BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P09624 (499 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1V59-A nrPDB 973 0.0 5J5Z-A nrPDB 549 e-157 1DXL-A nrPDB 523 e-149 3URH-A nrPDB 487 e-138 2QAE-A nrPDB 481 e-136 2YQU-A nrPDB 434 e-122 6AON-A nrPDB 433 e-121 5TR3-A nrPDB 426 e-120 5U8W-A nrPDB 413 e-115 3LAD-A nrPDB 412 e-115 6BZ0-A nrPDB 384 e-107 1EBD-A nrPDB 348 3e-96 4JDR-A nrPDB 325 3e-89 2EQ6-A nrPDB 324 4e-89 6CMZ-A nrPDB 284 7e-77 3II4-A nrPDB 268 3e-72 1LVL-A nrPDB 259 2e-69 5U25-A nrPDB 253 1e-67 1OJT-A nrPDB 249 2e-66 5X1Y-B nrPDB 230 1e-60 4YWO-A nrPDB 191 5e-49 1ZK7-A nrPDB 179 2e-45 2R9Z-A nrPDB 171 8e-43 6DU7-A nrPDB 166 3e-41 2HQM-A nrPDB 163 1e-40 2AAQ-A nrPDB 162 4e-40 1GEU-A nrPDB 161 8e-40 1ZDL-A nrPDB 159 3e-39 3L8K-A nrPDB 155 4e-38 6N7F-A nrPDB 153 2e-37 3O0H-A nrPDB 149 3e-36 2WOV-A nrPDB 144 8e-35 4LA1-A nrPDB 141 6e-34 2X8H-A nrPDB 141 6e-34 1XDI-A nrPDB 140 1e-33 4KPR-E nrPDB 138 6e-33 2CFY-A nrPDB 137 8e-33 1FEC-A nrPDB 137 1e-32 3IC9-A nrPDB 137 1e-32 2YAU-A nrPDB 136 2e-32 4DNA-A nrPDB 135 5e-32 2NVK-X nrPDB 135 6e-32 4B1B-A nrPDB 135 6e-32 5VDN-A nrPDB 132 3e-31 5U1O-A nrPDB 131 7e-31 6B4O-A nrPDB 129 3e-30 5W1J-A nrPDB 128 6e-30 4NEW-A nrPDB 127 2e-29 1ONF-A nrPDB 123 2e-28 5V36-A nrPDB 117 8e-27 3Q6J-A nrPDB 105 4e-23 3NTA-A nrPDB 67 1e-11 4GCM-A nrPDB 64 2e-10 3ICS-A nrPDB 62 5e-10 3CGD-A nrPDB 59 4e-09 5UWY-A nrPDB 58 1e-08 3IWA-A nrPDB 57 1e-08 5MJK-A nrPDB 55 8e-08 5JCN-A nrPDB 51 1e-06 1NHQ-A nrPDB 50 2e-06 5ER0-A nrPDB 50 3e-06 2BC1-A nrPDB 50 3e-06 2CDU-A nrPDB 49 7e-06 1Q1R-A nrPDB 47 2e-05 2Q7V-A nrPDB 47 2e-05 5XHU-A nrPDB 46 4e-05 2YVG-A nrPDB 46 4e-05 3AB1-A nrPDB 45 6e-05 5UTH-A nrPDB 45 1e-04 3LXD-A nrPDB 44 1e-04 4ZN0-A nrPDB 44 2e-04 4EMJ-A nrPDB 43 2e-04 3OC4-A nrPDB 42 5e-04 1FL2-A nrPDB 41 0.001 4YKF-A nrPDB 41 0.001 1YQZ-A nrPDB 41 0.002 3F8P-A nrPDB 40 0.002 2JB2-A nrPDB 39 0.005 6GAS-A nrPDB 39 0.006 3RHA-A nrPDB 38 0.009 5NA1-A nrPDB 38 0.012 1VDC-A nrPDB 37 0.015 2GMH-A nrPDB 37 0.021 3D8X-A nrPDB 36 0.030 3FG2-P nrPDB 36 0.038 2A87-A nrPDB 36 0.042 5W4C-A nrPDB 36 0.049 4MO2-B nrPDB 35 0.054 2V3B-A nrPDB 35 0.061 3LZX-A nrPDB 35 0.071 5JFC-L nrPDB 35 0.091 1QO8-A nrPDB 34 0.13 1I8T-A nrPDB 34 0.15 2VVL-G nrPDB 34 0.17 2ZBW-A nrPDB 33 0.21 4CBQ-A nrPDB 33 0.23 4YRY-B nrPDB 33 0.25 5BR7-A nrPDB 33 0.25 3MJ4-A nrPDB 33 0.26 6BPY-A nrPDB 33 0.29 3ABT-A nrPDB 33 0.31 3ISH-A nrPDB 33 0.32 1PS9-A nrPDB 33 0.34 3NIX-A nrPDB 33 0.35 5L3D-A nrPDB 33 0.37 6BWT-A nrPDB 33 0.41 5NMX-A nrPDB 33 0.41 4FX9-A nrPDB 33 0.42 3R9U-A nrPDB 32 0.50 4JNQ-A nrPDB 32 0.57 6GAR-A nrPDB 32 0.64 1F6M-A nrPDB 32 0.72 1O5W-A nrPDB 32 0.79 5TWC-A nrPDB 32 0.86 3GG2-A nrPDB 31 0.97 5VJ7-A nrPDB 31 1.1 2BXR-A nrPDB 31 1.2 5USX-A nrPDB 31 1.3 6C6P-A nrPDB 31 1.6 6CR0-A nrPDB 30 1.7 2BRY-A nrPDB 30 1.7 4Y4N-A nrPDB 30 1.8 4TXK-A nrPDB 30 1.9 5YGQ-A nrPDB 30 2.1 2CVJ-A nrPDB 30 2.9 5U63-A nrPDB 30 3.0 1REO-A nrPDB 30 3.1 4Y4M-A nrPDB 30 3.2 5X6R-A nrPDB 30 3.3 3KVE-A nrPDB 30 3.5 1F8S-A nrPDB 30 3.5 5EQD-A nrPDB 29 3.9 4Z2R-A nrPDB 29 4.5 4C3X-A nrPDB 29 5.1 2TMD-A nrPDB 29 5.2 1SEZ-A nrPDB 29 5.2 1J10-A nrPDB 29 5.6 4OVI-A nrPDB 28 8.6 6MX4-C nrPDB 28 9.5 >1V59-A nrPDB Length = 478 Score = 973 bits (2516), Expect = 0.0, Method: Compositional matrix adjust. Identities = 478/478 (100%), Positives = 478/478 (100%) Query: 22 TINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSH 81 TINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSH Sbjct: 1 TINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSH 60 Query: 82 LFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSF 141 LFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSF Sbjct: 61 LFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSF 120 Query: 142 EDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLK 201 EDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLK Sbjct: 121 EDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLK 180 Query: 202 EIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLD 261 EIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLD Sbjct: 181 EIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLD 240 Query: 262 FKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLE 321 FKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLE Sbjct: 241 FKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLE 300 Query: 322 VDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIP 381 VDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIP Sbjct: 301 VDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIP 360 Query: 382 SVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERI 441 SVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERI Sbjct: 361 SVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERI 420 Query: 442 LGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIHC 499 LGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIHC Sbjct: 421 LGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIHC 478 >5J5Z-A nrPDB Length = 496 Score = 549 bits (1415), Expect = e-157, Method: Compositional matrix adjust. Identities = 271/474 (57%), Positives = 353/474 (74%), Gaps = 11/474 (2%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMH 87 DV +IG GP GYVAAIKAAQLGF T C+EK LGGTCLNVGCIPSKALLNNSH +H H Sbjct: 30 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 89 Query: 88 -TEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETK 146 + RGI+++ ++++N+ + K AVK LTGGI LFK+NKV + G G + + Sbjct: 90 GKDFASRGIEMS-EVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQ 148 Query: 147 IRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKR 206 + T DG GT ++D KNI++ATGSEVTPFPGI IDE+ IVSSTGALSLK++P++ Sbjct: 149 VTATKADG--GT----QVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEK 202 Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGA-SMDGEVAKATQKFLKKQGLDFKLS 265 + +IG G+IG+E+GSV+ RLG+ VT VEF +G +D E++K Q+ L+KQG FKL+ Sbjct: 203 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 262 Query: 266 TKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKR 325 TKV A + D + ++ +E K E + +VLLV +GRRP+ LG E++G+E+D R Sbjct: 263 TKVTGATKKSDGKI-DVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPR 321 Query: 326 GRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMY 385 GR+ ++ +F +K P+I +GDV GPMLAHKAE+EGI VE + G H++YN +PSV+Y Sbjct: 322 GRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIY 381 Query: 386 SHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAH 445 +HPEVAWVGK+EEQLKE GI+YK+GKFPFAANSRAKTN DT+G VKIL T+R+LGAH Sbjct: 382 THPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAH 441 Query: 446 IIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAA-YDKAIH 498 I+GP AGEM+ EA LALEYGAS E +ARVCHAHPTLSEAF+EAN+AA + K+I+ Sbjct: 442 ILGPGAGEMVNEAALALEYGASCEVIARVCHAHPTLSEAFREANLAASFGKSIN 495 >1DXL-A nrPDB Length = 470 Score = 523 bits (1346), Expect = e-149, Method: Compositional matrix adjust. Identities = 265/472 (56%), Positives = 353/472 (74%), Gaps = 9/472 (1%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQM 86 +DVVIIGGGP GYVAAIKAAQLGF T C+EKRG LGGTCLNVGCIPSKALL++SH++H+ Sbjct: 7 NDVVIIGGGPGGYVAAIKAAQLGFKTTCIEKRGALGGTCLNVGCIPSKALLHSSHMYHEA 66 Query: 87 HTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETK 146 G+ V+ +++I++A KD AV LT GIE LFKKNKVTY KG G F ++ Sbjct: 67 KHSFANHGVKVS-NVEIDLAAMMGQKDKAVSNLTRGIEGLFKKNKVTYVKGYGKFVSPSE 125 Query: 147 IRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKR 206 I V ++G E+ ++ K+II+ATGS+V PG+ IDE+KIVSSTGAL+L EIPK+ Sbjct: 126 ISVDTIEG------ENTVVKGKHIIIATGSDVKSLPGVTIDEKKIVSSTGALALSEIPKK 179 Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLST 266 L +IG G IGLEMGSV+ R+GS+VTVVEF +I +MD E+ K Q+ L+KQG+ FKL T Sbjct: 180 LVVIGAGYIGLEMGSVWGRIGSEVTVVEFASEIVPTMDAEIRKQFQRSLEKQGMKFKLKT 239 Query: 267 KVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRG 326 KV+ + D V++ VE + +Q +EA+V+LV+ GR P+ +GL +KIG+E DK G Sbjct: 240 KVVGVDTSGDG--VKLTVEPSAGGEQTIIEADVVLVSAGRTPFTSGLNLDKIGVETDKLG 297 Query: 327 RLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYS 386 R++++++F++ + +GDV GPMLAHKAEE+G+A VE L GHV+Y+ +P V+Y+ Sbjct: 298 RILVNERFSTNVSGVYAIGDVIPGPMLAHKAEEDGVACVEYLAGKVGHVDYDKVPGVVYT 357 Query: 387 HPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHI 446 +PEVA VGKTEEQ+KE G++Y++GKFPF ANSRAK + EG VKI+ + +T++ILG HI Sbjct: 358 NPEVASVGKTEEQVKETGVEYRVGKFPFMANSRAKAIDNAEGLVKIIAEKETDKILGVHI 417 Query: 447 IGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIH 498 + PNAGE+I EA +AL+Y AS+ED+ARVCHAHPT+SEA KEA MA YDK IH Sbjct: 418 MAPNAGELIHEAAIALQYDASSEDIARVCHAHPTMSEAIKEAAMATYDKPIH 469 >3URH-A nrPDB Length = 491 Score = 487 bits (1253), Expect = e-138, Method: Compositional matrix adjust. Identities = 244/475 (51%), Positives = 325/475 (68%), Gaps = 11/475 (2%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQ 85 ++D+++IG GP GYV AIKAAQLG A VEKR GGTCLNVGCIPSKALL+ S +FHQ Sbjct: 25 AYDLIVIGSGPGGYVCAIKAAQLGMKVAVVEKRSTYGGTCLNVGCIPSKALLHASEMFHQ 84 Query: 86 MHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDET 145 + G++V + K+N+ KD VK G+ LFKKNK+ ++G G + Sbjct: 85 AQHGLEALGVEV-ANPKLNLQKMMAHKDATVKSNVDGVSFLFKKNKIDGFQGTGKVLGQG 143 Query: 146 KIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEI--DEEKIVSSTGALSLKEI 203 K+ VT G E+ +L+ KN+++ATGS+V PG+E+ DE+ IVSSTGAL+L+++ Sbjct: 144 KVSVTNEKG------EEQVLEAKNVVIATGSDVAGIPGVEVAFDEKTIVSSTGALALEKV 197 Query: 204 PKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFK 263 P + ++GGG+IGLE+GSV++RLG+KVTVVEF I MDGEVAK Q+ L KQG+DFK Sbjct: 198 PASMIVVGGGVIGLELGSVWARLGAKVTVVEFLDTILGGMDGEVAKQLQRMLTKQGIDFK 257 Query: 264 LSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVD 323 L KV A ++ D ++ E K + L+AEV+L+A GR+P GLG K G+ +D Sbjct: 258 LGAKVTGAVKSGDG--AKVTFEPVKGGEATTLDAEVVLIATGRKPSTDGLGLAKAGVVLD 315 Query: 324 KRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSV 383 RGR+ ID F + + +GDV GPMLAHKAE+EG+A E++ GHVNY+ IP V Sbjct: 316 SRGRVEIDRHFQTSIAGVYAIGDVVRGPMLAHKAEDEGVAVAEIIAGQAGHVNYDVIPGV 375 Query: 384 MYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILG 443 +Y+ PEVA VGKTEE+LK AG+ YKIGKFPF AN RA+ T+GFVKIL D +T+R+LG Sbjct: 376 VYTQPEVASVGKTEEELKAAGVAYKIGKFPFTANGRARAMLQTDGFVKILADKETDRVLG 435 Query: 444 AHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIH 498 HIIG AGEMI E + +E+G S+ED+ R CHAHPT+SEA KEA ++ + K IH Sbjct: 436 GHIIGFGAGEMIHEIAVLMEFGGSSEDLGRTCHAHPTMSEAVKEAALSTFFKPIH 490 >2QAE-A nrPDB Length = 468 Score = 481 bits (1239), Expect = e-136, Method: Compositional matrix adjust. Identities = 244/460 (53%), Positives = 320/460 (69%), Gaps = 11/460 (2%) Query: 41 AAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGD 100 A+IKAAQLG TACVEKRG LGGTCLNVGCIPSKALL+ +HL+H H + G+ Sbjct: 17 ASIKAAQLGMKTACVEKRGALGGTCLNVGCIPSKALLHATHLYHDAHANFARYGLMGGEG 76 Query: 101 IKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVK 160 + ++ A Q+ K+ AVK LTGG+E LFKKNKVTYYKG GSFE IRV +DG Sbjct: 77 VTMDSAKMQQQKERAVKGLTGGVEYLFKKNKVTYYKGEGSFETAHSIRVNGLDG------ 130 Query: 161 EDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMG 220 + +L+ K I+ATGSE T P + DE+ ++SSTGAL+L +PK + +IGGG+IGLE+G Sbjct: 131 KQEMLETKKTIIATGSEPTELPFLPFDEKVVLSSTGALALPRVPKTMVVIGGGVIGLELG 190 Query: 221 SVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFL-KKQGLDFKLSTKVISAKRNDDKNV 279 SV++RLG++VTVVEF P+ ++D +V A L K + + F STKV+ N D Sbjct: 191 SVWARLGAEVTVVEFAPRCAPTLDEDVTNALVGALAKNEKMKFMTSTKVVGGTNNGDSVS 250 Query: 280 VEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFP 339 +E+ + K K+E + E LLV+VGRRP+ GLG +KI + ++RG + I D F + P Sbjct: 251 LEV---EGKNGKRETVTCEALLVSVGRRPFTGGLGLDKINVAKNERGFVKIGDHFETSIP 307 Query: 340 HIKVVGDVT-FGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYSHPEVAWVGKTEE 398 + +GDV GPMLAHKAE+EG+A E+L GHVNY IP+V+Y+ PEVA VGK+E+ Sbjct: 308 DVYAIGDVVDKGPMLAHKAEDEGVACAEILAGKPGHVNYGVIPAVIYTMPEVASVGKSED 367 Query: 399 QLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAEA 458 +LK+ G+ YK+GKFPF ANSRAK +GFVK+L+D T+RILG HI+ AGE+I EA Sbjct: 368 ELKKEGVAYKVGKFPFNANSRAKAVSTEDGFVKVLVDKATDRILGVHIVCTTAGELIGEA 427 Query: 459 GLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIH 498 LA+EYGAS+EDV R CHAHPT+SEA KEA MA + K I+ Sbjct: 428 CLAMEYGASSEDVGRTCHAHPTMSEALKEACMALFAKTIN 467 >2YQU-A nrPDB Length = 455 Score = 434 bits (1117), Expect = e-122, Method: Compositional matrix adjust. Identities = 228/475 (48%), Positives = 312/475 (65%), Gaps = 23/475 (4%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQM 86 +D+++IG GP GYVAAI+AAQLG VEK LGGTCL VGCIPSKALL + + Sbjct: 2 YDLLVIGAGPGGYVAAIRAAQLGMKVGVVEKEKALGGTCLRVGCIPSKALLETTERIY-- 59 Query: 87 HTEAQK--RGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDE 144 EA+K G V G +++++ KD V+ T G+E LFKKN + ++G F E Sbjct: 60 --EAKKGLLGAKVKG-VELDLPALMAHKDKVVQANTQGVEFLFKKNGIARHQGTARFLSE 116 Query: 145 TKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIP 204 K+ V E T +E L+ + I++ATGS P ++D E++V+ST ALS E+P Sbjct: 117 RKVLV------EETGEE---LEARYILIATGSAPLIPPWAQVDYERVVTSTEALSFPEVP 167 Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKL 264 KRL ++GGG+IGLE+G V+ RLG++V V+E+ +I +MD EV++A ++ KKQGL + Sbjct: 168 KRLIVVGGGVIGLELGVVWHRLGAEVIVLEYMDRILPTMDLEVSRAAERVFKKQGLTIRT 227 Query: 265 STKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDK 324 +V + VE+ E LEA+ +LVAVGRRPY GL E GL D+ Sbjct: 228 GVRVTAVVPEAKGARVEL-------EGGEVLEADRVLVAVGRRPYTEGLSLENAGLSTDE 280 Query: 325 RGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVM 384 RGR+ +D+ ++ PHI +GDV GPMLAHKA EEGIAAVE + G GHV+Y IPSV+ Sbjct: 281 RGRIPVDEHLRTRVPHIYAIGDVVRGPMLAHKASEEGIAAVEHMVRGFGHVDYQAIPSVV 340 Query: 385 YSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGA 444 Y+HPE+A VG TEE+LK GI YK+GKFP++A+ RA+ +TEGF+K+L +KT+RILG Sbjct: 341 YTHPEIAAVGYTEEELKAQGIPYKVGKFPYSASGRARAMGETEGFIKVLAHAKTDRILGV 400 Query: 445 HIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIHC 499 H IG G+++AEA LAL + ASAED+ R HAHP+LSE KEA +AA+++ IH Sbjct: 401 HGIGARVGDVLAEAALALFFKASAEDLGRAPHAHPSLSEILKEAALAAWERPIHL 455 >6AON-A nrPDB Length = 478 Score = 433 bits (1113), Expect = e-121, Method: Compositional matrix adjust. Identities = 229/479 (47%), Positives = 313/479 (65%), Gaps = 22/479 (4%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVE--KRGK----LGGTCLNVGCIPSKAL 76 ++K DVV+IG GP GY+AAI+AAQLG + AC++ + G+ GGTC NVGCIPSKAL Sbjct: 4 MSKQFDVVVIGAGPGGYIAAIRAAQLGMSVACIDAWQNGQGGPAPGGTCTNVGCIPSKAL 63 Query: 77 LNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYK 136 L +S + Q + + GI+V G + + + K+ VKQ GI LFKKNKVTY+ Sbjct: 64 LQSSEHYEQANHHFAEHGIEVKG-VSLKLDTLIGRKNTVVKQNNDGILYLFKKNKVTYFH 122 Query: 137 GNGSFEDET----KIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIV 192 G G+F + I+VT GT D L K++IVATGS PG+ DE+ I+ Sbjct: 123 GKGAFAGQVDGGWSIKVT------GTTDAD--LVAKHVIVATGSSARELPGLPFDEKNIL 174 Query: 193 SSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQ 252 S+ GAL++ +PK+L +IG G+IGLEMGSV+ RLG++VT++E P+ A+ D +VAK Sbjct: 175 SNDGALNIGAVPKKLGVIGAGVIGLEMGSVWRRLGAEVTILEAMPEFLAAADQQVAKEAL 234 Query: 253 KFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAG 312 K KQGLD + K+ K V V D K +Q+ L + L+V++GR PY G Sbjct: 235 KSFAKQGLDIQTGVKIGEIKAAAKSITVPYV--DAKGAEQK-LVVDKLIVSIGRVPYTGG 291 Query: 313 LGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGH 372 L AE +GL++D+RG + +D+ + P++ VGDV GPMLAHKAEEEG+A E + H Sbjct: 292 LNAEAVGLKLDERGFVAVDEDCKTNLPNVWAVGDVVRGPMLAHKAEEEGVAVAERIAGQH 351 Query: 373 GHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKI 432 GHVN+ +P V+Y+ PE+AWVGKTE+QLK G +YK G FPF AN RA+ DT GF K+ Sbjct: 352 GHVNFATVPWVIYTSPEIAWVGKTEQQLKAEGREYKAGSFPFMANGRARALGDTTGFAKV 411 Query: 433 LIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMA 491 + D+KT+ +LG HIIGP A E+I+EA +E+ +AED+AR+CHAHPTLSEA KEA +A Sbjct: 412 IADAKTDEVLGVHIIGPMASELISEAVTIMEFRGAAEDIARICHAHPTLSEAVKEAALA 470 >5TR3-A nrPDB Length = 481 Score = 426 bits (1096), Expect = e-120, Method: Compositional matrix adjust. Identities = 224/482 (46%), Positives = 306/482 (63%), Gaps = 17/482 (3%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEK----RGKL--GGTCLNVGCIPSKAL 76 + + DVV+IG GP GYVAAIKAAQLG TAC+EK GKL GGTCLNVGCIPSKAL Sbjct: 4 MTQKFDVVVIGAGPGGYVAAIKAAQLGLKTACIEKYTDAEGKLALGGTCLNVGCIPSKAL 63 Query: 77 LNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYK 136 L++S + + GI G++K++VA K VK LTGG+ LFK N VT + Sbjct: 64 LDSSWKYKEAKESFNVHGIS-TGEVKMDVAAMVGRKAGIVKNLTGGVATLFKANGVTSIQ 122 Query: 137 GNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTG 196 G+G K+ VT DG +++ +N+I+A+GS P +D+ IV STG Sbjct: 123 GHGKLLAGKKVEVTKADG------TTEVIEAENVILASGSRPIDIPPAPVDQNVIVDSTG 176 Query: 197 ALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLK 256 AL + +PKRL +IG G+IGLE+GSV++RLG++VTV+E + D V+K QK L Sbjct: 177 ALEFQAVPKRLGVIGAGVIGLELGSVWARLGAEVTVLEALDTFLMAADTAVSKEAQKTLT 236 Query: 257 KQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAE 316 KQGLD KL +V +K N + E+ V T ++ + + L+VAVGRRP L A Sbjct: 237 KQGLDIKLGARVTGSKVNGN----EVEVTYTNAEGEQKITFDKLIVAVGRRPVTTDLLAS 292 Query: 317 KIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVN 376 G+ +D+RG + +DD + P + +GDV G MLAHKA EEGI VE +K +N Sbjct: 293 DSGVTIDERGYIFVDDYCATSVPGVYAIGDVVRGMMLAHKASEEGIMVVERIKGHKAQMN 352 Query: 377 YNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDS 436 Y+ IPSV+Y+HPE+AWVGKTE+ LK G++ +G FPFAA+ RA DT GFVK++ D+ Sbjct: 353 YDLIPSVIYTHPEIAWVGKTEQALKAEGVEVNVGTFPFAASGRAMAANDTGGFVKVIADA 412 Query: 437 KTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKA 496 KT+R+LG H+IGP+A E++ + +A+E+G SAED+ + +HPTLSEA EA +A A Sbjct: 413 KTDRVLGVHVIGPSAAELVQQGAIAMEFGTSAEDLGMMVFSHPTLSEALHEAALAVNGGA 472 Query: 497 IH 498 IH Sbjct: 473 IH 474 >5U8W-A nrPDB Length = 481 Score = 413 bits (1061), Expect = e-115, Method: Compositional matrix adjust. Identities = 213/482 (44%), Positives = 308/482 (63%), Gaps = 17/482 (3%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEK----RGK--LGGTCLNVGCIPSKAL 76 +++ DVV+IG GP GYVAAI+AAQLG TAC+EK GK LGGTCLNVGCIPSKAL Sbjct: 4 MSQKFDVVVIGAGPGGYVAAIRAAQLGLKTACIEKYIGKEGKVALGGTCLNVGCIPSKAL 63 Query: 77 LNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYK 136 L++S+ +H+ + GI+ G + I+V K + VK LTGGI LFK N VT ++ Sbjct: 64 LDSSYKYHEAKEAFKVHGIEAKG-VTIDVPAMVARKANIVKNLTGGIATLFKANGVTSFE 122 Query: 137 GNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTG 196 G+G ++ VT +DG + +L+ +N+I+A+GS P + ++ IV STG Sbjct: 123 GHGKLLANKQVEVTGLDG------KTQVLEAENVIIASGSRPVEIPPAPLTDDIIVDSTG 176 Query: 197 ALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLK 256 AL + +PK+L +IG G+IGLE+GSV++RLG++VTV+E + + D ++AK K L Sbjct: 177 ALEFQAVPKKLGVIGAGVIGLELGSVWARLGAEVTVLEALDKFLPAADEQIAKEALKVLT 236 Query: 257 KQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAE 316 KQGL+ +L +V +++ K V + D ++E + L+VAVGRRP L A Sbjct: 237 KQGLNIRLGARVTASEVK--KKQVTVTFTDANGEQKETFDK--LIVAVGRRPVTTDLLAA 292 Query: 317 KIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVN 376 G+ +D+RG + +DD + P + +GDV G MLAHKA EEG+ E + +N Sbjct: 293 DSGVTLDERGFIYVDDHCKTSVPGVFAIGDVVRGAMLAHKASEEGVMVAERIAGHKAQMN 352 Query: 377 YNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDS 436 Y+ IPSV+Y+HPE+AWVGKTE+ LK G++ +G FPFAA+ RA DT G VK++ D+ Sbjct: 353 YDLIPSVIYTHPEIAWVGKTEQTLKAEGVEVNVGTFPFAASGRAMAANDTTGLVKVIADA 412 Query: 437 KTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKA 496 KT+R+LG H+IGP+A E++ + + +E+G SAED+ + +HPTLSEA EA +A A Sbjct: 413 KTDRVLGVHVIGPSAAELVQQGAIGMEFGTSAEDLGMMVFSHPTLSEALHEAALAVNGHA 472 Query: 497 IH 498 IH Sbjct: 473 IH 474 >3LAD-A nrPDB Length = 476 Score = 412 bits (1058), Expect = e-115, Method: Compositional matrix adjust. Identities = 215/482 (44%), Positives = 305/482 (63%), Gaps = 17/482 (3%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEK-RGK-----LGGTCLNVGCIPSKALL 77 ++ DV++IG GP GYVAAIK+AQLG TA +EK +GK LGGTCLNVGCIPSKALL Sbjct: 1 SQKFDVIVIGAGPGGYVAAIKSAQLGLKTALIEKYKGKEGKTALGGTCLNVGCIPSKALL 60 Query: 78 NNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKG 137 ++S+ FH+ H + GI G++ I+V KD V+ LTGG+ L K N VT ++G Sbjct: 61 DSSYKFHEAHESFKLHGIS-TGEVAIDVPTMIARKDQIVRNLTGGVASLIKANGVTLFEG 119 Query: 138 NGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGA 197 +G K+ VT DG +LD +N+I+A+GS+ P +D++ IV STGA Sbjct: 120 HGKLLAGKKVEVTAADG------SSQVLDTENVILASGSKPVEIPPAPVDQDVIVDSTGA 173 Query: 198 LSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKK 257 L + +P +L +IG G+IGLE+GSV++RLG++VTV+E + ++D +VAK QK L K Sbjct: 174 LDFQNVPGKLGVIGAGVIGLELGSVWARLGAEVTVLEAMDKFLPAVDEQVAKEAQKILTK 233 Query: 258 QGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEK 317 QGL L +V + + + V+ V D + K + + L+VAVGRRP L A Sbjct: 234 QGLKILLGARVTGTEVKNKQVTVKFV--DAEGEKSQAFDK--LIVAVGRRPVTTDLLAAD 289 Query: 318 IGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNY 377 G+ +D+RG + +DD + P + +GDV G MLAHKA EEG+ E + +NY Sbjct: 290 SGVTLDERGFIYVDDYCATSVPGVYAIGDVVRGAMLAHKASEEGVVVAERIAGHKAQMNY 349 Query: 378 NNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSK 437 + IP+V+Y+HPE+A VGKTE+ LK G+ +G FPFAA+ RA DT GFVK++ D+K Sbjct: 350 DLIPAVIYTHPEIAGVGKTEQALKAEGVAINVGVFPFAASGRAMAANDTAGFVKVIADAK 409 Query: 438 TERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAI 497 T+R+LG H+IGP+A E++ + +A+E+G SAED+ + AHP LSEA EA +A AI Sbjct: 410 TDRVLGVHVIGPSAAELVQQGAIAMEFGTSAEDLGMMVFAHPALSEALHEAALAVSGHAI 469 Query: 498 HC 499 H Sbjct: 470 HV 471 >6BZ0-A nrPDB Length = 480 Score = 384 bits (986), Expect = e-107, Method: Compositional matrix adjust. Identities = 213/485 (43%), Positives = 296/485 (61%), Gaps = 22/485 (4%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKR---GK--LGGTCLNVGCIPSKALL 77 +++ D+V+IGGGP GY AAI+AAQLGF AC+EKR GK LGGTCLNVGCIPSKALL Sbjct: 4 MSQQFDLVVIGGGPGGYEAAIRAAQLGFKVACIEKRIHNGKPSLGGTCLNVGCIPSKALL 63 Query: 78 NNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKG 137 ++SH + GI G++ ++A KD V QLTGGI+ L K N + + KG Sbjct: 64 DSSHRYEDTVHHLADHGI-TTGEVNFDLAKLLARKDKIVDQLTGGIDQLLKGNGIEWLKG 122 Query: 138 NGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGA 197 G K+ P +G E IL+ K +I+A+GS P +D++ IV STGA Sbjct: 123 TGKLLAGKKVEFVPHEG------ETQILEPKYVILASGSVPVNIPVAPVDQDIIVDSTGA 176 Query: 198 LSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKK 257 L+ E+PKRL +IG G+IGLE+GSV+ RLG++V V E D ++K QK L K Sbjct: 177 LNFPEVPKRLGVIGAGVIGLELGSVWRRLGAEVVVFEAMDAFLPMADKALSKEYQKILTK 236 Query: 258 QGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEK 317 QGLD ++ KV + N E+ V+ T+ + + + L+V VGR+ Y GL AE Sbjct: 237 QGLDIRIGAKVSGTEVNGR----EVTVKYTQAGEDKEQTFDKLIVCVGRKAYAEGLLAED 292 Query: 318 IGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGH--- 374 G+++ +RG + ++D + + +GD+ GPMLAHKA EEG+ AVE + HGH Sbjct: 293 SGIKLTERGLVEVNDHCATSVEGVYAIGDLVRGPMLAHKAMEEGVMAVERI---HGHAAQ 349 Query: 375 VNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILI 434 VNY+ I S++Y+HPE AWVG TEEQ KE G + K G+F FA N RA + GFVK + Sbjct: 350 VNYDTIISIIYTHPEAAWVGLTEEQAKEKGHEVKTGQFGFAVNGRALAAGEGAGFVKFVA 409 Query: 435 DSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYD 494 D+KT+R+LG H+IGP A +++ + +ALE+ +S ED+ + HPT SE EA +A Sbjct: 410 DAKTDRLLGMHVIGPAASDIVHQGMIALEFVSSVEDLQLMTFGHPTFSEVVHEAALAVDG 469 Query: 495 KAIHC 499 +AIH Sbjct: 470 RAIHA 474 >1EBD-A nrPDB Length = 455 Score = 348 bits (893), Expect = 3e-96, Method: Compositional matrix adjust. Identities = 200/462 (43%), Positives = 279/462 (60%), Gaps = 17/462 (3%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQM- 86 + +++G GP GYVAAI+AAQLG VEK G LGG CLNVGCIPSKAL++ SH + Q Sbjct: 5 ETLVVGAGPGGYVAAIRAAQLGQKVTIVEK-GNLGGVCLNVGCIPSKALISASHRYEQAK 63 Query: 87 HTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETK 146 H+E + GI ++ I+ A Q+ K VK+LTGG+E L K NKV KG F D Sbjct: 64 HSE--EMGIKAE-NVTIDFAKVQEWKASVVKKLTGGVEGLLKGNKVEIVKGEAYFVDANT 120 Query: 147 IRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKR 206 +RV D + KN I+ATGS P + +I+ STGAL+L E+PK Sbjct: 121 VRVVNGDSAQ-------TYTFKNAIIATGSRPIELPNFKFSN-RILDSTGALNLGEVPKS 172 Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLST 266 L +IGGG IG+E+G+ Y+ G+KVT++E +I + + ++A +K LKK+G++ + Sbjct: 173 LVVIGGGYIGIELGTAYANFGTKVTILEGAGEILSGFEKQMAAIIKKRLKKKGVEVVTNA 232 Query: 267 KVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRG 326 A+ +D + V + + ++A+ +LV VGRRP LG E+IG+++ RG Sbjct: 233 LAKGAEEREDG----VTVTYEANGETKTIDADYVLVTVGRRPNTDELGLEQIGIKMTNRG 288 Query: 327 RLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYS 386 + +D Q + P+I +GD+ GP LAHKA EG A E + V+Y IP+V++S Sbjct: 289 LIEVDQQCRTSVPNIFAIGDIVPGPALAHKASYEGKVAAEAIAGHPSAVDYVAIPAVVFS 348 Query: 387 HPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHI 446 PE A VG E+Q K+ GID KFPFAAN RA DT+GF+K+++ + I+GA I Sbjct: 349 DPECASVGYFEQQAKDEGIDVIAAKFPFAANGRALALNDTDGFLKLVVRKEDGVIIGAQI 408 Query: 447 IGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEA 488 IGPNA +MIAE GLA+E G +AED+A HAHPTL E EA Sbjct: 409 IGPNASDMIAELGLAIEAGMTAEDIALTIHAHPTLGEIAMEA 450 >4JDR-A nrPDB Length = 474 Score = 325 bits (832), Expect = 3e-89, Method: Compositional matrix adjust. Identities = 186/456 (40%), Positives = 264/456 (57%), Gaps = 13/456 (2%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHT 88 VV++G GPAGY AA + A LG T VE+ LGG CLNVGCIPSKALL+ + + + Sbjct: 9 VVVLGAGPAGYSAAFRCADLGLETVIVERYNTLGGVCLNVGCIPSKALLHVAKVIEEAKA 68 Query: 89 EAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIR 148 A+ GI V G+ K ++ + K+ + QLTGG+ + K KV G G F T Sbjct: 69 LAE-HGI-VFGEPKTDIDKIRTWKEKVINQLTGGLAGMAKGRKVKVVNGLGKF---TGAN 123 Query: 149 VTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLT 208 V+G G +++ N I+A GS P I ++ +I ST AL LKE+P+RL Sbjct: 124 TLEVEGENGKT----VINFDNAIIAAGSRPIQLPFIPHEDPRIWDSTDALELKEVPERLL 179 Query: 209 IIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKV 268 ++GGGIIGLEMG+VY LGS++ VVE Q+ + D ++ K K + K+ + L TKV Sbjct: 180 VMGGGIIGLEMGTVYHALGSQIDVVEMFDQVIPAADKDIVKVFTKRISKK-FNLMLETKV 238 Query: 269 ISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRL 328 + + +D V + + K E + +LVA+GR P L A K G+EVD RG + Sbjct: 239 TAVEAKEDGIYVTM---EGKKAPAEPQRYDAVLVAIGRVPNGKNLDAGKAGVEVDDRGFI 295 Query: 329 VIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYSHP 388 +D Q + PHI +GD+ PMLAHK EG A E++ + + IPS+ Y+ P Sbjct: 296 RVDKQLRTNVPHIFAIGDIVGQPMLAHKGVHEGHVAAEVIAGKKHYFDPKVIPSIAYTEP 355 Query: 389 EVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIG 448 EVAWVG TE++ KE GI Y+ FP+AA+ RA + +G K++ D ++ R++G I+G Sbjct: 356 EVAWVGLTEKEAKEKGISYETATFPWAASGRAIASDCADGMTKLIFDKESHRVIGGAIVG 415 Query: 449 PNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEA 484 N GE++ E GLA+E G AED+A HAHPTL E+ Sbjct: 416 TNGGELLGEIGLAIEMGCDAEDIALTIHAHPTLHES 451 >2EQ6-A nrPDB Length = 464 Score = 324 bits (831), Expect = 4e-89, Method: Compositional matrix adjust. Identities = 191/479 (39%), Positives = 281/479 (58%), Gaps = 20/479 (4%) Query: 21 LTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNS 80 +T K++D+++IG GP GY AAI+AAQLG VE G++GG CLNVGCIP+KALL+ + Sbjct: 1 MTPMKTYDLIVIGTGPGGYHAAIRAAQLGLKVLAVEA-GEVGGVCLNVGCIPTKALLHAA 59 Query: 81 HLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGS 140 H + G + ++++ +D VK+LTGG+ L K N V +G Sbjct: 60 ETLHHLKV---AEGFGLKAKPELDLKKLGGWRDQVVKKLTGGVGTLLKGNGVELLRGFAR 116 Query: 141 FEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSL 200 ++ V K++I+ATGSE G E+ + ST AL + Sbjct: 117 LVGPKEVEVG-----------GERYGAKSLILATGSEPLELKGFPFGED-VWDSTRALKV 164 Query: 201 KE-IPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQG 259 +E +PKRL +IGGG +GLE+G VY RLG++VT++E+ P+I D E A ++ L+K+G Sbjct: 165 EEGLPKRLLVIGGGAVGLELGQVYRRLGAEVTLIEYMPEILPQGDPETAALLRRALEKEG 224 Query: 260 LDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIG 319 + + TK + ++ D + + +E + + E + + +LVAVGR+P GLG EK G Sbjct: 225 IRVRTKTKAVGYEKKKDG--LHVRLEPAEGGEGEEVVVDKVLVAVGRKPRTEGLGLEKAG 282 Query: 320 LEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNN 379 ++VD+RG + ++ + + P + +GD P+LAHKA EG+ A E +Y Sbjct: 283 VKVDERGFIRVNARMETSVPGVYAIGDAARPPLLAHKAMREGLIAAENAAGKDSAFDYQ- 341 Query: 380 IPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTE 439 +PSV+Y+ PE A VG TEE+ K AG K+GKFP AA+ RA T EG VK++ D +T+ Sbjct: 342 VPSVVYTSPEWAGVGLTEEEAKRAGYKVKVGKFPLAASGRALTLGGAEGMVKVVGDEETD 401 Query: 440 RILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIH 498 +LG I+GP AGE+IAEA LALE GA+ D+A H HPTLSE+ EA A + +AIH Sbjct: 402 LLLGVFIVGPQAGELIAEAALALEMGATLTDLALTVHPHPTLSESLMEAAEAFHKQAIH 460 >6CMZ-A nrPDB Length = 466 Score = 284 bits (726), Expect = 7e-77, Method: Compositional matrix adjust. Identities = 179/480 (37%), Positives = 254/480 (52%), Gaps = 25/480 (5%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLF 83 N+ +++IGGGP GYVAAI+A QLG T VE R +LGGTCLN+GCIPSKAL++ + F Sbjct: 6 NEHTTLLVIGGGPGGYVAAIRAGQLGIPTVLVE-RDRLGGTCLNIGCIPSKALIHVADAF 64 Query: 84 HQM--HTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSF 141 Q H GI V +I++A KD V +LT G+ L KK+ V G Sbjct: 65 EQACGHAGEGALGIRVRAP-EIDIAKSVAWKDGIVDRLTRGVGALLKKSGVRVLHGEARV 123 Query: 142 EDETKIRVTPVDGLEGTVKEDHILDV--KNIIVATGSEVTPFPGIEIDEEKIVSSTGALS 199 D + V V H + + +++++ATGSE P + +VSST ALS Sbjct: 124 IDGKTVEV---------VSAGHAVRIGCEHLLLATGSEPVELPSMPFGGH-VVSSTDALS 173 Query: 200 LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQG 259 +PKRL ++G G IGLE+G VY +LG V+VVE ++ + D E+ + L + G Sbjct: 174 PATLPKRLVVVGAGYIGLELGIVYRKLGVDVSVVEAAERVLPAYDAELVRPVADSLARLG 233 Query: 260 LDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIG 319 + L KV+ D V + D ++ L A+ +LVAVGRRP + G G E Sbjct: 234 VRLWLGHKVLGL---DKHGAVRVQAAD---GAEQTLPADRVLVAVGRRPRVDGFGLET-- 285 Query: 320 LEVDKRGR-LVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYN 378 L +D+ GR L IDD + ++ +GDV PMLAH+A +G E++ Sbjct: 286 LMLDRNGRALRIDDTCRTSMRNVWAIGDVAGEPMLAHRAMAQGEMVAELIAGRRRQFMPA 345 Query: 379 NIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKT 438 IP+V ++ PE+ G + + AG+D FPFAAN RA T Q T+GFV+++ Sbjct: 346 AIPAVCFTDPEIVTAGWSPDDAHAAGVDCLSASFPFAANGRAMTLQATDGFVRVVARRDN 405 Query: 439 ERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIH 498 I+G +G E+ A +LE GA ED+ HAHPTL EA +EA + A A+H Sbjct: 406 HLIVGWQAVGRGVSELAAAFSQSLEMGARLEDIGGTIHAHPTLGEALQEAALRALGHALH 465 >3II4-A nrPDB Length = 466 Score = 268 bits (686), Expect = 3e-72, Method: Compositional matrix adjust. Identities = 175/465 (37%), Positives = 248/465 (53%), Gaps = 20/465 (4%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQM 86 +DVV++G GP GYVAAI+AAQLG +TA VE + GG CLNVGCIPSKALL N+ L H Sbjct: 6 YDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPK-YWGGVCLNVGCIPSKALLRNAELVHIF 64 Query: 87 HTEAQKRGI--DVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDE 144 +A+ GI +V D I +K + V G+ L KKNK+T G G+F D Sbjct: 65 TKDAKAFGISGEVTFDYGIAYDRSRKVAEGRV----AGVHFLMKKNKITEIHGYGTFADA 120 Query: 145 TKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIP 204 + V DG +V D N I+ATGS PG + + LS +E+P Sbjct: 121 NTLLVDLNDGGTESVTFD------NAIIATGSSTRLVPGTSLSANVVTYEEQILS-RELP 173 Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKL 264 K + I G G IG+E G V G VT+VEF P+ + D +V+K +K KK G+ Sbjct: 174 KSIIIAGAGAIGMEFGYVLKNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTILT 233 Query: 265 STKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDK 324 +TKV S ++ V TK + L+AE +L A+G P + G G +K G+ + Sbjct: 234 ATKVESIADGGS----QVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTD 289 Query: 325 RGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHV--NYNNIPS 382 R + +DD + HI +GDV LAH AE +G+ A E + ++ +P Sbjct: 290 RKAIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTLGDHRMLPR 349 Query: 383 VMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERIL 442 + P VA G TE+Q + G D + KFPF AN++A D GFVK++ D+K +L Sbjct: 350 ATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAKAHGVGDPSGFVKLVADAKHGELL 409 Query: 443 GAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKE 487 G H++G + E++ E LA + +A ++AR H HPT+SEA +E Sbjct: 410 GGHLVGHDVAELLPELTLAQRWDLTASELARNVHTHPTMSEALQE 454 >1LVL-A nrPDB Length = 458 Score = 259 bits (661), Expect = 2e-69, Method: Compositional matrix adjust. Identities = 174/472 (36%), Positives = 255/472 (54%), Gaps = 24/472 (5%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMH- 87 ++IIGGGP GYVAAI+A QLG T VE + LGGTCLN+GCIPSKAL++ + FHQ Sbjct: 8 LLIIGGGPGGYVAAIRAGQLGIPTVLVEGQA-LGGTCLNIGCIPSKALIHVAEQFHQASR 66 Query: 88 -TEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETK 146 TE GI V ++++ KD V +LT G+ L KK+ V G D + Sbjct: 67 FTEPSPLGISVASP-RLDIGQSVAWKDGIVDRLTTGVAALLKKHGVKVVHGWAKVLDGKQ 125 Query: 147 IRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKR 206 + V DG + +++++ATGS P + + ++SST AL+ K +P+ Sbjct: 126 VEV---DGQR--------IQCEHLLLATGSSSVELPMLPLGG-PVISSTEALAPKALPQH 173 Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLST 266 L ++GGG IGLE+G Y +LG++V+VVE + +I + D E+ + LKK G+ L Sbjct: 174 LVVVGGGYIGLELGIAYRKLGAQVSVVEARERILPTYDSELTAPVAESLKKLGIALHLGH 233 Query: 267 KVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRG 326 V + ++ D K Q LEA+ +LVAVGRRP G E + L+++ Sbjct: 234 SVEGYENGC------LLANDGK-GGQLRLEADRVLVAVGRRPRTKGFNLECLDLKMNGAA 286 Query: 327 RLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYS 386 + ID++ + ++ +GDV PMLAH+A +G E++ I +V ++ Sbjct: 287 -IAIDERCQTSMHNVWAIGDVAGEPMLAHRAMAQGEMVAEIIAGKARRFEPAAIAAVCFT 345 Query: 387 HPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHI 446 PEV VGKT EQ + G+D + +FPFAAN RA + + GFV+++ ILG Sbjct: 346 DPEVVVVGKTPEQASQQGLDCIVAQFPFAANGRAMSLESKSGFVRVVARRDNHLILGWQA 405 Query: 447 IGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIH 498 +G E+ +LE GA EDVA HAHPTL EA +EA + A A+H Sbjct: 406 VGVAVSELSTAFAQSLEMGACLEDVAGTIHAHPTLGEAVQEAALRALGHALH 457 >5U25-A nrPDB Length = 602 Score = 253 bits (647), Expect = 1e-67, Method: Compositional matrix adjust. Identities = 181/455 (39%), Positives = 255/455 (56%), Gaps = 18/455 (3%) Query: 39 YVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVN 98 Y AA AA G A VE+ LGG CLNVGCIPSKALL+N+ + ++ R + N Sbjct: 138 YSAAFAAADEGLKVAIVERYKTLGGVCLNVGCIPSKALLHNAAVIDEV------RHLAAN 191 Query: 99 G----DIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFED--ETKIRVTPV 152 G + ++++ + KD V +LTGG+ + K KV +G+G F D ++ +T Sbjct: 192 GIKYPEPELDIDMLRAYKDGVVSRLTGGLAGMAKSRKVDVIQGDGQFLDPHHLEVSLTAG 251 Query: 153 DGLE--GTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTII 210 D E E I+ KN I+A GS VT P I ++ +I+ S+GAL+LKE+P +L II Sbjct: 252 DAYEQAAPTGEKKIVAFKNCIIAAGSRVTKLPFIP-EDPRIIDSSGALALKEVPGKLLII 310 Query: 211 GGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVIS 270 GGGIIGLEMG+VYS LGS++ VVE + D ++ K QK + + + ++TK ++ Sbjct: 311 GGGIIGLEMGTVYSTLGSRLDVVEMMDGLMQGADRDLVKVWQKQNEYRFDNIMVNTKTVA 370 Query: 271 AKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVI 330 + +D V + E K E + +LVA GR P + AEK G+ V RG + + Sbjct: 371 VEPKEDG--VYVTFEGANAPK-EPQRYDAVLVAAGRAPNGKLISAEKAGVAVTDRGFIEV 427 Query: 331 DDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYSHPEV 390 D Q + PHI +GD+ PMLAHKA EG A E + + IP V Y+ PEV Sbjct: 428 DKQMRTNVPHIYAIGDIVGQPMLAHKAVHEGHVAAENCAGHKAYFDARVIPGVAYTSPEV 487 Query: 391 AWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPN 450 AWVG+TE K +G FP+AA+ RA N GF K++ D++T RI+G I+GPN Sbjct: 488 AWVGETELSAKASGRKITKANFPWAASGRAIANGCDNGFTKLIFDAETGRIIGGGIVGPN 547 Query: 451 AGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAF 485 G+MI E LA+E G A D+ + H HPTL E+ Sbjct: 548 GGDMIGEVCLAIEMGCDAADIGKTIHPHPTLGESI 582 >1OJT-A nrPDB Length = 482 Score = 249 bits (636), Expect = 2e-66, Method: Compositional matrix adjust. Identities = 179/455 (39%), Positives = 254/455 (55%), Gaps = 18/455 (3%) Query: 39 YVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVN 98 Y AA AA G A VE+ LGG CLNVGCIPSKALL+N+ + ++ R + N Sbjct: 19 YSAAFAAADEGLKVAIVERYKTLGGVCLNVGCIPSKALLHNAAVIDEV------RHLAAN 72 Query: 99 G----DIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFED--ETKIRVTPV 152 G + ++++ + KD V +LTGG+ + K KV +G+G F D ++ +T Sbjct: 73 GIKYPEPELDIDMLRAYKDGVVSRLTGGLAGMAKSRKVDVIQGDGQFLDPHHLEVSLTAG 132 Query: 153 DGLE--GTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTII 210 D E E I+ KN I+A GS VT P I ++ +I+ S+GAL+LKE+P +L II Sbjct: 133 DAYEQAAPTGEKKIVAFKNCIIAAGSRVTKLPFIP-EDPRIIDSSGALALKEVPGKLLII 191 Query: 211 GGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVIS 270 GGGIIGLEMG+VYS LGS++ VVE + D ++ K QK + + + ++TK ++ Sbjct: 192 GGGIIGLEMGTVYSTLGSRLDVVEMMDGLMQGADRDLVKVWQKQNEYRFDNIMVNTKTVA 251 Query: 271 AKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVI 330 + +D V + E K E + +LVA GR P + AEK G+ V RG + + Sbjct: 252 VEPKEDG--VYVTFEGANAPK-EPQRYDAVLVAAGRAPNGKLISAEKAGVAVTDRGFIEV 308 Query: 331 DDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYSHPEV 390 D Q + PHI +GD+ PMLAHKA EG A E + + IP V Y+ PEV Sbjct: 309 DKQMRTNVPHIYAIGDIVGQPMLAHKAVHEGHVAAENCAGHKAYFDARVIPGVAYTSPEV 368 Query: 391 AWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPN 450 AWVG+TE K + FP+AA+ RA N + F K++ D++T RI+G I+GPN Sbjct: 369 AWVGETELSAKASARKITKANFPWAASGRAIANGCDKPFTKLIFDAETGRIIGGGIVGPN 428 Query: 451 AGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAF 485 G+MI E LA+E G A D+ + H HPTL E+ Sbjct: 429 GGDMIGEVCLAIEMGCDAADIGKTIHPHPTLGESI 463 >5X1Y-B nrPDB Length = 554 Score = 230 bits (586), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 149/475 (31%), Positives = 254/475 (53%), Gaps = 23/475 (4%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQ 85 ++D++IIG G A + +AIKA + G +E RG +GGTC+N+GC+PSK LL + H Sbjct: 84 NYDLLIIGSGAAAFSSAIKAIEYGAKVGMIE-RGTVGGTCVNIGCVPSKTLLRAGEIIH- 141 Query: 86 MHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIEL-LFKKNKVTYYKGNGSFEDE 144 + + G+ + ++++A+ KD V +L + L + KG F D Sbjct: 142 LSKDNPFIGLQTSAG-EVDLASLITQKDKLVSELRNQKYMDLIDEYNFDLIKGEAKFVDA 200 Query: 145 TKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIE-IDEEKIVSSTGALSLKEI 203 + + V L K ++ATG+ + P I +++ ++ST L LK+I Sbjct: 201 STVEVNGAK-----------LSAKRFLIATGASPS-LPQISGLEKMDYLTSTTLLELKKI 248 Query: 204 PKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFK 263 PKRLT+IG G IG+E+G ++ LGS++T+++ ++ D E++++ +K L +QG++ Sbjct: 249 PKRLTVIGSGYIGMELGQLFHHLGSEITLMQRSERLLKEYDPEISESVEKALIEQGINLV 308 Query: 264 LSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVD 323 +++ + V + V ++ E +E++ LLVA GR+P L G+E Sbjct: 309 KGATFERVEQSGEIKRVYVTVNGSR----EVIESDQLLVATGRKPNTDSLNLSAAGVETG 364 Query: 324 KRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEG-IAAVEMLKTGHGHVNYNNIPS 382 K ++I+D + I GDVT GP + A EG I + + ++ + +P+ Sbjct: 365 KNNEILINDFGQTSNEKIYAAGDVTLGPQFVYVAAYEGGIITDNAIGGLNKKIDLSVVPA 424 Query: 383 VMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERIL 442 V +++P VA VG TEEQ KE G D K P A RA N++T G K++ D++T ++L Sbjct: 425 VTFTNPTVATVGLTEEQAKEKGYDVKTSVLPLDAVPRAIVNRETTGVFKLVADAETLKVL 484 Query: 443 GAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAI 497 G HI+ NAG++I A LA+++G + ED+ + T++E K A + +DK I Sbjct: 485 GVHIVSENAGDVIYAASLAVKFGLTVEDLTETLAPYLTMAEGLKLAAL-TFDKDI 538 >4YWO-A nrPDB Length = 462 Score = 191 bits (486), Expect = 5e-49, Method: Compositional matrix adjust. Identities = 140/472 (29%), Positives = 241/472 (51%), Gaps = 44/472 (9%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQM 86 H + IIG G AG+ A IKA +LG + K G++GGTC+NVGC+PSK +L + ++ Sbjct: 16 HKLAIIGYGAAGFAAMIKANELGVKPVLIGK-GEIGGTCVNVGCVPSKRMLYIAEIY--- 71 Query: 87 HTEAQKRGIDVNG-DIKINVANFQKAKDDAVKQLTGG-IELLFKKNKVTYYKGNGSFEDE 144 K+ +V G ++ ++FQ+ KD V+++ E L V +G F Sbjct: 72 -----KKAREVTGSEVYPPFSSFQE-KDGLVQEMRKTKYEDLLSYYDVELIQGEARFISP 125 Query: 145 TKIRVTPVDGLEGTVKEDHILDVKNIIVATGSE--VTPFPGIEIDEEKIVSSTGALSLKE 202 ++V +++ + ++ATGS + PG+ D+ ++ ALS Sbjct: 126 HAVKVN-----------GQVIEAEKFVIATGSSPLIPRIPGL--DKVGFWTNREALSPDR 172 Query: 203 IPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDF 262 L +IGG + LE +YSR+ +V +++ P + + E + ++ ++ G+ Sbjct: 173 RIDSLAVIGGRALALEFAQMYSRMKVEVAILQRSPVLIPDWEPEASVEARRIMENDGVAV 232 Query: 263 KLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEV 322 V ++ K V+ T+K E +EA+ +L+A GR+P + LG E G+ + Sbjct: 233 VTGVNVKEVRKGAGKIVI--------TDKGE-VEADEILLATGRKPNV-DLGLENAGVRL 282 Query: 323 DKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTG-HGHVNYNNIP 381 ++RG + +DD+ + PHI GDV G ML A +G A E TG H V+ N +P Sbjct: 283 NERGGIKVDDELRTDNPHIYAAGDVLGGKMLEALAGRQGSIATENALTGSHKRVDENAVP 342 Query: 382 SVMYSHPEVAWVGKTEEQL--KEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTE 439 V+++ P +A VG TE + KE ++ ++ P ++ ++A+ GFVK++ + Sbjct: 343 QVIFTQPNLARVGLTEAEARAKEGEVEARV--LPMSSVAKAEIINSRLGFVKMV--TMNG 398 Query: 440 RILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMA 491 RI+G H +G N EMI EA LA+ +GA+ D+ H PT++E+ + +A Sbjct: 399 RIVGVHAVGENVAEMIGEAALAIRFGATVHDLIDTVHMFPTIAESLRLVALA 450 >1ZK7-A nrPDB Length = 467 Score = 179 bits (455), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 141/469 (30%), Positives = 224/469 (47%), Gaps = 33/469 (7%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHT 88 V +IG G A AA+KA + G +E RG +GGTC+NVGC+PSK ++ +H+ H Sbjct: 7 VAVIGSGGAAMAAALKAVEQGAQVTLIE-RGTIGGTCVNVGCVPSKIMIRAAHIAHL--- 62 Query: 89 EAQKRGIDVNGDIKINVANFQKAKDDAVKQLT------GGIELLFKKNK-VTYYKGNGSF 141 +R +G I V ++K A +Q E + N +T G F Sbjct: 63 ---RRESPFDGGIAATVPTIDRSKLLAQQQARVDELRHAKYEGILGGNPAITVVHGEARF 119 Query: 142 EDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSE--VTPFPGIEIDEEKIVSSTGALS 199 +D+ + V +G E V D L VATG+ V P PG++ E +ST AL+ Sbjct: 120 KDDQSLTVRLNEGGERVVMFDRCL------VATGASPAVPPIPGLK--ESPYWTSTEALA 171 Query: 200 LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQG 259 IP+RL +IG ++ LE+ ++RLGSKVTV+ + + D + +A + +G Sbjct: 172 SDTIPERLAVIGSSVVALELAQAFARLGSKVTVLA-RNTLFFREDPAIGEAVTAAFRAEG 230 Query: 260 LDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIG 319 ++ T+ D + V+ T L A+ LLVA GR P L + G Sbjct: 231 IEVLEHTQASQVAHMDGEFVL--------TTTHGELRADKLLVATGRTPNTRSLALDAAG 282 Query: 320 LEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNN 379 + V+ +G +VID + P+I GD T P + A G A + G ++ Sbjct: 283 VTVNAQGAIVIDQGMRTSNPNIYAAGDCTDQPQFVYVAAAAGTRAAINMTGGDAALDLTA 342 Query: 380 IPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTE 439 +P+V+++ P+VA VG +E + GI+ RA N DT GF+K++I+ + Sbjct: 343 MPAVVFTDPQVATVGYSEAEAHHDGIETDSRTLTLDNVPRALANFDTRGFIKLVIEEGSH 402 Query: 440 RILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEA 488 R++G + P AGE+I A LA+ + +++A + T+ E K A Sbjct: 403 RLIGVQAVAPEAGELIQTAALAIRNRMTVQELADQLFPYLTMVEGLKLA 451 >2R9Z-A nrPDB Length = 463 Score = 171 bits (432), Expect = 8e-43, Method: Compositional matrix adjust. Identities = 130/466 (27%), Positives = 219/466 (46%), Gaps = 29/466 (6%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHL 82 + + D++ IGGG G A KAA G A +E + LGGTC+NVGC+P K + SHL Sbjct: 1 MTQHFDLIAIGGGSGGLAVAEKAAAFGKRVALIESK-ALGGTCVNVGCVPKKVMWYASHL 59 Query: 83 FHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFE 142 + +A G+ +G ++ +D + + + ++ +T G+ F Sbjct: 60 AEAVR-DAPGFGVQASGG-TLDWPRLVAGRDRYIGAINSFWDGYVERLGITRVDGHARFV 117 Query: 143 DETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSE--VTPFPGIEIDEEKIVSSTGALSL 200 D I V E L +I++ATG V PG E+ ++S G +L Sbjct: 118 DAHTIEV-----------EGQRLSADHIVIATGGRPIVPRLPGAELG----ITSDGFFAL 162 Query: 201 KEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGL 260 ++ PKR+ IIG G IG+E+ + GS+VTVV + ++ D ++ + + QG+ Sbjct: 163 QQQPKRVAIIGAGYIGIELAGLLRSFGSEVTVVALEDRLLFQFDPLLSATLAENMHAQGI 222 Query: 261 DFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGL 320 + L V + +R D +V +D + E ++ ++ AVGR P LG E G+ Sbjct: 223 ETHLEFAVAALER--DAQGTTLVAQD--GTRLEGFDS--VIWAVGRAPNTRDLGLEAAGI 276 Query: 321 EVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGH--VNYN 378 EV G + D N+ P + +GD+T L A G E L G ++Y+ Sbjct: 277 EVQSNGMVPTDAYQNTNVPGVYALGDITGRDQLTPVAIAAGRRLAERLFDGQSERKLDYD 336 Query: 379 NIPSVMYSHPEVAWVGKTEEQLKE-AGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSK 437 NIP+V+++HP ++ VG +E + +E G + + F A + +K++ Sbjct: 337 NIPTVVFAHPPLSKVGLSEPEARERLGDVLTVYETSFTPMRYALNEHGPKTAMKLVCAGP 396 Query: 438 TERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSE 483 +R++G H+IG A EM+ +A++ GA+ D HP +E Sbjct: 397 EQRVVGVHVIGDGADEMLQGFAVAVKMGATKADFDNTVAIHPGSAE 442 >6DU7-A nrPDB Length = 448 Score = 166 bits (419), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 126/448 (28%), Positives = 211/448 (47%), Gaps = 30/448 (6%) Query: 44 KAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIKI 103 +A + G A +E++ KLGGTC+NVGC+P K + + + H + G D+ Sbjct: 21 RAGEHGAQAAVIEEK-KLGGTCVNVGCVPKKIMWYGAQIAETFHQFGEDYGFKTT-DLNF 78 Query: 104 NVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDH 163 + A ++ ++ + + + FK+N V +G+ F D + V Sbjct: 79 DFATLRRNRESYIDRARSSYDGSFKRNGVDLIEGHAEFVDSHTVSVN-----------GE 127 Query: 164 ILDVKNIIVATGSE--VTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGS 221 ++ K+I++ATG+ + PG E+ SS + +E+P+ + I+G G I +E+ Sbjct: 128 LIRAKHIVIATGAHPSIPNIPGAELGG----SSDDVFAWEELPESVAILGAGYIAVELAG 183 Query: 222 VYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVE 281 V G K + + + D + + K +++ L L T + K + + Sbjct: 184 VLHTFGVKTDLFVRRDRPLRGFDSYIVEGLVKEMERTNL--PLHTHKVPVKLEKTTDGIT 241 Query: 282 IVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHI 341 I ED ++ A ++ A GRRP + GL EK G+ +++RG + +D+ N+ I Sbjct: 242 IHFEDGTSHT-----ASQVIWATGRRPNVKGLQLEKAGVTLNERGFIQVDEYQNTVVEGI 296 Query: 342 KVVGDVTFGPMLAHKAEEEGIAAVEMLKTGH--GHVNYNNIPSVMYSHPEVAWVGKTEEQ 399 +GDVT L A + G E L G ++Y+ IP+V++SHP + VG TEEQ Sbjct: 297 YALGDVTGEKELTPVAIKAGRTLSERLFNGKTTAKMDYSTIPTVVFSHPAIGTVGLTEEQ 356 Query: 400 -LKEAGIDY-KIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAE 457 +KE G D K+ K FA+ A T E K++ E+++G H IG EMI Sbjct: 357 AIKEYGQDQIKVYKSSFASMYSACTRNRQESRFKLITAGSEEKVVGLHGIGYGVDEMIQG 416 Query: 458 AGLALEYGASAEDVARVCHAHPTLSEAF 485 +A++ GA+ D HPT SE F Sbjct: 417 FAVAIKMGATKADFDATVAIHPTSSEEF 444 >2HQM-A nrPDB Length = 479 Score = 163 bits (413), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 131/476 (27%), Positives = 236/476 (49%), Gaps = 31/476 (6%) Query: 22 TINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSH 81 T K +D ++IGGG G +A +AA G T VE + LGGTC+NVGC+P K + S Sbjct: 7 TNTKHYDYLVIGGGSGGVASARRAASYGAKTLLVEAKA-LGGTCVNVGCVPKKVMWYASD 65 Query: 82 LFHQMHTEAQKRGIDVN-----GDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYK 136 L ++ + A + G+ N + N F++ +D V +L G + +K KV Sbjct: 66 LATRV-SHANEYGLYQNLPLDKEHLTFNWPEFKQKRDAYVHRLNGIYQKNLEKEKVDVVF 124 Query: 137 GNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSE-VTP--FPGIEIDEEKIVS 193 G F + + V D +HIL VATG + + P PG E+ + Sbjct: 125 GWARFNKDGNVEVQKRDNTTEVYSANHIL------VATGGKAIFPENIPGFELGTD---- 174 Query: 194 STGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQK 253 S G L+E PK++ ++G G IG+E+ V+ LGS+ +V + D + Sbjct: 175 SDGFFRLEEQPKKVVVVGAGYIGIELAGVFHGLGSETHLVIRGETVLRKFDECIQNTITD 234 Query: 254 FLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGL 313 K+G++ +K++ ++N + + ++I + D+K+ + + L+ +GR+ ++ G+ Sbjct: 235 HYVKEGINVHKLSKIVKVEKNVETDKLKIHMNDSKSID----DVDELIWTIGRKSHL-GM 289 Query: 314 GAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEML----K 369 G+E +G++++ +++ D+ N+ P+I +GDV L A G L K Sbjct: 290 GSENVGIKLNSHDQIIADEYQNTNVPNIYSLGDVVGKVELTPVAIAAGRKLSNRLFGPEK 349 Query: 370 TGHGHVNYNNIPSVMYSHPEVAWVGKTEEQL--KEAGIDYKIGKFPFAANSRAKTNQDTE 427 + ++Y N+PSV++SHPE +G +E++ K + K+ F A A ++ + Sbjct: 350 FRNDKLDYENVPSVIFSHPEAGSIGISEKEAIEKYGKENIKVYNSKFTAMYYAMLSEKSP 409 Query: 428 GFVKILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSE 483 KI+ E+++G HI+G ++ E++ G+A++ GA+ D HPT +E Sbjct: 410 TRYKIVCAGPNEKVVGLHIVGDSSAEILQGFGVAIKMGATKADFDNCVAIHPTSAE 465 >2AAQ-A nrPDB Length = 479 Score = 162 bits (409), Expect = 4e-40, Method: Compositional matrix adjust. Identities = 136/464 (29%), Positives = 223/464 (48%), Gaps = 17/464 (3%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQ 85 S+D ++IGGG G +A +AA+LG A VE KLGGTC+NVGC+P K + N + Sbjct: 21 SYDYLVIGGGSGGLASARRAAELGARAAVVESH-KLGGTCVNVGCVPKKVMWNTAVHSEF 79 Query: 86 MHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDET 145 MH A G K N ++ +D V +L + K+ + +G+ +F + Sbjct: 80 MHDHADYGFPSCEG--KFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP 137 Query: 146 KIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPK 205 K + V G + T HIL + +T E + PG + ++S G L+E+P Sbjct: 138 KPTIE-VSGKKYTAP--HILIATGGMPSTPHE-SQIPGASLG----ITSDGFFQLEELPG 189 Query: 206 RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLS 265 R I+G G I +EM + S LGSK +++ ++ S D ++ + L+ G++ Sbjct: 190 RSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKF 249 Query: 266 TKVISAKRNDDKNVVEIVVEDTKTNKQENL--EAEVLLVAVGRRPYIAGLGAEKIGLEVD 323 ++V K+ V +V + + + LL A+GR P L K+G++ D Sbjct: 250 SQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD 309 Query: 324 KRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEML--KTGHGHVNYNNIP 381 +G +++D+ N+ I VGDV +L A G L ++YNNIP Sbjct: 310 DKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIP 369 Query: 382 SVMYSHPEVAWVGKTE-EQLKEAGID-YKIGKFPFAANSRAKTNQDTEGFVKILIDSKTE 439 +V++SHP + VG TE E + + GI+ K F A T + T+ +K++ +K E Sbjct: 370 TVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEE 429 Query: 440 RILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSE 483 +++G H+ G EM+ +A++ GA+ D HPT SE Sbjct: 430 KVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSE 473 >1GEU-A nrPDB Length = 450 Score = 161 bits (407), Expect = 8e-40, Method: Compositional matrix adjust. Identities = 126/448 (28%), Positives = 208/448 (46%), Gaps = 29/448 (6%) Query: 44 KAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIKI 103 +AA G A +E + +LGGTC+NVGC+P K + + + + +H G D + K Sbjct: 22 RAAMYGQKCALIEAK-ELGGTCVNVGCVPKKVMWHAAQIREAIHMYGPDYGFDTTIN-KF 79 Query: 104 NVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDH 163 N ++ + ++ E + KN V KG F D + V T+ DH Sbjct: 80 NWETLIASRTAYIDRIHTSYENVLGKNNVDVIKGFARFVDAKTLEVN-----GETITADH 134 Query: 164 ILDVKNIIVATGSEVT--PFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGS 221 IL +ATG + PG+E + S G +L +P+R+ ++G G IG+E+G Sbjct: 135 IL------IATGGRPSHPDIPGVEYG----IDSDGFFALPALPERVAVVGAGYIGVELGG 184 Query: 222 VYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVE 281 V + LG+K + E S D +++ + + +G + + +N D ++ Sbjct: 185 VINGLGAKTHLFEMFDAPLPSFDPMISETLVEVMNAEGPQLHTNAIPKAVVKNTDGSLT- 243 Query: 282 IVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHI 341 + +ED ++ + L+ A+GR P + E G++ +++G +V+D N+ I Sbjct: 244 LELEDGRSET-----VDCLIWAIGREPANDNINLEAAGVKTNEKGYIVVDKYQNTNIEGI 298 Query: 342 KVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHG--HVNYNNIPSVMYSHPEVAWVGKTEEQ 399 VGD T L A G E L H++Y+NIP+V++SHP + VG TE Q Sbjct: 299 YAVGDNTGAVELTPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIGTVGLTEPQ 358 Query: 400 LKEAGID--YKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAE 457 +E D K+ K F A A T +K++ E+I+G H IG EM+ Sbjct: 359 AREQYGDDQVKVYKSSFTAMYTAVTTHRQPCRMKLVCVGSEEKIVGIHGIGFGMDEMLQG 418 Query: 458 AGLALEYGASAEDVARVCHAHPTLSEAF 485 +AL+ GA+ +D HPT +E F Sbjct: 419 FAVALKMGATKKDFDNTVAIHPTAAEEF 446 >1ZDL-A nrPDB Length = 517 Score = 159 bits (402), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 132/481 (27%), Positives = 223/481 (46%), Gaps = 36/481 (7%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVE-----KRGK---LGGTCLNVGCIPSKA 75 +S D+++IGGG G A +AAQLG A + RG LGGTC+NVGCIP K Sbjct: 30 QQSFDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKK- 88 Query: 76 LLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYY 135 L++ + L M +A G +V ++ N +A + VK L G + + KV Y+ Sbjct: 89 LMHQAALLGGMIRDAHHYGWEVAQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKYF 148 Query: 136 KGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSST 195 SF DE +R G + +L ++I++ATG ++ E ++S Sbjct: 149 NIKASFVDEHTVRGVDKGG------KATLLSAEHIVIATGGRPRYPTQVKGALEYGITSD 202 Query: 196 GALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFL 255 LKE P + ++G + LE + +G TV+ + D +++ + + Sbjct: 203 DIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTVMMRSIPL-RGFDQQMSSLVTEHM 261 Query: 256 KKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGA 315 + G F L V S + N +++ ED + K++ + +L A+GR P L Sbjct: 262 ESHGTQF-LKGCVPSHIKKLPTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNL 320 Query: 316 EKIGLEVD-KRGRLVIDDQFNSKFPHIKVVGDVTFG-PMLAHKAEEEG-IAAVEMLKTGH 372 EK G+ + K ++++D Q + PHI +GDV G P L A + G + A + Sbjct: 321 EKAGISTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSS 380 Query: 373 GHVNYNNIPSVMYSHPEVAWVGKTEEQ---------LKEAGIDYKIGKFPFAANSRAKTN 423 ++Y+N+P+ +++ E VG +EE+ ++ YK +F A ++ Sbjct: 381 TLMDYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRDASQC- 439 Query: 424 QDTEGFVK-ILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLS 482 ++K + + + +LG H +GPNAGE+ L ++ GAS V + HPT S Sbjct: 440 -----YIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHPTCS 494 Query: 483 E 483 E Sbjct: 495 E 495 >3L8K-A nrPDB Length = 466 Score = 155 bits (391), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 129/473 (27%), Positives = 231/473 (48%), Gaps = 45/473 (9%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQM 86 +DVV+IG G AGY A + A+ +N + +G+LGG CL GC+PSK + ++ Sbjct: 5 YDVVVIGAGGAGYHGAFRLAKAKYNVLMADPKGELGGNCLYSGCVPSKTV-------REV 57 Query: 87 HTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNK--------VTYYKGN 138 A + N I ++ + Q KD EL FK++K +T+YKG Sbjct: 58 IQTAWRLTNIANVKIPLDFSTVQDRKDYVQ-------ELRFKQHKRNMSQYETLTFYKGY 110 Query: 139 GSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPF--PGIE--IDEEKIVSS 194 +D T + V +G E + + +I+A+G+E PG+E + + I Sbjct: 111 VKIKDPTHVIVKTDEGKEIEA------ETRYMIIASGAETAKLRLPGVEYCLTSDDIFGY 164 Query: 195 TGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASM-DGEVAKATQK 253 S +++P+ + IIG G IGLE+ S++ +G + ++E + ++ D ++ Sbjct: 165 KT--SFRKLPQDMVIIGAGYIGLEIASIFRLMGVQTHIIEMLDRALITLEDQDIVNTLLS 222 Query: 254 FLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGL 313 LK L+ K ++ V K+ D V+ TK ++++ +++A GRRP I Sbjct: 223 ILK---LNIKFNSPVTEVKKIKDDEYE--VIYSTKDGSKKSIFTNSVVLAAGRRPVIPE- 276 Query: 314 GAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHG 373 GA +IGL + K G +V+D+ + P++ GD H A IAA + Sbjct: 277 GAREIGLSISKTG-IVVDETMKTNIPNVFATGDANGLAPYYHAAVRMSIAAANNIMANGM 335 Query: 374 HVNY---NNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFV 430 V+Y +IP +Y+ P +++VG + ++ GI+ ++ + A+ EG + Sbjct: 336 PVDYVDVKSIPVTIYTIPSLSYVGILPSKARKMGIEIVEAEYNMEEDVSAQIYGQKEGVL 395 Query: 431 KILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSE 483 K++ + + R++GA +IG ++ +I E GLA+ YG +A+ +A HP+ +E Sbjct: 396 KLIFERGSMRLIGAWMIGVHSQYLINELGLAVAYGLNAKQLASFAEQHPSTNE 448 >6N7F-A nrPDB Length = 453 Score = 153 bits (386), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 125/463 (26%), Positives = 212/463 (45%), Gaps = 25/463 (5%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQM 86 +D ++IGGG AG +A +AA G E + ++GGTC+N+GC+P K + + + + Sbjct: 8 YDYIVIGGGSAGIASANRAAMHGAKVLLAEGK-EIGGTCVNLGCVPKKVMWYGAQVADIL 66 Query: 87 HTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETK 146 T A+ G D + + + + + ++ E F++N V F+D Sbjct: 67 GTYAKDYGFDFK-EKAFDFKQLKANRQAYIDRIHASYERGFEQNGVDRIYDYAVFKDAHT 125 Query: 147 IRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKR 206 + + + +I++ATG FP IE + I SS G +L E+PKR Sbjct: 126 VEIA-----------GQLYTAPHILIATGGHPV-FPDIEGAQYGI-SSDGFFALDEVPKR 172 Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLST 266 ++G G I +E+ V LGSK + + S D + + G Sbjct: 173 TAVVGAGYIAVELAGVLHALGSKTDLFIRHDRPLRSFDKTIVDVLVDEMAVNGPRLHTHA 232 Query: 267 KVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRG 326 +V +N D+++ + ++D + +E + L+ A+GR+P + G +K G+ ++ +G Sbjct: 233 EVAKVVKNTDESLT-LYLKDG-----QEVEVDQLIWAIGRKPNLEGFSLDKTGVTLNDKG 286 Query: 327 RLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGH--VNYNNIPSVM 384 + D N+ I VGDV L A G E L G ++Y N+ +V+ Sbjct: 287 YIETDAYENTSVKGIYAVGDVNGKLALTPVAVAAGRRLSERLFNGKTDEKLDYQNVATVI 346 Query: 385 YSHPEVAWVGKTEEQ-LKEAGID-YKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERIL 442 +SHP + VG +EE +K+ G + K + F + A TN +K++ TE+I+ Sbjct: 347 FSHPVIGSVGLSEEAAVKQYGQEAVKTYQSRFTSMFTAITNHRQPCLMKLVTVGDTEKIV 406 Query: 443 GAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAF 485 G H IG EMI +A++ GA+ D HPT SE F Sbjct: 407 GLHGIGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEF 449 >3O0H-A nrPDB Length = 484 Score = 149 bits (376), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 119/463 (25%), Positives = 222/463 (47%), Gaps = 33/463 (7%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMH 87 D+ +IG G G AA A LG A E+ ++GGTC+ GC+P K + + + Sbjct: 28 DLFVIGSGSGGVRAARLAGALGKRVAIAEEY-RIGGTCVIRGCVPKKL-----YFYASQY 81 Query: 88 TEAQKRGIDVNGDIKINVANFQK---AKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDE 144 + + I + N++K AK+ + +L G + + V Y+ F DE Sbjct: 82 AQEFSKSIGFGWKYADPIFNWEKLVAAKNKEISRLEGLYREGLQNSNVHIYESRAVFVDE 141 Query: 145 TKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIP 204 LE +V + I + I++ATG+++ I+ + ++S L+++P Sbjct: 142 HT--------LELSVTGERI-SAEKILIATGAKIVSNSAIK-GSDLCLTSNEIFDLEKLP 191 Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKL 264 K + I+GGG IG+E +++ LG K T++ I + D ++ + + +G+ Sbjct: 192 KSIVIVGGGYIGVEFANIFHGLGVKTTLLHRGDLILRNFDYDLRQLLNDAMVAKGISIIY 251 Query: 265 STKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDK 324 V ++ +N +V+ + +T + A+ +++A GR P GLG E+ G++V++ Sbjct: 252 EATV--SQVQSTENCYNVVLTNGQT-----ICADRVMLATGRVPNTTGLGLERAGVKVNE 304 Query: 325 RGRLVIDDQFNSKFPHIKVVGDVT----FGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNI 380 G +V+D++ + HI VGDVT P+ H A A E T +Y+ I Sbjct: 305 FGAVVVDEKMTTNVSHIWAVGDVTGHIQLTPVAIHDAMCFVKNAFENTSTTP---DYDLI 361 Query: 381 PSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTER 440 + ++S PE+ VG +EE +I + F + + F+K+++D ++ Sbjct: 362 TTAVFSQPEIGTVGLSEEDALHRYKRVEIYRTVFRPMRNVLSGSPEKMFMKLVVDGESRI 421 Query: 441 ILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSE 483 ++GAH++G NAGE+ G++L+ + + + HPT+SE Sbjct: 422 VVGAHVLGENAGEIAQLIGISLKGKLTKDIFDKTMAVHPTMSE 464 >2WOV-A nrPDB Length = 495 Score = 144 bits (363), Expect = 8e-35, Method: Compositional matrix adjust. Identities = 133/494 (26%), Positives = 217/494 (43%), Gaps = 41/494 (8%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQL-GFNTACVEKR--------GKLGGTCLNVGCIPS 73 ++K+ D+V+IG G G A AA L G A V+ + LGGTC+NVGC+P Sbjct: 4 MSKAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPK 63 Query: 74 KALLNNSHLFHQMHTEAQKRGIDVNGD-IKINVANFQKAKDDAVKQLTGGIELLFKKNK- 131 K ++ + + E+ G + +G +K N AK++AV + E +F + Sbjct: 64 KLMVTGAQYMDHLR-ESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEG 122 Query: 132 VTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGS--EVTPFPGIEIDEE 189 + ++ G GS E + + V + VKE L +I++ATGS ++ PGIE Sbjct: 123 LDFFLGWGSLESKNVVVVRETADPKSAVKER--LQADHILLATGSWPQMPAIPGIE---- 176 Query: 190 KIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSV---YSRLGSKVTVVEFQPQIGASMDGE 246 +SS A L E P+R+ +GGG I +E + Y G KVT+ I D Sbjct: 177 HCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDET 236 Query: 247 VAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGR 306 + + K L G++ + N D + + E KT L+ +V+++A+GR Sbjct: 237 IREEVTKQLTANGIEIMTNENPAKVSLNTDGSK-HVTFESGKT-----LDVDVVMMAIGR 290 Query: 307 RPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVE 366 P L +G+++ +G + +D+ + P+I +GD+T ML A EG A V+ Sbjct: 291 IPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVD 350 Query: 367 ML------KTGHGHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRA 420 + KT H + S ++S P + G EE + + F Sbjct: 351 TVFGNKPRKTDH-----TRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHN 405 Query: 421 KTNQDTEGFV-KILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHP 479 + + FV KI+ + +LG H++G A E+I G+ L A D HP Sbjct: 406 ISGSKYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHP 465 Query: 480 TLSEAFKEANMAAY 493 T +E +Y Sbjct: 466 TSAEELCSMRTPSY 479 >4LA1-A nrPDB Length = 602 Score = 141 bits (356), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 118/438 (26%), Positives = 203/438 (46%), Gaps = 22/438 (5%) Query: 61 LGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVN-GDIKINVANFQKAKDDAVKQL 119 LGGTC+NVGCIP K L++ + L +AQ G ++ +I + + + + L Sbjct: 156 LGGTCVNVGCIPKK-LMHQAGLLSHSLEDAQHFGWSLDKSEISHDWSTMVEGVQSHIGSL 214 Query: 120 TGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVT 179 G ++ + N VTY G ++++T + T+ + II+ATG E Sbjct: 215 NWGYKVSLRDNAVTYLNARGMLLSPHEVQITEKNKKVSTITGN------KIILATG-ERP 267 Query: 180 PFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQI 239 +P I E ++S SL P + ++G + L+ + LG VTV+ + + Sbjct: 268 KYPEIPGAIEYGITSDDLFSLPYFPGKTLVVGASYVALKCAGFLASLGGDVTVM-VRSIL 326 Query: 240 GASMDGEVAKATQKFLKKQGLDF-KLS-----TKVISAKRNDDKNVVEIVVEDTKTNKQE 293 D ++A+ +++ G+ F KL T++ ++K + +V K+ Sbjct: 327 LRGFDQQMAEKVGDYMENHGVKFAKLCVPDEITQLKPVDTENNKPGLLLVKGHYTDGKKF 386 Query: 294 NLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFG-PM 352 E E ++ AVGR P ++ L E +G+++DK GR+V D + +I +GD+ G P Sbjct: 387 EEEFETVIFAVGREPQLSKLNCEAVGVKLDKNGRVVCSDDEQTTVSNIYAIGDINAGKPQ 446 Query: 353 LAHKAEEEGIAAVEMLKTGHGHV-NYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGK 411 L A G L G + +Y+N+ + +++ E G +EE E D I Sbjct: 447 LTPVAIHAGRYLARRLFAGATELTDYSNVATTVFTPLEYGACGLSEEDAIEKYGDNDIEV 506 Query: 412 FPFAANSRAKT---NQDTEGFVKILID-SKTERILGAHIIGPNAGEMIAEAGLALEYGAS 467 + T +D ++K++ S R+LG H++GPNAGE+ +A++ GA+ Sbjct: 507 YHSHFKPLEWTVAHREDNVCYMKLVCRISDNMRVLGLHVLGPNAGEITQGYAVAIKMGAT 566 Query: 468 AEDVARVCHAHPTLSEAF 485 ED R HPT SE F Sbjct: 567 KEDFDRTIGIHPTCSETF 584 >2X8H-A nrPDB Length = 598 Score = 141 bits (356), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 131/488 (26%), Positives = 222/488 (45%), Gaps = 46/488 (9%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVE--------KRGKLGGTCLNVGCIPSKALLN 78 +D+++IGGG G A +AA+ G TA ++ LGGTC+NVGCIP K L++ Sbjct: 108 YDLIVIGGGSGGLAAGKEAAKYGAKTAVLDYVEPTPIGTTWGLGGTCVNVGCIPKK-LMH 166 Query: 79 NSHLFHQMHTEAQKRGIDVN-GDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKG 137 + L +A+ G ++ I N + + + L G ++ + N+VTY Sbjct: 167 QAGLLSHALEDAEHFGWSLDRSKISHNWSTMVEGVQSHIGSLNWGYKVALRDNQVTYLNA 226 Query: 138 NGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGA 197 G ++++T + T+ + II+ATG E +P I E ++S Sbjct: 227 KGRLISPHEVQITDKNQKVSTITGN------KIILATG-ERPKYPEIPGAVEYGITSDDL 279 Query: 198 LSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKK 257 SL P + +IG + LE + LG VTV+ + + D ++A+ +++ Sbjct: 280 FSLPYFPGKTLVIGASYVALECAGFLASLGGDVTVM-VRSILLRGFDQQMAEKVGDYMEN 338 Query: 258 QGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENL--------------EAEVLLVA 303 G+ F AK + ++ V DT+ NK L E E ++ A Sbjct: 339 HGVKF--------AKLCVPDEIKQLKVVDTENNKPGLLLVKGHYTDGKKFEEEFETVIFA 390 Query: 304 VGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFG-PMLAHKAEEEGI 362 VGR P ++ + E +G+++DK GR+V D + ++ +GD+ G P L A + G Sbjct: 391 VGREPQLSKVLCETVGVKLDKNGRVVCTDDEQTTVSNVYAIGDINAGKPQLTPVAIQAGR 450 Query: 363 AAVEMLKTGHGHV-NYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAK 421 L G + +Y+N+ + +++ E G +EE E D I + Sbjct: 451 YLARRLFAGATELTDYSNVATTVFTPLEYGACGLSEEDAIEKYGDKDIEVYHSNFKPLEW 510 Query: 422 T---NQDTEGFVKILI-DSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHA 477 T +D ++K++ S R+LG H++GPNAGE+ +A++ GA+ D R Sbjct: 511 TVAHREDNVCYMKLVCRKSDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKADFDRTIGI 570 Query: 478 HPTLSEAF 485 HPT SE F Sbjct: 571 HPTCSETF 578 >1XDI-A nrPDB Length = 499 Score = 140 bits (353), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 125/479 (26%), Positives = 215/479 (44%), Gaps = 28/479 (5%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVE--KRGKLGGTCLNVGCIPSKALLNNSHLFHQM 86 +VI+GGGPAGY AA+ AA T V +GG + C+PSK + ++ L ++ Sbjct: 5 IVILGGGPAGYEAALVAATSHPETTQVTVIDCDGIGGAAVLDDCVPSKTFIASTGLRTEL 64 Query: 87 HTEAQKRGIDVN-GDIKINVANFQ-KAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDE 144 A G ++ D KI++ + K A Q + I V G G D Sbjct: 65 R-RAPHLGFHIDFDDAKISLPQIHARVKTLAAAQ-SADITAQLLSMGVQVIAGRGELIDS 122 Query: 145 T------KIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGAL 198 T +I+ T DG +H DV ++VATG+ P + D E+I++ Sbjct: 123 TPGLARHRIKATAADG----STSEHEADV--VLVATGASPRILPSAQPDGERILTWRQLY 176 Query: 199 SLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQ 258 L +P L ++G G+ G E Y+ LG VTVV Q + D + A ++ ++ Sbjct: 177 DLDALPDHLIVVGSGVTGAEFVDAYTELGVPVTVVASQDHVLPYEDADAALVLEESFAER 236 Query: 259 GLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKI 318 G+ + + S R V + + D +T +E L+ +G P +GLG E++ Sbjct: 237 GVRLFKNARAASVTRTGAG--VLVTMTDGRT-----VEGSHALMTIGSVPNTSGLGLERV 289 Query: 319 GLEVDKRGRLVIDDQFNSKFPHIKVVGDVT-FGPMLAHKAEEEGIAAVEMLKTGHGHVNY 377 G+++ + L +D + I GD T P+ + A + IA L G + Sbjct: 290 GIQLGRGNYLTVDRVSRTLATGIYAAGDCTGLLPLASVAAMQGRIAMYHALGEGVSPIRL 349 Query: 378 NNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSK 437 + + +++ PE+A VG + + + + P N+RAK ++ GFVKI Sbjct: 350 RTVAATVFTRPEIAAVGVPQSVIDAGSVAARTIMLPLRTNARAKMSEMRHGFVKIFCRRS 409 Query: 438 TERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEA--NMAAYD 494 T ++G ++ P A E+I +A++ + ++A+ +P+LS + EA + A+D Sbjct: 410 TGVVIGGVVVAPIASELILPIAVAVQNRITVNELAQTLAVYPSLSGSITEAARRLMAHD 468 >4KPR-E nrPDB Length = 499 Score = 138 bits (347), Expect = 6e-33, Method: Compositional matrix adjust. Identities = 112/439 (25%), Positives = 204/439 (46%), Gaps = 22/439 (5%) Query: 58 RGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVK 117 R LGGTC+NVGCIP K L++ + L Q +++ G + +K + ++ + + Sbjct: 52 RWGLGGTCVNVGCIPKK-LMHQAALLGQALKDSRNYGWKLEDTVKHDWEKMTESVQNHIG 110 Query: 118 QLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSE 177 L G + ++ KV Y G F KI T G E + + ++ATG E Sbjct: 111 SLNWGYRVALREKKVVYENAYGKFIGPHKIMATNNKGKE------KVYSAERFLIATG-E 163 Query: 178 VTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQP 237 + GI D+E +SS SL P + ++G + LE + +G VTV+ + Sbjct: 164 RPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVM-VRS 222 Query: 238 QIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEA 297 + D ++A + +++ G+ F ++ + + V TN +E +E Sbjct: 223 ILLRGFDQDMANKIGEHMEEHGIKFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIED 282 Query: 298 E--VLLVAVGRRPYIAGLGAEKIGLEV-DKRGRLVIDDQFNSKFPHIKVVGDVTFGPM-L 353 E +L+AVGR +G E +G+++ +K G++ + D+ + P+I +GD+ G + L Sbjct: 283 EFNTVLLAVGRDSCTRTIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLEL 342 Query: 354 AHKAEEEGIAAVEMLKTGHG-HVNYNNIPSVMYSHPEVAWVGKTEEQ----LKEAGID-Y 407 A + G + L G +Y+N+P+ +++ E G +EE+ E I+ Y Sbjct: 343 TPVAIQAGRLLAQRLYGGSTVKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVY 402 Query: 408 KIGKFPFAANSRAKTNQDTEGFVKILIDSK-TERILGAHIIGPNAGEMIAEAGLALEYGA 466 +P ++ N + K++ + K ER++G H++GPNAGE+ AL+ G Sbjct: 403 HSFFWPLEWTVPSRDNNKC--YAKVICNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGL 460 Query: 467 SAEDVARVCHAHPTLSEAF 485 + + + HP +E F Sbjct: 461 TKQQLDSTIGIHPVCAEIF 479 >2CFY-A nrPDB Length = 521 Score = 137 bits (346), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 113/439 (25%), Positives = 205/439 (46%), Gaps = 22/439 (5%) Query: 58 RGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVK 117 R LGGTC+NVGCIP K L++ + L Q +++ G V +K + +A + + Sbjct: 74 RWGLGGTCVNVGCIPKK-LMHQAALLGQALQDSRNYGWKVEETVKHDWDRMIEAVQNHIG 132 Query: 118 QLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSE 177 L G + ++ KV Y G F +I+ T G E I + ++ATG E Sbjct: 133 SLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKE------KIYSAERFLIATG-E 185 Query: 178 VTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQP 237 + GI D+E +SS SL P + ++G + LE + +G VTV+ + Sbjct: 186 RPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVM-VRS 244 Query: 238 QIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEA 297 + D ++A + +++ G+ F I ++ + + V TN +E +E Sbjct: 245 ILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEG 304 Query: 298 E--VLLVAVGRRPYIAGLGAEKIGLEV-DKRGRLVIDDQFNSKFPHIKVVGDVTFGPM-L 353 E +++A+GR +G E +G+++ +K G++ + D+ + P+I +GD+ + L Sbjct: 305 EYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVEL 364 Query: 354 AHKAEEEGIAAVEMLKTGHG-HVNYNNIPSVMYSHPEVAWVGKTEEQ----LKEAGID-Y 407 A + G + L G +Y N+P+ +++ E G +EE+ E I+ Y Sbjct: 365 TPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVY 424 Query: 408 KIGKFPFAANSRAKTNQDTEGFVKILIDSK-TERILGAHIIGPNAGEMIAEAGLALEYGA 466 +P ++ N + KI+ ++K ER++G H++GPNAGE+ AL+ G Sbjct: 425 HSYFWPLEWTIPSRDNNKC--YAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGL 482 Query: 467 SAEDVARVCHAHPTLSEAF 485 + + + HP +E F Sbjct: 483 TKKQLDSTIGIHPVCAEVF 501 >1FEC-A nrPDB Length = 490 Score = 137 bits (344), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 128/492 (26%), Positives = 217/492 (44%), Gaps = 39/492 (7%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACV---------EKRGKLGGTCLNVGCIPSK 74 ++++D+V+IG G G A AA L V LGGTC+NVGC+P K Sbjct: 1 SRAYDLVVIGAGSGGLEAGWNAASLHKKRVAVIDLQKHHGPPHYAALGGTCVNVGCVPKK 60 Query: 75 ALLNNSHLFHQMHTEAQKRGIDVNGD-IKINVANFQKAKDDAVKQLTGGIELLFKKNK-V 132 ++ ++ + E+ G +++ + ++ N AK+ AV + E +F + + Sbjct: 61 LMVTGANYMDTIR-ESAGFGWELDRESVRPNWKALIAAKNKAVSGINDSYEGMFADTEGL 119 Query: 133 TYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFP---GIEIDEE 189 T+++G G+ +D + V V E LD + I++ATGS +P GIE D+ Sbjct: 120 TFHQGFGALQDNHTVLVRESADPNSAVLE--TLDTEYILLATGS----WPQHLGIEGDD- 172 Query: 190 KIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSV---YSRLGSKVTVVEFQPQIGASMDGE 246 ++S A L E PKR +GGG I +E + Y G +V + I D E Sbjct: 173 LCITSNEAFYLDEAPKRALCVGGGYISIEFAGIFNAYKARGGQVDLAYRGDMILRGFDSE 232 Query: 247 VAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGR 306 + K + L+ G++ + +N D +V E + +V+++A+GR Sbjct: 233 LRKQLTEQLRANGINVRTHENPAKVTKNAD-GTRHVVFE-----SGAEADYDVVMLAIGR 286 Query: 307 RPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVE 366 P L EK G+EV K G + +D + +I +GDVT ML A EG A V+ Sbjct: 287 VPRSQTLQLEKAGVEVAKNGAIKVDAYSKTNVDNIYAIGDVTDRVMLTPVAINEGAAFVD 346 Query: 367 MLKTGHGH-VNYNNIPSVMYSHPEVAWVGKTEE----QLKEAGIDYKIGKFPFAANSRAK 421 + ++ + ++S P + G EE + + + Y+ P N Sbjct: 347 TVFANKPRATDHTKVACAVFSIPPMGVCGYVEEDAAKKYDQVAV-YESSFTPLMHNISGS 405 Query: 422 TNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTL 481 T + + V+I+ + +LG H++G ++ E+I + L+ GA D HPT Sbjct: 406 TYK--KFMVRIVTNHADGEVLGVHMLGDSSPEIIQSVAICLKMGAKISDFYNTIGVHPTS 463 Query: 482 SEAFKEANMAAY 493 +E AY Sbjct: 464 AEELCSMRTPAY 475 >3IC9-A nrPDB Length = 492 Score = 137 bits (344), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 124/478 (25%), Positives = 215/478 (44%), Gaps = 42/478 (8%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHL-FHQM 86 DV IIG G AG + A +AA+ + + + G G TC VGC+PSK L+ + +H Sbjct: 10 DVAIIGTGTAG-MGAYRAAKKHTDKVVLIEGGAYGTTCARVGCMPSKLLIAAADASYHAS 68 Query: 87 HTEA---QKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFED 143 T+ Q I VNG K + Q +D V + +E +++K+ +G F D Sbjct: 69 QTDLFGIQVDRISVNG--KAVMKRIQTERDRFVGFVVESVESFDEQDKI---RGFAKFLD 123 Query: 144 ETKIRVTPVDGLEGTVKEDHI-LDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKE 202 E ++V +DH + K I++ATGS + +++++ L + Sbjct: 124 EHTLQV-----------DDHSQVIAKRIVIATGSRPNYPEFLAAAGSRLLTNDNLFELND 172 Query: 203 IPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDF 262 +PK + + G G+IGLE+G SRLG V V + D E+ + +K ++ F Sbjct: 173 LPKSVAVFGPGVIGLELGQALSRLGVIVKVFGRSGSVANLQDEEMKRYAEKTFNEE-FYF 231 Query: 263 KLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEV 322 +VIS +D VE++ D K+ ++ + +L A GR+ + LG E +E+ Sbjct: 232 DAKARVISTIEKED--AVEVIYFD-KSGQKTTESFQYVLAATGRKANVDKLGLENTSIEL 288 Query: 323 DKRGRLVIDD-QFNSKFPHIKVVGDVTFGPMLAHKAEEEG------IAAVEMLKTGHGHV 375 DK+ + D+ + HI V GD L H+A ++G A ++ G Sbjct: 289 DKKNSPLFDELTLQTSVDHIFVAGDANNTLTLLHEAADDGKVAGTNAGAYPVIAQGQRRA 348 Query: 376 NYNNIPSVMYSHPEVAWVGKTEEQLKEAGID-----YKIGKFPFAANSRAKTNQDTEGFV 430 SV+++ P+VA VG + Q+++ D Y +G+ F R++ +G + Sbjct: 349 PL----SVVFTEPQVASVGLSLRQIEDLYADQDAANYVVGQVSFEGQGRSRVMGKNKGLL 404 Query: 431 KILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEA 488 + D + LGA + GP A + A + + + + + HP + E + A Sbjct: 405 NVYADRTSGEFLGAEMFGPAAEHIGHLLAWARQQQMTVQAMLTMPFYHPVIEEGLRTA 462 >2YAU-A nrPDB Length = 511 Score = 136 bits (342), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 123/498 (24%), Positives = 215/498 (43%), Gaps = 49/498 (9%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKR----------------GKLGGTCL 66 +++++D+V++G G G A G+N A K+ LGGTC+ Sbjct: 21 MSRAYDLVVLGAGSGGLEA-------GWNAAVTHKKKVAVVDVQATHGPPLFAALGGTCV 73 Query: 67 NVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGD-IKINVANFQKAKDDAVKQLTGGIEL 125 NVGC+P K ++ + + + E+ G +++ + + N AK+ V + + Sbjct: 74 NVGCVPKKLMVTGAQ-YMDLIRESGGFGWEMDRESLCPNWKTLIAAKNKVVNSINESYKS 132 Query: 126 LFKKNK-VTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPF--P 182 +F + ++++ G G+ +D + V + V E LD + I++ATGS T P Sbjct: 133 MFADTEGLSFHMGFGALQDAHTVVVRKSEDPHSDVLE--TLDTEYILIATGSWPTRLGVP 190 Query: 183 GIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSV---YSRLGSKVTVVEFQPQI 239 G +E ++S A L++ PKR+ +GGG I +E + Y G V + I Sbjct: 191 G----DEFCITSNEAFYLEDAPKRMLCVGGGYIAVEFAGIFNGYKPCGGYVDLCYRGDLI 246 Query: 240 GASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEV 299 D EV K+ K L G+ + + +N+D + N + + Sbjct: 247 LRGFDTEVRKSLTKQLGANGIRVRTNLNPTKITKNEDGS------NHVHFNDGTEEDYDQ 300 Query: 300 LLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEE 359 +++A+GR P L +K G+ K G + +D + +I +GDVT ML A Sbjct: 301 VMLAIGRVPRSQALQLDKAGVRTGKNGAVQVDAYSKTSVDNIYAIGDVTNRVMLTPVAIN 360 Query: 360 EGIAAVEMLKTGHGH-VNYNNIPSVMYSHPEVAWVGKTEEQLK---EAGIDYKIGKFPFA 415 EG A VE + G ++ + ++S P + G TEE+ E Y P Sbjct: 361 EGAAFVETVFGGKPRATDHTKVACAVFSIPPIGTCGMTEEEAAKNYETVAVYASSFTPLM 420 Query: 416 ANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVC 475 N ++ E ++I+ + +LG H++G +A E+I G+ ++ GA D Sbjct: 421 HNISGSKHK--EFMIRIITNESNGEVLGVHMLGDSAPEIIQSVGICMKMGAKISDFHSTI 478 Query: 476 HAHPTLSEAFKEANMAAY 493 HPT +E AY Sbjct: 479 GVHPTSAEELCSMRTPAY 496 >4DNA-A nrPDB Length = 463 Score = 135 bits (339), Expect = 5e-32, Method: Compositional matrix adjust. Identities = 111/453 (24%), Positives = 211/453 (46%), Gaps = 26/453 (5%) Query: 45 AAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIKIN 104 AA LG A E+ + GGTC+ GC+P K + S F + +A G V G+ + + Sbjct: 24 AAALGKKVAIAEEF-RYGGTCVIRGCVPKKLYVYASQ-FAEHFEDAAGFGWTV-GESRFD 80 Query: 105 VANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHI 164 A AK+ + +L G L++K G+ +T+ + + ++ + Sbjct: 81 WAKLVAAKEQEIARLEG----LYRKG----LANAGAEILDTRAELAGPNTVK-LLASGKT 131 Query: 165 LDVKNIIVATGSEVTP---FPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGS 221 + + I++A G +P PG E+ ++S A L +P+ + I GGG I +E + Sbjct: 132 VTAERIVIAVGGHPSPHDALPGHEL----CITSNEAFDLPALPESILIAGGGYIAVEFAN 187 Query: 222 VYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVE 281 ++ LG K T++ +I + D ++ + ++++G+ + S + D V Sbjct: 188 IFHGLGVKTTLIYRGKEILSRFDQDMRRGLHAAMEEKGIRILCEDIIQSVSADADGRRV- 246 Query: 282 IVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHI 341 T K + A+ +++A+GR P GLG E G+ ++ G +++D + P I Sbjct: 247 -----ATTMKHGEIVADQVMLALGRMPNTNGLGLEAAGVRTNELGAIIVDAFSRTSTPGI 301 Query: 342 KVVGDVTFGPMLAHKAEEEGIAAVEM-LKTGHGHVNYNNIPSVMYSHPEVAWVGKTEEQL 400 +GDVT L A E + +E K +++ I + ++S PE+ VG TEE+ Sbjct: 302 YALGDVTDRVQLTPVAIHEAMCFIETEYKNNPTSPDHDLIATAVFSQPEIGTVGITEEEA 361 Query: 401 KEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAEAGL 460 + ++ + F + + + +K+++++ +++GAHI+G +AGEM G+ Sbjct: 362 ARKFQEIEVYRAEFRPMKATLSGRKEKTIMKLVVNAADRKVVGAHILGHDAGEMAQLLGI 421 Query: 461 ALEYGASAEDVARVCHAHPTLSEAFKEANMAAY 493 +L G + +D R HPT +E +Y Sbjct: 422 SLRAGCTKDDFDRTMAVHPTAAEELVTMYQPSY 454 >2NVK-X nrPDB Length = 488 Score = 135 bits (339), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 124/480 (25%), Positives = 217/480 (45%), Gaps = 39/480 (8%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVE---------KRGKLGGTCLNVGCIPSKALL 77 +D+++IGGG AG A +A G AC++ + +GGTC+NVGCIP K + Sbjct: 10 YDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKKLMH 69 Query: 78 NNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKG 137 S L +H EA G +V+ IK + ++ + +K + + + KV Y G Sbjct: 70 QASLLGEAVH-EAAAYGWNVDDKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEYING 128 Query: 138 NGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGA 197 GSF D + G + + + ++A G +P I E ++S Sbjct: 129 LGSFVDSHTLLAKLKSG-------ERTITAQTFVIAVGGRPR-YPDIPGAVEYGITSDDL 180 Query: 198 LSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKK 257 SL P + ++G G IGLE LG + TV+ + + D ++A+ +++ Sbjct: 181 FSLDREPGKTLVVGAGYIGLECAGFLKGLGYEPTVM-VRSIVLRGFDQQMAELVAASMEE 239 Query: 258 QGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEK 317 +G+ F T +S ++ DD ++ + ++ +T ++ + +L A+GR+ + L Sbjct: 240 RGIPFLRKTVPLSVEKQDDGKLL-VKYKNVETGEESEDVYDTVLWAIGRKGLVDDLNLPN 298 Query: 318 IGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFG-PMLAHKAEEEGIAAVEMLKTGHGH-V 375 G+ V K ++ +D Q + +I VGD+ +G P L A G L G + Sbjct: 299 AGVTVQKD-KIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRM 357 Query: 376 NYNNIPSVMYSHPEVAWVGKTEEQ-LKEAGID--------YKIGKFPFAANSRAKTNQDT 426 +Y ++ + +++ E A VG +EE +K+ G D YK +F S Sbjct: 358 DYKDVATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQKSVRYC---- 413 Query: 427 EGFVKILIDSK-TERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAF 485 ++K + + +R+ G H IGP AGE+I AL+ G + + HPT +E F Sbjct: 414 --YLKAVAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEF 471 >4B1B-A nrPDB Length = 542 Score = 135 bits (339), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 126/488 (25%), Positives = 221/488 (45%), Gaps = 42/488 (8%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLG-----FNTACVEKRGK---LGGTCLNVGCIPSKALLN 78 +D V+IGGGP G +A +AA G F+ +G +GGTC+NVGC+P K + Sbjct: 43 YDYVVIGGGPGGMASAKEAAAHGARVLLFDYVKPSSQGTKWGIGGTCVNVGCVPKKLMHY 102 Query: 79 NSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGN 138 H+ +++ G + ++K + ++ L + +KV Y G Sbjct: 103 AGHMGSIFKLDSKAYGWKFD-NLKHDWKKLVTTVQSHIRSLNFSYMTGLRSSKVKYINGL 161 Query: 139 GSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGAL 198 +D+ + L+G + ++ + K I++ATG +E +E ++S Sbjct: 162 AKLKDKNTVSYY----LKGDLSKEETVTGKYILIATGCRPHIPDDVEGAKELSITSDDIF 217 Query: 199 SLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQ 258 SLK+ P + ++G + LE + LG VTV + + D + A + ++++Q Sbjct: 218 SLKKDPGKTLVVGASYVALECSGFLNSLGYDVTVA-VRSIVLRGFDQQCAVKVKLYMEEQ 276 Query: 259 GLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKI 318 G+ FK + DDK +VE ++K L + +L A+GR+ I GL E + Sbjct: 277 GVMFKNGILPKKLTKMDDKILVEF------SDKTSEL-YDTVLYAIGRKGDIDGLNLESL 329 Query: 319 GLEVDKRGRLVIDDQFN-SKFPHIKVVGDVTFG-PMLAHKAEEEG-IAAVEMLKTGHGHV 375 + V+K +I D + + P I VGDV P LA A + G I A + K + Sbjct: 330 NMNVNKSNNKIIADHLSCTNIPSIFAVGDVAENVPELAPVAIKAGEILARRLFKDSDEIM 389 Query: 376 NYNNIPSVMYSHPEVAWVGKTEEQLKE----AGIDYKIGKF---PFAANSRAK------- 421 +Y+ IP+ +Y+ E G +EE+ E + ++ + +F +A R K Sbjct: 390 DYSYIPTSIYTPIEYGACGYSEEKAYELYGKSNVEVFLQEFNNLEISAVHRQKHIRAQKD 449 Query: 422 ---TNQDTEGFVKIL-IDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHA 477 + + K++ + ++ R++G H +GPNAGE+ LAL +D Sbjct: 450 EYDLDVSSTCLAKLVCLKNEDNRVIGFHYVGPNAGEVTQGMALALRLKVKKKDFDNCIGI 509 Query: 478 HPTLSEAF 485 HPT +E+F Sbjct: 510 HPTDAESF 517 >5VDN-A nrPDB Length = 463 Score = 132 bits (332), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 120/451 (26%), Positives = 201/451 (44%), Gaps = 35/451 (7%) Query: 44 KAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDV---NGD 100 +AA G A +E + +LGGTC+NVGC+P K + + + + +H G D + D Sbjct: 35 RAAMYGKKCALIEAK-QLGGTCVNVGCVPKKVMWHAAQIAEAIHLYGPDYGFDTTVNHFD 93 Query: 101 IKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVK 160 K +AN + A D + Q E NKV +G F D + V T+ Sbjct: 94 WKKLIAN-RTAYIDRIHQ---SYERGLGNNKVDVIQGFARFVDAHTVEVN-----GETIT 144 Query: 161 EDHILDVKNIIVATGSEVT--PFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLE 218 DHIL +ATG + PG E + S G L E+PKR+ ++G G I +E Sbjct: 145 ADHIL------IATGGRPSHPDIPGAEYG----IDSDGFFELDEMPKRVAVVGAGYIAVE 194 Query: 219 MGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKN 278 + V + LG++ + + + D + + + + +G + + +N D + Sbjct: 195 IAGVLNGLGTETHLFVRKHAPLRTFDPLIVETLLEVMNTEGPKLHTESVPKAVIKNADGS 254 Query: 279 VVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKF 338 + + T+ + + L+ A+GR P L G++ + +G + +D N+ Sbjct: 255 LTLQLENGTE------VTVDHLIWAIGREPATDNLNLSVTGVKTNDKGYIEVDKFQNTNV 308 Query: 339 PHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHG--HVNYNNIPSVMYSHPEVAWVGKT 396 I VGD T L A G E L H++Y+NIP+V++SHP + +G T Sbjct: 309 KGIYAVGDNTGVVELTPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIGTIGLT 368 Query: 397 EEQLKEAGIDYKIGKF--PFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEM 454 E Q +E D ++ + F A A T +K++ E+I+G H IG E+ Sbjct: 369 EPQAREKFGDDQVKVYTSSFTAMYSAVTQHRQPCRMKLVCVGAEEKIVGIHGIGFGMDEI 428 Query: 455 IAEAGLALEYGASAEDVARVCHAHPTLSEAF 485 + +A++ GA+ +D HPT +E F Sbjct: 429 LQGFAVAMKMGATKKDFDNTVAIHPTAAEEF 459 >5U1O-A nrPDB Length = 458 Score = 131 bits (329), Expect = 7e-31, Method: Compositional matrix adjust. Identities = 117/448 (26%), Positives = 201/448 (44%), Gaps = 28/448 (6%) Query: 44 KAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIK- 102 +AA G A +E + LGGTC+NVGC+P K + + + + M+ A+ G DV D+K Sbjct: 29 RAAMYGAKVALIEAQ-DLGGTCVNVGCVPKKVMWHGAQIAEAMNLYAEDYGFDV--DVKG 85 Query: 103 INVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKED 162 + + +++ + ++ + + NKV KG F DE + V+G T D Sbjct: 86 FDWSKLVESRQAYIGRIHQSYDRVLGNNKVNVIKGFAKFVDEKTVE---VNGEHYTA--D 140 Query: 163 HILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSV 222 HIL I V + PG E + S G L E PKR+ ++G G I +E+ V Sbjct: 141 HIL----IAVGGRPTIPNIPGAEYG----IDSNGFFDLAEQPKRVAVVGAGYIAVEIAGV 192 Query: 223 YSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEI 282 LG++ + + S D + + ++ +G + + D ++ Sbjct: 193 LHALGTETHLFVRKESPLRSFDPMIIDTLVEVMEAEGPTLHTHSVPKEVVKEADGSLT-- 250 Query: 283 VVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIK 342 E+ + L+ A+GR P + G+ +++G + +D+ + I Sbjct: 251 ----LHLENGESQNVDQLIWAIGRHPATDAINLASTGVATNEKGYIKVDEYQETNVKGIY 306 Query: 343 VVGDVTFGPM-LAHKAEEEGIAAVEML--KTGHGHVNYNNIPSVMYSHPEVAWVGKTEEQ 399 VGD+ G + L A + G E L + ++Y+ +P+V++SHP + +G T ++ Sbjct: 307 CVGDIMEGGIELTPVAVKAGRQLSERLFNNKPNAKMDYDLVPTVVFSHPPIGTIGLTTQE 366 Query: 400 LKEA-GID-YKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAE 457 +E G D K+ F A A T +K++ + E ++G H IG EMI Sbjct: 367 AEEKYGKDNIKVYTSGFTAMYTAVTKHRQPCKMKLVCAGEEETVVGLHGIGFTVDEMIQG 426 Query: 458 AGLALEYGASAEDVARVCHAHPTLSEAF 485 G+A++ GA+ D V HPT SE F Sbjct: 427 FGVAMKMGATKADFDSVVAIHPTGSEEF 454 >6B4O-A nrPDB Length = 452 Score = 129 bits (324), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 132/470 (28%), Positives = 210/470 (44%), Gaps = 35/470 (7%) Query: 25 KSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFH 84 K++D ++IGGG G +A +A G N +E ++GGTC+NVGC+P K + S + Sbjct: 5 KTYDYIVIGGGSGGIASANRAGMHGANVLLIEGN-EIGGTCVNVGCVPKKVMWQASSMME 63 Query: 85 QMHTEAQKRGIDV---NGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSF 141 M + G DV N K V N +K D L G N + G +F Sbjct: 64 MMERDTAGYGFDVEIKNFSFKQLVENREKYID----FLHGAYNRGLDSNNIERIHGYATF 119 Query: 142 EDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPF--PGIEIDEEKIVSSTGALS 199 E I V+G E T +I++ATG PG EE + S G + Sbjct: 120 TGEQTIE---VNGTEYT--------APHILIATGGRPKKLGIPG----EEYALDSNGFFA 164 Query: 200 LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQG 259 L+E+PKR+ +G G I E+ LG++ + S D +++ + ++ G Sbjct: 165 LEEMPKRVVFVGAGYIAAELAGTLHGLGAETHWAFRHERPLRSFDDMLSEKVVERYQEMG 224 Query: 260 LDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIG 319 + + ++ V I E+ E++ + ++ GR+P LG E Sbjct: 225 MQIHPNATPAKIEKTAQNEYV-ITFENG-----ESITTDAVIFGTGRQPNTDQLGLENTK 278 Query: 320 LEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHG--HVNY 377 + +D++G + +D N+ I VGDV L A G E L G +++Y Sbjct: 279 VALDEKGYVKVDKFQNTTQNGIYAVGDVIGKIDLTPVAIAAGRRLSERLFNGQTDLYLDY 338 Query: 378 NNIPSVMYSHPEVAWVGKTEE-QLKEAGID-YKIGKFPFAANSRAKTNQDTEGFVKILID 435 N +P+V+++HP VA +G TE+ L+E G D KI + F A + +K++ Sbjct: 339 NLVPTVVFTHPPVATIGLTEKAALEEYGEDQVKIYRSSFTPMYFALGEYRQKCDMKLICV 398 Query: 436 SKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAF 485 K E+I+G H IG EM+ +A++ GA+ D HPT SE F Sbjct: 399 GKEEKIVGLHGIGIGVDEMLQGFAVAIKMGATKADFDNTVAIHPTGSEEF 448 >5W1J-A nrPDB Length = 584 Score = 128 bits (321), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 117/439 (26%), Positives = 193/439 (43%), Gaps = 27/439 (6%) Query: 61 LGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLT 120 LGGTC+NVGCIP K L++ + L + +A+ G DV+ V + +D + L Sbjct: 146 LGGTCVNVGCIPKK-LMHQAALLNHYMEDAKSFGWDVDKGPHDWVKMVEGIQDH-IHALN 203 Query: 121 GGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTP 180 G V Y G D I+ T +G VK + IIVATG E Sbjct: 204 FGYRSSMMNANVKYLNALGEIVDPHTIKTT---NKQGIVKN---ITTNTIIVATG-ERPR 256 Query: 181 FPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIG 240 +P I +E ++S +L P + +G + LE S +G VTV+ + Sbjct: 257 YPPIPGAKEYGITSDDLFTLDHNPGKTLCVGASYVSLECAGFLSSIGCDVTVM-VRSIFL 315 Query: 241 ASMDGEVAKATQKFLKKQGLDFKLSTKVISAK--RNDDKNVVEIVVEDTKTNKQENLEAE 298 D ++A ++ K G+ F S + D ++ + + + ++ + Sbjct: 316 RGFDQQMAGLISDYIAKYGVKFVRPCVPTSVRCLEEYDPESGKLAIYEVEGKHEDGTPFK 375 Query: 299 ----VLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVT-FGPML 353 +L AVGR P +G + + ++ GR+V+DD+ + P+I +GDV+ G L Sbjct: 376 DTFNTVLFAVGRDPCTTNIGLQNVDVKT-TNGRVVVDDEERTNVPNIYAIGDVSNAGYQL 434 Query: 354 AHKAEEEGIAAVEMLKTGHG-HVNYNNIPSVMYSHPEVAWVGKTEE----QLKEAGIDYK 408 A + G L T +Y N+P+ +++ E +G +EE + E I+ Sbjct: 435 TPLAIQAGKNLARRLYTADDCRTDYTNVPTTVFTPLEYGCIGLSEENAISKFGEDNIEVF 494 Query: 409 IGKF-PFAANSRAKTNQDTEGFVKILIDSKTE-RILGAHIIGPNAGEMIAEAGLALEYGA 466 F P + D + K++I+ + + R++G H+ GPNAGE+ +A+ GA Sbjct: 495 HSYFQPLEWTVPHR--PDNTCYAKLIINKQDDNRVVGFHVFGPNAGEVTQGYAVAMHLGA 552 Query: 467 SAEDVARVCHAHPTLSEAF 485 ED R HPT SE F Sbjct: 553 RKEDFDRTIGIHPTCSETF 571 >4NEW-A nrPDB Length = 492 Score = 127 bits (318), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 127/497 (25%), Positives = 219/497 (44%), Gaps = 52/497 (10%) Query: 25 KSHDVVIIGGGPAGYVAAIKAAQLGFNTACV---------EKRGKLGGTCLNVGCIPSKA 75 K D+V+IG G G AA AA L V LGGTC+NVGC+P K Sbjct: 4 KIFDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGTCVNVGCVPKKL 63 Query: 76 LLNNSHLFHQMHTEAQKRGIDVN-GDIKINVANFQKAKDDAVKQLTGGIELLFKKNK-VT 133 ++ + + E+ G + + ++ N KD+AV + + +F+ + + Sbjct: 64 MVTGAQYMEHLR-ESAGFGWEFDRTTLRAEWKNLIAVKDEAVLNINKSYDEMFRDTEGLE 122 Query: 134 YYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGS--EVTPFPGIEIDEEKI 191 ++ G GS E + + V VKE L+ ++I++A+GS + PGIE Sbjct: 123 FFLGWGSLESKNVVNVRESADPASAVKER--LETEHILLASGSWPHMPNIPGIE----HC 176 Query: 192 VSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKAT 251 +SS A L E P+R+ +GGG I +E +++ ++P+ DG+V Sbjct: 177 ISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFN---------AYKPK-----DGQVTLCY 222 Query: 252 QKFLKKQGLDFKLS---TKVISA-------KRNDDKNVVEIVVEDTKTNKQEN---LEAE 298 + + +G D L TK ++A K N K VE+ + +K+ E+ ++ + Sbjct: 223 RGEMILRGFDHTLREELTKQLTANGIQILTKENPAK--VELNADGSKSVTFESGKKMDFD 280 Query: 299 VLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAE 358 ++++A+GR P L + G+ + K G + +D+ + +I +GDVT ML A Sbjct: 281 LVMMAIGRSPRTKDLQLQNAGVMI-KNGGVQVDEYSRTNVSNIYAIGDVTNRVMLTPVAI 339 Query: 359 EEGIAAVE-MLKTGHGHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAAN 417 E A V+ + T ++ + S ++S P + G EE + + F Sbjct: 340 NEAAALVDTVFGTTPRKTDHTRVASAVFSIPPIGTCGLIEEVASKRYEVVAVYLSSFTPL 399 Query: 418 SRAKTNQDTEGFV-KILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCH 476 + + FV KI+ + +LG H++G NA E+I G+ L+ A D Sbjct: 400 MHKVSGSKYKTFVAKIITNHSDGTVLGVHLLGDNAPEIIQGIGICLKLNAKISDFYNTIG 459 Query: 477 AHPTLSEAFKEANMAAY 493 HPT +E +Y Sbjct: 460 VHPTSAEELCSMRTPSY 476 >1ONF-A nrPDB Length = 500 Score = 123 bits (309), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 125/484 (25%), Positives = 210/484 (43%), Gaps = 69/484 (14%) Query: 52 TACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKA 111 A VEK +LGGTC+NVGC+P K + N + + H + ++ G D N+ + Sbjct: 28 VALVEK-SRLGGTCVNVGCVPKKIMFNAASV-HDILENSRHYGFDTK--FSFNLPLLVER 83 Query: 112 KDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDH------IL 165 +D +++L K+KV Y+G SF E +I + G + +D+ IL Sbjct: 84 RDKYIQRLNNIYRQNLSKDKVDLYEGTASFLSENRILIK---GTKDNNNKDNGPLNEEIL 140 Query: 166 DVKNIIVATGSE--VTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVY 223 + +NI++A G++ P GIE +SS ++KE K++ I+G G I +E+ +V Sbjct: 141 EGRNILIAVGNKPVFPPVKGIE----NTISSDEFFNIKE-SKKIGIVGSGYIAVELINVI 195 Query: 224 SRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIV 283 RLG + +I D V + +KK ++ V+ K+ DKN+ I Sbjct: 196 KRLGIDSYIFARGNRILRKFDESVINVLENDMKKNNINIVTFADVVEIKKVSDKNL-SIH 254 Query: 284 VEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKV 343 + D + + + ++ VGR P L EK+ +E + +V+D+ + +I Sbjct: 255 LSDGRIYEH----FDHVIYCVGRSPDTENLKLEKLNVETN-NNYIVVDENQRTSVNNIYA 309 Query: 344 VGD----------------------------------VTFGPMLAHKAEEEG-IAAVEML 368 VGD + + L A G + A + Sbjct: 310 VGDCCMVKKSKEIEDLNLLKLYNEERYLNKKENVTEDIFYNVQLTPVAINAGRLLADRLF 369 Query: 369 KTGHGHVNYNNIPSVMYSHPEVAWVGKTEEQL-----KEAGIDYKIGKFP--FAANSRAK 421 NY IP+V++SHP + +G +EE KE Y+ KF F + + Sbjct: 370 LKKTRKTNYKLIPTVIFSHPPIGTIGLSEEAAIQIYGKENVKIYE-SKFTNLFFSVYDIE 428 Query: 422 TNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTL 481 + ++K++ K E I G HIIG NA E++ +AL+ A+ +D HPT Sbjct: 429 PELKEKTYLKLVCVGKDELIKGLHIIGLNADEIVQGFAVALKMNATKKDFDETIPIHPTA 488 Query: 482 SEAF 485 +E F Sbjct: 489 AEEF 492 >5V36-A nrPDB Length = 453 Score = 117 bits (294), Expect = 8e-27, Method: Compositional matrix adjust. Identities = 122/474 (25%), Positives = 208/474 (43%), Gaps = 39/474 (8%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHL 82 + K +D ++IGGG G +A +AA G E + ++GGTC+NVGC+P K + + + Sbjct: 4 MTKQYDYIVIGGGSGGIASANRAAMHGAKVILFEGK-QVGGTCVNVGCVPKKVMWYGAQV 62 Query: 83 FHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFE 142 ++ A G DV + ++ + + ++ E F N V G +F Sbjct: 63 AETINNYAADYGFDVTTQ-AFHFDVLKQNRQAYIDRIHDSYERGFDSNGVERVYGYATFV 121 Query: 143 DETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSE--VTPFPGIEIDEEKIVSSTGALSL 200 D + V +H +I++ATG + PG E ++S G L Sbjct: 122 DAHTVEVAG----------EH-YTAPHILIATGGHALLPDIPGSEYG----ITSDGFFEL 166 Query: 201 KEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQG- 259 IPKR ++G G I +E+ + LGS+ + + + D E+ +KK G Sbjct: 167 DAIPKRTAVVGAGYIAVEISGILHALGSETHLFVRRDRPLRKFDKEIVGTLVDEMKKDGP 226 Query: 260 --LDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEK 317 F + +VI +N D N + +++E+ E + L+ A+GR G E Sbjct: 227 HLHTFSVPKEVI---KNTD-NSLTLILEN-----GEEYTVDTLIWAIGRAANTKGFNLEV 277 Query: 318 IGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEML--KTGHGHV 375 G+ +D RG + D N+ + +GDV L A + G E L + Sbjct: 278 TGVTLDSRGFIATDAFENTNVEGLYALGDVNGKLELTPVAVKAGRQLSERLFNHKPQAKM 337 Query: 376 NYNNIPSVMYSHPEVAWVGKTEE----QLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVK 431 +Y ++ +V++SHP + +G +EE Q E + + + F + A T+ +K Sbjct: 338 DYKDVATVIFSHPVIGSIGLSEEAALDQYGEENV--TVYRSTFTSMYTAVTSHRQACKMK 395 Query: 432 ILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAF 485 ++ + E+I+G H IG EMI +A++ GA+ D HPT SE F Sbjct: 396 LVTVGEDEKIVGLHGIGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEF 449 >3Q6J-A nrPDB Length = 523 Score = 105 bits (262), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 106/478 (22%), Positives = 204/478 (42%), Gaps = 56/478 (11%) Query: 25 KSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFH 84 + +D + IGGG AG + +G V++ LGG+C + C+P HLF Sbjct: 42 REYDAIFIGGGAAGRFGSAYLRAMGGRQLIVDRWPFLGGSCPHNACVPH-------HLFS 94 Query: 85 QMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIEL--LFKKNKVTYYKGNGSFE 142 E + + Q D +++ G E+ LF+ + + G +F+ Sbjct: 95 DCAAEL----------MLARTFSGQYWFPDMTEKVVGIKEVVDLFRAGRNGPH-GIMNFQ 143 Query: 143 DETKIRVTPVDGLEGTVKEDH-------ILDVKNIIVATGSE--VTPFPGIE----IDEE 189 + ++ + + V ++H + KN+I+A G+ PG+ D Sbjct: 144 SKEQLNLEYILNCPAKVIDNHTVEAAGKVFKAKNLILAVGAGPGTLDVPGVNAKGVFDHA 203 Query: 190 KIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAK 249 +V E + ++GG +E G ++ G + ++ + D E Sbjct: 204 TLVEELD----YEPGSTVVVVGGSKTAVEYGCFFNATGRRTVMLVRTEPLKLIKDNETRA 259 Query: 250 ATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPY 309 +K+QG++ +S ++ D V+ VV T N + +E + + + +G +P Sbjct: 260 YVLDRMKEQGMEI-ISGSNVTRIEEDANGRVQAVVAMTP-NGEMRIETDFVFLGLGEQPR 317 Query: 310 IAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLK 369 A L A+ +GL++ +G +++++ + P++ VGD+ GPM KA + G A + Sbjct: 318 SAEL-AKILGLDLGPKGEVLVNEYLQTSVPNVYAVGDLIGGPMEMFKARKSGCYAARNVM 376 Query: 370 TGHGHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFP----------FAANSR 419 N P +++H EV+++G EE+ + AG + K P A+ R Sbjct: 377 GEKISYTPKNYPDFLHTHYEVSFLGMGEEEARAAGHEIVTIKMPPDTENGLNVALPASDR 436 Query: 420 ------AKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDV 471 K GF KI+ID+KT ++LGAH +G A + + ++ G + +++ Sbjct: 437 TMLYAFGKGTAHMSGFQKIVIDAKTRKVLGAHHVGYGAKDAFQYLNVLIKQGLTVDEL 494 >3NTA-A nrPDB Length = 574 Score = 67.4 bits (163), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 71/265 (26%), Positives = 111/265 (41%), Gaps = 28/265 (10%) Query: 208 TIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTK 267 T++GGG IGLEM LG K T++E Q+ +D E+A + ++ QG+D +L T Sbjct: 155 TVVGGGFIGLEMMESLHHLGIKTTLLELADQVMTPVDREMAGFAHQAIRDQGVDLRLGTA 214 Query: 268 VISAKRNDDKNVV-EIVVEDT-----------KTNKQENLEAEVLLVAVGRRPYIAGLGA 315 + +V + EDT + E LE ++L++A+G RP A Sbjct: 215 LSEVSYQVQTHVASDAAGEDTAHQHIKGHLSLTLSNGELLETDLLIMAIGVRPETQ--LA 272 Query: 316 EKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVT-----------FGPMLAHKAEEEG-IA 363 GL + + G + ++ + P I VGD P LA A +G +A Sbjct: 273 RDAGLAIGELGGIKVNAMMQTSDPAIYAVGDAVEEQDFVTGQACLVP-LAGPANRQGRMA 331 Query: 364 AVEMLKTGHGHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTN 423 A M + V GK E+QLK+AGI ++ A+++ Sbjct: 332 ADNMFGREERYQGTQGTAICKVFDLAVGATGKNEKQLKQAGIAFEKVYVHTASHASYYPG 391 Query: 424 QDTEGFVKILIDSKTERILGAHIIG 448 + F K+L D I GA +G Sbjct: 392 AEVVSF-KLLFDPVKGTIFGAQAVG 415 >4GCM-A nrPDB Length = 312 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 84/330 (25%), Positives = 129/330 (39%), Gaps = 68/330 (20%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLN---VGCIPSKALLNNSHLFH 84 D+ IIG GPAG AA+ A++ T +E RG GG N V P ++ L Sbjct: 8 DIAIIGAGPAGMTAAVYASRANLKTVMIE-RGIPGGQMANTEEVENFPGFEMITGPDLST 66 Query: 85 QMHTEAQKRG-IDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFED 143 +M A+K G + GDIK S ED Sbjct: 67 KMFEHAKKFGAVYQYGDIK-------------------------------------SVED 89 Query: 144 ETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEI 203 + + +V E L K +I+ATG+E + I + E+ + G Sbjct: 90 KGEYKVINFGNKE--------LTAKAVIIATGAE---YKKIGVPGEQELGGRGVSYCAVC 138 Query: 204 P------KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKK 257 KRL +IGGG +E G+ ++ KVT+V + ++ A + K Sbjct: 139 DGAFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQR-----ILQDRAFKN 193 Query: 258 QGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEK 317 +DF S + S D K V + + TK +E EA+ + + +G +P A + Sbjct: 194 DKIDFIWSHTLKSINEKDGK-VGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPF--KD 250 Query: 318 IGLEVDKRGRLVIDDQFNSKFPHIKVVGDV 347 +G+ D G +V D + P I GDV Sbjct: 251 LGITND-VGYIVTKDDMTTSVPGIFAAGDV 279 >3ICS-A nrPDB Length = 588 Score = 62.4 bits (150), Expect = 5e-10, Method: Compositional matrix adjust. Identities = 80/320 (25%), Positives = 138/320 (43%), Gaps = 58/320 (18%) Query: 204 PKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFK 263 P+ T+IGGG IG+EM G +VT+VE Q+ +D E+A + +K Sbjct: 187 PRHATVIGGGFIGVEMVENLRERGIEVTLVEMANQVMPPIDYEMAAYVHEHMK------- 239 Query: 264 LSTKVISAKRNDDKNVVEIVVEDTKTNKQEN-----------LEAEVLLVAVGRRPYIAG 312 N D VE+V ED +EN ++ ++L++A+G +P Sbjct: 240 ----------NHD---VELVFEDGVDALEENGAVVRLKSGSVIQTDMLILAIGVQP--ES 284 Query: 313 LGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDV-----------TFGPMLAHKAEEEG 361 A+ GL + RG + ++++F + PHI +GD T P LA A +G Sbjct: 285 SLAKGAGLALGVRGTIKVNEKFQTSDPHIYAIGDAIEVKDFVTETETMIP-LAWPANRQG 343 Query: 362 IAAVEMLKTGHGHVNYNNIPSVMYSHPE-----VAWVGKTEEQLKEAGIDYKIGKFPFAA 416 +++ HGH + ++ S + VA G E+ LK I Y++ A Sbjct: 344 RMLADII---HGHTDSLYKGTLGTSVAKVFDLTVATTGLNEKILKRLNIPYEV--VHVQA 398 Query: 417 NSRAKTNQD-TEGFVKILIDSKTERILGAHIIGPNAGEMIAEA-GLALEYGASAEDVARV 474 NS A + T +K++ + + +I GA +G + + + A++ + D+ + Sbjct: 399 NSHAGYYPNATPVLIKLIFNKDSGKIYGAQTLGRDGVDKRMDVIATAIKANLTVLDLPDL 458 Query: 475 CHAH-PTLSEAFKEANMAAY 493 ++ P S A NM Y Sbjct: 459 ELSYAPPYSSAKDPVNMVGY 478 >3CGD-A nrPDB Length = 480 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 70/271 (25%), Positives = 121/271 (44%), Gaps = 22/271 (8%) Query: 187 DEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGE 246 D E+I+ + ++++ TIIGGG IGLEM + LG KV ++E IG DG+ Sbjct: 173 DAERILKTLETNKVEDV----TIIGGGAIGLEMAETFVELGKKVRMIERNDHIGTIYDGD 228 Query: 247 VAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGR 306 +A+ K K ++ + V + K N+ VE V D T K A+++LV+VG Sbjct: 229 MAEYIYKEADKHHIEILTNENVKAFKGNER---VEAVETDKGTYK-----ADLVLVSVGV 280 Query: 307 RPYIAGLGAEKI------GLEVDKRGRLVIDDQFNSK--FPHIKVVGDVTFGPMLAHKAE 358 +P L I +EV+ + + D + + H V+ ++ + A Sbjct: 281 KPNTDFLEGTNIRTNHKGAIEVNAYMQTNVQDVYAAGDCATHYHVIKEIHDHIPIGTTAN 340 Query: 359 EEG-IAAVEMLKTGHGHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAAN 417 ++G +A + ML + + + +A G E++ K I YK K + N Sbjct: 341 KQGRLAGLNMLDKRRAFKGTLGTGIIKFMNLTLARTGLNEKEAKGLHIPYKTVKVD-STN 399 Query: 418 SRAKTNQDTEGFVKILIDSKTERILGAHIIG 448 ++K+L S T+++LG +IG Sbjct: 400 MAGYYPNAKPLYLKLLYRSDTKQLLGGQVIG 430 Score = 31.6 bits (70), Expect = 0.79, Method: Compositional matrix adjust. Identities = 17/45 (37%), Positives = 23/45 (51%) Query: 18 VRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLG 62 ++TL NK DV IIGGG G A +LG +E+ +G Sbjct: 178 LKTLETNKVEDVTIIGGGAIGLEMAETFVELGKKVRMIERNDHIG 222 >5UWY-A nrPDB Length = 308 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 81/336 (24%), Positives = 131/336 (38%), Gaps = 72/336 (21%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCI---PSKALLNNS 80 N +D +IIG GPAG AA+ AA+ + A +E+ G GG N I P ++ Sbjct: 2 NAMYDTLIIGSGPAGMTAALYAARSNLSVAIIEQ-GAPGGQMNNTFDIENYPGYDHISGP 60 Query: 81 HLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGS 140 L +M+ +K ++ I + NF K Sbjct: 61 ELAMKMYEPLEKFNVENIYGIVQKIENFGDYK---------------------------- 92 Query: 141 FEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSE--VTPFPGIEIDEEKIVSSTGAL 198 + ED + K +I+ATG++ V PG E + VS Sbjct: 93 ----------------CVLTEDASYEAKTVIIATGAKYRVLGVPGEEYYTSRGVSYCAVC 136 Query: 199 SLKEI-PKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKK 257 + L ++GGG +E ++ KVTVV + Q+ A QK L+ Sbjct: 137 DGAFFRDQDLLVVGGGDSAVEEAIYLTQFAKKVTVVHRRDQLRA----------QKILQD 186 Query: 258 QGL-----DFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAG 312 + DF + V + ND K V +++E+ KT + + + + VG P + G Sbjct: 187 RAFANDKVDFIWDSVVKEIQGNDIK-VSNVLIENVKTGQVTDHAFGGVFIYVGMNP-VTG 244 Query: 313 LGAEKIGLEV-DKRGRLVIDDQFNSKFPHIKVVGDV 347 + + LE+ D G ++ DD + P I +GDV Sbjct: 245 MVKD---LEITDSEGWIITDDHMRTSIPGIFAIGDV 277 >3IWA-A nrPDB Length = 472 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 68/243 (27%), Positives = 109/243 (44%), Gaps = 38/243 (15%) Query: 134 YYKGNGSFEDETKIRVTPVDGLEGTVK-------EDHILDVKNIIVATGSEVT--PFPGI 184 +++ N E + R +D TV+ E L +++A GS+ P G+ Sbjct: 74 FFRINKDVEALVETRAHAIDRAAHTVEIENLRTGERRTLKYDKLVLALGSKANRPPVEGM 133 Query: 185 EI---------DEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMG-SVYSRLGSKVTVVE 234 ++ DE + V A+S E+ K + I+GGG IGLEM S+ G TVVE Sbjct: 134 DLAGVTPVTNLDEAEFVQH--AISAGEVSKAV-IVGGGFIGLEMAVSLADMWGIDTTVVE 190 Query: 235 FQPQIGASMDGEVAKATQKFLK----KQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTN 290 QI M G +K+ + L+ K + KV+ + + K V V+ D +T Sbjct: 191 LADQI---MPGFTSKSLSQMLRHDLEKNDVVVHTGEKVVRLEGENGK--VARVITDKRT- 244 Query: 291 KQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFG 350 L+A+++++A G P A GLE+D RG +++D + + P I GD Sbjct: 245 ----LDADLVILAAGVSPNTQL--ARDAGLELDPRGAIIVDTRMRTSDPDIFAGGDCVTI 298 Query: 351 PML 353 P L Sbjct: 299 PNL 301 >5MJK-A nrPDB Length = 327 Score = 55.1 bits (131), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 82/335 (24%), Positives = 130/335 (38%), Gaps = 72/335 (21%) Query: 25 KSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCI---PSKALLNNSH 81 K +DVVIIG GPAG AA+ A+ T +E RG GG N I P + Sbjct: 23 KKYDVVIIGSGPAGMTAAMYTARSEMKTLLLE-RGVPGGQMNNTAEIENYPGYETIMGPE 81 Query: 82 LFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSF 141 L +M + G++ N + G Sbjct: 82 LSMKMAEPLEGLGVE---------------------------------NAYGFVTGIEDH 108 Query: 142 EDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGS--EVTPFPGIEIDEEKIVS----ST 195 D KI + ED K+II+ATG+ PG E + VS Sbjct: 109 GDYKKI-----------ITEDDEFITKSIIIATGANHRKLEIPGEEEYGARGVSYCAVCD 157 Query: 196 GALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFL 255 GA + + +IGGG +E +R G VT++ + ++ A E+ + Q+ Sbjct: 158 GAFFRNQ---EILVIGGGDSAVEEALYLTRFGQSVTIMHRRDKLRAQ---EIIQ--QRAF 209 Query: 256 KKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRP---YIAG 312 K++ ++F + + K DDK + +V ++ KT + + + VG P +++ Sbjct: 210 KEEKINFIWDSVPMEIK-GDDKKIQSVVYKNVKTGEVTEKAFGGIFIYVGLDPVAEFVSD 268 Query: 313 LGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDV 347 LG D+ G ++ DD + P I VGDV Sbjct: 269 LGI------TDEAGWIITDDHMRTNIPGIFAVGDV 297 >5JCN-A nrPDB Length = 451 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 45/201 (22%), Positives = 87/201 (43%), Gaps = 23/201 (11%) Query: 206 RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASM-DGEVAKATQKFLKKQGLDFKL 264 + I+GGG IGLE+ + VT+V +P + ++A + + +G+ Sbjct: 182 KAVIVGGGYIGLELSAALKINDFDVTMVFPEPWCMPRLFTADIAAFYESYYTNKGVKIVK 241 Query: 265 STKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDK 324 T + + + +V + +++ LEA++++V VG RP L G ++ Sbjct: 242 GTVAVGFDADANGDVTAVNLKNGSV-----LEADIVVVGVGGRP----LTTLFKGQVAEE 292 Query: 325 RGRLVIDDQFNSKFPHIKVVGDVTFGPML-------------AHKAEEEGIAAVEMLKTG 371 +G + D F + P + VGDV PM A K+ E+ + A++ ++G Sbjct: 293 KGGIKTDAFFETSVPGVYAVGDVATFPMKMYNELRRVEHVDHARKSAEQAVKAIKGKESG 352 Query: 372 HGHVNYNNIPSVMYSHPEVAW 392 V Y+ +P ++ W Sbjct: 353 ESVVEYDYLPYFFSRSFDLGW 373 >1NHQ-A nrPDB Length = 447 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 81/357 (22%), Positives = 151/357 (42%), Gaps = 40/357 (11%) Query: 161 EDHILDVKNIIVATGSEVTPF----PGIEIDEEKIVS-STGALSLKEIP-----KRLTII 210 E+ + + +I++ G+ PF PG ++D ++ A+ LK+ + +I Sbjct: 98 EERVENYDKLIISPGA--VPFELDIPGKDLDNIYLMRGRQWAIKLKQKTVDPEVNNVVVI 155 Query: 211 GGGIIGLEMGSVYSRLGSKVTVVEFQPQ-IGASMDGEVAKATQKFLKKQGLDFKLSTKVI 269 G G IG+E +++ G KVTV++ + +G +D E + ++ + V Sbjct: 156 GSGYIGIEAAEAFAKAGKKVTVIDILDRPLGVYLDKEFTDVLTEEMEANNITIATGETV- 214 Query: 270 SAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLV 329 +R + V+ VV D + +A++++VAVG RP A L K LE+ G + Sbjct: 215 --ERYEGDGRVQKVVTD-----KNAYDADLVVVAVGVRPNTAWL---KGTLELHPNGLIK 264 Query: 330 IDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYSHPE 389 D+ + P + VGD T + + A+ E A+ G N+ + P Sbjct: 265 TDEYMRTSEPDVFAVGDATL--IKYNPADTEVNIALATNARKQGRFAVKNLEEPVKPFPG 322 Query: 390 V---AWVGKTEEQLKEAGID----YKIGK----FPFAANSRAKTNQDTE-GFVKILIDSK 437 V + + + + GI+ K+GK + N D + + K++ D + Sbjct: 323 VQGSSGLAVFDYKFASTGINEVMAQKLGKETKAVTVVEDYLMDFNPDKQKAWFKLVYDPE 382 Query: 438 TERILGAHIIG-PNAGEMIAEAGLALEYGASAEDVARV-CHAHPTLSEAFKEANMAA 492 T +ILGA ++ + I LA++ + ED+A P + + N AA Sbjct: 383 TTQILGAQLMSKADLTANINAISLAIQAKMTIEDLAYADFFFQPAFDKPWNIINTAA 439 >5ER0-A nrPDB Length = 518 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 71/297 (23%), Positives = 125/297 (42%), Gaps = 32/297 (10%) Query: 170 IIVATGSE--VTPFPGIEIDEEKIVSSTG-ALSLKEIPK---RLTIIGGGIIGLEMGSVY 223 +++ +GS V PGI+ D K+ + A +L E K R+T+IG G IG E+ Y Sbjct: 157 LVMTSGSWPIVPKIPGIDSDRVKLCKNWAHAQALIEDAKEAKRITVIGAGYIGAELAEAY 216 Query: 224 SRLGSKVTVVEFQPQIGAS-MDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEI 282 S G VT+++ ++ D + ++ + G+ L V S D + I Sbjct: 217 STTGHDVTLIDAMARVMPKYFDADFTDVIEQDYRDHGVQLALGETVES--FTDSATGLTI 274 Query: 283 VVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIK 342 KT+K + E ++ ++ +G RP L K +++ G ++ DD S P I Sbjct: 275 -----KTDKN-SYETDLAILCIGFRPNTDLL---KGKVDMAPNGAIITDDYMRSSNPDIF 325 Query: 343 VVGD---VTFGPM-------LAHKAEEEGI-AAVEMLKTGHGHVNYNNIPSVMYSHPEVA 391 GD V + P LA A +GI ++K ++ + + + Sbjct: 326 AAGDSAAVHYNPTHQNAYIPLATNAVRQGILVGKNLVKPTVKYMGTQSSSGLALYDRTIV 385 Query: 392 WVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEG-FVKILIDSKTERILGAHII 447 G T K+ G++ + + N R + TE + ++ D T RILG ++ Sbjct: 386 STGLTLAAAKQQGLNAE--QVIVEDNYRPEFMPSTEPVLMSLVFDPDTHRILGGALM 440 >2BC1-A nrPDB Length = 490 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 91/390 (23%), Positives = 152/390 (38%), Gaps = 58/390 (14%) Query: 140 SFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSE--VTPFPGIEIDEEKI------ 191 S + + K VDG ++H+ +I ATGS+ + P G EI E + Sbjct: 117 SIDYDAKTVTALVDG------KNHVETYDKLIFATGSQPILPPIKGAEIKEGSLEFEATL 170 Query: 192 ------------VSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVE-FQPQ 238 L K+I KR+ ++G G IG+E+ + R G +V +++ Sbjct: 171 ENLQFVKLYQNSADVIAKLENKDI-KRVAVVGAGYIGVELAEAFQRKGKEVVLIDVVDTC 229 Query: 239 IGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAE 298 + D ++ K +++ G+ V N VE T+K E + + Sbjct: 230 LAGYYDRDLTDLMAKNMEEHGIQLAFGETVKEVAGNGK-------VEKIITDKNE-YDVD 281 Query: 299 VLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDV----------T 348 ++++AVG RP LG KI L + G +++ + + P + +GD T Sbjct: 282 MVILAVGFRPNTT-LGNGKIDLF--RNGAFLVNKRQETSIPGVYAIGDCATIYDNATRDT 338 Query: 349 FGPMLAHKAEEEGIAAVEML----KTGHGHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAG 404 LA A GI A G G N I S+ H + G T E+ K G Sbjct: 339 NYIALASNAVRTGIVAAHNACGTDLEGIGVQGSNGI-SIYGLH--MVSTGLTLEKAKRLG 395 Query: 405 IDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEM-IAEAGLALE 463 D + ++ + + +KI+ D + RILGA + M I LA++ Sbjct: 396 FDAAVTEYTDNQKPEFIEHGNFPVTIKIVYDKDSRRILGAQMAAREDVSMGIHMFSLAIQ 455 Query: 464 YGASAEDVARV-CHAHPTLSEAFKEANMAA 492 G + E +A P ++ + MAA Sbjct: 456 EGVTIEKLALTDIFFLPHFNKPYNYITMAA 485 >2CDU-A nrPDB Length = 452 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 50/192 (26%), Positives = 87/192 (45%), Gaps = 20/192 (10%) Query: 170 IIVATGSE--VTPFPGIEIDEEKIVSSTGALS--LKEIPK--RLTIIGGGIIGLEMGSVY 223 +I+ TGS+ V P PGI+ + + +E PK +TIIG G IG E+ Y Sbjct: 109 LIMTTGSKPTVPPIPGIDSSRVYLCKNYNDAKKLFEEAPKAKTITIIGSGYIGAELAEAY 168 Query: 224 SRLGSKVTVVEFQPQI-GASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEI 282 S V +++ ++ D E K + G++ L +KV + + DD EI Sbjct: 169 SNQNYNVNLIDGHERVLYKYFDKEFTDILAKDYEAHGVNLVLGSKVAAFEEVDD----EI 224 Query: 283 VVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIK 342 + TKT + +++++ ++ +G RP L + L+ G ++ D+ +S I Sbjct: 225 I---TKTLDGKEIKSDIAILCIGFRPNTELLKGKVAMLD---NGAIITDEYMHSSNRDIF 278 Query: 343 VVGD---VTFGP 351 GD V + P Sbjct: 279 AAGDSAAVHYNP 290 >1Q1R-A nrPDB Length = 431 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 53/233 (22%), Positives = 99/233 (42%), Gaps = 18/233 (7%) Query: 124 ELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFP- 182 E L+ + Y N T++ D + + + LD +++ATG P P Sbjct: 60 ESLYLRTPDAYAAQNIQLLGGTQVTAINRDRQQVILSDGRALDYDRLVLATGGRPRPLPV 119 Query: 183 -----GIEIDEEKIVSSTGALSLKE---IPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVE 234 G + + + A ++ RL +IGGG IGLE+ + + VT+++ Sbjct: 120 ASGAVGKANNFRYLRTLEDAECIRRQLIADNRLVVIGGGYIGLEVAATAIKANMHVTLLD 179 Query: 235 FQPQIGASMDGEVAKATQKFLKKQ-GLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQE 293 ++ + A + L ++ G+D + T+V + + D+ V V+ + T Sbjct: 180 TAARVLERVTAPPVSAFYEHLHREAGVDIRTGTQVCGFEMSTDQQKVTAVLCEDGT---- 235 Query: 294 NLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGD 346 L A++++ +G P A GL+VD +VI++ + P I VGD Sbjct: 236 RLPADLVIAGIGLIPNCE--LASAAGLQVDN--GIVINEHMQTSDPLIMAVGD 284 >2Q7V-A nrPDB Length = 325 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 78/331 (23%), Positives = 130/331 (39%), Gaps = 62/331 (18%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCL------NVGCIPSKALLNNS 80 +DVVIIGGGPAG AAI + +T +EK G GG N P + Sbjct: 9 YDVVIIGGGPAGLTAAIYTGRAQLSTLILEK-GMPGGQIAWSEEVENFPGFPEP--IAGM 65 Query: 81 HLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGS 140 L +MH +A+K G K+ + Q + DA T NG Sbjct: 66 ELAQRMHQQAEKFG------AKVEMDEVQGVQHDATSH----------PYPFTVRGYNGE 109 Query: 141 FEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPF--PGIEIDEEKIVSSTGAL 198 + K +I+ATG++ PG + K VS+ Sbjct: 110 YR------------------------AKAVILATGADPRKLGIPGEDNFWGKGVSTCATC 145 Query: 199 S-LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKK 257 K++ +IGGG +E G ++ +VTV+ + + A+ +VA+A + Sbjct: 146 DGFFYKGKKVVVIGGGDAAVEEGMFLTKFADEVTVIHRRDTLRAN---KVAQA--RAFAN 200 Query: 258 QGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEK 317 + F T V + D +V + + + KT + L + + + +G P A + + Sbjct: 201 PKMKFIWDTAVEEIQGAD--SVSGVKLRNLKTGEVSELATDGVFIFIGHVPNTAFV-KDT 257 Query: 318 IGLEVDKRGRLVIDDQFNSKFPHIKVVGDVT 348 + L D G + + D+ + P + GDV+ Sbjct: 258 VSLRDD--GYVDVRDEIYTNIPMLFAAGDVS 286 >5XHU-A nrPDB Length = 329 Score = 46.2 bits (108), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 79/339 (23%), Positives = 131/339 (38%), Gaps = 72/339 (21%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTC---------LNVGCIPSKALL 77 +DV IIGGGP G A T +E KLGG ++G IP A Sbjct: 3 YDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGGKVSLFFPEKIIRDIGGIPGIA-- 60 Query: 78 NNSHLFHQMHTEAQKRGIDVNGDIKIN--VANFQKAKDDAVKQLTGGIELLFKKNKVTYY 135 L Q+ +A + DI +N V F++ DD LTG V Sbjct: 61 -GKQLIEQLKEQAAT----FDPDIVLNQRVTGFERL-DDGTIVLTGSEGKKHYTRTVILA 114 Query: 136 KGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSST 195 G G+ E V E D ++ G + EK+ + Sbjct: 115 CGMGTLE----------------VNE---FDSEDAARYAGKN------LHYGVEKLDAFK 149 Query: 196 GALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFL 255 G KR+ I GGG ++ + + + VTVV + + G M+ V K Q Sbjct: 150 G--------KRVVISGGGDTAVDWANELEPIAASVTVVHRREEFGG-MESSVTKMKQS-- 198 Query: 256 KKQGLDFKLSTKVISAKR-----NDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYI 310 S +V++ R D++ + + V T++ +++++E + L++ G + + Sbjct: 199 ---------SVRVLTPYRLEQLNGDEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDL 249 Query: 311 AGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTF 349 + + GLE+++ GR+ D + P + V GD F Sbjct: 250 GPM--MEWGLEIEE-GRVKADRHMRTNLPGVFVAGDAAF 285 >2YVG-A nrPDB Length = 408 Score = 45.8 bits (107), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 41/150 (27%), Positives = 72/150 (48%), Gaps = 26/150 (17%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGA-SMDGEVAKATQKFLKKQGLDFK 263 RL I+GGG+IGLE+ + G V++VE QP++ + + +A ++ QG+D + Sbjct: 146 SRLLIVGGGVIGLELAATARTAGVHVSLVETQPRLMSRAAPATLADFVARYHAAQGVDLR 205 Query: 264 LSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVG-----RRPYIAGLGAEKI 318 +R+ +V +V+ D T + A++++V +G AGL + Sbjct: 206 F-------ERSVTGSVDGVVLLDDGT----RIAADMVVVGIGVLANDALARAAGLACDD- 253 Query: 319 GLEVDKRGRLVIDDQFNSKFPHIKVVGDVT 348 G+ VD GR + P + +GDVT Sbjct: 254 GIFVDAYGR--------TTCPDVYALGDVT 275 >3AB1-A nrPDB Length = 360 Score = 45.4 bits (106), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 74/338 (21%), Positives = 131/338 (38%), Gaps = 64/338 (18%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNS------- 80 D+ IIGGGP G AA + + +E +LGG P K + + + Sbjct: 16 DLTIIGGGPTGIFAAFQCGMNNISCRIIESMPQLGGQL--AALYPEKHIYDVAGFPEVPA 73 Query: 81 -HLFHQMHTEAQKRGIDVNGDIKIN--VANFQKAKDDAVKQLTGGIELLFKKNKVTYYKG 137 L + +A++ N D+ +N V + K DD + +++ V G Sbjct: 74 IDLVESLWAQAER----YNPDVVLNETVTKYTKL-DDGTFETRTNTGNVYRSRAVLIAAG 128 Query: 138 NGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGA 197 G+FE ++ +D L G+ ++ A S V F G Sbjct: 129 LGAFEPRKLPQLGNIDHLTGS----------SVYYAVKS-VEDFKG-------------- 163 Query: 198 LSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVV----EFQPQIGASMDGEVAKATQK 253 KR+ I+GGG L+ + + VT+V EFQ G+ A ++ Sbjct: 164 -------KRVVIVGGGDSALDWTVGLIKNAASVTLVHRGHEFQGH------GKTAHEVER 210 Query: 254 FLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGL 313 +D L T+V S + ++ V+ V + + +EA+ LL+ +G + + L Sbjct: 211 ARANGTIDVYLETEVASIEESN--GVLTRVHLRSSDGSKWTVEADRLLILIGFKSNLGPL 268 Query: 314 GAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGP 351 + LE+ + LV+D + + GD+ + P Sbjct: 269 A--RWDLELYENA-LVVDSHMKTSVDGLYAAGDIAYYP 303 >5UTH-A nrPDB Length = 319 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 78/341 (22%), Positives = 132/341 (38%), Gaps = 87/341 (25%) Query: 22 TINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPS----KALL 77 T HDV+IIG GPAGY AAI AA+ E + GG + + + + + Sbjct: 11 TSQTVHDVIIIGSGPAGYTAAIYAARAQLKPLVFEGT-QFGGALMTTTEVENYPGFREGI 69 Query: 78 NNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKD-DAVKQLTGGIELLFKKNKVTYYK 136 L QM +A + G D+ + +D DAV+ Sbjct: 70 TGPELMDQMREQALRFGADL------------RMEDVDAVQ------------------- 98 Query: 137 GNGSFEDETKIRVTPVDGLEGTVKE----DHILDVKNIIVATGSEVTPF--PGIEIDEEK 190 LEG VK D + +I+A G+ PG E Sbjct: 99 ------------------LEGPVKTVVVGDETHQARAVILAMGAAARHLGVPGEEALTGM 140 Query: 191 IVSSTGALS-LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGAS-MDGEVA 248 VS+ + + ++GGG +E + +R VT++ + + AS + E A Sbjct: 141 GVSTCATCDGFFFRDQDIVVVGGGDSAMEEATFLTRFARSVTLIHRRDEFRASKIMLERA 200 Query: 249 KATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRP 308 +A +K + F +T++ + D V + + DT T ++ L+ + VA+G P Sbjct: 201 RANEK------ITFLTNTEITQIE--GDPKVTGVRLRDTVTGEESKLDVTGVFVAIGHDP 252 Query: 309 YIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTF 349 +E + RG++ +DD+ ++KV G T+ Sbjct: 253 R-----SELV------RGQVELDDE-----GYVKVQGRTTY 277 >3LXD-A nrPDB Length = 415 Score = 43.9 bits (102), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 36/135 (26%), Positives = 68/135 (50%), Gaps = 11/135 (8%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGE-VAKATQKFLKKQGLDFK 263 K +IGGG IGLE +V ++ G VT++E P++ A + GE +++ Q + G+D + Sbjct: 153 KNAVVIGGGYIGLEAAAVLTKFGVNVTLLEALPRVLARVAGEALSEFYQAEHRAHGVDLR 212 Query: 264 LSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGL---GAE-KIG 319 + + D V + ++D + A++++V +G P + L GA G Sbjct: 213 -TGAAMDCIEGDGTKVTGVRMQDGSV-----IPADIVIVGIGIVPCVGALISAGASGGNG 266 Query: 320 LEVDKRGRLVIDDQF 334 ++VD+ R + D + Sbjct: 267 VDVDEFCRTSLTDVY 281 >4ZN0-A nrPDB Length = 311 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 70/336 (20%), Positives = 128/336 (38%), Gaps = 65/336 (19%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLN--VGCIPSKALLNNSHLFH 84 +D++IIGGGPAG A I A + G +T +E+ G + V P ++ L Sbjct: 8 YDLIIIGGGPAGLTAGIYAVRYGLDTLILERNEISGQISMADIVENYPGFPSISGLELME 67 Query: 85 QMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDE 144 + T AQ+ G +K + + + K++ +T G+ Sbjct: 68 RFRTHAQEVG------VKTTITEVLSVRSEGTKKI------------ITTDSGD------ 103 Query: 145 TKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIP 204 L+ K +I+ATG+ G+ ++E I ++ + P Sbjct: 104 --------------------LEAKAVIIATGANPKHL-GVPGEKELISKGVSYCAICDGP 142 Query: 205 ----KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLK-KQG 259 K + ++GGG + S++ KV +V + + A A+ Q + Sbjct: 143 FFRNKIVAVVGGGNSAVTDALFLSKVAQKVYLVHRRDHLKA------ARVLQDRVDGTPN 196 Query: 260 LDFKLSTKV--ISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEK 317 ++ L++ V I R K V +I++ED + + L + + VG P E Sbjct: 197 IELILNSHVLEIVGTREGIKKVEKIILEDVNSRETRELSTNGVFIYVGIHP-----NTEF 251 Query: 318 IGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPML 353 + +E D+ G + D + I GD P+ Sbjct: 252 VDVEKDEGGFIKTDRWMETSEKGIYAAGDCRDTPIW 287 >4EMJ-A nrPDB Length = 410 Score = 43.1 bits (100), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 57/230 (24%), Positives = 99/230 (43%), Gaps = 22/230 (9%) Query: 135 YKGNGSFEDETKIRVTPVDGLEGTVKEDH--ILDVKNIIVATGSE--VTPFPGIEIDEEK 190 + G + T VT +D T+ D L I++ATGS PG ++ Sbjct: 66 WYGEARIDMLTGPEVTALDVQTRTISLDDGTTLSADAIVIATGSRARTMALPGSQLPGVV 125 Query: 191 IVSSTGALSL----KEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDG- 245 + + G + + RL I+GGG+IG E+ + +LG VT++E ++ + G Sbjct: 126 TLRTYGDVQVLRDSWTSATRLLIVGGGLIGCEVATTARKLGLSVTILEAGDELLVRVLGR 185 Query: 246 EVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVG 305 + + L + G+ +L T V+ + + + +++ D + + A+ L+ VG Sbjct: 186 RIGAWLRGLLTELGVQVELGTGVVGF--SGEGQLEQVMASDGR-----SFVADSALICVG 238 Query: 306 RRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPH-IKVVGDVTFGPMLA 354 P A A + GL D R VI D + + VGDV P+ A Sbjct: 239 AEP--ADQLARQAGLACD---RGVIVDHCGATLAKGVFAVGDVASWPLRA 283 >3OC4-A nrPDB Length = 452 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 69/310 (22%), Positives = 126/310 (40%), Gaps = 30/310 (9%) Query: 196 GALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVE-FQPQIGASMDGEVAKATQKF 254 A+ L E + + +IG G IG+E ++ V V E + + D E+ QK Sbjct: 139 AAVPLLENSQTVAVIGAGPIGMEAIDFLVKMKKTVHVFESLENLLPKYFDKEMVAEVQKS 198 Query: 255 LKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLG 314 L+KQ + F V+ + + V+E T++QE + + + A+ P +A L Sbjct: 199 LEKQAVIFHFEETVLGIEETANGIVLE-------TSEQE-ISCDSGIFALNLHPQLAYLD 250 Query: 315 AEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDV----------TFGPMLAHKAEEEGIAA 364 +KI +D+ + +D + P++ +GD TF L + A G+ Sbjct: 251 -KKIQRNLDQT--IAVDAYLQTSVPNVFAIGDCISVMNEPVAETFYAPLVNNAVRTGLVV 307 Query: 365 VEMLK-TGHGHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTN 423 L+ H + +A G TE + G+ + A Sbjct: 308 ANNLEEKTHRFIGSLRTMGTKVGDYYLASTGLTETE----GLFFPQTLASIIVRQPAPPL 363 Query: 424 QD-TEGFVKILIDSKTERILGAHIIGP-NAGEMIAEAGLALEYGASAEDVARVCHAH-PT 480 Q TE K++ D T+R+LGA + N E I L+++ G + D+ + + + P+ Sbjct: 364 QHGTEILGKLIYDKVTQRVLGAQLCSKNNCLEKINTLALSIQTGQTLTDLLQKDYFYQPS 423 Query: 481 LSEAFKEANM 490 L+ + N+ Sbjct: 424 LTNIYDITNL 433 >1FL2-A nrPDB Length = 310 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 49/195 (25%), Positives = 86/195 (44%), Gaps = 20/195 (10%) Query: 164 ILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIP------KRLTIIGGGIIGL 217 +L ++IIVATG++ + + + E + G KR+ +IGGG G+ Sbjct: 101 VLKARSIIVATGAK---WRNMNVPGEDQYRTKGVTYCPHCDGPLFKGKRVAVIGGGNSGV 157 Query: 218 EMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDK 277 E + + VT++EF P++ A +V + + LK +D L+ + K D Sbjct: 158 EAAIDLAGIVEHVTLLEFAPEMKAD---QVLQDKLRSLKN--VDIILNAQTTEVK-GDGS 211 Query: 278 NVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGL-GAEKIGLEVDKRGRLVIDDQFNS 336 VV + D + N+E + V +G P L GA +E ++ G ++ID + + Sbjct: 212 KVVGLEYRDRVSGDIHNIELAGIFVQIGLLPNTNWLEGA----VERNRMGEIIIDAKCET 267 Query: 337 KFPHIKVVGDVTFGP 351 + GD T P Sbjct: 268 NVKGVFAAGDCTTVP 282 >4YKF-A nrPDB Length = 521 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 47/194 (24%), Positives = 84/194 (43%), Gaps = 18/194 (9%) Query: 164 ILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIP------KRLTIIGGGIIGL 217 +L ++IIVATG++ + + + E + G KR+ +IGGG G+ Sbjct: 312 VLKARSIIVATGAK---WRNMNVPGEDQYRTKGVTYCPHCDGPLFKGKRVAVIGGGNSGV 368 Query: 218 EMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDK 277 E + + VT++EF P++ A +V + + LK +D L+ + K D Sbjct: 369 EAAIDLAGIVEHVTLLEFAPEMKAD---QVLQDKLRSLKN--VDIILNAQTTEVK-GDGS 422 Query: 278 NVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSK 337 VV + D + N+E + V +G P L +E ++ G ++ID + + Sbjct: 423 KVVGLEYRDRVSGDIHNIELAGIFVQIGLLPNTNWLEG---AVERNRMGEIIIDAKCETN 479 Query: 338 FPHIKVVGDVTFGP 351 + GD T P Sbjct: 480 VKGVFAAGDCTTVP 493 >1YQZ-A nrPDB Length = 438 Score = 40.8 bits (94), Expect = 0.002, Method: Compositional matrix adjust. Identities = 33/143 (23%), Positives = 73/143 (51%), Gaps = 15/143 (10%) Query: 206 RLTIIGGGIIGLE-MGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKL 264 ++ ++G G + LE + ++Y R G T++ +I MD ++ + L K+ + ++L Sbjct: 150 KVLVVGAGYVSLEVLENLYER-GLHPTLIHRSDKINKLMDADMNQPILDELDKREIPYRL 208 Query: 265 STKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDK 324 + ++ + N EI K+ K E+ + +++ VG P + + I L D+ Sbjct: 209 NEEINAINGN------EITF---KSGKVEHYD--MIIEGVGTHPNSKFIESSNIKL--DR 255 Query: 325 RGRLVIDDQFNSKFPHIKVVGDV 347 +G + ++D+F + P+I +GD+ Sbjct: 256 KGFIPVNDKFETNVPNIYAIGDI 278 >3F8P-A nrPDB Length = 323 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 39/142 (27%), Positives = 66/142 (46%), Gaps = 9/142 (6%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLST 266 + +IGGG LE + S +KV ++ + A + T K KK ++F L++ Sbjct: 157 VAVIGGGDSALEGAEILSSYSTKVYLIHRRDTFKAQ---PIYVETVK--KKPNVEFVLNS 211 Query: 267 KVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRG 326 V K DK V ++VVE+ KT + + L + + +G P A+ G+E D G Sbjct: 212 VVKEIK--GDKVVKQVVVENLKTGEIKELNVNGVFIEIGFDPPTDF--AKSNGIETDTNG 267 Query: 327 RLVIDDQFNSKFPHIKVVGDVT 348 + +D+ + P + GD T Sbjct: 268 YIKVDEWMRTSVPGVFAAGDCT 289 >2JB2-A nrPDB Length = 489 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 16/41 (39%), Positives = 25/41 (60%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 + SH VV++GGGPAG +A + + G+ +E R + GG Sbjct: 8 VKGSHSVVVLGGGPAGLCSAFELQKAGYKVTVLEARTRPGG 48 >6GAS-A nrPDB Length = 331 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 71/337 (21%), Positives = 138/337 (40%), Gaps = 70/337 (20%) Query: 25 KSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFH 84 K +D+ IIGGGP G A + +E +LGG P K + + + Sbjct: 8 KVYDITIIGGGPTGLFTAFYGGMRQASVKIIESLPQLGGQL--SALYPEKYIYDVAGF-- 63 Query: 85 QMHTEAQKRGIDVNGDIKINVANF------QKAKDDAVKQLTGGIELLFKKNKVTYYK-- 136 + R ++ ++K + F ++A D KQ G +L+ NK T+Y Sbjct: 64 -----PKVRAQELVDNLKEQMKKFDPTVCLEEAVDTLEKQADGIFKLV--TNKQTHYSKS 116 Query: 137 -----GNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKI 191 GNG+F+ R+ LEGT K + KN+ ++ F G Sbjct: 117 VIITAGNGAFQPR---RLE----LEGTAKYEK----KNLHYFV-DDMNKFAG-------- 156 Query: 192 VSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKAT 251 KR+ + GGG ++ + + KVT+V + + A + Sbjct: 157 -------------KRVVVFGGGDSAVDWTMMLEPIAEKVTIVHRRDKFRAH-----EHSV 198 Query: 252 QKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIA 311 + + + ++ST + + D + ++V++ KT ++ ++ + ++V G +++ Sbjct: 199 ENLMNSRA---EVSTPYVPVELIGDDKIEQVVLQHVKTEEKVIIDVDDVIVNYG---FVS 252 Query: 312 GLGAEK-IGLEVDKRGRLVIDDQFNSKFPHIKVVGDV 347 LG K GL++ K ++++ + + P I GD+ Sbjct: 253 SLGPIKNWGLDIQKNS-ILVNSKMETNIPGIYAAGDI 288 >3RHA-A nrPDB Length = 482 Score = 38.1 bits (87), Expect = 0.009, Method: Compositional matrix adjust. Identities = 17/40 (42%), Positives = 25/40 (62%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 N DVVI+G GP+G AA + + G + A +E R ++GG Sbjct: 5 NLDRDVVIVGAGPSGLTAARELKKAGLSVAVLEARDRVGG 44 >5NA1-A nrPDB Length = 408 Score = 37.7 bits (86), Expect = 0.012, Method: Compositional matrix adjust. Identities = 49/217 (22%), Positives = 93/217 (42%), Gaps = 41/217 (18%) Query: 149 VTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLT 208 V+ G+EG +DH ++N+I T E++ E+K + + + + Sbjct: 118 VSETFGIEGM--KDHAFQIENVI--TARELSRHI-----EDKFANYAASKEKDDNDLSIL 168 Query: 209 IIGGGIIGLE-MGSVYSRLGS------------KVTVVEFQPQIGASMDGEVAKATQKFL 255 + G G G+E +G + R+ K+T VE P++ E+ +L Sbjct: 169 VGGAGFTGVEFLGELTDRIPELCSKYGVDQNKVKITCVEAAPKMLPMFSEELVNHAVSYL 228 Query: 256 KKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGA 315 + +G++FK++T +++ N+ VVE+ E + N G + AG+ Sbjct: 229 EDRGVEFKIATPIVAC--NEKGFVVEVDGEKQQLN-------------AGTSVWAAGVRG 273 Query: 316 EKI---GLEVDKRGRLVIDDQFN-SKFPHIKVVGDVT 348 K+ E KRGR+V + + +I V+GD + Sbjct: 274 SKLMEESFEGVKRGRIVTKQDLTINGYDNIFVIGDCS 310 >1VDC-A nrPDB Length = 333 Score = 37.4 bits (85), Expect = 0.015, Method: Compositional matrix adjust. Identities = 36/145 (24%), Positives = 65/145 (44%), Gaps = 10/145 (6%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKL 264 K L +IGGG +E + ++ GSKV ++ + AS Q+ L +D Sbjct: 160 KPLAVIGGGDSAMEEANFLTKYGSKVYIIHRRDAFRAS-----KIMQQRALSNPKIDVIW 214 Query: 265 STKVISAKRNDDKNVV-EIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVD 323 ++ V+ A + +++V+ + V++ T +L+ L A+G P L G+E+D Sbjct: 215 NSSVVEAYGDGERDVLGGLKVKNVVTGDVSDLKVSGLFFAIGHEPATKFLDG---GVELD 271 Query: 324 KRGRLVIDD-QFNSKFPHIKVVGDV 347 G +V + P + GDV Sbjct: 272 SDGYVVTKPGTTQTSVPGVFAAGDV 296 >2GMH-A nrPDB Length = 584 Score = 37.0 bits (84), Expect = 0.021, Method: Compositional matrix adjust. Identities = 23/77 (29%), Positives = 36/77 (46%), Gaps = 13/77 (16%) Query: 28 DVVIIGGGPAGYVAAIKAAQLG------FNTACVEKRGKLGGTCLNVGCIPSKALLNNSH 81 DVVI+G GPAG AA + QL VEK +G L+ C+ +A Sbjct: 37 DVVIVGAGPAGLSAATRLKQLAAQHEKDLRVCLVEKAAHIGAHTLSGACLDPRA------ 90 Query: 82 LFHQMHTEAQKRGIDVN 98 F ++ + +++G +N Sbjct: 91 -FEELFPDWKEKGAPLN 106 >3D8X-A nrPDB Length = 326 Score = 36.2 bits (82), Expect = 0.030, Method: Compositional matrix adjust. Identities = 39/145 (26%), Positives = 70/145 (48%), Gaps = 13/145 (8%) Query: 170 IIVATGSEV--TPFPGIEIDEEKIVSSTGALSLKEIP----KRLTIIGGGIIGLEMGSVY 223 II+ATG+ PG E +K +S+ A+ +P K L +IGGG E Sbjct: 122 IILATGASAKRMHLPGEETYWQKGISAC-AVCDGAVPIFRNKPLAVIGGGDSACEEAQFL 180 Query: 224 SRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIV 283 ++ GSKV ++ + + AS + ++ K + ++ +T + AK D K + + Sbjct: 181 TKYGSKVFMLVRKDHLRASTIMQ-----KRAEKNEKIEILYNTVALEAK-GDGKLLNALR 234 Query: 284 VEDTKTNKQENLEAEVLLVAVGRRP 308 +++TK N++ +L L A+G P Sbjct: 235 IKNTKKNEETDLPVSGLFYAIGHTP 259 >3FG2-P nrPDB Length = 404 Score = 36.2 bits (82), Expect = 0.038, Method: Compositional matrix adjust. Identities = 35/146 (23%), Positives = 60/146 (41%), Gaps = 11/146 (7%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGAS-MDGEVAKATQKFLKKQGLDFK 263 K + +IG G IGLE + G +V VVE P++ A + E++ G+ Sbjct: 143 KHVVVIGAGFIGLEFAATARAKGLEVDVVELAPRVMARVVTPEISSYFHDRHSGAGIRMH 202 Query: 264 LSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVD 323 + D+ V +V+ D T L ++++V VG P + A + Sbjct: 203 YGVRATEIAAEGDR-VTGVVLSDGNT-----LPCDLVVVGVGVIPNVEIAAAAGLPTAAG 256 Query: 324 KRGRLVIDDQFNSKFPHIKVVGDVTF 349 +++D Q + PHI +GD Sbjct: 257 ----IIVDQQLLTSDPHISAIGDCAL 278 >2A87-A nrPDB Length = 335 Score = 35.8 bits (81), Expect = 0.042, Method: Compositional matrix adjust. Identities = 37/145 (25%), Positives = 62/145 (42%), Gaps = 17/145 (11%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGAS---MDGEVAKATQKFLKKQGLDFK 263 + +IGGG +E + +R VT+V + + AS +D +FL Sbjct: 158 IAVIGGGDSAMEEATFLTRFARSVTLVHRRDEFRASKIMLDRARNNDKIRFLTNH----- 212 Query: 264 LSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVD 323 V++ + D V + V DT T + L + VA+G P +GL E I +VD Sbjct: 213 ---TVVAV--DGDTTVTGLRVRDTNTGAETTLPVTGVFVAIGHEPR-SGLVREAI--DVD 264 Query: 324 KRGRLVIDDQFNS-KFPHIKVVGDV 347 G +++ + S P + GD+ Sbjct: 265 PDGYVLVQGRTTSTSLPGVFAAGDL 289 Score = 33.5 bits (75), Expect = 0.22, Method: Compositional matrix adjust. Identities = 22/75 (29%), Positives = 33/75 (44%), Gaps = 5/75 (6%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNN----SHLF 83 DV++IG GPAGY AA+ AA+ E GG + + + N L Sbjct: 16 DVIVIGSGPAGYTAALYAARAQLAPLVFEGT-SFGGALMTTTDVENYPGFRNGITGPELM 74 Query: 84 HQMHTEAQKRGIDVN 98 +M +A + G D+ Sbjct: 75 DEMREQALRFGADLR 89 >5W4C-A nrPDB Length = 371 Score = 35.8 bits (81), Expect = 0.049, Method: Compositional matrix adjust. Identities = 38/151 (25%), Positives = 65/151 (43%), Gaps = 13/151 (8%) Query: 164 ILDVKNIIVATGSEVTPF--PGIEIDEEKIVSSTGALSLKEIP----KRLTIIGGGIIGL 217 + II+ATG+ PG E + +S+ A+ +P K L +IGGG Sbjct: 137 FMTADTIILATGASAKRLFLPGEETYWQSGISAC-AVCDGAVPIFRQKPLAVIGGGDSAA 195 Query: 218 EMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDK 277 E + ++ GS V V+ + ++ AS K K L L V + + D + Sbjct: 196 EEATYLTKYGSHVYVLVRRDELRAS------KIMAKRLTSHPKVTVLWNTVATEAKGDGE 249 Query: 278 NVVEIVVEDTKTNKQENLEAEVLLVAVGRRP 308 + + +++TKT + +L L A+G P Sbjct: 250 VLTSLTIKNTKTGETGDLPVNGLFYAIGHEP 280 >4MO2-B nrPDB Length = 368 Score = 35.4 bits (80), Expect = 0.054, Method: Compositional matrix adjust. Identities = 14/39 (35%), Positives = 23/39 (58%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTC 65 +D +I+G G G + A +A + G+ VE+R +GG C Sbjct: 2 YDYLIVGSGLFGSIFAYEATEKGYTCLVVEQREHIGGNC 40 >2V3B-A nrPDB Length = 384 Score = 35.4 bits (80), Expect = 0.061, Method: Compositional matrix adjust. Identities = 37/150 (24%), Positives = 65/150 (43%), Gaps = 22/150 (14%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGAS-MDGEVAKATQKFLKKQGLDFK 263 +R+ ++G G+IG E + S G ++ VV Q+ + AKA Q L+ G+ F Sbjct: 146 RRVLLLGAGLIGCEFANDLSSGGYQLDVVAPCEQVMPGLLHPAAAKAVQAGLEGLGVRFH 205 Query: 264 LSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRP-----YIAGLGAEKI 318 L + S K+ + + + E + ++++ AVG RP + AGL Sbjct: 206 LGPVLASLKKAGEG-------LEAHLSDGEVIPCDLVVSAVGLRPRTELAFAAGLAV--- 255 Query: 319 GLEVDKRGRLVIDDQFNSKFPHIKVVGDVT 348 RG +V+D + +I +GD Sbjct: 256 -----NRG-IVVDRSLRTSHANIYALGDCA 279 >3LZX-A nrPDB Length = 332 Score = 35.0 bits (79), Expect = 0.071, Method: Compositional matrix adjust. Identities = 65/320 (20%), Positives = 130/320 (40%), Gaps = 71/320 (22%) Query: 25 KSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFH 84 K +D+ IIGGGP G A + +E +LGG P K + + + Sbjct: 6 KVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGGQL--SALYPEKYIYDVAGF-- 61 Query: 85 QMHTEAQKRGIDVNGDIKINVANF------QKAKDDAVKQLTGGIELLFKKNKVTYYK-- 136 + R ++ ++K +A F ++A + KQ G +L+ N+ T+Y Sbjct: 62 -----PKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFKLV--TNEETHYSKT 114 Query: 137 -----GNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKI 191 GNG+F+ K+ + + EG + D++ F G Sbjct: 115 VIITAGNGAFKPR-KLELENAEQYEGKNLHYFVDDLQK-----------FAG-------- 154 Query: 192 VSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDG-EVAKA 250 +R+ I+GGG ++ + + +V+++ + + A E A Sbjct: 155 -------------RRVAILGGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHA 201 Query: 251 TQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYI 310 ++ + T + A+ + + ++V+E+ K +++E LE + L+V G ++ Sbjct: 202 SK---------VNVLTPFVPAELIGEDKIEQLVLEEVKGDRKEILEIDDLIVNYG---FV 249 Query: 311 AGLGAEK-IGLEVDKRGRLV 329 + LG K GL+++K +V Sbjct: 250 SSLGPIKNWGLDIEKNSIVV 269 >5JFC-L nrPDB Length = 474 Score = 34.7 bits (78), Expect = 0.091, Method: Compositional matrix adjust. Identities = 43/214 (20%), Positives = 93/214 (43%), Gaps = 41/214 (19%) Query: 170 IIVATGS---EVTPFPGIEID----EEKIVSSTGALSLKEIP---------KRLTIIGGG 213 I + TG+ + P+PG+ ++ + ++ + + P KR+ +IGGG Sbjct: 243 IFIGTGAGTPRIYPWPGVNLNGIYSANEFLTRINLMKAYKFPEYDTPIKVGKRVAVIGGG 302 Query: 214 IIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKR 273 ++ RLG++V ++ + + + K +++G+ F +++ KR Sbjct: 303 NTAMDAARSALRLGAEVWILYRR----TRKEMTAREEEIKHAEEEGVKFMF---LVTPKR 355 Query: 274 ---NDDKNVVEIVVEDTKTNKQEN--------------LEAEVLLVAVGRRPYIAGLGAE 316 +++ N+ I +E K + + +E + ++A+G+ P L Sbjct: 356 FIGDENGNLKAIELEKMKLGEPDESGRRRPIPTGETFIMEFDTAIIAIGQTPNKTFLETV 415 Query: 317 KIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFG 350 GL+VD+ GR+V+D+ + P + GD G Sbjct: 416 P-GLKVDEWGRIVVDENLMTSIPGVFAGGDAIRG 448 >1QO8-A nrPDB Length = 566 Score = 34.3 bits (77), Expect = 0.13, Method: Compositional matrix adjust. Identities = 19/54 (35%), Positives = 30/54 (55%) Query: 236 QPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKT 289 +P G S E+ +K K+QG+D +L+++V+ NDD +VV VV T Sbjct: 241 RPHGGKSSGPEIIDTLRKAAKEQGIDTRLNSRVVKLVVNDDHSVVGAVVHGKHT 294 >1I8T-A nrPDB Length = 367 Score = 33.9 bits (76), Expect = 0.15, Method: Compositional matrix adjust. Identities = 17/58 (29%), Positives = 27/58 (46%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFH 84 +D +I+G G G V A + +L +EKR +GG C + +H+FH Sbjct: 2 YDYIIVGSGLFGAVCANELKKLNKKVLVIEKRNHIGGNAYTEDCEGIQIHKYGAHIFH 59 >2VVL-G nrPDB Length = 495 Score = 33.9 bits (76), Expect = 0.17, Method: Compositional matrix adjust. Identities = 21/62 (33%), Positives = 29/62 (46%), Gaps = 3/62 (4%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCL--NVGCIPSKALLNNSHLFHQ 85 DV++IGGG G A GF T +E R ++GG N+ P + H +HQ Sbjct: 41 DVIVIGGGYCGLTATRDLTVAGFKTLLLEARDRIGGRSWSSNIDGYPYEMGGTWVH-WHQ 99 Query: 86 MH 87 H Sbjct: 100 SH 101 >2ZBW-A nrPDB Length = 335 Score = 33.5 bits (75), Expect = 0.21, Method: Compositional matrix adjust. Identities = 37/150 (24%), Positives = 65/150 (43%), Gaps = 13/150 (8%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKL 264 KR+ I+GGG ++ ++T++ +PQ A +A+ K L K + +L Sbjct: 153 KRVLIVGGGDSAVDWALNLLDTARRITLIHRRPQFRAH------EASVKELMKAHEEGRL 206 Query: 265 STKVISAKRN--DDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGA-EKIGLE 321 R D+ V VV +T ++ LE + +L+ G YI LG GL Sbjct: 207 EVLTPYELRRVEGDERVRWAVVFHNQTQEELALEVDAVLILAG---YITKLGPLANWGLA 263 Query: 322 VDKRGRLVIDDQFNSKFPHIKVVGDVTFGP 351 ++K ++ +D + P + GD+ P Sbjct: 264 LEKN-KIKVDTTMATSIPGVYACGDIVTYP 292 >4CBQ-A nrPDB Length = 314 Score = 33.5 bits (75), Expect = 0.23, Method: Compositional matrix adjust. Identities = 26/81 (32%), Positives = 38/81 (46%), Gaps = 12/81 (14%) Query: 27 HDVVIIGGGPAGYVAAIKAAQL--------GFNTACVEKRGKLGGTCL--NVGCIPSKAL 76 HDVVIIG GPA + AAI + GF V G+L T + N P+ Sbjct: 5 HDVVIIGSGPAAHTAAIYLGRSSLKPVMYEGFMAGGVAAGGQLTTTTIIENFPGFPNG-- 62 Query: 77 LNNSHLFHQMHTEAQKRGIDV 97 ++ + L M T+++K G + Sbjct: 63 IDGNELMMNMRTQSEKYGTTI 83 >4YRY-B nrPDB Length = 468 Score = 33.1 bits (74), Expect = 0.25, Method: Compositional matrix adjust. Identities = 17/46 (36%), Positives = 25/46 (54%) Query: 18 VRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 V+ L +K V ++G GPAG AA A++G++ E K GG Sbjct: 132 VKPLAGSKKEKVAVVGSGPAGLTAAADLAKMGYHVDIFEAFHKPGG 177 >5BR7-A nrPDB Length = 393 Score = 33.1 bits (74), Expect = 0.25, Method: Compositional matrix adjust. Identities = 21/60 (35%), Positives = 31/60 (51%), Gaps = 3/60 (5%) Query: 28 DVVIIGGGPAGYVAAIKAA-QLGFNTACVEKRGKLGGTCLNVGCIPSKALLNN--SHLFH 84 D++++G G G A +AA QLG VEKR LGG + + ++ +HLFH Sbjct: 5 DLIVVGSGLFGLTVAERAASQLGKKVLIVEKRSHLGGNAYSEAEPETGIEIHKYGAHLFH 64 >3MJ4-A nrPDB Length = 397 Score = 33.1 bits (74), Expect = 0.26, Method: Compositional matrix adjust. Identities = 28/96 (29%), Positives = 44/96 (45%), Gaps = 11/96 (11%) Query: 1 MLRIRSLLNNKRAFSSTVRTLTIN-----KSHDVVIIGGGPAGYVAAIKAAQLGFNTACV 55 M + S + N+R T +T T N K D +I+G G AG V A + A G V Sbjct: 3 MTDLPSAVTNER----TEQTNTTNEQQESKGFDYLIVGAGFAGSVLAERLASSGQRVLIV 58 Query: 56 EKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQ 91 ++R +GG + C +L + + H HT ++ Sbjct: 59 DRRPHIGGNAYD--CYDDAGVLIHPYGPHIFHTNSK 92 >6BPY-A nrPDB Length = 374 Score = 33.1 bits (74), Expect = 0.29, Method: Compositional matrix adjust. Identities = 42/169 (24%), Positives = 79/169 (46%), Gaps = 19/169 (11%) Query: 170 IIVATGSEVTPF--PGIEIDEEKIVSSTGALSLKEIP----KRLTIIGGGIIGLEMGSVY 223 +I+ATG+ PG E + +S+ A+ +P K L +IGGG E Sbjct: 119 VIIATGANARRLNLPGEETYWQNGISAC-AVCDGAVPIFRNKPLYVIGGGDSAAEEAMFL 177 Query: 224 SRLGSKVTVVEFQPQIGASMDGEVAKATQKFL---KKQGLDFKLSTKVISAKRNDDKNVV 280 ++ GS VTV+ + ++ AS KA K L K + F + ++ + + Sbjct: 178 AKYGSSVTVLVRRDKLRAS------KAMAKRLLAHPKVTVRFNTVATEVLGEKKPNGLMT 231 Query: 281 EIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLV 329 + +++T T ++E ++A L AVG P A + + +++D+ G ++ Sbjct: 232 HLRIKNTVTGEEEIVDANGLFYAVGHDPATALVKGQ---IDLDEDGYII 277 >3ABT-A nrPDB Length = 662 Score = 33.1 bits (74), Expect = 0.31, Method: Compositional matrix adjust. Identities = 15/46 (32%), Positives = 25/46 (54%) Query: 18 VRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 ++ L K+ V+IIG G +G AA + G + +E R ++GG Sbjct: 99 IKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGG 144 >3ISH-A nrPDB Length = 311 Score = 33.1 bits (74), Expect = 0.32, Method: Compositional matrix adjust. Identities = 77/346 (22%), Positives = 132/346 (38%), Gaps = 57/346 (16%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMH 87 D IIGGGPAG A + A + G A + ++G GG Sbjct: 3 DCAIIGGGPAGLSAGLYATRGGVKNAVLFEKGMPGG------------------------ 38 Query: 88 TEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKI 147 + G +I N+ VK++ G++ + + + G E Sbjct: 39 --------QITGSSEIE--NYP-----GVKEVVSGLDFMQPWQEQCFRFGL-KHEMTAVQ 82 Query: 148 RVTPVDGLEGTVKED-HILDVKNIIVATGSEVTPFPGIEIDEE---KIVSSTGALS-LKE 202 RV+ D + ED + K++I+ATG GI+ + E K VS+ Sbjct: 83 RVSKKDSHFVILAEDGKTFEAKSVIIATGGS-PKRTGIKGESEYWGKGVSTCATCDGFFY 141 Query: 203 IPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQI-GASMDGEVAKATQKFLKKQGLD 261 K + ++GGG +E + + KV ++ + A + E AK K ++ Sbjct: 142 KNKEVAVLGGGDTAVEEAIYLANICKKVYLIHRRDGFRCAPITLEHAKNNDK------IE 195 Query: 262 FKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGL- 320 F L+ V+ + D V + +++T TN++ L + VG A L E + Sbjct: 196 F-LTPYVVEEIKGDASGVSSLSIKNTATNEKRELVVPGFFIFVGYDVNNAVLKQEDNSML 254 Query: 321 -EVDKRGRLVIDDQFNSKFPHIKVVGDV-TFGPMLAHKAEEEGIAA 364 + D+ G +V+D + + GD+ F P A +G A Sbjct: 255 CKCDEYGSIVVDFSMKTNVQGLFAAGDIRIFAPKQVVCAASDGATA 300 >1PS9-A nrPDB Length = 671 Score = 32.7 bits (73), Expect = 0.34, Method: Compositional matrix adjust. Identities = 28/104 (26%), Positives = 46/104 (44%), Gaps = 9/104 (8%) Query: 3 RIRSLLNNKRAFSST-VRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKL 61 ++ S L N RA T + L + ++ ++G GPAG AI AA G + ++ Sbjct: 349 KVTSCLVNPRACHETKMPILPAVQKKNLAVVGAGPAGLAFAINAAARGHQVTLFDAHSEI 408 Query: 62 GGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNG-DIKIN 104 GG IP K + ++ +R I+V G +K+N Sbjct: 409 GGQFNIAKQIPGKEEFYETLRYY-------RRMIEVTGVTLKLN 445 >3NIX-A nrPDB Length = 421 Score = 32.7 bits (73), Expect = 0.35, Method: Compositional matrix adjust. Identities = 16/31 (51%), Positives = 20/31 (64%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKR 58 DV++IG GPAG VAA + GF VEK+ Sbjct: 7 DVLVIGAGPAGTVAASLVNKSGFKVKIVEKQ 37 >5L3D-A nrPDB Length = 852 Score = 32.7 bits (73), Expect = 0.37, Method: Compositional matrix adjust. Identities = 15/46 (32%), Positives = 25/46 (54%) Query: 18 VRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 ++ L K+ V+IIG G +G AA + G + +E R ++GG Sbjct: 270 IKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGG 315 >6BWT-A nrPDB Length = 319 Score = 32.7 bits (73), Expect = 0.41, Method: Compositional matrix adjust. Identities = 13/21 (61%), Positives = 17/21 (80%) Query: 27 HDVVIIGGGPAGYVAAIKAAQ 47 H ++I+G GPAGY AAI AA+ Sbjct: 8 HKLIILGSGPAGYTAAIYAAR 28 >5NMX-A nrPDB Length = 425 Score = 32.7 bits (73), Expect = 0.41, Method: Compositional matrix adjust. Identities = 14/36 (38%), Positives = 19/36 (52%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGT 64 V ++G GP+G AA Q GF E+ +GGT Sbjct: 4 VAVLGAGPSGLTAARYLKQAGFEVMVFERYHHVGGT 39 >4FX9-A nrPDB Length = 453 Score = 32.7 bits (73), Expect = 0.42, Method: Compositional matrix adjust. Identities = 74/300 (24%), Positives = 134/300 (44%), Gaps = 47/300 (15%) Query: 197 ALSLKEIPKRLTI-----IGGGIIGLEMGSVYSRLGSKVT-VVEFQPQIGASMDGEVAKA 250 AL+++E ++ + IGGG IG+EM ++ G VT +V + + S D EV Sbjct: 139 ALAIREYMEKYKVENVVIIGGGYIGIEMAEAFAAQGKNVTMIVRGERVLRRSFDKEVTDI 198 Query: 251 TQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYI 310 ++ LKK L + I+ K ++ VE VV D K AE++++A G +P I Sbjct: 199 LEEKLKKH---VNLRLQEITMKIEGEER-VEKVVTDAGEYK-----AELVILATGIKPNI 249 Query: 311 AGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGI-----AAV 365 A+++G+ + + G + +++ + ++ GDV AE + V Sbjct: 250 E--LAKQLGVRIGETGAIWTNEKMQTSVENVYAAGDV---------AETRHVITGRRVWV 298 Query: 366 EMLKTGH--GHVNYNNI-------PSVM------YSHPEVAWVGKTEEQLKEAGIDYKIG 410 + G+ G+V +NI P V+ + E+ G TE + + G D + Sbjct: 299 PLAPAGNKMGYVAGSNIAGKELHFPGVLGTAVTKFMDVEIGKTGLTEMEALKEGYDVRTA 358 Query: 411 KFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAED 470 F A+ E ++K ++D++T R+LG ++G + I A L G + +D Sbjct: 359 -FIKASTRPHYYPGGREIWLKGVVDNETNRLLGVQVVGSDILPRIDTAAAMLMAGFTTKD 417 >3R9U-A nrPDB Length = 315 Score = 32.3 bits (72), Expect = 0.50, Method: Compositional matrix adjust. Identities = 17/40 (42%), Positives = 22/40 (55%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 N DV IIGGGPAG A + A + G + ++G GG Sbjct: 2 NAMLDVAIIGGGPAGLSAGLYATRGGLKNVVMFEKGMPGG 41 >4JNQ-A nrPDB Length = 345 Score = 32.0 bits (71), Expect = 0.57, Method: Compositional matrix adjust. Identities = 27/81 (33%), Positives = 40/81 (49%), Gaps = 5/81 (6%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNT---ACVEKRGKLGGTCLNVGCIPSKA-LLNNSHLFH 84 V++IG GPAGY AAI AA+ A +++ G+L T +V P A + + Sbjct: 29 VIVIGSGPAGYTAAIYAARAMLKPVVIAGLQQGGQLMITT-DVENYPGYAEPVQGPWMME 87 Query: 85 QMHTEAQKRGIDVNGDIKINV 105 QM +A+ G + DI V Sbjct: 88 QMARQAENVGAQIVHDIITEV 108 >6GAR-A nrPDB Length = 349 Score = 32.0 bits (71), Expect = 0.64, Method: Compositional matrix adjust. Identities = 17/51 (33%), Positives = 24/51 (47%), Gaps = 3/51 (5%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLN 78 DV +IGGGPAG +A + T +E LGG + P K + + Sbjct: 8 DVTVIGGGPAGLYSAFYSGLREMRTKIIEFHPHLGG---KIHVYPEKMIWD 55 Score = 32.0 bits (71), Expect = 0.67, Method: Compositional matrix adjust. Identities = 35/118 (29%), Positives = 52/118 (44%), Gaps = 26/118 (22%) Query: 207 LTIIGGGIIGLEMGSVYSRLGS-KVTVVEFQPQIGASMD-----------GEVAKATQKF 254 +T+IGGG GL + YS L + ++EF P +G + G + K Sbjct: 9 VTVIGGGPAGL-YSAFYSGLREMRTKIIEFHPHLGGKIHVYPEKMIWDVGGLLPVTGDKL 67 Query: 255 LK---KQGLDFK----LSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVG 305 ++ +QGL FK L TKV S RN D KT+ E ++ ++VA G Sbjct: 68 IEQLVQQGLTFKPEVVLDTKVESIIRNQDGTFT------LKTSTGEEHFSKTVIVATG 119 >1F6M-A nrPDB Length = 320 Score = 32.0 bits (71), Expect = 0.72, Method: Compositional matrix adjust. Identities = 23/71 (32%), Positives = 31/71 (43%), Gaps = 3/71 (4%) Query: 25 KSHDVVIIGGGPAGYVAAIKAAQLGFNTACV---EKRGKLGGTCLNVGCIPSKALLNNSH 81 K ++I+G GPAGY AA+ AA+ + EK G+L T L Sbjct: 4 KHSKLLILGSGPAGYTAAVYAARANLQPVLITGMEKGGQLTTTTEVENWPGDPNDLTGPL 63 Query: 82 LFHQMHTEAQK 92 L +MH A K Sbjct: 64 LMERMHEHATK 74 >1O5W-A nrPDB Length = 534 Score = 31.6 bits (70), Expect = 0.79, Method: Compositional matrix adjust. Identities = 16/41 (39%), Positives = 23/41 (56%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNV 68 DVV+IGGG +G AA ++ N +E R ++GG V Sbjct: 23 DVVVIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTV 63 >5TWC-A nrPDB Length = 344 Score = 31.6 bits (70), Expect = 0.86, Method: Compositional matrix adjust. Identities = 14/36 (38%), Positives = 21/36 (58%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 DV IIGGGP+G A+ A + ++ + +LGG Sbjct: 3 DVTIIGGGPSGLYASFYAGLRDMSVRLIDVQSELGG 38 Score = 28.1 bits (61), Expect = 8.8, Method: Compositional matrix adjust. Identities = 28/93 (30%), Positives = 44/93 (47%), Gaps = 20/93 (21%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGS-KVTVVEFQPQIGASMD-----------GEVAKATQ 252 K +TIIGGG GL S Y+ L V +++ Q ++G M G K Sbjct: 2 KDVTIIGGGPSGL-YASFYAGLRDMSVRLIDVQSELGGKMRIYPEKIIWDIGGIAPKPCH 60 Query: 253 KFLK---KQGLDFK----LSTKVISAKRNDDKN 278 + LK KQGL FK L+ +V+ ++ +++ Sbjct: 61 EILKDTIKQGLYFKPEVHLNERVVDIRKKAERH 93 >3GG2-A nrPDB Length = 450 Score = 31.2 bits (69), Expect = 0.97, Method: Compositional matrix adjust. Identities = 19/48 (39%), Positives = 27/48 (56%), Gaps = 3/48 (6%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVE-KRGKLGGTCLNVGCIP 72 S D+ ++G G G V+A A+LG N C++ R K+ LN G IP Sbjct: 2 SLDIAVVGIGYVGLVSATCFAELGANVRCIDTDRNKI--EQLNSGTIP 47 >5VJ7-A nrPDB Length = 476 Score = 31.2 bits (69), Expect = 1.1, Method: Compositional matrix adjust. Identities = 17/57 (29%), Positives = 31/57 (54%), Gaps = 1/57 (1%) Query: 294 NLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFG 350 +EA+ +++A+G+ P L L+VD+ GR+V+D+ + P + GD G Sbjct: 394 TVEADTVIIAIGQTPNKV-LWRATPELKVDEWGRIVVDENLMTSIPGVFAGGDAIRG 449 Score = 28.9 bits (63), Expect = 6.1, Method: Compositional matrix adjust. Identities = 14/35 (40%), Positives = 18/35 (51%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 V IIG GPAG A A++G+ E + GG Sbjct: 157 VAIIGAGPAGLTCAADLAKMGYEVTIYEALHQPGG 191 >2BXR-A nrPDB Length = 527 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 15/41 (36%), Positives = 23/41 (56%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNV 68 DVV+IGGG +G AA + G + +E R ++GG + Sbjct: 15 DVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTI 55 >5USX-A nrPDB Length = 319 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 13/31 (41%), Positives = 19/31 (61%) Query: 25 KSHDVVIIGGGPAGYVAAIKAAQLGFNTACV 55 K ++I+G GPAGY AA+ AA+ N + Sbjct: 5 KHSKLLILGSGPAGYTAAVYAARANLNPVLI 35 >6C6P-A nrPDB Length = 458 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 13/26 (50%), Positives = 19/26 (73%) Query: 209 IIGGGIIGLEMGSVYSRLGSKVTVVE 234 I+G G++G + +V SR G KVTV+E Sbjct: 12 IVGAGVLGSALAAVLSRDGRKVTVIE 37 >6CR0-A nrPDB Length = 440 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 14/39 (35%), Positives = 24/39 (61%) Query: 25 KSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 K +D +++G G +G VAA + + G + +E R +LGG Sbjct: 7 KIYDAIVVGAGFSGLVAARELSAQGRSVLIIEARHRLGG 45 >2BRY-A nrPDB Length = 497 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 17/52 (32%), Positives = 25/52 (48%) Query: 10 NKRAFSSTVRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKL 61 +KRA + + +++G GP G AA++ A LG VEKR K Sbjct: 76 DKRASQPVYQQGQACTNTKCLVVGAGPCGLRAAVELALLGARVVLVEKRIKF 127 >4Y4N-A nrPDB Length = 286 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 18/53 (33%), Positives = 29/53 (54%), Gaps = 6/53 (11%) Query: 5 RSLLNNKRAFSSTVRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEK 57 R++L K AF + + + DV I+GGGP+G AA A+ G+ +E+ Sbjct: 37 RAIL--KSAFDMWLDIIDV----DVAIVGGGPSGLTAARYIAKEGYKVVVLER 83 >4TXK-A nrPDB Length = 615 Score = 30.4 bits (67), Expect = 1.9, Method: Compositional matrix adjust. Identities = 17/52 (32%), Positives = 25/52 (48%) Query: 10 NKRAFSSTVRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKL 61 +KRA + + +++G GP G AA++ A LG VEKR K Sbjct: 68 DKRASQPVYQQGQACTNTKCLVVGAGPCGLRAAVELALLGARVVLVEKRIKF 119 >5YGQ-A nrPDB Length = 342 Score = 30.0 bits (66), Expect = 2.1, Method: Compositional matrix adjust. Identities = 14/38 (36%), Positives = 19/38 (50%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTC 65 DV+I+G GP G A + L V+ K+GG C Sbjct: 8 DVLIVGAGPCGLFAVFELGLLDVKAHLVDILDKVGGQC 45 >2CVJ-A nrPDB Length = 180 Score = 29.6 bits (65), Expect = 2.9, Method: Compositional matrix adjust. Identities = 21/76 (27%), Positives = 38/76 (50%), Gaps = 9/76 (11%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVE-KRGKLGGTCLNVGCIPSKALL----NNSHL 82 DV+++GGGP+G AA+ A+ G ++ R K+ G V +P+ L + L Sbjct: 3 DVIVVGGGPSGLSAALFLARAGLKVLVLDGGRSKVKG----VSRVPNYPGLLDEPSGEEL 58 Query: 83 FHQMHTEAQKRGIDVN 98 ++ A++ G +V Sbjct: 59 LRRLEAHARRYGAEVR 74 >5U63-A nrPDB Length = 321 Score = 29.6 bits (65), Expect = 3.0, Method: Compositional matrix adjust. Identities = 13/23 (56%), Positives = 17/23 (73%) Query: 25 KSHDVVIIGGGPAGYVAAIKAAQ 47 K ++I+G GPAGY AAI AA+ Sbjct: 8 KHAKLLILGSGPAGYTAAIYAAR 30 >1REO-A nrPDB Length = 486 Score = 29.6 bits (65), Expect = 3.1, Method: Compositional matrix adjust. Identities = 18/57 (31%), Positives = 28/57 (49%), Gaps = 1/57 (1%) Query: 185 EIDEEKIVS-STGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIG 240 E D E+ + + L PK + ++G G+ GL V S G +VTV+E + G Sbjct: 13 ETDYEEFLEIARNGLKATSNPKHVVVVGAGMSGLSAAYVLSGAGHQVTVLEASERAG 69 >4Y4M-A nrPDB Length = 290 Score = 29.6 bits (65), Expect = 3.2, Method: Compositional matrix adjust. Identities = 13/30 (43%), Positives = 18/30 (60%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEK 57 DVVI+G GP+G A A+ GF +E+ Sbjct: 61 DVVIVGAGPSGLTCARYLAKEGFKVVVLER 90 >5X6R-A nrPDB Length = 420 Score = 29.6 bits (65), Expect = 3.3, Method: Compositional matrix adjust. Identities = 20/80 (25%), Positives = 39/80 (48%), Gaps = 8/80 (10%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLST 266 + IIG G++G +S+ G VT+ +F+ D + K LK ++ +S Sbjct: 31 VAIIGAGLVGCLAALAFSKEGYNVTLYDFR------QDPRLDTTKNKNLK--SINLAISA 82 Query: 267 KVISAKRNDDKNVVEIVVED 286 + I A ++ D + E +++D Sbjct: 83 RGIDALKSIDPDACEHILQD 102 >3KVE-A nrPDB Length = 486 Score = 29.6 bits (65), Expect = 3.5, Method: Compositional matrix adjust. Identities = 14/37 (37%), Positives = 21/37 (56%) Query: 204 PKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIG 240 PK + ++G G+ GL V + G KVTV+E + G Sbjct: 33 PKHVVVVGAGMSGLSAAYVLAGAGHKVTVLEASERAG 69 >1F8S-A nrPDB Length = 498 Score = 29.6 bits (65), Expect = 3.5, Method: Compositional matrix adjust. Identities = 16/47 (34%), Positives = 24/47 (51%) Query: 188 EEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVE 234 EE + + L PK + I+G G+ GL V + G +VTV+E Sbjct: 17 EEFLEIARNGLKATSNPKHVVIVGAGMAGLSAAYVLAGAGHQVTVLE 63 >5EQD-A nrPDB Length = 400 Score = 29.3 bits (64), Expect = 3.9, Method: Compositional matrix adjust. Identities = 15/46 (32%), Positives = 24/46 (52%), Gaps = 1/46 (2%) Query: 207 LTIIGGGIIGLEMGS-VYSRLGSKVTVVEFQPQIGASMDGEVAKAT 251 L ++G G GL + ++LG +V V+E +P IG + E T Sbjct: 7 LFVVGSGFFGLTIAERAATQLGKRVLVIERRPHIGGNAYSEPEPET 52 >4Z2R-A nrPDB Length = 592 Score = 29.3 bits (64), Expect = 4.5, Method: Compositional matrix adjust. Identities = 12/30 (40%), Positives = 19/30 (63%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEK 57 DV+I+G GPAG ++A A LG + + + Sbjct: 14 DVLIVGAGPAGAMSATLLASLGIRSLMINR 43 >4C3X-A nrPDB Length = 530 Score = 28.9 bits (63), Expect = 5.1, Method: Compositional matrix adjust. Identities = 15/43 (34%), Positives = 20/43 (46%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGC 70 DV+++G G A AA G T +EK + GGT G Sbjct: 29 DVLVVGSGGGALTGAYTAAAQGLTTIVLEKTDRFGGTSAYSGA 71 >2TMD-A nrPDB Length = 729 Score = 28.9 bits (63), Expect = 5.2, Method: Compositional matrix adjust. Identities = 21/81 (25%), Positives = 35/81 (43%), Gaps = 5/81 (6%) Query: 11 KRAFSSTVRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGC 70 +R + T NK V+I+G GP+G AA + G+ + K+GG V Sbjct: 375 RRGWHPEKFRQTKNKD-SVLIVGAGPSGSEAARVLMESGYTVHLTDTAEKIGGHLNQVAA 433 Query: 71 IPSKALLNNSHLFHQMHTEAQ 91 +P + +H+ + E Q Sbjct: 434 LPGLGEWS----YHRDYRETQ 450 >1SEZ-A nrPDB Length = 504 Score = 28.9 bits (63), Expect = 5.2, Method: Compositional matrix adjust. Identities = 16/40 (40%), Positives = 19/40 (47%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNV 68 V +IG G +G AA K G N E GK GG +V Sbjct: 16 VAVIGAGVSGLAAAYKLKIHGLNVTVFEAEGKAGGKLRSV 55 >1J10-A nrPDB Length = 516 Score = 28.9 bits (63), Expect = 5.6, Method: Compositional matrix adjust. Identities = 32/126 (25%), Positives = 55/126 (43%), Gaps = 21/126 (16%) Query: 36 PAGY------VAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTE 89 PAGY + A K+A+L C+E K G P ++ L + T Sbjct: 307 PAGYNDYSHLLDAFKSAKLDVTFTCLEMTDK--------GSYPEYSMPKT--LVQNIATL 356 Query: 90 AQKRGIDVNGDIKINVAN---FQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETK 146 A ++GI +NG+ +++ N +++ + A G LL ++ + G F+D Sbjct: 357 ANEKGIVLNGENALSIGNEEEYKRVAEMAFNYNFAGFTLLRYQDVMYNNSLMGKFKD--L 414 Query: 147 IRVTPV 152 + VTPV Sbjct: 415 LGVTPV 420 >4OVI-A nrPDB Length = 542 Score = 28.1 bits (61), Expect = 8.6, Method: Compositional matrix adjust. Identities = 12/38 (31%), Positives = 21/38 (55%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTC 65 DV+++G G +G A + +LG + +E G +GG Sbjct: 18 DVLVVGAGFSGLYALYRLRELGRSVHVIETAGDVGGVW 55 >6MX4-C nrPDB Length = 260 Score = 28.1 bits (61), Expect = 9.5, Method: Compositional matrix adjust. Identities = 19/68 (27%), Positives = 35/68 (51%), Gaps = 4/68 (5%) Query: 320 LEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPM-LAHKAEEEGIAAVEMLKTGHGHVNYN 378 LE DK ++++ Q N + VVG F P+ + + + E +AA+++ K + Y Sbjct: 107 LESDKTFPIMLNGQVNG---YACVVGGRVFKPLHVEGRIDNEQLAAIKLKKASIYDLEYG 163 Query: 379 NIPSVMYS 386 ++P M S Sbjct: 164 DVPQCMKS 171 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1V59-A nrPDB 615 e-176 5J5Z-A nrPDB 526 e-150 1DXL-A nrPDB 519 e-148 3URH-A nrPDB 519 e-147 5U8W-A nrPDB 518 e-147 5TR3-A nrPDB 511 e-145 3LAD-A nrPDB 506 e-143 2YQU-A nrPDB 496 e-141 6BZ0-A nrPDB 496 e-140 6AON-A nrPDB 489 e-138 2QAE-A nrPDB 489 e-138 6N7F-A nrPDB 484 e-137 1GEU-A nrPDB 482 e-136 5VDN-A nrPDB 482 e-136 2WOV-A nrPDB 475 e-134 2R9Z-A nrPDB 472 e-133 1EBD-A nrPDB 472 e-133 2EQ6-A nrPDB 469 e-132 4NEW-A nrPDB 466 e-132 1ZDL-A nrPDB 464 e-131 4JDR-A nrPDB 464 e-131 2YAU-A nrPDB 464 e-131 6DU7-A nrPDB 461 e-130 5U1O-A nrPDB 460 e-130 2AAQ-A nrPDB 459 e-129 1FEC-A nrPDB 459 e-129 2HQM-A nrPDB 457 e-129 5V36-A nrPDB 457 e-129 2X8H-A nrPDB 456 e-128 6B4O-A nrPDB 451 e-127 2CFY-A nrPDB 450 e-127 4KPR-E nrPDB 449 e-126 4LA1-A nrPDB 448 e-126 6CMZ-A nrPDB 442 e-124 2NVK-X nrPDB 441 e-124 1LVL-A nrPDB 432 e-121 3O0H-A nrPDB 427 e-120 4B1B-A nrPDB 425 e-119 5X1Y-B nrPDB 422 e-118 5W1J-A nrPDB 420 e-118 4DNA-A nrPDB 410 e-114 3II4-A nrPDB 401 e-112 1ONF-A nrPDB 399 e-111 1OJT-A nrPDB 385 e-107 5U25-A nrPDB 381 e-106 4YWO-A nrPDB 375 e-104 1ZK7-A nrPDB 355 3e-98 3IC9-A nrPDB 311 6e-85 1XDI-A nrPDB 308 4e-84 3L8K-A nrPDB 302 2e-82 3Q6J-A nrPDB 283 1e-76 2BC1-A nrPDB 221 6e-58 3CGD-A nrPDB 214 9e-56 5ER0-A nrPDB 213 2e-55 3ICS-A nrPDB 209 2e-54 1NHQ-A nrPDB 204 6e-53 3OC4-A nrPDB 203 1e-52 5UWY-A nrPDB 199 3e-51 3NTA-A nrPDB 198 4e-51 5MJK-A nrPDB 198 5e-51 4GCM-A nrPDB 195 4e-50 2CDU-A nrPDB 191 6e-49 4ZN0-A nrPDB 188 4e-48 2Q7V-A nrPDB 178 4e-45 3IWA-A nrPDB 173 1e-43 5UTH-A nrPDB 173 2e-43 3AB1-A nrPDB 165 5e-41 1YQZ-A nrPDB 165 6e-41 3F8P-A nrPDB 160 1e-39 1Q1R-A nrPDB 155 4e-38 5XHU-A nrPDB 149 2e-36 5JCN-A nrPDB 146 2e-35 4YKF-A nrPDB 131 8e-31 3LXD-A nrPDB 126 1e-29 1FL2-A nrPDB 126 2e-29 4EMJ-A nrPDB 124 8e-29 2YVG-A nrPDB 119 4e-27 Sequences not found previously or not previously below threshold: 2A87-A nrPDB 161 6e-40 5U63-A nrPDB 146 2e-35 6BWT-A nrPDB 144 9e-35 5W4C-A nrPDB 143 2e-34 1F6M-A nrPDB 140 1e-33 5USX-A nrPDB 135 6e-32 4FX9-A nrPDB 134 7e-32 4CBQ-A nrPDB 133 1e-31 6BPY-A nrPDB 133 1e-31 3ISH-A nrPDB 132 3e-31 3D8X-A nrPDB 129 2e-30 3LZX-A nrPDB 127 1e-29 2ZBW-A nrPDB 125 7e-29 6GAS-A nrPDB 124 1e-28 5JFC-L nrPDB 121 6e-28 5M5J-A nrPDB 121 8e-28 4YRY-B nrPDB 120 2e-27 1VDC-A nrPDB 118 5e-27 6GAR-A nrPDB 118 6e-27 3FG2-P nrPDB 117 1e-26 5VJ7-A nrPDB 115 6e-26 2V3B-A nrPDB 114 9e-26 3R9U-A nrPDB 113 2e-25 5TWC-A nrPDB 113 2e-25 2WHD-A nrPDB 111 6e-25 4JNQ-A nrPDB 111 9e-25 5YGQ-A nrPDB 108 7e-24 1XHC-A nrPDB 106 2e-23 5KVH-A nrPDB 87 2e-17 3KLJ-A nrPDB 83 2e-16 5MIU-A nrPDB 82 5e-16 2VDC-G nrPDB 82 7e-16 4G74-A nrPDB 75 9e-14 5NA1-A nrPDB 69 4e-12 5JWC-A nrPDB 66 3e-11 4NTC-A nrPDB 66 3e-11 4USR-A nrPDB 65 9e-11 3UP5-A nrPDB 64 2e-10 4C5O-A nrPDB 62 5e-10 4FK1-A nrPDB 62 5e-10 4OVI-A nrPDB 61 1e-09 2TMD-A nrPDB 60 3e-09 1PS9-A nrPDB 58 7e-09 6JDK-A nrPDB 57 2e-08 6A37-A nrPDB 56 3e-08 5NMX-A nrPDB 55 9e-08 2CVJ-A nrPDB 54 2e-07 3H8L-A nrPDB 51 1e-06 2GAG-A nrPDB 50 2e-06 3K30-A nrPDB 50 2e-06 1NAA-A nrPDB 50 3e-06 5J7X-A nrPDB 50 4e-06 5BR7-A nrPDB 49 4e-06 3MJ4-A nrPDB 49 5e-06 6CR0-A nrPDB 49 5e-06 4RG3-A nrPDB 48 7e-06 1Y56-A nrPDB 48 1e-05 6ER9-A nrPDB 48 1e-05 3RHA-A nrPDB 48 1e-05 1I8T-A nrPDB 47 1e-05 2BXR-A nrPDB 47 2e-05 4AP1-A nrPDB 47 2e-05 2JB2-A nrPDB 46 3e-05 1O5W-A nrPDB 46 3e-05 3T14-A nrPDB 46 4e-05 5EQD-A nrPDB 46 4e-05 3KVE-A nrPDB 46 4e-05 2VOU-A nrPDB 46 5e-05 3BHF-A nrPDB 45 6e-05 1REO-A nrPDB 45 8e-05 2VVL-G nrPDB 45 8e-05 1VRQ-A nrPDB 45 1e-04 5KOX-A nrPDB 45 1e-04 4C3X-A nrPDB 44 1e-04 1ZOV-A nrPDB 44 1e-04 1F8S-A nrPDB 44 2e-04 6BRD-A nrPDB 44 2e-04 2GMH-A nrPDB 43 2e-04 3ABT-A nrPDB 43 3e-04 3ATQ-A nrPDB 43 3e-04 6HNS-A nrPDB 43 3e-04 5L3D-A nrPDB 43 3e-04 4MO2-B nrPDB 43 4e-04 4Y4M-A nrPDB 43 4e-04 2UZZ-A nrPDB 42 5e-04 3CP8-A nrPDB 42 6e-04 3NK2-X nrPDB 42 7e-04 4A6N-B nrPDB 42 7e-04 3NIX-A nrPDB 42 7e-04 4DGK-A nrPDB 42 7e-04 3HYW-A nrPDB 42 8e-04 1SEZ-A nrPDB 41 9e-04 4Y4N-A nrPDB 41 0.001 4TLZ-A nrPDB 41 0.001 4RPJ-A nrPDB 41 0.001 3UKH-A nrPDB 41 0.001 5MOG-A nrPDB 41 0.002 3IHG-A nrPDB 40 0.002 2GAG-B nrPDB 40 0.002 1QO8-A nrPDB 40 0.002 4TXK-A nrPDB 40 0.003 2BRY-A nrPDB 40 0.003 5CQF-A nrPDB 40 0.003 2ZXH-A nrPDB 39 0.004 1RP0-A nrPDB 39 0.005 6HRD-A nrPDB 39 0.005 1C0L-A nrPDB 39 0.005 5Z70-A nrPDB 38 0.008 5TUM-A nrPDB 38 0.009 6C6P-A nrPDB 38 0.010 2XVH-A nrPDB 38 0.010 5KXJ-A nrPDB 38 0.010 4MOP-A nrPDB 38 0.011 1X14-A nrPDB 37 0.016 5AYV-A nrPDB 37 0.016 5GSN-A nrPDB 37 0.019 4B68-A nrPDB 37 0.020 5TUF-A nrPDB 37 0.020 4K2X-A nrPDB 37 0.021 4Z2R-A nrPDB 37 0.024 3FPZ-A nrPDB 37 0.024 3KYB-A nrPDB 36 0.025 1KNR-A nrPDB 36 0.026 2E5V-A nrPDB 36 0.027 3BI4-A nrPDB 36 0.031 1KSU-A nrPDB 36 0.031 2VHY-A nrPDB 36 0.032 1FOH-A nrPDB 36 0.034 3G5Q-A nrPDB 36 0.038 3OZ2-A nrPDB 36 0.042 1F14-A nrPDB 36 0.044 5XGV-A nrPDB 36 0.053 6DLL-A nrPDB 35 0.060 6MO6-A nrPDB 35 0.061 4UIR-A nrPDB 35 0.063 3WE0-A nrPDB 35 0.069 4IV9-A nrPDB 35 0.072 3HDH-A nrPDB 35 0.072 3S61-A nrPDB 35 0.073 1DOD-A nrPDB 35 0.098 3LOV-A nrPDB 35 0.11 4H7U-A nrPDB 35 0.12 2GV8-A nrPDB 35 0.12 3COX-A nrPDB 34 0.13 1LTX-R nrPDB 34 0.14 3CP2-A nrPDB 34 0.14 3G05-A nrPDB 34 0.14 3HN2-A nrPDB 34 0.17 6ACQ-A nrPDB 33 0.24 5KNK-B nrPDB 33 0.25 5Y77-A nrPDB 33 0.26 5EZ7-A nrPDB 33 0.27 3L1R-A nrPDB 33 0.27 2DKH-A nrPDB 33 0.28 1GPE-A nrPDB 33 0.30 4MIF-A nrPDB 33 0.32 3SM8-A nrPDB 33 0.33 2BS2-A nrPDB 33 0.34 1UIR-A nrPDB 33 0.35 3GMC-A nrPDB 33 0.35 4IVM-B nrPDB 33 0.37 3IHM-A nrPDB 33 0.39 1LQU-A nrPDB 33 0.41 5X6R-A nrPDB 33 0.41 4YNU-A nrPDB 33 0.42 6J0Z-C nrPDB 33 0.46 3JSK-A nrPDB 32 0.51 3I6D-A nrPDB 32 0.54 4R16-A nrPDB 32 0.55 3Q9T-A nrPDB 32 0.59 4N9X-A nrPDB 32 0.61 4B4O-A nrPDB 32 0.70 4IIN-A nrPDB 32 0.72 4K22-A nrPDB 32 0.73 5ZYN-B nrPDB 32 0.75 2IVE-A nrPDB 32 0.78 5I68-A nrPDB 31 0.84 4UDQ-A nrPDB 31 0.85 2QA2-A nrPDB 31 0.89 3GG2-A nrPDB 31 0.94 2EEZ-A nrPDB 31 0.94 3O31-A nrPDB 31 0.99 1E3J-A nrPDB 31 1.0 1VIM-A nrPDB 31 1.1 6H3G-A nrPDB 31 1.1 4XRR-A nrPDB 31 1.1 3RP7-A nrPDB 31 1.1 2RGJ-A nrPDB 31 1.2 2CDC-A nrPDB 31 1.2 5X68-A nrPDB 31 1.2 4U2L-A nrPDB 31 1.3 1XJ5-A nrPDB 31 1.4 3TF5-A nrPDB 31 1.5 6C87-A nrPDB 31 1.6 5NCC-A nrPDB 31 1.6 3KKJ-A nrPDB 31 1.7 2B76-A nrPDB 31 1.7 2WTB-A nrPDB 30 1.8 3K6J-A nrPDB 30 1.9 3BA1-A nrPDB 30 1.9 1VE9-A nrPDB 30 2.0 5W1A-A nrPDB 30 2.2 4Z25-A nrPDB 30 2.2 3CUK-A nrPDB 30 2.2 4Z44-A nrPDB 30 2.2 3F3S-A nrPDB 30 2.2 4ZCC-A nrPDB 30 2.3 3GFZ-A nrPDB 30 2.4 5L46-A nrPDB 30 2.5 5XMJ-A nrPDB 30 2.6 4X4J-A nrPDB 30 2.6 3IFR-A nrPDB 30 2.7 3LLV-A nrPDB 30 2.8 1XFD-A nrPDB 30 2.8 4P9S-A nrPDB 30 2.9 2CUL-A nrPDB 30 3.3 1QYD-A nrPDB 30 3.4 5EB4-A nrPDB 30 3.4 4DS7-A nrPDB 30 3.5 3OJO-A nrPDB 30 3.6 4CJX-A nrPDB 30 3.6 4G65-A nrPDB 30 3.6 6D9T-A nrPDB 30 3.7 1CLM-A nrPDB 30 3.8 3P1W-A nrPDB 30 3.9 2BK5-A nrPDB 29 4.1 6H65-A nrPDB 29 4.2 2Y0D-A nrPDB 29 4.3 3IP1-A nrPDB 29 4.6 2AP9-A nrPDB 29 4.6 4KUG-A nrPDB 29 5.2 3MOG-A nrPDB 29 5.6 2PA3-A nrPDB 29 5.7 2YFK-A nrPDB 29 6.1 4A7P-A nrPDB 29 6.2 3KYD-B nrPDB 29 6.4 3KYC-B nrPDB 29 6.4 4EIQ-A nrPDB 29 6.5 1LTH-T nrPDB 29 6.5 3RED-A nrPDB 28 7.6 3GDN-A nrPDB 28 7.8 4D3F-A nrPDB 28 7.9 2RIR-A nrPDB 28 9.0 2DQ4-A nrPDB 28 9.8 3HM2-A nrPDB 28 9.8 >1V59-A nrPDB Length = 478 Score = 615 bits (1586), Expect = e-176, Method: Composition-based stats. Identities = 478/478 (100%), Positives = 478/478 (100%) Query: 22 TINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSH 81 TINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSH Sbjct: 1 TINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSH 60 Query: 82 LFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSF 141 LFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSF Sbjct: 61 LFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSF 120 Query: 142 EDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLK 201 EDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLK Sbjct: 121 EDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLK 180 Query: 202 EIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLD 261 EIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLD Sbjct: 181 EIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLD 240 Query: 262 FKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLE 321 FKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLE Sbjct: 241 FKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLE 300 Query: 322 VDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIP 381 VDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIP Sbjct: 301 VDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIP 360 Query: 382 SVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERI 441 SVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERI Sbjct: 361 SVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERI 420 Query: 442 LGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIHC 499 LGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIHC Sbjct: 421 LGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIHC 478 >5J5Z-A nrPDB Length = 496 Score = 526 bits (1355), Expect = e-150, Method: Composition-based stats. Identities = 269/474 (56%), Positives = 351/474 (74%), Gaps = 11/474 (2%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMH 87 DV +IG GP GYVAAIKAAQLGF T C+EK LGGTCLNVGCIPSKALLNNSH +H H Sbjct: 30 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 89 Query: 88 -TEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETK 146 + RGI+++ ++++N+ + K AVK LTGGI LFK+NKV + G G + + Sbjct: 90 GKDFASRGIEMS-EVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQ 148 Query: 147 IRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKR 206 + T DG ++D KNI++ATGSEVTPFPGI IDE+ IVSSTGALSLK++P++ Sbjct: 149 VTATKADGGT------QVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEK 202 Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGA-SMDGEVAKATQKFLKKQGLDFKLS 265 + +IG G+IG+E+GSV+ RLG+ VT VEF +G +D E++K Q+ L+KQG FKL+ Sbjct: 203 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 262 Query: 266 TKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKR 325 TKV A + D + ++ +E K E + +VLLV +GRRP+ LG E++G+E+D R Sbjct: 263 TKVTGATKKSDGKI-DVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPR 321 Query: 326 GRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMY 385 GR+ ++ +F +K P+I +GDV GPMLAHKAE+EGI VE + G H++YN +PSV+Y Sbjct: 322 GRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIY 381 Query: 386 SHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAH 445 +HPEVAWVGK+EEQLKE GI+YK+GKFPFAANSRAKTN DT+G VKIL T+R+LGAH Sbjct: 382 THPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAH 441 Query: 446 IIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAA-YDKAIH 498 I+GP AGEM+ EA LALEYGAS E +ARVCHAHPTLSEAF+EAN+AA + K+I+ Sbjct: 442 ILGPGAGEMVNEAALALEYGASCEVIARVCHAHPTLSEAFREANLAASFGKSIN 495 >1DXL-A nrPDB Length = 470 Score = 519 bits (1338), Expect = e-148, Method: Composition-based stats. Identities = 265/476 (55%), Positives = 354/476 (74%), Gaps = 9/476 (1%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLF 83 + +DVVIIGGGP GYVAAIKAAQLGF T C+EKRG LGGTCLNVGCIPSKALL++SH++ Sbjct: 4 SDENDVVIIGGGPGGYVAAIKAAQLGFKTTCIEKRGALGGTCLNVGCIPSKALLHSSHMY 63 Query: 84 HQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFED 143 H+ G+ V+ +++I++A KD AV LT GIE LFKKNKVTY KG G F Sbjct: 64 HEAKHSFANHGVKVS-NVEIDLAAMMGQKDKAVSNLTRGIEGLFKKNKVTYVKGYGKFVS 122 Query: 144 ETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEI 203 ++I V ++G E+ ++ K+II+ATGS+V PG+ IDE+KIVSSTGAL+L EI Sbjct: 123 PSEISVDTIEG------ENTVVKGKHIIIATGSDVKSLPGVTIDEKKIVSSTGALALSEI 176 Query: 204 PKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFK 263 PK+L +IG G IGLEMGSV+ R+GS+VTVVEF +I +MD E+ K Q+ L+KQG+ FK Sbjct: 177 PKKLVVIGAGYIGLEMGSVWGRIGSEVTVVEFASEIVPTMDAEIRKQFQRSLEKQGMKFK 236 Query: 264 LSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVD 323 L TKV+ + D V++ VE + +Q +EA+V+LV+ GR P+ +GL +KIG+E D Sbjct: 237 LKTKVVGVDTSGDG--VKLTVEPSAGGEQTIIEADVVLVSAGRTPFTSGLNLDKIGVETD 294 Query: 324 KRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSV 383 K GR++++++F++ + +GDV GPMLAHKAEE+G+A VE L GHV+Y+ +P V Sbjct: 295 KLGRILVNERFSTNVSGVYAIGDVIPGPMLAHKAEEDGVACVEYLAGKVGHVDYDKVPGV 354 Query: 384 MYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILG 443 +Y++PEVA VGKTEEQ+KE G++Y++GKFPF ANSRAK + EG VKI+ + +T++ILG Sbjct: 355 VYTNPEVASVGKTEEQVKETGVEYRVGKFPFMANSRAKAIDNAEGLVKIIAEKETDKILG 414 Query: 444 AHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIHC 499 HI+ PNAGE+I EA +AL+Y AS+ED+ARVCHAHPT+SEA KEA MA YDK IH Sbjct: 415 VHIMAPNAGELIHEAAIALQYDASSEDIARVCHAHPTMSEAIKEAAMATYDKPIHI 470 >3URH-A nrPDB Length = 491 Score = 519 bits (1337), Expect = e-147, Method: Composition-based stats. Identities = 244/476 (51%), Positives = 324/476 (68%), Gaps = 11/476 (2%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQ 85 ++D+++IG GP GYV AIKAAQLG A VEKR GGTCLNVGCIPSKALL+ S +FHQ Sbjct: 25 AYDLIVIGSGPGGYVCAIKAAQLGMKVAVVEKRSTYGGTCLNVGCIPSKALLHASEMFHQ 84 Query: 86 MHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDET 145 + G++V + K+N+ KD VK G+ LFKKNK+ ++G G + Sbjct: 85 AQHGLEALGVEV-ANPKLNLQKMMAHKDATVKSNVDGVSFLFKKNKIDGFQGTGKVLGQG 143 Query: 146 KIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIE--IDEEKIVSSTGALSLKEI 203 K+ VT G E+ +L+ KN+++ATGS+V PG+E DE+ IVSSTGAL+L+++ Sbjct: 144 KVSVTNEKG------EEQVLEAKNVVIATGSDVAGIPGVEVAFDEKTIVSSTGALALEKV 197 Query: 204 PKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFK 263 P + ++GGG+IGLE+GSV++RLG+KVTVVEF I MDGEVAK Q+ L KQG+DFK Sbjct: 198 PASMIVVGGGVIGLELGSVWARLGAKVTVVEFLDTILGGMDGEVAKQLQRMLTKQGIDFK 257 Query: 264 LSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVD 323 L KV A ++ D ++ E K + L+AEV+L+A GR+P GLG K G+ +D Sbjct: 258 LGAKVTGAVKSGDGA--KVTFEPVKGGEATTLDAEVVLIATGRKPSTDGLGLAKAGVVLD 315 Query: 324 KRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSV 383 RGR+ ID F + + +GDV GPMLAHKAE+EG+A E++ GHVNY+ IP V Sbjct: 316 SRGRVEIDRHFQTSIAGVYAIGDVVRGPMLAHKAEDEGVAVAEIIAGQAGHVNYDVIPGV 375 Query: 384 MYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILG 443 +Y+ PEVA VGKTEE+LK AG+ YKIGKFPF AN RA+ T+GFVKIL D +T+R+LG Sbjct: 376 VYTQPEVASVGKTEEELKAAGVAYKIGKFPFTANGRARAMLQTDGFVKILADKETDRVLG 435 Query: 444 AHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIHC 499 HIIG AGEMI E + +E+G S+ED+ R CHAHPT+SEA KEA ++ + K IH Sbjct: 436 GHIIGFGAGEMIHEIAVLMEFGGSSEDLGRTCHAHPTMSEAVKEAALSTFFKPIHM 491 >5U8W-A nrPDB Length = 481 Score = 518 bits (1335), Expect = e-147, Method: Composition-based stats. Identities = 211/483 (43%), Positives = 306/483 (63%), Gaps = 17/483 (3%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEK------RGKLGGTCLNVGCIPSKAL 76 +++ DVV+IG GP GYVAAI+AAQLG TAC+EK + LGGTCLNVGCIPSKAL Sbjct: 4 MSQKFDVVVIGAGPGGYVAAIRAAQLGLKTACIEKYIGKEGKVALGGTCLNVGCIPSKAL 63 Query: 77 LNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYK 136 L++S+ +H+ + GI+ G + I+V K + VK LTGGI LFK N VT ++ Sbjct: 64 LDSSYKYHEAKEAFKVHGIEAKG-VTIDVPAMVARKANIVKNLTGGIATLFKANGVTSFE 122 Query: 137 GNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTG 196 G+G ++ VT +DG +L+ +N+I+A+GS P + ++ IV STG Sbjct: 123 GHGKLLANKQVEVTGLDGKT------QVLEAENVIIASGSRPVEIPPAPLTDDIIVDSTG 176 Query: 197 ALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLK 256 AL + +PK+L +IG G+IGLE+GSV++RLG++VTV+E + + D ++AK K L Sbjct: 177 ALEFQAVPKKLGVIGAGVIGLELGSVWARLGAEVTVLEALDKFLPAADEQIAKEALKVLT 236 Query: 257 KQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAE 316 KQGL+ +L +V +++ K V + D ++E + L+VAVGRRP L A Sbjct: 237 KQGLNIRLGARVTASEVK--KKQVTVTFTDANGEQKET--FDKLIVAVGRRPVTTDLLAA 292 Query: 317 KIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVN 376 G+ +D+RG + +DD + P + +GDV G MLAHKA EEG+ E + +N Sbjct: 293 DSGVTLDERGFIYVDDHCKTSVPGVFAIGDVVRGAMLAHKASEEGVMVAERIAGHKAQMN 352 Query: 377 YNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDS 436 Y+ IPSV+Y+HPE+AWVGKTE+ LK G++ +G FPFAA+ RA DT G VK++ D+ Sbjct: 353 YDLIPSVIYTHPEIAWVGKTEQTLKAEGVEVNVGTFPFAASGRAMAANDTTGLVKVIADA 412 Query: 437 KTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKA 496 KT+R+LG H+IGP+A E++ + + +E+G SAED+ + +HPTLSEA EA +A A Sbjct: 413 KTDRVLGVHVIGPSAAELVQQGAIGMEFGTSAEDLGMMVFSHPTLSEALHEAALAVNGHA 472 Query: 497 IHC 499 IH Sbjct: 473 IHI 475 >5TR3-A nrPDB Length = 481 Score = 511 bits (1316), Expect = e-145, Method: Composition-based stats. Identities = 222/483 (45%), Positives = 304/483 (62%), Gaps = 17/483 (3%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRG------KLGGTCLNVGCIPSKAL 76 + + DVV+IG GP GYVAAIKAAQLG TAC+EK LGGTCLNVGCIPSKAL Sbjct: 4 MTQKFDVVVIGAGPGGYVAAIKAAQLGLKTACIEKYTDAEGKLALGGTCLNVGCIPSKAL 63 Query: 77 LNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYK 136 L++S + + GI G++K++VA K VK LTGG+ LFK N VT + Sbjct: 64 LDSSWKYKEAKESFNVHGIS-TGEVKMDVAAMVGRKAGIVKNLTGGVATLFKANGVTSIQ 122 Query: 137 GNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTG 196 G+G K+ VT DG +++ +N+I+A+GS P +D+ IV STG Sbjct: 123 GHGKLLAGKKVEVTKADGTT------EVIEAENVILASGSRPIDIPPAPVDQNVIVDSTG 176 Query: 197 ALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLK 256 AL + +PKRL +IG G+IGLE+GSV++RLG++VTV+E + D V+K QK L Sbjct: 177 ALEFQAVPKRLGVIGAGVIGLELGSVWARLGAEVTVLEALDTFLMAADTAVSKEAQKTLT 236 Query: 257 KQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAE 316 KQGLD KL +V +K N + E+ V T ++ + + L+VAVGRRP L A Sbjct: 237 KQGLDIKLGARVTGSKVNGN----EVEVTYTNAEGEQKITFDKLIVAVGRRPVTTDLLAS 292 Query: 317 KIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVN 376 G+ +D+RG + +DD + P + +GDV G MLAHKA EEGI VE +K +N Sbjct: 293 DSGVTIDERGYIFVDDYCATSVPGVYAIGDVVRGMMLAHKASEEGIMVVERIKGHKAQMN 352 Query: 377 YNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDS 436 Y+ IPSV+Y+HPE+AWVGKTE+ LK G++ +G FPFAA+ RA DT GFVK++ D+ Sbjct: 353 YDLIPSVIYTHPEIAWVGKTEQALKAEGVEVNVGTFPFAASGRAMAANDTGGFVKVIADA 412 Query: 437 KTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKA 496 KT+R+LG H+IGP+A E++ + +A+E+G SAED+ + +HPTLSEA EA +A A Sbjct: 413 KTDRVLGVHVIGPSAAELVQQGAIAMEFGTSAEDLGMMVFSHPTLSEALHEAALAVNGGA 472 Query: 497 IHC 499 IH Sbjct: 473 IHV 475 >3LAD-A nrPDB Length = 476 Score = 506 bits (1303), Expect = e-143, Method: Composition-based stats. Identities = 210/482 (43%), Positives = 301/482 (62%), Gaps = 17/482 (3%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRG------KLGGTCLNVGCIPSKALL 77 ++ DV++IG GP GYVAAIK+AQLG TA +EK LGGTCLNVGCIPSKALL Sbjct: 1 SQKFDVIVIGAGPGGYVAAIKSAQLGLKTALIEKYKGKEGKTALGGTCLNVGCIPSKALL 60 Query: 78 NNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKG 137 ++S+ FH+ H + GI G++ I+V KD V+ LTGG+ L K N VT ++G Sbjct: 61 DSSYKFHEAHESFKLHGIS-TGEVAIDVPTMIARKDQIVRNLTGGVASLIKANGVTLFEG 119 Query: 138 NGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGA 197 +G K+ VT DG +LD +N+I+A+GS+ P +D++ IV STGA Sbjct: 120 HGKLLAGKKVEVTAADG------SSQVLDTENVILASGSKPVEIPPAPVDQDVIVDSTGA 173 Query: 198 LSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKK 257 L + +P +L +IG G+IGLE+GSV++RLG++VTV+E + ++D +VAK QK L K Sbjct: 174 LDFQNVPGKLGVIGAGVIGLELGSVWARLGAEVTVLEAMDKFLPAVDEQVAKEAQKILTK 233 Query: 258 QGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEK 317 QGL L +V + + ++ V+ +++ + L+VAVGRRP L A Sbjct: 234 QGLKILLGARVTGTEVKNK----QVTVKFVDAEGEKSQAFDKLIVAVGRRPVTTDLLAAD 289 Query: 318 IGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNY 377 G+ +D+RG + +DD + P + +GDV G MLAHKA EEG+ E + +NY Sbjct: 290 SGVTLDERGFIYVDDYCATSVPGVYAIGDVVRGAMLAHKASEEGVVVAERIAGHKAQMNY 349 Query: 378 NNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSK 437 + IP+V+Y+HPE+A VGKTE+ LK G+ +G FPFAA+ RA DT GFVK++ D+K Sbjct: 350 DLIPAVIYTHPEIAGVGKTEQALKAEGVAINVGVFPFAASGRAMAANDTAGFVKVIADAK 409 Query: 438 TERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAI 497 T+R+LG H+IGP+A E++ + +A+E+G SAED+ + AHP LSEA EA +A AI Sbjct: 410 TDRVLGVHVIGPSAAELVQQGAIAMEFGTSAEDLGMMVFAHPALSEALHEAALAVSGHAI 469 Query: 498 HC 499 H Sbjct: 470 HV 471 >2YQU-A nrPDB Length = 455 Score = 496 bits (1278), Expect = e-141, Method: Composition-based stats. Identities = 222/474 (46%), Positives = 305/474 (64%), Gaps = 19/474 (4%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQ 85 +D+++IG GP GYVAAI+AAQLG VEK LGGTCL VGCIPSKALL + ++ Sbjct: 1 MYDLLVIGAGPGGYVAAIRAAQLGMKVGVVEKEKALGGTCLRVGCIPSKALLETTERIYE 60 Query: 86 MHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDET 145 G V G +++++ KD V+ T G+E LFKKN + ++G F E Sbjct: 61 AKKGL--LGAKVKG-VELDLPALMAHKDKVVQANTQGVEFLFKKNGIARHQGTARFLSER 117 Query: 146 KIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPK 205 K+ V L+ + I++ATGS P ++D E++V+ST ALS E+PK Sbjct: 118 KVLVEE---------TGEELEARYILIATGSAPLIPPWAQVDYERVVTSTEALSFPEVPK 168 Query: 206 RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLS 265 RL ++GGG+IGLE+G V+ RLG++V V+E+ +I +MD EV++A ++ KKQGL + Sbjct: 169 RLIVVGGGVIGLELGVVWHRLGAEVIVLEYMDRILPTMDLEVSRAAERVFKKQGLTIRTG 228 Query: 266 TKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKR 325 +V + VE+ E LEA+ +LVAVGRRPY GL E GL D+R Sbjct: 229 VRVTAVVPEAKGARVEL-------EGGEVLEADRVLVAVGRRPYTEGLSLENAGLSTDER 281 Query: 326 GRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMY 385 GR+ +D+ ++ PHI +GDV GPMLAHKA EEGIAAVE + G GHV+Y IPSV+Y Sbjct: 282 GRIPVDEHLRTRVPHIYAIGDVVRGPMLAHKASEEGIAAVEHMVRGFGHVDYQAIPSVVY 341 Query: 386 SHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAH 445 +HPE+A VG TEE+LK GI YK+GKFP++A+ RA+ +TEGF+K+L +KT+RILG H Sbjct: 342 THPEIAAVGYTEEELKAQGIPYKVGKFPYSASGRARAMGETEGFIKVLAHAKTDRILGVH 401 Query: 446 IIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIHC 499 IG G+++AEA LAL + ASAED+ R HAHP+LSE KEA +AA+++ IH Sbjct: 402 GIGARVGDVLAEAALALFFKASAEDLGRAPHAHPSLSEILKEAALAAWERPIHL 455 >6BZ0-A nrPDB Length = 480 Score = 496 bits (1277), Expect = e-140, Method: Composition-based stats. Identities = 208/482 (43%), Positives = 291/482 (60%), Gaps = 16/482 (3%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKR-----GKLGGTCLNVGCIPSKALL 77 +++ D+V+IGGGP GY AAI+AAQLGF AC+EKR LGGTCLNVGCIPSKALL Sbjct: 4 MSQQFDLVVIGGGPGGYEAAIRAAQLGFKVACIEKRIHNGKPSLGGTCLNVGCIPSKALL 63 Query: 78 NNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKG 137 ++SH + GI G++ ++A KD V QLTGGI+ L K N + + KG Sbjct: 64 DSSHRYEDTVHHLADHGI-TTGEVNFDLAKLLARKDKIVDQLTGGIDQLLKGNGIEWLKG 122 Query: 138 NGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGA 197 G K+ P +G E IL+ K +I+A+GS P +D++ IV STGA Sbjct: 123 TGKLLAGKKVEFVPHEG------ETQILEPKYVILASGSVPVNIPVAPVDQDIIVDSTGA 176 Query: 198 LSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKK 257 L+ E+PKRL +IG G+IGLE+GSV+ RLG++V V E D ++K QK L K Sbjct: 177 LNFPEVPKRLGVIGAGVIGLELGSVWRRLGAEVVVFEAMDAFLPMADKALSKEYQKILTK 236 Query: 258 QGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEK 317 QGLD ++ KV + N E+ V+ T+ + + + L+V VGR+ Y GL AE Sbjct: 237 QGLDIRIGAKVSGTEVNGR----EVTVKYTQAGEDKEQTFDKLIVCVGRKAYAEGLLAED 292 Query: 318 IGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNY 377 G+++ +RG + ++D + + +GD+ GPMLAHKA EEG+ AVE + VNY Sbjct: 293 SGIKLTERGLVEVNDHCATSVEGVYAIGDLVRGPMLAHKAMEEGVMAVERIHGHAAQVNY 352 Query: 378 NNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSK 437 + I S++Y+HPE AWVG TEEQ KE G + K G+F FA N RA + GFVK + D+K Sbjct: 353 DTIISIIYTHPEAAWVGLTEEQAKEKGHEVKTGQFGFAVNGRALAAGEGAGFVKFVADAK 412 Query: 438 TERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAI 497 T+R+LG H+IGP A +++ + +ALE+ +S ED+ + HPT SE EA +A +AI Sbjct: 413 TDRLLGMHVIGPAASDIVHQGMIALEFVSSVEDLQLMTFGHPTFSEVVHEAALAVDGRAI 472 Query: 498 HC 499 H Sbjct: 473 HA 474 >6AON-A nrPDB Length = 478 Score = 489 bits (1259), Expect = e-138, Method: Composition-based stats. Identities = 222/482 (46%), Positives = 310/482 (64%), Gaps = 14/482 (2%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKR------GKLGGTCLNVGCIPSKAL 76 ++K DVV+IG GP GY+AAI+AAQLG + AC++ GGTC NVGCIPSKAL Sbjct: 4 MSKQFDVVVIGAGPGGYIAAIRAAQLGMSVACIDAWQNGQGGPAPGGTCTNVGCIPSKAL 63 Query: 77 LNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYK 136 L +S + Q + + GI+V G + + + K+ VKQ GI LFKKNKVTY+ Sbjct: 64 LQSSEHYEQANHHFAEHGIEVKG-VSLKLDTLIGRKNTVVKQNNDGILYLFKKNKVTYFH 122 Query: 137 GNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTG 196 G G+F +V ++ T D L K++IVATGS PG+ DE+ I+S+ G Sbjct: 123 GKGAFAG----QVDGGWSIKVTGTTDADLVAKHVIVATGSSARELPGLPFDEKNILSNDG 178 Query: 197 ALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLK 256 AL++ +PK+L +IG G+IGLEMGSV+ RLG++VT++E P+ A+ D +VAK K Sbjct: 179 ALNIGAVPKKLGVIGAGVIGLEMGSVWRRLGAEVTILEAMPEFLAAADQQVAKEALKSFA 238 Query: 257 KQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAE 316 KQGLD + K+ K + + D K ++ L + L+V++GR PY GL AE Sbjct: 239 KQGLDIQTGVKIGEIK--AAAKSITVPYVDAK-GAEQKLVVDKLIVSIGRVPYTGGLNAE 295 Query: 317 KIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVN 376 +GL++D+RG + +D+ + P++ VGDV GPMLAHKAEEEG+A E + HGHVN Sbjct: 296 AVGLKLDERGFVAVDEDCKTNLPNVWAVGDVVRGPMLAHKAEEEGVAVAERIAGQHGHVN 355 Query: 377 YNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDS 436 + +P V+Y+ PE+AWVGKTE+QLK G +YK G FPF AN RA+ DT GF K++ D+ Sbjct: 356 FATVPWVIYTSPEIAWVGKTEQQLKAEGREYKAGSFPFMANGRARALGDTTGFAKVIADA 415 Query: 437 KTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKA 496 KT+ +LG HIIGP A E+I+EA +E+ +AED+AR+CHAHPTLSEA KEA +A + Sbjct: 416 KTDEVLGVHIIGPMASELISEAVTIMEFRGAAEDIARICHAHPTLSEAVKEAALAVDKRT 475 Query: 497 IH 498 ++ Sbjct: 476 LN 477 >2QAE-A nrPDB Length = 468 Score = 489 bits (1258), Expect = e-138, Method: Composition-based stats. Identities = 244/460 (53%), Positives = 320/460 (69%), Gaps = 11/460 (2%) Query: 41 AAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGD 100 A+IKAAQLG TACVEKRG LGGTCLNVGCIPSKALL+ +HL+H H + G+ Sbjct: 17 ASIKAAQLGMKTACVEKRGALGGTCLNVGCIPSKALLHATHLYHDAHANFARYGLMGGEG 76 Query: 101 IKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVK 160 + ++ A Q+ K+ AVK LTGG+E LFKKNKVTYYKG GSFE IRV +DG + Sbjct: 77 VTMDSAKMQQQKERAVKGLTGGVEYLFKKNKVTYYKGEGSFETAHSIRVNGLDGKQ---- 132 Query: 161 EDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMG 220 +L+ K I+ATGSE T P + DE+ ++SSTGAL+L +PK + +IGGG+IGLE+G Sbjct: 133 --EMLETKKTIIATGSEPTELPFLPFDEKVVLSSTGALALPRVPKTMVVIGGGVIGLELG 190 Query: 221 SVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFL-KKQGLDFKLSTKVISAKRNDDKNV 279 SV++RLG++VTVVEF P+ ++D +V A L K + + F STKV+ N D Sbjct: 191 SVWARLGAEVTVVEFAPRCAPTLDEDVTNALVGALAKNEKMKFMTSTKVVGGTNNGDSVS 250 Query: 280 VEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFP 339 +E+ + K K+E + E LLV+VGRRP+ GLG +KI + ++RG + I D F + P Sbjct: 251 LEV---EGKNGKRETVTCEALLVSVGRRPFTGGLGLDKINVAKNERGFVKIGDHFETSIP 307 Query: 340 HIKVVGDVTF-GPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYSHPEVAWVGKTEE 398 + +GDV GPMLAHKAE+EG+A E+L GHVNY IP+V+Y+ PEVA VGK+E+ Sbjct: 308 DVYAIGDVVDKGPMLAHKAEDEGVACAEILAGKPGHVNYGVIPAVIYTMPEVASVGKSED 367 Query: 399 QLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAEA 458 +LK+ G+ YK+GKFPF ANSRAK +GFVK+L+D T+RILG HI+ AGE+I EA Sbjct: 368 ELKKEGVAYKVGKFPFNANSRAKAVSTEDGFVKVLVDKATDRILGVHIVCTTAGELIGEA 427 Query: 459 GLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIH 498 LA+EYGAS+EDV R CHAHPT+SEA KEA MA + K I+ Sbjct: 428 CLAMEYGASSEDVGRTCHAHPTMSEALKEACMALFAKTIN 467 >6N7F-A nrPDB Length = 453 Score = 484 bits (1247), Expect = e-137, Method: Composition-based stats. Identities = 124/467 (26%), Positives = 210/467 (44%), Gaps = 25/467 (5%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQM 86 +D ++IGGG AG +A +AA G E + ++GGTC+N+GC+P K + + + + Sbjct: 8 YDYIVIGGGSAGIASANRAAMHGAKVLLAEGK-EIGGTCVNLGCVPKKVMWYGAQVADIL 66 Query: 87 HTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETK 146 T A+ G D + + + + ++ E F++N V F+D Sbjct: 67 GTYAKDYGFDFKEK-AFDFKQLKANRQAYIDRIHASYERGFEQNGVDRIYDYAVFKDAHT 125 Query: 147 IRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKR 206 + + + +I++ATG FP IE + +SS G +L E+PKR Sbjct: 126 VEI-----------AGQLYTAPHILIATGGHPV-FPDIEGAQ-YGISSDGFFALDEVPKR 172 Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLST 266 ++G G I +E+ V LGSK + + S D + + G Sbjct: 173 TAVVGAGYIAVELAGVLHALGSKTDLFIRHDRPLRSFDKTIVDVLVDEMAVNGPRLHTHA 232 Query: 267 KVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRG 326 +V +N D++ + + ++D + +E + L+ A+GR+P + G +K G+ ++ +G Sbjct: 233 EVAKVVKNTDES-LTLYLKDG-----QEVEVDQLIWAIGRKPNLEGFSLDKTGVTLNDKG 286 Query: 327 RLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHG--HVNYNNIPSVM 384 + D N+ I VGDV L A G E L G ++Y N+ +V+ Sbjct: 287 YIETDAYENTSVKGIYAVGDVNGKLALTPVAVAAGRRLSERLFNGKTDEKLDYQNVATVI 346 Query: 385 YSHPEVAWVGKTEEQL-KEAGID-YKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERIL 442 +SHP + VG +EE K+ G + K + F + A TN +K++ TE+I+ Sbjct: 347 FSHPVIGSVGLSEEAAVKQYGQEAVKTYQSRFTSMFTAITNHRQPCLMKLVTVGDTEKIV 406 Query: 443 GAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEAN 489 G H IG EMI +A++ GA+ D HPT SE F Sbjct: 407 GLHGIGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR 453 >1GEU-A nrPDB Length = 450 Score = 482 bits (1241), Expect = e-136, Method: Composition-based stats. Identities = 129/473 (27%), Positives = 216/473 (45%), Gaps = 29/473 (6%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHL 82 + K +D + IGGG G + +AA G A +E + +LGGTC+NVGC+P K + + + + Sbjct: 1 MTKHYDYIAIGGGSGGIASINRAAMYGQKCALIEAK-ELGGTCVNVGCVPKKVMWHAAQI 59 Query: 83 FHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFE 142 +H G D + K N ++ + ++ E + KN V KG F Sbjct: 60 REAIHMYGPDYGFDTTIN-KFNWETLIASRTAYIDRIHTSYENVLGKNNVDVIKGFARFV 118 Query: 143 DETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEV--TPFPGIEIDEEKIVSSTGALSL 200 D + V + +I++ATG PG+E + S G +L Sbjct: 119 DAKTLEVN-----------GETITADHILIATGGRPSHPDIPGVE----YGIDSDGFFAL 163 Query: 201 KEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGL 260 +P+R+ ++G G IG+E+G V + LG+K + E S D +++ + + +G Sbjct: 164 PALPERVAVVGAGYIGVELGGVINGLGAKTHLFEMFDAPLPSFDPMISETLVEVMNAEGP 223 Query: 261 DFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGL 320 + + +N D + + + +ED ++ + L+ A+GR P + E G+ Sbjct: 224 QLHTNAIPKAVVKNTDGS-LTLELEDGRSE-----TVDCLIWAIGREPANDNINLEAAGV 277 Query: 321 EVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHG--HVNYN 378 + +++G +V+D N+ I VGD T L A G E L H++Y+ Sbjct: 278 KTNEKGYIVVDKYQNTNIEGIYAVGDNTGAVELTPVAVAAGRRLSERLFNNKPDEHLDYS 337 Query: 379 NIPSVMYSHPEVAWVGKTEEQLKEAGID--YKIGKFPFAANSRAKTNQDTEGFVKILIDS 436 NIP+V++SHP + VG TE Q +E D K+ K F A A T +K++ Sbjct: 338 NIPTVVFSHPPIGTVGLTEPQAREQYGDDQVKVYKSSFTAMYTAVTTHRQPCRMKLVCVG 397 Query: 437 KTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEAN 489 E+I+G H IG EM+ +AL+ GA+ +D HPT +E F Sbjct: 398 SEEKIVGIHGIGFGMDEMLQGFAVALKMGATKKDFDNTVAIHPTAAEEFVTMR 450 >5VDN-A nrPDB Length = 463 Score = 482 bits (1240), Expect = e-136, Method: Composition-based stats. Identities = 118/478 (24%), Positives = 206/478 (43%), Gaps = 29/478 (6%) Query: 18 VRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALL 77 + T + K +D + IGGG G + +AA G A +E + +LGGTC+NVGC+P K + Sbjct: 9 METTLMTKHYDYLAIGGGSGGIASINRAAMYGKKCALIEAK-QLGGTCVNVGCVPKKVMW 67 Query: 78 NNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKG 137 + + + +H G D + + + + ++ E NKV +G Sbjct: 68 HAAQIAEAIHLYGPDYGFDTTVN-HFDWKKLIANRTAYIDRIHQSYERGLGNNKVDVIQG 126 Query: 138 NGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEV--TPFPGIEIDEEKIVSST 195 F D + V + +I++ATG PG E + S Sbjct: 127 FARFVDAHTVEVN-----------GETITADHILIATGGRPSHPDIPGAE----YGIDSD 171 Query: 196 GALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFL 255 G L E+PKR+ ++G G I +E+ V + LG++ + + + D + + + + Sbjct: 172 GFFELDEMPKRVAVVGAGYIAVEIAGVLNGLGTETHLFVRKHAPLRTFDPLIVETLLEVM 231 Query: 256 KKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGA 315 +G + + +N D + + + +E+ + + L+ A+GR P L Sbjct: 232 NTEGPKLHTESVPKAVIKNADGS-LTLQLENG-----TEVTVDHLIWAIGREPATDNLNL 285 Query: 316 EKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHG-- 373 G++ + +G + +D N+ I VGD T L A G E L Sbjct: 286 SVTGVKTNDKGYIEVDKFQNTNVKGIYAVGDNTGVVELTPVAVAAGRRLSERLFNNKPDE 345 Query: 374 HVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGID--YKIGKFPFAANSRAKTNQDTEGFVK 431 H++Y+NIP+V++SHP + +G TE Q +E D K+ F A A T +K Sbjct: 346 HLDYSNIPTVVFSHPPIGTIGLTEPQAREKFGDDQVKVYTSSFTAMYSAVTQHRQPCRMK 405 Query: 432 ILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEAN 489 ++ E+I+G H IG E++ +A++ GA+ +D HPT +E F Sbjct: 406 LVCVGAEEKIVGIHGIGFGMDEILQGFAVAMKMGATKKDFDNTVAIHPTAAEEFVTMR 463 >2WOV-A nrPDB Length = 495 Score = 475 bits (1224), Expect = e-134, Method: Composition-based stats. Identities = 129/489 (26%), Positives = 212/489 (43%), Gaps = 31/489 (6%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQL-GFNTACVE--------KRGKLGGTCLNVGCIPS 73 ++K+ D+V+IG G G A AA L G A V+ LGGTC+NVGC+P Sbjct: 4 MSKAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPK 63 Query: 74 KALLNNSHLFHQMHTEAQKRGIDVNGD-IKINVANFQKAKDDAVKQLTGGIELLFKKN-K 131 K ++ + + A G + +G +K N AK++AV + E +F Sbjct: 64 KLMVTGAQYMDHLRESA-GFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEG 122 Query: 132 VTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEV--TPFPGIEIDEE 189 + ++ G GS E + + V + VKE L +I++ATGS PGIE Sbjct: 123 LDFFLGWGSLESKNVVVVRETADPKSAVKER--LQADHILLATGSWPQMPAIPGIE---- 176 Query: 190 KIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRL---GSKVTVVEFQPQIGASMDGE 246 +SS A L E P+R+ +GGG I +E +++ G KVT+ I D Sbjct: 177 HCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLCYRNNLILRGFDET 236 Query: 247 VAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGR 306 + + K L G++ + N D + + E KT L+ +V+++A+GR Sbjct: 237 IREEVTKQLTANGIEIMTNENPAKVSLNTDGSK-HVTFESGKT-----LDVDVVMMAIGR 290 Query: 307 RPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVE 366 P L +G+++ +G + +D+ + P+I +GD+T ML A EG A V+ Sbjct: 291 IPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVD 350 Query: 367 MLKTGH-GHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQD 425 + ++ + S ++S P + G EE + + F + Sbjct: 351 TVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSK 410 Query: 426 TEGFV-KILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEA 484 + FV KI+ + +LG H++G A E+I G+ L A D HPT +E Sbjct: 411 YKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAEE 470 Query: 485 FKEANMAAY 493 +Y Sbjct: 471 LCSMRTPSY 479 >2R9Z-A nrPDB Length = 463 Score = 472 bits (1216), Expect = e-133, Method: Composition-based stats. Identities = 128/475 (26%), Positives = 216/475 (45%), Gaps = 29/475 (6%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHL 82 + + D++ IGGG G A KAA G A +E + LGGTC+NVGC+P K + SHL Sbjct: 1 MTQHFDLIAIGGGSGGLAVAEKAAAFGKRVALIESK-ALGGTCVNVGCVPKKVMWYASHL 59 Query: 83 FHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFE 142 + +A G+ +G ++ +D + + + ++ +T G+ F Sbjct: 60 AEAVR-DAPGFGVQASGG-TLDWPRLVAGRDRYIGAINSFWDGYVERLGITRVDGHARFV 117 Query: 143 DETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEV--TPFPGIEIDEEKIVSSTGALSL 200 D I V E L +I++ATG PG E+ ++S G +L Sbjct: 118 DAHTIEV-----------EGQRLSADHIVIATGGRPIVPRLPGAELG----ITSDGFFAL 162 Query: 201 KEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGL 260 ++ PKR+ IIG G IG+E+ + GS+VTVV + ++ D ++ + + QG+ Sbjct: 163 QQQPKRVAIIGAGYIGIELAGLLRSFGSEVTVVALEDRLLFQFDPLLSATLAENMHAQGI 222 Query: 261 DFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGL 320 + L V + +R D +V +D + + ++ AVGR P LG E G+ Sbjct: 223 ETHLEFAVAALER--DAQGTTLVAQDGTRLEG----FDSVIWAVGRAPNTRDLGLEAAGI 276 Query: 321 EVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGH--GHVNYN 378 EV G + D N+ P + +GD+T L A G E L G ++Y+ Sbjct: 277 EVQSNGMVPTDAYQNTNVPGVYALGDITGRDQLTPVAIAAGRRLAERLFDGQSERKLDYD 336 Query: 379 NIPSVMYSHPEVAWVGKTEEQLKEA-GIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSK 437 NIP+V+++HP ++ VG +E + +E G + + F A + +K++ Sbjct: 337 NIPTVVFAHPPLSKVGLSEPEARERLGDVLTVYETSFTPMRYALNEHGPKTAMKLVCAGP 396 Query: 438 TERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAA 492 +R++G H+IG A EM+ +A++ GA+ D HP +E Sbjct: 397 EQRVVGVHVIGDGADEMLQGFAVAVKMGATKADFDNTVAIHPGSAEELVTLKEPV 451 >1EBD-A nrPDB Length = 455 Score = 472 bits (1214), Expect = e-133, Method: Composition-based stats. Identities = 199/464 (42%), Positives = 277/464 (59%), Gaps = 15/464 (3%) Query: 30 VIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTE 89 +++G GP GYVAAI+AAQLG VEK G LGG CLNVGCIPSKAL++ SH + Q Sbjct: 7 LVVGAGPGGYVAAIRAAQLGQKVTIVEK-GNLGGVCLNVGCIPSKALISASHRYEQAK-H 64 Query: 90 AQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRV 149 +++ GI ++ I+ A Q+ K VK+LTGG+E L K NKV KG F D +RV Sbjct: 65 SEEMGIKAE-NVTIDFAKVQEWKASVVKKLTGGVEGLLKGNKVEIVKGEAYFVDANTVRV 123 Query: 150 TPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTI 209 D KN I+ATGS P + +I+ STGAL+L E+PK L + Sbjct: 124 VNGDSA-------QTYTFKNAIIATGSRPIELPNFKFSN-RILDSTGALNLGEVPKSLVV 175 Query: 210 IGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVI 269 IGGG IG+E+G+ Y+ G+KVT++E +I + + ++A +K LKK+G++ + Sbjct: 176 IGGGYIGIELGTAYANFGTKVTILEGAGEILSGFEKQMAAIIKKRLKKKGVEVVTNALAK 235 Query: 270 SAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLV 329 A+ +D + V + + ++A+ +LV VGRRP LG E+IG+++ RG + Sbjct: 236 GAEEREDG----VTVTYEANGETKTIDADYVLVTVGRRPNTDELGLEQIGIKMTNRGLIE 291 Query: 330 IDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYSHPE 389 +D Q + P+I +GD+ GP LAHKA EG A E + V+Y IP+V++S PE Sbjct: 292 VDQQCRTSVPNIFAIGDIVPGPALAHKASYEGKVAAEAIAGHPSAVDYVAIPAVVFSDPE 351 Query: 390 VAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGP 449 A VG E+Q K+ GID KFPFAAN RA DT+GF+K+++ + I+GA IIGP Sbjct: 352 CASVGYFEQQAKDEGIDVIAAKFPFAANGRALALNDTDGFLKLVVRKEDGVIIGAQIIGP 411 Query: 450 NAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAY 493 NA +MIAE GLA+E G +AED+A HAHPTL E EA A Sbjct: 412 NASDMIAELGLAIEAGMTAEDIALTIHAHPTLGEIAMEAAEVAL 455 Score = 28.7 bits (63), Expect = 6.4, Method: Composition-based stats. Identities = 10/33 (30%), Positives = 15/33 (45%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKL 61 +V+IGGG G A G +E G++ Sbjct: 173 LVVIGGGYIGIELGTAYANFGTKVTILEGAGEI 205 >2EQ6-A nrPDB Length = 464 Score = 469 bits (1207), Expect = e-132, Method: Composition-based stats. Identities = 192/480 (40%), Positives = 282/480 (58%), Gaps = 20/480 (4%) Query: 21 LTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNS 80 +T K++D+++IG GP GY AAI+AAQLG VE G++GG CLNVGCIP+KALL+ + Sbjct: 1 MTPMKTYDLIVIGTGPGGYHAAIRAAQLGLKVLAVEA-GEVGGVCLNVGCIPTKALLHAA 59 Query: 81 HLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGS 140 H + A+ G+ + +++ +D VK+LTGG+ L K N V +G Sbjct: 60 ETLHHLKV-AEGFGLKAKPE--LDLKKLGGWRDQVVKKLTGGVGTLLKGNGVELLRGFAR 116 Query: 141 FEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSL 200 ++ V K++I+ATGSE G E + ST AL + Sbjct: 117 LVGPKEVEV-----------GGERYGAKSLILATGSEPLELKGFPFG-EDVWDSTRALKV 164 Query: 201 KE-IPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQG 259 +E +PKRL +IGGG +GLE+G VY RLG++VT++E+ P+I D E A ++ L+K+G Sbjct: 165 EEGLPKRLLVIGGGAVGLELGQVYRRLGAEVTLIEYMPEILPQGDPETAALLRRALEKEG 224 Query: 260 LDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIG 319 + + TK + ++ D + + +E + + E + + +LVAVGR+P GLG EK G Sbjct: 225 IRVRTKTKAVGYEKKKDG--LHVRLEPAEGGEGEEVVVDKVLVAVGRKPRTEGLGLEKAG 282 Query: 320 LEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNN 379 ++VD+RG + ++ + + P + +GD P+LAHKA EG+ A E +Y Sbjct: 283 VKVDERGFIRVNARMETSVPGVYAIGDAARPPLLAHKAMREGLIAAENAAGKDSAFDYQ- 341 Query: 380 IPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTE 439 +PSV+Y+ PE A VG TEE+ K AG K+GKFP AA+ RA T EG VK++ D +T+ Sbjct: 342 VPSVVYTSPEWAGVGLTEEEAKRAGYKVKVGKFPLAASGRALTLGGAEGMVKVVGDEETD 401 Query: 440 RILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIHC 499 +LG I+GP AGE+IAEA LALE GA+ D+A H HPTLSE+ EA A + +AIH Sbjct: 402 LLLGVFIVGPQAGELIAEAALALEMGATLTDLALTVHPHPTLSESLMEAAEAFHKQAIHI 461 >4NEW-A nrPDB Length = 492 Score = 466 bits (1200), Expect = e-132, Method: Composition-based stats. Identities = 120/489 (24%), Positives = 206/489 (42%), Gaps = 32/489 (6%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFN-TACVE--------KRGKLGGTCLNVGCIPS 73 + K D+V+IG G G AA AA L A ++ LGGTC+NVGC+P Sbjct: 2 MPKIFDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGTCVNVGCVPK 61 Query: 74 KALLNNSHLFHQMHTEAQKRGIDVN-GDIKINVANFQKAKDDAVKQLTGGIELLFKKN-K 131 K ++ + + A G + + ++ N KD+AV + + +F+ Sbjct: 62 KLMVTGAQYMEHLRESA-GFGWEFDRTTLRAEWKNLIAVKDEAVLNINKSYDEMFRDTEG 120 Query: 132 VTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEV--TPFPGIEIDEE 189 + ++ G GS E + + V VKE L+ ++I++A+GS PGIE Sbjct: 121 LEFFLGWGSLESKNVVNVRESADPASAVKER--LETEHILLASGSWPHMPNIPGIE---- 174 Query: 190 KIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLG---SKVTVVEFQPQIGASMDGE 246 +SS A L E P+R+ +GGG I +E +++ +VT+ I D Sbjct: 175 HCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPKDGQVTLCYRGEMILRGFDHT 234 Query: 247 VAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGR 306 + + K L G+ + N D + + E K ++ +++++A+GR Sbjct: 235 LREELTKQLTANGIQILTKENPAKVELNADGSK-SVTFESGK-----KMDFDLVMMAIGR 288 Query: 307 RPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVE 366 P L + G+ + K G + +D+ + +I +GDVT ML A E A V+ Sbjct: 289 SPRTKDLQLQNAGVMI-KNGGVQVDEYSRTNVSNIYAIGDVTNRVMLTPVAINEAAALVD 347 Query: 367 MLKTG-HGHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQD 425 + ++ + S ++S P + G EE + + F + Sbjct: 348 TVFGTTPRKTDHTRVASAVFSIPPIGTCGLIEEVASKRYEVVAVYLSSFTPLMHKVSGSK 407 Query: 426 TEGFV-KILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEA 484 + FV KI+ + +LG H++G NA E+I G+ L+ A D HPT +E Sbjct: 408 YKTFVAKIITNHSDGTVLGVHLLGDNAPEIIQGIGICLKLNAKISDFYNTIGVHPTSAEE 467 Query: 485 FKEANMAAY 493 +Y Sbjct: 468 LCSMRTPSY 476 >1ZDL-A nrPDB Length = 517 Score = 464 bits (1195), Expect = e-131, Method: Composition-based stats. Identities = 123/477 (25%), Positives = 212/477 (44%), Gaps = 24/477 (5%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVE--------KRGKLGGTCLNVGCIPSKA 75 +S D+++IGGG G A +AAQLG A + + LGGTC+NVGCIP K Sbjct: 30 QQSFDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKL 89 Query: 76 LLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYY 135 + + + L M +A G +V ++ N +A + VK L G + + KV Y+ Sbjct: 90 M-HQAALLGGMIRDAHHYGWEVAQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKYF 148 Query: 136 KGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSST 195 SF DE +R G +L ++I++ATG ++ E ++S Sbjct: 149 NIKASFVDEHTVRGVDKGGKA------TLLSAEHIVIATGGRPRYPTQVKGALEYGITSD 202 Query: 196 GALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFL 255 LKE P + ++G + LE + +G TV+ + D +++ + + Sbjct: 203 DIFWLKESPGKTLVVGASYVALECAGFLTGIGLDTTVM-MRSIPLRGFDQQMSSLVTEHM 261 Query: 256 KKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGA 315 + G F K+ N +++ ED + K++ + +L A+GR P L Sbjct: 262 ESHGTQFLKGCVPSHIKK-LPTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNL 320 Query: 316 EKIGLEVDKRGR-LVIDDQFNSKFPHIKVVGDVT-FGPMLAHKAEEEGIAAVEMLKTG-H 372 EK G+ + + + +++D Q + PHI +GDV P L A + G + L Sbjct: 321 EKAGISTNPKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSS 380 Query: 373 GHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTE---GF 429 ++Y+N+P+ +++ E VG +EE+ + + T D + + Sbjct: 381 TLMDYSNVPTTVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRDASQCY 440 Query: 430 VKILI-DSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAF 485 +K++ + +LG H +GPNAGE+ L ++ GAS V + HPT SE Sbjct: 441 IKMVCMREPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHPTCSEEV 497 >4JDR-A nrPDB Length = 474 Score = 464 bits (1194), Expect = e-131, Method: Composition-based stats. Identities = 185/461 (40%), Positives = 264/461 (57%), Gaps = 13/461 (2%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHT 88 VV++G GPAGY AA + A LG T VE+ LGG CLNVGCIPSKALL+ + + + Sbjct: 9 VVVLGAGPAGYSAAFRCADLGLETVIVERYNTLGGVCLNVGCIPSKALLHVAKVIEEAKA 68 Query: 89 EAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIR 148 A+ GI V G+ K ++ + K+ + QLTGG+ + K KV G G F + Sbjct: 69 LAE-HGI-VFGEPKTDIDKIRTWKEKVINQLTGGLAGMAKGRKVKVVNGLGKFTGANTLE 126 Query: 149 VTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLT 208 V +G +++ N I+A GS P I ++ +I ST AL LKE+P+RL Sbjct: 127 VEGENGKT-------VINFDNAIIAAGSRPIQLPFIPHEDPRIWDSTDALELKEVPERLL 179 Query: 209 IIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKV 268 ++GGGIIGLEMG+VY LGS++ VVE Q+ + D ++ K K + K+ + L TKV Sbjct: 180 VMGGGIIGLEMGTVYHALGSQIDVVEMFDQVIPAADKDIVKVFTKRISKK-FNLMLETKV 238 Query: 269 ISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRL 328 + + +D V + + K E + +LVA+GR P L A K G+EVD RG + Sbjct: 239 TAVEAKEDGIYVTM---EGKKAPAEPQRYDAVLVAIGRVPNGKNLDAGKAGVEVDDRGFI 295 Query: 329 VIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYSHP 388 +D Q + PHI +GD+ PMLAHK EG A E++ + + IPS+ Y+ P Sbjct: 296 RVDKQLRTNVPHIFAIGDIVGQPMLAHKGVHEGHVAAEVIAGKKHYFDPKVIPSIAYTEP 355 Query: 389 EVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIG 448 EVAWVG TE++ KE GI Y+ FP+AA+ RA + +G K++ D ++ R++G I+G Sbjct: 356 EVAWVGLTEKEAKEKGISYETATFPWAASGRAIASDCADGMTKLIFDKESHRVIGGAIVG 415 Query: 449 PNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEAN 489 N GE++ E GLA+E G AED+A HAHPTL E+ A Sbjct: 416 TNGGELLGEIGLAIEMGCDAEDIALTIHAHPTLHESVGLAA 456 >2YAU-A nrPDB Length = 511 Score = 464 bits (1194), Expect = e-131, Method: Composition-based stats. Identities = 120/491 (24%), Positives = 215/491 (43%), Gaps = 27/491 (5%) Query: 19 RTLTINKSHDVVIIGGGPAGYVAAIKAA-QLGFNTACVEKRGK--------LGGTCLNVG 69 R +++++D+V++G G G A AA A V+ + LGGTC+NVG Sbjct: 17 RGSHMSRAYDLVVLGAGSGGLEAGWNAAVTHKKKVAVVDVQATHGPPLFAALGGTCVNVG 76 Query: 70 CIPSKALLNNSHLFHQMHTEAQKRGIDVNGD-IKINVANFQKAKDDAVKQLTGGIELLFK 128 C+P K ++ + + + E+ G +++ + + N AK+ V + + +F Sbjct: 77 CVPKKLMVTGAQ-YMDLIRESGGFGWEMDRESLCPNWKTLIAAKNKVVNSINESYKSMFA 135 Query: 129 KN-KVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEID 187 ++++ G G+ +D + V + V E LD + I++ATGS T G+ D Sbjct: 136 DTEGLSFHMGFGALQDAHTVVVRKSEDPHSDVLE--TLDTEYILIATGSWPTRL-GVPGD 192 Query: 188 EEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRL---GSKVTVVEFQPQIGASMD 244 E ++S A L++ PKR+ +GGG I +E +++ G V + I D Sbjct: 193 -EFCITSNEAFYLEDAPKRMLCVGGGYIAVEFAGIFNGYKPCGGYVDLCYRGDLILRGFD 251 Query: 245 GEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAV 304 EV K+ K L G+ + + +N+D + N + + +++A+ Sbjct: 252 TEVRKSLTKQLGANGIRVRTNLNPTKITKNEDGS------NHVHFNDGTEEDYDQVMLAI 305 Query: 305 GRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAA 364 GR P L +K G+ K G + +D + +I +GDVT ML A EG A Sbjct: 306 GRVPRSQALQLDKAGVRTGKNGAVQVDAYSKTSVDNIYAIGDVTNRVMLTPVAINEGAAF 365 Query: 365 VEMLKTGHGH-VNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTN 423 VE + G ++ + ++S P + G TEE+ + + F + Sbjct: 366 VETVFGGKPRATDHTKVACAVFSIPPIGTCGMTEEEAAKNYETVAVYASSFTPLMHNISG 425 Query: 424 QDTEGFV-KILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLS 482 + F+ +I+ + +LG H++G +A E+I G+ ++ GA D HPT + Sbjct: 426 SKHKEFMIRIITNESNGEVLGVHMLGDSAPEIIQSVGICMKMGAKISDFHSTIGVHPTSA 485 Query: 483 EAFKEANMAAY 493 E AY Sbjct: 486 EELCSMRTPAY 496 >6DU7-A nrPDB Length = 448 Score = 461 bits (1186), Expect = e-130, Method: Composition-based stats. Identities = 124/452 (27%), Positives = 207/452 (45%), Gaps = 30/452 (6%) Query: 44 KAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIKI 103 +A + G A +E++ KLGGTC+NVGC+P K + + + H + G D+ Sbjct: 21 RAGEHGAQAAVIEEK-KLGGTCVNVGCVPKKIMWYGAQIAETFHQFGEDYGFKTT-DLNF 78 Query: 104 NVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDH 163 + A ++ ++ + + + FK+N V +G+ F D + V Sbjct: 79 DFATLRRNRESYIDRARSSYDGSFKRNGVDLIEGHAEFVDSHTVSVN-----------GE 127 Query: 164 ILDVKNIIVATGSEV--TPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGS 221 ++ K+I++ATG+ PG E+ SS + +E+P+ + I+G G I +E+ Sbjct: 128 LIRAKHIVIATGAHPSIPNIPGAELGG----SSDDVFAWEELPESVAILGAGYIAVELAG 183 Query: 222 VYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVE 281 V G K + + + D + + K +++ L + ++ D + Sbjct: 184 VLHTFGVKTDLFVRRDRPLRGFDSYIVEGLVKEMERTNLPLHTHKVPVKLEKTTDG--IT 241 Query: 282 IVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHI 341 I ED + A ++ A GRRP + GL EK G+ +++RG + +D+ N+ I Sbjct: 242 IHFEDGTS-----HTASQVIWATGRRPNVKGLQLEKAGVTLNERGFIQVDEYQNTVVEGI 296 Query: 342 KVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHG--HVNYNNIPSVMYSHPEVAWVGKTEEQ 399 +GDVT L A + G E L G ++Y+ IP+V++SHP + VG TEEQ Sbjct: 297 YALGDVTGEKELTPVAIKAGRTLSERLFNGKTTAKMDYSTIPTVVFSHPAIGTVGLTEEQ 356 Query: 400 L-KEAGID-YKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAE 457 KE G D K+ K FA+ A T E K++ E+++G H IG EMI Sbjct: 357 AIKEYGQDQIKVYKSSFASMYSACTRNRQESRFKLITAGSEEKVVGLHGIGYGVDEMIQG 416 Query: 458 AGLALEYGASAEDVARVCHAHPTLSEAFKEAN 489 +A++ GA+ D HPT SE F Sbjct: 417 FAVAIKMGATKADFDATVAIHPTSSEEFVTMR 448 >5U1O-A nrPDB Length = 458 Score = 460 bits (1183), Expect = e-130, Method: Composition-based stats. Identities = 117/472 (24%), Positives = 207/472 (43%), Gaps = 26/472 (5%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHL 82 + D + IGGG G +A +AA G A +E + LGGTC+NVGC+P K + + + + Sbjct: 8 MATHFDYICIGGGSGGIASANRAAMYGAKVALIEAQD-LGGTCVNVGCVPKKVMWHGAQI 66 Query: 83 FHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFE 142 M+ A+ G DV+ + + +++ + ++ + + NKV KG F Sbjct: 67 AEAMNLYAEDYGFDVDVK-GFDWSKLVESRQAYIGRIHQSYDRVLGNNKVNVIKGFAKFV 125 Query: 143 DETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKE 202 DE + V +I++A G T P I E + S G L E Sbjct: 126 DEKTVEVN-----------GEHYTADHILIAVGGRPT-IPNIPGA-EYGIDSNGFFDLAE 172 Query: 203 IPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDF 262 PKR+ ++G G I +E+ V LG++ + + S D + + ++ +G Sbjct: 173 QPKRVAVVGAGYIAVEIAGVLHALGTETHLFVRKESPLRSFDPMIIDTLVEVMEAEGPTL 232 Query: 263 KLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEV 322 + + D + + + +E+ E+ + L+ A+GR P + G+ Sbjct: 233 HTHSVPKEVVKEADGS-LTLHLENG-----ESQNVDQLIWAIGRHPATDAINLASTGVAT 286 Query: 323 DKRGRLVIDDQFNSKFPHIKVVGDVT-FGPMLAHKAEEEGIAAVEMLKTGH--GHVNYNN 379 +++G + +D+ + I VGD+ G L A + G E L ++Y+ Sbjct: 287 NEKGYIKVDEYQETNVKGIYCVGDIMEGGIELTPVAVKAGRQLSERLFNNKPNAKMDYDL 346 Query: 380 IPSVMYSHPEVAWVGKTEEQLKEAGI--DYKIGKFPFAANSRAKTNQDTEGFVKILIDSK 437 +P+V++SHP + +G T ++ +E + K+ F A A T +K++ + Sbjct: 347 VPTVVFSHPPIGTIGLTTQEAEEKYGKDNIKVYTSGFTAMYTAVTKHRQPCKMKLVCAGE 406 Query: 438 TERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEAN 489 E ++G H IG EMI G+A++ GA+ D V HPT SE F Sbjct: 407 EETVVGLHGIGFTVDEMIQGFGVAMKMGATKADFDSVVAIHPTGSEEFVTMR 458 >2AAQ-A nrPDB Length = 479 Score = 459 bits (1182), Expect = e-129, Method: Composition-based stats. Identities = 131/475 (27%), Positives = 221/475 (46%), Gaps = 27/475 (5%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQ 85 S+D ++IGGG G +A +AA+LG A VE KLGGTC+NVGC+P K + N + Sbjct: 21 SYDYLVIGGGSGGLASARRAAELGARAAVVESH-KLGGTCVNVGCVPKKVMWNTAVHSEF 79 Query: 86 MHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDET 145 MH A G + + K N ++ +D V +L + K+ + +G+ +F + Sbjct: 80 MHDHA-DYGFP-SCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP 137 Query: 146 KIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVT-----PFPGIEIDEEKIVSSTGALSL 200 K + +I++ATG + PG + ++S G L Sbjct: 138 KPTIE---------VSGKKYTAPHILIATGGMPSTPHESQIPGASLG----ITSDGFFQL 184 Query: 201 KEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGL 260 +E+P R I+G G I +EM + S LGSK +++ ++ S D ++ + L+ G+ Sbjct: 185 EELPGRSVIVGAGYIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGV 244 Query: 261 DFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENL--EAEVLLVAVGRRPYIAGLGAEKI 318 + ++V K+ V +V + + + LL A+GR P L K+ Sbjct: 245 EVLKFSQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKL 304 Query: 319 GLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLK--TGHGHVN 376 G++ D +G +++D+ N+ I VGDV +L A G L ++ Sbjct: 305 GIQTDDKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLD 364 Query: 377 YNNIPSVMYSHPEVAWVGKTEEQL-KEAGID-YKIGKFPFAANSRAKTNQDTEGFVKILI 434 YNNIP+V++SHP + VG TE++ + GI+ K F A T + T+ +K++ Sbjct: 365 YNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVC 424 Query: 435 DSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEAN 489 +K E+++G H+ G EM+ +A++ GA+ D HPT SE Sbjct: 425 ANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 479 >1FEC-A nrPDB Length = 490 Score = 459 bits (1182), Expect = e-129, Method: Composition-based stats. Identities = 123/486 (25%), Positives = 213/486 (43%), Gaps = 27/486 (5%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFN-TACVE--------KRGKLGGTCLNVGCIPSK 74 ++++D+V+IG G G A AA L A ++ LGGTC+NVGC+P K Sbjct: 1 SRAYDLVVIGAGSGGLEAGWNAASLHKKRVAVIDLQKHHGPPHYAALGGTCVNVGCVPKK 60 Query: 75 ALLNNSHLFHQMHTEAQKRGIDVNGD-IKINVANFQKAKDDAVKQLTGGIELLFKKN-KV 132 ++ ++ + A G +++ + ++ N AK+ AV + E +F + Sbjct: 61 LMVTGANYMDTIRESA-GFGWELDRESVRPNWKALIAAKNKAVSGINDSYEGMFADTEGL 119 Query: 133 TYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIV 192 T+++G G+ +D + V V E LD + I++ATGS GIE D + + Sbjct: 120 TFHQGFGALQDNHTVLVRESADPNSAVLE--TLDTEYILLATGSWPQHL-GIEGD-DLCI 175 Query: 193 SSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRL---GSKVTVVEFQPQIGASMDGEVAK 249 +S A L E PKR +GGG I +E +++ G +V + I D E+ K Sbjct: 176 TSNEAFYLDEAPKRALCVGGGYISIEFAGIFNAYKARGGQVDLAYRGDMILRGFDSELRK 235 Query: 250 ATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPY 309 + L+ G++ + +N D +V E + +V+++A+GR P Sbjct: 236 QLTEQLRANGINVRTHENPAKVTKNADGTR-HVVFESGA-----EADYDVVMLAIGRVPR 289 Query: 310 IAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLK 369 L EK G+EV K G + +D + +I +GDVT ML A EG A V+ + Sbjct: 290 SQTLQLEKAGVEVAKNGAIKVDAYSKTNVDNIYAIGDVTDRVMLTPVAINEGAAFVDTVF 349 Query: 370 TGHGH-VNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEG 428 ++ + ++S P + G EE + + + F + + Sbjct: 350 ANKPRATDHTKVACAVFSIPPMGVCGYVEEDAAKKYDQVAVYESSFTPLMHNISGSTYKK 409 Query: 429 FV-KILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKE 487 F+ +I+ + +LG H++G ++ E+I + L+ GA D HPT +E Sbjct: 410 FMVRIVTNHADGEVLGVHMLGDSSPEIIQSVAICLKMGAKISDFYNTIGVHPTSAEELCS 469 Query: 488 ANMAAY 493 AY Sbjct: 470 MRTPAY 475 >2HQM-A nrPDB Length = 479 Score = 457 bits (1175), Expect = e-129, Method: Composition-based stats. Identities = 127/482 (26%), Positives = 232/482 (48%), Gaps = 31/482 (6%) Query: 22 TINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSH 81 T K +D ++IGGG G +A +AA G T VE + LGGTC+NVGC+P K + S Sbjct: 7 TNTKHYDYLVIGGGSGGVASARRAASYGAKTLLVEAK-ALGGTCVNVGCVPKKVMWYASD 65 Query: 82 LFHQMHTEAQKRGIDVN-----GDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYK 136 L ++ + A + G+ N + N F++ +D V +L G + +K KV Sbjct: 66 LATRV-SHANEYGLYQNLPLDKEHLTFNWPEFKQKRDAYVHRLNGIYQKNLEKEKVDVVF 124 Query: 137 GNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSE---VTPFPGIEIDEEKIVS 193 G F + + V D + +I+VATG + PG E+ Sbjct: 125 GWARFNKDGNVEVQKRDNTT------EVYSANHILVATGGKAIFPENIPGFELGT----D 174 Query: 194 STGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQK 253 S G L+E PK++ ++G G IG+E+ V+ LGS+ +V + D + Sbjct: 175 SDGFFRLEEQPKKVVVVGAGYIGIELAGVFHGLGSETHLVIRGETVLRKFDECIQNTITD 234 Query: 254 FLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGL 313 K+G++ +K++ ++N + + ++I + D+K+ + + L+ +GR+ ++ G+ Sbjct: 235 HYVKEGINVHKLSKIVKVEKNVETDKLKIHMNDSKSID----DVDELIWTIGRKSHL-GM 289 Query: 314 GAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKT--- 370 G+E +G++++ +++ D+ N+ P+I +GDV L A G L Sbjct: 290 GSENVGIKLNSHDQIIADEYQNTNVPNIYSLGDVVGKVELTPVAIAAGRKLSNRLFGPEK 349 Query: 371 -GHGHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAG--IDYKIGKFPFAANSRAKTNQDTE 427 + ++Y N+PSV++SHPE +G +E++ E + K+ F A A ++ + Sbjct: 350 FRNDKLDYENVPSVIFSHPEAGSIGISEKEAIEKYGKENIKVYNSKFTAMYYAMLSEKSP 409 Query: 428 GFVKILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKE 487 KI+ E+++G HI+G ++ E++ G+A++ GA+ D HPT +E Sbjct: 410 TRYKIVCAGPNEKVVGLHIVGDSSAEILQGFGVAIKMGATKADFDNCVAIHPTSAEELVT 469 Query: 488 AN 489 Sbjct: 470 MR 471 >5V36-A nrPDB Length = 453 Score = 457 bits (1175), Expect = e-129, Method: Composition-based stats. Identities = 115/471 (24%), Positives = 197/471 (41%), Gaps = 25/471 (5%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHL 82 + K +D ++IGGG G +A +AA G E + ++GGTC+NVGC+P K + + + Sbjct: 4 MTKQYDYIVIGGGSGGIASANRAAMHGAKVILFEGK-QVGGTCVNVGCVPKKVMWYGAQV 62 Query: 83 FHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFE 142 ++ A G DV + ++ + + ++ E F N V G +F Sbjct: 63 AETINNYAADYGFDVTTQ-AFHFDVLKQNRQAYIDRIHDSYERGFDSNGVERVYGYATFV 121 Query: 143 DETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKE 202 D + V +I++ATG P I E ++S G L Sbjct: 122 DAHTVEV-----------AGEHYTAPHILIATGGHAL-LPDIP-GSEYGITSDGFFELDA 168 Query: 203 IPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDF 262 IPKR ++G G I +E+ + LGS+ + + + D E+ +KK G Sbjct: 169 IPKRTAVVGAGYIAVEISGILHALGSETHLFVRRDRPLRKFDKEIVGTLVDEMKKDGPHL 228 Query: 263 KLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEV 322 + +N D ++ I+ E + L+ A+GR G E G+ + Sbjct: 229 HTFSVPKEVIKNTDNSLTLIL------ENGEEYTVDTLIWAIGRAANTKGFNLEVTGVTL 282 Query: 323 DKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGH--GHVNYNNI 380 D RG + D N+ + +GDV L A + G E L ++Y ++ Sbjct: 283 DSRGFIATDAFENTNVEGLYALGDVNGKLELTPVAVKAGRQLSERLFNHKPQAKMDYKDV 342 Query: 381 PSVMYSHPEVAWVGKTEEQLKEAGID--YKIGKFPFAANSRAKTNQDTEGFVKILIDSKT 438 +V++SHP + +G +EE + + + + F + A T+ +K++ + Sbjct: 343 ATVIFSHPVIGSIGLSEEAALDQYGEENVTVYRSTFTSMYTAVTSHRQACKMKLVTVGED 402 Query: 439 ERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEAN 489 E+I+G H IG EMI +A++ GA+ D HPT SE F Sbjct: 403 EKIVGLHGIGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR 453 >2X8H-A nrPDB Length = 598 Score = 456 bits (1173), Expect = e-128, Method: Composition-based stats. Identities = 124/482 (25%), Positives = 216/482 (44%), Gaps = 30/482 (6%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVE--------KRGKLGGTCLNVGCIPSKALLN 78 +D+++IGGG G A +AA+ G TA ++ LGGTC+NVGCIP K + + Sbjct: 108 YDLIVIGGGSGGLAAGKEAAKYGAKTAVLDYVEPTPIGTTWGLGGTCVNVGCIPKKLM-H 166 Query: 79 NSHLFHQMHTEAQKRGIDVN-GDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKG 137 + L +A+ G ++ I N + + + L G ++ + N+VTY Sbjct: 167 QAGLLSHALEDAEHFGWSLDRSKISHNWSTMVEGVQSHIGSLNWGYKVALRDNQVTYLNA 226 Query: 138 NGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGA 197 G ++++T + T+ + II+ATG E +P I E ++S Sbjct: 227 KGRLISPHEVQITDKNQKVSTITGN------KIILATG-ERPKYPEIPGAVEYGITSDDL 279 Query: 198 LSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKK 257 SL P + +IG + LE + LG VTV+ + D ++A+ +++ Sbjct: 280 FSLPYFPGKTLVIGASYVALECAGFLASLGGDVTVMVR-SILLRGFDQQMAEKVGDYMEN 338 Query: 258 QGLDFKLSTKVISAKR------NDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIA 311 G+ F K+ ++K + +V K+ E E ++ AVGR P ++ Sbjct: 339 HGVKFAKLCVPDEIKQLKVVDTENNKPGLLLVKGHYTDGKKFEEEFETVIFAVGREPQLS 398 Query: 312 GLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVT-FGPMLAHKAEEEGIAAVEMLKT 370 + E +G+++DK GR+V D + ++ +GD+ P L A + G L Sbjct: 399 KVLCETVGVKLDKNGRVVCTDDEQTTVSNVYAIGDINAGKPQLTPVAIQAGRYLARRLFA 458 Query: 371 GHGHV-NYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKT---NQDT 426 G + +Y+N+ + +++ E G +EE E D I + T +D Sbjct: 459 GATELTDYSNVATTVFTPLEYGACGLSEEDAIEKYGDKDIEVYHSNFKPLEWTVAHREDN 518 Query: 427 EGFVKILIDS-KTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAF 485 ++K++ R+LG H++GPNAGE+ +A++ GA+ D R HPT SE F Sbjct: 519 VCYMKLVCRKSDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKADFDRTIGIHPTCSETF 578 Query: 486 KE 487 Sbjct: 579 TT 580 >6B4O-A nrPDB Length = 452 Score = 451 bits (1160), Expect = e-127, Method: Composition-based stats. Identities = 120/470 (25%), Positives = 202/470 (42%), Gaps = 25/470 (5%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLF 83 K++D ++IGGG G +A +A G N +E ++GGTC+NVGC+P K + S + Sbjct: 4 MKTYDYIVIGGGSGGIASANRAGMHGANVLLIEGN-EIGGTCVNVGCVPKKVMWQASSMM 62 Query: 84 HQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFED 143 M + G DV + + ++ + L G N + G +F Sbjct: 63 EMMERDTAGYGFDVEIK-NFSFKQLVENREKYIDFLHGAYNRGLDSNNIERIHGYATFTG 121 Query: 144 ETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEI 203 E I V + +I++ATG GI EE + S G +L+E+ Sbjct: 122 EQTIEVNGTE-----------YTAPHILIATGGRPKKL-GIP-GEEYALDSNGFFALEEM 168 Query: 204 PKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFK 263 PKR+ +G G I E+ LG++ + S D +++ + ++ G+ Sbjct: 169 PKRVVFVGAGYIAAELAGTLHGLGAETHWAFRHERPLRSFDDMLSEKVVERYQEMGMQIH 228 Query: 264 LSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVD 323 + ++ V I E+ E++ + ++ GR+P LG E + +D Sbjct: 229 PNATPAKIEKTAQNEYV-ITFENG-----ESITTDAVIFGTGRQPNTDQLGLENTKVALD 282 Query: 324 KRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHG--HVNYNNIP 381 ++G + +D N+ I VGDV L A G E L G +++YN +P Sbjct: 283 EKGYVKVDKFQNTTQNGIYAVGDVIGKIDLTPVAIAAGRRLSERLFNGQTDLYLDYNLVP 342 Query: 382 SVMYSHPEVAWVGKTEEQLKEAGID--YKIGKFPFAANSRAKTNQDTEGFVKILIDSKTE 439 +V+++HP VA +G TE+ E + KI + F A + +K++ K E Sbjct: 343 TVVFTHPPVATIGLTEKAALEEYGEDQVKIYRSSFTPMYFALGEYRQKCDMKLICVGKEE 402 Query: 440 RILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEAN 489 +I+G H IG EM+ +A++ GA+ D HPT SE F Sbjct: 403 KIVGLHGIGIGVDEMLQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR 452 >2CFY-A nrPDB Length = 521 Score = 450 bits (1158), Expect = e-127, Method: Composition-based stats. Identities = 109/464 (23%), Positives = 205/464 (44%), Gaps = 30/464 (6%) Query: 43 IKAAQLGFNTACVEK--------RGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRG 94 +AAQ G ++ R LGGTC+NVGCIP K + + + L Q +++ G Sbjct: 51 KEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLM-HQAALLGQALQDSRNYG 109 Query: 95 IDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDG 154 V +K + +A + + L G + ++ KV Y G F +I+ T G Sbjct: 110 WKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKG 169 Query: 155 LEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGI 214 E I + ++ATG GI D+E +SS SL P + ++G Sbjct: 170 KE------KIYSAERFLIATGERPRYL-GIPGDKEYCISSDDLFSLPYCPGKTLVVGASY 222 Query: 215 IGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRN 274 + LE + +G VTV+ + D ++A + +++ G+ F I ++ Sbjct: 223 VALECAGFLAGIGLDVTVMVR-SILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQI 281 Query: 275 DDK--NVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKR-GRLVID 331 + + +V + T + + E +++A+GR +G E +G++++++ G++ + Sbjct: 282 EAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVT 341 Query: 332 DQFNSKFPHIKVVGDVT-FGPMLAHKAEEEGIAAVEMLKTGHG-HVNYNNIPSVMYSHPE 389 D+ + P+I +GD+ L A + G + L G +Y N+P+ +++ E Sbjct: 342 DEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLE 401 Query: 390 VAWVGKTEEQLKEAGID-----YKIGKFPFAANSRAKTNQDTEGFVKILID-SKTERILG 443 G +EE+ E + Y +P ++ N + + KI+ + ER++G Sbjct: 402 YGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNN--KCYAKIICNTKDNERVVG 459 Query: 444 AHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKE 487 H++GPNAGE+ AL+ G + + + HP +E F Sbjct: 460 FHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTT 503 >4KPR-E nrPDB Length = 499 Score = 449 bits (1155), Expect = e-126, Method: Composition-based stats. Identities = 108/464 (23%), Positives = 204/464 (43%), Gaps = 30/464 (6%) Query: 43 IKAAQLGFNTACVEK--------RGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRG 94 +AA+ ++ R LGGTC+NVGCIP K + + + L Q +++ G Sbjct: 29 KEAAKFDKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLM-HQAALLGQALKDSRNYG 87 Query: 95 IDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDG 154 + +K + ++ + + L G + ++ KV Y G F KI T G Sbjct: 88 WKLEDTVKHDWEKMTESVQNHIGSLNWGYRVALREKKVVYENAYGKFIGPHKIMATNNKG 147 Query: 155 LEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGI 214 E + + ++ATG GI D+E +SS SL P + ++G Sbjct: 148 KE------KVYSAERFLIATGERPRYL-GIPGDKEYCISSDDLFSLPYCPGKTLVVGASY 200 Query: 215 IGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRN 274 + LE + +G VTV+ + D ++A + +++ G+ F ++ Sbjct: 201 VALECAGFLAGIGLDVTVMVR-SILLRGFDQDMANKIGEHMEEHGIKFIRQFVPTKIEQI 259 Query: 275 DDKNVVEIVVEDTKTNKQENL--EAEVLLVAVGRRPYIAGLGAEKIGLEVDKR-GRLVID 331 + + V TN +E + E +L+AVGR +G E +G++++++ G++ + Sbjct: 260 EAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTIGLETVGVKINEKTGKIPVT 319 Query: 332 DQFNSKFPHIKVVGDVTFGP-MLAHKAEEEGIAAVEMLKTGHG-HVNYNNIPSVMYSHPE 389 D+ + P+I +GD+ G L A + G + L G +Y+N+P+ +++ E Sbjct: 320 DEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTVKCDYDNVPTTVFTPLE 379 Query: 390 VAWVGKTEEQLKEAGID-----YKIGKFPFAANSRAKTNQDTEGFVKILID-SKTERILG 443 G +EE+ E + Y +P ++ N + + K++ + ER++G Sbjct: 380 YGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDNN--KCYAKVICNLKDNERVVG 437 Query: 444 AHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKE 487 H++GPNAGE+ AL+ G + + + HP +E F Sbjct: 438 FHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTT 481 >4LA1-A nrPDB Length = 602 Score = 448 bits (1154), Expect = e-126, Method: Composition-based stats. Identities = 117/466 (25%), Positives = 207/466 (44%), Gaps = 30/466 (6%) Query: 43 IKAAQLGFNTACVE--------KRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRG 94 +AA+ G A ++ LGGTC+NVGCIP K + + + L +AQ G Sbjct: 130 KEAAKYGAKIAVLDYVEPTPMGTTWGLGGTCVNVGCIPKKLM-HQAGLLSHSLEDAQHFG 188 Query: 95 IDVN-GDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVD 153 ++ +I + + + + L G ++ + N VTY G ++++T + Sbjct: 189 WSLDKSEISHDWSTMVEGVQSHIGSLNWGYKVSLRDNAVTYLNARGMLLSPHEVQITEKN 248 Query: 154 GLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGG 213 T+ + II+ATG E +P I E ++S SL P + ++G Sbjct: 249 KKVSTITGN------KIILATG-ERPKYPEIPGAIEYGITSDDLFSLPYFPGKTLVVGAS 301 Query: 214 IIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLS------TK 267 + L+ + LG VTV+ + D ++A+ +++ G+ F T+ Sbjct: 302 YVALKCAGFLASLGGDVTVMVR-SILLRGFDQQMAEKVGDYMENHGVKFAKLCVPDEITQ 360 Query: 268 VISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGR 327 + ++K + +V K+ E E ++ AVGR P ++ L E +G+++DK GR Sbjct: 361 LKPVDTENNKPGLLLVKGHYTDGKKFEEEFETVIFAVGREPQLSKLNCEAVGVKLDKNGR 420 Query: 328 LVIDDQFNSKFPHIKVVGDVT-FGPMLAHKAEEEGIAAVEMLKTGHGHV-NYNNIPSVMY 385 +V D + +I +GD+ P L A G L G + +Y+N+ + ++ Sbjct: 421 VVCSDDEQTTVSNIYAIGDINAGKPQLTPVAIHAGRYLARRLFAGATELTDYSNVATTVF 480 Query: 386 SHPEVAWVGKTEEQLKEAGID--YKIGKFPFAANSRAKTN-QDTEGFVKILID-SKTERI 441 + E G +EE E D ++ F + +D ++K++ S R+ Sbjct: 481 TPLEYGACGLSEEDAIEKYGDNDIEVYHSHFKPLEWTVAHREDNVCYMKLVCRISDNMRV 540 Query: 442 LGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKE 487 LG H++GPNAGE+ +A++ GA+ ED R HPT SE F Sbjct: 541 LGLHVLGPNAGEITQGYAVAIKMGATKEDFDRTIGIHPTCSETFTT 586 >6CMZ-A nrPDB Length = 466 Score = 442 bits (1137), Expect = e-124, Method: Composition-based stats. Identities = 175/479 (36%), Positives = 251/479 (52%), Gaps = 21/479 (4%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLF 83 N+ +++IGGGP GYVAAI+A QLG T VE R +LGGTCLN+GCIPSKAL++ + F Sbjct: 6 NEHTTLLVIGGGPGGYVAAIRAGQLGIPTVLVE-RDRLGGTCLNIGCIPSKALIHVADAF 64 Query: 84 HQMHTEAQK--RGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSF 141 Q A + GI V +I++A KD V +LT G+ L KK+ V G Sbjct: 65 EQACGHAGEGALGIRVRA-PEIDIAKSVAWKDGIVDRLTRGVGALLKKSGVRVLHGEARV 123 Query: 142 EDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLK 201 D + V + +++++ATGSE P + +VSST ALS Sbjct: 124 IDGKTVEVVSAGHAVR-------IGCEHLLLATGSEPVELPSMPFGG-HVVSSTDALSPA 175 Query: 202 EIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLD 261 +PKRL ++G G IGLE+G VY +LG V+VVE ++ + D E+ + L + G+ Sbjct: 176 TLPKRLVVVGAGYIGLELGIVYRKLGVDVSVVEAAERVLPAYDAELVRPVADSLARLGVR 235 Query: 262 FKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLE 321 L KV+ ++ V ++ L A+ +LVAVGRRP + G G E L Sbjct: 236 LWLGHKVLGLDKHGAVRVQ------AADGAEQTLPADRVLVAVGRRPRVDGFGLET--LM 287 Query: 322 VDKRGR-LVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNI 380 +D+ GR L IDD + ++ +GDV PMLAH+A +G E++ I Sbjct: 288 LDRNGRALRIDDTCRTSMRNVWAIGDVAGEPMLAHRAMAQGEMVAELIAGRRRQFMPAAI 347 Query: 381 PSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTER 440 P+V ++ PE+ G + + AG+D FPFAAN RA T Q T+GFV+++ Sbjct: 348 PAVCFTDPEIVTAGWSPDDAHAAGVDCLSASFPFAANGRAMTLQATDGFVRVVARRDNHL 407 Query: 441 ILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIHC 499 I+G +G E+ A +LE GA ED+ HAHPTL EA +EA + A A+H Sbjct: 408 IVGWQAVGRGVSELAAAFSQSLEMGARLEDIGGTIHAHPTLGEALQEAALRALGHALHV 466 >2NVK-X nrPDB Length = 488 Score = 441 bits (1134), Expect = e-124, Method: Composition-based stats. Identities = 117/479 (24%), Positives = 210/479 (43%), Gaps = 27/479 (5%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEK---------RGKLGGTCLNVGCIPSKALL 77 +D+++IGGG AG A +A G AC++ + +GGTC+NVGCIP K + Sbjct: 10 YDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKKLM- 68 Query: 78 NNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKG 137 + + L + EA G +V+ IK + ++ + +K + + + KV Y G Sbjct: 69 HQASLLGEAVHEAAAYGWNVDDKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEYING 128 Query: 138 NGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGA 197 GSF D + G + + + ++A G +P I E ++S Sbjct: 129 LGSFVDSHTLLAKLKSG-------ERTITAQTFVIAVGGRPR-YPDIPGAVEYGITSDDL 180 Query: 198 LSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKK 257 SL P + ++G G IGLE LG + TV+ + D ++A+ +++ Sbjct: 181 FSLDREPGKTLVVGAGYIGLECAGFLKGLGYEPTVMVR-SIVLRGFDQQMAELVAASMEE 239 Query: 258 QGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEK 317 +G+ F T +S ++ DD ++ + ++ +T ++ + +L A+GR+ + L Sbjct: 240 RGIPFLRKTVPLSVEKQDDGKLL-VKYKNVETGEESEDVYDTVLWAIGRKGLVDDLNLPN 298 Query: 318 IGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFG-PMLAHKAEEEGIAAVEMLKTGHG-HV 375 G+ V K ++ +D Q + +I VGD+ +G P L A G L G + Sbjct: 299 AGVTVQKD-KIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRM 357 Query: 376 NYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTE---GFVKI 432 +Y ++ + +++ E A VG +EE + +I F ++K Sbjct: 358 DYKDVATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQKSVRYCYLKA 417 Query: 433 LI-DSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANM 490 + +R+ G H IGP AGE+I AL+ G + + HPT +E F + Sbjct: 418 VAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLAI 476 >1LVL-A nrPDB Length = 458 Score = 432 bits (1111), Expect = e-121, Method: Composition-based stats. Identities = 171/473 (36%), Positives = 254/473 (53%), Gaps = 24/473 (5%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQM-- 86 ++IIGGGP GYVAAI+A QLG T VE + LGGTCLN+GCIPSKAL++ + FHQ Sbjct: 8 LLIIGGGPGGYVAAIRAGQLGIPTVLVEGQ-ALGGTCLNIGCIPSKALIHVAEQFHQASR 66 Query: 87 HTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETK 146 TE GI V ++++ KD V +LT G+ L KK+ V G D + Sbjct: 67 FTEPSPLGISV-ASPRLDIGQSVAWKDGIVDRLTTGVAALLKKHGVKVVHGWAKVLDGKQ 125 Query: 147 IRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKR 206 + V + + +++++ATGS P + + ++SST AL+ K +P+ Sbjct: 126 VEV-----------DGQRIQCEHLLLATGSSSVELPMLPLGGP-VISSTEALAPKALPQH 173 Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLST 266 L ++GGG IGLE+G Y +LG++V+VVE + +I + D E+ + LKK G+ L Sbjct: 174 LVVVGGGYIGLELGIAYRKLGAQVSVVEARERILPTYDSELTAPVAESLKKLGIALHLGH 233 Query: 267 KVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRG 326 V + ++ D K + LEA+ +LVAVGRRP G E + L+++ Sbjct: 234 SVEGYENGC------LLANDGKGGQL-RLEADRVLVAVGRRPRTKGFNLECLDLKMN-GA 285 Query: 327 RLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYS 386 + ID++ + ++ +GDV PMLAH+A +G E++ I +V ++ Sbjct: 286 AIAIDERCQTSMHNVWAIGDVAGEPMLAHRAMAQGEMVAEIIAGKARRFEPAAIAAVCFT 345 Query: 387 HPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHI 446 PEV VGKT EQ + G+D + +FPFAAN RA + + GFV+++ ILG Sbjct: 346 DPEVVVVGKTPEQASQQGLDCIVAQFPFAANGRAMSLESKSGFVRVVARRDNHLILGWQA 405 Query: 447 IGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIHC 499 +G E+ +LE GA EDVA HAHPTL EA +EA + A A+H Sbjct: 406 VGVAVSELSTAFAQSLEMGACLEDVAGTIHAHPTLGEAVQEAALRALGHALHI 458 >3O0H-A nrPDB Length = 484 Score = 427 bits (1097), Expect = e-120, Method: Composition-based stats. Identities = 113/468 (24%), Positives = 215/468 (45%), Gaps = 21/468 (4%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQM 86 D+ +IG G G AA A LG A E+ ++GGTC+ GC+P K S + Sbjct: 27 FDLFVIGSGSGGVRAARLAGALGKRVAIAEEY-RIGGTCVIRGCVPKKLYFYASQYAQEF 85 Query: 87 HTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETK 146 + G I N AK+ + +L G + + V Y+ F DE Sbjct: 86 SK-SIGFGWKYADPI-FNWEKLVAAKNKEISRLEGLYREGLQNSNVHIYESRAVFVDEHT 143 Query: 147 IRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKR 206 + ++ + + I++ATG+++ I+ + ++S L+++PK Sbjct: 144 LELS---------VTGERISAEKILIATGAKIVSNSAIK-GSDLCLTSNEIFDLEKLPKS 193 Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLST 266 + I+GGG IG+E +++ LG K T++ I + D ++ + + +G+ Sbjct: 194 IVIVGGGYIGVEFANIFHGLGVKTTLLHRGDLILRNFDYDLRQLLNDAMVAKGISIIYEA 253 Query: 267 KVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRG 326 V + ++ +V+ + +T + A+ +++A GR P GLG E+ G++V++ G Sbjct: 254 TVSQVQSTEN--CYNVVLTNGQT-----ICADRVMLATGRVPNTTGLGLERAGVKVNEFG 306 Query: 327 RLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHV-NYNNIPSVMY 385 +V+D++ + HI VGDVT L A + + V+ +Y+ I + ++ Sbjct: 307 AVVVDEKMTTNVSHIWAVGDVTGHIQLTPVAIHDAMCFVKNAFENTSTTPDYDLITTAVF 366 Query: 386 SHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAH 445 S PE+ VG +EE +I + F + + F+K+++D ++ ++GAH Sbjct: 367 SQPEIGTVGLSEEDALHRYKRVEIYRTVFRPMRNVLSGSPEKMFMKLVVDGESRIVVGAH 426 Query: 446 IIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAY 493 ++G NAGE+ G++L+ + + + HPT+SE +Y Sbjct: 427 VLGENAGEIAQLIGISLKGKLTKDIFDKTMAVHPTMSEELVTMYKPSY 474 >4B1B-A nrPDB Length = 542 Score = 425 bits (1092), Expect = e-119, Method: Composition-based stats. Identities = 121/489 (24%), Positives = 211/489 (43%), Gaps = 42/489 (8%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVE--------KRGKLGGTCLNVGCIPSKALLN 78 +D V+IGGGP G +A +AA G + + +GGTC+NVGC+P K + Sbjct: 43 YDYVVIGGGPGGMASAKEAAAHGARVLLFDYVKPSSQGTKWGIGGTCVNVGCVPKKLMHY 102 Query: 79 NSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGN 138 H+ +++ G + ++K + ++ L + +KV Y G Sbjct: 103 AGHMGSIFKLDSKAYGWKFD-NLKHDWKKLVTTVQSHIRSLNFSYMTGLRSSKVKYINGL 161 Query: 139 GSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGAL 198 +D+ + L+G + ++ + K I++ATG +E +E ++S Sbjct: 162 AKLKDKNTVSYY----LKGDLSKEETVTGKYILIATGCRPHIPDDVEGAKELSITSDDIF 217 Query: 199 SLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQ 258 SLK+ P + ++G + LE + LG VTV + + D + A + ++++Q Sbjct: 218 SLKKDPGKTLVVGASYVALECSGFLNSLGYDVTV-AVRSIVLRGFDQQCAVKVKLYMEEQ 276 Query: 259 GLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKI 318 G+ FK + DDK +VE ++K L + +L A+GR+ I GL E + Sbjct: 277 GVMFKNGILPKKLTKMDDKILVEF------SDKTSEL-YDTVLYAIGRKGDIDGLNLESL 329 Query: 319 GLEVDK-RGRLVIDDQFNSKFPHIKVVGDVTFG-PMLAHKAEEEGIAAVEMLKT-GHGHV 375 + V+K +++ D + P I VGDV P LA A + G L + Sbjct: 330 NMNVNKSNNKIIADHLSCTNIPSIFAVGDVAENVPELAPVAIKAGEILARRLFKDSDEIM 389 Query: 376 NYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKF-------PFAANSRAKTNQDTE- 427 +Y+ IP+ +Y+ E G +EE+ E + F +A R K + + Sbjct: 390 DYSYIPTSIYTPIEYGACGYSEEKAYELYGKSNVEVFLQEFNNLEISAVHRQKHIRAQKD 449 Query: 428 ---------GFVKILI-DSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHA 477 K++ ++ R++G H +GPNAGE+ LAL +D Sbjct: 450 EYDLDVSSTCLAKLVCLKNEDNRVIGFHYVGPNAGEVTQGMALALRLKVKKKDFDNCIGI 509 Query: 478 HPTLSEAFK 486 HPT +E+F Sbjct: 510 HPTDAESFM 518 >5X1Y-B nrPDB Length = 554 Score = 422 bits (1084), Expect = e-118, Method: Composition-based stats. Identities = 148/479 (30%), Positives = 251/479 (52%), Gaps = 21/479 (4%) Query: 21 LTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNS 80 L ++D++IIG G A + +AIKA + G +E RG +GGTC+N+GC+PSK LL Sbjct: 79 LINEDNYDLLIIGSGAAAFSSAIKAIEYGAKVGMIE-RGTVGGTCVNIGCVPSKTLLRAG 137 Query: 81 HLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQL-TGGIELLFKKNKVTYYKGNG 139 + H + + G+ + ++++A+ KD V +L L + KG Sbjct: 138 EIIH-LSKDNPFIGLQTSAG-EVDLASLITQKDKLVSELRNQKYMDLIDEYNFDLIKGEA 195 Query: 140 SFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALS 199 F D + + V L K ++ATG+ + +++ ++ST L Sbjct: 196 KFVDASTVEVNGAK-----------LSAKRFLIATGASPSLPQISGLEKMDYLTSTTLLE 244 Query: 200 LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQG 259 LK+IPKRLT+IG G IG+E+G ++ LGS++T+++ ++ D E++++ +K L +QG Sbjct: 245 LKKIPKRLTVIGSGYIGMELGQLFHHLGSEITLMQRSERLLKEYDPEISESVEKALIEQG 304 Query: 260 LDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIG 319 ++ +++ + V + V +E +E++ LLVA GR+P L G Sbjct: 305 INLVKGATFERVEQSGEIKRVYVTVN----GSREVIESDQLLVATGRKPNTDSLNLSAAG 360 Query: 320 LEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEG-IAAVEMLKTGHGHVNYN 378 +E K ++I+D + I GDVT GP + A EG I + + ++ + Sbjct: 361 VETGKNNEILINDFGQTSNEKIYAAGDVTLGPQFVYVAAYEGGIITDNAIGGLNKKIDLS 420 Query: 379 NIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKT 438 +P+V +++P VA VG TEEQ KE G D K P A RA N++T G K++ D++T Sbjct: 421 VVPAVTFTNPTVATVGLTEEQAKEKGYDVKTSVLPLDAVPRAIVNRETTGVFKLVADAET 480 Query: 439 ERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAI 497 ++LG HI+ NAG++I A LA+++G + ED+ + T++E K A + +DK I Sbjct: 481 LKVLGVHIVSENAGDVIYAASLAVKFGLTVEDLTETLAPYLTMAEGLKLAAL-TFDKDI 538 >5W1J-A nrPDB Length = 584 Score = 420 bits (1080), Expect = e-118, Method: Composition-based stats. Identities = 124/489 (25%), Positives = 202/489 (41%), Gaps = 35/489 (7%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEK--------RGKLGGTCLNVGCIPSK 74 + +D+VIIGGG G A ++A+ G A ++ LGGTC+NVGCIP K Sbjct: 100 MKYDYDMVIIGGGSGGLALAKESAKSGAKVALLDFVVPTPMGTTWGLGGTCVNVGCIPKK 159 Query: 75 ALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTY 134 + + + L + +A+ G DV+ + + D + L G V Y Sbjct: 160 LM-HQAALLNHYMEDAKSFGWDVDKGP-HDWVKMVEGIQDHIHALNFGYRSSMMNANVKY 217 Query: 135 YKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSS 194 G D I+ T G+ + + IIVATG +P I +E ++S Sbjct: 218 LNALGEIVDPHTIKTTNKQGIVKNITTN------TIIVATGERPR-YPPIPGAKEYGITS 270 Query: 195 TGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKF 254 +L P + +G + LE S +G VTV+ D ++A + Sbjct: 271 DDLFTLDHNPGKTLCVGASYVSLECAGFLSSIGCDVTVMVR-SIFLRGFDQQMAGLISDY 329 Query: 255 LKKQGLDFKLSTKVISAK--RNDDKNVVEIVVEDTK----TNKQENLEAEVLLVAVGRRP 308 + K G+ F S + D ++ + + + +L AVGR P Sbjct: 330 IAKYGVKFVRPCVPTSVRCLEEYDPESGKLAIYEVEGKHEDGTPFKDTFNTVLFAVGRDP 389 Query: 309 YIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDV-TFGPMLAHKAEEEGIAAVEM 367 +G + + ++ GR+V+DD+ + P+I +GDV G L A + G Sbjct: 390 CTTNIGLQNVDVKTT-NGRVVVDDEERTNVPNIYAIGDVSNAGYQLTPLAIQAGKNLARR 448 Query: 368 LKTGHG-HVNYNNIPSVMYSHPEVAWVGKTEE----QLKEAGIDYKIGKF-PFAANSRAK 421 L T +Y N+P+ +++ E +G +EE + E I+ F P + Sbjct: 449 LYTADDCRTDYTNVPTTVFTPLEYGCIGLSEENAISKFGEDNIEVFHSYFQPLEWTVPHR 508 Query: 422 TNQDTEGFVKILIDS-KTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPT 480 D + K++I+ R++G H+ GPNAGE+ +A+ GA ED R HPT Sbjct: 509 --PDNTCYAKLIINKQDDNRVVGFHVFGPNAGEVTQGYAVAMHLGARKEDFDRTIGIHPT 566 Query: 481 LSEAFKEAN 489 SE F Sbjct: 567 CSETFTTLR 575 >4DNA-A nrPDB Length = 463 Score = 410 bits (1053), Expect = e-114, Method: Composition-based stats. Identities = 110/468 (23%), Positives = 207/468 (44%), Gaps = 20/468 (4%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQM 86 +D+ +IGGG G + AA LG A E+ + GGTC+ GC+P K + S Sbjct: 6 YDLFVIGGGSGGVRSGRLAAALGKKVAIAEEF-RYGGTCVIRGCVPKKLYVYASQFAEHF 64 Query: 87 HTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETK 146 +A G V G+ + + A AK+ + +L G Sbjct: 65 -EDAAGFGWTV-GESRFDWAKLVAAKEQEIARLEGLYRKGLANAGAEILDTRAELAGPNT 122 Query: 147 IRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKR 206 +++ + + + I++A G +P + E ++S A L +P+ Sbjct: 123 VKL---------LASGKTVTAERIVIAVGGHPSPHDALP-GHELCITSNEAFDLPALPES 172 Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLST 266 + I GGG I +E +++ LG K T++ +I + D ++ + ++++G+ Sbjct: 173 ILIAGGGYIAVEFANIFHGLGVKTTLIYRGKEILSRFDQDMRRGLHAAMEEKGIRILCED 232 Query: 267 KVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRG 326 + S + D V T K + A+ +++A+GR P GLG E G+ ++ G Sbjct: 233 IIQSVSADADGRRV------ATTMKHGEIVADQVMLALGRMPNTNGLGLEAAGVRTNELG 286 Query: 327 RLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEM-LKTGHGHVNYNNIPSVMY 385 +++D + P I +GDVT L A E + +E K +++ I + ++ Sbjct: 287 AIIVDAFSRTSTPGIYALGDVTDRVQLTPVAIHEAMCFIETEYKNNPTSPDHDLIATAVF 346 Query: 386 SHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAH 445 S PE+ VG TEE+ + ++ + F + + + +K+++++ +++GAH Sbjct: 347 SQPEIGTVGITEEEAARKFQEIEVYRAEFRPMKATLSGRKEKTIMKLVVNAADRKVVGAH 406 Query: 446 IIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAY 493 I+G +AGEM G++L G + +D R HPT +E +Y Sbjct: 407 ILGHDAGEMAQLLGISLRAGCTKDDFDRTMAVHPTAAEELVTMYQPSY 454 >3II4-A nrPDB Length = 466 Score = 401 bits (1030), Expect = e-112, Method: Composition-based stats. Identities = 171/478 (35%), Positives = 248/478 (51%), Gaps = 16/478 (3%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHL 82 +DVV++G GP GYVAAI+AAQLG +TA VE + GG CLNVGCIPSKALL N+ L Sbjct: 2 SMTHYDVVVLGAGPGGYVAAIRAAQLGLSTAIVEPK-YWGGVCLNVGCIPSKALLRNAEL 60 Query: 83 FHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFE 142 H +A+ GI G++ + + G+ L KKNK+T G G+F Sbjct: 61 VHIFTKDAKAFGIS--GEVTFDYGIAYDRSRKVAEGRVAGVHFLMKKNKITEIHGYGTFA 118 Query: 143 DETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKE 202 D + V DG +V D N I+ATGS PG + +V+ + +E Sbjct: 119 DANTLLVDLNDGGTESVTFD------NAIIATGSSTRLVPGTSLSAN-VVTYEEQILSRE 171 Query: 203 IPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDF 262 +PK + I G G IG+E G V G VT+VEF P+ + D +V+K +K KK G+ Sbjct: 172 LPKSIIIAGAGAIGMEFGYVLKNYGVDVTIVEFLPRALPNEDADVSKEIEKQFKKLGVTI 231 Query: 263 KLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEV 322 +TKV S ++ V TK + L+AE +L A+G P + G G +K G+ + Sbjct: 232 LTATKVESIADGGS----QVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVAL 287 Query: 323 DKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHV--NYNNI 380 R + +DD + HI +GDV LAH AE +G+ A E + ++ + Sbjct: 288 TDRKAIGVDDYMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTLGDHRML 347 Query: 381 PSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTER 440 P + P VA G TE+Q + G D + KFPF AN++A D GFVK++ D+K Sbjct: 348 PRATFCQPNVASFGLTEQQARNEGYDVVVAKFPFTANAKAHGVGDPSGFVKLVADAKHGE 407 Query: 441 ILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKAIH 498 +LG H++G + E++ E LA + +A ++AR H HPT+SEA +E I+ Sbjct: 408 LLGGHLVGHDVAELLPELTLAQRWDLTASELARNVHTHPTMSEALQECFHGLVGHMIN 465 >1ONF-A nrPDB Length = 500 Score = 399 bits (1026), Expect = e-111, Method: Composition-based stats. Identities = 130/505 (25%), Positives = 221/505 (43%), Gaps = 61/505 (12%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQM 86 +D+++IGGG G AA +AA+ A VEK +LGGTC+NVGC+P K + N + + H + Sbjct: 3 YDLIVIGGGSGGMAAARRAARHNAKVALVEK-SRLGGTCVNVGCVPKKIMFNAASV-HDI 60 Query: 87 HTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETK 146 ++ G D N+ + +D +++L K+KV Y+G SF E + Sbjct: 61 LENSRHYGFDT--KFSFNLPLLVERRDKYIQRLNNIYRQNLSKDKVDLYEGTASFLSENR 118 Query: 147 IRVTP---VDGLEGTVKEDHILDVKNIIVATGSEV--TPFPGIEIDEEKIVSSTGALSLK 201 I + + + + IL+ +NI++A G++ P GIE +SS ++K Sbjct: 119 ILIKGTKDNNNKDNGPLNEEILEGRNILIAVGNKPVFPPVKGIEN----TISSDEFFNIK 174 Query: 202 EIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLD 261 E K++ I+G G I +E+ +V RLG + +I D V + +KK ++ Sbjct: 175 E-SKKIGIVGSGYIAVELINVIKRLGIDSYIFARGNRILRKFDESVINVLENDMKKNNIN 233 Query: 262 FKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLE 321 V+ K+ DKN + I + D + + + ++ VGR P L EK+ +E Sbjct: 234 IVTFADVVEIKKVSDKN-LSIHLSDGRIYEH----FDHVIYCVGRSPDTENLKLEKLNVE 288 Query: 322 VDKRGRLVIDDQFNSKFPHIKVVGDVT--------------------------------- 348 + +V+D+ + +I VGD Sbjct: 289 TN-NNYIVVDENQRTSVNNIYAVGDCCMVKKSKEIEDLNLLKLYNEERYLNKKENVTEDI 347 Query: 349 -FGPMLAHKAEEEGIAAVEMLK-TGHGHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAG-- 404 + L A G + L NY IP+V++SHP + +G +EE + Sbjct: 348 FYNVQLTPVAINAGRLLADRLFLKKTRKTNYKLIPTVIFSHPPIGTIGLSEEAAIQIYGK 407 Query: 405 IDYKIGKFPFA----ANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAEAGL 460 + KI + F + + + ++K++ K E I G HIIG NA E++ + Sbjct: 408 ENVKIYESKFTNLFFSVYDIEPELKEKTYLKLVCVGKDELIKGLHIIGLNADEIVQGFAV 467 Query: 461 ALEYGASAEDVARVCHAHPTLSEAF 485 AL+ A+ +D HPT +E F Sbjct: 468 ALKMNATKKDFDETIPIHPTAAEEF 492 >1OJT-A nrPDB Length = 482 Score = 385 bits (989), Expect = e-107, Method: Composition-based stats. Identities = 179/460 (38%), Positives = 251/460 (54%), Gaps = 10/460 (2%) Query: 39 YVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVN 98 Y AA AA G A VE+ LGG CLNVGCIPSKALL+N+ + ++ A GI Sbjct: 19 YSAAFAAADEGLKVAIVERYKTLGGVCLNVGCIPSKALLHNAAVIDEVRHLAAN-GIKY- 76 Query: 99 GDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDG---- 154 + ++++ + KD V +LTGG+ + K KV +G+G F D + V+ G Sbjct: 77 PEPELDIDMLRAYKDGVVSRLTGGLAGMAKSRKVDVIQGDGQFLDPHHLEVSLTAGDAYE 136 Query: 155 LEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGI 214 E I+ KN I+A GS VT P I D +I+ S+GAL+LKE+P +L IIGGGI Sbjct: 137 QAAPTGEKKIVAFKNCIIAAGSRVTKLPFIPED-PRIIDSSGALALKEVPGKLLIIGGGI 195 Query: 215 IGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRN 274 IGLEMG+VYS LGS++ VVE + D ++ K QK + + + ++TK ++ + Sbjct: 196 IGLEMGTVYSTLGSRLDVVEMMDGLMQGADRDLVKVWQKQNEYRFDNIMVNTKTVAVEPK 255 Query: 275 DDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQF 334 +D V + +E + +LVA GR P + AEK G+ V RG + +D Q Sbjct: 256 EDGVYVTF---EGANAPKEPQRYDAVLVAAGRAPNGKLISAEKAGVAVTDRGFIEVDKQM 312 Query: 335 NSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYSHPEVAWVG 394 + PHI +GD+ PMLAHKA EG A E + + IP V Y+ PEVAWVG Sbjct: 313 RTNVPHIYAIGDIVGQPMLAHKAVHEGHVAAENCAGHKAYFDARVIPGVAYTSPEVAWVG 372 Query: 395 KTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEM 454 +TE K + FP+AA+ RA N + F K++ D++T RI+G I+GPN G+M Sbjct: 373 ETELSAKASARKITKANFPWAASGRAIANGCDKPFTKLIFDAETGRIIGGGIVGPNGGDM 432 Query: 455 IAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYD 494 I E LA+E G A D+ + H HPTL E+ A A Sbjct: 433 IGEVCLAIEMGCDAADIGKTIHPHPTLGESIGMAAEVALG 472 >5U25-A nrPDB Length = 602 Score = 381 bits (979), Expect = e-106, Method: Composition-based stats. Identities = 181/460 (39%), Positives = 252/460 (54%), Gaps = 10/460 (2%) Query: 39 YVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVN 98 Y AA AA G A VE+ LGG CLNVGCIPSKALL+N+ + ++ A GI Sbjct: 138 YSAAFAAADEGLKVAIVERYKTLGGVCLNVGCIPSKALLHNAAVIDEVRHLAAN-GIKY- 195 Query: 99 GDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDG---- 154 + ++++ + KD V +LTGG+ + K KV +G+G F D + V+ G Sbjct: 196 PEPELDIDMLRAYKDGVVSRLTGGLAGMAKSRKVDVIQGDGQFLDPHHLEVSLTAGDAYE 255 Query: 155 LEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGI 214 E I+ KN I+A GS VT P I D +I+ S+GAL+LKE+P +L IIGGGI Sbjct: 256 QAAPTGEKKIVAFKNCIIAAGSRVTKLPFIPED-PRIIDSSGALALKEVPGKLLIIGGGI 314 Query: 215 IGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRN 274 IGLEMG+VYS LGS++ VVE + D ++ K QK + + + ++TK ++ + Sbjct: 315 IGLEMGTVYSTLGSRLDVVEMMDGLMQGADRDLVKVWQKQNEYRFDNIMVNTKTVAVEPK 374 Query: 275 DDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQF 334 +D V + +E + +LVA GR P + AEK G+ V RG + +D Q Sbjct: 375 EDGVYVTF---EGANAPKEPQRYDAVLVAAGRAPNGKLISAEKAGVAVTDRGFIEVDKQM 431 Query: 335 NSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYSHPEVAWVG 394 + PHI +GD+ PMLAHKA EG A E + + IP V Y+ PEVAWVG Sbjct: 432 RTNVPHIYAIGDIVGQPMLAHKAVHEGHVAAENCAGHKAYFDARVIPGVAYTSPEVAWVG 491 Query: 395 KTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEM 454 +TE K +G FP+AA+ RA N GF K++ D++T RI+G I+GPN G+M Sbjct: 492 ETELSAKASGRKITKANFPWAASGRAIANGCDNGFTKLIFDAETGRIIGGGIVGPNGGDM 551 Query: 455 IAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYD 494 I E LA+E G A D+ + H HPTL E+ A A Sbjct: 552 IGEVCLAIEMGCDAADIGKTIHPHPTLGESIGMAAEVALG 591 >4YWO-A nrPDB Length = 462 Score = 375 bits (962), Expect = e-104, Method: Composition-based stats. Identities = 130/470 (27%), Positives = 228/470 (48%), Gaps = 38/470 (8%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQ 85 H + IIG G AG+ A IKA +LG + +G++GGTC+NVGC+PSK +L + ++ + Sbjct: 15 MHKLAIIGYGAAGFAAMIKANELGVKPVLI-GKGEIGGTCVNVGCVPSKRMLYIAEIYKK 73 Query: 86 MHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGG-IELLFKKNKVTYYKGNGSFEDE 144 ++ ++FQ+ KD V+++ E L V +G F Sbjct: 74 ARE-------VTGSEVYPPFSSFQE-KDGLVQEMRKTKYEDLLSYYDVELIQGEARFISP 125 Query: 145 TKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEV--TPFPGIEIDEEKIVSSTGALSLKE 202 ++V +++ + ++ATGS PG +D+ ++ ALS Sbjct: 126 HAVKVN-----------GQVIEAEKFVIATGSSPLIPRIPG--LDKVGFWTNREALSPDR 172 Query: 203 IPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDF 262 L +IGG + LE +YSR+ +V +++ P + + E + ++ ++ G+ Sbjct: 173 RIDSLAVIGGRALALEFAQMYSRMKVEVAILQRSPVLIPDWEPEASVEARRIMENDGVAV 232 Query: 263 KLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEV 322 V ++ K V+ + +EA+ +L+A GR+P + LG E G+ + Sbjct: 233 VTGVNVKEVRKGAGKIVIT---------DKGEVEADEILLATGRKPNVD-LGLENAGVRL 282 Query: 323 DKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEM-LKTGHGHVNYNNIP 381 ++RG + +DD+ + PHI GDV G ML A +G A E L H V+ N +P Sbjct: 283 NERGGIKVDDELRTDNPHIYAAGDVLGGKMLEALAGRQGSIATENALTGSHKRVDENAVP 342 Query: 382 SVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERI 441 V+++ P +A VG TE + + + + P ++ ++A+ GFVK++ RI Sbjct: 343 QVIFTQPNLARVGLTEAEARAKEGEVEARVLPMSSVAKAEIINSRLGFVKMVT--MNGRI 400 Query: 442 LGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMA 491 +G H +G N EMI EA LA+ +GA+ D+ H PT++E+ + +A Sbjct: 401 VGVHAVGENVAEMIGEAALAIRFGATVHDLIDTVHMFPTIAESLRLVALA 450 >1ZK7-A nrPDB Length = 467 Score = 355 bits (910), Expect = 3e-98, Method: Composition-based stats. Identities = 138/465 (29%), Positives = 221/465 (47%), Gaps = 23/465 (4%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHT 88 V +IG G A AA+KA + G +E RG +GGTC+NVGC+PSK ++ +H+ H + Sbjct: 7 VAVIGSGGAAMAAALKAVEQGAQVTLIE-RGTIGGTCVNVGCVPSKIMIRAAHIAH-LRR 64 Query: 89 EAQKRGIDVNGDIKINVANFQKAKDDAVKQL-TGGIELLFKKNK-VTYYKGNGSFEDETK 146 E+ G I+ + + V +L E + N +T G F+D+ Sbjct: 65 ESPFDGGIAATVPTIDRSKLLAQQQARVDELRHAKYEGILGGNPAITVVHGEARFKDDQS 124 Query: 147 IRVTPVDGLEGTVKEDHILDVKNIIVATGSEV--TPFPGIEIDEEKIVSSTGALSLKEIP 204 + V +G E V D L VATG+ P PG++ E +ST AL+ IP Sbjct: 125 LTVRLNEGGERVVMFDRCL------VATGASPAVPPIPGLK--ESPYWTSTEALASDTIP 176 Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKL 264 +RL +IG ++ LE+ ++RLGSKVTV+ + D + +A + +G++ Sbjct: 177 ERLAVIGSSVVALELAQAFARLGSKVTVLAR-NTLFFREDPAIGEAVTAAFRAEGIEVLE 235 Query: 265 STKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDK 324 T+ D + V+ T L A+ LLVA GR P L + G+ V+ Sbjct: 236 HTQASQVAHMDGEFVL--------TTTHGELRADKLLVATGRTPNTRSLALDAAGVTVNA 287 Query: 325 RGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVM 384 +G +VID + P+I GD T P + A G A + G ++ +P+V+ Sbjct: 288 QGAIVIDQGMRTSNPNIYAAGDCTDQPQFVYVAAAAGTRAAINMTGGDAALDLTAMPAVV 347 Query: 385 YSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGA 444 ++ P+VA VG +E + GI+ RA N DT GF+K++I+ + R++G Sbjct: 348 FTDPQVATVGYSEAEAHHDGIETDSRTLTLDNVPRALANFDTRGFIKLVIEEGSHRLIGV 407 Query: 445 HIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEAN 489 + P AGE+I A LA+ + +++A + T+ E K A Sbjct: 408 QAVAPEAGELIQTAALAIRNRMTVQELADQLFPYLTMVEGLKLAA 452 >3IC9-A nrPDB Length = 492 Score = 311 bits (796), Expect = 6e-85, Method: Composition-based stats. Identities = 118/476 (24%), Positives = 210/476 (44%), Gaps = 38/476 (7%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMH 87 DV IIG G AG A +AA+ + + + G G TC VGC+PSK L+ + + Sbjct: 10 DVAIIGTGTAGM-GAYRAAKKHTDKVVLIEGGAYGTTCARVGCMPSKLLIAAADASYHA- 67 Query: 88 TEAQKRGIDVNG---DIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDE 144 ++ GI V+ + K + Q +D V + +E +++K+ +G F DE Sbjct: 68 SQTDLFGIQVDRISVNGKAVMKRIQTERDRFVGFVVESVESFDEQDKI---RGFAKFLDE 124 Query: 145 TKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIP 204 ++V + K I++ATGS + +++++ L ++P Sbjct: 125 HTLQVDDHSQ----------VIAKRIVIATGSRPNYPEFLAAAGSRLLTNDNLFELNDLP 174 Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKL 264 K + + G G+IGLE+G SRLG V V + D E+ + +K ++ F Sbjct: 175 KSVAVFGPGVIGLELGQALSRLGVIVKVFGRSGSVANLQDEEMKRYAEKTFNEE-FYFDA 233 Query: 265 STKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDK 324 +VIS +D VE++ D K+ ++ + +L A GR+ + LG E +E+DK Sbjct: 234 KARVISTIEKED--AVEVIYFD-KSGQKTTESFQYVLAATGRKANVDKLGLENTSIELDK 290 Query: 325 RGRLVIDD-QFNSKFPHIKVVGDVTFGPMLAHKAEEEGIA------AVEMLKTGHGHVNY 377 + + D+ + HI V GD L H+A ++G A ++ G Sbjct: 291 KNSPLFDELTLQTSVDHIFVAGDANNTLTLLHEAADDGKVAGTNAGAYPVIAQGQRRAPL 350 Query: 378 NNIPSVMYSHPEVAWVGKTEEQLKEAGID-----YKIGKFPFAANSRAKTNQDTEGFVKI 432 SV+++ P+VA VG + Q+++ D Y +G+ F R++ +G + + Sbjct: 351 ----SVVFTEPQVASVGLSLRQIEDLYADQDAANYVVGQVSFEGQGRSRVMGKNKGLLNV 406 Query: 433 LIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEA 488 D + LGA + GP A + A + + + + + HP + E + A Sbjct: 407 YADRTSGEFLGAEMFGPAAEHIGHLLAWARQQQMTVQAMLTMPFYHPVIEEGLRTA 462 >1XDI-A nrPDB Length = 499 Score = 308 bits (789), Expect = 4e-84, Method: Composition-based stats. Identities = 113/472 (23%), Positives = 196/472 (41%), Gaps = 12/472 (2%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVE--KRGKLGGTCLNVGCIPSKALLNNSHLFHQM 86 +VI+GGGPAGY AA+ AA T V +GG + C+PSK + ++ L ++ Sbjct: 5 IVILGGGPAGYEAALVAATSHPETTQVTVIDCDGIGGAAVLDDCVPSKTFIASTGLRTEL 64 Query: 87 HTEAQKRGIDVN-GDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDET 145 A G ++ D KI++ + I V G G D T Sbjct: 65 RR-APHLGFHIDFDDAKISLPQIHARVKTLAAAQSADITAQLLSMGVQVIAGRGELIDST 123 Query: 146 KIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPK 205 + ++VATG+ P + D E+I++ L +P Sbjct: 124 PGLARHRIKATAADGSTSEHEADVVLVATGASPRILPSAQPDGERILTWRQLYDLDALPD 183 Query: 206 RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLS 265 L ++G G+ G E Y+ LG VTVV Q + D + A ++ ++G+ + Sbjct: 184 HLIVVGSGVTGAEFVDAYTELGVPVTVVASQDHVLPYEDADAALVLEESFAERGVRLFKN 243 Query: 266 TKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKR 325 + S R V + + D +T + L+ +G P +GLG E++G+++ + Sbjct: 244 ARAASVTRTGAG--VLVTMTDGRTVEGS-----HALMTIGSVPNTSGLGLERVGIQLGRG 296 Query: 326 GRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAA-VEMLKTGHGHVNYNNIPSVM 384 L +D + I GD T LA A +G A L G + + + + Sbjct: 297 NYLTVDRVSRTLATGIYAAGDCTGLLPLASVAAMQGRIAMYHALGEGVSPIRLRTVAATV 356 Query: 385 YSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGA 444 ++ PE+A VG + + + + P N+RAK ++ GFVKI T ++G Sbjct: 357 FTRPEIAAVGVPQSVIDAGSVAARTIMLPLRTNARAKMSEMRHGFVKIFCRRSTGVVIGG 416 Query: 445 HIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAYDKA 496 ++ P A E+I +A++ + ++A+ +P+LS + EA Sbjct: 417 VVVAPIASELILPIAVAVQNRITVNELAQTLAVYPSLSGSITEAARRLMAHD 468 >3L8K-A nrPDB Length = 466 Score = 302 bits (774), Expect = 2e-82, Method: Composition-based stats. Identities = 126/479 (26%), Positives = 231/479 (48%), Gaps = 37/479 (7%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHL 82 ++ +DVV+IG G AGY A + A+ +N + +G+LGG CL GC+PSK Sbjct: 1 MSLKYDVVVIGAGGAGYHGAFRLAKAKYNVLMADPKGELGGNCLYSGCVPSKT------- 53 Query: 83 FHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGG--IELLFKKNKVTYYKGNGS 140 ++ A + N I ++ + Q KD V++L + + +T+YKG Sbjct: 54 VREVIQTAWRLTNIANVKIPLDFSTVQDRKD-YVQELRFKQHKRNMSQYETLTFYKGYVK 112 Query: 141 FEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEV--TPFPGIEIDEEKIVSSTGAL 198 +D T + V +G E + + +I+A+G+E PG+E ++S Sbjct: 113 IKDPTHVIVKTDEGKEIEA------ETRYMIIASGAETAKLRLPGVE----YCLTSDDIF 162 Query: 199 ----SLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASM-DGEVAKATQK 253 S +++P+ + IIG G IGLE+ S++ +G + ++E + ++ D ++ Sbjct: 163 GYKTSFRKLPQDMVIIGAGYIGLEIASIFRLMGVQTHIIEMLDRALITLEDQDIVNTLLS 222 Query: 254 FLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGL 313 LK L+ K ++ V K+ D V+ TK ++++ +++A GRRP I Sbjct: 223 ILK---LNIKFNSPVTEVKKIKDDEYE--VIYSTKDGSKKSIFTNSVVLAAGRRPVIPE- 276 Query: 314 GAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHG 373 GA +IGL + K G +V+D+ + P++ GD H A IAA + Sbjct: 277 GAREIGLSISKTG-IVVDETMKTNIPNVFATGDANGLAPYYHAAVRMSIAAANNIMANGM 335 Query: 374 HVNY---NNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFV 430 V+Y +IP +Y+ P +++VG + ++ GI+ ++ + A+ EG + Sbjct: 336 PVDYVDVKSIPVTIYTIPSLSYVGILPSKARKMGIEIVEAEYNMEEDVSAQIYGQKEGVL 395 Query: 431 KILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEAN 489 K++ + + R++GA +IG ++ +I E GLA+ YG +A+ +A HP+ +E Sbjct: 396 KLIFERGSMRLIGAWMIGVHSQYLINELGLAVAYGLNAKQLASFAEQHPSTNEIISYTA 454 >3Q6J-A nrPDB Length = 523 Score = 283 bits (724), Expect = 1e-76, Method: Composition-based stats. Identities = 105/486 (21%), Positives = 207/486 (42%), Gaps = 52/486 (10%) Query: 25 KSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFH 84 + +D + IGGG AG + +G V++ LGG+C + C+P HLF Sbjct: 42 REYDAIFIGGGAAGRFGSAYLRAMGGRQLIVDRWPFLGGSCPHNACVPH-------HLFS 94 Query: 85 QMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIEL--LFKKNKVTYYKGNGSFE 142 E + + Q D +++ G E+ LF+ + G +F+ Sbjct: 95 DCAAEL----------MLARTFSGQYWFPDMTEKVVGIKEVVDLFRAGRNGP-HGIMNFQ 143 Query: 143 DETKIRVTPVDGLEGTVKEDHILDV-------KNIIVATGSEV--TPFPGIEIDEEKIVS 193 + ++ + + V ++H ++ KN+I+A G+ PG+ + Sbjct: 144 SKEQLNLEYILNCPAKVIDNHTVEAAGKVFKAKNLILAVGAGPGTLDVPGVN-AKGVFDH 202 Query: 194 STGALSLKEIPKR-LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQ 252 +T L P + ++GG +E G ++ G + ++ + D E Sbjct: 203 ATLVEELDYEPGSTVVVVGGSKTAVEYGCFFNATGRRTVMLVRTEPLKLIKDNETRAYVL 262 Query: 253 KFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAG 312 +K+QG++ + V + + + V +V N + +E + + + +G +P A Sbjct: 263 DRMKEQGMEIISGSNVTRIEEDANGRVQAVVA--MTPNGEMRIETDFVFLGLGEQPRSAE 320 Query: 313 LGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGH 372 L A+ +GL++ +G +++++ + P++ VGD+ GPM KA + G A + Sbjct: 321 L-AKILGLDLGPKGEVLVNEYLQTSVPNVYAVGDLIGGPMEMFKARKSGCYAARNVMGEK 379 Query: 373 GHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFP----------FAANSR--- 419 N P +++H EV+++G EE+ + AG + K P A+ R Sbjct: 380 ISYTPKNYPDFLHTHYEVSFLGMGEEEARAAGHEIVTIKMPPDTENGLNVALPASDRTML 439 Query: 420 ---AKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARV-- 474 K GF KI+ID+KT ++LGAH +G A + + ++ G + +++ + Sbjct: 440 YAFGKGTAHMSGFQKIVIDAKTRKVLGAHHVGYGAKDAFQYLNVLIKQGLTVDELGDMDE 499 Query: 475 CHAHPT 480 +PT Sbjct: 500 LFLNPT 505 >2BC1-A nrPDB Length = 490 Score = 221 bits (563), Expect = 6e-58, Method: Composition-based stats. Identities = 88/475 (18%), Positives = 168/475 (35%), Gaps = 52/475 (10%) Query: 56 EKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDA 115 + + + G + VG A + M T V D N++ Sbjct: 29 DDKDRWGSKIVVVG-----ANHAGTACIKTMLTNYGDANEIVVFDQNSNISFLGSGMALW 83 Query: 116 VKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTV---KEDHILDVKNIIV 172 + + G E LF +K E+ ++ D T ++H+ +I Sbjct: 84 IGEQIAGPEGLFYSDKEELESLGAKVYMESPVQSIDYDAKTVTALVDGKNHVETYDKLIF 143 Query: 173 ATGSEV--TPFPGIE-----IDEEKIVSSTGALSLKEIP------------KRLTIIGGG 213 ATGS+ P G E ++ E + + + L + KR+ ++G G Sbjct: 144 ATGSQPILPPIKGAEIKEGSLEFEATLENLQFVKLYQNSADVIAKLENKDIKRVAVVGAG 203 Query: 214 IIGLEMGSVYSRLGSKVTVVEFQPQIGASM-DGEVAKATQKFLKKQGLDFKLSTKVISAK 272 IG+E+ + R G +V +++ A D ++ K +++ G+ V Sbjct: 204 YIGVELAEAFQRKGKEVVLIDVVDTCLAGYYDRDLTDLMAKNMEEHGIQLAFGETVKEVA 263 Query: 273 RNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDD 332 N VE ++ D + + +++++AVG RP +++ + G +++ Sbjct: 264 GNGK---VEKIITD-----KNEYDVDMVILAVGFRPNTT---LGNGKIDLFRNGAFLVNK 312 Query: 333 QFNSKFPHIKVVGDV----------TFGPMLAHKAEEEGIAAVEMLKTGHGH-VNYNNIP 381 + + P + +GD T LA A GI A + Sbjct: 313 RQETSIPGVYAIGDCATIYDNATRDTNYIALASNAVRTGIVAAHNACGTDLEGIGVQGSN 372 Query: 382 SVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERI 441 + + G T E+ K G D + ++ + + +KI+ D + RI Sbjct: 373 GISIYGLHMVSTGLTLEKAKRLGFDAAVTEYTDNQKPEFIEHGNFPVTIKIVYDKDSRRI 432 Query: 442 LGAHIIGPNAGEM-IAEAGLALEYGASAEDVARV-CHAHPTLSEAFKEANMAAYD 494 LGA + M I LA++ G + E +A P ++ + MAA Sbjct: 433 LGAQMAAREDVSMGIHMFSLAIQEGVTIEKLALTDIFFLPHFNKPYNYITMAALG 487 >3CGD-A nrPDB Length = 480 Score = 214 bits (545), Expect = 9e-56, Method: Composition-based stats. Identities = 92/410 (22%), Positives = 162/410 (39%), Gaps = 48/410 (11%) Query: 115 AVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHI-------LDV 167 + E L +N T+ G + + + VT VD + V +H Sbjct: 83 VISGAIASTEKLIARNVKTFRDKYG-IDAKVRHEVTKVDTEKKIVYAEHTKTKDVFEFSY 141 Query: 168 KNIIVATGSEV--TPFPGIEI----------DEEKIVSSTGALSLKEIPKRLTIIGGGII 215 +++ATG + G ++ D E+I+ + +++ +TIIGGG I Sbjct: 142 DRLLIATGVRPVMPEWEGRDLQGVHLLKTIPDAERILKTLETNKVED----VTIIGGGAI 197 Query: 216 GLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRND 275 GLEM + LG KV ++E IG DG++A+ K K ++ + V + K N+ Sbjct: 198 GLEMAETFVELGKKVRMIERNDHIGTIYDGDMAEYIYKEADKHHIEILTNENVKAFKGNE 257 Query: 276 DKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFN 335 VE V D T K A+++LV+VG +P L E + + +G + ++ Sbjct: 258 ---RVEAVETDKGTYK-----ADLVLVSVGVKPNTDFL--EGTNIRTNHKGAIEVNAYMQ 307 Query: 336 SKFPHIKVVGDV----------TFGPMLAHKAEEEGIAA-VEMLKTGHGHVNYNNIPSVM 384 + + GD + A ++G A + ML + Sbjct: 308 TNVQDVYAAGDCATHYHVIKEIHDHIPIGTTANKQGRLAGLNMLDKRRAFKGTLGTGIIK 367 Query: 385 YSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGA 444 + + +A G E++ K I YK K + N ++K+L S T+++LG Sbjct: 368 FMNLTLARTGLNEKEAKGLHIPYKTVKVD-STNMAGYYPNAKPLYLKLLYRSDTKQLLGG 426 Query: 445 HIIGPNAGEM-IAEAGLALEYGASAEDVARVCHAH-PTLSEAFKEANMAA 492 +IG + I +AL S D+ V ++ P + + AA Sbjct: 427 QVIGEEGVDKRIDVIAMALFNKMSIHDLEDVDLSYAPPYNSVWDPIQQAA 476 Score = 44.9 bits (105), Expect = 9e-05, Method: Composition-based stats. Identities = 21/80 (26%), Positives = 34/80 (42%), Gaps = 13/80 (16%) Query: 18 VRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALL 77 ++TL NK DV IIGGG G A +LG +E+ +G + Sbjct: 178 LKTLETNKVEDVTIIGGGAIGLEMAETFVELGKKVRMIERNDHIG-------------TI 224 Query: 78 NNSHLFHQMHTEAQKRGIDV 97 + + ++ EA K I++ Sbjct: 225 YDGDMAEYIYKEADKHHIEI 244 >5ER0-A nrPDB Length = 518 Score = 213 bits (542), Expect = 2e-55, Method: Composition-based stats. Identities = 80/440 (18%), Positives = 157/440 (35%), Gaps = 50/440 (11%) Query: 88 TEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGI-----------ELLFKKNKVTYYK 136 T A I + ++D + L+ GI + LF + K Sbjct: 59 THAGTFAIKQILAEHPDAEVTVYERNDVISFLSCGIALYLGGKVADPQGLFYSSPEELQK 118 Query: 137 GNGSFEDETKIRVTPVDGLEGTVKE-----DHILDVKNIIVATGSEV--TPFPGIEIDEE 189 + + + D TV++ +++ +GS PGI+ D Sbjct: 119 LGANVQMNHNVLAIDPDQKTVTVEDLTNHAQTTESYDKLVMTSGSWPIVPKIPGIDSDRV 178 Query: 190 KIVSSTG----ALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGA-SMD 244 K+ + + + KR+T+IG G IG E+ YS G VT+++ ++ D Sbjct: 179 KLCKNWAHAQALIEDAKEAKRITVIGAGYIGAELAEAYSTTGHDVTLIDAMARVMPKYFD 238 Query: 245 GEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAV 304 + ++ + G+ L V S + ++ + + E ++ ++ + Sbjct: 239 ADFTDVIEQDYRDHGVQLALGETVESFTDSATGLTIK--------TDKNSYETDLAILCI 290 Query: 305 GRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGD---VTFGP-------MLA 354 G RP L K +++ G ++ DD S P I GD V + P LA Sbjct: 291 GFRPNTDLL---KGKVDMAPNGAIITDDYMRSSNPDIFAAGDSAAVHYNPTHQNAYIPLA 347 Query: 355 HKAEEEGIAAVEMLKT-GHGHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFP 413 A +GI + L ++ + + + G T K+ G++ + + Sbjct: 348 TNAVRQGILVGKNLVKPTVKYMGTQSSSGLALYDRTIVSTGLTLAAAKQQGLNAE--QVI 405 Query: 414 FAANSRAKTNQDT-EGFVKILIDSKTERILGAHIIG-PNAGEMIAEAGLALEYGASAEDV 471 N R + T + ++ D T RILG ++ + + + ++ + +D+ Sbjct: 406 VEDNYRPEFMPSTEPVLMSLVFDPDTHRILGGALMSKYDVSQSANTLSVCIQNENTIDDL 465 Query: 472 ARV-CHAHPTLSEAFKEANM 490 A V P F N+ Sbjct: 466 AMVDMLFQPNFDRPFNYLNI 485 >3ICS-A nrPDB Length = 588 Score = 209 bits (533), Expect = 2e-54, Method: Composition-based stats. Identities = 76/363 (20%), Positives = 144/363 (39%), Gaps = 37/363 (10%) Query: 155 LEGTVKEDHILDVKNIIVATGSEV--TPFPGIEIDEEKIV-------SSTGALSLKEIPK 205 T E + +I++ G++ PGIE + A ++ P+ Sbjct: 129 KNVTTNETYNEAYDVLILSPGAKPIVPSIPGIEEAKALFTLRNVPDTDRIKAYIDEKKPR 188 Query: 206 RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLS 265 T+IGGG IG+EM G +VT+VE Q+ +D E+A + +K ++ Sbjct: 189 HATVIGGGFIGVEMVENLRERGIEVTLVEMANQVMPPIDYEMAAYVHEHMKNHDVELVFE 248 Query: 266 TKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKR 325 V + + N ++ ++ ++L++A+G +P + A+ GL + R Sbjct: 249 DGVDALEENGAVVRLK---------SGSVIQTDMLILAIGVQPESS--LAKGAGLALGVR 297 Query: 326 GRLVIDDQFNSKFPHIKVVGDVTFG----------PMLAHKAEEEGIAAVEMLKTGHG-- 373 G + ++++F + PHI +GD LA A +G +++ Sbjct: 298 GTIKVNEKFQTSDPHIYAIGDAIEVKDFVTETETMIPLAWPANRQGRMLADIIHGHTDSL 357 Query: 374 HVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRA-KTNQDTEGFVKI 432 + VA G E+ LK I Y++ ANS A T +K+ Sbjct: 358 YKGTLGTSVAKVFDLTVATTGLNEKILKRLNIPYEV--VHVQANSHAGYYPNATPVLIKL 415 Query: 433 LIDSKTERILGAHIIGPNAGEMIAE-AGLALEYGASAEDVARVCHAH-PTLSEAFKEANM 490 + + + +I GA +G + + + A++ + D+ + ++ P S A NM Sbjct: 416 IFNKDSGKIYGAQTLGRDGVDKRMDVIATAIKANLTVLDLPDLELSYAPPYSSAKDPVNM 475 Query: 491 AAY 493 Y Sbjct: 476 VGY 478 >1NHQ-A nrPDB Length = 447 Score = 204 bits (520), Expect = 6e-53, Method: Composition-based stats. Identities = 85/411 (20%), Positives = 160/411 (38%), Gaps = 40/411 (9%) Query: 108 FQKAKDDAVKQLTGGIELLFKKNKVTYY-KGNGSFEDETKIRVTPVDGLEGTVKEDHILD 166 + + K V + + V + + + +VT D + G E+ + + Sbjct: 47 YLEGKVKDVNSVRYMTGEKMESRGVNVFSNTEITAIQPKEHQVTVKDLVSG---EERVEN 103 Query: 167 VKNIIVATGSEV--TPFPGIEIDEEKIVSST-GALSLKEIP-----KRLTIIGGGIIGLE 218 +I++ G+ PG ++D ++ A+ LK+ + +IG G IG+E Sbjct: 104 YDKLIISPGAVPFELDIPGKDLDNIYLMRGRQWAIKLKQKTVDPEVNNVVVIGSGYIGIE 163 Query: 219 MGSVYSRLGSKVTVVEFQPQIGA-SMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDK 277 +++ G KVTV++ + +D E + ++ + V +R + Sbjct: 164 AAEAFAKAGKKVTVIDILDRPLGVYLDKEFTDVLTEEMEANNITIATGETV---ERYEGD 220 Query: 278 NVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSK 337 V+ VV D +A++++VAVG RP A L K LE+ G + D+ + Sbjct: 221 GRVQKVVTDKNA-----YDADLVVVAVGVRPNTAWL---KGTLELHPNGLIKTDEYMRTS 272 Query: 338 FPHIKVVGDVTF----------GPMLAHKAEEEGIAAVEMLKTGHGHV-NYNNIPSVMYS 386 P + VGD T LA A ++G AV+ L+ + Sbjct: 273 EPDVFAVGDATLIKYNPADTEVNIALATNARKQGRFAVKNLEEPVKPFPGVQGSSGLAVF 332 Query: 387 HPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQD-TEGFVKILIDSKTERILGAH 445 + A G E ++ G + K + N D + + K++ D +T +ILGA Sbjct: 333 DYKFASTGINEVMAQKLGKETKA--VTVVEDYLMDFNPDKQKAWFKLVYDPETTQILGAQ 390 Query: 446 IIGP-NAGEMIAEAGLALEYGASAEDVARV-CHAHPTLSEAFKEANMAAYD 494 ++ + I LA++ + ED+A P + + N AA + Sbjct: 391 LMSKADLTANINAISLAIQAKMTIEDLAYADFFFQPAFDKPWNIINTAALE 441 Score = 33.4 bits (75), Expect = 0.23, Method: Composition-based stats. Identities = 11/36 (30%), Positives = 16/36 (44%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGT 64 VV+IG G G AA A+ G ++ + G Sbjct: 152 VVVIGSGYIGIEAAEAFAKAGKKVTVIDILDRPLGV 187 >3OC4-A nrPDB Length = 452 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 82/444 (18%), Positives = 165/444 (37%), Gaps = 43/444 (9%) Query: 73 SKALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTG---GIELLFKK 129 S A ++ + + + +A+ ID + + + +L E ++ Sbjct: 11 SFAGISAAIASRKKYPQAEISLIDKQATVGYLSGGLSAYFNHTINELHEARYITEEELRR 70 Query: 130 NKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSE--VTPFPGIEID 187 K+ + + ++ E E +I+ATG+ T G + + Sbjct: 71 QKIQLLLNREVVAMDVENQLIAWTRKE----EQQWYSYDKLILATGASQFSTQIRGSQTE 126 Query: 188 E----EKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGA-S 242 + + + + A+ L E + + +IG G IG+E ++ V V E + Sbjct: 127 KLLKYKFLSGALAAVPLLENSQTVAVIGAGPIGMEAIDFLVKMKKTVHVFESLENLLPKY 186 Query: 243 MDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLV 302 D E+ QK L+KQ + F V+ + + V+E ++ + + + Sbjct: 187 FDKEMVAEVQKSLEKQAVIFHFEETVLGIEETANGIVLE--------TSEQEISCDSGIF 238 Query: 303 AVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDV----------TFGPM 352 A+ P +A L +KI +D+ + +D + P++ +GD TF Sbjct: 239 ALNLHPQLAYLD-KKIQRNLDQT--IAVDAYLQTSVPNVFAIGDCISVMNEPVAETFYAP 295 Query: 353 LAHKAEEEGIAAVEML-KTGHGHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGK 411 L + A G+ L + H + +A G TE + G+ + Sbjct: 296 LVNNAVRTGLVVANNLEEKTHRFIGSLRTMGTKVGDYYLASTGLTETE----GLFFPQTL 351 Query: 412 FPFAANSRAKTNQD-TEGFVKILIDSKTERILGAHIIGP-NAGEMIAEAGLALEYGASAE 469 A Q TE K++ D T+R+LGA + N E I L+++ G + Sbjct: 352 ASIIVRQPAPPLQHGTEILGKLIYDKVTQRVLGAQLCSKNNCLEKINTLALSIQTGQTLT 411 Query: 470 DVARVCHAH-PTLSEAFKEANMAA 492 D+ + + + P+L+ + N+ Sbjct: 412 DLLQKDYFYQPSLTNIYDITNLMG 435 >5UWY-A nrPDB Length = 308 Score = 199 bits (506), Expect = 3e-51, Method: Composition-based stats. Identities = 75/331 (22%), Positives = 124/331 (37%), Gaps = 60/331 (18%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLN---VGCIPSKALLNN 79 N +D +IIG GPAG AA+ AA+ + A +E +G GG N + P ++ Sbjct: 1 SNAMYDTLIIGSGPAGMTAALYAARSNLSVAIIE-QGAPGGQMNNTFDIENYPGYDHISG 59 Query: 80 SHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNG 139 L +M+ +K ++ I + NF K Sbjct: 60 PELAMKMYEPLEKFNVENIYGIVQKIENFGDYK--------------------------- 92 Query: 140 SFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGS--EVTPFPGIEIDEEKIVSSTGA 197 + ED + K +I+ATG+ V PG E + VS Sbjct: 93 -----------------CVLTEDASYEAKTVIIATGAKYRVLGVPGEEYYTSRGVSYCAV 135 Query: 198 LS-LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLK 256 + L ++GGG +E ++ KVTVV + Q+ A + + Sbjct: 136 CDGAFFRDQDLLVVGGGDSAVEEAIYLTQFAKKVTVVHRRDQLRAQKILQ-----DRAFA 190 Query: 257 KQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAE 316 +DF + V + ND K V +++E+ KT + + + + VG P + Sbjct: 191 NDKVDFIWDSVVKEIQGNDIK-VSNVLIENVKTGQVTDHAFGGVFIYVGMNPVTGMVKDL 249 Query: 317 KIGLEVDKRGRLVIDDQFNSKFPHIKVVGDV 347 +I D G ++ DD + P I +GDV Sbjct: 250 EI---TDSEGWIITDDHMRTSIPGIFAIGDV 277 >3NTA-A nrPDB Length = 574 Score = 198 bits (504), Expect = 4e-51, Method: Composition-based stats. Identities = 87/401 (21%), Positives = 156/401 (38%), Gaps = 53/401 (13%) Query: 139 GSFEDETKI--RVTPVDGLEGTVKEDHILD-------VKNIIVATGSEV--TPFPGIEI- 186 F E ++ V +D V +LD ++++ G+ P PG++ Sbjct: 69 ARFNVEVRVKHEVVAIDRAAKLVTVRRLLDGSEYQESYDTLLLSPGAAPIVPPIPGVDNP 128 Query: 187 ---------DEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQP 237 D ++I+ + +++ T++GGG IGLEM LG K T++E Sbjct: 129 LTHSLRNIPDMDRILQTIQMNNVE----HATVVGGGFIGLEMMESLHHLGIKTTLLELAD 184 Query: 238 QIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQ----- 292 Q+ +D E+A + ++ QG+D +L T + +V + ++ Sbjct: 185 QVMTPVDREMAGFAHQAIRDQGVDLRLGTALSEVSYQVQTHVASDAAGEDTAHQHIKGHL 244 Query: 293 -------ENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVG 345 E LE ++L++A+G RP A GL + + G + ++ + P I VG Sbjct: 245 SLTLSNGELLETDLLIMAIGVRPETQ--LARDAGLAIGELGGIKVNAMMQTSDPAIYAVG 302 Query: 346 DVTFG----------PMLAHKAEEEGIAAVEMLKTG-HGHVNYNNIPSVMYSHPEVAWVG 394 D LA A +G A + + + V G Sbjct: 303 DAVEEQDFVTGQACLVPLAGPANRQGRMAADNMFGREERYQGTQGTAICKVFDLAVGATG 362 Query: 395 KTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAHIIGPNAGEM 454 K E+QLK+AGI ++ A+++ + F K+L D I GA +G + + Sbjct: 363 KNEKQLKQAGIAFEKVYVHTASHASYYPGAEVVSF-KLLFDPVKGTIFGAQAVGKDGIDK 421 Query: 455 -IAEAGLALEYGASAEDVARVCHAH-PTLSEAFKEANMAAY 493 I +A G + E + + ++ P A N AA+ Sbjct: 422 RIDVMAVAQRAGMTVEQLQHLELSYAPPYGSAKDVINQAAF 462 >5MJK-A nrPDB Length = 327 Score = 198 bits (503), Expect = 5e-51, Method: Composition-based stats. Identities = 78/329 (23%), Positives = 127/329 (38%), Gaps = 60/329 (18%) Query: 25 KSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCI---PSKALLNNSH 81 K +DVVIIG GPAG AA+ A+ T +E RG GG N I P + Sbjct: 23 KKYDVVIIGSGPAGMTAAMYTARSEMKTLLLE-RGVPGGQMNNTAEIENYPGYETIMGPE 81 Query: 82 LFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSF 141 L +M + G++ N + G Sbjct: 82 LSMKMAEPLEGLGVE---------------------------------NAYGFVTGIEDH 108 Query: 142 EDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGS--EVTPFPGIEIDEEKIVSSTGALS 199 D KI + ED K+II+ATG+ PG E + VS Sbjct: 109 GDYKKI-----------ITEDDEFITKSIIIATGANHRKLEIPGEEEYGARGVSYCAVCD 157 Query: 200 -LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQ 258 + + +IGGG +E +R G VT++ + ++ A E+ + Q+ K++ Sbjct: 158 GAFFRNQEILVIGGGDSAVEEALYLTRFGQSVTIMHRRDKLRA---QEIIQ--QRAFKEE 212 Query: 259 GLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKI 318 ++F + + + DDK + +V ++ KT + + + VG P + + Sbjct: 213 KINFIWDSVPMEI-KGDDKKIQSVVYKNVKTGEVTEKAFGGIFIYVGLDPVAEFV--SDL 269 Query: 319 GLEVDKRGRLVIDDQFNSKFPHIKVVGDV 347 G+ D+ G ++ DD + P I VGDV Sbjct: 270 GI-TDEAGWIITDDHMRTNIPGIFAVGDV 297 >4GCM-A nrPDB Length = 312 Score = 195 bits (496), Expect = 4e-50, Method: Composition-based stats. Identities = 88/358 (24%), Positives = 136/358 (37%), Gaps = 63/358 (17%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLN---VGCIPSKALLNNSHLF 83 D+ IIG GPAG AA+ A++ T +E RG GG N V P ++ L Sbjct: 7 FDIAIIGAGPAGMTAAVYASRANLKTVMIE-RGIPGGQMANTEEVENFPGFEMITGPDLS 65 Query: 84 HQMHTEAQKRG-IDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFE 142 +M A+K G + GDIK S E Sbjct: 66 TKMFEHAKKFGAVYQYGDIK-------------------------------------SVE 88 Query: 143 DETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPF--PGIEIDEEKIVSSTGALS- 199 D+ + +V E L K +I+ATG+E PG + + VS Sbjct: 89 DKGEYKVINFGNKE--------LTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDG 140 Query: 200 LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQG 259 KRL +IGGG +E G+ ++ KVT+V + ++ A + K Sbjct: 141 AFFKNKRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQ-----RILQDRAFKNDK 195 Query: 260 LDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIG 319 +DF S + S D V + + TK +E EA+ + + +G +P A + +G Sbjct: 196 IDFIWSHTLKSINEK-DGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPF--KDLG 252 Query: 320 LEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHK-AEEEGIAAVEMLKTGHGHVN 376 + + G +V D + P I GDV + A +G A + H+N Sbjct: 253 I-TNDVGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLN 309 Score = 28.0 bits (61), Expect = 9.4, Method: Composition-based stats. Identities = 19/115 (16%), Positives = 38/115 (33%), Gaps = 16/115 (13%) Query: 202 EIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQ---------PQI--GASMDGEVAKA 250 EI + IIG G G+ SR K ++E ++ + Sbjct: 4 EIDFDIAIIGAGPAGMTAAVYASRANLKTVMIERGIPGGQMANTEEVENFPGFEMITGPD 63 Query: 251 TQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVG 305 + + F + K +DK +++ + L A+ +++A G Sbjct: 64 LSTKMFEHAKKFGAVYQYGDIKSVEDKGEYKVI-----NFGNKELTAKAVIIATG 113 >2CDU-A nrPDB Length = 452 Score = 191 bits (486), Expect = 6e-49, Method: Composition-based stats. Identities = 74/397 (18%), Positives = 144/397 (36%), Gaps = 38/397 (9%) Query: 120 TGGIELLFKKNKVTYYKGNGSFEDETKI-----RVTPVDGLEGTVKEDHILDVKNIIVAT 174 LF + + + ++ + + E+ +I+ T Sbjct: 54 NNDPRGLFYSSPEELSNLGANVQMRHQVTNVDPETKTIKVKDLITNEEKTEAYDKLIMTT 113 Query: 175 GSEV--TPFPGIEIDEEKIVSSTGALS--LKEIPK--RLTIIGGGIIGLEMGSVYSRLGS 228 GS+ P PGI+ + + +E PK +TIIG G IG E+ YS Sbjct: 114 GSKPTVPPIPGIDSSRVYLCKNYNDAKKLFEEAPKAKTITIIGSGYIGAELAEAYSNQNY 173 Query: 229 KVTVVEFQPQIG-ASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDT 287 V +++ ++ D E K + G++ L +KV + + DD+ + T Sbjct: 174 NVNLIDGHERVLYKYFDKEFTDILAKDYEAHGVNLVLGSKVAAFEEVDDEII-------T 226 Query: 288 KTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGD- 346 KT + +++++ ++ +G RP L K + + G ++ D+ +S I GD Sbjct: 227 KTLDGKEIKSDIAILCIGFRPNTELL---KGKVAMLDNGAIITDEYMHSSNRDIFAAGDS 283 Query: 347 --VTFGP-------MLAHKAEEEGIAA-VEMLKTGHGHVNYNNIPSVMYSHPEVAWVGKT 396 V + P LA A +G + + + + + + G Sbjct: 284 AAVHYNPTNSNAYIPLATNAVRQGRLVGLNLTEDKVKDMGTQSSSGLKLYGRTYVSTGIN 343 Query: 397 EEQLKEAGIDYKIGKFPFAANSRAKTNQDT-EGFVKILIDSKTERILGAHIIG-PNAGEM 454 K + K+ + A N R + T E + ++ D KT ILG + + + Sbjct: 344 TALAKANNL--KVSEVIIADNYRPEFMLSTDEVLMSLVYDPKTRVILGGALSSMHDVSQS 401 Query: 455 IAEAGLALEYGASAEDVARV-CHAHPTLSEAFKEANM 490 + ++ + +D+A V P F N+ Sbjct: 402 ANVLSVCIQNKNTIDDLAMVDMLFQPQFDRPFNYLNI 438 >4ZN0-A nrPDB Length = 311 Score = 188 bits (478), Expect = 4e-48, Method: Composition-based stats. Identities = 70/353 (19%), Positives = 130/353 (36%), Gaps = 66/353 (18%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCL--NVGCIPSKALLNNS 80 + +D++IIGGGPAG A I A + G +T +E+ G + V P ++ Sbjct: 4 MASMYDLIIIGGGPAGLTAGIYAVRYGLDTLILERNEISGQISMADIVENYPGFPSISGL 63 Query: 81 HLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGS 140 L + T AQ+ G +K + + + K++ Sbjct: 64 ELMERFRTHAQEVG------VKTTITEVLSVRSEGTKKI--------------------- 96 Query: 141 FEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSL 200 + L+ K +I+ATG+ G+ ++E I ++ Sbjct: 97 -----------------ITTDSGDLEAKAVIIATGANPKHL-GVPGEKELISKGVSYCAI 138 Query: 201 KEIP----KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLK 256 + P K + ++GGG + S++ KV +V + + A A+ Q + Sbjct: 139 CDGPFFRNKIVAVVGGGNSAVTDALFLSKVAQKVYLVHRRDHLKA------ARVLQDRVD 192 Query: 257 -KQGLDFKLSTKVISA--KRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGL 313 ++ L++ V+ R K V +I++ED + + L + + VG P Sbjct: 193 GTPNIELILNSHVLEIVGTREGIKKVEKIILEDVNSRETRELSTNGVFIYVGIHPNT--- 249 Query: 314 GAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHK-AEEEGIAAV 365 E + +E D+ G + D + I GD P+ A +G A Sbjct: 250 --EFVDVEKDEGGFIKTDRWMETSEKGIYAAGDCRDTPIWQLVTAVRDGAIAA 300 >2Q7V-A nrPDB Length = 325 Score = 178 bits (453), Expect = 4e-45, Method: Composition-based stats. Identities = 78/348 (22%), Positives = 128/348 (36%), Gaps = 61/348 (17%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCL---NVGCIPSK-ALLNNSHL 82 +DVVIIGGGPAG AAI + +T +EK G GG V P + L Sbjct: 9 YDVVIIGGGPAGLTAAIYTGRAQLSTLILEK-GMPGGQIAWSEEVENFPGFPEPIAGMEL 67 Query: 83 FHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFE 142 +MH +A+K G V + Q + DA T NG Sbjct: 68 AQRMHQQAEKFGAKVE------MDEVQGVQHDATSH----------PYPFTVRGYNGE-- 109 Query: 143 DETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTP--FPGIEIDEEKIVSSTGALS- 199 K +I+ATG++ PG + K VS+ Sbjct: 110 ----------------------YRAKAVILATGADPRKLGIPGEDNFWGKGVSTCATCDG 147 Query: 200 LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQG 259 K++ +IGGG +E G ++ +VTV+ + + A+ + + Sbjct: 148 FFYKGKKVVVIGGGDAAVEEGMFLTKFADEVTVIHRRDTLRANKVAQ-----ARAFANPK 202 Query: 260 LDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIG 319 + F T V + D +V + + + KT + L + + + +G P A + K Sbjct: 203 MKFIWDTAVEEIQGAD--SVSGVKLRNLKTGEVSELATDGVFIFIGHVPNTAFV---KDT 257 Query: 320 LEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGP--MLAHKAEEEGIAAV 365 + + G + + D+ + P + GDV+ LA + G A Sbjct: 258 VSLRDDGYVDVRDEIYTNIPMLFAAGDVSDYIYRQLA-TSVGAGTRAA 304 >3IWA-A nrPDB Length = 472 Score = 173 bits (440), Expect = 1e-43, Method: Composition-based stats. Identities = 85/410 (20%), Positives = 148/410 (36%), Gaps = 50/410 (12%) Query: 111 AKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNI 170 +D ++ +E L + + + + + E L + Sbjct: 69 VRDPEFFRINKDVEALVETR------AHAIDRAAHTVEIENL-----RTGERRTLKYDKL 117 Query: 171 IVATGSEVTPFP--GIEIDEEKIVSSTG-------ALSLKEIPKRLTIIGGGIIGLEMGS 221 ++A GS+ P G+++ V++ A+S E+ K I+GGG IGLEM Sbjct: 118 VLALGSKANRPPVEGMDLAGVTPVTNLDEAEFVQHAISAGEVSK-AVIVGGGFIGLEMAV 176 Query: 222 VYSRL-GSKVTVVEFQPQIGASMD-GEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNV 279 + + G TVVE QI +++ + L+K + KV+ + + K Sbjct: 177 SLADMWGIDTTVVELADQIMPGFTSKSLSQMLRHDLEKNDVVVHTGEKVVRLEGENGK-- 234 Query: 280 VEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFP 339 V V+ D +T L+A+++++A G P A GLE+D RG +++D + + P Sbjct: 235 VARVITDKRT-----LDADLVILAAGVSPNTQ--LARDAGLELDPRGAIIVDTRMRTSDP 287 Query: 340 HIKVVGDVTFGP----------MLAHKAEEEGIAAVEMLKTGHGHV-NYNNIPSVMYSHP 388 I GD P L A +G L G +V Sbjct: 288 DIFAGGDCVTIPNLVTGKPGFFPLGSMANRQGRVIGTNLADGDATFPGAVGSWAVKLFEG 347 Query: 389 EVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGF-VKILIDSKTERILGAHI- 446 + G T E G D RA + +++++D T R+LG Sbjct: 348 SASGAGLTVEGALREGYDAV--NVHVEQFDRAHFYPEKTIMTLQLVVDRPTRRVLGIQGF 405 Query: 447 --IGPNAGEMIAEAGLALEYGASAEDVARVCHAH-PTLSEAFKEANMAAY 493 +G I L + ED++ + P + A N+A Sbjct: 406 STLGDALTARINAVATMLASKPTVEDISNAEVVYSPPFASAMDIVNVAGN 455 Score = 33.0 bits (74), Expect = 0.35, Method: Composition-based stats. Identities = 22/136 (16%), Positives = 56/136 (41%), Gaps = 19/136 (13%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLG--SKVTVVEFQPQ-------IGASMDGEVAKA----- 250 K + +IG +G + + RL + VT+++ + I + GEV+ Sbjct: 4 KHVVVIGAVALGPKAACRFKRLDPEAHVTMIDQASRISYGGCGIPYYVSGEVSNIESLQA 63 Query: 251 ----TQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGR 306 + + ++ + V + D+ + +E+ +T ++ L+ + L++A+G Sbjct: 64 TPYNVVRDPEFFRINKDVEALVETRAHAIDRAAHTVEIENLRTGERRTLKYDKLVLALGS 123 Query: 307 RPYIAGL-GAEKIGLE 321 + + G + G+ Sbjct: 124 KANRPPVEGMDLAGVT 139 >5UTH-A nrPDB Length = 319 Score = 173 bits (439), Expect = 2e-43, Method: Composition-based stats. Identities = 66/337 (19%), Positives = 116/337 (34%), Gaps = 63/337 (18%) Query: 22 TINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLN---VGCIPS-KALL 77 T HDV+IIG GPAGY AAI AA+ E + GG + V P + + Sbjct: 11 TSQTVHDVIIIGSGPAGYTAAIYAARAQLKPLVFEGT-QFGGALMTTTEVENYPGFREGI 69 Query: 78 NNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKG 137 L QM +A + G D + V + Sbjct: 70 TGPELMDQMREQALRFGAD------------------------------LRMEDVDAVQL 99 Query: 138 NGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPF--PGIEIDEEKIVSST 195 G + V D + +I+A G+ PG E VS+ Sbjct: 100 EGPV--------------KTVVVGDETHQARAVILAMGAAARHLGVPGEEALTGMGVSTC 145 Query: 196 GALS-LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKF 254 + + ++GGG +E + +R VT++ + + AS ++ Sbjct: 146 ATCDGFFFRDQDIVVVGGGDSAMEEATFLTRFARSVTLIHRRDEFRAS-----KIMLERA 200 Query: 255 LKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLG 314 + + F +T++ + D V + + DT T ++ L+ + VA+G P Sbjct: 201 RANEKITFLTNTEITQIE--GDPKVTGVRLRDTVTGEESKLDVTGVFVAIGHDPRSE--- 255 Query: 315 AEKIGLEVDKRGRLVID-DQFNSKFPHIKVVGDVTFG 350 + +E+D G + + + + GD+ Sbjct: 256 LVRGQVELDDEGYVKVQGRTTYTSLDGVFAAGDLVDH 292 >3AB1-A nrPDB Length = 360 Score = 165 bits (417), Expect = 5e-41, Method: Composition-based stats. Identities = 70/333 (21%), Positives = 125/333 (37%), Gaps = 54/333 (16%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNS------- 80 D+ IIGGGP G AA + + +E +LGG P K + + + Sbjct: 16 DLTIIGGGPTGIFAAFQCGMNNISCRIIESMPQLGGQLA--ALYPEKHIYDVAGFPEVPA 73 Query: 81 -HLFHQMHTEAQKRGIDVNGDIKINVANFQKAK-DDAVKQLTGGIELLFKKNKVTYYKGN 138 L + +A++ N D+ +N + K DD + +++ V G Sbjct: 74 IDLVESLWAQAERY----NPDVVLNETVTKYTKLDDGTFETRTNTGNVYRSRAVLIAAGL 129 Query: 139 GSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGAL 198 G+FE ++ +D L TGS V V S Sbjct: 130 GAFEPRKLPQLGNIDHL------------------TGSSV----------YYAVKSVEDF 161 Query: 199 SLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQ 258 KR+ I+GGG L+ + + VT+V + G+ A ++ Sbjct: 162 K----GKRVVIVGGGDSALDWTVGLIKNAASVTLVHRGHEFQGH--GKTAHEVERARANG 215 Query: 259 GLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKI 318 +D L T+V S + ++ V+ V + + +EA+ LL+ +G + + L + Sbjct: 216 TIDVYLETEVASIEESNG--VLTRVHLRSSDGSKWTVEADRLLILIGFKSNLGPLA--RW 271 Query: 319 GLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGP 351 LE+ + LV+D + + GD+ + P Sbjct: 272 DLELYEN-ALVVDSHMKTSVDGLYAAGDIAYYP 303 >1YQZ-A nrPDB Length = 438 Score = 165 bits (417), Expect = 6e-41, Method: Composition-based stats. Identities = 62/376 (16%), Positives = 135/376 (35%), Gaps = 44/376 (11%) Query: 145 TKIRVTPVDGLEGTVKEDHI-----LDVKNIIVATGSEVTPFPGIEIDEEKIVSS----- 194 ++ + +V +I++ G+ G E D + + Sbjct: 79 HEVIAINDERQTVSVLNRKTNEQFEESYDKLILSPGASANSL-GFESDITFTLRNLEDTD 137 Query: 195 --TGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQ 252 + ++ K + ++G G + LE+ G T++ +I MD ++ + Sbjct: 138 AIDQFIKANQVDK-VLVVGAGYVSLEVLENLYERGLHPTLIHRSDKINKLMDADMNQPIL 196 Query: 253 KFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAG 312 L K+ + ++L+ ++ + N EI + K ++++ VG P Sbjct: 197 DELDKREIPYRLNEEINAINGN------EITFKSGKVEH-----YDMIIEGVGTHPNSKF 245 Query: 313 LGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTF----------GPMLAHKAEEEGI 362 + E +++D++G + ++D+F + P+I +GD+ LA A Sbjct: 246 I--ESSNIKLDRKGFIPVNDKFETNVPNIYAIGDIATSHYRHVDLPASVPLAWGAHRAAS 303 Query: 363 AAVEMLKTGHG--HVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRA 420 E + + V + A VG +LK+ DYK+ + A++ Sbjct: 304 IVAEQIAGNDTIEFKGFLGNNIVKFFDYTFASVGVKPNELKQ--FDYKMVEVTQGAHANY 361 Query: 421 KTNQDTEGFVKILIDSKTERILGAHIIG-PNAGEMIAEAGLALEYGASAEDVARV-CHAH 478 +++ D+ +IL A +G A + I +A+ + +++ Sbjct: 362 YPGNS-PLHLRVYYDTSNRQILRAAAVGKEGADKRIDVLSMAMMNQLTVDELTEFEVAYA 420 Query: 479 PTLSEAFKEANMAAYD 494 P S NM Y Sbjct: 421 PPYSHPKDLINMIGYK 436 >2A87-A nrPDB Length = 335 Score = 161 bits (408), Expect = 6e-40, Method: Composition-based stats. Identities = 69/347 (19%), Positives = 117/347 (33%), Gaps = 63/347 (18%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCL---NVGCIPSKA-LLNNSHLF 83 DV++IG GPAGY AA+ AA+ E GG + +V P + L Sbjct: 16 DVIVIGSGPAGYTAALYAARAQLAPLVFEGTS-FGGALMTTTDVENYPGFRNGITGPELM 74 Query: 84 HQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFED 143 +M +A + G D + V +G + Sbjct: 75 DEMREQALRFGAD------------------------------LRMEDVESVSLHGPLKS 104 Query: 144 ETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPF--PGIEIDEEKIVSSTGALS-L 200 + + +I+A G+ PG + + VSS Sbjct: 105 -------------VVTADGQTHRARAVILAMGAAARYLQVPGEQELLGRGVSSCATCDGF 151 Query: 201 KEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGL 260 + + +IGGG +E + +R VT+V + + AS + + Sbjct: 152 FFRDQDIAVIGGGDSAMEEATFLTRFARSVTLVHRRDEFRAS-----KIMLDRARNNDKI 206 Query: 261 DFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGL 320 F + V++ D V + V DT T + L + VA+G P G + + Sbjct: 207 RFLTNHTVVAVD--GDTTVTGLRVRDTNTGAETTLPVTGVFVAIGHEPRS---GLVREAI 261 Query: 321 EVDKRGRLVID-DQFNSKFPHIKVVGDVTFGPML-AHKAEEEGIAAV 365 +VD G +++ ++ P + GD+ A A G AA Sbjct: 262 DVDPDGYVLVQGRTTSTSLPGVFAAGDLVDRTYRQAVTAAGSGCAAA 308 >3F8P-A nrPDB Length = 323 Score = 160 bits (406), Expect = 1e-39, Method: Composition-based stats. Identities = 72/352 (20%), Positives = 128/352 (36%), Gaps = 57/352 (16%) Query: 20 TLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNN 79 ++ + DV+I+G GPA Y AA+ +A+ T + + GG G + Sbjct: 9 SVKPGEKFDVIIVGLGPAAYGAALYSARYMLKTLVIGE--TPGGQLTEAGIV-------- 58 Query: 80 SHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNG 139 D G I+I ++ K + +++ E+ + V + G Sbjct: 59 ---------------DDYLGLIEIQASDMIKVFNKHIEK----YEVPVLLDIVEKIENRG 99 Query: 140 SFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPF--PGIEIDEEKIVSSTGA 197 D K ++I+ G + PG + + +S Sbjct: 100 -------------DEFVVKTKRKGEFKADSVILGIGVKRRKLGVPGEQEFAGRGISYCSV 146 Query: 198 LSLKEIPKRLT-IIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLK 256 R+ +IGGG LE + S +KV ++ + A + K Sbjct: 147 CDAPLFKNRVVAVIGGGDSALEGAEILSSYSTKVYLIHRRDTFKAQ-----PIYVETVKK 201 Query: 257 KQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAE 316 K ++F L++ V K DK V ++VVE+ KT + + L + + +G P A+ Sbjct: 202 KPNVEFVLNSVVKEIK--GDKVVKQVVVENLKTGEIKELNVNGVFIEIGFDPPTDF--AK 257 Query: 317 KIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTF---GPMLAHKAEEEGIAAV 365 G+E D G + +D+ + P + GD T G A +G A Sbjct: 258 SNGIETDTNGYIKVDEWMRTSVPGVFAAGDCTSAWLGFRQVITAVAQGAVAA 309 >1Q1R-A nrPDB Length = 431 Score = 155 bits (392), Expect = 4e-38, Method: Composition-based stats. Identities = 61/296 (20%), Positives = 111/296 (37%), Gaps = 32/296 (10%) Query: 124 ELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFP- 182 E L+ + Y N T++ D + + + LD +++ATG P P Sbjct: 60 ESLYLRTPDAYAAQNIQLLGGTQVTAINRDRQQVILSDGRALDYDRLVLATGGRPRPLPV 119 Query: 183 -----GIEIDEEKIVSSTGALSLKE---IPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVE 234 G + + + A ++ RL +IGGG IGLE+ + + VT+++ Sbjct: 120 ASGAVGKANNFRYLRTLEDAECIRRQLIADNRLVVIGGGYIGLEVAATAIKANMHVTLLD 179 Query: 235 FQPQIGASMDGEVAKATQKFLKKQ-GLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQE 293 ++ + A + L ++ G+D + T+V + + D+ V V+ + T Sbjct: 180 TAARVLERVTAPPVSAFYEHLHREAGVDIRTGTQVCGFEMSTDQQKVTAVLCEDGT---- 235 Query: 294 NLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTF---- 349 L A++++ +G P A GL+VD +VI++ + P I VGD Sbjct: 236 RLPADLVIAGIGLIPNCE--LASAAGLQVD--NGIVINEHMQTSDPLIMAVGDCARFHSQ 291 Query: 350 ------GPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYSHPEVA--WVGKTE 397 A E+ +L P E+ VG +E Sbjct: 292 LYDRWVRIESVPNALEQARKIAAILCGKVPRDE--AAPWFWSDQYEIGLKMVGLSE 345 Score = 38.4 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 20/128 (15%), Positives = 46/128 (35%), Gaps = 24/128 (18%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQP-QIGASMDGEVAKATQ------------- 252 + I+G G+ G+E+ G + + + ++KA Sbjct: 7 VVIVGTGLAGVEVAFGLRASGWEGNIRLVGDATVIPHHLPPLSKAYLAGKATAESLYLRT 66 Query: 253 -KFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIA 311 Q + T+V + R + ++++ D + L+ + L++A G RP Sbjct: 67 PDAYAAQNIQLLGGTQVTAINR----DRQQVILSDGRA-----LDYDRLVLATGGRPRPL 117 Query: 312 GLGAEKIG 319 + + +G Sbjct: 118 PVASGAVG 125 Score = 33.4 bits (75), Expect = 0.21, Method: Composition-based stats. Identities = 26/147 (17%), Positives = 48/147 (32%), Gaps = 15/147 (10%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHT 88 +V+IGGG G A A + + ++ ++ V P S + +H Sbjct: 152 LVVIGGGYIGLEVAATAIKANMHVTLLDTAARV---LERVTAPP------VSAFYEHLHR 202 Query: 89 EAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIR 148 EA G+D+ ++ + L E + G G + Sbjct: 203 EA---GVDIRTGTQVCGFEMSTDQQKVTAVLC---EDGTRLPADLVIAGIGLIPNCELAS 256 Query: 149 VTPVDGLEGTVKEDHILDVKNIIVATG 175 + G V +H+ +I+A G Sbjct: 257 AAGLQVDNGIVINEHMQTSDPLIMAVG 283 >5XHU-A nrPDB Length = 329 Score = 149 bits (377), Expect = 2e-36, Method: Composition-based stats. Identities = 70/336 (20%), Positives = 121/336 (36%), Gaps = 60/336 (17%) Query: 25 KSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTC---------LNVGCIPSKA 75 + +DV IIGGGP G A T +E KLGG ++G IP Sbjct: 1 EVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGGKVSLFFPEKIIRDIGGIPG-- 58 Query: 76 LLNNSHLFHQMHTEAQKRGIDVNGDIKINVA-NFQKAKDDAVKQLTGGIELLFKKNKVTY 134 + L Q+ +A + DI +N + DD LTG V Sbjct: 59 -IAGKQLIEQLKEQAATF----DPDIVLNQRVTGFERLDDGTIVLTGSEGKKHYTRTVIL 113 Query: 135 YKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSS 194 G G + V D + L V Sbjct: 114 ACGMG------TLEVNEFDSEDAARYAGKNL-----------------------HYGVEK 144 Query: 195 TGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKF 254 A KR+ I GGG ++ + + + VTVV + + G M+ V K Sbjct: 145 LDAFK----GKRVVISGGGDTAVDWANELEPIAASVTVVHRREEFG-GMESSVTK----- 194 Query: 255 LKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLG 314 +K+ + ++ D++ + + V T++ +++++E + L++ G + + + Sbjct: 195 MKQSSVRVLTPYRLEQLN-GDEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPM- 252 Query: 315 AEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFG 350 + GLE+++ GR+ D + P + V GD F Sbjct: 253 -MEWGLEIEE-GRVKADRHMRTNLPGVFVAGDAAFY 286 >5JCN-A nrPDB Length = 451 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 56/281 (19%), Positives = 106/281 (37%), Gaps = 40/281 (14%) Query: 140 SFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALS 199 T+I + T + +I+ATGS V + S L Sbjct: 105 ELILSTEIVKADLASKTLTSAVGATFTYEILIIATGSSVIKLSDF---GTQGADSNNILY 161 Query: 200 LKEIP--------------KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGAS-MD 244 L+E+ + I+GGG IGLE+ + VT+V +P Sbjct: 162 LREVDDADKLVAAIQAKKGGKAVIVGGGYIGLELSAALKINDFDVTMVFPEPWCMPRLFT 221 Query: 245 GEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAV 304 ++A + + +G+ T + + + +V + +++ LEA++++V V Sbjct: 222 ADIAAFYESYYTNKGVKIVKGTVAVGFDADANGDVTAVNLKNGSV-----LEADIVVVGV 276 Query: 305 GRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPML----------- 353 G RP + +++G + D F + P + VGDV PM Sbjct: 277 GGRPLTTLFKGQVA----EEKGGIKTDAFFETSVPGVYAVGDVATFPMKMYNELRRVEHV 332 Query: 354 --AHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYSHPEVAW 392 A K+ E+ + A++ ++G V Y+ +P ++ W Sbjct: 333 DHARKSAEQAVKAIKGKESGESVVEYDYLPYFFSRSFDLGW 373 >5U63-A nrPDB Length = 321 Score = 146 bits (369), Expect = 2e-35, Method: Composition-based stats. Identities = 62/342 (18%), Positives = 111/342 (32%), Gaps = 64/342 (18%) Query: 21 LTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCI---PS-KAL 76 ++ K ++I+G GPAGY AAI AA+ V + GG I P + Sbjct: 4 MSDIKHAKLLILGSGPAGYTAAIYAARANLKPVLVTGLQQ-GGQLTTTDEIENWPGDFEM 62 Query: 77 LNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYK 136 S L +M A+K Sbjct: 63 TTGSGLMQRMLQHAEKF------------------------------------------- 79 Query: 137 GNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPF--PGIEIDEEKIVSS 194 + RV + +I+ATG+ P E + + VS+ Sbjct: 80 -ETEIVFDHINRVDLSSRPFKLFGDVQNFTCDALIIATGASARYIGLPSEENYKGRGVSA 138 Query: 195 TGALS-LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQK 253 K + +IGGG +E + + S V ++ + A + + K Sbjct: 139 CATCDGFFYRNKPVGVIGGGNTAVEEALYLANIASTVHLIHRRDSFRA--EKILIDRLYK 196 Query: 254 FLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGL 313 +++ + + D+ V + + +TKT ++E L+ + L VA+G P Sbjct: 197 KVEEGKIVLHTDRTLDEV-LGDNMGVTGLRLANTKTGEKEELKLDGLFVAIGHSPNTEIF 255 Query: 314 GAEKIGLEVDKRGRLVIDDQF-----NSKFPHIKVVGDVTFG 350 + LE++ G +V+ + + GDV Sbjct: 256 QGQ---LELN-NGYIVVKSGLDGNATATSVEGVFAAGDVMDH 293 >6BWT-A nrPDB Length = 319 Score = 144 bits (363), Expect = 9e-35, Method: Composition-based stats. Identities = 57/342 (16%), Positives = 116/342 (33%), Gaps = 66/342 (19%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCI---PSKA-LLN 78 + H ++I+G GPAGY AAI AA+ + + GG + P + + Sbjct: 4 MANHHKLIILGSGPAGYTAAIYAARANLKPVIITGM-QPGGQLTTTTDVYNWPGEPDGIM 62 Query: 79 NSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGN 138 L ++ +A++ ++ Y N Sbjct: 63 GPELMEKLQKQAERF-----------------------------------DTQIVYDTIN 87 Query: 139 GSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEE---KIVSST 195 V + V E +I+ATG+ G+E +E+ K VS+ Sbjct: 88 A---------VDLQNKPFKLVGEVEQYTCDTLIIATGATAKYL-GLESEEKFMGKGVSAC 137 Query: 196 GALS-LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKF 254 K + ++GGG +E S + VT++ + + + + + + Sbjct: 138 ATCDGFFYKNKDVAVVGGGNTAVEEALFLSNIAKSVTLIHRRDTLRS--EKILIDKLMEK 195 Query: 255 LKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLG 314 + ++ +T + DD V + +++ KTN++ + + +A+G P + Sbjct: 196 AQHGNINIIWNTTLEEV-LGDDMGVNALRIKNIKTNEESQMGVAGVFIAIGHTPNTSIF- 253 Query: 315 AEKIGLEVDKRGRLVID-----DQFNSKFPHIKVVGDVTFGP 351 G + G + + D + + GDV Sbjct: 254 ---AGQLEMENGYIKVKSGLAGDATQTNIKGVFAAGDVADHV 292 >5W4C-A nrPDB Length = 371 Score = 143 bits (361), Expect = 2e-34, Method: Composition-based stats. Identities = 67/335 (20%), Positives = 117/335 (34%), Gaps = 66/335 (19%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKR----GKLGG---TCLNVGCIPSK-ALLNNS 80 VVIIG GP G+ AAI A+ E GG T +V P + + Sbjct: 33 VVIIGSGPGGHTAAIYLARANLEPVLYEGMLANGFAPGGQLTTTTDVENFPGFPEGVTGT 92 Query: 81 HLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGS 140 + + ++++ G + + V Y+ Sbjct: 93 EMMDKFRAQSERFGTKIITETVARVD--------------------LSVRPFKYW----- 127 Query: 141 FEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPF--PGIEIDEEKIVSSTGAL 198 EG +E + II+ATG+ PG E + +S+ Sbjct: 128 --------------TEGEEEEHEFMTADTIILATGASAKRLFLPGEETYWQSGISACAVC 173 Query: 199 SLKEIP----KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKF 254 +P K L +IGGG E + ++ GS V V+ + ++ A +K K Sbjct: 174 D-GAVPIFRQKPLAVIGGGDSAAEEATYLTKYGSHVYVLVRRDELRA------SKIMAKR 226 Query: 255 LKKQ-GLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGL 313 L + +T A + D + + + +++TKT + +L L A+G P + Sbjct: 227 LTSHPKVTVLWNTVATEA-KGDGEVLTSLTIKNTKTGETGDLPVNGLFYAIGHEPATS-- 283 Query: 314 GAEKIGLEVDKRGRLV-IDDQFNSKFPHIKVVGDV 347 K +E+D G + + + + GDV Sbjct: 284 -LVKSQVELDSDGYIKTVPGTSQTSVHGVFAAGDV 317 >1F6M-A nrPDB Length = 320 Score = 140 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 60/341 (17%), Positives = 113/341 (33%), Gaps = 65/341 (19%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKAL----LNN 79 K ++I+G GPAGY AA+ AA+ + K GG + + L Sbjct: 3 TKHSKLLILGSGPAGYTAAVYAARANLQPVLITGMEK-GGQLTTTTEVENWPGDPNDLTG 61 Query: 80 SHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNG 139 L +MH A K ++ D Sbjct: 62 PLLMERMHEHATKFETEIIFD--------------------------------------- 82 Query: 140 SFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPF--PGIEIDEEKIVSSTGA 197 +V + ++ +I+ATG+ P E + + VS++ Sbjct: 83 -----HINKVDLQNRPFRLNGDNGEYTCDALIIATGASARYLGLPSEEAFKGRGVSASAT 137 Query: 198 LS-LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLK 256 +++ +IGGG +E S + S+V ++ + A + + K ++ Sbjct: 138 CDGFFYRNQKVAVIGGGNTAVEEALYLSNIASEVHLIHRRDGFRA--EKILIKRLMDKVE 195 Query: 257 KQGLDFKLSTKVISAKRNDDKNVVEIVVEDT-KTNKQENLEAEVLLVAVGRRPYIAGLGA 315 + + + D V + + DT ++ E+L+ L VA+G P A Sbjct: 196 NGNIILHTNRTLEEVT-GDQMGVTGVRLRDTQNSDNIESLDVAGLFVAIGHSPNTAIFEG 254 Query: 316 EKIGLEVDKRGRLVIDDQF-----NSKFPHIKVVGDVTFGP 351 + LE+ + G + + + P + GDV Sbjct: 255 Q---LEL-ENGYIKVQSGIHGNATQTSIPGVFAAGDVMDHI 291 >5USX-A nrPDB Length = 319 Score = 135 bits (339), Expect = 6e-32, Method: Composition-based stats. Identities = 53/342 (15%), Positives = 106/342 (30%), Gaps = 64/342 (18%) Query: 21 LTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCI---PS-KAL 76 ++ K ++I+G GPAGY AA+ AA+ N + + GG + P Sbjct: 1 MSDMKHSKLLILGSGPAGYTAAVYAARANLNPVLITGMQQ-GGQLTTTTEVENWPGDPEG 59 Query: 77 LNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYK 136 L L +M A++ ++ D Sbjct: 60 LTGPGLMDRMKEHAERFETEIIFD------------------------------------ 83 Query: 137 GNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPF--PGIEIDEEKIVSS 194 V + +I++TG+ E + + VS+ Sbjct: 84 --------HINEVDFSTRPFVLKGDAASYSCDALIISTGASAKYLGLESEEAFKGRGVSA 135 Query: 195 TGALS-LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQK 253 +++ ++GGG +E S + ++V ++ + A + + Sbjct: 136 CATCDGFFYRNQKVAVVGGGNTAVEEALYLSNIAAEVHLIHRRDSFRA--EKILINRLMD 193 Query: 254 FLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGL 313 ++ + +V+ D+ V + ++D KT E L+ +A+G P Sbjct: 194 KVQNGNIVLHTD-RVLDEVLGDEMGVTGVRLKDVKTGGTEELDVMGAFIAIGHSPNTQIF 252 Query: 314 GAEKIGLEVDKRGRLVIDDQF-----NSKFPHIKVVGDVTFG 350 G K G +++ + I GDV Sbjct: 253 Q----GQLDMKDGYILVKSGLEGNATQTSVEGIFAAGDVMDH 290 >4FX9-A nrPDB Length = 453 Score = 134 bits (338), Expect = 7e-32, Method: Composition-based stats. Identities = 87/480 (18%), Positives = 165/480 (34%), Gaps = 74/480 (15%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHT 88 VVIIGGG AG AA + +L K + Sbjct: 9 VVIIGGGAAGMSAASRVKRL-------------------------KPEWDVKVFEATEWV 43 Query: 89 EAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIR 148 GI + + KK + + + I Sbjct: 44 SHAPCGIPYVVEGLSTPDKLMYYPPEV----------FIKKRGIDLH------LNAEVIE 87 Query: 149 VTPVDGLEGTVKEDHILDVKNIIVATGSEV--TPFPGIEIDEEKIVSS-TGALSLKEIPK 205 V + + ++ A G+ G+ + AL+++E + Sbjct: 88 VDTGYVRVRENGGEKSYEWDYLVFANGASPQVPAIEGVNLKGVFTADLPPDALAIREYME 147 Query: 206 R-----LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGAS-MDGEVAKATQKFLKKQG 259 + + IIGGG IG+EM ++ G VT++ ++ D EV ++ LKK Sbjct: 148 KYKVENVVIIGGGYIGIEMAEAFAAQGKNVTMIVRGERVLRRSFDKEVTDILEEKLKKH- 206 Query: 260 LDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIG 319 ++ +L + + + VE VV D +AE++++A G +P I A+++G Sbjct: 207 VNLRLQEITMKIEGEE---RVEKVVTDAG-----EYKAELVILATGIKPNIE--LAKQLG 256 Query: 320 LEVDKRGRLVIDDQFNSKFPHIKVVGDVTF----------GPMLAHKAEEEGIAAVEMLK 369 + + + G + +++ + ++ GDV LA + G A + Sbjct: 257 VRIGETGAIWTNEKMQTSVENVYAAGDVAETRHVITGRRVWVPLAPAGNKMGYVAGSNIA 316 Query: 370 TGHGHV-NYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEG 428 H + E+ G TE + + G D + + E Sbjct: 317 GKELHFPGVLGTAVTKFMDVEIGKTGLTEMEALKEGYDVRTAFIKASTRPHYYPGGR-EI 375 Query: 429 FVKILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAH-PTLSEAFKE 487 ++K ++D++T R+LG ++G + I A L G + +D A+ P + + Sbjct: 376 WLKGVVDNETNRLLGVQVVGSDILPRIDTAAAMLMAGFTTKDAFFTDLAYAPPFAPVWDP 435 >4CBQ-A nrPDB Length = 314 Score = 133 bits (336), Expect = 1e-31, Method: Composition-based stats. Identities = 66/359 (18%), Positives = 125/359 (34%), Gaps = 71/359 (19%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG--------TCLNVGCIPSK 74 ++ HDVVIIG GPA + AAI + E GG T + P Sbjct: 1 MSNIHDVVIIGSGPAAHTAAIYLGRSSLKPVMYEGFMA-GGVAAGGQLTTTTIIENFPGF 59 Query: 75 A-LLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVT 133 ++ + L M T+++K G D V T +L Sbjct: 60 PNGIDGNELMMNMRTQSEKYG-----------TTIITETIDHVDFSTQPFKLF------- 101 Query: 134 YYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGS--EVTPFPGIEIDEEKI 191 +E + K++I+ATG+ + PG + + Sbjct: 102 -------------------------TEEGKEVLTKSVIIATGATAKRMHVPGEDKYWQNG 136 Query: 192 VSSTGALSLKEIP----KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEV 247 VS+ +P K L ++GGG +E ++ GSKV ++ + AS + Sbjct: 137 VSACAICD-GAVPIFRNKVLMVVGGGDAAMEEALHLTKYGSKVIILHRRDAFRASKTMQ- 194 Query: 248 AKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRR 307 ++ L ++ +++++ + + D + + + + + + + L A+G Sbjct: 195 ----ERVLNHPKIEVIWNSELVELEGDGD-LLNGAKIHNLVSGEYKVVPVAGLFYAIGHS 249 Query: 308 PYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPML-AHKAEEEGIAAV 365 P LG + ++ G ++ + + + GDV A A G A Sbjct: 250 PNSKFLGGQ---VKTADDGYILT-EGPKTSVDGVFACGDVCDRVYRQAIVAAGSGCMAA 304 >6BPY-A nrPDB Length = 374 Score = 133 bits (335), Expect = 1e-31, Method: Composition-based stats. Identities = 63/339 (18%), Positives = 118/339 (34%), Gaps = 63/339 (18%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKR----GKLGG---TCLNVGCIPSKA-LL 77 VVIIG GPA + AAI ++ E GG T ++ P + Sbjct: 4 HTKVVIIGSGPAAHTAAIYLSRAELKPVLYEGMLANGTAAGGQLTTTTDIENFPGFPDGI 63 Query: 78 NNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKG 137 + L M ++ + G +V + + + Sbjct: 64 GGAELMENMRKQSIRFGTEVITE--------------------TISRVDLSSKPFKLWTE 103 Query: 138 NGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGS--EVTPFPGIEIDEEKIVSST 195 DG ++ +I+ATG+ PG E + +S+ Sbjct: 104 W-------------NDGP----DKEPACTADAVIIATGANARRLNLPGEETYWQNGISAC 146 Query: 196 GALSLKEIP----KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKAT 251 +P K L +IGGG E ++ GS VTV+ + ++ AS Sbjct: 147 AVCD-GAVPIFRNKPLYVIGGGDSAAEEAMFLAKYGSSVTVLVRRDKLRAS-----KAMA 200 Query: 252 QKFLKKQGLDFKLSTKVISA--KRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPY 309 ++ L + + +T ++ + + + +++T T ++E ++A L AVG P Sbjct: 201 KRLLAHPKVTVRFNTVATEVLGEKKPNGLMTHLRIKNTVTGEEEIVDANGLFYAVGHDPA 260 Query: 310 IAGLGAEKIGLEVDKRGRLVIDD-QFNSKFPHIKVVGDV 347 A K +++D+ G ++ + + GDV Sbjct: 261 TA---LVKGQIDLDEDGYIITKPGTSYTSREGVFACGDV 296 Score = 30.3 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 41/278 (14%), Positives = 80/278 (28%), Gaps = 60/278 (21%) Query: 206 RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQ-----------------PQIGASMDGEVA 248 ++ IIG G SR K + E DG Sbjct: 6 KVVIIGSGPAAHTAAIYLSRAELKPVLYEGMLANGTAAGGQLTTTTDIENFPGFPDGIGG 65 Query: 249 KATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQEN--LEAEVLLVAVGR 306 + ++KQ + F + R D + + + + A+ +++A G Sbjct: 66 AELMENMRKQSIRFGTEVITETISRVDLSSKPFKLWTEWNDGPDKEPACTADAVIIATG- 124 Query: 307 RPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFP-----HIKVVGDVTFGPMLAHKAE--- 358 L G E + + + P + V+G G A +A Sbjct: 125 -ANARRLNLP--GEETYWQNGISACAVCDGAVPIFRNKPLYVIG---GGDSAAEEAMFLA 178 Query: 359 ---------------EEGIAAVEMLKTGHGH-VNYNNIPSVMY---------SHPEVAWV 393 A + L V +N + + + +H + Sbjct: 179 KYGSSVTVLVRRDKLRASKAMAKRLLAHPKVTVRFNTVATEVLGEKKPNGLMTHLRIKNT 238 Query: 394 GKTEEQL-KEAGIDYKIGKFPFAANSRAKTNQDTEGFV 430 EE++ G+ Y +G P A + + + D +G++ Sbjct: 239 VTGEEEIVDANGLFYAVGHDPATALVKGQIDLDEDGYI 276 >3ISH-A nrPDB Length = 311 Score = 132 bits (332), Expect = 3e-31, Method: Composition-based stats. Identities = 62/348 (17%), Positives = 113/348 (32%), Gaps = 59/348 (16%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCL---NVGCIPS-KALLNNSHLF 83 D IIGGGPAG A + A + G A + ++G GG + P K +++ Sbjct: 3 DCAIIGGGPAGLSAGLYATRGGVKNAVLFEKGMPGGQITGSSEIENYPGVKEVVSGLDFM 62 Query: 84 HQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFED 143 + + G +K + Q+ D Sbjct: 63 QPWQEQCFRFG------LKHEMTAVQRVSKK----------------------------D 88 Query: 144 ETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTP--FPGIEIDEEKIVSSTGALS-L 200 + + + + K++I+ATG G K VS+ Sbjct: 89 SHFVILAE---------DGKTFEAKSVIIATGGSPKRTGIKGESEYWGKGVSTCATCDGF 139 Query: 201 KEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGL 260 K + ++GGG +E + + KV ++ + + + Sbjct: 140 FYKNKEVAVLGGGDTAVEEAIYLANICKKVYLIHRRDGFR-----CAPITLEHAKNNDKI 194 Query: 261 DFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGL 320 +F V + D V + +++T TN++ L + VG A L E + Sbjct: 195 EFLTPYVVEEI-KGDASGVSSLSIKNTATNEKRELVVPGFFIFVGYDVNNAVLKQEDNSM 253 Query: 321 --EVDKRGRLVIDDQFNSKFPHIKVVGDV-TFGPMLAHKAEEEGIAAV 365 + D+ G +V+D + + GD+ F P A +G A Sbjct: 254 LCKCDEYGSIVVDFSMKTNVQGLFAAGDIRIFAPKQVVCAASDGATAA 301 >4YKF-A nrPDB Length = 521 Score = 131 bits (329), Expect = 8e-31, Method: Composition-based stats. Identities = 52/253 (20%), Positives = 101/253 (39%), Gaps = 14/253 (5%) Query: 102 KINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKE 161 +++ N+ ++L G +++ + V + + + Sbjct: 252 TVDIENYISVPKTEGQKLAGALKVHVDEYDVDVIDSQSA--SKLIPAAVEGGLHQIETAS 309 Query: 162 DHILDVKNIIVATGS--EVTPFPGIEIDEEKIVSSTGALSLK-EIPKRLTIIGGGIIGLE 218 +L ++IIVATG+ PG + K V+ KR+ +IGGG G+E Sbjct: 310 GAVLKARSIIVATGAKWRNMNVPGEDQYRTKGVTYCPHCDGPLFKGKRVAVIGGGNSGVE 369 Query: 219 MGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKN 278 + + VT++EF P++ A +V + + LK +D L+ + + D Sbjct: 370 AAIDLAGIVEHVTLLEFAPEMKAD---QVLQDKLRSLKN--VDIILNAQTTEV-KGDGSK 423 Query: 279 VVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKF 338 VV + D + N+E + V +G P L + +E ++ G ++ID + + Sbjct: 424 VVGLEYRDRVSGDIHNIELAGIFVQIGLLPNTNWL---EGAVERNRMGEIIIDAKCETNV 480 Query: 339 PHIKVVGDVTFGP 351 + GD T P Sbjct: 481 KGVFAAGDCTTVP 493 >3D8X-A nrPDB Length = 326 Score = 129 bits (325), Expect = 2e-30, Method: Composition-based stats. Identities = 66/334 (19%), Positives = 117/334 (35%), Gaps = 65/334 (19%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGK----LGGTCLNVGCI---PSKA-LLNNS 80 V IIG GPA + AAI A+ E GG I P L S Sbjct: 13 VTIIGSGPAAHTAAIYLARAEIKPILYEGMMANGIAAGGQLTTTTEIENFPGFPDGLTGS 72 Query: 81 HLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGS 140 L +M ++ K G ++ + V + Sbjct: 73 ELMDRMREQSTKFGTEIITETVSKVD--------------------LSSKPFKLW----- 107 Query: 141 FEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGS--EVTPFPGIEIDEEKIVSSTGAL 198 ++ + II+ATG+ + PG E +K +S+ Sbjct: 108 ---------------TEFNEDAEPVTTDAIILATGASAKRMHLPGEETYWQKGISACAVC 152 Query: 199 SLKEIP----KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKF 254 +P K L +IGGG E ++ GSKV ++ + + AS ++ Sbjct: 153 D-GAVPIFRNKPLAVIGGGDSACEEAQFLTKYGSKVFMLVRKDHLRAS-----TIMQKRA 206 Query: 255 LKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLG 314 K + ++ +T + A + D K + + +++TK N++ +L L A+G P + Sbjct: 207 EKNEKIEILYNTVALEA-KGDGKLLNALRIKNTKKNEETDLPVSGLFYAIGHTPATKIVA 265 Query: 315 AEKIGLEVDKRGRLVIDDQFN-SKFPHIKVVGDV 347 + ++ D+ G + + + P GDV Sbjct: 266 GQ---VDTDEAGYIKTVPGSSLTSVPGFFAAGDV 296 >3LZX-A nrPDB Length = 332 Score = 127 bits (320), Expect = 1e-29, Method: Composition-based stats. Identities = 58/336 (17%), Positives = 117/336 (34%), Gaps = 60/336 (17%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCL---------NVGCIPSK 74 K +D+ IIGGGP G A + +E +LGG +V P Sbjct: 5 TKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGGQLSALYPEKYIYDVAGFPK- 63 Query: 75 ALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTY 134 + L + + + K D ++ V + +K D K +T E V Sbjct: 64 --IRAQELINNLKEQMAKF--DQTICLEQAVESVEKQADGVFKLVTN--EETHYSKTVII 117 Query: 135 YKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSS 194 GNG+F+ K+ + + EG V Sbjct: 118 TAGNGAFK-PRKLELENAEQYEGKNL----------------------------HYFVDD 148 Query: 195 TGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKF 254 + +R+ I+GGG ++ + + +V+++ + + A + + + Sbjct: 149 LQKFA----GRRVAILGGGDSAVDWALMLEPIAKEVSIIHRRDKFRAH------EHSVEN 198 Query: 255 LKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLG 314 L ++ D + ++V+E+ K +++E LE + L+V G + + Sbjct: 199 LHASKVNVLTPFVPAELIGED--KIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPI- 255 Query: 315 AEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFG 350 + GL+++K +V+ + GD+ Sbjct: 256 -KNWGLDIEKN-SIVVKSTMETNIEGFFAAGDICTY 289 >3LXD-A nrPDB Length = 415 Score = 126 bits (318), Expect = 1e-29, Method: Composition-based stats. Identities = 53/280 (18%), Positives = 103/280 (36%), Gaps = 35/280 (12%) Query: 140 SFEDETKIRVTPVDGLEGTVK--EDHILDVKNIIVATGSEVTPFP--GIEIDEEKIVSST 195 + E + V +D TVK + ++ +I ATG + G ++ V + Sbjct: 79 AVEMKLGAEVVSLDPAAHTVKLGDGSAIEYGKLIWATGGDPRRLSCVGADLAGVHAVRTK 138 Query: 196 GALS-----LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGE-VAK 249 L K +IGGG IGLE +V ++ G VT++E P++ A + GE +++ Sbjct: 139 EDADRLMAELDAGAKNAVVIGGGYIGLEAAAVLTKFGVNVTLLEALPRVLARVAGEALSE 198 Query: 250 ATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPY 309 Q + G+D + + D V + ++D + A++++V +G P Sbjct: 199 FYQAEHRAHGVDLRTGA-AMDCIEGDGTKVTGVRMQDGSV-----IPADIVIVGIGIVPC 252 Query: 310 IAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGP-----------MLAHKAE 358 + L + + +D+ + + +GD A Sbjct: 253 VGALISAGAS----GGNGVDVDEFCRTSLTDVYAIGDCAAHANDFADGAVIRLESVQNAN 308 Query: 359 EEGIAAVEMLKTGHGHVNYNNIPSVMY--SHPEVAWVGKT 396 + AA + + V Y P ++ VG + Sbjct: 309 DMATAAAKDICG--APVPYKATPWFWSNQYDLKLQTVGLS 346 Score = 31.1 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 19/94 (20%), Positives = 32/94 (34%), Gaps = 12/94 (12%) Query: 30 VIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTE 89 V+IGGG G AA + G N +E ++ A + L E Sbjct: 156 VVIGGGYIGLEAAAVLTKFGVNVTLLEALPRV------------LARVAGEALSEFYQAE 203 Query: 90 AQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGI 123 + G+D+ ++ K V+ G + Sbjct: 204 HRAHGVDLRTGAAMDCIEGDGTKVTGVRMQDGSV 237 Score = 28.4 bits (62), Expect = 8.0, Method: Composition-based stats. Identities = 15/102 (14%), Positives = 36/102 (35%), Gaps = 5/102 (4%) Query: 224 SRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFK----LSTKVISAKRNDDKNV 279 + +V V+ +P+I + + + + + K + K + Sbjct: 31 NGFEGRVLVIGREPEIPYERPPLSKEYLAREKTFERICIRPAQFWEDKAVEMKLGAEVVS 90 Query: 280 VEIVVEDTKTNKQENLEAEVLLVAVGRRP-YIAGLGAEKIGL 320 ++ K +E L+ A G P ++ +GA+ G+ Sbjct: 91 LDPAAHTVKLGDGSAIEYGKLIWATGGDPRRLSCVGADLAGV 132 >1FL2-A nrPDB Length = 310 Score = 126 bits (318), Expect = 2e-29, Method: Composition-based stats. Identities = 52/253 (20%), Positives = 101/253 (39%), Gaps = 14/253 (5%) Query: 102 KINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKE 161 +++ N+ ++L G +++ + V + + + Sbjct: 41 TVDIENYISVPKTEGQKLAGALKVHVDEYDVDVIDSQSA--SKLIPAAVEGGLHQIETAS 98 Query: 162 DHILDVKNIIVATGS--EVTPFPGIEIDEEKIVSSTGALSLK-EIPKRLTIIGGGIIGLE 218 +L ++IIVATG+ PG + K V+ KR+ +IGGG G+E Sbjct: 99 GAVLKARSIIVATGAKWRNMNVPGEDQYRTKGVTYCPHCDGPLFKGKRVAVIGGGNSGVE 158 Query: 219 MGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKN 278 + + VT++EF P++ A +V + + LK +D L+ + + D Sbjct: 159 AAIDLAGIVEHVTLLEFAPEMKAD---QVLQDKLRSLKN--VDIILNAQTTEV-KGDGSK 212 Query: 279 VVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKF 338 VV + D + N+E + V +G P L + +E ++ G ++ID + + Sbjct: 213 VVGLEYRDRVSGDIHNIELAGIFVQIGLLPNTNWL---EGAVERNRMGEIIIDAKCETNV 269 Query: 339 PHIKVVGDVTFGP 351 + GD T P Sbjct: 270 KGVFAAGDCTTVP 282 >2ZBW-A nrPDB Length = 335 Score = 125 bits (313), Expect = 7e-29, Method: Composition-based stats. Identities = 66/332 (19%), Positives = 113/332 (34%), Gaps = 50/332 (15%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQ 85 DV+I+G GP G A G + V+ + GG P K Sbjct: 5 HTDVLIVGAGPTGLFAGFYVGMRGLSFRFVDPLPEPGGQL--TALYPEK----------- 51 Query: 86 MHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDET 145 DV G K+ + K + V L + + Sbjct: 52 -------YIYDVAGFPKVYAKDLVKGLVEQVAPFNPVYSLGERAETLE------------ 92 Query: 146 KIRVTPVDGLEGTVKEDHILDVKNIIVATGS---EVTPF--PGIEIDEEKIVSSTGALSL 200 D + T + + K +I+A G E PG E + V Sbjct: 93 ----REGDLFKVTTSQGNAYTAKAVIIAAGVGAFEPRRIGAPGEREFEGRGVYYAVKSKA 148 Query: 201 KEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGL 260 + KR+ I+GGG ++ ++T++ +PQ A K K ++ L Sbjct: 149 EFQGKRVLIVGGGDSAVDWALNLLDTARRITLIHRRPQFRAHEAS--VKELMKAHEEGRL 206 Query: 261 DFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLG-AEKIG 319 + ++ + D+ V VV +T ++ LE + +L+ G YI LG G Sbjct: 207 EVLTPYELRRVE--GDERVRWAVVFHNQTQEELALEVDAVLILAG---YITKLGPLANWG 261 Query: 320 LEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGP 351 L ++K ++ +D + P + GD+ P Sbjct: 262 LALEKN-KIKVDTTMATSIPGVYACGDIVTYP 292 >4EMJ-A nrPDB Length = 410 Score = 124 bits (312), Expect = 8e-29, Method: Composition-based stats. Identities = 53/229 (23%), Positives = 99/229 (43%), Gaps = 20/229 (8%) Query: 135 YKGNGSFEDETKIRVTPVDGLEGTVKEDH--ILDVKNIIVATGSEVT--PFPGIEIDEEK 190 + G + T VT +D T+ D L I++ATGS PG ++ Sbjct: 66 WYGEARIDMLTGPEVTALDVQTRTISLDDGTTLSADAIVIATGSRARTMALPGSQLPGVV 125 Query: 191 IVSSTGALSL----KEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIG-ASMDG 245 + + G + + RL I+GGG+IG E+ + +LG VT++E ++ + Sbjct: 126 TLRTYGDVQVLRDSWTSATRLLIVGGGLIGCEVATTARKLGLSVTILEAGDELLVRVLGR 185 Query: 246 EVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVG 305 + + L + G+ +L T V+ + + + +++ D ++ A+ L+ VG Sbjct: 186 RIGAWLRGLLTELGVQVELGTGVVGF--SGEGQLEQVMASDGRS-----FVADSALICVG 238 Query: 306 RRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLA 354 P A A + GL D+ +++D + + VGDV P+ A Sbjct: 239 AEP--ADQLARQAGLACDR--GVIVDHCGATLAKGVFAVGDVASWPLRA 283 Score = 29.5 bits (65), Expect = 3.2, Method: Composition-based stats. Identities = 25/164 (15%), Positives = 50/164 (30%), Gaps = 7/164 (4%) Query: 206 RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLS 265 + IIG G+ G G + + + D + Sbjct: 4 HVAIIGNGVGGFTTAQALRAEGFEGRISLIGDEPHLPYDRPSLSKAVLDGSLERPPILAE 63 Query: 266 TKVISAKRNDDKNVVEIVVEDTKT-----NKQENLEAEVLLVAVGRRPYIAGLGAEKIG- 319 R D E+ D +T + L A+ +++A G R L ++ Sbjct: 64 ADWYGEARIDMLTGPEVTALDVQTRTISLDDGTTLSADAIVIATGSRARTMALPGSQLPG 123 Query: 320 -LEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGI 362 + + G + + + + +VG G +A A + G+ Sbjct: 124 VVTLRTYGDVQVLRDSWTSATRLLIVGGGLIGCEVATTARKLGL 167 Score = 29.5 bits (65), Expect = 3.3, Method: Composition-based stats. Identities = 11/33 (33%), Positives = 18/33 (54%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKL 61 ++I+GGG G A A +LG + +E +L Sbjct: 146 LLIVGGGLIGCEVATTARKLGLSVTILEAGDEL 178 >6GAS-A nrPDB Length = 331 Score = 124 bits (311), Expect = 1e-28, Method: Composition-based stats. Identities = 57/338 (16%), Positives = 125/338 (36%), Gaps = 52/338 (15%) Query: 18 VRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALL 77 ++ K +D+ IIGGGP G A + +E +LGG P K + Sbjct: 1 MKVAENQKVYDITIIGGGPTGLFTAFYGGMRQASVKIIESLPQLGGQL--SALYPEKYIY 58 Query: 78 NNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKG 137 + + F ++ + ++ N+ K D V L ++ L K+ Sbjct: 59 DVAG-FPKVRAQ----------ELVDNLKEQMKKFDPTVC-LEEAVDTLEKQ-------- 98 Query: 138 NGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGA 197 DG+ V K++I+ G+ +E++ Sbjct: 99 --------------ADGIFKLVTNKQTHYSKSVIITAGNGAFQPRRLELEGTAKYEKKNL 144 Query: 198 LSL-----KEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQ 252 K KR+ + GGG ++ + + KVT+V + + A + + Sbjct: 145 HYFVDDMNKFAGKRVVVFGGGDSAVDWTMMLEPIAEKVTIVHRRDKFRAHE-----HSVE 199 Query: 253 KFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAG 312 + + ++ST + + D + ++V++ KT ++ ++ + ++V G + Sbjct: 200 NLMNSRA---EVSTPYVPVELIGDDKIEQVVLQHVKTEEKVIIDVDDVIVNYGFVSSLGP 256 Query: 313 LGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFG 350 + + GL++ K ++++ + + P I GD+ Sbjct: 257 I--KNWGLDIQKN-SILVNSKMETNIPGIYAAGDICTY 291 >5JFC-L nrPDB Length = 474 Score = 121 bits (305), Expect = 6e-28, Method: Composition-based stats. Identities = 67/372 (18%), Positives = 128/372 (34%), Gaps = 94/372 (25%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHT 88 V IIG GPAG A A++G+ E + GG + IP L + + Sbjct: 157 VAIIGAGPAGLTCAADLAKMGYEVTIYEALHQPGGVLIY--GIPEFRL--PKEIVKKELE 212 Query: 89 EAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIR 148 ++ G+ + Sbjct: 213 NLRRLGVKIE-------------------------------------------------- 222 Query: 149 VTPVDGLEGTVKEDHILDVKNIIVATGSEVT---PFPGIEIDEEK----IVSSTGALSLK 201 T V + E+ + I + TG+ P+PG+ ++ ++ + Sbjct: 223 -TNVLVGKTITFEELREEYDAIFIGTGAGTPRIYPWPGVNLNGIYSANEFLTRINLMKAY 281 Query: 202 EIP---------KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAK--A 250 + P KR+ +IGGG ++ RLG++V ++ + + E+ Sbjct: 282 KFPEYDTPIKVGKRVAVIGGGNTAMDAARSALRLGAEVWILYRRTR------KEMTAREE 335 Query: 251 TQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTK--------------TNKQENLE 296 K +++G+ F +++ N+ I +E K T + +E Sbjct: 336 EIKHAEEEGVKFMFLVTPKRFIGDENGNLKAIELEKMKLGEPDESGRRRPIPTGETFIME 395 Query: 297 AEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHK 356 + ++A+G+ P L GL+VD+ GR+V+D+ + P + GD G Sbjct: 396 FDTAIIAIGQTPNKTFLET-VPGLKVDEWGRIVVDENLMTSIPGVFAGGDAIRGEATVIL 454 Query: 357 AEEEGIAAVEML 368 A +G A + + Sbjct: 455 AMGDGRKAAKAI 466 Score = 50.3 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 25/135 (18%), Positives = 51/135 (37%), Gaps = 29/135 (21%) Query: 184 IEIDEEKIVSSTGALS----LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQI 239 + E + L +K K++ IIG G GL + +++G +VT+ E Q Sbjct: 130 ADYAREHGIDDELLLEEIKGIKRNGKKVAIIGAGPAGLTCAADLAKMGYEVTIYEALHQP 189 Query: 240 GA---------SMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTN 290 G + E+ K + L++ G+ + + ++V T T Sbjct: 190 GGVLIYGIPEFRLPKEIVKKELENLRRLGVKIETN----------------VLVGKTITF 233 Query: 291 KQENLEAEVLLVAVG 305 ++ E + + + G Sbjct: 234 EELREEYDAIFIGTG 248 >5M5J-A nrPDB Length = 325 Score = 121 bits (303), Expect = 8e-28, Method: Composition-based stats. Identities = 62/339 (18%), Positives = 117/339 (34%), Gaps = 60/339 (17%) Query: 36 PAGYVAAIKAAQLGFNTAC---VEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQK 92 PAG A I A++ T +E ++ T +V PS + L + +A+ Sbjct: 27 PAGLTAGIYASRANLKTCVFVGIEHTSQMFTT-TDVENFPSHTAIKGPALMEAIQNQAEH 85 Query: 93 RGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPV 152 G ++ + ++ G Sbjct: 86 CGAELLYEDVHSID--------------------VSSRPFKIVHGY-------------- 111 Query: 153 DGLEGTVKEDHILDVKNIIVATGSEVTPF--PGIEIDEEKIVSSTGALSLK-EIPKRLTI 209 E+ +I+ATG+ G + +K VS+ K + + Sbjct: 112 --------ENETTLADALIIATGATARRLDCKGEKEYWQKGVSACAVCDSAMATGKEVVV 163 Query: 210 IGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVI 269 +GGG + E + +++ +KV +V + + AS A +K + ++ ++ + + Sbjct: 164 VGGGDVACEEATYLTKIATKVYMVLRRDKFRAS-----AAMVKKVMNEKLIEIIYDSAID 218 Query: 270 SAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLV 329 + D K V + +++ K K L A L AVG P + L +K LE D+ G ++ Sbjct: 219 EI-KGDGKCVTSVSIKNLKDGKTRTLNAGALYWAVGHDPQTSFL--KKGQLEQDEAGYIL 275 Query: 330 IDDQ--FNSKFPHIKVVGDVTFGPML-AHKAEEEGIAAV 365 + D + + GD A A G A Sbjct: 276 LKDHPTQRTSVDGVFAAGDCCDHLYRQAVVAAGSGSKAA 314 >4YRY-B nrPDB Length = 468 Score = 120 bits (301), Expect = 2e-27, Method: Composition-based stats. Identities = 71/384 (18%), Positives = 129/384 (33%), Gaps = 93/384 (24%) Query: 18 VRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALL 77 V+ L +K V ++G GPAG AA A++G++ E K GG + IP L Sbjct: 132 VKPLAGSKKEKVAVVGSGPAGLTAAADLAKMGYHVDIFEAFHKPGGVLVY--GIPEFRLP 189 Query: 78 NNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKG 137 + + +++L + F N V Sbjct: 190 ----------------------------KRIVEREVSYIRKL----GVNFHLNTVV---- 213 Query: 138 NGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGA 197 ++V + + + + TG+ F GI V S Sbjct: 214 ------GKTVKVKELLS-----------EYDAVFIGTGAGTPKFMGIPGTNLNGVYSANE 256 Query: 198 L----------------SLKEIPKRLTIIGGGIIGLEMGSVYSRLGSK-VTVVEFQPQIG 240 + + K++ +IG G ++ RLG++ V +V + + Sbjct: 257 FLTRVNLMKAYLFPEYDTPIRVGKKVAVIGAGNTAMDAARSALRLGAEKVYIVYRRTE-- 314 Query: 241 ASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVV-------EIVVEDTKT---- 289 + L++ G++F T I + + NV E+ D Sbjct: 315 -REMPARREEYHHALEE-GIEFLWLTLPIRYIGDANGNVEAMECVRMELKEADGSGRPRP 372 Query: 290 ----NKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVID-DQFNSKFPHIKVV 344 LE ++++ A+G+ P L +E GLE+++RG + D D + + Sbjct: 373 VPIEGSNFVLEVDMVIEAIGQGPN-RVLLSEFPGLELNERGYIKADEDTGATSVKGVFAG 431 Query: 345 GDVTFGPMLAHKAEEEGIAAVEML 368 GD+ G KA G A + + Sbjct: 432 GDIVTGAATVIKAMGAGKKAAQFI 455 Score = 34.5 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 41/242 (16%), Positives = 78/242 (32%), Gaps = 40/242 (16%) Query: 17 TVRTLTINKSHDVVIIGGGPA-------------GYVAAIK--AAQLGFNTACVEKRGKL 61 TV+ + +D V IG G G +A + + Sbjct: 216 TVKVKELLSEYDAVFIGTGAGTPKFMGIPGTNLNGVYSANEFLTRVNLMKAYLFPEYDTP 275 Query: 62 GGTCLNVGCIPSK-ALLNNSHLFHQMHTEAQKRGID-VNGDIKINVANFQKAKDDAVKQL 119 + VG K A++ + A + G + V + +++ L Sbjct: 276 ----IRVG---KKVAVIGAGNTAMDAARSALRLGAEKVYIVYRRTEREMPARREEYHHAL 328 Query: 120 TGGIELLFKKNKVTYY---KGNGSFEDETKIRVTPVDGLEGTVK-----EDHILDVKNII 171 GIE L+ + Y GN + ++ + DG + +L+V +I Sbjct: 329 EEGIEFLWLTLPIRYIGDANGNVEAMECVRMELKEADGSGRPRPVPIEGSNFVLEVDMVI 388 Query: 172 VATGSEV-----TPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRL 226 A G + FPG+E++E + + + + GG I +V + Sbjct: 389 EAIGQGPNRVLLSEFPGLELNERGYIKADEDTGATSVKG---VFAGGDIVTGAATVIKAM 445 Query: 227 GS 228 G+ Sbjct: 446 GA 447 >2YVG-A nrPDB Length = 408 Score = 119 bits (298), Expect = 4e-27, Method: Composition-based stats. Identities = 52/243 (21%), Positives = 97/243 (39%), Gaps = 33/243 (13%) Query: 156 EGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEI-----PK-RLTI 209 + + L +++ATG+ P ++ + + + I P+ RL I Sbjct: 91 TVALSDGRTLPYGTLVLATGAAPRALPTLQGATMPVHTLRTLEDARRIQAGLRPQSRLLI 150 Query: 210 IGGGIIGLEMGSVYSRLGSKVTVVEFQPQIG-ASMDGEVAKATQKFLKKQGLDFKLSTKV 268 +GGG+IGLE+ + G V++VE QP++ + +A ++ QG+D + Sbjct: 151 VGGGVIGLELAATARTAGVHVSLVETQPRLMSRAAPATLADFVARYHAAQGVDLR----- 205 Query: 269 ISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRL 328 +R+ +V +V+ D T + A++++V +G A GL D + Sbjct: 206 --FERSVTGSVDGVVLLDDGT----RIAADMVVVGIGVLAN--DALARAAGLACDD--GI 255 Query: 329 VIDDQFNSKFPHIKVVGDVTF----------GPMLAHKAEEEGIAAVEMLKTGHGHVNYN 378 +D + P + +GDVT A+ +GIA L Y Sbjct: 256 FVDAYGRTTCPDVYALGDVTRQRNPLSGRFERIETWSNAQNQGIAVARHLVD-PTAPGYA 314 Query: 379 NIP 381 +P Sbjct: 315 ELP 317 Score = 29.5 bits (65), Expect = 3.2, Method: Composition-based stats. Identities = 11/33 (33%), Positives = 18/33 (54%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKL 61 ++I+GGG G A A G + + VE + +L Sbjct: 148 LLIVGGGVIGLELAATARTAGVHVSLVETQPRL 180 Score = 28.4 bits (62), Expect = 8.4, Method: Composition-based stats. Identities = 13/110 (11%), Positives = 34/110 (30%), Gaps = 12/110 (10%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMD-GEVAKATQKFLKKQGLDFKLS 265 + ++G G+ + + + G + + + D ++K + + Sbjct: 10 VVVLGAGLASVSFVAELRQAGYQGLITVVGDEAERPYDRPPLSKDFMAHGDAEKIRLDCK 69 Query: 266 TKVI------SAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPY 309 ++ D + + D +T L L++A G P Sbjct: 70 RAPEVEWLLGVTAQSFDPQAHTVALSDGRT-----LPYGTLVLATGAAPR 114 >1VDC-A nrPDB Length = 333 Score = 118 bits (296), Expect = 5e-27, Method: Composition-based stats. Identities = 66/357 (18%), Positives = 118/357 (33%), Gaps = 72/357 (20%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGK----LGG---TCLNVGCIPSK-ALLNNS 80 + I+G GPA + AAI AA+ E GG T +V P + Sbjct: 11 LCIVGSGPAAHTAAIYAARAELKPLLFEGWMANDIAPGGQLTTTTDVENFPGFPEGILGV 70 Query: 81 HLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGS 140 L + ++++ G + Sbjct: 71 ELTDKFRKQSERFGT--------------------------------------------T 86 Query: 141 FEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDE------EKIVSS 194 ET +V + + +I+A G+ + E + +S+ Sbjct: 87 IFTETVTKVDFSSKPFKLFTDSKAILADAVILAIGAVAKRLSFVGSGEVLGGFWNRGISA 146 Query: 195 TGALSLKEIP---KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKAT 251 K L +IGGG +E + ++ GSKV ++ + AS + Sbjct: 147 CAVCDGAAPIFRNKPLAVIGGGDSAMEEANFLTKYGSKVYIIHRRDAFRASKIMQ----- 201 Query: 252 QKFLKKQGLDFKLSTKVISAKRNDDKNVV-EIVVEDTKTNKQENLEAEVLLVAVGRRPYI 310 Q+ L +D ++ V+ A + +++V+ + V++ T +L+ L A+G P Sbjct: 202 QRALSNPKIDVIWNSSVVEAYGDGERDVLGGLKVKNVVTGDVSDLKVSGLFFAIGHEPAT 261 Query: 311 AGLGAEKIGLEVDKRGRLVIDD-QFNSKFPHIKVVGDVTFGPML-AHKAEEEGIAAV 365 L G+E+D G +V + P + GDV A A G A Sbjct: 262 KFL---DGGVELDSDGYVVTKPGTTQTSVPGVFAAGDVQDKKYRQAITAAGTGCMAA 315 >6GAR-A nrPDB Length = 349 Score = 118 bits (296), Expect = 6e-27, Method: Composition-based stats. Identities = 61/338 (18%), Positives = 118/338 (34%), Gaps = 58/338 (17%) Query: 21 LTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNS 80 + + DV +IGGGPAG +A + T +E LGG ++V P K + + Sbjct: 1 MNREELFDVTVIGGGPAGLYSAFYSGLREMRTKIIEFHPHLGGK-IHV--YPEKMIWDVG 57 Query: 81 HLF----HQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYK 136 L ++ + ++G+ ++ ++ KV Sbjct: 58 GLLPVTGDKLIEQLVQQGLTFKPEVVLD-------------------------TKVESI- 91 Query: 137 GNGSFEDETKIRVTPVDGL-EGTVKEDHILDVKNIIVATGSEVTPFP--GIEIDEEKIVS 193 + DG K +IVATGS + IE E VS Sbjct: 92 ------------IRNQDGTFTLKTSTGEEHFSKTVIVATGSGILKPQKLSIEGAERFEVS 139 Query: 194 STGAL--SLKEIPKRLTII-GGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKA 250 + SLK + II GGG ++ + + KV V + + + + +V Sbjct: 140 NLNYTVKSLKRFKGKTVIISGGGNSAVDWANELEPIAKKVYVTYRKEE-LSGHEAQV--- 195 Query: 251 TQKFLKKQGLDFKLSTKVISAKRNDDKNVVE-IVVEDTKTNKQENLEAEVLLVAVGRRPY 309 K L + +T + D+ +E + + + +T + +L + +++ G Sbjct: 196 --KQLMNSSAECFFNTSITKLIAGDNHEAIEYVELTNHETGEVSHLPIDEVIINHGYERD 253 Query: 310 IAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDV 347 I L ++ + + + + S + GD+ Sbjct: 254 ITLLENSELDVAIIDNYYIAGNANSESSVDGLYAAGDI 291 >3FG2-P nrPDB Length = 404 Score = 117 bits (294), Expect = 1e-26, Method: Composition-based stats. Identities = 44/243 (18%), Positives = 89/243 (36%), Gaps = 27/243 (11%) Query: 151 PVDGLEGTVKEDHILDVKNIIVATGSE--VTPFPGIEIDEEKIVSSTGALSL--KEIP-- 204 +G + + ++ ++++ATG+ + P + + + + + + +P Sbjct: 83 DREGRKLLLASGTAIEYGHLVLATGARNRMLDVPNASLPDVLYLRTLDESEVLRQRMPDK 142 Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGAS-MDGEVAKATQKFLKKQGLDFK 263 K + +IG G IGLE + G +V VVE P++ A + E++ G+ Sbjct: 143 KHVVVIGAGFIGLEFAATARAKGLEVDVVELAPRVMARVVTPEISSYFHDRHSGAGIRMH 202 Query: 264 LSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVD 323 + D V +V+ D T L ++++V VG P + A + Sbjct: 203 YGVRATEIAAEGD-RVTGVVLSDGNT-----LPCDLVVVGVGVIPNVEIAAAAGLPTAA- 255 Query: 324 KRGRLVIDDQFNSKFPHIKVVGDV----------TFGPMLAHKAEEEGIAAVEMLKTGHG 373 +++D Q + PHI +GD T A ++ L Sbjct: 256 ---GIIVDQQLLTSDPHISAIGDCALFESVRFGETMRVESVQNATDQARCVAARLTGDAK 312 Query: 374 HVN 376 + Sbjct: 313 PYD 315 Score = 31.1 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 15/42 (35%), Positives = 18/42 (42%), Gaps = 1/42 (2%) Query: 15 SSTVRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVE 56 S +R +K H VV+IG G G A A G VE Sbjct: 132 SEVLRQRMPDKKH-VVVIGAGFIGLEFAATARAKGLEVDVVE 172 >5VJ7-A nrPDB Length = 476 Score = 115 bits (287), Expect = 6e-26, Method: Composition-based stats. Identities = 68/371 (18%), Positives = 123/371 (33%), Gaps = 91/371 (24%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHT 88 V IIG GPAG A A++G+ E + GG IP L + + Sbjct: 157 VAIIGAGPAGLTCAADLAKMGYEVTIYEALHQPGGVLTY--GIPEFRL--PKEILRKELK 212 Query: 89 EAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIR 148 + G+++ K D + T I+ L + Sbjct: 213 KLSLLGVEI--------------KTDHIVGKTITIQELLQ-------------------- 238 Query: 149 VTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTG----------AL 198 + + + TG+ P I + S A Sbjct: 239 -----------------EYDAVFIGTGAGTPKLPNIPGINLNGIYSANEFLTRINLMKAY 281 Query: 199 SLKEIP------KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQ 252 E K++ +IG G ++ RLG++VT+ + + D Sbjct: 282 KFPEYDTPIVVGKKVVVIGAGNTAMDAARSALRLGAEVTIAYRRGR----EDMTARIEEV 337 Query: 253 KFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTK---------------TNKQENLEA 297 K +++G+ F + +++ NV + E K T + +EA Sbjct: 338 KHAEEEGVKFMFFVNPVEFIGDENGNVKAVKFEKMKPLEERDSRGKRKIVGTGEYITVEA 397 Query: 298 EVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKA 357 + +++A+G+ P L L+VD+ GR+V+D+ + P + GD G A Sbjct: 398 DTVIIAIGQTPN-KVLWRATPELKVDEWGRIVVDENLMTSIPGVFAGGDAIRGEATVILA 456 Query: 358 EEEGIAAVEML 368 +G A + + Sbjct: 457 MGDGRKAAKAI 467 Score = 49.2 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 30/152 (19%), Positives = 53/152 (34%), Gaps = 33/152 (21%) Query: 184 IEIDEEKIVSSTGALS----LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQI 239 + E + L +K K++ IIG G GL + +++G +VT+ E Q Sbjct: 130 ADYAREHGIDDELLLEEIKGIKRNGKKVAIIGAGPAGLTCAADLAKMGYEVTIYEALHQP 189 Query: 240 GA---------SMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTN 290 G + E+ + K L G++ K V T T Sbjct: 190 GGVLTYGIPEFRLPKEILRKELKKLSLLGVEIKTDHIVGK----------------TITI 233 Query: 291 KQENLEAEVLLVAVG----RRPYIAGLGAEKI 318 ++ E + + + G + P I G+ I Sbjct: 234 QELLQEYDAVFIGTGAGTPKLPNIPGINLNGI 265 >2V3B-A nrPDB Length = 384 Score = 114 bits (286), Expect = 9e-26, Method: Composition-based stats. Identities = 61/329 (18%), Positives = 118/329 (35%), Gaps = 40/329 (12%) Query: 138 NGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFP--GIEIDEEKIVSST 195 N T++ + E+ + +++++A G+E P G D ++ Sbjct: 74 NARILTHTRVTGIDPGHQRIWIGEEEV-RYRDLVLAWGAEPIRVPVEGDAQDALYPINDL 132 Query: 196 GALSLKEIP----KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMD-GEVAKA 250 + +R+ ++G G+IG E + S G ++ VV Q+ + AKA Sbjct: 133 EDYARFRQAAAGKRRVLLLGAGLIGCEFANDLSSGGYQLDVVAPCEQVMPGLLHPAAAKA 192 Query: 251 TQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYI 310 Q L+ G+ F L + S K+ + +E + D E + ++++ AVG RP Sbjct: 193 VQAGLEGLGVRFHLGPVLASLKKAGEG--LEAHLSDG-----EVIPCDLVVSAVGLRPRT 245 Query: 311 AGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDV--TFGPMLAHKA--EEEGIAAVE 366 A GL V++ +V+D + +I +GD G L + A + Sbjct: 246 E--LAFAAGLAVNR--GIVVDRSLRTSHANIYALGDCAEVDGLNLLYVMPLMACARALAQ 301 Query: 367 MLKTGHGHVNYNNIPSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDT 426 L V Y +P + + + P + + Sbjct: 302 TLAGNPSQVAYGPMPVTVKTP----ACPL-------------VVSPPPRGMDGQWLVEGS 344 Query: 427 EGFVKILIDSKTERILGAHIIGPNAGEMI 455 +K+L R++G + G E + Sbjct: 345 GTDLKVLCRDTAGRVIGYALTGAAVNEKL 373 >3R9U-A nrPDB Length = 315 Score = 113 bits (283), Expect = 2e-25, Method: Composition-based stats. Identities = 66/329 (20%), Positives = 113/329 (34%), Gaps = 50/329 (15%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHL 82 N DV IIGGGPAG A + A + G + ++G GG + I + + + + Sbjct: 1 SNAMLDVAIIGGGPAGLSAGLYATRGGLKNVVMFEKGMPGGQITSSSEIENYPGV--AQV 58 Query: 83 FHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFE 142 GI F K + V G+E + K + +GSF Sbjct: 59 MD---------GISFMAPWSEQCMRF-GLKHEMV-----GVEQILKNS-------DGSF- 95 Query: 143 DETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTP--FPGIEIDEEKIVSSTGALS- 199 ++ K +IV TGS F G + K VS+ Sbjct: 96 -------------TIKLEGGKTELAKAVIVCTGSAPKKAGFKGEDEFFGKGVSTCATCDG 142 Query: 200 LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQG 259 K + ++GGG LE + + SK+ ++ + + A+ +K K + Sbjct: 143 FFYKNKEVAVLGGGDTALEEALYLANICSKIYLIHRRDEFRAA-----PSTVEKVKKNEK 197 Query: 260 LDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIG 319 ++ S V DK V V K +L + VG L + Sbjct: 198 IELITSASVDEVY--GDKMGVAGVKVKLKDGSIRDLNVPGIFTFVGLNVRNEILKQDDSK 255 Query: 320 L--EVDKRGRLVIDDQFNSKFPHIKVVGD 346 +++ G++ +D + + + GD Sbjct: 256 FLCNMEEGGQVSVDLKMQTSVAGLFAAGD 284 >5TWC-A nrPDB Length = 344 Score = 113 bits (282), Expect = 2e-25, Method: Composition-based stats. Identities = 58/351 (16%), Positives = 119/351 (33%), Gaps = 49/351 (13%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLF---- 83 DV IIGGGP+G A+ A + ++ + +LGG P K + + + Sbjct: 3 DVTIIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGKMRI---YPEKIIWDIGGIAPKPC 59 Query: 84 HQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFED 143 H++ + K+G+ ++ +N K +K + Sbjct: 60 HEILKDTIKQGLYFKPEVHLNERVVDIRKKAERHFEVETEAGEIYTSKAVIIAIGAGIIN 119 Query: 144 ETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEI 203 ++ V V+ + T + + Sbjct: 120 PKQLDVKGVERYQLTNLHYVVQSYRRF--------------------------------K 147 Query: 204 PKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFK 263 K + I GGG L+ +++ VTVV + D +A + + + Sbjct: 148 DKDVLISGGGNTALDWAHDIAKIAKSVTVVYRKE------DVSGHEAMKTLVTDLNVKLC 201 Query: 264 LSTKVISAKRNDDKN-VVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEV 322 T++ NDD+ + E+V+E ++ + ++ + ++++ G L L++ Sbjct: 202 PKTRIKYLVGNDDETHISEVVLEHVESGDRHTVKFDDVIISHGFDRCNTLLSETSSKLDM 261 Query: 323 DKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHK---AEEEGIAAVEMLKT 370 R+ + P I GD+ + +H A +G A + KT Sbjct: 262 HDDCRVKGFGNTTTSIPGIYACGDIVYHDAKSHLIASAFSDGANAANLAKT 312 >2WHD-A nrPDB Length = 351 Score = 111 bits (279), Expect = 6e-25, Method: Composition-based stats. Identities = 62/353 (17%), Positives = 109/353 (30%), Gaps = 68/353 (19%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGK----LGG---TCLNVGCIPSK-ALLNNS 80 V IIG GPA + AAI AA+ E GG T +V P + Sbjct: 33 VCIIGSGPAAHTAAIYAARAELKPVLFEGWMANDIAAGGQLTTTTDVENFPGFPTGIMGI 92 Query: 81 HLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGS 140 L ++ + G + Sbjct: 93 DLMDNCRAQSVRFGTN-------------------------------------------- 108 Query: 141 FEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGS--EVTPFPGIEIDEEKIVSSTGAL 198 ET V + + ++VATG+ F G + + +S+ Sbjct: 109 ILSETVTEVDFSARPFRVTSDSTTVLADTVVVATGAVARRLYFSGSDTYWNRGISACAVC 168 Query: 199 SLKEIP---KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFL 255 K + +IGGG +E G+ ++ GS+V ++ + AS + + L Sbjct: 169 DGAAPIFRNKPIAVIGGGDSAMEEGNFLTKYGSQVYIIHRRNTFRASKIMQ-----ARAL 223 Query: 256 KKQGLDFKLSTKVIS-AKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLG 314 + ++V+ + + V++ T + +L+ L A+G P L Sbjct: 224 SNPKIQVVWDSEVVEAYGGAGGGPLAGVKVKNLVTGEVSDLQVSGLFFAIGHEPATKFLN 283 Query: 315 AEKIGLEVDKRGRLVIDDQF-NSKFPHIKVVGDVTFGPML-AHKAEEEGIAAV 365 + LE+ G + ++ + GDV A A G A Sbjct: 284 GQ---LELHADGYVATKPGSTHTSVEGVFAAGDVQDKKYRQAITAAGSGCMAA 333 >4JNQ-A nrPDB Length = 345 Score = 111 bits (277), Expect = 9e-25, Method: Composition-based stats. Identities = 67/359 (18%), Positives = 118/359 (32%), Gaps = 72/359 (20%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCL---NVGCIPSKAL-LNN 79 + V++IG GPAGY AAI AA+ + + GG + +V P A + Sbjct: 24 QRHAPVIVIGSGPAGYTAAIYAARAMLKPVVIAGLQQ-GGQLMITTDVENYPGYAEPVQG 82 Query: 80 SHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNG 139 + QM +A+ G + DI V Sbjct: 83 PWMMEQMARQAENVGAQIVHDIITEV---------------------------------- 108 Query: 140 SFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPF------PGIEIDEEKIVS 193 ET +R + G GT I +I+ATG++ + + Sbjct: 109 ----ETTVRPFRLKGDSGT-----IYTCDALIIATGAQAKWLGLESEQTFMGGGVSACAT 159 Query: 194 STGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQK 253 G K + ++GGG +E S + VT+V + A + + Sbjct: 160 CDGFFY---RGKDVVVVGGGNTAVEEALYLSHIAKSVTIVHRRDGFRAEKIMQ-----DR 211 Query: 254 FLKKQGLDFKLSTKVISAKRND-----DKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRP 308 L ++ + ++ + + V + +++ T + + + +A+G P Sbjct: 212 LLSRENVSVVWNSVIDEILGTEARPPMGATVTGVRLKNIVTGETQERATHGVFIAIGHAP 271 Query: 309 YIAGLGAEKIGLEVDKRGRLVID-DQFNSKFPHIKVVGDVTFGPML-AHKAEEEGIAAV 365 ++ + L+ G L D + P I GDVT A A G A Sbjct: 272 AVSLFEGK---LKQKPNGYLWTAPDSTATDVPGIFAAGDVTDDIYRQAVTAAGMGCMAA 327 >5YGQ-A nrPDB Length = 342 Score = 108 bits (269), Expect = 7e-24, Method: Composition-based stats. Identities = 56/344 (16%), Positives = 110/344 (31%), Gaps = 63/344 (18%) Query: 21 LTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLN------VGCIPSK 74 +T DV+I+G GP G A + L V+ K+GG C + IP Sbjct: 1 MTETIKTDVLIVGAGPCGLFAVFELGLLDVKAHLVDILDKVGGQCAELYPEKPIYDIPGI 60 Query: 75 ALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTY 134 ++ L + + + + +++ + Sbjct: 61 PMVTGHGLTEALMEQIKPF------NPTFHLSEMVEN----------------------- 91 Query: 135 YKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGS-----EVTPFPGIEIDEE 189 + G T + + ++VA G + P PG+E E Sbjct: 92 ------------VEKIGDPGFRVTTNAGKVFECTVLVVAAGGGSFLPKRPPVPGVEAYEG 139 Query: 190 KIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAK 249 V K + I+GGG L+ + + +T+V + + + Sbjct: 140 TSVHYAVRKMEDFRGKDILIVGGGDSALDWTLNLNPIAKSMTLVHRRDDFRGA--PHSVE 197 Query: 250 ATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPY 309 ++ + LD K+ N + + D T++ ++ + +L G Sbjct: 198 QMRQLVASGKLDLKIGQITELQGDNGQLTGATVKLNDNTTSQ---IKCDAMLPFFGL--- 251 Query: 310 IAGLG-AEKIGLEVDKRGRLVIDD-QFNSKFPHIKVVGDVTFGP 351 LG GL++ + + +D F + P I +GD+ P Sbjct: 252 TMKLGPVANWGLDL-ENNLIPVDTGTFETNVPGIFAIGDINTYP 294 >1XHC-A nrPDB Length = 367 Score = 106 bits (266), Expect = 2e-23, Method: Composition-based stats. Identities = 66/387 (17%), Positives = 139/387 (35%), Gaps = 83/387 (21%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIP--SKALLNNSHLFHQM 86 VVI+G GP G+ A + +Q + ++K +P SK +L SH Sbjct: 11 VVIVGNGPGGFELAKQLSQT-YEVTVIDKEP-----------VPYYSKPML--SHYIAGF 56 Query: 87 HTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTY-YKGNGSFEDET 145 + ++ ++K + D Sbjct: 57 IPRNRLF------PYSLDW---------------------YRKRGIEIRLAEEAKLIDR- 88 Query: 146 KIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPK 205 G + + E + +++ATG+ P I+ +E +++ I + Sbjct: 89 --------GRKVVITEKGEVPYDTLVLATGARARE-PQIK-GKEYLLTLRTIFDADRIKE 138 Query: 206 RLTIIG------GGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQG 259 + G GG IGLE+ + G V ++ +D E++ + L++ G Sbjct: 139 SIENSGEAIIIGGGFIGLELAGNLAEAGYHVKLIHRGAMFL-GLDEELSNMIKDMLEETG 197 Query: 260 LDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIG 319 + F L+++++ A V+ ++ + + + A+G P + A + G Sbjct: 198 VKFFLNSELLEANEEG-------VLTNSGFIEGKVK-----ICAIGIVPNVD--LARRSG 243 Query: 320 LEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPML----AHKAEEEGIAAVEMLKTGHGHV 375 + + ++IDD F + + +GD + A A E+ ++LK Sbjct: 244 IHTGR--GILIDDNFRTSAKDVYAIGDCAEYSGIIAGTAKAAMEQARVLADILKGEPRRY 301 Query: 376 NYNNIPSV-MYSHPEVAWVGKTEEQLK 401 N+ +V + ++A +G T+ + K Sbjct: 302 NFKFRSTVFKFGKLQIAIIGNTKGEGK 328 >5KVH-A nrPDB Length = 543 Score = 86.9 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 56/294 (19%), Positives = 111/294 (37%), Gaps = 50/294 (17%) Query: 137 GNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTG 196 G + +++ D + + + + + ++ATG I+ ++ S T Sbjct: 148 GVAVLTGKKVVQLDVRDNM-VKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTT 206 Query: 197 AL-------SLKEIP---KRLTIIGGGIIGLEMGSVY----SRLGSKVT-VVEFQPQIGA 241 SL++I K +TIIGGG +G E+ LG++V + + +G Sbjct: 207 LFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARALGTEVIQLFPEKGNMGK 266 Query: 242 SMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLL 301 + ++ T + ++++G+ + V S + K ++++ +E + ++ Sbjct: 267 ILPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSSGKLLIKLK-------DGRKVETDHIV 319 Query: 302 VAVGRRPYIAGLGAEKIGLEVD-KRGRLVIDDQFNSKFPHIKVVGD--VTFGPMLAHK-- 356 AVG P + A+ GLE+D G ++ + ++ +I V GD + L + Sbjct: 320 AAVGLEPNVE--LAKTGGLEIDSDFGGFRVNAELQAR-SNIWVAGDAACFYDIKLGRRRV 376 Query: 357 -----AEEEGIAAVEMLKTGHGH--------------VNYNNIPSVMYSHPEVA 391 A G A E + V Y I V S P V Sbjct: 377 EHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVG 430 >3KLJ-A nrPDB Length = 385 Score = 83.4 bits (205), Expect = 2e-16, Method: Composition-based stats. Identities = 76/438 (17%), Positives = 143/438 (32%), Gaps = 103/438 (23%) Query: 25 KSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFH 84 KS ++I+G GPAG+ AA A G C ++ ++N+ Sbjct: 8 KSTKILILGAGPAGFSAAKAAL----------------GKCDDI------TMINS----- 40 Query: 85 QMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKG-NGSFED 143 +N I AK+ ++ + ++KN + + D Sbjct: 41 --EKYLPYYRPRLNEII---------AKNKSIDDILIKKNDWYEKNNIKVITSEFATSID 89 Query: 144 ETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSS-TGALSLKE 202 VT G + + + +I+A+GS DE + S AL +K+ Sbjct: 90 PNNKLVTLKSGEK--------IKYEKLIIASGSIANKIKVPHADEIFSLYSYDDALKIKD 141 Query: 203 IPK---RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIG-ASMDGEVAKATQKFLKKQ 258 K + IIGGGI+G+E+ G+ ++ +D + + L + Sbjct: 142 ECKNKGKAFIIGGGILGIELAQAIIDSGTPASIGIILEYPLERQLDRDGGLFLKDKLDRL 201 Query: 259 GLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKI 318 G+ ++ + D + + ++ AVG +P + + Sbjct: 202 GIKIYTNSN---FEEMGD-----------------LIRSSCVITAVGVKPNLDFIK---- 237 Query: 319 GLEVDKRGRLVIDDQFNSKFPHIKVVGDVTF----GPMLAHKAEEEGIAAVEMLKTGHGH 374 E+ + ++++D + I GDV P L + A ++G A Sbjct: 238 DTEIASKRGILVNDHMETSIKDIYACGDVAEFYGKNPGLINIANKQGEVAGLNACGEDAS 297 Query: 375 VNYNNI---PSVMYSHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVK 431 Y+ I P + S + G E K+ + Sbjct: 298 --YSEIIPSPILKVSGISIISCGDIE-----NNKPSKVFRSTQEDKY------------- 337 Query: 432 ILIDSKTERILGAHIIGP 449 I+ K +I A +IG Sbjct: 338 IVCMLKENKIDAAAVIGD 355 >5MIU-A nrPDB Length = 535 Score = 82.3 bits (202), Expect = 5e-16, Method: Composition-based stats. Identities = 57/295 (19%), Positives = 108/295 (36%), Gaps = 49/295 (16%) Query: 136 KGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSST 195 G + K+ V G + + + + ++ATG I+ ++ S T Sbjct: 144 NGGVAVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGAEVKSRT 203 Query: 196 GAL-------SLKEIP---KRLTIIGGGIIGLEMGSVYSRL----GSKVT-VVEFQPQIG 240 +L++I K +T+IG G +G E+ R G +V + + +G Sbjct: 204 TLFRKIGDFRALEKISREVKSITVIGEGFLGSELACALGRKSQASGIEVIQLFPEKGNMG 263 Query: 241 ASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVL 300 + ++ T + +K++G+ + V S + I ++D + +E + + Sbjct: 264 KILPQYLSNWTMEKVKREGVKVMPNAIVQSV--GVSGGRLLIKLKDGR-----KVETDHI 316 Query: 301 LVAVGRRPYIAGLGAEKIGLEVD-KRGRLVIDDQFNSKFPHIKVVGD--VTFGPMLAHK- 356 + AVG P + A+ GLE+D G ++ + ++ +I V GD + L + Sbjct: 317 VTAVGLEPNVE--LAKTGGLEIDSDFGGFRVNAELQAR-SNIWVAGDAACFYDIKLGRRR 373 Query: 357 ------AEEEGIAAVEMLKTGHGH--------------VNYNNIPSVMYSHPEVA 391 A G A E + V Y I V S P V Sbjct: 374 VEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVG 428 >2VDC-G nrPDB Length = 456 Score = 81.9 bits (201), Expect = 7e-16, Method: Composition-based stats. Identities = 42/235 (17%), Positives = 84/235 (35%), Gaps = 40/235 (17%) Query: 169 NIIVATG---SEVTPFPGIEIDE-----EKIVSSTGAL-----------SLKEIPKRLTI 209 ++VATG + PG + + + +S SL K + + Sbjct: 210 AVLVATGVYKARDIKAPGSGLGNIVAALDYLTTSNKVSLGDTVEAYENGSLNAAGKHVVV 269 Query: 210 IGGGIIGLEMGSVYSRLGS-KVTVVEFQPQI-GASMDGEVAKATQKFLKKQGLDFKLSTK 267 +GGG ++ R G+ V + + + EVA +++G++F Sbjct: 270 LGGGDTAMDCVRTAIRQGATSVKCLYRRDRKNMPGSQREVA-----HAEEEGVEFIWQAA 324 Query: 268 VISAKRNDDKNVVEIV-----VEDTKT--------NKQENLEAEVLLVAVGRRPYIAGLG 314 + V V V D + ++A++++ A+G P Sbjct: 325 PEGFTGDTVVTGVRAVRIHLGVADATGRQTPQVIEGSEFTVQADLVIKALGFEPEDLPNA 384 Query: 315 AEKIGLEVDKRGRLVIDDQFN-SKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEML 368 ++ L+V + G L++D + + + GD+ G L A +G A E + Sbjct: 385 FDEPELKVTRWGTLLVDHRTKMTNMDGVFAAGDIVRGASLVVWAIRDGRDAAEGI 439 >4G74-A nrPDB Length = 502 Score = 74.6 bits (182), Expect = 9e-14, Method: Composition-based stats. Identities = 60/296 (20%), Positives = 100/296 (33%), Gaps = 57/296 (19%) Query: 128 KKNKVTYYKGNGSFE--DETKIRVT----------PVDGLEGTVKEDHILDVKNIIVATG 175 KK VTYY+ + D + + P + L E + +I A G Sbjct: 107 KKGNVTYYEAEATSINPDRNTVTIKSLSAVSQLYQPENHLGLHQAEPAEIKYDYLISAVG 166 Query: 176 SEVT--PFPGI--------EIDEEKIVSSTGALSLKE---IPK------RLTII------ 210 +E PG+ EI + T A +L++ +PK RL I Sbjct: 167 AEPNTFGIPGVTDYGHFLKEIPNSLEIRRTFAANLEKANLLPKGDPERRRLLSIVVVGGG 226 Query: 211 -----GGG----IIGLEMGSVYSRLGSKV--TVVEFQPQIGASMDGEVAKATQKFLKKQG 259 G + ++ L +V +VE P + + +++ Q L+ Sbjct: 227 PTGVEAAGELQDYVHQDLRKFLPALAEEVQIHLVEALPIVLNMFEKKLSSYAQSHLENTS 286 Query: 260 LDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVG--RRPYIAGLGAEK 317 + L T V + + + + ED K +E + L+ A G RP I L + Sbjct: 287 IKVHLRTAVAKVEEK--QLLAKTKHEDGKI-TEETIPYGTLIWATGNKARPVITDLFKKI 343 Query: 318 IGLEVDKRGRLVIDDQFNS-KFPHIKVVGDV--TFGPMLAHKAEEEGIAAVEMLKT 370 KRG L ++D +I +GD P A A +E + Sbjct: 344 PEQNSSKRG-LAVNDFLQVKGSNNIFAIGDNAFAGLPPTAQVAHQEAEYLAKNFDK 398 >5NA1-A nrPDB Length = 408 Score = 69.2 bits (168), Expect = 4e-12, Method: Composition-based stats. Identities = 57/290 (19%), Positives = 110/290 (37%), Gaps = 63/290 (21%) Query: 123 IELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATG--SEVTP 180 +E + KK+KV + + + D +V G I D ++VA G SE Sbjct: 73 VESVLKKDKVNFVQAEVTKIDRDAKKVETNQG---------IYDFDILVVALGFVSETFG 123 Query: 181 FPGIE---IDEEKIVSSTGA-------LSLKEIPK-------RLTIIGGGIIGLEMGSVY 223 G++ E ++++ + K + + G G G+E Sbjct: 124 IEGMKDHAFQIENVITARELSRHIEDKFANYAASKEKDDNDLSILVGGAGFTGVEFLGEL 183 Query: 224 S-------------RLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVIS 270 + + K+T VE P++ E+ +L+ +G++FK++T +++ Sbjct: 184 TDRIPELCSKYGVDQNKVKITCVEAAPKMLPMFSEELVNHAVSYLEDRGVEFKIATPIVA 243 Query: 271 AKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVI 330 N+ VVE+ +++ L A + A G R + G+ KRGR+V Sbjct: 244 C--NEKGFVVEV------DGEKQQLNAGTSVWAAGVRG-SKLMEESFEGV---KRGRIVT 291 Query: 331 DDQFNSK-FPHIKVVGDVTFG---------PMLAHKAEEEGIAAVEMLKT 370 + +I V+GD + P A A ++G + + +K Sbjct: 292 KQDLTINGYDNIFVIGDCSAFIPAGEERPLPTTAQIAMQQGESVAKNIKR 341 Score = 31.1 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 23/130 (17%), Positives = 46/130 (35%), Gaps = 30/130 (23%) Query: 205 KRLTIIGGGIIGLEMGSVYSRL----GSKVTVV-------------EFQPQIGASMDGEV 247 K++ ++G G GL+ + + +++T++ E D V Sbjct: 12 KKVLVLGAGYAGLQTVTKLQKAISTEEAEITLINKNEYHYEATWLHEASAGTLNYED--V 69 Query: 248 AKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRR 307 + LKK ++F +V R+ K Q + ++L+VA+G Sbjct: 70 LYPVESVLKKDKVNFV-QAEVTKIDRDAKKVET----------NQGIYDFDILVVALGFV 118 Query: 308 PYIAGLGAEK 317 G+ K Sbjct: 119 SETFGIEGMK 128 >5JWC-A nrPDB Length = 521 Score = 66.5 bits (161), Expect = 3e-11, Method: Composition-based stats. Identities = 32/232 (13%), Positives = 77/232 (33%), Gaps = 47/232 (20%) Query: 165 LDVKNIIVATGSEVT--PFPGIEIDEEKIVSSTGALSLKE----------IPK------- 205 L +I+A G++ G++ + AL +++ +P Sbjct: 127 LFYDYLIIAVGAKTNTFNINGVDKYAYFVKDIDDALKIRKKFLDILEKCTLPNISNEEKK 186 Query: 206 ---RLTIIGGGIIGLEM-GSVYSRLGSKVTV-------------VEFQPQIGASMDGEVA 248 + ++GGG G+E+ + +V + +E + + ++ Sbjct: 187 KMLHVAVVGGGPTGVEVTAEFADFINKEVKINYKDIFNFISISIIEGGNNLLPTFTQNIS 246 Query: 249 KATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRP 308 T++ ++ + VI ++ + N+++ L +L+ A G Sbjct: 247 DFTKENFHNLNINVLTNYYVIDVDKHSFHIQSSL-----NKNEKKKLSYGLLIWASGL-A 300 Query: 309 YIAGLGAEKIGLEVDKRGRL-VIDDQFNS-KFP--HIKVVGDVTF-GPMLAH 355 + + V + +D++ P +I +GD P L H Sbjct: 301 QTTLIQKFLKTIPVQANNAILKVDEKLRVIGIPSNNIYAIGDCKKIQPKLLH 352 >4NTC-A nrPDB Length = 335 Score = 66.1 bits (160), Expect = 3e-11, Method: Composition-based stats. Identities = 55/350 (15%), Positives = 105/350 (30%), Gaps = 63/350 (18%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMH 87 DV+IIG GPAG A A+ L+ + +F Sbjct: 16 DVLIIGAGPAGLSTATGLARQ----------------------------LHTAVVFDS-- 45 Query: 88 TEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKI 147 G+ N + + N +L T N + E ++ Sbjct: 46 ------GVYRNAKTQH-MHNVLGWDHRNPAELRAAGRADLTTRYSTIQFQNSTIEAIRQV 98 Query: 148 RVTPVDGLEGTVKEDHILDVKNIIVATGSE--VTPFPGIEIDEEKIVSSTGALSLKEIPK 205 + E E H + +++ATG G + E Sbjct: 99 ETNQL--FEARDNEGHSWYGRKVVLATGVRDIPLDIEGYSECWANGIYHCLFCDGYEERG 156 Query: 206 --RLTIIGGGIIG-----LEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQ 258 + ++ G I L + + RL VT+ + A + A+ + + Sbjct: 157 QETVGVLALGPIANPARALHLARMALRLSESVTIYTNGNEQLAKEIQQAAE--ESPVGAS 214 Query: 259 GLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLG--AE 316 GL F+ + ++ D V + + ++++ + L P G A+ Sbjct: 215 GLKFEAR-PIRRFEKGDVAKTVIVHLGESESKTEGFLVYN---------PQTEVNGPFAK 264 Query: 317 KIGLEVDKRGRLVIDD-QFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAV 365 ++ L + + G ++ + + P + VGD A G A Sbjct: 265 QLALNMTEGGDILTTPPFYETSVPGVFAVGDCATPLKAVTPAVSMGSLAA 314 >4USR-A nrPDB Length = 361 Score = 64.6 bits (156), Expect = 9e-11, Method: Composition-based stats. Identities = 56/359 (15%), Positives = 115/359 (32%), Gaps = 85/359 (23%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMH 87 DV++IGGG A A + + ++++ GG L+ ++ LF Sbjct: 9 DVIVIGGGQAALTTAYFLRRTSLSYLLLDEQPGPGGAWLHA--------WDSLRLFSPAA 60 Query: 88 TEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFK---KNKVTYYKGNGSFEDE 144 + G + + ++D + L E ++ + V Sbjct: 61 WSSIA-GWPMPSPTEPGNPT----RNDVIDYLRR-YEDRYQFPIQRPVRVD--------- 105 Query: 145 TKIRVTPVDGLEGTVKEDHILDVKNIIVATGSE----VTPFPGIEIDEEKIVSSTGA-LS 199 VT +D L D + +I ATG+ + P+ G E+ + + S Sbjct: 106 ---TVTRLDDLWRVQAGDQQWLARAVISATGTWSKPFIPPYEGRELFQGAQIHSAHYRTP 162 Query: 200 LKEIPKRLTIIGGGIIGLEMGSVYSRLGS-----------------KVT---VVEFQ--- 236 KR+ ++GGG G V + L S +V + E Sbjct: 163 APFAGKRVMVVGGGNSG---AQVLAELSSVSETLWITQEPPAFLPDEVDGRVLFERATAR 219 Query: 237 ----------PQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVED 286 + V + +++G+ ++ Sbjct: 220 WKAQQEGRSIDEPAGGFGDIVMVPPVREARERGVLV------------AERPFARFTETG 267 Query: 287 TKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVG 345 + + ++ G RP + L ++G+ V+ G++ ++D K P++ +VG Sbjct: 268 VEWADGRRENLDAVIWCSGFRPALDHL--RELGV-VEADGKVQVEDTRVVKQPNLWLVG 323 >3UP5-A nrPDB Length = 545 Score = 63.8 bits (154), Expect = 2e-10, Method: Composition-based stats. Identities = 48/253 (18%), Positives = 84/253 (33%), Gaps = 35/253 (13%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCL-NVGCIPSKALLNNSHLFHQM 86 D V+IG G G A Q G +E +GGT N P L S+ + Sbjct: 11 DAVVIGAGVTGIYQAFLINQAGMKVLGIEAGEDVGGTWYWNR--YPGCRLDTESYAYG-- 66 Query: 87 HTEAQKRGIDVNGDIKINV---ANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFED 143 +GI + N + + A + F +VT + Sbjct: 67 --YFALKGIIPEWEWSENFASQPEMLRYVNRAADAMDVRKHYRF-NTRVTAARY------ 117 Query: 144 ETKIRVTPVDGLEGTVKEDHILDVKNIIVATG----SEVTPFPGIE-IDEEKIVSSTGAL 198 V E T+ + ++ + +I ATG S + GI+ E SS Sbjct: 118 -----VENDRLWEVTLDNEEVVTCRFLISATGPLSASRMPDIKGIDSFKGESFHSSRWPT 172 Query: 199 SLKEIP-------KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQP-QIGASMDGEVAKA 250 + P KR+ +IG G G+++ + + ++ V + P + ++K Sbjct: 173 DAEGAPKGVDFTGKRVGVIGTGATGVQIIPIAAETAKELYVFQRTPNWCTPLGNSPMSKE 232 Query: 251 TQKFLKKQGLDFK 263 L+ + Sbjct: 233 KMDSLRNRYPTIL 245 >4C5O-A nrPDB Length = 357 Score = 62.3 bits (150), Expect = 5e-10, Method: Composition-based stats. Identities = 51/335 (15%), Positives = 103/335 (30%), Gaps = 65/335 (19%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMH 87 DVV+IGGG +G A + G + ++ GG ++ + Sbjct: 5 DVVVIGGGQSGLSAGYFLRRSGLSYVILDAEASPGGA------------WQHAWHSLHLF 52 Query: 88 TEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIEL-----LFKKNKVTYYKGNGSFE 142 + A G + + V E + + +V G Sbjct: 53 SPA---GWSSIPGWPMPASQGPYPARAEVLAYLAQYEQKYALPVLRPIRVQRVSHFGE-- 107 Query: 143 DETKIRVTPVDGLEGTVKEDHILDVKNIIVATG----SEVTPFPGIEIDEEKIVSSTGAL 198 ++RV DG + + +I ATG + + G+E + S Sbjct: 108 ---RLRVVARDGRQWL--------ARAVISATGTWGEAYTPEYQGLESFAGIQLHSAHYS 156 Query: 199 SL-KEIPKRLTIIGGGIIGLEMGSVYSRLG--SKVTVVEFQPQIGASMDGEVAKATQKFL 255 + R+ IIGGG G + + + ++ T + + D + ++ Sbjct: 157 TPAPFAGMRVAIIGGGNSG---AQILAEVSTVAETTWITRTEPAFLADDVDGRVLFERAT 213 Query: 256 KK--------------QGL-DFKLSTKVISAKRNDDKNVVEIVVEDTKTN----KQENLE 296 ++ G D + V+ A+ V + T Sbjct: 214 ERWKAQQEGREPDLPPGGFGDIVMVPPVLDARARGVLAAVPPPARFSPTGMQWADGTERA 273 Query: 297 AEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVID 331 + ++ G RP ++ L + V +G++ +D Sbjct: 274 FDAVIWCTGFRPALSHLKGLDL---VTPQGQVEVD 305 >4FK1-A nrPDB Length = 304 Score = 62.3 bits (150), Expect = 5e-10, Method: Composition-based stats. Identities = 61/349 (17%), Positives = 108/349 (30%), Gaps = 67/349 (19%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLF 83 K D +IG GPAG A++ + A + Sbjct: 4 MKYIDCAVIGAGPAGLNASLVLGRARKQIALFDNNT------------------------ 39 Query: 84 HQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFED 143 ++ G IK G+ + K V YY+ Sbjct: 40 NRNRVTQNSHGFITRDGIKPEEFKEI------------GLNEVMKYPSVHYYE------- 80 Query: 144 ETKIRVTPVD-GLEGTVKEDHI-LDVKNIIVATG--SEVTPFPGIEIDEEKIVSSTGALS 199 +T + +T GL V +DH + +++ATG E P + K + S Sbjct: 81 KTVVMITKQSTGLFEIVTKDHTKYLAERVLLATGMQEEFPSIPNVREYYGKSLFSCPYCD 140 Query: 200 LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVE--FQPQIGASMDGEVAKATQKFLKK 257 E+ + II I +V + A+ E+++ L Sbjct: 141 GWELKDQPLII----ISENEDHTLHM----TKLVYNWSTDLVIATNGNELSQTIMDELSN 192 Query: 258 QGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEK 317 + + + I + + + ++ ++ A +V RP E+ Sbjct: 193 KNIPVITES--IRTLQGEGGYLKKVEFHSGLRIER----AGGFIVPTFFRPN---QFIEQ 243 Query: 318 IGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTF-GPMLAHKAEEEGIAAV 365 +G E+ G VIDD + +I + G+ T GP A +G A Sbjct: 244 LGCELQSNGTFVIDDFGRTSEKNIYLAGETTTQGPSSLIIAASQGNKAA 292 >4OVI-A nrPDB Length = 542 Score = 60.7 bits (146), Expect = 1e-09, Method: Composition-based stats. Identities = 37/247 (14%), Positives = 91/247 (36%), Gaps = 37/247 (14%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMH 87 DV+++G G +G A + +LG + +E G +GG N + + Sbjct: 18 DVLVVGAGFSGLYALYRLRELGRSVHVIETAGDVGG-----------VWYWNRYPGARCD 66 Query: 88 TEAQKRGIDVNGDI--KINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDET 145 E+ + + ++ + N ++ + ++ + + ++ +T++ T Sbjct: 67 IESIEYCYSFSEEVLQEWNWTERYASQPEILRYINFVADKFDLRSGITFH---------T 117 Query: 146 KIRVTPVDGLEGTVKED----HILDVKNIIVATGS-EVTPFPGIEIDEEKIVSSTGALSL 200 + D T D + + +I+A+G V P ++ + + Sbjct: 118 TVTAAAFDEATNTWTVDTNHGDRIRARYLIMASGQLSVPQLPNFPGLKDFAGNLYHTGNW 177 Query: 201 KEIP-----KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIG-----ASMDGEVAKA 250 P +R+ +IG G G+++ ++ +++ V + P A +D E Sbjct: 178 PHEPVDFSGQRVGVIGTGSSGIQVSPQIAKQAAELFVFQRTPHFAVPARNAPLDPEFLAD 237 Query: 251 TQKFLKK 257 +K + Sbjct: 238 LKKRYAE 244 >2TMD-A nrPDB Length = 729 Score = 59.6 bits (143), Expect = 3e-09, Method: Composition-based stats. Identities = 51/373 (13%), Positives = 105/373 (28%), Gaps = 88/373 (23%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHT 88 V+I+G GP+G AA + G+ + K+GG V +P Sbjct: 392 VLIVGAGPSGSEAARVLMESGYTVHLTDTAEKIGGHLNQVAALPG--------------- 436 Query: 89 EAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIR 148 G +++ ++T + K Sbjct: 437 ----LG-------------------------EWSYHRDYRETQIT------KLLKKNKES 461 Query: 149 VTPVDGLEGTVKEDHILDVKNIIVATGSEVT----------PFPGIEIDEEKIVSSTGAL 198 + T + +I+ATG+ P PG + ++ + Sbjct: 462 QLALGQKPMTADDVLQYGADKVIIATGARWNTDGTNCLTHDPIPGADASLPDQLTPEQVM 521 Query: 199 SL-KEIPKRLTIIGGG--IIGLEMGSVYSRLGSKVTV---VEFQP--QIGASMDGEVAKA 250 K+I KR+ I+ + + + G +VT+ V + + Sbjct: 522 DGKKKIGKRVVILNADTYFMAPSLAEKLATAGHEVTIVSGVHLANYMHFTLEYPNMMRRL 581 Query: 251 TQKFLKKQGLDFKLSTKVISAKR----NDDKNVV----EIVVEDTKTNKQENLEAEVLLV 302 + +++ G F + + D + D T+ + +E + L++ Sbjct: 582 HELHVEELGDHFCSRIEPGRMEIYNIWGDGSKRTYRGPGVSPRDANTSHRW-IEFDSLVL 640 Query: 303 AVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGI 362 GR K + + I ++GD P L A G Sbjct: 641 VTGRHSECTLWNELKA----------RESEWAENDIKGIYLIGD-AEAPRLIADATFTGH 689 Query: 363 AAVEMLKTGHGHV 375 ++ + + Sbjct: 690 RVAREIEEANPQI 702 Score = 46.1 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 17/110 (15%), Positives = 38/110 (34%), Gaps = 2/110 (1%) Query: 206 RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLS 265 + I+G G G E V G V + + +IG ++ A Sbjct: 391 SVLIVGAGPSGSEAARVLMESGYTVHLTDTAEKIGGHLNQVAALPGLGEWSYH--RDYRE 448 Query: 266 TKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGA 315 T++ + + ++ + + + + A+ +++A G R G Sbjct: 449 TQITKLLKKNKESQLALGQKPMTADDVLQYGADKVIIATGARWNTDGTNC 498 >1PS9-A nrPDB Length = 671 Score = 58.4 bits (140), Expect = 7e-09, Method: Composition-based stats. Identities = 46/231 (19%), Positives = 72/231 (31%), Gaps = 60/231 (25%) Query: 3 RIRSLLNNKRAFSST-VRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKL 61 ++ S L N RA T + L + ++ ++G GPAG AI AA G + ++ Sbjct: 349 KVTSCLVNPRACHETKMPILPAVQKKNLAVVGAGPAGLAFAINAAARGHQVTLFDAHSEI 408 Query: 62 GGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTG 121 GG IP K + + Sbjct: 409 GGQFNIAKQIPGKE-----EFYETLRY--------------------------------- 430 Query: 122 GIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPF 181 + + VT L TV D + I+A+G Sbjct: 431 -YRRMIEVTGVTL-------------------KLNHTVTADQLQAFDETILASGIVPRTP 470 Query: 182 PGIEIDEEKIVSSTGALSLKE-IPKRLTIIGGGIIGLEMGSVYSRLGSKVT 231 P ID K++S L K + ++ IIG G IG + S+ G + Sbjct: 471 PIDGIDHPKVLSYLDVLRDKAPVGNKVAIIGCGGIGFDTAMYLSQPGESTS 521 Score = 44.9 bits (105), Expect = 7e-05, Method: Composition-based stats. Identities = 19/120 (15%), Positives = 40/120 (33%), Gaps = 32/120 (26%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMD-----------GEVAKATQK 253 K L ++G G GL + G +VT+ + +IG + E + ++ Sbjct: 374 KNLAVVGAGPAGLAFAINAAARGHQVTLFDAHSEIGGQFNIAKQIPGKEEFYETLRYYRR 433 Query: 254 FLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGL 313 ++ G+ KL+ V + + + ++A G P + Sbjct: 434 MIEVTGVTLKLNHTVTA---------------------DQLQAFDETILASGIVPRTPPI 472 >6JDK-A nrPDB Length = 544 Score = 56.9 bits (136), Expect = 2e-08, Method: Composition-based stats. Identities = 39/255 (15%), Positives = 82/255 (32%), Gaps = 22/255 (8%) Query: 15 SSTVRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSK 74 SS + + D +I+G G G + Q GF E +GG C P Sbjct: 6 SSQTQKNDDAEVFDALIVGAGFNGIYQLHRLRQEGFKVRLFEAGADMGGI-WYWNCYPGA 64 Query: 75 ALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTY 134 + ++ ++ E + + ++ K+L ++ F Sbjct: 65 RVDSHIPIYEFSIEELWRD-WNWTERFPA-WDELRRYFHYVDKKLDLSRDIRFGMR---- 118 Query: 135 YKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATG-SEVTPFPGIEIDEEKIVS 193 F+ D + ++ + I+ TG + P + E Sbjct: 119 -VSAAEFD-------EARDQWVIRTTDGTVVRARFFILCTGFASKPYIPNYKGLESFAGE 170 Query: 194 STGALSLKE-----IPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQI-GASMDGEV 247 S + KR+ ++G G G+++ S+ + +TV + P + ++ Sbjct: 171 SFHTGLWPQEGASFTGKRVGVVGTGASGVQVVQEASKDAAHLTVFQRTPILALPMQQRKL 230 Query: 248 AKATQKFLKKQGLDF 262 TQ+ +K + Sbjct: 231 DVETQQRMKADYPEI 245 >6A37-A nrPDB Length = 552 Score = 56.5 bits (135), Expect = 3e-08, Method: Composition-based stats. Identities = 37/225 (16%), Positives = 71/225 (31%), Gaps = 26/225 (11%) Query: 21 LTINKSHDVVIIGGGPAGYVAAIKAAQ-LGFNTACVEKRGKLGGTCLNVGCIPSKALLNN 79 +T D +IIG G G + K ++ ++GGT N Sbjct: 21 MTQKMDFDAIIIGAGFGGLYSLKKLRDDFNLKVRAFDRATEVGGT----------WFWNQ 70 Query: 80 -SHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGN 138 T D ++ + ++ D + L + + + + G Sbjct: 71 YPGALSDSETHLYCYSWDKELLQEMEIKRKYISQPDVLAYLKRVADKHDLRKDIQFETGI 130 Query: 139 --GSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATG----SEVTPFPGIE-IDEEKI 191 F++E T + D + +I A G + GIE E Sbjct: 131 RSAYFDEENSF-------WNVTTENDEKFTARFLITALGLLAAPNLPKIKGIETFKGELH 183 Query: 192 VSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQ 236 +S + KR+ +IG G G+++ + + +TV + Sbjct: 184 HTSRWPKDVTFSGKRVGVIGTGSTGVQVITAIASQVKHLTVFQRS 228 >5NMX-A nrPDB Length = 425 Score = 54.6 bits (130), Expect = 9e-08, Method: Composition-based stats. Identities = 49/315 (15%), Positives = 98/315 (31%), Gaps = 57/315 (18%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHT 88 V ++G GP+G AA Q GF E+ +GGT N + M Sbjct: 4 VAVLGAGPSGLTAARYLKQAGFEVMVFERYHHVGGT------------WNYTD-ETWMSE 50 Query: 89 EAQKRGIDVNGDIKINVAN-FQKAKDDAVKQLTGGI---ELLFK--KNKVTYYKGNGSFE 142 + + + ++ +N+ D + G + + K N + + Sbjct: 51 DGRPVYSSMYQNLFVNLPKELMAFPDFPFHDIEGSYVPSKEVLKYFDNFTDAFDLRKLIK 110 Query: 143 DETKIRVT-------PVDGLEGTVKEDHILDVKNIIVATG-SEVTPFPGIEIDEEKIVSS 194 + + V + T +H + ++V TG + +P +E Sbjct: 111 LQHHVENVRPCESGWLVTVTDLTTMVEHSFEFDAVVVCTGQTWCPLYPDVEGRSFFRGRL 170 Query: 195 TGALSL----KEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKA 250 T A KR+ I+G G G +M S + +V + + ++ Sbjct: 171 THAHEFRSPEPFRNKRVLIVGAGPSGHDMALHISYVSKEVFL--SRKELKP--------- 219 Query: 251 TQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYI 310 ++ V + + + + + + +L G R Sbjct: 220 ---------VEGLFPDNVTE-----KPLLTSLSEYTAHFSDGTSTDVDEILYCTGYRYRF 265 Query: 311 AGLGAEKIGLEVDKR 325 L E G+ VD++ Sbjct: 266 PFLSPEC-GVTVDEK 279 Score = 36.1 bits (82), Expect = 0.037, Method: Composition-based stats. Identities = 10/39 (25%), Positives = 18/39 (46%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASM 243 +R+ ++G G GL + G +V V E +G + Sbjct: 2 RRVAVLGAGPSGLTAARYLKQAGFEVMVFERYHHVGGTW 40 >2CVJ-A nrPDB Length = 180 Score = 53.8 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 35/170 (20%), Positives = 59/170 (34%), Gaps = 23/170 (13%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVE----------FQPQIGASMDGEVAKATQKFLK 256 + ++GGG GL +R G KV V++ P +D + + L+ Sbjct: 4 VIVVGGGPSGLSAALFLARAGLKVLVLDGGRSKVKGVSRVPNYPGLLDEPSGEELLRRLE 63 Query: 257 KQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAE 316 + + K D V V + K AE LL+ + P + L Sbjct: 64 AHARRYGAEVRPGVVKGVRDMGGVFEVETEEGVEK-----AERLLLCTHKDPTLPSL--- 115 Query: 317 KIGLEVDKRG-RLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAV 365 L + +RG + D+ + +P + G V G + H G A Sbjct: 116 ---LGLTRRGAYIDTDEGGRTSYPRVYAAG-VARGKVPGHAIISAGDGAY 161 Score = 49.5 bits (117), Expect = 3e-06, Method: Composition-based stats. Identities = 24/107 (22%), Positives = 46/107 (42%), Gaps = 9/107 (8%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVE-KRGKLGGTCLNVGCIPSKALL----NNS 80 DV+++GGGP+G AA+ A+ G ++ R K+ G V +P+ L + Sbjct: 1 MWDVIVVGGGPSGLSAALFLARAGLKVLVLDGGRSKVKG----VSRVPNYPGLLDEPSGE 56 Query: 81 HLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLF 127 L ++ A++ G +V + V + + ++ E L Sbjct: 57 ELLRRLEAHARRYGAEVRPGVVKGVRDMGGVFEVETEEGVEKAERLL 103 >3H8L-A nrPDB Length = 409 Score = 51.1 bits (121), Expect = 1e-06, Method: Composition-based stats. Identities = 49/307 (15%), Positives = 98/307 (31%), Gaps = 50/307 (16%) Query: 116 VKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATG 175 V +L + + + + +G D V +E + +IV G Sbjct: 55 VDELKVDLSEALPEKGIQFQEGTVEKIDAKSSMVYYTKPDGSMAEE----EYDYVIVGIG 110 Query: 176 SEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEF 235 + + ++ ++ S ++ ++L GG I + G Y K V E Sbjct: 111 AHLAT-ELVKGWDKYGYSVCEPEFATKLREKLESFQGGNIAIGSGPFYQGHNPKPKVPE- 168 Query: 236 QPQIGASMDG-------EVAKATQKFLKKQGLDFKLSTKV-------------------- 268 + D E++ + KK+G+ K+ V Sbjct: 169 --NFVPNADSACEGPVFEMSLMLHGYFKKKGMLDKVHVTVFSPGEYLSDLSPNSRKAVAS 226 Query: 269 ----ISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEV-D 323 + K + + EI + K + A++ ++ PY + ++ D Sbjct: 227 IYNQLGIKLVHNFKIKEIREHEIVDEKGNTIPADITIL---LPPYTGNPALKNSTPDLVD 283 Query: 324 KRGRLVIDDQFNS-KFPHIKVVGDVT--FGPMLAHKAEEEGIAAVEMLKTG---HGHVNY 377 G + D S K+ ++ VGD P L + A G A + L V+ Sbjct: 284 DGGFIPTDLNMVSIKYDNVYAVGDANSMTVPKLGYLAVMTGRIAAQHLANRLGVPTKVD- 342 Query: 378 NNIPSVM 384 P+++ Sbjct: 343 KYYPTIV 349 Score = 39.1 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 21/117 (17%), Positives = 44/117 (37%), Gaps = 22/117 (18%) Query: 206 RLTIIGGGIIGLEMGSVYSRL---GSKVTVV------EFQPQI------GASMDGEVAKA 250 ++ ++GG L RL + V V+ F+P + +D E+ Sbjct: 3 KVLVLGGRFGALTAAYTLKRLVGSKADVKVINKSRFSYFRPALPHVAIGVRDVD-ELKVD 61 Query: 251 TQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRR 307 + L ++G+ F+ T ++ D K+ +V E + ++V +G Sbjct: 62 LSEALPEKGIQFQEGT----VEKIDAKS--SMVYYTKPDGSMAEEEYDYVIVGIGAH 112 >2GAG-A nrPDB Length = 965 Score = 50.3 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 54/299 (18%), Positives = 100/299 (33%), Gaps = 55/299 (18%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQ 85 DV+++G GPAG AA +A++ G +++R + GGT L+ Sbjct: 128 HTDVLVVGAGPAGLAAAREASRSGARVMLLDERAEAGGTLLD----------TAGEQIDG 177 Query: 86 MHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDET 145 M + A + +L E + + + ++ Sbjct: 178 MDSSA--------------------WIEQVTSELAEAEETTHLQRTTVFGSYDANYLIAA 217 Query: 146 KIRVTPVDGLEGTVKEDHIL---DVKNIIVATGSEVTPF-------PGIEIDEEKIVSST 195 + R +DG G + K +++ATG+ P PGI + V S Sbjct: 218 QRRTVHLDGPSGPGVSRERIWHIRAKQVVLATGAHERPIVFENNDRPGIMLAGA--VRSY 275 Query: 196 GALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFL 255 R+ + E+ + G V V++ + A Sbjct: 276 LNRYGVRAGARIAVATTNDSAYELVRELAATGGVVAVIDARSS---------ISAAAAQA 326 Query: 256 KKQGLDFKLSTKVISAKRNDDKNVVEIVV----EDTKTNKQENLEAEVLLVAVGRRPYI 310 G+ + V+ + +++ + IVV E + + EA+VL VA G P + Sbjct: 327 VADGVQVISGSVVVDTEADENGELSAIVVAELDEARELGGTQRFEADVLAVAGGFNPVV 385 >3K30-A nrPDB Length = 690 Score = 49.9 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 50/356 (14%), Positives = 104/356 (29%), Gaps = 99/356 (27%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHT 88 V+++G GP+G AA G++ E LGG ++ Sbjct: 394 VLVVGAGPSGLEAARALGVRGYDVVLAEAGRDLGG---------------------RVTQ 432 Query: 89 EAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIR 148 E+ G+ ++ ++ + +L Sbjct: 433 ESALPGLSA-------WGRVKEYREAVLAEL---------------------------PN 458 Query: 149 VTPVDGLEGTVKEDHILDVKNIIVATGS----------EVTPFPGIEIDEEKIVSSTGAL 198 V T + +++I ATG+ T P E +++ Sbjct: 459 VEIYRESPMTGDDIVEFGFEHVITATGATWRTDGVARFHTTALPIAE--GMQVLGPDDLF 516 Query: 199 SLKEIPKRLTIIG-------GGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEV-AKA 250 + + + ++ GG++ + ++ G +V++V Q+ + + Sbjct: 517 AGRLPDGKKVVVYDDDHYYLGGVV----AELLAQKGYEVSIVTPGAQVSSWTNNTFEVNR 572 Query: 251 TQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYI 310 Q+ L + G+ + V DT + + LE + +++ R P Sbjct: 573 IQRRLIENGVARVTDH------AVVAVGAGGVTVRDTYASIERELECDAVVMVTARLPR- 625 Query: 311 AGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVE 366 L + + G + I GD +A A G A E Sbjct: 626 EELYLDL--VARRDAGEIA-------SVRGI---GDAWAPGTIA-AAVWSGRRAAE 668 Score = 42.2 bits (98), Expect = 6e-04, Method: Composition-based stats. Identities = 20/106 (18%), Positives = 35/106 (33%), Gaps = 6/106 (5%) Query: 201 KEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKA------TQKF 254 KE R+ ++G G GLE G V + E +G + E A K Sbjct: 388 KESDARVLVVGAGPSGLEAARALGVRGYDVVLAEAGRDLGGRVTQESALPGLSAWGRVKE 447 Query: 255 LKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVL 300 ++ L + ++ ++VE E T + + Sbjct: 448 YREAVLAELPNVEIYRESPMTGDDIVEFGFEHVITATGATWRTDGV 493 >1NAA-A nrPDB Length = 541 Score = 49.9 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 14/42 (33%), Positives = 24/42 (57%), Gaps = 4/42 (9%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRG----KLGGT 64 +D +I+G GP G +AA + ++ G +E+ G + GGT Sbjct: 3 YDYIIVGAGPGGIIAADRLSEAGKKVLLLERGGPSTKQTGGT 44 >5J7X-A nrPDB Length = 549 Score = 49.5 bits (117), Expect = 4e-06, Method: Composition-based stats. Identities = 42/244 (17%), Positives = 83/244 (34%), Gaps = 40/244 (16%) Query: 26 SHDVVIIGGGPAGYVAAIKAA-QLGFNTACVEKRGKLGGTCLN-------VGC-IPSKAL 76 D +IIG G +G K +L E +GGT N V C +P Sbjct: 12 HLDALIIGSGFSGIYLLHKLRDELKLKVKIFEAESDIGGTWNNNRYPGARVDCPVP---- 67 Query: 77 LNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYK 136 + + Q ++ N + D V ++ + ++V Sbjct: 68 ----FYAYSLPEVWQSWNW---TELYPNQKEIKSYFD-HVDRVLDVRKDCLFHSRVN--- 116 Query: 137 GNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATG----SEVTPFPGIEIDEEKIV 192 G+F++ T + + K ++VA G S + + G++ + I Sbjct: 117 -EGTFDEAT-------GRWTVWTTDGKVATAKYLLVAVGFASKSYLPDWKGLDSFKGTIY 168 Query: 193 SST---GALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQI-GASMDGEVA 248 S A + K++ +IG G G+++ ++R + + + P + E+ Sbjct: 169 HSAHWPEAEEISVKGKKVAVIGTGSTGIQIFQEWAREAEEAFLFQRTPNLCLPMRQQELH 228 Query: 249 KATQ 252 Q Sbjct: 229 AGYQ 232 Score = 32.6 bits (73), Expect = 0.45, Method: Composition-based stats. Identities = 13/73 (17%), Positives = 30/73 (41%), Gaps = 4/73 (5%) Query: 257 KQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAG---L 313 +Q + + + + +V + T ++ E +++ VA G G L Sbjct: 341 EQDFYEQFNKSNVHIVDTKSQPIVGVTPTGIVTADEKVHEVDIIAVATGFDAVTGGLLRL 400 Query: 314 GAEKI-GLEVDKR 325 G + + G+ +D+R Sbjct: 401 GLKDVNGVGLDER 413 >5BR7-A nrPDB Length = 393 Score = 49.2 bits (116), Expect = 4e-06, Method: Composition-based stats. Identities = 21/70 (30%), Positives = 32/70 (45%), Gaps = 3/70 (4%) Query: 27 HDVVIIGGGPAGYVAAIKAA-QLGFNTACVEKRGKLGGTCLNVGCIPSKALLN--NSHLF 83 D++++G G G A +AA QLG VEKR LGG + + ++ +HLF Sbjct: 4 FDLIVVGSGLFGLTVAERAASQLGKKVLIVEKRSHLGGNAYSEAEPETGIEIHKYGAHLF 63 Query: 84 HQMHTEAQKR 93 H + Sbjct: 64 HTSNKRVWDY 73 >3MJ4-A nrPDB Length = 397 Score = 49.2 bits (116), Expect = 5e-06, Method: Composition-based stats. Identities = 22/93 (23%), Positives = 41/93 (44%), Gaps = 9/93 (9%) Query: 6 SLLNNKRAFSSTVRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGT- 64 ++ N + ++T +K D +I+G G AG V A + A G V++R +GG Sbjct: 9 AVTNERTEQTNTTNEQQESKGFDYLIVGAGFAGSVLAERLASSGQRVLIVDRRPHIGGNA 68 Query: 65 --CLNVGCIPSKALLN--NSHLFHQMHTEAQKR 93 C + + L++ H+FH + + Sbjct: 69 YDCYDDAGV----LIHPYGPHIFHTNSKDVFEY 97 Score = 31.8 bits (71), Expect = 0.72, Method: Composition-based stats. Identities = 9/32 (28%), Positives = 16/32 (50%) Query: 208 TIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQI 239 I+G G G + + G +V +V+ +P I Sbjct: 33 LIVGAGFAGSVLAERLASSGQRVLIVDRRPHI 64 >6CR0-A nrPDB Length = 440 Score = 48.8 bits (115), Expect = 5e-06, Method: Composition-based stats. Identities = 21/90 (23%), Positives = 38/90 (42%), Gaps = 11/90 (12%) Query: 25 KSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGT--CLNVGCIP-----SKALL 77 K +D +++G G +G VAA + + G + +E R +LGG +N P + Sbjct: 7 KIYDAIVVGAGFSGLVAARELSAQGRSVLIIEARHRLGGRTHVVNFLGRPVEIGGAGVHW 66 Query: 78 NNSHLFHQMHTEAQKRGIDVNGDIKINVAN 107 H+F +M Q+ G ++ Sbjct: 67 CQPHVFAEM----QRYGFGFKEAPLADLDK 92 Score = 32.2 bits (72), Expect = 0.56, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 16/35 (45%) Query: 208 TIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGAS 242 ++G G GL S G V ++E + ++G Sbjct: 12 IVVGAGFSGLVAARELSAQGRSVLIIEARHRLGGR 46 >4RG3-A nrPDB Length = 548 Score = 48.4 bits (114), Expect = 7e-06, Method: Composition-based stats. Identities = 41/231 (17%), Positives = 74/231 (32%), Gaps = 32/231 (13%) Query: 21 LTINKSH--DVVIIGGGPAGYVAAIKA-AQLGFNTACVEKRGKLGGTCLNVGCIPSKALL 77 +T +H D V+IG G G A K +LG T +K GGT Sbjct: 9 MTAQTTHTVDAVVIGAGFGGIYAVHKLHHELGLTTVGFDKADGPGGT------------W 56 Query: 78 N---NSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTY 134 + + D + + + + ++ L ++ + Sbjct: 57 YWNRYPGALSDTESHLYRFSFDRDLLQESTWKTTYITQPEILEYLEDVVDRFDLRRHF-- 114 Query: 135 YKGNGSFEDETKIRVTPVDGLEGTVKEDH--ILDVKNIIVATG----SEVTPFPGIEIDE 188 F E + D V DH + K ++ A G PG++ E Sbjct: 115 -----KFGTEVTSALYLDDENLWEVTTDHGEVYRAKYVVNAVGLLSAINFPNLPGLDTFE 169 Query: 189 EKIVSSTGALSLKEIPK-RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQ 238 + + + K + R+ +IG G G ++ + + +TV PQ Sbjct: 170 GETIHTAAWPEGKSLAGRRVGVIGTGSTGQQVITSLAPEVEHLTVFVRTPQ 220 >1Y56-A nrPDB Length = 493 Score = 48.0 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 64/341 (18%), Positives = 109/341 (31%), Gaps = 88/341 (25%) Query: 47 QLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIKINVA 106 Q A +E+RG LGG + +GI G K + Sbjct: 128 QQYLTVALIEERGWLGG-------------------------DMWLKGIKQEGFNKDS-- 160 Query: 107 NFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILD 166 +K ++ V +L ++ + + + + F + V D L + Sbjct: 161 --RKVVEELVGKLNENTKIYLETSALGVFDKGEYFL----VPVVRGDKLIEIL------- 207 Query: 167 VKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYS-R 225 K +++ATG+ + ST ++P + LE+ +V+ Sbjct: 208 AKRVVLATGA---------------IDSTMLFENNDMPG----VFRRDFALEVMNVWEVA 248 Query: 226 LGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVE 285 G KV V G A + L++ G+D+ V + N+ VE Sbjct: 249 PGRKVAV-----------TGSKADEVIQELERWGIDYVHIPNVKRVEGNEK-------VE 290 Query: 286 DTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGR--LVIDDQFNSKFPHIKV 343 + + L+ A GRRP I + L +RG V+D+ K I V Sbjct: 291 RVIDMNNHEYKVDALIFADGRRPDINPITQAGGKLRF-RRGYYSPVLDEYHRIK-DGIYV 348 Query: 344 VGDVTFGPMLAHKAEE-EGIAAVEMLKTGHGHVNYNNIPSV 383 G H A EG + Y+ P + Sbjct: 349 AGSAVSIKP--HYANYLEGKLVGAYILKE---FGYDAQPCI 384 >6ER9-A nrPDB Length = 549 Score = 47.6 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 39/220 (17%), Positives = 76/220 (34%), Gaps = 26/220 (11%) Query: 28 DVVIIGGGPAGYVAAIKA-AQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQM 86 D V+IG G G A K + G +K GGT + + Sbjct: 11 DAVVIGAGFGGIYAVHKLHNEQGLTVVGFDKADGPGGT------------WYWNRYPGAL 58 Query: 87 H-TEAQKRGIDVNGDIKINVANFQKAKDDAVKQ--LTGGIELLFKKNKVTYYKGNGSFED 143 TE+ + D+ + K + Q + +E + + + + G+ Sbjct: 59 SDTESHLYRFSFDRDLLQD----GTWKTTYITQPEILEYLESVVDRFDLRRHFRFGTEVT 114 Query: 144 ETKIRVTPVDGLEGTVKEDHILDVKNIIVATG----SEVTPFPGIEIDEEKIVSSTGALS 199 I + + E + + + K ++ A G PG++ E + + + Sbjct: 115 S-AIYLEDENLWEVSTDKGEVYRAKYVVNAVGLLSAINFPDLPGLDTFEGETIHTAAWPE 173 Query: 200 LKEIP-KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQ 238 K + KR+ +IG G G ++ + + +TV PQ Sbjct: 174 GKNLAGKRVGVIGTGSTGQQVITALAPEVEHLTVFVRTPQ 213 >3RHA-A nrPDB Length = 482 Score = 47.6 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 16/36 (44%), Positives = 24/36 (66%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 DVVI+G GP+G AA + + G + A +E R ++GG Sbjct: 9 DVVIVGAGPSGLTAARELKKAGLSVAVLEARDRVGG 44 Score = 39.5 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 10/40 (25%), Positives = 19/40 (47%) Query: 203 IPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGAS 242 + + + I+G G GL + G V V+E + ++G Sbjct: 6 LDRDVVIVGAGPSGLTAARELKKAGLSVAVLEARDRVGGR 45 >1I8T-A nrPDB Length = 367 Score = 47.2 bits (111), Expect = 1e-05, Method: Composition-based stats. Identities = 20/89 (22%), Positives = 33/89 (37%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQ 85 +D +I+G G G V A + +L +EKR +GG C + +H+FH Sbjct: 1 MYDYIIVGSGLFGAVCANELKKLNKKVLVIEKRNHIGGNAYTEDCEGIQIHKYGAHIFHT 60 Query: 86 MHTEAQKRGIDVNGDIKINVANFQKAKDD 114 D+ + + KD Sbjct: 61 NDKYIWDYVNDLVEFNRFTNSPLAIYKDK 89 Score = 30.3 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 10/32 (31%), Positives = 16/32 (50%) Query: 208 TIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQI 239 I+G G+ G + +L KV V+E + I Sbjct: 5 IIVGSGLFGAVCANELKKLNKKVLVIEKRNHI 36 >2BXR-A nrPDB Length = 527 Score = 47.2 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 15/38 (39%), Positives = 22/38 (57%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 DVV+IGGG +G AA + G + +E R ++GG Sbjct: 13 MFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGG 50 Score = 40.3 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 12/36 (33%), Positives = 20/36 (55%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGAS 242 + +IGGGI GL + + G V V+E + ++G Sbjct: 16 VVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGR 51 >4AP1-A nrPDB Length = 549 Score = 47.2 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 41/238 (17%), Positives = 83/238 (34%), Gaps = 34/238 (14%) Query: 12 RAFSSTVRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCI 71 R+ + T S+DVV++G G AG A + G E +GG Sbjct: 7 RSVVTAPDATTGTTSYDVVVVGAGIAGLYAIHRFRSQGLTVRAFEAASGVGG-------- 58 Query: 72 PSKALLNNSHLFHQMHTEAQKRGIDVNGDIKI--NVANFQKAKDDAVKQLTGGIELLFKK 129 N + + E+ + +++ N + + + + L + + Sbjct: 59 ---VWYWNRYPGARCDVESIDYSYSFSPELEQEWNWSEKYATQPEILAYLEHVADRFDLR 115 Query: 130 NKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDH--ILDVKNIIVATG----SEVTPFPG 183 + F+ V +GL TV+ D + + ++VA G + F G Sbjct: 116 RDI-------RFDTRVTSAVLDEEGLRWTVRTDRGDEVSARFLVVAAGPLSNANTPAFDG 168 Query: 184 IEIDEEKIVSS-----TGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQ 236 ++ IV + G + KR+ +IG G G++ + + ++ V + Sbjct: 169 LDRFTGDIVHTARWPHDG---VDFTGKRVGVIGTGSSGIQSIPIIAEQAEQLFVFQRS 223 >2JB2-A nrPDB Length = 489 Score = 46.5 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 16/38 (42%), Positives = 24/38 (63%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 SH VV++GGGPAG +A + + G+ +E R + GG Sbjct: 11 SHSVVVLGGGPAGLCSAFELQKAGYKVTVLEARTRPGG 48 Score = 33.4 bits (75), Expect = 0.22, Method: Composition-based stats. Identities = 12/38 (31%), Positives = 20/38 (52%) Query: 206 RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASM 243 + ++GGG GL + G KVTV+E + + G + Sbjct: 13 SVVVLGGGPAGLCSAFELQKAGYKVTVLEARTRPGGRV 50 >1O5W-A nrPDB Length = 534 Score = 46.1 bits (108), Expect = 3e-05, Method: Composition-based stats. Identities = 15/38 (39%), Positives = 22/38 (57%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 DVV+IGGG +G AA ++ N +E R ++GG Sbjct: 21 MFDVVVIGGGISGLAAAKLLSEYKINVLVLEARDRVGG 58 Score = 36.4 bits (83), Expect = 0.026, Method: Composition-based stats. Identities = 12/36 (33%), Positives = 19/36 (52%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGAS 242 + +IGGGI GL + S V V+E + ++G Sbjct: 24 VVVIGGGISGLAAAKLLSEYKINVLVLEARDRVGGR 59 >3T14-A nrPDB Length = 437 Score = 46.1 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 60/341 (17%), Positives = 115/341 (33%), Gaps = 88/341 (25%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLG-GTCLNVGCIPSKALLNNSHLFHQMH 87 VVI+G G G AA E + LG G + L++ + F + Sbjct: 7 VVILGAGTGGMPAAY------------EMKEALGSGHEV--------TLISANDYFQFVP 46 Query: 88 TEAQ-KRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETK 146 + G DI + ++ + K + + + D Sbjct: 47 SNPWVGVGWKERDDIAFPIRHYVERK------------------GIHFIAQSAEQIDAEA 88 Query: 147 IRVTPVDGLEGTVKEDHILDVKNIIVATGSEV--TPFPGI---EIDEEKIVSST------ 195 +T DG + + +++ATG ++ PG E + I + Sbjct: 89 QNITLADG--------NTVHYDYLMIATGPKLAFENVPGSDPHEGPVQSIATVDHAERAF 140 Query: 196 -GALSLKEIPKRLTIIG--GGII--------GLEMGSVYSRLGSK--------VTVVEFQ 236 +L P + +IG G + + S + G + +T + Sbjct: 141 AEYQALLREPGPI-VIGAMAGASCFGPAYEYAMIVASDLKKRGMRDKIPSFTFITSEPYI 199 Query: 237 PQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLE 296 +G G+ K LK++G++ + KV + D+K V V E +T K+ L Sbjct: 200 GHLGIQGVGDSKGILTKGLKEEGIEAYTNCKVTKVE--DNKMYVTQVDEKGETIKEMVLP 257 Query: 297 AEVLLVAVGRRPYIAGLGAEKIGLE--VDKRGRLVIDDQFN 335 + ++ P G+ A G+E + G +++D+ Sbjct: 258 VKFGMM----IPAFKGVPA-VAGVEGLCNPGGFVLVDEHQR 293 >5EQD-A nrPDB Length = 400 Score = 46.1 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 20/77 (25%), Positives = 30/77 (38%), Gaps = 9/77 (11%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAA-QLGFNTACVEKRGKLGGTCLNVGCIPSK-----AL 76 + D+ ++G G G A +AA QLG +E+R +GG N P Sbjct: 1 STGNFDLFVVGSGFFGLTIAERAATQLGKRVLVIERRPHIGG---NAYSEPEPETGIEVH 57 Query: 77 LNNSHLFHQMHTEAQKR 93 +HLFH + Sbjct: 58 KYGAHLFHTSNKRVWDY 74 Score = 33.4 bits (75), Expect = 0.24, Method: Composition-based stats. Identities = 17/54 (31%), Positives = 26/54 (48%), Gaps = 8/54 (14%) Query: 194 STGALSLKEIPKRLTIIGGGIIGLEMGS-VYSRLGSKVTVVEFQPQIGASMDGE 246 STG L ++G G GL + ++LG +V V+E +P IG + E Sbjct: 1 STGNFDLF-------VVGSGFFGLTIAERAATQLGKRVLVIERRPHIGGNAYSE 47 >3KVE-A nrPDB Length = 486 Score = 45.7 bits (107), Expect = 4e-05, Method: Composition-based stats. Identities = 13/35 (37%), Positives = 20/35 (57%) Query: 204 PKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQ 238 PK + ++G G+ GL V + G KVTV+E + Sbjct: 33 PKHVVVVGAGMSGLSAAYVLAGAGHKVTVLEASER 67 Score = 41.8 bits (97), Expect = 8e-04, Method: Composition-based stats. Identities = 47/302 (15%), Positives = 91/302 (30%), Gaps = 56/302 (18%) Query: 22 TINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG---TCLNVGCIPSKALLN 78 T N H VV++G G +G AA A G +E + GG T N SK Sbjct: 30 TSNPKH-VVVVGAGMSGLSAAYVLAGAGHKVTVLEASERAGGRVRTHRN-----SKEGWY 83 Query: 79 N-------SHLFHQMHTEAQKRGIDVNGDIKIN-----VANFQKAKDDAVKQLTGGIELL 126 + +K G+++N + N + + V + G ++ Sbjct: 84 ANLGPMRIPEKHRIVREYIRKFGLNLNEFSQENDNAWYFIKNIRKRVGEVNKDPGLLKYP 143 Query: 127 FKKNKVTYYKGNGSFED-ETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIE 185 K ++ G E + ++ + + K ++ G+ PG Sbjct: 144 VKPSEEGKSAGQLYEESLGSAVKDLKRTNCSYILNKYDTYSTKEYLIKEGNLS---PGAV 200 Query: 186 IDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVE---FQPQIGAS 242 +++ G S L + +I Sbjct: 201 DMIGDLLNED----------------SGY----YVSFIESLKHD-DIFAYEKRFDEIVGG 239 Query: 243 MDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLV 302 MD + +K K + +VI ++N ++ V + T+ A+ ++V Sbjct: 240 MDQLPTSMYRAIEEK----VKFNARVIKIQQNANQVTVTYQTPEKDTSSN---TADYVIV 292 Query: 303 AV 304 Sbjct: 293 CT 294 >2VOU-A nrPDB Length = 397 Score = 45.7 bits (107), Expect = 5e-05, Method: Composition-based stats. Identities = 19/80 (23%), Positives = 31/80 (38%), Gaps = 2/80 (2%) Query: 206 RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAK--ATQKFLKKQGLDFK 263 R+ ++GG I GL + G V V E PQ + + +L +QG++ Sbjct: 7 RIAVVGGSISGLTAALMLRDAGVDVDVYERSPQPLSGFGTGIVVQPELVHYLLEQGVELD 66 Query: 264 LSTKVISAKRNDDKNVVEIV 283 + S+ D E V Sbjct: 67 SISVPSSSMEYVDALTGERV 86 >3BHF-A nrPDB Length = 390 Score = 45.3 bits (106), Expect = 6e-05, Method: Composition-based stats. Identities = 10/37 (27%), Positives = 18/37 (48%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRG 59 ++ DV+++G G G A + A+ G T V+ Sbjct: 1 MSTHFDVIVVGAGSMGMAAGYQLAKQGVKTLLVDAFD 37 >1REO-A nrPDB Length = 486 Score = 44.9 bits (105), Expect = 8e-05, Method: Composition-based stats. Identities = 13/35 (37%), Positives = 20/35 (57%) Query: 204 PKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQ 238 PK + ++G G+ GL V S G +VTV+E + Sbjct: 33 PKHVVVVGAGMSGLSAAYVLSGAGHQVTVLEASER 67 Score = 38.4 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 47/302 (15%), Positives = 91/302 (30%), Gaps = 56/302 (18%) Query: 22 TINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG---TCLNVGCIPSKALLN 78 T N H VV++G G +G AA + G +E + GG T N K Sbjct: 30 TSNPKH-VVVVGAGMSGLSAAYVLSGAGHQVTVLEASERAGGRVRTYRND-----KEDWY 83 Query: 79 N-------SHLFHQMHTEAQKRGIDVNGDIKIN-----VANFQKAKDDAVKQLTGGIELL 126 + +K G+ +N + N + + VK+ G ++ Sbjct: 84 ANLGPMRLPEKHRIVREYIRKFGLQLNEFSQENDNAWYFIKNIRKRVGEVKKDPGVLKYP 143 Query: 127 FKKNKVTYYKGNGSFED-ETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIE 185 K ++ G E + + + K ++ G+ PG Sbjct: 144 VKPSEEGKSAGQLYEESLGKVVEELKRTNCSYILNKYDTYSTKEYLLKEGNLS---PGAV 200 Query: 186 IDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVE---FQPQIGAS 242 +++ + P+ L + +I Sbjct: 201 DMIGDLMNEDSGYYVS-FPESL--------------------RHDDIFAYEKRFDEIVGG 239 Query: 243 MDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLV 302 MD + +K L+ +VI ++N +K V V T + ++ A+ ++V Sbjct: 240 MDKLPTSMYRAIEEK----VHLNAQVIKIQKNAEKVTV---VYQTPAKEMASVTADYVIV 292 Query: 303 AV 304 Sbjct: 293 CT 294 >2VVL-G nrPDB Length = 495 Score = 44.9 bits (105), Expect = 8e-05, Method: Composition-based stats. Identities = 22/103 (21%), Positives = 34/103 (33%), Gaps = 11/103 (10%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGT--CLNVGCIP-----SKALLNNS 80 DV++IGGG G A GF T +E R ++GG N+ P + + S Sbjct: 41 DVIVIGGGYCGLTATRDLTVAGFKTLLLEARDRIGGRSWSSNIDGYPYEMGGTWVHWHQS 100 Query: 81 HLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGI 123 H + E + + N + T Sbjct: 101 H----VWREITRYKMHNALSPSFNFSRGVNHFQLRTNPTTSTY 139 Score = 37.2 bits (85), Expect = 0.015, Method: Composition-based stats. Identities = 17/66 (25%), Positives = 28/66 (42%), Gaps = 8/66 (12%) Query: 185 EIDEEKIVSSTGALSLK--------EIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQ 236 E + V+S G +S + P + +IGGG GL + G K ++E + Sbjct: 12 ETGLTQGVTSLGVISPPTNIEDTDKDGPWDVIVIGGGYCGLTATRDLTVAGFKTLLLEAR 71 Query: 237 PQIGAS 242 +IG Sbjct: 72 DRIGGR 77 >1VRQ-A nrPDB Length = 964 Score = 44.5 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 55/300 (18%), Positives = 105/300 (35%), Gaps = 57/300 (19%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQ 85 DV+++G GPAG AA +A++ G +++R + GGT L Sbjct: 127 HTDVLVVGAGPAGLAAAREASRSGARVMLLDERPEAGGT-----------------LREA 169 Query: 86 MHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDET 145 + GID + D ++L E + + + ++ Sbjct: 170 SGEQID--GIDAA-----------QWIDAVTEELAAAEETTHLQRTTVFGSYDANYILAA 216 Query: 146 KIRVTPVDGLEGTVKEDHI---LDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKE 202 + R +DG G + K +++AT + P D I+ A S++ Sbjct: 217 QRRTVHLDGPSGQGVSRERIWHIRAKQVVLATAAHERPIVFENNDRPGIML---AGSVRS 273 Query: 203 IPKRLTIIGGGIIGLE--------MGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKF 254 R + G I + + S + G V V++ + I A+ V Sbjct: 274 YLNRFGVRAGSKIAVATTNDSVYPLVSELAASGGVVAVIDARQNISAAAAQAVTD----- 328 Query: 255 LKKQGLDFKLSTKVISAKRNDDKNVVEIVV----EDTKTNKQENLEAEVLLVAVGRRPYI 310 G+ + V + + + + ++V E + + EA+VL V+ G P + Sbjct: 329 ----GVTVLTGSVVANTEADASGELSAVLVATLDEQRNLGEAQRFEADVLAVSGGFNPVV 384 >5KOX-A nrPDB Length = 476 Score = 44.5 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 26/166 (15%), Positives = 49/166 (29%), Gaps = 4/166 (2%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGC-IPSKALLNNSHLFHQM 86 DV+I GGGP G + A + G T +EK + G S +++ L + Sbjct: 6 DVIIAGGGPTGLMLAGELRLHGVRTVVLEKEPTPNQHSRSRGLHARSIEVMDQRGLLERF 65 Query: 87 HTEAQKRGI-DVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDET 145 ++ + + V + + T E Sbjct: 66 LAHGEQFRVGGFFAGLAAEWPADLDTAHSYVLAIPQVVTERLLTEHATELGAEIRRGCEV 125 Query: 146 KIRVTPVDGLEGTVKEDHILDVKNIIVATGSE--VTPFPGIEIDEE 189 DG+ + + L + ++ G V G++ E Sbjct: 126 AGLDQDADGVTAELADGTRLRARYLVGCDGGRSTVRRLLGVDFPGE 171 >4C3X-A nrPDB Length = 530 Score = 44.2 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 15/42 (35%), Positives = 20/42 (47%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVG 69 DV+++G G A AA G T +EK + GGT G Sbjct: 29 DVLVVGSGGGALTGAYTAAAQGLTTIVLEKTDRFGGTSAYSG 70 >1ZOV-A nrPDB Length = 386 Score = 44.2 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 10/36 (27%), Positives = 16/36 (44%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRG 59 + DV+++G G G A A+ G T V+ Sbjct: 1 STHFDVIVVGAGSMGMAAGYYLAKQGVKTLLVDSFD 36 Score = 28.4 bits (62), Expect = 8.2, Method: Composition-based stats. Identities = 7/33 (21%), Positives = 16/33 (48%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQI 239 + ++G G +G+ G ++ G K +V+ Sbjct: 6 VIVVGAGSMGMAAGYYLAKQGVKTLLVDSFDPP 38 >1F8S-A nrPDB Length = 498 Score = 44.2 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 50/306 (16%), Positives = 88/306 (28%), Gaps = 64/306 (20%) Query: 22 TINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTC-----------LNVGC 70 T N H VVI+G G AG AA A G +E + GG N+G Sbjct: 30 TSNPKH-VVIVGAGMAGLSAAYVLAGAGHQVTVLEASERPGGRVRTYRNEEAGWYANLGP 88 Query: 71 I--PSKALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFK 128 + P K + + + + + + K VK+ G ++ K Sbjct: 89 MRLPEKHRI-VREYIRKFDLRLNEFSQENDNAWYF--IKNIRKKVGEVKKDPGLLKYPVK 145 Query: 129 KNKVTYYKGNGSFED-ETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEID 187 ++ G E + + + K ++ G Sbjct: 146 PSEAGKSAGQLYEESLGKVVEELKRTNCSYILNKYDTYSTKEYLIKEG------------ 193 Query: 188 EEKIVSSTGALSLKEIPKRLTIIG------GGIIGLEMGSVYSRLGSKVTVVE---FQPQ 238 P + +IG G S L + + Sbjct: 194 -------------DLSPGAVDMIGDLLNEDSGY----YVSFIESLKHD-DIFAYEKRFDE 235 Query: 239 IGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAE 298 I MD + K + +VI ++ND K V V +T + + ++ A+ Sbjct: 236 IVDGMDKLPTAMYRDIQDK----VHFNAQVIKIQQNDQKVTV---VYETLSKETPSVTAD 288 Query: 299 VLLVAV 304 ++V Sbjct: 289 YVIVCT 294 >6BRD-A nrPDB Length = 476 Score = 43.8 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 24/168 (14%), Positives = 46/168 (27%), Gaps = 4/168 (2%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGC-IPSKALLNNSHLFH 84 DV+++GGGP G + A + G +EK + G + S ++ L Sbjct: 1 MFDVIVVGGGPTGLMLAGELRLHGVRVLVLEKETEPTRQSRAQGLHVRSIEVMAQRGLLE 60 Query: 85 QMHTEAQKRGI-DVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFED 143 + + + + V + I T Sbjct: 61 RFLERGHTVAVGGFFAGLATSWPERLDTAHSYVLAVPQVITEQLLAEHATALGAEIRRGR 120 Query: 144 ETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSE--VTPFPGIEIDEE 189 DG+ + + L + ++ G V G+ E Sbjct: 121 ALVGLRQDEDGVTVDLADGEQLRARYVVGCDGGRSTVRKLLGVAFPGE 168 Score = 31.4 bits (70), Expect = 0.95, Method: Composition-based stats. Identities = 9/36 (25%), Positives = 17/36 (47%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGAS 242 + ++GGG GL + G +V V+E + + Sbjct: 4 VIVVGGGPTGLMLAGELRLHGVRVLVLEKETEPTRQ 39 >2GMH-A nrPDB Length = 584 Score = 43.4 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 25/96 (26%), Positives = 38/96 (39%), Gaps = 23/96 (23%) Query: 28 DVVIIGGGPAGYVAAIK----AAQLG--FNTACVEKRGKLG-----GTCLNVGCIPSKAL 76 DVVI+G GPAG AA + AAQ VEK +G G CL+ Sbjct: 37 DVVIVGAGPAGLSAATRLKQLAAQHEKDLRVCLVEKAAHIGAHTLSGACLD--------- 87 Query: 77 LNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAK 112 F ++ + +++G +N + + K Sbjct: 88 ---PRAFEELFPDWKEKGAPLNTPVTEDRFGILTEK 120 >3ABT-A nrPDB Length = 662 Score = 43.0 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 11/39 (28%), Positives = 20/39 (51%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASM 243 ++ IIG G+ GL G VT++E + ++G + Sbjct: 108 GKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRV 146 Score = 43.0 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 15/46 (32%), Positives = 25/46 (54%) Query: 18 VRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 ++ L K+ V+IIG G +G AA + G + +E R ++GG Sbjct: 99 IKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGG 144 >3ATQ-A nrPDB Length = 453 Score = 43.0 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 13/34 (38%), Positives = 20/34 (58%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRG 59 +DV+IIGGG AG AA + ++ G V+ + Sbjct: 6 KYDVLIIGGGFAGSSAAYQLSRRGLKILLVDSKP 39 Score = 31.4 bits (70), Expect = 0.85, Method: Composition-based stats. Identities = 19/68 (27%), Positives = 28/68 (41%), Gaps = 2/68 (2%) Query: 201 KEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQK-FLKKQG 259 KE+ + IIGGG G SR G K+ +V+ +P D A K K G Sbjct: 3 KELKYDVLIIGGGFAGSSAAYQLSRRGLKILLVDSKPW-NRIGDKPCGDAVSKAHFDKLG 61 Query: 260 LDFKLSTK 267 + + + Sbjct: 62 MPYPKGEE 69 >6HNS-A nrPDB Length = 454 Score = 43.0 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 39/236 (16%), Positives = 69/236 (29%), Gaps = 53/236 (22%) Query: 29 VVIIGGGPAGYV---AAIKAAQLGF---NTACVEKRGKLGGTCLNVGCIPSKALLNNS-- 80 V IIG GP G A AA G C EK+ GG + N + Sbjct: 5 VAIIGAGPCGLAQLRAFQSAAAKGAAIPELVCFEKQSDWGG------------MWNYTWR 52 Query: 81 ----HLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYK 136 +H + + A++ D+ + G +V + Sbjct: 53 TGVDEHGEPVHGSMYRYLWSNGPKECLEFADYT--FDEHFGRPIGSYP----PREVLWDY 106 Query: 137 GNGSFEDET------------KIRVTPVDGLEGTVKEDH------ILDVKNIIVATGS-- 176 G E ++ GL +DH ++ A G Sbjct: 107 IKGRVEKAGVRDYIRFNTAVRQVSYDETSGLFSVTVQDHSNNRVYTETFDYVVNACGHFS 166 Query: 177 --EVTPFPGIEIDEEKIVSSTGALS-LKEIPKRLTIIGGGIIGLEMGSVYSRLGSK 229 F G E +++ + L+ K + ++G ++GS + G++ Sbjct: 167 TPNTPYFEGFERFGGRVLHAHDFRDALEFKDKDILVVGSSYSAEDIGSQCYKYGAR 222 >5L3D-A nrPDB Length = 852 Score = 43.0 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 11/39 (28%), Positives = 20/39 (51%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASM 243 ++ IIG G+ GL G VT++E + ++G + Sbjct: 279 GKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRV 317 Score = 42.6 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 15/46 (32%), Positives = 25/46 (54%) Query: 18 VRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 ++ L K+ V+IIG G +G AA + G + +E R ++GG Sbjct: 270 IKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGG 315 >4MO2-B nrPDB Length = 368 Score = 42.6 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 18/70 (25%), Positives = 30/70 (42%), Gaps = 4/70 (5%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCL--NVGCIPSKALLNNSHLF 83 +D +I+G G G + A +A + G+ VE+R +GG C N+ I +H+F Sbjct: 1 MYDYLIVGSGLFGSIFAYEATEKGYTCLVVEQREHIGGNCYTENIKNI--NVHKYGAHIF 58 Query: 84 HQMHTEAQKR 93 Sbjct: 59 RTSDQNIWDY 68 >4Y4M-A nrPDB Length = 290 Score = 42.6 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 13/31 (41%), Positives = 18/31 (58%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKR 58 DVVI+G GP+G A A+ GF +E+ Sbjct: 61 DVVIVGAGPSGLTCARYLAKEGFKVVVLERH 91 Score = 35.7 bits (81), Expect = 0.046, Method: Composition-based stats. Identities = 10/30 (33%), Positives = 15/30 (50%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQ 236 + I+G G GL ++ G KV V+E Sbjct: 62 VVIVGAGPSGLTCARYLAKEGFKVVVLERH 91 >2UZZ-A nrPDB Length = 372 Score = 42.2 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 10/33 (30%), Positives = 15/33 (45%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKR 58 +D++IIG G G A A + G N + Sbjct: 2 KYDLIIIGSGSVGAAAGYYATRAGLNVLMTDAH 34 >3CP8-A nrPDB Length = 641 Score = 42.2 bits (98), Expect = 6e-04, Method: Composition-based stats. Identities = 26/157 (16%), Positives = 57/157 (36%), Gaps = 9/157 (5%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLF 83 + +DV+++G G AG AA+ A+ G + + + C P+ + + Sbjct: 19 SHMYDVIVVGAGHAGCEAALAVARGGLHCLLITSDLS---AVARMSCNPAIGGVAKGQIT 75 Query: 84 HQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGG---IELLFKKNKVTYYKGNGS 140 ++ + G ++ I ++K A+ + ++ ++ N Sbjct: 76 REIDALGGEMGKAIDAT-GIQFRMLNRSKGPAMHSPRAQADKTQYSLYMRRIVEHEPNID 134 Query: 141 FEDETKIRVTPVDGLEGTVK--EDHILDVKNIIVATG 175 +T I V+ G +V + K I+A G Sbjct: 135 LLQDTVIGVSANSGKFSSVTVRSGRAIQAKAAILACG 171 >3NK2-X nrPDB Length = 431 Score = 41.8 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 12/38 (31%), Positives = 19/38 (50%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 +D +++GGG +G AA G +E +LGG Sbjct: 1 MYDAIVVGGGFSGLKAARDLTNAGKKVLLLEGGERLGG 38 Score = 34.1 bits (77), Expect = 0.13, Method: Composition-based stats. Identities = 10/36 (27%), Positives = 18/36 (50%) Query: 208 TIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASM 243 ++GGG GL+ + G KV ++E ++G Sbjct: 5 IVVGGGFSGLKAARDLTNAGKKVLLLEGGERLGGRA 40 >4A6N-B nrPDB Length = 398 Score = 41.8 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 28/122 (22%), Positives = 47/122 (38%), Gaps = 25/122 (20%) Query: 204 PKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEF-QPQIGASMDGEV---AKATQKFLKK-- 257 K + IIGGG +GL M + + G V+V E + G + + Q+ +KK Sbjct: 26 DKNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARIFGGTLDLHKGSGQEAMKKAG 85 Query: 258 -----------QGLDF------KLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVL 300 G++ LSTK + + D EI D + +LE + + Sbjct: 86 LLQTYYDLALPMGVNIADEKGNILSTKNVKPENRFDNP--EINRNDLRAILLNSLENDTV 143 Query: 301 LV 302 + Sbjct: 144 IW 145 Score = 34.9 bits (79), Expect = 0.081, Method: Composition-based stats. Identities = 29/155 (18%), Positives = 54/155 (34%), Gaps = 10/155 (6%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRG-----KLGGTC-LNVGCIPSKALLNNSHL 82 V IIGGGP G A Q G + + E+ GGT L+ G + + + L Sbjct: 29 VAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARIFGGTLDLHKGS--GQEAMKKAGL 86 Query: 83 FHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFE 142 + A G+++ + K N+ + + K + + + + + Sbjct: 87 LQTYYDLALPMGVNIADE-KGNILSTKNVKPENRFDNPEINRNDLRAILLNSLENDTVIW 145 Query: 143 DETKIRVTPVDGLEGTVKEDH-ILDVKNIIVATGS 176 D + + P E+ +I+A G Sbjct: 146 DRKLVMLEPGKKKWTLTFENKPSETADLVILANGG 180 >3NIX-A nrPDB Length = 421 Score = 41.8 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 16/34 (47%), Positives = 20/34 (58%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKL 61 DV++IG GPAG VAA + GF VEK+ Sbjct: 7 DVLVIGAGPAGTVAASLVNKSGFKVKIVEKQKFP 40 Score = 31.1 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 20/82 (24%), Positives = 30/82 (36%), Gaps = 15/82 (18%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQ------------PQIGASMDGEVAKATQKF 254 + +IG G G S+ ++ G KV +VE Q P+ +D Sbjct: 8 VLVIGAGPAGTVAASLVNKSGFKVKIVEKQKFPRFVIGESLLPRCMEHLDE---AGFLDA 64 Query: 255 LKKQGLDFKLSTKVISAKRNDD 276 +K QG K K + K D Sbjct: 65 VKAQGFQQKFGAKFVRGKEIAD 86 >4DGK-A nrPDB Length = 501 Score = 41.8 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 12/34 (35%), Positives = 16/34 (47%) Query: 30 VIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 +IG G G AI+ G +E+R K GG Sbjct: 5 TVIGAGFGGLALAIRLQAAGIPVLLLEQRDKPGG 38 Score = 34.1 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 16/66 (24%), Positives = 24/66 (36%), Gaps = 9/66 (13%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKL 264 K T+IG G GL + G V ++E + + G + QG F Sbjct: 2 KPTTVIGAGFGGLALAIRLQAAGIPVLLLEQRDKPGGR---------AYVYEDQGFTFDA 52 Query: 265 STKVIS 270 VI+ Sbjct: 53 GPTVIT 58 >3HYW-A nrPDB Length = 430 Score = 41.8 bits (97), Expect = 8e-04, Method: Composition-based stats. Identities = 43/264 (16%), Positives = 85/264 (32%), Gaps = 45/264 (17%) Query: 126 LFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIE 185 L K + + D VT G + ++ +++ATG G E Sbjct: 65 LLPKFNIEFINEKAESIDPDANTVTTQSGKK--------IEYDYLVIATG--PKLVFGAE 114 Query: 186 IDEEKIVSSTGALSLKEIPKRL---------TIIGG--GII----GLEMGSVYS------ 224 EE S A E K+L +IG G+ E + Sbjct: 115 GQEENSTSICTAEHALETQKKLQELYANPGPVVIGAIPGVSCFGPAYEFALMLHYELKKR 174 Query: 225 --RLGSKVTVVEFQP---QIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNV 279 R +T + +P G G + + ++ +D+ + V + + + Sbjct: 175 GIRYKVPMTFITSEPYLGHFGVGGIGASKRLVEDLFAERNIDWIANVAVKAIEPD----- 229 Query: 280 VEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDD-QFNSKF 338 +++ ED N E + + + P + +K + ++++ N + Sbjct: 230 -KVIYEDLNGNTHEVPAKFTMFMPSFQGPEVVASAGDK--VANPANKMVIVNRCFQNPTY 286 Query: 339 PHIKVVGDVTFGPMLAHKAEEEGI 362 +I VG VT P + G+ Sbjct: 287 KNIFGVGVVTAIPPIEKTPIPTGV 310 >1SEZ-A nrPDB Length = 504 Score = 41.5 bits (96), Expect = 9e-04, Method: Composition-based stats. Identities = 16/40 (40%), Positives = 19/40 (47%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNV 68 V +IG G +G AA K G N E GK GG +V Sbjct: 16 VAVIGAGVSGLAAAYKLKIHGLNVTVFEAEGKAGGKLRSV 55 Score = 38.0 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 12/34 (35%), Positives = 17/34 (50%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQ 238 KR+ +IG G+ GL G VTV E + + Sbjct: 14 KRVAVIGAGVSGLAAAYKLKIHGLNVTVFEAEGK 47 >4Y4N-A nrPDB Length = 286 Score = 41.1 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 13/31 (41%), Positives = 19/31 (61%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKR 58 DV I+GGGP+G AA A+ G+ +E+ Sbjct: 54 DVAIVGGGPSGLTAARYIAKEGYKVVVLERH 84 Score = 33.8 bits (76), Expect = 0.19, Method: Composition-based stats. Identities = 15/46 (32%), Positives = 22/46 (47%) Query: 191 IVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQ 236 I+ S + L I + I+GGG GL ++ G KV V+E Sbjct: 39 ILKSAFDMWLDIIDVDVAIVGGGPSGLTAARYIAKEGYKVVVLERH 84 >4TLZ-A nrPDB Length = 443 Score = 41.1 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 24/112 (21%), Positives = 43/112 (38%), Gaps = 13/112 (11%) Query: 129 KNKVTYYK-GNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEID 187 ++VT + G G D + V T + ++ +NI+++TG G++ D Sbjct: 144 DSEVTAIRPGPGRPVDSVLVDV-------STPEATRTVEARNIVISTGLVPRMPAGVQSD 196 Query: 188 EEKIVSSTGALSLKEIP----KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEF 235 E SS ++ +R+ + GGG E+ TVV Sbjct: 197 EFVWHSSRFLDHFRDRDPRSLRRVAVAGGGQSAAEIVRFLHDNRPD-TVVHA 247 Score = 30.7 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 25/102 (24%), Positives = 36/102 (35%), Gaps = 11/102 (10%) Query: 236 QPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENL 295 + D EVA L+F V+ AKR D + V + +L Sbjct: 304 RDLYRRGYDDEVAG-------APRLNFVNLAHVVGAKRIADD--TRVTVYSMAREESYDL 354 Query: 296 EAEVLLVAVGRRP-YIAGLGAEKIGLEV-DKRGRLVIDDQFN 335 + +VL+ A G P L E V D GR +D + Sbjct: 355 DVDVLVCATGYDPMDPGDLLGELAEHCVQDAEGRWQVDRDYR 396 >4RPJ-A nrPDB Length = 399 Score = 40.7 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 12/42 (28%), Positives = 20/42 (47%), Gaps = 1/42 (2%) Query: 23 INKSHDVVIIGGGPAGYVAAIK-AAQLGFNTACVEKRGKLGG 63 + D+ ++G G G A + A QL +E+R +GG Sbjct: 4 MTARFDLFVVGSGFFGLTIAERVATQLDKRVLVLERRPHIGG 45 >3UKH-A nrPDB Length = 519 Score = 40.7 bits (94), Expect = 0.001, Method: Composition-based stats. Identities = 14/37 (37%), Positives = 20/37 (54%), Gaps = 1/37 (2%) Query: 28 DVVIIGGGPAGYVAAIKAAQL-GFNTACVEKRGKLGG 63 DV++IG GP G AA + Q+ G + V+ GG Sbjct: 8 DVLVIGAGPTGLGAAKRLNQIDGPSWMIVDSNETPGG 44 >5MOG-A nrPDB Length = 497 Score = 40.7 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 16/41 (39%), Positives = 17/41 (41%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 K VVI G G AG A A G +E R LGG Sbjct: 14 PTKPLQVVIAGAGLAGLSTAKYLADAGHKPILLEARDVLGG 54 Score = 29.5 bits (65), Expect = 3.0, Method: Composition-based stats. Identities = 9/39 (23%), Positives = 17/39 (43%) Query: 201 KEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQI 239 P ++ I G G+ GL + G K ++E + + Sbjct: 14 PTKPLQVVIAGAGLAGLSTAKYLADAGHKPILLEARDVL 52 >3IHG-A nrPDB Length = 535 Score = 40.3 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 12/34 (35%), Positives = 18/34 (52%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKL 61 DV+++G G G A+ A+ G VE+R L Sbjct: 7 DVLVVGAGLGGLSTAMFLARQGVRVLVVERRPGL 40 Score = 36.1 bits (82), Expect = 0.033, Method: Composition-based stats. Identities = 11/36 (30%), Positives = 19/36 (52%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGAS 242 + ++G G+ GL +R G +V VVE +P + Sbjct: 8 VLVVGAGLGGLSTAMFLARQGVRVLVVERRPGLSPY 43 >2GAG-B nrPDB Length = 405 Score = 39.9 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 20/67 (29%), Positives = 31/67 (46%), Gaps = 4/67 (5%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLG--FNTACVEKRGKLGGTCL-NVGCIPSKALLN- 78 KS+D +I+GGG G A A+ N A +EK GG N I S L + Sbjct: 18 PKKSYDAIIVGGGGHGLATAYFLAKNHGITNVAVLEKGWLAGGNMARNTTIIRSNYLWDE 77 Query: 79 NSHLFHQ 85 ++ ++ + Sbjct: 78 SAGIYEK 84 >1QO8-A nrPDB Length = 566 Score = 39.9 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 24/79 (30%), Positives = 41/79 (51%), Gaps = 2/79 (2%) Query: 227 GSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVED 286 G++V P G S E+ +K K+QG+D +L+++V+ NDD +VV VV Sbjct: 233 GARVDRTHR-PHGGKSSGPEIIDTLRKAAKEQGIDTRLNSRVVKLVVNDDHSVVGAVVHG 291 Query: 287 TKTNKQENLEAEVLLVAVG 305 T + A+ +++A G Sbjct: 292 KHTGYYM-IGAKSVVLATG 309 Score = 38.0 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 22/122 (18%), Positives = 51/122 (41%), Gaps = 12/122 (9%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHL 82 +++ V+++G G AG+ A++ A + G N V+K GG ++++ + Sbjct: 118 PSETTQVLVVGAGSAGFNASLAAKKAGANVILVDKAPFSGGN----------SMISAGGM 167 Query: 83 FHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFE 142 + G++ + I A + + +K +T E + V + + G+ Sbjct: 168 NAVGTKQQTAHGVEDKVEWFIEDAMKGGRQQNDIKLVTILAEQ--SADGVQWLESLGANL 225 Query: 143 DE 144 D+ Sbjct: 226 DD 227 >4TXK-A nrPDB Length = 615 Score = 39.5 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 13/29 (44%), Positives = 18/29 (62%) Query: 30 VIIGGGPAGYVAAIKAAQLGFNTACVEKR 58 +++G GP G AA++ A LG VEKR Sbjct: 88 LVVGAGPCGLRAAVELALLGARVVLVEKR 116 Score = 32.6 bits (73), Expect = 0.46, Method: Composition-based stats. Identities = 9/36 (25%), Positives = 18/36 (50%) Query: 206 RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGA 241 + ++G G GL + LG++V +VE + + Sbjct: 86 KCLVVGAGPCGLRAAVELALLGARVVLVEKRIKFSR 121 >2BRY-A nrPDB Length = 497 Score = 39.5 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 13/29 (44%), Positives = 18/29 (62%) Query: 30 VIIGGGPAGYVAAIKAAQLGFNTACVEKR 58 +++G GP G AA++ A LG VEKR Sbjct: 96 LVVGAGPCGLRAAVELALLGARVVLVEKR 124 Score = 32.6 bits (73), Expect = 0.46, Method: Composition-based stats. Identities = 9/36 (25%), Positives = 18/36 (50%) Query: 206 RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGA 241 + ++G G GL + LG++V +VE + + Sbjct: 94 KCLVVGAGPCGLRAAVELALLGARVVLVEKRIKFSR 129 >5CQF-A nrPDB Length = 443 Score = 39.5 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 54/399 (13%), Positives = 116/399 (29%), Gaps = 121/399 (30%) Query: 28 DVVIIGGGPAG--YVAAIKAAQ----------LGFNTACVEKRGKLGGTCLNVGCIPSKA 75 D + IG GPAG A + A+ +G+ A + + + Sbjct: 15 DAICIGFGPAGIALACAFEDAREASQPLGDLSIGYLEAAPDTQWH------------REL 62 Query: 76 LLNNSHLFHQMHTEA----------------------QKRGIDVNGDIKINVANFQKAKD 113 LL + + H + + G+ + +++ Sbjct: 63 LLAGTDINHHVFRDLVTPRNPRSRFSFAMYLKDQGRMFDFGLLGRPASRHEWSDYLGWVS 122 Query: 114 DAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVA 173 V G ++ NG + ++RV G +N++++ Sbjct: 123 RQVD---GHTRFDTPVTEIDPVIRNGRLQ---EVRVRTPQG---------SFATRNLVLS 167 Query: 174 TGSEVTPFPGIE-------IDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLE-------- 218 +GS E + ++ A K++PKR ++G G E Sbjct: 168 SGSAPRIPQAFEALLGPTLFHTSRFLTRLQAFG-KQLPKRWLVLGSGQSASESVLELVSR 226 Query: 219 -----------MGSV-YSRLGS---------KVTVVE-----FQPQIG--------ASMD 244 ++LG V + + A +D Sbjct: 227 DPAIEVHSVHRCAGFKLTQLGQFPNRVFAPDHVDYFHSLNPAARQRFLDWSRSTNYAGID 286 Query: 245 GEVAKATQKFLKKQGLDFKLS------TKVISAKRNDDKNVVEIVVEDTKTNKQENLEAE 298 + + + + + + + + + + D VE+ DT + + LE + Sbjct: 287 PDERQKLFSLIYEDSIAGRTRLHTYAYSVISAIEHTADGYRVELT--DTFSQRTRVLEVD 344 Query: 299 VLLVAVGRRPYIAGLGAEKIG--LEVDKRGRLVIDDQFN 335 +++ G + Y+ + L D G L+ID + Sbjct: 345 AVVLGTGYQQYLIPPLLSGLQPWLAADVDGGLLIDRDYR 383 >2ZXH-A nrPDB Length = 637 Score = 39.1 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 33/155 (21%), Positives = 50/155 (32%), Gaps = 9/155 (5%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQ 85 DVV+IGGG AG AA+ AA++G TA G C P+ + + + Sbjct: 27 EFDVVVIGGGHAGIEAALAAARMGAKTAMFVLNADTIGQM---SCNPAIGGIAKGIVVRE 83 Query: 86 MHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGG-----IELLFKKNKVTYYKGNGS 140 + + G ++ I K AV+ KK Sbjct: 84 IDALGGEMGKAIDQT-GIQFKMLNTRKGKAVQSPRAQADKKRYREYMKKVCENQENLYIK 142 Query: 141 FEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATG 175 E+ I V + K ++V TG Sbjct: 143 QEEVVDIIVKNNQVVGVRTNLGVEYKTKAVVVTTG 177 Score = 29.1 bits (64), Expect = 5.1, Method: Composition-based stats. Identities = 9/27 (33%), Positives = 16/27 (59%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVV 233 + +IGGG G+E +R+G+K + Sbjct: 30 VVVIGGGHAGIEAALAAARMGAKTAMF 56 >1RP0-A nrPDB Length = 284 Score = 39.1 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 22/128 (17%), Positives = 40/128 (31%), Gaps = 15/128 (11%) Query: 17 TVRTLTINKSH---DVVIIGGGPAGYVAAIKAAQL-GFNTACVEKRGKLGGTCLNVGCIP 72 T R +T ++ DVV++G G AG AA + ++ A +E+ GG Sbjct: 27 TRRYMTDMITYAETDVVVVGAGSAGLSAAYEISKNPNVQVAIIEQSVSPGG--------- 77 Query: 73 SKALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKV 132 LF M + + + A + + L + V Sbjct: 78 --GAWLGGQLFSAMIVRKPAHLFLDEIGVAYDEQDTYVVVKHAALFTSTIMSKLLARPNV 135 Query: 133 TYYKGNGS 140 + + Sbjct: 136 KLFNAVAA 143 >6HRD-A nrPDB Length = 317 Score = 39.1 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 20/105 (19%), Positives = 46/105 (43%), Gaps = 8/105 (7%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKL 264 +R+ ++G G +G + V +R G +VTV E + + + K+ ++ + + + Sbjct: 26 QRVGVVGAGQMGSGIAEVSARAGVEVTVFEPAEALITAGRNRIVKSLERAVSAGKVTERE 85 Query: 265 STKVISA--------KRNDDKNVVEIVVEDTKTNKQENLEAEVLL 301 + + +D + V+E VVED + E + ++ Sbjct: 86 RDRALGLLTFTTDLNDLSDRQLVIEAVVEDEAVKSEIFAELDRVV 130 >1C0L-A nrPDB Length = 363 Score = 39.1 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 10/31 (32%), Positives = 18/31 (58%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEF 235 KR+ ++G G+IGL + +R G V ++ Sbjct: 7 KRVVVLGSGVIGLSSALILARKGYSVHILAR 37 >5Z70-A nrPDB Length = 605 Score = 38.4 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 34/287 (11%), Positives = 75/287 (26%), Gaps = 34/287 (11%) Query: 31 IIGGGPAGYVAAIKA----AQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQM 86 IIG G AG +A G + ++ G GG+ G L+ + Sbjct: 9 IIGSGIAGLASAFYLIRDGRMKGQDITILDAVGTPGGSLDGSGNAEDGYLIRGGREMNWN 68 Query: 87 HTEAQKRGIDVNG-DIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDET 145 + D+ + + + + L K Sbjct: 69 YDHFWDLFQDIPALEYPSPYSVLDEYRAVNDNDPNWSKSRLMHKQGQIRDFSTLGLSSAH 128 Query: 146 KIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPK 205 + + + +D ++ + +E + + S A + Sbjct: 129 QWELIKLLLKRKEDLDDITIE----------QYFSDSFLETNFWYLWRSMFAFQNWQ--- 175 Query: 206 RLTIIGGGIIGLEMGSVYSRLGSKVT-VVEFQPQIGASMDG--EVAKATQKFLKKQGLDF 262 LE+ R + + + + + +LK QG++ Sbjct: 176 ---------SLLEVKLYMHRFLDAIDGLTDMSALVFPKYNQYDSFVVPLVNYLKGQGVNV 226 Query: 263 KLSTKVISAKRNDDKNVVEIV----VEDTKTNKQENLEAEVLLVAVG 305 + T+V D+ + D + K + +V+ G Sbjct: 227 EFGTRVYDLDMTDNNGERTVTSILAKVDGRDQKIDIGAKDVVFALTG 273 >5TUM-A nrPDB Length = 410 Score = 38.0 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 30/160 (18%), Positives = 57/160 (35%), Gaps = 10/160 (6%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKL--GGTCLNVGCIPS---KALL 77 ++K+ +++IG G AG + GF+ +EK + GG L+V I + + + Sbjct: 22 MSKNIKILVIGAGVAGPAVCYWLRRFGFSPVLIEKYASIRKGGQALDVRGIATHIAREMG 81 Query: 78 NNSHLFHQMHTEAQKRGIDVNGDIKINV--ANFQKAKDDAVKQLTGGIELLFKKNKVTYY 135 + + R +D +G + F +DD V+ L G + + K Sbjct: 82 IYDQICEMRTRIERGRFVDSSGKVLHEEQGEKFGFRQDDEVEILRGDLVEILMKTIADVP 141 Query: 136 KGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATG 175 + D + + I +I A G Sbjct: 142 CYFNQSIISIE---QNADNVTVIFMDGRIEQYDLVIAADG 178 >6C6P-A nrPDB Length = 458 Score = 38.0 bits (87), Expect = 0.010, Method: Composition-based stats. Identities = 13/29 (44%), Positives = 20/29 (68%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEF 235 + I+G G++G + +V SR G KVTV+E Sbjct: 10 VIIVGAGVLGSALAAVLSRDGRKVTVIER 38 >2XVH-A nrPDB Length = 464 Score = 38.0 bits (87), Expect = 0.010, Method: Composition-based stats. Identities = 41/231 (17%), Positives = 75/231 (32%), Gaps = 43/231 (18%) Query: 29 VVIIGGGPAGYVA--AIKAAQ-LGFNT---ACVEKRGKLGGTCLNVGCIPSKALLNNS-- 80 + I+G GP+G A ++AQ G C EK+ GG Sbjct: 5 IAILGAGPSGMAQLRAFQSAQEKGAEIPELVCFEKQADWGGQWNYT--------WRTGLD 56 Query: 81 HLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGI----------ELLFKKN 130 +H+ + + A++ D+ + + +K Sbjct: 57 ENGEPVHSSMYRYLWSNGPKECLEFADYT--FDEHFGKPIASYPPREVLWDYIKGRVEKA 114 Query: 131 KV-TYYKGNGSF------EDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGS----EVT 179 V Y + N + ED VT D T+ + + ++ TG V Sbjct: 115 GVRKYIRFNTAVRHVEFNEDSQTFTVTVQDHTTDTIYSE---EFDYVVCCTGHFSTPYVP 171 Query: 180 PFPGIEIDEEKIVSSTGALS-LKEIPKRLTIIGGGIIGLEMGSVYSRLGSK 229 F G E +I+ + L+ K + ++G ++GS + G+K Sbjct: 172 EFEGFEKFGGRILHAHDFRDALEFKDKTVLLVGSSYSAEDIGSQCYKYGAK 222 Score = 37.6 bits (86), Expect = 0.013, Method: Composition-based stats. Identities = 11/60 (18%), Positives = 26/60 (43%), Gaps = 2/60 (3%) Query: 249 KATQKFLKKQGLD--FKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGR 306 + ++K G+ + +T V + N+D + V+D T+ + E + ++ G Sbjct: 105 DYIKGRVEKAGVRKYIRFNTAVRHVEFNEDSQTFTVTVQDHTTDTIYSEEFDYVVCCTGH 164 >5KXJ-A nrPDB Length = 557 Score = 38.0 bits (87), Expect = 0.010, Method: Composition-based stats. Identities = 6/24 (25%), Positives = 14/24 (58%) Query: 326 GRLVIDDQFNSKFPHIKVVGDVTF 349 G +V+DD + + +G+V++ Sbjct: 355 GGVVVDDYGRTDVDGLYAIGEVSY 378 Score = 33.8 bits (76), Expect = 0.20, Method: Composition-based stats. Identities = 11/32 (34%), Positives = 16/32 (50%), Gaps = 1/32 (3%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRG 59 DV+IIG G AG A++ A+ + K Sbjct: 10 DVLIIGSGAAGLSLALRLAEKH-KVIVLSKGP 40 >4MOP-A nrPDB Length = 633 Score = 37.6 bits (86), Expect = 0.011, Method: Composition-based stats. Identities = 11/34 (32%), Positives = 18/34 (52%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVE 56 ++ +DVVI+G GP G A + G+ A + Sbjct: 43 MDIKYDVVIVGSGPIGCTYARELVGAGYKVAMFD 76 Score = 30.3 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 8/32 (25%), Positives = 12/32 (37%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQ 238 + I+G G IG G KV + + Sbjct: 49 VVIVGSGPIGCTYARELVGAGYKVAMFDIGEI 80 >1X14-A nrPDB Length = 401 Score = 37.2 bits (85), Expect = 0.016, Method: Composition-based stats. Identities = 12/56 (21%), Positives = 27/56 (48%) Query: 203 IPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQ 258 P ++ +IG G+ GL + LG+ V + +P++ + A+ + K++ Sbjct: 171 PPAKVMVIGAGVAGLAAIGAANSLGAIVRAFDTRPEVKEQVQSMGAEFLELDFKEE 226 Score = 28.0 bits (61), Expect = 9.5, Method: Composition-based stats. Identities = 11/33 (33%), Positives = 16/33 (48%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKL 61 V++IG G AG A A LG + R ++ Sbjct: 175 VMVIGAGVAGLAAIGAANSLGAIVRAFDTRPEV 207 >5AYV-A nrPDB Length = 309 Score = 37.2 bits (85), Expect = 0.016, Method: Composition-based stats. Identities = 25/134 (18%), Positives = 52/134 (38%), Gaps = 21/134 (15%) Query: 206 RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLS 265 R+ ++G G IG G++ +R G+ VT++ + Q+ + K + K Sbjct: 2 RIYVLGAGSIGSLFGALLARAGNDVTLIGRREQV-----DAINKNGLHVFGAEEFTVKPK 56 Query: 266 TKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYI------AGLGAEKIG 319 + + + D ++ + TKT + + +GR GLG E++ Sbjct: 57 ATIYAPEEPPDLLILAVKSYSTKTALECARQ------CIGR--NTWVLSIQNGLGNEELA 108 Query: 320 LEVDKR--GRLVID 331 L+ G + + Sbjct: 109 LKYTPNVMGGVTTN 122 >5GSN-A nrPDB Length = 453 Score = 36.8 bits (84), Expect = 0.019, Method: Composition-based stats. Identities = 38/223 (17%), Positives = 75/223 (33%), Gaps = 27/223 (12%) Query: 29 VVIIGGGPAGYV---AAIKAAQLGF---NTACVEKRGKLGGTCL---NVGCIPSKALLNN 79 V +IG GP+G A AA G C EK+ GG G + ++ Sbjct: 5 VAVIGAGPSGLAQLRAFQSAADQGAEIPEIVCFEKQANWGGLWNYTWRTGLDENGEPVHC 64 Query: 80 SHLFHQMHTEAQKRGIDV-NGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGN 138 S ++ + + K G++ + + + + + K + + Sbjct: 65 S-MYRYLWSNGPKEGLEFADYSFEEHFGKQIASYPPRAVLFDYIEGRVHKAD----VRKW 119 Query: 139 GSFEDETKIRVTPVDGLEGTVKE-----DHILDV--KNIIVATGS----EVTPFPGIEID 187 F + + + TV D ++I A+G V + G + Sbjct: 120 IRFNSPVRWVSYDAETAKFTVTAHNHETDSTYSAAFDHVICASGHFSTPNVPFYEGFDTF 179 Query: 188 EEKIVSSTGALSLKEI-PKRLTIIGGGIIGLEMGSVYSRLGSK 229 +IV + +E K + ++G ++GS + G+K Sbjct: 180 NGRIVHAHDFRDAREFEGKDVLVMGASSSAEDIGSQCWKYGAK 222 >4B68-A nrPDB Length = 501 Score = 36.8 bits (84), Expect = 0.020, Method: Composition-based stats. Identities = 19/112 (16%), Positives = 35/112 (31%), Gaps = 11/112 (9%) Query: 148 RVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSST------GALSLK 201 V + G + + +++A G G+ D I SS L K Sbjct: 187 TVRSRNVETGEISARRT---RKVVIAIGGTAKMPSGLPQDPRIIHSSKYCTTLPALLKDK 243 Query: 202 EIPKRLTIIGGGIIGLEMGSVYSRL--GSKVTVVEFQPQIGASMDGEVAKAT 251 P + ++G G E+ + S+ T++ + S D Sbjct: 244 SKPYNIAVLGSGQSAAEIFHDLQKRYPNSRTTLIMRDSAMRPSDDSPFVNEI 295 >5TUF-A nrPDB Length = 409 Score = 36.8 bits (84), Expect = 0.020, Method: Composition-based stats. Identities = 34/160 (21%), Positives = 61/160 (38%), Gaps = 10/160 (6%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKL--GGTCLNVGCIPS---KALL 77 + K +++IG G AG A + GF+ +EK + GG L++ I + K + Sbjct: 22 MTKHIKILVIGVGVAGPAVAYWLKRFGFSPVLIEKSAAVRKGGQALDIRGIATHIAKEMG 81 Query: 78 NNSHLFHQMHTEAQKRGIDVNGDIKINV--ANFQKAKDDAVKQLTGGIELLFKKNKVTYY 135 + + R +DV G++ F +DD V+ L G + + K Sbjct: 82 IYDQICNMRTQIKCGRYVDVKGNVLHEEQGETFGFRQDDEVEILRGDLVEILMKAIADIP 141 Query: 136 KGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNIIVATG 175 F+ D + T K+ + + +I A G Sbjct: 142 C---EFKQSVIKIEQNEDSVTVTYKDGRVENYDLVIAADG 178 >4K2X-A nrPDB Length = 523 Score = 36.8 bits (84), Expect = 0.021, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 18/35 (51%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKL 61 +DVVI G GP G + A + G T +E+ + Sbjct: 23 YDVVIAGAGPTGLMLACELRLAGARTLVLERLAEP 57 >4Z2R-A nrPDB Length = 592 Score = 36.8 bits (84), Expect = 0.024, Method: Composition-based stats. Identities = 12/37 (32%), Positives = 21/37 (56%) Query: 22 TINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKR 58 + + DV+I+G GPAG ++A A LG + + + Sbjct: 8 SNSAETDVLIVGAGPAGAMSATLLASLGIRSLMINRW 44 >3FPZ-A nrPDB Length = 326 Score = 36.8 bits (84), Expect = 0.024, Method: Composition-based stats. Identities = 12/38 (31%), Positives = 17/38 (44%), Gaps = 2/38 (5%) Query: 28 DVVIIGGGPAGYVAAIKAAQL--GFNTACVEKRGKLGG 63 DV+I+G G +G AA A+ +E GG Sbjct: 67 DVIIVGAGSSGLSAAYVIAKNRPDLKVCIIESSVAPGG 104 >3KYB-A nrPDB Length = 390 Score = 36.4 bits (83), Expect = 0.025, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 19/35 (54%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQI 239 K++ I+G G G +G + G +V +++ + I Sbjct: 4 KKILIVGAGFSGAVIGRQLAEKGHQVHIIDQRDHI 38 Score = 32.6 bits (73), Expect = 0.42, Method: Composition-based stats. Identities = 19/98 (19%), Positives = 42/98 (42%), Gaps = 3/98 (3%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLN--NSH 81 KS ++I+G G +G V + A+ G +++R +GG + + +++ H Sbjct: 1 MKSKKILIVGAGFSGAVIGRQLAEKGHQVHIIDQRDHIGGNSYDARDSETNVMVHVYGPH 60 Query: 82 LFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQL 119 +FH + I+ + ++ V + + V L Sbjct: 61 IFHTDNETVWNY-INKHAEMMPYVNRVKATVNGQVFSL 97 >1KNR-A nrPDB Length = 540 Score = 36.4 bits (83), Expect = 0.026, Method: Composition-based stats. Identities = 5/24 (20%), Positives = 14/24 (58%) Query: 326 GRLVIDDQFNSKFPHIKVVGDVTF 349 G +++DD + + +G+V++ Sbjct: 355 GGVMVDDHGRTDVEGLYAIGEVSY 378 Score = 31.8 bits (71), Expect = 0.76, Method: Composition-based stats. Identities = 10/22 (45%), Positives = 13/22 (59%) Query: 28 DVVIIGGGPAGYVAAIKAAQLG 49 DV+IIG G AG A++ A Sbjct: 10 DVLIIGSGAAGLSLALRLADQH 31 >2E5V-A nrPDB Length = 472 Score = 36.4 bits (83), Expect = 0.027, Method: Composition-based stats. Identities = 31/174 (17%), Positives = 56/174 (32%), Gaps = 31/174 (17%) Query: 31 IIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCI---------PS-------- 73 IIG G AG A + + G + KR G T + G + P Sbjct: 4 IIGSGIAGLSAGVALRRAGKKVTLISKRIDGGSTPIAKGGVAASVGSDDSPELHAQDTIR 63 Query: 74 --------KALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIEL 125 K + + + + G + D+++ + ++ + I Sbjct: 64 VGDGLCDVKTVNYVTSEAKNVIETFESWGFEFEEDLRLEGGHTKRRVLHRTDETGREIFN 123 Query: 126 LFKKNKVTYYKGNGSFEDETKIRVTPVDGLEG---TVKEDHILDVKNIIVATGS 176 K+ +G ED + + DG T K + DV +++ATG Sbjct: 124 FLL--KLAREEGIPIIEDR-LVEIRVKDGKVTGFVTEKRGLVEDVDKLVLATGG 174 Score = 30.7 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 13/28 (46%), Positives = 16/28 (57%) Query: 209 IIGGGIIGLEMGSVYSRLGSKVTVVEFQ 236 IIG GI GL G R G KVT++ + Sbjct: 4 IIGSGIAGLSAGVALRRAGKKVTLISKR 31 >3BI4-A nrPDB Length = 516 Score = 36.4 bits (83), Expect = 0.031, Method: Composition-based stats. Identities = 17/47 (36%), Positives = 25/47 (53%), Gaps = 2/47 (4%) Query: 18 VRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGF-NTACVEKRGKLGG 63 + T++ K V+IIG G AG AA Q G + +E R ++GG Sbjct: 1 MNTVSPAKK-KVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGG 46 Score = 35.7 bits (81), Expect = 0.048, Method: Composition-based stats. Identities = 13/40 (32%), Positives = 22/40 (55%), Gaps = 1/40 (2%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGS-KVTVVEFQPQIGASM 243 K++ IIG GI GL+ S + G V+E + ++G + Sbjct: 9 KKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGRL 48 >1KSU-A nrPDB Length = 571 Score = 36.4 bits (83), Expect = 0.031, Method: Composition-based stats. Identities = 29/141 (20%), Positives = 54/141 (38%), Gaps = 19/141 (13%) Query: 227 GSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVED 286 G+ V P GA + V + K+ +D +++T+ I ++D V I+V+ Sbjct: 238 GASVNRAHR-PTGGAGVGAHVVQVLYDNAVKRNIDLRMNTRGIEVLKDDKGTVKGILVKG 296 Query: 287 TKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKRGRLVIDDQFNSKFPHIKVVGD 346 ++A+ +++A G A L+ +G + ++ P VGD Sbjct: 297 MYKGYYW-VKADAVILATG---GFAKNNERVAKLDPSLKGFI------STNQPG--AVGD 344 Query: 347 VTFGPMLAHKAEEEGIAAVEM 367 AE G A +M Sbjct: 345 GLD------VAENAGGALKDM 359 Score = 29.5 bits (65), Expect = 3.2, Method: Composition-based stats. Identities = 9/25 (36%), Positives = 12/25 (48%) Query: 39 YVAAIKAAQLGFNTACVEKRGKLGG 63 + AAI A G +EK +GG Sbjct: 139 FSAAISATDSGAKVILIEKEPVIGG 163 >2VHY-A nrPDB Length = 377 Score = 36.1 bits (82), Expect = 0.032, Method: Composition-based stats. Identities = 13/29 (44%), Positives = 17/29 (58%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVE 56 DVV+IG G AGY AA A +G ++ Sbjct: 170 DVVVIGAGTAGYNAARIANGMGATVTVLD 198 Score = 33.8 bits (76), Expect = 0.18, Method: Composition-based stats. Identities = 11/44 (25%), Positives = 20/44 (45%) Query: 204 PKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEV 247 P + +IG G G + + +G+ VTV++ +D E Sbjct: 168 PADVVVIGAGTAGYNAARIANGMGATVTVLDINIDKLRQLDAEF 211 >1FOH-A nrPDB Length = 664 Score = 36.1 bits (82), Expect = 0.034, Method: Composition-based stats. Identities = 13/43 (30%), Positives = 23/43 (53%), Gaps = 6/43 (13%) Query: 24 NKSH-DVVIIGGGPAGYVAAIKAAQL-----GFNTACVEKRGK 60 ++S+ DV+I+G GPAG +AA ++ ++KR Sbjct: 4 SESYCDVLIVGAGPAGLMAARVLSEYVRQKPDLKVRIIDKRST 46 >3G5Q-A nrPDB Length = 443 Score = 36.1 bits (82), Expect = 0.038, Method: Composition-based stats. Identities = 11/34 (32%), Positives = 19/34 (55%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQ 238 +R+ ++G G+ G E RLG V + E +P+ Sbjct: 2 ERVNVVGAGLAGSEAAWTLLRLGVPVRLFEMRPK 35 Score = 28.7 bits (63), Expect = 5.2, Method: Composition-based stats. Identities = 11/30 (36%), Positives = 14/30 (46%) Query: 31 IIGGGPAGYVAAIKAAQLGFNTACVEKRGK 60 ++G G AG AA +LG E R K Sbjct: 6 VVGAGLAGSEAAWTLLRLGVPVRLFEMRPK 35 >3OZ2-A nrPDB Length = 397 Score = 35.7 bits (81), Expect = 0.042, Method: Composition-based stats. Identities = 10/23 (43%), Positives = 14/23 (60%) Query: 40 VAAIKAAQLGFNTACVEKRGKLG 62 AA AA+ G T +EKR ++G Sbjct: 18 TAARYAAKYGLKTLMIEKRPEIG 40 >1F14-A nrPDB Length = 310 Score = 35.7 bits (81), Expect = 0.044, Method: Composition-based stats. Identities = 19/100 (19%), Positives = 42/100 (42%), Gaps = 7/100 (7%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKL 264 K +T+IGGG++G + V + G V +V+ I A + ++ +K KK+ Sbjct: 16 KHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKKK-----F 70 Query: 265 STKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAV 304 + + +K + I + ++++ A+ Sbjct: 71 AENPKAGDECVEKTLSTIAT--STDAASVVHSTDLVVEAI 108 >5XGV-A nrPDB Length = 462 Score = 35.7 bits (81), Expect = 0.053, Method: Composition-based stats. Identities = 12/56 (21%), Positives = 21/56 (37%), Gaps = 1/56 (1%) Query: 206 RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIG-ASMDGEVAKATQKFLKKQGL 260 + I GGG +GL + G V+E S G + + ++G+ Sbjct: 3 TVIIAGGGPVGLMLACELGLAGVDTVVLERHDAPREPSRGGAINATVVELFTQRGI 58 Score = 33.0 bits (74), Expect = 0.27, Method: Composition-based stats. Identities = 33/178 (18%), Positives = 65/178 (36%), Gaps = 18/178 (10%) Query: 28 DVVII-GGGPAGYVAAIKAAQLGFNTACVEKRGKL-----GGTCLNVGCIPSKALLNNSH 81 D VII GGGP G + A + G +T +E+ GG +N + L Sbjct: 2 DTVIIAGGGPVGLMLACELGLAGVDTVVLERHDAPREPSRGGA-INATVV---ELFTQRG 57 Query: 82 LFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSF 141 + + + + + I + + + +E ++ + Sbjct: 58 IMESLRDDGFEFRMAHFAHIPLAPERVPGDRAFSFAVPHAQVERRLEERARSLGVRVRRS 117 Query: 142 EDETKIRVTPVDGLEGTVKEDHILDVKNIIVATGSEVT-------PFPGIEIDEEKIV 192 + T +R TP DG++ T + +++ ++ GS PFPG++ D + Sbjct: 118 TEITSVRQTP-DGVQVTTGDGEVVEGAYLVGCDGSASLVREQAGIPFPGVDPDFHGLW 174 >6DLL-A nrPDB Length = 398 Score = 35.3 bits (80), Expect = 0.060, Method: Composition-based stats. Identities = 20/90 (22%), Positives = 39/90 (43%), Gaps = 7/90 (7%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLST 266 + IIG G GL +G + + G +VE Q + + + + L++ +D Sbjct: 8 VAIIGAGPSGLLLGQLLHKAGIDNIIVERQ-----TAEYVLGRIRAGVLEQGTVDLLREA 62 Query: 267 KVISAKRNDDKNVVEIVVEDTKTNKQENLE 296 V +R D + +V VE +++ L+ Sbjct: 63 GVA--ERMDREGLVHEGVELLVGGRRQRLD 90 >6MO6-A nrPDB Length = 414 Score = 35.3 bits (80), Expect = 0.061, Method: Composition-based stats. Identities = 25/121 (20%), Positives = 50/121 (41%), Gaps = 12/121 (9%) Query: 248 AKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRR 307 A A Q+ ++++ L +I + + + V E K + + + E+L V Sbjct: 203 ADALQEIIQERNLTVNYKKNLIEVRADKQEAVFE---NLDKPGETQVISYEMLHVT---- 255 Query: 308 PYIAGLGAEKIGLEVDKRGRLVIDDQ--FNSKFPHIKVVGDVTFGP---MLAHKAEEEGI 362 P ++ K D G + +D + + ++P++ +GD T P A A + GI Sbjct: 256 PPMSPPDVLKTSPVADAAGWVDVDKETLQHRRYPNVFGIGDCTNLPTSKTAAAVAAQSGI 315 Query: 363 A 363 Sbjct: 316 L 316 >4UIR-A nrPDB Length = 646 Score = 35.3 bits (80), Expect = 0.063, Method: Composition-based stats. Identities = 48/309 (15%), Positives = 101/309 (32%), Gaps = 37/309 (11%) Query: 9 NNKRAFSSTVRTLTINKSHDVVIIGGGPAGYVAAIKAAQLG----FNTACVEKRGKLGGT 64 N +R V++ +K + IIG G AG AA + G N +E+ GG+ Sbjct: 48 NYQRNKGIPVQSYDNSKIY---IIGSGIAGMSAAYYFIRDGHVPAKNITFLEQLHIDGGS 104 Query: 65 CLNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIE 124 G ++ + + + D+ +L + Sbjct: 105 LDGAGNPTDGYIIRGGREMDMTYENLWDM---FQDIPALEMPAPYSVLDEY--RLINDND 159 Query: 125 LLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGT-VKEDHILDVKNIIVATGSEVTPFPG 183 + +K G +D +K + +D L + + ++ ++ + + Sbjct: 160 SNY--SKARLINNKGEIKDFSKFGLNKMDQLAIIRLLLKNKEELDDLTI------EDYFS 211 Query: 184 IEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVT-VVEFQPQIGAS 242 + + + E L LE+ R + + + + Sbjct: 212 ESFLKSNFWTFWRTMFAFENWHSL---------LELKLYMHRFLHAIDGLNDLSSLVFPK 262 Query: 243 MDG--EVAKATQKFLKKQGLDFKLSTKVI--SAKRNDDKNVVE--IVVEDTKTNKQENLE 296 + +KFL+++G++ L+T V N + VVE I +D K K + Sbjct: 263 YNQYDTFVTPLRKFLQEKGVNIHLNTLVKDLDIHINTEGKVVEGIITEQDGKEVKIPVGK 322 Query: 297 AEVLLVAVG 305 + ++V G Sbjct: 323 NDYVIVTTG 331 >3WE0-A nrPDB Length = 580 Score = 35.3 bits (80), Expect = 0.069, Method: Composition-based stats. Identities = 15/36 (41%), Positives = 20/36 (55%), Gaps = 1/36 (2%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 +V I+G G AG VAA + +LG E K+GG Sbjct: 67 EVAIVGAGIAGLVAAYELMKLGLKPVVYEA-SKMGG 101 >4IV9-A nrPDB Length = 557 Score = 34.9 bits (79), Expect = 0.072, Method: Composition-based stats. Identities = 14/43 (32%), Positives = 22/43 (51%), Gaps = 1/43 (2%) Query: 206 RLTIIGGGIIGLEMGSVYSRLGS-KVTVVEFQPQIGASMDGEV 247 R+ I+G GI GL + R G V + E + +IG + +V Sbjct: 40 RVAIVGAGISGLVAATELLRAGVKDVVLYESRDRIGGRVWSQV 82 Score = 33.8 bits (76), Expect = 0.16, Method: Composition-based stats. Identities = 13/36 (36%), Positives = 19/36 (52%), Gaps = 1/36 (2%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFN-TACVEKRGKLGG 63 V I+G G +G VAA + + G E R ++GG Sbjct: 41 VAIVGAGISGLVAATELLRAGVKDVVLYESRDRIGG 76 >3HDH-A nrPDB Length = 302 Score = 34.9 bits (79), Expect = 0.072, Method: Composition-based stats. Identities = 19/100 (19%), Positives = 42/100 (42%), Gaps = 7/100 (7%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKL 264 K +T+IGGG++G + V + G V +V+ I A + ++ +K KK+ Sbjct: 16 KHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKKK-----F 70 Query: 265 STKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAV 304 + + +K + I + ++++ A+ Sbjct: 71 AENPKAGDEFVEKTLSSIST--STDAASVVHSTDLVVEAI 108 >3S61-A nrPDB Length = 463 Score = 34.9 bits (79), Expect = 0.073, Method: Composition-based stats. Identities = 30/199 (15%), Positives = 54/199 (27%), Gaps = 66/199 (33%) Query: 204 PKRLTIIGGGIIGLEM------------------GSVYSRLGSKVTVVEF---------- 235 P ++ IIGGG E S V E Sbjct: 227 PMKIAIIGGGQSAAEAFIDLNDSYPSVQADMILRASALKPADDSPFVNEVFAPKFTDLIY 286 Query: 236 ------QPQIGASM--------DGEVAKATQKFLKKQGLD------FKLSTKVISAKRND 275 + ++ D ++ + +Q + F+ T V A Sbjct: 287 SREHAERERLLREYHNTNYSVVDTDLIERIYGVFYRQKVSGIPRHAFRCMTTVERATATA 346 Query: 276 DKNVVEIVVEDTKTNKQENLEAEVLLVAVG---------RRPYIAGLGAEKIGLEVDKRG 326 +E+ + D + + + +++A G P LG +IG + Sbjct: 347 QG--IELALRDAGSGELSVETYDAVILATGYERQLHRQLLEPLAEYLGDHEIGRDY---- 400 Query: 327 RLVIDDQFNSKFPHIKVVG 345 RL D++ I G Sbjct: 401 RLQTDERCKV---AIYAQG 416 >1DOD-A nrPDB Length = 394 Score = 34.5 bits (78), Expect = 0.098, Method: Composition-based stats. Identities = 15/58 (25%), Positives = 27/58 (46%), Gaps = 3/58 (5%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQ---IGASMDGEVAKATQKFLKKQGLD 261 + IIG G GL +G + + G ++E Q +G G + + L++ G+D Sbjct: 5 VAIIGAGPSGLLLGQLLHKAGIDNVILERQTPDYVLGRIRAGVLEQGMVDLLREAGVD 62 >3LOV-A nrPDB Length = 475 Score = 34.5 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 14/37 (37%), Positives = 19/37 (51%), Gaps = 2/37 (5%) Query: 29 VVIIGGGPAGYVAAIKAAQL--GFNTACVEKRGKLGG 63 +VI+GGG G AA A + N +E +LGG Sbjct: 7 LVIVGGGITGLAAAYYAERAFPDLNITLLEAGERLGG 43 Score = 30.7 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 14/41 (34%), Positives = 21/41 (51%), Gaps = 2/41 (4%) Query: 205 KRLTIIGGGIIGLEMGSVYSRL--GSKVTVVEFQPQIGASM 243 KRL I+GGGI GL R +T++E ++G + Sbjct: 5 KRLVIVGGGITGLAAAYYAERAFPDLNITLLEAGERLGGKV 45 >4H7U-A nrPDB Length = 602 Score = 34.5 bits (78), Expect = 0.12, Method: Composition-based stats. Identities = 9/34 (26%), Positives = 17/34 (50%), Gaps = 1/34 (2%) Query: 27 HDVVIIGGGPAGYVAAIKAAQ-LGFNTACVEKRG 59 +D ++ GGG AG V A + ++ + +E Sbjct: 41 YDFIVAGGGTAGLVVASRLSENSNWKVLVIEAGP 74 >2GV8-A nrPDB Length = 447 Score = 34.5 bits (78), Expect = 0.12, Method: Composition-based stats. Identities = 14/38 (36%), Positives = 18/38 (47%), Gaps = 2/38 (5%) Query: 29 VVIIGGGPAGYVAAIK--AAQLGFNTACVEKRGKLGGT 64 + IIG GP+G V A A + E+RG GG Sbjct: 9 IAIIGAGPSGLVTAKALLAEKAFDQVTLFERRGSPGGV 46 >3COX-A nrPDB Length = 507 Score = 34.1 bits (77), Expect = 0.13, Method: Composition-based stats. Identities = 24/86 (27%), Positives = 31/86 (36%), Gaps = 13/86 (15%) Query: 19 RTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVE---KRGKLG--GT----CLNVG 69 RTL ++IG G G VAA++ Q G T VE G G LN Sbjct: 4 RTLADGDRVPALVIGSGYGGAVAALRLTQAGIPTQIVEMGRSWDTPGSDGKIFCGMLN-- 61 Query: 70 CIPSKALLNNSHLFHQMHTEAQKRGI 95 P K + + Q + GI Sbjct: 62 --PDKRSMWLADKTDQPVSNFMGFGI 85 >1LTX-R nrPDB Length = 650 Score = 34.1 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 13/38 (34%), Positives = 19/38 (50%), Gaps = 2/38 (5%) Query: 27 HDVVIIGGG-PAGYVAAIKAAQLGFNTACVEKRGKLGG 63 DV++IG G P +AA ++ G V+ R GG Sbjct: 9 FDVIVIGTGLPESIIAAA-CSRSGQRVLHVDSRSYYGG 45 >3CP2-A nrPDB Length = 649 Score = 34.1 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 31/154 (20%), Positives = 53/154 (34%), Gaps = 9/154 (5%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQM 86 DV+IIGGG AG AA+ AA++G T + G C P+ + HL ++ Sbjct: 27 FDVIIIGGGHAGTEAAMAAARMGQQTLLLTHNIDTLGQM---SCNPAIGGIGKGHLVKEV 83 Query: 87 HTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYK----GNGSFE 142 I +K AV+ + + + V F+ Sbjct: 84 DA-LGGLMAKAIDQAGIQFRILNASKGPAVRATRAQADRVLYRQAVRTALENQPNLMIFQ 142 Query: 143 DETKIRVTPVDGLEGTVKE-DHILDVKNIIVATG 175 + + D + G V + K +++ G Sbjct: 143 QAVEDLIVENDRVVGAVTQMGLKFRAKAVVLTVG 176 >3G05-A nrPDB Length = 576 Score = 34.1 bits (77), Expect = 0.14, Method: Composition-based stats. Identities = 31/154 (20%), Positives = 53/154 (34%), Gaps = 9/154 (5%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQM 86 DV+IIGGG AG AA+ AA++G T + G C P+ + HL ++ Sbjct: 33 FDVIIIGGGHAGTEAAMAAARMGQQTLLLTHNIDTLGQM---SCNPAIGGIGKGHLVKEV 89 Query: 87 HTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYK----GNGSFE 142 I +K AV+ + + + V F+ Sbjct: 90 DA-LGGLMAKAIDQAGIQFRILNASKGPAVRATRAQADRVLYRQAVRTALENQPNLMIFQ 148 Query: 143 DETKIRVTPVDGLEGTVKE-DHILDVKNIIVATG 175 + + D + G V + K +++ G Sbjct: 149 QAVEDLIVENDRVVGAVTQMGLKFRAKAVVLTVG 182 >3HN2-A nrPDB Length = 312 Score = 33.8 bits (76), Expect = 0.17, Method: Composition-based stats. Identities = 10/32 (31%), Positives = 17/32 (53%) Query: 206 RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQP 237 R+ I+G G +GL G++ R G V + + Sbjct: 4 RIAIVGAGALGLYYGALLQRSGEDVHFLLRRD 35 >6ACQ-A nrPDB Length = 302 Score = 33.4 bits (75), Expect = 0.24, Method: Composition-based stats. Identities = 17/102 (16%), Positives = 37/102 (36%), Gaps = 19/102 (18%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFK- 263 K++ +IG G +G + ++ G +V + + + +GLDF Sbjct: 22 KKVCVIGAGTMGSGIAQAFAAKGFEVVL----------------RDIKDEFVDRGLDFIN 65 Query: 264 --LSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVA 303 LS V K + V + + + ++++ A Sbjct: 66 KNLSKLVKKGKIEEATKVEILTRISGTVDLNMAADCDLVIEA 107 >5KNK-B nrPDB Length = 333 Score = 33.4 bits (75), Expect = 0.25, Method: Composition-based stats. Identities = 22/145 (15%), Positives = 50/145 (34%), Gaps = 10/145 (6%) Query: 43 IKAAQLGFNTACV-EKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEA--------QKR 93 KA + G T + + +GG +N +P + ++ L + +A + Sbjct: 184 FKALKQGETTVILPDHTPNVGGDMVNYFGVPLASSNLSAKLIQKTKAKALFLYAIRNEND 243 Query: 94 GIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVD 153 G ++ + ++ ++ DD + IE L + Y+ F+ + Sbjct: 244 GFTMHIEP-MDEKIYEGTADDGTYVIHQAIEQLIYQYPEHYHWSYKRFKANPALDNIYNI 302 Query: 154 GLEGTVKEDHILDVKNIIVATGSEV 178 +K L + + +T E Sbjct: 303 DPTEALKIVDRLKAEALKTSTQPEP 327 >5Y77-A nrPDB Length = 473 Score = 33.4 bits (75), Expect = 0.26, Method: Composition-based stats. Identities = 26/147 (17%), Positives = 54/147 (36%), Gaps = 8/147 (5%) Query: 202 EIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQ--PQIGASMDGEVAKATQKFLKKQG 259 + +++TIIG G+ G + + +R G +V + E + P+I G Sbjct: 6 DNARQVTIIGAGLAGTLVARLLARNGWQVNLFERRPDPRIETGARGRSINLALAERGAHA 65 Query: 260 LDFK-LSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGL--GAE 316 L L +V++ +V + ++E ++ ++ R L GAE Sbjct: 66 LRLAGLEREVLAEAVMMRGRMVHVPGTPPNLQPYGRDDSE-VIWSINRDRLNRILLDGAE 124 Query: 317 KIGLEVDKR-GRLVID-DQFNSKFPHI 341 G + G +D + ++ Sbjct: 125 AAGASIHFNLGLDSVDFARQRLTLSNV 151 Score = 32.2 bits (72), Expect = 0.55, Method: Composition-based stats. Identities = 12/33 (36%), Positives = 16/33 (48%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKL 61 V IIG G AG + A A+ G+ E+R Sbjct: 11 VTIIGAGLAGTLVARLLARNGWQVNLFERRPDP 43 >5EZ7-A nrPDB Length = 392 Score = 33.4 bits (75), Expect = 0.27, Method: Composition-based stats. Identities = 13/39 (33%), Positives = 20/39 (51%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCL 66 D++I+GGG AG + + G+ T VE GG + Sbjct: 9 DILIVGGGIAGLWLNARLRRAGYATVLVESASLGGGQSV 47 >3L1R-A nrPDB Length = 478 Score = 33.0 bits (74), Expect = 0.27, Method: Composition-based stats. Identities = 10/36 (27%), Positives = 20/36 (55%), Gaps = 1/36 (2%) Query: 29 VVIIGGGPAGYVAAIKAAQLGF-NTACVEKRGKLGG 63 V+++G G +G AA + ++ G + +E +GG Sbjct: 7 VIVVGAGMSGISAAKRLSEAGITDLLILEATDHIGG 42 >2DKH-A nrPDB Length = 639 Score = 33.0 bits (74), Expect = 0.28, Method: Composition-based stats. Identities = 15/35 (42%), Positives = 19/35 (54%), Gaps = 1/35 (2%) Query: 28 DVVIIGGGPAGYV-AAIKAAQLGFNTACVEKRGKL 61 DV+I+G GPAG AA AA T VE++ Sbjct: 34 DVLIVGCGPAGLTLAAQLAAFPDIRTCIVEQKEGP 68 >1GPE-A nrPDB Length = 587 Score = 33.0 bits (74), Expect = 0.30, Method: Composition-based stats. Identities = 11/34 (32%), Positives = 16/34 (47%), Gaps = 1/34 (2%) Query: 25 KSHDVVIIGGGPAGYVAAIKAAQL-GFNTACVEK 57 K++D +I GGG G A K + +EK Sbjct: 23 KTYDYIIAGGGLTGLTVAAKLTENPKIKVLVIEK 56 >4MIF-A nrPDB Length = 620 Score = 33.0 bits (74), Expect = 0.32, Method: Composition-based stats. Identities = 10/30 (33%), Positives = 11/30 (36%) Query: 27 HDVVIIGGGPAGYVAAIKAAQLGFNTACVE 56 +DV I G GP G A VE Sbjct: 14 YDVFIAGSGPIGATFAKLCVDANLRVCMVE 43 >3SM8-A nrPDB Length = 381 Score = 33.0 bits (74), Expect = 0.33, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 15/35 (42%), Gaps = 1/35 (2%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLG 62 D ++IG G AG + G +E+ + G Sbjct: 11 DYLVIGAGIAGASTGYWLSAHG-RVVVLEREAQPG 44 >2BS2-A nrPDB Length = 660 Score = 33.0 bits (74), Expect = 0.34, Method: Composition-based stats. Identities = 12/34 (35%), Positives = 19/34 (55%), Gaps = 1/34 (2%) Query: 23 INKSH-DVVIIGGGPAGYVAAIKAAQLGFNTACV 55 + + D ++IGGG AG AA+ Q G +T + Sbjct: 1 MKVQYCDSLVIGGGLAGLRAAVATQQKGLSTIVL 34 >1UIR-A nrPDB Length = 314 Score = 33.0 bits (74), Expect = 0.35, Method: Composition-based stats. Identities = 17/100 (17%), Positives = 40/100 (40%), Gaps = 21/100 (21%) Query: 204 PKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFK 263 PKR+ I+GGG G+ + TV + + +DGE+ + ++ + Sbjct: 78 PKRVLIVGGG-----EGATLREVLKHPTV---EKAVMVDIDGELVEVAKRHM-------- 121 Query: 264 LSTKVISAKRNDDKNVVEIVVEDTKTN-KQENLEAEVLLV 302 + D +V++D + ++ +V+++ Sbjct: 122 ----PEWHQGAFDDPRAVLVIDDARAYLERTEERYDVVII 157 >3GMC-A nrPDB Length = 415 Score = 33.0 bits (74), Expect = 0.35, Method: Composition-based stats. Identities = 34/181 (18%), Positives = 57/181 (31%), Gaps = 25/181 (13%) Query: 31 IIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMHTEA 90 + GGG AG AAI Q G++ EK +L +A +L+H Sbjct: 52 VAGGGFAGLTAAIALKQNGWDVRLHEKSSEL------------RAFGAGIYLWHNGLRVL 99 Query: 91 QKRG----IDVNGDIKINVANFQKAKDDAVKQLTGG-----IELLFKKNKVTYYKGNGSF 141 + G + + K + + G V + G Sbjct: 100 EGLGALDDVLQGSHTPPTYETWMHNKSVSKETFNGLPWRIMTRSHLHDALVNRARALGVD 159 Query: 142 EDETKIRVTPVDGLEGTVKEDHILDVKNIIVA--TGSEVTPFPGIEIDEEKIVSSTGALS 199 V T++ +L+ I+ A GS+V I +++ VS G + Sbjct: 160 ISVNSEAVAADPVGRLTLQTGEVLEADLIVGADGVGSKVRD--SIGFKQDRWVSKDGLIR 217 Query: 200 L 200 L Sbjct: 218 L 218 Score = 29.9 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 10/37 (27%), Positives = 16/37 (43%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGA 241 +R + GGG GL + G V + E ++ A Sbjct: 48 RRAEVAGGGFAGLTAAIALKQNGWDVRLHEKSSELRA 84 >4IVM-B nrPDB Length = 483 Score = 32.6 bits (73), Expect = 0.37, Method: Composition-based stats. Identities = 12/37 (32%), Positives = 19/37 (51%), Gaps = 2/37 (5%) Query: 29 VVIIGGGPAGYVAAIKAAQL--GFNTACVEKRGKLGG 63 VV++GGG +G A+ ++ VE +LGG Sbjct: 11 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGG 47 >3IHM-A nrPDB Length = 430 Score = 32.6 bits (73), Expect = 0.39, Method: Composition-based stats. Identities = 11/28 (39%), Positives = 15/28 (53%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTV 232 KR+ I+G G GL +G + VTV Sbjct: 23 KRIGIVGAGTAGLHLGLFLRQHDVDVTV 50 >1LQU-A nrPDB Length = 456 Score = 32.6 bits (73), Expect = 0.41, Method: Composition-based stats. Identities = 22/168 (13%), Positives = 55/168 (32%), Gaps = 35/168 (20%) Query: 156 EGTVKEDHILDVKNIIVATGS---EVTPFPGIEIDEE----KIVSSTGA------LSLKE 202 E + +I A G+ + PG ++ V A +S Sbjct: 86 EHVQPGELSERYDAVIYAVGAQSDRMLNIPGEDLPGSIAAVDFVGWYNAHPHFEQVSPDL 145 Query: 203 IPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLD- 261 R +IG G + L++ + + V+ +A + L+ +G+ Sbjct: 146 SGARAVVIGNGNVALDVARILL---TDPDVLARTD---------IADHALESLRPRGIQE 193 Query: 262 ---------FKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVL 300 + + + + D + V++V++ + + + +A + Sbjct: 194 VVIVGRRGPLQAAFTTLELRELADLDGVDVVIDPAELDGITDEDAAAV 241 >5X6R-A nrPDB Length = 420 Score = 32.6 bits (73), Expect = 0.41, Method: Composition-based stats. Identities = 10/34 (29%), Positives = 20/34 (58%) Query: 203 IPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQ 236 + + + IIG G++G +S+ G VT+ +F+ Sbjct: 27 MSESVAIIGAGLVGCLAALAFSKEGYNVTLYDFR 60 >4YNU-A nrPDB Length = 571 Score = 32.6 bits (73), Expect = 0.42, Method: Composition-based stats. Identities = 8/36 (22%), Positives = 19/36 (52%), Gaps = 1/36 (2%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQL-GFNTACVEK 57 ++D +++GGG +G V A + ++ + +E Sbjct: 2 NTTTYDYIVVGGGTSGLVVANRLSENPDVSVLLLEA 37 >6J0Z-C nrPDB Length = 491 Score = 32.6 bits (73), Expect = 0.46, Method: Composition-based stats. Identities = 10/34 (29%), Positives = 18/34 (52%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKL 61 DVV++G GP G + A + G + ++K + Sbjct: 7 DVVVVGAGPTGLMLAGELRLAGVSVVVLDKLAEP 40 Score = 32.2 bits (72), Expect = 0.54, Method: Composition-based stats. Identities = 7/41 (17%), Positives = 15/41 (36%) Query: 201 KEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGA 241 + + ++G G GL + G V V++ + Sbjct: 2 EFYDSDVVVVGAGPTGLMLAGELRLAGVSVVVLDKLAEPIK 42 >3JSK-A nrPDB Length = 344 Score = 32.2 bits (72), Expect = 0.51, Method: Composition-based stats. Identities = 13/38 (34%), Positives = 16/38 (42%), Gaps = 2/38 (5%) Query: 28 DVVIIGGGPAGYVAAIKAAQL--GFNTACVEKRGKLGG 63 D+VI+G G G AA + L VE GG Sbjct: 81 DIVIVGAGSCGLSAAYVLSTLRPDLRITIVEAGVAPGG 118 >3I6D-A nrPDB Length = 470 Score = 32.2 bits (72), Expect = 0.54, Method: Composition-based stats. Identities = 15/41 (36%), Positives = 18/41 (43%), Gaps = 6/41 (14%) Query: 29 VVIIGGGPAGYVAAIKAAQ------LGFNTACVEKRGKLGG 63 VVIIGGG G AA + L VE ++GG Sbjct: 8 VVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASPRVGG 48 Score = 30.3 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 22/92 (23%), Positives = 40/92 (43%), Gaps = 11/92 (11%) Query: 205 KRLTIIGGGIIGLEMGSVY-------SRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKK 257 K + IIGGGI GL + Y L ++T+VE P++G + ++ + Sbjct: 6 KHVVIIGGGITGL-AAAFYMEKEIKEKNLPLELTLVEASPRVGGKIQ---TVKKDGYIIE 61 Query: 258 QGLDFKLSTKVISAKRNDDKNVVEIVVEDTKT 289 +G D L K + + D + ++V + Sbjct: 62 RGPDSFLERKKSAPQLVKDLGLEHLLVNNATG 93 >4R16-A nrPDB Length = 418 Score = 32.2 bits (72), Expect = 0.55, Method: Composition-based stats. Identities = 13/77 (16%), Positives = 33/77 (42%) Query: 206 RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLS 265 R+ ++G G IGL +++ G V + + ++ ++ VA + + ++ + Sbjct: 2 RIAVLGLGYIGLPTAIMFASSGYDVVGYDIRSEVIKKINSGVAHIIEPEIDRRLKEVLSL 61 Query: 266 TKVISAKRNDDKNVVEI 282 K+ R +D + Sbjct: 62 GKLKVTDRVEDLKGSNV 78 >3Q9T-A nrPDB Length = 577 Score = 32.2 bits (72), Expect = 0.59, Method: Composition-based stats. Identities = 13/37 (35%), Positives = 16/37 (43%), Gaps = 1/37 (2%) Query: 22 TINKSHDVVIIGGGPAGYVAAIKAAQL-GFNTACVEK 57 T D VI+GGG AG A + A+ VE Sbjct: 2 TDGSHFDFVIVGGGTAGNTVAGRLAENPNVTVLIVEA 38 >4N9X-A nrPDB Length = 411 Score = 31.8 bits (71), Expect = 0.61, Method: Composition-based stats. Identities = 14/37 (37%), Positives = 17/37 (45%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGK 60 +S DVVI GGG G A G A +EK+ Sbjct: 1 MQSFDVVIAGGGMVGLALACGLQGSGLRIAVLEKQAA 37 >4B4O-A nrPDB Length = 298 Score = 31.8 bits (71), Expect = 0.70, Method: Composition-based stats. Identities = 14/45 (31%), Positives = 23/45 (51%), Gaps = 1/45 (2%) Query: 206 RLTIIGG-GIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAK 249 R+ + GG G IG + + + G +VT+V +P G E+A Sbjct: 2 RVLVGGGTGFIGTALTQLLNARGHEVTLVSRKPGPGRITWDELAA 46 >4IIN-A nrPDB Length = 271 Score = 31.8 bits (71), Expect = 0.72, Method: Composition-based stats. Identities = 18/78 (23%), Positives = 33/78 (42%), Gaps = 10/78 (12%) Query: 183 GIEIDEEKIVSSTGALSLKEIPKRLTIIGGGI-IGLEMGSVYSRLGSKVTVVEFQPQIGA 241 G+++ E + + A+ K + I G IG E+ + +G KV + Sbjct: 10 GVDLGTENLYFQSNAMQF--TGKNVLITGASKGIGAEIAKTLASMGLKVWINYRSN---- 63 Query: 242 SMDGEVAKATQKFLKKQG 259 EVA A + L+++G Sbjct: 64 ---AEVADALKNELEEKG 78 >4K22-A nrPDB Length = 365 Score = 31.8 bits (71), Expect = 0.73, Method: Composition-based stats. Identities = 14/61 (22%), Positives = 30/61 (49%), Gaps = 7/61 (11%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQ--PQIGASMDGEVAKAT-----QKFLKKQG 259 + I+GGG++GL + G +V V+E + + A+ ++ + +K L + G Sbjct: 6 VAIVGGGMVGLAVACGLQGSGLRVAVLEQRVQEPLAANAPPQLRVSAINAASEKLLTRLG 65 Query: 260 L 260 + Sbjct: 66 V 66 Score = 31.4 bits (70), Expect = 0.93, Method: Composition-based stats. Identities = 13/35 (37%), Positives = 17/35 (48%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKR 58 +S DV I+GGG G A G A +E+R Sbjct: 1 MQSVDVAIVGGGMVGLAVACGLQGSGLRVAVLEQR 35 >5ZYN-B nrPDB Length = 471 Score = 31.8 bits (71), Expect = 0.75, Method: Composition-based stats. Identities = 10/36 (27%), Positives = 18/36 (50%), Gaps = 1/36 (2%) Query: 29 VVIIGGGPAGYVAAIKA-AQLGFNTACVEKRGKLGG 63 VV+IG G AG + + ++ ++K +GG Sbjct: 7 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG 42 >2IVE-A nrPDB Length = 478 Score = 31.8 bits (71), Expect = 0.78, Method: Composition-based stats. Identities = 14/45 (31%), Positives = 21/45 (46%), Gaps = 4/45 (8%) Query: 19 RTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 RT +N V ++GGG +G A G + +E +LGG Sbjct: 13 RTTGMN----VAVVGGGISGLAVAHHLRSRGTDAVLLESSARLGG 53 Score = 31.4 bits (70), Expect = 0.98, Method: Composition-based stats. Identities = 14/64 (21%), Positives = 30/64 (46%), Gaps = 3/64 (4%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLST 266 + ++GGGI GL + G+ ++E ++G ++ A +L +QG + L Sbjct: 19 VAVVGGGISGLAVAHHLRSRGTDAVLLESSARLGGAVG---THALAGYLVEQGPNSFLDR 75 Query: 267 KVIS 270 + + Sbjct: 76 EPAT 79 >5I68-A nrPDB Length = 663 Score = 31.4 bits (70), Expect = 0.84, Method: Composition-based stats. Identities = 9/39 (23%), Positives = 18/39 (46%), Gaps = 2/39 (5%) Query: 21 LTINKSHDVVIIGGGPAGYVAAIKAA--QLGFNTACVEK 57 + I + D++++GGG +G A + A +E Sbjct: 1 MAIPEEFDILVLGGGSSGSCIAGRLANLDHSLKVGLIEA 39 >4UDQ-A nrPDB Length = 531 Score = 31.4 bits (70), Expect = 0.85, Method: Composition-based stats. Identities = 12/32 (37%), Positives = 17/32 (53%), Gaps = 1/32 (3%) Query: 27 HDVVIIGGGPAGYVAAIK-AAQLGFNTACVEK 57 D VI+GGG AG V A + +A+ +E Sbjct: 6 FDYVIVGGGTAGSVLANRLSARPENRVLLIEA 37 >2QA2-A nrPDB Length = 499 Score = 31.4 bits (70), Expect = 0.89, Method: Composition-based stats. Identities = 21/107 (19%), Positives = 39/107 (36%), Gaps = 6/107 (5%) Query: 206 RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQP-QIGASMDGEVAKATQKFLKKQGLDFKL 264 + ++G G GL + G V V+E P + G S T + ++G+ Sbjct: 14 SVIVVGAGPAGLMLAGELRLGGVDVMVLEQLPQRTGESRGLGFTARTMEVFDQRGILPAF 73 Query: 265 STKVISAKRNDDKNVVEIVVEDTKTNKQENL---EAEVLL--VAVGR 306 S + + V+ V + + + E +L A+GR Sbjct: 74 GPVETSTQGHFGGRPVDFGVLEGAHYGVKAVPQSTTESVLEEWALGR 120 Score = 29.9 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 9/32 (28%), Positives = 18/32 (56%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGK 60 V+++G GPAG + A + G + +E+ + Sbjct: 15 VIVVGAGPAGLMLAGELRLGGVDVMVLEQLPQ 46 >3GG2-A nrPDB Length = 450 Score = 31.4 bits (70), Expect = 0.94, Method: Composition-based stats. Identities = 17/109 (15%), Positives = 45/109 (41%), Gaps = 12/109 (11%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEF-QPQI--GASMDGEVAKATQKFLKKQGLD-- 261 + ++G G +GL + ++ LG+ V ++ + +I S + + + + + + Sbjct: 5 IAVVGIGYVGLVSATCFAELGANVRCIDTDRNKIEQLNSGTIPIYEPGLEKMIARNVKAG 64 Query: 262 -FKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVA---VGR 306 + T++ A D + + T + + + +L A +GR Sbjct: 65 RLRFGTEIEQAVPEADIIFIAV---GTPAGEDGSADMSYVLDAARSIGR 110 >2EEZ-A nrPDB Length = 369 Score = 31.4 bits (70), Expect = 0.94, Method: Composition-based stats. Identities = 10/41 (24%), Positives = 22/41 (53%) Query: 204 PKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMD 244 P + I+GGG +G + +G++VT+++ + +D Sbjct: 166 PASVVILGGGTVGTNAAKIALGMGAQVTILDVNHKRLQYLD 206 >3O31-A nrPDB Length = 296 Score = 31.4 bits (70), Expect = 0.99, Method: Composition-based stats. Identities = 18/79 (22%), Positives = 34/79 (43%), Gaps = 5/79 (6%) Query: 191 IVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKA 250 ++ + AL +R IGGG + L + G +V VVE +P I E+++ Sbjct: 109 LLKNEAALGRFRRGERAVFIGGGPLPLTGILLSHVYGMRVNVVEIEPDI-----AELSRK 163 Query: 251 TQKFLKKQGLDFKLSTKVI 269 + L G++ + + Sbjct: 164 VIEGLGVDGVNVITGDETV 182 >1E3J-A nrPDB Length = 352 Score = 31.4 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 10/26 (38%), Positives = 14/26 (53%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTAC 54 V++IG GP G V+ + A G C Sbjct: 172 VLVIGAGPIGLVSVLAAKAYGAFVVC 197 >1VIM-A nrPDB Length = 200 Score = 31.1 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 20/114 (17%), Positives = 38/114 (33%), Gaps = 14/114 (12%) Query: 196 GALSLKEIPKRLTIIGGG---IIGLEMGSVYSRLGSKVTVVEFQPQIGASM-DGEVAKAT 251 + L + + + +IG G I LG V VV + + D +V Sbjct: 39 EMIKLIDSARSIFVIGAGRSGYIAKAFAMRLMHLGYTVYVV--GETVTPRITDQDVLVGI 96 Query: 252 QKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVG 305 + T V++ + ++V K + A+V++V G Sbjct: 97 SGSGET--------TSVVNISKKAKDIGSKLVAVTGKRDSSLAKMADVVMVVKG 142 >6H3G-A nrPDB Length = 651 Score = 31.1 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 12/32 (37%), Positives = 16/32 (50%), Gaps = 2/32 (6%) Query: 28 DVVIIGGGPAGYVAAIKAAQLG--FNTACVEK 57 DV++ GGGPAG V A + A +E Sbjct: 8 DVIVCGGGPAGCVVAGRLAYADPTLKVMLIEG 39 >4XRR-A nrPDB Length = 456 Score = 31.1 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 8/31 (25%), Positives = 16/31 (51%) Query: 204 PKRLTIIGGGIIGLEMGSVYSRLGSKVTVVE 234 P ++ I G G +G + + G++V V+ Sbjct: 15 PLKVVIAGAGYVGTCLAVTLAGRGAEVVAVD 45 >3RP7-A nrPDB Length = 407 Score = 31.1 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 11/46 (23%), Positives = 18/46 (39%) Query: 16 STVRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKL 61 S+ L ++IG G G AA+ Q G + E ++ Sbjct: 13 SSGENLYFQGHMKAIVIGAGIGGLSAAVALKQSGIDCDVYEAVKEI 58 >2RGJ-A nrPDB Length = 402 Score = 31.1 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 9/40 (22%), Positives = 18/40 (45%), Gaps = 1/40 (2%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGF-NTACVEKRGKL 61 +++ D++I G G G A+ Q G +E ++ Sbjct: 1 MSEPIDILIAGAGIGGLSCALALHQAGIGKVTLLESSSEI 40 >2CDC-A nrPDB Length = 366 Score = 31.1 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 6/33 (18%), Positives = 17/33 (51%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQP 237 +++ ++G G IG+ ++ G +V + + Sbjct: 182 RKVLVVGTGPIGVLFTLLFRTYGLEVWMANRRE 214 >5X68-A nrPDB Length = 391 Score = 31.1 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 8/33 (24%), Positives = 18/33 (54%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQP 237 K++ +IGGG++G ++ ++ V E + Sbjct: 15 KKVAVIGGGLVGSLQACFLAKRNFQIDVYEARE 47 >4U2L-A nrPDB Length = 510 Score = 31.1 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 9/27 (33%), Positives = 15/27 (55%) Query: 30 VIIGGGPAGYVAAIKAAQLGFNTACVE 56 V+IG G V+A++ + G T +E Sbjct: 9 VVIGTGYGAAVSALRLGEAGVQTLMLE 35 >1XJ5-A nrPDB Length = 334 Score = 31.1 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 20/136 (14%), Positives = 52/136 (38%), Gaps = 20/136 (14%) Query: 166 DVKNIIV---ATGSEVTPFPGI-------EIDEEKIVSSTGALSLKEIPKRLTIIGGGII 215 D +++IV AT +V G+ E +++++ S+ PK++ +IGGG Sbjct: 74 DYQDVIVFQSATYGKVLVLDGVIQLTERDECAYQEMITHLPLCSIP-NPKKVLVIGGGD- 131 Query: 216 GLEMGSVYSRLGSKVTV----VEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTKVISA 271 G V + ++ + ++ + + + ++ + V Sbjct: 132 ----GGVLREVARHASIEQIDMCEIDKMVVDVSKQFFPDVAIGYEDPRVNLVIGDGVAFL 187 Query: 272 KRNDDKNVVEIVVEDT 287 K + + ++V+ + Sbjct: 188 KNAAEGSYDAVIVDSS 203 >3TF5-A nrPDB Length = 493 Score = 30.7 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 29/161 (18%), Positives = 55/161 (34%), Gaps = 26/161 (16%) Query: 205 KRLTIIGGGIIGLEMGSVYSRL--GSKVTVVEFQPQIGASMDGEVAKATQKFLKK----- 257 K++ IG G +G SV + + +VTVV+ + + + LK+ Sbjct: 5 KKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLPIYEPGLKEVVESC 64 Query: 258 QGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEK 317 +G + ST + A + D + + TKT + GR + + A Sbjct: 65 RGKNLFFSTNIDDAIKEADLVFISVN-TPTKTYG----------MGKGRAADLKYIEACA 113 Query: 318 IGLEVDKRGRLVIDDQF-----NSKFPHIKVVGDVTFGPML 353 + + G ++ ++ I D P L Sbjct: 114 RRIVQNSNGYKIVTEKSTPVRAAESIRRIF---DANTKPNL 151 >6C87-A nrPDB Length = 452 Score = 30.7 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 29/158 (18%), Positives = 55/158 (34%), Gaps = 22/158 (13%) Query: 23 INKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHL 82 +N+ +DVV++G G V + + G +++ GG A LN + Sbjct: 9 MNEEYDVVVLGTGLTECVISGLLSVSGKKVLHMDRNPYYGG---------ESASLNLDQM 59 Query: 83 FHQMH----TEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGN 138 F + G + +I + + F A VK L + + + Sbjct: 60 FEKFRGQDAKPPASLGRSRDYNIDL-IPKFLMANGKLVKILR---MTGVTRYNMEFALVE 115 Query: 139 GSFEDE----TKIRVTPVDGLEGT-VKEDHILDVKNII 171 GSF K+ +TP + + + L K ++ Sbjct: 116 GSFVYHKGEIHKVPITPTEVAKTPLLGFFEKLKAKKLV 153 >5NCC-A nrPDB Length = 594 Score = 30.7 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 9/31 (29%), Positives = 16/31 (51%) Query: 25 KSHDVVIIGGGPAGYVAAIKAAQLGFNTACV 55 + +D +++GGG A V A + + G V Sbjct: 22 QKYDYILVGGGTAACVLANRLSADGSKRVLV 52 >3KKJ-A nrPDB Length = 336 Score = 30.7 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 14/35 (40%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 + IIG G AG AA G +K GG Sbjct: 5 IAIIGTGIAGLSAAQALTAAGHQVHLFDKSRGSGG 39 Score = 29.9 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 9/28 (32%), Positives = 14/28 (50%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVE 234 + IIG GI GL + G +V + + Sbjct: 5 IAIIGTGIAGLSAAQALTAAGHQVHLFD 32 >2B76-A nrPDB Length = 602 Score = 30.7 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 4/22 (18%), Positives = 9/22 (40%) Query: 326 GRLVIDDQFNSKFPHIKVVGDV 347 G + D ++ + VG+ Sbjct: 360 GGIETDQNCETRIKGLFAVGEC 381 >2WTB-A nrPDB Length = 725 Score = 30.3 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 16/105 (15%), Positives = 39/105 (37%), Gaps = 13/105 (12%) Query: 200 LKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQG 259 + K++ IIGGG++G + + V + E + + G V Q Sbjct: 308 VPRKIKKVAIIGGGLMGSGIATALILSNYPVILKEVNEKFLEAGIGRVKANLQ------- 360 Query: 260 LDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAV 304 ++V + +K + + + + + ++++ AV Sbjct: 361 ------SRVRKGSMSQEKFEKTMSLLKGSLDYESFRDVDMVIEAV 399 >3K6J-A nrPDB Length = 460 Score = 30.3 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 14/37 (37%), Positives = 18/37 (48%), Gaps = 3/37 (8%) Query: 22 TINKSHDV---VIIGGGPAGYVAAIKAAQLGFNTACV 55 T ++++DV IIGGG G AI G T V Sbjct: 47 TNSEAYDVNSVAIIGGGTMGKAMAICFGLAGIETFLV 83 >3BA1-A nrPDB Length = 333 Score = 30.3 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 28/140 (20%), Positives = 48/140 (34%), Gaps = 25/140 (17%) Query: 201 KEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGL 260 K KR+ IIG G IGL V E + D ++ ++ KK Sbjct: 161 KFSGKRVGIIGLGRIGL-------------AVAERAE----AFDCPISYFSRS--KKPNT 201 Query: 261 DFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLEAE-----VLLVAVGRRPYIAGLGA 315 ++ V+ N D VV + T+ + +L+ +GR P++ Sbjct: 202 NYTYYGSVVELASNSDILVVACPLTPETTHIINREVIDALGPKGVLINIGRGPHVDEPEL 261 Query: 316 EKIGLEVDKRGRLVIDDQFN 335 +E + G +D Sbjct: 262 VSALVE-GRLGGAGLDVFER 280 >1VE9-A nrPDB Length = 347 Score = 30.3 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 14/54 (25%), Positives = 19/54 (35%), Gaps = 12/54 (22%) Query: 206 RLTIIGGGIIGLEMG--------SVYSRLGSKVTVVEFQPQIGASMDGEVAKAT 251 R+ +IG G+IGL SV L KV + +VA Sbjct: 2 RVVVIGAGVIGLSTALCIHERYHSVLQPLDVKVY----ADRFTPFTTTDVAAGL 51 >5W1A-A nrPDB Length = 810 Score = 30.3 bits (67), Expect = 2.2, Method: Composition-based stats. Identities = 27/113 (23%), Positives = 40/113 (35%), Gaps = 12/113 (10%) Query: 339 PHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMYSHPEVAWVGKTEE 398 PHI + D + ML + + + E N V+ V KT+E Sbjct: 153 PHIFAISDGAYVDMLTNHVNQSMLITGESGAGK-----TENTKKVIAYFATVGASKKTDE 207 Query: 399 QLKEAG--IDYKIGKFP-FAANSRAKT--NQDTEGFVKILID--SKTERILGA 444 K G D + P A AKT N ++ F K + T ++ GA Sbjct: 208 AAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGA 260 >4Z25-A nrPDB Length = 652 Score = 30.3 bits (67), Expect = 2.2, Method: Composition-based stats. Identities = 11/31 (35%), Positives = 15/31 (48%), Gaps = 1/31 (3%) Query: 28 DVVIIGGGPAGYVAAIKAAQ-LGFNTACVEK 57 D+VIIG G AG + A A+ +E Sbjct: 8 DIVIIGAGAAGSLLAHYLARFSNMKIILLEA 38 >3CUK-A nrPDB Length = 347 Score = 30.3 bits (67), Expect = 2.2, Method: Composition-based stats. Identities = 14/54 (25%), Positives = 19/54 (35%), Gaps = 12/54 (22%) Query: 206 RLTIIGGGIIGLEMG--------SVYSRLGSKVTVVEFQPQIGASMDGEVAKAT 251 R+ +IG G+IGL SV L KV + +VA Sbjct: 2 RVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVY----ADRFTPLTTTDVAAGL 51 >4Z44-A nrPDB Length = 554 Score = 30.3 bits (67), Expect = 2.2, Method: Composition-based stats. Identities = 13/32 (40%), Positives = 20/32 (62%), Gaps = 3/32 (9%) Query: 29 VVIIGGGPAGYVAA---IKAAQLGFNTACVEK 57 +VI+GGG AG++AA ++A Q N +E Sbjct: 24 IVIVGGGTAGWMAASYLVRALQQQANITLIES 55 >3F3S-A nrPDB Length = 313 Score = 30.3 bits (67), Expect = 2.2, Method: Composition-based stats. Identities = 12/53 (22%), Positives = 26/53 (49%), Gaps = 1/53 (1%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQG 259 + I+G G+IG +++ G +V + + + Q + + K K L++ G Sbjct: 6 VVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEM-KLLEQAG 57 >4ZCC-A nrPDB Length = 336 Score = 30.3 bits (67), Expect = 2.3, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 14/35 (40%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 + IIG G AG AA G +K GG Sbjct: 5 IAIIGTGIAGLSAAQALTSAGHQVHLFDKSRGSGG 39 Score = 29.9 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 9/28 (32%), Positives = 14/28 (50%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVE 234 + IIG GI GL + G +V + + Sbjct: 5 IAIIGTGIAGLSAAQALTSAGHQVHLFD 32 >3GFZ-A nrPDB Length = 413 Score = 29.9 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 15/104 (14%), Positives = 35/104 (33%), Gaps = 8/104 (7%) Query: 171 IVATGSEVTPFPGIEIDEEKIVSSTGAL-----SLKEIPKRLTI--IGGGIIGLEMGSVY 223 ++A G IE+ E ++++ +L+ +L I G G GL + + + Sbjct: 267 LLAAGLRPDQVL-IEVTETEVITCFDQFRKVLKALRVAGMKLAIDDFGAGYSGLSLLTRF 325 Query: 224 SRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLSTK 267 KV + + + + + + G+ Sbjct: 326 QPDKIKVDAELVRDIHISGTKQAIVASVVRCCEDLGITVVAEGV 369 >5L46-A nrPDB Length = 841 Score = 29.9 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 21/85 (24%), Positives = 33/85 (38%), Gaps = 11/85 (12%) Query: 30 VIIGGGPAGYVAAIKAAQLGFN-TACVEKRGKLGGTCLNVGCI-----P----SKALLNN 79 VIIGGG G A A+ G +EK G+ + + P K ++ Sbjct: 26 VIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDS 85 Query: 80 SHLFHQMHTE-AQKRGIDVNGDIKI 103 L+ ++ E Q G G I++ Sbjct: 86 IKLYEKLEEETGQVVGFHQPGSIRL 110 >5XMJ-A nrPDB Length = 627 Score = 29.9 bits (66), Expect = 2.6, Method: Composition-based stats. Identities = 11/30 (36%), Positives = 16/30 (53%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACV 55 DV+ IGG AG A++A+ G T + Sbjct: 5 HTDVLCIGGALAGERVAVEASMAGLKTIML 34 >4X4J-A nrPDB Length = 507 Score = 29.9 bits (66), Expect = 2.6, Method: Composition-based stats. Identities = 18/91 (19%), Positives = 32/91 (35%), Gaps = 1/91 (1%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQP-QIGASMDGEVAKATQKFLKKQGLDFKLS 265 + I G G GL + G V V+E P + G S T + ++GL + Sbjct: 25 VVIAGAGPAGLMLAGELRLAGIGVVVLERLPARTGESRGLGFTARTMEVFDQRGLLRRFG 84 Query: 266 TKVISAKRNDDKNVVEIVVEDTKTNKQENLE 296 S + + V+ + D + + Sbjct: 85 EVQTSDQGHFGGIPVDFGLLDGAHQAAKTIP 115 Score = 29.1 bits (64), Expect = 4.9, Method: Composition-based stats. Identities = 11/32 (34%), Positives = 15/32 (46%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVEKRGK 60 VVI G GPAG + A + G +E+ Sbjct: 25 VVIAGAGPAGLMLAGELRLAGIGVVVLERLPA 56 >3IFR-A nrPDB Length = 508 Score = 29.9 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 33/203 (16%), Positives = 71/203 (34%), Gaps = 22/203 (10%) Query: 44 KAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLN--NSHLFHQMHTEAQKRGIDVNGDI 101 +A T E + GG C+ G +P+ LL+ + L + + G +V ++ Sbjct: 60 RAVLAELKTTAGESDWRPGGICV-TGMLPAVVLLDDRGAVLRPSIQQSDGRCGDEV-AEL 117 Query: 102 KINVAN---FQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGT 158 + V + + + +QL ++++ + + + + E Sbjct: 118 RAEVDSEAFLARTGNGVTQQLVTAKLRWIERHEPAVFGAIATVCGSYDY-INMLLTGERV 176 Query: 159 VKEDHILDVKNIIVATG---------SEVTP---FPGIEIDEEKIVSSTGALSLKEIPKR 206 V + L+ I +A+G + + P P + A +L +P Sbjct: 177 VDRNWALEGGFIDLASGTVEADLVALAHIPPSAVPPAHPTHRVLGAVTAEAAALTGLPTG 236 Query: 207 LTIIGGGI--IGLEMGSVYSRLG 227 L + GG I + + +R G Sbjct: 237 LPVYGGAADHIASALAAGITRPG 259 >3LLV-A nrPDB Length = 141 Score = 29.9 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 9/37 (24%), Positives = 16/37 (43%) Query: 21 LTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEK 57 +T N ++ ++IG AG + G V+K Sbjct: 1 MTENGRYEYIVIGSEAAGVGLVRELTAAGKKVLAVDK 37 >1XFD-A nrPDB Length = 723 Score = 29.9 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 17/62 (27%), Positives = 24/62 (38%), Gaps = 5/62 (8%) Query: 430 VKILIDSKTERILGAHIIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEAN 489 K+ + +ER LG H + A EM +A A E + HPT E + Sbjct: 619 FKLYASAFSERYLGLHGLDNRAYEMTK---VAHRVSALEEQ--QFLIIHPTADEKIHFQH 673 Query: 490 MA 491 A Sbjct: 674 TA 675 >4P9S-A nrPDB Length = 848 Score = 29.9 bits (66), Expect = 2.9, Method: Composition-based stats. Identities = 32/160 (20%), Positives = 58/160 (36%), Gaps = 17/160 (10%) Query: 30 VIIGGGPAGYVAAIKAAQLGFN-TACVEKRGKLGGTCLNVGCI-----P----SKALLNN 79 VIIGGG G A A+ G +EK G+ + + P K ++ Sbjct: 27 VIIGGGCVGVSLAYHLAKAGMRDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDS 86 Query: 80 SHLFHQMHTE-AQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGN 138 L+ ++ E Q G G I++ A + D+ Q+T ++ + K + Sbjct: 87 IKLYERLEEETGQVVGFHQPGSIRL--ATTPERVDEFKYQMTRTNWHATEQYIIEPEKIH 144 Query: 139 GSFEDETKIRVTPVDGLEGTVKEDHILDVK-NIIVATGSE 177 F + + + + HI + +ATG+ Sbjct: 145 ELF---PLLNMDKILAGLYNPGDGHIDPYSLTMALATGAR 181 >2CUL-A nrPDB Length = 232 Score = 29.5 bits (65), Expect = 3.3, Method: Composition-based stats. Identities = 7/27 (25%), Positives = 14/27 (51%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVV 233 + I+G G G E ++ G +V ++ Sbjct: 6 VLIVGAGFSGAETAFWLAQKGVRVGLL 32 Score = 28.4 bits (62), Expect = 7.5, Method: Composition-based stats. Identities = 9/32 (28%), Positives = 15/32 (46%) Query: 24 NKSHDVVIIGGGPAGYVAAIKAAQLGFNTACV 55 ++ V+I+G G +G A AQ G + Sbjct: 1 MAAYQVLIVGAGFSGAETAFWLAQKGVRVGLL 32 >1QYD-A nrPDB Length = 313 Score = 29.5 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 13/41 (31%), Positives = 24/41 (58%), Gaps = 2/41 (4%) Query: 206 RLTIIGG-GIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDG 245 R+ I+GG G IG + + LG V+ F+P++ +++D Sbjct: 6 RVLIVGGTGYIGKRIVNASISLGHPTYVL-FRPEVVSNIDK 45 >5EB4-A nrPDB Length = 532 Score = 29.5 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 9/32 (28%), Positives = 18/32 (56%), Gaps = 1/32 (3%) Query: 26 SHDVVIIGGGPAGYVAAIKAAQLGFNTACVEK 57 S+D ++IGGG +G A ++ + +E+ Sbjct: 26 SYDYIVIGGGTSGCPLAATLSEK-YKVLLLER 56 >4DS7-A nrPDB Length = 147 Score = 29.5 bits (65), Expect = 3.5, Method: Composition-based stats. Identities = 22/125 (17%), Positives = 40/125 (32%), Gaps = 15/125 (12%) Query: 185 EIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMD 244 + EE+I A +L + G I E+ +V LG + E + +D Sbjct: 4 NLTEEQIAEFKEAFALFDKDNS-----GSISASELATVMRSLGLSPSEAEVAD-LMNEID 57 Query: 245 ---------GEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENL 295 E + LK + +L +N D + ++ T+ E L Sbjct: 58 VDGNHAIEFSEFLALMSRQLKCNDSEQELLEAFKVFDKNGDGLISAAELKHVLTSIGEKL 117 Query: 296 EAEVL 300 + Sbjct: 118 TDAEV 122 >3OJO-A nrPDB Length = 431 Score = 29.5 bits (65), Expect = 3.6, Method: Composition-based stats. Identities = 9/25 (36%), Positives = 16/25 (64%) Query: 206 RLTIIGGGIIGLEMGSVYSRLGSKV 230 +LT++G G IGL ++++ G V Sbjct: 13 KLTVVGLGYIGLPTSIMFAKHGVDV 37 >4CJX-A nrPDB Length = 319 Score = 29.5 bits (65), Expect = 3.6, Method: Composition-based stats. Identities = 12/43 (27%), Positives = 21/43 (48%), Gaps = 1/43 (2%) Query: 203 IPKRLTIIGGGII-GLEMGSVYSRLGSKVTVVEFQPQIGASMD 244 KR+ ++G G I GL + ++ + + VTVV + D Sbjct: 183 CGKRVVVLGRGDIAGLPVATLLANEDATVTVVHSATPLCDIAD 225 >4G65-A nrPDB Length = 461 Score = 29.5 bits (65), Expect = 3.6, Method: Composition-based stats. Identities = 22/139 (15%), Positives = 51/139 (36%), Gaps = 22/139 (15%) Query: 196 GALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFL 255 L++ +R+ I+GGG IG + + V ++E + A+ + L Sbjct: 227 ELQRLEKPYRRIMIVGGGNIGASLAKRLEQT-YSVKLIERN--------LQRAEKLSEEL 277 Query: 256 KKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQEN----------LEAEVLLVAVG 305 + + ++N+ ++ V TN+ E + A+ ++V + Sbjct: 278 EN---TIVFCGDAADQELLTEENIDQVDVFIALTNEDETNIMSAMLAKRMGAKKVMVLIQ 334 Query: 306 RRPYIAGLGAEKIGLEVDK 324 R Y+ + I + + Sbjct: 335 RGAYVDLVQGGVIDVAISP 353 >6D9T-A nrPDB Length = 400 Score = 29.5 bits (65), Expect = 3.7, Method: Composition-based stats. Identities = 16/80 (20%), Positives = 30/80 (37%), Gaps = 6/80 (7%) Query: 211 GGGIIGLEMGSVYSRLGSKVTVV-----EFQPQIGASMD-GEVAKATQKFLKKQGLDFKL 264 G GII E+G + G +V + + +M +V + D L Sbjct: 33 GSGIIATELGIKLAERGHEVHFITSNIPFRIRKPLPNMIFHQVEVNQYAVFQYPPYDITL 92 Query: 265 STKVISAKRNDDKNVVEIVV 284 STK+ + D +++ + Sbjct: 93 STKIAEVIKEYDLDLLHMHY 112 >1CLM-A nrPDB Length = 148 Score = 29.5 bits (65), Expect = 3.8, Method: Composition-based stats. Identities = 27/124 (21%), Positives = 46/124 (37%), Gaps = 13/124 (10%) Query: 185 EIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQI----- 239 E+ EE+I A +L + TI E+G+V LG T E Q I Sbjct: 3 ELTEEQIAEFKEAFALFDKDGDGTI-----TTKELGTVMRSLGQNPTEAELQDMINEVDA 57 Query: 240 --GASMD-GEVAKATQKFLKKQGLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENLE 296 ++D E + +K+Q + +L R+ + + + TN E L Sbjct: 58 DGNGTIDFPEFLSLMARKMKEQDSEEELIEAFKVFDRDGNGLISAAELRHVMTNLGEKLT 117 Query: 297 AEVL 300 + + Sbjct: 118 DDEV 121 >3P1W-A nrPDB Length = 475 Score = 29.5 bits (65), Expect = 3.9, Method: Composition-based stats. Identities = 8/39 (20%), Positives = 18/39 (46%) Query: 25 KSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGG 63 + +DV+I+G G + + + G +++ GG Sbjct: 19 EHYDVIILGTGLKECILSGLLSHYGKKILVLDRNPYYGG 57 >2BK5-A nrPDB Length = 520 Score = 29.1 bits (64), Expect = 4.1, Method: Composition-based stats. Identities = 9/26 (34%), Positives = 12/26 (46%) Query: 38 GYVAAIKAAQLGFNTACVEKRGKLGG 63 G AA G N +E R ++GG Sbjct: 16 GMAAAKLLHDSGLNVVVLEARDRVGG 41 >6H65-A nrPDB Length = 317 Score = 29.1 bits (64), Expect = 4.2, Method: Composition-based stats. Identities = 30/185 (16%), Positives = 61/185 (32%), Gaps = 27/185 (14%) Query: 66 LNVGCIPSKALLNNSHLFHQMHTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIEL 125 +N CIP + L + T+A G + ++ + + V +L + Sbjct: 18 MNGQCIP----WDQCSL--HVSTQAAFFGASLFEGVRAYWNA--EREQLYVFRLDEHLRR 69 Query: 126 LFKKNKVTYYKGNGSFEDETKIRVTPVDGLEGTVKEDHILDVKNI--------------- 170 L + K+ K + D + V + + H+ Sbjct: 70 LEQSAKMLRMKLSMPIADIRQ-GVLELLRANEFRSDVHLYVASYFGINHDPDPLFPTDDT 128 Query: 171 -IVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKRLTIIGGGIIGLEMGSVYSRL-GS 228 + TG+ V+ P + +SS +S +P R+ IG + +R+ G Sbjct: 129 GVYVTGTAVSRLPLVHTGISACMSSWRRISDDSVPPRIK-IGANYQNSRLAQTEARVNGY 187 Query: 229 KVTVV 233 +V+ Sbjct: 188 HTSVL 192 >2Y0D-A nrPDB Length = 478 Score = 29.1 bits (64), Expect = 4.3, Method: Composition-based stats. Identities = 28/141 (19%), Positives = 50/141 (35%), Gaps = 13/141 (9%) Query: 29 VVIIGGGPAGYVAAIKAAQLGFNTACVE-KRGKLGGTCLNVGCIPSKALLNNSHLFHQMH 87 + IIG G G V A +G + C++ + K+ LN G +P ++ L + Sbjct: 11 LTIIGSGKVGLVTGACLADIGHDVFCLDVDQAKI--DILNNGGVP----IHEPGLKEVIA 64 Query: 88 TEAQKRGIDVNGDIKINVANF------QKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSF 141 + + DI+ VA+ D L +N Y G Sbjct: 65 RNRSAGRLRFSTDIEAAVAHGDVQFIAVGTPPDEDGSADLQYVLAAARNIGRYMTGFKVI 124 Query: 142 EDETKIRVTPVDGLEGTVKED 162 D++ + V + + V E+ Sbjct: 125 VDKSTVPVGTAERVRAAVAEE 145 Score = 28.0 bits (61), Expect = 8.8, Method: Composition-based stats. Identities = 23/106 (21%), Positives = 35/106 (33%), Gaps = 16/106 (15%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLST 266 LTIIG G +GL G+ + +G V +V +A L G+ Sbjct: 11 LTIIGSGKVGLVTGACLADIGHDV------------FCLDVDQAKIDILNNGGVPIHEPG 58 Query: 267 KVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAG 312 RN + + + +V +AVG P G Sbjct: 59 LKEVIARNRSAGRLRF----STDIEAAVAHGDVQFIAVGTPPDEDG 100 >3IP1-A nrPDB Length = 404 Score = 29.1 bits (64), Expect = 4.6, Method: Composition-based stats. Identities = 17/97 (17%), Positives = 35/97 (36%), Gaps = 9/97 (9%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLST 266 + I+GGG IGL ++ G+ ++ S EV + K L + Sbjct: 217 VVILGGGPIGLAAVAILKHAGA--------SKVILSEPSEVRRNLAKELGADHVIDPTKE 268 Query: 267 K-VISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLV 302 V + + ++ +E T + + E ++ Sbjct: 269 NFVEAVLDYTNGLGAKLFLEATGVPQLVWPQIEEVIW 305 >2AP9-A nrPDB Length = 299 Score = 29.1 bits (64), Expect = 4.6, Method: Composition-based stats. Identities = 22/133 (16%), Positives = 45/133 (33%), Gaps = 28/133 (21%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSK--------VTVVEFQPQIGASMDGEVAKATQKFLKKQ 258 + + GGG ++ ++ RLG + VT E + G+V + + Sbjct: 61 VVVHGGGP---QITAMLRRLGIEGDFKGGFRVTTPEVLDVARMVLFGQVGRELVNLINAH 117 Query: 259 GLDFKLSTKVISAKRNDDKNVVEIVVEDTKTNKQENL----EAEVL-------LVAVGRR 307 G + D + + T ++ + + + LVA GR Sbjct: 118 GPY------AVGITGEDAQLFTAVRRSVTVDGVATDIGLVGDVDQVNTAAMLDLVAAGRI 171 Query: 308 PYIAGLGAEKIGL 320 P ++ L + G+ Sbjct: 172 PVVSTLAPDADGV 184 >4KUG-A nrPDB Length = 290 Score = 28.7 bits (63), Expect = 5.2, Method: Composition-based stats. Identities = 10/57 (17%), Positives = 27/57 (47%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLD 261 K++ ++G G +G + ++ G +V V + + + + K+ K + K+ + Sbjct: 2 KKVFVLGAGTMGAGIVQAFAAKGCEVIVRDIKEEFVDRGIATITKSLSKLVAKEKIT 58 >3MOG-A nrPDB Length = 483 Score = 28.7 bits (63), Expect = 5.6, Method: Composition-based stats. Identities = 16/99 (16%), Positives = 40/99 (40%), Gaps = 13/99 (13%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKL 264 + + +IG G +G + V + G +V + + A+A + + G+ +L Sbjct: 6 QTVAVIGSGTMGAGIAEVAASHGHQVLLYDIS-----------AEALTRAID--GIHARL 52 Query: 265 STKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVA 303 +++V K + + T+ A++++ A Sbjct: 53 NSRVTRGKLTAETCERTLKRLIPVTDIHALAAADLVIEA 91 >2PA3-A nrPDB Length = 410 Score = 28.7 bits (63), Expect = 5.7, Method: Composition-based stats. Identities = 16/62 (25%), Positives = 27/62 (43%), Gaps = 1/62 (1%) Query: 179 TPFPGIEIDEEKIVSST-GALSLKEIPKRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQP 237 P + V + A S + K+L IIG G IG ++G + LG V + + Sbjct: 125 RGVPEANAKAHRGVWNKLAAGSFEARGKKLGIIGYGHIGTQLGILAESLGMYVYFYDIEN 184 Query: 238 QI 239 ++ Sbjct: 185 KL 186 >2YFK-A nrPDB Length = 418 Score = 28.7 bits (63), Expect = 6.1, Method: Composition-based stats. Identities = 19/98 (19%), Positives = 38/98 (38%), Gaps = 9/98 (9%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGC---IPSKALLNNSHLFH 84 D + IG G A ++ Q G+ +E+R L +N+ C P++A+ + HL H Sbjct: 123 DDMYIGKGNAYMHEVSESVQEGYKDGVLEQRPTL----VNLQCDIDHPTQAMADALHLIH 178 Query: 85 QM--HTEAQKRGIDVNGDIKINVANFQKAKDDAVKQLT 120 + + + + + + V +T Sbjct: 179 EFGGIENLKGKKVAMTWAYSPSYGKPLSVPQGIVGLMT 216 >4A7P-A nrPDB Length = 446 Score = 28.7 bits (63), Expect = 6.2, Method: Composition-based stats. Identities = 20/100 (20%), Positives = 37/100 (37%), Gaps = 16/100 (16%) Query: 206 RLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKLS 265 R+ +IG G +GL G+ +S G +V V D + K + L + + Sbjct: 10 RIAMIGTGYVGLVSGACFSDFGHEVVCV----------DKDARKI--ELLHQNVMPIYEP 57 Query: 266 TKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVG 305 N + + + K +A+ + +AVG Sbjct: 58 GLDALVASNVKAGRLSFTTDLAEGVK----DADAVFIAVG 93 >3KYD-B nrPDB Length = 551 Score = 28.7 bits (63), Expect = 6.4, Method: Composition-based stats. Identities = 6/15 (40%), Positives = 10/15 (66%) Query: 205 KRLTIIGGGIIGLEM 219 R+ ++G G IG E+ Sbjct: 20 GRVLVVGAGGIGCEL 34 >3KYC-B nrPDB Length = 660 Score = 28.7 bits (63), Expect = 6.4, Method: Composition-based stats. Identities = 6/15 (40%), Positives = 10/15 (66%) Query: 205 KRLTIIGGGIIGLEM 219 R+ ++G G IG E+ Sbjct: 38 GRVLVVGAGGIGCEL 52 >4EIQ-A nrPDB Length = 549 Score = 28.7 bits (63), Expect = 6.5, Method: Composition-based stats. Identities = 11/30 (36%), Positives = 15/30 (50%) Query: 28 DVVIIGGGPAGYVAAIKAAQLGFNTACVEK 57 DV+I+GGGP G A+ A V+ Sbjct: 28 DVLILGGGPVGMALALDLAHRQVGHLVVDA 57 >1LTH-T nrPDB Length = 319 Score = 28.7 bits (63), Expect = 6.5, Method: Composition-based stats. Identities = 12/34 (35%), Positives = 14/34 (41%) Query: 22 TINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACV 55 T K + +IG G G A AAQ G V Sbjct: 3 TTVKPTKLAVIGAGAVGSTLAFAAAQRGIAREIV 36 >3RED-A nrPDB Length = 521 Score = 28.4 bits (62), Expect = 7.6, Method: Composition-based stats. Identities = 12/45 (26%), Positives = 23/45 (51%), Gaps = 1/45 (2%) Query: 13 AFSSTVRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEK 57 +F+ L + S+D VI+GGG +G A ++ + +E+ Sbjct: 13 SFAYDATDLELEGSYDYVIVGGGTSGCPLAATLSEK-YKVLVLER 56 >3GDN-A nrPDB Length = 521 Score = 28.4 bits (62), Expect = 7.8, Method: Composition-based stats. Identities = 12/45 (26%), Positives = 23/45 (51%), Gaps = 1/45 (2%) Query: 13 AFSSTVRTLTINKSHDVVIIGGGPAGYVAAIKAAQLGFNTACVEK 57 +F+ L + S+D VI+GGG +G A ++ + +E+ Sbjct: 13 SFAYDATDLELEGSYDYVIVGGGTSGCPLAATLSEK-YKVLVLER 56 >4D3F-A nrPDB Length = 310 Score = 28.4 bits (62), Expect = 7.9, Method: Composition-based stats. Identities = 16/45 (35%), Positives = 21/45 (46%), Gaps = 3/45 (6%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAK 249 K +T+IG G +G M V+ G VTV + D VAK Sbjct: 22 KSVTVIGLGPMGQAMADVFLEYGYSVTVWNRTS---SKADQLVAK 63 >2RIR-A nrPDB Length = 300 Score = 28.0 bits (61), Expect = 9.0, Method: Composition-based stats. Identities = 12/68 (17%), Positives = 26/68 (38%), Gaps = 3/68 (4%) Query: 207 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGE-VAKATQKFLKKQ--GLDFK 263 + ++G G G+ + ++ LG+ V V A + + LK+ +D Sbjct: 160 VAVLGLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDIC 219 Query: 264 LSTKVISA 271 ++T Sbjct: 220 INTIPSMI 227 >2DQ4-A nrPDB Length = 343 Score = 28.0 bits (61), Expect = 9.8, Method: Composition-based stats. Identities = 13/68 (19%), Positives = 21/68 (30%) Query: 205 KRLTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGASMDGEVAKATQKFLKKQGLDFKL 264 K + I G G IGL V G+ +V + A L++ L+ Sbjct: 166 KSVLITGAGPIGLMAAMVVRASGAGPILVSDPNPYRLAFARPYADRLVNPLEEDLLEVVR 225 Query: 265 STKVISAK 272 + Sbjct: 226 RVTGSGVE 233 >3HM2-A nrPDB Length = 178 Score = 28.0 bits (61), Expect = 9.8, Method: Composition-based stats. Identities = 18/51 (35%), Positives = 22/51 (43%), Gaps = 14/51 (27%) Query: 28 DVVIIGGG---PAGYVAAIK----AAQLGFNTACVEK-------RGKLGGT 64 DV+ IGGG P + AA K +L N VE R + GGT Sbjct: 96 DVIFIGGGLTAPGVFAAAWKRLPVGGRLVANAVTVESEQMLWALRKQFGGT 146 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.314 0.147 0.402 Lambda K H 0.267 0.0449 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 19,637,854 Number of Sequences: 36641 Number of extensions: 890908 Number of successful extensions: 5398 Number of sequences better than 10.0: 382 Number of HSP's better than 10.0 without gapping: 436 Number of HSP's successfully gapped in prelim test: 138 Number of HSP's that attempted gapping in prelim test: 3543 Number of HSP's gapped (non-prelim): 1046 length of query: 499 length of database: 10,336,785 effective HSP length: 101 effective length of query: 398 effective length of database: 6,636,044 effective search space: 2641145512 effective search space used: 2641145512 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 62 (28.4 bits)