BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P08842 (583 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1P49-A nrPDB 1170 0.0 3ED4-A nrPDB 185 4e-47 4FDJ-A nrPDB 154 1e-37 1E2S-P nrPDB 143 2e-34 1FSU-A nrPDB 127 1e-29 6BIA-A nrPDB 114 2e-25 4CXU-A nrPDB 100 3e-21 5G2V-A nrPDB 93 3e-19 6IOZ-A nrPDB 92 6e-19 2QZU-A nrPDB 82 6e-16 4UPL-A nrPDB 69 6e-12 2W8S-A nrPDB 67 2e-11 2VQR-A nrPDB 65 8e-11 4UPI-A nrPDB 63 4e-10 4UPK-A nrPDB 59 5e-09 4UG4-A nrPDB 59 6e-09 4UPH-A nrPDB 54 2e-07 5G2T-A nrPDB 51 1e-06 4MHX-A nrPDB 47 3e-05 3LXQ-A nrPDB 42 0.001 5XWI-A nrPDB 32 0.80 2ZQB-A nrPDB 31 1.6 4JCQ-A nrPDB 29 5.9 >1P49-A nrPDB Length = 562 Score = 1170 bits (3026), Expect = 0.0, Method: Compositional matrix adjust. Identities = 561/562 (99%), Positives = 561/562 (99%) Query: 22 HAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAA 81 HAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPL TPSRAA Sbjct: 1 HAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLATPSRAA 60 Query: 82 FMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSC 141 FMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSC Sbjct: 61 FMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSC 120 Query: 142 HSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLA 201 HSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLA Sbjct: 121 HSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLA 180 Query: 202 ALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLT 261 ALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLT Sbjct: 181 ALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLT 240 Query: 262 QRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQ 321 QRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQ Sbjct: 241 QRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQ 300 Query: 322 ILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGI 381 ILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGI Sbjct: 301 ILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGI 360 Query: 382 LRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEF 441 LRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEF Sbjct: 361 LRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEF 420 Query: 442 LFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPL 501 LFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPL Sbjct: 421 LFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPL 480 Query: 502 LFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQL 561 LFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQL Sbjct: 481 LFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQL 540 Query: 562 CCPSTGLSCQCDREKQDKRLSR 583 CCPSTGLSCQCDREKQDKRLSR Sbjct: 541 CCPSTGLSCQCDREKQDKRLSR 562 >3ED4-A nrPDB Length = 502 Score = 185 bits (470), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 137/455 (30%), Positives = 212/455 (46%), Gaps = 98/455 (21%) Query: 19 AESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPS 78 A + A +PN++++MADDLG GD YG++ ++TPNIDRLA GVK T + A +PL +PS Sbjct: 20 ALAAEAKQPNLVIIMADDLGYGDLATYGHQIVKTPNIDRLAQEGVKFTDYYAPAPLSSPS 79 Query: 79 RAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLG 138 RA +TGR P R+G+ SW +G + L +E+T A LLK QGY TA++GK HL Sbjct: 80 RAGLLTGRMPFRTGIRSWIPSGKDV------ALGRNELTIANLLKAQGYDTAMMGKLHL- 132 Query: 139 MSCHSKTDFCHHPLHH--GFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVT 196 ++ D P GF+Y SL N T GF + T Sbjct: 133 ---NAGGDRTDQPQAQDMGFDY----SLAN------------TAGF---------VTDAT 164 Query: 197 LLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMS 256 L G+++ G+L +P P + Sbjct: 165 LDNAKERPRYGMVYP-------------------TGWLRNGQP-------------TPRA 192 Query: 257 YDNLTQRLTVEAAQFIQRNTET-PFLLVLSYLHVHTALFSSK------------------ 297 + ++ E ++ ++ PF L +++ VH+ L S K Sbjct: 193 DKMSGEYVSSEVVNWLDNKKDSKPFFLYVAFTEVHSPLASPKKYLDMYSQYMSAYQKQHP 252 Query: 298 -----DFAGKSQHGV--YGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEV 350 D+A K GV Y + +D VG++L+ + + ++T++ FTSD G E Sbjct: 253 DLFYGDWADKPWRGVGEYYANISYLDAQVGKVLDKIKAMGEEDNTIVIFTSDNGPVTREA 312 Query: 351 SSKGEIH--GGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVA 408 E++ G ++G+ +G K N WEGGIRVP I+++ + + G D P +D PT+A Sbjct: 313 RKVYELNLAGETDGL-RGRKDNLWEGGIRVPAIIKYGKHLPQGMVSDTPVYGLDWMPTLA 371 Query: 409 KLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLF 443 K+ LP DR DG L+P+LE K+ + + +F Sbjct: 372 KMMNFKLPTDRTFDGESLVPVLEQKALKREKPLIF 406 >4FDJ-A nrPDB Length = 502 Score = 154 bits (388), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 109/315 (34%), Positives = 156/315 (49%), Gaps = 19/315 (6%) Query: 259 NLTQRLTVEAAQFIQRNTET-PFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDW 317 NLTQ EA FI+R PF L + H +++SK F G SQ G YGDAV E+D Sbjct: 178 NLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDD 237 Query: 318 SVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIR 377 S+G+IL LL +L +A++T ++FTSD GA + + GGSNG + GK +EGG+R Sbjct: 238 SIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQ----GGSNGPFLCGKQTTFEGGMR 293 Query: 378 VPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMP-LLEGKSQR 436 P + WP + AGQ + S MD+F T LAG P DR IDG +L+P LL+G+ Sbjct: 294 EPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLM- 352 Query: 437 SDHEFLFHYCNAYLNAV----RWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGS 492 D ++ + + A + H T+ W+ F +F P + TH + Sbjct: 353 -DRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTH------N 405 Query: 493 YVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNN 552 H PL+F + +DP ER PL+ AS + E L + +H + L Q + N Sbjct: 406 LEDHTKLPLIFHLGRDPGERFPLSFASA-EYQEALSRITSVVQQHQEALVPAQPQLNVCN 464 Query: 553 FLWKPWLQLCCPSTG 567 + W C G Sbjct: 465 WAVMNWAPPGCEKLG 479 Score = 112 bits (279), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 58/141 (41%), Positives = 85/141 (60%), Gaps = 8/141 (5%) Query: 23 AASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAF 82 A PNI+L++ DD+G GD G YG + TPN+DR+A+ G+ +A+PL +PSRAA Sbjct: 1 APQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLXSPSRAAL 60 Query: 83 MTGRYPVRSGMASWSRTGVFLFTASS--GGLPTDEITFAKLLKDQGYSTALIGKWHLGMS 140 +TGR P+R+G + + +T GG+P E +LLK GY + ++GKWHLG Sbjct: 61 LTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLG-- 118 Query: 141 CHSKTDFCHHPLHHGFNYFYG 161 + F HPL HGF+ ++G Sbjct: 119 --HRPQF--HPLKHGFDEWFG 135 >1E2S-P nrPDB Length = 489 Score = 143 bits (361), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 107/325 (32%), Positives = 159/325 (48%), Gaps = 21/325 (6%) Query: 244 MMRNYEIIQQPMSYDNLTQRLTVEAAQFIQ--RNTETPFLLVLSYLHVHTALFSSKDFAG 301 ++ N + QP L R A + + + PF L + H H FS + FA Sbjct: 163 LLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAE 222 Query: 302 KSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSN 361 +S G +GD++ E+D +VG ++ + +L L +TL+ FT+D G +S GG + Sbjct: 223 RSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMS-----RGGCS 277 Query: 362 GIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRII 421 G+ + GK +EGG+R P + WP I G E S++D+ PT+A LAGAPLP + + Sbjct: 278 GLLRCGKGTTYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTL 335 Query: 422 DGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGC 481 DG DL PLL G + +S + LF Y +Y + VR T +KA FFT + Sbjct: 336 DGFDLSPLLLG-TGKSPRQSLFFY-PSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTAD 393 Query: 482 FATHVCFCFGSYVTHHDPPLLFDISKDPRERNPL---TPASEPRFYEILKVMQEAADRHT 538 A H S +T H+PPLL+D+SKDP E L + P + LK +Q + Sbjct: 394 PACHAS----SSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLD 449 Query: 539 QTLPEVPDQFSWNNFLWKPWLQLCC 563 + P Q + P LQ+CC Sbjct: 450 AAVTFGPSQVARGE---DPALQICC 471 Score = 123 bits (308), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 67/140 (47%), Positives = 89/140 (63%), Gaps = 9/140 (6%) Query: 27 PNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGR 86 PNI+L+ ADDLG GD GCYG+ + TPN+D+LA+GG++ T L TPSRAA +TGR Sbjct: 3 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLATPSRAALLTGR 62 Query: 87 YPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTD 146 PVR GM GV L +S GGLP +E+T A++L +GY T + GKWHLG+ + Sbjct: 63 LPVRMGM----YPGV-LVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVG----PE 113 Query: 147 FCHHPLHHGFNYFYGISLTN 166 P H GF+ F GI ++ Sbjct: 114 GAFLPPHQGFHRFLGIPYSH 133 >1FSU-A nrPDB Length = 492 Score = 127 bits (320), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 145/583 (24%), Positives = 231/583 (39%), Gaps = 144/583 (24%) Query: 27 PNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGR 86 P+++ ++ADDLG D G +G++ IRTP++D LA+GGV L + PL TPSR+ +TGR Sbjct: 4 PHLVFLLADDLGWNDVGFHGSR-IRTPHLDALAAGGVLLDNYYT-QPLATPSRSQLLTGR 61 Query: 87 YPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTD 146 Y +R+G+ ++ +P DE +LLK+ GY+T ++GKWHLGM + K Sbjct: 62 YQIRTGLQH-----QIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGM--YRKEC 114 Query: 147 FCHHPLHHGFNYFYG----------------ISLTNLRDCKPG--EGSVFTTGFKRLVFL 188 P GF+ ++G I N+ C +G TG+K + Sbjct: 115 L---PTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNM--- 168 Query: 189 PLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNY 248 + T A+ L H P F L L ++ + Sbjct: 169 ----YSTNIFTKRAI-ALITNHPPEKPLFLYLALQSV----------------------H 201 Query: 249 EIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVY 308 E +Q P Y ++ FIQ K++H Y Sbjct: 202 EPLQVPEEY--------LKPYDFIQ---------------------------DKNRHH-Y 225 Query: 309 GDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGK 368 V MD +VG + L L N+T+ F++D G + GG+N +G K Sbjct: 226 AGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQT--------LAGGNNWPLRGRK 277 Query: 369 ANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMP 428 + WEGG+R G + P + Q G K E D PT+ KLA + +DG D+ Sbjct: 278 WSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWK 337 Query: 429 LLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCF 488 + S E L + ++++ P+NS + K P ++ + + H Sbjct: 338 TISEGSPSPRIELLHNIDPNFVDSSPC-PRNSMAPAKDDSSLPEYSAFNT----SVHAAI 392 Query: 489 CFGSY-----------------------VTHHDPPL----LFDISKDPRERNPLTPASEP 521 G++ + DPP LFDI +DP ER+ L S Sbjct: 393 RHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDL---SRE 449 Query: 522 RFYEILKVMQEAADRHTQTLP-----EVPDQFSWNNFLWKPWL 559 + + K++ H ++P + P +W PW+ Sbjct: 450 YPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM 492 >6BIA-A nrPDB Length = 477 Score = 114 bits (284), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 65/144 (45%), Positives = 80/144 (55%), Gaps = 13/144 (9%) Query: 21 SHAAS--RPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPS 78 SH AS +PNIIL++ADDLG D G G+K I TPNID LA G + A P C PS Sbjct: 19 SHMASEQKPNIILIVADDLGYADVGFNGSKDIITPNIDDLAKSGTSFSDAYVAHPFCGPS 78 Query: 79 RAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLG 138 RAA MTGRYP + G T S+ G+PTD +KLL + Y T +GKWH+G Sbjct: 79 RAALMTGRYPHKIGSQFNLPT-----RGSNVGVPTDAKFISKLLNENNYFTGALGKWHMG 133 Query: 139 MSCHSKTDFCHHPLHHGFNYFYGI 162 + HHP GF+ +YG Sbjct: 134 DTPQ------HHPNKRGFDEYYGF 151 Score = 95.5 bits (236), Expect = 6e-20, Method: Compositional matrix adjust. Identities = 58/177 (32%), Positives = 91/177 (51%), Gaps = 16/177 (9%) Query: 260 LTQRLTVEAAQFIQR--NTETPFLLVLSYLHVHTALFSS-KDFA-----GKSQHGVYGDA 311 +T L+ EA F+ + N + PF L L+Y HT L + +D A Y Sbjct: 198 ITDALSREAVNFVDKAVNKKHPFFLYLAYNAPHTPLQAKDEDMAMFPNIKNKDRKTYAGM 257 Query: 312 VEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANN 371 V +D VG+++ L + ++TLI F SD G + + G +N K GK + Sbjct: 258 VYAVDRGVGKLVEALKKNNQYDNTLIVFMSDNGGKLSK--------GANNFPLKAGKGST 309 Query: 372 WEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMP 428 EGG RVP + WP+ + AG++ P S +D++PT A LAGA + E++ +DG ++ P Sbjct: 310 QEGGFRVPMLFHWPKHVPAGKRFSHPVSALDLYPTFAALAGAKVEENQHLDGTNMWP 366 >4CXU-A nrPDB Length = 536 Score = 99.8 bits (247), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 131/565 (23%), Positives = 222/565 (39%), Gaps = 111/565 (19%) Query: 24 ASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFM 83 + RPN ++++ADDLG D G +G + I TPN+D LA G++LT AS +P+R+ + Sbjct: 2 SKRPNFLVIVADDLGFSDIGTFGGE-IATPNLDALAIAGLRLTDFHTAS-AASPTRSMLL 59 Query: 84 TGRYPVRSGMASWSRTGVFLFTASSGGLPTDE-------ITFAKLLKDQGYSTALIGKWH 136 TG +G+ + + T G P E + +LL++ GY T + GKWH Sbjct: 60 TGTDHHIAGIGTMAEA----LTPELEGKPGYEGHLNERVVALPELLREAGYQTLMAGKWH 115 Query: 137 LGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVT 196 LG+ P GF + + PG + + P + G Sbjct: 116 LGLKPEQT------PHARGFERSFAL--------LPGAANHYGFEPPYDESTPRILKGTP 161 Query: 197 LLTLAALNCLGLLHVPLGVFFSLLFLAALILTL--------FLGFLHYFRPLNCFMMRNY 248 L + L L P G + S F L+ L F +L + P + + Sbjct: 162 ALYVEDERYLDTL--PEGFYSSDAFGDKLLQYLKERDQSRPFFAYLPFSAP-HWPLQAPR 218 Query: 249 EIIQQPMS-YDNLTQRLTVEAAQFIQR----NTETPFLLVLSYLHVHTALFSSKDFAGKS 303 EI+++ YD + L E ++ + VL+ AL + Sbjct: 219 EIVEKYRGRYDAGPEALRQERLARLKELGLVEADVEAHPVLALTREWEALEDEERAKSAR 278 Query: 304 QHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAH---VEEVSSKG------ 354 VY VE MDW++G++++ L ++T + F SD GA +E G Sbjct: 279 AMEVYAAMVERMDWNIGRVVDYLRRQGELDNTFVLFMSDNGAEGALLEAFPKFGPDLLDF 338 Query: 355 -EIHGGSNGIYKGGKANNW-----------------------EGGIRVPGILRWPRVIQA 390 + H N + G+AN++ +GGIRVP ++R+PR+ + Sbjct: 339 LDRH-YDNSLENIGRANSYVWYGPRWAQAATAPSRLYKAFTTQGGIRVPALVRYPRLSRQ 397 Query: 391 GQKIDEPTSNMDIFPTVAKLAGAPLPEDR-----IID--GRDLMPLLEGKSQRSDHEFLF 443 G + MD+ PT+ LAG P R I + GR + L G+++ + Sbjct: 398 GAISHAFATVMDVTPTLLDLAGVRHPGKRWRGREIAEPRGRSWLGWLSGETEAA------ 451 Query: 444 HYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLF 503 H +N+ + W F + A ++ G L+ Sbjct: 452 ------------HDENTVTGWGLF----GMRAIRQGDWKAVYLPAPVGPATWQ-----LY 490 Query: 504 DISKDPRERNPLTPASEPRFYEILK 528 D+++DP E + L + + E+++ Sbjct: 491 DLARDPGEIHDLADSQPGKLAELIE 515 >5G2V-A nrPDB Length = 534 Score = 92.8 bits (229), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 47/122 (38%), Positives = 66/122 (54%), Gaps = 11/122 (9%) Query: 16 LWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLC 75 L + + RPNII +M DD CYG I+TPN+DR+A+ G++ A + L Sbjct: 18 LRQPQKEETKRPNIIFMMTDDHTTQAMSCYGGNLIQTPNMDRIANEGIRFDNCYAVNALS 77 Query: 76 TPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKW 135 PSRA +TG++ +G FT ++ D+ TF KLL+ GY TA+IGKW Sbjct: 78 GPSRACILTGKFSHENG-----------FTDNASTFNGDQQTFPKLLQQAGYQTAMIGKW 126 Query: 136 HL 137 HL Sbjct: 127 HL 128 Score = 61.6 bits (148), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 58/235 (24%), Positives = 109/235 (46%), Gaps = 45/235 (19%) Query: 315 MDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEG 374 +D ++G++LN L+++ ++T+I +TSDQG + G +G + K +E Sbjct: 322 VDENIGRLLNYLEKIGELDNTIIVYTSDQGFFL-----------GEHGWF--DKRFMYEE 368 Query: 375 GIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLL--EG 432 R+P I+R+P+ I+AG + N+D PT AG +P D I G L P+L EG Sbjct: 369 CQRMPLIIRYPKAIKAGSTSSAISMNVDFAPTFLDFAGVEVPSD--IQGASLKPVLENEG 426 Query: 433 KSQRSDHEFLFHYCNAY--LNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCF 490 K+ + +++ Y ++V+ H T +K F +N + Sbjct: 427 KTPADWRKAAYYHYYEYPAEHSVKRHYGIRTQDFKLIHF---YNDI-------------- 469 Query: 491 GSYVTHHDPPLLFDISKDPRERNPLTPASE--PRFYEILKVMQEAADRHTQTLPE 543 D ++D+ DPRE N + +E + E++++++E ++ P+ Sbjct: 470 -------DEWEMYDMKADPREMNNIFGKAEYAKKQKELMQLLEETQKQYKDNDPD 517 >6IOZ-A nrPDB Length = 517 Score = 92.0 bits (227), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 106/421 (25%), Positives = 176/421 (41%), Gaps = 71/421 (16%) Query: 28 NIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRY 87 N++L++ DDL GCYG+K +R+PNID+LAS + A + PSR +F+TGR Sbjct: 5 NVLLIIVDDLRPSL-GCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVAAPSRVSFLTGRR 63 Query: 88 PVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGK-WHLGMSCHSKTD 146 P + + ++ + +G T + K+ GY T +GK +H G+S + D Sbjct: 64 PDTTRLYDFNS----YWRVHAGNF----STIPQYFKENGYVTMSVGKVFHPGISSNHTDD 115 Query: 147 FCHH---PLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTL--- 200 + P +H + Y N + C+ +G + + P+ ++ V TL Sbjct: 116 SPYSWSFPPYHPSSEKY----ENTKTCRGPDGELHAN-----LLCPVDVLDVPEGTLPDK 166 Query: 201 -AALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDN 259 + + LL + S FLA + F + + + N + P D Sbjct: 167 QSTEQAIQLLEK-MKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDG 225 Query: 260 LTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSV 319 L QR + + Y + DF K + + +V +D V Sbjct: 226 LPPVAYNPWMDIRQREDVQALNISVPYGPIPV------DFQRKIRQSYFA-SVSYLDTQV 278 Query: 320 GQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVP 379 G++L+ LD+L+LAN T+I FTSD G + E HG + K +N++ VP Sbjct: 279 GRLLSALDDLQLANSTIIAFTSDHGWALGE-------HG------EWAKYSNFDVATHVP 325 Query: 380 GILRWP----RVIQAGQKI-------DEPTSNMD-------------IFPTVAKLAGAPL 415 I P + +AG+K+ D + M+ +FPT+A LAG + Sbjct: 326 LIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQV 385 Query: 416 P 416 P Sbjct: 386 P 386 >2QZU-A nrPDB Length = 491 Score = 82.0 bits (201), Expect = 6e-16, Method: Compositional matrix adjust. Identities = 43/145 (29%), Positives = 72/145 (49%), Gaps = 15/145 (10%) Query: 27 PNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGR 86 PN++ +MAD GC G + ++TP++D+LAS G+ T +++ P+ +P+R MTG Sbjct: 28 PNLVFIMADQYRGDAIGCIGKEPVKTPHLDKLASEGINFTNAISSYPVSSPARGMLMTGM 87 Query: 87 YPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTD 146 YP+ S + + + L + ++ +LKDQGY+ IGKWHL D Sbjct: 88 YPIGSKVTGNCNSETAPYGVE---LSQNARCWSDVLKDQGYNMGYIGKWHLDAPYKPYVD 144 Query: 147 ------------FCHHPLHHGFNYF 159 +C HGF+++ Sbjct: 145 TYNNRGKVAWNEWCPPERRHGFDHW 169 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 34/132 (25%), Positives = 61/132 (46%), Gaps = 16/132 (12%) Query: 308 YGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYK-G 366 Y + +D +VG+I+ L + L ++T++ FTSD HG G ++ Sbjct: 279 YYACITGVDENVGRIIEALKQNNLFDNTIVVFTSD--------------HGICMGAHENA 324 Query: 367 GKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDL 426 GK +E +R+P IL WP I+ + + D++PT+ + G + DL Sbjct: 325 GKDIFYEESMRIPMILSWPDQIKPRKSDPLMIAFADLYPTLLSMMGFSKEIPETVQTFDL 384 Query: 427 M-PLLEGKSQRS 437 +L GK+++ Sbjct: 385 SNEVLTGKNKKD 396 >4UPL-A nrPDB Length = 569 Score = 68.9 bits (167), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 43/112 (38%), Positives = 59/112 (52%), Gaps = 15/112 (13%) Query: 28 NIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRY 87 NI+ +M D L CYG+KT+ TP+IDRLA+ GV+ + SP+C SR + TGRY Sbjct: 19 NILFIMFDQLRWDYLSCYGHKTLNTPHIDRLAAKGVRFDRAYIQSPICGSSRMSTYTGRY 78 Query: 88 PVRSGMASWSRTGVFLFTASSGGLP--TDEITFAKLLKDQGYSTALIGKWHL 137 V S ASW+ G+P E+T L+ G L+GK H+ Sbjct: 79 -VHSHGASWN------------GIPLKVGEMTMGDHLRAAGMGCWLVGKTHM 117 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 53/210 (25%), Positives = 81/210 (38%), Gaps = 36/210 (17%) Query: 307 VYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKG 366 Y +++ D +G++ L++ DT+I TSD G + + + G Sbjct: 308 AYMGLIKQADDQMGRLFKWLEDTGRMQDTMIVLTSDHGDFLGDH-------------WMG 354 Query: 367 GKANNWEGGIRVPGILRWPR---VIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDG 423 K + RVP I+ PR G D ++D+ PT + AG P I++G Sbjct: 355 EKTFFHDASTRVPLIIYDPRPEADATRGSVCDALVESIDLAPTFVEAAGGK-PAMHILEG 413 Query: 424 RDLMPLLEGKSQRSDHEFLFHY-CNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCF 482 L+P+L G DH H C +A N S+ +A F V Sbjct: 414 ESLIPILHGA---RDHTLRDHVICEYDFSASPIAHLNDISVRQAVMFM-----VADKNWK 465 Query: 483 ATHVCFCFGSYVTHHDP-PLLFDISKDPRE 511 H DP P+LFD+ DP+E Sbjct: 466 LIHF---------EADPRPMLFDLKNDPQE 486 >2W8S-A nrPDB Length = 543 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 123/515 (23%), Positives = 192/515 (37%), Gaps = 89/515 (17%) Query: 50 IRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSG 109 ++TPN+DRL G+ H+ P+RA+ +TG Y + A Sbjct: 61 LKTPNLDRLCREGLTFRNHVTTCVPGGPARASLLTGLY-------------LMNHRAVQN 107 Query: 110 GLPTDE--ITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNL 167 +P D+ + K L+ GY ALI G + + F G + Sbjct: 108 TVPLDQRHLNLGKALRAIGYDPALI-----GYTTTTPDPRTTSARDPRFTVL-GDIMDGF 161 Query: 168 RDCKPGE-------GSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGV---FF 217 R E G V GF+ LP + L + G P + F Sbjct: 162 RSVGAFEPNMEGYFGWVAQNGFE----LPENREDI-WLPEGEHSVPGATDKPSRIPKEFS 216 Query: 218 SLLFLAALILTLFLG------FLH--YFRPLNCFM-------MRNYEIIQQPMSYDNLTQ 262 F LT G FLH Y+RP F+ M E + P+ +N Sbjct: 217 DSTFFTERALTYLKGRDGKPFFLHLGYYRPHPPFVASAPYHAMYKAEDMPAPIRAENPD- 275 Query: 263 RLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQ-HGVYGDAVEEMDWSVGQ 321 EAAQ + S+ H ++ D Q Y + E+D +G+ Sbjct: 276 ---AEAAQHPLMKHYIDHIRRGSFFHGAEGSGATLDEGEIRQMRATYCGLITEIDDCLGR 332 Query: 322 ILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGI 381 + LDE +DTLI FTSD G + + G+I G A ++ R+P + Sbjct: 333 VFAYLDETGQWDDTLIIFTSDHGEQLGDHHLLGKI---------GYNAESF----RIPLV 379 Query: 382 LR-WPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLL-EGKSQRSDH 439 ++ + AGQ + + ++D+ PT+ + G P R DGR L+P L EGK SD Sbjct: 380 IKDAGQNRHAGQIEEGFSESIDVMPTILEWLGGETP--RACDGRSLLPFLAEGKP--SDW 435 Query: 440 EFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDP 499 HY + + PQNS + + + C + + + P Sbjct: 436 RTELHYEFDFRDVFYDQPQNSVQLSQD----------DCSLCVIEDENYKYVHFAAL--P 483 Query: 500 PLLFDISKDPRERNPLTPASEPRFYEILKVMQEAA 534 PL FD+ DP E + L A +P + +++ + A Sbjct: 484 PLFFDLKADPHEFSNL--AGDPAYAALVRDYAQKA 516 >2VQR-A nrPDB Length = 543 Score = 65.1 bits (157), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 123/520 (23%), Positives = 192/520 (36%), Gaps = 99/520 (19%) Query: 50 IRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSG 109 ++TPN+DRL GV H+ P+RA+ +TG Y + A Sbjct: 61 LKTPNLDRLCREGVTFRNHVTTCVPAGPARASLLTGLY-------------LMNHRAVQN 107 Query: 110 GLPTDE--ITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHP-------LHHGFN--- 157 +P D+ + K L+ GY ALIG + +T + P L GF+ Sbjct: 108 TVPLDQRHLNLGKALRGVGYDPALIG--YTTTVPDPRTTSPNDPRFRVLGDLMDGFHPVG 165 Query: 158 --------YFYGISLT--NLRDCKP------GEGSVFTTGFKRLVFLPLQIVGVTLLTLA 201 YF ++ +L + +P GE +V R +P + T T Sbjct: 166 AFEPNMEGYFGWVAQNGFDLPEHRPDIWLPEGEDAV-AGATDRPSRIPKEFSDSTFFTER 224 Query: 202 ALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRN-YEIIQQP--MSYD 258 AL +L F L Y+RP F+ Y + +P M Sbjct: 225 ALT----------------YLKGRDGKPFFLHLGYYRPHPPFVASAPYHAMYRPEDMPAP 268 Query: 259 NLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQ-HGVYGDAVEEMDW 317 +EAAQ + S+ ++ D A Q Y + E+D Sbjct: 269 IRAANPDIEAAQHPLMKFYVDSIRRGSFFQGAEGSGATLDEAELRQMRATYCGLITEVDD 328 Query: 318 SVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIR 377 +G++ + LDE +DTLI FTSD G + + G+I G N + R Sbjct: 329 CLGRVFSYLDETGQWDDTLIIFTSDHGEQLGDHHLLGKI--GYN-----------DPSFR 375 Query: 378 VPGILR-WPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLL-EGKSQ 435 +P +++ +AG T ++D+ PT+ G +P DG L+P L EG+ Q Sbjct: 376 IPLVIKDAGENARAGAIESGFTESIDVMPTILDWLGGKIPH--ACDGLSLLPFLSEGRPQ 433 Query: 436 RSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVT 495 D HY + + PQ +F +G N C + YV Sbjct: 434 --DWRTELHYEYDFRDVYYSEPQ-------------SFLGLGMNDCSLCVIQDERYKYVH 478 Query: 496 HHD-PPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAA 534 PPL FD+ DP E L A +P + +++ + A Sbjct: 479 FAALPPLFFDLRHDPNEFTNL--ADDPAYAALVRDYAQKA 516 >4UPI-A nrPDB Length = 576 Score = 62.8 bits (151), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 40/112 (35%), Positives = 55/112 (49%), Gaps = 15/112 (13%) Query: 28 NIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRY 87 NI+ +M D L CYG++ + TPNID+LA GV+ T + + PSR + TGRY Sbjct: 30 NILWIMCDQLRFDYLSCYGHERLNTPNIDKLAKRGVRFTNAYVQATVAGPSRMSAYTGRY 89 Query: 88 PVRSGMASWSRTGVFLFTASSGGLP--TDEITFAKLLKDQGYSTALIGKWHL 137 VRS ++ G+P E T L+D G LIGK H+ Sbjct: 90 -VRS------------HGSTQNGIPLRVGEPTLGDHLRDVGMRNVLIGKTHM 128 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 34/135 (25%), Positives = 61/135 (45%), Gaps = 17/135 (12%) Query: 312 VEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANN 371 ++++D +GQ+ + E L +T+I FT+D G ++ + + G K Sbjct: 322 IKQIDDQLGQLFAFMQERGLDENTMIVFTADHGDYLGD-------------HWMGEKYLF 368 Query: 372 WEGGIRVPGILRWPR---VIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMP 428 +E +VP I+ P G D +D+ PT AG +P I++G+ L+P Sbjct: 369 YEAAAKVPLIIYDPSDKADATRGTVSDALVEMIDLAPTFVDYAGG-VPPMHILEGKSLLP 427 Query: 429 LLEGKSQRSDHEFLF 443 LL D +++F Sbjct: 428 LLHDDDSSWDRQYVF 442 >4UPK-A nrPDB Length = 538 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 100/483 (20%), Positives = 172/483 (35%), Gaps = 67/483 (13%) Query: 50 IRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSG 109 + P++ LA V +H + + C PSRA+ +TG+Y + R G Sbjct: 57 VELPHLRALAQDAVSFRRHYSVTNPCGPSRASILTGQYAMNHRSV---RNGT-------- 105 Query: 110 GLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNY----FYGISLT 165 L D A ++ GY L G + S + + P + + F+ ++ Sbjct: 106 PLRHDTPNIATEMRKAGYLPLLFG--YTDTSQDPRAYDANDPALKTYEFPMRGFHEVTEM 163 Query: 166 NLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLG--VFFSLLFLA 223 L P + + G+ + + + LN + F + FLA Sbjct: 164 RLEMSYPWQSHLKNRGYAFDDYAQVYVPRPDADGTPRLNGPAMYRAEDSDTAFLTDQFLA 223 Query: 224 ---ALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVE-AAQFIQRNTET- 278 A + L Y RP + + P Y+ + + A+ R+ ET Sbjct: 224 NMPAWAGQNWFAHLTYIRP--------HPPLVAPAPYNTMYDPAKLPLPARLPGRDDETA 275 Query: 279 --PFLLVLSYLHVHTAL------FSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELR 330 PF + + D ++ VY E+D +G+++ L E Sbjct: 276 EHPFFGPATRYSSPASFVLGFPDLEPTDETIQTLRAVYLGLATEVDTHIGRVIAHLKETG 335 Query: 331 LANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQA 390 +DTLI T+D G + G+ H GK ++ P I+R P + Sbjct: 336 QYDDTLIVVTADHGEML------GDRH-------SWGKMTVYDAAYHTPLIIRAPGC-KP 381 Query: 391 GQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYL 450 G ++ PT ++D+ PT+ G +P +DGR L P L G++ ++ F + Sbjct: 382 GHVVEAPTESIDLMPTILDWVGQEIPN--AVDGRSLRPFLTGEAPSDWRQYSFSELDIS- 438 Query: 451 NAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPR 510 P + T +W+ F F P F + PP+LFD + Sbjct: 439 -----EPLDPT-LWQQEF---GFGPSAGAVAILRDARFTLVEFAADL-PPMLFDHQGEGE 488 Query: 511 ERN 513 RN Sbjct: 489 FRN 491 >4UG4-A nrPDB Length = 515 Score = 58.9 bits (141), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 44/119 (36%), Positives = 64/119 (53%), Gaps = 16/119 (13%) Query: 315 MDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEG 374 +D VG++++ L R+ +DTLI F SD G + G G++ K N +EG Sbjct: 272 LDEKVGELIDTLTRTRMLDDTLILFCSDHGDML-----------GERGLW--FKMNFFEG 318 Query: 375 GIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDR-IIDGRDLMPLLEG 432 RVP ++ P I G + PTSN+D+ PT+A LAG L E R DG L+P++ G Sbjct: 319 SARVPLMIAGPG-IAPGLHL-TPTSNLDVTPTLADLAGISLEEVRPWTDGVSLVPMVNG 375 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 39/117 (33%), Positives = 56/117 (47%), Gaps = 21/117 (17%) Query: 26 RPNIILVMADDLG----IGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAA 81 +PNI+++M D L P + + PN+ LA + + +SPLC P+RA+ Sbjct: 8 KPNILIIMVDQLNGKLFPDGPADF----LHAPNLKALAKRSARFHNNYTSSPLCAPARAS 63 Query: 82 FMTGRYPVRSGMASWSRTGVFLFTAS-SGGLPTDEITFAKLLKDQGYSTALIGKWHL 137 FM G+ P SRT V+ A +P T+A L+ GY TAL GK H Sbjct: 64 FMAGQLP--------SRTRVYDNAAEYQSSIP----TYAHHLRRAGYYTALSGKMHF 108 >4UPH-A nrPDB Length = 547 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 57/207 (27%), Positives = 88/207 (42%), Gaps = 31/207 (14%) Query: 307 VYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKG 366 +Y + E+D +G+I L + +DTLI FTSD H E + + Sbjct: 322 IYYGMIAEVDTQLGRIWQALKNVGAWDDTLIIFTSD---HAEMMGDH----------WML 368 Query: 367 GKANNWEGGIRVPGILRWP-RVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRD 425 GK ++G VP ++R P AG++++ TS DIFPT+ G L D +DG Sbjct: 369 GKGGFFDGSYHVPLVIRDPGHPGGAGRQVERFTSAADIFPTLCDRLG--LVPDNHLDGGT 426 Query: 426 LMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATH 485 L+P LEG + F + + + + + + SN C Sbjct: 427 LVPFLEGGEPEGWRDAAFWEFD-FRDIAKGEAERHFGL-------------KSNACNLAV 472 Query: 486 VCFCFGSYVTHHD-PPLLFDISKDPRE 511 + YV PPLL+D++KDP E Sbjct: 473 IRDERFKYVHFAGLPPLLYDLAKDPME 499 Score = 52.0 bits (123), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 24/65 (36%), Positives = 37/65 (56%) Query: 23 AASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAF 82 + RPN++L+ AD G+ +++TPN+D LA GV T+H A + +P+RA Sbjct: 41 SGKRPNVLLISADQWRGDCLSAVGHASVKTPNVDALAQDGVLFTRHFAGTAPASPARATL 100 Query: 83 MTGRY 87 TG Y Sbjct: 101 YTGLY 105 >5G2T-A nrPDB Length = 489 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 35/112 (31%), Positives = 48/112 (42%), Gaps = 6/112 (5%) Query: 25 SRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMT 84 +PN +++ D L G YG T ID +AS GV + PL PSRAA + Sbjct: 22 EKPNFLIIQCDHLTQRVVGAYGQTQGCTLPIDEVASRGVIFSNAYVGCPLSQPSRAALWS 81 Query: 85 GRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWH 136 G P ++ + S S V + LP + T L + GY GK H Sbjct: 82 GMMPHQTNVRSNSSEPV------NTRLPENVPTLGSLFSESGYEAVHFGKTH 127 Score = 42.0 bits (97), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 42/154 (27%), Positives = 65/154 (42%), Gaps = 34/154 (22%) Query: 378 VPGILRWPRVIQAGQKID----EPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGK 433 VP I P + Q + +D +PT +D+ PT+ LAG +P ++ G L P L G+ Sbjct: 315 VPFIFAGPGIKQQKKPVDHLLTQPT--LDLLPTLCDLAGIAVPAEKA--GISLAPTLRGE 370 Query: 434 SQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSY 493 Q+ H ++ WH + + TP G + TH G Sbjct: 371 KQKKSHPYV---------VSEWHSEYE------YVTTPGRMVRGPRYKY-THYLEGNGEE 414 Query: 494 VTHHDPPLLFDISKDPRERNPLTPASEPRFYEIL 527 L+D+ KDP ER L A +P++ +IL Sbjct: 415 --------LYDMKKDPGERKNL--AKDPKYSKIL 438 >4MHX-A nrPDB Length = 510 Score = 47.0 bits (110), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 62/269 (23%), Positives = 106/269 (39%), Gaps = 43/269 (15%) Query: 287 LHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAH 346 L V F A ++ V MD VG +L L + + NDTL+ FTSD Sbjct: 218 LDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSD---- 273 Query: 347 VEEVSSKGEIHGGSNGI-YKGGKANNWEGGIRVPGILRWPRVIQA-GQKIDEPTSNMDIF 404 NGI + G+ N + G P ++ P + GQ + S +D+ Sbjct: 274 --------------NGIPFPSGRTNLYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLT 319 Query: 405 PTVAKLAGAPLPEDRI-------IDGRDLMPLLEGK-------SQRSDHEFLFHYCNAYL 450 PT+ P P I + GR L+P LE + +S HE Y + Sbjct: 320 PTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWATVFGSQSHHEVTMSYPMRSV 379 Query: 451 NAVRWHPQNSTS------IWKAFFFTPNFNPVGSNGCFATHVCFCFG-SYVTHHDPPLLF 503 + ++ + I + F+ +P F + + + + + L+ Sbjct: 380 QHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTAGQPTGWYKDLRHYYYRARWELY 439 Query: 504 DISKDPRERNPLTPASEPRFYEILKVMQE 532 D S+DP E L A++PRF ++L+++++ Sbjct: 440 DRSRDPHETQNL--ATDPRFAQLLEMLRD 466 Score = 37.4 bits (85), Expect = 0.018, Method: Compositional matrix adjust. Identities = 39/127 (30%), Positives = 61/127 (48%), Gaps = 10/127 (7%) Query: 25 SRP-NIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFM 83 +RP N +L++ADD G + G Y N I TP++D LA + + +PSRA+ + Sbjct: 20 ARPRNALLLLADDGGF-ESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSSSPSRASLL 78 Query: 84 TGRYPVRSGMASWSRTGVFLFTASSGGLPTDEI-TFAKLLKDQGYSTALIGKWHLGMSCH 142 TG ++GM + V F + D++ + LL G T +IGK H+G Sbjct: 79 TGLPQHQNGMYGLHQ-DVHHFNS------FDKVRSLPLLLSQAGVRTGIIGKKHVGPETV 131 Query: 143 SKTDFCH 149 DF + Sbjct: 132 YPFDFAY 138 >3LXQ-A nrPDB Length = 450 Score = 41.6 bits (96), Expect = 0.001, Method: Compositional matrix adjust. Identities = 35/112 (31%), Positives = 49/112 (43%), Gaps = 12/112 (10%) Query: 21 SHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRA 80 ++ R N+++++ + LG G G + TPN+D L G + TQ A Sbjct: 80 TYQGKRKNLVILLQESLGAQFVGSLGGLPL-TPNLDELMQEGWQFTQMYATGTRSVRGIE 138 Query: 81 AFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALI 132 A TG P S SR V L + +G T A LLK+QGY T I Sbjct: 139 AVTTGFPP------SPSRAVVKLSKSQTGFF-----TIADLLKEQGYHTQFI 179 >5XWI-A nrPDB Length = 567 Score = 32.0 bits (71), Expect = 0.80, Method: Compositional matrix adjust. Identities = 24/64 (37%), Positives = 37/64 (57%), Gaps = 8/64 (12%) Query: 372 WEGGIRVPGILRWPRVIQAGQKIDEP--TSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPL 429 W+ RVP IL W + +Q ++P +DI P++A L P+P+D+ IDGR + L Sbjct: 495 WDTDRRVP-ILFWRKGMQ---HFEQPLGVETVDILPSLAALIKLPVPKDQ-IDGR-CLDL 548 Query: 430 LEGK 433 + GK Sbjct: 549 VAGK 552 >2ZQB-A nrPDB Length = 158 Score = 30.8 bits (68), Expect = 1.6, Method: Compositional matrix adjust. Identities = 28/132 (21%), Positives = 49/132 (37%), Gaps = 10/132 (7%) Query: 29 IILVMADDLGIGDPGCYGNKTI-RTPNIDRLASGGVKLTQH---------LAASPLCTPS 78 +I + D +G+PG G + + + SGG LT + +A L P Sbjct: 6 LIHIFTDGSCLGNPGPGGYGIVMKYKGHTKEMSGGFSLTTNNRMELLAPIVALEALKEPC 65 Query: 79 RAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLG 138 + + VR G+ +W +S G P + K L + +W G Sbjct: 66 KIILTSDSQYVRQGIMTWIHGWKKNGWMTSNGTPVKNVDLWKRLDKAAQLHQIDWRWVKG 125 Query: 139 MSCHSKTDFCHH 150 + H++ + CH Sbjct: 126 HAGHAENERCHQ 137 >4JCQ-A nrPDB Length = 201 Score = 28.9 bits (63), Expect = 5.9, Method: Compositional matrix adjust. Identities = 15/42 (35%), Positives = 25/42 (59%), Gaps = 2/42 (4%) Query: 307 VYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVE 348 +YG+ +E+ V + L LL+ + +ND + F + QG HVE Sbjct: 26 IYGEINQELAEDVSKQLLLLESI--SNDPITIFINSQGGHVE 65 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1P49-A nrPDB 781 0.0 4FDJ-A nrPDB 403 e-113 1E2S-P nrPDB 361 e-100 1FSU-A nrPDB 360 1e-99 2VQR-A nrPDB 349 2e-96 2W8S-A nrPDB 346 1e-95 3ED4-A nrPDB 343 2e-94 4CXU-A nrPDB 339 1e-93 4UPK-A nrPDB 339 2e-93 5G2V-A nrPDB 315 4e-86 4UPH-A nrPDB 297 1e-80 6BIA-A nrPDB 289 3e-78 4UPL-A nrPDB 286 2e-77 6IOZ-A nrPDB 279 2e-75 4UPI-A nrPDB 279 2e-75 2QZU-A nrPDB 277 1e-74 4MHX-A nrPDB 228 6e-60 5G2T-A nrPDB 220 9e-58 4UG4-A nrPDB 212 3e-55 3LXQ-A nrPDB 133 2e-31 Sequences not found previously or not previously below threshold: 4UOP-A nrPDB 79 5e-15 5I5H-A nrPDB 75 8e-14 5I5F-A nrPDB 72 6e-13 2W8D-A nrPDB 56 3e-08 4UOO-A nrPDB 55 1e-07 2W5S-A nrPDB 53 4e-07 1O99-A nrPDB 51 2e-06 5XWI-A nrPDB 50 2e-06 4LR8-A nrPDB 45 7e-05 4QAX-A nrPDB 43 3e-04 5UDY-A nrPDB 43 4e-04 3E2D-A nrPDB 43 5e-04 5VPU-A nrPDB 42 5e-04 2W5W-A nrPDB 40 0.002 4LR2-A nrPDB 40 0.003 5VEN-A nrPDB 38 0.011 4AGS-A nrPDB 37 0.022 5MX9-A nrPDB 37 0.024 5YLE-A nrPDB 37 0.027 5VEM-A nrPDB 35 0.12 4B56-A nrPDB 34 0.17 6G4G-A nrPDB 34 0.23 5EGE-A nrPDB 33 0.35 5JTL-E nrPDB 33 0.50 5X3I-A nrPDB 32 0.78 3WKX-A nrPDB 31 1.0 5OLB-A nrPDB 31 2.0 5MHP-A nrPDB 30 2.5 4OKD-A nrPDB 30 3.4 5XGU-B nrPDB 30 3.4 6C01-A nrPDB 30 3.7 3OH0-A nrPDB 29 5.3 4IWS-A nrPDB 29 6.6 >1P49-A nrPDB Length = 562 Score = 781 bits (2017), Expect = 0.0, Method: Composition-based stats. Identities = 561/562 (99%), Positives = 561/562 (99%) Query: 22 HAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAA 81 HAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPL TPSRAA Sbjct: 1 HAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLATPSRAA 60 Query: 82 FMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSC 141 FMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSC Sbjct: 61 FMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSC 120 Query: 142 HSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLA 201 HSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLA Sbjct: 121 HSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLA 180 Query: 202 ALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLT 261 ALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLT Sbjct: 181 ALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLT 240 Query: 262 QRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQ 321 QRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQ Sbjct: 241 QRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQ 300 Query: 322 ILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGI 381 ILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGI Sbjct: 301 ILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGI 360 Query: 382 LRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEF 441 LRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEF Sbjct: 361 LRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEF 420 Query: 442 LFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPL 501 LFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPL Sbjct: 421 LFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPL 480 Query: 502 LFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQL 561 LFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQL Sbjct: 481 LFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQL 540 Query: 562 CCPSTGLSCQCDREKQDKRLSR 583 CCPSTGLSCQCDREKQDKRLSR Sbjct: 541 CCPSTGLSCQCDREKQDKRLSR 562 >4FDJ-A nrPDB Length = 502 Score = 403 bits (1036), Expect = e-113, Method: Composition-based stats. Identities = 166/552 (30%), Positives = 238/552 (43%), Gaps = 80/552 (14%) Query: 23 AASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAF 82 A PNI+L++ DD+G GD G YG + TPN+DR+A+ G+ +A+PL +PSRAA Sbjct: 1 APQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLXSPSRAAL 60 Query: 83 MTGRYPVRSGMASWSRTGVFLFTASS--GGLPTDEITFAKLLKDQGYSTALIGKWHLGMS 140 +TGR P+R+G + + +T GG+P E +LLK GY + ++GKWHLG Sbjct: 61 LTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLG-- 118 Query: 141 CHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTL 200 H P H + + G F P Sbjct: 119 --------HRPQFHPLKH-------------GFDEW---FGSPNCHFGP----------- 143 Query: 201 AALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNL 260 P + + F L NL Sbjct: 144 -----YDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEA-------------------NL 179 Query: 261 TQRLTVEAAQFIQRNTET-PFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSV 319 TQ EA FI+R PF L + H +++SK F G SQ G YGDAV E+D S+ Sbjct: 180 TQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSI 239 Query: 320 GQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVP 379 G+IL LL +L +A++T ++FTSD GA + + GGSNG + GK +EGG+R P Sbjct: 240 GKILELLQDLHVADNTFVFFTSDNGAALISAPEQ----GGSNGPFLCGKQTTFEGGMREP 295 Query: 380 GILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDH 439 + WP + AGQ + S MD+F T LAG P DR IDG +L+P L D Sbjct: 296 ALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLM-DR 354 Query: 440 EFLFHYCNAYLNAV----RWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVT 495 ++ + + A + H T+ W+ F +F P + TH + Sbjct: 355 PIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTH------NLED 408 Query: 496 HHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLW 555 H PL+F + +DP ER PL+ AS + E L + +H + L Q + N+ Sbjct: 409 HTKLPLIFHLGRDPGERFPLSFASA-EYQEALSRITSVVQQHQEALVPAQPQLNVCNWAV 467 Query: 556 KPWLQLCCPSTG 567 W C G Sbjct: 468 MNWAPPGCEKLG 479 >1E2S-P nrPDB Length = 489 Score = 361 bits (927), Expect = e-100, Method: Composition-based stats. Identities = 175/544 (32%), Positives = 248/544 (45%), Gaps = 78/544 (14%) Query: 25 SRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMT 84 PNI+L+ ADDLG GD GCYG+ + TPN+D+LA+GG++ T L TPSRAA +T Sbjct: 1 RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLATPSRAALLT 60 Query: 85 GRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSK 144 GR PVR GM L +S GGLP +E+T A++L +GY T + GKWHLG+ Sbjct: 61 GRLPVRMGMY-----PGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPE-- 113 Query: 145 TDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALN 204 P H GF R + +P L Sbjct: 114 --GAFLPPHQ--------------------------GFHRFLGIP---YSHDQGPCQNLT 142 Query: 205 CLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRL 264 C G L + ++ N + QP L R Sbjct: 143 CFPPATPCDGGCDQGL-------------------VPIPLLANLSVEAQPPWLPGLEARY 183 Query: 265 TVEAAQFIQ--RNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQI 322 A + + + PF L + H H FS + FA +S G +GD++ E+D +VG + Sbjct: 184 MAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTL 243 Query: 323 LNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGIL 382 + + +L L +TL+ FT+D G +S GG +G+ + GK +EGG+R P + Sbjct: 244 MTAIGDLGLLEETLVIFTADNGPETMRMS-----RGGCSGLLRCGKGTTYEGGVREPALA 298 Query: 383 RWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFL 442 WP I G E S++D+ PT+A LAGAPLP + +DG DL PLL G + +S + L Sbjct: 299 FWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTLDGFDLSPLLLG-TGKSPRQSL 355 Query: 443 FHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLL 502 F Y +Y + VR T +KA FFT + A H S +T H+PPLL Sbjct: 356 FFY-PSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHAS----SSLTAHEPPLL 410 Query: 503 FDISKDPRERNPL---TPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWL 559 +D+SKDP E L + P + LK +Q + + P Q + P L Sbjct: 411 YDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGE---DPAL 467 Query: 560 QLCC 563 Q+CC Sbjct: 468 QICC 471 >1FSU-A nrPDB Length = 492 Score = 360 bits (922), Expect = 1e-99, Method: Composition-based stats. Identities = 142/586 (24%), Positives = 226/586 (38%), Gaps = 144/586 (24%) Query: 24 ASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFM 83 + P+++ ++ADDLG D G +G++ IRTP++D LA+GGV L + PL TPSR+ + Sbjct: 1 SRPPHLVFLLADDLGWNDVGFHGSR-IRTPHLDALAAGGVLLDNYYTQ-PLATPSRSQLL 58 Query: 84 TGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHS 143 TGRY +R+G+ ++ +P DE +LLK+ GY+T ++GKWHLGM Sbjct: 59 TGRYQIRTGLQH-----QIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKE 113 Query: 144 KTDFCHHPLHHGFNYFYG----------------ISLTNLRDCKPG--EGSVFTTGFKRL 185 P GF+ ++G I N+ C +G TG+K + Sbjct: 114 -----CLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNM 168 Query: 186 VFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMM 245 + T A+ L H P F L L ++ Sbjct: 169 -------YSTNIFTKRAI-ALITNHPPEKPLFLYLALQSV-------------------- 200 Query: 246 RNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQH 305 +E +Q P Y ++ FIQ Sbjct: 201 --HEPLQVPEEY--------LKPYDFIQDKN----------------------------R 222 Query: 306 GVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYK 365 Y V MD +VG + L L N+T+ F++D G + GG+N + Sbjct: 223 HHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQT--------LAGGNNWPLR 274 Query: 366 GGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRD 425 G K + WEGG+R G + P + Q G K E D PT+ KLA + +DG D Sbjct: 275 GRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFD 334 Query: 426 LMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATH 485 + + S E L + ++++ P+NS + K P ++ + + H Sbjct: 335 VWKTISEGSPSPRIELLHNIDPNFVDSSPC-PRNSMAPAKDDSSLPEYSAFNT----SVH 389 Query: 486 VCFCFGSY-----------------------VTHHDPPL----LFDISKDPRERNPLTPA 518 G++ + DPP LFDI +DP ER+ L Sbjct: 390 AAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDL--- 446 Query: 519 SEPRFYEILKVMQEAADRHTQTLP-----EVPDQFSWNNFLWKPWL 559 S + + K++ H ++P + P +W PW+ Sbjct: 447 SREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM 492 >2VQR-A nrPDB Length = 543 Score = 349 bits (895), Expect = 2e-96, Method: Composition-based stats. Identities = 118/548 (21%), Positives = 189/548 (34%), Gaps = 100/548 (18%) Query: 25 SRPNIILVMADDLGIGDP-----GCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSR 79 + N++L++ D ++TPN+DRL GV H+ P+R Sbjct: 31 RKKNVLLIVVDQWRADFVPHVLRADGKIDFLKTPNLDRLCREGVTFRNHVTTCVPAGPAR 90 Query: 80 AAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEI--TFAKLLKDQGYSTALIGKWHL 137 A+ +TG Y + A +P D+ K L+ GY ALIG + Sbjct: 91 ASLLTGLY-------------LMNHRAVQNTVPLDQRHLNLGKALRGVGYDPALIG--YT 135 Query: 138 GMSCHSKTDFCHHPLHH-------GFN-----------YFYGISLT--NLRDCKP----G 173 +T + P GF+ YF ++ +L + +P Sbjct: 136 TTVPDPRTTSPNDPRFRVLGDLMDGFHPVGAFEPNMEGYFGWVAQNGFDLPEHRPDIWLP 195 Query: 174 EGS-VFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLG 232 EG R +P + T T AL +L F Sbjct: 196 EGEDAVAGATDRPSRIPKEFSDSTFFTERALT----------------YLKGRDGKPFFL 239 Query: 233 FLHYFRPLNCFMM-RNYEIIQQP--MSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHV 289 L Y+RP F+ Y + +P M +EAAQ + S+ Sbjct: 240 HLGYYRPHPPFVASAPYHAMYRPEDMPAPIRAANPDIEAAQHPLMKFYVDSIRRGSFFQG 299 Query: 290 HTALFSSKDFAGKSQ-HGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVE 348 ++ D A Q Y + E+D +G++ + LDE +DTLI FTSD G + Sbjct: 300 AEGSGATLDEAELRQMRATYCGLITEVDDCLGRVFSYLDETGQWDDTLIIFTSDHGEQLG 359 Query: 349 EVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRW-PRVIQAGQKIDEPTSNMDIFPTV 407 + GK + R+P +++ +AG T ++D+ PT+ Sbjct: 360 DHHLL-------------GKIGYNDPSFRIPLVIKDAGENARAGAIESGFTESIDVMPTI 406 Query: 408 AKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAF 467 G +P DG L+P L + HY + + PQ Sbjct: 407 LDWLGGKIP--HACDGLSLLPFLSEGRPQDWR-TELHYEYDFRDVYYSEPQ--------- 454 Query: 468 FFTPNFNPVGSNGCFATHVCFCFGSYVTHHD-PPLLFDISKDPRERNPLTPASEPRFYEI 526 +F +G N C + YV PPL FD+ DP E L A +P + + Sbjct: 455 ----SFLGLGMNDCSLCVIQDERYKYVHFAALPPLFFDLRHDPNEFTNL--ADDPAYAAL 508 Query: 527 LKVMQEAA 534 ++ + A Sbjct: 509 VRDYAQKA 516 >2W8S-A nrPDB Length = 543 Score = 346 bits (888), Expect = 1e-95, Method: Composition-based stats. Identities = 119/540 (22%), Positives = 187/540 (34%), Gaps = 86/540 (15%) Query: 26 RPNIILVMADDLGIGDPG----CYGNKT-IRTPNIDRLASGGVKLTQHLAASPLCTPSRA 80 R N++L++ D G + ++TPN+DRL G+ H+ P+RA Sbjct: 32 RKNVLLIVVDQWRADFIPHLMRAEGREPFLKTPNLDRLCREGLTFRNHVTTCVPGGPARA 91 Query: 81 AFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEI--TFAKLLKDQGYSTALIGKWHLG 138 + +TG Y + A +P D+ K L+ GY ALIG Sbjct: 92 SLLTGLY-------------LMNHRAVQNTVPLDQRHLNLGKALRAIGYDPALIG----- 133 Query: 139 MSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGE-------GSVFTTGFKRLVFLPLQ 191 + + F G + R E G V GF+ LP Sbjct: 134 YTTTTPDPRTTSARDPRFTVL-GDIMDGFRSVGAFEPNMEGYFGWVAQNGFE----LPEN 188 Query: 192 IVGVTLLTLAALNCLGLLHVP--------LGVFFS---LLFLAALILTLFLGFLHYFRPL 240 + L + G P FF+ L +L F L Y+RP Sbjct: 189 REDI-WLPEGEHSVPGATDKPSRIPKEFSDSTFFTERALTYLKGRDGKPFFLHLGYYRPH 247 Query: 241 NCFMM-RNYEIIQQP--MSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSK 297 F+ Y + + M + EAAQ + S+ H ++ Sbjct: 248 PPFVASAPYHAMYKAEDMPAPIRAENPDAEAAQHPLMKHYIDHIRRGSFFHGAEGSGATL 307 Query: 298 DFAGKSQ-HGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEI 356 D Q Y + E+D +G++ LDE +DTLI FTSD G + + Sbjct: 308 DEGEIRQMRATYCGLITEIDDCLGRVFAYLDETGQWDDTLIIFTSDHGEQLGDHHLL--- 364 Query: 357 HGGSNGIYKGGKANNWEGGIRVPGILRW-PRVIQAGQKIDEPTSNMDIFPTVAKLAGAPL 415 GK R+P +++ + AGQ + + ++D+ PT+ + G Sbjct: 365 ----------GKIGYNAESFRIPLVIKDAGQNRHAGQIEEGFSESIDVMPTILEWLGGET 414 Query: 416 PEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNP 475 P R DGR L+P L HY + + PQNS + + Sbjct: 415 P--RACDGRSLLPFLAEGKPSDWR-TELHYEFDFRDVFYDQPQNSVQLSQD--------- 462 Query: 476 VGSNGCFATHVCFCFGSYVTHHD-PPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAA 534 C + YV PPL FD+ DP E + L A +P + +++ + A Sbjct: 463 ----DCSLCVIEDENYKYVHFAALPPLFFDLKADPHEFSNL--AGDPAYAALVRDYAQKA 516 >3ED4-A nrPDB Length = 502 Score = 343 bits (878), Expect = 2e-94, Method: Composition-based stats. Identities = 144/567 (25%), Positives = 227/567 (40%), Gaps = 122/567 (21%) Query: 19 AESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPS 78 A + A +PN++++MADDLG GD YG++ ++TPNIDRLA GVK T + A +PL +PS Sbjct: 20 ALAAEAKQPNLVIIMADDLGYGDLATYGHQIVKTPNIDRLAQEGVKFTDYYAPAPLSSPS 79 Query: 79 RAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLG 138 RA +TGR P R+G+ SW +G + L +E+T A LLK QGY TA++GK HL Sbjct: 80 RAGLLTGRMPFRTGIRSWIPSGKDV------ALGRNELTIANLLKAQGYDTAMMGKLHLN 133 Query: 139 MSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLL 198 GF+Y T GF + TL Sbjct: 134 AGGDRTDQ--PQAQDMGFDYSLA----------------NTAGF---------VTDATLD 166 Query: 199 TLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYD 258 G+++ G+L +P P + Sbjct: 167 NAKERPRYGMVYP-------------------TGWLRNGQP-------------TPRADK 194 Query: 259 NLTQRLTVEAAQFIQRNTET-PFLLVLSYLHVHTALFSSK-------------------- 297 + ++ E ++ ++ PF L +++ VH+ L S K Sbjct: 195 MSGEYVSSEVVNWLDNKKDSKPFFLYVAFTEVHSPLASPKKYLDMYSQYMSAYQKQHPDL 254 Query: 298 ---DFAGKSQHGV--YGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSS 352 D+A K GV Y + +D VG++L+ + + ++T++ FTSD G E Sbjct: 255 FYGDWADKPWRGVGEYYANISYLDAQVGKVLDKIKAMGEEDNTIVIFTSDNGPVTREARK 314 Query: 353 KGEIH-GGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLA 411 E++ G +G K N WEGGIRVP I+++ + + G D P +D PT+AK+ Sbjct: 315 VYELNLAGETDGLRGRKDNLWEGGIRVPAIIKYGKHLPQGMVSDTPVYGLDWMPTLAKMM 374 Query: 412 GAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTP 471 LP DR DG L+P+LE K+ + + +F + + WK Sbjct: 375 NFKLPTDRTFDGESLVPVLEQKALKREKPLIFGIDMPFQDDPTDEWAIRDGDWKMIIDRN 434 Query: 472 NFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEIL-KVM 530 N P L+++ D E L ++ K + Sbjct: 435 N-------------------------KPKYLYNLKSDRYETLNLIGKKPDIEKQMYGKFL 469 Query: 531 QEAADRHTQTLP----EVPDQFSWNNF 553 + D +L + P+ +W Sbjct: 470 KYKTDIDNDSLMKARGDKPEAVTWGEG 496 >4CXU-A nrPDB Length = 536 Score = 339 bits (870), Expect = 1e-93, Method: Composition-based stats. Identities = 126/565 (22%), Positives = 215/565 (38%), Gaps = 101/565 (17%) Query: 23 AASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAF 82 + RPN ++++ADDLG D G +G + I TPN+D LA G++LT AS +P+R+ Sbjct: 1 MSKRPNFLVIVADDLGFSDIGTFGGE-IATPNLDALAIAGLRLTDFHTASA-ASPTRSML 58 Query: 83 MTGRYPVRSGMASWSRTGVFLF---TASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGM 139 +TG +G+ + + G L + +LL++ GY T + GKWHLG+ Sbjct: 59 LTGTDHHIAGIGTMAEALTPELEGKPGYEGHLNERVVALPELLREAGYQTLMAGKWHLGL 118 Query: 140 SCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLT 199 P GF + + PG + + P + G L Sbjct: 119 KPEQT------PHARGFERSFAL--------LPGAANHYGFEPPYDESTPRILKGTPALY 164 Query: 200 LAALNCLGLLHVPLGVFFSLLFLAALILT--------LFLGFLHYFRPLNCFMMRNYEII 251 + L L P G + S F L+ F +L + P + EI+ Sbjct: 165 VEDERYLDTL--PEGFYSSDAFGDKLLQYLKERDQSRPFFAYLPFSAPH-WPLQAPREIV 221 Query: 252 QQPMS-YDNLTQRLTVEAAQFIQR----NTETPFLLVLSYLHVHTALFSSKDFAGKSQHG 306 ++ YD + L E ++ + VL+ AL + Sbjct: 222 EKYRGRYDAGPEALRQERLARLKELGLVEADVEAHPVLALTREWEALEDEERAKSARAME 281 Query: 307 VYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAH---VEEVSSKGE------IH 357 VY VE MDW++G++++ L ++T + F SD GA +E G Sbjct: 282 VYAAMVERMDWNIGRVVDYLRRQGELDNTFVLFMSDNGAEGALLEAFPKFGPDLLDFLDR 341 Query: 358 GGSNGIYKGGKANNW-----------------------EGGIRVPGILRWPRVIQAGQKI 394 N + G+AN++ +GGIRVP ++R+PR+ + G Sbjct: 342 HYDNSLENIGRANSYVWYGPRWAQAATAPSRLYKAFTTQGGIRVPALVRYPRLSRQGAIS 401 Query: 395 DEPTSNMDIFPTVAKLAGAPLPEDRII-------DGRDLMPLLEGKSQRSDHEFLFHYCN 447 + MD+ PT+ LAG P R GR + L G+++ + Sbjct: 402 HAFATVMDVTPTLLDLAGVRHPGKRWRGREIAEPRGRSWLGWLSGETEAA---------- 451 Query: 448 AYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISK 507 H +N+ + W F + A ++ G L+D+++ Sbjct: 452 --------HDENTVTGWGLF----GMRAIRQGDWKAVYLPAPVGPAT-----WQLYDLAR 494 Query: 508 DPRERNPLTPASEPRFYEILKVMQE 532 DP E + L + + E+++ + Sbjct: 495 DPGEIHDLADSQPGKLAELIEHWKR 519 >4UPK-A nrPDB Length = 538 Score = 339 bits (869), Expect = 2e-93, Method: Composition-based stats. Identities = 105/537 (19%), Positives = 182/537 (33%), Gaps = 70/537 (13%) Query: 21 SHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRA 80 S + N++ ++ D L + P++ LA V +H + + C PSRA Sbjct: 28 SSMGRQSNVLFIIIDQLRADCLWGALADHVELPHLRALAQDAVSFRRHYSVTNPCGPSRA 87 Query: 81 AFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMS 140 + +TG+Y + L D A ++ GY L G + S Sbjct: 88 SILTGQYAMNHRSVRNG-----------TPLRHDTPNIATEMRKAGYLPLLFG--YTDTS 134 Query: 141 CHSKTDFCHHPLHHGFNY----FYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVT 196 + + P + + F+ ++ L P + + G+ + + + Sbjct: 135 QDPRAYDANDPALKTYEFPMRGFHEVTEMRLEMSYPWQSHLKNRGYAFDDYAQVYVPRPD 194 Query: 197 LLTLAALNCLGLLHVPLG--VFFSLLFLA---ALILTLFLGFLHYFRPLNCFMMRNYEII 251 LN + F + FLA A + L Y RP + Sbjct: 195 ADGTPRLNGPAMYRAEDSDTAFLTDQFLANMPAWAGQNWFAHLTYIRPHP--------PL 246 Query: 252 QQPMSYDNLTQRLTVE-AAQFIQRNT---ETPFLLVLSYLHVHT------ALFSSKDFAG 301 P Y+ + + A+ R+ E PF + D Sbjct: 247 VAPAPYNTMYDPAKLPLPARLPGRDDETAEHPFFGPATRYSSPASFVLGFPDLEPTDETI 306 Query: 302 KSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSN 361 ++ VY E+D +G+++ L E +DTLI T+D G + + S Sbjct: 307 QTLRAVYLGLATEVDTHIGRVIAHLKETGQYDDTLIVVTADHGEMLGDRHS--------- 357 Query: 362 GIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRII 421 GK ++ P I+R P + G ++ PT ++D+ PT+ G +P + Sbjct: 358 ----WGKMTVYDAAYHTPLIIRAPGC-KPGHVVEAPTESIDLMPTILDWVGQEIP--NAV 410 Query: 422 DGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGC 481 DGR L P L G++ ++ F + P + T +W+ F F P Sbjct: 411 DGRSLRPFLTGEAPSDWRQYSFSELDIS------EPLDPT-LWQQEF---GFGPSAGAVA 460 Query: 482 FATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHT 538 F + PP+LFD + RN A +P L + RH Sbjct: 461 ILRDARFTLVEFAADL-PPMLFDHQGEGEFRN---VAGDPAHAADLARLSRQMLRHR 513 >5G2V-A nrPDB Length = 534 Score = 315 bits (806), Expect = 4e-86, Method: Composition-based stats. Identities = 125/563 (22%), Positives = 214/563 (38%), Gaps = 98/563 (17%) Query: 16 LWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLC 75 L + + RPNII +M DD CYG I+TPN+DR+A+ G++ A + L Sbjct: 18 LRQPQKEETKRPNIIFMMTDDHTTQAMSCYGGNLIQTPNMDRIANEGIRFDNCYAVNALS 77 Query: 76 TPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKW 135 PSRA +TG++ +G FT ++ D+ TF KLL+ GY TA+IGKW Sbjct: 78 GPSRACILTGKFSHENG-----------FTDNASTFNGDQQTFPKLLQQAGYQTAMIGKW 126 Query: 136 HLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLR-DCKPGEGSVFTTGFKRLVFLPLQIVG 194 HL GF+++ +S + + D + + I Sbjct: 127 HLISEP------------QGFDHWSILSGQHEQGDYYDPDFWEDGKHIVEKGYATDIITD 174 Query: 195 --VTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQ 252 + L N + A L +F + P N F Sbjct: 175 KAINFLENRDKNKPFCMMYHQKAPHRNWMPAPRHLGIFNNTIFP-EPANLFDDYEGRGKA 233 Query: 253 QPMSYDNLTQRLTVEA-AQFIQRN---TETPFLLVLSYLHVHTALFSSKD---------- 298 ++ LT + + + R +T L Y + + + D Sbjct: 234 AREQDMSIEHTLTNDWDLKLLTREEMLKDTTNRLYSVYKRMPSEVQDKWDSAYAQRIAEY 293 Query: 299 ------------FAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAH 346 + + Y V +D ++G++LN L+++ ++T+I +TSDQG Sbjct: 294 RKGDLKGKALISWKYQQYMRDYLATVLAVDENIGRLLNYLEKIGELDNTIIVYTSDQGFF 353 Query: 347 VEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPT 406 + E K +E R+P I+R+P+ I+AG + N+D PT Sbjct: 354 LGEHGWF-------------DKRFMYEECQRMPLIIRYPKAIKAGSTSSAISMNVDFAPT 400 Query: 407 VAKLAGAPLPEDRIIDGRDLMPLL--EGKSQRSDHEFLFHYCNAYL--NAVRWHPQNSTS 462 AG +P D I G L P+L EGK+ + +++ Y ++V+ H T Sbjct: 401 FLDFAGVEVPSD--IQGASLKPVLENEGKTPADWRKAAYYHYYEYPAEHSVKRHYGIRTQ 458 Query: 463 IWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASE-- 520 +K F D ++D+ DPRE N + +E Sbjct: 459 DFKLIHF------------------------YNDIDEWEMYDMKADPREMNNIFGKAEYA 494 Query: 521 PRFYEILKVMQEAADRHTQTLPE 543 + E++++++E ++ P+ Sbjct: 495 KKQKELMQLLEETQKQYKDNDPD 517 >4UPH-A nrPDB Length = 547 Score = 297 bits (759), Expect = 1e-80, Method: Composition-based stats. Identities = 113/542 (20%), Positives = 186/542 (34%), Gaps = 64/542 (11%) Query: 17 WEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCT 76 W + RPN++L+ AD G+ +++TPN+D LA GV T+H A + + Sbjct: 38 WRP---SGKRPNVLLISADQWRGDCLSAVGHASVKTPNVDALAQDGVLFTRHFAGTAPAS 94 Query: 77 PSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEI--TFAKLLKDQGYSTALIGK 134 P+RA TG Y + G P D A + GY L G Sbjct: 95 PARATLYTGLYQMN-------------HRVCRNGSPLDARFDNLALAARRGGYDPTLFG- 140 Query: 135 WHLGMSCHSKTDFCHHPLHHGFN-YFYGISLTNL--RDCKPGEGSVFTTGFKRLVFLPLQ 191 + + + + P + G S L K + + G + Sbjct: 141 -YTDTAPDPRGMDPNDPHLTTYEGVLPGFSARQLLPEHEKQWLSWLRSRGHPEATSRDIH 199 Query: 192 IVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILT---LFLGFLHYFRPLNCF-MMRN 247 I + F + + + + RP F + Sbjct: 200 IPVGATPGEISDVAPAYSKDETQTAFLAGEFIRWLGEQDAPWFAHVSFLRPHPPFSVPEP 259 Query: 248 YEIIQQPMSYDNLTQRLTVEAAQ--FIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQ- 304 Y + P + EA Q P + S+++ S S Sbjct: 260 YNRMFTPSDGPAFARAANREAEQAVHPLLAFALPLIGKDSFIYGGEGSASDWTSEDLSAI 319 Query: 305 HGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIY 364 +Y + E+D +G+I L + +DTLI FTSD + + + Sbjct: 320 RAIYYGMIAEVDTQLGRIWQALKNVGAWDDTLIIFTSDHAEMMGDH-------------W 366 Query: 365 KGGKANNWEGGIRVPGILRWPRVI-QAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDG 423 GK ++G VP ++R P AG++++ TS DIFPT+ G L D +DG Sbjct: 367 MLGKGGFFDGSYHVPLVIRDPGHPGGAGRQVERFTSAADIFPTLCDRLG--LVPDNHLDG 424 Query: 424 RDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFA 483 L+P LEG + F + + + + + + SN C Sbjct: 425 GTLVPFLEGGEPEGWRDAAFWEFD-FRDIAKGEAERHFGL-------------KSNACNL 470 Query: 484 THVCFCFGSYVTHHD-PPLLFDISKDPRERNPLTPASEPRFYEI---LKVMQEAADRHTQ 539 + YV PPLL+D++KDP E + ++ + K++ A Q Sbjct: 471 AVIRDERFKYVHFAGLPPLLYDLAKDPMELTNVAADADYAAVRLGYAEKLLSLRAQHLDQ 530 Query: 540 TL 541 TL Sbjct: 531 TL 532 >6BIA-A nrPDB Length = 477 Score = 289 bits (738), Expect = 3e-78, Method: Composition-based stats. Identities = 124/521 (23%), Positives = 201/521 (38%), Gaps = 101/521 (19%) Query: 17 WEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCT 76 + + +PNIIL++ADDLG D G G+K I TPNID LA G + A P C Sbjct: 17 RGSHMASEQKPNIILIVADDLGYADVGFNGSKDIITPNIDDLAKSGTSFSDAYVAHPFCG 76 Query: 77 PSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWH 136 PSRAA MTGRYP + G T S+ G+PTD +KLL + Y T +GKWH Sbjct: 77 PSRAALMTGRYPHKIGSQFNLPT-----RGSNVGVPTDAKFISKLLNENNYFTGALGKWH 131 Query: 137 LGMSCHSKTDFCHHPLHHGFNYFYGI---SLTNLRDCKPGEGSVFTTGFKRLVFLPLQIV 193 +G + HHP GF+ +YG D + + +F + + Sbjct: 132 MGDTPQ------HHPNKRGFDEYYGFLGGGHNYFPDQYQPQYKKQKAQGLKNIFEYITPL 185 Query: 194 GVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQ 253 + + V F + F +L Y P Sbjct: 186 EHNGKEVKETQYITDALSREAVNFVDKAVNKK--HPFFLYLAYNAPHTP----------- 232 Query: 254 PMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVE 313 ++ + + Y V Sbjct: 233 -----------------LQAKDEDMAMFPNI----------------KNKDRKTYAGMVY 259 Query: 314 EMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWE 373 +D VG+++ L + ++TLI F SD G + + G +N K GK + E Sbjct: 260 AVDRGVGKLVEALKKNNQYDNTLIVFMSDNGGKLSK--------GANNFPLKAGKGSTQE 311 Query: 374 GGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMP-LLEG 432 GG RVP + WP+ + AG++ P S +D++PT A LAGA + E++ +DG ++ P ++ Sbjct: 312 GGFRVPMLFHWPKHVPAGKRFSHPVSALDLYPTFAALAGAKVEENQHLDGTNMWPAFIKN 371 Query: 433 KSQRSDHE-FLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFG 491 ++ D + + Y +A + WKA Sbjct: 372 ENPHKDEPIYALRHRKGYSDAA-----IRMNQWKALKVNQ-------------------- 406 Query: 492 SYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQE 532 P LF+I D E++ ++ +++ ++++ M++ Sbjct: 407 ------QPWQLFNIENDISEKHDVSKSNKALLTDMVREMEK 441 >4UPL-A nrPDB Length = 569 Score = 286 bits (731), Expect = 2e-77, Method: Composition-based stats. Identities = 113/545 (20%), Positives = 182/545 (33%), Gaps = 86/545 (15%) Query: 28 NIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRY 87 NI+ +M D L CYG+KT+ TP+IDRLA+ GV+ + SP+C SR + TGRY Sbjct: 19 NILFIMFDQLRWDYLSCYGHKTLNTPHIDRLAAKGVRFDRAYIQSPICGSSRMSTYTGRY 78 Query: 88 PVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDF 147 G ASW+ L E+T L+ G L+GK H+ Sbjct: 79 VHSHG-ASWNGIP----------LKVGEMTMGDHLRAAGMGCWLVGKTHMRADEEGMARL 127 Query: 148 CHHP--------LHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTL-- 197 P GF+ F + + + Sbjct: 128 GLEPDSLIGARVAECGFDVFERDDGMLPEGPDGYYDPDGAKEYNKFLRAKGYESDNPWHD 187 Query: 198 -----------------LTLAALNCLGLLHVPLGVFFSLLFLAALILT--LFLGFLHYFR 238 L A + + + + + L Y + Sbjct: 188 FANSGLDDEGNVQSGWFLKNATRPANIAEEDSETPYLTSRAMEFIEQQTGPWCCHLSYIK 247 Query: 239 PLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKD 298 P ++ P Y ++ V+ + L +++ S+ Sbjct: 248 PHWPYI--------VPEPYASMFGPEHVQDVVRSDSERQNAHPLFKAFMDTKVGEAFSRQ 299 Query: 299 FAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHG 358 + Y +++ D +G++ L++ DT+I TSD G + + Sbjct: 300 EVRDAVIPAYMGLIKQADDQMGRLFKWLEDTGRMQDTMIVLTSDHGDFLGDH-------- 351 Query: 359 GSNGIYKGGKANNWEGGIRVPGILRWPRV---IQAGQKIDEPTSNMDIFPTVAKLAGAPL 415 + G K + RVP I+ PR G D ++D+ PT + AG Sbjct: 352 -----WMGEKTFFHDASTRVPLIIYDPRPEADATRGSVCDALVESIDLAPTFVEAAGGK- 405 Query: 416 PEDRIIDGRDLMPLLEGKSQRSDHEFLFH-YCNAYLNAVRWHPQNSTSIWKAFFFTPNFN 474 P I++G L+P+L G DH H C +A N S+ +A F Sbjct: 406 PAMHILEGESLIPILHG---ARDHTLRDHVICEYDFSASPIAHLNDISVRQAVMFM---- 458 Query: 475 PVGSNGCFATHVCFCFGSYVTHHDP-PLLFDISKDPRERNPLTPASEPRFYEILKVMQEA 533 V H DP P+LFD+ DP+E L +P +++ M + Sbjct: 459 -VADKNWKLIHF---------EADPRPMLFDLKNDPQELVDL--GGDPAHADVIAGMYDK 506 Query: 534 ADRHT 538 R T Sbjct: 507 LFRWT 511 >6IOZ-A nrPDB Length = 517 Score = 279 bits (714), Expect = 2e-75, Method: Composition-based stats. Identities = 115/543 (21%), Positives = 200/543 (36%), Gaps = 88/543 (16%) Query: 28 NIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRY 87 N++L++ DDL GCYG+K +R+PNID+LAS + A + PSR +F+TGR Sbjct: 5 NVLLIIVDDLRPS-LGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVAAPSRVSFLTGRR 63 Query: 88 PVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGK-WHLGMSCHSKTD 146 P + + ++ + +G T + K+ GY T +GK +H G+S + D Sbjct: 64 PDTTRLYDFNS----YWRVHAGNFS----TIPQYFKENGYVTMSVGKVFHPGISSNHTDD 115 Query: 147 FCHH---PLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAA- 202 + P +H + Y N + C+ +G + + P+ ++ V TL Sbjct: 116 SPYSWSFPPYHPSSEKY----ENTKTCRGPDGELHAN-----LLCPVDVLDVPEGTLPDK 166 Query: 203 ---LNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDN 259 + LL + S FLA + F + + + N + P D Sbjct: 167 QSTEQAIQLLEK-MKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDG 225 Query: 260 LTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSV 319 L QR + + Y + DF K + Y +V +D V Sbjct: 226 LPPVAYNPWMDIRQREDVQALNISVPYGPIPV------DFQRKIRQS-YFASVSYLDTQV 278 Query: 320 GQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVP 379 G++L+ LD+L+LAN T+I FTSD G + E + K +N++ VP Sbjct: 279 GRLLSALDDLQLANSTIIAFTSDHGWALGEHG-------------EWAKYSNFDVATHVP 325 Query: 380 GILRWPR------------------------VIQAGQKIDEPTSNMDIFPTVAKLAGAPL 415 I P +++ G++ + + +FPT+A LAG + Sbjct: 326 LIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQV 385 Query: 416 PEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHP--------------QNST 461 P + + EGK+ F + YL NS Sbjct: 386 PPRCPVPSFHVELCREGKNLLKHFRFRDLEEDPYLPGNPRELIAYSQYPRPSDIPQWNSD 445 Query: 462 SIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVT---HHDPPLLFDISKDPRERNPLTPA 518 ++ + + V F ++ L+ + DP + + + Sbjct: 446 KPSLKDIKIMGYSIRTIDYRYTVWVGFNPDEFLANFSDIHAGELYFVDSDPLQDHNMYND 505 Query: 519 SEP 521 S+ Sbjct: 506 SQG 508 >4UPI-A nrPDB Length = 576 Score = 279 bits (713), Expect = 2e-75, Method: Composition-based stats. Identities = 105/567 (18%), Positives = 181/567 (31%), Gaps = 86/567 (15%) Query: 23 AASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAF 82 NI+ +M D L CYG++ + TPNID+LA GV+ T + + PSR + Sbjct: 25 MTQNRNILWIMCDQLRFDYLSCYGHERLNTPNIDKLAKRGVRFTNAYVQATVAGPSRMSA 84 Query: 83 MTGRYPVRSGMASWSRTGVFLFTASSGGLPT--DEITFAKLLKDQGYSTALIGKWHL--- 137 TGRY V ++ G+P E T L+D G LIGK H+ Sbjct: 85 YTGRY-------------VRSHGSTQNGIPLRVGEPTLGDHLRDVGMRNVLIGKTHMRPD 131 Query: 138 -----------------------------GMSCHSKTDFCHHPLHHGFNYFYGISLTNLR 168 H P ++ + G N Sbjct: 132 LDGMKRLGIDPDSEIGARVGEGGFDAFDRDDGVHPTGYRKKEPAYNDYLRHAGFQAENPW 191 Query: 169 DCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILT 228 + S G + L + + F A Sbjct: 192 EF--WANSAEGKGGENQSGWLLTHADKPARVPEEHSETAYMTRRAMEFMEA---AEKDGR 246 Query: 229 LFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLH 288 + L Y +P ++ P Y ++ V+ A + L + Sbjct: 247 PWCAHLSYIKPHWPYI--------VPAPYHDMFGPDDVKPAVRSDEELKAAHPLFKAMTE 298 Query: 289 VHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVE 348 + ++D + Y ++++D +GQ+ + E L +T+I FT+D G ++ Sbjct: 299 EVYSRNFARDEVREKVIPAYMGLIKQIDDQLGQLFAFMQERGLDENTMIVFTADHGDYLG 358 Query: 349 EVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVI---QAGQKIDEPTSNMDIFP 405 + + G K +E +VP I+ P G D +D+ P Sbjct: 359 DH-------------WMGEKYLFYEAAAKVPLIIYDPSDKADATRGTVSDALVEMIDLAP 405 Query: 406 TVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWK 465 T AG +P I++G+ L+PLL D +++F + R + Sbjct: 406 TFVDYAGG-VPPMHILEGKSLLPLLHDDDSSWDRQYVFSELDYSNLPARLKLGRDIQDCR 464 Query: 466 AFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDP---RERNPLTPASEPR 522 A + F + DP L D+ +DP R LT A + Sbjct: 465 ATMV------FDGRYKLVEVMGFAPILFDLEVDPDELKDLGRDPSAEEVRQRLTSALDAW 518 Query: 523 FYEILKVMQEAADRHTQTLPEVPDQFS 549 + + ++ + P + + Sbjct: 519 HRNTRQRITKSDAAYRALDPVLRESDP 545 >2QZU-A nrPDB Length = 491 Score = 277 bits (708), Expect = 1e-74, Method: Composition-based stats. Identities = 107/543 (19%), Positives = 187/543 (34%), Gaps = 99/543 (18%) Query: 18 EAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTP 77 +A+ + PN++ +MAD GC G + ++TP++D+LAS G+ T +++ P+ +P Sbjct: 20 QAQEKQPT-PNLVFIMADQYRGDAIGCIGKEPVKTPHLDKLASEGINFTNAISSYPVSSP 78 Query: 78 SRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHL 137 +R MTG YP+ S + + + L + ++ +LKDQGY+ IGKWHL Sbjct: 79 ARGMLMTGMYPIGSKVTGNCNSETAPYGVE---LSQNARCWSDVLKDQGYNMGYIGKWHL 135 Query: 138 GMSCHSKTD------------FCHHPLHHGFNYF--YGISLTNLRDCKPGEGSVFTTGFK 183 D +C HGF+++ YG +L+ + T Sbjct: 136 DAPYKPYVDTYNNRGKVAWNEWCPPERRHGFDHWIAYGTYDYHLKPMY------WNTTAP 189 Query: 184 RLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCF 243 R F + G A+ + F L + G+ Sbjct: 190 RDSFYYVNQWGPEYEASKAIEYINGQKDQKQPFA----LVVSMNPPHTGY---------- 235 Query: 244 MMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKS 303 P Y + + L VEA L + D+ + Sbjct: 236 -------ELVPDRYKEIYKDLDVEA-------------LCKGRPDIPAKGTEMGDYFRNN 275 Query: 304 QHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGI 363 Y + +D +VG+I+ L + L ++T++ FTSD G + Sbjct: 276 IRN-YYACITGVDENVGRIIEALKQNNLFDNTIVVFTSDHGICMGAHE------------ 322 Query: 364 YKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDG 423 GK +E +R+P IL WP I+ + + D++PT+ + G + Sbjct: 323 -NAGKDIFYEESMRIPMILSWPDQIKPRKSDPLMIAFADLYPTLLSMMGFSKEIPETVQT 381 Query: 424 RDLM-PLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCF 482 DL +L GK+++ + + T + Sbjct: 382 FDLSNEVLTGKNKKDLVQPYYFVKF------------------DNHATGYRGLRTDRYTY 423 Query: 483 ATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLP 542 A H V +LFD + DP E N + + + + P Sbjct: 424 AVHATDGKIDNV------ILFDRTNDPHEMNNIASQQLKLTHTFNRQL--KTWLEKTNDP 475 Query: 543 EVP 545 Sbjct: 476 FAQ 478 >4MHX-A nrPDB Length = 510 Score = 228 bits (580), Expect = 6e-60, Method: Composition-based stats. Identities = 112/562 (19%), Positives = 189/562 (33%), Gaps = 108/562 (19%) Query: 24 ASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFM 83 A N +L++ADD G G Y N I TP++D LA + + +PSRA+ + Sbjct: 20 ARPRNALLLLADDGGFES-GAYNNSAIATPHLDALARRSLLFRNAFTSVSSSSPSRASLL 78 Query: 84 TGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHS 143 TG ++GM + + + LL G T +IGK H+G Sbjct: 79 TGLPQHQNGMYGLHQDVHHFNSFDK------VRSLPLLLSQAGVRTGIIGKKHVG----- 127 Query: 144 KTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAAL 203 + F++ Y + N GSV G I + LL Sbjct: 128 ------PETVYPFDFAY--TEEN--------GSVLQVG--------RNITRIKLLVRK-- 161 Query: 204 NCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQR 263 FL F ++ + P C + + + Sbjct: 162 -----------------FLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGM 204 Query: 264 LTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQIL 323 + + + + L V F A ++ V MD VG +L Sbjct: 205 GRIP--DWTPQAYDP--------LDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVL 254 Query: 324 NLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILR 383 L + + NDTL+ FTSD G + G+ N + G P ++ Sbjct: 255 QELRDAGVLNDTLVIFTSDNG-----------------IPFPSGRTNLYWPGTAEPLLVS 297 Query: 384 WPRVIQA-GQKIDEPTSNMDIFPTVAKLAGAPLPEDR-------IIDGRDLMPLLEGKS- 434 P + GQ + S +D+ PT+ P P + GR L+P LE + Sbjct: 298 SPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPL 357 Query: 435 ------QRSDHEFLFHYCNAYLNAVRWHPQNSTS------IWKAFFFTPNFNPVGSNGCF 482 +S HE Y + + ++ + I + F+ +P F + + Sbjct: 358 WATVFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTA 417 Query: 483 ATHVCFCFG-SYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQE--AADRHTQ 539 + + + L+D S+DP E L A++PRF ++L+++++ A + Sbjct: 418 GQPTGWYKDLRHYYYRARWELYDRSRDPHETQNL--ATDPRFAQLLEMLRDQLAKWQWET 475 Query: 540 TLPEVPDQFSWNNFLWKPWLQL 561 P V P Q Sbjct: 476 HDPWVCAPDGVLEEKLSPQCQP 497 >5G2T-A nrPDB Length = 489 Score = 220 bits (561), Expect = 9e-58, Method: Composition-based stats. Identities = 106/518 (20%), Positives = 177/518 (34%), Gaps = 92/518 (17%) Query: 23 AASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAF 82 +PN +++ D L G YG T ID +AS GV + PL PSRAA Sbjct: 20 QQEKPNFLIIQCDHLTQRVVGAYGQTQGCTLPIDEVASRGVIFSNAYVGCPLSQPSRAAL 79 Query: 83 MTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCH 142 +G P ++ + S S V + LP + T L + GY GK H Sbjct: 80 WSGMMPHQTNVRSNSSEPV------NTRLPENVPTLGSLFSESGYEAVHFGKTH--DMGS 131 Query: 143 SKTDFCHHPLHHGF-NYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLA 201 + P+ F + + ++ + D E +V L P + Sbjct: 132 LRGFKHKEPVAKPFTDPEFPVNNDSFLDVGTCEDAV-----AYLSNPPKEPFICIADFQN 186 Query: 202 ALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLT 261 N G + GV G L + F + ++ I P+ Y + Sbjct: 187 PHNICGFIGENAGVHTD---------RPISGPLP--ELPDNFDVEDWSNIPTPVQYICCS 235 Query: 262 QRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQ 321 R +AA + + N + ++ H Y V + V Sbjct: 236 HRRMTQAAHWNEENYRH---YIAAFQH-------------------YTKMVSK---QVDS 270 Query: 322 ILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGI 381 +L L +T++ +D G + + + ++ VP I Sbjct: 271 VLKALYSTPAGRNTIVVIMADHGDGMASHRMVTKHI------------SFYDEMTNVPFI 318 Query: 382 LRWPRVIQAGQKIDEPTS--NMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDH 439 P + Q + +D + +D+ PT+ LAG +P ++ G L P L G+ Q+ H Sbjct: 319 FAGPGIKQQKKPVDHLLTQPTLDLLPTLCDLAGIAVPAEKA--GISLAPTLRGEKQKKSH 376 Query: 440 EFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDP 499 ++ WH + + TP G + TH G Sbjct: 377 PYV---------VSEWHSEYE------YVTTPGRMVRGPRYKY-THYLEGNGE------- 413 Query: 500 PLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRH 537 L+D+ KDP ER L A +P++ +IL + D + Sbjct: 414 -ELYDMKKDPGERKNL--AKDPKYSKILAEHRALLDDY 448 >4UG4-A nrPDB Length = 515 Score = 212 bits (539), Expect = 3e-55, Method: Composition-based stats. Identities = 115/536 (21%), Positives = 180/536 (33%), Gaps = 102/536 (19%) Query: 26 RPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTG 85 +PNI+++M D L + PN+ LA + + +SPLC P+RA+FM G Sbjct: 8 KPNILIIMVDQLNGKLFPDGPADFLHAPNLKALAKRSARFHNNYTSSPLCAPARASFMAG 67 Query: 86 RYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKT 145 + P R+ + + +P T+A L+ GY TAL GK H Sbjct: 68 QLPSRTRVYDNAAE-------YQSSIP----TYAHHLRRAGYYTALSGKMH--------- 107 Query: 146 DFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNC 205 F HGF D P + G+ P + + L ++ Sbjct: 108 -FVGPDQLHGFEERL------TTDIYPAD-----FGWTPDYRKPGERIDWWYHNLGSVTG 155 Query: 206 LGLLHVPLGVFFSL--LFLAALILT------------LFLGFLHYFRPLNCFMMRNYEII 251 G+ + + + FLA L + + + P + ++ R + Sbjct: 156 AGVAEITNQMEYDDEVAFLANQKLYQLSRENDDESRRPWCLTVSFTHPHDPYVAR-RKFW 214 Query: 252 QQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDA 311 ++LT + E L F + + Y Sbjct: 215 DLYEDCEHLTPEVGAIPLD------EQDPHSQRIMLSCDYQNFDVTEENVRRSRRAYFAN 268 Query: 312 VEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANN 371 + +D VG++++ L R+ +DTLI F SD G + E K N Sbjct: 269 ISYLDEKVGELIDTLTRTRMLDDTLILFCSDHGDMLGERGL-------------WFKMNF 315 Query: 372 WEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDR-IIDGRDLMPLL 430 +EG RVP ++ P I G + PTSN+D+ PT+A LAG L E R DG L+P++ Sbjct: 316 FEGSARVPLMIAGPG-IAPGLHL-TPTSNLDVTPTLADLAGISLEEVRPWTDGVSLVPMV 373 Query: 431 EGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCF 490 G L Y ++ + Sbjct: 374 NG--VERTEPVLMEY-----------------------------AAEASYAPLVAIREGK 402 Query: 491 GSYVT-HHDPPLLFDISKDPRERNPLTPASE-PRFYEILKVMQEAADRHTQTLPEV 544 YV DP LFD+ DP E L P L ++ H Sbjct: 403 WKYVYCALDPEQLFDLEADPLELTNLAENPRGPVDQATLTAFRDMRAAHWDMEAFD 458 >3LXQ-A nrPDB Length = 450 Score = 133 bits (333), Expect = 2e-31, Method: Composition-based stats. Identities = 89/469 (18%), Positives = 145/469 (30%), Gaps = 119/469 (25%) Query: 9 PFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQH 68 P LL ++ R N+++++ + LG G G + TPN+D L G + TQ Sbjct: 68 PTLLPTMNSNPATYQGKRKNLVILLQESLGAQFVGSLGGLPL-TPNLDELMQEGWQFTQM 126 Query: 69 LAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYS 128 A A TG P S SR V L + +G T A LLK+QGY Sbjct: 127 YATGTRSVRGIEAVTTGFPP------SPSRAVVKLSKSQTGFF-----TIADLLKEQGYH 175 Query: 129 TALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFL 188 T I + F + G G V + G Sbjct: 176 TQFI-----------YGGEANFDNMKTFFFGNGFDQIVEEKNYTNPGFVGSWG------- 217 Query: 189 PLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNY 248 + L A L FFSL+F ++ N+ Sbjct: 218 ---VSDEDLYNKADEE-FERLSKGDKPFFSLVFTSS----------------------NH 251 Query: 249 EIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVY 308 + P +E S+H Sbjct: 252 SPYEYPEG--------KIEQYD--------------------------------SEHMTR 271 Query: 309 GDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGK 368 +AV+ D+++G + + +DT+ +D A V + H Sbjct: 272 NNAVKYSDYALGTFFDKAKKSSYWDDTIFIVIADHDARVFGANLVPVKH----------- 320 Query: 369 ANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMP 428 +P ++ + IQ +K D +N+D+ PT+ L G I GRDL Sbjct: 321 -------FHIPALI-IGKDIQP-RKDDRIANNIDMPPTLLSLIGVDAKTPMI--GRDLTK 369 Query: 429 LLEGKSQRSDHEFLFHYCNAYLN-AVRWHPQNSTSIWKAFFFTPNFNPV 476 L + +R+ ++ ++ + V P S + F + P+ Sbjct: 370 PLAREDERAMMQYDKNFGYLTRDNLVVLSPGEKVSTMEYDFESQTMKPL 418 >4UOP-A nrPDB Length = 442 Score = 79.2 bits (193), Expect = 5e-15, Method: Composition-based stats. Identities = 58/336 (17%), Positives = 118/336 (35%), Gaps = 31/336 (9%) Query: 138 GMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTL 197 G S D + + +F +S +N D E SV+T+ F + Q G + Sbjct: 79 GQSITPTLDGLQNETMYSNQFFQTVSKSNTADA---EWSVYTSTFPSGYYTNTQTYGDRV 135 Query: 198 LT-LAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMS 256 + + L F +GF ++ R + + + Sbjct: 136 IPSMPRLLGKNDYKTATFHTNDASFYNRDEFYPAVGFDKFYD-------RKFFGDEDVIG 188 Query: 257 YDNLTQRLTVEAAQFIQR--NTETPFLLVLSYLHVHTALFSSKDFAGK--------SQHG 306 + + L +A ++ F L + H KD ++ G Sbjct: 189 FSPSDEVLYNKAFPILEEQYKNNQKFYAQLISVSSHMPFDIPKDKQEIDLPSDLKDTELG 248 Query: 307 VYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQG-AHVEEVSSKGEIHGGSNGIYK 365 Y +AV D +G+ + L + + +D+++ F D +++ + + + + K Sbjct: 249 NYFEAVHYADKQLGEFIQKLKDSGIWDDSVVVFYGDHHIIKTDQLPEEQKKYVNRSTQLK 308 Query: 366 GGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRD 425 A+++ R+P L +P + G+ + +DI PTV L G D+I+ G D Sbjct: 309 AEPADDY----RIPFFLHYPGMENPGEIKNVGGE-IDIMPTVMNLLGIKT-GDQIMFGTD 362 Query: 426 LMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNST 461 +L + + + + N+ + P S Sbjct: 363 ---ILNSSNNYVPERYTMPEGSYFTNSYMYQPDESF 395 Score = 34.9 bits (78), Expect = 0.089, Method: Composition-based stats. Identities = 32/169 (18%), Positives = 54/169 (31%), Gaps = 22/169 (13%) Query: 23 AASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRA-- 80 AA N+I+V + N TP +D L + + Q + A Sbjct: 54 AAKGKNLIIVQLESFQRNLTNVKINGQSITPTLDGLQNETMYSNQFFQTVSKSNTADAEW 113 Query: 81 AFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMS 140 + T +P SG + ++T S +LL Y TA H + Sbjct: 114 SVYTSTFP--SGYYTNTQTYGDRVIPS----------MPRLLGKNDYKTATF---HTNDA 158 Query: 141 CHSKTDFCHHPLHHGFNYFYG---ISLTNLRDCKPGEGSVFTTGFKRLV 186 D + + GF+ FY ++ P + ++ F L Sbjct: 159 SFYNRDEFYPAV--GFDKFYDRKFFGDEDVIGFSPSDEVLYNKAFPILE 205 >5I5H-A nrPDB Length = 586 Score = 75.0 bits (182), Expect = 8e-14, Method: Composition-based stats. Identities = 31/189 (16%), Positives = 68/189 (35%), Gaps = 25/189 (13%) Query: 241 NCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQR--NTETPFLLVLSYLHVHTALFSSKD 298 + P ++ + ++ R + + +S+ + + + Sbjct: 352 PLYRQALLSDFSMPSVRTQSDEQTATQWINWLGRYAQEDNRWFSWVSFNGTNIDDSNQQA 411 Query: 299 FAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHG 358 FA K Y A +D + ++LN L + ++T++ T+ +G + E + Sbjct: 412 FARK-----YSRAAGNVDDQINRVLNALRDSGKLDNTVVIITAGRGIPLSEEEETFDWSH 466 Query: 359 GSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAK-LAGAPLPE 417 G ++VP ++ WP Q+I+ T + D+ T+ + L P Sbjct: 467 GH---------------LQVPLVIHWPG--TPAQRINALTDHTDLMTTLMQRLLHVSTPA 509 Query: 418 DRIIDGRDL 426 G+DL Sbjct: 510 SEYSQGQDL 518 >5I5F-A nrPDB Length = 586 Score = 72.3 bits (175), Expect = 6e-13, Method: Composition-based stats. Identities = 29/189 (15%), Positives = 72/189 (38%), Gaps = 25/189 (13%) Query: 241 NCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQR--NTETPFLLVLSYLHVHTALFSSKD 298 + P + + + ++ R + + +S+ + + K+ Sbjct: 352 PLYRQALLSDFSMPAAQTQSDAQTASQWIDWLGRYAQEDNRWFSWISFNGTNIDDSNQKN 411 Query: 299 FAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHG 358 F + Y A ++D + ++LN L E ++T++ T+ +G + ++ + Sbjct: 412 FVKR-----YASAASDVDAQINRVLNALREAGKFDNTVVIITAGRGIPLTPEENRFDWS- 465 Query: 359 GSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAK-LAGAPLPE 417 +G ++VP ++ WP Q+I+ T + D+ T+ + L P Sbjct: 466 --------------QGHLQVPLVIHWPG--TPAQRINVLTDHTDVMTTLMQRLLHVSTPA 509 Query: 418 DRIIDGRDL 426 + G+D+ Sbjct: 510 NEYSQGQDI 518 >2W8D-A nrPDB Length = 436 Score = 56.5 bits (134), Expect = 3e-08, Method: Composition-based stats. Identities = 35/185 (18%), Positives = 63/185 (34%), Gaps = 23/185 (12%) Query: 278 TPFLLVLSYLHVHTALFSSK--------DFAGKSQHGVYGDAVEEMDWSVGQILNLLDEL 329 PF L H + DF S Y + +D S+ Q N L + Sbjct: 187 QPFYTKFITLSNHFPFGMDEGDTDFPAGDFGD-SVVDNYFQSAHYLDQSIEQFFNDLKKD 245 Query: 330 RLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQ 389 L + ++I D E + G + I A RVP + V Sbjct: 246 GLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQL----QRVPLFIHAAGV-- 299 Query: 390 AGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAY 449 G+K+ + ++D+ PT+ L G +D ++ G D++ + E + + Sbjct: 300 KGEKVHKYAGDVDVAPTILHLLGVDT-KDYLMSGSDIL-------SKEHREVIPFRNGDF 351 Query: 450 LNAVR 454 ++ Sbjct: 352 ISPKY 356 >4UOO-A nrPDB Length = 459 Score = 54.9 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 34/235 (14%), Positives = 67/235 (28%), Gaps = 24/235 (10%) Query: 183 KRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNC 242 + L + G+ + + + +A+ + F + Sbjct: 115 DSEMLLENSLYGLPQGSAFTTKGQNTYESASAILGQQGYTSAVFHGNYKSFWNRDEIYKQ 174 Query: 243 FMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTE------TPFLLVLSYLHVHTALFSS 296 F N+ + ++ F + + E PF L H Sbjct: 175 FGYDNFFDASYYDMNEADVSNYGLKDKPFFKESEEYLSSLQQPFYTKFITLTNHFPYPID 234 Query: 297 KDFA-------GKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEE 349 + A G S Y +D SV ++ L + L ++++I D Sbjct: 235 EKDASIAPATTGDSSVDTYFQTARYLDESVKSFVDYLKKSGLYDNSVIIMYGDH------ 288 Query: 350 VSSKGEIHGGSNGIYKGGKANNWEG--GIRVPGILRWPRVIQAGQKIDEPTSNMD 402 + H + G N +E RVP ++ P V G ++ +D Sbjct: 289 -YGISDNHEEAMTKILGKDYNTFENAQAQRVPLMIHVPGV--QGGVQEQYGGQVD 340 >2W5S-A nrPDB Length = 424 Score = 53.0 bits (125), Expect = 4e-07, Method: Composition-based stats. Identities = 34/185 (18%), Positives = 64/185 (34%), Gaps = 23/185 (12%) Query: 273 QRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGV-------YGDAVEEMDWSVGQILNL 325 Q ++PF L L H + A + Y +D ++ + +N Sbjct: 182 QAKMKSPFYSHLITLTNHYPFTLDEKDATIEKSNTGDATVDGYIQTARYLDEALEEYIND 241 Query: 326 LDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWP 385 L + L ++++I D E ++ E G N R ++ P Sbjct: 242 LKKKGLYDNSVIMIYGDHYGISENHNNAMEKLLGEKITPAKFTDLN-----RTGFWIKIP 296 Query: 386 RVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDL--------MPLLEGKSQRS 437 ++G +E +D+ PT+ LAG + G DL +P G Sbjct: 297 G--KSGGINNEYAGQVDVMPTILHLAGIDTKNYLMF-GTDLFSKGHNQVVPFRNGDFITK 353 Query: 438 DHEFL 442 D++++ Sbjct: 354 DYKYV 358 >1O99-A nrPDB Length = 511 Score = 50.7 bits (119), Expect = 2e-06, Method: Composition-based stats. Identities = 34/208 (16%), Positives = 66/208 (31%), Gaps = 31/208 (14%) Query: 222 LAALILTLFLGFLHYFRPLNCFMMRNYEIIQQP--MSYDNLTQRLTVEAAQFIQRNTETP 279 +A + F F + +I P +YD + E + + E Sbjct: 331 IAETEKYPHVTFFMSGGREEEFPGEDRILINSPKVPTYDLKPEMSAYEVTDALLKEIEAD 390 Query: 280 FLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYF 339 Y + + + AVE +D +G++++ + + Sbjct: 391 -----KYDAIILNYANPDMVGHSGKLEPTIKAVEAVDECLGKVVDAILAKG----GIAII 441 Query: 340 TSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTS 399 T+D G + GK VP I+ + G K+ + Sbjct: 442 TADHG-------------NADEVLTPDGKPQTAHTTNPVPVIV-----TKKGIKLRDGGI 483 Query: 400 NMDIFPTVAKLAGAPLPEDRIIDGRDLM 427 D+ PT+ L G LP+ + + G+ L+ Sbjct: 484 LGDLAPTMLDLLG--LPQPKEMTGKSLI 509 >5XWI-A nrPDB Length = 567 Score = 50.3 bits (118), Expect = 2e-06, Method: Composition-based stats. Identities = 50/338 (14%), Positives = 90/338 (26%), Gaps = 38/338 (11%) Query: 23 AASRPNIIL-VMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCT--PSR 79 AA+ P +I+ + D Y + T + RL S G + + P Sbjct: 36 AATPPKLIVAISVDQFSADLFSEY--RQYYTGGLKRLTSEGAVFPRGYQSHAATETCPGH 93 Query: 80 AAFMTGRYPVRSGMASWS-------RTGVFLFTASSGGLPTDEI----TFAKLLKDQGYS 128 + +TG P R+G+ + + R L+ A P LK Sbjct: 94 STILTGSRPSRTGIIANNWFDLDAKREDKNLYCAEDESQPGSSSDKYEASPLHLK----V 149 Query: 129 TALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFL 188 L G+ G + + +G V +K + Sbjct: 150 PTLGGRMKAANPATRVVSVAG--KDRAAIMMGGATADQVWWLGGPQGYV---SYKGVAPT 204 Query: 189 PLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNY 248 PL +P + A T+ G + R + Sbjct: 205 PLVTQVNQAFAQRLAQPNPGFELPAQCVSKDFPVQAGNRTVGTG--RFARDAGDYKGFRI 262 Query: 249 EIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVY 308 Q M+ + + L + HT + + Sbjct: 263 SPEQDAMTLAFAAAAIENMQLGKQAQTDIISIGLSATDYVGHTFGTEGTESCIQVDR--- 319 Query: 309 GDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAH 346 +D +G + LD+ + D ++ T+D G H Sbjct: 320 ------LDTELGAFFDKLDKDGI--DYVVVLTADHGGH 349 Score = 33.8 bits (75), Expect = 0.22, Method: Composition-based stats. Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 7/60 (11%) Query: 369 ANNWEGGIRVPGILRWPRVIQAGQKIDEP--TSNMDIFPTVAKLAGAPLPEDRIIDGRDL 426 + W+ RVP + + Q ++P +DI P++A L P+P+D+ IDGR L Sbjct: 492 GSPWDTDRRVPILFW----RKGMQHFEQPLGVETVDILPSLAALIKLPVPKDQ-IDGRCL 546 >4LR8-A nrPDB Length = 416 Score = 45.3 bits (105), Expect = 7e-05, Method: Composition-based stats. Identities = 29/120 (24%), Positives = 47/120 (39%), Gaps = 24/120 (20%) Query: 299 FAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHG 358 F + YG+A++E D + ++ L E D L+ T+D G Sbjct: 311 FGHRRDPQGYGEALQEYDARLPEVFAKLKE-----DDLLLITADHG-------------- 351 Query: 359 GSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPED 418 N G + E VP + P + + GQ++ + DI TVA+ G +PE Sbjct: 352 --NDPIHPGTDHTRE---YVPLLAYSPSMKEGGQELPLRQTFADIGATVAENFGVKMPEY 406 >4QAX-A nrPDB Length = 513 Score = 43.4 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 23/121 (19%), Positives = 44/121 (36%), Gaps = 30/121 (24%) Query: 311 AVEEMDWSVGQILNLLDELRLANDTLIYFTSDQG---AHVEEVSSKGEIHGGSNGIYKGG 367 A+E +D +G++++ + ++ D T+D G + + H + Sbjct: 419 AIEAVDECLGEVVDKILDM----DGYAIITADHGNSDQVLTDDDQPMTTHTTNP------ 468 Query: 368 KANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLM 427 VP I+ + G + E D+ PT+ L PED + G L+ Sbjct: 469 ----------VPVIV-----TKEGVTLRETGRLGDLAPTLLDLLNVEQPED--MTGESLI 511 Query: 428 P 428 Sbjct: 512 K 512 >5UDY-A nrPDB Length = 422 Score = 42.6 bits (98), Expect = 4e-04, Method: Composition-based stats. Identities = 18/79 (22%), Positives = 31/79 (39%), Gaps = 6/79 (7%) Query: 19 AESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHL-AASPLCTP 77 S+ ++LV D ++ + TPN+D +A GVK A + +P Sbjct: 12 PVQSQGSQNKLLLVSFDGFRWNY-----DQDVDTPNLDAMARDGVKARYMTPAFVTMTSP 66 Query: 78 SRAAFMTGRYPVRSGMASW 96 +TG+Y G+ Sbjct: 67 CHFTLVTGKYIENHGVVHN 85 Score = 33.0 bits (73), Expect = 0.39, Method: Composition-based stats. Identities = 15/100 (15%), Positives = 34/100 (34%), Gaps = 10/100 (10%) Query: 311 AVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKAN 370 V ++D +VG + + L + + TSD G + + G++ + Sbjct: 204 MVRQVDRTVGYLRESIARNHLTDRLNLIITSDHGMTTVDKRA-GDLVEFHKFPNFTFRDI 262 Query: 371 NWEGGIRVPGILRWPR---VIQAGQKIDEPTSNMDIFPTV 407 +E + P + + G+ + D P + Sbjct: 263 EFE------LLDYGPNGMLLPKEGRLEKVYDALKDAHPKL 296 >3E2D-A nrPDB Length = 502 Score = 42.6 bits (98), Expect = 5e-04, Method: Composition-based stats. Identities = 55/348 (15%), Positives = 101/348 (29%), Gaps = 60/348 (17%) Query: 24 ASRPNIILVMADDLGIGDPGCYGNKTIRTPN---------IDRLASGGVKLT------QH 68 A N+IL++ D +G G + PN I +LA GV + Sbjct: 1 AEIKNVILMIGDGMGPQQVGLLETYANQAPNSIYKGNKTAIYQLAQEGVIGSSLTHPEDA 60 Query: 69 LAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYS 128 + C+ + TG Y S + V + + T + K G + Sbjct: 61 IVVDSACSAT--MLATGIY---------SSSEVIGIDSQGNHV----ETVLEKAKKAGKA 105 Query: 129 TALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFL 188 T L+ L + + F H H + G + K Sbjct: 106 TGLVSDTRL--THATPASFAAHQPHRSLENQIASDMLATGADVMLSGGLRHWIPKSTNDK 163 Query: 189 PLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNY 248 + LT + L + L L + + Y Sbjct: 164 GETYKQLEKLTQGDV-YLKSKRKDDRNLLTEAEKDGYQLAFNRNMLDDAKGDKLLGLFAY 222 Query: 249 EIIQQPMSYDNLTQR----------LTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKD 298 + ++Y N + +T +A + ++ + FL+V D Sbjct: 223 SGMDDGIAYSNKKKSGERTQPSLKEMTQKALNILSKDEDGFFLMV---------EGGQID 273 Query: 299 FAGKSQHGVYGDAVEEM---DWSVGQILNLLDELRLANDTLIYFTSDQ 343 +AG S G + E+ D ++ + + DT++ T+D Sbjct: 274 WAGHSNDA--GTMLHELLKFDEAIQTVYEWAKDR---EDTIVIVTADH 316 >5VPU-A nrPDB Length = 523 Score = 42.2 bits (97), Expect = 5e-04, Method: Composition-based stats. Identities = 41/239 (17%), Positives = 75/239 (31%), Gaps = 35/239 (14%) Query: 194 GVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQ 253 + + L + + L +A + F + + +I Sbjct: 311 DAPVAYMPEELKNSLGEYLSSLGKTQLRIAETEKYAHVTFFFSGGREDEYPGEKRILIPS 370 Query: 254 P--MSYDNLTQRLTVEAAQFIQR---NTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVY 308 P +YD + E + + + E L+V D A K Sbjct: 371 PNVATYDLKPEMSAYEVTDELVKAINSGEYDLLVVNYANGDMVGHTGVFDAAVK------ 424 Query: 309 GDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGK 368 AVE +D +G++ + +A + T+D G + Y+ G+ Sbjct: 425 --AVEAVDTCLGRVYEAV----MAKKGHMLITADHG------------NVEQMQDYESGQ 466 Query: 369 ANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLM 427 + VP I P I E D+ PT+ L P+P + + GR+L+ Sbjct: 467 VHTQHTTELVPFIYVGPTQAT----IAEGGVLADVAPTILNLMQIPVPAE--MQGRNLI 519 >2W5W-A nrPDB Length = 375 Score = 40.3 bits (92), Expect = 0.002, Method: Composition-based stats. Identities = 20/101 (19%), Positives = 31/101 (30%), Gaps = 13/101 (12%) Query: 294 FSSKDFAGKSQHGVYGDAVEEM---DWSVGQILNLLDELRLANDTLIYFTSDQ--GAHVE 348 S D+ G + + Y + E+ D ++G L + +TL+ TSD G Sbjct: 255 GSQIDWGGHANNASY--LISEINDFDDAIGTALAFAKKDG---NTLVIVTSDHETGGFTL 309 Query: 349 EVSSKGEIHGGSNGIYKGGKANNWEGG---IRVPGILRWPR 386 G Y GG +P P Sbjct: 310 AAKKNKREDGSEYSDYTEIGPTFSTGGHSATLIPVFAYGPG 350 >4LR2-A nrPDB Length = 401 Score = 39.9 bits (91), Expect = 0.003, Method: Composition-based stats. Identities = 14/72 (19%), Positives = 24/72 (33%), Gaps = 3/72 (4%) Query: 273 QRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLA 332 N+ P Y A K ++++D +G ++ L L L Sbjct: 156 LNNSNPPVTFATLYWEEPDASGHKYGPEDKENMSR---VLKKIDDLIGDLVQRLKMLGLW 212 Query: 333 NDTLIYFTSDQG 344 + + TSD G Sbjct: 213 ENLNVIITSDHG 224 >5VEN-A nrPDB Length = 416 Score = 38.0 bits (86), Expect = 0.011, Method: Composition-based stats. Identities = 10/36 (27%), Positives = 20/36 (55%) Query: 309 GDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQG 344 G + ++D +G ++ +L +L N+ + TSD G Sbjct: 191 GSVISDVDHKLGYLIKMLKRAKLWNNVNLIVTSDHG 226 >4AGS-A nrPDB Length = 471 Score = 37.2 bits (84), Expect = 0.022, Method: Composition-based stats. Identities = 38/231 (16%), Positives = 71/231 (30%), Gaps = 17/231 (7%) Query: 203 LNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQ 262 + + V +S LF + L F+ + + QP Y + Sbjct: 242 ESAPMMGANGGHVLYSNLFCPFVDRARLASELRKFQMH----IVEVPLHPQPEWYKYINP 297 Query: 263 RLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGD-AVEEMDWSVGQ 321 R TV A L++ Y+ S+ G ++ VE + VG Sbjct: 298 RDTVPALFTPSGEAVHESQLIVQYIDCVATKGSALVPRGDAEKEYEVGFFVENAGYFVGG 357 Query: 322 ILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGI 381 +++ + ++ E+ + H G + GGK N +P + Sbjct: 358 LMSWIIRGGEDAK------AELQWAAGELEQQLAKHPFGEGPFFGGKRMNAGDVAILPFL 411 Query: 382 LRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEG 432 +R A + E + D+F L G + + + LE Sbjct: 412 VR------AKAFMPEFSGGYDLFAHFPLLNGLAEAGMATPEAKSVFRTLEE 456 >5MX9-A nrPDB Length = 324 Score = 36.8 bits (83), Expect = 0.024, Method: Composition-based stats. Identities = 24/135 (17%), Positives = 41/135 (30%), Gaps = 12/135 (8%) Query: 280 FLLVLSYLHVHTALFSSKDFAG---KSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTL 336 F T + + A +S Y +A+ D + + ++ L D Sbjct: 184 FKRYDEQFAKFTPVCEGNELAKCEHQSLINAYDNALLATDDFIAKSIDWLKTHEANYDVA 243 Query: 337 IYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDE 396 + + SD G + E +HG N + VP D Sbjct: 244 MLYVSDHGESLGENGVY--LHGMPNAFAPKEQR-------AVPAFFWSNNTTFKPTASDT 294 Query: 397 PTSNMDIFPTVAKLA 411 ++ I PT+ KL Sbjct: 295 VLTHDAITPTLLKLF 309 >5YLE-A nrPDB Length = 334 Score = 36.8 bits (83), Expect = 0.027, Method: Composition-based stats. Identities = 27/137 (19%), Positives = 43/137 (31%), Gaps = 15/137 (10%) Query: 280 FLLVLSYLHVHTALFSSKDFAG---KSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTL 336 F T + + A +S Y +A+ D + Q + L A D Sbjct: 185 FKRYDEKFAKFTPVCEGNELAKCEHQSLINAYDNALLATDDFIAQSIQWLQTHSNAYDVS 244 Query: 337 IYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRV--IQAGQKI 394 + + SD G + E +HG N + + VP + I Sbjct: 245 MLYVSDHGESLGENGVY--LHGMPNAFAPKEQRS-------VPAFFWTDKQTGITPMATD 295 Query: 395 DEPTSNMDIFPTVAKLA 411 T + I PT+ KL Sbjct: 296 TVLTHDA-ITPTLLKLF 311 >5VEM-A nrPDB Length = 416 Score = 34.5 bits (77), Expect = 0.12, Method: Composition-based stats. Identities = 10/36 (27%), Positives = 20/36 (55%) Query: 309 GDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQG 344 G + ++D +G ++ +L + +L N + TSD G Sbjct: 191 GPVISDIDKKLGYLIQMLKKAKLWNTLNLIITSDHG 226 >4B56-A nrPDB Length = 820 Score = 34.1 bits (76), Expect = 0.17, Method: Composition-based stats. Identities = 18/98 (18%), Positives = 32/98 (32%), Gaps = 15/98 (15%) Query: 264 LTVEAAQFIQRNTETPFLLVL----SYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSV 319 +E Q + L L S H H + S A ++++D V Sbjct: 248 AVLEWLQLPSHERPHFYTLYLEEPDSSGHSHGPVSSEVIKA-----------LQKVDRLV 296 Query: 320 GQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIH 357 G +++ L +L L + SD G ++ Sbjct: 297 GMLMDGLKDLGLDKCLNLILISDHGMEQGSCKKYVYLN 334 Score = 29.1 bits (63), Expect = 5.6, Method: Composition-based stats. Identities = 16/76 (21%), Positives = 24/76 (31%), Gaps = 4/76 (5%) Query: 22 HAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCT-PSRA 80 P +L D +G P I +L + G P T P+ Sbjct: 101 AEFESPPTLLFSLDGFRAEYLHTWGGLL---PVISKLKNCGTYTKNMRPMYPTKTFPNHY 157 Query: 81 AFMTGRYPVRSGMASW 96 + +TG YP G+ Sbjct: 158 SIVTGLYPESHGIIDN 173 >6G4G-A nrPDB Length = 840 Score = 33.8 bits (75), Expect = 0.23, Method: Composition-based stats. Identities = 21/90 (23%), Positives = 34/90 (37%), Gaps = 5/90 (5%) Query: 18 EAESHAA-SRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCT 76 E + +P +IL D + PNI++L + G+ A P T Sbjct: 106 EPQCPEGFDQPPVILFSMDGFRAEYLQTWSTLL---PNINKLKTCGLHSKYMRAVYPTKT 162 Query: 77 -PSRAAFMTGRYPVRSGMASWSRTGVFLFT 105 P+ +TG YP G+ + V+L Sbjct: 163 FPNHYTIVTGLYPESHGIIDNNMYDVYLNK 192 >5EGE-A nrPDB Length = 429 Score = 33.0 bits (73), Expect = 0.35, Method: Composition-based stats. Identities = 37/288 (12%), Positives = 83/288 (28%), Gaps = 44/288 (15%) Query: 248 YEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGV 307 Y + + + D +A ++ + + V + K Sbjct: 153 YCLEYKTVPTDINFANAVSDALDSLKSGRADLAAIYHERIDVEGHHYGPSSPQRK----- 207 Query: 308 YGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGG 367 DA+ +D + ++ + + L D + SD G + ++ ++ SN I Sbjct: 208 --DALRAVDTVLKYMIQWIQDRGLQQDLNVILFSDHG--MTDIFWMDKVIELSNYISL-- 261 Query: 368 KANNWEGGIRVPGILRWPRVIQAGQKIDEP--TSNMDIF-----PTVAKLAGAPLPEDRI 420 + + R P + WP + + + +M ++ P Sbjct: 262 -DDLQQVKDRGPVVSLWPVPGKHSEIYHKLRTVEHMTVYEKESIPNRFYYKKGKFVSPLT 320 Query: 421 I---------DGRDLMPLL------EGKSQRSDHEF----------LFHYCNAYLNAVRW 455 + + R+++P QR H + + + R Sbjct: 321 LVADEGWFIAESREMLPFWMNSTGKREGWQRGWHGYDNELMDMRGIFLAIGPDFKSNFRA 380 Query: 456 HPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLF 503 P S ++ P+ +NG ++ V G + L F Sbjct: 381 APIRSVDVYNIMAHVAGITPLPNNGSWSRVVSMLKGQTSSASRENLYF 428 >5JTL-E nrPDB Length = 471 Score = 32.6 bits (72), Expect = 0.50, Method: Composition-based stats. Identities = 19/117 (16%), Positives = 42/117 (35%), Gaps = 20/117 (17%) Query: 233 FLHYFRPLNCFMMRNY-EIIQQPMSYDNLT--QRLTVEAAQFIQRNTETPFLLVLSYLHV 289 +L + + + P D++ ++T +A + + +N + +L V Sbjct: 290 WLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEK------GFFLQV 343 Query: 290 HTALFSSKDFAGKSQHGVYGDAVEE---MDWSVGQILNLLDELRLANDTLIYFTSDQ 343 A +D A + E +D +V + L + +TL+ T+D Sbjct: 344 EGASIDKQDHAANP-----CGQIGETVDLDEAVQRALEFAKKEG---NTLVIVTADH 392 >5X3I-A nrPDB Length = 743 Score = 31.8 bits (70), Expect = 0.78, Method: Composition-based stats. Identities = 21/112 (18%), Positives = 30/112 (26%), Gaps = 19/112 (16%) Query: 409 KLAGAPLPED------RIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTS 462 LAG P R MP+++ H H+ + WH +T Sbjct: 565 DLAGFSGPVPDAELYLRAAAASAFMPIMQ------YHSEFNHHQLPLRDRTPWHVAETTG 618 Query: 463 IWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLL----FDISKDPR 510 P F + + D PL+ FD DP Sbjct: 619 ---DDRVVPLFRRFATLRESLVPYLTEQAARTIATDRPLMRPLFFDHENDPE 667 >3WKX-A nrPDB Length = 669 Score = 31.5 bits (69), Expect = 1.0, Method: Composition-based stats. Identities = 23/115 (20%), Positives = 37/115 (32%), Gaps = 3/115 (2%) Query: 36 DLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMAS 95 D+ DP Y K ++ N D + + P R + VR G Sbjct: 222 DVRGQDPQFYA-KQLKAMNGDNIFHDLGFYKPTYFQA--AEPVRDQQTADGHAVRVGYLC 278 Query: 96 WSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHH 150 V G + T + + ++ + Y T IG H+G S D + Sbjct: 279 TGVAHVGRLLGDQGLIDTAKRFWKNIVTRRMYVTGAIGSTHVGESFTYDYDLPND 333 >5OLB-A nrPDB Length = 844 Score = 30.7 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 11/33 (33%), Positives = 20/33 (60%) Query: 312 VEEMDWSVGQILNLLDELRLANDTLIYFTSDQG 344 + E+D +VGQ+++ L +L+L + F D G Sbjct: 297 LREIDKTVGQLMDGLKQLKLHRCVNVIFVGDHG 329 Score = 29.9 bits (65), Expect = 2.8, Method: Composition-based stats. Identities = 21/73 (28%), Positives = 29/73 (39%), Gaps = 4/73 (5%) Query: 26 RPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCT-PSRAAFMT 84 RP +I+ D G+K + PNI++L S G P T P+ T Sbjct: 131 RPPLIIFSVDGFRASYMKK-GSKVM--PNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLAT 187 Query: 85 GRYPVRSGMASWS 97 G YP G+ S Sbjct: 188 GLYPESHGIVGNS 200 >5MHP-A nrPDB Length = 871 Score = 30.3 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 21/73 (28%), Positives = 29/73 (39%), Gaps = 4/73 (5%) Query: 26 RPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCT-PSRAAFMT 84 RP +I+ D G+K + PNI++L S G P T P+ T Sbjct: 163 RPPLIIFSVDGFRASYMKK-GSKVM--PNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLAT 219 Query: 85 GRYPVRSGMASWS 97 G YP G+ S Sbjct: 220 GLYPESHGIVGNS 232 >4OKD-A nrPDB Length = 840 Score = 29.9 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 24/138 (17%), Positives = 37/138 (26%), Gaps = 23/138 (16%) Query: 200 LAALNCLGLLHVPLGVFFSLLFLAALILTLFL---GFLHYFRPLNCFMMRNYEIIQQPMS 256 + G+ H V +A L + L Y +M P Sbjct: 143 EEDKDYPGMRHDKRRVVLDPYAVAVLNRRRWGQMGPNLPYGEEGVLGVM--------PTW 194 Query: 257 YDNLTQRLTVEAAQFIQRNTETPFLLV---LSYLHVHTALFSSKDFAGKSQHGVYGDAVE 313 + F +TP L L H F++ +G + G Y VE Sbjct: 195 PQAAAALPAARGSAF-DWEGDTPLNLPMESLVIYEAHVRGFTAHASSGVAAPGTYAGMVE 253 Query: 314 EMDWSVGQILNLLDELRL 331 +D L L + Sbjct: 254 RLD--------YLKSLGV 263 >5XGU-B nrPDB Length = 645 Score = 29.9 bits (65), Expect = 3.4, Method: Composition-based stats. Identities = 36/196 (18%), Positives = 64/196 (32%), Gaps = 24/196 (12%) Query: 275 NTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDW--SVGQILNLLDELR-- 330 L+Y V L +D Y V+ ++ ++ ++L+ E R Sbjct: 292 EAVMSSHARLTYTKVWHILQGDQDL-----REQYAPLVKHLEELHNLYKVLDKAREERGG 346 Query: 331 ---LANDTLIYFTSDQGAHVEEVSSKGEIHG---GSNGIYKGGKANNWEGGIRVPGILRW 384 + + F +++ E + + + H + A E + P + R Sbjct: 347 ISFESEEAKFIFNAERRIERIEQTQRNDAHKLIEECMILANISAARFVEKA-KEPALFR- 404 Query: 385 PRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFH 444 I + TS F +V G LP + RD LLE + R D E L Sbjct: 405 ---IHDKPSTEAITS----FRSVLAELGLELPGGNKPEPRDYAELLESVADRPDAEMLQT 457 Query: 445 YCNAYLNAVRWHPQNS 460 + + P+N Sbjct: 458 MLLRSMKQAIYDPENR 473 >6C01-A nrPDB Length = 838 Score = 29.5 bits (64), Expect = 3.7, Method: Composition-based stats. Identities = 20/80 (25%), Positives = 30/80 (37%), Gaps = 4/80 (5%) Query: 27 PNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCT-PSRAAFMTG 85 P +IL D + PNI++L + G+ A P T P+ +TG Sbjct: 122 PPVILFSMDGFRAEYLYTWDTLM---PNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTG 178 Query: 86 RYPVRSGMASWSRTGVFLFT 105 YP G+ + V L Sbjct: 179 LYPESHGIIDNNMYDVNLNK 198 >3OH0-A nrPDB Length = 641 Score = 29.1 bits (63), Expect = 5.3, Method: Composition-based stats. Identities = 21/136 (15%), Positives = 40/136 (29%), Gaps = 8/136 (5%) Query: 1 MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLAS 60 +P+ L ++L A+ +++ +DD + PN+ L Sbjct: 137 LPVETATNTTYLAYYLRWAQRVGGKEVPFVIMTSDDTHDRTLQLLRELQLEVPNLHVL-K 195 Query: 61 GGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMAS----WSRTGVFLFTASSGGLPTDEI 116 G +A+ L + R P G + + S G T + Sbjct: 196 QGQVFCFADSAAHLALDETGKLL--RKPHGHGDVHSLIYNATVKRDVVPDSGDGTATAQP 253 Query: 117 TFAKLLKDQGYSTALI 132 L GY + + Sbjct: 254 LVNDWL-AAGYESIVF 268 >4IWS-A nrPDB Length = 518 Score = 28.8 bits (62), Expect = 6.6, Method: Composition-based stats. Identities = 19/105 (18%), Positives = 36/105 (34%), Gaps = 5/105 (4%) Query: 32 VMADDLGIGDPGCYGNKTIRTPN--IDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPV 89 ++ + G G YG ++TP+ D + G + L + L P+ G Sbjct: 160 LLHEQDGGRYFGTYGFHVVQTPDGSWDSWSVGRLMLVD---RNTLAGPTIPTQHIGIIRE 216 Query: 90 RSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGK 134 + A L + + + + GY AL+G+ Sbjct: 217 QWRRLGKPTPWAMALGAPPAALAAAGMPLPEGVSEAGYVGALVGE 261 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.306 0.112 0.276 Lambda K H 0.267 0.0341 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 19,134,367 Number of Sequences: 36641 Number of extensions: 736455 Number of successful extensions: 2075 Number of sequences better than 10.0: 55 Number of HSP's better than 10.0 without gapping: 53 Number of HSP's successfully gapped in prelim test: 27 Number of HSP's that attempted gapping in prelim test: 1808 Number of HSP's gapped (non-prelim): 126 length of query: 583 length of database: 10,336,785 effective HSP length: 102 effective length of query: 481 effective length of database: 6,599,403 effective search space: 3174312843 effective search space used: 3174312843 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 61 (28.4 bits)