BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P0A953 (406 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 2BZ4-A nrPDB 830 0.0 3OYT-A nrPDB 691 0.0 4XOX-A nrPDB 613 e-176 3U0E-A nrPDB 477 e-135 4QAV-A nrPDB 275 2e-74 4JPF-A nrPDB 265 4e-71 1J3N-A nrPDB 261 5e-70 4LS7-A nrPDB 254 5e-68 3O04-A nrPDB 254 5e-68 4JRH-A nrPDB 242 2e-64 2GQD-A nrPDB 239 2e-63 4DDO-A nrPDB 236 1e-62 3KZU-A nrPDB 229 2e-60 4JGA-A nrPDB 228 4e-60 4R8E-A nrPDB 226 2e-59 1OXH-A nrPDB 222 2e-58 2IX4-A nrPDB 222 2e-58 3HO9-A nrPDB 220 1e-57 3E60-A nrPDB 216 1e-56 1E5M-A nrPDB 214 5e-56 2IWZ-A nrPDB 208 3e-54 2GP6-A nrPDB 177 9e-45 1TQY-A nrPDB 175 4e-44 5W2O-A nrPDB 166 2e-41 6QSP-A nrPDB 107 7e-24 4OQJ-A nrPDB 92 3e-19 4CW4-A nrPDB 75 5e-14 1TQY-B nrPDB 75 6e-14 5ENY-A nrPDB 70 1e-12 3SS6-A nrPDB 35 0.076 2HF8-A nrPDB 30 1.6 4B3J-C nrPDB 28 4.9 4E1L-A nrPDB 28 7.0 3SZE-A nrPDB 28 8.9 >2BZ4-A nrPDB Length = 418 Score = 830 bits (2144), Expect = 0.0, Method: Compositional matrix adjust. Identities = 405/406 (99%), Positives = 405/406 (99%) Query: 1 MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLI 60 MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLI Sbjct: 13 MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLI 72 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM 120 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM Sbjct: 73 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM 132 Query: 121 RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG 180 RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG Sbjct: 133 RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG 192 Query: 181 KQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVV 240 KQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVV Sbjct: 193 KQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVV 252 Query: 241 EELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDTPIDYLNSHGT 300 EELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDTPIDYLNS GT Sbjct: 253 EELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDTPIDYLNSQGT 312 Query: 301 STPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSIN 360 STPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSIN Sbjct: 313 STPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSIN 372 Query: 361 IEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLKD 406 IEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLKD Sbjct: 373 IEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLKD 418 >3OYT-A nrPDB Length = 410 Score = 691 bits (1783), Expect = 0.0, Method: Compositional matrix adjust. Identities = 347/407 (85%), Positives = 377/407 (92%), Gaps = 3/407 (0%) Query: 1 MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDT--TG 58 MKRAVITGLGIVSSIGNNQQEVLASL+EGRSGITF+QE KD+GMRSHVWG+VKL + Sbjct: 4 MKRAVITGLGIVSSIGNNQQEVLASLQEGRSGITFAQEFKDAGMRSHVWGDVKLQSEPKD 63 Query: 59 LIDRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGAD 118 LIDRKV+RFMSDASIYA+L+M++AIAD+GLS ++ +N R GL+ GSGGGSPR QV G+D Sbjct: 64 LIDRKVLRFMSDASIYAYLAMQEAIADSGLS-DSQVSNFRSGLVVGSGGGSPRNQVAGSD 122 Query: 119 AMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQ 178 AMR PRGLK VGPY+VTKAMASGVSACLATPFKI GVNYSISSACATSAHCIG+A+E IQ Sbjct: 123 AMRTPRGLKGVGPYMVTKAMASGVSACLATPFKIKGVNYSISSACATSAHCIGHALELIQ 182 Query: 179 LGKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMV 238 LGKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTP KASRTYD RDGFVIAGGGGMV Sbjct: 183 LGKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPAKASRTYDQDRDGFVIAGGGGMV 242 Query: 239 VVEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDTPIDYLNSH 298 VVEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCM+MAM GVDTPIDY+N H Sbjct: 243 VVEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMQMAMAGVDTPIDYMNVH 302 Query: 299 GTSTPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPS 358 GTSTPVGDVKEL AIREVFG+ +PAIS+TKAMTGHSLGAAGV EAI+SLLM+EHGFIAPS Sbjct: 303 GTSTPVGDVKELGAIREVFGNNTPAISSTKAMTGHSLGAAGVHEAIFSLLMVEHGFIAPS 362 Query: 359 INIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLK 405 INI+ LDEQA G+NI+TETT RELTTVMSNSFGFGGTNATLVMRK + Sbjct: 363 INIDNLDEQAQGMNIITETTQRELTTVMSNSFGFGGTNATLVMRKYQ 409 >4XOX-A nrPDB Length = 404 Score = 613 bits (1582), Expect = e-176, Method: Compositional matrix adjust. Identities = 304/405 (75%), Positives = 344/405 (84%), Gaps = 3/405 (0%) Query: 1 MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLI 60 MKR VITG+GI+SSIGNN +EVLASL+ G+SGIT S++ K+ G+RS VWG++K++ I Sbjct: 1 MKRVVITGMGIISSIGNNVEEVLASLKAGKSGITASEQFKEHGLRSQVWGDLKINPEEHI 60 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM 120 DRK +RFM DA+ YA+LS+EQAIADAGL+PE N+ R G++AGSGG S QV D Sbjct: 61 DRKQMRFMGDAAAYAYLSLEQAIADAGLTPEQVSND-RTGIVAGSGGASSENQVIAVDTQ 119 Query: 121 RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG 180 R +G+K VGPY+V + M+S VSACLATPFKI GVNYSISSACATSAHCIGNAVE IQLG Sbjct: 120 R-EKGVKRVGPYMVPRTMSSTVSACLATPFKIRGVNYSISSACATSAHCIGNAVELIQLG 178 Query: 181 KQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVV 240 KQDIVFAGGGEEL W FDAMGALSTKYN+TPEKASRTYDA RDGFVI+GGGGMVVV Sbjct: 179 KQDIVFAGGGEELYWSQTMMFDAMGALSTKYNETPEKASRTYDADRDGFVISGGGGMVVV 238 Query: 241 EELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDTPIDYLNSHGT 300 EELEHALARGA IY EIVGYGATSDG DMVAPSGEGA+RCMKMAM GVD IDY+N+HGT Sbjct: 239 EELEHALARGAKIYGEIVGYGATSDGYDMVAPSGEGAIRCMKMAMQGVD-KIDYINTHGT 297 Query: 301 STPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSIN 360 STPVGDVKEL AI+EVFG SPAISATKAMTGH+LGAAGV EAIYS LML HGFIAPSIN Sbjct: 298 STPVGDVKELGAIQEVFGGNSPAISATKAMTGHALGAAGVHEAIYSTLMLHHGFIAPSIN 357 Query: 361 IEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLK 405 I+ LDE A GL+IVTE ++ELTTVMSNSFGFGGTNATLV++K + Sbjct: 358 IDTLDEAAQGLDIVTELREQELTTVMSNSFGFGGTNATLVIKKYQ 402 >3U0E-A nrPDB Length = 428 Score = 477 bits (1228), Expect = e-135, Method: Compositional matrix adjust. Identities = 246/408 (60%), Positives = 303/408 (74%), Gaps = 5/408 (1%) Query: 1 MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLI 60 M+R V+TG+GIVSSIG+N +EV ASLRE +SGI+ ++E + G R V G +D L+ Sbjct: 22 MRRVVVTGMGIVSSIGSNTEEVTASLREAKSGISRAEEYAELGFRCQVHGAPDIDIESLV 81 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM 120 DR+ +RF + + ++M+QAIADAGL+ E N R G+I GSGG S R V AD Sbjct: 82 DRRAMRFHGRGTAWNHIAMDQAIADAGLTEEEVSNE-RTGIIMGSGGPSTRTIVDSADIT 140 Query: 121 RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG 180 R +G K VGP+ V KAM+S SA LAT FKI G+NYSISSACATS HCIGNA E IQ G Sbjct: 141 R-EKGPKRVGPFAVPKAMSSTASATLATFFKIKGINYSISSACATSNHCIGNAYEMIQYG 199 Query: 181 KQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVV 240 KQD +FAGG E+L W ++ FDAMGA+S+KYNDTP ASR YD +RDGFVIAGG G++V+ Sbjct: 200 KQDRMFAGGCEDLDWTLSVLFDAMGAMSSKYNDTPSTASRAYDKNRDGFVIAGGAGVLVL 259 Query: 241 EELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDTPIDYLNSHGT 300 E+LE ALARGA IY EIVGYGATSDG DMVAPSGEGA+RCMKMA+ V + IDY+N H T Sbjct: 260 EDLETALARGAKIYGEIVGYGATSDGYDMVAPSGEGAIRCMKMALSTVTSKIDYINPHAT 319 Query: 301 STPVGDVKELAAIREVF--GDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPS 358 STP GD E+ AIR++F GD P I+ATK++TGHSLGA GVQEAIYSLLM+++ FI S Sbjct: 320 STPAGDAPEIEAIRQIFGAGDVCPPIAATKSLTGHSLGATGVQEAIYSLLMMQNNFICES 379 Query: 359 INIEELDEQAAGLNIVTETTDR-ELTTVMSNSFGFGGTNATLVMRKLK 405 +IEELD A + IV + D +L TV+SNSFGFGGTNATLV ++ + Sbjct: 380 AHIEELDPAFADMPIVRKRIDNVQLNTVLSNSFGFGGTNATLVFQRYQ 427 >4QAV-A nrPDB Length = 415 Score = 275 bits (704), Expect = 2e-74, Method: Compositional matrix adjust. Identities = 175/415 (42%), Positives = 238/415 (57%), Gaps = 15/415 (3%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK-LDTTGLI 60 +R VITGLG VS +GN E +L G+SGI S + S V G V+ D I Sbjct: 4 RRVVITGLGQVSPVGNTVAEAWDTLLAGKSGIGAITRFDASDINSRVAGEVRGFDIGQYI 63 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSG-GGSPRFQVFGADA 119 K R M Y + QAIAD+GL + R+G+ GSG GG P +V G Sbjct: 64 SAKEARRMDVFIHYGIAAALQAIADSGLDDVENLDKDRIGVNIGSGIGGLPSIEVTGKAV 123 Query: 120 MRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQL 179 + G G + + P+ + ++ + +S + G +Y + SAC T AH IGN+ I+ Sbjct: 124 IEG--GARKINPFFIPGSLINLISGHVTILKGYRGPSYGMVSACTTGAHAIGNSARLIKY 181 Query: 180 GKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMV 238 G DI+ AGG E + F AM ALST+ ND P ASR +D RDGFVI G G++ Sbjct: 182 GDADIMVAGGAEGAISTLGVGGFAAMKALSTR-NDDPATASRPWDKGRDGFVIGEGAGIL 240 Query: 239 VVEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMH--GVDTP-IDYL 295 V+EELEHA RGA IYAEIVG+G +SD + AP+ EG + A+ G++ +DY+ Sbjct: 241 VLEELEHAKKRGAKIYAEIVGFGMSSDAYHITAPNEEGPALAVTRALKDAGINPEDVDYV 300 Query: 296 NSHGTSTPVGDVKELAAIREVFGDKS--PAISATKAMTGHSLGAAGVQEAIYSLLMLEHG 353 N+HGTSTP+GD E A++ FG+ + +S+TK+MTGH LGAAG EA+YS+L + G Sbjct: 301 NAHGTSTPLGDANETKALKRAFGEHAYKTVVSSTKSMTGHLLGAAGGVEAVYSILAIHDG 360 Query: 354 FIAPSINIEELDEQAAGLNI---VTETTDRELTTVMSNSFGFGGTNATLVMRKLK 405 I P+INI E D + AG ++ E D E+ +SNSFGFGGTN TLV ++ K Sbjct: 361 KIPPTINIFEQDVE-AGCDLDYCANEARDAEIDVAISNSFGFGGTNGTLVFKRFK 414 >4JPF-A nrPDB Length = 436 Score = 265 bits (676), Expect = 4e-71, Method: Compositional matrix adjust. Identities = 171/417 (41%), Positives = 241/417 (57%), Gaps = 18/417 (4%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK-LDTTGLI 60 +R VITG+G++S +G + + GRSGI + + S + G+VK + + Sbjct: 26 RRVVITGMGMLSPLGLDVPSSWEGILAGRSGIAPIEHMDLSAYSTRFGGSVKGFNVEEYL 85 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSG-GGSPRFQVFGADA 119 K R + Y + QA+ D+GL N R+G+ GSG GG + Sbjct: 86 SAKEARKLDLFIQYGLAASFQAVRDSGLE-VTDANRERIGVSMGSGIGGLTNIENNCRSL 144 Query: 120 M-RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQ 178 +GPR + P+ V ++ + VS L+ + G NY++++AC T H IG A I Sbjct: 145 FEQGPR---RISPFFVPGSIINMVSGFLSIHLGLQGPNYALTTACTTGTHSIGMAARNIA 201 Query: 179 LGKQDIVFAGGGE-ELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGM 237 G+ D++ AGG E C F A ALST+ ND P +ASR +D RDGFV++ G G Sbjct: 202 YGEADVMVAGGSEMAACGLGLGGFGAARALSTR-NDEPTRASRPWDRDRDGFVLSDGSGA 260 Query: 238 VVVEELEHALARGAHIYAEIVGYGATSDGADMVAP--SGEGAVRCMKMAMH--GVDT-PI 292 +V+EELEHA ARGA IYAE+VG+G + D M AP G GA RCMK A+ G+D + Sbjct: 261 LVLEELEHARARGARIYAELVGFGMSGDAFHMTAPPEDGAGAARCMKNALRDAGLDPRQV 320 Query: 293 DYLNSHGTSTPVGDVKELAAIREVFGDKSPAI--SATKAMTGHSLGAAGVQEAIYSLLML 350 DY+N+HGTSTP GD+ E+AA++ VFG+ + A+ S+TK+MTGH LGAAG EAI+S+L L Sbjct: 321 DYINAHGTSTPAGDIAEIAAVKSVFGEHAHALSMSSTKSMTGHLLGAAGAVEAIFSVLAL 380 Query: 351 EHGFIAPSINIEELDEQAAGLNIVT-ETTDRELTTVMSNSFGFGGTNATLVMRKLKD 406 P+IN++ DE L++V E R++ +SNSFGFGGTN TLV R+ D Sbjct: 381 RDQVAPPTINLDNPDE-GCDLDLVAHEAKPRKIDVALSNSFGFGGTNGTLVFRRFAD 436 >1J3N-A nrPDB Length = 408 Score = 261 bits (666), Expect = 5e-70, Method: Compositional matrix adjust. Identities = 160/413 (38%), Positives = 234/413 (56%), Gaps = 14/413 (3%) Query: 1 MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLI 60 M+R V+TGLG ++ IG Q+ + G+SG+ S + + V +D + Sbjct: 1 MRRVVVTGLGALTPIGVGQEAFHKAQLAGKSGVRPITRFDASALPVRIAAEVDVDPGAYL 60 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSG-GGSPRFQVFGADA 119 DRK +R + YA ++ + A+ DAGL PE RVG + G+G GG ++ Sbjct: 61 DRKELRRLDRFVQYALIAAQLALEDAGLKPEDLDPE-RVGTLVGTGIGGMETWEAQSRVF 119 Query: 120 MRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQL 179 + RG + P+ + +A+ SA +A + G + ++ +ACAT A +G+A+ IQL Sbjct: 120 LE--RGPNRISPFFIPMMIANMASAHIAMRYGFTGPSSTVVTACATGADALGSALRMIQL 177 Query: 180 GKQDIVFAGGGEELCWEMAC-EFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMV 238 G+ D+V AGG E MA F M ALST+ N+ PEKASR + RDGFV+ G G++ Sbjct: 178 GEADLVLAGGTEAAITPMAIGAFAVMRALSTR-NEEPEKASRPFTLSRDGFVMGEGAGVL 236 Query: 239 VVEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDT-----PID 293 V+E EHA RGA IYAE+VG+G ++D + P EG + MA D + Sbjct: 237 VLEAYEHAKKRGARIYAELVGFGRSADAHHITEPHPEGKGAALAMARALKDAGIAPEQVG 296 Query: 294 YLNSHGTSTPVGDVKELAAIREVFGD--KSPAISATKAMTGHSLGAAGVQEAIYSLLMLE 351 Y+N+HGTSTPVGD E+ AI+ VFGD K +S+TK+M GH LGAAG EAI ++ L Sbjct: 297 YINAHGTSTPVGDRAEVLAIKRVFGDHAKRLMVSSTKSMIGHLLGAAGAVEAIATVQALY 356 Query: 352 HGFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKL 404 HG I P+IN+E+ D + L+ V E + ++ +SNSF FGG NA L +++ Sbjct: 357 HGVIPPTINLEDPDPE-LDLDFVPEPREAKVDYALSNSFAFGGHNAVLAFKRV 408 >4LS7-A nrPDB Length = 426 Score = 254 bits (649), Expect = 5e-68, Method: Compositional matrix adjust. Identities = 167/418 (39%), Positives = 235/418 (56%), Gaps = 23/418 (5%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK-LDTTGLI 60 KR V+TGLG +S +GN+ + G SGI + + V +K + + Sbjct: 17 KRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAEEYPAKVAAELKDFNVEDYM 76 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGG-----SPRFQVF 115 D+K R M + YA ++ + A+ DA L+ + PRVG+ GSG G +F++F Sbjct: 77 DKKEARKMDRFTQYAVVAAKMAVEDADLNITD-EIAPRVGVWVGSGIGGLETLESQFEIF 135 Query: 116 GADAMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVE 175 +GPR V P+ V + + ++ GVN +ACAT + IG+A + Sbjct: 136 ---LTKGPR---RVSPFFVPMMIPDMATGQISIALGAKGVNSCTVTACATGTNSIGDAFK 189 Query: 176 QIQLGKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGG 234 IQ G D++ GG E M+ F A ALST N P+ ASR +D +RDGFV+ G Sbjct: 190 VIQRGDADVMVTGGTEAPLTRMSFAGFSANKALST--NPDPKTASRPFDKNRDGFVMGEG 247 Query: 235 GGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAPS--GEGAVRCMKMAMHG---VD 289 G++V+EELEHALARGA IY EIVGYG+T D + AP+ GEG R M+ A+ Sbjct: 248 AGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDGEGGARAMQEAIKDAGIAP 307 Query: 290 TPIDYLNSHGTSTPVGDVKELAAIREVFGDKSP--AISATKAMTGHSLGAAGVQEAIYSL 347 IDY+N+HGTST D E AI+ VFG+ + A+S+TK+MTGH LGAAG EAI+S+ Sbjct: 308 EEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSSTKSMTGHLLGAAGGIEAIFSI 367 Query: 348 LMLEHGFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLK 405 L ++ G I P+INI+ DE+ + E +EL V+SNS GFGG NATL+ +K + Sbjct: 368 LAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYVLSNSLGFGGHNATLIFKKYQ 425 >3O04-A nrPDB Length = 413 Score = 254 bits (649), Expect = 5e-68, Method: Compositional matrix adjust. Identities = 168/415 (40%), Positives = 239/415 (57%), Gaps = 15/415 (3%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK-LDTTGLI 60 +R V+TG+G V+ IGN+ + + ++G +G+ L + +K D + Sbjct: 4 RRVVVTGIGAVTPIGNDAETSWENAKKGVNGVAKMTRLNPDDFPVKIAAELKDFDVEKYL 63 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSG-GGSPRFQVFGADA 119 ++K R M + YA S E A+ D+GL + N RVG+ GSG GG F+ Sbjct: 64 EKKEARKMDRFTHYAIASAEMAVQDSGLVIDDSNAN-RVGVWIGSGIGGMETFETQYEIF 122 Query: 120 MRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQL 179 + RG + V P+ V + S ++ F G+N + +ACAT+ + IG+A + I+ Sbjct: 123 LN--RGHRRVSPFFVPMMIPDMGSGQVSIRFGAKGINSTTVTACATATNSIGDAFKVIER 180 Query: 180 GKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMV 238 G D + GG E +M+ F A ALS N PE A R +D RDGF+I G G+V Sbjct: 181 GDADAMITGGAEAPITKMSLAGFTANKALS--LNPDPETACRPFDKDRDGFIIGEGAGIV 238 Query: 239 VVEELEHALARGAHIYAEIVGYGATSDGADMVAP--SGEGAVRCMKMAMHGVD-TP--ID 293 ++EE EHA ARGA IYAEIVGYGAT D + AP +GEGA R MKMA+ TP +D Sbjct: 239 ILEEYEHAKARGAKIYAEIVGYGATGDAYHITAPAPNGEGAARAMKMAIDDAGLTPDKVD 298 Query: 294 YLNSHGTSTPVGDVKELAAIREVFGD--KSPAISATKAMTGHSLGAAGVQEAIYSLLMLE 351 Y+N+HGTSTP D E AI+ VFG+ K AIS+TK+MTGH+LGA+G EAI++LL + Sbjct: 299 YINAHGTSTPYNDEYETQAIKTVFGEHAKKLAISSTKSMTGHTLGASGGIEAIFALLTIR 358 Query: 352 HGFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLKD 406 IAP+I+++ DE + E + + V+SNSFGFGG NATLV ++++D Sbjct: 359 DNIIAPTIHLKNQDEVCDLDYVPNEAREANVNVVISNSFGFGGHNATLVFKRIED 413 >4JRH-A nrPDB Length = 417 Score = 242 bits (618), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 158/417 (37%), Positives = 231/417 (55%), Gaps = 20/417 (4%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK-LDTTGLI 60 +R V+TG+G++S +GN + +L G+SGI + + + G VK D + Sbjct: 7 RRVVVTGMGMLSPVGNTVESSWKALLAGQSGIVNIEHFDTTNFSTRFAGLVKGFDCEQYM 66 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM 120 +K R M Y + QA+ D+GL +N R+G+ GSG G G A+ Sbjct: 67 SKKDARKMDLFIQYGIAAGIQALEDSGLEVNE-ENAARIGVAIGSGIGGLELIETGHQAL 125 Query: 121 --RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQ 178 +GPR V P+ V + + ++ L+ + G N +IS+AC T H IG+A I Sbjct: 126 IEKGPR---KVSPFFVPSTIVNMIAGNLSIMRGLRGPNIAISTACTTGLHNIGHAARMIA 182 Query: 179 LGKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGM 237 G D + AGG E+ + F A ALST+ ND P+KASR +D RDGFV+ G G+ Sbjct: 183 YGDADAMVAGGAEKASTPLGMAGFGAAKALSTR-NDEPQKASRPWDKDRDGFVLGDGAGI 241 Query: 238 VVVEELEHALARGAHIYAEIVGYGATSDGADMVAPS--GEGAVRCMKMAMH--GVD-TPI 292 +V+EE EHA ARGA IYAE+VG+G + D M +PS G G M+ AM GV I Sbjct: 242 MVLEEYEHAKARGAKIYAEVVGFGMSGDAYHMTSPSEDGSGGALAMEAAMRDAGVTGEQI 301 Query: 293 DYLNSHGTSTPVGDVKELAAIREVFGD---KSPAISATKAMTGHSLGAAGVQEAIYSLLM 349 Y+N+HGTSTP GDV E+ I+ G+ K +S+TK+MTGH LGAAG EAI +++ Sbjct: 302 GYVNAHGTSTPAGDVAEVKGIKRALGEAGTKQVLVSSTKSMTGHLLGAAGSVEAIITVMS 361 Query: 350 LEHGFIAPSINIEELDEQAAGLNIVTETTDR--ELTTVMSNSFGFGGTNATLVMRKL 404 L + P+IN++ E+ G+++V + + M NSFGFGGTN +L+ +++ Sbjct: 362 LVDQMVPPTINLDN-PEEGLGVDLVPHVARKVESMEYAMCNSFGFGGTNGSLIFKRM 417 >2GQD-A nrPDB Length = 437 Score = 239 bits (609), Expect = 2e-63, Method: Compositional matrix adjust. Identities = 165/416 (39%), Positives = 231/416 (55%), Gaps = 19/416 (4%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK-LDTTGLI 60 KR VITG+G +S IGN+ + + +G +GI + H+ G +K + I Sbjct: 28 KRVVITGMGALSPIGNDVKTTWENALKGVNGIDKITRIDTEPYSVHLAGELKNFNIEDHI 87 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSG-GGSPRFQVFGADA 119 D+K R M + YA ++ +A+ DA L + R+G+ GSG GG F++ Sbjct: 88 DKKEARRMDRFTQYAIVAAREAVKDAQLDINENTAD-RIGVWIGSGIGGMETFEIAHKQL 146 Query: 120 M-RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQ 178 M +GPR V P+ V + + ++ G N + +ACAT + IG A + +Q Sbjct: 147 MDKGPR---RVSPFFVPMLIPDMATGQVSIDLGAKGPNGATVTACATGTNSIGEAFKIVQ 203 Query: 179 LGKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGM 237 G D + GG E MA F A ALST ND E A R + RDGFV+ G G+ Sbjct: 204 RGDADAMITGGTEAPITHMAIAGFSASRALST--NDDIETACRPFQEGRDGFVMGEGAGI 261 Query: 238 VVVEELEHALARGAHIYAEIVGYGATSDGADMVAPS--GEGAVRCMKMAMH--GVDTP-I 292 +V+E LE A ARGA+IYAEIVGYG T D + AP+ GEG R M+ AM G++ + Sbjct: 262 LVIESLESAQARGANIYAEIVGYGTTGDAYHITAPAPEGEGGSRAMQAAMDDAGIEPKDV 321 Query: 293 DYLNSHGTSTPVGDVKELAAIREVFGD--KSPAISATKAMTGHSLGAAGVQEAIYSLLML 350 YLN+HGTSTPVGD+ E+ AI+ FG+ K +S+TK+MTGH LGA G EAI+S L + Sbjct: 322 QYLNAHGTSTPVGDLNEVKAIKNTFGEAAKHLKVSSTKSMTGHLLGATGGIEAIFSALSI 381 Query: 351 EHGFIAPSINIEELDEQAAGLNIV-TETTDRELTTVMSNSFGFGGTNATLVMRKLK 405 + +AP+I+ D + L+IV E D ++T MSNS GFGG NA LV +K + Sbjct: 382 KDSKVAPTIHAVTPDPE-CDLDIVPNEAQDLDITYAMSNSLGFGGHNAVLVFKKFE 436 >4DDO-A nrPDB Length = 451 Score = 236 bits (603), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 158/421 (37%), Positives = 236/421 (56%), Gaps = 24/421 (5%) Query: 3 RAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK--------- 53 R V+TG+GIVS +G ++ V L G SG+ + + + V G V+ Sbjct: 25 RVVVTGIGIVSPLGCGKELVWQRLIGGGSGLRRLGDDIAGELSAKVGGTVQDVAEDPEGG 84 Query: 54 LDTTGLIDRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSG-GGSPRF 112 D + K +R M A ++ ++A+A+AG +PEA Q R + SG GG P Sbjct: 85 FDPERSVPHKELRKMDRFIQMAMVAADEALAEAGWAPEAEQQRERTATVVASGIGGFPGL 144 Query: 113 QVFGADAMR--GPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCI 170 A+A+R RG++ + P+ + +++ + ++ + G +ACA S I Sbjct: 145 ----AEAVRIGETRGVRRLSPFTIPFFLSNLAAGQISIKHRFRGPLGCPVTACAASVQAI 200 Query: 171 GNAVEQIQLGKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGF 229 G+A+ I+ G+ D+V AGG E +++ F A ALST +++ P +ASR +D RDGF Sbjct: 201 GDAMRMIRTGEADVVLAGGAEAAFDKVSLGGFAAARALSTGFSEEPVRASRPFDRDRDGF 260 Query: 230 VIAGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVA--PSGEGAVRCMKMAMHG 287 V+ G MVVVE L+HALARGA AEI+GYG T+D M A G GA+R MK+A+ Sbjct: 261 VMGEGAAMVVVESLDHALARGARPIAEIIGYGTTADAYHMTAGPDDGSGAMRAMKLALRM 320 Query: 288 VDTP---IDYLNSHGTSTPVGDVKELAAIREVFG-DKSPAISATKAMTGHSLGAAGVQEA 343 D +DY+N+H TSTPVGD E+ A++ VFG PAIS+TK+ TGH LGAAG EA Sbjct: 321 GDVAPEQVDYVNAHATSTPVGDAGEIEALKTVFGVGAGPAISSTKSATGHLLGAAGAIEA 380 Query: 344 IYSLLMLEHGFIAPSINIEELDEQAAGLNIVTETTDR-ELTTVMSNSFGFGGTNATLVMR 402 +S+L L G + ++N+E D A GL+++ + +SN FGFGG NA+++ R Sbjct: 381 AFSILALRDGVLPGTLNLEHPDPAADGLDLIGPAARHVPVEIALSNGFGFGGVNASVLFR 440 Query: 403 K 403 + Sbjct: 441 R 441 >3KZU-A nrPDB Length = 428 Score = 229 bits (583), Expect = 2e-60, Method: Compositional matrix adjust. Identities = 161/419 (38%), Positives = 233/419 (55%), Gaps = 18/419 (4%) Query: 1 MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLD--TTG 58 M+R VITGLG+VS + + +E L G SG E + + + + + T G Sbjct: 9 MRRVVITGLGLVSPLASGVEETWKRLLAGESGARRVTEFEVDDLACQIACRIPVGDGTNG 68 Query: 59 L------IDRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRF 112 +D K R + +YA + +QA+ DAG PE ++ R G++ GSG G Sbjct: 69 TFNPDLHMDPKEQRKVDPFIVYAVGAADQALDDAGWHPENDEDQVRTGVLIGSGIGGIEG 128 Query: 113 QVFGADAMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGN 172 V +R +G + + P+ + + + S ++ K+ G N+S+ +ACAT H IG+ Sbjct: 129 IVEAGYTLRD-KGPRRISPFFIPGRLINLASGHVSIKHKLRGPNHSVVTACATGTHAIGD 187 Query: 173 AVEQIQLGKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVI 231 A I G D++ AGG E ++ F A ALST+ ND P ASR YD RDGFV+ Sbjct: 188 AARLIAFGDADVMVAGGTESPVSRISLAGFAACKALSTERNDDPTAASRPYDEDRDGFVM 247 Query: 232 AGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAP--SGEGAVRCMKMAMHG-- 287 G G+VV+EELEHALARGA IYAE++GYG + D + AP SGEGA RCM A+ Sbjct: 248 GEGAGIVVLEELEHALARGAKIYAEVIGYGMSGDAFHITAPTESGEGAQRCMVAALKRAG 307 Query: 288 -VDTPIDYLNSHGTSTPVGDVKELAAIREVFGDKSPAI--SATKAMTGHSLGAAGVQEAI 344 V IDY+N+HGTST + D EL A+ V G+ + I S+TK+ GH LGAAG EA+ Sbjct: 308 IVPDEIDYINAHGTST-MADTIELGAVERVVGEAAAKISMSSTKSSIGHLLGAAGAAEAV 366 Query: 345 YSLLMLEHGFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRK 403 +S L + ++N++ Q + + +R++ +SNSFGFGGTNA+LV+R+ Sbjct: 367 FSTLAIRDNIAPATLNLDNPAAQTRIDLVPHKPRERKIDVALSNSFGFGGTNASLVLRR 425 >4JGA-A nrPDB Length = 437 Score = 228 bits (581), Expect = 4e-60, Method: Compositional matrix adjust. Identities = 158/421 (37%), Positives = 235/421 (55%), Gaps = 20/421 (4%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNV--------K 53 KR VITGLG+V+ +G N ++ +G SGI E S + + G + K Sbjct: 16 KRVVITGLGLVTPVGLNVNSSWKNIVDGVSGIKTITEFDTSKLACKIAGLIDNSEKDGFK 75 Query: 54 LDT-TGLIDRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRF 112 L+ T D + M Y + +A+ D+G P+ ++ R GLI GSG G + Sbjct: 76 LENFTQADDINRLSKMDKFIHYGVAAATEAVEDSGWLPDDEKSRDRTGLILGSGIGGLKM 135 Query: 113 QVFGADAMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGN 172 + + K V P+ + ++ + +S ++ + G N + +AC+T AH IG+ Sbjct: 136 IEDTSIKLYQENNGK-VSPFFIPASLINLLSGLVSIKYGFSGPNQTAVTACSTGAHAIGD 194 Query: 173 AVEQIQLGKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVI 231 A+ I+ G D++ AGG E + F A AL TKYND P+KASR +D R GFV+ Sbjct: 195 AMRMIKHGYADVMIAGGAEAPVTPVGVAGFVAARALCTKYNDNPKKASRPWDKDRSGFVM 254 Query: 232 AGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVA--PSGEGAVRCMKMAM-HGV 288 G G+VV+EE EHAL RGA +Y E++GYG+T D M A P G GA R M+ AM Sbjct: 255 GEGAGVVVLEEYEHALNRGAKVYGEVIGYGSTGDAYHMTAPHPEGRGAYRAMRDAMLDAT 314 Query: 289 DTP--IDYLNSHGTSTPVGDVKELAAIREVFGDKSPAI--SATKAMTGHSLGAAGVQEAI 344 TP IDY+N+HGTST +GD ELAA++++F + +P + S+TK+ GH LGAAG E I Sbjct: 315 ITPDMIDYINAHGTSTTLGDGIELAAVQKLFLEANPKVLMSSTKSSIGHLLGAAGSVEFI 374 Query: 345 YSLLMLEHGFIAPSINIE-ELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRK 403 +S L + P++N++ +DE L + + ++ V+SNSFGFGGTNA+LV++ Sbjct: 375 FSALAIRDQIAPPTLNLDTPMDEVNIDL-VALKAKKTKIDYVLSNSFGFGGTNASLVIKS 433 Query: 404 L 404 + Sbjct: 434 I 434 >4R8E-A nrPDB Length = 413 Score = 226 bits (575), Expect = 2e-59, Method: Compositional matrix adjust. Identities = 156/415 (37%), Positives = 226/415 (54%), Gaps = 17/415 (4%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK-LDTTGLI 60 +R V+TGLG++S +GN + ++ G+SGI+ S + G VK + I Sbjct: 4 RRVVVTGLGMLSPVGNTVESTWKAVLAGQSGISLIDHFDTSAYATRFAGLVKDFNCEDYI 63 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLS-PEAYQNNPRVGLIAGSGGGSPRFQVFGADA 119 RK R M Y + QA+ DAGL EA + + +G GG + A Sbjct: 64 SRKDARKMDAFIQYGVAAGMQAMQDAGLDITEANASRIGAAIGSGIGGLGLIEENHTALV 123 Query: 120 MRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQL 179 GPR + P+ V + + ++ L + + G + SI++AC + H IG+A I Sbjct: 124 NGGPR---KISPFFVPSTIVNMIAGHLTIMYGLRGPSISIATACTSGVHNIGHAARIIAY 180 Query: 180 GKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMV 238 D++ AGG E+ + F A ALST+ ND P+ ASR +D RDGFV+ G GM+ Sbjct: 181 NDADVMVAGGAEKASTPLGVGGFGAARALSTR-NDNPQAASRPWDKDRDGFVLGDGAGMM 239 Query: 239 VVEELEHALARGAHIYAEIVGYGATSDGADMVAP--SGEGAVRCMKMAMH--GVDTP-ID 293 V+EE EHA RGA IYAE+VG+G +SD M +P G GA M A+ G+ T I Sbjct: 240 VLEEYEHAKKRGAKIYAEVVGFGMSSDAYHMTSPPEDGSGAALAMVNALRDAGITTSQIG 299 Query: 294 YLNSHGTSTPVGDVKELAAIREVFGDKSPA--ISATKAMTGHSLGAAGVQEAIYSLLMLE 351 Y+N+HGTSTP GD E A++ VFG+ + +S+TK+MTGH LGAAG E+I+++L L Sbjct: 300 YINAHGTSTPAGDKAETQAVKSVFGEDAYKVMVSSTKSMTGHLLGAAGAVESIFTVLALR 359 Query: 352 HGFIAPSINIEELDEQAAGLNIVTETTD--RELTTVMSNSFGFGGTNATLVMRKL 404 I +IN++ DE L+ V +++ + NSFGFGGTN +LV RK+ Sbjct: 360 DQAIPATINLDNPDE-GCDLDYVPHDARQVKDMEYTLCNSFGFGGTNGSLVFRKV 413 >1OXH-A nrPDB Length = 430 Score = 222 bits (566), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 147/415 (35%), Positives = 225/415 (54%), Gaps = 16/415 (3%) Query: 1 MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK---LDTT 57 + R V+TG G+ S IGN +E SL G+ GI + S H ++ D Sbjct: 22 LNRVVVTGYGVTSPIGNTPEEFWNSLATGKIGIGGITKFDHSDFDVHNAAEIQDFPFDKY 81 Query: 58 GLIDRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGA 117 + + RF + S+YA + ++A+ A L EA N R G+I SG G + ++ Sbjct: 82 -FVKKDTNRF-DNYSLYALYAAQEAVNHANLDVEAL-NRDRFGVIVASGIGGIK-EIEDQ 137 Query: 118 DAMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQI 177 +G K V P + KA+ + S +A F +GV SI++AC++S IG+A I Sbjct: 138 VLRLHEKGPKRVKPMTLPKALPNMASGNVAMRFGANGVCKSINTACSSSNDAIGDAFRSI 197 Query: 178 QLGKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGG 236 + G QD++ GG E A F A+ ALST + P +AS +D R+GFV+ G G Sbjct: 198 KFGFQDVMLVGGTEASITPFAIAGFQALTALST--TEDPTRASIPFDKDRNGFVMGEGSG 255 Query: 237 MVVVEELEHALARGAHIYAEIVGYGATSDGADMVA--PSGEGAVRCMKMAMHGVD-TP-- 291 M+V+E LEHA RGA I AE+VGYG T D M + P G+GA++ +K+A+ + +P Sbjct: 256 MLVLESLEHAEKRGATILAEVVGYGNTCDAYHMTSPHPEGQGAIKAIKLALEEAEISPEQ 315 Query: 292 IDYLNSHGTSTPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLE 351 + Y+N+HGTSTP + E AI V G + P +S+TK+ TGH LGAAG EAI ++ + Sbjct: 316 VAYVNAHGTSTPANEKGESGAIVAVLGKEVP-VSSTKSFTGHLLGAAGAVEAIVTIEAMR 374 Query: 352 HGFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLKD 406 H F+ + E+ + + + ++E+ +SN+FGFGG NA L ++ ++ Sbjct: 375 HNFVPMTAGTSEVSDYIEANVVYGQGLEKEIPYAISNTFGFGGHNAVLAFKRWEN 429 >2IX4-A nrPDB Length = 431 Score = 222 bits (566), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 156/431 (36%), Positives = 226/431 (52%), Gaps = 34/431 (7%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLID 61 +R V+TGLG+V+ +G + L +G GI L D M+S KL T + Sbjct: 1 RRVVVTGLGMVTPLGRGVETTWRRLIDGECGIR-GLTLDDLKMKSFD-EETKLYTFDQLS 58 Query: 62 RKVVRFMS--------DASI------------YAFLSMEQAIADAGLSPEAYQNNPRVGL 101 KV F+ D ++ YA + ++A+ DA P + R G+ Sbjct: 59 SKVAAFVPYGSNPGEFDEALWLNSKAVANFIGYAVCAADEALRDAEWLPTEEEEKERTGV 118 Query: 102 IAGSGGGSPRFQVFGADAMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISS 161 G G GS + A + + L+ + P+ + K + + S ++ + G N++ + Sbjct: 119 SIGGGIGS-ICDIVEAAQLICEKRLRRLSPFFIPKILVNMASGHVSMKYGFQGPNHAAVT 177 Query: 162 ACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASR 220 ACAT AH IG+A IQ G D++ AGG E ++ F ALSTK+N +P++ASR Sbjct: 178 ACATGAHSIGDATRMIQFGDADVMVAGGTESSIDALSVAGFSRSRALSTKFNSSPQEASR 237 Query: 221 TYDAHRDGFVIAGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAP--SGEGAV 278 +D RDGFVI G G++V+EE EHA RGA IYAE+ GYG + D + P G+GAV Sbjct: 238 PFDCDRDGFVIGEGSGVIVLEEYEHAKRRGAKIYAELCGYGMSGDAHHITQPPEDGKGAV 297 Query: 279 RCMKMAMHG---VDTPIDYLNSHGTSTPVGDVKELAAIREVFGDKSP----AISATKAMT 331 M A+ IDY+N+H TSTP+GD E AI+ VF + + A S+TK T Sbjct: 298 LAMTRALRQSGLCPNQIDYVNAHATSTPIGDAVEARAIKTVFSEHATSGTLAFSSTKGAT 357 Query: 332 GHSLGAAGVQEAIYSLLMLEHGFIAPSINIEELDEQAAGLNIVTETTDRELT-TVMSNSF 390 GH LGAAG EAI+S+L + HG ++N++ D + T+ + L T MSNSF Sbjct: 358 GHLLGAAGAVEAIFSILAIHHGVAPMTLNVKNPDPIFDKRFMPLTTSKKMLVRTAMSNSF 417 Query: 391 GFGGTNATLVM 401 GFGGTNA+L+ Sbjct: 418 GFGGTNASLLF 428 >3HO9-A nrPDB Length = 427 Score = 220 bits (560), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 151/414 (36%), Positives = 221/414 (53%), Gaps = 15/414 (3%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK-LDTTGLI 60 +R V+TGLG++S +GN + +L G+SGI+ S + G VK + +I Sbjct: 18 RRVVVTGLGMLSPVGNTVESTWKALLAGQSGISLIDHFDTSAYATKFAGLVKDFNCEDII 77 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM 120 RK R M Y ++ QA+ D+GL I GG + M Sbjct: 78 SRKEQRKMDAFIQYGIVAGVQAMQDSGLEITEENATRIGAAIGSGIGGLGLIEENHTSLM 137 Query: 121 RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG 180 G G + + P+ V + + V+ L + + G + SI++A + H IG+A I G Sbjct: 138 NG--GPRKISPFFVPSTIVNMVAGHLTIMYGLRGPSISIATAATSGVHNIGHAARIIAYG 195 Query: 181 KQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVV 239 D++ AGG E+ + F A ALST+ ND P+ ASR +D RDGFV+ G GM+V Sbjct: 196 DADVMVAGGAEKASTPLGVGGFGAARALSTR-NDNPQAASRPWDKERDGFVLGDGAGMLV 254 Query: 240 VEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDTPID-----Y 294 +EE EHA RGA IYAE+VG+G +SD M +P GA + MA D I+ Y Sbjct: 255 LEEYEHAKKRGAKIYAELVGFGMSSDAYHMTSPPENGAGAALAMANALRDAGIEASQIGY 314 Query: 295 LNSHGTSTPVGDVKELAAIREVFGDKSPA--ISATKAMTGHSLGAAGVQEAIYSLLMLEH 352 +N+HGTSTP GD E A++ +FG+ + +S+TK+MTGH LGAAG E+IYS+L L Sbjct: 315 VNAHGTSTPAGDKAEAQAVKTIFGEAASRVLVSSTKSMTGHLLGAAGAVESIYSILALRD 374 Query: 353 GFIAPSINIEELDEQAAGLNIVTETTDRE--LTTVMSNSFGFGGTNATLVMRKL 404 + P+IN++ DE L+ V + + + NSFGFGGTN +L+ +K+ Sbjct: 375 QAVPPTINLDNPDE-GCDLDFVPHEARQVSGMEYTLCNSFGFGGTNGSLIFKKI 427 >3E60-A nrPDB Length = 424 Score = 216 bits (551), Expect = 1e-56, Method: Compositional matrix adjust. Identities = 162/426 (38%), Positives = 238/426 (55%), Gaps = 26/426 (6%) Query: 1 MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWG---------- 50 M+R VITGLG+VS + + + L EG+SG+ E S + + Sbjct: 5 MRRVVITGLGLVSPLAGDVEYSWKRLLEGKSGVRRITEFDVSDLSCQIAARIPVGDGTNG 64 Query: 51 --NVKLDTTGLIDRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGG 108 N L RKV F+ +YA + +QA+ADA P++ ++ G++ GSG G Sbjct: 65 TYNADLHMESKEQRKVDAFI----VYAIAAADQALADAEWFPKSDEDQICTGVLIGSGIG 120 Query: 109 SPRFQVFGADAMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAH 168 V +R +G + + P+ + + + S ++ + + G N+S+ +AC+T AH Sbjct: 121 GIEGIVEAGYTLRD-KGPRRISPFFIPGRLINLASGYVSIKYGLRGPNHSVVTACSTGAH 179 Query: 169 CIGNAVEQIQLGKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRD 227 IG+A I LG D++ AGG E ++ F A ALST ND PE+ASR YD RD Sbjct: 180 AIGDAARLIALGDADVMLAGGTESPINRISLAGFSACRALSTCRNDDPERASRPYDVDRD 239 Query: 228 GFVIAGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAP--SGEGAVRCMKMAM 285 GFV+ G +VV+EELEHA RGA IYAEI+GYG + D + AP SGEGA R M A+ Sbjct: 240 GFVMGEGAAIVVLEELEHAKKRGARIYAEIIGYGLSGDAYHITAPSESGEGAQRSMMAAL 299 Query: 286 HGVD---TPIDYLNSHGTSTPVGDVKELAAIREVFGDKSP--AISATKAMTGHSLGAAGV 340 + +DY+N+HGTST + DV ELAA+ V G +P ++S+TK+ GH LGAAG Sbjct: 300 KRAQVNVSELDYINAHGTST-MADVIELAAVERVLGYYAPQVSMSSTKSSIGHLLGAAGA 358 Query: 341 QEAIYSLLMLEHGFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLV 400 EAI+ +L + ++N+E + + + +R++ TV+SNSFGFGGTNA+LV Sbjct: 359 AEAIFCVLAIRDNIAPATLNLENPSIETKIDLVPHKPRERKIDTVLSNSFGFGGTNASLV 418 Query: 401 MRKLKD 406 MR+ + Sbjct: 419 MRRFSE 424 >1E5M-A nrPDB Length = 416 Score = 214 bits (546), Expect = 5e-56, Method: Compositional matrix adjust. Identities = 145/413 (35%), Positives = 216/413 (52%), Gaps = 12/413 (2%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK-LDTTGLI 60 KR V+TGLG ++ IGN Q+ L EGR+GI S G VK D T + Sbjct: 7 KRVVVTGLGAITPIGNTLQDYWQGLMEGRNGIGPITRFDASDQACRFGGEVKDFDATQFL 66 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM 120 DRK + M +A + +QAI DA L N +G++ G+G G + + + Sbjct: 67 DRKEAKRMDRFCHFAVCASQQAINDAKLVINEL-NADEIGVLIGTGIGGLKV-LEDQQTI 124 Query: 121 RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG 180 +G P+++ +A+ S A G N +ACA ++ IG+A +Q G Sbjct: 125 LLDKGPSRCSPFMIPMMIANMASGLTAINLGAKGPNNCTVTACAAGSNAIGDAFRLVQNG 184 Query: 181 KQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVV 239 + GG E ++ F + ALS + ND P ASR +D RDGFV+ G G+++ Sbjct: 185 YAKAMICGGTEAAITPLSYAGFASARALSFR-NDDPLHASRPFDKDRDGFVMGEGSGILI 243 Query: 240 VEELEHALARGAHIYAEIVGYGATSDGADMVA--PSGEGAVRCMKMAMH--GVDTP-IDY 294 +EELE ALARGA IY E+VGY T D + A P G GA R + A+ G+ + Y Sbjct: 244 LEELESALARGAKIYGEMVGYAMTCDAYHITAPVPDGRGATRAIAWALKDSGLKPEMVSY 303 Query: 295 LNSHGTSTPVGDVKELAAIREVFGDK--SPAISATKAMTGHSLGAAGVQEAIYSLLMLEH 352 +N+HGTSTP DV E AI++ G+ + A+S+TK+MTGH LG +G EA+ +++ + Sbjct: 304 INAHGTSTPANDVTETRAIKQALGNHAYNIAVSSTKSMTGHLLGGSGGIEAVATVMAIAE 363 Query: 353 GFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLK 405 + P+IN+E D + + ++ + +SNSFGFGG N TL +K + Sbjct: 364 DKVPPTINLENPDPECDLDYVPGQSRALIVDVALSNSFGFGGHNVTLAFKKYQ 416 >2IWZ-A nrPDB Length = 438 Score = 208 bits (530), Expect = 3e-54, Method: Compositional matrix adjust. Identities = 145/425 (34%), Positives = 223/425 (52%), Gaps = 29/425 (6%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGIT--FSQELKDSGMRSHVWGNV------- 52 +R VITG+G+V+ +G V L G SGI +E K + V V Sbjct: 21 RRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGEEYKS--IPCSVAAYVPRGSDEG 78 Query: 53 KLDTTGLIDRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRF 112 + + + + ++ MS +I A + E A+ D+G P++ + G+ G G Sbjct: 79 QFNEQNFVSKSDIKSMSSPTIMAIGAAELAMKDSGWHPQSEADQVATGVAIGMG--MIPL 136 Query: 113 QVFGADAMR-GPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIG 171 +V A+ +G V P+ V K + + + ++ +K+ G N+++S+AC T AH +G Sbjct: 137 EVVSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKGPNHAVSTACTTGAHAVG 196 Query: 172 NAVEQIQLGKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFV 230 ++ I G D++ AGG + ++ F ALST N P+ A R + RDGFV Sbjct: 197 DSFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALST--NSDPKLACRPFHPKRDGFV 254 Query: 231 IAGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVA--PSGEGAVRCMKMAMH-- 286 + G ++V+EE EHA+ R A IYAE++GYG + D + A P GEGA+RCM A+ Sbjct: 255 MGEGAAVLVLEEYEHAVQRRARIYAEVLGYGLSGDAGHITAPDPEGEGALRCMAAALKDA 314 Query: 287 GVDT-PIDYLNSHGTSTPVGDVKELAAIREVFGDKSP--AISATKAMTGHSLGAAGVQEA 343 GV I Y+N+H TSTP+GD E AI+ +F D + A+S+TK TGH LGAAG EA Sbjct: 315 GVQPEEISYINAHATSTPLGDAAENKAIKHLFKDHAYALAVSSTKGATGHLLGAAGAVEA 374 Query: 344 IYSLLMLEHGFIAPSINIE----ELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATL 399 ++ L + + P++N++ E D L T++ ++NSFGFGGTNATL Sbjct: 375 AFTTLACYYQKLPPTLNLDCSEPEFDLNYVPLKAQEWKTEKRFIG-LTNSFGFGGTNATL 433 Query: 400 VMRKL 404 + L Sbjct: 434 CIAGL 438 >2GP6-A nrPDB Length = 434 Score = 177 bits (448), Expect = 9e-45, Method: Compositional matrix adjust. Identities = 132/404 (32%), Positives = 200/404 (49%), Gaps = 14/404 (3%) Query: 5 VITGLGIVSSIGNNQQEVLASLREGRSGITFSQE--LKDSGMRSHVWGNVKLDTTGLIDR 62 V+TG+ + +++ + + L + +SGI + +++ + + G++ + + R Sbjct: 31 VVTGIAMTTALATDAETTWKLLLDRQSGIRTLDDPFVEEFDLPVRIGGHLLEEFDHQLTR 90 Query: 63 KVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAMRG 122 +R M + + + +AG SPE N R+ + G+G GS VF D MR Sbjct: 91 IELRRMGYLQRMSTVLSRRLWENAG-SPEVDTN--RLMVSIGTGLGSAEELVFSYDDMRA 147 Query: 123 PRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQ 182 RG+KAV P V K M +G +A + + SACA+ A I A +QI LG+ Sbjct: 148 -RGMKAVSPLTVQKYMPNGAAAAVGLERHAKAGVMTPVSACASGAEAIARAWQQIVLGEA 206 Query: 183 DIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVVE 241 D GG E + F M + + ND P A R +D RDGFV GG ++++E Sbjct: 207 DAAICGGVETRIEAVPIAGFAQMRIVMSTNNDDPAGACRPFDRDRDGFVFGEGGALLLIE 266 Query: 242 ELEHALARGAHIYAEIVGYGATSDGADMVAP------SGEGAVRCMKMAMHGVDTPIDYL 295 EHA ARGA+I A I+G TSDG MVAP +G R +++A ID++ Sbjct: 267 TEEHAKARGANILARIMGASITSDGFHMVAPDPNGERAGHAITRAIQLAGLAPGD-IDHV 325 Query: 296 NSHGTSTPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFI 355 N+H T T VGD+ E AI G PA+ A K+ GHS+GA G E+I ++L L I Sbjct: 326 NAHATGTQVGDLAEGRAINNALGGNRPAVYAPKSALGHSVGAVGAVESILTVLALRDQVI 385 Query: 356 APSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATL 399 P++N+ LD + + E ++NSFGFGG N + Sbjct: 386 PPTLNLVNLDPEIDLDVVAGEPRPGNYRYAINNSFGFGGHNVAI 429 >1TQY-A nrPDB Length = 424 Score = 175 bits (443), Expect = 4e-44, Method: Compositional matrix adjust. Identities = 135/417 (32%), Positives = 203/417 (48%), Gaps = 20/417 (4%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTT--GL 59 +R VITG+G+ + GN ++ L GR+ S RS V D G Sbjct: 3 RRVVITGVGVRAPGGNGTRQFWELLTSGRTATRRISFFDPSPYRSQVAAEADFDPVAEGF 62 Query: 60 IDRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSP----RFQVF 115 R++ R M AS +A +A A +GL P+ + RVG+ GS + R + Sbjct: 63 GPRELDR-MDRASQFAVACAREAFAASGLDPDTL-DPARVGVSLGSAVAAATSLEREYLL 120 Query: 116 GADAMRGPRGLKA-VGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAV 174 +D+ R A + ++ + S + A +A G +S+ C + +GNAV Sbjct: 121 LSDSGRDWEVDAAWLSRHMFDYLVPSVMPAEVAWAVGAEGPVTMVSTGCTSGLDSVGNAV 180 Query: 175 EQIQLGKQDIVFAGGGEELCWEM--ACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIA 232 I+ G D++FAG + + AC FDA+ A +T ND PE ASR +D RDGFV+A Sbjct: 181 RAIEEGSADVMFAGAADTPITPIVVAC-FDAIRA-TTARNDDPEHASRPFDGTRDGFVLA 238 Query: 233 GGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEG-----AVRCMKMAMHG 287 G M V+E+ + ALARGA I+AEI GY + M +G +R Sbjct: 239 EGAAMFVLEDYDSALARGARIHAEISGYATRCNAYHMTGLKADGREMAETIRVALDESRT 298 Query: 288 VDTPIDYLNSHGTSTPVGDVKELAAIREVFGD--KSPAISATKAMTGHSLGAAGVQEAIY 345 T IDY+N+HG+ T D E AA + G+ + +S+ K+M GHSLGA G E Sbjct: 299 DATDIDYINAHGSGTRQNDRHETAAYKRALGEHARRTPVSSIKSMVGHSLGAIGSLEIAA 358 Query: 346 SLLMLEHGFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMR 402 +L LEHG + P+ N+ D + + E +R+L +V++ GFGG + +V+R Sbjct: 359 CVLALEHGVVPPTANLRTSDPECDLDYVPLEARERKLRSVLTVGSGFGGFQSAMVLR 415 >5W2O-A nrPDB Length = 439 Score = 166 bits (419), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 134/396 (33%), Positives = 194/396 (48%), Gaps = 18/396 (4%) Query: 14 SIGNNQQEVLASLREGRSGITFSQE--LKDSGMRSHVWGNVKLDTTGLIDRKVVRFMSDA 71 SI + + L G SGI ++ + + + G++K + R +R MS Sbjct: 47 SISPDIESTWKGLLAGESGIHALEDEFVTKWDLAVKIGGHLKDPVDSHMGRLDMRRMSYV 106 Query: 72 SIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAMR--GPRGLKAV 129 L Q AG SPE + R ++ G+G G V D M GPR V Sbjct: 107 QRMGKLLGGQLWESAG-SPEVDPD--RFAVVVGTGLGGAERIVESYDLMNAGGPR---KV 160 Query: 130 GPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGG 189 P V M +G +A + + SAC++ + I +A QI +G D+ GG Sbjct: 161 SPLAVQMIMPNGAAAVIGLQLGARAGVMTPVSACSSGSEAIAHAWRQIVMGDADVAVCGG 220 Query: 190 GEELCWEMA-CEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVVEELEHALA 248 E + F M A+ST+ ND PE+ASR +D RDGFV G ++++E EHA A Sbjct: 221 VEGPIEALPIAAFSMMRAMSTR-NDEPERASRPFDKDRDGFVFGEAGALMLIETEEHAKA 279 Query: 249 RGAHIYAEIVGYGATSDGADMVAPSGEG--AVRCM--KMAMHGVDTP-IDYLNSHGTSTP 303 RGA A ++G G TSD MVAP+ +G A R M + + G+ ID++N+HGT+TP Sbjct: 280 RGAKPLARLLGAGITSDAFHMVAPAADGVRAGRAMTRSLELAGLSPADIDHVNAHGTATP 339 Query: 304 VGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSINIEE 363 +GD E AIR V G A+ A K+ GHS+GA G E++ ++L L G I P++N E Sbjct: 340 IGDAAEANAIR-VAGCDQAAVYAPKSALGHSIGAVGALESVLTVLTLRDGVIPPTLNYET 398 Query: 364 LDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATL 399 D + + E + ++NSFGFGG N L Sbjct: 399 PDPEIDLDVVAGEPRYGDYRYAVNNSFGFGGHNVAL 434 >6QSP-A nrPDB Length = 406 Score = 107 bits (268), Expect = 7e-24, Method: Compositional matrix adjust. Identities = 78/263 (29%), Positives = 125/263 (47%), Gaps = 23/263 (8%) Query: 146 LATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACEFDAMG 205 LA I G +++S+AC++S+ I + I++G D GG + L FD++ Sbjct: 157 LARYLAIEGPAFTLSTACSSSSRAIISGQRLIEMGLVDAAIVGGADTLSRMPINGFDSLE 216 Query: 206 ALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVVEELEHALARGAHIYAEIVGYGATSD 265 +LS + + R G I ++++ +A ++G G +SD Sbjct: 217 SLSPTLCE-------PFCQDRQGITIGEASTLLLLTREPQPIA--------LLGVGESSD 261 Query: 266 GADMVA--PSGEGAVRCMKMAMHGV---DTPIDYLNSHGTSTPVGDVKELAAIREVFGDK 320 M A P G GA+ + MA+ I Y+N HGT T + D E I ++FG+ Sbjct: 262 AWHMSAPHPEGRGAIAAINMALRKAGISPAEIGYINLHGTGTKLNDQMESIVINQIFGEN 321 Query: 321 SPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSINIEE--LDEQAAGLNIVTETT 378 +P S+TK +TGH+LGAAG EA L+L P+ + +D ++T++ Sbjct: 322 TPC-SSTKYLTGHTLGAAGACEAGLCWLLLTRHLPLPAQDFTRSGIDIALPACGLLTQSQ 380 Query: 379 DRELTTVMSNSFGFGGTNATLVM 401 E VMSNSF FGG N +L++ Sbjct: 381 PLEKPIVMSNSFAFGGNNTSLIL 403 >4OQJ-A nrPDB Length = 845 Score = 92.4 bits (228), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 70/211 (33%), Positives = 105/211 (49%), Gaps = 21/211 (9%) Query: 214 TPEKASRTYDAHRDGFVIAGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGAD---MV 270 +P+ R +DA G VI G G VV++ L ALA G ++A I G +DG+D Sbjct: 239 SPDGHCRAFDAKAQGTVIGNGVGAVVLKRLSDALADGDTVHAVIKGTAVNNDGSDKTGYT 298 Query: 271 APSGEGAVRCMKMAMHGVDT---PIDYLNSHGTSTPVGDVKELAAIREVFGDK------- 320 APS +G + A D + Y+ +HGT+TP+GD E+AA+ + F + Sbjct: 299 APSVQGQAAVVAEAQEIADVGPETVSYVEAHGTATPLGDPIEVAALNQAFNREGAALAPG 358 Query: 321 SPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSINIE----ELDEQAAGLNIVTE 376 S A+ + K GH AAG+ I ++LML H + PS+ E E+D A + TE Sbjct: 359 SCALGSVKTNVGHLDTAAGMAGLIKTILMLRHRTLVPSLCFEAPNPEIDFAAGPFYVGTE 418 Query: 377 TTDRELTTVMS----NSFGFGGTNATLVMRK 403 T + +SFG GGTNA +++ + Sbjct: 419 TKEWPAGPTPRRAGVSSFGIGGTNAHVIVEE 449 >4CW4-A nrPDB Length = 639 Score = 75.1 bits (183), Expect = 5e-14, Method: Compositional matrix adjust. Identities = 78/275 (28%), Positives = 124/275 (45%), Gaps = 29/275 (10%) Query: 154 GVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACE-FDAMGALSTK-- 210 G+ SI+ ACAT + + ++ I G+ +V G E E + AMGAL+T+ Sbjct: 277 GMTGSITGACATFLYNLQKGIDVITSGQARVVIVGNSEAPILPECIEGYSAMGALATEEG 336 Query: 211 ------YNDTP-EKASRTYDAHRDGFVIAGGGGMVVVEELEHALARGAHIYAEIVGYGAT 263 +D +ASR + GF +A VV+ + E AL GA I+ + Sbjct: 337 LRLIEGRDDVDFRRASRPF-GENCGFTLAESSQYVVLMDDELALRLGADIHGAVTDVFIN 395 Query: 264 SDG-ADMVAPSGEGAVRCMKMAMH------GVDT--PIDYLNSHGTSTPVGDVKE---LA 311 +DG ++ G G + A+ G+DT ++++HG+STP V E L Sbjct: 396 ADGFKKSISAPGPGNYLTVAKAVASAVQIVGLDTVRHASFVHAHGSSTPANRVTESEILD 455 Query: 312 AIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSINI-----EELDE 366 + FG ++A KA GHSL A + I +L ++G I P I +++ + Sbjct: 456 RVASAFGIDGWPVTAVKAYVGHSLATASADQLISALGTFKYG-ILPGIKTIDKVADDVHQ 514 Query: 367 QAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVM 401 Q ++ D+ L NS GFGG NA+ V+ Sbjct: 515 QRLSISNRDMRQDKPLEVCFINSKGFGGNNASGVV 549 >1TQY-B nrPDB Length = 415 Score = 74.7 bits (182), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 96/417 (23%), Positives = 179/417 (42%), Gaps = 28/417 (6%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK-LDTTGLI 60 K +ITG+G+V+ G +++ +GR G+ S + + G + I Sbjct: 9 KSVLITGVGVVAPNGLGLAPYWSAVLDGRHGLGPVTRFDVSRYPATLAGQIDDFHAPDHI 68 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRF--QVFGAD 118 +++ ++ A + + A+ DA PE+ + +G++ + G F + F Sbjct: 69 PGRLLPQTDPSTRLALTAADWALQDAKADPESLTDY-DMGVVTANACGGFDFTHREFRKL 127 Query: 119 AMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQ 178 GP+ + + A+ +G ++ + G + ++ + A +G+A I+ Sbjct: 128 WSEGPKSVSVYESFAWFYAVNTG---QISIRHGMRGPSSALVAEQAGGLDALGHARRTIR 184 Query: 179 LGKQDIVFAGGGEEL-CWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGM 237 G +V G L W + A G +ST + P++A +D G+V GG + Sbjct: 185 RGTPLVVSGGVDSALDPWGWVSQI-ASGRISTATD--PDRAYLPFDERAAGYVPGEGGAI 241 Query: 238 VVVEELEHALARGAH-IYAEIVGYGATSDGADMVAPSGE--GAVRCMKMAMHGVDT---P 291 +V+E+ A ARG H Y E+ G +T D A SG G R +++A++ T Sbjct: 242 LVLEDSAAAEARGRHDAYGELAGCASTFDPAPG---SGRPAGLERAIRLALNDAGTGPED 298 Query: 292 IDYLNSHGTSTPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLE 351 +D + + G P D E AI VFG + ++ K TG G + + +L+ L Sbjct: 299 VDVVFADGAGVPELDAAEARAIGRVFGREGVPVTVPKTTTGRLYSGGGPLDVVTALMSLR 358 Query: 352 HGFIAPSINIEELDEQAAGLNIV----TETTDRELTTVMSNSFGFGGTNATLVMRKL 404 G IAP+ + + + G+++V T R + +GF N+ V+R+ Sbjct: 359 EGVIAPTAGVTSVPRE-YGIDLVLGEPRSTAPRTALVLARGRWGF---NSAAVLRRF 411 >5ENY-A nrPDB Length = 764 Score = 70.5 bits (171), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 87/298 (29%), Positives = 138/298 (46%), Gaps = 35/298 (11%) Query: 135 TKAMASGVSACLAT---PF--KIHGVNYSISSACATSAHCIGNAV-EQIQLGKQ-DIVFA 187 ++A A+G S +A P+ + G I +AC++S +G + Q + K+ D+ Sbjct: 309 SRANATGNSFAIAAARIPYFLNLKGPAIPIDTACSSS--LVGTHLARQALINKEIDMALV 366 Query: 188 GG-GEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVVEELEHA 246 GG L E G LS P+ + +D +GFV G G +V++ L+ A Sbjct: 367 GGVSLYLTPESYMSMCEAGMLS------PDGQCKAFDNGANGFVPGEGAGALVLKRLKDA 420 Query: 247 LARGAHIYAEIVGYGATSDGAD--MVAPSGEGAVRCMK--MAMHGVDTP-IDYLNSHGTS 301 A HIY I+G G DG + APS + + + +G+ I Y+ HGT Sbjct: 421 EADRDHIYGIIIGSGINQDGKTNGITAPSAKSQMDLERDIYETYGIHPESISYVEMHGTG 480 Query: 302 TPVGDVKELAAIREVFGDKSP-----AISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIA 356 T GD EL A+ VF +K+ AI + K+ GH+ AAGV LL + H + Sbjct: 481 TKQGDPIELEALSTVFQEKTDKKQFCAIGSVKSNIGHTSAAAGVAGVQKVLLCMNHKTLV 540 Query: 357 PSINI----EELDEQAAGLNIVT-----ETTDRELTTVMSNSFGFGGTNATLVMRKLK 405 P++N E + + + L + T ET D + +SFG+ GTNA +V+ + + Sbjct: 541 PTLNFTTPNEHFEFEHSPLYVNTELKPWETADGKPRRACVSSFGYSGTNAHIVIEEYQ 598 >3SS6-A nrPDB Length = 394 Score = 34.7 bits (78), Expect = 0.076, Method: Compositional matrix adjust. Identities = 19/51 (37%), Positives = 27/51 (52%) Query: 143 SACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEEL 193 +A LA F Y+I C++ I +A QIQLG ++V AGG E + Sbjct: 71 TAALAAGFPDTVTGYTIQRQCSSGMQAIMSAAMQIQLGVSEVVVAGGVEAM 121 >2HF8-A nrPDB Length = 226 Score = 30.4 bits (67), Expect = 1.6, Method: Compositional matrix adjust. Identities = 30/137 (21%), Positives = 59/137 (43%), Gaps = 22/137 (16%) Query: 163 CATSAHCIGNAVEQIQLGKQDIVFAGG-GEELC---WEMACEFDAMGALSTKYNDTPEKA 218 C AH +G+A+E + L + D++F G +C +++ + +T+ +DT EK Sbjct: 100 CHLDAHLVGHALEDLNLDEIDLLFIENVGNLICPADFDLGTHKRIVVISTTEGDDTIEKH 159 Query: 219 SRTYDAHRDGFVIAGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAV 278 I ++V+ +++ A A GA I + A + P E + Sbjct: 160 PG----------IMKTADLIVINKIDLADAVGADIK-------KMENDAKRINPDAEVVL 202 Query: 279 RCMKMAMHGVDTPIDYL 295 +K M G D ++++ Sbjct: 203 LSLK-TMEGFDKVLEFI 218 >4B3J-C nrPDB Length = 403 Score = 28.5 bits (62), Expect = 4.9, Method: Compositional matrix adjust. Identities = 17/64 (26%), Positives = 31/64 (48%), Gaps = 1/64 (1%) Query: 143 SACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCW-EMACEF 201 +A LA+ + ++ CA+ + A ++++ G D+V AGG E + M + Sbjct: 72 AAVLASGMPVTSGGVQLNRFCASGLEAVNTAAQKVRSGWDDLVLAGGVESMSRVPMGSDG 131 Query: 202 DAMG 205 AMG Sbjct: 132 GAMG 135 >4E1L-A nrPDB Length = 395 Score = 28.1 bits (61), Expect = 7.0, Method: Compositional matrix adjust. Identities = 11/39 (28%), Positives = 20/39 (51%) Query: 157 YSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCW 195 Y+++ C + + A + I G+ D+V AGG E + Sbjct: 85 YTVNKLCGSGLKSVQLAAQSITSGENDVVIAGGTENMSQ 123 >3SZE-A nrPDB Length = 968 Score = 27.7 bits (60), Expect = 8.9, Method: Compositional matrix adjust. Identities = 20/74 (27%), Positives = 31/74 (41%), Gaps = 9/74 (12%) Query: 162 ACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRT 221 A + G + + +D++F GGG+ L + FD GA +ND +T Sbjct: 270 ATIENGKLTGTGSDTTDIKNKDLIFTGGGDIL---LKSSFDN-GAGGLVFND-----KKT 320 Query: 222 YDAHRDGFVIAGGG 235 Y + D F G G Sbjct: 321 YRVNGDDFTFKGAG 334 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 2BZ4-A nrPDB 553 e-158 4LS7-A nrPDB 537 e-153 4XOX-A nrPDB 531 e-151 3OYT-A nrPDB 527 e-150 1E5M-A nrPDB 522 e-148 3O04-A nrPDB 510 e-145 2GQD-A nrPDB 508 e-144 4JPF-A nrPDB 508 e-144 1J3N-A nrPDB 506 e-144 4JRH-A nrPDB 504 e-143 4R8E-A nrPDB 504 e-143 4QAV-A nrPDB 501 e-142 4JGA-A nrPDB 494 e-140 3U0E-A nrPDB 489 e-139 3HO9-A nrPDB 486 e-138 3KZU-A nrPDB 482 e-136 1OXH-A nrPDB 476 e-134 3E60-A nrPDB 473 e-134 2IX4-A nrPDB 468 e-132 2IWZ-A nrPDB 467 e-132 4DDO-A nrPDB 445 e-125 2GP6-A nrPDB 420 e-118 1TQY-A nrPDB 415 e-116 5W2O-A nrPDB 409 e-115 1TQY-B nrPDB 353 6e-98 6QSP-A nrPDB 269 1e-72 5ENY-A nrPDB 256 2e-68 4CW4-A nrPDB 247 8e-66 4OQJ-A nrPDB 230 1e-60 Sequences not found previously or not previously below threshold: 2EBD-A nrPDB 46 4e-05 4DD5-A nrPDB 45 4e-05 4N44-A nrPDB 44 1e-04 4NZS-A nrPDB 43 2e-04 4E1L-A nrPDB 42 3e-04 5ZQZ-B nrPDB 42 7e-04 4WYS-A nrPDB 40 0.002 6ARG-A nrPDB 40 0.002 2IBU-A nrPDB 40 0.003 3SS6-A nrPDB 39 0.004 2AJ9-A nrPDB 39 0.004 4EWP-A nrPDB 38 0.006 6ESQ-A nrPDB 37 0.012 3GOA-A nrPDB 37 0.014 4C2K-A nrPDB 37 0.015 3SVK-A nrPDB 36 0.027 4BI9-A nrPDB 36 0.034 6BN2-A nrPDB 35 0.041 4B3J-C nrPDB 35 0.044 5XYJ-B nrPDB 35 0.046 5BNS-A nrPDB 35 0.059 4NHD-A nrPDB 35 0.073 5LP7-H nrPDB 35 0.082 1WL4-A nrPDB 35 0.087 5CBQ-A nrPDB 34 0.10 4YLT-A nrPDB 34 0.11 6HRV-A nrPDB 34 0.14 1NL7-A nrPDB 34 0.15 5M3K-C nrPDB 33 0.19 4X0O-A nrPDB 33 0.19 4KR4-A nrPDB 33 0.24 3LS2-A nrPDB 33 0.26 2WUA-A nrPDB 33 0.32 1WDK-C nrPDB 33 0.32 1UB7-A nrPDB 33 0.34 3LM6-A nrPDB 32 0.40 5VXG-A nrPDB 32 0.47 3MW8-A nrPDB 32 0.65 2JB5-L nrPDB 32 0.65 3IL3-A nrPDB 32 0.69 6BJB-A nrPDB 32 0.70 6BJA-A nrPDB 31 0.82 4DFE-A nrPDB 31 0.93 3JC8-Ba nrPDB 31 1.0 1D4E-A nrPDB 31 1.1 4O9A-A nrPDB 30 1.4 2C7Y-A nrPDB 30 1.4 5C4I-A nrPDB 30 1.4 5B8I-B nrPDB 30 1.4 1PXT-A nrPDB 30 1.7 5YO9-A nrPDB 30 2.0 5LNQ-A nrPDB 30 2.2 3CN7-A nrPDB 30 2.3 2PP0-A nrPDB 30 2.4 5BQS-A nrPDB 30 2.5 1GGZ-A nrPDB 30 2.5 2Z0F-A nrPDB 30 2.9 1ULQ-A nrPDB 29 3.3 3IL7-A nrPDB 29 3.5 6ESQ-I nrPDB 29 4.6 5UTH-A nrPDB 28 5.2 5XN6-C nrPDB 28 5.8 4MTS-A nrPDB 28 6.6 4KXR-A nrPDB 28 7.3 3TL2-A nrPDB 28 8.6 >2BZ4-A nrPDB Length = 418 Score = 553 bits (1424), Expect = e-158, Method: Composition-based stats. Identities = 405/406 (99%), Positives = 405/406 (99%) Query: 1 MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLI 60 MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLI Sbjct: 13 MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLI 72 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM 120 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM Sbjct: 73 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM 132 Query: 121 RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG 180 RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG Sbjct: 133 RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG 192 Query: 181 KQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVV 240 KQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVV Sbjct: 193 KQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVV 252 Query: 241 EELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDTPIDYLNSHGT 300 EELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDTPIDYLNS GT Sbjct: 253 EELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDTPIDYLNSQGT 312 Query: 301 STPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSIN 360 STPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSIN Sbjct: 313 STPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSIN 372 Query: 361 IEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLKD 406 IEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLKD Sbjct: 373 IEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLKD 418 >4LS7-A nrPDB Length = 426 Score = 537 bits (1383), Expect = e-153, Method: Composition-based stats. Identities = 163/413 (39%), Positives = 229/413 (55%), Gaps = 13/413 (3%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK-LDTTGLI 60 KR V+TGLG +S +GN+ + G SGI + + V +K + + Sbjct: 17 KRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAEEYPAKVAAELKDFNVEDYM 76 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM 120 D+K R M + YA ++ + A+ DA L+ PRVG+ GSG G + + Sbjct: 77 DKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIA-PRVGVWVGSGIGGLET-LESQFEI 134 Query: 121 RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG 180 +G + V P+ V + + ++ GVN +ACAT + IG+A + IQ G Sbjct: 135 FLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCTVTACATGTNSIGDAFKVIQRG 194 Query: 181 KQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVV 239 D++ GG E M+ F A ALST N P+ ASR +D +RDGFV+ G G++V Sbjct: 195 DADVMVTGGTEAPLTRMSFAGFSANKALST--NPDPKTASRPFDKNRDGFVMGEGAGIIV 252 Query: 240 VEELEHALARGAHIYAEIVGYGATSDGADMVAP--SGEGAVRCMKMAMHGV---DTPIDY 294 +EELEHALARGA IY EIVGYG+T D + AP GEG R M+ A+ IDY Sbjct: 253 LEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDGEGGARAMQEAIKDAGIAPEEIDY 312 Query: 295 LNSHGTSTPVGDVKELAAIREVFGDKSP--AISATKAMTGHSLGAAGVQEAIYSLLMLEH 352 +N+HGTST D E AI+ VFG+ + A+S+TK+MTGH LGAAG EAI+S+L ++ Sbjct: 313 INAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSSTKSMTGHLLGAAGGIEAIFSILAIKE 372 Query: 353 GFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLK 405 G I P+INI+ DE+ + E +EL V+SNS GFGG NATL+ +K + Sbjct: 373 GVIPPTINIQTPDEECDLDYVPDEARRQELNYVLSNSLGFGGHNATLIFKKYQ 425 >4XOX-A nrPDB Length = 404 Score = 531 bits (1369), Expect = e-151, Method: Composition-based stats. Identities = 304/405 (75%), Positives = 343/405 (84%), Gaps = 3/405 (0%) Query: 1 MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLI 60 MKR VITG+GI+SSIGNN +EVLASL+ G+SGIT S++ K+ G+RS VWG++K++ I Sbjct: 1 MKRVVITGMGIISSIGNNVEEVLASLKAGKSGITASEQFKEHGLRSQVWGDLKINPEEHI 60 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM 120 DRK +RFM DA+ YA+LS+EQAIADAGL+PE N R G++AGSGG S QV D Sbjct: 61 DRKQMRFMGDAAAYAYLSLEQAIADAGLTPEQVSN-DRTGIVAGSGGASSENQVIAVDTQ 119 Query: 121 RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG 180 R +G+K VGPY+V + M+S VSACLATPFKI GVNYSISSACATSAHCIGNAVE IQLG Sbjct: 120 R-EKGVKRVGPYMVPRTMSSTVSACLATPFKIRGVNYSISSACATSAHCIGNAVELIQLG 178 Query: 181 KQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVV 240 KQDIVFAGGGEEL W FDAMGALSTKYN+TPEKASRTYDA RDGFVI+GGGGMVVV Sbjct: 179 KQDIVFAGGGEELYWSQTMMFDAMGALSTKYNETPEKASRTYDADRDGFVISGGGGMVVV 238 Query: 241 EELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDTPIDYLNSHGT 300 EELEHALARGA IY EIVGYGATSDG DMVAPSGEGA+RCMKMAM GVD IDY+N+HGT Sbjct: 239 EELEHALARGAKIYGEIVGYGATSDGYDMVAPSGEGAIRCMKMAMQGVD-KIDYINTHGT 297 Query: 301 STPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSIN 360 STPVGDVKEL AI+EVFG SPAISATKAMTGH+LGAAGV EAIYS LML HGFIAPSIN Sbjct: 298 STPVGDVKELGAIQEVFGGNSPAISATKAMTGHALGAAGVHEAIYSTLMLHHGFIAPSIN 357 Query: 361 IEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLK 405 I+ LDE A GL+IVTE ++ELTTVMSNSFGFGGTNATLV++K + Sbjct: 358 IDTLDEAAQGLDIVTELREQELTTVMSNSFGFGGTNATLVIKKYQ 402 >3OYT-A nrPDB Length = 410 Score = 527 bits (1357), Expect = e-150, Method: Composition-based stats. Identities = 347/407 (85%), Positives = 377/407 (92%), Gaps = 3/407 (0%) Query: 1 MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKL--DTTG 58 MKRAVITGLGIVSSIGNNQQEVLASL+EGRSGITF+QE KD+GMRSHVWG+VKL + Sbjct: 4 MKRAVITGLGIVSSIGNNQQEVLASLQEGRSGITFAQEFKDAGMRSHVWGDVKLQSEPKD 63 Query: 59 LIDRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGAD 118 LIDRKV+RFMSDASIYA+L+M++AIAD+GLS ++ +N R GL+ GSGGGSPR QV G+D Sbjct: 64 LIDRKVLRFMSDASIYAYLAMQEAIADSGLS-DSQVSNFRSGLVVGSGGGSPRNQVAGSD 122 Query: 119 AMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQ 178 AMR PRGLK VGPY+VTKAMASGVSACLATPFKI GVNYSISSACATSAHCIG+A+E IQ Sbjct: 123 AMRTPRGLKGVGPYMVTKAMASGVSACLATPFKIKGVNYSISSACATSAHCIGHALELIQ 182 Query: 179 LGKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMV 238 LGKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTP KASRTYD RDGFVIAGGGGMV Sbjct: 183 LGKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPAKASRTYDQDRDGFVIAGGGGMV 242 Query: 239 VVEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDTPIDYLNSH 298 VVEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCM+MAM GVDTPIDY+N H Sbjct: 243 VVEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMQMAMAGVDTPIDYMNVH 302 Query: 299 GTSTPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPS 358 GTSTPVGDVKEL AIREVFG+ +PAIS+TKAMTGHSLGAAGV EAI+SLLM+EHGFIAPS Sbjct: 303 GTSTPVGDVKELGAIREVFGNNTPAISSTKAMTGHSLGAAGVHEAIFSLLMVEHGFIAPS 362 Query: 359 INIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLK 405 INI+ LDEQA G+NI+TETT RELTTVMSNSFGFGGTNATLVMRK + Sbjct: 363 INIDNLDEQAQGMNIITETTQRELTTVMSNSFGFGGTNATLVMRKYQ 409 >1E5M-A nrPDB Length = 416 Score = 522 bits (1345), Expect = e-148, Method: Composition-based stats. Identities = 144/413 (34%), Positives = 213/413 (51%), Gaps = 12/413 (2%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK-LDTTGLI 60 KR V+TGLG ++ IGN Q+ L EGR+GI S G VK D T + Sbjct: 7 KRVVVTGLGAITPIGNTLQDYWQGLMEGRNGIGPITRFDASDQACRFGGEVKDFDATQFL 66 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM 120 DRK + M +A + +QAI DA L N +G++ G+G G + + Sbjct: 67 DRKEAKRMDRFCHFAVCASQQAINDAKLVINEL-NADEIGVLIGTGIGGLKVLEDQQTIL 125 Query: 121 RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG 180 +G P+++ +A+ S A G N +ACA ++ IG+A +Q G Sbjct: 126 LD-KGPSRCSPFMIPMMIANMASGLTAINLGAKGPNNCTVTACAAGSNAIGDAFRLVQNG 184 Query: 181 KQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVV 239 + GG E ++ F + ALS + ND P ASR +D RDGFV+ G G+++ Sbjct: 185 YAKAMICGGTEAAITPLSYAGFASARALSFR-NDDPLHASRPFDKDRDGFVMGEGSGILI 243 Query: 240 VEELEHALARGAHIYAEIVGYGATSDGADMVA--PSGEGAVRCMKMAMHGV---DTPIDY 294 +EELE ALARGA IY E+VGY T D + A P G GA R + A+ + Y Sbjct: 244 LEELESALARGAKIYGEMVGYAMTCDAYHITAPVPDGRGATRAIAWALKDSGLKPEMVSY 303 Query: 295 LNSHGTSTPVGDVKELAAIREVFGDKSP--AISATKAMTGHSLGAAGVQEAIYSLLMLEH 352 +N+HGTSTP DV E AI++ G+ + A+S+TK+MTGH LG +G EA+ +++ + Sbjct: 304 INAHGTSTPANDVTETRAIKQALGNHAYNIAVSSTKSMTGHLLGGSGGIEAVATVMAIAE 363 Query: 353 GFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLK 405 + P+IN+E D + + ++ + +SNSFGFGG N TL +K + Sbjct: 364 DKVPPTINLENPDPECDLDYVPGQSRALIVDVALSNSFGFGGHNVTLAFKKYQ 416 >3O04-A nrPDB Length = 413 Score = 510 bits (1314), Expect = e-145, Method: Composition-based stats. Identities = 163/414 (39%), Positives = 234/414 (56%), Gaps = 13/414 (3%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK-LDTTGLI 60 +R V+TG+G V+ IGN+ + + ++G +G+ L + +K D + Sbjct: 4 RRVVVTGIGAVTPIGNDAETSWENAKKGVNGVAKMTRLNPDDFPVKIAAELKDFDVEKYL 63 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM 120 ++K R M + YA S E A+ D+GL + N RVG+ GSG G + Sbjct: 64 EKKEARKMDRFTHYAIASAEMAVQDSGLVID-DSNANRVGVWIGSGIGGMETFETQYEIF 122 Query: 121 RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG 180 RG + V P+ V + S ++ F G+N + +ACAT+ + IG+A + I+ G Sbjct: 123 LN-RGHRRVSPFFVPMMIPDMGSGQVSIRFGAKGINSTTVTACATATNSIGDAFKVIERG 181 Query: 181 KQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVV 239 D + GG E +M+ F A ALS N PE A R +D RDGF+I G G+V+ Sbjct: 182 DADAMITGGAEAPITKMSLAGFTANKALS--LNPDPETACRPFDKDRDGFIIGEGAGIVI 239 Query: 240 VEELEHALARGAHIYAEIVGYGATSDGADMVAPS--GEGAVRCMKMAMHGV---DTPIDY 294 +EE EHA ARGA IYAEIVGYGAT D + AP+ GEGA R MKMA+ +DY Sbjct: 240 LEEYEHAKARGAKIYAEIVGYGATGDAYHITAPAPNGEGAARAMKMAIDDAGLTPDKVDY 299 Query: 295 LNSHGTSTPVGDVKELAAIREVFGDKS--PAISATKAMTGHSLGAAGVQEAIYSLLMLEH 352 +N+HGTSTP D E AI+ VFG+ + AIS+TK+MTGH+LGA+G EAI++LL + Sbjct: 300 INAHGTSTPYNDEYETQAIKTVFGEHAKKLAISSTKSMTGHTLGASGGIEAIFALLTIRD 359 Query: 353 GFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLKD 406 IAP+I+++ DE + E + + V+SNSFGFGG NATLV ++++D Sbjct: 360 NIIAPTIHLKNQDEVCDLDYVPNEAREANVNVVISNSFGFGGHNATLVFKRIED 413 >2GQD-A nrPDB Length = 437 Score = 508 bits (1309), Expect = e-144, Method: Composition-based stats. Identities = 158/414 (38%), Positives = 221/414 (53%), Gaps = 15/414 (3%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK-LDTTGLI 60 KR VITG+G +S IGN+ + + +G +GI + H+ G +K + I Sbjct: 28 KRVVITGMGALSPIGNDVKTTWENALKGVNGIDKITRIDTEPYSVHLAGELKNFNIEDHI 87 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPR-FQVFGADA 119 D+K R M + YA ++ +A+ DA L R+G+ GSG G F++ Sbjct: 88 DKKEARRMDRFTQYAIVAAREAVKDAQLDINENTA-DRIGVWIGSGIGGMETFEIAHKQL 146 Query: 120 MRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQL 179 M +G + V P+ V + + ++ G N + +ACAT + IG A + +Q Sbjct: 147 M--DKGPRRVSPFFVPMLIPDMATGQVSIDLGAKGPNGATVTACATGTNSIGEAFKIVQR 204 Query: 180 GKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMV 238 G D + GG E MA F A ALST ND E A R + RDGFV+ G G++ Sbjct: 205 GDADAMITGGTEAPITHMAIAGFSASRALST--NDDIETACRPFQEGRDGFVMGEGAGIL 262 Query: 239 VVEELEHALARGAHIYAEIVGYGATSDGADMVAP--SGEGAVRCMKMAMHGV---DTPID 293 V+E LE A ARGA+IYAEIVGYG T D + AP GEG R M+ AM + Sbjct: 263 VIESLESAQARGANIYAEIVGYGTTGDAYHITAPAPEGEGGSRAMQAAMDDAGIEPKDVQ 322 Query: 294 YLNSHGTSTPVGDVKELAAIREVFGD--KSPAISATKAMTGHSLGAAGVQEAIYSLLMLE 351 YLN+HGTSTPVGD+ E+ AI+ FG+ K +S+TK+MTGH LGA G EAI+S L ++ Sbjct: 323 YLNAHGTSTPVGDLNEVKAIKNTFGEAAKHLKVSSTKSMTGHLLGATGGIEAIFSALSIK 382 Query: 352 HGFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLK 405 +AP+I+ D + + E D ++T MSNS GFGG NA LV +K + Sbjct: 383 DSKVAPTIHAVTPDPECDLDIVPNEAQDLDITYAMSNSLGFGGHNAVLVFKKFE 436 >4JPF-A nrPDB Length = 436 Score = 508 bits (1308), Expect = e-144, Method: Composition-based stats. Identities = 164/414 (39%), Positives = 234/414 (56%), Gaps = 12/414 (2%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK-LDTTGLI 60 +R VITG+G++S +G + + GRSGI + + S + G+VK + + Sbjct: 26 RRVVITGMGMLSPLGLDVPSSWEGILAGRSGIAPIEHMDLSAYSTRFGGSVKGFNVEEYL 85 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM 120 K R + Y + QA+ D+GL N R+G+ GSG G ++ Sbjct: 86 SAKEARKLDLFIQYGLAASFQAVRDSGLEV-TDANRERIGVSMGSGIGGLTNIENNCRSL 144 Query: 121 RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG 180 +G + + P+ V ++ + VS L+ + G NY++++AC T H IG A I G Sbjct: 145 F-EQGPRRISPFFVPGSIINMVSGFLSIHLGLQGPNYALTTACTTGTHSIGMAARNIAYG 203 Query: 181 KQDIVFAGGGE-ELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVV 239 + D++ AGG E C F A ALST+ ND P +ASR +D RDGFV++ G G +V Sbjct: 204 EADVMVAGGSEMAACGLGLGGFGAARALSTR-NDEPTRASRPWDRDRDGFVLSDGSGALV 262 Query: 240 VEELEHALARGAHIYAEIVGYGATSDGADMVAPS--GEGAVRCMKMAMHGV---DTPIDY 294 +EELEHA ARGA IYAE+VG+G + D M AP G GA RCMK A+ +DY Sbjct: 263 LEELEHARARGARIYAELVGFGMSGDAFHMTAPPEDGAGAARCMKNALRDAGLDPRQVDY 322 Query: 295 LNSHGTSTPVGDVKELAAIREVFGDKSPAI--SATKAMTGHSLGAAGVQEAIYSLLMLEH 352 +N+HGTSTP GD+ E+AA++ VFG+ + A+ S+TK+MTGH LGAAG EAI+S+L L Sbjct: 323 INAHGTSTPAGDIAEIAAVKSVFGEHAHALSMSSTKSMTGHLLGAAGAVEAIFSVLALRD 382 Query: 353 GFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLKD 406 P+IN++ DE + E R++ +SNSFGFGGTN TLV R+ D Sbjct: 383 QVAPPTINLDNPDEGCDLDLVAHEAKPRKIDVALSNSFGFGGTNGTLVFRRFAD 436 >1J3N-A nrPDB Length = 408 Score = 506 bits (1304), Expect = e-144, Method: Composition-based stats. Identities = 158/413 (38%), Positives = 235/413 (56%), Gaps = 14/413 (3%) Query: 1 MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLI 60 M+R V+TGLG ++ IG Q+ + G+SG+ S + + V +D + Sbjct: 1 MRRVVVTGLGALTPIGVGQEAFHKAQLAGKSGVRPITRFDASALPVRIAAEVDVDPGAYL 60 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPR-FQVFGADA 119 DRK +R + YA ++ + A+ DAGL PE + RVG + G+G G ++ Sbjct: 61 DRKELRRLDRFVQYALIAAQLALEDAGLKPEDL-DPERVGTLVGTGIGGMETWEAQSRVF 119 Query: 120 MRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQL 179 + RG + P+ + +A+ SA +A + G + ++ +ACAT A +G+A+ IQL Sbjct: 120 L--ERGPNRISPFFIPMMIANMASAHIAMRYGFTGPSSTVVTACATGADALGSALRMIQL 177 Query: 180 GKQDIVFAGGGEELCWEMAC-EFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMV 238 G+ D+V AGG E MA F M ALST+ N+ PEKASR + RDGFV+ G G++ Sbjct: 178 GEADLVLAGGTEAAITPMAIGAFAVMRALSTR-NEEPEKASRPFTLSRDGFVMGEGAGVL 236 Query: 239 VVEELEHALARGAHIYAEIVGYGATSDGADMVA--PSGEGAVRCMKMAMHG---VDTPID 293 V+E EHA RGA IYAE+VG+G ++D + P G+GA M A+ + Sbjct: 237 VLEAYEHAKKRGARIYAELVGFGRSADAHHITEPHPEGKGAALAMARALKDAGIAPEQVG 296 Query: 294 YLNSHGTSTPVGDVKELAAIREVFGDKS--PAISATKAMTGHSLGAAGVQEAIYSLLMLE 351 Y+N+HGTSTPVGD E+ AI+ VFGD + +S+TK+M GH LGAAG EAI ++ L Sbjct: 297 YINAHGTSTPVGDRAEVLAIKRVFGDHAKRLMVSSTKSMIGHLLGAAGAVEAIATVQALY 356 Query: 352 HGFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKL 404 HG I P+IN+E+ D + L+ V E + ++ +SNSF FGG NA L +++ Sbjct: 357 HGVIPPTINLEDPDPELD-LDFVPEPREAKVDYALSNSFAFGGHNAVLAFKRV 408 >4JRH-A nrPDB Length = 417 Score = 504 bits (1298), Expect = e-143, Method: Composition-based stats. Identities = 152/414 (36%), Positives = 222/414 (53%), Gaps = 14/414 (3%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK-LDTTGLI 60 +R V+TG+G++S +GN + +L G+SGI + + + G VK D + Sbjct: 7 RRVVVTGMGMLSPVGNTVESSWKALLAGQSGIVNIEHFDTTNFSTRFAGLVKGFDCEQYM 66 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM 120 +K R M Y + QA+ D+GL N R+G+ GSG G G A+ Sbjct: 67 SKKDARKMDLFIQYGIAAGIQALEDSGLEVNEE-NAARIGVAIGSGIGGLELIETGHQAL 125 Query: 121 RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG 180 +G + V P+ V + + ++ L+ + G N +IS+AC T H IG+A I G Sbjct: 126 I-EKGPRKVSPFFVPSTIVNMIAGNLSIMRGLRGPNIAISTACTTGLHNIGHAARMIAYG 184 Query: 181 KQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVV 239 D + AGG E+ + F A ALST+ ND P+KASR +D RDGFV+ G G++V Sbjct: 185 DADAMVAGGAEKASTPLGMAGFGAAKALSTR-NDEPQKASRPWDKDRDGFVLGDGAGIMV 243 Query: 240 VEELEHALARGAHIYAEIVGYGATSDGADMVAPS--GEGAVRCMKMAMHGVDT---PIDY 294 +EE EHA ARGA IYAE+VG+G + D M +PS G G M+ AM I Y Sbjct: 244 LEEYEHAKARGAKIYAEVVGFGMSGDAYHMTSPSEDGSGGALAMEAAMRDAGVTGEQIGY 303 Query: 295 LNSHGTSTPVGDVKELAAIREVFGDKSPA---ISATKAMTGHSLGAAGVQEAIYSLLMLE 351 +N+HGTSTP GDV E+ I+ G+ +S+TK+MTGH LGAAG EAI +++ L Sbjct: 304 VNAHGTSTPAGDVAEVKGIKRALGEAGTKQVLVSSTKSMTGHLLGAAGSVEAIITVMSLV 363 Query: 352 HGFIAPSINIEELDEQAAGLNIVTETTDRE-LTTVMSNSFGFGGTNATLVMRKL 404 + P+IN++ +E + E + M NSFGFGGTN +L+ +++ Sbjct: 364 DQMVPPTINLDNPEEGLGVDLVPHVARKVESMEYAMCNSFGFGGTNGSLIFKRM 417 >4R8E-A nrPDB Length = 413 Score = 504 bits (1298), Expect = e-143, Method: Composition-based stats. Identities = 148/413 (35%), Positives = 219/413 (53%), Gaps = 13/413 (3%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK-LDTTGLI 60 +R V+TGLG++S +GN + ++ G+SGI+ S + G VK + I Sbjct: 4 RRVVVTGLGMLSPVGNTVESTWKAVLAGQSGISLIDHFDTSAYATRFAGLVKDFNCEDYI 63 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM 120 RK R M Y + QA+ DAGL + I GG + + Sbjct: 64 SRKDARKMDAFIQYGVAAGMQAMQDAGLDITEANASRIGAAIGSGIGGLGLIEENHTALV 123 Query: 121 RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG 180 G G + + P+ V + + ++ L + + G + SI++AC + H IG+A I Sbjct: 124 NG--GPRKISPFFVPSTIVNMIAGHLTIMYGLRGPSISIATACTSGVHNIGHAARIIAYN 181 Query: 181 KQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVV 239 D++ AGG E+ + F A ALST+ ND P+ ASR +D RDGFV+ G GM+V Sbjct: 182 DADVMVAGGAEKASTPLGVGGFGAARALSTR-NDNPQAASRPWDKDRDGFVLGDGAGMMV 240 Query: 240 VEELEHALARGAHIYAEIVGYGATSDGADMVAPS--GEGAVRCMKMAMHGVD---TPIDY 294 +EE EHA RGA IYAE+VG+G +SD M +P G GA M A+ + I Y Sbjct: 241 LEEYEHAKKRGAKIYAEVVGFGMSSDAYHMTSPPEDGSGAALAMVNALRDAGITTSQIGY 300 Query: 295 LNSHGTSTPVGDVKELAAIREVFGDKSPA--ISATKAMTGHSLGAAGVQEAIYSLLMLEH 352 +N+HGTSTP GD E A++ VFG+ + +S+TK+MTGH LGAAG E+I+++L L Sbjct: 301 INAHGTSTPAGDKAETQAVKSVFGEDAYKVMVSSTKSMTGHLLGAAGAVESIFTVLALRD 360 Query: 353 GFIAPSINIEELDEQAAGLNIVTETTD-RELTTVMSNSFGFGGTNATLVMRKL 404 I +IN++ DE + + +++ + NSFGFGGTN +LV RK+ Sbjct: 361 QAIPATINLDNPDEGCDLDYVPHDARQVKDMEYTLCNSFGFGGTNGSLVFRKV 413 >4QAV-A nrPDB Length = 415 Score = 501 bits (1290), Expect = e-142, Method: Composition-based stats. Identities = 171/414 (41%), Positives = 230/414 (55%), Gaps = 13/414 (3%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK-LDTTGLI 60 +R VITGLG VS +GN E +L G+SGI S + S V G V+ D I Sbjct: 4 RRVVITGLGQVSPVGNTVAEAWDTLLAGKSGIGAITRFDASDINSRVAGEVRGFDIGQYI 63 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGS-PRFQVFGADA 119 K R M Y + QAIAD+GL + R+G+ GSG G P +V G Sbjct: 64 SAKEARRMDVFIHYGIAAALQAIADSGLDDVENLDKDRIGVNIGSGIGGLPSIEVTGKAV 123 Query: 120 MRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQL 179 + G G + + P+ + ++ + +S + G +Y + SAC T AH IGN+ I+ Sbjct: 124 IEG--GARKINPFFIPGSLINLISGHVTILKGYRGPSYGMVSACTTGAHAIGNSARLIKY 181 Query: 180 GKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMV 238 G DI+ AGG E + F AM ALST+ ND P ASR +D RDGFVI G G++ Sbjct: 182 GDADIMVAGGAEGAISTLGVGGFAAMKALSTR-NDDPATASRPWDKGRDGFVIGEGAGIL 240 Query: 239 VVEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGV---DTPIDYL 295 V+EELEHA RGA IYAEIVG+G +SD + AP+ EG + A+ +DY+ Sbjct: 241 VLEELEHAKKRGAKIYAEIVGFGMSSDAYHITAPNEEGPALAVTRALKDAGINPEDVDYV 300 Query: 296 NSHGTSTPVGDVKELAAIREVFGDKSPA--ISATKAMTGHSLGAAGVQEAIYSLLMLEHG 353 N+HGTSTP+GD E A++ FG+ + +S+TK+MTGH LGAAG EA+YS+L + G Sbjct: 301 NAHGTSTPLGDANETKALKRAFGEHAYKTVVSSTKSMTGHLLGAAGGVEAVYSILAIHDG 360 Query: 354 FIAPSINIEELDEQ--AAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLK 405 I P+INI E D + E D E+ +SNSFGFGGTN TLV ++ K Sbjct: 361 KIPPTINIFEQDVEAGCDLDYCANEARDAEIDVAISNSFGFGGTNGTLVFKRFK 414 >4JGA-A nrPDB Length = 437 Score = 494 bits (1273), Expect = e-140, Method: Composition-based stats. Identities = 151/420 (35%), Positives = 229/420 (54%), Gaps = 18/420 (4%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK-------- 53 KR VITGLG+V+ +G N ++ +G SGI E S + + G + Sbjct: 16 KRVVITGLGLVTPVGLNVNSSWKNIVDGVSGIKTITEFDTSKLACKIAGLIDNSEKDGFK 75 Query: 54 -LDTTGLIDRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRF 112 + T D + M Y + +A+ D+G P+ ++ R GLI GSG G + Sbjct: 76 LENFTQADDINRLSKMDKFIHYGVAAATEAVEDSGWLPDDEKSRDRTGLILGSGIGGLKM 135 Query: 113 QVFGADAMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGN 172 + + K V P+ + ++ + +S ++ + G N + +AC+T AH IG+ Sbjct: 136 IEDTSIKLYQENNGK-VSPFFIPASLINLLSGLVSIKYGFSGPNQTAVTACSTGAHAIGD 194 Query: 173 AVEQIQLGKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVI 231 A+ I+ G D++ AGG E + F A AL TKYND P+KASR +D R GFV+ Sbjct: 195 AMRMIKHGYADVMIAGGAEAPVTPVGVAGFVAARALCTKYNDNPKKASRPWDKDRSGFVM 254 Query: 232 AGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVA--PSGEGAVRCMKMAMHGV- 288 G G+VV+EE EHAL RGA +Y E++GYG+T D M A P G GA R M+ AM Sbjct: 255 GEGAGVVVLEEYEHALNRGAKVYGEVIGYGSTGDAYHMTAPHPEGRGAYRAMRDAMLDAT 314 Query: 289 --DTPIDYLNSHGTSTPVGDVKELAAIREVFGDKSPAI--SATKAMTGHSLGAAGVQEAI 344 IDY+N+HGTST +GD ELAA++++F + +P + S+TK+ GH LGAAG E I Sbjct: 315 ITPDMIDYINAHGTSTTLGDGIELAAVQKLFLEANPKVLMSSTKSSIGHLLGAAGSVEFI 374 Query: 345 YSLLMLEHGFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKL 404 +S L + P++N++ ++ + + ++ V+SNSFGFGGTNA+LV++ + Sbjct: 375 FSALAIRDQIAPPTLNLDTPMDEVNIDLVALKAKKTKIDYVLSNSFGFGGTNASLVIKSI 434 >3U0E-A nrPDB Length = 428 Score = 489 bits (1259), Expect = e-139, Method: Composition-based stats. Identities = 246/408 (60%), Positives = 303/408 (74%), Gaps = 5/408 (1%) Query: 1 MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLI 60 M+R V+TG+GIVSSIG+N +EV ASLRE +SGI+ ++E + G R V G +D L+ Sbjct: 22 MRRVVVTGMGIVSSIGSNTEEVTASLREAKSGISRAEEYAELGFRCQVHGAPDIDIESLV 81 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM 120 DR+ +RF + + ++M+QAIADAGL+ E N R G+I GSGG S R V AD Sbjct: 82 DRRAMRFHGRGTAWNHIAMDQAIADAGLTEEEVSN-ERTGIIMGSGGPSTRTIVDSADIT 140 Query: 121 RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG 180 R +G K VGP+ V KAM+S SA LAT FKI G+NYSISSACATS HCIGNA E IQ G Sbjct: 141 R-EKGPKRVGPFAVPKAMSSTASATLATFFKIKGINYSISSACATSNHCIGNAYEMIQYG 199 Query: 181 KQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVV 240 KQD +FAGG E+L W ++ FDAMGA+S+KYNDTP ASR YD +RDGFVIAGG G++V+ Sbjct: 200 KQDRMFAGGCEDLDWTLSVLFDAMGAMSSKYNDTPSTASRAYDKNRDGFVIAGGAGVLVL 259 Query: 241 EELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDTPIDYLNSHGT 300 E+LE ALARGA IY EIVGYGATSDG DMVAPSGEGA+RCMKMA+ V + IDY+N H T Sbjct: 260 EDLETALARGAKIYGEIVGYGATSDGYDMVAPSGEGAIRCMKMALSTVTSKIDYINPHAT 319 Query: 301 STPVGDVKELAAIREVF--GDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPS 358 STP GD E+ AIR++F GD P I+ATK++TGHSLGA GVQEAIYSLLM+++ FI S Sbjct: 320 STPAGDAPEIEAIRQIFGAGDVCPPIAATKSLTGHSLGATGVQEAIYSLLMMQNNFICES 379 Query: 359 INIEELDEQAAGLNIVTETTDR-ELTTVMSNSFGFGGTNATLVMRKLK 405 +IEELD A + IV + D +L TV+SNSFGFGGTNATLV ++ + Sbjct: 380 AHIEELDPAFADMPIVRKRIDNVQLNTVLSNSFGFGGTNATLVFQRYQ 427 >3HO9-A nrPDB Length = 427 Score = 486 bits (1252), Expect = e-138, Method: Composition-based stats. Identities = 150/413 (36%), Positives = 219/413 (53%), Gaps = 13/413 (3%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK-LDTTGLI 60 +R V+TGLG++S +GN + +L G+SGI+ S + G VK + +I Sbjct: 18 RRVVVTGLGMLSPVGNTVESTWKALLAGQSGISLIDHFDTSAYATKFAGLVKDFNCEDII 77 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM 120 RK R M Y ++ QA+ D+GL I GG + M Sbjct: 78 SRKEQRKMDAFIQYGIVAGVQAMQDSGLEITEENATRIGAAIGSGIGGLGLIEENHTSLM 137 Query: 121 RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG 180 G G + + P+ V + + V+ L + + G + SI++A + H IG+A I G Sbjct: 138 NG--GPRKISPFFVPSTIVNMVAGHLTIMYGLRGPSISIATAATSGVHNIGHAARIIAYG 195 Query: 181 KQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVV 239 D++ AGG E+ + F A ALST+ ND P+ ASR +D RDGFV+ G GM+V Sbjct: 196 DADVMVAGGAEKASTPLGVGGFGAARALSTR-NDNPQAASRPWDKERDGFVLGDGAGMLV 254 Query: 240 VEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVD-----TPIDY 294 +EE EHA RGA IYAE+VG+G +SD M +P GA + MA D + I Y Sbjct: 255 LEEYEHAKKRGAKIYAELVGFGMSSDAYHMTSPPENGAGAALAMANALRDAGIEASQIGY 314 Query: 295 LNSHGTSTPVGDVKELAAIREVFGDKS--PAISATKAMTGHSLGAAGVQEAIYSLLMLEH 352 +N+HGTSTP GD E A++ +FG+ + +S+TK+MTGH LGAAG E+IYS+L L Sbjct: 315 VNAHGTSTPAGDKAEAQAVKTIFGEAASRVLVSSTKSMTGHLLGAAGAVESIYSILALRD 374 Query: 353 GFIAPSINIEELDEQAAGLNIVTETTDRE-LTTVMSNSFGFGGTNATLVMRKL 404 + P+IN++ DE + E + + NSFGFGGTN +L+ +K+ Sbjct: 375 QAVPPTINLDNPDEGCDLDFVPHEARQVSGMEYTLCNSFGFGGTNGSLIFKKI 427 >3KZU-A nrPDB Length = 428 Score = 482 bits (1240), Expect = e-136, Method: Composition-based stats. Identities = 158/420 (37%), Positives = 230/420 (54%), Gaps = 18/420 (4%) Query: 1 MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK------- 53 M+R VITGLG+VS + + +E L G SG E + + + + Sbjct: 9 MRRVVITGLGLVSPLASGVEETWKRLLAGESGARRVTEFEVDDLACQIACRIPVGDGTNG 68 Query: 54 -LDTTGLIDRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRF 112 + +D K R + +YA + +QA+ DAG PE ++ R G++ GSG G Sbjct: 69 TFNPDLHMDPKEQRKVDPFIVYAVGAADQALDDAGWHPENDEDQVRTGVLIGSGIGGIEG 128 Query: 113 QVFGADAMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGN 172 V +R +G + + P+ + + + S ++ K+ G N+S+ +ACAT H IG+ Sbjct: 129 IVEAGYTLRD-KGPRRISPFFIPGRLINLASGHVSIKHKLRGPNHSVVTACATGTHAIGD 187 Query: 173 AVEQIQLGKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVI 231 A I G D++ AGG E ++ F A ALST+ ND P ASR YD RDGFV+ Sbjct: 188 AARLIAFGDADVMVAGGTESPVSRISLAGFAACKALSTERNDDPTAASRPYDEDRDGFVM 247 Query: 232 AGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAP--SGEGAVRCMKMAMHGV- 288 G G+VV+EELEHALARGA IYAE++GYG + D + AP SGEGA RCM A+ Sbjct: 248 GEGAGIVVLEELEHALARGAKIYAEVIGYGMSGDAFHITAPTESGEGAQRCMVAALKRAG 307 Query: 289 --DTPIDYLNSHGTSTPVGDVKELAAIREVFGDKSPAI--SATKAMTGHSLGAAGVQEAI 344 IDY+N+HGTST + D EL A+ V G+ + I S+TK+ GH LGAAG EA+ Sbjct: 308 IVPDEIDYINAHGTST-MADTIELGAVERVVGEAAAKISMSSTKSSIGHLLGAAGAAEAV 366 Query: 345 YSLLMLEHGFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKL 404 +S L + ++N++ Q + + +R++ +SNSFGFGGTNA+LV+R+ Sbjct: 367 FSTLAIRDNIAPATLNLDNPAAQTRIDLVPHKPRERKIDVALSNSFGFGGTNASLVLRRY 426 >1OXH-A nrPDB Length = 430 Score = 476 bits (1224), Expect = e-134, Method: Composition-based stats. Identities = 143/413 (34%), Positives = 217/413 (52%), Gaps = 12/413 (2%) Query: 1 MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNV-KLDTTGL 59 + R V+TG G+ S IGN +E SL G+ GI + S H + Sbjct: 22 LNRVVVTGYGVTSPIGNTPEEFWNSLATGKIGIGGITKFDHSDFDVHNAAEIQDFPFDKY 81 Query: 60 IDRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADA 119 +K + S+YA + ++A+ A L EA N R G+I SG G + ++ Sbjct: 82 FVKKDTNRFDNYSLYALYAAQEAVNHANLDVEAL-NRDRFGVIVASGIGGIK-EIEDQVL 139 Query: 120 MRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQL 179 +G K V P + KA+ + S +A F +GV SI++AC++S IG+A I+ Sbjct: 140 RLHEKGPKRVKPMTLPKALPNMASGNVAMRFGANGVCKSINTACSSSNDAIGDAFRSIKF 199 Query: 180 GKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMV 238 G QD++ GG E A F A+ ALST + P +AS +D R+GFV+ G GM+ Sbjct: 200 GFQDVMLVGGTEASITPFAIAGFQALTALSTT--EDPTRASIPFDKDRNGFVMGEGSGML 257 Query: 239 VVEELEHALARGAHIYAEIVGYGATSDGADMVA--PSGEGAVRCMKMAMHGV---DTPID 293 V+E LEHA RGA I AE+VGYG T D M + P G+GA++ +K+A+ + Sbjct: 258 VLESLEHAEKRGATILAEVVGYGNTCDAYHMTSPHPEGQGAIKAIKLALEEAEISPEQVA 317 Query: 294 YLNSHGTSTPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHG 353 Y+N+HGTSTP + E AI V G + +S+TK+ TGH LGAAG EAI ++ + H Sbjct: 318 YVNAHGTSTPANEKGESGAIVAVLGKE-VPVSSTKSFTGHLLGAAGAVEAIVTIEAMRHN 376 Query: 354 FIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLKD 406 F+ + E+ + + + ++E+ +SN+FGFGG NA L ++ ++ Sbjct: 377 FVPMTAGTSEVSDYIEANVVYGQGLEKEIPYAISNTFGFGGHNAVLAFKRWEN 429 >3E60-A nrPDB Length = 424 Score = 473 bits (1217), Expect = e-134, Method: Composition-based stats. Identities = 158/422 (37%), Positives = 237/422 (56%), Gaps = 18/422 (4%) Query: 1 MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK------- 53 M+R VITGLG+VS + + + L EG+SG+ E S + + + Sbjct: 5 MRRVVITGLGLVSPLAGDVEYSWKRLLEGKSGVRRITEFDVSDLSCQIAARIPVGDGTNG 64 Query: 54 -LDTTGLIDRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRF 112 + ++ K R + +YA + +QA+ADA P++ ++ G++ GSG G Sbjct: 65 TYNADLHMESKEQRKVDAFIVYAIAAADQALADAEWFPKSDEDQICTGVLIGSGIGGIEG 124 Query: 113 QVFGADAMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGN 172 V +R +G + + P+ + + + S ++ + + G N+S+ +AC+T AH IG+ Sbjct: 125 IVEAGYTLRD-KGPRRISPFFIPGRLINLASGYVSIKYGLRGPNHSVVTACSTGAHAIGD 183 Query: 173 AVEQIQLGKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVI 231 A I LG D++ AGG E ++ F A ALST ND PE+ASR YD RDGFV+ Sbjct: 184 AARLIALGDADVMLAGGTESPINRISLAGFSACRALSTCRNDDPERASRPYDVDRDGFVM 243 Query: 232 AGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAP--SGEGAVRCMKMAMHGVD 289 G +VV+EELEHA RGA IYAEI+GYG + D + AP SGEGA R M A+ Sbjct: 244 GEGAAIVVLEELEHAKKRGARIYAEIIGYGLSGDAYHITAPSESGEGAQRSMMAALKRAQ 303 Query: 290 ---TPIDYLNSHGTSTPVGDVKELAAIREVFGDKSPAI--SATKAMTGHSLGAAGVQEAI 344 + +DY+N+HGTST + DV ELAA+ V G +P + S+TK+ GH LGAAG EAI Sbjct: 304 VNVSELDYINAHGTST-MADVIELAAVERVLGYYAPQVSMSSTKSSIGHLLGAAGAAEAI 362 Query: 345 YSLLMLEHGFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKL 404 + +L + ++N+E + + + +R++ TV+SNSFGFGGTNA+LVMR+ Sbjct: 363 FCVLAIRDNIAPATLNLENPSIETKIDLVPHKPRERKIDTVLSNSFGFGGTNASLVMRRF 422 Query: 405 KD 406 + Sbjct: 423 SE 424 >2IX4-A nrPDB Length = 431 Score = 468 bits (1205), Expect = e-132, Method: Composition-based stats. Identities = 156/434 (35%), Positives = 224/434 (51%), Gaps = 34/434 (7%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLID 61 +R V+TGLG+V+ +G + L +G GI L D M+S KL T + Sbjct: 1 RRVVVTGLGMVTPLGRGVETTWRRLIDGECGIRGLT-LDDLKMKS-FDEETKLYTFDQLS 58 Query: 62 RKVVRFMSD--------------------ASIYAFLSMEQAIADAGLSPEAYQNNPRVGL 101 KV F+ YA + ++A+ DA P + R G+ Sbjct: 59 SKVAAFVPYGSNPGEFDEALWLNSKAVANFIGYAVCAADEALRDAEWLPTEEEEKERTGV 118 Query: 102 IAGSGGGSPRFQVFGADAMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISS 161 G G GS V A + + L+ + P+ + K + + S ++ + G N++ + Sbjct: 119 SIGGGIGSICDIVEAAQLI-CEKRLRRLSPFFIPKILVNMASGHVSMKYGFQGPNHAAVT 177 Query: 162 ACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASR 220 ACAT AH IG+A IQ G D++ AGG E ++ F ALSTK+N +P++ASR Sbjct: 178 ACATGAHSIGDATRMIQFGDADVMVAGGTESSIDALSVAGFSRSRALSTKFNSSPQEASR 237 Query: 221 TYDAHRDGFVIAGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAPS--GEGAV 278 +D RDGFVI G G++V+EE EHA RGA IYAE+ GYG + D + P G+GAV Sbjct: 238 PFDCDRDGFVIGEGSGVIVLEEYEHAKRRGAKIYAELCGYGMSGDAHHITQPPEDGKGAV 297 Query: 279 RCMKMAMHG---VDTPIDYLNSHGTSTPVGDVKELAAIREVFGDKSP----AISATKAMT 331 M A+ IDY+N+H TSTP+GD E AI+ VF + + A S+TK T Sbjct: 298 LAMTRALRQSGLCPNQIDYVNAHATSTPIGDAVEARAIKTVFSEHATSGTLAFSSTKGAT 357 Query: 332 GHSLGAAGVQEAIYSLLMLEHGFIAPSINIEELDEQAAGLNIVTETTDREL-TTVMSNSF 390 GH LGAAG EAI+S+L + HG ++N++ D + T+ + L T MSNSF Sbjct: 358 GHLLGAAGAVEAIFSILAIHHGVAPMTLNVKNPDPIFDKRFMPLTTSKKMLVRTAMSNSF 417 Query: 391 GFGGTNATLVMRKL 404 GFGGTNA+L+ + Sbjct: 418 GFGGTNASLLFASI 431 >2IWZ-A nrPDB Length = 438 Score = 467 bits (1202), Expect = e-132, Method: Composition-based stats. Identities = 136/419 (32%), Positives = 218/419 (52%), Gaps = 23/419 (5%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNV-------KL 54 +R VITG+G+V+ +G V L G SGI + + V V + Sbjct: 21 RRVVITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGEEYKSIPCSVAAYVPRGSDEGQF 80 Query: 55 DTTGLIDRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQV 114 + + + ++ MS +I A + E A+ D+G P++ + G+ G G +V Sbjct: 81 NEQNFVSKSDIKSMSSPTIMAIGAAELAMKDSGWHPQSEADQVATGVAIGMG--MIPLEV 138 Query: 115 FGADAMR-GPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNA 173 A+ +G V P+ V K + + + ++ +K+ G N+++S+AC T AH +G++ Sbjct: 139 VSETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKGPNHAVSTACTTGAHAVGDS 198 Query: 174 VEQIQLGKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIA 232 I G D++ AGG + ++ F ALST N P+ A R + RDGFV+ Sbjct: 199 FRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALST--NSDPKLACRPFHPKRDGFVMG 256 Query: 233 GGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVA--PSGEGAVRCMKMAMHGV-- 288 G ++V+EE EHA+ R A IYAE++GYG + D + A P GEGA+RCM A+ Sbjct: 257 EGAAVLVLEEYEHAVQRRARIYAEVLGYGLSGDAGHITAPDPEGEGALRCMAAALKDAGV 316 Query: 289 -DTPIDYLNSHGTSTPVGDVKELAAIREVFGDKSP--AISATKAMTGHSLGAAGVQEAIY 345 I Y+N+H TSTP+GD E AI+ +F D + A+S+TK TGH LGAAG EA + Sbjct: 317 QPEEISYINAHATSTPLGDAAENKAIKHLFKDHAYALAVSSTKGATGHLLGAAGAVEAAF 376 Query: 346 SLLMLEHGFIAPSINIEELDEQAAGLNIVTETTDRELT---TVMSNSFGFGGTNATLVM 401 + L + + P++N++ + + + + + + ++NSFGFGGTNATL + Sbjct: 377 TTLACYYQKLPPTLNLDCSEPEFDLNYVPLKAQEWKTEKRFIGLTNSFGFGGTNATLCI 435 >4DDO-A nrPDB Length = 451 Score = 445 bits (1145), Expect = e-125, Method: Composition-based stats. Identities = 153/419 (36%), Positives = 230/419 (54%), Gaps = 18/419 (4%) Query: 3 RAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK--------- 53 R V+TG+GIVS +G ++ V L G SG+ + + + V G V+ Sbjct: 25 RVVVTGIGIVSPLGCGKELVWQRLIGGGSGLRRLGDDIAGELSAKVGGTVQDVAEDPEGG 84 Query: 54 LDTTGLIDRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQ 113 D + K +R M A ++ ++A+A+AG +PEA Q R + SG G Sbjct: 85 FDPERSVPHKELRKMDRFIQMAMVAADEALAEAGWAPEAEQQRERTATVVASGIGGFPGL 144 Query: 114 VFGADAMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNA 173 A + RG++ + P+ + +++ + ++ + G +ACA S IG+A Sbjct: 145 AE-AVRIGETRGVRRLSPFTIPFFLSNLAAGQISIKHRFRGPLGCPVTACAASVQAIGDA 203 Query: 174 VEQIQLGKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIA 232 + I+ G+ D+V AGG E +++ F A ALST +++ P +ASR +D RDGFV+ Sbjct: 204 MRMIRTGEADVVLAGGAEAAFDKVSLGGFAAARALSTGFSEEPVRASRPFDRDRDGFVMG 263 Query: 233 GGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVA--PSGEGAVRCMKMAMHG--- 287 G MVVVE L+HALARGA AEI+GYG T+D M A G GA+R MK+A+ Sbjct: 264 EGAAMVVVESLDHALARGARPIAEIIGYGTTADAYHMTAGPDDGSGAMRAMKLALRMGDV 323 Query: 288 VDTPIDYLNSHGTSTPVGDVKELAAIREVFG-DKSPAISATKAMTGHSLGAAGVQEAIYS 346 +DY+N+H TSTPVGD E+ A++ VFG PAIS+TK+ TGH LGAAG EA +S Sbjct: 324 APEQVDYVNAHATSTPVGDAGEIEALKTVFGVGAGPAISSTKSATGHLLGAAGAIEAAFS 383 Query: 347 LLMLEHGFIAPSINIEELDEQAAGLNIVTETTDR-ELTTVMSNSFGFGGTNATLVMRKL 404 +L L G + ++N+E D A GL+++ + +SN FGFGG NA+++ R+ Sbjct: 384 ILALRDGVLPGTLNLEHPDPAADGLDLIGPAARHVPVEIALSNGFGFGGVNASVLFRRY 442 >2GP6-A nrPDB Length = 434 Score = 420 bits (1079), Expect = e-118, Method: Composition-based stats. Identities = 132/410 (32%), Positives = 200/410 (48%), Gaps = 14/410 (3%) Query: 4 AVITGLGIVSSIGNNQQEVLASLREGRSGITFSQE--LKDSGMRSHVWGNVKLDTTGLID 61 V+TG+ + +++ + + L + +SGI + +++ + + G++ + + Sbjct: 30 VVVTGIAMTTALATDAETTWKLLLDRQSGIRTLDDPFVEEFDLPVRIGGHLLEEFDHQLT 89 Query: 62 RKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAMR 121 R +R M + + + +AG SPE N R+ + G+G GS VF D MR Sbjct: 90 RIELRRMGYLQRMSTVLSRRLWENAG-SPEVDTN--RLMVSIGTGLGSAEELVFSYDDMR 146 Query: 122 GPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGK 181 RG+KAV P V K M +G +A + + SACA+ A I A +QI LG+ Sbjct: 147 A-RGMKAVSPLTVQKYMPNGAAAAVGLERHAKAGVMTPVSACASGAEAIARAWQQIVLGE 205 Query: 182 QDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVV 240 D GG E + F M + + ND P A R +D RDGFV GG ++++ Sbjct: 206 ADAAICGGVETRIEAVPIAGFAQMRIVMSTNNDDPAGACRPFDRDRDGFVFGEGGALLLI 265 Query: 241 EELEHALARGAHIYAEIVGYGATSDGADMVAPS------GEGAVRCMKMAMHGVDTPIDY 294 E EHA ARGA+I A I+G TSDG MVAP G R +++A ID+ Sbjct: 266 ETEEHAKARGANILARIMGASITSDGFHMVAPDPNGERAGHAITRAIQLAG-LAPGDIDH 324 Query: 295 LNSHGTSTPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGF 354 +N+H T T VGD+ E AI G PA+ A K+ GHS+GA G E+I ++L L Sbjct: 325 VNAHATGTQVGDLAEGRAINNALGGNRPAVYAPKSALGHSVGAVGAVESILTVLALRDQV 384 Query: 355 IAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKL 404 I P++N+ LD + + E ++NSFGFGG N + + Sbjct: 385 IPPTLNLVNLDPEIDLDVVAGEPRPGNYRYAINNSFGFGGHNVAIAFGRY 434 >1TQY-A nrPDB Length = 424 Score = 415 bits (1066), Expect = e-116, Method: Composition-based stats. Identities = 133/416 (31%), Positives = 201/416 (48%), Gaps = 18/416 (4%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDT--TGL 59 +R VITG+G+ + GN ++ L GR+ S RS V D G Sbjct: 3 RRVVITGVGVRAPGGNGTRQFWELLTSGRTATRRISFFDPSPYRSQVAAEADFDPVAEGF 62 Query: 60 IDRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSP----RFQVF 115 R++ R M AS +A +A A +GL P+ + RVG+ GS + R + Sbjct: 63 GPRELDR-MDRASQFAVACAREAFAASGLDPDTL-DPARVGVSLGSAVAAATSLEREYLL 120 Query: 116 GADAMRGPRGLKA-VGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAV 174 +D+ R A + ++ + S + A +A G +S+ C + +GNAV Sbjct: 121 LSDSGRDWEVDAAWLSRHMFDYLVPSVMPAEVAWAVGAEGPVTMVSTGCTSGLDSVGNAV 180 Query: 175 EQIQLGKQDIVFAGGGEELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAG 233 I+ G D++FAG + + FDA+ A +T ND PE ASR +D RDGFV+A Sbjct: 181 RAIEEGSADVMFAGAADTPITPIVVACFDAIRA-TTARNDDPEHASRPFDGTRDGFVLAE 239 Query: 234 GGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEG-----AVRCMKMAMHGV 288 G M V+E+ + ALARGA I+AEI GY + M +G +R Sbjct: 240 GAAMFVLEDYDSALARGARIHAEISGYATRCNAYHMTGLKADGREMAETIRVALDESRTD 299 Query: 289 DTPIDYLNSHGTSTPVGDVKELAAIREVFGDKS--PAISATKAMTGHSLGAAGVQEAIYS 346 T IDY+N+HG+ T D E AA + G+ + +S+ K+M GHSLGA G E Sbjct: 300 ATDIDYINAHGSGTRQNDRHETAAYKRALGEHARRTPVSSIKSMVGHSLGAIGSLEIAAC 359 Query: 347 LLMLEHGFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMR 402 +L LEHG + P+ N+ D + + E +R+L +V++ GFGG + +V+R Sbjct: 360 VLALEHGVVPPTANLRTSDPECDLDYVPLEARERKLRSVLTVGSGFGGFQSAMVLR 415 >5W2O-A nrPDB Length = 439 Score = 409 bits (1052), Expect = e-115, Method: Composition-based stats. Identities = 130/399 (32%), Positives = 191/399 (47%), Gaps = 14/399 (3%) Query: 14 SIGNNQQEVLASLREGRSGITFSQE--LKDSGMRSHVWGNVKLDTTGLIDRKVVRFMSDA 71 SI + + L G SGI ++ + + + G++K + R +R MS Sbjct: 47 SISPDIESTWKGLLAGESGIHALEDEFVTKWDLAVKIGGHLKDPVDSHMGRLDMRRMSYV 106 Query: 72 SIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAMRGPRGLKAVGP 131 L Q AG SPE + R ++ G+G G V D M G + V P Sbjct: 107 QRMGKLLGGQLWESAG-SPEVDPD--RFAVVVGTGLGGAERIVESYDLMNAG-GPRKVSP 162 Query: 132 YVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGE 191 V M +G +A + + SAC++ + I +A QI +G D+ GG E Sbjct: 163 LAVQMIMPNGAAAVIGLQLGARAGVMTPVSACSSGSEAIAHAWRQIVMGDADVAVCGGVE 222 Query: 192 ELCWEMACE-FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVVEELEHALARG 250 + F M A+ST+ ND PE+ASR +D RDGFV G ++++E EHA ARG Sbjct: 223 GPIEALPIAAFSMMRAMSTR-NDEPERASRPFDKDRDGFVFGEAGALMLIETEEHAKARG 281 Query: 251 AHIYAEIVGYGATSDGADMVAPSGEG--AVRCMKMAMHGV---DTPIDYLNSHGTSTPVG 305 A A ++G G TSD MVAP+ +G A R M ++ ID++N+HGT+TP+G Sbjct: 282 AKPLARLLGAGITSDAFHMVAPAADGVRAGRAMTRSLELAGLSPADIDHVNAHGTATPIG 341 Query: 306 DVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSINIEELD 365 D E AI V G A+ A K+ GHS+GA G E++ ++L L G I P++N E D Sbjct: 342 DAAEANAI-RVAGCDQAAVYAPKSALGHSIGAVGALESVLTVLTLRDGVIPPTLNYETPD 400 Query: 366 EQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKL 404 + + E + ++NSFGFGG N L + Sbjct: 401 PEIDLDVVAGEPRYGDYRYAVNNSFGFGGHNVALAFGRY 439 >1TQY-B nrPDB Length = 415 Score = 353 bits (907), Expect = 6e-98, Method: Composition-based stats. Identities = 91/412 (22%), Positives = 172/412 (41%), Gaps = 16/412 (3%) Query: 2 KRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVK-LDTTGLI 60 K +ITG+G+V+ G +++ +GR G+ S + + G + I Sbjct: 9 KSVLITGVGVVAPNGLGLAPYWSAVLDGRHGLGPVTRFDVSRYPATLAGQIDDFHAPDHI 68 Query: 61 DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRF--QVFGAD 118 +++ ++ A + + A+ DA PE+ + +G++ + G F + F Sbjct: 69 PGRLLPQTDPSTRLALTAADWALQDAKADPESLTDYD-MGVVTANACGGFDFTHREFRKL 127 Query: 119 AMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQ 178 GP+ + + A+ + ++ + G + ++ + A +G+A I+ Sbjct: 128 WSEGPKSVSVYESFAWFYAVNT---GQISIRHGMRGPSSALVAEQAGGLDALGHARRTIR 184 Query: 179 LGKQDIVFAGGGEEL-CWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGM 237 G +V G L W + A G +ST P++A +D G+V GG + Sbjct: 185 RGTPLVVSGGVDSALDPWGWVSQI-ASGRISTAT--DPDRAYLPFDERAAGYVPGEGGAI 241 Query: 238 VVVEELEHALARGAH-IYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDT---PID 293 +V+E+ A ARG H Y E+ G +T D A G R +++A++ T +D Sbjct: 242 LVLEDSAAAEARGRHDAYGELAGCASTFDPAPGSGRPA-GLERAIRLALNDAGTGPEDVD 300 Query: 294 YLNSHGTSTPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHG 353 + + G P D E AI VFG + ++ K TG G + + +L+ L G Sbjct: 301 VVFADGAGVPELDAAEARAIGRVFGREGVPVTVPKTTTGRLYSGGGPLDVVTALMSLREG 360 Query: 354 FIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLK 405 IAP+ + + + ++ E T + + G G N+ V+R+ Sbjct: 361 VIAPTAGVTSVPREYGIDLVLGEPRSTAPRTALVLARGRWGFNSAAVLRRFA 412 >6QSP-A nrPDB Length = 406 Score = 269 bits (689), Expect = 1e-72, Method: Composition-based stats. Identities = 96/409 (23%), Positives = 173/409 (42%), Gaps = 37/409 (9%) Query: 6 ITGLGIVSSIGNNQQEVLASLREGRS-GITFSQELKDSGMRSHVWGNVKLDTTGLIDRKV 64 I+ +G+++++G+N ++ +L G++ G+ G + G V + + + Sbjct: 19 ISAVGMLNALGDNVDDIAQNLVLGQAPGMYERSGWLQPGKTCCLGG-VDAELPA-MPDML 76 Query: 65 VRFMSDASIYAFLSMEQAIADAGLSPEAYQN-----NPRVGLIAGSGGGSPRFQVFGADA 119 S + ++ Q + P+ + R+ +I G+ Sbjct: 77 SEHNSRNNRLLLAALMQ------IKPQVDEAIARHGRERIAVIMGTSTSGLDEGDQHVSR 130 Query: 120 MRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQL 179 + + Y + S LA I G +++S+AC++S+ I + I++ Sbjct: 131 TVYQQSHGSYHDYHYYQQELGDPSRFLARYLAIEGPAFTLSTACSSSSRAIISGQRLIEM 190 Query: 180 GKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVV 239 G D GG + L FD++ +LS + + R G I +++ Sbjct: 191 GLVDAAIVGGADTLSRMPINGFDSLESLSPTLCE-------PFCQDRQGITIGEASTLLL 243 Query: 240 VEELEHALARGAHIYAEIVGYGATSDGADMVA--PSGEGAVRCMKMAMHGV---DTPIDY 294 + +A ++G G +SD M A P G GA+ + MA+ I Y Sbjct: 244 LTREPQPIA--------LLGVGESSDAWHMSAPHPEGRGAIAAINMALRKAGISPAEIGY 295 Query: 295 LNSHGTSTPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGF 354 +N HGT T + D E I ++FG+ +P S+TK +TGH+LGAAG EA L+L Sbjct: 296 INLHGTGTKLNDQMESIVINQIFGENTPC-SSTKYLTGHTLGAAGACEAGLCWLLLTRHL 354 Query: 355 IAPSINIEE--LDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVM 401 P+ + +D ++T++ E VMSNSF FGG N +L++ Sbjct: 355 PLPAQDFTRSGIDIALPACGLLTQSQPLEKPIVMSNSFAFGGNNTSLIL 403 >5ENY-A nrPDB Length = 764 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 100/441 (22%), Positives = 160/441 (36%), Gaps = 59/441 (13%) Query: 4 AVITGLGIVSSIGNNQQEVLASLREGRSGIT--FSQELKDSGMR-----------SHVWG 50 I G+ N +E +L R+ I + G Sbjct: 178 IAIVGMSGRYPGARNVREYWDNLVHARNAIRDIPTSRWDVDKYYDPVLNKKGKVYCKSMG 237 Query: 51 NVKLDTTGL------IDRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAG 104 + D I M +A DAG + N + G+ G Sbjct: 238 MLD-DIEHFDPLFFNIPPSEAELMDPQHRIFLQEGYKAFEDAGYNARTL-NEKKCGVYLG 295 Query: 105 SGGGSPRFQVFGADAMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACA 164 +G R R + + +A + + G I +AC+ Sbjct: 296 -----IMSNEYGVMLNRQSRANATGNSFAI-------AAARIPYFLNLKGPAIPIDTACS 343 Query: 165 TSAHCIGNAVEQIQLGKQDIVFAGG-GEELCWEMACEFDAMGALSTKYNDTPEKASRTYD 223 +S A + + + D+ GG L E G LS P+ + +D Sbjct: 344 SSLVGTHLARQALINKEIDMALVGGVSLYLTPESYMSMCEAGMLS------PDGQCKAFD 397 Query: 224 AHRDGFVIAGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGAD--MVAPSGEGAVRCM 281 +GFV G G +V++ L+ A A HIY I+G G DG + APS + + Sbjct: 398 NGANGFVPGEGAGALVLKRLKDAEADRDHIYGIIIGSGINQDGKTNGITAPSAKSQMDLE 457 Query: 282 K--MAMHGVDTP-IDYLNSHGTSTPVGDVKELAAIREVFGDKS-----PAISATKAMTGH 333 + +G+ I Y+ HGT T GD EL A+ VF +K+ AI + K+ GH Sbjct: 458 RDIYETYGIHPESISYVEMHGTGTKQGDPIELEALSTVFQEKTDKKQFCAIGSVKSNIGH 517 Query: 334 SLGAAGVQEAIYSLLMLEHGFIAPSINIEEL----DEQAAGLNIVT-----ETTDRELTT 384 + AAGV LL + H + P++N + + + L + T ET D + Sbjct: 518 TSAAAGVAGVQKVLLCMNHKTLVPTLNFTTPNEHFEFEHSPLYVNTELKPWETADGKPRR 577 Query: 385 VMSNSFGFGGTNATLVMRKLK 405 +SFG+ GTNA +V+ + + Sbjct: 578 ACVSSFGYSGTNAHIVIEEYQ 598 >4CW4-A nrPDB Length = 639 Score = 247 bits (630), Expect = 8e-66, Method: Composition-based stats. Identities = 93/399 (23%), Positives = 156/399 (39%), Gaps = 40/399 (10%) Query: 38 ELKDSGMR---SHVWGNVKLDTTGLIDRKV--VRFMSDASIYAFLSMEQAIADAGLS--- 89 E K R G + TG ++ RF + ++ AI G+ Sbjct: 156 EFKVDSYRALTVKSAGQL---PTGFEPGELYNSRFHPRGLQMSVVAATDAIRSTGIDWKT 212 Query: 90 PEAYQNNPRVGLIAGSGGGSPRFQVFGADAMRGPRGLKAVGPYVVTKAMASGVSACLATP 149 + + +GS FG +G V + S + + Sbjct: 213 IVDNVQPDEIAVFSGSIMSQLDDNGFGGLMQSRLKGH-RVSAKQLPLGFNSMPTDFINAY 271 Query: 150 -FKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMAC-EFDAMGAL 207 G+ SI+ ACAT + + ++ I G+ +V G E + AMGAL Sbjct: 272 VLGSVGMTGSITGACATFLYNLQKGIDVITSGQARVVIVGNSEAPILPECIEGYSAMGAL 331 Query: 208 STK--------YNDTP-EKASRTYDAHRDGFVIAGGGGMVVVEELEHALARGAHIYAEIV 258 +T+ +D +ASR + GF +A VV+ + E AL GA I+ + Sbjct: 332 ATEEGLRLIEGRDDVDFRRASRPF-GENCGFTLAESSQYVVLMDDELALRLGADIHGAVT 390 Query: 259 GYGATSDGAD-MVAPSGEGAVRCMKMAMH------GVDT--PIDYLNSHGTSTPVGDVKE 309 +DG ++ G G + A+ G+DT ++++HG+STP V E Sbjct: 391 DVFINADGFKKSISAPGPGNYLTVAKAVASAVQIVGLDTVRHASFVHAHGSSTPANRVTE 450 Query: 310 ---LAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAP--SIN--IE 362 L + FG ++A KA GHSL A + I +L ++G + +I+ + Sbjct: 451 SEILDRVASAFGIDGWPVTAVKAYVGHSLATASADQLISALGTFKYGILPGIKTIDKVAD 510 Query: 363 ELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVM 401 ++ +Q ++ D+ L NS GFGG NA+ V+ Sbjct: 511 DVHQQRLSISNRDMRQDKPLEVCFINSKGFGGNNASGVV 549 >4OQJ-A nrPDB Length = 845 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 103/451 (22%), Positives = 161/451 (35%), Gaps = 75/451 (16%) Query: 4 AVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSH-------------VWG 50 + GL L EGR D +R+ G Sbjct: 23 IAVIGLACRFPGAATPDTFWKVLSEGR---ETLTHFSDEELRAAGVAEPLLADDRYVKAG 79 Query: 51 NVKLDTTGL------IDRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAG 104 V +D I R + +A+ AG P+ + R+G+ AG Sbjct: 80 QVLVDADKFDAGLFGITRDEAELIDPQQRQFLECAYEALERAGYDPQ--RGEQRIGVYAG 137 Query: 105 SGGGSPRFQVFGADAMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIH----GVNYSIS 160 G + + + M + +AT G + S + Sbjct: 138 VG-------LNTYLLHNLGERYRTASSVDRYRMMITNDKDFVATRTAYKLNLCGPSVSTN 190 Query: 161 SACATSAHCIGNAVEQIQLGKQDIVFAGGG-------EELCWEMACEFDAMGALSTKYND 213 +AC+TS + A + G + AG E F Sbjct: 191 TACSTSLVAVHLACLSLLSGDCTMALAGAAHIQADQGEGYLHHEGMIFS----------- 239 Query: 214 TPEKASRTYDAHRDGFVIAGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGAD---MV 270 P+ R +DA G VI G G VV++ L ALA G ++A I G +DG+D Sbjct: 240 -PDGHCRAFDAKAQGTVIGNGVGAVVLKRLSDALADGDTVHAVIKGTAVNNDGSDKTGYT 298 Query: 271 APSGEGAVRCMKMAMHGVDT---PIDYLNSHGTSTPVGDVKELAAIREVFGDKS------ 321 APS +G + A D + Y+ +HGT+TP+GD E+AA+ + F + Sbjct: 299 APSVQGQAAVVAEAQEIADVGPETVSYVEAHGTATPLGDPIEVAALNQAFNREGAALAPG 358 Query: 322 -PAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSINIEELDEQAA----GLNIVTE 376 A+ + K GH AAG+ I ++LML H + PS+ E + + + TE Sbjct: 359 SCALGSVKTNVGHLDTAAGMAGLIKTILMLRHRTLVPSLCFEAPNPEIDFAAGPFYVGTE 418 Query: 377 TTDRELTTVMS----NSFGFGGTNATLVMRK 403 T + +SFG GGTNA +++ + Sbjct: 419 TKEWPAGPTPRRAGVSSFGIGGTNAHVIVEE 449 >2EBD-A nrPDB Length = 309 Score = 45.8 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 35/199 (17%), Positives = 57/199 (28%), Gaps = 57/199 (28%) Query: 60 IDRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADA 119 I + + + A + ++A+ +A LSPE + A Sbjct: 39 IKERRIAKEETITYMATQAAKEALREANLSPEELD------------------LIILATL 80 Query: 120 MRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGV-NYSISSACATSAHCIGNAVEQIQ 178 R + + K GV + IS+AC+ + + A I+ Sbjct: 81 TPQKRFPS--------------TACLVQAQLKAKGVYAFDISAACSGFIYALDIADSFIK 126 Query: 179 LGKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMV 238 GK V G E+ LS + + G G V Sbjct: 127 SGKAKNVLVIGAEK--------------LSEAVDWEDRSTCVLF---------GDGAGAV 163 Query: 239 VVEELEH-ALARGAHIYAE 256 VV E + +YAE Sbjct: 164 VVTRSEDKSDILATRMYAE 182 >4DD5-A nrPDB Length = 396 Score = 45.4 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 20/133 (15%), Positives = 40/133 (30%), Gaps = 30/133 (22%) Query: 71 ASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAMRGPRGLKAVG 130 A + ++AI A ++P+ + G++ G + Q+ + + Sbjct: 31 AVELGVTAAKEAIKRANITPDMIDESLLGGVLTAGLGQNIARQIALGAGIPVEK------ 84 Query: 131 PYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGG 190 +I+ C + + A + I LG DI+ GG Sbjct: 85 ------------------------PAMTINIVCGSGLRSVSMASQLIALGDADIMLVGGA 120 Query: 191 EELCWEMACEFDA 203 E + A Sbjct: 121 ENMSMSPYLVPSA 133 Score = 36.9 bits (84), Expect = 0.018, Method: Composition-based stats. Identities = 30/129 (23%), Positives = 43/129 (33%), Gaps = 22/129 (17%) Query: 225 HRDGFV-------IAGGGGMVVVEELEHALARGAHIYAEIVGYGATS-DGADMVAPSGEG 276 +DG V I G M+VV E A G A IV YG D M G G Sbjct: 241 KKDGTVTAGNASGINDGAAMLVVMAKEKAEELGIEPLATIVSYGTAGVDPKIM----GYG 296 Query: 277 AVRCMKMAMHGVD---TPIDYLNSHGTSTPVGDVKELAAIREVFGDKSPAISATKA--MT 331 V K A+ + ID + ++ + A+ ++ Sbjct: 297 PVPATKKALEAANMTIEDIDLVEAN-----EAFAAQSVAVIRDLNIDMNKVNVNGGAIAI 351 Query: 332 GHSLGAAGV 340 GH +G +G Sbjct: 352 GHPIGCSGA 360 >4N44-A nrPDB Length = 400 Score = 43.8 bits (102), Expect = 1e-04, Method: Composition-based stats. Identities = 23/131 (17%), Positives = 43/131 (32%), Gaps = 30/131 (22%) Query: 70 DASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAMRGPRGLKAV 129 A ++++A+ AG+ PE N +G + +G G + Sbjct: 25 PAVDLGATAIKEAVKKAGIKPEDV-NEVILGNVLQAGLG---------------QNPAR- 67 Query: 130 GPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGG 189 S P +I +I+ C + + A + I+ G D++ AGG Sbjct: 68 -----------QASFKAGLPVEI--PAMTINKVCGSGLRTVSLAAQIIKAGDADVIIAGG 114 Query: 190 GEELCWEMACE 200 E + Sbjct: 115 MENMSRAPYLA 125 Score = 36.9 bits (84), Expect = 0.015, Method: Composition-based stats. Identities = 30/135 (22%), Positives = 50/135 (37%), Gaps = 12/135 (8%) Query: 225 HRDGFVIAGGG-------GMVVVEELEHALARGAHIYAEIVGYGATS-DGADMVAPSGEG 276 +DG V AG ++V+ E A G A+IV YG+ D A M G G Sbjct: 236 KKDGTVTAGNASGLNDCAAVLVIMSAEKAKELGVKPLAKIVSYGSAGVDPAIM----GYG 291 Query: 277 AVRCMKMAMHGVDTPIDYLNSHGTSTPVGDVKELAAIREVFGDKSPAISATKAMTGHSLG 336 K A+ +D L+ ++ A F ++ GH +G Sbjct: 292 PFYATKAAIEKAGWTVDELDLIESNEAFAAQSLAVAKDLKFDMNKVNVNGGAIALGHPIG 351 Query: 337 AAGVQEAIYSLLMLE 351 A+G + + + ++ Sbjct: 352 ASGARILVTLVHAMQ 366 >4NZS-A nrPDB Length = 399 Score = 43.5 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 15/69 (21%), Positives = 26/69 (37%) Query: 135 TKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELC 194 + M G A + I+ +++ C + I +A + I LG D+ GG E + Sbjct: 67 PRDMYLGRVAAVNGGVTINAPALTVNRLCGSGLQAIVSAAQTILLGDTDVAIGGGAESMS 126 Query: 195 WEMACEFDA 203 A Sbjct: 127 RAPYLAPAA 135 >4E1L-A nrPDB Length = 395 Score = 42.3 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 14/60 (23%), Positives = 26/60 (43%), Gaps = 2/60 (3%) Query: 142 VSACLATPFKIHG--VNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMAC 199 V+ +A I +Y+++ C + + A + I G+ D+V AGG E + Sbjct: 68 VARQIAINAGIPNSVPSYTVNKLCGSGLKSVQLAAQSITSGENDVVIAGGTENMSQAPYI 127 Score = 41.1 bits (95), Expect = 9e-04, Method: Composition-based stats. Identities = 25/130 (19%), Positives = 45/130 (34%), Gaps = 24/130 (18%) Query: 225 HRDGFV-------IAGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAPS--GE 275 +DG V I G M+++ + A G A+I Y + V P G Sbjct: 240 KKDGTVTAGNASGINDGAAMLILMSQQKADELGIRPLAKIKSYASAG-----VEPEVMGT 294 Query: 276 GAVRCMKMAMHGVD---TPIDYLNSHGTSTPVGDVKELAAIREVFGDKSPAISATKAMT- 331 G + + A+ ID + ++ + A++ S ++ Sbjct: 295 GPIPATRKALKKAGLSINDIDLIEAN-----EAFAAQALAVKNELQIDSSKLNVNGGAIA 349 Query: 332 -GHSLGAAGV 340 GH +GA+G Sbjct: 350 LGHPIGASGA 359 >5ZQZ-B nrPDB Length = 474 Score = 41.5 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 16/69 (23%), Positives = 27/69 (39%) Query: 144 ACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACEFDA 203 A L F ++++ AC ++ + V I G+ D++ AGG E + Sbjct: 119 AALGAGFSDKTPAHTVTMACISANQAMTTGVGLIASGQCDVIVAGGVELMSDVPIRHSRK 178 Query: 204 MGALSTKYN 212 M L N Sbjct: 179 MRKLMLDLN 187 >4WYS-A nrPDB Length = 405 Score = 40.4 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 32/148 (21%), Positives = 52/148 (35%), Gaps = 23/148 (15%) Query: 217 KASRT-YDAHRDGFV-------IAGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGAD 268 A R +D G V I G +V+ E ALA G A I Y + Sbjct: 233 GALRPAFDK--AGTVTAGNASGINDGAAALVIMEESAALAAGLTPLARIKSYASGGVP-- 288 Query: 269 MVAPSGEGAVRCMKMAMHGVD---TPIDYLNSHGTSTPVGDVKELAAIREVFGDKSPAIS 325 A G G V + A+ ID + ++ + A+ + G S ++ Sbjct: 289 -PALMGMGPVPATQKALQLAGLQLADIDLIEAN-----EAFAAQFLAVGKNLGFDSEKVN 342 Query: 326 ATKAMT--GHSLGAAGVQEAIYSLLMLE 351 GH +GA+G + + L ++ Sbjct: 343 VNGGAIALGHPIGASGARILVTLLHAMQ 370 >6ARG-A nrPDB Length = 399 Score = 40.0 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 11/42 (26%), Positives = 18/42 (42%) Query: 156 NYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEM 197 +++ CA+ I + I G D+V AGG E + Sbjct: 86 CTTVNKVCASGLKAIILGAQTIMTGNADVVVAGGTESMSNAP 127 Score = 29.2 bits (64), Expect = 3.3, Method: Composition-based stats. Identities = 18/114 (15%), Positives = 39/114 (34%), Gaps = 11/114 (9%) Query: 231 IAGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDT 290 + G VV+ A+I+G+G D A + + A+ Sbjct: 256 LNDGAAAVVLVSEAKLKELNLKPVAKILGWG---DAAQQPSKFTTAPALAIPKALKHAGV 312 Query: 291 PIDYLNSHGTSTPVGDVKELAAIRE--VFG--DKSPAISATKAMTGHSLGAAGV 340 D +++ + + + A+ + G ++ + GH +GA+G Sbjct: 313 GQDAIDAF----EINEAFSVVALANMKLLGIPEEKVNLHGGAVAIGHPIGASGA 362 >2IBU-A nrPDB Length = 395 Score = 39.6 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 24/130 (18%), Positives = 42/130 (32%), Gaps = 30/130 (23%) Query: 70 DASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAMRGPRGLKAV 129 A+ ++++ AI AG+ P+ +G + G G + Sbjct: 31 PATKLGSIAIQGAIEKAGI-PKEEVKEAYMGNVLQGGEGQAPTR---------------- 73 Query: 130 GPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGG 189 A L I +I+ CA+ I A + + G QD++ AGG Sbjct: 74 -------------QAVLGAGLPISTPCTTINKVCASGMKAIMMASQSLMCGHQDVMVAGG 120 Query: 190 GEELCWEMAC 199 E + Sbjct: 121 MESMSNVPYV 130 >3SS6-A nrPDB Length = 394 Score = 38.8 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 15/42 (35%), Positives = 22/42 (52%) Query: 157 YSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMA 198 Y+I C++ I +A QIQLG ++V AGG E + Sbjct: 85 YTIQRQCSSGMQAIMSAAMQIQLGVSEVVVAGGVEAMSSSPY 126 Score = 38.1 bits (87), Expect = 0.007, Method: Composition-based stats. Identities = 16/60 (26%), Positives = 24/60 (40%), Gaps = 5/60 (8%) Query: 231 IAGGGGMVVVEELEHALARGAHIYAEIVGYGATS-DGADMVAPSGEGAVRCMKMAMHGVD 289 + G ++V+ E A +G A IVGY D M G G ++ + VD Sbjct: 251 LNDGSAVLVLMSEEKAKEKGLQPLARIVGYSVAGVDPKIM----GIGPAPAIRKGLEKVD 306 >2AJ9-A nrPDB Length = 356 Score = 38.8 bits (89), Expect = 0.004, Method: Composition-based stats. Identities = 22/102 (21%), Positives = 36/102 (35%), Gaps = 24/102 (23%) Query: 142 VSACLATPFKIHGV-NYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACE 200 + +A G+ + +S+ CA + +G A + I+ G + G E+L + Sbjct: 121 AAPMVAASLGAKGILGFDLSAGCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDM- 179 Query: 201 FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVVEE 242 YDA F+ A G VVV E Sbjct: 180 ---------------------YDAGNC-FIFADGAAAVVVGE 199 >4EWP-A nrPDB Length = 350 Score = 38.4 bits (88), Expect = 0.006, Method: Composition-based stats. Identities = 33/181 (18%), Positives = 56/181 (30%), Gaps = 26/181 (14%) Query: 105 SGGGSPRFQVFGADAMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIH-GVNYSISSAC 163 G+ R + A V A S +A +A Y +S+AC Sbjct: 65 MAVGAAREALERAGLQGSDLDAVIVSTVTFPHATPS-AAALVAHEIGATPAPAYDVSAAC 123 Query: 164 ATSAHCIGNAVEQIQLGKQDIVFAGGGEEL-----CWEMACEF---DAMGALSTKYNDTP 215 A + + A ++ G V G E L + + F D GA+ +D P Sbjct: 124 AGYCYGVAQADALVRSGTARHVLVVGVERLSDVVDPTDRSISFLLGDGAGAVIVAASDEP 183 Query: 216 EKASRTY--DAHRDGFVIAGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAPS 273 + + D R + + + + +EHA T D + + Sbjct: 184 GISPSVWGSDGERWSTISMTHSQLELRDAVEHAR--------------TTGDASAITGAE 229 Query: 274 G 274 G Sbjct: 230 G 230 >6ESQ-A nrPDB Length = 392 Score = 37.3 bits (85), Expect = 0.012, Method: Composition-based stats. Identities = 15/60 (25%), Positives = 29/60 (48%), Gaps = 4/60 (6%) Query: 155 VNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDT 214 + +ACA+ + + +AV + G D+V AGG E++ DA A+++ + Sbjct: 77 PCTRVEAACASGSLALRSAVLSVASGHHDVVLAGGVEKMTDVE----DATAAIASASDQE 132 >3GOA-A nrPDB Length = 387 Score = 37.3 bits (85), Expect = 0.014, Method: Composition-based stats. Identities = 8/37 (21%), Positives = 15/37 (40%) Query: 155 VNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGE 191 +++ C +S + +A I G + GG E Sbjct: 83 PAVTVNRLCGSSMQALHDAARMIMTGDAQVCLVGGVE 119 >4C2K-A nrPDB Length = 417 Score = 36.9 bits (84), Expect = 0.015, Method: Composition-based stats. Identities = 11/59 (18%), Positives = 23/59 (38%), Gaps = 2/59 (3%) Query: 143 SACLATPFKI--HGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMAC 199 + + I +I+ C + I N ++I + + ++V GG E + C Sbjct: 90 ARHVGLRVGIPKETPALTINRLCGSGFQSIVNGCQEICVKEAEVVLCGGTESMSQAPYC 148 Score = 34.2 bits (77), Expect = 0.11, Method: Composition-based stats. Identities = 31/137 (22%), Positives = 47/137 (34%), Gaps = 38/137 (27%) Query: 225 HRDGFV-------IAGGGGMVVVEELEHALARGAHIYAEIVGYGAT-SDGADMVAPSGEG 276 +DG V +A G G V++ + A IVGY + D + M G G Sbjct: 260 KKDGTVTAGNASGVADGAGAVIIASEDAVKKHNFTPLARIVGYFVSGCDPSIM----GIG 315 Query: 277 AVRCMKMAMHGVDTPIDYLNSHGTSTPVGDVKELAAIREVFG------DKSPAISATKAM 330 V + A+ G S D+ E + E F ++S + +K Sbjct: 316 PVPAISGALKKA----------GLSLKDMDLVE---VNEAFAPQYLAVERSLDLDISKTN 362 Query: 331 T-------GHSLGAAGV 340 GH LG +G Sbjct: 363 VNGGAIALGHPLGGSGS 379 >3SVK-A nrPDB Length = 407 Score = 36.1 bits (82), Expect = 0.027, Method: Composition-based stats. Identities = 24/93 (25%), Positives = 36/93 (38%), Gaps = 13/93 (13%) Query: 163 CATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTY 222 CA+ + A ++++ G D+V AGG E + MG+ + PE R Sbjct: 96 CASGLEAVNTAAQKVRSGWDDLVLAGGVESMSRVP------MGSDGGAWATDPETNYRI- 148 Query: 223 DAHRDGFVIAGGGGMVVVEELEHALARGAHIYA 255 GFV G G ++ LE YA Sbjct: 149 -----GFVP-QGIGADLIATLEGFSREDVDAYA 175 >4BI9-A nrPDB Length = 454 Score = 35.7 bits (81), Expect = 0.034, Method: Composition-based stats. Identities = 17/80 (21%), Positives = 30/80 (37%), Gaps = 5/80 (6%) Query: 10 GIVSSIGNNQQEVLASLREGRSGITFSQELKD-SGMRSHVWGNVKLDTTGLIDRKVVRFM 68 G +S G Q +L G S I + ++ + + + V G+ K R + Sbjct: 134 GACASGGLAVQSAWEALLAGTSQIALAVGVEVQTTVSARVGGDYLARAAHY---KRQRQL 190 Query: 69 SDASIYAFLSMEQ-AIADAG 87 D + + AI +AG Sbjct: 191 DDFTFPCLFARRMKAIQEAG 210 Score = 30.7 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 10/41 (24%), Positives = 15/41 (36%) Query: 155 VNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCW 195 + ACA+ + +A E + G I A G E Sbjct: 128 PAVRVEGACASGGLAVQSAWEALLAGTSQIALAVGVEVQTT 168 >6BN2-A nrPDB Length = 401 Score = 35.4 bits (80), Expect = 0.041, Method: Composition-based stats. Identities = 10/46 (21%), Positives = 20/46 (43%), Gaps = 4/46 (8%) Query: 150 FKIHGVNYSISSA----CATSAHCIGNAVEQIQLGKQDIVFAGGGE 191 N + ++A CA+ + A + ++ G + + AGG E Sbjct: 79 LGAGLPNTTPTTAVNKVCASGMKAVMMAAQAVKAGDVEAIVAGGME 124 Score = 34.6 bits (78), Expect = 0.087, Method: Composition-based stats. Identities = 23/131 (17%), Positives = 49/131 (37%), Gaps = 17/131 (12%) Query: 230 VIAGGGGMVVVEELEHALARGAHIYAEIVGYGATSDG--ADMVAPSGEGAVRCMKMAMHG 287 + G +V+ E + G A+IV Y + AP + + +A+ Sbjct: 256 TLNDGASALVLMSKEKMESLGLKPLAKIVSYADAAQAPEWFTTAP-----AKALPIALAK 310 Query: 288 VD---TPIDYLNSHGTSTPVGDVKELAAIREVFGDKSPAISATKAMT--GHSLGAAGVQE 342 + ID+ + + VG A ++ G + ++ GH LG++G + Sbjct: 311 ANLTINDIDFFEFNEAFSVVG-----LANNKILGLDAAKVNVNGGAVALGHPLGSSGSRI 365 Query: 343 AIYSLLMLEHG 353 + + +L+ Sbjct: 366 IVTLINVLKQN 376 >4B3J-C nrPDB Length = 403 Score = 35.4 bits (80), Expect = 0.044, Method: Composition-based stats. Identities = 16/53 (30%), Positives = 25/53 (47%), Gaps = 2/53 (3%) Query: 163 CATSAHCIGNAVEQIQLGKQDIVFAGGGEELCW-EMACEFDAMGALSTKYNDT 214 CA+ + A ++++ G D+V AGG E + M + AMG L N Sbjct: 92 CASGLEAVNTAAQKVRSGWDDLVLAGGVESMSRVPMGSDGGAMG-LDPATNYD 143 >5XYJ-B nrPDB Length = 408 Score = 35.4 bits (80), Expect = 0.046, Method: Composition-based stats. Identities = 14/66 (21%), Positives = 26/66 (39%), Gaps = 3/66 (4%) Query: 143 SACLATPFKIHG--VNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACE 200 + +A + V +++ A++ I + I+ G D+V AGG E + Sbjct: 79 ARQVALAAGLSNHIVASTVNKVAASAMKAIILGAQSIKCGNADVVVAGGCESMTNAPYY- 137 Query: 201 FDAMGA 206 A A Sbjct: 138 MPAARA 143 >5BNS-A nrPDB Length = 317 Score = 35.0 bits (79), Expect = 0.059, Method: Composition-based stats. Identities = 16/116 (13%), Positives = 35/116 (30%), Gaps = 24/116 (20%) Query: 142 VSACLATPFKIHG-VNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACE 200 + + + I G + +++ACA + + A + ++ G G + L Sbjct: 90 AACQIQSMLGIKGCPAFDVAAACAGFTYALSVADQYVKSGAVKYALVVGSDVL------- 142 Query: 201 FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVVEELEHALARGAHIYAE 256 + D + G G V+ E H++A+ Sbjct: 143 ---------------ARTCDPTDRGTI-IIFGDGAGAAVLAASEEPGIISTHLHAD 182 >4NHD-A nrPDB Length = 319 Score = 34.6 bits (78), Expect = 0.073, Method: Composition-based stats. Identities = 19/116 (16%), Positives = 40/116 (34%), Gaps = 24/116 (20%) Query: 142 VSACLATPFKIHG-VNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACE 200 + + I G + +++AC+ + + A + ++ G V G + L Sbjct: 93 AACQVQGKLGIKGCPAFDLAAACSGFMYALSIADQHVKSGMCKHVLVIGADAL------- 145 Query: 201 FDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVVEELEHALARGAHIYAE 256 +K D ++++ + G G VVV HI+A+ Sbjct: 146 --------SKTCDPTDRSTI--------ILFGDGAGAVVVGASNEPGILSTHIHAD 185 >5LP7-H nrPDB Length = 393 Score = 34.6 bits (78), Expect = 0.082, Method: Composition-based stats. Identities = 11/68 (16%), Positives = 24/68 (35%), Gaps = 7/68 (10%) Query: 134 VTKAMASGVSACLATPFKIH-------GVNYSISSACATSAHCIGNAVEQIQLGKQDIVF 186 V + S + + + +++ CA+ + + I+ DI+ Sbjct: 52 VMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMIRAQDADILV 111 Query: 187 AGGGEELC 194 AGG E + Sbjct: 112 AGGMESMS 119 Score = 34.2 bits (77), Expect = 0.11, Method: Composition-based stats. Identities = 12/41 (29%), Positives = 17/41 (41%) Query: 233 GGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAPS 273 G G V+ E A G A I+G+ T A +A + Sbjct: 252 DGAGAFVLMSEEKAAELGKRPLATILGFSTTGMPAHELAAA 292 >1WL4-A nrPDB Length = 397 Score = 34.6 bits (78), Expect = 0.087, Method: Composition-based stats. Identities = 33/116 (28%), Positives = 43/116 (37%), Gaps = 17/116 (14%) Query: 231 IAGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAPS--GEGAVRCMKMAMHGV 288 I G VV+ + A RG A IV + V PS G G + +K A+ Sbjct: 254 INDGAAAVVLMKKSEADKRGLTPLARIVSWSQVG-----VEPSIMGIGPIPAIKQAVTKA 308 Query: 289 -----DTPIDYLNSHGTSTPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAG 339 D I +N + VKEL E + AI GH LGA+G Sbjct: 309 GWSLEDVDIFEINEAFAAVSAAIVKELGLNPEKVNIEGGAI-----ALGHPLGASG 359 Score = 33.8 bits (76), Expect = 0.15, Method: Composition-based stats. Identities = 28/137 (20%), Positives = 44/137 (32%), Gaps = 20/137 (14%) Query: 85 DAGLSPEAYQNNPRVGLIAGSGGGSPRFQ--------VFGADAMRGPRGLKAVGPYVVTK 136 +AG P + R I GS G+ V R + V + Sbjct: 2 NAGSDPVVIVSAART--IIGSFNGALAAVPVQDLGSTVIKEVLKRATVAPEDVSEVIFGH 59 Query: 137 AMASG--------VSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAG 188 +A+G S P+ + +S C + + AV+ I +G IV AG Sbjct: 60 VLAAGCGQNPVRQASVGAGIPYSV--PAWSCQMICGSGLKAVCLAVQSIGIGDSSIVVAG 117 Query: 189 GGEELCWEMACEFDAMG 205 G E + + G Sbjct: 118 GMENMSKAPHLAYLRTG 134 >5CBQ-A nrPDB Length = 413 Score = 34.2 bits (77), Expect = 0.10, Method: Composition-based stats. Identities = 10/40 (25%), Positives = 17/40 (42%) Query: 155 VNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELC 194 + C + + A Q++ G D+V AGG E + Sbjct: 88 PGMQVDRRCGSGLQAVIQACLQVRSGDHDLVVAGGAESMS 127 >4YLT-A nrPDB Length = 316 Score = 34.2 bits (77), Expect = 0.11, Method: Composition-based stats. Identities = 28/186 (15%), Positives = 54/186 (29%), Gaps = 60/186 (32%) Query: 74 YAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAMRGPRGLKAVGPYV 133 F + E+A+ AG+ + +GLI + Sbjct: 54 MGFQAAEKALEMAGI------DKDDIGLII---------------------VATTSSSHA 86 Query: 134 VTKAMASGVSACLATPFKIH-GVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEE 192 + + + I ++ +++ACA + + A + ++ G G + Sbjct: 87 FPSS-----ACQVQRMLGIKDAASFDLAAACAGFTYALSVADQYVKSGAVKHAIVIGSDV 141 Query: 193 LCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVI--AGGGGMVVVEELEHALARG 250 L SR D G +I G G VV+ E Sbjct: 142 L-------------------------SRALDPEDRGTIILFGDGAGAVVLGASEQPGIMS 176 Query: 251 AHIYAE 256 H++A+ Sbjct: 177 THLHAD 182 >6HRV-A nrPDB Length = 421 Score = 33.8 bits (76), Expect = 0.14, Method: Composition-based stats. Identities = 18/73 (24%), Positives = 31/73 (42%), Gaps = 12/73 (16%) Query: 144 ACLATPF--KIHG-VNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACE 200 A + G ++++ C+T + + + IQ G D V A G E++ Sbjct: 73 GQRAIYHSLGLSGIPIINVNNNCSTGSTALFMGRQLIQGGLADCVLALGFEKM------- 125 Query: 201 FDAMGALSTKYND 213 G+LS+KY D Sbjct: 126 --ERGSLSSKYMD 136 >1NL7-A nrPDB Length = 392 Score = 33.8 bits (76), Expect = 0.15, Method: Composition-based stats. Identities = 10/38 (26%), Positives = 16/38 (42%) Query: 163 CATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACE 200 C + + ++QI G I+ AGG E + C Sbjct: 89 CGSGLRAVALGMQQIATGDASIIVAGGMESMSMAPHCA 126 Score = 33.4 bits (75), Expect = 0.16, Method: Composition-based stats. Identities = 20/116 (17%), Positives = 37/116 (31%), Gaps = 15/116 (12%) Query: 231 IAGGGGMVVVEELEHALARGAHIYAEIVGYGATS-DGADMVAPSGEGAVRCMKMAMHGVD 289 + G ++ A RG IV + D M G G + + A+ Sbjct: 249 LNDGAAAALLMSEAEASRRGIQPLGRIVSWATVGVDPKVM----GTGPIPASRKALERAG 304 Query: 290 TPI---DYLNSHGTSTPVGDVKELAAIREVFGDKSPAISATKA--MTGHSLGAAGV 340 I D + ++ + A+ + G ++ GH +GA+G Sbjct: 305 WKIGDLDLVEAN-----EAFAAQACAVNKDLGWDPSIVNVNGGAIAIGHPIGASGA 355 >5M3K-C nrPDB Length = 398 Score = 33.4 bits (75), Expect = 0.19, Method: Composition-based stats. Identities = 19/130 (14%), Positives = 35/130 (26%), Gaps = 30/130 (23%) Query: 71 ASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAMRGPRGLKAVG 130 S +A+ DA + P Q + G G + G + Sbjct: 26 FKEMIVESAYKALKDAKMHPREIQ-----AVAYGYHGEGISEYGGLGPTISDALG---IS 77 Query: 131 PYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGG 190 P + ++ C +S+ + + G+ DIV GG Sbjct: 78 P----------------------APTFMSTANCTSSSVSFQMGHQMVASGEYDIVLCGGF 115 Query: 191 EELCWEMACE 200 E++ Sbjct: 116 EKMTDHFNYA 125 >4X0O-A nrPDB Length = 362 Score = 33.4 bits (75), Expect = 0.19, Method: Composition-based stats. Identities = 57/326 (17%), Positives = 92/326 (28%), Gaps = 98/326 (30%) Query: 64 VVRFMS--DASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAMR 121 R +S + S A ++ + AIA AG+S E +I + Sbjct: 43 EQRRISHVNTSDLATVAAQHAIACAGVSVEEIDL-----IIVAT---------------- 81 Query: 122 GPRGLKAVGPYVVTKAMASGVSACLATPFKI-HGVNYSISSACATSAHCIGNAVEQIQLG 180 P + + S + I + +++AC + + A +Q Sbjct: 82 -------CSP---DSLIPNIAS-RVQQNLGIPSAAAFDLNAACTGFLYGLETATRLMQAS 130 Query: 181 KQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVV 240 G E LS + + + G G VV+ Sbjct: 131 HYRHALVIGAE--------------RLSFYLD---------WTKRDTAVLFGDGAGAVVL 167 Query: 241 EELEHAL----------ARGAHIYAEIVGYGATSD---------GADMVAPS-------G 274 + E + A+G I A + +G D D V G Sbjct: 168 SKTEQKVGLQDAQIGCDAQGRDILA-VPKFGTAMDRFDADNGYWAFDFVGKEIFKRAVRG 226 Query: 275 EGAVRCMKMAMHGVDT-PIDYLNSHGTSTPVGDVKELAAIREVFGDKSPAISATKAMTG- 332 GA +A G+ T ID + H + I+ + I+ KA Sbjct: 227 MGAAAQQVLARSGLSTEEIDVVIPH--------QANIRIIQTL--CDLAGIAQDKAFVNI 276 Query: 333 HSLGAAGVQEAIYSL-LMLEHGFIAP 357 H G +L LE G I P Sbjct: 277 HRYGNTSAATVPIALCEALEQGKIKP 302 >4KR4-A nrPDB Length = 341 Score = 33.1 bits (74), Expect = 0.24, Method: Composition-based stats. Identities = 17/76 (22%), Positives = 27/76 (35%), Gaps = 5/76 (6%) Query: 261 GATSDGADMVAPSGEGAVRCMKMAMHGVDTPIDYLNSHGTSTPV-----GDVKELAAIRE 315 G D + + +G+G M G Y NS T+ GD E A+ Sbjct: 157 GKNQDNHSINSQNGDGVGYTMAYEFDGFGVTAAYSNSKRTNDQQDRDGNGDRAESRAVGA 216 Query: 316 VFGDKSPAISATKAMT 331 + + ++A A T Sbjct: 217 KYDANNVYLAAVYAET 232 >3LS2-A nrPDB Length = 280 Score = 33.1 bits (74), Expect = 0.26, Method: Composition-based stats. Identities = 16/56 (28%), Positives = 27/56 (48%), Gaps = 14/56 (25%) Query: 294 YLNSHGTSTPVGD--------VKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQ 341 Y+N+ T P V EL A+ ++ +++TKA++GHS+G G Sbjct: 105 YVNA--TQAPYNTHFNMYDYVVNELPALI----EQHFPVTSTKAISGHSMGGHGAL 154 >2WUA-A nrPDB Length = 440 Score = 32.7 bits (73), Expect = 0.32, Method: Composition-based stats. Identities = 28/119 (23%), Positives = 44/119 (36%), Gaps = 21/119 (17%) Query: 231 IAGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAPS--GEGAVRCMKMAMHGV 288 ++ G G V++ + AL +G I + A V PS G G + A+ Sbjct: 277 VSDGAGAVLLMKRSIALQKGLPILGVFRTFAAVG-----VPPSIMGIGPAVAIPAAVKAA 331 Query: 289 DTPIDYLNSHGTSTPVGDVKELAAIREVFGDKSPAISATK-------AMTGHSLGAAGV 340 ID ++ + ++ E A + V+ K I K GH LGA G Sbjct: 332 GLQIDDID-------LFEINEAFASQFVYCQKKLEIDPQKINVNGGAMAIGHPLGATGA 383 >1WDK-C nrPDB Length = 390 Score = 32.7 bits (73), Expect = 0.32, Method: Composition-based stats. Identities = 13/54 (24%), Positives = 20/54 (37%), Gaps = 2/54 (3%) Query: 138 MASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGE 191 +A S P ++S C +S + A + I G D+ GG E Sbjct: 71 IARMASLMTQIPH--TSAAQTVSRLCGSSMSALHTAAQAIMTGNGDVFVVGGVE 122 >1UB7-A nrPDB Length = 322 Score = 32.7 bits (73), Expect = 0.34, Method: Composition-based stats. Identities = 12/60 (20%), Positives = 22/60 (36%) Query: 135 TKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELC 194 A+ +A + F + Y + + C + + A ++ G V A G E L Sbjct: 82 PDALFPDTAALVQARFGLKAFAYDLLAGCPGWIYALAQAHALVEAGLAQKVLAVGAEALS 141 >3LM6-A nrPDB Length = 346 Score = 32.3 bits (72), Expect = 0.40, Method: Composition-based stats. Identities = 28/193 (14%), Positives = 58/193 (30%), Gaps = 31/193 (16%) Query: 140 SGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMAC 199 + + +A KI + AC+TS + A + G A A Sbjct: 89 NVTANYVARHLKI--PFLCMFGACSTSMETVAVASALVDGGFAKRALA----ATSSHNAT 142 Query: 200 EFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVVEELEHALARGAHIYAEIVG 259 + P+ A+ T G G VV+ + + + ++ Sbjct: 143 AERQFRYPTEYGGQKPDTATSTVT----------GSGAVVISQTPGDIQITSATVGKVSD 192 Query: 260 YGATSDGADMVAPSGEGAVRCMK---MAMHGVDTPIDYL---NSHGTSTPVGDVKELAAI 313 G T D DM + A +K ++ D + + G +P+ + Sbjct: 193 LGIT-DPFDMGSAMAPAAADTIKQHFKDLNRTADDYDLILTGDLSGVGSPI--------V 243 Query: 314 REVFGDKSPAISA 326 +++ + + Sbjct: 244 KDILKEDGYPVGT 256 >5VXG-A nrPDB Length = 358 Score = 31.9 bits (71), Expect = 0.47, Method: Composition-based stats. Identities = 24/206 (11%), Positives = 55/206 (26%), Gaps = 22/206 (10%) Query: 46 SHVWGNVKLDTTGLIDRKVV--RFMSDASIYAF---LSMEQAIADAG--LSPEAYQNNPR 98 + G +D + K + R + + A A + ++ Sbjct: 26 VSIAGLAHIDAPHTLTSKEINERLQPTYDRLGIKTDVLGDVAGIHARRLWDQDVQASDAA 85 Query: 99 VGLIAGSGGGSPRFQVFGADAMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYS 158 + + + V + + AS VS L + + Sbjct: 86 TQAARKALIDANIGIEKIGLLINTS-----VSRDYLQPSTASIVSGNLGVSDHC--MTFD 138 Query: 159 ISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKA 218 +++AC + + A ++ G+ D GE + M + P+ Sbjct: 139 VANACLAFINGMDIAARMLERGEIDYALVVDGETANLVYEKTLERMTS--------PDVT 190 Query: 219 SRTYDAHRDGFVIAGGGGMVVVEELE 244 + + G +V+ E Sbjct: 191 EEEFRNELAALTLGCGAAAMVMARSE 216 >3MW8-A nrPDB Length = 240 Score = 31.5 bits (70), Expect = 0.65, Method: Composition-based stats. Identities = 11/61 (18%), Positives = 23/61 (37%) Query: 266 GADMVAPSGEGAVRCMKMAMHGVDTPIDYLNSHGTSTPVGDVKELAAIREVFGDKSPAIS 325 G +V G+G M + + YL + + P D + + FG + ++ Sbjct: 120 GKQIVIVRGKGGREAMADGLRLRGANVSYLEVYQRACPPLDAPASVSRWQSFGIDTIVVT 179 Query: 326 A 326 + Sbjct: 180 S 180 >2JB5-L nrPDB Length = 216 Score = 31.5 bits (70), Expect = 0.65, Method: Composition-based stats. Identities = 19/105 (18%), Positives = 41/105 (39%), Gaps = 14/105 (13%) Query: 155 VNYSISSACATSAHCIGN----AVEQIQLGKQ-DIVFAGGGEELCWEMACEFDAMGALST 209 SI+ +C ++ +G+ + Q GK ++ GG ++ F + +T Sbjct: 14 PGQSITISCTGTSSDVGSNNYVSWYQQHPGKAPKLMIYGGSNRPS-GVSNRFSGSKSGNT 72 Query: 210 KY--------NDTPEKASRTYDAHRDGFVIAGGGGMVVVEELEHA 246 D + R++D++ V GG + V+ + + A Sbjct: 73 ASLTISGLQAEDEADYYCRSWDSNLSYSVFGGGTKLTVLGQPKAA 117 >3IL3-A nrPDB Length = 323 Score = 31.5 bits (70), Expect = 0.69, Method: Composition-based stats. Identities = 16/102 (15%), Positives = 39/102 (38%), Gaps = 23/102 (22%) Query: 154 GVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACEFDAMGALSTKYND 213 +++ +++AC + + A + I+ GK G + L+++ D Sbjct: 110 AISFDLAAACTGFVYALSVADQFIRAGKVKKALVIGSD---------------LNSRKLD 154 Query: 214 TPEKASRTYDAHRDGFVIAGGGGMVVVEELEHALARGAHIYA 255 ++++ + G G V++E E H++A Sbjct: 155 ETDRSTV--------VLFGDGAGAVILEASEQEGIISTHLHA 188 >6BJB-A nrPDB Length = 393 Score = 31.5 bits (70), Expect = 0.70, Method: Composition-based stats. Identities = 21/118 (17%), Positives = 42/118 (35%), Gaps = 17/118 (14%) Query: 230 VIAGGGGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVD 289 + G MVV+ ++ A G A ++ YG D A G + + Sbjct: 251 TLNDGAAMVVMTTVDGAKKHGLKPLARMLAYG---DAATHPIDFGIAPASVIPKVLKLAG 307 Query: 290 TPIDYLNSHGTSTPVGDVKELAAIREVFGDKSPAISATKAMT-------GHSLGAAGV 340 I ++ + ++ E A+ ++ K+ + +K GH +G +G Sbjct: 308 LQIKDID-------LWEINEAFAVVPLYTMKTLGLDESKVNIHGGAVSLGHPIGMSGA 358 >6BJA-A nrPDB Length = 397 Score = 31.1 bits (69), Expect = 0.82, Method: Composition-based stats. Identities = 12/42 (28%), Positives = 20/42 (47%) Query: 156 NYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEM 197 +I+ C++S I + IQ+G + IV A G E + Sbjct: 88 CVTINKVCSSSMKAIIMGAQAIQVGYRRIVVALGSESMSNAP 129 >4DFE-A nrPDB Length = 333 Score = 31.1 bits (69), Expect = 0.93, Method: Composition-based stats. Identities = 26/150 (17%), Positives = 47/150 (31%), Gaps = 38/150 (25%) Query: 74 YAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAMRGPRGLKAVGPYV 133 AF++ ++AI A + P+ S + P Sbjct: 68 LAFIASQRAIEAADIDPQ-----------------SIDLIIVATST-----------PDF 99 Query: 134 VTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEEL 193 V + A + L HG + + + C+ A+ + A I+ G+ G E Sbjct: 100 VFPSTACLLQNKLGIRN--HGAAFDVQAVCSGFAYAVATADSFIRSGQHRTALVIGAETF 157 Query: 194 CWEM-------ACEF-DAMGALSTKYNDTP 215 + F D GA+ + +D P Sbjct: 158 SRILDFKDRTTCVLFGDGAGAVILQASDEP 187 >3JC8-Ba nrPDB Length = 566 Score = 30.7 bits (68), Expect = 1.0, Method: Composition-based stats. Identities = 13/61 (21%), Positives = 24/61 (39%) Query: 331 TGHSLGAAGVQEAIYSLLMLEHGFIAPSINIEELDEQAAGLNIVTETTDRELTTVMSNSF 390 G +L G E L + P+IN+++ D + + +V + + V N Sbjct: 34 IGTALVKTGAIEESKLTDFLSKQYGVPAINLKDFDVEPDIIKLVPKEVAEKHLVVPVNRA 93 Query: 391 G 391 G Sbjct: 94 G 94 >1D4E-A nrPDB Length = 572 Score = 30.7 bits (68), Expect = 1.1, Method: Composition-based stats. Identities = 18/88 (20%), Positives = 29/88 (32%), Gaps = 3/88 (3%) Query: 230 VIAGGGGMVVVEELEHALARG--AHIYAEIVGYGATSDGADMVA-PSGEGAVRCMKMAMH 286 V G V++ +A G A + Y G P G + + Sbjct: 294 VKGEYTGYYVIKADAVVIAAGGFAKNNERVSKYDPKLKGFKATNHPGATGDGLDVALQAG 353 Query: 287 GVDTPIDYLNSHGTSTPVGDVKELAAIR 314 + Y+ +H T +P G V A+R Sbjct: 354 AATRDLQYIQAHPTYSPAGGVMITEAVR 381 >4O9A-A nrPDB Length = 398 Score = 30.4 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 22/122 (18%), Positives = 36/122 (29%), Gaps = 30/122 (24%) Query: 70 DASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAMRGPRGLKAV 129 A + ++ A+ AG+ PE ++ G +P Q + Sbjct: 30 PAPELGAVVIKAALERAGVKPEQVSEVIMGQVLTAGSGQNPARQAAIKAGL--------- 80 Query: 130 GPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGG 189 P +V + VS + + A I G +IV AGG Sbjct: 81 -PAMVPAMTINKVSG--------------------SGLKAVMLAANAIMAGDAEIVVAGG 119 Query: 190 GE 191 E Sbjct: 120 QE 121 >2C7Y-A nrPDB Length = 404 Score = 30.4 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 23/118 (19%), Positives = 43/118 (36%), Gaps = 19/118 (16%) Query: 231 IAGGGGMVVVEELEHALARGAHIYAEIVGYGATS-DGADMVAPSGEGAVRCMKMAMHGVD 289 ++ G G V++ + A+ +G + + A D A M G G + A+ Sbjct: 257 VSDGAGAVLLMKRSVAMQKGLPVLGVFRTFAAVGVDPAIM----GIGPAVAIPAAVKAAG 312 Query: 290 TPIDYLNSHGTSTPVGDVKELAAIREVFGDKSPAISATK-------AMTGHSLGAAGV 340 +D ++ + ++ E A + V+ + K GH LGA G Sbjct: 313 LELDDID-------LFEINEAFASQFVYCRNKLGLDPEKINVNGGAMAIGHPLGATGA 363 >5C4I-A nrPDB Length = 395 Score = 30.4 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 25/137 (18%), Positives = 41/137 (29%), Gaps = 26/137 (18%) Query: 165 TSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDA 224 + + + V D++ + + E Sbjct: 8 SGCVAVAHGVRLA---DVDVI----CSYPIRPYTGIMSELARMVADGELDAE-------- 52 Query: 225 HRDGFVIAGG--GGMVVVEELEHALARGAHIYAEIVGYGATSDGADMVAP-SGEGAVRCM 281 FV G + VV A A GA ++ G G T ++ +P SGE M Sbjct: 53 ----FVHGEGEHAQLSVVYG---ASAAGARVFTGSSGVGVTY-AMEVYSPISGERLPVQM 104 Query: 282 KMAMHGVDTPIDYLNSH 298 +A +D P D+ H Sbjct: 105 AIADRTLDPPGDFGEEH 121 >5B8I-B nrPDB Length = 171 Score = 30.4 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 20/71 (28%), Positives = 31/71 (43%), Gaps = 10/71 (14%) Query: 173 AVEQIQLGKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEK--ASRTYDAHRDGFV 230 + I + +D GGG+ E A S+K N + A + YD RDGF Sbjct: 55 STRMIAIFDED----GGGDVDFQEFVSGLS---AFSSKGNKEEKLRFAFKVYDIDRDGF- 106 Query: 231 IAGGGGMVVVE 241 I+ G +V++ Sbjct: 107 ISNGELFIVLK 117 >1PXT-A nrPDB Length = 390 Score = 30.4 bits (67), Expect = 1.7, Method: Composition-based stats. Identities = 12/52 (23%), Positives = 26/52 (50%) Query: 143 SACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELC 194 +ACLA+ +++ C++ + + +I++G+ DI A G E + Sbjct: 78 AACLASGIPYSTPFVALNRQCSSGLTAVNDIANKIKVGQIDIGLALGVESMT 129 >5YO9-A nrPDB Length = 371 Score = 30.0 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 22/137 (16%), Positives = 47/137 (34%), Gaps = 35/137 (25%) Query: 54 LDTTGLIDRKVVRFMSDASI---YAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSP 110 LD T L R R + SI + ++ +QA+ +AG++ E Sbjct: 78 LDPTRLRPRLSERSNDELSIQAEWGVIAAKQAMENAGVTAEDID---------------- 121 Query: 111 RFQVFGADAMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCI 170 + ++ P V+ + + I G Y ++ A + + + Sbjct: 122 -------VVILACSNMQRAYP---------AVAIEIQSALGIQGYAYDMNVAASAATFGL 165 Query: 171 GNAVEQIQLGKQDIVFA 187 A + I+ G + ++ Sbjct: 166 KQAADAIRSGARRVLLV 182 >5LNQ-A nrPDB Length = 457 Score = 30.0 bits (66), Expect = 2.2, Method: Composition-based stats. Identities = 10/44 (22%), Positives = 17/44 (38%) Query: 155 VNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMA 198 + A A+ + +A+ ++ G DI A G E A Sbjct: 131 PAMRVEGAAASGGLAVISAMNALKSGSADITLAVGVEVQTTASA 174 >3CN7-A nrPDB Length = 226 Score = 29.6 bits (65), Expect = 2.3, Method: Composition-based stats. Identities = 36/206 (17%), Positives = 60/206 (29%), Gaps = 34/206 (16%) Query: 142 VSACLATPFKIHGVNYSISSACATSAHCIGNAVEQI--QLGKQDIVFAGGGEELCWEMAC 199 AC+ + G + + A + + + I Q Q + GG W Sbjct: 23 ADACIIWLHGL-GADRTDFKPVAEALQMVLPSTRFILPQAPSQAVTVNGGWVMPSWYDIL 81 Query: 200 EFDAMGALST-KYNDTPEKASRTYDAHRDGFVIAG--------GGGMVVVEELEHALARG 250 F A+ + N + ++ D R + A GG VV+ A R Sbjct: 82 AFSPARAIDEDQLNASADQVIALIDEQRAKGIAAERIILAGFSQGGAVVLHT---AFRRY 138 Query: 251 AHIYAEIVG---YGATSDGADMVAPSGEGAVRCMKMAMHGVDTPIDYLNSHGTSTPVGDV 307 A ++ Y T D +A+ I L+ HG+ V D Sbjct: 139 AQPLGGVLALSTYAPTFD----------------DLALDERHKRIPVLHLHGSQDDVVDP 182 Query: 308 KELAAIREVFGDKSPAISATKAMTGH 333 A + + + GH Sbjct: 183 ALGRAAHDALQAQGVEVGWHDYPMGH 208 >2PP0-A nrPDB Length = 398 Score = 29.6 bits (65), Expect = 2.4, Method: Composition-based stats. Identities = 13/53 (24%), Positives = 20/53 (37%), Gaps = 2/53 (3%) Query: 283 MAMHGVDTPIDYLNSHGTSTPV--GDVKELAAIREVFGDKSPAISATKAMTGH 333 MA+ + Y + T T GD E + F + +S K +TG Sbjct: 1 MALSANSDAVTYAKAANTRTAAETGDRIEWVKLSLAFLPLATPVSDAKVLTGR 53 >5BQS-A nrPDB Length = 323 Score = 29.6 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 20/116 (17%), Positives = 34/116 (29%), Gaps = 25/116 (21%) Query: 135 TKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELC 194 M S + A + +++AC+ + A + I G+ G E L Sbjct: 83 DSMMPSTAARVQANIGANKAFAFDLTAACSGFVFALSTAEKFIASGRFQKGLVIGSETLS 142 Query: 195 WEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVVE--ELEHALA 248 + + + G G V++E E EH LA Sbjct: 143 KAVD-----------------------WSDRSTAVLFGDGAGGVLLEASEQEHFLA 175 >1GGZ-A nrPDB Length = 148 Score = 29.6 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 8/35 (22%), Positives = 12/35 (34%) Query: 196 EMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFV 230 A T + +A R +D +GFV Sbjct: 66 PEFLGMMARKMKDTDNEEEIREAFRVFDKDGNGFV 100 >2Z0F-A nrPDB Length = 524 Score = 29.6 bits (65), Expect = 2.9, Method: Composition-based stats. Identities = 40/258 (15%), Positives = 68/258 (26%), Gaps = 58/258 (22%) Query: 12 VSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLIDRKVVRFMSDA 71 V +G V L E G+ + + + + + + M + Sbjct: 215 VDPLGGASLRVWERLAE-SHGL-PLEVVNPTLDPTF-----RFMPKDHDGKI---RMDCS 264 Query: 72 SIYAFLSMEQAIADA-GLSPEAYQNNPRVGLIAGSGGGSPRFQVFGA----DAMRGPRGL 126 S YA + A+ D L+ + R G++ G +P + A R G Sbjct: 265 SPYAM-AGLLALKDRFDLAIGNDPDADRHGIVTPRGLMNPNHYLAAALHHLYTTRSWPG- 322 Query: 127 KAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVF 186 VG VT A+ V+ L + G + Sbjct: 323 AKVGKTAVTSALLDRVAQALGREV-YETPV----------------GFKHFVAGLLEGWL 365 Query: 187 AGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVVEE---- 242 GEE FD R + +DG ++ ++ + Sbjct: 366 GFAGEESAGASFLRFDG----------------RPFSTDKDGILMGLLAAELMAKRGQAP 409 Query: 243 ----LEHALARGAHIYAE 256 A G YA Sbjct: 410 DALYEALAEKLGRPYYAR 427 >1ULQ-A nrPDB Length = 401 Score = 29.2 bits (64), Expect = 3.3, Method: Composition-based stats. Identities = 6/41 (14%), Positives = 14/41 (34%) Query: 158 SISSACATSAHCIGNAVEQIQLGKQDIVFAGGGEELCWEMA 198 +++ C + + A I G+ + G E + Sbjct: 84 TVNRLCGSGLEAVAQAARAIWAGEGKVYIGSGVESMSRAPY 124 >3IL7-A nrPDB Length = 313 Score = 29.2 bits (64), Expect = 3.5, Method: Composition-based stats. Identities = 37/197 (18%), Positives = 65/197 (32%), Gaps = 62/197 (31%) Query: 70 DASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAMRGPRGLKAV 129 D S A+ + +AIADAG+ PE +I + G F Sbjct: 50 DTSDLAYEASVKAIADAGIQPEDID-----MIIVATATGDMPF----------------- 87 Query: 130 GPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLGKQDIVFAGG 189 P V + +A + +AC+ + + A + +Q G + G Sbjct: 88 -PTVANMLQERLGTGKVA--------SMDQLAACSGFMYSMITAKQYVQSGDYHNILVVG 138 Query: 190 GEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVVEELEHALAR 249 ++L +K D ++++ + G G V++ E+ R Sbjct: 139 ADKL---------------SKITDLTDRST--------AVLFGDGAGAVIIGEVS--EGR 173 Query: 250 GAHIYAEIVGYGATSDG 266 G I+ Y SDG Sbjct: 174 G------IISYEMGSDG 184 >6ESQ-I nrPDB Length = 349 Score = 28.8 bits (63), Expect = 4.6, Method: Composition-based stats. Identities = 17/54 (31%), Positives = 22/54 (40%), Gaps = 7/54 (12%) Query: 243 LEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDTPIDYLN 296 L+HA GA I A G GA SD D+ +K + +D LN Sbjct: 284 LDHAE-EGARILAVSYGSGAGSDAFDITVTE------RIKEVVDKAPKTLDLLN 330 >5UTH-A nrPDB Length = 319 Score = 28.4 bits (62), Expect = 5.2, Method: Composition-based stats. Identities = 23/114 (20%), Positives = 34/114 (29%), Gaps = 5/114 (4%) Query: 107 GGSPRFQVFGADAMRGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATS 166 G R + A + GP VG A + G +T Sbjct: 86 GADLRMEDVDAVQLEGPVKTVVVGDETHQARAVILAMGAAARHLGVPGEEALTGMGVSTC 145 Query: 167 AHCIGNAVEQIQLGKQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASR 220 A C G QDIV GGG+ E +++ + +AS+ Sbjct: 146 ATCDGFFFR-----DQDIVVVGGGDSAMEEATFLTRFARSVTLIHRRDEFRASK 194 >5XN6-C nrPDB Length = 304 Score = 28.4 bits (62), Expect = 5.8, Method: Composition-based stats. Identities = 13/47 (27%), Positives = 21/47 (44%), Gaps = 3/47 (6%) Query: 294 YLNSHGTSTPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGV 340 ++ +H TP D A + V G+ + A+ +T G L AG Sbjct: 129 HVIAH---TPSPDPVPHAVLLRVLGELARAVGSTGMAAGQFLDLAGA 172 >4MTS-A nrPDB Length = 131 Score = 28.0 bits (61), Expect = 6.6, Method: Composition-based stats. Identities = 14/47 (29%), Positives = 21/47 (44%), Gaps = 7/47 (14%) Query: 225 HRDGFVIAGGGGMVVVEELEHAL--ARGAHIYAEIVGYGATSDGADM 269 RDG+ G G + +E + A+ AR A +GY T + M Sbjct: 62 DRDGYTQGDGYGHLAIEVEDAAVTCAR-----ARALGYRVTREAGLM 103 >4KXR-A nrPDB Length = 101 Score = 28.0 bits (61), Expect = 7.3, Method: Composition-based stats. Identities = 11/22 (50%), Positives = 12/22 (54%) Query: 234 GGGMVVVEELEHALARGAHIYA 255 VV+EE HAL GA YA Sbjct: 69 AAAAVVLEEFAHALTTGADKYA 90 >3TL2-A nrPDB Length = 315 Score = 27.7 bits (60), Expect = 8.6, Method: Composition-based stats. Identities = 21/91 (23%), Positives = 25/91 (27%), Gaps = 18/91 (19%) Query: 224 AHRDGFVIAG-GGGMVVV-----------------EELEHALARGAHIYAEIVGYGATSD 265 GFV+ G G MV + E LE + R EIVG Sbjct: 173 KDITGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERLEAIVERTRKGGGEIVGLLGNGS 232 Query: 266 GADMVAPSGEGAVRCMKMAMHGVDTPIDYLN 296 A S + V I YL Sbjct: 233 AYYAPAASLVEMTEAILKDQRRVLPAIAYLE 263 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.307 0.140 0.380 Lambda K H 0.267 0.0432 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,825,329 Number of Sequences: 36641 Number of extensions: 654990 Number of successful extensions: 2614 Number of sequences better than 10.0: 103 Number of HSP's better than 10.0 without gapping: 108 Number of HSP's successfully gapped in prelim test: 39 Number of HSP's that attempted gapping in prelim test: 2145 Number of HSP's gapped (non-prelim): 178 length of query: 406 length of database: 10,336,785 effective HSP length: 99 effective length of query: 307 effective length of database: 6,709,326 effective search space: 2059763082 effective search space used: 2059763082 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.0 bits) S2: 60 (27.6 bits)