BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P09950 (548 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5TXT-B nrPDB 1027 0.0 6HRH-B nrPDB 392 e-109 2BWN-A nrPDB 382 e-106 3TQX-A nrPDB 216 1e-56 1FC4-A nrPDB 207 9e-54 4BMK-A nrPDB 155 6e-38 6ONN-A nrPDB 145 4e-35 5JAY-A nrPDB 144 8e-35 3A2B-A nrPDB 142 3e-34 2X8U-A nrPDB 140 2e-33 4IW7-A nrPDB 127 1e-29 1DJ9-A nrPDB 117 1e-26 3WY7-A nrPDB 117 1e-26 5VNX-A nrPDB 104 1e-22 3HQT-A nrPDB 92 5e-19 2CFB-A nrPDB 40 0.002 3VK2-A nrPDB 40 0.002 4OC9-A nrPDB 35 0.068 5VMB-A nrPDB 35 0.094 1N8P-A nrPDB 35 0.10 1CS1-A nrPDB 35 0.11 1GDE-A nrPDB 33 0.23 4P3M-A nrPDB 33 0.41 4E77-A nrPDB 33 0.43 3THY-A nrPDB 33 0.47 4RCT-A nrPDB 32 0.64 1IBJ-A nrPDB 32 0.95 3MKJ-A nrPDB 31 1.1 3N0L-A nrPDB 30 2.1 3GBX-A nrPDB 30 2.3 3G8M-A nrPDB 30 2.5 4BWG-A nrPDB 30 2.8 6A2F-A nrPDB 30 3.0 3FDB-A nrPDB 30 3.2 5XT5-A nrPDB 29 6.4 4AD9-A nrPDB 29 6.7 1E5F-A nrPDB 28 7.7 >5TXT-B nrPDB Length = 491 Score = 1027 bits (2655), Expect = 0.0, Method: Compositional matrix adjust. Identities = 491/491 (100%), Positives = 491/491 (100%) Query: 58 AAAAANHSTQESGFDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTV 117 AAAAANHSTQESGFDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTV Sbjct: 1 AAAAANHSTQESGFDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTV 60 Query: 118 WCSNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGAL 177 WCSNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGAL Sbjct: 61 WCSNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGAL 120 Query: 178 VFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQL 237 VFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQL Sbjct: 121 VFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQL 180 Query: 238 LQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVA 297 LQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVA Sbjct: 181 LQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVA 240 Query: 298 EHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFR 357 EHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFR Sbjct: 241 EHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFR 300 Query: 358 SFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPS 417 SFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPS Sbjct: 301 SFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPS 360 Query: 418 HIVPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILI 477 HIVPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILI Sbjct: 361 HIVPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILI 420 Query: 478 NAVDDVFNELQLPRVRDWESQGGLLGVGESGFVEESNLWTSSQLSLTNDDLNPNVRDPIV 537 NAVDDVFNELQLPRVRDWESQGGLLGVGESGFVEESNLWTSSQLSLTNDDLNPNVRDPIV Sbjct: 421 NAVDDVFNELQLPRVRDWESQGGLLGVGESGFVEESNLWTSSQLSLTNDDLNPNVRDPIV 480 Query: 538 KQLEVSSGIKQ 548 KQLEVSSGIKQ Sbjct: 481 KQLEVSSGIKQ 491 >6HRH-B nrPDB Length = 469 Score = 392 bits (1007), Expect = e-109, Method: Compositional matrix adjust. Identities = 187/429 (43%), Positives = 282/429 (65%), Gaps = 28/429 (6%) Query: 68 ESGFDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREAD----KVTVWCSNDY 123 +S F Y+ ++ +K+ D +YR F +NR A +P A EA V+VWCSNDY Sbjct: 22 QSMFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDY 81 Query: 124 LALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCY 183 L +S+HP+VL A +T+ ++G GAGGTRNI+G + + LE ELA LH+K+ AL+FSSC+ Sbjct: 82 LGMSRHPQVLQATQETLQRHGVGAGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCF 141 Query: 184 VANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPK 243 VAND+ L L + + I+SD NHASMI GI+++ K +F+HND + L++LL+ Sbjct: 142 VANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKSNP 201 Query: 244 SVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFE 303 +PK++AFE+V+SM G++ +E++CD++ +YGALTF+DEVHAVGLYG GAG+ E Sbjct: 202 KIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIGER---- 257 Query: 304 SHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGF 363 +M ++D+I+GTLGK+FG VGGY+A++R L+D RS+A GF Sbjct: 258 ------------------DGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGF 299 Query: 364 IFTTTLPPSVMAGATAAIRYQRCHID--LRTSQQKHTMYVKKAFHELGIPVIPNPSHIVP 421 IFTT+LPP V++GA ++R + LR + Q++ ++++ + G+PVIP PSHI+P Sbjct: 300 IFTTSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIP 359 Query: 422 VLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVD 481 + +GNA L + D+L++KH IYVQAIN+PTV RG E LR+ P+P H+ + + + + Sbjct: 360 IRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLL 419 Query: 482 DVFNELQLP 490 + + LP Sbjct: 420 LAWTAVGLP 428 >2BWN-A nrPDB Length = 401 Score = 382 bits (980), Expect = e-106, Method: Compositional matrix adjust. Identities = 199/416 (47%), Positives = 263/416 (63%), Gaps = 27/416 (6%) Query: 71 FDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQRE---ADKVTVWCSNDYLALS 127 DY +D +QK + YR F +I R FP A R +TVWC NDYL + Sbjct: 1 MDYNLALDKAIQKLHDEGRYRTFIDIEREKGAFPKAQWNRPDGGKQDITVWCGNDYLGMG 60 Query: 128 KHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVAND 187 +HP VL AMH+ ++ G G+GGTRNI+G LEAE+A LH+KE ALVFSS Y AND Sbjct: 61 QHPVVLAAMHEALEAVGAGSGGTRNISGTTAYHRRLEAEIAGLHQKEAALVFSSAYNAND 120 Query: 188 AVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPK 247 A LS L L+I+SD LNHASMI GIK K IF+HND+ L +L+ + + PK Sbjct: 121 ATLSTLRVLFPGLIIYSDSLNHASMIEGIKRNAGPKRIFRHNDVAHLRELIAADDPAAPK 180 Query: 248 LIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRA 307 LIAFESVYSM G I++ICD+A+++GALT++DEVHAVG+YGP GAGVAE Sbjct: 181 LIAFESVYSMDGDFGPIKEICDIAEEFGALTYIDEVHAVGMYGPRGAGVAER-------- 232 Query: 308 SGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTT 367 +M R+D+ GTL K++G GGY+AAS +++D RS+APGFIF+T Sbjct: 233 --------------DGLMHRIDIFNGTLAKAYGVFGGYIAASARMVDAVRSYAPGFIFST 278 Query: 368 TLPPSVMAGATAAIRYQRCH--IDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIVPVLIG 425 +LPP++ AGA A+I + + LR +QQ H +K LG+P+I + SHIVPV+IG Sbjct: 279 SLPPAIAAGAQASIAFLKTAEGQKLRDAQQMHAKVLKMRLKALGMPIIDHGSHIVPVVIG 338 Query: 426 NADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVD 481 + K SD+L++ + +YVQ INFPTV RGTERLR TP+P H D L++A+D Sbjct: 339 DPVHTKAVSDMLLSDYGVYVQPINFPTVPRGTERLRFTPSPVHDLKQIDGLVHAMD 394 >3TQX-A nrPDB Length = 399 Score = 216 bits (551), Expect = 1e-56, Method: Compositional matrix adjust. Identities = 124/379 (32%), Positives = 204/379 (53%), Gaps = 31/379 (8%) Query: 114 KVTVWCSNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKK 173 +V +C+N+YL L+ HP ++ +++YG G R I G LE +++ Sbjct: 44 EVLNFCANNYLGLADHPALIKTAQTVVEQYGFGMASVRFICGTQTIHKELEKDISEFLGT 103 Query: 174 EGALVFSSCYVANDAVL-SLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLN 232 + +++SSC+ AN + +LLG + I SDELNHAS+I GI+ +++ +K+N + Sbjct: 104 DDTILYSSCFDANGGLFETLLG---PEDAIISDELNHASIIDGIRLCKAQRYRYKNNAMG 160 Query: 233 ELEQLLQSYPKSVP--KLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYG 290 +LE L+ + KLIA + V+SM G +AD++ ICDLADKY AL +D+ HAVG G Sbjct: 161 DLEAKLKEADEKGARFKLIATDGVFSMDGIIADLKSICDLADKYNALVMVDDSHAVGFIG 220 Query: 291 PHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSV-GGYVAAS 349 +G G E+C V DRVD++TGTLGK+ G GGY + Sbjct: 221 ENGRGTPEYCG----------------------VADRVDILTGTLGKALGGASGGYTSGH 258 Query: 350 RKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCH-IDLRTSQQKHTMYVKKAFHEL 408 +++I+W R+ + ++F+ T+ P ++A + + + LR Q+++ Y + +L Sbjct: 259 KEIIEWLRNRSRPYLFSNTVAPVIVATSLKVLELLKTEGPQLRKQLQENSRYFRAGMEKL 318 Query: 409 GIPVIPNPSHIVPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGH 468 G ++P I+PV++G+A LA +D L+ + IYV ++P V G R+R+ + H Sbjct: 319 GFQLVPGNHPIIPVMLGDAQLATNMADHLL-QEGIYVVGFSYPVVPMGKARIRVQMSAVH 377 Query: 469 TNDLSDILINAVDDVFNEL 487 T D I A V +L Sbjct: 378 TQQQLDRAIEAFGQVGKKL 396 >1FC4-A nrPDB Length = 401 Score = 207 bits (527), Expect = 9e-54, Method: Compositional matrix adjust. Identities = 119/359 (33%), Positives = 193/359 (53%), Gaps = 30/359 (8%) Query: 115 VTVWCSNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKE 174 V +C+N+YL L+ HP+++ A +D +G G R I G LE +LA E Sbjct: 47 VINFCANNYLGLANHPDLIAAAKAGMDSHGFGMASVRFICGTQDSHKELEQKLAAFLGME 106 Query: 175 GALVFSSCYVANDAVL-SLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNE 233 A+++SSC+ AN + +LLG + I SD LNHAS+I G++ K++ + +ND+ E Sbjct: 107 DAILYSSCFDANGGLFETLLG---AEDAIISDALNHASIIDGVRLCKAKRYRYANNDMQE 163 Query: 234 LEQLLQSYPKSVPK--LIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGP 291 LE L+ ++ + LIA + V+SM G +A+++ +CDLADKY AL +D+ HAVG G Sbjct: 164 LEARLKEAREAGARHVLIATDGVFSMDGVIANLKGVCDLADKYDALVMVDDSHAVGFVGE 223 Query: 292 HGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSV-GGYVAASR 350 +G G E+CD VM RVD+ITGTLGK+ G GGY AA + Sbjct: 224 NGRGSHEYCD----------------------VMGRVDIITGTLGKALGGASGGYTAARK 261 Query: 351 KLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGI 410 ++++W R + ++F+ +L P+++A + + +LR + ++ G Sbjct: 262 EVVEWLRQRSRPYLFSNSLAPAIVAASIKVLEMVEAGSELRDRLWANARQFREQMSAAGF 321 Query: 411 PVIPNPSHIVPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHT 469 + I+PV++G+A +A++ + L K IYV +P V +G R+R + HT Sbjct: 322 TLAGADHAIIPVMLGDAVVAQKFAREL-QKEGIYVTGFFYPVVPKGQARIRTQMSAAHT 379 >4BMK-A nrPDB Length = 442 Score = 155 bits (391), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 118/430 (27%), Positives = 202/430 (46%), Gaps = 40/430 (9%) Query: 52 THAAAAAAAAANHSTQESGFD----------YEGLIDSELQKKRLDKSYRYFNNINRLAK 101 +H A+ AAA H+ D ++GLI ++K LD I Sbjct: 18 SHMASTEAAAQPHALPADAPDIAPERDLLSKFDGLIAE--RQKLLDSGVTDPFAIVMEQV 75 Query: 102 EFPLAHRQREADKVTVWCSNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTL 161 + P R D + + N Y+ ++ P+V+ A + ++K+G G G+R + G + Sbjct: 76 KSPTEAVIRGKDTILLGTYN-YMGMTFDPDVIAAGKEALEKFGSGTNGSRMLNGTFHDHM 134 Query: 162 NLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANV 221 +E L + GA+VFS+ Y+AN ++S L K + +++ +D +HAS+ G + N Sbjct: 135 EVEQALRDFYGTTGAIVFSTGYMANLGIISTLAGKGEYVILDAD--SHASIYDGCQQGNA 192 Query: 222 KKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLD 281 + F+HN + +L++ L PK KL+ E VYSM G +A ++++ +A K+GA+ +D Sbjct: 193 EIVRFRHNSVEDLDKRLGRLPKEPAKLVVLEGVYSMLGDIAPLKEMVAVAKKHGAMVLVD 252 Query: 282 EVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGS 341 E H++G +GP+G GV E A+ + ++D + GT S G+ Sbjct: 253 EAHSMGFFGPNGRGVYE----------------------AQGLEGQIDFVVGTFSASVGT 290 Query: 342 VGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYV 401 VGG+V ++ + R +IFT +LPPSV+A AT +IR + R + + Sbjct: 291 VGGFVVSNHPKFEAVRLACRPYIFTASLPPSVVATATTSIRKLMTAHEKRERLWSNARAL 350 Query: 402 KKAFHELGIPVIPNP--SHIVPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTER 459 +G + S IV V++ + + A L++ +YV P GT Sbjct: 351 HGGLKAMGFRLGTETCDSAIVAVMLEDQEQAAMMWQALLDG-GLYVNMARPPATPAGTFL 409 Query: 460 LRITPTPGHT 469 LR + HT Sbjct: 410 LRCSICAEHT 419 >6ONN-A nrPDB Length = 402 Score = 145 bits (366), Expect = 4e-35, Method: Compositional matrix adjust. Identities = 121/388 (31%), Positives = 193/388 (49%), Gaps = 55/388 (14%) Query: 106 AHRQREADKVTVWCSNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEA 165 AH + + + SNDYL L+ HP ++ A+ + +YG G+GG+ + GH+ LE Sbjct: 40 AHMTVDGRNMIGFASNDYLGLAAHPLLVAAITEGARRYGAGSGGSHLLGGHSRAHAQLED 99 Query: 166 ELATLH----KKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANV 221 +LA AL FS+ Y+AN A L+ L + L FSD LNHAS+I G + + Sbjct: 100 DLAEFAGGFVDNPRALYFSTGYMANLATLTALAGRGTTL--FSDSLNHASLIDGARLSRA 157 Query: 222 KKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLD 281 I+ H D L +L++ +V KLI ++V+SM G +A + ++ +LA+ +GA +D Sbjct: 158 DIQIYPHADAEALGAMLEASDAAV-KLIVSDTVFSMDGDIAPLARLLELAEHHGAWLVVD 216 Query: 282 EVHAVGLYGPHGAG-VAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFG 340 + H G+ GP G G VAE + + +P ++ GTLGK+ G Sbjct: 217 DAHGFGVLGPQGRGAVAE---------AALRSPHL--------------IVVGTLGKAAG 253 Query: 341 SVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIR--------YQRCHIDLRT 392 G +V A +I+W A +IFTT PS +A++R ++R H+ Sbjct: 254 VSGAFVVAHETVIEWLVQRARPYIFTTASVPSAAHAVSASLRIIGGDEGEHRRAHLRSLI 313 Query: 393 SQQKHTMYVKKAFHELGIPVIPNPSH--IVPVLIGN--ADLAKQASDILINKHQIYVQAI 448 + + + P +P SH + P++IG+ A L AS +++ ++V AI Sbjct: 314 ALTRDMLK--------STPWLPVDSHTAVQPLIIGSNEATLDVAAS---LDRANLWVPAI 362 Query: 449 NFPTVARGTERLRITPTPGHT-NDLSDI 475 PTV GT RLRI+ + H+ NDL + Sbjct: 363 RPPTVPEGTSRLRISLSAAHSHNDLEQL 390 >5JAY-A nrPDB Length = 402 Score = 144 bits (364), Expect = 8e-35, Method: Compositional matrix adjust. Identities = 113/372 (30%), Positives = 183/372 (49%), Gaps = 34/372 (9%) Query: 106 AHRQREADKVTVWCSNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEA 165 AH + + + SNDYL L+ HP+++ A+ + +YG G+GG+ + GH+ LE Sbjct: 40 AHMTVDGRAIIGFASNDYLGLAAHPQLIAAIAEGAQRYGAGSGGSHLLGGHSRAHAQLED 99 Query: 166 ELAT----LHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANV 221 +LA + AL FS+ Y+AN A L+ L + L FSD LNHAS+I G + + Sbjct: 100 DLAEFVGGFVENARALYFSTGYMANLATLTALAGRGTTL--FSDALNHASLIDGARLSRA 157 Query: 222 KKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLD 281 I+ H D + L +L++ V K+I ++V+SM G +A + ++ +LA+++GA +D Sbjct: 158 DVQIYPHCDTDALSAMLEASDADV-KVIVSDTVFSMDGDIAPLPRLLELAEQHGAWLIVD 216 Query: 282 EVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGS 341 + H G+ GP G G S I GTL K+ G Sbjct: 217 DAHGFGVLGPQGRGAIAQAALRSPNLISI----------------------GTLDKAAGV 254 Query: 342 VGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHI-DLRTSQQKHTMY 400 G +VAA +I+W A +IFTT P+ +A++R D R + + + Sbjct: 255 SGAFVAAHETVIEWLVQRARPYIFTTASVPAAAHAVSASLRIIGGEEGDARRAHLQQLIG 314 Query: 401 VKKAFHELGIPVIPNPSH--IVPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTE 458 +A + P +P SH + P++IG D + + L ++ ++V AI PTV GT Sbjct: 315 RTRAMLK-ATPWLPVDSHTAVQPLIIGANDATLEIAATL-DRAGLWVPAIRPPTVPTGTS 372 Query: 459 RLRITPTPGHTN 470 RLRI+ + H+ Sbjct: 373 RLRISLSAAHSQ 384 >3A2B-A nrPDB Length = 398 Score = 142 bits (359), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 110/415 (26%), Positives = 194/415 (46%), Gaps = 36/415 (8%) Query: 77 IDSELQKKRLDKSYRYFNNI-NRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPEVLDA 135 I EL+ K L Y YF I ++ E + R +V ++ SN YL L+ ++ A Sbjct: 14 IVEELKAKGL---YAYFRPIQSKQDTEVKIDGR-----RVLMFGSNSYLGLTTDTRIIKA 65 Query: 136 MHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLS-LLG 194 ++KYG G G+R + G + LE +L+ KE A++FS+ + +N LS L+G Sbjct: 66 AQDALEKYGTGCAGSRFLNGTLDIHVELEEKLSAYVGKEAAILFSTGFQSNLGPLSCLMG 125 Query: 195 QKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESV 254 ++ I DE +HAS+I G + + K + HN++ +L L P+ KLI + + Sbjct: 126 ---RNDYILLDERDHASIIDGSRLSFSKVIKYGHNNMEDLRAKLSRLPEDSAKLICTDGI 182 Query: 255 YSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPK 314 +SM G + ++ ++ +A+++ A +D+ H++G+ G GAG A H Sbjct: 183 FSMEGDIVNLPELTSIANEFDAAVMVDDAHSLGVIGHKGAGTASHFGLN----------- 231 Query: 315 TNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVM 374 D VD+I GT KS S+GG+VA +ID+ + A +F+ ++ P+ + Sbjct: 232 -----------DDVDLIMGTFSKSLASLGGFVAGDADVIDFLKHNARSVMFSASMTPASV 280 Query: 375 AGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIVPVLIGNADLAKQAS 434 A A+ + + K+T Y K + G + S I+P+ I + + + Sbjct: 281 ASTLKALEIIQNEPEHIEKLWKNTDYAKAQLLDHGFDLGATESPILPIFIRSNEKTFWVT 340 Query: 435 DILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVDDVFNELQL 489 +L ++V + P V +R + HT D D I + VF + ++ Sbjct: 341 KML-QDDGVFVNPVVSPAVPAEESLIRFSLMATHTYDQIDEAIEKMVKVFKQAEV 394 >2X8U-A nrPDB Length = 412 Score = 140 bits (352), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 95/360 (26%), Positives = 171/360 (47%), Gaps = 27/360 (7%) Query: 114 KVTVWCSNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKK 173 K + + +Y+ ++ P+V+ A + +D++G G G+R + G E L + Sbjct: 45 KTILLGTYNYMGMTFDPDVIAAGKQALDEFGSGTTGSRVLNGTYQGHKACEDALKEFYGT 104 Query: 174 EGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNE 233 E A+VFS+ Y AN ++S L K +++ +D +HAS+ G + + F+HN + + Sbjct: 105 EHAIVFSTGYQANLGMISTLAGKGDYIILDAD--SHASIYDGCWLGDAEIVRFRHNSVED 162 Query: 234 LEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHG 293 L++ L P KL+ E VYSM G +A ++++ ++ K+GA+ +DE H +G +G HG Sbjct: 163 LDKRLGRLPAEAGKLVVLEGVYSMMGDIAPLQEMVAVSKKHGAMILVDEAHGMGFFGEHG 222 Query: 294 AGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLI 353 GV E E+ VD + GT KS G+VGG+ ++ Sbjct: 223 RGVFEEAGVEAD----------------------VDFVVGTFSKSVGTVGGFCVSNHPKF 260 Query: 354 DWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVI 413 + R ++FT +LPPSV+A A +IR D R K++ + + ++G + Sbjct: 261 EVLRLVCRPYVFTASLPPSVVATAATSIRKLMHAGDKRAHLWKNSRRLHQGLRDMGYKLG 320 Query: 414 PNPSHIVPVLIGNADLAKQASDIL--INKHQIYVQAINFPTVARGTERLRITPTPGHTND 471 + + + D+A QA + + + +YV P G LR + H+++ Sbjct: 321 TETAQSAIIAVILTDMA-QAVALWQGLLEAGLYVNTARPPATPAGMFLLRCSLCAEHSDE 379 >4IW7-A nrPDB Length = 399 Score = 127 bits (319), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 101/382 (26%), Positives = 177/382 (46%), Gaps = 36/382 (9%) Query: 113 DKVTVWCSNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHK 172 D + + ++DYL LS + A+ DKYG G+ G+ + G+ T E E A Sbjct: 51 DSIIDFTTSDYLNLSSAHNLKHAIVNGFDKYGFGSKGSNIVCGYTDETQQFEHEFAKFIN 110 Query: 173 KEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLN 232 A+ FSS ++AN A+ S L K IF+D+ HAS+I GIK + K +KH L+ Sbjct: 111 YPRAIFFSSGFMANLAIYSTLFSKHDS--IFADKYIHASIIDGIKLSQAKLRRYKHQQLS 168 Query: 233 ELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPH 292 +L+ + I E V+S +GS+ ++K+ + + +DE H+ G+ G + Sbjct: 169 QLQDIYDG-----KSFITTEGVFSTSGSITQLDKLAKITPEK---LIVDEAHSFGVLGKN 220 Query: 293 GAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKL 352 G G I + + + K V LGK+FG VG V + + Sbjct: 221 GRG-------------AINSFRISYKNCLICVF--------PLGKAFGGVGAVVCTTEAI 259 Query: 353 IDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPV 412 ++ FA +I+TT LPP ++ A ++ D R Q++ + + + + Sbjct: 260 AEYLIQFARNYIYTTALPPMILKAALIQLKNLENVNDNRARLQQNITFFNELCDAKDLEL 319 Query: 413 I-PNPSHIVPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTND 471 + + S I + + NA+LA + D L +++I V +PTV + LR + H+N+ Sbjct: 320 VSKDLSPIRSIQLNNANLAIRLKDKLF-ENKIIVSCFRYPTVPKDQAILRFSL---HSNN 375 Query: 472 LSDILINAVDDVFNELQLPRVR 493 D + A++ + E++ +R Sbjct: 376 TFDQIQQALEIISKEVKYEYIR 397 >1DJ9-A nrPDB Length = 384 Score = 117 bits (294), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 99/358 (27%), Positives = 171/358 (47%), Gaps = 32/358 (8%) Query: 120 SNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVF 179 SNDYL LS HP+++ A + +++G G+GG+ +++G+++ LE ELA AL+F Sbjct: 46 SNDYLGLSHHPQIIRAWQQGAEQFGIGSGGSGHVSGYSVVHQALEEELAEWLGYSRALLF 105 Query: 180 SSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQ 239 S + AN AV++ + K+ I +D L+HAS++ + + F HND+ L +LL Sbjct: 106 ISGFAANQAVIAAM--MAKEDRIAADRLSHASLLEAASLSPSQLRRFAHNDVTHLARLLA 163 Query: 240 SYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEH 299 S P +++ E V+SM G A + +I + ++ +D+ H G+ G G G Sbjct: 164 S-PCPGQQMVVTEGVFSMDGDSAPLAEIQQVTQQHNGWLMVDDAHGTGVIGEQGRG---S 219 Query: 300 CDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSF 359 C + + +++ T GK FG G V S + D+ F Sbjct: 220 CWLQKVKP---------------------ELLVVTFGKGFGVSGAAVLCSSTVADYLLQF 258 Query: 360 APGFIFTTTLPPSVMAGATAAIRYQRC-HIDLRTSQQKHTM-YVKKAFHELGIPVIPNPS 417 A I++T++PP+ A++ R D R + + + +L + + S Sbjct: 259 ARHLIYSTSMPPAQAQALRASLAVIRSDEGDARREKLAALITRFRAGVQDLPFTLADSCS 318 Query: 418 HIVPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDI 475 I P+++G+ A Q ++ L + +V I PTV G RLR+T T H ++ DI Sbjct: 319 AIQPLIVGDNSRALQLAEKL-RQQGCWVTGIRPPTVPAGIARLRLTLTAAH--EMQDI 373 >3WY7-A nrPDB Length = 404 Score = 117 bits (294), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 125/413 (30%), Positives = 193/413 (46%), Gaps = 64/413 (15%) Query: 82 QKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPEVLDAMHKTID 141 Q++R + R +A E LA SNDYL LS+HP+VLD + + Sbjct: 39 QRRRAEGLRRELRVRPPVAAELDLA-------------SNDYLGLSQHPDVLDGGVEALR 85 Query: 142 KYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVAN-DAVLSLLGQKMKDL 200 +G GAGG+R + G+ E +LA+ E ALVFSS Y AN A+++L G Sbjct: 86 TWGGGAGGSRLVTGNTELHEAFEHQLASFLGAESALVFSSGYTANLGALVALSGPGS--- 142 Query: 201 VIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGS 260 +I SD L+HAS++ + + + + H D++ ++ L + + ++ ESV+S G Sbjct: 143 LIVSDALSHASLVDACRLSRARVVVSPHRDVDAVDAALAARTEE-RAVVVTESVFSADGD 201 Query: 261 VADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGG 320 +A + + + ++GAL +DE H +G+ G G G+ G+A G Sbjct: 202 LAPLRDLHAVCRRHGALLLVDEAHGLGVRGTRGQGLLHEV--------GLA-------GA 246 Query: 321 AKTVMDRVDMITGTLGKSFGSVGGYV----AASRKLIDWFRSFAPGFIFTTTLPPSVMAG 376 VM T TL K+ GS GG V A LID RS FIF T L P+ + Sbjct: 247 PDIVM------TTTLSKALGSQGGAVLGPEAVRAHLIDTARS----FIFDTGLAPAAVGA 296 Query: 377 ATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIP-VIPNP-SHIVPVLIGNADLAKQAS 434 A+AA+R L Q+ + +A I V P S +V V++G+ ++A A+ Sbjct: 297 ASAALRV------LDAEPQRARAVLDRAAELATIAGVTEAPVSAVVSVILGDPEIAVGAA 350 Query: 435 DILINKHQIYVQAINFPTVARGTERLRITPTPGHTND--------LSDILINA 479 +++ + V PTV GT RLR+ T+D L+D+L A Sbjct: 351 AACLDR-GVRVGCFRPPTVPAGTSRLRLAARASLTDDEMALARQVLTDVLATA 402 >5VNX-A nrPDB Length = 393 Score = 104 bits (259), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 124/404 (30%), Positives = 195/404 (48%), Gaps = 37/404 (9%) Query: 76 LIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPEVLDA 135 L+D+ LQ+ D + + R A AH ++ + SNDYL L+ HP+++ A Sbjct: 3 LLDT-LQRGLADLDAQGLRRVRRTADSACDAHMTVNGREIVGFASNDYLGLAAHPKLVAA 61 Query: 136 MHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELA----TLHKKEGALVFSSCYVANDAVLS 191 + +YG G+GG+ + GH+ LE ELA AL FS+ Y+AN A ++ Sbjct: 62 FAEGAQRYGSGSGGSHLLGGHSRAHAKLEDELAGFAGGFSDAPRALYFSTGYMANLAAVT 121 Query: 192 LLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAF 251 L KD IFSD LNHAS+I G + + ++ H D L LL++ S KLI Sbjct: 122 ALAG--KDATIFSDALNHASLIDGTRLSRATVQVYPHADTATLGALLEAC-TSQTKLIVT 178 Query: 252 ESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIA 311 ++V+SM G +A + ++ LA+++GA +D+ H G+ GP G G S Sbjct: 179 DTVFSMDGDIAPLAELLALAERHGAWLVVDDAHGFGVLGPQGRGALAAAALRS------- 231 Query: 312 TPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPP 371 P + GTLG + G G +V A +I+W A +IFTT PP Sbjct: 232 -PHL--------------VYVGTLGXAAGVAGAFVVAHETVIEWLIQRARSYIFTTAAPP 276 Query: 372 SVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNP--SH--IVPVLIGNA 427 +V +A+++ D +++ H + + L P SH + P++IG+ Sbjct: 277 AVAHAVSASLKV--IAGDEGDARRAHLAALIERTRALLRRTRWQPVDSHTAVQPLVIGSN 334 Query: 428 DLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTND 471 + A A+ ++ H ++V AI PTV GT RLRI+ + H+ D Sbjct: 335 E-ATLAAMRALDAHGLWVPAIRPPTVPAGTSRLRISLSAAHSFD 377 >3HQT-A nrPDB Length = 409 Score = 92.0 bits (227), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 81/356 (22%), Positives = 160/356 (44%), Gaps = 32/356 (8%) Query: 83 KKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPEVLDAMHKTIDK 142 + ++D + +IN+ K L +Q D + + SNDYLAL+ HP + + K++ + Sbjct: 31 QNKIDHYIENYFDINKNGKHLVLG-KQASPDDIILQ-SNDYLALANHPLIKARLAKSLLE 88 Query: 143 YGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVI 202 + + ++ +E LA + L+ S + AN +L + Q ++ I Sbjct: 89 EQQSLFMSASFLQNDYDKPMIEKRLAKFTGFDECLLSQSGWNANVGLLQTICQPNTNVYI 148 Query: 203 FSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVA 262 D H S+ G ++AN + H F HN+ + L L+Q + P +I +S+YS G++A Sbjct: 149 --DFFAHMSLWEGARYANAQAHPFMHNNCDHLRMLIQRHG---PGIIVVDSIYSTLGTIA 203 Query: 263 DIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAK 322 + ++ +++ ++G +DE H++G +GP+GAG+ A+ Sbjct: 204 PLAELVNISKEFGCALLVDESHSLGTHGPNGAGLL-----------------------AE 240 Query: 323 TVMDR-VDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAI 381 + R V +T +L K+F G + + ++ + IF++TL P AG + Sbjct: 241 LGLTREVHFMTASLAKTFAYRAGAIWCNNEVNRCVPFISYPAIFSSTLLPYEAAGLETTL 300 Query: 382 RYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIVPVLIGNADLAKQASDIL 437 + R + ++ +LG+ I + S I+ + G+ ++ D L Sbjct: 301 EIIESADNRRQHLDRMARKLRIGLSQLGL-TIRSESQIIGLETGDERNTEKVRDYL 355 >2CFB-A nrPDB Length = 411 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 47/179 (26%), Positives = 72/179 (40%), Gaps = 31/179 (17%) Query: 129 HPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDA 188 HPEV+DA+H ++K GT A + + E +A + E +S A A Sbjct: 54 HPEVIDALHAALEK------GTSFGAPCLLENILAEMVIAAVPSVEMVRFVNSGTEACMA 107 Query: 189 VLSLL---GQKMKDLVIFSDELNHASMIV-----GI------------KHANVKKHIFKH 228 VL L+ Q+ K + HA M + G+ K + Sbjct: 108 VLRLMRAYTQREKVIKFEGCYHGHADMFLVKAGSGVATLGLPDSPGVPKATTAATLTAPY 167 Query: 229 NDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVAD----IEKICDLADKYGALTFLDEV 283 NDL + +L + YP + +I E V AG + +E + +L +YGAL DEV Sbjct: 168 NDLEAVSRLFEQYPNDIAGVI-LEPVVGNAGFIPPDAGFLEGLRELTKQYGALLVFDEV 225 >3VK2-A nrPDB Length = 398 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 37/129 (28%), Positives = 62/129 (48%), Gaps = 7/129 (5%) Query: 159 PTLNL-EAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIV--G 215 PTLNL EA +A+L E L +S A + L L + ++++ + H + G Sbjct: 65 PTLNLLEARMASLEGGEAGLALASGMGAITSTLWTLLRPGDEVLLGNTLYGHTFAFLHHG 124 Query: 216 IKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYG 275 I VK +H D+ +L Q L++ ++I FES + +ADI + +A K+G Sbjct: 125 IGEFGVK---LRHVDMADL-QALEAAMTPATRVIYFESPANPNMHMADIAGVAKIARKHG 180 Query: 276 ALTFLDEVH 284 A +D + Sbjct: 181 ATVVVDNTY 189 >4OC9-A nrPDB Length = 424 Score = 35.4 bits (80), Expect = 0.068, Method: Compositional matrix adjust. Identities = 33/116 (28%), Positives = 57/116 (49%), Gaps = 11/116 (9%) Query: 216 IKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYG 275 +K+ ++ F +DL+ LE+++ K+ I FES+ + ++ADIEKI +A K+ Sbjct: 120 LKNFGIEAREFDIDDLDSLEKVIDQNTKA----IFFESLSNPQIAIADIEKINQIAKKHK 175 Query: 276 ALTFLDEVHAVG-LYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDM 330 ++ D A L P GV D H S + + GGA +++R D+ Sbjct: 176 IVSICDNTVATPFLLQPFKHGV----DVIVHSLSKYVSGQGTALGGA--LIERKDL 225 >5VMB-A nrPDB Length = 425 Score = 35.0 bits (79), Expect = 0.094, Method: Compositional matrix adjust. Identities = 23/60 (38%), Positives = 33/60 (55%), Gaps = 7/60 (11%) Query: 230 DLNELEQL-LQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGL 288 D E+E+L L+ P+ + +A S YS V D ++ D+ADK GA F+D H GL Sbjct: 162 DYEEVERLALEHKPRMI---VAGFSAYS---RVVDWQRFRDIADKVGAYLFVDMAHVAGL 215 >1N8P-A nrPDB Length = 393 Score = 34.7 bits (78), Expect = 0.10, Method: Compositional matrix adjust. Identities = 32/115 (27%), Positives = 50/115 (43%), Gaps = 4/115 (3%) Query: 162 NLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANV 221 NLE +A L + L FSS +L L Q + I + +A+ Sbjct: 59 NLERAVAALENAQYGLAFSSGSATTATILQSLPQGSHAVSIGDVYGGTHRYFTKVANAHG 118 Query: 222 KKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGA 276 + F ++ LN+L QL+ K KL+ E+ + V DI+K+ DL K+ A Sbjct: 119 VETSFTNDLLNDLPQLI----KENTKLVWIETPTNPTLKVTDIQKVADLIKKHAA 169 >1CS1-A nrPDB Length = 386 Score = 34.7 bits (78), Expect = 0.11, Method: Compositional matrix adjust. Identities = 19/47 (40%), Positives = 27/47 (57%) Query: 235 EQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLD 281 EQ L++ PKL+ ES + V DI KIC LA + GA++ +D Sbjct: 127 EQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREVGAVSVVD 173 >1GDE-A nrPDB Length = 389 Score = 33.5 bits (75), Expect = 0.23, Method: Compositional matrix adjust. Identities = 41/192 (21%), Positives = 83/192 (43%), Gaps = 34/192 (17%) Query: 263 DIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAK 322 D+E+I D ++ + DEV+ EH ++ R IA+ Sbjct: 181 DLEEIADFVVEHDLIVISDEVY-------------EHFIYDDARHYSIAS--------LD 219 Query: 323 TVMDRVDMITGTLGKSFGSVG---GYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATA 379 + +R + G K+F G G+VAA +I+ F ++ T P + + A A Sbjct: 220 GMFERTITVNG-FSKTFAMTGWRLGFVAAPSWIIERMVKFQ---MYNATCPVTFIQYAAA 275 Query: 380 -AIRYQRCHI---DLRTSQQKHTMYVKKAFHELGIPVI-PNPS-HIVPVLIGNADLAKQA 433 A++ +R ++R + V K +E+G+P + P + +I P + +K+ Sbjct: 276 KALKDERSWKAVEEMRKEYDRRRKLVWKRLNEMGLPTVKPKGAFYIFPRIRDTGLTSKKF 335 Query: 434 SDILINKHQIYV 445 S++++ + ++ V Sbjct: 336 SELMLKEARVAV 347 >4P3M-A nrPDB Length = 429 Score = 32.7 bits (73), Expect = 0.41, Method: Compositional matrix adjust. Identities = 50/201 (24%), Positives = 81/201 (40%), Gaps = 37/201 (18%) Query: 109 QREADKVTVWCSNDYLALSKHPEVLDAMHKTI-DKYGCGAGGTRNIAGHNI----PTLNL 163 QR+ D + + S +Y + P V++A + +KY G G R G +L + Sbjct: 24 QRQEDHIELIASENYTS----PRVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDVAESLAI 79 Query: 164 E-------AELATLHKKEG----ALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASM 212 E A+ A + G A V+ + D +L + + L H S Sbjct: 80 ERAKSLFGADYANVQPHSGSQANAAVYQALCAPGDTILGMS-------LAHGGHLTHGSH 132 Query: 213 IV--GIKHANVKKHIFKHN---DLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKI 267 + G + V+ I D E+E+L + ++ +IA S YS + D K Sbjct: 133 VSFSGKMYNAVQYGITPETGILDYAEIERLAVEHKPTM--IIAGFSAYS---GIVDWAKF 187 Query: 268 CDLADKYGALTFLDEVHAVGL 288 ++ADK GA F+D H GL Sbjct: 188 REIADKVGAYLFVDMAHVAGL 208 >4E77-A nrPDB Length = 429 Score = 32.7 bits (73), Expect = 0.43, Method: Compositional matrix adjust. Identities = 20/63 (31%), Positives = 33/63 (52%), Gaps = 11/63 (17%) Query: 228 HNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICD-------LADKYGALTFL 280 +NDL + Q + YP+ V +I V +AG++ I + + L D++GAL + Sbjct: 184 YNDLASVRQAFEQYPQEVACII----VEPVAGNMNCIPPLPEFLPGLRALCDEFGALLII 239 Query: 281 DEV 283 DEV Sbjct: 240 DEV 242 >3THY-A nrPDB Length = 934 Score = 32.7 bits (73), Expect = 0.47, Method: Compositional matrix adjust. Identities = 20/61 (32%), Positives = 34/61 (55%), Gaps = 6/61 (9%) Query: 78 DSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPEVLDAMH 137 D+EL++ + R F ++NRLAK+F QR+A + C Y +++ P V+ A+ Sbjct: 369 DAELRQTLQEDLLRRFPDLNRLAKKF-----QRQAANLQ-DCYRLYQGINQLPNVIQALE 422 Query: 138 K 138 K Sbjct: 423 K 423 >4RCT-A nrPDB Length = 365 Score = 32.0 bits (71), Expect = 0.64, Method: Compositional matrix adjust. Identities = 31/130 (23%), Positives = 57/130 (43%), Gaps = 6/130 (4%) Query: 152 NIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHAS 211 NIA I +L A L K ++ ++ YV+NDAV+ L K+ +L +D + Sbjct: 27 NIANAKITEKSLNAVWMDLFKSADEVLMATGYVSNDAVVEL--HKILEL---NDHIQKID 81 Query: 212 MIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLA 271 ++VG+ + H+ +++ L +L L+ + + F + S + +KI L Sbjct: 82 LLVGMHYLEGFSHL-QYDSLCKLNDFLRHEKRGAVYVSPFVKFHGKMYSFKNYQKINGLI 140 Query: 272 DKYGALTFLD 281 F D Sbjct: 141 GSANLTCFWD 150 >1IBJ-A nrPDB Length = 464 Score = 31.6 bits (70), Expect = 0.95, Method: Compositional matrix adjust. Identities = 32/120 (26%), Positives = 59/120 (49%), Gaps = 5/120 (4%) Query: 163 LEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVK 222 LE+ LA L K + A F+S A AV L+ K + ++ D++ S + + Sbjct: 138 LESLLAKLDKADRAFCFTSGMAALSAVTHLI--KNGEEIVAGDDVYGGSDRLLSQVVPRS 195 Query: 223 KHIFKHNDLNELEQLLQSY-PKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLD 281 + K + +L+++ + P++ KL+ ES + ++DI KI ++A GAL +D Sbjct: 196 GVVVKRVNTTKLDEVAAAIGPQT--KLVWLESPTNPRQQISDIRKISEMAHAQGALVLVD 253 >3MKJ-A nrPDB Length = 398 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 35/130 (26%), Positives = 58/130 (44%), Gaps = 15/130 (11%) Query: 159 PTLN-LEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIK 217 PT + LE +LA L + E L +S A L L Q+ D + AS I G Sbjct: 64 PTTDALEKKLAVLERGEAGLATASGISAITTTLLTLCQQ-------GDHIVSASAIYGCT 116 Query: 218 HANVKKHIFKHN------DLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLA 271 HA + + K D + E++ ++ + K++ E+ + S+ DIE + +A Sbjct: 117 HAFLSHSMPKFGINVSFVDAAKPEEI-RAAMRPETKVVYIETPANPTLSLVDIETVAGIA 175 Query: 272 DKYGALTFLD 281 + GAL +D Sbjct: 176 HQQGALLVVD 185 >3N0L-A nrPDB Length = 417 Score = 30.4 bits (67), Expect = 2.1, Method: Compositional matrix adjust. Identities = 51/195 (26%), Positives = 82/195 (42%), Gaps = 26/195 (13%) Query: 109 QREADKVTVWCSNDYLALSKHPEVLDAMHKTI-DKYGCGAGGTRNIAG----HNIPTLNL 163 +R+ + + + S ++ PEV++ M + +KY G G R G I TL + Sbjct: 22 ERQCEGLEMIASENFTL----PEVMEVMGSILTNKYAEGYPGKRYYGGCEFVDEIETLAI 77 Query: 164 EAELATLHKKEGALVFSSCYVANDAVLSLL---GQKMKDLVIFSDELNHASMIV-GIKHA 219 E + K + +S AN V + L G K I +L+H + G K + Sbjct: 78 ERCKKLFNCKFANVQPNSGSQANQGVYAALINPGDK-----ILGMDLSHGGHLTHGAKVS 132 Query: 220 NVKK---HIFKHNDLN---ELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADK 273 + K F +L+ + E++ + K PKLI + S V D K ++AD+ Sbjct: 133 SSGKMYESCFYGVELDGRIDYEKVREIAKKEKPKLIVCGA--SAYARVIDFAKFREIADE 190 Query: 274 YGALTFLDEVHAVGL 288 GA F D H GL Sbjct: 191 IGAYLFADIAHIAGL 205 >3GBX-A nrPDB Length = 420 Score = 30.4 bits (67), Expect = 2.3, Method: Compositional matrix adjust. Identities = 19/59 (32%), Positives = 30/59 (50%), Gaps = 5/59 (8%) Query: 230 DLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGL 288 D +E+ +L + + PK+I +S V D K+ ++AD GA F+D H GL Sbjct: 157 DYDEMAKLAKEHK---PKMII--GGFSAYSGVVDWAKMREIADSIGAYLFVDMAHVAGL 210 >3G8M-A nrPDB Length = 417 Score = 30.0 bits (66), Expect = 2.5, Method: Compositional matrix adjust. Identities = 20/61 (32%), Positives = 30/61 (49%), Gaps = 5/61 (8%) Query: 228 HNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVG 287 H D +LE+ + + PK+I +S V D K+ ++AD GA F+D H G Sbjct: 152 HIDYADLEKQAKEHK---PKMII--GGFSAYSGVVDWAKMREIADSIGAYLFVDMAHVAG 206 Query: 288 L 288 L Sbjct: 207 L 207 >4BWG-A nrPDB Length = 347 Score = 30.0 bits (66), Expect = 2.8, Method: Compositional matrix adjust. Identities = 26/87 (29%), Positives = 38/87 (43%), Gaps = 10/87 (11%) Query: 7 ARFGNSSAAVSTLNRLSTTAAPHAKNGYATATGAGAAAATATASSTHAAA------AAAA 60 +RFGN+ ++ + T P AK G TG+G + ATA S AA A A Sbjct: 240 SRFGNNWVDIAAPGQNITFLRPDAKTG----TGSGTSEATAIVSGVLAAMTSCNPRATAT 295 Query: 61 AANHSTQESGFDYEGLIDSELQKKRLD 87 + ES Y L+D + + L+ Sbjct: 296 ELKRTLLESADKYPSLVDKVTEGRVLN 322 >6A2F-A nrPDB Length = 358 Score = 30.0 bits (66), Expect = 3.0, Method: Compositional matrix adjust. Identities = 24/86 (27%), Positives = 35/86 (40%), Gaps = 15/86 (17%) Query: 131 EVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVL 190 EV+ A+H D G + L AE+ LH L+ C+ A++ L Sbjct: 44 EVVTALHDDAD-------------GFAVACLEEAAEVRALHASARILLLEGCFEASEYAL 90 Query: 191 SLLGQKMKDLVIFSDELNHASMIVGI 216 + GQ DLVI E A + G+ Sbjct: 91 A--GQLRLDLVIQGAEQGEAFLAAGL 114 >3FDB-A nrPDB Length = 377 Score = 29.6 bits (65), Expect = 3.2, Method: Compositional matrix adjust. Identities = 15/38 (39%), Positives = 25/38 (65%), Gaps = 3/38 (7%) Query: 264 IEKICDLADKYGALTFLDEVHAVGLY-GPH--GAGVAE 298 + ++CDLA +Y A +DE+HA ++ G H AGV++ Sbjct: 172 LNELCDLAHRYDARVLVDEIHAPLVFDGQHTVAAGVSD 209 >5XT5-A nrPDB Length = 419 Score = 28.9 bits (63), Expect = 6.4, Method: Compositional matrix adjust. Identities = 53/237 (22%), Positives = 93/237 (39%), Gaps = 33/237 (13%) Query: 95 NINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPEVLDAMHKTIDKY----------G 144 NI + ++FP+ H+Q + D A S+ P A+ +T+DKY G Sbjct: 5 NITDIREQFPILHQQVNGHDLVYL---DSAATSQKPR---AVIETLDKYYNQYNSNVHRG 58 Query: 145 CGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMK--DLVI 202 GTR G+ + + E + N LS +K D V+ Sbjct: 59 VHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALSYARANLKPGDEVV 118 Query: 203 FSDELNHASMIVGIKHANVKKHIFKHNDLNE-----LEQLLQSYPKSVPKLIAFESVYSM 257 + +HA++I + K+ L E LE + ++ + K++A V ++ Sbjct: 119 ITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVTSNT-KIVAVSHVSNV 177 Query: 258 AGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAE--HCDF---ESHRASG 309 G+V I+++ +A GA+ +D + PH + CDF SH+ G Sbjct: 178 LGTVNPIKEMAKIAHDNGAVIVVDGAQST----PHMKIDVQDLDCDFFALSSHKMCG 230 >4AD9-A nrPDB Length = 289 Score = 28.9 bits (63), Expect = 6.7, Method: Compositional matrix adjust. Identities = 16/54 (29%), Positives = 27/54 (50%) Query: 432 QASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVDDVFN 485 Q +I+ N Q YV + + LR+ TPGHT+D +L+ + +F+ Sbjct: 110 QREEIIGNGEQQYVYLKDGDVIKTEGATLRVLYTPGHTDDHMALLLEEENAIFS 163 >1E5F-A nrPDB Length = 404 Score = 28.5 bits (62), Expect = 7.7, Method: Compositional matrix adjust. Identities = 37/126 (29%), Positives = 59/126 (46%), Gaps = 6/126 (4%) Query: 159 PTL-NLEAELATLHKKEGALVFSSCYVANDA-VLSLLGQKMKDLVIFSDELNHASMIVGI 216 PT+ NLE ++A L K E + SS A A VL++L K D +I SDE + Sbjct: 62 PTVSNLEGKIAFLEKTEACVATSSGMGAIAATVLTIL--KAGDHLI-SDECLYGCTHALF 118 Query: 217 KHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKIC-DLADKYG 275 +HA K I + ++ + K K++ FE+ + + D+E++C D + G Sbjct: 119 EHALTKFGIQVDFINTAIPGEVKKHMKPNTKIVYFETPANPTLKIIDMERVCKDAHSQEG 178 Query: 276 ALTFLD 281 L D Sbjct: 179 VLVIAD 184 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5TXT-B nrPDB 708 0.0 6HRH-B nrPDB 507 e-144 2BWN-A nrPDB 479 e-135 4BMK-A nrPDB 461 e-130 3TQX-A nrPDB 432 e-121 1FC4-A nrPDB 427 e-120 2X8U-A nrPDB 424 e-119 3A2B-A nrPDB 420 e-118 4IW7-A nrPDB 378 e-105 5JAY-A nrPDB 375 e-104 6ONN-A nrPDB 375 e-104 1DJ9-A nrPDB 357 8e-99 3HQT-A nrPDB 352 3e-97 5VNX-A nrPDB 314 6e-86 3WY7-A nrPDB 306 1e-83 2CFB-A nrPDB 133 2e-31 Sequences not found previously or not previously below threshold: 4GSA-A nrPDB 114 1e-25 5HDM-A nrPDB 103 2e-22 3BS8-A nrPDB 93 3e-19 2E7U-A nrPDB 81 9e-16 5I92-A nrPDB 80 2e-15 4E77-A nrPDB 78 1e-14 3K28-A nrPDB 78 1e-14 1YJS-A nrPDB 69 4e-12 2EPJ-A nrPDB 69 5e-12 4OTL-A nrPDB 66 5e-11 3L44-A nrPDB 66 6e-11 4P3M-A nrPDB 64 2e-10 1M6S-A nrPDB 64 2e-10 3G8M-A nrPDB 62 6e-10 4AOA-A nrPDB 60 2e-09 3GBX-A nrPDB 60 2e-09 4ADC-A nrPDB 57 2e-08 1VJO-A nrPDB 56 3e-08 2DKJ-A nrPDB 56 3e-08 4J5U-A nrPDB 56 4e-08 5YKR-A nrPDB 56 4e-08 2E54-A nrPDB 54 1e-07 5XT5-A nrPDB 54 1e-07 5VMB-A nrPDB 54 1e-07 3VK2-A nrPDB 54 2e-07 4OBV-D nrPDB 53 4e-07 4JF0-A nrPDB 53 4e-07 2YKV-A nrPDB 52 6e-07 4ZM4-A nrPDB 52 6e-07 2CY8-A nrPDB 52 9e-07 2EO5-A nrPDB 51 1e-06 1WKH-A nrPDB 51 1e-06 1M32-A nrPDB 51 1e-06 3CQ5-A nrPDB 51 2e-06 2HUU-A nrPDB 50 2e-06 4BQ0-A nrPDB 50 3e-06 4W91-A nrPDB 49 4e-06 5VIU-A nrPDB 49 5e-06 4WXB-A nrPDB 49 5e-06 3N0L-A nrPDB 49 6e-06 5X3F-A nrPDB 49 6e-06 6GIO-D nrPDB 49 6e-06 3H7F-A nrPDB 48 1e-05 1Z7D-A nrPDB 48 1e-05 6MRE-A nrPDB 47 2e-05 2DR1-A nrPDB 46 3e-05 3NTJ-A nrPDB 46 4e-05 3ECD-A nrPDB 46 6e-05 2CTZ-A nrPDB 46 6e-05 5W1B-A nrPDB 45 1e-04 3PGY-A nrPDB 45 1e-04 3MKJ-A nrPDB 44 1e-04 5V1X-E nrPDB 44 1e-04 4RAE-A nrPDB 44 1e-04 4E3Q-A nrPDB 44 1e-04 2FNU-A nrPDB 44 2e-04 3WGB-A nrPDB 44 2e-04 1IBJ-A nrPDB 44 2e-04 3KGX-A nrPDB 43 3e-04 3NYS-A nrPDB 43 4e-04 4PIW-A nrPDB 43 4e-04 5LUC-A nrPDB 43 4e-04 5X5H-A nrPDB 43 4e-04 3OP7-A nrPDB 42 4e-04 4U1T-A nrPDB 42 5e-04 5DDW-A nrPDB 42 5e-04 1QZ9-A nrPDB 42 7e-04 4PPM-A nrPDB 42 7e-04 5O5C-A nrPDB 41 0.001 5VC2-A nrPDB 41 0.001 3DR4-A nrPDB 41 0.001 2Z9W-A nrPDB 41 0.001 1V2E-A nrPDB 41 0.001 5KR5-A nrPDB 41 0.001 1MDZ-A nrPDB 41 0.002 3BB8-A nrPDB 41 0.002 3UWC-A nrPDB 41 0.002 3PJ0-A nrPDB 40 0.002 4IYO-A nrPDB 40 0.002 5Z0Y-A nrPDB 40 0.003 5LH9-A nrPDB 40 0.003 2JJG-A nrPDB 40 0.003 5KR3-A nrPDB 39 0.004 5KQU-A nrPDB 39 0.004 1ECX-A nrPDB 39 0.005 6IO1-A nrPDB 39 0.005 3GJU-A nrPDB 39 0.007 3A8U-X nrPDB 39 0.007 5KQW-A nrPDB 38 0.009 2CH1-A nrPDB 38 0.009 6CJB-A nrPDB 38 0.009 4RIT-B nrPDB 38 0.011 4ZWV-A nrPDB 37 0.013 3N5M-A nrPDB 37 0.014 1CS1-A nrPDB 37 0.019 5K8B-A nrPDB 37 0.019 1OHW-A nrPDB 37 0.025 4BWG-A nrPDB 37 0.027 6ENZ-A nrPDB 37 0.028 3FDB-A nrPDB 36 0.031 5KR6-A nrPDB 36 0.033 2CB1-A nrPDB 36 0.034 1SFF-A nrPDB 36 0.039 2GB3-A nrPDB 36 0.040 4WBT-A nrPDB 36 0.043 4Q75-A nrPDB 36 0.050 3LWS-A nrPDB 36 0.059 4KAM-A nrPDB 36 0.060 2C81-A nrPDB 35 0.078 1T3I-A nrPDB 35 0.080 2JIS-A nrPDB 35 0.089 5KQT-A nrPDB 35 0.093 2YRI-A nrPDB 35 0.11 5TSU-A nrPDB 34 0.12 6HNV-A nrPDB 34 0.12 1I43-A nrPDB 34 0.13 1IJI-A nrPDB 34 0.14 6B9O-A nrPDB 34 0.17 3QI6-A nrPDB 33 0.26 2GMS-A nrPDB 33 0.28 3G7Q-A nrPDB 33 0.29 3NNK-A nrPDB 33 0.30 6CCZ-A nrPDB 33 0.38 5WGB-A nrPDB 32 0.46 4K2M-A nrPDB 32 0.58 2XYY-A nrPDB 32 0.59 5EJ2-A nrPDB 32 0.81 5DX5-A nrPDB 31 1.0 2YWJ-A nrPDB 31 1.1 3GR7-A nrPDB 31 1.3 3BXZ-A nrPDB 31 1.5 2FSI-A nrPDB 31 1.5 5K9T-A nrPDB 31 1.6 3ZRR-A nrPDB 31 1.8 3GC2-A nrPDB 31 1.8 1CSR-A nrPDB 30 2.8 4L0O-H nrPDB 30 3.2 4FHA-A nrPDB 30 3.4 3CAI-A nrPDB 30 3.5 4EAR-A nrPDB 29 3.8 3HNO-A nrPDB 29 4.3 3IUU-A nrPDB 29 4.4 2OC4-A nrPDB 29 6.9 6A2F-A nrPDB 29 8.0 4JN6-A nrPDB 29 8.0 >5TXT-B nrPDB Length = 491 Score = 708 bits (1827), Expect = 0.0, Method: Composition-based stats. Identities = 491/491 (100%), Positives = 491/491 (100%) Query: 58 AAAAANHSTQESGFDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTV 117 AAAAANHSTQESGFDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTV Sbjct: 1 AAAAANHSTQESGFDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTV 60 Query: 118 WCSNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGAL 177 WCSNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGAL Sbjct: 61 WCSNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGAL 120 Query: 178 VFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQL 237 VFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQL Sbjct: 121 VFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQL 180 Query: 238 LQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVA 297 LQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVA Sbjct: 181 LQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVA 240 Query: 298 EHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFR 357 EHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFR Sbjct: 241 EHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFR 300 Query: 358 SFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPS 417 SFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPS Sbjct: 301 SFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPS 360 Query: 418 HIVPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILI 477 HIVPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILI Sbjct: 361 HIVPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILI 420 Query: 478 NAVDDVFNELQLPRVRDWESQGGLLGVGESGFVEESNLWTSSQLSLTNDDLNPNVRDPIV 537 NAVDDVFNELQLPRVRDWESQGGLLGVGESGFVEESNLWTSSQLSLTNDDLNPNVRDPIV Sbjct: 421 NAVDDVFNELQLPRVRDWESQGGLLGVGESGFVEESNLWTSSQLSLTNDDLNPNVRDPIV 480 Query: 538 KQLEVSSGIKQ 548 KQLEVSSGIKQ Sbjct: 481 KQLEVSSGIKQ 491 >6HRH-B nrPDB Length = 469 Score = 507 bits (1305), Expect = e-144, Method: Composition-based stats. Identities = 187/429 (43%), Positives = 282/429 (65%), Gaps = 28/429 (6%) Query: 68 ESGFDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREAD----KVTVWCSNDY 123 +S F Y+ ++ +K+ D +YR F +NR A +P A EA V+VWCSNDY Sbjct: 22 QSMFSYDQFFRDKIMEKKQDHTYRVFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDY 81 Query: 124 LALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCY 183 L +S+HP+VL A +T+ ++G GAGGTRNI+G + + LE ELA LH+K+ AL+FSSC+ Sbjct: 82 LGMSRHPQVLQATQETLQRHGVGAGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCF 141 Query: 184 VANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPK 243 VAND+ L L + + I+SD NHASMI GI+++ K +F+HND + L++LL+ Sbjct: 142 VANDSTLFTLAKILPGCEIYSDAGNHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKSNP 201 Query: 244 SVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFE 303 +PK++AFE+V+SM G++ +E++CD++ +YGALTF+DEVHAVGLYG GAG+ E Sbjct: 202 KIPKIVAFETVHSMDGAICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIGER---- 257 Query: 304 SHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGF 363 +M ++D+I+GTLGK+FG VGGY+A++R L+D RS+A GF Sbjct: 258 ------------------DGIMHKIDIISGTLGKAFGCVGGYIASTRDLVDMVRSYAAGF 299 Query: 364 IFTTTLPPSVMAGATAAIRYQRCHID--LRTSQQKHTMYVKKAFHELGIPVIPNPSHIVP 421 IFTT+LPP V++GA ++R + LR + Q++ ++++ + G+PVIP PSHI+P Sbjct: 300 IFTTSLPPMVLSGALESVRLLKGEEGQALRRAHQRNVKHMRQLLMDRGLPVIPCPSHIIP 359 Query: 422 VLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVD 481 + +GNA L + D+L++KH IYVQAIN+PTV RG E LR+ P+P H+ + + + + Sbjct: 360 IRVGNAALNSKLCDLLLSKHGIYVQAINYPTVPRGEELLRLAPSPHHSPQMMEDFVEKLL 419 Query: 482 DVFNELQLP 490 + + LP Sbjct: 420 LAWTAVGLP 428 >2BWN-A nrPDB Length = 401 Score = 479 bits (1232), Expect = e-135, Method: Composition-based stats. Identities = 199/419 (47%), Positives = 265/419 (63%), Gaps = 27/419 (6%) Query: 71 FDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQRE---ADKVTVWCSNDYLALS 127 DY +D +QK + YR F +I R FP A R +TVWC NDYL + Sbjct: 1 MDYNLALDKAIQKLHDEGRYRTFIDIEREKGAFPKAQWNRPDGGKQDITVWCGNDYLGMG 60 Query: 128 KHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVAND 187 +HP VL AMH+ ++ G G+GGTRNI+G LEAE+A LH+KE ALVFSS Y AND Sbjct: 61 QHPVVLAAMHEALEAVGAGSGGTRNISGTTAYHRRLEAEIAGLHQKEAALVFSSAYNAND 120 Query: 188 AVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPK 247 A LS L L+I+SD LNHASMI GIK K IF+HND+ L +L+ + + PK Sbjct: 121 ATLSTLRVLFPGLIIYSDSLNHASMIEGIKRNAGPKRIFRHNDVAHLRELIAADDPAAPK 180 Query: 248 LIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRA 307 LIAFESVYSM G I++ICD+A+++GALT++DEVHAVG+YGP GAGVAE Sbjct: 181 LIAFESVYSMDGDFGPIKEICDIAEEFGALTYIDEVHAVGMYGPRGAGVAER-------- 232 Query: 308 SGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTT 367 +M R+D+ GTL K++G GGY+AAS +++D RS+APGFIF+T Sbjct: 233 --------------DGLMHRIDIFNGTLAKAYGVFGGYIAASARMVDAVRSYAPGFIFST 278 Query: 368 TLPPSVMAGATAAIRYQRCHI--DLRTSQQKHTMYVKKAFHELGIPVIPNPSHIVPVLIG 425 +LPP++ AGA A+I + + LR +QQ H +K LG+P+I + SHIVPV+IG Sbjct: 279 SLPPAIAAGAQASIAFLKTAEGQKLRDAQQMHAKVLKMRLKALGMPIIDHGSHIVPVVIG 338 Query: 426 NADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVDDVF 484 + K SD+L++ + +YVQ INFPTV RGTERLR TP+P H D L++A+D ++ Sbjct: 339 DPVHTKAVSDMLLSDYGVYVQPINFPTVPRGTERLRFTPSPVHDLKQIDGLVHAMDLLW 397 >4BMK-A nrPDB Length = 442 Score = 461 bits (1186), Expect = e-130, Method: Composition-based stats. Identities = 118/450 (26%), Positives = 206/450 (45%), Gaps = 40/450 (8%) Query: 52 THAAAAAAAAANHSTQESGFD----------YEGLIDSELQKKRLDKSYRYFNNINRLAK 101 +H A+ AAA H+ D ++GLI ++K LD I Sbjct: 18 SHMASTEAAAQPHALPADAPDIAPERDLLSKFDGLIAE--RQKLLDSGVTDPFAIVMEQV 75 Query: 102 EFPLAHRQREADKVTVWCSNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTL 161 + P R D + + N Y+ ++ P+V+ A + ++K+G G G+R + G + Sbjct: 76 KSPTEAVIRGKDTILLGTYN-YMGMTFDPDVIAAGKEALEKFGSGTNGSRMLNGTFHDHM 134 Query: 162 NLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANV 221 +E L + GA+VFS+ Y+AN ++S L K + +++ +D +HAS+ G + N Sbjct: 135 EVEQALRDFYGTTGAIVFSTGYMANLGIISTLAGKGEYVILDAD--SHASIYDGCQQGNA 192 Query: 222 KKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLD 281 + F+HN + +L++ L PK KL+ E VYSM G +A ++++ +A K+GA+ +D Sbjct: 193 EIVRFRHNSVEDLDKRLGRLPKEPAKLVVLEGVYSMLGDIAPLKEMVAVAKKHGAMVLVD 252 Query: 282 EVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGS 341 E H++G +GP+G GV E A+ + ++D + GT S G+ Sbjct: 253 EAHSMGFFGPNGRGVYE----------------------AQGLEGQIDFVVGTFSASVGT 290 Query: 342 VGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYV 401 VGG+V ++ + R +IFT +LPPSV+A AT +IR + R + + Sbjct: 291 VGGFVVSNHPKFEAVRLACRPYIFTASLPPSVVATATTSIRKLMTAHEKRERLWSNARAL 350 Query: 402 KKAFHELGIPVI--PNPSHIVPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTER 459 +G + S IV V++ + + A L++ +YV P GT Sbjct: 351 HGGLKAMGFRLGTETCDSAIVAVMLEDQEQAAMMWQALLDG-GLYVNMARPPATPAGTFL 409 Query: 460 LRITPTPGHTNDLSDILINAVDDVFNELQL 489 LR + HT ++ + + Sbjct: 410 LRCSICAEHTPAQIQTVLGMFQAAGRAVGV 439 >3TQX-A nrPDB Length = 399 Score = 432 bits (1110), Expect = e-121, Method: Composition-based stats. Identities = 126/416 (30%), Positives = 212/416 (50%), Gaps = 33/416 (7%) Query: 77 IDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPEVLDAM 136 ++ E++ + Y+ I A + +V +C+N+YL L+ HP ++ Sbjct: 11 LNKEIEGLKKAGLYKSERIITSPQN----AEIKVGEKEVLNFCANNYLGLADHPALIKTA 66 Query: 137 HKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQK 196 +++YG G R I G LE +++ + +++SSC+ AN + L Sbjct: 67 QTVVEQYGFGMASVRFICGTQTIHKELEKDISEFLGTDDTILYSSCFDANGGLFETL--L 124 Query: 197 MKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVP--KLIAFESV 254 + I SDELNHAS+I GI+ +++ +K+N + +LE L+ + KLIA + V Sbjct: 125 GPEDAIISDELNHASIIDGIRLCKAQRYRYKNNAMGDLEAKLKEADEKGARFKLIATDGV 184 Query: 255 YSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPK 314 +SM G +AD++ ICDLADKY AL +D+ HAVG G +G G E+C Sbjct: 185 FSMDGIIADLKSICDLADKYNALVMVDDSHAVGFIGENGRGTPEYCG------------- 231 Query: 315 TNDKGGAKTVMDRVDMITGTLGKSFGSV-GGYVAASRKLIDWFRSFAPGFIFTTTLPPSV 373 V DRVD++TGTLGK+ G GGY + +++I+W R+ + ++F+ T+ P + Sbjct: 232 ---------VADRVDILTGTLGKALGGASGGYTSGHKEIIEWLRNRSRPYLFSNTVAPVI 282 Query: 374 MAGATAAIRYQRCH-IDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIVPVLIGNADLAKQ 432 +A + + + LR Q+++ Y + +LG ++P I+PV++G+A LA Sbjct: 283 VATSLKVLELLKTEGPQLRKQLQENSRYFRAGMEKLGFQLVPGNHPIIPVMLGDAQLATN 342 Query: 433 ASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVDDVFNELQ 488 +D L+ + IYV ++P V G R+R+ + HT D I A V +L Sbjct: 343 MADHLLQE-GIYVVGFSYPVVPMGKARIRVQMSAVHTQQQLDRAIEAFGQVGKKLG 397 >1FC4-A nrPDB Length = 401 Score = 427 bits (1098), Expect = e-120, Method: Composition-based stats. Identities = 122/421 (28%), Positives = 211/421 (50%), Gaps = 31/421 (7%) Query: 72 DYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPE 131 ++ + ++L+ R + ++ I + + V +C+N+YL L+ HP+ Sbjct: 7 EFYQQLTNDLETARAEGLFKEERIITSAQQA---DITVADGSHVINFCANNYLGLANHPD 63 Query: 132 VLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLS 191 ++ A +D +G G R I G LE +LA E A+++SSC+ AN + Sbjct: 64 LIAAAKAGMDSHGFGMASVRFICGTQDSHKELEQKLAAFLGMEDAILYSSCFDANGGLFE 123 Query: 192 LLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPK--LI 249 L + I SD LNHAS+I G++ K++ + +ND+ ELE L+ ++ + LI Sbjct: 124 TL--LGAEDAIISDALNHASIIDGVRLCKAKRYRYANNDMQELEARLKEAREAGARHVLI 181 Query: 250 AFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASG 309 A + V+SM G +A+++ +CDLADKY AL +D+ HAVG G +G G E+CD Sbjct: 182 ATDGVFSMDGVIANLKGVCDLADKYDALVMVDDSHAVGFVGENGRGSHEYCD-------- 233 Query: 310 IATPKTNDKGGAKTVMDRVDMITGTLGKSFGSV-GGYVAASRKLIDWFRSFAPGFIFTTT 368 VM RVD+ITGTLGK+ G GGY AA +++++W R + ++F+ + Sbjct: 234 --------------VMGRVDIITGTLGKALGGASGGYTAARKEVVEWLRQRSRPYLFSNS 279 Query: 369 LPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIVPVLIGNAD 428 L P+++A + + +LR + ++ G + I+PV++G+A Sbjct: 280 LAPAIVAASIKVLEMVEAGSELRDRLWANARQFREQMSAAGFTLAGADHAIIPVMLGDAV 339 Query: 429 LAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVDDVFNELQ 488 +A++ + L K IYV +P V +G R+R + HT + + A + +L Sbjct: 340 VAQKFAREL-QKEGIYVTGFFYPVVPKGQARIRTQMSAAHTPEQITRAVEAFTRIGKQLG 398 Query: 489 L 489 + Sbjct: 399 V 399 >2X8U-A nrPDB Length = 412 Score = 424 bits (1091), Expect = e-119, Method: Composition-based stats. Identities = 102/419 (24%), Positives = 186/419 (44%), Gaps = 30/419 (7%) Query: 73 YEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPEV 132 ++ LI ++ L R I P K + + +Y+ ++ P+V Sbjct: 7 FDPLIAE--REALLATGVRDPYAIVMDKVLSPTEAMI-NGRKTILLGTYNYMGMTFDPDV 63 Query: 133 LDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSL 192 + A + +D++G G G+R + G E L + E A+VFS+ Y AN ++S Sbjct: 64 IAAGKQALDEFGSGTTGSRVLNGTYQGHKACEDALKEFYGTEHAIVFSTGYQANLGMIST 123 Query: 193 LGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFE 252 L K +++ +D +HAS+ G + + F+HN + +L++ L P KL+ E Sbjct: 124 LAGKGDYIILDAD--SHASIYDGCWLGDAEIVRFRHNSVEDLDKRLGRLPAEAGKLVVLE 181 Query: 253 SVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIAT 312 VYSM G +A ++++ ++ K+GA+ +DE H +G +G HG GV E E+ Sbjct: 182 GVYSMMGDIAPLQEMVAVSKKHGAMILVDEAHGMGFFGEHGRGVFEEAGVEA-------- 233 Query: 313 PKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPS 372 VD + GT KS G+VGG+ ++ + R ++FT +LPPS Sbjct: 234 --------------DVDFVVGTFSKSVGTVGGFCVSNHPKFEVLRLVCRPYVFTASLPPS 279 Query: 373 VMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNP--SHIVPVLIGNADLA 430 V+A A +IR D R K++ + + ++G + S I+ V++ + A Sbjct: 280 VVATAATSIRKLMHAGDKRAHLWKNSRRLHQGLRDMGYKLGTETAQSAIIAVILTDMAQA 339 Query: 431 KQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVDDVFNELQL 489 L+ + +YV P G LR + H+++ + ++ + + Sbjct: 340 VALWQGLL-EAGLYVNTARPPATPAGMFLLRCSLCAEHSDEQVEQILGMFESAGRATGV 397 >3A2B-A nrPDB Length = 398 Score = 420 bits (1079), Expect = e-118, Method: Composition-based stats. Identities = 108/415 (26%), Positives = 192/415 (46%), Gaps = 34/415 (8%) Query: 77 IDSELQKKRLDKSYRYFNNI-NRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPEVLDA 135 I EL+ K L Y YF I ++ E + + +V ++ SN YL L+ ++ A Sbjct: 14 IVEELKAKGL---YAYFRPIQSKQDTEVKI-----DGRRVLMFGSNSYLGLTTDTRIIKA 65 Query: 136 MHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQ 195 ++KYG G G+R + G + LE +L+ KE A++FS+ + +N LS L Sbjct: 66 AQDALEKYGTGCAGSRFLNGTLDIHVELEEKLSAYVGKEAAILFSTGFQSNLGPLSCL-- 123 Query: 196 KMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVY 255 ++ I DE +HAS+I G + + K + HN++ +L L P+ KLI + ++ Sbjct: 124 MGRNDYILLDERDHASIIDGSRLSFSKVIKYGHNNMEDLRAKLSRLPEDSAKLICTDGIF 183 Query: 256 SMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKT 315 SM G + ++ ++ +A+++ A +D+ H++G+ G GAG A H Sbjct: 184 SMEGDIVNLPELTSIANEFDAAVMVDDAHSLGVIGHKGAGTASHFGLN------------ 231 Query: 316 NDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMA 375 D VD+I GT KS S+GG+VA +ID+ + A +F+ ++ P+ +A Sbjct: 232 ----------DDVDLIMGTFSKSLASLGGFVAGDADVIDFLKHNARSVMFSASMTPASVA 281 Query: 376 GATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIVPVLIGNADLAKQASD 435 A+ + + K+T Y K + G + S I+P+ I + + + Sbjct: 282 STLKALEIIQNEPEHIEKLWKNTDYAKAQLLDHGFDLGATESPILPIFIRSNEKTFWVTK 341 Query: 436 ILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVDDVFNELQLP 490 +L ++V + P V +R + HT D D I + VF + ++ Sbjct: 342 ML-QDDGVFVNPVVSPAVPAEESLIRFSLMATHTYDQIDEAIEKMVKVFKQAEVE 395 >4IW7-A nrPDB Length = 399 Score = 378 bits (969), Expect = e-105, Method: Composition-based stats. Identities = 108/421 (25%), Positives = 188/421 (44%), Gaps = 41/421 (9%) Query: 74 EGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPEVL 133 S DK +Y + N L + P + D + + ++DYL LS + Sbjct: 17 NLYFQSNAMLNLQDKYTQYQRD-NLLRELTPF----IKDDSIIDFTTSDYLNLSSAHNLK 71 Query: 134 DAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLL 193 A+ DKYG G+ G+ + G+ T E E A A+ FSS ++AN A+ S L Sbjct: 72 HAIVNGFDKYGFGSKGSNIVCGYTDETQQFEHEFAKFINYPRAIFFSSGFMANLAIYSTL 131 Query: 194 GQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFES 253 K IF+D+ HAS+I GIK + K +KH L++L+ + I E Sbjct: 132 FSKHDS--IFADKYIHASIIDGIKLSQAKLRRYKHQQLSQLQDIY-----DGKSFITTEG 184 Query: 254 VYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATP 313 V+S +GS+ ++K+ + + +DE H+ G+ G +G G I + Sbjct: 185 VFSTSGSITQLDKLAKITPEK---LIVDEAHSFGVLGKNGRG-------------AINSF 228 Query: 314 KTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSV 373 + + K V LGK+FG VG V + + ++ FA +I+TT LPP + Sbjct: 229 RISYKNCLICVF--------PLGKAFGGVGAVVCTTEAIAEYLIQFARNYIYTTALPPMI 280 Query: 374 MAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVI-PNPSHIVPVLIGNADLAKQ 432 + A ++ D R Q++ + + + ++ + S I + + NA+LA + Sbjct: 281 LKAALIQLKNLENVNDNRARLQQNITFFNELCDAKDLELVSKDLSPIRSIQLNNANLAIR 340 Query: 433 ASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVDDVFNELQLPRV 492 D L +++I V +PTV + LR + H+N+ D + A++ + E++ + Sbjct: 341 LKDKLF-ENKIIVSCFRYPTVPKDQAILRFSL---HSNNTFDQIQQALEIISKEVKYEYI 396 Query: 493 R 493 R Sbjct: 397 R 397 >5JAY-A nrPDB Length = 402 Score = 375 bits (963), Expect = e-104, Method: Composition-based stats. Identities = 118/418 (28%), Positives = 194/418 (46%), Gaps = 34/418 (8%) Query: 77 IDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPEVLDAM 136 + L + + R R A AH + + + SNDYL L+ HP+++ A+ Sbjct: 11 LLDTLAEGLKEIDARGLRRRRRTADTPCAAHMTVDGRAIIGFASNDYLGLAAHPQLIAAI 70 Query: 137 HKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHK----KEGALVFSSCYVANDAVLSL 192 + +YG G+GG+ + GH+ LE +LA AL FS+ Y+AN A L+ Sbjct: 71 AEGAQRYGAGSGGSHLLGGHSRAHAQLEDDLAEFVGGFVENARALYFSTGYMANLATLTA 130 Query: 193 LGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFE 252 L + +FSD LNHAS+I G + + I+ H D + L +L++ V K+I + Sbjct: 131 LAGRGTT--LFSDALNHASLIDGARLSRADVQIYPHCDTDALSAMLEASDADV-KVIVSD 187 Query: 253 SVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIAT 312 +V+SM G +A + ++ +LA+++GA +D+ H G+ GP G G S I Sbjct: 188 TVFSMDGDIAPLPRLLELAEQHGAWLIVDDAHGFGVLGPQGRGAIAQAALRSPNLISI-- 245 Query: 313 PKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPS 372 GTL K+ G G +VAA +I+W A +IFTT P+ Sbjct: 246 --------------------GTLDKAAGVSGAFVAAHETVIEWLVQRARPYIFTTASVPA 285 Query: 373 VMAGATAAIRYQRC-HIDLRTSQQKHTMYVKKAFHELGIPVIPNPSH--IVPVLIGNADL 429 +A++R D R + + + +A + P +P SH + P++IG D Sbjct: 286 AAHAVSASLRIIGGEEGDARRAHLQQLIGRTRAMLKA-TPWLPVDSHTAVQPLIIGANDA 344 Query: 430 AKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVDDVFNEL 487 + + L ++ ++V AI PTV GT RLRI+ + H+ D L + + + Sbjct: 345 TLEIAATL-DRAGLWVPAIRPPTVPTGTSRLRISLSAAHSQADLDRLEAGLQQLGAKA 401 >6ONN-A nrPDB Length = 402 Score = 375 bits (963), Expect = e-104, Method: Composition-based stats. Identities = 115/417 (27%), Positives = 195/417 (46%), Gaps = 34/417 (8%) Query: 77 IDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPEVLDAM 136 + L++ + R R AH + + + SNDYL L+ HP ++ A+ Sbjct: 11 LLDTLEQGLKEIDARGLRRRRRTVDSPCSAHMTVDGRNMIGFASNDYLGLAAHPLLVAAI 70 Query: 137 HKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHK----KEGALVFSSCYVANDAVLSL 192 + +YG G+GG+ + GH+ LE +LA AL FS+ Y+AN A L+ Sbjct: 71 TEGARRYGAGSGGSHLLGGHSRAHAQLEDDLAEFAGGFVDNPRALYFSTGYMANLATLTA 130 Query: 193 LGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFE 252 L + +FSD LNHAS+I G + + I+ H D L +L++ +V KLI + Sbjct: 131 LAGRGTT--LFSDSLNHASLIDGARLSRADIQIYPHADAEALGAMLEASDAAV-KLIVSD 187 Query: 253 SVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIAT 312 +V+SM G +A + ++ +LA+ +GA +D+ H G+ GP G G S Sbjct: 188 TVFSMDGDIAPLARLLELAEHHGAWLVVDDAHGFGVLGPQGRGAVAEAALRSPHL----- 242 Query: 313 PKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPS 372 ++ GTLGK+ G G +V A +I+W A +IFTT PS Sbjct: 243 -----------------IVVGTLGKAAGVSGAFVVAHETVIEWLVQRARPYIFTTASVPS 285 Query: 373 VMAGATAAIRYQRC-HIDLRTSQQKHTMYVKKAFHELGIPVIPNPSH--IVPVLIGNADL 429 +A++R + R + + + + + + P +P SH + P++IG+ + Sbjct: 286 AAHAVSASLRIIGGDEGEHRRAHLRSLIALTRDMLK-STPWLPVDSHTAVQPLIIGSNEA 344 Query: 430 AKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVDDVFNE 486 + L ++ ++V AI PTV GT RLRI+ + H+++ + L +A+ Sbjct: 345 TLDVAASL-DRANLWVPAIRPPTVPEGTSRLRISLSAAHSHNDLEQLEHALMKTAEA 400 >1DJ9-A nrPDB Length = 384 Score = 357 bits (916), Expect = 8e-99, Method: Composition-based stats. Identities = 103/412 (25%), Positives = 188/412 (45%), Gaps = 34/412 (8%) Query: 71 FDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHP 130 ++ I++ L + + R + + A + +A + + + SNDYL LS HP Sbjct: 1 MSWQEKINAALDARGAADALRRRYPVAQGAGRWLVA----DDRQYLNFSSNDYLGLSHHP 56 Query: 131 EVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVL 190 +++ A + +++G G+GG+ +++G+++ LE ELA AL+F S + AN AV+ Sbjct: 57 QIIRAWQQGAEQFGIGSGGSGHVSGYSVVHQALEEELAEWLGYSRALLFISGFAANQAVI 116 Query: 191 SLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIA 250 + + K+ I +D L+HAS++ + + F HND+ L +LL + P +++ Sbjct: 117 AAM--MAKEDRIAADRLSHASLLEAASLSPSQLRRFAHNDVTHLARLL-ASPCPGQQMVV 173 Query: 251 FESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGI 310 E V+SM G A + +I + ++ +D+ H G+ G G G C + + Sbjct: 174 TEGVFSMDGDSAPLAEIQQVTQQHNGWLMVDDAHGTGVIGEQGRG---SCWLQKVKP--- 227 Query: 311 ATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLP 370 +++ T GK FG G V S + D+ FA I++T++P Sbjct: 228 ------------------ELLVVTFGKGFGVSGAAVLCSSTVADYLLQFARHLIYSTSMP 269 Query: 371 PSVMAGATAAIRYQRC-HIDLRTSQQKHT-MYVKKAFHELGIPVIPNPSHIVPVLIGNAD 428 P+ A++ R D R + + +L + + S I P+++G+ Sbjct: 270 PAQAQALRASLAVIRSDEGDARREKLAALITRFRAGVQDLPFTLADSCSAIQPLIVGDNS 329 Query: 429 LAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAV 480 A Q ++ L + +V I PTV G RLR+T T H D L+ + Sbjct: 330 RALQLAEKL-RQQGCWVTGIRPPTVPAGIARLRLTLTAAHEMQDIDRLLEVL 380 >3HQT-A nrPDB Length = 409 Score = 352 bits (902), Expect = 3e-97, Method: Composition-based stats. Identities = 84/403 (20%), Positives = 172/403 (42%), Gaps = 31/403 (7%) Query: 83 KKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPEVLDAMHKTIDK 142 + ++D + +IN+ K L +Q D + + SNDYLAL+ HP + + K++ + Sbjct: 31 QNKIDHYIENYFDINKNGKHLVLG-KQASPDDIILQ-SNDYLALANHPLIKARLAKSLLE 88 Query: 143 YGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVI 202 + + ++ +E LA + L+ S + AN +L + Q ++ I Sbjct: 89 EQQSLFMSASFLQNDYDKPMIEKRLAKFTGFDECLLSQSGWNANVGLLQTICQPNTNVYI 148 Query: 203 FSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVA 262 D H S+ G ++AN + H F HN+ + L L+Q + P +I +S+YS G++A Sbjct: 149 --DFFAHMSLWEGARYANAQAHPFMHNNCDHLRMLIQRH---GPGIIVVDSIYSTLGTIA 203 Query: 263 DIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAK 322 + ++ +++ ++G +DE H++G +GP+GAG+ Sbjct: 204 PLAELVNISKEFGCALLVDESHSLGTHGPNGAGLLAELGLTR------------------ 245 Query: 323 TVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIR 382 V +T +L K+F G + + ++ + IF++TL P AG + Sbjct: 246 ----EVHFMTASLAKTFAYRAGAIWCNNEVNRCVPFISYPAIFSSTLLPYEAAGLETTLE 301 Query: 383 YQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIVPVLIGNADLAKQASDILINKHQ 442 + R + ++ +LG+ I + S I+ + G+ ++ D L + Sbjct: 302 IIESADNRRQHLDRMARKLRIGLSQLGL-TIRSESQIIGLETGDERNTEKVRDYL-ESNG 359 Query: 443 IYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVDDVFN 485 ++ P ++ +R++ ++ +I D N Sbjct: 360 VFGSVFCRPATSKNKNIIRLSLNSDVNDEQIAKIIEVCSDAVN 402 >5VNX-A nrPDB Length = 393 Score = 314 bits (804), Expect = 6e-86, Method: Composition-based stats. Identities = 124/418 (29%), Positives = 193/418 (46%), Gaps = 34/418 (8%) Query: 77 IDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPEVLDAM 136 + LQ+ D + + R A AH ++ + SNDYL L+ HP+++ A Sbjct: 3 LLDTLQRGLADLDAQGLRRVRRTADSACDAHMTVNGREIVGFASNDYLGLAAHPKLVAAF 62 Query: 137 HKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHK----KEGALVFSSCYVANDAVLSL 192 + +YG G+GG+ + GH+ LE ELA AL FS+ Y+AN A ++ Sbjct: 63 AEGAQRYGSGSGGSHLLGGHSRAHAKLEDELAGFAGGFSDAPRALYFSTGYMANLAAVTA 122 Query: 193 LGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFE 252 L KD IFSD LNHAS+I G + + ++ H D L LL++ S KLI + Sbjct: 123 LAG--KDATIFSDALNHASLIDGTRLSRATVQVYPHADTATLGALLEACT-SQTKLIVTD 179 Query: 253 SVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIAT 312 +V+SM G +A + ++ LA+++GA +D+ H G+ GP G G S Sbjct: 180 TVFSMDGDIAPLAELLALAERHGAWLVVDDAHGFGVLGPQGRGALAAAALRSPHL----- 234 Query: 313 PKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPS 372 + GTLG + G G +V A +I+W A +IFTT PP+ Sbjct: 235 -----------------VYVGTLGXAAGVAGAFVVAHETVIEWLIQRARSYIFTTAAPPA 277 Query: 373 VMAGATAAIRYQRC-HIDLRTSQQKHTMYVKKAFHELGIPVIPNPSH--IVPVLIGNADL 429 V +A+++ D R + + +A P SH + P++IG+ + Sbjct: 278 VAHAVSASLKVIAGDEGDARRAHLAALIERTRALLRRT-RWQPVDSHTAVQPLVIGSNE- 335 Query: 430 AKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVDDVFNEL 487 A A+ ++ H ++V AI PTV GT RLRI+ + H+ D L A+ E Sbjct: 336 ATLAAMRALDAHGLWVPAIRPPTVPAGTSRLRISLSAAHSFDDLARLETALLRASEEA 393 >3WY7-A nrPDB Length = 404 Score = 306 bits (784), Expect = 1e-83, Method: Composition-based stats. Identities = 114/424 (26%), Positives = 182/424 (42%), Gaps = 46/424 (10%) Query: 62 ANHSTQESGFDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSN 121 H +G + Q++R + R +A E LA SN Sbjct: 19 QGHMMTRAGLSPLAWLADIEQRRRAEGLRRELRVRPPVAAELDLA-------------SN 65 Query: 122 DYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSS 181 DYL LS+HP+VLD + + +G GAGG+R + G+ E +LA+ E ALVFSS Sbjct: 66 DYLGLSQHPDVLDGGVEALRTWGGGAGGSRLVTGNTELHEAFEHQLASFLGAESALVFSS 125 Query: 182 CYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSY 241 Y AN L L +I SD L+HAS++ + + + + H D++ ++ L + Sbjct: 126 GYTANLGALVALSGPGS--LIVSDALSHASLVDACRLSRARVVVSPHRDVDAVDAALAAR 183 Query: 242 PKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCD 301 + ++ ESV+S G +A + + + ++GAL +DE H +G+ G G G+ Sbjct: 184 TEERA-VVVTESVFSADGDLAPLRDLHAVCRRHGALLLVDEAHGLGVRGTRGQGLLHEVG 242 Query: 302 FESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAP 361 G VM T TL K+ GS GG V + A Sbjct: 243 L---------------AGAPDIVM------TTTLSKALGSQGGAVLGPEAVRAHLIDTAR 281 Query: 362 GFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNP--SHI 419 FIF T L P+ + A+AA+R Q+ + +A I + S + Sbjct: 282 SFIFDTGLAPAAVGAASAALRVLDAEP------QRARAVLDRAAELATIAGVTEAPVSAV 335 Query: 420 VPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINA 479 V V++G+ ++A A+ +++ + V PTV GT RLR+ T+D + Sbjct: 336 VSVILGDPEIAVGAAAACLDR-GVRVGCFRPPTVPAGTSRLRLAARASLTDDEMALARQV 394 Query: 480 VDDV 483 + DV Sbjct: 395 LTDV 398 >2CFB-A nrPDB Length = 411 Score = 133 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 64/314 (20%), Positives = 100/314 (31%), Gaps = 65/314 (20%) Query: 128 KHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVAND 187 HPEV+DA+H ++K GT A + + E +A + E +S A Sbjct: 53 AHPEVIDALHAALEK------GTSFGAPCLLENILAEMVIAAVPSVEMVRFVNSGTEACM 106 Query: 188 AVLSLL---GQKMKDLVIFSDELNHASMIV-----GI------------KHANVKKHIFK 227 AVL L+ Q+ K + HA M + G+ K Sbjct: 107 AVLRLMRAYTQREKVIKFEGCYHGHADMFLVKAGSGVATLGLPDSPGVPKATTAATLTAP 166 Query: 228 HNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVAD----IEKICDLADKYGALTFLDEV 283 +NDL + +L + YP + +I E V AG + +E + +L +YGAL DEV Sbjct: 167 YNDLEAVSRLFEQYPNDIAGVI-LEPVVGNAGFIPPDAGFLEGLRELTKQYGALLVFDEV 225 Query: 284 HAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGS-- 341 G +G G E TLGK G Sbjct: 226 -MTGFRIAYG-GAQEKFGVTPD--------------------------LTTLGKVIGGGL 257 Query: 342 -VGGYVAASRKLIDWFRSFAPGFIFTT-TLPPSVMAGATAAIRYQRCHIDLRTSQQKHTM 399 VG Y +++ P + T + P M + + T Sbjct: 258 PVGAY-GGRAEIMKMVAPAGPVYQAGTLSGNPLAMTAGIKTLEIL-SRPGSYEHLDRITG 315 Query: 400 YVKKAFHELGIPVI 413 + + + Sbjct: 316 KLVQGLLDAAREFG 329 >4GSA-A nrPDB Length = 432 Score = 114 bits (284), Expect = 1e-25, Method: Composition-based stats. Identities = 63/378 (16%), Positives = 112/378 (29%), Gaps = 87/378 (23%) Query: 78 DSELQKKRLDKSYRYFNNI-------NRLAKEFPLAHRQREADKVTVWCSNDYLAL---- 126 +L + R F ++ +R+ + + ++ DY+ Sbjct: 18 AQKLMPGGVSSPVRAFKSVGGQPIVFDRVKDAY---AWDVDGNRYI-----DYVGTWGPA 69 Query: 127 ---SKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCY 183 HPEV++A+ ++K GT A + + E + E +S Sbjct: 70 ICGHAHPEVIEALKVAMEK------GTSFGAPCALENVLAEMVNDAVPSIEMVRFVNSGT 123 Query: 184 VANDAVLSLL---GQKMKDLVIFSDELNHASMIV-----GI------------KHANVKK 223 A AVL L+ + K + HA M + G+ K Sbjct: 124 EACMAVLRLMRAYTGRDKIIKFEGCYHGHADMFLVKAGSGVATLGLPSSPGVPKKTTANT 183 Query: 224 HIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVAD----IEKICDLADKYGALTF 279 +NDL ++ L P + +I E + +G + +E + ++ ++ AL Sbjct: 184 LTTPYNDLEAVKALFAENPGEIAGVI-LEPIVGNSGFIVPDAGFLEGLREITLEHDALLV 242 Query: 280 LDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSF 339 DEV G +G GV E TLGK Sbjct: 243 FDEV-MTGFRIAYG-GVQEKFGVTPD--------------------------LTTLGKII 274 Query: 340 GS---VGGYVAASRKLIDWFRSFAPGFIFTT-TLPPSVMAGATAAIRYQRCHIDLRTSQQ 395 G VG Y R+++ P + T + P M + R Sbjct: 275 GGGLPVGAY-GGKREIMQLVAPAGPMYQAGTLSGNPLAMTAGIKTLELLR-QPGTYEYLD 332 Query: 396 KHTMYVKKAFHELGIPVI 413 + T + + Sbjct: 333 QITKRLSDGLLAIAQETG 350 >5HDM-A nrPDB Length = 434 Score = 103 bits (256), Expect = 2e-22, Method: Composition-based stats. Identities = 69/387 (17%), Positives = 115/387 (29%), Gaps = 81/387 (20%) Query: 65 STQESGFDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYL 124 S Q+S + L ++ R F ++ P+ + K+ N+Y+ Sbjct: 9 SLQKSEEAFNA--AKNLMPGGVNSPVRAFKSVGGQ----PVLIDSVKGSKMWDIDGNEYI 62 Query: 125 ALS----------KHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKE 174 EVL A+ +T+ K GT A + + E ++ + E Sbjct: 63 DYVGSWGPAIIGHADDEVLAALAETMKK------GTSFGAPCLLENVLAEMVISAVPSIE 116 Query: 175 GALVFSSCYVANDAVLSL---LGQKMKDLVIFSDELNHASMIV-----GI---------- 216 +S A VL L K K + HA+ + G+ Sbjct: 117 MVRFVNSGTEACMGVLRLARAFTNKEKFIKFEGCYHGHANAFLVKAGSGVATLGLPDSPG 176 Query: 217 --KHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEK----ICDL 270 K A +NDL +E+L ++ + +I E V +G + + + L Sbjct: 177 VPKAATSDTLTAPYNDLEAVEKLFAAHKGEISAVI-LEPVVGNSGFIPPTPEFINGLRQL 235 Query: 271 ADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDM 330 G L DEV G +G G E+ Sbjct: 236 TKDNGVLLIFDEV-MTGFRLAYG-GAQEYFGITPD------------------------- 268 Query: 331 ITGTLGKSFGS---VGGYVAASRKLIDWFRSFAPGFIFTT-TLPPSVMAGATAAIRYQRC 386 TLGK G VG Y R +++ P + T + P M ++ + Sbjct: 269 -LTTLGKIIGGGLPVGAY-GGRRDIMEMVAPAGPMYQAGTLSGNPLAMTAGIHTLKRLKQ 326 Query: 387 HIDLRTSQQKHTMYVKKAFHELGIPVI 413 K T + E G Sbjct: 327 AGTY-EYLDKITKELTNGILEAGKKTG 352 >3BS8-A nrPDB Length = 438 Score = 93.0 bits (229), Expect = 3e-19, Method: Composition-based stats. Identities = 79/459 (17%), Positives = 144/459 (31%), Gaps = 94/459 (20%) Query: 78 DSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLA--LSKHPEVL-- 133 +L ++ R F +++ P+ + + K+ N+Y+ LS P +L Sbjct: 22 AQKLMPGGVNSPVRAFKSVDMD----PIFMERGKGSKIFDIDGNEYIDYVLSWGPLILGH 77 Query: 134 --DAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLS 191 D + +++ K GT A + + + + E + SS A + L Sbjct: 78 TNDRVVESLKK--VAEYGTSFGAPTEVENELAKLVIDRVPSVEIVRMVSSGTEATMSALR 135 Query: 192 LL---GQKMKDLVIFSDELNHASMIV----------------GIKHANVK-KHIFKHNDL 231 L + K L H ++ G+ K +NDL Sbjct: 136 LARGYTGRNKILKFEGCYHGHGDSLLIKAGSGVATLGLPDSPGVPEGIAKNTITVPYNDL 195 Query: 232 NELEQLLQSYPKSVPKLIAFESVYSMAGSVAD----IEKICDLADKYGALTFLDEVHAVG 287 ++ Q + + + +I E V G V ++ + D+ ++YG+L DEV Sbjct: 196 ESVKLAFQQFGEDIAGVIV-EPVAGNMGVVPPQEGFLQGLRDITEQYGSLLIFDEV---- 250 Query: 288 LYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVA 347 T D A+ +T LGK G G V Sbjct: 251 -----------------------MTGFRVDYNCAQGYFGVTPDLT-CLGKVIGG-GLPVG 285 Query: 348 ASRKLIDWFRSFAP-GFIFTTTLP---PSVMAGATAAIRYQ--RCHIDLRTSQQKHTMYV 401 A + AP G I+ P M ++ + + + + Sbjct: 286 AYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPDSYKNFIKKGDRLEEGI 345 Query: 402 KKAFHELGIP--VIPNPSHIVPVLIGNADL---AKQASDILI--------NKHQIYVQAI 448 KA GIP S I + +ASD+ + +++ Sbjct: 346 SKAAEAHGIPHTFNRAGSMIGFFFTNEPVINYETAKASDLKLFASYYKGMANEGVFL--- 402 Query: 449 NFPTVARGTERLRITPTPGHTNDLSDILINAVDDVFNEL 487 P+ G + HT++ + I A + VF E+ Sbjct: 403 -PPSQFEGLF-----LSTAHTDEDIENTIQAAEKVFAEI 435 >2E7U-A nrPDB Length = 424 Score = 81.4 bits (199), Expect = 9e-16, Method: Composition-based stats. Identities = 68/435 (15%), Positives = 124/435 (28%), Gaps = 91/435 (20%) Query: 93 FNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSK-HPEVLDAMHKTIDKYGCGAGGTR 151 + A R D V W L L HP+VL + +T+++ G Sbjct: 36 PFLVRGEGAYVWDADGNRYLDYVMSWGP---LILGHAHPKVLARVRETLER------GLT 86 Query: 152 NIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLL---GQKMKDLVIFSDELN 208 A + + + +S A + L L + + + Sbjct: 87 FGAPSPLEVALAKKVKRAYPFVDLVRFVNSGTEATMSALRLARGYTGRPYIVKFRGNYHG 146 Query: 209 HAS----------MIVGIKHANVKKHIFK-------HNDLNELEQLLQSYPKSVPKLIAF 251 HA + +G+ + + +ND L ++L+ + + +I F Sbjct: 147 HADGLLVEAGSGALTLGVPSSAGVPEEYAKLTLVLEYNDPEGLREVLKRRGEEIAAII-F 205 Query: 252 ESVYSMAGSVADIEKICDL---ADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRAS 308 E V AG + E A YG L DEV Sbjct: 206 EPVVGNAGVLVPTEDFLKALHEAKAYGVLLIADEV------------------------- 240 Query: 309 GIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSV--GGYVAASRKLIDWFRSFAPGFIFT 366 + + G + + + D++ TLGK G A R++++ P + Sbjct: 241 -MTGFRLAFGGATELLGLKPDLV--TLGKILGGGLPAAAYAGRREIMEKVAPLGPVYQAG 297 Query: 367 T-TLPPSVMAGATAAIRYQRCHIDLRTSQQ----KHTMYVKKAFHELGIP--VIPNPSHI 419 T + P MA A + + + + +K+ E G+P V S I Sbjct: 298 TLSGNPLAMAAGLATLELLEENPGYYAYLEDLGARLEAGLKEVLKEKGLPHTVNRVGSMI 357 Query: 420 VPVLIGNADLAKQASDIL-----------INKHQIYVQAINFPTVARGTERLRITPTPGH 468 + Q + + IY NF + H Sbjct: 358 TVFFTEGPVVTFQDARRTDTELFKRFFHGLLDRGIYWPPSNFEAA---------FLSVAH 408 Query: 469 TNDLSDILINAVDDV 483 + + + A+ Sbjct: 409 REEDVEKTLEALRKA 423 >5I92-A nrPDB Length = 435 Score = 80.2 bits (196), Expect = 2e-15, Method: Composition-based stats. Identities = 69/457 (15%), Positives = 128/457 (28%), Gaps = 92/457 (20%) Query: 83 KKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSN---DYLA------LSK-HPEV 132 +K + + PL + E V DY+ L HP+V Sbjct: 20 QKHIPGGVNSPVRAFKSVGGTPLFFKHAEGAYVLDEDDKRYVDYVGSWGPMILGHSHPDV 79 Query: 133 LDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSL 192 LDA+ + +D G A + + + + E + SS A + + L Sbjct: 80 LDAVRRQLDH------GLSYGAPTALEVEMADLVCSMVPSMEMVRMVSSGTEATMSAIRL 133 Query: 193 L---GQKMKDLVIFSDELNHASMIV----------------GIKHANVK-KHIFKHNDLN 232 + + H+ ++ G+ A K ND+ Sbjct: 134 ARGYTGRDSIIKFEGCYHGHSDSLLVKAGSGALTFGVPNSPGVPAAFAKHTLTLPFNDIE 193 Query: 233 ELEQLLQSYPKSVPKLIAFESVYSMAGSVAD----IEKICDLADKYGALTFLDEVHAVGL 288 + + L K V +I E V V +E + + D++G + DEV G Sbjct: 194 AVRKTLGEVGKEVACIIV-EPVAGNMNCVPPAPGFLEGLREACDEHGVVLIFDEV-MTGF 251 Query: 289 YGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAA 348 G G + ++ GA + LG + G ++ Sbjct: 252 RVALG-GAQAYYGVTPDLSTFGKIIGGGMPVGAFGGKREIMQQISPLGPVY--QAGTLSG 308 Query: 349 SRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRC---HIDLRTSQQKHTMYVKKAF 405 + P MA +R H +L + +++ Sbjct: 309 N---------------------PLAMAAGLTTLRLISRPGFHDELTAYTTRMLDGLQQRA 347 Query: 406 HELGIPVIPNP---------SHIVPVLIGNADLAKQASD-----ILINKHQIYVQAINFP 451 GIP + S ++ +A L+ +Y+ Sbjct: 348 DAAGIPFVTTQAGGMFGLYFSGADAIVTFEDVMASDVERFKRFFHLMLDGGVYLA---PS 404 Query: 452 TVARGTERLRITPTPGHTNDLSDILINAVDDVFNELQ 488 G + H + +I +NA + F L+ Sbjct: 405 AFEAGFT------SIAHGDKELEITLNAAEKAFAALK 435 >4E77-A nrPDB Length = 429 Score = 77.9 bits (190), Expect = 1e-14, Method: Composition-based stats. Identities = 31/180 (17%), Positives = 62/180 (34%), Gaps = 31/180 (17%) Query: 128 KHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVAND 187 HP + A+ + +++ G A + + + + + +S A Sbjct: 70 NHPAIRQAVIEAVER------GLSFGAPTEMEVKMAQLVTDLVPTMDMVRMVNSGTEATM 123 Query: 188 AVLSLL---GQKMKDLVIFSDELNHASMIV----------------GIKHANVK-KHIFK 227 + + L + K + HA ++ G+ K Sbjct: 124 SAIRLARGYTGRDKIIKFEGCYHGHADCLLVKAGSGALTLGQPNSPGVPTDFAKHTLTCT 183 Query: 228 HNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEK----ICDLADKYGALTFLDEV 283 +NDL + Q + YP+ V +I E V + + + + L D++GAL +DEV Sbjct: 184 YNDLASVRQAFEQYPQEVACIIV-EPVAGNMNCIPPLPEFLPGLRALCDEFGALLIIDEV 242 >3K28-A nrPDB Length = 429 Score = 77.5 bits (189), Expect = 1e-14, Method: Composition-based stats. Identities = 68/374 (18%), Positives = 118/374 (31%), Gaps = 80/374 (21%) Query: 78 DSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLA--LSKHP----- 130 +L ++ R F ++ PL + + KV N+Y+ LS P Sbjct: 14 AQDLMPGGVNSPVRAFKSVGMN----PLFMERGKGSKVYDIDGNEYIDYVLSWGPLIHGH 69 Query: 131 ---EVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVAND 187 V++A+ ++ GT A I + + + E + +S A Sbjct: 70 ANDRVVEALKAVAER------GTSFGAPTEIENKLAKLVIERVPSIEIVRMVNSGTEATM 123 Query: 188 AVLSLL---GQKMKDLVIFSDELNHASMIV----------------GIKHANVK-KHIFK 227 + L L + K L H ++ G+ K Sbjct: 124 SALRLARGYTGRNKILKFIGCYHGHGDSLLIKAGSGVATLGLPDSPGVPEGVAKNTITVA 183 Query: 228 HNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVAD----IEKICDLADKYGALTFLDEV 283 +NDL ++ + + + +I E V G V +E + ++ ++ GAL DEV Sbjct: 184 YNDLESVKYAFEQFGDDIACVIV-EPVAGNMGVVPPQPGFLEGLREVTEQNGALLIFDEV 242 Query: 284 HAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVG 343 G VA +C + + T LGK G G Sbjct: 243 -MTGFR------VAYNCGQGYYGVTPDLTC---------------------LGKVIGG-G 273 Query: 344 GYVAASRKLIDWFRSFAP-GFIFTTTLP---PSVMAGATAAIRYQ--RCHIDLRTSQQKH 397 V A + R AP G I+ P MA + +++ + Sbjct: 274 LPVGAYGGKAEIMRQVAPSGPIYQAGTLSGNPLAMAAGYETLVQLTPESYVEFERKAEML 333 Query: 398 TMYVKKAFHELGIP 411 ++KA + GIP Sbjct: 334 EAGLRKAAEKHGIP 347 >1YJS-A nrPDB Length = 419 Score = 69.5 bits (168), Expect = 4e-12, Method: Composition-based stats. Identities = 63/370 (17%), Positives = 114/370 (30%), Gaps = 50/370 (13%) Query: 142 KYGCGAGGTRNIAGHNIPTLNLE---AELATLHKKEGALVF-SSCYVANDAVLSLLGQKM 197 KY G G R G + E L E A V S AN AV + + Sbjct: 50 KYAEGYPGRRYYGGCEYVDIVEELARERAKQLFGAEHANVQPHSGAQANMAVYFTVLEHG 109 Query: 198 KDLV----IFSDELNHASMIV--GIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAF 251 ++ L H S + G+++ V + + + + + + PKLI Sbjct: 110 DTVLGMNLSHGGHLTHGSPVNFSGVQYNFVAYGVDPETHVIDYDDVREKARLHRPKLIVA 169 Query: 252 ESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIA 311 + S + D K ++AD+ GA +D H GL AG+ + + Sbjct: 170 AA--SAYPRIIDFAKFREIADEVGAYLMVDMAHIAGLV---AAGLHPNPVPYA------- 217 Query: 312 TPKTNDKGGAKTVMDRVDMITGTLGKSF-GSVGGYVAASRKLIDWFRSFAPGFIFTTTLP 370 +T T ++ G GG + + I L Sbjct: 218 -----------------HFVTTTTHQTLRGPRGGMILCQEQFAKQIDKAIFPGIQGGPLM 260 Query: 371 PSVMAGATAAIRYQRCHIDL-RTSQQKHTMYVKKAFHELGIPV--IPNPSHIVPVLIGNA 427 + A A A + + + A G + +H++ V + Sbjct: 261 HVIAAKAVAFGEALQDDFKAYAKRVVDNAKRLASALQNEGFTLVSGGTDNHLLLVDLRPQ 320 Query: 428 DLAKQASDILINKHQIYV--QAINF-PTVARGTERLRITPTPGHT----NDLSDILINAV 480 L + ++ ++++ I V I + P T +RI T + D + + Sbjct: 321 QLTGKTAEKVLDEVGITVNKNTIPYDPESPFVTSGIRIGTAAVTTRGFGLEEMDEIAAII 380 Query: 481 DDVFNELQLP 490 V + Sbjct: 381 GLVLKNVGSE 390 >2EPJ-A nrPDB Length = 434 Score = 69.1 bits (167), Expect = 5e-12, Method: Composition-based stats. Identities = 55/291 (18%), Positives = 94/291 (32%), Gaps = 68/291 (23%) Query: 128 KHPEVLDAMHKTIDK-YGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVAN 186 KHP VL+A+ + + + + GA G + L E L + + +S A Sbjct: 73 KHPRVLEAVEEALARGWLYGAPGEAEV-------LLAEKILGYVKRGGMIRFVNSGTEAT 125 Query: 187 DAVLSLL---GQKMKDLVIFSDEL-NHASMIVGIKHANVK----------------KHIF 226 + L + L +H +++V A + Sbjct: 126 MTAIRLARGYTGRDLILKFDGCYHGSHDAVLVAAGSAAAHYGVPTSAGVPEAVARLTLVT 185 Query: 227 KHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVAD----IEKICDLADKYGALTFLDE 282 +ND+ LE++ Y + +I E V + AG + + + L+ + GAL LDE Sbjct: 186 PYNDVEALERVFAEYGDRIAGVIV-EPVIANAGVIPPRREFLAALQRLSRESGALLILDE 244 Query: 283 VHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSV 342 V + + +G D+I LGK G Sbjct: 245 V--------------------------VTGFRLGLEGAQGYFNIEGDIIV--LGKIIGGG 276 Query: 343 --GGYVAASRKLIDWFRSFAPGFIFTTT---LPPSVMAGATAAIRYQRCHI 388 G VA SR+++ G +F P MA A ++ Sbjct: 277 FPVGAVAGSREVMSLL--TPQGKVFNAGTFNAHPITMAAGLATLKALEEEP 325 >4OTL-A nrPDB Length = 423 Score = 66.0 bits (159), Expect = 5e-11, Method: Composition-based stats. Identities = 76/435 (17%), Positives = 142/435 (32%), Gaps = 64/435 (14%) Query: 87 DKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPEVLDA-MHKTIDKYGC 145 D++ N++ +R+ D + + S +Y P V+ A + +KY Sbjct: 11 DRAQSTIANVDPEIFAAIEQENRRQEDHIELIASENY----TSPAVMAAQGSQLTNKYAE 66 Query: 146 GAGGTRNIAGHNIP---TLNLEAELATLHKKEGALVF-SSCYVANDAVLSLLGQKMKDLV 201 G G R G + L E A V +S AN V + + ++ Sbjct: 67 GYPGKRYYGGCEYVDVVEQLAIDRVKQLFGAEAANVQPNSGSQANQGVFFAMLKPGDTIM 126 Query: 202 IFSDELN----HASMIV--GIKHANVKKHIFKHNDLNELE--QLLQSYPKSVPKLIAFES 253 S H S + G + N+ +++ + + PKLI + Sbjct: 127 GMSLAHGGHLTHGSPVNMSGKWFN---VVSYGLNENEDIDYDAAEKLANEHKPKLIVAGA 183 Query: 254 VYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATP 313 S D E++ +A GA +D H GL AGV + + Sbjct: 184 --SAFALKIDFERLAKIAKSVGAYLMVDMAHYAGLI---AAGVYPNPVPHA--------- 229 Query: 314 KTNDKGGAKTVMDRVDMITGTLGKSF-GSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPS 372 D +T T KS G GG + + S I L Sbjct: 230 ---------------DFVTTTTHKSLRGPRGGVILMKAEYEKPINSAIFPGIQGGPLMHV 274 Query: 373 VMAGATAAIRYQRCH-IDLRTSQQKHTMYVKKAFHELGIPV--IPNPSHIVPVLIGNADL 429 + A A A + + ++ + + + G+ + SH++ V + + Sbjct: 275 IAAKAVAFKEALSPEFKEYQQKVVENARVLAETLVKRGLRIVSGRTESHVMLVDLRAKHI 334 Query: 430 AKQASDILINKHQIYV--QAI-NFPTVARGTERLRI--------TPTPGHTNDLSDILIN 478 +A++ + I V AI N P T +R+ P + +++ + Sbjct: 335 TGKAAEAALGAAHITVNKNAIPNDPEKPFVTSGIRLGSPAMTTRGFGPAEAEQVGNLIAD 394 Query: 479 AVDDVFNELQLPRVR 493 +++ + + RVR Sbjct: 395 VLENPEDAATIERVR 409 >3L44-A nrPDB Length = 434 Score = 65.6 bits (158), Expect = 6e-11, Method: Composition-based stats. Identities = 67/468 (14%), Positives = 132/468 (28%), Gaps = 105/468 (22%) Query: 79 SELQKKRLDKSYRYFNNINR----LAKEFPLAHRQREADKVTVWCSN---DYLAL----- 126 L K+ L+ N+ +R + P+A + + N DYLA Sbjct: 9 EALHKEALEHIVGGVNSPSRSFKAVGGGAPIAMERGKGAYFWDVDGNKYIDYLAAYGPII 68 Query: 127 --SKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYV 184 HP + A+ + G + + + + +S Sbjct: 69 TGHAHPHITKAITTAAE------NGVLYGTPTALEVKFAKMLKEAMPALDKVRFVNSGTE 122 Query: 185 ANDAVLS---LLGQKMKDLVIFSDELNHASMIV----------------GIKHANVK-KH 224 A + + K + H+ +++ G+ + + Sbjct: 123 AVMTTIRVARAYTGRTKIMKFAGCYHGHSDLVLVAAGSGPSTLGTPDSAGVPQSIAQEVI 182 Query: 225 IFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVAD----IEKICDLADKYGALTFL 280 N++ L++ L + V ++ E + G V +EK+ +L + GAL Sbjct: 183 TVPFNNVETLKEALDKWGHEVAAILV-EPIVGNFGIVEPKPGFLEKVNELVHEAGALVIY 241 Query: 281 DEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFG 340 DEV I + G + D+ LGK G Sbjct: 242 DEV--------------------------ITAFRFMYGGAQDLLGVTPDL--TALGKVIG 273 Query: 341 S---VGGYVAASRKLIDWFRSFAPGF-IFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQK 396 +G Y +++++ P + T P+ MA A + + L + Sbjct: 274 GGLPIGAY-GGKKEIMEQVAPLGPAYQAGTMAGNPASMASGIACLEVLQQEG-LYEKLDE 331 Query: 397 HTMYVKKAF------HELGIPVIPNPSHIVPVLIGNADLAKQASD-----------ILIN 439 ++K H + I + + N A+ L+ Sbjct: 332 LGATLEKGILEQAAKHNIDITLNRLKGALTVYFTTNTIEDYDAAQDTDGEMFGKFFKLML 391 Query: 440 KHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVDDVFNEL 487 + + + + T HT + + I AV F L Sbjct: 392 QEGVNLAPSKYEA---------WFLTTEHTKEDIEYTIEAVGRAFAAL 430 >4P3M-A nrPDB Length = 429 Score = 64.1 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 74/385 (19%), Positives = 129/385 (33%), Gaps = 59/385 (15%) Query: 105 LAHRQREADKVTVWCSNDYLALSKHPEVLDA-MHKTIDKYGCGAGGTRNIAGHNI----P 159 QR+ D + + S +Y P V++A + +KY G G R G Sbjct: 20 TDEVQRQEDHIELIASENY----TSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEYVDVAE 75 Query: 160 TLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDEL-------NHASM 212 +L +E + + S AN AV L ++ S +H S Sbjct: 76 SLAIERAKSLFGADYANVQPHSGSQANAAVYQALCAPGDTILGMSLAHGGHLTHGSHVS- 134 Query: 213 IVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLAD 272 G + V+ I + + ++ + + P +I +S + D K ++AD Sbjct: 135 FSGKMYNAVQYGITPETGILDYAEIERLAVEHKPTMIIAG--FSAYSGIVDWAKFREIAD 192 Query: 273 KYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMIT 332 K GA F+D H GL AG+ + + D++T Sbjct: 193 KVGAYLFVDMAHVAGLV---AAGLYPNPVPFA------------------------DVVT 225 Query: 333 GTLGKSFGS-VGGYVAASRKLIDWFRSFAPGFIFTTTL-PPSVMAGATAAIRYQRCHIDL 390 T K+ G GG + A + +F P + A A+ ++ C Sbjct: 226 TTTHKTLGGPRGGLILAKA--NEAIEKKLNSAVFPGQQGGPLMHVIAAKAVAFKECAEPE 283 Query: 391 RTSQQK----HTMYVKKAFHELGIPV--IPNPSHIVPVLIGNADLAKQASDILINKHQIY 444 Q+ + + K+F G + +H+ V + D+ + +D + I Sbjct: 284 FAVYQQQVLDNAKAMVKSFLARGYKIVSGGTENHLFLVDLIAQDITGKEADAALGNAHIT 343 Query: 445 VQAINFPTVARG---TERLRITPTP 466 V + P R T LRI Sbjct: 344 VNKNSVPNDPRSPFVTSGLRIGTPA 368 >1M6S-A nrPDB Length = 347 Score = 64.1 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 54/341 (15%), Positives = 113/341 (33%), Gaps = 53/341 (15%) Query: 162 NLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIV-GIKHAN 220 LE A KE AL S + N + Q+ ++++ +D +H G Sbjct: 42 ELERLAAETFGKEAALFVPSGTMGNQVSIMAHTQRGDEVILEAD--SHIFWYEVGAMAVL 99 Query: 221 VKKHIFK------HNDLNELEQLLQSYPKSVPK--LIAFESVYSMAGS-VADIE---KIC 268 D +++ + ++ P+ LIA E+ ++ +G V +E +IC Sbjct: 100 SGVMPHPVPGKNGAMDPDDVRKAIRPRNIHFPRTSLIAIENTHNRSGGRVVPLENIKEIC 159 Query: 269 DLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRV 328 +A ++G +D + + P G A +VM Sbjct: 160 TIAKEHGINVHIDGARIF------------------NASIASGVPVKEYAGYADSVMFC- 200 Query: 329 DMITGTLGKSF-GSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCH 387 L K VG V R I+ R+ + + + + A I + Sbjct: 201 ------LSKGLCAPVGSVVVGDRDFIE--RARKARKMLGGGMRQAGVLAAAGIIALTKMV 252 Query: 388 IDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIVPVLIGNADLAKQASDIL--INKHQIYV 445 L+ ++ ++ E+G V P V++ +L A + + + Sbjct: 253 DRLKEDH-ENARFLALKLKEIGYSVNPEDVKTNMVILRTDNLKVNAHGFIEALRNSGVLA 311 Query: 446 QAINFPTVARGTERLRITPTPGHTNDLSDILINAVDDVFNE 486 A++ +R+ + + + +N + +F + Sbjct: 312 NAVS-------DTEIRLVTHKDVSRNDIEEALNIFEKLFRK 345 >3G8M-A nrPDB Length = 417 Score = 62.1 bits (149), Expect = 6e-10, Method: Composition-based stats. Identities = 75/418 (17%), Positives = 140/418 (33%), Gaps = 67/418 (16%) Query: 107 HRQREADKVTVWCSNDYLALSKHPEVLDA-MHKTIDKYGCGAGGTRNIAGHNIP---TLN 162 + R+ + + + S +Y P V+ A + +K+ G G R G Sbjct: 22 EKVRQEEHIELIASENY----TSPRVMQAQGSQLTNKFAEGYPGKRYYGGCEYVDIVEQL 77 Query: 163 LEAELATLHKKEGALVF-SSCYVANDAVLSLLGQKMKDLVIFSDELNHAS-MIVGIKHAN 220 L + A V S AN AV + L + L H + G Sbjct: 78 AIDRAKELFGADYANVQPHSGSQANFAVYTAL--LEPGDTVLGMNLAHGGHLTHGSPVNF 135 Query: 221 V----KKHIFKHNDLNELE--QLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKY 274 + + ++ L + + PK+I +S V D K+ ++AD Sbjct: 136 SGKLYNIVPYGIDATGHIDYADLEKQAKEHKPKMII--GGFSAYSGVVDWAKMREIADSI 193 Query: 275 GALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTN-DKGGAKTVMDRVDMITG 333 GA F+D H GL AGV + +H + +GG + + Sbjct: 194 GAYLFVDMAHVAGLV---AAGVYPNPVPHAHVVTTTTHKTLAGPRGGLILAKGGSEELYK 250 Query: 334 TLGKSF--GSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLR 391 L + G GG + V+AG A++ + + Sbjct: 251 KLNSAVFPGGQGG-----------------PLMH-------VIAGKAVALKEAM-EPEFK 285 Query: 392 TSQQ---KHTMYVKKAFHELGIPV--IPNPSHIVPVLIGNADLAKQASDILINKHQIYVQ 446 T QQ K+ + + F E G V +H+ V + + +L + +D + + I V Sbjct: 286 TYQQQVAKNAKAMVEVFLERGYKVVSGGTDNHLFLVDLVDKNLTGKEADAALGRANITVN 345 Query: 447 AINFPTVARG---TERLRITPTP--------GHTNDLSDILINAVDDVFNELQLPRVR 493 + P + T +R+ +L+ + + +D + +E + R++ Sbjct: 346 KNSVPNDPKSPFVTSGIRVGTPAITRRGFKEAEAKELAGWMCDVLDSINDEAVIERIK 403 >4AOA-A nrPDB Length = 454 Score = 60.2 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 72/403 (17%), Positives = 122/403 (30%), Gaps = 54/403 (13%) Query: 52 THAAAAAAAAANH-----STQESGFDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLA 106 THAA A A + + S +E + + E A Sbjct: 22 THAAIDQALADAYRRFTDANPASQRQFEAQARYMPGANSRSVLFYAPFPLTIARGEGA-A 80 Query: 107 HRQREADKVTVWCSNDYLALSKH--PEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLE 164 + + + + + H PE+ DA+ + + G N+ G LE Sbjct: 81 LWDADGHRYADFIAEYTAGVYGHSAPEIRDAVIEAMQ-------GGINLTG----HNLLE 129 Query: 165 AELAT-----LHKKEGALVFSSCYVANDAVLSLL--GQKMKDLVIFSDELNHASMIVGIK 217 LA + E +S AN L+ + +V+FS + + G + Sbjct: 130 GRLARLICERFPQIEQLRFTNSGTEANLMALTAALHFTGRRKIVVFSGGYHGGVLGFGAR 189 Query: 218 HANVKK----HIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVAD----IEKICD 269 + + +ND ++ + + ++ E + +G + ++ + + Sbjct: 190 PSPTTVPFDFLVLPYNDAQTARAQIERHGPEIA-VVLVEPMQGASGCIPGQPDFLQALRE 248 Query: 270 LADKYGALTFLDEVHAVGLYGPHGAG--VAEHCDFESHRASGIATPKTNDKGGAKTVMDR 327 A + GAL DEV PHG + D + GG VM Sbjct: 249 SATQVGALLVFDEV-MTSRLAPHGLANKLGIRSDLTTLGKYIGGGMSFGAFGGRADVMAL 307 Query: 328 VDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCH 387 D TG L S + + A G+ T L AGA A Sbjct: 308 FDPRTGPLAHS-----------GTFNNNVMTMAAGYAGLTKLFTPEAAGALA-----ERG 351 Query: 388 IDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIVPVLIGNADLA 430 LR A GI + N + + + DLA Sbjct: 352 EALRARLNALCANEGVAMQFTGIGSLMNAHFVQGDVRSSEDLA 394 >3GBX-A nrPDB Length = 420 Score = 60.2 bits (144), Expect = 2e-09, Method: Composition-based stats. Identities = 73/420 (17%), Positives = 137/420 (32%), Gaps = 71/420 (16%) Query: 107 HRQREADKVTVWCSNDYLALSKHPEVLDA-MHKTIDKYGCGAGGTRNIAGHNIP---TLN 162 + R+ + + + S +Y P V+ A + +KY G G R G Sbjct: 25 EKVRQEEHIELIASENY----TSPRVMQAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQL 80 Query: 163 LEAELATLHKKEGALVF-SSCYVANDAVLSLLGQKMKDLV----IFSDELNHAS------ 211 L + A V S AN AV + L Q ++ L H S Sbjct: 81 AIDRAKELFGADYANVQPHSGSQANFAVYTALLQPGDTVLGMNLAQGGHLTHGSPVNFSG 140 Query: 212 -MIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDL 270 + + + + ++++ +L + + PK+I +S V D K+ ++ Sbjct: 141 KLYNIVPYGIDESGKIDYDEMAKLAK------EHKPKMII--GGFSAYSGVVDWAKMREI 192 Query: 271 ADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDM 330 AD GA F+D H GL AGV + +H + Sbjct: 193 ADSIGAYLFVDMAHVAGLI---AAGVYPNPVPHAHVVTTTTHKTL--------------- 234 Query: 331 ITGTLGKSFGSVGGYVAA---SRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCH 387 G GG + A +L S L + A A Sbjct: 235 --------AGPRGGLILAKGGDEELYKKLNSAVFPSAQGGPLMHVIAGKAVALKEAMEPE 286 Query: 388 IDL-RTSQQKHTMYVKKAFHELGIPV--IPNPSHIVPVLIGNADLAKQASDILINKHQIY 444 + + K+ + + F G V +H+ + + + +L + +D + + I Sbjct: 287 FKVYQQQVAKNAKAMVEVFLNRGYKVVSGGTENHLFLLDLVDKNLTGKEADAALGRANIT 346 Query: 445 VQAINFPTVARG---TERLRITPTP--------GHTNDLSDILINAVDDVFNELQLPRVR 493 V + P + T +RI +L+ + + +D++ +E + RV+ Sbjct: 347 VNKNSVPNDPKSPFVTSGIRIGSPAVTRRGFKEAEVKELAGWMCDVLDNINDEATIERVK 406 >4ADC-A nrPDB Length = 406 Score = 56.7 bits (135), Expect = 2e-08, Method: Composition-based stats. Identities = 48/297 (16%), Positives = 92/297 (30%), Gaps = 53/297 (17%) Query: 93 FNNINRLAKEFPLAHRQREADKVTVWCSN---DYLALSKHPEVLDAMHKTIDKYGCGAGG 149 F + ++ + + + L + HPE+ +A+++ K+ Sbjct: 23 FIPVRGEGSRL----WDQQGKEYIDFAGGIAVNALGHA-HPELREALNEQASKFW----- 72 Query: 150 TRNIAGHNIPTL-NLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELN 208 G+ + L +L + +S AN+A L L +K + Sbjct: 73 -HTGNGYTNEPVLRLAKKLIDATFADRVFFCNSGAEANEAALK-LARKFAHDR----YGS 126 Query: 209 HASMIVGIKHA------------------------NVKKHIFKHNDLNELEQLLQSYPKS 244 H S IV K+A +ND+N L+ + Sbjct: 127 HKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPLPADIRHAAYNDINSASALIDDSTCA 186 Query: 245 VPKLIAFESVYSMAGSVAD----IEKICDLADKYGALTFLDEVH-AVGLYGPHGAGVAEH 299 + E + G V ++ + +L +++ AL DEV VG G A + Sbjct: 187 ----VIVEPIQGEGGVVPASNAFLQGLRELCNRHNALLIFDEVQTGVGRTGELYAYMHYG 242 Query: 300 CDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWF 356 + + T M GT G ++G A + K+++ Sbjct: 243 VTPDLLTTAKALGGGFPVGALLATEECARVMTVGTHGTTYGGNPLASAVAGKVLELI 299 >1VJO-A nrPDB Length = 393 Score = 56.4 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 56/335 (16%), Positives = 113/335 (33%), Gaps = 58/335 (17%) Query: 178 VFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHN-----DLN 232 V + A +A ++ + ++I ++ L Sbjct: 90 VSGTGTAAMEATIANAVEPGDVVLIGVAGYFGNRLVDMAGRYGADVRTISKPWGEVFSLE 149 Query: 233 ELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVG----L 288 EL L+++ ++ L+ E+ G+ +E + +L ++G L +D V ++G Sbjct: 150 ELRTALETHRPAILALVHAET---STGARQPLEGVGELCREFGTLLLVDTVTSLGGVPIF 206 Query: 289 YGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMI------TGTLGKSFGSV 342 G +A C + S A+P T + + R + LGK +GS Sbjct: 207 LDAWGVDLAYSCSQKGLGCSPGASPFTMSSRAIEKLQRRRTKVANWYLDMNLLGKYWGSE 266 Query: 343 GGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHI--DLRTSQQKHTMY 400 ++ T P ++ A+R + QK+ Y Sbjct: 267 --------------------RVYHHTAPINLYYALREALRLIAQEGLANCWQRHQKNVEY 306 Query: 401 VKKAFHELGIPVIPNPSHIVP----VLIGNADLAKQASDILINKHQIYVQAINFPTVARG 456 + + ++G+ + + +P V I + K + L+N+H I V G Sbjct: 307 LWERLEDIGLSLHVEKEYRLPTLTTVCIPDGVDGKAVARRLLNEHNIEVGG--------G 358 Query: 457 TERL-----RITPTPGHT-NDLSDILINAVDDVFN 485 L R+ ++ + D LI A++ V Sbjct: 359 LGELAGKVWRVGLMGFNSRKESVDQLIPALEQVLR 393 >2DKJ-A nrPDB Length = 407 Score = 56.4 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 68/380 (17%), Positives = 124/380 (32%), Gaps = 61/380 (16%) Query: 142 KYGCGAGGTRNIAGHNI----PTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKM 197 KY G G R G + +L +E A + S AN AV L + Sbjct: 50 KYAEGYPGARYYGGCEVIDRVESLAIERAKALFGAAWANVQPHSGSQANMAVYMALMEPG 109 Query: 198 KDLV-IFSDELNHASMIVGIKHANV----KKHIF---KHNDLNELEQLLQSYPKSVPKLI 249 L+ + H + G + K + +L +LE++ + + PK+I Sbjct: 110 DTLMGMDLAAGGH--LTHGSRVNFSGKLYKVVSYGVRPDTELIDLEEVRRLALEHRPKVI 167 Query: 250 AFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASG 309 + S D + ++AD+ GA +D H GL AG+ + Sbjct: 168 VAGA--SAYPRFWDFKAFREIADEVGAYLVVDMAHFAGLV---AAGLHPNP--------- 213 Query: 310 IATPKTNDKGGAKTVMDRVDMITGTLGKSF-GSVGGYVAASRK----LIDWFRSFAPGFI 364 + ++T T K+ G GG + ++ ID I Sbjct: 214 ---------------LPYAHVVTSTTHKTLRGPRGGLILSNDPELGKRIDKLIF---PGI 255 Query: 365 FTTTLPPSVMAGATAAIRYQRCHIDLRTSQ-QKHTMYVKKAFHELGIPVIP--NPSHIVP 421 L + A A + + ++ + + G ++ +H+ Sbjct: 256 QGGPLEHVIAGKAVAFFEALQPEFKEYSRLVVENAKRLAEELARRGYRIVTGGTDNHLFL 315 Query: 422 VLIGNADLAKQASDILINKHQIYV--QAINF-PTVARGTERLRITPTP----GHTNDLSD 474 V + L + ++ ++ I V AI F P R T +RI G T + Sbjct: 316 VDLRPKGLTGKEAEERLDAVGITVNKNAIPFDPKPPRVTSGIRIGTPAITTRGFTPEEMP 375 Query: 475 ILINAVDDVFNELQLPRVRD 494 ++ +D E +R+ Sbjct: 376 LVAELIDRALLEGPSEALRE 395 >4J5U-A nrPDB Length = 420 Score = 56.4 bits (134), Expect = 4e-08, Method: Composition-based stats. Identities = 72/397 (18%), Positives = 129/397 (32%), Gaps = 58/397 (14%) Query: 92 YFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPEVLDAMHKTI-DKYGCGAGGT 150 + ++ E + R++ + + S ++++ P VL+A + +KY G Sbjct: 7 NLHETDKEINEIIKHEKLRQSSVIELIASENFVS----PAVLEAQGALLTNKYAEGYPSK 62 Query: 151 RNIAGHNI----PTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFS-D 205 R G L +E + K + S AN AV L Q ++ S D Sbjct: 63 RFYNGCEEVDKAENLAIERVKKLFNCKYANVQPHSGSQANQAVYLALLQPGDTVLGMSLD 122 Query: 206 ELNH-----ASMIVGIKHANVKKHIFKHN---DLNELEQLLQSYPKSVPKLIAFESVYSM 257 H A + G V + K D +E+E+L + + LIA S Y Sbjct: 123 SGGHLTHGAAPNMSGKWFNAVSYSVNKETYLIDYDEIERLADLHKPKL--LIAGFSAYPR 180 Query: 258 AGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTND 317 A +I D K GA D H GL Sbjct: 181 NIDFAKFREIVD---KVGAYFMADIAHIAGLV---------------------------A 210 Query: 318 KGGAKTVMDRVDMITGTLGKSF-GSVGGYVAASRKLIDWFRSFA-PGFIFTTTLPPSVMA 375 G ++ + +T T K+ G GG + ++ + I + A + L + A Sbjct: 211 TGEHQSPIPYAHAVTSTTHKTLRGPRGGLILSNDEEIGHKINSALFPGLQGGPLMHIIAA 270 Query: 376 GATAAIRYQRCHIDL-RTSQQKHTMYVKKAFHELGIPVIP--NPSHIVPVLIGNADLAKQ 432 A A + + + + + E G ++ +HIV V + + + Sbjct: 271 KAVAFLENLQPEYKSYIQQVISNAKALASSLQERGYDILTGGTDNHIVLVDLRKDGITGK 330 Query: 433 ASDILINKHQIYVQAINFP---TVARGTERLRITPTP 466 + +++ I P T T +R+ Sbjct: 331 LAANSLDRAGITCNKNAIPFDETSPFITSGIRLGTPA 367 >5YKR-A nrPDB Length = 461 Score = 56.0 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 61/317 (19%), Positives = 106/317 (33%), Gaps = 57/317 (17%) Query: 111 EADKVTVWCSNDYLALSKH--PEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELA 168 + + + D A+ H P V DA+ + + G+ + L + AELA Sbjct: 73 DGQQYVDFALGDSGAMFGHAQPAVADAIARQARR------GSTLMLPTEDS-LWVGAELA 125 Query: 169 TLHKKEGALVFSSCYVANDAVLSL--LGQKMKDLVIFSDELNHASMIV------------ 214 V +S AN VL L + +V+F+ H S+ Sbjct: 126 RRFGLPYWQVTTSATDANRFVLRLCRMLSGRDKVVVFNCNY-HGSVDESQVEFDAAGRMV 184 Query: 215 --------GIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEK 266 G++HA + + + NDL+ LE L + + E + G V E Sbjct: 185 PRAGVHPNGVRHATTTRLV-EFNDLDALEAALAHGDVAA---VLTEPFMTNVGMVPPAEG 240 Query: 267 ----ICDLADKYGALTFLDEVH--AVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGG 320 + +L ++ +DE H + G G GA E F + P G Sbjct: 241 FHAGLRELTRRHDVALIIDETHTISCGPAGYSGAHGLEPDFFVLGKCIAGGIPSAVW-GC 299 Query: 321 AKTVMDRVDMITGTL--GKSFG--SVGGYVAAS--------RKLIDWFRSFAPGFIFTTT 368 ++ +R+ + G++ GG +A + + A +F Sbjct: 300 SQAQAERIWAVLPHFRPGQAINHFGFGGTLAGNALQLAAMRATFAEVMTEDAYRHMF--Q 357 Query: 369 LPPSVMAGATAAIRYQR 385 L + AG A + R Sbjct: 358 LAAQLEAGVRATLEELR 374 >2E54-A nrPDB Length = 385 Score = 54.4 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 59/422 (13%), Positives = 115/422 (27%), Gaps = 91/422 (21%) Query: 103 FPLAHRQREADKVTVWCSNDYLALSK----------HPEVLDAMHKTIDKYGCGAGGTRN 152 FP + + N YL + HP +++A+ +K Sbjct: 10 FPATFVYGKGSWIYDEKGNAYLDFTSGIAVNVLGHSHPRLVEAIKDQAEK---------L 60 Query: 153 IAGHNIPTLNLEAELATLHKKE----GALVFSSCYVANDAVLSL----LGQKMKDLVIFS 204 I N+ + ELA L K ++ AN+A + + +K + Sbjct: 61 IHCSNLFWNRPQMELAELLSKNTFGGKVFFANTGTEANEAAIKIARKYGKKKSEKKYRIL 120 Query: 205 DELN--HASMIVGIKHANVKKHI------------FKHNDLNELEQLLQSYPKSVPKLIA 250 N H + + K+ F+ N++ +L + + + + Sbjct: 121 SAHNSFHGRTLGSLTATGQPKYQKPFEPLVPGFEYFEFNNVEDLRRKMSEDVCA----VF 176 Query: 251 FESVYSMAGSVAD----IEKICDLADKYGALTFLDEVH-AVGLYGP----HGAGVAEHCD 301 E + +G V +E+ L D+Y AL DEV +G G GV Sbjct: 177 LEPIQGESGIVPATKEFLEEARKLCDEYDALLVFDEVQCGMGRTGKLFAYQKYGVVPDVL 236 Query: 302 FESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAP 361 + G V++ D T G G + F Sbjct: 237 TTAKGLGGGVPIGAVIVNERANVLEPGDHGTTFGGNPLACRAGVTVIKELTKEGFLE--- 293 Query: 362 GFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIVP 421 + L Q+ G+ + ++ Sbjct: 294 --------------------EVEEKGNYLMKKLQEMKEEYDVVADVRGMGL------MIG 327 Query: 422 VLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVD 481 + ++ + ++++ V V G +R P D+ + + Sbjct: 328 IQFREEVSNREVATKCF-ENKLLV-------VPAGNNTIRFLPPLTVEYGEIDLAVETLK 379 Query: 482 DV 483 V Sbjct: 380 KV 381 >5XT5-A nrPDB Length = 419 Score = 54.4 bits (129), Expect = 1e-07, Method: Composition-based stats. Identities = 70/427 (16%), Positives = 147/427 (34%), Gaps = 70/427 (16%) Query: 95 NINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPEVLDAMHKTIDKY----------G 144 NI + ++FP+ H+Q + YL + + A+ +T+DKY G Sbjct: 5 NITDIREQFPILHQQVNGHDLV------YLDSAATSQKPRAVIETLDKYYNQYNSNVHRG 58 Query: 145 CGAGGTRNIAGHNIPTLNLEAELATLHKKEGA--LVFSSCYVANDAVLSLLG-----QKM 197 GTR G+ ++ + ++F+ + +++L + Sbjct: 59 VHTLGTRATDGY----EGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALSYARANLKPG 114 Query: 198 KDLVIFSDELNHASMI---VGIKHANVKKHIFKHN-----DLNELEQLLQSYPKSVPKLI 249 ++VI E HA++I +K L ++ + + S K++ Sbjct: 115 DEVVITYMEH-HANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETV----TSNTKIV 169 Query: 250 AFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASG 309 A V ++ G+V I+++ +A GA+ +D + PH + Sbjct: 170 AVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQST----PH---MKIDVQDLDCDFFA 222 Query: 310 IATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAP-----GFI 364 +++ K G + + ++ FG ++ID+ + + Sbjct: 223 LSSHKMCGPTGVGVLYGKKALLENMEPAEFGG---------EMIDFVGLYESTWKELPWK 273 Query: 365 FTTTLPPSVMA-GATAAIRYQR--CHIDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIVP 421 F P A G AAI + ++ + K Y + F +L + P Sbjct: 274 FEAGTPIIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAG 333 Query: 422 VLIGN-ADLAKQASDILINKHQIYVQAINFPTVARG-----TERLRITPTPGHTNDLSDI 475 ++ N D+ +++ I V+A + T R + +T + D Sbjct: 334 LVTFNLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDK 393 Query: 476 LINAVDD 482 L+ A+ Sbjct: 394 LVEALQK 400 >5VMB-A nrPDB Length = 425 Score = 54.1 bits (128), Expect = 1e-07, Method: Composition-based stats. Identities = 76/387 (19%), Positives = 126/387 (32%), Gaps = 67/387 (17%) Query: 110 READKVTVWCSNDYLALSKHPEVLDA-MHKTIDKYGCGAGGTRNIAGH---NIPTLNLEA 165 R+ + + S +Y + P V++A K +KY G G R G ++ Sbjct: 32 RQEAHIELIASENYCS----PAVMEAQGSKLTNKYAEGYPGKRYYGGCEFVDVIEQMAID 87 Query: 166 ELATLHKKEGALVF-SSCYVANDAVLSLLGQKMKDLVIFSDELNHAS-MIVGIKHANV-- 221 L + A V + AN AV L + L H + G K + Sbjct: 88 RAKELFGADYANVQPHAGSQANSAVY--LALLNPGDTVLGMSLAHGGHLTHGAKVSFSGK 145 Query: 222 --KKHIFKHN------DLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADK 273 + N D E+E+L + P++I +S V D ++ D+ADK Sbjct: 146 TYNAVQYGLNAETGEIDYEEVERL---ALEHKPRMIVAG--FSAYSRVVDWQRFRDIADK 200 Query: 274 YGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITG 333 GA F+D H GL AGV + + + + + I Sbjct: 201 VGAYLFVDMAHVAGLV---AAGVYPNPVQIADVTTTTTHKTLRGPRSGLILAKANEEIEK 257 Query: 334 TLGKSF--GSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLR 391 L + G+ GG P + A A AI ++ D Sbjct: 258 KLQSAVFPGNQGG--------------------------PLMHAIAAKAICFKEAMSDDF 291 Query: 392 TSQQ----KHTMYVKKAFHELGIPV--IPNPSHIVPVLIGNADLAKQASDILINKHQIYV 445 + Q K+ + + F G V +H+ + + D+ + +D + I V Sbjct: 292 KAYQQQVVKNAQAMAEVFIARGYDVVSGGTDNHLFLLSLIKQDVTGKDADAWLGAAHITV 351 Query: 446 QAINFPTVARG---TERLRITPTPGHT 469 + P R T +RI T Sbjct: 352 NKNSVPNDPRSPFVTSGIRIGTPAVTT 378 >3VK2-A nrPDB Length = 398 Score = 54.1 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 35/144 (24%), Positives = 62/144 (43%), Gaps = 9/144 (6%) Query: 143 YGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVI 202 G +R LEA +A+L E L +S A + L L + ++++ Sbjct: 53 EQAGHFYSRISNPTLN---LLEARMASLEGGEAGLALASGMGAITSTLWTLLRPGDEVLL 109 Query: 203 FSDELNH--ASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGS 260 + H A + GI VK +H D+ +L+ L++ ++I FES + Sbjct: 110 GNTLYGHTFAFLHHGIGEFGVKL---RHVDMADLQA-LEAAMTPATRVIYFESPANPNMH 165 Query: 261 VADIEKICDLADKYGALTFLDEVH 284 +ADI + +A K+GA +D + Sbjct: 166 MADIAGVAKIARKHGATVVVDNTY 189 >4OBV-D nrPDB Length = 490 Score = 52.9 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 37/223 (16%), Positives = 76/223 (34%), Gaps = 35/223 (15%) Query: 101 KEFPLAHRQREADKVTVWCSND---YLALSKHPEVLDAMHKTIDK-----------YGCG 146 K+ + + R ++V N+ Y + HP + Y Sbjct: 61 KQIKIPEKGRPVNEVVSEMMNEVYRYRGDANHPRFFSFVPGPASSVSWLGDIMTSAYNIH 120 Query: 147 AGGTRNIAGHNIPTLNLEAELAT---LHKKEGALVFSSCYVANDAVLSLLGQKMKDLV-- 201 AGG++ N + LA + G + S +AN L+ + Sbjct: 121 AGGSKLAPMVNCIEQEVLKWLAKQVGFTENPGGVFVSGGSMANITALTAARDNKLTDINL 180 Query: 202 -----IFSDELNHASMIVGIKH---ANVKKHIFKHN-----DLNELEQLLQSYPKSV--P 246 SD+ H+S+ G++ + + N D +LE+ +++ KS P Sbjct: 181 HLGTAYISDQ-THSSVAKGLRIIGITDSRIRRIPTNSHFQMDTTKLEEAIETDKKSGYIP 239 Query: 247 KLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLY 289 ++ + + GS+ + +I L K+ +D + + Sbjct: 240 FVVIGTAGTTNTGSIDPLTEISALCKKHDMWFHIDGAYGASVL 282 >4JF0-A nrPDB Length = 422 Score = 52.5 bits (124), Expect = 4e-07, Method: Composition-based stats. Identities = 42/250 (16%), Positives = 77/250 (30%), Gaps = 33/250 (13%) Query: 129 HPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDA 188 HP A+ + + G T + N P L L +L E L +S AN+ Sbjct: 75 HP----ALVEALKSQGETLWHTSRVF-TNEPALRLGRKLIDATFAERVLFMNSGTEANET 129 Query: 189 VLSLL--------GQKMKDLVIFSDELNHASMI-----------VGIKHANVKKHIFKHN 229 L ++ F + + S+ G N Sbjct: 130 AFKLARHYACVRHSPFKTKIIAFHNAFHGRSLFTVSVGGQPKYSDGFGPKPADIIHVPFN 189 Query: 230 DLNELEQLLQSYPKSVPKLIAFESVYSMAGSVAD----IEKICDLADKYGALTFLDEVH- 284 DL+ ++ ++ + + + E + G A ++ + DL D++ AL DEV Sbjct: 190 DLHAVKAVMDDHTCA----VVVEPIQGEGGVQAATPEFLKGLRDLCDEHQALLVFDEVQC 245 Query: 285 AVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGG 344 +G G A + + ++ T G+ G ++G Sbjct: 246 GMGRTGDLFAYMHYGVTPDILTSAKALGGGFPVSAMLTTQEIASAFHVGSHGSTYGGNPL 305 Query: 345 YVAASRKLID 354 A + D Sbjct: 306 ACAVAGATFD 315 >2YKV-A nrPDB Length = 465 Score = 52.1 bits (123), Expect = 6e-07, Method: Composition-based stats. Identities = 32/166 (19%), Positives = 56/166 (33%), Gaps = 17/166 (10%) Query: 128 KHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVAND 187 HP + A+ + + A G L EA + +S AN Sbjct: 117 SHPVIRAAVERAL------AVGLNLSTQTENEALFAEAVCDRFPSIDLVRFTNSGTEANL 170 Query: 188 -AVLSLLGQKMKDLVIFSDELNHASMIV---GIKHANVKKHIFK--HNDLNELEQLLQSY 241 A+ + + V+ D H ++ G N H+ +ND+ LL+ + Sbjct: 171 MALATATAITGRKTVLAFDGGYHGGLLNFASGHAPTNAPYHVVLGVYNDVEGTADLLKRH 230 Query: 242 PKSVPKLIAFESVYSMAGSVAD----IEKICDLADKYGALTFLDEV 283 ++ E + G V ++ + A + GAL DEV Sbjct: 231 GHDCAAILV-EPMLGAGGCVPAERAFLDLLRAEASRCGALLIFDEV 275 >4ZM4-A nrPDB Length = 447 Score = 52.1 bits (123), Expect = 6e-07, Method: Composition-based stats. Identities = 56/366 (15%), Positives = 98/366 (26%), Gaps = 92/366 (25%) Query: 170 LHKKEGALVFSSCYVANDAVLSLL-GQKMKDLVIFSDELNH------------ASMIVGI 216 + E +S A + L L + LV+ + H A + G Sbjct: 111 VPGVEQVRFANSGTEAVASALRLARATTGRTLVVTFEGHYHGWSETVLRAGKTALHMEGT 170 Query: 217 KHAN-------------VKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVAD 263 + + ND + L +L + +I E V + AG + Sbjct: 171 RPTDVVPGALGMIPEALAHTVQLGWNDPDALRELFARDGDRIAAVIV-EPVLANAGVIPP 229 Query: 264 ----IEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKG 319 ++ + +L + GA+ DEV G G G E E Sbjct: 230 APGFLQLLRELTGRSGAMLVFDEV-ITGFRVARG-GAQERYGVEPDLTVLSRVMGGGFPV 287 Query: 320 GAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATA 379 A + L + G A + + + A Sbjct: 288 AAFGGRRHAMRM---LASNEAHHAGVYAGNH---------------------AALRAVVA 323 Query: 380 AIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPSHI--------VPVLIGNADLAK 431 + R DL + Y++ E+ P HI V +L G+A+ + Sbjct: 324 MLGKIRSLPDLYERLEDTGQYMEDTVREV-FATEKRPVHINRVGTLMSVALLKGSAEPSA 382 Query: 432 QASDI-----------------LINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSD 474 + D+ L K +Y + HT D+ D Sbjct: 383 EPRDLRQLAALVDFPRHRRLQTLAQKEGVYFHP---------NALEPWFLSTAHTRDVID 433 Query: 475 ILINAV 480 + A+ Sbjct: 434 KVAGAL 439 >2CY8-A nrPDB Length = 453 Score = 51.7 bits (122), Expect = 9e-07, Method: Composition-based stats. Identities = 35/187 (18%), Positives = 59/187 (31%), Gaps = 30/187 (16%) Query: 129 HPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDA 188 HP V A+ + + + G + A H + E +A S Sbjct: 75 HPRVNAAIAEAL------SHGVQYAASHPLEVRWAERIVAAFPSIRKLRFTGSGTETTLL 128 Query: 189 VLS---LLGQKMKDLVIFSDELN--------HASMIVGIKH------ANVKKHIFKHNDL 231 L + L + S G + + +D+ Sbjct: 129 ALRVARAFTGRRMILRFEGHYHGWHDFSASGYNSHFDGQPAPGVLPETTANTLLIRPDDI 188 Query: 232 NELEQLLQSYPKSVPKLIAFESVYSMAGSVAD-----IEKICDLADKYGALTFLDEVHAV 286 + ++ ++ + IA E V S G V + + +LA +YGAL LDEV + Sbjct: 189 EGMREVFANHGSDIAAFIA-EPVGSHFG-VTPVSDSFLREGAELARQYGALFILDEVISG 246 Query: 287 GLYGPHG 293 G HG Sbjct: 247 FRVGNHG 253 >2EO5-A nrPDB Length = 419 Score = 51.4 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 75/383 (19%), Positives = 118/383 (30%), Gaps = 65/383 (16%) Query: 110 READKVTVWCSN---DYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAE 166 + +K + S + L HPEV+ + + K A +NIP L L + Sbjct: 39 VDGNKYLDFTSGIGVNNLGWPSHPEVIKIGIEQMQKLAHAAANDF----YNIPQLELAKK 94 Query: 167 LATLH--KKEGALVFS-SCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKK 223 L T + + FS S A +A + ++ + +I H I K Sbjct: 95 LVTYSPGNFQKKVFFSNSGTEAIEASIKVVKNTGRKYIIAFLGGFHGRTFGSISLTASKA 154 Query: 224 H---------------IFKH--------NDLNELEQLLQSY--------------PKSVP 246 + + N +L+ P+ V Sbjct: 155 VQRSIVGPFMPGVIHVPYPNPYRNPWHINGYENPSELVNRVIEFIEDYIFVNLVPPEEVA 214 Query: 247 KLIAFESVYSMAGSVAD----IEKICDLADKYGALTFLDEVH-AVGLYGPHGAGVAEHCD 301 I FE + G V ++ LA KYG L DEV +G G A + Sbjct: 215 G-IFFEPIQGEGGYVIPPKNFFAELQKLAKKYGILLVDDEVQMGLGRTGKLFA-IENFNT 272 Query: 302 FESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAP 361 A GA +D G +FG A K+ID + P Sbjct: 273 VPDVITLAKALGGGIMPIGATIFRKDLDFKPGMHSNTFGGNALACAIGSKVIDIVKDLLP 332 Query: 362 GF-----IFTTTLPPSV--MAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIP 414 IF L + G A + +R + K+ L +P Sbjct: 333 HVNEIGKIFAEELQGLADDVRGIGLAWGLEYNEKKVRDRIIGES--FKRGL--LLLPAGR 388 Query: 415 NPSHIVPVLIGNADLAKQASDIL 437 + ++P L+ + + AKQ DIL Sbjct: 389 SAIRVIPPLVISEEEAKQGLDIL 411 >1WKH-A nrPDB Length = 395 Score = 51.4 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 46/271 (16%), Positives = 80/271 (29%), Gaps = 62/271 (22%) Query: 227 KHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVAD-----IEKICDLADKYGALTFLD 281 +ND+ L++ + + + E V G V + ++ + GAL LD Sbjct: 171 PYNDVEALKRAVDEETAA----VILEPVQG-EGGVRPATPEFLRAAREITQEKGALLILD 225 Query: 282 EVH-AVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFG 340 E+ +G G EH TL K+ G Sbjct: 226 EIQTGMGRTGK--RFAFEHFGIVPDIL--------------------------TLAKALG 257 Query: 341 SVG--GYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHT 398 G ++ G F P MA AAIRY RT + Sbjct: 258 GGVPLGVAVMREEVARSMPKGGHGTTFGGN--PLAMAAGVAAIRYLE-----RTRLWERA 310 Query: 399 M----YVKKAFHELGIPVIPNPSHIVPVLIGNA--DLAKQASDILINKHQIYVQAINFPT 452 + + + P I + +++G + A L +H++ Sbjct: 311 AELGPWFMEKLRAIPSPKIREVRGM-GLMVGLELKEKAAPYIARLEKEHRVL-------A 362 Query: 453 VARGTERLRITPTPGHTNDLSDILINAVDDV 483 + G +R P + + ++ AV V Sbjct: 363 LQAGPTVIRFLPPLVIEKEDLERVVEAVRAV 393 >1M32-A nrPDB Length = 366 Score = 51.0 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 48/317 (15%), Positives = 93/317 (29%), Gaps = 27/317 (8%) Query: 119 CSNDYLALSKHPEVL-DAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGAL 177 S +YL L+ P + + + C NI L A L Sbjct: 1 TSRNYLLLTPGPLTTSRTVKEAMLFDSCTWDDDYNIGVVEQIRQQLTALATASEGYTSVL 60 Query: 178 VFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIF-----KHNDLN 232 + S A +AVL ++I S+ A M+ + H + D+ Sbjct: 61 LQGSGSYAVEAVLGSALGPQDKVLIVSNGAYGARMVEMAGLMGIAHHAYDCGEVARPDVQ 120 Query: 233 ELEQLLQSYPK-SVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGP 291 ++ +L + P S ++ E+ G + I+++ LA +YG +D + + G Sbjct: 121 AIDAILNADPTISHIAMVHSET---TTGMLNPIDEVGALAHRYGKTYIVDAMSSFG---- 173 Query: 292 HGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRK 351 A+ + + + K G + S Sbjct: 174 ---------GIPMDIAALHIDYLISSANKCIQGVPGFAFVIAREQKLAACKGHSRSLSLD 224 Query: 352 LI---DWFRSFAPGFIFTT-TLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHE 407 L + FT+ T A A + + Q++ + Sbjct: 225 LYAQWRCMEDNHGKWRFTSPTHTVLAFAQALKELAKEGGVAARHQRYQQNQRSLVAGMRA 284 Query: 408 LGIPVIPNPSHIVPVLI 424 LG + + P++ Sbjct: 285 LGFNTLLDDELHSPIIT 301 >3CQ5-A nrPDB Length = 369 Score = 51.0 bits (120), Expect = 2e-06, Method: Composition-based stats. Identities = 47/295 (15%), Positives = 96/295 (32%), Gaps = 44/295 (14%) Query: 158 IPTLNLEAELATLHKKEG--ALVFSSCYVANDA------VLSLLGQKMKDLVIFSDELN- 208 + L ELA K+ A+ + + AN + +L G + + F + Sbjct: 69 RDAVELRDELAAYITKQTGVAVTRDNLWAANGSNEILQQLLQAFGGPGRTALGFQPSYSM 128 Query: 209 HASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKIC 268 H + G + ++ ++ L+ P ++ + + G V ++ + Sbjct: 129 HPILAKGTHTEFIAVSRGADFRID-MDVALEEIRAKQPDIVFVTTPNNPTGDVTSLDDVE 187 Query: 269 DLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRV 328 + + + +DE +A + + +K K V+ R Sbjct: 188 RIINVAPGIVIVDEAYA-------------------EFSPSPSATTLLEKYPTKLVVSR- 227 Query: 329 DMITGTLGKSF---GSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQR 385 T+ K+F G GY A+ ID + + A A A+R+ Sbjct: 228 -----TMSKAFDFAGGRLGYFVANPAFIDAVMLVRLPYHLSA----LSQAAAIVALRHSA 278 Query: 386 CHIDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIVPVLIGNADLAKQASDILINK 440 + + V ELG V+P+ S+ V G+ A +++ Sbjct: 279 DTLGTVEKLSVERVRVAARLEELGYAVVPSESNF--VFFGDFSDQHAAWQAFLDR 331 >2HUU-A nrPDB Length = 393 Score = 50.2 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 53/360 (14%), Positives = 112/360 (31%), Gaps = 31/360 (8%) Query: 148 GGTRNIAGHNI-PTLNLEAELAT----LHKKEGALVFSSCYVANDAVLSLLGQK-MKDLV 201 +R I GH TL + ++ L + F + + + L V Sbjct: 37 AMSRPILGHLHPETLKIMDDIKEGVRYLFQTNNIATFCLSASGHGGMEATLCNLLEDGDV 96 Query: 202 IFSDELNH-----ASMIVGIKH-ANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVY 255 I H A M ++ A+V+ K L+++ + P ++ Sbjct: 97 ILIGHTGHWGDRSADM--ATRYGADVRVVKSKVGQSLSLDEIRDALLIHKPSVLFLTQGD 154 Query: 256 SMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKT 315 S G + +E + L ++ L +D V ++G G D A + K Sbjct: 155 SSTGVLQGLEGVGALCHQHNCLLIVDTVASLG-------GAPMFMDRWEIDAMYTGSQKV 207 Query: 316 NDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMA 375 T + + V Y + D++ F I+ T+ +++ Sbjct: 208 LGAPPGITPVSFSHRAVERYKRRNTKVKVYYWDMSLVGDYWGCFGRPRIYHHTISSTLLY 267 Query: 376 GATAAIRYQ--RCHIDLRTSQQKHTMYVKKAFHELGIPVIPNP----SHIVPVLIGNADL 429 G AI L + + + + G + +P S + + + Sbjct: 268 GLREAIAMACEEGLPALIARHEDCAKRLYRGLQDAGFELYADPKDRLSTVTTIKVPQGVD 327 Query: 430 AKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGH-TNDLSDILINAVDDVFNELQ 488 +A+ + + + + PT G RI + T + D ++ + ++ Sbjct: 328 WLKAAQYAMKTYLVEISGGLGPT--AGQ-VFRIGLMGQNATTERVDRVLQVFQEAVAAVK 384 >4BQ0-A nrPDB Length = 448 Score = 49.8 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 58/373 (15%), Positives = 117/373 (31%), Gaps = 46/373 (12%) Query: 133 LDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSL 192 + + + G A +I L +K + + Y + + Sbjct: 103 IAGLLPGELNHVFFTGSGSECADTSIKMARAYWRLKGQPQKTKLIGRARGYHGVNVAGTS 162 Query: 193 LGQKMKDLVIFS-----DELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPK 247 LG + +F D L H ++ G+ NEL +L++ + S Sbjct: 163 LGGIGGNRKMFGQLMDVDHLPH-TLQPGMAFTRGMAQTGGVELANELLKLIELHDASNIA 221 Query: 248 LIAFESVYSMAGSVAD----IEKICDLADKYGALTFLDEV-HAVGLYGPHGAGVAEHCDF 302 + E + AG + ++++ ++ D++ L DEV A G G + Sbjct: 222 AVIVEPMSGSAGVLVPPVGYLQRLREICDQHNILLIFDEVITAFGRLGTYSGAEYFGVTP 281 Query: 303 ESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPG 362 + + T G + D ++ L + F+ G Sbjct: 282 DLMNVAKQVTNGAVPMGAVIASSEIYDTFM----------------NQALPEHAVEFSHG 325 Query: 363 FIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFH----ELGIPVIPNPSH 418 + ++ P A AA+ +L + + +K H + I N Sbjct: 326 YTYSAH--PVACAAGLAALDIL-ARDNLVQQSAELAPHFEKGLHGLQGAKNVIDIRNCGL 382 Query: 419 IVPVLI----GNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSD 474 + I G+ + + + + + YV F G + L+ PT + D Sbjct: 383 AGAIQIAPRDGDPTVRPFEAGMKLWQQGFYV---RF-----GGDTLQFGPTFNARPEELD 434 Query: 475 ILINAVDDVFNEL 487 L +AV + N + Sbjct: 435 RLFDAVGEALNGI 447 >4W91-A nrPDB Length = 422 Score = 49.4 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 74/421 (17%), Positives = 134/421 (31%), Gaps = 49/421 (11%) Query: 94 NNINRLAKEFPLAHRQREADKVTVWCSNDYL---ALSKHPE-VLDAM-HKTIDKYGCGAG 148 ++ + ++FP+ RQ + YL A ++ P+ V+DA+ H ++Y Sbjct: 19 YDVEAIRRDFPILSRQVHGKTLV------YLDNGASAQKPQSVIDAVTHAYANEYANVHR 72 Query: 149 GTRNI-AGHNIPTLNLEAELATLHKKEGA--LVFSSCYVANDAVLSL-----LGQKMKDL 200 G + + +VF+ A +A+ ++ + + Sbjct: 73 GLHFLSNAATDAYEKSRETVRRFLNAGSVDEIVFTK--NATEAINTVAYGYGMPFIGEGD 130 Query: 201 VIFSDELNHASMIVG---IKHANVKKHIFK---HNDLNELEQLLQSYPKSVPKLIAFESV 254 I + H S IV I+ K +F N + +E+ + KL+A + Sbjct: 131 EILLSIMEHHSNIVPWHFIRERQGAKLVFTPVDDNGVFHIEE-FEKRLSERTKLVAITHM 189 Query: 255 YSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPK 314 + G+V I+KI +LA G +D G GA + + T Sbjct: 190 SNTLGTVVPIKKIVELAHARGIPVLVD--------GSQGAVHLPVDVQDLGCDWYVFTGH 241 Query: 315 TNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVM 374 V+ + L K GG + P F PP V Sbjct: 242 KVYGPSGIGVLYGRAQM---LEKMRPFQGGGEMIEEVTEENVTYNHPPHRFEAGTPPIVQ 298 Query: 375 A-GATAAIRYQRCHIDL-RTSQQKHTM-YVKKAFHELGIPVIPNPSHIVPVLIGNADLAK 431 A G AA+ Y + + Y + + I + +I A Sbjct: 299 AIGLGAALEYMEKIGRHAILAHEADLRDYAHERLGRINSLRIFGNAPDKGAIISFALEGI 358 Query: 432 QASD--ILINKHQIYVQAINFPTVA-----RGTERLRITPTPGHTNDLSDILINAVDDVF 484 A D ++I++ + V+A T R + +T D L A++ Sbjct: 359 HAHDVSMVIDRAGVAVRAGTHCAQPLLKRFGVTSTCRASFALYNTRAEVDALAEALEKAR 418 Query: 485 N 485 Sbjct: 419 K 419 >5VIU-A nrPDB Length = 419 Score = 49.0 bits (115), Expect = 5e-06, Method: Composition-based stats. Identities = 67/438 (15%), Positives = 135/438 (30%), Gaps = 78/438 (17%) Query: 80 ELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSK---HPEVLDAM 136 EL++K +Y + + E E K + S Y A+++ HP++++A+ Sbjct: 20 ELEEKHGAHNY-HPLPVVLDRGEGVFV-WDVEGKKYYDFLS-AYSAVNQGHSHPKIVEAL 76 Query: 137 HKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLL--- 193 + K A +R +N E ++ +L + L +S A + + L Sbjct: 77 VEQASKL---ALTSRAF--YNSKLGEYEQKITSLLGFDKVLPMNSGAEAVETAVKLARKW 131 Query: 194 -----GQKMKDLVIFSDELN-HASMIVGIKHANVK------------KHIFKHNDLNELE 235 G I E N H + +N +ND+ LE Sbjct: 132 SYEVKGIAENAAKIIVCENNFHGRTTTIVSFSNDPDANQNYGPFTPGFIRIPYNDIAALE 191 Query: 236 QLLQSYPKSVPKLIAFESVYSMAGSVAD----IEKICDLADKYGALTFLDEVHAVGLYGP 291 ++L ++ + E + AG +++ +L K+ L DEV Sbjct: 192 EVLSKEAGNIAAFLV-EPIQGEAGVYVPNEGFLKQSSELCKKHNVLFIADEVQT------ 244 Query: 292 HGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRK 351 G+A + + M V V A+ Sbjct: 245 ---GIARTGKLIACHHEDVQPDILILGKALSGGMYPV---------------SAVLANNN 286 Query: 352 LIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHEL--- 408 ++D + G F P A A AA+ + L +K + +L Sbjct: 287 IMDVIKPGQHGSTFGGN--PLACAVAMAALDVVQDE-KLSERAEKLGNLFRSEIEKLIEK 343 Query: 409 --GIPVIPNPSHIVPVLIGNADLAKQASDIL--INKHQIYVQAINFPTVARGTERLRITP 464 I + + +LI + + A ++ + ++ + +R+ P Sbjct: 344 TDLITKVRGKGLLNAILINDTPDSSTAWNLCLALKENGLL-------AKPTHGNIIRLAP 396 Query: 465 TPGHTNDLSDILINAVDD 482 T + + ++ Sbjct: 397 PLVITEEQLLDCVKIIEK 414 >4WXB-A nrPDB Length = 428 Score = 49.0 bits (115), Expect = 5e-06, Method: Composition-based stats. Identities = 42/215 (19%), Positives = 77/215 (35%), Gaps = 23/215 (10%) Query: 89 SYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPEVLDAMHKTI--DKYGCG 146 + + A +R+ + + + S + ++ + + A T+ +KY G Sbjct: 16 DKEDYKAFDPELWNAIDAEAERQQNNIELIASENVVSKA-----VMAAQGTLLTNKYAEG 70 Query: 147 AGGTRNIAGHNI----PTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLV- 201 G R G + TL +E K + S AN AV L Q ++ Sbjct: 71 YPGKRYYGGTAVIDVVETLAIERAKKLFGAKFANVQPHSGSQANAAVYMSLIQPGDTVMG 130 Query: 202 IFSDELNHASMIVGIKHANV-KKHIFKHNDLN------ELEQLLQSYPKSVPKLIAFESV 254 + H + G + K + F +++ + + +L + PKLI + Sbjct: 131 MDLSAGGH--LTHGAPVSFSGKTYNFVSYNVDKESELLDYDAILAQAKEVRPKLIVAGA- 187 Query: 255 YSMAGSVADIEKICDLADKYGALTFLDEVHAVGLY 289 S + D K ++AD GA +D H GL Sbjct: 188 -SAYSRIIDFAKFREIADAVGAYLMVDMAHIAGLV 221 >3N0L-A nrPDB Length = 417 Score = 48.7 bits (114), Expect = 6e-06, Method: Composition-based stats. Identities = 73/389 (18%), Positives = 136/389 (34%), Gaps = 55/389 (14%) Query: 130 PEVLDAMHKTI-DKYGCGAGGTRNIAGHN----IPTLNLEAELATLHKKEGALVFSSCYV 184 PEV++ M + +KY G G R G I TL +E + K + +S Sbjct: 39 PEVMEVMGSILTNKYAEGYPGKRYYGGCEFVDEIETLAIERCKKLFNCKFANVQPNSGSQ 98 Query: 185 ANDAVLSLLGQKMKDLVIFSDELNHAS-MIVGIKHANVKKHI---FKHNDLN---ELEQL 237 AN V + L I +L+H + G K ++ K F +L+ + E++ Sbjct: 99 ANQGVYAAL--INPGDKILGMDLSHGGHLTHGAKVSSSGKMYESCFYGVELDGRIDYEKV 156 Query: 238 LQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVA 297 + K PKLI + S V D K ++AD+ GA F D H GL Sbjct: 157 REIAKKEKPKLIVCGA--SAYARVIDFAKFREIADEIGAYLFADIAHIAGLV-------- 206 Query: 298 EHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSF-GSVGGYVAAS-RKLIDW 355 G + +++ T K+ G GG + + +L Sbjct: 207 -------------------VAGEHPSPFPYAHVVSSTTHKTLRGPRGGIIMTNDEELAKK 247 Query: 356 FRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQK-HTMYVKKAFHELGIPVIP 414 S I L + A A + Q + + + + ++ Sbjct: 248 INSAIFPGIQGGPLMHVIAAKAVGFKFNLSDEWKVYAKQVRTNAQVLANVLMDRKFKLVS 307 Query: 415 N--PSHIVPVLIGNADLAKQASDILINKHQI-----YVQA-INFPTVARGTERLRITPTP 466 + +H+V + + + + + +D+ + I V I P + G T Sbjct: 308 DGTDNHLVLMSFLDREFSGKDADLALGNAGITANKNTVPGEIRSPFITSGLRLGTPALTA 367 Query: 467 -GHTNDLSDILINAVDDVFNELQLPRVRD 494 G +I+ N + D+ +++ ++++ Sbjct: 368 RGFKEKEMEIVSNYIADILDDVNNEKLQE 396 >5X3F-A nrPDB Length = 501 Score = 48.7 bits (114), Expect = 6e-06, Method: Composition-based stats. Identities = 74/492 (15%), Positives = 151/492 (30%), Gaps = 97/492 (19%) Query: 52 THAAAAAAAAANHST---QESGFDYE---GLIDSELQ--KKRLDKSYRYFNNINRLAKEF 103 +H +A+A A + H+ ++ D+E L ++ K+ ++ + + ++ Sbjct: 2 SHMSASALACSAHALNLIEKRTLDHEEMKALNREVIEYFKEHVNPGFLEYRKSVTAGGDY 61 Query: 104 PLAHRQREADKVTVWCSN----DYLAL-------SKHPEVLDAMHKTIDKYGCGAGGTRN 152 Q + V D L ++P V+ A+ + K Sbjct: 62 GAVEWQAGSLNTLVDTQGQEFIDCLGGFGIFNVGHRNPVVVSAVQNQLAK--QPLHSQEL 119 Query: 153 IAGHNIPTLNLEAELATL-HKKEGALVF-SSCYVANDAVLSLL----GQKMKDLVIFSDE 206 + L LA L K F +S + +A L L + K I + Sbjct: 120 LDP---LRAMLAKTLAALTPGKLKYSFFCNSGTESVEAALKLAKAYQSPRGKFTFIATSG 176 Query: 207 LNHASMIVGIKHANVKKHI---------FKH---NDLNELEQLLQSYPKSVPKL--IAFE 252 H + + F+H ++ + L K+ + + E Sbjct: 177 AFHGKSLGALSATAKSTFRKPFMPLLPGFRHVPFGNIEAMRTALNECKKTGDDVAAVILE 236 Query: 253 SVYSMAGSVAD----IEKICDLADKYGALTFLDEVH-AVGLYGPHGAGVAEHCDFESHRA 307 + G + + + L D++GAL LDEV +G G C+ E+ + Sbjct: 237 PIQGEGGVILPPPGYLTAVRKLCDEFGALMILDEVQTGMGRTGK-----MFACEHENVQP 291 Query: 308 SGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVG---GYVAASRKLIDWFRSFAPGFI 364 + L K+ G G A+ ++ F F+ Sbjct: 292 DILC-----------------------LAKALGGGVMPIGATIATEEVFSVL--FDNPFL 326 Query: 365 FTTTLP--PSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPV------IPNP 416 TTT P A A A I +L ++ + F +L Sbjct: 327 HTTTFGGNPLACAAALATINVLL-EQNLPAQAEQKGDMLLDGFRQLAREYPDLVQEARGK 385 Query: 417 SHIVPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDIL 476 ++ + + ++ + + + + +N +RI P T + +++ Sbjct: 386 GMLMAIEFVDNEIGYNFASEMFRQRVLVAGTLNNAKT------IRIEPPLTLTIEQCELV 439 Query: 477 INAVDDVFNELQ 488 I A ++ Sbjct: 440 IKAARKALAAMR 451 >6GIO-D nrPDB Length = 439 Score = 48.7 bits (114), Expect = 6e-06, Method: Composition-based stats. Identities = 58/321 (18%), Positives = 93/321 (28%), Gaps = 67/321 (20%) Query: 129 HPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKK-EGALVFS-SCYVAN 186 HP +++A+ K++ AG + + + E L E + F S AN Sbjct: 60 HPAIVEAVEKSVRDM---AGASLLLYPNEAAVSLAEDLLRITPGNGERRVWFGHSGSDAN 116 Query: 187 DA---VLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDL------------ 231 D VL+ ++ + + + + +GI H + Sbjct: 117 DCAVRVLTAATKRSRIISFIGSYHGNLTGSMGISGHTAMTHTLPRPGVLLLPYPDPFRPR 176 Query: 232 ---NELEQLLQ-----SYPKSVPKLIAFESVYSMAGSVAD----IEKICDLADKYGALTF 279 + +LL S P + E + S G V +E + D K+G L Sbjct: 177 FSAEAVLELLDYHFATSCPPEQVAAVFIEPILSDGGLVVPPPAFLEALQDRCRKHGILVV 236 Query: 280 LDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSF 339 +DEV VGL G HC + GG + G Sbjct: 237 VDEV-KVGL----GRTGLMHCFQHEGLEPDMVVFGKGLGGGLPLSA-----VVGP----- 281 Query: 340 GSVGGYVAASRKLIDWFRSFAPGFIF-TTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHT 398 W AP F+ TT P A A + R + + Sbjct: 282 --------------QWVMDHAPAFVLQTTAGNPVATAAGRAVLNTIE-----RQGLAQRS 322 Query: 399 MYVKKAFHELGIPVIPNPSHI 419 V F + + S I Sbjct: 323 ERVGGIFADRLRRLSDKHSII 343 >3H7F-A nrPDB Length = 447 Score = 47.9 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 71/374 (18%), Positives = 116/374 (31%), Gaps = 62/374 (16%) Query: 142 KYGCGAGGTRNIAGHNIPTLNLEAELA-----TLHKKEGALVF-SSCYVANDAVLSLLGQ 195 KY G G R G +++ LA L E A V S AN AVL L Sbjct: 72 KYAEGLPGRRYYGGC--EHVDVVENLARDRAKALFGAEFANVQPHSGAQANAAVLHALMS 129 Query: 196 KMKDLVIFSDELNHASMIVGIKHANVKKH-------IFKHNDLNELEQLLQSYPKSVPKL 248 + L + D N + G++ K + L +++ + + + PK+ Sbjct: 130 PGERL-LGLDLANGGHLTHGMRLNFSGKLYENGFYGVDPATHLIDMDAVRATALEFRPKV 188 Query: 249 IAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRAS 308 I +S V D +AD+ GA +D H GL AG+ + Sbjct: 189 IIAG--WSAYPRVLDFAAFRSIADEVGAKLLVDMAHFAGLV---AAGLHPSPVPHA---- 239 Query: 309 GIATPKTNDKGGAKTVMDRVDMITGTLGKSF-GSVGGYVAASRKLIDWFRSFAPGFIFTT 367 D+++ T+ K+ G G + ++ S Sbjct: 240 --------------------DVVSTTVHKTLGGGRSGLIVGKQQYAKAINSAVFPG--QQ 277 Query: 368 TLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIP----------VIPNPS 417 P + A + Q++ + L P Sbjct: 278 GGPLMHVIAGKAVALKIAATPEFADRQRRTLSGARIIADRLMAPDVAKAGVSVVSGGTDV 337 Query: 418 HIVPVLIGNADLAKQASDILINKHQIYVQ---AINFPTVARGTERLRITPTPGHTNDLSD 474 H+V V + ++ L QA++ L+++ I V N P T LRI T D Sbjct: 338 HLVLVDLRDSPLDGQAAEDLLHEVGITVNRNAVPNDPRPPMVTSGLRIGTPALATRGFGD 397 Query: 475 -ILINAVDDVFNEL 487 D + L Sbjct: 398 TEFTEVADIIATAL 411 >1Z7D-A nrPDB Length = 433 Score = 47.5 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 38/189 (20%), Positives = 66/189 (34%), Gaps = 34/189 (17%) Query: 129 HPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDA 188 HP +L+AM +R ++P E L L + L+ ++ AN+ Sbjct: 83 HPNILNAMINQAKNL---TICSRAF--FSVPLGICERYLTNLLGYDKVLMMNTGAEANET 137 Query: 189 VLSLLGQKMKDL--------VIFSDELNHASMIVGI------KHANVKKHIF-------K 227 L + ++ I + N + +G K F Sbjct: 138 AYKLCRKWGYEVKKIPENMAKIVVCKNNFSGRTLGCISASTTKKCTSNFGPFAPQFSKVP 197 Query: 228 HNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVAD----IEKICDLADKYGALTFLDEV 283 ++DL LE+ L+ +V I E + AG + ++ + D+ KY L DEV Sbjct: 198 YDDLEALEEELK--DPNVCAFIV-EPIQGEAGVIVPSDNYLQGVYDICKKYNVLFVADEV 254 Query: 284 H-AVGLYGP 291 +G G Sbjct: 255 QTGLGRTGK 263 >6MRE-A nrPDB Length = 420 Score = 46.7 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 39/217 (17%), Positives = 81/217 (37%), Gaps = 32/217 (14%) Query: 86 LDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHP-EVLDAMHKTIDKYG 144 +DK F ++R PLA+ A ++ P +V+DA + ++G Sbjct: 19 VDKVRADFPVLSREVNGLPLAYLDSAAS-------------AQKPSQVIDAEAE-FYRHG 64 Query: 145 CGA--GGTRNIAGHNIPTLN-LEAELATLHKKEGA--LVFSSCYVANDAVLSLLGQ---- 195 A G ++ + + + A LVF + +++ Sbjct: 65 YAAVHRGIHTLSAQATEKMENVRKRASLFINARSAEELVFVAGTTEGINLVANSWGNSNV 124 Query: 196 KMKDLVIFSDELNHASMIVGIKHA---NVKKHIFKHNDLNELEQLLQSYPK---SVPKLI 249 + D +I S +HA+++ + + N L+ L++ P +L+ Sbjct: 125 RAGDNIIISQMEHHANIVPWQMLCARVGAELRVIPLNPDGTLQ--LETLPTLFDEKTRLL 182 Query: 250 AFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAV 286 A V ++ G+ + ++ LA ++GA +D AV Sbjct: 183 AITHVSNVLGTENPLAEMITLAHQHGAKVLVDGAQAV 219 >2DR1-A nrPDB Length = 386 Score = 46.3 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 35/219 (15%), Positives = 72/219 (32%), Gaps = 61/219 (27%) Query: 231 LNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYG 290 +L+ L+ P I + + G + + ++ +A ++ L F+D V A+G Sbjct: 134 PEDLDDALRKNPDVEAVTITYNE--TSTGVLNPLPELAKVAKEHDKLVFVDAVSAMG--- 188 Query: 291 PHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDR--VDMITGTLGKSFGS-----VG 343 GA D+ +D++ + K+FG +G Sbjct: 189 -----------------------------GADIKFDKWGLDVVFSSSQKAFGVPPGLAIG 219 Query: 344 GYVAASRKLIDWFRSFAPGFIF--------------TTTLPPS-VMAGATAAIRYQRCHI 388 + ++ + G+ F T + PP + G A+R Sbjct: 220 AFSERFLEIAEKMPE--RGWYFDIPLYVKYLKEKESTPSTPPMPQVFGINVALRIIEKMG 277 Query: 389 DLRTSQ---QKHTMYVKKAFHELGIPVIPNPSHIVPVLI 424 +K V++ E+G+ ++ P H P + Sbjct: 278 GKEKWLEMYEKRAKMVREGVREIGLDILAEPGHESPTIT 316 >3NTJ-A nrPDB Length = 422 Score = 46.0 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 39/189 (20%), Positives = 61/189 (32%), Gaps = 34/189 (17%) Query: 129 HPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDA 188 HP++L+AM K +R + E L L + L+ ++ A++ Sbjct: 64 HPDILNAMINQAKKL---TICSRAF--FSDSLGVCERYLTNLFGYDKVLMMNTGAEASET 118 Query: 189 VLSLLGQ--------KMKDLVIFSDELNHASMIVGIKHANVKK-------------HIFK 227 L + I N + +G A+ K Sbjct: 119 AYKLCRKWGYEVKKIPENSAKIIVCNNNFSGRTLGCVSASTDKKCKNNFGPFVPNFLKVP 178 Query: 228 HNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVAD----IEKICDLADKYGALTFLDEV 283 ++DL LE+ LQ +V I E V AG + + L KY L DEV Sbjct: 179 YDDLEALEKELQ--DPNVCAFIV-EPVQGEAGVIVPSDSYFPGVASLCKKYNVLFVADEV 235 Query: 284 H-AVGLYGP 291 +G G Sbjct: 236 QTGLGRTGK 244 >3ECD-A nrPDB Length = 425 Score = 45.6 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 64/365 (17%), Positives = 115/365 (31%), Gaps = 64/365 (17%) Query: 132 VLDAMHKTI-DKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFS---------S 181 VLDA + +KY G G R G E+ L + +F+ S Sbjct: 48 VLDAQGSVLTNKYAEGYPGKRYYGGC-----EFADEVEALAIERVKRLFNAGHANVQPHS 102 Query: 182 CYVANDAVLSLLGQKMKDLVIFS-DELNHAS-----MIVGIKHANVKKHIFKHN---DLN 232 AN AV+ L + ++ S D H + + G ++ + + D + Sbjct: 103 GAQANGAVMLALAKPGDTVLGMSLDAGGHLTHGAKPALSGKWFNALQYGVSRDTMLIDYD 162 Query: 233 ELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPH 292 ++E L Q + S+ +IA S Y A + +AD GA +D H G+ Sbjct: 163 QVEALAQQHKPSL--IIAGFSAYPRKLDFA---RFRAIADSVGAKLMVDMAHIAGVI--- 214 Query: 293 GAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSF-GSVGGYVAAS-R 350 G ++ ++T T K+ G GG+V + Sbjct: 215 ------------------------AAGRHANPVEHAHVVTSTTHKTLRGPRGGFVLTNDE 250 Query: 351 KLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDL-RTSQQKHTMYVKKAFHELG 409 ++ S + L + A A + + G Sbjct: 251 EIAKKINSAVFPGLQGGPLMHVIAGKAVAFGEALTDDFKTYIDRVLANAQALGDVLKAGG 310 Query: 410 IPVIP--NPSHIVPVLIGNADLAKQASDILINKHQIYV--QAINF-PTVARGTERLRITP 464 + ++ +H++ V + L + + + I I F P T +R+ Sbjct: 311 VDLVTGGTDNHLLLVDLRPKGLKGAQVEQALERAGITCNKNGIPFDPEKPTITSGIRLGT 370 Query: 465 TPGHT 469 G T Sbjct: 371 PAGTT 375 >2CTZ-A nrPDB Length = 421 Score = 45.6 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 27/147 (18%), Positives = 53/147 (36%), Gaps = 12/147 (8%) Query: 145 CGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLV--- 201 G +R + LE LA L + AL +S + A L+ L Q ++V Sbjct: 48 FGNIYSRIMNPTVDV---LEKRLAALEGGKAALATASGHAAQFLALTTLAQAGDNIVSTP 104 Query: 202 -IFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGS 260 ++ N + + + + + E L ++ ES+ + A + Sbjct: 105 NLYGGTFNQFKVTLK-RLGIEVRFTSREERPEEFLALTDEKTRAW----WVESIGNPALN 159 Query: 261 VADIEKICDLADKYGALTFLDEVHAVG 287 + D+E + A + G +D +G Sbjct: 160 IPDLEALAQAAREKGVALIVDNTFGMG 186 >5W1B-A nrPDB Length = 467 Score = 44.8 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 41/280 (14%), Positives = 95/280 (33%), Gaps = 42/280 (15%) Query: 230 DLNELEQLLQSYPKS-VPKLIAFESVYSMAG---SVADIEKICDLADKYGALTFLDEVHA 285 D+ +L++ + + + +++ + S G S+++++++ ++A ++G +D Sbjct: 168 DIKKLKENIAQHGADNIVAIVSTVTCNSAGGQPVSMSNLKEVYEIAKQHGIFVVMDSAR- 226 Query: 286 VGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGY 345 + + + + A T+ + D + +GG Sbjct: 227 ---FCENAYFIKARDPKYKNATIKEVIFDMYKYADALTMSAKKDPLLN--------IGGL 275 Query: 346 VAA--SRKLIDWFRSFAPG---FIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMY 400 VA + ++ R F+ L MA + + + + Y Sbjct: 276 VAIRDNEEIFTLARQRCVPMEGFVTYGGLAGRDMAAMVQGLE-EGTEEEYLHYRIGQVKY 334 Query: 401 VKKAFHELGIP---------VIPNPSHIVPVLIGNADLAKQASDILINKHQIYVQAI--- 448 + E GIP V + +VP + G+ A+ + L + + I Sbjct: 335 LGDRLREAGIPIQYPTGGHAVFVDCKKLVPQIPGDQFPAQAVINALYLESGVRAVEIGSF 394 Query: 449 ---NFPTVA----RGTERLRITP-TPGHTNDLSDILINAV 480 P E +R+T +TND D + +A+ Sbjct: 395 LLGRDPATGEQKHADMEFMRLTIARRVYTNDHMDYIADAL 434 >3PGY-A nrPDB Length = 415 Score = 44.8 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 63/370 (17%), Positives = 110/370 (29%), Gaps = 67/370 (18%) Query: 142 KYGCGAGGTRNIAGHN--IPTLNLE-AELATLHKKEGALVF-SSCYVANDAVLSLLGQKM 197 KY G G R G T ++ L E V S AN AV L Sbjct: 53 KYAEGYPGRRYYGGCEFVDVTESIAIDRAKALFGAEHVNVQPHSGPQANMAVY--LVALE 110 Query: 198 KDLVIFSDELNHASMIVGIKHANVKKHIFK---HN-------------DLNELEQLLQSY 241 + L+H G + F +N + +E+ +L + Sbjct: 111 MGDTVLGMNLSH-----GGHLTHGAPVNFSGKFYNFVEYGVDKDTERINYDEVRKLALEH 165 Query: 242 PKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCD 301 + ++A S YS +K ++AD+ A +D H GL AG+ + Sbjct: 166 KPKL--IVAGASAYSRTIDF---KKFKEIADEVNAKLMVDMAHIAGLV---AAGLHPNP- 216 Query: 302 FESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSF-GSVGGYVAASRKLIDWFRSFA 360 ++ D +T T K+ G GG + + Sbjct: 217 -----------------------VEYADFVTTTTHKTLRGPRGGMILCKEEYKKDIDKTI 253 Query: 361 PGFIFTTTLPPSVMAGATAAIRYQRCHIDL-RTSQQKHTMYVKKAFHELGIPV--IPNPS 417 I L + A A A + + K+ + +A G + + Sbjct: 254 FPGIQGGPLEHVIAAKAVAFGEALENNFKTYQQQVVKNAKVLAEALINEGFRIVSGGTDN 313 Query: 418 HIVPVLI-GNADLAKQASDILINKHQIYVQAINFP---TVARGTERLRITPTPGHTNDLS 473 H+V V + G+ L + ++ ++ I P T +R+ T Sbjct: 314 HLVAVDVKGSIGLTGKEAEETLDSVGITCNKNTIPFDQEKPFVTSGIRLGTPAATTRGFD 373 Query: 474 DILINAVDDV 483 + V + Sbjct: 374 EKAFEEVAKI 383 >3MKJ-A nrPDB Length = 398 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 50/288 (17%), Positives = 90/288 (31%), Gaps = 52/288 (18%) Query: 132 VLDAMHKTIDKYGCGAGG---TRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDA 188 V D+ + ++ G TR LE +LA L + E L +S A Sbjct: 38 VFDSAEQGAARFALEESGYIYTRLGNPTTD---ALEKKLAVLERGEAGLATASGISAITT 94 Query: 189 VLSLLGQKMKDLV----IFSD---ELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSY 241 L L Q+ +V I+ L+H+ GI + V E+ ++ Sbjct: 95 TLLTLCQQGDHIVSASAIYGCTHAFLSHSMPKFGINVSFVDAAK-----PEEIRAAMR-- 147 Query: 242 PKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCD 301 K++ E+ + S+ DIE + +A + GAL +D Sbjct: 148 --PETKVVYIETPANPTLSLVDIETVAGIAHQQGALLVVD-------------------- 185 Query: 302 FESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAP 361 + + GA V+ V G +GG + ++ ID R Sbjct: 186 ----NTFMSPYCQQPLQLGADIVVHSVTKYINGHGD---VIGGIIVGKQEFIDQARFVGL 238 Query: 362 GFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELG 409 I + P A +R + ++ + + + Sbjct: 239 KDITGGCMSPF---NAWLTLRGVKTLGIRMERHCENALKIARFLEGHP 283 >5V1X-E nrPDB Length = 501 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 19/123 (15%), Positives = 40/123 (32%), Gaps = 21/123 (17%) Query: 172 KKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHND- 230 K+ L F + + A + + D+ GI + I+ D Sbjct: 130 GKDEILYFDTIFGACGKTI---------DYVIEDKR-------GIVSSRCIPLIYPAEDD 173 Query: 231 --LNELEQLLQSYPKSV--PKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAV 286 + ++ + P+L + V SM G E I + + ++ +D + Sbjct: 174 DVVAAFRDAIKKSREEGKRPRLAVIDVVSSMPGVRFPFEDIVKICKEEEIISCVDGAQGI 233 Query: 287 GLY 289 G+ Sbjct: 234 GMV 236 >4RAE-A nrPDB Length = 394 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 51/308 (16%), Positives = 107/308 (34%), Gaps = 47/308 (15%) Query: 157 NIPTLNLEAELATLHKKEGALV--FSSCYVANDA------VLSLLGQKMKDLVIFSDELN 208 + + L A+LA + + + + AN + +L G + + F + Sbjct: 70 DRDAVALRADLAGYLTAQTGIQLGVENIWAANGSNEILQQLLQAFGGPGRSAIGFVPSYS 129 Query: 209 -HASMIVGIKHANVKKHIFKHNDLN-ELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEK 266 H + G ++ ND +++ + + P ++ S + +G + Sbjct: 130 MHPIISDGTHTEWIEASRA--NDFGLDVDVAVAAVVDRKPDVVFIASPNNPSGQSVSLPD 187 Query: 267 ICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMD 326 +C L D + +DE + E S + P Sbjct: 188 LCKLLDVAPGIAIVDEAYG------------EFSSQPSAVSLVEEYPSKL---------- 225 Query: 327 RVDMITGTLGKSFGSVG---GYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRY 383 ++T T+ K+F G GY+ A+ +ID + ++ A A AA+R+ Sbjct: 226 ---VVTRTMSKAFAFAGGRLGYLIATPAVIDAMLLVRLPYHLSS----VTQAAARAALRH 278 Query: 384 QRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIVPVLIGNADLAKQASDILINKHQI 443 + + V + +++G VIP+ ++ VL G A A + + I Sbjct: 279 SDDTLSSVAALIAERERVTTSLNDMGFRVIPSDANF--VLFGEFADAPAAWRRYL-EAGI 335 Query: 444 YVQAINFP 451 ++ + P Sbjct: 336 LIRDVGIP 343 >4E3Q-A nrPDB Length = 473 Score = 44.4 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 60/425 (14%), Positives = 110/425 (25%), Gaps = 101/425 (23%) Query: 128 KHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVF--SSCYVA 185 H ++DA +++ G + T+ L +L + + VF +S A Sbjct: 84 DHKGLIDAAKAQYERF---PGYHAFFGRMSDQTVMLSEKLVEVSPFDSGRVFYTNSGSEA 140 Query: 186 NDAVLSLL-----GQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDL--------- 231 ND ++ +L + N G+ + +N + Sbjct: 141 NDTMVKMLWFLHAAEGKPQKRKILTRWN---AYHGVTAVSASMTGKPYNSVFGLPLPGFV 197 Query: 232 -------------------------NELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEK 266 ELE+ +Q E V G + + Sbjct: 198 HLTCPHYWRYGEEGETEEQFVARLARELEETIQREGADTIAGFFAEPVMGAGGVIPPAKG 257 Query: 267 ----ICDLADKYGALTFLDEV-HAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGA 321 I + KY DEV G G + + K Sbjct: 258 YFQAILPILRKYDIPVISDEVICGFGRTG---------NTWGCVTYDFTPDAIISSKNLT 308 Query: 322 KTVMDRVDMITGT-LGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAA 380 +I G L K I+ F FT + P A A A Sbjct: 309 AGFFPMGAVILGPELSKRL----------ETAIEAIEEF--PHGFTASGHPVGCAIALKA 356 Query: 381 IRYQRCHIDLRTSQQKHTMYVKKAF------------HELGIPVIPN---PSHIVPVLIG 425 I L + ++ ++ +G G Sbjct: 357 IDVVMNEG-LAENVRRLAPRFEERLKHIAERPNIGEYRGIGFMWALEAVKDKASKTPFDG 415 Query: 426 NADLAKQASDILINKHQIYVQAINFPTVARGTERLRITP---TPGHTNDLSDILINAVDD 482 N ++++ ++ + + + G + P T +++ D L A+D Sbjct: 416 NLSVSERIANTCTD-LGLICR-------PLGQSVVLCPPFILTEAQMDEMFDKLEKALDK 467 Query: 483 VFNEL 487 VF E+ Sbjct: 468 VFAEV 472 >2FNU-A nrPDB Length = 375 Score = 44.0 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 26/130 (20%), Positives = 46/130 (35%), Gaps = 9/130 (6%) Query: 162 NLEAELATLHKKEGALVFSSCYVANDAVLS----LLGQKMKDLVIFSDELNHASMIVGIK 217 E L + ALVF+S A + + + + + A+M++ Sbjct: 36 LFEEALCEFLGVKHALVFNSATSALLTLYRNFSEFSADRNEIITTPISFVATANMLLESG 95 Query: 218 HANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGAL 277 + V I +++EL L+ K I AG ++E + L K+ Sbjct: 96 YTPVFAGIKNDGNIDELA--LEKLINERTKAIVS---VDYAGKSVEVESVQKLCKKHSLS 150 Query: 278 TFLDEVHAVG 287 D HA+G Sbjct: 151 FLSDSSHALG 160 >3WGB-A nrPDB Length = 341 Score = 43.7 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 33/191 (17%), Positives = 58/191 (30%), Gaps = 13/191 (6%) Query: 162 NLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVG-IKHAN 220 LEA A L KE AL S ++N + Q+ + V+ S + G + Sbjct: 43 ALEAYGADLLGKEAALFVPSGTMSNLLAVMSHCQRGEGAVLGSAAHIYRYEAQGSAVLGS 102 Query: 221 VKKHIFKHN-----DLNELEQLLQSYPK--SVPKLIAFESVYSMAGSVADIE---KICDL 270 V L ++ + + +L+ E+ + G V + ++ +L Sbjct: 103 VALQPVPMQADGSLALADVRAAIAPDDVHFTPTRLVCLENTH--NGKVLPLPYLREMREL 160 Query: 271 ADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDM 330 D++G LD G V E + ++ G Sbjct: 161 VDEHGLQLHLDGARLFNAVVASGHTVRELVAPFDSVSICLSKGLGAPVGSLLVGSHAFIA 220 Query: 331 ITGTLGKSFGS 341 L K G Sbjct: 221 RARRLRKMVGG 231 >1IBJ-A nrPDB Length = 464 Score = 43.7 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 30/134 (22%), Positives = 59/134 (44%), Gaps = 6/134 (4%) Query: 150 TRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNH 209 TR+ LE+ LA L K + A F+S +A + ++ L + +++V D Sbjct: 128 TRSGNPTRD---ALESLLAKLDKADRAFCFTSG-MAALSAVTHLIKNGEEIVAGDDVYGG 183 Query: 210 ASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICD 269 + ++ + + N +L+++ + KL+ ES + ++DI KI + Sbjct: 184 SDRLLSQVVPRSGVVVKRVN-TTKLDEVAAAIGPQ-TKLVWLESPTNPRQQISDIRKISE 241 Query: 270 LADKYGALTFLDEV 283 +A GAL +D Sbjct: 242 MAHAQGALVLVDNS 255 >3KGX-A nrPDB Length = 393 Score = 43.3 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 46/284 (16%), Positives = 89/284 (31%), Gaps = 41/284 (14%) Query: 215 GIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKY 274 G + + K +H L E+E+ L + + L+ E S G V ++ +L +Y Sbjct: 121 GARVHQMIKKPGEHYTLQEVEEGLAQHKPVLLFLVHGE---SSTGVVQPLDGFGELCHRY 177 Query: 275 GALTFLDEVHAVG----LYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDR--- 327 L +D V ++G G + + A + + + V R Sbjct: 178 QCLLLVDSVASLGGVPIYMDQQGIDIMYSSSQKVLNAPPGISLISFNDKAKYKVYSRKTK 237 Query: 328 -VDMIT--GTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQ 384 V T L K +G G T P + + ++ Sbjct: 238 PVSFYTDITYLAKLWGCEGETRVIHH-----------------TTPVTSLYCLRESLALI 280 Query: 385 --RCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIV-PVLIGNADLA----KQASDIL 437 + + ++ T ++ K E+G+ I P + A + + Sbjct: 281 AEQGLENCWRRHREATAHLHKHLQEMGLKFFVKDPEIRLPTITTVTVPAGYNWRDIVSYV 340 Query: 438 INKHQIYVQAINFPTVARGTERLRITPTPGH-TNDLSDILINAV 480 ++ I + PT LRI + T + D + A+ Sbjct: 341 LDHFSIEISGGLGPT---EERVLRIGLLGYNATTENVDRVAEAL 381 >3NYS-A nrPDB Length = 367 Score = 42.9 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 40/235 (17%), Positives = 71/235 (30%), Gaps = 44/235 (18%) Query: 133 LDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSL 192 +DA + + ++G G LE LA + + ++ A ++ + Sbjct: 18 IDAGIQRVLRHGQYILGPEV--------TELEDRLADFVGAKYCISCANGTDA-LQIVQM 68 Query: 193 LGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLN----ELE-QLLQSYPKSVPK 247 + + + + + K + D++ L+ QLL++ K Sbjct: 69 ALGVGPGDEVITPGFTYVATAETVALLGAKPV---YVDIDPRTYNLDPQLLEAAITPRTK 125 Query: 248 LIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRA 307 I S+Y G AD + I +A KYG D + G Sbjct: 126 AIIPVSLY---GQCADFDAINAIASKYGIPVIEDAAQSFG-------------------- 162 Query: 308 SGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPG 362 A+ K TV + LG +G G +L R A Sbjct: 163 ---ASYKGKRSCNLSTVACTSFFPSAPLG-CYGDGGAIFTNDDELATAIRQIARH 213 >4PIW-A nrPDB Length = 396 Score = 42.9 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 40/261 (15%), Positives = 80/261 (30%), Gaps = 19/261 (7%) Query: 143 YGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVI 202 Y A G+ + G T + L L+ SC A+ + +LL + Sbjct: 36 YMQSAMGSGKLCGDGGFTRRCQQWLEQRFGSAKVLLTPSCT-ASLEMAALLLDIQPGDEV 94 Query: 203 FSDEL-----NHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSM 257 +A ++ G K V + +N E L+++ ++I V+ Sbjct: 95 IMPSYTFVSTANAFVLRGAKIVFVDVRP---DTMNIDETLIEAAITDKTRVIV--PVH-Y 148 Query: 258 AGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTND 317 AG +++ I LA K+ D V + G + Sbjct: 149 AGVACEMDTIMALAKKHNLFVVEDAAQGV-MSTYKGRALGTIGHIGCFSFHETKNYTAGG 207 Query: 318 KGGAKTVMDRVDMITGTLGKSFGS-VGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAG 376 +GGA + D+ + + + G+ + W R ++ + A Sbjct: 208 EGGATLINDKALIERAEIIREKGTNRSQFFRGQVDKYTW-RDIGSSYLMSD----LQAAY 262 Query: 377 ATAAIRYQRCHIDLRTSQQKH 397 A + R + ++ Sbjct: 263 LWAQLEAADRINQQRLALWQN 283 >5LUC-A nrPDB Length = 403 Score = 42.9 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 42/284 (14%), Positives = 94/284 (33%), Gaps = 32/284 (11%) Query: 147 AGGTRNIAGHNIPTLNLEAELATLHKK------EGALVFS-SCYVANDAVLSLLGQKMKD 199 AGG + I + + E+ + LV S S + A +A L + + Sbjct: 51 AGGLQMIGSMSKDMYQIMDEIKEGIQYVFQTRNPLTLVISGSGHCALEAALVNVLEPGDS 110 Query: 200 LVIFSDELNHASMIV-----GIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESV 254 ++ ++ + + G + + K H L E+E+ L + + L E Sbjct: 111 FLVGANGIWGQRAVDIGERIGARVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFLTHGE-- 168 Query: 255 YSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPK 314 S G + ++ +L +Y L ++ V ++G G + D + + K Sbjct: 169 -SSTGVLQPLDGFGELCHRYKCLLLVNSVASLG-------GTPLYMDRQGIDILYSGSQK 220 Query: 315 TNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSF----APGFIFTTTLP 370 + +++ D K S + I W +F ++ T+P Sbjct: 221 ALNAPPGTSLISFSDKAK----KKMYSRKTKPFSFYLDIKWLANFWGCDDQPRMYHHTIP 276 Query: 371 PSVMAGATAAIRYQ--RCHIDLRTSQQKHTMYVKKAFHELGIPV 412 + ++ + + ++ Y+ LG+ + Sbjct: 277 VISLYSLRESLALIAEQGLENSWRQHREAAAYLHGRLQALGLQL 320 >5X5H-A nrPDB Length = 392 Score = 42.9 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 32/164 (19%), Positives = 60/164 (36%), Gaps = 9/164 (5%) Query: 121 NDYLALSKHPEVLDA--MHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALV 178 +DY P ++ G TR + LE +A L + Sbjct: 22 DDYYGSINTPIYASTTFAQNAPNELRKGYEYTRVGNPTI---VALEQTVAALEGAKYGRA 78 Query: 179 FSSCYVANDAVLSLLGQKMKDLVIFSDELNHA-SMIVGIKHANVKKHIFKHNDLNELEQL 237 FSS A D + ++ + +V+ +D +I + + D + +E+ Sbjct: 79 FSSGMAATDILFRIILKPGDHIVLGNDAYGGTYRLIDTV--FTAWGVEYTVVDTSVVEE- 135 Query: 238 LQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLD 281 +++ K KLI E+ + A + DIE + L + A +D Sbjct: 136 VKAAIKDNTKLIWVETPTNPALGITDIEAVAKLTEGTNAKLVVD 179 >3OP7-A nrPDB Length = 375 Score = 42.5 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 55/326 (16%), Positives = 111/326 (34%), Gaps = 63/326 (19%) Query: 149 GTRNIAGHNIPTLNLEAELATLHK--KEGALVFSSC-YVANDAVLSLLGQKMKDLVIFSD 205 GT+ G + + ++ L+ K ++ ++ AN VL L + S Sbjct: 54 GTKLNYGWIEGSPAFKKSVSQLYTGVKPEQILQTNGATGANLLVLYSL--IEPGDHVISL 111 Query: 206 ELNHASMIVGIKHANVKK---HIFKHN----DLNELEQLLQSYPKSVPKLIAFESVYSMA 258 + + K + I + N DL +L QL++ K+I + + Sbjct: 112 YPTYQQLYDIPKSLGAEVDLWQIEEENGWLPDLEKLRQLIR----PTTKMICINNANNPT 167 Query: 259 GSVAD---IEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKT 315 G+V D +E++ ++A + GA DEV+ + Sbjct: 168 GAVMDRTYLEELVEIASEVGAYILSDEVY--------------------------RSFSE 201 Query: 316 NDKGGAKTVMDRVDMITGTLGKSF---GSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPS 372 D V D+ + +L K++ G G+VAA+ ++ D R + + Sbjct: 202 LDVPSIIEVYDK-GIAVNSLSKTYSLPGIRIGWVAANHQVTDILRDY-RDYTMICAGVFD 259 Query: 373 VMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIVPVLIGNADLAKQ 432 + A YQ R +++ + + E + S+I P ++ + + Sbjct: 260 DLVAQLALAHYQEILERNRHILEENLAILDQWIEEEPLV-----SYIRPAVVSTSFVKIA 314 Query: 433 A-------SDILINKHQI-YVQAINF 450 L+ +H + V F Sbjct: 315 VDMPMEDFCLQLLQEHGVLLVPGNRF 340 >4U1T-A nrPDB Length = 389 Score = 42.5 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 28/127 (22%), Positives = 48/127 (37%), Gaps = 3/127 (2%) Query: 155 GHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIV 214 G N LE LA L + A VFSS A +LSL+ + + Sbjct: 49 GENPTREELEECLAGLERAPFATVFSSGQAAAATLLSLVRPGQCVVSTDDVYAGTDGLFD 108 Query: 215 GIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKY 274 A + ++ DL E + + + L+ E+ + +V D+ ++ A + Sbjct: 109 ---LAARQGVRVRYADLTTPEGIAAALAEPDLALVWIETPTNPLLTVVDVAEVSRRAHER 165 Query: 275 GALTFLD 281 GA +D Sbjct: 166 GARVVVD 172 >5DDW-A nrPDB Length = 523 Score = 42.5 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 50/279 (17%), Positives = 82/279 (29%), Gaps = 65/279 (23%) Query: 240 SYPKSVPKLIAFESVYSMAG--SVAD--IEKICDLADKYGALTFLDEVHAVGLYGPHGAG 295 V I E V +G +V E++ L D G +DEV G Sbjct: 270 ERDFPVVAAIFVEPVRGGSGMKTVTPELAEELHRLRDTLGCPLVVDEVQT---------G 320 Query: 296 VAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDW 355 + F GI TL K+ G GG V S LI Sbjct: 321 IGRTGAFFGSALLGIRGDYY------------------TLAKAIG--GGIVKNSVALIRQ 360 Query: 356 FRSF-APGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIP 414 R A I ++T ++ + A ++ + + + V Sbjct: 361 DRFLPAMEVIHSSTFAKDGLSASIA-LKVLEMVEADGGRVYQRVRERGQRLEAMLESVRA 419 Query: 415 NPSHIVP----------VLIGNADLAKQ---------------ASDILINKHQIYVQAIN 449 + S +V + + + A + L+ +H I V Sbjct: 420 DHSDVVSAVWGTGLMLALELRDQSNATSQAIREKAAHGFLGYVLAGFLLREHHIRV---- 475 Query: 450 FPTVARGTERLRITPTPGHTNDLSDILINAVDDVFNELQ 488 P R LR +P+ T++ D A+ +F L+ Sbjct: 476 LPAGPRSGF-LRFSPSLYITDEEIDRTETALRSLFTALR 513 >1QZ9-A nrPDB Length = 416 Score = 42.1 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 37/199 (18%), Positives = 74/199 (37%), Gaps = 14/199 (7%) Query: 99 LAKEFPLAHRQREADKVTVWCSNDYLALSKHPEVLDAMHKT--IDKYGCGAGGTRNIAGH 156 PL + + V N L P A + +++G G + N AG Sbjct: 13 QDSLAPLRQQFALPEGVIYLDGNS---LGARPVAALARAQAVIAEEWGNGLIRSWNSAGW 69 Query: 157 NIPTLNLEAELATLHKK-EGALVFSSCYVAND-----AVLSLLGQKMKDLVIFSDELNH- 209 + L LATL +G +V + N A L + + + + E ++ Sbjct: 70 RDLSERLGNRLATLIGARDGEVVVTDTTSINLFKVLSAALRVQATRSPERRVIVTETSNF 129 Query: 210 -ASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKIC 268 + + A++ + + ++ E+L Q+ + ++ Y G + D++ + Sbjct: 130 PTDLYIAEGLADMLQQGYTLRLVDSPEELPQAIDQDTAVVMLTHVNYKT-GYMHDMQALT 188 Query: 269 DLADKYGALTFLDEVHAVG 287 L+ + GAL D H+ G Sbjct: 189 ALSHECGALAIWDLAHSAG 207 >4PPM-A nrPDB Length = 861 Score = 41.7 bits (96), Expect = 7e-04, Method: Composition-based stats. Identities = 72/417 (17%), Positives = 130/417 (31%), Gaps = 68/417 (16%) Query: 21 RLSTTAAPHAKNGYATATGAGAAAATATASSTHAAAAAAAAANHSTQESGFDYEGLI--- 77 R+ + + K Y AG +A A +S A A A + +++ Y I Sbjct: 346 RIDRQSVTNLKRYYHHDIYAGESADAALPASRLAFIDAVIAQTPAREDTLDRYHQYINPM 405 Query: 78 -DSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPE-VLDA 135 L+ +R D +R + + + D V + L L +P+ V++A Sbjct: 406 MVDFLKLQRCDNVFR-----SAAGTQLYDDAGEAFLDMVAGYGC---LNLGHNPQPVVNA 457 Query: 136 MHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLH------KKEGALVFSSCYVANDAV 189 + +D A G I I A+LA + +S A +A Sbjct: 458 LKNYLD-----AQGPNFI--QYISIPEQTAKLAEVLCRLAPGNMGRVFFSNSGTEAVEAA 510 Query: 190 LS-LLGQKMKDLVIFSDELNHASMIVGIKHANVKKHI------------FKHNDLNELEQ 236 + K + + H + + KH DL L + Sbjct: 511 MKIAKASTGKPGIAYLRNSYHGKTLGALSITGRDKHRRYFTPLLDAMVEVPFGDLAALRE 570 Query: 237 LLQSYPKSVPKLIAFESVYSMAGS-VAD---IEKICDLADKYGALTFLDEVHAVGLYGPH 292 L + E + G + ++ + L + G L +DEV G G Sbjct: 571 ALNRED---VGALMIEPIQGEGGVHIPPAGYLQAVQQLCRETGVLLMVDEVQ-TG-LGRT 625 Query: 293 GAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKL 352 G A D ++ + + R D+ K++G+ ++ S Sbjct: 626 GKLFACEWDGIEPDVLMLSKSLSGGLIPIGATLCRADLWQ----KAYGTADRFLVHSST- 680 Query: 353 IDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELG 409 + SV+A +A+R DL ++ Y K+A E+ Sbjct: 681 ------------YGGGNLASVVA--LSALREIL-AQDLVGHAERMGAYFKQALSEIA 722 >5O5C-A nrPDB Length = 519 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 32/192 (16%), Positives = 69/192 (35%), Gaps = 41/192 (21%) Query: 131 EVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELA--TLHKKEGALVFSSCYVANDA 188 +++ A++ ++D + AGG I ++ L+ L + S +N Sbjct: 123 QIMAAVNSSVDTWDQSAGG------TLIEQKVIDWTLSRIGLPAGADGIFTSGGTQSNLM 176 Query: 189 VLSL-------------------LGQKMKDLVIFSDELNHASM-----IVGIKHANVKKH 224 + L L +F+ +L+H S+ I+G+ + V Sbjct: 177 AMLLARDSWCAAHHPGHLIKHRGLPHDAAKWRVFTSKLSHFSIQKSMAILGLGYDAVIPV 236 Query: 225 IFKHN---DLNELEQLLQSYPKSV---PKLIAFESVYSMA-GSVADIEKICDLADKYGAL 277 + D++ L+Q +Q + ++A + GS+ + I +L +G Sbjct: 237 DYDERYRMDVDCLKQEVQRCLQQGLIPVAVVATSG--TTDFGSIDPLGAISELCKHHGMW 294 Query: 278 TFLDEVHAVGLY 289 +D + GL Sbjct: 295 MHVDAAYGCGLL 306 >5VC2-A nrPDB Length = 424 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 73/411 (17%), Positives = 139/411 (33%), Gaps = 61/411 (14%) Query: 102 EFPLAHRQREADKVTVWCSNDYLALSKHPEVLDAMHKTI-DKYGCGAGGTRNIAGHNI-- 158 E +R+ + + + S +Y P V++AM + +KY G R G + Sbjct: 22 ELIFEEYKRQNEHLEMIASENY----TFPSVMEAMGSILTNKYAEGYPNKRYYGGCEVVD 77 Query: 159 --PTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLV-IFSDELNHASMIVG 215 +L +E + + + S AN+AV L + ++ + H + Sbjct: 78 KIESLAIERAKKLFNCQFANVQAHSGSQANNAVYHALLKPYDKILGMDLSCGGHLTHGAK 137 Query: 216 IKHANVKKHIFKHN-DLN---ELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLA 271 + F + +L+ + E+ L+ P++I +S D +K ++A Sbjct: 138 VSLTGKHYQSFSYGVNLDGYIDYEEALKIAQSVKPEIIVCG--FSAYPREIDFKKFREIA 195 Query: 272 DKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMI 331 D+ GAL D H GL + EH H ++ Sbjct: 196 DEVGALLLGDIAHVAGLVVTN-----EHAHPFPHC----------------------HVV 228 Query: 332 TGTLGKSF-GSVGGYVAASRKLIDWFRSFAPGFIFTTT----LPPSVMAGATAAIRYQRC 386 + T K+ G GG + + + I A IF T L + A A + Sbjct: 229 SSTTHKTLRGPRGGIILTNDEEIAAKIDKA---IFPGTQGGPLMHVIAAKAVGFKENLKP 285 Query: 387 HIDLRTSQQK-HTMYVKKAFHELGIPVIPNPS--HIVPVLIGNADLAKQASDILINKHQI 443 K + + KA E ++ + H++ + + + + +DI + I Sbjct: 286 EFKAYAKLVKSNMQVLAKALKEKNHKLVSGGTSNHLLLMDFLDKPYSGKDADIALGNAGI 345 Query: 444 YVQA------INFPTVARGTERLRITPTP-GHTNDLSDILINAVDDVFNEL 487 V P V G + G +I+ N + D+ N++ Sbjct: 346 TVNKNTIPGETRSPFVTSGIRIGSAALSARGMGAKEFEIIGNKISDILNDI 396 >3DR4-A nrPDB Length = 391 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 22/130 (16%), Positives = 44/130 (33%), Gaps = 8/130 (6%) Query: 161 LNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHAN 220 + E A + A+ ++ A L +G + L + + + + Sbjct: 59 VEFEKAFADYCGVKHAIACNNGTTALHLALVAMG-IGPGDEVIVPSLTYIASANSVTYCG 117 Query: 221 VKKHIFKHNDLNEL---EQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGAL 277 + ND L++ K I +Y G + D++ I ++A ++ L Sbjct: 118 A-TPVLVDNDPRTFNLDAAKLEALITPRTKAIMPVHLY---GQICDMDPILEVARRHNLL 173 Query: 278 TFLDEVHAVG 287 D AVG Sbjct: 174 VIEDAAEAVG 183 >2Z9W-A nrPDB Length = 392 Score = 41.3 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 40/255 (15%), Positives = 80/255 (31%), Gaps = 32/255 (12%) Query: 227 KHN---DLNELEQLLQSYPKSVPKLIAFESVYSMA---GSVADIEKICDLADKYGALTFL 280 +N D + +L+++P+ I SV G++ I+ I L +GA + Sbjct: 115 PYNEAIDPQAVADMLKAHPE-----ITVVSVCHHDTPSGTINPIDAIGALVSAHGAYLIV 169 Query: 281 DEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFG 340 D V + G H E C + + V +R K Sbjct: 170 DAVSSFGGMKTH----PEDCKADIYVTGPNKCLGAPPGLTMMGVSERA------WAKMKA 219 Query: 341 SVGGYVAASRKLIDWFRSFAP--GFIFTTTLPPSVMAGATAAIRYQRCHIDLR--TSQQK 396 + A+ ++DW +++ F FT ++ S + G A+ Sbjct: 220 NPLAPRASMLSIVDWENAWSRDKPFPFTPSV--SEINGLDVALDLYLNEGPEAVWARHAL 277 Query: 397 HTMYVKKAFHELGIP-VIPNPSHIVP----VLIGNADLAKQASDILINKHQIYVQAINFP 451 ++ +G+ + S P V + K ++ + + Sbjct: 278 TAKAMRAGVTAMGLSVWAASDSIASPTTTAVRTPDGVDEKALRQAARARYGVVFSSGRGE 337 Query: 452 TVARGTERLRITPTP 466 T+ + T + PT Sbjct: 338 TLGKLTRIGHMGPTA 352 >1V2E-A nrPDB Length = 381 Score = 41.0 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 58/358 (16%), Positives = 117/358 (32%), Gaps = 62/358 (17%) Query: 161 LNLEAELAT-LHKKEGALVFSSC-YVANDAVLSLLGQKMKDLVI---FSDELNHASMIVG 215 L LA + ++V +S A +L L ++V+ F D + + G Sbjct: 64 PALREALAEEFAVEPESVVVTSGATEALYVLLQSLVGPGDEVVVLEPFFDVYLPDAFLAG 123 Query: 216 IKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVAD--IEKICDLADK 273 K V+ + +L L ++ L+ + + +E I LA Sbjct: 124 AKARLVRLDLTPEGFRLDLSALEKALTPRTRALLLNTPMNPTGLVFGERELEAIARLARA 183 Query: 274 YGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITG 333 + DEV+ YG + E + G Sbjct: 184 HDLFLISDEVYDELYYGERPRRLREFAPERT-------------------------FTVG 218 Query: 334 TLGK---SFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVM-AGATAAIRYQRCHI- 388 + GK + G G++ + ++ A +T+ P+ + AG A++ R Sbjct: 219 SAGKRLEATGYRVGWIVGPK---EFMPRLAGMRQWTSFSAPTPLQAGVAEALKLARREGF 275 Query: 389 --DLRTSQQKHTMYVKKAFHELGIPV-IPNPSHIVPVLI---GNADLAKQASDILINKHQ 442 LR ++ + +G+ V +P ++ + + L ++A LI Sbjct: 276 YEALREGYRRRRDLLAGGLRAMGLRVYVPEGTYFLMAELPGWDAFRLVEEARVALIPASA 335 Query: 443 IYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVDDVFNELQLPRVRDWESQGG 500 Y++ + P + R + L A++ + + PR E++GG Sbjct: 336 FYLE--DPP-----KDLFRFAFC-----KTEEELHLALERLGRVVNSPR----EAEGG 377 >5KR5-A nrPDB Length = 479 Score = 41.0 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 31/192 (16%), Positives = 51/192 (26%), Gaps = 36/192 (18%) Query: 231 LNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEK----ICDLADKYGALTFLDE-VHA 285 + ELE+L+ E V G V + I + K+ L DE V Sbjct: 225 VEELEKLIAREGADTIAAFIAEPVMGTGGIVPPPQGYWEAIQAVLRKHDILLIADEVVCG 284 Query: 286 VGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVG-G 344 G G G + A V ++V + + G +G G Sbjct: 285 FGRLGSK-TGSEHYGIKPDLITVAKGLTSAYAPLSAVIVSEKVWDVIEKGSREHGVMGHG 343 Query: 345 YVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQR------CHIDLRTSQQKHT 398 + + P A A A + D+ Q+ Sbjct: 344 WTYSGH--------------------PVCAAAALANLDILERENLTGNAADVGAYLQQ-- 381 Query: 399 MYVKKAFHELGI 410 + +AF + Sbjct: 382 -RLHEAFGAHPL 392 >1MDZ-A nrPDB Length = 393 Score = 40.6 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 47/268 (17%), Positives = 84/268 (31%), Gaps = 29/268 (10%) Query: 160 TLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHA 219 LEA L + A+ SS L LG + + + + S + I Sbjct: 41 NQELEAAFCRLTGNQYAVAVSSATAGMHIALMALG-IGEGDEVITPSMTWVSTLNMIVLL 99 Query: 220 NVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESV----YSMAGSVADIEKICDLADKYG 275 + ++ L P+ + I ++ AG+ AD++ I L ++YG Sbjct: 100 GANPVM-----VDVDRDTLMVTPEHIEAAITPQTKAIIPVHYAGAPADLDAIYALGERYG 154 Query: 276 ALTFLDEVHAVGL------YGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVD 329 D HA G G G + ++ + T++ A + R Sbjct: 155 IPVIEDAAHATGTSYKGRHIGARGTAIFSFHAIKNITCAEGGIVVTDNPQFADKL--RSL 212 Query: 330 MITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHID 389 G ++ G + APG+ + LP A A A ++ Sbjct: 213 KFHGLGVDAWDRQSG---GRAPQAEVL---APGYKYN--LPDLNAAIALAQLQKLDALNA 264 Query: 390 LRTSQQKHTMYVKKAFHELGIPVIPNPS 417 R + +A +L + PS Sbjct: 265 RRAAI---AAQYHQAMADLPFQPLSLPS 289 >3BB8-A nrPDB Length = 437 Score = 40.6 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 26/144 (18%), Positives = 47/144 (32%), Gaps = 18/144 (12%) Query: 156 HNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIF--SDELN----- 208 E +L L +S AN L+ L + DE+ Sbjct: 60 TGRFNDAFEKKLGEYLGVPYVLTTTSGSSANLLALTALTSPKLGVRALKPGDEVITVAAG 119 Query: 209 -----HASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVAD 263 + ++ G+ V I +N L +++ K I + G++ D Sbjct: 120 FPTTVNPTIQNGLIPVFVDVDIPTYNVNASL---IEAAVSDKTKAIM---IAHTLGNLFD 173 Query: 264 IEKICDLADKYGALTFLDEVHAVG 287 + ++ +ADKY D A+G Sbjct: 174 LAEVRRVADKYNLWLIEDCCDALG 197 >3UWC-A nrPDB Length = 374 Score = 40.6 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 19/124 (15%), Positives = 43/124 (34%), Gaps = 6/124 (4%) Query: 161 LNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNH-ASMIVGIKHA 219 E A LH A+ + A A+ + + + AS+ ++ Sbjct: 41 EKFEKRFAALHNAPHAIGVGTGTDA-LAMSFKMLNIGAGDEVITCANTFIASVGAIVQAG 99 Query: 220 NVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTF 279 + N + +++ K I V+ G++AD+ + +A K+ L Sbjct: 100 ATPVLVDSENGYVIDPEKIEAAITDKTKAIM--PVHYT-GNIADMPALAKIAKKHN-LHI 155 Query: 280 LDEV 283 +++ Sbjct: 156 VEDA 159 >3PJ0-A nrPDB Length = 359 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 32/233 (13%), Positives = 79/233 (33%), Gaps = 35/233 (15%) Query: 153 IAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASM 212 I G+ + E ++A + K+ A+ F S +A L + + ++ + L+H + Sbjct: 43 IYGNGAVIEDFETKIAKILGKQSAVFFPSGTMAQQIALRIWADRKENRRVAYHPLSHLEI 102 Query: 213 I--VGIKHAN--VKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKIC 268 G+K + N L ++ ++S + V ++ + G + E++ Sbjct: 103 HEQDGLKELQQITPLLLGTANQLLTIDD-IKSLREPVSSVLIELPQREIGGQLPAFEELE 161 Query: 269 DLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRV 328 +++ E + + + A+ + Sbjct: 162 KISEY----------------------CHEQGISLHLDGARLWEITPFYQKSAEEICALF 199 Query: 329 DMITGTLGKSFGSVGGYV-AASRKLID----WFRSFAPGFIFTTTLPPSVMAG 376 D + + K G + G + A + + W R + I +L P +++ Sbjct: 200 DSVYVSFYKGIGGIAGAILAGNDDFVQEAKIWKRRYGGDLI---SLYPYILSA 249 >4IYO-A nrPDB Length = 397 Score = 40.2 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 36/229 (15%), Positives = 72/229 (31%), Gaps = 9/229 (3%) Query: 139 TIDKYGCGAGGTRNIAGHNIPTL----NLEAELATLHKKEGALVFSSCYVANDAVLSLLG 194 Y + G ++ E +A L A F+S A V+ LL Sbjct: 41 ATSTYAQSSPGEHQGFEYSRTHNPTRFAYERCVAALEGGTRAFAFASGMAATSTVMELLD 100 Query: 195 QKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESV 254 + + + ++ F DL + ++ ++ K++ E+ Sbjct: 101 AGSHVVAMDDLYGGTFRLFERVRRRTAGL-DFSFVDLTD-PAAFKAAIRADTKMVWIETP 158 Query: 255 YSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYG---PHGAGVAEHCDFESHRASGIA 311 + + DI I +A K+G LT +D A + GA + H + Sbjct: 159 TNPMLKLVDIAAIAVIARKHGLLTVVDNTFASPMLQRPLSLGADLVVHSATKYLNGHSDM 218 Query: 312 TPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFA 360 G + +++ + ++G G ++A R A Sbjct: 219 VGGIAVVGDNAELAEQMAFLQNSIGGVQGPFDSFLALRGLKTLPLRMRA 267 >5Z0Y-A nrPDB Length = 470 Score = 40.2 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 64/404 (15%), Positives = 123/404 (30%), Gaps = 77/404 (19%) Query: 97 NRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPEVLDAMHKTI-DKYGCGAGGTRNIAG 155 + + R+ + + S ++ + S V DA+ + +KY G G R G Sbjct: 22 DPEVNQIIKDEVDRQKHSIVLIASENFTSTS----VFDALGTPMCNKYSEGYPGARYYGG 77 Query: 156 HNIPTLN----LEAELATLH--KKEGALVFS--SCYVANDAVLSLLGQKMKD----LVIF 203 + + L H + S AN V + + + Sbjct: 78 NEHIDRMEILCQQRALKAFHLDGSRWGVNVQTLSGSPANLQVYQAIMKPHDRLMGLDLPH 137 Query: 204 SDELNHASMIVGIKHANVKKH--IFKHN-DLN----ELEQLLQSYPKSVPKLIAFESVYS 256 L+H K + V + + DL + + L ++ PK++ + S Sbjct: 138 GGHLSHGYQTDTRKISAVSTYFETMPYRVDLETGIIDYDMLEKTAVLYRPKVLVAGT--S 195 Query: 257 MAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTN 316 + D +++ ++ADK GA +D H GL AGV Sbjct: 196 AYCRLIDYKRMREIADKVGAYLVVDMAHISGLI---AAGVIPSP---------------- 236 Query: 317 DKGGAKTVMDRVDMITGTLGKSF-GSVGGYVAASRKLIDWFRSFAPGFIFTTTLP----- 370 + D++T T KS G G + + + + P Sbjct: 237 --------FEYADIVTTTTHKSLRGPRGAMIFFRKGVRSVNPKTGKEIYYDLENPINFSV 288 Query: 371 -PS--------VMAGATAAIRYQRCHI--DLRTSQQKHTMYVKKAFHELGIPVIPN--PS 417 P +A A++ + K+ ++ F LG ++ + S Sbjct: 289 FPGHQGGPHNHTIAALATALKQAATPEFKQYQEQVLKNAKALENEFKRLGYKLVSDGTDS 348 Query: 418 HIVPVLIGNADLAKQASDILINKHQIY-----VQAINFPTVARG 456 H+V V + + D+ + + I + V G Sbjct: 349 HMVLVSLKDKDIDGARIETVCENINIALNKNSIPGDRSALVPGG 392 >5LH9-A nrPDB Length = 458 Score = 39.8 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 21/112 (18%), Positives = 38/112 (33%), Gaps = 22/112 (19%) Query: 207 LNHASMIVGIKH------------ANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESV 254 NH ++ G + + H + +LE+ + + E V Sbjct: 175 YNHGQLLAGCHLLDTPWLYRNPWDCRDPQALTAHC-IRQLEEQIALLGAQTIAALIAEPV 233 Query: 255 YSMAGSVAD----IEKICDLADKYGALTFLDE-VHAVG----LYGPHGAGVA 297 G + ++ ++ D++G L DE V G + G G GVA Sbjct: 234 QGAGGVIVPPADYWPRLREVCDRHGILLIADEVVTGFGRSGCMLGSRGWGVA 285 >2JJG-A nrPDB Length = 449 Score = 39.8 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 41/253 (16%), Positives = 75/253 (29%), Gaps = 40/253 (15%) Query: 235 EQLLQSYPKSVPKLIAFESVYSMAGS--VAD--IEKICDLADKYGALTFLDEVH-AVGLY 289 ++ P + +A E + G + +L D++ AL DEV GL Sbjct: 222 RAAFETRPHDIACFVA-EPIQGEGGDRHFRPEFFAAMRELCDEFDALLIFDEVQTGCGLT 280 Query: 290 GPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAAS 349 G A + D + + + V + D + + + GG Sbjct: 281 GT--AWAYQQLDVAPDIVAFGKKTQVCGVMAGRRVDEVADNVFAVPSRLNSTWGG----- 333 Query: 350 RKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHEL- 408 L D R A + + Q H Y++ EL Sbjct: 334 -NLTDMVR-------------------ARRILEVIEAEGLFERAVQ-HGKYLRARLDELA 372 Query: 409 -GIPVIPNPSHIVPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPG 467 P + ++ + D LI + ++ +A+ + G + +R P Sbjct: 373 ADFPAVVLDPRGRGLMCAFSLPTTADRDELIRQ--LWQRAVI--VLPAGADTVRFRPPLT 428 Query: 468 HTNDLSDILINAV 480 + D I AV Sbjct: 429 VSTAEIDAAIAAV 441 >5KR3-A nrPDB Length = 479 Score = 39.4 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 23/135 (17%), Positives = 38/135 (28%), Gaps = 13/135 (9%) Query: 231 LNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEK----ICDLADKYGALTFLDE-VHA 285 + ELE+L+ E V G + + I + K+ L DE V Sbjct: 225 VEELEKLIAREGADTIAAFIAEPVMGTGGIIPPPQGYWEAIQAVLRKHDILLIADEVVCG 284 Query: 286 VGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMIT-------GTLGKS 338 G G G + V ++V + G +G Sbjct: 285 FGRLGSK-MGSQHYGIKPDLITVAKGLTSAYAPLSGVIVGEKVWDVIEKGSQEHGPMGHG 343 Query: 339 FGSVGGYVAASRKLI 353 + G + A+ L Sbjct: 344 WTYSGHPICAAAALA 358 >5KQU-A nrPDB Length = 479 Score = 39.4 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 38/210 (18%), Positives = 66/210 (31%), Gaps = 43/210 (20%) Query: 232 NELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEK----ICDLADKYGALTFLDE-VHAV 286 +ELE+L+ + E V G + + I + +KY L DE V A Sbjct: 226 DELEKLILAEGPDTVAAFIGEPVMGTGGIIVPPKGYWEAIQAVLNKYDVLLIADEVVCAF 285 Query: 287 GLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGT--LGKSFGSVGG 344 G G K G++ R D+IT L ++ + Sbjct: 286 GRLGS--------------------------KMGSQRYGMRPDLITTAKGLTSAYAPLSA 319 Query: 345 YVAASR--KLIDWFRSF--APGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMY 400 + + +I+ A G +T + P A A A + R + + Sbjct: 320 VIVGEKVWDVIEKASQKEGAMGHGWTYSGHPICAAAALANLDILE-----RENLTANAAD 374 Query: 401 VKKAFHELGIPVIPNPSHIVPVLIGNADLA 430 V ++ +V + G+ LA Sbjct: 375 VGAYLNQRLRETF-EGHPLVGEVRGDGMLA 403 >1ECX-A nrPDB Length = 384 Score = 39.0 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 57/379 (15%), Positives = 124/379 (32%), Gaps = 57/379 (15%) Query: 141 DKYGCGAGGTRNIAGHNIPTLNLEAELATLHKK-EGALVFSSCYVANDA-VLSLLGQKMK 198 +KYG N+ ++A + + F+SC + +L + + + Sbjct: 27 EKYGNPNSAHGMGIEANLHMEKAREKVAKVLGVSPSEIFFTSCATESINWILKTVAETFE 86 Query: 199 DLV--IFSDELNHASMIVGIKHANVKKHIFKHN--------DLNELEQLLQSYPKSVPKL 248 I + + H +++ +K+ ++K K+ L ELE+L+ V + Sbjct: 87 KRKRTIITTPIEHKAVLETMKYLSMKGFKVKYVPVDSRGVVKLEELEKLVDEDTFLVSIM 146 Query: 249 IAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRAS 308 A V G++ +E + + K T + V AV G + + + Sbjct: 147 AANNEV----GTIQPVEDVTRIVKKKNKETLV-HVDAVQTIGK----IPFSLEKLEVDYA 197 Query: 309 GIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTT 368 + K + G R + L G G + ++ + Sbjct: 198 SFSAHKFHGPKGVGITYIRKGVPIRPLIHGGGQERGLRSGTQNV---------------- 241 Query: 369 LPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIVP--VLIGN 426 P ++ A A + +K + LG +I +P + + Sbjct: 242 --PGIVGAARAMEIAVEELSEAAKHMEKLRSKLVSGLMNLGAHIITPLEISLPNTLSVSF 299 Query: 427 ADLAKQASDILINKHQIYVQA----------INFPTVARGTER------LRITPTPGHTN 470 ++ L++ + IYV + A G +R +RI+ +T Sbjct: 300 PNIRGSTLQNLLSGYGIYVSTSSACTSKDERLRHVLDAMGVDRRIAQGAIRISLCKYNTE 359 Query: 471 DLSDILINAVDDVFNELQL 489 + D + ++++ + L L Sbjct: 360 EEVDYFLKKIEEILSFLDL 378 >6IO1-A nrPDB Length = 451 Score = 39.0 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 34/178 (19%), Positives = 53/178 (29%), Gaps = 39/178 (21%) Query: 231 LNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEK----ICDLADKYGALTFLDEV-HA 285 + ELE+ ++ E V G V + I + KYG L LDEV Sbjct: 206 VQELEETIEREGSETIAAFIGEPVQGAGGVVVPPDGYWPAIAAVLRKYGILLILDEVITG 265 Query: 286 VGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVG-G 344 G G G + + D++T G + G V G Sbjct: 266 FGRTGT--------------------------LFGMQQYGVQPDIVTFAKGITSGYVPLG 299 Query: 345 YVAASRKLIDWFRSFAPGFI--FTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMY 400 V S ++ + S F+ FT + P A A + ++ Sbjct: 300 GVGVSDEIAETLASADRVFMHGFTYSGHPVACAVALRNLDILLAE-----RLWENAAA 352 >3GJU-A nrPDB Length = 460 Score = 38.6 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 37/243 (15%), Positives = 66/243 (27%), Gaps = 46/243 (18%) Query: 116 TVWCSNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEG 175 +W N+ L + +++ Y T ++ G ++ + A + E Sbjct: 131 LIWYYNNVLGRPEKKKIISRW----RGYHGSGVMTGSLTGLDLFHNAFDLPRAPVLHTEA 186 Query: 176 ALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELE 235 F + ++ +H E Sbjct: 187 PYYFRR----------------------------------TDRSMSEEQFSQHCADKLEE 212 Query: 236 QLLQSYPKSVPKLIAFESVYSMAGSVAD----IEKICDLADKYGALTFLDE-VHAVGLYG 290 +L P+++ I E + G V EKI + KY L DE V G G Sbjct: 213 MILAEGPETIAAFIG-EPILGTGGIVPPPAGYWEKIQAVLKKYDVLLVADEVVTGFGRLG 271 Query: 291 PHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVG-GYVAAS 349 G + V DRV + GS+G G+ ++ Sbjct: 272 TM-FGSDHYGIKPDLITIAKGLTSAYAPLSGVIVADRVWQVLVQGSDKLGSLGHGWTYSA 330 Query: 350 RKL 352 + Sbjct: 331 HPI 333 >3A8U-X nrPDB Length = 449 Score = 38.6 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 47/268 (17%), Positives = 92/268 (34%), Gaps = 38/268 (14%) Query: 232 NELEQLLQSYPKSVPKLIAFESVYSMAGSVAD----IEKICDLADKYGALTFLDEV-HAV 286 +EL +L++ + S + E + AG + +++ ++ +++ L DEV Sbjct: 206 DELLKLIELHDASNIAAVFVEPLAGSAGVLVPPEGYLKRNREICNQHNILLVFDEVITGF 265 Query: 287 G----LYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSV 342 G ++G GV + + + A P + ++ T F Sbjct: 266 GRTGSMFGADSFGVTPDLMCIAKQVTNGAIPMGAVIASTEIYQTFMNQPTPEYAVEFPH- 324 Query: 343 GGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGA---TAAIRYQRCHIDLRTSQQKHTM 399 GY ++ + A + L SV A A+ + K+ + Sbjct: 325 -GYTYSAHPVACAAGLAALCLLQKENLVQSVAEVAPHFEKALHGIKGA--------KNVI 375 Query: 400 YVKKAFHELGIPVIPNPSHIVPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTER 459 ++ I + P G+A + + + + K YV F G + Sbjct: 376 DIRNFGLAGAIQIAPRD--------GDAIVRPFEAGMALWKAGFYV---RF-----GGDT 419 Query: 460 LRITPTPGHTNDLSDILINAVDDVFNEL 487 L+ PT D L +AV +V N+L Sbjct: 420 LQFGPTFNSKPQDLDRLFDAVGEVLNKL 447 >5KQW-A nrPDB Length = 479 Score = 38.3 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 26/148 (17%), Positives = 46/148 (31%), Gaps = 16/148 (10%) Query: 218 HANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEK----ICDLADK 273 + + + ++L +L +L P +V I E V G + + I + +K Sbjct: 215 MSEAQFVRYCADELEKL--ILAEGPDTVAAFIG-EPVMGTGGIIPPPQGYWEAIQAVLNK 271 Query: 274 YGALTFLDE-VHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMIT 332 Y L DE V G G G + V ++V + Sbjct: 272 YDILLIADEVVCGFGRLGSK-MGSQHYGMKPDLITVAKGLTSAYAPLSGVIVGEKVWDVI 330 Query: 333 -------GTLGKSFGSVGGYVAASRKLI 353 G +G + G + A+ L Sbjct: 331 EKGSQEHGPMGHGWTYSGHPICAAAALA 358 >2CH1-A nrPDB Length = 396 Score = 38.3 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 26/200 (13%), Positives = 65/200 (32%), Gaps = 15/200 (7%) Query: 230 DLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVH---AV 286 L L + ++ + L + S +G + +E + + ++ L +D V V Sbjct: 131 SLETLARAIELHQPKCLFLTHGD---SSSGLLQPLEGVGQICHQHDCLLIVDAVASLCGV 187 Query: 287 GLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYV 346 Y A + + + + A V+ + +G Y Sbjct: 188 PFYMDKWEIDAVYTGAQKVLGAPPGITPISISPKALDVIRNRRTKSKVFYWDLLLLGNYW 247 Query: 347 AASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFH 406 + + + A IF L ++ A + + + + + + Sbjct: 248 GCYDEPKRYHHTVASNLIF--ALREALAQIAEEGLE------NQIKRRIECAQILYEGLG 299 Query: 407 ELGIPV-IPNPSHIVPVLIG 425 ++G+ + + +P H +P + G Sbjct: 300 KMGLDIFVKDPRHRLPTVTG 319 >6CJB-A nrPDB Length = 391 Score = 38.3 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 31/193 (16%), Positives = 65/193 (33%), Gaps = 5/193 (2%) Query: 161 LNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHAN 220 E +A+L + F+S A + V+ LLG + + + +K Sbjct: 64 KAYEDCIASLESGQKGFAFASGMAAINTVIDLLGSGDHVVAMDDLYGGTFRLFDKVK-TR 122 Query: 221 VKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFL 280 F D++ + + +++ KL+ E+ + +A++ KI +A KY +T Sbjct: 123 TSNLSFSFIDMS-VPENIEAAITPKTKLLWLETPSNPMLKLANLRKIAAIAKKYNLITVA 181 Query: 281 DEVHAVGLYG---PHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGK 337 D A G + H + G + D++ + + G Sbjct: 182 DNTFATPWIQRPLELGFDIVLHSATKYLNGHSDVVSGVVVVGDNSVLSDKIAFLQNSCGA 241 Query: 338 SFGSVGGYVAASR 350 G ++ Sbjct: 242 VAGPFDSFLVLRS 254 >4RIT-B nrPDB Length = 486 Score = 37.9 bits (86), Expect = 0.011, Method: Composition-based stats. Identities = 29/196 (14%), Positives = 58/196 (29%), Gaps = 31/196 (15%) Query: 106 AHRQREADKVTVWCSNDYLALSKHPE------VLDAMHKTIDKYGCGAGGTRNIAGHNIP 159 A D V +N+ L+L P +L + G AGG G Sbjct: 99 ATMAILGDLVAAAVNNNMLSLEMSPSFSRLETLLLRAIAGLFGLGEQAGGVLTSGGSLAN 158 Query: 160 TLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKH- 218 L A+ + + + + ++ L Q+ VIF+ E H S+ Sbjct: 159 LQAL------------AVARNVAFDSVEPGITGLAQRP---VIFASEAAHTSLQKAAMLL 203 Query: 219 --ANVKKHIFKHN-----DLNELEQLLQSYPKSVPKLIAFESVYSMAG--SVADIEKICD 269 + D +L + + + ++ + +I Sbjct: 204 GLGTAAVIPVRATADSRMDPEDLRARIDQARGAGQHPFCVVATAGTTTTGNIDPLAEIGA 263 Query: 270 LADKYGALTFLDEVHA 285 +A ++G +D + Sbjct: 264 IAREHGLWFHVDAAYG 279 >4ZWV-A nrPDB Length = 372 Score = 37.5 bits (85), Expect = 0.013, Method: Composition-based stats. Identities = 29/148 (19%), Positives = 49/148 (33%), Gaps = 19/148 (12%) Query: 161 LNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFS-----DELNHASMIVG 215 E+ LA + S L LL + + S + N A + G Sbjct: 36 AEFESALAARLGNPRVVSVHSGTSGLCLALRLLDAPEERDEVLSTPLTFEATNWAILADG 95 Query: 216 IKHANVKKHIFKHN-DLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLAD-K 273 + V DL++LE+ + P + ++ + Y + + I D A+ + Sbjct: 96 RRITWVDVDPATLTMDLDDLERKI--SPATRAIIVVHWTGYPVDLD--RLAGILDRAERE 151 Query: 274 YG--ALTFLDEVHAVGL------YGPHG 293 +G D HA G G HG Sbjct: 152 HGFRPAVIEDCAHAWGASYRGVPLGSHG 179 >3N5M-A nrPDB Length = 452 Score = 37.5 bits (85), Expect = 0.014, Method: Composition-based stats. Identities = 45/333 (13%), Positives = 107/333 (32%), Gaps = 63/333 (18%) Query: 153 IAGHNIPTLNLEAELATLHKKEGALVFS-SCYVANDAVLSLL-------GQKMKDLVIFS 204 ++ + P + L +L E + FS S AN+ + G+ + + Sbjct: 86 MSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETAFKIARQYYAQKGEPHRYKFMSR 145 Query: 205 DELNHASMIVGIKHANVKKHIFKHN--------------------------DLNELEQ-- 236 H + + + + +++ D+ +++ Sbjct: 146 YRGYHGNTMATMAATGQAQRRYQYEPFASGFLHVTPPDCYRMPGIERENIYDVECVKEVD 205 Query: 237 --LLQSYPKSVPKLIAFESVYSMAGSV-AD---IEKICDLADKYGALTFLDEVHAVGLYG 290 + +++ I E + + G + A ++ + + K+GAL DEV + +G Sbjct: 206 RVMTWELSETIAAFI-MEPIITGGGILMAPQDYMKAVHETCQKHGALLISDEV--ICGFG 262 Query: 291 PHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASR 350 G +A T+ + ++ ++F G Y Sbjct: 263 RTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKREIY-----EAFKGKGEY----- 312 Query: 351 KLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGI 410 ++FR I T P+ A A + + S Q ++ +++ E+G Sbjct: 313 ---EFFRH-----INTFGGNPAACALALKNLEIIENENLIERSAQMGSLLLEQLKEEIGE 364 Query: 411 PVIPNPSHIVPVLIGNADLAKQASDILINKHQI 443 + +L+G + + + I+ +I Sbjct: 365 HPLVGDIRGKGLLVGIELVNDKETKEPIDNDKI 397 >1CS1-A nrPDB Length = 386 Score = 37.1 bits (84), Expect = 0.019, Method: Composition-based stats. Identities = 30/135 (22%), Positives = 51/135 (37%), Gaps = 11/135 (8%) Query: 150 TRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIF--SDEL 207 +R ++ LA L GA++ ++ A +++ + K DL++ Sbjct: 47 SRRGNPTRDV---VQRALAELEGGAGAVLTNTGMSA-IHLVTTVFLKPGDLLVAPHDCYG 102 Query: 208 NHASMIVG-IKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEK 266 + K + D L L P KL+ ES + V DI K Sbjct: 103 GSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKP----KLVLVESPSNPLLRVVDIAK 158 Query: 267 ICDLADKYGALTFLD 281 IC LA + GA++ +D Sbjct: 159 ICHLAREVGAVSVVD 173 >5K8B-A nrPDB Length = 403 Score = 37.1 bits (84), Expect = 0.019, Method: Composition-based stats. Identities = 24/132 (18%), Positives = 48/132 (36%), Gaps = 11/132 (8%) Query: 160 TLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHA 219 T ++E L + A + SS A + + + + I A Sbjct: 39 TRDMEQLLCEKMNVKHAHLLSSGTAA-LQTAMMAAGIGAGDEVIVPPFTFVASVEAIFMA 97 Query: 220 NVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFES----VYSMAGSVADIEKICDLADKYG 275 IF E+++ L P+ + +I + + M GS+A +++I + K+ Sbjct: 98 GA-VPIFA-----EIDETLCLSPEGIEAVITPRTKAINLVHMCGSMAKMDEIKAICKKHN 151 Query: 276 ALTFLDEVHAVG 287 + D A+G Sbjct: 152 LVLLEDACQAIG 163 >1OHW-A nrPDB Length = 472 Score = 36.7 bits (83), Expect = 0.025, Method: Composition-based stats. Identities = 22/95 (23%), Positives = 35/95 (36%), Gaps = 7/95 (7%) Query: 230 DLNELEQLLQSYPKSVPKLIAFESVYSMAGSVAD----IEKICDLADKYGALTFLDEVHA 285 ++ +L + K+V +I E + S G K+ D++ K+G +DEV Sbjct: 244 EVEDLIVKYRKKKKTVAGIIV-EPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQT 302 Query: 286 VGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGG 320 G G G A A + K GG Sbjct: 303 GG--GSTGKFWAHEHWGLDDPADVMTFSKKMMTGG 335 >4BWG-A nrPDB Length = 347 Score = 36.7 bits (83), Expect = 0.027, Method: Composition-based stats. Identities = 25/118 (21%), Positives = 52/118 (44%), Gaps = 21/118 (17%) Query: 7 ARFGNSSAAVSTLNRLSTTAAPHAKNGYATATGAGAAAATATASSTHAAAAAAAAANHST 66 +RFGN+ ++ + T P AK G TG+G + ATA S AA + +T Sbjct: 240 SRFGNNWVDIAAPGQNITFLRPDAKTG----TGSGTSEATAIVSGVLAAMT--SCNPRAT 293 Query: 67 QESGFDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYL 124 +EL++ L+ + +Y + ++++ + ++++C +Y+ Sbjct: 294 -----------ATELKRTLLESADKYPSLVDKVTE----GRVLNAEKAISMFCKKNYI 336 >6ENZ-A nrPDB Length = 530 Score = 36.7 bits (83), Expect = 0.028, Method: Composition-based stats. Identities = 10/57 (17%), Positives = 27/57 (47%), Gaps = 2/57 (3%) Query: 231 LNELEQLL--QSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHA 285 +LE+ + +VP L+ S ++ G+ +++I ++ +++G +D Sbjct: 258 PEDLEKQIWQARQEGAVPFLVCATSGTTVLGAFDPLDEIAEVCERHGLWLHVDASWG 314 >3FDB-A nrPDB Length = 377 Score = 36.3 bits (82), Expect = 0.031, Method: Composition-based stats. Identities = 30/174 (17%), Positives = 58/174 (33%), Gaps = 37/174 (21%) Query: 130 PEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAV 189 P VL A+ + + G + L A + Y A Sbjct: 39 PAVLQAITDAVQREAFG---------YQPDGSLLSQATAEFYADRY------GYQARPEW 83 Query: 190 LSLLGQKMKDLVIFSDELNHAS---------------MIVGIKHANVKKHIFKHNDLNEL 234 + + ++ L I D A ++ + + +L+++ Sbjct: 84 IFPIPDVVRGLYIAIDHFTPAQSKVIVPTPAYPPFFHLLSATQREGIFIDATGGINLHDV 143 Query: 235 EQLLQSYPKSVPKLIAFESVYSMAG-SVAD--IEKICDLADKYGALTFLDEVHA 285 E+ Q+ + I + Y+ G A + ++CDLA +Y A +DE+HA Sbjct: 144 EKGFQA----GARSILLCNPYNPLGMVFAPEWLNELCDLAHRYDARVLVDEIHA 193 >5KR6-A nrPDB Length = 479 Score = 36.3 bits (82), Expect = 0.033, Method: Composition-based stats. Identities = 43/261 (16%), Positives = 80/261 (30%), Gaps = 39/261 (14%) Query: 123 YLALSKHP------EVLDAMH-KTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEG 175 Y+ S P ++ + K G G+ I + + +K+ Sbjct: 107 YVGHSNEPIIELSERIIREWAPAGMSKVYYGMSGSD-ANETQIKLVWYYNNVLGRPQKKK 165 Query: 176 ALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASM-IVGIKHAN-----------VKK 223 + Y + + L NH + + I+H + Sbjct: 166 IISRQRGYHGSGIMTGSLTGLPA-------FHNHFDLPLEPIRHTTCPHYYRAPAGMSEA 218 Query: 224 HIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEK----ICDLADKYGALTF 279 +H +ELE+++ + E V G V E I + +KY L Sbjct: 219 EFSRHC-ADELEKMILAEGPDTVAAFIGEPVMGTGGIVPPPEGYWEAIQAVLNKYDILLI 277 Query: 280 LDE-VHAVG----LYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKT--VMDRVDMIT 332 DE V G ++G H G+ + + P + G K V+++ Sbjct: 278 ADEVVCGFGRTGSMFGSHHYGMKPDLITVAKGLTSAYAPLSGVIVGEKVWKVLEQGSDQY 337 Query: 333 GTLGKSFGSVGGYVAASRKLI 353 G +G + G + A+ L Sbjct: 338 GPIGHGWTYSGHPICAAAALA 358 >2CB1-A nrPDB Length = 412 Score = 36.3 bits (82), Expect = 0.034, Method: Composition-based stats. Identities = 33/189 (17%), Positives = 65/189 (34%), Gaps = 8/189 (4%) Query: 134 DAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLL 193 + + +++ G G + LE L L A+V +S A A L L Sbjct: 33 KTLEEGQERFATGEGYV-YARQKDPTAKALEERLKALEGALEAVVLASGQAATFAALLAL 91 Query: 194 GQKMKDLVIFSDELNHASMIVGIKHA-NVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFE 252 + ++V + G + + + + + L + ++ + E Sbjct: 92 LRPGDEVVAAKGLFGQTIGLFGQVLSLMGVTVRYVDPEPEAVREALSAKTRA----VFVE 147 Query: 253 SVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIAT 312 +V + A V D+E + LA++ G +D G G +A + A+ Sbjct: 148 TVANPALLVPDLEALATLAEEAGVALVVDNT--FGAAGALCRPLAWGAHVVVESLTKWAS 205 Query: 313 PKTNDKGGA 321 + GGA Sbjct: 206 GHGSVLGGA 214 >1SFF-A nrPDB Length = 426 Score = 36.3 bits (82), Expect = 0.039, Method: Composition-based stats. Identities = 61/465 (13%), Positives = 132/465 (28%), Gaps = 97/465 (20%) Query: 78 DSELQKKRLDKSYRYFNNINRL--AKEFPLAHRQREADKVTVWCSN-DYLALSK-HPEVL 133 + EL ++R R I+ + + E + + L HP+V+ Sbjct: 4 NKELMQRRSQAIPRGVGQIHPIFADRAENCRVWDVEGREYLDFAGGIAVLNTGHLHPKVV 63 Query: 134 DAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVA--NDAVLS 191 A+ + K + + ++ K L+ ++ A N ++ Sbjct: 64 AAVEAQLKKLSHTCFQVLAYEPYLELCEIMNQKVPGDFAK-KTLLVTTGSEAVENAVKIA 122 Query: 192 LLGQKMKDLVIFSDEL---NHASMIV---------GIKHANVKKHIFKH----------N 229 K + FS H ++ + G+ + + + Sbjct: 123 RAATKRSGTIAFSGAYHGRTHYTLALTGKVNPYSAGMGLMPGHVYRALYPCPLHGISEDD 182 Query: 230 DLNELEQLL--QSYPKSVPKLIAFESVYSMAGSVAD----IEKICDLADKYGALTFLDEV 283 + + ++ + P+ + I E V G A ++++ L D++G + DEV Sbjct: 183 AIASIHRIFKNDAAPEDIAA-IVIEPVQGEGGFYASSPAFMQRLRALCDEHGIMLIADEV 241 Query: 284 HAVGLYGPHGAG----VAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSF 339 + GAG + V R +++ + Sbjct: 242 QS-------GAGRTGTLFAMEQMGVAPDLTTFAKSIAGGFPLAGVTGRAEVMDAV---AP 291 Query: 340 GSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRY------QRCHIDLRTS 393 G +GG A + P A ++ + DL Sbjct: 292 GGLGGTYAGN---------------------PIACVAALEVLKVFEQENLLQKANDLGQK 330 Query: 394 QQKHTMYVKKAFHELG----------IPVIPNPSHIVPVLIGNADLAKQASDILINKHQI 443 + + + + E+G I + + H P +A L + +K I Sbjct: 331 LKDGLLAIAEKHPEIGDVRGLGAMIAIELFEDGDHNKP----DAKLTAEIVARARDKGLI 386 Query: 444 YVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVDDVFNELQ 488 + + V LRI + + + F+E + Sbjct: 387 LLSCGPYYNV------LRILVPLTIEDAQIRQGLEIISQCFDEAK 425 >2GB3-A nrPDB Length = 409 Score = 35.9 bits (81), Expect = 0.040, Method: Composition-based stats. Identities = 49/349 (14%), Positives = 110/349 (31%), Gaps = 62/349 (17%) Query: 162 NLEAELATLHKK--------EGALVFSSCYVANDAVLSLLGQKMKDLVIFSDEL---NHA 210 L A+ +K+ E LV + A +++ ++++ N Sbjct: 83 ELREAFASYYKRRQRVDVKPENVLVTNGGSEAILFSFAVIANPGDEILVLEPFYANYNAF 142 Query: 211 SMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFES-------VYSMAGSVAD 263 + I G+K V + + + + Q L+S+ K I + VY + Sbjct: 143 AKIAGVKLIPVTRRM---EEGFAIPQNLESFINERTKGIVLSNPCNPTGVVYGKD----E 195 Query: 264 IEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKT 323 + + ++A+++G +DEV++ ++ G A + Sbjct: 196 MRYLVEIAERHGLFLIVDEVYSEIVF----RGEFAS---------------------ALS 230 Query: 324 VMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRY 383 + ++ ++ K F + G V + S A PP + + + Sbjct: 231 IESDKVVVIDSVSKKFSACGARVGCLITRNEELISHAMKLAQGRLAPPLLEQIGSVGLLN 290 Query: 384 QRCH--IDLRTSQQKHTMYVKKAFHELGIPVIPNPS------HIVPVLIGNADLAKQASD 435 +R + ++ V K E G+ PS +PV +D Sbjct: 291 LDDSFFDFVRETYRERVETVLKKLEEHGLKRFTKPSGAFYITAELPVEDAEEFARWMLTD 350 Query: 436 ILINKHQIYVQAIN----FPTVARGTERLRITPTPGHTNDLSDILINAV 480 ++ V + P + + R+ + D+L+ + Sbjct: 351 FNMDGETTMVAPLRGFYLTPGLGKKEIRIACVLEKDLLSRAIDVLMEGL 399 >4WBT-A nrPDB Length = 376 Score = 35.9 bits (81), Expect = 0.043, Method: Composition-based stats. Identities = 69/399 (17%), Positives = 130/399 (32%), Gaps = 66/399 (16%) Query: 104 PLAHRQREADKVTVWCSNDYLALSKHPEVLDAMHKTI---------DKYGCGAGGTRNIA 154 P A ++ K+ + P VL A+ + + + R++ Sbjct: 26 PEALERQHGRKIAARIGANESGFGPAPSVLLAIRQAAGDTWKYADPENHDLKQALARHL- 84 Query: 155 GHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIV 214 G + + + + L + LV A V++ LG + H Sbjct: 85 GTSPANIAIGEGIDGLLGQIVRLVV----EAGAPVVTSLGGYPTFNYHVA---GH----- 132 Query: 215 GIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADK- 273 G + + +D +LE LL + + L+ + + GS E++ A Sbjct: 133 GGRLV---TVPYA-DDREDLEGLLAAVGRENAPLVYLANPDNPMGSWWPAERVVAFAQAL 188 Query: 274 -YGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMIT 332 L LDE + P+ + + Sbjct: 189 PETTLLVLDEAY------------------------CETAPRDALPPIESLIDKPNVIRA 224 Query: 333 GTLGKSFGSVG---GYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHID 389 T K++G G GY ++ F F + +A A AA+ Q + Sbjct: 225 RTFSKAYGLAGARIGYTLSTPGTAQAFDKIRNHF----GMSRIGVAAAIAALADQDYLKE 280 Query: 390 LRTSQQKHTMYVKKAFHELGIPVIPNPSHIVPVLIG-NADLAKQASDILINKHQIYVQAI 448 + + + + G+ +P+ ++ V V G +A A+ D L++ H I+ I Sbjct: 281 VTLKIANSRQRIGRIAADSGLAPLPSATNFVAVDCGKDASYARAIVDRLMSDHGIF---I 337 Query: 449 NFPTVARGTERLRITPTPGHTNDLSDILINAVDDVFNEL 487 P VA +RI+ P + D+L A+ +V L Sbjct: 338 RMPGVAPLNRCIRISTAP---DAEMDLLAAALPEVIRSL 373 >4Q75-A nrPDB Length = 429 Score = 35.9 bits (81), Expect = 0.050, Method: Composition-based stats. Identities = 42/212 (19%), Positives = 72/212 (33%), Gaps = 20/212 (9%) Query: 95 NINRLAKEFPLAHRQREADKVTVWCSND----YL---ALSKHPE-VLDAMHKTIDKYGCG 146 I+ ++ L HR R+ ++ N YL A S+ P VLDA+ + Y Sbjct: 9 TISTDSESVSLGHRVRKDFRILHQEVNGSKLVYLDSAATSQKPAAVLDALQNYYEFYNSN 68 Query: 147 A-GGTRNIAG-HNIPTLNLEAELATLHKKEGA--LVFS-SCYVA-NDAVLS-LLGQKMKD 199 G ++ ++A + +VF+ + A N S L Sbjct: 69 VHRGIHYLSAKATDEFELARKKVARFINASDSREIVFTRNATEAINLVAYSWGLSNLKPG 128 Query: 200 LVIFSDELNHASM---IVGIKHANVKKHIFKHNDLNELEQL--LQSYPKSVPKLIAFESV 254 + H S + F + +E+ + L+ KL+A V Sbjct: 129 DEVILTVAEHHSCIVPWQIVSQKTGAVLKFVTLNEDEVPDINKLRELISPKTKLVAVHHV 188 Query: 255 YSMAGSVADIEKICDLADKYGALTFLDEVHAV 286 ++ S IE+I A GA +D +V Sbjct: 189 SNVLASSLPIEEIVVWAHDVGAKVLVDACQSV 220 >3LWS-A nrPDB Length = 357 Score = 35.6 bits (80), Expect = 0.059, Method: Composition-based stats. Identities = 46/296 (15%), Positives = 88/296 (29%), Gaps = 41/296 (13%) Query: 132 VLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLS 191 + A D+ GT I E + A + + A+ F S +A L Sbjct: 27 LKTAFAAVADEMASDQYGTGAII------EPFEQKFADVLGMDDAVFFPSGTMAQQVALR 80 Query: 192 LLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAF 251 I+SDE + + V H H +++E + L + +P + A Sbjct: 81 ----------IWSDETD---------NRTVAYHPLCHLEIHEQDGLKELHPIETILVGAA 121 Query: 252 ESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIA 311 + + ++ + + I L + A E + + Sbjct: 122 DRLMTLD-EIKALPDIACLLLELPQREIGGVAPAFSELETISRYCRERGIRLHLDGARLF 180 Query: 312 TPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLI-----DWFRSFAPGFIFT 366 + A + D I + K G + G + A W R + I Sbjct: 181 EMLPYYEKTAAEIAGLFDSIYISFYKGLGGIAGAILAGPAAFCQTARIWKRRYGGDLI-- 238 Query: 367 TTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIVPV 422 +L P +++ Y D + + + F+ L + + VPV Sbjct: 239 -SLYPYIVSADY----YYELRKDRMGQYYEQAKQLAEQFNALP---GVHTTPEVPV 286 >4KAM-A nrPDB Length = 453 Score = 35.6 bits (80), Expect = 0.060, Method: Composition-based stats. Identities = 43/319 (13%), Positives = 88/319 (27%), Gaps = 67/319 (21%) Query: 150 TRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNH 209 TR +E +A L AL SS A ++L I S + Sbjct: 72 TRLGNPTTDV---VEQRIAALEGGVAALFLSSGQAAE--TFAILNLAGAGDHIVSSPRLY 126 Query: 210 ASMIVGIKHANVK--KHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKI 267 ++ K + +D + L+ + + E++ + + D + Sbjct: 127 GGTYNLFHYSLAKLGIEVSFVDDPDNLDSWQAAVRPNTKAFFG-ETISNPQIDLLDTPGV 185 Query: 268 CDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDR 327 ++A + G +D + Sbjct: 186 AEVAHRNGIPLIVDN-------------------------------TIATPYLIRPFTQG 214 Query: 328 VDMITGTLGKSFGSVGGYVAA---SRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQ 384 D++ + K G G +A DW + P F TT PS A + Sbjct: 215 ADIVVHSATKYLGGHGAAIAGVIVDGGTFDWTQGRFPEF---TTPDPSYHGVVFAELGAP 271 Query: 385 RCHIDLRTSQQK---------HTMYVKKAFHELGIPVIPNPSHIVPVLIGNADLAKQASD 435 + R + + V + L + + + S A++ ++ Sbjct: 272 AYALKARVQLLRDLGSAASPFNAFLVAQGLETLSLRIERHVS-----------NAQRVAE 320 Query: 436 ILINKHQIYVQAINFPTVA 454 L ++ V +N+ + Sbjct: 321 FLADRED--VVTVNYAGLP 337 >2C81-A nrPDB Length = 418 Score = 35.2 bits (79), Expect = 0.078, Method: Composition-based stats. Identities = 24/146 (16%), Positives = 49/146 (33%), Gaps = 4/146 (2%) Query: 150 TRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNH 209 + G A + + +S A L LG D VI Sbjct: 34 SGYWTGEESMERKFAKAFADFNGVPYCVPTTSGSTALMLALEALGIGEGDEVIVPSLTWI 93 Query: 210 ASMIVGIKHANVKKHIFKHNDLNELE-QLLQSYPKSVPKLIAFESVYSMAGSVADIEKIC 268 A+ + + + D ++ QL++S K I ++ GS+A++++I Sbjct: 94 ATATAVLNVNALPVFVDVEADTYCIDPQLIKSAITDKTKAIIPVHLF---GSMANMDEIN 150 Query: 269 DLADKYGALTFLDEVHAVGLYGPHGA 294 ++A ++ D + G + Sbjct: 151 EIAQEHNLFVIEDCAQSHGSVWNNQR 176 >1T3I-A nrPDB Length = 420 Score = 35.2 bits (79), Expect = 0.080, Method: Composition-based stats. Identities = 26/139 (18%), Positives = 46/139 (33%), Gaps = 18/139 (12%) Query: 157 NIPTLNLEAELATLHKK--EGALVFS-SCYVA-NDAVLS-LLGQKMKDLVIFSDELNHAS 211 + ++A +V++ + A N S + I + + H S Sbjct: 71 TDAYEAVRNKVAKFINARSPREIVYTRNATEAINLVAYSWGMNNLKAGDEIITTVMEHHS 130 Query: 212 MIV---------GIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVA 262 +V G V+ + DL + LL KL+ + + G V Sbjct: 131 NLVPWQMVAAKTGAVLKFVQLDEQESFDLEHFKTLLS----EKTKLVTVVHISNTLGCVN 186 Query: 263 DIEKICDLADKYGALTFLD 281 E+I LA + GA +D Sbjct: 187 PAEEIAQLAHQAGAKVLVD 205 >2JIS-A nrPDB Length = 515 Score = 34.8 bits (78), Expect = 0.089, Method: Composition-based stats. Identities = 17/102 (16%), Positives = 38/102 (37%), Gaps = 10/102 (9%) Query: 198 KDLVIFSDELNHASMIVGIK---HANVKKHIFKHND-----LNELEQLLQSYPKSV--PK 247 L +F+ + H S+ G + K ++ +LE+ + P Sbjct: 202 PPLALFTSKECHYSIQKGAAFLGLGTDSVRVVKADERGKMVPEDLERQIGMAEAEGAVPF 261 Query: 248 LIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLY 289 L++ S ++ G+ +E I D+ ++G +D + Sbjct: 262 LVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAAWGGSVL 303 >5KQT-A nrPDB Length = 479 Score = 34.8 bits (78), Expect = 0.093, Method: Composition-based stats. Identities = 42/215 (19%), Positives = 67/215 (31%), Gaps = 44/215 (20%) Query: 227 KHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEK----ICDLADKYGALTFLDE 282 +H +L P +V I E V G + + I + KY L DE Sbjct: 222 RHCAQELENLILAEGPDTVAAFIG-EPVMGTGGIIVPPKGYWEAIQAVLAKYDVLLIADE 280 Query: 283 -VHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGT--LGKSF 339 V A G G DK G++ R D+IT L ++ Sbjct: 281 VVCAFGRLG--------------------------DKMGSQRHAMRPDLITTAKGLTSAY 314 Query: 340 GSVGGYVAASR--KLIDWF--RSFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQ 395 + + + +ID R A G +T + P A A A + R + Sbjct: 315 APLSAVIVGEKVWDVIDSASTREGAMGHGWTYSGHPICAAAALANLDILE-----RENIT 369 Query: 396 KHTMYVKKAFHELGIPVIPNPSHIVPVLIGNADLA 430 + V + + +V + G+ LA Sbjct: 370 ANAADV-GGYLNQQLRQAFEGHPLVGEVRGDGMLA 403 >2YRI-A nrPDB Length = 353 Score = 34.8 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 45/244 (18%), Positives = 78/244 (31%), Gaps = 29/244 (11%) Query: 230 DLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLY 289 D + + L+ + L+ E+ G + E I LA + GAL FLD V +G+ Sbjct: 112 DPEAVARALKRRRYRMVALVHGET---STGVLNPAEAIGALAKEAGALFFLDAVTTLGML 168 Query: 290 GPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAAS 349 + F + A P + K+F G+ Sbjct: 169 PFSMRAMGVDYAFTGSQKCLSAPPGLAPIAASLEAR-----------KAFTGKRGWYLDL 217 Query: 350 RKLID-WFRSFAPGFIFTTTLPPSVMA-GATAAIRYQRCHIDLRTSQQKHTMY--VKKAF 405 ++ + W R G+ TT P ++ A+ ++ +Y V + Sbjct: 218 ARVAEHWERG---GYHHTT---PVLLHYALLEALDLVLEEGVAARERRAREVYAWVLEEL 271 Query: 406 HELGIPVIPNPSHIVPVLIGNADLAKQASDIL--INKHQIYVQAINFPTVARGTERLRIT 463 G P S + VL+ A ++ + + V PT RG LR+ Sbjct: 272 KARGFRPYPKASPLPTVLVVRPPEGVDADRLVRALYAEGVAVAGGIGPT--RGQ-VLRLG 328 Query: 464 PTPG 467 Sbjct: 329 LMGE 332 >5TSU-A nrPDB Length = 422 Score = 34.4 bits (77), Expect = 0.12, Method: Composition-based stats. Identities = 27/155 (17%), Positives = 56/155 (36%), Gaps = 20/155 (12%) Query: 135 AMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLG 194 + G +R+ LE +A L + L F+S A ++ L Sbjct: 63 TFKQGAPGQHSGFNYSRSGNPTRNC---LEKAVAALDGAKYCLAFASGLAATV-TITHLL 118 Query: 195 QKMKDLVIFSDELNHASMI-------VGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPK 247 + ++ D ++ G+K + V D +++ +LL++ K Sbjct: 119 KAGDQIICMDDVYGGTNLYFRQVASEFGLKISFV--------DCSKI-KLLEAAITPETK 169 Query: 248 LIAFESVYSMAGSVADIEKICDLADKYGALTFLDE 282 L+ E+ + V DIE + K+G + + + Sbjct: 170 LVWIETPTNPTQKVIDIEGCAHIVHKHGDIILVVD 204 >6HNV-A nrPDB Length = 524 Score = 34.4 bits (77), Expect = 0.12, Method: Composition-based stats. Identities = 20/104 (19%), Positives = 36/104 (34%), Gaps = 9/104 (8%) Query: 265 EKICDLADKYGALTFLDEVHAVGLY----GPH--GAGVAEHCDFESHRASGIATPKTNDK 318 +KI DLA KY D+ + P+ G+G + Sbjct: 264 KKIYDLAVKYDFAIIEDDPYGYLTLPKYEKPNIGGSGSGNNELKNDLEIDDYLKNHLTPS 323 Query: 319 GGAKTVMDRVDMITGTLGKSF--GSVGGYVAASRKLIDWFRSFA 360 RV + T K F G G++ +++ID ++++ Sbjct: 324 YLELDTTGRV-LRVETFSKLFAPGLRLGFIVGHKEVIDAVKNYS 366 >1I43-A nrPDB Length = 445 Score = 34.4 bits (77), Expect = 0.13, Method: Composition-based stats. Identities = 27/134 (20%), Positives = 47/134 (35%), Gaps = 10/134 (7%) Query: 151 RNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHA 210 R + LE +++ L E L+ +S A+ +L L +V +D Sbjct: 110 RYGNPTTVV---LEEKISALEGAESTLLMASGMCASTVMLLALVPAGGHIVTTTDCYRKT 166 Query: 211 SMIVGI---KHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKI 267 + + K I D ++ L + + L ES + DIE + Sbjct: 167 RIFIETILPKMGITATVI----DPADVGALELALNQKKVNLFFTESPTNPFLRCVDIELV 222 Query: 268 CDLADKYGALTFLD 281 L + GAL +D Sbjct: 223 SKLCHEKGALVCID 236 >1IJI-A nrPDB Length = 356 Score = 34.4 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 14/79 (17%), Positives = 29/79 (36%), Gaps = 5/79 (6%) Query: 334 TLGKSFGSVG---GYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDL 390 TL K+F G G+ A+ ++I+ + +T P + +A + + + Sbjct: 211 TLSKAFALAGLRCGFTLANEEVINLLMKVIAPYPLST--PVADIAAQALSPQGIVAMRER 268 Query: 391 RTSQQKHTMYVKKAFHELG 409 Y+ A E+ Sbjct: 269 VAQIIAEREYLIAALKEIP 287 >6B9O-A nrPDB Length = 981 Score = 34.0 bits (76), Expect = 0.17, Method: Composition-based stats. Identities = 18/52 (34%), Positives = 24/52 (46%), Gaps = 1/52 (1%) Query: 22 LSTTAAPHAKNGYATATGAGAAAATATASSTHAAAAAAAAANH-STQESGFD 72 +S TA H N YA GA+ A A SS+ A + +A+ S S F Sbjct: 389 VSGTAKQHTTNDYAKRLAIGASKAEAVVSSSLACLTSKQSADQCSAPASAFS 440 >3QI6-A nrPDB Length = 392 Score = 33.3 bits (74), Expect = 0.26, Method: Composition-based stats. Identities = 25/105 (23%), Positives = 40/105 (38%), Gaps = 6/105 (5%) Query: 179 FSSCYVANDAVLSLLGQKMKDLVIFSDELNHA-SMIVGIKHA-NVKKHIFKHNDLNELEQ 236 FSS A D L + + +VI D +I + NV+ DL+ + Sbjct: 87 FSSGMAAADCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTGWNVEYTPVALADLDAVRA 146 Query: 237 LLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLD 281 ++ +LI E+ + S+ADI I L A +D Sbjct: 147 AIR----PTTRLIWVETPTNPLLSIADIAGIAQLGADSSAKVLVD 187 >2GMS-A nrPDB Length = 390 Score = 33.3 bits (74), Expect = 0.28, Method: Composition-based stats. Identities = 43/269 (15%), Positives = 88/269 (32%), Gaps = 33/269 (12%) Query: 161 LNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHAN 220 E + A + A++ SS AN +++ L K + DE+ ++ + + Sbjct: 37 KQYETQFAKTFGSKYAVMVSSGSTANLLMIAALFFTKKPRLKKGDEI----IVPAVSWST 92 Query: 221 --------VKKHIFKHNDLNELE---QLLQSYPKSVPKLIAFESVYSMAGSVADIEKICD 269 + F D+N L + L+ K I ++ G+ + ++I Sbjct: 93 TYYPLQQYGLRVKFVDIDINTLNIDIESLKEAVTDSTKAILT---VNLLGNPNNFDEINK 149 Query: 270 LADKYGALTFLDEVHAVG-LYGPHGAGVAEHCDFESH-------RASGIATPKTNDKGGA 321 + + D ++G + AG S G +++ Sbjct: 150 IIGGRDIILLEDNCESMGATFNNKCAGTFGLMGTFSSFYSHHIATMEGGCIVTDDEEIYH 209 Query: 322 KTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAI 381 + R T L K G V + + + F+ PG+ + P M+GA I Sbjct: 210 ILLCIRAHGWTRNLPKKNKVTG--VKSDDQFEESFKFVLPGY----NVRPLEMSGAI-GI 262 Query: 382 RYQRCHIDLRTSQQKHTMYVKKAFHELGI 410 + + ++K+ Y F + Sbjct: 263 EQLKKLPRFISVRRKNAEYFLDKFKDHPY 291 >3G7Q-A nrPDB Length = 417 Score = 33.3 bits (74), Expect = 0.29, Method: Composition-based stats. Identities = 30/271 (11%), Positives = 79/271 (29%), Gaps = 39/271 (14%) Query: 165 AELATLHKKEGALVFS----SCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIK--- 217 +A + + A + + A+ + +L + + ++D + V + Sbjct: 99 QNIALTNGSQSAFFYLFNLFAGRRADGSTKKVLFPLAPEYIGYADSGLEDDLFVSARPNI 158 Query: 218 -HANVKKHIFKHNDLNEL------EQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDL 270 + + H D L + S P + + + ++ K+ L Sbjct: 159 ELLPEGQFKY-HVDFEHLHIGEETGMICVSRPTNPTGNVITDE---------ELMKLDRL 208 Query: 271 ADKYGALTFLDEVHAV---GLYGPHGAGV--AEHCDFESHRASGIATPKTNDKGGAKTVM 325 A+++ +D + V G+ + S G+ + + Sbjct: 209 ANQHNIPLVIDNAYGVPFPGIIFSEARPLWNPNIILCMSLSKLGLPGSRCGIIIANDKTI 268 Query: 326 DRVDMITGTLGKSFGSVGGYVAA----SRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAI 381 + + G + + G +G + L+ + F + + A I Sbjct: 269 TAIANMNGIISLAPGGMGPAMMCEMIKRNDLLRLSETVIKPFYYQR------VQQTIAII 322 Query: 382 RYQRCHIDLRTSQQKHTMYVKKAFHELGIPV 412 R + + +++ F +L I Sbjct: 323 RRYLSEERCLIHKPEGAIFLWLWFKDLPITT 353 >3NNK-A nrPDB Length = 411 Score = 33.3 bits (74), Expect = 0.30, Method: Composition-based stats. Identities = 13/104 (12%), Positives = 41/104 (39%), Gaps = 9/104 (8%) Query: 189 VLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIF--KHNDL---NELEQLLQSYPK 243 ++S + K LV H + + + H ++ +++E ++ Sbjct: 81 LVSAIRPGDKVLVPVFGRFGHL-LCEIARRCRAEVHTIEVPWGEVFTPDQVEDAVKRIRP 139 Query: 244 SVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVG 287 + + ++ +M + + ++ ++ +Y AL + D ++G Sbjct: 140 RLLLTVQGDTSTTM---LQPLAELGEICRRYDALFYTDATASLG 180 >6CCZ-A nrPDB Length = 455 Score = 32.9 bits (73), Expect = 0.38, Method: Composition-based stats. Identities = 63/393 (16%), Positives = 117/393 (29%), Gaps = 83/393 (21%) Query: 142 KYGCGAGGTRNIAGHNIPTLNLE-----AELATLHKKEGALVFS----SCYVANDAVLSL 192 KY G G R G+ LE LA H + S AN AV + Sbjct: 55 KYSEGLPGKRYYGGNEHID-ELEILCQQRALAAFHLDGDKWGVNVQPLSGSPANFAVYTA 113 Query: 193 LGQKMKD----LVIFSDELNHASMIVGIKHANVKKH----IFKHND---LNELEQLLQSY 241 + + + L+H M + + + ++ ++ + + + L ++ Sbjct: 114 ILKPHDRIMGLDLPHGGHLSHGFMTAKRRVSGTSIYFESMPYRLDESTGVIDYDMLEKTA 173 Query: 242 PKSVPKLIAF-ESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHC 300 PKLI S Y A + +AD GA +D H GL Sbjct: 174 ALFRPKLIIAGASAYPRDIDYA---RFRKIADSVGAFLMMDMAHVSGLI----------- 219 Query: 301 DFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSF-GSVGGYVAASRKLIDWFRSF 359 + VD++T T KS G GG + + + Sbjct: 220 ----------------AASVLADPFEFVDIVTTTTHKSLRGPRGGMIFFKKDAVHGVDLE 263 Query: 360 APGFIFTTTLPPSV--------MAGATAAIRYQRCHI--DLRTSQQKHTMYVKKAFHELG 409 + + P + + G ++Y + + + + + E Sbjct: 264 SA---INNAVFPGLQGGPHNHTIGGLAVCLKYAQSPDFKNYQNQVVANCRALANRLVEHE 320 Query: 410 IPVIPNPS--HIVPVLIGNADLAKQASDILINKHQIY-----VQAINFPTVARGTERLRI 462 ++ S H+V V + + + + +++ I V V G +RI Sbjct: 321 YKLVSGGSDNHLVLVDLRPSGIDGARVEKILDMASITLNKNSVPGDKSALVPGG---IRI 377 Query: 463 TPTPGHT-------NDLSDILINAVDDVFNELQ 488 T +L LI+ + E + Sbjct: 378 GSPAMTTRGLGEKEFELIADLIHEGVRISLEAK 410 >5WGB-A nrPDB Length = 426 Score = 32.5 bits (72), Expect = 0.46, Method: Composition-based stats. Identities = 36/237 (15%), Positives = 70/237 (29%), Gaps = 54/237 (22%) Query: 129 HPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPT----------LNLEAELATLHKK-EGAL 177 P VLDAM + Y H+ ++A+L + Sbjct: 39 DPRVLDAMLPYLINY--------YGNPHSRTHAYGWESEAAMERARQQVASLIGADPREI 90 Query: 178 VFSSC-YVANDAVLSLLGQ--KMKDLVIFSDELNHASMIVGIKHANVK--------KHIF 226 +F+S +N+ + + + + + + + + H ++ + + Sbjct: 91 IFTSGATESNNIAIKGVARFYRSRKKHLITTQTEHKCVLDSCRSLEAEGFQVTYLPVQKS 150 Query: 227 KHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAV 286 DL ELE +Q L++ +V + G I +I + D AV Sbjct: 151 GIIDLKELEAAIQ----PDTSLVSVMTVNNEIGVKQPIAEIGRICSSRKVYFHTDAAQAV 206 Query: 287 G--------------------LYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKT 323 G +YGP G G R + + ++G Sbjct: 207 GKIPLDVNDMKIDLMSISGHKIYGPKGVGAIYIRRRPRVRVEALQSGGGQERGMRSG 263 >4K2M-A nrPDB Length = 443 Score = 32.1 bits (71), Expect = 0.58, Method: Composition-based stats. Identities = 23/132 (17%), Positives = 46/132 (34%), Gaps = 10/132 (7%) Query: 161 LNLEAELATLHKKEGALVFSSCYVAND-AVLSLLGQKMKDLVIFSDELNHASMIVGIKHA 219 E L+T K + SS A +L+L ++++ ++ S A Sbjct: 106 EQFEKVLSTYLHKRYVIATSSGTDAIMIGLLALGLNPGDEVIMPANSF---SATENAVLA 162 Query: 220 NVKKHIFKHNDLNEL---EQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGA 276 + I+ + ++ K I +Y G +D++ I +A++Y Sbjct: 163 SGGVPIYVDINPQTFCIDPDKIEEAITPYTKFILPVHLY---GKHSDMQHIRQIANRYKL 219 Query: 277 LTFLDEVHAVGL 288 D +GL Sbjct: 220 KVIEDACQGIGL 231 >2XYY-A nrPDB Length = 430 Score = 32.1 bits (71), Expect = 0.59, Method: Composition-based stats. Identities = 10/42 (23%), Positives = 19/42 (45%) Query: 249 IAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYG 290 + +++ G ++ + +C +A YG E VGL G Sbjct: 386 VGLNGIFATQGDISTLSGLCRIALWYGVNATRPEAIGVGLPG 427 >5EJ2-A nrPDB Length = 308 Score = 31.7 bits (70), Expect = 0.81, Method: Composition-based stats. Identities = 41/243 (16%), Positives = 76/243 (31%), Gaps = 35/243 (14%) Query: 226 FKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLAD----KYGALTFLD 281 + H+ +L + K + + I V V D E + D + G L + Sbjct: 78 YPHSTPEDLAET-ADLVKDLDRRIVTAQV-----DVRDFEALKSAVDSGVEQLGRLDIIV 131 Query: 282 EVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGA---KTVMDRVDMITGTLG-- 336 VG G + ++ + + T G ++T ++G Sbjct: 132 ANAGVGTDGRKLHKIRDNVWQDMIDINLTGVWHTVKAGVPHVLSGGRGGSIVLTSSVGGR 191 Query: 337 KSFGSVGGYVAASRKLIDWFRSFA----PGFIFTTTLPPSVMAGATAAIRYQRCHIDLRT 392 K++ + G Y+AA +I R+FA P I + P+ ++ Sbjct: 192 KAYPNTGHYIAAKHGVIGLMRAFAVELGPHMIRVNAVLPTQVSTTMVM------------ 239 Query: 393 SQQKHTMYVKKAFHELG---IPVIPNPSHIVPVLIGNADLAKQASDILINKHQIYVQAIN 449 + + G I H +PV +A A L + YV ++ Sbjct: 240 -NDQTFRLFRPDLENPGPDDFAPISQMMHTLPVPWVDASDISNAVLFLASDESRYVTGVS 298 Query: 450 FPT 452 P Sbjct: 299 LPV 301 >5DX5-A nrPDB Length = 400 Score = 31.3 bits (69), Expect = 1.0, Method: Composition-based stats. Identities = 31/162 (19%), Positives = 61/162 (37%), Gaps = 24/162 (14%) Query: 132 VLDAMHKTIDKYGCGAGG---TRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDA 188 + D+ + ++ G +R + +E +LA L E A+V +S A A Sbjct: 38 IFDSAEQGGRRFAGEESGYIYSRLGNPTST---EVENKLALLEGGEAAVVAASGMGAIAA 94 Query: 189 VLSLLGQKMK----DLVIFSDE---LNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSY 241 L + ++ LNH G++ V ++L+E++ L+ Sbjct: 95 SLWSALKSGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDV-----SNLDEVKNALK-- 147 Query: 242 PKSVPKLIAFESVYSMAGSVADIEKICDLADKYG--ALTFLD 281 K++ E+ + V DI KI ++ + F+D Sbjct: 148 --PNTKVVYLETPANPTLKVTDIRKISNMVHESNKECFVFVD 187 >2YWJ-A nrPDB Length = 186 Score = 31.3 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 17/58 (29%), Positives = 26/58 (44%), Gaps = 2/58 (3%) Query: 77 IDSELQKKRLDKSYRYFNNINRLAKEF--PLAHRQREADKVTVWCSNDYLALSKHPEV 132 + E++ K L K Y F + K + R+ DK+ Y+ALS HPE+ Sbjct: 111 FEKEIEFKDLGKVYGVFIRAPVVDKILSDDVEVIARDGDKIVGVKQGKYMALSFHPEL 168 >3GR7-A nrPDB Length = 340 Score = 30.9 bits (68), Expect = 1.3, Method: Composition-based stats. Identities = 12/75 (16%), Positives = 28/75 (37%), Gaps = 5/75 (6%) Query: 214 VGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFE---SVYSMAGSVADIEKICDL 270 G K H + + ++ ++ P+ E ++S +A + ++ L Sbjct: 34 DGAVRTWHKIH-YPARAVGQVGLIIVEATGVTPQGRISERDLGIWS-DDHIAGLRELVGL 91 Query: 271 ADKYGALTFLDEVHA 285 ++GA + HA Sbjct: 92 VKEHGAAIGIQLAHA 106 >3BXZ-A nrPDB Length = 471 Score = 30.9 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 17/35 (48%) Query: 168 ATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVI 202 A H E A+V + Y A + + + + D+V+ Sbjct: 343 AKFHANEAAIVAQAGYPAAVTIATNMAGRGTDIVL 377 >2FSI-A nrPDB Length = 853 Score = 30.9 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 17/35 (48%) Query: 168 ATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVI 202 A H E A+V + Y A + + + + D+V+ Sbjct: 473 AKFHANEAAIVAQAGYPAAVTIATNMAGRGTDIVL 507 >5K9T-A nrPDB Length = 578 Score = 30.9 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 17/35 (48%) Query: 168 ATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVI 202 A H E A+V + Y A + + + + D+V+ Sbjct: 469 AKFHANEAAIVAQAGYPAAVTIATNMAGRGTDIVL 503 >3ZRR-A nrPDB Length = 384 Score = 30.6 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 31/178 (17%), Positives = 56/178 (31%), Gaps = 11/178 (6%) Query: 239 QSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAE 298 + KS KL+A V + G ++ + + KY L +D V +V G E Sbjct: 121 EEVRKSEYKLVALTHVETSTGVREPVKDVINKIRKYVELIVVDGVSSV--------GAEE 172 Query: 299 HCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRS 358 E + + + A + + ++ S S+ GY R + R Sbjct: 173 VKAEEWNVDVYLTASQKALGSAAGLGLLLLSPKALSILDSQNSIAGYYLDLRNWLPVMRG 232 Query: 359 FAPGFIFTTTLPPS-VMAGATAAIRYQRCHI--DLRTSQQKHTMYVKKAFHELGIPVI 413 G PP V+ A R + ++ LG+ ++ Sbjct: 233 AEEGKAAYFATPPVHVILQLAEAFRLIEKEGIENRIKRHTMVASAIRAGLEALGLEIV 290 >3GC2-A nrPDB Length = 323 Score = 30.6 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 23/122 (18%), Positives = 47/122 (38%), Gaps = 15/122 (12%) Query: 402 KKAFHELGIPVIPNPSHIVPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLR 461 + E GI + + S + AD +A + + I PT+ +++R Sbjct: 203 RAFARETGIAIAWDES------LREADFTFEA------EEGVRAVVIK-PTLTGSLDKVR 249 Query: 462 ITPTPGHTNDLSDILINAVDDVFNELQLPRVRDWESQGGLLGVGESGFVEESNL--WTSS 519 H L+ ++ ++++ QL R+ W + G L G+ ++ + W S Sbjct: 250 EQVAAAHALGLTAVISSSIESSLGLTQLARIAAWLTPGTLPGLDTLHLMQAQQIRPWPGS 309 Query: 520 QL 521 L Sbjct: 310 AL 311 >1CSR-A nrPDB Length = 435 Score = 30.2 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 35/182 (19%), Positives = 67/182 (36%), Gaps = 9/182 (4%) Query: 365 FTTTLPPSVMAGATAAIRYQRCHIDLRTSQQK--HTMYVKKAFHELGIPVIPNPSHIVPV 422 F T L P + +AAI + + + + + +E + +I + Sbjct: 129 FPTNLHPM--SQLSAAITALNSESNFARAYAEGINRTKYWEFVYEDAMDLIAKLPCVAAK 186 Query: 423 LIGN---ADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINA 479 + N A + A D ++ + + + T + TE +R+ T ++ ++ + Sbjct: 187 IYRNLYRAGSSIGAIDSKLDWSHNFTNMLGY-TDPQFTELMRLYLTIHSDHEGGNVSAHT 245 Query: 480 VDDVFNELQLPRVRDWESQGGLLGVGESGFVEESNLWTSS-QLSLTNDDLNPNVRDPIVK 538 V + L P + + GL G +E LW S Q L D + +RD I Sbjct: 246 SHLVGSALSDPYLSFAAAMNGLAGPLHGLANQEVLLWLSQLQKDLGADASDEKLRDYIWN 305 Query: 539 QL 540 L Sbjct: 306 TL 307 >4L0O-H nrPDB Length = 388 Score = 29.8 bits (65), Expect = 3.2, Method: Composition-based stats. Identities = 28/142 (19%), Positives = 50/142 (35%), Gaps = 10/142 (7%) Query: 150 TRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNH 209 +R+ LE +A L F+S AV SLL L+ Sbjct: 45 SRSGNPTRF---ALEELIADLEGGVKGFAFASGLAGIHAVFSLLQSGDHVLLGDDVYGGT 101 Query: 210 ASMIVGI--KHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKI 267 + + K+ I D +++ Q ++ K K + E+ + + D+ + Sbjct: 102 FRLFNQVLVKNGLSCTII----DTSDISQ-IKKAIKPNTKALYLETPSNPLLKITDLAQC 156 Query: 268 CDLADKYGALTFLDEVHAVGLY 289 +A +G LT +D A Y Sbjct: 157 ASVAKDHGLLTIVDNTFATPYY 178 >4FHA-A nrPDB Length = 311 Score = 29.8 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 14/64 (21%), Positives = 22/64 (34%), Gaps = 1/64 (1%) Query: 70 GFDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSKH 129 GF I K + Y++F I A + P+ V L L+ H Sbjct: 103 GFAAGLAIVPYYNKPSQEGMYQHFKAIA-DASDLPIIIYNIPGRVVVELTPETMLRLADH 161 Query: 130 PEVL 133 P ++ Sbjct: 162 PNII 165 >3CAI-A nrPDB Length = 406 Score = 29.8 bits (65), Expect = 3.5, Method: Composition-based stats. Identities = 12/45 (26%), Positives = 18/45 (40%) Query: 239 QSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEV 283 +S +L+A S G V D+ + L GAL +D Sbjct: 159 ESLISKSTRLVAVNSASGTLGGVTDLRAMTKLVHDVGALVVVDHS 203 >4EAR-A nrPDB Length = 324 Score = 29.4 bits (64), Expect = 3.8, Method: Composition-based stats. Identities = 13/49 (26%), Positives = 22/49 (44%), Gaps = 1/49 (2%) Query: 122 DYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGH-NIPTLNLEAELAT 169 D + +S PEV+ A H + +G + I + ++ N E LA Sbjct: 250 DAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANWEEVLAA 298 >3HNO-A nrPDB Length = 419 Score = 29.4 bits (64), Expect = 4.3, Method: Composition-based stats. Identities = 30/148 (20%), Positives = 57/148 (38%), Gaps = 12/148 (8%) Query: 210 ASMIVGIKHANVKK-HIFKHND--LNEL-EQLLQSYPKSVPKLIAFESVYSMAGSVAD-- 263 A +I + + K I+ + + L E L+ + +S + A Y+ +G+ Sbjct: 23 AGVIEAARKQSGKIGRIYAGRNGIIGALTEDLIDTGQESDAAISALR--YTPSGAFGSCR 80 Query: 264 --IEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGA 321 ++ + +Y L + + H +G + +G G + + + SG Sbjct: 81 YKLKSLEQNRREYERLIEVFKAHDIGYFFYNGGGDSADTCLKVSQLSGTLGYPIQAIHVP 140 Query: 322 KTVMDRVDMITGTLGKSFGSVGGYVAAS 349 KTV D+ FGSV Y+A S Sbjct: 141 KTV--DNDLPITDCCPGFGSVAKYIAVS 166 >3IUU-A nrPDB Length = 495 Score = 29.4 bits (64), Expect = 4.4, Method: Composition-based stats. Identities = 31/242 (12%), Positives = 73/242 (30%), Gaps = 25/242 (10%) Query: 311 ATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLP 370 P+ + +G L + G+ A ++D F+ Sbjct: 185 RPPRAIYSLIPFLTRGNDETWSGPLAE-IGAAADRWRARSDVVDLSIFNVHPFLDVPGYG 243 Query: 371 PSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELG------------IPVIPNPSH 418 V+A + DL K ++ + + + Sbjct: 244 QVVLAYDNGSGAAIDACRDLSDMLWKARDEFQEQLMSVDKALEIARTSRQLLALGDQGDR 303 Query: 419 IVPVLIGNADLAKQASDILINKHQIYVQAINFPTV-----ARGTERLRITPTPGHTNDLS 473 ++ G++ + + ++ V + V A +R+ T+ Sbjct: 304 VMGAGPGDSPEIARVALEHFPGLKVAVPVYDPQAVRTAREAGENATVRMAVGGAFTHS-- 361 Query: 474 DILINAVDDVFNELQLPRVRDWESQGGLLGVGESGFVEESNLWTSSQLSLTNDDLNPNVR 533 + ++ + +L R R + + G + E+ F + + L T +++ + PNV Sbjct: 362 ---VAPLERDWTVRKLCRAR-FTNIGPYMAGTEADFGDAAVL-TCDAVTVIVTTMAPNVH 416 Query: 534 DP 535 DP Sbjct: 417 DP 418 >2OC4-A nrPDB Length = 289 Score = 28.6 bits (62), Expect = 6.9, Method: Composition-based stats. Identities = 13/49 (26%), Positives = 22/49 (44%), Gaps = 1/49 (2%) Query: 122 DYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGH-NIPTLNLEAELAT 169 D + +S PEV+ A H + +G + I + ++ N E LA Sbjct: 215 DAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANDEEVLAA 263 >6A2F-A nrPDB Length = 358 Score = 28.6 bits (62), Expect = 8.0, Method: Composition-based stats. Identities = 12/71 (16%), Positives = 20/71 (28%), Gaps = 4/71 (5%) Query: 126 LSKHPEVLDAMHKTIDKYGCGAGG---TRNIAGHNIPTLNLEAELATLHKKEGALVFSSC 182 L P L A H + + + E +L + L F Sbjct: 131 LGFDPAALRAWHARLRSHPGVRELNLISHFACADERNHPLTEQQLESFLGLLD-LDFDQR 189 Query: 183 YVANDAVLSLL 193 +AN A + + Sbjct: 190 SLANSAAVLTI 200 >4JN6-A nrPDB Length = 346 Score = 28.6 bits (62), Expect = 8.0, Method: Composition-based stats. Identities = 43/219 (19%), Positives = 69/219 (31%), Gaps = 26/219 (11%) Query: 134 DAMHKTID-KYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSL 192 A I+ +G G GG+ G + +LA KE + F + Sbjct: 39 AAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAATAKEARIAF-----------LM 87 Query: 193 LGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKH------NDLNELEQLLQSYPKSVP 246 L I N S+ H +H L + L+ ++ + Sbjct: 88 LPGVGTKDDIKEARDNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMAHTIAPE 147 Query: 247 KLIAFESVYSMAG-------SVADIEKICDLADKYGALTF-LDEVHAVGLYGPHGAGVAE 298 KL A + + AG A + +AD+ AL L E VG +G G+ Sbjct: 148 KLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVSALVAELGEDAQVGFHGHENLGLGV 207 Query: 299 HCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGK 337 + RA + + GA V+ + G K Sbjct: 208 ANSVAAVRAGAKQIDGSCRRFGAGAGNAPVEALIGVFDK 246 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.307 0.122 0.305 Lambda K H 0.267 0.0376 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,389,129 Number of Sequences: 36641 Number of extensions: 684156 Number of successful extensions: 4114 Number of sequences better than 10.0: 179 Number of HSP's better than 10.0 without gapping: 113 Number of HSP's successfully gapped in prelim test: 126 Number of HSP's that attempted gapping in prelim test: 2511 Number of HSP's gapped (non-prelim): 1041 length of query: 548 length of database: 10,336,785 effective HSP length: 102 effective length of query: 446 effective length of database: 6,599,403 effective search space: 2943333738 effective search space used: 2943333738 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 61 (28.2 bits)