BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P0A6D3 (427 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3FJZ-A nrPDB 879 0.0 3NVS-A nrPDB 649 0.0 5XWB-A nrPDB 592 e-169 1P88-A nrPDB 441 e-124 3TI2-A nrPDB 320 6e-88 3SLH-A nrPDB 152 2e-37 5BS5-A nrPDB 152 3e-37 2O0B-A nrPDB 148 5e-36 3RMT-A nrPDB 142 2e-34 1RF6-A nrPDB 121 6e-28 2GG4-A nrPDB 118 6e-27 5U4H-A nrPDB 75 4e-14 2Z2C-A nrPDB 56 3e-08 6CN1-A nrPDB 54 1e-07 2RL1-A nrPDB 50 1e-06 3VCY-A nrPDB 50 2e-06 5BQ2-A nrPDB 43 3e-04 3R38-A nrPDB 40 0.003 3SG1-A nrPDB 39 0.006 2YVW-A nrPDB 38 0.011 5WI5-A nrPDB 37 0.012 5Z74-B nrPDB 34 0.16 1A8Q-A nrPDB 31 1.2 3KUK-A nrPDB 30 2.8 3TQI-A nrPDB 29 3.9 5UJS-A nrPDB 29 3.9 3KQA-A nrPDB 29 5.1 3EUF-A nrPDB 28 5.5 >3FJZ-A nrPDB Length = 427 Score = 879 bits (2270), Expect = 0.0, Method: Compositional matrix adjust. Identities = 426/427 (99%), Positives = 426/427 (99%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL Sbjct: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 Query: 61 GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPR 120 GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAG AMRPLAAALCLGSNDIVLTGEPR Sbjct: 61 GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGIAMRPLAAALCLGSNDIVLTGEPR 120 Query: 121 MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTA 180 MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTA Sbjct: 121 MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTA 180 Query: 181 PLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE 240 PLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE Sbjct: 181 PLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE 240 Query: 241 GDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGE 300 GDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGE Sbjct: 241 GDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGE 300 Query: 301 LNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVE 360 LNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVE Sbjct: 301 LNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVE 360 Query: 361 EGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQL 420 EGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQL Sbjct: 361 EGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQL 420 Query: 421 ARISQAA 427 ARISQAA Sbjct: 421 ARISQAA 427 >3NVS-A nrPDB Length = 450 Score = 649 bits (1675), Expect = 0.0, Method: Compositional matrix adjust. Identities = 321/426 (75%), Positives = 359/426 (84%), Gaps = 1/426 (0%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 MESLTLQPI + G +NLPGSKSVSNRALLLAALA G T LTNLLDSDD+RHMLNALT L Sbjct: 25 MESLTLQPIELISGEVNLPGSKSVSNRALLLAALASGTTRLTNLLDSDDIRHMLNALTKL 84 Query: 61 GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPR 120 GV+Y LSAD+T CE+ G G H LELFLGNAGTAMRPLAAALCLG D VLTGEPR Sbjct: 85 GVNYRLSADKTTCEVEGLGQAFHTTQPLELFLGNAGTAMRPLAAALCLGQGDYVLTGEPR 144 Query: 121 MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQG-GFTGGNVDVDGSVSSQFLTALLMT 179 MKERPIGHLVDALR GA+I YLEQEN+PPLR+QG G G V +DGS+SSQFLTA LM+ Sbjct: 145 MKERPIGHLVDALRQAGAQIEYLEQENFPPLRIQGTGLQAGTVTIDGSISSQFLTAFLMS 204 Query: 180 APLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLV 239 APLA I+I G+LVSKPYIDITL++M+ FGV++ N YQ+FV+ GQSY SPG +LV Sbjct: 205 APLAQGKVTIKIVGELVSKPYIDITLHIMEQFGVQVINHDYQEFVIPAGQSYVSPGQFLV 264 Query: 240 EGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRG 299 EGDASSASYFLAAAAIKGG VKVTGIG+NS+QGDI+FAD LEKMGA I WGDDY+ RG Sbjct: 265 EGDASSASYFLAAAAIKGGEVKVTGIGKNSIQGDIQFADALEKMGAQIEWGDDYVIARRG 324 Query: 300 ELNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEV 359 ELNA+D+D NHIPDAAMTIAT ALFAKGTT +RN+YNWRVKETDRL AMATELRKVGA V Sbjct: 325 ELNAVDLDFNHIPDAAMTIATTALFAKGTTAIRNVYNWRVKETDRLAAMATELRKVGATV 384 Query: 360 EEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQ 419 EEG D+I ITPP KL A I TY+DHRMAMCFSLVALSDTPVTI DPKCT+KTFPDYF++ Sbjct: 385 EEGEDFIVITPPTKLIHAAIDTYDDHRMAMCFSLVALSDTPVTINDPKCTSKTFPDYFDK 444 Query: 420 LARISQ 425 A++S+ Sbjct: 445 FAQLSR 450 >5XWB-A nrPDB Length = 446 Score = 592 bits (1525), Expect = e-169, Method: Compositional matrix adjust. Identities = 291/425 (68%), Positives = 339/425 (79%), Gaps = 1/425 (0%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 ME LTL PI +++G I LPGSKS+SNRALL+AALA+G T +TNLL SDD+ HMLNAL +L Sbjct: 21 MEQLTLNPIGKINGEIFLPGSKSLSNRALLIAALANGVTKITNLLVSDDINHMLNALKSL 80 Query: 61 GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPR 120 G+ YTLS T C +IGNGG +A+ LEL+LGNAGTAMRPL AAL + +LTGEPR Sbjct: 81 GIEYTLSDCGTECTVIGNGGFFNAKKPLELYLGNAGTAMRPLCAALAASEGEFILTGEPR 140 Query: 121 MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQG-GFTGGNVDVDGSVSSQFLTALLMT 179 MKERPIGHLVDAL A I YLE ++YPP++++G TG V +DGS+SSQFLTA+LM Sbjct: 141 MKERPIGHLVDALAQLDADIEYLENKDYPPVKIKGKALTGNTVTIDGSISSQFLTAILMI 200 Query: 180 APLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLV 239 APL +T I I G+LVSKPYIDITL++M+ F V ++N Y+ F+V G QSYQ+ Y+V Sbjct: 201 APLLETNTTIEIDGELVSKPYIDITLDIMRRFNVSVQNNDYKSFIVNGKQSYQALDKYMV 260 Query: 240 EGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRG 299 EGDASSASYFLAA AIKGG V V GIG+ S+QGD FADVLEKMGA I W D+ I+ Sbjct: 261 EGDASSASYFLAAGAIKGGEVTVHGIGKLSVQGDKHFADVLEKMGAEIHWKDESITVIGK 320 Query: 300 ELNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEV 359 L A+DMDMNHIPDAAMTIAT ALFA GTTT+RNIYNWRVKETDRL AMATELRKVGAEV Sbjct: 321 PLTAVDMDMNHIPDAAMTIATTALFATGTTTIRNIYNWRVKETDRLNAMATELRKVGAEV 380 Query: 360 EEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQ 419 EG DYI ITPP+ L AEI TYNDHR+AMCFSLVALSDTPVTI DPKCTAKTFPDYF++ Sbjct: 381 VEGKDYISITPPKSLKHAEIDTYNDHRVAMCFSLVALSDTPVTINDPKCTAKTFPDYFDK 440 Query: 420 LARIS 424 LA++S Sbjct: 441 LAQVS 445 >1P88-A nrPDB Length = 216 Score = 441 bits (1135), Expect = e-124, Method: Compositional matrix adjust. Identities = 216/216 (100%), Positives = 216/216 (100%) Query: 25 SNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLHA 84 SNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLHA Sbjct: 1 SNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLHA 60 Query: 85 EGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVDALRLGGAKITYLE 144 EGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVDALRLGGAKITYLE Sbjct: 61 EGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVDALRLGGAKITYLE 120 Query: 145 QENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDIT 204 QENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDIT Sbjct: 121 QENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDIT 180 Query: 205 LNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE 240 LNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE Sbjct: 181 LNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE 216 >3TI2-A nrPDB Length = 228 Score = 320 bits (821), Expect = 6e-88, Method: Compositional matrix adjust. Identities = 165/228 (72%), Positives = 186/228 (81%), Gaps = 1/228 (0%) Query: 16 INLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEI 75 +NLPGSKSVSNRALLLAALA G T LTNLLDSDD+RHMLNALT LGV+Y LSAD+T CE+ Sbjct: 1 VNLPGSKSVSNRALLLAALASGTTRLTNLLDSDDIRHMLNALTKLGVNYRLSADKTTCEV 60 Query: 76 IGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVDALRL 135 G G H LELFLGNAGTAMRPLAAALCLG D VLTGEPRMKERPIGHLVDALR Sbjct: 61 EGLGQAFHTTQPLELFLGNAGTAMRPLAAALCLGQGDYVLTGEPRMKERPIGHLVDALRQ 120 Query: 136 GGAKITYLEQENYPPLRLQG-GFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGD 194 GA+I YLEQEN+PPLR+QG G G V +DGS+SSQFLTA LM+APLA I+I G+ Sbjct: 121 AGAQIEYLEQENFPPLRIQGTGLQAGTVTIDGSISSQFLTAFLMSAPLAQGKVTIKIVGE 180 Query: 195 LVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGD 242 LVSKPYIDITL++M+ FGV++ N YQ+FV+ GQSY SPG +LVEGD Sbjct: 181 LVSKPYIDITLHIMEQFGVQVINHDYQEFVIPAGQSYVSPGQFLVEGD 228 >3SLH-A nrPDB Length = 441 Score = 152 bits (384), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 135/428 (31%), Positives = 206/428 (48%), Gaps = 31/428 (7%) Query: 8 PIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLS 67 P + G I +PG KS+S+RA+LLAA+A G+T + L D M++AL +G S + Sbjct: 10 PSQGLSGEICVPGDKSISHRAVLLAAIAEGQTQVDGFLMGADNLAMVSALQQMGASIQVI 69 Query: 68 ADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIG 127 D + G G L GN+GTA+R L+ L + VLTG+ ++ RP+ Sbjct: 70 EDENILVVEGVGMTGLQAPPEALDCGNSGTAIRLLSGLLAGQPFNTVLTGDSSLQRRPMK 129 Query: 128 HLVDALRLGGAKITYLEQENYPPLRLQGG--FTGGNVDVDGSVSSQFLTALLMTAPLAPE 185 ++D L L GAKI N PPL++ G TG + + S+Q + LL+ A Sbjct: 130 RIIDPLTLMGAKID--STGNVPPLKIYGNPRLTGIHYQLP-MASAQVKSCLLLAGLYARG 186 Query: 186 DTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDASS 245 T I P D T L+K F ++ + Q V GG ++ + GD SS Sbjct: 187 KTCIT-----EPAPSRDHTERLLKHFHYTLQ-KDKQSICVSGGGKLKA-NDISIPGDISS 239 Query: 246 ASYFLAAAAI-KGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDY----------I 294 A++F+ AA I G +++ +G N + + ++L+ MGA I Y I Sbjct: 240 AAFFIVAATITPGSAIRLCRVGVNPTR--LGVINLLKMMGADIEV-THYTEKNEEPTADI 296 Query: 295 SCTRGELNAIDMDMNHIP---DAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATE 351 + L ID+ + +P D + AA A+G T LR+ RVKETDR+ AM Sbjct: 297 TVRHARLKGIDIPPDQVPLTIDEFPVLLIAAAVAQGKTVLRDAAELRVKETDRIAAMVDG 356 Query: 352 LRKVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVA-LSDTPVTILDPKCTA 410 L+K+G E D + I L E+ +Y+DHR+AM F++ L+ PV I + Sbjct: 357 LQKLGIAAESLPDGV-IIQGGTLEGGEVNSYDDHRIAMAFAVAGTLAKGPVRIRNCDNVK 415 Query: 411 KTFPDYFE 418 +FP++ E Sbjct: 416 TSFPNFVE 423 >5BS5-A nrPDB Length = 445 Score = 152 bits (384), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 130/436 (29%), Positives = 214/436 (49%), Gaps = 41/436 (9%) Query: 14 GTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRC 73 G +PG KSVS+R+++ A+A G T +T L+ +D L A +GVS + Sbjct: 15 GKFTVPGDKSVSHRSIMFGAIAEGTTHVTGFLEGEDALATLQAFRDMGVSIEGPKN---G 71 Query: 74 EIIGNGGPLHA--EGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVD 131 E+ +G +H A L++GN+GT+MR L+ L D V+TG+ + +RP+ + Sbjct: 72 EVTIHGVGMHGLKAPASALYMGNSGTSMRLLSGMLSAQKFDSVMTGDASLSKRPMERIAK 131 Query: 132 ALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSS-QFLTALLMTAPLAPEDTVIR 190 LRL GA+I ++ PP+ + GG + D ++S Q + +L+ A +T + Sbjct: 132 PLRLMGAQIQTTGEKGTPPVSITGGQQLKGIQYDLPMASAQVKSGILLAGLWAEGETSVT 191 Query: 191 IKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYL-VEGDASSASYF 249 +P D T +++ FG +++ + + +V GG+ GT + V D SSA++F Sbjct: 192 -----EPEPTRDHTERMLRAFGYDVKTEGNKISLVGGGKLV---GTNIQVPSDISSAAFF 243 Query: 250 LAAAAI-KGGTVKVTGIGRNSMQGDIRFADVLEKMGATIC-----------WGDDYISCT 297 + AAI +G V + +G N + + ++L++MGA + D +I + Sbjct: 244 MVGAAITEGADVVLEAVGINPTRTGV--IEILKQMGADLTVENERIAGGEPIADIHIKGS 301 Query: 298 RGELNAIDMDMNHIP---DAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRK 354 R L I M + +P D + AA A+G T L RVKE+DR+ MA L+ Sbjct: 302 R-TLKGIHMPEDQVPLAIDEFPALFIAAACAEGQTVLTGAAELRVKESDRIQVMADGLKI 360 Query: 355 VGAEVEEGHDYIRITPPEKLN-----FA--EIATYNDHRMAMCFSLVAL-SDTPVTILDP 406 +G + D I I K FA EI +++DHR+AM FS+ L + P+TI Sbjct: 361 MGIDCTPTEDGIIIEGKGKSGDWSPIFAGGEIESHHDHRIAMSFSMAGLRTSGPITIHGT 420 Query: 407 KCTAKTFPDYFEQLAR 422 + A +FP + E R Sbjct: 421 ETVATSFPTFTELANR 436 >2O0B-A nrPDB Length = 450 Score = 148 bits (373), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 132/415 (31%), Positives = 207/415 (49%), Gaps = 22/415 (5%) Query: 12 VDGTINLPGSKSVSNRALLLAAL----AHGKTVLTNLLDSDDVRHMLNALTALGVSYTLS 67 V T+ +PGSKS +NRAL+LAAL G + ++ L S D ML+AL LG L Sbjct: 13 VRATVTVPGSKSQTNRALVLAALAAAQGRGASTISGALRSRDTELMLDALQTLG----LR 68 Query: 68 ADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIG 127 D E+ +G GA + G AGT +R + LGS + G+ + + RPI Sbjct: 69 VDGVGSELTVSGRIEPGPGA-RVDCGLAGTVLRFVPPLAALGSVPVTFDGDQQARGRPIA 127 Query: 128 HLVDALRLGGAKITYLEQENYP-PLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPED 186 L+DALR G + + P +R G GG V +D S SSQF++ LL++A + Sbjct: 128 PLLDALRELGVAV---DGTGLPFRVRGNGSLAGGTVAIDASASSQFVSGLLLSAASFTDG 184 Query: 187 TVIRIKGD-LVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDASS 245 ++ G L S P+I +T +++ GV+I++ ++ V+ G + +E D ++ Sbjct: 185 LTVQHTGSSLPSAPHIAMTAAMLRQAGVDIDDSTPNRWQVRPGPVAAR--RWDIEPDLTN 242 Query: 246 ASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGE--LNA 303 A FL+AA + GGTV++TG R S+Q +L ++ A + D + RG + Sbjct: 243 AVAFLSAAVVSGGTVRITGWPRVSVQPADHILAILRQLNAVVIHADSSLEV-RGPTGYDG 301 Query: 304 IDMDMNHIPDAAMTIATAALFAK--GTTTLRNIYNWRVKETDRLFAMATELRKVGAEVEE 361 D+D+ + + ++A A A + L I + R ETDRL A++TE+ ++G E Sbjct: 302 FDVDLRAVGELTPSVAALAALASPGSVSRLSGIAHLRGHETDRLAALSTEINRLGGTCRE 361 Query: 362 GHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDY 416 D + IT L Y DHRMAM +++ L V + D T KT P++ Sbjct: 362 TPDGLVIT-ATPLRPGIWRAYADHRMAMAGAIIGLRVAGVEVDDIAATTKTLPEF 415 >3RMT-A nrPDB Length = 455 Score = 142 bits (359), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 126/445 (28%), Positives = 215/445 (48%), Gaps = 31/445 (6%) Query: 1 MESLTLQPIAR-VDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTA 59 ME+ T+ P A+ + GTI +PG KS+S+RA++ ALA G T + L D ++ Sbjct: 3 MENKTVIPHAKGLKGTIKVPGDKSISHRAVMFGALAKGTTTVEGFLPGADCLSTISCFQK 62 Query: 60 LGVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEP 119 LGVS + +R + G G E + L +GN+GT R + L V+ G+ Sbjct: 63 LGVSIEQAEERVTVK--GKGWDGLREPSDILDVGNSGTTTRLILGILSTLPFHSVIIGDE 120 Query: 120 RMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMT 179 + +RP+ + + L+ GA+I + N PL ++GG G +D V+S + + ++ Sbjct: 121 SIGKRPMKRVTEPLKSMGAQIDGRDHGNLTPLSIRGGQLKG-IDFHSPVASAQMKSAILL 179 Query: 180 APLAPEDTVIRIKGDLVSKPYI--DITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTY 237 A L E V++P D T +++ FGV IE ++GGQ Sbjct: 180 AGLRAEGKT------SVTEPAKTRDHTERMLEAFGVNIEKDGL-TVSIEGGQMLTGQ-HV 231 Query: 238 LVEGDASSASYFLAAAA-IKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYI-- 294 +V GD SSA++FL A A + + +T +G N + I +VL++MGAT+ ++ + Sbjct: 232 VVPGDISSAAFFLVAGAMVPHSRITLTNVGINPTRAGI--LEVLKQMGATLAMENERVQG 289 Query: 295 -------SCTRGELNAIDMDMNHIP---DAAMTIATAALFAKGTTTLRNIYNWRVKETDR 344 + L +++ + IP D IA A A G T +++ +VKET+R Sbjct: 290 GEPVADLTIETSVLQGVEIGGDIIPRLIDEIPIIAVLATQASGRTVIKDAEELKVKETNR 349 Query: 345 LFAMATELRKVGAEVEEGHDYIRITPPEKLNFA-EIATYNDHRMA-MCFSLVALSDTPVT 402 + + +EL K+GA + D + I P L ++++ DHR+ L++ PVT Sbjct: 350 IDTVVSELTKLGASIHATDDGMIIEGPTPLKGGVTVSSHGDHRIGMAMAIAALLAEKPVT 409 Query: 403 ILDPKCTAKTFPDYFEQLARISQAA 427 + + A ++P +F+ L R+ A Sbjct: 410 VEGTEAIAVSYPSFFDHLDRLKSEA 434 >1RF6-A nrPDB Length = 427 Score = 121 bits (304), Expect = 6e-28, Method: Compositional matrix adjust. Identities = 109/427 (25%), Positives = 203/427 (47%), Gaps = 27/427 (6%) Query: 9 IARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSA 68 I + G I +PG KS+S+R+++ +LA G+T + ++L +DV + LGV Sbjct: 7 IRHLHGIIRVPGDKSISHRSIIFGSLAEGETKVYDILRGEDVLSTMQVFRDLGVEIEDKD 66 Query: 69 DRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGH 128 + +G G + AL + GN+GT++R ++ L ++ + G+ + +RP+ Sbjct: 67 GVITVQGVGMAGLKAPQNALNM--GNSGTSIRLISGVLAGADFEVEMFGDDSLSKRPMDR 124 Query: 129 LVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSS-QFLTALLMTAPLAPEDT 187 + L+ G I+ + + PPLRL+G + + ++S Q +AL+ A A ++ Sbjct: 125 VTLPLKKMGVSISGQTERDLPPLRLKGTKNLRPIHYELPIASAQVKSALMFAALQAKGES 184 Query: 188 VIRIKGDLVSKPYI-DITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDASSA 246 VI + K Y + T ++++ FG + + ++ V+G Q +V GD SSA Sbjct: 185 VI------IEKEYTRNHTEDMLQQFGGHL-SVDGKKITVQGPQKLTGQ-KVVVPGDISSA 236 Query: 247 SYFLAAAAIKGGT-VKVTGIGRNSMQGDIRFADVLEKMGATI-------CWGDDYISCTR 298 +++L A I + + + +G N + I DV+ MG + + Sbjct: 237 AFWLVAGLIAPNSRLVLQNVGINETRTGI--IDVIRAMGGKLEITEIDPVAKSATLIVES 294 Query: 299 GELNAIDMDMNHIP---DAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKV 355 +L ++ IP D IA A A+G T +++ +VKETDR+ +A L + Sbjct: 295 SDLKGTEICGALIPRLIDELPIIALLATQAQGVTVIKDAEELKVKETDRIQVVADALNSM 354 Query: 356 GAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVAL--SDTPVTILDPKCTAKTF 413 GA++ D + I L+ A + T+ DHR+ M ++ AL +D V + + ++ Sbjct: 355 GADITPTADGMIIKGKSALHGARVNTFGDHRIGMMTAIAALLVADGEVELDRAEAINTSY 414 Query: 414 PDYFEQL 420 P +F+ L Sbjct: 415 PSFFDDL 421 >2GG4-A nrPDB Length = 455 Score = 118 bits (295), Expect = 6e-27, Method: Compositional matrix adjust. Identities = 126/442 (28%), Positives = 209/442 (47%), Gaps = 50/442 (11%) Query: 12 VDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRT 71 + GT+ +PG KS+S+R+ + LA G+T +T LL+ +DV + A+ A+G D Sbjct: 18 LSGTVRIPGDKSISHRSFMFGGLASGETRITGLLEGEDVINTGKAMQAMGARIRKEGDTW 77 Query: 72 RCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVD 131 + +GNGG L E L+ GNA T R + + D G+ + +RP+G +++ Sbjct: 78 IIDGVGNGGLLAPEAPLD--FGNAATGCRLTMGLVGVYDFDSTFIGDASLTKRPMGRVLN 135 Query: 132 ALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSV-SSQFLTALLMTAPLAPEDTVIR 190 LR G ++ E + P+ L+G T + + S+Q +A+L+ P T Sbjct: 136 PLREMGVQVKS-EDGDRLPVTLRGPKTPTPITYRVPMASAQVKSAVLLAGLNTPGITT-- 192 Query: 191 IKGDLVSKPYI--DITLNLMKTFG----VEIENQHYQQFVVKG-----GQSYQSPGTYLV 239 V +P + D T +++ FG VE + + ++G GQ P Sbjct: 193 -----VIEPIMTRDHTEKMLQGFGANLTVETDADGVRTIRLEGRGKLTGQVIDVP----- 242 Query: 240 EGDASSASYFLAAA-AIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATI-------CWGD 291 GD SS ++ L AA + G V + + N + + L++MGA I G+ Sbjct: 243 -GDPSSTAFPLVAALLVPGSDVTILNVLMNPTRTGLIL--TLQEMGADIEVINPRLAGGE 299 Query: 292 DY--ISCTRGELNAIDMDMNHIP---DAAMTIATAALFAKGTTTLRNIYNWRVKETDRLF 346 D + L + + + P D +A AA FA+G T + + RVKE+DRL Sbjct: 300 DVADLRVRSSTLKGVTVPEDRAPSMIDEYPILAVAAAFAEGATVMNGLEELRVKESDRLS 359 Query: 347 AMATELRKVGAEVEEGHD--YIRITPPEK----LNFAEIATYNDHRMAMCFSLVAL-SDT 399 A+A L+ G + +EG +R P K + A +AT+ DHR+AM F ++ L S+ Sbjct: 360 AVANGLKLNGVDCDEGETSLVVRGRPDGKGLGNASGAAVATHLDHRIAMSFLVMGLVSEN 419 Query: 400 PVTILDPKCTAKTFPDYFEQLA 421 PVT+ D A +FP++ + +A Sbjct: 420 PVTVDDATMIATSFPEFMDLMA 441 >5U4H-A nrPDB Length = 421 Score = 75.5 bits (184), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 106/405 (26%), Positives = 166/405 (40%), Gaps = 34/405 (8%) Query: 11 RVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADR 70 +++G + + G+K+ + L LA LTN+ + DV ++ + LGV+ + D Sbjct: 14 KLEGEVRISGAKNAALPLLAAMILADSPITLTNVPNLKDVNTLVKLIGGLGVTISYENDT 73 Query: 71 TRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALC-LGSNDIVLTGEPRMKERPIGHL 129 + + L + A + ++ L L G+ + L G + RP+ Sbjct: 74 VKADT----STLDNQFAPYELVKTMRASILVLGPLLARYGNAKVSLPGGCAIGSRPVDQH 129 Query: 130 VDALRLGGAKITYLEQEN-YPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTV 188 + AL GA ++E EN Y + G GG V D V+ +LM A LA T Sbjct: 130 LKALEALGA---HIEVENGYVHATVDGRLKGGEVVFD-MVTVGGTENILMAAALADGVTT 185 Query: 189 IRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDASSASY 248 IR + +P I ++ G +IE VV G +S Y V D Sbjct: 186 IR---NAAREPEITDLAQMLIKMGAKIEGLDTDTLVVTGVESLHGC-EYAVVADRIETGS 241 Query: 249 FLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGELNAIDMDM 308 +LAAAAI GG VK T + ++ + D E+MGA + GDD+I + Sbjct: 242 YLAAAAITGGRVKTTHTDPSLLEAVL---DKFEEMGAEVTRGDDWIELDMLGKRPKAVSF 298 Query: 309 NHIP------DAAMTIATAALFAKGTTTL-RNIYNWRVKETDRLFAMATELRKVGAEVE- 360 +P D I +G T+ I+ R F EL ++GA ++ Sbjct: 299 RTLPHPEFPTDMQAQIMAVNAIGRGFATISETIFENR-------FMHVPELSRMGANIQV 351 Query: 361 EGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILD 405 EGHD + +T EKL A + D R + L AL T++D Sbjct: 352 EGHDAV-VTGVEKLQAAPVMA-TDLRASFSLVLAALVAEGDTLID 394 >2Z2C-A nrPDB Length = 423 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 104/423 (24%), Positives = 166/423 (39%), Gaps = 51/423 (12%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 M+ +Q ++ G + + G+K+ + L A LA + N+ DV + L+ L Sbjct: 1 MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQL 60 Query: 61 GVSYTLSADRTRCEIIGNGGPLHAEGA-LELF---------LGNAGTAMRPLAAALCLGS 110 G + G +H + + +F + + A+ PL A G Sbjct: 61 GAK------------VERDGSVHIDARDVNVFCAPYDLVKTMRASIWALGPLVARF--GQ 106 Query: 111 NDIVLTGEPRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSS 170 + L G + RP+ + L GA I +E Y + G G ++ +D VS Sbjct: 107 GQVSLPGGCTIGARPVDLHISGLEQLGATIKL--EEGYVKASVDGRLKGAHIVMD-KVSV 163 Query: 171 QFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQS 230 ++ A LA T+I + +P I T N + T G +I Q + V++G + Sbjct: 164 GATVTIMCAATLAEGTTIIE---NAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVER 220 Query: 231 YQSPGTYLVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKM---GATI 287 G Y V D FL AAAI G + I RN+ Q D A VL K+ GA I Sbjct: 221 LGG-GVYRVLPDRIETGTFLVAAAISRGKI----ICRNA-QPDTLDA-VLAKLRDAGADI 273 Query: 288 CWGDDYISCTRGELNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIY---NWRVKET-- 342 G+D+IS +++ P A A F TL N+ + ET Sbjct: 274 EVGEDWISLDMHGKRPKAVNVRTAPHPAFPTDMQAQF-----TLLNLVAEGTGFITETVF 328 Query: 343 DRLFAMATELRKVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVT 402 + F EL ++GA E + + EKL+ A++ D R + L T Sbjct: 329 ENRFMHVPELSRMGAHAEIESNTVICHGVEKLSGAQVMA-TDLRASASLVLAGCIAEGTT 387 Query: 403 ILD 405 ++D Sbjct: 388 VVD 390 >6CN1-A nrPDB Length = 424 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 102/423 (24%), Positives = 166/423 (39%), Gaps = 48/423 (11%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 M+ L + AR+DG I + G+K+ + L LA G + NL D+ M+ + Sbjct: 4 MDKLIITGGARLDGEIRISGAKNAALPILAATLLADGPVTVGNLPHLHDITTMIELFGRM 63 Query: 61 GVSYTLSAD-------RTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDI 113 G+ + RT ++ + A L LG P+ A G ++ Sbjct: 64 GIEPVIDEKLSVEIDPRTIKTLVAPYELVKTMRASILVLG-------PMVAR--FGEAEV 114 Query: 114 VLTGEPRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFL 173 L G + RP+ + L GAKI +E +GG G + D +VS Sbjct: 115 ALPGGCAIGSRPVDLHIRGLEAMGAKIE-VEGGYIKAKAPEGGLRGAHFFFD-TVSVTGT 172 Query: 174 TALLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQS 233 ++M A LA +V++ + +P + N + G I+ + G + S Sbjct: 173 ENIMMAAALAKGRSVLQ---NAAREPEVVDLANFINAMGGNIQGAGTDTITIDGVERLDS 229 Query: 234 PGTYLVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKM---GATICWG 290 Y V D +L AAA+ GG VKV ++ VLEK+ GA I G Sbjct: 230 -ANYRVMPDRIETGTYLVAAAVTGGRVKVKDTDPTILEA------VLEKLKEAGADINTG 282 Query: 291 DDYISCTRGELNAIDMDMNHIPDAAMTIATAALF------AKGT-TTLRNIYNWRVKETD 343 +D+I +++ P A A F A+GT + I+ R Sbjct: 283 EDWIELDMHGKRPKAVNLRTAPYPAFPTDMQAQFISLNAIAEGTGAVIETIFENR----- 337 Query: 344 RLFAMATELRKVGAEVE-EGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVT 402 F E+ ++GA+++ EG+ I +T + L A + D R + L AL T Sbjct: 338 --FMHVYEMHRMGAQIQVEGNTAI-VTGVKALKGAPVMA-TDLRASASLVLSALVAEGDT 393 Query: 403 ILD 405 ++D Sbjct: 394 LID 396 >2RL1-A nrPDB Length = 424 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 72/297 (24%), Positives = 120/297 (40%), Gaps = 16/297 (5%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 M+ + +R+ G++N+ G+K+ + L A LA LTN+ + D+ L L L Sbjct: 1 MDKFRVYGQSRLSGSVNISGAKNAALPILFAAILATEPVKLTNVPELKDIETTLKILRQL 60 Query: 61 GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGT--AMRPLAAALCLGSNDIVLTGE 118 GV + D T ++ H EL + A+ PL A G + L G Sbjct: 61 GV--VVDRDATGAVLLDASNINHFTAPYELVKTMRASIWALAPLVARFHQGQ--VSLPGG 116 Query: 119 PRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLM 178 + RP+ + L GA I +E Y ++ G + ++ VS +++M Sbjct: 117 CSIGARPVDLHISGLEKLGADIVL--EEGYVKAQVSDRLVGTRIVIE-KVSVGATLSIMM 173 Query: 179 TAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYL 238 A LA TVI + +P I T + + G +I ++G + + Sbjct: 174 AATLAKGTTVIE---NAAREPEIVDTADFLNKMGAKITGAGSAHITIEGVERLTGCEHSV 230 Query: 239 VEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYIS 295 V D FL AAAI GG V +++ I D L + GA + ++ I+ Sbjct: 231 VP-DRIETGTFLIAAAISGGCVVCQNTKADTLDAVI---DKLREAGAQVDVTENSIT 283 >3VCY-A nrPDB Length = 430 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 70/277 (25%), Positives = 112/277 (40%), Gaps = 27/277 (9%) Query: 98 AMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGF 157 A+ PL A G + L G + RP+ + L GA I +E Y + G Sbjct: 97 ALGPLVARF--GKGQVSLPGGCAIGARPVDLHIHGLEQLGATIKL--EEGYVKAEVDGRL 152 Query: 158 TGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIEN 217 G ++ +D VS ++ A LA TV+ + +P I T N + G ++ Sbjct: 153 KGAHIVMD-KVSVGATITVMCAATLAEGTTVLE---NAAREPEIVDTANFLNAIGAKVSG 208 Query: 218 QHYQQFVVKGGQSYQSPGTYLVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFA 277 ++G + G + V D FL AAA+ GG + + ++ + Sbjct: 209 MGTDTITIEGVERLGG-GYHEVVADRIETGTFLVAAAVSGGKIVCKNTKAHLLEAVLAK- 266 Query: 278 DVLEKMGATICWGDDYISC--TRGELNAIDMDMNHIP----DAAMTIATAALFAKGTTTL 331 LE+ GA + GDD+IS T EL A+++ P D + AKG+ + Sbjct: 267 --LEEAGADVQTGDDWISLDMTGRELKAVNIRTAPHPAFPTDMQAQFTLLNMMAKGSGII 324 Query: 332 -RNIYNWRVKETDRLFAMATELRKVGAEVE-EGHDYI 366 I+ R F EL+++GA E EG+ I Sbjct: 325 TETIFENR-------FMHIPELQRMGAHAEIEGNTAI 354 >5BQ2-A nrPDB Length = 429 Score = 42.7 bits (99), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 70/296 (23%), Positives = 120/296 (40%), Gaps = 13/296 (4%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 M+ L + R+DG I + G+K+ + L LA + NL D+ M+ + Sbjct: 9 MDKLIITGGNRLDGEIRISGAKNSALPILAATLLADTPVTVCNLPHLHDITTMIELFGRM 68 Query: 61 GVSYTLSADRTRCEIIGNG-GPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEP 119 GV + ++ E+ + L A L + + + P+ A G ++ L G Sbjct: 69 GVQPIID-EKLNVEVDASSIKTLVAPYELVKTMRASILVLGPMLAR--FGEAEVALPGGC 125 Query: 120 RMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMT 179 + RP+ + L GA+I +E GG GG+ D +VS L+M Sbjct: 126 AIGSRPVDLHIRGLEAMGAQIE-VEGGYIKAKAPAGGLRGGHFFFD-TVSVTGTENLMMA 183 Query: 180 APLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLV 239 A LA TV++ + +P + N + G ++ V++G + Y V Sbjct: 184 AALANGRTVLQ---NAAREPEVVDLANCLNAMGANVQGAGSDTIVIEGVKRLGG-ARYDV 239 Query: 240 EGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYIS 295 D +L AAA GG VK+ ++ ++ LE+ GA I G ++I Sbjct: 240 LPDRIETGTYLVAAAATGGRVKLKDTDPTILEAVLQK---LEEAGAHISTGSNWIE 292 >3R38-A nrPDB Length = 454 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 85/396 (21%), Positives = 158/396 (39%), Gaps = 48/396 (12%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALA-HGKTVLTNLLDSDDVRHMLNALTA 59 ME + ++ +++G++ + G+K+ + LA G +VL N+ + DV + L Sbjct: 25 MEKIIVRGGKQLNGSVKMEGAKNAVLPVIAATLLASKGTSVLKNVPNLSDVFTINEVLKY 84 Query: 60 LGVSYTLSADRTRCEIIGNGGPLHAEGALELF--LGNAGTAMRPLAAALCLGSNDIVLTG 117 L + D + G + ++ E + + M PL A GS + L G Sbjct: 85 LNADVSFVNDEVTVDATGE---ITSDAPFEYVRKMRASIVVMGPLLART--GSARVALPG 139 Query: 118 EPRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVD--VDGSVSSQFLTA 175 + RP+ + GA + +++ G+ + V V F + Sbjct: 140 GCAIGSRPVDLHLKGFEAMGAVV-----------KIENGYIEATAEKLVGAKVYLDFPSV 188 Query: 176 -----LLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQS 230 ++M A LA TVI ++ +P I N + G + + ++G + Sbjct: 189 GATQNIMMAATLAEGTTVIE---NVAREPEIVDLANFLNQMGARVIGAGTEVIRIEGVKE 245 Query: 231 YQSPGTYLVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWG 290 + ++ D A F+ AAAI GG V + + I LE+MG I Sbjct: 246 LTATEHSIIP-DRIEAGTFMIAAAITGGNVLIEDAVPEHISSLIA---KLEEMGVQIIEE 301 Query: 291 DDYISCT-RGELNAIDMDMNHIP----DAAMTIATAALFAKGTTTL-RNIYNWRVKETDR 344 ++ I +L A+D+ P D + + ++GT+ + ++ R Sbjct: 302 ENGIRVIGPDKLKAVDVKTMPHPGFPTDMQSQMMVIQMLSEGTSIMTETVFENR------ 355 Query: 345 LFAMATELRKVGAEVE-EGHDYIRITPPEKLNFAEI 379 F E+R++ A+++ EGH I I+ P KL AE+ Sbjct: 356 -FMHVEEMRRMNADMKIEGHSVI-ISGPAKLQGAEV 389 Score = 31.2 bits (69), Expect = 0.86, Method: Compositional matrix adjust. Identities = 43/191 (22%), Positives = 79/191 (41%), Gaps = 21/191 (10%) Query: 197 SKPYIDITLNLMKTFG--VEIENQHYQQFVVKGGQSYQSPGTYLVEGDASSASYFLAAAA 254 S+P +D+ L + G V+IEN + + + YL + + AA Sbjct: 145 SRP-VDLHLKGFEAMGAVVKIENGYIEAT----AEKLVGAKVYLDFPSVGATQNIMMAAT 199 Query: 255 IKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRG--ELNAIDMDMNHIP 312 + GT + + R D+ A+ L +MGA + + G EL A + + IP Sbjct: 200 LAEGTTVIENVAREPEIVDL--ANFLNQMGARVIGAGTEVIRIEGVKELTATEHSI--IP 255 Query: 313 D--AAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVEEGHDYIRITP 370 D A T AA G + + + + ++ +L ++G ++ E + IR+ Sbjct: 256 DRIEAGTFMIAAAITGGNVLIEDAV------PEHISSLIAKLEEMGVQIIEEENGIRVIG 309 Query: 371 PEKLNFAEIAT 381 P+KL ++ T Sbjct: 310 PDKLKAVDVKT 320 >3SG1-A nrPDB Length = 458 Score = 38.5 bits (88), Expect = 0.006, Method: Compositional matrix adjust. Identities = 93/433 (21%), Positives = 168/433 (38%), Gaps = 37/433 (8%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAH-GKTVLTNLLDSDDVRHMLNALTA 59 ME + ++ R++GT+ + G+K+ + A LA GK VL+ + DV + L Sbjct: 25 MEKIIVRGGKRLNGTVRVEGAKNAVLPIIAAALLASDGKNVLSEVPVLSDVYTINEVLRH 84 Query: 60 LGVSYTLSADRTRCEIIGNGGPLHAEGALELF--LGNAGTAMRPLAAALCLGSNDIVLTG 117 L ++ I L+ E E + + M PL A G I L G Sbjct: 85 LNAEVVFENNQV---TIDASKELNIEAPFEYVRKMRASVQVMGPLLAR--NGRARIALPG 139 Query: 118 EPRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALL 177 + RPI + GAK+ + ++G G + +D S T + Sbjct: 140 GCAIGSRPIDQHLKGFEAMGAKVQV--GNGFVEAYVEGELKGAKIYLD--FPSVGATENI 195 Query: 178 MTAP-LAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGT 236 M+A LA T++ + +P I N + G ++ ++G Sbjct: 196 MSAATLAKGTTILE---NAAKEPEIVDLANFLNAMGAKVRGAGTGTIRIEGVDKLYGANH 252 Query: 237 YLVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIR-FADVLEKMGATICWGDDYIS 295 ++ D A F+ AAAI GG + + N++ +R +E+MG I ++ + Sbjct: 253 SIIP-DRIEAGTFMVAAAITGGDILI----ENAVPEHLRSITAKMEEMGVKIIEENEGVR 307 Query: 296 CT-RGELNAIDMDMNHIP----DAAMTIATAALFAKGTTTL-RNIYNWRVKETDRLFAMA 349 +L A+D+ P D + L A GT+ + ++ R F Sbjct: 308 VIGPDKLKAVDIKTMPHPGFPTDMQSQMMALLLQADGTSMITETVFENR-------FMHV 360 Query: 350 TELRKVGAEVE-EGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKC 408 E R++ A+++ EG I + P L AE+ + A +S+ + + K Sbjct: 361 EEFRRMNADIKIEGRSVI-MNGPNSLQGAEVGATDLRAAAALILAGLVSEGYTRVTELKH 419 Query: 409 TAKTFPDYFEQLA 421 + + D+ ++LA Sbjct: 420 LDRGYVDFHKKLA 432 >2YVW-A nrPDB Length = 425 Score = 37.7 bits (86), Expect = 0.011, Method: Compositional matrix adjust. Identities = 78/361 (21%), Positives = 144/361 (39%), Gaps = 47/361 (13%) Query: 14 GTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRC 73 G + + G+K+ + + L +TN+ D DVR+ L L LG Sbjct: 23 GKVKISGAKNAALPIMFATILTEEPCTITNVPDLLDVRNTLLLLRELGAE---------L 73 Query: 74 EIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCL-------GSNDIVLTGEPRMKERPI 126 E + N + ++ F+ N R A+ L L G + L G + RPI Sbjct: 74 EFLNN--TVFINPSINSFITNQEIIRRMRASVLSLGPLLGRFGRAVVGLPGGCSIGARPI 131 Query: 127 GHLVDALRLGGAKITYLEQENYPPLRLQG--GFTGGNVDVDGSVSSQFLTALLMTAPLAP 184 + + GA + E Y L+ + F V V G+ + ALL A + P Sbjct: 132 DQHLKFFKEAGADVEVREGYVYVNLKEKRRVHFKFDLVTVTGTEN-----ALLYLASV-P 185 Query: 185 EDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDAS 244 E++++ ++ +P + + ++K G ++ + + VKG ++ + T+ V D Sbjct: 186 EESILE---NIALEPEVMDLIEVLKKMGAHVKVEGRSAY-VKGSENLKG-FTHSVIPDRI 240 Query: 245 SASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGE-LNA 303 A F+ A + G + + N ++ + + L+ +G + + + R E L A Sbjct: 241 EAGTFMVGAVLTDGEILLENARINHLRAVV---EKLKLIGGEVVEENGNLRVFRKESLRA 297 Query: 304 IDMDMNHIP----DAAMTIATAALFAKGTTTLR-NIYNWRVKETDRLFAMATELRKVGAE 358 D++ P D AKG + ++ NI+ R F A EL ++GA Sbjct: 298 CDIETQVYPGFPTDMQAQFMALLSVAKGKSRIKENIFEHR-------FHHAQELNRLGAN 350 Query: 359 V 359 + Sbjct: 351 I 351 >5WI5-A nrPDB Length = 430 Score = 37.4 bits (85), Expect = 0.012, Method: Compositional matrix adjust. Identities = 98/429 (22%), Positives = 166/429 (38%), Gaps = 43/429 (10%) Query: 11 RVDGTINLPGSKSVSNRALLLAALA-HGKTVLTNLLDSDDVRHMLNALTALGVSYTLSAD 69 R+ G++ + G+K+ L LA GKTVL N+ DV M + L + Sbjct: 15 RLVGSVTIEGAKNAVLPLLAATILASEGKTVLQNVPILSDVFIMNQVVGGLNAKVDFDEE 74 Query: 70 RTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALC-LGSNDIVLTGEPRMKERPIGH 128 ++ G E A ++ ++ L L +G + + G + RPI Sbjct: 75 AHLVKVDATGDI--TEEAPYKYVSKMRASIVVLGPILARVGHAKVSMPGGCTIGSRPIDL 132 Query: 129 LVDALRLGGAKIT----YLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAP 184 + L G KI+ Y+E + RL G + G+ + L+M A LA Sbjct: 133 HLKGLEAMGVKISQTAGYIEAKAE---RLHGAHIYMDFPSVGATQN-----LMMAATLAD 184 Query: 185 EDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDAS 244 TVI + +P I L+ G +++ + + G + T+ V D Sbjct: 185 GVTVIE---NAAREPEIVDLAILLNEMGAKVKGAGTETITITGVEKLHGT-THNVVQDRI 240 Query: 245 SASYFLAAAAIKGGTVKVTGIGRNSMQGDIR--FADVLEKMGATICWGDDYISCTRGELN 302 A F+ AAA+ GG V + R+++ R A +LE MG + D+ I N Sbjct: 241 EAGTFMVAAAMTGGDVLI----RDAVWEHNRPLIAKLLE-MGVEVIEEDEGIRVRSQLEN 295 Query: 303 AIDMDMNHIPDAAMTIATAALF------AKGTTTL-RNIYNWRVKETDRLFAMATELRKV 355 + + +P A F AKG +T+ ++ R F E+R++ Sbjct: 296 LKAVHVKTLPHPGFPTDMQAQFTALMTVAKGESTMVETVFENR-------FQHLEEMRRM 348 Query: 356 GAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTA-KTFP 414 G E D RI + L AE+ + D R + L L T++ + + Sbjct: 349 GLHSEIIRDTARIVGGQPLQGAEVLS-TDLRASAALILTGLVAQGETVVGKLVHLDRGYY 407 Query: 415 DYFEQLARI 423 + E+LA++ Sbjct: 408 GFHEKLAQL 416 >5Z74-B nrPDB Length = 457 Score = 33.9 bits (76), Expect = 0.16, Method: Compositional matrix adjust. Identities = 35/128 (27%), Positives = 56/128 (43%), Gaps = 8/128 (6%) Query: 140 ITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMT--APLAPEDTVIRIKGDLVS 197 I Y E + + P + GG+ GNV + F LM + LA E+ I L+ Sbjct: 276 IPYYELDKWLPKK--GGYLAGNVGPSQLDTRFFALGNLMAIISDLATEEQSQAIM-TLIE 332 Query: 198 KPYIDITLNL-MKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDASSASYFLAAAAIK 256 + D+ ++ MK +EN+ Y+ +V G P +Y G + LAAA++K Sbjct: 333 DRWEDLVGDMPMKICYPALENEEYR--IVTGCDPKNIPWSYHNAGSWPVLMWMLAAASVK 390 Query: 257 GGTVKVTG 264 G + G Sbjct: 391 AGKPYIAG 398 >1A8Q-A nrPDB Length = 274 Score = 30.8 bits (68), Expect = 1.2, Method: Compositional matrix adjust. Identities = 26/106 (24%), Positives = 41/106 (38%), Gaps = 1/106 (0%) Query: 174 TALLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQS 233 T L +A L + IK D D + +K GV E + + +G S Sbjct: 109 TGRLRSAVLLSAIPPVMIKSDKNPDGVPDEVFDALKN-GVLTERSQFWKDTAEGFFSANR 167 Query: 234 PGTYLVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADV 279 PG + +G+ + Y A I+GG V G D++ D+ Sbjct: 168 PGNKVTQGNKDAFWYMAMAQTIEGGVRCVDAFGYTDFTEDLKKFDI 213 >3KUK-A nrPDB Length = 309 Score = 29.6 bits (65), Expect = 2.8, Method: Compositional matrix adjust. Identities = 18/67 (26%), Positives = 33/67 (49%) Query: 134 RLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKG 193 RL GA +Y E++ LR N++++ SV + A + A + + R++G Sbjct: 218 RLDGALCSYTEKDKQDYLRAAYAAGIRNIEMEASVFAAMCNACGLRAAVVCVTLLNRLEG 277 Query: 194 DLVSKPY 200 D +S P+ Sbjct: 278 DQISSPH 284 >3TQI-A nrPDB Length = 527 Score = 28.9 bits (63), Expect = 3.9, Method: Compositional matrix adjust. Identities = 23/81 (28%), Positives = 34/81 (41%), Gaps = 1/81 (1%) Query: 176 LLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPG 235 L+ P IRI G+ VS YI+I F E++ Y V + + Sbjct: 399 LIYRHPFPGPGLAIRILGE-VSAEYINILKQADAIFIEELKKSDYYHQVSQAFAVFMPLK 457 Query: 236 TYLVEGDASSASYFLAAAAIK 256 + V+GDA Y +A A+K Sbjct: 458 SVGVKGDARHYGYIIALRAVK 478 >5UJS-A nrPDB Length = 442 Score = 28.9 bits (63), Expect = 3.9, Method: Compositional matrix adjust. Identities = 82/396 (20%), Positives = 156/396 (39%), Gaps = 48/396 (12%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 M L ++ + G + + G+K+ + ++ + LA + + N+ + D++ +++ L L Sbjct: 25 MTYLEIEGTNHLSGNVTISGAKNAALPLIVSSILAKNEVKINNVPNVADIKTLISLLENL 84 Query: 61 GVSYTLSAD------RTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIV 114 G + T + I + A L LG PL A G ++ Sbjct: 85 GAKVNFQNNSALLNTNTLNQTIAKYDIVRKMRASILTLG-------PLLAR--FGHCEVS 135 Query: 115 LTGEPRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLT 174 L G + +RPI + AL GA I ++ Y + G G + D ++ Sbjct: 136 LPGGCAIGQRPIDLHLLALEKMGANIQI--KQGY--VVASGNLKGNEILFD-KITVTGSE 190 Query: 175 ALLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSP 234 ++M A LA T + ++ +P + ++K G+EI+ + + Y S Sbjct: 191 NIIMAAALAKGKTKLL---NVAKEPEVVQLCEVLKDAGLEIKGIGTDELEI-----YGSD 242 Query: 235 GTYL------VEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATIC 288 G L V D A +L A AI + + + + + L +MG Sbjct: 243 GELLEFKEFSVIPDRIEAGTYLCAGAITNSKITLDKVNATHLSAVLA---KLHQMGFETL 299 Query: 289 WGDDYISCTRG-ELNAIDMDMNHIP----DAAMTIATAALFAKGTTTLRNIYNWRVKETD 343 +D I+ E+ +++ + P D AL A GT+ I + R+ E Sbjct: 300 ITEDSITLLPAKEIKPVEIMTSEYPGFPTDMQAQFMALALKANGTS----IIDERLFENR 355 Query: 344 RLFAMATELRKVGAEVEEGHDYIRITPPEKLNFAEI 379 F +EL ++GA+++ I ++LN A++ Sbjct: 356 --FMHVSELLRMGADIKLNGHIATIVGGKELNAADV 389 >3KQA-A nrPDB Length = 419 Score = 28.9 bits (63), Expect = 5.1, Method: Compositional matrix adjust. Identities = 17/52 (32%), Positives = 26/52 (50%), Gaps = 6/52 (11%) Query: 317 TIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVEEGHDYIRI 368 T AA + G RN + D L A+ +LR+ GA++E G D+I + Sbjct: 237 TFLVAAAISGGKIVCRN------AQPDTLDAVLAKLREAGADIETGEDWISL 282 >3EUF-A nrPDB Length = 328 Score = 28.5 bits (62), Expect = 5.5, Method: Compositional matrix adjust. Identities = 18/68 (26%), Positives = 35/68 (51%), Gaps = 4/68 (5%) Query: 134 RLGGAKITYLEQENYPPLRLQGGFTGG--NVDVDGSVSSQFLTALLMTAPLAPEDTVIRI 191 RL GA +Y E++ L+ + G N++++ SV + +A + A + + R+ Sbjct: 237 RLDGALCSYTEKDKQA--YLEAAYAAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRL 294 Query: 192 KGDLVSKP 199 +GD +S P Sbjct: 295 EGDQISSP 302 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3FJZ-A nrPDB 576 e-165 3NVS-A nrPDB 543 e-155 5XWB-A nrPDB 530 e-151 3SLH-A nrPDB 397 e-111 3RMT-A nrPDB 394 e-110 1RF6-A nrPDB 386 e-107 5BS5-A nrPDB 386 e-107 6CN1-A nrPDB 345 3e-95 2GG4-A nrPDB 344 6e-95 2Z2C-A nrPDB 342 1e-94 5BQ2-A nrPDB 341 4e-94 5U4H-A nrPDB 332 2e-91 2RL1-A nrPDB 329 1e-90 3VCY-A nrPDB 318 2e-87 2O0B-A nrPDB 315 2e-86 3TI2-A nrPDB 274 5e-74 1P88-A nrPDB 272 2e-73 Sequences not found previously or not previously below threshold: 3KQA-A nrPDB 343 8e-95 4R7U-A nrPDB 309 1e-84 5WI5-A nrPDB 243 1e-64 3SG1-A nrPDB 235 4e-62 3R38-A nrPDB 226 2e-59 2YVW-A nrPDB 219 3e-57 5UJS-A nrPDB 213 1e-55 3ZH3-A nrPDB 205 3e-53 4FQD-A nrPDB 113 2e-25 3T7C-A nrPDB 32 0.72 5FAX-A nrPDB 31 0.80 3MK7-B nrPDB 31 0.84 5W1J-A nrPDB 31 0.91 5IDU-A nrPDB 30 1.3 2RF1-A nrPDB 30 1.4 3U0A-A nrPDB 29 3.1 3IAW-A nrPDB 29 4.2 3QS3-A nrPDB 29 4.3 3QS2-A nrPDB 29 5.5 1J7H-A nrPDB 29 6.0 5XNX-A nrPDB 28 7.5 1WMD-A nrPDB 28 9.7 >3FJZ-A nrPDB Length = 427 Score = 576 bits (1485), Expect = e-165, Method: Composition-based stats. Identities = 426/427 (99%), Positives = 426/427 (99%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL Sbjct: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 Query: 61 GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPR 120 GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAG AMRPLAAALCLGSNDIVLTGEPR Sbjct: 61 GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGIAMRPLAAALCLGSNDIVLTGEPR 120 Query: 121 MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTA 180 MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTA Sbjct: 121 MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTA 180 Query: 181 PLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE 240 PLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE Sbjct: 181 PLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE 240 Query: 241 GDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGE 300 GDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGE Sbjct: 241 GDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGE 300 Query: 301 LNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVE 360 LNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVE Sbjct: 301 LNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVE 360 Query: 361 EGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQL 420 EGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQL Sbjct: 361 EGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQL 420 Query: 421 ARISQAA 427 ARISQAA Sbjct: 421 ARISQAA 427 >3NVS-A nrPDB Length = 450 Score = 543 bits (1400), Expect = e-155, Method: Composition-based stats. Identities = 321/426 (75%), Positives = 359/426 (84%), Gaps = 1/426 (0%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 MESLTLQPI + G +NLPGSKSVSNRALLLAALA G T LTNLLDSDD+RHMLNALT L Sbjct: 25 MESLTLQPIELISGEVNLPGSKSVSNRALLLAALASGTTRLTNLLDSDDIRHMLNALTKL 84 Query: 61 GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPR 120 GV+Y LSAD+T CE+ G G H LELFLGNAGTAMRPLAAALCLG D VLTGEPR Sbjct: 85 GVNYRLSADKTTCEVEGLGQAFHTTQPLELFLGNAGTAMRPLAAALCLGQGDYVLTGEPR 144 Query: 121 MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQG-GFTGGNVDVDGSVSSQFLTALLMT 179 MKERPIGHLVDALR GA+I YLEQEN+PPLR+QG G G V +DGS+SSQFLTA LM+ Sbjct: 145 MKERPIGHLVDALRQAGAQIEYLEQENFPPLRIQGTGLQAGTVTIDGSISSQFLTAFLMS 204 Query: 180 APLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLV 239 APLA I+I G+LVSKPYIDITL++M+ FGV++ N YQ+FV+ GQSY SPG +LV Sbjct: 205 APLAQGKVTIKIVGELVSKPYIDITLHIMEQFGVQVINHDYQEFVIPAGQSYVSPGQFLV 264 Query: 240 EGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRG 299 EGDASSASYFLAAAAIKGG VKVTGIG+NS+QGDI+FAD LEKMGA I WGDDY+ RG Sbjct: 265 EGDASSASYFLAAAAIKGGEVKVTGIGKNSIQGDIQFADALEKMGAQIEWGDDYVIARRG 324 Query: 300 ELNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEV 359 ELNA+D+D NHIPDAAMTIAT ALFAKGTT +RN+YNWRVKETDRL AMATELRKVGA V Sbjct: 325 ELNAVDLDFNHIPDAAMTIATTALFAKGTTAIRNVYNWRVKETDRLAAMATELRKVGATV 384 Query: 360 EEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQ 419 EEG D+I ITPP KL A I TY+DHRMAMCFSLVALSDTPVTI DPKCT+KTFPDYF++ Sbjct: 385 EEGEDFIVITPPTKLIHAAIDTYDDHRMAMCFSLVALSDTPVTINDPKCTSKTFPDYFDK 444 Query: 420 LARISQ 425 A++S+ Sbjct: 445 FAQLSR 450 >5XWB-A nrPDB Length = 446 Score = 530 bits (1366), Expect = e-151, Method: Composition-based stats. Identities = 291/425 (68%), Positives = 339/425 (79%), Gaps = 1/425 (0%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 ME LTL PI +++G I LPGSKS+SNRALL+AALA+G T +TNLL SDD+ HMLNAL +L Sbjct: 21 MEQLTLNPIGKINGEIFLPGSKSLSNRALLIAALANGVTKITNLLVSDDINHMLNALKSL 80 Query: 61 GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPR 120 G+ YTLS T C +IGNGG +A+ LEL+LGNAGTAMRPL AAL + +LTGEPR Sbjct: 81 GIEYTLSDCGTECTVIGNGGFFNAKKPLELYLGNAGTAMRPLCAALAASEGEFILTGEPR 140 Query: 121 MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQG-GFTGGNVDVDGSVSSQFLTALLMT 179 MKERPIGHLVDAL A I YLE ++YPP++++G TG V +DGS+SSQFLTA+LM Sbjct: 141 MKERPIGHLVDALAQLDADIEYLENKDYPPVKIKGKALTGNTVTIDGSISSQFLTAILMI 200 Query: 180 APLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLV 239 APL +T I I G+LVSKPYIDITL++M+ F V ++N Y+ F+V G QSYQ+ Y+V Sbjct: 201 APLLETNTTIEIDGELVSKPYIDITLDIMRRFNVSVQNNDYKSFIVNGKQSYQALDKYMV 260 Query: 240 EGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRG 299 EGDASSASYFLAA AIKGG V V GIG+ S+QGD FADVLEKMGA I W D+ I+ Sbjct: 261 EGDASSASYFLAAGAIKGGEVTVHGIGKLSVQGDKHFADVLEKMGAEIHWKDESITVIGK 320 Query: 300 ELNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEV 359 L A+DMDMNHIPDAAMTIAT ALFA GTTT+RNIYNWRVKETDRL AMATELRKVGAEV Sbjct: 321 PLTAVDMDMNHIPDAAMTIATTALFATGTTTIRNIYNWRVKETDRLNAMATELRKVGAEV 380 Query: 360 EEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYFEQ 419 EG DYI ITPP+ L AEI TYNDHR+AMCFSLVALSDTPVTI DPKCTAKTFPDYF++ Sbjct: 381 VEGKDYISITPPKSLKHAEIDTYNDHRVAMCFSLVALSDTPVTINDPKCTAKTFPDYFDK 440 Query: 420 LARIS 424 LA++S Sbjct: 441 LAQVS 445 >3SLH-A nrPDB Length = 441 Score = 397 bits (1019), Expect = e-111, Method: Composition-based stats. Identities = 134/438 (30%), Positives = 208/438 (47%), Gaps = 28/438 (6%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 M+ T+ P + G I +PG KS+S+RA+LLAA+A G+T + L D M++AL + Sbjct: 4 MDYQTI-PSQGLSGEICVPGDKSISHRAVLLAAIAEGQTQVDGFLMGADNLAMVSALQQM 62 Query: 61 GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPR 120 G S + D + G G L GN+GTA+R L+ L + VLTG+ Sbjct: 63 GASIQVIEDENILVVEGVGMTGLQAPPEALDCGNSGTAIRLLSGLLAGQPFNTVLTGDSS 122 Query: 121 MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSV-SSQFLTALLMT 179 ++ RP+ ++D L L GAKI N PPL++ G + + S+Q + LL+ Sbjct: 123 LQRRPMKRIIDPLTLMGAKIDST--GNVPPLKIYGNPRLTGIHYQLPMASAQVKSCLLLA 180 Query: 180 APLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLV 239 A T I P D T L+K F ++ + Q V GG ++ + Sbjct: 181 GLYARGKTCIT-----EPAPSRDHTERLLKHFHYTLQ-KDKQSICVSGGGKLKA-NDISI 233 Query: 240 EGDASSASYFLAAAAI-KGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWG-------- 290 GD SSA++F+ AA I G +++ +G N + + ++L+ MGA I Sbjct: 234 PGDISSAAFFIVAATITPGSAIRLCRVGVNPTR--LGVINLLKMMGADIEVTHYTEKNEE 291 Query: 291 -DDYISCTRGELNAIDMDMNHIP---DAAMTIATAALFAKGTTTLRNIYNWRVKETDRLF 346 I+ L ID+ + +P D + AA A+G T LR+ RVKETDR+ Sbjct: 292 PTADITVRHARLKGIDIPPDQVPLTIDEFPVLLIAAAVAQGKTVLRDAAELRVKETDRIA 351 Query: 347 AMATELRKVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVA-LSDTPVTILD 405 AM L+K+G E D + I L E+ +Y+DHR+AM F++ L+ PV I + Sbjct: 352 AMVDGLQKLGIAAESLPDGVIIQG-GTLEGGEVNSYDDHRIAMAFAVAGTLAKGPVRIRN 410 Query: 406 PKCTAKTFPDYFEQLARI 423 +FP++ E + Sbjct: 411 CDNVKTSFPNFVELANEV 428 >3RMT-A nrPDB Length = 455 Score = 394 bits (1012), Expect = e-110, Method: Composition-based stats. Identities = 126/444 (28%), Positives = 213/444 (47%), Gaps = 29/444 (6%) Query: 1 MESLTLQPIAR-VDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTA 59 ME+ T+ P A+ + GTI +PG KS+S+RA++ ALA G T + L D ++ Sbjct: 3 MENKTVIPHAKGLKGTIKVPGDKSISHRAVMFGALAKGTTTVEGFLPGADCLSTISCFQK 62 Query: 60 LGVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEP 119 LGVS + +R + G G E + L +GN+GT R + L V+ G+ Sbjct: 63 LGVSIEQAEERVTVK--GKGWDGLREPSDILDVGNSGTTTRLILGILSTLPFHSVIIGDE 120 Query: 120 RMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSV-SSQFLTALLM 178 + +RP+ + + L+ GA+I + N PL ++GG G +D V S+Q +A+L+ Sbjct: 121 SIGKRPMKRVTEPLKSMGAQIDGRDHGNLTPLSIRGGQLKG-IDFHSPVASAQMKSAILL 179 Query: 179 TAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYL 238 A T + D T +++ FGV IE ++GGQ + Sbjct: 180 AGLRAEGKTSVT-----EPAKTRDHTERMLEAFGVNIEKDGL-TVSIEGGQMLTGQ-HVV 232 Query: 239 VEGDASSASYFLAAAA-IKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDY---- 293 V GD SSA++FL A A + + +T +G N + I +VL++MGAT+ ++ Sbjct: 233 VPGDISSAAFFLVAGAMVPHSRITLTNVGINPTRAGI--LEVLKQMGATLAMENERVQGG 290 Query: 294 -----ISCTRGELNAIDMDMNHIP---DAAMTIATAALFAKGTTTLRNIYNWRVKETDRL 345 ++ L +++ + IP D IA A A G T +++ +VKET+R+ Sbjct: 291 EPVADLTIETSVLQGVEIGGDIIPRLIDEIPIIAVLATQASGRTVIKDAEELKVKETNRI 350 Query: 346 FAMATELRKVGAEVEEGHDYIRITPPEKLNFA-EIATYNDHRMA-MCFSLVALSDTPVTI 403 + +EL K+GA + D + I P L ++++ DHR+ L++ PVT+ Sbjct: 351 DTVVSELTKLGASIHATDDGMIIEGPTPLKGGVTVSSHGDHRIGMAMAIAALLAEKPVTV 410 Query: 404 LDPKCTAKTFPDYFEQLARISQAA 427 + A ++P +F+ L R+ A Sbjct: 411 EGTEAIAVSYPSFFDHLDRLKSEA 434 >1RF6-A nrPDB Length = 427 Score = 386 bits (991), Expect = e-107, Method: Composition-based stats. Identities = 107/431 (24%), Positives = 202/431 (46%), Gaps = 25/431 (5%) Query: 7 QPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTL 66 I + G I +PG KS+S+R+++ +LA G+T + ++L +DV + LGV Sbjct: 5 TNIRHLHGIIRVPGDKSISHRSIIFGSLAEGETKVYDILRGEDVLSTMQVFRDLGVEIED 64 Query: 67 SADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPI 126 + +G G + AL +GN+GT++R ++ L ++ + G+ + +RP+ Sbjct: 65 KDGVITVQGVGMAGLKAPQNALN--MGNSGTSIRLISGVLAGADFEVEMFGDDSLSKRPM 122 Query: 127 GHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSV-SSQFLTALLMTAPLAPE 185 + L+ G I+ + + PPLRL+G + + + S+Q +AL+ A A Sbjct: 123 DRVTLPLKKMGVSISGQTERDLPPLRLKGTKNLRPIHYELPIASAQVKSALMFAALQAKG 182 Query: 186 DTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDASS 245 ++VI + + + T ++++ FG + ++ V+G Q +V GD SS Sbjct: 183 ESVI-----IEKEYTRNHTEDMLQQFGGHLSVDG-KKITVQGPQKLTGQ-KVVVPGDISS 235 Query: 246 ASYFLAAAAI-KGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGD-------DYISCT 297 A+++L A I + + +G N + I DV+ MG + + + Sbjct: 236 AAFWLVAGLIAPNSRLVLQNVGINETRTGI--IDVIRAMGGKLEITEIDPVAKSATLIVE 293 Query: 298 RGELNAIDMDMNHIP---DAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRK 354 +L ++ IP D IA A A+G T +++ +VKETDR+ +A L Sbjct: 294 SSDLKGTEICGALIPRLIDELPIIALLATQAQGVTVIKDAEELKVKETDRIQVVADALNS 353 Query: 355 VGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVAL--SDTPVTILDPKCTAKT 412 +GA++ D + I L+ A + T+ DHR+ M ++ AL +D V + + + Sbjct: 354 MGADITPTADGMIIKGKSALHGARVNTFGDHRIGMMTAIAALLVADGEVELDRAEAINTS 413 Query: 413 FPDYFEQLARI 423 +P +F+ L + Sbjct: 414 YPSFFDDLESL 424 >5BS5-A nrPDB Length = 445 Score = 386 bits (990), Expect = e-107, Method: Composition-based stats. Identities = 125/445 (28%), Positives = 210/445 (47%), Gaps = 34/445 (7%) Query: 2 ESLTLQPIAR-VDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 + ++ P + G +PG KSVS+R+++ A+A G T +T L+ +D L A + Sbjct: 2 QQFSILPGNKAFKGKFTVPGDKSVSHRSIMFGAIAEGTTHVTGFLEGEDALATLQAFRDM 61 Query: 61 GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPR 120 GVS + I G G A L++GN+GT+MR L+ L D V+TG+ Sbjct: 62 GVSIEGPKNG-EVTIHGVGMHGLKAPASALYMGNSGTSMRLLSGMLSAQKFDSVMTGDAS 120 Query: 121 MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSV-SSQFLTALLMT 179 + +RP+ + LRL GA+I ++ PP+ + GG + D + S+Q + +L+ Sbjct: 121 LSKRPMERIAKPLRLMGAQIQTTGEKGTPPVSITGGQQLKGIQYDLPMASAQVKSGILLA 180 Query: 180 APLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLV 239 A +T + +P D T +++ FG +++ + + +V GG+ + V Sbjct: 181 GLWAEGETSVT-----EPEPTRDHTERMLRAFGYDVKTEGNKISLVGGGKLVGT--NIQV 233 Query: 240 EGDASSASYFLAAAAIK-GGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISC-- 296 D SSA++F+ AAI G V + +G N + + ++L++MGA + ++ I+ Sbjct: 234 PSDISSAAFFMVGAAITEGADVVLEAVGINPTRTGV--IEILKQMGADLTVENERIAGGE 291 Query: 297 --------TRGELNAIDMDMNHIP---DAAMTIATAALFAKGTTTLRNIYNWRVKETDRL 345 L I M + +P D + AA A+G T L RVKE+DR+ Sbjct: 292 PIADIHIKGSRTLKGIHMPEDQVPLAIDEFPALFIAAACAEGQTVLTGAAELRVKESDRI 351 Query: 346 FAMATELRKVGAEVEEGHDYIRITPPEKLN-------FAEIATYNDHRMAMCFSLVAL-S 397 MA L+ +G + D I I K EI +++DHR+AM FS+ L + Sbjct: 352 QVMADGLKIMGIDCTPTEDGIIIEGKGKSGDWSPIFAGGEIESHHDHRIAMSFSMAGLRT 411 Query: 398 DTPVTILDPKCTAKTFPDYFEQLAR 422 P+TI + A +FP + E R Sbjct: 412 SGPITIHGTETVATSFPTFTELANR 436 >6CN1-A nrPDB Length = 424 Score = 345 bits (884), Expect = 3e-95, Method: Composition-based stats. Identities = 93/412 (22%), Positives = 161/412 (39%), Gaps = 26/412 (6%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 M+ L + AR+DG I + G+K+ + L LA G + NL D+ M+ + Sbjct: 4 MDKLIITGGARLDGEIRISGAKNAALPILAATLLADGPVTVGNLPHLHDITTMIELFGRM 63 Query: 61 GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPR 120 G+ + + L A L + + + P+ A G ++ L G Sbjct: 64 GIEPVIDEKLSVEIDPRTIKTLVAPYELVKTMRASILVLGPMVARF--GEAEVALPGGCA 121 Query: 121 MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTA 180 + RP+ + L GAKI +E +GG G + D +VS ++M A Sbjct: 122 IGSRPVDLHIRGLEAMGAKIE-VEGGYIKAKAPEGGLRGAHFFFD-TVSVTGTENIMMAA 179 Query: 181 PLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE 240 LA +V++ + +P + N + G I+ + G + S Y V Sbjct: 180 ALAKGRSVLQ---NAAREPEVVDLANFINAMGGNIQGAGTDTITIDGVERLDS-ANYRVM 235 Query: 241 GDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGE 300 D +L AAA+ GG VKV ++ + + L++ GA I G+D+I Sbjct: 236 PDRIETGTYLVAAAVTGGRVKVKDTDPTILEAVL---EKLKEAGADINTGEDWIELDMHG 292 Query: 301 LNAIDMDMNHIPDAAMTIATAALF------AKGT-TTLRNIYNWRVKETDRLFAMATELR 353 +++ P A A F A+GT + I+ R F E+ Sbjct: 293 KRPKAVNLRTAPYPAFPTDMQAQFISLNAIAEGTGAVIETIFENR-------FMHVYEMH 345 Query: 354 KVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILD 405 ++GA+++ + +T + L A + D R + L AL T++D Sbjct: 346 RMGAQIQVEGNTAIVTGVKALKGAPVMA-TDLRASASLVLSALVAEGDTLID 396 >2GG4-A nrPDB Length = 455 Score = 344 bits (881), Expect = 6e-95, Method: Composition-based stats. Identities = 118/444 (26%), Positives = 205/444 (46%), Gaps = 36/444 (8%) Query: 5 TLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSY 64 T + + + GT+ +PG KS+S+R+ + LA G+T +T LL+ +DV + A+ A+G Sbjct: 11 TARKSSGLSGTVRIPGDKSISHRSFMFGGLASGETRITGLLEGEDVINTGKAMQAMGARI 70 Query: 65 TLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKER 124 D + +GNGG L E L GNA T R + + D G+ + +R Sbjct: 71 RKEGDTWIIDGVGNGGLLAPEAP--LDFGNAATGCRLTMGLVGVYDFDSTFIGDASLTKR 128 Query: 125 PIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSV-SSQFLTALLMTAPLA 183 P+G +++ LR G ++ E + P+ L+G T + + S+Q +A+L+ Sbjct: 129 PMGRVLNPLREMGVQVKS-EDGDRLPVTLRGPKTPTPITYRVPMASAQVKSAVLLAGLNT 187 Query: 184 PEDTVIRIKGDLVSKPYIDITLNLMKTFGVEI----ENQHYQQFVVKGGQSYQSPGTYLV 239 P T + + D T +++ FG + + + ++G V Sbjct: 188 PGITTV-----IEPIMTRDHTEKMLQGFGANLTVETDADGVRTIRLEGRGKLTGQ-VIDV 241 Query: 240 EGDASSASYFLAAA-AIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICW-------GD 291 GD SS ++ L AA + G V + + N + + L++MGA I G+ Sbjct: 242 PGDPSSTAFPLVAALLVPGSDVTILNVLMNPTRTGLIL--TLQEMGADIEVINPRLAGGE 299 Query: 292 DY--ISCTRGELNAIDMDMNHIP---DAAMTIATAALFAKGTTTLRNIYNWRVKETDRLF 346 D + L + + + P D +A AA FA+G T + + RVKE+DRL Sbjct: 300 DVADLRVRSSTLKGVTVPEDRAPSMIDEYPILAVAAAFAEGATVMNGLEELRVKESDRLS 359 Query: 347 AMATELRKVGAEVEEGHDYIRITPP------EKLNFAEIATYNDHRMAMCFSLVAL-SDT 399 A+A L+ G + +EG + + + A +AT+ DHR+AM F ++ L S+ Sbjct: 360 AVANGLKLNGVDCDEGETSLVVRGRPDGKGLGNASGAAVATHLDHRIAMSFLVMGLVSEN 419 Query: 400 PVTILDPKCTAKTFPDYFEQLARI 423 PVT+ D A +FP++ + +A + Sbjct: 420 PVTVDDATMIATSFPEFMDLMAGL 443 >3KQA-A nrPDB Length = 419 Score = 343 bits (880), Expect = 8e-95, Method: Composition-based stats. Identities = 96/412 (23%), Positives = 155/412 (37%), Gaps = 29/412 (7%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 M+ +Q R+ G + + G+K+ + L A LA + N+ D+ + LT L Sbjct: 1 MDKFRVQGPTRLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDIDTTMKLLTQL 60 Query: 61 GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPR 120 G N A L + + A+ PL A G + L G Sbjct: 61 GTKVERDGSVWIDASNVNN--FSAPYDLVKTMRASIWALGPLVARF--GQGQVSLPGGCA 116 Query: 121 MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTA 180 + RP+ + L GA+I +E Y + G G ++ +D VS ++ A Sbjct: 117 IGARPVDLHIFGLEKLGAEIKL--EEGYVKASVNGRLKGAHIVMD-KVSVGATVTIMSAA 173 Query: 181 PLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE 240 LA T+I + +P I T N + G +I Q + ++G + G Y V Sbjct: 174 TLAEGTTIIE---NAAREPEIVDTANFLVALGAKISGQGTDRITIEGVERLGG-GVYRVL 229 Query: 241 GDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGE 300 D FL AAAI GG + +++ + L + GA I G+D+IS Sbjct: 230 PDRIETGTFLVAAAISGGKIVCRNAQPDTLDAVL---AKLREAGADIETGEDWISLDMHG 286 Query: 301 LNAIDMDMNHIPDAAMTIATAALF------AKGTTTL-RNIYNWRVKETDRLFAMATELR 353 + + P A A F A+GT + I+ R F EL Sbjct: 287 KRPKAVTVRTAPHPAFPTDMQAQFTLLNLVAEGTGVITETIFENR-------FMHVPELI 339 Query: 354 KVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILD 405 ++GA E + + EKL+ A++ D R + L T++D Sbjct: 340 RMGAHAEIESNTVICHGVEKLSGAQVMA-TDLRASASLVLAGCIAEGTTVVD 390 Score = 43.6 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 58/310 (18%), Positives = 107/310 (34%), Gaps = 30/310 (9%) Query: 57 LTALGVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLT 116 L LG L + + G H + + + G + ++AA L ++ Sbjct: 129 LEKLGAEIKLEEGYVKASVNGRLKGAH----IVMDKVSVGATVTIMSAA-TLAEGTTII- 182 Query: 117 GEPRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTAL 176 E +E I + L GAKI+ + ++G G Sbjct: 183 -ENAAREPEIVDTANFLVALGAKISGQ---GTDRITIEGVERLGGGVYRVLPDRIETGTF 238 Query: 177 LMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIE-NQHYQQFVVKGGQ----SY 231 L+ A ++ V R +D L ++ G +IE + + + G + + Sbjct: 239 LVAAAISGGKIVCRN----AQPDTLDAVLAKLREAGADIETGEDWISLDMHGKRPKAVTV 294 Query: 232 QSPGTYLVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGD 291 ++ D A + L +G V I N + +++ MGA Sbjct: 295 RTAPHPAFPTDM-QAQFTLLNLVAEGTGVITETIFENRF---MHVPELIR-MGAHAEIES 349 Query: 292 DYISCTRGELNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNW-RVKETDRLFAMAT 350 + + C E + M A+ ++ A A+GTT + IY+ R E + Sbjct: 350 NTVICHGVEKLSGAQVMATDLRASASLVLAGCIAEGTTVVDRIYHIDRGYER-----IED 404 Query: 351 ELRKVGAEVE 360 +LR +GA +E Sbjct: 405 KLRALGANIE 414 >2Z2C-A nrPDB Length = 423 Score = 342 bits (878), Expect = 1e-94, Method: Composition-based stats. Identities = 95/412 (23%), Positives = 155/412 (37%), Gaps = 29/412 (7%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 M+ +Q ++ G + + G+K+ + L A LA + N+ DV + L+ L Sbjct: 1 MDKFRVQGPTKLQGEVTISGAKNAALPILFAALLAEEPVEIQNVPKLKDVDTSMKLLSQL 60 Query: 61 GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPR 120 G N A L + + A+ PL A G + L G Sbjct: 61 GAKVERDGSVHIDARDVN--VFCAPYDLVKTMRASIWALGPLVARF--GQGQVSLPGGCT 116 Query: 121 MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTA 180 + RP+ + L GA I +E Y + G G ++ +D VS ++ A Sbjct: 117 IGARPVDLHISGLEQLGATIKL--EEGYVKASVDGRLKGAHIVMD-KVSVGATVTIMCAA 173 Query: 181 PLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE 240 LA T+I + +P I T N + T G +I Q + V++G + G Y V Sbjct: 174 TLAEGTTIIE---NAAREPEIVDTANFLITLGAKISGQGTDRIVIEGVERLGG-GVYRVL 229 Query: 241 GDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGE 300 D FL AAAI G + +++ + L GA I G+D+IS Sbjct: 230 PDRIETGTFLVAAAISRGKIICRNAQPDTLDAVL---AKLRDAGADIEVGEDWISLDMHG 286 Query: 301 LNAIDMDMNHIPDAAMTIATAALF------AKGTTTL-RNIYNWRVKETDRLFAMATELR 353 +++ P A A F A+GT + ++ R F EL Sbjct: 287 KRPKAVNVRTAPHPAFPTDMQAQFTLLNLVAEGTGFITETVFENR-------FMHVPELS 339 Query: 354 KVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILD 405 ++GA E + + EKL+ A++ D R + L T++D Sbjct: 340 RMGAHAEIESNTVICHGVEKLSGAQVMA-TDLRASASLVLAGCIAEGTTVVD 390 Score = 42.0 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 61/339 (17%), Positives = 115/339 (33%), Gaps = 32/339 (9%) Query: 30 LLAALAHGKTVLTN--LLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLHAEGA 87 L+A G+ L + + V ++ L LG + L + + G H Sbjct: 100 LVARFGQGQVSLPGGCTIGARPVDLHISGLEQLGATIKLEEGYVKASVDGRLKGAH---- 155 Query: 88 LELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVDALRLGGAKITYLEQEN 147 + + + G + + AA L ++ E +E I + L GAKI+ Sbjct: 156 IVMDKVSVGATVTIMCAA-TLAEGTTII--ENAAREPEIVDTANFLITLGAKISGQ---G 209 Query: 148 YPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDITLNL 207 + ++G G L+ A ++ + R +D L Sbjct: 210 TDRIVIEGVERLGGGVYRVLPDRIETGTFLVAAAISRGKIICRN----AQPDTLDAVLAK 265 Query: 208 MKTFGVEIE-NQHYQQFVVKGGQ----SYQSPGTYLVEGDASSASYFLAAAAIKGGTVKV 262 ++ G +IE + + + G + + ++ D A + L +G Sbjct: 266 LRDAGADIEVGEDWISLDMHGKRPKAVNVRTAPHPAFPTDM-QAQFTLLNLVAEGTGFIT 324 Query: 263 TGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGELNAIDMDMNHIPDAAMTIATAA 322 + N L +MGA + + C E + M A+ ++ A Sbjct: 325 ETVFENR----FMHVPELSRMGAHAEIESNTVICHGVEKLSGAQVMATDLRASASLVLAG 380 Query: 323 LFAKGTTTLRNIYNW-RVKETDRLFAMATELRKVGAEVE 360 A+GTT + IY+ R E + +LR +GA +E Sbjct: 381 CIAEGTTVVDRIYHIDRGYER-----IEDKLRALGANIE 414 >5BQ2-A nrPDB Length = 429 Score = 341 bits (874), Expect = 4e-94, Method: Composition-based stats. Identities = 90/412 (21%), Positives = 156/412 (37%), Gaps = 26/412 (6%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 M+ L + R+DG I + G+K+ + L LA + NL D+ M+ + Sbjct: 9 MDKLIITGGNRLDGEIRISGAKNSALPILAATLLADTPVTVCNLPHLHDITTMIELFGRM 68 Query: 61 GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPR 120 GV + + L A L + + + P+ A G ++ L G Sbjct: 69 GVQPIIDEKLNVEVDASSIKTLVAPYELVKTMRASILVLGPMLARF--GEAEVALPGGCA 126 Query: 121 MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTA 180 + RP+ + L GA+I +E GG GG+ D +VS L+M A Sbjct: 127 IGSRPVDLHIRGLEAMGAQIE-VEGGYIKAKAPAGGLRGGHFFFD-TVSVTGTENLMMAA 184 Query: 181 PLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE 240 LA TV++ + +P + N + G ++ V++G + Y V Sbjct: 185 ALANGRTVLQ---NAAREPEVVDLANCLNAMGANVQGAGSDTIVIEGVKRLGG-ARYDVL 240 Query: 241 GDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGE 300 D +L AAA GG VK+ ++ ++ LE+ GA I G ++I Sbjct: 241 PDRIETGTYLVAAAATGGRVKLKDTDPTILEAVLQ---KLEEAGAHISTGSNWIELDMKG 297 Query: 301 LNAIDMDMNHIPDAAMTIATAALF------AKGT-TTLRNIYNWRVKETDRLFAMATELR 353 +++ P A A F A+GT + ++ R F E+ Sbjct: 298 NRPKAVNVRTAPYPAFPTDMQAQFISMNAVAEGTGAVIETVFENR-------FMHVYEMN 350 Query: 354 KVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILD 405 ++GA++ + +T KL A + D R + + L T++D Sbjct: 351 RMGAQILVEGNTAIVTGVPKLKGAPVMA-TDLRASASLVIAGLVAEGDTLID 401 >5U4H-A nrPDB Length = 421 Score = 332 bits (851), Expect = 2e-91, Method: Composition-based stats. Identities = 102/406 (25%), Positives = 160/406 (39%), Gaps = 16/406 (3%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 M+ + +++G + + G+K+ + L LA LTN+ + DV ++ + L Sbjct: 4 MDKFLITGGVKLEGEVRISGAKNAALPLLAAMILADSPITLTNVPNLKDVNTLVKLIGGL 63 Query: 61 GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPR 120 GV+ + D + + A L + + + PL A G+ + L G Sbjct: 64 GVTISYENDTVKADTSTLDNQF-APYELVKTMRASILVLGPLLAR--YGNAKVSLPGGCA 120 Query: 121 MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTA 180 + RP+ + AL GA I + Y + G GG V D V+ +LM A Sbjct: 121 IGSRPVDQHLKALEALGAHIEV--ENGYVHATVDGRLKGGEVVFD-MVTVGGTENILMAA 177 Query: 181 PLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE 240 LA T IR + +P I ++ G +IE VV G +S Y V Sbjct: 178 ALADGVTTIR---NAAREPEITDLAQMLIKMGAKIEGLDTDTLVVTGVESLHGC-EYAVV 233 Query: 241 GDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGE 300 D +LAAAAI GG VK T + ++ + D E+MGA + GDD+I Sbjct: 234 ADRIETGSYLAAAAITGGRVKTTHTDPSLLEAVL---DKFEEMGAEVTRGDDWIELDMLG 290 Query: 301 LNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVE 360 + +P A R + F EL ++GA ++ Sbjct: 291 KRPKAVSFRTLPHPEFPTDMQAQIMAVNAIGRGFATISETIFENRFMHVPELSRMGANIQ 350 Query: 361 -EGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILD 405 EGHD + +T EKL A + D R + L AL T++D Sbjct: 351 VEGHDAV-VTGVEKLQAAPVMA-TDLRASFSLVLAALVAEGDTLID 394 >2RL1-A nrPDB Length = 424 Score = 329 bits (844), Expect = 1e-90, Method: Composition-based stats. Identities = 95/414 (22%), Positives = 161/414 (38%), Gaps = 31/414 (7%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 M+ + +R+ G++N+ G+K+ + L A LA LTN+ + D+ L L L Sbjct: 1 MDKFRVYGQSRLSGSVNISGAKNAALPILFAAILATEPVKLTNVPELKDIETTLKILRQL 60 Query: 61 GVSYTLSADRTRCEIIGNGGPLHAEGALELF--LGNAGTAMRPLAAALCLGSNDIVLTGE 118 GV + D T ++ H EL + + A+ PL A G + L G Sbjct: 61 GV--VVDRDATGAVLLDASNINHFTAPYELVKTMRASIWALAPLVARFHQGQ--VSLPGG 116 Query: 119 PRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLM 178 + RP+ + L GA I +E Y ++ G + ++ VS +++M Sbjct: 117 CSIGARPVDLHISGLEKLGADIVL--EEGYVKAQVSDRLVGTRIVIE-KVSVGATLSIMM 173 Query: 179 TAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYL 238 A LA TVI + +P I T + + G +I ++G + + Sbjct: 174 AATLAKGTTVIE---NAAREPEIVDTADFLNKMGAKITGAGSAHITIEGVERLTGCEHSV 230 Query: 239 VEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTR 298 V D FL AAAI GG V +++ I D L + GA + ++ I+ Sbjct: 231 VP-DRIETGTFLIAAAISGGCVVCQNTKADTLDAVI---DKLREAGAQVDVTENSITLDM 286 Query: 299 GELNAIDMDMNHIPDAAMTIATAALF------AKGTTTL-RNIYNWRVKETDRLFAMATE 351 +++ P A F A+GT+ + I+ R F E Sbjct: 287 LGNRPKAVNIRTAPHPGFPTDMQAQFTLLNMVAEGTSIITETIFENR-------FMHIPE 339 Query: 352 LRKVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILD 405 L ++G + E + E+L+ E+ D R ++ L T TI+D Sbjct: 340 LIRMGGKAEIEGNTAVCHGVEQLSGTEVIA-TDLRASISLVLAGCIATGETIVD 392 >3VCY-A nrPDB Length = 430 Score = 318 bits (816), Expect = 2e-87, Method: Composition-based stats. Identities = 90/415 (21%), Positives = 155/415 (37%), Gaps = 34/415 (8%) Query: 1 MESLTLQPIAR-VDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTA 59 M+ +Q + + G + + G+K+ + L + LA + N+ DV + L Sbjct: 1 MDKFRIQGSDKPLSGEVTISGAKNAALPILFASLLAEEPVEVANVPKLRDVDTTMELLKR 60 Query: 60 LGVSYTLSADRTRCEIIGNGGPLHAEGALELF--LGNAGTAMRPLAAALCLGSNDIVLTG 117 LG + R I G +L + + A+ PL A G + L G Sbjct: 61 LGAEVS----RNGSVHIDASGVNDFCAPYDLVKTMRASIWALGPLVARF--GKGQVSLPG 114 Query: 118 EPRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALL 177 + RP+ + L GA I +E Y + G G ++ +D VS ++ Sbjct: 115 GCAIGARPVDLHIHGLEQLGATIKL--EEGYVKAEVDGRLKGAHIVMD-KVSVGATITVM 171 Query: 178 MTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTY 237 A LA TV+ + +P I T N + G ++ ++G + G + Sbjct: 172 CAATLAEGTTVLE---NAAREPEIVDTANFLNAIGAKVSGMGTDTITIEGVERLGG-GYH 227 Query: 238 LVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCT 297 V D FL AAA+ GG + + ++ + LE+ GA + GDD+IS Sbjct: 228 EVVADRIETGTFLVAAAVSGGKIVCKNTKAHLLEAVL---AKLEEAGADVQTGDDWISLD 284 Query: 298 RGELNAIDMDMNHIPDAAMTIATAALF------AKGTTTL-RNIYNWRVKETDRLFAMAT 350 +++ P A A F AKG+ + I+ R F Sbjct: 285 MTGRELKAVNIRTAPHPAFPTDMQAQFTLLNMMAKGSGIITETIFENR-------FMHIP 337 Query: 351 ELRKVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILD 405 EL+++GA E + + L+ A++ D R + + TI+D Sbjct: 338 ELQRMGAHAEIEGNTAICGDTDGLSGAQVMA-TDLRASASLVIAGCIAKGETIVD 391 >2O0B-A nrPDB Length = 450 Score = 315 bits (808), Expect = 2e-86, Method: Composition-based stats. Identities = 131/426 (30%), Positives = 207/426 (48%), Gaps = 20/426 (4%) Query: 7 QPIARVDGTINLPGSKSVSNRALLLAAL----AHGKTVLTNLLDSDDVRHMLNALTALGV 62 V T+ +PGSKS +NRAL+LAAL G + ++ L S D ML+AL LG Sbjct: 8 TAPTPVRATVTVPGSKSQTNRALVLAALAAAQGRGASTISGALRSRDTELMLDALQTLG- 66 Query: 63 SYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMK 122 L D E+ +G GA + G AGT +R + LGS + G+ + + Sbjct: 67 ---LRVDGVGSELTVSGRIEPGPGA-RVDCGLAGTVLRFVPPLAALGSVPVTFDGDQQAR 122 Query: 123 ERPIGHLVDALRLGGAKITYLEQENYP-PLRLQGGFTGGNVDVDGSVSSQFLTALLMTAP 181 RPI L+DALR G + + P +R G GG V +D S SSQF++ LL++A Sbjct: 123 GRPIAPLLDALRELGVAV---DGTGLPFRVRGNGSLAGGTVAIDASASSQFVSGLLLSAA 179 Query: 182 LAPEDTVIRIKGD-LVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE 240 + ++ G L S P+I +T +++ GV+I++ ++ V+ G + +E Sbjct: 180 SFTDGLTVQHTGSSLPSAPHIAMTAAMLRQAGVDIDDSTPNRWQVRPGPVAAR--RWDIE 237 Query: 241 GDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTR-G 299 D ++A FL+AA + GGTV++TG R S+Q +L ++ A + D + Sbjct: 238 PDLTNAVAFLSAAVVSGGTVRITGWPRVSVQPADHILAILRQLNAVVIHADSSLEVRGPT 297 Query: 300 ELNAIDMDMNHIPDAAMTIATAALFAK--GTTTLRNIYNWRVKETDRLFAMATELRKVGA 357 + D+D+ + + ++A A A + L I + R ETDRL A++TE+ ++G Sbjct: 298 GYDGFDVDLRAVGELTPSVAALAALASPGSVSRLSGIAHLRGHETDRLAALSTEINRLGG 357 Query: 358 EVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTFPDYF 417 E D + IT L Y DHRMAM +++ L V + D T KT P++ Sbjct: 358 TCRETPDGLVIT-ATPLRPGIWRAYADHRMAMAGAIIGLRVAGVEVDDIAATTKTLPEFP 416 Query: 418 EQLARI 423 A + Sbjct: 417 RLWAEM 422 >4R7U-A nrPDB Length = 422 Score = 309 bits (792), Expect = 1e-84, Method: Composition-based stats. Identities = 86/415 (20%), Positives = 152/415 (36%), Gaps = 34/415 (8%) Query: 1 MESLTLQPIAR-VDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTA 59 ME + + + G + + G+K+ + L + LA + N+ D+ + L Sbjct: 4 MEKFRVIGSTQPLQGEVTISGAKNAALPILFASILAEEPVEVANVPHLRDIDTTMELLER 63 Query: 60 LGVSYTLSADRTRCEIIGNGGPLHAEGALELF--LGNAGTAMRPLAAALCLGSNDIVLTG 117 LG R + G +L + + A+ PL A G + L G Sbjct: 64 LGAKVE----RNGSVHVDAGPINQYCAPYDLVKTMRASIWALGPLVARF--GQGQVSLPG 117 Query: 118 EPRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALL 177 + RP+ + L GA IT ++ Y + G G ++ +D VS ++ Sbjct: 118 GCAIGARPVDLHIHGLEQLGATITL--EDGYVKAHVDGRLQGAHIVMD-KVSVGATITIM 174 Query: 178 MTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTY 237 A LA TV+ + +P I T + G +I ++G + G + Sbjct: 175 CAATLAEGTTVLD---NAAREPEIVDTAMFLNKLGAKISGAGTDSITIEGVERLGG-GKH 230 Query: 238 LVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCT 297 V D FL AAA+ G + + ++ + LE+ GA I G+D+IS Sbjct: 231 AVVPDRIETGTFLVAAAVSRGKIVCRNTHAHLLEAVL---AKLEEAGAEIECGEDWISLD 287 Query: 298 RGELNAIDMDMNHIPDAAMTIATAALF------AKGTTTL-RNIYNWRVKETDRLFAMAT 350 + + P A F AKG + I+ R F Sbjct: 288 MTGRELKAVTVRTAPHPGFPTDMQAQFTLLNMMAKGGGVITETIFENR-------FMHVP 340 Query: 351 ELRKVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILD 405 EL+++GA+ E + + ++L+ A++ D R + + TI+D Sbjct: 341 ELKRMGAKAEIEGNTVICGDVDRLSGAQVMA-TDLRASASLVIAGCIAKGETIVD 394 >3TI2-A nrPDB Length = 228 Score = 274 bits (701), Expect = 5e-74, Method: Composition-based stats. Identities = 165/228 (72%), Positives = 186/228 (81%), Gaps = 1/228 (0%) Query: 16 INLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEI 75 +NLPGSKSVSNRALLLAALA G T LTNLLDSDD+RHMLNALT LGV+Y LSAD+T CE+ Sbjct: 1 VNLPGSKSVSNRALLLAALASGTTRLTNLLDSDDIRHMLNALTKLGVNYRLSADKTTCEV 60 Query: 76 IGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVDALRL 135 G G H LELFLGNAGTAMRPLAAALCLG D VLTGEPRMKERPIGHLVDALR Sbjct: 61 EGLGQAFHTTQPLELFLGNAGTAMRPLAAALCLGQGDYVLTGEPRMKERPIGHLVDALRQ 120 Query: 136 GGAKITYLEQENYPPLRLQG-GFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGD 194 GA+I YLEQEN+PPLR+QG G G V +DGS+SSQFLTA LM+APLA I+I G+ Sbjct: 121 AGAQIEYLEQENFPPLRIQGTGLQAGTVTIDGSISSQFLTAFLMSAPLAQGKVTIKIVGE 180 Query: 195 LVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGD 242 LVSKPYIDITL++M+ FGV++ N YQ+FV+ GQSY SPG +LVEGD Sbjct: 181 LVSKPYIDITLHIMEQFGVQVINHDYQEFVIPAGQSYVSPGQFLVEGD 228 Score = 48.2 bits (113), Expect = 7e-06, Method: Composition-based stats. Identities = 39/201 (19%), Positives = 71/201 (35%), Gaps = 10/201 (4%) Query: 194 DLVSKPYIDITLNLMKTFGVEIE-NQHYQQFVVKG-GQSY-QSPGTYLVEGDASSASYFL 250 +L+ I LN + GV + V+G GQ++ + L G+A +A L Sbjct: 28 NLLDSDDIRHMLNALTKLGVNYRLSADKTTCEVEGLGQAFHTTQPLELFLGNAGTAMRPL 87 Query: 251 AAAAIKG-GTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDY----ISCTRGELNA-- 303 AAA G G +TG R + D L + GA I + + + L A Sbjct: 88 AAALCLGQGDYVLTGEPRMKERPIGHLVDALRQAGAQIEYLEQENFPPLRIQGTGLQAGT 147 Query: 304 IDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVEEGH 363 + +D + +A A+G T++ + K + E V + Sbjct: 148 VTIDGSISSQFLTAFLMSAPLAQGKVTIKIVGELVSKPYIDITLHIMEQFGVQVINHDYQ 207 Query: 364 DYIRITPPEKLNFAEIATYND 384 +++ ++ + D Sbjct: 208 EFVIPAGQSYVSPGQFLVEGD 228 >1P88-A nrPDB Length = 216 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 216/216 (100%), Positives = 216/216 (100%) Query: 25 SNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLHA 84 SNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLHA Sbjct: 1 SNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLHA 60 Query: 85 EGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVDALRLGGAKITYLE 144 EGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVDALRLGGAKITYLE Sbjct: 61 EGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVDALRLGGAKITYLE 120 Query: 145 QENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDIT 204 QENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDIT Sbjct: 121 QENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDIT 180 Query: 205 LNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE 240 LNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE Sbjct: 181 LNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE 216 >5WI5-A nrPDB Length = 430 Score = 243 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 88/427 (20%), Positives = 157/427 (36%), Gaps = 18/427 (4%) Query: 1 MESLTLQPI-ARVDGTINLPGSKSVSNRALLLAALA-HGKTVLTNLLDSDDVRHMLNALT 58 M+ + +Q R+ G++ + G+K+ L LA GKTVL N+ DV M + Sbjct: 4 MDKIVVQGGDNRLVGSVTIEGAKNAVLPLLAATILASEGKTVLQNVPILSDVFIMNQVVG 63 Query: 59 ALGVSYTLSADRTRCEIIGNGG-PLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTG 117 L + ++ G A + + + P+ A + G + + G Sbjct: 64 GLNAKVDFDEEAHLVKVDATGDITEEAPYKYVSKMRASIVVLGPILARV--GHAKVSMPG 121 Query: 118 EPRMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALL 177 + RPI + L G KI+ + Y + + G ++ +D S L+ Sbjct: 122 GCTIGSRPIDLHLKGLEAMGVKIS--QTAGYIEAKAE-RLHGAHIYMDFP-SVGATQNLM 177 Query: 178 MTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTY 237 M A LA TVI + +P I L+ G +++ + + G + Sbjct: 178 MAATLADGVTVIE---NAAREPEIVDLAILLNEMGAKVKGAGTETITITGVEKLHGTTHN 234 Query: 238 LVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCT 297 +V+ D A F+ AAA+ GG V + + L +MG + D+ I Sbjct: 235 VVQ-DRIEAGTFMVAAAMTGGDVLIRDAVWEHNRP---LIAKLLEMGVEVIEEDEGIRVR 290 Query: 298 RGELNAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGA 357 N + + +P A F T + + F E+R++G Sbjct: 291 SQLENLKAVHVKTLPHPGFPTDMQAQFTALMTVAKGESTMVETVFENRFQHLEEMRRMGL 350 Query: 358 EVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKC-TAKTFPDY 416 E D RI + L AE+ + D R + L L T++ + + + Sbjct: 351 HSEIIRDTARIVGGQPLQGAEVLS-TDLRASAALILTGLVAQGETVVGKLVHLDRGYYGF 409 Query: 417 FEQLARI 423 E+LA++ Sbjct: 410 HEKLAQL 416 >3SG1-A nrPDB Length = 458 Score = 235 bits (598), Expect = 4e-62, Method: Composition-based stats. Identities = 83/430 (19%), Positives = 159/430 (36%), Gaps = 27/430 (6%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALA-HGKTVLTNLLDSDDVRHMLNALTA 59 ME + ++ R++GT+ + G+K+ + A LA GK VL+ + DV + L Sbjct: 25 MEKIIVRGGKRLNGTVRVEGAKNAVLPIIAAALLASDGKNVLSEVPVLSDVYTINEVLRH 84 Query: 60 LGVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEP 119 L ++ + A + + M PL A G I L G Sbjct: 85 LNAEVVFENNQVTIDASKELNIE-APFEYVRKMRASVQVMGPLLAR--NGRARIALPGGC 141 Query: 120 RMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMT 179 + RPI + GAK+ + ++G G + +D S ++ Sbjct: 142 AIGSRPIDQHLKGFEAMGAKVQV--GNGFVEAYVEGELKGAKIYLDFP-SVGATENIMSA 198 Query: 180 APLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLV 239 A LA T++ + +P I N + G ++ ++G ++ Sbjct: 199 ATLAKGTTILE---NAAKEPEIVDLANFLNAMGAKVRGAGTGTIRIEGVDKLYGANHSII 255 Query: 240 EGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRG 299 D A F+ AAAI GG + + ++ +E+MG I ++ + Sbjct: 256 P-DRIEAGTFMVAAAITGGDILIENAVPEHLRS---ITAKMEEMGVKIIEENEGVRVIGP 311 Query: 300 E-LNAIDMDMNHIP----DAAMTIATAALFAKGTTTL-RNIYNWRVKETDRLFAMATELR 353 + L A+D+ P D + L A GT+ + ++ R F E R Sbjct: 312 DKLKAVDIKTMPHPGFPTDMQSQMMALLLQADGTSMITETVFENR-------FMHVEEFR 364 Query: 354 KVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTF 413 ++ A+++ + + P L AE+ + A +S+ + + K + + Sbjct: 365 RMNADIKIEGRSVIMNGPNSLQGAEVGATDLRAAAALILAGLVSEGYTRVTELKHLDRGY 424 Query: 414 PDYFEQLARI 423 D+ ++LA + Sbjct: 425 VDFHKKLAAL 434 >3R38-A nrPDB Length = 454 Score = 226 bits (576), Expect = 2e-59, Method: Composition-based stats. Identities = 86/430 (20%), Positives = 165/430 (38%), Gaps = 28/430 (6%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAH-GKTVLTNLLDSDDVRHMLNALTA 59 ME + ++ +++G++ + G+K+ + LA G +VL N+ + DV + L Sbjct: 25 MEKIIVRGGKQLNGSVKMEGAKNAVLPVIAATLLASKGTSVLKNVPNLSDVFTINEVLKY 84 Query: 60 LGVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEP 119 L + D + G A + + M PL A GS + L G Sbjct: 85 LNADVSFVNDEVTVDATGE-ITSDAPFEYVRKMRASIVVMGPLLAR--TGSARVALPGGC 141 Query: 120 RMKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMT 179 + RP+ + GA + + Y + G V +D S ++M Sbjct: 142 AIGSRPVDLHLKGFEAMGAVVKI--ENGYIEATAE-KLVGAKVYLDFP-SVGATQNIMMA 197 Query: 180 APLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLV 239 A LA TVI ++ +P I N + G + + ++G + + ++ Sbjct: 198 ATLAEGTTVIE---NVAREPEIVDLANFLNQMGARVIGAGTEVIRIEGVKELTATEHSII 254 Query: 240 EGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRG 299 D A F+ AAAI GG V + + LE+MG I ++ I Sbjct: 255 P-DRIEAGTFMIAAAITGGNVLIEDAVP---EHISSLIAKLEEMGVQIIEEENGIRVIGP 310 Query: 300 E-LNAIDMDMNHIP----DAAMTIATAALFAKGTTTL-RNIYNWRVKETDRLFAMATELR 353 + L A+D+ P D + + ++GT+ + ++ R F E+R Sbjct: 311 DKLKAVDVKTMPHPGFPTDMQSQMMVIQMLSEGTSIMTETVFENR-------FMHVEEMR 363 Query: 354 KVGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILDPKCTAKTF 413 ++ A+++ + I+ P KL AE+A + A ++D + + K + + Sbjct: 364 RMNADMKIEGHSVIISGPAKLQGAEVAATDLRAAAALILAGLVADGYTQVTELKYLDRGY 423 Query: 414 PDYFEQLARI 423 ++ +L + Sbjct: 424 NNFHGKLQAL 433 >2YVW-A nrPDB Length = 425 Score = 219 bits (557), Expect = 3e-57, Method: Composition-based stats. Identities = 74/410 (18%), Positives = 152/410 (37%), Gaps = 30/410 (7%) Query: 2 ESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALG 61 + ++ + G + + G+K+ + + L +TN+ D DVR+ L L LG Sbjct: 11 DYFVIRGGKPLTGKVKISGAKNAALPIMFATILTEEPCTITNVPDLLDVRNTLLLLRELG 70 Query: 62 VSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRM 121 + N + + + ++ PL G + L G + Sbjct: 71 AELEFLNNTVFINPSINS--FITNQEIIRRMRASVLSLGPLLGRF--GRAVVGLPGGCSI 126 Query: 122 KERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAP 181 RPI + + GA + E Y L+ + D V+ L+ Sbjct: 127 GARPIDQHLKFFKEAGADVEVREGYVYVNLK---EKRRVHFKFDL-VTVTGTENALLYLA 182 Query: 182 LAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEG 241 PE++++ ++ +P + + ++K G ++ + + VKG ++ + ++ Sbjct: 183 SVPEESILE---NIALEPEVMDLIEVLKKMGAHVKVEG-RSAYVKGSENLKGFTHSVIP- 237 Query: 242 DASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGE- 300 D A F+ A + G + + N ++ + + L+ +G + + + R E Sbjct: 238 DRIEAGTFMVGAVLTDGEILLENARINHLRAVV---EKLKLIGGEVVEENGNLRVFRKES 294 Query: 301 LNAIDMDMNHIP----DAAMTIATAALFAKGTTTL-RNIYNWRVKETDRLFAMATELRKV 355 L A D++ P D AKG + + NI+ R F A EL ++ Sbjct: 295 LRACDIETQVYPGFPTDMQAQFMALLSVAKGKSRIKENIFEHR-------FHHAQELNRL 347 Query: 356 GAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTPVTILD 405 GA + + + E+L +E+ + D R + L L T++ Sbjct: 348 GANITVRGNTAYVEGVERLYGSEVYS-TDLRASASLVLAGLVAQGETVVR 396 Score = 28.6 bits (62), Expect = 6.0, Method: Composition-based stats. Identities = 16/70 (22%), Positives = 24/70 (34%), Gaps = 5/70 (7%) Query: 128 HLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDT 187 H L GA IT Y + G V S + +L++ +A +T Sbjct: 339 HHAQELNRLGANITVRGNTAY--VEGVERLYGSEVY---STDLRASASLVLAGLVAQGET 393 Query: 188 VIRIKGDLVS 197 V+R L Sbjct: 394 VVRDVYHLDR 403 >5UJS-A nrPDB Length = 442 Score = 213 bits (542), Expect = 1e-55, Method: Composition-based stats. Identities = 75/394 (19%), Positives = 156/394 (39%), Gaps = 31/394 (7%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 M L ++ + G + + G+K+ + ++ + LA + + N+ + D++ +++ L L Sbjct: 25 MTYLEIEGTNHLSGNVTISGAKNAALPLIVSSILAKNEVKINNVPNVADIKTLISLLENL 84 Query: 61 GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPR 120 G + + A+ + + + + PL A G ++ L G Sbjct: 85 GAKVNFQNNSALLNTNTLNQTI-AKYDIVRKMRASILTLGPLLARF--GHCEVSLPGGCA 141 Query: 121 MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTA 180 + +RPI + AL GA I ++Q G G + D ++ ++M A Sbjct: 142 IGQRPIDLHLLALEKMGANIQ-IKQGYVVA---SGNLKGNEILFD-KITVTGSENIIMAA 196 Query: 181 PLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKG--GQSYQSPGTYL 238 LA T + ++ +P + ++K G+EI+ + + G G+ + + Sbjct: 197 ALAKGKTKL---LNVAKEPEVVQLCEVLKDAGLEIKGIGTDELEIYGSDGELLE-FKEFS 252 Query: 239 VEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYIS-CT 297 V D A +L A AI + + + + + L +MG +D I+ Sbjct: 253 VIPDRIEAGTYLCAGAITNSKITLDKVNATHLSAVL---AKLHQMGFETLITEDSITLLP 309 Query: 298 RGELNAIDMDMNHIP----DAAMTIATAALFAKGTTTL-RNIYNWRVKETDRLFAMATEL 352 E+ +++ + P D AL A GT+ + ++ R F +EL Sbjct: 310 AKEIKPVEIMTSEYPGFPTDMQAQFMALALKANGTSIIDERLFENR-------FMHVSEL 362 Query: 353 RKVGAEVEEGHDYIRITPPEKLNFAEIATYNDHR 386 ++GA+++ I ++LN A++ D R Sbjct: 363 LRMGADIKLNGHIATIVGGKELNAADVMA-TDLR 395 >3ZH3-A nrPDB Length = 419 Score = 205 bits (521), Expect = 3e-53, Method: Composition-based stats. Identities = 86/430 (20%), Positives = 151/430 (35%), Gaps = 27/430 (6%) Query: 1 MESLTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTAL 60 M + + + G I + G+K+ + LA L + D DV ++ + + Sbjct: 1 MRKIVINGGLPLQGEITISGAKNSVVALIPAIILADDVVTLDCVPDISDVASLVEIMELM 60 Query: 61 GVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALCLGSNDIVLTGEPR 120 G + D + G G + L + L G + L G Sbjct: 61 GATVKRYDDVLEIDPRGVQNIPMPYGKIN-SLRASYYFYGSLLGRF--GEATVGLPGGCD 117 Query: 121 MKERPIGHLVDALRLGGAKITYLEQENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTA 180 + RPI + A GA +Y E +N G G ++ +D +VS ++ A Sbjct: 118 LGPRPIDLHLKAFEAMGATASY-EGDNMKLSAKDTGLHGASIYMD-TVSVGATINTMIAA 175 Query: 181 PLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE 240 A T+I + +P I L+ G I ++ G + + V Sbjct: 176 VKANGRTIIE---NAAREPEIIDVATLLNNMGAHIRGAGTNIIIIDGVERLHG-TRHQVI 231 Query: 241 GDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISC-TRG 299 D A +++ AA G +++ + ++G F LE+MG + +D I + Sbjct: 232 PDRIEAGTYISLAAAVGKGIRINNVLYEHLEG---FIAKLEEMGVRMTVSEDSIFVEEQS 288 Query: 300 ELNAIDMDMNHIP----DAAMTIATAALFAKGT-TTLRNIYNWRVKETDRLFAMATELRK 354 L AI++ P D + L A G T + IY RV EL K Sbjct: 289 NLKAINIKTAPYPGFATDLQQPLTPLLLRANGRGTIVDTIYEKRVN-------HVFELAK 341 Query: 355 VGAEVEEGHDYIRITPPEKLNFAEIATYNDHRMAMCFSLVALSDTP-VTILDPKCTAKTF 413 + A++ + +I T L A + D R + L I + + + + Sbjct: 342 MDADISTTNGHILYTGGRDLRGASVKA-TDLRAGAALVIAGLMAEGKTEITNIEFILRGY 400 Query: 414 PDYFEQLARI 423 D E+L + Sbjct: 401 SDIIEKLRNL 410 >4FQD-A nrPDB Length = 479 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 77/444 (17%), Positives = 149/444 (33%), Gaps = 35/444 (7%) Query: 4 LTLQPIARVDGTINLPGSKSVSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVS 63 L + R+ G + G K + AA A + N D + + A G Sbjct: 16 LEIHGGNRLSGAVRTSGFKHSLVTTVAAAATASAPVRIENCPDIVETAVLGEIFRAAGAH 75 Query: 64 YTLSADRTRCEIIGNGGPLHAEGALELFLGNAGTAMRPLAAALC-LGSNDIVLTGEPRMK 122 + + A +G ++ L A + G + +G + Sbjct: 76 AHYDGADETFTVDASAWDRAELPAD--LVGRIHGSLYLLPALVSRNGVARLSASGGCPIG 133 Query: 123 E----RPIGHLVDALRLGGAKITYLEQEN-------YPPLRLQG-GFTGGNVDVDGSVSS 170 E RP HL+D + G + P + +T + G S Sbjct: 134 EGPRGRPDEHLLDVMGRFGVTTRLTADGSVDLTAQRLTPCTIDMLDYTRNKALMSGPCYS 193 Query: 171 QFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIENQHYQQFVV--KGG 228 + L+ + T ++ KP + + +++ G +IE + +V+ +G Sbjct: 194 GAVKTALLMGAVTHGTTTLQHPYL---KPDVTDMVTVLRDLGADIEFAGPETWVIHGRGP 250 Query: 229 QSYQSPGTYLVEGDASSASYFLAAAAIKGGT-VKVTGIGRN-SMQGDIRFADVLEKMGAT 286 +S P + D ++ A + +++TG G + ++ D+L++MG Sbjct: 251 ESLHRPVDVTLIPDLIEVVTWICAGVLLADEPLRITGPGIDRAVHALAPEFDLLDRMGVR 310 Query: 287 ICWGDDYISCT--RGELNAID---MDMNHIPDAAMTIATAALFAKGTTTLRNIYNWRVKE 341 + G D ++ L ++ M D+ +A +A+G T +R Sbjct: 311 VDVGADEVTAHPLTKPLRPVEFTAMSRGVFSDSQPFLALLGAYAEGPTYIREAV------ 364 Query: 342 TDRLFAMATELRKVGAEVEEGHDYIRITPP-EKLNFAEIATYNDHRMAMCFSLVALSDTP 400 + F A EL +G +R+ P D R A L AL+ Sbjct: 365 WEHRFGFAPELEALGIRTAVDDTVLRVDGPCPPHRPGTDLRATDLRAAAVLLLAALAVPG 424 Query: 401 -VTILDPKCTAKTFPDYFEQLARI 423 T+ + A+ + D E L ++ Sbjct: 425 RTTLRNHHHLARGYRDLVEDLVKL 448 Score = 42.0 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 58/276 (21%), Positives = 83/276 (30%), Gaps = 30/276 (10%) Query: 28 ALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLHAEGA 87 ALL+ A+ HG T L + DV M+ L LG + T +H G Sbjct: 199 ALLMGAVTHGTTTLQHPYLKPDVTDMVTVLRDLGADIEFAGPET--------WVIHGRGP 250 Query: 88 LELFLGNAGTAMRPLAAALCLGSNDIVLTGEP-RMKERPIGHLVDALR-------LGGAK 139 L T + L + ++L EP R+ I V AL G + Sbjct: 251 ESLHRPVDVTLIPDLIEVVTWICAGVLLADEPLRITGPGIDRAVHALAPEFDLLDRMGVR 310 Query: 140 ITYLEQENYPPLRLQGGFTGGNVD-VDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVS- 197 + E L + V S L + A T IR Sbjct: 311 VDVGADE-VTAHPLTKPLRPVEFTAMSRGVFSDSQPFLALLGAYAEGPTYIREAVWEHRF 369 Query: 198 --KPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDASSASYFLAAAAI 255 P ++ G+ V G PGT L D +A+ L AA Sbjct: 370 GFAPE-------LEALGIRTAVDDT-VLRVDGPCPPHRPGTDLRATDLRAAAVLLLAALA 421 Query: 256 KGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGD 291 G + + +G + L K+GA I Sbjct: 422 VPGRTTLRN-HHHLARGYRDLVEDLVKLGADIRHTT 456 Score = 31.6 bits (70), Expect = 0.63, Method: Composition-based stats. Identities = 64/368 (17%), Positives = 115/368 (31%), Gaps = 49/368 (13%) Query: 35 AHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLHAEGALELFLGN 94 A G + H+L+ + GV+ L+AD ++ + + N Sbjct: 126 ASGGCPIGEGPRGRPDEHLLDVMGRFGVTTRLTADG-SVDLTAQ-RLTPCTIDMLDYTRN 183 Query: 95 AGTAMRP-LAAALCLGSNDIVLTGEPRMKERP-----IGHLVDALRLGGAKITYLEQENY 148 P + A+ +T + P + +V LR GA I + E + Sbjct: 184 KALMSGPCYSGAVKTALLMGAVTHGTTTLQHPYLKPDVTDMVTVLRDLGADIEFAGPETW 243 Query: 149 PPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDITL--- 205 + G G + V + L+ ++ + ++ P ID + Sbjct: 244 V---IHGR---GPESLHRPVDVTLIPDLIEVVTWICAGVLLADEPLRITGPGIDRAVHAL 297 Query: 206 ----NLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVE--GDASSASYFLA--AAAIKG 257 +L+ GV ++ + P + G S + FLA A +G Sbjct: 298 APEFDLLDRMGVRVD-VGADEVTAHPLTKPLRPVEFTAMSRGVFSDSQPFLALLGAYAEG 356 Query: 258 GTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCT--------RGELNAIDMDMN 309 T + + FA LE +G D + +L A D+ Sbjct: 357 PTYIREAV----WEHRFGFAPELEALGIRTAVDDTVLRVDGPCPPHRPGTDLRATDLRAA 412 Query: 310 HIPDAAMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATELRKVGAEVEEGHDYIRIT 369 + AAL G TTLRN ++ D + +L K+GA++ + Sbjct: 413 A------VLLLAALAVPGRTTLRNHHHLARGYRD----LVEDLVKLGADIRHT-TAPDVR 461 Query: 370 PPEKLNFA 377 P Sbjct: 462 PKPPAGAG 469 >3T7C-A nrPDB Length = 299 Score = 31.6 bits (70), Expect = 0.72, Method: Composition-based stats. Identities = 26/100 (26%), Positives = 38/100 (38%), Gaps = 2/100 (2%) Query: 155 GGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDITLN--LMKTFG 212 GG G + S L L+ T L IR+ S + LN + F Sbjct: 180 GGLRGAENIGNYIASKHGLHGLMRTMALELGPRNIRVNIVCPSSVATPMLLNEPTYRMFR 239 Query: 213 VEIENQHYQQFVVKGGQSYQSPGTYLVEGDASSASYFLAA 252 ++EN + F V Q + P Y+ D S+A FL + Sbjct: 240 PDLENPTVEDFQVASRQMHVLPIPYVEPADISNAILFLVS 279 >5FAX-A nrPDB Length = 433 Score = 31.3 bits (69), Expect = 0.80, Method: Composition-based stats. Identities = 44/229 (19%), Positives = 72/229 (31%), Gaps = 22/229 (9%) Query: 31 LAALAHGKTVL---TNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLHAEGA 87 G+ V T L + M A ++ + RT NG H G+ Sbjct: 17 FGLYGQGQIVAVADTGLDTGRNDSSMHEAFRG-KITALYALGRTNNANDPNGHGTHVAGS 75 Query: 88 LELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGH--LVDALRLGGAKITYLEQ 145 + N G M P A + ++ + P L GA+I Sbjct: 76 VLGNATNKG--MAPQANLV----FQSIMDSGGGLGGLPANLQTLFSQAYSAGARIHTNSW 129 Query: 146 ENYPPLRLQGGFTGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDITL 205 + G +T + +VD V +T L P I G + + T Sbjct: 130 G----APVNGAYTTDSRNVDDYVRKNDMTILFAAGNEGPGSGTISAPGTAKNAITVGATE 185 Query: 206 NLMKTFGVEIEN-QHYQQFVVKGGQSYQSPGTYLVEGDASSASYFLAAA 253 NL +FG +N H QF +G ++ D + ++ +A Sbjct: 186 NLRPSFGSYADNINHVAQFSSRGPTR-----DGRIKPDVMAPGTYILSA 229 >3MK7-B nrPDB Length = 203 Score = 31.3 bits (69), Expect = 0.84, Method: Composition-based stats. Identities = 21/61 (34%), Positives = 25/61 (40%), Gaps = 2/61 (3%) Query: 41 LTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGP-LHAEGALELFLGNAGTAM 99 + N LD D ++AL LGV YT D NG + A A LG A T Sbjct: 144 VENTLDGKDTAKKMSALRMLGVPYT-EEDIAGARDSVNGKTEMDAMVAYLQVLGTALTNK 202 Query: 100 R 100 R Sbjct: 203 R 203 >5W1J-A nrPDB Length = 584 Score = 31.3 bits (69), Expect = 0.91, Method: Composition-based stats. Identities = 23/116 (19%), Positives = 37/116 (31%), Gaps = 18/116 (15%) Query: 215 IENQHYQQ----FVVKGGQSYQSPGTYLVEGDASSASYFLAAAAIKGG------------ 258 ++N + VV + P Y + GD S+A Y L AI+ G Sbjct: 396 LQNVDVKTTNGRVVVDDEERTNVPNIYAI-GDVSNAGYQLTPLAIQAGKNLARRLYTADD 454 Query: 259 -TVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGELNAIDMDMNHIPD 313 T + L + A +G+D I ++ + H PD Sbjct: 455 CRTDYTNVPTTVFTPLEYGCIGLSEENAISKFGEDNIEVFHSYFQPLEWTVPHRPD 510 >5IDU-A nrPDB Length = 410 Score = 30.5 bits (67), Expect = 1.3, Method: Composition-based stats. Identities = 57/337 (16%), Positives = 97/337 (28%), Gaps = 29/337 (8%) Query: 24 VSNRALLLAALAHGKTVLTNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLH 83 +R L A L + D + ALG + L + G+G + Sbjct: 28 ARHRELAAGIEAWATQHLACVQHDDTDTTCRKLVRALGEAGWLKYGVGGAQYGGHGDTID 87 Query: 84 AEGA--LELFLGNAGTAMRPLAAALCLGSNDIVLTGEPRMKERPIGHLVDALRLGGAKIT 141 L L N A LGS I L G K R + + + ++ Sbjct: 88 TRAVCLLRETLANHDGLADFALAMQGLGSGAITLAGTHEQKIRYLPRVSKGEAIAAFALS 147 Query: 142 YLEQE-NYPPLRLQGGFTGGNVDVDGS---VSSQFLTALLMT---APLAPEDTVIRIKGD 194 + + + LQ G +DG +S+ + + AP I Sbjct: 148 EPDAGSDVAAMSLQARAEGDCYVIDGDKTWISNGGIADFYVVFARTGEAPGARGISAFIV 207 Query: 195 LVSKPYIDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDASSASYFLAAAA 254 P + I + + H+ V Q +PG + + + AA Sbjct: 208 DADTPGLQIAERIDVIAPHPLARLHFDSARVPRSQMLGAPGEGFKIAMRTLDVFRTSVAA 267 Query: 255 IKGGTVKVTGIGRNSMQGDIRFADVLEKMGATICWGDDYISCTRGELNAIDMDMNHIPDA 314 G R ++Q + A + G L + + Sbjct: 268 AS------LGFARRALQEGLARAASRKMFG--------------QTLGDFQLTQTKLAQM 307 Query: 315 AMTIATAALFAKGTTTLRNIYNWRVKETDRLFAMATE 351 A+TI ++AL LR+ +E A+E Sbjct: 308 ALTIDSSALLVYRAAWLRDQGENVTREAAMAKWHASE 344 >2RF1-A nrPDB Length = 298 Score = 30.5 bits (67), Expect = 1.4, Method: Composition-based stats. Identities = 32/167 (19%), Positives = 53/167 (31%), Gaps = 23/167 (13%) Query: 258 GTVKVTGIG-RNSMQGDIRFADVLEKMGATICWGDDYISCTRGELNAIDMD---MNHIPD 313 GTV+ + +G + +LE +G + T L D+D N +P Sbjct: 7 GTVRFSDVGWTDITATTATATTILEALGYETDVKVLSVPVTYTSLKNKDIDVFLGNWMPT 66 Query: 314 AAMTIATAALFAKGTTTLRNIY-------------NWRVKETDRLFAMATELRKVGAEVE 360 IA T N+ +K+ + A EL +E Sbjct: 67 MEADIAPYREDKSVETVRENLAGAKYTLATNAKGAELGIKDFKDIAAHKDELDGKIYGIE 126 Query: 361 EGHDY--IRITPPEK----LNFAEIATYNDHRMAMCFSLVALSDTPV 401 G+D + I EK L E+ ++ M + S P+ Sbjct: 127 PGNDGNRLIIDMVEKGTFDLKGFEVVESSEQGMLAQVARAEKSGDPI 173 >3U0A-A nrPDB Length = 285 Score = 29.3 bits (64), Expect = 3.1, Method: Composition-based stats. Identities = 24/90 (26%), Positives = 36/90 (40%), Gaps = 9/90 (10%) Query: 209 KTFGVEIENQHYQQFVVKGGQSYQSP---GTYLVEGDASSASYFLAAAAIKGGTVKVTGI 265 +TFG + Q V YQ G +L GDA + FL GG+ + Sbjct: 35 RTFGGHVAGQSLVSAVRTVDPRYQVHSLHGYFLRSGDAQEPTVFLVERTRDGGSFVTRRV 94 Query: 266 GRNSMQGDIRFADVLEKMGATICWGDDYIS 295 N++Q +V+ MGA+ + IS Sbjct: 95 --NAVQHG----EVIFSMGASFQTAQNGIS 118 >3IAW-A nrPDB Length = 203 Score = 28.9 bits (63), Expect = 4.2, Method: Composition-based stats. Identities = 28/112 (25%), Positives = 41/112 (36%), Gaps = 7/112 (6%) Query: 55 NALTALGVSYTLSA-DRTRCEIIGN---GGPLHAEGALELFLGNAGTAMRPLAAALCLGS 110 + +G + D+ EI G+ G L + + N T + G Sbjct: 45 KLIGGIGGFIKVRQYDQIPVEIAGHKAIGTVLVGPTPVNIIGRNLLTQIGATLNFCGGGG 104 Query: 111 NDIVLTGEPRMKERPIGHLVDALRLGGAKITYLEQENYP---PLRLQGGFTG 159 I L P + R G L +AL GA T +E+ N P +L GG G Sbjct: 105 PQITLWKRPLVTIRIGGQLKEALLDTGADDTVIEELNLPGCWKPKLIGGIAG 156 >3QS3-A nrPDB Length = 191 Score = 28.9 bits (63), Expect = 4.3, Method: Composition-based stats. Identities = 21/116 (18%), Positives = 40/116 (34%), Gaps = 3/116 (2%) Query: 225 VKGGQSYQSPGTYLVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMG 284 +KG S + +EGD+++ ++ L + I ++ G G +EK G Sbjct: 36 IKGFNSQKGLFDVAIEGDSTATAFKLTSRLITNTLTQLDTSGSTLNVGVDYNGTAVEKTG 95 Query: 285 AT--ICWGDDYISCTRGEL-NAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNW 337 T I + + L N + T + + GTT + + Sbjct: 96 DTVMIDTANGVLGGNLSPLANGYNASNRTTAQDGFTFSIISGTTNGTTAVTDYSTL 151 >3QS2-A nrPDB Length = 188 Score = 28.6 bits (62), Expect = 5.5, Method: Composition-based stats. Identities = 21/116 (18%), Positives = 40/116 (34%), Gaps = 3/116 (2%) Query: 225 VKGGQSYQSPGTYLVEGDASSASYFLAAAAIKGGTVKVTGIGRNSMQGDIRFADVLEKMG 284 +KG S + +EGD+++ ++ L + I ++ G G +EK G Sbjct: 54 IKGFNSQKGLFDVAIEGDSTATAFKLTSRLITNTLTQLDTSGSTLNVGVDYNGTAVEKTG 113 Query: 285 AT--ICWGDDYISCTRGEL-NAIDMDMNHIPDAAMTIATAALFAKGTTTLRNIYNW 337 T I + + L N + T + + GTT + + Sbjct: 114 DTVMIDTANGVLGGNLSPLANGYNASNRTTAQDGFTFSIISGTTNGTTAVTDYSTL 169 >1J7H-A nrPDB Length = 130 Score = 28.6 bits (62), Expect = 6.0, Method: Composition-based stats. Identities = 12/81 (14%), Positives = 24/81 (29%), Gaps = 11/81 (13%) Query: 201 IDITLNLMKTFGVEIENQHYQQFVVKGGQSYQSPGTYLVEGDASSASYFLAAAAIKGGTV 260 I T G ++ V+ GQ +P T V D + Sbjct: 5 IIHTEKAPAAIGPYVQAVDLGNLVLTSGQIPVNPATGEVPADI-----------VAQARQ 53 Query: 261 KVTGIGRNSMQGDIRFADVLE 281 + + + + AD+++ Sbjct: 54 SLENVKAIIEKAGLTAADIVK 74 >5XNX-A nrPDB Length = 394 Score = 28.2 bits (61), Expect = 7.5, Method: Composition-based stats. Identities = 16/93 (17%), Positives = 25/93 (26%), Gaps = 3/93 (3%) Query: 10 ARVDGTINLPGSKSVSNRALLLAALAH---GKTVLTNLLDSDDVRHMLNALTALGVSYTL 66 R + G +++ + LA T L L D V L AL + Sbjct: 40 QRHASQLRQSGDPYITHPLAVANILAELGMDTTTLVAALLHDTVEDTGYTLEALTEEFGE 99 Query: 67 SADRTRCEIIGNGGPLHAEGALELFLGNAGTAM 99 + + A + TAM Sbjct: 100 EVGHLVDGVTKLDRVVLGSAAEGETIRKMITAM 132 >1WMD-A nrPDB Length = 434 Score = 27.8 bits (60), Expect = 9.7, Method: Composition-based stats. Identities = 45/217 (20%), Positives = 71/217 (32%), Gaps = 22/217 (10%) Query: 42 TNLLDSDDVRHMLNALTALGVSYTLSADRTRCEIIGNGGPLHAEGALELFLGNAGT--AM 99 T L + M A ++ + RT NG H G+ LGN T M Sbjct: 31 TGLDTGRNDSSMHEAFRG-KITALYALGRTNNANDTNGHGTHVAGS---VLGNGSTNKGM 86 Query: 100 RPLAAALCLGSNDIVLTGEPRMKERP--IGHLVDALRLGGAKITYLEQENYPPLRLQGGF 157 P A + ++ + P + L GA+I + G + Sbjct: 87 APQANLV----FQSIMDSGGGLGGLPSNLQTLFSQAYSAGARIHTNSWG----AAVNGAY 138 Query: 158 TGGNVDVDGSVSSQFLTALLMTAPLAPEDTVIRIKGDLVSKPYIDITLNLMKTFGVEIEN 217 T + +VD V +T L P I G + + T NL +FG +N Sbjct: 139 TTDSRNVDDYVRKNDMTILFAAGNEGPNGGTISAPGTAKNAITVGATENLRPSFGSYADN 198 Query: 218 -QHYQQFVVKGGQSYQSPGTYLVEGDASSASYFLAAA 253 H QF +G ++ D + F+ +A Sbjct: 199 INHVAQFSSRGPTK-----DGRIKPDVMAPGTFILSA 230 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.309 0.128 0.297 Lambda K H 0.267 0.0392 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,244,951 Number of Sequences: 36641 Number of extensions: 473954 Number of successful extensions: 1753 Number of sequences better than 10.0: 46 Number of HSP's better than 10.0 without gapping: 51 Number of HSP's successfully gapped in prelim test: 35 Number of HSP's that attempted gapping in prelim test: 1396 Number of HSP's gapped (non-prelim): 125 length of query: 427 length of database: 10,336,785 effective HSP length: 100 effective length of query: 327 effective length of database: 6,672,685 effective search space: 2181967995 effective search space used: 2181967995 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 60 (27.8 bits)