BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P09147 (338 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1UDA-A nrPDB 701 0.0 1I3M-A nrPDB 376 e-105 3ENK-A nrPDB 365 e-101 4LIS-A nrPDB 343 5e-95 1Z45-A nrPDB 336 8e-93 1GY8-A nrPDB 225 2e-59 2C20-A nrPDB 220 5e-58 4WOK-A nrPDB 217 4e-57 6BI4-A nrPDB 105 4e-23 1ORR-A nrPDB 105 4e-23 6BWL-A nrPDB 101 4e-22 3RUE-A nrPDB 100 1e-21 2HUN-A nrPDB 98 4e-21 1R66-A nrPDB 93 2e-19 1KEU-A nrPDB 88 6e-18 2PZM-A nrPDB 86 2e-17 1BXK-A nrPDB 82 2e-16 2Q1T-A nrPDB 79 2e-15 2Q1W-A nrPDB 73 2e-13 2PK3-A nrPDB 66 3e-11 1OC2-A nrPDB 64 7e-11 3SXP-A nrPDB 64 7e-11 6GPK-A nrPDB 64 8e-11 1DB3-A nrPDB 63 2e-10 4EJ0-A nrPDB 61 9e-10 3M2P-A nrPDB 60 1e-09 2Z95-A nrPDB 59 2e-09 5UZH-A nrPDB 55 6e-08 1RKX-A nrPDB 53 2e-07 1WVG-A nrPDB 53 2e-07 1EQ2-A nrPDB 52 4e-07 2X86-A nrPDB 51 8e-07 4WKG-A nrPDB 49 2e-06 2C54-A nrPDB 49 2e-06 1ZZE-A nrPDB 46 2e-05 6GCS-E nrPDB 45 7e-05 2GN9-A nrPDB 40 0.001 4QUK-A nrPDB 39 0.003 1GFS-A nrPDB 39 0.004 2QYS-A nrPDB 38 0.005 4G5H-A nrPDB 38 0.006 5B6K-A nrPDB 38 0.007 5U9C-A nrPDB 38 0.008 4KTT-E nrPDB 37 0.011 2P4H-X nrPDB 37 0.016 1VL0-A nrPDB 36 0.022 1QYC-A nrPDB 36 0.025 3RFT-A nrPDB 35 0.040 4R1U-A nrPDB 35 0.046 4RHE-A nrPDB 34 0.079 2NNL-D nrPDB 34 0.10 1DIR-A nrPDB 34 0.11 3OIC-A nrPDB 34 0.11 4R1T-A nrPDB 33 0.13 4PVC-A nrPDB 33 0.23 3PXX-A nrPDB 33 0.23 3WTC-A nrPDB 33 0.25 2QV3-A nrPDB 32 0.36 4B4O-A nrPDB 32 0.45 3WOH-A nrPDB 32 0.57 3SLK-A nrPDB 31 0.61 3R3S-A nrPDB 31 0.68 2Q2Q-A nrPDB 31 0.76 6NYJ-A nrPDB 31 0.86 1KO7-A nrPDB 31 0.97 5ZVG-B nrPDB 31 0.99 1QYD-A nrPDB 30 1.0 3SC6-A nrPDB 30 1.1 5ILO-A nrPDB 30 1.1 5YWN-A nrPDB 29 2.9 1JB1-A nrPDB 29 3.2 5IZL-A nrPDB 28 4.6 1HE4-A nrPDB 28 4.9 4NPH-A nrPDB 28 5.1 4AVY-A nrPDB 28 5.6 1JAY-A nrPDB 28 6.5 1B65-A nrPDB 28 6.9 >1UDA-A nrPDB Length = 338 Score = 701 bits (1810), Expect = 0.0, Method: Compositional matrix adjust. Identities = 337/338 (99%), Positives = 337/338 (99%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI Sbjct: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120 Query: 121 FSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNP 180 FSSSATVYGD PKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNP Sbjct: 121 FSSSATVYGDNPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNP 180 Query: 181 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA 240 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA Sbjct: 181 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA 240 Query: 241 DGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDLPAYW 300 DGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDLPAYW Sbjct: 241 DGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDLPAYW 300 Query: 301 ADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGYPD 338 ADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGYPD Sbjct: 301 ADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGYPD 338 >1I3M-A nrPDB Length = 348 Score = 376 bits (965), Expect = e-105, Method: Compositional matrix adjust. Identities = 178/341 (52%), Positives = 236/341 (69%), Gaps = 6/341 (1%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKR------SVLPVIERLGGKHPTFV 55 +VLVTGG+GYIGSHT ++LL+ G+ +++DN N+ R L ++ L G+ F Sbjct: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 Query: 56 EGDIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAAN 115 E DI ++ + + ++ VIHFAGLKA+GESVQKPL+YY N+ GT++L+ M+A Sbjct: 64 EMDILDQGALQRLFKKYSFMAVIHFAGLKAMGESVQKPLDYYRVNLTGTIQLLEIMKAHG 123 Query: 116 VKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALL 175 VKN +FSSSATVYG+ +P E+ PTG +PYGKSK +E+++ DL +A W++ LL Sbjct: 124 VKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNVVLL 183 Query: 176 RYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIH 235 RYFNP GAH SG +GEDPQGIPNNLMPY++QVA+GRR++L +FGNDY TEDGTGVRDYIH Sbjct: 184 RYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIH 243 Query: 236 VMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGD 295 V+DLA GH+ A+ KL + G IYNLG G G SVL +V A KA GK + Y RREGD Sbjct: 244 VVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGD 303 Query: 296 LPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGY 336 + A +A+ S A EL W LD M +D W WQ ++P G+ Sbjct: 304 VAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGF 344 >3ENK-A nrPDB Length = 341 Score = 365 bits (937), Expect = e-101, Method: Compositional matrix adjust. Identities = 180/334 (53%), Positives = 229/334 (68%), Gaps = 1/334 (0%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 +LVTGG+GYIGSHT V+LL +G+DV+I DNL NSKR + IE++ GK P F E D+ +E Sbjct: 8 ILVTGGAGYIGSHTAVELLAHGYDVVIADNLVNSKREAIARIEKITGKTPAFHETDVSDE 67 Query: 63 ALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFS 122 + I H I IHFA LKAVGESV KP+EYY NN++ L L+ MR VK +FS Sbjct: 68 RALARIFDAHPITAAIHFAALKAVGESVAKPIEYYRNNLDSLLSLLRVMRERAVKRIVFS 127 Query: 123 SSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNPVG 182 SSATVYG + P E+FP + +PYG++KLM EQIL D++ A P W +A LRYFNPVG Sbjct: 128 SSATVYGVPERSPIDETFPL-SATNPYGQTKLMAEQILRDVEAADPSWRVATLRYFNPVG 186 Query: 183 AHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLADG 242 AH SG +GEDP GIPNNLMPY+AQVAVG+ + L +FG+DYPT DGTGVRDYIHV+DLA G Sbjct: 187 AHESGLIGEDPAGIPNNLMPYVAQVAVGKLEKLRVFGSDYPTPDGTGVRDYIHVVDLARG 246 Query: 243 HVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDLPAYWAD 302 H+ A++ L + NLG G G SVL+VV AF KA G+ V Y RR GD+ +A+ Sbjct: 247 HIAALDALERRDASLTVNLGTGRGYSVLEVVRAFEKASGRAVPYELVARRPGDVAECYAN 306 Query: 303 ASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGY 336 + A + W+ R L+ M D W WQ +P+G+ Sbjct: 307 PAAAAETIGWKAERDLERMCADHWRWQENNPRGF 340 >4LIS-A nrPDB Length = 371 Score = 343 bits (881), Expect = 5e-95, Method: Compositional matrix adjust. Identities = 175/353 (49%), Positives = 234/353 (66%), Gaps = 20/353 (5%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 VLVTGG+GYIGS T + LL+ G+ V++ DNL NS L IE + GK F + D+ +E Sbjct: 6 VLVTGGTGYIGSFTTLALLEAGYKVVVADNLYNSSAEALNRIELISGKKAEFAQLDVTDE 65 Query: 63 ALMTEILHDHA-IDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIF 121 A ++ H ID+VIHFA LKAVGES +KPL+YY NV GT+ L+ +M NV N +F Sbjct: 66 AAFDKVFEAHPDIDSVIHFAALKAVGESGEKPLDYYHVNVYGTICLLRSMVRHNVTNIVF 125 Query: 122 SSSATVYGDQPK----IPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPD-------- 169 SSSATVYGD + IP E P G P +PYG +K +E +TD+ AQ + Sbjct: 126 SSSATVYGDATRFPDMIPIPEHCPLG-PTNPYGNTKFAIELAITDVINAQRNNAKKAGNE 184 Query: 170 -----WSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPT 224 W+ ALLRYFNP GAHPSG MGEDPQG+P NL+P +AQVA G+R+ L +FG+DY + Sbjct: 185 TEAAKWNGALLRYFNPAGAHPSGIMGEDPQGVPYNLLPLLAQVATGKREKLLVFGDDYAS 244 Query: 225 EDGTGVRDYIHVMDLADGHVVAMEKL-ANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKP 283 DGT +RDYIH++DLADGH+ A+ L AN PGV +NLG G G++V +++ AFSKA G+ Sbjct: 245 HDGTAIRDYIHILDLADGHLKALNYLRANNPGVRAWNLGTGRGSTVYEMIRAFSKAVGRD 304 Query: 284 VNYHFAPRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGY 336 + Y APRR GD+ ++ ++A+ EL W+ RTL++ +D W W +PQGY Sbjct: 305 LPYEVAPRRAGDVLNLTSNPTRANTELGWKAQRTLEQACEDLWLWTKNNPQGY 357 >1Z45-A nrPDB Length = 699 Score = 336 bits (862), Expect = 8e-93, Method: Compositional matrix adjust. Identities = 169/343 (49%), Positives = 227/343 (66%), Gaps = 10/343 (2%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 VLVTGG+GYIGSHT V+L++NG+D ++ DNL NS + +E L H F E D+ + Sbjct: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCDR 73 Query: 63 ALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFS 122 + ++ ++ ID+VIHFAGLKAVGES Q PL YY NN+ GT+ L+ M+ NV F+FS Sbjct: 74 KGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKFVFS 133 Query: 123 SSATVYGDQPK----IPYVESFPTGTPQSPYGKSKLMVEQILTDLQKA-QPDWSIALLRY 177 SSATVYGD + IP E P G P +PYG +K +E IL DL + + W A+LRY Sbjct: 134 SSATVYGDATRFPNMIPIPEECPLG-PTNPYGHTKYAIENILNDLYNSDKKSWKFAILRY 192 Query: 178 FNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVM 237 FNP+GAHPSG +GEDP GIPNNL+PY+AQVAVGRR+ L IFG+DY + DGT +RDYIHV+ Sbjct: 193 FNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDYIHVV 252 Query: 238 DLADGHVVAMEKL----ANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRRE 293 DLA GH+ A++ L N+ +NLG+G G++V +V +AF KA G + Y RR Sbjct: 253 DLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYKVTGRRA 312 Query: 294 GDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGY 336 GD+ A +A REL W+ +++ +D W W + +P GY Sbjct: 313 GDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGY 355 >1GY8-A nrPDB Length = 397 Score = 225 bits (574), Expect = 2e-59, Method: Compositional matrix adjust. Identities = 150/386 (38%), Positives = 204/386 (52%), Gaps = 56/386 (14%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQN-GHDVIILDNLC---------NSKRSVLPVIERLGGK 50 MRVLV GG+GYIGSH LL++ H V+I+D+L ++ +V +++ G Sbjct: 3 MRVLVCGGAGYIGSHFVRALLRDTNHSVVIVDSLVGTHGKSDHVETRENVARKLQQSDGP 62 Query: 51 HPTFVE-------GDIRNEALMTEILHDHA-IDTVIHFAGLKAVGESVQKPLEYYDNNVN 102 P + + GD+RNE + + H ID V+H AVGESV+ PL+YYDNNV Sbjct: 63 KPPWADRYAALEVGDVRNEDFLNGVFTRHGPIDAVVHMCAFLAVGESVRDPLKYYDNNVV 122 Query: 103 GTLRLISAMRAANVKNFIFSSSATVYGDQPKIPYVESFPTG----------TPQSPYGKS 152 G LRL+ AM IFSSSA ++G+ P + S T +P+SPYG+S Sbjct: 123 GILRLLQAMLLHKCDKIIFSSSAAIFGN----PTMGSVSTNAEPIDINAKKSPESPYGES 178 Query: 153 KLMVEQILTDLQKAQPDWSIALLRYFNPVGAHPSGDMGEDPQG----IPNNLMPYIAQVA 208 KL+ E+++ D +A I LRYFN GAH GD+GE QG IP L ++ +A Sbjct: 179 KLIAERMIRDCAEAYGIKGIC-LRYFNACGAHEDGDIGEHYQGSTHLIPIILGRVMSDIA 237 Query: 209 VGRR----------DSLAIFGNDYPTEDGTGVRDYIHVMDLADGHVVAM---EKLA---N 252 +R + IFG DYPT DGT VRDY+HV DLA H++A+ EKL Sbjct: 238 PDQRLTIHEDASTDKRMPIFGTDYPTPDGTCVRDYVHVCDLASAHILALDYVEKLGPNDK 297 Query: 253 KPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDLPAYWADASKADRE-LN 311 ++NLG G SV +V+ K G P+ RREGD PAY AS RE L Sbjct: 298 SKYFSVFNLGTSRGYSVREVIEVARKTTGHPIPVRECGRREGD-PAYLVAASDKAREVLG 356 Query: 312 WRVT-RTLDEMAQDTWHWQSRHPQGY 336 W+ TL+ + + +W +Q HP GY Sbjct: 357 WKPKYDTLEAIMETSWKFQRTHPNGY 382 >2C20-A nrPDB Length = 330 Score = 220 bits (561), Expect = 5e-58, Method: Compositional matrix adjust. Identities = 120/335 (35%), Positives = 184/335 (54%), Gaps = 11/335 (3%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 +L+ GG+GYIGSH +L+ G V+++DNL + + F GD+R++ Sbjct: 4 ILICGGAGYIGSHAVKKLVDEGLSVVVVDNLQTGHEDAIT-------EGAKFYNGDLRDK 56 Query: 63 ALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFS 122 A + ++ I+ V+HFA VG S++KPL+YY+NNV G L L+ M V FIFS Sbjct: 57 AFLRDVFTQENIEAVMHFAADSLVGVSMEKPLQYYNNNVYGALCLLEVMDEFKVDKFIFS 116 Query: 123 SSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNPVG 182 S+A YG + + + P + YG++KL +E++L +A + + RYFN G Sbjct: 117 STAATYG-EVDVDLITEETMTNPTNTYGETKLAIEKMLHWYSQAS-NLRYKIFRYFNVAG 174 Query: 183 AHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLADG 242 A P+G +GED + +L+P + QVA+G+R+ + +FG+DY T DGT +RDYIHV DL Sbjct: 175 ATPNGIIGEDHRP-ETHLIPLVLQVALGQREKIMMFGDDYNTPDGTCIRDYIHVEDLVAA 233 Query: 243 HVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDLPAYWAD 302 H + ++ L N YNLG G G SV ++V+A + + APRR GD A Sbjct: 234 HFLGLKDLQNGGESDFYNLGNGNGFSVKEIVDAVREVTNHEIPAEVAPRRAGDPARLVAS 293 Query: 303 ASKADRELNWRVTRT-LDEMAQDTWHWQSRHPQGY 336 + KA +L W + + + W+W + P GY Sbjct: 294 SQKAKEKLGWDPRYVNVKTIIEHAWNWHQKQPNGY 328 >4WOK-A nrPDB Length = 336 Score = 217 bits (553), Expect = 4e-57, Method: Compositional matrix adjust. Identities = 130/312 (41%), Positives = 175/312 (56%), Gaps = 15/312 (4%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 VLV GG+G+IGSHT L G+ ++ DNL +S + R G FVEGDI ++ Sbjct: 14 VLVVGGAGFIGSHTAKLLAGQGYAPVVYDNLSTGHQSAV----RWG----DFVEGDILDQ 65 Query: 63 ALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFS 122 A + E + +A VIHFA VGESV+ P +YY NNV GT L+ A R +N IFS Sbjct: 66 ARLVETMEKYAPVAVIHFAASAYVGESVEDPAKYYRNNVGGTQSLLDACRLTRTQNVIFS 125 Query: 123 SSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNPVG 182 SS YG ++P E P +PYG++KL+ E +L D A +AL RYFN G Sbjct: 126 SSCATYGVPSRLPIGEG-EAQNPINPYGRTKLIAEHMLADYAVAYGLRYVAL-RYFNASG 183 Query: 183 AHPSGDMGE--DPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA 240 A G++GE DP+ +L+P A GR D L ++G+DY T DGT +RDYIHV DLA Sbjct: 184 ADIDGELGEKHDPE---THLIPRAMMAAAGRLDVLEVYGDDYETPDGTCIRDYIHVTDLA 240 Query: 241 DGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDLPAYW 300 HV+A+E L G NLG G G S+ ++V + + G+ V RR GD PA + Sbjct: 241 RAHVLAVEHLKEAGGNLAVNLGTGRGTSIREIVQSIGRLTGRSVPVAMRARRAGDPPALY 300 Query: 301 ADASKADRELNW 312 AD + A +L + Sbjct: 301 ADPALAAEKLGF 312 >6BI4-A nrPDB Length = 346 Score = 105 bits (261), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 92/341 (26%), Positives = 155/341 (45%), Gaps = 33/341 (9%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQN--GHDVIILDNLCNSKRSVLPVIERLGGKHPT--FVE 56 M +LVTGG+G+IGS+ +LQ+ + +I D L S L ++ + HP FV+ Sbjct: 25 MNILVTGGAGFIGSNFVHYMLQSYETYKIINFDALTYSGN--LNNVKSIQ-DHPNYYFVK 81 Query: 57 GDIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANV 116 G+I+N L+ ++ + + +++FA V S++ P+ +YD NV GT+ L+ ++ Sbjct: 82 GEIQNGELLEHVIKERDVQVIVNFAAESHVDRSIENPIPFYDTNVIGTVTLLELVKKYPH 141 Query: 117 KNFIFSSSATVYGDQPKI-PYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALL 175 + S+ VYG K + E P P SPY SK + I K + + Sbjct: 142 IKLVQVSTDEVYGSLGKTGRFTEETPLA-PNSPYSSSKASADMIALAYYKTY-QLPVIVT 199 Query: 176 RYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIH 235 R N G P P L+P + A+ + L ++G DG VRD++H Sbjct: 200 RCSNNYG----------PYQYPEKLIPLMVTNALEGK-KLPLYG------DGLNVRDWLH 242 Query: 236 VMDLADGHVVAMEKLANKPGV-HIYNLGAGVGNSVLDVVNAFSKACGK-PVNYHFAPRRE 293 V D H A++ + +K V +YN+G + ++VV GK + + R Sbjct: 243 VTD----HCSAIDVVLHKGRVGEVYNIGGNNEKTNVEVVEQIITLLGKTKKDIEYVTDRL 298 Query: 294 GDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQ 334 G Y +A K E +W T ++ Q+T W ++ + Sbjct: 299 GHDRRYAINAEKMKNEFDWEPKYTFEQGLQETVQWYEKNEE 339 >1ORR-A nrPDB Length = 347 Score = 105 bits (261), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 97/354 (27%), Positives = 152/354 (42%), Gaps = 44/354 (12%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSV---LPVIERLGGKHPTFVEGD 58 ++L+TGG G++GS+ L G D+I+ DNL S++ L + LG + FV GD Sbjct: 3 KLLITGGCGFLGSNLASFALSQGIDLIVFDNL--SRKGATDNLHWLSSLG--NFEFVHGD 58 Query: 59 IRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVK- 117 IRN+ +T ++ + D+ H AG A+ S+ P ++ NV GTL L+ A+R N Sbjct: 59 IRNKNDVTRLITKYMPDSCFHLAGQVAMTTSIDNPCMDFEINVGGTLNLLEAVRQYNSNC 118 Query: 118 NFIFSSSATVYGDQPKIPYVES--------FPTGTPQ-------SPYGKSKLMVEQILTD 162 N I+SS+ VYGD + Y E+ P G + SPYG SK +Q + D Sbjct: 119 NIIYSSTNKVYGDLEQYKYNETETRYTCVDKPNGYDESTQLDFHSPYGCSKGAADQYMLD 178 Query: 163 LQKAQPDWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAV----GRRDSLAIF 218 + + V H S G + + Q AV G I Sbjct: 179 YAR--------IFGLNTVVFRHSSMYGGRQFATYDQGWVGWFCQKAVEIKNGINKPFTIS 230 Query: 219 GNDYPTEDGTGVRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSK 278 GN G VRD +H D+ + A+ ++ G + +N+G + NS+ + Sbjct: 231 GN------GKQVRDVLHAEDMISLYFTALANVSKIRG-NAFNIGGTIVNSLSLLELFKLL 283 Query: 279 A--CGKPVNYHFAPRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQS 330 C + + P RE D + AD K ++W + + Q + W S Sbjct: 284 EDYCNIDMRFTNLPVRESDQRVFVADIKKITNAIDWSPKVSAKDGVQKMYDWTS 337 >6BWL-A nrPDB Length = 328 Score = 101 bits (252), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 95/334 (28%), Positives = 146/334 (43%), Gaps = 32/334 (9%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRS-VLPVIERLGGKHPTFVEGDI 59 M++LVTGG+G+IG +LLQ+ H+V ILDNL NS + + L K ++GDI Sbjct: 1 MKILVTGGAGFIGRWVVKRLLQDKHEVWILDNLANSTTANITEFAHDLNLKQC--IQGDI 58 Query: 60 RNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNF 119 +++ L+ ++ +++ D H A V +S+ ++N+ GT L+ +VK Sbjct: 59 KDKKLVAQLFENNSFDLCYHLAASINVQDSIDDARATFENDTIGTFNLLEQCLNYDVK-M 117 Query: 120 IFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFN 179 +F S+ VY I + P SPY SK+ E ++ A + ++R FN Sbjct: 118 VFMSTCMVYDKATNIQGISELDPIKPASPYAGSKIAAENMVLSYYYAYK-LPVVVIRPFN 176 Query: 180 PVG-AHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMD 238 G +G G NN + + L I+G DG RD ++V D Sbjct: 177 TYGPFQKTGGEGGVVAIFINNKLDNV---------PLNIYG------DGKQTRDLLYVED 221 Query: 239 LADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNY----HFAPRREG 294 AD VVA A G HI N G G S+ + S G V+ H P+ E Sbjct: 222 CAD-FVVAAGYSAKANG-HIINAGTGQDISINKLAELIS---GNKVSIQHVTHIHPQSE- 275 Query: 295 DLPAYWADASKADRELNWRVTRTLDEMAQDTWHW 328 + + KA LNW +L++ T W Sbjct: 276 -IQKLLCNYEKAKTILNWEPKVSLEDGVIKTEEW 308 >3RUE-A nrPDB Length = 351 Score = 99.8 bits (247), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 93/345 (26%), Positives = 158/345 (45%), Gaps = 35/345 (10%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHP----TFVEGDI 59 L+TG +G+IGS+ +LL+ VI LDN + L ++ L F+EGDI Sbjct: 29 LITGVAGFIGSNLLEKLLKLNQVVIGLDNFSTGHQYNLDEVKTLVSTEQWSRFCFIEGDI 88 Query: 60 RNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNF 119 R+ +++ +D V+H A L +V S+ P+ N+ G L ++ A + A V++F Sbjct: 89 RDLTTCEQVMK--GVDHVLHQAALGSVPRSIVDPITTNATNITGFLNILHAAKNAQVQSF 146 Query: 120 IFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFN 179 +++S++ YGD P +P VE G P SPY +K V +I + + LRYFN Sbjct: 147 TYAASSSTYGDHPALPKVEE-NIGNPLSPYAVTK-YVNEIYAQVYARTYGFKTIGLRYFN 204 Query: 180 PVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGND-YPTEDGTGVRDYIHVMD 238 G +DP G ++P + + + G+D Y DG RD+ ++ + Sbjct: 205 VFGRR------QDPNGAYAAVIP--------KWTAAMLKGDDVYINGDGETSRDFCYIDN 250 Query: 239 LADGHVV-AMEKLANKPGVHIYNLGAG-------VGNSVLDVVNAFSKACGKPVNYHFAP 290 + +++ A+ K + K +IYN+ G + + D +N + Y Sbjct: 251 VIQMNILSALAKDSAKD--NIYNVAVGDRTTLNELSGYIYDELNLIHHIDKLSIKYR--E 306 Query: 291 RREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQG 335 R GD+ AD +KA L +R + E + + W R +G Sbjct: 307 FRSGDVRHSQADVTKAIDLLKYRPNIKIREGLRLSMPWYVRFLKG 351 >2HUN-A nrPDB Length = 336 Score = 98.2 bits (243), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 98/335 (29%), Positives = 152/335 (45%), Gaps = 35/335 (10%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHD--VIILDNL-CNSKRSVLPVIERLGGKHPTFVEG 57 M++LVTGG G+IGS+ +L+ D VI +D L S + L +E TFV+G Sbjct: 4 MKLLVTGGMGFIGSNFIRYILEKHPDWEVINIDKLGYGSNPANLKDLE--DDPRYTFVKG 61 Query: 58 DIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVK 117 D+ + L+ E++ +D V+H A V S+ P + +NV GT L+ ++R N + Sbjct: 62 DVADYELVKELVR--KVDGVVHLAAESHVDRSISSPEIFLHSNVIGTYTLLESIRRENPE 119 Query: 118 -NFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLR 176 F+ S+ VYGD K + E+ P SPY +K + ++ + R Sbjct: 120 VRFVHVSTDEVYGDILKGSFTEN-DRLMPSSPYSATKAASDMLV-----------LGWTR 167 Query: 177 YFNPVGAHPSGDMGEDPQGIPNNLMP-YIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIH 235 +N + P P L+P I + ++G + + I+G G VRD+++ Sbjct: 168 TYNLNASITRCTNNYGPYQFPEKLIPKTIIRASLGLK--IPIYGT------GKNVRDWLY 219 Query: 236 VMDLADGHVVAMEKLANK-PGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNY-HFAPRRE 293 V D HV A+E + K IYN+ AG + L+VV + GK R Sbjct: 220 VED----HVRAIELVLLKGESREIYNISAGEEKTNLEVVKIILRLMGKGEELIELVEDRP 275 Query: 294 GDLPAYWADASKADRELNWRVTRTLDEMAQDTWHW 328 G Y D+ K R+L WR T DE + T W Sbjct: 276 GHDLRYSLDSWKITRDLKWRPKYTFDEGIKKTIDW 310 >1R66-A nrPDB Length = 337 Score = 92.8 bits (229), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 95/341 (27%), Positives = 149/341 (43%), Gaps = 44/341 (12%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGH------DVIILDNL--CNSKRSVLPVIE--RLGGK 50 MR+LVTGG+G+IGSH QLL + +VI+LD+L ++ ++ PV RL Sbjct: 1 MRLLVTGGAGFIGSHFVRQLLAGAYPDVPADEVIVLDSLTYAGNRANLAPVDADPRL--- 57 Query: 51 HPTFVEGDIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISA 110 FV GDIR+ L+ L +D ++HFA V S+ + + NV GT L+ Sbjct: 58 --RFVHGDIRDAGLLARELR--GVDAIVHFAAESHVDRSIAGASVFTETNVQGTQTLLQC 113 Query: 111 MRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDW 170 A V + S+ VYG + ES P P SPY SK + + + Sbjct: 114 AVDAGVGRVVHVSTDEVYGSIDSGSWTESSPL-EPNSPYAASKAGSDLVARAYHRTY-GL 171 Query: 171 SIALLRYFNPVGAHPSGDMGEDPQGIPNNLMP-YIAQVAVGRRDSLAIFGNDYPTEDGTG 229 + + R N G P P L+P ++ + G +L ++G DG Sbjct: 172 DVRITRCCNNYG----------PYQHPEKLIPLFVTNLLDG--GTLPLYG------DGAN 213 Query: 230 VRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVN--YH 287 VR+++H D G +A+ + G IY++G G+ + ++ + G + Sbjct: 214 VREWVHTDDHCRG--IALVLAGGRAG-EIYHIGGGLELTNRELTGILLDSLGADWSSVRK 270 Query: 288 FAPRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHW 328 A R+ DL Y D K +REL +R + + T W Sbjct: 271 VADRKGHDL-RYSLDGGKIERELGYRPQVSFADGLARTVRW 310 >1KEU-A nrPDB Length = 361 Score = 87.8 bits (216), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 93/356 (26%), Positives = 147/356 (41%), Gaps = 51/356 (14%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 M++L+TGG+G+IGS +++N D ++ + ++ + + F DI Sbjct: 1 MKILITGGAGFIGSAVVRHIIKNTQDTVVNIDKLTYAGNLESLSDISESNRYNFEHADIC 60 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLI-------SAMRA 113 + A +T I + D V+H A V S+ P + + N+ GT L+ SA+ Sbjct: 61 DSAEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYALLEVARKYWSALGE 120 Query: 114 ANVKNFIFS--SSATVYGDQPKIPYVE---SFPTGT------PQSPYGKSKLMVEQILTD 162 NF F S+ VYGD P VE + P T P SPY SK + ++ Sbjct: 121 DKKNNFRFHHISTDEVYGDLPHPDEVENSVTLPLFTETTAYAPSSPYSASKASSDHLVRA 180 Query: 163 LQKAQPDWSIALLRYFNP-VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGND 221 ++ Y P + + S + G P P L+P + A+ + L I+G Sbjct: 181 WRRT----------YGLPTIVTNCSNNYG--PYHFPEKLIPLVILNALEGK-PLPIYGK- 226 Query: 222 YPTEDGTGVRDYIHVMDLADG-HVVAMEKLANKPGVHIYNLGAGVGNSVLDVV----NAF 276 G +RD+++V D A H+V E A + YN+G LDVV + Sbjct: 227 -----GDQIRDWLYVEDHARALHMVVTEGKAGE----TYNIGGHNEKKNLDVVFTICDLL 277 Query: 277 SKACGKPVNYH----FAPRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHW 328 + K +Y + R G Y DA K REL W+ T + + T W Sbjct: 278 DEIVPKATSYREQITYVADRPGHDRRYAIDAGKISRELGWKPLETFESGIRKTVEW 333 >2PZM-A nrPDB Length = 330 Score = 86.3 bits (212), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 86/339 (25%), Positives = 143/339 (42%), Gaps = 50/339 (14%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 MR+L+TGG+G +GS+ L GH+++++DN KR VLP + L + +EG + Sbjct: 21 MRILITGGAGCLGSNLIEHWLPQGHEILVIDNFATGKREVLPPVAGL-----SVIEGSVT 75 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDN---NVNGTLRLISAMRAANVK 117 + L+ V+H A + + P ++ ++ NV G++ + A A VK Sbjct: 76 DAGLLERAFDSFKPTHVVHSAA------AYKDPDDWAEDAATNVQGSINVAKAASKAGVK 129 Query: 118 NFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRY 177 + +A YG +P PT P + YG SK E L D + LR Sbjct: 130 RLLNFQTALCYGRPATVPIPIDSPTA-PFTSYGISKTAGEAFLM-----MSDVPVVSLRL 183 Query: 178 FNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVM 237 N G P +G P + ++ G++ F +D VRD+ + Sbjct: 184 ANVTG--PRLAIGPIPT--------FYKRLKAGQK----CFCSDT-------VRDF---L 219 Query: 238 DLADGHVVAMEKLANKPGVHIYNLGAGVGNS---VLDVVNAFSKAC-GKPVNYHFAPRRE 293 D++D +A L ++N+ G G+S V DVV + A +PV AP + Sbjct: 220 DMSDFLAIADLSLQEGRPTGVFNVSTGEGHSIKEVFDVVLDYVGATLAEPVPV-VAPGAD 278 Query: 294 GDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRH 332 D+P+ D SK + E W+ + W ++ Sbjct: 279 -DVPSVVLDPSKTETEFGWKAKVDFKDTITGQLAWYDKY 316 >1BXK-A nrPDB Length = 355 Score = 82.4 bits (202), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 94/354 (26%), Positives = 145/354 (40%), Gaps = 53/354 (14%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHD-VIILDNLCNSKR--SVLPVIERLGGKHPTFVEGD 58 ++L+TGG+G+IGS ++ D V+++D L + S+ PV + + F + D Sbjct: 3 KILITGGAGFIGSALVRYIINETSDAVVVVDKLTYAGNLMSLAPVAQ---SERFAFEKVD 59 Query: 59 IRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRA----- 113 I + A + + +H D V+H A V S+ P + + N+ GT L+ A RA Sbjct: 60 ICDRAELARVFTEHQPDCVMHLAAESHVDRSIDGPAAFIETNIVGTYTLLEAARAYWNAL 119 Query: 114 ----ANVKNFIFSSSATVYGDQPKIP--YVESFPTGTPQSPYGKSKLMVEQILTDLQKAQ 167 + F S+ VYGD + E+ P P SPY SK + ++ Sbjct: 120 TEDKKSAFRFHHISTDEVYGDLHSTDDFFTETTPYA-PSSPYSASKASSDHLVR------ 172 Query: 168 PDWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDG 227 A LR + + P P L+P + A+ + SL ++GN G Sbjct: 173 -----AWLRTYGLPTLITNCSNNYGPYHFPEKLIPLMILNALAGK-SLPVYGN------G 220 Query: 228 TGVRDYIHVMDLADGHVVAMEKLANKPGV-HIYNLGAGVGNSVLDVVNAFSK-----ACG 281 +RD+++V D H A+ +A V YN+G LDVV + A Sbjct: 221 QQIRDWLYVED----HARALYCVATTGKVGETYNIGGHNERKNLDVVETICELLEELAPN 276 Query: 282 KP---VNYH----FAPRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHW 328 KP +Y F R G Y DASK REL T + + T W Sbjct: 277 KPHGVAHYRDLITFVADRPGHDLRYAIDASKIARELGCVPQETFESGMRKTVQW 330 >2Q1T-A nrPDB Length = 377 Score = 79.3 bits (194), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 82/340 (24%), Positives = 144/340 (42%), Gaps = 35/340 (10%) Query: 3 VLVTGGSGYIGSHTCVQLLQNG-HDVIILDNLCNSKRSVLPVIERLGGKHPT--FVEGDI 59 V+V GG+G++GS+ +LL+ G + V ++DNL ++++ +P HP F E I Sbjct: 35 VMVVGGAGFVGSNLVKRLLELGVNQVHVVDNLLSAEKINVP-------DHPAVRFSETSI 87 Query: 60 RNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMR-AANVKN 118 ++AL+ + ++ D V H A S+ PL ++NN TL+L ++ +K Sbjct: 88 TDDALLASLQDEY--DYVFHLATYHGNQSSIHDPLADHENNTLTTLKLYERLKHFKRLKK 145 Query: 119 FIFSSSAT-----VYGDQPKIPYVESFPTGTPQSPYGKSKLMVE--QILTDLQKAQPDWS 171 ++S++ + D + SPY SK+ E + Q P Sbjct: 146 VVYSAAGCSIAEKTFDDAKATEETDIVSLHNNDSPYSMSKIFGEFYSVYYHKQHQLPTVR 205 Query: 172 IALLRYFNPVGAHPSGDMGEDPQGIPNNLMP-YIAQVAVGRRDSLAIFGNDYPTED-GTG 229 + P +G P + N+ P +I + A+ G P E+ G Sbjct: 206 ARFQNVYGPGEILGAGRWRGTPATVWRNVTPTFIYK---------ALKGMPLPLENGGVA 256 Query: 230 VRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFA 289 RD+I V D+A+G + PG +YN+ +G S+ D+ ++ G Sbjct: 257 TRDFIFVEDVANGLIACAAD--GTPG-GVYNIASGKETSIADLATKINEITGNNTELDRL 313 Query: 290 PRREGDLPA-YWADASKADRELNWRVTRTLDEMAQDTWHW 328 P+R D + KA REL + ++D+ + T W Sbjct: 314 PKRPWDNSGKRFGSPEKARRELGFSADVSIDDGLRKTIEW 353 >2Q1W-A nrPDB Length = 333 Score = 72.8 bits (177), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 79/317 (24%), Positives = 130/317 (41%), Gaps = 51/317 (16%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHP--TFVEGDI 59 +V +TG G IGSH LL+ G V+ +DN +R L HP TFVEG I Sbjct: 23 KVFITGICGQIGSHIAELLLERGDKVVGIDNFATGRREHLK-------DHPNLTFVEGSI 75 Query: 60 RNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDN---NVNGTLRLISAMRAANV 116 + AL+ +++ D D V+H A S + P ++Y++ N G ++ A + NV Sbjct: 76 ADHALVNQLIGDLQPDAVVHTAA------SYKDPDDWYNDTLTNCVGGSNVVQAAKKNNV 129 Query: 117 KNFIFSSSATVYGDQP-KIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALL 175 F++ +A YG +P + P P S Y SK E L Sbjct: 130 GRFVYFQTALCYGVKPIQQPVRLDHPRNPANSSYAISKSANEDYLE-----YSGLDFVTF 184 Query: 176 RYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIH 235 R N VG P+ + L + +++ G++ + RD++ Sbjct: 185 RLANVVG----------PRNVSGPLPIFFQRLSEGKKCFVT-----------KARRDFVF 223 Query: 236 VMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREG- 294 V DLA V A++ + G Y+ +G ++ ++ +A +A P R G Sbjct: 224 VKDLARATVRAVDGV----GHGAYHFSSGTDVAIKELYDAVVEAMALPSYPEPEIRELGP 279 Query: 295 -DLPAYWADASKADREL 310 D P+ D S+ ++ Sbjct: 280 DDAPSILLDPSRTIQDF 296 >2PK3-A nrPDB Length = 321 Score = 65.9 bits (159), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 75/331 (22%), Positives = 133/331 (40%), Gaps = 35/331 (10%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 MR L+TG +G++G + L + +V + + LP +E + DI Sbjct: 13 MRALITGVAGFVGKYLANHLTEQNVEVF---GTSRNNEAKLPNVE--------MISLDIM 61 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120 + + +++ D D + H A +V +S + NV GTL ++ A+R +N+ I Sbjct: 62 DSQRVKKVISDIKPDYIFHLAAKSSVKDSWLNKKGTFSTNVFGTLHVLDAVRDSNLDCRI 121 Query: 121 FS-SSATVYG-DQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYF 178 + S+ YG P+ V P SPYG SK V + KA I R F Sbjct: 122 LTIGSSEEYGMILPEESPVSEENQLRPMSPYGVSKASVGMLARQYVKAY-GMDIIHTRTF 180 Query: 179 NPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMD 238 N +G P +G + + I + + +++ + GN D T VRD + Sbjct: 181 NHIG--PGQSLG----FVTQDFAKQIVDIEMEKQEPIIKVGNLEAVRDFTDVRDIVQAYW 234 Query: 239 LADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAP--RREGDL 296 L + K G +YN+ +G+G + DV++ ++ P R ++ Sbjct: 235 LLSQY--------GKTG-DVYNVCSGIGTRIQDVLDLLLAMANVKIDTELNPLQLRPSEV 285 Query: 297 PAYWADASKADRELNWR----VTRTLDEMAQ 323 P + W+ + ++L E+ Q Sbjct: 286 PTLIGSNKRLKDSTGWKPRIPLEKSLFEILQ 316 >1OC2-A nrPDB Length = 348 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 90/345 (26%), Positives = 139/345 (40%), Gaps = 45/345 (13%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGH---DVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDI 59 ++VTGG+G+IGS+ V + N H V +LD L + +E + G V GDI Sbjct: 7 IIVTGGAGFIGSN-FVHYVYNNHPDVHVTVLDKLTYAGNKA--NLEAILGDRVELVVGDI 63 Query: 60 RNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNF 119 + L+ ++ D ++H+A S+ P + N GT L+ A R +++ F Sbjct: 64 ADAELVDKLA--AKADAIVHYAAESHNDNSLNDPSPFIHTNFIGTYTLLEAARKYDIR-F 120 Query: 120 IFSSSATVYGDQPKIPYV--------ESFPTGT---PQSPYGKSKLMVEQILTDLQKAQP 168 S+ VYGD P + E F T P SPY +K + I+ Sbjct: 121 HHVSTDEVYGDLPLREDLPGHGEGPGEKFTAETNYNPSSPYSSTKAASDLIVK------- 173 Query: 169 DWSIALLRYFNPVGAHPSGDMGEDP-QGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDG 227 A +R F + P Q I + I + G + L +G +G Sbjct: 174 ----AWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILAGIKPKL--YG------EG 221 Query: 228 TGVRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVN-Y 286 VRD+IH D + G + K + G Y +GA + +V+ + G+P + Y Sbjct: 222 KNVRDWIHTNDHSTGVWAILTK--GRMG-ETYLIGADGEKNNKEVLELILEKMGQPKDAY 278 Query: 287 HFAPRREGDLPAYWADASKADRELNWRVTRT-LDEMAQDTWHWQS 330 R G Y DASK EL W T E ++T W + Sbjct: 279 DHVTDRAGHDLRYAIDASKLRDELGWTPQFTDFSEGLEETIQWYT 323 >3SXP-A nrPDB Length = 362 Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 79/288 (27%), Positives = 131/288 (45%), Gaps = 36/288 (12%) Query: 3 VLVTGGSGYIGSHTCVQLLQN--GHDVIILDN------LCNSKRSVLPVIERLGGKHPTF 54 +L+TGG+G++GS+ +N V++LD N++ S L + L G Sbjct: 13 ILITGGAGFVGSNLAFHFQENHPKAKVVVLDKFRSNTLFSNNRPSSLGHFKNLIGFKGEV 72 Query: 55 VEGDIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEY-YDNNVNGTLRLISAMRA 113 + DI N + + H D + H A AV ++ E N L L+ R+ Sbjct: 73 IAADINNPLDLRRLEKLH-FDYLFHQA---AVSDTTMLNQELVMKTNYQAFLNLLEIARS 128 Query: 114 ANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIA 173 K I++SSA VYG+ K P V +P++ YG SKL +++ + L + + + Sbjct: 129 KKAK-VIYASSAGVYGN-TKAPNVVG-KNESPENVYGFSKLCMDEFV--LSHSNDNVQVG 183 Query: 174 LLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDY 233 LRYFN G P E + + Q+A+G ++A F E G +RD+ Sbjct: 184 -LRYFNVYG--PREFYKEKTASM-------VLQLALG---AMA-FKEVKLFEFGEQLRDF 229 Query: 234 IHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACG 281 +++ D+ +V AM+ A K GV YN+G S ++V+ + G Sbjct: 230 VYIEDVIQANVKAMK--AQKSGV--YNVGYSQARSYNEIVSILKEHLG 273 >6GPK-A nrPDB Length = 373 Score = 63.9 bits (154), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 83/352 (23%), Positives = 152/352 (43%), Gaps = 46/352 (13%) Query: 4 LVTGGSGYIGSHTCVQLLQNG---HDVIILDNLCNSKRSVLPVIERLGGKHPTFVEG--- 57 L+TG +G GS+ LL+ G H ++ + N+ R IE L +EG Sbjct: 28 LITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGR-----IEHLYKNPQAHIEGNMK 82 Query: 58 ----DIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNG--TLRLISAM 111 D+ + + +I+++ + + V + L Y +V+G TLRL+ A+ Sbjct: 83 LHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHV--KISFDLAEYTADVDGVGTLRLLDAV 140 Query: 112 RAANVKN---FIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQP 168 + + N F +S++ +YG +IP E+ P P+SPYG +KL I+ + ++A Sbjct: 141 KTCGLINSVKFYQASTSQLYGKVQEIPQKETTPF-YPRSPYGAAKLYAYWIVVNFREAYN 199 Query: 169 DWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGT 228 +++ + FN H S G + + + +A++ +G+ + ++ GN D Sbjct: 200 LFAVNGI-LFN----HESPRRGANF--VTRKISRSVAKIYLGQLECFSL-GNLDAKRDWG 251 Query: 229 GVRDYIHVMDL------------ADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAF 276 +DY+ M L A G V ++ + K +HI G + +V Sbjct: 252 HAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEV--GR 309 Query: 277 SKACGKP-VNYHFAPRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWH 327 K GK V R ++ D +KA ++LNW+ DE+ ++ H Sbjct: 310 CKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVH 361 >1DB3-A nrPDB Length = 372 Score = 62.8 bits (151), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 89/349 (25%), Positives = 150/349 (42%), Gaps = 37/349 (10%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNS--KRSVLPVIERLGGKHPTFV--EGDI 59 L+TG +G GS+ LL+ G++V + +S V + + +P F GD+ Sbjct: 5 LITGVTGQDGSYLAEFLLEKGYEVHGIKRRASSFNTERVDHIYQDPHTCNPKFHLHYGDL 64 Query: 60 RNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKN- 118 + + +T IL + D V + + V S + P D + GTLRL+ A+R ++ Sbjct: 65 SDTSNLTRILREVQPDEVYNLGAMSHVAVSFESPEYTADVDAMGTLRLLEAIRFLGLEKK 124 Query: 119 --FIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLR 176 F +S++ +YG +IP E+ P P+SPY +KL I + +++ ++ + Sbjct: 125 TRFYQASTSELYGLVQEIPQKETTPF-YPRSPYAVAKLYAYWITVNYRESYGMYACNGI- 182 Query: 177 YFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHV 236 FN H S GE + + IA +A G L + GN D +DY+ + Sbjct: 183 LFN----HESPRRGE--TFVTRKITRAIANIAQGLESCLYL-GNMDSLRDWGHAKDYVKM 235 Query: 237 ------MDLADGHVVA----------MEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKAC 280 + + V+A +E A + G+ + G GV + V A Sbjct: 236 QWMMLQQEQPEDFVIATGVQYSVRQFVEMAAAQLGIKLRFEGTGVEEKGIVVSVTGHDAP 295 Query: 281 G-KPVNYHFA--PR--REGDLPAYWADASKADRELNWRVTRTLDEMAQD 324 G KP + A PR R ++ D +KA +L W+ TL EM + Sbjct: 296 GVKPGDVIIAVDPRYFRPAEVETLLGDPTKAHEKLGWKPEITLREMVSE 344 >4EJ0-A nrPDB Length = 342 Score = 60.8 bits (146), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 75/294 (25%), Positives = 120/294 (40%), Gaps = 39/294 (13%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVII-LDNLCNSKRSVLPVIERLGGKHPTFVEGDI 59 M ++VTG +G+IG++ L + G II +DNL + K V+ +I Sbjct: 13 MTLIVTGAAGFIGANLVKALNERGETRIIAVDNLTRAD------------KFKNLVDCEI 60 Query: 60 RNEALMTEILHDHA------IDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRA 113 + TE + A + V H E+ + + DNN + ++ A A Sbjct: 61 DDYLDKTEFVERFARGDFGKVRAVFHEGACSDTMETDGRYM--MDNNFRYSRAVLDACLA 118 Query: 114 ANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIA 173 + F+++SSA +YG + +VE P + YG SK + +Q++ + IA Sbjct: 119 QGAQ-FLYASSAAIYGGSSR--FVEEREVEAPLNVYGYSKFLFDQVIRRVMPGAKS-QIA 174 Query: 174 LLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDY 233 RYFN G S G +N + A+ V +FG G RD+ Sbjct: 175 GFRYFNVYGPRES-HKGRMASVAFHNFNQFRAEGKV------KLFGEYSGYGPGEQTRDF 227 Query: 234 IHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLD----VVNAFSKACGKP 283 + V D+A ++ + K G I+NLG G D VVN G+P Sbjct: 228 VSVEDVAKVNLYFFDH-PEKSG--IFNLGTGRAQPFNDIAATVVNTLRALEGQP 278 >3M2P-A nrPDB Length = 311 Score = 60.1 bits (144), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 72/315 (22%), Positives = 132/315 (41%), Gaps = 44/315 (13%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 +++ VTGG+G++G + + +G+ IIL RS+ G K E + Sbjct: 3 LKIAVTGGTGFLGQYVVESIKNDGNTPIIL------TRSI-------GNKAINDYEYRVS 49 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120 + L I + +D V+H A + S K E++DN + T L A N+ N + Sbjct: 50 DYTLEDLINQLNDVDAVVHLAATRG---SQGKISEFHDNEI-LTQNLYDACYENNISNIV 105 Query: 121 FSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNP 180 ++S+ + Y D+ +P+ E P YG SKL E I ++ + I LR+ + Sbjct: 106 YASTISAYSDETSLPWNEK-ELPLPDLMYGVSKLACEHI-GNIYSRKKGLCIKNLRFAHL 163 Query: 181 VGAHPSGDMGEDPQGIPNNLM--PYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMD 238 G + NN M + Q G + +L + R++++ D Sbjct: 164 YGFNE-----------KNNYMINRFFRQAFHGEQLTLH--------ANSVAKREFLYAKD 204 Query: 239 LADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFA-PRREGDLP 297 A + A+++ + +N+G+G + +V N + A G N P + Sbjct: 205 AAKSVIYALKQ---EKVSGTFNIGSGDALTNYEVANTINNAFGNKDNLLVKNPNANEGIH 261 Query: 298 AYWADASKADRELNW 312 + + D+SKA L++ Sbjct: 262 SSYMDSSKAKELLDF 276 >2Z95-A nrPDB Length = 345 Score = 59.3 bits (142), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 81/343 (23%), Positives = 145/343 (42%), Gaps = 40/343 (11%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPT-FVEGDIR 60 R L+TG G G++ LL+ G++V D S ++ LG ++ + D+ Sbjct: 5 RALITGIRGQDGAYLAKLLLEKGYEVYGADRRSGEFASWR--LKELGIENDVKIIHMDLL 62 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANV-KNF 119 + + + D V + A VG S ++P+ + + G LR++ A+R F Sbjct: 63 EFSNIIRTIEKVQPDEVYNLAAQSFVGVSFEQPILTAEVDAIGVLRILEALRTVKPDTKF 122 Query: 120 IFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFN 179 +S++ ++G +IP E P P+SPY +KL I + ++A ++ + + FN Sbjct: 123 YQASTSEMFGKVQEIPQTEKTPF-YPRSPYAVAKLFGHWITVNYREAYNMFACSGI-LFN 180 Query: 180 PVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDL 239 H S G + + + +A++ G +D L + GN D +Y+ M L Sbjct: 181 ----HESPLRG--IEFVTRKITYSLARIKYGLQDKL-VLGNLNAKRDWGYAPEYVEAMWL 233 Query: 240 A------DGHVVA----------MEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGK- 282 D +V+A +EK A G I +G G+ +D + GK Sbjct: 234 MMQQPEPDDYVIATGETHTVREFVEKAAKIAGFDIEWVGEGINEKGID------RNTGKV 287 Query: 283 --PVNYHFAPRREGDLPAYWADASKADRELNWRVTRTLDEMAQ 323 V+ F E D+ + KA ++L W+ T DE+ + Sbjct: 288 IVEVSEEFFRPAEVDILV--GNPEKAMKKLGWKPRTTFDELVE 328 >5UZH-A nrPDB Length = 345 Score = 54.7 bits (130), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 65/245 (26%), Positives = 115/245 (46%), Gaps = 20/245 (8%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDV--IILDNLCNSKRSVLPVIERLGGKHPTF--VEGDI 59 L+TG +G GS+ LL+ G+ V II + + V + + + F + GD+ Sbjct: 5 LITGITGQDGSYLAEFLLEKGYMVYGIIRRSSSFNTGRVEHLYKDIHITKAKFKLLYGDL 64 Query: 60 RNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVN--GTLRLISAMRAANVK 117 + + I+ D + + A V S + P Y NV+ GTLRL+ A+RA ++ Sbjct: 65 TDTGNLISIIAKIKPDEIYNLAAQSHVKVSFEMP--EYTANVDGIGTLRLLEAIRACGLE 122 Query: 118 ---NFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIAL 174 F +S++ +YG ++P E+ P P+SPY +KL I+ + ++A +++ Sbjct: 123 KKTKFYQASTSELYGLVQEVPQKETTPF-YPRSPYACAKLYSYWIVVNYREAYNMFALNG 181 Query: 175 LRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYI 234 + FN H S G P + + +A++ +G +D L + GN D +DY+ Sbjct: 182 I-LFN----HESIRRG--PTFVTRKITMAVARIKLGLQDCLYL-GNLDAERDWGHAKDYV 233 Query: 235 HVMDL 239 M L Sbjct: 234 EAMWL 238 >1RKX-A nrPDB Length = 357 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 78/326 (23%), Positives = 129/326 (39%), Gaps = 35/326 (10%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 RV VTG +G+ G + L G V + S+ G GDIR+ Sbjct: 11 RVFVTGHTGFKGGWLSLWLQTMGATVKGYSLTAPTVPSLFETARVADGMQSEI--GDIRD 68 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMR-AANVKNFI 120 + + E + + + V H A V S +P+E Y NV GT+ L+ A+R VK + Sbjct: 69 QNKLLESIREFQPEIVFHMAAQPLVRLSYSEPVETYSTNVMGTVYLLEAIRHVGGVKAVV 128 Query: 121 FSSSATVYGDQPKI-PYVESFPTGTPQSPYGKSKLMVEQILTDLQKA--------QPDWS 171 +S Y ++ I Y E+ G PY SK E + + + + Q + Sbjct: 129 NITSDKCYDNKEWIWGYRENEAMGG-YDPYSNSKGCAELVTSSYRNSFFNPANYGQHGTA 187 Query: 172 IALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVR 231 +A +R N +G GD D + +P+ L + V R+ AI R Sbjct: 188 VATVRAGNVIGG---GDWALD-RIVPDILRAFEQSQPVIIRNPHAI-------------R 230 Query: 232 DYIHVMDLADGHVVAMEKLANKPGVHI--YNLGAGVGNS--VLDVVNAFSKACGKPVNYH 287 + HV++ G+++ +KL + +N G ++ V ++V K G+ ++ Sbjct: 231 PWQHVLEPLSGYLLLAQKLYTDGAEYAEGWNFGPNDADATPVKNIVEQMVKYWGEGASWQ 290 Query: 288 FAPRREGDLPAYWA-DASKADRELNW 312 Y D SKA +L W Sbjct: 291 LDGNAHPHEAHYLKLDCSKAKMQLGW 316 >1WVG-A nrPDB Length = 359 Score = 52.8 bits (125), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 64/261 (24%), Positives = 113/261 (43%), Gaps = 34/261 (13%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIE--RLGGKHPTFVEGDI 59 RV VTG +G+ GS + L + G I+ +V + E RL + + GDI Sbjct: 11 RVFVTGHTGFKGSWLSLWLTEMG---AIVKGYALDAPTVPSLFEIVRLNDLMESHI-GDI 66 Query: 60 RNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMR-AANVKN 118 R+ + + + + V H A V S ++P++ Y NV GT+ L+ ++ N+K Sbjct: 67 RDFEKLRSSIAEFKPEIVFHMAAQPLVRLSYEQPIKTYSTNVMGTVHLLETVKQVGNIKA 126 Query: 119 FIFSSSATVYGDQPKI-PYVESFPTGTPQSPYGKSKLMVEQILTDLQKA--------QPD 169 + +S Y ++ + Y E+ P G PY SK E + + + + Q Sbjct: 127 VVNITSDKCYDNREWVWGYRENEPMGG-YDPYSNSKGCAELVASAFRNSFFNPANYEQHG 185 Query: 170 WSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTG 229 +A +R N +G GD +D + IP+ L + + I N Y Sbjct: 186 VGLASVRAGNVIGG---GDWAKD-RLIPDILRSF-------ENNQQVIIRNPY------S 228 Query: 230 VRDYIHVMDLADGHVVAMEKL 250 +R + HV++ G++V ++L Sbjct: 229 IRPWQHVLEPLSGYIVVAQRL 249 >1EQ2-A nrPDB Length = 310 Score = 52.0 bits (123), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 68/283 (24%), Positives = 123/283 (43%), Gaps = 45/283 (15%) Query: 3 VLVTGGSGYIGSHTCVQLLQNG-HDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 ++VTGG+G+IGS+ L G D++++DNL + G K V+ +I + Sbjct: 2 IIVTGGAGFIGSNIVKALNDKGITDILVVDNLKD------------GTKFVNLVDLNIAD 49 Query: 62 ----EALMTEILHDHA---IDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAA 114 E + +I+ ++ + H + E K + DNN + L+ Sbjct: 50 YMDKEDFLIQIMAGEEFGDVEAIFHEGACSSTTEWDGKYM--MDNNYQYSKELLHYCLER 107 Query: 115 NVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIAL 174 + F+++SSA YG + ++ES P + YG SK + ++ + + + + I Sbjct: 108 EIP-FLYASSAATYGGRTS-DFIESREYEKPLNVYGYSKFLFDEYVRQIL-PEANSQIVG 164 Query: 175 LRYFNPVGAHPSGDMGEDPQGIPNNLMPYI-AQVAVGRRDSLAIFGNDYPTEDGTGVRDY 233 RYFN G E +G ++ ++ Q+ G L ++ RD+ Sbjct: 165 FRYFNVYGPR------EGHKGSMASVAFHLNTQLNNGESPKLFEGSENFK-------RDF 211 Query: 234 IHVMDLADGHVVAMEKLANKPGVH-IYNLGAGVGNSVLDVVNA 275 ++V D+AD ++ +E GV I+NLG G S V +A Sbjct: 212 VYVGDVADVNLWFLEN-----GVSGIFNLGTGRAESFQAVADA 249 >2X86-A nrPDB Length = 357 Score = 50.8 bits (120), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 67/283 (23%), Positives = 123/283 (43%), Gaps = 45/283 (15%) Query: 3 VLVTGGSGYIGSHTCVQLLQNG-HDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 ++VTGG+G+IGS+ L G D++++DNL + G K V+ +I + Sbjct: 49 IIVTGGAGFIGSNIVKALNDKGITDILVVDNLKD------------GTKFVNLVDLNIAD 96 Query: 62 ----EALMTEILHDHA---IDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAA 114 E + +I+ ++ + H + E K + DNN + L+ Sbjct: 97 YMDKEDFLIQIMAGEEFGDVEAIFHEGACSSTTEWDGKYM--MDNNYQYSKELLHYCLER 154 Query: 115 NVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIAL 174 + F+++SSA YG + ++ES P + +G SK + ++ + + + + I Sbjct: 155 EIP-FLYASSAATYGGRTS-DFIESREYEKPLNVFGYSKFLFDEYVRQIL-PEANSQIVG 211 Query: 175 LRYFNPVGAHPSGDMGEDPQGIPNNLMPYI-AQVAVGRRDSLAIFGNDYPTEDGTGVRDY 233 RYFN G E +G ++ ++ Q+ G L ++ RD+ Sbjct: 212 FRYFNVYGPR------EGHKGSMASVAFHLNTQLNNGESPKLFEGSENFK-------RDF 258 Query: 234 IHVMDLADGHVVAMEKLANKPGVH-IYNLGAGVGNSVLDVVNA 275 ++V D+AD ++ +E GV I+NLG G S V +A Sbjct: 259 VYVGDVADVNLWFLEN-----GVSGIFNLGTGRAESFQAVADA 296 >4WKG-A nrPDB Length = 660 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 50/188 (26%), Positives = 81/188 (43%), Gaps = 16/188 (8%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGH-DVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 RVL+ G +G+IG+H +LL+ H +V LD ++ + L H FVEGDI Sbjct: 317 RVLILGVNGFIGNHLTERLLREDHYEVYGLDIGSDA------ISRFLNHPHFHFVEGDIS 370 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120 + E H D V+ + E + PL ++ + LR+I K I Sbjct: 371 IHSEWIE-YHVKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLRIIRYC-VKYRKRII 428 Query: 121 FSSSATVYGDQPKIPYVESF------PTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIAL 174 F S++ VYG + E P P+ Y SK ++++++ + + L Sbjct: 429 FPSTSEVYGMCSDKYFDEDHSNLIVGPVNKPRWIYSVSKQLLDRVIWAYGEKE-GLQFTL 487 Query: 175 LRYFNPVG 182 R FN +G Sbjct: 488 FRPFNWMG 495 >2C54-A nrPDB Length = 379 Score = 49.3 bits (116), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 74/337 (21%), Positives = 132/337 (39%), Gaps = 38/337 (11%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 +++ +TG G+I SH +L GH VI D N + E + V+ + Sbjct: 30 LKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEH-----MTEDMFCDEFHLVDLRVM 84 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120 L DH + G+ + +S + Y NN + +I A R +K F Sbjct: 85 ENCLKVTEGVDHVFNLAADMGGMGFI-QSNHSVIMY--NNTMISFNMIEAARINGIKRFF 141 Query: 121 FSSSATVYGDQPKIPYV-------ESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIA 173 ++SSA +Y + ++ +++P PQ YG +L E++ K D+ I Sbjct: 142 YASSACIYPEFKQLETTNVSLKESDAWP-AEPQDAYGLERLATEELCKHYNK---DFGIE 197 Query: 174 --LLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVR 231 + R+ N G P G + P + A D ++G DG R Sbjct: 198 CRIGRFHNIYG--PFGTWKGGREKAP----AAFCRKAQTSTDRFEMWG------DGLQTR 245 Query: 232 DYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPR 291 + + + +G V+ + K + V+I + N + ++V +F + K + H P Sbjct: 246 SFTFIDECVEG-VLRLTKSDFREPVNIGSDEMVSMNEMAEMVLSFEE---KKLPIHHIPG 301 Query: 292 REGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHW 328 EG + +D + +L W L E + T+ W Sbjct: 302 PEG-VRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFW 337 >1ZZE-A nrPDB Length = 342 Score = 46.2 bits (108), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 48/141 (34%), Positives = 66/141 (46%), Gaps = 15/141 (10%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 VLVTG +G++ SH QLL++G+ V S + + +R K+P E Sbjct: 14 VLVTGANGFVASHVVEQLLEHGYKV---RGTARSASKLANLQKRWDAKYPGRFE-----T 65 Query: 63 ALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVN----GTLRLISAMRAA-NVK 117 A++ ++L A D VI A A SV YD V GTL + A A +VK Sbjct: 66 AVVEDMLKQGAYDEVIKGAAGVAHIASVVSFSNKYDEVVTPAIGGTLNALRAAAATPSVK 125 Query: 118 NFIFSSSATVYGDQPKIPYVE 138 F+ +SS TV PK P VE Sbjct: 126 RFVLTSS-TVSALIPK-PNVE 144 >6GCS-E nrPDB Length = 375 Score = 44.7 bits (104), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 43/160 (26%), Positives = 73/160 (45%), Gaps = 25/160 (15%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN-EA 63 V G +G++GS+ +L ++G V++ +KR L V LG + F+E D+RN E+ Sbjct: 58 VFGANGFLGSYLTAKLAKHGTTVVVPYREEMAKRH-LKVTGDLGVVN--FLEMDLRNLES 114 Query: 64 LMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFSS 123 + + H D V++ G E K YYD +V G R+ A++ N+ +I S Sbjct: 115 IDEAVRHS---DIVVNLIG----REYETKNFNYYDVHVEGARRIAEAVKKHNIARYIHVS 167 Query: 124 SATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDL 163 + D P S + +K + EQ+ D+ Sbjct: 168 AFNAEIDSP--------------SEFNHTKGLGEQVTKDI 193 >2GN9-A nrPDB Length = 344 Score = 40.0 bits (92), Expect = 0.001, Method: Compositional matrix adjust. Identities = 48/190 (25%), Positives = 78/190 (41%), Gaps = 28/190 (14%) Query: 3 VLVTGGSGYIGSHTCVQLL--QNGHDVIIL--DNLCNSKRSVLPVIERLGGKHPTFVEGD 58 +L+TGG+G G ++L N +I+ D L S+ ++ F GD Sbjct: 24 ILITGGTGSFGKCFVRKVLDTTNAKKIIVYSRDELKQSEMAM-----EFNDPRMRFFIGD 78 Query: 59 IRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKN 118 +R+ + L +D IH A LK V + PLE N+ G +I+A +KN Sbjct: 79 VRDLERLNYALE--GVDICIHAAALKHVPIAEYNPLECIKTNIMGASNVINAC----LKN 132 Query: 119 FIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQ--KAQPDWSIALLR 176 I S + D+ P + YG +KL +++ K +++R Sbjct: 133 AI-SQVIALSTDK----------AANPINLYGATKLCSDKLFVSANNFKGSSQTQFSVVR 181 Query: 177 YFNPVGAHPS 186 Y N VG+ S Sbjct: 182 YGNVVGSRGS 191 >4QUK-A nrPDB Length = 319 Score = 38.9 bits (89), Expect = 0.003, Method: Compositional matrix adjust. Identities = 63/266 (23%), Positives = 106/266 (39%), Gaps = 35/266 (13%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 V VTG SGYI S LL G+ V N + V +++ G K R + Sbjct: 3 VCVTGASGYIASWLVRLLLHRGYTVKATVRDPNDPKKVDHLVKLDGAKE--------RLQ 54 Query: 63 ALMTEILHDHAIDTVIH-----FAGLKAVGESVQKP-LEYYDNNVNGTLRLI-SAMRAAN 115 +L + A D+V+ F V+ P E D + GTL ++ S ++ + Sbjct: 55 LFKANLLEEGAFDSVVQGCHGVFHTASPFYHDVKDPQAELIDPALKGTLNVLNSCAKSPS 114 Query: 116 VKNFIFSSS--ATVYGDQPKIPYVESFPTGTPQSPY-GKSKLMVEQILTDLQKAQPDWSI 172 +K + +SS A Y +P+ P V T + + KS L +++ + W Sbjct: 115 LKRVVLTSSIAAVAYNGKPRTPDVVVDETWFTDADFCAKSNLW--YVVSATLAEEAAWKF 172 Query: 173 ALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRD-SLAIFGNDYPTEDGTGVR 231 + V +P+ +G Q + N I + G + A FG Sbjct: 173 VKENNIDMVTINPAMVIGPLLQPVLNTSAAAILNLINGAQTFPNASFG------------ 220 Query: 232 DYIHVMDLADGHVVAMEKLANKPGVH 257 +++V D+A+ H++A E A+ G H Sbjct: 221 -WVNVKDVANAHILAYEN-ASASGRH 244 >1GFS-A nrPDB Length = 321 Score = 38.5 bits (88), Expect = 0.004, Method: Compositional matrix adjust. Identities = 74/342 (21%), Positives = 128/342 (37%), Gaps = 50/342 (14%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 RV + G G +GS QL Q G ++L T E ++ + Sbjct: 5 RVFIAGHRGMVGSAIRRQLEQRGDVELVLR---------------------TRDELNLLD 43 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQK--PLEYYDNNVNGTLRLISAMRAANVKNF 119 + + ID V + A K G P ++ N+ +I A +V Sbjct: 44 SRAVHDFFASERIDQV-YLAAAKVGGIVANNTYPADFIYQNMMIESNIIHAAHQNDVNKL 102 Query: 120 IFSSSATVYGDQPKIPYVES-FPTGTPQ---SPYGKSKLMVEQILT--DLQKAQPDWSIA 173 +F S+ +Y K P ES GT + PY +K+ ++ + Q + S+ Sbjct: 103 LFLGSSCIYPKLAKQPMAESELLQGTLEPTNEPYAIAKIAGIKLCESYNRQYGRDYRSVM 162 Query: 174 LLRYFNPV-GAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRD 232 + P HPS + IP L + A D + ++G+ GT +R+ Sbjct: 163 PTNLYGPHDNFHPS-----NSHVIPALLRRFHEATAQNAPD-VVVWGS------GTPMRE 210 Query: 233 YIHVMDLADGHVVAMEK-----LAN-KPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNY 286 ++HV D+A + ME L N +P + N+G GV ++ ++ +K G Sbjct: 211 FLHVDDMAAASIHVMELAHEVWLENTQPMLSHINVGTGVDCTIRELAQTIAKVVGYKGRV 270 Query: 287 HFAPRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHW 328 F + P D ++ +L W +L+ T+ W Sbjct: 271 VFDASKPDGTPRKLLDVTRL-HQLGWYHEISLEAGLASTYQW 311 >2QYS-A nrPDB Length = 318 Score = 38.1 bits (87), Expect = 0.005, Method: Compositional matrix adjust. Identities = 22/77 (28%), Positives = 40/77 (51%), Gaps = 5/77 (6%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 ++L+ GG+GYIG+H L+ GH + +SK ++L + LG V+G++ Sbjct: 13 KILIFGGTGYIGNHMVKGSLKLGHPTYVFTRPNSSKTTLLDEFQSLGA---IIVKGELDE 69 Query: 62 EALMTEILHDHAIDTVI 78 + E++ +D VI Sbjct: 70 HEKLVELMKK--VDVVI 84 >4G5H-A nrPDB Length = 363 Score = 37.7 bits (86), Expect = 0.006, Method: Compositional matrix adjust. Identities = 39/158 (24%), Positives = 66/158 (41%), Gaps = 19/158 (12%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 +L+TGG+G G+ + L + I + + K+ + ++ F GD+R+ Sbjct: 28 LLITGGTGSFGNAVMKRFLDSNIKEIRIFSRDEKKQD--DIRKKYNNSKLKFYIGDVRDS 85 Query: 63 ALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFS 122 + + D +D V H A LK V P+E N+ GT ++ + NVK I Sbjct: 86 QSVETAMRD--VDYVFHAAALKQVPSCEFFPVEAVKTNIIGTENVLQSAIHQNVKKVICL 143 Query: 123 SSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQIL 160 S+ K Y P + G SK M+E++ Sbjct: 144 ST-------DKAAY--------PINAMGISKAMMEKVF 166 >5B6K-A nrPDB Length = 366 Score = 37.7 bits (86), Expect = 0.007, Method: Compositional matrix adjust. Identities = 74/301 (24%), Positives = 108/301 (35%), Gaps = 32/301 (10%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 V V+G +G+I H QLL + VI + VI + GG + DI + Sbjct: 24 VFVSGATGFIAQHVVRQLLDQNYKVIGSVRSAEKGDHLKNVIFK-GGDFNYEIVKDISDP 82 Query: 63 ALMTEILHDHA--IDTVIHFAG-LKAVGESVQKPLEY-YDNNVNGTLRLISAMRAANVKN 118 + H I V+H A ++K L N G L I A V+ Sbjct: 83 TAFDHVFEKHGKDIKVVLHTASPFHFNTTDIEKDLLIPAVNGTKGILESIKKYAAQTVER 142 Query: 119 FIFSSS-----ATV----YGDQPKIPYVESFPTGT-------PQSPYGKSKLMVEQILTD 162 + +SS +TV D K ES+ T P Y SK E+ D Sbjct: 143 VVVTSSFAANTSTVDMFYAKDSSKTITEESWNQDTWESCQSDPIRGYCGSKKFAEKAAWD 202 Query: 163 LQKAQPDWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDY 222 A D L NPV + E + I N I +SL D Sbjct: 203 FYNANKDSVKFKLSIINPVYVFGPQNYVEPGKKILNTSSEVI--------NSLVHLKKDD 254 Query: 223 PTEDGTGVRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNA-FSKACG 281 P + G +I V D+A H++A +K + + G ++LD++N F + G Sbjct: 255 PLPEFAG--GHIDVRDVAKAHILAFQKDELIEQRLMLHAGLFTTQTLLDIINEQFPELKG 312 Query: 282 K 282 K Sbjct: 313 K 313 >5U9C-A nrPDB Length = 292 Score = 37.7 bits (86), Expect = 0.008, Method: Compositional matrix adjust. Identities = 37/157 (23%), Positives = 69/157 (43%), Gaps = 24/157 (15%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 ++L+TGG+G +G++ L ++VI+ + N+ +P Sbjct: 7 KILITGGTGMLGAYVTSALKDTDYNVIVTER--NTLNLSVP------------------- 45 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIF 121 EA+ + I + D ++HFA V ++P N T ++ A + ++ Sbjct: 46 EAIFSYITAEKP-DVILHFAAETDVDLCEREPARAGIYNHLATEQIAQAAKFCGAW-LLY 103 Query: 122 SSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQ 158 SS+ V+G + K+ Y E P + YG+SKL+ E Sbjct: 104 LSSSNVFGGEGKLSYNE-LDIPLPMNYYGRSKLIGES 139 >4KTT-E nrPDB Length = 327 Score = 37.0 bits (84), Expect = 0.011, Method: Compositional matrix adjust. Identities = 39/153 (25%), Positives = 61/153 (39%), Gaps = 18/153 (11%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 RVLVTG +G +G + QN + C +R+ P F + ++ + Sbjct: 23 RVLVTGATGLLGRAVHKEFQQNNWHAV----GCGFRRA-----------RPKFEQVNLLD 67 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIF 121 + I+HD ++H A + +P NV+ + L A AA V F+ Sbjct: 68 SNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGNL--AKEAAAVGAFLI 125 Query: 122 SSSATVYGDQPKIPYVESFPTGTPQSPYGKSKL 154 S+ D PY E P + YGK+KL Sbjct: 126 YISSDYVFDGTNPPYREE-DIPAPLNLYGKTKL 157 >2P4H-X nrPDB Length = 322 Score = 36.6 bits (83), Expect = 0.016, Method: Compositional matrix adjust. Identities = 47/186 (25%), Positives = 75/186 (40%), Gaps = 36/186 (19%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPT--FVEGDI 59 RV VTGG+G++GS LL+NG+ V ++ + + L G F D+ Sbjct: 3 RVCVTGGTGFLGSWIIKSLLENGYSVNTTIRADPERKRDVSFLTNLPGASEKLHFFNADL 62 Query: 60 RNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYY-DNNVNGTLRLISA-MRAANVK 117 N + + H A + +V +P E V+G L ++ A + + VK Sbjct: 63 SNPDSFAAAIEGCV--GIFHTAS--PIDFAVSEPEEIVTKRTVDGALGILKACVNSKTVK 118 Query: 118 NFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWS-IALLR 176 FI++SS G+ S GK K +++ + DWS + LLR Sbjct: 119 RFIYTSS------------------GSAVSFNGKDKDVLD---------ESDWSDVDLLR 151 Query: 177 YFNPVG 182 P G Sbjct: 152 SVKPFG 157 >1VL0-A nrPDB Length = 292 Score = 36.2 bits (82), Expect = 0.022, Method: Compositional matrix adjust. Identities = 42/164 (25%), Positives = 67/164 (40%), Gaps = 26/164 (15%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEG-DI 59 M++L+TG +G +G QL +VI PT V+ DI Sbjct: 13 MKILITGANGQLGREIQKQLKGKNVEVI-----------------------PTDVQDLDI 49 Query: 60 RNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNF 119 N + + ++ + VI+ A AV + ++ Y N G L +A + + Sbjct: 50 TNVLAVNKFFNEKKPNVVINCAAHTAVDKCEEQYDLAYKINAIGPKNLAAAAYSVGAE-I 108 Query: 120 IFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDL 163 + S+ V+ + K P E F PQS YGK+KL E + L Sbjct: 109 VQISTDYVFDGEAKEPITE-FDEVNPQSAYGKTKLEGENFVKAL 151 >1QYC-A nrPDB Length = 308 Score = 35.8 bits (81), Expect = 0.025, Method: Compositional matrix adjust. Identities = 23/83 (27%), Positives = 37/83 (44%), Gaps = 4/83 (4%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIIL--DNLCNSKRSVLPVIERLGGKHPTFVEGDI 59 R+L+ G +GYIG H L GH +L ++ +S ++E V G I Sbjct: 6 RILLIGATGYIGRHVAKASLDLGHPTFLLVRESTASSNSEKAQLLESFKASGANIVHGSI 65 Query: 60 RNEALMTEILHDHAIDTVIHFAG 82 + A + E + + +D VI G Sbjct: 66 DDHASLVEAVKN--VDVVISTVG 86 >3RFT-A nrPDB Length = 267 Score = 35.0 bits (79), Expect = 0.040, Method: Compositional matrix adjust. Identities = 38/159 (23%), Positives = 64/159 (40%), Gaps = 18/159 (11%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 R+LVTG +G +G + L +++ L +L + G + V+ D+ + Sbjct: 5 RLLVTGAAGQLG-RVMRERLAPMAEILRLADLSPLDPA---------GPNEECVQCDLAD 54 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLE-YYDNNVNGTLRLISAMRAANVKNFI 120 + ++ D ++H G+ SV+KP E N+ G L A RA + Sbjct: 55 ANAVNAMVA--GCDGIVHLGGI-----SVEKPFEQILQGNIIGLYNLYEAARAHGQPRIV 107 Query: 121 FSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQI 159 F+SS G P+ + P YG SK E + Sbjct: 108 FASSNHTIGYYPQTERLGPDVPARPDGLYGVSKCFGENL 146 >4R1U-A nrPDB Length = 349 Score = 35.0 bits (79), Expect = 0.046, Method: Compositional matrix adjust. Identities = 40/134 (29%), Positives = 56/134 (41%), Gaps = 18/134 (13%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 V VTG G+I S LL+ G+ V R + E H +EG Sbjct: 30 VCVTGAGGFIASWLVKLLLERGYTV----------RGTVRNPEDPKNGHLKELEGARERL 79 Query: 63 AL-MTEILHDHAIDTVIHFAGLKAVGESVQ----KPLEYYDNNVNGTLRLISAMRAANVK 117 L ++L +I +V+H G V + P E + VNGT +I A A V+ Sbjct: 80 TLHKVDLLDLQSIQSVVH--GCHGVFHTASPVTDNPDEMLEPAVNGTKNVIIASAEAKVR 137 Query: 118 NFIFSSS-ATVYGD 130 +F+SS TVY D Sbjct: 138 RVVFTSSIGTVYMD 151 >4RHE-A nrPDB Length = 209 Score = 34.3 bits (77), Expect = 0.079, Method: Compositional matrix adjust. Identities = 33/131 (25%), Positives = 50/131 (38%), Gaps = 21/131 (16%) Query: 105 LRLISAMRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQ 164 +RLI + AAN + +I SSA +I P SP SK + E+ Sbjct: 26 MRLIECLIAANYQLYILCSSAG------RIVLDTEVGVKIPSSPDAASKFLTEKYQA--- 76 Query: 165 KAQPDWSIALLRYFNPVGAHPS------------GDMGEDPQGIPNNLMPYIAQVAVGRR 212 K Q ++F+PV + S G M G+ +NL+ A V + R Sbjct: 77 KDQQITVFGKEQWFSPVASGSSAPKQMVVCPCSTGTMAAICHGMSDNLIERAADVVIKER 136 Query: 213 DSLAIFGNDYP 223 L + + P Sbjct: 137 GQLILMVRETP 147 >2NNL-D nrPDB Length = 337 Score = 33.9 bits (76), Expect = 0.10, Method: Compositional matrix adjust. Identities = 44/145 (30%), Positives = 66/145 (45%), Gaps = 15/145 (10%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDV-IILDNLCNSKRSV----LPVIERLGGKHPTFVEG 57 V VTG SG+IGS ++LL+ G+ V + + N K+ LP E H T + Sbjct: 8 VCVTGASGFIGSWLVMRLLERGYTVRATVRDPTNVKKVKHLLDLPKAE----THLTLWKA 63 Query: 58 DIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAA-NV 116 D+ +E E + V H A ES E + G L ++ + AA V Sbjct: 64 DLADEGSFDEAI--KGCTGVFHVATPMDF-ESKDPENEVIKPTIEGMLGIMKSCAAAKTV 120 Query: 117 KNFIFSSSA-TVYGDQPKIP-YVES 139 + +F+SSA TV + ++P Y ES Sbjct: 121 RRLVFTSSAGTVNIQEHQLPVYDES 145 >1DIR-A nrPDB Length = 241 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 26/93 (27%), Positives = 46/93 (49%), Gaps = 4/93 (4%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 RVLV GG G +GS CVQ + + + ++ ++ + VI ++ +F E + Sbjct: 9 RVLVYGGRGALGSR-CVQAFRARNWWVASIDVVENEEASASVIVKM---TDSFTEQADQV 64 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPL 94 A + ++L D +D ++ AG A G + K L Sbjct: 65 TAEVGKLLGDQKVDAILCVAGGWAGGNAKSKSL 97 >3OIC-A nrPDB Length = 258 Score = 33.9 bits (76), Expect = 0.11, Method: Compositional matrix adjust. Identities = 19/50 (38%), Positives = 30/50 (60%), Gaps = 5/50 (10%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPV---IERLGGK 50 LVTG S +G ++L +NG++++I N SK++ L IE+LG K Sbjct: 8 LVTGSSRGVGKAAAIRLAENGYNIVI--NYARSKKAALETAEEIEKLGVK 55 >4R1T-A nrPDB Length = 337 Score = 33.5 bits (75), Expect = 0.13, Method: Compositional matrix adjust. Identities = 40/136 (29%), Positives = 60/136 (44%), Gaps = 12/136 (8%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVI-ILDNLCNSKRSVLPVIERLGGKHP-TFVEGDIR 60 V VTG G+I S LL+ G+ V + N + K L +E G K T + D+ Sbjct: 13 VCVTGAGGFIASWLVKILLEKGYTVRGTVRNPDDPKNGHLRELE--GAKERLTLCKADLL 70 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120 + + E ++ D V H A P + + V GT +I+A ANV+ + Sbjct: 71 DYQSLREAIN--GCDGVFHTAS-----PVTDDPEQMVEPAVIGTKNVINAAAEANVRRVV 123 Query: 121 FSSS-ATVYGDQPKIP 135 F+SS VY D + P Sbjct: 124 FTSSIGAVYMDPNRDP 139 >4PVC-A nrPDB Length = 342 Score = 32.7 bits (73), Expect = 0.23, Method: Compositional matrix adjust. Identities = 70/296 (23%), Positives = 107/296 (36%), Gaps = 38/296 (12%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTF---VEG 57 M V V+G +G+I H LL+ + VI S+ + E G +P F V Sbjct: 1 MSVFVSGANGFIAQHIVDLLLKEDYKVI---GSARSQEKAENLTEAFGN-NPKFSMEVVP 56 Query: 58 DIRNEALMTEILHDHA--IDTVIHFAG--LKAVGESVQKPLEYYDNNVNGTLRLISAMRA 113 DI + H I V+H A + +S + L N V G L I A Sbjct: 57 DISKLDAFDHVFQKHGKDIKIVLHTASPFCFDITDSERDLLIPAVNGVKGILHSIKKYAA 116 Query: 114 ANVKNFIFSSS-ATVY-----GDQPKIPYVESFPTGT-------PQSPYGKSKLMVEQIL 160 +V+ + +SS A V+ D+ ES+ T P + Y SK E+ Sbjct: 117 DSVERVVLTSSYAAVFDMAKENDKSLTFNEESWNPATWESCQSDPVNAYCGSKKFAEKAA 176 Query: 161 TDLQKAQPDWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVA-VGRRDSL-AIF 218 + + D L NPV +D + N + + + D + +F Sbjct: 177 WEFLEENRDSVKFELTAVNPVYVFGPQMFDKDVKKHLNTSCELVNSLMHLSPEDKIPELF 236 Query: 219 GNDYPTEDGTGVRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVN 274 G YI V D+A H+VA +K I + VLD++N Sbjct: 237 GG------------YIDVRDVAKAHLVAFQKRETIGQRLIVSEARFTMQDVLDILN 280 >3PXX-A nrPDB Length = 287 Score = 32.7 bits (73), Expect = 0.23, Method: Compositional matrix adjust. Identities = 33/127 (25%), Positives = 58/127 (45%), Gaps = 20/127 (15%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPV------------IERLGGK 50 VLVTGG+ G V+L + G D+I+ D + + + P+ +E+ G K Sbjct: 13 VLVTGGARGQGRSHAVKLAEEGADIILFDICHDIETNEYPLATSRDLEEAGLEVEKTGRK 72 Query: 51 HPTFVEGDIRNEALMTEILHDHA-----IDTVIHFAGLKAVGE--SVQKPLEYYDNNVNG 103 T E D+R+ A ++ L + +D V+ AG+ +G VQ + +D + G Sbjct: 73 AYT-AEVDVRDRAAVSRELANAVAEFGKLDVVVANAGICPLGAHLPVQAFADAFDVDFVG 131 Query: 104 TLRLISA 110 + + A Sbjct: 132 VINTVHA 138 >3WTC-A nrPDB Length = 262 Score = 32.7 bits (73), Expect = 0.25, Method: Compositional matrix adjust. Identities = 31/115 (26%), Positives = 50/115 (43%), Gaps = 20/115 (17%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEAL 64 VTG + IG ++L ++G DVI+LD ++ +E L G+ + DI N Sbjct: 13 VTGAAQGIGKAIALRLAKDGADVILLDVKQDTLAETAKEVEAL-GRRAVALTADISNRDQ 71 Query: 65 MTEILHDHA-----IDTVIHFAGLKAVGESVQKPL---------EYYDNNVNGTL 105 L D A +D +++ AG+ V KP+ + + NV G L Sbjct: 72 FRSTLADAAKTLGGLDIMVNNAGICQV-----KPILDIEPAEIEKIFSINVQGVL 121 >2QV3-A nrPDB Length = 457 Score = 32.0 bits (71), Expect = 0.36, Method: Compositional matrix adjust. Identities = 20/47 (42%), Positives = 25/47 (53%), Gaps = 4/47 (8%) Query: 128 YGDQPKIPYVE---SFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWS 171 Y D I VE F + TP++P+G SKLM LT Q A D+S Sbjct: 225 YFDARNIKNVEITRKFASSTPENPWGTSKLMFNN-LTLGQNAVMDYS 270 >4B4O-A nrPDB Length = 298 Score = 31.6 bits (70), Expect = 0.45, Method: Compositional matrix adjust. Identities = 14/32 (43%), Positives = 20/32 (62%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDN 32 MRVLV GG+G+IG+ L GH+V ++ Sbjct: 1 MRVLVGGGTGFIGTALTQLLNARGHEVTLVSR 32 >3WOH-A nrPDB Length = 251 Score = 31.6 bits (70), Expect = 0.57, Method: Compositional matrix adjust. Identities = 39/155 (25%), Positives = 68/155 (43%), Gaps = 24/155 (15%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIIL---DNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 LVTGGS +G ++L ++G V I+ D+ +S + IERLGG ++ D+ Sbjct: 15 LVTGGSRGLGRAMALRLARDGAAVAIVYVSDD--SSAKETQGEIERLGGTARSY-RCDVS 71 Query: 61 NEALMTEILHDHA-----IDTVIHFAGLKAVGESVQKPLEYYD----NNVNGTLRLISAM 111 + +T + +D +++ AG+ G + E YD N+ G I A Sbjct: 72 DAEQVTRCVKAVTADLGPVDILVNNAGIIRDGLAASIKDEDYDAVMNTNLKGAFLFIKAC 131 Query: 112 -------RAANVKNFIFSSSATVYGDQPKIPYVES 139 R+ ++ N SS + V+G + Y + Sbjct: 132 YFGFIRKRSGSIIN--ISSVSGVFGSAGQANYASA 164 >3SLK-A nrPDB Length = 795 Score = 31.2 bits (69), Expect = 0.61, Method: Compositional matrix adjust. Identities = 32/139 (23%), Positives = 63/139 (45%), Gaps = 13/139 (9%) Query: 3 VLVTGGSGYIGSHTCVQL-LQNG-HDVIILDNLCNSKRSVLPVIERLG--GKHPTFVEGD 58 VLVTGG+G +G+ L ++ G +++++ + ++ +L G + D Sbjct: 533 VLVTGGTGALGAEVARHLVIERGVRNLVLVSRRGPAASGAAELVAQLTAYGAEVSLQACD 592 Query: 59 IRNEALMTEILH----DHAIDTVIHFAGLKAVGESVQKPLEYYDN----NVNGTLRLISA 110 + + + ++L +H + V+H AG+ G S +E D V+G L+ Sbjct: 593 VADRETLAKVLASIPDEHPLTAVVHAAGVLDDGVSESLTVERLDQVLRPKVDGARNLLEL 652 Query: 111 MRAANVKNFIFSSSATVYG 129 + +V +FSS + V G Sbjct: 653 ID-PDVALVLFSSVSGVLG 670 >3R3S-A nrPDB Length = 294 Score = 31.2 bits (69), Expect = 0.68, Method: Compositional matrix adjust. Identities = 21/71 (29%), Positives = 32/71 (45%), Gaps = 3/71 (4%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVII--LDNLCNSKRSVLPVIERLGGKHPTFVEGDI 59 + LVTGG IG + + G DV I L + V +IE G K + GD+ Sbjct: 51 KALVTGGDSGIGRAAAIAYAREGADVAINYLPAEEEDAQQVKALIEECGRKA-VLLPGDL 109 Query: 60 RNEALMTEILH 70 +E+ ++H Sbjct: 110 SDESFARSLVH 120 >2Q2Q-A nrPDB Length = 255 Score = 30.8 bits (68), Expect = 0.76, Method: Compositional matrix adjust. Identities = 40/149 (26%), Positives = 62/149 (41%), Gaps = 15/149 (10%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGK---HPTFVEGDIR 60 LVTG + IG L + G ++++ N L I R G K HP + + Sbjct: 8 LVTGSTSGIGLGIAQVLARAGANIVL--NGFGDPAPALAEIARHGVKAVHHPADLSDVAQ 65 Query: 61 NEALMTEILHDHA-IDTVIHFAGLKAVGESVQKPLEYYDNNV--------NGTLRLISAM 111 EAL + +D +++ AG++ V Q PLE +D + +GT + M Sbjct: 66 IEALFALAEREFGGVDILVNNAGIQHVAPVEQFPLESWDKIIALNLSAVFHGTRLALPGM 125 Query: 112 RAANVKNFI-FSSSATVYGDQPKIPYVES 139 RA N I +S + G K YV + Sbjct: 126 RARNWGRIINIASVHGLVGSTGKAAYVAA 154 >6NYJ-A nrPDB Length = 821 Score = 30.8 bits (68), Expect = 0.86, Method: Compositional matrix adjust. Identities = 20/47 (42%), Positives = 25/47 (53%), Gaps = 4/47 (8%) Query: 128 YGDQPKIPYVE---SFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWS 171 Y D I VE F + TP++P+G SKLM LT Q A D+S Sbjct: 579 YFDARNIKNVEITRKFASSTPENPWGTSKLMFNN-LTLGQNAVMDYS 624 >1KO7-A nrPDB Length = 314 Score = 30.8 bits (68), Expect = 0.97, Method: Compositional matrix adjust. Identities = 18/54 (33%), Positives = 30/54 (55%), Gaps = 4/54 (7%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVE 56 VL+TG SG S T ++L++ GH ++ DN+ + S + L G+ P +E Sbjct: 147 VLITGDSGIGKSETALELIKRGHRLVADDNVEIREISK----DELIGRAPKLIE 196 >5ZVG-B nrPDB Length = 384 Score = 30.8 bits (68), Expect = 0.99, Method: Compositional matrix adjust. Identities = 16/43 (37%), Positives = 24/43 (55%) Query: 19 QLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 QLL+N ++I +D N R + I+RLG K+ V+ D R Sbjct: 217 QLLENKGEIIAIDKSKNRLRKMEENIKRLGVKNVKLVQMDARK 259 >1QYD-A nrPDB Length = 313 Score = 30.4 bits (67), Expect = 1.0, Method: Compositional matrix adjust. Identities = 32/124 (25%), Positives = 57/124 (45%), Gaps = 21/124 (16%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIIL---DNLCN-SKRSVLPVIERLGGKHPTFVEG 57 RVL+ GG+GYIG + GH +L + + N K +L ++LG K +E Sbjct: 6 RVLIVGGTGYIGKRIVNASISLGHPTYVLFRPEVVSNIDKVQMLLYFKQLGAK---LIEA 62 Query: 58 DIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMR-AANV 116 + + + + L +D VI A+ V +++ L+L+ A++ A N+ Sbjct: 63 SLDDHQRLVDALKQ--VDVVI-----SALAGGV------LSHHILEQLKLVEAIKEAGNI 109 Query: 117 KNFI 120 K F+ Sbjct: 110 KRFL 113 >3SC6-A nrPDB Length = 287 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 35/162 (21%), Positives = 64/162 (39%), Gaps = 24/162 (14%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 RV++TG +G +G +L +D+ D + +L DI N Sbjct: 7 RVIITGANGQLGKQLQEELNPEEYDIYPFD------KKLL----------------DITN 44 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIF 121 + + +++ + +IH A V ++ ++ Y N G + A + K Sbjct: 45 ISQVQQVVQEIRPHIIIHCAAYTKVDQAEKERDLAYVINAIGARNVAVASQLVGAKLVYI 104 Query: 122 SSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDL 163 S+ GD+P+ + F P + YG SK EQ + +L Sbjct: 105 STDYVFQGDRPE--GYDEFHNPAPINIYGASKYAGEQFVKEL 144 >5ILO-A nrPDB Length = 271 Score = 30.4 bits (67), Expect = 1.1, Method: Compositional matrix adjust. Identities = 28/89 (31%), Positives = 42/89 (47%), Gaps = 13/89 (14%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPT----FVEGDI 59 +VTGG+G IG QLL G + + +L ++ L +L HPT ++ D+ Sbjct: 19 VVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDN----LEEFVKLRAAHPTQSVMIIKMDV 74 Query: 60 RN----EALMTEILHDHA-IDTVIHFAGL 83 N EA EI ID V++ AG+ Sbjct: 75 ANKKGVEATYEEIAKTFGNIDIVVNVAGI 103 >5YWN-A nrPDB Length = 334 Score = 29.3 bits (64), Expect = 2.9, Method: Compositional matrix adjust. Identities = 63/315 (20%), Positives = 114/315 (36%), Gaps = 42/315 (13%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 V V+G +GY+ +L G+ V+ S+ + + G V + + Sbjct: 5 VFVSGATGYLAQQIIALVLSKGYKVV---GSVRSEEKGANLKKLYGDDFSYEVVKVLEQK 61 Query: 63 ALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMR--AANVKNFI 120 E L H T+ E E +NGT ++ +++ A + + Sbjct: 62 GAFDEALKKHPEVTIFLHTASPVTFEVEDTEKEILIPAINGTKYVLQSIKDVAPQITRVV 121 Query: 121 FSSSATVY---------------GDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDL-Q 164 ++SS + Y +S G Y SK E+ + + Sbjct: 122 YTSSVVAMSVPEELGSPDVVLSEASWSSLSYEQSKTHGVL--AYFGSKQFAERAAWEFVE 179 Query: 165 KAQPDWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPT 224 + +P+++++ + NPV E+ +G N+ + V +D +D P Sbjct: 180 QEKPNFALSTV---NPVYIFGPQAKDEEVKGTLNHSAEMVNSVLKLNKD------DDVPA 230 Query: 225 EDGTGVRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVN------AFSK 278 GT +I V D+A H+ A EK K + + G ++LDVV A Sbjct: 231 TTGT----FIDVRDVAKAHLAAFEKDEAKGERLLLSNTRFNGQTLLDVVRKNFPQLADKL 286 Query: 279 ACGKPVNYHFAPRRE 293 GKP + F+ +E Sbjct: 287 PVGKPHSDDFSAFKE 301 >1JB1-A nrPDB Length = 205 Score = 28.9 bits (63), Expect = 3.2, Method: Compositional matrix adjust. Identities = 14/31 (45%), Positives = 20/31 (64%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNL 33 VL+TG SG S T ++L+Q GH +I D + Sbjct: 37 VLITGDSGVGKSETALELVQRGHRLIADDRV 67 >5IZL-A nrPDB Length = 616 Score = 28.5 bits (62), Expect = 4.6, Method: Compositional matrix adjust. Identities = 19/69 (27%), Positives = 31/69 (44%), Gaps = 4/69 (5%) Query: 148 PYGKSKLMVEQILTDLQKAQPDWSIALLRYFNPVGAHPSGDMG---EDPQGIPNNLMPYI 204 P GK + ++++ +QK + PV A P G E PQGIP + Sbjct: 172 PEGKRQAAIDKMTKKMQKTLENTKFRGAPII-PVAAKPGGPEAPETEAPQGIPELIELLT 230 Query: 205 AQVAVGRRD 213 +Q+++ RD Sbjct: 231 SQISIPTRD 239 >1HE4-A nrPDB Length = 206 Score = 28.5 bits (62), Expect = 4.9, Method: Compositional matrix adjust. Identities = 31/134 (23%), Positives = 56/134 (41%), Gaps = 16/134 (11%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 ++ + G +G G T Q +Q G++V +L + +S R + G + V GD+ Sbjct: 5 KIAIFGATGQTGLTTLAQAVQAGYEVTVL--VRDSSR-----LPSEGPRPAHVVVGDVLQ 57 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIF 121 A + + + D VI G + L G +++AM+A V + Sbjct: 58 AADVDKTVAGQ--DAVIVLLGTR-------NDLSPTTVMSEGARNIVAAMKAHGVDKVVA 108 Query: 122 SSSATVYGDQPKIP 135 +SA + D K+P Sbjct: 109 CTSAFLLWDPTKVP 122 >4NPH-A nrPDB Length = 351 Score = 28.1 bits (61), Expect = 5.1, Method: Compositional matrix adjust. Identities = 28/128 (21%), Positives = 51/128 (39%), Gaps = 13/128 (10%) Query: 130 DQPKIPYVESFPTGTPQSPY----GKSKLMVEQILTDLQKAQPDWSIALLRYFNPVGAHP 185 D+P + V + T + + GK +++ LT +A + ++A A Sbjct: 132 DRPALERVRALFVATTIAEFFRDNGKRVVLLADSLTRYARAAREIALA---------AGE 182 Query: 186 SGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLADGHVV 245 + GE P G+ + L + + +G + S+ F D V L DGH+V Sbjct: 183 TAVSGEYPPGVFSALPRLLERTGMGEKGSITAFYTVLVEGDDMNEPLADEVRSLLDGHIV 242 Query: 246 AMEKLANK 253 +LA + Sbjct: 243 LSRRLAER 250 >4AVY-A nrPDB Length = 242 Score = 28.1 bits (61), Expect = 5.6, Method: Compositional matrix adjust. Identities = 13/29 (44%), Positives = 19/29 (65%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIIL 30 +VLVTGGS IG+ +Q + G +V+ L Sbjct: 13 QVLVTGGSSGIGAAIAMQFAELGAEVVAL 41 >1JAY-A nrPDB Length = 212 Score = 27.7 bits (60), Expect = 6.5, Method: Compositional matrix adjust. Identities = 10/29 (34%), Positives = 19/29 (65%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVII 29 MRV + GG+G +G ++L GH++++ Sbjct: 1 MRVALLGGTGNLGKGLALRLATLGHEIVV 29 >1B65-A nrPDB Length = 375 Score = 27.7 bits (60), Expect = 6.9, Method: Compositional matrix adjust. Identities = 14/44 (31%), Positives = 24/44 (54%) Query: 247 MEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAP 290 +++LA + + I G GN+ D+ AFS A +P+ + AP Sbjct: 266 LKRLARRASIGIGRNGTPGGNNSGDIFIAFSTANQRPMQHRSAP 309 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1UDA-A nrPDB 480 e-136 1I3M-A nrPDB 411 e-115 1Z45-A nrPDB 385 e-107 3ENK-A nrPDB 380 e-106 4LIS-A nrPDB 379 e-105 2C20-A nrPDB 344 3e-95 1GY8-A nrPDB 321 3e-88 4WOK-A nrPDB 313 5e-86 6BI4-A nrPDB 289 9e-79 1KEU-A nrPDB 287 4e-78 1BXK-A nrPDB 286 1e-77 2HUN-A nrPDB 282 1e-76 1R66-A nrPDB 279 1e-75 6BWL-A nrPDB 270 8e-73 1DB3-A nrPDB 266 8e-72 1ORR-A nrPDB 257 4e-69 1OC2-A nrPDB 251 3e-67 6GPK-A nrPDB 250 6e-67 3RUE-A nrPDB 247 5e-66 5UZH-A nrPDB 246 1e-65 2Q1T-A nrPDB 244 5e-65 2Z95-A nrPDB 243 6e-65 2PK3-A nrPDB 239 2e-63 1RKX-A nrPDB 235 2e-62 2PZM-A nrPDB 232 2e-61 2C54-A nrPDB 228 3e-60 1WVG-A nrPDB 224 4e-59 2Q1W-A nrPDB 216 7e-57 3M2P-A nrPDB 199 2e-51 4EJ0-A nrPDB 196 2e-50 3SXP-A nrPDB 192 2e-49 4WKG-A nrPDB 185 2e-47 1EQ2-A nrPDB 176 1e-44 2X86-A nrPDB 175 3e-44 2GN9-A nrPDB 134 6e-32 1ZZE-A nrPDB 103 9e-23 6GCS-E nrPDB 98 5e-21 Sequences not found previously or not previously below threshold: 1N7G-A nrPDB 211 4e-55 1RPN-A nrPDB 198 4e-51 1GFS-A nrPDB 132 3e-31 4BKP-A nrPDB 109 1e-24 4G5H-A nrPDB 109 2e-24 3WMX-A nrPDB 107 5e-24 4J2O-A nrPDB 106 2e-23 1VL0-A nrPDB 98 4e-21 5B6K-A nrPDB 97 9e-21 6AQY-A nrPDB 95 4e-20 2P4H-X nrPDB 92 3e-19 4PVC-A nrPDB 92 4e-19 2NNL-D nrPDB 91 9e-19 4R1T-A nrPDB 89 3e-18 3SC6-A nrPDB 88 6e-18 4WPG-A nrPDB 87 9e-18 4KTT-E nrPDB 86 2e-17 3RFT-A nrPDB 84 6e-17 3HFS-A nrPDB 84 9e-17 4QUK-A nrPDB 82 4e-16 4R1U-A nrPDB 81 7e-16 5U9C-A nrPDB 80 2e-15 2GGS-A nrPDB 79 3e-15 3PVZ-A nrPDB 76 3e-14 1KC3-A nrPDB 71 7e-13 6G2J-P nrPDB 58 5e-09 5YWN-A nrPDB 58 5e-09 4QQR-A nrPDB 57 1e-08 2QYS-A nrPDB 55 4e-08 3SLK-A nrPDB 55 6e-08 3U5T-A nrPDB 54 1e-07 1QYC-A nrPDB 53 2e-07 5ITV-A nrPDB 52 4e-07 4AVY-A nrPDB 52 5e-07 5GUP-L nrPDB 51 7e-07 1UZM-A nrPDB 51 7e-07 2NM0-A nrPDB 51 9e-07 1K2W-A nrPDB 50 2e-06 4B4O-A nrPDB 49 3e-06 2GDZ-A nrPDB 49 3e-06 1GEG-A nrPDB 49 4e-06 5OVL-A nrPDB 48 5e-06 5OVJ-A nrPDB 48 5e-06 2PNF-A nrPDB 48 6e-06 4E6P-A nrPDB 48 7e-06 3WOH-A nrPDB 47 8e-06 3WYE-A nrPDB 47 1e-05 1AE1-A nrPDB 47 1e-05 3RWB-A nrPDB 47 1e-05 4MOW-A nrPDB 47 2e-05 3RKU-A nrPDB 46 2e-05 3WTC-A nrPDB 46 2e-05 5ILO-A nrPDB 45 4e-05 1BDB-A nrPDB 45 4e-05 3A28-C nrPDB 45 5e-05 1QYD-A nrPDB 45 5e-05 2HRB-A nrPDB 45 6e-05 3OSU-A nrPDB 44 8e-05 1HE4-A nrPDB 44 9e-05 3KZV-A nrPDB 44 1e-04 4KMS-A nrPDB 44 1e-04 2V6G-A nrPDB 44 1e-04 1GEE-A nrPDB 44 1e-04 1YXM-A nrPDB 44 1e-04 1H5Q-A nrPDB 44 1e-04 3PXX-A nrPDB 43 2e-04 6CGE-A nrPDB 43 2e-04 1A27-A nrPDB 43 2e-04 2CFC-A nrPDB 43 2e-04 3OML-A nrPDB 43 2e-04 4K6F-A nrPDB 43 2e-04 3EMK-A nrPDB 43 2e-04 3VZS-A nrPDB 43 2e-04 2O23-A nrPDB 42 3e-04 1N5D-A nrPDB 42 3e-04 3EZL-A nrPDB 42 3e-04 4DBZ-A nrPDB 42 3e-04 3RSH-A nrPDB 42 3e-04 3F9I-A nrPDB 42 4e-04 1AHH-A nrPDB 42 4e-04 6CI9-A nrPDB 42 4e-04 2GAS-A nrPDB 42 5e-04 3U9L-A nrPDB 42 5e-04 1OOE-A nrPDB 42 5e-04 3ZV3-A nrPDB 41 6e-04 3AUT-A nrPDB 41 7e-04 2AE2-A nrPDB 41 7e-04 5PGZ-A nrPDB 41 8e-04 3D3W-A nrPDB 41 8e-04 5VT6-A nrPDB 41 9e-04 5LCX-A nrPDB 41 9e-04 3DWF-A nrPDB 40 0.001 3UN1-A nrPDB 40 0.001 3GRP-A nrPDB 40 0.001 3V8B-A nrPDB 40 0.001 1CYD-A nrPDB 40 0.002 4CQL-A nrPDB 40 0.002 4NBT-A nrPDB 40 0.002 5IZ4-A nrPDB 40 0.002 4FC7-A nrPDB 40 0.002 5JS6-A nrPDB 40 0.002 2HSD-A nrPDB 39 0.002 4IIV-A nrPDB 39 0.002 4IIN-A nrPDB 39 0.003 3BHI-A nrPDB 39 0.003 1HXH-A nrPDB 39 0.003 3V2G-A nrPDB 39 0.003 1Q7C-A nrPDB 39 0.003 5WQO-A nrPDB 39 0.003 6NRP-A nrPDB 39 0.003 3O26-A nrPDB 39 0.004 5B1Y-A nrPDB 39 0.004 2UVD-A nrPDB 39 0.004 1O89-A nrPDB 38 0.005 2C07-A nrPDB 38 0.005 2EW8-A nrPDB 38 0.005 2CDH-G nrPDB 38 0.006 4NBV-A nrPDB 38 0.006 4BO1-A nrPDB 38 0.006 5L51-A nrPDB 38 0.006 2Q4B-A nrPDB 38 0.007 3KYB-A nrPDB 38 0.007 3R3S-A nrPDB 38 0.007 4IS3-A nrPDB 37 0.010 3OEC-A nrPDB 37 0.011 3PPI-A nrPDB 37 0.012 1JAY-A nrPDB 37 0.017 5D01-A nrPDB 36 0.019 6D9T-A nrPDB 36 0.022 5CDY-A nrPDB 36 0.026 3W8F-A nrPDB 36 0.027 1E3W-A nrPDB 36 0.028 3OIC-A nrPDB 35 0.031 4XRR-A nrPDB 35 0.032 2B4Q-A nrPDB 35 0.041 5ER0-A nrPDB 35 0.042 4HP8-A nrPDB 35 0.043 4CR6-A nrPDB 35 0.046 3O4R-A nrPDB 35 0.055 2PH3-A nrPDB 34 0.070 2CZG-A nrPDB 34 0.075 5F5N-A nrPDB 34 0.080 5T5Q-A nrPDB 34 0.093 5O3Z-A nrPDB 34 0.097 4G65-A nrPDB 34 0.11 2X9N-A nrPDB 34 0.12 5OJG-A nrPDB 34 0.14 3ORF-A nrPDB 33 0.16 2DKN-A nrPDB 33 0.17 2BGM-A nrPDB 33 0.20 2ZAT-A nrPDB 33 0.21 4JRO-A nrPDB 33 0.24 2BC1-A nrPDB 32 0.25 3FTP-A nrPDB 32 0.27 3MJ4-A nrPDB 32 0.28 5OKP-A nrPDB 32 0.31 3NR8-B nrPDB 32 0.31 2DC1-A nrPDB 32 0.32 4RZH-A nrPDB 32 0.33 5GXF-A nrPDB 32 0.36 1P33-A nrPDB 32 0.48 3H0K-A nrPDB 32 0.48 4RZI-B nrPDB 32 0.54 3UVE-A nrPDB 32 0.55 4TRR-A nrPDB 31 0.57 2YV2-A nrPDB 31 0.63 5DBI-A nrPDB 31 0.70 2G17-A nrPDB 31 0.78 4DMM-A nrPDB 31 0.95 2JJM-A nrPDB 30 1.0 2ZCU-A nrPDB 30 1.2 5NUE-A nrPDB 30 1.2 2EXX-A nrPDB 30 1.3 2PV7-A nrPDB 30 1.5 3TQF-A nrPDB 30 1.6 1MV8-A nrPDB 30 1.7 1DIR-A nrPDB 30 1.7 5GZU-A nrPDB 30 1.8 4R16-A nrPDB 30 1.8 4UUP-A nrPDB 30 2.1 5ENV-A nrPDB 30 2.1 1LSS-A nrPDB 29 2.2 1VRD-A nrPDB 29 2.4 5B37-A nrPDB 29 2.4 4UUO-A nrPDB 29 2.7 4UUM-A nrPDB 29 2.8 1YB2-A nrPDB 29 2.8 2VK2-A nrPDB 29 3.0 1X1H-A nrPDB 29 3.0 4A10-A nrPDB 29 3.1 1FUI-A nrPDB 29 3.1 4TVO-A nrPDB 29 3.4 5DT9-A nrPDB 29 3.7 1DXY-A nrPDB 29 3.7 1W73-A nrPDB 29 3.7 1VIM-A nrPDB 29 3.8 6ACF-A nrPDB 29 4.3 5N2I-A nrPDB 29 4.4 1IE3-A nrPDB 29 4.6 5O7H-B nrPDB 28 4.8 4E0B-A nrPDB 28 5.7 4LDX-A nrPDB 28 5.8 4M8S-A nrPDB 28 6.8 4D3V-A nrPDB 28 6.9 3ATQ-A nrPDB 28 7.4 5UQG-A nrPDB 27 8.5 >1UDA-A nrPDB Length = 338 Score = 480 bits (1235), Expect = e-136, Method: Composition-based stats. Identities = 337/338 (99%), Positives = 337/338 (99%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR Sbjct: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI Sbjct: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120 Query: 121 FSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNP 180 FSSSATVYGD PKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNP Sbjct: 121 FSSSATVYGDNPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNP 180 Query: 181 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA 240 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA Sbjct: 181 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA 240 Query: 241 DGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDLPAYW 300 DGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDLPAYW Sbjct: 241 DGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDLPAYW 300 Query: 301 ADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGYPD 338 ADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGYPD Sbjct: 301 ADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGYPD 338 >1I3M-A nrPDB Length = 348 Score = 411 bits (1056), Expect = e-115, Method: Composition-based stats. Identities = 178/341 (52%), Positives = 236/341 (69%), Gaps = 6/341 (1%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKR------SVLPVIERLGGKHPTFV 55 +VLVTGG+GYIGSHT ++LL+ G+ +++DN N+ R L ++ L G+ F Sbjct: 4 KVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFE 63 Query: 56 EGDIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAAN 115 E DI ++ + + ++ VIHFAGLKA+GESVQKPL+YY N+ GT++L+ M+A Sbjct: 64 EMDILDQGALQRLFKKYSFMAVIHFAGLKAMGESVQKPLDYYRVNLTGTIQLLEIMKAHG 123 Query: 116 VKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALL 175 VKN +FSSSATVYG+ +P E+ PTG +PYGKSK +E+++ DL +A W++ LL Sbjct: 124 VKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNVVLL 183 Query: 176 RYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIH 235 RYFNP GAH SG +GEDPQGIPNNLMPY++QVA+GRR++L +FGNDY TEDGTGVRDYIH Sbjct: 184 RYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIH 243 Query: 236 VMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGD 295 V+DLA GH+ A+ KL + G IYNLG G G SVL +V A KA GK + Y RREGD Sbjct: 244 VVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGD 303 Query: 296 LPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGY 336 + A +A+ S A EL W LD M +D W WQ ++P G+ Sbjct: 304 VAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGF 344 >1Z45-A nrPDB Length = 699 Score = 385 bits (988), Expect = e-107, Method: Composition-based stats. Identities = 169/343 (49%), Positives = 227/343 (66%), Gaps = 10/343 (2%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 VLVTGG+GYIGSHT V+L++NG+D ++ DNL NS + +E L H F E D+ + Sbjct: 14 VLVTGGAGYIGSHTVVELIENGYDCVVADNLSNSTYDSVARLEVLTKHHIPFYEVDLCDR 73 Query: 63 ALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFS 122 + ++ ++ ID+VIHFAGLKAVGES Q PL YY NN+ GT+ L+ M+ NV F+FS Sbjct: 74 KGLEKVFKEYKIDSVIHFAGLKAVGESTQIPLRYYHNNILGTVVLLELMQQYNVSKFVFS 133 Query: 123 SSATVYGDQPK----IPYVESFPTGTPQSPYGKSKLMVEQILTDLQKA-QPDWSIALLRY 177 SSATVYGD + IP E P G P +PYG +K +E IL DL + + W A+LRY Sbjct: 134 SSATVYGDATRFPNMIPIPEECPLG-PTNPYGHTKYAIENILNDLYNSDKKSWKFAILRY 192 Query: 178 FNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVM 237 FNP+GAHPSG +GEDP GIPNNL+PY+AQVAVGRR+ L IFG+DY + DGT +RDYIHV+ Sbjct: 193 FNPIGAHPSGLIGEDPLGIPNNLLPYMAQVAVGRREKLYIFGDDYDSRDGTPIRDYIHVV 252 Query: 238 DLADGHVVAMEKL----ANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRRE 293 DLA GH+ A++ L N+ +NLG+G G++V +V +AF KA G + Y RR Sbjct: 253 DLAKGHIAALQYLEAYNENEGLCREWNLGSGKGSTVFEVYHAFCKASGIDLPYKVTGRRA 312 Query: 294 GDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGY 336 GD+ A +A REL W+ +++ +D W W + +P GY Sbjct: 313 GDVLNLTAKPDRAKRELKWQTELQVEDSCKDLWKWTTENPFGY 355 >3ENK-A nrPDB Length = 341 Score = 380 bits (975), Expect = e-106, Method: Composition-based stats. Identities = 180/334 (53%), Positives = 229/334 (68%), Gaps = 1/334 (0%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 +LVTGG+GYIGSHT V+LL +G+DV+I DNL NSKR + IE++ GK P F E D+ +E Sbjct: 8 ILVTGGAGYIGSHTAVELLAHGYDVVIADNLVNSKREAIARIEKITGKTPAFHETDVSDE 67 Query: 63 ALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFS 122 + I H I IHFA LKAVGESV KP+EYY NN++ L L+ MR VK +FS Sbjct: 68 RALARIFDAHPITAAIHFAALKAVGESVAKPIEYYRNNLDSLLSLLRVMRERAVKRIVFS 127 Query: 123 SSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNPVG 182 SSATVYG + P E+FP + +PYG++KLM EQIL D++ A P W +A LRYFNPVG Sbjct: 128 SSATVYGVPERSPIDETFPL-SATNPYGQTKLMAEQILRDVEAADPSWRVATLRYFNPVG 186 Query: 183 AHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLADG 242 AH SG +GEDP GIPNNLMPY+AQVAVG+ + L +FG+DYPT DGTGVRDYIHV+DLA G Sbjct: 187 AHESGLIGEDPAGIPNNLMPYVAQVAVGKLEKLRVFGSDYPTPDGTGVRDYIHVVDLARG 246 Query: 243 HVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDLPAYWAD 302 H+ A++ L + NLG G G SVL+VV AF KA G+ V Y RR GD+ +A+ Sbjct: 247 HIAALDALERRDASLTVNLGTGRGYSVLEVVRAFEKASGRAVPYELVARRPGDVAECYAN 306 Query: 303 ASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGY 336 + A + W+ R L+ M D W WQ +P+G+ Sbjct: 307 PAAAAETIGWKAERDLERMCADHWRWQENNPRGF 340 >4LIS-A nrPDB Length = 371 Score = 379 bits (973), Expect = e-105, Method: Composition-based stats. Identities = 175/353 (49%), Positives = 234/353 (66%), Gaps = 20/353 (5%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 VLVTGG+GYIGS T + LL+ G+ V++ DNL NS L IE + GK F + D+ +E Sbjct: 6 VLVTGGTGYIGSFTTLALLEAGYKVVVADNLYNSSAEALNRIELISGKKAEFAQLDVTDE 65 Query: 63 ALMTEILHDH-AIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIF 121 A ++ H ID+VIHFA LKAVGES +KPL+YY NV GT+ L+ +M NV N +F Sbjct: 66 AAFDKVFEAHPDIDSVIHFAALKAVGESGEKPLDYYHVNVYGTICLLRSMVRHNVTNIVF 125 Query: 122 SSSATVYGDQPK----IPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPD-------- 169 SSSATVYGD + IP E P G P +PYG +K +E +TD+ AQ + Sbjct: 126 SSSATVYGDATRFPDMIPIPEHCPLG-PTNPYGNTKFAIELAITDVINAQRNNAKKAGNE 184 Query: 170 -----WSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPT 224 W+ ALLRYFNP GAHPSG MGEDPQG+P NL+P +AQVA G+R+ L +FG+DY + Sbjct: 185 TEAAKWNGALLRYFNPAGAHPSGIMGEDPQGVPYNLLPLLAQVATGKREKLLVFGDDYAS 244 Query: 225 EDGTGVRDYIHVMDLADGHVVAMEKL-ANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKP 283 DGT +RDYIH++DLADGH+ A+ L AN PGV +NLG G G++V +++ AFSKA G+ Sbjct: 245 HDGTAIRDYIHILDLADGHLKALNYLRANNPGVRAWNLGTGRGSTVYEMIRAFSKAVGRD 304 Query: 284 VNYHFAPRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGY 336 + Y APRR GD+ ++ ++A+ EL W+ RTL++ +D W W +PQGY Sbjct: 305 LPYEVAPRRAGDVLNLTSNPTRANTELGWKAQRTLEQACEDLWLWTKNNPQGY 357 >2C20-A nrPDB Length = 330 Score = 344 bits (883), Expect = 3e-95, Method: Composition-based stats. Identities = 121/335 (36%), Positives = 184/335 (54%), Gaps = 11/335 (3%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 +L+ GG+GYIGSH +L+ G V+++DNL E + F GD+R++ Sbjct: 4 ILICGGAGYIGSHAVKKLVDEGLSVVVVDNLQTGH-------EDAITEGAKFYNGDLRDK 56 Query: 63 ALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFS 122 A + ++ I+ V+HFA VG S++KPL+YY+NNV G L L+ M V FIFS Sbjct: 57 AFLRDVFTQENIEAVMHFAADSLVGVSMEKPLQYYNNNVYGALCLLEVMDEFKVDKFIFS 116 Query: 123 SSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNPVG 182 S+A YG+ + + P + YG++KL +E++L +A + + RYFN G Sbjct: 117 STAATYGEV-DVDLITEETMTNPTNTYGETKLAIEKMLHWYSQA-SNLRYKIFRYFNVAG 174 Query: 183 AHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLADG 242 A P+G +GED + +L+P + QVA+G+R+ + +FG+DY T DGT +RDYIHV DL Sbjct: 175 ATPNGIIGEDHRP-ETHLIPLVLQVALGQREKIMMFGDDYNTPDGTCIRDYIHVEDLVAA 233 Query: 243 HVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDLPAYWAD 302 H + ++ L N YNLG G G SV ++V+A + + APRR GD A Sbjct: 234 HFLGLKDLQNGGESDFYNLGNGNGFSVKEIVDAVREVTNHEIPAEVAPRRAGDPARLVAS 293 Query: 303 ASKADRELNWRVT-RTLDEMAQDTWHWQSRHPQGY 336 + KA +L W + + + W+W + P GY Sbjct: 294 SQKAKEKLGWDPRYVNVKTIIEHAWNWHQKQPNGY 328 >1GY8-A nrPDB Length = 397 Score = 321 bits (822), Expect = 3e-88, Method: Composition-based stats. Identities = 139/381 (36%), Positives = 196/381 (51%), Gaps = 46/381 (12%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQN-GHDVIILDNLCNSK---------RSVLPVIERLGGK 50 MRVLV GG+GYIGSH LL++ H V+I+D+L + +V +++ G Sbjct: 3 MRVLVCGGAGYIGSHFVRALLRDTNHSVVIVDSLVGTHGKSDHVETRENVARKLQQSDGP 62 Query: 51 HPTFVE-------GDIRNEALMTEILHDHAI-DTVIHFAGLKAVGESVQKPLEYYDNNVN 102 P + + GD+RNE + + H D V+H AVGESV+ PL+YYDNNV Sbjct: 63 KPPWADRYAALEVGDVRNEDFLNGVFTRHGPIDAVVHMCAFLAVGESVRDPLKYYDNNVV 122 Query: 103 GTLRLISAMRAANVKNFIFSSSATVYGDQ------PKIPYVESFPTGTPQSPYGKSKLMV 156 G LRL+ AM IFSSSA ++G+ ++ +P+SPYG+SKL+ Sbjct: 123 GILRLLQAMLLHKCDKIIFSSSAAIFGNPTMGSVSTNAEPIDINAKKSPESPYGESKLIA 182 Query: 157 EQILTDLQKAQPDWSIALLRYFNPVGAHPSGDMGEDPQG----IPNNLMPYIAQVAVGRR 212 E+++ D +A I LRYFN GAH GD+GE QG IP L ++ +A +R Sbjct: 183 ERMIRDCAEAYGIKGIC-LRYFNACGAHEDGDIGEHYQGSTHLIPIILGRVMSDIAPDQR 241 Query: 213 ----------DSLAIFGNDYPTEDGTGVRDYIHVMDLADGHVVAMEKLANKPGVH----- 257 + IFG DYPT DGT VRDY+HV DLA H++A++ + Sbjct: 242 LTIHEDASTDKRMPIFGTDYPTPDGTCVRDYVHVCDLASAHILALDYVEKLGPNDKSKYF 301 Query: 258 -IYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDLPAYWADASKADRELNWRVTR 316 ++NLG G SV +V+ K G P+ RREGD A + KA L W+ Sbjct: 302 SVFNLGTSRGYSVREVIEVARKTTGHPIPVRECGRREGDPAYLVAASDKAREVLGWKPKY 361 Query: 317 -TLDEMAQDTWHWQSRHPQGY 336 TL+ + + +W +Q HP GY Sbjct: 362 DTLEAIMETSWKFQRTHPNGY 382 >4WOK-A nrPDB Length = 336 Score = 313 bits (803), Expect = 5e-86, Method: Composition-based stats. Identities = 127/323 (39%), Positives = 173/323 (53%), Gaps = 12/323 (3%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 VLV GG+G+IGSHT L G+ ++ DNL +S + FVEGDI + Sbjct: 13 NVLVVGGAGFIGSHTAKLLAGQGYAPVVYDNLSTGHQSAVRW--------GDFVEGDILD 64 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIF 121 +A + E + +A VIHFA VGESV+ P +YY NNV GT L+ A R +N IF Sbjct: 65 QARLVETMEKYAPVAVIHFAASAYVGESVEDPAKYYRNNVGGTQSLLDACRLTRTQNVIF 124 Query: 122 SSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNPV 181 SSS YG ++P E P +PYG++KL+ E +L D A LRYFN Sbjct: 125 SSSCATYGVPSRLPIGEG-EAQNPINPYGRTKLIAEHMLADYAVAY-GLRYVALRYFNAS 182 Query: 182 GAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLAD 241 GA G++GE +L+P A GR D L ++G+DY T DGT +RDYIHV DLA Sbjct: 183 GADIDGELGEKHDP-ETHLIPRAMMAAAGRLDVLEVYGDDYETPDGTCIRDYIHVTDLAR 241 Query: 242 GHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDLPAYWA 301 HV+A+E L G NLG G G S+ ++V + + G+ V RR GD PA +A Sbjct: 242 AHVLAVEHLKEAGGNLAVNLGTGRGTSIREIVQSIGRLTGRSVPVAMRARRAGDPPALYA 301 Query: 302 DASKADRELNWRVTRT-LDEMAQ 323 D + A +L + + LD + + Sbjct: 302 DPALAAEKLGFHTVYSDLDTIIR 324 >6BI4-A nrPDB Length = 346 Score = 289 bits (740), Expect = 9e-79, Method: Composition-based stats. Identities = 90/340 (26%), Positives = 153/340 (45%), Gaps = 31/340 (9%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQ--NGHDVIILDNLCNSKRSVLPVIERL-GGKHPTFVEG 57 M +LVTGG+G+IGS+ +LQ + +I D L S L ++ + + FV+G Sbjct: 25 MNILVTGGAGFIGSNFVHYMLQSYETYKIINFDALTYSGN--LNNVKSIQDHPNYYFVKG 82 Query: 58 DIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVK 117 +I+N L+ ++ + + +++FA V S++ P+ +YD NV GT+ L+ ++ Sbjct: 83 EIQNGELLEHVIKERDVQVIVNFAAESHVDRSIENPIPFYDTNVIGTVTLLELVKKYPHI 142 Query: 118 NFIFSSSATVYGDQPKIP-YVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLR 176 + S+ VYG K + E P P SPY SK + I K + + R Sbjct: 143 KLVQVSTDEVYGSLGKTGRFTEETPLA-PNSPYSSSKASADMIALAYYKTY-QLPVIVTR 200 Query: 177 YFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHV 236 N G P P L+P + A+ + L ++G DG VRD++HV Sbjct: 201 CSNNYG----------PYQYPEKLIPLMVTNALEGK-KLPLYG------DGLNVRDWLHV 243 Query: 237 MDLADGHVVAMEKLANKPGVH-IYNLGAGVGNSVLDVVNAFSKACGK-PVNYHFAPRREG 294 D H A++ + +K V +YN+G + ++VV GK + + R G Sbjct: 244 TD----HCSAIDVVLHKGRVGEVYNIGGNNEKTNVEVVEQIITLLGKTKKDIEYVTDRLG 299 Query: 295 DLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQ 334 Y +A K E +W T ++ Q+T W ++ + Sbjct: 300 HDRRYAINAEKMKNEFDWEPKYTFEQGLQETVQWYEKNEE 339 >1KEU-A nrPDB Length = 361 Score = 287 bits (735), Expect = 4e-78, Method: Composition-based stats. Identities = 87/361 (24%), Positives = 135/361 (37%), Gaps = 49/361 (13%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 M++L+TGG+G+IGS +++N D ++ + ++ + + F DI Sbjct: 1 MKILITGGAGFIGSAVVRHIIKNTQDTVVNIDKLTYAGNLESLSDISESNRYNFEHADIC 60 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAA------ 114 + A +T I + D V+H A V S+ P + + N+ GT L+ R Sbjct: 61 DSAEITRIFEQYQPDAVMHLAAESHVDRSITGPAAFIETNIVGTYALLEVARKYWSALGE 120 Query: 115 ---NVKNFIFSSSATVYGDQPKIPYVE---------SFPTGTPQSPYGKSKLMVEQILTD 162 N F S+ VYGD P VE P SPY SK + ++ Sbjct: 121 DKKNNFRFHHISTDEVYGDLPHPDEVENSVTLPLFTETTAYAPSSPYSASKASSDHLVRA 180 Query: 163 LQKAQPDWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDY 222 ++ + N G P P L+P + A+ + L I+G Sbjct: 181 WRRTY-GLPTIVTNCSNNYG----------PYHFPEKLIPLVILNALEGK-PLPIYGK-- 226 Query: 223 PTEDGTGVRDYIHVMDLADG-HVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACG 281 G +RD+++V D A H+V E A YN+G LDVV Sbjct: 227 ----GDQIRDWLYVEDHARALHMVVTEGKAG----ETYNIGGHNEKKNLDVVFTICDLLD 278 Query: 282 KPVN--------YHFAPRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHP 333 + V + R G Y DA K REL W+ T + + T W + Sbjct: 279 EIVPKATSYREQITYVADRPGHDRRYAIDAGKISRELGWKPLETFESGIRKTVEWYLANT 338 Query: 334 Q 334 Q Sbjct: 339 Q 339 >1BXK-A nrPDB Length = 355 Score = 286 bits (731), Expect = 1e-77, Method: Composition-based stats. Identities = 87/358 (24%), Positives = 141/358 (39%), Gaps = 49/358 (13%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHD-VIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 ++L+TGG+G+IGS ++ D V+++D L + +++ + + F + DI Sbjct: 3 KILITGGAGFIGSALVRYIINETSDAVVVVDKLTYAG-NLMSLAPVAQSERFAFEKVDIC 61 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAA------ 114 + A + + +H D V+H A V S+ P + + N+ GT L+ A RA Sbjct: 62 DRAELARVFTEHQPDCVMHLAAESHVDRSIDGPAAFIETNIVGTYTLLEAARAYWNALTE 121 Query: 115 ---NVKNFIFSSSATVYGDQPKIP--YVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPD 169 + F S+ VYGD + E+ P P SPY SK + ++ Sbjct: 122 DKKSAFRFHHISTDEVYGDLHSTDDFFTETTPYA-PSSPYSASKASSDHLVR-------- 172 Query: 170 WSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTG 229 A LR + + P P L+P + A+ + SL ++GN G Sbjct: 173 ---AWLRTYGLPTLITNCSNNYGPYHFPEKLIPLMILNALAGK-SLPVYGN------GQQ 222 Query: 230 VRDYIHVMDLADGHVVAMEKLANKPGVH-IYNLGAGVGNSVLDVVNAFSKACGKPVN--- 285 +RD+++V D A A+ +A V YN+G LDVV + + Sbjct: 223 IRDWLYVEDHAR----ALYCVATTGKVGETYNIGGHNERKNLDVVETICELLEELAPNKP 278 Query: 286 ---------YHFAPRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQ 334 F R G Y DASK REL T + + T W + Sbjct: 279 HGVAHYRDLITFVADRPGHDLRYAIDASKIARELGCVPQETFESGMRKTVQWYLANES 336 >2HUN-A nrPDB Length = 336 Score = 282 bits (722), Expect = 1e-76, Method: Composition-based stats. Identities = 94/339 (27%), Positives = 152/339 (44%), Gaps = 33/339 (9%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHD--VIILDNL-CNSKRSVLPVIERLGGKHPTFVEG 57 M++LVTGG G+IGS+ +L+ D VI +D L S + L +E TFV+G Sbjct: 4 MKLLVTGGMGFIGSNFIRYILEKHPDWEVINIDKLGYGSNPANLKDLED--DPRYTFVKG 61 Query: 58 DIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVK 117 D+ + L+ E++ +D V+H A V S+ P + +NV GT L+ ++R N + Sbjct: 62 DVADYELVKELVR--KVDGVVHLAAESHVDRSISSPEIFLHSNVIGTYTLLESIRRENPE 119 Query: 118 -NFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLR 176 F+ S+ VYGD K + E+ P SPY +K + ++ + R Sbjct: 120 VRFVHVSTDEVYGDILKGSFTEN-DRLMPSSPYSATKAASDMLV-----------LGWTR 167 Query: 177 YFNPVGAHPSGDMGEDPQGIPNNLMP-YIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIH 235 +N + P P L+P I + ++G + + I+G G VRD+++ Sbjct: 168 TYNLNASITRCTNNYGPYQFPEKLIPKTIIRASLGLK--IPIYGT------GKNVRDWLY 219 Query: 236 VMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVN-YHFAPRREG 294 V D + + K ++ IYN+ AG + L+VV + GK R G Sbjct: 220 VEDHVRAIELVLLKGESR---EIYNISAGEEKTNLEVVKIILRLMGKGEELIELVEDRPG 276 Query: 295 DLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHP 333 Y D+ K R+L WR T DE + T W ++ Sbjct: 277 HDLRYSLDSWKITRDLKWRPKYTFDEGIKKTIDWYLKNE 315 >1R66-A nrPDB Length = 337 Score = 279 bits (714), Expect = 1e-75, Method: Composition-based stats. Identities = 87/339 (25%), Positives = 137/339 (40%), Gaps = 32/339 (9%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGH------DVIILDNLCNSKRSVLPVIERLGGKHPTF 54 MR+LVTGG+G+IGSH QLL + +VI+LD+L + + F Sbjct: 1 MRLLVTGGAGFIGSHFVRQLLAGAYPDVPADEVIVLDSLTYAGNRA-NLAPVDADPRLRF 59 Query: 55 VEGDIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAA 114 V GDIR+ L+ L +D ++HFA V S+ + + NV GT L+ A Sbjct: 60 VHGDIRDAGLLARELR--GVDAIVHFAAESHVDRSIAGASVFTETNVQGTQTLLQCAVDA 117 Query: 115 NVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIAL 174 V + S+ VYG + ES P P SPY SK + + + + + Sbjct: 118 GVGRVVHVSTDEVYGSIDSGSWTESSPLE-PNSPYAASKAGSDLVARAYHRTY-GLDVRI 175 Query: 175 LRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYI 234 R N G P P L+P + +L ++G DG VR+++ Sbjct: 176 TRCCNNYG----------PYQHPEKLIPLFVTNLLDG-GTLPLYG------DGANVREWV 218 Query: 235 HVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPV-NYHFAPRRE 293 H D G + + A IY++G G+ + ++ + G + R+ Sbjct: 219 HTDDHCRGIALVL---AGGRAGEIYHIGGGLELTNRELTGILLDSLGADWSSVRKVADRK 275 Query: 294 GDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRH 332 G Y D K +REL +R + + T W + Sbjct: 276 GHDLRYSLDGGKIERELGYRPQVSFADGLARTVRWYREN 314 >6BWL-A nrPDB Length = 328 Score = 270 bits (689), Expect = 8e-73, Method: Composition-based stats. Identities = 91/332 (27%), Positives = 143/332 (43%), Gaps = 28/332 (8%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVL-PVIERLGGKHPTFVEGDI 59 M++LVTGG+G+IG +LLQ+ H+V ILDNL NS + + L K ++GDI Sbjct: 1 MKILVTGGAGFIGRWVVKRLLQDKHEVWILDNLANSTTANITEFAHDLNLKQC--IQGDI 58 Query: 60 RNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNF 119 +++ L+ ++ +++ D H A V +S+ ++N+ GT L+ +VK Sbjct: 59 KDKKLVAQLFENNSFDLCYHLAASINVQDSIDDARATFENDTIGTFNLLEQCLNYDVK-M 117 Query: 120 IFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFN 179 +F S+ VY I + P SPY SK+ E ++ A + ++R FN Sbjct: 118 VFMSTCMVYDKATNIQGISELDPIKPASPYAGSKIAAENMVLSYYYAYK-LPVVVIRPFN 176 Query: 180 PVGA-HPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMD 238 G +G G NN + + L I+G DG RD ++V D Sbjct: 177 TYGPFQKTGGEGGVVAIFINNKLDNV---------PLNIYG------DGKQTRDLLYVED 221 Query: 239 LADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAP--RREGDL 296 AD VVA A G HI N G G S+ + G V+ + ++ Sbjct: 222 CAD-FVVAAGYSAKANG-HIINAGTGQDISINKLAELI---SGNKVSIQHVTHIHPQSEI 276 Query: 297 PAYWADASKADRELNWRVTRTLDEMAQDTWHW 328 + KA LNW +L++ T W Sbjct: 277 QKLLCNYEKAKTILNWEPKVSLEDGVIKTEEW 308 >1DB3-A nrPDB Length = 372 Score = 266 bits (680), Expect = 8e-72, Method: Composition-based stats. Identities = 84/351 (23%), Positives = 145/351 (41%), Gaps = 37/351 (10%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNS--KRSVLPVIERLGGKHPTFV--EGDI 59 L+TG +G GS+ LL+ G++V + +S V + + +P F GD+ Sbjct: 5 LITGVTGQDGSYLAEFLLEKGYEVHGIKRRASSFNTERVDHIYQDPHTCNPKFHLHYGDL 64 Query: 60 RNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVK-- 117 + + +T IL + D V + + V S + P D + GTLRL+ A+R ++ Sbjct: 65 SDTSNLTRILREVQPDEVYNLGAMSHVAVSFESPEYTADVDAMGTLRLLEAIRFLGLEKK 124 Query: 118 -NFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLR 176 F +S++ +YG +IP E+ P P+SPY +KL I + +++ ++ + Sbjct: 125 TRFYQASTSELYGLVQEIPQKETTPF-YPRSPYAVAKLYAYWITVNYRESYGMYACNGI- 182 Query: 177 YFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHV 236 FN H S GE + + IA +A G L + GN D +DY+ + Sbjct: 183 LFN----HESPRRGE--TFVTRKITRAIANIAQGLESCLYL-GNMDSLRDWGHAKDYVKM 235 Query: 237 MDLA------DGHVVA----------MEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKAC 280 + + V+A +E A + G+ + G GV + V A Sbjct: 236 QWMMLQQEQPEDFVIATGVQYSVRQFVEMAAAQLGIKLRFEGTGVEEKGIVVSVTGHDAP 295 Query: 281 GKP-----VNYHFAPRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTW 326 G + R ++ D +KA +L W+ TL EM + Sbjct: 296 GVKPGDVIIAVDPRYFRPAEVETLLGDPTKAHEKLGWKPEITLREMVSEMV 346 >1ORR-A nrPDB Length = 347 Score = 257 bits (657), Expect = 4e-69, Method: Composition-based stats. Identities = 97/352 (27%), Positives = 151/352 (42%), Gaps = 40/352 (11%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCN-SKRSVLPVIERLGGKHPTFVEGDIR 60 ++L+TGG G++GS+ L G D+I+ DNL L + LG + FV GDIR Sbjct: 3 KLLITGGCGFLGSNLASFALSQGIDLIVFDNLSRKGATDNLHWLSSLG--NFEFVHGDIR 60 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVK-NF 119 N+ +T ++ + D+ H AG A+ S+ P ++ NV GTL L+ A+R N N Sbjct: 61 NKNDVTRLITKYMPDSCFHLAGQVAMTTSIDNPCMDFEINVGGTLNLLEAVRQYNSNCNI 120 Query: 120 IFSSSATVYGDQPKIPYVESF--------PTGTPQ-------SPYGKSKLMVEQILTDLQ 164 I+SS+ VYGD + Y E+ P G + SPYG SK +Q + D Sbjct: 121 IYSSTNKVYGDLEQYKYNETETRYTCVDKPNGYDESTQLDFHSPYGCSKGAADQYMLDYA 180 Query: 165 KAQPDWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAV----GRRDSLAIFGN 220 + + V H S G + + Q AV G I GN Sbjct: 181 R--------IFGLNTVVFRHSSMYGGRQFATYDQGWVGWFCQKAVEIKNGINKPFTISGN 232 Query: 221 DYPTEDGTGVRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGN--SVLDVVNAFSK 278 G VRD +H D+ + A+ ++ G + +N+G + N S+L++ Sbjct: 233 ------GKQVRDVLHAEDMISLYFTALANVSKIRG-NAFNIGGTIVNSLSLLELFKLLED 285 Query: 279 ACGKPVNYHFAPRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQS 330 C + + P RE D + AD K ++W + + Q + W S Sbjct: 286 YCNIDMRFTNLPVRESDQRVFVADIKKITNAIDWSPKVSAKDGVQKMYDWTS 337 >1OC2-A nrPDB Length = 348 Score = 251 bits (641), Expect = 3e-67, Method: Composition-based stats. Identities = 86/350 (24%), Positives = 134/350 (38%), Gaps = 49/350 (14%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVII--LDNLCNSKRSVLPVIERLGGKHPTFVEGDI 59 ++VTGG+G+IGS+ + N DV + LD L + +E + G V GDI Sbjct: 6 NIIVTGGAGFIGSNFVHYVYNNHPDVHVTVLDKLTYAGNKA--NLEAILGDRVELVVGDI 63 Query: 60 RNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNF 119 + L+ ++ D ++H+A S+ P + N GT L+ A R ++ F Sbjct: 64 ADAELVDKLAA--KADAIVHYAAESHNDNSLNDPSPFIHTNFIGTYTLLEAARKYDI-RF 120 Query: 120 IFSSSATVYGDQPKIPYVESFP--------------TGTPQSPYGKSKLMVEQILTDLQK 165 S+ VYGD +P E P P SPY +K + I+ Sbjct: 121 HHVSTDEVYGD---LPLREDLPGHGEGPGEKFTAETNYNPSSPYSSTKAASDLIVK---- 173 Query: 166 AQPDWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMP-YIAQVAVGRRDSLAIFGNDYPT 224 A +R F + P +P I + G + L Sbjct: 174 -------AWVRSFGVKATISNCSNNYGPYQHIEKFIPRQITNILAGIKPKLY-------- 218 Query: 225 EDGTGVRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPV 284 +G VRD+IH D + G + K + G Y +GA + +V+ + G+P Sbjct: 219 GEGKNVRDWIHTNDHSTGVWAILTK--GRMG-ETYLIGADGEKNNKEVLELILEKMGQPK 275 Query: 285 N-YHFAPRREGDLPAYWADASKADRELNWRVTRT-LDEMAQDTWHWQSRH 332 + Y R G Y DASK EL W T E ++T W + + Sbjct: 276 DAYDHVTDRAGHDLRYAIDASKLRDELGWTPQFTDFSEGLEETIQWYTDN 325 >6GPK-A nrPDB Length = 373 Score = 250 bits (639), Expect = 6e-67, Method: Composition-based stats. Identities = 79/350 (22%), Positives = 150/350 (42%), Gaps = 34/350 (9%) Query: 1 MR--VLVTGGSGYIGSHTCVQLLQNGHDV--IILDNLCNSKRSVLPVIERLGGK---HPT 53 MR L+TG +G GS+ LL+ G++V I+ + + + + + + Sbjct: 23 MRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMK 82 Query: 54 FVEGDIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRA 113 GD+ + + +I+++ + + V S D + GTLRL+ A++ Sbjct: 83 LHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKT 142 Query: 114 ANVKN---FIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDW 170 + N F +S++ +YG +IP E+ P P+SPYG +KL I+ + ++A + Sbjct: 143 CGLINSVKFYQASTSQLYGKVQEIPQKETTPF-YPRSPYGAAKLYAYWIVVNFREAYNLF 201 Query: 171 SIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGV 230 ++ + FN H S G + + + +A++ +G+ + ++ GN D Sbjct: 202 AVNGI-LFN----HESPRRGAN--FVTRKISRSVAKIYLGQLECFSL-GNLDAKRDWGHA 253 Query: 231 RDYIHVMDL------------ADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSK 278 +DY+ M L A G V ++ + K +HI G + +V K Sbjct: 254 KDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEV--GRCK 311 Query: 279 ACGKP-VNYHFAPRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWH 327 GK V R ++ D +KA ++LNW+ DE+ ++ H Sbjct: 312 ETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVH 361 >3RUE-A nrPDB Length = 351 Score = 247 bits (631), Expect = 5e-66, Method: Composition-based stats. Identities = 90/343 (26%), Positives = 158/343 (46%), Gaps = 31/343 (9%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGK----HPTFVEGDI 59 L+TG +G+IGS+ +LL+ VI LDN + L ++ L F+EGDI Sbjct: 29 LITGVAGFIGSNLLEKLLKLNQVVIGLDNFSTGHQYNLDEVKTLVSTEQWSRFCFIEGDI 88 Query: 60 RNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNF 119 R+ +++ +D V+H A L +V S+ P+ N+ G L ++ A + A V++F Sbjct: 89 RDLTTCEQVMK--GVDHVLHQAALGSVPRSIVDPITTNATNITGFLNILHAAKNAQVQSF 146 Query: 120 IFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFN 179 +++S++ YGD P +P VE G P SPY +K V +I + + LRYFN Sbjct: 147 TYAASSSTYGDHPALPKVEE-NIGNPLSPYAVTK-YVNEIYAQVYARTYGFKTIGLRYFN 204 Query: 180 PVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGND-YPTEDGTGVRDYIHVMD 238 G +DP G ++P + + + G+D Y DG RD+ ++ + Sbjct: 205 VFGRR------QDPNGAYAAVIP--------KWTAAMLKGDDVYINGDGETSRDFCYIDN 250 Query: 239 LADGHVV-AMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGK-----PVNYHFAPRR 292 + +++ A+ K + K +IYN+ G ++ ++ ++ + R Sbjct: 251 VIQMNILSALAKDSAKD--NIYNVAVGDRTTLNELSGYIYDELNLIHHIDKLSIKYREFR 308 Query: 293 EGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQG 335 GD+ AD +KA L +R + E + + W R +G Sbjct: 309 SGDVRHSQADVTKAIDLLKYRPNIKIREGLRLSMPWYVRFLKG 351 >5UZH-A nrPDB Length = 345 Score = 246 bits (628), Expect = 1e-65, Method: Composition-based stats. Identities = 77/352 (21%), Positives = 144/352 (40%), Gaps = 47/352 (13%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDV--IILDNLCNSKRSVLPVIERLGGKHPTF--VEGDI 59 L+TG +G GS+ LL+ G+ V II + + V + + + F + GD+ Sbjct: 5 LITGITGQDGSYLAEFLLEKGYMVYGIIRRSSSFNTGRVEHLYKDIHITKAKFKLLYGDL 64 Query: 60 RNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVK-- 117 + + I+ D + + A V S + P + + GTLRL+ A+RA ++ Sbjct: 65 TDTGNLISIIAKIKPDEIYNLAAQSHVKVSFEMPEYTANVDGIGTLRLLEAIRACGLEKK 124 Query: 118 -NFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLR 176 F +S++ +YG ++P E+ P P+SPY +KL I+ + ++A +++ + Sbjct: 125 TKFYQASTSELYGLVQEVPQKETTPF-YPRSPYACAKLYSYWIVVNYREAYNMFALNGI- 182 Query: 177 YFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHV 236 FN H S G P + + +A++ +G +D L + GN D +DY+ Sbjct: 183 LFN----HESIRRG--PTFVTRKITMAVARIKLGLQDCLYL-GNLDAERDWGHAKDYVEA 235 Query: 237 MDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYH--------- 287 M L L + + + G +SV + V G+ V + Sbjct: 236 MWLM---------LQQEQPRD-FCVATGEKHSVREFVEKAFACIGQTVEWKGERGTVEEH 285 Query: 288 ----------FAPR--REGDLPAYWADASKADRELNWRVTRTLDEMAQDTWH 327 PR R ++ D + A+ L W+ + +E+ + Sbjct: 286 GVVDGVVRVRVDPRYFRPTEVDQLLGDPTLAETVLGWKRKVSFEELVRGMVE 337 >2Q1T-A nrPDB Length = 377 Score = 244 bits (622), Expect = 5e-65, Method: Composition-based stats. Identities = 79/344 (22%), Positives = 141/344 (40%), Gaps = 31/344 (9%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNG-HDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 V+V GG+G++GS+ +LL+ G + V ++DNL ++++ +P F E I Sbjct: 34 NVMVVGGAGFVGSNLVKRLLELGVNQVHVVDNLLSAEKINVP-----DHPAVRFSETSIT 88 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMR-AANVKNF 119 ++AL+ + ++ D V H A S+ PL ++NN TL+L ++ +K Sbjct: 89 DDALLASLQDEY--DYVFHLATYHGNQSSIHDPLADHENNTLTTLKLYERLKHFKRLKKV 146 Query: 120 IFSSSAT-----VYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIAL 174 ++S++ + D + SPY SK+ E + Q Sbjct: 147 VYSAAGCSIAEKTFDDAKATEETDIVSLHNNDSPYSMSKIFGE-FYSVYYHKQHQLPTVR 205 Query: 175 LRYFNPVGAHP---SGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGT-GV 230 R+ N G +G P + N+ P A + G P E+G Sbjct: 206 ARFQNVYGPGEILGAGRWRGTPATVWRNVTPTFIYKA--------LKGMPLPLENGGVAT 257 Query: 231 RDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAP 290 RD+I V D+A+G + A+ +YN+ +G S+ D+ ++ G P Sbjct: 258 RDFIFVEDVANGLIACA---ADGTPGGVYNIASGKETSIADLATKINEITGNNTELDRLP 314 Query: 291 RREGDLPA-YWADASKADRELNWRVTRTLDEMAQDTWHWQSRHP 333 +R D + KA REL + ++D+ + T W + Sbjct: 315 KRPWDNSGKRFGSPEKARRELGFSADVSIDDGLRKTIEWTKANL 358 >2Z95-A nrPDB Length = 345 Score = 243 bits (621), Expect = 6e-65, Method: Composition-based stats. Identities = 79/345 (22%), Positives = 143/345 (41%), Gaps = 36/345 (10%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKH-PTFVEGDIR 60 R L+TG G G++ LL+ G++V D S ++ LG ++ + D+ Sbjct: 5 RALITGIRGQDGAYLAKLLLEKGYEVYGADRRSGEFASW--RLKELGIENDVKIIHMDLL 62 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVK-NF 119 + + + D V + A VG S ++P+ + + G LR++ A+R F Sbjct: 63 EFSNIIRTIEKVQPDEVYNLAAQSFVGVSFEQPILTAEVDAIGVLRILEALRTVKPDTKF 122 Query: 120 IFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFN 179 +S++ ++G +IP E P P+SPY +KL I + ++A ++ + + FN Sbjct: 123 YQASTSEMFGKVQEIPQTEKTPF-YPRSPYAVAKLFGHWITVNYREAYNMFACSGI-LFN 180 Query: 180 PVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDL 239 H S G + + + +A++ G +D L + GN D +Y+ M L Sbjct: 181 ----HESPLRG--IEFVTRKITYSLARIKYGLQDKLVL-GNLNAKRDWGYAPEYVEAMWL 233 Query: 240 A------DGHVVA----------MEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKP 283 D +V+A +EK A G I +G G+ +D + GK Sbjct: 234 MMQQPEPDDYVIATGETHTVREFVEKAAKIAGFDIEWVGEGINEKGID------RNTGKV 287 Query: 284 -VNYHFAPRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWH 327 V R ++ + KA ++L W+ T DE+ + Sbjct: 288 IVEVSEEFFRPAEVDILVGNPEKAMKKLGWKPRTTFDELVEIMME 332 >2PK3-A nrPDB Length = 321 Score = 239 bits (609), Expect = 2e-63, Method: Composition-based stats. Identities = 71/335 (21%), Positives = 129/335 (38%), Gaps = 31/335 (9%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 MR L+TG +G++G + L + +V + + LP +E + DI Sbjct: 13 MRALITGVAGFVGKYLANHLTEQNVEVFG---TSRNNEAKLPNVE--------MISLDIM 61 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVK-NF 119 + + +++ D D + H A +V +S + NV GTL ++ A+R +N+ Sbjct: 62 DSQRVKKVISDIKPDYIFHLAAKSSVKDSWLNKKGTFSTNVFGTLHVLDAVRDSNLDCRI 121 Query: 120 IFSSSATVYGD-QPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYF 178 + S+ YG P+ V P SPYG SK V + KA I R F Sbjct: 122 LTIGSSEEYGMILPEESPVSEENQLRPMSPYGVSKASVGMLARQYVKAY-GMDIIHTRTF 180 Query: 179 NPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMD 238 N +G G+ + + I + + +++ + GN D T VRD + Sbjct: 181 NHIGP------GQSLGFVTQDFAKQIVDIEMEKQEPIIKVGNLEAVRDFTDVRDIVQAYW 234 Query: 239 LADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAP--RREGDL 296 L + K G +YN+ +G+G + DV++ ++ P R ++ Sbjct: 235 LLSQY--------GKTG-DVYNVCSGIGTRIQDVLDLLLAMANVKIDTELNPLQLRPSEV 285 Query: 297 PAYWADASKADRELNWRVTRTLDEMAQDTWHWQSR 331 P + W+ L++ + + Sbjct: 286 PTLIGSNKRLKDSTGWKPRIPLEKSLFEILQSYRQ 320 >1RKX-A nrPDB Length = 357 Score = 235 bits (599), Expect = 2e-62, Method: Composition-based stats. Identities = 81/349 (23%), Positives = 132/349 (37%), Gaps = 35/349 (10%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 RV VTG +G+ G + L G V + S+ G GDIR+ Sbjct: 11 RVFVTGHTGFKGGWLSLWLQTMGATVKGYSLTAPTVPSLFETARVADGMQSEI--GDIRD 68 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMR-AANVKNFI 120 + + E + + + V H A V S +P+E Y NV GT+ L+ A+R VK + Sbjct: 69 QNKLLESIREFQPEIVFHMAAQPLVRLSYSEPVETYSTNVMGTVYLLEAIRHVGGVKAVV 128 Query: 121 FSSSATVYGDQPKI-PYVESFPTGTPQSPYGKSKLMVEQILTDLQKA--------QPDWS 171 +S Y ++ I Y E+ G PY SK E + + + + Q + Sbjct: 129 NITSDKCYDNKEWIWGYRENEAMGG-YDPYSNSKGCAELVTSSYRNSFFNPANYGQHGTA 187 Query: 172 IALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVR 231 +A +R N +G GD D + +P+ L + V R+ AI R Sbjct: 188 VATVRAGNVIGG---GDWALD-RIVPDILRAFEQSQPVIIRNPHAI-------------R 230 Query: 232 DYIHVMDLADGHVVAMEKLANKPGVHI--YNLGAG--VGNSVLDVVNAFSKACGKPVNYH 287 + HV++ G+++ +KL + +N G V ++V K G+ ++ Sbjct: 231 PWQHVLEPLSGYLLLAQKLYTDGAEYAEGWNFGPNDADATPVKNIVEQMVKYWGEGASWQ 290 Query: 288 FAPRREGDLPAYW-ADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQG 335 Y D SKA +L W L+ + W G Sbjct: 291 LDGNAHPHEAHYLKLDCSKAKMQLGWHPRWNLNTTLEYIVGWHKNWLSG 339 >2PZM-A nrPDB Length = 330 Score = 232 bits (592), Expect = 2e-61, Method: Composition-based stats. Identities = 77/337 (22%), Positives = 135/337 (40%), Gaps = 46/337 (13%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 MR+L+TGG+G +GS+ L GH+++++DN KR VLP + L + +EG + Sbjct: 21 MRILITGGAGCLGSNLIEHWLPQGHEILVIDNFATGKREVLPPVAGL-----SVIEGSVT 75 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYD---NNVNGTLRLISAMRAANVK 117 + L+ V+H A + + P ++ + NV G++ + A A VK Sbjct: 76 DAGLLERAFDSFKPTHVVHSAA------AYKDPDDWAEDAATNVQGSINVAKAASKAGVK 129 Query: 118 NFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRY 177 + +A YG +P PT P + YG SK E L D + LR Sbjct: 130 RLLNFQTALCYGRPATVPIPIDSPTA-PFTSYGISKTAGEAFLM-----MSDVPVVSLRL 183 Query: 178 FNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVM 237 N G P+ + + ++ G++ F +D VRD++ Sbjct: 184 ANVTG----------PRLAIGPIPTFYKRLKAGQK----CFCSDT-------VRDFL--- 219 Query: 238 DLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPV--NYHFAPRREGD 295 D++D +A L ++N+ G G+S+ +V + G + D Sbjct: 220 DMSDFLAIADLSLQEGRPTGVFNVSTGEGHSIKEVFDVVLDYVGATLAEPVPVVAPGADD 279 Query: 296 LPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRH 332 +P+ D SK + E W+ + W ++ Sbjct: 280 VPSVVLDPSKTETEFGWKAKVDFKDTITGQLAWYDKY 316 >2C54-A nrPDB Length = 379 Score = 228 bits (581), Expect = 3e-60, Method: Composition-based stats. Identities = 71/342 (20%), Positives = 125/342 (36%), Gaps = 40/342 (11%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 +++ +TG G+I SH +L GH VI D N + E + V+ + Sbjct: 30 LKISITGAGGFIASHIARRLKHEGHYVIASDWKKNEH-----MTEDMFCDEFHLVDLRVM 84 Query: 61 NEALMTEILHDHAIDTVIHFAGL---KAVGESVQKPLEYYDNNVNGTLRLISAMRAANVK 117 L +D V + A +S + Y NN + +I A R +K Sbjct: 85 ENCLKVT----EGVDHVFNLAADMGGMGFIQSNHSVIMY--NNTMISFNMIEAARINGIK 138 Query: 118 NFIFSSSATVYGDQPKIPYV-------ESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDW 170 F ++SSA +Y + ++ +++P PQ YG +L E++ K Sbjct: 139 RFFYASSACIYPEFKQLETTNVSLKESDAWP-AEPQDAYGLERLATEELCKHYNK-DFGI 196 Query: 171 SIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGV 230 + R+ N G P G + P + A D ++G DG Sbjct: 197 ECRIGRFHNIYG--PFGTWKGGREKAP----AAFCRKAQTSTDRFEMWG------DGLQT 244 Query: 231 RDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAP 290 R + + + +G V+ + K + V N+G+ S+ ++ K + H P Sbjct: 245 RSFTFIDECVEG-VLRLTKSDFREPV---NIGSDEMVSMNEMAEMVLSFEEKKLPIHHIP 300 Query: 291 RREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRH 332 EG + +D + +L W L E + T+ W Sbjct: 301 GPEG-VRGRNSDNNLIKEKLGWAPNMRLKEGLRITYFWIKEQ 341 >1WVG-A nrPDB Length = 359 Score = 224 bits (571), Expect = 4e-59, Method: Composition-based stats. Identities = 77/349 (22%), Positives = 135/349 (38%), Gaps = 35/349 (10%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 RV VTG +G+ GS + L + G V + S+ ++ GDIR+ Sbjct: 11 RVFVTGHTGFKGSWLSLWLTEMGAIVKGYALDAPTVPSLFEIVRLNDLMESHI--GDIRD 68 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRA-ANVKNFI 120 + + + + V H A V S ++P++ Y NV GT+ L+ ++ N+K + Sbjct: 69 FEKLRSSIAEFKPEIVFHMAAQPLVRLSYEQPIKTYSTNVMGTVHLLETVKQVGNIKAVV 128 Query: 121 FSSSATVYGDQPKI-PYVESFPTGTPQSPYGKSKLMVEQILTDLQKA--------QPDWS 171 +S Y ++ + Y E+ P G PY SK E + + + + Q Sbjct: 129 NITSDKCYDNREWVWGYRENEPMGG-YDPYSNSKGCAELVASAFRNSFFNPANYEQHGVG 187 Query: 172 IALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVR 231 +A +R N +G GD +D + IP+ L + V R+ +I R Sbjct: 188 LASVRAGNVIGG---GDWAKD-RLIPDILRSFENNQQVIIRNPYSI-------------R 230 Query: 232 DYIHVMDLADGHVVAMEKLANKPG--VHIYNLGAGVG--NSVLDVVNAFSKACGKPVNYH 287 + HV++ G++V ++L + +N G +V +V+ G ++ Sbjct: 231 PWQHVLEPLSGYIVVAQRLYTEGAKFSEGWNFGPRDEDAKTVEFIVDKMVTLWGDDASWL 290 Query: 288 FAPRREGDLPAYW-ADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQG 335 Y D SKA+ +L W L E W +G Sbjct: 291 LDGENHPHEAHYLKLDCSKANMQLGWHPRWGLTETLSRIVKWHKAWIRG 339 >2Q1W-A nrPDB Length = 333 Score = 216 bits (551), Expect = 7e-57, Method: Composition-based stats. Identities = 80/338 (23%), Positives = 135/338 (39%), Gaps = 49/338 (14%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 +V +TG G IGSH LL+ G V+ +DN +R L + TFVEG I + Sbjct: 23 KVFITGICGQIGSHIAELLLERGDKVVGIDNFATGRREHLK-----DHPNLTFVEGSIAD 77 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYD---NNVNGTLRLISAMRAANVKN 118 AL+ +++ D D V+H A S + P ++Y+ N G ++ A + NV Sbjct: 78 HALVNQLIGDLQPDAVVHTAA------SYKDPDDWYNDTLTNCVGGSNVVQAAKKNNVGR 131 Query: 119 FIFSSSATVYGDQP-KIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRY 177 F++ +A YG +P + P P S Y SK E L R Sbjct: 132 FVYFQTALCYGVKPIQQPVRLDHPRNPANSSYAISKSANEDYLE-----YSGLDFVTFRL 186 Query: 178 FNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVM 237 N VG P+ + L + +++ G++ + RD++ V Sbjct: 187 ANVVG----------PRNVSGPLPIFFQRLSEGKKCFVT-----------KARRDFVFVK 225 Query: 238 DLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREG--D 295 DLA V A++ + G Y+ +G ++ ++ +A +A P R G D Sbjct: 226 DLARATVRAVDGV----GHGAYHFSSGTDVAIKELYDAVVEAMALPSYPEPEIRELGPDD 281 Query: 296 LPAYWADASKADRELNWRVTRT-LDEMAQDTWHWQSRH 332 P+ D S+ ++ ++ T L E + + Sbjct: 282 APSILLDPSRTIQDFG-KIEFTPLKETVAAAVAYFREY 318 >1N7G-A nrPDB Length = 381 Score = 211 bits (536), Expect = 4e-55, Method: Composition-based stats. Identities = 67/338 (19%), Positives = 125/338 (36%), Gaps = 34/338 (10%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPT-----FVEGD 58 L+TG +G GS+ LL G++V L ++ + + + D Sbjct: 32 LITGITGQDGSYLTEFLLGKGYEVHGLIRRSSNFNTQRINHIYIDPHNVNKALMKLHYAD 91 Query: 59 IRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVK- 117 + + + + + D V + A V S + P D G LRL+ A+R+ + Sbjct: 92 LTDASSLRRWIDVIKPDEVYNLAAQSHVAVSFEIPDYTADVVATGALRLLEAVRSHTIDS 151 Query: 118 ----NFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIA 173 + + S+ ++G P P E+ P P+SPY SK + ++A ++ Sbjct: 152 GRTVKYYQAGSSEMFGSTP-PPQSETTPFH-PRSPYAASKCAAHWYTVNYREAYGLFACN 209 Query: 174 LLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDY 233 + FN H S GE+ + + + ++ VG + L + GN + D DY Sbjct: 210 GI-LFN----HESPRRGEN--FVTRKITRALGRIKVGLQTKLFL-GNLQASRDWGFAGDY 261 Query: 234 IHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKP----VNYHFA 289 + M L + Y + G++V + ++ G V Sbjct: 262 VEAMWLM----------LQQEKPDDYVVATEEGHTVEEFLDVSFGYLGLNWKDYVEIDQR 311 Query: 290 PRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWH 327 R ++ DASKA L W+ +++ + Sbjct: 312 YFRPAEVDNLQGDASKAKEVLGWKPQVGFEKLVKMMVD 349 >3M2P-A nrPDB Length = 311 Score = 199 bits (505), Expect = 2e-51, Method: Composition-based stats. Identities = 67/325 (20%), Positives = 131/325 (40%), Gaps = 40/325 (12%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 +++ VTGG+G++G + + +G+ IIL +G K E + Sbjct: 3 LKIAVTGGTGFLGQYVVESIKNDGNTPIIL-------------TRSIGNKAINDYEYRVS 49 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120 + L I + +D V+H A + S K E++DN + T L A N+ N + Sbjct: 50 DYTLEDLINQLNDVDAVVHLAATRG---SQGKISEFHDNEIL-TQNLYDACYENNISNIV 105 Query: 121 FSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNP 180 ++S+ + Y D+ +P+ E P YG SKL E I ++ + I LR+ + Sbjct: 106 YASTISAYSDETSLPWNEK-ELPLPDLMYGVSKLACEHI-GNIYSRKKGLCIKNLRFAHL 163 Query: 181 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA 240 G + + + + Q G + +L + R++++ D A Sbjct: 164 YGFNEKNNY---------MINRFFRQAFHGEQLTLH--------ANSVAKREFLYAKDAA 206 Query: 241 DGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFA-PRREGDLPAY 299 + A+++ + +N+G+G + +V N + A G N P + + Sbjct: 207 KSVIYALKQ---EKVSGTFNIGSGDALTNYEVANTINNAFGNKDNLLVKNPNANEGIHSS 263 Query: 300 WADASKADRELNWRVTRTLDEMAQD 324 + D+SKA L++ ++ Sbjct: 264 YMDSSKAKELLDFSTDYNFATAVEE 288 >1RPN-A nrPDB Length = 335 Score = 198 bits (502), Expect = 4e-51, Method: Composition-based stats. Identities = 69/329 (20%), Positives = 130/329 (39%), Gaps = 25/329 (7%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 LVTG +G G++ LL+ G+ V L +S + G + +GD+ + Sbjct: 18 LVTGITGQDGAYLAKLLLEKGYRVHGLVARRSSDTRWRLRELGIEGD-IQYEDGDMADAC 76 Query: 64 LMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVK-NFIFS 122 + + V + A VG S +P+ + G L+ A+R + + F + Sbjct: 77 SVQRAVIKAQPQEVYNLAAQSFVGASWNQPVTTGVVDGLGVTHLLEAIRQFSPETRFYQA 136 Query: 123 SSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNPVG 182 S++ ++G E+ P P+SPYG +KL I + +++ + + + FN Sbjct: 137 STSEMFGLIQAERQDENTPF-YPRSPYGVAKLYGHWITVNYRESFGLHASSGI-LFN--- 191 Query: 183 AHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLADG 242 H S G + + + +A++ +G++ L + GN D DY+ M L Sbjct: 192 -HESPLRG--IEFVTRKVTDAVARIKLGKQQELRL-GNVDAKRDWGFAGDYVEAMWLM-- 245 Query: 243 HVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKP----VNYHFAPRREGDLPA 298 + Y + GV +V D+ + G + A R ++ Sbjct: 246 --------LQQDKADDYVVATGVTTTVRDMCQIAFEHVGLDYRDFLKIDPAFFRPAEVDV 297 Query: 299 YWADASKADRELNWRVTRTLDEMAQDTWH 327 + +KA R L W+ +LDE+ + Sbjct: 298 LLGNPAKAQRVLGWKPRTSLDELIRMMVE 326 >4EJ0-A nrPDB Length = 342 Score = 196 bits (497), Expect = 2e-50, Method: Composition-based stats. Identities = 81/354 (22%), Positives = 131/354 (37%), Gaps = 55/354 (15%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHD-VIILDNLCNSKRSVLPVIERLGGKHPTFVEGDI 59 M ++VTG +G+IG++ L + G +I +DNL + K V+ +I Sbjct: 13 MTLIVTGAAGFIGANLVKALNERGETRIIAVDNLTRA------------DKFKNLVDCEI 60 Query: 60 RNEALMTEILHDH------AIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRA 113 + TE + + V H E+ + + DNN + ++ A A Sbjct: 61 DDYLDKTEFVERFARGDFGKVRAVFHEGACSDTMETDGRYM--MDNNFRYSRAVLDACLA 118 Query: 114 ANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIA 173 + F+++SSA +YG + +VE P + YG SK + +Q++ + IA Sbjct: 119 QGAQ-FLYASSAAIYGGSSR--FVEEREVEAPLNVYGYSKFLFDQVIRRVMPGAKS-QIA 174 Query: 174 LLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDY 233 RYFN G S G +N + A+ + +FG G RD+ Sbjct: 175 GFRYFNVYGPRES-HKGRMASVAFHNFNQFRAE------GKVKLFGEYSGYGPGEQTRDF 227 Query: 234 IHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLD----VVNAFSKACGKP------ 283 + V D+A ++ + I+NLG G D VVN G+P Sbjct: 228 VSVEDVAKVNLYFFDHPEK---SGIFNLGTGRAQPFNDIAATVVNTLRALEGQPALTLAE 284 Query: 284 ------VNYHFAPR--REGDLPAYWADASKADRELNWR-VTRTLDEMAQDTWHW 328 V Y P R AD +K R + T+ E W Sbjct: 285 QVEQGLVEYVPFPDALRGKYQCFTQADQTKL-RAAGYDAPFLTVQEGVDRYVRW 337 >3SXP-A nrPDB Length = 362 Score = 192 bits (487), Expect = 2e-49, Method: Composition-based stats. Identities = 78/331 (23%), Positives = 134/331 (40%), Gaps = 36/331 (10%) Query: 3 VLVTGGSGYIGSHTCVQLLQN--GHDVIILDN------LCNSKRSVLPVIERLGGKHPTF 54 +L+TGG+G++GS+ +N V++LD N++ S L + L G Sbjct: 13 ILITGGAGFVGSNLAFHFQENHPKAKVVVLDKFRSNTLFSNNRPSSLGHFKNLIGFKGEV 72 Query: 55 VEGDIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAA 114 + DI N + + H D + H A + ++ N L L+ R+ Sbjct: 73 IAADINNPLDLRRLEKLH-FDYLFHQAAVS--DTTMLNQELVMKTNYQAFLNLLEIARSK 129 Query: 115 NVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIAL 174 K I++SSA VYG+ K P V +P++ YG SKL +++ + + + + Sbjct: 130 KAK-VIYASSAGVYGN-TKAPNVVGKN-ESPENVYGFSKLCMDEFVLS--HSNDNVQV-G 183 Query: 175 LRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYI 234 LRYFN G + Q+A+G F E G +RD++ Sbjct: 184 LRYFNVYGPRE---------FYKEKTASMVLQLALG----AMAFKEVKLFEFGEQLRDFV 230 Query: 235 HVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGK-PVNYHFAPRRE 293 ++ D+ +V AM+ A K G +YN+G S ++V+ + G V Y P Sbjct: 231 YIEDVIQANVKAMK--AQKSG--VYNVGYSQARSYNEIVSILKEHLGDFKVTYIKNPYA- 285 Query: 294 GDLPAYWADASKADRELNWRVTRTLDEMAQD 324 A +L++ L+ +D Sbjct: 286 FFQKHTQAHIEPTILDLDYTPLYDLESGIKD 316 >4WKG-A nrPDB Length = 660 Score = 185 bits (470), Expect = 2e-47, Method: Composition-based stats. Identities = 73/353 (20%), Positives = 125/353 (35%), Gaps = 41/353 (11%) Query: 2 RVLVTGGSGYIGSHTCVQLL-QNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 RVL+ G +G+IG+H +LL ++ ++V LD ++ + L H FVEGDI Sbjct: 317 RVLILGVNGFIGNHLTERLLREDHYEVYGLDIGSDA------ISRFLNHPHFHFVEGDIS 370 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120 + E H D V+ + E + PL ++ + LR+I K I Sbjct: 371 IHSEWIE-YHVKKCDVVLPLVAIATPIEYTRNPLRVFELDFEENLRIIRYCVKYR-KRII 428 Query: 121 FSSSATVYGDQPKIPYVESF------PTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIAL 174 F S++ VYG + E P P+ Y SK ++++++ + + L Sbjct: 429 FPSTSEVYGMCSDKYFDEDHSNLIVGPVNKPRWIYSVSKQLLDRVIWAYGEKE-GLQFTL 487 Query: 175 LRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYI 234 R FN +G G + I + G L + G R + Sbjct: 488 FRPFNWMGPRLDNLNAARI-GSSRAITQLILNLVEGSPIKL--------IDGGKQKRCFT 538 Query: 235 HVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNY-HFAPRRE 293 + D + +E N+ I N+G + ++ + A + H P Sbjct: 539 DIRDGIEALYRIIENAGNRCDGEIINIGNPENEASIEELGEMLLASFEKHPLRHHFPPFA 598 Query: 294 G---------------DLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSR 331 G D+ A R L+W + E +T + R Sbjct: 599 GFRVVESSSYYGKGYQDVEHRKPSIRNAHRCLDWEPKIDMQETIDETLDFFLR 651 >1EQ2-A nrPDB Length = 310 Score = 176 bits (446), Expect = 1e-44, Method: Composition-based stats. Identities = 73/342 (21%), Positives = 134/342 (39%), Gaps = 48/342 (14%) Query: 3 VLVTGGSGYIGSHTCVQLLQNG-HDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 ++VTGG+G+IGS+ L G D++++DNL + K V+ +I + Sbjct: 2 IIVTGGAGFIGSNIVKALNDKGITDILVVDNLKDGT------------KFVNLVDLNIAD 49 Query: 62 EALMTEIL-------HDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAA 114 + L ++ + H + E K + DNN + L+ Sbjct: 50 YMDKEDFLIQIMAGEEFGDVEAIFHEGACSSTTEWDGKYM--MDNNYQYSKELLHYCLER 107 Query: 115 NVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIAL 174 + F+++SSA YG + ++ES P + YG SK + ++ + + + + I Sbjct: 108 EIP-FLYASSAATYGGRTS-DFIESREYEKPLNVYGYSKFLFDEYVRQIL-PEANSQIVG 164 Query: 175 LRYFNPVGAHPSGDMGEDPQGIPNNLMPYI-AQVAVGRRDSLAIFGNDYPTEDGTGVRDY 233 RYFN G E +G ++ ++ Q+ G L ++ RD+ Sbjct: 165 FRYFNVYGPR------EGHKGSMASVAFHLNTQLNNGESPKLFEGSENFK-------RDF 211 Query: 234 IHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRRE 293 ++V D+AD ++ +E I+NLG G S V +A K + P + Sbjct: 212 VYVGDVADVNLWFLEN----GVSGIFNLGTGRAESFQAVADATLAYH-KKGQIEYIPFPD 266 Query: 294 GDLPAYWADASKADREL---NW-RVTRTLDEMAQDTWHWQSR 331 Y A L + + +T+ E + W +R Sbjct: 267 KLKGRYQAFTQADLTNLRAAGYDKPFKTVAEGVTEYMAWLNR 308 >2X86-A nrPDB Length = 357 Score = 175 bits (443), Expect = 3e-44, Method: Composition-based stats. Identities = 72/342 (21%), Positives = 134/342 (39%), Gaps = 48/342 (14%) Query: 3 VLVTGGSGYIGSHTCVQLLQNG-HDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 ++VTGG+G+IGS+ L G D++++DNL + K V+ +I + Sbjct: 49 IIVTGGAGFIGSNIVKALNDKGITDILVVDNLKDGT------------KFVNLVDLNIAD 96 Query: 62 EALMTEIL-------HDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAA 114 + L ++ + H + E K + DNN + L+ Sbjct: 97 YMDKEDFLIQIMAGEEFGDVEAIFHEGACSSTTEWDGKYM--MDNNYQYSKELLHYCLER 154 Query: 115 NVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIAL 174 + F+++SSA YG + ++ES P + +G SK + ++ + + + + I Sbjct: 155 EIP-FLYASSAATYGGRTS-DFIESREYEKPLNVFGYSKFLFDEYVRQIL-PEANSQIVG 211 Query: 175 LRYFNPVGAHPSGDMGEDPQGIPNNLMPYI-AQVAVGRRDSLAIFGNDYPTEDGTGVRDY 233 RYFN G E +G ++ ++ Q+ G L ++ RD+ Sbjct: 212 FRYFNVYGPR------EGHKGSMASVAFHLNTQLNNGESPKLFEGSENFK-------RDF 258 Query: 234 IHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRRE 293 ++V D+AD ++ +E I+NLG G S V +A K + P + Sbjct: 259 VYVGDVADVNLWFLEN----GVSGIFNLGTGRAESFQAVADATLAYH-KKGQIEYIPFPD 313 Query: 294 GDLPAYWADASKADREL---NW-RVTRTLDEMAQDTWHWQSR 331 Y A L + + +T+ E + W +R Sbjct: 314 KLKGRYQAFTQADLTNLRAAGYDKPFKTVAEGVTEYMAWLNR 355 >2GN9-A nrPDB Length = 344 Score = 134 bits (336), Expect = 6e-32, Method: Composition-based stats. Identities = 59/308 (19%), Positives = 105/308 (34%), Gaps = 56/308 (18%) Query: 3 VLVTGGSGYIGSHTCVQLLQ--NGHDVIIL--DNLCNSKRSVLPVIERLGGKHPTFVEGD 58 +L+TGG+G G ++L N +I+ D L S+ ++ F GD Sbjct: 24 ILITGGTGSFGKCFVRKVLDTTNAKKIIVYSRDELKQSEMAM-----EFNDPRMRFFIGD 78 Query: 59 IRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKN 118 +R+ + L +D IH A LK V + PLE N+ G +I+A + Sbjct: 79 VRDLERLNYALE--GVDICIHAAALKHVPIAEYNPLECIKTNIMGASNVINACLKNAISQ 136 Query: 119 FIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQ--KAQPDWSIALLR 176 I S+ P + YG +KL +++ K +++R Sbjct: 137 VIALSTDK---------------AANPINLYGATKLCSDKLFVSANNFKGSSQTQFSVVR 181 Query: 177 YFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHV 236 Y N VG+ S ++P+ ++ + + I D R +I + Sbjct: 182 YGNVVGSRGS-------------VVPFFKKLVQNKASEIPI-------TDIRMTRFWITL 221 Query: 237 MDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDL 296 + G ++ L G I+ + + D+ KA R G+ Sbjct: 222 DE---GVSFVLKSLKRMHGGEIF-VPKIPSMKMTDLA----KALAPNTPTKIIGIRPGEK 273 Query: 297 PAYWADAS 304 Sbjct: 274 LHEVMIPK 281 >1GFS-A nrPDB Length = 321 Score = 132 bits (331), Expect = 3e-31, Method: Composition-based stats. Identities = 62/346 (17%), Positives = 118/346 (34%), Gaps = 42/346 (12%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 RV + G G +GS QL Q G ++L T E ++ + Sbjct: 5 RVFIAGHRGMVGSAIRRQLEQRGDVELVLR---------------------TRDELNLLD 43 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQK-PLEYYDNNVNGTLRLISAMRAANVKNFI 120 + + ID V A + P ++ N+ +I A +V + Sbjct: 44 SRAVHDFFASERIDQVYLAAAKVGGIVANNTYPADFIYQNMMIESNIIHAAHQNDVNKLL 103 Query: 121 FSSSATVYGDQPKIPYVESFPTGT---PQS-PYGKSKLMVEQILTDLQKAQPDWSIALLR 176 F S+ +Y K P ES P + PY +K+ ++ + + Sbjct: 104 FLGSSCIYPKLAKQPMAESELLQGTLEPTNEPYAIAKIAGIKLCESYNRQY-GRDYRSVM 162 Query: 177 YFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHV 236 N G H + + L+ + + ++G+ GT +R+++HV Sbjct: 163 PTNLYGPHDNFH--PSNSHVIPALLRRFHEATAQNAPDVVVWGS------GTPMREFLHV 214 Query: 237 MDLADGHVVAMEKLAN------KPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAP 290 D+A + ME +P + N+G GV ++ ++ +K G F Sbjct: 215 DDMAAASIHVMELAHEVWLENTQPMLSHINVGTGVDCTIRELAQTIAKVVGYKGRVVFDA 274 Query: 291 RREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGY 336 + P D ++ + L W +L+ T+ W + + Sbjct: 275 SKPDGTPRKLLDVTRLHQ-LGWYHEISLEAGLASTYQWFLENQDRF 319 >4BKP-A nrPDB Length = 336 Score = 109 bits (273), Expect = 1e-24, Method: Composition-based stats. Identities = 58/340 (17%), Positives = 126/340 (37%), Gaps = 40/340 (11%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 MR+LVTGGSG +G +++ +G + D + S + + D+ Sbjct: 23 MRILVTGGSGLVGKAI-QKVVADGAGLPGEDWVFVSSK-----------------DADLT 64 Query: 61 NEALMTEILHDHAIDTVIHFAGL-KAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNF 119 + A + VIH A + + +++ L+++ NV+ ++ + + Sbjct: 65 DTAQTRALFEKVQPTHVIHLAAMVGGLFRNIKYNLDFWRKNVHMNDNVLHSAFEVGARKV 124 Query: 120 IFSSSATVYGDQPKIPYVESF-PTGTPQSP---YGKSKLMVEQILTDLQKAQPDWSIALL 175 + S ++ D+ P E+ G P + Y +K M++ + A++ Sbjct: 125 VSCLSTCIFPDKTTYPIDETMIHNGPPHNSNFGYSYAKRMIDVQNRAYFQQYGCTFTAVI 184 Query: 176 RYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIH 235 N G H + ++ ED +P + + +A +L ++G G R +I+ Sbjct: 185 -PTNVFGPHDNFNI-EDGHVLPGLI--HKVHLAKSSGSALTVWGT------GNPRRQFIY 234 Query: 236 VMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGD 295 +DLA + + + + I ++G S+ + A +A F + Sbjct: 235 SLDLAQLFIWVLREYNEVEPI-ILSVGEEDEVSIKEAAEAVVEAMDFHGEVTFDTTKSDG 293 Query: 296 LPAYWADASKADR---ELNWRVTRTLDEMAQDTWHWQSRH 332 A SK + + + ++T W + + Sbjct: 294 QFKKTASNSKLRTYLPDFRFTP---FKQAVKETCAWFTDN 330 >4G5H-A nrPDB Length = 363 Score = 109 bits (272), Expect = 2e-24, Method: Composition-based stats. Identities = 53/295 (17%), Positives = 96/295 (32%), Gaps = 46/295 (15%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 +L+TGG+G G+ + L + I + ++ + ++ F GD+R+ Sbjct: 28 LLITGGTGSFGNAVMKRFLDSNIKEIRI--FSRDEKKQDDIRKKYNNSKLKFYIGDVRDS 85 Query: 63 ALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFS 122 + + D +D V H A LK V P+E N+ GT ++ + NVK I Sbjct: 86 QSVETAMRD--VDYVFHAAALKQVPSCEFFPVEAVKTNIIGTENVLQSAIHQNVKKVICL 143 Query: 123 SSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQK--AQPDWSIALLRYFNP 180 S+ P + G SK M+E++ + I RY N Sbjct: 144 STDK---------------AAYPINAMGISKAMMEKVFVAKSRNIRSEQTLICGTRYGNV 188 Query: 181 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA 240 + + S ++P G D R + + D Sbjct: 189 MASRGS-------------VIPLFIDK--------IKAGEPLTITDPDMTRFLMSLEDAV 227 Query: 241 DGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGD 295 + V A + + + ++V D+ A + R G+ Sbjct: 228 ELVVHAFKHAETGDIM----VQKAPSSTVGDLATALLELFEADNAIEIIGTRHGE 278 >3WMX-A nrPDB Length = 358 Score = 107 bits (268), Expect = 5e-24, Method: Composition-based stats. Identities = 64/332 (19%), Positives = 108/332 (32%), Gaps = 36/332 (10%) Query: 2 RVLVTGGSGYIGSHTCVQLLQN-GHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 ++L+ G +G IGS + L + G +I ++ + R V E L Sbjct: 27 KILIVGANGQIGSELALALAERYGRTNVITSDVVPTGRHVHLTHEMLNA----------T 76 Query: 61 NEALMTEILHDHAIDTVIHFAG-LKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNF 119 + + ++ H I V A L A GE + P ++ N+ L ++ R ++ Sbjct: 77 DRGELATVVERHGITQVYLLAAALSATGE--KAPQWAWNLNMTSLLNVLELARQTGLERV 134 Query: 120 IFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFN 179 + SS +G P + YG SK E A + +RY Sbjct: 135 FWPSSIAAFGPTTPAGQTPQKTVMEPTTVYGISKQAGEGWCRWY-HANHGVDVRSVRYPG 193 Query: 180 PVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDL 239 + G + I AV D +++ D Sbjct: 194 LISHKTPPGGGTTDYAVD------IFHAAVTGEPYTCFLKEDEALP-------MMYMPDA 240 Query: 240 ADGHVVAMEKLANK-PGVHIYNLGAGVGNSVLDVVNAFSK-ACGKPVNYHFAPR---REG 294 + ME A+K YN+ AG+ + + A + G + Y R +G Sbjct: 241 IRATIELMEAPADKLSERGSYNI-AGMSFTPAQIAAAIREQVPGFQIRYEPDYRQAIAQG 299 Query: 295 DLPAYWADASKADRELNWRVTRTLDEMAQDTW 326 + D S A + W+ L EM D Sbjct: 300 WPDS--IDDSVARADWGWKAQYGLKEMVADML 329 >4J2O-A nrPDB Length = 363 Score = 106 bits (264), Expect = 2e-23, Method: Composition-based stats. Identities = 52/296 (17%), Positives = 101/296 (34%), Gaps = 47/296 (15%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 +L+TGG+G G+ + L+ D+ + ++ + ++ F GD+R+ Sbjct: 26 LLITGGTGSFGNAVLKRFLE--TDIKEIRIFSRDEKKQDDMRKKYHSAKLKFYIGDVRDY 83 Query: 63 ALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFS 122 + + +D + H A LK V P+E NV GT ++ A +VK + Sbjct: 84 NSI--LNATRGVDYIYHAAALKQVPSCEFHPMEAVKTNVLGTENVLEAAIQNHVKRVVCL 141 Query: 123 SSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWS--IALLRYFNP 180 S+ P + G SK M+E+++ + I RY N Sbjct: 142 STDK---------------AVYPINAMGISKAMMEKVMVAKSRNLEGLDTVICGTRYGNV 186 Query: 181 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA 240 + + S + ++ Q+ G+ D R + + D Sbjct: 187 MASRGS------------VIPLFVDQIRQGK---------PLTITDPNMTRFMMTLEDAV 225 Query: 241 DGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACG-KPVNYHFAPRREGD 295 D + A E N I+ + ++ + A + + R G+ Sbjct: 226 DLVLYAFEHGENG---DIF-VQKAPAATIAVLAEALKQLLNVEDHPISIMGTRHGE 277 >1ZZE-A nrPDB Length = 342 Score = 103 bits (257), Expect = 9e-23, Method: Composition-based stats. Identities = 76/355 (21%), Positives = 121/355 (34%), Gaps = 62/355 (17%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 VLVTG +G++ SH QLL++G+ V S + + +R K+P E Sbjct: 14 VLVTGANGFVASHVVEQLLEHGYKV---RGTARSASKLANLQKRWDAKYPGRFE-----T 65 Query: 63 ALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVN----GTLRLISAMRAA-NVK 117 A++ ++L A D VI A A SV YD V GTL + A A +VK Sbjct: 66 AVVEDMLKQGAYDEVIKGAAGVAHIASVVSFSNKYDEVVTPAIGGTLNALRAAAATPSVK 125 Query: 118 NFIFSSS----------------ATVYGDQPKIPYVESFPTGTPQ---SPYGKSKLMVEQ 158 F+ +SS + I ++ P PQ Y SK E Sbjct: 126 RFVLTSSTVSALIPKPNVEGIYLDEKSWNLESIDKAKTLPESDPQKSLWVYAASKTEAEL 185 Query: 159 ILTDLQKAQPDWSIALLRYFNPVGAHPSGDMGE--DPQGIPNNLMPYIAQVAVGR-RDSL 215 +F P+ +G DP+ + ++ + G +L Sbjct: 186 AAWKFMDENKP-------HFTLNAVLPNYTIGTIFDPETQSGSTSGWMMSLFNGEVSPAL 238 Query: 216 AIFGNDYPTEDGTGVRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNA 275 A+ Y Y+ +D+ H+ + L +Y G V+ Sbjct: 239 ALMPPQY----------YVSAVDIGLLHLGCL-VLPQIERRRVY--GTAGTFDWNTVLAT 285 Query: 276 FSKACGKPVNYHFAPRREGDLPAYWADASK-ADREL---NWRVTRTLDEMAQDTW 326 F K P + DL + S + L WR +++E +D Sbjct: 286 FRKLYPSKTFPADFPDQGQDLSKFDTAPSLEILKSLGRPGWR---SIEESIKDLV 337 >1VL0-A nrPDB Length = 292 Score = 98.3 bits (243), Expect = 4e-21, Method: Composition-based stats. Identities = 42/175 (24%), Positives = 67/175 (38%), Gaps = 24/175 (13%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 M++L+TG +G +G QL +VI D + DI Sbjct: 13 MKILITGANGQLGREIQKQLKGKNVEVIPTD----------------------VQDLDIT 50 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120 N + + ++ + VI+ A AV + ++ Y N G L +A + + + Sbjct: 51 NVLAVNKFFNEKKPNVVINCAAHTAVDKCEEQYDLAYKINAIGPKNLAAAAYSVGAE-IV 109 Query: 121 FSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALL 175 S+ V+ + K P E F PQS YGK+KL E + L A L Sbjct: 110 QISTDYVFDGEAKEPITE-FDEVNPQSAYGKTKLEGENFVKALNPKYYIVRTAWL 163 >6GCS-E nrPDB Length = 375 Score = 98.3 bits (243), Expect = 5e-21, Method: Composition-based stats. Identities = 42/159 (26%), Positives = 70/159 (44%), Gaps = 23/159 (14%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEAL 64 V G +G++GS+ +L ++G V++ +KR L V LG F+E D+RN Sbjct: 58 VFGANGFLGSYLTAKLAKHGTTVVVPYREEMAKRH-LKVTGDLGV--VNFLEMDLRNLES 114 Query: 65 MTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFSSS 124 + E + D V++ G E K YYD +V G R+ A++ N+ +I S+ Sbjct: 115 IDEAVRHS--DIVVNLIG----REYETKNFNYYDVHVEGARRIAEAVKKHNIARYIHVSA 168 Query: 125 ATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDL 163 D P S + +K + EQ+ D+ Sbjct: 169 FNAEIDSP--------------SEFNHTKGLGEQVTKDI 193 >5B6K-A nrPDB Length = 366 Score = 97.1 bits (240), Expect = 9e-21, Method: Composition-based stats. Identities = 61/335 (18%), Positives = 109/335 (32%), Gaps = 39/335 (11%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 V V+G +G+I H QLL + VI + VI + G + V+ DI + Sbjct: 24 VFVSGATGFIAQHVVRQLLDQNYKVIGSVRSAEKGDHLKNVIFKGGDFNYEIVK-DISDP 82 Query: 63 ALMTEILHDHAIDT--VIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAAN---VK 117 + H D V+H A + + VNGT ++ +++ V+ Sbjct: 83 TAFDHVFEKHGKDIKVVLHTASPFHFNTTDIEKDLLIPA-VNGTKGILESIKKYAAQTVE 141 Query: 118 NFIFSSSATV--------YGDQPKIPYVESFPTG--------TPQSPYGKSKLMVEQILT 161 + +SS Y E P Y SK E+ Sbjct: 142 RVVVTSSFAANTSTVDMFYAKDSSKTITEESWNQDTWESCQSDPIRGYCGSKKFAEKAAW 201 Query: 162 DLQKAQPD---WSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIF 218 D A D + ++++ G + G+ + ++ + + + D L F Sbjct: 202 DFYNANKDSVKFKLSIINPVYVFGPQNYVEPGKKILNTSSEVINSLVHLK--KDDPLPEF 259 Query: 219 GNDYPTEDGTGVRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSK 278 G I V D+A H++A +K + + G ++LD++N Sbjct: 260 A-------GGH----IDVRDVAKAHILAFQKDELIEQRLMLHAGLFTTQTLLDIINEQFP 308 Query: 279 ACGKPVNYHFAPRREGDLPAYWADASKADRELNWR 313 + D D SK + L + Sbjct: 309 ELKGKIPAGKPGTGNPDDALTPVDNSKTKKLLGFE 343 >6AQY-A nrPDB Length = 341 Score = 94.8 bits (234), Expect = 4e-20, Method: Composition-based stats. Identities = 55/345 (15%), Positives = 108/345 (31%), Gaps = 51/345 (14%) Query: 3 VLVTGGSGYIGS---HTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDI 59 +LVTGG+G G H + G V LG K +GD+ Sbjct: 27 ILVTGGTGLFGKAVEHIVKKEQIKGKWVF------------------LGSK-----DGDL 63 Query: 60 RNEALMTEILHDHAIDTVIHFAGLKAVGESVQKP-LEYYDNNVNGTLRLISAMRAANVKN 118 R+ + + VIH A + ++ +NVN +++ VK Sbjct: 64 RDADACKQPFEKYRPTYVIHLAAFVGGLFKNMNFKVSFWLDNVNMNNNILTCCYDFGVKK 123 Query: 119 FIFSSSATVYGDQPKIPYVESFPTGTP----QSPYGKSKLMVEQILTDLQKAQPDWS--- 171 I S V+ D+ + P E P + Y +K M++ + + + Sbjct: 124 TISCLSTCVFPDKIEYPITEEKLHEGPPHFSNNAYAYAKRMLDMLGRWYNEKAVNEGKSC 183 Query: 172 -IALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGV 230 + N G H + ++ + + A +FG+ G + Sbjct: 184 LFTSVIPTNLFGPHDNFNVEAGHVL---PGLMHKCYKAQQNGTDFVVFGS------GKPL 234 Query: 231 RDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAP 290 R +++ D A + M ++ + + + S+ V A N F Sbjct: 235 RQFLYSHDAARMLLWTMFNYQSEEPIMLC-VSEEDEKSIGQVAQTIKDAFNFTGNMVFDT 293 Query: 291 RREGDLPAYWADASKADRE---LNWRVTRTLDEMAQDTWHWQSRH 332 + + +K R + ++ ++T W + Sbjct: 294 SKADGQYKKTSSNAKFLRLNPTFQYTP---FEQAIKETVQWFLEN 335 >2P4H-X nrPDB Length = 322 Score = 92.5 bits (228), Expect = 3e-19, Method: Composition-based stats. Identities = 55/339 (16%), Positives = 107/339 (31%), Gaps = 40/339 (11%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGG--KHPTFVEGDI 59 RV VTGG+G++GS LL+NG+ V ++ + + L G + F D+ Sbjct: 3 RVCVTGGTGFLGSWIIKSLLENGYSVNTTIRADPERKRDVSFLTNLPGASEKLHFFNADL 62 Query: 60 RNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAAN-VKN 118 N + + H A S + + V+G L ++ A + VK Sbjct: 63 SNPDSFAAAIE--GCVGIFHTASPIDFAVSEPEEIVTKRT-VDGALGILKACVNSKTVKR 119 Query: 119 FIFSSSAT----------VYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQP 168 FI++SS + V + Y SK + E+ + + + Q Sbjct: 120 FIYTSSGSAVSFNGKDKDVLDESDWSDVDLLRSVKPFGWNYAVSKTLAEKAVLEFGE-QN 178 Query: 169 DWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGT 228 + L +P + ++ + + + G Sbjct: 179 GIDVVTL-------------------ILPFIVGRFVCPKLPDSIEKALVLVLGKKEQIGV 219 Query: 229 GVRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHF 288 +HV D+A H+ +E YN + + ++ S + Sbjct: 220 TRFHMVHVDDVARAHIYLLENSVPGGR---YNCSPFI-VPIEEMSQLLSAKYPEYQILTV 275 Query: 289 APRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWH 327 +E +K + + T+++M D Sbjct: 276 DELKEIKGARLPDLNTKKLVDAGFDFKYTIEDMFDDAIQ 314 >4PVC-A nrPDB Length = 342 Score = 91.7 bits (226), Expect = 4e-19, Method: Composition-based stats. Identities = 76/346 (21%), Positives = 118/346 (34%), Gaps = 36/346 (10%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTF---VEG 57 M V V+G +G+I H LL+ + VI S+ + E G +P F V Sbjct: 1 MSVFVSGANGFIAQHIVDLLLKEDYKVIG---SARSQEKAENLTEAF-GNNPKFSMEVVP 56 Query: 58 DIRNEALMTEILHDHAID--TVIHFAG--LKAVGESVQKPLEYYDNNVNGTLRLISAMRA 113 DI + H D V+H A + +S + L N V G L I A Sbjct: 57 DISKLDAFDHVFQKHGKDIKIVLHTASPFCFDITDSERDLLIPAVNGVKGILHSIKKYAA 116 Query: 114 ANVKNFIFSSS-ATVYGDQPKIP-----YVESFPTGT-------PQSPYGKSKLMVEQIL 160 +V+ + +SS A V+ + ES+ T P + Y SK E+ Sbjct: 117 DSVERVVLTSSYAAVFDMAKENDKSLTFNEESWNPATWESCQSDPVNAYCGSKKFAEKAA 176 Query: 161 TDLQKAQPDWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGN 220 + + D L NPV PQ ++ ++ + + Sbjct: 177 WEFLEENRDSVKFELTAVNPV-------YVFGPQMFDKDVKKHLNTSCELVNSLMHLSPE 229 Query: 221 DYPTEDGTGVRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKAC 280 D E G YI V D+A H+VA +K I + VLD++N Sbjct: 230 DKIPELFGG---YIDVRDVAKAHLVAFQKRETIGQRLIVSEARFTMQDVLDILNEDFPVL 286 Query: 281 GKPVNY-HFAPRREGDLPAYWADASKADRELNWRVTRTLDEMAQDT 325 + + D K+ + L ++ L E DT Sbjct: 287 KGNIPVGKPGSGATHNTLGATLDNKKSKKLLGFKFR-NLKETIDDT 331 >2NNL-D nrPDB Length = 337 Score = 90.6 bits (223), Expect = 9e-19, Method: Composition-based stats. Identities = 62/338 (18%), Positives = 114/338 (33%), Gaps = 41/338 (12%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGK-HPTFVEGDIRN 61 V VTG SG+IGS ++LL+ G+ V + + V +++ + H T + D+ + Sbjct: 8 VCVTGASGFIGSWLVMRLLERGYTVRATVRDPTNVKKVKHLLDLPKAETHLTLWKADLAD 67 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAAN-VKNFI 120 E E + V H ES E + G L ++ + AA V+ + Sbjct: 68 EGSFDEAIK--GCTGVFH-VATPMDFESKDPENEVIKPTIEGMLGIMKSCAAAKTVRRLV 124 Query: 121 FSSSAT----------VYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDW 170 F+SSA VY + Y SK + EQ K + + Sbjct: 125 FTSSAGTVNIQEHQLPVYDESCWSDMEFCRAKKMTAWMYFVSKTLAEQAAWKYAK-ENNI 183 Query: 171 SIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGV 230 + VG I +++ P + I GN+ Sbjct: 184 DFITIIPTLVVGP-----------FIMSSMPPSLITALS------PITGNEAHYSIIRQG 226 Query: 231 RDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGK-PVNYHFA 289 + ++H+ DL + H+ E + + + +LD+ + + + F Sbjct: 227 Q-FVHLDDLCNAHIYLFENPKAEGRY----ICSSHDCIILDLAKMLREKYPEYNIPTEFK 281 Query: 290 PRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWH 327 E +SK +L + +L++M Sbjct: 282 GVDE--NLKSVCFSSKKLTDLGFEFKYSLEDMFTGAVD 317 >4R1T-A nrPDB Length = 337 Score = 88.6 bits (218), Expect = 3e-18, Method: Composition-based stats. Identities = 65/324 (20%), Positives = 111/324 (34%), Gaps = 44/324 (13%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVII-LDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 V VTG G+I S LL+ G+ V + N + K L +E + T + D+ + Sbjct: 13 VCVTGAGGFIASWLVKILLEKGYTVRGTVRNPDDPKNGHLRELEGA-KERLTLCKADLLD 71 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIF 121 + E + + D V H A P + + V GT +I+A ANV+ +F Sbjct: 72 YQSLREAI--NGCDGVFHTASPV-----TDDPEQMVEPAVIGTKNVINAAAEANVRRVVF 124 Query: 122 SSSA-TVYGDQPKIPYV--ESFPTGTPQ------SPYGKSKLMVEQILTDLQKAQPDWSI 172 +SS VY D + P + P + Y K++ EQ + K + + Sbjct: 125 TSSIGAVYMDPNRDPETVVDETCWSDPDFCKNTKNWYCYGKMVAEQAAWEEAK-EKGVDL 183 Query: 173 ALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRD 232 ++ G + I L G+ + Sbjct: 184 VVINPVLVQGPLLQTTVNASVLHILKYLT-----------------GSAKTYANSVQA-- 224 Query: 233 YIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGK-PVNYHFAPR 291 Y+ V D+A H++ + + G + L A DVV SK + P+ + Sbjct: 225 YVDVKDVALAHIL-LYETPEASGRY---LCAESVLHRGDVVEILSKFFPEYPIPTKCSDV 280 Query: 292 REGDLPAYWADASKADRE-LNWRV 314 + + Y K L + Sbjct: 281 TKPRVKPYKFSNQKLKDLGLEFTP 304 >3SC6-A nrPDB Length = 287 Score = 87.9 bits (216), Expect = 6e-18, Method: Composition-based stats. Identities = 38/183 (20%), Positives = 70/183 (38%), Gaps = 28/183 (15%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 RV++TG +G +G +L +D+ D DI N Sbjct: 7 RVIITGANGQLGKQLQEELNPEEYDIYPFDKKL----------------------LDITN 44 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIF 121 + + +++ + +IH A V ++ ++ Y N G + A + K ++ Sbjct: 45 ISQVQQVVQEIRPHIIIHCAAYTKVDQAEKERDLAYVINAIGARNVAVASQLVGAK-LVY 103 Query: 122 SSSATVY-GDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALL--RYF 178 S+ V+ GD+P+ + F P + YG SK EQ + +L + L +Y Sbjct: 104 ISTDYVFQGDRPEGY--DEFHNPAPINIYGASKYAGEQFVKELHNKYFIVRTSWLYGKYG 161 Query: 179 NPV 181 N Sbjct: 162 NNF 164 >4WPG-A nrPDB Length = 289 Score = 87.1 bits (214), Expect = 9e-18, Method: Composition-based stats. Identities = 35/184 (19%), Positives = 65/184 (35%), Gaps = 27/184 (14%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 +L+TG +G +G+ L + G D + +D E DI NE Sbjct: 7 ILITGSNGQLGTELRYLLDERGVDYVAVD----------------------VAEMDITNE 44 Query: 63 ALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDN-NVNGTLRLISAMRAANVKNFIF 121 + + V H A AV + + + NV G+ + A ++ Sbjct: 45 DKVEAVFAQVKPTLVYHCAAYTAVDAAEDEGKALNEAINVTGSENIAKACGKYGAT-LVY 103 Query: 122 SSSATVY-GDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNP 180 S+ V+ G++P P++ YG++K + E + + A + F Sbjct: 104 ISTDYVFDGNKPVGQEWVETDHPDPKTEYGRTKRLGELAVERYAEHFYIIRTAWV--FGN 161 Query: 181 VGAH 184 G + Sbjct: 162 YGKN 165 >4KTT-E nrPDB Length = 327 Score = 85.9 bits (211), Expect = 2e-17, Method: Composition-based stats. Identities = 62/333 (18%), Positives = 101/333 (30%), Gaps = 48/333 (14%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 RVLVTG +G +G + QN + P F + ++ + Sbjct: 23 RVLVTGATGLLGRAVHKEFQQNNWHAVGC---------------GFRRARPKFEQVNLLD 67 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIF 121 + I+HD ++H A + +P NV+ + L A I+ Sbjct: 68 SNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGNLAKEAAAVGAF-LIY 126 Query: 122 SSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNPV 181 SS V+ D PY E P + YGK+KL E+ + + + A+LR Sbjct: 127 ISSDYVF-DGTNPPYREE-DIPAPLNLYGKTKLDGEKAVL-----ENNLGAAVLRIPILY 179 Query: 182 GAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLAD 241 G + + AV F N D R HV D+A Sbjct: 180 GEVEK-----------------LEESAVTVMFDKVQFSNKSANMDHWQQRFPTHVKDVAT 222 Query: 242 GHVVAMEKLANKPGV-HIYNLGAGVGNSVLDVVNAFSKACGKPVN-YHFAPRREG----D 295 EK P + ++ + ++ A + A P + Sbjct: 223 VCRQLAEKRMLDPSIKGTFHWSGNEQMTKYEMACAIADAFNLPSSHLRPITDSPVLGAQR 282 Query: 296 LPAYWADASKADRELNWRVTRTLDEMAQDTWHW 328 D SK L +++ W Sbjct: 283 PRNAQLDCSKL-ETLGIGQRTPFRIGIKESL-W 313 >3RFT-A nrPDB Length = 267 Score = 84.4 bits (207), Expect = 6e-17, Method: Composition-based stats. Identities = 38/169 (22%), Positives = 64/169 (37%), Gaps = 18/169 (10%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 R+LVTG +G +G +L +++ L +L + G + V+ D+ + Sbjct: 5 RLLVTGAAGQLGRVMRERLAPMA-EILRLADLSPLDPA---------GPNEECVQCDLAD 54 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYY-DNNVNGTLRLISAMRAANVKNFI 120 + ++ D ++H G+ SV+KP E N+ G L A RA + Sbjct: 55 ANAVNAMVA--GCDGIVHLGGI-----SVEKPFEQILQGNIIGLYNLYEAARAHGQPRIV 107 Query: 121 FSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPD 169 F+SS G P+ + P YG SK E + Sbjct: 108 FASSNHTIGYYPQTERLGPDVPARPDGLYGVSKCFGENLARMYFDKFGQ 156 >3HFS-A nrPDB Length = 338 Score = 84.0 bits (206), Expect = 9e-17, Method: Composition-based stats. Identities = 54/341 (15%), Positives = 108/341 (31%), Gaps = 38/341 (11%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEAL 64 V GG+G++ S LLQ G+ V ++++ V ++E D+ +E Sbjct: 14 VVGGTGFVASLLVKLLLQKGYAVNTTVRDPDNQKKVSHLLELQELGDLKIFRADLTDELS 73 Query: 65 MTEILHDHAIDTVIHFAGLKAVGESVQKPLEYY-DNNVNGTLRLISAM-RAANVKNFIFS 122 + D V H A + P + G + ++ A RA +VK I + Sbjct: 74 FEAPIA--GCDFVFHVATPVHFAS--EDPENDMIKPAIQGVVNVMKACTRAKSVKRVILT 129 Query: 123 SSAT------------VYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDW 170 SSA V ++ P Y SK + E+ + + + Sbjct: 130 SSAAAVTINQLDGTGLVVDEKNWTDIEFLTSAKPPTWGYPASKTLAEKAAWKFAE-ENNI 188 Query: 171 SIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGV 230 + + G+ + D+ + + + G + + G+ Sbjct: 189 DLITVIPTLMAGSSLTSDVPSSIGLAMSLITGNEFLIN-GMKGMQMLSGSVSIA------ 241 Query: 231 RDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGK-PVNYHFA 289 HV D+ H+ EK + + SV ++ SK + V F Sbjct: 242 ----HVEDVCRAHIFVAEKESASGRY----ICCAANTSVPELAKFLSKRYPQYKVPTDFG 293 Query: 290 PRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQS 330 + K +E + ++E+ ++ + Sbjct: 294 DFPPK--SKLIISSEKLVKE-GFSFKYGIEEIYDESVEYFK 331 >4QUK-A nrPDB Length = 319 Score = 81.7 bits (200), Expect = 4e-16, Method: Composition-based stats. Identities = 62/329 (18%), Positives = 118/329 (35%), Gaps = 30/329 (9%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGK-HPTFVEGDIRN 61 V VTG SGYI S LL G+ V N + V +++ G K + ++ Sbjct: 3 VCVTGASGYIASWLVRLLLHRGYTVKATVRDPNDPKKVDHLVKLDGAKERLQLFKANLLE 62 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKP-LEYYDNNVNGTLRLISAM-RAANVKNF 119 E ++ V H A V+ P E D + GTL ++++ ++ ++K Sbjct: 63 EGAFDSVVQ--GCHGVFHTASPFYHD--VKDPQAELIDPALKGTLNVLNSCAKSPSLKRV 118 Query: 120 IFSSSAT--VYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRY 177 + +SS Y +P+ P V T + + +K + +++ + W Sbjct: 119 VLTSSIAAVAYNGKPRTPDVVVDETWFTDADF-CAKSNLWYVVSATLAEEAAWKFVKENN 177 Query: 178 FNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRD-SLAIFGNDYPTEDGTGVRDYIHV 236 + V +P+ +G Q + N I + G + A FG +++V Sbjct: 178 IDMVTINPAMVIGPLLQPVLNTSAAAILNLINGAQTFPNASFG-------------WVNV 224 Query: 237 MDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDL 296 D+A+ H++A E + + +VV + + + Sbjct: 225 KDVANAHILAYENASASGRHCL----VERVAHYSEVVRILRELYPSLQLPEKCADDKPYV 280 Query: 297 PAYWADASKADRE-LNWRV-TRTLDEMAQ 323 P Y KA L + ++ E + Sbjct: 281 PIYQVSKEKAKSLGLEYTPLEVSIKETVE 309 >4R1U-A nrPDB Length = 349 Score = 80.9 bits (198), Expect = 7e-16, Method: Composition-based stats. Identities = 64/337 (18%), Positives = 109/337 (32%), Gaps = 47/337 (13%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVII-LDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 V VTG G+I S LL+ G+ V + N + K L +E + T + D+ + Sbjct: 30 VCVTGAGGFIASWLVKLLLERGYTVRGTVRNPEDPKNGHLKELEGA-RERLTLHKVDLLD 88 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIF 121 + ++ H V H A P E + VNGT +I A A V+ +F Sbjct: 89 LQSIQSVV--HGCHGVFHTASPV-----TDNPDEMLEPAVNGTKNVIIASAEAKVRRVVF 141 Query: 122 SSSA-TVYGDQ--------PKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSI 172 +SS TVY D + + + ++ Y K + EQ D+ K + Sbjct: 142 TSSIGTVYMDPNTSRDVVVDESYWSDLEHCKNTKNWYCYGKTVAEQSAWDIAKENQVDLV 201 Query: 173 ALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRD 232 L P + + + N + Sbjct: 202 V--------------------VNPVVVLGPLLQPTINASTIHILKYLNGAAKTYVNATQS 241 Query: 233 YIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGK-PVNYHFAPR 291 Y+HV D+A H++ E + G +VV +K + P+ + Sbjct: 242 YVHVKDVALAHLLVYETNSASGRYICCETALHRG----EVVEILAKYFPEYPLPTKCSDE 297 Query: 292 REGDLPAYWADASKADRE-LNWRVTRTLDEMAQDTWH 327 + + Y K L + + + DT Sbjct: 298 KNPRVKPYKFSNQKLKDLGLEFTP---VKQCLYDTVR 331 >5U9C-A nrPDB Length = 292 Score = 79.8 bits (195), Expect = 2e-15, Method: Composition-based stats. Identities = 40/211 (18%), Positives = 73/211 (34%), Gaps = 36/211 (17%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 ++L+TGG+G +G++ L ++VI+ L F Sbjct: 7 KILITGGTGMLGAYVTSALKDTDYNVIV----------TERNTLNLSVPEAIFSY----- 51 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIF 121 + D ++HFA V ++P N T ++ A + ++ Sbjct: 52 -------ITAEKPDVILHFAAETDVDLCEREPARAGIYNHLATEQIAQAAKFCGA-WLLY 103 Query: 122 SSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNPV 181 SS+ V+G + K+ Y E P + YG+SKL+ E + + N + Sbjct: 104 LSSSNVFGGEGKLSYNE-LDIPLPMNYYGRSKLIGESSVRNAC------------TNNHL 150 Query: 182 GAHPSGDMGEDPQGIPNNLMPYIAQVAVGRR 212 +G P + I Q+ G Sbjct: 151 IIRAGWMIGGGPDKDHKFVGKIIQQIKAGST 181 >2GGS-A nrPDB Length = 273 Score = 78.6 bits (192), Expect = 3e-15, Method: Composition-based stats. Identities = 54/317 (17%), Positives = 95/317 (29%), Gaps = 65/317 (20%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 MR L+TG SG +G LL H+VI + N + + D+ Sbjct: 1 MRTLITGASGQLGIELSR-LLSERHEVIKVYNSSEIQGG---------------YKLDLT 44 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120 + + + + D +I+ A + V + + + Y N ++ A + + + Sbjct: 45 DFPRLEDFIIKKRPDVIINAAAMTDVDKCEIEKEKAYKINAEAVRHIVRAGKVID-SYIV 103 Query: 121 FSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNP 180 S+ V+ + E P P + YG SKL+ E I F Sbjct: 104 HISTDYVFDGEKGNYKEEDIP--NPINYYGLSKLLGETFALQ----DDSLIIRTSGIFRN 157 Query: 181 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA 240 G Y+ + + A G P A Sbjct: 158 KG-----------------FPIYVYKTLKEGKTVFAFKGYYSPIS--------------A 186 Query: 241 DGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFA-------PRRE 293 A+ +L I ++ AG S ++ + P +R Sbjct: 187 RKLASAILELLELRKTGIIHV-AGERISRFELALKIKEKFNLPGEVKEVDEVRGWIAKRP 245 Query: 294 GDLPAYWADASKADREL 310 D D+S+A + L Sbjct: 246 YD---SSLDSSRARKIL 259 >3PVZ-A nrPDB Length = 399 Score = 75.9 bits (185), Expect = 3e-14, Method: Composition-based stats. Identities = 52/237 (21%), Positives = 84/237 (35%), Gaps = 37/237 (15%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNG-HDVIILDNLCNSKRSVLPVIER----LGGKHPTFVE 56 R LV GG+G IG ++ + + ++D N+ ++ I + G TF Sbjct: 37 RFLVLGGAGSIGQAVTKEIFKRNPQKLHVVDISENNMVELVRDIRSSFGYINGDFQTFA- 95 Query: 57 GDIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKP---LEYYDNNVNGTLRLISAMRA 113 DI + I D D V++ + LK V S + P + D NV T + I Sbjct: 96 LDIGSIEYDAFIKADGQYDYVLNLSALKHV-RSEKDPFTLMRMIDVNVFNTDKTIQQSID 154 Query: 114 ANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIA 173 A K + S+ P + G SK ++E L + + +I+ Sbjct: 155 AGAKKYFCVSTDK---------------AANPVNMMGASKRIMEMFLM---RKSEEIAIS 196 Query: 174 LLRYFNPVGAHPSGDMG-------EDPQGIPNNLMPYIAQVAVGRRDSLA--IFGND 221 R+ N + S G P PN++ Y L IFG + Sbjct: 197 TARFANVAFSDGSLLHGFNQRIQKNQPIVAPNDIKRYFVTPQESGELCLMSCIFGEN 253 >1KC3-A nrPDB Length = 299 Score = 70.9 bits (172), Expect = 7e-13, Method: Composition-based stats. Identities = 66/345 (19%), Positives = 115/345 (33%), Gaps = 72/345 (20%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 M +L+ G +G +G L G+ +I LD H GD Sbjct: 1 MNILLFGKTGQVGWELQRSLAPVGN-LIALD------------------VHSKEFCGDFS 41 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120 N + E + D +++ A AV ++ +P N + A + Sbjct: 42 NPKGVAETVRKLRPDVIVNAAAHTAVDKAESEPELAQLLNATSVEAIAKAANETGA-WVV 100 Query: 121 FSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNP 180 S+ V+ IP+ E+ +P + YGK+KL E+ L D + + + Sbjct: 101 HYSTDYVFPGTGDIPWQET-DATSPLNVYGKTKLAGEKALQDNCPKHLIFRTSWV----- 154 Query: 181 VGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLA 240 G NN + ++A R+ +L++ + Y G LA Sbjct: 155 ------------YAGKGNNFAKTMLRLAKERQ-TLSVINDQYGAPTG--------AELLA 193 Query: 241 DGHVVAMEKLANKPGV-HIYNLGAGVGNSVLD-------------VVNAFSKACGKPVNY 286 D A+ NKP V +Y+L AG + D + A ++ P + Sbjct: 194 DCTAHAIRVALNKPEVAGLYHLVAGGTTTWHDYAALVFDEARKAGITLALTELNAVPTSA 253 Query: 287 HFAP-RREGDLPAYWADASKADRELN-----WRVTRTLDEMAQDT 325 + P R G+ + K R + W + M + Sbjct: 254 YPTPASRPGNSR---LNTEKFQRNFDLILPQW--ELGVKRMLTEM 293 >6G2J-P nrPDB Length = 377 Score = 58.2 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 30/119 (25%), Positives = 51/119 (42%), Gaps = 8/119 (6%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEAL 64 V G +G++G + L + G VII L ++ LG TF+E D R++ Sbjct: 58 VFGATGFLGRYVVNHLGRMGSQVIIPYRCDVYDIMHLRLMGDLG--QLTFLEWDARDKDS 115 Query: 65 MTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFSS 123 + + + + VI+ G E + ++ D VN + A + A V+ FI S Sbjct: 116 IRKAVQHSNV--VINLIG----REWETRNFDFEDVFVNIPRAIAQASKEAGVERFIHVS 168 >5YWN-A nrPDB Length = 334 Score = 58.2 bits (139), Expect = 5e-09, Method: Composition-based stats. Identities = 51/344 (14%), Positives = 111/344 (32%), Gaps = 40/344 (11%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 V V+G +GY+ +L G+ V+ S+ + + G V + + Sbjct: 5 VFVSGATGYLAQQIIALVLSKGYKVVG---SVRSEEKGANLKKLYGDDFSYEVVKVLEQK 61 Query: 63 ALMTEILHDHA-IDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAA--NVKNF 119 E L H + +H A + +NGT ++ +++ + Sbjct: 62 GAFDEALKKHPEVTIFLHTASPVTFEVEDTEKEILIPA-INGTKYVLQSIKDVAPQITRV 120 Query: 120 IFSSS-------------ATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKA 166 +++SS V + Y SK E+ + + Sbjct: 121 VYTSSVVAMSVPEELGSPDVVLSEASWSSLSYEQSKTHGVLAYFGSKQFAERAAWEFVEQ 180 Query: 167 Q-PDWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTE 225 + P+++++ + G + + ++ + ++ +D P Sbjct: 181 EKPNFALSTVNPVYIFGPQAKDEEVKGTLNHSAEMVNSVLKLNKD---------DDVPAT 231 Query: 226 DGTGVRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVN 285 GT +I V D+A H+ A EK K + + G ++LDVV K + + Sbjct: 232 TGT----FIDVRDVAKAHLAAFEKDEAKGERLLLSNTRFNGQTLLDVV---RKNFPQLAD 284 Query: 286 YHFAPRREGDLPAYWA--DASKADRELNWRVTRTLDEMAQDTWH 327 + D + + + K + L + + D+ Sbjct: 285 KLPVGKPHSDDFSAFKEWNDKKTKKILGFE-YFDFETSVVDSIK 327 >4QQR-A nrPDB Length = 301 Score = 56.7 bits (135), Expect = 1e-08, Method: Composition-based stats. Identities = 24/118 (20%), Positives = 43/118 (36%), Gaps = 10/118 (8%) Query: 57 GDIRNEALMTEILHDHAIDTVIHFAGL---KAVGESVQKPLEYYDNNVNGTLRLISAMRA 113 G +++ + + V + AG+ V +E NV GTL L R Sbjct: 44 GRLQDRQSIVADIESVKPSHVFNAAGVTGRPNVDWCESHKVETIRTNVAGTLTLADICRE 103 Query: 114 ANVKNFIFSSSATVY------GDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQK 165 + I ++ ++ I + E S Y K+K MVE++L + + Sbjct: 104 KGLV-LINYATGCIFEYDSGHPLGSGIGFKEEDTPNFTGSFYSKTKAMVEELLKNYEN 160 >2QYS-A nrPDB Length = 318 Score = 55.1 bits (131), Expect = 4e-08, Method: Composition-based stats. Identities = 27/120 (22%), Positives = 54/120 (45%), Gaps = 21/120 (17%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 ++L+ GG+GYIG+H L+ GH + +SK ++L + LG V+G++ Sbjct: 13 KILIFGGTGYIGNHMVKGSLKLGHPTYVFTRPNSSKTTLLDEFQSLGAI---IVKGELDE 69 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMR-AANVKNFI 120 + E++ +D VI + + + ++ A++ A N+K F+ Sbjct: 70 HEKLVELMK--KVDVVISALAFPQILDQFK---------------ILEAIKVAGNIKRFL 112 >3SLK-A nrPDB Length = 795 Score = 54.7 bits (130), Expect = 6e-08, Method: Composition-based stats. Identities = 32/139 (23%), Positives = 63/139 (45%), Gaps = 13/139 (9%) Query: 3 VLVTGGSGYIGSHTCVQL-LQNGH-DVIILDNLCNSKRSVLPVIERLG--GKHPTFVEGD 58 VLVTGG+G +G+ L ++ G +++++ + ++ +L G + D Sbjct: 533 VLVTGGTGALGAEVARHLVIERGVRNLVLVSRRGPAASGAAELVAQLTAYGAEVSLQACD 592 Query: 59 IRNEALMTEIL----HDHAIDTVIHFAGLKAVGESVQKPLEYYDNN----VNGTLRLISA 110 + + + ++L +H + V+H AG+ G S +E D V+G L+ Sbjct: 593 VADRETLAKVLASIPDEHPLTAVVHAAGVLDDGVSESLTVERLDQVLRPKVDGARNLLEL 652 Query: 111 MRAANVKNFIFSSSATVYG 129 + +V +FSS + V G Sbjct: 653 I-DPDVALVLFSSVSGVLG 670 >3U5T-A nrPDB Length = 267 Score = 53.6 bits (127), Expect = 1e-07, Method: Composition-based stats. Identities = 38/183 (20%), Positives = 64/183 (34%), Gaps = 25/183 (13%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVII-LDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 +VTG S IG+ +L +G V+I + V IE GGK T + D+ + Sbjct: 31 IVTGASRGIGAAIAARLASDGFTVVINYAGKAAAAEEVAGKIEAAGGKALT-AQADVSDP 89 Query: 63 ALMTEILHD-----HAIDTVIHFAG-LKAVGESVQKPLEY---YDNNVNGTLRLI-SAMR 112 A + + +D +++ AG + + + N+ GT + A + Sbjct: 90 AAVRRLFATAEEAFGGVDVLVNNAGIMPLTTIAETGDAVFDRVIAVNLKGTFNTLREAAQ 149 Query: 113 AANV-KNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWS 171 V I S++ V P Y +K VE + L K Sbjct: 150 RLRVGGRIINMSTSQVGLLHPSYGI------------YAAAKAGVEAMTHVLSKELRGRD 197 Query: 172 IAL 174 I + Sbjct: 198 ITV 200 >1QYC-A nrPDB Length = 308 Score = 53.2 bits (126), Expect = 2e-07, Method: Composition-based stats. Identities = 27/124 (21%), Positives = 48/124 (38%), Gaps = 19/124 (15%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHD--VIILDNLCNSKRSVLPVIERLGGKHPTFVEGDI 59 R+L+ G +GYIG H L GH +++ ++ +S ++E V G I Sbjct: 6 RILLIGATGYIGRHVAKASLDLGHPTFLLVRESTASSNSEKAQLLESFKASGANIVHGSI 65 Query: 60 RNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNF 119 + A + E + + +D VI VG + + +I A++ Sbjct: 66 DDHASLVEAVKN--VDVVI-----STVG----------SLQIESQVNIIKAIKEVGTVKR 108 Query: 120 IFSS 123 F S Sbjct: 109 FFPS 112 >5ITV-A nrPDB Length = 255 Score = 51.7 bits (122), Expect = 4e-07, Method: Composition-based stats. Identities = 38/190 (20%), Positives = 64/190 (33%), Gaps = 38/190 (20%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 VL+TGG+ IG L +V++ D + ++ + FV+ DI +E Sbjct: 10 VLITGGASGIGYAAVQAFLGQQANVVVADI---DEAQGEAMVRKENNDRLHFVQTDITDE 66 Query: 63 ALMTEILHDHAIDTVIHFAGLKAV-----GESVQKPLEYYD---------NNVNG----T 104 A HA+++ +H G V G + P+ + N+ G + Sbjct: 67 AAC-----QHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELSDWNKVLQVNLTGMFLMS 121 Query: 105 LRLISAMRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQ 164 + M AA N I + +V G Y SK V Q+ + Sbjct: 122 KHALKHMLAAGKGNIIN--TCSVGGLVAWPDIP----------AYNASKGGVLQLTKSMA 169 Query: 165 KAQPDWSIAL 174 I + Sbjct: 170 VDYAKHQIRV 179 >4AVY-A nrPDB Length = 242 Score = 51.7 bits (122), Expect = 5e-07, Method: Composition-based stats. Identities = 35/173 (20%), Positives = 63/173 (36%), Gaps = 15/173 (8%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 VLVTGGS IG+ +Q + G +V+ L + + E DI + Sbjct: 14 VLVTGGSSGIGAAIAMQFAELGAEVVALGLDADG-------VHAPRHPRIRREELDITDS 66 Query: 63 ALMTEILHDHA-IDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIF 121 + + +D +++ AG+ E L ++ + L L +AM A+ + + Sbjct: 67 QRLQRLFEALPRLDVLVNNAGISRDREEYD--LATFERVLR--LNLSAAMLASQLARPLL 122 Query: 122 SSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIAL 174 + G I + S + Y SK + Q+ L I + Sbjct: 123 AQRG---GSILNIASMYSTFGSADRPAYSASKGAIVQLTRSLACEYAAERIRV 172 >5GUP-L nrPDB Length = 377 Score = 50.9 bits (120), Expect = 7e-07, Method: Composition-based stats. Identities = 41/279 (14%), Positives = 91/279 (32%), Gaps = 49/279 (17%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEAL 64 V G +G++G + L + G VI+ L + LG F+E + +++ Sbjct: 58 VFGATGFLGRYVVNHLGRMGSQVIVPYRCEPYDTMHLRPMGDLG--QIIFMEWNGKDKDS 115 Query: 65 MTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFSSS 124 + +++ + VI+ G E K ++ D V + + A V+ I S Sbjct: 116 IRKVVEHSNV--VINLVG----REWETKNFDFEDVFVKIPHAIAQVSKEAGVEKLIHIS- 168 Query: 125 ATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNPVGAH 184 + P S Y +SK + E+ + +++ + G Sbjct: 169 --------HLNADIKSP-----SRYLRSKAVGEKEVRAAFP-----EATIIKPSDIFG-R 209 Query: 185 PSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHVMDLADGHV 244 + +P I+ + ++++D++ G + Sbjct: 210 EDRFLNYFASMRWFGGVPLISLGKETVKQP-------------------VYIVDVSKGII 250 Query: 245 VAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKP 283 A++ K + +G + D+V +P Sbjct: 251 NAIKDPDAKGKTFAF-VGPNR-YLLFDLVQYIFAVAYRP 287 >1UZM-A nrPDB Length = 247 Score = 50.9 bits (120), Expect = 7e-07, Method: Composition-based stats. Identities = 42/220 (19%), Positives = 74/220 (33%), Gaps = 47/220 (21%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 VLVTGG+ IG +L +GH V + + + + VE D+ + Sbjct: 18 VLVTGGNRGIGLAIAQRLAADGHKVAVTHRGSGAPKGLFG------------VEVDVTDS 65 Query: 63 ALMTEIL-----HDHAIDTVIHFAGLKA----VGESVQKPLEYYDNNVNGTLRLI----S 109 + H ++ ++ AGL A + + +K + + N+ G R+ Sbjct: 66 DAVDRAFTAVEEHQGPVEVLVSNAGLSADAFLMRMTEEKFEKVINANLTGAFRVAQRASR 125 Query: 110 AMRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPD 169 +M+ IF S V G + G + Y SK V + + + Sbjct: 126 SMQRNKFGRMIFIGS--VSGL---------WGIGNQAN-YAASKAGVIGMARSIARELSK 173 Query: 170 WSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAV 209 ++ N V G + L I Q A+ Sbjct: 174 ANV----TANVVAP------GYIDTDMTRALDERIQQGAL 203 >2NM0-A nrPDB Length = 253 Score = 50.5 bits (119), Expect = 9e-07, Method: Composition-based stats. Identities = 40/194 (20%), Positives = 58/194 (29%), Gaps = 41/194 (21%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 VLVTGG+ IG G V I + RS P L V+ DI + Sbjct: 24 VLVTGGNRGIGLAIARAFADAGDKVAI------TYRSGEPPEGFLA------VKCDITDT 71 Query: 63 ALMTEILHD----HAIDTVIHFAG-----LKAVGESVQKPLEYYDNNVNGTLRLI----S 109 + + + H V+ + S + + N+ GT R++ Sbjct: 72 EQVEQAYKEIEETHGPVEVLIANAGVTKDQLLMRMSEEDFTSVVETNLTGTFRVVKRANR 131 Query: 110 AMRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPD 169 AM A + SS V G Y SK + L + Sbjct: 132 AMLRAKKGRVVLISS--VVGLLGSAGQAN----------YAASKAGLVGFARSLARELGS 179 Query: 170 WSIALLRYFNPVGA 183 +I FN V Sbjct: 180 RNI----TFNVVAP 189 >1K2W-A nrPDB Length = 256 Score = 49.7 bits (117), Expect = 2e-06, Method: Composition-based stats. Identities = 49/277 (17%), Positives = 87/277 (31%), Gaps = 47/277 (16%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 L+TG + IG ++ G V I D + R+ I G + D+ ++A Sbjct: 9 LITGSARGIGRAFAEAYVREGARVAIADINLEAARATAAEI----GPAACAIALDVTDQA 64 Query: 64 LMTEILHD-----HAIDTVIHFAGL----KAVGESVQKPLEYYDNNVNGTLRLISAMRAA 114 + + + +ID +++ A L V + + + NV+GTL ++ A+ A Sbjct: 65 SIDRCVAELLDRWGSIDILVNNAALFDLAPIVEITRESYDRLFAINVSGTLFMMQAVARA 124 Query: 115 NV-----KNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPD 169 + I +S + G Y +K V + Sbjct: 125 MIAGGRGGKIINMAS--------QAGRRGEALVG----VYCATKAAVISLTQSA------ 166 Query: 170 WSIALLRYF-NPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGT 228 + L+R+ N P GE G+ Y + G + G Sbjct: 167 -GLNLIRHGINVNAIAPGVVDGEHWDGVDAKFADY-ENLPRGEKKRQV----GAAVPFGR 220 Query: 229 GVRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGV 265 R DL + A+ YN+ G Sbjct: 221 MGR----AEDLTGMAIFLATPEADYIVAQTYNVDGGN 253 >4B4O-A nrPDB Length = 298 Score = 49.0 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 58/296 (19%), Positives = 89/296 (30%), Gaps = 72/296 (24%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 MRVLV GG+G+IG+ L GH+V ++ R + G Sbjct: 1 MRVLVGGGTGFIGTALTQLLNARGHEVTLVSRKPGPGRITWDELAASGLP---------- 50 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPL----EYYDNNVNG-----TLRLISAM 111 + D ++ AG E++ PL E + V G T L A+ Sbjct: 51 ------------SCDAAVNLAG-----ENILNPLRRWNETFQKEVLGSRLETTQLLAKAI 93 Query: 112 RAA--NVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQ-- 167 A K ++ + Y Y E P G + A+ Sbjct: 94 TKAPQPPKAWVLVTGVAYYQPSLTAEYDEDSPGGDFD-------FFSNLVTKWEAAARLP 146 Query: 168 -PDWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTED 226 ++R +G G MG L+P+ G P Sbjct: 147 GDSTRQVVVRSGVVLG-RGGGAMGHM-------LLPFRL-------------GLGGPIGS 185 Query: 227 GTGVRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGK 282 G +IH+ DLA A+E + N A + + F A G+ Sbjct: 186 GHQFFPWIHIGDLAGILTHALE---ANHVHGVLNGVAPSSATNAEFAQTFGAALGR 238 >2GDZ-A nrPDB Length = 267 Score = 49.0 bits (115), Expect = 3e-06, Method: Composition-based stats. Identities = 23/118 (19%), Positives = 47/118 (39%), Gaps = 6/118 (5%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILD-NLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 LVTG + IG LL G V ++D NL + + E+ + F++ D+ ++ Sbjct: 11 LVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALHEQFEPQKTLFIQCDVADQ 70 Query: 63 ALMTEILHDH-----AIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAAN 115 + + +D +++ AG+ + + ++GT + M N Sbjct: 71 QQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQN 128 >1GEG-A nrPDB Length = 256 Score = 48.6 bits (114), Expect = 4e-06, Method: Composition-based stats. Identities = 43/215 (20%), Positives = 77/215 (35%), Gaps = 33/215 (15%) Query: 1 MR--VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGD 58 M+ LVTG IG ++L+++G V I D + ++V I + GG H V+ D Sbjct: 1 MKKVALVTGAGQGIGKAIALRLVKDGFAVAIADYNDATAKAVASEINQAGG-HAVAVKVD 59 Query: 59 IRNEALMTEILHD-----HAIDTVIHFA--GLKAVGESV--QKPLEYYDNNVNGTLRLIS 109 + + + + D +++ A ES+ + + Y+ NV G + I Sbjct: 60 VSDRDQVFAAVEQARKTLGGFDVIVNNAGVAPSTPIESITPEIVDKVYNINVKGVIWGIQ 119 Query: 110 AMRAANVK-----NFIFSSSATVYGDQPKIPYVESFPTGTPQ-SPYGKSKLMVEQILTDL 163 A A K I + S ++ G P+ + Y SK V + Sbjct: 120 AAVEAFKKEGHGGKIINACS-------------QAGHVGNPELAVYSSSKFAVRGLTQTA 166 Query: 164 QKAQPDWSIALLRYFNPVGAHPSGDMGEDPQGIPN 198 + I + Y G + E + + Sbjct: 167 ARDLAPLGITVNGYC--PGIVKTPMWAEIDRQVSE 199 >5OVL-A nrPDB Length = 300 Score = 48.2 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 25/135 (18%), Positives = 48/135 (35%), Gaps = 25/135 (18%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 VLVTGG+ IG +L +GH V + + + V+ D+ + Sbjct: 71 VLVTGGNRGIGLAIARRLAADGHKVAVTHRGSGAPDDLFG------------VQCDVTDS 118 Query: 63 ALMTEILHDH-----AIDTVIHFAGLK----AVGESVQKPLEYYDNNVNGTLRLI----S 109 A + + ++ ++ AG+ + + ++ E + N+ G R Sbjct: 119 AAVDRAFKEVEEHQGPVEVLVANAGISKDAFLMRMTEERFEEVINTNLTGAFRCAQRASR 178 Query: 110 AMRAANVKNFIFSSS 124 M+ IF S Sbjct: 179 TMQRKRFGRIIFIGS 193 >5OVJ-A nrPDB Length = 256 Score = 48.2 bits (113), Expect = 5e-06, Method: Composition-based stats. Identities = 25/135 (18%), Positives = 48/135 (35%), Gaps = 25/135 (18%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 VLVTGG+ IG +L +GH V + + + V+ D+ + Sbjct: 27 VLVTGGNRGIGLAIARRLAADGHKVAVTHRGSGAPDDLFG------------VQCDVTDS 74 Query: 63 ALMTEILHDH-----AIDTVIHFAGLK----AVGESVQKPLEYYDNNVNGTLRLI----S 109 A + + ++ ++ AG+ + + ++ E + N+ G R Sbjct: 75 AAVDRAFKEVEEHQGPVEVLVANAGISKDAFLMRMTEERFEEVINTNLTGAFRCAQRASR 134 Query: 110 AMRAANVKNFIFSSS 124 M+ IF S Sbjct: 135 TMQRKRFGRIIFIGS 149 >2PNF-A nrPDB Length = 248 Score = 48.2 bits (113), Expect = 6e-06, Method: Composition-based stats. Identities = 29/134 (21%), Positives = 48/134 (35%), Gaps = 13/134 (9%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 LVTG + IG +L G VII ++V I G VE ++ +E Sbjct: 11 LVTGSTRGIGRAIAEKLASAGSTVIITGTSGERAKAVAEEIANKYGVKAHGVEMNLLSEE 70 Query: 64 LMTEILHDH-----AIDTVIHFAGLK----AVGESVQKPLEYYDNNVNGTL----RLISA 110 + + + ID +++ AG+ + S+ E N+ GT + Sbjct: 71 SINKAFEEIYNLVDGIDILVNNAGITRDKLFLRMSLLDWEEVLKVNLTGTFLVTQNSLRK 130 Query: 111 MRAANVKNFIFSSS 124 M + SS Sbjct: 131 MIKQRWGRIVNISS 144 >4E6P-A nrPDB Length = 259 Score = 47.8 bits (112), Expect = 7e-06, Method: Composition-based stats. Identities = 22/113 (19%), Positives = 45/113 (39%), Gaps = 5/113 (4%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILD-NLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 L+TG + IG ++ G V I D ++ ++++ + D + Sbjct: 12 LITGSARGIGRAFAEAYVREGATVAIADIDIERARQAAAEIGPAAYAVQMDVTRQDSIDA 71 Query: 63 ALMTEILHDHAIDTVIHFAGL----KAVGESVQKPLEYYDNNVNGTLRLISAM 111 A+ + H +D +++ A L V + + + + NV GTL + A Sbjct: 72 AIAATVEHAGGLDILVNNAALFDLAPIVEITRESYEKLFAINVAGTLFTLQAA 124 >3WOH-A nrPDB Length = 251 Score = 47.4 bits (111), Expect = 8e-06, Method: Composition-based stats. Identities = 34/148 (22%), Positives = 61/148 (41%), Gaps = 16/148 (10%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDV-IILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 LVTGGS +G ++L ++G V I+ + +S + IERLGG + D+ + Sbjct: 15 LVTGGSRGLGRAMALRLARDGAAVAIVYVSDDSSAKETQGEIERLGGTARS-YRCDVSDA 73 Query: 63 ALMTEILHDH-----AIDTVIHFAGLK----AVGESVQKPLEYYDNNVNGTLRLISAMRA 113 +T + +D +++ AG+ A + + N+ G I A Sbjct: 74 EQVTRCVKAVTADLGPVDILVNNAGIIRDGLAASIKDEDYDAVMNTNLKGAFLFIKACYF 133 Query: 114 ANVKN----FIFSSS-ATVYGDQPKIPY 136 ++ I SS + V+G + Y Sbjct: 134 GFIRKRSGSIINISSVSGVFGSAGQANY 161 >3WYE-A nrPDB Length = 256 Score = 47.0 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 40/201 (19%), Positives = 71/201 (35%), Gaps = 23/201 (11%) Query: 1 MR--VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGD 58 M+ LVTG IG ++L+++G V I D + ++V I + GG H V+ D Sbjct: 1 MKKVALVTGAGQGIGKAIALRLVKDGFAVAIADYNDATAKAVASEINQAGG-HAVAVKVD 59 Query: 59 IRNEALMTEILHD-----HAIDTVIHFAGLKAVG----ESVQKPLEYYDNNVNGTLRLIS 109 + + + + D +++ AG+ + + + + Y NV I Sbjct: 60 VSDRDQVFAAVEQARKTLGGFDVIVNNAGIAQIKPLLEVTEEDLKQIYSVNVFSVFFGIQ 119 Query: 110 AMRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTP-QSPYGKSKLMVEQILTDLQKAQP 168 A A K +G + + G P S Y +K V + + Sbjct: 120 AAVEAFKK--------EGHGGKIINAASIAAIQGFPILSAYSTTKFAVRGLTQTAARDLA 171 Query: 169 DWSIALLRYFNPVGAHPSGDM 189 I + Y G +G Sbjct: 172 PLGITVNGYC--PGIVGTGMW 190 >1AE1-A nrPDB Length = 273 Score = 47.0 bits (110), Expect = 1e-05, Method: Composition-based stats. Identities = 39/178 (21%), Positives = 64/178 (35%), Gaps = 33/178 (18%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN-- 61 LVTGGS IG +L G V +++ + +E K VEG + + Sbjct: 25 LVTGGSKGIGYAIVEELAGLGARVYTC---SRNEKELDECLEIWREKGLN-VEGSVCDLL 80 Query: 62 -----EALMTEILH--DHAIDTVIHFAGLKAVGESVQKPLEYYD----NNVNGTLRLISA 110 + LM + H D ++ +++ AG+ E+ + Y+ N L Sbjct: 81 SRTERDKLMQTVAHVFDGKLNILVNNAGVVIHKEAKDFTEKDYNIIMGTNFEAAYHLSQI 140 Query: 111 M----RAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQ 164 +A+ N IF SS + P + S Y SK + Q+ L Sbjct: 141 AYPLLKASQNGNVIFLSSIAGFSALPSV------------SLYSASKGAINQMTKSLA 186 >3RWB-A nrPDB Length = 247 Score = 46.7 bits (109), Expect = 1e-05, Method: Composition-based stats. Identities = 32/145 (22%), Positives = 52/145 (35%), Gaps = 18/145 (12%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 LVTG + IG +L +G VI+ D GK + DI + Sbjct: 10 LVTGAAQGIGKAIAARLAADGATVIVSDI----NAEGAKAAAASIGKKARAIAADISDPG 65 Query: 64 LMTEILHDHA-----IDTVIHFAGLKAVGESVQKPLEY----YDNNVNGTLRLISA---- 110 + + + ID +++ A + L++ D N+ GT + A Sbjct: 66 SVKALFAEIQALTGGIDILVNNASIVPFVAWDDVDLDHWRKIIDVNLTGTFIVTRAGTDQ 125 Query: 111 MRAAN-VKNFIFSSSATVYGDQPKI 134 MRAA I +S T + P + Sbjct: 126 MRAAGKAGRVISIASNTFFAGTPNM 150 >4MOW-A nrPDB Length = 256 Score = 46.7 bits (109), Expect = 2e-05, Method: Composition-based stats. Identities = 41/206 (19%), Positives = 64/206 (31%), Gaps = 31/206 (15%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 +VTG S IG+ L G V++ + + G V GD+ A Sbjct: 18 IVTGASKGIGAAIAKALADEGAAVVVNYASSKAGADAVVSAITEAGGRAVAVGGDVSKAA 77 Query: 64 LMTEILHDHAIDT-----------VIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMR 112 I+ V FA ++A+ E + +D NV G L A Sbjct: 78 DAQRIVDTAIETYGRLDVLVNNSGVYEFAPIEAITE--EHYRRQFDTNVFGVLLTTQAAV 135 Query: 113 AA--NVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQI--LTDLQKAQP 168 + I SS P + Y +K V+ I + L+ Sbjct: 136 KHLGEGASIINISSVVTSITPPA------------SAVYSGTKGAVDAITGVLALELGPR 183 Query: 169 DWSIALLRYFNPV--GAHPSGDMGED 192 + + V G H +G +G D Sbjct: 184 KIRVNAINPGMIVTEGTHSAGIIGSD 209 >3RKU-A nrPDB Length = 287 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 32/188 (17%), Positives = 63/188 (33%), Gaps = 24/188 (12%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHD----VIILDNLCNSKRSVLPVIERLGGKHPTFVEGD 58 VL+TG S IG T ++ L+ + ++ L + + + + D Sbjct: 36 VLITGASAGIGKATALEYLEASNGDMKLILAARRLEKLEELKKTIDQEFPNAKVHVAQLD 95 Query: 59 IRNEALMTEILHD-----HAIDTVIHFAGLKAVGE-----SVQKPLEYYDNNVNGTLRLI 108 I + + + ID +++ AG + + + + +D NV + + Sbjct: 96 ITQAEKIKPFIENLPQEFKDIDILVNNAGKALGSDRVGQIATEDIQDVFDTNVTALINIT 155 Query: 109 SAMR-AANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQ 167 A+ KN GD + + S Y SK V L+K Sbjct: 156 QAVLPIFQAKN---------SGDIVNLGSIAGRDAYPTGSIYCASKFAVGAFTDSLRKEL 206 Query: 168 PDWSIALL 175 + I ++ Sbjct: 207 INTKIRVI 214 >3WTC-A nrPDB Length = 262 Score = 46.3 bits (108), Expect = 2e-05, Method: Composition-based stats. Identities = 40/187 (21%), Positives = 65/187 (34%), Gaps = 27/187 (14%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEAL 64 VTG + IG ++L ++G DVI+LD ++ +E LG + DI N Sbjct: 13 VTGAAQGIGKAIALRLAKDGADVILLDVKQDTLAETAKEVEALGRRAVALT-ADISNRDQ 71 Query: 65 MTEILHD-----HAIDTVIHFAGLKAV----GESVQKPLEYYDNNVNGTLRLISAM---- 111 L D +D +++ AG+ V + + + NV G L + A Sbjct: 72 FRSTLADAAKTLGGLDIMVNNAGICQVKPILDIEPAEIEKIFSINVQGVLWGMQAAATLF 131 Query: 112 RAANVK-NFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDW 170 + K I + S E +P Y +K V + K Sbjct: 132 KEKGTKGKIINACSIA---------GHEGYPLLG---AYSATKFAVRALTQSAAKELASS 179 Query: 171 SIALLRY 177 I + Y Sbjct: 180 GITVNSY 186 >5ILO-A nrPDB Length = 271 Score = 45.5 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 37/209 (17%), Positives = 70/209 (33%), Gaps = 32/209 (15%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEAL 64 VTGG+G IG QLL G + + +L ++ + + + ++ D+ N+ Sbjct: 20 VTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDNLEEFVKLRAAHPTQSVMIIKMDVANKKG 79 Query: 65 MTEILHDHA-----IDTVIHFAGLKAVGESVQKPLEYYDNNVNG----TLRLISAMRAAN 115 + + A ID V++ AG+ + N+ G TL + M N Sbjct: 80 VEATYEEIAKTFGNIDIVVNVAGIFN----DKDVQRTLLVNLGGIINSTLSALPYMGKDN 135 Query: 116 VKN---FIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSI 172 + SS V G P YG +K + L + + Sbjct: 136 GGKGGIVVNMSS--VVGLDPMFIIP----------VYGATKAGIINFTRCLAN-EKYYQR 182 Query: 173 ALLRYFNPVGAHPSGDMGEDPQGIPNNLM 201 + +++ P M + ++ Sbjct: 183 SGIKFVTVC---PGATMTDMFTNFTEKII 208 >1BDB-A nrPDB Length = 277 Score = 45.5 bits (106), Expect = 4e-05, Method: Composition-based stats. Identities = 34/146 (23%), Positives = 58/146 (39%), Gaps = 22/146 (15%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 VL+TGG+ +G + + G V +LD L +E G + + GD+R+ Sbjct: 8 VLITGGASGLGRALVDRFVAEGAKVAVLDKSA----ERLAELETDHGDNVLGIVGDVRSL 63 Query: 63 ALMTE-----ILHDHAIDTVIHFAGLKAVGESVQK---------PLEYYDNNVNGTLRLI 108 + + IDT+I AG+ ++ E + NV G + + Sbjct: 64 EDQKQAASRCVARFGKIDTLIPNAGIWDYSTALVDLPEESLDAAFDEVFHINVKGYIHAV 123 Query: 109 SAM---RAANVKNFIFS-SSATVYGD 130 A A+ N IF+ S+A Y + Sbjct: 124 KACLPALVASRGNVIFTISNAGFYPN 149 >3A28-C nrPDB Length = 258 Score = 44.7 bits (104), Expect = 5e-05, Method: Composition-based stats. Identities = 22/121 (18%), Positives = 47/121 (38%), Gaps = 10/121 (8%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPV-IERLGGKHPTFVEGDIRNE 62 +VTGG+ IG +L +G D+ + D +++ + + + FV D+ ++ Sbjct: 6 MVTGGAQGIGRGISEKLAADGFDIAVADLPQQEEQAAETIKLIEAADQKAVFVGLDVTDK 65 Query: 63 ALMTEILHD-----HAIDTVIHFAGLKAVG----ESVQKPLEYYDNNVNGTLRLISAMRA 113 A + + D +++ AG+ + + + + Y NV I A Sbjct: 66 ANFDSAIDEAAEKLGGFDVLVNNAGIAQIKPLLEVTEEDLKQIYSVNVFSVFFGIQAASR 125 Query: 114 A 114 Sbjct: 126 K 126 >1QYD-A nrPDB Length = 313 Score = 44.7 bits (104), Expect = 5e-05, Method: Composition-based stats. Identities = 26/123 (21%), Positives = 48/123 (39%), Gaps = 19/123 (15%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHP---TFVEGD 58 RVL+ GG+GYIG + GH +L S + ++ L +E Sbjct: 6 RVLIVGGTGYIGKRIVNASISLGHPTYVL--FRPEVVSNIDKVQMLLYFKQLGAKLIEAS 63 Query: 59 IRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAA-NVK 117 + + + + L +D VI +++ L+L+ A++ A N+K Sbjct: 64 LDDHQRLVDALK--QVDVVISALAGG-----------VLSHHILEQLKLVEAIKEAGNIK 110 Query: 118 NFI 120 F+ Sbjct: 111 RFL 113 >2HRB-A nrPDB Length = 274 Score = 44.7 bits (104), Expect = 6e-05, Method: Composition-based stats. Identities = 35/196 (17%), Positives = 59/196 (30%), Gaps = 50/196 (25%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 LVTG + IG +L + ++L ++ + G P F + DI + Sbjct: 6 LVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQ 65 Query: 64 LMTEIL-----HDHAIDTVIHFAGLKAVGESVQKPLEY-------YDNNVNGTLR----L 107 + + ++ +++ A V P+ + N T L Sbjct: 66 SIRALRDFLRKEYGGLNVLVNNAA---VAFKSDDPMPFDIKAEMTLKTNFFATRNMCNEL 122 Query: 108 ISAMRAANVKNFIFSSSATV---------------------YGDQPKI--PYVESFPT-- 142 + M+ + SS GD + +VE Sbjct: 123 LPIMKPHG--RVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEV 180 Query: 143 ----GTPQSPYGKSKL 154 G P SPYG SKL Sbjct: 181 HEREGWPNSPYGVSKL 196 >3OSU-A nrPDB Length = 246 Score = 44.3 bits (103), Expect = 8e-05, Method: Composition-based stats. Identities = 29/136 (21%), Positives = 55/136 (40%), Gaps = 17/136 (12%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPT--FVEGDIRN 61 LVTG S IG +QL + G++V + N SK V+E + K ++ ++ + Sbjct: 8 LVTGASRGIGRSIALQLAEEGYNVAV--NYAGSKEKAEAVVEEIKAKGVDSFAIQANVAD 65 Query: 62 EALMTEILHDH-----AIDTVIHFAGLK----AVGESVQKPLEYYDNNVNGTLRLIS--- 109 + ++ + ++D +++ AG+ + Q+ + D N+ G I Sbjct: 66 ADEVKAMIKEVVSQFGSLDVLVNNAGITRDNLLMRMKEQEWDDVIDTNLKGVFNCIQKAT 125 Query: 110 -AMRAANVKNFIFSSS 124 M I SS Sbjct: 126 PQMLRQRSGAIINLSS 141 >1HE4-A nrPDB Length = 206 Score = 44.0 bits (102), Expect = 9e-05, Method: Composition-based stats. Identities = 30/136 (22%), Positives = 52/136 (38%), Gaps = 16/136 (11%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 ++ + G +G G T Q +Q G++V +L + S P V GD+ Sbjct: 5 KIAIFGATGQTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPR-------PAHVVVGDVLQ 57 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIF 121 A + + + D VI G + P G +++AM+A V + Sbjct: 58 AADVDKTVA--GQDAVIVLLG----TRNDLSPTTVMS---EGARNIVAAMKAHGVDKVVA 108 Query: 122 SSSATVYGDQPKIPYV 137 +SA + D K+P Sbjct: 109 CTSAFLLWDPTKVPPR 124 >3KZV-A nrPDB Length = 254 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 36/189 (19%), Positives = 60/189 (31%), Gaps = 33/189 (17%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 +LVTG S IG L D ++ + S + L ++ G +V GDI + Sbjct: 5 ILVTGVSRGIGKSIVDVLFSLDKDTVVY-GVARS-EAPLKKLKEKYGDRFFYVVGDITED 62 Query: 63 ALMTEILHD-----HAIDTVIHFAGLKAVGESVQKPLE--------YYDNNVNGTLRLIS 109 +++ ++++ ID+ V E VQ E YD N + L+ Sbjct: 63 SVLKQLVNAAVKGHGKIDS---LVANAGVLEPVQNVNEIDVNAWKKLYDINFFSIVSLVG 119 Query: 110 AM---RAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKA 166 N +F SS + YG SK + L Sbjct: 120 IALPELKKTNGNVVFVSSDAC------------NMYFSSWGAYGSSKAALNHFAMTLANE 167 Query: 167 QPDWSIALL 175 + + Sbjct: 168 ERQVKAIAV 176 >4KMS-A nrPDB Length = 249 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 36/229 (15%), Positives = 83/229 (36%), Gaps = 37/229 (16%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 +VTGG+ IG T ++L G V+ N ++ + + E+ G K + ++ + Sbjct: 14 IVTGGTRGIGKATALELKNKGLTVVA--NFFSNYDAAKEMEEKYGIKTKCW---NVADFE 68 Query: 64 LMTEILHDH------AIDTVIHFAGLK----AVGESVQKPLEYYDNNVNGTLR----LIS 109 + + + + +++ AG+ S Q + + N+N ++ Sbjct: 69 ECRQAVKEIEEEFKKPVSILVNNAGITKDKMLHRMSHQDWNDVINVNLNSCFNMSSSVME 128 Query: 110 AMRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPD 169 MR + + SS + V Y +K + L + Sbjct: 129 QMRNQDYGRIVNISSINA-----QAGQVGQTN-------YSAAKAGIIGFTKALARETAS 176 Query: 170 WSIALLRYFNPV--GAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLA 216 +I + N + G + +G P+ + ++ I + +G+ + +A Sbjct: 177 KNITV----NCIAPGYIATEMVGAVPEDVLAKIINSIPKKRLGQPEEIA 221 >2V6G-A nrPDB Length = 364 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 45/289 (15%), Positives = 84/289 (29%), Gaps = 33/289 (11%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 L+ G +G IG+ +L + R P +V+ DI + Sbjct: 5 LIVGVTGIIGNSLAE-ILPLADTPGGPWKVYGVARRTRPAWHE--DNPINYVQCDISDPD 61 Query: 64 LMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAA--NVKNF-- 119 + V H + S ++ E + N ++ A+ N+K+ Sbjct: 62 --DSQAKLSPLTDVTHVFYVTWANRSTEQ--ENCEANSKMFRNVLDAVIPNCPNLKHISL 117 Query: 120 -----IFSSSATVYGDQP--KIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSI 172 + YG PY E P + Y +E I+ + + + + Sbjct: 118 QTGRKHYMGPFESYGKIESHDPPYTEDLPRLKYMNFY----YDLEDIMLEEVEKKEGLTW 173 Query: 173 ALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRD 232 ++ R N G P M NL+ + A + + G D Sbjct: 174 SVHRPGNIFGFSPYSMM---------NLVGTLCVYAAICKHEGKVLRFTGCKAAWDGYSD 224 Query: 233 YIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACG 281 +A+ H+ A K +N+ G ++ G Sbjct: 225 CSDADLIAEHHIWAAVDPYAKN--EAFNVSNGDVFKWKHFWKVLAEQFG 271 >1GEE-A nrPDB Length = 261 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 40/203 (19%), Positives = 76/203 (37%), Gaps = 22/203 (10%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVII-LDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 V++TG S +G ++ V++ + + SVL I+++GG+ V+GD+ Sbjct: 10 VVITGSSTGLGKSMAIRFATEKAKVVVNYRSKEDEANSVLEEIKKVGGEAIA-VKGDVTV 68 Query: 62 EALMTEILHD-----HAIDTVIHFAGL----KAVGESVQKPLEYYDNNVNGTLRLISAMR 112 E+ + ++ +D +I+ AGL + S+ + D N+ G Sbjct: 69 ESDVINLVQSAIKEFGKLDVMINNAGLENPVSSHEMSLSDWNKVIDTNLTGAFLGSREAI 128 Query: 113 AANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSI 172 V+N I + + KIP+ Y SK ++ + L + Sbjct: 129 KYFVENDIKGTVINMSSVHEKIPWPLFVH-------YAASKGGMKLMTETLALEY---AP 178 Query: 173 ALLRYFNPV-GAHPSGDMGEDPQ 194 +R N GA + E Sbjct: 179 KGIRVNNIGPGAINTPINAEKFA 201 >1YXM-A nrPDB Length = 303 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 33/176 (18%), Positives = 72/176 (40%), Gaps = 17/176 (9%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVII----LDNLCNSKRSVLPVIERLGGKHPTFVEGDI 59 +VTGG+ IG +LL+ G +V+I L+ L ++ + + ++ +I Sbjct: 22 IVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIPIQCNI 81 Query: 60 RNEALMTEILHD-----HAIDTVIHFAG----LKAVGESVQKPLEYYDNNVNGTLRLISA 110 RNE + ++ I+ +++ G A S + + N+ GT + A Sbjct: 82 RNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGTFYMCKA 141 Query: 111 MRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQS-PYGKSK-LMVEQILTDLQ 164 + ++ +K S K + + +G ++ Y +K L +E + ++ Sbjct: 142 VYSSWMKE--HGGSIVNIIVPTKAGFPLAVHSGAARAGVYNLTKSLALEWACSGIR 195 >1H5Q-A nrPDB Length = 265 Score = 43.6 bits (101), Expect = 1e-04, Method: Composition-based stats. Identities = 35/183 (19%), Positives = 63/183 (34%), Gaps = 12/183 (6%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 ++VTGG+ IG + G +V ++ V + + G + D+ N Sbjct: 17 IIVTGGNRGIGLAFTRAVAAAGANVAVIYRSAADAVEVTEKVGKEFGVKTKAYQCDVSNT 76 Query: 63 ALMTEILHDHAIDT-----VIHFAGLKAVGESV----QKPLEYYDNNVNGTLRLISAMRA 113 ++T+ + D +I AG+ V + + YD NV G A+ Sbjct: 77 DIVTKTIQQIDADLGPISGLIANAGVSVVKPATELTHEDFAFVYDVNVFGVFNTCRAVAK 136 Query: 114 ANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIA 173 ++ S +I S Q Y SK ++ L +W+ A Sbjct: 137 LWLQKQQKGSIVVTSSMSSQIINQSSLNGSLTQVFYNSSKAACSNLVKGLA---AEWASA 193 Query: 174 LLR 176 +R Sbjct: 194 GIR 196 >3PXX-A nrPDB Length = 287 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 39/184 (21%), Positives = 69/184 (37%), Gaps = 21/184 (11%) Query: 3 VLVTGGS-GYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFV------ 55 VLVTGG+ G SH L + G D+I+ D + + + P+ + Sbjct: 13 VLVTGGARGQGRSHAVK-LAEEGADIILFDICHDIETNEYPLATSRDLEEAGLEVEKTGR 71 Query: 56 -----EGDIRNEALMTEILHD-----HAIDTVIHFAGLKAVGES--VQKPLEYYDNNVNG 103 E D+R+ A ++ L + +D V+ AG+ +G VQ + +D + G Sbjct: 72 KAYTAEVDVRDRAAVSRELANAVAEFGKLDVVVANAGICPLGAHLPVQAFADAFDVDFVG 131 Query: 104 TLRLISAMRAANVKNFIFSSSATVYGDQ-PKIPYVESFPTGTPQSPYGKSKLMVEQILTD 162 + + A ++ +V G P P G + Y +K +V+ Sbjct: 132 VINTVHAALPYLTSGASIITTGSVAGLIAAAQPPGAGGPQGPGGAGYSYAKQLVDSYTLQ 191 Query: 163 LQKA 166 L Sbjct: 192 LAAQ 195 >6CGE-A nrPDB Length = 328 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 36/178 (20%), Positives = 63/178 (35%), Gaps = 28/178 (15%) Query: 3 VLVTGGSGYIGSHTCVQLL---QNGHDVIILDNLCNSKRSVLPVIERLGGKHPTF--VEG 57 VL+TG S IG H V+L V ++ + L + ++ Sbjct: 6 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQL 65 Query: 58 DIRNEALM---TEILHDHAIDTVIHFAGLKAVG----ESVQKPLEYYDNNVNGTLRLISA 110 D+R+ + E + + +D ++ AGL +G D NV GT+R++ A Sbjct: 66 DVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQA 125 Query: 111 ----MRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQ 164 M+ + + S G +P+ Y SK +E + L Sbjct: 126 FLPDMKRRGSGRVLVTGSV---GGLMGLPF---------NDVYCASKFALEGLCESLA 171 >1A27-A nrPDB Length = 289 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 36/178 (20%), Positives = 63/178 (35%), Gaps = 28/178 (15%) Query: 3 VLVTGGSGYIGSHTCVQLL---QNGHDVIILDNLCNSKRSVLPVIERLGGKHPTF--VEG 57 VL+TG S IG H V+L V ++ + L + ++ Sbjct: 5 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQL 64 Query: 58 DIRNEALM---TEILHDHAIDTVIHFAGLKAVG----ESVQKPLEYYDNNVNGTLRLISA 110 D+R+ + E + + +D ++ AGL +G D NV GT+R++ A Sbjct: 65 DVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQA 124 Query: 111 ----MRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQ 164 M+ + + S G +P+ Y SK +E + L Sbjct: 125 FLPDMKRRGSGRVLVTGSV---GGLMGLPF---------NDVYCASKFALEGLCESLA 170 >2CFC-A nrPDB Length = 250 Score = 43.2 bits (100), Expect = 2e-04, Method: Composition-based stats. Identities = 34/186 (18%), Positives = 56/186 (30%), Gaps = 28/186 (15%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 +VTG S G + L G V LD + V D+ +E Sbjct: 6 IVTGASSGNGLAIATRFLARGDRVAALDLSAETLEETARTHWHAYADKVLRVRADVADEG 65 Query: 64 LMTEILHD-----HAIDTVIHFAGLKAVGES-------VQKPLEYYDNNVNGTL----RL 107 + + AID +++ AG+ E+ V++ + NV G + Sbjct: 66 DVNAAIAATMEQFGAIDVLVNNAGITGNSEAGVLHTTPVEQFDKVMAVNVRGIFLGCRAV 125 Query: 108 ISAMRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQ 167 + M + +S V S +S Y SK V Q+ + Sbjct: 126 LPHMLLQGAGVIVNIAS------------VASLVAFPGRSAYTTSKGAVLQLTKSVAVDY 173 Query: 168 PDWSIA 173 I Sbjct: 174 AGSGIR 179 >3OML-A nrPDB Length = 613 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 29/152 (19%), Positives = 57/152 (37%), Gaps = 19/152 (12%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILD---------NLCNSKRSVLPVIERLGGKHPTFV 55 VTG +G + + G V++ D + V+ I + GG+ Sbjct: 24 VTGAGAGLGREYALLFAERGAKVVVNDLGGTHSGDGASQRAADIVVDEIRKAGGEAVADY 83 Query: 56 EGDIRNEALMTEILHDHA-IDTVIHFAGL----KAVGESVQKPLEYYDNNVNGTLRLISA 110 I ++ + +D +++ AG+ V S Q D ++ G+ + A Sbjct: 84 NSVIDGAKVIETAIKAFGRVDILVNNAGILRDRSLVKTSEQDWNLVNDVHLKGSFKCTQA 143 Query: 111 ----MRAANVKNFIFSSS-ATVYGDQPKIPYV 137 M+ N I +SS + +YG+ ++ Y Sbjct: 144 AFPYMKKQNYGRIIMTSSNSGIYGNFGQVNYT 175 >4K6F-A nrPDB Length = 255 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 25/173 (14%), Positives = 50/173 (28%), Gaps = 25/173 (14%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEAL 64 VTGG G +G ++L GH V++ + N+ G+ D+ + Sbjct: 16 VTGGMGGLGEAVSIRLNDAGHRVVVTYSPNNTGADRWLTEMHAAGREFHAYPVDVADHDS 75 Query: 65 MTEILHDH-----AIDTVIHFAG----LKAVGESVQKPLEYYDNNVNGTLRLI----SAM 111 + + +D +++ AG + N++ + M Sbjct: 76 CQQCIEKIVRDVGPVDILVNNAGITRDMTLRKLDKVNWDAVIRTNLDSVFNMTKPVCDGM 135 Query: 112 RAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQ 164 + SS V G + + Y +K + L Sbjct: 136 VERGWGRIVNISS--VNGSKGSVGQTN----------YAAAKAGMHGFTKSLA 176 >3EMK-A nrPDB Length = 246 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 24/137 (17%), Positives = 44/137 (32%), Gaps = 19/137 (13%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 + LVTG +G +G L G V L ++ L + G+ ++ + Sbjct: 9 KALVTGATGGLGEAIARALHAQGAIV----GLHGTREEKLKELAAELGERIFVFPANLSD 64 Query: 62 EALMTEILHD-----HAIDTVIHFAGLK----AVGESVQKPLEYYDNNVNGTLRLIS--- 109 + + +D +++ AG+ V S + N+ L Sbjct: 65 REAVKALGQKAEEEMGGVDILVNNAGITRDGLFVRMSDEDWDAVLTVNLTSVFNLTRELT 124 Query: 110 --AMRAANVKNFIFSSS 124 MR N I +S Sbjct: 125 HPMMRRRN-GRIINITS 140 >3VZS-A nrPDB Length = 257 Score = 42.8 bits (99), Expect = 2e-04, Method: Composition-based stats. Identities = 25/135 (18%), Positives = 45/135 (33%), Gaps = 17/135 (12%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFV--EGDIRNE 62 VTGG G IG+ C +L ++G V+ + +E+ F+ EG++ + Sbjct: 19 VTGGMGGIGTAICQRLAKDGFRVVA--GCGPNSPRREKWLEQQKALGFDFIASEGNVADW 76 Query: 63 ALMTEILHDHA-----IDTVIHFAGL----KAVGESVQKPLEYYDNNVNGTLR----LIS 109 +D +I+ AG+ + D N+ +I Sbjct: 77 DSTKTAFDKVKSEVGEVDVLINNAGITRDVVFRKMTRADWDAVIDTNLTSLFNVTKQVID 136 Query: 110 AMRAANVKNFIFSSS 124 M + SS Sbjct: 137 GMADRGWGRIVNISS 151 >2O23-A nrPDB Length = 265 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 22/122 (18%), Positives = 46/122 (37%), Gaps = 19/122 (15%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEAL 64 +TGG+ +G T +L+ G ++LD + + + G + F D+ +E Sbjct: 17 ITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKL----GNNCVFAPADVTSEKD 72 Query: 65 MTEILHDHA-----IDTVIHFAGLKAVGESV----------QKPLEYYDNNVNGTLRLIS 109 + L +D ++ AG+ ++ + D N+ GT +I Sbjct: 73 VQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIR 132 Query: 110 AM 111 + Sbjct: 133 LV 134 >1N5D-A nrPDB Length = 288 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 24/139 (17%), Positives = 47/139 (33%), Gaps = 21/139 (15%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN-- 61 LVTG + IG L + ++L ++ + G P F + DI + Sbjct: 8 LVTGANKGIGFAIVRDLCRQFAGDVVLTARDVARGQAAVKQLQAEGLSPRFHQLDIIDLQ 67 Query: 62 --EALMTEILHDH-AIDTVIHFAGLKAVGESVQKPLEY-------YDNNVNGTLR----L 107 AL + ++ +D +++ A + + P + N GT L Sbjct: 68 SIRALCDFLRKEYGGLDVLVNNAAIAF---QLDNPTPFHIQAELTMKTNFMGTRNVCTEL 124 Query: 108 ISAMRAANVKNFIFSSSAT 126 + ++ + SS Sbjct: 125 LPLIKPQG--RVVNVSSTE 141 >3EZL-A nrPDB Length = 256 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 26/135 (19%), Positives = 46/135 (34%), Gaps = 17/135 (12%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFV--EGDIRNE 62 VTGG G IG+ C +L ++G V+ + + +E F EG++ + Sbjct: 18 VTGGMGGIGTSICQRLHKDGFRVVA--GCGPNSPRRVKWLEDQKALGFDFYASEGNVGDW 75 Query: 63 ALMTEILHDHA-----IDTVIHFAGL----KAVGESVQKPLEYYDNNVNGTLR----LIS 109 + ID +++ AG+ + + D N+ +I Sbjct: 76 DSTKQAFDKVKAEVGEIDVLVNNAGITRDVVFRKMTREDWQAVIDTNLTSLFNVTKQVID 135 Query: 110 AMRAANVKNFIFSSS 124 M I SS Sbjct: 136 GMVERGWGRIINISS 150 >4DBZ-A nrPDB Length = 281 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 33/166 (19%), Positives = 59/166 (35%), Gaps = 30/166 (18%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR--- 60 LVTG + IG +L + G V + R+ L + G + D+R Sbjct: 30 LVTGATSGIGLEIARRLGKEGLRVFVCARGEEGLRTTLKELREAGVEADGRT-CDVRSVP 88 Query: 61 -NEALMTEILHDHAI-DTVIHFAGLKAVGESVQKP----LEYYDNNVNG----TLRLISA 110 EAL+ ++ + D +++ AG G + + L+ + N+ G T +++ A Sbjct: 89 EIEALVAAVVERYGPVDVLVNNAGRPGGGATAELADELWLDVVETNLTGVFRVTKQVLKA 148 Query: 111 --MRAANVKNFIF-SSSATVYGDQPKIPYVESFPTGTPQSPYGKSK 153 M + +S+ G PY SK Sbjct: 149 GGMLERGTGRIVNIASTGGKQGLVHAA-------------PYSASK 181 >3RSH-A nrPDB Length = 251 Score = 42.4 bits (98), Expect = 3e-04, Method: Composition-based stats. Identities = 25/134 (18%), Positives = 45/134 (33%), Gaps = 17/134 (12%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 LVTG S IG L + G VI + S I G + + ++ N Sbjct: 16 LVTGASRGIGKAIAELLAERGAKVIG----TATSESGAQAISDYLGDNGKGMALNVTNPE 71 Query: 64 LMTEILHDH-----AIDTVIHFAGLK----AVGESVQKPLEYYDNNVNGTLRL----ISA 110 + +L +D +++ AG+ + ++ + + N+ RL + Sbjct: 72 SIEAVLKAITDEFGGVDILVNNAGITRDNLLMRMKEEEWSDIMETNLTSIFRLSKAVLRG 131 Query: 111 MRAANVKNFIFSSS 124 M I S Sbjct: 132 MMKKRQGRIINVGS 145 >3F9I-A nrPDB Length = 249 Score = 42.0 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 26/130 (20%), Positives = 47/130 (36%), Gaps = 13/130 (10%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 L+TG S IGS L + G VII S L + + T ++ N+ Sbjct: 18 LITGASSGIGSAIARLLHKLGSKVII----SGSNEEKLKSLGNALKDNYTIEVCNLANKE 73 Query: 64 LMTEILHDHA-IDTVIHFAGLKAVGESVQKPLEYYD--------NNVNGTLRLISAMRAA 114 + ++ + +D ++ AG+ + +++ + +D N I M Sbjct: 74 ECSNLISKTSNLDILVCNAGITSDTLAIRMKDQDFDKVIDINLKANFILNREAIKKMIQK 133 Query: 115 NVKNFIFSSS 124 I SS Sbjct: 134 RYGRIINISS 143 >1AHH-A nrPDB Length = 255 Score = 42.0 bits (97), Expect = 4e-04, Method: Composition-based stats. Identities = 22/112 (19%), Positives = 43/112 (38%), Gaps = 9/112 (8%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 ++TG IG + G V++ D ++ V+ I++LGG+ DI +E Sbjct: 15 IITGAGAGIGKEIAITFATAGASVVVSDINADAANHVVDEIQQLGGQAFA-CRCDITSEQ 73 Query: 64 LMTEIL-----HDHAIDTVIHFAGLKAV---GESVQKPLEYYDNNVNGTLRL 107 ++ + +D +++ AG + Y+ NV L Sbjct: 74 ELSALADFAISKLGKVDILVNNAGGGGPKPFDMPMADFRRAYELNVFSFFHL 125 >6CI9-A nrPDB Length = 259 Score = 41.6 bits (96), Expect = 4e-04, Method: Composition-based stats. Identities = 34/168 (20%), Positives = 56/168 (33%), Gaps = 31/168 (18%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTF--VEGDIRN 61 +VTGGS IG G DV+I ++ + + L G V D+ + Sbjct: 13 IVTGGSKGIGRGIAETFANAGVDVVI---TGRNQDDLDRTVADLSGTRGKVTAVRADVTD 69 Query: 62 EALMTEILHD-----HAIDTVIHFAGL----KAVGESVQKPLEYYDNNVNGTLRL----I 108 + + +D V AG+ + + + N GT+ + + Sbjct: 70 PEDARRTVAETVSRHGGLDIVCANAGIFPSGRLEDLTPDDIEQVLGVNFKGTVYIVQAAL 129 Query: 109 SAMRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSP-YGKSKLM 155 A+ A+ + +SS T P G P YG SK Sbjct: 130 QALTASGHGRVVVTSSIT-------GPIT-----GYPGWSHYGASKAA 165 >2GAS-A nrPDB Length = 307 Score = 41.6 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 25/123 (20%), Positives = 50/123 (40%), Gaps = 21/123 (17%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNG---HDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGD 58 ++L+ G +G IG H ++ G + ++ + + +I+ +EGD Sbjct: 4 KILILGPTGAIGRHIVWASIKAGNPTYALVRKTITAANPETKEELIDNYQSLGVILLEGD 63 Query: 59 IRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAA-NVK 117 I + + + + +D VI AG + + V+ +I A++ A NVK Sbjct: 64 INDHETLVKAIK--QVDIVICAAGRLLIEDQVK---------------IIKAIKEAGNVK 106 Query: 118 NFI 120 F Sbjct: 107 KFF 109 >3U9L-A nrPDB Length = 324 Score = 41.6 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 66/287 (22%), Positives = 98/287 (34%), Gaps = 32/287 (11%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVII--LDNLCNSKRSVLPVIERLGGKHPTF--VEGD 58 +L+TG S G T L GH V D + + +V + +E D Sbjct: 8 ILITGASSGFGRLTAEALAGAGHRVYASMRDIVGRNASNVEAIAGFARDNDVDLRTLELD 67 Query: 59 IR-----NEALMTEILHDHAIDTVIHFAG----LKAVGESVQKPLEYYDNNVNGTLRLIS 109 ++ + A+ I D ID +IH AG A + ++ E YD NV T R+ Sbjct: 68 VQSQVSVDRAIDQIIGEDGRIDVLIHNAGHMVFGPAEAFTPEQFAELYDINVLSTQRVNR 127 Query: 110 AMRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQ-SPYGKSKLMVEQILTDLQKAQP 168 A + G I S P +PY +K ++ I + Sbjct: 128 AALPHMRRQKH--------GLLIWISSSSSAGGTPPYLAPYFAAKAAMDAIAVQYARELS 179 Query: 169 DWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGT 228 W I GA SG G+P++ A+ A A G + Sbjct: 180 RWGIETSII--VPGAFTSGTNHFAHSGVPDD----HARQAEYEAGPNAGLGEEIKKAFAA 233 Query: 229 GVRDYIHVMDLADGHVVAMEKLANKPGVHIY----NLGAGVGNSVLD 271 V V +AD V + + K ++ GA VG SVLD Sbjct: 234 IVPPDADVSLVADAIVRVVGTASGKRPFRVHVDPAEDGADVGFSVLD 280 >1OOE-A nrPDB Length = 236 Score = 41.6 bits (96), Expect = 5e-04, Method: Composition-based stats. Identities = 33/171 (19%), Positives = 60/171 (35%), Gaps = 11/171 (6%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 +V+V GG G +GS +NG+ V+ +D N + L + + E + Sbjct: 5 KVIVYGGKGALGSAILEFFKKNGYTVLNIDLSANDQADS----NILVDGNKNWTEQEQSI 60 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIF 121 L +D V AG A G S + ++ + S+ AA + Sbjct: 61 LEQTASSLQGSQVDGVFCVAGGWA-GGSASSKDFVKNADLMIKQSVWSSAIAAKL----- 114 Query: 122 SSSATVYGDQPKIPYVESFPTGTPQSP-YGKSKLMVEQILTDLQKAQPDWS 171 +++ G ++ + TP YG +K V + + L Sbjct: 115 ATTHLKPGGLLQLTGAAAAMGPTPSMIGYGMAKAAVHHLTSSLAAKDSGLP 165 >3ZV3-A nrPDB Length = 281 Score = 41.3 bits (95), Expect = 6e-04, Method: Composition-based stats. Identities = 30/145 (20%), Positives = 55/145 (37%), Gaps = 22/145 (15%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 L+TGG+ +G + + G V +LD L +E G + V GD+R+ Sbjct: 9 LITGGASGLGRALVDRFVAEGARVAVLDKSA----ERLRELEVAHGGNAVGVVGDVRSLQ 64 Query: 64 LMTEILHD-----HAIDTVIHFAGLKAVGESVQK---------PLEYYDNNVNGTLRLIS 109 IDT+I AG+ ++ + + NV G + + Sbjct: 65 DQKRAAERCLAAFGKIDTLIPNAGIWDYSTALADLPEDKIDAAFDDIFHVNVKGYIHAVK 124 Query: 110 AM---RAANVKNFIFS-SSATVYGD 130 A ++ + +F+ S+A Y + Sbjct: 125 ACLPALVSSRGSVVFTISNAGFYPN 149 >3AUT-A nrPDB Length = 269 Score = 41.3 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 42/197 (21%), Positives = 74/197 (37%), Gaps = 34/197 (17%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLG--GKHPTFVEGDIR 60 V++TGGS +G V+ Q V+I N N++ L + + G V+GD+ Sbjct: 18 VVITGGSTGLGRAMAVRFGQEEAKVVI--NYYNNEEEALDAKKEVEEAGGQAIIVQGDVT 75 Query: 61 NEALMTEI----LHDHA-IDTVIHFAG----LKAVGESVQKPLEYYDNN----VNGTLRL 107 E + + + + +D +I+ AG + + S+ + D N G+ Sbjct: 76 KEEDVVNLVQTAIKEFGTLDVMINNAGVENPVPSHELSLDNWNKVIDTNLTGAFLGSREA 135 Query: 108 ISAMRAANVK-NFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKA 166 I ++K N I SS V+ P +V Y SK ++ + L Sbjct: 136 IKYFVENDIKGNVINMSS--VHEMIPWPLFVH----------YAASKGGMKLMTETLALE 183 Query: 167 QPDWSIALLRYFNPVGA 183 I + N +G Sbjct: 184 YAPKGIRV----NNIGP 196 >2AE2-A nrPDB Length = 260 Score = 41.3 bits (95), Expect = 7e-04, Method: Composition-based stats. Identities = 42/225 (18%), Positives = 82/225 (36%), Gaps = 37/225 (16%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN-- 61 LVTGGS IG +L G V +++ + + + K VE + + Sbjct: 13 LVTGGSRGIGYGIVEELASLGASVYTC---SRNQKELNDCLTQWRSKGFK-VEASVCDLS 68 Query: 62 -----EALMTEILHDH--AIDTVIHFAGLKAVGE----SVQKPLEYYDNNVNGTLRLISA 110 + LM + + ++ +++ AG+ E +V+ N L Sbjct: 69 SRSERQELMNTVANHFHGKLNILVNNAGIVIYKEAKDYTVEDYSLIMSINFEAAYHLSVL 128 Query: 111 M----RAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILT--DLQ 164 +A+ N +F SS V G +PY ++ YG +K ++Q+ + Sbjct: 129 AHPFLKASERGNVVFISS--VSGAL-AVPY---------EAVYGATKGAMDQLTRCLAFE 176 Query: 165 KAQPDWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAV 209 A+ + + + + +DP+ NL I + A+ Sbjct: 177 WAKDNIRVNGVGPG-VIATSLVEMTIQDPEQ-KENLNKLIDRCAL 219 >5PGZ-A nrPDB Length = 276 Score = 40.9 bits (94), Expect = 8e-04, Method: Composition-based stats. Identities = 28/180 (15%), Positives = 67/180 (37%), Gaps = 14/180 (7%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 +V+VTG S IG L + G V++ + V+ LG ++ G + + Sbjct: 20 KVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMED 79 Query: 62 EALMTE-ILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFI 120 + I+ + + L + ++ L + ++++ R++ N +++ Sbjct: 80 MTFAEQFIVKAGKLMGGLDMLILNHITQTS---LSLFHDDIHSVRRVMEV----NFLSYV 132 Query: 121 FSSSATV------YGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIAL 174 S+A + G I + T +PY SK ++ + ++ + + Sbjct: 133 VMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNV 192 >3D3W-A nrPDB Length = 244 Score = 40.9 bits (94), Expect = 8e-04, Method: Composition-based stats. Identities = 26/170 (15%), Positives = 51/170 (30%), Gaps = 27/170 (15%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 RVLVTG IG T L G V+ + S++ V D+ + Sbjct: 9 RVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVR-----ECPGIEPVCVDLGD 63 Query: 62 EALMTEILHDHAI-DTVIHFAG----LKAVGESVQKPLEYYDNNVNGTLRLISAMRAANV 116 L D +++ A + + + ++ N+ +++ + + Sbjct: 64 WEATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNLRAVIQVSQIVARGLI 123 Query: 117 KN-----FIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILT 161 + SS S T S Y +K ++ + Sbjct: 124 ARGVPGAIVNVSSQC------------SQRAVTNHSVYCSTKGALDMLTK 161 >5VT6-A nrPDB Length = 269 Score = 40.9 bits (94), Expect = 9e-04, Method: Composition-based stats. Identities = 22/134 (16%), Positives = 43/134 (32%), Gaps = 13/134 (9%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 VTGG G +G+ +L G V + + N S + ER G+ D+ + Sbjct: 29 FVTGGMGGLGAAISRRLHDAGMAVAVSHSERNDHVSTWLMHERDAGRDFKAYAVDVADFE 88 Query: 64 LMTEILHDH-----AIDTVIHFAGL----KAVGESVQKPLEYYDNNVNGTLRL----ISA 110 +D +I+ AG+ + + +++ + I+ Sbjct: 89 SCERCAEKVLADFGKVDVLINNAGITRDATFMKMTKGDWDAVMRTDLDAMFNVTKQFIAG 148 Query: 111 MRAANVKNFIFSSS 124 M + S Sbjct: 149 MVERRFGRIVNIGS 162 >5LCX-A nrPDB Length = 316 Score = 40.9 bits (94), Expect = 9e-04, Method: Composition-based stats. Identities = 27/119 (22%), Positives = 48/119 (40%), Gaps = 15/119 (12%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVII-LDNLCNSKRSVLPVIERLGG--KHPTFVEGDIR 60 LVTG + IG C QL + G VI+ N + +++ L F + D+ Sbjct: 11 LVTGANKGIGFEICRQLAEKGIIVILTSRNEKRGLEARQKLLKELNVSENRLVFHQLDVT 70 Query: 61 NEALMTEIL-----HDHAIDTVIHFAGLKAV----GESVQKPLEYYDNNVNGTLRLISA 110 + A + + +D +++ AG+ V SV EY + + L+ + A Sbjct: 71 DLASVAAVAVFIKSKFGKLDILVNNAGVSGVEMVGDVSVFN--EYIEADFK-ALQALEA 126 >3DWF-A nrPDB Length = 276 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 28/174 (16%), Positives = 59/174 (33%), Gaps = 20/174 (11%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 +V+VTG S IG L + G V++ + + V+ LG ++ G + + Sbjct: 13 KVIVTGASKGIGREIAYHLAKMGAHVVVTARSKEALQKVVARCLELGAASAHYIAGSMED 72 Query: 62 EALMTEILHDHA----------IDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAM 111 E + + ++ V++ GE + + + N + + L A Sbjct: 73 MTFAEEFVAEAGNLMGGLDMLILNHVLYNRLTFFHGE-IDNVRKSMEVNFHSFVVLSVAA 131 Query: 112 RAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQK 165 + S + ++P P Y SK ++ + L+ Sbjct: 132 MP------MLMQSQGSIAVVSSVAGKITYPLIAP---YSASKFALDGFFSTLRS 176 >3UN1-A nrPDB Length = 260 Score = 40.5 bits (93), Expect = 0.001, Method: Composition-based stats. Identities = 35/227 (15%), Positives = 65/227 (28%), Gaps = 50/227 (22%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 V++TG S IG+ + V+ + I+ V GDI Sbjct: 31 VVITGASQGIGAGLVRAYRDRNYRVV----------ATSRSIKPSADPDIHTVAGDISKP 80 Query: 63 ALMTEILHD-----HAIDTVIHFA----GLKAVGESVQKPLEYYDNNVNGTLRLISA--- 110 I+ + ID++++ A V + + NV G + Sbjct: 81 ETADRIVREGIERFGRIDSLVNNAGVFLAKPFVEMTQEDYDHNLGVNVAGFFHITQRAAA 140 Query: 111 -MRAANVKNFIFSSSATVYGDQPKIPYVESFPT-GTPQSPYGKSKLMVEQILTDLQK--A 166 M + + +++ V P G P + +K + + L + Sbjct: 141 EMLKQGSGHIVSITTSLV-----------DQPMVGMPSALASLTKGGLNAVTRSLAMEFS 189 Query: 167 QPDWSIALLRYF-------------NPVGAHPSGDMGEDPQGIPNNL 200 + + + G HP G MGE + L Sbjct: 190 RSGVRVNAVSPGVIKTPMHPAETHSTLAGLHPVGRMGEIRDVVDAVL 236 >3GRP-A nrPDB Length = 266 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 34/173 (19%), Positives = 58/173 (33%), Gaps = 23/173 (13%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 + LVTG +G IG G V L ++ L I GK ++ + Sbjct: 29 KALVTGATGGIGEAIARCFHAQGAIV----GLHGTREDKLKEIAADLGKDVFVFSANLSD 84 Query: 62 EALMTEI-----LHDHAIDTVIHFAGLK----AVGESVQKPLEYYDNNVNG----TLRLI 108 + ++ ID +++ AG+ V Q + N+ T LI Sbjct: 85 RKSIKQLAEVAEREMEGIDILVNNAGITRDGLFVRMQDQDWDDVLAVNLTAASTLTRELI 144 Query: 109 SAMRAANVKNFIFSSSA-TVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQIL 160 +M I +S V G+ + Y + G SK + ++I Sbjct: 145 HSMMRRRYGRIINITSIVGVVGNPGQTNYCAAKAGLI-----GFSKALAQEIA 192 >3V8B-A nrPDB Length = 283 Score = 40.1 bits (92), Expect = 0.001, Method: Composition-based stats. Identities = 31/137 (22%), Positives = 49/137 (35%), Gaps = 15/137 (10%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 L+TG IG T + L +G V L V I GG+ E D+ +E Sbjct: 32 LITGAGSGIGRATALALAADGVTVGALGRTRTEVEEVADEIVGAGGQAIAL-EADVSDEL 90 Query: 64 LMTEILHDHA-----IDTVIHFAGLKAVGESVQK--PLEYYDN---NVNGTLRLIS---- 109 M + D +D V+ AG+ V + P E+ + N+ GT + Sbjct: 91 QMRNAVRDLVLKFGHLDIVVANAGINGVWAPIDDLKPFEWDETIAVNLRGTFLTLHLTVP 150 Query: 110 AMRAANVKNFIFSSSAT 126 ++ + SS Sbjct: 151 YLKQRGGGAIVVVSSIN 167 >1CYD-A nrPDB Length = 244 Score = 40.1 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 23/167 (13%), Positives = 53/167 (31%), Gaps = 17/167 (10%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 +R LVTG IG T L +G V+ + + ++ + + G P V D+ Sbjct: 8 LRALVTGAGKGIGRDTVKALHASGAKVVAV---TRTNSDLVSLAKECPGIEP--VCVDLG 62 Query: 61 NEALMTEILHDHAI-DTVIHFAG----LKAVGESVQKPLEYYDNNVNGTLRLISAMRAAN 115 + + L D +++ A + + + + N+ ++ + Sbjct: 63 DWDATEKALGGIGPVDLLVNNAALVIMQPFLEVTKEAFDRSFSVNLRSVFQVSQMVARDM 122 Query: 116 VKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTD 162 + + S V + + Y +K + + Sbjct: 123 INRGVPGSIVNVSSMVAHVTFPNLIT-------YSSTKGAMTMLTKA 162 >4CQL-A nrPDB Length = 261 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 42/244 (17%), Positives = 75/244 (30%), Gaps = 27/244 (11%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGK------HPTFVEG 57 LVTG IG V+L G V D + + + ++ G K + + Sbjct: 15 LVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAFQA 74 Query: 58 DIRNEALMTEILHDHA-----IDTVIHFAGLKAVGE-----SVQKPLEYYDNNVNGTLRL 107 D+ +L +V+ E S + N+ GT + Sbjct: 75 DVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLV 134 Query: 108 ISAMRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQ 167 A A V N S + K+ V Y SK ++ Q A Sbjct: 135 TQAAAQALVSNGCRGSIINISSIVGKVGNVGQTN-------YAASKAG---VIGLTQTAA 184 Query: 168 PDWSIALLRYFNPV-GAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTED 226 + +R + + G + + PQ + + + I +G + +A +ED Sbjct: 185 RELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFLASED 244 Query: 227 GTGV 230 + Sbjct: 245 SGYI 248 >4NBT-A nrPDB Length = 240 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 37/242 (15%), Positives = 77/242 (31%), Gaps = 41/242 (16%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILD--NLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 +TGG+ +G + + G VI D +L S +V + ++ + Sbjct: 11 ITGGAKGLGQAIALAYAEEGAKVIAGDLGDLTYSHPNVEGMY------------LNVTDV 58 Query: 63 ALMTEILHDH-----AIDTVIHFAGLK--AVGESVQKP--LEYYDNNVNGTLRLIS---- 109 + + ID +++ AG+ A+ + + D N+ G L Sbjct: 59 TGVEKFYQSVIDKYGKIDILVNNAGITKDAMTRKMTEAQWDAVIDVNLKGVFNLTRLVGP 118 Query: 110 AMRAANVKNFIFSSS-ATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQP 168 M+ + I SS V+G+ + Y +K V + K Sbjct: 119 QMQTNGYGSIINISSVVGVFGNIGQAN-------------YAATKAGVIGLTMTWAKEFA 165 Query: 169 DWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGT 228 + G + + PQ + + +G+ + +A ++D + Sbjct: 166 LKGANVRVNAIAPGYIMTDILKTVPQDLLDKFAALTMLNRLGQPEEIAKVALFLASDDAS 225 Query: 229 GV 230 V Sbjct: 226 YV 227 >5IZ4-A nrPDB Length = 271 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 36/175 (20%), Positives = 62/175 (35%), Gaps = 18/175 (10%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVII--LDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 +TG + IG+ T ++ Q G V I D+ S + + R G + D+ + Sbjct: 19 ITGSASGIGAATALRFAQAGWSVAIGNFDDSTRDAASTVEALCRDAGAQTLIFDADVGKD 78 Query: 63 ALMTEILHDHA-----IDTVIHFAGLKAVG--ESVQKPLEY-----YDNNVNGTLRLISA 110 A + A ID +I+ AG V + + ++ Y N+ G ++ A Sbjct: 79 ADCRHAVDMVASRWQRIDALINCAGTTRVIPHNAFDQIDDFEFERVYRVNLIGLYQMTRA 138 Query: 111 MRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQK 165 V S+SAT + + Y SK V + L + Sbjct: 139 A----VPLLRESASATRSTSVVNVSSLAGLNGTGSSIAYAASKGAVNTLTLSLAR 189 >4FC7-A nrPDB Length = 277 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 34/217 (15%), Positives = 69/217 (31%), Gaps = 25/217 (11%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE- 62 +TGG IG +++G +I + + G+ + D+R Sbjct: 31 FITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSMDVRAPP 90 Query: 63 ---ALMTEILHDHA-IDTVIHFAG----LKAVGESVQKPLEYYDNNVNGTLRLISAMRAA 114 A + + L + ID +I+ A A S D + +GT + + Sbjct: 91 AVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNVSRVLYEK 150 Query: 115 ---NVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQP--D 169 + I + +AT+ G++ + V + G +K V+ + L + Sbjct: 151 FFRDHGGVIVNITATL-GNRGQALQVHA----------GSAKAAVDAMTRHLAVEWGPQN 199 Query: 170 WSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQ 206 + L G +G + + Q Sbjct: 200 IRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQ 236 >5JS6-A nrPDB Length = 274 Score = 39.7 bits (91), Expect = 0.002, Method: Composition-based stats. Identities = 33/197 (16%), Positives = 64/197 (32%), Gaps = 36/197 (18%) Query: 17 CVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEALMTEILHD----- 71 + +G V+I D + R++ + F+ D+ E + ++ + Sbjct: 28 VRAFVNSGARVVICDKDESGGRALEQEL-----PGAVFILCDVTQEDDVKTLVSETIRRF 82 Query: 72 HAIDTVIHFAGLKAVGE-----SVQKPLEYYDNNVNGTLRLISAMRAANVK---NFIFSS 123 +D V++ AG + S Q + + N+ GT L K N I S Sbjct: 83 GRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLALPYLRKSQGNVINIS 142 Query: 124 SATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQ--KAQPDWSIALLRYFNPV 181 S + G + V PY +K V + L ++ + + N Sbjct: 143 S--LVGAIGQAQAV----------PYVATKGAVTAMTKALALDESPYGVRVNCISPGNIW 190 Query: 182 GAHPSGDMGEDPQGIPN 198 + E +P+ Sbjct: 191 ----TPLWEELAALMPD 203 >2HSD-A nrPDB Length = 253 Score = 39.3 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 28/137 (20%), Positives = 57/137 (41%), Gaps = 17/137 (12%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 V++TGG+ +G+ Q + G V++ D L + + G + D+ E Sbjct: 8 VIITGGARGLGAEAARQAVAAGARVVLADVLDEEGAATAREL----GDAARYQHLDVTIE 63 Query: 63 ALMTEIL-----HDHAIDTVIHFAGLKA----VGESVQKPLEYYDNNVNGTL----RLIS 109 ++ ++D +++ AG+ ESV++ + + N+ G +I Sbjct: 64 EDWQRVVAYAREEFGSVDGLVNNAGISTGMFLETESVERFRKVVEINLTGVFIGMKTVIP 123 Query: 110 AMRAANVKNFIFSSSAT 126 AM+ A + + SSA Sbjct: 124 AMKDAGGGSIVNISSAA 140 >4IIV-A nrPDB Length = 267 Score = 39.3 bits (90), Expect = 0.002, Method: Composition-based stats. Identities = 27/149 (18%), Positives = 48/149 (32%), Gaps = 15/149 (10%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 VLVTG S IG QL +G ++ + + + G + + D+ N Sbjct: 29 VLVTGASKGIGRAIARQLAADGFNIGVHYHRDAAGAQETLNAIVANGGNGRLLSFDVANR 88 Query: 63 ALMTEILHDHAIDT-----VIHFAGL----KAVGESVQKPLEYYDNNVNGTLRLISAM-- 111 E+L V+ AG+ S N++ +I Sbjct: 89 EQCREVLEHEIAQHGAWYGVVSNAGIARDAAFPALSNDDWDAVIHTNLDSFYNVIQPCIM 148 Query: 112 ----RAANVKNFIFSSSATVYGDQPKIPY 136 + SS + V G++ ++ Y Sbjct: 149 PMIGARQGGRIITLSSVSGVMGNRGQVNY 177 >4IIN-A nrPDB Length = 271 Score = 38.9 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 34/193 (17%), Positives = 58/193 (30%), Gaps = 28/193 (14%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 VL+TG S IG+ L G V I L G ++ D + Sbjct: 31 NVLITGASKGIGAEIAKTLASMGLKVWINYRSNAEVADALKNELEEKGYKAAVIKFDAAS 90 Query: 62 EALMTEILH-----DHAIDTVIHFAGLK----AVGESVQKPLEYYDNN----VNGTLRLI 108 E+ E + D + +++ AG+ A+ + DNN G + Sbjct: 91 ESDFIEAIQTIVQSDGGLSYLVNNAGVVRDKLAIKMKTEDFHHVIDNNLTSAFIGCREAL 150 Query: 109 SAMRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQP 168 M + + + +S E G Y SK I A Sbjct: 151 KVMSKSRFGSVVNVASI----------IGERGNMGQTN--YSASK--GGMIAMSKSFAYE 196 Query: 169 DWSIALLRYFNPV 181 ++ +R+ + Sbjct: 197 G-ALRNIRFNSVT 208 >3BHI-A nrPDB Length = 276 Score = 38.9 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 36/198 (18%), Positives = 64/198 (32%), Gaps = 54/198 (27%) Query: 4 LVTGGSGYIGSHTCVQL--LQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 LVTGG+ IG L L +G V+ ++ + +V + G P F + DI + Sbjct: 8 LVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAE--GLSPRFHQLDIDD 65 Query: 62 EALMTEIL-----HDHAIDTVIHFAGLKAVGESVQKPLEY-------YDNNVNGTL---- 105 + + +D +++ AG+ V P + N GT Sbjct: 66 LQSIRALRDFLRKEYGGLDVLVNNAGIAF---KVADPTPFHIQAEVTMKTNFFGTRDVCT 122 Query: 106 RLISAMRAANVKNFIFSSSA-------TVYGDQPKI----------------PYVESFPT 142 L+ ++ + SS + + + +VE Sbjct: 123 ELLPLIKPQG--RVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKK 180 Query: 143 ------GTPQSPYGKSKL 154 G P S YG +K+ Sbjct: 181 GVHQKEGWPSSAYGVTKI 198 >1HXH-A nrPDB Length = 253 Score = 38.9 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 34/172 (19%), Positives = 64/172 (37%), Gaps = 30/172 (17%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 LVTGG+ +G LL G V D + + + + G+ FV D+ +EA Sbjct: 10 LVTGGASGVGLEVVKLLLGEGAKVAFSDINEAAGQQLAAEL----GERSMFVRHDVSSEA 65 Query: 64 LMTEILHDHA-----IDTVIHFAGLKAVGESVQKPLEYY--------DNNVNGTLRLISA 110 T ++ ++ +++ AG+ G+ LE + ++ G + I+A Sbjct: 66 DWTLVMAAVQRRLGTLNVLVNNAGILLPGDMETGRLEDFSRLLKINTESVFIGCQQGIAA 125 Query: 111 MRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTD 162 M+ + I +S +P + + Y SK V + Sbjct: 126 MKETG-GSIINMAS-----VSSWLPIEQ-------YAGYSASKAAVSALTRA 164 >3V2G-A nrPDB Length = 271 Score = 38.9 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 32/164 (19%), Positives = 56/164 (34%), Gaps = 24/164 (14%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILD-NLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 VTGGS IG+ +L G V + N ++V+ IE+ GG+ + D R+ Sbjct: 35 FVTGGSRGIGAAIAKRLALEGAAVALTYVNAAERAQAVVSEIEQAGGRAVA-IRADNRDA 93 Query: 63 ALMTEILHD-----HAIDTVIHFAGLKAVG----ESVQKPLEYYDNNVNGTLRLISAMRA 113 + + + + +D +++ AG+ +V E N I + Sbjct: 94 EAIEQAIRETVEALGGLDILVNSAGIWHSAPLEETTVADFDEVMAVNFRAPFVAIRSASR 153 Query: 114 A--NVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLM 155 + I S +P+ S Y SK Sbjct: 154 HLGDGGRIITIGSN----LAELVPWPG-------ISLYSASKAA 186 >1Q7C-A nrPDB Length = 244 Score = 38.9 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 26/134 (19%), Positives = 48/134 (35%), Gaps = 17/134 (12%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 LVTG S IG L G VI S+ + + LG + ++ + A Sbjct: 9 LVTGASRGIGRAIAETLAARGAKVIG---TATSENGAQAISDYLGANGKGLM-LNVTDPA 64 Query: 64 LMTEILHDH-----AIDTVIHFAGLK----AVGESVQKPLEYYDNNVNGTLRL----ISA 110 + +L +D +++ AG+ + ++ + + N++ RL + A Sbjct: 65 SIESVLEKIRAEFGEVDILVNNAGITRDNLLMRMKDEEWNDIIETNLSSVFRLSKAVMRA 124 Query: 111 MRAANVKNFIFSSS 124 M I S Sbjct: 125 MMKKRHGRIITIGS 138 >5WQO-A nrPDB Length = 234 Score = 38.9 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 38/185 (20%), Positives = 60/185 (32%), Gaps = 21/185 (11%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 VL+ G S IG LQ G V + + + ER G+ V GD+ Sbjct: 8 NVLIVGASRGIGLGLADAFLQRGAQVFAVARRPQGSPGLQALAERA-GERLQAVTGDLNQ 66 Query: 62 EALMTEILH---DHAIDTVIHFAGLKAVGESV------QKPLEYYDNNVNGTLRLISAM- 111 I + ID +I AG+ + ++ + + N LRL A+ Sbjct: 67 HDCAERIGEMLGERRIDRLIVNAGIYGPQQQDVAEIDAEQTAQLFLTNAIAPLRLARALS 126 Query: 112 -RAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDW 170 R + F SS P YG SK + ++ + + Sbjct: 127 GRVSRGGVVAFMSS-------QMASLALGLSATMPL--YGASKAALNSLVRSWEGEFEEL 177 Query: 171 SIALL 175 +LL Sbjct: 178 PFSLL 182 >6NRP-A nrPDB Length = 263 Score = 38.9 bits (89), Expect = 0.003, Method: Composition-based stats. Identities = 25/117 (21%), Positives = 47/117 (40%), Gaps = 9/117 (7%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 R+LVTG S IG +QL + G DV + ++ + + G++ ++ D+ Sbjct: 26 RILVTGSSRGIGKAIALQLAKAGFDVTVHARSRQAEAEQVVQEIQALGQNSHYLMFDVNE 85 Query: 62 EALMTEILHD-----HAIDTVIHFAGLKAVGE----SVQKPLEYYDNNVNGTLRLIS 109 + +IL V+ AGL G + Q E +++G ++ Sbjct: 86 RQTVQQILEQDVEQHGGFYGVVLNAGLTHDGAFPALTDQDWDEVISTSLDGFYNVLK 142 >3O26-A nrPDB Length = 311 Score = 38.6 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 18/84 (21%), Positives = 37/84 (44%), Gaps = 6/84 (7%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE-- 62 VTGG+ IG C QL NG V++ + ++ ++ F + D+ + Sbjct: 17 VTGGNKGIGFEICKQLSSNGIMVVLTCRDVTKGHEAVEKLKNSNHENVVFHQLDVTDPIA 76 Query: 63 --ALMTEILHDH--AIDTVIHFAG 82 + + + + H +D +++ AG Sbjct: 77 TMSSLADFIKTHFGKLDILVNNAG 100 >5B1Y-A nrPDB Length = 270 Score = 38.6 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 26/112 (23%), Positives = 46/112 (41%), Gaps = 10/112 (8%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVII-LDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 LVTGGS IG T ++ + G V+I + + RLG V D+ + Sbjct: 27 LVTGGSRGIGRATVLRFAREGWSVVIAYKSRADLAEKTAEEARRLGSPEAYTVRVDVGDP 86 Query: 63 ALMTEILHDHA-----IDTVIHFAGLKAVG----ESVQKPLEYYDNNVNGTL 105 +TE+ ++ +++ AG+ +G S+ + E N+ G Sbjct: 87 DSVTEMSSRVGELIPHLNVLVNAAGVLQLGGIEETSISEWEETLRVNLTGVY 138 >2UVD-A nrPDB Length = 246 Score = 38.6 bits (88), Expect = 0.004, Method: Composition-based stats. Identities = 30/149 (20%), Positives = 57/149 (38%), Gaps = 16/149 (10%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVII-LDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 LVTG S IG + L + G +V++ V+ I++LG V D+ N Sbjct: 8 LVTGASRGIGRAIAIDLAKQGANVVVNYAGNEQKANEVVDEIKKLGSDAIA-VRADVANA 66 Query: 63 ALMTEILHD-----HAIDTVIHFAGLK----AVGESVQKPLEYYDNNVNG----TLRLIS 109 +T ++ +D +++ AG+ + ++ + N+ G T + Sbjct: 67 EDVTNMVKQTVDVFGQVDILVNNAGVTKDNLLMRMKEEEWDTVINTNLKGVFLCTKAVSR 126 Query: 110 AMRAANVKNFIF-SSSATVYGDQPKIPYV 137 M + +S V G+ + YV Sbjct: 127 FMMRQRHGRIVNIASVVGVTGNPGQANYV 155 >1O89-A nrPDB Length = 345 Score = 38.2 bits (87), Expect = 0.005, Method: Composition-based stats. Identities = 12/71 (16%), Positives = 26/71 (36%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 ++VTG SG +GS L + G+ V+ + ++ + + F E + Sbjct: 171 IVVTGASGGVGSTAVALLHKLGYQVVAVSGRESTHEYLKSLGASRVLPRDEFAESRPLEK 230 Query: 63 ALMTEILHDHA 73 + + Sbjct: 231 QVWAGAIDTVG 241 >2C07-A nrPDB Length = 285 Score = 38.2 bits (87), Expect = 0.005, Method: Composition-based stats. Identities = 44/242 (18%), Positives = 88/242 (36%), Gaps = 16/242 (6%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 LVTG IG L ++ VI + S SV+ I+ G + GD+ + Sbjct: 48 LVTGAGRGIGREIAKMLAKSVSHVICISRTQKSCDSVVDEIKSFGYESSG-YAGDVSKKE 106 Query: 64 LMTEILHDH-----AIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKN 118 ++E+++ +D +++ AG+ ++ + +++ + L + + K Sbjct: 107 EISEVINKILTEHKNVDILVNNAGITRDNLFLRMKNDEWEDVLRTNLNSLFYITQPISKR 166 Query: 119 FIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYF 178 I YG I + Q+ Y SK V L K +I + Sbjct: 167 MIN----NRYGRIINISSIVGLTGNVGQANYSSSKAGVIGFTKSLAKELASRNITV---- 218 Query: 179 NPV--GAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHV 236 N + G S + + I N++ I +G + +A ++ + + V Sbjct: 219 NAIAPGFISSDMTDKISEQIKKNIISNIPAGRMGTPEEVANLACFLSSDKSGYINGRVFV 278 Query: 237 MD 238 +D Sbjct: 279 ID 280 >2EW8-A nrPDB Length = 249 Score = 38.2 bits (87), Expect = 0.005, Method: Composition-based stats. Identities = 24/137 (17%), Positives = 47/137 (34%), Gaps = 17/137 (12%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEAL 64 +TGG+ IG + G D+ I D I L G+ V+ D+ Sbjct: 12 ITGGANGIGRAIAERFAVEGADIAIAD--LVPAPEAEAAIRNL-GRRVLTVKCDVSQPGD 68 Query: 65 MTEILHDH-----AIDTVIHFAG----LKAVGESVQKPLEYYDNNVNGTLRLISA----M 111 + D +++ AG + + ++ + ++ NV+ + A M Sbjct: 69 VEAFGKQVISTFGRCDILVNNAGIYPLIPFDELTFEQWKKTFEINVDSGFLMAKAFVPGM 128 Query: 112 RAANVKNFIFSSSATVY 128 + I ++T Y Sbjct: 129 KRNGWGRIINL-TSTTY 144 >2CDH-G nrPDB Length = 244 Score = 38.2 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 34/136 (25%), Positives = 52/136 (38%), Gaps = 15/136 (11%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVII-LDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 V+VTG S IG + L + G V++ + V IE GG+ TF GD+ Sbjct: 4 VVVTGASRGIGKAIALSLGKAGCKVLVNYARSAKAAEEVSKQIEAYGGQAITF-GGDVSK 62 Query: 62 EALMTEILHD-----HAIDTVIHFAGLK----AVGESVQKPLEYYDNNVNG----TLRLI 108 EA + ++ ID V++ AG+ + + E D N+ G T Sbjct: 63 EADVEAMMKTAIDAWGTIDVVVNNAGITRDTLLIRMKKSQWDEVIDLNLTGVFLCTQAAT 122 Query: 109 SAMRAANVKNFIFSSS 124 M I +S Sbjct: 123 KIMMKKRKGRIINIAS 138 >4NBV-A nrPDB Length = 246 Score = 38.2 bits (87), Expect = 0.006, Method: Composition-based stats. Identities = 29/164 (17%), Positives = 59/164 (35%), Gaps = 26/164 (15%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILD-NLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 ++TG + IG T + ++G V++ D + + + V+ R+E Sbjct: 9 IITGAAAGIGFATAQRFAEDGAIVVLCDVQEARVREAAARLAATGATVSAYRVDVTRRDE 68 Query: 63 --ALMTEILHDHA-IDTVIHFAGL----KAVGESVQKPLEYYDNNVNGTLRLISA----M 111 A++ +L H +D +++ AG+ + + + D N+ G A M Sbjct: 69 VDAMVAAVLAAHQRVDILVNNAGITKDARLAKMTEAQFDAVIDVNLKGVFNCAQAVAGLM 128 Query: 112 RAANVKNFIFSSS-ATVYGDQPKIPYVESFPTGTPQSPYGKSKL 154 + +SS +YG+ + Y SK Sbjct: 129 TEQGKGVILNASSVVGLYGNFGQTN-------------YAASKF 159 >4BO1-A nrPDB Length = 269 Score = 37.8 bits (86), Expect = 0.006, Method: Composition-based stats. Identities = 44/228 (19%), Positives = 76/228 (33%), Gaps = 32/228 (14%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 LVTG S IG ++L + G VI + + ++ G + V D+ ++ Sbjct: 31 LVTGASRGIGQAIALELGRLGAVVIGTATSASGAEKIAETLKANGVEGAGLV-LDVSSDE 89 Query: 64 LMTEIL-----HDHAIDTVIHFAGLK----AVGESVQKPLEYYDNNVNGTLRL----ISA 110 + L H V++ AG+ V + + + N+N RL + Sbjct: 90 SVAATLEHIQQHLGQPLIVVNNAGITRDNLLVRMKDDEWFDVVNTNLNSLYRLSKAVLRG 149 Query: 111 MRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDW 170 M A I S V G Y +K +E L + Sbjct: 150 MTKARWGRIINIGS--VVGAMGNAGQTN----------YAAAKAGLEGFTRALAREVGSR 197 Query: 171 SIALLRYFNPV--GAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLA 216 +I + N V G + E P+ L+ I +G+ + +A Sbjct: 198 AITV----NAVAPGFIDTDMTRELPEAQREALLGQIPLGRLGQAEEIA 241 >5L51-A nrPDB Length = 324 Score = 37.8 bits (86), Expect = 0.006, Method: Composition-based stats. Identities = 39/253 (15%), Positives = 70/253 (27%), Gaps = 82/253 (32%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILDN-LCNSKRSVLPVIERLGGKHPTFV---EGDIR 60 VTG + IG C QL G VI+ + +I+ LG + +V + D+ Sbjct: 20 VTGANKGIGFEICKQLASKGITVILASRDEKRGIEARERLIKELGSEFGDYVVSQQLDVA 79 Query: 61 NEALMTEILHDHAI---------------------------DTV---------------- 77 + A + ++ D V Sbjct: 80 DPASVAALVDFIKTKFGSLDILVNNAGLNGTYMEGDASVLNDYVEAEFKTFQSGAAKTEP 139 Query: 78 IHFAGLKAVGESVQKPLEYYDNNVNGTLRLISA----MRAANVKNFIFSS---SATVY-- 128 H + E+V+ E + N G+ R+ A ++ ++ + S S+ V+ Sbjct: 140 YHPKATGRLVETVEHAKECIETNYYGSKRVTEALIPLLQQSDSPRIVNVSSTLSSLVFQT 199 Query: 129 -----GDQPKIPYVESFPTGT-------------------P--QSPYGKSKLMVEQILTD 162 G + P S Y SK + Sbjct: 200 NEWAKGVFSSEEGLTEEKLEEVLAEFLKDFIDGKQQEKQWPPHFSAYKVSKAALNAYTRI 259 Query: 163 LQKAQPDWSIALL 175 + K P + I + Sbjct: 260 IAKKYPSFRINAV 272 >2Q4B-A nrPDB Length = 253 Score = 37.8 bits (86), Expect = 0.007, Method: Composition-based stats. Identities = 47/261 (18%), Positives = 86/261 (32%), Gaps = 55/261 (21%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 VLVTG SG G +L + G D + L S + E++GG+ F+ GDI + Sbjct: 7 VLVTGASGRTGQIVYKKLKE-GSDKFVAKGLVRSAQGK----EKIGGEADVFI-GDITDA 60 Query: 63 ALMTEILHDHAIDT-VIHFAGLKAVGESVQ-----KPLEYYD-------NNVNGTLRLIS 109 + ID VI + + + +P ++ + G I Sbjct: 61 DSINPAFQ--GIDALVILTSAVPKMKPGFDPTKGGRPEFIFEDGQYPEQVDWIGQKNQID 118 Query: 110 AMRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQ-- 167 A + A VK+ + S + P + KL IL +KA+ Sbjct: 119 AAKVAGVKHIVVVGS------------MGGTNPDHPLN-----KLGNGNILVWKRKAEQY 161 Query: 168 ---PDWSIALLRYFNPV----GAHP------SGDMGEDPQGIPNNLMPYIAQVAVGRRDS 214 ++R + G + D + +P + + A+ ++ Sbjct: 162 LADSGTPYTIIRAGGLLDKEGGVRELLVGKDDELLQTDTKTVPRADVAEVCIQALLFEEA 221 Query: 215 LAIFGNDYPTEDGTG--VRDY 233 + +GT +D+ Sbjct: 222 KNKAFDLGSKPEGTSTPTKDF 242 >3KYB-A nrPDB Length = 390 Score = 37.8 bits (86), Expect = 0.007, Method: Composition-based stats. Identities = 23/106 (21%), Positives = 43/106 (40%), Gaps = 12/106 (11%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILD-------NLCNSKRSVLPVIERLGGKHPTF 54 ++L+ G +G+ G+ QL + GH V I+D N +++ S V+ + G H Sbjct: 5 KILIVG-AGFSGAVIGRQLAEKGHQVHIIDQRDHIGGNSYDARDSETNVMVHVYGPH--I 61 Query: 55 VEGDIRNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNN 100 D NE + I + ++ G+ P+ + N Sbjct: 62 FHTD--NETVWNYINKHAEMMPYVNRVKATVNGQVFSLPINLHTIN 105 >3R3S-A nrPDB Length = 294 Score = 37.8 bits (86), Expect = 0.007, Method: Composition-based stats. Identities = 46/260 (17%), Positives = 86/260 (33%), Gaps = 43/260 (16%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLG---GKHPTFVEGD 58 + LVTGG IG + + G DV I N ++ ++ L G+ + GD Sbjct: 51 KALVTGGDSGIGRAAAIAYAREGADVAI--NYLPAEEEDAQQVKALIEECGRKAVLLPGD 108 Query: 59 IRNEALMTEILHD-----HAIDTVIHFAG-LKAVGE----SVQKPLEYYDNNVNGTLRLI 108 + +E+ ++H +D + AG A+ E + ++ + + NV + Sbjct: 109 LSDESFARSLVHKAREALGGLDILALVAGKQTAIPEIKDLTSEQFQQTFAVNVFALFWIT 168 Query: 109 SAMRAANVK--NFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKA 166 K + I +SS Y P + Y +K + L K Sbjct: 169 QEAIPLLPKGASIITTSSIQAYQPSPHLLD------------YAATKAAILNYSRGLAKQ 216 Query: 167 QPDWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTED 226 + I + N V P + G + +P G++ + G Sbjct: 217 VAEKGIRV----NIVAPGPIWTALQISGGQTQDKIPQF-----GQQTPMKRAGQPAELAP 267 Query: 227 GTGVRDYIHVMDLADGHVVA 246 Y+++ +V A Sbjct: 268 V-----YVYLASQESSYVTA 282 >4IS3-A nrPDB Length = 268 Score = 37.4 bits (85), Expect = 0.010, Method: Composition-based stats. Identities = 32/173 (18%), Positives = 62/173 (35%), Gaps = 20/173 (11%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTF-VEGDIRNE 62 ++TGG+ IG + NG V I + L ++ L + D+ + Sbjct: 29 IITGGTRGIGFAAAKIFIDNGAKVSIFGETQEEVDTALAQLKELYPEEEVLGFAPDLTSR 88 Query: 63 ALMTEILHDHA-----IDTVIHFAGLKAV----GESVQKPLEYYDNNVNGTLR----LIS 109 + + A +D +I+ AG+ + S ++ D NV G Sbjct: 89 DAVMAAVGQVAQKYGRLDVMINNAGITSNNVFSRVSEEEFKHIMDINVTGVFNGAWCAYQ 148 Query: 110 AMRAANVKNFIFSSSAT-VYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILT 161 M+ A I ++S T ++G + Y + S G + + +I+ Sbjct: 149 CMKDAKKGVIINTASVTGIFGSLSGVGYP-----ASKASVIGLTHGLGREIIR 196 >3OEC-A nrPDB Length = 317 Score = 37.0 bits (84), Expect = 0.011, Method: Composition-based stats. Identities = 37/206 (17%), Positives = 66/206 (32%), Gaps = 51/206 (24%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILD--------NLCNSKRSVLPVIERLGGKHPTFV 55 +TG + G V+L Q+G D++ +D + L RL + + Sbjct: 50 FITGAARGQGRTHAVRLAQDGADIVAIDLCRQQPNLDYAQGSPEELKETVRLVEEQGRRI 109 Query: 56 ---EGDIRNEALMTEILHD-----HAIDTVIHFAGLKA----VGESVQKPLEYYDNNVNG 103 + D+R+ A + ++ + ID ++ G+ V + Q+ + N+ G Sbjct: 110 IARQADVRDLASLQAVVDEALAEFGHIDILVSNVGISNQGEVVSLTDQQWSDILQTNLIG 169 Query: 104 TLRLISAMRAANVKN-----FIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQ 158 A+ + ++ IF SS QS Y SK Sbjct: 170 AWHACRAVLPSMIERGQGGSVIFVSS------------TVGLRGAPGQSHYAASK----- 212 Query: 159 ILTDLQKAQPDWSIALLRYFNPVGAH 184 +L N VG H Sbjct: 213 ---------HGVQGLMLSLANEVGRH 229 >3PPI-A nrPDB Length = 281 Score = 37.0 bits (84), Expect = 0.012, Method: Composition-based stats. Identities = 23/124 (18%), Positives = 45/124 (36%), Gaps = 18/124 (14%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 +V+GG+G +G T +L +G V+I D +++ + G FV ++ +E Sbjct: 34 IVSGGAGGLGEATVRRLHADGLGVVIADLAAEKGKALADEL----GNRAEFVSTNVTSED 89 Query: 64 LMTEILH------DHAIDTVIHFA---GLKAVGE-----SVQKPLEYYDNNVNGTLRLIS 109 + + V H + V + + D +NGT + Sbjct: 90 SVLAAIEAANQLGRLRYAVVAHGGFGVAQRIVQRDGSPADMGGFTKTIDLYLNGTYNVAR 149 Query: 110 AMRA 113 + A Sbjct: 150 LVAA 153 >1JAY-A nrPDB Length = 212 Score = 36.6 bits (83), Expect = 0.017, Method: Composition-based stats. Identities = 12/50 (24%), Positives = 23/50 (46%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGK 50 MRV + GG+G +G ++L GH++++ + R+ G Sbjct: 1 MRVALLGGTGNLGKGLALRLATLGHEIVVGSRREEKAEAKAAEYRRIAGD 50 >5D01-A nrPDB Length = 379 Score = 36.3 bits (82), Expect = 0.019, Method: Composition-based stats. Identities = 48/276 (17%), Positives = 92/276 (33%), Gaps = 49/276 (17%) Query: 1 MRVLVT-----GGSGYIGSHTCVQLLQNGHDVI-----ILDNLCNSKRSV-LPVIERLGG 49 +++ +T GGSG I + QL + GH++ I L ++ +E Sbjct: 6 LKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPFRLNTYHPNIHFHEVEVNQY 65 Query: 50 KHPTFVEGDIRNEALMTEILHDHAIDTV-IHFAGLKAVGESVQKPLEYYDNNVNGTLR-- 106 + D+ + + E+ +D + H+A AV + K + + + TL Sbjct: 66 AVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVCAYLAKQMLKRNIGIVTTLHGT 125 Query: 107 ----------LISAMRAA--NVKNFIFSSS---ATVYGDQPKIPYVESFPTGTPQSPYGK 151 L +R A + SS A Y +E+ + Y K Sbjct: 126 DITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETYDLIKPEKKIETIYNFIDERVYLK 185 Query: 152 SKLMV----------EQILTDLQKAQPDWSIA-LLRYF-NPVGAHPSGDM--GEDPQGIP 197 E+++ + + + ++R F N G + + G+ P+ Sbjct: 186 KNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVIRVFRNIAGKTKAKLLLVGDGPEKST 245 Query: 198 N-NLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRD 232 L+ G D + + GN ED + D Sbjct: 246 ACELIR-----KYGLEDQVLMLGNQDRVEDLYSISD 276 >6D9T-A nrPDB Length = 400 Score = 36.3 bits (82), Expect = 0.022, Method: Composition-based stats. Identities = 22/93 (23%), Positives = 43/93 (46%), Gaps = 12/93 (12%) Query: 1 MRVLVT-----GGSGYIGSHTCVQLLQNGHDVI-ILDNLCNSKRSVLPV--IERLGGKHP 52 M++ +T GGSG I + ++L + GH+V I N+ R LP ++ Sbjct: 21 MKIGITCYPSMGGSGIIATELGIKLAERGHEVHFITSNIPFRIRKPLPNMIFHQVEVNQY 80 Query: 53 TFVE---GDIRNEALMTEILHDHAIDTV-IHFA 81 + DI + E++ ++ +D + +H+A Sbjct: 81 AVFQYPPYDITLSTKIAEVIKEYDLDLLHMHYA 113 >5CDY-A nrPDB Length = 244 Score = 35.9 bits (81), Expect = 0.026, Method: Composition-based stats. Identities = 28/126 (22%), Positives = 48/126 (38%), Gaps = 14/126 (11%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 LVTG S IG L++ G VI S++ + LG + ++ + Sbjct: 9 LVTGASRGIGRAIAELLVERGACVIG---TATSEKGAEAISAYLGENGKGLM-LNVVDPT 64 Query: 64 LMTEIL-----HDHAIDTVIHFAGLK----AVGESVQKPLEYYDNNVNGTLRLISA-MRA 113 + +L +D +++ AG+ + + + D N+ RL A MRA Sbjct: 65 SIDTVLATIRAEFGEVDILVNNAGITRDNLLMRMKDDEWQDIIDTNLTSVFRLSKAVMRA 124 Query: 114 ANVKNF 119 K F Sbjct: 125 MMKKRF 130 >3W8F-A nrPDB Length = 260 Score = 35.9 bits (81), Expect = 0.027, Method: Composition-based stats. Identities = 23/138 (16%), Positives = 51/138 (36%), Gaps = 14/138 (10%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSK-RSVLPVIERLGGKHPTFVEGDIR 60 + +VTG + IG +L + G DV+I +E G ++ D+ Sbjct: 6 KAVVTGSTSGIGLAMATELAKAGADVVINGFGQPEDIERERSTLESKFGVKAYYLNADLS 65 Query: 61 NEALMTEILHD-----HAIDTVIHFAGLKAVGESVQKPLEYYD--------NNVNGTLRL 107 + + + +D +++ AG++ + P++ ++ +GT Sbjct: 66 DAQATRDFIAKAAEALGGLDILVNNAGIQHTAPIEEFPVDKWNAIIALNLSAVFHGTAAA 125 Query: 108 ISAMRAANVKNFIFSSSA 125 + M+ I +SA Sbjct: 126 LPIMQKQGWGRIINIASA 143 >1E3W-A nrPDB Length = 261 Score = 35.9 bits (81), Expect = 0.028, Method: Composition-based stats. Identities = 21/122 (17%), Positives = 45/122 (36%), Gaps = 19/122 (15%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEAL 64 +TGG+ +G T +L+ G ++LD + + + G + F ++ +E Sbjct: 15 ITGGASGLGLSTAKRLVGQGATAVLLDVPNSEGETEAKKL----GGNCIFAPANVTSEKE 70 Query: 65 MTEILHDHA-----IDTVIHFAGLKAVGESVQ----------KPLEYYDNNVNGTLRLIS 109 + L ID ++ AG+ ++ + N+ GT +I Sbjct: 71 VQAALTLAKEKFGRIDVAVNCAGIAVAIKTYHEKKNQVHTLEDFQRVINVNLIGTFNVIR 130 Query: 110 AM 111 + Sbjct: 131 LV 132 >3OIC-A nrPDB Length = 258 Score = 35.5 bits (80), Expect = 0.031, Method: Composition-based stats. Identities = 40/188 (21%), Positives = 72/188 (38%), Gaps = 33/188 (17%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLG--GKHPTFVEGDIRN 61 LVTG S +G ++L +NG++++I N SK++ L E + G V+ ++ Sbjct: 8 LVTGSSRGVGKAAAIRLAENGYNIVI--NYARSKKAALETAEEIEKLGVKVLVVKANVGQ 65 Query: 62 EALMTEILHDHA-----IDTVIHFAGLKAVGESVQKPLEYY---DNNVNGTLRLI----S 109 A + E+ +D ++ A V V + E + N+N L+ Sbjct: 66 PAKIKEMFQQIDETFGRLDVFVNNAA-SGVLRPVMELEETHWDWTMNIN-AKALLFCAQE 123 Query: 110 AMR---AANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKA 166 A + + + SS I Y+E++ T G SK +E + L Sbjct: 124 AAKLMEKNGGGHIVSISS------LGSIRYLENYTTV------GVSKAALEALTRYLAVE 171 Query: 167 QPDWSIAL 174 I + Sbjct: 172 LSPKQIIV 179 >4XRR-A nrPDB Length = 456 Score = 35.5 bits (80), Expect = 0.032, Method: Composition-based stats. Identities = 20/95 (21%), Positives = 40/95 (42%), Gaps = 7/95 (7%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 ++V++ G +GY+G+ V L G +V+ +D+ + + RL + G +R Sbjct: 16 LKVVIAG-AGYVGTCLAVTLAGRGAEVVAVDSDPGTVADLRAGRCRLPEPG---LAGAVR 71 Query: 61 NEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLE 95 + A + + D V V +V P + Sbjct: 72 DLAATGRLTASTSYDPV---GAADVVIVTVGTPTD 103 >2B4Q-A nrPDB Length = 276 Score = 35.1 bits (79), Expect = 0.041, Method: Composition-based stats. Identities = 46/229 (20%), Positives = 65/229 (28%), Gaps = 35/229 (15%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 LVTGGS IG LL+ G V I + + G + D+ +EA Sbjct: 33 LVTGGSRGIGQMIAQGLLEAGARVFICARDAEACADTATRLSAYGDCQA--IPADLSSEA 90 Query: 64 LMTEILHDHA-----IDTVIHFAGLK--AVGESV--QKPLEYYDNNVNGTLR-------- 106 + +D +++ AG A ES + NV Sbjct: 91 GARRLAQALGELSARLDILVNNAGTSWGAALESYPVSGWEKVMQLNVTSVFSCIQQLLPL 150 Query: 107 LISAMRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKA 166 L + A N I S G YG SK + Q+ L K Sbjct: 151 LRRSASAENPARVINIGSVA-----------GISAMGEQAYAYGPSKAALHQLSRMLAKE 199 Query: 167 QPDWSIALLRYFNPVGAHPSG-DMGEDPQGIPNNLMPYIAQVAVGRRDS 214 I + N + M P L A + +GR Sbjct: 200 LVGEHINV----NVIAPGRFPSRMTRHIANDPQALEADSASIPMGRWGR 244 >5ER0-A nrPDB Length = 518 Score = 35.1 bits (79), Expect = 0.042, Method: Composition-based stats. Identities = 15/62 (24%), Positives = 24/62 (38%), Gaps = 7/62 (11%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 R+ V G +GYIG+ GHDV ++D + + +E D R+ Sbjct: 199 RITVIG-AGYIGAELAEAYSTTGHDVTLIDAMARVMP------KYFDADFTDVIEQDYRD 251 Query: 62 EA 63 Sbjct: 252 HG 253 >4HP8-A nrPDB Length = 247 Score = 35.1 bits (79), Expect = 0.043, Method: Composition-based stats. Identities = 23/104 (22%), Positives = 39/104 (37%), Gaps = 7/104 (6%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 + LVTG + +G V L G +V+ L +I + GG + D + Sbjct: 11 KALVTGANTGLGQAIAVGLAAAGAEVVCAARRAPD--ETLDIIAKDGGNASALLI-DFAD 67 Query: 62 EALMTEILHDHAIDTVIHFAGLK----AVGESVQKPLEYYDNNV 101 + D D +++ AG+ +V S E D N+ Sbjct: 68 PLAAKDSFTDAGFDILVNNAGIIRRADSVEFSELDWDEVMDVNL 111 >4CR6-A nrPDB Length = 271 Score = 35.1 bits (79), Expect = 0.046, Method: Composition-based stats. Identities = 11/28 (39%), Positives = 16/28 (57%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILD 31 +VTG +G IG T L+ G V+ +D Sbjct: 19 IVTGAAGGIGRATVEAYLREGASVVAMD 46 >3O4R-A nrPDB Length = 261 Score = 34.7 bits (78), Expect = 0.055, Method: Composition-based stats. Identities = 30/165 (18%), Positives = 49/165 (29%), Gaps = 25/165 (15%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVI--ERLGGKHPTFVEGDIRN 61 LVT + IG +L Q+G V++ + + + E L G + Sbjct: 19 LVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAED 78 Query: 62 EALMTEILHD--HAIDTVIHFAGLKAVGESVQKPLE-----YYDNNVNG----TLRLISA 110 + ID ++ A + S+ E D NV T ++ Sbjct: 79 RERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPE 138 Query: 111 MRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLM 155 M + + SS + P SPY SK Sbjct: 139 MEKRGGGSVVIVSSIAAFSPSPG------------FSPYNVSKTA 171 >2PH3-A nrPDB Length = 245 Score = 34.3 bits (77), Expect = 0.070, Method: Composition-based stats. Identities = 45/233 (19%), Positives = 72/233 (30%), Gaps = 36/233 (15%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 + L+TG S IG ++L ++G + I K + R G V G Sbjct: 3 KALITGASRGIGRAIALRLAEDGFALAIHYGQNREKAEEVAEEARRRGSPLVAVLG---- 58 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLI---------SAMR 112 +L A ++H A G L+ NN T + A+ Sbjct: 59 ----ANLLEAEAATALVHQAAEVLGG------LDTLVNNAGITRDTLLVRMKDEDWEAVL 108 Query: 113 AANVKNFIFSSSATV-------YGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQK 165 AN+ ++ V +G I V Q+ Y SK + + K Sbjct: 109 EANLSAVFRTTREAVKLMMKARFGRIVNITSVVGILGNPGQANYVASKAGLIGFTRAVAK 168 Query: 166 AQPDWSIALLRYFNPV--GAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLA 216 I + N V G + PQ + + I GR + +A Sbjct: 169 EYAQRGITV----NAVAPGFIETEMTERLPQEVKEAYLKQIPAGRFGRPEEVA 217 >2CZG-A nrPDB Length = 433 Score = 34.3 bits (77), Expect = 0.075, Method: Composition-based stats. Identities = 12/77 (15%), Positives = 32/77 (41%), Gaps = 10/77 (12%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 ++L+ G SG +G ++ + G +V+ +D N+ + G++ + Sbjct: 21 KILLLG-SGELGKEIAIEAQRLGVEVVAVDRYANAPAMQVAHRS---------YVGNMMD 70 Query: 62 EALMTEILHDHAIDTVI 78 + + ++ D +I Sbjct: 71 KDFLWSVVEREKPDAII 87 >5F5N-A nrPDB Length = 289 Score = 34.3 bits (77), Expect = 0.080, Method: Composition-based stats. Identities = 17/70 (24%), Positives = 26/70 (37%), Gaps = 5/70 (7%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNE 62 +LVTG +G G T LL G V + L + V GD+ ++ Sbjct: 4 ILVTGATGTQGGATVRALLARGRPV-----RALVRDPGTDAARALAAAGVSLVTGDLNDQ 58 Query: 63 ALMTEILHDH 72 A + + D Sbjct: 59 ASLRAAMADV 68 >5T5Q-A nrPDB Length = 247 Score = 33.9 bits (76), Expect = 0.093, Method: Composition-based stats. Identities = 30/176 (17%), Positives = 60/176 (34%), Gaps = 26/176 (14%) Query: 2 RVLV-TGGSGYIGSHTCVQLLQNGHDVIILD---NLCNSKRSVLPVIERLGGKHPTFVEG 57 R LV TG +G IG +G ++++ D ++ + L ER+ Sbjct: 10 RTLVLTGANGGIGRAIAELFHASGANLVLTDLDREGLDAFAASLGSPERIATIKADASSA 69 Query: 58 DIRNEALMTEILHDHAIDTVIHFA----GLKAVGESVQKPLEYYDNNVNGTLRL----IS 109 D + + + ID ++ A S N++G L + Sbjct: 70 DDAEKTVALAMERFGGIDFLVPSAGIYQAKPFAEMSDADWHRTISINLDGVFYLCKRALP 129 Query: 110 AMRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQK 165 A++ + + + +S Y + YV + YG +K + + L + Sbjct: 130 ALKEDS--SIVTLASLAAY----RGAYVNAH--------YGATKGAMVSMTRALSR 171 >5O3Z-A nrPDB Length = 263 Score = 33.9 bits (76), Expect = 0.097, Method: Composition-based stats. Identities = 20/75 (26%), Positives = 31/75 (41%), Gaps = 3/75 (4%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILD-NLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 V GG +G+ C L Q G+ V + D N N+ R + R G + D +EA Sbjct: 11 VIGGGQTLGAFLCEGLAQAGYHVAVADLNESNANRLADTINSRYGAGRAYGFKVDATDEA 70 Query: 64 LMTEILHDHAIDTVI 78 + + A+D Sbjct: 71 SVEALAR--AVDETF 83 >4G65-A nrPDB Length = 461 Score = 33.9 bits (76), Expect = 0.11, Method: Composition-based stats. Identities = 8/32 (25%), Positives = 18/32 (56%), Gaps = 1/32 (3%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDN 32 M++++ G +G +G L+ +D+ I+D Sbjct: 4 MKIIILG-AGQVGGTLAENLVGENNDITIVDK 34 >2X9N-A nrPDB Length = 288 Score = 33.6 bits (75), Expect = 0.12, Method: Composition-based stats. Identities = 16/64 (25%), Positives = 30/64 (46%), Gaps = 5/64 (7%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPT---FVEGDIRN 61 VTG + IG V+L Q G+ V+I + NS + + + + L + + D+ N Sbjct: 28 VTGAAKRIGRAIAVKLHQTGYRVVI--HYHNSAEAAVSLADELNKERSNTAVVCQADLTN 85 Query: 62 EALM 65 ++ Sbjct: 86 SNVL 89 >5OJG-A nrPDB Length = 260 Score = 33.6 bits (75), Expect = 0.14, Method: Composition-based stats. Identities = 29/164 (17%), Positives = 58/164 (35%), Gaps = 26/164 (15%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR--- 60 +VT + IG +LL G V+I + + ++ G + G I Sbjct: 14 IVTAATKGIGLAIAERLLDEGASVVIGSRNQKNVDEAIEYLKNKGLTKVAGIAGHIASTD 73 Query: 61 NEALMTE--ILHDHAIDTVI--HFA--GLKAVGE-SVQKPLEYYDNNVNGTLRLISAMRA 113 ++ + + + I+ ++ H + E S Q + ++ NV ++ + Sbjct: 74 DQKKLVDFTLQKFGKINILVNNHGINPAFGHILEVSDQVWDKLFEVNVKAGFQMTKLVHP 133 Query: 114 ANVK----NFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSK 153 K IF++S + Y P I + YG +K Sbjct: 134 HIAKEGGGAIIFNASYSAYKSPPGI------------AAYGVTK 165 >3ORF-A nrPDB Length = 251 Score = 33.2 bits (74), Expect = 0.16, Method: Composition-based stats. Identities = 29/177 (16%), Positives = 53/177 (29%), Gaps = 13/177 (7%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 +LV GGSG +G+ + I +D N I+ G + V I + Sbjct: 24 NILVLGGSGALGAEVVKFFKSKSWNTISIDFRENPNADHSFTIKDSGEEEIKSVIEKINS 83 Query: 62 EALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIF 121 +++ + V G S + L+ + L SA +A++ + Sbjct: 84 KSIKVDTF-------VCAAGGWSGGNASSDEFLK--SVKGMIDMNLYSAFASAHIGAKLL 134 Query: 122 SSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYF 178 + G + + YG +K I+ DL Sbjct: 135 NQG----GLFVLTGASAALNRTSGMIAYGATKAATHHIIKDLASENGGLPAGSTSLG 187 >2DKN-A nrPDB Length = 255 Score = 33.2 bits (74), Expect = 0.17, Method: Composition-based stats. Identities = 10/30 (33%), Positives = 16/30 (53%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDN 32 + +TG + IG+ L + GH VI +D Sbjct: 4 IAITGSASGIGAALKELLARAGHTVIGIDR 33 >2BGM-A nrPDB Length = 278 Score = 32.8 bits (73), Expect = 0.20, Method: Composition-based stats. Identities = 20/127 (15%), Positives = 42/127 (33%), Gaps = 17/127 (13%) Query: 17 CVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEALMTEIL-----HD 71 ++ G V+I D + + V I +FV D+ + + ++ Sbjct: 33 AKLFVRYGAKVVIADIADDHGQKVCNNIGSPDV--ISFVHCDVTKDEDVRNLVDTTIAKH 90 Query: 72 HAIDTVI-HFAGLKAVGESV-----QKPLEYYDNNVNGTL----RLISAMRAANVKNFIF 121 +D + + L S+ + D NV G M A + +F Sbjct: 91 GKLDIMFGNVGVLSTTPYSILEAGNEDFKRVMDINVYGAFLVAKHAARVMIPAKKGSIVF 150 Query: 122 SSSATVY 128 ++S + + Sbjct: 151 TASISSF 157 >2ZAT-A nrPDB Length = 260 Score = 32.8 bits (73), Expect = 0.21, Method: Composition-based stats. Identities = 27/165 (16%), Positives = 52/165 (31%), Gaps = 25/165 (15%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVI--ERLGGKHPTFVEGDIRN 61 LVT + IG +L Q+G V++ + + + E L G + Sbjct: 18 LVTASTDGIGLAIARRLAQDGAHVVVSSRKQENVDRTVATLQGEGLSVTGTVCHVGKAED 77 Query: 62 EALMTEILHD--HAIDTVIHFAG----LKAVGESVQKPLEYY-DNNVNGTLRLISA---- 110 + + + +D ++ A + ++ ++ + NV T+ + A Sbjct: 78 RERLVAMAVNLHGGVDILVSNAAVNPFFGNIIDATEEVWDKILHVNVKATVLMTKAVVPE 137 Query: 111 MRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLM 155 M + + SS Y P PY SK Sbjct: 138 MEKRGGGSVLIVSSVGAY-----------HPFPN-LGPYNVSKTA 170 >4JRO-A nrPDB Length = 271 Score = 32.8 bits (73), Expect = 0.24, Method: Composition-based stats. Identities = 20/133 (15%), Positives = 42/133 (31%), Gaps = 13/133 (9%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEAL 64 VTGGS IG + L + G ++ N + G ++ ++ Sbjct: 34 VTGGSRGIGRDIAINLAKEGANIFFNYNGSPEAAEETAKLVAEHGVEVEAMKANVAIAED 93 Query: 65 MTEILHD-----HAIDTVIHFAGLK----AVGESVQKPLEYYDNNVNGTL----RLISAM 111 + +D +++ AG+ + + + + N+ GT + M Sbjct: 94 VDAFFKQAIERFGRVDILVNNAGITRDNLLMRMKEDEWDDVININLKGTFLCTKAVSRTM 153 Query: 112 RAANVKNFIFSSS 124 I +S Sbjct: 154 MKQRAGKIINMAS 166 >2BC1-A nrPDB Length = 490 Score = 32.4 bits (72), Expect = 0.25, Method: Composition-based stats. Identities = 16/77 (20%), Positives = 30/77 (38%), Gaps = 17/77 (22%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 RV V G +GYIG + G +V+++D + + + D+ + Sbjct: 196 RVAVVG-AGYIGVELAEAFQRKGKEVVLID--------------VVDTCLAGYYDRDLTD 240 Query: 62 EALMTEILHDHAIDTVI 78 LM + + +H I Sbjct: 241 --LMAKNMEEHGIQLAF 255 >3FTP-A nrPDB Length = 270 Score = 32.4 bits (72), Expect = 0.27, Method: Composition-based stats. Identities = 31/184 (16%), Positives = 61/184 (33%), Gaps = 26/184 (14%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 +VTG S IG ++L + G VI + ++ G + V ++ + Sbjct: 32 IVTGASRGIGRAIALELARRGAMVIGTATTEAGAEGIGAAFKQAGLEGRGAV-LNVNDAT 90 Query: 64 LMTEILHD-----HAIDTVIHFAG----LKAVGESVQKPLEYYDNNVNGTLRLISAMRAA 114 + ++ A++ +++ AG A+ + D N+ RL A+ Sbjct: 91 AVDALVESTLKEFGALNVLVNNAGITQDQLAMRMKDDEWDAVIDTNLKAVFRLSRAVLRP 150 Query: 115 NVK----NFIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDW 170 +K + +S V G V Y +K V + L + Sbjct: 151 MMKARGGRIVNITS--VVGSAGNPGQVN----------YAAAKAGVAGMTRALAREIGSR 198 Query: 171 SIAL 174 I + Sbjct: 199 GITV 202 >3MJ4-A nrPDB Length = 397 Score = 32.4 bits (72), Expect = 0.28, Method: Composition-based stats. Identities = 10/29 (34%), Positives = 17/29 (58%), Gaps = 1/29 (3%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDN 32 L+ G +G+ GS +L +G V+I+D Sbjct: 33 LIVG-AGFAGSVLAERLASSGQRVLIVDR 60 >5OKP-A nrPDB Length = 461 Score = 32.4 bits (72), Expect = 0.31, Method: Composition-based stats. Identities = 7/29 (24%), Positives = 16/29 (55%) Query: 307 DRELNWRVTRTLDEMAQDTWHWQSRHPQG 335 + E+++ T + ++DT+ W + P G Sbjct: 235 EEEISFPPTYRYERGSRDTYAWHKQKPTG 263 >3NR8-B nrPDB Length = 316 Score = 32.4 bits (72), Expect = 0.31, Method: Composition-based stats. Identities = 7/29 (24%), Positives = 16/29 (55%) Query: 307 DRELNWRVTRTLDEMAQDTWHWQSRHPQG 335 + E+++ T + ++DT+ W + P G Sbjct: 236 EEEISFPPTYRYERGSRDTYAWHKQKPTG 264 >2DC1-A nrPDB Length = 236 Score = 32.4 bits (72), Expect = 0.32, Method: Composition-based stats. Identities = 38/214 (17%), Positives = 75/214 (35%), Gaps = 39/214 (18%) Query: 8 GSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEALMTE 67 G G IG L +NG ++ + ++ ++ I+ + E D+ EA + Sbjct: 7 GYGAIGKFLAEWLERNGFEIAAILDVRGEHEKMVRGIDEFLQR-----EMDVAVEAASQQ 61 Query: 68 ILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFSSSATV 127 + D+A + AG+ + S + D + R+ R ++ +S + Sbjct: 62 AVKDYAEKIL--KAGIDLIVLSTG---AFADRDFL--SRVREVCRKTG--RRVYIASGAI 112 Query: 128 YGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNPVGAHPSG 187 G + + S+L +E+I+ +K R F G G Sbjct: 113 GGL---------------DAIFSASEL-IEEIVLTTRKNW--------RQFGRKGVIFEG 148 Query: 188 DMGEDPQGIPNNL-MPYIAQVAVGRRDSLAIFGN 220 E Q P NL + +A G+ + + + Sbjct: 149 SASEAAQKFPKNLNVAATLSIASGKDVKVRLVAD 182 >4RZH-A nrPDB Length = 247 Score = 32.0 bits (71), Expect = 0.33, Method: Composition-based stats. Identities = 25/134 (18%), Positives = 48/134 (35%), Gaps = 13/134 (9%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 LVTG S IG T + L G V++ ++ + G V+ ++ N Sbjct: 10 LVTGASRGIGKATALALAATGMKVVVNYAQSSTAADAVVAEIIANGGEAIAVQANVANAD 69 Query: 64 LMTEILHD-----HAIDTVIHFAGLK----AVGESVQKPLEYYDNNVNG----TLRLISA 110 + +++ ID +++ AG+ + ++ D N+ G T + Sbjct: 70 EVDQLIKTTLDKFSRIDVLVNNAGITRDTLLLRMKLEDWQAVIDLNLTGVFLCTKAVSKL 129 Query: 111 MRAANVKNFIFSSS 124 M I +S Sbjct: 130 MLKQKSGRIINITS 143 >5GXF-A nrPDB Length = 330 Score = 32.0 bits (71), Expect = 0.36, Method: Composition-based stats. Identities = 13/49 (26%), Positives = 20/49 (40%), Gaps = 4/49 (8%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKH 51 VLVTG +G +GS L G++V + + + LG Sbjct: 153 VLVTGAAGGVGSVATAILAHLGYEVAAV----TGRPETADYLTSLGATQ 197 >1P33-A nrPDB Length = 289 Score = 31.6 bits (70), Expect = 0.48, Method: Composition-based stats. Identities = 14/59 (23%), Positives = 23/59 (38%), Gaps = 1/59 (1%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTF-VEGDIRN 61 LVTG + +GS L G+ V + + + S L + V+ D+ N Sbjct: 11 LVTGAAKRLGSSIAEALHAEGYTVCLHYHRSAADASTLAATLNARRPNSAITVQADLSN 69 >3H0K-A nrPDB Length = 178 Score = 31.6 bits (70), Expect = 0.48, Method: Composition-based stats. Identities = 21/79 (26%), Positives = 32/79 (40%), Gaps = 3/79 (3%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSV-LPVIERL--GGKHPTFVEGDI 59 +L+TG G S L + G VI++ ++ + S+ ERL K + GD Sbjct: 3 ILITGMPGSGKSEFAKLLKERGAKVIVMSDVVRKRYSIEAKPGERLMDFAKRLREIYGDG 62 Query: 60 RNEALMTEILHDHAIDTVI 78 L E L D V+ Sbjct: 63 VVARLCVEELGTSNHDLVV 81 >4RZI-B nrPDB Length = 240 Score = 31.6 bits (70), Expect = 0.54, Method: Composition-based stats. Identities = 10/37 (27%), Positives = 17/37 (45%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRS 39 ++VTGG+ IG+ L + G V D + + Sbjct: 11 IVVTGGNRGIGAAIVKLLQEMGAKVAFTDLATDGGNT 47 >3UVE-A nrPDB Length = 286 Score = 31.6 bits (70), Expect = 0.55, Method: Composition-based stats. Identities = 28/126 (22%), Positives = 43/126 (34%), Gaps = 27/126 (21%) Query: 4 LVTGGS-GYIGSHTCVQLLQNGHDVIILDNLCN------------SKRSVLPVIERLGGK 50 VTG + G SH L Q G D+I +D S L L Sbjct: 15 FVTGAARGQGRSHAVR-LAQEGADIIAVDICKPIRAGVVDTAIPASTPEDLAETADLVKG 73 Query: 51 HPTFV---EGDIRNEALMTEILHD-----HAIDTVIHFAGLKAVGE-----SVQKPLEYY 97 H + E D+R+ + + +D ++ AG+ G+ S + E Sbjct: 74 HNRRIVTAEVDVRDYDALKAAVDSGVEQLGRLDIIVANAGIGNGGDTLDKTSEEDWTEMI 133 Query: 98 DNNVNG 103 D N+ G Sbjct: 134 DINLAG 139 >4TRR-A nrPDB Length = 269 Score = 31.2 bits (69), Expect = 0.57, Method: Composition-based stats. Identities = 25/99 (25%), Positives = 40/99 (40%), Gaps = 11/99 (11%) Query: 5 VTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEAL 64 VTG + IG ++L + G V I D + +V I + GGK V D+ NE Sbjct: 19 VTGAASGIGKEIALELAKAGAAVAIADLNQDGANAVADEINKAGGKAIG-VAMDVTNEEA 77 Query: 65 MTEILHDHA-----IDTVIHFAGLKAVGESVQKPLEYYD 98 + + A +D ++ G + P+E Y Sbjct: 78 VNTGIDKVAEAFGSVDILV-----SNAGIQIVNPIENYS 111 >2YV2-A nrPDB Length = 297 Score = 31.2 bits (69), Expect = 0.63, Method: Composition-based stats. Identities = 11/27 (40%), Positives = 15/27 (55%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVI 28 RVLV G +G GS +L+ G V+ Sbjct: 15 RVLVQGITGREGSFHAKAMLEYGTKVV 41 >5DBI-A nrPDB Length = 374 Score = 31.2 bits (69), Expect = 0.70, Method: Composition-based stats. Identities = 46/313 (14%), Positives = 92/313 (29%), Gaps = 34/313 (10%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 LV G +G +GS +L+ + R PV L K +++ D+ + Sbjct: 8 LVVGVTGIVGSSLAE-VLKLPDTPGGPWKVYGVARRPCPVW--LAKKPVEYIQCDVSDNQ 64 Query: 64 LMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTL-----RLISAMRAANVKN 118 L + H + +G + N+ ++ L +K+ Sbjct: 65 ETISKLSPLK--DITHIFYVSWIGSEDCQTNATMFKNILNSVIPNASNLQHVCLQTGIKH 122 Query: 119 F--IFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLR 176 + IF + V P+ E P + Y +E IL + + + + + ++ R Sbjct: 123 YFGIFEEGSKV--VPHDSPFTEDLPRLNVPNFYHD----LEDILYE-ETGKNNLTWSVHR 175 Query: 177 YFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPTEDGTGVRDYIHV 236 G P M N++ + A + D + Sbjct: 176 PALVFGFSPCSMM---------NIVSTLCVYATICKHENKALVYPGSKNSWNCYADAVDA 226 Query: 237 MDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFAPRREGDL 296 +A+ + A + K + N G + ++ G EG Sbjct: 227 DLVAEHEIWAA--VDPKAKNQVLNCNNGDVFKWKHIWKKLAEEFG----IEMVGYVEGKE 280 Query: 297 PAYWADASKADRE 309 A+ K + Sbjct: 281 QVSLAELMKDKDQ 293 >2G17-A nrPDB Length = 337 Score = 30.9 bits (68), Expect = 0.78, Method: Composition-based stats. Identities = 15/85 (17%), Positives = 31/85 (36%), Gaps = 6/85 (7%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEG--- 57 + L+ G SGY G+ + ++ H I + +I L + V+ Sbjct: 5 LNTLIVGASGYAGAELVSYVNRHPHMTITALTVSAQSNDAGKLISDLHPQLKGIVDLPLQ 64 Query: 58 ---DIRNEALMTEILHDHAIDTVIH 79 D+R+ + +++ V H Sbjct: 65 PMSDVRDFSADVDVVFLATAHEVSH 89 >4DMM-A nrPDB Length = 269 Score = 30.9 bits (68), Expect = 0.95, Method: Composition-based stats. Identities = 17/84 (20%), Positives = 30/84 (35%), Gaps = 5/84 (5%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 LVTG S IG ++L G V + + G V+ D+ E+ Sbjct: 32 LVTGASRGIGRAIALELAAAGAKVAVNYASSAGAADEVVAAIAAAGGEAFAVKADVSQES 91 Query: 64 LMTEILHDH-----AIDTVIHFAG 82 + + +D +++ AG Sbjct: 92 EVEALFAAVIERWGRLDVLVNNAG 115 >2JJM-A nrPDB Length = 394 Score = 30.5 bits (67), Expect = 1.0, Method: Composition-based stats. Identities = 31/164 (18%), Positives = 57/164 (34%), Gaps = 19/164 (11%) Query: 1 MRVLVT-----GGSGYIGSHTCVQLLQNGHDVI-ILDNLCNSKRSVLPVI--ERLGGKHP 52 +++ +T GGSG +G+ QL + GH++ I L V P I + Sbjct: 16 LKIGITCYPSVGGSGVVGTELGKQLAERGHEIHFITSGLPFRLNKVYPNIYFHEVTVNQY 75 Query: 53 TFVE---GDIRNEALMTEILHDHAIDTV-IHFAGLKAVGESVQKPLEYYDNNVNGTLRLI 108 + + D+ + M E+ +D + +H+A A+ + K + + TL Sbjct: 76 SVFQYPPYDLALASKMAEVAQRENLDILHVHYAIPHAICAYLAKQMIGERIKIVTTLHGT 135 Query: 109 SAM------RAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQ 146 N+ F S V + E+ P Sbjct: 136 DITVLGSDPSLNNLIRFGIEQSDVVTAVSHSL-INETHELVKPN 178 >2ZCU-A nrPDB Length = 286 Score = 30.5 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 24/124 (19%), Positives = 46/124 (37%), Gaps = 25/124 (20%) Query: 3 VLVTGGSGYIGSHTCVQLLQ---NGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDI 59 + +TG +G +G + L++ V I+ N + + L + T + D Sbjct: 2 IAITGATGQLGHYVIESLMKTVPASQIVAIVRNPAKA--------QALAAQGITVRQADY 53 Query: 60 RNEALMTEILHDHAIDTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNF 119 +EA +T L V + + + P +I+A +AA VK Sbjct: 54 GDEAALTSALQG-----VEKLLLISSSEVGQRAPQH---------RNVINAAKAAGVKFI 99 Query: 120 IFSS 123 ++S Sbjct: 100 AYTS 103 >5NUE-A nrPDB Length = 332 Score = 30.5 bits (67), Expect = 1.2, Method: Composition-based stats. Identities = 9/16 (56%), Positives = 10/16 (62%) Query: 2 RVLVTGGSGYIGSHTC 17 RVLVTG +G IG Sbjct: 7 RVLVTGAAGQIGYALV 22 >2EXX-A nrPDB Length = 306 Score = 30.1 bits (66), Expect = 1.3, Method: Composition-based stats. Identities = 15/65 (23%), Positives = 29/65 (44%), Gaps = 6/65 (9%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGH-DVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 V+V GG+G G LL++G V ++ ++ + L + V+GD + Sbjct: 14 VVVFGGTGAQGGSVARTLLEDGTFKVRVV-----TRNPRKKAAKELRLQGAEVVQGDQDD 68 Query: 62 EALMT 66 + +M Sbjct: 69 QVIME 73 >2PV7-A nrPDB Length = 298 Score = 30.1 bits (66), Expect = 1.5, Method: Composition-based stats. Identities = 9/31 (29%), Positives = 17/31 (54%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDN 32 ++++ GG G +G L +G+ + ILD Sbjct: 23 KIVIVGGYGKLGGLFARYLRASGYPISILDR 53 >3TQF-A nrPDB Length = 181 Score = 30.1 bits (66), Expect = 1.6, Method: Composition-based stats. Identities = 22/100 (22%), Positives = 43/100 (43%), Gaps = 15/100 (15%) Query: 1 MRVLVTGGSGYIG-SHTCVQLLQNGHDVI---ILDNLCNSKRSVLPVIERLGGKHPTFVE 56 M VL+TG + IG S + L+ GH ++ ++D + + L G P+ Sbjct: 17 MGVLITGEAN-IGKSELSLALIDRGHQLVCDDVIDLKQENNQ--------LIGSCPSVAN 67 Query: 57 GDIRNEAL-MTEILHDHAIDTVIHFAGLKAVGESVQKPLE 95 G I + + ++ +D V++ + S+ KP + Sbjct: 68 GYILITGIGIIDVPKLFGLDAVVNQ-HEVHLSISLVKPEK 106 >1MV8-A nrPDB Length = 436 Score = 29.7 bits (65), Expect = 1.7, Method: Composition-based stats. Identities = 12/35 (34%), Positives = 18/35 (51%), Gaps = 1/35 (2%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCN 35 MR+ + G GY+G+ L GH+VI +D Sbjct: 1 MRISIFGL-GYVGAVCAGCLSARGHEVIGVDVSST 34 >1DIR-A nrPDB Length = 241 Score = 29.7 bits (65), Expect = 1.7, Method: Composition-based stats. Identities = 21/81 (25%), Positives = 35/81 (43%), Gaps = 4/81 (4%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRN 61 RVLV GG G +GS V +D + N + S +++ F E + Sbjct: 9 RVLVYGGRGALGSRCVQAFRARNWWVASIDVVENEEASASVIVKMTDS----FTEQADQV 64 Query: 62 EALMTEILHDHAIDTVIHFAG 82 A + ++L D +D ++ AG Sbjct: 65 TAEVGKLLGDQKVDAILCVAG 85 >5GZU-A nrPDB Length = 885 Score = 29.7 bits (65), Expect = 1.8, Method: Composition-based stats. Identities = 17/107 (15%), Positives = 32/107 (29%), Gaps = 8/107 (7%) Query: 230 VRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVNAFSKACGKPVNYHFA 289 R +++V ++ G A PG YN + D Y + Sbjct: 772 ARGWVNVPNINHGLFQQAGDQAKNPGTPTYND---LVKDYFDKGYTRYWDNSAKAPYLYN 828 Query: 290 PRREGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHW-QSRHPQG 335 P G + D + L ++ ++ + W S+ G Sbjct: 829 PDANGGTFITYDD----EESLKYKAEYAKNQGLRGVMFWDYSQDISG 871 >4R16-A nrPDB Length = 418 Score = 29.7 bits (65), Expect = 1.8, Method: Composition-based stats. Identities = 24/104 (23%), Positives = 36/104 (34%), Gaps = 15/104 (14%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDI- 59 MR+ V G GYIG T + +G+DV+ D VI+++ +E +I Sbjct: 1 MRIAVLGL-GYIGLPTAIMFASSGYDVVGYDIRS-------EVIKKINSGVAHIIEPEID 52 Query: 60 RNEALMTEILHDHAIDTVIHFAG------LKAVGESVQKPLEYY 97 R + + D V G S P Y Sbjct: 53 RRLKEVLSLGKLKVTDRVEDLKGSNVFIICVQTPLSGDDPDLSY 96 >4UUP-A nrPDB Length = 341 Score = 29.7 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 7/20 (35%), Positives = 12/20 (60%) Query: 3 VLVTGGSGYIGSHTCVQLLQ 22 VL+TG +G IG ++ + Sbjct: 7 VLITGAAGQIGYALAFRIAK 26 >5ENV-A nrPDB Length = 347 Score = 29.7 bits (65), Expect = 2.1, Method: Composition-based stats. Identities = 8/30 (26%), Positives = 15/30 (50%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDN 32 V ++G +G +GS G+ V+ +D Sbjct: 173 VAISGAAGGLGSLAVQYAKAMGYRVLGIDG 202 >1LSS-A nrPDB Length = 140 Score = 29.3 bits (64), Expect = 2.2, Method: Composition-based stats. Identities = 9/31 (29%), Positives = 18/31 (58%), Gaps = 1/31 (3%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILD 31 M +++ G G +G L + GHD++++D Sbjct: 5 MYIIIAGI-GRVGYTLAKSLSEKGHDIVLID 34 >1VRD-A nrPDB Length = 494 Score = 29.3 bits (64), Expect = 2.4, Method: Composition-based stats. Identities = 15/63 (23%), Positives = 28/63 (44%), Gaps = 3/63 (4%) Query: 17 CVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTF--VEGDIRNEALMTEILHDHAI 74 +L++ G DVI++D R V+ +E + +P V G++ ++ A Sbjct: 242 VEKLVKAGVDVIVIDTAHGHSRRVIETLEMIKADYPDLPVVAGNVATPEGTEALIKAGA- 300 Query: 75 DTV 77 D V Sbjct: 301 DAV 303 >5B37-A nrPDB Length = 361 Score = 29.3 bits (64), Expect = 2.4, Method: Composition-based stats. Identities = 12/63 (19%), Positives = 22/63 (34%), Gaps = 1/63 (1%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIR 60 M+V V G G +G + C L ++ + + D V + + D+ Sbjct: 170 MKVAVQGL-GNVGKNLCRHLHEHDVQLFVSDVDPIKAEEVKRLFGATVVEPTEIYSLDVD 228 Query: 61 NEA 63 A Sbjct: 229 IFA 231 >4UUO-A nrPDB Length = 340 Score = 29.3 bits (64), Expect = 2.7, Method: Composition-based stats. Identities = 6/20 (30%), Positives = 12/20 (60%) Query: 3 VLVTGGSGYIGSHTCVQLLQ 22 +L+TG +G IG ++ + Sbjct: 6 ILITGAAGQIGYALTFRIAK 25 >4UUM-A nrPDB Length = 341 Score = 28.9 bits (63), Expect = 2.8, Method: Composition-based stats. Identities = 8/22 (36%), Positives = 13/22 (59%), Gaps = 1/22 (4%) Query: 3 VLVTGGSGYIGSHTCVQLLQNG 24 VL+TG +G IG + + +G Sbjct: 7 VLITGAAGQIG-YILSHWIASG 27 >1YB2-A nrPDB Length = 275 Score = 28.9 bits (63), Expect = 2.8, Method: Composition-based stats. Identities = 18/79 (22%), Positives = 31/79 (39%), Gaps = 7/79 (8%) Query: 1 MRVLVTG-GSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDI 59 M +L G GSG + S+ L G ++ + N K+++ + E + DI Sbjct: 112 MDILEVGVGSGNMSSYILYALNGKGTLTVVERDEDNLKKAMDNLSEFYDIGNVRTSRSDI 171 Query: 60 RNEALMTEILHDHAIDTVI 78 + + D D VI Sbjct: 172 ADF------ISDQMYDAVI 184 >2VK2-A nrPDB Length = 306 Score = 28.9 bits (63), Expect = 3.0, Method: Composition-based stats. Identities = 23/148 (15%), Positives = 48/148 (32%), Gaps = 14/148 (9%) Query: 153 KLMVEQILTDLQKAQPDWSIALLRYFNPVGAHPSGDMGEDPQGIPNN-----LMPYIAQV 207 KL+ + ++ ++ ++ VGA + D + N ++ + Sbjct: 114 KLIGDWLVKEVN----GKPCNVVELQGTVGASVAIDRKKGFAEAIKNAPNIKIIRSQSGD 169 Query: 208 AVGRRDSLAIFGNDYPTEDGTGV-RDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVG 266 + + +G + Y H D+ G + A+++ KPG I G Sbjct: 170 FTRSKGKEVMESFIKAENNGKNICMVYAHNDDMVIGAIQAIKEAGLKPGKDIL---TGSI 226 Query: 267 NSVLDVVNAFSKACGKPVNYHFAPRREG 294 + V D+ A + P G Sbjct: 227 DGVPDIYKAMMDGEAN-ASVELTPNMAG 253 >1X1H-A nrPDB Length = 752 Score = 28.9 bits (63), Expect = 3.0, Method: Composition-based stats. Identities = 13/81 (16%), Positives = 26/81 (32%), Gaps = 4/81 (4%) Query: 156 VEQILTDLQKAQPDWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRDSL 215 +++ D D ++ R + +G +A VG Sbjct: 32 TDKLAQDANDYWEDMDLSSSRTYIWYALRGNGTSDNVNAVYERLRTMALAATTVGSS--- 88 Query: 216 AIFGNDYPTEDGTGVRDYIHV 236 ++GN ED D+++V Sbjct: 89 -LYGNADLKEDILDALDWLYV 108 >4A10-A nrPDB Length = 447 Score = 28.9 bits (63), Expect = 3.1, Method: Composition-based stats. Identities = 19/100 (19%), Positives = 37/100 (37%), Gaps = 12/100 (12%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTF-VEGDIRN 61 VL+ G SG +GS+ + G + + + + +V + L + DI + Sbjct: 224 VLIWGASGGLGSYAIQFVKNGGGIPVAVVSSAQKEAAVRALGCDLVINRAELGITDDIAD 283 Query: 62 E--------ALMTEILHDHA---IDTVIHFAGLKAVGESV 90 + + +++ + A D V G G SV Sbjct: 284 DPRRVVETGRKLAKLVVEKAGREPDIVFEHTGRVTFGLSV 323 >1FUI-A nrPDB Length = 591 Score = 28.9 bits (63), Expect = 3.1, Method: Composition-based stats. Identities = 8/36 (22%), Positives = 14/36 (38%), Gaps = 3/36 (8%) Query: 300 WADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQG 335 AD + + L + + Q HW ++P G Sbjct: 280 LADIGRVEESLGYNA---IAAGFQGQRHWTDQYPNG 312 >4TVO-A nrPDB Length = 330 Score = 28.9 bits (63), Expect = 3.4, Method: Composition-based stats. Identities = 8/20 (40%), Positives = 12/20 (60%) Query: 1 MRVLVTGGSGYIGSHTCVQL 20 ++V VTG +G IG +L Sbjct: 6 LKVAVTGAAGQIGYSLLFRL 25 >5DT9-A nrPDB Length = 387 Score = 28.5 bits (62), Expect = 3.7, Method: Composition-based stats. Identities = 13/67 (19%), Positives = 22/67 (32%), Gaps = 19/67 (28%) Query: 8 GSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEALMTE 67 G+G +GS+ L G V++ D P +GD R + Sbjct: 130 GAGQVGSYLAKCLSGIGMKVLLND-------------------PPKQAQGDEREFTELET 170 Query: 68 ILHDHAI 74 +L + Sbjct: 171 LLKQADV 177 >1DXY-A nrPDB Length = 333 Score = 28.5 bits (62), Expect = 3.7, Method: Composition-based stats. Identities = 18/114 (15%), Positives = 38/114 (33%), Gaps = 18/114 (15%) Query: 8 GSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEALMTE 67 G+G+IG G VI D + G HP F + + ++ Sbjct: 152 GTGHIGQVAIKLFKGFGAKVIAYDPY------------PMKGDHPDFDYVSLEDLFKQSD 199 Query: 68 ILHDHAI-----DTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANV 116 ++ H +I+ A + + N+ T ++S +++ + Sbjct: 200 VIDLHVPGIEQNTHIINEAAFNLMKP-GAIVINTARPNLIDTQAMLSNLKSGKL 252 >1W73-A nrPDB Length = 302 Score = 28.5 bits (62), Expect = 3.7, Method: Composition-based stats. Identities = 31/214 (14%), Positives = 63/214 (29%), Gaps = 18/214 (8%) Query: 20 LLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEALMTEILHD-----HAI 74 L G +I + ++ I G ++ D+R+ ++ + + Sbjct: 46 LSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVRDPDMVQNTVSELIKVAGHP 105 Query: 75 DTVIHFAGLKAVGESVQKPLEYYDNNVNGTLRLISAMRAANVKNFIFSSSATVYGDQPKI 134 + VI+ A + + + + + L + + K I + + I Sbjct: 106 NIVINNAAGNFISPTERLSPNAWKTITDIVLNGTAFVTLEIGKQLIKAQKGAAFLSITTI 165 Query: 135 PYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPDWSIALLRYFNPVGAHPSGDMGE--- 191 P +K VE + L + + FN + P G Sbjct: 166 YAETGSGFVVPS---ASAKAGVEAMSKSLAAEWGKYGMR----FNVIQPGPIKTKGAFSR 218 Query: 192 -DPQGIPNNLMPYIAQVAVGRRDSLAIFGNDYPT 224 DP G M I ++ GR ++ N Sbjct: 219 LDPTGTFEKEM--IGRIPCGRLGTVEELANLAAF 250 >1VIM-A nrPDB Length = 200 Score = 28.5 bits (62), Expect = 3.8, Method: Composition-based stats. Identities = 9/30 (30%), Positives = 16/30 (53%), Gaps = 2/30 (6%) Query: 3 VLVTGG--SGYIGSHTCVQLLQNGHDVIIL 30 + V G SGYI ++L+ G+ V ++ Sbjct: 50 IFVIGAGRSGYIAKAFAMRLMHLGYTVYVV 79 >6ACF-A nrPDB Length = 367 Score = 28.5 bits (62), Expect = 4.3, Method: Composition-based stats. Identities = 15/72 (20%), Positives = 26/72 (36%), Gaps = 2/72 (2%) Query: 2 RVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTF--VEGDI 59 +V+ G G + H C L + G +I+ D + + VE DI Sbjct: 174 KVVAVQGVGNVAYHLCRHLHEEGAKLIVTDINKEAVARAVEEFGAKAVDPNDIYGVECDI 233 Query: 60 RNEALMTEILHD 71 + I++D Sbjct: 234 FAPCALGGIIND 245 >5N2I-A nrPDB Length = 232 Score = 28.5 bits (62), Expect = 4.4, Method: Composition-based stats. Identities = 10/46 (21%), Positives = 19/46 (41%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIER 46 + + V GG+G G + GH+VI+ ++V + Sbjct: 20 LSIAVLGGTGDQGRGLARRFAMAGHEVILGSRSAERAQAVAAELGE 65 >1IE3-A nrPDB Length = 312 Score = 28.5 bits (62), Expect = 4.6, Method: Composition-based stats. Identities = 8/23 (34%), Positives = 11/23 (47%) Query: 1 MRVLVTGGSGYIGSHTCVQLLQN 23 M+V V G +G IG + L Sbjct: 1 MKVAVLGAAGGIGQALALLLKTQ 23 >5O7H-B nrPDB Length = 167 Score = 28.2 bits (61), Expect = 4.8, Method: Composition-based stats. Identities = 9/35 (25%), Positives = 14/35 (40%) Query: 122 SSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMV 156 SS+ VY + +++ P YG SK Sbjct: 131 SSTGQVYRKFFEFSDIQAHPLDGEFDSYGLSKTAT 165 >4E0B-A nrPDB Length = 313 Score = 28.2 bits (61), Expect = 5.7, Method: Composition-based stats. Identities = 12/34 (35%), Positives = 17/34 (50%), Gaps = 3/34 (8%) Query: 1 MRVLVTGGSGYIGSHTCVQL---LQNGHDVIILD 31 M+V V G +G IG + L L G D+ + D Sbjct: 4 MKVAVIGAAGGIGQALALLLKNRLPAGSDLALYD 37 >4LDX-A nrPDB Length = 363 Score = 28.2 bits (61), Expect = 5.8, Method: Composition-based stats. Identities = 6/38 (15%), Positives = 15/38 (39%) Query: 111 MRAANVKNFIFSSSATVYGDQPKIPYVESFPTGTPQSP 148 + N++ + VY +P ++ +P +P Sbjct: 75 CKVINIQRRAEPETDEVYAQITLLPELDQSEPTSPDAP 112 >4M8S-A nrPDB Length = 248 Score = 27.8 bits (60), Expect = 6.8, Method: Composition-based stats. Identities = 26/137 (18%), Positives = 49/137 (35%), Gaps = 22/137 (16%) Query: 4 LVTGGSGYIGSHTCVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEA 63 LVTG S IG+ L G VI + ++ + + GG EG + N A Sbjct: 12 LVTGASRGIGAAIADTLAAAGAKVIGTATSESGAAAISERLAQWGG------EGRVLNSA 65 Query: 64 L---MTEILHDH-----AIDTVIHFAGLK----AVGESVQKPLEYYDNNVNGTLR----L 107 + ++ D +D +++ AG+ + ++ + N+ R + Sbjct: 66 EPETVENLIADIEKTFGKLDILVNNAGITRDNLLMRMKEEEWDDIMQVNLKSVFRASKAV 125 Query: 108 ISAMRAANVKNFIFSSS 124 + M I +S Sbjct: 126 LRGMMKQRAGRIINITS 142 >4D3V-A nrPDB Length = 366 Score = 27.8 bits (60), Expect = 6.9, Method: Composition-based stats. Identities = 22/107 (20%), Positives = 32/107 (29%), Gaps = 7/107 (6%) Query: 217 IFGNDYPTEDGTGVRDYIHVMDLADGHVVAMEKLANKPGVHIYNLGAGVGNSVLDVVN-A 275 +F N D VR V D H+ G +++ N Sbjct: 73 LFWNSLNVIDRRDVRTKEEVRDALFHHIETATNNGKIRPTITIFPPEEKGEKQVEIWNHQ 132 Query: 276 FSKACGKPVNYHFAPRREGDLPAYWADASKADRELNWRVTRTLDEMA 322 + G Y R GD + + A EL WR RT ++ Sbjct: 133 LIRYAG----YESDGERIGDPASCSL--TAACEELGWRGERTDFDLL 173 >3ATQ-A nrPDB Length = 453 Score = 27.8 bits (60), Expect = 7.4, Method: Composition-based stats. Identities = 11/31 (35%), Positives = 19/31 (61%), Gaps = 1/31 (3%) Query: 3 VLVTGGSGYIGSHTCVQLLQNGHDVIILDNL 33 VL+ GG G+ GS QL + G ++++D+ Sbjct: 9 VLIIGG-GFAGSSAAYQLSRRGLKILLVDSK 38 >5UQG-A nrPDB Length = 406 Score = 27.4 bits (59), Expect = 8.5, Method: Composition-based stats. Identities = 13/63 (20%), Positives = 29/63 (46%), Gaps = 3/63 (4%) Query: 17 CVQLLQNGHDVIILDNLCNSKRSVLPVIERLGGKHPT--FVEGDIRNEALMTEILHDHAI 74 L++ G DV++LD+ + ++ ++ + K+P + G+I A + + Sbjct: 151 VDALVEAGVDVVVLDSAHGHSKGIIDTVKAIKAKYPNLDLIAGNIATAAAAKALCEA-GV 209 Query: 75 DTV 77 D V Sbjct: 210 DAV 212 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.129 0.344 Lambda K H 0.267 0.0395 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,997,174 Number of Sequences: 36641 Number of extensions: 497180 Number of successful extensions: 2431 Number of sequences better than 10.0: 253 Number of HSP's better than 10.0 without gapping: 202 Number of HSP's successfully gapped in prelim test: 142 Number of HSP's that attempted gapping in prelim test: 1881 Number of HSP's gapped (non-prelim): 359 length of query: 338 length of database: 10,336,785 effective HSP length: 98 effective length of query: 240 effective length of database: 6,745,967 effective search space: 1619032080 effective search space used: 1619032080 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 59 (27.4 bits)