BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P09622 (509 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 5J5Z-A nrPDB 962 0.0 1V59-A nrPDB 538 e-153 1DXL-A nrPDB 533 e-152 3URH-A nrPDB 516 e-146 2QAE-A nrPDB 468 e-132 5TR3-A nrPDB 448 e-126 5U8W-A nrPDB 443 e-124 3LAD-A nrPDB 439 e-123 6AON-A nrPDB 416 e-116 2YQU-A nrPDB 412 e-115 6BZ0-A nrPDB 395 e-110 1EBD-A nrPDB 359 2e-99 2EQ6-A nrPDB 350 7e-97 4JDR-A nrPDB 345 3e-95 6CMZ-A nrPDB 271 3e-73 1LVL-A nrPDB 270 1e-72 3II4-A nrPDB 261 5e-70 5U25-A nrPDB 255 3e-68 1OJT-A nrPDB 250 8e-67 5X1Y-B nrPDB 230 1e-60 4YWO-A nrPDB 184 6e-47 1ZK7-A nrPDB 184 8e-47 4KPR-E nrPDB 181 8e-46 1GEU-A nrPDB 174 6e-44 2CFY-A nrPDB 174 1e-43 2R9Z-A nrPDB 171 6e-43 2WOV-A nrPDB 164 1e-40 1ZDL-A nrPDB 164 1e-40 6B4O-A nrPDB 164 1e-40 2AAQ-A nrPDB 163 1e-40 1FEC-A nrPDB 162 4e-40 2X8H-A nrPDB 161 5e-40 2YAU-A nrPDB 157 1e-38 3L8K-A nrPDB 155 5e-38 6N7F-A nrPDB 154 1e-37 6DU7-A nrPDB 153 2e-37 4LA1-A nrPDB 153 2e-37 2HQM-A nrPDB 152 4e-37 2NVK-X nrPDB 151 6e-37 5W1J-A nrPDB 150 1e-36 5VDN-A nrPDB 150 2e-36 4B1B-A nrPDB 147 8e-36 4DNA-A nrPDB 147 1e-35 3IC9-A nrPDB 143 2e-34 3O0H-A nrPDB 142 3e-34 4NEW-A nrPDB 141 8e-34 1XDI-A nrPDB 134 1e-31 5U1O-A nrPDB 132 3e-31 5V36-A nrPDB 130 1e-30 1ONF-A nrPDB 117 1e-26 3Q6J-A nrPDB 107 1e-23 5JCN-A nrPDB 63 3e-10 3ICS-A nrPDB 61 1e-09 4GCM-A nrPDB 61 1e-09 3IWA-A nrPDB 60 2e-09 1YQZ-A nrPDB 59 4e-09 2BC1-A nrPDB 57 1e-08 5ER0-A nrPDB 57 2e-08 1NHQ-A nrPDB 56 3e-08 3NTA-A nrPDB 56 4e-08 3CGD-A nrPDB 55 1e-07 3OC4-A nrPDB 52 7e-07 2A87-A nrPDB 50 2e-06 2CDU-A nrPDB 43 3e-04 4EMJ-A nrPDB 43 4e-04 3FG2-P nrPDB 42 6e-04 2V3B-A nrPDB 41 0.001 2YVG-A nrPDB 41 0.001 3AB1-A nrPDB 40 0.002 1Q1R-A nrPDB 40 0.003 4FX9-A nrPDB 39 0.004 2Q7V-A nrPDB 39 0.005 5JFC-L nrPDB 37 0.020 5MJK-A nrPDB 37 0.025 3LXD-A nrPDB 36 0.044 4C3X-A nrPDB 35 0.052 5UTH-A nrPDB 35 0.054 4ZN0-A nrPDB 35 0.069 4Y4N-A nrPDB 35 0.091 5YGQ-A nrPDB 35 0.099 4Y4M-A nrPDB 34 0.12 4JNQ-A nrPDB 34 0.15 3RHA-A nrPDB 34 0.16 5BR7-A nrPDB 33 0.20 4MO2-B nrPDB 33 0.21 5NMX-A nrPDB 33 0.22 2GMH-A nrPDB 33 0.25 5VJ7-A nrPDB 33 0.28 5HCE-A nrPDB 33 0.32 5XHU-A nrPDB 32 0.46 2ZBW-A nrPDB 32 0.52 3F8P-A nrPDB 32 0.60 5U63-A nrPDB 32 0.61 3K30-A nrPDB 32 0.62 5UWY-A nrPDB 32 0.64 3NIX-A nrPDB 32 0.71 1PS9-A nrPDB 32 0.83 6BWT-A nrPDB 32 0.95 4WEQ-A nrPDB 31 1.2 3UKH-A nrPDB 31 1.3 5L3D-A nrPDB 31 1.5 6GAR-A nrPDB 31 1.6 3ABT-A nrPDB 30 1.7 5W4C-A nrPDB 30 1.8 6GAS-A nrPDB 30 2.3 1I8T-A nrPDB 30 2.4 1F6M-A nrPDB 30 2.7 3COX-A nrPDB 30 3.1 3UP5-A nrPDB 30 3.2 4Z2R-A nrPDB 30 3.6 1NAA-A nrPDB 29 3.7 1XHC-A nrPDB 29 3.7 2VVL-G nrPDB 29 4.1 5USX-A nrPDB 29 4.4 4TXK-A nrPDB 29 5.1 5AYV-A nrPDB 29 5.3 2BRY-A nrPDB 29 5.3 6C6P-A nrPDB 29 5.8 1VL1-A nrPDB 29 6.1 5GVS-A nrPDB 28 7.4 4CBQ-A nrPDB 28 7.7 5H1Y-A nrPDB 28 8.1 5MYJ-BM nrPDB 28 9.3 4YRY-B nrPDB 28 9.9 >5J5Z-A nrPDB Length = 496 Score = 962 bits (2487), Expect = 0.0, Method: Compositional matrix adjust. Identities = 473/474 (99%), Positives = 473/474 (99%) Query: 36 ADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNS 95 ADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNS Sbjct: 23 ADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNS 82 Query: 96 HYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGK 155 HYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGK Sbjct: 83 HYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGK 142 Query: 156 ITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEK 215 ITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEK Sbjct: 143 ITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEK 202 Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN Sbjct: 203 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 262 Query: 276 TKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRG 335 TKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRG Sbjct: 263 TKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRG 322 Query: 336 RIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYT 395 RIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYT Sbjct: 323 RIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYT 382 Query: 396 HPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHI 455 HPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHI Sbjct: 383 HPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHI 442 Query: 456 LGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF 509 LGPGAGEMVNEAALALEYGASCE IARVCHAHPTLSEAFREANLAASFGKSINF Sbjct: 443 LGPGAGEMVNEAALALEYGASCEVIARVCHAHPTLSEAFREANLAASFGKSINF 496 >1V59-A nrPDB Length = 478 Score = 538 bits (1386), Expect = e-153, Method: Compositional matrix adjust. Identities = 272/474 (57%), Positives = 354/474 (74%), Gaps = 11/474 (2%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 102 DV +IG GP GYVAAIKAAQLGF T C+EK LGGTCLNVGCIPSKALLNNSH +H H Sbjct: 7 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMH 66 Query: 103 GKDFASRGIEMS-EVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQ 161 + RGI+++ ++++N+ + K AVK LTGGI LFK+NKV + G G + + Sbjct: 67 -TEAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETK 125 Query: 162 VTATKADG--GT----QVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEK 215 + T DG GT ++D KNI++ATGSEVTPFPGI IDE+ IVSSTGALSLK++P++ Sbjct: 126 IRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKR 185 Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 + +IG G+IG+E+GSV+ RLG+ VT VEF +G +D E++K Q+ L+KQG FKL+ Sbjct: 186 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGA-SMDGEVAKATQKFLKKQGLDFKLS 244 Query: 276 TKVTGATKKSDGKI-DVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPR 334 TKV A + D + ++ +E K E + +VLLV +GRRP+ LG E++G+E+D R Sbjct: 245 TKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKR 304 Query: 335 GRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIY 394 GR+ ++ +F +K P+I +GDV GPMLAHKAE+EGI VE + G H++YN +PSV+Y Sbjct: 305 GRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMY 364 Query: 395 THPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAH 454 +HPEVAWVGK+EEQLKE GI+YK+GKFPFAANSRAKTN DT+G VKIL T+R+LGAH Sbjct: 365 SHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAH 424 Query: 455 ILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSIN 508 I+GP AGEM+ EA LALEYGAS ED+ARVCHAHPTLSEAF+EAN+AA + K+I+ Sbjct: 425 IIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAA-YDKAIH 477 >1DXL-A nrPDB Length = 470 Score = 533 bits (1372), Expect = e-152, Method: Compositional matrix adjust. Identities = 268/467 (57%), Positives = 349/467 (74%), Gaps = 4/467 (0%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 102 DV +IG GPGGYVAAIKAAQLGFKT CIEK LGGTCLNVGCIPSKALL++SH YH A Sbjct: 8 DVVIIGGGPGGYVAAIKAAQLGFKTTCIEKRGALGGTCLNVGCIPSKALLHSSHMYHEAK 67 Query: 103 GKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQV 162 FA+ G+++S V ++L MM QK AV LT GI LFK+NKV +V GYGK +++ Sbjct: 68 -HSFANHGVKVSNVEIDLAAMMGQKDKAVSNLTRGIEGLFKKNKVTYVKGYGKFVSPSEI 126 Query: 163 TATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAG 222 + +G V+ K+I+IATGS+V PG+TIDE IVSSTGAL+L ++P+K+VVIGAG Sbjct: 127 SVDTIEGENTVVKGKHIIIATGSDVKSLPGVTIDEKKIVSSTGALALSEIPKKLVVIGAG 186 Query: 223 VIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGAT 282 IG+E+GSVW R+G++VT VEF + +D EI K FQR L+KQG KFKL TKV G Sbjct: 187 YIGLEMGSVWGRIGSEVTVVEFASEIVPT-MDAEIRKQFQRSLEKQGMKFKLKTKVVGVD 245 Query: 283 KKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTR 342 DG + +++E ++GG+ +I DV+LV GR PFT L L+++G+E D GRI VN R Sbjct: 246 TSGDG-VKLTVEPSAGGEQTIIEADVVLVSAGRTPFTSGLNLDKIGVETDKLGRILVNER 304 Query: 343 FQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWV 402 F T + +YAIGDV+ GPMLAHKAE++G+ CVE +AG H+DY+ VP V+YT+PEVA V Sbjct: 305 FSTNVSGVYAIGDVIPGPMLAHKAEEDGVACVEYLAGKVGHVDYDKVPGVVYTNPEVASV 364 Query: 403 GKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGE 462 GK+EEQ+KE G+EY+VGKFPF ANSRAK + +G+VKI+ +K TD++LG HI+ P AGE Sbjct: 365 GKTEEQVKETGVEYRVGKFPFMANSRAKAIDNAEGLVKIIAEKETDKILGVHIMAPNAGE 424 Query: 463 MVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF 509 +++EAA+AL+Y AS EDIARVCHAHPT+SEA +EA + A++ K I+ Sbjct: 425 LIHEAAIALQYDASSEDIARVCHAHPTMSEAIKEAAM-ATYDKPIHI 470 >3URH-A nrPDB Length = 491 Score = 516 bits (1328), Expect = e-146, Method: Compositional matrix adjust. Identities = 260/472 (55%), Positives = 331/472 (70%), Gaps = 7/472 (1%) Query: 35 YADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNN 94 Y + D+ VIGSGPGGYV AIKAAQLG K +EK T GGTCLNVGCIPSKALL+ Sbjct: 19 YFQSMMAYDLIVIGSGPGGYVCAIKAAQLGMKVAVVEKRSTYGGTCLNVGCIPSKALLHA 78 Query: 95 SHYYHMA-HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGY 153 S +H A HG + G+E++ +LNL KMM K VK+ G++ LFK+NK+ G Sbjct: 79 SEMFHQAQHG--LEALGVEVANPKLNLQKMMAHKDATVKSNVDGVSFLFKKNKIDGFQGT 136 Query: 154 GKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITI--DEDTIVSSTGALSLKK 211 GK+ G+ +V+ T G QV++ KN++IATGS+V PG+ + DE TIVSSTGAL+L+K Sbjct: 137 GKVLGQGKVSVTNEKGEEQVLEAKNVVIATGSDVAGIPGVEVAFDEKTIVSSTGALALEK 196 Query: 212 VPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFK 271 VP M+V+G GVIG+ELGSVW RLGA VT VEFL + G G+D E++K QR+L KQG Sbjct: 197 VPASMIVVGGGVIGLELGSVWARLGAKVTVVEFLDTILG-GMDGEVAKQLQRMLTKQGID 255 Query: 272 FKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIEL 331 FKL KVTGA K DG V+ E GG+A + +V+L+ GR+P T LGL + G+ L Sbjct: 256 FKLGAKVTGAVKSGDGA-KVTFEPVKGGEATTLDAEVVLIATGRKPSTDGLGLAKAGVVL 314 Query: 332 DPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPS 391 D RGR+ ++ FQT I +YAIGDVV GPMLAHKAEDEG+ E +AG A H++Y+ +P Sbjct: 315 DSRGRVEIDRHFQTSIAGVYAIGDVVRGPMLAHKAEDEGVAVAEIIAGQAGHVNYDVIPG 374 Query: 392 VIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVL 451 V+YT PEVA VGK+EE+LK G+ YK+GKFPF AN RA+ TDG VKIL K TDRVL Sbjct: 375 VVYTQPEVASVGKTEEELKAAGVAYKIGKFPFTANGRARAMLQTDGFVKILADKETDRVL 434 Query: 452 GAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASF 503 G HI+G GAGEM++E A+ +E+G S ED+ R CHAHPT+SEA +EA L+ F Sbjct: 435 GGHIIGFGAGEMIHEIAVLMEFGGSSEDLGRTCHAHPTMSEAVKEAALSTFF 486 >2QAE-A nrPDB Length = 468 Score = 468 bits (1204), Expect = e-132, Method: Compositional matrix adjust. Identities = 245/458 (53%), Positives = 316/458 (68%), Gaps = 10/458 (2%) Query: 56 AAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSE 115 A+IKAAQLG KT C+EK LGGTCLNVGCIPSKALL+ +H YH AH +FA G+ E Sbjct: 17 ASIKAAQLGMKTACVEKRGALGGTCLNVGCIPSKALLHATHLYHDAHA-NFARYGLMGGE 75 Query: 116 -VRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVI 174 V ++ KM +QK AVK LTGG+ +LFK+NKV + G G + + DG +++ Sbjct: 76 GVTMDSAKMQQQKERAVKGLTGGVEYLFKKNKVTYYKGEGSFETAHSIRVNGLDGKQEML 135 Query: 175 DTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQR 234 +TK +IATGSE T P + DE ++SSTGAL+L +VP+ MVVIG GVIG+ELGSVW R Sbjct: 136 ETKKTIIATGSEPTELPFLPFDEKVVLSSTGALALPRVPKTMVVIGGGVIGLELGSVWAR 195 Query: 235 LGADVTAVEFLGHVGGVGIDMEISKNFQRILQK-QGFKFKLNTKVTGATKKSDGKIDVSI 293 LGA+VT VEF +D +++ L K + KF +TKV G T D VS+ Sbjct: 196 LGAEVTVVEFAPRCAPT-LDEDVTNALVGALAKNEKMKFMTSTKVVGGTNNGD---SVSL 251 Query: 294 EA-ASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYA 352 E GK E +TC+ LLV +GRRPFT LGL+++ + + RG + + F+T IP++YA Sbjct: 252 EVEGKNGKRETVTCEALLVSVGRRPFTGGLGLDKINVAKNERGFVKIGDHFETSIPDVYA 311 Query: 353 IGDVV-AGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKE 411 IGDVV GPMLAHKAEDEG+ C E +AG H++Y +P+VIYT PEVA VGKSE++LK+ Sbjct: 312 IGDVVDKGPMLAHKAEDEGVACAEILAGKPGHVNYGVIPAVIYTMPEVASVGKSEDELKK 371 Query: 412 EGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALAL 471 EG+ YKVGKFPF ANSRAK + DG VK+L K+TDR+LG HI+ AGE++ EA LA+ Sbjct: 372 EGVAYKVGKFPFNANSRAKAVSTEDGFVKVLVDKATDRILGVHIVCTTAGELIGEACLAM 431 Query: 472 EYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF 509 EYGAS ED+ R CHAHPT+SEA +EA +A F K+INF Sbjct: 432 EYGASSEDVGRTCHAHPTMSEALKEACMAL-FAKTINF 468 >5TR3-A nrPDB Length = 481 Score = 448 bits (1153), Expect = e-126, Method: Compositional matrix adjust. Identities = 236/468 (50%), Positives = 314/468 (67%), Gaps = 11/468 (2%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNE------TLGGTCLNVGCIPSKALLNNSH 96 DV VIG+GPGGYVAAIKAAQLG KT CIEK LGGTCLNVGCIPSKALL++S Sbjct: 9 DVVVIGAGPGGYVAAIKAAQLGLKTACIEKYTDAEGKLALGGTCLNVGCIPSKALLDSSW 68 Query: 97 YYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKI 156 Y A + F GI EV++++ M+ +K+ VK LTGG+A LFK N V + G+GK+ Sbjct: 69 KYKEAK-ESFNVHGISTGEVKMDVAAMVGRKAGIVKNLTGGVATLFKANGVTSIQGHGKL 127 Query: 157 TGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKM 216 +V TKADG T+VI+ +N+++A+GS P +D++ IV STGAL + VP+++ Sbjct: 128 LAGKKVEVTKADGTTEVIEAENVILASGSRPIDIPPAPVDQNVIVDSTGALEFQAVPKRL 187 Query: 217 VVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNT 276 VIGAGVIG+ELGSVW RLGA+VT +E L + D +SK Q+ L KQG KL Sbjct: 188 GVIGAGVIGLELGSVWARLGAEVTVLEALDTFL-MAADTAVSKEAQKTLTKQGLDIKLGA 246 Query: 277 KVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGR 336 +VTG +K + +++V+ A G + IT D L+V +GRRP T +L + G+ +D RG Sbjct: 247 RVTG-SKVNGNEVEVTYTNAEG--EQKITFDKLIVAVGRRPVTTDLLASDSGVTIDERGY 303 Query: 337 IPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTH 396 I V+ T +P +YAIGDVV G MLAHKA +EGI+ VE + G ++Y+ +PSVIYTH Sbjct: 304 IFVDDYCATSVPGVYAIGDVVRGMMLAHKASEEGIMVVERIKGHKAQMNYDLIPSVIYTH 363 Query: 397 PEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHIL 456 PE+AWVGK+E+ LK EG+E VG FPFAA+ RA DT G VK++ TDRVLG H++ Sbjct: 364 PEIAWVGKTEQALKAEGVEVNVGTFPFAASGRAMAANDTGGFVKVIADAKTDRVLGVHVI 423 Query: 457 GPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFG 504 GP A E+V + A+A+E+G S ED+ + +HPTLSEA EA LA + G Sbjct: 424 GPSAAELVQQGAIAMEFGTSAEDLGMMVFSHPTLSEALHEAALAVNGG 471 >5U8W-A nrPDB Length = 481 Score = 443 bits (1139), Expect = e-124, Method: Compositional matrix adjust. Identities = 232/464 (50%), Positives = 308/464 (66%), Gaps = 11/464 (2%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEK------NETLGGTCLNVGCIPSKALLNNSH 96 DV VIG+GPGGYVAAI+AAQLG KT CIEK LGGTCLNVGCIPSKALL++S+ Sbjct: 9 DVVVIGAGPGGYVAAIRAAQLGLKTACIEKYIGKEGKVALGGTCLNVGCIPSKALLDSSY 68 Query: 97 YYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKI 156 YH A + F GIE V +++ M+ +K+ VK LTGGIA LFK N V G+GK+ Sbjct: 69 KYHEAK-EAFKVHGIEAKGVTIDVPAMVARKANIVKNLTGGIATLFKANGVTSFEGHGKL 127 Query: 157 TGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKM 216 QV T DG TQV++ +N++IA+GS P + +D IV STGAL + VP+K+ Sbjct: 128 LANKQVEVTGLDGKTQVLEAENVIIASGSRPVEIPPAPLTDDIIVDSTGALEFQAVPKKL 187 Query: 217 VVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNT 276 VIGAGVIG+ELGSVW RLGA+VT +E L D +I+K ++L KQG +L Sbjct: 188 GVIGAGVIGLELGSVWARLGAEVTVLEALDKFLPAA-DEQIAKEALKVLTKQGLNIRLGA 246 Query: 277 KVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGR 336 +VT + K ++ V+ A+G + E T D L+V +GRRP T +L + G+ LD RG Sbjct: 247 RVTASEVKKK-QVTVTFTDANGEQKE--TFDKLIVAVGRRPVTTDLLAADSGVTLDERGF 303 Query: 337 IPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTH 396 I V+ +T +P ++AIGDVV G MLAHKA +EG++ E +AG ++Y+ +PSVIYTH Sbjct: 304 IYVDDHCKTSVPGVFAIGDVVRGAMLAHKASEEGVMVAERIAGHKAQMNYDLIPSVIYTH 363 Query: 397 PEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHIL 456 PE+AWVGK+E+ LK EG+E VG FPFAA+ RA DT G+VK++ TDRVLG H++ Sbjct: 364 PEIAWVGKTEQTLKAEGVEVNVGTFPFAASGRAMAANDTTGLVKVIADAKTDRVLGVHVI 423 Query: 457 GPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLA 500 GP A E+V + A+ +E+G S ED+ + +HPTLSEA EA LA Sbjct: 424 GPSAAELVQQGAIGMEFGTSAEDLGMMVFSHPTLSEALHEAALA 467 >3LAD-A nrPDB Length = 476 Score = 439 bits (1130), Expect = e-123, Method: Compositional matrix adjust. Identities = 232/470 (49%), Positives = 310/470 (65%), Gaps = 19/470 (4%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNE------TLGGTCLNVGCIPSKALLNNSH 96 DV VIG+GPGGYVAAIK+AQLG KT IEK + LGGTCLNVGCIPSKALL++S+ Sbjct: 5 DVIVIGAGPGGYVAAIKSAQLGLKTALIEKYKGKEGKTALGGTCLNVGCIPSKALLDSSY 64 Query: 97 YYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKI 156 +H AH + F GI EV +++ M+ +K V+ LTGG+A L K N V G+GK+ Sbjct: 65 KFHEAH-ESFKLHGISTGEVAIDVPTMIARKDQIVRNLTGGVASLIKANGVTLFEGHGKL 123 Query: 157 TGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKM 216 +V T ADG +QV+DT+N+++A+GS+ P +D+D IV STGAL + VP K+ Sbjct: 124 LAGKKVEVTAADGSSQVLDTENVILASGSKPVEIPPAPVDQDVIVDSTGALDFQNVPGKL 183 Query: 217 VVIGAGVIGVELGSVWQRLGADVTAVE----FLGHVGGVGIDMEISKNFQRILQKQGFKF 272 VIGAGVIG+ELGSVW RLGA+VT +E FL +D +++K Q+IL KQG K Sbjct: 184 GVIGAGVIGLELGSVWARLGAEVTVLEAMDKFLP-----AVDEQVAKEAQKILTKQGLKI 238 Query: 273 KLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELD 332 L +VTG T+ + ++ V A G K++ D L+V +GRRP T +L + G+ LD Sbjct: 239 LLGARVTG-TEVKNKQVTVKFVDAEGEKSQAF--DKLIVAVGRRPVTTDLLAADSGVTLD 295 Query: 333 PRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSV 392 RG I V+ T +P +YAIGDVV G MLAHKA +EG++ E +AG ++Y+ +P+V Sbjct: 296 ERGFIYVDDYCATSVPGVYAIGDVVRGAMLAHKASEEGVVVAERIAGHKAQMNYDLIPAV 355 Query: 393 IYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLG 452 IYTHPE+A VGK+E+ LK EG+ VG FPFAA+ RA DT G VK++ TDRVLG Sbjct: 356 IYTHPEIAGVGKTEQALKAEGVAINVGVFPFAASGRAMAANDTAGFVKVIADAKTDRVLG 415 Query: 453 AHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAAS 502 H++GP A E+V + A+A+E+G S ED+ + AHP LSEA EA LA S Sbjct: 416 VHVIGPSAAELVQQGAIAMEFGTSAEDLGMMVFAHPALSEALHEAALAVS 465 >6AON-A nrPDB Length = 478 Score = 416 bits (1068), Expect = e-116, Method: Compositional matrix adjust. Identities = 222/475 (46%), Positives = 307/475 (64%), Gaps = 13/475 (2%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET------LGGTCLNVGCIPSKALLNNSH 96 DV VIG+GPGGY+AAI+AAQLG CI+ + GGTC NVGCIPSKALL +S Sbjct: 9 DVVVIGAGPGGYIAAIRAAQLGMSVACIDAWQNGQGGPAPGGTCTNVGCIPSKALLQSSE 68 Query: 97 YYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKI 156 +Y A+ FA GIE+ V L LD ++ +K+T VK GI +LFK+NKV + +G G Sbjct: 69 HYEQAN-HHFAEHGIEVKGVSLKLDTLIGRKNTVVKQNNDGILYLFKKNKVTYFHGKGAF 127 Query: 157 TGK-NQVTATKADGGTQV-IDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPE 214 G+ + + K G T + K++++ATGS PG+ DE I+S+ GAL++ VP+ Sbjct: 128 AGQVDGGWSIKVTGTTDADLVAKHVIVATGSSARELPGLPFDEKNILSNDGALNIGAVPK 187 Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL 274 K+ VIGAGVIG+E+GSVW+RLGA+VT +E + D +++K + KQG + Sbjct: 188 KLGVIGAGVIGLEMGSVWRRLGAEVTILEAMPEFLAAA-DQQVAKEALKSFAKQGLDIQT 246 Query: 275 NTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPR 334 K+ G K + I V A G + +++ D L+V IGR P+T L E +G++LD R Sbjct: 247 GVKI-GEIKAAAKSITVPYVDAKGAEQKLV-VDKLIVSIGRVPYTGGLNAEAVGLKLDER 304 Query: 335 GRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIY 394 G + V+ +T +PN++A+GDVV GPMLAHKAE+EG+ E +AG H+++ VP VIY Sbjct: 305 GFVAVDEDCKTNLPNVWAVGDVVRGPMLAHKAEEEGVAVAERIAGQHGHVNFATVPWVIY 364 Query: 395 THPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAH 454 T PE+AWVGK+E+QLK EG EYK G FPF AN RA+ DT G K++ TD VLG H Sbjct: 365 TSPEIAWVGKTEQQLKAEGREYKAGSFPFMANGRARALGDTTGFAKVIADAKTDEVLGVH 424 Query: 455 ILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF 509 I+GP A E+++EA +E+ + EDIAR+CHAHPTLSEA +EA LA +++NF Sbjct: 425 IIGPMASELISEAVTIMEFRGAAEDIARICHAHPTLSEAVKEAALAVD-KRTLNF 478 >2YQU-A nrPDB Length = 455 Score = 412 bits (1060), Expect = e-115, Method: Compositional matrix adjust. Identities = 213/459 (46%), Positives = 300/459 (65%), Gaps = 13/459 (2%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 102 D+ VIG+GPGGYVAAI+AAQLG K +EK + LGGTCL VGCIPSKALL + + A Sbjct: 3 DLLVIGAGPGGYVAAIRAAQLGMKVGVVEKEKALGGTCLRVGCIPSKALLETTERIYEAK 62 Query: 103 GKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQV 162 G ++ V L+L +M K V+A T G+ LFK+N + G + + +V Sbjct: 63 KGLL---GAKVKGVELDLPALMAHKDKVVQANTQGVEFLFKKNGIARHQGTARFLSERKV 119 Query: 163 TATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAG 222 + + ++ + ILIATGS P +D + +V+ST ALS +VP++++V+G G Sbjct: 120 LVEETG---EELEARYILIATGSAPLIPPWAQVDYERVVTSTEALSFPEVPKRLIVVGGG 176 Query: 223 VIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGAT 282 VIG+ELG VW RLGA+V +E++ + +D+E+S+ +R+ +KQG + +VT Sbjct: 177 VIGLELGVVWHRLGAEVIVLEYMDRILPT-MDLEVSRAAERVFKKQGLTIRTGVRVTAVV 235 Query: 283 KKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTR 342 ++ G V +E GG EV+ D +LV +GRRP+T+ L LE G+ D RGRIPV+ Sbjct: 236 PEAKGA-RVELE---GG--EVLEADRVLVAVGRRPYTEGLSLENAGLSTDERGRIPVDEH 289 Query: 343 FQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWV 402 +T++P+IYAIGDVV GPMLAHKA +EGI VE M G H+DY +PSV+YTHPE+A V Sbjct: 290 LRTRVPHIYAIGDVVRGPMLAHKASEEGIAAVEHMVRGFGHVDYQAIPSVVYTHPEIAAV 349 Query: 403 GKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGE 462 G +EE+LK +GI YKVGKFP++A+ RA+ +T+G +K+L TDR+LG H +G G+ Sbjct: 350 GYTEEELKAQGIPYKVGKFPYSASGRARAMGETEGFIKVLAHAKTDRILGVHGIGARVGD 409 Query: 463 MVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAA 501 ++ EAALAL + AS ED+ R HAHP+LSE +EA LAA Sbjct: 410 VLAEAALALFFKASAEDLGRAPHAHPSLSEILKEAALAA 448 >6BZ0-A nrPDB Length = 480 Score = 395 bits (1016), Expect = e-110, Method: Compositional matrix adjust. Identities = 213/472 (45%), Positives = 301/472 (63%), Gaps = 13/472 (2%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKN-----ETLGGTCLNVGCIPSKALLNNSHY 97 D+ VIG GPGGY AAI+AAQLGFK CIEK +LGGTCLNVGCIPSKALL++SH Sbjct: 9 DLVVIGGGPGGYEAAIRAAQLGFKVACIEKRIHNGKPSLGGTCLNVGCIPSKALLDSSHR 68 Query: 98 YH-MAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKI 156 Y H A GI EV +L K++ +K V LTGGI L K N + + G GK+ Sbjct: 69 YEDTVH--HLADHGITTGEVNFDLAKLLARKDKIVDQLTGGIDQLLKGNGIEWLKGTGKL 126 Query: 157 TGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKM 216 +V +G TQ+++ K +++A+GS P +D+D IV STGAL+ +VP+++ Sbjct: 127 LAGKKVEFVPHEGETQILEPKYVILASGSVPVNIPVAPVDQDIIVDSTGALNFPEVPKRL 186 Query: 217 VVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNT 276 VIGAGVIG+ELGSVW+RLGA+V E + + D +SK +Q+IL KQG ++ Sbjct: 187 GVIGAGVIGLELGSVWRRLGAEVVVFEAMDAFLPMA-DKALSKEYQKILTKQGLDIRIGA 245 Query: 277 KVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGR 336 KV+G + +G+ +V+++ G+ + T D L+VC+GR+ + + L E+ GI+L RG Sbjct: 246 KVSGT--EVNGR-EVTVKYTQAGEDKEQTFDKLIVCVGRKAYAEGLLAEDSGIKLTERGL 302 Query: 337 IPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTH 396 + VN T + +YAIGD+V GPMLAHKA +EG++ VE + G A ++Y+ + S+IYTH Sbjct: 303 VEVNDHCATSVEGVYAIGDLVRGPMLAHKAMEEGVMAVERIHGHAAQVNYDTIISIIYTH 362 Query: 397 PEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHIL 456 PE AWVG +EEQ KE+G E K G+F FA N RA + G VK + TDR+LG H++ Sbjct: 363 PEAAWVGLTEEQAKEKGHEVKTGQFGFAVNGRALAAGEGAGFVKFVADAKTDRLLGMHVI 422 Query: 457 GPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSIN 508 GP A ++V++ +ALE+ +S ED+ + HPT SE EA LA G++I+ Sbjct: 423 GPAASDIVHQGMIALEFVSSVEDLQLMTFGHPTFSEVVHEAALAVD-GRAIH 473 >1EBD-A nrPDB Length = 455 Score = 359 bits (922), Expect = 2e-99, Method: Compositional matrix adjust. Identities = 201/458 (43%), Positives = 278/458 (60%), Gaps = 9/458 (1%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYH 99 I+ + V+G+GPGGYVAAI+AAQLG K +EK LGG CLNVGCIPSKAL++ SH Y Sbjct: 2 IETETLVVGAGPGGYVAAIRAAQLGQKVTIVEKG-NLGGVCLNVGCIPSKALISASHRYE 60 Query: 100 MAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGK 159 A K GI+ V ++ K+ E K++ VK LTGG+ L K NKV V G Sbjct: 61 QA--KHSEEMGIKAENVTIDFAKVQEWKASVVKKLTGGVEGLLKGNKVEIVKGEAYFVDA 118 Query: 160 NQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVI 219 N V D Q KN +IATGS P + I+ STGAL+L +VP+ +VVI Sbjct: 119 NTVRVVNGDS-AQTYTFKNAIIATGSRPIELPNFKFS-NRILDSTGALNLGEVPKSLVVI 176 Query: 220 GAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVT 279 G G IG+ELG+ + G VT +E G + G + +++ ++ L+K+G + N Sbjct: 177 GGGYIGIELGTAYANFGTKVTILEGAGEILS-GFEKQMAAIIKKRLKKKGVEVVTNALAK 235 Query: 280 GATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPV 339 GA ++ DG V++ + G+ + I D +LV +GRRP T LGLE++GI++ RG I V Sbjct: 236 GAEEREDG---VTVTYEANGETKTIDADYVLVTVGRRPNTDELGLEQIGIKMTNRGLIEV 292 Query: 340 NTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEV 399 + + +T +PNI+AIGD+V GP LAHKA EG + E +AG +DY +P+V+++ PE Sbjct: 293 DQQCRTSVPNIFAIGDIVPGPALAHKASYEGKVAAEAIAGHPSAVDYVAIPAVVFSDPEC 352 Query: 400 AWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPG 459 A VG E+Q K+EGI+ KFPFAAN RA DTDG +K++ +K ++GA I+GP Sbjct: 353 ASVGYFEQQAKDEGIDVIAAKFPFAANGRALALNDTDGFLKLVVRKEDGVIIGAQIIGPN 412 Query: 460 AGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREA 497 A +M+ E LA+E G + EDIA HAHPTL E EA Sbjct: 413 ASDMIAELGLAIEAGMTAEDIALTIHAHPTLGEIAMEA 450 >2EQ6-A nrPDB Length = 464 Score = 350 bits (899), Expect = 7e-97, Method: Compositional matrix adjust. Identities = 212/477 (44%), Positives = 299/477 (62%), Gaps = 23/477 (4%) Query: 31 PLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKA 90 P++TY D+ VIG+GPGGY AAI+AAQLG K + +E E +GG CLNVGCIP+KA Sbjct: 3 PMKTY-------DLIVIGTGPGGYHAAIRAAQLGLKVLAVEAGE-VGGVCLNVGCIPTKA 54 Query: 91 LLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHV 150 LL+ + H H K G++ ++ L+L K+ + VK LTGG+ L K N V + Sbjct: 55 LLHAAETLH--HLKVAEGFGLK-AKPELDLKKLGGWRDQVVKKLTGGVGTLLKGNGVELL 111 Query: 151 NGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLK 210 G+ ++ G +V G + K++++ATGSE G ED + ST AL ++ Sbjct: 112 RGFARLVGPKEVEV-----GGERYGAKSLILATGSEPLELKGFPFGED-VWDSTRALKVE 165 Query: 211 K-VPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQG 269 + +P++++VIG G +G+ELG V++RLGA+VT +E++ + G D E + +R L+K+G Sbjct: 166 EGLPKRLLVIGGGAVGLELGQVYRRLGAEVTLIEYMPEILPQG-DPETAALLRRALEKEG 224 Query: 270 FKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGI 329 + + TK G KK DG + V +E A GG+ E + D +LV +GR+P T+ LGLE+ G+ Sbjct: 225 IRVRTKTKAVGYEKKKDG-LHVRLEPAEGGEGEEVVVDKVLVAVGRKPRTEGLGLEKAGV 283 Query: 330 ELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCV 389 ++D RG I VN R +T +P +YAIGD P+LAHKA EG+I E AG DY V Sbjct: 284 KVDERGFIRVNARMETSVPGVYAIGDAARPPLLAHKAMREGLIAAENAAGKDSAFDYQ-V 342 Query: 390 PSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDR 449 PSV+YT PE A VG +EE+ K G + KVGKFP AA+ RA T +GMVK++G + TD Sbjct: 343 PSVVYTSPEWAGVGLTEEEAKRAGYKVKVGKFPLAASGRALTLGGAEGMVKVVGDEETDL 402 Query: 450 VLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKS 506 +LG I+GP AGE++ EAALALE GA+ D+A H HPTLSE+ EA A +F K Sbjct: 403 LLGVFIVGPQAGELIAEAALALEMGATLTDLALTVHPHPTLSESLMEA--AEAFHKQ 457 >4JDR-A nrPDB Length = 474 Score = 345 bits (884), Expect = 3e-95, Method: Compositional matrix adjust. Identities = 198/454 (43%), Positives = 271/454 (59%), Gaps = 7/454 (1%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYH 99 I V V+G+GP GY AA + A LG +TV +E+ TLGG CLNVGCIPSKALL+ + Sbjct: 5 IKTQVVVLGAGPAGYSAAFRCADLGLETVIVERYNTLGGVCLNVGCIPSKALLHVAKVIE 64 Query: 100 MAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGK 159 A K A GI E + ++DK+ K + LTGG+A + K KV VNG GK TG Sbjct: 65 EA--KALAEHGIVFGEPKTDIDKIRTWKEKVINQLTGGLAGMAKGRKVKVVNGLGKFTGA 122 Query: 160 NQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVI 219 N + + + G VI+ N +IA GS P I ++ I ST AL LK+VPE+++V+ Sbjct: 123 NTLE-VEGENGKTVINFDNAIIAAGSRPIQLPFIPHEDPRIWDSTDALELKEVPERLLVM 181 Query: 220 GAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVT 279 G G+IG+E+G+V+ LG+ + VE V D +I K F + + K+ F L TKVT Sbjct: 182 GGGIIGLEMGTVYHALGSQIDVVEMFDQVIPAA-DKDIVKVFTKRISKK-FNLMLETKVT 239 Query: 280 GATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPV 339 K DG I V++E AE D +LV IGR P KNL + G+E+D RG I V Sbjct: 240 AVEAKEDG-IYVTMEGKKA-PAEPQRYDAVLVAIGRVPNGKNLDAGKAGVEVDDRGFIRV 297 Query: 340 NTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEV 399 + + +T +P+I+AIGD+V PMLAHK EG + E +AG + D +PS+ YT PEV Sbjct: 298 DKQLRTNVPHIFAIGDIVGQPMLAHKGVHEGHVAAEVIAGKKHYFDPKVIPSIAYTEPEV 357 Query: 400 AWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPG 459 AWVG +E++ KE+GI Y+ FP+AA+ RA + DGM K++ K + RV+G I+G Sbjct: 358 AWVGLTEKEAKEKGISYETATFPWAASGRAIASDCADGMTKLIFDKESHRVIGGAIVGTN 417 Query: 460 AGEMVNEAALALEYGASCEDIARVCHAHPTLSEA 493 GE++ E LA+E G EDIA HAHPTL E+ Sbjct: 418 GGELLGEIGLAIEMGCDAEDIALTIHAHPTLHES 451 >6CMZ-A nrPDB Length = 466 Score = 271 bits (694), Expect = 3e-73, Method: Compositional matrix adjust. Identities = 174/460 (37%), Positives = 254/460 (55%), Gaps = 13/460 (2%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHG 103 + VIG GPGGYVAAI+A QLG TV +E++ LGGTCLN+GCIPSKAL++ + + A G Sbjct: 11 LLVIGGGPGGYVAAIRAGQLGIPTVLVERDR-LGGTCLNIGCIPSKALIHVADAFEQACG 69 Query: 104 K-DFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQV 162 + GI + +++ K + K V LT G+ L K++ V ++G ++ V Sbjct: 70 HAGEGALGIRVRAPEIDIAKSVAWKDGIVDRLTRGVGALLKKSGVRVLHGEARVIDGKTV 129 Query: 163 TATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAG 222 A G I +++L+ATGSE P + +VSST ALS +P+++VV+GAG Sbjct: 130 EVVSA-GHAVRIGCEHLLLATGSEPVELPSMPFG-GHVVSSTDALSPATLPKRLVVVGAG 187 Query: 223 VIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGAT 282 IG+ELG V+++LG DV+ VE V D E+ + L + G + L KV G Sbjct: 188 YIGLELGIVYRKLGVDVSVVEAAERVL-PAYDAELVRPVADSLARLGVRLWLGHKVLGLD 246 Query: 283 KKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGR-IPVNT 341 K V ++AA G + + + D +LV +GRRP GLE L LD GR + ++ Sbjct: 247 KHGA----VRVQAADGAE-QTLPADRVLVAVGRRPRVDGFGLETL--MLDRNGRALRIDD 299 Query: 342 RFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAW 401 +T + N++AIGDV PMLAH+A +G + E +AG +P+V +T PE+ Sbjct: 300 TCRTSMRNVWAIGDVAGEPMLAHRAMAQGEMVAELIAGRRRQFMPAAIPAVCFTDPEIVT 359 Query: 402 VGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAG 461 G S + G++ FPFAAN RA T TDG V+++ ++ ++G +G G Sbjct: 360 AGWSPDDAHAAGVDCLSASFPFAANGRAMTLQATDGFVRVVARRDNHLIVGWQAVGRGVS 419 Query: 462 EMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAA 501 E+ + +LE GA EDI HAHPTL EA +EA L A Sbjct: 420 ELAAAFSQSLEMGARLEDIGGTIHAHPTLGEALQEAALRA 459 >1LVL-A nrPDB Length = 458 Score = 270 bits (690), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 179/470 (38%), Positives = 266/470 (56%), Gaps = 24/470 (5%) Query: 37 DQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSH 96 Q I + +IG GPGGYVAAI+A QLG TV +E + LGGTCLN+GCIPSKAL++ + Sbjct: 1 QQTIQTTLLIIGGGPGGYVAAIRAGQLGIPTVLVE-GQALGGTCLNIGCIPSKALIHVAE 59 Query: 97 YYHMA-HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGK 155 +H A + + GI ++ RL++ + + K V LT G+A L K++ V V+G+ K Sbjct: 60 QFHQASRFTEPSPLGISVASPRLDIGQSVAWKDGIVDRLTTGVAALLKKHGVKVVHGWAK 119 Query: 156 ITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEK 215 + QV + DG Q I +++L+ATGS P + + ++SST AL+ K +P+ Sbjct: 120 VLDGKQV---EVDG--QRIQCEHLLLATGSSSVELPMLPLG-GPVISSTEALAPKALPQH 173 Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 +VV+G G IG+ELG +++LGA V+ VE + D E++ L+K G L Sbjct: 174 LVVVGGGYIGLELGIAYRKLGAQVSVVEARERILPT-YDSELTAPVAESLKKLGIALHLG 232 Query: 276 TKV----TGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIEL 331 V G +DGK GG+ + D +LV +GRRP TK LE L +++ Sbjct: 233 HSVEGYENGCLLANDGK---------GGQLR-LEADRVLVAVGRRPRTKGFNLECLDLKM 282 Query: 332 DPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPS 391 + I ++ R QT + N++AIGDV PMLAH+A +G + E +AG A + + + Sbjct: 283 N-GAAIAIDERCQTSMHNVWAIGDVAGEPMLAHRAMAQGEMVAEIIAGKARRFEPAAIAA 341 Query: 392 VIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVL 451 V +T PEV VGK+ EQ ++G++ V +FPFAAN RA + G V+++ ++ +L Sbjct: 342 VCFTDPEVVVVGKTPEQASQQGLDCIVAQFPFAANGRAMSLESKSGFVRVVARRDNHLIL 401 Query: 452 GAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAA 501 G +G E+ A +LE GA ED+A HAHPTL EA +EA L A Sbjct: 402 GWQAVGVAVSELSTAFAQSLEMGACLEDVAGTIHAHPTLGEAVQEAALRA 451 >3II4-A nrPDB Length = 466 Score = 261 bits (667), Expect = 5e-70, Method: Compositional matrix adjust. Identities = 168/469 (35%), Positives = 248/469 (52%), Gaps = 11/469 (2%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 102 DV V+G+GPGGYVAAI+AAQLG T +E + GG CLNVGCIPSKALL N+ H+ Sbjct: 7 DVVVLGAGPGGYVAAIRAAQLGLSTAIVEP-KYWGGVCLNVGCIPSKALLRNAELVHI-F 64 Query: 103 GKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQV 162 KD + GI EV + ++ + G+ L K+NK+ ++GYG N + Sbjct: 65 TKDAKAFGIS-GEVTFDYGIAYDRSRKVAEGRVAGVHFLMKKNKITEIHGYGTFADANTL 123 Query: 163 TATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAG 222 DGGT+ + N +IATGS PG ++ + + LS +++P+ +++ GAG Sbjct: 124 LVDLNDGGTESVTFDNAIIATGSSTRLVPGTSLSANVVTYEEQILS-RELPKSIIIAGAG 182 Query: 223 VIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGAT 282 IG+E G V + G DVT VEFL D ++SK ++ +K G TKV Sbjct: 183 AIGMEFGYVLKNYGVDVTIVEFLPR-ALPNEDADVSKEIEKQFKKLGVTILTATKVESI- 240 Query: 283 KKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTR 342 +DG V++ G A+ + + +L IG P + GL++ G+ L R I V+ Sbjct: 241 --ADGGSQVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDRKAIGVDDY 298 Query: 343 FQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHI--DYNCVPSVIYTHPEVA 400 +T + +IYAIGDV LAH AE +G++ E +AG D+ +P + P VA Sbjct: 299 MRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTLGDHRMLPRATFCQPNVA 358 Query: 401 WVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGA 460 G +E+Q + EG + V KFPF AN++A D G VK++ +LG H++G Sbjct: 359 SFGLTEQQARNEGYDVVVAKFPFTANAKAHGVGDPSGFVKLVADAKHGELLGGHLVGHDV 418 Query: 461 GEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF 509 E++ E LA + + ++AR H HPT+SEA +E G INF Sbjct: 419 AELLPELTLAQRWDLTASELARNVHTHPTMSEALQEC-FHGLVGHMINF 466 >5U25-A nrPDB Length = 602 Score = 255 bits (652), Expect = 3e-68, Method: Compositional matrix adjust. Identities = 176/455 (38%), Positives = 255/455 (56%), Gaps = 24/455 (5%) Query: 54 YVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEM 113 Y AA AA G K +E+ +TLGG CLNVGCIPSKALL+N+ + + A+ GI+ Sbjct: 138 YSAAFAAADEGLKVAIVERYKTLGGVCLNVGCIPSKALLHNAAV--IDEVRHLAANGIKY 195 Query: 114 SEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKN--QVTATKAD--- 168 E L++D + K V LTGG+A + K KV + G G+ + +V+ T D Sbjct: 196 PEPELDIDMLRAYKDGVVSRLTGGLAGMAKSRKVDVIQGDGQFLDPHHLEVSLTAGDAYE 255 Query: 169 -----GGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGV 223 G +++ KN +IA GS VT P I D I+ S+GAL+LK+VP K+++IG G+ Sbjct: 256 QAAPTGEKKIVAFKNCIIAAGSRVTKLPFIPEDP-RIIDSSGALALKEVPGKLLIIGGGI 314 Query: 224 IGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQG-FKFK---LNTKVT 279 IG+E+G+V+ LG+ + VE + G+ ++ ++ QKQ ++F +NTK Sbjct: 315 IGLEMGTVYSTLGSRLDVVEMMD-----GLMQGADRDLVKVWQKQNEYRFDNIMVNTKTV 369 Query: 280 GATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPV 339 K DG + V+ E A+ K E D +LV GR P K + E+ G+ + RG I V Sbjct: 370 AVEPKEDG-VYVTFEGANAPK-EPQRYDAVLVAAGRAPNGKLISAEKAGVAVTDRGFIEV 427 Query: 340 NTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEV 399 + + +T +P+IYAIGD+V PMLAHKA EG + E AG + D +P V YT PEV Sbjct: 428 DKQMRTNVPHIYAIGDIVGQPMLAHKAVHEGHVAAENCAGHKAYFDARVIPGVAYTSPEV 487 Query: 400 AWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPG 459 AWVG++E K G + FP+AA+ RA N +G K++ T R++G I+GP Sbjct: 488 AWVGETELSAKASGRKITKANFPWAASGRAIANGCDNGFTKLIFDAETGRIIGGGIVGPN 547 Query: 460 AGEMVNEAALALEYGASCEDIARVCHAHPTLSEAF 494 G+M+ E LA+E G DI + H HPTL E+ Sbjct: 548 GGDMIGEVCLAIEMGCDAADIGKTIHPHPTLGESI 582 >1OJT-A nrPDB Length = 482 Score = 250 bits (639), Expect = 8e-67, Method: Compositional matrix adjust. Identities = 174/455 (38%), Positives = 252/455 (55%), Gaps = 24/455 (5%) Query: 54 YVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEM 113 Y AA AA G K +E+ +TLGG CLNVGCIPSKALL+N+ + + A+ GI+ Sbjct: 19 YSAAFAAADEGLKVAIVERYKTLGGVCLNVGCIPSKALLHNAAV--IDEVRHLAANGIKY 76 Query: 114 SEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKN--QVTATKAD--- 168 E L++D + K V LTGG+A + K KV + G G+ + +V+ T D Sbjct: 77 PEPELDIDMLRAYKDGVVSRLTGGLAGMAKSRKVDVIQGDGQFLDPHHLEVSLTAGDAYE 136 Query: 169 -----GGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGV 223 G +++ KN +IA GS VT P I D I+ S+GAL+LK+VP K+++IG G+ Sbjct: 137 QAAPTGEKKIVAFKNCIIAAGSRVTKLPFIPEDP-RIIDSSGALALKEVPGKLLIIGGGI 195 Query: 224 IGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQG-FKFK---LNTKVT 279 IG+E+G+V+ LG+ + VE + G+ ++ ++ QKQ ++F +NTK Sbjct: 196 IGLEMGTVYSTLGSRLDVVEMMD-----GLMQGADRDLVKVWQKQNEYRFDNIMVNTKTV 250 Query: 280 GATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPV 339 K DG + V+ E A+ K E D +LV GR P K + E+ G+ + RG I V Sbjct: 251 AVEPKEDG-VYVTFEGANAPK-EPQRYDAVLVAAGRAPNGKLISAEKAGVAVTDRGFIEV 308 Query: 340 NTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEV 399 + + +T +P+IYAIGD+V PMLAHKA EG + E AG + D +P V YT PEV Sbjct: 309 DKQMRTNVPHIYAIGDIVGQPMLAHKAVHEGHVAAENCAGHKAYFDARVIPGVAYTSPEV 368 Query: 400 AWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPG 459 AWVG++E K + FP+AA+ RA N K++ T R++G I+GP Sbjct: 369 AWVGETELSAKASARKITKANFPWAASGRAIANGCDKPFTKLIFDAETGRIIGGGIVGPN 428 Query: 460 AGEMVNEAALALEYGASCEDIARVCHAHPTLSEAF 494 G+M+ E LA+E G DI + H HPTL E+ Sbjct: 429 GGDMIGEVCLAIEMGCDAADIGKTIHPHPTLGESI 463 >5X1Y-B nrPDB Length = 554 Score = 230 bits (586), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 161/471 (34%), Positives = 250/471 (53%), Gaps = 24/471 (5%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 102 D+ +IGSG + +AIKA + G K IE+ T+GGTC+N+GC+PSK LL H++ Sbjct: 86 DLLIIGSGAAAFSSAIKAIEYGAKVGMIERG-TVGGTCVNIGCVPSKTLLRAGEIIHLSK 144 Query: 103 GKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQ- 161 F G++ S ++L ++ QK V L K ++ + I G+ + Sbjct: 145 DNPFI--GLQTSAGEVDLASLITQKDKLVSELRNQ-----KYMDLIDEYNFDLIKGEAKF 197 Query: 162 VTATKADGGTQVIDTKNILIATGSEVTPFPGIT-IDEDTIVSSTGALSLKKVPEKMVVIG 220 V A+ + + K LIATG+ + P I+ +++ ++ST L LKK+P+++ VIG Sbjct: 198 VDASTVEVNGAKLSAKRFLIATGASPS-LPQISGLEKMDYLTSTTLLELKKIPKRLTVIG 256 Query: 221 AGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTG 280 +G IG+ELG ++ LG+++T ++ + D EIS++ ++ L +QG V G Sbjct: 257 SGYIGMELGQLFHHLGSEITLMQRSERLLK-EYDPEISESVEKALIEQGINL-----VKG 310 Query: 281 AT---KKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRI 337 AT + G+I + G EVI D LLV GR+P T +L L G+E I Sbjct: 311 ATFERVEQSGEIK-RVYVTVNGSREVIESDQLLVATGRKPNTDSLNLSAAGVETGKNNEI 369 Query: 338 PVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGA-VHIDYNCVPSVIYTH 396 +N QT IYA GDV GP + A EG I + GG ID + VP+V +T+ Sbjct: 370 LINDFGQTSNEKIYAAGDVTLGPQFVYVAAYEGGIITDNAIGGLNKKIDLSVVPAVTFTN 429 Query: 397 PEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHIL 456 P VA VG +EEQ KE+G + K P A RA N +T G+ K++ T +VLG HI+ Sbjct: 430 PTVATVGLTEEQAKEKGYDVKTSVLPLDAVPRAIVNRETTGVFKLVADAETLKVLGVHIV 489 Query: 457 GPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSI 507 AG+++ A+LA+++G + ED+ + T++E + A A +F K I Sbjct: 490 SENAGDVIYAASLAVKFGLTVEDLTETLAPYLTMAEGLKLA--ALTFDKDI 538 >4YWO-A nrPDB Length = 462 Score = 184 bits (468), Expect = 6e-47, Method: Compositional matrix adjust. Identities = 144/460 (31%), Positives = 224/460 (48%), Gaps = 30/460 (6%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHG 103 + +IG G G+ A IKA +LG K V I K E +GGTC+NVGC+PSK +L + Y A Sbjct: 18 LAIIGYGAAGFAAMIKANELGVKPVLIGKGE-IGGTCVNVGCVPSKRMLYIAEIYKKA-- 74 Query: 104 KDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVT 163 R + SEV E+ + L V + G + + Sbjct: 75 -----REVTGSEVYPPFSSFQEKDGLVQEMRKTKYEDLLSYYDVELIQGEARFISPH--- 126 Query: 164 ATKADGGTQVIDTKNILIATGSE--VTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGA 221 A K +G QVI+ + +IATGS + PG+ D+ ++ ALS + + + VIG Sbjct: 127 AVKVNG--QVIEAEKFVIATGSSPLIPRIPGL--DKVGFWTNREALSPDRRIDSLAVIGG 182 Query: 222 GVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGA 281 + +E ++ R+ +V ++ V + E S +RI++ G V Sbjct: 183 RALALEFAQMYSRMKVEVAILQ-RSPVLIPDWEPEASVEARRIMENDGVAVVTGVNVK-E 240 Query: 282 TKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNT 341 +K GKI ++ K EV D +L+ GR+P +LGLE G+ L+ RG I V+ Sbjct: 241 VRKGAGKIVIT------DKGEV-EADEILLATGRKP-NVDLGLENAGVRLNERGGIKVDD 292 Query: 342 RFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVE-GMAGGAVHIDYNCVPSVIYTHPEVA 400 +T P+IYA GDV+ G ML A +G I E + G +D N VP VI+T P +A Sbjct: 293 ELRTDNPHIYAAGDVLGGKMLEALAGRQGSIATENALTGSHKRVDENAVPQVIFTQPNLA 352 Query: 401 WVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGA 460 VG +E + + + E + P ++ ++A+ G VK++ R++G H +G Sbjct: 353 RVGLTEAEARAKEGEVEARVLPMSSVAKAEIINSRLGFVKMVTMNG--RIVGVHAVGENV 410 Query: 461 GEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLA 500 EM+ EAALA+ +GA+ D+ H PT++E+ R LA Sbjct: 411 AEMIGEAALAIRFGATVHDLIDTVHMFPTIAESLRLVALA 450 >1ZK7-A nrPDB Length = 467 Score = 184 bits (467), Expect = 8e-47, Method: Compositional matrix adjust. Identities = 140/472 (29%), Positives = 230/472 (48%), Gaps = 27/472 (5%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHG 103 V VIGSG AA+KA + G + IE+ T+GGTC+NVGC+PSK ++ +H H+ Sbjct: 7 VAVIGSGGAAMAAALKAVEQGAQVTLIERG-TIGGTCVNVGCVPSKIMIRAAHIAHLRRE 65 Query: 104 KDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAH--LFKQNKVVHVNGYGKITGKNQ 161 F GI + ++ K++ Q+ V L L + V+G + Sbjct: 66 SPFDG-GIAATVPTIDRSKLLAQQQARVDELRHAKYEGILGGNPAITVVHGEARFKDDQS 124 Query: 162 VTATKADGGTQVIDTKNILIATGSE--VTPFPGITIDEDTIVSSTGALSLKKVPEKMVVI 219 +T +GG +V+ L+ATG+ V P PG+ E +ST AL+ +PE++ VI Sbjct: 125 LTVRLNEGGERVVMFDRCLVATGASPAVPPIPGL--KESPYWTSTEALASDTIPERLAVI 182 Query: 220 GAGVIGVELGSVWQRLGADVTAVE----FLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 G+ V+ +EL + RLG+ VT + F D I + + +G + + Sbjct: 183 GSSVVALELAQAFARLGSKVTVLARNTLFFRE------DPAIGEAVTAAFRAEGIEVLEH 236 Query: 276 TKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRG 335 T+ + DG+ + + G+ + D LLV GR P T++L L+ G+ ++ +G Sbjct: 237 TQAS-QVAHMDGEF---VLTTTHGE---LRADKLLVATGRTPNTRSLALDAAGVTVNAQG 289 Query: 336 RIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYT 395 I ++ +T PNIYA GD P + A G M GG +D +P+V++T Sbjct: 290 AIVIDQGMRTSNPNIYAAGDCTDQPQFVYVAAAAGTRAAINMTGGDAALDLTAMPAVVFT 349 Query: 396 HPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHI 455 P+VA VG SE + +GIE RA N DT G +K++ ++ + R++G Sbjct: 350 DPQVATVGYSEAEAHHDGIETDSRTLTLDNVPRALANFDTRGFIKLVIEEGSHRLIGVQA 409 Query: 456 LGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSI 507 + P AGE++ AALA+ + +++A + T+ E + A A +F K + Sbjct: 410 VAPEAGELIQTAALAIRNRMTVQELADQLFPYLTMVEGLKLA--AQTFNKDV 459 >4KPR-E nrPDB Length = 499 Score = 181 bits (458), Expect = 8e-46, Method: Compositional matrix adjust. Identities = 135/444 (30%), Positives = 224/444 (50%), Gaps = 18/444 (4%) Query: 76 LGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSE-VRLNLDKMMEQKSTAVKAL 134 LGGTC+NVGCIP K L++ + A KD + G ++ + V+ + +KM E + +L Sbjct: 55 LGGTCVNVGCIPKK-LMHQAALLGQAL-KDSRNYGWKLEDTVKHDWEKMTESVQNHIGSL 112 Query: 135 TGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGIT 194 G ++ KVV+ N YGK G +++ AT G +V + LIATG E + GI Sbjct: 113 NWGYRVALREKKVVYENAYGKFIGPHKIMATNNKGKEKVYSAERFLIATG-ERPRYLGIP 171 Query: 195 IDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGID 254 D++ +SS SL P K +V+GA + +E +G DVT + + + G D Sbjct: 172 GDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVM--VRSILLRGFD 229 Query: 255 MEISKNFQRILQKQGFKF---KLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLV 311 +++ +++ G KF + TK+ + G++ V+ ++ + + + +L+ Sbjct: 230 QDMANKIGEHMEEHGIKFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIEDEFNTVLL 289 Query: 312 CIGRRPFTKNLGLEELGIELDPR-GRIPVNTRFQTKIPNIYAIGDVVAGPM-LAHKAEDE 369 +GR T+ +GLE +G++++ + G+IPV QT +P IYAIGD++ G + L A Sbjct: 290 AVGRDSCTRTIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQA 349 Query: 370 GIICVEGMAGGA-VHIDYNCVPSVIYTHPEVAWVGKSE----EQLKEEGIE-YKVGKFPF 423 G + + + GG+ V DY+ VP+ ++T E G SE E+ EE IE Y +P Sbjct: 350 GRLLAQRLYGGSTVKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPL 409 Query: 424 AANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARV 483 ++ N V I K +RV+G H+LGP AGE+ A AL+ G + + + Sbjct: 410 EWTVPSRDNNKCYAKV-ICNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDST 468 Query: 484 CHAHPTLSEAFREANLAASFGKSI 507 HP +E F ++ G I Sbjct: 469 IGIHPVCAEIFTTLSVTKRSGGDI 492 >1GEU-A nrPDB Length = 450 Score = 174 bits (442), Expect = 6e-44, Method: Compositional matrix adjust. Identities = 130/444 (29%), Positives = 211/444 (47%), Gaps = 27/444 (6%) Query: 59 KAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH--GKDFASRGIEMSEV 116 +AA G K IE E LGGTC+NVGC+P K + + + H G D+ G + + Sbjct: 22 RAAMYGQKCALIEAKE-LGGTCVNVGCVPKKVMWHAAQIREAIHMYGPDY---GFDTTIN 77 Query: 117 RLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDT 176 + N + ++ ++ + + ++ +N V + G+ + V A + + I Sbjct: 78 KFNWETLIASRTAYIDRIHTSYENVLGKNNVDVIKGFARF-----VDAKTLEVNGETITA 132 Query: 177 KNILIATGSEVT--PFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQR 234 +ILIATG + PG+ + S G +L +PE++ V+GAG IGVELG V Sbjct: 133 DHILIATGGRPSHPDIPGVEYG----IDSDGFFALPALPERVAVVGAGYIGVELGGVING 188 Query: 235 LGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIE 294 LGA E D IS+ ++ +G + N K +DG + + +E Sbjct: 189 LGAKTHLFEMF-DAPLPSFDPMISETLVEVMNAEGPQLHTNAIPKAVVKNTDGSLTLELE 247 Query: 295 AASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIG 354 G++E + C L+ IGR P N+ LE G++ + +G I V+ T I IYA+G Sbjct: 248 ---DGRSETVDC--LIWAIGREPANDNINLEAAGVKTNEKGYIVVDKYQNTNIEGIYAVG 302 Query: 355 DVVAGPMLAHKAEDEGIICVEGMAGGAV--HIDYNCVPSVIYTHPEVAWVGKSEEQLKEE 412 D L A G E + H+DY+ +P+V+++HP + VG +E Q +E+ Sbjct: 303 DNTGAVELTPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIGTVGLTEPQAREQ 362 Query: 413 --GIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALA 470 + KV K F A A T +K++ S ++++G H +G G EM+ A+A Sbjct: 363 YGDDQVKVYKSSFTAMYTAVTTHRQPCRMKLVCVGSEEKIVGIHGIGFGMDEMLQGFAVA 422 Query: 471 LEYGASCEDIARVCHAHPTLSEAF 494 L+ GA+ +D HPT +E F Sbjct: 423 LKMGATKKDFDNTVAIHPTAAEEF 446 >2CFY-A nrPDB Length = 521 Score = 174 bits (440), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 136/446 (30%), Positives = 222/446 (49%), Gaps = 22/446 (4%) Query: 76 LGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSE-VRLNLDKMMEQKSTAVKAL 134 LGGTC+NVGCIP K L++ + A +D + G ++ E V+ + D+M+E + +L Sbjct: 77 LGGTCVNVGCIPKK-LMHQAALLGQAL-QDSRNYGWKVEETVKHDWDRMIEAVQNHIGSL 134 Query: 135 TGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGIT 194 G ++ KVV+ N YG+ G +++ AT G ++ + LIATG E + GI Sbjct: 135 NWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATG-ERPRYLGIP 193 Query: 195 IDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGID 254 D++ +SS SL P K +V+GA + +E +G DVT + + + G D Sbjct: 194 GDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVM--VRSILLRGFD 251 Query: 255 MEISKNFQRILQKQGFKF---KLNTKVTGATKKSDGKIDVSIEAASGGKAEVIT--CDVL 309 +++ +++ G KF + KV + G++ V A S E+I + + Sbjct: 252 QDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV--AQSTNSEEIIEGEYNTV 309 Query: 310 LVCIGRRPFTKNLGLEELGIELDPR-GRIPVNTRFQTKIPNIYAIGDVVAGPM-LAHKAE 367 ++ IGR T+ +GLE +G++++ + G+IPV QT +P IYAIGD++ + L A Sbjct: 310 MLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAI 369 Query: 368 DEGIICVEGM-AGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQ----LKEEGIE-YKVGKF 421 G + + + AG V DY VP+ ++T E G SEE+ EE IE Y + Sbjct: 370 QAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFW 429 Query: 422 PFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIA 481 P ++ N + I K +RV+G H+LGP AGE+ A AL+ G + + + Sbjct: 430 PLEWTIPSRDNNKCYAKI-ICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLD 488 Query: 482 RVCHAHPTLSEAFREANLAASFGKSI 507 HP +E F ++ G SI Sbjct: 489 STIGIHPVCAEVFTTLSVTKRSGASI 514 >2R9Z-A nrPDB Length = 463 Score = 171 bits (434), Expect = 6e-43, Method: Compositional matrix adjust. Identities = 127/455 (27%), Positives = 217/455 (47%), Gaps = 23/455 (5%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 102 D+ IG G GG A KAA G + IE ++ LGGTC+NVGC+P K + SH Sbjct: 6 DLIAIGGGSGGLAVAEKAAAFGKRVALIE-SKALGGTCVNVGCVPKKVMWYASHLAEAV- 63 Query: 103 GKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQV 162 +D G++ S L+ +++ + + A+ ++ + V+G+ + + + Sbjct: 64 -RDAPGFGVQASGGTLDWPRLVAGRDRYIGAINSFWDGYVERLGITRVDGHARFVDAHTI 122 Query: 163 TATKADGGTQVIDTKNILIATGSE--VTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIG 220 + +G Q + +I+IATG V PG + ++S G +L++ P+++ +IG Sbjct: 123 ---EVEG--QRLSADHIVIATGGRPIVPRLPGAELG----ITSDGFFALQQQPKRVAIIG 173 Query: 221 AGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTG 280 AG IG+EL + + G++VT V + D +S + QG + L V Sbjct: 174 AGYIGIELAGLLRSFGSEVTVVALEDRLL-FQFDPLLSATLAENMHAQGIETHLEFAVAA 232 Query: 281 ATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVN 340 + + G ++ A G + E D ++ +GR P T++LGLE GIE+ G +P + Sbjct: 233 LERDAQG---TTLVAQDGTRLE--GFDSVIWAVGRAPNTRDLGLEAAGIEVQSNGMVPTD 287 Query: 341 TRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVH--IDYNCVPSVIYTHPE 398 T +P +YA+GD+ L A G E + G +DY+ +P+V++ HP Sbjct: 288 AYQNTNVPGVYALGDITGRDQLTPVAIAAGRRLAERLFDGQSERKLDYDNIPTVVFAHPP 347 Query: 399 VAWVGKSEEQLKEE-GIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILG 457 ++ VG SE + +E G V + F A +K++ RV+G H++G Sbjct: 348 LSKVGLSEPEARERLGDVLTVYETSFTPMRYALNEHGPKTAMKLVCAGPEQRVVGVHVIG 407 Query: 458 PGAGEMVNEAALALEYGASCEDIARVCHAHPTLSE 492 GA EM+ A+A++ GA+ D HP +E Sbjct: 408 DGADEMLQGFAVAVKMGATKADFDNTVAIHPGSAE 442 >2WOV-A nrPDB Length = 495 Score = 164 bits (414), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 138/473 (29%), Positives = 218/473 (46%), Gaps = 35/473 (7%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET---------LGGTCLNVGCIPSKALLN 93 D+ VIG+G GG A AA L K V + +T LGGTC+NVGC+P K ++ Sbjct: 9 DLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCVPKKLMVT 68 Query: 94 NSHYYHMAHGKDFASRGIEM--SEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNK-VVHV 150 + Y M H ++ A G E S V+ N K++ K+ AV + +F + + Sbjct: 69 GAQY--MDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFNDTEGLDFF 126 Query: 151 NGYGKITGKNQV----TATKADGGTQVIDTKNILIATGS--EVTPFPGITIDEDTIVSST 204 G+G + KN V TA + + +IL+ATGS ++ PGI + +SS Sbjct: 127 LGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGI----EHCISSN 182 Query: 205 GALSLKKVPEKMVVIGAGVIGVELGSV---WQRLGADVTAVEFLGHVGGVGIDMEISKNF 261 A L + P +++ +G G I VE + ++ G VT + ++ G D I + Sbjct: 183 EAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLC-YRNNLILRGFDETIREEV 241 Query: 262 QRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKN 321 + L G + N + +DG V+ E+ + + DV+++ IGR P T + Sbjct: 242 TKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESG-----KTLDVDVVMMAIGRIPRTND 296 Query: 322 LGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGA 381 L L +G++L P+G + V+ +T +PNIYAIGD+ ML A +EG V+ + G Sbjct: 297 LQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALVDTVFGNK 356 Query: 382 VH-IDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMV- 439 D+ V S +++ P + G EE +E + V F + + V Sbjct: 357 PRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGSKYKKFVA 416 Query: 440 KILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSE 492 KI+ S VLG H+LG GA E++ + L A D HPT +E Sbjct: 417 KIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAE 469 >1ZDL-A nrPDB Length = 517 Score = 164 bits (414), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 138/478 (28%), Positives = 221/478 (46%), Gaps = 20/478 (4%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET--------LGGTCLNVGCIPSKALLNN 94 D+ VIG G GG A +AAQLG K + E LGGTC+NVGCIP K + Sbjct: 34 DLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQA 93 Query: 95 SHYYHMAHGKDFASRGIEMSE-VRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGY 153 + M +D G E+++ V+ N M E VK+L G + KV + N Sbjct: 94 ALLGGMI--RDAHHYGWEVAQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIK 151 Query: 154 GKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVP 213 ++ V G ++ ++I+IATG + + ++S LK+ P Sbjct: 152 ASFVDEHTVRGVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIFWLKESP 211 Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFK 273 K +V+GA + +E +G D T + + + G D ++S ++ G +F Sbjct: 212 GKTLVVGASYVALECAGFLTGIGLDTTVM--MRSIPLRGFDQQMSSLVTEHMESHGTQFL 269 Query: 274 LNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDP 333 + K ++ V+ E + GK + T D +L IGR P T+ L LE+ GI +P Sbjct: 270 KGCVPSHIKKLPTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNLEKAGISTNP 329 Query: 334 RG-RIPVNTRFQTKIPNIYAIGDVVAG-PMLAHKAEDEGIICVEGMAG-GAVHIDYNCVP 390 + +I V+ + T +P+IYAIGDV G P L A G + + + G + +DY+ VP Sbjct: 330 KNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMDYSNVP 389 Query: 391 SVIYTHPEVAWVGKSEEQL----KEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKS 446 + ++T E VG SEE+ +E +E + + A +A + + ++ Sbjct: 390 TTVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRDASQCYIKMVCMREP 449 Query: 447 TDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFG 504 VLG H LGP AGE+ AL ++ GAS + + HPT SE + +++ G Sbjct: 450 PQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHPTCSEEVVKLHISKRSG 507 >6B4O-A nrPDB Length = 452 Score = 164 bits (414), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 130/443 (29%), Positives = 206/443 (46%), Gaps = 25/443 (5%) Query: 59 KAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRL 118 +A G + IE NE +GGTC+NVGC+P K + S M +D A G ++ Sbjct: 24 RAGMHGANVLLIEGNE-IGGTCVNVGCVPKKVMWQASSMMEMME-RDTAGYGFDVEIKNF 81 Query: 119 NLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKN 178 + +++E + + L G N + ++GY TG+ + GT+ + Sbjct: 82 SFKQLVENREKYIDFLHGAYNRGLDSNNIERIHGYATFTGEQTIEVN----GTEYT-APH 136 Query: 179 ILIATGSEVTPF--PGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLG 236 ILIATG PG E+ + S G +L+++P+++V +GAG I EL LG Sbjct: 137 ILIATGGRPKKLGIPG----EEYALDSNGFFALEEMPKRVVFVGAGYIAAELAGTLHGLG 192 Query: 237 ADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAA 296 A+ T F D +S+ Q+ G + N K + + ++ E Sbjct: 193 AE-THWAFRHERPLRSFDDMLSEKVVERYQEMGMQIHPNATPAKIEKTAQNEYVITFE-- 249 Query: 297 SGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPN-IYAIGD 355 E IT D ++ GR+P T LGLE + LD +G + V+ +FQ N IYA+GD Sbjct: 250 ---NGESITTDAVIFGTGRQPNTDQLGLENTKVALDEKGYVKVD-KFQNTTQNGIYAVGD 305 Query: 356 VVAGPMLAHKAEDEGIICVEGMAGGA--VHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEG 413 V+ L A G E + G +++DYN VP+V++THP VA +G +E+ EE Sbjct: 306 VIGKIDLTPVAIAAGRRLSERLFNGQTDLYLDYNLVPTVVFTHPPVATIGLTEKAALEEY 365 Query: 414 IE--YKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALAL 471 E K+ + F A +K++ ++++G H +G G EM+ A+A+ Sbjct: 366 GEDQVKIYRSSFTPMYFALGEYRQKCDMKLICVGKEEKIVGLHGIGIGVDEMLQGFAVAI 425 Query: 472 EYGASCEDIARVCHAHPTLSEAF 494 + GA+ D HPT SE F Sbjct: 426 KMGATKADFDNTVAIHPTGSEEF 448 >2AAQ-A nrPDB Length = 479 Score = 163 bits (413), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 145/477 (30%), Positives = 227/477 (47%), Gaps = 53/477 (11%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 102 D VIG G GG +A +AA+LG + +E ++ LGGTC+NVGC+P K + N + + H Sbjct: 23 DYLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTCVNVGCVPKKVMWNTAVHSEFMH 81 Query: 103 GKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQV 162 D A G E + N + E++ V L + ++ + + G+ T + Sbjct: 82 --DHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPKP 139 Query: 163 TATKADGGTQVIDTKNILIATGS-EVTP----FPGITIDEDTIVSSTGALSLKKVPEKMV 217 T + + +ILIATG TP PG ++ ++S G L+++P + V Sbjct: 140 TI---EVSGKKYTAPHILIATGGMPSTPHESQIPGASLG----ITSDGFFQLEELPGRSV 192 Query: 218 VIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGV-GIDMEISKNFQRILQKQGFKFKLNT 276 ++GAG I VE+ + LG+ + + + H + D IS N L+ G + L Sbjct: 193 IVGAGYIAVEMAGILSALGSKTSLM--IRHDKVLRSFDSMISTNCTEELENAGVEV-LKF 249 Query: 277 KVTGATKKSDGKIDVSIEAASGGKAEVIT----CDVLLVCIGRRPFTKNLGLEELGIELD 332 KK+ ++VS+ A G+ V+T D LL IGR P TK+L L +LGI+ D Sbjct: 250 SQVKEVKKTLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD 309 Query: 333 PRGRIPVNTRFQTKIPNIYAIGDV-----------VAGPMLAHK----AEDEGIICVEGM 377 +G I V+ T + IYA+GDV AG LAH+ ED Sbjct: 310 DKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDS-------- 361 Query: 378 AGGAVHIDYNCVPSVIYTHPEVAWVGKSE-EQLKEEGIE-YKVGKFPFAANSRAKTNADT 435 +DYN +P+V+++HP + VG +E E + + GIE K F A T T Sbjct: 362 -----KLDYNNIPTVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKT 416 Query: 436 DGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSE 492 ++K++ ++V+G H+ G G EM+ A+A++ GA+ D HPT SE Sbjct: 417 KCVMKMVCANKEEKVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSE 473 >1FEC-A nrPDB Length = 490 Score = 162 bits (409), Expect = 4e-40, Method: Compositional matrix adjust. Identities = 142/483 (29%), Positives = 224/483 (46%), Gaps = 33/483 (6%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCI---EKNE------TLGGTCLNVGCIPSKALLN 93 D+ VIG+G GG A AA L K V + +K+ LGGTC+NVGC+P K ++ Sbjct: 5 DLVVIGAGSGGLEAGWNAASLHKKRVAVIDLQKHHGPPHYAALGGTCVNVGCVPKKLMVT 64 Query: 94 NSHYYHMAHGKDFASRGIEMSE--VRLNLDKMMEQKSTAVKALTGGIAHLFKQNK-VVHV 150 ++Y M ++ A G E+ VR N ++ K+ AV + +F + + Sbjct: 65 GANY--MDTIRESAGFGWELDRESVRPNWKALIAAKNKAVSGINDSYEGMFADTEGLTFH 122 Query: 151 NGYGKITGKNQVTATK-ADGGTQVI---DTKNILIATGSEVTPFPGITIDEDTIVSSTGA 206 G+G + + V + AD + V+ DT+ IL+ATGS GI D D ++S A Sbjct: 123 QGFGALQDNHTVLVRESADPNSAVLETLDTEYILLATGSWPQHL-GIEGD-DLCITSNEA 180 Query: 207 LSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVE--FLGHVGGVGIDMEISKNFQRI 264 L + P++ + +G G I +E ++ A V+ + G + G D E+ K Sbjct: 181 FYLDEAPKRALCVGGGYISIEFAGIFNAYKARGGQVDLAYRGDMILRGFDSELRKQLTEQ 240 Query: 265 LQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGL 324 L+ G + + TK +DG V E SG +A+ DV+++ IGR P ++ L L Sbjct: 241 LRANGINVRTHENPAKVTKNADGTRHVVFE--SGAEADY---DVVMLAIGRVPRSQTLQL 295 Query: 325 EELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGM-AGGAVH 383 E+ G+E+ G I V+ +T + NIYAIGDV ML A +EG V+ + A Sbjct: 296 EKAGVEVAKNGAIKVDAYSKTNVDNIYAIGDVTDRVMLTPVAINEGAAFVDTVFANKPRA 355 Query: 384 IDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIE---YKVGKFPFAANSRAKTNADTDGMVK 440 D+ V +++ P + G EE ++ + Y+ P N T MV+ Sbjct: 356 TDHTKVACAVFSIPPMGVCGYVEEDAAKKYDQVAVYESSFTPLMHNISGSTYKKF--MVR 413 Query: 441 ILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLA 500 I+ + VLG H+LG + E++ A+ L+ GA D HPT +E Sbjct: 414 IVTNHADGEVLGVHMLGDSSPEIIQSVAICLKMGAKISDFYNTIGVHPTSAEELCSMRTP 473 Query: 501 ASF 503 A F Sbjct: 474 AYF 476 >2X8H-A nrPDB Length = 598 Score = 161 bits (408), Expect = 5e-40, Method: Compositional matrix adjust. Identities = 145/489 (29%), Positives = 222/489 (45%), Gaps = 28/489 (5%) Query: 41 DADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET--------LGGTCLNVGCIPSKALL 92 D D+ VIG G GG A +AA+ G KT ++ E LGGTC+NVGCIP K + Sbjct: 107 DYDLIVIGGGSGGLAAGKEAAKYGAKTAVLDYVEPTPIGTTWGLGGTCVNVGCIPKKLMH 166 Query: 93 NNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNG 152 H + ++ S++ N M+E + + +L G + N+V ++N Sbjct: 167 QAGLLSHALEDAEHFGWSLDRSKISHNWSTMVEGVQSHIGSLNWGYKVALRDNQVTYLNA 226 Query: 153 YGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKV 212 G++ ++V T + I I++ATG E +P I + ++S SL Sbjct: 227 KGRLISPHEVQITDKNQKVSTITGNKIILATG-ERPKYPEIPGAVEYGITSDDLFSLPYF 285 Query: 213 PEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKF 272 P K +VIGA + +E LG DVT + + + G D ++++ ++ G KF Sbjct: 286 PGKTLVIGASYVALECAGFLASLGGDVTVM--VRSILLRGFDQQMAEKVGDYMENHGVKF 343 Query: 273 -KL-------NTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGL 324 KL KV G + V G K E + ++ +GR P + Sbjct: 344 AKLCVPDEIKQLKVVDTENNKPGLLLVKGHYTDGKKFEE-EFETVIFAVGREPQLSKVLC 402 Query: 325 EELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAG-PMLAHKAEDEGIICVEGMAGGAVH 383 E +G++LD GR+ QT + N+YAIGD+ AG P L A G + GA Sbjct: 403 ETVGVKLDKNGRVVCTDDEQTTVSNVYAIGDINAGKPQLTPVAIQAGRYLARRLFAGATE 462 Query: 384 I-DYNCVPSVIYTHPEVAWVGKSEEQLKE----EGIEYKVGKFPFAANSRAKTNADTDGM 438 + DY+ V + ++T E G SEE E + IE F + A D Sbjct: 463 LTDYSNVATTVFTPLEYGACGLSEEDAIEKYGDKDIEVYHSNFKPLEWTVAH-REDNVCY 521 Query: 439 VKILGQKSTD-RVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREA 497 +K++ +KS + RVLG H+LGP AGE+ A+A++ GA+ D R HPT SE F Sbjct: 522 MKLVCRKSDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKADFDRTIGIHPTCSETFTTL 581 Query: 498 NLAASFGKS 506 ++ G S Sbjct: 582 HVTKKSGVS 590 >2YAU-A nrPDB Length = 511 Score = 157 bits (396), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 136/487 (27%), Positives = 221/487 (45%), Gaps = 35/487 (7%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET---------LGGTCLNVGCIPSKALLN 93 D+ V+G+G GG A AA K V + + LGGTC+NVGC+P K ++ Sbjct: 26 DLVVLGAGSGGLEAGWNAAVTHKKKVAVVDVQATHGPPLFAALGGTCVNVGCVPKKLMVT 85 Query: 94 NSHYYHMAHGKDFASRGIEMSEVRL--NLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVN 151 + Y + ++ G EM L N ++ K+ V ++ +F + + + Sbjct: 86 GAQYMDLI--RESGGFGWEMDRESLCPNWKTLIAAKNKVVNSINESYKSMFADTEGLSFH 143 Query: 152 -GYGKITGKNQVTATKADGG----TQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGA 206 G+G + + V K++ + +DT+ ILIATGS T G+ DE I S+ A Sbjct: 144 MGFGALQDAHTVVVRKSEDPHSDVLETLDTEYILIATGSWPTRL-GVPGDEFCITSNE-A 201 Query: 207 LSLKKVPEKMVVIGAGVIGVELGSV---WQRLGADVTAVEFLGHVGGVGIDMEISKNFQR 263 L+ P++M+ +G G I VE + ++ G V + G + G D E+ K+ + Sbjct: 202 FYLEDAPKRMLCVGGGYIAVEFAGIFNGYKPCGGYVDLC-YRGDLILRGFDTEVRKSLTK 260 Query: 264 ILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLG 323 L G + + N T TK DG V + G E D +++ IGR P ++ L Sbjct: 261 QLGANGIRVRTNLNPTKITKNEDGSNHVHF---NDGTEE--DYDQVMLAIGRVPRSQALQ 315 Query: 324 LEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVH 383 L++ G+ G + V+ +T + NIYAIGDV ML A +EG VE + GG Sbjct: 316 LDKAGVRTGKNGAVQVDAYSKTSVDNIYAIGDVTNRVMLTPVAINEGAAFVETVFGGKPR 375 Query: 384 -IDYNCVPSVIYTHPEVAWVGKSEEQLKE--EGIEYKVGKF-PFAANSRAKTNADTDGMV 439 D+ V +++ P + G +EE+ + E + F P N + + M+ Sbjct: 376 ATDHTKVACAVFSIPPIGTCGMTEEEAAKNYETVAVYASSFTPLMHNISGSKHKEF--MI 433 Query: 440 KILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANL 499 +I+ +S VLG H+LG A E++ + ++ GA D HPT +E Sbjct: 434 RIITNESNGEVLGVHMLGDSAPEIIQSVGICMKMGAKISDFHSTIGVHPTSAEELCSMRT 493 Query: 500 AASFGKS 506 A F +S Sbjct: 494 PAYFYES 500 >3L8K-A nrPDB Length = 466 Score = 155 bits (391), Expect = 5e-38, Method: Compositional matrix adjust. Identities = 127/466 (27%), Positives = 214/466 (45%), Gaps = 39/466 (8%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 102 DV VIG+G GY A + A+ + + + LGG CL GC+PSK + Sbjct: 6 DVVVIGAGGAGYHGAFRLAKAKYNVLMADPKGELGGNCLYSGCVPSKTVREVIQ------ 59 Query: 103 GKDFASRGIEMSEVRLNLD-KMMEQKSTAVKALTGGIAHLFKQNK--------VVHVNGY 153 A R ++ V++ LD ++ + V+ L FKQ+K + GY Sbjct: 60 ---TAWRLTNIANVKIPLDFSTVQDRKDYVQELR------FKQHKRNMSQYETLTFYKGY 110 Query: 154 GKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPF--PGIT--IDEDTIVSSTGALSL 209 KI V +G +T+ ++IA+G+E PG+ + D I S Sbjct: 111 VKIKDPTHVIVKTDEGKEIEAETRYMIIASGAETAKLRLPGVEYCLTSDDIFGYKT--SF 168 Query: 210 KKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQG 269 +K+P+ MV+IGAG IG+E+ S+++ +G +E L D +I IL+ Sbjct: 169 RKLPQDMVIIGAGYIGLEIASIFRLMGVQTHIIEMLDRALITLEDQDIVNTLLSILK--- 225 Query: 270 FKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGI 329 K N+ VT K D + +V G K + T V+L GRRP G E+G+ Sbjct: 226 LNIKFNSPVTEVKKIKDDEYEVIYSTKDGSKKSIFTNSVVLAA-GRRPVIPE-GAREIGL 283 Query: 330 ELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDY--- 386 + G I V+ +T IPN++A GD H A I + + +DY Sbjct: 284 SISKTG-IVVDETMKTNIPNVFATGDANGLAPYYHAAVRMSIAAANNIMANGMPVDYVDV 342 Query: 387 NCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKS 446 +P IYT P +++VG + ++ GIE ++ + A+ +G++K++ ++ Sbjct: 343 KSIPVTIYTIPSLSYVGILPSKARKMGIEIVEAEYNMEEDVSAQIYGQKEGVLKLIFERG 402 Query: 447 TDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSE 492 + R++GA ++G + ++NE LA+ YG + + +A HP+ +E Sbjct: 403 SMRLIGAWMIGVHSQYLINELGLAVAYGLNAKQLASFAEQHPSTNE 448 >6N7F-A nrPDB Length = 453 Score = 154 bits (388), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 134/462 (29%), Positives = 212/462 (45%), Gaps = 25/462 (5%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYH 99 I D VIG G G +A +AA G K + E E +GGTC+N+GC+P K + + Sbjct: 6 IPYDYIVIGGGSAGIASANRAAMHGAKVLLAEGKE-IGGTCVNLGCVPKKVMWYGAQVAD 64 Query: 100 M--AHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKIT 157 + + KD+ G + E + ++ + + + F+QN V + Y Sbjct: 65 ILGTYAKDY---GFDFKEKAFDFKQLKANRQAYIDRIHASYERGFEQNGVDRIYDYAVFK 121 Query: 158 GKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMV 217 + V Q+ +ILIATG FP I + I SS G +L +VP++ Sbjct: 122 DAHTVEIAG-----QLYTAPHILIATGGHPV-FPDIEGAQYGI-SSDGFFALDEVPKRTA 174 Query: 218 VIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGV-GIDMEISKNFQRILQKQGFKFKLNT 276 V+GAG I VEL V LG+ F+ H + D I + G + + Sbjct: 175 VVGAGYIAVELAGVLHALGSKTDL--FIRHDRPLRSFDKTIVDVLVDEMAVNGPRLHTHA 232 Query: 277 KVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGR 336 +V K +D + + ++ G + EV D L+ IGR+P + L++ G+ L+ +G Sbjct: 233 EVAKVVKNTDESLTLYLK--DGQEVEV---DQLIWAIGRKPNLEGFSLDKTGVTLNDKGY 287 Query: 337 IPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAV--HIDYNCVPSVIY 394 I + T + IYA+GDV L A G E + G +DY V +VI+ Sbjct: 288 IETDAYENTSVKGIYAVGDVNGKLALTPVAVAAGRRLSERLFNGKTDEKLDYQNVATVIF 347 Query: 395 THPEVAWVGKSEEQ-LKEEGIE-YKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLG 452 +HP + VG SEE +K+ G E K + F + A TN ++K++ T++++G Sbjct: 348 SHPVIGSVGLSEEAAVKQYGQEAVKTYQSRFTSMFTAITNHRQPCLMKLVTVGDTEKIVG 407 Query: 453 AHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAF 494 H +G G EM+ A+A++ GA+ D HPT SE F Sbjct: 408 LHGIGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEF 449 >6DU7-A nrPDB Length = 448 Score = 153 bits (386), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 125/445 (28%), Positives = 209/445 (46%), Gaps = 30/445 (6%) Query: 59 KAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH--GKDFASRGIEMSEV 116 +A + G + IE+ + LGGTC+NVGC+P K + + H G+D+ G + +++ Sbjct: 21 RAGEHGAQAAVIEEKK-LGGTCVNVGCVPKKIMWYGAQIAETFHQFGEDY---GFKTTDL 76 Query: 117 RLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDT 176 + + + + + FK+N V + G+ + + V+ ++I Sbjct: 77 NFDFATLRRNRESYIDRARSSYDGSFKRNGVDLIEGHAEFVDSHTVSVNG-----ELIRA 131 Query: 177 KNILIATGSE--VTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQR 234 K+I+IATG+ + PG + SS + +++PE + ++GAG I VEL V Sbjct: 132 KHIVIATGAHPSIPNIPGAELGG----SSDDVFAWEELPESVAILGAGYIAVELAGVLHT 187 Query: 235 LGADVTAVEFLGHVGGV-GIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSI 293 G V F+ + G D I + + +++ + K +DG I + Sbjct: 188 FG--VKTDLFVRRDRPLRGFDSYIVEGLVKEMERTNLPLHTHKVPVKLEKTTDG-ITIHF 244 Query: 294 EAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAI 353 E + T ++ GRRP K L LE+ G+ L+ RG I V+ T + IYA+ Sbjct: 245 EDGTSH-----TASQVIWATGRRPNVKGLQLEKAGVTLNERGFIQVDEYQNTVVEGIYAL 299 Query: 354 GDVVAGPMLAHKAEDEGIICVEGMAGG--AVHIDYNCVPSVIYTHPEVAWVGKSEEQ-LK 410 GDV L A G E + G +DY+ +P+V+++HP + VG +EEQ +K Sbjct: 300 GDVTGEKELTPVAIKAGRTLSERLFNGKTTAKMDYSTIPTVVFSHPAIGTVGLTEEQAIK 359 Query: 411 EEGI-EYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAAL 469 E G + KV K FA+ A T + K++ S ++V+G H +G G EM+ A+ Sbjct: 360 EYGQDQIKVYKSSFASMYSACTRNRQESRFKLITAGSEEKVVGLHGIGYGVDEMIQGFAV 419 Query: 470 ALEYGASCEDIARVCHAHPTLSEAF 494 A++ GA+ D HPT SE F Sbjct: 420 AIKMGATKADFDATVAIHPTSSEEF 444 >4LA1-A nrPDB Length = 602 Score = 153 bits (386), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 127/445 (28%), Positives = 195/445 (43%), Gaps = 18/445 (4%) Query: 76 LGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALT 135 LGGTC+NVGCIP K + H ++ SE+ + M+E + + +L Sbjct: 156 LGGTCVNVGCIPKKLMHQAGLLSHSLEDAQHFGWSLDKSEISHDWSTMVEGVQSHIGSLN 215 Query: 136 GGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITI 195 G + N V ++N G + ++V T+ + I I++ATG E +P I Sbjct: 216 WGYKVSLRDNAVTYLNARGMLLSPHEVQITEKNKKVSTITGNKIILATG-ERPKYPEIPG 274 Query: 196 DEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDM 255 + ++S SL P K +V+GA + ++ LG DVT + + + G D Sbjct: 275 AIEYGITSDDLFSLPYFPGKTLVVGASYVALKCAGFLASLGGDVTVM--VRSILLRGFDQ 332 Query: 256 EISKNFQRILQKQGFKF-KL-------NTKVTGATKKSDGKIDVSIEAASGGKAEVITCD 307 ++++ ++ G KF KL K G + V G K E + Sbjct: 333 QMAEKVGDYMENHGVKFAKLCVPDEITQLKPVDTENNKPGLLLVKGHYTDGKKFEE-EFE 391 Query: 308 VLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAG-PMLAHKA 366 ++ +GR P L E +G++LD GR+ + QT + NIYAIGD+ AG P L A Sbjct: 392 TVIFAVGREPQLSKLNCEAVGVKLDKNGRVVCSDDEQTTVSNIYAIGDINAGKPQLTPVA 451 Query: 367 EDEGIICVEGMAGGAVHI-DYNCVPSVIYTHPEVAWVGKSEEQLKEE----GIEYKVGKF 421 G + GA + DY+ V + ++T E G SEE E+ IE F Sbjct: 452 IHAGRYLARRLFAGATELTDYSNVATTVFTPLEYGACGLSEEDAIEKYGDNDIEVYHSHF 511 Query: 422 PFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIA 481 + A + M + RVLG H+LGP AGE+ A+A++ GA+ ED Sbjct: 512 KPLEWTVAHREDNVCYMKLVCRISDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKEDFD 571 Query: 482 RVCHAHPTLSEAFREANLAASFGKS 506 R HPT SE F ++ G S Sbjct: 572 RTIGIHPTCSETFTTLHVTKRSGGS 596 >2HQM-A nrPDB Length = 479 Score = 152 bits (383), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 133/464 (28%), Positives = 218/464 (46%), Gaps = 25/464 (5%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHY-YHMA 101 D VIG G GG +A +AA G KT+ +E + LGGTC+NVGC+P K + S ++ Sbjct: 13 DYLVIGGGSGGVASARRAASYGAKTLLVEA-KALGGTCVNVGCVPKKVMWYASDLATRVS 71 Query: 102 HGKDFA---SRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITG 158 H ++ + ++ + N + +++ V L G ++ KV V G+ + Sbjct: 72 HANEYGLYQNLPLDKEHLTFNWPEFKQKRDAYVHRLNGIYQKNLEKEKVDVVFGWARFNK 131 Query: 159 KNQVTATKADGGTQVIDTKNILIATGSE-VTP--FPGITIDEDTIVSSTGALSLKKVPEK 215 V K D T+V +IL+ATG + + P PG + D S G L++ P+K Sbjct: 132 DGNVEVQKRDNTTEVYSANHILVATGGKAIFPENIPGFELGTD----SDGFFRLEEQPKK 187 Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 +VV+GAG IG+EL V+ LG++ V + G + + + Q + K +N Sbjct: 188 VVVVGAGYIGIELAGVFHGLGSETHLV-----IRGETVLRKFDECIQNTITDHYVKEGIN 242 Query: 276 TKVTGATKKSDGKIDVS-IEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPR 334 K + ++ ++ + D L+ IGR+ +G E +GI+L+ Sbjct: 243 VHKLSKIVKVEKNVETDKLKIHMNDSKSIDDVDELIWTIGRKSHL-GMGSENVGIKLNSH 301 Query: 335 GRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVH----IDYNCVP 390 +I + T +PNIY++GDVV L A G + G +DY VP Sbjct: 302 DQIIADEYQNTNVPNIYSLGDVVGKVELTPVAIAAGRKLSNRLFGPEKFRNDKLDYENVP 361 Query: 391 SVIYTHPEVAWVGKSE-EQLKEEGIE-YKVGKFPFAANSRAKTNADTDGMVKILGQKSTD 448 SVI++HPE +G SE E +++ G E KV F A A + + KI+ + Sbjct: 362 SVIFSHPEAGSIGISEKEAIEKYGKENIKVYNSKFTAMYYAMLSEKSPTRYKIVCAGPNE 421 Query: 449 RVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSE 492 +V+G HI+G + E++ +A++ GA+ D HPT +E Sbjct: 422 KVVGLHIVGDSSAEILQGFGVAIKMGATKADFDNCVAIHPTSAE 465 >2NVK-X nrPDB Length = 488 Score = 151 bits (382), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 133/476 (27%), Positives = 220/476 (46%), Gaps = 35/476 (7%) Query: 41 DADVTVIGSGPGGYVAAIKAAQLGFKTVCIE---KNETLG------GTCLNVGCIPSKAL 91 D D+ VIG G G A +A G + C++ TLG GTC+NVGCIP K + Sbjct: 9 DYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKKLM 68 Query: 92 LNNSHYYHMAHGKDFASRGIEMSE-VRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHV 150 S H + A+ G + + ++ + K+++ +K++ + KV ++ Sbjct: 69 HQASLLGEAVH--EAAAYGWNVDDKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKKVEYI 126 Query: 151 NGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLK 210 NG G + + A K G + I + +IA G +P I + ++S SL Sbjct: 127 NGLGSFVDSHTLLA-KLKSGERTITAQTFVIAVGGRPR-YPDIPGAVEYGITSDDLFSLD 184 Query: 211 KVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGF 270 + P K +V+GAG IG+E + LG + T + + + G D ++++ ++++G Sbjct: 185 REPGKTLVVGAGYIGLECAGFLKGLGYEPTVM--VRSIVLRGFDQQMAELVAASMEERGI 242 Query: 271 KFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIE 330 F T K+ DGK+ V + G+ D +L IGR+ +L L G+ Sbjct: 243 PFLRKTVPLSVEKQDDGKLLVKYKNVETGEESEDVYDTVLWAIGRKGLVDDLNLPNAGVT 302 Query: 331 LDPRGRIPVNTRFQTKIPNIYAIGDVVAG-PMLAHKAEDEGIICVEGMAGGAVH-IDYNC 388 + + +IPV+++ T + NIYA+GD++ G P L A G + + GG+ +DY Sbjct: 303 VQ-KDKIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYKD 361 Query: 389 VPSVIYTHPEVAWVGKSEE----QLKEEGIE-----YKVGKFPFAANSRAKTNADTDGMV 439 V + ++T E A VG SEE Q + IE YK +F S + Sbjct: 362 VATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQKSVRYC------YL 415 Query: 440 KILGQKSTD-RVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAF 494 K + ++ D RV G H +GP AGE++ A AL+ G + + HPT +E F Sbjct: 416 KAVAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEF 471 >5W1J-A nrPDB Length = 584 Score = 150 bits (379), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 132/449 (29%), Positives = 201/449 (44%), Gaps = 29/449 (6%) Query: 76 LGGTCLNVGCIPSK-----ALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTA 130 LGGTC+NVGCIP K ALLN HY M K F G ++ + + KM+E Sbjct: 146 LGGTCVNVGCIPKKLMHQAALLN--HY--MEDAKSF---GWDVDKGPHDWVKMVEGIQDH 198 Query: 131 VKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPF 190 + AL G V ++N G+I + + T G + I T I++ATG E + Sbjct: 199 IHALNFGYRSSMMNANVKYLNALGEIVDPHTIKTTNKQGIVKNITTNTIIVATG-ERPRY 257 Query: 191 PGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGG 250 P I ++ ++S +L P K + +GA + +E +G DVT + + + Sbjct: 258 PPIPGAKEYGITSDDLFTLDHNPGKTLCVGASYVSLECAGFLSSIGCDVTVM--VRSIFL 315 Query: 251 VGIDMEISKNFQRILQKQGFKF-----KLNTKVTGATKKSDGKIDV-SIEAA-SGGKAEV 303 G D +++ + K G KF + + GK+ + +E G Sbjct: 316 RGFDQQMAGLISDYIAKYGVKFVRPCVPTSVRCLEEYDPESGKLAIYEVEGKHEDGTPFK 375 Query: 304 ITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVV-AGPML 362 T + +L +GR P T N+GL+ + ++ GR+ V+ +T +PNIYAIGDV AG L Sbjct: 376 DTFNTVLFAVGRDPCTTNIGLQNVDVKTT-NGRVVVDDEERTNVPNIYAIGDVSNAGYQL 434 Query: 363 AHKAEDEGIICVEGM-AGGAVHIDYNCVPSVIYTHPEVAWVGKSEE----QLKEEGIEYK 417 A G + DY VP+ ++T E +G SEE + E+ IE Sbjct: 435 TPLAIQAGKNLARRLYTADDCRTDYTNVPTTVFTPLEYGCIGLSEENAISKFGEDNIEVF 494 Query: 418 VGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASC 477 F + +T I+ ++ +RV+G H+ GP AGE+ A+A+ GA Sbjct: 495 HSYFQPLEWTVPHRPDNTCYAKLIINKQDDNRVVGFHVFGPNAGEVTQGYAVAMHLGARK 554 Query: 478 EDIARVCHAHPTLSEAFREANLAASFGKS 506 ED R HPT SE F + S G S Sbjct: 555 EDFDRTIGIHPTCSETFTTLRVTKSSGAS 583 >5VDN-A nrPDB Length = 463 Score = 150 bits (378), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 121/442 (27%), Positives = 204/442 (46%), Gaps = 23/442 (5%) Query: 59 KAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH--GKDFASRGIEMSEV 116 +AA G K IE + LGGTC+NVGC+P K + + + H G D+ G + + Sbjct: 35 RAAMYGKKCALIEAKQ-LGGTCVNVGCVPKKVMWHAAQIAEAIHLYGPDY---GFDTTVN 90 Query: 117 RLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDT 176 + K++ ++ + + NKV + G+ + V A + + I Sbjct: 91 HFDWKKLIANRTAYIDRIHQSYERGLGNNKVDVIQGFARF-----VDAHTVEVNGETITA 145 Query: 177 KNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLG 236 +ILIATG + P I E I S G L ++P+++ V+GAG I VE+ V LG Sbjct: 146 DHILIATGGRPS-HPDIPGAEYGI-DSDGFFELDEMPKRVAVVGAGYIAVEIAGVLNGLG 203 Query: 237 ADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAA 296 + T + H D I + ++ +G K + K +DG + + +E Sbjct: 204 TE-THLFVRKHAPLRTFDPLIVETLLEVMNTEGPKLHTESVPKAVIKNADGSLTLQLENG 262 Query: 297 SGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDV 356 + +T D L+ IGR P T NL L G++ + +G I V+ T + IYA+GD Sbjct: 263 TE-----VTVDHLIWAIGREPATDNLNLSVTGVKTNDKGYIEVDKFQNTNVKGIYAVGDN 317 Query: 357 VAGPMLAHKAEDEGIICVEGMAGGAV--HIDYNCVPSVIYTHPEVAWVGKSEEQLKEE-- 412 L A G E + H+DY+ +P+V+++HP + +G +E Q +E+ Sbjct: 318 TGVVELTPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIGTIGLTEPQAREKFG 377 Query: 413 GIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALE 472 + KV F A A T +K++ + ++++G H +G G E++ A+A++ Sbjct: 378 DDQVKVYTSSFTAMYSAVTQHRQPCRMKLVCVGAEEKIVGIHGIGFGMDEILQGFAVAMK 437 Query: 473 YGASCEDIARVCHAHPTLSEAF 494 GA+ +D HPT +E F Sbjct: 438 MGATKKDFDNTVAIHPTAAEEF 459 >4B1B-A nrPDB Length = 542 Score = 147 bits (372), Expect = 8e-36, Method: Compositional matrix adjust. Identities = 148/508 (29%), Positives = 230/508 (45%), Gaps = 54/508 (10%) Query: 37 DQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET--------LGGTCLNVGCIPS 88 + D D VIG GPGG +A +AA G + + + + +GGTC+NVGC+P Sbjct: 38 EHTYDYDYVVIGGGPGGMASAKEAAAHGARVLLFDYVKPSSQGTKWGIGGTCVNVGCVPK 97 Query: 89 KALLNNSHYY-HMA--HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQN 145 K + HY HM D + G + ++ + K++ + +++L + + Sbjct: 98 KLM----HYAGHMGSIFKLDSKAYGWKFDNLKHDWKKLVTTVQSHIRSLNFSYMTGLRSS 153 Query: 146 KVVHVNGYGKITGKNQVTA-TKAD-GGTQVIDTKNILIATGSEVTPFPGITID----EDT 199 KV ++NG K+ KN V+ K D + + K ILIATG P I D ++ Sbjct: 154 KVKYINGLAKLKDKNTVSYYLKGDLSKEETVTGKYILIATGCR----PHIPDDVEGAKEL 209 Query: 200 IVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISK 259 ++S SLKK P K +V+GA + +E LG DVT + + G D + + Sbjct: 210 SITSDDIFSLKKDPGKTLVVGASYVALECSGFLNSLGYDVTVA--VRSIVLRGFDQQCAV 267 Query: 260 NFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFT 319 + +++QG FK N + K D KI V S +E+ D +L IGR+ Sbjct: 268 KVKLYMEEQGVMFK-NGILPKKLTKMDDKILVEF---SDKTSELY--DTVLYAIGRKGDI 321 Query: 320 KNLGLEELGIELD-PRGRIPVNTRFQTKIPNIYAIGDVVAG-PMLAHKAEDEGIICVEGM 377 L LE L + ++ +I + T IP+I+A+GDV P LA A G I + Sbjct: 322 DGLNLESLNMNVNKSNNKIIADHLSCTNIPSIFAVGDVAENVPELAPVAIKAGEILARRL 381 Query: 378 AGGAVHI-DYNCVPSVIYTHPEVAWVGKSEEQLKE----EGIEYKVGKF---PFAANSRA 429 + I DY+ +P+ IYT E G SEE+ E +E + +F +A R Sbjct: 382 FKDSDEIMDYSYIPTSIYTPIEYGACGYSEEKAYELYGKSNVEVFLQEFNNLEISAVHRQ 441 Query: 430 K----------TNADTDGMVKILGQKSTD-RVLGAHILGPGAGEMVNEAALALEYGASCE 478 K + + + K++ K+ D RV+G H +GP AGE+ ALAL + Sbjct: 442 KHIRAQKDEYDLDVSSTCLAKLVCLKNEDNRVIGFHYVGPNAGEVTQGMALALRLKVKKK 501 Query: 479 DIARVCHAHPTLSEAFREANLAASFGKS 506 D HPT +E+F + S G S Sbjct: 502 DFDNCIGIHPTDAESFMNLFVTISSGLS 529 >4DNA-A nrPDB Length = 463 Score = 147 bits (371), Expect = 1e-35, Method: Compositional matrix adjust. Identities = 121/457 (26%), Positives = 205/457 (44%), Gaps = 20/457 (4%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYH 99 D D+ VIG G GG + AA LG K V I + GGTC+ GC+P K + S + Sbjct: 4 FDYDLFVIGGGSGGVRSGRLAAALG-KKVAIAEEFRYGGTCVIRGCVPKKLYVYASQFAE 62 Query: 100 MAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGK 159 H +D A G + E R + K++ K + L G ++ ++ G Sbjct: 63 --HFEDAAGFGWTVGESRFDWAKLVAAKEQEIARLEGLYRKGLANAGAEILDTRAELAGP 120 Query: 160 NQVTATKADGGTQVIDTKNILIATGSEVTP---FPGITIDEDTIVSSTGALSLKKVPEKM 216 N V K + + + I+IA G +P PG + ++S A L +PE + Sbjct: 121 NTV---KLLASGKTVTAERIVIAVGGHPSPHDALPG----HELCITSNEAFDLPALPESI 173 Query: 217 VVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNT 276 ++ G G I VE +++ LG T + + G D ++ + ++++G + Sbjct: 174 LIAGGGYIAVEFANIFHGLGVKTTLI-YRGKEILSRFDQDMRRGLHAAMEEKGIRILCED 232 Query: 277 KVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGR 336 + + +DG+ A+ K I D +++ +GR P T LGLE G+ + G Sbjct: 233 IIQSVSADADGR-----RVATTMKHGEIVADQVMLALGRMPNTNGLGLEAAGVRTNELGA 287 Query: 337 IPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEG-MAGGAVHIDYNCVPSVIYT 395 I V+ +T P IYA+GDV L A E + +E D++ + + +++ Sbjct: 288 IIVDAFSRTSTPGIYALGDVTDRVQLTPVAIHEAMCFIETEYKNNPTSPDHDLIATAVFS 347 Query: 396 HPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHI 455 PE+ VG +EE+ + E +V + F + ++K++ + +V+GAHI Sbjct: 348 QPEIGTVGITEEEAARKFQEIEVYRAEFRPMKATLSGRKEKTIMKLVVNAADRKVVGAHI 407 Query: 456 LGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSE 492 LG AGEM ++L G + +D R HPT +E Sbjct: 408 LGHDAGEMAQLLGISLRAGCTKDDFDRTMAVHPTAAE 444 >3IC9-A nrPDB Length = 492 Score = 143 bits (360), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 128/476 (26%), Positives = 215/476 (45%), Gaps = 38/476 (7%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSH-YY 98 I+ DV +IG+G G + A +AA+ V + + G TC VGC+PSK L+ + Y Sbjct: 7 INVDVAIIGTGTAG-MGAYRAAKKHTDKVVLIEGGAYGTTCARVGCMPSKLLIAAADASY 65 Query: 99 HMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTG----GIAHLFKQNKVVHVNGYG 154 H + F GI++ + +N +M++ T G + +Q+K+ G+ Sbjct: 66 HASQTDLF---GIQVDRISVNGKAVMKRIQTERDRFVGFVVESVESFDEQDKI---RGFA 119 Query: 155 KITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPE 214 K ++ + + D +QVI K I+IATGS + ++++ L +P+ Sbjct: 120 KFLDEHTL---QVDDHSQVI-AKRIVIATGSRPNYPEFLAAAGSRLLTNDNLFELNDLPK 175 Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVG--IDMEISKNFQRILQKQGFKF 272 + V G GVIG+ELG RLG V+ G G V D E+ + ++ ++ F F Sbjct: 176 SVAVFGPGVIGLELGQALSRLG---VIVKVFGRSGSVANLQDEEMKRYAEKTFNEE-FYF 231 Query: 273 KLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELD 332 +V +K D ++V SG K + +L GR+ LGLE IELD Sbjct: 232 DAKARVISTIEKEDA-VEVIYFDKSGQKT-TESFQYVLAATGRKANVDKLGLENTSIELD 289 Query: 333 PRGRIPV--NTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHI----DY 386 + P+ QT + +I+ GD L H+A D+G + G GA + Sbjct: 290 KKNS-PLFDELTLQTSVDHIFVAGDANNTLTLLHEAADDGKVA--GTNAGAYPVIAQGQR 346 Query: 387 NCVPSVIYTHPEVAWVGKSEEQLK-----EEGIEYKVGKFPFAANSRAKTNADTDGMVKI 441 SV++T P+VA VG S Q++ ++ Y VG+ F R++ G++ + Sbjct: 347 RAPLSVVFTEPQVASVGLSLRQIEDLYADQDAANYVVGQVSFEGQGRSRVMGKNKGLLNV 406 Query: 442 LGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREA 497 +++ LGA + GP A + + A A + + + + + HP + E R A Sbjct: 407 YADRTSGEFLGAEMFGPAAEHIGHLLAWARQQQMTVQAMLTMPFYHPVIEEGLRTA 462 >3O0H-A nrPDB Length = 484 Score = 142 bits (359), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 117/463 (25%), Positives = 213/463 (46%), Gaps = 33/463 (7%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYH 99 D D+ VIGSG GG AA A LG K V I + +GGTC+ GC+P K ++Y Sbjct: 25 FDFDLFVIGSGSGGVRAARLAGALG-KRVAIAEEYRIGGTCVIRGCVPKKL-----YFYA 78 Query: 100 MAHGKDFASR---GIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFK---QNKVVHVNGY 153 + ++F+ G + ++ N +K++ K+ + L G L++ QN VH+ Sbjct: 79 SQYAQEFSKSIGFGWKYADPIFNWEKLVAAKNKEISRLEG----LYREGLQNSNVHIYES 134 Query: 154 GKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVP 213 + G + I + ILIATG+++ I D ++S L+K+P Sbjct: 135 RAVFVDEHTLELSVTG--ERISAEKILIATGAKIVSNSAIK-GSDLCLTSNEIFDLEKLP 191 Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGV---GIDMEISKNFQRILQKQGF 270 + +V++G G IGVE +++ LG T L H G + D ++ + + +G Sbjct: 192 KSIVIVGGGYIGVEFANIFHGLGVKTT----LLHRGDLILRNFDYDLRQLLNDAMVAKGI 247 Query: 271 KFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIE 330 V+ + ++ +V + + I D +++ GR P T LGLE G++ Sbjct: 248 SIIYEATVS-QVQSTENCYNVVLT-----NGQTICADRVMLATGRVPNTTGLGLERAGVK 301 Query: 331 LDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVE-GMAGGAVHIDYNCV 389 ++ G + V+ + T + +I+A+GDV L A + + V+ + DY+ + Sbjct: 302 VNEFGAVVVDEKMTTNVSHIWAVGDVTGHIQLTPVAIHDAMCFVKNAFENTSTTPDYDLI 361 Query: 390 PSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDR 449 + +++ PE+ VG SEE ++ + F + + +K++ + Sbjct: 362 TTAVFSQPEIGTVGLSEEDALHRYKRVEIYRTVFRPMRNVLSGSPEKMFMKLVVDGESRI 421 Query: 450 VLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSE 492 V+GAH+LG AGE+ ++L+ + + + HPT+SE Sbjct: 422 VVGAHVLGENAGEIAQLIGISLKGKLTKDIFDKTMAVHPTMSE 464 >4NEW-A nrPDB Length = 492 Score = 141 bits (355), Expect = 8e-34, Method: Compositional matrix adjust. Identities = 133/477 (27%), Positives = 215/477 (45%), Gaps = 44/477 (9%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNE---------TLGGTCLNVGCIPSKALLN 93 D+ VIG+G GG AA AA L K V + + LGGTC+NVGC+P K ++ Sbjct: 7 DLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGTCVNVGCVPKKLMVT 66 Query: 94 NSHYYHMAHGKDFASRGIEM--SEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNK-VVHV 150 + Y M H ++ A G E + +R ++ K AV + +F+ + + Sbjct: 67 GAQY--MEHLRESAGFGWEFDRTTLRAEWKNLIAVKDEAVLNINKSYDEMFRDTEGLEFF 124 Query: 151 NGYGKITGKNQV----TATKADGGTQVIDTKNILIATGS--EVTPFPGITIDEDTIVSST 204 G+G + KN V +A A + ++T++IL+A+GS + PGI + +SS Sbjct: 125 LGWGSLESKNVVNVRESADPASAVKERLETEHILLASGSWPHMPNIPGI----EHCISSN 180 Query: 205 GALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVE--FLGHVGGVGIDMEISKNFQ 262 A L + P +++ +G G I VE ++ V + G + G D + + Sbjct: 181 EAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPKDGQVTLCYRGEMILRGFDHTLREELT 240 Query: 263 RILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNL 322 + L G + +DG V+ E SG K + D++++ IGR P TK+L Sbjct: 241 KQLTANGIQILTKENPAKVELNADGSKSVTFE--SGKKMDF---DLVMMAIGRSPRTKDL 295 Query: 323 GLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAV 382 L+ G+ + G + V+ +T + NIYAIGDV ML A +E V+ + G Sbjct: 296 QLQNAGVMIK-NGGVQVDEYSRTNVSNIYAIGDVTNRVMLTPVAINEAAALVDTVFGTTP 354 Query: 383 H-IDYNCVPSVIYTHPEVAWVGKSEE--QLKEEGIEYKVGKF-PF---AANSRAKTNADT 435 D+ V S +++ P + G EE + E + + F P + S+ KT Sbjct: 355 RKTDHTRVASAVFSIPPIGTCGLIEEVASKRYEVVAVYLSSFTPLMHKVSGSKYKT---- 410 Query: 436 DGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSE 492 + KI+ S VLG H+LG A E++ + L+ A D HPT +E Sbjct: 411 -FVAKIITNHSDGTVLGVHLLGDNAPEIIQGIGICLKLNAKISDFYNTIGVHPTSAE 466 >1XDI-A nrPDB Length = 499 Score = 134 bits (336), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 118/463 (25%), Positives = 206/463 (44%), Gaps = 16/463 (3%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKT--VCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMA 101 + ++G GP GY AA+ AA +T V + + +GG + C+PSK + ++ Sbjct: 5 IVILGGGPAGYEAALVAATSHPETTQVTVIDCDGIGGAAVLDDCVPSKTFIASTGLRTEL 64 Query: 102 HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKIT---- 157 I+ + +++L ++ + T A + I V + G G++ Sbjct: 65 RRAPHLGFHIDFDDAKISLPQIHARVKTLAAAQSADITAQLLSMGVQVIAGRGELIDSTP 124 Query: 158 --GKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEK 215 ++++ AT ADG T + +L+ATG+ P D + I++ L +P+ Sbjct: 125 GLARHRIKATAADGSTSEHEADVVLVATGASPRILPSAQPDGERILTWRQLYDLDALPDH 184 Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 ++V+G+GV G E + LG VT V HV D + + + ++G + N Sbjct: 185 LIVVGSGVTGAEFVDAYTELGVPVTVVASQDHVLPYE-DADAALVLEESFAERGVRLFKN 243 Query: 276 TKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRG 335 + T+ G V + G E L+ IG P T LGLE +GI+L Sbjct: 244 ARAASVTRTGAG---VLVTMTDGRTVE---GSHALMTIGSVPNTSGLGLERVGIQLGRGN 297 Query: 336 RIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICV-EGMAGGAVHIDYNCVPSVIY 394 + V+ +T IYA GD LA A +G I + + G I V + ++ Sbjct: 298 YLTVDRVSRTLATGIYAAGDCTGLLPLASVAAMQGRIAMYHALGEGVSPIRLRTVAATVF 357 Query: 395 THPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAH 454 T PE+A VG + + + + P N+RAK + G VKI ++ST V+G Sbjct: 358 TRPEIAAVGVPQSVIDAGSVAARTIMLPLRTNARAKMSEMRHGFVKIFCRRSTGVVIGGV 417 Query: 455 ILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREA 497 ++ P A E++ A+A++ + ++A+ +P+LS + EA Sbjct: 418 VVAPIASELILPIAVAVQNRITVNELAQTLAVYPSLSGSITEA 460 >5U1O-A nrPDB Length = 458 Score = 132 bits (333), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 122/449 (27%), Positives = 201/449 (44%), Gaps = 36/449 (8%) Query: 59 KAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNS------HYYHMAHGKDFASRGIE 112 +AA G K IE + LGGTC+NVGC+P K + + + + Y +G D +G + Sbjct: 29 RAAMYGAKVALIEAQD-LGGTCVNVGCVPKKVMWHGAQIAEAMNLYAEDYGFDVDVKGFD 87 Query: 113 MSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQ 172 S K++E + + + + NKV + G+ K + V + +G Sbjct: 88 WS-------KLVESRQAYIGRIHQSYDRVLGNNKVNVIKGFAKFVDEKTV---EVNGEHY 137 Query: 173 VIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVW 232 D +ILIA G T P I E I S G L + P+++ V+GAG I VE+ V Sbjct: 138 TAD--HILIAVGGRPT-IPNIPGAEYGI-DSNGFFDLAEQPKRVAVVGAGYIAVEIAGVL 193 Query: 233 QRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVS 292 LG + T + D I +++ +G ++ K++DG + + Sbjct: 194 HALGTE-THLFVRKESPLRSFDPMIIDTLVEVMEAEGPTLHTHSVPKEVVKEADGSLTLH 252 Query: 293 IEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYA 352 +E E D L+ IGR P T + L G+ + +G I V+ +T + IY Sbjct: 253 LE-----NGESQNVDQLIWAIGRHPATDAINLASTGVATNEKGYIKVDEYQETNVKGIYC 307 Query: 353 IGDVVAGPM-LAHKAEDEGIICVEGMAGGA--VHIDYNCVPSVIYTHPEVAWVG----KS 405 +GD++ G + L A G E + +DY+ VP+V+++HP + +G ++ Sbjct: 308 VGDIMEGGIELTPVAVKAGRQLSERLFNNKPNAKMDYDLVPTVVFSHPPIGTIGLTTQEA 367 Query: 406 EEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVN 465 EE+ ++ I KV F A A T +K++ + V+G H +G EM+ Sbjct: 368 EEKYGKDNI--KVYTSGFTAMYTAVTKHRQPCKMKLVCAGEEETVVGLHGIGFTVDEMIQ 425 Query: 466 EAALALEYGASCEDIARVCHAHPTLSEAF 494 +A++ GA+ D V HPT SE F Sbjct: 426 GFGVAMKMGATKADFDSVVAIHPTGSEEF 454 >5V36-A nrPDB Length = 453 Score = 130 bits (327), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 121/442 (27%), Positives = 189/442 (42%), Gaps = 23/442 (5%) Query: 59 KAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRL 118 +AA G K + E + +GGTC+NVGC+P K + + + A G +++ Sbjct: 25 RAAMHGAKVILFEGKQ-VGGTCVNVGCVPKKVMWYGAQVAETINNYA-ADYGFDVTTQAF 82 Query: 119 NLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKN 178 + D + + + + + F N V V GY V A + + + Sbjct: 83 HFDVLKQNRQAYIDRIHDSYERGFDSNGVERVYGYATF-----VDAHTVEVAGEHYTAPH 137 Query: 179 ILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGAD 238 ILIATG P I E I +S G L +P++ V+GAG I VE+ + LG++ Sbjct: 138 ILIATGGHAL-LPDIPGSEYGI-TSDGFFELDAIPKRTAVVGAGYIAVEISGILHALGSE 195 Query: 239 VTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASG 298 T + D EI ++K G + K +D + + +E Sbjct: 196 -THLFVRRDRPLRKFDKEIVGTLVDEMKKDGPHLHTFSVPKEVIKNTDNSLTLILE---- 250 Query: 299 GKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVA 358 E T D L+ IGR TK LE G+ LD RG I + T + +YA+GDV Sbjct: 251 -NGEEYTVDTLIWAIGRAANTKGFNLEVTGVTLDSRGFIATDAFENTNVEGLYALGDVNG 309 Query: 359 GPMLAHKAEDEGIICVEGMAGG--AVHIDYNCVPSVIYTHPEVAWVGKSEE----QLKEE 412 L A G E + +DY V +VI++HP + +G SEE Q EE Sbjct: 310 KLELTPVAVKAGRQLSERLFNHKPQAKMDYKDVATVIFSHPVIGSIGLSEEAALDQYGEE 369 Query: 413 GIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALE 472 + V + F + A T+ +K++ ++++G H +G G EM+ A+A++ Sbjct: 370 NV--TVYRSTFTSMYTAVTSHRQACKMKLVTVGEDEKIVGLHGIGYGVDEMIQGFAVAIK 427 Query: 473 YGASCEDIARVCHAHPTLSEAF 494 GA+ D HPT SE F Sbjct: 428 MGATKADFDNTVAIHPTGSEEF 449 >1ONF-A nrPDB Length = 500 Score = 117 bits (293), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 122/479 (25%), Positives = 214/479 (44%), Gaps = 63/479 (13%) Query: 66 KTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMME 125 K +EK+ LGGTC+NVGC+P K + N + + + + S NL ++E Sbjct: 27 KVALVEKSR-LGGTCVNVGCVPKKIMFNAASVHDILENSRHYGFDTKFS---FNLPLLVE 82 Query: 126 QKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQV-------TATKADG--GTQVIDT 176 ++ ++ L ++KV G +N++ K +G ++++ Sbjct: 83 RRDKYIQRLNNIYRQNLSKDKVDLYEGTASFLSENRILIKGTKDNNNKDNGPLNEEILEG 142 Query: 177 KNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLG 236 +NILIA G++ FP + E+TI SS ++K+ +K+ ++G+G I VEL +V +RLG Sbjct: 143 RNILIAVGNKPV-FPPVKGIENTI-SSDEFFNIKE-SKKIGIVGSGYIAVELINVIKRLG 199 Query: 237 ADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAA 296 D + + G+ D + + ++K V K SD ++SI + Sbjct: 200 ID-SYIFARGNRILRKFDESVINVLENDMKKNNINIVTFADVVEIKKVSDK--NLSIHLS 256 Query: 297 SGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGD- 355 G E D ++ C+GR P T+NL LE+L +E + I V+ +T + NIYA+GD Sbjct: 257 DGRIYE--HFDHVIYCVGRSPDTENLKLEKLNVETN-NNYIVVDENQRTSVNNIYAVGDC 313 Query: 356 ----------------VVAGPMLAHKAED--EGIICVEGMAGGAVH-------------- 383 + +K E+ E I + A++ Sbjct: 314 CMVKKSKEIEDLNLLKLYNEERYLNKKENVTEDIFYNVQLTPVAINAGRLLADRLFLKKT 373 Query: 384 --IDYNCVPSVIYTHPEVAWVGKSEE---QLK-EEGIEYKVGKFP--FAANSRAKTNADT 435 +Y +P+VI++HP + +G SEE Q+ +E ++ KF F + + Sbjct: 374 RKTNYKLIPTVIFSHPPIGTIGLSEEAAIQIYGKENVKIYESKFTNLFFSVYDIEPELKE 433 Query: 436 DGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAF 494 +K++ + + G HI+G A E+V A+AL+ A+ +D HPT +E F Sbjct: 434 KTYLKLVCVGKDELIKGLHIIGLNADEIVQGFAVALKMNATKKDFDETIPIHPTAAEEF 492 >3Q6J-A nrPDB Length = 523 Score = 107 bits (267), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 108/472 (22%), Positives = 197/472 (41%), Gaps = 44/472 (9%) Query: 37 DQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSH 96 + P + D IG G G + +G + + +++ LGG+C + C+P + + Sbjct: 39 NDPREYDAIFIGGGAAGRFGSAYLRAMGGRQLIVDRWPFLGGSCPHNACVPHHLFSDCAA 98 Query: 97 YYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQ--NKVVHVNGYG 154 +A +M+E + + ++++ G + K+ N +N Sbjct: 99 ELMLARTFSGQYWFPDMTEKVVGIKEVVDLFRAGRNGPHGIMNFQSKEQLNLEYILNCPA 158 Query: 155 KITGKNQVTATKADGGTQVIDTKNILIATGSE--VTPFPGIT----IDEDTIVSSTGALS 208 K+ + V A +V KN+++A G+ PG+ D T+V Sbjct: 159 KVIDNHTVEAAG-----KVFKAKNLILAVGAGPGTLDVPGVNAKGVFDHATLVEE----- 208 Query: 209 LKKVP-EKMVVIGAGVIGVELGSVWQRLGADVTAV---EFLGHVGGVGIDMEISKNFQRI 264 L P +VV+G VE G + G + E L + D E Sbjct: 209 LDYEPGSTVVVVGGSKTAVEYGCFFNATGRRTVMLVRTEPLKLIK----DNETRAYVLDR 264 Query: 265 LQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGL 324 +++QG + + VT + ++G++ + G+ + T D + + +G +P + L Sbjct: 265 MKEQGMEIISGSNVTRIEEDANGRVQAVVAMTPNGEMRIET-DFVFLGLGEQPRSAELA- 322 Query: 325 EELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHI 384 + LG++L P+G + VN QT +PN+YA+GD++ GPM KA G + G + Sbjct: 323 KILGLDLGPKGEVLVNEYLQTSVPNVYAVGDLIGGPMEMFKARKSGCYAARNVMGEKISY 382 Query: 385 DYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFP----------FAANSRA----- 429 P ++TH EV+++G EE+ + G E K P A+ R Sbjct: 383 TPKNYPDFLHTHYEVSFLGMGEEEARAAGHEIVTIKMPPDTENGLNVALPASDRTMLYAF 442 Query: 430 -KTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDI 480 K A G KI+ T +VLGAH +G GA + + ++ G + +++ Sbjct: 443 GKGTAHMSGFQKIVIDAKTRKVLGAHHVGYGAKDAFQYLNVLIKQGLTVDEL 494 >5JCN-A nrPDB Length = 451 Score = 63.2 bits (152), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 73/309 (23%), Positives = 124/309 (40%), Gaps = 47/309 (15%) Query: 106 FASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTAT 165 ++ +GIE L L + + A K LT + F ++ G I Sbjct: 99 YSEKGIE-----LILSTEIVKADLASKTLTSAVGATFTYEILIIATGSSVIK-------- 145 Query: 166 KADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIG 225 +D GTQ D+ NIL EV D D +V++ A K K V++G G IG Sbjct: 146 LSDFGTQGADSNNILYL--REVD-------DADKLVAAIQA----KKGGKAVIVGGGYIG 192 Query: 226 VELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKS 285 +EL + + DVT V +I+ ++ +G K T G + Sbjct: 193 LELSAALKINDFDVTMVFPEPWCMPRLFTADIAAFYESYYTNKGVKIVKGTVAVGFDADA 252 Query: 286 DGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQT 345 +G + A + V+ D+++V +G RP T G + +G I + F+T Sbjct: 253 NG----DVTAVNLKNGSVLEADIVVVGVGGRPLTTLFK----GQVAEEKGGIKTDAFFET 304 Query: 346 KIPNIYAIGDVVAGPML-------------AHKAEDEGIICVEGMAGGAVHIDYNCVPSV 392 +P +YA+GDV PM A K+ ++ + ++G G ++Y+ +P Sbjct: 305 SVPGVYAVGDVATFPMKMYNELRRVEHVDHARKSAEQAVKAIKGKESGESVVEYDYLPYF 364 Query: 393 IYTHPEVAW 401 ++ W Sbjct: 365 FSRSFDLGW 373 >3ICS-A nrPDB Length = 588 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 84/324 (25%), Positives = 136/324 (41%), Gaps = 50/324 (15%) Query: 210 KKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQG 269 +K P VIG G IGVE+ + G +VT VE V ID E++ ++ Sbjct: 184 EKKPRHATVIGGGFIGVEMVENLRERGIEVTLVEMANQVMP-PIDYEMAAYVHEHMKNHD 242 Query: 270 FKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRP---FTKNLGLEE 326 + V + +G + V +++ S VI D+L++ IG +P K GL Sbjct: 243 VELVFEDGVDAL--EENGAV-VRLKSGS-----VIQTDMLILAIGVQPESSLAKGAGLA- 293 Query: 327 LGIELDPRGRIPVNTRFQTKIPNIYAIGDVV---------------------AGPMLAHK 365 LG+ RG I VN +FQT P+IYAIGD + G MLA Sbjct: 294 LGV----RGTIKVNEKFQTSDPHIYAIGDAIEVKDFVTETETMIPLAWPANRQGRMLADI 349 Query: 366 AEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAA 425 +G G +V ++ VA G +E+ LK I Y+V + Sbjct: 350 IHGHTDSLYKGTLGTSVAKVFDLT---------VATTGLNEKILKRLNIPYEVVHVQANS 400 Query: 426 NSRAKTNADTDGMVKILGQKSTDRVLGAHILG-PGAGEMVNEAALALEYGASCEDIARVC 484 ++ NA T ++K++ K + ++ GA LG G + ++ A A++ + D+ + Sbjct: 401 HAGYYPNA-TPVLIKLIFNKDSGKIYGAQTLGRDGVDKRMDVIATAIKANLTVLDLPDLE 459 Query: 485 HAH-PTLSEAFREANLAASFGKSI 507 ++ P S A N+ +I Sbjct: 460 LSYAPPYSSAKDPVNMVGYAASNI 483 >4GCM-A nrPDB Length = 312 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 90/330 (27%), Positives = 130/330 (39%), Gaps = 68/330 (20%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYH 99 ID D+ +IG+GP G AA+ A++ KTV IE+ + G + + + N + Sbjct: 5 IDFDIAIIGAGPAGMTAAVYASRANLKTVMIERG-------IPGGQMANTEEVENFPGFE 57 Query: 100 MAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKIT-- 157 M G D ++ KM E A G + + K V G K+ Sbjct: 58 MITGPDLST-------------KMFEH------AKKFGAVYQYGDIKSVEDKGEYKVINF 98 Query: 158 GKNQVTATKADGGTQVIDTKNILIATGSEVTPF--PGITIDEDTIVS----STGALSLKK 211 G ++TA K ++IATG+E PG VS GA K Sbjct: 99 GNKELTA------------KAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKNK 146 Query: 212 VPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFK 271 ++ VIG G VE G+ + VT V + QRILQ + FK Sbjct: 147 ---RLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDEL-----------RAQRILQDRAFK 192 Query: 272 FKLNTKVTGATKKS----DGKI-DVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEE 326 + T KS DGK+ V++ + G E D + + IG +P T ++ Sbjct: 193 NDKIDFIWSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAP--FKD 250 Query: 327 LGIELDPRGRIPVNTRFQTKIPNIYAIGDV 356 LGI D G I T +P I+A GDV Sbjct: 251 LGITNDV-GYIVTKDDMTTSVPGIFAAGDV 279 >3IWA-A nrPDB Length = 472 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 56/179 (31%), Positives = 82/179 (45%), Gaps = 24/179 (13%) Query: 191 PGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELG-SVWQRLGADVTAVEFLGHVG 249 P +DE V A+S +V K V++G G IG+E+ S+ G D T VE + Sbjct: 140 PVTNLDEAEFVQH--AISAGEV-SKAVIVGGGFIGLEMAVSLADMWGIDTTVVELADQIM 196 Query: 250 GVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVIT---- 305 +S+ + L+K KV V +E +G A VIT Sbjct: 197 PGFTSKSLSQMLRHDLEKNDVVVHTGEKV------------VRLEGENGKVARVITDKRT 244 Query: 306 --CDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPML 362 D++++ G P T+ + G+ELDPRG I V+TR +T P+I+A GD V P L Sbjct: 245 LDADLVILAAGVSPNTQLA--RDAGLELDPRGAIIVDTRMRTSDPDIFAGGDCVTIPNL 301 >1YQZ-A nrPDB Length = 438 Score = 59.3 bits (142), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 42/144 (29%), Positives = 79/144 (54%), Gaps = 15/144 (10%) Query: 214 EKMVVIGAGVIGVE-LGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKF 272 +K++V+GAG + +E L ++++R G T + + + +D ++++ L K+ + Sbjct: 149 DKVLVVGAGYVSLEVLENLYER-GLHPTLIHRSDKINKL-MDADMNQPILDELDKREIPY 206 Query: 273 KLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELD 332 +LN ++ I+ + GK E D+++ +G P +K +E I+LD Sbjct: 207 RLNEEINA--------INGNEITFKSGKVE--HYDMIIEGVGTHPNSK--FIESSNIKLD 254 Query: 333 PRGRIPVNTRFQTKIPNIYAIGDV 356 +G IPVN +F+T +PNIYAIGD+ Sbjct: 255 RKGFIPVNDKFETNVPNIYAIGDI 278 >2BC1-A nrPDB Length = 490 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 82/352 (23%), Positives = 138/352 (39%), Gaps = 55/352 (15%) Query: 168 DGGTQVIDTKNILIATGSE--VTPFPGITIDEDTIVSSTGALSLKKVP------------ 213 DG V ++ ATGS+ + P G I E ++ +L+ V Sbjct: 130 DGKNHVETYDKLIFATGSQPILPPIKGAEIKEGSLEFEATLENLQFVKLYQNSADVIAKL 189 Query: 214 -----EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQ 268 +++ V+GAG IGVEL +QR G +V ++ + D +++ + +++ Sbjct: 190 ENKDIKRVAVVGAGYIGVELAEAFQRKGKEVVLIDVVDTCLAGYYDRDLTDLMAKNMEEH 249 Query: 269 GFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVIT-------CDVLLVCIGRRPFTKN 321 G + G T K E A GK E I D++++ +G RP N Sbjct: 250 GIQLAF-----GETVK---------EVAGNGKVEKIITDKNEYDVDMVILAVGFRP---N 292 Query: 322 LGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVA----------GPMLAHKAEDEGI 371 L I+L G VN R +T IP +YAIGD LA A GI Sbjct: 293 TTLGNGKIDLFRNGAFLVNKRQETSIPGVYAIGDCATIYDNATRDTNYIALASNAVRTGI 352 Query: 372 ICVEGMAGGAVH-IDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAK 430 + G + I + + G + E+ K G + V ++ Sbjct: 353 VAAHNACGTDLEGIGVQGSNGISIYGLHMVSTGLTLEKAKRLGFDAAVTEYTDNQKPEFI 412 Query: 431 TNADTDGMVKILGQKSTDRVLGAHILGPGAGEM-VNEAALALEYGASCEDIA 481 + + +KI+ K + R+LGA + M ++ +LA++ G + E +A Sbjct: 413 EHGNFPVTIKIVYDKDSRRILGAQMAAREDVSMGIHMFSLAIQEGVTIEKLA 464 >5ER0-A nrPDB Length = 518 Score = 57.0 bits (136), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 39/148 (26%), Positives = 68/148 (45%), Gaps = 10/148 (6%) Query: 211 KVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGF 270 K +++ VIGAG IG EL + G DVT ++ + V D + + ++ + G Sbjct: 195 KEAKRITVIGAGYIGAELAEAYSTTGHDVTLIDAMARVMPKYFDADFTDVIEQDYRDHGV 254 Query: 271 KFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIE 330 + L V T + G ++I+ D+ ++CIG RP N L + ++ Sbjct: 255 QLALGETVESFTDSATG---LTIKTDKNS----YETDLAILCIGFRP---NTDLLKGKVD 304 Query: 331 LDPRGRIPVNTRFQTKIPNIYAIGDVVA 358 + P G I + ++ P+I+A GD A Sbjct: 305 MAPNGAIITDDYMRSSNPDIFAAGDSAA 332 >1NHQ-A nrPDB Length = 447 Score = 56.2 bits (134), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 74/285 (25%), Positives = 121/285 (42%), Gaps = 54/285 (18%) Query: 110 GIEMSEVRLNLDKMME----QKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGK------ 159 G E E LNL E +K + L+ G+ L+ + KV VN +TG+ Sbjct: 12 GYEAVEELLNLHPDAEIQWYEKGDFISFLSSGM-QLYLEGKVKDVNSVRYMTGEKMESRG 70 Query: 160 ----------------NQVTATKADGGTQVIDTKNILIATGSEVTPF----PGITIDEDT 199 +QVT G + ++ + LI + V PF PG +D Sbjct: 71 VNVFSNTEITAIQPKEHQVTVKDLVSGEERVENYDKLIISPGAV-PFELDIPGKDLDNIY 129 Query: 200 IVS-STGALSLKKV---PE--KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGI 253 ++ A+ LK+ PE +VVIG+G IG+E + + G VT ++ L GV + Sbjct: 130 LMRGRQWAIKLKQKTVDPEVNNVVVIGSGYIGIEAAEAFAKAGKKVTVIDILDRPLGVYL 189 Query: 254 DMEISKNFQRILQKQGFKFKLNTKVTGAT---KKSDGKIDVSIEAASGGKAEVITCDVLL 310 D E + ++ T TG T + DG++ + + A D+++ Sbjct: 190 DKEFTDVLTEEMEANNI-----TIATGETVERYEGDGRVQKVVTDKNAYDA-----DLVV 239 Query: 311 VCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGD 355 V +G RP T L + +EL P G I + +T P+++A+GD Sbjct: 240 VAVGVRPNTAWL---KGTLELHPNGLIKTDEYMRTSEPDVFAVGD 281 >3NTA-A nrPDB Length = 574 Score = 55.8 bits (133), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 83/352 (23%), Positives = 143/352 (40%), Gaps = 49/352 (13%) Query: 168 DGGTQVIDTKNILIATGSE--VTPFPGI----------TIDEDTIVSSTGALSLKKVPEK 215 DG +L++ G+ V P PG+ D D I+ + + + V E Sbjct: 98 DGSEYQESYDTLLLSPGAAPIVPPIPGVDNPLTHSLRNIPDMDRILQT---IQMNNV-EH 153 Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 V+G G IG+E+ LG T +E V +D E++ + ++ QG +L Sbjct: 154 ATVVGGGFIGLEMMESLHHLGIKTTLLELADQVM-TPVDREMAGFAHQAIRDQGVDLRLG 212 Query: 276 TKVTGATKKSDGKIDVSIEAASGGKA---------------EVITCDVLLVCIGRRPFTK 320 T ++ + + + V+ +AA A E++ D+L++ IG RP T+ Sbjct: 213 TALSEVSYQV--QTHVASDAAGEDTAHQHIKGHLSLTLSNGELLETDLLIMAIGVRPETQ 270 Query: 321 NLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGP----------MLAHKAEDEG 370 + G+ + G I VN QT P IYA+GD V LA A +G Sbjct: 271 LA--RDAGLAIGELGGIKVNAMMQTSDPAIYAVGDAVEEQDFVTGQACLVPLAGPANRQG 328 Query: 371 IICVEGMAGGAVHIDYNCVPSVIYTHP-EVAWVGKSEEQLKEEGIEYKVGKFPFAANSRA 429 + + M G ++ V GK+E+QLK+ GI ++ A+++ Sbjct: 329 RMAADNMFGREERYQGTQGTAICKVFDLAVGATGKNEKQLKQAGIAFEKVYVHTASHASY 388 Query: 430 KTNADTDGMVKILGQKSTDRVLGAHILGP-GAGEMVNEAALALEYGASCEDI 480 A+ K+L + GA +G G + ++ A+A G + E + Sbjct: 389 YPGAEVVSF-KLLFDPVKGTIFGAQAVGKDGIDKRIDVMAVAQRAGMTVEQL 439 >3CGD-A nrPDB Length = 480 Score = 54.7 bits (130), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 72/290 (24%), Positives = 118/290 (40%), Gaps = 39/290 (13%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGV-------GIDMEISKNFQRILQ 266 E + +IG G IG+E+ + LG V +E H+G + I E K+ IL Sbjct: 187 EDVTIIGGGAIGLEMAETFVELGKKVRMIERNDHIGTIYDGDMAEYIYKEADKHHIEILT 246 Query: 267 KQGFK-FKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLE 325 + K FK N +V ++E G D++LV +G +P T LE Sbjct: 247 NENVKAFKGNERVE------------AVETDKG----TYKADLVLVSVGVKPNTD--FLE 288 Query: 326 ELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICV----EGMAGGA 381 I + +G I VN QT + ++YA GD + + D I +G G Sbjct: 289 GTNIRTNHKGAIEVNAYMQTNVQDVYAAGDCATHYHVIKEIHDHIPIGTTANKQGRLAGL 348 Query: 382 VHIDYNCVPS-------VIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNAD 434 +D + + + +A G +E++ K I YK K + NA Sbjct: 349 NMLDKRRAFKGTLGTGIIKFMNLTLARTGLNEKEAKGLHIPYKTVKVDSTNMAGYYPNAK 408 Query: 435 TDGMVKILGQKSTDRVLGAHILG-PGAGEMVNEAALALEYGASCEDIARV 483 +K+L + T ++LG ++G G + ++ A+AL S D+ V Sbjct: 409 P-LYLKLLYRSDTKQLLGGQVIGEEGVDKRIDVIAMALFNKMSIHDLEDV 457 Score = 28.9 bits (63), Expect = 5.1, Method: Compositional matrix adjust. Identities = 21/64 (32%), Positives = 31/64 (48%), Gaps = 6/64 (9%) Query: 19 RISHGLQGLSAVP-----LRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKN 73 R G+ L +P L+T ++ DVT+IG G G A +LG K IE+N Sbjct: 160 RDLQGVHLLKTIPDAERILKTLETNKVE-DVTIIGGGAIGLEMAETFVELGKKVRMIERN 218 Query: 74 ETLG 77 + +G Sbjct: 219 DHIG 222 >3OC4-A nrPDB Length = 452 Score = 51.6 bits (122), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 74/328 (22%), Positives = 132/328 (40%), Gaps = 66/328 (20%) Query: 205 GALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRI 264 A+ L + + + VIGAG IG+E ++ V E L ++ D E+ Q+ Sbjct: 139 AAVPLLENSQTVAVIGAGPIGMEAIDFLVKMKKTVHVFESLENLLPKYFDKEMVAEVQKS 198 Query: 265 LQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGL 324 L+KQ F V G + ++G + +E + + I+CD + + P L Sbjct: 199 LEKQAVIFHFEETVLGIEETANG---IVLETSE----QEISCDSGIFALNLHP---QLAY 248 Query: 325 EELGIELDPRGRIPVNTRFQTKIPNIYAIGD---VVAGPM-------LAHKAEDEGIICV 374 + I+ + I V+ QT +PN++AIGD V+ P+ L + A G++ Sbjct: 249 LDKKIQRNLDQTIAVDAYLQTSVPNVFAIGDCISVMNEPVAETFYAPLVNNAVRTGLVVA 308 Query: 375 EGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNA- 433 + TH ++G L+ G KVG + A+ +T Sbjct: 309 NNLEEK--------------TH---RFIGS----LRTMGT--KVGDYYLASTGLTETEGL 345 Query: 434 --------------------DTDGMVKILGQKSTDRVLGAHILGP-GAGEMVNEAALALE 472 T+ + K++ K T RVLGA + E +N AL+++ Sbjct: 346 FFPQTLASIIVRQPAPPLQHGTEILGKLIYDKVTQRVLGAQLCSKNNCLEKINTLALSIQ 405 Query: 473 YGASCEDIARVCHAH-PTLSEAFREANL 499 G + D+ + + + P+L+ + NL Sbjct: 406 TGQTLTDLLQKDYFYQPSLTNIYDITNL 433 >2A87-A nrPDB Length = 335 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 84/336 (25%), Positives = 129/336 (38%), Gaps = 51/336 (15%) Query: 27 LSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCI 86 ++A P+ A P+ DV VIGSGP GY AA+ AA+ + E + GG + + Sbjct: 1 MTAPPVHDRAHHPV-RDVIVIGSGPAGYTAALYAARAQLAPLVFEGT-SFGGALMTTTDV 58 Query: 87 PSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNK 146 + N GI E+ +D+M EQ AL G + Sbjct: 59 ENYPGFRN---------------GITGPEL---MDEMREQ------ALRFGAD--LRMED 92 Query: 147 VVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGA 206 V V+ +G + K+ VT ADG T + + + PG VSS Sbjct: 93 VESVSLHGPL--KSVVT---ADGQTHRARAVILAMGAAARYLQVPGEQELLGRGVSSCAT 147 Query: 207 LS-LKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRIL 265 + + VIG G +E + R VT V I ++ ++N +I Sbjct: 148 CDGFFFRDQDIAVIGGGDSAMEEATFLTRFARSVTLVHRRDEFRASKIMLDRARNNDKI- 206 Query: 266 QKQGFKFKLNTKVTGATKKSDGKIDVS---IEAASGGKAEVITCDVLLVCIGRRPFTKNL 322 +F N V DG V+ + + G + + V IG P + Sbjct: 207 -----RFLTNHTVVAV----DGDTTVTGLRVRDTNTGAETTLPVTGVFVAIGHEPRS--- 254 Query: 323 GLEELGIELDPRGRIPVNTR-FQTKIPNIYAIGDVV 357 GL I++DP G + V R T +P ++A GD+V Sbjct: 255 GLVREAIDVDPDGYVLVQGRTTSTSLPGVFAAGDLV 290 >2CDU-A nrPDB Length = 452 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 47/188 (25%), Positives = 79/188 (42%), Gaps = 19/188 (10%) Query: 179 ILIATGSE--VTPFPGITIDEDTIVSSTGALSLKKVPEK------MVVIGAGVIGVELGS 230 +++ TGS+ V P PGI D + KK+ E+ + +IG+G IG EL Sbjct: 109 LIMTTGSKPTVPPIPGI--DSSRVYLCKNYNDAKKLFEEAPKAKTITIIGSGYIGAELAE 166 Query: 231 VWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKID 290 + +V ++ V D E + + + G L +KV + D I Sbjct: 167 AYSNQNYNVNLIDGHERVLYKYFDKEFTDILAKDYEAHGVNLVLGSKVAAFEEVDDEIIT 226 Query: 291 VSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNI 350 +++ GK I D+ ++CIG RP N L + + + G I + + +I Sbjct: 227 KTLD----GKE--IKSDIAILCIGFRP---NTELLKGKVAMLDNGAIITDEYMHSSNRDI 277 Query: 351 YAIGDVVA 358 +A GD A Sbjct: 278 FAAGDSAA 285 >4EMJ-A nrPDB Length = 410 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 53/209 (25%), Positives = 98/209 (46%), Gaps = 17/209 (8%) Query: 161 QVTATKADGGTQVIDTKNILIATGSE--VTPFPGITIDEDTIVSSTGALSLKK----VPE 214 Q D GT + I+IATGS PG + + + G + + + Sbjct: 86 QTRTISLDDGT-TLSADAIVIATGSRARTMALPGSQLPGVVTLRTYGDVQVLRDSWTSAT 144 Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL 274 +++++G G+IG E+ + ++LG VT +E + + I + +L + G + +L Sbjct: 145 RLLIVGGGLIGCEVATTARKLGLSVTILEAGDELLVRVLGRRIGAWLRGLLTELGVQVEL 204 Query: 275 NTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPR 334 T V G + +G+++ + AS G++ V D L+C+G P + + G+ D R Sbjct: 205 GTGVVGFS--GEGQLEQVM--ASDGRSFV--ADSALICVGAEPADQL--ARQAGLACD-R 255 Query: 335 GRIPVNTRFQTKIPNIYAIGDVVAGPMLA 363 G I V+ T ++A+GDV + P+ A Sbjct: 256 GVI-VDHCGATLAKGVFAVGDVASWPLRA 283 >3FG2-P nrPDB Length = 404 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 43/164 (26%), Positives = 70/164 (42%), Gaps = 18/164 (10%) Query: 194 TIDEDTIVSSTGALSLKKVPEK--MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGV 251 T+DE ++ +++P+K +VVIGAG IG+E + + G +V VE V Sbjct: 128 TLDESEVLR-------QRMPDKKHVVVIGAGFIGLEFAATARAKGLEVDVVELAPRVMAR 180 Query: 252 GIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLV 311 + EIS F G + + T + D V + + CD+++V Sbjct: 181 VVTPEISSYFHDRHSGAGIRMHYGVRATEIAAEGDRVTGVVL-----SDGNTLPCDLVVV 235 Query: 312 CIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGD 355 +G P N+ + G I V+ + T P+I AIGD Sbjct: 236 GVGVIP---NVEIAAAAGLPTAAG-IIVDQQLLTSDPHISAIGD 275 >2V3B-A nrPDB Length = 384 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 39/142 (27%), Positives = 65/142 (45%), Gaps = 10/142 (7%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFK 273 +++++GAG+IG E + G + V V + +K Q L+ G +F Sbjct: 146 RRVLLLGAGLIGCEFANDLSSGGYQLDVVAPCEQVMPGLLHPAAAKAVQAGLEGLGVRFH 205 Query: 274 LNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDP 333 L V + KK+ ++ + EVI CD+++ +G RP T+ L + Sbjct: 206 LG-PVLASLKKAGEGLEAHLS-----DGEVIPCDLVVSAVGLRPRTELAFAAGLAVN--- 256 Query: 334 RGRIPVNTRFQTKIPNIYAIGD 355 RG I V+ +T NIYA+GD Sbjct: 257 RG-IVVDRSLRTSHANIYALGD 277 >2YVG-A nrPDB Length = 408 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 64/270 (23%), Positives = 109/270 (40%), Gaps = 51/270 (18%) Query: 97 YYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKI 156 Y KDF + G + ++RL+ + E V+ L G A F H Sbjct: 46 YDRPPLSKDFMAHG-DAEKIRLDCKRAPE-----VEWLLGVTAQSFDPQ--AH------- 90 Query: 157 TGKNQVTATKADGGTQVIDTKNILIATGSEVTPFP---GITIDEDTIVSSTGALSLK--- 210 T +DG T + +++ATG+ P G T+ T+ + A ++ Sbjct: 91 ------TVALSDGRT--LPYGTLVLATGAAPRALPTLQGATMPVHTLRTLEDARRIQAGL 142 Query: 211 KVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGF 270 + +++++G GVIG+EL + + G V+ VE + ++ R QG Sbjct: 143 RPQSRLLIVGGGVIGLELAATARTAGVHVSLVETQPRLMSRAAPATLADFVARYHAAQGV 202 Query: 271 KFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIG---RRPFTKNLGLE-E 326 + VTG+ +D + G + I D+++V IG + GL + Sbjct: 203 DLRFERSVTGS-------VDGVVLLDDGTR---IAADMVVVGIGVLANDALARAAGLACD 252 Query: 327 LGIELDPRGRIPVNTRFQTKIPNIYAIGDV 356 GI +D GR T P++YA+GDV Sbjct: 253 DGIFVDAYGR--------TTCPDVYALGDV 274 >3AB1-A nrPDB Length = 360 Score = 40.0 bits (92), Expect = 0.002, Method: Compositional matrix adjust. Identities = 78/336 (23%), Positives = 128/336 (38%), Gaps = 66/336 (19%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 102 D+T+IG GP G AA + IE LGG AL H Y +A Sbjct: 16 DLTIIGGGPTGIFAAFQCGMNNISCRIIESMPQLGGQL--------AALYPEKHIYDVAG 67 Query: 103 GKDFASRGIEMSEV------RLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKI 156 + + I++ E R N D ++ + T L G Sbjct: 68 FPEVPA--IDLVESLWAQAERYNPDVVLNETVTKYTKLDDG------------------- 106 Query: 157 TGKNQVTATKADGGTQVIDTKNILIATG---SEVTPFPGITIDEDTIVSSTGALSLKKVP 213 T+ + G V ++ +LIA G E P + + D + S+ ++K V Sbjct: 107 -----TFETRTNTG-NVYRSRAVLIAAGLGAFEPRKLPQLG-NIDHLTGSSVYYAVKSVE 159 Query: 214 E----KMVVIGAGVIGVELGSVWQRLGADVTAV----EFLGHVGGVGIDMEISKNFQRIL 265 + ++V++G G ++ + A VT V EF GH + + +R Sbjct: 160 DFKGKRVVIVGGGDSALDWTVGLIKNAASVTLVHRGHEFQGH-------GKTAHEVERAR 212 Query: 266 QKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLG-L 324 L T+V + ++S+G + +S G + D LL+ IG F NLG L Sbjct: 213 ANGTIDVYLETEV-ASIEESNGVLTRVHLRSSDGSKWTVEADRLLILIG---FKSNLGPL 268 Query: 325 EELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGP 360 +EL + V++ +T + +YA GD+ P Sbjct: 269 ARWDLELYENALV-VDSHMKTSVDGLYAAGDIAYYP 303 >1Q1R-A nrPDB Length = 431 Score = 39.7 bits (91), Expect = 0.003, Method: Compositional matrix adjust. Identities = 49/217 (22%), Positives = 92/217 (42%), Gaps = 24/217 (11%) Query: 155 KITGKNQVTATKAD------GGTQVIDTKNILIATGSEVTPFP------GITIDEDTIVS 202 ++ G QVTA D + +D +++ATG P P G + + + Sbjct: 76 QLLGGTQVTAINRDRQQVILSDGRALDYDRLVLATGGRPRPLPVASGAVGKANNFRYLRT 135 Query: 203 STGALSLKK---VPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISK 259 A +++ ++VVIG G IG+E+ + + VT ++ V +S Sbjct: 136 LEDAECIRRQLIADNRLVVIGGGYIGLEVAATAIKANMHVTLLDTAARVLERVTAPPVSA 195 Query: 260 NFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFT 319 ++ + ++ G + T+V G +D + ++ G + + D+++ IG P Sbjct: 196 FYEHLHREAGVDIRTGTQVCGFEMSTDQQKVTAVLCEDGTR---LPADLVIAGIGLIP-- 250 Query: 320 KNLGL-EELGIELDPRGRIPVNTRFQTKIPNIYAIGD 355 N L G+++D I +N QT P I A+GD Sbjct: 251 -NCELASAAGLQVD--NGIVINEHMQTSDPLIMAVGD 284 >4FX9-A nrPDB Length = 453 Score = 39.3 bits (90), Expect = 0.004, Method: Compositional matrix adjust. Identities = 62/282 (21%), Positives = 116/282 (41%), Gaps = 38/282 (13%) Query: 227 ELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSD 286 E+ + G +VT + V D E++ + L+K +N ++ T K + Sbjct: 165 EMAEAFAAQGKNVTMIVRGERVLRRSFDKEVTDILEEKLKKH-----VNLRLQEITMKIE 219 Query: 287 GKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGL-EELGIELDPRGRIPVNTRFQT 345 G+ V G+ + +++++ G +P N+ L ++LG+ + G I N + QT Sbjct: 220 GEERVEKVVTDAGEYK---AELVILATGIKP---NIELAKQLGVRIGETGAIWTNEKMQT 273 Query: 346 KIPNIYAIGDV-----------VAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVI- 393 + N+YA GDV V P LA G + +AG +H P V+ Sbjct: 274 SVENVYAAGDVAETRHVITGRRVWVP-LAPAGNKMGYVAGSNIAGKELHF-----PGVLG 327 Query: 394 -----YTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTD 448 + E+ G +E + +EG + + F A+ + +K + T+ Sbjct: 328 TAVTKFMDVEIGKTGLTEMEALKEGYDVRTA-FIKASTRPHYYPGGREIWLKGVVDNETN 386 Query: 449 RVLGAHILGPGAGEMVNEAALALEYGASCED--IARVCHAHP 488 R+LG ++G ++ AA L G + +D + +A P Sbjct: 387 RLLGVQVVGSDILPRIDTAAAMLMAGFTTKDAFFTDLAYAPP 428 >2Q7V-A nrPDB Length = 325 Score = 39.3 bits (90), Expect = 0.005, Method: Compositional matrix adjust. Identities = 74/325 (22%), Positives = 117/325 (36%), Gaps = 56/325 (17%) Query: 41 DADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHM 100 D DV +IG GP G AAI + T+ +EK G S+ + N + Sbjct: 8 DYDVVIIGGGPAGLTAAIYTGRAQLSTLILEKGMPGGQIAW------SEEVENFPGFPEP 61 Query: 101 AHGKDFASRGIEMSE---VRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGY-GKI 156 G + A R + +E ++ +D++ + A +H + V GY G+ Sbjct: 62 IAGMELAQRMHQQAEKFGAKVEMDEVQGVQHDAT-------SHPYP----FTVRGYNGEY 110 Query: 157 TGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKM 216 K + AT AD I ++ G T + G K K+ Sbjct: 111 RAKAVILATGADPRKLGIPGEDNFWGKGVS------------TCATCDGFFYKGK---KV 155 Query: 217 VVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGF-----K 271 VVIG G VE G + +VT I + ++ Q + F K Sbjct: 156 VVIGGGDAAVEEGMFLTKFADEVTV-----------IHRRDTLRANKVAQARAFANPKMK 204 Query: 272 FKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIEL 331 F +T V + +D V + G+ + D + + IG P N + + L Sbjct: 205 FIWDTAVE-EIQGADSVSGVKLRNLKTGEVSELATDGVFIFIGHVP---NTAFVKDTVSL 260 Query: 332 DPRGRIPVNTRFQTKIPNIYAIGDV 356 G + V T IP ++A GDV Sbjct: 261 RDDGYVDVRDEIYTNIPMLFAAGDV 285 >5JFC-L nrPDB Length = 474 Score = 37.0 bits (84), Expect = 0.020, Method: Compositional matrix adjust. Identities = 49/207 (23%), Positives = 82/207 (39%), Gaps = 27/207 (13%) Query: 179 ILIATGS---EVTPFPGITID----EDTIVSSTGALSLKKVPE---------KMVVIGAG 222 I I TG+ + P+PG+ ++ + ++ + K PE ++ VIG G Sbjct: 243 IFIGTGAGTPRIYPWPGVNLNGIYSANEFLTRINLMKAYKFPEYDTPIKVGKRVAVIGGG 302 Query: 223 VIGVELGSVWQRLGADV------TAVEFLGHVGGVGIDMEISKNFQRILQKQGF--KFKL 274 ++ RLGA+V T E + E F ++ + F Sbjct: 303 NTAMDAARSALRLGAEVWILYRRTRKEMTAREEEIKHAEEEGVKFMFLVTPKRFIGDENG 362 Query: 275 NTKVTGATKKSDGKIDVS--IEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELD 332 N K K G+ D S G+ ++ D ++ IG+ P K G+++D Sbjct: 363 NLKAIELEKMKLGEPDESGRRRPIPTGETFIMEFDTAIIAIGQTP-NKTFLETVPGLKVD 421 Query: 333 PRGRIPVNTRFQTKIPNIYAIGDVVAG 359 GRI V+ T IP ++A GD + G Sbjct: 422 EWGRIVVDENLMTSIPGVFAGGDAIRG 448 Score = 28.9 bits (63), Expect = 5.6, Method: Compositional matrix adjust. Identities = 26/92 (28%), Positives = 43/92 (46%), Gaps = 10/92 (10%) Query: 195 IDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGI- 253 ID++ ++ + K+ +K+ +IGAG G+ + ++G +VT E L GGV I Sbjct: 138 IDDELLLEEIKGI--KRNGKKVAIIGAGPAGLTCAADLAKMGYEVTIYEALHQPGGVLIY 195 Query: 254 -------DMEISKNFQRILQKQGFKFKLNTKV 278 EI K L++ G K + N V Sbjct: 196 GIPEFRLPKEIVKKELENLRRLGVKIETNVLV 227 >5MJK-A nrPDB Length = 327 Score = 36.6 bits (83), Expect = 0.025, Method: Compositional matrix adjust. Identities = 84/329 (25%), Positives = 124/329 (37%), Gaps = 72/329 (21%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 102 DV +IGSGP G AA+ A+ KT+ +E+ GG N A + N Y Sbjct: 26 DVVIIGSGPAGMTAAMYTARSEMKTLLLERG-VPGGQMNNT------AEIENYPGYETIM 78 Query: 103 GKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITG-KNQ 161 G + + ++M+E L G+ N YG +TG ++ Sbjct: 79 GPELS---MKMAEPLEGL----------------GVE-----------NAYGFVTGIEDH 108 Query: 162 VTATKADGGTQVIDTKNILIATGS--EVTPFPGITIDEDTIVSS----TGALSLKKVPEK 215 K TK+I+IATG+ PG VS GA ++ Sbjct: 109 GDYKKIITEDDEFITKSIIIATGANHRKLEIPGEEEYGARGVSYCAVCDGAFFRN---QE 165 Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKF-KL 274 ++VIG G VE R G VT + + Q I+Q++ FK K+ Sbjct: 166 ILVIGGGDSAVEEALYLTRFGQSVTIMHRRDKL-----------RAQEIIQQRAFKEEKI 214 Query: 275 N---TKVTGATKKSDGKID-VSIEAASGGKAEVITCDVLLVCIGRRP---FTKNLGLEEL 327 N V K D KI V + G+ + + +G P F +LG+ Sbjct: 215 NFIWDSVPMEIKGDDKKIQSVVYKNVKTGEVTEKAFGGIFIYVGLDPVAEFVSDLGI--- 271 Query: 328 GIELDPRGRIPVNTRFQTKIPNIYAIGDV 356 D G I + +T IP I+A+GDV Sbjct: 272 ---TDEAGWIITDDHMRTNIPGIFAVGDV 297 >3LXD-A nrPDB Length = 415 Score = 35.8 bits (81), Expect = 0.044, Method: Compositional matrix adjust. Identities = 43/154 (27%), Positives = 63/154 (40%), Gaps = 33/154 (21%) Query: 217 VVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL-- 274 VVIG G IG+E +V + G +VT +E L V +S+ +Q + G + Sbjct: 156 VVIGGGYIGLEAAAVLTKFGVNVTLLEALPRVLARVAGEALSEFYQAEHRAHGVDLRTGA 215 Query: 275 --------NTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEE 326 TKVTG + DG VI D+++V IG P L Sbjct: 216 AMDCIEGDGTKVTG-VRMQDGS--------------VIPADIVIVGIGIVPCVGAL---- 256 Query: 327 LGIELDPRG--RIPVNTRFQTKIPNIYAIGDVVA 358 I G + V+ +T + ++YAIGD A Sbjct: 257 --ISAGASGGNGVDVDEFCRTSLTDVYAIGDCAA 288 >4C3X-A nrPDB Length = 530 Score = 35.4 bits (80), Expect = 0.052, Method: Compositional matrix adjust. Identities = 19/49 (38%), Positives = 24/49 (48%) Query: 37 DQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGC 85 D + DV V+GSG G A AA G T+ +EK + GGT G Sbjct: 23 DWTSECDVLVVGSGGGALTGAYTAAAQGLTTIVLEKTDRFGGTSAYSGA 71 >5UTH-A nrPDB Length = 319 Score = 35.4 bits (80), Expect = 0.054, Method: Compositional matrix adjust. Identities = 18/40 (45%), Positives = 23/40 (57%), Gaps = 1/40 (2%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLN 82 DV +IGSGP GY AAI AA+ K + E + GG + Sbjct: 17 DVIIIGSGPAGYTAAIYAARAQLKPLVFEGTQ-FGGALMT 55 >4ZN0-A nrPDB Length = 311 Score = 35.0 bits (79), Expect = 0.069, Method: Compositional matrix adjust. Identities = 15/35 (42%), Positives = 21/35 (60%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLG 77 D+ +IG GP G A I A + G T+ +E+NE G Sbjct: 9 DLIIIGGGPAGLTAGIYAVRYGLDTLILERNEISG 43 >4Y4N-A nrPDB Length = 286 Score = 34.7 bits (78), Expect = 0.091, Method: Compositional matrix adjust. Identities = 15/34 (44%), Positives = 22/34 (64%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKN 73 ID DV ++G GP G AA A+ G+K V +E++ Sbjct: 51 IDVDVAIVGGGPSGLTAARYIAKEGYKVVVLERH 84 >5YGQ-A nrPDB Length = 342 Score = 34.7 bits (78), Expect = 0.099, Method: Compositional matrix adjust. Identities = 29/88 (32%), Positives = 43/88 (48%), Gaps = 17/88 (19%) Query: 275 NTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLG-LEELGIELDP 333 N ++TGAT K + I+ CD +L G T LG + G++L+ Sbjct: 222 NGQLTGATVKLNDNTTSQIK-----------CDAMLPFFG---LTMKLGPVANWGLDLE- 266 Query: 334 RGRIPVNT-RFQTKIPNIYAIGDVVAGP 360 IPV+T F+T +P I+AIGD+ P Sbjct: 267 NNLIPVDTGTFETNVPGIFAIGDINTYP 294 Score = 28.5 bits (62), Expect = 7.3, Method: Compositional matrix adjust. Identities = 13/41 (31%), Positives = 21/41 (51%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTC 80 I DV ++G+GP G A + L K ++ + +GG C Sbjct: 5 IKTDVLIVGAGPCGLFAVFELGLLDVKAHLVDILDKVGGQC 45 >4Y4M-A nrPDB Length = 290 Score = 34.3 bits (77), Expect = 0.12, Method: Compositional matrix adjust. Identities = 14/34 (41%), Positives = 23/34 (67%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKN 73 ++ADV ++G+GP G A A+ GFK V +E++ Sbjct: 58 VEADVVIVGAGPSGLTCARYLAKEGFKVVVLERH 91 >4JNQ-A nrPDB Length = 345 Score = 34.3 bits (77), Expect = 0.15, Method: Compositional matrix adjust. Identities = 18/29 (62%), Positives = 19/29 (65%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCI 70 A V VIGSGP GY AAI AA+ K V I Sbjct: 27 APVIVIGSGPAGYTAAIYAARAMLKPVVI 55 >3RHA-A nrPDB Length = 482 Score = 33.9 bits (76), Expect = 0.16, Method: Compositional matrix adjust. Identities = 14/41 (34%), Positives = 23/41 (56%) Query: 38 QPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 Q +D DV ++G+GP G AA + + G +E + +GG Sbjct: 4 QNLDRDVVIVGAGPSGLTAARELKKAGLSVAVLEARDRVGG 44 >5BR7-A nrPDB Length = 393 Score = 33.5 bits (75), Expect = 0.20, Method: Compositional matrix adjust. Identities = 19/43 (44%), Positives = 25/43 (58%), Gaps = 1/43 (2%) Query: 41 DADVTVIGSGPGGYVAAIKAA-QLGFKTVCIEKNETLGGTCLN 82 D D+ V+GSG G A +AA QLG K + +EK LGG + Sbjct: 3 DFDLIVVGSGLFGLTVAERAASQLGKKVLIVEKRSHLGGNAYS 45 >4MO2-B nrPDB Length = 368 Score = 33.5 bits (75), Expect = 0.21, Method: Compositional matrix adjust. Identities = 13/38 (34%), Positives = 23/38 (60%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTC 80 D ++GSG G + A +A + G+ + +E+ E +GG C Sbjct: 3 DYLIVGSGLFGSIFAYEATEKGYTCLVVEQREHIGGNC 40 >5NMX-A nrPDB Length = 425 Score = 33.5 bits (75), Expect = 0.22, Method: Compositional matrix adjust. Identities = 15/36 (41%), Positives = 21/36 (58%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGT 79 V V+G+GP G AA Q GF+ + E+ +GGT Sbjct: 4 VAVLGAGPSGLTAARYLKQAGFEVMVFERYHHVGGT 39 >2GMH-A nrPDB Length = 584 Score = 33.5 bits (75), Expect = 0.25, Method: Compositional matrix adjust. Identities = 17/57 (29%), Positives = 28/57 (49%), Gaps = 6/57 (10%) Query: 41 DADVTVIGSGPGGYVAAIKAAQLG------FKTVCIEKNETLGGTCLNVGCIPSKAL 91 +ADV ++G+GP G AA + QL + +EK +G L+ C+ +A Sbjct: 35 EADVVIVGAGPAGLSAATRLKQLAAQHEKDLRVCLVEKAAHIGAHTLSGACLDPRAF 91 >5VJ7-A nrPDB Length = 476 Score = 33.1 bits (74), Expect = 0.28, Method: Compositional matrix adjust. Identities = 22/63 (34%), Positives = 33/63 (52%), Gaps = 3/63 (4%) Query: 299 GKAEVIT--CDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDV 356 G E IT D +++ IG+ P K L +++D GRI V+ T IP ++A GD Sbjct: 388 GTGEYITVEADTVIIAIGQTP-NKVLWRATPELKVDEWGRIVVDENLMTSIPGVFAGGDA 446 Query: 357 VAG 359 + G Sbjct: 447 IRG 449 >5HCE-A nrPDB Length = 998 Score = 33.1 bits (74), Expect = 0.32, Method: Compositional matrix adjust. Identities = 29/119 (24%), Positives = 51/119 (42%), Gaps = 21/119 (17%) Query: 289 IDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRG------------- 335 I+ S+E G + V T V+ + R ++ G+ LDPRG Sbjct: 232 INFSLETWFGKEILVKTLRVVPEGVKRESYS--------GVTLDPRGIYGTISRRKEFPY 283 Query: 336 RIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIY 394 RIP++ +T+I I ++ ++ G +L+ EGI + + G+ + V V Y Sbjct: 284 RIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFY 342 >5XHU-A nrPDB Length = 329 Score = 32.3 bits (72), Expect = 0.46, Method: Compositional matrix adjust. Identities = 73/332 (21%), Positives = 123/332 (37%), Gaps = 72/332 (21%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTC---------LNVGCIPSKALLN 93 DVT+IG GP G A KT IE LGG ++G IP A Sbjct: 4 DVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGGKVSLFFPEKIIRDIGGIPGIA--- 60 Query: 94 NSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGY 153 GK + E + + D ++ Q+ T + L G Sbjct: 61 ---------GKQLIEQLKEQAAT-FDPDIVLNQRVTGFERLDDG---------------- 94 Query: 154 GKITGKNQVTATKADGGTQVIDTKNILIATGS---EVTPFPGITIDEDTIVSS-----TG 205 + T ++G T+ +++A G EV F ED + G Sbjct: 95 -------TIVLTGSEGKKHY--TRTVILACGMGTLEVNEFD----SEDAARYAGKNLHYG 141 Query: 206 ALSLKKVPEKMVVI-GAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRI 264 L K VVI G G V+ + + + A VT V GG ++ ++K Sbjct: 142 VEKLDAFKGKRVVISGGGDTAVDWANELEPIAASVTVVHRREEFGG--MESSVTK----- 194 Query: 265 LQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLG- 323 +++ + ++ +G V++ G+ + I D L++ G F +LG Sbjct: 195 MKQSSVRVLTPYRLEQLNGDEEGIKSVTVCHTESGQRKDIEIDELIINHG---FKIDLGP 251 Query: 324 LEELGIELDPRGRIPVNTRFQTKIPNIYAIGD 355 + E G+E++ GR+ + +T +P ++ GD Sbjct: 252 MMEWGLEIE-EGRVKADRHMRTNLPGVFVAGD 282 >2ZBW-A nrPDB Length = 335 Score = 32.3 bits (72), Expect = 0.52, Method: Compositional matrix adjust. Identities = 20/58 (34%), Positives = 31/58 (53%), Gaps = 5/58 (8%) Query: 304 ITCDVLLVCIGRRPFTKNLG-LEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGP 360 + D +L+ G + LG L G+ L+ + +I V+T T IP +YA GD+V P Sbjct: 239 LEVDAVLILAG---YITKLGPLANWGLALE-KNKIKVDTTMATSIPGVYACGDIVTYP 292 >3F8P-A nrPDB Length = 323 Score = 32.0 bits (71), Expect = 0.60, Method: Compositional matrix adjust. Identities = 22/61 (36%), Positives = 34/61 (55%), Gaps = 4/61 (6%) Query: 27 LSAVPLRTYADQPIDA-DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGC 85 +S +P RT + +P + DV ++G GP Y AA+ +A+ KT+ I ET GG G Sbjct: 1 MSLLP-RTTSVKPGEKFDVIIVGLGPAAYGAALYSARYMLKTLVI--GETPGGQLTEAGI 57 Query: 86 I 86 + Sbjct: 58 V 58 Score = 29.3 bits (64), Expect = 4.4, Method: Compositional matrix adjust. Identities = 25/94 (26%), Positives = 43/94 (45%), Gaps = 3/94 (3%) Query: 262 QRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKN 321 + + +K +F LN+ V K V +E G+ + + + + + IG P T Sbjct: 197 ETVKKKPNVEFVLNS-VVKEIKGDKVVKQVVVENLKTGEIKELNVNGVFIEIGFDPPTDF 255 Query: 322 LGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGD 355 + GIE D G I V+ +T +P ++A GD Sbjct: 256 A--KSNGIETDTNGYIKVDEWMRTSVPGVFAAGD 287 >5U63-A nrPDB Length = 321 Score = 32.0 bits (71), Expect = 0.61, Method: Compositional matrix adjust. Identities = 14/29 (48%), Positives = 19/29 (65%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCI 70 A + ++GSGP GY AAI AA+ K V + Sbjct: 10 AKLLILGSGPAGYTAAIYAARANLKPVLV 38 >3K30-A nrPDB Length = 690 Score = 32.0 bits (71), Expect = 0.62, Method: Compositional matrix adjust. Identities = 19/61 (31%), Positives = 24/61 (39%) Query: 41 DADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHM 100 DA V V+G+GP G AA G+ V E LGG +P + Y Sbjct: 391 DARVLVVGAGPSGLEAARALGVRGYDVVLAEAGRDLGGRVTQESALPGLSAWGRVKEYRE 450 Query: 101 A 101 A Sbjct: 451 A 451 Score = 32.0 bits (71), Expect = 0.71, Method: Compositional matrix adjust. Identities = 23/85 (27%), Positives = 43/85 (50%), Gaps = 8/85 (9%) Query: 146 KVVHVNG--YGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSS 203 +V H NG Y + + + KA+GG + T+ + I S++ PF + I +D + Sbjct: 31 QVPHCNGMGYRDPSAQASMRKIKAEGGWSAVCTEQVEIHATSDIAPFIELRIWDDQDLP- 89 Query: 204 TGALSLKKVPEKMVVIGAGVIGVEL 228 +LK++ + + G G+ G+EL Sbjct: 90 ----ALKRIADA-IHEGGGLAGIEL 109 >5UWY-A nrPDB Length = 308 Score = 32.0 bits (71), Expect = 0.64, Method: Compositional matrix adjust. Identities = 76/323 (23%), Positives = 122/323 (37%), Gaps = 60/323 (18%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 102 D +IGSGP G AA+ AA+ IE+ GG N I N Y H++ Sbjct: 6 DTLIIGSGPAGMTAALYAARSNLSVAIIEQGAP-GGQMNNTFDIE-----NYPGYDHIS- 58 Query: 103 GKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQV 162 G + A + E E + N++ + GI K+ + Y + ++ Sbjct: 59 GPELAMKMYEPLE-KFNVENIY------------GIVQ-----KIENFGDYKCVLTEDAS 100 Query: 163 TATKADGGTQVIDTKNILIATGSE--VTPFPGITIDEDTIVSSTGALSLKKVPEK-MVVI 219 + K ++IATG++ V PG VS ++ ++V+ Sbjct: 101 -----------YEAKTVIIATGAKYRVLGVPGEEYYTSRGVSYCAVCDGAFFRDQDLLVV 149 Query: 220 GAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGF-----KFKL 274 G G VE + VT V + Q+ILQ + F F Sbjct: 150 GGGDSAVEEAIYLTQFAKKVTVVHRRDQLRA-----------QKILQDRAFANDKVDFIW 198 Query: 275 NTKVTGATKKSDGKI-DVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDP 333 ++ V + +D K+ +V IE G+ + + +G P T + E+ D Sbjct: 199 DS-VVKEIQGNDIKVSNVLIENVKTGQVTDHAFGGVFIYVGMNPVTGMVKDLEI---TDS 254 Query: 334 RGRIPVNTRFQTKIPNIYAIGDV 356 G I + +T IP I+AIGDV Sbjct: 255 EGWIITDDHMRTSIPGIFAIGDV 277 >3NIX-A nrPDB Length = 421 Score = 32.0 bits (71), Expect = 0.71, Method: Compositional matrix adjust. Identities = 16/32 (50%), Positives = 20/32 (62%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNE 74 DV VIG+GP G VAA + GFK +EK + Sbjct: 7 DVLVIGAGPAGTVAASLVNKSGFKVKIVEKQK 38 >1PS9-A nrPDB Length = 671 Score = 31.6 bits (70), Expect = 0.83, Method: Compositional matrix adjust. Identities = 22/79 (27%), Positives = 35/79 (44%), Gaps = 8/79 (10%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 102 ++ V+G+GP G AI AA G + + + +GG IP K + Y+ Sbjct: 375 NLAVVGAGPAGLAFAINAAARGHQVTLFDAHSEIGGQFNIAKQIPGKEEFYETLRYY--- 431 Query: 103 GKDFASRGIEMSEVRLNLD 121 R IE++ V L L+ Sbjct: 432 -----RRMIEVTGVTLKLN 445 >6BWT-A nrPDB Length = 319 Score = 31.6 bits (70), Expect = 0.95, Method: Compositional matrix adjust. Identities = 14/27 (51%), Positives = 18/27 (66%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCI 70 + ++GSGP GY AAI AA+ K V I Sbjct: 10 LIILGSGPAGYTAAIYAARANLKPVII 36 >4WEQ-A nrPDB Length = 341 Score = 31.2 bits (69), Expect = 1.2, Method: Compositional matrix adjust. Identities = 38/134 (28%), Positives = 55/134 (41%), Gaps = 35/134 (26%) Query: 1 MQSWSRVYCSLAKRGH--FNRIS--HGLQGLSAVPLRTYADQPIDADVTV--IGSGPGGY 54 M W + C L R H + ++ H + LS QP ADVTV +G G G Sbjct: 124 MSEWVMMQCLLHLRQHRAYEALAKKHEWRDLS---------QPEAADVTVGIMGMGVLGQ 174 Query: 55 VAAIKAAQLGFKTV-------CIEKNET---------LGGTCLNVGCIP----SKALLNN 94 AA K A +GFK + IE ET LG T VG +P ++ + N Sbjct: 175 DAARKLAAMGFKVIGWSRSKRVIEGVETYDAAGLDAFLGRTDFLVGLLPLTPDTRGIFNA 234 Query: 95 SHYYHMAHGKDFAS 108 + + ++ F + Sbjct: 235 ALFAKLSRNGPFGA 248 >3UKH-A nrPDB Length = 519 Score = 30.8 bits (68), Expect = 1.3, Method: Compositional matrix adjust. Identities = 18/40 (45%), Positives = 24/40 (60%), Gaps = 1/40 (2%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQL-GFKTVCIEKNETLGG 78 I DV VIG+GP G AA + Q+ G + ++ NET GG Sbjct: 5 ISVDVLVIGAGPTGLGAAKRLNQIDGPSWMIVDSNETPGG 44 >5L3D-A nrPDB Length = 852 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 15/36 (41%), Positives = 21/36 (58%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGG 250 K+++IG+GV G+ Q G DVT +E VGG Sbjct: 280 KVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGG 315 >6GAR-A nrPDB Length = 349 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 18/51 (35%), Positives = 25/51 (49%), Gaps = 3/51 (5%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLN 93 DVTVIG GP G +A + +T IE + LGG + P K + + Sbjct: 8 DVTVIGGGPAGLYSAFYSGLREMRTKIIEFHPHLGG---KIHVYPEKMIWD 55 >3ABT-A nrPDB Length = 662 Score = 30.4 bits (67), Expect = 1.7, Method: Compositional matrix adjust. Identities = 15/36 (41%), Positives = 21/36 (58%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGG 250 K+++IG+GV G+ Q G DVT +E VGG Sbjct: 109 KVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGG 144 >5W4C-A nrPDB Length = 371 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 17/42 (40%), Positives = 24/42 (57%), Gaps = 1/42 (2%) Query: 31 PLRT-YADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIE 71 P RT + + + V +IGSGPGG+ AAI A+ + V E Sbjct: 19 PKRTGEVSKKMHSKVVIIGSGPGGHTAAIYLARANLEPVLYE 60 >6GAS-A nrPDB Length = 331 Score = 30.0 bits (66), Expect = 2.3, Method: Compositional matrix adjust. Identities = 15/40 (37%), Positives = 26/40 (65%), Gaps = 2/40 (5%) Query: 318 FTKNLG-LEELGIELDPRGRIPVNTRFQTKIPNIYAIGDV 356 F +LG ++ G+++ + I VN++ +T IP IYA GD+ Sbjct: 250 FVSSLGPIKNWGLDIQ-KNSILVNSKMETNIPGIYAAGDI 288 >1I8T-A nrPDB Length = 367 Score = 30.0 bits (66), Expect = 2.4, Method: Compositional matrix adjust. Identities = 15/43 (34%), Positives = 21/43 (48%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGC 85 D ++GSG G V A + +L K + IEK +GG C Sbjct: 3 DYIIVGSGLFGAVCANELKKLNKKVLVIEKRNHIGGNAYTEDC 45 >1F6M-A nrPDB Length = 320 Score = 30.0 bits (66), Expect = 2.7, Method: Compositional matrix adjust. Identities = 12/25 (48%), Positives = 17/25 (68%) Query: 46 VIGSGPGGYVAAIKAAQLGFKTVCI 70 ++GSGP GY AA+ AA+ + V I Sbjct: 10 ILGSGPAGYTAAVYAARANLQPVLI 34 >3COX-A nrPDB Length = 507 Score = 29.6 bits (65), Expect = 3.1, Method: Compositional matrix adjust. Identities = 19/41 (46%), Positives = 22/41 (53%), Gaps = 1/41 (2%) Query: 31 PLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIE 71 P RT AD VIGSG GG VAA++ Q G T +E Sbjct: 2 PSRTLADGD-RVPALVIGSGYGGAVAALRLTQAGIPTQIVE 41 >3UP5-A nrPDB Length = 545 Score = 29.6 bits (65), Expect = 3.2, Method: Compositional matrix adjust. Identities = 30/96 (31%), Positives = 40/96 (41%), Gaps = 10/96 (10%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 102 D VIG+G G A Q G K + IE E +GGT P L S+ Y Sbjct: 11 DAVVIGAGVTGIYQAFLINQAGMKVLGIEAGEDVGGTWY-WNRYPGCRLDTESYAYGY-- 67 Query: 103 GKDFASRGI----EMSEVRLNLDKMMEQKSTAVKAL 134 FA +GI E SE + +M+ + A A+ Sbjct: 68 ---FALKGIIPEWEWSENFASQPEMLRYVNRAADAM 100 >4Z2R-A nrPDB Length = 592 Score = 29.6 bits (65), Expect = 3.6, Method: Compositional matrix adjust. Identities = 11/32 (34%), Positives = 21/32 (65%) Query: 41 DADVTVIGSGPGGYVAAIKAAQLGFKTVCIEK 72 + DV ++G+GP G ++A A LG +++ I + Sbjct: 12 ETDVLIVGAGPAGAMSATLLASLGIRSLMINR 43 >1NAA-A nrPDB Length = 541 Score = 29.3 bits (64), Expect = 3.7, Method: Compositional matrix adjust. Identities = 11/30 (36%), Positives = 21/30 (70%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEK 72 D ++G+GPGG +AA + ++ G K + +E+ Sbjct: 4 DYIIVGAGPGGIIAADRLSEAGKKVLLLER 33 >1XHC-A nrPDB Length = 367 Score = 29.3 bits (64), Expect = 3.7, Method: Compositional matrix adjust. Identities = 30/105 (28%), Positives = 50/105 (47%), Gaps = 15/105 (14%) Query: 251 VGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLL 310 +G+D E+S + +L++ G KF LN+++ A ++ + SG I V + Sbjct: 179 LGLDEELSNMIKDMLEETGVKFFLNSELLEANEE-------GVLTNSG----FIEGKVKI 227 Query: 311 VCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGD 355 IG P N+ L RG I ++ F+T ++YAIGD Sbjct: 228 CAIGIVP---NVDLARRSGIHTGRG-ILIDDNFRTSAKDVYAIGD 268 >2VVL-G nrPDB Length = 495 Score = 29.3 bits (64), Expect = 4.1, Method: Compositional matrix adjust. Identities = 27/93 (29%), Positives = 38/93 (40%), Gaps = 16/93 (17%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCL--NVGCIP-----SKALLNNS 95 DV VIG G G A GFKT+ +E + +GG N+ P + + S Sbjct: 41 DVIVIGGGYCGLTATRDLTVAGFKTLLLEARDRIGGRSWSSNIDGYPYEMGGTWVHWHQS 100 Query: 96 HYY--------HMAHGKDFA-SRGIEMSEVRLN 119 H + H A F SRG+ ++R N Sbjct: 101 HVWREITRYKMHNALSPSFNFSRGVNHFQLRTN 133 >5USX-A nrPDB Length = 319 Score = 29.3 bits (64), Expect = 4.4, Method: Compositional matrix adjust. Identities = 12/25 (48%), Positives = 16/25 (64%) Query: 46 VIGSGPGGYVAAIKAAQLGFKTVCI 70 ++GSGP GY AA+ AA+ V I Sbjct: 11 ILGSGPAGYTAAVYAARANLNPVLI 35 >4TXK-A nrPDB Length = 615 Score = 28.9 bits (63), Expect = 5.1, Method: Compositional matrix adjust. Identities = 17/50 (34%), Positives = 25/50 (50%), Gaps = 8/50 (16%) Query: 32 LRTYADQPI--------DADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKN 73 L A QP+ + V+G+GP G AA++ A LG + V +EK Sbjct: 67 LDKRASQPVYQQGQACTNTKCLVVGAGPCGLRAAVELALLGARVVLVEKR 116 >5AYV-A nrPDB Length = 309 Score = 28.9 bits (63), Expect = 5.3, Method: Compositional matrix adjust. Identities = 32/123 (26%), Positives = 52/123 (42%), Gaps = 15/123 (12%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL 274 ++ V+GAG IG G++ R G DVT + V I+KN + + F K Sbjct: 2 RIYVLGAGSIGSLFGALLARAGNDVTLIGRREQVDA------INKNGLHVFGAEEFTVKP 55 Query: 275 NTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFT----KNLGLEELGIE 330 + + D I +++++ S A + CIGR + LG EEL ++ Sbjct: 56 KATIYAPEEPPDLLI-LAVKSYSTKTA----LECARQCIGRNTWVLSIQNGLGNEELALK 110 Query: 331 LDP 333 P Sbjct: 111 YTP 113 >2BRY-A nrPDB Length = 497 Score = 28.9 bits (63), Expect = 5.3, Method: Compositional matrix adjust. Identities = 16/46 (34%), Positives = 24/46 (52%), Gaps = 8/46 (17%) Query: 36 ADQPI--------DADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKN 73 A QP+ + V+G+GP G AA++ A LG + V +EK Sbjct: 79 ASQPVYQQGQACTNTKCLVVGAGPCGLRAAVELALLGARVVLVEKR 124 >6C6P-A nrPDB Length = 458 Score = 28.9 bits (63), Expect = 5.8, Method: Compositional matrix adjust. Identities = 14/31 (45%), Positives = 21/31 (67%), Gaps = 1/31 (3%) Query: 213 PEKMVVIGAGVIGVELGSVWQRLGADVTAVE 243 PE ++++GAGV+G L +V R G VT +E Sbjct: 8 PE-VIIVGAGVLGSALAAVLSRDGRKVTVIE 37 >1VL1-A nrPDB Length = 232 Score = 28.9 bits (63), Expect = 6.1, Method: Compositional matrix adjust. Identities = 20/82 (24%), Positives = 39/82 (47%), Gaps = 3/82 (3%) Query: 32 LRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKAL 91 +R+ DQ D+ ++G GP G+VA+I + G K + + G + + +AL Sbjct: 131 IRSATDQ---FDLAILGMGPDGHVASIFDLETGNKDNLVTFTDPSGDPKVPRVTLTFRAL 187 Query: 92 LNNSHYYHMAHGKDFASRGIEM 113 + + + GK+ +R E+ Sbjct: 188 NTSLYVLFLIRGKEKINRLTEI 209 >5GVS-A nrPDB Length = 231 Score = 28.5 bits (62), Expect = 7.4, Method: Compositional matrix adjust. Identities = 19/73 (26%), Positives = 31/73 (42%), Gaps = 3/73 (4%) Query: 254 DMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCI 313 +M+ R L+K+G ++ G G+ + I GK V T V++ C+ Sbjct: 17 EMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCL 76 Query: 314 ---GRRPFTKNLG 323 R PF+K G Sbjct: 77 EQEKRLPFSKREG 89 >4CBQ-A nrPDB Length = 314 Score = 28.5 bits (62), Expect = 7.7, Method: Compositional matrix adjust. Identities = 72/324 (22%), Positives = 123/324 (37%), Gaps = 54/324 (16%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 102 DV +IGSGP + AAI + K V E + G G + + ++ N + Sbjct: 6 DVVIIGSGPAAHTAAIYLGRSSLKPVMYEG--FMAGGVAAGGQLTTTTIIENFPGF---- 59 Query: 103 GKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQV 162 GI+ +E+ +N+ E+ T + +T I H + Q Sbjct: 60 -----PNGIDGNELMMNMRTQSEKYGTTI--ITETIDH---------------VDFSTQP 97 Query: 163 TATKADGGTQVIDTKNILIATGSEVTPF--PGITIDEDTIVS---STGALSLKKVP---- 213 + G +V+ TK+++IATG+ PG ED S A+ VP Sbjct: 98 FKLFTEEGKEVL-TKSVIIATGATAKRMHVPG----EDKYWQNGVSACAICDGAVPIFRN 152 Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQ-RILQKQGFKF 272 + ++V+G G +E + G+ V + SK Q R+L + Sbjct: 153 KVLMVVGGGDAAMEEALHLTKYGSKVIILHRRD-------AFRASKTMQERVLNHPKIEV 205 Query: 273 KLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELD 332 N+++ D I G+ +V+ L IG P +K LG + ++ Sbjct: 206 IWNSELVELEGDGDLLNGAKIHNLVSGEYKVVPVAGLFYAIGHSPNSKFLGGQ---VKTA 262 Query: 333 PRGRIPVNTRFQTKIPNIYAIGDV 356 G I + +T + ++A GDV Sbjct: 263 DDGYI-LTEGPKTSVDGVFACGDV 285 >5H1Y-A nrPDB Length = 281 Score = 28.5 bits (62), Expect = 8.1, Method: Compositional matrix adjust. Identities = 19/73 (26%), Positives = 31/73 (42%), Gaps = 3/73 (4%) Query: 254 DMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCI 313 +M+ R L+K+G ++ G G+ + I GK V T V++ C+ Sbjct: 56 EMKFPAAILRGLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCL 115 Query: 314 ---GRRPFTKNLG 323 R PF+K G Sbjct: 116 EQEKRLPFSKREG 128 >5MYJ-BM nrPDB Length = 148 Score = 28.1 bits (61), Expect = 9.3, Method: Compositional matrix adjust. Identities = 15/39 (38%), Positives = 24/39 (61%), Gaps = 6/39 (15%) Query: 439 VKILGQKSTDRVLGAHILGPG------AGEMVNEAALAL 471 +K+ G+K+TD+V +H L PG AGE+ + A+ L Sbjct: 64 IKLTGKKATDKVYYSHSLHPGGLKSVTAGELREKNAVRL 102 >4YRY-B nrPDB Length = 468 Score = 28.1 bits (61), Expect = 9.9, Method: Compositional matrix adjust. Identities = 14/38 (36%), Positives = 19/38 (50%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCL 81 V V+GSGP G AA A++G+ E GG + Sbjct: 143 VAVVGSGPAGLTAAADLAKMGYHVDIFEAFHKPGGVLV 180 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 5J5Z-A nrPDB 633 0.0 3URH-A nrPDB 532 e-151 1DXL-A nrPDB 527 e-150 5U8W-A nrPDB 526 e-150 1V59-A nrPDB 522 e-148 5TR3-A nrPDB 520 e-148 3LAD-A nrPDB 514 e-146 6BZ0-A nrPDB 500 e-142 2YQU-A nrPDB 496 e-140 6N7F-A nrPDB 495 e-140 5VDN-A nrPDB 492 e-139 1GEU-A nrPDB 492 e-139 2QAE-A nrPDB 491 e-139 1EBD-A nrPDB 490 e-139 1ZDL-A nrPDB 490 e-139 2X8H-A nrPDB 485 e-137 6AON-A nrPDB 481 e-136 4LA1-A nrPDB 478 e-135 4JDR-A nrPDB 475 e-134 2R9Z-A nrPDB 475 e-134 6B4O-A nrPDB 470 e-133 5U1O-A nrPDB 470 e-133 4KPR-E nrPDB 469 e-132 2AAQ-A nrPDB 469 e-132 2CFY-A nrPDB 467 e-132 2EQ6-A nrPDB 467 e-132 6DU7-A nrPDB 464 e-131 5V36-A nrPDB 461 e-130 2NVK-X nrPDB 460 e-130 2WOV-A nrPDB 459 e-129 2HQM-A nrPDB 458 e-129 2YAU-A nrPDB 453 e-127 1FEC-A nrPDB 452 e-127 4NEW-A nrPDB 451 e-127 5W1J-A nrPDB 450 e-127 4B1B-A nrPDB 448 e-126 6CMZ-A nrPDB 446 e-126 1LVL-A nrPDB 440 e-124 3O0H-A nrPDB 440 e-124 5X1Y-B nrPDB 425 e-119 3II4-A nrPDB 425 e-119 4DNA-A nrPDB 420 e-118 1ONF-A nrPDB 400 e-111 1OJT-A nrPDB 388 e-108 5U25-A nrPDB 385 e-107 4YWO-A nrPDB 384 e-107 1ZK7-A nrPDB 375 e-104 1XDI-A nrPDB 332 2e-91 3IC9-A nrPDB 317 8e-87 3L8K-A nrPDB 316 1e-86 3Q6J-A nrPDB 315 3e-86 2BC1-A nrPDB 220 8e-58 3ICS-A nrPDB 214 8e-56 3NTA-A nrPDB 208 6e-54 3CGD-A nrPDB 200 1e-51 5ER0-A nrPDB 191 8e-49 1NHQ-A nrPDB 190 1e-48 3OC4-A nrPDB 188 3e-48 2A87-A nrPDB 174 6e-44 4GCM-A nrPDB 172 3e-43 2CDU-A nrPDB 172 3e-43 3IWA-A nrPDB 172 4e-43 1YQZ-A nrPDB 159 3e-39 5JCN-A nrPDB 151 6e-37 2V3B-A nrPDB 138 4e-33 2YVG-A nrPDB 133 1e-31 3FG2-P nrPDB 133 2e-31 4EMJ-A nrPDB 119 3e-27 Sequences not found previously or not previously below threshold: 5UTH-A nrPDB 139 3e-33 5MJK-A nrPDB 136 3e-32 5UWY-A nrPDB 131 7e-31 3F8P-A nrPDB 128 6e-30 1Q1R-A nrPDB 128 7e-30 4ZN0-A nrPDB 127 1e-29 2Q7V-A nrPDB 122 4e-28 3LXD-A nrPDB 120 2e-27 6BWT-A nrPDB 117 1e-26 1F6M-A nrPDB 116 2e-26 5U63-A nrPDB 115 3e-26 4YRY-B nrPDB 112 3e-25 5JFC-L nrPDB 111 9e-25 5W4C-A nrPDB 110 2e-24 5USX-A nrPDB 109 3e-24 4FX9-A nrPDB 109 4e-24 3D8X-A nrPDB 108 4e-24 5VJ7-A nrPDB 106 3e-23 6BPY-A nrPDB 105 6e-23 4CBQ-A nrPDB 104 8e-23 3ISH-A nrPDB 104 1e-22 1XHC-A nrPDB 103 3e-22 3AB1-A nrPDB 99 3e-21 4YKF-A nrPDB 98 7e-21 1FL2-A nrPDB 95 7e-20 3R9U-A nrPDB 94 1e-19 1VDC-A nrPDB 93 3e-19 2ZBW-A nrPDB 92 5e-19 3LZX-A nrPDB 92 5e-19 5KVH-A nrPDB 92 8e-19 5YGQ-A nrPDB 91 1e-18 5XHU-A nrPDB 89 4e-18 5MIU-A nrPDB 88 8e-18 5M5J-A nrPDB 87 2e-17 6GAR-A nrPDB 86 3e-17 4JNQ-A nrPDB 85 6e-17 3KLJ-A nrPDB 85 8e-17 2WHD-A nrPDB 83 2e-16 2VDC-G nrPDB 77 2e-14 6GAS-A nrPDB 77 3e-14 5TWC-A nrPDB 74 1e-13 4OVI-A nrPDB 70 2e-12 4G74-A nrPDB 68 1e-11 5NA1-A nrPDB 67 2e-11 3UP5-A nrPDB 66 4e-11 4NTC-A nrPDB 63 2e-10 3K30-A nrPDB 60 2e-09 4FK1-A nrPDB 60 3e-09 1PS9-A nrPDB 58 6e-09 5JWC-A nrPDB 58 7e-09 2CVJ-A nrPDB 56 3e-08 6A37-A nrPDB 56 4e-08 2TMD-A nrPDB 56 5e-08 4C5O-A nrPDB 55 1e-07 4USR-A nrPDB 54 2e-07 3H8L-A nrPDB 54 2e-07 6JDK-A nrPDB 52 5e-07 5NMX-A nrPDB 51 1e-06 1NAA-A nrPDB 49 6e-06 5BR7-A nrPDB 48 7e-06 3RHA-A nrPDB 47 2e-05 3HYW-A nrPDB 46 2e-05 3NIX-A nrPDB 46 3e-05 6ER9-A nrPDB 46 3e-05 5J7X-A nrPDB 46 4e-05 3KVE-A nrPDB 45 9e-05 4RG3-A nrPDB 45 1e-04 5EQD-A nrPDB 45 1e-04 2BXR-A nrPDB 45 1e-04 3T14-A nrPDB 45 1e-04 6CR0-A nrPDB 44 1e-04 1REO-A nrPDB 44 1e-04 4TLZ-A nrPDB 44 1e-04 4Y4N-A nrPDB 44 2e-04 1Y56-A nrPDB 44 2e-04 1O5W-A nrPDB 44 2e-04 4Y4M-A nrPDB 44 2e-04 4C3X-A nrPDB 43 2e-04 4AP1-A nrPDB 43 2e-04 2GAG-A nrPDB 43 4e-04 2VVL-G nrPDB 43 4e-04 4TXK-A nrPDB 43 4e-04 2BRY-A nrPDB 43 4e-04 3NK2-X nrPDB 42 5e-04 1F8S-A nrPDB 42 5e-04 3MJ4-A nrPDB 42 5e-04 5GSN-A nrPDB 42 5e-04 1I8T-A nrPDB 42 5e-04 3BHF-A nrPDB 42 7e-04 2JB2-A nrPDB 41 0.001 3ABT-A nrPDB 41 0.001 5L3D-A nrPDB 41 0.001 2GMH-A nrPDB 41 0.001 1ZOV-A nrPDB 41 0.001 5CQF-A nrPDB 41 0.002 2UZZ-A nrPDB 40 0.002 4MO2-B nrPDB 40 0.003 3KYB-A nrPDB 40 0.003 3UKH-A nrPDB 40 0.003 5MOG-A nrPDB 40 0.003 1VRQ-A nrPDB 40 0.004 3ATQ-A nrPDB 39 0.004 1QO8-A nrPDB 39 0.004 2VOU-A nrPDB 39 0.004 1SEZ-A nrPDB 39 0.005 3IHG-A nrPDB 39 0.005 5L46-A nrPDB 39 0.006 4Z2R-A nrPDB 39 0.006 4DGK-A nrPDB 39 0.006 6BRD-A nrPDB 38 0.009 1F14-A nrPDB 38 0.010 6MO6-A nrPDB 38 0.013 6HNS-A nrPDB 38 0.014 4A6N-B nrPDB 38 0.014 3HDH-A nrPDB 37 0.016 2VHY-A nrPDB 37 0.017 4IV9-A nrPDB 37 0.020 3WE0-A nrPDB 37 0.020 4EIQ-A nrPDB 37 0.021 6C6P-A nrPDB 37 0.025 3S61-A nrPDB 37 0.025 5KXJ-A nrPDB 36 0.030 4MOP-A nrPDB 36 0.030 2ZXH-A nrPDB 36 0.031 1RP0-A nrPDB 36 0.031 6ACQ-A nrPDB 36 0.037 1C0L-A nrPDB 36 0.038 4RPJ-A nrPDB 36 0.039 6H3G-A nrPDB 36 0.041 4H7U-A nrPDB 36 0.048 3G5Q-A nrPDB 36 0.051 3BI4-A nrPDB 35 0.064 5AYV-A nrPDB 35 0.070 3SM8-A nrPDB 35 0.10 1KSU-A nrPDB 35 0.11 6HRD-A nrPDB 35 0.11 3COX-A nrPDB 35 0.11 1D4E-A nrPDB 35 0.11 2QA2-A nrPDB 35 0.11 3HWR-A nrPDB 35 0.11 1DOD-A nrPDB 35 0.12 5X6R-A nrPDB 35 0.12 3CP8-A nrPDB 34 0.13 1KNR-A nrPDB 34 0.13 4K2X-A nrPDB 34 0.15 3OZ2-A nrPDB 34 0.15 4B68-A nrPDB 34 0.15 6J0Z-C nrPDB 34 0.16 5XGV-A nrPDB 34 0.17 2E5V-A nrPDB 34 0.18 4P9S-A nrPDB 34 0.19 5KOX-A nrPDB 34 0.20 2GRJ-A nrPDB 33 0.23 2DKH-A nrPDB 33 0.24 5I68-A nrPDB 33 0.24 1LTX-R nrPDB 33 0.25 4UIR-A nrPDB 33 0.26 3FPZ-A nrPDB 33 0.26 4IVM-B nrPDB 33 0.27 3LOV-A nrPDB 33 0.27 2XVH-A nrPDB 33 0.28 1FOH-A nrPDB 33 0.29 5EZ7-A nrPDB 33 0.29 3JSK-A nrPDB 33 0.31 3CP2-A nrPDB 33 0.31 4Z44-A nrPDB 33 0.31 3L1R-A nrPDB 33 0.34 4IA5-A nrPDB 33 0.37 5TUM-A nrPDB 33 0.46 6FZI-A nrPDB 32 0.48 6DLL-A nrPDB 32 0.50 5TUK-A nrPDB 32 0.55 4U2L-A nrPDB 32 0.56 2GAG-B nrPDB 32 0.58 5H82-A nrPDB 32 0.62 5TUL-A nrPDB 32 0.63 4XRR-A nrPDB 32 0.63 2Y0D-A nrPDB 32 0.64 2GV8-A nrPDB 32 0.64 1X14-A nrPDB 32 0.64 3HN2-A nrPDB 32 0.67 1E3J-A nrPDB 32 0.68 3KKJ-A nrPDB 32 0.68 3OJO-A nrPDB 32 0.81 4ZCC-A nrPDB 31 0.86 5XMJ-A nrPDB 31 0.98 5X68-A nrPDB 31 1.1 2YFH-A nrPDB 31 1.1 5ZYN-B nrPDB 31 1.2 3G05-A nrPDB 31 1.2 4A7P-A nrPDB 31 1.2 2BS2-A nrPDB 31 1.3 3IHM-A nrPDB 31 1.4 3RP7-A nrPDB 31 1.4 3GG2-A nrPDB 31 1.4 5TUF-A nrPDB 31 1.5 4K22-A nrPDB 31 1.5 5W1A-A nrPDB 31 1.6 4R16-A nrPDB 31 1.8 5OC1-A nrPDB 31 1.8 4KUG-A nrPDB 30 1.9 1XJ5-A nrPDB 30 1.9 2IVE-A nrPDB 30 2.1 3K96-A nrPDB 30 2.3 4FWE-A nrPDB 30 2.3 4Z25-A nrPDB 30 2.4 4B4O-A nrPDB 30 2.4 3OML-A nrPDB 30 2.6 3K6J-A nrPDB 30 2.7 2CZG-A nrPDB 30 2.8 4IIN-A nrPDB 30 2.8 1XFD-A nrPDB 30 2.9 4PJ1-A nrPDB 30 3.0 4MIF-A nrPDB 30 3.0 4X4J-A nrPDB 30 3.1 2EEZ-A nrPDB 30 3.2 1QP8-A nrPDB 30 3.2 5NCC-A nrPDB 30 3.5 4FHN-X nrPDB 30 3.5 2F1K-A nrPDB 30 3.5 5U4H-A nrPDB 30 3.6 4UDQ-A nrPDB 30 3.6 4HA6-A nrPDB 30 3.8 3KYD-B nrPDB 30 3.9 3KYC-B nrPDB 30 3.9 2X3N-A nrPDB 30 3.9 5EB4-A nrPDB 30 4.0 5PGZ-A nrPDB 29 4.1 5Y77-A nrPDB 29 4.3 3I6D-A nrPDB 29 4.5 2EW2-A nrPDB 29 4.5 2CDC-A nrPDB 29 4.7 4YNU-A nrPDB 29 4.9 3LLV-A nrPDB 29 5.1 4G65-A nrPDB 29 5.2 2AP9-A nrPDB 29 5.2 4DIO-A nrPDB 29 5.3 4CPD-A nrPDB 29 5.3 2CUL-A nrPDB 29 5.6 2B76-A nrPDB 29 5.7 4D3F-A nrPDB 29 6.1 3WSV-A nrPDB 29 6.6 3MOG-A nrPDB 29 6.6 1GPE-A nrPDB 29 6.8 6IUM-B nrPDB 28 7.4 3GNQ-A nrPDB 28 9.1 1Y6J-A nrPDB 28 9.1 5VM2-A nrPDB 28 9.7 2QK4-A nrPDB 28 9.8 >5J5Z-A nrPDB Length = 496 Score = 633 bits (1634), Expect = 0.0, Method: Composition-based stats. Identities = 473/474 (99%), Positives = 473/474 (99%) Query: 36 ADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNS 95 ADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNS Sbjct: 23 ADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNS 82 Query: 96 HYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGK 155 HYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGK Sbjct: 83 HYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGK 142 Query: 156 ITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEK 215 ITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEK Sbjct: 143 ITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEK 202 Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN Sbjct: 203 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 262 Query: 276 TKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRG 335 TKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRG Sbjct: 263 TKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRG 322 Query: 336 RIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYT 395 RIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYT Sbjct: 323 RIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYT 382 Query: 396 HPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHI 455 HPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHI Sbjct: 383 HPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHI 442 Query: 456 LGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF 509 LGPGAGEMVNEAALALEYGASCE IARVCHAHPTLSEAFREANLAASFGKSINF Sbjct: 443 LGPGAGEMVNEAALALEYGASCEVIARVCHAHPTLSEAFREANLAASFGKSINF 496 >3URH-A nrPDB Length = 491 Score = 532 bits (1370), Expect = e-151, Method: Composition-based stats. Identities = 260/477 (54%), Positives = 331/477 (69%), Gaps = 6/477 (1%) Query: 35 YADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNN 94 Y + D+ VIGSGPGGYV AIKAAQLG K +EK T GGTCLNVGCIPSKALL+ Sbjct: 19 YFQSMMAYDLIVIGSGPGGYVCAIKAAQLGMKVAVVEKRSTYGGTCLNVGCIPSKALLHA 78 Query: 95 SHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYG 154 S +H A + G+E++ +LNL KMM K VK+ G++ LFK+NK+ G G Sbjct: 79 SEMFHQAQ-HGLEALGVEVANPKLNLQKMMAHKDATVKSNVDGVSFLFKKNKIDGFQGTG 137 Query: 155 KITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGIT--IDEDTIVSSTGALSLKKV 212 K+ G+ +V+ T G QV++ KN++IATGS+V PG+ DE TIVSSTGAL+L+KV Sbjct: 138 KVLGQGKVSVTNEKGEEQVLEAKNVVIATGSDVAGIPGVEVAFDEKTIVSSTGALALEKV 197 Query: 213 PEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKF 272 P M+V+G GVIG+ELGSVW RLGA VT VEFL + G G+D E++K QR+L KQG F Sbjct: 198 PASMIVVGGGVIGLELGSVWARLGAKVTVVEFLDTILG-GMDGEVAKQLQRMLTKQGIDF 256 Query: 273 KLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELD 332 KL KVTGA K DG V+ E GG+A + +V+L+ GR+P T LGL + G+ LD Sbjct: 257 KLGAKVTGAVKSGDGA-KVTFEPVKGGEATTLDAEVVLIATGRKPSTDGLGLAKAGVVLD 315 Query: 333 PRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSV 392 RGR+ ++ FQT I +YAIGDVV GPMLAHKAEDEG+ E +AG A H++Y+ +P V Sbjct: 316 SRGRVEIDRHFQTSIAGVYAIGDVVRGPMLAHKAEDEGVAVAEIIAGQAGHVNYDVIPGV 375 Query: 393 IYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLG 452 +YT PEVA VGK+EE+LK G+ YK+GKFPF AN RA+ TDG VKIL K TDRVLG Sbjct: 376 VYTQPEVASVGKTEEELKAAGVAYKIGKFPFTANGRARAMLQTDGFVKILADKETDRVLG 435 Query: 453 AHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF 509 HI+G GAGEM++E A+ +E+G S ED+ R CHAHPT+SEA +EA L+ F K I+ Sbjct: 436 GHIIGFGAGEMIHEIAVLMEFGGSSEDLGRTCHAHPTMSEAVKEAALSTFF-KPIHM 491 >1DXL-A nrPDB Length = 470 Score = 527 bits (1359), Expect = e-150, Method: Composition-based stats. Identities = 268/469 (57%), Positives = 350/469 (74%), Gaps = 4/469 (0%) Query: 41 DADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHM 100 + DV +IG GPGGYVAAIKAAQLGFKT CIEK LGGTCLNVGCIPSKALL++SH YH Sbjct: 6 ENDVVIIGGGPGGYVAAIKAAQLGFKTTCIEKRGALGGTCLNVGCIPSKALLHSSHMYHE 65 Query: 101 AHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKN 160 A FA+ G+++S V ++L MM QK AV LT GI LFK+NKV +V GYGK + Sbjct: 66 AK-HSFANHGVKVSNVEIDLAAMMGQKDKAVSNLTRGIEGLFKKNKVTYVKGYGKFVSPS 124 Query: 161 QVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIG 220 +++ +G V+ K+I+IATGS+V PG+TIDE IVSSTGAL+L ++P+K+VVIG Sbjct: 125 EISVDTIEGENTVVKGKHIIIATGSDVKSLPGVTIDEKKIVSSTGALALSEIPKKLVVIG 184 Query: 221 AGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTG 280 AG IG+E+GSVW R+G++VT VEF + +D EI K FQR L+KQG KFKL TKV G Sbjct: 185 AGYIGLEMGSVWGRIGSEVTVVEFASEIVPT-MDAEIRKQFQRSLEKQGMKFKLKTKVVG 243 Query: 281 ATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVN 340 DG + +++E ++GG+ +I DV+LV GR PFT L L+++G+E D GRI VN Sbjct: 244 VDTSGDG-VKLTVEPSAGGEQTIIEADVVLVSAGRTPFTSGLNLDKIGVETDKLGRILVN 302 Query: 341 TRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVA 400 RF T + +YAIGDV+ GPMLAHKAE++G+ CVE +AG H+DY+ VP V+YT+PEVA Sbjct: 303 ERFSTNVSGVYAIGDVIPGPMLAHKAEEDGVACVEYLAGKVGHVDYDKVPGVVYTNPEVA 362 Query: 401 WVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGA 460 VGK+EEQ+KE G+EY+VGKFPF ANSRAK + +G+VKI+ +K TD++LG HI+ P A Sbjct: 363 SVGKTEEQVKETGVEYRVGKFPFMANSRAKAIDNAEGLVKIIAEKETDKILGVHIMAPNA 422 Query: 461 GEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF 509 GE+++EAA+AL+Y AS EDIARVCHAHPT+SEA +EA +A ++ K I+ Sbjct: 423 GELIHEAAIALQYDASSEDIARVCHAHPTMSEAIKEAAMA-TYDKPIHI 470 >5U8W-A nrPDB Length = 481 Score = 526 bits (1355), Expect = e-150, Method: Composition-based stats. Identities = 234/480 (48%), Positives = 314/480 (65%), Gaps = 12/480 (2%) Query: 36 ADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEK------NETLGGTCLNVGCIPSK 89 + DV VIG+GPGGYVAAI+AAQLG KT CIEK LGGTCLNVGCIPSK Sbjct: 2 SHMSQKFDVVVIGAGPGGYVAAIRAAQLGLKTACIEKYIGKEGKVALGGTCLNVGCIPSK 61 Query: 90 ALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVH 149 ALL++S+ YH A + F GIE V +++ M+ +K+ VK LTGGIA LFK N V Sbjct: 62 ALLDSSYKYHEAK-EAFKVHGIEAKGVTIDVPAMVARKANIVKNLTGGIATLFKANGVTS 120 Query: 150 VNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSL 209 G+GK+ QV T DG TQV++ +N++IA+GS P + +D IV STGAL Sbjct: 121 FEGHGKLLANKQVEVTGLDGKTQVLEAENVIIASGSRPVEIPPAPLTDDIIVDSTGALEF 180 Query: 210 KKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQG 269 + VP+K+ VIGAGVIG+ELGSVW RLGA+VT +E L D +I+K ++L KQG Sbjct: 181 QAVPKKLGVIGAGVIGLELGSVWARLGAEVTVLEALDKFLPAA-DEQIAKEALKVLTKQG 239 Query: 270 FKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGI 329 +L +VT + K ++ V+ A+G + E T D L+V +GRRP T +L + G+ Sbjct: 240 LNIRLGARVTASEVKK-KQVTVTFTDANGEQKE--TFDKLIVAVGRRPVTTDLLAADSGV 296 Query: 330 ELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCV 389 LD RG I V+ +T +P ++AIGDVV G MLAHKA +EG++ E +AG ++Y+ + Sbjct: 297 TLDERGFIYVDDHCKTSVPGVFAIGDVVRGAMLAHKASEEGVMVAERIAGHKAQMNYDLI 356 Query: 390 PSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDR 449 PSVIYTHPE+AWVGK+E+ LK EG+E VG FPFAA+ RA DT G+VK++ TDR Sbjct: 357 PSVIYTHPEIAWVGKTEQTLKAEGVEVNVGTFPFAASGRAMAANDTTGLVKVIADAKTDR 416 Query: 450 VLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF 509 VLG H++GP A E+V + A+ +E+G S ED+ + +HPTLSEA EA LA + G +I+ Sbjct: 417 VLGVHVIGPSAAELVQQGAIGMEFGTSAEDLGMMVFSHPTLSEALHEAALAVN-GHAIHI 475 >1V59-A nrPDB Length = 478 Score = 522 bits (1346), Expect = e-148, Method: Composition-based stats. Identities = 270/474 (56%), Positives = 350/474 (73%), Gaps = 11/474 (2%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 102 DV +IG GP GYVAAIKAAQLGF T C+EK LGGTCLNVGCIPSKALLNNSH +H H Sbjct: 7 DVVIIGGGPAGYVAAIKAAQLGFNTACVEKRGKLGGTCLNVGCIPSKALLNNSHLFHQMH 66 Query: 103 GKDFASRGIEM-SEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQ 161 + RGI++ ++++N+ + K AVK LTGGI LFK+NKV + G G + + Sbjct: 67 T-EAQKRGIDVNGDIKINVANFQKAKDDAVKQLTGGIELLFKKNKVTYYKGNGSFEDETK 125 Query: 162 VTATKADGGT------QVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEK 215 + T DG ++D KNI++ATGSEVTPFPGI IDE+ IVSSTGALSLK++P++ Sbjct: 126 IRVTPVDGLEGTVKEDHILDVKNIIVATGSEVTPFPGIEIDEEKIVSSTGALSLKEIPKR 185 Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 + +IG G+IG+E+GSV+ RLG+ VT VEF +G +D E++K Q+ L+KQG FKL+ Sbjct: 186 LTIIGGGIIGLEMGSVYSRLGSKVTVVEFQPQIGA-SMDGEVAKATQKFLKKQGLDFKLS 244 Query: 276 TKVTGATKKSDGKI-DVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPR 334 TKV A + D + ++ +E K E + +VLLV +GRRP+ LG E++G+E+D R Sbjct: 245 TKVISAKRNDDKNVVEIVVEDTKTNKQENLEAEVLLVAVGRRPYIAGLGAEKIGLEVDKR 304 Query: 335 GRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIY 394 GR+ ++ +F +K P+I +GDV GPMLAHKAE+EGI VE + G H++YN +PSV+Y Sbjct: 305 GRLVIDDQFNSKFPHIKVVGDVTFGPMLAHKAEEEGIAAVEMLKTGHGHVNYNNIPSVMY 364 Query: 395 THPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAH 454 +HPEVAWVGK+EEQLKE GI+YK+GKFPFAANSRAKTN DT+G VKIL T+R+LGAH Sbjct: 365 SHPEVAWVGKTEEQLKEAGIDYKIGKFPFAANSRAKTNQDTEGFVKILIDSKTERILGAH 424 Query: 455 ILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSIN 508 I+GP AGEM+ EA LALEYGAS ED+ARVCHAHPTLSEAF+EAN+AA K+I+ Sbjct: 425 IIGPNAGEMIAEAGLALEYGASAEDVARVCHAHPTLSEAFKEANMAAY-DKAIH 477 >5TR3-A nrPDB Length = 481 Score = 520 bits (1339), Expect = e-148, Method: Composition-based stats. Identities = 233/473 (49%), Positives = 310/473 (65%), Gaps = 11/473 (2%) Query: 39 PIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNE------TLGGTCLNVGCIPSKALL 92 DV VIG+GPGGYVAAIKAAQLG KT CIEK LGGTCLNVGCIPSKALL Sbjct: 5 TQKFDVVVIGAGPGGYVAAIKAAQLGLKTACIEKYTDAEGKLALGGTCLNVGCIPSKALL 64 Query: 93 NNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNG 152 ++S Y A + F GI EV++++ M+ +K+ VK LTGG+A LFK N V + G Sbjct: 65 DSSWKYKEAK-ESFNVHGISTGEVKMDVAAMVGRKAGIVKNLTGGVATLFKANGVTSIQG 123 Query: 153 YGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKV 212 +GK+ +V TKADG T+VI+ +N+++A+GS P +D++ IV STGAL + V Sbjct: 124 HGKLLAGKKVEVTKADGTTEVIEAENVILASGSRPIDIPPAPVDQNVIVDSTGALEFQAV 183 Query: 213 PEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKF 272 P+++ VIGAGVIG+ELGSVW RLGA+VT +E L + D +SK Q+ L KQG Sbjct: 184 PKRLGVIGAGVIGLELGSVWARLGAEVTVLEALDTFL-MAADTAVSKEAQKTLTKQGLDI 242 Query: 273 KLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELD 332 KL +VTG+ + +V + + + IT D L+V +GRRP T +L + G+ +D Sbjct: 243 KLGARVTGSKVNGN---EVEVTYTNAEGEQKITFDKLIVAVGRRPVTTDLLASDSGVTID 299 Query: 333 PRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSV 392 RG I V+ T +P +YAIGDVV G MLAHKA +EGI+ VE + G ++Y+ +PSV Sbjct: 300 ERGYIFVDDYCATSVPGVYAIGDVVRGMMLAHKASEEGIMVVERIKGHKAQMNYDLIPSV 359 Query: 393 IYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLG 452 IYTHPE+AWVGK+E+ LK EG+E VG FPFAA+ RA DT G VK++ TDRVLG Sbjct: 360 IYTHPEIAWVGKTEQALKAEGVEVNVGTFPFAASGRAMAANDTGGFVKVIADAKTDRVLG 419 Query: 453 AHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGK 505 H++GP A E+V + A+A+E+G S ED+ + +HPTLSEA EA LA + G Sbjct: 420 VHVIGPSAAELVQQGAIAMEFGTSAEDLGMMVFSHPTLSEALHEAALAVNGGA 472 >3LAD-A nrPDB Length = 476 Score = 514 bits (1325), Expect = e-146, Method: Composition-based stats. Identities = 231/474 (48%), Positives = 311/474 (65%), Gaps = 12/474 (2%) Query: 41 DADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNE------TLGGTCLNVGCIPSKALLNN 94 DV VIG+GPGGYVAAIK+AQLG KT IEK + LGGTCLNVGCIPSKALL++ Sbjct: 3 KFDVIVIGAGPGGYVAAIKSAQLGLKTALIEKYKGKEGKTALGGTCLNVGCIPSKALLDS 62 Query: 95 SHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYG 154 S+ +H AH + F GI EV +++ M+ +K V+ LTGG+A L K N V G+G Sbjct: 63 SYKFHEAH-ESFKLHGISTGEVAIDVPTMIARKDQIVRNLTGGVASLIKANGVTLFEGHG 121 Query: 155 KITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPE 214 K+ +V T ADG +QV+DT+N+++A+GS+ P +D+D IV STGAL + VP Sbjct: 122 KLLAGKKVEVTAADGSSQVLDTENVILASGSKPVEIPPAPVDQDVIVDSTGALDFQNVPG 181 Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL 274 K+ VIGAGVIG+ELGSVW RLGA+VT +E + +D +++K Q+IL KQG K L Sbjct: 182 KLGVIGAGVIGLELGSVWARLGAEVTVLEAMDKFLP-AVDEQVAKEAQKILTKQGLKILL 240 Query: 275 NTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPR 334 +VTG K + ++ V A G K++ D L+V +GRRP T +L + G+ LD R Sbjct: 241 GARVTGTEVK-NKQVTVKFVDAEGEKSQ--AFDKLIVAVGRRPVTTDLLAADSGVTLDER 297 Query: 335 GRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIY 394 G I V+ T +P +YAIGDVV G MLAHKA +EG++ E +AG ++Y+ +P+VIY Sbjct: 298 GFIYVDDYCATSVPGVYAIGDVVRGAMLAHKASEEGVVVAERIAGHKAQMNYDLIPAVIY 357 Query: 395 THPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAH 454 THPE+A VGK+E+ LK EG+ VG FPFAA+ RA DT G VK++ TDRVLG H Sbjct: 358 THPEIAGVGKTEQALKAEGVAINVGVFPFAASGRAMAANDTAGFVKVIADAKTDRVLGVH 417 Query: 455 ILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSIN 508 ++GP A E+V + A+A+E+G S ED+ + AHP LSEA EA LA G +I+ Sbjct: 418 VIGPSAAELVQQGAIAMEFGTSAEDLGMMVFAHPALSEALHEAALAV-SGHAIH 470 >6BZ0-A nrPDB Length = 480 Score = 500 bits (1287), Expect = e-142, Method: Composition-based stats. Identities = 211/473 (44%), Positives = 296/473 (62%), Gaps = 11/473 (2%) Query: 41 DADVTVIGSGPGGYVAAIKAAQLGFKTVCIEK-----NETLGGTCLNVGCIPSKALLNNS 95 D+ VIG GPGGY AAI+AAQLGFK CIEK +LGGTCLNVGCIPSKALL++S Sbjct: 7 QFDLVVIGGGPGGYEAAIRAAQLGFKVACIEKRIHNGKPSLGGTCLNVGCIPSKALLDSS 66 Query: 96 HYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGK 155 H Y A GI EV +L K++ +K V LTGGI L K N + + G GK Sbjct: 67 HRYE-DTVHHLADHGITTGEVNFDLAKLLARKDKIVDQLTGGIDQLLKGNGIEWLKGTGK 125 Query: 156 ITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEK 215 + +V +G TQ+++ K +++A+GS P +D+D IV STGAL+ +VP++ Sbjct: 126 LLAGKKVEFVPHEGETQILEPKYVILASGSVPVNIPVAPVDQDIIVDSTGALNFPEVPKR 185 Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 + VIGAGVIG+ELGSVW+RLGA+V E + + D +SK +Q+IL KQG ++ Sbjct: 186 LGVIGAGVIGLELGSVWRRLGAEVVVFEAMDAFLPMA-DKALSKEYQKILTKQGLDIRIG 244 Query: 276 TKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRG 335 KV+G +V+++ G+ + T D L+VC+GR+ + + L E+ GI+L RG Sbjct: 245 AKVSGTEVNG---REVTVKYTQAGEDKEQTFDKLIVCVGRKAYAEGLLAEDSGIKLTERG 301 Query: 336 RIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYT 395 + VN T + +YAIGD+V GPMLAHKA +EG++ VE + G A ++Y+ + S+IYT Sbjct: 302 LVEVNDHCATSVEGVYAIGDLVRGPMLAHKAMEEGVMAVERIHGHAAQVNYDTIISIIYT 361 Query: 396 HPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHI 455 HPE AWVG +EEQ KE+G E K G+F FA N RA + G VK + TDR+LG H+ Sbjct: 362 HPEAAWVGLTEEQAKEKGHEVKTGQFGFAVNGRALAAGEGAGFVKFVADAKTDRLLGMHV 421 Query: 456 LGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSIN 508 +GP A ++V++ +ALE+ +S ED+ + HPT SE EA LA G++I+ Sbjct: 422 IGPAASDIVHQGMIALEFVSSVEDLQLMTFGHPTFSEVVHEAALAVD-GRAIH 473 >2YQU-A nrPDB Length = 455 Score = 496 bits (1277), Expect = e-140, Method: Composition-based stats. Identities = 211/460 (45%), Positives = 298/460 (64%), Gaps = 13/460 (2%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMA 101 D+ VIG+GPGGYVAAI+AAQLG K +EK + LGGTCL VGCIPSKALL + + A Sbjct: 2 YDLLVIGAGPGGYVAAIRAAQLGMKVGVVEKEKALGGTCLRVGCIPSKALLETTERIYEA 61 Query: 102 HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQ 161 G ++ V L+L +M K V+A T G+ LFK+N + G + + + Sbjct: 62 KK---GLLGAKVKGVELDLPALMAHKDKVVQANTQGVEFLFKKNGIARHQGTARFLSERK 118 Query: 162 VTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGA 221 V + + ++ + ILIATGS P +D + +V+ST ALS +VP++++V+G Sbjct: 119 VLVEE---TGEELEARYILIATGSAPLIPPWAQVDYERVVTSTEALSFPEVPKRLIVVGG 175 Query: 222 GVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGA 281 GVIG+ELG VW RLGA+V +E++ + +D+E+S+ +R+ +KQG + +VT Sbjct: 176 GVIGLELGVVWHRLGAEVIVLEYMDRILPT-MDLEVSRAAERVFKKQGLTIRTGVRVTAV 234 Query: 282 TKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNT 341 ++ G V +E EV+ D +LV +GRRP+T+ L LE G+ D RGRIPV+ Sbjct: 235 VPEAKGA-RVELEG-----GEVLEADRVLVAVGRRPYTEGLSLENAGLSTDERGRIPVDE 288 Query: 342 RFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAW 401 +T++P+IYAIGDVV GPMLAHKA +EGI VE M G H+DY +PSV+YTHPE+A Sbjct: 289 HLRTRVPHIYAIGDVVRGPMLAHKASEEGIAAVEHMVRGFGHVDYQAIPSVVYTHPEIAA 348 Query: 402 VGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAG 461 VG +EE+LK +GI YKVGKFP++A+ RA+ +T+G +K+L TDR+LG H +G G Sbjct: 349 VGYTEEELKAQGIPYKVGKFPYSASGRARAMGETEGFIKVLAHAKTDRILGVHGIGARVG 408 Query: 462 EMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAA 501 +++ EAALAL + AS ED+ R HAHP+LSE +EA LAA Sbjct: 409 DVLAEAALALFFKASAEDLGRAPHAHPSLSEILKEAALAA 448 >6N7F-A nrPDB Length = 453 Score = 495 bits (1276), Expect = e-140, Method: Composition-based stats. Identities = 126/463 (27%), Positives = 202/463 (43%), Gaps = 19/463 (4%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYH 99 I D VIG G G +A +AA G K + E + +GGTC+N+GC+P K + + Sbjct: 6 IPYDYIVIGGGSAGIASANRAAMHGAKVLLAE-GKEIGGTCVNLGCVPKKVMWYGAQVAD 64 Query: 100 MAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGK 159 + G G + E + ++ + + + F+QN V + Y Sbjct: 65 IL-GTYAKDYGFDFKEKAFDFKQLKANRQAYIDRIHASYERGFEQNGVDRIYDYAVFKDA 123 Query: 160 NQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVI 219 + V Q+ +ILIATG FP I + +SS G +L +VP++ V+ Sbjct: 124 HTVEIA-----GQLYTAPHILIATGGHPV-FPDIEGAQ-YGISSDGFFALDEVPKRTAVV 176 Query: 220 GAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVT 279 GAG I VEL V LG+ D I + G + + +V Sbjct: 177 GAGYIAVELAGVLHALGSKTDLFIRHDR-PLRSFDKTIVDVLVDEMAVNGPRLHTHAEVA 235 Query: 280 GATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPV 339 K +D + + ++ + + D L+ IGR+P + L++ G+ L+ +G I Sbjct: 236 KVVKNTDESLTLYLKD-----GQEVEVDQLIWAIGRKPNLEGFSLDKTGVTLNDKGYIET 290 Query: 340 NTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAV--HIDYNCVPSVIYTHP 397 + T + IYA+GDV L A G E + G +DY V +VI++HP Sbjct: 291 DAYENTSVKGIYAVGDVNGKLALTPVAVAAGRRLSERLFNGKTDEKLDYQNVATVIFSHP 350 Query: 398 EVAWVGKSEEQL-KEEGIE-YKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHI 455 + VG SEE K+ G E K + F + A TN ++K++ T++++G H Sbjct: 351 VIGSVGLSEEAAVKQYGQEAVKTYQSRFTSMFTAITNHRQPCLMKLVTVGDTEKIVGLHG 410 Query: 456 LGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREAN 498 +G G EM+ A+A++ GA+ D HPT SE F Sbjct: 411 IGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR 453 >5VDN-A nrPDB Length = 463 Score = 492 bits (1267), Expect = e-139, Method: Composition-based stats. Identities = 117/444 (26%), Positives = 199/444 (44%), Gaps = 19/444 (4%) Query: 59 KAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRL 118 +AA G K IE + LGGTC+NVGC+P K + + + H G + + Sbjct: 35 RAAMYGKKCALIEAKQ-LGGTCVNVGCVPKKVMWHAAQIAEAIHLY-GPDYGFDTTVNHF 92 Query: 119 NLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKN 178 + K++ ++ + + NKV + G+ + + V + I + Sbjct: 93 DWKKLIANRTAYIDRIHQSYERGLGNNKVDVIQGFARFVDAHTVEV-----NGETITADH 147 Query: 179 ILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGAD 238 ILIATG + P I E + S G L ++P+++ V+GAG I VE+ V LG + Sbjct: 148 ILIATGGRPSH-PDIPGAE-YGIDSDGFFELDEMPKRVAVVGAGYIAVEIAGVLNGLGTE 205 Query: 239 VTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASG 298 T + H D I + ++ +G K + K +DG + + +E Sbjct: 206 -THLFVRKHAPLRTFDPLIVETLLEVMNTEGPKLHTESVPKAVIKNADGSLTLQLE---- 260 Query: 299 GKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVA 358 +T D L+ IGR P T NL L G++ + +G I V+ T + IYA+GD Sbjct: 261 -NGTEVTVDHLIWAIGREPATDNLNLSVTGVKTNDKGYIEVDKFQNTNVKGIYAVGDNTG 319 Query: 359 GPMLAHKAEDEGIICVEGMAGGAV--HIDYNCVPSVIYTHPEVAWVGKSEEQLKEE--GI 414 L A G E + H+DY+ +P+V+++HP + +G +E Q +E+ Sbjct: 320 VVELTPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIGTIGLTEPQAREKFGDD 379 Query: 415 EYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYG 474 + KV F A A T +K++ + ++++G H +G G E++ A+A++ G Sbjct: 380 QVKVYTSSFTAMYSAVTQHRQPCRMKLVCVGAEEKIVGIHGIGFGMDEILQGFAVAMKMG 439 Query: 475 ASCEDIARVCHAHPTLSEAFREAN 498 A+ +D HPT +E F Sbjct: 440 ATKKDFDNTVAIHPTAAEEFVTMR 463 >1GEU-A nrPDB Length = 450 Score = 492 bits (1266), Expect = e-139, Method: Composition-based stats. Identities = 125/446 (28%), Positives = 202/446 (45%), Gaps = 23/446 (5%) Query: 59 KAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRL 118 +AA G K IE E LGGTC+NVGC+P K + + + H G + + + Sbjct: 22 RAAMYGQKCALIEAKE-LGGTCVNVGCVPKKVMWHAAQIREAIHMY-GPDYGFDTTINKF 79 Query: 119 NLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKN 178 N + ++ ++ + + ++ +N V + G+ + + + I + Sbjct: 80 NWETLIASRTAYIDRIHTSYENVLGKNNVDVIKGFARFVDAKTLEV-----NGETITADH 134 Query: 179 ILIATGSEV--TPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLG 236 ILIATG PG+ + + S G +L +PE++ V+GAG IGVELG V LG Sbjct: 135 ILIATGGRPSHPDIPGV----EYGIDSDGFFALPALPERVAVVGAGYIGVELGGVINGLG 190 Query: 237 ADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAA 296 A E D IS+ ++ +G + N K +DG + + +E Sbjct: 191 AKTHLFEMFDAPLP-SFDPMISETLVEVMNAEGPQLHTNAIPKAVVKNTDGSLTLELED- 248 Query: 297 SGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDV 356 T D L+ IGR P N+ LE G++ + +G I V+ T I IYA+GD Sbjct: 249 ----GRSETVDCLIWAIGREPANDNINLEAAGVKTNEKGYIVVDKYQNTNIEGIYAVGDN 304 Query: 357 VAGPMLAHKAEDEGIICVEGMAGGAV--HIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGI 414 L A G E + H+DY+ +P+V+++HP + VG +E Q +E+ Sbjct: 305 TGAVELTPVAVAAGRRLSERLFNNKPDEHLDYSNIPTVVFSHPPIGTVGLTEPQAREQYG 364 Query: 415 E--YKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALE 472 + KV K F A A T +K++ S ++++G H +G G EM+ A+AL+ Sbjct: 365 DDQVKVYKSSFTAMYTAVTTHRQPCRMKLVCVGSEEKIVGIHGIGFGMDEMLQGFAVALK 424 Query: 473 YGASCEDIARVCHAHPTLSEAFREAN 498 GA+ +D HPT +E F Sbjct: 425 MGATKKDFDNTVAIHPTAAEEFVTMR 450 >2QAE-A nrPDB Length = 468 Score = 491 bits (1265), Expect = e-139, Method: Composition-based stats. Identities = 243/457 (53%), Positives = 314/457 (68%), Gaps = 8/457 (1%) Query: 56 AAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSE 115 A+IKAAQLG KT C+EK LGGTCLNVGCIPSKALL+ +H YH AH FA G+ E Sbjct: 17 ASIKAAQLGMKTACVEKRGALGGTCLNVGCIPSKALLHATHLYHDAHAN-FARYGLMGGE 75 Query: 116 -VRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVI 174 V ++ KM +QK AVK LTGG+ +LFK+NKV + G G + + DG +++ Sbjct: 76 GVTMDSAKMQQQKERAVKGLTGGVEYLFKKNKVTYYKGEGSFETAHSIRVNGLDGKQEML 135 Query: 175 DTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQR 234 +TK +IATGSE T P + DE ++SSTGAL+L +VP+ MVVIG GVIG+ELGSVW R Sbjct: 136 ETKKTIIATGSEPTELPFLPFDEKVVLSSTGALALPRVPKTMVVIGGGVIGLELGSVWAR 195 Query: 235 LGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQG-FKFKLNTKVTGATKKSDGKIDVSI 293 LGA+VT VEF +D +++ L K KF +TKV G T D + + + Sbjct: 196 LGAEVTVVEFAPRCAPT-LDEDVTNALVGALAKNEKMKFMTSTKVVGGTNNGD-SVSLEV 253 Query: 294 EAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAI 353 E GK E +TC+ LLV +GRRPFT LGL+++ + + RG + + F+T IP++YAI Sbjct: 254 E-GKNGKRETVTCEALLVSVGRRPFTGGLGLDKINVAKNERGFVKIGDHFETSIPDVYAI 312 Query: 354 GDVVA-GPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEE 412 GDVV GPMLAHKAEDEG+ C E +AG H++Y +P+VIYT PEVA VGKSE++LK+E Sbjct: 313 GDVVDKGPMLAHKAEDEGVACAEILAGKPGHVNYGVIPAVIYTMPEVASVGKSEDELKKE 372 Query: 413 GIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALE 472 G+ YKVGKFPF ANSRAK + DG VK+L K+TDR+LG HI+ AGE++ EA LA+E Sbjct: 373 GVAYKVGKFPFNANSRAKAVSTEDGFVKVLVDKATDRILGVHIVCTTAGELIGEACLAME 432 Query: 473 YGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF 509 YGAS ED+ R CHAHPT+SEA +EA +A F K+INF Sbjct: 433 YGASSEDVGRTCHAHPTMSEALKEACMAL-FAKTINF 468 >1EBD-A nrPDB Length = 455 Score = 490 bits (1263), Expect = e-139, Method: Composition-based stats. Identities = 201/459 (43%), Positives = 278/459 (60%), Gaps = 9/459 (1%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYH 99 I+ + V+G+GPGGYVAAI+AAQLG K +EK LGG CLNVGCIPSKAL++ SH Y Sbjct: 2 IETETLVVGAGPGGYVAAIRAAQLGQKVTIVEKG-NLGGVCLNVGCIPSKALISASHRYE 60 Query: 100 MAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGK 159 A K GI+ V ++ K+ E K++ VK LTGG+ L K NKV V G Sbjct: 61 QA--KHSEEMGIKAENVTIDFAKVQEWKASVVKKLTGGVEGLLKGNKVEIVKGEAYFVDA 118 Query: 160 NQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVI 219 N V D Q KN +IATGS P + I+ STGAL+L +VP+ +VVI Sbjct: 119 NTVRVVNGD-SAQTYTFKNAIIATGSRPIELPNFKF-SNRILDSTGALNLGEVPKSLVVI 176 Query: 220 GAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVT 279 G G IG+ELG+ + G VT +E G + G + +++ ++ L+K+G + N Sbjct: 177 GGGYIGIELGTAYANFGTKVTILEGAGEILS-GFEKQMAAIIKKRLKKKGVEVVTNALAK 235 Query: 280 GATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPV 339 GA ++ DG V++ + G+ + I D +LV +GRRP T LGLE++GI++ RG I V Sbjct: 236 GAEEREDG---VTVTYEANGETKTIDADYVLVTVGRRPNTDELGLEQIGIKMTNRGLIEV 292 Query: 340 NTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEV 399 + + +T +PNI+AIGD+V GP LAHKA EG + E +AG +DY +P+V+++ PE Sbjct: 293 DQQCRTSVPNIFAIGDIVPGPALAHKASYEGKVAAEAIAGHPSAVDYVAIPAVVFSDPEC 352 Query: 400 AWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPG 459 A VG E+Q K+EGI+ KFPFAAN RA DTDG +K++ +K ++GA I+GP Sbjct: 353 ASVGYFEQQAKDEGIDVIAAKFPFAANGRALALNDTDGFLKLVVRKEDGVIIGAQIIGPN 412 Query: 460 AGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREAN 498 A +M+ E LA+E G + EDIA HAHPTL E EA Sbjct: 413 ASDMIAELGLAIEAGMTAEDIALTIHAHPTLGEIAMEAA 451 >1ZDL-A nrPDB Length = 517 Score = 490 bits (1261), Expect = e-139, Method: Composition-based stats. Identities = 137/479 (28%), Positives = 219/479 (45%), Gaps = 20/479 (4%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET--------LGGTCLNVGCIPSKALLN 93 D+ VIG G GG A +AAQLG K + E LGGTC+NVGCIP K + Sbjct: 33 FDLLVIGGGSGGLACAKEAAQLGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQ 92 Query: 94 NSHYYHMAHGKDFASRGIEMSE-VRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNG 152 + M G E+++ V+ N M E VK+L G + KV + N Sbjct: 93 AALLGGMIRDAHH--YGWEVAQPVQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKYFNI 150 Query: 153 YGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKV 212 ++ V G ++ ++I+IATG + + ++S LK+ Sbjct: 151 KASFVDEHTVRGVDKGGKATLLSAEHIVIATGGRPRYPTQVKGALEYGITSDDIFWLKES 210 Query: 213 PEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKF 272 P K +V+GA + +E +G D T + + + G D ++S ++ G +F Sbjct: 211 PGKTLVVGASYVALECAGFLTGIGLDTTVM--MRSIPLRGFDQQMSSLVTEHMESHGTQF 268 Query: 273 KLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELD 332 + K ++ V+ E + GK + T D +L IGR P T+ L LE+ GI + Sbjct: 269 LKGCVPSHIKKLPTNQLQVTWEDHASGKEDTGTFDTVLWAIGRVPETRTLNLEKAGISTN 328 Query: 333 PRG-RIPVNTRFQTKIPNIYAIGDVVAG-PMLAHKAEDEGIICVEGMAGGAVH-IDYNCV 389 P+ +I V+ + T +P+IYAIGDV G P L A G + + + G + +DY+ V Sbjct: 329 PKNQKIIVDAQEATSVPHIYAIGDVAEGRPELTPTAIKAGKLLAQRLFGKSSTLMDYSNV 388 Query: 390 PSVIYTHPEVAWVGKSEEQL----KEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQK 445 P+ ++T E VG SEE+ +E +E + + A +A + + ++ Sbjct: 389 PTTVFTPLEYGCVGLSEEEAVALHGQEHVEVYHAYYKPLEFTVADRDASQCYIKMVCMRE 448 Query: 446 STDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFG 504 VLG H LGP AGE+ AL ++ GAS + + HPT SE + +++ G Sbjct: 449 PPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMQTVGIHPTCSEEVVKLHISKRSG 507 >2X8H-A nrPDB Length = 598 Score = 485 bits (1248), Expect = e-137, Method: Composition-based stats. Identities = 142/493 (28%), Positives = 219/493 (44%), Gaps = 28/493 (5%) Query: 37 DQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET--------LGGTCLNVGCIPS 88 + D D+ VIG G GG A +AA+ G KT ++ E LGGTC+NVGCIP Sbjct: 103 ESKYDYDLIVIGGGSGGLAAGKEAAKYGAKTAVLDYVEPTPIGTTWGLGGTCVNVGCIPK 162 Query: 89 KALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVV 148 K + H + ++ S++ N M+E + + +L G + N+V Sbjct: 163 KLMHQAGLLSHALEDAEHFGWSLDRSKISHNWSTMVEGVQSHIGSLNWGYKVALRDNQVT 222 Query: 149 HVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALS 208 ++N G++ ++V T + I I++ATG E +P I + ++S S Sbjct: 223 YLNAKGRLISPHEVQITDKNQKVSTITGNKIILATG-ERPKYPEIPGAVEYGITSDDLFS 281 Query: 209 LKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQ 268 L P K +VIGA + +E LG DVT + + + G D ++++ ++ Sbjct: 282 LPYFPGKTLVIGASYVALECAGFLASLGGDVTVM--VRSILLRGFDQQMAEKVGDYMENH 339 Query: 269 GFKF--------KLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTK 320 G KF KV G + V G K E + ++ +GR P Sbjct: 340 GVKFAKLCVPDEIKQLKVVDTENNKPGLLLVKGHYTDGKKFEE-EFETVIFAVGREPQLS 398 Query: 321 NLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAG-PMLAHKAEDEGIICVEGMAG 379 + E +G++LD GR+ QT + N+YAIGD+ AG P L A G + Sbjct: 399 KVLCETVGVKLDKNGRVVCTDDEQTTVSNVYAIGDINAGKPQLTPVAIQAGRYLARRLFA 458 Query: 380 GAVHI-DYNCVPSVIYTHPEVAWVGKSEEQLKEEG----IEYKVGKFPFAANSRAKTNAD 434 GA + DY+ V + ++T E G SEE E+ IE F + A D Sbjct: 459 GATELTDYSNVATTVFTPLEYGACGLSEEDAIEKYGDKDIEVYHSNFKPLEWTVAHRE-D 517 Query: 435 TDGMVKILGQK-STDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEA 493 +K++ +K RVLG H+LGP AGE+ A+A++ GA+ D R HPT SE Sbjct: 518 NVCYMKLVCRKSDNMRVLGLHVLGPNAGEITQGYAVAIKMGATKADFDRTIGIHPTCSET 577 Query: 494 FREANLAASFGKS 506 F ++ G S Sbjct: 578 FTTLHVTKKSGVS 590 >6AON-A nrPDB Length = 478 Score = 481 bits (1238), Expect = e-136, Method: Composition-based stats. Identities = 222/477 (46%), Positives = 305/477 (63%), Gaps = 13/477 (2%) Query: 41 DADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNE------TLGGTCLNVGCIPSKALLNN 94 DV VIG+GPGGY+AAI+AAQLG CI+ + GGTC NVGCIPSKALL + Sbjct: 7 QFDVVVIGAGPGGYIAAIRAAQLGMSVACIDAWQNGQGGPAPGGTCTNVGCIPSKALLQS 66 Query: 95 SHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYG 154 S +Y A FA GIE+ V L LD ++ +K+T VK GI +LFK+NKV + +G G Sbjct: 67 SEHYEQA-NHHFAEHGIEVKGVSLKLDTLIGRKNTVVKQNNDGILYLFKKNKVTYFHGKG 125 Query: 155 KITGK-NQVTATKADGGTQV-IDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKV 212 G+ + + K G T + K++++ATGS PG+ DE I+S+ GAL++ V Sbjct: 126 AFAGQVDGGWSIKVTGTTDADLVAKHVIVATGSSARELPGLPFDEKNILSNDGALNIGAV 185 Query: 213 PEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKF 272 P+K+ VIGAGVIG+E+GSVW+RLGA+VT +E + D +++K + KQG Sbjct: 186 PKKLGVIGAGVIGLEMGSVWRRLGAEVTILEAMPEFLAAA-DQQVAKEALKSFAKQGLDI 244 Query: 273 KLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELD 332 + K+ G K + I V A G + + + D L+V IGR P+T L E +G++LD Sbjct: 245 QTGVKI-GEIKAAAKSITVPYVDAKGAE-QKLVVDKLIVSIGRVPYTGGLNAEAVGLKLD 302 Query: 333 PRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSV 392 RG + V+ +T +PN++A+GDVV GPMLAHKAE+EG+ E +AG H+++ VP V Sbjct: 303 ERGFVAVDEDCKTNLPNVWAVGDVVRGPMLAHKAEEEGVAVAERIAGQHGHVNFATVPWV 362 Query: 393 IYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLG 452 IYT PE+AWVGK+E+QLK EG EYK G FPF AN RA+ DT G K++ TD VLG Sbjct: 363 IYTSPEIAWVGKTEQQLKAEGREYKAGSFPFMANGRARALGDTTGFAKVIADAKTDEVLG 422 Query: 453 AHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF 509 HI+GP A E+++EA +E+ + EDIAR+CHAHPTLSEA +EA LA +++NF Sbjct: 423 VHIIGPMASELISEAVTIMEFRGAAEDIARICHAHPTLSEAVKEAALAVD-KRTLNF 478 >4LA1-A nrPDB Length = 602 Score = 478 bits (1231), Expect = e-135, Method: Composition-based stats. Identities = 131/472 (27%), Positives = 205/472 (43%), Gaps = 28/472 (5%) Query: 58 IKAAQLGFKTVCIEKNET--------LGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASR 109 +AA+ G K ++ E LGGTC+NVGCIP K + H Sbjct: 130 KEAAKYGAKIAVLDYVEPTPMGTTWGLGGTCVNVGCIPKKLMHQAGLLSHSLEDAQHFGW 189 Query: 110 GIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADG 169 ++ SE+ + M+E + + +L G + N V ++N G + ++V T+ + Sbjct: 190 SLDKSEISHDWSTMVEGVQSHIGSLNWGYKVSLRDNAVTYLNARGMLLSPHEVQITEKNK 249 Query: 170 GTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELG 229 I I++ATG E +P I + ++S SL P K +V+GA + ++ Sbjct: 250 KVSTITGNKIILATG-ERPKYPEIPGAIEYGITSDDLFSLPYFPGKTLVVGASYVALKCA 308 Query: 230 SVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKF--------KLNTKVTGA 281 LG DVT + + + G D ++++ ++ G KF K Sbjct: 309 GFLASLGGDVTVM--VRSILLRGFDQQMAEKVGDYMENHGVKFAKLCVPDEITQLKPVDT 366 Query: 282 TKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNT 341 G + V G K E + ++ +GR P L E +G++LD GR+ + Sbjct: 367 ENNKPGLLLVKGHYTDGKKFEE-EFETVIFAVGREPQLSKLNCEAVGVKLDKNGRVVCSD 425 Query: 342 RFQTKIPNIYAIGDVVAG-PMLAHKAEDEGIICVEGMAGGAVHI-DYNCVPSVIYTHPEV 399 QT + NIYAIGD+ AG P L A G + GA + DY+ V + ++T E Sbjct: 426 DEQTTVSNIYAIGDINAGKPQLTPVAIHAGRYLARRLFAGATELTDYSNVATTVFTPLEY 485 Query: 400 AWVGKSEEQLKEEG----IEYKVGKFPFAANSRAKTNADTDGMVKILGQ-KSTDRVLGAH 454 G SEE E+ IE F + A D +K++ + RVLG H Sbjct: 486 GACGLSEEDAIEKYGDNDIEVYHSHFKPLEWTVAHRE-DNVCYMKLVCRISDNMRVLGLH 544 Query: 455 ILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKS 506 +LGP AGE+ A+A++ GA+ ED R HPT SE F ++ G S Sbjct: 545 VLGPNAGEITQGYAVAIKMGATKEDFDRTIGIHPTCSETFTTLHVTKRSGGS 596 >4JDR-A nrPDB Length = 474 Score = 475 bits (1223), Expect = e-134, Method: Composition-based stats. Identities = 199/459 (43%), Positives = 271/459 (59%), Gaps = 7/459 (1%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYH 99 I V V+G+GP GY AA + A LG +TV +E+ TLGG CLNVGCIPSKALL+ + Sbjct: 5 IKTQVVVLGAGPAGYSAAFRCADLGLETVIVERYNTLGGVCLNVGCIPSKALLHVAKVIE 64 Query: 100 MAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGK 159 A A GI E + ++DK+ K + LTGG+A + K KV VNG GK TG Sbjct: 65 EAKA--LAEHGIVFGEPKTDIDKIRTWKEKVINQLTGGLAGMAKGRKVKVVNGLGKFTGA 122 Query: 160 NQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVI 219 N + +G T VI+ N +IA GS P I ++ I ST AL LK+VPE+++V+ Sbjct: 123 NTLEVEGENGKT-VINFDNAIIAAGSRPIQLPFIPHEDPRIWDSTDALELKEVPERLLVM 181 Query: 220 GAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVT 279 G G+IG+E+G+V+ LG+ + VE V D +I K F + + K+ F L TKVT Sbjct: 182 GGGIIGLEMGTVYHALGSQIDVVEMFDQVIPAA-DKDIVKVFTKRISKK-FNLMLETKVT 239 Query: 280 GATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPV 339 K DG I V++E AE D +LV IGR P KNL + G+E+D RG I V Sbjct: 240 AVEAKEDG-IYVTMEGKKAP-AEPQRYDAVLVAIGRVPNGKNLDAGKAGVEVDDRGFIRV 297 Query: 340 NTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEV 399 + + +T +P+I+AIGD+V PMLAHK EG + E +AG + D +PS+ YT PEV Sbjct: 298 DKQLRTNVPHIFAIGDIVGQPMLAHKGVHEGHVAAEVIAGKKHYFDPKVIPSIAYTEPEV 357 Query: 400 AWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPG 459 AWVG +E++ KE+GI Y+ FP+AA+ RA + DGM K++ K + RV+G I+G Sbjct: 358 AWVGLTEKEAKEKGISYETATFPWAASGRAIASDCADGMTKLIFDKESHRVIGGAIVGTN 417 Query: 460 AGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREAN 498 GE++ E LA+E G EDIA HAHPTL E+ A Sbjct: 418 GGELLGEIGLAIEMGCDAEDIALTIHAHPTLHESVGLAA 456 >2R9Z-A nrPDB Length = 463 Score = 475 bits (1223), Expect = e-134, Method: Composition-based stats. Identities = 125/466 (26%), Positives = 212/466 (45%), Gaps = 23/466 (4%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMA 101 D+ IG G GG A KAA G + IE ++ LGGTC+NVGC+P K + SH Sbjct: 5 FDLIAIGGGSGGLAVAEKAAAFGKRVALIE-SKALGGTCVNVGCVPKKVMWYASHLAEAV 63 Query: 102 HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQ 161 +D G++ S L+ +++ + + A+ ++ + V+G+ + + Sbjct: 64 --RDAPGFGVQASGGTLDWPRLVAGRDRYIGAINSFWDGYVERLGITRVDGHARFVDAHT 121 Query: 162 VTATKADGGTQVIDTKNILIATGSEV--TPFPGITIDEDTIVSSTGALSLKKVPEKMVVI 219 + Q + +I+IATG PG + ++S G +L++ P+++ +I Sbjct: 122 IEV-----EGQRLSADHIVIATGGRPIVPRLPGAELG----ITSDGFFALQQQPKRVAII 172 Query: 220 GAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVT 279 GAG IG+EL + + G++VT V D +S + QG + L V Sbjct: 173 GAGYIGIELAGLLRSFGSEVTVVALEDR-LLFQFDPLLSATLAENMHAQGIETHLEFAVA 231 Query: 280 GATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPV 339 + + G ++ A G + E D ++ +GR P T++LGLE GIE+ G +P Sbjct: 232 ALERDAQG---TTLVAQDGTRLE--GFDSVIWAVGRAPNTRDLGLEAAGIEVQSNGMVPT 286 Query: 340 NTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAV--HIDYNCVPSVIYTHP 397 + T +P +YA+GD+ L A G E + G +DY+ +P+V++ HP Sbjct: 287 DAYQNTNVPGVYALGDITGRDQLTPVAIAAGRRLAERLFDGQSERKLDYDNIPTVVFAHP 346 Query: 398 EVAWVGKSEEQLKEE-GIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHIL 456 ++ VG SE + +E G V + F A +K++ RV+G H++ Sbjct: 347 PLSKVGLSEPEARERLGDVLTVYETSFTPMRYALNEHGPKTAMKLVCAGPEQRVVGVHVI 406 Query: 457 GPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAAS 502 G GA EM+ A+A++ GA+ D HP +E Sbjct: 407 GDGADEMLQGFAVAVKMGATKADFDNTVAIHPGSAEELVTLKEPVR 452 >6B4O-A nrPDB Length = 452 Score = 470 bits (1211), Expect = e-133, Method: Composition-based stats. Identities = 134/467 (28%), Positives = 211/467 (45%), Gaps = 19/467 (4%) Query: 36 ADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNS 95 ++ D VIG G GG +A +A G + IE NE +GGTC+NVGC+P K + S Sbjct: 1 SNAMKTYDYIVIGGGSGGIASANRAGMHGANVLLIEGNE-IGGTCVNVGCVPKKVMWQAS 59 Query: 96 HYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGK 155 M +D A G ++ + +++E + + L G N + ++GY Sbjct: 60 SMMEMME-RDTAGYGFDVEIKNFSFKQLVENREKYIDFLHGAYNRGLDSNNIERIHGYAT 118 Query: 156 ITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEK 215 TG+ + + +ILIATG GI E+ + S G +L+++P++ Sbjct: 119 FTGEQTIEVNGTE-----YTAPHILIATGGRPKKL-GIPG-EEYALDSNGFFALEEMPKR 171 Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 +V +GAG I EL LGA+ T F D +S+ Q+ G + N Sbjct: 172 VVFVGAGYIAAELAGTLHGLGAE-THWAFRHERPLRSFDDMLSEKVVERYQEMGMQIHPN 230 Query: 276 TKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRG 335 K + + ++ E E IT D ++ GR+P T LGLE + LD +G Sbjct: 231 ATPAKIEKTAQNEYVITFE-----NGESITTDAVIFGTGRQPNTDQLGLENTKVALDEKG 285 Query: 336 RIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAV--HIDYNCVPSVI 393 + V+ T IYA+GDV+ L A G E + G ++DYN VP+V+ Sbjct: 286 YVKVDKFQNTTQNGIYAVGDVIGKIDLTPVAIAAGRRLSERLFNGQTDLYLDYNLVPTVV 345 Query: 394 YTHPEVAWVGKSEEQLKEEGIE--YKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVL 451 +THP VA +G +E+ EE E K+ + F A +K++ ++++ Sbjct: 346 FTHPPVATIGLTEKAALEEYGEDQVKIYRSSFTPMYFALGEYRQKCDMKLICVGKEEKIV 405 Query: 452 GAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREAN 498 G H +G G EM+ A+A++ GA+ D HPT SE F Sbjct: 406 GLHGIGIGVDEMLQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR 452 >5U1O-A nrPDB Length = 458 Score = 470 bits (1211), Expect = e-133, Method: Composition-based stats. Identities = 113/445 (25%), Positives = 191/445 (42%), Gaps = 20/445 (4%) Query: 59 KAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRL 118 +AA G K IE + LGGTC+NVGC+P K + + + + G ++ Sbjct: 29 RAAMYGAKVALIEA-QDLGGTCVNVGCVPKKVMWHGAQIAEAMNLY-AEDYGFDVDVKGF 86 Query: 119 NLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKN 178 + K++E + + + + NKV + G+ K + V + + Sbjct: 87 DWSKLVESRQAYIGRIHQSYDRVLGNNKVNVIKGFAKFVDEKTVEV-----NGEHYTADH 141 Query: 179 ILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGAD 238 ILIA G T P I E + S G L + P+++ V+GAG I VE+ V LG + Sbjct: 142 ILIAVGGRPT-IPNIPGAE-YGIDSNGFFDLAEQPKRVAVVGAGYIAVEIAGVLHALGTE 199 Query: 239 VTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASG 298 T + D I +++ +G ++ K++DG + + +E Sbjct: 200 -THLFVRKESPLRSFDPMIIDTLVEVMEAEGPTLHTHSVPKEVVKEADGSLTLHLE---- 254 Query: 299 GKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVV- 357 E D L+ IGR P T + L G+ + +G I V+ +T + IY +GD++ Sbjct: 255 -NGESQNVDQLIWAIGRHPATDAINLASTGVATNEKGYIKVDEYQETNVKGIYCVGDIME 313 Query: 358 AGPMLAHKAEDEGIICVEGMAGGAV--HIDYNCVPSVIYTHPEVAWVGKSEEQLKEEG-- 413 G L A G E + +DY+ VP+V+++HP + +G + ++ +E+ Sbjct: 314 GGIELTPVAVKAGRQLSERLFNNKPNAKMDYDLVPTVVFSHPPIGTIGLTTQEAEEKYGK 373 Query: 414 IEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEY 473 KV F A A T +K++ + V+G H +G EM+ +A++ Sbjct: 374 DNIKVYTSGFTAMYTAVTKHRQPCKMKLVCAGEEETVVGLHGIGFTVDEMIQGFGVAMKM 433 Query: 474 GASCEDIARVCHAHPTLSEAFREAN 498 GA+ D V HPT SE F Sbjct: 434 GATKADFDSVVAIHPTGSEEFVTMR 458 >4KPR-E nrPDB Length = 499 Score = 469 bits (1207), Expect = e-132, Method: Composition-based stats. Identities = 133/471 (28%), Positives = 225/471 (47%), Gaps = 28/471 (5%) Query: 58 IKAAQLGFKTVCIEKNET--------LGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASR 109 +AA+ K + ++ LGGTC+NVGCIP K + + KD + Sbjct: 29 KEAAKFDKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQAL--KDSRNY 86 Query: 110 GIEMSE-VRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKAD 168 G ++ + V+ + +KM E + +L G ++ KVV+ N YGK G +++ AT Sbjct: 87 GWKLEDTVKHDWEKMTESVQNHIGSLNWGYRVALREKKVVYENAYGKFIGPHKIMATNNK 146 Query: 169 GGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVEL 228 G +V + LIATG GI D++ +SS SL P K +V+GA + +E Sbjct: 147 GKEKVYSAERFLIATGERPRYL-GIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALEC 205 Query: 229 GSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKF---KLNTKVTGATKKS 285 +G DVT + + + G D +++ +++ G KF + TK+ + Sbjct: 206 AGFLAGIGLDVTVM--VRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPTKIEQIEAGT 263 Query: 286 DGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPR-GRIPVNTRFQ 344 G++ V+ ++ + + + +L+ +GR T+ +GLE +G++++ + G+IPV Q Sbjct: 264 PGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTIGLETVGVKINEKTGKIPVTDEEQ 323 Query: 345 TKIPNIYAIGDVVAG-PMLAHKAEDEGIICVEGMAGGAV-HIDYNCVPSVIYTHPEVAWV 402 T +P IYAIGD++ G L A G + + + GG+ DY+ VP+ ++T E Sbjct: 324 TNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTVKCDYDNVPTTVFTPLEYGCC 383 Query: 403 GKSEEQL----KEEGIEYKVGKF-PFAANSRAKTNADTDGMVKILGQ-KSTDRVLGAHIL 456 G SEE+ EE IE F P ++ N K++ K +RV+G H+L Sbjct: 384 GLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDNNK--CYAKVICNLKDNERVVGFHVL 441 Query: 457 GPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSI 507 GP AGE+ A AL+ G + + + HP +E F ++ G I Sbjct: 442 GPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTTLSVTKRSGGDI 492 >2AAQ-A nrPDB Length = 479 Score = 469 bits (1207), Expect = e-132, Method: Composition-based stats. Identities = 138/470 (29%), Positives = 222/470 (47%), Gaps = 25/470 (5%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMA 101 D VIG G GG +A +AA+LG + +E ++ LGGTC+NVGC+P K + N + + Sbjct: 22 YDYLVIGGGSGGLASARRAAELGARAAVVESHK-LGGTCVNVGCVPKKVMWNTAVHSEFM 80 Query: 102 HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQ 161 H D A G E + N + E++ V L + ++ + + G+ T + Sbjct: 81 H--DHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDPK 138 Query: 162 VTATKADGGTQVIDTKNILIATGSEVT-----PFPGITIDEDTIVSSTGALSLKKVPEKM 216 T + + +ILIATG + PG ++ ++S G L+++P + Sbjct: 139 PTI---EVSGKKYTAPHILIATGGMPSTPHESQIPGASLG----ITSDGFFQLEELPGRS 191 Query: 217 VVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNT 276 V++GAG I VE+ + LG+ + + V D IS N L+ G + + Sbjct: 192 VIVGAGYIAVEMAGILSALGSKTSLMIRHDKVL-RSFDSMISTNCTEELENAGVEVLKFS 250 Query: 277 KVTGATKKSDGKIDVSIEAASGGKAEVIT----CDVLLVCIGRRPFTKNLGLEELGIELD 332 +V K G ++VS+ A G+ V+T D LL IGR P TK+L L +LGI+ D Sbjct: 251 QVKEVKKTLSG-LEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTD 309 Query: 333 PRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAG--GAVHIDYNCVP 390 +G I V+ T + IYA+GDV +L A G + +DYN +P Sbjct: 310 DKGHIIVDEFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIP 369 Query: 391 SVIYTHPEVAWVGKSEEQL-KEEGIE-YKVGKFPFAANSRAKTNADTDGMVKILGQKSTD 448 +V+++HP + VG +E++ + GIE K F A T T ++K++ + Sbjct: 370 TVVFSHPPIGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEE 429 Query: 449 RVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREAN 498 +V+G H+ G G EM+ A+A++ GA+ D HPT SE Sbjct: 430 KVVGIHMQGLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR 479 >2CFY-A nrPDB Length = 521 Score = 467 bits (1203), Expect = e-132, Method: Composition-based stats. Identities = 133/471 (28%), Positives = 223/471 (47%), Gaps = 28/471 (5%) Query: 58 IKAAQLGFKTVCIEKNET--------LGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASR 109 +AAQ G K + ++ LGGTC+NVGCIP K + + +D + Sbjct: 51 KEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQAL--QDSRNY 108 Query: 110 GIEMSE-VRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKAD 168 G ++ E V+ + D+M+E + +L G ++ KVV+ N YG+ G +++ AT Sbjct: 109 GWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNK 168 Query: 169 GGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVEL 228 G ++ + LIATG GI D++ +SS SL P K +V+GA + +E Sbjct: 169 GKEKIYSAERFLIATGERPRYL-GIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALEC 227 Query: 229 GSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKF---KLNTKVTGATKKS 285 +G DVT + + + G D +++ +++ G KF + KV + Sbjct: 228 AGFLAGIGLDVTVM--VRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGT 285 Query: 286 DGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPR-GRIPVNTRFQ 344 G++ V ++ + + + +++ IGR T+ +GLE +G++++ + G+IPV Q Sbjct: 286 PGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQ 345 Query: 345 TKIPNIYAIGDVVA-GPMLAHKAEDEGIICVEGMAGGAV-HIDYNCVPSVIYTHPEVAWV 402 T +P IYAIGD++ L A G + + + G+ DY VP+ ++T E Sbjct: 346 TNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGAC 405 Query: 403 GKSEEQL----KEEGIEYKVGKF-PFAANSRAKTNADTDGMVKILGQ-KSTDRVLGAHIL 456 G SEE+ EE IE F P ++ N KI+ K +RV+G H+L Sbjct: 406 GLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNNK--CYAKIICNTKDNERVVGFHVL 463 Query: 457 GPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSI 507 GP AGE+ A AL+ G + + + HP +E F ++ G SI Sbjct: 464 GPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASI 514 >2EQ6-A nrPDB Length = 464 Score = 467 bits (1201), Expect = e-132, Method: Composition-based stats. Identities = 207/460 (45%), Positives = 290/460 (63%), Gaps = 14/460 (3%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMA 101 D+ VIG+GPGGY AAI+AAQLG K + +E E +GG CLNVGCIP+KALL+ + H Sbjct: 7 YDLIVIGTGPGGYHAAIRAAQLGLKVLAVEAGE-VGGVCLNVGCIPTKALLHAAETLH-- 63 Query: 102 HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQ 161 H K G++ + L+L K+ + VK LTGG+ L K N V + G+ ++ G + Sbjct: 64 HLKVAEGFGLKA-KPELDLKKLGGWRDQVVKKLTGGVGTLLKGNGVELLRGFARLVGPKE 122 Query: 162 VTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKK-VPEKMVVIG 220 V G + K++++ATGSE G ED + ST AL +++ +P++++VIG Sbjct: 123 VEV-----GGERYGAKSLILATGSEPLELKGFPFGED-VWDSTRALKVEEGLPKRLLVIG 176 Query: 221 AGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTG 280 G +G+ELG V++RLGA+VT +E++ + G D E + +R L+K+G + + TK G Sbjct: 177 GGAVGLELGQVYRRLGAEVTLIEYMPEILPQG-DPETAALLRRALEKEGIRVRTKTKAVG 235 Query: 281 ATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVN 340 KK DG + V +E A GG+ E + D +LV +GR+P T+ LGLE+ G+++D RG I VN Sbjct: 236 YEKKKDG-LHVRLEPAEGGEGEEVVVDKVLVAVGRKPRTEGLGLEKAGVKVDERGFIRVN 294 Query: 341 TRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVA 400 R +T +P +YAIGD P+LAHKA EG+I E AG DY VPSV+YT PE A Sbjct: 295 ARMETSVPGVYAIGDAARPPLLAHKAMREGLIAAENAAGKDSAFDYQ-VPSVVYTSPEWA 353 Query: 401 WVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGA 460 VG +EE+ K G + KVGKFP AA+ RA T +GMVK++G + TD +LG I+GP A Sbjct: 354 GVGLTEEEAKRAGYKVKVGKFPLAASGRALTLGGAEGMVKVVGDEETDLLLGVFIVGPQA 413 Query: 461 GEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLA 500 GE++ EAALALE GA+ D+A H HPTLSE+ EA A Sbjct: 414 GELIAEAALALEMGATLTDLALTVHPHPTLSESLMEAAEA 453 >6DU7-A nrPDB Length = 448 Score = 464 bits (1194), Expect = e-131, Method: Composition-based stats. Identities = 119/446 (26%), Positives = 198/446 (44%), Gaps = 24/446 (5%) Query: 59 KAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRL 118 +A + G + IE+ + LGGTC+NVGC+P K + + H G + +++ Sbjct: 21 RAGEHGAQAAVIEEKK-LGGTCVNVGCVPKKIMWYGAQIAETFHQF-GEDYGFKTTDLNF 78 Query: 119 NLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKN 178 + + + + + FK+N V + G+ + + V+ ++I K+ Sbjct: 79 DFATLRRNRESYIDRARSSYDGSFKRNGVDLIEGHAEFVDSHTVSV-----NGELIRAKH 133 Query: 179 ILIATGSEV--TPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLG 236 I+IATG+ PG + SS + +++PE + ++GAG I VEL V G Sbjct: 134 IVIATGAHPSIPNIPGAELGG----SSDDVFAWEELPESVAILGAGYIAVELAGVLHTFG 189 Query: 237 ADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAA 296 G D I + + +++ + K +DG I + E Sbjct: 190 VKTDLFVRRDR-PLRGFDSYIVEGLVKEMERTNLPLHTHKVPVKLEKTTDG-ITIHFEDG 247 Query: 297 SGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDV 356 + T ++ GRRP K L LE+ G+ L+ RG I V+ T + IYA+GDV Sbjct: 248 TS-----HTASQVIWATGRRPNVKGLQLEKAGVTLNERGFIQVDEYQNTVVEGIYALGDV 302 Query: 357 VAGPMLAHKAEDEGIICVEGMAGGAV--HIDYNCVPSVIYTHPEVAWVGKSEEQLKEEG- 413 L A G E + G +DY+ +P+V+++HP + VG +EEQ +E Sbjct: 303 TGEKELTPVAIKAGRTLSERLFNGKTTAKMDYSTIPTVVFSHPAIGTVGLTEEQAIKEYG 362 Query: 414 -IEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALE 472 + KV K FA+ A T + K++ S ++V+G H +G G EM+ A+A++ Sbjct: 363 QDQIKVYKSSFASMYSACTRNRQESRFKLITAGSEEKVVGLHGIGYGVDEMIQGFAVAIK 422 Query: 473 YGASCEDIARVCHAHPTLSEAFREAN 498 GA+ D HPT SE F Sbjct: 423 MGATKADFDATVAIHPTSSEEFVTMR 448 >5V36-A nrPDB Length = 453 Score = 461 bits (1187), Expect = e-130, Method: Composition-based stats. Identities = 123/464 (26%), Positives = 194/464 (41%), Gaps = 19/464 (4%) Query: 39 PIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYY 98 D VIG G GG +A +AA G K + E + +GGTC+NVGC+P K + + Sbjct: 5 TKQYDYIVIGGGSGGIASANRAAMHGAKVILFEGKQ-VGGTCVNVGCVPKKVMWYGAQVA 63 Query: 99 HMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITG 158 + A G +++ + D + + + + + F N V V GY Sbjct: 64 ETINNY-AADYGFDVTTQAFHFDVLKQNRQAYIDRIHDSYERGFDSNGVERVYGYATFVD 122 Query: 159 KNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVV 218 + V + +ILIATG P I + ++S G L +P++ V Sbjct: 123 AHTVEVA-----GEHYTAPHILIATGGHAL-LPDIPG-SEYGITSDGFFELDAIPKRTAV 175 Query: 219 IGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKV 278 +GAG I VE+ + LG++ D EI ++K G + Sbjct: 176 VGAGYIAVEISGILHALGSETHLFVRRDR-PLRKFDKEIVGTLVDEMKKDGPHLHTFSVP 234 Query: 279 TGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIP 338 K +D + + +E E T D L+ IGR TK LE G+ LD RG I Sbjct: 235 KEVIKNTDNSLTLILE-----NGEEYTVDTLIWAIGRAANTKGFNLEVTGVTLDSRGFIA 289 Query: 339 VNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAV--HIDYNCVPSVIYTH 396 + T + +YA+GDV L A G E + +DY V +VI++H Sbjct: 290 TDAFENTNVEGLYALGDVNGKLELTPVAVKAGRQLSERLFNHKPQAKMDYKDVATVIFSH 349 Query: 397 PEVAWVGKSEEQLKEEGIE--YKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAH 454 P + +G SEE ++ E V + F + A T+ +K++ ++++G H Sbjct: 350 PVIGSIGLSEEAALDQYGEENVTVYRSTFTSMYTAVTSHRQACKMKLVTVGEDEKIVGLH 409 Query: 455 ILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREAN 498 +G G EM+ A+A++ GA+ D HPT SE F Sbjct: 410 GIGYGVDEMIQGFAVAIKMGATKADFDNTVAIHPTGSEEFVTMR 453 >2NVK-X nrPDB Length = 488 Score = 460 bits (1183), Expect = e-130, Method: Composition-based stats. Identities = 126/486 (25%), Positives = 217/486 (44%), Gaps = 23/486 (4%) Query: 37 DQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET---------LGGTCLNVGCIP 87 D D+ VIG G G A +A G + C++ + +GGTC+NVGCIP Sbjct: 5 QGSYDYDLIVIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIP 64 Query: 88 SKALLNNSHYYHMAHGKDFASRGIEMSE-VRLNLDKMMEQKSTAVKALTGGIAHLFKQNK 146 K + S H + A+ G + + ++ + K+++ +K++ + K Sbjct: 65 KKLMHQASLLGEAVH--EAAAYGWNVDDKIKPDWHKLVQSVQNHIKSVNWVTRVDLRDKK 122 Query: 147 VVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGA 206 V ++NG G + + A K G + I + +IA G +P I + ++S Sbjct: 123 VEYINGLGSFVDSHTLLA-KLKSGERTITAQTFVIAVGGRP-RYPDIPGAVEYGITSDDL 180 Query: 207 LSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQ 266 SL + P K +V+GAG IG+E + LG + T + + + G D ++++ ++ Sbjct: 181 FSLDREPGKTLVVGAGYIGLECAGFLKGLGYEPTVM--VRSIVLRGFDQQMAELVAASME 238 Query: 267 KQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEE 326 ++G F T K+ DGK+ V + G+ D +L IGR+ +L L Sbjct: 239 ERGIPFLRKTVPLSVEKQDDGKLLVKYKNVETGEESEDVYDTVLWAIGRKGLVDDLNLPN 298 Query: 327 LGIELDPRGRIPVNTRFQTKIPNIYAIGDVV-AGPMLAHKAEDEGIICVEGMAGGAV-HI 384 G+ + + +IPV+++ T + NIYA+GD++ P L A G + + GG+ + Sbjct: 299 AGVTV-QKDKIPVDSQEATNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRM 357 Query: 385 DYNCVPSVIYTHPEVAWVGKSEE----QLKEEGIEYKVGKFPFAANSRAKTNADTDGMVK 440 DY V + ++T E A VG SEE Q + IE G + + + + Sbjct: 358 DYKDVATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQKSVRYCYLKA 417 Query: 441 ILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLA 500 + + RV G H +GP AGE++ A AL+ G + + HPT +E F + Sbjct: 418 VAERHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLAIT 477 Query: 501 ASFGKS 506 G Sbjct: 478 KRSGLD 483 >2WOV-A nrPDB Length = 495 Score = 459 bits (1182), Expect = e-129, Method: Composition-based stats. Identities = 136/492 (27%), Positives = 214/492 (43%), Gaps = 35/492 (7%) Query: 36 ADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNE---------TLGGTCLNVGCI 86 + D+ VIG+G GG A AA L K V + + LGGTC+NVGC+ Sbjct: 2 SHMSKAFDLVVIGAGSGGLEAGWNAATLYGKRVAVVDVQTSHGPPFYAALGGTCVNVGCV 61 Query: 87 PSKALLNNSHYYHMAHGKDFASRGIEMSE--VRLNLDKMMEQKSTAVKALTGGIAHLFKQ 144 P K ++ + Y M H ++ A G E V+ N K++ K+ AV + +F Sbjct: 62 PKKLMVTGAQY--MDHLRESAGFGWEFDGSSVKANWKKLIAAKNEAVLDINKSYEGMFND 119 Query: 145 -NKVVHVNGYGKITGKNQV----TATKADGGTQVIDTKNILIATGSEV--TPFPGITIDE 197 + G+G + KN V TA + + +IL+ATGS PGI Sbjct: 120 TEGLDFFLGWGSLESKNVVVVRETADPKSAVKERLQADHILLATGSWPQMPAIPGI---- 175 Query: 198 DTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRL---GADVTAVEFLGHVGGVGID 254 + +SS A L + P +++ +G G I VE ++ G VT + ++ G D Sbjct: 176 EHCISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPPGGKVTLC-YRNNLILRGFD 234 Query: 255 MEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIG 314 I + + L G + N + +DG V+ E+ + DV+++ IG Sbjct: 235 ETIREEVTKQLTANGIEIMTNENPAKVSLNTDGSKHVTFESGK-----TLDVDVVMMAIG 289 Query: 315 RRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICV 374 R P T +L L +G++L P+G + V+ +T +PNIYAIGD+ ML A +EG V Sbjct: 290 RIPRTNDLQLGNVGVKLTPKGGVQVDEFSRTNVPNIYAIGDITDRLMLTPVAINEGAALV 349 Query: 375 EGMAGGAVH-IDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNA 433 + + G D+ V S +++ P + G EE +E + V F + + Sbjct: 350 DTVFGNKPRKTDHTRVASAVFSIPPIGTCGLIEEVAAKEFEKVAVYMSSFTPLMHNISGS 409 Query: 434 DTDGMV-KILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSE 492 V KI+ S VLG H+LG GA E++ + L A D HPT +E Sbjct: 410 KYKKFVAKIVTNHSDGTVLGVHLLGDGAPEIIQAVGVCLRLNAKISDFYNTIGVHPTSAE 469 Query: 493 AFREANLAASFG 504 + + Sbjct: 470 ELCSMRTPSYYY 481 >2HQM-A nrPDB Length = 479 Score = 458 bits (1179), Expect = e-129, Method: Composition-based stats. Identities = 132/470 (28%), Positives = 209/470 (44%), Gaps = 23/470 (4%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYY--- 98 D VIG G GG +A +AA G KT+ +E + LGGTC+NVGC+P K + S Sbjct: 12 YDYLVIGGGSGGVASARRAASYGAKTLLVEA-KALGGTCVNVGCVPKKVMWYASDLATRV 70 Query: 99 -HMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKIT 157 H + + ++ + N + +++ V L G ++ KV V G+ + Sbjct: 71 SHANEYGLYQNLPLDKEHLTFNWPEFKQKRDAYVHRLNGIYQKNLEKEKVDVVFGWARFN 130 Query: 158 GKNQVTATKADGGTQVIDTKNILIATGSE---VTPFPGITIDEDTIVSSTGALSLKKVPE 214 V K D T+V +IL+ATG + PG + D S G L++ P+ Sbjct: 131 KDGNVEVQKRDNTTEVYSANHILVATGGKAIFPENIPGFELGTD----SDGFFRLEEQPK 186 Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL 274 K+VV+GAG IG+EL V+ LG++ V G D I K+G Sbjct: 187 KVVVVGAGYIGIELAGVFHGLGSETHLV-IRGETVLRKFDECIQNTITDHYVKEGINVHK 245 Query: 275 NTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPR 334 +K+ K + ++ + D L+ IGR+ +G E +GI+L+ Sbjct: 246 LSKIVKVEKNVE---TDKLKIHMNDSKSIDDVDELIWTIGRKSHL-GMGSENVGIKLNSH 301 Query: 335 GRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAV----HIDYNCVP 390 +I + T +PNIY++GDVV L A G + G +DY VP Sbjct: 302 DQIIADEYQNTNVPNIYSLGDVVGKVELTPVAIAAGRKLSNRLFGPEKFRNDKLDYENVP 361 Query: 391 SVIYTHPEVAWVGKSEEQLKEEGIE--YKVGKFPFAANSRAKTNADTDGMVKILGQKSTD 448 SVI++HPE +G SE++ E+ + KV F A A + + KI+ + Sbjct: 362 SVIFSHPEAGSIGISEKEAIEKYGKENIKVYNSKFTAMYYAMLSEKSPTRYKIVCAGPNE 421 Query: 449 RVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREAN 498 +V+G HI+G + E++ +A++ GA+ D HPT +E Sbjct: 422 KVVGLHIVGDSSAEILQGFGVAIKMGATKADFDNCVAIHPTSAEELVTMR 471 >2YAU-A nrPDB Length = 511 Score = 453 bits (1165), Expect = e-127, Method: Composition-based stats. Identities = 131/492 (26%), Positives = 213/492 (43%), Gaps = 31/492 (6%) Query: 36 ADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET---------LGGTCLNVGCI 86 + D+ V+G+G GG A AA K V + + LGGTC+NVGC+ Sbjct: 19 SHMSRAYDLVVLGAGSGGLEAGWNAAVTHKKKVAVVDVQATHGPPLFAALGGTCVNVGCV 78 Query: 87 PSKALLNNSHYYHMAHGKDFASRGIEMSEVRL--NLDKMMEQKSTAVKALTGGIAHLFKQ 144 P K ++ + Y + ++ G EM L N ++ K+ V ++ +F Sbjct: 79 PKKLMVTGAQYMDLI--RESGGFGWEMDRESLCPNWKTLIAAKNKVVNSINESYKSMFAD 136 Query: 145 -NKVVHVNGYGKITGKNQVTATKADGGT----QVIDTKNILIATGSEVTPFPGITIDEDT 199 + G+G + + V K++ + +DT+ ILIATGS T G+ DE Sbjct: 137 TEGLSFHMGFGALQDAHTVVVRKSEDPHSDVLETLDTEYILIATGSWPTRL-GVPGDE-F 194 Query: 200 IVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRL---GADVTAVEFLGHVGGVGIDME 256 ++S A L+ P++M+ +G G I VE ++ G V + G + G D E Sbjct: 195 CITSNEAFYLEDAPKRMLCVGGGYIAVEFAGIFNGYKPCGGYVDLC-YRGDLILRGFDTE 253 Query: 257 ISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRR 316 + K+ + L G + + N T TK DG V D +++ IGR Sbjct: 254 VRKSLTKQLGANGIRVRTNLNPTKITKNEDGSNHVHF-----NDGTEEDYDQVMLAIGRV 308 Query: 317 PFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEG 376 P ++ L L++ G+ G + V+ +T + NIYAIGDV ML A +EG VE Sbjct: 309 PRSQALQLDKAGVRTGKNGAVQVDAYSKTSVDNIYAIGDVTNRVMLTPVAINEGAAFVET 368 Query: 377 MAGGAVH-IDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAA-NSRAKTNAD 434 + GG D+ V +++ P + G +EE+ + V F + Sbjct: 369 VFGGKPRATDHTKVACAVFSIPPIGTCGMTEEEAAKNYETVAVYASSFTPLMHNISGSKH 428 Query: 435 TDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAF 494 + M++I+ +S VLG H+LG A E++ + ++ GA D HPT +E Sbjct: 429 KEFMIRIITNESNGEVLGVHMLGDSAPEIIQSVGICMKMGAKISDFHSTIGVHPTSAEEL 488 Query: 495 REANLAASFGKS 506 A F +S Sbjct: 489 CSMRTPAYFYES 500 >1FEC-A nrPDB Length = 490 Score = 452 bits (1162), Expect = e-127, Method: Composition-based stats. Identities = 126/483 (26%), Positives = 209/483 (43%), Gaps = 27/483 (5%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNE---------TLGGTCLNVGCIPSKALL 92 D+ VIG+G GG A AA L K V + + LGGTC+NVGC+P K ++ Sbjct: 4 YDLVVIGAGSGGLEAGWNAASLHKKRVAVIDLQKHHGPPHYAALGGTCVNVGCVPKKLMV 63 Query: 93 NNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQ-NKVVHVN 151 ++Y ++ VR N ++ K+ AV + +F + Sbjct: 64 TGANYMDTIRESAGFGWELDRESVRPNWKALIAAKNKAVSGINDSYEGMFADTEGLTFHQ 123 Query: 152 GYGKITGKNQVTATKADGGT----QVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGAL 207 G+G + + V ++ + +DT+ IL+ATGS GI D D ++S A Sbjct: 124 GFGALQDNHTVLVRESADPNSAVLETLDTEYILLATGSWPQHL-GIEGD-DLCITSNEAF 181 Query: 208 SLKKVPEKMVVIGAGVIGVELGSVWQRL---GADVTAVEFLGHVGGVGIDMEISKNFQRI 264 L + P++ + +G G I +E ++ G V + G + G D E+ K Sbjct: 182 YLDEAPKRALCVGGGYISIEFAGIFNAYKARGGQVDL-AYRGDMILRGFDSELRKQLTEQ 240 Query: 265 LQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGL 324 L+ G + + TK +DG V E+ + DV+++ IGR P ++ L L Sbjct: 241 LRANGINVRTHENPAKVTKNADGTRHVVFESGA-----EADYDVVMLAIGRVPRSQTLQL 295 Query: 325 EELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVH- 383 E+ G+E+ G I V+ +T + NIYAIGDV ML A +EG V+ + Sbjct: 296 EKAGVEVAKNGAIKVDAYSKTNVDNIYAIGDVTDRVMLTPVAINEGAAFVDTVFANKPRA 355 Query: 384 IDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMV-KIL 442 D+ V +++ P + G EE ++ + V + F + + + +I+ Sbjct: 356 TDHTKVACAVFSIPPMGVCGYVEEDAAKKYDQVAVYESSFTPLMHNISGSTYKKFMVRIV 415 Query: 443 GQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAAS 502 + VLG H+LG + E++ A+ L+ GA D HPT +E A Sbjct: 416 TNHADGEVLGVHMLGDSSPEIIQSVAICLKMGAKISDFYNTIGVHPTSAEELCSMRTPAY 475 Query: 503 FGK 505 F + Sbjct: 476 FYE 478 >4NEW-A nrPDB Length = 492 Score = 451 bits (1160), Expect = e-127, Method: Composition-based stats. Identities = 127/489 (25%), Positives = 204/489 (41%), Gaps = 36/489 (7%) Query: 39 PIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNE---------TLGGTCLNVGCIPSK 89 P D+ VIG+G GG AA AA L K V + + LGGTC+NVGC+P K Sbjct: 3 PKIFDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGTCVNVGCVPKK 62 Query: 90 ALLNNSHYYHMAHGKDFASRGIEMSEVRL--NLDKMMEQKSTAVKALTGGIAHLFKQ-NK 146 ++ + Y H ++ A G E L ++ K AV + +F+ Sbjct: 63 LMVTGAQYME--HLRESAGFGWEFDRTTLRAEWKNLIAVKDEAVLNINKSYDEMFRDTEG 120 Query: 147 VVHVNGYGKITGKNQVTA----TKADGGTQVIDTKNILIATGSEV--TPFPGITIDEDTI 200 + G+G + KN V A + ++T++IL+A+GS PGI + Sbjct: 121 LEFFLGWGSLESKNVVNVRESADPASAVKERLETEHILLASGSWPHMPNIPGI----EHC 176 Query: 201 VSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGAD---VTAVEFLGHVGGVGIDMEI 257 +SS A L + P +++ +G G I VE ++ VT + G + G D + Sbjct: 177 ISSNEAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPKDGQVTLC-YRGEMILRGFDHTL 235 Query: 258 SKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRP 317 + + L G + +DG V+ E+ + D++++ IGR P Sbjct: 236 REELTKQLTANGIQILTKENPAKVELNADGSKSVTFESGK-----KMDFDLVMMAIGRSP 290 Query: 318 FTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGM 377 TK+L L+ G+ + G + V+ +T + NIYAIGDV ML A +E V+ + Sbjct: 291 RTKDLQLQNAGVMI-KNGGVQVDEYSRTNVSNIYAIGDVTNRVMLTPVAINEAAALVDTV 349 Query: 378 AGGAVH-IDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTD 436 G D+ V S +++ P + G EE + V F + + Sbjct: 350 FGTTPRKTDHTRVASAVFSIPPIGTCGLIEEVASKRYEVVAVYLSSFTPLMHKVSGSKYK 409 Query: 437 GMV-KILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFR 495 V KI+ S VLG H+LG A E++ + L+ A D HPT +E Sbjct: 410 TFVAKIITNHSDGTVLGVHLLGDNAPEIIQGIGICLKLNAKISDFYNTIGVHPTSAEELC 469 Query: 496 EANLAASFG 504 + + Sbjct: 470 SMRTPSYYY 478 >5W1J-A nrPDB Length = 584 Score = 450 bits (1159), Expect = e-127, Method: Composition-based stats. Identities = 135/496 (27%), Positives = 214/496 (43%), Gaps = 27/496 (5%) Query: 32 LRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET--------LGGTCLNV 83 ++ + D D+ +IG G GG A ++A+ G K ++ LGGTC+NV Sbjct: 94 VKKANEMKYDYDMVIIGGGSGGLALAKESAKSGAKVALLDFVVPTPMGTTWGLGGTCVNV 153 Query: 84 GCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFK 143 GCIP K + + H + +D S G ++ + + KM+E + AL G Sbjct: 154 GCIPKKLMHQAALLNH--YMEDAKSFGWDVDKGPHDWVKMVEGIQDHIHALNFGYRSSMM 211 Query: 144 QNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSS 203 V ++N G+I + + T G + I T I++ATG +P I ++ ++S Sbjct: 212 NANVKYLNALGEIVDPHTIKTTNKQGIVKNITTNTIIVATGERP-RYPPIPGAKEYGITS 270 Query: 204 TGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQR 263 +L P K + +GA + +E +G DVT + + + G D +++ Sbjct: 271 DDLFTLDHNPGKTLCVGASYVSLECAGFLSSIGCDVTVM--VRSIFLRGFDQQMAGLISD 328 Query: 264 ILQKQGFKFKLNTKVTGA----TKKSDGKIDVSIEA---ASGGKAEVITCDVLLVCIGRR 316 + K G KF T + E G T + +L +GR Sbjct: 329 YIAKYGVKFVRPCVPTSVRCLEEYDPESGKLAIYEVEGKHEDGTPFKDTFNTVLFAVGRD 388 Query: 317 PFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDV-VAGPMLAHKAEDEGIICVE 375 P T N+GL+ + ++ GR+ V+ +T +PNIYAIGDV AG L A G Sbjct: 389 PCTTNIGLQNVDVKTT-NGRVVVDDEERTNVPNIYAIGDVSNAGYQLTPLAIQAGKNLAR 447 Query: 376 GMA-GGAVHIDYNCVPSVIYTHPEVAWVGKSEE----QLKEEGIEYKVGKFPFAANSRAK 430 + DY VP+ ++T E +G SEE + E+ IE F + Sbjct: 448 RLYTADDCRTDYTNVPTTVFTPLEYGCIGLSEENAISKFGEDNIEVFHSYFQPLEWTVPH 507 Query: 431 TNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTL 490 +T I+ ++ +RV+G H+ GP AGE+ A+A+ GA ED R HPT Sbjct: 508 RPDNTCYAKLIINKQDDNRVVGFHVFGPNAGEVTQGYAVAMHLGARKEDFDRTIGIHPTC 567 Query: 491 SEAFREANLAASFGKS 506 SE F + S G S Sbjct: 568 SETFTTLRVTKSSGAS 583 >4B1B-A nrPDB Length = 542 Score = 448 bits (1153), Expect = e-126, Method: Composition-based stats. Identities = 136/501 (27%), Positives = 216/501 (43%), Gaps = 40/501 (7%) Query: 37 DQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET--------LGGTCLNVGCIPS 88 + D D VIG GPGG +A +AA G + + + + +GGTC+NVGC+P Sbjct: 38 EHTYDYDYVVIGGGPGGMASAKEAAAHGARVLLFDYVKPSSQGTKWGIGGTCVNVGCVPK 97 Query: 89 KALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVV 148 K + H D + G + ++ + K++ + +++L + +KV Sbjct: 98 KLMHYAGHM-GSIFKLDSKAYGWKFDNLKHDWKKLVTTVQSHIRSLNFSYMTGLRSSKVK 156 Query: 149 HVNGYGKITGKNQVTA--TKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGA 206 ++NG K+ KN V+ + + K ILIATG + ++ ++S Sbjct: 157 YINGLAKLKDKNTVSYYLKGDLSKEETVTGKYILIATGCRPHIPDDVEGAKELSITSDDI 216 Query: 207 LSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQ 266 SLKK P K +V+GA + +E LG DVT + + G D + + + ++ Sbjct: 217 FSLKKDPGKTLVVGASYVALECSGFLNSLGYDVTV--AVRSIVLRGFDQQCAVKVKLYME 274 Query: 267 KQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEE 326 +QG FK TK D KI V + D +L IGR+ L LE Sbjct: 275 EQGVMFKNGILPKKLTK-MDDKILVEFSDKTS-----ELYDTVLYAIGRKGDIDGLNLES 328 Query: 327 LGIELDP-RGRIPVNTRFQTKIPNIYAIGDVVAG-PMLAHKAEDEGIICVEGMAGGAVH- 383 L + ++ +I + T IP+I+A+GDV P LA A G I + + Sbjct: 329 LNMNVNKSNNKIIADHLSCTNIPSIFAVGDVAENVPELAPVAIKAGEILARRLFKDSDEI 388 Query: 384 IDYNCVPSVIYTHPEVAWVGKSEEQLKE----EGIEYKVGKF---PFAANSRAKTNADTD 436 +DY+ +P+ IYT E G SEE+ E +E + +F +A R K Sbjct: 389 MDYSYIPTSIYTPIEYGACGYSEEKAYELYGKSNVEVFLQEFNNLEISAVHRQKHIRAQK 448 Query: 437 ----------GMVKILGQK-STDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCH 485 + K++ K +RV+G H +GP AGE+ ALAL +D Sbjct: 449 DEYDLDVSSTCLAKLVCLKNEDNRVIGFHYVGPNAGEVTQGMALALRLKVKKKDFDNCIG 508 Query: 486 AHPTLSEAFREANLAASFGKS 506 HPT +E+F + S G S Sbjct: 509 IHPTDAESFMNLFVTISSGLS 529 >6CMZ-A nrPDB Length = 466 Score = 446 bits (1148), Expect = e-126, Method: Composition-based stats. Identities = 172/469 (36%), Positives = 255/469 (54%), Gaps = 14/469 (2%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMA 101 + VIG GPGGYVAAI+A QLG TV +E+ + LGGTCLN+GCIPSKAL++ + + A Sbjct: 9 TTLLVIGGGPGGYVAAIRAGQLGIPTVLVER-DRLGGTCLNIGCIPSKALIHVADAFEQA 67 Query: 102 HGKDFAS-RGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKN 160 G GI + +++ K + K V LT G+ L K++ V ++G ++ Sbjct: 68 CGHAGEGALGIRVRAPEIDIAKSVAWKDGIVDRLTRGVGALLKKSGVRVLHGEARVIDGK 127 Query: 161 QVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIG 220 V A G I +++L+ATGSE P + +VSST ALS +P+++VV+G Sbjct: 128 TVEVVSA-GHAVRIGCEHLLLATGSEPVELPSMPFGG-HVVSSTDALSPATLPKRLVVVG 185 Query: 221 AGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTG 280 AG IG+ELG V+++LG DV+ VE V D E+ + L + G + L KV G Sbjct: 186 AGYIGLELGIVYRKLGVDVSVVEAAERVLP-AYDAELVRPVADSLARLGVRLWLGHKVLG 244 Query: 281 ATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGR-IPV 339 K ++ A+ G + + D +LV +GRRP GLE + LD GR + + Sbjct: 245 LDKHGAVRVQ-----AADGAEQTLPADRVLVAVGRRPRVDGFGLET--LMLDRNGRALRI 297 Query: 340 NTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEV 399 + +T + N++AIGDV PMLAH+A +G + E +AG +P+V +T PE+ Sbjct: 298 DDTCRTSMRNVWAIGDVAGEPMLAHRAMAQGEMVAELIAGRRRQFMPAAIPAVCFTDPEI 357 Query: 400 AWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPG 459 G S + G++ FPFAAN RA T TDG V+++ ++ ++G +G G Sbjct: 358 VTAGWSPDDAHAAGVDCLSASFPFAANGRAMTLQATDGFVRVVARRDNHLIVGWQAVGRG 417 Query: 460 AGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSIN 508 E+ + +LE GA EDI HAHPTL EA +EA L A G +++ Sbjct: 418 VSELAAAFSQSLEMGARLEDIGGTIHAHPTLGEALQEAALRAL-GHALH 465 >1LVL-A nrPDB Length = 458 Score = 440 bits (1131), Expect = e-124, Method: Composition-based stats. Identities = 176/474 (37%), Positives = 267/474 (56%), Gaps = 17/474 (3%) Query: 37 DQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSH 96 Q I + +IG GPGGYVAAI+A QLG TV +E + LGGTCLN+GCIPSKAL++ + Sbjct: 1 QQTIQTTLLIIGGGPGGYVAAIRAGQLGIPTVLVE-GQALGGTCLNIGCIPSKALIHVAE 59 Query: 97 YYHMA-HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGK 155 +H A + + GI ++ RL++ + + K V LT G+A L K++ V V+G+ K Sbjct: 60 QFHQASRFTEPSPLGISVASPRLDIGQSVAWKDGIVDRLTTGVAALLKKHGVKVVHGWAK 119 Query: 156 ITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEK 215 + QV Q I +++L+ATGS P + + ++SST AL+ K +P+ Sbjct: 120 VLDGKQVEVD-----GQRIQCEHLLLATGSSSVELPMLPLGG-PVISSTEALAPKALPQH 173 Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 +VV+G G IG+ELG +++LGA V+ VE + D E++ L+K G L Sbjct: 174 LVVVGGGYIGLELGIAYRKLGAQVSVVEARERILPT-YDSELTAPVAESLKKLGIALHLG 232 Query: 276 TKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRG 335 V G +G + + GG+ + D +LV +GRRP TK LE L ++++ Sbjct: 233 HSVEGYE---NGCLLAN--DGKGGQLR-LEADRVLVAVGRRPRTKGFNLECLDLKMN-GA 285 Query: 336 RIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYT 395 I ++ R QT + N++AIGDV PMLAH+A +G + E +AG A + + +V +T Sbjct: 286 AIAIDERCQTSMHNVWAIGDVAGEPMLAHRAMAQGEMVAEIIAGKARRFEPAAIAAVCFT 345 Query: 396 HPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHI 455 PEV VGK+ EQ ++G++ V +FPFAAN RA + G V+++ ++ +LG Sbjct: 346 DPEVVVVGKTPEQASQQGLDCIVAQFPFAANGRAMSLESKSGFVRVVARRDNHLILGWQA 405 Query: 456 LGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF 509 +G E+ A +LE GA ED+A HAHPTL EA +EA L A G +++ Sbjct: 406 VGVAVSELSTAFAQSLEMGACLEDVAGTIHAHPTLGEAVQEAALRAL-GHALHI 458 >3O0H-A nrPDB Length = 484 Score = 440 bits (1131), Expect = e-124, Method: Composition-based stats. Identities = 108/468 (23%), Positives = 204/468 (43%), Gaps = 15/468 (3%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYH 99 D D+ VIGSG GG AA A LG + E+ +GGTC+ GC+P K S Y Sbjct: 25 FDFDLFVIGSGSGGVRAARLAGALGKRVAIAEEYR-IGGTCVIRGCVPKKLYFYASQYAQ 83 Query: 100 MAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGK 159 G + ++ N +K++ K+ + L G + + V + Sbjct: 84 E--FSKSIGFGWKYADPIFNWEKLVAAKNKEISRLEGLYREGLQNSNVHIYESRAVFVDE 141 Query: 160 NQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVI 219 + + + I + ILIATG+++ I D ++S L+K+P+ +V++ Sbjct: 142 HTLE---LSVTGERISAEKILIATGAKIVSNSAIKG-SDLCLTSNEIFDLEKLPKSIVIV 197 Query: 220 GAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVT 279 G G IGVE +++ LG T + G + D ++ + + +G V+ Sbjct: 198 GGGYIGVEFANIFHGLGVKTTLLH-RGDLILRNFDYDLRQLLNDAMVAKGISIIYEATVS 256 Query: 280 GATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPV 339 + ++ +V + + I D +++ GR P T LGLE G++++ G + V Sbjct: 257 QV-QSTENCYNVVLT-----NGQTICADRVMLATGRVPNTTGLGLERAGVKVNEFGAVVV 310 Query: 340 NTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMA-GGAVHIDYNCVPSVIYTHPE 398 + + T + +I+A+GDV L A + + V+ + DY+ + + +++ PE Sbjct: 311 DEKMTTNVSHIWAVGDVTGHIQLTPVAIHDAMCFVKNAFENTSTTPDYDLITTAVFSQPE 370 Query: 399 VAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGP 458 + VG SEE ++ + F + + +K++ + V+GAH+LG Sbjct: 371 IGTVGLSEEDALHRYKRVEIYRTVFRPMRNVLSGSPEKMFMKLVVDGESRIVVGAHVLGE 430 Query: 459 GAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKS 506 AGE+ ++L+ + + + HPT+SE + ++ Sbjct: 431 NAGEIAQLIGISLKGKLTKDIFDKTMAVHPTMSEELVTMYKPSYVYEN 478 >5X1Y-B nrPDB Length = 554 Score = 425 bits (1093), Expect = e-119, Method: Composition-based stats. Identities = 157/471 (33%), Positives = 241/471 (51%), Gaps = 20/471 (4%) Query: 41 DADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHM 100 + D+ +IGSG + +AIKA + G K IE+ T+GGTC+N+GC+PSK LL H+ Sbjct: 84 NYDLLIIGSGAAAFSSAIKAIEYGAKVGMIERG-TVGGTCVNIGCVPSKTLLRAGEIIHL 142 Query: 101 AHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKAL-TGGIAHLFKQNKVVHVNGYGKITGK 159 + F G++ S ++L ++ QK V L L + + G K Sbjct: 143 SKDNPFI--GLQTSAGEVDLASLITQKDKLVSELRNQKYMDLIDEYNFDLIKGEAKFVDA 200 Query: 160 NQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDED-TIVSSTGALSLKKVPEKMVV 218 + V A + K LIATG+ + P I+ E ++ST L LKK+P+++ V Sbjct: 201 STVEVNGAK-----LSAKRFLIATGASPS-LPQISGLEKMDYLTSTTLLELKKIPKRLTV 254 Query: 219 IGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKV 278 IG+G IG+ELG ++ LG+++T ++ D EIS++ ++ L +QG Sbjct: 255 IGSGYIGMELGQLFHHLGSEITLMQRSER-LLKEYDPEISESVEKALIEQGINLVKGATF 313 Query: 279 TGATKKSD-GKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRI 337 + + ++ V++ G EVI D LLV GR+P T +L L G+E I Sbjct: 314 ERVEQSGEIKRVYVTV----NGSREVIESDQLLVATGRKPNTDSLNLSAAGVETGKNNEI 369 Query: 338 PVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGG-AVHIDYNCVPSVIYTH 396 +N QT IYA GDV GP + A EG I + GG ID + VP+V +T+ Sbjct: 370 LINDFGQTSNEKIYAAGDVTLGPQFVYVAAYEGGIITDNAIGGLNKKIDLSVVPAVTFTN 429 Query: 397 PEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHIL 456 P VA VG +EEQ KE+G + K P A RA N +T G+ K++ T +VLG HI+ Sbjct: 430 PTVATVGLTEEQAKEKGYDVKTSVLPLDAVPRAIVNRETTGVFKLVADAETLKVLGVHIV 489 Query: 457 GPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSI 507 AG+++ A+LA+++G + ED+ + T++E + A L F K I Sbjct: 490 SENAGDVIYAASLAVKFGLTVEDLTETLAPYLTMAEGLKLAALT--FDKDI 538 >3II4-A nrPDB Length = 466 Score = 425 bits (1093), Expect = e-119, Method: Composition-based stats. Identities = 168/470 (35%), Positives = 247/470 (52%), Gaps = 11/470 (2%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMA 101 DV V+G+GPGGYVAAI+AAQLG T +E + GG CLNVGCIPSKALL N+ H Sbjct: 6 YDVVVLGAGPGGYVAAIRAAQLGLSTAIVEP-KYWGGVCLNVGCIPSKALLRNAELVH-I 63 Query: 102 HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQ 161 KD + GI EV + ++ + G+ L K+NK+ ++GYG N Sbjct: 64 FTKDAKAFGIS-GEVTFDYGIAYDRSRKVAEGRVAGVHFLMKKNKITEIHGYGTFADANT 122 Query: 162 VTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGA 221 + DGGT+ + N +IATGS PG ++ + + LS +++P+ +++ GA Sbjct: 123 LLVDLNDGGTESVTFDNAIIATGSSTRLVPGTSLSANVVTYEEQILS-RELPKSIIIAGA 181 Query: 222 GVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGA 281 G IG+E G V + G DVT VEFL D ++SK ++ +K G TKV Sbjct: 182 GAIGMEFGYVLKNYGVDVTIVEFLPRALP-NEDADVSKEIEKQFKKLGVTILTATKVESI 240 Query: 282 TKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNT 341 +DG V++ G A+ + + +L IG P + GL++ G+ L R I V+ Sbjct: 241 ---ADGGSQVTVTVTKDGVAQELKAEKVLQAIGFAPNVEGYGLDKAGVALTDRKAIGVDD 297 Query: 342 RFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHI--DYNCVPSVIYTHPEV 399 +T + +IYAIGDV LAH AE +G++ E +AG D+ +P + P V Sbjct: 298 YMRTNVGHIYAIGDVNGLLQLAHVAEAQGVVAAETIAGAETLTLGDHRMLPRATFCQPNV 357 Query: 400 AWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPG 459 A G +E+Q + EG + V KFPF AN++A D G VK++ +LG H++G Sbjct: 358 ASFGLTEQQARNEGYDVVVAKFPFTANAKAHGVGDPSGFVKLVADAKHGELLGGHLVGHD 417 Query: 460 AGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSINF 509 E++ E LA + + ++AR H HPT+SEA +E G INF Sbjct: 418 VAELLPELTLAQRWDLTASELARNVHTHPTMSEALQEC-FHGLVGHMINF 466 >4DNA-A nrPDB Length = 463 Score = 420 bits (1081), Expect = e-118, Method: Composition-based stats. Identities = 117/464 (25%), Positives = 203/464 (43%), Gaps = 14/464 (3%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYH 99 D D+ VIG G GG + AA LG K E+ GGTC+ GC+P K + S + Sbjct: 4 FDYDLFVIGGGSGGVRSGRLAAALGKKVAIAEE-FRYGGTCVIRGCVPKKLYVYASQFAE 62 Query: 100 MAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGK 159 H +D A G + E R + K++ K + L G ++ ++ G Sbjct: 63 --HFEDAAGFGWTVGESRFDWAKLVAAKEQEIARLEGLYRKGLANAGAEILDTRAELAGP 120 Query: 160 NQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVI 219 N V K + + + I+IA G +P + + ++S A L +PE +++ Sbjct: 121 NTV---KLLASGKTVTAERIVIAVGGHPSPHDALPG-HELCITSNEAFDLPALPESILIA 176 Query: 220 GAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVT 279 G G I VE +++ LG T + + D ++ + ++++G + + Sbjct: 177 GGGYIAVEFANIFHGLGVKTTLIYRGKEILSR-FDQDMRRGLHAAMEEKGIRILCEDIIQ 235 Query: 280 GATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPV 339 + +DG+ A+ K I D +++ +GR P T LGLE G+ + G I V Sbjct: 236 SVSADADGR-----RVATTMKHGEIVADQVMLALGRMPNTNGLGLEAAGVRTNELGAIIV 290 Query: 340 NTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEG-MAGGAVHIDYNCVPSVIYTHPE 398 + +T P IYA+GDV L A E + +E D++ + + +++ PE Sbjct: 291 DAFSRTSTPGIYALGDVTDRVQLTPVAIHEAMCFIETEYKNNPTSPDHDLIATAVFSQPE 350 Query: 399 VAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGP 458 + VG +EE+ + E +V + F + ++K++ + +V+GAHILG Sbjct: 351 IGTVGITEEEAARKFQEIEVYRAEFRPMKATLSGRKEKTIMKLVVNAADRKVVGAHILGH 410 Query: 459 GAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAAS 502 AGEM ++L G + +D R HPT +E + Sbjct: 411 DAGEMAQLLGISLRAGCTKDDFDRTMAVHPTAAEELVTMYQPSY 454 >1ONF-A nrPDB Length = 500 Score = 400 bits (1027), Expect = e-111, Method: Composition-based stats. Identities = 124/506 (24%), Positives = 216/506 (42%), Gaps = 63/506 (12%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMA 101 D+ VIG G GG AA +AA+ K +EK+ LGGTC+NVGC+P K + N + + + Sbjct: 3 YDLIVIGGGSGGMAAARRAARHNAKVALVEKSR-LGGTCVNVGCVPKKIMFNAASVHDIL 61 Query: 102 HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQ 161 + S NL ++E++ ++ L ++KV G +N+ Sbjct: 62 ENSRHYGFDTKFS---FNLPLLVERRDKYIQRLNNIYRQNLSKDKVDLYEGTASFLSENR 118 Query: 162 VTATKADG---------GTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKV 212 + ++++ +NILIA G++ FP + E+TI SS ++K+ Sbjct: 119 ILIKGTKDNNNKDNGPLNEEILEGRNILIAVGNKPV-FPPVKGIENTI-SSDEFFNIKE- 175 Query: 213 PEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKF 272 +K+ ++G+G I VEL +V +RLG D + + G+ D + + ++K Sbjct: 176 SKKIGIVGSGYIAVELINVIKRLGID-SYIFARGNRILRKFDESVINVLENDMKKNNINI 234 Query: 273 KLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELD 332 V K SD + + + + D ++ C+GR P T+NL LE+L +E + Sbjct: 235 VTFADVVEIKKVSDKNLSIHLSDGRIYE----HFDHVIYCVGRSPDTENLKLEKLNVETN 290 Query: 333 PRGRIPVNTRFQTKIPNIYAIGDVV----------------------------------A 358 I V+ +T + NIYA+GD Sbjct: 291 -NNYIVVDENQRTSVNNIYAVGDCCMVKKSKEIEDLNLLKLYNEERYLNKKENVTEDIFY 349 Query: 359 GPMLAHKAEDEGIICVEGMAGGAVH-IDYNCVPSVIYTHPEVAWVGKSEEQL----KEEG 413 L A + G + + + +Y +P+VI++HP + +G SEE +E Sbjct: 350 NVQLTPVAINAGRLLADRLFLKKTRKTNYKLIPTVIFSHPPIGTIGLSEEAAIQIYGKEN 409 Query: 414 IEYKVGKFP--FAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALAL 471 ++ KF F + + +K++ + + G HI+G A E+V A+AL Sbjct: 410 VKIYESKFTNLFFSVYDIEPELKEKTYLKLVCVGKDELIKGLHIIGLNADEIVQGFAVAL 469 Query: 472 EYGASCEDIARVCHAHPTLSEAFREA 497 + A+ +D HPT +E F Sbjct: 470 KMNATKKDFDETIPIHPTAAEEFLTL 495 >1OJT-A nrPDB Length = 482 Score = 388 bits (996), Expect = e-108, Method: Composition-based stats. Identities = 171/455 (37%), Positives = 248/455 (54%), Gaps = 16/455 (3%) Query: 54 YVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEM 113 Y AA AA G K +E+ +TLGG CLNVGCIPSKALL+N+ + A+ GI+ Sbjct: 19 YSAAFAAADEGLKVAIVERYKTLGGVCLNVGCIPSKALLHNAAVIDEV--RHLAANGIKY 76 Query: 114 SEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKA------ 167 E L++D + K V LTGG+A + K KV + G G+ + + + Sbjct: 77 PEPELDIDMLRAYKDGVVSRLTGGLAGMAKSRKVDVIQGDGQFLDPHHLEVSLTAGDAYE 136 Query: 168 ----DGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGV 223 G +++ KN +IA GS VT P I D I+ S+GAL+LK+VP K+++IG G+ Sbjct: 137 QAAPTGEKKIVAFKNCIIAAGSRVTKLPFIPEDP-RIIDSSGALALKEVPGKLLIIGGGI 195 Query: 224 IGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATK 283 IG+E+G+V+ LG+ + VE + + G D ++ K +Q+ + + +NTK Sbjct: 196 IGLEMGTVYSTLGSRLDVVEMMDGLM-QGADRDLVKVWQKQNEYRFDNIMVNTKTVAVEP 254 Query: 284 KSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRF 343 K DG + V+ E A+ K E D +LV GR P K + E+ G+ + RG I V+ + Sbjct: 255 KEDG-VYVTFEGANAPK-EPQRYDAVLVAAGRAPNGKLISAEKAGVAVTDRGFIEVDKQM 312 Query: 344 QTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVG 403 +T +P+IYAIGD+V PMLAHKA EG + E AG + D +P V YT PEVAWVG Sbjct: 313 RTNVPHIYAIGDIVGQPMLAHKAVHEGHVAAENCAGHKAYFDARVIPGVAYTSPEVAWVG 372 Query: 404 KSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEM 463 ++E K + FP+AA+ RA N K++ T R++G I+GP G+M Sbjct: 373 ETELSAKASARKITKANFPWAASGRAIANGCDKPFTKLIFDAETGRIIGGGIVGPNGGDM 432 Query: 464 VNEAALALEYGASCEDIARVCHAHPTLSEAFREAN 498 + E LA+E G DI + H HPTL E+ A Sbjct: 433 IGEVCLAIEMGCDAADIGKTIHPHPTLGESIGMAA 467 >5U25-A nrPDB Length = 602 Score = 385 bits (990), Expect = e-107, Method: Composition-based stats. Identities = 173/455 (38%), Positives = 251/455 (55%), Gaps = 16/455 (3%) Query: 54 YVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEM 113 Y AA AA G K +E+ +TLGG CLNVGCIPSKALL+N+ + A+ GI+ Sbjct: 138 YSAAFAAADEGLKVAIVERYKTLGGVCLNVGCIPSKALLHNAAVIDEV--RHLAANGIKY 195 Query: 114 SEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKA------ 167 E L++D + K V LTGG+A + K KV + G G+ + + + Sbjct: 196 PEPELDIDMLRAYKDGVVSRLTGGLAGMAKSRKVDVIQGDGQFLDPHHLEVSLTAGDAYE 255 Query: 168 ----DGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGV 223 G +++ KN +IA GS VT P I D I+ S+GAL+LK+VP K+++IG G+ Sbjct: 256 QAAPTGEKKIVAFKNCIIAAGSRVTKLPFIPEDP-RIIDSSGALALKEVPGKLLIIGGGI 314 Query: 224 IGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATK 283 IG+E+G+V+ LG+ + VE + + G D ++ K +Q+ + + +NTK Sbjct: 315 IGLEMGTVYSTLGSRLDVVEMMDGLM-QGADRDLVKVWQKQNEYRFDNIMVNTKTVAVEP 373 Query: 284 KSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRF 343 K DG + V+ E A+ K E D +LV GR P K + E+ G+ + RG I V+ + Sbjct: 374 KEDG-VYVTFEGANAPK-EPQRYDAVLVAAGRAPNGKLISAEKAGVAVTDRGFIEVDKQM 431 Query: 344 QTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVG 403 +T +P+IYAIGD+V PMLAHKA EG + E AG + D +P V YT PEVAWVG Sbjct: 432 RTNVPHIYAIGDIVGQPMLAHKAVHEGHVAAENCAGHKAYFDARVIPGVAYTSPEVAWVG 491 Query: 404 KSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEM 463 ++E K G + FP+AA+ RA N +G K++ T R++G I+GP G+M Sbjct: 492 ETELSAKASGRKITKANFPWAASGRAIANGCDNGFTKLIFDAETGRIIGGGIVGPNGGDM 551 Query: 464 VNEAALALEYGASCEDIARVCHAHPTLSEAFREAN 498 + E LA+E G DI + H HPTL E+ A Sbjct: 552 IGEVCLAIEMGCDAADIGKTIHPHPTLGESIGMAA 586 >4YWO-A nrPDB Length = 462 Score = 384 bits (987), Expect = e-107, Method: Composition-based stats. Identities = 139/466 (29%), Positives = 217/466 (46%), Gaps = 30/466 (6%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHG 103 + +IG G G+ A IKA +LG K V I K E +GGTC+NVGC+PSK +L + Y A Sbjct: 18 LAIIGYGAAGFAAMIKANELGVKPVLIGKGE-IGGTCVNVGCVPSKRMLYIAEIYKKARE 76 Query: 104 KDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVT 163 + SEV E+ + L V + G + + V Sbjct: 77 -------VTGSEVYPPFSSFQEKDGLVQEMRKTKYEDLLSYYDVELIQGEARFISPHAVK 129 Query: 164 ATKADGGTQVIDTKNILIATGSEV--TPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGA 221 QVI+ + +IATGS PG +D+ ++ ALS + + + VIG Sbjct: 130 V-----NGQVIEAEKFVIATGSSPLIPRIPG--LDKVGFWTNREALSPDRRIDSLAVIGG 182 Query: 222 GVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGA 281 + +E ++ R+ +V ++ V + E S +RI++ G V Sbjct: 183 RALALEFAQMYSRMKVEVAILQRSP-VLIPDWEPEASVEARRIMENDGVAVVTGVNVKEV 241 Query: 282 TKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNT 341 +K GKI ++ + D +L+ GR+P LGLE G+ L+ RG I V+ Sbjct: 242 -RKGAGKIVIT-------DKGEVEADEILLATGRKPNVD-LGLENAGVRLNERGGIKVDD 292 Query: 342 RFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEG-MAGGAVHIDYNCVPSVIYTHPEVA 400 +T P+IYA GDV+ G ML A +G I E + G +D N VP VI+T P +A Sbjct: 293 ELRTDNPHIYAAGDVLGGKMLEALAGRQGSIATENALTGSHKRVDENAVPQVIFTQPNLA 352 Query: 401 WVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGA 460 VG +E + + + E + P ++ ++A+ G VK++ R++G H +G Sbjct: 353 RVGLTEAEARAKEGEVEARVLPMSSVAKAEIINSRLGFVKMVTM--NGRIVGVHAVGENV 410 Query: 461 GEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKS 506 EM+ EAALA+ +GA+ D+ H PT++E+ R LA S Sbjct: 411 AEMIGEAALAIRFGATVHDLIDTVHMFPTIAESLRLVALAFRSDVS 456 >1ZK7-A nrPDB Length = 467 Score = 375 bits (962), Expect = e-104, Method: Composition-based stats. Identities = 137/471 (29%), Positives = 225/471 (47%), Gaps = 19/471 (4%) Query: 41 DADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHM 100 V VIGSG AA+KA + G + IE+ T+GGTC+NVGC+PSK ++ +H H+ Sbjct: 4 PVQVAVIGSGGAAMAAALKAVEQGAQVTLIERG-TIGGTCVNVGCVPSKIMIRAAHIAHL 62 Query: 101 AHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKAL-TGGIAHLFKQN-KVVHVNGYGKITG 158 F GI + ++ K++ Q+ V L + N + V+G + Sbjct: 63 RRESPFDG-GIAATVPTIDRSKLLAQQQARVDELRHAKYEGILGGNPAITVVHGEARFKD 121 Query: 159 KNQVTATKADGGTQVIDTKNILIATGSEV--TPFPGITIDEDTIVSSTGALSLKKVPEKM 216 +T +GG +V+ L+ATG+ P PG+ E +ST AL+ +PE++ Sbjct: 122 DQSLTVRLNEGGERVVMFDRCLVATGASPAVPPIPGLK--ESPYWTSTEALASDTIPERL 179 Query: 217 VVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNT 276 VIG+ V+ +EL + RLG+ VT + + D I + + +G + L Sbjct: 180 AVIGSSVVALELAQAFARLGSKVTVL--ARNTLFFREDPAIGEAVTAAFRAEGIEV-LEH 236 Query: 277 KVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGR 336 DG+ ++ + D LLV GR P T++L L+ G+ ++ +G Sbjct: 237 TQASQVAHMDGEFVLTTTHG------ELRADKLLVATGRTPNTRSLALDAAGVTVNAQGA 290 Query: 337 IPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTH 396 I ++ +T PNIYA GD P + A G M GG +D +P+V++T Sbjct: 291 IVIDQGMRTSNPNIYAAGDCTDQPQFVYVAAAAGTRAAINMTGGDAALDLTAMPAVVFTD 350 Query: 397 PEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHIL 456 P+VA VG SE + +GIE RA N DT G +K++ ++ + R++G + Sbjct: 351 PQVATVGYSEAEAHHDGIETDSRTLTLDNVPRALANFDTRGFIKLVIEEGSHRLIGVQAV 410 Query: 457 GPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSI 507 P AGE++ AALA+ + +++A + T+ E + A A +F K + Sbjct: 411 APEAGELIQTAALAIRNRMTVQELADQLFPYLTMVEGLKLA--AQTFNKDV 459 >1XDI-A nrPDB Length = 499 Score = 332 bits (852), Expect = 2e-91, Method: Composition-based stats. Identities = 117/474 (24%), Positives = 207/474 (43%), Gaps = 16/474 (3%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKT--VCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMA 101 + ++G GP GY AA+ AA +T V + + +GG + C+PSK + ++ Sbjct: 5 IVILGGGPAGYEAALVAATSHPETTQVTVIDCDGIGGAAVLDDCVPSKTFIASTGLRTEL 64 Query: 102 HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGK-- 159 I+ + +++L ++ + T A + I V + G G++ Sbjct: 65 RRAPHLGFHIDFDDAKISLPQIHARVKTLAAAQSADITAQLLSMGVQVIAGRGELIDSTP 124 Query: 160 ----NQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEK 215 +++ AT ADG T + +L+ATG+ P D + I++ L +P+ Sbjct: 125 GLARHRIKATAADGSTSEHEADVVLVATGASPRILPSAQPDGERILTWRQLYDLDALPDH 184 Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 ++V+G+GV G E + LG VT V HV D + + + ++G + N Sbjct: 185 LIVVGSGVTGAEFVDAYTELGVPVTVVASQDHVLP-YEDADAALVLEESFAERGVRLFKN 243 Query: 276 TKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRG 335 + T+ G V + G + L+ IG P T LGLE +GI+L Sbjct: 244 ARAASVTRTGAG---VLVTMTDG---RTVEGSHALMTIGSVPNTSGLGLERVGIQLGRGN 297 Query: 336 RIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICV-EGMAGGAVHIDYNCVPSVIY 394 + V+ +T IYA GD LA A +G I + + G I V + ++ Sbjct: 298 YLTVDRVSRTLATGIYAAGDCTGLLPLASVAAMQGRIAMYHALGEGVSPIRLRTVAATVF 357 Query: 395 THPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAH 454 T PE+A VG + + + + P N+RAK + G VKI ++ST V+G Sbjct: 358 TRPEIAAVGVPQSVIDAGSVAARTIMLPLRTNARAKMSEMRHGFVKIFCRRSTGVVIGGV 417 Query: 455 ILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREANLAASFGKSIN 508 ++ P A E++ A+A++ + ++A+ +P+LS + EA ++ Sbjct: 418 VVAPIASELILPIAVAVQNRITVNELAQTLAVYPSLSGSITEAARRLMAHDDLD 471 >3IC9-A nrPDB Length = 492 Score = 317 bits (812), Expect = 8e-87, Method: Composition-based stats. Identities = 120/471 (25%), Positives = 203/471 (43%), Gaps = 20/471 (4%) Query: 36 ADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNS 95 A + I+ DV +IG+G G A +AA+ V + + G TC VGC+PSK L+ + Sbjct: 3 AMKVINVDVAIIGTGTAGM-GAYRAAKKHTDKVVLIEGGAYGTTCARVGCMPSKLLIAAA 61 Query: 96 HYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQ-NKVVHVNGYG 154 + H GI++ + +N +M++ T G + + ++ + G+ Sbjct: 62 DASY--HASQTDLFGIQVDRISVNGKAVMKRIQTERDRFVGFVVESVESFDEQDKIRGFA 119 Query: 155 KITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPE 214 K ++ + D +QVI K I+IATGS + ++++ L +P+ Sbjct: 120 KFLDEHTLQV---DDHSQVI-AKRIVIATGSRPNYPEFLAAAGSRLLTNDNLFELNDLPK 175 Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL 274 + V G GVIG+ELG RLG V G V D E+ + ++ ++ F F Sbjct: 176 SVAVFGPGVIGLELGQALSRLGVIVKVFGRSGSV-ANLQDEEMKRYAEKTFNEE-FYFDA 233 Query: 275 NTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPR 334 +V +K D ++V SG K + +L GR+ LGLE IELD + Sbjct: 234 KARVISTIEKED-AVEVIYFDKSGQKT-TESFQYVLAATGRKANVDKLGLENTSIELDKK 291 Query: 335 GRIPVNT-RFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGA--VHIDYNCVPS 391 + QT + +I+ GD L H+A D+G + S Sbjct: 292 NSPLFDELTLQTSVDHIFVAGDANNTLTLLHEAADDGKVAGTNAGAYPVIAQGQRRAPLS 351 Query: 392 VIYTHPEVAWVGKSEEQ-----LKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKS 446 V++T P+VA VG S Q ++ Y VG+ F R++ G++ + ++ Sbjct: 352 VVFTEPQVASVGLSLRQIEDLYADQDAANYVVGQVSFEGQGRSRVMGKNKGLLNVYADRT 411 Query: 447 TDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREA 497 + LGA + GP A + + A A + + + + + HP + E R A Sbjct: 412 SGEFLGAEMFGPAAEHIGHLLAWARQQQMTVQAMLTMPFYHPVIEEGLRTA 462 >3L8K-A nrPDB Length = 466 Score = 316 bits (810), Expect = 1e-86, Method: Composition-based stats. Identities = 120/467 (25%), Positives = 215/467 (46%), Gaps = 31/467 (6%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYH 99 + DV VIG+G GY A + A+ + + + LGG CL GC+PSK + Sbjct: 3 LKYDVVVIGAGGAGYHGAFRLAKAKYNVLMADPKGELGGNCLYSGCVPSKTVREVIQ--- 59 Query: 100 MAHGKDFASRGIEMSEVRLNLD-KMMEQKSTAVKALTGG--IAHLFKQNKVVHVNGYGKI 156 A R ++ V++ LD ++ + V+ L ++ + + GY KI Sbjct: 60 ------TAWRLTNIANVKIPLDFSTVQDRKDYVQELRFKQHKRNMSQYETLTFYKGYVKI 113 Query: 157 TGKNQVTATKADGGTQVIDTKNILIATGSEV--TPFPGITIDEDTIVSSTGAL----SLK 210 V +G +T+ ++IA+G+E PG+ + ++S S + Sbjct: 114 KDPTHVIVKTDEGKEIEAETRYMIIASGAETAKLRLPGV----EYCLTSDDIFGYKTSFR 169 Query: 211 KVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGF 270 K+P+ MV+IGAG IG+E+ S+++ +G +E L D +I IL+ Sbjct: 170 KLPQDMVIIGAGYIGLEIASIFRLMGVQTHIIEMLDRALITLEDQDIVNTLLSILK---L 226 Query: 271 KFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIE 330 K N+ VT K D + +V G K + T + +++ GRRP G E+G+ Sbjct: 227 NIKFNSPVTEVKKIKDDEYEVIYSTKDGSKKSIFT-NSVVLAAGRRPVIPE-GAREIGLS 284 Query: 331 LDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDY---N 387 + G I V+ +T IPN++A GD H A I + + +DY Sbjct: 285 ISKTG-IVVDETMKTNIPNVFATGDANGLAPYYHAAVRMSIAAANNIMANGMPVDYVDVK 343 Query: 388 CVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKST 447 +P IYT P +++VG + ++ GIE ++ + A+ +G++K++ ++ + Sbjct: 344 SIPVTIYTIPSLSYVGILPSKARKMGIEIVEAEYNMEEDVSAQIYGQKEGVLKLIFERGS 403 Query: 448 DRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAF 494 R++GA ++G + ++NE LA+ YG + + +A HP+ +E Sbjct: 404 MRLIGAWMIGVHSQYLINELGLAVAYGLNAKQLASFAEQHPSTNEII 450 >3Q6J-A nrPDB Length = 523 Score = 315 bits (807), Expect = 3e-86, Method: Composition-based stats. Identities = 106/476 (22%), Positives = 197/476 (41%), Gaps = 32/476 (6%) Query: 37 DQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSH 96 + P + D IG G G + +G + + +++ LGG+C + C+P + + Sbjct: 39 NDPREYDAIFIGGGAAGRFGSAYLRAMGGRQLIVDRWPFLGGSCPHNACVPHHLFSDCAA 98 Query: 97 YYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQ--NKVVHVNGYG 154 +A +M+E + + ++++ G + K+ N +N Sbjct: 99 ELMLARTFSGQYWFPDMTEKVVGIKEVVDLFRAGRNGPHGIMNFQSKEQLNLEYILNCPA 158 Query: 155 KITGKNQVTATKADGGTQVIDTKNILIATGSEV--TPFPGITIDEDTIVSSTGALSLKKV 212 K+ + V A +V KN+++A G+ PG+ + +T L Sbjct: 159 KVIDNHTVEAA-----GKVFKAKNLILAVGAGPGTLDVPGVN-AKGVFDHATLVEELDYE 212 Query: 213 PEK-MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFK 271 P +VV+G VE G + G T + + D E +++QG + Sbjct: 213 PGSTVVVVGGSKTAVEYGCFFNATGRR-TVMLVRTEPLKLIKDNETRAYVLDRMKEQGME 271 Query: 272 FKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIEL 331 + VT + ++G++ + G+ I D + + +G +P + L + LG++L Sbjct: 272 IISGSNVTRIEEDANGRVQAVVAMTPNGEMR-IETDFVFLGLGEQPRSAEL-AKILGLDL 329 Query: 332 DPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPS 391 P+G + VN QT +PN+YA+GD++ GPM KA G + G + P Sbjct: 330 GPKGEVLVNEYLQTSVPNVYAVGDLIGGPMEMFKARKSGCYAARNVMGEKISYTPKNYPD 389 Query: 392 VIYTHPEVAWVGKSEEQLKEEGIEYKVGKFP----------FAANSRAK------TNADT 435 ++TH EV+++G EE+ + G E K P A+ R A Sbjct: 390 FLHTHYEVSFLGMGEEEARAAGHEIVTIKMPPDTENGLNVALPASDRTMLYAFGKGTAHM 449 Query: 436 DGMVKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARV--CHAHPT 489 G KI+ T +VLGAH +G GA + + ++ G + +++ + +PT Sbjct: 450 SGFQKIVIDAKTRKVLGAHHVGYGAKDAFQYLNVLIKQGLTVDELGDMDELFLNPT 505 >2BC1-A nrPDB Length = 490 Score = 220 bits (562), Expect = 8e-58, Method: Composition-based stats. Identities = 84/381 (22%), Positives = 147/381 (38%), Gaps = 43/381 (11%) Query: 158 GKNQVTATKADGGTQVIDTKNILIATGSEV--TPFPGITIDEDTIVSSTGALSLKKVP-- 213 VTA DG V ++ ATGS+ P G I E ++ +L+ V Sbjct: 121 DAKTVTA-LVDGKNHVETYDKLIFATGSQPILPPIKGAEIKEGSLEFEATLENLQFVKLY 179 Query: 214 ---------------EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEIS 258 +++ V+GAG IGVEL +QR G +V ++ + D +++ Sbjct: 180 QNSADVIAKLENKDIKRVAVVGAGYIGVELAEAFQRKGKEVVLIDVVDTCLAGYYDRDLT 239 Query: 259 KNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPF 318 + +++ G + V +GK++ I + D++++ +G RP Sbjct: 240 DLMAKNMEEHGIQLAFGETVKEVA--GNGKVEKIITDKN-----EYDVDMVILAVGFRPN 292 Query: 319 TKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDV----------VAGPMLAHKAED 368 T L I+L G VN R +T IP +YAIGD LA A Sbjct: 293 TT---LGNGKIDLFRNGAFLVNKRQETSIPGVYAIGDCATIYDNATRDTNYIALASNAVR 349 Query: 369 EGIICVEGMAGGAVH-IDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANS 427 GI+ G + I + + G + E+ K G + V ++ Sbjct: 350 TGIVAAHNACGTDLEGIGVQGSNGISIYGLHMVSTGLTLEKAKRLGFDAAVTEYTDNQKP 409 Query: 428 RAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEM-VNEAALALEYGASCEDIARV-CH 485 + + +KI+ K + R+LGA + M ++ +LA++ G + E +A Sbjct: 410 EFIEHGNFPVTIKIVYDKDSRRILGAQMAAREDVSMGIHMFSLAIQEGVTIEKLALTDIF 469 Query: 486 AHPTLSEAFREANLAASFGKS 506 P ++ + +AA K Sbjct: 470 FLPHFNKPYNYITMAALGAKD 490 >3ICS-A nrPDB Length = 588 Score = 214 bits (545), Expect = 8e-56, Method: Composition-based stats. Identities = 92/412 (22%), Positives = 158/412 (38%), Gaps = 46/412 (11%) Query: 121 DKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNIL 180 +++ K I L ++VV +N K VT + T ++ Sbjct: 93 KLLVQTVERMSKRFNLDIRVL---SEVVKINKEEKTITIKNVTTNE----TYNEAYDVLI 145 Query: 181 IATGSEV--TPFPGITIDEDTIV-------SSTGALSLKKVPEKMVVIGAGVIGVELGSV 231 ++ G++ PGI + A +K P VIG G IGVE+ Sbjct: 146 LSPGAKPIVPSIPGIEEAKALFTLRNVPDTDRIKAYIDEKKPRHATVIGGGFIGVEMVEN 205 Query: 232 WQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDV 291 + G +VT VE V ID E++ ++ + V + Sbjct: 206 LRERGIEVTLVEMANQVMPP-IDYEMAAYVHEHMKNHDVELVFEDGVDALEENGA----- 259 Query: 292 SIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIY 351 VI D+L++ IG +P + + G+ L RG I VN +FQT P+IY Sbjct: 260 ---VVRLKSGSVIQTDMLILAIGVQPESSL--AKGAGLALGVRGTIKVNEKFQTSDPHIY 314 Query: 352 AIGDVVA----------GPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSV----IYTHP 397 AIGD + LA A +G + + + G + Y ++ Sbjct: 315 AIGDAIEVKDFVTETETMIPLAWPANRQGRMLADIIHGHTDSL-YKGTLGTSVAKVF-DL 372 Query: 398 EVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILG 457 VA G +E+ LK I Y+V +++ NA T ++K++ K + ++ GA LG Sbjct: 373 TVATTGLNEKILKRLNIPYEVVHVQANSHAGYYPNA-TPVLIKLIFNKDSGKIYGAQTLG 431 Query: 458 -PGAGEMVNEAALALEYGASCEDIARVCHAH-PTLSEAFREANLAASFGKSI 507 G + ++ A A++ + D+ + ++ P S A N+ +I Sbjct: 432 RDGVDKRMDVIATAIKANLTVLDLPDLELSYAPPYSSAKDPVNMVGYAASNI 483 >3NTA-A nrPDB Length = 574 Score = 208 bits (529), Expect = 6e-54, Method: Composition-based stats. Identities = 83/379 (21%), Positives = 145/379 (38%), Gaps = 46/379 (12%) Query: 167 ADGGTQVIDTKNILIATGSEV--TPFPGIT----------IDEDTIVSSTGALSLKKVPE 214 DG +L++ G+ P PG+ D D I+ + ++ E Sbjct: 97 LDGSEYQESYDTLLLSPGAAPIVPPIPGVDNPLTHSLRNIPDMDRILQTIQMNNV----E 152 Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL 274 V+G G IG+E+ LG T +E V +D E++ + ++ QG +L Sbjct: 153 HATVVGGGFIGLEMMESLHHLGIKTTLLELADQVM-TPVDREMAGFAHQAIRDQGVDLRL 211 Query: 275 NTKVTGATKKSDGKIDVSIEAASG-------------GKAEVITCDVLLVCIGRRPFTKN 321 T ++ + + + E++ D+L++ IG RP T+ Sbjct: 212 GTALSEVSYQVQTHVASDAAGEDTAHQHIKGHLSLTLSNGELLETDLLIMAIGVRPETQL 271 Query: 322 LGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAG----------PMLAHKAEDEGI 371 + G+ + G I VN QT P IYA+GD V LA A +G Sbjct: 272 --ARDAGLAIGELGGIKVNAMMQTSDPAIYAVGDAVEEQDFVTGQACLVPLAGPANRQGR 329 Query: 372 ICVEGMAGGAVHIDYNCVPSVIYT-HPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAK 430 + + M G ++ V GK+E+QLK+ GI ++ A+++ Sbjct: 330 MAADNMFGREERYQGTQGTAICKVFDLAVGATGKNEKQLKQAGIAFEKVYVHTASHASYY 389 Query: 431 TNADTDGMVKILGQKSTDRVLGAHILG-PGAGEMVNEAALALEYGASCEDIARVCHAH-P 488 A+ K+L + GA +G G + ++ A+A G + E + + ++ P Sbjct: 390 PGAEVVSF-KLLFDPVKGTIFGAQAVGKDGIDKRIDVMAVAQRAGMTVEQLQHLELSYAP 448 Query: 489 TLSEAFREANLAASFGKSI 507 A N AA +I Sbjct: 449 PYGSAKDVINQAAFVASNI 467 >3CGD-A nrPDB Length = 480 Score = 200 bits (509), Expect = 1e-51, Method: Composition-based stats. Identities = 95/482 (19%), Positives = 163/482 (33%), Gaps = 66/482 (13%) Query: 44 VTVIGSGPGGYVAA--IKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMA 101 +IG G AA I V +EK E Y + Sbjct: 39 YVIIGGDAAGMSAAMQIVRNDENANVVTLEKGEI---------------------YSYAQ 77 Query: 102 HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQ 161 G + G S +L + + GI + ++V V+ KI Sbjct: 78 CGLPYVISGAIASTEKLIARNVKTFRDKY------GIDAKVR-HEVTKVDTEKKIVYAEH 130 Query: 162 VTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPE------- 214 +LIATG D + +++ + Sbjct: 131 TKTKDV----FEFSYDRLLIATGVRPVMPEWEGRDLQGVHLLKTIPDAERILKTLETNKV 186 Query: 215 -KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFK 273 + +IG G IG+E+ + LG V +E H+G D ++++ + K + Sbjct: 187 EDVTIIGGGAIGLEMAETFVELGKKVRMIERNDHIG-TIYDGDMAEYIYKEADKHHIEIL 245 Query: 274 LNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDP 333 N V +EA K D++LV +G +P T LE I + Sbjct: 246 TNENVKAFKGNE------RVEAVETDKG-TYKADLVLVSVGVKPNTD--FLEGTNIRTNH 296 Query: 334 RGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHK----------AEDEGIICVEGMAGGAVH 383 +G I VN QT + ++YA GD + + A +G + M Sbjct: 297 KGAIEVNAYMQTNVQDVYAAGDCATHYHVIKEIHDHIPIGTTANKQGRLAGLNMLDKRRA 356 Query: 384 IDYNCVPSVI-YTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKIL 442 +I + + +A G +E++ K I YK K + NA +K+L Sbjct: 357 FKGTLGTGIIKFMNLTLARTGLNEKEAKGLHIPYKTVKVDSTNMAGYYPNAK-PLYLKLL 415 Query: 443 GQKSTDRVLGAHILG-PGAGEMVNEAALALEYGASCEDIARVCHAH-PTLSEAFREANLA 500 + T ++LG ++G G + ++ A+AL S D+ V ++ P + + A Sbjct: 416 YRSDTKQLLGGQVIGEEGVDKRIDVIAMALFNKMSIHDLEDVDLSYAPPYNSVWDPIQQA 475 Query: 501 AS 502 A Sbjct: 476 AR 477 Score = 36.4 bits (83), Expect = 0.026, Method: Composition-based stats. Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 4/60 (6%) Query: 22 HGLQGLSAVPLRTYADQPIDA----DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLG 77 G+ L +P + ++ DVT+IG G G A +LG K IE+N+ +G Sbjct: 163 QGVHLLKTIPDAERILKTLETNKVEDVTIIGGGAIGLEMAETFVELGKKVRMIERNDHIG 222 >5ER0-A nrPDB Length = 518 Score = 191 bits (485), Expect = 8e-49, Method: Composition-based stats. Identities = 66/345 (19%), Positives = 132/345 (38%), Gaps = 30/345 (8%) Query: 158 GKNQVTATKADGGTQVID-TKNILIATGSEV--TPFPGITIDEDTIVSS----TGALSLK 210 + VT Q + +++ +GS PGI D + + + Sbjct: 135 DQKTVTVEDLTNHAQTTESYDKLVMTSGSWPIVPKIPGIDSDRVKLCKNWAHAQALIEDA 194 Query: 211 KVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGF 270 K +++ VIGAG IG EL + G DVT ++ + V D + + ++ + G Sbjct: 195 KEAKRITVIGAGYIGAELAEAYSTTGHDVTLIDAMARVMPKYFDADFTDVIEQDYRDHGV 254 Query: 271 KFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIE 330 + L V T + G ++I+ D+ ++CIG RP T L + ++ Sbjct: 255 QLALGETVESFTDSATG---LTIKTDKNS----YETDLAILCIGFRPNTDLL---KGKVD 304 Query: 331 LDPRGRIPVNTRFQTKIPNIYAIGDVV----------AGPMLAHKAEDEGIICVEGMAGG 380 + P G I + ++ P+I+A GD A LA A +GI+ + + Sbjct: 305 MAPNGAIITDDYMRSSNPDIFAAGDSAAVHYNPTHQNAYIPLATNAVRQGILVGKNLVKP 364 Query: 381 AVHIDYNCVPS-VIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMV 439 V S + + G + K++G+ + + + ++ Sbjct: 365 TVKYMGTQSSSGLALYDRTIVSTGLTLAAAKQQGLNAEQVIVEDNYRPEFMPSTE-PVLM 423 Query: 440 KILGQKSTDRVLGAHILG-PGAGEMVNEAALALEYGASCEDIARV 483 ++ T R+LG ++ + N ++ ++ + +D+A V Sbjct: 424 SLVFDPDTHRILGGALMSKYDVSQSANTLSVCIQNENTIDDLAMV 468 Score = 29.9 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 14/73 (19%), Positives = 28/73 (38%), Gaps = 4/73 (5%) Query: 263 RILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNL 322 LQK G ++N V + V++E + + D L++ G P + Sbjct: 114 EELQKLGANVQMNHNVLAIDPD---QKTVTVEDLTNHAQTTESYDKLVMTSGSWPIVPKI 170 Query: 323 -GLEELGIELDPR 334 G++ ++L Sbjct: 171 PGIDSDRVKLCKN 183 >1NHQ-A nrPDB Length = 447 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 90/420 (21%), Positives = 159/420 (37%), Gaps = 61/420 (14%) Query: 110 GIEMSEVRLNLDKMME----QKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGK------ 159 G E E LNL E +K + L+ G+ L+ + KV VN +TG+ Sbjct: 12 GYEAVEELLNLHPDAEIQWYEKGDFISFLSSGM-QLYLEGKVKDVNSVRYMTGEKMESRG 70 Query: 160 ----------------NQVTATKADGGTQVID-TKNILIATGSEV--TPFPGITIDEDTI 200 +QVT G + ++ ++I+ G+ PG +D + Sbjct: 71 VNVFSNTEITAIQPKEHQVTVKDLVSGEERVENYDKLIISPGAVPFELDIPGKDLDNIYL 130 Query: 201 VS-STGALSLKKV---PE--KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGID 254 + A+ LK+ PE +VVIG+G IG+E + + G VT ++ L GV +D Sbjct: 131 MRGRQWAIKLKQKTVDPEVNNVVVIGSGYIGIEAAEAFAKAGKKVTVIDILDRPLGVYLD 190 Query: 255 MEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIG 314 E + ++ V DG++ + + D+++V +G Sbjct: 191 KEFTDVLTEEMEANNITIATGETVERYE--GDGRVQKVVTDKNA-----YDADLVVVAVG 243 Query: 315 RRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVA----------GPMLAH 364 RP T L + +EL P G I + +T P+++A+GD LA Sbjct: 244 VRPNTAWL---KGTLELHPNGLIKTDEYMRTSEPDVFAVGDATLIKYNPADTEVNIALAT 300 Query: 365 KAEDEGIICVEGMAGGAVHIDYNCVPS--VIYTHPEVAWVGKSEEQLKEEGIEYKVGKFP 422 A +G V+ + S ++ + A G +E ++ G E K Sbjct: 301 NARKQGRFAVKNLEEPVKPFPGVQGSSGLAVF-DYKFASTGINEVMAQKLGKETKAVTVV 359 Query: 423 FAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGAGEM-VNEAALALEYGASCEDIA 481 K++ T ++LGA ++ +N +LA++ + ED+A Sbjct: 360 EDYLMDFNP-DKQKAWFKLVYDPETTQILGAQLMSKADLTANINAISLAIQAKMTIEDLA 418 Score = 34.1 bits (77), Expect = 0.13, Method: Composition-based stats. Identities = 16/43 (37%), Positives = 21/43 (48%) Query: 29 AVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIE 71 A+ L+ P +V VIGSG G AA A+ G K I+ Sbjct: 137 AIKLKQKTVDPEVNNVVVIGSGYIGIEAAEAFAKAGKKVTVID 179 >3OC4-A nrPDB Length = 452 Score = 188 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 94/484 (19%), Positives = 181/484 (37%), Gaps = 73/484 (15%) Query: 44 VTVIGSGPGGYVAAIKAAQL--GFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMA 101 + +IG+ G AAI + + + I+K T+G Sbjct: 5 IVIIGASFAGISAAIASRKKYPQAEISLIDKQATVG------------------------ 40 Query: 102 HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQ 161 + S G+ ++++ E + + L L +VV + +NQ Sbjct: 41 ----YLSGGLSA-YFNHTINELHEARYITEEELRRQKIQLLLNREVV------AMDVENQ 89 Query: 162 VTATKADGGTQVIDTKNILIATGSE--VTPFPGIT---IDEDTIVS-STGALSLKKVPEK 215 + A Q +++ATG+ T G + + +S + A+ L + + Sbjct: 90 LIAWTRKEEQQWYSYDKLILATGASQFSTQIRGSQTEKLLKYKFLSGALAAVPLLENSQT 149 Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 + VIGAG IG+E ++ V E L ++ D E+ Q+ L+KQ F Sbjct: 150 VAVIGAGPIGMEAIDFLVKMKKTVHVFESLENLLPKYFDKEMVAEVQKSLEKQAVIFHFE 209 Query: 276 TKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRG 335 V G + ++G + + + I+CD + + P L + I+ + Sbjct: 210 ETVLGIEETANGIVLET-------SEQEISCDSGIFALNLHP---QLAYLDKKIQRNLDQ 259 Query: 336 RIPVNTRFQTKIPNIYAIGD---VVAGP-------MLAHKAEDEGIICVEGMAGGAVHID 385 I V+ QT +PN++AIGD V+ P L + A G++ + Sbjct: 260 TIAVDAYLQTSVPNVFAIGDCISVMNEPVAETFYAPLVNNAVRTGLVVANNLEEKTHRFI 319 Query: 386 YNC-VPSVIYTHPEVAWVGKSEEQ--LKEEGIEYKVGKFPFAANSRAKTNADTDGMVKIL 442 + +A G +E + + + + + P T+ + K++ Sbjct: 320 GSLRTMGTKVGDYYLASTGLTETEGLFFPQTLASIIVRQPAPP-----LQHGTEILGKLI 374 Query: 443 GQKSTDRVLGAHILGP-GAGEMVNEAALALEYGASCEDIARVCHAH-PTLSEAFREANLA 500 K T RVLGA + E +N AL+++ G + D+ + + + P+L+ + NL Sbjct: 375 YDKVTQRVLGAQLCSKNNCLEKINTLALSIQTGQTLTDLLQKDYFYQPSLTNIYDITNLM 434 Query: 501 ASFG 504 + Sbjct: 435 GASA 438 >2A87-A nrPDB Length = 335 Score = 174 bits (442), Expect = 6e-44, Method: Composition-based stats. Identities = 83/354 (23%), Positives = 127/354 (35%), Gaps = 52/354 (14%) Query: 27 LSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCI 86 ++A P+ A P+ DV VIGSGP GY AA+ AA+ + E + GG + + Sbjct: 1 MTAPPVHDRAHHPV-RDVIVIGSGPAGYTAALYAARAQLAPLVFE-GTSFGGALMTTTDV 58 Query: 87 PSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNK 146 + N GI E+ +D+M EQ AL G + Sbjct: 59 ENYPGFRN---------------GITGPEL---MDEMREQ------ALRFGAD--LRMED 92 Query: 147 VVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGA 206 V V+ +G + ADG T + + + PG VSS Sbjct: 93 VESVSLHGPLKS-----VVTADGQTHRARAVILAMGAAARYLQVPGEQELLGRGVSSCAT 147 Query: 207 LS-LKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRIL 265 + + VIG G +E + R VT V I ++ ++N + Sbjct: 148 CDGFFFRDQDIAVIGGGDSAMEEATFLTRFARSVTLVHRRDEFRASKIMLDRARNNDK-- 205 Query: 266 QKQGFKFKLNTKVTGATKKSDGKIDVS---IEAASGGKAEVITCDVLLVCIGRRPFTKNL 322 +F N V DG V+ + + G + + V IG P + Sbjct: 206 ----IRFLTNHTVVAV----DGDTTVTGLRVRDTNTGAETTLPVTGVFVAIGHEPRS--- 254 Query: 323 GLEELGIELDPRGRIPVNTRFQ-TKIPNIYAIGDVVAG-PMLAHKAEDEGIICV 374 GL I++DP G + V R T +P ++A GD+V A A G Sbjct: 255 GLVREAIDVDPDGYVLVQGRTTSTSLPGVFAAGDLVDRTYRQAVTAAGSGCAAA 308 >4GCM-A nrPDB Length = 312 Score = 172 bits (436), Expect = 3e-43, Method: Composition-based stats. Identities = 82/353 (23%), Positives = 131/353 (37%), Gaps = 55/353 (15%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYH 99 ID D+ +IG+GP G AA+ A++ KTV IE+ + G + + + N + Sbjct: 5 IDFDIAIIGAGPAGMTAAVYASRANLKTVMIERG-------IPGGQMANTEEVENFPGFE 57 Query: 100 MAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGK 159 M G D ++ KM E G + + K V G K+ Sbjct: 58 MITGPDLST-------------KMFEHAKK------FGAVYQYGDIKSVEDKGEYKVI-- 96 Query: 160 NQVTATKADGGTQVIDTKNILIATGSEVTPF--PGITIDEDTIVS----STGALSLKKVP 213 + G + + K ++IATG+E PG VS GA Sbjct: 97 --------NFGNKELTAKAVIIATGAEYKKIGVPGEQELGGRGVSYCAVCDGAFFKN--- 145 Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFK 273 +++ VIG G VE G+ + VT V + I + R + F Sbjct: 146 KRLFVIGGGDSAVEEGTFLTKFADKVTIVHRRDELRAQRILQD------RAFKNDKIDFI 199 Query: 274 LNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDP 333 + + +K V++ + G E D + + IG +P T ++LGI + Sbjct: 200 WSHTLKSINEKDGKVGSVTLTSTKDGSEETHEADGVFIYIGMKPLTAPF--KDLGI-TND 256 Query: 334 RGRIPVNTRFQTKIPNIYAIGDVVA-GPMLAHKAEDEGIICVEGMAGGAVHID 385 G I T +P I+A GDV G A +G I + A H++ Sbjct: 257 VGYIVTKDDMTTSVPGIFAAGDVRDKGLRQIVTATGDGSIAAQSAAEYIEHLN 309 >2CDU-A nrPDB Length = 452 Score = 172 bits (436), Expect = 3e-43, Method: Composition-based stats. Identities = 65/351 (18%), Positives = 123/351 (35%), Gaps = 37/351 (10%) Query: 157 TGKNQVTATKAD---GGTQVIDTKNILIATGSEV--TPFPGITIDEDTIVSSTGALSLKK 211 T D + +++ TGS+ P PGI D + KK Sbjct: 84 VDPETKTIKVKDLITNEEKTEAYDKLIMTTGSKPTVPPIPGI--DSSRVYLCKNYNDAKK 141 Query: 212 V------PEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRIL 265 + + + +IG+G IG EL + +V ++ V D E + + Sbjct: 142 LFEEAPKAKTITIIGSGYIGAELAEAYSNQNYNVNLIDGHERVLYKYFDKEFTDILAKDY 201 Query: 266 QKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLE 325 + G L +KV + D I ++ + I D+ ++CIG RP T+ L Sbjct: 202 EAHGVNLVLGSKVAAFEEVDDEIITKTL------DGKEIKSDIAILCIGFRPNTELL--- 252 Query: 326 ELGIELDPRGRIPVNTRFQTKIPNIYAIGDVV----------AGPMLAHKAEDEGIICVE 375 + + + G I + + +I+A GD A LA A +G + Sbjct: 253 KGKVAMLDNGAIITDEYMHSSNRDIFAAGDSAAVHYNPTNSNAYIPLATNAVRQGRLVGL 312 Query: 376 GMAGGAVH-IDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNAD 434 + V + + G + K + KV + A N R + Sbjct: 313 NLTEDKVKDMGTQSSSGLKLYGRTYVSTGINTALAKANNL--KVSEVIIADNYRPEFMLS 370 Query: 435 T-DGMVKILGQKSTDRVLGAHILG-PGAGEMVNEAALALEYGASCEDIARV 483 T + ++ ++ T +LG + + N ++ ++ + +D+A V Sbjct: 371 TDEVLMSLVYDPKTRVILGGALSSMHDVSQSANVLSVCIQNKNTIDDLAMV 421 >3IWA-A nrPDB Length = 472 Score = 172 bits (435), Expect = 4e-43, Method: Composition-based stats. Identities = 101/493 (20%), Positives = 177/493 (35%), Gaps = 67/493 (13%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFK--TVCIEKNETLGGTCLNVGC-IPSKALLNNSHYYHM 100 V VIG+ G AA + +L + I++ + GC IP S+ + Sbjct: 6 VVVIGAVALGPKAACRFKRLDPEAHVTMIDQASRIS----YGGCGIPYYVSGEVSNIESL 61 Query: 101 AHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKN 160 R E + +++ ++E ++ A+ + Sbjct: 62 QATPYNVVRDPEFFRINKDVEALVETRAHAIDR------------------------AAH 97 Query: 161 QVTATKA-DGGTQVIDTKNILIATGSE--VTPFPGITIDEDTIVSSTG-------ALSLK 210 V G + + +++A GS+ P G+ + T V++ A+S Sbjct: 98 TVEIENLRTGERRTLKYDKLVLALGSKANRPPVEGMDLAGVTPVTNLDEAEFVQHAISAG 157 Query: 211 KVPEKMVVIGAGVIGVELGSVWQRL-GADVTAVEFLGHVGGVGIDMEISKNFQRILQKQG 269 +V K V++G G IG+E+ + G D T VE + +S+ + L+K Sbjct: 158 EV-SKAVIVGGGFIGLEMAVSLADMWGIDTTVVELADQIMPGFTSKSLSQMLRHDLEKND 216 Query: 270 FKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGI 329 KV +GK+ I + D++++ G P T+ + G+ Sbjct: 217 VVVHTGEKVVRLE-GENGKVARVITDK-----RTLDADLVILAAGVSPNTQL--ARDAGL 268 Query: 330 ELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLA----------HKAEDEGIICVEGMAG 379 ELDPRG I V+TR +T P+I+A GD V P L A +G + +A Sbjct: 269 ELDPRGAIIVDTRMRTSDPDIFAGGDCVTIPNLVTGKPGFFPLGSMANRQGRVIGTNLAD 328 Query: 380 GAVHIDYNCVPSVIYTHPEVAW-VGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGM 438 G + A G + E EG + + T Sbjct: 329 GDATFPGAVGSWAVKLFEGSASGAGLTVEGALREGYDAVNVHVEQFDRAHFYPE-KTIMT 387 Query: 439 VKILGQKSTDRVLGAHI---LGPGAGEMVNEAALALEYGASCEDIARVCHAH-PTLSEAF 494 ++++ + T RVLG LG +N A L + EDI+ + P + A Sbjct: 388 LQLVVDRPTRRVLGIQGFSTLGDALTARINAVATMLASKPTVEDISNAEVVYSPPFASAM 447 Query: 495 REANLAASFGKSI 507 N+A + ++ Sbjct: 448 DIVNVAGNVADNV 460 Score = 33.8 bits (76), Expect = 0.20, Method: Composition-based stats. Identities = 26/136 (19%), Positives = 50/136 (36%), Gaps = 19/136 (13%) Query: 214 EKMVVIGAGVIGVELGSVWQRLG--ADVTAVEFLGHV------GGVGIDMEISKNFQRIL 265 + +VVIGA +G + ++RL A VT ++ + + E+S Sbjct: 4 KHVVVIGAVALGPKAACRFKRLDPEAHVTMIDQASRISYGGCGIPYYVSGEVSNIESLQA 63 Query: 266 QKQGFK-----FKLNTKVTGATKKSDGKI-----DVSIEAASGGKAEVITCDVLLVCIGR 315 F++N V + I V IE G+ + D L++ +G Sbjct: 64 TPYNVVRDPEFFRINKDVEALVETRAHAIDRAAHTVEIENLRTGERRTLKYDKLVLALGS 123 Query: 316 RPFTKNL-GLEELGIE 330 + + G++ G+ Sbjct: 124 KANRPPVEGMDLAGVT 139 >1YQZ-A nrPDB Length = 438 Score = 159 bits (402), Expect = 3e-39, Method: Composition-based stats. Identities = 77/387 (19%), Positives = 156/387 (40%), Gaps = 43/387 (11%) Query: 143 KQNKVVHVNGYGKITGK-NQVTATKADGGTQ-VIDTKNILIATGSEVTPFPGITIDEDTI 200 KQ V + I + V+ Q ++++ G+ G D Sbjct: 71 KQITVKTYHEVIAINDERQTVSVLNRKTNEQFEESYDKLILSPGASANSL-GFESDITFT 129 Query: 201 VSS-------TGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGI 253 + + + +V +K++V+GAG + +E+ G T + + + Sbjct: 130 LRNLEDTDAIDQFIKANQV-DKVLVVGAGYVSLEVLENLYERGLHPTLIHRSDKIN-KLM 187 Query: 254 DMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCI 313 D ++++ L K+ ++LN ++ +++ ++ V D+++ + Sbjct: 188 DADMNQPILDELDKREIPYRLNEEINAI-----NGNEITFKSGK-----VEHYDMIIEGV 237 Query: 314 GRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVV----------AGPMLA 363 G P +K +E I+LD +G IPVN +F+T +PNIYAIGD+ A LA Sbjct: 238 GTHPNSK--FIESSNIKLDRKGFIPVNDKFETNVPNIYAIGDIATSHYRHVDLPASVPLA 295 Query: 364 HKAEDEGIICVEGMAGGAVHIDYNCVPS---VIYTHPEVAWVGKSEEQLKEEGIEYKVGK 420 A I E +AG I++ V + A VG +LK+ +YK+ + Sbjct: 296 WGAHRAASIVAEQIAGNDT-IEFKGFLGNNIVKFFDYTFASVGVKPNELKQ--FDYKMVE 352 Query: 421 FPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILG-PGAGEMVNEAALALEYGASCED 479 A++ ++ +++ S ++L A +G GA + ++ ++A+ + ++ Sbjct: 353 VTQGAHANYYP-GNSPLHLRVYYDTSNRQILRAAAVGKEGADKRIDVLSMAMMNQLTVDE 411 Query: 480 IARVCHAH-PTLSEAFREANLAASFGK 505 + A+ P S N+ K Sbjct: 412 LTEFEVAYAPPYSHPKDLINMIGYKAK 438 >5JCN-A nrPDB Length = 451 Score = 151 bits (382), Expect = 6e-37, Method: Composition-based stats. Identities = 55/258 (21%), Positives = 98/258 (37%), Gaps = 38/258 (14%) Query: 171 TQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVP--------------EKM 216 + ++IATGS V S L L++V K Sbjct: 127 GATFTYEILIIATGSSVIKLSDF---GTQGADSNNILYLREVDDADKLVAAIQAKKGGKA 183 Query: 217 VVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNT 276 V++G G IG+EL + + DVT V +I+ ++ +G K T Sbjct: 184 VIVGGGYIGLELSAALKINDFDVTMVFPEPWCMPRLFTADIAAFYESYYTNKGVKIVKGT 243 Query: 277 KVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGR 336 G ++G + + V+ D+++V +G RP T G + +G Sbjct: 244 VAVGFDADANGDVTAV----NLKNGSVLEADIVVVGVGGRPLTTLFK----GQVAEEKGG 295 Query: 337 IPVNTRFQTKIPNIYAIGDVVAGPML-------------AHKAEDEGIICVEGMAGGAVH 383 I + F+T +P +YA+GDV PM A K+ ++ + ++G G Sbjct: 296 IKTDAFFETSVPGVYAVGDVATFPMKMYNELRRVEHVDHARKSAEQAVKAIKGKESGESV 355 Query: 384 IDYNCVPSVIYTHPEVAW 401 ++Y+ +P ++ W Sbjct: 356 VEYDYLPYFFSRSFDLGW 373 >5UTH-A nrPDB Length = 319 Score = 139 bits (350), Expect = 3e-33, Method: Composition-based stats. Identities = 70/324 (21%), Positives = 114/324 (35%), Gaps = 55/324 (16%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 102 DV +IGSGP GY AAI AA+ K + E + GG + + + Sbjct: 17 DVIIIGSGPAGYTAAIYAARAQLKPLVFEGTQ-FGGALMTTTEVENYPGFR--------- 66 Query: 103 GKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQV 162 GI E+ +D+M EQ AL G + V V G Sbjct: 67 ------EGITGPEL---MDQMREQ------ALRFGAD--LRMEDVDAVQLEGP------- 102 Query: 163 TATKADGGTQVIDTKNILIATGSEVTPF--PGIT----IDEDTIVSSTGALSLKKVPEKM 216 G + + +++A G+ PG + T + G + + Sbjct: 103 -VKTVVVGDETHQARAVILAMGAAARHLGVPGEEALTGMGVSTCATCDGFFFRD---QDI 158 Query: 217 VVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNT 276 VV+G G +E + R VT + I +E ++ ++ F NT Sbjct: 159 VVVGGGDSAMEEATFLTRFARSVTLIHRRDEFRASKIMLERARANEK------ITFLTNT 212 Query: 277 KVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGR 336 ++T V + G+ + + V IG P ++ L +ELD G Sbjct: 213 EITQIE-GDPKVTGVRLRDTVTGEESKLDVTGVFVAIGHDPRSE---LVRGQVELDDEGY 268 Query: 337 IPVNTRFQ-TKIPNIYAIGDVVAG 359 + V R T + ++A GD+V Sbjct: 269 VKVQGRTTYTSLDGVFAAGDLVDH 292 >2V3B-A nrPDB Length = 384 Score = 138 bits (349), Expect = 4e-33, Method: Composition-based stats. Identities = 80/435 (18%), Positives = 152/435 (34%), Gaps = 82/435 (18%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCI----EKNETLGGTCLNVGCIPSKALLNNSHYYH 99 + +IG+G GY A + +L +T + + + SK +L+ Sbjct: 7 LVIIGTGLAGYNLAREWRKLDGETPLLMITADDGRSY-----------SKPMLSTG---- 51 Query: 100 MAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGK 159 K+ + G+ M+E G +A + H G G Sbjct: 52 --FSKNKDADGLAMAEP-------------------GAMAEQLNARILTHTRVTGIDPGH 90 Query: 160 NQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKV------P 213 ++ G + + +++++A G+E P +D + + Sbjct: 91 QRIWI-----GEEEVRYRDLVLAWGAEPIRVPVEGDAQDALYPINDLEDYARFRQAAAGK 145 Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFK 273 +++++GAG+IG E + G + V V + +K Q L+ G +F Sbjct: 146 RRVLLLGAGLIGCEFANDLSSGGYQLDVVAPCEQVMPGLLHPAAAKAVQAGLEGLGVRFH 205 Query: 274 LNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDP 333 L V + KK+ ++ + EVI CD+++ +G RP T+ G+ ++ Sbjct: 206 LG-PVLASLKKAGEGLEAHLSD-----GEVIPCDLVVSAVGLRPRTELAFA--AGLAVNR 257 Query: 334 RGRIPVNTRFQTKIPNIYAIGDV--VAGPMLAHKA--EDEGIICVEGMAGGAVHIDYNCV 389 I V+ +T NIYA+GD V G L + + +AG + Y + Sbjct: 258 --GIVVDRSLRTSHANIYALGDCAEVDGLNLLYVMPLMACARALAQTLAGNPSQVAYGPM 315 Query: 390 PSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDR 449 P + T V P + +K+L + + R Sbjct: 316 PVTVKTP----ACPL-------------VVSPPPRGMDGQWLVEGSGTDLKVLCRDTAGR 358 Query: 450 VLGAHILGPGAGEMV 464 V+G + G E + Sbjct: 359 VIGYALTGAAVNEKL 373 >5MJK-A nrPDB Length = 327 Score = 136 bits (342), Expect = 3e-32, Method: Composition-based stats. Identities = 70/322 (21%), Positives = 114/322 (35%), Gaps = 54/322 (16%) Query: 41 DADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHM 100 DV +IGSGP G AA+ A+ KT+ +E+ + G + + A + N Y Sbjct: 24 KYDVVIIGSGPAGMTAAMYTARSEMKTLLLERG-------VPGGQMNNTAEIENYPGYET 76 Query: 101 AHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKN 160 G + L+ +A + V + G+ + Sbjct: 77 IMGPE----------------------------LSMKMAEPLEGLGVENAYGFVTGIEDH 108 Query: 161 QVTATKADGGTQVIDTKNILIATGS--EVTPFPGITIDEDTIVS----STGALSLKKVPE 214 K TK+I+IATG+ PG VS GA + Sbjct: 109 G-DYKKIITEDDEFITKSIIIATGANHRKLEIPGEEEYGARGVSYCAVCDGAFFRN---Q 164 Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL 274 +++VIG G VE R G VT + + EI + QR +++ F Sbjct: 165 EILVIGGGDSAVEEALYLTRFGQSVTIMHRRDKLRA----QEIIQ--QRAFKEEKINFIW 218 Query: 275 NTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPR 334 ++ V + G+ + + +G P + + +LGI D Sbjct: 219 DSVPMEIKGDDKKIQSVVYKNVKTGEVTEKAFGGIFIYVGLDPVAE--FVSDLGI-TDEA 275 Query: 335 GRIPVNTRFQTKIPNIYAIGDV 356 G I + +T IP I+A+GDV Sbjct: 276 GWIITDDHMRTNIPGIFAVGDV 297 >2YVG-A nrPDB Length = 408 Score = 133 bits (336), Expect = 1e-31, Method: Composition-based stats. Identities = 75/361 (20%), Positives = 134/361 (37%), Gaps = 76/361 (21%) Query: 36 ADQPIDADVTVIGSG--PGGYVAAIK-AAQLGFKTVCIEKNETLGGTCLNVGCIPSKALL 92 + + + A V V+G+G +VA ++ A G TV ++ E Sbjct: 2 SQEALKAPVVVLGAGLASVSFVAELRQAGYQGLITVVGDEAER----------------- 44 Query: 93 NNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNG 152 Y KDF + G + ++RL+ + E V+ L G A F Sbjct: 45 ---PYDRPPLSKDFMAHG-DAEKIRLDCKRAPE-----VEWLLGVTAQSF---------- 85 Query: 153 YGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFP---GITIDEDTIVSSTGALSL 209 T +DG T + +++ATG+ P G T+ T+ + A + Sbjct: 86 -----DPQAHTVALSDGRT--LPYGTLVLATGAAPRALPTLQGATMPVHTLRTLEDARRI 138 Query: 210 K---KVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQ 266 + + +++++G GVIG+EL + + G V+ VE + ++ R Sbjct: 139 QAGLRPQSRLLIVGGGVIGLELAATARTAGVHVSLVETQPRLMSRAAPATLADFVARYHA 198 Query: 267 KQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEE 326 QG + VT G +D + G + I D+++V IG + Sbjct: 199 AQGVDLRFERSVT-------GSVDGVVLLDDGTR---IAADMVVVGIGVLAN--DALARA 246 Query: 327 LGIELDPRGRIPVNTRFQTKIPNIYAIGDVVA----------GPMLAHKAEDEGIICVEG 376 G+ D I V+ +T P++YA+GDV A+++GI Sbjct: 247 AGLACDD--GIFVDAYGRTTCPDVYALGDVTRQRNPLSGRFERIETWSNAQNQGIAVARH 304 Query: 377 M 377 + Sbjct: 305 L 305 >3FG2-P nrPDB Length = 404 Score = 133 bits (334), Expect = 2e-31, Method: Composition-based stats. Identities = 53/263 (20%), Positives = 96/263 (36%), Gaps = 27/263 (10%) Query: 139 AHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSE--VTPFPGITI- 195 F+ + ++ + A G I+ ++++ATG+ + P ++ Sbjct: 64 EKFFQDQAIELISDRMVSIDREGRKLLLASGTA--IEYGHLVLATGARNRMLDVPNASLP 121 Query: 196 DEDTIVSSTGALSL-KKVP--EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVG 252 D + + + L +++P + +VVIGAG IG+E + + G +V VE V Sbjct: 122 DVLYLRTLDESEVLRQRMPDKKHVVVIGAGFIGLEFAATARAKGLEVDVVELAPRVMARV 181 Query: 253 IDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVC 312 + EIS F G + + T + D V + + + CD+++V Sbjct: 182 VTPEISSYFHDRHSGAGIRMHYGVRATEIAAEGDRVTGVVLSDGN-----TLPCDLVVVG 236 Query: 313 IGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDV----------VAGPML 362 +G P + L I V+ + T P+I AIGD Sbjct: 237 VGVIPNVEIAAAAGLPTAAG----IIVDQQLLTSDPHISAIGDCALFESVRFGETMRVES 292 Query: 363 AHKAEDEGIICVEGMAGGAVHID 385 A D+ + G A D Sbjct: 293 VQNATDQARCVAARLTGDAKPYD 315 Score = 28.0 bits (61), Expect = 9.9, Method: Composition-based stats. Identities = 10/28 (35%), Positives = 13/28 (46%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIE 71 V VIG+G G A A G + +E Sbjct: 145 VVVIGAGFIGLEFAATARAKGLEVDVVE 172 >5UWY-A nrPDB Length = 308 Score = 131 bits (330), Expect = 7e-31, Method: Composition-based stats. Identities = 67/321 (20%), Positives = 103/321 (32%), Gaps = 54/321 (16%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMA 101 D +IGSGP G AA+ AA+ IE+ G + + + N Y Sbjct: 5 YDTLIIGSGPAGMTAALYAARSNLSVAIIEQGAP-------GGQMNNTFDIENYPGYDHI 57 Query: 102 HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQ 161 G + A + E E + N++ + Sbjct: 58 SGPELAMKMYEPLE-KFNVENIYGIVQKIEN-----------------------FGDYKC 93 Query: 162 VTATKADGGTQVIDTKNILIATGS--EVTPFPGITIDEDTIVS----STGALSLKKVPEK 215 V A + K ++IATG+ V PG VS GA + Sbjct: 94 VLTEDAS-----YEAKTVIIATGAKYRVLGVPGEEYYTSRGVSYCAVCDGAFFRD---QD 145 Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 ++V+G G VE + VT V + I + R F + Sbjct: 146 LLVVGGGDSAVEEAIYLTQFAKKVTVVHRRDQLRAQKILQD------RAFANDKVDFIWD 199 Query: 276 TKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRG 335 + V +V IE G+ + + +G P T + E+ D G Sbjct: 200 SVVKEIQGNDIKVSNVLIENVKTGQVTDHAFGGVFIYVGMNPVTGMVKDLEI---TDSEG 256 Query: 336 RIPVNTRFQTKIPNIYAIGDV 356 I + +T IP I+AIGDV Sbjct: 257 WIITDDHMRTSIPGIFAIGDV 277 Score = 31.4 bits (70), Expect = 1.1, Method: Composition-based stats. Identities = 10/37 (27%), Positives = 15/37 (40%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETL 76 D D+ V+G G AI Q K + + + L Sbjct: 142 RDQDLLVVGGGDSAVEEAIYLTQFAKKVTVVHRRDQL 178 >3F8P-A nrPDB Length = 323 Score = 128 bits (322), Expect = 6e-30, Method: Composition-based stats. Identities = 70/355 (19%), Positives = 120/355 (33%), Gaps = 53/355 (14%) Query: 27 LSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCI 86 +S +P T DV ++G GP Y AA+ +A+ KT+ I ET GG Sbjct: 1 MSLLPRTTSVKPGEKFDVIIVGLGPAAYGAALYSARYMLKTLVI--GETPGG-------- 50 Query: 87 PSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNK 146 D+ + + M++ + ++ + Sbjct: 51 ---------QLTEAGIVDDYLGL------IEIQASDMIKVFNKHIEK----YEVPVLLDI 91 Query: 147 VVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPF--PGITIDEDTIVSST 204 V + G V TK G ++++ G + PG +S Sbjct: 92 VEKIENRG----DEFVVKTKRKGE---FKADSVILGIGVKRRKLGVPGEQEFAGRGISYC 144 Query: 205 GALSLKKVPEKMV-VIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQR 263 ++V VIG G +E + V + I +E K Sbjct: 145 SVCDAPLFKNRVVAVIGGGDSALEGAEILSSYSTKVYLIHRRDTFKAQPIYVETVK---- 200 Query: 264 ILQKQGFKFKLNTKVTGATKKSDGKI-DVSIEAASGGKAEVITCDVLLVCIGRRPFTKNL 322 +K +F LN+ V K D + V +E G+ + + + + + IG P T Sbjct: 201 --KKPNVEFVLNSVVKEI--KGDKVVKQVVVENLKTGEIKELNVNGVFIEIGFDPPTD-- 254 Query: 323 GLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVA---GPMLAHKAEDEGIICV 374 + GIE D G I V+ +T +P ++A GD + G A +G + Sbjct: 255 FAKSNGIETDTNGYIKVDEWMRTSVPGVFAAGDCTSAWLGFRQVITAVAQGAVAA 309 >1Q1R-A nrPDB Length = 431 Score = 128 bits (321), Expect = 7e-30, Method: Composition-based stats. Identities = 54/279 (19%), Positives = 103/279 (36%), Gaps = 36/279 (12%) Query: 155 KITGKNQVTATKAD------GGTQVIDTKNILIATGSEVTPFPGITIDED------TIVS 202 ++ G QVTA D + +D +++ATG P P + + + Sbjct: 76 QLLGGTQVTAINRDRQQVILSDGRALDYDRLVLATGGRPRPLPVASGAVGKANNFRYLRT 135 Query: 203 STGALSLKKV---PEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISK 259 A +++ ++VVIG G IG+E+ + + VT ++ V +S Sbjct: 136 LEDAECIRRQLIADNRLVVIGGGYIGLEVAATAIKANMHVTLLDTAARVLERVTAPPVSA 195 Query: 260 NFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFT 319 ++ + ++ G + T+V G +D + ++ G + + D+++ IG P Sbjct: 196 FYEHLHREAGVDIRTGTQVCGFEMSTDQQKVTAVLCEDGTR---LPADLVIAGIGLIPNC 252 Query: 320 KNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVA----------GPMLAHKAEDE 369 + G+++D I +N QT P I A+GD A ++ Sbjct: 253 ELASA--AGLQVD--NGIVINEHMQTSDPLIMAVGDCARFHSQLYDRWVRIESVPNALEQ 308 Query: 370 GIICVEGMAGGAVHIDYNCVPSVIYTHPEVA--WVGKSE 406 + G + P E+ VG SE Sbjct: 309 ARKIAAILCGKVPRDE--AAPWFWSDQYEIGLKMVGLSE 345 Score = 36.4 bits (83), Expect = 0.030, Method: Composition-based stats. Identities = 21/135 (15%), Positives = 43/135 (31%), Gaps = 22/135 (16%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGAD-----VTAVEFLGHVGGVGIDMEISKNFQ------ 262 + +V++G G+ GVE+ + G + V + H ++ Sbjct: 5 DNVVIVGTGLAGVEVAFGLRASGWEGNIRLVGDATVIPHHLPPLSKAYLAGKATAESLYL 64 Query: 263 ---RILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFT 319 Q + T+VT + + V + + D L++ G RP Sbjct: 65 RTPDAYAAQNIQLLGGTQVTAINRD---RQQVILSD-----GRALDYDRLVLATGGRPRP 116 Query: 320 KNLGLEELGIELDPR 334 + +G + R Sbjct: 117 LPVASGAVGKANNFR 131 >4ZN0-A nrPDB Length = 311 Score = 127 bits (319), Expect = 1e-29, Method: Composition-based stats. Identities = 67/341 (19%), Positives = 115/341 (33%), Gaps = 56/341 (16%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMA 101 D+ +IG GP G A I A + G T+ +E+NE G Sbjct: 8 YDLIIIGGGPAGLTAGIYAVRYGLDTLILERNEISG------------------QISMAD 49 Query: 102 HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQ 161 +++ ++ ++ME+ T + + G+ + V G KI Sbjct: 50 IVENYPGF------PSISGLELMERFRTHAQEV--GVKTTITEVLSVRSEGTKKI----- 96 Query: 162 VTATKADGGTQVIDTKNILIATGSEVTPF--PGITIDEDTIVSSTGALSLKKVPEK-MVV 218 +T D ++ K ++IATG+ PG VS K + V Sbjct: 97 ITTDSGD-----LEAKAVIIATGANPKHLGVPGEKELISKGVSYCAICDGPFFRNKIVAV 151 Query: 219 IGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKV 278 +G G V ++ V V H+ + + + LN+ V Sbjct: 152 VGGGNSAVTDALFLSKVAQKVYLVHRRDHLKAARVLQDRVDGTP------NIELILNSHV 205 Query: 279 TGATKKSDGKIDV---SIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRG 335 +G V +E + + ++ + + + +G P T E + +E D G Sbjct: 206 LEIVGTREGIKKVEKIILEDVNSRETRELSTNGVFIYVGIHPNT-----EFVDVEKDEGG 260 Query: 336 RIPVNTRFQTKIPNIYAIGDVVAGP--MLAHKAEDEGIICV 374 I + +T IYA GD P L A +G I Sbjct: 261 FIKTDRWMETSEKGIYAAGDCRDTPIWQLV-TAVRDGAIAA 300 >2Q7V-A nrPDB Length = 325 Score = 122 bits (306), Expect = 4e-28, Method: Composition-based stats. Identities = 68/359 (18%), Positives = 114/359 (31%), Gaps = 66/359 (18%) Query: 27 LSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCI 86 ++A D DV +IG GP G AAI + T+ +EK GG Sbjct: 1 MTAPTAH-------DYDVVIIGGGPAGLTAAIYTGRAQLSTLILEKGMP-GG-------- 44 Query: 87 PSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNK 146 ++F ++ + L + + + + Sbjct: 45 ---------QIAWSEEVENFPGFPEPIAGMEL------------AQRMHQQAEKFGAKVE 83 Query: 147 VVHVNG--YGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITI-------DE 197 + V G + + T +G K +++ATG++ GI Sbjct: 84 MDEVQGVQHDATSHPYPFTVRGYNGE---YRAKAVILATGADPRKL-GIPGEDNFWGKGV 139 Query: 198 DTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEI 257 T + G +K+VVIG G VE G + +VT + + + Sbjct: 140 STCATCDGFF---YKGKKVVVIGGGDAAVEEGMFLTKFADEVTVIHRRDTLRANKVAQ-- 194 Query: 258 SKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRP 317 R KF +T V + +D V + G+ + D + + IG P Sbjct: 195 ----ARAFANPKMKFIWDTAVEEI-QGADSVSGVKLRNLKTGEVSELATDGVFIFIGHVP 249 Query: 318 FTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGP--MLAHKAEDEGIICV 374 T + + L G + V T IP ++A GDV LA + G Sbjct: 250 NTA---FVKDTVSLRDDGYVDVRDEIYTNIPMLFAAGDVSDYIYRQLA-TSVGAGTRAA 304 >3LXD-A nrPDB Length = 415 Score = 120 bits (301), Expect = 2e-27, Method: Composition-based stats. Identities = 54/269 (20%), Positives = 87/269 (32%), Gaps = 33/269 (12%) Query: 157 TGKNQVTATKADGGTQVIDTKNILIATGSEVTPFP--GITIDEDTIVSSTGALS-----L 209 T DG I+ ++ ATG + G + V + L Sbjct: 91 LDPAAHTVKLGDGSA--IEYGKLIWATGGDPRRLSCVGADLAGVHAVRTKEDADRLMAEL 148 Query: 210 KKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQG 269 + VVIG G IG+E +V + G +VT +E L V +S+ +Q + G Sbjct: 149 DAGAKNAVVIGGGYIGLEAAAVLTKFGVNVTLLEALPRVLARVAGEALSEFYQAEHRAHG 208 Query: 270 FKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGI 329 + + V ++ VI D+++V IG P L Sbjct: 209 VDLRTGAAMDCIEGDGTKVTGVRMQD-----GSVIPADIVIVGIGIVPCVGALISAGA-- 261 Query: 330 ELDPRGRIPVNTRFQTKIPNIYAIGDVVA-----------GPMLAHKAEDEGIICVEGMA 378 + V+ +T + ++YAIGD A A D + + Sbjct: 262 --SGGNGVDVDEFCRTSLTDVYAIGDCAAHANDFADGAVIRLESVQNANDMATAAAKDIC 319 Query: 379 GGAVHIDYNCVPSVIYTHPEVA--WVGKS 405 G V Y P ++ VG S Sbjct: 320 GAPVP--YKATPWFWSNQYDLKLQTVGLS 346 Score = 28.0 bits (61), Expect = 9.9, Method: Composition-based stats. Identities = 9/32 (28%), Positives = 12/32 (37%) Query: 45 TVIGSGPGGYVAAIKAAQLGFKTVCIEKNETL 76 VIG G G AA + G +E + Sbjct: 156 VVIGGGYIGLEAAAVLTKFGVNVTLLEALPRV 187 >4EMJ-A nrPDB Length = 410 Score = 119 bits (299), Expect = 3e-27, Method: Composition-based stats. Identities = 46/213 (21%), Positives = 88/213 (41%), Gaps = 18/213 (8%) Query: 157 TGKNQVTATKADGGTQVIDTKNILIATGSE--VTPFPGITIDEDTIVSSTGALSLKK--- 211 T + DG T + I+IATGS PG + + + G + + + Sbjct: 83 LDVQTRTISLDDGTT--LSADAIVIATGSRARTMALPGSQLPGVVTLRTYGDVQVLRDSW 140 Query: 212 -VPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGF 270 +++++G G+IG E+ + ++LG VT +E + + I + +L + G Sbjct: 141 TSATRLLIVGGGLIGCEVATTARKLGLSVTILEAGDELLVRVLGRRIGAWLRGLLTELGV 200 Query: 271 KFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIE 330 + +L T V G + + +E D L+C+G P + + G+ Sbjct: 201 QVELGTGVVGFSGEGQ------LEQVMASDGRSFVADSALICVGAEPADQL--ARQAGLA 252 Query: 331 LDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLA 363 D + V+ T ++A+GDV + P+ A Sbjct: 253 CDR--GVIVDHCGATLAKGVFAVGDVASWPLRA 283 Score = 30.7 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 24/147 (16%), Positives = 40/147 (27%), Gaps = 23/147 (15%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNF------------- 261 + +IG GV G + G + +SK Sbjct: 4 HVAIIGNGVGGFTTAQALRAEGFEGRISLIGDEPHLPYDRPSLSKAVLDGSLERPPILAE 63 Query: 262 QRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKN 321 + +VT +DV S ++ D +++ G R T Sbjct: 64 ADWYGEARIDMLTGPEVTA--------LDVQTRTISLDDGTTLSADAIVIATGSRARTMA 115 Query: 322 L-GLEELG-IELDPRGRIPVNTRFQTK 346 L G + G + L G + V T Sbjct: 116 LPGSQLPGVVTLRTYGDVQVLRDSWTS 142 >6BWT-A nrPDB Length = 319 Score = 117 bits (293), Expect = 1e-26, Method: Composition-based stats. Identities = 63/329 (19%), Positives = 99/329 (30%), Gaps = 58/329 (17%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHG 103 + ++GSGP GY AAI AA+ K V I + GG + + Sbjct: 10 LIILGSGPAGYTAAIYAARANLKPVIITGMQP-GGQLTTTTDV---------------YN 53 Query: 104 KDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVT 163 GI E+ L K E+ T + + N V N K+ Sbjct: 54 WPGEPDGIMGPELMEKLQKQAERFDTQI-----VYDTI---NAVDLQNKPFKLV------ 99 Query: 164 ATKADGGTQVIDTKNILIATGSEVTPFPGITIDE-------DTIVSSTGALSLKKVPEKM 216 G + ++IATG+ + G+ +E + G + + Sbjct: 100 -----GEVEQYTCDTLIIATGA-TAKYLGLESEEKFMGKGVSACATCDGFFYKN---KDV 150 Query: 217 VVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNT 276 V+G G VE + VT + + I + Q NT Sbjct: 151 AVVGGGNTAVEEALFLSNIAKSVTLIHRRDTLRSEKI---LIDKLMEKAQHGNINIIWNT 207 Query: 277 KVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGR 336 + G + I+ + + + + IG P T G G Sbjct: 208 TLEEVLGDDMGVNALRIKNIKTNEESQMGVAGVFIAIGHTPNTSIF----AGQLEMENGY 263 Query: 337 IPVN-----TRFQTKIPNIYAIGDVVAGP 360 I V QT I ++A GDV Sbjct: 264 IKVKSGLAGDATQTNIKGVFAAGDVADHV 292 >1F6M-A nrPDB Length = 320 Score = 116 bits (291), Expect = 2e-26, Method: Composition-based stats. Identities = 61/329 (18%), Positives = 103/329 (31%), Gaps = 57/329 (17%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHG 103 + ++GSGP GY AA+ AA+ + V I + Sbjct: 8 LLILGSGPAGYTAAVYAARANLQPVLITG------------------MEKGGQLTTTTEV 49 Query: 104 KDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVT 163 +++ +++ L +++M E + + NKV N ++ G N Sbjct: 50 ENWPGDPNDLTGPLL-MERMHEHATKFETEIIFDHI-----NKVDLQNRPFRLNGDNG-- 101 Query: 164 ATKADGGTQVIDTKNILIATGS--EVTPFPGITIDEDTIV----SSTGALSLKKVPEKMV 217 ++IATG+ P + V + G +K+ Sbjct: 102 ---------EYTCDALIIATGASARYLGLPSEEAFKGRGVSASATCDGFFYRN---QKVA 149 Query: 218 VIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTK 277 VIG G VE + ++V + I + K ++ N Sbjct: 150 VIGGGNTAVEEALYLSNIASEVHLIHRRDGFRAEKI---LIKRLMDKVENGNIILHTNRT 206 Query: 278 VTGATKKSDGKIDVSIEAA-SGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGR 336 + T G V + + E + L V IG P T G G Sbjct: 207 LEEVTGDQMGVTGVRLRDTQNSDNIESLDVAGLFVAIGHSPNTAIFE----GQLELENGY 262 Query: 337 IPVNT-----RFQTKIPNIYAIGDVVAGP 360 I V + QT IP ++A GDV+ Sbjct: 263 IKVQSGIHGNATQTSIPGVFAAGDVMDHI 291 >5U63-A nrPDB Length = 321 Score = 115 bits (289), Expect = 3e-26, Method: Composition-based stats. Identities = 58/328 (17%), Positives = 107/328 (32%), Gaps = 58/328 (17%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHG 103 + ++GSGP GY AAI AA+ K V + L Sbjct: 12 LLILGSGPAGYTAAIYAARANLKPVLVTG------------------LQQGGQLTTTDEI 53 Query: 104 KDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVT 163 +++ EM+ + +M++ + N+V + K+ G Sbjct: 54 ENWPG-DFEMTTGSGLMQRMLQHAEKFETEIVFDHI-----NRVDLSSRPFKLFGD---- 103 Query: 164 ATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDT-------IVSSTGALSLKKVPEKM 216 Q ++IATG+ G+ +E+ + G K + Sbjct: 104 -------VQNFTCDALIIATGASARYI-GLPSEENYKGRGVSACATCDGFFYRNKP---V 152 Query: 217 VVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNT 276 VIG G VE + + V + I + + +++ + Sbjct: 153 GVIGGGNTAVEEALYLANIASTVHLIHRRDSFRAEKI---LIDRLYKKVEEGKIVLHTDR 209 Query: 277 KVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGR 336 + + G + + G+ E + D L V IG P T+ + +EL+ G Sbjct: 210 TLDEVLGDNMGVTGLRLANTKTGEKEELKLDGLFVAIGHSPNTEIFQGQ---LELN-NGY 265 Query: 337 IPVNTRF-----QTKIPNIYAIGDVVAG 359 I V + T + ++A GDV+ Sbjct: 266 IVVKSGLDGNATATSVEGVFAAGDVMDH 293 >4YRY-B nrPDB Length = 468 Score = 112 bits (281), Expect = 3e-25, Method: Composition-based stats. Identities = 72/366 (19%), Positives = 122/366 (33%), Gaps = 89/366 (24%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHG 103 V V+GSGP G AA A++G+ E GG + Sbjct: 143 VAVVGSGPAGLTAAADLAKMGYHVDIFEAFHKPGGVLV---------------------- 180 Query: 104 KDFASRGIEMSEVRLNLDK-MMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQV 162 GI L K ++E++ + ++ L G+ N V Sbjct: 181 -----YGI----PEFRLPKRIVEREVSYIRKL--GVNFHL-----------------NTV 212 Query: 163 TATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGAL--------------- 207 + + + I TG+ F GI V S Sbjct: 213 VGKTVKVKELLSEYDAVFIGTGAGTPKFMGIPGTNLNGVYSANEFLTRVNLMKAYLFPEY 272 Query: 208 -SLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQ 266 + +V +K+ VIGAG ++ RLGA+ + + + + L+ Sbjct: 273 DTPIRVGKKVAVIGAGNTAMDAARSALRLGAEKVYIVYRRT---EREMPARREEYHHALE 329 Query: 267 KQGFKFKLNTKVTGATKKSDGKID----VSIEAASG------------GKAEVITCDVLL 310 + G +F T ++G ++ V +E G V+ D+++ Sbjct: 330 E-GIEFLWLTLPIRYIGDANGNVEAMECVRMELKEADGSGRPRPVPIEGSNFVLEVDMVI 388 Query: 311 VCIGRRPFTKNLGLEELGIELDPRGRIPVNTRF-QTKIPNIYAIGDVVAGPMLAHKAEDE 369 IG+ P + L E G+EL+ RG I + T + ++A GD+V G KA Sbjct: 389 EAIGQGPN-RVLLSEFPGLELNERGYIKADEDTGATSVKGVFAGGDIVTGAATVIKAMGA 447 Query: 370 GIICVE 375 G + Sbjct: 448 GKKAAQ 453 Score = 44.9 bits (105), Expect = 7e-05, Method: Composition-based stats. Identities = 21/109 (19%), Positives = 36/109 (33%), Gaps = 23/109 (21%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGH--------VGGVGIDMEISKNFQRIL 265 EK+ V+G+G G+ + ++G V E + + I + + Sbjct: 141 EKVAVVGSGPAGLTAAADLAKMGYHVDIFEAFHKPGGVLVYGIPEFRLPKRIVEREVSYI 200 Query: 266 QKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIG 314 +K G F LNT V K K + D + + G Sbjct: 201 RKLGVNFHLNTVVGKTVKV---------------KELLSEYDAVFIGTG 234 >5JFC-L nrPDB Length = 474 Score = 111 bits (277), Expect = 9e-25, Method: Composition-based stats. Identities = 64/366 (17%), Positives = 118/366 (32%), Gaps = 88/366 (24%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHG 103 V +IG+GP G A A++G++ E GG + Sbjct: 157 VAIIGAGPAGLTCAADLAKMGYEVTIYEALHQPGGVLI---------------------- 194 Query: 104 KDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVT 163 GI L K + +K ++ V N + Sbjct: 195 -----YGI----PEFRLPKEIVKKELE----------NLRRLGVKIET--------NVLV 227 Query: 164 ATKADGGTQVIDTKNILIATGSEVTPF---PGITIDEDT----IVSSTGALSLKKVP--- 213 + I I TG+ PG+ ++ ++ + K P Sbjct: 228 GKTITFEELREEYDAIFIGTGAGTPRIYPWPGVNLNGIYSANEFLTRINLMKAYKFPEYD 287 Query: 214 ------EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQK 267 +++ VIG G ++ RLGA+V + +M + + ++ Sbjct: 288 TPIKVGKRVAVIGGGNTAMDAARSALRLGAEVWILYRRTRK-----EMTAREEEIKHAEE 342 Query: 268 QGFKFKLNTKVTGATKKSDGKID-VSIEAAS--------------GGKAEVITCDVLLVC 312 +G KF +G + + +E G+ ++ D ++ Sbjct: 343 EGVKFMFLVTPKRFIGDENGNLKAIELEKMKLGEPDESGRRRPIPTGETFIMEFDTAIIA 402 Query: 313 IGRRPFTKNLGLEEL-GIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGI 371 IG+ P LE + G+++D GRI V+ T IP ++A GD + G A +G Sbjct: 403 IGQTPN--KTFLETVPGLKVDEWGRIVVDENLMTSIPGVFAGGDAIRGEATVILAMGDGR 460 Query: 372 ICVEGM 377 + + Sbjct: 461 KAAKAI 466 Score = 47.6 bits (112), Expect = 1e-05, Method: Composition-based stats. Identities = 22/107 (20%), Positives = 40/107 (37%), Gaps = 10/107 (9%) Query: 209 LKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGH--------VGGVGIDMEISKN 260 +K+ +K+ +IGAG G+ + ++G +VT E L + + EI K Sbjct: 150 IKRNGKKVAIIGAGPAGLTCAADLAKMGYEVTIYEALHQPGGVLIYGIPEFRLPKEIVKK 209 Query: 261 FQRILQKQGFKFKLNTKVTGATKKSD--GKIDVSIEAASGGKAEVIT 305 L++ G K + N V + + D G + Sbjct: 210 ELENLRRLGVKIETNVLVGKTITFEELREEYDAIFIGTGAGTPRIYP 256 >5W4C-A nrPDB Length = 371 Score = 110 bits (275), Expect = 2e-24, Method: Composition-based stats. Identities = 66/324 (20%), Positives = 111/324 (34%), Gaps = 50/324 (15%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHG 103 V +IGSGPGG+ AAI A+ + V E G Sbjct: 33 VVIIGSGPGGHTAAIYLARANLEPVLYEGMLANG-------------FAPGGQLTTTTDV 79 Query: 104 KDFASR--GIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQ 161 ++F G+ +E+ +DK Q + V V+ + + Sbjct: 80 ENFPGFPEGVTGTEM---MDKFRAQSERFGTKIIT--------ETVARVDLSVR---PFK 125 Query: 162 VTATKADGGTQVIDTKNILIATGSEVTPF--PGITIDEDTIVS----STGALSLKKVPEK 215 + + + I++ATG+ PG + +S GA+ + + + Sbjct: 126 YWTEGEEEEHEFMTADTIILATGASAKRLFLPGEETYWQSGISACAVCDGAVPIFRQ-KP 184 Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 + VIG G E + + G+ V + + SK + L K + Sbjct: 185 LAVIGGGDSAAEEATYLTKYGSHVYVLVRRDELRA-------SKIMAKRLTSH-PKVTVL 236 Query: 276 TKVTGATKKSDGKIDVSIEAASGGKAEV--ITCDVLLVCIGRRPFTKNLGLEELGIELDP 333 K DG++ S+ + E + + L IG P T L + +ELD Sbjct: 237 WNTVATEAKGDGEVLTSLTIKNTKTGETGDLPVNGLFYAIGHEPATS---LVKSQVELDS 293 Query: 334 RGRIP-VNTRFQTKIPNIYAIGDV 356 G I V QT + ++A GDV Sbjct: 294 DGYIKTVPGTSQTSVHGVFAAGDV 317 >5USX-A nrPDB Length = 319 Score = 109 bits (272), Expect = 3e-24, Method: Composition-based stats. Identities = 51/328 (15%), Positives = 90/328 (27%), Gaps = 58/328 (17%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHG 103 + ++GSGP GY AA+ AA+ V I + Sbjct: 9 LLILGSGPAGYTAAVYAARANLNPVLITG------------------MQQGGQLTTTTEV 50 Query: 104 KDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVT 163 ++ L +M++ + I + Sbjct: 51 EN-----WPGDPEGLTGPGLMDRMKEHAERFETEIIF---DHINEVDFSTRPFV------ 96 Query: 164 ATKADGGTQVIDTKNILIATGSEVTPFPGITIDE-------DTIVSSTGALSLKKVPEKM 216 G ++I+TG+ G+ +E + G +K+ Sbjct: 97 ---LKGDAASYSCDALIISTGASAKYL-GLESEEAFKGRGVSACATCDGFFYRN---QKV 149 Query: 217 VVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNT 276 V+G G VE + A+V + I + +Q + Sbjct: 150 AVVGGGNTAVEEALYLSNIAAEVHLIHRRDSFRAEKI---LINRLMDKVQNGNIVLHTDR 206 Query: 277 KVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGR 336 + G V ++ G E + + IG P T+ G G Sbjct: 207 VLDEVLGDEMGVTGVRLKDVKTGGTEELDVMGAFIAIGHSPNTQIFQ----GQLDMKDGY 262 Query: 337 IPVNTRF-----QTKIPNIYAIGDVVAG 359 I V + QT + I+A GDV+ Sbjct: 263 ILVKSGLEGNATQTSVEGIFAAGDVMDH 290 >4FX9-A nrPDB Length = 453 Score = 109 bits (272), Expect = 4e-24, Method: Composition-based stats. Identities = 69/389 (17%), Positives = 130/389 (33%), Gaps = 88/389 (22%) Query: 139 AHLFKQNKVV-HVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDE 197 K+ + H+N V + +GG + + ++ A G+ P I Sbjct: 69 EVFIKKRGIDLHLNAEVIEVDTGYVRVRE-NGGEKSYEWDYLVFANGASP-QVPAIEGVN 126 Query: 198 DTIVSSTG----ALSLKKVPEK-----MVVIGAGVIGVELGSVWQRLGADVTA------- 241 V + AL++++ EK +V+IG G IG+E+ + G +VT Sbjct: 127 LKGVFTADLPPDALAIREYMEKYKVENVVIIGGGYIGIEMAEAFAAQGKNVTMIVRGERV 186 Query: 242 --------------------VEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGA 281 V Sbjct: 187 LRRSFDKEVTDILEEKLKKHVNLRLQ--------------------------------EI 214 Query: 282 TKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNT 341 T K +G+ V G+ +++++ G +P + ++LG+ + G I N Sbjct: 215 TMKIEGEERVEKVVTDAGE---YKAELVILATGIKPNIEL--AKQLGVRIGETGAIWTNE 269 Query: 342 RFQTKIPNIYAIGDVVA----------GPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPS 391 + QT + N+YA GDV LA G + +AG +H + Sbjct: 270 KMQTSVENVYAAGDVAETRHVITGRRVWVPLAPAGNKMGYVAGSNIAGKELHFPGVLGTA 329 Query: 392 VI-YTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRV 450 V + E+ G +E + +EG + + + + +K + T+R+ Sbjct: 330 VTKFMDVEIGKTGLTEMEALKEGYDVRTAFIKASTRPHYYPGGR-EIWLKGVVDNETNRL 388 Query: 451 LGAHILGPGAGEMVNEAALALEYGASCED 479 LG ++G ++ AA L G + +D Sbjct: 389 LGVQVVGSDILPRIDTAAAMLMAGFTTKD 417 >3D8X-A nrPDB Length = 326 Score = 108 bits (271), Expect = 4e-24, Method: Composition-based stats. Identities = 68/324 (20%), Positives = 117/324 (36%), Gaps = 51/324 (15%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHG 103 VT+IGSGP + AAI A+ K + E G + Sbjct: 13 VTIIGSGPAAHTAAIYLARAEIKPILYEGMMANG-------------IAAGGQLTTTTEI 59 Query: 104 KDFASR--GIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQ 161 ++F G+ SE+ +D+M EQ + F + ++ K Sbjct: 60 ENFPGFPDGLTGSEL---MDRMREQSTK------------FGTEIITETVSKVDLSSKPF 104 Query: 162 VTATKADGGTQVIDTKNILIATGS--EVTPFPGITIDEDTIVS----STGALSLKKVPEK 215 T+ + + + T I++ATG+ + PG +S GA+ + + + Sbjct: 105 KLWTEFNEDAEPVTTDAIILATGASAKRMHLPGEETYWQKGISACAVCDGAVPIFRN-KP 163 Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 + VIG G E + G+ V + H+ I + ++ ++ + N Sbjct: 164 LAVIGGGDSACEEAQFLTKYGSKVFMLVRKDHLRASTIMQKRAEKNEK------IEILYN 217 Query: 276 TKVTGATKKSDGKIDVSIEAASGGKAEV--ITCDVLLVCIGRRPFTKNLGLEELGIELDP 333 T K DGK+ ++ + K E + L IG P TK + ++ D Sbjct: 218 T--VALEAKGDGKLLNALRIKNTKKNEETDLPVSGLFYAIGHTPATK---IVAGQVDTDE 272 Query: 334 RGRIP-VNTRFQTKIPNIYAIGDV 356 G I V T +P +A GDV Sbjct: 273 AGYIKTVPGSSLTSVPGFFAAGDV 296 >5VJ7-A nrPDB Length = 476 Score = 106 bits (264), Expect = 3e-23, Method: Composition-based stats. Identities = 73/366 (19%), Positives = 118/366 (32%), Gaps = 87/366 (23%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHG 103 V +IG+GP G A A++G++ E GG Sbjct: 157 VAIIGAGPAGLTCAADLAKMGYEVTIYEALHQPGGV------------------------ 192 Query: 104 KDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVT 163 + L K + +K +L G + K H+ G +T Sbjct: 193 -------LTYGIPEFRLPKEILRKELKKLSLLGV------EIKTDHIVG-------KTIT 232 Query: 164 ATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGAL-------SLKKVPE-- 214 + + + + I TG+ P I + S K PE Sbjct: 233 IQEL-----LQEYDAVFIGTGAGTPKLPNIPGINLNGIYSANEFLTRINLMKAYKFPEYD 287 Query: 215 -------KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQK 267 K+VVIGAG ++ RLGA+VT G DM + ++ Sbjct: 288 TPIVVGKKVVVIGAGNTAMDAARSALRLGAEVTIAYRRGR-----EDMTARIEEVKHAEE 342 Query: 268 QGFKFKLNTKVTGATKKSDGKID-VSIEAAS---------------GGKAEVITCDVLLV 311 +G KF +G + V E G+ + D +++ Sbjct: 343 EGVKFMFFVNPVEFIGDENGNVKAVKFEKMKPLEERDSRGKRKIVGTGEYITVEADTVII 402 Query: 312 CIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGI 371 IG+ P K L +++D GRI V+ T IP ++A GD + G A +G Sbjct: 403 AIGQTPN-KVLWRATPELKVDEWGRIVVDENLMTSIPGVFAGGDAIRGEATVILAMGDGR 461 Query: 372 ICVEGM 377 + + Sbjct: 462 KAAKAI 467 Score = 46.1 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 22/128 (17%), Positives = 44/128 (34%), Gaps = 27/128 (21%) Query: 209 LKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGH--------VGGVGIDMEISKN 260 +K+ +K+ +IGAG G+ + ++G +VT E L + + EI + Sbjct: 150 IKRNGKKVAIIGAGPAGLTCAADLAKMGYEVTIYEALHQPGGVLTYGIPEFRLPKEILRK 209 Query: 261 FQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIG----RR 316 + L G + K + V + + D + + G + Sbjct: 210 ELKKLSLLGVEIKTDHIVGKTITI---------------QELLQEYDAVFIGTGAGTPKL 254 Query: 317 PFTKNLGL 324 P + L Sbjct: 255 PNIPGINL 262 >6BPY-A nrPDB Length = 374 Score = 105 bits (261), Expect = 6e-23, Method: Composition-based stats. Identities = 68/333 (20%), Positives = 113/333 (33%), Gaps = 53/333 (15%) Query: 39 PIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYY 98 + V +IGSGP + AAI ++ K V E G Sbjct: 2 MVHTKVVIIGSGPAAHTAAIYLSRAELKPVLYEGMLANGTA-------------AGGQLT 48 Query: 99 HMAHGKDFASR--GIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKI 156 ++F GI +E+ N+ K +++ G + + V+ K Sbjct: 49 TTTDIENFPGFPDGIGGAELMENMRK---------QSIRFGTEVI--TETISRVDLSSK- 96 Query: 157 TGKNQVTATKADG--GTQVIDTKNILIATGS--EVTPFPGITIDEDTIVS----STGALS 208 ++ DG ++IATG+ PG +S GA+ Sbjct: 97 --PFKLWTEWNDGPDKEPACTADAVIIATGANARRLNLPGEETYWQNGISACAVCDGAVP 154 Query: 209 LKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQ 268 + + + + VIG G E + G+ VT + + SK + L Sbjct: 155 IFRN-KPLYVIGGGDSAAEEAMFLAKYGSSVTVLVRRDKLRA-------SKAMAKRLLAH 206 Query: 269 -GFKFKLNTKVTGA--TKKSDG-KIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGL 324 + NT T KK +G + I+ G+ E++ + L +G P T L Sbjct: 207 PKVTVRFNTVATEVLGEKKPNGLMTHLRIKNTVTGEEEIVDANGLFYAVGHDPATA---L 263 Query: 325 EELGIELDPRGRIPVN-TRFQTKIPNIYAIGDV 356 + I+LD G I T ++A GDV Sbjct: 264 VKGQIDLDEDGYIITKPGTSYTSREGVFACGDV 296 >4CBQ-A nrPDB Length = 314 Score = 104 bits (260), Expect = 8e-23, Method: Composition-based stats. Identities = 61/341 (17%), Positives = 110/341 (32%), Gaps = 51/341 (14%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 102 DV +IGSGP + AAI + K V E GG Sbjct: 6 DVVIIGSGPAAHTAAIYLGRSSLKPVMYEGFMA-GGVA------------AGGQLTTTTI 52 Query: 103 GKDFASR--GIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKN 160 ++F GI+ +E+ +N + ++ + + Sbjct: 53 IENFPGFPNGIDGNELMMN------------------MRTQSEKYGTTIITETIDHVDFS 94 Query: 161 QVTATKADGGTQVIDTKNILIATG--SEVTPFPGI----TIDEDTIVSSTGALSLKKVPE 214 + + TK+++IATG ++ PG GA+ + + + Sbjct: 95 TQPFKLFTEEGKEVLTKSVIIATGATAKRMHVPGEDKYWQNGVSACAICDGAVPIFRN-K 153 Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL 274 ++V+G G +E + G+ V + E R+L + Sbjct: 154 VLMVVGGGDAAMEEALHLTKYGSKVIILHRRDAFRASKTMQE------RVLNHPKIEVIW 207 Query: 275 NTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPR 334 N+++ D I G+ +V+ L IG P +K LG + ++ Sbjct: 208 NSELVELEGDGDLLNGAKIHNLVSGEYKVVPVAGLFYAIGHSPNSKFLGGQ---VKTADD 264 Query: 335 GRIPVNTRFQTKIPNIYAIGDVVAGPML-AHKAEDEGIICV 374 G I +T + ++A GDV A A G + Sbjct: 265 GYILT-EGPKTSVDGVFACGDVCDRVYRQAIVAAGSGCMAA 304 >3ISH-A nrPDB Length = 311 Score = 104 bits (259), Expect = 1e-22, Method: Composition-based stats. Identities = 59/345 (17%), Positives = 112/345 (32%), Gaps = 59/345 (17%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 102 D +IG GP G A + A + G K + + GG + Sbjct: 3 DCAIIGGGPAGLSAGLYATRGGVKNAVLFEKGMPGG-----------------QITGSSE 45 Query: 103 GKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQV 162 +++ + EV LD M + K +++ V K + V Sbjct: 46 IENYPG----VKEVVSGLDFMQPWQEQC-------FRFGLK-HEMTAVQRVSK-KDSHFV 92 Query: 163 TATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDT-------IVSSTGALSLKKVPEK 215 + + + K+++IATG GI + + + G ++ Sbjct: 93 ILAED---GKTFEAKSVIIATGGSPKR-TGIKGESEYWGKGVSTCATCDGFFYKN---KE 145 Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 + V+G G VE + V + I +E +KN + +F Sbjct: 146 VAVLGGGDTAVEEAIYLANICKKVYLIHRRDGFRCAPITLEHAKNNDK------IEFLTP 199 Query: 276 TKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGI--ELDP 333 V + G +SI+ + + + + +G L E+ + + D Sbjct: 200 YVVEEIKGDASGVSSLSIKNTATNEKRELVVPGFFIFVGYDVNNAVLKQEDNSMLCKCDE 259 Query: 334 RGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHK----AEDEGIICV 374 G I V+ +T + ++A GD+ + A K A +G Sbjct: 260 YGSIVVDFSMKTNVQGLFAAGDI---RIFAPKQVVCAASDGATAA 301 >1XHC-A nrPDB Length = 367 Score = 103 bits (256), Expect = 3e-22, Method: Composition-based stats. Identities = 65/381 (17%), Positives = 139/381 (36%), Gaps = 77/381 (20%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIP--SKALLNNSHYYHMA 101 V ++G+GPGG+ A + +Q ++ I+K +P SK +L++ + Sbjct: 11 VVIVGNGPGGFELAKQLSQT-YEVTVIDKEP-----------VPYYSKPMLSHYIAGFIP 58 Query: 102 HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVH-VNGYGKITGKN 160 + F L+ +++ + + K+ + Sbjct: 59 RNRLFPY--------SLDW---------------------YRKRGIEIRLAEEAKLIDRG 89 Query: 161 QVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIG 220 + G + +++ATG+ P I ++ +++ ++ E + G Sbjct: 90 RKVVITEKGE---VPYDTLVLATGARARE-PQIKG-KEYLLTLRTIFDADRIKESIENSG 144 Query: 221 ------AGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL 274 G IG+EL G V + +G+D E+S + +L++ G KF L Sbjct: 145 EAIIIGGGFIGLELAGNLAEAGYHVKLIH--RGAMFLGLDEELSNMIKDMLEETGVKFFL 202 Query: 275 NTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPR 334 N+++ +G + + I V + IG P GI Sbjct: 203 NSELL--EANEEGVLT---------NSGFIEGKVKICAIGIVPNVDL--ARRSGIHTGR- 248 Query: 335 GRIPVNTRFQTKIPNIYAIGDVVAGPML----AHKAEDEGIICVEGMAGGAVHIDYNCVP 390 I ++ F+T ++YAIGD + A A ++ + + + G ++ Sbjct: 249 -GILIDDNFRTSAKDVYAIGDCAEYSGIIAGTAKAAMEQARVLADILKGEPRRYNFKFRS 307 Query: 391 SVI-YTHPEVAWVGKSEEQLK 410 +V + ++A +G ++ + K Sbjct: 308 TVFKFGKLQIAIIGNTKGEGK 328 Score = 34.9 bits (79), Expect = 0.096, Method: Composition-based stats. Identities = 23/124 (18%), Positives = 39/124 (31%), Gaps = 28/124 (22%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQ----------- 262 K+V++G G G EL + +VT ++ +S Sbjct: 9 SKVVIVGNGPGGFELAKQLSQT-YEVTVID--KEPVPYYSKPMLSHYIAGFIPRNRLFPY 65 Query: 263 --RILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIG---RRP 317 +K+G + +L K D V I + + D L++ G R P Sbjct: 66 SLDWYRKRGIEIRL----AEEAKLIDRGRKVVIT-----EKGEVPYDTLVLATGARAREP 116 Query: 318 FTKN 321 K Sbjct: 117 QIKG 120 >3AB1-A nrPDB Length = 360 Score = 99.2 bits (246), Expect = 3e-21, Method: Composition-based stats. Identities = 64/331 (19%), Positives = 112/331 (33%), Gaps = 44/331 (13%) Query: 37 DQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSH 96 D D+T+IG GP G AA + IE LGG + Sbjct: 10 DHHDMRDLTIIGGGPTGIFAAFQCGMNNISCRIIESMPQLGG--------------QLAA 55 Query: 97 YYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKI 156 Y H D A ++ ++E + + K + Sbjct: 56 LYPEKHIYDVAGFP---EVPAID---LVESLWAQAERYNPDVVLNETVTKYTKL------ 103 Query: 157 TGKNQVTATKADGGTQVIDTKNILIATGS---EVTPFPGITIDEDTIVSSTGALSLKKV- 212 G V ++ +LIA G E P + + D + S+ ++K V Sbjct: 104 -DDGTFETRTNTGN--VYRSRAVLIAAGLGAFEPRKLPQL-GNIDHLTGSSVYYAVKSVE 159 Query: 213 ---PEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQG 269 +++V++G G ++ + A VT V G G + + +R Sbjct: 160 DFKGKRVVIVGGGDSALDWTVGLIKNAASVTLVHRGHEFQGHG---KTAHEVERARANGT 216 Query: 270 FKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGI 329 L T+V + + V + ++ G K + D LL+ IG + L + Sbjct: 217 IDVYLETEVASIEESNGVLTRVHLRSSDGSKW-TVEADRLLILIGFKSNLGP--LARWDL 273 Query: 330 ELDPRGRIPVNTRFQTKIPNIYAIGDVVAGP 360 EL + V++ +T + +YA GD+ P Sbjct: 274 ELYEN-ALVVDSHMKTSVDGLYAAGDIAYYP 303 >4YKF-A nrPDB Length = 521 Score = 98.5 bits (244), Expect = 7e-21, Method: Composition-based stats. Identities = 45/220 (20%), Positives = 75/220 (34%), Gaps = 17/220 (7%) Query: 170 GTQVIDTKNILIATGS--EVTPFPGITIDEDTIVSSTGALSLK-KVPEKMVVIGAGVIGV 226 V+ ++I++ATG+ PG V+ +++ VIG G GV Sbjct: 309 SGAVLKARSIIVATGAKWRNMNVPGEDQYRTKGVTYCPHCDGPLFKGKRVAVIGGGNSGV 368 Query: 227 ELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSD 286 E + VT +EF + D + + + + LN + T Sbjct: 369 EAAIDLAGIVEHVTLLEFAPEMKA---DQVLQDKLRSL---KNVDIILNAQTTEVKGDGS 422 Query: 287 GKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTK 346 + + G I + V IG P T L E +E + G I ++ + +T Sbjct: 423 KVVGLEYRDRVSGDIHNIELAGIFVQIGLLPNTNWL---EGAVERNRMGEIIIDAKCETN 479 Query: 347 IPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDY 386 + ++A GD P G EG DY Sbjct: 480 VKGVFAAGDCTTVP-YKQIIIATG----EGAKASLSAFDY 514 >1FL2-A nrPDB Length = 310 Score = 95.0 bits (235), Expect = 7e-20, Method: Composition-based stats. Identities = 39/194 (20%), Positives = 70/194 (36%), Gaps = 12/194 (6%) Query: 170 GTQVIDTKNILIATGS--EVTPFPGITIDEDTIVSSTGALSLK-KVPEKMVVIGAGVIGV 226 V+ ++I++ATG+ PG V+ +++ VIG G GV Sbjct: 98 SGAVLKARSIIVATGAKWRNMNVPGEDQYRTKGVTYCPHCDGPLFKGKRVAVIGGGNSGV 157 Query: 227 ELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSD 286 E + VT +EF + + + ++ + LN + T Sbjct: 158 EAAIDLAGIVEHVTLLEFAPEMKADQVLQDKLRSL------KNVDIILNAQTTEVKGDGS 211 Query: 287 GKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTK 346 + + G I + V IG P T L E +E + G I ++ + +T Sbjct: 212 KVVGLEYRDRVSGDIHNIELAGIFVQIGLLPNTNWL---EGAVERNRMGEIIIDAKCETN 268 Query: 347 IPNIYAIGDVVAGP 360 + ++A GD P Sbjct: 269 VKGVFAAGDCTTVP 282 >3R9U-A nrPDB Length = 315 Score = 93.8 bits (232), Expect = 1e-19, Method: Composition-based stats. Identities = 53/323 (16%), Positives = 102/323 (31%), Gaps = 52/323 (16%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFK-TVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMA 101 DV +IG GP G A + A + G K V EK + G I S + + N Sbjct: 6 DVAIIGGGPAGLSAGLYATRGGLKNVVMFEKG-------MPGGQITSSSEIENYPGVAQV 58 Query: 102 HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQ 161 +R L M G+ + K + G T Sbjct: 59 MDGISFMAPWSEQCMRFGLKHEMV-----------GVEQILKNSD-------GSFT---- 96 Query: 162 VTATKADGGTQVIDTKNILIATGSEVTPFPGITIDE------DTIVSSTGALSLKKVPEK 215 K +GG + K +++ TGS DE T + G ++ Sbjct: 97 ---IKLEGGKTEL-AKAVIVCTGSAPKKAGFKGEDEFFGKGVSTCATCDGFFYKN---KE 149 Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 + V+G G +E + + + + +++ + + + + Sbjct: 150 VAVLGGGDTALEEALYLANICSKIYLIHRRDEFRAAP------STVEKVKKNEKIELITS 203 Query: 276 TKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELD--P 333 V G V ++ G + + +G + L ++ + Sbjct: 204 ASVDEVYGDKMGVAGVKVKL-KDGSIRDLNVPGIFTFVGLNVRNEILKQDDSKFLCNMEE 262 Query: 334 RGRIPVNTRFQTKIPNIYAIGDV 356 G++ V+ + QT + ++A GD+ Sbjct: 263 GGQVSVDLKMQTSVAGLFAAGDL 285 >1VDC-A nrPDB Length = 333 Score = 92.7 bits (229), Expect = 3e-19, Method: Composition-based stats. Identities = 47/220 (21%), Positives = 77/220 (35%), Gaps = 28/220 (12%) Query: 171 TQVIDTKNILIATGSEVTPFPGITIDE------DTIVS----STGALSLKKVPEKMVVIG 220 ++ I +++A G+ + E + +S GA + + + + VIG Sbjct: 108 SKAILADAVILAIGAVAKRLSFVGSGEVLGGFWNRGISACAVCDGAAPIFRN-KPLAVIG 166 Query: 221 AGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTG 280 G +E + + G+ V + I QR L N+ V Sbjct: 167 GGDSAMEEANFLTKYGSKVYIIHRRDAFRASKIMQ------QRALSNPKIDVIWNSSV-- 218 Query: 281 ATKKSDGKIDV----SIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGR 336 DG+ DV ++ G + L IG P TK L + G+ELD G Sbjct: 219 VEAYGDGERDVLGGLKVKNVVTGDVSDLKVSGLFFAIGHEPATKFL---DGGVELDSDGY 275 Query: 337 IPVN-TRFQTKIPNIYAIGDVVAGPML-AHKAEDEGIICV 374 + QT +P ++A GDV A A G + Sbjct: 276 VVTKPGTTQTSVPGVFAAGDVQDKKYRQAITAAGTGCMAA 315 >2ZBW-A nrPDB Length = 335 Score = 92.3 bits (228), Expect = 5e-19, Method: Composition-based stats. Identities = 52/331 (15%), Positives = 96/331 (29%), Gaps = 42/331 (12%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMA 101 DV ++G+GP G A G ++ GG + Y Sbjct: 6 TDVLIVGAGPTGLFAGFYVGMRGLSFRFVDPLPEPGG--------------QLTALYPEK 51 Query: 102 HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQ 161 + D A K+ + + G + + N V + + + Sbjct: 52 YIYDVAGF-----------PKVYAK-----DLVKGLVEQVAPFNPVYSLGERAETLEREG 95 Query: 162 VTATKADGGTQVIDTKNILIATGS---EVTPF--PGITIDEDTIVSSTGALSLKKVPEKM 216 K ++IA G E PG E V + +++ Sbjct: 96 DLFKVTTSQGNAYTAKAVIIAAGVGAFEPRRIGAPGEREFEGRGVYYAVKSKAEFQGKRV 155 Query: 217 VVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNT 276 +++G G V+ +T + K + ++ + Sbjct: 156 LIVGGGDSAVDWALNLLDTARRITLIHRRPQFRA---HEASVKELMKAHEEGRLEVLTPY 212 Query: 277 KVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGR 336 ++ + V + + D +L+ G TK L G+ L + + Sbjct: 213 ELRRVEGDERVRWAVVFHNQ-TQEELALEVDAVLILAGYI--TKLGPLANWGLAL-EKNK 268 Query: 337 IPVNTRFQTKIPNIYAIGDVVAGPMLAHKAE 367 I V+T T IP +YA GD+V P Sbjct: 269 IKVDTTMATSIPGVYACGDIVTYPGKLPLIV 299 >3LZX-A nrPDB Length = 332 Score = 91.9 bits (227), Expect = 5e-19, Method: Composition-based stats. Identities = 51/326 (15%), Positives = 98/326 (30%), Gaps = 48/326 (14%) Query: 37 DQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSH 96 + D+T+IG GP G A IE LGG S Sbjct: 3 EDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG--------------QLSA 48 Query: 97 YYHMAHGKDFASRG-IEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGK 155 Y + D A I E+ NL + M + + L + + KQ Sbjct: 49 LYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTI-CLEQAVESVEKQAD--------- 98 Query: 156 ITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSL-----K 210 K + +K ++I G+ + ++ K Sbjct: 99 -------GVFKLVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQK 151 Query: 211 KVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGF 270 ++ ++G G V+ + + + +V+ + ++ L Sbjct: 152 FAGRRVAILGGGDSAVDWALMLEPIAKEVSIIHRRDKFRAH-------EHSVENLHASKV 204 Query: 271 KFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIE 330 D + +E G + E++ D L+V G + + G++ Sbjct: 205 NVLTPFVPAELI-GEDKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPI--KNWGLD 261 Query: 331 LDPRGRIPVNTRFQTKIPNIYAIGDV 356 + + I V + +T I +A GD+ Sbjct: 262 I-EKNSIVVKSTMETNIEGFFAAGDI 286 >5KVH-A nrPDB Length = 543 Score = 91.5 bits (226), Expect = 8e-19, Method: Composition-based stats. Identities = 57/262 (21%), Positives = 91/262 (34%), Gaps = 38/262 (14%) Query: 152 GYGKITGKNQVTATKADG-----GTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGA 206 G +TGK V D I + LIATG I + S T Sbjct: 148 GVAVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTL 207 Query: 207 L-------SLKKVP---EKMVVIGAGVIGVELGSVW----QRLGADVTAVEFLGHVGGVG 252 SL+K+ + + +IG G +G EL + LG +V + G Sbjct: 208 FRKIGDFRSLEKISREVKSITIIGGGFLGSELACALGRKARALGTEVIQLFPEKGNMGKI 267 Query: 253 IDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVC 312 + +S ++++G K N V S GK+ + ++ + D ++ Sbjct: 268 LPEYLSNWTMEKVRREGVKVMPNAIVQSVGVSS-GKLLIKLKD-----GRKVETDHIVAA 321 Query: 313 IGRRPFTKNLGLEELGIELDPR-GRIPVNTRFQTKIPNIYAIGDVV-------AGPMLAH 364 +G P + + G+E+D G VN Q + NI+ GD + H Sbjct: 322 VGLEPNVEL--AKTGGLEIDSDFGGFRVNAELQAR-SNIWVAGDAACFYDIKLGRRRVEH 378 Query: 365 --KAEDEGIICVEGMAGGAVHI 384 A G + E M G A Sbjct: 379 HDHAVVSGRLAGENMTGAAKPY 400 >5YGQ-A nrPDB Length = 342 Score = 90.8 bits (224), Expect = 1e-18, Method: Composition-based stats. Identities = 62/337 (18%), Positives = 112/337 (33%), Gaps = 59/337 (17%) Query: 38 QPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCL------NVGCIPSKAL 91 + I DV ++G+GP G A + L K ++ + +GG C + IP + Sbjct: 3 ETIKTDVLIVGAGPCGLFAVFELGLLDVKAHLVDILDKVGGQCAELYPEKPIYDIPGIPM 62 Query: 92 LNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVN 151 + + I+ +L +M+E Sbjct: 63 VTGHGLTEALMEQ------IKPFNPTFHLSEMVENVEK---------------------- 94 Query: 152 GYGKITGKNQVTATKADGGTQVIDTKNILIATGS-----EVTPFPGITIDEDTIVSSTGA 206 G T G V + +++A G + P PG+ E T V Sbjct: 95 -----IGDPGFRVTTNAGK--VFECTVLVVAAGGGSFLPKRPPVPGVEAYEGTSVHYAVR 147 Query: 207 LSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGID-MEISKNFQRIL 265 + ++++G G ++ + +T V G ++ + Sbjct: 148 KMEDFRGKDILIVGGGDSALDWTLNLNPIAKSMTLVHRRDDFRGAPHSVEQMRQLVASG- 206 Query: 266 QKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLG-L 324 K L + +G++ + + I CD +L G T LG + Sbjct: 207 -----KLDLKIGQITELQGDNGQLTGATVKLNDNTTSQIKCDAMLPFFG---LTMKLGPV 258 Query: 325 EELGIELDPRGRIPVNT-RFQTKIPNIYAIGDVVAGP 360 G++L IPV+T F+T +P I+AIGD+ P Sbjct: 259 ANWGLDL-ENNLIPVDTGTFETNVPGIFAIGDINTYP 294 >5XHU-A nrPDB Length = 329 Score = 89.2 bits (220), Expect = 4e-18, Method: Composition-based stats. Identities = 60/323 (18%), Positives = 119/323 (36%), Gaps = 48/323 (14%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMA 101 DVT+IG GP G A KT IE LGG S ++ Sbjct: 3 YDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG--------------KVSLFFPEK 48 Query: 102 HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKV--VHVNGYGKITGK 159 +D GI + ++++ EQ A F + V V G+ ++ Sbjct: 49 IIRDIG--GIPGIAGKQLIEQLKEQ------------AATFDPDIVLNQRVTGFERL-DD 93 Query: 160 NQVTATKADGGTQVIDTKNILIATGSEVTPF-PGITIDEDTIVSSTGALSLKKVP----E 214 + T ++G T+ +++A G + D ++K+ + Sbjct: 94 GTIVLTGSEGKKHY--TRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGK 151 Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL 274 ++V+ G G V+ + + + A VT V GG + + + +++ + Sbjct: 152 RVVISGGGDTAVDWANELEPIAASVTVVHRREEFGG------MESSVTK-MKQSSVRVLT 204 Query: 275 NTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPR 334 ++ +G V++ G+ + I D L++ G + + E G+E++ Sbjct: 205 PYRLEQLNGDEEGIKSVTVCHTESGQRKDIEIDELIINHGFK--IDLGPMMEWGLEIEE- 261 Query: 335 GRIPVNTRFQTKIPNIYAIGDVV 357 GR+ + +T +P ++ GD Sbjct: 262 GRVKADRHMRTNLPGVFVAGDAA 284 >5MIU-A nrPDB Length = 535 Score = 88.1 bits (217), Expect = 8e-18, Method: Composition-based stats. Identities = 69/358 (19%), Positives = 117/358 (32%), Gaps = 60/358 (16%) Query: 57 AIKAAQLGFKTVCIEKNETLGGTCLNVGCIP------SKALLNNSHYYHMAHGKDFASRG 110 +I+A G + + + ++ L P SK L S ++ F Sbjct: 71 SIRARDPGARVLIVSEDPEL----------PYMRPPLSKELWF-SDDPNVTKTLQFRQWN 119 Query: 111 IEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGG 170 + + GG+A KVVH++ G + DG Sbjct: 120 GKERSIYFQPPSFYVSAQDLPNIENGGVAV-LTGKKVVHLDVRGNM-------VKLNDGS 171 Query: 171 TQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGAL-------SLKKVP---EKMVVIG 220 I + LIATG I + S T +L+K+ + + VIG Sbjct: 172 Q--ITFEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRALEKISREVKSITVIG 229 Query: 221 AGVIGVELGSVWQRL----GADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNT 276 G +G EL R G +V + G + +S ++++G K N Sbjct: 230 EGFLGSELACALGRKSQASGIEVIQLFPEKGNMGKILPQYLSNWTMEKVKREGVKVMPNA 289 Query: 277 KVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPR-G 335 V G++ + ++ + D ++ +G P + + G+E+D G Sbjct: 290 IVQSVGVSG-GRLLIKLKD-----GRKVETDHIVTAVGLEPNVEL--AKTGGLEIDSDFG 341 Query: 336 RIPVNTRFQTKIPNIYAIGDVV-------AGPMLAH--KAEDEGIICVEGMAGGAVHI 384 VN Q + NI+ GD + H A G + E M G A Sbjct: 342 GFRVNAELQAR-SNIWVAGDAACFYDIKLGRRRVEHHDHAVVSGRLAGENMTGAAKPY 398 >5M5J-A nrPDB Length = 325 Score = 86.9 bits (214), Expect = 2e-17, Method: Composition-based stats. Identities = 54/330 (16%), Positives = 105/330 (31%), Gaps = 48/330 (14%) Query: 51 PGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRG 110 P G A I A++ K TC+ VG + + S + ++F S Sbjct: 27 PAGLTAGIYASRANLK------------TCVFVG------IEHTSQMFTTTDVENFPSH- 67 Query: 111 IEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGG 170 + +ME + G L++ + V+ + Sbjct: 68 -----TAIKGPALMEAIQNQAE--HCGAELLYEDVHSIDVSSR-PFKIVHGYE------- 112 Query: 171 TQVIDTKNILIATGSEVTPF--PGITIDEDTIVSSTGAL-SLKKVPEKMVVIGAGVIGVE 227 + ++IATG+ G VS+ S +++VV+G G + E Sbjct: 113 NETTLADALIIATGATARRLDCKGEKEYWQKGVSACAVCDSAMATGKEVVVVGGGDVACE 172 Query: 228 LGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDG 287 + ++ V V + ++++ ++ + ++ + Sbjct: 173 EATYLTKIATKVYMVLRRDKFRAS------AAMVKKVMNEKLIEIIYDSAIDEIKGDGKC 226 Query: 288 KIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTR--FQT 345 VSI+ GK + L +G P T L++ +E D G I + +T Sbjct: 227 VTSVSIKNLKDGKTRTLNAGALYWAVGHDPQTS--FLKKGQLEQDEAGYILLKDHPTQRT 284 Query: 346 KIPNIYAIGDVVAGPML-AHKAEDEGIICV 374 + ++A GD A A G Sbjct: 285 SVDGVFAAGDCCDHLYRQAVVAAGSGSKAA 314 >6GAR-A nrPDB Length = 349 Score = 86.1 bits (212), Expect = 3e-17, Method: Composition-based stats. Identities = 73/381 (19%), Positives = 124/381 (32%), Gaps = 52/381 (13%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMA 101 DVTVIG GP G +A + +T IE + LGG ++V P K + + Sbjct: 7 FDVTVIGGGPAGLYSAFYSGLREMRTKIIEFHPHLGGK-IHV--YPEKMIWDVGGL---- 59 Query: 102 HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQ 161 + + DK++E + LT + KV I Sbjct: 60 --------------LPVTGDKLIE--QLVQQGLTFKPEVVL-DTKVE------SIIRNQD 96 Query: 162 VTATKADGGTQVIDTKNILIATGSEVTPF--PGITIDEDTIVS--STGALSLKKVPEKMV 217 T T + +K +++ATGS + I E VS + SLK+ K V Sbjct: 97 GTFTLKTSTGEEHFSKTVIVATGSGILKPQKLSIEGAERFEVSNLNYTVKSLKRFKGKTV 156 Query: 218 VI-GAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNT 276 +I G G V+ + + + V + G + + L + NT Sbjct: 157 IISGGGNSAVDWANELEPIAKKVYVTYRKEELSGH-------EAQVKQLMNSSAECFFNT 209 Query: 277 KVTGATKKSDGKI--DVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPR 334 +T + + V + G+ + D +++ G L EL + + Sbjct: 210 SITKLIAGDNHEAIEYVELTNHETGEVSHLPIDEVIINHGYERDITLLENSELDVAIIDN 269 Query: 335 GRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIY 394 I N ++ + +YA GD++ H + I + Sbjct: 270 YYIAGNANSESSVDGLYAAGDILKHEGKLHLIAGAFQDAGNAVNKAKQFIQPDAS----- 324 Query: 395 THPEVAWVGKSEEQLKEEGIE 415 E V E K+ E Sbjct: 325 ---EYGMVSSHNEVFKKRNRE 342 >4JNQ-A nrPDB Length = 345 Score = 85.4 bits (210), Expect = 6e-17, Method: Composition-based stats. Identities = 60/348 (17%), Positives = 100/348 (28%), Gaps = 66/348 (18%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHG 103 V VIGSGP GY AAI AA+ K V I + GG + + + Y G Sbjct: 29 VIVIGSGPAGYTAAIYAARAMLKPVVIAGLQQ-GGQLMITTDVENYP-----GYAEPVQG 82 Query: 104 KDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVT 163 + + +Q + V I + + T Sbjct: 83 P-------------------------------WMMEQMARQAENVGAQIVHDIITEVETT 111 Query: 164 ATK---ADGGTQVIDTKNILIATGSEVTPF------PGITIDEDTIVSSTGALSLKKVPE 214 + ++IATG++ + + G + Sbjct: 112 VRPFRLKGDSGTIYTCDALIIATGAQAKWLGLESEQTFMGGGVSACATCDGFF---YRGK 168 Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL 274 +VV+G G VE + VT V I + R+L ++ Sbjct: 169 DVVVVGGGNTAVEEALYLSHIAKSVTIVHRRDGFRAEKIMQD------RLLSRENVSVVW 222 Query: 275 NTKVTGATKKSDG------KIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELG 328 N+ + V ++ G+ + + + IG P E Sbjct: 223 NSVIDEILGTEARPPMGATVTGVRLKNIVTGETQERATHGVFIAIGHAPAVSLF---EGK 279 Query: 329 IELDPRGRIPVN-TRFQTKIPNIYAIGDVVAGPMLAHK-AEDEGIICV 374 ++ P G + T +P I+A GDV A G + Sbjct: 280 LKQKPNGYLWTAPDSTATDVPGIFAAGDVTDDIYRQAVTAAGMGCMAA 327 >3KLJ-A nrPDB Length = 385 Score = 85.0 bits (209), Expect = 8e-17, Method: Composition-based stats. Identities = 70/374 (18%), Positives = 127/374 (33%), Gaps = 75/374 (20%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHG 103 + ++G+GP G+ AA A G C ++ ++N+ Y Sbjct: 12 ILILGAGPAGFSAAKAAL----------------GKCDDI------TMINSEKY------ 43 Query: 104 KDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNG-YGKITGKNQV 162 + RLN + K+ ++ + +++N + + + N Sbjct: 44 -------LPYYRPRLN---EIIAKNKSIDDILIKKNDWYEKNNIKVITSEFATSIDPNNK 93 Query: 163 TATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSS-TGALSLK---KVPEKMVV 218 T G + I + ++IA+GS DE + S AL +K K K + Sbjct: 94 LVTLKSG--EKIKYEKLIIASGSIANKIKVPHADEIFSLYSYDDALKIKDECKNKGKAFI 151 Query: 219 IGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKV 278 IG G++G+EL G + L + +D + + L + G K N+ Sbjct: 152 IGGGILGIELAQAIIDSGTPASIGIILEYPLERQLDRDGGLFLKDKLDRLGIKIYTNSNF 211 Query: 279 TGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIP 338 ++I ++ +G +P + E+ + I Sbjct: 212 EEM-------------------GDLIRSSCVITAVGVKPNLDFIK----DTEIASKRGIL 248 Query: 339 VNTRFQTKIPNIYAIGDVVA----GPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIY 394 VN +T I +IYA GDV P L + A +G + G +PS I Sbjct: 249 VNDHMETSIKDIYACGDVAEFYGKNPGLINIANKQGEVAGLNACGEDASYS-EIIPSPIL 307 Query: 395 --THPEVAWVGKSE 406 + + G E Sbjct: 308 KVSGISIISCGDIE 321 >2WHD-A nrPDB Length = 351 Score = 83.4 bits (205), Expect = 2e-16, Method: Composition-based stats. Identities = 73/367 (19%), Positives = 127/367 (34%), Gaps = 61/367 (16%) Query: 19 RISHGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 R SH ++G +A PLRT V +IGSGP + AAI AA+ K V E Sbjct: 17 RGSH-MEGSAAAPLRTR--------VCIIGSGPAAHTAAIYAARAELKPVLFEGWMA--- 64 Query: 79 TCLNVGCIPSKALLNNSHYYHMAHGKDFASR-GIEMSEVRLNLDKMMEQKSTAVKALTGG 137 + + + D + G + ++L + +++ G Sbjct: 65 -------------NDIAAGGQLTTTTDVENFPGFPTGIMGIDL-----MDNCRAQSVRFG 106 Query: 138 IAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGS--EVTPFPGITI 195 L V V+ + +VT+ + + +++ATG+ F G Sbjct: 107 TNIL--SETVTEVDFSAR---PFRVTSD-----STTVLADTVVVATGAVARRLYFSGSDT 156 Query: 196 DEDTIVS----STGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGV 251 + +S GA + + + + VIG G +E G+ + G+ V + Sbjct: 157 YWNRGISACAVCDGAAPIFRN-KPIAVIGGGDSAMEEGNFLTKYGSQVYIIHRRNTFRAS 215 Query: 252 GIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAAS--GGKAEVITCDVL 309 I R L + +++V A + G ++ + G+ + L Sbjct: 216 KIMQ------ARALSNPKIQVVWDSEVVEAYGGAGGGPLAGVKVKNLVTGEVSDLQVSGL 269 Query: 310 LVCIGRRPFTKNLGLEELGIELDPRGRIPVN-TRFQTKIPNIYAIGDVVAGPML-AHKAE 367 IG P TK L +EL G + T + ++A GDV A A Sbjct: 270 FFAIGHEPATKFL---NGQLELHADGYVATKPGSTHTSVEGVFAAGDVQDKKYRQAITAA 326 Query: 368 DEGIICV 374 G + Sbjct: 327 GSGCMAA 333 >2VDC-G nrPDB Length = 456 Score = 76.9 bits (188), Expect = 2e-14, Method: Composition-based stats. Identities = 48/236 (20%), Positives = 88/236 (37%), Gaps = 40/236 (16%) Query: 179 ILIATG---SEVTPFPG-----ITIDEDTIVSST--------GAL---SLKKVPEKMVVI 219 +L+ATG + PG I D + +S A SL + +VV+ Sbjct: 211 VLVATGVYKARDIKAPGSGLGNIVAALDYLTTSNKVSLGDTVEAYENGSLNAAGKHVVVL 270 Query: 220 GAGVIGVELGSVWQRLGA-DVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKV 278 G G ++ R GA V + G E++ +++G +F Sbjct: 271 GGGDTAMDCVRTAIRQGATSVKCLYRRDRKNMPGSQREVA-----HAEEEGVEFIWQAAP 325 Query: 279 TGATKKS------DGKIDVSIEAASG--------GKAEVITCDVLLVCIGRRPFTKNLGL 324 G T + +I + + A+G G + D+++ +G P Sbjct: 326 EGFTGDTVVTGVRAVRIHLGVADATGRQTPQVIEGSEFTVQADLVIKALGFEPEDLPNAF 385 Query: 325 EELGIELDPRGRIPVNTRFQ-TKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAG 379 +E +++ G + V+ R + T + ++A GD+V G L A +G EG+ Sbjct: 386 DEPELKVTRWGTLLVDHRTKMTNMDGVFAAGDIVRGASLVVWAIRDGRDAAEGIHA 441 >6GAS-A nrPDB Length = 331 Score = 76.5 bits (187), Expect = 3e-14, Method: Composition-based stats. Identities = 59/321 (18%), Positives = 103/321 (32%), Gaps = 48/321 (14%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMA 101 D+T+IG GP G A IE LGG S Y Sbjct: 10 YDITIIGGGPTGLFTAFYGGMRQASVKIIESLPQLGG--------------QLSALYPEK 55 Query: 102 HGKDFASRG-IEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKN 160 + D A + E+ NL + M++ V L + L KQ + Sbjct: 56 YIYDVAGFPKVRAQELVDNLKEQMKKFDPTVC-LEEAVDTLEKQADGIF----------- 103 Query: 161 QVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSL-----KKVPEK 215 K Q +K+++I G+ + ++ K ++ Sbjct: 104 -----KLVTNKQTHYSKSVIITAGNGAFQPRRLELEGTAKYEKKNLHYFVDDMNKFAGKR 158 Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 +VV G G V+ + + + VT V ++ L + Sbjct: 159 VVVFGGGDSAVDWTMMLEPIAEKVTIVHRRDKFRAH-------EHSVENLMNSRAEVSTP 211 Query: 276 TKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRG 335 D V ++ + +I D ++V G + + G+++ + Sbjct: 212 YVPVELI-GDDKIEQVVLQHVKTEEKVIIDVDDVIVNYGFVSSLGPI--KNWGLDI-QKN 267 Query: 336 RIPVNTRFQTKIPNIYAIGDV 356 I VN++ +T IP IYA GD+ Sbjct: 268 SILVNSKMETNIPGIYAAGDI 288 >5TWC-A nrPDB Length = 344 Score = 74.2 bits (181), Expect = 1e-13, Method: Composition-based stats. Identities = 64/364 (17%), Positives = 108/364 (29%), Gaps = 43/364 (11%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 102 DVT+IG GP G A+ A I+ LGG + + P K + + Sbjct: 3 DVTIIGGGPSGLYASFYAGLRDMSVRLIDVQSELGGK-MRI--YPEKIIWDIGGIAPKPC 59 Query: 103 ---GKDFASRGIEM-SEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITG 158 KD +G+ EV LN + +K A +K V + I Sbjct: 60 HEILKDTIKQGLYFKPEVHLNERVVDIRKKAERHFEVETEAGEIYTSKAVIIAIGAGIIN 119 Query: 159 KNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVV 218 Q+ G + N+ +V S + +++ Sbjct: 120 PKQLDVK----GVERYQLTNL------------------HYVVQSYRRFK----DKDVLI 153 Query: 219 IGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKV 278 G G ++ ++ VT V V G + K T++ Sbjct: 154 SGGGNTALDWAHDIAKIAKSVTVVYRKEDVSGHEAMKTLV-------TDLNVKLCPKTRI 206 Query: 279 TGATKKSDGK--IDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGR 336 D +V +E G + D +++ G L +++ R Sbjct: 207 KYLVGNDDETHISEVVLEHVESGDRHTVKFDDVIISHGFDRCNTLLSETSSKLDMHDDCR 266 Query: 337 IPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYN-CVPSVIYT 395 + T IP IYA GD+V +H +I + + + Sbjct: 267 VKGFGNTTTSIPGIYACGDIVYHDAKSHLIASAFSDGANAANLAKTYIQPDANAEGYVSS 326 Query: 396 HPEV 399 H EV Sbjct: 327 HHEV 330 >4OVI-A nrPDB Length = 542 Score = 70.3 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 39/256 (15%), Positives = 84/256 (32%), Gaps = 22/256 (8%) Query: 32 LRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKAL 91 + + P + DV V+G+G G A + +LG IE +GG Sbjct: 7 VDSRRQPPEEVDVLVVGAGFSGLYALYRLRELGRSVHVIETAGDVGGV------------ 54 Query: 92 LNNSHYYHMAHGKDFASRGIEMSEVRL---NLDKMMEQKSTAVKALTGGIAHLFKQNKVV 148 + Y + SE L N + + ++ + ++ + Sbjct: 55 WYWNRYPGARCDIESIEYCYSFSEEVLQEWNWTERYASQPEILRYINFVADKFDLRSGIT 114 Query: 149 HVNG-YGKITGKNQVTATKADGGTQVIDTKNILIATGS-EVTPFPGITIDEDTIVSSTGA 206 + T T I + +++A+G V P +D + Sbjct: 115 FHTTVTAAAFDEATNTWTVDTNHGDRIRARYLIMASGQLSVPQLPNFPGLKDFAGNLYHT 174 Query: 207 LSLKKVP-----EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNF 261 + P +++ VIG G G+++ + A++ + H + + F Sbjct: 175 GNWPHEPVDFSGQRVGVIGTGSSGIQVSPQIAKQAAELFVFQRTPHFAVPARNAPLDPEF 234 Query: 262 QRILQKQGFKFKLNTK 277 L+K+ +F+ ++ Sbjct: 235 LADLKKRYAEFREESR 250 >4G74-A nrPDB Length = 502 Score = 68.0 bits (165), Expect = 1e-11, Method: Composition-based stats. Identities = 58/293 (19%), Positives = 91/293 (31%), Gaps = 63/293 (21%) Query: 143 KQNKVVHVNGYGKIT--GKNQVTATKADGGTQ----------------VIDTKNILIATG 184 K+ V + +N VT +Q I ++ A G Sbjct: 107 KKGNVTYYEAEATSINPDRNTVTIKSLSAVSQLYQPENHLGLHQAEPAEIKYDYLISAVG 166 Query: 185 SEVTP--FPGI--------TIDEDTIVSSTGALSLKK---VPE------KMVVI------ 219 +E PG+ I + T A +L+K +P+ +++ I Sbjct: 167 AEPNTFGIPGVTDYGHFLKEIPNSLEIRRTFAANLEKANLLPKGDPERRRLLSIVVVGGG 226 Query: 220 -----GAG----VIGVELGSVWQRLGADV--TAVEFLGHVGGVGIDMEISKNFQRILQKQ 268 AG + +L L +V VE L + + ++S Q L+ Sbjct: 227 PTGVEAAGELQDYVHQDLRKFLPALAEEVQIHLVEALP-IVLNMFEKKLSSYAQSHLENT 285 Query: 269 GFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGR--RPFTKNLGLEE 326 K L T V +K + + E I L+ G RP +L + Sbjct: 286 SIKVHLRTAVAKVEEKQ--LLAKTKHEDGKITEETIPYGTLIWATGNKARPVITDLFKKI 343 Query: 327 LGIELDPRGRIPVNTRFQTKIP-NIYAIGDV--VAGPMLAHKAEDEGIICVEG 376 RG + VN Q K NI+AIGD P A A E + Sbjct: 344 PEQNSSKRG-LAVNDFLQVKGSNNIFAIGDNAFAGLPPTAQVAHQEAEYLAKN 395 >5NA1-A nrPDB Length = 408 Score = 66.9 bits (162), Expect = 2e-11, Method: Composition-based stats. Identities = 54/282 (19%), Positives = 93/282 (32%), Gaps = 57/282 (20%) Query: 138 IAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATG--SEVTPFPGITI 195 + + K++KV V + A K + + D +++A G SE G+ Sbjct: 73 VESVLKKDKVNFVQAEVTKIDR---DAKKVETNQGIYDFDILVVALGFVSETFGIEGMKD 129 Query: 196 DEDTIVSSTGALSLKKVPE-----------------KMVVIGAGVIGVELGSVW------ 232 I + A L + E ++V GAG GVE Sbjct: 130 HAFQIENVITARELSRHIEDKFANYAASKEKDDNDLSILVGGAGFTGVEFLGELTDRIPE 189 Query: 233 --QRLGAD-----VTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKS 285 + G D +T VE + + E+ + L+ +G +FK+ T + +K Sbjct: 190 LCSKYGVDQNKVKITCVEAAPKMLPM-FSEELVNHAVSYLEDRGVEFKIATPIVACNEKG 248 Query: 286 DGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQT 345 G+ + + + G R +K + G++ RGRI Sbjct: 249 -------FVVEVDGEKQQLNAGTSVWAAGVRG-SKLMEESFEGVK---RGRIVTKQDLTI 297 Query: 346 K-IPNIYAIGDVVAG---------PMLAHKAEDEGIICVEGM 377 NI+ IGD A P A A +G + + Sbjct: 298 NGYDNIFVIGDCSAFIPAGEERPLPTTAQIAMQQGESVAKNI 339 Score = 28.7 bits (63), Expect = 6.3, Method: Composition-based stats. Identities = 23/123 (18%), Positives = 45/123 (36%), Gaps = 24/123 (19%) Query: 214 EKMVVIGAGVIGVE----LGSVWQRLGADVTAVEFLGHVGGVGIDMEISK---------- 259 +K++V+GAG G++ L A++T + + E S Sbjct: 12 KKVLVLGAGYAGLQTVTKLQKAISTEEAEITLINKNEYHYEATWLHEASAGTLNYEDVLY 71 Query: 260 NFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFT 319 + +L+K F +VT + + +E G + D+L+V +G T Sbjct: 72 PVESVLKKDKVNFV-QAEVTKIDRDAKK-----VETNQG----IYDFDILVVALGFVSET 121 Query: 320 KNL 322 + Sbjct: 122 FGI 124 >3UP5-A nrPDB Length = 545 Score = 65.7 bits (159), Expect = 4e-11, Method: Composition-based stats. Identities = 54/308 (17%), Positives = 101/308 (32%), Gaps = 47/308 (15%) Query: 32 LRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKAL 91 + A P D VIG+G G A Q G K + IE E +GGT Sbjct: 1 MSNRAKSP-ALDAVVIGAGVTGIYQAFLINQAGMKVLGIEAGEDVGGT------------ 47 Query: 92 LNNSHYYHMAHGKDFASRG----------IEMSEVRLNLDKMMEQKSTAVKALTGGIAHL 141 + Y + + G E SE + +M+ + A A+ + Sbjct: 48 WYWNRYPGCRLDTESYAYGYFALKGIIPEWEWSENFASQPEMLRYVNRAADAM--DVRKH 105 Query: 142 FKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATG----SEVTPFPGI-TID 196 ++ N V + +++ D +V+ + ++ ATG S + GI + Sbjct: 106 YRFN--TRVTA-ARYVENDRLWEVTLD-NEEVVTCRFLISATGPLSASRMPDIKGIDSFK 161 Query: 197 EDTIVSSTGALSLKKVP-------EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVG 249 ++ SS + P +++ VIG G GV++ + ++ + + Sbjct: 162 GESFHSSRWPTDAEGAPKGVDFTGKRVGVIGTGATGVQIIPIAAETAKELYVFQRTPNWC 221 Query: 250 GVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVL 309 + +SK L+ + K +D + G D Sbjct: 222 TPLGNSPMSKEKMDSLRNRYPTI------LEYVKSTDTAFPYHRDPRKGTDVSESERDAF 275 Query: 310 LVCIGRRP 317 + R+P Sbjct: 276 FEELYRQP 283 >4NTC-A nrPDB Length = 335 Score = 63.4 bits (153), Expect = 2e-10, Method: Composition-based stats. Identities = 57/357 (15%), Positives = 112/357 (31%), Gaps = 71/357 (19%) Query: 42 ADVTVIGSGPGGYVAAI-KAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHM 100 DV +IG+GP G A A QL V ++ Y + Sbjct: 15 VDVLIIGAGPAGLSTATGLARQLHTAVV-----------------------FDSGVYRNA 51 Query: 101 AHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAH-LFKQNKVVHVNGYGKITGK 159 G + E ++ LT + F+ + + + ++ Sbjct: 52 KTQHMHNVLGWDHRNPA-------ELRAAGRADLTTRYSTIQFQNSTIEAIR---QVETN 101 Query: 160 NQVTATKADGGTQVIDTKNILIATGSE--VTPFPGITI----DEDTIVSSTGALSLKKVP 213 A +G + + +++ATG G + + G ++ Sbjct: 102 QLFEARDNEGHSWY--GRKVVLATGVRDIPLDIEGYSECWANGIYHCLFCDGYE--ERGQ 157 Query: 214 EKMVVIGAGVIG-----VELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQ 268 E + V+ G I + L + RL VT + +++K Q+ ++ Sbjct: 158 ETVGVLALGPIANPARALHLARMALRLSESVTI--------YTNGNEQLAKEIQQAAEES 209 Query: 269 GFK---FKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTK--NLG 323 K + +K D V + G++E T L+ P T+ Sbjct: 210 PVGASGLKFEARPIRRFEKGDVAKTVIVHL---GESESKTEGFLVY----NPQTEVNGPF 262 Query: 324 LEELGIELDPRGRIPVNT-RFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAG 379 ++L + + G I ++T +P ++A+GD A G + G+ Sbjct: 263 AKQLALNMTEGGDILTTPPFYETSVPGVFAVGDCATPLKAVTPAVSMGSLAAGGLVA 319 >3K30-A nrPDB Length = 690 Score = 60.3 bits (145), Expect = 2e-09, Method: Composition-based stats. Identities = 64/365 (17%), Positives = 108/365 (29%), Gaps = 98/365 (26%) Query: 31 PLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKA 90 P R A + DA V V+G+GP G AA G+ V E LGG Sbjct: 382 PERIRAKES-DARVLVVGAGPSGLEAARALGVRGYDVVLAEAGRDLGG------------ 428 Query: 91 LLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHV 150 ++ A G+ ++ E + + L V Sbjct: 429 ----------RVTQESALPGLSA------WGRVKEYREAVLAEL----------PNVEIY 462 Query: 151 NGYGKITGKNQVTATKADGGTQVIDTKNILIATGS----------EVTPFPGITIDEDTI 200 +TG + V ++++ ATG+ T P + Sbjct: 463 R-ESPMTGDDIVE----------FGFEHVITATGATWRTDGVARFHTTALPIAEG--MQV 509 Query: 201 VSSTGALSLKKVPEKMVVIG-------AGVIGVELGSVWQRLGADVTAVEFLGHVGGVGI 253 + + + K VV+ GV+ + + G +V+ V V Sbjct: 510 LGPDDLFAGRLPDGKKVVVYDDDHYYLGGVV----AELLAQKGYEVSIVTPGAQVSSWTN 565 Query: 254 DMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCI 313 + QR L + G +VT + G V++ + CD +++ Sbjct: 566 NTFEVNRIQRRLIENGV-----ARVTDHAVVAVGAGGVTVRDTYASIERELECDAVVMVT 620 Query: 314 GRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNI---YAIGDVVAGPMLAHKAEDEG 370 R P + L L+ + G I + I +A G + A A G Sbjct: 621 ARLPR-EELYLDL--VARRDAGEIA-------SVRGIGDAWAPGTIAA-------AVWSG 663 Query: 371 IICVE 375 E Sbjct: 664 RRAAE 668 >4FK1-A nrPDB Length = 304 Score = 59.9 bits (144), Expect = 3e-09, Method: Composition-based stats. Identities = 56/339 (16%), Positives = 101/339 (29%), Gaps = 55/339 (16%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 102 D VIG+GP G A++ + + + N T N + H Sbjct: 8 DCAVIGAGPAGLNASLVLGRARKQIALFDNN-----TNRN----------RVTQNSHGFI 52 Query: 103 GKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQV 162 +D GI+ E + G+ + K V + + K Sbjct: 53 TRD----GIKPEEFK-----------------EIGLNEVMKYPSVHYYEKTVVMITKQST 91 Query: 163 TATKADGGTQV-IDTKNILIATG--SEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVI 219 + + +L+ATG E P + + S ++ ++ ++I Sbjct: 92 GLFEIVTKDHTKYLAERVLLATGMQEEFPSIPNVREYYGKSLFSCPYCDGWELKDQPLII 151 Query: 220 GAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVT 279 I + + E+S+ L + + Sbjct: 152 ----ISENEDHTLHMTKL---VYNWSTDLVIATNGNELSQTIMDELSNKNIPVITESI-- 202 Query: 280 GATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPV 339 T + +G +E SG + E +V RP +E+LG EL G + Sbjct: 203 -RTLQGEGGYLKKVEFHSGLRIE--RAGGFIVPTFFRPNQ---FIEQLGCELQSNGTFVI 256 Query: 340 NTRFQTKIPNIYAIGDVVA-GPMLAHKAEDEGIICVEGM 377 + +T NIY G+ GP A +G + Sbjct: 257 DDFGRTSEKNIYLAGETTTQGPSSLIIAASQGNKAAIAI 295 >1PS9-A nrPDB Length = 671 Score = 58.4 bits (140), Expect = 6e-09, Method: Composition-based stats. Identities = 52/314 (16%), Positives = 92/314 (29%), Gaps = 99/314 (31%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHG 103 + V+G+GP G AI AA G + + + +GG Sbjct: 376 LAVVGAGPAGLAFAINAAARGHQVTLFDAHSEIGG------------------------- 410 Query: 104 KDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVT 163 + N+ K + K + L + + V + + VT Sbjct: 411 -------------QFNIAKQIPGKEEFYETLRY-YRRMIEVTGVT-------LKLNHTVT 449 Query: 164 ATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVP--EKMVVIGA 221 A + + ++A+G P ID ++S L K P K+ +IG Sbjct: 450 ADQLQAFDET------ILASGIVPRTPPIDGIDHPKVLSYLDVLR-DKAPVGNKVAIIGC 502 Query: 222 GVIGVE---------------LGSVWQRLGAD----------------------VTAVEF 244 G IG + + G D + ++ Sbjct: 503 GGIGFDTAMYLSQPGESTSQNIAGFCNEWGIDSSLQQAGGLSPQGMQIPRSPRQIVMLQR 562 Query: 245 LGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVI 304 G G+ + L +G K K D + V I G+ +V+ Sbjct: 563 KASKPGQGLGKTTGWIHRTTLLSRGVKMIPG---VSYQKIDDDGLHVVI----NGETQVL 615 Query: 305 TCDVLLVCIGRRPF 318 D +++C G+ P Sbjct: 616 AVDNVVICAGQEPN 629 Score = 39.1 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 24/125 (19%), Positives = 41/125 (32%), Gaps = 31/125 (24%) Query: 209 LKKVPEK-MVVIGAGVIGVELGSVWQRLGADVTAVEF----------LGHVGGVGIDMEI 257 L V +K + V+GAG G+ G VT + + G E Sbjct: 368 LPAVQKKNLAVVGAGPAGLAFAINAAARGHQVTLFDAHSEIGGQFNIAKQIPGKEEFYET 427 Query: 258 SKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRP 317 + ++R+++ G KLN VT ++ D ++ G P Sbjct: 428 LRYYRRMIEVTGVTLKLNHTVTA--------------------DQLQAFDETILASGIVP 467 Query: 318 FTKNL 322 T + Sbjct: 468 RTPPI 472 Score = 31.8 bits (71), Expect = 0.73, Method: Composition-based stats. Identities = 35/212 (16%), Positives = 64/212 (30%), Gaps = 35/212 (16%) Query: 24 LQGLSAVPLRTYAD-----QPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 + G+ + +Y D P+ V +IG G G+ A+ +Q G T ++ + G Sbjct: 472 IDGIDHPKVLSYLDVLRDKAPVGNKVAIIGCGGIGFDTAMYLSQPGEST-----SQNIAG 526 Query: 79 TCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQK--STAVKALTG 136 C A G I S ++ + + K K Sbjct: 527 FC---------NEWGIDSSLQQAGGLSPQGMQIPRSPRQIVMLQRKASKPGQGLGKTTGW 577 Query: 137 GIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITID 196 V + G + +G TQV+ N++I G E + Sbjct: 578 IHRTTLLSRGVKMIPGVSYQKIDDDGLHVVINGETQVLAVDNVVICAGQEPNRALAQPLI 637 Query: 197 EDTIVSSTGALSLKKVPEKMVVIGAGVIGVEL 228 + + + +IG + +EL Sbjct: 638 DSG--------------KTVHLIGGCDVAMEL 655 >5JWC-A nrPDB Length = 521 Score = 58.4 bits (140), Expect = 7e-09, Method: Composition-based stats. Identities = 40/256 (15%), Positives = 73/256 (28%), Gaps = 45/256 (17%) Query: 150 VNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVT--PFPGITIDEDTIVSSTGAL 207 + + + + ++IA G++ G+ + AL Sbjct: 103 LECTDVFYEDKYINCIDIENNKVKLFYDYLIIAVGAKTNTFNINGVDKYAYFVKDIDDAL 162 Query: 208 SLKK----------VPE----------KMVVIGAGVIGVEL-GSVWQRLGADVTA----- 241 ++K +P + V+G G GVE+ + +V Sbjct: 163 KIRKKFLDILEKCTLPNISNEEKKKMLHVAVVGGGPTGVEVTAEFADFINKEVKINYKDI 222 Query: 242 -------VEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIE 294 + G+ IS + N V K + Sbjct: 223 FNFISISIIEGGNNLLPTFTQNISDFTKENFHNLNINVLTNYYVIDVDKH---SFHIQSS 279 Query: 295 AASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRI-PVNTRFQT-KIP--NI 350 K + ++ +L+ G T + I + I V+ + + IP NI Sbjct: 280 LNKNEKKK-LSYGLLIWASGL-AQTTLIQKFLKTIPVQANNAILKVDEKLRVIGIPSNNI 337 Query: 351 YAIGDVVA-GPMLAHK 365 YAIGD P L H+ Sbjct: 338 YAIGDCKKIQPKLLHE 353 >2CVJ-A nrPDB Length = 180 Score = 56.5 bits (135), Expect = 3e-08, Method: Composition-based stats. Identities = 32/166 (19%), Positives = 54/166 (32%), Gaps = 21/166 (12%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVG---------GVGIDMEISKNFQRIL 265 ++V+G G G+ R G V ++ +D + R L Sbjct: 3 DVIVVGGGPSGLSAALFLARAGLKVLVLDGGRSKVKGVSRVPNYPGLLDEPSGEELLRRL 62 Query: 266 QKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLE 325 + ++ + D +E G V + LL+C + P +L Sbjct: 63 EAHARRYGAEVRPGVVKGVRDMGGVFEVETEEG----VEKAERLLLCTHKDPTLPSL--- 115 Query: 326 ELGIELDPRG-RIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEG 370 + L RG I + +T P +YA G V G + H G Sbjct: 116 ---LGLTRRGAYIDTDEGGRTSYPRVYAAG-VARGKVPGHAIISAG 157 Score = 40.7 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 12/34 (35%), Positives = 19/34 (55%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET 75 DV V+G GP G AA+ A+ G K + ++ + Sbjct: 2 WDVIVVGGGPSGLSAALFLARAGLKVLVLDGGRS 35 >6A37-A nrPDB Length = 552 Score = 55.7 bits (133), Expect = 4e-08, Method: Composition-based stats. Identities = 35/229 (15%), Positives = 67/229 (29%), Gaps = 30/229 (13%) Query: 30 VPLRTYADQPIDADVTVIGSGPGGYVAAIKAA-QLGFKTVCIEKNETLGGTCLNVGCIPS 88 VP ++ Q +D D +IG+G GG + K K ++ +GGT Sbjct: 15 VPRGSHMTQKMDFDAIIIGAGFGGLYSLKKLRDDFNLKVRAFDRATEVGGT--------- 65 Query: 89 KALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKA------LTGGIAHLF 142 N + L + ME K + L Sbjct: 66 -WFWNQYPGALSDSETHLYCYSWDKE-----LLQEMEIKRKYISQPDVLAYLKRVADKHD 119 Query: 143 KQNKVVHVNG--YGKITGKNQVTATKADGGTQVIDTKNILIATG--SEV--TPFPGIT-I 195 + + G +N + + + ++ A G + GI Sbjct: 120 LRKDIQFETGIRSAYFDEENSFWNVTTE-NDEKFTARFLITALGLLAAPNLPKIKGIETF 178 Query: 196 DEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEF 244 + +S + +++ VIG G GV++ + +T + Sbjct: 179 KGELHHTSRWPKDVTFSGKRVGVIGTGSTGVQVITAIASQVKHLTVFQR 227 >2TMD-A nrPDB Length = 729 Score = 55.7 bits (133), Expect = 5e-08, Method: Composition-based stats. Identities = 60/377 (15%), Positives = 107/377 (28%), Gaps = 81/377 (21%) Query: 34 TYADQPIDAD-VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALL 92 Q + D V ++G+GP G AA + G+ + E +GG Sbjct: 381 EKFRQTKNKDSVLIVGAGPSGSEAARVLMESGYTVHLTDTAEKIGG-------------- 426 Query: 93 NNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNG 152 H+ G + + T + L K+NK + Sbjct: 427 ------HLNQVAALPGLG--------EWSYHRDYRETQITKL-------LKKNKESQLA- 464 Query: 153 YGKITGKNQVTATKADGGTQVIDTKNILIATGSE----------VTPFPGITIDEDTIVS 202 G+ +TA ++IATG+ P PG ++ Sbjct: 465 ----LGQKPMTADDVL----QYGADKVIIATGARWNTDGTNCLTHDPIPGADASLPDQLT 516 Query: 203 STGALS-LKKVPEKMVVIGAG--VIGVELGSVWQRLGADVTAVEFLGHVGGVGIDME--- 256 + KK+ +++V++ A + L G +VT V + + +E Sbjct: 517 PEQVMDGKKKIGKRVVILNADTYFMAPSLAEKLATAGHEVTIVSGVHLANYMHFTLEYPN 576 Query: 257 -ISKNFQRILQKQGFKFKLNTKVTGATKK---SDGKIDV-----SIEAASGGKAEVITCD 307 + + + +++ G F + DG + I D Sbjct: 577 MMRRLHELHVEELGDHFCSRIEPGRMEIYNIWGDGSKRTYRGPGVSPRDANTSHRWIEFD 636 Query: 308 VLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPMLAHKAE 367 L++ GR + + + I IY IGD P L A Sbjct: 637 SLVLVTGRHSECTLWNELKA----------RESEWAENDIKGIYLIGD-AEAPRLIADAT 685 Query: 368 DEGIICVEGMAGGAVHI 384 G + I Sbjct: 686 FTGHRVAREIEEANPQI 702 >4C5O-A nrPDB Length = 357 Score = 54.6 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 50/343 (14%), Positives = 102/343 (29%), Gaps = 55/343 (16%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMA 101 DV VIG G G A + G V ++ + GG H +H Sbjct: 4 VDVVVIGGGQSGLSAGYFLRRSGLSYVILDAEASPGGA------------WQ--HAWHSL 49 Query: 102 HGKDFASR----GIEMSEVRLNLDKMMEQKSTAVKALTGGIAH-LFKQNKVVHVNGYGKI 156 H A G M + + + A + + +V V+ +G+ Sbjct: 50 HLFSPAGWSSIPGWPMPASQGPYPA-RAEVLAYLAQYEQKYALPVLRPIRVQRVSHFGE- 107 Query: 157 TGKNQVTATKADGGTQVIDTKNILIATGSE----VTPFPGIT-IDEDTIVSSTGALSLKK 211 ++ DG + ++ ATG+ + G+ + S+ + Sbjct: 108 ----RLRVVARDGRQWLARA--VISATGTWGEAYTPEYQGLESFAGIQLHSAHYSTPAPF 161 Query: 212 VPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEIS-KNFQRILQKQG- 269 ++ +IG G G ++ + + +D + + + Q Sbjct: 162 AGMRVAIIGGGNSGAQILAEVSTVAETTWITRTEPAFLADDVDGRVLFERATERWKAQQE 221 Query: 270 ----------------FKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCI 313 L+ + G S D ++ C Sbjct: 222 GREPDLPPGGFGDIVMVPPVLDARARGVLAAVPPPARFSPTGMQWADGTERAFDAVIWCT 281 Query: 314 GRRPFTKNLGLEELGIELDPRGRIPVNTRF--QTKIPNIYAIG 354 G RP +L +L + P+G++ V+ +P+++ +G Sbjct: 282 GFRPALSHLKGLDL---VTPQGQVEVDGSGLRALAVPSVWLLG 321 >4USR-A nrPDB Length = 361 Score = 53.8 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 52/338 (15%), Positives = 111/338 (32%), Gaps = 49/338 (14%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAH 102 DV VIG G A + + +++ GG L+ ++ + A Sbjct: 9 DVIVIGGGQAALTTAYFLRRTSLSYLLLDEQPGPGGAWLHA--------WDSLRLFSPAA 60 Query: 103 GKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQV 162 A G M + ++ ++ V V+ ++ +V Sbjct: 61 WSSIA--GWPMPSPTEPGNPTRNDVIDYLRRYEDRYQFPIQRP--VRVDTVTRLDDLWRV 116 Query: 163 TATKADGGTQVIDTKNILIATGSE----VTPFPGITIDEDTIVSSTGALSL-KKVPEKMV 217 A G Q + ++ ATG+ + P+ G + + + S + ++++ Sbjct: 117 QA-----GDQQWLARAVISATGTWSKPFIPPYEGRELFQGAQIHSAHYRTPAPFAGKRVM 171 Query: 218 VIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEIS-KNFQRILQKQG------- 269 V+G G G ++ + + + + +D + + + Q Sbjct: 172 VVGGGNSGAQVLAELSSVSETLWITQEPPAFLPDEVDGRVLFERATARWKAQQEGRSIDE 231 Query: 270 -------------FKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRR 316 + V A + + +E A G + + D ++ C G R Sbjct: 232 PAGGFGDIVMVPPVREARERGVLVAERPFARFTETGVEWADGRRENL---DAVIWCSGFR 288 Query: 317 PFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIG 354 P L ELG+ ++ G++ V K PN++ +G Sbjct: 289 PALD--HLRELGV-VEADGKVQVEDTRVVKQPNLWLVG 323 >3H8L-A nrPDB Length = 409 Score = 53.8 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 52/309 (16%), Positives = 92/309 (29%), Gaps = 60/309 (19%) Query: 131 VKALTGGIAHLFKQNKVVHVNGYGKITGKNQ--VTATKADGGTQVIDTKNILIATGSEVT 188 V L ++ + + G + V TK DG + +++ G+ + Sbjct: 55 VDELKVDLSEALPEKGIQFQEGTVEKIDAKSSMVYYTKPDGSMAEEEYDYVIVGIGAHLA 114 Query: 189 PFPGITIDEDTIVSSTGALS------LKKVPEKMVVIGAG-------------------- 222 D+ + L+ + IG+G Sbjct: 115 TELVKGWDKYGYSVCEPEFATKLREKLESFQGGNIAIGSGPFYQGHNPKPKVPENFVPNA 174 Query: 223 VIGVE---------LGSVWQRLGA--DVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFK 271 E L +++ G V F + K I + G K Sbjct: 175 DSACEGPVFEMSLMLHGYFKKKGMLDKVHVTVFSPGEYLSDLSPNSRKAVASIYNQLGIK 234 Query: 272 FKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIEL 331 N K+ + K I D+ ++ P+T N L+ +L Sbjct: 235 LVHNFKIKEIREHE----------IVDEKGNTIPADITIL---LPPYTGNPALKNSTPDL 281 Query: 332 -DPRGRIPVNTRFQT-KIPNIYAIGDVV--AGPMLAHKAEDEGIICVEGMA---GGAVHI 384 D G IP + + K N+YA+GD P L + A G I + +A G + Sbjct: 282 VDDGGFIPTDLNMVSIKYDNVYAVGDANSMTVPKLGYLAVMTGRIAAQHLANRLGVPTKV 341 Query: 385 DYNCVPSVI 393 D P+++ Sbjct: 342 D-KYYPTIV 349 Score = 41.5 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 24/120 (20%), Positives = 43/120 (35%), Gaps = 20/120 (16%) Query: 215 KMVVIGAGVIGVELGSVWQRL---GADVTAVEFLG-----------HVGGVGIDMEISKN 260 K++V+G + +RL ADV + +G +D E+ + Sbjct: 3 KVLVLGGRFGALTAAYTLKRLVGSKADVKVINKSRFSYFRPALPHVAIGVRDVD-ELKVD 61 Query: 261 FQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTK 320 L ++G +F+ T +K D K + G D ++V IG T+ Sbjct: 62 LSEALPEKGIQFQEGT-----VEKIDAKSSMVYYTKPDGSMAEEEYDYVIVGIGAHLATE 116 >6JDK-A nrPDB Length = 544 Score = 52.2 bits (124), Expect = 5e-07, Method: Composition-based stats. Identities = 35/247 (14%), Positives = 77/247 (31%), Gaps = 35/247 (14%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG----TCLNVGCIPSKALLNNSHY 97 D ++G+G G + Q GFK E +GG C + S + Sbjct: 18 FDALIVGAGFNGIYQLHRLRQEGFKVRLFEAGADMGGIWYWNCYPGARVDSHIPIYEFSI 77 Query: 98 YHMAHGKDFASRGIEMSEVRLNLDKM------MEQKSTAVKALTGGIAHLFKQNKVVHVN 151 + R +E D++ +++K + + G+ Sbjct: 78 EEL-------WRDWNWTERFPAWDELRRYFHYVDKKLDLSRDIRFGMRVSA--------- 121 Query: 152 GYGKITGKNQVTATKADGGTQVIDTKNILIATG-SEVTPFPGITIDEDTIVSS-TGALSL 209 + + GT V+ + ++ TG + P E S L Sbjct: 122 --AEFDEARDQWVIRTTDGT-VVRARFFILCTGFASKPYIPNYKGLESFAGESFHTGLWP 178 Query: 210 KK----VPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRIL 265 ++ +++ V+G G GV++ + A +T + + ++ Q+ + Sbjct: 179 QEGASFTGKRVGVVGTGASGVQVVQEASKDAAHLTVFQRTPILALPMQQRKLDVETQQRM 238 Query: 266 QKQGFKF 272 + + Sbjct: 239 KADYPEI 245 >5NMX-A nrPDB Length = 425 Score = 50.7 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 35/210 (16%), Positives = 69/210 (32%), Gaps = 37/210 (17%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHG 103 V V+G+GP G AA Q GF+ + E+ +GGT N + M+ Sbjct: 4 VAVLGAGPSGLTAARYLKQAGFEVMVFERYHHVGGT------------WNYTDETWMSED 51 Query: 104 KDFASRGIEMSEVRLNLDK-MMEQKSTAVKALTGGI---AHLFK--QNKVVHVNGYGKIT 157 + +NL K +M + G + K N + I Sbjct: 52 GR-PVYSSMYQNLFVNLPKELMAFPDFPFHDIEGSYVPSKEVLKYFDNFTDAFDLRKLIK 110 Query: 158 GKNQVT-ATKADGG------------TQVIDTKNILIATG-SEVTPFPGITIDE---DTI 200 ++ V + G + +++ TG + +P + + Sbjct: 111 LQHHVENVRPCESGWLVTVTDLTTMVEHSFEFDAVVVCTGQTWCPLYPDVEGRSFFRGRL 170 Query: 201 VSSTGALSL-KKVPEKMVVIGAGVIGVELG 229 + S ++++++GAG G ++ Sbjct: 171 THAHEFRSPEPFRNKRVLIVGAGPSGHDMA 200 Score = 31.4 bits (70), Expect = 0.86, Method: Composition-based stats. Identities = 12/38 (31%), Positives = 19/38 (50%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGV 251 ++ V+GAG G+ ++ G +V E HVGG Sbjct: 2 RRVAVLGAGPSGLTAARYLKQAGFEVMVFERYHHVGGT 39 >1NAA-A nrPDB Length = 541 Score = 48.8 bits (115), Expect = 6e-06, Method: Composition-based stats. Identities = 14/45 (31%), Positives = 25/45 (55%), Gaps = 4/45 (8%) Query: 41 DADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET----LGGTCL 81 D ++G+GPGG +AA + ++ G K + +E+ GGT + Sbjct: 2 PYDYIIVGAGPGGIIAADRLSEAGKKVLLLERGGPSTKQTGGTYV 46 >5BR7-A nrPDB Length = 393 Score = 48.4 bits (114), Expect = 7e-06, Method: Composition-based stats. Identities = 19/39 (48%), Positives = 24/39 (61%), Gaps = 1/39 (2%) Query: 41 DADVTVIGSGPGGYVAAIKAA-QLGFKTVCIEKNETLGG 78 D D+ V+GSG G A +AA QLG K + +EK LGG Sbjct: 3 DFDLIVVGSGLFGLTVAERAASQLGKKVLIVEKRSHLGG 41 >3RHA-A nrPDB Length = 482 Score = 47.2 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 14/41 (34%), Positives = 23/41 (56%) Query: 38 QPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 Q +D DV ++G+GP G AA + + G +E + +GG Sbjct: 4 QNLDRDVVIVGAGPSGLTAARELKKAGLSVAVLEARDRVGG 44 Score = 39.1 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 13/56 (23%), Positives = 23/56 (41%) Query: 209 LKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRI 264 ++ + +V++GAG G+ ++ G V +E VGG I I Sbjct: 3 MQNLDRDVVIVGAGPSGLTAARELKKAGLSVAVLEARDRVGGRTWTDTIDGAMLEI 58 >3HYW-A nrPDB Length = 430 Score = 46.5 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 52/302 (17%), Positives = 94/302 (31%), Gaps = 53/302 (17%) Query: 100 MAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGK 159 + + + + + K + ++ +A L + + +N + Sbjct: 32 LISDRPYFGFTPAFPHLAMGWRKF--------EDISVPLAPLLPKFNIEFINEKAESIDP 83 Query: 160 NQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKM--- 216 + T T G I+ ++IATG G E+ S A + +K+ Sbjct: 84 DANTVTTQSGKK--IEYDYLVIATG--PKLVFGAEGQEENSTSICTAEHALETQKKLQEL 139 Query: 217 ------VVIGA--GVI----GVELGSVWQ--------RLGADVTAVE---FLGHVGGVGI 253 VVIGA GV E + R +T + +LGH G GI Sbjct: 140 YANPGPVVIGAIPGVSCFGPAYEFALMLHYELKKRGIRYKVPMTFITSEPYLGHFGVGGI 199 Query: 254 DMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCI 313 + + + ++ + N V V E +G EV + + Sbjct: 200 GAS-KRLVEDLFAERNIDWIANVAVKAIEPDK-----VIYEDLNGNTHEVPAKFTMFM-- 251 Query: 314 GRRPFTKN---LGLEELGIELDPRGRIPVNTRFQT-KIPNIYAIGDVVAGPMLAHKAEDE 369 P + + + + VN FQ NI+ +G V A P + Sbjct: 252 ---PSFQGPEVVASAGDKVANPANKMVIVNRCFQNPTYKNIFGVGVVTAIPPIEKTPIPT 308 Query: 370 GI 371 G+ Sbjct: 309 GV 310 >3NIX-A nrPDB Length = 421 Score = 46.5 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 38/175 (21%), Positives = 61/175 (34%), Gaps = 36/175 (20%) Query: 41 DADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET----LGGTCLNVGCIPS-------- 88 DV VIG+GP G VAA + GFK +EK + +G + L C+ Sbjct: 5 KVDVLVIGAGPAGTVAASLVNKSGFKVKIVEKQKFPRFVIGESLLPR-CMEHLDEAGFLD 63 Query: 89 --KA----------LLNNSHYYHMAHGKDFA-SRGIEMSEVRLNLDKMMEQKSTAVKALT 135 KA + F+ R N DK + +A Sbjct: 64 AVKAQGFQQKFGAKFVRGKEIADFNFSDQFSNGWNWTWQVPRGNFDKTLAD-----EAAR 118 Query: 136 GGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATG-SEVTP 189 G+ + + V + +G + T +G + I+ + I+ A+G V P Sbjct: 119 QGVDVEY-EVGVTDIKFFGT---DSVTTIEDINGNKREIEARFIIDASGYGRVIP 169 Score = 33.0 bits (74), Expect = 0.30, Method: Composition-based stats. Identities = 18/80 (22%), Positives = 30/80 (37%), Gaps = 8/80 (10%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFL--------GHVGGVGIDMEISKNFQRILQ 266 ++VIGAG G S+ + G V VE + ++ F ++ Sbjct: 7 DVLVIGAGPAGTVAASLVNKSGFKVKIVEKQKFPRFVIGESLLPRCMEHLDEAGFLDAVK 66 Query: 267 KQGFKFKLNTKVTGATKKSD 286 QGF+ K K + +D Sbjct: 67 AQGFQQKFGAKFVRGKEIAD 86 >6ER9-A nrPDB Length = 549 Score = 46.5 bits (109), Expect = 3e-05, Method: Composition-based stats. Identities = 45/218 (20%), Positives = 77/218 (35%), Gaps = 18/218 (8%) Query: 38 QPIDADVTVIGSGPGGYVAAIKA-AQLGFKTVCIEKNETLGGTCL-NVGCIPSKALLNNS 95 P D VIG+G GG A K + G V +K + GGT N P S Sbjct: 6 SPTVVDAVVIGAGFGGIYAVHKLHNEQGLTVVGFDKADGPGGTWYWNR--YPGALSDTES 63 Query: 96 HYYHMAHGKDFASRG-IEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYG 154 H Y + +D G + + + +++E + V F V Sbjct: 64 HLYRFSFDRDLLQDGTWKTTYITQ--PEILEYLESVVDRFDLRRHFRFG----TEVTSAI 117 Query: 155 KITGKNQVTATKADGGTQVIDTKNILIATG--SEV--TPFPGI-TIDEDTIVSSTGALSL 209 + +N + G +V K ++ A G S + PG+ T + +TI ++ Sbjct: 118 YLEDENLWEVSTDKG--EVYRAKYVVNAVGLLSAINFPDLPGLDTFEGETIHTAAWPEGK 175 Query: 210 KKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGH 247 +++ VIG G G ++ + +T Sbjct: 176 NLAGKRVGVIGTGSTGQQVITALAPEVEHLTVFVRTPQ 213 >5J7X-A nrPDB Length = 549 Score = 46.1 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 45/236 (19%), Positives = 79/236 (33%), Gaps = 33/236 (13%) Query: 43 DVTVIGSG-PGGYVAAIKAAQLGFKTVCIEKNETLGGTCLN-------VGC-IPSKALLN 93 D +IGSG G Y+ +L K E +GGT N V C +P A Sbjct: 14 DALIIGSGFSGIYLLHKLRDELKLKVKIFEAESDIGGTWNNNRYPGARVDCPVPFYA--- 70 Query: 94 NSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGY 153 + + +E+ N ++ V + ++V Sbjct: 71 --------YSLPEVWQSWNWTELYPNQKEIKSYFD-HVDRVLDVRKDCLFHSRVN----E 117 Query: 154 GKITGKNQVTATKADGGTQVIDTKNILIATG-SEVTPFP---GITIDEDTIVSST---GA 206 G + T +V K +L+A G + + P G+ + TI S A Sbjct: 118 GTF-DEATGRWTVWTTDGKVATAKYLLVAVGFASKSYLPDWKGLDSFKGTIYHSAHWPEA 176 Query: 207 LSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQ 262 + +K+ VIG G G+++ W R + + ++ E+ +Q Sbjct: 177 EEISVKGKKVAVIGTGSTGIQIFQEWAREAEEAFLFQRTPNLCLPMRQQELHAGYQ 232 Score = 29.5 bits (65), Expect = 3.1, Method: Composition-based stats. Identities = 16/64 (25%), Positives = 26/64 (40%), Gaps = 4/64 (6%) Query: 275 NTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKN---LGLEEL-GIE 330 + V KS + V+ +V D++ V G T LGL+++ G+ Sbjct: 350 KSNVHIVDTKSQPIVGVTPTGIVTADEKVHEVDIIAVATGFDAVTGGLLRLGLKDVNGVG 409 Query: 331 LDPR 334 LD R Sbjct: 410 LDER 413 >3KVE-A nrPDB Length = 486 Score = 44.5 bits (104), Expect = 9e-05, Method: Composition-based stats. Identities = 14/39 (35%), Positives = 20/39 (51%) Query: 213 PEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGV 251 P+ +VV+GAG+ G+ V G VT +E GG Sbjct: 33 PKHVVVVGAGMSGLSAAYVLAGAGHKVTVLEASERAGGR 71 Score = 37.6 bits (86), Expect = 0.012, Method: Composition-based stats. Identities = 49/281 (17%), Positives = 91/281 (32%), Gaps = 33/281 (11%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG---TCLNVGCIPSKALLNNSHYYHM 100 V V+G+G G AA A G K +E +E GG T N SK + Sbjct: 36 VVVVGAGMSGLSAAYVLAGAGHKVTVLEASERAGGRVRTHRN-----SKEGWYANLGPMR 90 Query: 101 AHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKN 160 K R + + LNL++ ++ A ++ G + Sbjct: 91 IPEKHRIVREY-IRKFGLNLNEFSQENDNA-----WYFIKNIRKRVGEVNKDPGLLKYPV 144 Query: 161 QVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIG 220 + + G ++ GS V I++ S K+ K + Sbjct: 145 KPSEEGKSAGQLYEES------LGSAVKDLKRTNC--SYILNKYDTYSTKEYLIKEGNLS 196 Query: 221 AGVIGVELGSVWQR-LGADVTAVEFLGHVGGVGIDMEISKNF-------QRILQKQGFKF 272 G + + +G + G V+ +E L H + + + + K Sbjct: 197 PGAVDM-IGDLLNEDSGYYVSFIESLKHDDIFAYEKRFDEIVGGMDQLPTSMYRAIEEKV 255 Query: 273 KLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCI 313 K N +V + ++ ++ V+ + T D ++VC Sbjct: 256 KFNARVIKIQQNAN-QVTVTYQ-TPEKDTSSNTADYVIVCT 294 >4RG3-A nrPDB Length = 548 Score = 44.5 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 48/220 (21%), Positives = 77/220 (35%), Gaps = 23/220 (10%) Query: 32 LRTYADQPIDADVTVIGSGPGGYVAAIKA-AQLGFKTVCIEKNETLGGTCL-NVGCIPSK 89 + A D VIG+G GG A K +LG TV +K + GGT N P Sbjct: 7 MHMTAQTTHTVDAVVIGAGFGGIYAVHKLHHELGLTTVGFDKADGPGGTWYWNR--YPGA 64 Query: 90 ALLNNSHYYHMAHGKD-FASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFK-QNKV 147 SH Y + +D + + + +++E V + FK +V Sbjct: 65 LSDTESHLYRFSFDRDLLQESTWKTTYITQ--PEILEYLEDVVDR--FDLRRHFKFGTEV 120 Query: 148 VHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATG--SEV--TPFPGI-TIDEDTIVS 202 + D +V K ++ A G S + PG+ T + +TI + Sbjct: 121 TS----ALYLDDENLWEVTTD-HGEVYRAKYVVNAVGLLSAINFPNLPGLDTFEGETIHT 175 Query: 203 STGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAV 242 + ++ VIG G G V L +V + Sbjct: 176 AAWPEGKSLAGRRVGVIGTGSTG---QQVITSLAPEVEHL 212 >5EQD-A nrPDB Length = 400 Score = 44.5 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 16/39 (41%), Positives = 24/39 (61%), Gaps = 1/39 (2%) Query: 41 DADVTVIGSGPGGYVAAIKAA-QLGFKTVCIEKNETLGG 78 + D+ V+GSG G A +AA QLG + + IE+ +GG Sbjct: 4 NFDLFVVGSGFFGLTIAERAATQLGKRVLVIERRPHIGG 42 Score = 32.6 bits (73), Expect = 0.41, Method: Composition-based stats. Identities = 16/66 (24%), Positives = 25/66 (37%), Gaps = 11/66 (16%) Query: 203 STGALSLKKVPEKMVVIGAGVIGVELGS-VWQRLGADVTAVEFLGHVGGVGI---DMEIS 258 STG L V+G+G G+ + +LG V +E H+GG + E Sbjct: 1 STGNFDL-------FVVGSGFFGLTIAERAATQLGKRVLVIERRPHIGGNAYSEPEPETG 53 Query: 259 KNFQRI 264 + Sbjct: 54 IEVHKY 59 >2BXR-A nrPDB Length = 527 Score = 44.5 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 13/37 (35%), Positives = 18/37 (48%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 DV VIG G G AA + G + +E + +GG Sbjct: 14 FDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGG 50 Score = 39.1 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 12/39 (30%), Positives = 17/39 (43%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGI 253 +VVIG G+ G+ + G V +E VGG Sbjct: 15 DVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTY 53 >3T14-A nrPDB Length = 437 Score = 44.5 bits (104), Expect = 1e-04, Method: Composition-based stats. Identities = 68/336 (20%), Positives = 121/336 (36%), Gaps = 82/336 (24%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLG-GTCLNVGCIPSKALLNNSHYYHMAH 102 V ++G+G GG AA E E LG G + L++ + Y+ Sbjct: 7 VVILGAGTGGMPAAY------------EMKEALGSGHEV--------TLISANDYFQFVP 46 Query: 103 GKDFASRGI-EMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQ 161 + G E ++ + +E+K + + + Sbjct: 47 SNPWVGVGWKERDDIAFPIRHYVERK------------------GIHFIAQSAEQIDAEA 88 Query: 162 VTATKADGGTQVIDTKNILIATGSEVT--PFPGITIDEDTIVS------STGAL----SL 209 T ADG T + ++IATG ++ PG E + S + A +L Sbjct: 89 QNITLADGNT--VHYDYLMIATGPKLAFENVPGSDPHEGPVQSIATVDHAERAFAEYQAL 146 Query: 210 KKVPEKMVV---IGAGVIG------VELGSVWQRLGAD--------VTAVEFLGHVGGVG 252 + P +V+ GA G + + S ++ G +T+ ++GH+G G Sbjct: 147 LREPGPIVIGAMAGASCFGPAYEYAMIVASDLKKRGMRDKIPSFTFITSEPYIGHLGIQG 206 Query: 253 IDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVC 312 + + + L+++G + N KVT D K+ V+ K E I VL V Sbjct: 207 V-GDSKGILTKGLKEEGIEAYTNCKVTKVE---DNKMYVT---QVDEKGETIKEMVLPVK 259 Query: 313 IGRR-PFTKNLGLEELGIE--LDPRGRIPVNTRFQT 345 G P K + G+E +P G + V+ ++ Sbjct: 260 FGMMIPAFKGVPA-VAGVEGLCNPGGFVLVDEHQRS 294 >6CR0-A nrPDB Length = 440 Score = 44.2 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 29/165 (17%), Positives = 49/165 (29%), Gaps = 28/165 (16%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMA 101 D V+G+G G VAA + + G + IE LGG Sbjct: 9 YDAIVVGAGFSGLVAARELSAQGRSVLIIEARHRLGG---------------------RT 47 Query: 102 HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKV-VHVNGYGKITGKN 160 H +F R +E+ ++ V A FK+ + Y Sbjct: 48 HVVNFLGRPVEIGGAGVHWC------QPHVFAEMQRYGFGFKEAPLADLDKAYMVFADGQ 101 Query: 161 QVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTG 205 ++ A + + E+ P P +D + + G Sbjct: 102 KIDVPPATFDEEYTTAFEKFCSRSRELFPRPYSPLDNHEVSNLDG 146 Score = 31.4 bits (70), Expect = 0.83, Method: Composition-based stats. Identities = 10/37 (27%), Positives = 15/37 (40%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGV 251 +V+GAG G+ G V +E +GG Sbjct: 10 DAIVVGAGFSGLVAARELSAQGRSVLIIEARHRLGGR 46 >1REO-A nrPDB Length = 486 Score = 44.2 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 14/39 (35%), Positives = 20/39 (51%) Query: 213 PEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGV 251 P+ +VV+GAG+ G+ V G VT +E GG Sbjct: 33 PKHVVVVGAGMSGLSAAYVLSGAGHQVTVLEASERAGGR 71 Score = 33.8 bits (76), Expect = 0.19, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 18/35 (51%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 V V+G+G G AA + G + +E +E GG Sbjct: 36 VVVVGAGMSGLSAAYVLSGAGHQVTVLEASERAGG 70 >4TLZ-A nrPDB Length = 443 Score = 44.2 bits (103), Expect = 1e-04, Method: Composition-based stats. Identities = 45/256 (17%), Positives = 81/256 (31%), Gaps = 58/256 (22%) Query: 144 QNKVVHVN-GYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVS 202 ++V + G G+ V + + T+ ++ +NI+I+TG G+ DE + Sbjct: 144 DSEVTAIRPGPGRPVDSVLVDVSTPEA-TRTVEARNIVISTGLVPRMPAGVQSDE-FVWH 201 Query: 203 STGALS--LKKVP---EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDME- 256 S+ L + P ++ V G G E+ D + G V D Sbjct: 202 SSRFLDHFRDRDPRSLRRVAVAGGGQSAAEIVRFLHDNRPDTVVHAIMPSYGYVVADNTP 261 Query: 257 ------------------------------------ISKNFQRILQKQG----------F 270 + R L ++G Sbjct: 262 FANQIFDPAAVDDYFDGSKQAKDAFWRYHRNTNYSVVDDEVIRDLYRRGYDDEVAGAPRL 321 Query: 271 KFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIE 330 F V GA + +D V++ + + ++ + DVL+ G P L EL Sbjct: 322 NFVNLAHVVGAKRIAD-DTRVTVYSMAREESYDLDVDVLVCATGYDPMDPGDLLGELAEH 380 Query: 331 L--DPRGRIPVNTRFQ 344 D GR V+ ++ Sbjct: 381 CVQDAEGRWQVDRDYR 396 >4Y4N-A nrPDB Length = 286 Score = 44.2 bits (103), Expect = 2e-04, Method: Composition-based stats. Identities = 15/39 (38%), Positives = 22/39 (56%) Query: 38 QPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETL 76 ID DV ++G GP G AA A+ G+K V +E++ Sbjct: 49 DIIDVDVAIVGGGPSGLTAARYIAKEGYKVVVLERHLAF 87 Score = 28.4 bits (62), Expect = 8.3, Method: Composition-based stats. Identities = 9/45 (20%), Positives = 18/45 (40%) Query: 200 IVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEF 244 I+ S + L + + ++G G G+ + G V +E Sbjct: 39 ILKSAFDMWLDIIDVDVAIVGGGPSGLTAARYIAKEGYKVVVLER 83 >1Y56-A nrPDB Length = 493 Score = 43.8 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 43/296 (14%), Positives = 80/296 (27%), Gaps = 76/296 (25%) Query: 62 QLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLD 121 Q IE+ LGG D +GI+ + Sbjct: 128 QQYLTVALIEERGWLGG--------------------------DMWLKGIKQEGFNKDSR 161 Query: 122 KMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILI 181 K++E V L + + + + V + D +++ K +++ Sbjct: 162 KVVE---ELVGKLNENTKIYLETSALGVFDKGEYFL----VPVVRGDKLIEIL-AKRVVL 213 Query: 182 ATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQ-RLGADVT 240 ATG+ + ST +P + +E+ +VW+ G V Sbjct: 214 ATGA---------------IDSTMLFENNDMPG----VFRRDFALEVMNVWEVAPGRKVA 254 Query: 241 AVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGK 300 + + L++ G + V +E Sbjct: 255 VTGSK------------ADEVIQELERWGIDYVHIPNVKRVEGNE------KVERVIDMN 296 Query: 301 AEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRI--PVNTRFQTKIPNIYAIG 354 D L+ GRRP + + RG ++ + K IY G Sbjct: 297 NHEYKVDALIFADGRRPDINPITQAGGKLRF-RRGYYSPVLDEYHRIKD-GIYVAG 350 >1O5W-A nrPDB Length = 534 Score = 43.8 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 12/37 (32%), Positives = 18/37 (48%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 DV VIG G G AA ++ + +E + +GG Sbjct: 22 FDVVVIGGGISGLAAAKLLSEYKINVLVLEARDRVGG 58 Score = 36.4 bits (83), Expect = 0.030, Method: Composition-based stats. Identities = 11/39 (28%), Positives = 17/39 (43%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGI 253 +VVIG G+ G+ + +V +E VGG Sbjct: 23 DVVVIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTY 61 >4Y4M-A nrPDB Length = 290 Score = 43.8 bits (102), Expect = 2e-04, Method: Composition-based stats. Identities = 14/39 (35%), Positives = 23/39 (58%) Query: 38 QPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETL 76 ++ADV ++G+GP G A A+ GFK V +E++ Sbjct: 56 DIVEADVVIVGAGPSGLTCARYLAKEGFKVVVLERHLAF 94 Score = 31.8 bits (71), Expect = 0.65, Method: Composition-based stats. Identities = 31/171 (18%), Positives = 50/171 (29%), Gaps = 43/171 (25%) Query: 208 SLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEF----------------------- 244 L V +V++GAG G+ + G V +E Sbjct: 54 WLDIVEADVVIVGAGPSGLTCARYLAKEGFKVVVLERHLAFGGGTWGGGMGFPYIVVEEP 113 Query: 245 ----LGHVGGVGIDMEISKNFQRILQ----------KQGFKFKLNTKVTGATKKSDGKID 290 L VG IDM ++ G K V + DG Sbjct: 114 ADELLREVGIKLIDMGDGYYVADSVEVPAKLAVAAMDAGAKILTGIVVEDLILREDGVAG 173 Query: 291 VSIEAASGGKAE------VITCDVLLVCIGRRPFTKNLGLEELGIELDPRG 335 V I + + +A I V++ G N+ +++ +E D G Sbjct: 174 VVINSYAIERAGLHIDPLTIRSKVVVDATGHEASIVNILVKKNKLEADVPG 224 >4C3X-A nrPDB Length = 530 Score = 43.4 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 18/42 (42%), Positives = 22/42 (52%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVG 84 DV V+GSG G A AA G T+ +EK + GGT G Sbjct: 29 DVLVVGSGGGALTGAYTAAAQGLTTIVLEKTDRFGGTSAYSG 70 >4AP1-A nrPDB Length = 549 Score = 43.4 bits (101), Expect = 2e-04, Method: Composition-based stats. Identities = 30/215 (13%), Positives = 60/215 (27%), Gaps = 22/215 (10%) Query: 22 HGLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCL 81 +G S V DV V+G+G G A + G E +GG Sbjct: 2 NGQHPRSVVTAPDATTGTTSYDVVVVGAGIAGLYAIHRFRSQGLTVRAFEAASGVGGV-- 59 Query: 82 NVGCIPSKALLNNSHYYHMAHGKDFASRGIEMS---EVRLNLDKMMEQKSTAVKALTGGI 138 + Y + S E N + + + L Sbjct: 60 ----------WYWNRYPGARCDVESIDYSYSFSPELEQEWNWSEKYATQPEILAYLEHVA 109 Query: 139 AHLFKQNKVVHV-NGYGKITGKNQVTATKADGGTQVIDTKNILIATG----SEVTPFPGI 193 + + + + + T + + +++A G + F G+ Sbjct: 110 DRFDLRRDIRFDTRVTSAVLDEEGLRWTVRTDRGDEVSARFLVVAAGPLSNANTPAFDGL 169 Query: 194 T-IDEDTIVSSTGALS-LKKVPEKMVVIGAGVIGV 226 D + ++ + +++ VIG G G+ Sbjct: 170 DRFTGDIVHTARWPHDGVDFTGKRVGVIGTGSSGI 204 >2GAG-A nrPDB Length = 965 Score = 42.6 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 56/299 (18%), Positives = 99/299 (33%), Gaps = 53/299 (17%) Query: 35 YADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNN 94 Y + DV V+G+GP G AA +A++ G + + +++ GGT LL+ Sbjct: 122 YDHVHVHTDVLVVGAGPAGLAAAREASRSGARVMLLDERAEAGGT-----------LLDT 170 Query: 95 SHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLF---KQNKVVHVN 151 + G D ++ + +V L + E + G + Q + VH++ Sbjct: 171 A--GEQIDGMDSSAW---IEQVTSELAEAEETTHLQRTTVFGSYDANYLIAAQRRTVHLD 225 Query: 152 G-YGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPF-------PGITIDEDTIVSS 203 G G + ++ I K +++ATG+ P PGI + V S Sbjct: 226 GPSGPGVSRERIW---------HIRAKQVVLATGAHERPIVFENNDRPGIMLAGA--VRS 274 Query: 204 TGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQR 263 + ++ V EL G V ++ Sbjct: 275 YLNRYGVRAGARIAVATTNDSAYELVRELAATGGVVAVIDARSS----------ISAAAA 324 Query: 264 ILQKQGFKFKLNTKVTGATKKSDGKIDVSI-----EAASGGKAEVITCDVLLVCIGRRP 317 G + + V +G++ + EA G + DVL V G P Sbjct: 325 QAVADGVQVISGSVVVDTEADENGELSAIVVAELDEARELGGTQRFEADVLAVAGGFNP 383 >2VVL-G nrPDB Length = 495 Score = 42.6 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 1/54 (1%) Query: 26 GLSAVPLR-TYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 G+ + P D+ DV VIG G G A GFKT+ +E + +GG Sbjct: 23 GVISPPTNIEDTDKDGPWDVIVIGGGYCGLTATRDLTVAGFKTLLLEARDRIGG 76 Score = 36.1 bits (82), Expect = 0.039, Method: Composition-based stats. Identities = 11/48 (22%), Positives = 16/48 (33%) Query: 213 PEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKN 260 P ++VIG G G+ G +E +GG I Sbjct: 39 PWDVIVIGGGYCGLTATRDLTVAGFKTLLLEARDRIGGRSWSSNIDGY 86 >4TXK-A nrPDB Length = 615 Score = 42.6 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 15/50 (30%), Positives = 25/50 (50%) Query: 24 LQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKN 73 L ++ P+ + V+G+GP G AA++ A LG + V +EK Sbjct: 67 LDKRASQPVYQQGQACTNTKCLVVGAGPCGLRAAVELALLGARVVLVEKR 116 Score = 30.7 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 12/31 (38%), Positives = 15/31 (48%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFL 245 K +V+GAG G+ LGA V VE Sbjct: 86 KCLVVGAGPCGLRAAVELALLGARVVLVEKR 116 >2BRY-A nrPDB Length = 497 Score = 42.6 bits (99), Expect = 4e-04, Method: Composition-based stats. Identities = 15/50 (30%), Positives = 25/50 (50%) Query: 24 LQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKN 73 L ++ P+ + V+G+GP G AA++ A LG + V +EK Sbjct: 75 LDKRASQPVYQQGQACTNTKCLVVGAGPCGLRAAVELALLGARVVLVEKR 124 Score = 30.7 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 12/31 (38%), Positives = 15/31 (48%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFL 245 K +V+GAG G+ LGA V VE Sbjct: 94 KCLVVGAGPCGLRAAVELALLGARVVLVEKR 124 >3NK2-X nrPDB Length = 431 Score = 42.2 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 14/37 (37%), Positives = 17/37 (45%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 D V+G G G AA G K + +E E LGG Sbjct: 2 YDAIVVGGGFSGLKAARDLTNAGKKVLLLEGGERLGG 38 Score = 35.7 bits (81), Expect = 0.047, Method: Composition-based stats. Identities = 11/64 (17%), Positives = 19/64 (29%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL 274 +V+G G G++ G V +E +GG E ++ G Sbjct: 3 DAIVVGGGFSGLKAARDLTNAGKKVLLLEGGERLGGRAYSRESRNVPGLRVEIGGAYLHR 62 Query: 275 NTKV 278 Sbjct: 63 KHHP 66 >1F8S-A nrPDB Length = 498 Score = 42.2 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 13/39 (33%), Positives = 20/39 (51%) Query: 213 PEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGV 251 P+ +V++GAG+ G+ V G VT +E GG Sbjct: 33 PKHVVIVGAGMAGLSAAYVLAGAGHQVTVLEASERPGGR 71 Score = 37.2 bits (85), Expect = 0.016, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 18/35 (51%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 V ++G+G G AA A G + +E +E GG Sbjct: 36 VVIVGAGMAGLSAAYVLAGAGHQVTVLEASERPGG 70 Score = 29.9 bits (66), Expect = 3.0, Method: Composition-based stats. Identities = 17/85 (20%), Positives = 30/85 (35%), Gaps = 9/85 (10%) Query: 236 GADVTAVEFLGHVGGVGIDMEISKNF-------QRILQKQGFKFKLNTKVTGATKKSDGK 288 G V+ +E L H + + + + K N +V + D K Sbjct: 212 GYYVSFIESLKHDDIFAYEKRFDEIVDGMDKLPTAMYRDIQDKVHFNAQVIKIQQN-DQK 270 Query: 289 IDVSIEAASGGKAEVITCDVLLVCI 313 + V E S + +T D ++VC Sbjct: 271 VTVVYETLS-KETPSVTADYVIVCT 294 >3MJ4-A nrPDB Length = 397 Score = 42.2 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 10/37 (27%), Positives = 20/37 (54%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 D ++G+G G V A + A G + + +++ +GG Sbjct: 30 FDYLIVGAGFAGSVLAERLASSGQRVLIVDRRPHIGG 66 Score = 33.8 bits (76), Expect = 0.19, Method: Composition-based stats. Identities = 12/38 (31%), Positives = 17/38 (44%) Query: 217 VVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGID 254 +++GAG G L G V V+ H+GG D Sbjct: 33 LIVGAGFAGSVLAERLASSGQRVLIVDRRPHIGGNAYD 70 >5GSN-A nrPDB Length = 453 Score = 42.2 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 50/228 (21%), Positives = 75/228 (32%), Gaps = 43/228 (18%) Query: 44 VTVIGSGPGGYV---AAIKAAQLGF---KTVCIEKNETLGG-------TCL-----NVGC 85 V VIG+GP G A AA G + VC EK GG T L V C Sbjct: 5 VAVIGAGPSGLAQLRAFQSAADQGAEIPEIVCFEKQANWGGLWNYTWRTGLDENGEPVHC 64 Query: 86 I---------PSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTG 136 P + L + + GK AS V + + K+ K + Sbjct: 65 SMYRYLWSNGPKEGLEFADYSFEEHFGKQIASYPPRA--VLFDYIEGRVHKADVRKWIRF 122 Query: 137 GIAHLFKQNKVVHVNGYGKITGKNQVTATKAD-GGTQVIDTKNILIATGS-EVTPFP--- 191 + V + K VTA + T +++ A+G P Sbjct: 123 NSPVRW----VSYDAETAKF----TVTAHNHETDSTYSAAFDHVICASGHFSTPNVPFYE 174 Query: 192 GITIDEDTIVSSTGALSLKKVPEK-MVVIGAGVIGVELGSVWQRLGAD 238 G IV + ++ K ++V+GA ++GS + GA Sbjct: 175 GFDTFNGRIVHAHDFRDAREFEGKDVLVMGASSSAEDIGSQCWKYGAK 222 >1I8T-A nrPDB Length = 367 Score = 42.2 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 17/58 (29%), Positives = 26/58 (44%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYH 99 D ++GSG G V A + +L K + IEK +GG C + +H +H Sbjct: 2 YDYIIVGSGLFGAVCANELKKLNKKVLVIEKRNHIGGNAYTEDCEGIQIHKYGAHIFH 59 Score = 32.6 bits (73), Expect = 0.46, Method: Composition-based stats. Identities = 12/61 (19%), Positives = 23/61 (37%), Gaps = 2/61 (3%) Query: 217 VVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNT 276 +++G+G+ G + ++L V +E H+GG + F N Sbjct: 5 IIVGSGLFGAVCANELKKLNKKVLVIEKRNHIGGNAYTEDCEGIQIHKYGAH--IFHTND 62 Query: 277 K 277 K Sbjct: 63 K 63 >3BHF-A nrPDB Length = 390 Score = 41.8 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 44/275 (16%), Positives = 80/275 (29%), Gaps = 78/275 (28%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMA 101 DV V+G+G G A + A+ G KT+ ++ + P N SH+ Sbjct: 5 FDVIVVGAGSMGMAAGYQLAKQGVKTLLVDAFDP-----------PHT---NGSHHGDTK 50 Query: 102 HGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHV--NGYGKITGK 159 + G E + L ++ + +F + V+ G + Sbjct: 51 IIRHAYGEGREYVPLALRSQELWYELEKETH------HKIFTKTGVLVFGPKGESAFVAE 104 Query: 160 NQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVI 219 A + +++ I +PGIT+ E+ Sbjct: 105 TMEAAKEHSLTVDLLEGDEI-------NKRWPGITVPENY----NAIFEPN--------- 144 Query: 220 GAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVT 279 V + ++ + + +G K +T+V Sbjct: 145 ---------SGVL--------------------FSENCIRAYRELAEARGAKVLTHTRVE 175 Query: 280 GATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIG 314 D V IE A+G T D L+V +G Sbjct: 176 DFDISPD---SVKIETANGS----YTADKLIVSMG 203 >2JB2-A nrPDB Length = 489 Score = 41.5 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 18/35 (51%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 V V+G GP G +A + + G+K +E GG Sbjct: 14 VVVLGGGPAGLCSAFELQKAGYKVTVLEARTRPGG 48 Score = 31.4 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 12/41 (29%), Positives = 17/41 (41%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDM 255 +VV+G G G+ Q+ G VT +E GG Sbjct: 13 SVVVLGGGPAGLCSAFELQKAGYKVTVLEARTRPGGRVWTA 53 >3ABT-A nrPDB Length = 662 Score = 41.5 bits (96), Expect = 0.001, Method: Composition-based stats. Identities = 15/38 (39%), Positives = 21/38 (55%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGV 251 K+++IG+GV G+ Q G DVT +E VGG Sbjct: 108 GKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGR 145 Score = 38.4 bits (88), Expect = 0.008, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 17/35 (48%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 V +IGSG G AA + G +E + +GG Sbjct: 110 VIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGG 144 >5L3D-A nrPDB Length = 852 Score = 41.1 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 15/38 (39%), Positives = 21/38 (55%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGV 251 K+++IG+GV G+ Q G DVT +E VGG Sbjct: 279 GKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGR 316 Score = 38.0 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 17/35 (48%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 V +IGSG G AA + G +E + +GG Sbjct: 281 VIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGG 315 >2GMH-A nrPDB Length = 584 Score = 41.1 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 18/52 (34%), Positives = 26/52 (50%), Gaps = 11/52 (21%) Query: 41 DADVTVIGSGPGGYVAAIK----AAQL--GFKTVCIEKNETLG-----GTCL 81 +ADV ++G+GP G AA + AAQ + +EK +G G CL Sbjct: 35 EADVVIVGAGPAGLSAATRLKQLAAQHEKDLRVCLVEKAAHIGAHTLSGACL 86 >1ZOV-A nrPDB Length = 386 Score = 41.1 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 11/30 (36%), Positives = 17/30 (56%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIE 71 DV V+G+G G A A+ G KT+ ++ Sbjct: 4 FDVIVVGAGSMGMAAGYYLAKQGVKTLLVD 33 >5CQF-A nrPDB Length = 443 Score = 40.7 bits (94), Expect = 0.002, Method: Composition-based stats. Identities = 57/390 (14%), Positives = 109/390 (27%), Gaps = 99/390 (25%) Query: 38 QPIDADVTVIGSGPGG------YVAAIKAAQ-LG-FKTVCIEKNET--------LGGTCL 81 + +D IG GP G + A +A+Q LG +E L GT + Sbjct: 10 HSLHSDAICIGFGPAGIALACAFEDAREASQPLGDLSIGYLEAAPDTQWHRELLLAGTDI 69 Query: 82 N----VGCI----PSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKA 133 N + P + DF G S R + S V Sbjct: 70 NHHVFRDLVTPRNPRSRFSFAMYLKDQGRMFDFGLLGRPAS--RHEWSDYLGWVSRQVDG 127 Query: 134 LTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGI 193 + V NG +V G T+N+++++GS P Sbjct: 128 -HTRFDTPVTEIDPVIRNGR-----LQEVRVRTPQGS---FATRNLVLSSGSAP-RIPQA 177 Query: 194 TID--------EDTIVSSTGALSLKKVPEKMVVIGAGVIGVE------------------ 227 ++ A K++P++ +V+G+G E Sbjct: 178 FEALLGPTLFHTSRFLTRLQAFG-KQLPKRWLVLGSGQSASESVLELVSRDPAIEVHSVH 236 Query: 228 -LGSV-WQRLG------ADVTAVEFLGHVGGV---------------GIDMEISKNFQRI 264 +LG V++ + GID + + + Sbjct: 237 RCAGFKLTQLGQFPNRVFAPDHVDYFHSLNPAARQRFLDWSRSTNYAGIDPDERQKLFSL 296 Query: 265 LQKQGF----KFKLNT-KVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRR--- 316 + + + V A + + V + + V+ D +++ G + Sbjct: 297 IYEDSIAGRTRLHTYAYSVISAIEHTADGYRVELTDTFSQRTRVLEVDAVVLGTGYQQYL 356 Query: 317 --PFTKNLGLEELGIELDPRGRIPVNTRFQ 344 P L + D G + ++ ++ Sbjct: 357 IPPLLSGLQ---PWLAADVDGGLLIDRDYR 383 >2UZZ-A nrPDB Length = 372 Score = 40.3 bits (93), Expect = 0.002, Method: Composition-based stats. Identities = 9/34 (26%), Positives = 16/34 (47%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKN 73 + D+ +IGSG G A A + G + + + Sbjct: 1 MKYDLIIIGSGSVGAAAGYYATRAGLNVLMTDAH 34 >4MO2-B nrPDB Length = 368 Score = 39.9 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 13/39 (33%), Positives = 23/39 (58%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTC 80 D ++GSG G + A +A + G+ + +E+ E +GG C Sbjct: 2 YDYLIVGSGLFGSIFAYEATEKGYTCLVVEQREHIGGNC 40 >3KYB-A nrPDB Length = 390 Score = 39.9 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 12/42 (28%), Positives = 21/42 (50%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDM 255 +K++++GAG G +G G V ++ H+GG D Sbjct: 4 KKILIVGAGFSGAVIGRQLAEKGHQVHIIDQRDHIGGNSYDA 45 Score = 29.1 bits (64), Expect = 5.3, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 20/35 (57%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 + ++G+G G V + A+ G + I++ + +GG Sbjct: 6 ILIVGAGFSGAVIGRQLAEKGHQVHIIDQRDHIGG 40 >3UKH-A nrPDB Length = 519 Score = 39.9 bits (92), Expect = 0.003, Method: Composition-based stats. Identities = 18/43 (41%), Positives = 24/43 (55%), Gaps = 1/43 (2%) Query: 37 DQPIDADVTVIGSGPGGYVAAIKAAQL-GFKTVCIEKNETLGG 78 I DV VIG+GP G AA + Q+ G + ++ NET GG Sbjct: 2 HPDISVDVLVIGAGPTGLGAAKRLNQIDGPSWMIVDSNETPGG 44 >5MOG-A nrPDB Length = 497 Score = 39.5 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 13/46 (28%), Positives = 18/46 (39%) Query: 33 RTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 R V + G+G G A A G K + +E + LGG Sbjct: 9 RNSEQPTKPLQVVIAGAGLAGLSTAKYLADAGHKPILLEARDVLGG 54 >1VRQ-A nrPDB Length = 964 Score = 39.5 bits (91), Expect = 0.004, Method: Composition-based stats. Identities = 59/300 (19%), Positives = 100/300 (33%), Gaps = 55/300 (18%) Query: 35 YADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNN 94 Y + DV V+G+GP G AA +A++ G + + +++ GGT L Sbjct: 121 YDHVHVHTDVLVVGAGPAGLAAAREASRSGARVMLLDERPEAGGT-----------LREA 169 Query: 95 SHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLF---KQNKVVHVN 151 S G D A + V L E + G + Q + VH++ Sbjct: 170 S--GEQIDGIDAAQW---IDAVTEELAAAEETTHLQRTTVFGSYDANYILAAQRRTVHLD 224 Query: 152 G-YGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLK 210 G G+ + ++ I K +++AT + P D I+ A S++ Sbjct: 225 GPSGQGVSRERIW---------HIRAKQVVLATAAHERPIVFENNDRPGIML---AGSVR 272 Query: 211 KVPEKMVVIGAGVIGVE--------LGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQ 262 + V I V L S G V ++ IS Sbjct: 273 SYLNRFGVRAGSKIAVATTNDSVYPLVSELAASGGVVAVIDAR---------QNISAAAA 323 Query: 263 RILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAA-----SGGKAEVITCDVLLVCIGRRP 317 + + G + V + G++ + A + G+A+ DVL V G P Sbjct: 324 QAVTD-GVTVLTGSVVANTEADASGELSAVLVATLDEQRNLGEAQRFEADVLAVSGGFNP 382 >3ATQ-A nrPDB Length = 453 Score = 39.1 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 10/35 (28%), Positives = 18/35 (51%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNE 74 + DV +IG G G AA + ++ G K + ++ Sbjct: 5 LKYDVLIIGGGFAGSSAAYQLSRRGLKILLVDSKP 39 Score = 29.9 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 11/69 (15%), Positives = 21/69 (30%), Gaps = 3/69 (4%) Query: 209 LKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQR-ILQK 267 +K++ +++IG G G R G + V+ D + K Sbjct: 2 MKELKYDVLIIGGGFAGSSAAYQLSRRGLKILLVDSKPWNRIG--DKPCGDAVSKAHFDK 59 Query: 268 QGFKFKLNT 276 G + Sbjct: 60 LGMPYPKGE 68 >1QO8-A nrPDB Length = 566 Score = 39.1 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 11/37 (29%), Positives = 20/37 (54%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 V V+G+G G+ A++ A + G + ++K GG Sbjct: 122 TQVLVVGAGSAGFNASLAAKKAGANVILVDKAPFSGG 158 >2VOU-A nrPDB Length = 397 Score = 39.1 bits (90), Expect = 0.004, Method: Composition-based stats. Identities = 13/75 (17%), Positives = 27/75 (36%), Gaps = 3/75 (4%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISK--NFQRILQKQGFK 271 +++ V+G + G+ + + G DV E G I L +QG + Sbjct: 6 DRIAVVGGSISGLTAALMLRDAGVDVDVYERSPQ-PLSGFGTGIVVQPELVHYLLEQGVE 64 Query: 272 FKLNTKVTGATKKSD 286 + + + + D Sbjct: 65 LDSISVPSSSMEYVD 79 >1SEZ-A nrPDB Length = 504 Score = 39.1 bits (90), Expect = 0.005, Method: Composition-based stats. Identities = 13/35 (37%), Positives = 14/35 (40%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 V VIG+G G AA K G E GG Sbjct: 16 VAVIGAGVSGLAAAYKLKIHGLNVTVFEAEGKAGG 50 Score = 34.9 bits (79), Expect = 0.074, Method: Composition-based stats. Identities = 14/38 (36%), Positives = 20/38 (52%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGV 251 +++ VIGAGV G+ + G +VT E G GG Sbjct: 14 KRVAVIGAGVSGLAAAYKLKIHGLNVTVFEAEGKAGGK 51 >3IHG-A nrPDB Length = 535 Score = 38.8 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 12/36 (33%), Positives = 21/36 (58%) Query: 41 DADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETL 76 + DV V+G+G GG A+ A+ G + + +E+ L Sbjct: 5 EVDVLVVGAGLGGLSTAMFLARQGVRVLVVERRPGL 40 Score = 33.0 bits (74), Expect = 0.35, Method: Composition-based stats. Identities = 10/36 (27%), Positives = 16/36 (44%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGG 250 ++V+GAG+ G+ R G V VE + Sbjct: 7 DVLVVGAGLGGLSTAMFLARQGVRVLVVERRPGLSP 42 >5L46-A nrPDB Length = 841 Score = 38.8 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 24/115 (20%), Positives = 39/115 (33%), Gaps = 18/115 (15%) Query: 23 GLQGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFK-TVCIEKNETLGGTCL 81 G +G PL A+ +IG G G A A+ G K V +E Sbjct: 4 GREGEEKPPLSAETQWKDRAETVIIGGGCVGVSLAYHLAKAGMKDVVLLE---------- 53 Query: 82 NVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTG 136 K+ L +H A + GI + ++ + K+ E+ + G Sbjct: 54 -------KSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYEKLEEETGQVVG 101 >4Z2R-A nrPDB Length = 592 Score = 38.8 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 11/35 (31%), Positives = 22/35 (62%) Query: 41 DADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET 75 + DV ++G+GP G ++A A LG +++ I + + Sbjct: 12 ETDVLIVGAGPAGAMSATLLASLGIRSLMINRWRS 46 >4DGK-A nrPDB Length = 501 Score = 38.8 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 47/282 (16%), Positives = 80/282 (28%), Gaps = 56/282 (19%) Query: 46 VIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG----------------TCLNVGCIPSK 89 VIG+G GG AI+ G + +E+ + GG T + PS Sbjct: 6 VIGAGFGGLALAIRLQAAGIPVLLLEQRDKPGGRAYVYEDQGFTFDAGPTVITD---PSA 62 Query: 90 A--LLNNS-----HYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALT----GGI 138 L + Y + F E +V N D + ++ G Sbjct: 63 IEELFALAGKQLKEYVELLPVTPFYRLCWESGKV-FNYDNDQTRLEAQIQQFNPRDVEGY 121 Query: 139 AHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITIDED 198 ++ V GY K+ V + L A S + DE Sbjct: 122 RQFLDYSRAVFKEGYLKL---GTVPFLSFRDMLRAAPQLAKLQAWRSVYSKVASYIEDEH 178 Query: 199 TIVSSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHV----GGVGID 254 A S +++G S++ T + L G Sbjct: 179 L----RQAFSF-----HSLLVGGNPFAT--SSIY-------TLIHALEREWGVWFPRGGT 220 Query: 255 MEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAA 296 + + ++ Q G + LN +V+ + V +E Sbjct: 221 GALVQGMIKLFQDLGGEVVLNARVSHMETTGNKIEAVHLEDG 262 Score = 36.1 bits (82), Expect = 0.040, Method: Composition-based stats. Identities = 18/66 (27%), Positives = 23/66 (34%), Gaps = 10/66 (15%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFK 273 + VIGAG G+ L Q G V +E GG + + QGF F Sbjct: 2 KPTTVIGAGFGGLALAIRLQAAGIPVLLLEQRDKPGGRAY----------VYEDQGFTFD 51 Query: 274 LNTKVT 279 V Sbjct: 52 AGPTVI 57 >6BRD-A nrPDB Length = 476 Score = 38.0 bits (87), Expect = 0.009, Method: Composition-based stats. Identities = 28/174 (16%), Positives = 55/174 (31%), Gaps = 24/174 (13%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKN-------ETLGGTCLNVGCIPSKALLNN 94 DV V+G GP G + A + G + + +EK G L+V I + Sbjct: 2 FDVIVVGGGPTGLMLAGELRLHGVRVLVLEKETEPTRQSRAQG---LHVRSIE--VMAQR 56 Query: 95 SHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQN-----KVVH 149 + G + + + + ++ + V A+ I Sbjct: 57 GLLERFLERGHTVAVGGFFAGLATSWPERLDTAHSYVLAVPQVITEQLLAEHATALGAEI 116 Query: 150 VNGYGKI---TGKNQVTATKADGGTQVIDTKNILIATGSE--VTPFPGITIDED 198 G + ++ VT ADG + + + ++ G V G+ + Sbjct: 117 RRGRALVGLRQDEDGVTVDLADG--EQLRARYVVGCDGGRSTVRKLLGVAFPGE 168 Score = 29.9 bits (66), Expect = 3.1, Method: Composition-based stats. Identities = 8/29 (27%), Positives = 14/29 (48%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVE 243 ++V+G G G+ L + G V +E Sbjct: 3 DVIVVGGGPTGLMLAGELRLHGVRVLVLE 31 >1F14-A nrPDB Length = 310 Score = 38.0 bits (87), Expect = 0.010, Method: Composition-based stats. Identities = 17/100 (17%), Positives = 34/100 (34%), Gaps = 7/100 (7%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFK 273 + + VIG G++G + V G V V+ + K + L+K K K Sbjct: 16 KHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKS-----KKGIEESLRKVAKK-K 69 Query: 274 LNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCI 313 + + + + V + D+++ I Sbjct: 70 FAENPKAGDECVEKTLSTIATSTDAASV-VHSTDLVVEAI 108 >6MO6-A nrPDB Length = 414 Score = 37.6 bits (86), Expect = 0.013, Method: Composition-based stats. Identities = 35/180 (19%), Positives = 62/180 (34%), Gaps = 25/180 (13%) Query: 258 SKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRP 317 + Q I+Q++ + ++D + V G+ +VI+ ++L V P Sbjct: 203 ADALQEIIQERNLTVNYKKNL--IEVRADKQEAVFENLDKPGETQVISYEMLHVT----P 256 Query: 318 FTKNLGLEELGIELDPRGRIPVNTR--FQTKIPNIYAIGDVVAGP---MLAHKAEDEGI- 371 + + D G + V+ + PN++ IGD P A A GI Sbjct: 257 PMSPPDVLKTSPVADAAGWVDVDKETLQHRRYPNVFGIGDCTNLPTSKTAAAVAAQSGIL 316 Query: 372 -----ICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVGKSEEQLKEEGIEYKVGKFPFAAN 426 + ++ + Y P V V +E K E +E FPF + Sbjct: 317 DRTISVIMKNQTPTKKYDGYTSCPLVT----GYNRVILAEFDYKAEPLE----TFPFDQS 368 >6HNS-A nrPDB Length = 454 Score = 37.6 bits (86), Expect = 0.014, Method: Composition-based stats. Identities = 38/240 (15%), Positives = 72/240 (30%), Gaps = 59/240 (24%) Query: 40 IDADVTVIGSGPGGYV---AAIKAAQLGF---KTVCIEKNETLGGTCLNVGCIPSKALLN 93 ++ V +IG+GP G A AA G + VC EK GG + N Sbjct: 1 MNTRVAIIGAGPCGLAQLRAFQSAAAKGAAIPELVCFEKQSDWGG------------MWN 48 Query: 94 NS------HYYHMAHGKDFASRG-------IEMSEVRLN----------------LDKMM 124 + + HG + +E ++ + D + Sbjct: 49 YTWRTGVDEHGEPVHGSMYRYLWSNGPKECLEFADYTFDEHFGRPIGSYPPREVLWDYIK 108 Query: 125 EQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATK-ADGGTQVIDTKNILIAT 183 + A + I +V + G VT ++ ++ A Sbjct: 109 GRVEKA--GVRDYIRFNTAVRQVSYDETSGLF----SVTVQDHSNNRVYTETFDYVVNAC 162 Query: 184 G----SEVTPFPGITIDEDTIVSSTGALS-LKKVPEKMVVIGAGVIGVELGSVWQRLGAD 238 G F G ++ + L+ + ++V+G+ ++GS + GA Sbjct: 163 GHFSTPNTPYFEGFERFGGRVLHAHDFRDALEFKDKDILVVGSSYSAEDIGSQCYKYGAR 222 Score = 33.0 bits (74), Expect = 0.32, Method: Composition-based stats. Identities = 20/89 (22%), Positives = 35/89 (39%), Gaps = 6/89 (6%) Query: 237 ADVTAVEFLGHVGGVGIDMEIS-KNFQRILQKQGFK--FKLNTKVTGATK-KSDGKIDVS 292 AD T E G G E+ + ++K G + + NT V + ++ G V+ Sbjct: 82 ADYTFDEHFGRPIGSYPPREVLWDYIKGRVEKAGVRDYIRFNTAVRQVSYDETSGLFSVT 141 Query: 293 IEAASGGKAEVITCDVLLVCIGR--RPFT 319 ++ S + T D ++ G P T Sbjct: 142 VQDHSNNRVYTETFDYVVNACGHFSTPNT 170 >4A6N-B nrPDB Length = 398 Score = 37.6 bits (86), Expect = 0.014, Method: Composition-based stats. Identities = 12/60 (20%), Positives = 25/60 (41%), Gaps = 3/60 (5%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEIS---KNFQRILQKQGF 270 + + +IG G +G+ + + Q+ G DV+ E + + Q ++K G Sbjct: 27 KNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARIFGGTLDLHKGSGQEAMKKAGL 86 Score = 34.1 bits (77), Expect = 0.13, Method: Composition-based stats. Identities = 16/55 (29%), Positives = 23/55 (41%), Gaps = 5/55 (9%) Query: 30 VPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKN-----ETLGGT 79 VP ++ + D +V +IG GP G A Q G E++ GGT Sbjct: 15 VPRGSHMNLLSDKNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARIFGGT 69 >3HDH-A nrPDB Length = 302 Score = 37.2 bits (85), Expect = 0.016, Method: Composition-based stats. Identities = 17/100 (17%), Positives = 34/100 (34%), Gaps = 7/100 (7%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFK 273 + + VIG G++G + V G V V+ + K + L+K K K Sbjct: 16 KHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKS-----KKGIEESLRKVAKK-K 69 Query: 274 LNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCI 313 + + + + V + D+++ I Sbjct: 70 FAENPKAGDEFVEKTLSSISTSTDAASV-VHSTDLVVEAI 108 >2VHY-A nrPDB Length = 377 Score = 37.2 bits (85), Expect = 0.017, Method: Composition-based stats. Identities = 13/31 (41%), Positives = 17/31 (54%) Query: 41 DADVTVIGSGPGGYVAAIKAAQLGFKTVCIE 71 ADV VIG+G GY AA A +G ++ Sbjct: 168 PADVVVIGAGTAGYNAARIANGMGATVTVLD 198 Score = 32.2 bits (72), Expect = 0.61, Method: Composition-based stats. Identities = 24/114 (21%), Positives = 38/114 (33%), Gaps = 17/114 (14%) Query: 167 ADGGTQVIDTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKK--------------- 211 D GT I + + A G+ P + + + GA L + Sbjct: 108 LDSGTTSIAYETVQTADGALPLLAPMSEVAG-RLAAQVGAYHLMRTQGGRGVLMGGVPGV 166 Query: 212 VPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRIL 265 P +VVIGAG G + +GA VT ++ + +D E Sbjct: 167 EPADVVVIGAGTAGYNAARIANGMGATVTVLD-INIDKLRQLDAEFCGRIHTRY 219 >4IV9-A nrPDB Length = 557 Score = 36.8 bits (84), Expect = 0.020, Method: Composition-based stats. Identities = 13/56 (23%), Positives = 24/56 (42%), Gaps = 1/56 (1%) Query: 215 KMVVIGAGVIGVELGSVWQRLGA-DVTAVEFLGHVGGVGIDMEISKNFQRILQKQG 269 ++ ++GAG+ G+ + R G DV E +GG + R + + G Sbjct: 40 RVAIVGAGISGLVAATELLRAGVKDVVLYESRDRIGGRVWSQVFDQTRPRYIAEMG 95 Score = 32.6 bits (73), Expect = 0.44, Method: Composition-based stats. Identities = 13/36 (36%), Positives = 20/36 (55%), Gaps = 1/36 (2%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFK-TVCIEKNETLGG 78 V ++G+G G VAA + + G K V E + +GG Sbjct: 41 VAIVGAGISGLVAATELLRAGVKDVVLYESRDRIGG 76 >3WE0-A nrPDB Length = 580 Score = 36.8 bits (84), Expect = 0.020, Method: Composition-based stats. Identities = 17/53 (32%), Positives = 30/53 (56%), Gaps = 6/53 (11%) Query: 26 GLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 GL ++P + ++ V ++G+G G VAA + +LG K V E ++ +GG Sbjct: 55 GLGSIPAARHGEE-----VAIVGAGIAGLVAAYELMKLGLKPVVYEASK-MGG 101 >4EIQ-A nrPDB Length = 549 Score = 36.8 bits (84), Expect = 0.021, Method: Composition-based stats. Identities = 12/45 (26%), Positives = 23/45 (51%) Query: 30 VPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNE 74 VP ++ + PI+ DV ++G GP G A+ A + ++ + Sbjct: 15 VPRGSHMNAPIETDVLILGGGPVGMALALDLAHRQVGHLVVDAGD 59 >6C6P-A nrPDB Length = 458 Score = 36.8 bits (84), Expect = 0.025, Method: Composition-based stats. Identities = 12/29 (41%), Positives = 19/29 (65%) Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEF 244 ++++GAGV+G L +V R G VT +E Sbjct: 10 VIIVGAGVLGSALAAVLSRDGRKVTVIER 38 >3S61-A nrPDB Length = 463 Score = 36.8 bits (84), Expect = 0.025, Method: Composition-based stats. Identities = 45/254 (17%), Positives = 74/254 (29%), Gaps = 63/254 (24%) Query: 161 QVTATKADGGTQVIDTKNILIATGSEVTPFPGI----TIDEDTIVSSTGALSLKKVP--- 213 +V + ADG V T+ ++++ G P + D S + K P Sbjct: 166 RVISRNADGEELVRTTRALVVSPGG-TPRIPQVFRALKGDGRVFHHSQYLEHMAKQPCSS 224 Query: 214 ---EKMVVIGAGVIGVEL------------------GSVWQRLGAD-----------VTA 241 K+ +IG G E S + Sbjct: 225 GKPMKIAIIGGGQSAAEAFIDLNDSYPSVQADMILRASALKPADDSPFVNEVFAPKFTDL 284 Query: 242 V----EFLGHVGGVGI--------DMEISKNFQRILQKQGFK------FKLNTKVTGATK 283 + D ++ + + +Q F+ T V AT Sbjct: 285 IYSREHAERERLLREYHNTNYSVVDTDLIERIYGVFYRQKVSGIPRHAFRCMTTVERATA 344 Query: 284 KSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRF 343 + G I++++ A G+ V T D +++ G LE L L I + R Sbjct: 345 TAQG-IELALRDAGSGELSVETYDAVILATGYERQLHRQLLEPLAEYLGDH-EIGRDYRL 402 Query: 344 QTKIP---NIYAIG 354 QT IYA G Sbjct: 403 QTDERCKVAIYAQG 416 >5KXJ-A nrPDB Length = 557 Score = 36.4 bits (83), Expect = 0.030, Method: Composition-based stats. Identities = 24/147 (16%), Positives = 48/147 (32%), Gaps = 24/147 (16%) Query: 234 RLGADVTAVEFLGHVGGVGIDMEISKNF-QRILQKQGFKFKLNTK---VTGATKKSDGKI 289 R G V +EF + L+ +G K + ++ + Sbjct: 230 RAGCRVANLEFNQFHPTALYHPQARNFLLTEALRGEGAYLKRPDGSRFMPDVDERGELAP 289 Query: 290 DVSIEAASGGKAEVITCDVLLVCIGRRPFT--------KNLGLEELGIELDPR------- 334 + A + + + D + + I +P L +LG++L Sbjct: 290 RDIVARAIDHEMKQLGADCMFLDISHKPDDFVRQHFPMIYAKLLDLGMDLTKEPIPVVPA 349 Query: 335 -----GRIPVNTRFQTKIPNIYAIGDV 356 G + V+ +T + +YAIG+V Sbjct: 350 AHYTCGGVVVDDYGRTDVDGLYAIGEV 376 Score = 34.5 bits (78), Expect = 0.12, Method: Composition-based stats. Identities = 11/32 (34%), Positives = 17/32 (53%), Gaps = 1/32 (3%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNE 74 DV +IGSG G A++ A+ K + + K Sbjct: 10 DVLIIGSGAAGLSLALRLAEKH-KVIVLSKGP 40 >4MOP-A nrPDB Length = 633 Score = 36.4 bits (83), Expect = 0.030, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 17/35 (48%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNE 74 I DV ++GSGP G A + G+K + E Sbjct: 45 IKYDVVIVGSGPIGCTYARELVGAGYKVAMFDIGE 79 Score = 28.7 bits (63), Expect = 5.7, Method: Composition-based stats. Identities = 11/39 (28%), Positives = 16/39 (41%), Gaps = 5/39 (12%) Query: 210 KKVPE-----KMVVIGAGVIGVELGSVWQRLGADVTAVE 243 KKVP +V++G+G IG G V + Sbjct: 38 KKVPGMDIKYDVVIVGSGPIGCTYARELVGAGYKVAMFD 76 >2ZXH-A nrPDB Length = 637 Score = 36.4 bits (83), Expect = 0.031, Method: Composition-based stats. Identities = 37/157 (23%), Positives = 61/157 (38%), Gaps = 19/157 (12%) Query: 41 DADVTVIGSGPGGYVAAIKAAQLGFKTVC-IEKNETLGGTCLN--VGCIPSKALLNNSHY 97 + DV VIG G G AA+ AA++G KT + +T+G N +G I ++ Sbjct: 27 EFDVVVIGGGHAGIEAALAAARMGAKTAMFVLNADTIGQMSCNPAIGGIAKGIVVREIDA 86 Query: 98 YHMAHGKDFASRGIEM------SEVRLNLDKMMEQKSTAVKALTGGIAHL----FKQNKV 147 GK GI+ + + K + + + KQ +V Sbjct: 87 LGGEMGKAIDQTGIQFKMLNTRKGKAVQSPRAQADKKRYREYMKKVCENQENLYIKQEEV 146 Query: 148 VHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATG 184 V + I NQV + + G + TK +++ TG Sbjct: 147 VDI-----IVKNNQVVGVRTNLGVE-YKTKAVVVTTG 177 >1RP0-A nrPDB Length = 284 Score = 36.4 bits (83), Expect = 0.031, Method: Composition-based stats. Identities = 15/50 (30%), Positives = 24/50 (48%), Gaps = 4/50 (8%) Query: 33 RTYADQPIDA---DVTVIGSGPGGYVAAIKAAQL-GFKTVCIEKNETLGG 78 R Y I DV V+G+G G AA + ++ + IE++ + GG Sbjct: 28 RRYMTDMITYAETDVVVVGAGSAGLSAAYEISKNPNVQVAIIEQSVSPGG 77 >6ACQ-A nrPDB Length = 302 Score = 36.1 bits (82), Expect = 0.037, Method: Composition-based stats. Identities = 16/72 (22%), Positives = 34/72 (47%), Gaps = 3/72 (4%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGID---MEISKNFQRILQKQGF 270 +K+ VIGAG +G + + G +V + G+D +SK ++ ++ Sbjct: 22 KKVCVIGAGTMGSGIAQAFAAKGFEVVLRDIKDEFVDRGLDFINKNLSKLVKKGKIEEAT 81 Query: 271 KFKLNTKVTGAT 282 K ++ T+++G Sbjct: 82 KVEILTRISGTV 93 >1C0L-A nrPDB Length = 363 Score = 36.1 bits (82), Expect = 0.038, Method: Composition-based stats. Identities = 10/31 (32%), Positives = 18/31 (58%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEF 244 +++VV+G+GVIG+ + R G V + Sbjct: 7 KRVVVLGSGVIGLSSALILARKGYSVHILAR 37 >4RPJ-A nrPDB Length = 399 Score = 36.1 bits (82), Expect = 0.039, Method: Composition-based stats. Identities = 13/38 (34%), Positives = 21/38 (55%), Gaps = 1/38 (2%) Query: 42 ADVTVIGSGPGGYVAAIK-AAQLGFKTVCIEKNETLGG 78 D+ V+GSG G A + A QL + + +E+ +GG Sbjct: 8 FDLFVVGSGFFGLTIAERVATQLDKRVLVLERRPHIGG 45 Score = 29.5 bits (65), Expect = 3.8, Method: Composition-based stats. Identities = 11/40 (27%), Positives = 19/40 (47%), Gaps = 1/40 (2%) Query: 215 KMVVIGAGVIGVELGS-VWQRLGADVTAVEFLGHVGGVGI 253 + V+G+G G+ + V +L V +E H+GG Sbjct: 9 DLFVVGSGFFGLTIAERVATQLDKRVLVLERRPHIGGNAY 48 >6H3G-A nrPDB Length = 651 Score = 36.1 bits (82), Expect = 0.041, Method: Composition-based stats. Identities = 14/38 (36%), Positives = 17/38 (44%), Gaps = 2/38 (5%) Query: 38 QPIDADVTVIGSGPGGYVAAIKAAQLG--FKTVCIEKN 73 P + DV V G GP G V A + A K + IE Sbjct: 3 HPEEVDVIVCGGGPAGCVVAGRLAYADPTLKVMLIEGG 40 >4H7U-A nrPDB Length = 602 Score = 35.7 bits (81), Expect = 0.048, Method: Composition-based stats. Identities = 11/37 (29%), Positives = 18/37 (48%), Gaps = 1/37 (2%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQ-LGFKTVCIEKNET 75 +D D V G G G V A + ++ +K + IE + Sbjct: 39 VDYDFIVAGGGTAGLVVASRLSENSNWKVLVIEAGPS 75 >3G5Q-A nrPDB Length = 443 Score = 35.7 bits (81), Expect = 0.051, Method: Composition-based stats. Identities = 12/39 (30%), Positives = 16/39 (41%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVG 252 E++ V+GAG+ G E RLG V E Sbjct: 2 ERVNVVGAGLAGSEAAWTLLRLGVPVRLFEMRPKRMTPA 40 >3BI4-A nrPDB Length = 516 Score = 35.3 bits (80), Expect = 0.064, Method: Composition-based stats. Identities = 13/39 (33%), Positives = 22/39 (56%), Gaps = 1/39 (2%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGA-DVTAVEFLGHVGGV 251 +K+++IGAG+ G++ S + G D +E VGG Sbjct: 9 KKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGR 47 Score = 33.0 bits (74), Expect = 0.34, Method: Composition-based stats. Identities = 13/42 (30%), Positives = 20/42 (47%), Gaps = 1/42 (2%) Query: 38 QPIDADVTVIGSGPGGYVAAIKAAQLGFK-TVCIEKNETLGG 78 P V +IG+G G AA Q G + + +E + +GG Sbjct: 5 SPAKKKVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGG 46 >5AYV-A nrPDB Length = 309 Score = 35.3 bits (80), Expect = 0.070, Method: Composition-based stats. Identities = 21/113 (18%), Positives = 40/113 (35%), Gaps = 29/113 (25%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL 274 ++ V+GAG IG G++ R G DVT + V + K G Sbjct: 2 RIYVLGAGSIGSLFGALLARAGNDVTLIGRREQV--------------DAINKNGLHVF- 46 Query: 275 NTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEEL 327 G + +++ + A D+L++ + + ++ LE Sbjct: 47 ------------GAEEFTVKPKATIYAPEEPPDLLILAV--KSYSTKTALECA 85 >3SM8-A nrPDB Length = 381 Score = 34.5 bits (78), Expect = 0.10, Method: Composition-based stats. Identities = 13/39 (33%), Positives = 19/39 (48%), Gaps = 1/39 (2%) Query: 39 PIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLG 77 PI+AD VIG+G G + G + V +E+ G Sbjct: 7 PIEADYLVIGAGIAGASTGYWLSAHG-RVVVLEREAQPG 44 >1KSU-A nrPDB Length = 571 Score = 34.5 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 25/150 (16%), Positives = 47/150 (31%), Gaps = 26/150 (17%) Query: 233 QRLGADVTAVEFL---------GHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATK 283 +GAD+T V + GG G+ + + K+ ++NT+ K Sbjct: 224 TAMGADLTDVGMMGGASVNRAHRPTGGAGVGAHVVQVLYDNAVKRNIDLRMNTRGIEVLK 283 Query: 284 KSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRF 343 G + + + D +++ G ++ +G I Sbjct: 284 DDKGTVKGILVKGMYKGYYWVKADAVILATGGFAKNNE---RVAKLDPSLKGFI------ 334 Query: 344 QTKIPNIYAIGDVVAGPMLAHKAEDEGIIC 373 T P A+GD + AE+ G Sbjct: 335 STNQPG--AVGDGLD------VAENAGGAL 356 >6HRD-A nrPDB Length = 317 Score = 34.5 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 16/105 (15%), Positives = 34/105 (32%), Gaps = 8/105 (7%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEI--------SKNFQRIL 265 +++ V+GAG +G + V R G +VT E + G + + + Sbjct: 26 QRVGVVGAGQMGSGIAEVSARAGVEVTVFEPAEALITAGRNRIVKSLERAVSAGKVTERE 85 Query: 266 QKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLL 310 + + T I+ +E + D ++ Sbjct: 86 RDRALGLLTFTTDLNDLSDRQLVIEAVVEDEAVKSEIFAELDRVV 130 >3COX-A nrPDB Length = 507 Score = 34.5 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 14/32 (43%), Positives = 18/32 (56%) Query: 45 TVIGSGPGGYVAAIKAAQLGFKTVCIEKNETL 76 VIGSG GG VAA++ Q G T +E + Sbjct: 15 LVIGSGYGGAVAALRLTQAGIPTQIVEMGRSW 46 >1D4E-A nrPDB Length = 572 Score = 34.5 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 19/92 (20%), Positives = 37/92 (40%), Gaps = 9/92 (9%) Query: 232 WQRLGADVTAVEFL---------GHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGAT 282 +GAD+T V + GG G+ +++ K+G +LN++V Sbjct: 223 LTSMGADMTDVGRMGGASVNRSHRPTGGAGVGAHVAQVLWDNAVKRGTDIRLNSRVVRIL 282 Query: 283 KKSDGKIDVSIEAASGGKAEVITCDVLLVCIG 314 + + GK+ + VI D +++ G Sbjct: 283 EDASGKVTGVLVKGEYTGYYVIKADAVVIAAG 314 >2QA2-A nrPDB Length = 499 Score = 34.5 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 22/108 (20%), Positives = 38/108 (35%), Gaps = 8/108 (7%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL 274 ++V+GAG G+ L + G DV +E L G + + + ++G Sbjct: 14 SVIVVGAGPAGLMLAGELRLGGVDVMVLEQLPQRTGESRGLGFTARTMEVFDQRGI-LPA 72 Query: 275 NTKVTGATKKSDGKIDVSIEAASG-----GKAEVITCDVLL--VCIGR 315 V +T+ G V G T + +L +GR Sbjct: 73 FGPVETSTQGHFGGRPVDFGVLEGAHYGVKAVPQSTTESVLEEWALGR 120 Score = 28.4 bits (62), Expect = 8.8, Method: Composition-based stats. Identities = 11/31 (35%), Positives = 17/31 (54%) Query: 41 DADVTVIGSGPGGYVAAIKAAQLGFKTVCIE 71 DA V V+G+GP G + A + G + +E Sbjct: 12 DASVIVVGAGPAGLMLAGELRLGGVDVMVLE 42 >3HWR-A nrPDB Length = 318 Score = 34.5 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 20/99 (20%), Positives = 40/99 (40%), Gaps = 25/99 (25%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL 274 K+ ++GAG +G G + R G +V + HV + ++ G + + Sbjct: 21 KVAIMGAGAVGCYYGGMLARAGHEVILIARPQHV--------------QAIEATGLRLET 66 Query: 275 NTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCI 313 + D ++ V +AS + V D++L C+ Sbjct: 67 QSF--------DEQVKV---SASSDPSAVQGADLVLFCV 94 >1DOD-A nrPDB Length = 394 Score = 34.5 bits (78), Expect = 0.12, Method: Composition-based stats. Identities = 12/55 (21%), Positives = 23/55 (41%), Gaps = 6/55 (10%) Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEF------LGHVGGVGIDMEISKNFQRI 264 + +IGAG G+ LG + + G D +E LG + ++ + + Sbjct: 5 VAIIGAGPSGLLLGQLLHKAGIDNVILERQTPDYVLGRIRAGVLEQGMVDLLREA 59 >5X6R-A nrPDB Length = 420 Score = 34.5 bits (78), Expect = 0.12, Method: Composition-based stats. Identities = 13/84 (15%), Positives = 30/84 (35%), Gaps = 1/84 (1%) Query: 200 IVSSTGALSLK-KVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEIS 258 I ++ + + E + +IGAG++G + + G +VT +F + Sbjct: 14 IPTTENLYYFQGSMSESVAIIGAGLVGCLAALAFSKEGYNVTLYDFRQDPRLDTTKNKNL 73 Query: 259 KNFQRILQKQGFKFKLNTKVTGAT 282 K+ + +G + Sbjct: 74 KSINLAISARGIDALKSIDPDACE 97 >3CP8-A nrPDB Length = 641 Score = 34.1 bits (77), Expect = 0.13, Method: Composition-based stats. Identities = 11/29 (37%), Positives = 16/29 (55%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCI 70 DV V+G+G G AA+ A+ G + I Sbjct: 22 YDVIVVGAGHAGCEAALAVARGGLHCLLI 50 >1KNR-A nrPDB Length = 540 Score = 34.1 bits (77), Expect = 0.13, Method: Composition-based stats. Identities = 8/22 (36%), Positives = 14/22 (63%) Query: 335 GRIPVNTRFQTKIPNIYAIGDV 356 G + V+ +T + +YAIG+V Sbjct: 355 GGVMVDDHGRTDVEGLYAIGEV 376 Score = 32.6 bits (73), Expect = 0.44, Method: Composition-based stats. Identities = 13/37 (35%), Positives = 17/37 (45%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGT 79 DV +IGSG G A++ A V + T G T Sbjct: 10 DVLIIGSGAAGLSLALRLADQHQVIVLSKGPVTEGST 46 >4K2X-A nrPDB Length = 523 Score = 34.1 bits (77), Expect = 0.15, Method: Composition-based stats. Identities = 10/33 (30%), Positives = 19/33 (57%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEK 72 + DV + G+GP G + A + G +T+ +E+ Sbjct: 21 MRYDVVIAGAGPTGLMLACELRLAGARTLVLER 53 >3OZ2-A nrPDB Length = 397 Score = 34.1 bits (77), Expect = 0.15, Method: Composition-based stats. Identities = 11/23 (47%), Positives = 14/23 (60%) Query: 55 VAAIKAAQLGFKTVCIEKNETLG 77 AA AA+ G KT+ IEK +G Sbjct: 18 TAARYAAKYGLKTLMIEKRPEIG 40 >4B68-A nrPDB Length = 501 Score = 34.1 bits (77), Expect = 0.15, Method: Composition-based stats. Identities = 22/136 (16%), Positives = 41/136 (30%), Gaps = 20/136 (14%) Query: 142 FKQNKVVHVNGYG----KITGKNQVTATKADGGTQVID-TKNILIATGSEVTPFPGITID 196 + + V + G + V + + G T+ ++IA G G+ D Sbjct: 164 YGEEVVEVIPGKSDPSSSVVDFFTVRSRNVETGEISARRTRKVVIAIGGTAKMPSGLPQD 223 Query: 197 EDTIVSSTGALSLKKV------PEKMVVIGAGVIGVELGSVWQRL-----GADVTAVEFL 245 I SS +L + P + V+G+G E ++ L + T + Sbjct: 224 PRIIHSSKYCTTLPALLKDKSKPYNIAVLGSGQSAAE---IFHDLQKRYPNSRTTLI-MR 279 Query: 246 GHVGGVGIDMEISKNF 261 D Sbjct: 280 DSAMRPSDDSPFVNEI 295 >6J0Z-C nrPDB Length = 491 Score = 34.1 bits (77), Expect = 0.16, Method: Composition-based stats. Identities = 12/64 (18%), Positives = 22/64 (34%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFK 273 +VV+GAG G+ L + G V ++ L + S ++G + Sbjct: 6 SDVVVVGAGPTGLMLAGELRLAGVSVVVLDKLAEPIKESRALGFSARTIEEFAQRGLMDR 65 Query: 274 LNTK 277 Sbjct: 66 FGEV 69 Score = 33.0 bits (74), Expect = 0.30, Method: Composition-based stats. Identities = 36/205 (17%), Positives = 69/205 (33%), Gaps = 28/205 (13%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEK-------NETLGGTCLNVGCIPSKALL 92 D+DV V+G+GP G + A + G V ++K + LG + + + L+ Sbjct: 4 YDSDVVVVGAGPTGLMLAGELRLAGVSVVVLDKLAEPIKESRALGFSARTIEEFAQRGLM 63 Query: 93 NNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLF-----KQNKV 147 + + F ++ + + + GG A + +V Sbjct: 64 DRFGEVGVIPVGHFGGVPLDYQVIEGGSYGARGIPQARTEGILGGWARELGAEVRRGYEV 123 Query: 148 VHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVT-------PFPGITIDEDT- 199 + G V A ADG + + ++ G+ + FPG + Sbjct: 124 TAIEDTGTSV---TVEAAGADGSPLSLRARYVVGCDGARSSVRKLAGIDFPGTEPAIELR 180 Query: 200 -----IVSSTGALSLKKVPEKMVVI 219 V S ++VP MV++ Sbjct: 181 FADVAGVQLRPRFSGERVPGGMVMV 205 >5XGV-A nrPDB Length = 462 Score = 33.8 bits (76), Expect = 0.17, Method: Composition-based stats. Identities = 9/57 (15%), Positives = 20/57 (35%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGF 270 + +++ G G +G+ L G D +E I+ + ++G Sbjct: 2 DTVIIAGGGPVGLMLACELGLAGVDTVVLERHDAPREPSRGGAINATVVELFTQRGI 58 >2E5V-A nrPDB Length = 472 Score = 33.8 bits (76), Expect = 0.18, Method: Composition-based stats. Identities = 72/387 (18%), Positives = 113/387 (29%), Gaps = 77/387 (19%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHG 103 + +IGSG G A + + G K I K G T + G + + ++S H Sbjct: 2 IYIIGSGIAGLSAGVALRRAGKKVTLISKRIDGGSTPIAKGGVAASVGSDDSPELHAQDT 61 Query: 104 ------------------------KDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIA 139 + F S G E E +L V T Sbjct: 62 IRVGDGLCDVKTVNYVTSEAKNVIETFESWGFEFEE---DLRLEGGHTKRRVLHRTDETG 118 Query: 140 HLFKQNKVVHVNGYG-KITGKNQVTATKADGGTQ---------VIDTKNILIATGSEVTP 189 + G I V DG V D +++ATG Sbjct: 119 REIFNFLLKLAREEGIPIIEDRLVEIRVKDGKVTGFVTEKRGLVEDVDKLVLATGG---- 174 Query: 190 FPGITIDEDTIVSSTGALSLKKVPEKMVVIGAG-VIGVELGSVWQRL---GADVTAVEFL 245 SST + + IG G I + G++ + T Sbjct: 175 -----YSYLYEYSSTQSTN----------IGDGMAIAFKAGTILADMEFVQFHPTVTSLD 219 Query: 246 GHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSD-GKIDVSIEAASGGKAEVI 304 G V + + +I+ + G +F N G D + IE G K + Sbjct: 220 GEVFL--LTETLRGEGAQIINENGERFLFNYDKRGELAPRDILSRAIYIEMLKGHKVFID 277 Query: 305 ---------TCDVLLVCIGRRPFTKNLGLEELGIELDPRGRIPVNTRFQTKIPNIYAIGD 355 V+ + R + + G I VN R ++ I N+YAIG+ Sbjct: 278 LSKIEDFERKFPVVAKYLARHGHNYKVKIPIFPAAHFVDGGIRVNIRGESNIVNLYAIGE 337 Query: 356 VV-----AGPMLAHKAEDEGIICVEGM 377 V LA + EG++ + Sbjct: 338 VSDSGLHGANRLASNSLLEGLVFGINL 364 >4P9S-A nrPDB Length = 848 Score = 33.8 bits (76), Expect = 0.19, Method: Composition-based stats. Identities = 23/118 (19%), Positives = 40/118 (33%), Gaps = 21/118 (17%) Query: 21 SHGL-QGLSAVPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFK-TVCIEKNETLGG 78 S GL +G + P + +IG G G A A+ G + V +E Sbjct: 4 SAGLREGQESPPSPPEWKDRAET--VIIGGGCVGVSLAYHLAKAGMRDVVLLE------- 54 Query: 79 TCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVKALTG 136 K+ L +H A + GI + ++ + K+ E+ + G Sbjct: 55 ----------KSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIKLYERLEEETGQVVG 102 >5KOX-A nrPDB Length = 476 Score = 33.8 bits (76), Expect = 0.20, Method: Composition-based stats. Identities = 13/33 (39%), Positives = 18/33 (54%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET 75 DV + G GP G + A + G +TV +EK T Sbjct: 6 DVIIAGGGPTGLMLAGELRLHGVRTVVLEKEPT 38 >2GRJ-A nrPDB Length = 192 Score = 33.4 bits (75), Expect = 0.23, Method: Composition-based stats. Identities = 16/80 (20%), Positives = 33/80 (41%), Gaps = 7/80 (8%) Query: 221 AGVIGVELGSVWQRLGAD------VTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL 274 +G+I +E ++ +R+G D +T V + + + FQ + QG Sbjct: 111 SGLIVIE-AALLKRMGLDQLCDHVITVVASRETILKRNREADRRLKFQEDIVPQGIVVAN 169 Query: 275 NTKVTGATKKSDGKIDVSIE 294 N+ + KK + + + E Sbjct: 170 NSTLEDLEKKVEEVMKLVWE 189 >2DKH-A nrPDB Length = 639 Score = 33.4 bits (75), Expect = 0.24, Method: Composition-based stats. Identities = 17/45 (37%), Positives = 22/45 (48%), Gaps = 2/45 (4%) Query: 31 PLRTYADQPIDADVTVIGSGPGGYV-AAIKAAQLGFKTVCIEKNE 74 P T A P DV ++G GP G AA AA +T +E+ E Sbjct: 23 PAHTEA-VPSQVDVLIVGCGPAGLTLAAQLAAFPDIRTCIVEQKE 66 >5I68-A nrPDB Length = 663 Score = 33.4 bits (75), Expect = 0.24, Method: Composition-based stats. Identities = 12/39 (30%), Positives = 16/39 (41%), Gaps = 2/39 (5%) Query: 39 PIDADVTVIGSGPGGYVAAIKAA--QLGFKTVCIEKNET 75 P + D+ V+G G G A + A K IE E Sbjct: 4 PEEFDILVLGGGSSGSCIAGRLANLDHSLKVGLIEAGEN 42 >1LTX-R nrPDB Length = 650 Score = 33.4 bits (75), Expect = 0.25, Method: Composition-based stats. Identities = 14/41 (34%), Positives = 22/41 (53%), Gaps = 2/41 (4%) Query: 39 PIDADVTVIGSG-PGGYVAAIKAAQLGFKTVCIEKNETLGG 78 P D DV VIG+G P +AA ++ G + + ++ GG Sbjct: 6 PSDFDVIVIGTGLPESIIAAA-CSRSGQRVLHVDSRSYYGG 45 >4UIR-A nrPDB Length = 646 Score = 33.4 bits (75), Expect = 0.26, Method: Composition-based stats. Identities = 16/64 (25%), Positives = 25/64 (39%), Gaps = 5/64 (7%) Query: 256 EISKNFQRILQKQGFKFKLNTKVTGAT--KKSDGKIDVSIEAASGGKAEVITC---DVLL 310 ++ LQ++G LNT V ++GK+ I GK I D ++ Sbjct: 268 TFVTPLRKFLQEKGVNIHLNTLVKDLDIHINTEGKVVEGIITEQDGKEVKIPVGKNDYVI 327 Query: 311 VCIG 314 V G Sbjct: 328 VTTG 331 >3FPZ-A nrPDB Length = 326 Score = 33.4 bits (75), Expect = 0.26, Method: Composition-based stats. Identities = 13/38 (34%), Positives = 18/38 (47%), Gaps = 2/38 (5%) Query: 43 DVTVIGSGPGGYVAAIKAAQL--GFKTVCIEKNETLGG 78 DV ++G+G G AA A+ K IE + GG Sbjct: 67 DVIIVGAGSSGLSAAYVIAKNRPDLKVCIIESSVAPGG 104 >4IVM-B nrPDB Length = 483 Score = 33.4 bits (75), Expect = 0.27, Method: Composition-based stats. Identities = 13/37 (35%), Positives = 19/37 (51%), Gaps = 2/37 (5%) Query: 44 VTVIGSGPGGYVAAIKAAQL--GFKTVCIEKNETLGG 78 V V+G G G A+ ++ K V +E +E LGG Sbjct: 11 VVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGG 47 >3LOV-A nrPDB Length = 475 Score = 33.4 bits (75), Expect = 0.27, Method: Composition-based stats. Identities = 11/37 (29%), Positives = 16/37 (43%), Gaps = 2/37 (5%) Query: 44 VTVIGSGPGGYVAAIKAAQL--GFKTVCIEKNETLGG 78 + ++G G G AA A + +E E LGG Sbjct: 7 LVIVGGGITGLAAAYYAERAFPDLNITLLEAGERLGG 43 >2XVH-A nrPDB Length = 464 Score = 33.4 bits (75), Expect = 0.28, Method: Composition-based stats. Identities = 42/235 (17%), Positives = 73/235 (31%), Gaps = 57/235 (24%) Query: 44 VTVIGSGPGGYV---AAIKAAQLGFKT---VCIEKNETLGG-------TCL--NVGCI-- 86 + ++G+GP G A A + G + VC EK GG T L N + Sbjct: 5 IAILGAGPSGMAQLRAFQSAQEKGAEIPELVCFEKQADWGGQWNYTWRTGLDENGEPVHS 64 Query: 87 ----------PSKALLNNSHYYHMAHGKDFASRG-----IEMSEVRLNLDKMMEQKSTAV 131 P + L + + GK AS + + R+ + Sbjct: 65 SMYRYLWSNGPKECLEFADYTFDEHFGKPIASYPPREVLWDYIKGRVE----KAGVRKYI 120 Query: 132 KALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVI---DTKNILIATG---- 184 + T F + T T D T I + ++ TG Sbjct: 121 RFNTAVRHVEFNE-------------DSQTFTVTVQDHTTDTIYSEEFDYVVCCTGHFST 167 Query: 185 SEVTPFPGITIDEDTIVSSTGALS-LKKVPEKMVVIGAGVIGVELGSVWQRLGAD 238 V F G I+ + L+ + ++++G+ ++GS + GA Sbjct: 168 PYVPEFEGFEKFGGRILHAHDFRDALEFKDKTVLLVGSSYSAEDIGSQCYKYGAK 222 Score = 32.6 bits (73), Expect = 0.46, Method: Composition-based stats. Identities = 14/76 (18%), Positives = 28/76 (36%), Gaps = 6/76 (7%) Query: 259 KNFQRILQKQGFK--FKLNTKVTGATKKSDGKI-DVSIEAASGGKAEVITCDVLLVCIGR 315 + ++K G + + NT V D + V+++ + D ++ C G Sbjct: 105 DYIKGRVEKAGVRKYIRFNTAVRHVEFNEDSQTFTVTVQDHTTDTIYSEEFDYVVCCTGH 164 Query: 316 --RPFTKNL-GLEELG 328 P+ G E+ G Sbjct: 165 FSTPYVPEFEGFEKFG 180 >1FOH-A nrPDB Length = 664 Score = 33.0 bits (74), Expect = 0.29, Method: Composition-based stats. Identities = 12/38 (31%), Positives = 19/38 (50%), Gaps = 5/38 (13%) Query: 43 DVTVIGSGPGGYVAAIKAAQL-----GFKTVCIEKNET 75 DV ++G+GP G +AA ++ K I+K T Sbjct: 9 DVLIVGAGPAGLMAARVLSEYVRQKPDLKVRIIDKRST 46 >5EZ7-A nrPDB Length = 392 Score = 33.0 bits (74), Expect = 0.29, Method: Composition-based stats. Identities = 12/41 (29%), Positives = 22/41 (53%), Gaps = 1/41 (2%) Query: 38 QPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 Q + D+ ++G G G + + G+ TV +E + +LGG Sbjct: 4 QALSTDILIVGGGIAGLWLNARLRRAGYATVLVE-SASLGG 43 Score = 28.0 bits (61), Expect = 9.7, Method: Composition-based stats. Identities = 8/37 (21%), Positives = 18/37 (48%) Query: 209 LKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFL 245 + + ++++G G+ G+ L + +R G VE Sbjct: 3 PQALSTDILIVGGGIAGLWLNARLRRAGYATVLVESA 39 >3JSK-A nrPDB Length = 344 Score = 33.0 bits (74), Expect = 0.31, Method: Composition-based stats. Identities = 10/40 (25%), Positives = 18/40 (45%), Gaps = 2/40 (5%) Query: 41 DADVTVIGSGPGGYVAAIKAAQL--GFKTVCIEKNETLGG 78 + D+ ++G+G G AA + L + +E GG Sbjct: 79 ETDIVIVGAGSCGLSAAYVLSTLRPDLRITIVEAGVAPGG 118 >3CP2-A nrPDB Length = 649 Score = 33.0 bits (74), Expect = 0.31, Method: Composition-based stats. Identities = 15/41 (36%), Positives = 24/41 (58%) Query: 30 VPLRTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCI 70 VP ++ P DV +IG G G AA+ AA++G +T+ + Sbjct: 15 VPRGSHMFYPDPFDVIIIGGGHAGTEAAMAAARMGQQTLLL 55 >4Z44-A nrPDB Length = 554 Score = 33.0 bits (74), Expect = 0.31, Method: Composition-based stats. Identities = 13/45 (28%), Positives = 25/45 (55%), Gaps = 4/45 (8%) Query: 30 VPLRTYADQPIDADVTVIGSGPGGYVAA---IKAAQLGFKTVCIE 71 VP ++ ++PI ++ ++G G G++AA ++A Q IE Sbjct: 11 VPRGSHMNKPIK-NIVIVGGGTAGWMAASYLVRALQQQANITLIE 54 >3L1R-A nrPDB Length = 478 Score = 33.0 bits (74), Expect = 0.34, Method: Composition-based stats. Identities = 12/36 (33%), Positives = 20/36 (55%), Gaps = 1/36 (2%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCI-EKNETLGG 78 V V+G+G G AA + ++ G + I E + +GG Sbjct: 7 VIVVGAGMSGISAAKRLSEAGITDLLILEATDHIGG 42 >4IA5-A nrPDB Length = 591 Score = 32.6 bits (73), Expect = 0.37, Method: Composition-based stats. Identities = 16/86 (18%), Positives = 30/86 (34%), Gaps = 10/86 (11%) Query: 239 VTAVEFLGHVGGVGIDM-----EISKNFQRILQKQGFKFKLNTKV--TGATKKSDGKIDV 291 + ++ L + + + K L+ G +F+ + V + D KI Sbjct: 205 IHHIDGLPDFTALKFNKYNQYESMVKPLLAYLKDHGVQFEYDCHVKNVEVDHEGDSKIAK 264 Query: 292 SIEAASGGKAEVIT---CDVLLVCIG 314 I GK + I D++ V G Sbjct: 265 KIVMTQNGKDKEIDLTHNDIVFVTNG 290 >5TUM-A nrPDB Length = 410 Score = 32.6 bits (73), Expect = 0.46, Method: Composition-based stats. Identities = 18/104 (17%), Positives = 38/104 (36%), Gaps = 9/104 (8%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGF---- 270 K++VIGAGV G + +R G +E + G +++ I ++ G Sbjct: 27 KILVIGAGVAGPAVCYWLRRFGFSPVLIEKYASIRKGGQALDVRGIATHIAREMGIYDQI 86 Query: 271 -----KFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVL 309 + + V + K + + E++ D++ Sbjct: 87 CEMRTRIERGRFVDSSGKVLHEEQGEKFGFRQDDEVEILRGDLV 130 Score = 31.8 bits (71), Expect = 0.74, Method: Composition-based stats. Identities = 15/42 (35%), Positives = 21/42 (50%), Gaps = 2/42 (4%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETL--GGTCLNV 83 + VIG+G G + GF V IEK ++ GG L+V Sbjct: 28 ILVIGAGVAGPAVCYWLRRFGFSPVLIEKYASIRKGGQALDV 69 >6FZI-A nrPDB Length = 332 Score = 32.2 bits (72), Expect = 0.48, Method: Composition-based stats. Identities = 20/107 (18%), Positives = 37/107 (34%), Gaps = 9/107 (8%) Query: 117 RLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVT--ATKADGGTQVI 174 RL L M++ V A+ + + + G+ G+ +V A +G + Sbjct: 14 RLALRLMIDNPEFEVVAINDLTDAKTLAHLFKYDSAQGRFNGEIEVKEGAFVVNGKEIKV 73 Query: 175 DTKNILIATGSEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVVIGA 221 K S P + D ++ TG + K+ + GA Sbjct: 74 TAK-------SNPAELPWGELGVDVVLECTGFFASKEKASAHLTAGA 113 >6DLL-A nrPDB Length = 398 Score = 32.2 bits (72), Expect = 0.50, Method: Composition-based stats. Identities = 31/159 (19%), Positives = 53/159 (33%), Gaps = 23/159 (14%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET---LG----GTCLNVGCIPSKALL 92 + V +IG+GP G + + G + +E+ LG G L G + LL Sbjct: 4 MKTQVAIIGAGPSGLLLGQLLHKAGIDNIIVERQTAEYVLGRIRAGV-LEQGTV---DLL 59 Query: 93 NNSHYYHMAHGKDFASRGIE----MSEVRLNLDKMMEQKSTAVKALTGGIAHLF---KQN 145 + + G+E RL+L + K+ V T L + + Sbjct: 60 REAGVAERMDREGLVHEGVELLVGGRRQRLDLKALTGGKTVMVYGQTEVTRDLMQAREAS 119 Query: 146 KVVHVNGYG-----KITGKNQVTATKADGGTQVIDTKNI 179 + ++ G+ + DG Q ID I Sbjct: 120 GAPIIYSAANVQPHELKGEKPYLTFEKDGRVQRIDCDYI 158 Score = 31.8 bits (71), Expect = 0.70, Method: Composition-based stats. Identities = 13/55 (23%), Positives = 22/55 (40%), Gaps = 6/55 (10%) Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEF------LGHVGGVGIDMEISKNFQRI 264 + +IGAG G+ LG + + G D VE LG + ++ + Sbjct: 8 VAIIGAGPSGLLLGQLLHKAGIDNIIVERQTAEYVLGRIRAGVLEQGTVDLLREA 62 >5TUK-A nrPDB Length = 408 Score = 32.2 bits (72), Expect = 0.55, Method: Composition-based stats. Identities = 21/116 (18%), Positives = 41/116 (35%), Gaps = 12/116 (10%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGF---- 270 K++VIGAG+ G + +R G VE ++ G ++I + + G Sbjct: 27 KILVIGAGIAGPAVCYWLRRFGFSPILVERCANLRKGGHAVDIRGVAIDLAKSMGIYKKI 86 Query: 271 -----KFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVL---LVCIGRRPF 318 + +L V + G E++ D++ + +G P Sbjct: 87 CNMRTQVELGRYVDAEGNILHEEKGERFGFREGDDIEILRGDLVQILIDAMGDVPC 142 Score = 30.3 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 13/47 (27%), Positives = 22/47 (46%), Gaps = 2/47 (4%) Query: 39 PIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETL--GGTCLNV 83 PI + VIG+G G + GF + +E+ L GG +++ Sbjct: 23 PIINKILVIGAGIAGPAVCYWLRRFGFSPILVERCANLRKGGHAVDI 69 >4U2L-A nrPDB Length = 510 Score = 32.2 bits (72), Expect = 0.56, Method: Composition-based stats. Identities = 10/30 (33%), Positives = 19/30 (63%) Query: 45 TVIGSGPGGYVAAIKAAQLGFKTVCIEKNE 74 VIG+G G V+A++ + G +T+ +E + Sbjct: 9 VVIGTGYGAAVSALRLGEAGVQTLMLEMGQ 38 >2GAG-B nrPDB Length = 405 Score = 32.2 bits (72), Expect = 0.58, Method: Composition-based stats. Identities = 10/39 (25%), Positives = 14/39 (35%), Gaps = 2/39 (5%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGF--KTVCIEKNETLGG 78 D ++G G G A A+ +EK GG Sbjct: 22 YDAIIVGGGGHGLATAYFLAKNHGITNVAVLEKGWLAGG 60 >5H82-A nrPDB Length = 389 Score = 32.2 bits (72), Expect = 0.62, Method: Composition-based stats. Identities = 37/160 (23%), Positives = 56/160 (35%), Gaps = 23/160 (14%) Query: 146 KVVHVNGYGKITGKNQVTATKADGGTQVI--DTKNILIA----TGSEVTPFP---GITID 196 KV++ +G N V + G I NI++A P G+ I Sbjct: 135 KVIYTDGTAFSDENNTVYGDVSGDGEDRIYGGYSNIMVANEYVVFRWPENLPLAAGVPIL 194 Query: 197 EDTIV--SSTGALSLKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGID 254 IV S L K + V+G G IG + GA+VT + Sbjct: 195 CGGIVPYSPMRHFGLDKPGLSIGVVGFGRIGKLAVKFAKAFGANVTVIST---------- 244 Query: 255 MEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKIDVSIE 294 ISK Q ++K G L +K K ++ +D + Sbjct: 245 -SISKK-QEAIEKYGVDRFLISKEPEEMKAAESTLDGIFD 282 >5TUL-A nrPDB Length = 406 Score = 31.8 bits (71), Expect = 0.63, Method: Composition-based stats. Identities = 16/101 (15%), Positives = 35/101 (34%), Gaps = 6/101 (5%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFK-- 271 +K++VIGA + G L G T VE G +++ + ++ G Sbjct: 26 KKILVIGASIAGPALCYWLNHYGFQPTLVEKNQSTRKGGYAIDLRGIAVDVAKQMGIYDS 85 Query: 272 ---FKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVL 309 + + + + G + GG + +++ Sbjct: 86 VCAMRTSLQCVRYV-DAAGNLLFEEHGEKGGFRQGDEVEIV 125 >4XRR-A nrPDB Length = 456 Score = 31.8 bits (71), Expect = 0.63, Method: Composition-based stats. Identities = 13/31 (41%), Positives = 18/31 (58%) Query: 213 PEKMVVIGAGVIGVELGSVWQRLGADVTAVE 243 P K+V+ GAG +G L GA+V AV+ Sbjct: 15 PLKVVIAGAGYVGTCLAVTLAGRGAEVVAVD 45 >2Y0D-A nrPDB Length = 478 Score = 31.8 bits (71), Expect = 0.64, Method: Composition-based stats. Identities = 47/285 (16%), Positives = 93/285 (32%), Gaps = 46/285 (16%) Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 + +IG+G +G+ G+ +G DV +++ + IL G Sbjct: 11 LTIIGSGKVGLVTGACLADIGHDV-------------FCLDVDQAKIDILNNGGVPIH-- 55 Query: 276 TKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGRRPFTKN------LGLEELGI 329 + + + + ++ +A V DV + +G P + I Sbjct: 56 -EPGLKEVIARNRSAGRLRFSTDIEAAVAHGDVQFIAVGTPPDEDGSADLQYVLAAARNI 114 Query: 330 ELDPRGR-IPVNTRFQTKIPNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNC 388 G + V+ ++ +P +G A + A AE+ + M + ++ Sbjct: 115 GRYMTGFKVIVD---KSTVP----VG--TAERVRAAVAEELAKRGGDQMFSVVSNPEFLK 165 Query: 389 VPSVI--YTHPEVAWVGKSEEQLKEEGIEY-KVGKFPFAANSRA--KTNADTDGMVKILG 443 + + +T P+ +G ++ E E K PF N + + K Sbjct: 166 EGAAVDDFTRPDRIVIGCDDDVPGERARELMKKLYAPFNRNHERTLYMDVRSAEFTKYAA 225 Query: 444 QKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHP 488 +L M A LA +GA E + R + P Sbjct: 226 NA---------MLATRISFMNELANLADRFGADIEAVRRGIGSDP 261 >2GV8-A nrPDB Length = 447 Score = 31.8 bits (71), Expect = 0.64, Method: Composition-based stats. Identities = 11/38 (28%), Positives = 19/38 (50%), Gaps = 2/38 (5%) Query: 44 VTVIGSGPGGYVA--AIKAAQLGFKTVCIEKNETLGGT 79 + +IG+GP G V A+ A + + E+ + GG Sbjct: 9 IAIIGAGPSGLVTAKALLAEKAFDQVTLFERRGSPGGV 46 >1X14-A nrPDB Length = 401 Score = 31.8 bits (71), Expect = 0.64, Method: Composition-based stats. Identities = 15/37 (40%), Positives = 19/37 (51%) Query: 212 VPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHV 248 P K++VIGAGV G+ LGA V A + V Sbjct: 171 PPAKVMVIGAGVAGLAAIGAANSLGAIVRAFDTRPEV 207 >3HN2-A nrPDB Length = 312 Score = 31.8 bits (71), Expect = 0.67, Method: Composition-based stats. Identities = 10/32 (31%), Positives = 19/32 (59%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLG 246 ++ ++GAG +G+ G++ QR G DV + Sbjct: 4 RIAIVGAGALGLYYGALLQRSGEDVHFLLRRD 35 >1E3J-A nrPDB Length = 352 Score = 31.8 bits (71), Expect = 0.68, Method: Composition-based stats. Identities = 12/34 (35%), Positives = 17/34 (50%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET 75 V VIG+GP G V+ + A G VC ++ Sbjct: 170 TTVLVIGAGPIGLVSVLAAKAYGAFVVCTARSPR 203 >3KKJ-A nrPDB Length = 336 Score = 31.8 bits (71), Expect = 0.68, Method: Composition-based stats. Identities = 10/35 (28%), Positives = 16/35 (45%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 + +IG+G G AA G + +K+ GG Sbjct: 5 IAIIGTGIAGLSAAQALTAAGHQVHLFDKSRGSGG 39 Score = 29.1 bits (64), Expect = 4.6, Method: Composition-based stats. Identities = 9/66 (13%), Positives = 18/66 (27%), Gaps = 4/66 (6%) Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLG----HVGGVGIDMEISKNFQRILQKQGFK 271 + +IG G+ G+ G V + + D + + + Sbjct: 5 IAIIGTGIAGLSAAQALTAAGHQVHLFDKSRGSGGRMSSKRSDAGALDMGAQYFTARDRR 64 Query: 272 FKLNTK 277 F K Sbjct: 65 FATAVK 70 >3OJO-A nrPDB Length = 431 Score = 31.8 bits (71), Expect = 0.81, Method: Composition-based stats. Identities = 19/101 (18%), Positives = 39/101 (38%), Gaps = 7/101 (6%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKN---FQRILQKQGF 270 K+ V+G G IG+ ++ + G DV V+ + +IS Q + ++ Sbjct: 12 SKLTVVGLGYIGLPTSIMFAKHGVDVLGVDINQQTIDKLQNGQISIEEPGLQEVYEE--- 68 Query: 271 KFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLV 311 + K+ +T + + + +CD+ LV Sbjct: 69 -VLSSGKLKVSTTPEASDVFIIAVPTPNNDDQYRSCDISLV 108 >4ZCC-A nrPDB Length = 336 Score = 31.4 bits (70), Expect = 0.86, Method: Composition-based stats. Identities = 10/35 (28%), Positives = 16/35 (45%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGG 78 + +IG+G G AA G + +K+ GG Sbjct: 5 IAIIGTGIAGLSAAQALTSAGHQVHLFDKSRGSGG 39 Score = 28.0 bits (61), Expect = 9.1, Method: Composition-based stats. Identities = 8/36 (22%), Positives = 13/36 (36%) Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGV 251 + +IG G+ G+ G V + GG Sbjct: 5 IAIIGTGIAGLSAAQALTSAGHQVHLFDKSRGSGGR 40 >5XMJ-A nrPDB Length = 627 Score = 31.4 bits (70), Expect = 0.98, Method: Composition-based stats. Identities = 11/33 (33%), Positives = 16/33 (48%) Query: 38 QPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCI 70 Q DV IG G A++A+ G KT+ + Sbjct: 2 QIYHTDVLCIGGALAGERVAVEASMAGLKTIML 34 >5X68-A nrPDB Length = 391 Score = 31.1 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 7/42 (16%), Positives = 13/42 (30%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDM 255 +K+ VIG G++G + + E Sbjct: 15 KKVAVIGGGLVGSLQACFLAKRNFQIDVYEAREDTRVATFTR 56 >2YFH-A nrPDB Length = 448 Score = 31.1 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 30/155 (19%), Positives = 52/155 (33%), Gaps = 9/155 (5%) Query: 136 GGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEVTPFPGITI 195 G +A K+ +V++ G + + A +D + LIA G + G + Sbjct: 290 GRVADYAKEFGLVYLEGQQPWSLPVDIALPCATQNELDVDAAHQLIANGVKAVA-EGANM 348 Query: 196 DEDTIVSSTGALS---LKKVPEKMVVIGA-GVIGVELGSVWQRLGADVTAVEFLGHVGGV 251 T + +T + P K G G+E+ RLG V+ H Sbjct: 349 P--TTIEATELFQQAGVLFAPGKAANAGGVATSGLEMAQNAARLGWKAEKVDARLHHIMT 406 Query: 252 GIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSD 286 I + +R G+ + G K +D Sbjct: 407 DIHDGSAAAAERY--GLGYNLVAGANIVGFQKIAD 439 >5ZYN-B nrPDB Length = 471 Score = 31.1 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 11/36 (30%), Positives = 19/36 (52%), Gaps = 1/36 (2%) Query: 44 VTVIGSGPGGYVAAIKA-AQLGFKTVCIEKNETLGG 78 V VIGSG G + + ++ V ++K ++GG Sbjct: 7 VVVIGSGLAGLTTSNRLISKYRIPVVLLDKAASIGG 42 >3G05-A nrPDB Length = 576 Score = 31.1 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 13/32 (40%), Positives = 20/32 (62%) Query: 39 PIDADVTVIGSGPGGYVAAIKAAQLGFKTVCI 70 P DV +IG G G AA+ AA++G +T+ + Sbjct: 30 PDPFDVIIIGGGHAGTEAAMAAARMGQQTLLL 61 >4A7P-A nrPDB Length = 446 Score = 31.1 bits (69), Expect = 1.2, Method: Composition-based stats. Identities = 17/100 (17%), Positives = 40/100 (40%), Gaps = 16/100 (16%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL 274 ++ +IG G +G+ G+ + G +V V D + ++ + + Q ++ Sbjct: 10 RIAMIGTGYVGLVSGACFSDFGHEVVCV-----------DKD-ARKIELLHQNVMPIYEP 57 Query: 275 NTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIG 314 A+ G++ + + A G K D + + +G Sbjct: 58 GLDALVASNVKAGRLSFTTDLAEGVK----DADAVFIAVG 93 >2BS2-A nrPDB Length = 660 Score = 31.1 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 11/28 (39%), Positives = 14/28 (50%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCI 70 D VIG G G AA+ Q G T+ + Sbjct: 7 DSLVIGGGLAGLRAAVATQQKGLSTIVL 34 >3IHM-A nrPDB Length = 430 Score = 30.7 bits (68), Expect = 1.4, Method: Composition-based stats. Identities = 9/28 (32%), Positives = 17/28 (60%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTA 241 +++ ++GAG G+ LG ++ DVT Sbjct: 23 KRIGIVGAGTAGLHLGLFLRQHDVDVTV 50 >3RP7-A nrPDB Length = 407 Score = 30.7 bits (68), Expect = 1.4, Method: Composition-based stats. Identities = 12/38 (31%), Positives = 19/38 (50%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVG 252 K +VIGAG+ G+ ++ G D E + + VG Sbjct: 25 KAIVIGAGIGGLSAAVALKQSGIDCDVYEAVKEIKPVG 62 Score = 30.7 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 11/32 (34%), Positives = 15/32 (46%) Query: 45 TVIGSGPGGYVAAIKAAQLGFKTVCIEKNETL 76 VIG+G GG AA+ Q G E + + Sbjct: 27 IVIGAGIGGLSAAVALKQSGIDCDVYEAVKEI 58 >3GG2-A nrPDB Length = 450 Score = 30.7 bits (68), Expect = 1.4, Method: Composition-based stats. Identities = 21/117 (17%), Positives = 47/117 (40%), Gaps = 26/117 (22%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGH-----------VGGVGIDMEISKNFQR 263 + V+G G +G+ + + LGA+V ++ + + G++ I++N + Sbjct: 4 DIAVVGIGYVGLVSATCFAELGANVRCIDTDRNKIEQLNSGTIPIYEPGLEKMIARNVKA 63 Query: 264 ILQKQGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDV--LLVC---IGR 315 + + T++ A ++D + A E + D+ +L IGR Sbjct: 64 G------RLRFGTEIEQAVPEAD----IIFIAVGTPAGEDGSADMSYVLDAARSIGR 110 Score = 28.4 bits (62), Expect = 8.8, Method: Composition-based stats. Identities = 12/29 (41%), Positives = 17/29 (58%) Query: 43 DVTVIGSGPGGYVAAIKAAQLGFKTVCIE 71 D+ V+G G G V+A A+LG CI+ Sbjct: 4 DIAVVGIGYVGLVSATCFAELGANVRCID 32 >5TUF-A nrPDB Length = 409 Score = 30.7 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 19/104 (18%), Positives = 36/104 (34%), Gaps = 9/104 (8%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGF---- 270 K++VIG GV G + +R G +E V G ++I I ++ G Sbjct: 27 KILVIGVGVAGPAVAYWLKRFGFSPVLIEKSAAVRKGGQALDIRGIATHIAKEMGIYDQI 86 Query: 271 -----KFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVL 309 + K V + + + E++ D++ Sbjct: 87 CNMRTQIKCGRYVDVKGNVLHEEQGETFGFRQDDEVEILRGDLV 130 Score = 29.5 bits (65), Expect = 3.3, Method: Composition-based stats. Identities = 14/37 (37%), Positives = 18/37 (48%), Gaps = 2/37 (5%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETL--GG 78 + VIG G G A + GF V IEK+ + GG Sbjct: 28 ILVIGVGVAGPAVAYWLKRFGFSPVLIEKSAAVRKGG 64 >4K22-A nrPDB Length = 365 Score = 30.7 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 7/31 (22%), Positives = 15/31 (48%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFL 245 + ++G G++G+ + Q G V +E Sbjct: 5 DVAIVGGGMVGLAVACGLQGSGLRVAVLEQR 35 >5W1A-A nrPDB Length = 810 Score = 30.7 bits (68), Expect = 1.6, Method: Composition-based stats. Identities = 24/116 (20%), Positives = 41/116 (35%), Gaps = 18/116 (15%) Query: 348 PNIYAIGDVVAGPMLAHKAEDEGIICVEGMAGGAVHIDYNCVPSVIYTHPEVAWVG---K 404 P+I+AI D ML + ++ ++ G + A VG K Sbjct: 153 PHIFAISDGAYVDMLTNH-VNQSMLITGESGAGKTENTKKVIAYF-------ATVGASKK 204 Query: 405 SEEQLKEEG---IEYKVGKFPFAANSRAKT--NADTDGMVKILGQ--KSTDRVLGA 453 ++E K +G + A AKT N ++ K + T ++ GA Sbjct: 205 TDEAAKSKGSLEDQVVQTNPVLEAFGNAKTVRNDNSSRFGKFIRIHFGPTGKLAGA 260 >4R16-A nrPDB Length = 418 Score = 30.7 bits (68), Expect = 1.8, Method: Composition-based stats. Identities = 13/58 (22%), Positives = 24/58 (41%), Gaps = 7/58 (12%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGV-------GIDMEISKNFQRIL 265 ++ V+G G IG+ ++ G DV + V I+ EI + + +L Sbjct: 2 RIAVLGLGYIGLPTAIMFASSGYDVVGYDIRSEVIKKINSGVAHIIEPEIDRRLKEVL 59 >5OC1-A nrPDB Length = 565 Score = 30.7 bits (68), Expect = 1.8, Method: Composition-based stats. Identities = 32/173 (18%), Positives = 53/173 (30%), Gaps = 23/173 (13%) Query: 41 DADVTVIGSGPGG-YVAAIKAAQLGFKTVCIEKNET----LGGTCLNV--GCIPSKALLN 93 D D V+G+G G VAA + +E + LG + G +P+ Sbjct: 1 DFDYVVVGAGNAGNVVAARLTEDPDVSVLVLEAGVSDENVLGAEAPLLAPGLVPNSIFDW 60 Query: 94 NSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKST--AVKALTGGIAHLFKQNKVVHVN 151 N A G + +M+ S+ + + G + V Sbjct: 61 NYTTTAQA--------GYNGRSIAYPRGRMLGGSSSVHYMVMMRGSTEDFDRYAAVTGDE 112 Query: 152 GYG-----KITGKNQVTATKADGGTQVIDTKNILIAT-GSEVTPFPGITIDED 198 G+ + KN++ AD + + T GS PG D Sbjct: 113 GWNWDNIQQFVRKNEMVVPPADNHNTSGEFIPAVHGTNGSVSISLPGFPTPLD 165 >4KUG-A nrPDB Length = 290 Score = 30.3 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 13/57 (22%), Positives = 27/57 (47%), Gaps = 1/57 (1%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGF 270 +K+ V+GAG +G + + G +V + GI I+K+ +++ K+ Sbjct: 2 KKVFVLGAGTMGAGIVQAFAAKGCEVIVRDIKEEFVDRGI-ATITKSLSKLVAKEKI 57 >1XJ5-A nrPDB Length = 334 Score = 30.3 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 22/156 (14%), Positives = 48/156 (30%), Gaps = 26/156 (16%) Query: 159 KNQVTATKADGGTQVIDTKNILI--ATGSEVTPFPGITIDEDT-------IVSSTGALSL 209 + + K + I+ AT +V G+ + +++ S+ Sbjct: 59 AHSLKVEKVLFQGKSDYQDVIVFQSATYGKVLVLDGVIQLTERDECAYQEMITHLPLCSI 118 Query: 210 KKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRIL---- 265 P+K++VIG G G V + + + + ID + ++ Sbjct: 119 PN-PKKVLVIGGGD-----GGVLREVARHASI----EQIDMCEIDKMVVDVSKQFFPDVA 168 Query: 266 ---QKQGFKFKLNTKVTGATKKSDGKIDVSIEAASG 298 + + V ++G D I +S Sbjct: 169 IGYEDPRVNLVIGDGVAFLKNAAEGSYDAVIVDSSD 204 >2IVE-A nrPDB Length = 478 Score = 30.3 bits (67), Expect = 2.1, Method: Composition-based stats. Identities = 13/74 (17%), Positives = 27/74 (36%) Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 + V+G G+ G+ + + G D +E +GG ++ + Sbjct: 19 VAVVGGGISGLAVAHHLRSRGTDAVLLESSARLGGAVGTHALAGYLVEQGPNSFLDREPA 78 Query: 276 TKVTGATKKSDGKI 289 T+ A +G+I Sbjct: 79 TRALAAALNLEGRI 92 Score = 29.1 bits (64), Expect = 4.5, Method: Composition-based stats. Identities = 12/36 (33%), Positives = 15/36 (41%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGT 79 V V+G G G A G V +E + LGG Sbjct: 19 VAVVGGGISGLAVAHHLRSRGTDAVLLESSARLGGA 54 >3K96-A nrPDB Length = 356 Score = 30.3 bits (67), Expect = 2.3, Method: Composition-based stats. Identities = 18/127 (14%), Positives = 45/127 (35%), Gaps = 13/127 (10%) Query: 33 RTYADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVC-------IEKNETLGGTCLNVGC 85 ++ A +P + ++G+G G A+ A+ G K +++ + G +N Sbjct: 21 QSNAMEPFKHPIAILGAGSWGTALALVLARKGQKVRLWSYESDHVDEMQAEG---VNNRY 77 Query: 86 IPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLDKMMEQKSTAVK---ALTGGIAHLF 142 +P+ Y I + +++ + + + G L Sbjct: 78 LPNYPFPETLKAYCDLKASLEGVTDILIVVPSFAFHEVITRMKPLIDAKTRIAWGTKGLA 137 Query: 143 KQNKVVH 149 K ++++H Sbjct: 138 KGSRLLH 144 >4FWE-A nrPDB Length = 796 Score = 30.3 bits (67), Expect = 2.3, Method: Composition-based stats. Identities = 7/23 (30%), Positives = 9/23 (39%) Query: 232 WQRLGADVTAVEFLGHVGGVGID 254 G VT +E +GG D Sbjct: 375 LHNFGIKVTVLEAKDRIGGRVWD 397 >4Z25-A nrPDB Length = 652 Score = 29.9 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 9/34 (26%), Positives = 17/34 (50%), Gaps = 1/34 (2%) Query: 43 DVTVIGSGPGGYVAAIKAAQL-GFKTVCIEKNET 75 D+ +IG+G G + A A+ K + +E + Sbjct: 8 DIVIIGAGAAGSLLAHYLARFSNMKIILLEAGHS 41 >4B4O-A nrPDB Length = 298 Score = 29.9 bits (66), Expect = 2.4, Method: Composition-based stats. Identities = 12/48 (25%), Positives = 19/48 (39%), Gaps = 1/48 (2%) Query: 215 KMVVIGA-GVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNF 261 +++V G G IG L + G +VT V G + D + Sbjct: 2 RVLVGGGTGFIGTALTQLLNARGHEVTLVSRKPGPGRITWDELAASGL 49 >3OML-A nrPDB Length = 613 Score = 29.9 bits (66), Expect = 2.6, Method: Composition-based stats. Identities = 18/100 (18%), Positives = 37/100 (37%), Gaps = 7/100 (7%) Query: 214 EKMVVI-GAGV-IGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFK 271 ++ V+ GAG +G E ++ GA V + G G G + ++K G Sbjct: 19 GRVAVVTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIRKAG-- 76 Query: 272 FKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLV 311 V DG + + G+ +++ + ++ Sbjct: 77 ---GEAVADYNSVIDGAKVIETAIKAFGRVDILVNNAGIL 113 >3K6J-A nrPDB Length = 460 Score = 29.9 bits (66), Expect = 2.7, Method: Composition-based stats. Identities = 17/59 (28%), Positives = 24/59 (40%), Gaps = 6/59 (10%) Query: 21 SHGLQGLSAVPLRTYADQPID--ADV---TVIGSGPGGYVAAIKAAQLGFKTVCIEKNE 74 +H L G ++P D DV +IG G G AI G +T + +NE Sbjct: 30 AHSLAGQWSLP-NDRGDHTNSEAYDVNSVAIIGGGTMGKAMAICFGLAGIETFLVVRNE 87 >2CZG-A nrPDB Length = 433 Score = 29.9 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 49/270 (18%), Positives = 90/270 (33%), Gaps = 39/270 (14%) Query: 44 VTVIGSGPGGYVAAIKAAQLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHG 103 + ++GSG G AI+A +LG + V +++ P+ + + S+ +M Sbjct: 22 ILLLGSGELGKEIAIEAQRLGVEVVAVDRYAN----------APAMQVAHRSYVGNMM-D 70 Query: 104 KDFASRGIEMSEVRLNLDKMMEQKSTAVKALTGGIAHLFKQNKVVHV-NGYGKITGKNQV 162 KDF +E + + + ++A+ F+++ V N ++ Sbjct: 71 KDFLWSVVEREKPDAIIPE--------IEAINLDALFEFEKDGYFVVPNARATWIAMHRE 122 Query: 163 TATKADGGTQVIDTKNILIATG----SEVTPFPGITIDEDTIVSSTGALSLKKVPEKMVV 218 + + T + AT E G I+SS+G V Sbjct: 123 RLRETLVKEAKVPTSRYMYATTLDELYEACEKIGYPCHTKAIMSSSG-------KGSYFV 175 Query: 219 IGAGVI--GVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNT 276 G I E R A+ VE H+ D+E+++ R + G Sbjct: 176 KGPEDIPKAWEEAKTKARGSAEKIIVE--EHI---DFDVEVTELAVRHFDENGEIVTTFP 230 Query: 277 KVTGATKKSDGKIDVSIEAASGGKAEVITC 306 K G + DG S + A + Sbjct: 231 KPVGH-YQIDGDYHASWQPAEISEKAEREV 259 >4IIN-A nrPDB Length = 271 Score = 29.9 bits (66), Expect = 2.8, Method: Composition-based stats. Identities = 11/65 (16%), Positives = 29/65 (44%), Gaps = 9/65 (13%) Query: 208 SLKKVPEKMVVIGAGV-IGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQ 266 +++ + +++ GA IG E+ +G V + + E++ + L+ Sbjct: 24 AMQFTGKNVLITGASKGIGAEIAKTLASMGLKV-------WINYRS-NAEVADALKNELE 75 Query: 267 KQGFK 271 ++G+K Sbjct: 76 EKGYK 80 >1XFD-A nrPDB Length = 723 Score = 29.9 bits (66), Expect = 2.9, Method: Composition-based stats. Identities = 17/62 (27%), Positives = 23/62 (37%), Gaps = 5/62 (8%) Query: 439 VKILGQKSTDRVLGAHILGPGAGEMVNEAALALEYGASCEDIARVCHAHPTLSEAFREAN 498 K+ ++R LG H L A EM +A A E + HPT E + Sbjct: 619 FKLYASAFSERYLGLHGLDNRAYEMTK---VAHRVSALEEQ--QFLIIHPTADEKIHFQH 673 Query: 499 LA 500 A Sbjct: 674 TA 675 >4PJ1-A nrPDB Length = 558 Score = 29.9 bits (66), Expect = 3.0, Method: Composition-based stats. Identities = 16/72 (22%), Positives = 26/72 (36%), Gaps = 8/72 (11%) Query: 62 QLGFKTVCIEKNETLGGTCLNVGCIPSKALLNNSHYYHMAHGKDFASRGIEMSEVRLNLD 121 L +E+ LGG C + CIP + + GIE+ + L + Sbjct: 426 ALNATRAAVEEGIVLGGGCALLRCIP--------ALDSLTPANEDQKIGIEIIKRTLKIP 477 Query: 122 KMMEQKSTAVKA 133 M K+ V+ Sbjct: 478 AMTIAKNAGVEG 489 >4MIF-A nrPDB Length = 620 Score = 29.9 bits (66), Expect = 3.0, Method: Composition-based stats. Identities = 12/37 (32%), Positives = 16/37 (43%), Gaps = 2/37 (5%) Query: 35 YADQPIDADVTVIGSGPGGYVAAIKAAQLGFKTVCIE 71 AD+P DV + GSGP G A + +E Sbjct: 9 RADEP--YDVFIAGSGPIGATFAKLCVDANLRVCMVE 43 >4X4J-A nrPDB Length = 507 Score = 29.5 bits (65), Expect = 3.1, Method: Composition-based stats. Identities = 13/65 (20%), Positives = 24/65 (36%) Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLN 275 +V+ GAG G+ L + G V +E L G + + + ++G + Sbjct: 25 VVIAGAGPAGLMLAGELRLAGIGVVVLERLPARTGESRGLGFTARTMEVFDQRGLLRRFG 84 Query: 276 TKVTG 280 T Sbjct: 85 EVQTS 89 Score = 29.1 bits (64), Expect = 4.5, Method: Composition-based stats. Identities = 11/36 (30%), Positives = 18/36 (50%) Query: 40 IDADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNET 75 +DA V + G+GP G + A + G V +E+ Sbjct: 21 MDAPVVIAGAGPAGLMLAGELRLAGIGVVVLERLPA 56 >2EEZ-A nrPDB Length = 369 Score = 29.5 bits (65), Expect = 3.2, Method: Composition-based stats. Identities = 10/42 (23%), Positives = 18/42 (42%) Query: 213 PEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGID 254 P +V++G G +G + +GA VT ++ D Sbjct: 166 PASVVILGGGTVGTNAAKIALGMGAQVTILDVNHKRLQYLDD 207 >1QP8-A nrPDB Length = 303 Score = 29.5 bits (65), Expect = 3.2, Method: Composition-based stats. Identities = 13/51 (25%), Positives = 20/51 (39%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRI 264 EK+ V+G G IG +G + LGA V G + + + Sbjct: 125 EKVAVLGLGEIGTRVGKILAALGAQVRGFSRTPKEGPWRFTNSLEEALREA 175 >5NCC-A nrPDB Length = 594 Score = 29.5 bits (65), Expect = 3.5, Method: Composition-based stats. Identities = 8/30 (26%), Positives = 13/30 (43%) Query: 41 DADVTVIGSGPGGYVAAIKAAQLGFKTVCI 70 D ++G G V A + + G K V + Sbjct: 23 KYDYILVGGGTAACVLANRLSADGSKRVLV 52 >4FHN-X nrPDB Length = 450 Score = 29.5 bits (65), Expect = 3.5, Method: Composition-based stats. Identities = 32/174 (18%), Positives = 60/174 (34%), Gaps = 14/174 (8%) Query: 120 LDKMMEQKSTAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNI 179 L +++E K + G +A K+ +V++ G + + A +D + Sbjct: 282 LARLIEIK----SSRDGRVADYAKEFGLVYLEGQQPWSVPVDIALPCATQNELDVDAAHQ 337 Query: 180 LIATGSEVTPFPGITIDEDTIVSSTGALS---LKKVPEKMVVIGA-GVIGVELGSVWQRL 235 LIA G + G + T + +T + P K G G+E+ RL Sbjct: 338 LIANGVKAVA-EGANMP--TTIEATELFQQAGVLFAPGKAANAGGVATSGLEMAQNAARL 394 Query: 236 GADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKLNTKVTGATKKSDGKI 289 G V+ H + I ++ Q + + G K +D + Sbjct: 395 GWKAEKVDARLHHIMLDIHHACVEHGGEGEQTNYVQ---GANIAGFVKVADAML 445 >2F1K-A nrPDB Length = 279 Score = 29.5 bits (65), Expect = 3.5, Method: Composition-based stats. Identities = 11/51 (21%), Positives = 21/51 (41%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRIL 265 K+ V+G G+IG L +R G + V ++ ++ + L Sbjct: 2 KIGVVGLGLIGASLAGDLRRRGHYLIGVSRQQSTCEKAVERQLVDEAGQDL 52 >5U4H-A nrPDB Length = 421 Score = 29.5 bits (65), Expect = 3.6, Method: Composition-based stats. Identities = 18/108 (16%), Positives = 35/108 (32%), Gaps = 15/108 (13%) Query: 408 QLKEEGIEYKVGKFPFAANSRAKTNADTDGMVKILGQKSTDRVLGAHILGPGA------- 460 + IE + G + R K + + ++ T+ +L A L G Sbjct: 134 EALGAHIEVENGYVHATVDGRLKGG---EVVFDMVTVGGTENILMAAALADGVTTIRNAA 190 Query: 461 --GEMVNEAALALEYGASCEDIA-RVCHAHPTLSEAFREANLAASFGK 505 E+ + A + ++ GA E + T E+ A + Sbjct: 191 REPEITDLAQMLIKMGAKIEGLDTDTLVV--TGVESLHGCEYAVVADR 236 >4UDQ-A nrPDB Length = 531 Score = 29.5 bits (65), Expect = 3.6, Method: Composition-based stats. Identities = 9/33 (27%), Positives = 16/33 (48%), Gaps = 1/33 (3%) Query: 42 ADVTVIGSGPGGYVAAIK-AAQLGFKTVCIEKN 73 D ++G G G V A + +A+ + + IE Sbjct: 6 FDYVIVGGGTAGSVLANRLSARPENRVLLIEAG 38 >4HA6-A nrPDB Length = 508 Score = 29.5 bits (65), Expect = 3.8, Method: Composition-based stats. Identities = 9/33 (27%), Positives = 16/33 (48%), Gaps = 1/33 (3%) Query: 43 DVTVIGSGPGG-YVAAIKAAQLGFKTVCIEKNE 74 D+ ++G G G +AA + + + IE E Sbjct: 3 DIVIVGGGSAGSLLAARLSEDPDSRVLLIEAGE 35 >3KYD-B nrPDB Length = 551 Score = 29.5 bits (65), Expect = 3.9, Method: Composition-based stats. Identities = 8/15 (53%), Positives = 12/15 (80%) Query: 214 EKMVVIGAGVIGVEL 228 +++V+GAG IG EL Sbjct: 20 GRVLVVGAGGIGCEL 34 >3KYC-B nrPDB Length = 660 Score = 29.5 bits (65), Expect = 3.9, Method: Composition-based stats. Identities = 8/15 (53%), Positives = 12/15 (80%) Query: 214 EKMVVIGAGVIGVEL 228 +++V+GAG IG EL Sbjct: 38 GRVLVVGAGGIGCEL 52 >2X3N-A nrPDB Length = 399 Score = 29.5 bits (65), Expect = 3.9, Method: Composition-based stats. Identities = 16/86 (18%), Positives = 31/86 (36%), Gaps = 8/86 (9%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL 274 +++ G G+ G L + R G V VE E + N +L+ G + Sbjct: 8 DVLINGCGIGGAMLAYLLGRQGHRVVVVEQARR--------ERAINGADLLKPAGIRVVE 59 Query: 275 NTKVTGATKKSDGKIDVSIEAASGGK 300 + + G++ +E G+ Sbjct: 60 AAGLLAEVTRRGGRVRHELEVYHDGE 85 >5EB4-A nrPDB Length = 532 Score = 29.5 bits (65), Expect = 4.0, Method: Composition-based stats. Identities = 9/32 (28%), Positives = 15/32 (46%), Gaps = 1/32 (3%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKN 73 D VIG G G A ++ +K + +E+ Sbjct: 27 YDYIVIGGGTSGCPLAATLSE-KYKVLLLERG 57 >5PGZ-A nrPDB Length = 276 Score = 29.1 bits (64), Expect = 4.1, Method: Composition-based stats. Identities = 10/35 (28%), Positives = 16/35 (45%), Gaps = 1/35 (2%) Query: 214 EKMVVIGAGV-IGVELGSVWQRLGADVTAVEFLGH 247 +K++V GA IG E+ ++GA V Sbjct: 19 KKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEE 53 >5Y77-A nrPDB Length = 473 Score = 29.1 bits (64), Expect = 4.3, Method: Composition-based stats. Identities = 10/33 (30%), Positives = 17/33 (51%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNE 74 VT+IG+G G + A A+ G++ E+ Sbjct: 9 RQVTIIGAGLAGTLVARLLARNGWQVNLFERRP 41 >3I6D-A nrPDB Length = 470 Score = 29.1 bits (64), Expect = 4.5, Method: Composition-based stats. Identities = 11/41 (26%), Positives = 17/41 (41%), Gaps = 6/41 (14%) Query: 44 VTVIGSGPGGYVAAIKAAQ------LGFKTVCIEKNETLGG 78 V +IG G G AA + L + +E + +GG Sbjct: 8 VVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASPRVGG 48 Score = 28.4 bits (62), Expect = 7.4, Method: Composition-based stats. Identities = 12/45 (26%), Positives = 22/45 (48%), Gaps = 8/45 (17%) Query: 214 EKMVVIGAGVIGVELGSVW-------QRLGADVTAVEFLGHVGGV 251 + +V+IG G+ G+ + + + L ++T VE VGG Sbjct: 6 KHVVIIGGGITGL-AAAFYMEKEIKEKNLPLELTLVEASPRVGGK 49 >2EW2-A nrPDB Length = 316 Score = 29.1 bits (64), Expect = 4.5, Method: Composition-based stats. Identities = 11/29 (37%), Positives = 18/29 (62%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVE 243 K+ + GAG +G LG + + G DVT ++ Sbjct: 5 KIAIAGAGAMGSRLGIMLHQGGNDVTLID 33 >2CDC-A nrPDB Length = 366 Score = 29.1 bits (64), Expect = 4.7, Method: Composition-based stats. Identities = 9/26 (34%), Positives = 16/26 (61%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADV 239 K++V+G G IGV +++ G +V Sbjct: 182 RKVLVVGTGPIGVLFTLLFRTYGLEV 207 >4YNU-A nrPDB Length = 571 Score = 29.1 bits (64), Expect = 4.9, Method: Composition-based stats. Identities = 8/40 (20%), Positives = 16/40 (40%), Gaps = 1/40 (2%) Query: 38 QPIDADVTVIGSGPGGYVAAIKAAQL-GFKTVCIEKNETL 76 D V+G G G V A + ++ + +E ++ Sbjct: 2 NTTTYDYIVVGGGTSGLVVANRLSENPDVSVLLLEAGASV 41 >3LLV-A nrPDB Length = 141 Score = 29.1 bits (64), Expect = 5.1, Method: Composition-based stats. Identities = 8/33 (24%), Positives = 15/33 (45%) Query: 42 ADVTVIGSGPGGYVAAIKAAQLGFKTVCIEKNE 74 + VIGS G + G K + ++K++ Sbjct: 7 YEYIVIGSEAAGVGLVRELTAAGKKVLAVDKSK 39 >4G65-A nrPDB Length = 461 Score = 29.1 bits (64), Expect = 5.2, Method: Composition-based stats. Identities = 21/129 (16%), Positives = 38/129 (29%), Gaps = 11/129 (8%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL 274 K++++GAG +G L D+T V+ D + + Q + Sbjct: 5 KIIILGAGQVGGTLAENLVGENNDITIVDK---------DGDRLRELQDKYDLRVVNGHA 55 Query: 275 NTK-VTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCI-GRRPFTKNLGLEELGIELD 332 + V D + V++ L R ++ L Sbjct: 56 SHPDVLHEAGAQDADMLVAVTNTDETNMAACQVAFTLFNTPNRIARIRSPQYLAQKEALF 115 Query: 333 PRGRIPVNT 341 G IPV+ Sbjct: 116 KSGAIPVDH 124 >2AP9-A nrPDB Length = 299 Score = 29.1 bits (64), Expect = 5.2, Method: Composition-based stats. Identities = 24/134 (17%), Positives = 48/134 (35%), Gaps = 20/134 (14%) Query: 216 MVVIGAGVIGVELGSVWQRLGAD--------VTAVEFLGHVGGVGIDMEISKNFQRILQK 267 +VV G G ++ ++ +RLG + VT E L V ++ + ++ Sbjct: 61 VVVHGGGP---QITAMLRRLGIEGDFKGGFRVTTPEVLDVARMVLF-GQVGRELVNLINA 116 Query: 268 QGFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVL-------LVCIGRRPFTK 320 G + + A + + V+++ + V D + LV GR P Sbjct: 117 HG-PYAVGITGEDAQLFTAVRRSVTVDGVATDIGLVGDVDQVNTAAMLDLVAAGRIPVVS 175 Query: 321 NLGLEELGIELDPR 334 L + G+ + Sbjct: 176 TLAPDADGVVHNIN 189 >4DIO-A nrPDB Length = 405 Score = 29.1 bits (64), Expect = 5.3, Method: Composition-based stats. Identities = 19/77 (24%), Positives = 36/77 (46%), Gaps = 5/77 (6%) Query: 215 KMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFKL 274 K+ V+GAGV G++ + +RLGA V+A + +++ + + + +FK Sbjct: 192 KIFVMGAGVAGLQAIATARRLGAVVSATDVRPAAK-----EQVASLGAKFIAVEDEEFKA 246 Query: 275 NTKVTGATKKSDGKIDV 291 G K+ G+ V Sbjct: 247 AETAGGYAKEMSGEYQV 263 >4CPD-A nrPDB Length = 347 Score = 29.1 bits (64), Expect = 5.3, Method: Composition-based stats. Identities = 13/30 (43%), Positives = 18/30 (60%), Gaps = 1/30 (3%) Query: 44 VTVIGSGPGGYVAAIKAAQLGF-KTVCIEK 72 V VIG+GP G +A A LG K + I++ Sbjct: 172 VAVIGAGPVGLMAIEVAQVLGASKILAIDR 201 >2CUL-A nrPDB Length = 232 Score = 28.7 bits (63), Expect = 5.6, Method: Composition-based stats. Identities = 7/27 (25%), Positives = 13/27 (48%) Query: 216 MVVIGAGVIGVELGSVWQRLGADVTAV 242 ++++GAG G E + G V + Sbjct: 6 VLIVGAGFSGAETAFWLAQKGVRVGLL 32 >2B76-A nrPDB Length = 602 Score = 28.7 bits (63), Expect = 5.7, Method: Composition-based stats. Identities = 6/22 (27%), Positives = 13/22 (59%) Query: 335 GRIPVNTRFQTKIPNIYAIGDV 356 G I + +T+I ++A+G+ Sbjct: 360 GGIETDQNCETRIKGLFAVGEC 381 >4D3F-A nrPDB Length = 310 Score = 28.7 bits (63), Expect = 6.1, Method: Composition-based stats. Identities = 9/29 (31%), Positives = 14/29 (48%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAV 242 + + VIG G +G + V+ G VT Sbjct: 22 KSVTVIGLGPMGQAMADVFLEYGYSVTVW 50 >3WSV-A nrPDB Length = 322 Score = 28.7 bits (63), Expect = 6.6, Method: Composition-based stats. Identities = 27/181 (14%), Positives = 58/181 (32%), Gaps = 34/181 (18%) Query: 209 LKKVPEKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQ 268 +KK K+V++G G +G + G + + ++ E + + Sbjct: 1 MKKTSRKVVIVGTGFVGTSIAYAMINQGV-------ANELVLIDVNQE---------KAE 44 Query: 269 GFKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIGR--RPFTKNLGLEE 326 G L + K + SG E +++++ G +P L L + Sbjct: 45 GEALDLLDGMAWGEKN--------VSVWSGTYEECQDANLVILTAGVNQKPGQTRLDLVK 96 Query: 327 LGIELDPRGRIPVNTRFQTKIPNIYAIGDVVAGPM--LAHKAEDEGIICVEGMAGGAVHI 384 + + V + I+ V + P+ L + E + + G + Sbjct: 97 TNATITRQ---IVKEVMASGFDGIFV---VASNPVDILTYLTWQESGLPASRVVGTGTTL 150 Query: 385 D 385 D Sbjct: 151 D 151 >3MOG-A nrPDB Length = 483 Score = 28.7 bits (63), Expect = 6.6, Method: Composition-based stats. Identities = 15/73 (20%), Positives = 26/73 (35%), Gaps = 14/73 (19%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFK 273 + + VIG+G +G + V G V + ID G + Sbjct: 6 QTVAVIGSGTMGAGIAEVAASHGHQVLLYDISAEALTRAID--------------GIHAR 51 Query: 274 LNTKVTGATKKSD 286 LN++VT ++ Sbjct: 52 LNSRVTRGKLTAE 64 >1GPE-A nrPDB Length = 587 Score = 28.7 bits (63), Expect = 6.8, Method: Composition-based stats. Identities = 10/33 (30%), Positives = 13/33 (39%), Gaps = 1/33 (3%) Query: 42 ADVTVIGSGPGGYVAAIKAAQL-GFKTVCIEKN 73 D + G G G A K + K + IEK Sbjct: 25 YDYIIAGGGLTGLTVAAKLTENPKIKVLVIEKG 57 >6IUM-B nrPDB Length = 701 Score = 28.4 bits (62), Expect = 7.4, Method: Composition-based stats. Identities = 16/100 (16%), Positives = 33/100 (33%), Gaps = 13/100 (13%) Query: 214 EKMVVIGAGVIGVELGSVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQKQGFKFK 273 EK+ VIGAG +G + + G VT +E G ++ + K Sbjct: 293 EKVAVIGAGTMGGGISMNFLNAGIPVTILETKQEALDRG-----VGIIRKNYENSA---K 344 Query: 274 LNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCI 313 ++ G + ++ D+++ + Sbjct: 345 KGKLTQEKVEQRMGLLSTTLSYDDLK-----DADLIIEAV 379 >3GNQ-A nrPDB Length = 344 Score = 28.0 bits (61), Expect = 9.1, Method: Composition-based stats. Identities = 13/84 (15%), Positives = 27/84 (32%), Gaps = 5/84 (5%) Query: 128 STAVKALTGGIAHLFKQNKVVHVNGYGKITGKNQVTATKADGGTQVIDTKNILIATGSEV 187 + A+ + + +GK G+ DG V++ I + Sbjct: 37 DLEIVAINDLGDAKTNAHLTQYDTAHGKFPGE-----VSVDGDYLVVNGDRIRVLANRNP 91 Query: 188 TPFPGITIDEDTIVSSTGALSLKK 211 P + D ++ TG + K+ Sbjct: 92 AELPWGELGVDVVMECTGFFTSKE 115 >1Y6J-A nrPDB Length = 318 Score = 28.0 bits (61), Expect = 9.1, Method: Composition-based stats. Identities = 20/125 (16%), Positives = 40/125 (32%), Gaps = 33/125 (26%) Query: 214 EKMVVIGAGVIGVELG--SVWQRLGADVTAVEFLGHVGGVGIDMEISKNFQRILQ-KQGF 270 K+ +IGAG +G ++ ++ ++ K + G Sbjct: 8 SKVAIIGAGFVGASAAFTMALRQTANELVLIDVFKE-----------KAIGEAMDINHGL 56 Query: 271 KFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVLLVCIG--RRPFTKNLGLEELG 328 F + +G ++V CDV++V G R+P L L + Sbjct: 57 PFM-----------------GQMSLYAGDYSDVKDCDVIVVTAGANRKPGETRLDLAKKN 99 Query: 329 IELDP 333 + + Sbjct: 100 VMIAK 104 >5VM2-A nrPDB Length = 347 Score = 28.0 bits (61), Expect = 9.7, Method: Composition-based stats. Identities = 22/128 (17%), Positives = 48/128 (37%), Gaps = 14/128 (10%) Query: 211 KVPEKMVVIGAGVIGVELGSVWQRLGA-DVTAVEFLGHVGGVGIDMEISKNFQRILQKQG 269 K +K++++GAG IG+ + LGA ++ V+ L +++ + G Sbjct: 167 KPGKKIIILGAGCIGLMTLQACKCLGATEIAVVDVLEKRLA------MAEQLGATVVING 220 Query: 270 FKFKLNTKVTGATKKSDGKIDVSIEAASGGKAEVITCDVL-----LVCIGRRPFTKNLGL 324 K + T+ D D+ E A ++ ++ +G P + Sbjct: 221 AKEDTIARCQQFTE--DMGADIVFETAGSAVTVKQAPYLVMRGGKIMIVGTVPGASAINF 278 Query: 325 EELGIELD 332 ++ E+ Sbjct: 279 LKINREVT 286 >2QK4-A nrPDB Length = 452 Score = 28.0 bits (61), Expect = 9.8, Method: Composition-based stats. Identities = 15/44 (34%), Positives = 19/44 (43%), Gaps = 2/44 (4%) Query: 38 QPIDADVTVIGSGPGGYVAAIKAAQ-LGFKTVCIEKNETLGGTC 80 Q + A V +IGSG + A K AQ K V + G C Sbjct: 21 QSMAARVLIIGSGGREHTLAWKLAQSHHVKQVLVAPGNA-GTAC 63 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.314 0.147 0.407 Lambda K H 0.267 0.0450 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 20,920,975 Number of Sequences: 36641 Number of extensions: 945853 Number of successful extensions: 5413 Number of sequences better than 10.0: 378 Number of HSP's better than 10.0 without gapping: 435 Number of HSP's successfully gapped in prelim test: 110 Number of HSP's that attempted gapping in prelim test: 3613 Number of HSP's gapped (non-prelim): 967 length of query: 509 length of database: 10,336,785 effective HSP length: 101 effective length of query: 408 effective length of database: 6,636,044 effective search space: 2707505952 effective search space used: 2707505952 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 62 (28.4 bits)