SYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQR 109 +Y +++ + +A + + G+ + ++ L N E ++F A G A Sbjct: 90 TYSDVHVISRQIAANFHKLGVNQNDVVMLLLPNCPEFVLSFLAASFRGATATAANPFFTP 149 Query: 110 SELNAYASQIEPALLIA-----DRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQ 164 +E+ A L+I D+ L + D + + ++ S+ + + E L Sbjct: 150 AEIAKQAKASNTKLIITEARYVDKIKPLQNDDGVVIVCIDDNESVPIPEGCLRFTE--LT 207 Query: 165 DAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVE----ICQF 220 + +E + D+V S GTTG PK + TH SV + V+ F Sbjct: 208 QSTTEASEVIDSVEISPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYF 267 Query: 221 TQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVP 280 LC +P H YA++S G+ + G +++ L LI++ +V V +VP Sbjct: 268 HSDDVILCVLPMFHIYALNSIMLCGLRV-GAAILIMPKFEINLLLELIQRCKVTVAPMVP 326 Query: 281 PAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEI-GCQLQQVFGMAE-GL 338 P V L + E E + L+S+++++ G A L L + A+ +L Q +GM E G Sbjct: 327 PIV-LAIAKSSETE-KYDLSSIRVVKSGAAPLGKELEDAVNAKFPNAKLGQGYGMTEAGP 384 Query: 339 VNYTRLDDSAEKIIHTQGY--PMCPDDEVWVADAE-GNPLPQGEVGRLMTRGPYTFRGYY 395 V L + E G + + E+ + D + G+ L + + G + RG +GY Sbjct: 385 VLAMSLGFAKEPFPVKSGACGTVVRNAEMKIVDPDTGDSLSRNQPGEICIRGHQIMKGYL 444 Query: 396 KSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHP 455 +P A D +G+ +GD+ ID + + + R K+ I G ++A E+E LL+ HP Sbjct: 445 NNPAATAETIDKDGWLHTGDIGLIDDDDELFIVDRLKELIKYKGFQVAPAELEALLIGHP 504 Query: 456 AVIYAALVSMEDELMGEKSCAYLVVKE--PLRAVQVRRFLREQGIAEFKLPDRVECVDSL 513 + A+V+M++E GE A++V + L V++F+ +Q + +K ++V +S+ Sbjct: 505 DITDVAVVAMKEEAAGEVPVAFVVKSKDSELSEDDVKQFVSKQ-VVFYKRINKVFFTESI 563 Query: 514 PLTAVGKVDKKQLRQWLAS 532 P GK+ +K LR LA+ Sbjct: 564 PKAPSGKILRKDLRAKLAN 582 >4WV3-A nrPDB Length = 529 Score = 114 bits (285), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 131/535 (24%), Positives = 225/535 (42%), Gaps = 57/535 (10%) Query: 24 DLPL----TDILTRH--AASDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETAL 77 DLPL DIL R+ ++ A+ +R++++R+++ A+ + +L+ G++ GE Sbjct: 5 DLPLYYNAVDILERNLPVRANKTALFTPDREMTFRQVSNEANQVGNALKGLGVRFGECVG 64 Query: 78 VQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIAD-RQHALFSGD 136 + + AE +FF ++KLG V +N E ++ D R L Sbjct: 65 LLTLDSAEWVTSFFGIVKLGAIAV---------GINTLLKPPEYEYILRDCRARVLIVHQ 115 Query: 137 DFL--------NTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQ 188 +FL N + EH I V+ G + D I A S +++ Sbjct: 116 EFLPLIESIRGNLPMLEH--IVVIGEGPQEGYLSFNDWIRPQPTTLEAAQSHREDICSLN 173 Query: 189 LSGGTTGTPKLIPRTHNDYYYSVR-RSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGV- 246 S GTTG PK IP H DY + + V + + R A + + G+L Sbjct: 174 YSSGTTGGPKGIPHAHKDYPLTAQLWGVNVLGLRESDRTFAL--AKLFFTFGTGGNLIFP 231 Query: 247 FLAGGTVVL--AADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKL 304 + G + VL A A+ I + + + P + L ++ S+ L+SL+L Sbjct: 232 WYVGASCVLFPGAARVASNVLSTISRFKPTIFYNAPTGYAAALA--LKDFSQHDLSSLRL 289 Query: 305 LQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYT-------RLDDSAEKIIHTQGY 357 L A L G + G E + R S + + +GY Sbjct: 290 CVSASEALPAALWYAWKEATGVDIIDGIGCTENFHIFISNRPGDIRPGSSGKPV---EGY 346 Query: 358 PMCPDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLI 417 E+ + D EG +P GE+G ++ R Y+ + + + F + +GD Sbjct: 347 ------ELKLVDDEGKTVPAGEIGNVLLRSETAALSYWHNFEKSRQTFQGE-WLATGDKY 399 Query: 418 SIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAY 477 +D +GY GR D + GG ++ E+E+ L++HPAV A++ D+ K A+ Sbjct: 400 FVDADGYYWHAGRSDDMLKVGGIWVSPVEVESTLIQHPAVQECAVIGCPDQSRLIKPKAF 459 Query: 478 LVVKE---PLRAV--QVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLR 527 +++K P A+ Q+ E+ +A +K P +E V LP TA GK+ + +LR Sbjct: 460 IILKPEQIPSEALIRQITDHCTEK-MAAYKRPRWIEFVTELPKTATGKIQRFKLR 513 >3R44-A nrPDB Length = 517 Score = 114 bits (284), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 122/495 (24%), Positives = 208/495 (42%), Gaps = 42/495 (8%) Query: 48 QLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSH 107 +++Y ++N A+ A L GI G+ + + N E F+ KLG V Sbjct: 43 RMTYAQMNALANRCADVLTALGIAKGDRVALLMPNSVEFCCLFYGAAKLGAVAV------ 96 Query: 108 QRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDS--------G 159 +N + E + +++D SG + I ++ D G Sbjct: 97 ---PINTRLAAPEVSFILSD------SGSKVVIYGAPSAPVIDAIRAQADPPGTVTDWIG 147 Query: 160 EHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQ 219 +L + + A D A D+ + + GTTG PK + TH + + Sbjct: 148 ADSLAERLRSAAADEPAVECGGDDNLFIMYTSGTTGHPKGVVHTHESVHSAASSWASTID 207 Query: 220 FTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADP--SATLCFPLIEKHQVNVTA 277 + R L +P H A+++ +F A V L + P AT + LI + +V + Sbjct: 208 VRYRDRLLLPLPMFHVAALTTV----IFSAMRGVTLISMPQFDATKVWSLIVEERVCIGG 263 Query: 278 LVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEG 337 VP ++ Q E A + GGA + L +I A ++ Q + + E Sbjct: 264 AVPAILNFMRQVPEFAELDAP--DFRYFITGGAPMPEALI-KIYAAKNIEVVQGYALTES 320 Query: 338 LVNYTRL--DDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYY 395 T L +D+ K M D V V +G GE G ++ + + Y+ Sbjct: 321 CGGGTLLLSEDALRKAGSAGRATMFTD--VAVRGDDGVIREHGE-GEVVIKSDILLKEYW 377 Query: 396 KSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHP 455 P+ AFD NG++ +GD+ ID EGY+ ++ R KD I GGE + EIE++++ P Sbjct: 378 NRPEATRDAFD-NGWFRTGDIGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVP 436 Query: 456 AVIYAALVSMEDELMGEKSCAYLVVKEPLRAVQVRRFLREQG--IAEFKLPDRVECVDSL 513 V A++ + DE GE + A +V + V ++ + G +A +KLP +V +++ Sbjct: 437 GVSEVAVIGLPDEKWGEIAAAIVVADQ--NEVSEQQIVEYCGTRLARYKLPKKVIFAEAI 494 Query: 514 PLTAVGKVDKKQLRQ 528 P GK+ K LR+ Sbjct: 495 PRNPTGKILKTVLRE 509 >4M46-A nrPDB Length = 581 Score = 105 bits (262), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 120/523 (22%), Positives = 223/523 (42%), Gaps = 53/523 (10%) Query: 39 SIAVIDG--ERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFA--LL 94 +IA D E ++Y E + A LA +++R G+ V N + ++ + Sbjct: 73 TIAFTDAHAEVNITYSEYFEMACRLAETMKRYGLGLQHHIAVCSENSLQFFMPVCGALFI 132 Query: 95 KLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQ- 153 +GVAP +++ + EL S +P ++ ++ L + + ++Q Sbjct: 133 GVGVAPTNDIYNER--ELYNSLSISQPTIVFCSKRA--------LQKILGVQKKLPIIQK 182 Query: 154 -LLNDS-----GEHNLQDAINH--PA--EDFTATPSPADE---VAYFQLSGGTTGTPKLI 200 ++ DS G+ ++ I PA ++ P D A S G+TG PK + Sbjct: 183 IVILDSREDYMGKQSMYSFIESHLPAGFNEYDYIPDSFDRETATALIMNSSGSTGLPKGV 242 Query: 201 PRTHNDY---YYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAA 257 TH + + R V Q T L IP H + M + +LG G +VL Sbjct: 243 ELTHKNICVRFSHCRDPVFGNQIIPDTAILTVIPFHHGFGMFT--TLGYLTCGFRIVLMY 300 Query: 258 DPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLA 317 L ++ +++ LVP S + ++ + + L++L + GGA L+ Sbjct: 301 RFEEELFLRSLQDYKIQSALLVPTLFSFFAKSTLV--DKYDLSNLHEIASGGAPLAK--- 355 Query: 318 ARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQG-------YPMCPDDEVWVADA 370 E+G + + F + Y + ++ II +G + P + D Sbjct: 356 -----EVGEAVAKRFKLPGIRQGYGLTETTSAIIITPEGDDKPGACGKVVPFFSAKIVDL 410 Query: 371 E-GNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQG 429 + G L + G L +GP +GY +P+ ++ D +G+ SGD+ D +G+ + Sbjct: 411 DTGKTLGVNQRGELCVKGPMIMKGYVNNPEATSALIDKDGWLHSGDIAYYDKDGHFFIVD 470 Query: 430 REKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKE--PLRAV 487 R K I G ++ E+E++LL+HP + A + + D GE A +V++E + Sbjct: 471 RLKSLIKYKGYQVPPAELESILLQHPFIFDAGVAGIPDPDAGELPAAVVVLEEGKTMTEQ 530 Query: 488 QVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWL 530 +V ++ Q A +L V+ VD +P GK+D +++R+ L Sbjct: 531 EVMDYVAGQVTASKRLRGGVKFVDEVPKGLTGKIDARKIREIL 573 >3DLP-X nrPDB Length = 504 Score = 102 bits (255), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 126/503 (25%), Positives = 205/503 (40%), Gaps = 45/503 (8%) Query: 48 QLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLA---L 104 +L++ EL + +A L G++P + V N A++ I AL +LG P L L Sbjct: 29 RLTHAELRARVEAVAARLHADGLRPQQRVAVVAPNSADVVIAILALHRLGAVPALLNPRL 88 Query: 105 FSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQ 164 S + +EL ++ A++ RQ A + S R++ L D Sbjct: 89 KSAELAEL-IKRGEMTAAVIAVGRQVA--------DAIFQSGSGARII-FLGDLVRDGEP 138 Query: 165 DAINHPAEDFTATPSPADEVAYFQLSGGTTGTPK--LIPRTHNDYYYSVRRSVEICQFTQ 222 + P ED P+ + A+ + GTTG PK +IP+ + + + + Sbjct: 139 YSYGPPIEDPQREPA---QPAFIFYTSGTTGLPKAAIIPQRAAESRVLFMSTQVGLRHGR 195 Query: 223 QTRYLCAIPAAHNYAMSSPGSLGVFLAG----GTVVLAADPSATLCFPLIEKHQVNVTAL 278 L +P H G V +A GT V+ + L+++ QV Sbjct: 196 HNVVLGLMPLYHVV-----GFFAVLVAALALDGTYVVVEEFRPVDALQLVQQEQVTSLFA 250 Query: 279 VPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGL 338 P + A S +L SL+ + GA + + + + + ++G E + Sbjct: 251 TPTHLDALAAAAAHAGSSLKLDSLRHVTFAGATMPDAVLETVHQHLPGEKVNIYGTTEAM 310 Query: 339 VN-YTRLDDSAEKIIHTQGYPMCPD--DEVWVADAEGNP---LPQGEVGRLMTRGPYT-F 391 + Y R + G M P EV + G + GE G L+ + F Sbjct: 311 NSLYMRQPKT--------GTEMAPGFFSEVRIVRIGGGVDEIVANGEEGELIVAASDSAF 362 Query: 392 RGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLL 451 GY PQ A +G+Y + D+ PEG + + GR D I GGE I EIE +L Sbjct: 363 VGYLNQPQATAEKLQ-DGWYRTSDVAVWTPEGTVRILGRVPDMIISGGENIHPSEIERVL 421 Query: 452 LRHPAVIYAALVSMEDELMGEKSCAYLV--VKEPLRAVQVRRFLREQGIAEFKLPDRVEC 509 P V ++ + D+ G+ A +V + E L A + F R +A+FK P R Sbjct: 422 GTAPGVTEVVVIGLADQRWGQSVTACVVPRLGETLSADALDTFCRSSELADFKRPKRYFI 481 Query: 510 VDSLPLTAVGKVDKKQLRQWLAS 532 +D LP A+ KV ++QL Q ++S Sbjct: 482 LDQLPKNALNKVLRRQLVQQVSS 504 >3GPC-A nrPDB Length = 570 Score = 101 bits (252), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 124/518 (23%), Positives = 218/518 (42%), Gaps = 67/518 (12%) Query: 46 ERQLSYRELN----QAADNL--ACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVA 99 E ++REL+ QAA+ L AC L+R G+ V L V E ++ ++ G+ Sbjct: 71 ELMWNFRELSENSQQAANVLSGACGLQR-----GDRVAVVLPRVPEWWLVILGCIRAGLI 125 Query: 100 PVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFL---NTFVTEHSSIRVVQLLN 156 + + +++ Y Q+ A A+ +GD+ + +T +E S+R+ L++ Sbjct: 126 FMPGTIQMKSTDI-LYRLQMSKA-------KAIVAGDEVIQEVDTVASECPSLRIKLLVS 177 Query: 157 DS---GEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHN-------- 205 + G N + +N + + + E + + GT+G PK+ +++ Sbjct: 178 EKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAKM 237 Query: 206 DYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLCF 265 D ++ ++ +I T ++ I + + P +LG A V L + Sbjct: 238 DAGWTGLQASDIMWTISDTGWILNILCS----LMEPWALG---ACTFVHLLPKFDPLVIL 290 Query: 266 PLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIG 325 + + + P + LQ + L + + VG + L TL A+ G Sbjct: 291 KTLSSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNC--VTVGESLLPETLE-NWRAQTG 347 Query: 326 CQLQQVFGMAEGLVNYTRLDDSAEKIIHTQ-GY----PMCPDDEVWVADAEGNPLPQGEV 380 +++ +G E T L K + + GY C D V + D +GN LP G Sbjct: 348 LDIRESYGQTE-----TGLTCMVSKTMKIKPGYMGTAASCYD--VQIIDDKGNVLPPGTE 400 Query: 381 GRLMTR-GPY----TFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQI 435 G + R P F GY +P A+ + F+ GD D +GY GR D I Sbjct: 401 GDIGIRVKPIRPIGIFSGYVDNPDKTAANIRGD-FWLLGDRGIKDEDGYFQFMGRADDII 459 Query: 436 NRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKEPLRAVQVRRFLRE 495 N G +I E+EN L+ HPAV+ A++S D + GE A++V+ + + +E Sbjct: 460 NSSGYRIGPSEVENALMEHPAVVETAVISSPDPVRGEVVKAFVVLASQFLSHDPEQLTKE 519 Query: 496 ------QGIAEFKLPDRVECVDSLPLTAVGKVDKKQLR 527 A +K P ++E V +LP T GK+ + +LR Sbjct: 520 LQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRAKLR 557 >5DWV-A nrPDB Length = 573 Score = 101 bits (252), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 120/522 (22%), Positives = 220/522 (42%), Gaps = 51/522 (9%) Query: 39 SIAVIDG--ERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKL 96 +IA D E ++Y E + + LA +++R G+ +V N + ++ L + Sbjct: 62 TIAFTDAHIEVNITYAEYFEMSVRLAEAMKRYGLNTNHRIVVCSENSLQFFMPVLGALFI 121 Query: 97 GVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQ--L 154 GVA A + EL + +P ++ ++ L + + ++Q + Sbjct: 122 GVAVAPANDIYNERELLNSMNISQPTVVFVSKKG--------LQKILNVQKKLPIIQKII 173 Query: 155 LNDS-----GEHNLQDAINH---PA-EDFTATPSPADE---VAYFQLSGGTTGTPK---L 199 + DS G ++ + P ++ P D +A S G+TG PK L Sbjct: 174 IMDSKTDYQGFQSMYTFVTSHLPPGFNEYDFVPESFDRDKTIALIMNSSGSTGLPKGVAL 233 Query: 200 IPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADP 259 RT + R + Q T L +P H + M + +LG + G VVL Sbjct: 234 PHRTACVRFSHARDPIFGNQIIPDTAILSVVPFHHGFGMFT--TLGYLICGFRVVLMYRF 291 Query: 260 SATLCFPLIEKHQVNVTALVPPAVSLWLQA-LIEGESRAQLASLKLLQVGGARLSATLAA 318 L ++ +++ LVP S + ++ LI+ + L++L + GGA LS Sbjct: 292 EEELFLRSLQDYKIQSALLVPTLFSFFAKSTLID---KYDLSNLHEIASGGAPLSK---- 344 Query: 319 RIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQG-------YPMCPDDEVWVADAE 371 E+G + + F + Y + ++ +I +G + P E V D + Sbjct: 345 ----EVGEAVAKRFHLPGIRQGYGLTETTSAILITPEGDDKPGAVGKVVPFFEAKVVDLD 400 Query: 372 -GNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGR 430 G L + G L RGP GY +P+ + D +G+ SGD+ D + + + R Sbjct: 401 TGKTLGVNQRGELCVRGPMIMSGYVNNPEATNALIDKDGWLHSGDIAYWDEDEHFFIVDR 460 Query: 431 EKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVK--EPLRAVQ 488 K I G ++A E+E++LL+HP + A + + D+ GE A +V++ + + + Sbjct: 461 LKSLIKYKGYQVAPAELESILLQHPNIFDAGVAGLPDDDAGELPAAVVVLEHGKTMTEKE 520 Query: 489 VRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWL 530 + ++ Q KL V VD +P GK+D +++R+ L Sbjct: 521 IVDYVASQVTTAKKLRGGVVFVDEVPKGLTGKLDARKIREIL 562 >4LGC-A nrPDB Length = 539 Score = 100 bits (249), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 125/509 (24%), Positives = 210/509 (41%), Gaps = 46/509 (9%) Query: 38 DSIAVI--DGERQLS---YRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFA 92 DS AVI D E+ S + +L+ + LA L I PG L N E I FA Sbjct: 64 DSTAVICLDKEQNCSVITWHQLHVYSSQLAWYLIENEIGPGSIVLTMFPNSIEHIIAVFA 123 Query: 93 LLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVV 152 + K G + + SE+ I P A+ + G F S+ + Sbjct: 124 IWKAGACYMPMSYKAAESEIREACDTIHPNAAFAECK---IPGLKFC------LSADEIY 174 Query: 153 QLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLI----PRTHNDYY 208 + + + D + +P LSGGT+G K I P +D Sbjct: 175 EAMEGRSKEMPSDRLANPN--------------MISLSGGTSGKMKFIRQNLPCGLDDE- 219 Query: 209 YSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLCFPLI 268 ++R + + R L P H A S G+F+ G T+VL + +I Sbjct: 220 -TIRSWSLMSGMGFEQRQLLVGPLFHG-APHSAAFNGLFM-GNTLVLTRNLCPGNILNMI 276 Query: 269 EKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIGCQ- 327 +K+++ +VP ++ A +EG + ASLK L G S L +G + Sbjct: 277 KKYKIEFIQMVPTLMNR--LAKLEGVGKEDFASLKALCHTGGVCSPWLKQIWIDLLGPEK 334 Query: 328 LQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMTRG 387 + +++ M E + D K + G P+ D +V + D G + E+G + Sbjct: 335 IYEMYSMTECIGLTCIRGDEWVKHPGSIGRPV-GDSKVSIRDENGKEVAPFEIGEIYMTA 393 Query: 388 PYTFRGYYKSPQHNASAFDAN--GFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAE 445 P + Y + N + GF GD+ +D +GY+ R D + GGE + A Sbjct: 394 PAS---YLVTEYINWEPLEVKEGGFRSVGDIGYVDEQGYLYFSDRRSDMLVSGGENVFAT 450 Query: 446 EIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKEPLRAVQVRRFLREQGIAEFKLPD 505 E+E LLR+ ++ A +V + DE +G + A + + + A +++ FLR+ + +K+P Sbjct: 451 EVETALLRYKDILDAVVVGIPDEDLGRRLHAVIETGKEIPAEELKTFLRKY-LTPYKIPK 509 Query: 506 RVECVDSLPLTAVGKVDKKQLRQWLASRA 534 E V S+ GK D+K++ + +R Sbjct: 510 TFEFVRSIRRGDNGKADRKRILEDCIARG 538 >5JRH-A nrPDB Length = 660 Score = 95.1 bits (235), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 129/540 (23%), Positives = 215/540 (39%), Gaps = 72/540 (13%) Query: 47 RQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGV--APVLAL 104 + +SYREL++ A +L GIK G+ + + V E + A ++G + + Sbjct: 106 KHISYRELHRDVCRFANTLLDLGIKKGDVVAIYMPMVPEAAVAMLACARIGAVHSVIFGG 165 Query: 105 FSHQRSELNAYASQI--EPALLIADRQHALFSG---------DDFL---NTFVTEHSSIR 150 FS + A A +I + L+ + +G DD L N EH Sbjct: 166 FSPE-----AVAGRIIDSSSRLVITADEGVRAGRSIPLKKNVDDALKNPNVTSVEH---- 216 Query: 151 VVQLLNDSGEHNLQDAINHPAEDFTATPSP--------ADEVAYFQLSGGTTGTPKLIPR 202 V+ L + + Q+ + D SP A++ + + G+TG PK + Sbjct: 217 VIVLKRTGSDIDWQEGRDLWWRDLIEKASPEHQPEAMNAEDPLFILYTSGSTGKPKGVLH 276 Query: 203 THNDY-YYSVRRSVEICQFTQQTRYLCAIP----AAHNYAMSSPGSLGVFLAGGTVVLAA 257 T Y Y+ + + Y C H+Y + P + G T++ Sbjct: 277 TTGGYLVYAATTFKYVFDYHPGDIYWCTADVGWVTGHSYLLYGPLACGAT----TLMFEG 332 Query: 258 DPS----ATLCFPLIEKHQVNVTALVPPAVSLWL---QALIEGESRAQLASLKLLQVGGA 310 P+ A +C +++KHQVN+ P A+ + IEG R+ SL++L G Sbjct: 333 VPNWPTPARMC-QVVDKHQVNILYTAPTAIRALMAEGDKAIEGTDRS---SLRILGSVGE 388 Query: 311 RLSATLAARIPAEIG---CQLQQVFGMAE-GLVNYTRLDDSAEKIIHTQGYPMCPDDEVW 366 ++ +IG C + + E G T L + E + P Sbjct: 389 PINPEAWEWYWKKIGKEKCPVVDTWWQTETGGFMITPLPGAIELKAGSATRPFFGVQPA- 447 Query: 367 VADAEGNPLPQGEVGRLMTRGPYT------FRGYYKSPQHNASAFDANGFYCSGDLISID 420 + D EG+P G L+ + F + + Q S F Y SGD D Sbjct: 448 LVDNEGHPQEGATEGNLVITDSWPGQARTLFGDHERFEQTYFSTF--KNMYFSGDGARRD 505 Query: 421 PEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVV 480 +GY + GR D +N G ++ EIE+ L+ HP + AA+V + + G+ AY+ + Sbjct: 506 EDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKIAEAAVVGIPHAIKGQAIYAYVTL 565 Query: 481 KE-----PLRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLASRAS 535 P +VR ++R++ I PD + DSLP T GK+ ++ LR+ A S Sbjct: 566 NHGEEPSPELYAEVRNWVRKE-IGPLATPDVLHWTDSLPKTRSGKIMRRILRKIAAGDTS 624 >4R0M-B nrPDB Length = 643 Score = 94.0 bits (232), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 130/509 (25%), Positives = 225/509 (44%), Gaps = 44/509 (8%) Query: 50 SYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQR 109 SY++L Q A + L ++GIK G ++Q+ + +A G+ PV + Sbjct: 47 SYQDLYQDALVILNGLEQKGIKLGHKVILQIAKNQDFIPALWACFLGGIIPVPLTVAPSY 106 Query: 110 SELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQDAINH 169 N+ ++E I D + L D L T + + + ++ + L+ A + Sbjct: 107 DLENSAVKKLENVWKILD--NPLILSDSELITEIEKLGTYSHLEGWQVISVNELRKAPSK 164 Query: 170 PAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCA 229 + P A A + G+TG PK + TH++ +V + FTQQ L Sbjct: 165 IEQLPILDPQDA---ALLLFTSGSTGMPKGVILTHHNILSMTAGTVVMNHFTQQEVTLNW 221 Query: 230 IPAAHNYAMSSPGSLGVFLAGGTV-----VLAADPSATLCFPLIEKHQVNVTALVPPAVS 284 +P H A+ G + V LA + ++ P L LI+KHQV+++ A S Sbjct: 222 MPLDHVGAIVFLGIMAVDLACDQIHVPMELVLRQPLQWL--ELIQKHQVSISWSPNFAFS 279 Query: 285 LWLQALIEGESRA-QLASLKLLQVGGARLSATLAARIPAEI--GCQLQQ-----VFGMAE 336 L Q E + + L+S+K L G ++S R+ EI QLQ+ FGM E Sbjct: 280 LINQQAEELKHVSYNLSSMKFLVNAGEQVSVK-TIRLFLEILEKHQLQERAIKPAFGMTE 338 Query: 337 GLVNYT------RLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMTRGPYT 390 T + + + E + G P+ P + + D E NPLP+ E+GRL +G Sbjct: 339 SCSGITWSAGLSKNELTEENSFVSLGKPI-PGATIRIVDQENNPLPEREIGRLQIQGNSV 397 Query: 391 FRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENL 450 +GYY + + N F G++ +GDL + +G + + GREK +I G A E+E Sbjct: 398 TKGYYNNNELNQEVFQ-EGWFTTGDLGYLS-KGELFITGREKQEIIINGVNYFAHELETT 455 Query: 451 LLRHPAVI--YAALVSMEDELMGEKSCAYLVV------KEPLRAVQVRRFLREQGIAEFK 502 + V Y A ++ D+ + L++ ++ + ++V R +R +F Sbjct: 456 IEELEGVKVSYTAAFAVFDQ---SRETDLLIITFSPESEQFEQGIKVVRKIRSHVTQKFG 512 Query: 503 L-PDRVECVDS--LPLTAVGKVDKKQLRQ 528 + P V ++ +P T++GKV K +L++ Sbjct: 513 IAPAYVIPLERNLVPKTSIGKVQKSKLKK 541 >2D1S-A nrPDB Length = 548 Score = 92.4 bits (228), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 123/539 (22%), Positives = 227/539 (42%), Gaps = 61/539 (11%) Query: 27 LTDILTRHAASDSIAVIDGERQL--SYRELNQAADNLACSLRRQG-IKPGETALVQLGNV 83 L + R+A +IA + + SY E + + L +L+ G + G AL N Sbjct: 29 LRKYMERYAKLGAIAFTNAVTGVDYSYAEYLEKSCCLGKALQNYGLVVDGRIALCS-ENC 87 Query: 84 AELYITFFA--LLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNT 141 E +I A + +GVAP +++ + EL +P ++ + ++ G D + T Sbjct: 88 EEFFIPVIAGLFIGVGVAPTNEIYTLR--ELVHSLGISKPTIVFSSKK-----GLDKVIT 140 Query: 142 FVTEHSSIRVVQLLNDS----GEHNLQDAI--NHP----AEDF-TATPSPADEVAYFQLS 190 ++I+ + +L+ G L I N P A F T ++VA S Sbjct: 141 VQKTVTTIKTIVILDSKVDYRGYQCLDTFIKRNTPPGFQASSFKTVEVDRKEQVALIMNS 200 Query: 191 GGTTGTPKLIPRTHNDY---YYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVF 247 G+TG PK + TH + + R + Q + T L +P H + M + +LG Sbjct: 201 SGSTGLPKGVQLTHENIVTRFSHARDPIYGNQVSPGTAVLTVVPFHHGFGMFT--TLGYL 258 Query: 248 LAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQV 307 + G VV+ ++ ++ LVP ++ ++ E ++ L++L + Sbjct: 259 ICGFRVVMLTKFDEETFLKTLQDYKCTSVILVPTLFAILNKS--ELLNKYDLSNLVEIAS 316 Query: 308 GGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWV 367 GGA LS E+G + + F + Y + ++ II +G D+ Sbjct: 317 GGAPLSK--------EVGEAVARRFNLPGVRQGYGLTETTSAIIITPEG------DDKPG 362 Query: 368 ADAEGNPLPQGEV--------------GRLMTRGPYTFRGYYKSPQHNASAFDANGFYCS 413 A + PL + +V G + +GP +GY +P+ D G+ + Sbjct: 363 ASGKVVPLFKAKVIDLDTKKSLGPNRRGEVCVKGPMLMKGYVNNPEATKELIDEEGWLHT 422 Query: 414 GDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEK 473 GD+ D E + + R K I G ++ E+E++LL+HP++ A + + D + GE Sbjct: 423 GDIGYYDEEKHFFIVDRLKSLIKYKGYQVPPAELESVLLQHPSIFDAGVAGVPDPVAGEL 482 Query: 474 SCAYLVVK--EPLRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWL 530 A +V++ + + +V ++ Q +L V VD +P GK+D + +R+ L Sbjct: 483 PGAVVVLESGKNMTEKEVMDYVASQVSNAKRLRGGVRFVDEVPKGLTGKIDGRAIREIL 541 >3L8C-A nrPDB Length = 521 Score = 92.0 bits (227), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 124/527 (23%), Positives = 211/527 (40%), Gaps = 78/527 (14%) Query: 45 GERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLAL 104 GER+ +Y +L + +D++A + + LV ++ TF AL K G A + Sbjct: 27 GERR-TYGQLKRDSDSIAAFIDSLALLAKSPVLVFGAQTYDMLATFVALTKSGHAYIPVD 85 Query: 105 FSHQRSELNAYASQIEPALLIADRQHAL-FSGDDFLNTFVTEHSSIRVVQLLNDSGEHNL 163 + A +P+L+IA + L G ++ ++E S ++ ++ + H++ Sbjct: 86 VHSAPERILAIIEIAKPSLIIAIEEFPLTIEGISLVS--LSEIESAKLAEMPYER-THSV 142 Query: 164 QDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFT-- 221 + D+ Y + GTTG PK + +H++ +E F Sbjct: 143 K----------------GDDNYYIIFTSGTTGQPKGVQISHDNLLSFTNWMIEDAAFDVP 186 Query: 222 QQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVV-----LAADPSATLCFPLIEKHQVNVT 276 +Q + L P +++ +S GGT+ L AD F I + V + Sbjct: 187 KQPQMLAQPP--YSFDLSVMYWAPTLALGGTLFALPKELVAD--FKQLFTTIAQLPVGIW 242 Query: 277 ALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARI--------------PA 322 P + + L + +A++ +L G L+ + A ++ P Sbjct: 243 TSTPSFADMAM--LSDDFCQAKMPALTHFYFDGEELTVSTARKLFERFPSAKIINAYGPT 300 Query: 323 EIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGR 382 E L + E + NYTRL GYP PD ++ D +G L GE G Sbjct: 301 EATVALSAIEITREMVDNYTRL---------PIGYPK-PDSPTYIIDEDGKELSSGEQGE 350 Query: 383 LMTRGPYTFRGYYKSPQHNASA---FDANGFYCSGDLISIDPEGYITVQGREKDQINRGG 439 ++ GP +GY +P+ A A F Y +GD+ S+ + + GR QI G Sbjct: 351 IIVTGPAVSKGYLNNPEKTAEAFFTFKGQPAYHTGDIGSLTEDNILLYGGRLDFQIKYAG 410 Query: 440 EKIAAEEIENLLLRHPAVIYAALV-SMEDELMGEKSCAYLVVKEPLRAVQVRRFLRE--- 495 +I E++ L + P V A V E + AY+VVK+ ++ RF RE Sbjct: 411 YRIELEDVSQQLNQSPMVASAVAVPRYNKEHKVQNLLAYIVVKDGVK----ERFDRELEL 466 Query: 496 ---------QGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLASR 533 + + +P + DSLPLT GK+D K L + +R Sbjct: 467 TKAIKASVKDHMMSYMMPSKFLYRDSLPLTPNGKIDIKTLINEVNNR 513 >3ETC-A nrPDB Length = 580 Score = 87.8 bits (216), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 117/505 (23%), Positives = 204/505 (40%), Gaps = 35/505 (6%) Query: 46 ERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALF 105 E+ ++++L +D A + GI G+ ++ L + + + L KLG V A Sbjct: 84 EKIFTFKDLKYYSDKAANFFVKHGIGKGDYVMLTLKSRYDFWYCMLGLHKLGAIAVPATH 143 Query: 106 SHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLN-DSGEHNLQ 164 + ++ +IE A L + + DD H+ + L G L+ Sbjct: 144 MLKTRDI---VYRIEKAGL---KMIVCIAEDDVPEQVDEAHAECGDIPLKKAKVGGDVLE 197 Query: 165 DAINHPAEDFTATP----------SPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRS 214 I+ E ++P + +++ S GT G PK++ N Y + Sbjct: 198 GWIDFRKELEESSPIFERPTGEVSTKNEDICLVYFSSGTAGFPKMVEHD-NTYPLGHILT 256 Query: 215 VEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIEK-HQV 273 + Q + L A + G L G V D ++EK + Sbjct: 257 AKYWQNVEDDG-LHYTVADSGWGKCVWGKLYGQWIAGCAVFVYDYDRFEAKNMLEKASKY 315 Query: 274 NVTALV-PPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIGCQLQQVF 332 VT PP + +L + E S ++LK V G L+ + R G +L + F Sbjct: 316 GVTTFCAPPTIYRFL--IKEDLSHYNFSTLKYAVVAGEPLNPEVFNRFLEFTGIKLMEGF 373 Query: 333 GMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGRL----MTRGP 388 G E +V E + G P P ++ + D +G GE G + M P Sbjct: 374 GQTETVVTIATFP-WMEPKPGSIGKP-TPGYKIELMDRDGRLCEVGEEGEIVINTMEGKP 431 Query: 389 Y-TFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEI 447 F Y K P+ + +G+Y +GD+ +D +GY+ GR D I G K+ E+ Sbjct: 432 VGLFVHYGKDPERTEETW-HDGYYHTGDMAWMDEDGYLWFVGRADDIIKTSGYKVGPFEV 490 Query: 448 ENLLLRHPAVIYAALVSMEDELMGEKSCAYLVV-KEPLRAVQVRRFLREQ---GIAEFKL 503 E+ L++HPAV+ A+ + D + G+ A +V+ K+ + ++ L++ A +K Sbjct: 491 ESALIQHPAVLECAITGVPDPVRGQVIKATIVLTKDYTPSDSLKNELQDHVKNVTAPYKY 550 Query: 504 PDRVECVDSLPLTAVGKVDKKQLRQ 528 P +E V LP T GK+ + ++R Sbjct: 551 PRIIEFVPELPKTISGKIRRVEIRD 575 >4GR5-A nrPDB Length = 570 Score = 85.1 bits (209), Expect = 7e-17, Method: Compositional matrix adjust. Identities = 126/514 (24%), Positives = 201/514 (39%), Gaps = 59/514 (11%) Query: 36 ASDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLK 95 A D++A++ +L+Y LN+ A+ LA L G+ PG V L ++ + A+LK Sbjct: 88 APDAVALLHEADELTYGALNERANRLAHRLVGLGVAPGTLVGVHLERGFDMVVALLAVLK 147 Query: 96 LGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLL 155 G + L LL+ R L+ +T +++ V Sbjct: 148 AGGGYTMLDPQFPVERLALSLEDTGAPLLVTSRP---------LSGRLTGTTTLYVED-- 196 Query: 156 NDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSV 215 + A + PA + P D VA + G+TG PK + H Sbjct: 197 --------EAASDAPAGNLATGVGPED-VACVMFTSGSTGRPKGVMSPHR-ALTGTYLGQ 246 Query: 216 EICQFTQQTRYLCAIPAAHN-YAMSSPGSLGVFLAGGTVVLAA--DPSATLCFPLIEKHQ 272 + F +L P + + + + G L G VL + +P L+ +H Sbjct: 247 DYAGFGPDEVFLQCSPVSWDAFGLEL---FGALLFGARCVLQSGQNPDPLEIGELVARHG 303 Query: 273 VNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARI----PAEIGCQL 328 V + L S L + E ++ GG S A+ PA +L Sbjct: 304 VTMLQL-----SASLFNFLVDEVPEAFEGVRYAITGGEPASVPHVAKARRDHPA---LRL 355 Query: 329 QQVFGMAEGLVNYTRLDDSAEKIIHTQ---GYPMCPDDEVWVADAEGNPLPQGEVGRLMT 385 +G AE + T A + T G P+ +V D + P G +G L Sbjct: 356 GNGYGPAESMGFTTHHAVVAGDLSGTALPIGVPLA-GKRAYVLDDDLKPAANGALGELYV 414 Query: 386 RGPYTFRGYYKSPQHNASAFDANGF--------YCSGDLISIDPEGYITVQGREKDQINR 437 G GY P A F A+ F Y +GDL +G + GR DQ+ Sbjct: 415 AGAGLAHGYVSRPALTAERFVADPFAGPGGERMYRTGDLARRRADGVLEYVGRADDQVKI 474 Query: 438 GGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKE---PLRAVQVRRFLR 494 G ++ E+E L+ HPAV AA+++ + L ++ AY+V + P A ++RR + Sbjct: 475 RGFRVEPGEVEARLVGHPAVRQAAVLAQDSRLGDKQLVAYVVAERADAPPDAAELRRHVA 534 Query: 495 EQGIAEFKLPDRVEC--VDSLPLTAVGKVDKKQL 526 E + + +P VEC VD LP T GK+D++ L Sbjct: 535 EA-LPAYMVP--VECVPVDELPRTPNGKLDRRAL 565 >1RY2-A nrPDB Length = 663 Score = 83.6 bits (205), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 119/541 (21%), Positives = 217/541 (40%), Gaps = 68/541 (12%) Query: 48 QLSYRELNQAADNLACSLR-RQGIKPGETALVQLGNVAELYITFFALLKLGV--APVLAL 104 ++Y+EL + +A L G++ G+T V + V E IT A+ ++G + V A Sbjct: 113 SITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAG 172 Query: 105 FSHQ--RSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHN 162 FS R +N S++ ++R + ++ + E +R V + + +N Sbjct: 173 FSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKT--NN 230 Query: 163 LQDAINHPAE------------DFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYS 210 A + P + + TP +++ + + G+TG PK + + Y Sbjct: 231 PSVAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLG 290 Query: 211 VRRSVEICQFTQQTRYL-----CAIPAAHNYAMSSPGSLGVFLAGGTVVLA---ADPSAT 262 ++ T Q H Y + P + T+V A P+ + Sbjct: 291 ALLTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYGP----LLYGCATLVFEGTPAYPNYS 346 Query: 263 LCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPA 322 + +I++H+V + P A+ L +A G+S + SLK L R ++ I A Sbjct: 347 RYWDIIDEHKVTQFYVAPTALRLLKRA---GDSYIENHSLKSL-----RCLGSVGEPIAA 398 Query: 323 EIGCQLQQVFGMAE-GLVNYTRLDDSAEKIIH------------TQGYPMCPDDEVWVAD 369 E+ + G E +V+ +S ++ + +P D V + Sbjct: 399 EVWEWYSEKIGKNEIPIVDTYWQTESGSHLVTPLAGGVTPMKPGSASFPFFGIDAVVLDP 458 Query: 370 AEGNPLPQGEV-GRLMTRG--PYTFRGYYKSPQHNASAF--DANGFYCSGDLISIDPEGY 424 G L G L + P R +K+ + G+Y +GD + D +GY Sbjct: 459 NTGEELNTSHAEGVLAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGAAKDKDGY 518 Query: 425 ITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVK--- 481 I + GR D +N G +++ EIE ++ P V A+V D+L G+ A++V+K Sbjct: 519 IWILGRVDDVVNVSGHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKS 578 Query: 482 -------EPLRAVQVRR-FLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLASR 533 + L+ ++ F + I F P + VD LP T GK+ ++ LR+ LA Sbjct: 579 SWSTATDDELQDIKKHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRKILAGE 638 Query: 534 A 534 + Sbjct: 639 S 639 >5ES6-A nrPDB Length = 685 Score = 81.6 bits (200), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 115/506 (22%), Positives = 199/506 (39%), Gaps = 62/506 (12%) Query: 38 DSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLG 97 D +AV+D + L+Y++LN+ A+ LA LR +G+KP + + L ++ ++ A++K G Sbjct: 218 DHVAVVDRGQSLTYKQLNERANQLAHHLRGKGVKPDDQVAIMLDKSLDMIVSILAVMKAG 277 Query: 98 VA--PVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLL 155 A P+ + +R A ++AD A+ L + E + ++ Sbjct: 278 GAYVPIDPDYPGERI-----------AYMLADSSAAIL-----LTNALHEEKANGACDII 321 Query: 156 N----DSGEHNLQD--AINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYY 209 + DS N + +N P D++ Y + G+TG K + H++ Sbjct: 322 DVHDPDSYSENTNNLPHVNRP-----------DDLVYVMYTSGSTGLAKGVMIEHHNL-- 368 Query: 210 SVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIE 269 V C++ + Y PA SS G L T +LA +A P Sbjct: 369 -----VNFCEWYRP--YFGVTPADKALVYSSFSFDGSALDIFTHLLAG--AALHIVPSER 419 Query: 270 KHQVNVTALVPPAVSLWLQALIEG--ESRAQL--ASLKLLQVGGARLSATLAARIPAEIG 325 K+ ++ + + L G E Q+ S +++ GG L +I Sbjct: 420 KYDLDALNDYCNQEGITISYLPTGAAEQFMQMDNQSFRVVITGGDVLK-----KIERNGT 474 Query: 326 CQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMT 385 +L +G E + T + G P+ + + D P G G L Sbjct: 475 YKLYNGYGPTECTIMVTMFEVDKPYANIPIGKPI-DRTRILILDEALALQPIGVAGELFI 533 Query: 386 RGPYTFRGYYKSPQHNASAF-----DANGFYCSGDLISIDPEGYITVQGREKDQINRGGE 440 G RGY P+ A F Y +GD P+G I GR + + G Sbjct: 534 VGEGLGRGYLNRPELTAEKFIVHPQTGERMYRTGDRARFLPDGNIEFLGRLDNLVKIRGY 593 Query: 441 KIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKEPLRAVQVRRFLREQGIAE 500 +I EIE L+ HP + +++ E + Y V E + ++R +L + + Sbjct: 594 RIEPGEIEPFLMNHPLIELTTVLAKEQADGRKYLVGYYVAPEEIPHGELREWLGND-LPD 652 Query: 501 FKLPDRVECVDSLPLTAVGKVDKKQL 526 + +P + + PLTA GKVD++ L Sbjct: 653 YMIPTYFVHMKAFPLTANGKVDRRAL 678 >5ES8-A nrPDB Length = 776 Score = 81.3 bits (199), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 115/506 (22%), Positives = 199/506 (39%), Gaps = 62/506 (12%) Query: 38 DSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLG 97 D +AV+D + L+Y++LN+ A+ LA LR +G+KP + + L ++ ++ A++K G Sbjct: 218 DHVAVVDRGQSLTYKQLNERANQLAHHLRGKGVKPDDQVAIMLDKSLDMIVSILAVMKAG 277 Query: 98 VA--PVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLL 155 A P+ + +R A ++AD A+ L + E + ++ Sbjct: 278 GAYVPIDPDYPGERI-----------AYMLADSSAAIL-----LTNALHEEKANGACDII 321 Query: 156 N----DSGEHNLQD--AINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYY 209 + DS N + +N P D++ Y + G+TG K + H++ Sbjct: 322 DVHDPDSYSENTNNLPHVNRP-----------DDLVYVMYTSGSTGLAKGVMIEHHNL-- 368 Query: 210 SVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIE 269 V C++ + Y PA SS G L T +LA +A P Sbjct: 369 -----VNFCEWYRP--YFGVTPADKALVYSSFSFDGSALDIFTHLLAG--AALHIVPSER 419 Query: 270 KHQVNVTALVPPAVSLWLQALIEG--ESRAQL--ASLKLLQVGGARLSATLAARIPAEIG 325 K+ ++ + + L G E Q+ S +++ GG L +I Sbjct: 420 KYDLDALNDYCNQEGITISYLPTGAAEQFMQMDNQSFRVVITGGDVLK-----KIERNGT 474 Query: 326 CQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMT 385 +L +G E + T + G P+ + + D P G G L Sbjct: 475 YKLYNGYGPTECTIMVTMFEVDKPYANIPIGKPI-DRTRILILDEALALQPIGVAGELFI 533 Query: 386 RGPYTFRGYYKSPQHNASAF-----DANGFYCSGDLISIDPEGYITVQGREKDQINRGGE 440 G RGY P+ A F Y +GD P+G I GR + + G Sbjct: 534 VGEGLGRGYLNRPELTAEKFIVHPQTGERMYRTGDRARFLPDGNIEFLGRLDNLVKIRGY 593 Query: 441 KIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKEPLRAVQVRRFLREQGIAE 500 +I EIE L+ HP + +++ E + Y V E + ++R +L + + Sbjct: 594 RIEPGEIEPFLMNHPLIELTTVLAKEQADGRKYLVGYYVAPEEIPHGELREWLGND-LPD 652 Query: 501 FKLPDRVECVDSLPLTAVGKVDKKQL 526 + +P + + PLTA GKVD++ L Sbjct: 653 YMIPTYFVHMKAFPLTANGKVDRRAL 678 >6NJ0-A nrPDB Length = 451 Score = 77.8 bits (190), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 116/506 (22%), Positives = 206/506 (40%), Gaps = 78/506 (15%) Query: 33 RHAASDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFA 92 R ++IA+ + QL++REL D LA QG+ G +++ N + + + A Sbjct: 12 RQVRGETIALRLNDEQLNWRELCARVDELASGFAVQGVVEGSGVMLRAWNTPQTLLAWLA 71 Query: 93 LLKLG--VAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIR 150 LL+ G V PV E ++ AL+ G++ + H Sbjct: 72 LLQCGARVLPVNPQLPQPLLEELLPNLTLQFALVP--------DGENTFPALTSLH---- 119 Query: 151 VVQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYS 210 +QL+ G H AT P + L+ G+TG PK T+ + S Sbjct: 120 -IQLVE--GAH-------------AATWQPT-RLCSMTLTSGSTGLPKAAVHTYQAHLAS 162 Query: 211 VRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIEK 270 + + + F +L ++P H +S G + +L G + D +E+ Sbjct: 163 AQGVLSLIPFGDHDDWLLSLPLFH---VSGQGIMWRWLYAGARMTVRDKQP------LEQ 213 Query: 271 HQVNVT--ALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIGCQL 328 T +LVP LW + L+ S SLK + +GGA + L + E G + Sbjct: 214 MLAGCTHASLVP--TQLW-RLLVNRSS----VSLKAVLLGGAAIPVELTEQ-AREQGIRC 265 Query: 329 QQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEV----GRLM 384 +G+ E +C + +AD G+PLP EV + Sbjct: 266 FCGYGLTEF------------------ASTVCAKEADGLADV-GSPLPGREVKIVNNEVW 306 Query: 385 TRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAA 444 R GY+++ Q S + G+Y + D + G +T+ GR + GGE I Sbjct: 307 LRAASMAEGYWRNGQL-VSLVNDEGWYATRDRGEMH-NGKLTIVGRLDNLFFSGGEGIQP 364 Query: 445 EEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKEPLRAVQVRRFLREQGIAEFKLP 504 EE+E ++ HPAV+ +V + D+ G + A V++ +V + +++++ +A F+ P Sbjct: 365 EEVERVIAAHPAVLQVFIVPVADKEFGHRPVA--VMEYDHESVDLSEWVKDK-LARFQQP 421 Query: 505 DRVECVDSLPLTAVGKVDKKQLRQWL 530 R + K+ ++ L++W+ Sbjct: 422 VRWLTLPPELKNGGIKISRQALKEWV 447 >3FCE-A nrPDB Length = 512 Score = 75.9 bits (185), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 121/517 (23%), Positives = 201/517 (38%), Gaps = 62/517 (11%) Query: 38 DSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLG 97 D A + + +++Y++L + +D LA + + +V E+ I F +K G Sbjct: 16 DQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHMQPEMIINFLGCVKAG 75 Query: 98 VAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLND 157 A + S + A LL++ +R+V Sbjct: 76 HAYIPVDLSIPADRVQRIAENSGAKLLLS------------ATAVTVTDLPVRIVS---- 119 Query: 158 SGEHNLQDAI-NHPAEDFTATPSP-----ADEVAYFQLSGGTTGTPKLIPRTHNDYYYSV 211 E NL+D H TP+P DE Y + G+TG PK + T+N Sbjct: 120 --EDNLKDIFFTHKGN----TPNPEHAVKGDENFYIIYTSGSTGNPKGVQITYNCLVSFT 173 Query: 212 RRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVV-----LAADPSATLCFP 266 + +VE F QT + A ++ +S + GGT+ + A P F Sbjct: 174 KWAVE--DFNLQTGQVFLNQAPFSFDLSVMDIYPSLVTGGTLWAIDKDMIARPKD--LFA 229 Query: 267 LIEKHQVNVTALVPPAVSLWLQALIEGE-SRAQLASLKLLQVGGARLSATLAARIPAEI- 324 +E+ + V P S L+E S + L ++K G L +A ++ Sbjct: 230 SLEQSDIQVWTSTP---SFAEMCLMEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFP 286 Query: 325 GCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPM--CPDD-EVWVADAEGNPLPQGEVG 381 + +G E V T + + E + + P+ C D + + +G P GE G Sbjct: 287 KATIMNTYGPTEATVAVTGIHVTEEVLDQYKSLPVGYCKSDCRLLIMKEDGTIAPDGEKG 346 Query: 382 RLMTRGPYTFRGYYKSPQHNASAF---DANGFYCSGDLISIDPEGYITVQGREKDQINRG 438 ++ GP GY SP+ AF D Y +GD ++ G + GR QI Sbjct: 347 EIVIVGPSVSVGYLGSPELTEKAFTMIDGERAYKTGDAGYVE-NGLLFYNGRLDFQIKLH 405 Query: 439 GEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVV---------KEPLRAVQV 489 G ++ EEIE+ L V A +V ++ GEK L V KE + Sbjct: 406 GYRMELEEIEHHLRACSYVEGAVIVPIKK---GEKYDYLLAVVVPGEHSFEKEFKLTSAI 462 Query: 490 RRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQL 526 ++ L E+ + + +P + S+P+T GKVD+K+L Sbjct: 463 KKELNER-LPNYMIPRKFMYQSSIPMTPNGKVDRKKL 498 >3E7W-A nrPDB Length = 511 Score = 74.3 bits (181), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 108/518 (20%), Positives = 215/518 (41%), Gaps = 67/518 (12%) Query: 47 RQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVA-ELYITFFALLKLGVAPVLALF 105 + L+Y+EL + +D A +++++ ++ ++ G++ + ++F +K G P + + Sbjct: 25 QSLTYQELWEQSDRAAAAIQKRISGEKKSPILVYGHMEPHMIVSFLGSVKAG-HPYIPV- 82 Query: 106 SHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQD 165 +L+ + +I + + + + + ++ + ++ +LL + G QD Sbjct: 83 -----DLSIPSERIAKIIESSGAELLIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQD 137 Query: 166 AINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTR 225 E F Y + G+TG PK + + T Sbjct: 138 QWVKEHETF-----------YIIYTSGSTGNPKGV-------------QISAANLQSFTD 173 Query: 226 YLCA---IPAAHNYAMSSPGSLGVFL--------AGGT---VVLAADPSATLCFPLIEKH 271 ++CA + + +P S + + +GGT V A + F ++K Sbjct: 174 WICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKDAVNKPKVLFEELKKS 233 Query: 272 QVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAA----RIPAEIGCQ 327 +NV P V + L + G S+ L G L ++A R P + Sbjct: 234 GLNVWTSTPSFVQMCL--MDPGFSQDLLPHADTFMFCGEVLPVSVAKALLERFPK---AK 288 Query: 328 LQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMC---PDDEVWVADAEGNPLPQGEVGRLM 384 + +G E V T ++ + + I ++ P+ PD +++ D EG PLP+GE G ++ Sbjct: 289 IFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDEEGQPLPEGEKGEIV 348 Query: 385 TRGPYTFRGYYKSPQHNASAF---DANGFYCSGDLISIDPEGYITVQGREKDQINRGGEK 441 GP RGY P+ AF + Y +GD I +G I QGR QI G + Sbjct: 349 IAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQ-DGQIFCQGRLDFQIKLHGYR 407 Query: 442 IAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKEP--LRAVQVRRFLREQ--- 496 + EEIE + + V A ++ + E A +V +E + Q+ ++++ Sbjct: 408 MELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHEFEKEFQLTSAIKKELAA 467 Query: 497 GIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLASRA 534 + + +P + D + +TA GK+D+K++ + + R+ Sbjct: 468 SLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLVRS 505 >5WMM-A nrPDB Length = 926 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 111/463 (23%), Positives = 177/463 (38%), Gaps = 65/463 (14%) Query: 39 SIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGV 98 ++ DGE +Y EL++ A+ +A L +G+ + + L LK G Sbjct: 72 ALVAADGEESWTYGELDRWANRIAHHLHARGVGRQHRVALVMERSPLLVAAVLGTLKAGA 131 Query: 99 APVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDS 158 V + R+ ++ + ++PAL+I +R ++ L + T R + + Sbjct: 132 CYVPVEPTWPRARIDLVLADLDPALVIDERL-----AEEDLTGYPT-----RPLDTADVG 181 Query: 159 GEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEIC 218 GEH +AY + G+TGTPK + +H + + +++ C Sbjct: 182 GEH----------------------LAYLMYTSGSTGTPKGVEVSHRNV---LSLALDPC 216 Query: 219 QF-TQQTRYLCAIPA---AHNYAMSSPGSLGVFLAGGTVVLAAD---PSATLCFPLIEKH 271 R L P A Y M P L GG V+A +A L + E+ Sbjct: 217 WADADHQRVLVHAPPTFDASTYEMWVP-----LLHGGAAVVAPPGKLDAARLATLIAER- 270 Query: 272 QVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIGC-QLQQ 330 VTAL PA L LI ++ + GG LS R+ + G + Sbjct: 271 --GVTALWLPAG---LFDLITQHHPKSFVQVREVWAGGDVLSPAAVRRLVRDDGTLTVVN 325 Query: 331 VFGMAEGLVNYTRLDDSAE---KIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMTRG 387 +G E R SA K G PM ++ D +PQG +G L G Sbjct: 326 GYGPTETTTFAARYRMSAPARCKDPLPIGEPMA-GSRLYALDDRLRQVPQGVIGELYVGG 384 Query: 388 PYTFRGYYKSPQHNASAFDANGF-------YCSGDLISIDPEGYITVQGREKDQINRGGE 440 RGY P + F A+ F Y +GDL+ + +G + GR +Q+ G Sbjct: 385 DGVARGYANHPPLTSERFVADPFGRPGERMYRTGDLVRWNHDGQLEFLGRVDEQVKIRGF 444 Query: 441 KIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKEP 483 ++ EI L + V A +V D L + AY+V + P Sbjct: 445 RVEPGEIRAALRKRDGVAQAVVVPRTDRLGERRLVAYVVPEVP 487 >5U29-A nrPDB Length = 694 Score = 71.2 bits (173), Expect = 9e-13, Method: Compositional matrix adjust. Identities = 108/528 (20%), Positives = 205/528 (38%), Gaps = 52/528 (9%) Query: 47 RQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGV--APVLAL 104 R++SY EL Q +A L+ G+K G+ + L + F A ++G + V A Sbjct: 147 REVSYEELMQETCRVANVLKSYGVKKGDAVSIYLPMTWQAAAAFLACARIGAIHSAVFAG 206 Query: 105 FSHQ--RSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHN 162 FS + R +N ++ R + ++ + + + V +L +G Sbjct: 207 FSAESLRDRVNDCECKVLITTDEGRRGGKTIATKQIVDAALQQCPLVENVLVLRRTGNKV 266 Query: 163 LQDAINHPAEDFTATPSPA---------DEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRR 213 D PA ++ + + G+TG PK + + Y Sbjct: 267 PMTEGRDKWWDEECAKMPAYCPCERMASEDPLFILYTSGSTGKPKGVVHSTAGYLLGTAL 326 Query: 214 SVE-ICQFTQQTRYLCAIP----AAHNYAMSSPGSLGVFLAGGTVVLAADP---SATLCF 265 +++ + R+ C H+Y + P + G+ T V + P + + + Sbjct: 327 TLKYVFDAHPDDRFACMADIGWITGHSYIIYGPLANGI----TTAVFESTPVYPTPSRYW 382 Query: 266 PLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSAT---LAARIPA 322 ++K + P A+ L + + L+SL++L G ++ Sbjct: 383 DFVDKWKATQLYTAPTAIRLLRRMGEDHVKNHDLSSLRVLGSVGEPINPEAWHWYNDFAG 442 Query: 323 EIGCQLQQVFGMAE-GLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEV- 380 + C + + M E G ++ L + + +P D + G L +V Sbjct: 443 KNQCAIVDTYWMTETGSISIAPLPGAISTKPGSATFPFFGMDVDIIDPQTGQVLEGNDVE 502 Query: 381 GRLMTRGPY--TFRGYYKSPQHNASAF--DANGFYCSGDLISIDPEGYITVQGREKDQIN 436 G L+ R P+ R Y+ + + G++ GD + D +GY+ ++GR D IN Sbjct: 503 GVLVARRPWPSIARTVYRDHKRYLETYMKPYPGYFFFGDGAARDYDGYMWIKGRVDDVIN 562 Query: 437 RGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKEPLR----------- 485 G +++ E+E+ L+ H V A+V D+L G+ A++ +K Sbjct: 563 VSGHRLSTAEVESALILHKGVAETAVVGCADDLTGQAVYAFVTMKPEFDLKATKEADLSK 622 Query: 486 --AVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLA 531 A+QVR+ I F P ++ V LP T GK+ ++ LR+ +A Sbjct: 623 ELAIQVRKV-----IGPFAAPKKIYLVSDLPKTRSGKIMRRVLRKIVA 665 >3PBK-A nrPDB Length = 583 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 113/540 (20%), Positives = 213/540 (39%), Gaps = 84/540 (15%) Query: 46 ERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALF 105 E QL Y+ L A+ A L +K G+ + +E FFA G+ V Sbjct: 46 EDQLEYQTLKARAEAGAKRLLSLNLKKGDRVALIAETSSEFVEAFFACQYAGLVAVPLAI 105 Query: 106 SHQRSELNAYASQIEPALLIADRQHALFSGDDFL---NTFVTEHSSIRVVQLLNDSGEHN 162 + ++++++++ LL + + A+ +GD++L N ++ + V+ H Sbjct: 106 PMGVGQRDSWSAKLQ-GLLASCQPAAIITGDEWLPLVNAATHDNPELHVLS-------HA 157 Query: 163 LQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRR-SVEICQFT 221 A+ P D +++AY Q + G+T P+ + TH + ++R S + + Sbjct: 158 WFKAL--PEADVALQRPVPNDIAYLQYTSGSTRFPRGVIITHREVMANLRAISHDGIKLR 215 Query: 222 QQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLCF--------PLIEKHQV 273 R + +P H+ G +G L L+ D T F LI K++ Sbjct: 216 PGDRCVSWLPFYHDM-----GLVGFLLTPVATQLSVDYLRTQDFAMRPLQWLKLISKNRG 270 Query: 274 NVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIGCQLQQVF- 332 V+ P L + R L L + R++ A I AE Q + F Sbjct: 271 TVSVAPPFGYEL-------CQRRVNEKDLAELDLSCWRVAGIGAEPISAEQLHQFAECFR 323 Query: 333 -------------GMAEGLVNYTRLDDSA--------EKIIHTQGYPMCPDDE------- 364 G+AE + + D+++ I+ QG + P E Sbjct: 324 QVNFDNKTFMPCYGLAENALAVSFSDEASGVVVNEVDRDILEYQGKAVAPGAETRAVSTF 383 Query: 365 -----------VWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCS 413 + + + G P+ + VG + GP GY+ Q + A G+ + Sbjct: 384 VNCGKALPEHGIEIRNEAGMPVAERVVGHICISGPSLMSGYFGD-QVSQDEIAATGWLDT 442 Query: 414 GDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYA---ALVSMEDELM 470 GDL + +GY+ V GR KD I G I ++IE + + P + A V+ +++++ Sbjct: 443 GDLGYL-LDGYLYVTGRIKDLIIIRGRNIWPQDIEYIAEQEPEIHSGDAIAFVTAQEKII 501 Query: 471 GEKSCAYLVVKEPLRAVQVRRFLREQGIAEFKLPDRVECV--DSLPLTAVGKVDKKQLRQ 528 + C + + R Q+ L + +EF + ++ + S+P T+ GK + + ++ Sbjct: 502 LQIQCR---ISDEERRGQLIHALAARIQSEFGVTAAIDLLPPHSIPRTSSGKPARAEAKK 558 >5JNF-C nrPDB Length = 587 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 91/410 (22%), Positives = 154/410 (37%), Gaps = 61/410 (14%) Query: 38 DSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLG 97 D +AV+D + L+Y++LN+ A+ LA LR +G+KP + + L ++ ++ A++K G Sbjct: 220 DHVAVVDRGQSLTYKQLNERANQLAHHLRGKGVKPDDQVAIMLDKSLDMIVSILAVMKAG 279 Query: 98 VA--PVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLL 155 A P+ + +R A ++AD A+ L + E + ++ Sbjct: 280 GAYVPIDPDYPGERI-----------AYMLADSSAAI-----LLTNALHEEKANGACDII 323 Query: 156 N----DSGEHNLQD--AINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYY 209 + DS N + +N P D++ Y + G+TG K + H++ Sbjct: 324 DVHDPDSYSENTNNLPHVNRP-----------DDLVYVMYTSGSTGLAKGVMIEHHNL-- 370 Query: 210 SVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIE 269 V C++ + Y PA SS G L T +LA +A P Sbjct: 371 -----VNFCEWYRP--YFGVTPADKALVYSSFSFDGSALDIFTHLLAG--AALHIVPSER 421 Query: 270 KHQVNVTALVPPAVSLWLQALIEG--ESRAQL--ASLKLLQVGGARLSATLAARIPAEIG 325 K+ ++ + + L G E Q+ S +++ GG L +I Sbjct: 422 KYDLDALNDYCNQEGITISYLPTGAAEQFMQMDNQSFRVVITGGDVLK-----KIERNGT 476 Query: 326 CQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMT 385 +L +G E + T + G P+ + + D P G G L Sbjct: 477 YKLYNGYGPTECTIMVTMFEVDKPYANIPIGKPI-DRTRILILDEALALQPIGVAGELFI 535 Query: 386 RGPYTFRGYYKSPQHNASAF-----DANGFYCSGDLISIDPEGYITVQGR 430 G RGY P+ A F Y +GD P+G I GR Sbjct: 536 VGEGLGRGYLNRPELTAEKFIVHPQTGERMYRTGDRARFLPDGNIEFLGR 585 >3LNV-A nrPDB Length = 590 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 94/458 (20%), Positives = 175/458 (38%), Gaps = 62/458 (13%) Query: 46 ERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALF 105 E ++Y +L+Q A +A +L+ +G KPG+ L+ L F L G V ++ Sbjct: 38 EETMTYEQLDQHAKAIAATLQAEGAKPGDRVLLLFAPGLPLIQAFLGCLYAGCIAV-PIY 96 Query: 106 SHQRSELNAYASQI----EPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEH 161 + +L A +I +P +++ H D LNT +++ + +S E Sbjct: 97 PPAQEKLLDKAQRIVTNSKPVIVLMIADHIKKFTADELNT---NPKFLKIPAIALESIEL 153 Query: 162 NLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFT 221 N + + T ++++A+ Q + G+T PK + +H++ ++ + Sbjct: 154 NRSSS-------WQPTSIKSNDIAFLQYTSGSTMHPKGVMVSHHNLLDNLNKIFTSFHMN 206 Query: 222 QQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLCFPL-----IEKHQVNVT 276 +T +P H+ M G + + GG + P + L PL I K++ ++ Sbjct: 207 DETIIFSWLPPHHD--MGLIGCILTPIYGGIQAIMMSPFSFLQNPLSWLKHITKYKATIS 264 Query: 277 ALVPPAVSLWLQALIEGESRAQLASLKLLQVGGAR--LSATLAARIPA--EIGCQLQQVF 332 A ++ + E + S + GA T+ A E G + + + Sbjct: 265 GSPNFAYDYCVKRIREEKKEGLDLSSWVTAFNGAEPVREETMEHFYQAFKEFGFRKEAFY 324 Query: 333 ---GMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVAD----------AEGNPLPQ-- 377 G+AE + T + T D V AD + GNP+ + Sbjct: 325 PCYGLAEATLLVTGGTPGSSYKTLTLAKEQFQDHRVHFADDNSPGSYKLVSSGNPIQEVK 384 Query: 378 ------------GEVGRLMTRGPYTFRGYYKSPQHNASAF-------DANGFYC-SGDLI 417 +VG + + +GY+ P+ AF + + Y +GDL Sbjct: 385 IIDPDTLIPCDFDQVGEIWVQSNSVAKGYWNQPEETRHAFAGKIKDDERSAIYLRTGDLG 444 Query: 418 SIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHP 455 + E + V GR KD I G+ ++IE L+ P Sbjct: 445 FLH-ENELYVTGRIKDLIIIYGKNHYPQDIEFSLMHSP 481 >4WD1-A nrPDB Length = 658 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 45/175 (25%), Positives = 76/175 (43%), Gaps = 18/175 (10%) Query: 369 DAEGNPLPQGEVGRL-----MTRGPYTFRGYYKSPQHNASAFDA-NGFYCSGDLISIDPE 422 D G+PL EVG L M P F +++ S FD G + GD I++ Sbjct: 457 DPSGDPL-TDEVGELVVTNPMPSMPIRFWNDPDGSRYHDSYFDTYPGVWRHGDWITLTSR 515 Query: 423 GYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKE 482 G + + GR +NR G ++ + +I + R P + + ++ +E + G V Sbjct: 516 GSVVIHGRSDSTLNRQGVRMGSADIYEAVERLPEIRESLVIGIE-QPDGGYWMPLFVHLA 574 Query: 483 PLRAV------QVRRFLREQGIAEFKLPDRVECVDSLPLTAVGK---VDKKQLRQ 528 P + +++R +R ++ +PD V V +P T GK V K+L Q Sbjct: 575 PGATLDDALLDRIKRTIRVN-LSPRHVPDEVIEVPGIPHTLTGKRIEVPVKRLLQ 628 >4GR4-A nrPDB Length = 469 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 92/413 (22%), Positives = 145/413 (35%), Gaps = 51/413 (12%) Query: 36 ASDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLK 95 A D++A++ +L+Y LN+ A+ LA L G+ PG V L ++ + A+LK Sbjct: 88 APDAVALLHEADELTYGALNERANRLAHRLVGLGVAPGTLVGVHLERGFDMVVALLAVLK 147 Query: 96 LGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLL 155 G + L LL+ R L+ +T +++ V Sbjct: 148 AGGGYTMLDPQFPVERLALSLEDTGAPLLVTSRP---------LSGRLTGTTTLYVED-- 196 Query: 156 NDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSV 215 + A + PA + P D VA + G+TG PK + H Sbjct: 197 --------EAASDAPAGNLATGVGPED-VACVMFTSGSTGRPKGVMSPHR-ALTGTYLGQ 246 Query: 216 EICQFTQQTRYLCAIPAAHN-YAMSSPGSLGVFLAGGTVVLAA--DPSATLCFPLIEKHQ 272 + F +L P + + + + G L G VL + +P L+ +H Sbjct: 247 DYAGFGPDEVFLQCSPVSWDAFGLE---LFGALLFGARCVLQSGQNPDPLEIGELVARHG 303 Query: 273 VNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARI----PAEIGCQL 328 V + L S L + E ++ GG S A+ PA +L Sbjct: 304 VTMLQL-----SASLFNFLVDEVPEAFEGVRYAITGGEPASVPHVAKARRDHPA---LRL 355 Query: 329 QQVFGMAEGLVNYTRLDDSAEKIIHTQ---GYPMCPDDEVWVADAEGNPLPQGEVGRLMT 385 +G AE + T A + T G P+ +V D + P G +G L Sbjct: 356 GNGYGPAESMGFTTHHAVVAGDLSGTALPIGVPLA-GKRAYVLDDDLKPAANGALGELYV 414 Query: 386 RGPYTFRGYYKSPQHNASAFDANGF--------YCSGDLISIDPEGYITVQGR 430 G GY P A F A+ F Y +GDL +G + GR Sbjct: 415 AGAGLAHGYVSRPALTAERFVADPFAGPGGERMYRTGDLARRRADGVLEYVGR 467 >4RVO-A nrPDB Length = 436 Score = 36.2 bits (82), Expect = 0.033, Method: Compositional matrix adjust. Identities = 75/350 (21%), Positives = 128/350 (36%), Gaps = 22/350 (6%) Query: 190 SGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPG---SLGV 246 S GTTG P +I + +D S V C + R + Y M + G G Sbjct: 94 SSGTTGNPTVIVHSQHDLD-SWANLVARCLYMVGIRKTDVFQNSSGYGMFTGGLGFQYGA 152 Query: 247 FLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQ 306 G V AA ++ I + +P + E + +LK L Sbjct: 153 ERLGCLTVPAAAGNSKRQIKFISDFKTTALHAIPSYAIRLAEVFQEEGIDPRETTLKTLV 212 Query: 307 VGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVW 366 +G + +I + + FGM E + + +H + C V Sbjct: 213 IGAEPHTDEQRRKIERMLNVKAYNSFGMTEMNGPGVAFECQEQNGMHF--WEDCY--LVE 268 Query: 367 VADAE-GNPLPQGEVGRL-MTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGY 424 + D E G P+P+GE+G L +T + + + C + ID Sbjct: 269 IIDPETGEPVPEGEIGELVLTTLDREMMPLIRYRTRDLTRILPGKCPCGRTHLRID---- 324 Query: 425 ITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSME-----DELMGEKSCAYLV 479 ++GR D G I ++E +L++ P + L+++E DE++ E + L Sbjct: 325 -RIKGRSDDMFIIKGVNIFPMQVEKILVQFPELGSNYLITLETVNNQDEMIVEVELSDLS 383 Query: 480 VKEPLRAVQVRRFLREQGIAEFKLPDRVECVD--SLPLTAVGKVDKKQLR 527 + ++RR + Q E + +V+ V SLP + V K LR Sbjct: 384 TDNYIELEKIRRDIIRQLKDEILVTPKVKLVKKGSLPQSEGKAVRVKDLR 433 >4IZO-A nrPDB Length = 419 Score = 35.0 bits (79), Expect = 0.073, Method: Compositional matrix adjust. Identities = 17/48 (35%), Positives = 26/48 (54%), Gaps = 1/48 (2%) Query: 184 VAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIP 231 V +F L G+ ++ PR HN +Y+V + E QF QQ R + +P Sbjct: 285 VEFFVLEDGSLVANEMAPRPHNSGHYTV-DACETSQFEQQVRAMTRLP 331 >4E4T-A nrPDB Length = 419 Score = 32.7 bits (73), Expect = 0.42, Method: Compositional matrix adjust. Identities = 16/48 (33%), Positives = 25/48 (52%), Gaps = 1/48 (2%) Query: 184 VAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIP 231 V +F L G+ ++ PR HN +Y+V + QF QQ R + +P Sbjct: 285 VEFFVLEDGSFVANEMAPRPHNSGHYTV-DACATSQFEQQVRAMTRMP 331 >2Y4N-A nrPDB Length = 437 Score = 32.0 bits (71), Expect = 0.76, Method: Compositional matrix adjust. Identities = 48/215 (22%), Positives = 88/215 (40%), Gaps = 20/215 (9%) Query: 180 PADEVAYFQLSGGTTGTPKLIPRTHND---YYYSVRRSVEICQFTQQTRYLCAIPAAHNY 236 P D ++ S GTTG P ++ T D + V RS+ R + ++ Y Sbjct: 88 PQDRISRIHASSGTTGKPTVVGYTAADIDTWANLVARSIRAA----GARRGDKVHVSYGY 143 Query: 237 AMSSPG---SLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEG 293 + + G G AG TV+ LI+ + ++ +V P+ L + IE Sbjct: 144 GLFTGGLGAHYGAERAGLTVIPFGGGQTEKQVQLIQDFRPDII-MVTPSYMLSIADEIER 202 Query: 294 ESRAQL-ASLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKII 352 + + +SL++ G + + I +G ++G++E + A + + Sbjct: 203 QGLDPVQSSLRIGIFGAEPWTNDMRVAIEQRMGIDAVDIYGLSEVMGPGV-----ASECV 257 Query: 353 HTQGYPMCPDDEVW--VADAE-GNPLPQGEVGRLM 384 T+ P +D + + D E G LP GE+G L+ Sbjct: 258 ETKDGPTIWEDHFYPEIIDPETGEVLPDGELGELV 292 >5EP0-A nrPDB Length = 396 Score = 31.6 bits (70), Expect = 1.0, Method: Compositional matrix adjust. Identities = 27/103 (26%), Positives = 45/103 (43%), Gaps = 5/103 (4%) Query: 82 NVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNT 141 +VA LY ++ L L V+ V E ++ I P L++ D + +G + L Sbjct: 15 SVAALYKSYLNPLGLNVSIV-----GTGKEALSFIQDIIPDLILLDLRLPDMTGMEVLER 69 Query: 142 FVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPADEV 184 EH ++ VV + +AI + A+DF P AD + Sbjct: 70 VRKEHGNVPVVIMTAHGSIDIAVEAIRYGAQDFLIKPCEADRL 112 >2ATV-A nrPDB Length = 196 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 26/92 (28%), Positives = 41/92 (44%), Gaps = 17/92 (18%) Query: 7 RWPEEFARRY--REKGYWQD-LPLTDILTRHAASDSIAVI--------DGERQLSYRELN 55 RW E F Y ++G +++ LPL +IL ++ +I D RQ+S E Sbjct: 97 RWGEGFVLVYDITDRGSFEEVLPLKNILDEIKKPKNVTLILVGNKADLDHSRQVSTEEGE 156 Query: 56 QAADNLACSLRRQGIKPGETALVQLGNVAELY 87 + A LAC+ GE GN+ E++ Sbjct: 157 KLATELACAFYECSACTGE------GNITEIF 182 >1UFR-A nrPDB Length = 181 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 17/58 (29%), Positives = 26/58 (44%) Query: 352 IHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANG 409 IHT+G P+ ++A+ EG +P G + + R T GY + FD G Sbjct: 39 IHTRGIPLAHRIARFIAEFEGKEVPVGVLDITLYRDDLTEIGYRPQVRETRIPFDLTG 96 >1EWN-A nrPDB Length = 219 Score = 28.9 bits (63), Expect = 5.2, Method: Compositional matrix adjust. Identities = 18/56 (32%), Positives = 24/56 (42%), Gaps = 3/56 (5%) Query: 457 VIYAALVSMEDELMGEKSCAYLVVKEPLRAVQVRRFLR---EQGIAEFKLPDRVEC 509 +IY M G+ +C L EPL ++ R LR +G A L DR C Sbjct: 81 IIYGMYFCMNISSQGDGACVLLRALEPLEGLETMRQLRSTLRKGTASRVLKDRELC 136 >6HIV-BC nrPDB Length = 523 Score = 28.9 bits (63), Expect = 5.3, Method: Compositional matrix adjust. Identities = 20/80 (25%), Positives = 40/80 (50%), Gaps = 5/80 (6%) Query: 50 SYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQR 109 ++ ++ + ++ LA L + G++PG+ L E ++ A K+G +LA+ H Sbjct: 91 AFADIRKNSEALAHGLLQTGLRPGQRVLAIQPCNCETFVLQLACAKIGA--LLAVVPHHN 148 Query: 110 ---SELNAYASQIEPALLIA 126 +L Y ++ +P LIA Sbjct: 149 ISADKLRFYLNEFQPHHLIA 168 Score = 28.5 bits (62), Expect = 7.7, Method: Compositional matrix adjust. Identities = 16/62 (25%), Positives = 25/62 (40%) Query: 370 AEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQG 429 A+ L G L +GP+ GYY + D GF + +D G +T+ G Sbjct: 460 ADARILAANTRGNLKLKGPHISAGYYNNAGLLTELVDERGFCSTSREAVMDERGQLTLHG 519 Query: 430 RE 431 + Sbjct: 520 TQ 521 >5D6N-A nrPDB Length = 508 Score = 28.9 bits (63), Expect = 6.4, Method: Compositional matrix adjust. Identities = 41/197 (20%), Positives = 78/197 (39%), Gaps = 18/197 (9%) Query: 47 RQLSYRELNQAADNLACSLRRQGI-KPGETALVQLGNVAELYITFFALLKLGVAPVLALF 105 R L++ + +A N A + R Q + +PG+ + + + FF L G V LF Sbjct: 76 RDLTWAQF--SARNRAVAARLQQVTQPGDRVAILCPQNLDYLVAFFGALYAGRIAV-PLF 132 Query: 106 SHQR----SELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEH 161 L+A P+ ++ + A + F T ++ R + D+ Sbjct: 133 DPSEPGHVGRLHAVLDNCHPSAILTTTEAA----EGVRKFFRTRPANQRPRVIAVDAVPD 188 Query: 162 NLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFT 221 ++ +P E T +AY Q + G+T P + TH + +V + +E + Sbjct: 189 DVASTWVNPDEPDETT------IAYLQYTSGSTRIPTGVQITHLNLATNVVQVIEALEGE 242 Query: 222 QQTRYLCAIPAAHNYAM 238 + R L +P H+ + Sbjct: 243 EGDRGLSWLPFFHDMGL 259 >5EY8-A nrPDB Length = 630 Score = 28.9 bits (63), Expect = 6.5, Method: Compositional matrix adjust. Identities = 41/197 (20%), Positives = 78/197 (39%), Gaps = 18/197 (9%) Query: 47 RQLSYRELNQAADNLACSLRRQGI-KPGETALVQLGNVAELYITFFALLKLGVAPVLALF 105 R L++ + +A N A + R Q + +PG+ + + + FF L G V LF Sbjct: 52 RDLTWAQF--SARNRAVAARLQQVTQPGDRVAILCPQNLDYLVAFFGALYAGRIAV-PLF 108 Query: 106 SHQR----SELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEH 161 L+A P+ ++ + A + F T ++ R + D+ Sbjct: 109 DPSEPGHVGRLHAVLDNCHPSAILTTTEAA----EGVRKFFRTRPANQRPRVIAVDAVPD 164 Query: 162 NLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFT 221 ++ +P E T +AY Q + G+T P + TH + +V + +E + Sbjct: 165 DVASTWVNPDEPDETT------IAYLQYTSGSTRIPTGVQITHLNLATNVVQVIEALEGE 218 Query: 222 QQTRYLCAIPAAHNYAM 238 + R L +P H+ + Sbjct: 219 EGDRGLSWLPFFHDMGL 235 >4WKO-A nrPDB Length = 245 Score = 28.5 bits (62), Expect = 8.2, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 24/46 (52%) Query: 96 LGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNT 141 LG P A+F LNA A +I IA ++ + SGD F+++ Sbjct: 126 LGFIPESAIFIETSGSLNALAKKIANEQHIALKEGVIASGDQFVHS 171 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3RG2-A nrPDB 670 0.0 3O84-A nrPDB 557 e-159 1MDF-A nrPDB 529 e-150 3A9U-A nrPDB 443 e-125 5BSW-A nrPDB 440 e-124 4M46-A nrPDB 438 e-123 3TSY-A nrPDB 434 e-122 5DWV-A nrPDB 430 e-121 4EAT-A nrPDB 422 e-118 4WV3-A nrPDB 420 e-118 2D1S-A nrPDB 419 e-117 5BUS-A nrPDB 416 e-117 4FUQ-A nrPDB 416 e-116 3R44-A nrPDB 411 e-115 2V7B-A nrPDB 408 e-114 3ETC-A nrPDB 405 e-113 5IE2-A nrPDB 401 e-112 3IVR-A nrPDB 395 e-110 5U29-A nrPDB 392 e-109 5JRH-A nrPDB 391 e-109 1RY2-A nrPDB 390 e-109 3GPC-A nrPDB 382 e-106 5ES8-A nrPDB 380 e-106 5ES6-A nrPDB 379 e-105 3FCE-A nrPDB 374 e-104 4LGC-A nrPDB 371 e-103 3E7W-A nrPDB 367 e-102 3DLP-X nrPDB 364 e-101 3IPL-A nrPDB 359 2e-99 1V25-A nrPDB 347 6e-96 4GR5-A nrPDB 345 2e-95 3L8C-A nrPDB 341 6e-94 4R0M-B nrPDB 320 9e-88 3PBK-A nrPDB 318 3e-87 5WMM-A nrPDB 315 3e-86 3LNV-A nrPDB 305 2e-83 6NJ0-A nrPDB 302 2e-82 5JNF-C nrPDB 288 5e-78 4WD1-A nrPDB 230 1e-60 Sequences not found previously or not previously below threshold: 4GR4-A nrPDB 251 6e-67 5EY8-A nrPDB 224 9e-59 5EY9-A nrPDB 201 5e-52 5HM3-A nrPDB 198 8e-51 5D6N-A nrPDB 192 3e-49 3E53-A nrPDB 161 6e-40 4RVO-A nrPDB 116 2e-26 2Y4O-A nrPDB 99 4e-21 2Y4N-A nrPDB 99 6e-21 6HIV-BC nrPDB 94 2e-19 2OGE-A nrPDB 35 0.077 5VLB-A nrPDB 35 0.078 2C81-A nrPDB 35 0.084 3M6I-A nrPDB 35 0.11 5YHV-A nrPDB 33 0.27 3DR4-A nrPDB 32 0.59 1NL3-A nrPDB 32 0.96 3J15-B nrPDB 30 2.6 5FXF-A nrPDB 30 2.6 3KGX-A nrPDB 30 2.7 4YPL-A nrPDB 28 9.3 >3RG2-A nrPDB Length = 617 Score = 670 bits (1728), Expect = 0.0, Method: Composition-based stats. Identities = 536/536 (100%), Positives = 536/536 (100%) Query: 1 MSIPFTRWPEEFARRYREKGYWQDLPLTDILTRHAASDSIAVIDGERQLSYRELNQAADN 60 MSIPFTRWPEEFARRYREKGYWQDLPLTDILTRHAASDSIAVIDGERQLSYRELNQAADN Sbjct: 3 MSIPFTRWPEEFARRYREKGYWQDLPLTDILTRHAASDSIAVIDGERQLSYRELNQAADN 62 Query: 61 LACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIE 120 LACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIE Sbjct: 63 LACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIE 122 Query: 121 PALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSP 180 PALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSP Sbjct: 123 PALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSP 182 Query: 181 ADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSS 240 ADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSS Sbjct: 183 ADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSS 242 Query: 241 PGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLA 300 PGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLA Sbjct: 243 PGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLA 302 Query: 301 SLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMC 360 SLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMC Sbjct: 303 SLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMC 362 Query: 361 PDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISID 420 PDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISID Sbjct: 363 PDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISID 422 Query: 421 PEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVV 480 PEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVV Sbjct: 423 PEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVV 482 Query: 481 KEPLRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLASRASA 536 KEPLRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLASRASA Sbjct: 483 KEPLRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLASRASA 538 >3O84-A nrPDB Length = 544 Score = 557 bits (1436), Expect = e-159, Method: Composition-based stats. Identities = 300/539 (55%), Positives = 388/539 (71%), Gaps = 7/539 (1%) Query: 3 IPFTRWPEEFARRYREKGYWQDLPLTDILTRHAA--SDSIAVIDGERQLSYRELNQAADN 60 I F RW E A+ YR KGYW D PLT ILT S+A+I GERQLSY EL++ + N Sbjct: 8 IEFVRWSPERAQHYRNKGYWIDQPLTRILTVGVQSHPHSLAIICGERQLSYIELDRLSTN 67 Query: 61 LACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIE 120 LA L +G+ G+TALVQL NVAE YI FFALLK GV + AL+SH++ ELNA+ QI+ Sbjct: 68 LATRLAEKGLGKGDTALVQLPNVAEFYIVFFALLKAGVVVLNALYSHRQYELNAFIKQIQ 127 Query: 121 PALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLN-DSGEHNLQDAINHPAEDF-TATP 178 P LLI RQH +FS + F+++ + S ++ +LN + + L D I PAE F + Sbjct: 128 PKLLIGSRQHEVFSNNQFIDSLHDVNLSPEIILMLNHQATDFGLLDWIETPAETFVDFSS 187 Query: 179 SPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAM 238 +PADEVA+FQLSGG+TGTPKLIPRTHNDY YSVR S EIC TR LCA+PA HN+ + Sbjct: 188 TPADEVAFFQLSGGSTGTPKLIPRTHNDYDYSVRASAEICGLNSNTRLLCALPAPHNFML 247 Query: 239 SSPGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQ 298 SSPG+LGV AGG VV+A +P CF +I++HQVN+ +LVP AV +WL+ + + Q Sbjct: 248 SSPGALGVLHAGGCVVMAPNPEPLNCFSIIQRHQVNMASLVPSAVIMWLEKA--AQYKDQ 305 Query: 299 LASLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYP 358 + SLKLLQVGGA +LA ++P + C+LQQVFGMAEGLVNYTRLDDS E+I TQG P Sbjct: 306 IQSLKLLQVGGASFPESLARQVPEVLNCKLQQVFGMAEGLVNYTRLDDSDEQIFTTQGRP 365 Query: 359 MCPDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLIS 418 + DDE+ + D + +P+GE+G L TRGPYTF GYY+SP+HN+ FD + +Y SGDL+ Sbjct: 366 ISSDDEIKIVDEQYREVPEGEIGMLATRGPYTFCGYYQSPEHNSQVFDEDNYYYSGDLVQ 425 Query: 419 IDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYL 478 P+G + V GR KDQINRGGEKIA+EEIE L+L HP V++AALV++ DE GEKSCA++ Sbjct: 426 RTPDGNLRVVGRIKDQINRGGEKIASEEIEKLILLHPEVMHAALVAIVDEQFGEKSCAFI 485 Query: 479 VVKEP-LRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLASRASA 536 V + P L+AV +RR L E GIA++KLPD+++ ++SLPLTAVGKVDKKQLR L + ++ Sbjct: 486 VSRNPELKAVVLRRHLMELGIAQYKLPDQIKLIESLPLTAVGKVDKKQLRSILNTSTTS 544 >1MDF-A nrPDB Length = 539 Score = 529 bits (1362), Expect = e-150, Method: Composition-based stats. Identities = 251/532 (47%), Positives = 340/532 (63%), Gaps = 7/532 (1%) Query: 5 FTRWPEEFARRYREKGYWQDLPLTDILTRHAA--SDSIAVIDGERQLSYRELNQAADNLA 62 FT WP+E A YR+ G W D+L AA D IA+ G SYREL+ AD LA Sbjct: 5 FTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAITCGNTHWSYRELDTRADRLA 64 Query: 63 CSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPA 122 ++ GI+ + +VQL N+ E + FAL +LG PV AL SH+ SE+ + E A Sbjct: 65 AGFQKLGIQQKDRVVVQLPNIKEFFEVIFALFRLGALPVFALPSHRSSEITYFCEFAEAA 124 Query: 123 LLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPAD 182 I ++ F ++ +++ + + ++ E + + E + Sbjct: 125 AYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEAEEFLPLE--DLHTEPVKLPEVKSS 182 Query: 183 EVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPG 242 +VA+ QLSGG+TG KLIPRTH+DY YS++RSVE+C T YL A+P AHNY +SSPG Sbjct: 183 DVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVCWLDHSTVYLAALPMAHNYPLSSPG 242 Query: 243 SLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLASL 302 LGV AGG VVL+ PS FPLIE+ +V +TALVPP +W+ A R L+SL Sbjct: 243 VLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTITALVPPLAMVWMDAA--SSRRDDLSSL 300 Query: 303 KLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPD 362 ++LQVGGA+ SA A R+ A GC LQQVFGMAEGLVNYTRLDD E I++TQG PM P Sbjct: 301 QVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAEGLVNYTRLDDPEEIIVNTQGKPMSPY 360 Query: 363 DEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPE 422 DE V D + GE G L+TRGPYT RGYYK+ +HNA++F +GFY +GD++ + + Sbjct: 361 DESRVWDDHDRDVKPGETGHLLTRGPYTIRGYYKAEEHNAASFTEDGFYRTGDIVRLTRD 420 Query: 423 GYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKE 482 GYI V+GR KDQINRGGEK+AAEE+EN LL HPAV AA+VSM D+ +GE+SC +++ ++ Sbjct: 421 GYIVVEGRAKDQINRGGEKVAAEEVENHLLAHPAVHDAAMVSMPDQFLGERSCVFIIPRD 480 Query: 483 P-LRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLASR 533 +A +++ FLRE+G+A +K+PDRVE V+S P T VGKV KK LR+ ++ + Sbjct: 481 EAPKAAELKAFLRERGLAAYKIPDRVEFVESFPQTGVGKVSKKALREAISEK 532 >3A9U-A nrPDB Length = 536 Score = 443 bits (1139), Expect = e-125, Method: Composition-based stats. Identities = 134/540 (24%), Positives = 240/540 (44%), Gaps = 26/540 (4%) Query: 10 EEFARRYREKGYW--QDLPLTDILTRHAASDSI--AVIDGERQ--LSYRELNQAADNLAC 63 EEF R + + ++LPL + + ++ S +I+G +Y ++ A +A Sbjct: 5 EEFIFRSKLPDIYIPKNLPLHSYVLENLSNHSSKPCLINGANGDVYTYADVELTARRVAS 64 Query: 64 SLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPAL 123 L + GI+ G+ ++ L + E + F G A +EL +A L Sbjct: 65 GLNKIGIQQGDVIMLFLPSSPEFVLAFLGASHRGAIITAANPFSTPAELAKHAKASRAKL 124 Query: 124 LIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPADE 183 LI + + + F E + G + + + D+ Sbjct: 125 LITQACYY-----EKVKDFARESDVKVMCVDSAPDGCLHFSELTQADENEAPQVDISPDD 179 Query: 184 VAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEI----CQFTQQTRYLCAIPAAHNYAMS 239 V S GTTG PK + TH SV + V+ F + LC +P H YA++ Sbjct: 180 VVALPYSSGTTGLPKGVMLTHKGLITSVAQQVDGDNPNLYFHSEDVILCVLPMFHIYALN 239 Query: 240 SPGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQL 299 S G+ + G +++ LIEK++V++ +VPP + ++ + L Sbjct: 240 SIMLCGLRV-GAPILIMPKFEIGSLLGLIEKYKVSIAPVVPPVMMSIAKS--PDLDKHDL 296 Query: 300 ASLKLLQVGGARLSATLAARIPAEI-GCQLQQVFGMAE-GLVNYTRLDDSAEKIIHTQGY 357 +SL++++ GGA L L + A+ +L Q +GM E G V L + E G Sbjct: 297 SSLRMIKSGGAPLGKELEDTVRAKFPQARLGQGYGMTEAGPVLAMCLAFAKEPFDIKPGA 356 Query: 358 --PMCPDDEVWVADAE-GNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSG 414 + + E+ + D E G LP+ + G + RG +GY P+ + D G+ +G Sbjct: 357 CGTVVRNAEMKIVDPETGASLPRNQPGEICIRGDQIMKGYLNDPEATSRTIDKEGWLHTG 416 Query: 415 DLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKS 474 D+ ID + + + R K+ I G ++A E+E LL+ HP + AA+V ++DE GE Sbjct: 417 DIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLIAHPEISDAAVVGLKDEDAGEVP 476 Query: 475 CAYLVVKEPLRA--VQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLAS 532 A++V E +A ++++++ +Q I +K RV ++++P GK+ +K L++ LA Sbjct: 477 VAFVVKSEKSQATEDEIKQYISKQVIF-YKRIKRVFFIEAIPKAPSGKILRKNLKEKLAG 535 >5BSW-A nrPDB Length = 541 Score = 440 bits (1131), Expect = e-124, Method: Composition-based stats. Identities = 133/544 (24%), Positives = 234/544 (43%), Gaps = 37/544 (6%) Query: 11 EFARRYREKGYWQ--DLPLTDILTRHAA--SDSIAVIDG--ERQLSYRELNQAADNLACS 64 + R + + LPL + + S +I+G ++ +Y ++ + +A Sbjct: 9 DIIFRSKLPDIYIPNHLPLHSYCFENISEFSSRPCLINGANKQIYTYADVELNSRKVAAG 68 Query: 65 LRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALL 124 L +QGI+P +T ++ L N E F LG +A +E+ A ++ Sbjct: 69 LHKQGIQPKDTIMILLPNSPEFVFAFIGASYLGAISTMANPLFTPAEVVKQAKASSAKII 128 Query: 125 IADRQH------ALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATP 178 + H F D + + +L + EH++ + P Sbjct: 129 VTQACHVNKVKDYAFENDVKIICIDSAPEGCLHFSVLTQANEHDIPEVEIQP-------- 180 Query: 179 SPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEI----CQFTQQTRYLCAIPAAH 234 D+V S GTTG PK + TH SV + V+ + LC +P H Sbjct: 181 ---DDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYIHSEDVMLCVLPLFH 237 Query: 235 NYAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGE 294 Y+++S G+ + G +++ LI++++V + VPP V ++ + + Sbjct: 238 IYSLNSVLLCGLRV-GAAILIMQKFDIVSFLELIQRYKVTIGPFVPPIVLAIAKSPMVDD 296 Query: 295 SRAQLASLKLLQVGGARLSATLAARIPAEI-GCQLQQVFGMAEGLVNYTRLDDSAEKIIH 353 L+S++ + G A L L + A+ +L Q +GM E L + E Sbjct: 297 --YDLSSVRTVMSGAAPLGKELEDTVRAKFPNAKLGQGYGMTEAGPLAMCLAFAKEPFEI 354 Query: 354 TQGY--PMCPDDEVWVADAE-GNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGF 410 G + + E+ + D + GN LP+ + G + RG +GY P+ A D G+ Sbjct: 355 KSGACGTVVRNAEMKIVDPKTGNSLPRNQSGEICIRGDQIMKGYLNDPEATARTIDKEGW 414 Query: 411 YCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELM 470 +GD+ ID + + + R K+ I G ++A E+E LLL HP + AA+V M+DE Sbjct: 415 LYTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLLNHPNISDAAVVPMKDEQA 474 Query: 471 GEKSCAYLVVK--EPLRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQ 528 GE A++V + +V+ F+ +Q I +K RV VD++P + GK+ +K LR Sbjct: 475 GEVPVAFVVRSNGSTITEDEVKDFISKQVIF-YKRIKRVFFVDAIPKSPSGKILRKDLRA 533 Query: 529 WLAS 532 LA+ Sbjct: 534 KLAA 537 >4M46-A nrPDB Length = 581 Score = 438 bits (1125), Expect = e-123, Method: Composition-based stats. Identities = 118/546 (21%), Positives = 219/546 (40%), Gaps = 41/546 (7%) Query: 9 PEEFARRYREKGYWQDLPLTDILTRHAA-SDSIAVIDG--ERQLSYRELNQAADNLACSL 65 P F Y + L + R+A +IA D E ++Y E + A LA ++ Sbjct: 45 PPPF---YPLEDGTAGEQLHKAMKRYAQVPGTIAFTDAHAEVNITYSEYFEMACRLAETM 101 Query: 66 RRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLI 125 +R G+ V N + ++ L +GV + EL S +P ++ Sbjct: 102 KRYGLGLQHHIAVCSENSLQFFMPVCGALFIGVGVAPTNDIYNERELYNSLSISQPTIVF 161 Query: 126 ADRQHALFSGDDFLNTFVTEHSSIRVVQLL-------NDSGEHNLQDAINHP----AEDF 174 ++ L + + ++Q + + G+ ++ I ++ Sbjct: 162 CSKRA--------LQKILGVQKKLPIIQKIVILDSREDYMGKQSMYSFIESHLPAGFNEY 213 Query: 175 TATPSPADE---VAYFQLSGGTTGTPKLIPRTHNDY---YYSVRRSVEICQFTQQTRYLC 228 P D A S G+TG PK + TH + + R V Q T L Sbjct: 214 DYIPDSFDRETATALIMNSSGSTGLPKGVELTHKNICVRFSHCRDPVFGNQIIPDTAILT 273 Query: 229 AIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQ 288 IP H + M + +LG G +VL L ++ +++ LVP S + + Sbjct: 274 VIPFHHGFGMFT--TLGYLTCGFRIVLMYRFEEELFLRSLQDYKIQSALLVPTLFSFFAK 331 Query: 289 ALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIGCQ-LQQVFGMAEGLVNYTRLDDS 347 + + + L++L + GGA L+ + + ++Q +G+ E + Sbjct: 332 STLVD--KYDLSNLHEIASGGAPLAKEVGEAVAKRFKLPGIRQGYGLTETTSAIIITPE- 388 Query: 348 AEKIIHTQGYPMCPDDEVWVAD-AEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFD 406 + G + P + D G L + G L +GP +GY +P+ ++ D Sbjct: 389 GDDKPGACGK-VVPFFSAKIVDLDTGKTLGVNQRGELCVKGPMIMKGYVNNPEATSALID 447 Query: 407 ANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSME 466 +G+ SGD+ D +G+ + R K I G ++ E+E++LL+HP + A + + Sbjct: 448 KDGWLHSGDIAYYDKDGHFFIVDRLKSLIKYKGYQVPPAELESILLQHPFIFDAGVAGIP 507 Query: 467 DELMGEKSCAYLVVKE--PLRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKK 524 D GE A +V++E + +V ++ Q A +L V+ VD +P GK+D + Sbjct: 508 DPDAGELPAAVVVLEEGKTMTEQEVMDYVAGQVTASKRLRGGVKFVDEVPKGLTGKIDAR 567 Query: 525 QLRQWL 530 ++R+ L Sbjct: 568 KIREIL 573 >3TSY-A nrPDB Length = 979 Score = 434 bits (1117), Expect = e-122, Method: Composition-based stats. Identities = 128/544 (23%), Positives = 241/544 (44%), Gaps = 28/544 (5%) Query: 11 EFARRYREKGYWQ--DLPLTDILTRHAASDSI--AVIDGERQ--LSYRELNQAADNLACS 64 + R + + L L D + ++ + + +I+G +Y +++ + +A + Sbjct: 45 DVIFRSKLPDIYIPNHLSLHDYIFQNISEFATKPCLINGPTGHVYTYSDVHVISRQIAAN 104 Query: 65 LRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALL 124 + G+ + ++ L N E ++F A G A +E+ A L+ Sbjct: 105 FHKLGVNQNDVVMLLLPNCPEFVLSFLAASFRGATATAANPFFTPAEIAKQAKASNTKLI 164 Query: 125 IA-----DRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPS 179 I D+ L + D + + ++ S+ + + E L + +E + Sbjct: 165 ITEARYVDKIKPLQNDDGVVIVCIDDNESVPIPEGCLRFTE--LTQSTTEASEVIDSVEI 222 Query: 180 PADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEI----CQFTQQTRYLCAIPAAHN 235 D+V S GTTG PK + TH SV + V+ F LC +P H Sbjct: 223 SPDDVVALPYSSGTTGLPKGVMLTHKGLVTSVAQQVDGENPNLYFHSDDVILCVLPMFHI 282 Query: 236 YAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGES 295 YA++S G+ + G +++ L LI++ +V V +VPP V ++ Sbjct: 283 YALNSIMLCGLRV-GAAILIMPKFEINLLLELIQRCKVTVAPMVPPIVLAIAKSSETE-- 339 Query: 296 RAQLASLKLLQVGGARLSATLAARIPAEI-GCQLQQVFGMAE-GLVNYTRLDDSAEKIIH 353 + L+S+++++ G A L L + A+ +L Q +GM E G V L + E Sbjct: 340 KYDLSSIRVVKSGAAPLGKELEDAVNAKFPNAKLGQGYGMTEAGPVLAMSLGFAKEPFPV 399 Query: 354 TQGY--PMCPDDEVWVADAE-GNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGF 410 G + + E+ + D + G+ L + + G + RG +GY +P A D +G+ Sbjct: 400 KSGACGTVVRNAEMKIVDPDTGDSLSRNQPGEICIRGHQIMKGYLNNPAATAETIDKDGW 459 Query: 411 YCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELM 470 +GD+ ID + + + R K+ I G ++A E+E LL+ HP + A+V+M++E Sbjct: 460 LHTGDIGLIDDDDELFIVDRLKELIKYKGFQVAPAELEALLIGHPDITDVAVVAMKEEAA 519 Query: 471 GEKSCAYLVVKE--PLRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQ 528 GE A++V + L V++F+ +Q + +K ++V +S+P GK+ +K LR Sbjct: 520 GEVPVAFVVKSKDSELSEDDVKQFVSKQVVF-YKRINKVFFTESIPKAPSGKILRKDLRA 578 Query: 529 WLAS 532 LA+ Sbjct: 579 KLAN 582 >5DWV-A nrPDB Length = 573 Score = 430 bits (1105), Expect = e-121, Method: Composition-based stats. Identities = 115/540 (21%), Positives = 217/540 (40%), Gaps = 38/540 (7%) Query: 16 YREKGYWQDLPLTDILTRHA-ASDSIAVIDG--ERQLSYRELNQAADNLACSLRRQGIKP 72 Y + L + R+A +IA D E ++Y E + + LA +++R G+ Sbjct: 38 YPLEDGTAGEQLHKAMKRYALVPGTIAFTDAHIEVNITYAEYFEMSVRLAEAMKRYGLNT 97 Query: 73 GETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHAL 132 +V N + ++ L +GVA A + EL + +P ++ ++ Sbjct: 98 NHRIVVCSENSLQFFMPVLGALFIGVAVAPANDIYNERELLNSMNISQPTVVFVSKKG-- 155 Query: 133 FSGDDFLNTFVTEHSSIRVVQLL-------NDSGEHNLQDAINHP----AEDFTATPSPA 181 L + + ++Q + + G ++ + ++ P Sbjct: 156 ------LQKILNVQKKLPIIQKIIIMDSKTDYQGFQSMYTFVTSHLPPGFNEYDFVPESF 209 Query: 182 DE---VAYFQLSGGTTGTPKLIPRTHNDY---YYSVRRSVEICQFTQQTRYLCAIPAAHN 235 D +A S G+TG PK + H + R + Q T L +P H Sbjct: 210 DRDKTIALIMNSSGSTGLPKGVALPHRTACVRFSHARDPIFGNQIIPDTAILSVVPFHHG 269 Query: 236 YAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGES 295 + M + +LG + G VVL L ++ +++ LVP S + ++ + Sbjct: 270 FGMFT--TLGYLICGFRVVLMYRFEEELFLRSLQDYKIQSALLVPTLFSFFAKSTLID-- 325 Query: 296 RAQLASLKLLQVGGARLSATLAARIPAEIGCQ-LQQVFGMAEGLVNYTRLDDSAEKIIHT 354 + L++L + GGA LS + + ++Q +G+ E + + Sbjct: 326 KYDLSNLHEIASGGAPLSKEVGEAVAKRFHLPGIRQGYGLTETTSAILITPE-GDDKPGA 384 Query: 355 QGYPMCPDDEVWVAD-AEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCS 413 G + P E V D G L + G L RGP GY +P+ + D +G+ S Sbjct: 385 VGK-VVPFFEAKVVDLDTGKTLGVNQRGELCVRGPMIMSGYVNNPEATNALIDKDGWLHS 443 Query: 414 GDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEK 473 GD+ D + + + R K I G ++A E+E++LL+HP + A + + D+ GE Sbjct: 444 GDIAYWDEDEHFFIVDRLKSLIKYKGYQVAPAELESILLQHPNIFDAGVAGLPDDDAGEL 503 Query: 474 SCAYLVVK--EPLRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLA 531 A +V++ + + ++ ++ Q KL V VD +P GK+D +++R+ L Sbjct: 504 PAAVVVLEHGKTMTEKEIVDYVASQVTTAKKLRGGVVFVDEVPKGLTGKLDARKIREILI 563 >4EAT-A nrPDB Length = 524 Score = 422 bits (1084), Expect = e-118, Method: Composition-based stats. Identities = 117/523 (22%), Positives = 208/523 (39%), Gaps = 26/523 (4%) Query: 24 DLPLTDILTRHAASDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNV 83 + + T D A +D LS+ +L LA +LR G+K E L+ + + Sbjct: 14 NFAEHLLQTNRVRPDKTAFVDDISSLSFAQLEAQTRQLAAALRAIGVKREERVLLLMLDG 73 Query: 84 AELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADR------QHALFSGDD 137 + + F + G+ PV + ++ + AL D Sbjct: 74 TDWPVAFLGAIYAGIVPVAVNTLLTADDYAYMLEHSRAQAVLVSGALHPVLKAALTKSDH 133 Query: 138 FLNTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTP 197 + + + + + GE + + + A + AD+ A++ S G+TG P Sbjct: 134 EVQRVIVSRPAAPL-----EPGEVDFAEFVGAHAPLEKPAATQADDPAFWLYSSGSTGRP 188 Query: 198 KLIPRTHND-YYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLA 256 K + TH + Y+ S + A Y + + + + + T+++ Sbjct: 189 KGVVHTHANPYWTSELYGRNTLHLREDDVCFSAAKLFFAYGLGNALTFPMTVGATTLLMG 248 Query: 257 ADPSATLCFPL----IEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARL 312 P+ F + + V P + L A SR Q+A L+L G L Sbjct: 249 ERPTPDAVFKRWLGGVGGVKPTVFYGAPTGYAGMLAAP-NLPSRDQVA-LRLASSAGEAL 306 Query: 313 SATLAARIPAEIGCQLQQVFGMAEGLVNY-TRLDDSAEKIIHTQGYPMCPDDEVWVADAE 371 A + R G + G E L + + L D T G+P+ P ++ + Sbjct: 307 PAEIGQRFQRHFGLDIVDGIGSTEMLHIFLSNLPDRVRY--GTTGWPV-PGYQIELRGDG 363 Query: 372 GNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGRE 431 G P+ GE G L GP + Y+ + + F G+ SGD + +G T GR Sbjct: 364 GGPVADGEPGDLYIHGPSSATMYWGNRAKSRDTFQG-GWTKSGDKYVRNDDGSYTYAGRT 422 Query: 432 KDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVK--EPLRAVQV 489 D + G ++ EIE L++HP V+ AA+V + DE K AY+V + + L ++ Sbjct: 423 DDMLKVSGIYVSPFEIEATLVQHPGVLEAAVVGVADEHGLTKPKAYVVPRPGQTLSETEL 482 Query: 490 RRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLAS 532 + F++++ +A +K P V LP TA GK+ + +LR+ + Sbjct: 483 KTFIKDR-LAPYKYPRSTVFVAELPKTATGKIQRFKLREGVLG 524 >4WV3-A nrPDB Length = 529 Score = 420 bits (1080), Expect = e-118, Method: Composition-based stats. Identities = 117/516 (22%), Positives = 212/516 (41%), Gaps = 19/516 (3%) Query: 24 DLPL----TDILTRH--AASDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETAL 77 DLPL DIL R+ ++ A+ +R++++R+++ A+ + +L+ G++ GE Sbjct: 5 DLPLYYNAVDILERNLPVRANKTALFTPDREMTFRQVSNEANQVGNALKGLGVRFGECVG 64 Query: 78 VQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDD 137 + + AE +FF ++KLG V + E +LI ++ Sbjct: 65 LLTLDSAEWVTSFFGIVKLGAIAVGINTLLKPPEYEYILRDCRARVLIVHQEFLPLIESI 124 Query: 138 FLNTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTP 197 N + EH I V+ G + D I A S +++ S GTTG P Sbjct: 125 RGNLPMLEH--IVVIGEGPQEGYLSFNDWIRPQPTTLEAAQSHREDICSLNYSSGTTGGP 182 Query: 198 KLIPRTHNDYYYSVR-RSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLA 256 K IP H DY + + V + + R + ++ V+ Sbjct: 183 KGIPHAHKDYPLTAQLWGVNVLGLRESDRTFALAKLFFTFGTGGNLIFPWYVGASCVLFP 242 Query: 257 -ADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSAT 315 A A+ I + + + P + L ++ S+ L+SL+L L A Sbjct: 243 GAARVASNVLSTISRFKPTIFYNAPTGYAAALA--LKDFSQHDLSSLRLCVSASEALPAA 300 Query: 316 LAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPL 375 L G + G E + + + G P+ E+ + D EG + Sbjct: 301 LWYAWKEATGVDIIDGIGCTENFHIFISNRP-GDIRPGSSGKPV-EGYELKLVDDEGKTV 358 Query: 376 PQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQI 435 P GE+G ++ R Y+ + + + F + +GD +D +GY GR D + Sbjct: 359 PAGEIGNVLLRSETAALSYWHNFEKSRQTFQGE-WLATGDKYFVDADGYYWHAGRSDDML 417 Query: 436 NRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKEP-LRAVQVRRFLR 494 GG ++ E+E+ L++HPAV A++ D+ K A++++K + + + R + Sbjct: 418 KVGGIWVSPVEVESTLIQHPAVQECAVIGCPDQSRLIKPKAFIILKPEQIPSEALIRQIT 477 Query: 495 EQ---GIAEFKLPDRVECVDSLPLTAVGKVDKKQLR 527 + +A +K P +E V LP TA GK+ + +LR Sbjct: 478 DHCTEKMAAYKRPRWIEFVTELPKTATGKIQRFKLR 513 >2D1S-A nrPDB Length = 548 Score = 419 bits (1077), Expect = e-117, Method: Composition-based stats. Identities = 111/524 (21%), Positives = 211/524 (40%), Gaps = 31/524 (5%) Query: 27 LTDILTRHAASDSIAVIDGERQL--SYRELNQAADNLACSLRRQGIKPGETALVQLGNVA 84 L + R+A +IA + + SY E + + L +L+ G+ + N Sbjct: 29 LRKYMERYAKLGAIAFTNAVTGVDYSYAEYLEKSCCLGKALQNYGLVVDGRIALCSENCE 88 Query: 85 ELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVT 144 E +I A L +GV + EL +P ++ + ++ G D + T Sbjct: 89 EFFIPVIAGLFIGVGVAPTNEIYTLRELVHSLGISKPTIVFSSKK-----GLDKVITVQK 143 Query: 145 EHSSIRVVQLLND----SGEHNLQDAIN-------HPAEDFTATPSPADEVAYFQLSGGT 193 ++I+ + +L+ G L I + T ++VA S G+ Sbjct: 144 TVTTIKTIVILDSKVDYRGYQCLDTFIKRNTPPGFQASSFKTVEVDRKEQVALIMNSSGS 203 Query: 194 TGTPKLIPRTHNDY---YYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAG 250 TG PK + TH + + R + Q + T L +P H + M + +LG + G Sbjct: 204 TGLPKGVQLTHENIVTRFSHARDPIYGNQVSPGTAVLTVVPFHHGFGMFT--TLGYLICG 261 Query: 251 GTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGA 310 VV+ ++ ++ LVP ++ ++ E ++ L++L + GGA Sbjct: 262 FRVVMLTKFDEETFLKTLQDYKCTSVILVPTLFAILNKS--ELLNKYDLSNLVEIASGGA 319 Query: 311 RLSATLAARIPAEIGCQ-LQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVAD 369 LS + + ++Q +G+ E + + G + P + V D Sbjct: 320 PLSKEVGEAVARRFNLPGVRQGYGLTETTSAIIITPE-GDDKPGASGK-VVPLFKAKVID 377 Query: 370 -AEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQ 428 L G + +GP +GY +P+ D G+ +GD+ D E + + Sbjct: 378 LDTKKSLGPNRRGEVCVKGPMLMKGYVNNPEATKELIDEEGWLHTGDIGYYDEEKHFFIV 437 Query: 429 GREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVK--EPLRA 486 R K I G ++ E+E++LL+HP++ A + + D + GE A +V++ + + Sbjct: 438 DRLKSLIKYKGYQVPPAELESVLLQHPSIFDAGVAGVPDPVAGELPGAVVVLESGKNMTE 497 Query: 487 VQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWL 530 +V ++ Q +L V VD +P GK+D + +R+ L Sbjct: 498 KEVMDYVASQVSNAKRLRGGVRFVDEVPKGLTGKIDGRAIREIL 541 >5BUS-A nrPDB Length = 494 Score = 416 bits (1070), Expect = e-117, Method: Composition-based stats. Identities = 132/498 (26%), Positives = 224/498 (44%), Gaps = 31/498 (6%) Query: 32 TRHAASDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFF 91 + IA+I ++ +++ EL A+ +A L ++ G+TA + L N AE+ Sbjct: 14 RAQLTPERIALIYEDQTVTFAELFAASKRMAEQLAAHSVRKGDTAAILLQNRAEMVYAVH 73 Query: 92 ALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRV 151 A LGV VL E L+ D + + T I V Sbjct: 74 ACFLLGVKAVLLNTKLSTHERLFQLEDSGSGFLLTDSSFEKKEYEHIVQT-------IDV 126 Query: 152 VQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSV 211 +L+ ++ E +A D A + GTTG PK + +T ++Y+S Sbjct: 127 DELMKEAAEEIEIEAYMQ-----------MDATATLMYTSGTTGKPKGVQQTFGNHYFSA 175 Query: 212 RRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIEKH 271 S T+Q R+L A+P H +S+ + G TVVL S + I +H Sbjct: 176 VSSALNLGITEQDRWLIALPLFHISGLSA--LFKSVIYGMTVVLHQRFSVSDVLHSINRH 233 Query: 272 QVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIGCQLQQV 331 +V + + V L +L+E +R S++ + +GG L E G + Q Sbjct: 234 EVTMISAV----QTMLASLLEETNRCP-ESIRCILLGGGPAPLPLLEEC-REKGFPVFQS 287 Query: 332 FGMAEGLVNYTRL-DDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMTRGPYT 390 +GM E L + + + + + G P+ E+ + + +G E G +M +GP Sbjct: 288 YGMTETCSQIVTLSPEFSMEKLGSAGKPLF-SCEIKI-ERDGQVCEPYEHGEIMVKGPNV 345 Query: 391 FRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENL 450 + Y+ N ++F NG+ +GDL +D EG++ V R D I GGE I E+E++ Sbjct: 346 MKSYFNRESANEASFQ-NGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGENIYPAEVESV 404 Query: 451 LLRHPAVIYAALVSMEDELMGEKSCAYLVVKEPLRAVQVRRFLREQGIAEFKLPDRVECV 510 LL HPAV A + ED+ G+ AYLV+ +P+ A ++ + +E+ +A++K+P + + Sbjct: 405 LLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKER-LAKYKIPAKFFVL 463 Query: 511 DSLPLTAVGKVDKKQLRQ 528 D LP A K+ + QL+ Sbjct: 464 DRLPRNASNKLLRNQLKD 481 >4FUQ-A nrPDB Length = 503 Score = 416 bits (1069), Expect = e-116, Method: Composition-based stats. Identities = 128/496 (25%), Positives = 222/496 (44%), Gaps = 19/496 (3%) Query: 37 SDSIAV-IDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLK 95 +A+ ++SY EL A +A L +G++ G+ Q E + + A ++ Sbjct: 16 PHKLAIETAAGDKISYAELVARAGRVANVLVARGLQVGDRVAAQTEKSVEALVLYLATVR 75 Query: 96 LGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLL 155 G + ++ EL+ + + EP +++ D S D + + + V+ L Sbjct: 76 AGGVYLPLNTAYTLHELDYFITDAEPKIVVCDP-----SKRDGIAAIAAKVGA--TVETL 128 Query: 156 NDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSV 215 G +L DA +E F AD++A + GTTG K +H++ + V Sbjct: 129 GPDGRGSLTDAAAGASEAFATIDRGADDLAAILYTSGTTGRSKGAMLSHDNLASNSLTLV 188 Query: 216 EICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNV 275 + +FT + A+P H + + ++ +F G + L L+ + V Sbjct: 189 DYWRFTPDDVLIHALPIYHTHGLFVASNVTLFARGSMIFL-PKFDPDKILDLMAR--ATV 245 Query: 276 TALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMA 335 VP + LQ+ ++ ++L G A L A A+ G + + +GM Sbjct: 246 LMGVPTFYTRLLQS--PRLTKETTGHMRLFISGSAPLLADTHREWSAKTGHAVLERYGMT 303 Query: 336 EGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAE-GNPLPQGEVGRLMTRGPYTFRGY 394 E +N T +++ G P P V D E G LP+G++G + +GP F+GY Sbjct: 304 ETNMN-TSNPYDGDRVPGAVG-PALPGVSARVTDPETGKELPRGDIGMIEVKGPNVFKGY 361 Query: 395 YKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRH 454 ++ P+ S F +GF+ +GDL ID GY+ + GR KD + GG + +EIE+ + Sbjct: 362 WRMPEKTKSEFRDDGFFITGDLGKIDERGYVHILGRGKDLVITGGFNVYPKEIESEIDAM 421 Query: 455 PAVIYAALVSMEDELMGEKSCAYLVVKE--PLRAVQVRRFLREQGIAEFKLPDRVECVDS 512 P V+ +A++ + GE A +V + + QV L Q +A+FK+P +V VD Sbjct: 422 PGVVESAVIGVPHADFGEGVTAVVVRDKGATIDEAQVLHGLDGQ-LAKFKMPKKVIFVDD 480 Query: 513 LPLTAVGKVDKKQLRQ 528 LP +GKV K LR+ Sbjct: 481 LPRNTMGKVQKNVLRE 496 >3R44-A nrPDB Length = 517 Score = 411 bits (1056), Expect = e-115, Method: Composition-based stats. Identities = 113/490 (23%), Positives = 205/490 (41%), Gaps = 20/490 (4%) Query: 46 ERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALF 105 + +++Y ++N A+ A L GI G+ + + N E F+ KLG V Sbjct: 41 DVRMTYAQMNALANRCADVLTALGIAKGDRVALLMPNSVEFCCLFYGAAKLGAVAVPINT 100 Query: 106 SHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQD 165 E++ S ++I A ++ + V G +L + Sbjct: 101 RLAAPEVSFILSDSGSKVVIYGAPSAP-----VIDAIRAQADPPGTVTDW--IGADSLAE 153 Query: 166 AINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTR 225 + A D A D+ + + GTTG PK + TH + + + R Sbjct: 154 RLRSAAADEPAVECGGDDNLFIMYTSGTTGHPKGVVHTHESVHSAASSWASTIDVRYRDR 213 Query: 226 YLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSL 285 L +P H A+++ + G T++ AT + LI + +V + VP ++ Sbjct: 214 LLLPLPMFHVAALTTVIFSA--MRGVTLISMPQFDATKVWSLIVEERVCIGGAVPAILNF 271 Query: 286 WLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRL- 344 Q + + + GGA + L A+ ++ Q + + E T L Sbjct: 272 MRQ--VPEFAELDAPDFRYFITGGAPMPEALIKIYAAK-NIEVVQGYALTESCGGGTLLL 328 Query: 345 DDSAEKIIHTQGY-PMCPDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNAS 403 + A + + G M D V V +G GE G ++ + + Y+ P+ Sbjct: 329 SEDALRKAGSAGRATMFTD--VAVRGDDGVIREHGE-GEVVIKSDILLKEYWNRPEATRD 385 Query: 404 AFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALV 463 AFD NG++ +GD+ ID EGY+ ++ R KD I GGE + EIE++++ P V A++ Sbjct: 386 AFD-NGWFRTGDIGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVAVI 444 Query: 464 SMEDELMGEKSCAYLVVKE-PLRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVD 522 + DE GE + A +V + + Q+ + + +A +KLP +V +++P GK+ Sbjct: 445 GLPDEKWGEIAAAIVVADQNEVSEQQIVEYCGTR-LARYKLPKKVIFAEAIPRNPTGKIL 503 Query: 523 KKQLRQWLAS 532 K LR+ ++ Sbjct: 504 KTVLREQYSA 513 >2V7B-A nrPDB Length = 529 Score = 408 bits (1048), Expect = e-114, Method: Composition-based stats. Identities = 121/507 (23%), Positives = 218/507 (42%), Gaps = 20/507 (3%) Query: 33 RHAASDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFA 92 + A ID +Y EL + A A +LR G+ P E L+ + + L + F Sbjct: 33 NETRAGKTAYIDDTGSTTYGELEERARRFASALRTLGVHPEERILLVMLDTVALPVAFLG 92 Query: 93 LLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVV 152 L GV PV+A ++ + +IA + EH +++ Sbjct: 93 ALYAGVVPVVANTLLTPADYVYMLTHSHARAVIASGALVQNVTQALESA---EHDGCQLI 149 Query: 153 QLLNDSGEHNL----QDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYY 208 E L ++ I+ A A + D++A++ S G+TG PK TH + Y Sbjct: 150 VSQPRESEPRLAPLFEELIDAAAPAAKAAATGCDDIAFWLYSSGSTGKPKGTVHTHANLY 209 Query: 209 YSVRRSVE-ICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLCFPL 267 ++ + I + A Y + + + + + +++A P+A F Sbjct: 210 WTAELYAKPILGIAENDVVFSAAKLFFAYGLGNGLTFPLSVGATAILMAERPTADAIFAR 269 Query: 268 IEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIGCQ 327 + +H+ V VP + L + +RA +A +++ G L + R A GC+ Sbjct: 270 LVEHRPTVFYGVPTLYANMLVSP-NLPARADVA-IRICTSAGEALPREIGERFTAHFGCE 327 Query: 328 LQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMTRG 387 + G E L + + T G P+ P E+ + D G+ +P GEVG L +G Sbjct: 328 ILDGIGSTEMLHIFLSNR-AGAVEYGTTGRPV-PGYEIELRDEAGHAVPDGEVGDLYIKG 385 Query: 388 PYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEI 447 P Y+ + + + + F + SGD P G GR D + G+ ++ E+ Sbjct: 386 PSAAVMYWNNREKSRATFLGE-WIRSGDKYCRLPNGCYVYAGRSDDMLKVSGQYVSPVEV 444 Query: 448 ENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVK-----EPLRAVQVRRFLREQGIAEFK 502 E +L++H AV+ AA+V + D K+ A++V+K + A +++ F++++ +A K Sbjct: 445 EMVLVQHDAVLEAAVVGV-DHGGLVKTRAFVVLKREFAPSEILAEELKAFVKDR-LAPHK 502 Query: 503 LPDRVECVDSLPLTAVGKVDKKQLRQW 529 P + VD LP TA GK+ + +LR+ Sbjct: 503 YPRDIVFVDDLPKTATGKIQRFKLREQ 529 >3ETC-A nrPDB Length = 580 Score = 405 bits (1040), Expect = e-113, Method: Composition-based stats. Identities = 114/549 (20%), Positives = 209/549 (38%), Gaps = 52/549 (9%) Query: 9 PEEFARRYREKGYWQDLPLTDILTRHAASDSIAVID-----GERQLSYRELNQAADNLAC 63 PE F Y + + + +A+I E+ ++++L +D A Sbjct: 52 PENFNFAYDVVDVYA----------RDSPEKLAMIWCDDYGNEKIFTFKDLKYYSDKAAN 101 Query: 64 SLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPAL 123 + GI G+ ++ L + + + L KLG V A + ++ + + Sbjct: 102 FFVKHGIGKGDYVMLTLKSRYDFWYCMLGLHKLGAIAVPATHMLKTRDIVYRIEKAGLKM 161 Query: 124 LIADRQHALFSGDDFLNTFVTEHSSIRVVQLLN-DSGEHNLQDAINHPAEDFTATP---- 178 ++ + DD H+ + L G L+ I+ E ++P Sbjct: 162 IVC------IAEDDVPEQVDEAHAECGDIPLKKAKVGGDVLEGWIDFRKELEESSPIFER 215 Query: 179 ------SPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPA 232 + +++ S GT G PK++ N Y + + Q + L A Sbjct: 216 PTGEVSTKNEDICLVYFSSGTAGFPKMVEHD-NTYPLGHILTAKYWQNVEDDG-LHYTVA 273 Query: 233 AHNYAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIEK---HQVNVTALVPPAVSLWLQA 289 + G L G V D ++EK + V P ++ Sbjct: 274 DSGWGKCVWGKLYGQWIAGCAVFVYDYDRFEAKNMLEKASKYGVTTFCAPPTIYRFLIK- 332 Query: 290 LIEGESRAQLASLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAE 349 E S ++LK V G L+ + R G +L + FG E +V E Sbjct: 333 --EDLSHYNFSTLKYAVVAGEPLNPEVFNRFLEFTGIKLMEGFGQTETVVTIATFP-WME 389 Query: 350 KIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMT-----RGPYTFRGYYKSPQHNASA 404 + G P P ++ + D +G GE G ++ + F Y K P+ Sbjct: 390 PKPGSIGKP-TPGYKIELMDRDGRLCEVGEEGEIVINTMEGKPVGLFVHYGKDPERTEET 448 Query: 405 FDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVS 464 + +G+Y +GD+ +D +GY+ GR D I G K+ E+E+ L++HPAV+ A+ Sbjct: 449 W-HDGYYHTGDMAWMDEDGYLWFVGRADDIIKTSGYKVGPFEVESALIQHPAVLECAITG 507 Query: 465 MEDELMGEKSCAYLVV-KEPLRAVQVRRFLREQ---GIAEFKLPDRVECVDSLPLTAVGK 520 + D + G+ A +V+ K+ + ++ L++ A +K P +E V LP T GK Sbjct: 508 VPDPVRGQVIKATIVLTKDYTPSDSLKNELQDHVKNVTAPYKYPRIIEFVPELPKTISGK 567 Query: 521 VDKKQLRQW 529 + + ++R Sbjct: 568 IRRVEIRDK 576 >5IE2-A nrPDB Length = 514 Score = 401 bits (1029), Expect = e-112, Method: Composition-based stats. Identities = 121/520 (23%), Positives = 224/520 (43%), Gaps = 33/520 (6%) Query: 26 PLTDILTRHAA--SDSIAV-IDGERQLSYRELNQAADNLACSLRRQ-GIKPGETALVQLG 81 L+ +L A D A+ + G+ L++ L+ + A L GIKPG+ + Sbjct: 5 TLSGLLENVAKKFPDRRALSVSGKFNLTHARLHDLIERAASRLVSDAGIKPGDVVALTFP 64 Query: 82 NVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQ--------HALF 133 N E I F A+++ ++ E Y S + LL+ ++ + Sbjct: 65 NTVEFVIMFLAVIRARATAAPLNAAYTAEEFEFYLSDSDSKLLLTSKEGNAPAQEAASKL 124 Query: 134 SGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGT 193 T + S + + +DS + + +NHP D+ A F + GT Sbjct: 125 KISHVTATLLDAGSDLVLSVADSDSVVDSATELVNHP-----------DDGALFLHTSGT 173 Query: 194 TGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTV 253 T PK +P T + SV+ + + T+ + +P H + + + + Sbjct: 174 TSRPKGVPLTQLNLASSVKNIKAVYKLTESDSTVIVLPLFHVHGLLAGLLSSLGAGAAVT 233 Query: 254 VLAA-DPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARL 312 + AA SAT +P ++K+ VP + L + L+ ++ A L Sbjct: 234 LPAAGRFSATTFWPDMKKYNATWYTAVPTIHQIILDRH-ASHPETEYPKLRFIRSCSASL 292 Query: 313 SATLAARIPAEIGCQLQQVFGMAEGL--VNYTRLDDSAEKIIHTQGYPMCPDDEVWVADA 370 + + +R+ G + + + M E ++ L + + G P+ E+ + + Sbjct: 293 APVILSRLEEAFGAPVLEAYAMTEATHLMSSNPLPEEGPHKPGSVGKPV--GQEMAILNE 350 Query: 371 EGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGR 430 +G G + RGP +GY +P+ N + F+ G++ +GD+ D +GY+ + GR Sbjct: 351 KGEIQEPNNKGEVCIRGPNVTKGYKNNPEANKAGFEF-GWFHTGDIGYFDTDGYLHLVGR 409 Query: 431 EKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKE--PLRAVQ 488 K+ INRGGEKI+ E++ +LL HP V + DE GE+ ++ +E + Sbjct: 410 IKELINRGGEKISPIEVDAVLLTHPDVSQGVAFGVPDEKYGEEINCAVIPREGTTVTEED 469 Query: 489 VRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQ 528 ++ F ++ +A FK+P RV D+LP TA GK+ ++ + Q Sbjct: 470 IKAFCKKN-LAAFKVPKRVFITDNLPKTASGKIQRRIVAQ 508 >3IVR-A nrPDB Length = 509 Score = 395 bits (1014), Expect = e-110, Method: Composition-based stats. Identities = 128/514 (24%), Positives = 213/514 (41%), Gaps = 30/514 (5%) Query: 23 QDLPLTDILTRHAA--SDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQL 80 D L D+ R+AA D A + +L++R+ A+ LA L R G+ G+ + Sbjct: 4 HDFTLADVYRRNAALFPDRTAFMVDGVRLTHRDYLARAERLASGLLRDGVHTGDRVAILS 63 Query: 81 GNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLN 140 N +E+ A+ +G + + E+ P++++A G D+ + Sbjct: 64 QNCSEMIELIGAVALIGAILLPVNYRLNADEIAFVLGDGAPSVVVA--------GTDYRD 115 Query: 141 TFVTEHSSIRVVQLLNDSGEHNLQDAI--NHPAEDFTATPS-PADEVAYFQLSGGTTGTP 197 S+ V+ G+ + A + ++ + P A + + G P Sbjct: 116 IVAGVLPSLGGVKKAYAIGDGSGPFAPFKDLASDTPFSAPEFGAADGFVIIHTAAVGGRP 175 Query: 198 KLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAA 257 + + + + V+ + T+ L +P H + +L AGG V+AA Sbjct: 176 RGALISQGNLLIAQSSLVDAWRLTEADVNLGMLPLFHVTGLGLMLTL--QQAGGASVIAA 233 Query: 258 DPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLA 317 IE H+V V A P L +++ + AQLASL+ + G T+ Sbjct: 234 KFDPAQAARDIEAHKVTVMAEFAP----MLGNILDQAAPAQLASLRAVT--GLDTPETIE 287 Query: 318 ARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQ 377 FG +E T + G P+ V V DAE PLP Sbjct: 288 RFEATCPNATFWATFGQSETSGLSTFAPYRDR--PKSAGRPLFWR-TVAVVDAEDRPLPP 344 Query: 378 GEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGRE--KDQI 435 GEVG ++ RGP F+GY+ + AF NG++ +GD+ D +GY+ GR K+ I Sbjct: 345 GEVGEIVLRGPTVFKGYWNNAAATQHAFR-NGWHHTGDMGRFDADGYLFYAGRAPEKELI 403 Query: 436 NRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVK--EPLRAVQVRRFL 493 GGE + E+E L +HPA+ A ++ + D E A V K E + A + F+ Sbjct: 404 KTGGENVYPAEVEGALKQHPAIADAVVIGVPDPQWSEAIKAVCVCKPGESIAADALAEFV 463 Query: 494 REQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLR 527 IA +K P V V++LP A G +D+ ++ Sbjct: 464 AS-LIARYKKPKHVVFVEALPKDAKGAIDRAAVK 496 >5U29-A nrPDB Length = 694 Score = 392 bits (1006), Expect = e-109, Method: Composition-based stats. Identities = 106/539 (19%), Positives = 203/539 (37%), Gaps = 42/539 (7%) Query: 37 SDSIAVIDGE------RQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITF 90 A+I R++SY EL Q +A L+ G+K G+ + L + F Sbjct: 131 PKKTAIIYEADEPSESREVSYEELMQETCRVANVLKSYGVKKGDAVSIYLPMTWQAAAAF 190 Query: 91 FALLKLGVA--PVLALFSHQ--RSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEH 146 A ++G V A FS + R +N ++ R + ++ + + Sbjct: 191 LACARIGAIHSAVFAGFSAESLRDRVNDCECKVLITTDEGRRGGKTIATKQIVDAALQQC 250 Query: 147 SSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPA---------DEVAYFQLSGGTTGTP 197 + V +L +G D PA ++ + + G+TG P Sbjct: 251 PLVENVLVLRRTGNKVPMTEGRDKWWDEECAKMPAYCPCERMASEDPLFILYTSGSTGKP 310 Query: 198 KLIPRTHNDYYYSVRRSVEI-CQFTQQTRYLCAIP----AAHNYAMSSPGSLGVFLAGGT 252 K + + Y +++ R+ C H+Y + P + G+ A Sbjct: 311 KGVVHSTAGYLLGTALTLKYVFDAHPDDRFACMADIGWITGHSYIIYGPLANGITTAVFE 370 Query: 253 VVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARL 312 P+ + + ++K + P A+ L + + L+SL++L G + Sbjct: 371 STPVY-PTPSRYWDFVDKWKATQLYTAPTAIRLLRRMGEDHVKNHDLSSLRVLGSVGEPI 429 Query: 313 SATLAAR---IPAEIGCQLQQVFGMAE-GLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVA 368 + + C + + M E G ++ L + + +P D + Sbjct: 430 NPEAWHWYNDFAGKNQCAIVDTYWMTETGSISIAPLPGAISTKPGSATFPFFGMDVDIID 489 Query: 369 DAEGNPLPQGEV-GRLMTRGPY--TFRGYYKSPQHNASAF--DANGFYCSGDLISIDPEG 423 G L +V G L+ R P+ R Y+ + + G++ GD + D +G Sbjct: 490 PQTGQVLEGNDVEGVLVARRPWPSIARTVYRDHKRYLETYMKPYPGYFFFGDGAARDYDG 549 Query: 424 YITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKEP 483 Y+ ++GR D IN G +++ E+E+ L+ H V A+V D+L G+ A++ +K Sbjct: 550 YMWIKGRVDDVINVSGHRLSTAEVESALILHKGVAETAVVGCADDLTGQAVYAFVTMKPE 609 Query: 484 L-----RAVQVRRFLR---EQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLASRA 534 + + + L + I F P ++ V LP T GK+ ++ LR+ +A Sbjct: 610 FDLKATKEADLSKELAIQVRKVIGPFAAPKKIYLVSDLPKTRSGKIMRRVLRKIVAGEG 668 >5JRH-A nrPDB Length = 660 Score = 391 bits (1003), Expect = e-109, Method: Composition-based stats. Identities = 119/562 (21%), Positives = 213/562 (37%), Gaps = 53/562 (9%) Query: 21 YWQDLPL---TDILTRHAA--SDSIAVIDGE------RQLSYRELNQAADNLACSLRRQG 69 +++D L + L RH D A+I + +SYREL++ A +L G Sbjct: 69 WYEDGTLNLAANCLDRHLQENGDRTAIIWEGDDTSQSKHISYRELHRDVCRFANTLLDLG 128 Query: 70 IKPGETALVQLGNVAELYITFFALLKLGVA--PVLALFSHQR--SELNAYASQIEPALLI 125 IK G+ + + V E + A ++G + FS + + +S++ Sbjct: 129 IKKGDVVAIYMPMVPEAAVAMLACARIGAVHSVIFGGFSPEAVAGRIIDSSSRLVITADE 188 Query: 126 ADRQHALFSGDDFLNTFVTEH--SSIRVVQLLNDSGEHN---------LQDAINHPAEDF 174 R ++ + +S+ V +L +G +D I + + Sbjct: 189 GVRAGRSIPLKKNVDDALKNPNVTSVEHVIVLKRTGSDIDWQEGRDLWWRDLIEKASPEH 248 Query: 175 TATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYY-YSVRRSVEICQFTQQTRYLCAIP-- 231 A++ + + G+TG PK + T Y Y+ + + Y C Sbjct: 249 QPEAMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAATTFKYVFDYHPGDIYWCTADVG 308 Query: 232 --AAHNYAMSSPGSLGVFLAGGTVVLAADPS---ATLCFPLIEKHQVNVTALVPPAVSLW 286 H+Y + P + G T++ P+ +++KHQVN+ P A+ Sbjct: 309 WVTGHSYLLYGPLACG----ATTLMFEGVPNWPTPARMCQVVDKHQVNILYTAPTAIRAL 364 Query: 287 LQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIG---CQLQQVFGMAEGLV-NYT 342 + + +SL++L G ++ +IG C + + E T Sbjct: 365 MAEGDKAIEGTDRSSLRILGSVGEPINPEAWEWYWKKIGKEKCPVVDTWWQTETGGFMIT 424 Query: 343 RLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMTRG--PYTFRGYYKSPQH 400 L + E + P + D EG+P G L+ P R + + Sbjct: 425 PLPGAIELKAGSATRPFFGVQPA-LVDNEGHPQEGATEGNLVITDSWPGQARTLFGDHER 483 Query: 401 NASAF--DANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVI 458 + Y SGD D +GY + GR D +N G ++ EIE+ L+ HP + Sbjct: 484 FEQTYFSTFKNMYFSGDGARRDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKIA 543 Query: 459 YAALVSMEDELMGEKSCAYLVVKE-----PLRAVQVRRFLREQGIAEFKLPDRVECVDSL 513 AA+V + + G+ AY+ + P +VR ++R++ I PD + DSL Sbjct: 544 EAAVVGIPHAIKGQAIYAYVTLNHGEEPSPELYAEVRNWVRKE-IGPLATPDVLHWTDSL 602 Query: 514 PLTAVGKVDKKQLRQWLASRAS 535 P T GK+ ++ LR+ A S Sbjct: 603 PKTRSGKIMRRILRKIAAGDTS 624 >1RY2-A nrPDB Length = 663 Score = 390 bits (1002), Expect = e-109, Method: Composition-based stats. Identities = 110/527 (20%), Positives = 203/527 (38%), Gaps = 40/527 (7%) Query: 48 QLSYRELNQAADNLACSLR-RQGIKPGETALVQLGNVAELYITFFALLKLGVA--PVLAL 104 ++Y+EL + +A L G++ G+T V + V E IT A+ ++G V A Sbjct: 113 SITYKELLEEVCQVAQVLTYSMGVRKGDTVAVYMPMVPEAIITLLAISRIGAIHSVVFAG 172 Query: 105 FSHQ--RSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSG--- 159 FS R +N S++ ++R + ++ + E +R V + + Sbjct: 173 FSSNSLRDRINDGDSKVVITTDESNRGGKVIETKRIVDDALRETPGVRHVLVYRKTNNPS 232 Query: 160 -------EHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVR 212 + + + TP +++ + + G+TG PK + + Y Sbjct: 233 VAFHAPRDLDWATEKKKYKTYYPCTPVDSEDPLFLLYTSGSTGAPKGVQHSTAGYLLGAL 292 Query: 213 RSVEI-CQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVL---AADPSATLCFPLI 268 ++ Q+ + A + + T+V A P+ + + +I Sbjct: 293 LTMRYTFDTHQEDVFFTAGDIGWITGHTYVVYGPLLYGCATLVFEGTPAYPNYSRYWDII 352 Query: 269 EKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIG--- 325 ++H+V + P A+ L +A L SL+ L G ++A + +IG Sbjct: 353 DEHKVTQFYVAPTALRLLKRAGDSYIENHSLKSLRCLGSVGEPIAAEVWEWYSEKIGKNE 412 Query: 326 CQLQQVFGMAE-GLVNYTRL-DDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGE-VGR 382 + + E G T L + +P D V + G L G Sbjct: 413 IPIVDTYWQTESGSHLVTPLAGGVTPMKPGSASFPFFGIDAVVLDPNTGEELNTSHAEGV 472 Query: 383 LMTRG--PYTFRGYYKSPQHNASAF--DANGFYCSGDLISIDPEGYITVQGREKDQINRG 438 L + P R +K+ + G+Y +GD + D +GYI + GR D +N Sbjct: 473 LAVKAAWPSFARTIWKNHDRYLDTYLNPYPGYYFTGDGAAKDKDGYIWILGRVDDVVNVS 532 Query: 439 GEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVK-----EPLRAVQVRR-- 491 G +++ EIE ++ P V A+V D+L G+ A++V+K +++ Sbjct: 533 GHRLSTAEIEAAIIEDPIVAECAVVGFNDDLTGQAVAAFVVLKNKSSWSTATDDELQDIK 592 Query: 492 ----FLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLASRA 534 F + I F P + VD LP T GK+ ++ LR+ LA + Sbjct: 593 KHLVFTVRKDIGPFAAPKLIILVDDLPKTRSGKIMRRILRKILAGES 639 >3GPC-A nrPDB Length = 570 Score = 382 bits (981), Expect = e-106, Method: Composition-based stats. Identities = 105/543 (19%), Positives = 200/543 (36%), Gaps = 39/543 (7%) Query: 9 PEEFARRYREKGYWQDLPLTDILTRHAASDSIAVID-----GERQLSYRELNQAADNLAC 63 P +F +W D+ S A+ E ++REL++ + A Sbjct: 34 PAKFNFASDVLDHWADME-----KAGKRPPSPALWWVNGKGKELMWNFRELSENSQQAAN 88 Query: 64 SLRRQ-GIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPA 122 L G++ G+ V L V E ++ ++ G+ + + +++ + Sbjct: 89 VLSGACGLQRGDRVAVVLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAK 148 Query: 123 LLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDS---GEHNLQDAINHPAEDFTATPS 179 ++A + ++T +E S+R+ L+++ G N + +N + + Sbjct: 149 AIVAGDEVI-----QEVDTVASECPSLRIKLLVSEKSCDGWLNFKKLLNEASTTHHCVET 203 Query: 180 PADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNY-AM 238 + E + + GT+G PK+ +++ + + Sbjct: 204 GSQEASAIYFTSGTSGLPKMAEHSYSSLGLKAKMDAGWTGLQASDIMWTISDTGWILNIL 263 Query: 239 SSPGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQ 298 S A V L + + + + P + LQ S + Sbjct: 264 CSLMEPWALGACTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLLQQ---DLSSYK 320 Query: 299 LASLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYP 358 L+ G L A+ G +++ +G E + + + G Sbjct: 321 FPHLQNCVTVGESLLPETLENWRAQTGLDIRESYGQTET-GLTCMVSKTMKIKPGYMG-T 378 Query: 359 MCPDDEVWVADAEGNPLPQGEVGRLMTR-GPY----TFRGYYKSPQHNASAFDANGFYCS 413 +V + D +GN LP G G + R P F GY +P A+ + F+ Sbjct: 379 AASCYDVQIIDDKGNVLPPGTEGDIGIRVKPIRPIGIFSGYVDNPDKTAANIRGD-FWLL 437 Query: 414 GDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEK 473 GD D +GY GR D IN G +I E+EN L+ HPAV+ A++S D + GE Sbjct: 438 GDRGIKDEDGYFQFMGRADDIINSSGYRIGPSEVENALMEHPAVVETAVISSPDPVRGEV 497 Query: 474 SCAYLVV-------KEPLRAVQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQL 526 A++V+ ++++ ++ A +K P ++E V +LP T GK+ + +L Sbjct: 498 VKAFVVLASQFLSHDPEQLTKELQQHVKS-VTAPYKYPRKIEFVLNLPKTVTGKIQRAKL 556 Query: 527 RQW 529 R Sbjct: 557 RDK 559 >5ES8-A nrPDB Length = 776 Score = 380 bits (975), Expect = e-106, Method: Composition-based stats. Identities = 106/515 (20%), Positives = 194/515 (37%), Gaps = 48/515 (9%) Query: 23 QDLPLTDILTRHAA--SDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQL 80 D + + D +AV+D + L+Y++LN+ A+ LA LR +G+KP + + L Sbjct: 201 IDKTFHQLFEQQVEMTPDHVAVVDRGQSLTYKQLNERANQLAHHLRGKGVKPDDQVAIML 260 Query: 81 GNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLN 140 ++ ++ A++K G A V + + + A+L+ + Sbjct: 261 DKSLDMIVSILAVMKAGGAYVPIDPDYPGERIAYMLADSSAAILLTN------------- 307 Query: 141 TFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLI 200 + E + +++ + + N+ + D++ Y + G+TG K + Sbjct: 308 -ALHEEKANGACDIIDVHDPDSYSENTNN-----LPHVNRPDDLVYVMYTSGSTGLAKGV 361 Query: 201 PRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPS 260 H++ V C++ + Y PA SS G L T +LA + Sbjct: 362 MIEHHNL-------VNFCEWYRP--YFGVTPADKALVYSSFSFDGSALDIFTHLLAG--A 410 Query: 261 ATLCFPLIEKHQVNVTALVPPAVSLWLQALI----EGESRAQLASLKLLQVGGARLSATL 316 A P K+ ++ + + L E + S +++ GG L Sbjct: 411 ALHIVPSERKYDLDALNDYCNQEGITISYLPTGAAEQFMQMDNQSFRVVITGGDVL---- 466 Query: 317 AARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLP 376 +I +L +G E + T + G P+ + + D P Sbjct: 467 -KKIERNGTYKLYNGYGPTECTIMVTMFEVDKPYANIPIGKPI-DRTRILILDEALALQP 524 Query: 377 QGEVGRLMTRGPYTFRGYYKSPQHNASAF-----DANGFYCSGDLISIDPEGYITVQGRE 431 G G L G RGY P+ A F Y +GD P+G I GR Sbjct: 525 IGVAGELFIVGEGLGRGYLNRPELTAEKFIVHPQTGERMYRTGDRARFLPDGNIEFLGRL 584 Query: 432 KDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKEPLRAVQVRR 491 + + G +I EIE L+ HP + +++ E + Y V E + ++R Sbjct: 585 DNLVKIRGYRIEPGEIEPFLMNHPLIELTTVLAKEQADGRKYLVGYYVAPEEIPHGELRE 644 Query: 492 FLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQL 526 +L + ++ +P + + PLTA GKVD++ L Sbjct: 645 WL-GNDLPDYMIPTYFVHMKAFPLTANGKVDRRAL 678 >5ES6-A nrPDB Length = 685 Score = 379 bits (973), Expect = e-105, Method: Composition-based stats. Identities = 106/515 (20%), Positives = 194/515 (37%), Gaps = 48/515 (9%) Query: 23 QDLPLTDILTRHAA--SDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQL 80 D + + D +AV+D + L+Y++LN+ A+ LA LR +G+KP + + L Sbjct: 201 IDKTFHQLFEQQVEMTPDHVAVVDRGQSLTYKQLNERANQLAHHLRGKGVKPDDQVAIML 260 Query: 81 GNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLN 140 ++ ++ A++K G A V + + + A+L+ + Sbjct: 261 DKSLDMIVSILAVMKAGGAYVPIDPDYPGERIAYMLADSSAAILLTN------------- 307 Query: 141 TFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLI 200 + E + +++ + + N+ + D++ Y + G+TG K + Sbjct: 308 -ALHEEKANGACDIIDVHDPDSYSENTNN-----LPHVNRPDDLVYVMYTSGSTGLAKGV 361 Query: 201 PRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPS 260 H++ V C++ + Y PA SS G L T +LA + Sbjct: 362 MIEHHNL-------VNFCEWYRP--YFGVTPADKALVYSSFSFDGSALDIFTHLLAG--A 410 Query: 261 ATLCFPLIEKHQVNVTALVPPAVSLWLQALI----EGESRAQLASLKLLQVGGARLSATL 316 A P K+ ++ + + L E + S +++ GG L Sbjct: 411 ALHIVPSERKYDLDALNDYCNQEGITISYLPTGAAEQFMQMDNQSFRVVITGGDVL---- 466 Query: 317 AARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLP 376 +I +L +G E + T + G P+ + + D P Sbjct: 467 -KKIERNGTYKLYNGYGPTECTIMVTMFEVDKPYANIPIGKPI-DRTRILILDEALALQP 524 Query: 377 QGEVGRLMTRGPYTFRGYYKSPQHNASAF-----DANGFYCSGDLISIDPEGYITVQGRE 431 G G L G RGY P+ A F Y +GD P+G I GR Sbjct: 525 IGVAGELFIVGEGLGRGYLNRPELTAEKFIVHPQTGERMYRTGDRARFLPDGNIEFLGRL 584 Query: 432 KDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKEPLRAVQVRR 491 + + G +I EIE L+ HP + +++ E + Y V E + ++R Sbjct: 585 DNLVKIRGYRIEPGEIEPFLMNHPLIELTTVLAKEQADGRKYLVGYYVAPEEIPHGELRE 644 Query: 492 FLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQL 526 +L + ++ +P + + PLTA GKVD++ L Sbjct: 645 WL-GNDLPDYMIPTYFVHMKAFPLTANGKVDRRAL 678 >3FCE-A nrPDB Length = 512 Score = 374 bits (960), Expect = e-104, Method: Composition-based stats. Identities = 105/513 (20%), Positives = 190/513 (37%), Gaps = 40/513 (7%) Query: 37 SDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKL 96 D A + + +++Y++L + +D LA + + +V E+ I F +K Sbjct: 15 PDQTAFVWRDAKITYKQLKEDSDALAHWISSEYPDDRSPIMVYGHMQPEMIINFLGCVKA 74 Query: 97 GVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLN 156 G A + S + A LL++ +R+V Sbjct: 75 GHAYIPVDLSIPADRVQRIAENSGAKLLLSA------------TAVTVTDLPVRIV---- 118 Query: 157 DSGEHNLQD-AINHPAEDFTAT-PSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRS 214 E NL+D H DE Y + G+TG PK + T+N + + Sbjct: 119 --SEDNLKDIFFTHKGNTPNPEHAVKGDENFYIIYTSGSTGNPKGVQITYNCLVSFTKWA 176 Query: 215 VEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADP---SATLCFPLIEKH 271 VE +L P ++ +S + GGT+ F +E+ Sbjct: 177 VEDFNLQTGQVFLNQAPF--SFDLSVMDIYPSLVTGGTLWAIDKDMIARPKDLFASLEQS 234 Query: 272 QVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEI-GCQLQQ 330 + V P + L + S + L ++K G L +A ++ + Sbjct: 235 DIQVWTSTPSFAEMCL--MEASFSESMLPNMKTFLFCGEVLPNEVARKLIERFPKATIMN 292 Query: 331 VFGMAEGLVNYTRLDDSAEKIIHTQGYPMCP---DDEVWVADAEGNPLPQGEVGRLMTRG 387 +G E V T + + E + + P+ D + + +G P GE G ++ G Sbjct: 293 TYGPTEATVAVTGIHVTEEVLDQYKSLPVGYCKSDCRLLIMKEDGTIAPDGEKGEIVIVG 352 Query: 388 PYTFRGYYKSPQHNASAF---DANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAA 444 P GY SP+ AF D Y +GD + G + GR QI G ++ Sbjct: 353 PSVSVGYLGSPELTEKAFTMIDGERAYKTGDAGYV-ENGLLFYNGRLDFQIKLHGYRMEL 411 Query: 445 EEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKE--PLRAVQVRRFLREQG---IA 499 EEIE+ L V A +V ++ + A +V E + ++ ++++ + Sbjct: 412 EEIEHHLRACSYVEGAVIVPIKKGEKYDYLLAVVVPGEHSFEKEFKLTSAIKKELNERLP 471 Query: 500 EFKLPDRVECVDSLPLTAVGKVDKKQLRQWLAS 532 + +P + S+P+T GKVD+K+L + + Sbjct: 472 NYMIPRKFMYQSSIPMTPNGKVDRKKLLSEVTA 504 >4LGC-A nrPDB Length = 539 Score = 371 bits (952), Expect = e-103, Method: Composition-based stats. Identities = 121/511 (23%), Positives = 211/511 (41%), Gaps = 46/511 (9%) Query: 36 ASDSIAVIDGERQ-----LSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITF 90 DS AVI +++ +++ +L+ + LA L I PG L N E I Sbjct: 62 KPDSTAVICLDKEQNCSVITWHQLHVYSSQLAWYLIENEIGPGSIVLTMFPNSIEHIIAV 121 Query: 91 FALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIR 150 FA+ K G + + SE+ I P A+ + G F S+ Sbjct: 122 FAIWKAGACYMPMSYKAAESEIREACDTIHPNAAFAECK---IPGLKFC------LSADE 172 Query: 151 VVQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLI----PRTHND 206 + + + + D + +P LSGGT+G K I P +D Sbjct: 173 IYEAMEGRSKEMPSDRLANPN--------------MISLSGGTSGKMKFIRQNLPCGLDD 218 Query: 207 YYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLCFP 266 ++R + + R L P H A S G+F+ G T+VL + Sbjct: 219 E--TIRSWSLMSGMGFEQRQLLVGPLFHG-APHSAAFNGLFM-GNTLVLTRNLCPGNILN 274 Query: 267 LIEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIG- 325 +I+K+++ +VP ++ + +EG + ASLK L G S L +G Sbjct: 275 MIKKYKIEFIQMVPTLMNRLAK--LEGVGKEDFASLKALCHTGGVCSPWLKQIWIDLLGP 332 Query: 326 CQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMT 385 ++ +++ M E + D K + G P+ D +V + D G + E+G + Sbjct: 333 EKIYEMYSMTECIGLTCIRGDEWVKHPGSIGRPV-GDSKVSIRDENGKEVAPFEIGEIYM 391 Query: 386 RGPYTFRGYYKSPQHNASAFDAN--GFYCSGDLISIDPEGYITVQGREKDQINRGGEKIA 443 P + Y + N + GF GD+ +D +GY+ R D + GGE + Sbjct: 392 TAPAS---YLVTEYINWEPLEVKEGGFRSVGDIGYVDEQGYLYFSDRRSDMLVSGGENVF 448 Query: 444 AEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKEPLRAVQVRRFLREQGIAEFKL 503 A E+E LLR+ ++ A +V + DE +G + A + + + A +++ FLR+ + +K+ Sbjct: 449 ATEVETALLRYKDILDAVVVGIPDEDLGRRLHAVIETGKEIPAEELKTFLRKY-LTPYKI 507 Query: 504 PDRVECVDSLPLTAVGKVDKKQLRQWLASRA 534 P E V S+ GK D+K++ + +R Sbjct: 508 PKTFEFVRSIRRGDNGKADRKRILEDCIARG 538 >3E7W-A nrPDB Length = 511 Score = 367 bits (942), Expect = e-102, Method: Composition-based stats. Identities = 105/514 (20%), Positives = 201/514 (39%), Gaps = 39/514 (7%) Query: 37 SDSIAVIDGERQLSYRELNQAADNLACSLRRQGIK-PGETALVQLGNVAELYITFFALLK 95 + A + L+Y+EL + +D A +++++ LV + ++F +K Sbjct: 15 PQTDAFRSQGQSLTYQELWEQSDRAAAAIQKRISGEKKSPILVYGHMEPHMIVSFLGSVK 74 Query: 96 LGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLL 155 G + S + LLI + ++ + ++ +LL Sbjct: 75 AGHPYIPVDLSIPSERIAKIIESSGAELLI-------HAAGLSIDAVGQQIQTVSAEELL 127 Query: 156 NDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSV 215 + G QD E F Y + G+TG PK + + + Sbjct: 128 ENEGGSVSQDQWVKEHETF-----------YIIYTSGSTGNPKGVQISAANLQSFTDWIC 176 Query: 216 EICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPS---ATLCFPLIEKHQ 272 + +L P ++ +S +GGT+ + + F ++K Sbjct: 177 ADFPVSGGKIFLNQAPF--SFDLSVMDLYPCLQSGGTLHCVTKDAVNKPKVLFEELKKSG 234 Query: 273 VNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEI-GCQLQQV 331 +NV P V + L + G S+ L G L ++A + ++ Sbjct: 235 LNVWTSTPSFVQMCL--MDPGFSQDLLPHADTFMFCGEVLPVSVAKALLERFPKAKIFNT 292 Query: 332 FGMAEGLVNYTRLDDSAEKIIHTQGYPMC---PDDEVWVADAEGNPLPQGEVGRLMTRGP 388 +G E V T ++ + + I ++ P+ PD +++ D EG PLP+GE G ++ GP Sbjct: 293 YGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDEEGQPLPEGEKGEIVIAGP 352 Query: 389 YTFRGYYKSPQHNASAF---DANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAE 445 RGY P+ AF + Y +GD I +G I QGR QI G ++ E Sbjct: 353 SVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFI-QDGQIFCQGRLDFQIKLHGYRMELE 411 Query: 446 EIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVK--EPLRAVQVRRFLREQ---GIAE 500 EIE + + V A ++ + E A +V + E + Q+ ++++ + Sbjct: 412 EIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHEFEKEFQLTSAIKKELAASLPA 471 Query: 501 FKLPDRVECVDSLPLTAVGKVDKKQLRQWLASRA 534 + +P + D + +TA GK+D+K++ + + R+ Sbjct: 472 YMIPRKFIYQDHIQMTANGKIDRKRIGEEVLVRS 505 >3DLP-X nrPDB Length = 504 Score = 364 bits (934), Expect = e-101, Method: Composition-based stats. Identities = 126/523 (24%), Positives = 203/523 (38%), Gaps = 35/523 (6%) Query: 25 LPLTDILTRHA--ASDSIAVIDGER--QLSYRELNQAADNLACSLRRQGIKPGETALVQL 80 + ++L R A A D A+ R +L++ EL + +A L G++P + V Sbjct: 2 QTVNEMLRRAATRAPDHCALAVPARGLRLTHAELRARVEAVAARLHADGLRPQQRVAVVA 61 Query: 81 GNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLN 140 N A++ I AL +LG P L + +EL + E + G + Sbjct: 62 PNSADVVIAILALHRLGAVPALLNPRLKSAELAELIKRGEMTA------AVIAVGRQVAD 115 Query: 141 TFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLI 200 S R++ L D + P ED P+ + A+ + GTTG PK Sbjct: 116 AIFQSGSGARII-FLGDLVRDGEPYSYGPPIEDPQREPA---QPAFIFYTSGTTGLPKAA 171 Query: 201 PRTHNDYYYSV--RRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAAD 258 V + + + L +P H + + L G T V+ + Sbjct: 172 IIPQRAAESRVLFMSTQVGLRHGRHNVVLGLMPLYHVVGFFAVLVAALALDG-TYVVVEE 230 Query: 259 PSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAA 318 L+++ QV P + A S +L SL+ + GA + + Sbjct: 231 FRPVDALQLVQQEQVTSLFATPTHLDALAAAAAHAGSSLKLDSLRHVTFAGATMPDAVLE 290 Query: 319 RIPAEIGCQLQQVFGMAEGL-VNYTRLDDSAEKIIHTQGYPMCPD--DEVWVADAEG--- 372 + + + ++G E + Y R + G M P EV + G Sbjct: 291 TVHQHLPGEKVNIYGTTEAMNSLYMRQPKT--------GTEMAPGFFSEVRIVRIGGGVD 342 Query: 373 NPLPQGEVGRLMTRG-PYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGRE 431 + GE G L+ F GY PQ A +G+Y + D+ PEG + + GR Sbjct: 343 EIVANGEEGELIVAASDSAFVGYLNQPQATAEKLQ-DGWYRTSDVAVWTPEGTVRILGRV 401 Query: 432 KDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVK--EPLRAVQV 489 D I GGE I EIE +L P V ++ + D+ G+ A +V + E L A + Sbjct: 402 PDMIISGGENIHPSEIERVLGTAPGVTEVVVIGLADQRWGQSVTACVVPRLGETLSADAL 461 Query: 490 RRFLREQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLAS 532 F R +A+FK P R +D LP A+ KV ++QL Q ++S Sbjct: 462 DTFCRSSELADFKRPKRYFILDQLPKNALNKVLRRQLVQQVSS 504 >3IPL-A nrPDB Length = 501 Score = 359 bits (920), Expect = 2e-99, Method: Composition-based stats. Identities = 116/497 (23%), Positives = 203/497 (40%), Gaps = 27/497 (5%) Query: 37 SDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKL 96 IA+ DG+ +Y+ L A LA L+ + + N + I A Sbjct: 15 GHHIAITDGQESYTYQNLYCEASLLAKRLKAY---QQSRVGLYIDNSIQSIILIHACWLA 71 Query: 97 GVAPVLALFSHQRSELNAYASQIEPALLIADRQHAL----FSGDDFLNTFVTEHSSIRVV 152 + + +E+ I+ L+ L D + + ++ ++ Sbjct: 72 NIEIAMINTRLTPNEMTNQMRSIDVQLIFCTLPLELRGFQIVSLDDIEFAGRDITTNGLL 131 Query: 153 QLLNDSGEHNLQDAINHPAE--DFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYS 210 + + + T D++A + GTTG K +P+T ++Y S Sbjct: 132 DNTMGIQYDTSNETVVPKESPSNILNTSFNLDDIASIMFTSGTTGPQKAVPQTFRNHYAS 191 Query: 211 VRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIEK 270 E F + T +L +P H +S L + G TV + +A +I+ Sbjct: 192 AIGCKESLGFDRDTNWLSVLPIYHISGLSV--LLRAVIEGFTVRIVDKFNAEQILTMIKN 249 Query: 271 HQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIGCQLQQ 330 ++ +LVP ++ +Q + + +L+ + +GGA+LSAT+ + + Sbjct: 250 ERITHISLVPQTLNWLMQQGL-----HEPYNLQKILLGGAKLSATMIET-ALQYNLPIYN 303 Query: 331 VFGMAEGLVNY-TRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMTRGPY 389 FGM E + T + T G P D V + NP +G G LM +G Sbjct: 304 SFGMTETCSQFLTATPEMLHARPDTVGMPSANVD-VKIK----NPNKEGH-GELMIKGAN 357 Query: 390 TFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIEN 449 GY P F+ NG++ +GD+ ID EGY+ + R KD I GGE I +IE Sbjct: 358 VMNGYLY-PTDLTGTFE-NGYFNTGDIAEIDHEGYVMIYDRRKDLIISGGENIYPYQIET 415 Query: 450 LLLRHPAVIYAALVSMEDELMGEKSCAYLVVKEPLRAVQVRRFLREQGIAEFKLPDRVEC 509 + + P + A V D+ G+ Y V + + Q+ +L + +A++K+P E Sbjct: 416 VAKQFPGISDAVCVGHPDDTWGQVPKLYFVSESDISKAQLIAYLSKH-LAKYKVPKHFEK 474 Query: 510 VDSLPLTAVGKVDKKQL 526 VD+LP T+ GK+ + +L Sbjct: 475 VDTLPYTSTGKLQRNKL 491 >1V25-A nrPDB Length = 541 Score = 347 bits (891), Expect = 6e-96, Method: Composition-based stats. Identities = 116/497 (23%), Positives = 202/497 (40%), Gaps = 25/497 (5%) Query: 48 QLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSH 107 + +Y E+ Q A L LR G+ G+ N +FA+ +G A Sbjct: 47 RTTYAEVYQRARRLMGGLRALGVGVGDRVATLGFNHFRHLEAYFAVPGMGAVLHTANPRL 106 Query: 108 QRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQDAI 167 E+ + E +L+ D + E +++ ++++ Sbjct: 107 SPKEIAYILNHAEDKVLLFDPNLLPL-----VEAIRGELKTVQHFVVMDEKAPEGYLAYE 161 Query: 168 NHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYS--VRRSVEICQFTQQTR 225 E+ P + GTTG PK + +H V+ +++ Sbjct: 162 EALGEEADPVRVPERAACGMAYTTGTTGLPKGVVYSHRALVLHSLAASLVDGTALSEKDV 221 Query: 226 YLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSL 285 L +P H A P + + V+ L + V TA VP Sbjct: 222 VLPVVPMFHVNAWCLPYA-ATLVGAKQVLPGPRLDPASLVELFDGEGVTFTAGVPTVWLA 280 Query: 286 WLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNY---- 341 L R L +L+ L VGG+ +L AR +G +++Q +G+ E Sbjct: 281 LADYLESTGHR--LKTLRRLVVGGSAAPRSLIARF-ERMGVEVRQGYGLTETSPVVVQNF 337 Query: 342 ------TRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQG--EVGRLMTRGPYTFRG 393 + ++ + G P+ P + VAD EG P+P+ +G + +GP+ G Sbjct: 338 VKSHLESLSEEEKLTLKAKTGLPI-PLVRLRVADEEGRPVPKDGKALGEVQLKGPWITGG 396 Query: 394 YYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLR 453 YY + + SA +GF+ +GD+ D EGY+ ++ R KD I GGE I++ ++EN L+ Sbjct: 397 YYGNEEATRSALTPDGFFRTGDIAVWDEEGYVEIKDRLKDLIKSGGEWISSVDLENALMG 456 Query: 454 HPAVIYAALVSMEDELMGEKSCAYLVVK-EPLRAVQVRRFLREQGIAEFKLPDRVECVDS 512 HP V AA+V++ E+ A +V + E ++ L + G A+++LPD + Sbjct: 457 HPKVKEAAVVAIPHPKWQERPLAVVVPRGEKPTPEELNEHLLKAGFAKWQLPDAYVFAEE 516 Query: 513 LPLTAVGKVDKKQLRQW 529 +P T+ GK K+ LR+ Sbjct: 517 IPRTSAGKFLKRALREQ 533 >4GR5-A nrPDB Length = 570 Score = 345 bits (886), Expect = 2e-95, Method: Composition-based stats. Identities = 117/508 (23%), Positives = 194/508 (38%), Gaps = 47/508 (9%) Query: 36 ASDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLK 95 A D++A++ +L+Y LN+ A+ LA L G+ PG V L ++ + A+LK Sbjct: 88 APDAVALLHEADELTYGALNERANRLAHRLVGLGVAPGTLVGVHLERGFDMVVALLAVLK 147 Query: 96 LGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLL 155 G + L LL+ R L+ +T +++ V Sbjct: 148 AGGGYTMLDPQFPVERLALSLEDTGAPLLVTSRP---------LSGRLTGTTTLYVED-- 196 Query: 156 NDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSV 215 + A + PA + P ++VA + G+TG PK + H Sbjct: 197 --------EAASDAPAGNLATGVGP-EDVACVMFTSGSTGRPKGVMSPHRAL-TGTYLGQ 246 Query: 216 EICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAA--DPSATLCFPLIEKHQV 273 + F +L P ++ G L G VL + +P L+ +H V Sbjct: 247 DYAGFGPDEVFLQCSPV--SWDAFGLELFGALLFGARCVLQSGQNPDPLEIGELVARHGV 304 Query: 274 NVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPA-EIGCQLQQVF 332 + L + + + E ++ GG S A+ +L + Sbjct: 305 TMLQLSASLFNFLVDEVPEA-----FEGVRYAITGGEPASVPHVAKARRDHPALRLGNGY 359 Query: 333 GMAEGLVNYTRLDDSAEKIIH---TQGYPMCPDDEVWVADAEGNPLPQGEVGRLMTRGPY 389 G AE + T A + G P+ +V D + P G +G L G Sbjct: 360 GPAESMGFTTHHAVVAGDLSGTALPIGVPLA-GKRAYVLDDDLKPAANGALGELYVAGAG 418 Query: 390 TFRGYYKSPQHNASAFDANGF--------YCSGDLISIDPEGYITVQGREKDQINRGGEK 441 GY P A F A+ F Y +GDL +G + GR DQ+ G + Sbjct: 419 LAHGYVSRPALTAERFVADPFAGPGGERMYRTGDLARRRADGVLEYVGRADDQVKIRGFR 478 Query: 442 IAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKE---PLRAVQVRRFLREQGI 498 + E+E L+ HPAV AA+++ + L ++ AY+V + P A ++RR + E + Sbjct: 479 VEPGEVEARLVGHPAVRQAAVLAQDSRLGDKQLVAYVVAERADAPPDAAELRRHVAE-AL 537 Query: 499 AEFKLPDRVECVDSLPLTAVGKVDKKQL 526 + +P VD LP T GK+D++ L Sbjct: 538 PAYMVPVECVPVDELPRTPNGKLDRRAL 565 >3L8C-A nrPDB Length = 521 Score = 341 bits (874), Expect = 6e-94, Method: Composition-based stats. Identities = 106/510 (20%), Positives = 202/510 (39%), Gaps = 44/510 (8%) Query: 45 GERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLAL 104 GER+ +Y +L + +D++A + + LV ++ TF AL K G A + Sbjct: 27 GERR-TYGQLKRDSDSIAAFIDSLALLAKSPVLVFGAQTYDMLATFVALTKSGHAYIPVD 85 Query: 105 FSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQ 164 + A +P+L+IA + L ++ ++ ++ Sbjct: 86 VHSAPERILAIIEIAKPSLIIAIEEFPL------------------TIEGISLVSLSEIE 127 Query: 165 DAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFT--Q 222 A D+ Y + GTTG PK + +H++ +E F + Sbjct: 128 SAKLAEMPYERTHSVKGDDNYYIIFTSGTTGQPKGVQISHDNLLSFTNWMIEDAAFDVPK 187 Query: 223 QTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADP---SATLCFPLIEKHQVNVTALV 279 Q + L P +++ +S GGT+ F I + V + Sbjct: 188 QPQMLAQPP--YSFDLSVMYWAPTLALGGTLFALPKELVADFKQLFTTIAQLPVGIWTST 245 Query: 280 PPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIG-CQLQQVFGMAEGL 338 P + + L + +A++ +L G L+ + A ++ ++ +G E Sbjct: 246 PSFADMAM--LSDDFCQAKMPALTHFYFDGEELTVSTARKLFERFPSAKIINAYGPTEAT 303 Query: 339 VNYTRLDDSAEKIIHTQGYPMC---PDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYY 395 V + ++ + E + + P+ PD ++ D +G L GE G ++ GP +GY Sbjct: 304 VALSAIEITREMVDNYTRLPIGYPKPDSPTYIIDEDGKELSSGEQGEIIVTGPAVSKGYL 363 Query: 396 KSPQHNAS---AFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLL 452 +P+ A F Y +GD+ S+ + + GR QI G +I E++ L Sbjct: 364 NNPEKTAEAFFTFKGQPAYHTGDIGSLTEDNILLYGGRLDFQIKYAGYRIELEDVSQQLN 423 Query: 453 RHPAVIYAALVS-MEDELMGEKSCAYLVVKEPLR-----AVQVRRFLR---EQGIAEFKL 503 + P V A V E + AY+VVK+ ++ +++ + ++ + + + + Sbjct: 424 QSPMVASAVAVPRYNKEHKVQNLLAYIVVKDGVKERFDRELELTKAIKASVKDHMMSYMM 483 Query: 504 PDRVECVDSLPLTAVGKVDKKQLRQWLASR 533 P + DSLPLT GK+D K L + +R Sbjct: 484 PSKFLYRDSLPLTPNGKIDIKTLINEVNNR 513 >4R0M-B nrPDB Length = 643 Score = 320 bits (820), Expect = 9e-88, Method: Composition-based stats. Identities = 124/520 (23%), Positives = 217/520 (41%), Gaps = 37/520 (7%) Query: 34 HAASDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFAL 93 + +D+ SY++L Q A + L ++GIK G ++Q+ + +A Sbjct: 36 YIRNDATEYFQ-----SYQDLYQDALVILNGLEQKGIKLGHKVILQIAKNQDFIPALWAC 90 Query: 94 LKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQ 153 G+ PV + N+ ++E I D + L D L T + + + ++ Sbjct: 91 FLGGIIPVPLTVAPSYDLENSAVKKLENVWKILD--NPLILSDSELITEIEKLGTYSHLE 148 Query: 154 LLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRR 213 + L+ A + + P + A + G+TG PK + TH++ Sbjct: 149 GWQVISVNELRKAPSKIEQLPILDPQ---DAALLLFTSGSTGMPKGVILTHHNILSMTAG 205 Query: 214 SVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAAD---PSATLCFPLIEK 270 +V + FTQQ L +P H A+ G + V LA + + + LI+K Sbjct: 206 TVVMNHFTQQEVTLNWMPLDHVGAIVFLGIMAVDLACDQIHVPMELVLRQPLQWLELIQK 265 Query: 271 HQVNVTALVPPAVSLWLQALIEGES-RAQLASLKLLQVGGARLSATLAARIPAEI-GCQL 328 HQV+++ A SL Q E + L+S+K L G ++S + QL Sbjct: 266 HQVSISWSPNFAFSLINQQAEELKHVSYNLSSMKFLVNAGEQVSVKTIRLFLEILEKHQL 325 Query: 329 QQV-----FGMAEGLVNYTR------LDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQ 377 Q+ FGM E T + + E + G P+ P + + D E NPLP+ Sbjct: 326 QERAIKPAFGMTESCSGITWSAGLSKNELTEENSFVSLGKPI-PGATIRIVDQENNPLPE 384 Query: 378 GEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINR 437 E+GRL +G +GYY + + N F G++ +GDL + G + + GREK +I Sbjct: 385 REIGRLQIQGNSVTKGYYNNNELNQEVFQ-EGWFTTGDLGYLSK-GELFITGREKQEIII 442 Query: 438 GGEKIAAEEIENLLLRHPA--VIYAALVSMEDELMGEKSCAYL---VVKEPLRAVQVRRF 492 G A E+E + V Y A ++ D+ ++ + ++V R Sbjct: 443 NGVNYFAHELETTIEELEGVKVSYTAAFAVFDQSRETDLLIITFSPESEQFEQGIKVVRK 502 Query: 493 LREQGIAEFKL-PDRVECVDS--LPLTAVGKVDKKQLRQW 529 +R +F + P V ++ +P T++GKV K +L++ Sbjct: 503 IRSHVTQKFGIAPAYVIPLERNLVPKTSIGKVQKSKLKKD 542 >3PBK-A nrPDB Length = 583 Score = 318 bits (816), Expect = 3e-87, Method: Composition-based stats. Identities = 113/572 (19%), Positives = 223/572 (38%), Gaps = 76/572 (13%) Query: 13 ARRYREKGYWQDLP-LTDILTRHAASDS-IAVIDG----ERQLSYRELNQAADNLACSLR 66 + + D P L D L A S + + D E QL Y+ L A+ A L Sbjct: 7 IFTHSLPMRYADFPTLVDALDYAALSSAGMNFYDRRCQLEDQLEYQTLKARAEAGAKRLL 66 Query: 67 RQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIA 126 +K G+ + +E FFA G+ V + ++++++++ LL + Sbjct: 67 SLNLKKGDRVALIAETSSEFVEAFFACQYAGLVAVPLAIPMGVGQRDSWSAKLQ-GLLAS 125 Query: 127 DRQHALFSGDDFL---NTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPADE 183 + A+ +GD++L N ++ + V+ H A+ P D ++ Sbjct: 126 CQPAAIITGDEWLPLVNAATHDNPELHVLS-------HAWFKAL--PEADVALQRPVPND 176 Query: 184 VAYFQLSGGTTGTPKLIPRTHNDYYYSVRR-SVEICQFTQQTRYLCAIPAAHNYAMSSPG 242 +AY Q + G+T P+ + TH + ++R S + + R + +P H+ + Sbjct: 177 IAYLQYTSGSTRFPRGVIITHREVMANLRAISHDGIKLRPGDRCVSWLPFYHDMGL---- 232 Query: 243 SLGVFLAGGTVVLAADP--------SATLCFPLIEKHQVNVTALVPPAVSLWLQALIE-G 293 +G L L+ D LI K++ V+ P L + + E Sbjct: 233 -VGFLLTPVATQLSVDYLRTQDFAMRPLQWLKLISKNRGTVSVAPPFGYELCQRRVNEKD 291 Query: 294 ESRAQLASLKLLQVGGARLSATLAARIPAEI------GCQLQQVFGMAEGLVNYTRLDDS 347 + L+ ++ +G +SA + +G+AE + + D++ Sbjct: 292 LAELDLSCWRVAGIGAEPISAEQLHQFAECFRQVNFDNKTFMPCYGLAENALAVSFSDEA 351 Query: 348 A--------EKIIHTQGYPMCPDDE------------------VWVADAEGNPLPQGEVG 381 + I+ QG + P E + + + G P+ + VG Sbjct: 352 SGVVVNEVDRDILEYQGKAVAPGAETRAVSTFVNCGKALPEHGIEIRNEAGMPVAERVVG 411 Query: 382 RLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGEK 441 + GP GY+ Q + A G+ +GDL + +GY+ V GR KD I G Sbjct: 412 HICISGPSLMSGYFGD-QVSQDEIAATGWLDTGDLGYLL-DGYLYVTGRIKDLIIIRGRN 469 Query: 442 IAAEEIENLLLRHPAVIYA---ALVSMEDELMGEKSCAYLVVKEPLRAVQVRRFLREQGI 498 I ++IE + + P + A V+ +++++ + C + + R Q+ L + Sbjct: 470 IWPQDIEYIAEQEPEIHSGDAIAFVTAQEKIILQIQCR---ISDEERRGQLIHALAARIQ 526 Query: 499 AEFKLPDRVECVD--SLPLTAVGKVDKKQLRQ 528 +EF + ++ + S+P T+ GK + + ++ Sbjct: 527 SEFGVTAAIDLLPPHSIPRTSSGKPARAEAKK 558 >5WMM-A nrPDB Length = 926 Score = 315 bits (807), Expect = 3e-86, Method: Composition-based stats. Identities = 96/467 (20%), Positives = 160/467 (34%), Gaps = 55/467 (11%) Query: 36 ASDSIAVI--DGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFAL 93 +++A++ DGE +Y EL++ A+ +A L +G+ + + L Sbjct: 67 QPEAVALVAADGEESWTYGELDRWANRIAHHLHARGVGRQHRVALVMERSPLLVAAVLGT 126 Query: 94 LKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQ 153 LK G V + R+ ++ + ++PAL+I +R Sbjct: 127 LKAGACYVPVEPTWPRARIDLVLADLDPALVIDERLA----------------------- 163 Query: 154 LLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRR 213 +D +P + +AY + G+TGTPK + +H + Sbjct: 164 ---------EEDLTGYPTRPLDTADVGGEHLAYLMYTSGSTGTPKGVEVSHRNVLSLALD 214 Query: 214 SVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAA-DPSATLCFPLIEKHQ 272 R L P + + + + G VV A LI + Sbjct: 215 P--CWADADHQRVLVHAPPTFDASTYEMW-VPLLHGGAAVVAPPGKLDAARLATLIAERG 271 Query: 273 VNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPAEIG-CQLQQV 331 V L L LI ++ + GG LS R+ + G + Sbjct: 272 VTALWLP-----AGLFDLITQHHPKSFVQVREVWAGGDVLSPAAVRRLVRDDGTLTVVNG 326 Query: 332 FGMAEGLVNYTRLDDSAE---KIIHTQGYPMCPDDEVWVADAEGNPLPQGEVGRLMTRGP 388 +G E R SA K G PM ++ D +PQG +G L G Sbjct: 327 YGPTETTTFAARYRMSAPARCKDPLPIGEPMA-GSRLYALDDRLRQVPQGVIGELYVGGD 385 Query: 389 YTFRGYYKSPQHNASAF-------DANGFYCSGDLISIDPEGYITVQGREKDQINRGGEK 441 RGY P + F Y +GDL+ + +G + GR +Q+ G + Sbjct: 386 GVARGYANHPPLTSERFVADPFGRPGERMYRTGDLVRWNHDGQLEFLGRVDEQVKIRGFR 445 Query: 442 IAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKEPLRAVQ 488 + EI L + V A +V D L + AY+V + P A + Sbjct: 446 VEPGEIRAALRKRDGVAQAVVVPRTDRLGERRLVAYVVPEVPAGADE 492 Score = 37.0 bits (84), Expect = 0.020, Method: Composition-based stats. Identities = 17/86 (19%), Positives = 37/86 (43%), Gaps = 12/86 (13%) Query: 455 PAVIYAALVSMED--------ELMGEKSCAYL-VVKEPLRAVQVRRFLREQ---GIAEFK 502 P A ++ ++ +G + + + R ++ +LRE+ + E Sbjct: 839 PGWFEAVIIPVDSGHCRDGVYRPVGPRPRQLVNLPAAARRVSRLPSWLREELAAELPEHL 898 Query: 503 LPDRVECVDSLPLTAVGKVDKKQLRQ 528 +P + ++ LPLT GK+D +L + Sbjct: 899 VPGDIVVMERLPLTTNGKIDHSRLPE 924 >3LNV-A nrPDB Length = 590 Score = 305 bits (782), Expect = 2e-83, Method: Composition-based stats. Identities = 110/581 (18%), Positives = 212/581 (36%), Gaps = 79/581 (13%) Query: 18 EKGYWQDLPLTDILTRHA----ASDSIAVIDGE--RQLSYRELNQAADNLACSLRRQGIK 71 +K Y Q L D++ A S ++ E ++Y +L+Q A +A +L+ +G K Sbjct: 4 KKEYLQCQSLVDVVRLRALHSPNKKSCTFLNKELEETMTYEQLDQHAKAIAATLQAEGAK 63 Query: 72 PGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQI----EPALLIAD 127 PG+ L+ L F L G V ++ + +L A +I +P +++ Sbjct: 64 PGDRVLLLFAPGLPLIQAFLGCLYAGCIAVP-IYPPAQEKLLDKAQRIVTNSKPVIVLMI 122 Query: 128 RQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYF 187 H D LNT +++ + +S E N + + T ++++A+ Sbjct: 123 ADHIKKFTADELNT---NPKFLKIPAIALESIELNRSSS-------WQPTSIKSNDIAFL 172 Query: 188 QLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVF 247 Q + G+T PK + +H++ ++ + +T +P H+ + G + Sbjct: 173 QYTSGSTMHPKGVMVSHHNLLDNLNKIFTSFHMNDETIIFSWLPPHHDMGL--IGCILTP 230 Query: 248 LAGGTVVLAADPSATLCFPL-----IEKHQVNVTALVPPAVSLWLQALIEGESRAQLASL 302 + GG + P + L PL I K++ ++ A ++ + E + S Sbjct: 231 IYGGIQAIMMSPFSFLQNPLSWLKHITKYKATISGSPNFAYDYCVKRIREEKKEGLDLSS 290 Query: 303 KLLQVGGA--RLSATLAARIPA--EIGCQ---LQQVFGMAEGLVNYTRLDDSAEKIIHTQ 355 + GA T+ A E G + +G+AE + T + T Sbjct: 291 WVTAFNGAEPVREETMEHFYQAFKEFGFRKEAFYPCYGLAEATLLVTGGTPGSSYKTLTL 350 Query: 356 GYPMCPDDEVWVADA----------EGNPLPQ--------------GEVGRLMTRGPYTF 391 D V AD GNP+ + +VG + + Sbjct: 351 AKEQFQDHRVHFADDNSPGSYKLVSSGNPIQEVKIIDPDTLIPCDFDQVGEIWVQSNSVA 410 Query: 392 RGYYKSPQHNASAFDAN--------GFYCSGDLISIDPEGYITVQGREKDQINRGGEKIA 443 +GY+ P+ AF + +GDL + + V GR KD I G+ Sbjct: 411 KGYWNQPEETRHAFAGKIKDDERSAIYLRTGDLGFLHEN-ELYVTGRIKDLIIIYGKNHY 469 Query: 444 AEEIENLLLRHPA---VIYAALVSMEDELMGEKSCAYLVVKEPLRAV-------QVRRFL 493 ++IE L+ P + A +++E + + V + V ++ + Sbjct: 470 PQDIEFSLMHSPLHHVLGKCAAFVIQEEHEYKLTVMCEVKNRFMDDVAQDNLFNEIFELV 529 Query: 494 REQGIAEFKLPDRVECVDSLPLTAVGKVDKKQLRQWLASRA 534 E E + + ++P T GK+ + R+ L + Sbjct: 530 YENHQLEVHTIV-LIPLKAMPHTTSGKIRRNFCRKHLLDKT 569 >6NJ0-A nrPDB Length = 451 Score = 302 bits (774), Expect = 2e-82, Method: Composition-based stats. Identities = 101/510 (19%), Positives = 191/510 (37%), Gaps = 64/510 (12%) Query: 21 YWQDLPLTDILTRHAASDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQL 80 + D P R ++IA+ + QL++REL D LA QG+ G +++ Sbjct: 2 IFSDWPWRHW--RQVRGETIALRLNDEQLNWRELCARVDELASGFAVQGVVEGSGVMLRA 59 Query: 81 GNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLN 140 N + + + ALL+ G + + L + + F Sbjct: 60 WNTPQTLLAWLALLQCGARVLPVNPQLPQPLLEELLPNLTLQFALVPDGENTF------- 112 Query: 141 TFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLI 200 ++ + + G H AT P + L+ G+TG PK Sbjct: 113 ------PALTSLHIQLVEGAH-------------AATWQPT-RLCSMTLTSGSTGLPKAA 152 Query: 201 PRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPS 260 T+ + S + + + F +L ++P H S G + +L G + D Sbjct: 153 VHTYQAHLASAQGVLSLIPFGDHDDWLLSLPLFHV---SGQGIMWRWLYAGARMTVRDKQ 209 Query: 261 ATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARI 320 ++ +LVP + L SLK + +GGA + L + Sbjct: 210 PLE--QMLA--GCTHASLVPTQLWRLLVNRSS-------VSLKAVLLGGAAIPVELTEQ- 257 Query: 321 PAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEV 380 E G + +G+ E + + G P+ P EV + + Sbjct: 258 AREQGIRCFCGYGLTEFASTVCAKEADG---LADVGSPL-PGREVKIVNN---------- 303 Query: 381 GRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQGREKDQINRGGE 440 + R GY+++ Q S + G+Y + D + G +T+ GR + GGE Sbjct: 304 -EVWLRAASMAEGYWRNGQL-VSLVNDEGWYATRDRGEMH-NGKLTIVGRLDNLFFSGGE 360 Query: 441 KIAAEEIENLLLRHPAVIYAALVSMEDELMGEKSCAYLVVKEPLRAVQVRRFLREQGIAE 500 I EE+E ++ HPAV+ +V + D+ G + A V++ +V + +++++ +A Sbjct: 361 GIQPEEVERVIAAHPAVLQVFIVPVADKEFGHRPVA--VMEYDHESVDLSEWVKDK-LAR 417 Query: 501 FKLPDRVECVDSLPLTAVGKVDKKQLRQWL 530 F+ P R + K+ ++ L++W+ Sbjct: 418 FQQPVRWLTLPPELKNGGIKISRQALKEWV 447 >5JNF-C nrPDB Length = 587 Score = 288 bits (736), Expect = 5e-78, Method: Composition-based stats. Identities = 82/421 (19%), Positives = 149/421 (35%), Gaps = 47/421 (11%) Query: 23 QDLPLTDILTRHAA--SDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQL 80 D + + D +AV+D + L+Y++LN+ A+ LA LR +G+KP + + L Sbjct: 203 IDKTFHQLFEQQVEMTPDHVAVVDRGQSLTYKQLNERANQLAHHLRGKGVKPDDQVAIML 262 Query: 81 GNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLN 140 ++ ++ A++K G A V + + + A+L+ + Sbjct: 263 DKSLDMIVSILAVMKAGGAYVPIDPDYPGERIAYMLADSSAAILLTN------------- 309 Query: 141 TFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLI 200 + E + +++ + + N+ + D++ Y + G+TG K + Sbjct: 310 -ALHEEKANGACDIIDVHDPDSYSENTNN-----LPHVNRPDDLVYVMYTSGSTGLAKGV 363 Query: 201 PRTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPS 260 H++ V C++ + Y PA SS G L T +LA + Sbjct: 364 MIEHHNL-------VNFCEWYRP--YFGVTPADKALVYSSFSFDGSALDIFTHLLAG--A 412 Query: 261 ATLCFPLIEKHQVNVTALVPPAVSLWLQALI----EGESRAQLASLKLLQVGGARLSATL 316 A P K+ ++ + + L E + S +++ GG L Sbjct: 413 ALHIVPSERKYDLDALNDYCNQEGITISYLPTGAAEQFMQMDNQSFRVVITGGDVL---- 468 Query: 317 AARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLP 376 +I +L +G E + T + G P+ + + D P Sbjct: 469 -KKIERNGTYKLYNGYGPTECTIMVTMFEVDKPYANIPIGKPI-DRTRILILDEALALQP 526 Query: 377 QGEVGRLMTRGPYTFRGYYKSPQHNASAF-----DANGFYCSGDLISIDPEGYITVQGRE 431 G G L G RGY P+ A F Y +GD P+G I GR Sbjct: 527 IGVAGELFIVGEGLGRGYLNRPELTAEKFIVHPQTGERMYRTGDRARFLPDGNIEFLGRL 586 Query: 432 K 432 Sbjct: 587 D 587 >4GR4-A nrPDB Length = 469 Score = 251 bits (640), Expect = 6e-67, Method: Composition-based stats. Identities = 86/411 (20%), Positives = 141/411 (34%), Gaps = 43/411 (10%) Query: 36 ASDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLK 95 A D++A++ +L+Y LN+ A+ LA L G+ PG V L ++ + A+LK Sbjct: 88 APDAVALLHEADELTYGALNERANRLAHRLVGLGVAPGTLVGVHLERGFDMVVALLAVLK 147 Query: 96 LGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLL 155 G + L LL+ R L+ +T +++ V Sbjct: 148 AGGGYTMLDPQFPVERLALSLEDTGAPLLVTSRP---------LSGRLTGTTTLYVED-- 196 Query: 156 NDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSV 215 + A + PA + P ++VA + G+TG PK + H Sbjct: 197 --------EAASDAPAGNLATGVGP-EDVACVMFTSGSTGRPKGVMSPHRAL-TGTYLGQ 246 Query: 216 EICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAA--DPSATLCFPLIEKHQV 273 + F +L P ++ G L G VL + +P L+ +H V Sbjct: 247 DYAGFGPDEVFLQCSPV--SWDAFGLELFGALLFGARCVLQSGQNPDPLEIGELVARHGV 304 Query: 274 NVTALVPPAVSLWLQALIEGESRAQLASLKLLQVGGARLSATLAARIPA-EIGCQLQQVF 332 + L + + + E ++ GG S A+ +L + Sbjct: 305 TMLQLSASLFNFLVDEVPEA-----FEGVRYAITGGEPASVPHVAKARRDHPALRLGNGY 359 Query: 333 GMAEGLVNYTRLDDSAEKIIH---TQGYPMCPDDEVWVADAEGNPLPQGEVGRLMTRGPY 389 G AE + T A + G P+ +V D + P G +G L G Sbjct: 360 GPAESMGFTTHHAVVAGDLSGTALPIGVPLA-GKRAYVLDDDLKPAANGALGELYVAGAG 418 Query: 390 TFRGYYKSPQHNASAFDANGF--------YCSGDLISIDPEGYITVQGREK 432 GY P A F A+ F Y +GDL +G + GR Sbjct: 419 LAHGYVSRPALTAERFVADPFAGPGGERMYRTGDLARRRADGVLEYVGRAD 469 >4WD1-A nrPDB Length = 658 Score = 230 bits (585), Expect = 1e-60, Method: Composition-based stats. Identities = 100/549 (18%), Positives = 187/549 (34%), Gaps = 46/549 (8%) Query: 19 KGYWQDLPLTDILTRHAASDSIAVIDGERQ-----LSYRELNQAADNLACSLRRQGIKPG 73 G + + D A++ + +++ EL + +LA LR G++PG Sbjct: 87 PGATLNYAEHALRAAGTRPDEPALLYVDETHEPAPVTWAELRRQVASLAAELRALGVRPG 146 Query: 74 ETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQ---- 129 + L N+ + + A +G + Q+EP +L Sbjct: 147 DRVSGYLPNIPQAVVALLATAAVGGVWTSCAPDFGARSVLDRFQQVEPVVLFTVDGYRYG 206 Query: 130 HALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQ-----DAINHPAEDFTATPSPADEV 184 D + E ++R V + G + + + P D Sbjct: 207 GKEHDRRDTVAELRRELPTLRAVIHIPLLGTEAPDGTLDWETLTAADAEPVYEQVPFDHP 266 Query: 185 AYFQLSGGTTGTPKLIPRTHNDYYY-SVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGS 243 + S GTTG PK I ++ +++ C R+ + M + Sbjct: 267 LWVLYSSGTTGLPKAIVQSQGGILVEHLKQLGLHCDLGPGDRFFWYTST--GWMMWNFLV 324 Query: 244 LGVFLAGGTVVL----AADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQL 299 G L G T+VL P+ + + E+ + V +A + L Sbjct: 325 SG-LLTGTTIVLYDGSPGFPATDAQWRIAERTGATLFGTSAAYVMACRKAGVHPARDLDL 383 Query: 300 ASLKLLQVGGARLSATLAARIPAEIGC-----QLQQVFGMAEGLVNYTRLDDSAEKIIHT 354 ++++ + G+ L + E + V G + + + I Sbjct: 384 SAIQCVATTGSPLPPDGFRWLHDEFAAGGADLWIASVSGGTDVCSCFAGAVPTLPVHIGE 443 Query: 355 QGYPMCPDDEVWVADAEGNPLPQGEVGRLMTR-----GPYTFRGYYKSPQHNASAFD-AN 408 P ++ D G+PL EVG L+ P F +++ S FD Sbjct: 444 LQAP-GLGTDLQSWDPSGDPL-TDEVGELVVTNPMPSMPIRFWNDPDGSRYHDSYFDTYP 501 Query: 409 GFYCSGDLISIDPEGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSMEDE 468 G + GD I++ G + + GR +NR G ++ + +I + R P + + ++ +E Sbjct: 502 GVWRHGDWITLTSRGSVVIHGRSDSTLNRQGVRMGSADIYEAVERLPEIRESLVIGIEQP 561 Query: 469 LMGEKSCAYLVVKEPLRA------VQVRRFLREQGIAEFKLPDRVECVDSLPLTAVGK-- 520 G V P +++R +R ++ +PD V V +P T GK Sbjct: 562 DGG-YWMPLFVHLAPGATLDDALLDRIKRTIRVN-LSPRHVPDEVIEVPGIPHTLTGKRI 619 Query: 521 -VDKKQLRQ 528 V K+L Q Sbjct: 620 EVPVKRLLQ 628 >5EY8-A nrPDB Length = 630 Score = 224 bits (570), Expect = 9e-59, Method: Composition-based stats. Identities = 90/591 (15%), Positives = 180/591 (30%), Gaps = 109/591 (18%) Query: 34 HAASDSIAVI--------DGE-RQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVA 84 D +A DG R L++ + + +A L++ +PG+ + Sbjct: 30 KVRGDKLAYRFLDFSTERDGVPRDLTWAQFSARNRAVAARLQQV-TQPGDRVAILCPQNL 88 Query: 85 ELYITFFALLKLGVAPVLALFSHQRS---ELNAYASQIEPALLIADRQHALFSGDDFLNT 141 + + FF L G V + L+A P+ ++ + A F Sbjct: 89 DYLVAFFGALYAGRIAVPLFDPSEPGHVGRLHAVLDNCHPSAILTTTEAAEGVRKFFRTR 148 Query: 142 FVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIP 201 + + V + D +N D T +AY Q + G+T P + Sbjct: 149 PANQRPRVIAVDAVPD---DVASTWVNPDEPDETT-------IAYLQYTSGSTRIPTGVQ 198 Query: 202 RTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADP-- 259 TH + +V + +E + + R L +P H+ + + + T + A Sbjct: 199 ITHLNLATNVVQVIEALEGEEGDRGLSWLPFFHDMGLITALLAPMIGHYFTFMTPAAFVR 258 Query: 260 SATLCFPLIEKH----QVNVTALVPPAVSLWLQALI--EGESRAQLASLKLLQVGGARLS 313 + + ++ A + G L+++K + G +S Sbjct: 259 RPERWIRELARKEGDTGGTISVAPNFAFDHAAARGVPKPGSPPLDLSNVKAVLNGSEPIS 318 Query: 314 ATLAARIPAEIGC------QLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWV 367 A R G ++ +G+AE + + + E I T + Sbjct: 319 AATVRRFNEAFGPFGFPPKAIKPSYGLAEATLFVSTTPSAEEPKIITVDRDQLNSGRIVE 378 Query: 368 AD--------------------------AEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHN 401 D LP G+VG + G GY+ P+ + Sbjct: 379 VDADSPKAVAQASAGKVGIAEWAVIVDAESATELPDGQVGEIWISGQNMGTGYWGKPEES 438 Query: 402 ASAFD-----------ANG------FYCSGDLISIDPEGYITVQGREKDQINRGGEKIAA 444 + F A G + +GD + +G + + GR KD + G Sbjct: 439 VATFQNILKSRTNPSHAEGATDDATWVRTGDYGAF-YDGDLYITGRVKDLVIIDGRNHYP 497 Query: 445 EEIENL-------------------LLRHP-AVIYAALVSMEDELMGEKSCAYLVVKEPL 484 +++E + P V A ++ + +V + Sbjct: 498 QDLEYSAQEASKAIRTGYVAAFSVPANQLPDEVFENAHSGIKRDPDDTSEQLVIVAERAP 557 Query: 485 RAVQV-----RRFLREQGIAEFKLPDRVECVD---SLPLTAVGKVDKKQLR 527 A ++ +R + R + ++P T+ GK+ ++ R Sbjct: 558 GAHKLDIGPITDDIRAAIAVRHGVTVRDVLLTAAGAIPRTSSGKIGRRACR 608 >5EY9-A nrPDB Length = 629 Score = 201 bits (512), Expect = 5e-52, Method: Composition-based stats. Identities = 91/592 (15%), Positives = 178/592 (30%), Gaps = 112/592 (18%) Query: 34 HAASDSIAVI--------DG-ERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVA 84 D +A DG ER + + E + + L++ +PG+ + Sbjct: 30 RVRGDKLAYRFLDFSTERDGVERDILWSEFSARNRAVGARLQQV-TQPGDRIAILCPQNL 88 Query: 85 ELYITFFALLKLGVAPVLALFSHQRS---ELNAYASQIEPALLIADRQHALFSGDDFLNT 141 + I+FF L G V + L+A P+ ++ A + Sbjct: 89 DYLISFFGALYSGRIAVPLFDPAEPGHVGRLHAVLDDCTPSTILTTTDSAEGVRKFIRSR 148 Query: 142 FVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIP 201 E + V + Q P + T AY Q + G+T P + Sbjct: 149 SAKERPRVIAVDAVPTEVASTWQQ----PEANELTT-------AYLQYTSGSTRVPSGVQ 197 Query: 202 RTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADP-- 259 TH + +V + + + + R + +P H+ + + V T + A Sbjct: 198 ITHLNLPTNVLQVLNALEGQEGDRGVSWLPFFHDMGLITVLLASVLGHSFTFMTPAAFVR 257 Query: 260 SATLCFPLIEKHQ----VNVTALVPPAVS--LWLQALIEGESRAQLASLKLLQVGGARLS 313 + + +A A + E L+++K + G +S Sbjct: 258 RPGRWIRELARKPGETGGTFSAAPNFAFEHAAMRGVPRDDEPPLDLSNVKGILNGSEPVS 317 Query: 314 ATLAARIPAEIGC------QLQQVFGMAEGLVNYTRLDDSAEKIIH-------------- 353 + ++ +G+AE + + + Sbjct: 318 PASMRKFFKAFEPYGLRETAVKPSYGLAEATLFVSTTPMDEVPTVIHVDRDELNKQRFVE 377 Query: 354 ------------TQGYPMCPDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHN 401 + G + V V + LP G++G + G GY+ + + Sbjct: 378 VAADAPNAVAQVSAGKVGVDEWAVIVDTETASELPDGQIGEIWLHGNNLGIGYWGKEEES 437 Query: 402 ASAF----------------DANG-FYCSGDLISIDPEGYITVQGREKDQINRGGEKIAA 444 A F +G + +GD + +G++ + GR KD + G Sbjct: 438 AQTFRNILKSRVPESHAEGAPDDGLWVRTGDYGTY-FKGHLYIAGRIKDLVIIDGRNHYP 496 Query: 445 EEIENLLLRHPA---VIYAALVSMEDELMGEK----SCAYLVVKEPLRAVQVRRFLREQG 497 +++E V Y A S+ + +K A L + Q+ + E+ Sbjct: 497 QDLEYTAQESTKALRVGYVAAFSVPANQLPQKVFDDPHAGLSFDPEDTSEQLV-IVGERA 555 Query: 498 IAEFKL---P-----------------DRVECVDS--LPLTAVGKVDKKQLR 527 KL P V V + +P T+ GK+ ++ R Sbjct: 556 AGTHKLEYQPIADDIRAAIAVGHGVTVRDVLLVSAGTIPRTSSGKIGRRACR 607 >5HM3-A nrPDB Length = 657 Score = 198 bits (502), Expect = 8e-51, Method: Composition-based stats. Identities = 88/592 (14%), Positives = 176/592 (29%), Gaps = 112/592 (18%) Query: 34 HAASDSIAVI--------DG-ERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVA 84 D +A DG R + + + + + L++ +PG+ + Sbjct: 58 KVRGDKLAYRFLDFSTERDGVARDILWSDFSARNRAVGARLQQV-TQPGDRVAILCPQNL 116 Query: 85 ELYITFFALLKLGVAPVLALFSHQRS---ELNAYASQIEPALLIADRQHALFSGDDFLNT 141 + I+FF L G V + L+A P+ ++ A Sbjct: 117 DYLISFFGALYSGRIAVPLFDPAEPGHVGRLHAVLDDCAPSTILTTTDSAEGVRKFIRAR 176 Query: 142 FVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIP 201 E + V + A + + + VAY Q + G+T P + Sbjct: 177 SAKERPRVIAVDAVPTEV-----------AATWQQPEANEETVAYLQYTSGSTRIPSGVQ 225 Query: 202 RTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADP-- 259 TH + +V + + + + R + +P H+ + + V T + A Sbjct: 226 ITHLNLPTNVVQVLNALEGQEGDRGVSWLPFFHDMGLITVLLASVLGHSFTFMTPAAFVR 285 Query: 260 SATLCFPLIEKHQ----VNVTALVPPAVS--LWLQALIEGESRAQLASLKLLQVGGARLS 313 + + +A A + E L+++K + G +S Sbjct: 286 RPGRWIRELARKPGETGGTFSAAPNFAFEHAAVRGVPRDDEPPLDLSNVKGILNGSEPVS 345 Query: 314 ATLAARIPAEI------GCQLQQVFGMAEGLVNYTRLDDSAEKIIH-------------- 353 + ++ +G+AE + + + Sbjct: 346 PASMRKFFEAFAPYGLKQTAVKPSYGLAEATLFVSTTPMDEVPTVIHVDRDELNNQRFVE 405 Query: 354 ------------TQGYPMCPDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHN 401 + G + V V + LP G++G + G GY+ + + Sbjct: 406 VAADAPNAVAQVSAGKVGVSEWAVIVDADTASELPDGQIGEIWLHGNNLGTGYWGKEEES 465 Query: 402 ASAF-----------DANG------FYCSGDLISIDPEGYITVQGREKDQINRGGEKIAA 444 A F A G + +GD + + ++ + GR KD + G Sbjct: 466 AQTFKNILKSRISESRAEGAPDDALWVRTGDYGTYFKD-HLYIAGRIKDLVIIDGRNHYP 524 Query: 445 EEIENLLLRHPA---VIYAALVSMEDELMGEKS----CAYLVVKEPLRAVQVRRFLREQG 497 +++E V YAA S+ + + A L + Q+ + E+ Sbjct: 525 QDLECTAQESTKALRVGYAAAFSVPANQLPQTVFDDSHAGLKFDPEDTSEQLV-IVGERA 583 Query: 498 IAEFKL---P-----------------DRVECVDS--LPLTAVGKVDKKQLR 527 KL P V V + +P T+ GK+ ++ R Sbjct: 584 AGTHKLDHQPIVDDIRAAIAVGHGVTVRDVLLVSAGTIPRTSSGKIGRRACR 635 >5D6N-A nrPDB Length = 508 Score = 192 bits (488), Expect = 3e-49, Method: Composition-based stats. Identities = 74/467 (15%), Positives = 143/467 (30%), Gaps = 81/467 (17%) Query: 34 HAASDSIAVI--------DGE-RQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVA 84 D +A DG R L++ + + +A L++ +PG+ + Sbjct: 54 KVRGDKLAYRFLDFSTERDGVPRDLTWAQFSARNRAVAARLQQV-TQPGDRVAILCPQNL 112 Query: 85 ELYITFFALLKLGVAPVLALFSHQRS---ELNAYASQIEPALLIADRQHALFSGDDFLNT 141 + + FF L G V + L+A P+ ++ + A F Sbjct: 113 DYLVAFFGALYAGRIAVPLFDPSEPGHVGRLHAVLDNCHPSAILTTTEAAEGVRKFFRTR 172 Query: 142 FVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIP 201 + + V + D +N D T +AY Q + G+T P + Sbjct: 173 PANQRPRVIAVDAVPD---DVASTWVNPDEPDETT-------IAYLQYTSGSTRIPTGVQ 222 Query: 202 RTHNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADP-- 259 TH + +V + +E + + R L +P H+ + + + T + A Sbjct: 223 ITHLNLATNVVQVIEALEGEEGDRGLSWLPFFHDMGLITALLAPMIGHYFTFMTPAAFVR 282 Query: 260 SATLCFPLIEKH----QVNVTALVPPAVSLWLQALI--EGESRAQLASLKLLQVGGARLS 313 + + ++ A + G L+++K + G +S Sbjct: 283 RPERWIRELARKEGDTGGTISVAPNFAFDHAAARGVPKPGSPPLDLSNVKAVLNGSEPIS 342 Query: 314 ATLAARIPAEIGC------QLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWV 367 A R G ++ +G+AE + + + E I T + Sbjct: 343 AATVRRFNEAFGPFGFPPKAIKPSYGLAEATLFVSTTPSAEEPKIITVDRDQLNSGRIVE 402 Query: 368 AD--------------------------AEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHN 401 D LP G+VG + G GY+ P+ + Sbjct: 403 VDADSPKAVAQASAGKVGIAEWAVIVDAESATELPDGQVGEIWISGQNMGTGYWGKPEES 462 Query: 402 ASAFD-----------ANG------FYCSGDLISIDPEGYITVQGRE 431 + F A G + +GD + +G + + GR Sbjct: 463 VATFQNILKSRTNPSHAEGATDDATWVRTGDYGAF-YDGDLYITGRV 508 >3E53-A nrPDB Length = 480 Score = 161 bits (408), Expect = 6e-40, Method: Composition-based stats. Identities = 67/437 (15%), Positives = 132/437 (30%), Gaps = 68/437 (15%) Query: 48 QLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSH 107 L++ +L + N+A L R G G+ ++ E + F L+ G V Sbjct: 58 TLTWSQLYRRTLNVAQELSRCG-STGDRVVISAPQGLEYVVAFLGALQAGRIAVPLSVPQ 116 Query: 108 ---QRSELNAYASQIEPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQ 164 ++ S P ++ DD + + D + + Sbjct: 117 GGVTDERSDSVLSDSSPVAILTTSSAV----DDVVQHVARRPGESPPSIIEVDLLDLDAP 172 Query: 165 DAINHPAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQFT--- 221 + +++ +T AY Q + G+T TP + +H + + + + Sbjct: 173 NGYTFKEDEYPST-------AYLQYTSGSTRTPAGVVMSHQNVRVNFEQLMSGYFADTDG 225 Query: 222 ---QQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVLAADPSATLC---FPLIEKHQVNV 275 + + +P H+ + G L G VL + S + + + Sbjct: 226 IPPPNSALVSWLPFYHDMGL-VIGICAPILGGYPAVLTSPVSFLQRPARWMHLMASDFHA 284 Query: 276 TALVPPAVSLWLQALIEGESRA--QLASLKLLQVGGARLSATLAARIP---AEIGCQ--- 327 + P + A L ++ + G R+ A R A Q Sbjct: 285 FSAAPNFAFELAARRTTDDDMAGRDLGNILTILSGSERVQAATIKRFADRFARFNLQERV 344 Query: 328 LQQVFGMAEGLVNYTR---------LDDSAEKIIHTQGYPMCPDDE-------------V 365 ++ +G+AE V +D E + P V Sbjct: 345 IRPSYGLAEATVYVATSKPGQPPETVDFDTESLSAGHAKPCAGGGATSLISYMLPRSPIV 404 Query: 366 WVADAEG-NPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAF-----------DANGFYCS 413 + D++ P G VG + G GY++ P + F + + Sbjct: 405 RIVDSDTCIECPDGTVGEIWVHGDNVANGYWQKPDESERTFGGKIVTPSPGTPEGPWLRT 464 Query: 414 GDLISIDPEGYITVQGR 430 GD + +G + + GR Sbjct: 465 GDSGFVT-DGKMFIIGR 480 >4RVO-A nrPDB Length = 436 Score = 116 bits (291), Expect = 2e-26, Method: Composition-based stats. Identities = 69/368 (18%), Positives = 123/368 (33%), Gaps = 42/368 (11%) Query: 183 EVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQF--TQQTRYLCAIPAAHNYAMSS 240 + S GTTG P +I + +D ++T + Sbjct: 87 DGVRIHSSSGTTGNPTVIVHSQHDLDSWANLVARCLYMVGIRKTDVFQNSSGYGMFTGGL 146 Query: 241 PGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQLA 300 G G V AA ++ I + +P + E + Sbjct: 147 GFQYGAERLGCLTVPAAAGNSKRQIKFISDFKTTALHAIPSYAIRLAEVFQEEGIDPRET 206 Query: 301 SLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPMC 360 +LK L +G + +I + + FGM E + + +H + C Sbjct: 207 TLKTLVIGAEPHTDEQRRKIERMLNVKAYNSFGMTEMNGPGVAFECQEQNGMHF--WEDC 264 Query: 361 PDDEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGF----YCSGDL 416 E+ + G P+P+GE+G L+ D Y + DL Sbjct: 265 YLVEI-IDPETGEPVPEGEIGELVLT-----------------TLDREMMPLIRYRTRDL 306 Query: 417 ISIDP------EGYI---TVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVSME- 466 I P ++ ++GR D G I ++E +L++ P + L+++E Sbjct: 307 TRILPGKCPCGRTHLRIDRIKGRSDDMFIIKGVNIFPMQVEKILVQFPELGSNYLITLET 366 Query: 467 ----DELMGEKSCAYLVVKEPLRAVQVRRFLREQGIAEFKLPDRVECVD--SLPLTAVGK 520 DE++ E + L + ++RR + Q E + +V+ V SLP + Sbjct: 367 VNNQDEMIVEVELSDLSTDNYIELEKIRRDIIRQLKDEILVTPKVKLVKKGSLPQSEGKA 426 Query: 521 VDKKQLRQ 528 V K LR Sbjct: 427 VRVKDLRD 434 >2Y4O-A nrPDB Length = 443 Score = 99.4 bits (246), Expect = 4e-21, Method: Composition-based stats. Identities = 61/377 (16%), Positives = 123/377 (32%), Gaps = 44/377 (11%) Query: 178 PSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSVEICQF--TQQTRYLCAIPAAHN 235 P ++V S GTTG P ++ T D + + + L Sbjct: 88 AVPREQVVRVHASSGTTGKPTVVGYTARDIDTWANVTARSIRAAGGRPGDTLHNA---FG 144 Query: 236 YAMSSPGS---LGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIE 292 Y + + G G G VV + LI + + + P + + ++ Sbjct: 145 YGLFTGGLGIHYGAERLGCMVVPMSGGQTEKQVQLIRDFEPKIILVTPSYMLNLIDEMVR 204 Query: 293 GESRAQLASLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKII 352 +SLK+ G + L + +G ++G++E + E + Sbjct: 205 QGMDPAESSLKIGIFGAEPWTQALRNEVETRVGIDALDIYGLSE----VMGPGVACECVE 260 Query: 353 HTQGYPMCPDDEVW---VADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANG 409 G P+ +D + + G LP G G L+ A Sbjct: 261 TKDG-PVIWEDHFYPEIIDPVTGEVLPDGSQGELVFTS------------LTKEAMPVIR 307 Query: 410 FYCSGDLISIDP------EGYITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALV 463 Y + DL ++ P + GR D + G + +IE +++ P + + Sbjct: 308 -YRTRDLTALLPPTARAMRRLAKITGRSDDMLIVRGVNVFPSQIEEIVVALPLLSGQFQI 366 Query: 464 SMEDELMGEKSCAYLVVKEPLRA-------VQVRRFLREQGIAEFKLPDRVECVDS--LP 514 ++ + ++ + ++ A + R L+ + + V + + +P Sbjct: 367 TLSRDGHMDRLDLAVELRSEAAASVTDGERAALARELQHRIKTMVGVSSGVTVLAAGGIP 426 Query: 515 LTAVGKVDKKQLRQWLA 531 TA GK + R+ A Sbjct: 427 ATATGKARRVIDRRQAA 443 >2Y4N-A nrPDB Length = 437 Score = 98.7 bits (244), Expect = 6e-21, Method: Composition-based stats. Identities = 52/291 (17%), Positives = 95/291 (32%), Gaps = 37/291 (12%) Query: 178 PSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRR---SVEICQFTQQTRYLCAIPAAH 234 P D ++ S GTTG P ++ T D S+ + + ++ Sbjct: 86 AVPQDRISRIHASSGTTGKPTVVGYTAADIDTWANLVARSIRAAGARRGDKV----HVSY 141 Query: 235 NYAMSSPGS---LGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALI 291 Y + + G G AG TV+ LI+ + ++ + P + + Sbjct: 142 GYGLFTGGLGAHYGAERAGLTVIPFGGGQTEKQVQLIQDFRPDIIMVTPSYMLSIADEIE 201 Query: 292 EGESRAQLASLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKI 351 +SL++ G + + I +G ++G++E ++E + Sbjct: 202 RQGLDPVQSSLRIGIFGAEPWTNDMRVAIEQRMGIDAVDIYGLSE----VMGPGVASECV 257 Query: 352 IHTQGYPMCPD--DEVWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANG 409 G + D + G LP GE+G L+ A Sbjct: 258 ETKDGPTIWEDHFYPEIIDPETGEVLPDGELGELVFTS------------LTKEALPIIR 305 Query: 410 FYCSGDLISIDPEGYIT-------VQGREKDQINRGGEKIAAEEIENLLLR 453 Y + DL + P G + GR D + G + +IE LL+ Sbjct: 306 -YRTRDLTRLLP-GTARTMRRMEKITGRSDDMMIVRGVNVFPTQIEEQLLK 354 >6HIV-BC nrPDB Length = 523 Score = 94.0 bits (232), Expect = 2e-19, Method: Composition-based stats. Identities = 72/471 (15%), Positives = 139/471 (29%), Gaps = 77/471 (16%) Query: 20 GYWQDLPLTD-ILTRHAASDSIAVIDGERQLSYRELNQAADNLACSLRRQGIKPGETALV 78 GY+ ++ + AV + ++ ++ + ++ LA L + G++PG+ L Sbjct: 65 GYYVNIQSRKMYYKDFLRIEHQAV-----RWAFADIRKNSEALAHGLLQTGLRPGQRVLA 119 Query: 79 QLGNVAELYITFFALLKLGVA-PVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDD 137 E ++ A K+G V+ + +L Y ++ +P LIA + Sbjct: 120 IQPCNCETFVLQLACAKIGALLAVVPHHNISADKLRFYLNEFQPHHLIAREWIVVPEVKQ 179 Query: 138 FLNTFVTEHSSIRVVQLLNDSGEHNL---QDAINHPAEDFTATPSPADEVAYFQLSGGTT 194 + H + ++ + G ++ F D G T Sbjct: 180 GVLVERNMHFWDMIYNVIPELGLSYPGQRFQWVHSQEFFFLKKVVITDHNMNLL---GVT 236 Query: 195 GTPKL-----------------------------------------IPRTHNDYYYSVRR 213 K+ I +H + + Sbjct: 237 PMRKMLVWGPFSYYEQRLRRLSALLHPDDPILALEDPHPALEDKLHITYSHRNCINAGFL 296 Query: 214 SVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTVVL---AADPSATLCFPLIEK 270 + ++R +P H + + + L G V++ + + IEK Sbjct: 297 FGNLMGLKAESR-FGVMPNHHVDPVGAIVAPYAALTTGAVLVHIHSDMFTDDHAINGIEK 355 Query: 271 ---HQVNVTALVPPAVSLWLQALIEGESRAQLASLKLLQV---GGAR-LSATLAARIPAE 323 +V L L+ Q LK + + + ++ E Sbjct: 356 LCVEEVVGMLGKKSDFDLLLRHAGN-FDADQYEHLKWVVLFEDASEPTVGDEYLQKLAKE 414 Query: 324 IGCQLQQVF-GMAEGLVNYTRLDDSAEKIIHTQGYPMCPDDEVWVADAEG----NPLPQG 378 +G + VF G E + + + M P E V G L Sbjct: 415 LGLEDVFVFRGPLESAYMVMW------RSLKRARWEMVPHVEAKVVGDRGTADARILAAN 468 Query: 379 EVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQG 429 G L +GP+ GYY + D GF + +D G +T+ G Sbjct: 469 TRGNLKLKGPHISAGYYNNAGLLTELVDERGFCSTSREAVMDERGQLTLHG 519 >2OGE-A nrPDB Length = 399 Score = 35.1 bits (79), Expect = 0.077, Method: Composition-based stats. Identities = 17/67 (25%), Positives = 23/67 (34%), Gaps = 7/67 (10%) Query: 57 AADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFS--HQRSELNA 114 A LA LR GI PG+ +V ++ A+ G PV H + Sbjct: 89 DALQLA--LRGLGIGPGDEVIV---PSHTYIASWLAVSATGATPVPVEPHEDHPTLDPLL 143 Query: 115 YASQIEP 121 I P Sbjct: 144 VEKAITP 150 >5VLB-A nrPDB Length = 446 Score = 35.1 bits (79), Expect = 0.078, Method: Composition-based stats. Identities = 34/163 (20%), Positives = 63/163 (38%), Gaps = 16/163 (9%) Query: 240 SPGSLGVFLAGGTVVLAADPSATLCFPLIEKHQVNVTALVPPAVSLWLQALIEGESRAQL 299 S S+G+++ GGT VL + I + V A P + ++ +A + Sbjct: 127 SINSVGLYVPGGTAVLPSTALMLAVPAQIAGCKTIVLANPPTRDGTTCKEVLYCAKKAGV 186 Query: 300 ASLKLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTRLDDSAEKIIHTQGYPM 359 L L+ GGA+ + +A E +++++FG V ++ + + + P Sbjct: 187 THL--LKAGGAQAISAMA--WGTETCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPA 242 Query: 360 CPDDEVWVADAEGNP-------LPQGEVG-----RLMTRGPYT 390 P + + +AD P L Q E G L+ G Sbjct: 243 GPSEVLVIADKHAIPSHVAADLLSQAEHGPDSQVVLVIAGDGV 285 >2C81-A nrPDB Length = 418 Score = 35.1 bits (79), Expect = 0.084, Method: Composition-based stats. Identities = 36/178 (20%), Positives = 56/178 (31%), Gaps = 28/178 (15%) Query: 1 MSIPFTRWPE--EFARRYREK-------------GYWQDLPLTDILTRHAASDSIAVIDG 45 M+IPF WPE + + R R K GYW + + R A + A +G Sbjct: 1 MTIPFDHWPEWPQHSDRTRRKIEEVFQSNRWAISGYWTGE---ESMERKFAK-AFADFNG 56 Query: 46 ERQLSYRELNQAADNLACSLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALF 105 A LA L GI G+ +V T A+L + PV Sbjct: 57 VPYCVPTTSGSTALMLA--LEALGIGEGDEVIV---PSLTWIATATAVLNVNALPVFVDV 111 Query: 106 SHQRSELNAYASQI----EPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSG 159 ++ + + +I + D +N EH+ + G Sbjct: 112 EADTYCIDPQLIKSAITDKTKAIIPVHLFGSMANMDEINEIAQEHNLFVIEDCAQSHG 169 >3M6I-A nrPDB Length = 363 Score = 34.7 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 23/127 (18%), Positives = 42/127 (33%), Gaps = 6/127 (4%) Query: 26 PLTDILTRHAASDSIAVIDGERQLSY---RELNQAADNLACSLRRQGIKPGETALVQLGN 82 P+ +L R+ + +SY L + LA L+R G++ G+ L+ Sbjct: 132 PVPGLLRRYV-NHPAVWCHKIGNMSYENGAMLEPLSVALA-GLQRAGVRLGDPVLICGA- 188 Query: 83 VAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPALLIADRQHALFSGDDFLNTF 142 IT G P++ + A E +R A S + +F Sbjct: 189 GPIGLITMLCAKAAGACPLVITDIDEGRLKFAKEICPEVVTHKVERLSAEESAKKIVESF 248 Query: 143 VTEHSSI 149 ++ Sbjct: 249 GGIEPAV 255 >5YHV-A nrPDB Length = 394 Score = 33.2 bits (74), Expect = 0.27, Method: Composition-based stats. Identities = 20/128 (15%), Positives = 34/128 (26%), Gaps = 6/128 (4%) Query: 61 LACSLRRQGIKPG-ETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQI 119 A RR GI + ++ G+ + F A G +A + A Sbjct: 84 AADYQRRHGITVEPDAVVITTGSSGGFLLAFLACFDAGDRVAMASPGYPCYRNILSALGC 143 Query: 120 EPALLIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPS 179 E + Q L + V N +G + + A+ Sbjct: 144 EVVEIPCGPQTRFQPTAQMLAEIDPPLRGVVVASPANPTGTVIPPEELAA-----IASWC 198 Query: 180 PADEVAYF 187 A +V Sbjct: 199 DASDVRLI 206 >3DR4-A nrPDB Length = 391 Score = 32.0 bits (71), Expect = 0.59, Method: Composition-based stats. Identities = 32/175 (18%), Positives = 58/175 (33%), Gaps = 18/175 (10%) Query: 64 SLRRQGIKPGETALVQLGNVAELYITFFALLKLGVAPVLALFSHQRSELNAYASQIEPAL 123 +L GI PG+ +V + ++ G PVL + L+A + Sbjct: 87 ALVAMGIGPGDEVIV---PSLTYIASANSVTYCGATPVLVDNDPRTFNLDA----AKLEA 139 Query: 124 LIADRQHALFSGDDFLNTFVTEHSSIRVVQLLNDSGEHNLQDAINHPAEDFTATPSPA-D 182 LI R A+ ++ + ++++ ++DA + S + Sbjct: 140 LITPRTKAIMP----VHLYGQICDMDPILEVARRHNLLVIEDAAEAVGATYRGKKSGSLG 195 Query: 183 EVAYFQLSGG---TTGTPKLIPRTHNDYYYSVR-RSVEICQFTQQTRYLCAIPAA 233 + A F G TTG + T ND + + R + RY I Sbjct: 196 DCATFSFFGNAIITTG--EGGMITTNDDDLAAKMRLLRGQGMDPNRRYWFPIVGF 248 >1NL3-A nrPDB Length = 922 Score = 31.6 bits (70), Expect = 0.96, Method: Composition-based stats. Identities = 17/100 (17%), Positives = 28/100 (28%), Gaps = 10/100 (10%) Query: 333 GMAEGLVN-YTRLDDSAEKIIHTQGYPMCPDDEVWVADAEGNPLPQGEVG--RLMTRGPY 389 G A+G N YT A + Y + +G + ++G L Sbjct: 256 GPADGASNWYTEFARLAPLMEKDVHYEVDLRKRTVGVHEKGVEFVEDQLGIDNLYEAANS 315 Query: 390 TFRGYYKSPQHNASAFDANGFYCSGDLISIDPEGYITVQG 429 Y + F S D I +G + + Sbjct: 316 PLVSYLNNALKAKELF-------SRDKDYIVRDGEVLIVD 348 >3J15-B nrPDB Length = 593 Score = 30.1 bits (66), Expect = 2.6, Method: Composition-based stats. Identities = 19/100 (19%), Positives = 33/100 (33%), Gaps = 20/100 (20%) Query: 449 NLLLRHPAVIYAALVSMEDELMGEKSCAYLVV---------KEPLRAVQVRRFLREQGIA 499 +L R P V +V + K+ A ++ ++ V R R + Sbjct: 92 FVLYRLPIVKDGMVVGIVGPNGTGKTTAVKILAGQLIPNLCEDNDSWDNVIRAFRGNELQ 151 Query: 500 EF------KLPDRVE---CVDSLPLTAVGKVDKKQLRQWL 530 + V VD LP GKV ++L + + Sbjct: 152 NYFERLKNGEIRPVVKPQYVDLLPKAVKGKV--RELLKKV 189 >5FXF-A nrPDB Length = 526 Score = 30.1 bits (66), Expect = 2.6, Method: Composition-based stats. Identities = 20/156 (12%), Positives = 44/156 (28%), Gaps = 35/156 (22%) Query: 196 TPKL-IPRT-HNDYYYSVRRSVEICQFTQQTRYLCAIPAAHNYAMSSPGSLGVFLAGGTV 253 P+ + RT S + F M + +LG+ G Sbjct: 185 LPQGEVMRTGMGALPGSDAWQLFPYGFGPFPD-----------GMFTQSNLGIVTKMGIA 233 Query: 254 VLAADPSATLCFPLIEKH-------------QVNVTAL--VPPAVSLWLQALIEGESRAQ 298 ++ P++ +K ++N+ L VP ++++ A + Sbjct: 234 LMQRPPASQSFLITFDKEEDLEQIVDIMLPLRINMAPLQNVPVLRNIFMDAAAVSKRTEW 293 Query: 299 LASLKLLQVGGARLSATLAARIPAEIGCQLQQVFGM 334 G + A R+ ++ +G Sbjct: 294 FD-------GDGPMPAEAIERMKKDLDLGFWNFYGT 322 >3KGX-A nrPDB Length = 393 Score = 30.1 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 9/32 (28%), Positives = 15/32 (46%) Query: 427 VQGREKDQINRGGEKIAAEEIENLLLRHPAVI 458 + R I + GE +E+E L +H V+ Sbjct: 120 IGARVHQMIKKPGEHYTLQEVEEGLAQHKPVL 151 >4YPL-A nrPDB Length = 555 Score = 28.2 bits (61), Expect = 9.3, Method: Composition-based stats. Identities = 23/101 (22%), Positives = 32/101 (31%), Gaps = 9/101 (8%) Query: 364 EVWVADAEGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLISIDPEG 423 EV G G++G +M Y + H FY DL P+G Sbjct: 375 EVAAVPGSGKLSLTGQLGEVMKESAQAALTYLR--AHTQDYGLPEDFYNKVDLHVHVPDG 432 Query: 424 YITVQGREKDQINRGGEKIAAEEIENLLLRHPAVIYAALVS 464 G G +A I + L R PA + A+ Sbjct: 433 ATPKDG------PSAGITMATA-IASALSRRPARMDIAMTG 466 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.128 0.323 Lambda K H 0.267 0.0393 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,344,050 Number of Sequences: 36641 Number of extensions: 721962 Number of successful extensions: 2478 Number of sequences better than 10.0: 61 Number of HSP's better than 10.0 without gapping: 93 Number of HSP's successfully gapped in prelim test: 22 Number of HSP's that attempted gapping in prelim test: 2021 Number of HSP's gapped (non-prelim): 143 length of query: 536 length of database: 10,336,785 effective HSP length: 102 effective length of query: 434 effective length of database: 6,599,403 effective search space: 2864140902 effective search space used: 2864140902 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 61 (28.2 bits)