BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P08684 (503 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 6DA2-A nrPDB 994 0.0 5VEU-A nrPDB 842 0.0 6C94-A nrPDB 171 8e-43 3MDV-A nrPDB 144 8e-35 4R20-A nrPDB 142 3e-34 4H1N-A nrPDB 134 6e-32 4KPA-A nrPDB 134 1e-31 5YLW-A nrPDB 132 3e-31 3K9V-A nrPDB 128 6e-30 5W0C-A nrPDB 126 3e-29 3DL9-A nrPDB 121 8e-28 2PG7-A nrPDB 121 8e-28 5UYS-A nrPDB 120 1e-27 5E58-A nrPDB 119 2e-27 2NNH-A nrPDB 119 2e-27 4GQS-A nrPDB 119 5e-27 1N6B-A nrPDB 114 9e-26 4R1Z-A nrPDB 113 2e-25 5VBU-A nrPDB 113 2e-25 6B82-A nrPDB 113 2e-25 2VE3-A nrPDB 112 4e-25 3QZ1-A nrPDB 111 7e-25 5E0E-A nrPDB 111 9e-25 3E6I-A nrPDB 110 1e-24 3JUS-A nrPDB 105 4e-23 3IBD-A nrPDB 105 5e-23 3MZS-A nrPDB 103 1e-22 3N9Z-A nrPDB 101 8e-22 2HI4-A nrPDB 101 8e-22 2W0A-A nrPDB 99 4e-21 6DWN-A nrPDB 98 9e-21 3TBG-A nrPDB 98 1e-20 6AYB-A nrPDB 97 2e-20 3EL3-A nrPDB 92 4e-19 6M7X-A nrPDB 87 2e-17 6IQ5-A nrPDB 86 3e-17 4ZGX-A nrPDB 86 5e-17 6CR2-A nrPDB 79 7e-15 3P3Z-A nrPDB 78 9e-15 3S79-A nrPDB 77 2e-14 2WX2-A nrPDB 76 4e-14 6B11-A nrPDB 73 3e-13 4WMZ-A nrPDB 72 4e-13 4OQS-A nrPDB 71 1e-12 4Z5P-A nrPDB 71 1e-12 1Z8P-A nrPDB 70 2e-12 4OQR-A nrPDB 70 3e-12 4GGV-A nrPDB 70 3e-12 5JLC-A nrPDB 69 4e-12 3L4D-A nrPDB 68 1e-11 4UBS-A nrPDB 67 2e-11 2X2N-A nrPDB 67 2e-11 2VZM-A nrPDB 65 1e-10 1WIY-A nrPDB 64 1e-10 6DCD-A nrPDB 64 1e-10 4RM4-A nrPDB 64 1e-10 5CJE-A nrPDB 64 1e-10 2Z36-A nrPDB 64 2e-10 5VWS-A nrPDB 64 2e-10 3ABB-A nrPDB 64 2e-10 3MGX-A nrPDB 63 2e-10 5OFQ-A nrPDB 63 2e-10 5L94-A nrPDB 62 4e-10 4WPZ-A nrPDB 62 7e-10 5FSA-A nrPDB 62 8e-10 5NWS-A nrPDB 61 1e-09 3BUJ-A nrPDB 61 1e-09 3A50-A nrPDB 61 1e-09 1UE8-A nrPDB 60 2e-09 6A7I-A nrPDB 59 3e-09 5FYF-A nrPDB 59 5e-09 1GWI-A nrPDB 59 6e-09 5XNT-A nrPDB 59 6e-09 3AWQ-A nrPDB 59 6e-09 2WIO-A nrPDB 59 7e-09 4YT3-A nrPDB 58 8e-09 5YSW-A nrPDB 58 8e-09 3EJB-B nrPDB 58 1e-08 5XW2-A nrPDB 57 1e-08 3OFT-A nrPDB 57 2e-08 3NC3-A nrPDB 57 2e-08 4JBT-A nrPDB 57 2e-08 6HQW-A nrPDB 57 3e-08 1F4U-A nrPDB 57 3e-08 3R9C-A nrPDB 56 4e-08 3WVS-A nrPDB 55 5e-08 6A7J-A nrPDB 55 6e-08 2Y5N-A nrPDB 55 6e-08 3NV6-A nrPDB 55 6e-08 6HQG-A nrPDB 55 8e-08 6GK6-A nrPDB 55 8e-08 3SN5-A nrPDB 54 1e-07 2ZBZ-A nrPDB 54 1e-07 6FYJ-A nrPDB 54 1e-07 5HDI-A nrPDB 54 2e-07 2ZQJ-A nrPDB 53 2e-07 3TKT-A nrPDB 52 5e-07 2XKR-A nrPDB 52 5e-07 5FOI-A nrPDB 52 5e-07 3RWL-A nrPDB 52 8e-07 6F0B-A nrPDB 51 9e-07 1Q5D-A nrPDB 51 9e-07 3TYW-A nrPDB 51 1e-06 4Z5Q-A nrPDB 51 1e-06 5LIV-A nrPDB 50 2e-06 4TRI-A nrPDB 50 2e-06 5XJN-A nrPDB 50 2e-06 5GWE-A nrPDB 50 2e-06 5YHJ-A nrPDB 50 2e-06 3ABA-A nrPDB 50 3e-06 6F88-A nrPDB 50 3e-06 5H1Z-A nrPDB 49 4e-06 4MM0-A nrPDB 49 4e-06 2RFC-A nrPDB 49 4e-06 4YZR-A nrPDB 49 5e-06 1ODO-A nrPDB 49 5e-06 5KYO-A nrPDB 49 7e-06 1CPT-A nrPDB 47 2e-05 5Y1I-A nrPDB 47 2e-05 3WEC-A nrPDB 47 2e-05 5DE9-A nrPDB 47 2e-05 5IT1-A nrPDB 47 2e-05 6G71-A nrPDB 47 2e-05 5LIE-A nrPDB 47 3e-05 4PWV-A nrPDB 46 3e-05 5HIW-A nrPDB 46 3e-05 5M0P-A nrPDB 46 5e-05 1UED-A nrPDB 45 7e-05 2WM5-A nrPDB 45 8e-05 2RCM-A nrPDB 45 1e-04 2FR7-A nrPDB 45 1e-04 6HQD-A nrPDB 44 1e-04 3A1L-A nrPDB 44 2e-04 6CVC-A nrPDB 44 2e-04 2WIY-A nrPDB 43 3e-04 4XE3-A nrPDB 43 4e-04 6M7L-A nrPDB 43 4e-04 5Z9I-A nrPDB 42 4e-04 4DO1-A nrPDB 42 5e-04 2NZA-A nrPDB 42 5e-04 6GMF-A nrPDB 42 5e-04 5DQN-A nrPDB 42 6e-04 3B98-A nrPDB 42 7e-04 1LG9-A nrPDB 41 0.001 5L1U-A nrPDB 40 0.002 2IAG-A nrPDB 40 0.003 3OO3-A nrPDB 39 0.005 3IVY-A nrPDB 39 0.005 5OMS-A nrPDB 39 0.006 2UUQ-A nrPDB 39 0.007 4C9K-A nrPDB 38 0.009 2X9P-A nrPDB 38 0.009 2IJ7-A nrPDB 38 0.011 5D3U-A nrPDB 37 0.014 5EX6-C nrPDB 36 0.044 6GII-A nrPDB 36 0.050 1EHE-A nrPDB 35 0.060 6FSH-A nrPDB 35 0.100 4TX3-A nrPDB 35 0.11 5EX8-A nrPDB 34 0.13 3DBM-A nrPDB 34 0.18 1DXF-A nrPDB 33 0.35 2H57-A nrPDB 32 0.86 6ERI-Az nrPDB 31 1.5 1IS1-A nrPDB 30 1.8 5MLC-9 nrPDB 30 2.0 6BLD-A nrPDB 30 2.1 3J8B-C nrPDB 30 2.8 1EH1-A nrPDB 30 3.5 2YJN-B nrPDB 29 3.8 5A5T-C nrPDB 29 4.4 >6DA2-A nrPDB Length = 487 Score = 994 bits (2569), Expect = 0.0, Method: Compositional matrix adjust. Identities = 481/483 (99%), Positives = 482/483 (99%) Query: 21 LLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQP 80 + YLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQP Sbjct: 1 MAYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQP 60 Query: 81 VLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG 140 VLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG Sbjct: 61 VLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG 120 Query: 141 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ 200 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ Sbjct: 121 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ 180 Query: 201 DPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESR 260 DPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESR Sbjct: 181 DPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESR 240 Query: 261 LEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYE 320 LEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYE Sbjct: 241 LEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYE 300 Query: 321 LATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKD 380 LATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKD Sbjct: 301 LATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKD 360 Query: 381 VEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPR 440 VEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPR Sbjct: 361 VEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPR 420 Query: 441 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTV 500 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTV Sbjct: 421 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTV 480 Query: 501 SGA 503 SGA Sbjct: 481 SGA 483 >5VEU-A nrPDB Length = 480 Score = 842 bits (2175), Expect = 0.0, Method: Compositional matrix adjust. Identities = 400/477 (83%), Positives = 437/477 (91%), Gaps = 1/477 (0%) Query: 22 LYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPV 81 + LYGT +HGLFK+LGIPGPTPLP LGN+LSY +G FD EC+KKYGK+WG Y+GQ PV Sbjct: 1 MALYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPV 60 Query: 82 LAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGK 141 LAITDPD+I+TVLVKECYSVFTNRR GPVGFMKSAIS+AEDEEWKR+RSLLSPTFTSGK Sbjct: 61 LAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGK 120 Query: 142 LKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQD 201 LKEM PIIAQYGDVLVRNLRREAE GKPVTLKD+FGAYSMDVIT TSFGVNIDSLNNPQD Sbjct: 121 LKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQD 180 Query: 202 PFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRL 261 PFVE+TKK L+F FLDP FLSI +FPFL P+ E LN+ +FP++ NFL KSV RMK+SRL Sbjct: 181 PFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRL 240 Query: 262 EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYEL 321 D QKHR+DFLQLMIDSQNSKETESHKALSDLEL AQSIIFIFAGYETTSSVLSF +YEL Sbjct: 241 NDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL 300 Query: 322 ATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDV 381 ATHPDVQQKLQ+EIDAVLPNKAPPTYD V+QMEYLDMVVNETLRLFP+A+RLER CKKDV Sbjct: 301 ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDV 360 Query: 382 EINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441 EING+FIPKG +V+IP+YALH DPKYWTEPE+F PERFSKK KD+IDPYIYTPFG+GPRN Sbjct: 361 EINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK-KDSIDPYIYTPFGTGPRN 419 Query: 442 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDG 498 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL GLLQPEKP+VLKV+SRDG Sbjct: 420 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDG 476 >6C94-A nrPDB Length = 497 Score = 171 bits (433), Expect = 8e-43, Method: Compositional matrix adjust. Identities = 115/409 (28%), Positives = 199/409 (48%), Gaps = 26/409 (6%) Query: 82 LAITDPDMIKTVLVK------ECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSP 135 L I +PD K V + + Y F + ++ + + + +W + R LL+P Sbjct: 70 LNIYEPDYAKAVYSRGDPKAPDVYDFF--------LQWIGKGLLVLDGPKWFQHRKLLTP 121 Query: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDS 195 F LK V I A +++ ++A GK + G ++D + +FG Sbjct: 122 GFHYDVLKPYVAIFADSTRIMLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGKGDSG 181 Query: 196 LNNPQDPFVENTKKL--LRFDFLDPFFLSITVFPFLIPI-LEVLNICVFPREVTNFL--- 249 LN+ + +L L +D F +L P L C + T+ + Sbjct: 182 LNHRDSSYYVAVSELTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACRAAHDHTDRVIRQ 241 Query: 250 RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYET 309 RK+ + ++ R + + +DFL +++D + ES LSD +L A+ F+F G++T Sbjct: 242 RKAALQDEKEREKIQNRRHLDFLDILLDVRG----ESGVQLSDTDLRAEVDTFMFEGHDT 297 Query: 310 TSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPI 369 T+S +S+ +Y +A +P+ QQ+ +EE+ +L ++ ++ + +M YL M + E RL+P Sbjct: 298 TTSGISWFLYCMALYPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPP 357 Query: 370 AMRLERVCKKDVE-INGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID 428 ++ R K V ++G +P G ++ + YALHR+ W +PE F P RFS +N Sbjct: 358 VPQVYRQLSKPVSFVDGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRH 417 Query: 429 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL 477 PY + PF +GPRNCIG +FA+ MK+ L F F ++P+KL Sbjct: 418 PYAFIPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFS-VDPLRLPIKL 465 >3MDV-A nrPDB Length = 456 Score = 144 bits (363), Expect = 8e-35, Method: Compositional matrix adjust. Identities = 110/445 (24%), Positives = 210/445 (47%), Gaps = 30/445 (6%) Query: 62 MECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTN-----RRPFGPVGFMKS 116 ++ KKYG V + + +T P+ +K L+ Y+ + + FG F + Sbjct: 17 LDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQG 76 Query: 117 AISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVF 176 +S E W + R ++ F+ L ++ + + LV L +A+ PV+++D+ Sbjct: 77 LVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDML 136 Query: 177 GAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIP----- 231 +MD++ +FG+ L Q P + K +L + S +P Sbjct: 137 TYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLML-----EGITASRNTLAKFLPGKRKQ 191 Query: 232 ILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALS 291 + EV F R+V R V+R +E+ L+ ++ D L ++ ++ A Sbjct: 192 LREVRESIRFLRQVG---RDWVQRRREA-LKRGEEVPADILTQILKAEEG-------AQD 240 Query: 292 DLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL 351 D L+ + F AG+ET+++ L+F + EL+ P++ +LQ E+D V+ +K ++ + Sbjct: 241 DEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLG 300 Query: 352 QMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEP 411 +++YL V+ E+LRL+P A R+ +++ I+G+ +P ++ +Y + R Y+ +P Sbjct: 301 RLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDP 360 Query: 412 EKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET 471 F P+RF + Y PF G R+CIG +FA M +K+ + ++LQ F+ Sbjct: 361 LTFNPDRFGPGAPK--PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQ 418 Query: 472 QIPLKLSLGGLLQPEKPVVLKVESR 496 + L+ L+P PV+ + R Sbjct: 419 RFGLQEQ--ATLKPLDPVLCTLRPR 441 >4R20-A nrPDB Length = 486 Score = 142 bits (359), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 122/443 (27%), Positives = 201/443 (45%), Gaps = 38/443 (8%) Query: 67 KYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSA---ISIAE- 122 +YG ++G Y G L +++ +++ VL++ F R + I+ A+ Sbjct: 51 QYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGRE-FAGRPKMVTTDLLTQGGKDIAFADY 109 Query: 123 DEEWKRLRSLLSPTFT-----SGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFG 177 WK R L+ +FT S KL+ I+ + D L L +A G+ L V Sbjct: 110 SPLWKNHRRLVHSSFTLFGEGSNKLQT---IVQEAADSLCEEL--QACRGQSSDLSVVLM 164 Query: 178 AYSMDVITSTSFGVNIDSLNNPQDPFVENT--------KKLLRFDFLDPFFLSITVFPFL 229 +VI F S P DP ++ + + R +D F + +FP Sbjct: 165 RAVTNVICRLVF----SSSYQPSDPELQTVIQYNDGIVQTIARGGLVD-IFPWLRIFPN- 218 Query: 230 IPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKA 289 L+ L CV R+ + K++ E + T D L ++ Q + Sbjct: 219 -KDLKRLKECVSIRDQLLY-----KKLLEHKKSLTPGEPRDLLDALLIGQQRGSGGADDI 272 Query: 290 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 349 D L+ + F AG ETTS+ L + + L HP +Q+++Q E+D + PP Sbjct: 273 TEDHVLMTAAEAF-GAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSD 331 Query: 350 VLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYW 408 + LD V+ E +R+ P++ + + V +D + G +PKG V++ +A+H DPK+W Sbjct: 332 RPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHW 391 Query: 409 TEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPC 468 +PE+F PERF + + + PFG+GPR C+G A + + L + R LQ FSF Sbjct: 392 DQPEQFNPERFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFSCP 451 Query: 469 KETQIP-LKLSLGGLLQPEKPVV 490 E +P L+ G +LQPE+ V Sbjct: 452 SEASLPDLQGRFGVVLQPERYTV 474 >4H1N-A nrPDB Length = 479 Score = 134 bits (338), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 125/455 (27%), Positives = 189/455 (41%), Gaps = 57/455 (12%) Query: 39 PGPTPLPFLGNILSY-HKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 97 PGP+PLP LGN+L KG + +KYG V+ Y G +PV+ + D I+ LV + Sbjct: 13 PGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLCGTDAIREALVDQ 72 Query: 98 CYSVFTNRRPFGPVG--FMKSAISIAEDEEWKRLRSLLSPT---FTSGKLKEMVPIIAQY 152 F+ R V F + A E W+ LR T F GK + + I + Sbjct: 73 A-EAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRFSLATMRDFGMGK-RSVEERIQEE 130 Query: 153 GDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR 212 LV LR+ TL +F + + ++I S FG R Sbjct: 131 ARCLVEELRKSKGALLDNTL--LFHSITSNIICSIVFGK--------------------R 168 Query: 213 FDFLDPFFLSI----------------TVFPFLIPILEVL-----NICVFPREVTNFLRK 251 FD+ DP FL + VF L+ I +E+ F+ + Sbjct: 169 FDYKDPVFLRLLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQ 228 Query: 252 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTS 311 SV++ + + D R DF+ + + +++ L+ + AG ETTS Sbjct: 229 SVEKHRATL--DPSNPR-DFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTS 285 Query: 312 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP-IA 370 + L + + +P V +++Q+EI+ V+ + PP D +M Y D V++E RL I Sbjct: 286 TTLRYGFLLMLKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIP 345 Query: 371 MRLERVCKKDVEINGMFIPKGVVVM-IPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP 429 + KD + G IPK V + S ALH DP+Y+ P F P F N Sbjct: 346 FGVPHTVTKDTQFRGYVIPKNTEVFPVLSSALH-DPRYFETPNTFNPGHFLDANGALKRN 404 Query: 430 YIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS 464 + PF G R C+G A + L +LQNFS Sbjct: 405 EGFMPFSLGKRICLGEGIARTELFLFFTTILQNFS 439 >4KPA-A nrPDB Length = 494 Score = 134 bits (337), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 115/395 (29%), Positives = 187/395 (47%), Gaps = 37/395 (9%) Query: 119 SIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGA 178 S ++ WK+ ++L P+F+ +K ++ LV+ R + + + + Sbjct: 113 SWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWER-LNADEHIEVPEDMTR 171 Query: 179 YSMDVITSTSFGVNIDSLNNPQ-DPFV--------ENTKKLLRFDFLDPFFLSITVFPFL 229 ++D I F +S Q PF+ E KL R + DP + Sbjct: 172 LTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDE------- 224 Query: 230 IPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKA 289 N F ++ + V ++ R + + + D L M+ N K+ E+ + Sbjct: 225 -------NKRQFQEDI-KVMNDLVDKIIADR-KASGEQSDDLLTHML---NGKDPETGEP 272 Query: 290 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 349 L D + Q I F+ AG+ETTS +LSF +Y L +P V QK EE VL + P+Y Sbjct: 273 LDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPV-PSYKQ 331 Query: 350 VLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMF-IPKGVVVMIPSYALHRDPKYW 408 V Q++Y+ MV+NE LRL+P A K+D + G + + KG +M+ LHRD W Sbjct: 332 VKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIW 391 Query: 409 TEP-EKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467 + E+F PERF +N I + + PFG+G R CIG +FAL L L +L++F F+ Sbjct: 392 GDDVEEFRPERF--ENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFED 449 Query: 468 CKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSG 502 ++ +K +L L+PE V+K +S+ + G Sbjct: 450 HTNYELDIKETL--TLKPEG-FVVKAKSKKIPLGG 481 >5YLW-A nrPDB Length = 495 Score = 132 bits (333), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 108/452 (23%), Positives = 198/452 (43%), Gaps = 44/452 (9%) Query: 39 PGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKEC 98 PGP P P +GN+L + K+YG + + G + ++ P+M K +L + Sbjct: 30 PGPFPYPIVGNMLQLGANPHQVFAKLSKRYGPLMSIHLGSLYTVIVSSPEMAKEILHRHG 89 Query: 99 YSVFTNRRPFGPV----------GFMKSAISIAEDEEWKRLRSLLSPT-FTSGKLKEMVP 147 VF+ R V GF+ A EW+ +R + F++ ++ Sbjct: 90 -QVFSGRTIAQAVHACDHDKISMGFLPVA------SEWRDMRKICKEQMFSNQSMEASQG 142 Query: 148 IIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENT 207 + Q L+ ++++ +++G+ V +++ +++++++T F + + Sbjct: 143 LRRQKLQQLLDHVQKCSDSGRAVDIREAAFITTLNLMSATLFSSQATEFD---------S 193 Query: 208 KKLLRFDFLDPFFLSITVFPFL---IPILEVLNICVFPREVTNFLRKSV--------KRM 256 K + F + +I P PIL + R F K + +R+ Sbjct: 194 KATMEFKEIIEGVATIVGVPNFADYFPILRPFDPQGVKRRADVFFGKLLAKIEGYLNERL 253 Query: 257 KESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSF 316 + R + DFL++++D + E + L + G +T ++ + + Sbjct: 254 ESKRANPNAPKKDDFLEIVVDIIQANEFK----LKTHHFTHLMLDLFVGGSDTNTTSIEW 309 Query: 317 IMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLER 375 M EL +PD +L+ E+ +V ++ + ++ YL V+ E +R+ P + L R Sbjct: 310 AMSELVMNPDKMARLKAELKSVAGDEKIVDESAMPKLPYLQAVIKEVMRIHPPGPLLLPR 369 Query: 376 VCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKD-NIDPYIYTP 434 + D E+NG IPKG ++I +YA+ RDP WT+PE F PERF D Y P Sbjct: 370 KAESDQEVNGYLIPKGTQILINAYAIGRDPSIWTDPETFDPERFLDNKIDFKGQDYELLP 429 Query: 435 FGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 466 FGSG R C GM A + +A ++ NF +K Sbjct: 430 FGSGRRVCPGMPLATRILHMATATLVHNFDWK 461 >3K9V-A nrPDB Length = 482 Score = 128 bits (321), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 117/448 (26%), Positives = 202/448 (45%), Gaps = 44/448 (9%) Query: 38 IPGPTPLPFLGNILS-YHKGFCMFD----MECHKKYGKVWGFYDGQQPVLAITDPDMIKT 92 +PGPT P LG++L + KG E HKKYG+++ G + + P +++ Sbjct: 26 LPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEA 85 Query: 93 VLVKECYSVFTNRRPFGPVGFMKS------AISIAEDEEWKRLRSLLSPTFTSGKLKEMV 146 + E S R P + + I E +EW+R+RS K E++ Sbjct: 86 LYRTE--SAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLM--KPVEIM 141 Query: 147 PIIAQYGDVLVRNLRREAE----TGKPVTLKDVFGAYSMD----VITSTSFGVNIDSLNN 198 + + +VL L R E G+ L +S + V+ FG+ Sbjct: 142 KLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEE 201 Query: 199 PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNF--LRKSVKRM 256 F+ K ++ F + V P + + + LN V+ + + KSVK Sbjct: 202 EALTFITAIKTMM------STFGKMMVTP--VELHKRLNTKVWQAHTLAWDTIFKSVKPC 253 Query: 257 KESRLED-TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315 ++RL+ +Q+ DFL + + + E + A+++L+L A ETT++ L Sbjct: 254 IDNRLQRYSQQPGADFLCDIYQQDHLSKKELYAAVTELQL---------AAVETTANSLM 304 Query: 316 FIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLER 375 +I+Y L+ +P Q++L +E+ +VLP+ P + + M YL + E++RL P R Sbjct: 305 WILYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTR 364 Query: 376 VCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPF 435 K + +PKG V+ + + L + + KF PER+ +K K I+P+ + PF Sbjct: 365 TLDKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEK-KINPFAHLPF 423 Query: 436 GSGPRNCIGMRFALMNMKLALIRVLQNF 463 G G R CIG R A + + LAL ++Q + Sbjct: 424 GIGKRMCIGRRLAELQLHLALCWIIQKY 451 >5W0C-A nrPDB Length = 477 Score = 126 bits (316), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 129/456 (28%), Positives = 198/456 (43%), Gaps = 55/456 (12%) Query: 39 PGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 97 PGPTPLP +GNIL K K YG V+ Y G +P++ + + +K L+ + Sbjct: 14 PGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALI-D 72 Query: 98 CYSVFTNRR--PFGPVGFMKSAISIAEDEEWKRLR--SLLS-PTFTSGKLKEMVPIIAQY 152 F+ R P I + ++WK +R SL++ F GK + + + + Sbjct: 73 LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK-RSIEDRVQEE 131 Query: 153 GDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR 212 LV LR+ + P + G +VI S F R Sbjct: 132 ARCLVEELRKTKAS--PCDPTFILGCAPCNVICSIIFHK--------------------R 169 Query: 213 FDFLDPFFLSI------TVFPFLIPILEVLN-----ICVFPREVTNFLRKSVKRMKESRL 261 FD+ D FL++ + P +++ N I FP N L K+V MK L Sbjct: 170 FDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPG-THNKLLKNVAFMKSYIL 228 Query: 262 EDTQKHR----VDFLQLMIDSQNSK-ETESHKALSD--LELVAQSIIFIF-AGYETTSSV 313 E ++H+ ++ Q ID K E E H S+ +E + + + +F AG ETTS+ Sbjct: 229 EKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTT 288 Query: 314 LSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLR---LFPIA 370 L + + L HP+V K+QEEI+ V+ P M Y D VV+E R L P + Sbjct: 289 LRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTS 348 Query: 371 MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 430 + C D++ IPKG ++I ++ D K + PE F P F + + Sbjct: 349 LPHAVTC--DIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSK 406 Query: 431 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 466 + PF +G R C+G A M + L L +LQNF+ K Sbjct: 407 YFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLK 442 >3DL9-A nrPDB Length = 479 Score = 121 bits (303), Expect = 8e-28, Method: Compositional matrix adjust. Identities = 78/253 (30%), Positives = 124/253 (49%), Gaps = 5/253 (1%) Query: 245 VTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIF 304 V +FL + +++ +R +H VD +D + + + S L+ I Sbjct: 227 VYDFLSRLIEKASVNRKPQLPQHFVD---AYLDEMDQGKNDPSSTFSKENLIFSVGELII 283 Query: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETL 364 AG ETT++VL + + +A +P++Q ++Q+EID ++ P++D +M Y + V++E L Sbjct: 284 AGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVL 343 Query: 365 RLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKN 423 R I + + +D + G IPKG V+ Y++H D KYW +PE F PERF + Sbjct: 344 RFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSS 403 Query: 424 KDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLL 483 PF G R+C+G A M M L +LQ F E LK LG L Sbjct: 404 GYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTL 463 Query: 484 QPEKPVVLKVESR 496 QP+ P ++ E R Sbjct: 464 QPQ-PYLICAERR 475 >2PG7-A nrPDB Length = 476 Score = 121 bits (303), Expect = 8e-28, Method: Compositional matrix adjust. Identities = 120/461 (26%), Positives = 196/461 (42%), Gaps = 59/461 (12%) Query: 39 PGPTPLPFLGNILSYHKGFCMFD--MECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVK 96 PGPTPLPF+GN L + M++ M+ ++YG V+ + G + V+ + D ++ LV Sbjct: 13 PGPTPLPFIGNYLQLNTE-QMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVD 71 Query: 97 EC--YSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPT---FTSGKLKEMVPIIAQ 151 + +S + F V F + + E K+LR T F GK + + I + Sbjct: 72 QAEEFSGRGEQATFDWV-FKGYGVVFSNGERAKQLRRFSIATLRDFGVGK-RGIEERIQE 129 Query: 152 YGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLL 211 L+ LR G + +VI+S FG Sbjct: 130 EAGFLIDALR--GTGGANIDPTFFLSRTVSNVISSIVFGD-------------------- 167 Query: 212 RFDFLDPFFLSI-----TVFPFLIP--------ILEVLNICVFPRE--------VTNFLR 250 RFD+ D FLS+ +F F V+ P++ + +F+ Sbjct: 168 RFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIA 227 Query: 251 KSVKRMKESRLEDTQKHRVD-FLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYET 309 K V+ + + ++ + +D FL M + + + TE + LV ++ G ET Sbjct: 228 KKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLK----NLVMTTLQLFVGGTET 283 Query: 310 TSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP- 368 S+ L + L HP+V+ K+ EEID V+ P ++ +M Y++ V++E R Sbjct: 284 VSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDV 343 Query: 369 IAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID 428 I M L R KKD + F+PKG V ++ RDP +++ P+ F P+ F + Sbjct: 344 IPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKK 403 Query: 429 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCK 469 + PF G RNC G A M + L V+QNF K + Sbjct: 404 SDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQ 444 >5UYS-A nrPDB Length = 494 Score = 120 bits (301), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 125/459 (27%), Positives = 205/459 (44%), Gaps = 36/459 (7%) Query: 36 LGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLV 95 L +P LPFL H F + KKYG ++ G + + + + K VL+ Sbjct: 14 LSLPLVGSLPFLPRHGHMHNNF----FKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLI 69 Query: 96 KECYSVFTNRRPFGPVGFM---KSAISIAED-EEWKRLRSLLSPTFTSGKL--KEMVPII 149 K+ F+ R + + I+ A+ W+ R L TF K +++ II Sbjct: 70 KKGKD-FSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKII 128 Query: 150 AQYGDVLVRNLRREAETGKPVTLK-DVFGAYSMDVITSTSFGVN-------IDSLNNPQD 201 Q L L G+ + + VF A + +VI+ F + ++ + N + Sbjct: 129 CQEISTLCDML--ATHNGQSIDISFPVFVAVT-NVISLICFNTSYKNGDPELNVIQNYNE 185 Query: 202 PFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRL 261 ++N K D L + +FP LE L V R + L K ++ KE Sbjct: 186 GIIDNLSK----DSLVDLVPWLKIFPN--KTLEKLKSHVKIR--NDLLNKILENYKEKFR 237 Query: 262 EDTQKHRVDFL---QLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIM 318 D+ + +D L ++ D+ N+ + + LSD ++ AG ETT+SV+ + + Sbjct: 238 SDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTL 297 Query: 319 YELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVC 377 L +P V++KL EEID + PT ++ L+ + E LRL P+A M + Sbjct: 298 AFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKA 357 Query: 378 KKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF-SKKNKDNIDPYI-YTPF 435 D I + KG V+I +ALH + K W +P++F+PERF + I P + Y PF Sbjct: 358 NVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPF 417 Query: 436 GSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474 G+GPR+CIG A + L + +LQ F + + Q+P Sbjct: 418 GAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLP 456 >5E58-A nrPDB Length = 493 Score = 119 bits (299), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 116/433 (26%), Positives = 189/433 (43%), Gaps = 48/433 (11%) Query: 56 GFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK 115 GF M +KYG V+ + G +PV+ + + I+ LV + F+ R G + +K Sbjct: 50 GFLNSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQA-EAFSGR---GTIAVIK 105 Query: 116 SAIS-----IAEDEEWKRLRSLLSPT---FTSGKLKEMVPIIAQYGDVLVRNLRREAETG 167 I + E WK LR T F GK + + I + LV L++ G Sbjct: 106 PVIGDYGMIFSNGERWKVLRRFSLATMRDFGMGK-RSVEDRIQEEAQCLVEELQKSQ--G 162 Query: 168 KPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFP 227 P+ +F + ++I S FG D + ++ LR LD F+ + ++ Sbjct: 163 APLDPTFLFQCITANIICSIVFGERYDYKD----------RQFLRL--LDLFYRTFSLMS 210 Query: 228 -FLIPILEVLN--ICVFP---REVTNFLRKSVKRMKESRLEDTQKHRV--------DFLQ 273 F + E+ + + FP R++T L++ + + +S +KHR DF+ Sbjct: 211 SFSSQVFELFSGFMKYFPGAHRQITRNLQEILDYVGQS----VEKHRATLDPSNPRDFID 266 Query: 274 LMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQE 333 + +++ H L+ + FAG ETTS+ L + + +P V +K+Q+ Sbjct: 267 TYLLRMEKEKSNQHTEFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQK 326 Query: 334 EIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGV 392 EID V+ + PT + +M Y D V++E R +A + KD G +PK Sbjct: 327 EIDQVIGSHRLPTLEDRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNT 386 Query: 393 VVM-IPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMN 451 V I S ALH DP+Y+ +P F P+ F N + PF G R C+G A Sbjct: 387 EVYPILSSALH-DPQYFEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNE 445 Query: 452 MKLALIRVLQNFS 464 + L +LQNFS Sbjct: 446 LFLFFTTILQNFS 458 >2NNH-A nrPDB Length = 476 Score = 119 bits (299), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 118/443 (26%), Positives = 184/443 (41%), Gaps = 29/443 (6%) Query: 39 PGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 97 PGPTPLP +GN+L K C K YG V+ Y G P++ + +K L+ Sbjct: 13 PGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDN 72 Query: 98 CYSVFTNR--RPFGPVGFMKSAISIAEDEEWKRLRSLLSPT---FTSGKLKEMVPIIAQY 152 F+ R P I + + WK +R T F GK + + + + Sbjct: 73 GEE-FSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGK-RSIEDRVQEE 130 Query: 153 GDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR 212 LV LR+ + P + G +VI S F D + ++ + R Sbjct: 131 AHCLVEELRKTKAS--PCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFR 188 Query: 213 FDFLDPFFLSITVFPFLIPIL-----EVLNICVFPREVTNFLRKSVKRMKESRLEDTQKH 267 P+ FP LI +VL R +++R+ VK + S + + Sbjct: 189 I-LNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTR---SYIREKVKEHQASLDVNNPRD 244 Query: 268 RVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIF-AGYETTSSVLSFIMYELATHPD 326 +D + ++ +E ++ K+ ++E + ++ +F AG ETTS+ L + + L HP+ Sbjct: 245 FIDCFLIKME----QEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPE 300 Query: 327 VQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLR---LFPIAMRLERVCKKDVEI 383 V K+QEEID V+ P M Y D VV+E R L P + D + Sbjct: 301 VTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTG--VPHAVTTDTKF 358 Query: 384 NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCI 443 IPKG +M ++ D K + P F P F KN + + PF +G R C Sbjct: 359 RNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICA 418 Query: 444 GMRFALMNMKLALIRVLQNFSFK 466 G A M + L L +LQNF+ K Sbjct: 419 GEGLARMELFLFLTTILQNFNLK 441 >4GQS-A nrPDB Length = 477 Score = 119 bits (297), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 118/445 (26%), Positives = 186/445 (41%), Gaps = 33/445 (7%) Query: 39 PGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 97 PGPTPLP +GNIL K K YG V+ Y G + ++ + +++K L+ + Sbjct: 14 PGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALI-D 72 Query: 98 CYSVFTNRR--PFGPVGFMKSAISIAEDEEWKRLR--SLLS-PTFTSGKLKEMVPIIAQY 152 F+ R P I + + WK +R SL++ F GK + + + + Sbjct: 73 LGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK-RSIEDRVQEE 131 Query: 153 GDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR 212 LV LR+ + P + G +VI S F D + +E + +R Sbjct: 132 ARCLVEELRKTKAS--PCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIR 189 Query: 213 FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHR---- 268 P+ FP +I FP N L K++ M+ LE ++H+ Sbjct: 190 I-VSTPWIQICNNFPTIID--------YFP-GTHNKLLKNLAFMESDILEKVKEHQESMD 239 Query: 269 ----VDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324 DF+ + ++ + LV + + AG ETTS+ L + + L H Sbjct: 240 INNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKH 299 Query: 325 PDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLR---LFPIAMRLERVCKKDV 381 P+V K+QEEI+ V+ P M Y D VV+E R L P ++ C DV Sbjct: 300 PEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTC--DV 357 Query: 382 EINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441 + IPKG ++ ++ D K + PE F P F + + + PF +G R Sbjct: 358 KFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRI 417 Query: 442 CIGMRFALMNMKLALIRVLQNFSFK 466 C+G A M + L L +LQNF+ K Sbjct: 418 CVGEGLARMELFLFLTFILQNFNLK 442 >1N6B-A nrPDB Length = 473 Score = 114 bits (285), Expect = 9e-26, Method: Compositional matrix adjust. Identities = 116/444 (26%), Positives = 192/444 (43%), Gaps = 34/444 (7%) Query: 39 PGPTPLPFLGNILSY-----HKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTV 93 PGPTP P +GNIL K F EC YG V+ Y G +P + + + +K Sbjct: 13 PGPTPFPIIGNILQIDAKDISKSLTKFS-EC---YGPVFTVYLGMKPTVVLHGYEAVKEA 68 Query: 94 LVKECYSVFTNRRPFGPVGFMKS-----AISIAEDEEWKRLR--SLLS-PTFTSGKLKEM 145 LV + F R G V ++ I+ + + WK +R SL++ F GK + + Sbjct: 69 LV-DLGEEFAGR---GSVPILEKVSKGLGIAFSNAKTWKEMRRFSLMTLRNFGMGK-RSI 123 Query: 146 VPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVE 205 I + LV LR+ P + G +VI S F D + +E Sbjct: 124 EDRIQEEARCLVEELRKT--NASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKLME 181 Query: 206 NTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPRE--VTNFLRKSVKRMKESRLED 263 + + + P+ FP L+ ++ + + NF+ + VK ++ + Sbjct: 182 SLHENVEL-LGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLLDVN 240 Query: 264 TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELAT 323 + +D + ++ +N+ E L L ++A S +F AG ETTS+ L + + L Sbjct: 241 NPRDFIDCFLIKMEQENNLEF----TLESL-VIAVSDLF-GAGTETTSTTLRYSLLLLLK 294 Query: 324 HPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPI-AMRLERVCKKDVE 382 HP+V ++QEEI+ V+ P +M Y D V++E R + L +DV Sbjct: 295 HPEVAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVR 354 Query: 383 INGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNC 442 FIPKG ++ ++ D K + P+ F P F ++ + + PF +G R C Sbjct: 355 FRNYFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRMC 414 Query: 443 IGMRFALMNMKLALIRVLQNFSFK 466 +G A M + L L +LQNF + Sbjct: 415 VGEGLARMELFLFLTSILQNFKLQ 438 >4R1Z-A nrPDB Length = 439 Score = 113 bits (283), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 86/287 (29%), Positives = 146/287 (50%), Gaps = 20/287 (6%) Query: 223 ITVFPFLIPI----LEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDS 278 + +FP+L L +L C+ R+ L+K + K + ++ Q+ D L ++ + Sbjct: 148 VDIFPWLQIFPNKDLTILRQCISIRD--KLLQKKYEEHKVTYSDNVQR---DLLDALLRA 202 Query: 279 QNSKETESHKALSDLELVAQSIIF----IF-AGYETTSSVLSFIMYELATHPDVQQKLQE 333 + S E ++ + D+ L ++ IF AG ETT++VL + + L +P VQ+K+QE Sbjct: 203 KRSSEN-NNSSTRDVGLTEDHVLMTVGDIFGAGVETTTTVLKWSIAYLVHNPQVQRKIQE 261 Query: 334 EIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGV 392 E+D+ + + P + YL+ + E LR+ P++ + + V +D + + KG Sbjct: 262 ELDSKIGKERHPQLSDRGNLPYLEATIREVLRIRPVSPLLIPHVALQDSSVGEYTVQKGT 321 Query: 393 VVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNI--DPYIYTPFGSGPRNCIGMRFALM 450 V+I ++LH D K W PE F P RF + D + Y PFG+G R C+G A M Sbjct: 322 RVVINLWSLHHDKKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKM 381 Query: 451 NMKLALIRVLQNFSFK-PCKETQIPLKLSLGGLLQPEK-PVVLKVES 495 + L L +LQ F+ + P + L+ G +LQP+K VV KV + Sbjct: 382 ELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPKKFKVVAKVRA 428 >5VBU-A nrPDB Length = 476 Score = 113 bits (282), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 103/417 (24%), Positives = 187/417 (44%), Gaps = 23/417 (5%) Query: 66 KKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRP--FGPVGFMKSAISIAE- 122 +K+G ++ + G Q V+ + I+ +VK+ P + V +S+ + Sbjct: 35 QKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDY 94 Query: 123 DEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMD 182 WK + L G M P++ Q +R A+ G PV +++ F + Sbjct: 95 SLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMR--AQPGTPVAIEEEFSLLTCS 152 Query: 183 VITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLI----PILEVLNI 238 +I +FG I +N + + +++L+ + + V PFL P L L Sbjct: 153 IICYLTFGDKIKD-DNLMPAYYKCIQEVLK-TWSHWSIQIVDVIPFLRFFPNPGLRRLKQ 210 Query: 239 CVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQ 298 + R+ + + +++ KES + + +D++ L +Q S E S + L +A Sbjct: 211 AIEKRD--HIVEMQLRQHKESLVAGQWRDMMDYM-LQGVAQPSMEEGSGQLLEGHVHMA- 266 Query: 299 SIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT---YDTVLQMEY 355 ++ + G ETT++ LS+ + L HP++QQ+LQEE+D L A + Y ++ Sbjct: 267 AVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPL 326 Query: 356 LDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKF 414 L+ + E LRL P+ + L + I+G IP+G V++ H D W P +F Sbjct: 327 LNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEF 386 Query: 415 LPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET 471 P+RF + K++ FG G R C+G A + + + L R+LQ F+ P + Sbjct: 387 WPDRFLEPGKNS----RALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDA 439 >6B82-A nrPDB Length = 509 Score = 113 bits (282), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 117/480 (24%), Positives = 213/480 (44%), Gaps = 36/480 (7%) Query: 39 PGPTPLPFLGNILSYHKGF--CMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVK 96 P LP +G+++S +F + KKYG ++ G +L + + K +L+K Sbjct: 26 PSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNNHHHAKEILIK 85 Query: 97 ECYSVFTNR-RPFGPVGFMKSAISIA---EDEEWKRLRSLLSPT---FTSGKLKEMVPII 149 + +F R R + IA WK R ++ F G + + II Sbjct: 86 KG-KIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKMVHGALCMFGEGSV-SIEKII 143 Query: 150 AQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKK 209 + + L + V L +V+ + F + + + ++ ++ Sbjct: 144 CREASSMCEVLTESQNSA--VDLGPELTRAVTNVVCALCFNSSYKRGDAEFESMLQYSQG 201 Query: 210 LLRFDFLDPFFLSITVFPFLIPI----LEVLNICVFPREVTNFLRKSVKRMKESRLEDTQ 265 ++ D + +FP+L L +L C+ R+ L+K + K + ++ Q Sbjct: 202 IVDTVAKDSL---VDIFPWLQIFPNKDLRILRQCISIRD--KLLQKKYEEHKVTYSDNVQ 256 Query: 266 KHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIF----IF-AGYETTSSVLSFIMYE 320 + D L ++ ++ S E ++ + D+ L ++ IF AG ETT++ L + + Sbjct: 257 R---DLLDALLRAKRSSEN-NNSSTRDVGLTEDHVLMTVGEIFGAGVETTTTTLKWSIAY 312 Query: 321 LATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKK 379 L +P VQ+K+QEE+D+ + + P + YL+ + E +R+ P++ + + V + Sbjct: 313 LVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSPLLIPHVALQ 372 Query: 380 DVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNI--DPYIYTPFGS 437 D + + KG V+I ++LH D K W PE F P RF + D + Y PFG+ Sbjct: 373 DSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGA 432 Query: 438 GPRNCIGMRFALMNMKLALIRVLQNFSFK-PCKETQIPLKLSLGGLLQPEK-PVVLKVES 495 G R C+G A M + L L +LQ F+ + P + L+ G +LQP+K VV KV + Sbjct: 433 GVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPKKFKVVAKVRA 492 >2VE3-A nrPDB Length = 444 Score = 112 bits (280), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 63/186 (33%), Positives = 102/186 (54%), Gaps = 2/186 (1%) Query: 281 SKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLP 340 + ++++ LS EL Q ++ +FAG+ET +S LS L H D+++++++E + + Sbjct: 230 AARDDNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQEQNKLQL 289 Query: 341 NKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYA 400 ++ T +T+ +M YLD V+ E LRL P R +D + G PKG +V Sbjct: 290 SQEL-TAETLKKMPYLDQVLQEVLRLIPPVGGGFRELIQDCQFQGFHFPKGWLVSYQISQ 348 Query: 401 LHRDPKYWTEPEKFLPERFSKKNKDNIDP-YIYTPFGSGPRNCIGMRFALMNMKLALIRV 459 H DP + +PEKF PERF+ +P + + PFG G R C+G FA + MKL R+ Sbjct: 349 THADPDLYPDPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECLGKEFARLEMKLFATRL 408 Query: 460 LQNFSF 465 +Q F + Sbjct: 409 IQQFDW 414 >3QZ1-A nrPDB Length = 496 Score = 111 bits (278), Expect = 7e-25, Method: Compositional matrix adjust. Identities = 93/351 (26%), Positives = 152/351 (43%), Gaps = 24/351 (6%) Query: 126 WKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVIT 185 WK + L G M P + Q +R +A G PVT++ F + +I Sbjct: 117 WKAHKKLTRSALLLGTRSSMEPWVDQLTQEFCERMRVQA--GAPVTIQKEFSLLTCSIIC 174 Query: 186 STSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREV 245 +FG D+L + V++ K +D L + F P + + Sbjct: 175 YLTFGNKEDTLVHAFHDCVQDLMKT--WDHWSIQILDMVPFLRFFPNPGLWRLKQAIENR 232 Query: 246 TNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKET-----ESHKALSDLELVAQSI 300 + + K ++R KES + + D++ + Q +E E H +S ++L Sbjct: 233 DHMVEKQLRRHKESMVAGQWRDMTDYMLQGVGRQRVEEGPGQLLEGHVHMSVVDL----- 287 Query: 301 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPP---TYDTVLQMEYLD 357 G ETT+S LS+ + L HP++Q++LQEE+D L A TY ++ L+ Sbjct: 288 --FIGGTETTASTLSWAVAFLLHHPEIQRRLQEELDRELGPGASCSRVTYKDRARLPLLN 345 Query: 358 MVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLP 416 + E LRL P+ + L + I G IP+G+VV+ H D W +P +F P Sbjct: 346 ATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGMVVIPNLQGAHLDETVWEQPHEFRP 405 Query: 417 ERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467 +RF + +P FG G R C+G A + + + L R+LQ F+ P Sbjct: 406 DRFLEPGA---NPSALA-FGCGARVCLGESLARLELFVVLARLLQAFTLLP 452 >5E0E-A nrPDB Length = 463 Score = 111 bits (277), Expect = 9e-25, Method: Compositional matrix adjust. Identities = 114/440 (25%), Positives = 181/440 (41%), Gaps = 62/440 (14%) Query: 56 GFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVG--F 113 GF +KYG V+ + G +PV+ + + I+ LV + F+ R V F Sbjct: 22 GFLNSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQA-EAFSGRGTIAVVEPIF 80 Query: 114 MKSAISIAEDEEWKRLRSLLSPT---FTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPV 170 + A E WK LR T F GK + + I + LV R+ G P+ Sbjct: 81 RGYGVVFANGERWKALRRFSLVTMRDFGMGK-RSVEERIQEEARCLVEEFRKSQ--GAPL 137 Query: 171 TLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPF-- 228 +F + ++I S FG RFD+ D FL + + Sbjct: 138 DPTFLFQCITANIICSIVFGE--------------------RFDYKDHQFLRLLYLFYQS 177 Query: 229 -------LIPILEVLN--ICVFP---REVTNFLRKSVKRMKESRLEDTQKHRV------- 269 + E+ + + FP R+++ L++ + + +S +KHR Sbjct: 178 FSLISSFSSQVFELFSGFLKYFPGTHRQISRNLQEILDYIGQS----VEKHRATLDPSHP 233 Query: 270 -DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQ 328 DF+ + +++ H LV + FAG ET+S+ L + + +P V Sbjct: 234 RDFIDTYLLRMEKEKSNQHTEFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVA 293 Query: 329 QKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLR---LFPIAMRLERVCKKDVEING 385 +K+Q+EID V+ + PT + +M Y + V+ E R L PI + KD G Sbjct: 294 EKVQKEIDQVIGSHRLPTLEDRTKMPYTEAVIYEIQRFSDLIPIG--VPHKVTKDTLFRG 351 Query: 386 MFIPKGVVVM-IPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIG 444 +PK V I S ALH DP+Y+ +P+ F P+ F N + PF G R C+G Sbjct: 352 YLLPKNTEVYPILSSALH-DPQYFEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLG 410 Query: 445 MRFALMNMKLALIRVLQNFS 464 A + L +LQNFS Sbjct: 411 EGIARNELFLFFTTILQNFS 430 >3E6I-A nrPDB Length = 476 Score = 110 bits (275), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 116/448 (25%), Positives = 190/448 (42%), Gaps = 38/448 (8%) Query: 39 PGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLV-- 95 PGP PLP +GN+ K +++G V+ Y G Q ++ + +K L+ Sbjct: 13 PGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDY 72 Query: 96 KECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEM--VPIIAQYG 153 K+ +S + F I WK +R T + + + I + Sbjct: 73 KDEFSGRGDLPAFH--AHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREA 130 Query: 154 DVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRF 213 L+ LR+ G+P + G +VI F + D N +K LR Sbjct: 131 HFLLEALRKTQ--GQPFDPTFLIGCAPCNVIADILFRKHFDY----------NDEKFLRL 178 Query: 214 DFL---------DPFFLSITVFPFLIPILEVLNICVFPR--EVTNFLRKSVKRMKESRLE 262 +L P+ FP + L + V EV ++ + VK +S Sbjct: 179 MYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDP 238 Query: 263 DTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSII-FIFAGYETTSSVLSFIMYEL 321 + + D L + ++ KE S + L ++ + ++ FAG ETTS+ L + + L Sbjct: 239 NCPRDLTDCLLVEME----KEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLIL 294 Query: 322 ATHPDVQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDMVVNETLRLFP-IAMRLERVCKK 379 +P++++KL EEID V+ P++ P D +M Y+D VV+E R + L + Sbjct: 295 MKYPEIEEKLHEEIDRVIGPSRIPAIKDRQ-EMPYMDAVVHEIQRFITLVPSNLPHEATR 353 Query: 380 DVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGP 439 D G IPKG VV+ ++ D + + +PEKF PE F +N + PF +G Sbjct: 354 DTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGK 413 Query: 440 RNCIGMRFALMNMKLALIRVLQNFSFKP 467 R C G A M + L L +LQ+F+ KP Sbjct: 414 RVCAGEGLARMELFLLLCAILQHFNLKP 441 >3JUS-A nrPDB Length = 461 Score = 105 bits (263), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 103/433 (23%), Positives = 183/433 (42%), Gaps = 35/433 (8%) Query: 42 TPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVL------- 94 +P+PFLG+ +++ K F ++KYG V+ F + + D + Sbjct: 18 SPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDL 77 Query: 95 -VKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYG 153 ++ YS T PV F K + + + +L K+ V II + Sbjct: 78 NAEDVYSRLTT-----PV-FGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKET 131 Query: 154 DVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRF 213 + E+G+ K+VF A S +I + S ++ + + + V L Sbjct: 132 KEYFESW---GESGE----KNVFEALSELIILTASHCLHGKEIRSQLNEKVAQ----LYA 180 Query: 214 DFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQ 273 D F + + P +P+ RE+ + K++++ ++S Q+ D LQ Sbjct: 181 DLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQS-----QEKIDDILQ 235 Query: 274 LMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQE 333 ++D+ + + L+D E+ I + AG T+S+ +++ + LA +Q+K Sbjct: 236 TLLDAT----YKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYL 291 Query: 334 EIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGV 392 E V PP TYD + + LD + ETLRL P M + R+ + + G IP G Sbjct: 292 EQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGH 351 Query: 393 VVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNM 452 V + R W E F P+R+ + N + + + Y PFG+G CIG FA + + Sbjct: 352 QVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQI 411 Query: 453 KLALIRVLQNFSF 465 K +L+ + F Sbjct: 412 KTIWSTMLRLYEF 424 >3IBD-A nrPDB Length = 476 Score = 105 bits (262), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 107/416 (25%), Positives = 176/416 (42%), Gaps = 34/416 (8%) Query: 66 KKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVG--FMKSAISIAED 123 +KYG V+ + G +PV+ + + I+ LV + F+ R V F + A Sbjct: 41 EKYGDVFTVHLGPRPVVMLCGVEAIREALVDKA-EAFSGRGKIAMVDPFFRGYGVIFANG 99 Query: 124 EEWKRLRSLLSPT---FTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS 180 WK LR T F GK + + I + L+ LR+ G + +F + + Sbjct: 100 NRWKVLRRFSVTTMRDFGMGK-RSVEERIQEEAQCLIEELRKSK--GALMDPTFLFQSIT 156 Query: 181 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV 240 ++I S FG + QD + K+L F F L +VF L + + Sbjct: 157 ANIICSIVFGKRF----HYQD---QEFLKMLNL-FYQTFSLISSVFGQLFELFSGF-LKH 207 Query: 241 FP----------REVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKAL 290 FP +E+ ++ SV++ +E+ + +D L ++ + S +H Sbjct: 208 FPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSN---AHSEF 264 Query: 291 SDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTV 350 S L ++ FAG ETTS+ L + + +P V +++ EI+ V+ PP Sbjct: 265 SHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDR 324 Query: 351 LQMEYLDMVVNETLRLFPI-AMRLERVCKKDVEINGMFIPKGV-VVMIPSYALHRDPKYW 408 +M Y + V+ E R + M + + + G IPK V +I S ALH DP Y+ Sbjct: 325 AKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALH-DPHYF 383 Query: 409 TEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS 464 +P+ F P+ F N + PF G R C+G A + L +LQNFS Sbjct: 384 EKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS 439 >3MZS-A nrPDB Length = 486 Score = 103 bits (258), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 71/201 (35%), Positives = 109/201 (54%), Gaps = 6/201 (2%) Query: 293 LELVAQSIIFIFAG-YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL 351 LE V +I + AG TTS L + +YE+A +VQ+ L+EE+ +A +L Sbjct: 274 LEDVKANITEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNAR-RQAEGDISKML 332 Query: 352 QM-EYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTE 410 QM L + ETLRL PI++ L+R + D+ + IP +V + YA+ RDP +++ Sbjct: 333 QMVPLLKASIKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSS 392 Query: 411 PEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKE 470 P+KF P R+ K+KD I + FG G R C+G R A + M L LI +L+NF + Sbjct: 393 PDKFDPTRWLSKDKDLIH-FRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHI 451 Query: 471 TQIPLKLSLGGLLQPEKPVVL 491 + +L +L P+KP+ L Sbjct: 452 GDVDTIFNL--ILTPDKPIFL 470 >3N9Z-A nrPDB Length = 487 Score = 101 bits (251), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 65/186 (34%), Positives = 102/186 (54%), Gaps = 5/186 (2%) Query: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQM-EYLDMVVNET 363 G +TTS L + +YE+A + VQ L+ E+ A ++A T+LQ+ L + ET Sbjct: 286 GGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAAR-HQAQGDMATMLQLVPLLKASIKET 344 Query: 364 LRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKN 423 LRL PI++ L+R D+ + IP +V + YAL R+P ++ +PE F P R+ K+ Sbjct: 345 LRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKD 404 Query: 424 KDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLL 483 K NI + FG G R C+G R A + M + LI +L+NF + + + +L +L Sbjct: 405 K-NITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNL--IL 461 Query: 484 QPEKPV 489 PEKP+ Sbjct: 462 MPEKPI 467 >2HI4-A nrPDB Length = 495 Score = 101 bits (251), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 109/459 (23%), Positives = 188/459 (40%), Gaps = 52/459 (11%) Query: 39 PGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE- 97 P P P LG++L+ K + ++YG V G PVL ++ D I+ LV++ Sbjct: 19 PEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQG 78 Query: 98 ----------CYSVFTNRRPF------GPVGFMK--------SAISIAEDEEWKRLRSLL 133 ++ T+ + GPV + + SIA D S Sbjct: 79 DDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPA-----SSS 133 Query: 134 SPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNI 193 S KE +I++ +++ + V++ +V GA S + Sbjct: 134 SCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEML 193 Query: 194 DSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFL--IPILEVLNICVFPREVTNFLRK 251 + N + FVE DF FP L +P + F + FL+K Sbjct: 194 SLVKNTHE-FVETASSGNPLDF----------FPILRYLPNPALQRFKAFNQRFLWFLQK 242 Query: 252 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIF-AGYETT 310 +V + +D K+ V + + + K + L E + + IF AG++T Sbjct: 243 TV----QEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTV 298 Query: 311 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP-I 369 ++ +S+ + L T P++Q+K+Q+E+D V+ + P Q+ YL+ + ET R + Sbjct: 299 TTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFL 358 Query: 370 AMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP 429 + +D +NG +IPK V + + ++ DP+ W +P +F PERF + I+ Sbjct: 359 PFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINK 418 Query: 430 YIYTP---FGSGPRNCIGMRFALMNMKLALIRVLQNFSF 465 + FG G R CIG A + L L +LQ F Sbjct: 419 PLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEF 457 >2W0A-A nrPDB Length = 455 Score = 99.0 bits (245), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 68/258 (26%), Positives = 127/258 (49%), Gaps = 6/258 (2%) Query: 244 EVTNFLRKSVKRMKESRLED--TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSII 301 E N L V + R+ + T K D L ++I + ET + + +D E+ I Sbjct: 196 EARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVK--AETGTPRFSAD-EITGMFIS 252 Query: 302 FIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVN 361 +FAG+ T+S S+ + EL H D + +E+D + + ++ + Q+ L+ V+ Sbjct: 253 MMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQLENVLK 312 Query: 362 ETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421 ETLRL P + L RV K + E+ G I +G +V +R P+ + +P F+P R+ + Sbjct: 313 ETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFVPARYEQ 372 Query: 422 -KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480 + +D ++ + + PFG+G C+G FA+M +K +L+ + F+ + + Sbjct: 373 PRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQPPESYRNDHSK 432 Query: 481 GLLQPEKPVVLKVESRDG 498 ++Q +P ++ R G Sbjct: 433 MVVQLAQPAAVRYRRRTG 450 >6DWN-A nrPDB Length = 491 Score = 97.8 bits (242), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 113/461 (24%), Positives = 191/461 (41%), Gaps = 55/461 (11%) Query: 39 PGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE- 97 PGP P +G++L+ K + ++YG V G PV+ ++ D I+ LV++ Sbjct: 14 PGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQG 73 Query: 98 ----------CYSVFTNRRPF------GPVGFMK--------SAISIAEDEEWKRLRSLL 133 +++ +N + GPV + + SIA D Sbjct: 74 DDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASD---------- 123 Query: 134 SPTFTSGKLKEMVPIIAQYGDVLVRNLRR-EAETGKPVTLKDVFGAYSMDVITSTSFGVN 192 + TS L+E V ++ +VL+ L+ A G + V + + +VI + FG Sbjct: 124 PASSTSCYLEEHV---SKEAEVLISTLQELMAGPGHFNPYRYVVVSVT-NVICAICFGRR 179 Query: 193 IDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVL---NICVFPREVTNFL 249 D +N Q E + + S F IPIL L ++ F F Sbjct: 180 YD--HNHQ----ELLSLVNLNNNFGEVVGSGNPADF-IPILRYLPNPSLNAFKDLNEKFY 232 Query: 250 RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHK--ALSDLELVAQSIIFIFAGY 307 K +KE + H D +I+ K+ + + LSD +++ + AG+ Sbjct: 233 SFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGF 292 Query: 308 ETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF 367 +T ++ +S+ + L +P VQ+K+QEE+D V+ P + Y++ + ET R Sbjct: 293 DTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHS 352 Query: 368 P-IAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK-- 424 + + +D + G +IPKG V + + ++ D K W P +FLPERF + Sbjct: 353 SFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAI 412 Query: 425 DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSF 465 D + FG G R CIG A + L L +LQ F Sbjct: 413 DKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEF 453 >3TBG-A nrPDB Length = 479 Score = 97.8 bits (242), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 52/162 (32%), Positives = 84/162 (51%), Gaps = 1/162 (0%) Query: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETL 364 AG TTS+ L++ + + HPDVQ+++Q+EID V+ P M Y V++E Sbjct: 283 AGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQ 342 Query: 365 RLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKN 423 R I + + + +D+E+ G IPKG ++ ++ +D W +P +F PE F Sbjct: 343 RFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQ 402 Query: 424 KDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSF 465 + P + PF +G R C+G A M + L +LQ+FSF Sbjct: 403 GHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF 444 >6AYB-A nrPDB Length = 466 Score = 97.1 bits (240), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 105/469 (22%), Positives = 200/469 (42%), Gaps = 40/469 (8%) Query: 41 PTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVK---- 96 P +P++G+ +S+ K F ++ KKYG V+ + + + P ++ T Sbjct: 16 PNLIPYVGSFVSFAKNPVQFIIDNSKKYGDVFTATILGKEMTFLNHPKILDTFFKATDNE 75 Query: 97 -ECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDV 155 V+ RP G + A S E +S T+ + + V I Sbjct: 76 LSLRDVYRFMRPVFGTGVVYDADST---ERMMEQVKFVSSGLTTARFRVFVDIFEDEIAH 132 Query: 156 LVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDF 215 V+ L E + D+ +I + S + D + + E L D Sbjct: 133 KVKELGPEGTVDVAELMADL-------IIFTASRCLLGDEV---RQYLSEKNLGKLYHDI 182 Query: 216 LDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSV----KRMKESRLEDTQKHRVDF 271 D I+ F P L P + RK+V + + + R E+ +KH Sbjct: 183 DD----GISPLSFFYPSL--------PAPKRDKARKAVGEIFQELLDKRREEHKKHPERL 230 Query: 272 LQL----MIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDV 327 L ++D +++ + + L+D+ + I +FAG T+S S+ + + ++ V Sbjct: 231 LDESKMDVVDHLLTQKYKDGQELTDVHRIGILIAGLFAGQHTSSITSSWTLMNVISNKKV 290 Query: 328 QQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMF 387 +K+++E + ++ + YD V++M+YL+ + E LR++P + + R+ +K E Sbjct: 291 LEKVRKEQEEIMGSDKVLDYDKVMKMDYLEACMKEALRMYPPLIMIMRMARKPRECEQYI 350 Query: 388 IPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRF 447 IPKG ++++ R +T P+ F PER +++ + Y PFG+G CIG F Sbjct: 351 IPKGNILVVSPSVAGRCTDTYTNPDVFDPERLTERKEHEKFKYGAVPFGAGRHKCIGENF 410 Query: 448 ALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496 AL+ +K + +L+ F + + P SL ++ P P ++ + R Sbjct: 411 ALLQVKSIISILLRYFDMEYIGKIPDPSYTSL--VVGPSPPTRMRYKLR 457 >3EL3-A nrPDB Length = 467 Score = 92.4 bits (228), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 48/197 (24%), Positives = 100/197 (50%), Gaps = 5/197 (2%) Query: 270 DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQ 329 D L ++++++ ++ + + E+ Q + + G ET +S + +++ LA HP+ Sbjct: 243 DLLTALLEAKD----DNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHAD 298 Query: 330 KLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIP 389 ++++E++AV + P ++ V ++ + V+ E +RL P L R + E+ G IP Sbjct: 299 RIRDEVEAVTGGR-PVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIP 357 Query: 390 KGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449 G ++ YA+ RDPK + + +F P+R+ + N+ Y PF +G R C F++ Sbjct: 358 AGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSM 417 Query: 450 MNMKLALIRVLQNFSFK 466 + L + + F+ Sbjct: 418 AQLTLITAALATKYRFE 434 >6M7X-A nrPDB Length = 484 Score = 86.7 bits (213), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 50/157 (31%), Positives = 81/157 (51%), Gaps = 1/157 (0%) Query: 290 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 349 LS + A S+ +TT L ++ELA +P+VQQ L++E A + + Sbjct: 276 LSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKA 335 Query: 350 VLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWT 409 ++ L + ETLRL+P+ + LERV D+ + IP G +V + Y+L R+P + Sbjct: 336 TTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFP 395 Query: 410 EPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMR 446 PE++ P+R+ + Y + PFG G R C+G R Sbjct: 396 RPERYNPQRWLDIRGSGRNFY-HVPFGFGMRQCLGRR 431 >6IQ5-A nrPDB Length = 463 Score = 86.3 bits (212), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 104/448 (23%), Positives = 183/448 (40%), Gaps = 37/448 (8%) Query: 66 KKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIA---E 122 ++YG V+ G P++ + I LV++ S F +R F + S+A Sbjct: 12 RRYGDVFQIRLGSCPIVVLNGERAIHQALVQQG-SAFADRPSFASFRVVSGGRSMAFGHY 70 Query: 123 DEEWKRLR----SLLSPTFTSGKLKEMV---PIIAQYGDVLVRNLRREAETG----KPVT 171 E WK R S++ FT V ++++ +++ +R A+ +P+T Sbjct: 71 SEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLT 130 Query: 172 LKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLI- 230 + V +V+++ FG S ++P+ F E F + V P+L Sbjct: 131 VVAV-----ANVMSAVCFGCRY-SHDDPE--FRELLSHNEEFGRTVGAGSLVDVMPWLQY 182 Query: 231 ---PILEVLN-ICVFPREVTNFLRKSVKRMKES-RLEDTQKHRVDFLQLMIDSQNSKETE 285 P+ V R +NF+ R ES R + +D L + + + ++ Sbjct: 183 FPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSH 242 Query: 286 SHKALSDLELVAQSIIFIF-AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAP 344 A DLE V +I IF A +T S+ L +++ +PDVQ ++Q E+D V+ Sbjct: 243 GGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRL 302 Query: 345 PTYDTVLQMEYLDMVVNETLRLFP-IAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHR 403 P + Y+ + E +R + + + + + G IPK VV + ++++ Sbjct: 303 PCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNH 362 Query: 404 DPKYWTEPEKFLPERFSKK----NKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRV 459 DP W PE F P RF K NKD + F G R CIG + M + L + + Sbjct: 363 DPVKWPNPENFDPARFLDKDGLINKDLTSRVMI--FSVGKRRCIGEELSKMQLFLFISIL 420 Query: 460 LQNFSFKPCKETQIPLKLSLGGLLQPEK 487 F+ + S G ++P+ Sbjct: 421 AHQCDFRANPNEPAKMNFSYGLTIKPKS 448 >4ZGX-A nrPDB Length = 489 Score = 85.5 bits (210), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 51/160 (31%), Positives = 85/160 (53%), Gaps = 2/160 (1%) Query: 288 KALSDLELVAQSIIFIFAG-YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT 346 KA LE + + + + AG +TT+ L ++ELA +PDVQQ L++E A + + Sbjct: 273 KAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHP 332 Query: 347 YDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPK 406 ++ L + ETLRL+P+ + LERV D+ + IP G +V + Y+L R+ Sbjct: 333 QKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAA 392 Query: 407 YWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMR 446 + PE++ P+R+ + + + PFG G R C+G R Sbjct: 393 LFPRPERYNPQRWLDIRGSGRN-FHHVPFGFGMRQCLGRR 431 >6CR2-A nrPDB Length = 477 Score = 78.6 bits (192), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 105/453 (23%), Positives = 185/453 (40%), Gaps = 54/453 (11%) Query: 44 LPFLGNILSYHKGFCMFDMECHKKYGKVWGF-YDGQQPV--LAITDPDMI-----KTVLV 95 PF+G+ +SY F +C KYG ++ F G++ L D I + V Sbjct: 13 FPFIGSTISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTVYLGTKGNDFILNGKLRDVCA 72 Query: 96 KECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDV 155 +E YS T PV F + + + + + + TS L+ VP+I + Sbjct: 73 EEVYSPLTT-----PV-FGRHVVYDCPNAKLMEQKKFVKYGLTSDALRSYVPLITDEVES 126 Query: 156 LVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDP-FVENTKKLLRFD 214 V+N A G DV + I + S + + + D F E + Sbjct: 127 FVKN--SPAFQGHKGVF-DVCKTIAEITIYTASRSLQGKEVRSKFDSTFAE------LYH 177 Query: 215 FLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQL 274 LD F I P+ R++T + +K +++ ++K D + Sbjct: 178 NLDMGFAPINFMLPWAPLPHNRKRDAAQRKLTETYMEIIKARRQA---GSKKDSEDMVWN 234 Query: 275 MIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEE 334 ++ T + D E+ I + AG ++SS S+I+ LAT PD+ ++L +E Sbjct: 235 LMSCVYKNGT----PVPDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQE 290 Query: 335 IDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGM--FIPKG 391 VL + PP TYD + +++ V+ ETLRL + R K + ++G IP Sbjct: 291 QIRVLGSDLPPLTYDNLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTS 350 Query: 392 VVVMIPSYALHRDPKYWTEPEKFLPERF------SKKNKDNID------------PYIYT 433 V+ R +++ P ++ P R+ S ++ + +D PY+ Sbjct: 351 HNVLSSPGVTARSEEHFPNPLEWNPHRWDENIAASAEDDEKVDYGYGLVSKGTNSPYL-- 408 Query: 434 PFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 466 PFG+G CIG +FA + + +++ F F+ Sbjct: 409 PFGAGRHRCIGEQFAYLQLGTITAVLVRLFRFR 441 >3P3Z-A nrPDB Length = 416 Score = 78.2 bits (191), Expect = 9e-15, Method: Compositional matrix adjust. Identities = 52/168 (30%), Positives = 78/168 (46%), Gaps = 27/168 (16%) Query: 290 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 349 L D EL + AGYETT+ L+ MY+ A HPD K++E P AP Sbjct: 238 LDDYELRTLVATVLVAGYETTNHQLALAMYDFAQHPDQWMKIKEN-----PELAP----- 287 Query: 350 VLQMEYLDMVVNETLRLFP-IAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYW 408 V E LR P + + RV +D E+NG+ IP G V + ++ HRDP+ + Sbjct: 288 --------QAVEEVLRWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAHRDPRVF 339 Query: 409 TEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLAL 456 + ++F + K+ +I FG GP C+G A + + A+ Sbjct: 340 ADADRF--DITVKREAPSI------AFGGGPHFCLGTALARLELTEAV 379 >3S79-A nrPDB Length = 503 Score = 76.6 bits (187), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 103/441 (23%), Positives = 185/441 (41%), Gaps = 38/441 (8%) Query: 38 IPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWG-----FYDGQQPVLAITDPDMIKT 92 IPGP +G ++S+ + M Y +V+G + G++ ++ M Sbjct: 47 IPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHI 106 Query: 93 VLVKECYSVFTNRRPFGPVGFMKSAISIAEDEE-WKRLRSLLSPTFTSGKLKEMVPIIAQ 151 + S F ++ +G + I + E WK R + L MV + A+ Sbjct: 107 MKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAE 166 Query: 152 YGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLL 211 L +L R E DV V+ TS N L P D K Sbjct: 167 ---SLKTHLDRLEEVTNESGYVDVLTLLR-RVMLDTS---NTLFLRIPLDESAIVVKIQG 219 Query: 212 RFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKES--RLEDTQKHRV 269 FD + +F F I L KSVK +K++ L ++ R+ Sbjct: 220 YFDAWQALLIKPDIF-FKISWL------------YKKYEKSVKDLKDAIEVLIAEKRRRI 266 Query: 270 DFLQLMIDSQN-SKETESHKALSDL--ELVAQSII-FIFAGYETTSSVLSFIMYELATHP 325 + + + + + E + DL E V Q I+ + A +T S L F+++ +A HP Sbjct: 267 STEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHP 326 Query: 326 DVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEING 385 +V++ + +EI V+ + D + +++ ++ + E++R P+ + R +D I+G Sbjct: 327 NVEEAIIKEIQTVIGERDIKI-DDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDG 385 Query: 386 MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGM 445 + KG +++ +HR +++ +P +F E F+K N+ + PFG GPR C G Sbjct: 386 YPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENFAK----NVPYRYFQPFGFGPRGCAGK 440 Query: 446 RFALMNMKLALIRVLQNFSFK 466 A++ MK L+ +L+ F K Sbjct: 441 YIAMVMMKAILVTLLRRFHVK 461 >2WX2-A nrPDB Length = 473 Score = 75.9 bits (185), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 108/448 (24%), Positives = 179/448 (39%), Gaps = 59/448 (13%) Query: 41 PTPLPFLGNILSYHKGFCMFDMECHKKY-GKVWGFYDGQQPVLAITDPDMIKTVLV---- 95 P +PFLG+I+ + K F C + V+ G Q V + DP Sbjct: 22 PVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSRFFSPRNE 81 Query: 96 ----KECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQ 151 +E Y++ T PV F + A + + L+ T K + VP I Sbjct: 82 ILSPREVYTIMT------PV-FGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQH 134 Query: 152 YGDVLVRNLRRE--AETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKK 209 VR E E + L + GA ++ FG ++ N + F + K Sbjct: 135 E----VRKFMAENWKEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARH-FAQLLSK 189 Query: 210 LLRFDFLDPFFLSITVF-PFLIPI-LEVLNICVFPREVTNFLRKS-----VKRMKESRLE 262 + + + VF P+L+ + L C RE L+K V R KE + Sbjct: 190 M------ESSLIPAAVFMPWLLRLPLPQSARC---REARAELQKILGEIIVAREKEEASK 240 Query: 263 DTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELA 322 D D L ++ + T +S E+ + +FAG T++ S+ M L Sbjct: 241 DNNTS--DLLGGLLKAVYRDGTR----MSLHEVCGMIVAAMFAGQHTSTITTSWSMLHL- 293 Query: 323 THPDVQQ---KLQEEIDAVLPNKAPPTYDTVL-QMEYLDMVVNETLRLFPIAMRLERVCK 378 HP ++ KL +EID A YD V+ +M + + V E++R P + + R+ K Sbjct: 294 MHPKNKKWLDKLHKEIDEF---PAQLNYDNVMDEMPFAERCVRESIRRDPPLLMVMRMVK 350 Query: 379 KDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSG 438 +V++ +PKG ++ H D + + P + PER K + + FG+G Sbjct: 351 AEVKVGSYVVPKGDIIACSPLLSHHDEEAFPNPRLWDPERDEKVDG------AFIGFGAG 404 Query: 439 PRNCIGMRFALMNMKLALIRVLQNFSFK 466 CIG +FAL+ +K L + + F+ Sbjct: 405 VHKCIGQKFALLQVKTILATAFREYDFQ 432 >6B11-A nrPDB Length = 440 Score = 73.2 bits (178), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 54/213 (25%), Positives = 94/213 (44%), Gaps = 39/213 (18%) Query: 270 DFLQLMIDSQNSKET-----------ESHKALSDLELVAQSIIFIFAGYETTSSVLSFIM 318 D+L +I + +E+ LS +++ +++ + AG+ETT+S+++ + Sbjct: 233 DYLDRLISGKTGRESGDGMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMVTMSV 292 Query: 319 YELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCK 378 L HP ++L V P P V+E LR IA L R Sbjct: 293 LVLLQHPTAWREL-----TVNPGLLP-------------GAVDELLRYLSIADGLRRSAT 334 Query: 379 KDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSG 438 D+EI+G I G ++ A +RD ++EPE F R +++ + FG G Sbjct: 335 ADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHRSARR---------HVAFGYG 385 Query: 439 PRNCIGMRFALMNMKLALIRVLQNF-SFKPCKE 470 P C+G A M +++AL VL+ + +P + Sbjct: 386 PHQCLGQNLARMELEVALGAVLERLPALRPTTD 418 >4WMZ-A nrPDB Length = 539 Score = 72.4 bits (176), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 114/459 (24%), Positives = 183/459 (39%), Gaps = 70/459 (15%) Query: 44 LPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPD--------MIKTVLV 95 +P++G+ + Y F EC KKYG ++ F + + P + V Sbjct: 63 IPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSA 122 Query: 96 KECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDV 155 + Y+ T PV F K I + + + T K VP+IA+ Sbjct: 123 EAAYAHLTT-----PV-FGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLIAEEVYK 176 Query: 156 LVR---NLR-REAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLL 211 R N R E TG T+ + M + T++ SL + +T Sbjct: 177 YFRDSKNFRLNERTTG---TIDVMVTQPEMTIFTASR------SLLGKEMRAKLDTDFAY 227 Query: 212 RFDFLDPFFLSIT-VFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVD 270 + LD F I VFP N+ + + +K++ S +++ +K+ Sbjct: 228 LYSDLDKGFTPINFVFP---------NLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDI 278 Query: 271 FLQLMIDS--QNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQ 328 + +IDS +NS + K ++D E+ I + G T+++ ++I+ LA PDVQ Sbjct: 279 QDRDLIDSLMKNSTYKDGVK-MTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQ 337 Query: 329 QKLQEEIDAVLP-NKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI--NG 385 Q+L EE VL K TYD + +M L+ + ETLR+ L R KD+ + Sbjct: 338 QELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTS 397 Query: 386 MFIPKGVVVMI-PSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYI------------- 431 IP G V++ P Y RD +Y+ +F R+ N D+ Y Sbjct: 398 YVIPAGYHVLVSPGYTHLRD-EYFPNAHQFNIHRW---NNDSASSYSVGEEVDYGFGAIS 453 Query: 432 ------YTPFGSGPRNCIGMRFALMNMKLAL---IRVLQ 461 Y PFG G CIG FA + + + IR L+ Sbjct: 454 KGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLK 492 >4OQS-A nrPDB Length = 433 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 82/339 (24%), Positives = 134/339 (39%), Gaps = 70/339 (20%) Query: 125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVI 184 E R R +L FT ++KE+ P I Q + +L A+ G PV L F ++ Sbjct: 101 EHTRYRRMLISQFTVRRIKELEPRIVQ---ITEDHLDAMAKAGPPVDLVQAFALPVPSLV 157 Query: 185 TSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPRE 244 GV+ + ++ FF T + ++ E Sbjct: 158 ICELLGVS----------YADHA-----------FFQEQTTI--------MASVDKTQDE 188 Query: 245 VTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIF 304 VT L K + + E + D L +I + L+D EL +++ + Sbjct: 189 VTTALGKLTRYIAELVATKRLSPKDDLLGSLITDTD---------LTDEELTNIALLLLV 239 Query: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETL 364 AG+ETT+++L + L HP E+I A+ +P + +L+ YL +V T Sbjct: 240 AGHETTANMLGLGTFALLQHP-------EQIAAL---DSPDAVEELLR--YLSIVHLGTP 287 Query: 365 RLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK 424 R +DVE+ G I KG V I A++RDPK + EP+ Sbjct: 288 ---------NRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDIL--------QL 330 Query: 425 DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 D +D + FG G C+G + A + M++ R+ F Sbjct: 331 DRVDARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARF 369 >4Z5P-A nrPDB Length = 400 Score = 70.9 bits (172), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 77/342 (22%), Positives = 145/342 (42%), Gaps = 67/342 (19%) Query: 125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTL-KDVFGAYSMDV 183 E RLR LLS FT+ ++ M + + L+ + R TG P + +D+ +++ V Sbjct: 93 EHTRLRRLLSKAFTARRMGAMQSWLEELFAGLLDGVER---TGHPADIVRDLAQPFTIAV 149 Query: 184 ITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPR 243 I GV P+ + RF +S T + + +I + Sbjct: 150 ICRL-LGV----------PYEDRG----RFQHWSEVIMSTTAYSKEEAVSADASIRAYLA 194 Query: 244 EVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFI 303 ++ + R + D L +++ +++ + L++ EL+ + + Sbjct: 195 DLVSARRAAPHD--------------DLLGVLVSARDDDDR-----LTEDELITFGVTLL 235 Query: 304 FAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNET 363 AG+ET++ L ++Y L TH D L+E Q E L V E Sbjct: 236 VAGHETSAHQLGNMVYALLTHEDQLSLLRE------------------QPELLPRAVEEL 277 Query: 364 LRLFPIAMRL--ERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421 LR P+ + R+ +DVE++G + G V+ + +RDP+ + +P++ R + Sbjct: 278 LRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLDITR--E 335 Query: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 KN P++ FG G C+G + A M +++A+ +L+ F Sbjct: 336 KN-----PHL--AFGHGAHYCLGAQLARMELRVAIGGLLERF 370 >1Z8P-A nrPDB Length = 404 Score = 70.5 bits (171), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 59/221 (26%), Positives = 96/221 (43%), Gaps = 38/221 (17%) Query: 243 REVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIF 302 REV NF+ V+R + +D L +I Q+ + LS EL + +++ Sbjct: 190 REVVNFILDLVERRRTEPGDD-------LLSALIRVQDDDDGR----LSADELTSIALVL 238 Query: 303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 362 + AG+E++ S++ Y L THPD Q L + LPN V E Sbjct: 239 LLAGFESSVSLIGIGTYLLLTHPD-QLALVRRDPSALPN-----------------AVEE 280 Query: 363 TLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKK 422 LR R ++VEI G+ IP+ V++ + A +RDPK + +P +F R ++ Sbjct: 281 ILRYIAPPETTTRFAAEEVEIGGVAIPQYSTVLVANGAANRDPKQFPDPHRFDVTRDTRG 340 Query: 423 NKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 + FG G C+G A + ++AL + F Sbjct: 341 ---------HLSFGQGIHFCMGRPLAKLEGEVALRALFGRF 372 >4OQR-A nrPDB Length = 457 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 80/339 (23%), Positives = 132/339 (38%), Gaps = 70/339 (20%) Query: 125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVI 184 E R R +L FT ++KE+ P I + + +L A+ G PV L F ++ Sbjct: 140 EHTRYRRMLISQFTVRRIKELEPRIVR---ITEDHLDAMAKAGPPVDLVQAFALPVPSLV 196 Query: 185 TSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPRE 244 GV+ + ++ FF T ++++ E Sbjct: 197 ICELLGVS----------YADHA-----------FFQEQTTI--------MVSVDKTQDE 227 Query: 245 VTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIF 304 VT L K + + E + D L +I + L+D EL ++I + Sbjct: 228 VTTALGKLTRYIAELVATKRLSPKDDLLGSLITDTD---------LTDEELTNIALILLV 278 Query: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETL 364 AG+ETT+++L + L HP+ L +P + +L+ YL +V T Sbjct: 279 AGHETTANMLGLGTFALLQHPEQIANLD----------SPDAVEELLR--YLSIVHLGTP 326 Query: 365 RLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK 424 R +DVE+ G I KG V I A++RDPK + EP+ Sbjct: 327 ---------NRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDIL--------QL 369 Query: 425 DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 D +D + FG G C+G + A + M++ R+ F Sbjct: 370 DRVDARKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARF 408 >4GGV-A nrPDB Length = 418 Score = 69.7 bits (169), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 57/221 (25%), Positives = 97/221 (43%), Gaps = 32/221 (14%) Query: 243 REVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIF 302 R+ T LR + M E + R D L ++ ++ E L+D E+V + I Sbjct: 200 RDATERLRPLLDYMAGHVTERRRTPREDLLTHLVQAEVDGER-----LTDNEIVNVANIL 254 Query: 303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 362 + G+ TT+ L + L P+V K++ + +++P + E Sbjct: 255 LVTGHITTTMTLGNTVLCLDADPEVAAKVRAD-RSLVPG-----------------AIEE 296 Query: 363 TLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKK 422 LR+ + L R ++VE+ G IPK +VM+ A +RDP+ +T+PE + P R Sbjct: 297 ALRVLSPSAALARGTSREVEVAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVYDPTR---- 352 Query: 423 NKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 DP + FG G C+G A + ++AL + F Sbjct: 353 -----DPNPHFGFGRGIHFCLGAPLARLEGRVALNALFDRF 388 >5JLC-A nrPDB Length = 515 Score = 69.3 bits (168), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 65/264 (24%), Positives = 114/264 (43%), Gaps = 29/264 (10%) Query: 256 MKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315 +KE R ++ ++R +LM +S T+ ++D E+ I + G T+++ + Sbjct: 251 IKERREKNDIQNRDLIDELMKNSTYKDGTK----MTDQEIANLLIGVLMGGQHTSAATSA 306 Query: 316 FIMYELATHPDVQQKLQEEIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLE 374 + + LA PDVQ++L +E VL N TYD + M L+ ++ ETLRL L Sbjct: 307 WCLLHLAERPDVQEELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPLHSLF 366 Query: 375 RVCKKDVEI--NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF-------SKKNKD 425 R +DV I +P+ V++ H +++ +P +F R+ S D Sbjct: 367 RKVMRDVAIPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGD 426 Query: 426 NID------------PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK-PCKETQ 472 +D PY+ PFG G CIG FA + + + ++ ++ P + Sbjct: 427 EVDYGFGAISKGVSSPYL--PFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRYPTEGET 484 Query: 473 IPLKLSLGGLLQPEKPVVLKVESR 496 +P + P P + E R Sbjct: 485 VPPSDFTSMVTLPTAPAKIYWEKR 508 >3L4D-A nrPDB Length = 453 Score = 67.8 bits (164), Expect = 1e-11, Method: Compositional matrix adjust. Identities = 55/228 (24%), Positives = 100/228 (43%), Gaps = 29/228 (12%) Query: 260 RLEDTQKHRVDFLQLMIDSQNSKETESHKALSDL------------------ELVAQSII 301 R D + D L +I ++ +E + SDL E+ + Sbjct: 200 RCRDARAELQDILSEIIIAREKEEAQKDTNTSDLLAGLLGAVYRDGTRMSQHEVCGMIVA 259 Query: 302 FIFAGYETTSSVLSFIMYELATHPDVQQ--KLQEEIDAVLPNKAPPTYDTVLQ-MEYLDM 358 +FAG T++ ++ + L + + KL +EID A YD V++ M + + Sbjct: 260 AMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLHQEIDEF---PAQLNYDNVMEEMPFAEQ 316 Query: 359 VVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 418 E++R P + L R K V++ +P+G ++ H+D + + P ++ PER Sbjct: 317 CARESIRRDPPLVMLMRKVLKPVQVGKYVVPEGDIIACSPLLSHQDEEAFPNPREWNPER 376 Query: 419 FSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 466 N +D + FG+G CIG +F L+ +K L VL+++ F+ Sbjct: 377 ----NMKLVDG-AFCGFGAGVHKCIGEKFGLLQVKTVLATVLRDYDFE 419 >4UBS-A nrPDB Length = 393 Score = 67.4 bits (163), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 55/249 (22%), Positives = 102/249 (40%), Gaps = 42/249 (16%) Query: 223 ITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKE----SRLEDTQKHRVDFLQLMIDS 278 ++ F +P + + + P +F +R+ + ++D + D+L +ID Sbjct: 135 VSAFALPLPSMVICALLGVPYADHDFFESQSRRLLRGPGIAEVQDARAQLDDYLYALIDR 194 Query: 279 QNS-----------KETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDV 327 + +E + + ELV+ + + + AG+ETT++++S + L HP+ Sbjct: 195 KRKEPGDGLLDDLIQEQLNRGTVDRAELVSLATLLLIAGHETTANMISLGTFTLLRHPEQ 254 Query: 328 QQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMF 387 +L+ E P P V E LR IA L RV +D+E+ G Sbjct: 255 LAELRAE-----PGLMP-------------AAVEELLRFLSIADGLLRVATEDIEVAGTT 296 Query: 388 IPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRF 447 I V+ + ++RD + EP+ R ++ + FG G C+G Sbjct: 297 IRADEGVVFATSVINRDAAGFAEPDALDWHRSARH---------HVAFGFGIHQCLGQNL 347 Query: 448 ALMNMKLAL 456 A M++AL Sbjct: 348 ARAEMEIAL 356 >2X2N-A nrPDB Length = 475 Score = 66.6 bits (161), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 45/176 (25%), Positives = 83/176 (47%), Gaps = 12/176 (6%) Query: 294 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQ--QKLQEEIDAVLPNKAPPTYDTVL 351 E+ + +FAG T+S ++ M L +V+ + L++EI+ A Y+ V+ Sbjct: 266 EVCGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEF---PAQLNYNNVM 322 Query: 352 -QMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTE 410 +M + + E++R P + L R DV++ +PKG ++ H D + + E Sbjct: 323 DEMPFAERCARESIRRDPPLLMLMRKVMADVKVGSYVVPKGDIIACSPLLSHHDEEAFPE 382 Query: 411 PEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 466 P ++ PER K + FG+G CIG +F L+ +K L +++ F+ Sbjct: 383 PRRWDPERDEKVEG------AFIGFGAGVHKCIGQKFGLLQVKTILATAFRSYDFQ 432 >2VZM-A nrPDB Length = 436 Score = 64.7 bits (156), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 54/207 (26%), Positives = 92/207 (44%), Gaps = 34/207 (16%) Query: 259 SRLEDTQKHR--VDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSF 316 SRL D+++ + D L ++ + + E L+ EL+ + I + AG+ETT ++++ Sbjct: 219 SRLIDSKRGQDGEDLLSALVRTSD----EDGSRLTSEELLGMAHILLVAGHETTVNLIAN 274 Query: 317 IMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL-FPIAMRLER 375 MY L +HPD L+ + M LD V E LR P+ R Sbjct: 275 GMYALLSHPDQLAALRAD------------------MTLLDGAVEEMLRYEGPVESATYR 316 Query: 376 VCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPF 435 + V+++G IP G V++ HR P+ + +P +F R D + F Sbjct: 317 FPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHRFDIRR---------DTAGHLAF 367 Query: 436 GSGPRNCIGMRFALMNMKLALIRVLQN 462 G G CIG A + ++A+ +L+ Sbjct: 368 GHGIHFCIGAPLARLEARIAVRALLER 394 >1WIY-A nrPDB Length = 389 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 58/216 (26%), Positives = 97/216 (44%), Gaps = 33/216 (15%) Query: 282 KETES---HKALSDL---ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI 335 +E E+ H LS L +++++ + AG+ET +S L++ L+ PD Q+++ E Sbjct: 192 REAEALIVHPPLSHLPRERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRVAESE 251 Query: 336 DAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVM 395 +A E LRL+P A L R ++ + + +P+G ++ Sbjct: 252 EAA------------------LAAFQEALRLYPPAWILTRRLERPLLLGEDRLPQGTTLV 293 Query: 396 IPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLA 455 + Y R Y+ E E F PERF + Y PFG G R C+G FAL+ + Sbjct: 294 LSPYVTQR--LYFPEGEAFQPERFLAERGTPSGRYF--PFGLGQRLCLGRDFALLEGPIV 349 Query: 456 LIRVLQNFSFKPCKETQIPLKLSL---GGLLQPEKP 488 L + F P ++ +++L GGL P +P Sbjct: 350 LRAFFRRFRLDPLPFPRVLAQVTLRPEGGL--PARP 383 >6DCD-A nrPDB Length = 424 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 45/167 (26%), Positives = 82/167 (49%), Gaps = 27/167 (16%) Query: 296 VAQSIIFIFA-GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQME 354 V +S F+FA G ETT+ +L+ M L PD+Q++L+E +++PN Sbjct: 242 VVRSATFLFAAGQETTAKLLTAAMRVLGDRPDIQRRLREN-RSLIPN------------- 287 Query: 355 YLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKF 414 + E+LR+ R+ +K + G+ I G VVM+ A +RDP+ + +P +F Sbjct: 288 ----FIEESLRMDSPVKSDSRLARKRTTVGGLDIAAGTVVMVLPGAANRDPRRFEDPHEF 343 Query: 415 LPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQ 461 + ++ N+ ++ F G +C G A + +++L R+L Sbjct: 344 ------RLDRPNVREHMA--FARGVHSCPGGPLARVEGRVSLERILD 382 >4RM4-A nrPDB Length = 396 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 51/207 (24%), Positives = 85/207 (41%), Gaps = 32/207 (15%) Query: 262 EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYEL 321 E K D + ++++++ + E LS EL+ + + AG ETT++++S MY + Sbjct: 201 EKRNKPEQDIISILVEAEETGEK-----LSGEELIPFCTLLLVAGNETTTNLISNAMYSI 255 Query: 322 ATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDV 381 P V ++L+ E + V E LR A L R+ K+D Sbjct: 256 LETPGVYEELRS------------------HPELMPQAVEEALRFRAPAPVLRRIAKRDT 297 Query: 382 EINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441 EI G I +G +V+ + +RD + P F R P + FG G Sbjct: 298 EIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRRH---------PNPHIAFGHGIHF 348 Query: 442 CIGMRFALMNMKLALIRVLQNFSFKPC 468 C+G A + +AL ++ F C Sbjct: 349 CLGAPLARLEANIALTSLISAFPHMEC 375 >5CJE-A nrPDB Length = 393 Score = 64.3 bits (155), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 52/180 (28%), Positives = 75/180 (41%), Gaps = 28/180 (15%) Query: 284 TESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKA 343 E LS EL A + I + AG+ETT ++++ ++ L THPD L+ + Sbjct: 212 AEDDDRLSGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAALRAD--------- 262 Query: 344 PPTYDTVLQMEYLDMVVNETLRL-FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALH 402 M LD V E LR P+ R + +EI G I +G VMI A Sbjct: 263 ---------MTLLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIAEGDPVMIGLDAAG 313 Query: 403 RDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQN 462 RDP +P F R P + FG G C+G A + ++AL +L+ Sbjct: 314 RDPARHPDPHVFDIHRA---------PQGHLAFGHGIHYCLGAPLARLEARVALRSLLER 364 >2Z36-A nrPDB Length = 413 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 49/186 (26%), Positives = 81/186 (43%), Gaps = 33/186 (17%) Query: 270 DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQ 329 D I Q + T H L V+ + + + AG+ETT++++S + L +HP+ Sbjct: 215 DLFSRQIARQRQEGTLDHAGL-----VSLAFLLLTAGHETTANMISLGVVGLLSHPE--- 266 Query: 330 KLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRL-ERVCKKDVEINGMFI 388 Q + P + P M V E LR F IA + R+ +DVEI G+ I Sbjct: 267 --QLTVVKANPGRTP-------------MAVEELLRYFTIADGVTSRLATEDVEIGGVSI 311 Query: 389 PKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFA 448 G V++ + + DP + +P ER ++ + FG GP C+G A Sbjct: 312 KAGEGVIVSMLSANWDPAVFKDPAVLDVERGARH---------HLAFGFGPHQCLGQNLA 362 Query: 449 LMNMKL 454 M +++ Sbjct: 363 RMELQI 368 >5VWS-A nrPDB Length = 393 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 83/354 (23%), Positives = 143/354 (40%), Gaps = 61/354 (17%) Query: 112 GFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVT 171 GF K I++ + E + R L++ FT + M P I Q D L+ L G Sbjct: 72 GFGKGGITMIDPPEHRHQRRLITHAFTPQSISAMEPRIRQIADHLLDEL-----PGPEFD 126 Query: 172 LKDVFGAYSMDVIT-STSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLI 230 L + F AY + VI + GV P D + F +S+ V + Sbjct: 127 LVEHF-AYPLPVIVIAELLGVP------PGDRHL--------FRTWSDRLMSLQVENYAD 171 Query: 231 PILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKAL 290 P L + E+ ++LR+ + + R D L ++ + E E K L Sbjct: 172 PEL-ARTVAAAMTEMNDYLREHCRSRR-------THPRDDLLTRLVQA----EVEG-KRL 218 Query: 291 SDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTV 350 E+V + + + AG+ TT+ ++ M L HP+ ++ ++ + P+ P Sbjct: 219 DLEEVVNTASLLLLAGHLTTTVLIGNTMLCLWDHPEAEKAVRAD-----PSLIP------ 267 Query: 351 LQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTE 410 + E+LRL ++ RV +DV I G IP VM + + D + + + Sbjct: 268 -------AALEESLRLRSPFLQAGRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPD 320 Query: 411 PEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS 464 PE+F R + + FG G C+G + + ++AL R+L F+ Sbjct: 321 PERFDLHRQTTG---------HIAFGHGVHFCLGAQLGRLEGRIALERLLGRFT 365 >3ABB-A nrPDB Length = 408 Score = 63.5 bits (153), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 41/163 (25%), Positives = 74/163 (45%), Gaps = 27/163 (16%) Query: 294 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQM 353 E+V +++ + AG+ETT + ++ L HP E+ID +L + Sbjct: 232 EVVMIALVLLVAGHETTVNAIALGALTLIQHP-------EQIDVLLRDPG---------- 274 Query: 354 EYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEK 413 + VV E LR ++ + R+ K+D+E+ G I G V++ ++RD K + P+ Sbjct: 275 -AVSGVVEELLRFTSVSDHIVRMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDI 333 Query: 414 FLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLAL 456 F R ++ + FG G C+G A +++AL Sbjct: 334 FDARRNARH---------HVGFGHGIHQCLGQNLARAELEIAL 367 >3MGX-A nrPDB Length = 415 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 48/158 (30%), Positives = 71/158 (44%), Gaps = 28/158 (17%) Query: 303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 362 + G ETT ++ ++ LAT P + L++ +D VV E Sbjct: 252 LIGGNETTRHAITGAVHALATVPGLLTALRD------------------GSADVDTVVEE 293 Query: 363 TLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKK 422 LR AM + RV DV ING +P G V+ A +RDP + +P+ FLP R K Sbjct: 294 VLRWTSPAMHVLRVTTADVTINGRDLPSGTPVVAWLPAANRDPAEFDDPDTFLPGR--KP 351 Query: 423 NKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVL 460 N+ + FG G +C+G A + + + L RVL Sbjct: 352 NR-------HITFGHGMHHCLGSALARIELSVVL-RVL 381 >5OFQ-A nrPDB Length = 409 Score = 63.2 bits (152), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 55/219 (25%), Positives = 103/219 (47%), Gaps = 40/219 (18%) Query: 257 KESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSF 316 KE E Q + D + L+++++ E L++ E++ I+ + AG ETT+++++ Sbjct: 198 KEIIAERQQNKQEDLISLLLEAEIDGEH-----LTEEEVLGFCILLLVAGNETTTNLITN 252 Query: 317 IMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERV 376 + + DVQ +++ +I +++PN +V ETLR +P + R+ Sbjct: 253 GVRYMTEDVDVQNEVRRDI-SLVPN-----------------LVEETLRYYPPIQAIGRI 294 Query: 377 CKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFG 436 +DVE+ I +G V+ + + +RD + P+ F+ R +P++ FG Sbjct: 295 AAEDVELGECKIKRGQQVISWAASANRDSAKFEWPDTFVVHR-------KTNPHV--SFG 345 Query: 437 SGPRNCIGMRFALMNMKLALIRVL--------QNFSFKP 467 G C+G A M K+A ++L QN S KP Sbjct: 346 FGIHFCLGAPLARMEGKIAFTKLLEKGGFSKVQNQSLKP 384 >5L94-A nrPDB Length = 410 Score = 62.4 bits (150), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 52/196 (26%), Positives = 84/196 (42%), Gaps = 36/196 (18%) Query: 285 ESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAP 344 E K L+D E+V SI+ + AG ETT++++S +Y L ++L+ E Sbjct: 222 EEGKQLTDEEIVGFSILLLIAGNETTTNLISNTIYCLMEDKASFERLKRE---------- 271 Query: 345 PTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRD 404 E L + E LR L R+ K+DV + G + G V+ + HRD Sbjct: 272 --------KELLPSGIEEVLRYRSPVQALHRIVKEDVTLAGKKLKAGEHVVPWMGSAHRD 323 Query: 405 PKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQ--- 461 +Y+ +PE F +R P ++ FG G C+G A + K+ L ++ Sbjct: 324 AEYFEDPEVFKIDR---------KPNVHMAFGRGIHFCLGAPLARIEAKIMLAELIDRYP 374 Query: 462 ------NFSFKPCKET 471 +F KP + T Sbjct: 375 QMDWSPSFELKPIEST 390 >4WPZ-A nrPDB Length = 397 Score = 61.6 bits (148), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 46/184 (25%), Positives = 91/184 (49%), Gaps = 31/184 (16%) Query: 284 TESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKA 343 ++ L++ E++A SI + AG+ETT++ +S + L +P EE+D + N+ Sbjct: 211 SDGDSTLTEREIIALSIGILSAGHETTANQISMFLVTLLHNP-------EELDKLRDNR- 262 Query: 344 PPTYDTVLQMEYLDMVVNETLRLFPIAMR---LERVCKKDVEIN-GMFIPKGVVVMIPSY 399 E + V+E LR P+ + R+ +VE++ G +P G VV+ Sbjct: 263 ----------EAIPKAVDELLRFVPLTTTGGIIPRLTTAEVELSGGQVLPAGAVVLPAVA 312 Query: 400 ALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRV 459 +RDP+ + + E+ +++N +P++ FG+G +C+G + A + ++ AL + Sbjct: 313 TANRDPEVFEDGERL---NVTREN----NPHLA--FGAGIHHCLGAQLARIELQEALGAI 363 Query: 460 LQNF 463 L Sbjct: 364 LDRM 367 >5FSA-A nrPDB Length = 490 Score = 61.6 bits (148), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 67/280 (23%), Positives = 114/280 (40%), Gaps = 40/280 (14%) Query: 216 LDPFFLSIT-VFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQL 274 LD F I VFP L P+ ++++ K +K +E D + +D L Sbjct: 182 LDKGFTPINFVFPNL-PLPHYWRRDAAQKKISATYMKEIKLRRERGDIDPNRDLID--SL 238 Query: 275 MIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEE 334 +I S + ++D E+ I + G T++S ++ + L P +Q + +E Sbjct: 239 LIHSTYKDGVK----MTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIYQE 294 Query: 335 IDAVLPNKAPP----TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI--NGMFI 388 + +L K TY+ + ++ ++ + ETLR+ + R + I + Sbjct: 295 VVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPETNYIV 354 Query: 389 PKGVVVMI-PSYALHRDPKYWTEPEKFLPER----------------------FSKKNKD 425 PKG V++ P YA H +Y+ PE F P R F K +K Sbjct: 355 PKGHYVLVSPGYA-HTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGKVSKG 413 Query: 426 NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSF 465 PY+ PFG G CIG +FA + + L + N + Sbjct: 414 VSSPYL--PFGGGRHRCIGEQFAYVQLGTILTTFVYNLRW 451 >5NWS-A nrPDB Length = 435 Score = 61.2 bits (147), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 60/265 (22%), Positives = 111/265 (41%), Gaps = 44/265 (16%) Query: 214 DFLDPFF--LSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDF 271 D L+ F LSITV I E++ I E + M+ RL + +D+ Sbjct: 168 DLLEHFAYPLSITV------ICELVGIPATDLERWREWGGDLVSMRPERLRHSFPVMIDY 221 Query: 272 LQLMIDSQNSKETES------------HKALSDLELVAQSIIFIFAGYETTSSVLSFIMY 319 +I+ + + T+ LSD+E V + + AG+ET++ ++ Sbjct: 222 CHRLIEQRRAALTDDLLSELIRAQDDDGGRLSDIETVTMILTLVLAGHETSAHLIGNGTA 281 Query: 320 ELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF-PIAMRLERVCK 378 L THP Q L + A+LP V+E +R + + R Sbjct: 282 ALLTHPG-QWALLRKDPALLPR-----------------AVHELMRWCGSVHVARLRYAT 323 Query: 379 KDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSG 438 +D+E+ G + +G V + + + DP+++++P++ R + +N + FG G Sbjct: 324 EDLELAGTPVARGDAVQLVLVSANFDPRHYSDPDRLDITRHQEGQAEN-----HVGFGHG 378 Query: 439 PRNCIGMRFALMNMKLALIRVLQNF 463 C+G A ++AL R+L+ + Sbjct: 379 IHYCLGATLARQEGEVALARLLETY 403 >3BUJ-A nrPDB Length = 397 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 51/179 (28%), Positives = 75/179 (41%), Gaps = 33/179 (18%) Query: 270 DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQ 329 D L LM+D+ + +S E+V+ + FIF G+ET +S + + L HPD Sbjct: 204 DLLALMLDAHD------RGLMSRNEIVSTVVTFIFTGHETVASQVGNAVLSLLAHPDQLD 257 Query: 330 KLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIP 389 L+ D L V E LR P R DVE+ G + Sbjct: 258 LLRRRPD------------------LLAQAVEECLRYDPSVQSNTRQLDVDVELRGRRLR 299 Query: 390 KGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFA 448 + VV++ + A +RDP+ + P+ F ER DP FG+G R C+G A Sbjct: 300 RDDVVVVLAGAANRDPRRYDRPDDFDIER---------DPVPSMSFGAGMRYCLGSYLA 349 >3A50-A nrPDB Length = 411 Score = 60.8 bits (146), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 48/174 (27%), Positives = 84/174 (48%), Gaps = 28/174 (16%) Query: 290 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 349 LS ELVA +++ + AG+ETT +++ + L THPD Q+KL E +++ + Sbjct: 221 LSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPD-QRKLLAEDPSLISS-------- 271 Query: 350 VLQMEYLDMVVNETLRL-FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYW 408 V E LR P++ R +DV +G+ IP G +VM+ A +RD + Sbjct: 272 ---------AVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWM 322 Query: 409 TEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQN 462 EP++ R + ++ FG G C+G + A + ++A+ R+ + Sbjct: 323 PEPDRLDITRDASGG-------VF--FGHGIHFCLGAQLARLEGRVAIGRLFAD 367 >1UE8-A nrPDB Length = 367 Score = 60.1 bits (144), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 51/204 (25%), Positives = 89/204 (43%), Gaps = 36/204 (17%) Query: 269 VDFLQLMIDSQNSKETE------SHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELA 322 + F + +DS+ KE ++ LS+LE I+ + AG ETT++++ + + Sbjct: 168 ISFSKKELDSRKGKEIVDLTGKIANSNLSELEKEGYFILLMIAGNETTTNLIGNAIEDFT 227 Query: 323 THPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVE 382 + ++D V + L V E LR P MR RV K+ V+ Sbjct: 228 LYN--------------------SWDYVREKGAL-KAVEEALRFSPPVMRTIRVTKEKVK 266 Query: 383 INGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNC 442 I I +G +V + + +RD + + +P+ F+P+R P + FGSG C Sbjct: 267 IRDQVIDEGELVRVWIASANRDEEVFKDPDSFIPDR---------TPNPHLSFGSGIHLC 317 Query: 443 IGMRFALMNMKLALIRVLQNFSFK 466 +G A + ++AL + F K Sbjct: 318 LGAPLARLEARIALEEFAKKFRVK 341 >6A7I-A nrPDB Length = 411 Score = 59.3 bits (142), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 52/183 (28%), Positives = 81/183 (44%), Gaps = 31/183 (16%) Query: 284 TESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKA 343 +E+ L+D E+V + I AG+ETT S++ ++ L THP+ ++K Sbjct: 219 SENGDHLTDEEIVNTLQLIIAAGHETTISLIVNVVEALQTHPEQRKK------------- 265 Query: 344 PPTYDTVLQMEY-LDMVVNETLRL-FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYAL 401 VL E D V+ ETLR P + L R +D+E+ +PKG ++I AL Sbjct: 266 ------VLNGEIGWDGVIEETLRWNTPTSHVLIRFATEDIEVGDKILPKGEGLIISFGAL 319 Query: 402 HRD-PKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVL 460 RD +Y +F R P + FG GP C G + + +AL + Sbjct: 320 GRDEEQYGPTAGEFDATRT---------PNRHIAFGHGPHVCPGAALSRLEAGIALPALY 370 Query: 461 QNF 463 + F Sbjct: 371 ERF 373 >5FYF-A nrPDB Length = 470 Score = 58.9 bits (141), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 53/211 (25%), Positives = 97/211 (45%), Gaps = 34/211 (16%) Query: 255 RMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSD--LELVAQSIIFIFAGYETTSS 312 R KE+R ++ D + L+ Q++KET K L + +E + + I G +TT + Sbjct: 261 RDKEARRAAGEEPGFDLISLL---QSNKET---KDLINRPMEFIGNLTLLIVGGNDTTRN 314 Query: 313 VLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMR 372 +S + + P +KL KA P E + +V+E +R Sbjct: 315 SMSGGLVAMNEFPREFEKL----------KAKP--------ELIPNMVSEIIRWQTPLAY 356 Query: 373 LERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIY 432 + R+ K+DVE+ G I KG V++ + +RD + + P++F+ +R +N + Sbjct: 357 MRRIAKQDVELGGQTIKKGDRVVMWYASGNRDERKFDNPDQFIIDRKDARN--------H 408 Query: 433 TPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 FG G C+G R A + +++ +L+ F Sbjct: 409 MSFGYGVHRCMGNRLAELQLRILWEEILKRF 439 >1GWI-A nrPDB Length = 411 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 93/399 (23%), Positives = 161/399 (40%), Gaps = 71/399 (17%) Query: 71 VWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI--AEDEEWKR 128 VW + +TDP ++K + V + + +G S+ + E +R Sbjct: 43 VWAVTHHAEAKALLTDPRLVKDINVWGAWRRGEIPADWPLIGLANPGRSMLTVDGAEHRR 102 Query: 129 LRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV-ITST 187 LR+L++ T +++ M I + D L+ L + G V LK F AY + + + + Sbjct: 103 LRTLVAQALTVRRVEHMRGRITELTDRLLDELPAD---GGVVDLKAAF-AYPLPMYVVAD 158 Query: 188 SFGVNIDSLNNPQDPFVENTKKLLRFDFL-DPFFLSITVFPFLIPILEVLNICVFPREVT 246 G+ +L R L + FF + T P EV+ E+ Sbjct: 159 LMGIE--------------EARLPRLKVLFEKFFSTQT------PPEEVVATLT---ELA 195 Query: 247 NFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAG 306 + + +V + + +D + S + +E+ L+D E+V+ + + AG Sbjct: 196 SIMTDTVAAKRAAPGDD------------LTSALIQASENGDHLTDAEIVSTLQLMVAAG 243 Query: 307 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 366 +ETT S++ + L+THP+ Q+ L VL +A E+ VV ETLR Sbjct: 244 HETTISLIVNAVVNLSTHPE-QRAL------VLSGEA----------EW-SAVVEETLRF 285 Query: 367 -FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPK-YWTEPEKFLPERFSKKNK 424 P + L R +DV + IP G +++ AL RD + + ++F R S Sbjct: 286 STPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTADRFDLTRTSGNR- 344 Query: 425 DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 + FG GP C G + M +AL + F Sbjct: 345 -------HISFGHGPHVCPGAALSRMEAGVALPALYARF 376 >5XNT-A nrPDB Length = 411 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 95/418 (22%), Positives = 165/418 (39%), Gaps = 81/418 (19%) Query: 51 LSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGP 110 +SYH+G W + + ++D +V + SV T+ Sbjct: 35 VSYHEG------------TDTWNVFKYEDVKRVLSDYKHFSSVRKRTTISVGTDSEE--- 79 Query: 111 VGFMKSAISIAEDE--EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGK 168 G + I I E + E ++ RSLL+ FT L+ P I + D L+ + E E Sbjct: 80 -GSVPDKIKITEADPPEHRKRRSLLAAAFTPRSLQNWEPRIQEIADELIEEMDEETE--- 135 Query: 169 PVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPF 228 +D++ S + + I +++ V + +LL ++D FL PF Sbjct: 136 ------------IDIVQSLASPLPIIVMSDLMG--VPSKDRLLFKKWVDILFL-----PF 176 Query: 229 LIPILEVLNIC--VFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETES 286 E +N V +E +L V + RL D L+ +D + Sbjct: 177 DKEKQEEVNELKQVAAKEYYQYLYPIV---VQKRLNPADDIISDLLKAEVDGE------- 226 Query: 287 HKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELA-THPDVQQKLQEEIDAVLPNKAPP 345 +D E+V +++ + AG ETTS +L+ Y L +V Q+L E +D V Sbjct: 227 --MFTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHENLDLV------- 277 Query: 346 TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDP 405 V E LR ++L+R K+D ++ G+ + +G V++ A + D Sbjct: 278 -----------PQAVEEMLRYRFNLIKLDRTVKEDNDLLGVELKEGENVVVWMSAANLDE 326 Query: 406 KYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 + + + R + K + FG+GP C+G A + K+AL L+ F Sbjct: 327 EMFEDAFTLNIHRPNNKK--------HLTFGNGPHFCLGAPLARLEAKIALTTFLKKF 376 >3AWQ-A nrPDB Length = 415 Score = 58.5 bits (140), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 57/225 (25%), Positives = 90/225 (40%), Gaps = 36/225 (16%) Query: 262 EDTQKHRVDFLQLMIDSQNS---KETESHKALSDLELVAQSII-FIFAGYETTSSVLSFI 317 +D +R L+ + D+ S + S A ++ A+ II I AG + S Sbjct: 155 DDEAGNRAGELRALFDAAGSASPRHLWSRLARRRVDAWAKRIIEGIRAG--SIGSGSGTA 212 Query: 318 MYELATHPDVQQKL-------QEEIDAVLPNKAPPTYDT----------------VLQME 354 Y +A H D L E ++ + P A Y T V Q + Sbjct: 213 AYAIAWHRDRHDDLLSPHVAAVELVNVLRPTVAIAVYITFVAHALQTCSGIRAALVQQPD 272 Query: 355 YLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKF 414 Y ++ V E R +P + +D E GM P+G V++ Y + D W +P++F Sbjct: 273 YAELFVQEVRRFYPFFPAVVARASQDFEWEGMAFPEGRQVVLDLYGSNHDAATWADPQEF 332 Query: 415 LPERFSKKNKDNIDPYIYTPFGSGP----RNCIGMRFALMNMKLA 455 PERF ++D+ + + P G G C G L MK+A Sbjct: 333 RPERFRAWDEDSFN---FIPQGGGDHYLGHRCPGEWIVLAIMKVA 374 >2WIO-A nrPDB Length = 431 Score = 58.5 bits (140), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 46/177 (25%), Positives = 72/177 (40%), Gaps = 25/177 (14%) Query: 288 KALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTY 347 +AL D E S + AG+ TT+ +L I+ L HP E+ P + P Sbjct: 244 RALDDEEAANFSTALLLAGHITTTVLLGNIVRTLDEHPAHWDAAAED-----PGRIP--- 295 Query: 348 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKY 407 +V E LR P +++R K E+ G+ IP V+V + +RD Sbjct: 296 ----------AIVEEVLRYRPPFPQMQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDA 345 Query: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS 464 +P++F P R S FG G C+G A + ++AL ++ F Sbjct: 346 HDDPDRFDPSRKSGGAA-------QLSFGHGVHFCLGAPLARLENRVALEEIIARFG 395 >4YT3-A nrPDB Length = 410 Score = 58.2 bits (139), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 93/418 (22%), Positives = 164/418 (39%), Gaps = 81/418 (19%) Query: 51 LSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGP 110 +SYH+G W + + ++D +V + SV T+ Sbjct: 35 VSYHEG------------TDTWNVFKYEDVKRVLSDYKHFSSVRKRTTISVGTDSEE--- 79 Query: 111 VGFMKSAISIAEDE--EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGK 168 G + I I E + + ++ RSLL+ FT L+ P I + D L+ + Sbjct: 80 -GSVPEKIQITESDPPDHRKRRSLLAAAFTPRSLQNWEPRIQEIADELIGQMD------- 131 Query: 169 PVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPF 228 G +D++ S + + I + + V + +LL ++D FL PF Sbjct: 132 --------GGTEIDIVASLASPLPIIVMADLMG--VPSKDRLLFKKWVDTLFL-----PF 176 Query: 229 LIPILEVLNIC--VFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETES 286 E ++ V +E +L V + RL D L+ +D + Sbjct: 177 DREKQEEVDKLKQVAAKEYYQYLYPIVV---QKRLNPADDIISDLLKSEVDGE------- 226 Query: 287 HKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELA-THPDVQQKLQEEIDAVLPNKAPP 345 +D E+V +++ + AG ETTS +L+ Y L +V Q+L E +D V Sbjct: 227 --MFTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHENLDLV------- 277 Query: 346 TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDP 405 V E LR ++L+R K+D ++ G+ + +G V++ A + D Sbjct: 278 -----------PQAVEEMLRFRFNLIKLDRTVKEDNDLLGVELKEGDSVVVWMSAANMDE 326 Query: 406 KYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 + + +P R + K + FG+GP C+G A + K+AL L+ F Sbjct: 327 EMFEDPFTLNIHRPNNKK--------HLTFGNGPHFCLGAPLARLEAKIALTAFLKKF 376 >5YSW-A nrPDB Length = 441 Score = 58.2 bits (139), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 53/191 (27%), Positives = 90/191 (47%), Gaps = 31/191 (16%) Query: 289 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYD 348 AL+D EL+ + + + AGY+TT+S+L ++ L P L+++ P++ + Sbjct: 261 ALTDDELINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDD-----PSRIADAVE 315 Query: 349 TVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYW 408 +L+ YL VVN + F K+D+E G IP G V++ A +RD ++W Sbjct: 316 ELLR--YLS-VVNPGIFRF---------AKEDLEFAGEHIPAGSTVVVSVVATNRDARHW 363 Query: 409 TEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLA---LIRVLQNFSF 465 +P+ L P++ FG G C+G + A M M+ L+R L N Sbjct: 364 PDPDLDLTRPRG--------PHLA--FGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRL 413 Query: 466 KPCKETQIPLK 476 E ++PL+ Sbjct: 414 AVPPE-EVPLR 423 >3EJB-B nrPDB Length = 404 Score = 57.8 bits (138), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 46/172 (26%), Positives = 74/172 (43%), Gaps = 27/172 (15%) Query: 290 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 349 L++ E + I+ AG+ETT +++S + L HP+ KL+E D + Sbjct: 219 LTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLI----------- 267 Query: 350 VLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWT 409 V E LR RV +D++I G+ I +G V + A +RDP +T Sbjct: 268 -------GTAVEECLRYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFT 320 Query: 410 EPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQ 461 P+ F R P + FG G C+G A + ++A+ +LQ Sbjct: 321 NPDVFDITR---------SPNPHLSFGHGHHVCLGSSLARLEAQIAINTLLQ 363 >5XW2-A nrPDB Length = 419 Score = 57.4 bits (137), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 55/247 (22%), Positives = 108/247 (43%), Gaps = 47/247 (19%) Query: 249 LRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYE 308 +RK ++ ++E E ++ R D + +I+++ + L+D +V + + + AGY Sbjct: 205 MRKMLEYLREHAAECRRRPRGDLMGKLIEAEVDG-----RRLTDNHIVNFAKMLLIAGYL 259 Query: 309 TTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP 368 TT+ ++ + L ++P+ +++ + +++P ++ E++R Sbjct: 260 TTTMLIGNTVLCLDSYPEQAARVRAD-RSLIPG-----------------LLEESMRFLS 301 Query: 369 IAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID 428 R +DVE+ G + +VM+ A +RD + + EPE F R Sbjct: 302 PVAATYRATTRDVEVAGQRLSADQMVMVWFGAANRDARQFAEPELFDMTR---------G 352 Query: 429 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF-----------SFKPCKET----QI 473 P + FG G C+G A M ++AL +L F +F P +T + Sbjct: 353 PNPHLGFGRGIHFCLGGPLARMEGRVALDHLLDRFPELYTDPERPPTFMPGFDTTGVSSL 412 Query: 474 PLKLSLG 480 PL+ SLG Sbjct: 413 PLRTSLG 419 >3OFT-A nrPDB Length = 396 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 40/151 (26%), Positives = 70/151 (46%), Gaps = 26/151 (17%) Query: 302 FIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVN 361 +F G +T ++++ + LA HP+ Q+ L+E D ++P A + Sbjct: 231 LLFGGLDTVAAMIGMVALHLARHPEDQRLLRERPD-LIPAAA-----------------D 272 Query: 362 ETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421 E +R +P + + R DV+ +G+ I KG +V +PS + DP + PE+ RF + Sbjct: 273 ELMRRYP-TVAVSRNAVADVDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEV---RFDR 328 Query: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNM 452 + P +T G G C+G A M + Sbjct: 329 ----GLAPIRHTTMGVGAHRCVGAGLARMEV 355 >3NC3-A nrPDB Length = 441 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 83/367 (22%), Positives = 149/367 (40%), Gaps = 44/367 (11%) Query: 99 YSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLS--PTFTSGKLKEMVPIIAQYGDVL 156 Y+ F+ R PV + +S I + +R +L FT+ L E + + G VL Sbjct: 56 YAYFSQLREEDPVHYEES-IDSYFISRYHDVRYILQHPDIFTTKSLVERAEPVMR-GPVL 113 Query: 157 VRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFL 216 + +E + + ++ G D + S + ++ N P++E K L DF Sbjct: 114 AQMHGKEHSAKRRIVVRSFIG----DALDHLSPLIKQNA-ENLLAPYLERGKSDLVNDFG 168 Query: 217 DPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLED------------- 263 F + +T+ + + I + V +F+ S+ + E+R Sbjct: 169 KTFAVCVTMDMLGLDKRDHEKISEWHSGVADFI-TSISQSPEARAHSLWCSEQLSQYLMP 227 Query: 264 -TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELA 322 ++ RV+ +I + E E ALSD +++A + + A E L+ ++Y L Sbjct: 228 VIKERRVNPGSDLISILCTSEYEG-MALSDKDILALILNVLLAATEPADKTLALMIYHLL 286 Query: 323 THPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVE 382 +P E+++ VL +++ + + ETLR P + R +D Sbjct: 287 NNP-------EQMNDVLADRS-----------LVPRAIAETLRYKPPVQLIPRQLSQDTV 328 Query: 383 INGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYI-YTPFGSGPRN 441 + GM I K +V A +RDP+ + +P+ F R K + FGSG N Sbjct: 329 VGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIKSAFSGAARHLAFGSGIHN 388 Query: 442 CIGMRFA 448 C+G FA Sbjct: 389 CVGTAFA 395 >4JBT-A nrPDB Length = 410 Score = 56.6 bits (135), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 86/385 (22%), Positives = 149/385 (38%), Gaps = 66/385 (17%) Query: 84 ITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI--AEDEEWKRLRSLLSPTFTSGK 141 +TD ++K + + T R + +G + S+ + E +RLR + T + Sbjct: 55 LTDTRLVKDINAWSLWQSGTVTRQWPLIGMIDVDRSMFTVDGPEHRRLRIKTTQALTRRR 114 Query: 142 LKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV-ITSTSFGVNIDSLNNPQ 200 L + P I +Y L+ +L R G V LK VF AY + + + S GV Sbjct: 115 LDALKPTIERYVAELLDDLERAGADGAVVDLKSVF-AYPLPMRVISALMGVP-------- 165 Query: 201 DPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESR 260 E+ ++LL + F L P E L + E+ + + V+R Sbjct: 166 ---SEDQEQLLTW--------YKAFFSILTPQDERLRVI---DEMHGYFTEMVRRKTAEP 211 Query: 261 LEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYE 320 +D + S T+ L++ E++ + AG+ETT S++ + Sbjct: 212 GDD------------LTSALIYATDGETPLTEEEVIGNLQALVAAGHETTVSLILTAVRA 259 Query: 321 LATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL-FPIAMRLERVCKK 379 L +HP+ Q +L D + E + ETLR P+ L R + Sbjct: 260 LLSHPE-QLRL--------------VRDGEIGWE---TAIEETLRWDGPVIHLLMRFATE 301 Query: 380 DVEINGMFIPKGVVVMIPSYALHRD-PKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSG 438 D+++ IP+G V++ A+ RD + + + F R + + FG G Sbjct: 302 DIDLGDAVIPRGEGVVMSYRAIGRDITVHGADADDFDITRATAAR--------HISFGHG 353 Query: 439 PRNCIGMRFALMNMKLALIRVLQNF 463 P C G A + +AL + F Sbjct: 354 PHICPGAALARLEAAIALPALFTRF 378 >6HQW-A nrPDB Length = 445 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 44/187 (23%), Positives = 80/187 (42%), Gaps = 32/187 (17%) Query: 270 DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQ 329 D + +MI S E+ +S E + ++ I G +TT + +S I++ L PD Q+ Sbjct: 254 DLISMMIHS------EAMNHMSPQEFMGNLVLLIVGGNDTTRNTMSGIVHALDKFPD-QR 306 Query: 330 KLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIP 389 +L E +++PN V E +R + R D E+ G I Sbjct: 307 ELLERDASLIPN-----------------AVQECIRYVTPLAHMRRTATADTELFGNQIK 349 Query: 390 KGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449 G V++ + +RD + P+K + +R + + + FG G C+G R A Sbjct: 350 AGEKVILWYISANRDETVFENPDKLMVDRPNARR--------HLSFGHGIHRCVGARLAE 401 Query: 450 MNMKLAL 456 + +++ L Sbjct: 402 LQLRILL 408 >1F4U-A nrPDB Length = 368 Score = 56.6 bits (135), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 46/167 (27%), Positives = 82/167 (49%), Gaps = 29/167 (17%) Query: 290 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 349 LSD+E + I+ + AG ETT++++S + + T ++ Q+++EE Sbjct: 194 LSDIEKLGYIILLLIAGNETTTNLISNSVIDF-TRFNLWQRIREE--------------- 237 Query: 350 VLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWT 409 YL + E LR P MR R K+ V++ I +G V + + +RD + + Sbjct: 238 ---NLYL-KAIEEALRYSPPVMRTVRKTKERVKLGDQTIEEGEYVRVWIASANRDEEVFH 293 Query: 410 EPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLAL 456 + EKF+P+R N +P++ FGSG C+G A + ++A+ Sbjct: 294 DGEKFIPDR-------NPNPHL--SFGSGIHLCLGAPLARLEARIAI 331 >3R9C-A nrPDB Length = 418 Score = 56.2 bits (134), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 45/205 (21%), Positives = 79/205 (38%), Gaps = 38/205 (18%) Query: 270 DFLQLMIDSQNSKE-----------TESHKALSDLELVAQSIIFIFAGYETTSSVLSFIM 318 D+L+ +ID + ES L++ E++A + + AG+ETT ++++ Sbjct: 210 DYLRALIDERRRTPGEDLMSGLVAVEESGDQLTEDEIIATCNLLLIAGHETTVNLIANAA 269 Query: 319 YELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCK 378 + P L + V+ ET+R P + R Sbjct: 270 LAMLRTPGQWAALAAD------------------GSRASAVIEETMRYDPPVQLVSRYAG 311 Query: 379 KDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSG 438 D+ I +PKG +++ A HRDP P++F P+R + + FG G Sbjct: 312 DDLTIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDPDRAQIR---------HLGFGKG 362 Query: 439 PRNCIGMRFALMNMKLALIRVLQNF 463 C+G A + +AL + F Sbjct: 363 AHFCLGAPLARLEATVALPALAARF 387 >3WVS-A nrPDB Length = 401 Score = 55.5 bits (132), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 44/196 (22%), Positives = 85/196 (43%), Gaps = 34/196 (17%) Query: 270 DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQ 329 D + MI++++ ++ L++ EL+ I + AG+ETT+S + +Y L P + Sbjct: 211 DLISGMIEARDVQDK-----LTEQELLDHCIGLLIAGHETTASQIPSFVYALLDQPQHWK 265 Query: 330 KLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPI--AMRLERVCKKDVEINGMF 387 +L ++ E + V E R P+ R ++D+E+ G Sbjct: 266 RLLDD------------------PELIPSAVEELFRFVPLGSGSAAPRYAREDIEVGGTL 307 Query: 388 IPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRF 447 + G V++ A +RD + +PE+ +R S + FG G +C+G Sbjct: 308 VRAGEPVLVALGAANRDGLRFEDPEEIKLDRPSNH---------HIGFGHGIHHCLGAPL 358 Query: 448 ALMNMKLALIRVLQNF 463 A + ++ AL +L+ Sbjct: 359 ARLELQEALRALLERL 374 >6A7J-A nrPDB Length = 411 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 49/182 (26%), Positives = 80/182 (43%), Gaps = 29/182 (15%) Query: 284 TESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKA 343 +E L+D E++ + I AG+ETT S++ ++ LA HP+ ++K VL + Sbjct: 219 SEDGDHLTDEEILNTLQLIIAAGHETTISLIVNVVEALAIHPEQRKK-------VLSGEI 271 Query: 344 PPTYDTVLQMEYLDMVVNETLRL-FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALH 402 P + V+ ETLR P + L R +D+E+ +PKG +++ AL Sbjct: 272 P-----------WEGVIEETLRWNTPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALG 320 Query: 403 RD-PKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQ 461 RD +Y F R P + FG GP C G + + +AL + + Sbjct: 321 RDEEQYGPTAGDFDATRT---------PNRHIAFGHGPHVCPGAALSRLEAGIALPALYE 371 Query: 462 NF 463 F Sbjct: 372 RF 373 >2Y5N-A nrPDB Length = 417 Score = 55.5 bits (132), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 53/227 (23%), Positives = 103/227 (45%), Gaps = 40/227 (17%) Query: 270 DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQ 329 D + ++ +++ +++ LS+ EL+ +I + AGYE+T++ ++ +Y L T P++++ Sbjct: 224 DLVSALVQARDQQDS-----LSEQELLDLAIGLLVAGYESTTTQIADFVYLLMTRPELRR 278 Query: 330 KLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP--IAMRLERVCKKDVEINGMF 387 +L + + E + V E R P + R +DV + G+ Sbjct: 279 QLLD------------------RPELIPSAVEELTRWVPLGVGTAFPRYAVEDVTLRGVT 320 Query: 388 IPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID--PYIYTPFGSGPRNCIGM 445 I G V+ + A +RD +F ++ ++D P + FG G +C+G Sbjct: 321 IRAGEPVLASTGAANRDQA-----------QFPDADRIDVDRTPNQHLGFGHGVHHCLGA 369 Query: 446 RFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQP--EKPVV 490 A + +++AL +LQ + L+ S G LL+ E PVV Sbjct: 370 PLARVELQVALEVLLQRLPGIRLGIPETQLRWSEGMLLRGPLELPVV 416 >3NV6-A nrPDB Length = 452 Score = 55.1 bits (131), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 58/213 (27%), Positives = 94/213 (44%), Gaps = 41/213 (19%) Query: 270 DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQ 329 D + LM++S+ + E +H L + +T + LSF M LA HP++ Sbjct: 260 DLITLMVNSEINGERIAHDKAQGLISLLLLGG-----LDTVVNFLSFFMIHLARHPELVA 314 Query: 330 KLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIP 389 +L+ + P K L E R FP+ R+ KD E G+F+ Sbjct: 315 ELRSD-----PLK-------------LMRGAEEMFRRFPVVSEA-RMVAKDQEYKGVFLK 355 Query: 390 KGVVVMIPSYALHR-DPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFA 448 +G ++++P+ ALH D EP K FS+++ ++ FG GP C GM A Sbjct: 356 RGDMILLPT-ALHGLDDAANPEPWKL---DFSRRS------ISHSTFGGGPHRCAGMHLA 405 Query: 449 LMNMKLAL---IRVLQNFSFKPCKETQIPLKLS 478 M + + L ++ + FSF KE + P+ S Sbjct: 406 RMEVIVTLEEWLKRIPEFSF---KEGETPIYHS 435 >6HQG-A nrPDB Length = 425 Score = 55.1 bits (131), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 45/179 (25%), Positives = 75/179 (41%), Gaps = 26/179 (14%) Query: 285 ESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAP 344 ES K + +E + I+ I G +TT + +S + L +PD +KL+E P P Sbjct: 242 ESTKNMDRMEYLGNLILLIVGGNDTTRNTISGSVLALHQNPDQDRKLREN-----PGLIP 296 Query: 345 PTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRD 404 +V+ET+R + R K+D E+ G I +G V + + +RD Sbjct: 297 -------------AMVSETIRWQTPLAYMRRRAKRDFELGGKTIREGDKVAMWYVSGNRD 343 Query: 405 PKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 + P + ER + + FG G C+G R A + +K+ +L F Sbjct: 344 EEVIDRPNDYWIERPRVRQ--------HLSFGFGVHRCVGNRLAELQLKIIWEEILARF 394 >6GK6-A nrPDB Length = 411 Score = 54.7 bits (130), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 47/182 (25%), Positives = 78/182 (42%), Gaps = 29/182 (15%) Query: 283 ETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNK 342 E + HK LS EL + + + AG+ETT +++ M L +HP +++L E+ V Sbjct: 222 EEQEHK-LSPAELSSMVFLLLVAGHETTVHLIASGMLLLLSHPAERRRLDEDPGLV---- 276 Query: 343 APPTYDTVLQMEYLDMVVNETLRL-FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYAL 401 V E LR P + R +D+E+ G +P G V A Sbjct: 277 --------------GSAVEEALRCEGPAELSTIRWSLEDIELFGARVPAGEGVAAGLLAA 322 Query: 402 HRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQ 461 +RDP+++ +P++F R P + FG G C+G A + +A +L+ Sbjct: 323 NRDPQHFPDPDRFDIGR---------SPNRHIGFGGGIHFCLGAMLARIEAAIAFSTLLR 373 Query: 462 NF 463 Sbjct: 374 RL 375 >3SN5-A nrPDB Length = 491 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 66/285 (23%), Positives = 117/285 (41%), Gaps = 36/285 (12%) Query: 206 NTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKES-RLEDT 264 +T+K + LD F VFP L+ L P + + +++ ES R E+ Sbjct: 179 DTQKAHILNNLDNFKQFDKVFPALVAGL--------PIHMFRTAHNAREKLAESLRHENL 230 Query: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324 QK R +L+ +T S DLE ++ ++A T + ++++ + Sbjct: 231 QK-RESISELISLRMFLNDTLS--TFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRN 287 Query: 325 PDVQQKLQEEIDAVLPNKAPP----------TYDTVLQMEYLDMVVNETLRLFPIAMRLE 374 P+ + EE+ L N + + + LD ++ E+LRL ++ + Sbjct: 288 PEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI- 346 Query: 375 RVCKKD----VEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID-- 428 R K+D +E I K ++ + +H DP+ + +P F +R+ +N Sbjct: 347 RTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTF 406 Query: 429 -------PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 466 Y Y PFGSG C G FA+ +K LI +L F + Sbjct: 407 YCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELE 451 >2ZBZ-A nrPDB Length = 412 Score = 54.3 bits (129), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 39/164 (23%), Positives = 73/164 (44%), Gaps = 28/164 (17%) Query: 294 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQM 353 EL++ +++ + AG+ETT+S+ S + L HP+ L+ + +++P Sbjct: 233 ELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRAD-RSLVPG------------ 279 Query: 354 EYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPE 412 V E LR IA + RV D+E+ G I G V++ + +RD + +P+ Sbjct: 280 -----AVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRDGTVYEDPD 334 Query: 413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLAL 456 R ++ + FG G C+G A + +++ L Sbjct: 335 ALDIHRSARH---------HLAFGFGVHQCLGQNLARLELEVIL 369 >6FYJ-A nrPDB Length = 421 Score = 53.9 bits (128), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 42/171 (24%), Positives = 69/171 (40%), Gaps = 24/171 (14%) Query: 290 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 349 L D E A +I I + ++FI L +P+ ++KL+ Sbjct: 231 LLDTETAAVEVINILRPIVAIAIFINFIALALHHYPEEKEKLKSG--------------- 275 Query: 350 VLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWT 409 +Y M V E R +P + + KKD G +G + ++ Y + DP+ W Sbjct: 276 --DKKYSQMFVQEVRRFYPFFPFVVALVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWK 333 Query: 410 EPEKFLPERFSKKNKDNIDPYIYTPFGSGP----RNCIGMRFALMNMKLAL 456 P+ F P+RF+K P+ + P G G C G + MK++L Sbjct: 334 NPDVFSPDRFAKWEG---SPFSFIPQGGGDYFMGHRCAGEWVTIEVMKVSL 381 >5HDI-A nrPDB Length = 404 Score = 53.9 bits (128), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 41/165 (24%), Positives = 70/165 (42%), Gaps = 26/165 (15%) Query: 300 IIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMV 359 + AG E+T+++L ++ LAT PD+QQ++ +A P E L Sbjct: 239 VTLFAAGGESTAALLGSAVWILATRPDIQQQV----------RANP--------ELLGAF 280 Query: 360 VNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF 419 + ETLR P R + ++G +P +++ A +RDP + P +F +R Sbjct: 281 IEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRA 340 Query: 420 SKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS 464 K + FG G C+G A + ++ L +L S Sbjct: 341 GGKG--------HISFGKGAHFCVGAALARLEARIVLRLLLDRTS 377 >2ZQJ-A nrPDB Length = 417 Score = 53.1 bits (126), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 32/104 (30%), Positives = 48/104 (46%), Gaps = 7/104 (6%) Query: 357 DMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLP 416 +M V E R +P L + KKD N KG V++ Y + DP+ W P++F P Sbjct: 277 EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEFRP 336 Query: 417 ERFSKKNKDNIDPYIYTPFGSG----PRNCIGMRFALMNMKLAL 456 ERF+++ ++ D P G G C G + MK +L Sbjct: 337 ERFAEREENLFD---MIPQGGGHAEKGHRCPGEGITIEVMKASL 377 >3TKT-A nrPDB Length = 450 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 42/167 (25%), Positives = 71/167 (42%), Gaps = 27/167 (16%) Query: 290 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 349 +SD + II AG++TTS+ + LA PD+ +++ + + +LP Sbjct: 274 MSDRDTAGYYIITASAGHDTTSASSAGAALALARDPDLFARVKADRN-LLPG-------- 324 Query: 350 VLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWT 409 +V E +R R D E+ G I G +M+ A + DP + Sbjct: 325 ---------IVEEAIRWTTPVQHFMRTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFP 375 Query: 410 EPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLAL 456 EP KF P R + + + FG+G C+G+ A + M++ L Sbjct: 376 EPRKFDPTRPANR---------HLAFGAGSHQCLGLHLARLEMRVLL 413 >2XKR-A nrPDB Length = 398 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 48/183 (26%), Positives = 77/183 (42%), Gaps = 28/183 (15%) Query: 281 SKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLP 340 S E + + LSD ELV ++++ + G ETT LS +L + D LQ + ++LP Sbjct: 207 SSEVDGER-LSDDELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRDP-SLLP 264 Query: 341 NKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYA 400 + E LR + RV D E +G + G +M+ + Sbjct: 265 G-----------------AIEEMLRWTAPVKNMCRVLTADTEFHGTALCAGEKMMLLFES 307 Query: 401 LHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVL 460 + D + EPEKF +R +P + FG G C+G + A + + L RVL Sbjct: 308 ANFDEAVFCEPEKFDVQR---------NPNSHLAFGFGTHFCLGNQLARLELSLMTERVL 358 Query: 461 QNF 463 + Sbjct: 359 RRL 361 >5FOI-A nrPDB Length = 408 Score = 52.0 bits (123), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 38/163 (23%), Positives = 71/163 (43%), Gaps = 27/163 (16%) Query: 294 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQM 353 ELV +++ + AG+ET+++ ++ + L HP+ +L+E+ + ++PN Sbjct: 236 ELVNNAVLLLAAGHETSANQVTLSVLTLLRHPETAAELREQPE-LMPN------------ 282 Query: 354 EYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEK 413 V+E LR IA L R D+ + I G ++I + + D + Sbjct: 283 -----AVDELLRYHSIADGLRRAATADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEAT 337 Query: 414 FLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLAL 456 F R ++ + FG GP C+G A + M++ L Sbjct: 338 FDIHRPARH---------HVAFGYGPHQCLGQNLARLEMEVTL 371 >3RWL-A nrPDB Length = 426 Score = 51.6 bits (122), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 43/171 (25%), Positives = 72/171 (42%), Gaps = 26/171 (15%) Query: 294 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQM 353 E + ++ I G +TT + ++ + L +PD KL KA P Sbjct: 254 EYLGNVLLLIVGGNDTTRNSMTGGVLALHKNPDQFAKL----------KANPAL------ 297 Query: 354 EYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEK 413 ++ +V E +R + R D E+ G I KG V++ Y+ +RD + PE+ Sbjct: 298 --VETMVPEIIRWQTPLAHMRRTAIADSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEE 355 Query: 414 FLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS 464 F+ +R P + FG G C+G R A M +++ +L FS Sbjct: 356 FIIDRPR--------PRQHLSFGFGIHRCVGNRLAEMQLRILWEEILTRFS 398 >6F0B-A nrPDB Length = 395 Score = 51.2 bits (121), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 40/177 (22%), Positives = 78/177 (44%), Gaps = 28/177 (15%) Query: 288 KALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTY 347 K L+ E + ++ I GY+TT+S +S + A P+ + E P + P Sbjct: 216 KQLTFHETIGVILMLIVGGYDTTASTISLSLVSYALQPEKFSVVHEH-----PERIP--- 267 Query: 348 DTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPK 406 ++V E LR ++ + L R+ +DVE+ G+ + G +V+ +RD Sbjct: 268 ----------LLVEELLRYHTVSQLGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDES 317 Query: 407 YWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 + P++ F + + ++ FG GP C+G A + ++ A+ V++ Sbjct: 318 VFPNPDEL---DFDRPSVPHVG------FGYGPHQCVGQALARVELQEAIPAVIRRL 365 >1Q5D-A nrPDB Length = 419 Score = 51.2 bits (121), Expect = 9e-07, Method: Compositional matrix adjust. Identities = 81/352 (23%), Positives = 145/352 (41%), Gaps = 58/352 (16%) Query: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183 E+ R+R L++P+FTS + + I + D L+ +A +G+ DV Sbjct: 101 EDHARVRKLVNPSFTSRAIDLLRAEIQRTVDQLL-----DARSGQE----------EFDV 145 Query: 184 ITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPR 243 + + G+ + +++ E +K RF L + + P + + L V Sbjct: 146 VRDYAEGIPMRAISALLKVPAECDEKFRRFGSATARALGVGLVPRVDEETKTLVASV--T 203 Query: 244 EVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFI 303 E L + + + LE+ D L +++ ++ LS ELVA I Sbjct: 204 EGLALLHGVLDERRRNPLEN------DVLTMLLQAEADGSR-----LSTKELVALVGAII 252 Query: 304 FAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNET 363 AG +TT +++F + L P+ + ++ E P D VL+ + + Sbjct: 253 AAGTDTTIYLIAFAVLNLLRSPEALELVKAE-----PGLMRNALDEVLRFDNI------- 300 Query: 364 LRLFPIAMRLERVCKKDVEINGMFIPKG--VVVMIPSYALHRDPKYWTEPEKFLPERFSK 421 LR+ + R ++D+E G I KG V ++IPS AL RD ++ P+ F R Sbjct: 301 LRIGTV-----RFARQDLEYCGASIKKGEMVFLLIPS-AL-RDGTVFSRPDVFDVRR--- 350 Query: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQI 473 D +G GP C G+ A + ++A+ + + F KET + Sbjct: 351 ------DTSASLAYGRGPHVCPGVSLARLEAEIAVGTIFRRFPEMKLKETPV 396 >3TYW-A nrPDB Length = 417 Score = 51.2 bits (121), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 39/165 (23%), Positives = 78/165 (47%), Gaps = 32/165 (19%) Query: 301 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV 360 I I AG ETT+S+++ L P++ +L+++ D + V Sbjct: 245 ITINAGRETTTSMIALSTLLLLDRPELPAELRKDPD------------------LMPAAV 286 Query: 361 NETLRLFPIAMRLE-RVCKKDVEINGMFIPK--GVVVMIPSYALHRDPKYWTEPEKFLPE 417 +E LR+ +A + RV +D+E++G +P GV+ ++ + DP+ + +PE+ Sbjct: 287 DELLRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALL--AGANHDPEQFDDPERV--- 341 Query: 418 RFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQN 462 F + + ++ FG G C+G A + +++AL +L+ Sbjct: 342 DFHRTDNHHV------AFGYGVHQCVGQHLARLELEVALETLLRR 380 >4Z5Q-A nrPDB Length = 423 Score = 50.8 bits (120), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 44/210 (20%), Positives = 92/210 (43%), Gaps = 38/210 (18%) Query: 256 MKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315 +KE R E R D +I+++++ H L++ EL+ I + G+ETT+S +S Sbjct: 223 VKERRAEP----RDDLTSALIEARDA-----HDRLAEPELIGLCISILIGGFETTASEIS 273 Query: 316 FIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMR--L 373 ++ L ++ +L + +A+ V E LR P A Sbjct: 274 SFVHVLQQRRELWTRLCADPEAI------------------PAAVEELLRFVPFAANGIS 315 Query: 374 ERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYT 433 R +D+ + G+ + +G V++ + A++RD + ++ + +R + + Sbjct: 316 PRYALEDMTVGGVLVREGEPVIVDTSAVNRDGLVFDNADEVVIDRADNR---------HM 366 Query: 434 PFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 FG G +C+G A + ++ AL +++ Sbjct: 367 VFGHGAHHCLGAHLARVELQEALKALVEGM 396 >5LIV-A nrPDB Length = 450 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 38/162 (23%), Positives = 70/162 (43%), Gaps = 26/162 (16%) Query: 302 FIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVN 361 I GYETTS +++ ++ L HPD +++++ ++LP + Sbjct: 276 LILGGYETTSWLVANTIHALLAHPDTLARVRQD-PSLLP-----------------AAIE 317 Query: 362 ETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421 E +R P + + R+ ++DV ++ + G VV + A + D + PE + +R Sbjct: 318 EGMRWCPSSFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDR-KP 376 Query: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 N+ FG G C+G A M ++ L +L F Sbjct: 377 LPAANV-------FGGGAHFCVGAPLARMEARVGLQALLARF 411 >4TRI-A nrPDB Length = 407 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 46/208 (22%), Positives = 86/208 (41%), Gaps = 33/208 (15%) Query: 270 DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQ 329 D ++++S E E + +SD E+V ++++ + G ETT LS +L H D Sbjct: 203 DLFSVLVNS----EVEGQR-MSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHRDQWD 257 Query: 330 KLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIP 389 L ++D +LP + E LR + R D +G + Sbjct: 258 ALVADVD-LLPG-----------------AIEEMLRWTSPVKNMCRTLTADTVFHGTELR 299 Query: 390 KGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449 G +M+ + + D + +P+ F +R +P + FG G C+G + A Sbjct: 300 AGEKIMLMFESANFDESVFGDPDNFRIDR---------NPNSHVAFGFGTHFCLGNQLAR 350 Query: 450 MNMKLALIRVLQNF-SFKPCKETQIPLK 476 + ++L RVL+ + + +PL+ Sbjct: 351 LELRLMTERVLRRLPDLRLADDAPVPLR 378 >5XJN-A nrPDB Length = 455 Score = 50.4 bits (119), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 43/180 (23%), Positives = 77/180 (42%), Gaps = 26/180 (14%) Query: 282 KETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN 341 + + + ++D E+ + +FAG+ETT++++S L HP E+ A+L N Sbjct: 269 RAQQEGQEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHP-------EQWQAILEN 321 Query: 342 KAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYAL 401 + + V+E LR + R KD EI G+ I +G V++ + Sbjct: 322 P-----------KLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSA 370 Query: 402 HRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQ 461 +RD + E+F R + + + FG G C+G A + K+ L V + Sbjct: 371 NRDEARFENGEEFDISRANARE--------HLSFGFGIHYCLGNMLAKLQAKICLEEVTR 422 >5GWE-A nrPDB Length = 405 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 43/174 (24%), Positives = 75/174 (43%), Gaps = 26/174 (14%) Query: 288 KALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTY 347 + ++D E+ + +FAG+ETT++++S L HP E+ A+L N Sbjct: 225 QEITDHEIASLLYSLLFAGHETTTTLISNCFRVLLDHP-------EQWQAILENP----- 272 Query: 348 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKY 407 + + V+E LR + R KD EI G+ I +G V++ + +RD Sbjct: 273 ------KLIPAAVDEVLRYSGSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEAR 326 Query: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQ 461 + E+F R + + + FG G C+G A + K+ L V + Sbjct: 327 FENGEEFDISRANARE--------HLSFGFGIHYCLGNMLAKLQAKICLEEVTR 372 >5YHJ-A nrPDB Length = 413 Score = 50.1 bits (118), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 49/195 (25%), Positives = 82/195 (42%), Gaps = 22/195 (11%) Query: 294 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQM 353 E+VA ++ I S + F + L PDV+++++ V + Sbjct: 228 EVVAVEVLNILRPTVAISVYVLFTVLALHQFPDVKEQVER--------------GEVSKT 273 Query: 354 EYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEK 413 E+ V E R +P K D E +G P+G + ++ Y + D WTEP++ Sbjct: 274 EF----VQEVRRFYPFFPVAAARVKTDFEWDGYAFPEGTLTLLDLYGTNHDVSIWTEPDR 329 Query: 414 FLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQI 473 F P RF K K++ P+ + P G G + G R A ++ +A++ + K T Sbjct: 330 FDPSRF-KDWKES--PFNFIPQGGGDVD-FGHRCAGEHVTIAILAQVIELFTKEYAYTVP 385 Query: 474 PLKLSLGGLLQPEKP 488 P LS + P P Sbjct: 386 PQDLSYSFVDMPSLP 400 >3ABA-A nrPDB Length = 403 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 50/186 (26%), Positives = 76/186 (40%), Gaps = 32/186 (17%) Query: 290 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 349 + D+ L+ + + A ++TT+ ++ L PD Q L E +++ N Sbjct: 222 VDDMFLMNAAGTLLIAAHDTTACMIGLGTALLLDSPD-QLALLREDPSLVGN-------- 272 Query: 350 VLQMEYLDMVVNETLRLFPIAM-RLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYW 408 V E LR I ERV +DVE+ G+ I KG V+ A DP + Sbjct: 273 ---------AVEELLRYLTIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFV 323 Query: 409 TEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKL---ALIRVLQNFSF 465 EPE+F R P + FG G CIG + A + +++ L R L Sbjct: 324 EEPERFDITR---------RPAPHLAFGFGAHQCIGQQLARIELQIVFETLFRRLPGLRL 374 Query: 466 -KPCKE 470 KP +E Sbjct: 375 AKPVEE 380 >6F88-A nrPDB Length = 400 Score = 49.7 bits (117), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 38/162 (23%), Positives = 69/162 (42%), Gaps = 26/162 (16%) Query: 302 FIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVN 361 I GYETTS +++ ++ L HPD +++++ ++LP + Sbjct: 226 LILGGYETTSWLVANTIHALLAHPDTLARVRQD-PSLLP-----------------AAIE 267 Query: 362 ETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421 E +R P + R+ ++DV ++ + G VV + A + D + PE + +R Sbjct: 268 EGMRWCPSNFGVLRMVERDVRLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDR-KP 326 Query: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 N+ FG G C+G A M ++ L +L F Sbjct: 327 LPAANV-------FGGGAHFCVGAPLARMEARVGLQALLARF 361 >5H1Z-A nrPDB Length = 407 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 41/187 (21%), Positives = 74/187 (39%), Gaps = 32/187 (17%) Query: 270 DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQ 329 D + +MI S E + +E + I+ I G +TT + +S + Y L PD + Sbjct: 216 DLISMMIHSDAMAE------MDQMEFLGNLILLIVGGNDTTRNTMSAVAYGLDLFPDQRA 269 Query: 330 KLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIP 389 KL+ + P+ P T V E +R + R D E+ G I Sbjct: 270 KLEAD-----PSMIPNT-------------VQEIIRWQTPLAHMRRTATVDSELEGQQIK 311 Query: 390 KGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449 G + + + +RD + ++ + +R + + + FG G C+G R A Sbjct: 312 AGDKLALWYISANRDESVFENADRIIVDRPNARR--------HLAFGHGIHRCVGARLAE 363 Query: 450 MNMKLAL 456 + + + L Sbjct: 364 LQIAVLL 370 >4MM0-A nrPDB Length = 399 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 43/175 (24%), Positives = 75/175 (42%), Gaps = 28/175 (16%) Query: 290 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 349 L+D ++ + S+I + AGYE S+ L + L PD +L+ + +LP+ Sbjct: 221 LTDHDVRSLSLILLLAGYEPASNQLGSSVLTLLRFPDRLAELRRD-PGLLPS-------- 271 Query: 350 VLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYW 408 V E +R P L RV +DV I IP V+ + A + DP+ + Sbjct: 272 ---------AVEELMRYAPAGDGALFRVTLEDVTIGDTHIPANSAVLASTQAANWDPRRF 322 Query: 409 TEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 +P +R + +T G G C+G A + +++A+ +L+ F Sbjct: 323 DDPTGLRLDRPDNQ---------HTALGHGIHFCLGAALARVELQVAIGALLRRF 368 >2RFC-A nrPDB Length = 343 Score = 49.3 bits (116), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 43/171 (25%), Positives = 73/171 (42%), Gaps = 32/171 (18%) Query: 294 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQM 353 E + ++ I G ETT++++ ++ + +PD+ ID L N++ Sbjct: 177 EKIKYIMLLIIGGNETTTNLIGNMIRVIDENPDI-------IDDALKNRSG--------- 220 Query: 354 EYLDMVVNETLRLF-PIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPE 412 V ETLR + PI R +D IN I KG V++ + +RD ++ EP+ Sbjct: 221 -----FVEETLRYYSPIQFLPHRFAAEDSYINNKKIKKGDQVIVYLGSANRDETFFDEPD 275 Query: 413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 F R ++ FG G C+G A + +AL +L +F Sbjct: 276 LFKIGRRE----------MHLAFGIGIHMCLGAPLARLEASIALNDILNHF 316 >4YZR-A nrPDB Length = 405 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 53/223 (23%), Positives = 89/223 (39%), Gaps = 34/223 (15%) Query: 243 REVTNFLRKSVKRMKESRLEDTQ-KHRVDFLQLMIDSQNSKETESHKALSDLELVAQSII 301 RE+TN + K + D + K + D + ++ ++ E+ LS+ EL + + Sbjct: 183 RELTNQALREFKDYIAKLIHDRRIKPKDDLISKLVHAE-----ENGSKLSEKELYSMLFL 237 Query: 302 FIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVN 361 + AG ETT ++L L H +KL++ Q E + V Sbjct: 238 LVVAGLETTVNLLGSGTLALLQHKKECEKLKQ------------------QPEMIATAVE 279 Query: 362 ETLRLF-PIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS 420 E LR P+ M R +D G I +G ++ I + +RDP ++ PE Sbjct: 280 ELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEIL------ 333 Query: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 N P + FG G C+G A + +A +L+ F Sbjct: 334 ---NINRSPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRF 373 >1ODO-A nrPDB Length = 408 Score = 48.9 bits (115), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 80/340 (23%), Positives = 133/340 (39%), Gaps = 63/340 (18%) Query: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV-IT 185 ++LR L++P F++ ++ M P + LV L E G+PV L+ AY + + + Sbjct: 96 RKLRRLVAPAFSARRVDAMRPAVEAMVTGLVDRLA-ELPAGEPVDLRQEL-AYPLPIAVI 153 Query: 186 STSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREV 245 GV PQD + + L D + EVL+ + Sbjct: 154 GHLMGV-------PQD--RRDGFRALVDGVFDTTLDQAEAQANTARLYEVLDQLI----- 199 Query: 246 TNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA 305 + KR D L+I +++ E + + LS EL ++ I A Sbjct: 200 ------AAKRATPGD---------DMTSLLIAARDD-EGDGDR-LSPEELRDTLLLMISA 242 Query: 306 GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLR 365 GYETT +V+ ++ L T PD +++ ++ + D VV ETLR Sbjct: 243 GYETTVNVIDQAVHTLLTRPDQLALVRKG-----------------EVTWAD-VVEETLR 284 Query: 366 LFPIAMRLE-RVCKKDVEI-NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKN 423 P L R D+ + +G I +G ++ A +R P + + + F R K+ Sbjct: 285 HEPAVKHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHEDADTFDATRTVKE- 343 Query: 424 KDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 + FG G C+G A M + LAL + F Sbjct: 344 --------HLAFGHGVHFCLGAPLARMEVTLALESLFGRF 375 >5KYO-A nrPDB Length = 430 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 57/244 (23%), Positives = 98/244 (40%), Gaps = 43/244 (17%) Query: 261 LEDTQKHRVDFLQLMIDSQNSKETE-----------SHKALSDLELVAQSIIFIFAGYET 309 L+D K ++L+ +I+++ K E + L+D+E I + G +T Sbjct: 215 LDDVTKQFREYLRPVIEARRIKPGEDMISRMINGEVGGRPLTDIEAENICIQVLVGGLDT 274 Query: 310 TSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPI 369 ++L F LA +++ + A P+ +D + E R FP+ Sbjct: 275 VVNMLGFTFSHLAKDHALRRAI----------AADPSL--------IDDALLEFFRRFPV 316 Query: 370 AMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP 429 V + D E G+ + G +VM P+ + D +P +F R +K + Sbjct: 317 VSSAREVLR-DQEFEGVLLKAGDMVMAPTVVVAMDDARNEDPLEF---RLGRKARQ---- 368 Query: 430 YIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLSLGGLLQPEKP 488 ++ FG G C G A M MK+ L F+ E PL+ S G++ KP Sbjct: 369 --HSTFGKGSHTCPGAHLARMEMKVVLREWFARIPEFR--IEDDAPLRYS-NGIVGSVKP 423 Query: 489 VVLK 492 VL+ Sbjct: 424 FVLE 427 >1CPT-A nrPDB Length = 428 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 39/165 (23%), Positives = 69/165 (41%), Gaps = 27/165 (16%) Query: 290 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 349 + D + A + AG++TTSS + L+ +P+ Q L + A++P Sbjct: 252 IDDKYINAYYVAIATAGHDTTSSSSGGAIIGLSRNPE-QLALAKSDPALIPR-------- 302 Query: 350 VLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWT 409 +V+E +R R D E+ G I +G +M+ + +RD + ++ Sbjct: 303 ---------LVDEAVRWTAPVKSFMRTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFS 353 Query: 410 EPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKL 454 P++F RF P + FG G C+G A + MK+ Sbjct: 354 NPDEFDITRF---------PNRHLGFGWGAHMCLGQHLAKLEMKI 389 >5Y1I-A nrPDB Length = 403 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 55/269 (20%), Positives = 114/269 (42%), Gaps = 49/269 (18%) Query: 230 IPILEVLNICVFPREVTNFLRKSVKRM--KESRLEDTQKHRVD---FLQLMIDSQNSKET 284 +P+ + + P E FL+++ M +++ D QK + +L+ ++ ++ Sbjct: 147 VPVRVICEMLGVPYEDREFLQQNNNAMIYRDTAQGDAQKAAIAQAMYLKELVGTKLGDRG 206 Query: 285 ESHKALSDLELVAQS------------IIFIFAGYETTSSVLSFIMYELATHPDVQQKLQ 332 + LSDL + ++ ++ + AG+ETT+++++ L +P+ +++ Sbjct: 207 DD--ILSDLAVQVEAGEITQDDAAGIGMMLLGAGHETTANMIALGTLALLENPEQLAEVR 264 Query: 333 EEID-AVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAM-RLERVCKKDVEINGMFIPK 390 + D V+ N V E LR IA + R+ +D+EI G+ I Sbjct: 265 DSDDPKVIVN-----------------TVEELLRYLTIAQDTVRRIAAEDIEIGGVVIKA 307 Query: 391 GVVVMIPSYALHRDPKYWTE-PEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449 G ++ P A + DP + E P++ R + + + FG G C+G A Sbjct: 308 GEGIVFPLNAANWDPDLYPEAPDRLDIHRANARR--------HLAFGYGVHQCLGATLAR 359 Query: 450 MNMKLALIRVLQNFSFKPCKET--QIPLK 476 + +++ +L+ T +IP K Sbjct: 360 VELQIVYSTLLRRIPTLALAGTLDEIPFK 388 >3WEC-A nrPDB Length = 419 Score = 47.4 bits (111), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 76/374 (20%), Positives = 135/374 (36%), Gaps = 90/374 (24%) Query: 125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVI 184 E RLR L+S FT M I+ VR+L + + +V + ++V+ Sbjct: 107 EHTRLRGLVSDAFTRSTTTSMDDIVLSAASSAVRHLEHCTDA-----VSEVAEPFPVEVL 161 Query: 185 TSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPRE 244 +S L P K RF + F IP Sbjct: 162 SSI--------LGIPD-------KDRGRFSEWSNLVAGVLDINFAIP------------- 193 Query: 245 VTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKE---------TESHKALSDLEL 295 K V + + +E++ +D+ + + S N+ E + LS E+ Sbjct: 194 ------KEVADRRSAAIEES----IDYFRTLATSGNAPEGLVRRLSEVSHGGDQLSVDEI 243 Query: 296 VAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEY 355 A ++ AG ETTS+ + ++ + H D +++ +A P ++ Sbjct: 244 AATCLLITVAGQETTSNTIGNMLITFSRHADQFEQV----------RANP--------QF 285 Query: 356 LDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFL 415 ++ V E LR P A R+ +D E++G I KG VM+ + +R+ + Sbjct: 286 IENAVAEVLRFEPPAHEAGRIALEDCEVSGANITKGDAVMVLLASGNREAVERGDT---- 341 Query: 416 PERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFA---------LMNMKLALIRVLQNFSFK 466 FS D +G G +C+G A ++ + I V + ++K Sbjct: 342 ---FSVTRPD----VSSLSYGRGIHHCLGSALANSMLQHFLRELSQRYRSIEVAEPINYK 394 Query: 467 PCKETQIPLKLSLG 480 P + P LS+ Sbjct: 395 PGMGLRGPETLSVA 408 >5DE9-A nrPDB Length = 410 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 33/106 (31%), Positives = 50/106 (47%), Gaps = 11/106 (10%) Query: 359 VVNETLRLFPI--AMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLP 416 ++E LR P A+ L R+ +DVEI G+ I G V + A +RDP+ + +P++ Sbjct: 277 AIDELLRWIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDF 336 Query: 417 ERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQN 462 ER P + FG GP C G A + +L + VL Sbjct: 337 ER---------SPNPHVSFGFGPHYCPGGMLARLESELLVDAVLDR 373 >5IT1-A nrPDB Length = 399 Score = 47.0 bits (110), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 45/186 (24%), Positives = 75/186 (40%), Gaps = 32/186 (17%) Query: 290 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 349 + D+ L+ + + A ++TT+ ++ L PD LQ++ P+ Sbjct: 222 IDDMFLMNAAGTLLIAAHDTTACMIGLGTALLLDRPDQLALLQKD----------PSL-- 269 Query: 350 VLQMEYLDMVVNETLRLFPIAM-RLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYW 408 + V E LR I ERV +D EI G+ I KG V+ + DP + Sbjct: 270 ------IGNAVEELLRYLTIGQFGAERVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFV 323 Query: 409 TEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS---- 464 +PE+F R P + FG G CIG + A + +++ + + F Sbjct: 324 EDPERFDITR---------RPAPHLAFGFGAHQCIGQQLARIELQIVFGTLFRRFPTLRL 374 Query: 465 FKPCKE 470 KP +E Sbjct: 375 AKPVEE 380 >6G71-A nrPDB Length = 405 Score = 46.6 bits (109), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 34/118 (28%), Positives = 57/118 (48%), Gaps = 15/118 (12%) Query: 359 VVNETLR-LFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPE 417 V E++R + PI M + R D E++G FIP+G + + + +RD W++P++F E Sbjct: 272 VFEESIRWVAPIGM-VPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWSDPDRFDIE 330 Query: 418 RFSKKNKDNIDPYIYTPFGSGPRNCIG---MRFALMNMKL-ALIRVLQNFSFKPCKET 471 R S+ + FG G C+G R + ++ L AL L+ P +E Sbjct: 331 RGSEA---------HLAFGKGVHVCLGAWAARSQVADVGLPALFSRLKGLRLDPNQEA 379 >5LIE-A nrPDB Length = 414 Score = 46.6 bits (109), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 41/176 (23%), Positives = 70/176 (39%), Gaps = 27/176 (15%) Query: 289 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYD 348 ALSD EL + AG ETT + ++ + LA +PD Q L+ + Sbjct: 237 ALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSD-------------- 282 Query: 349 TVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYW 408 E L + E +R + R + V + G I G V++ + +RDP + Sbjct: 283 ----FELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVF 338 Query: 409 TEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS 464 ++F ++K P + FG G C+G A + +++ +L F Sbjct: 339 DRADEF---DITRK------PNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFG 385 >4PWV-A nrPDB Length = 446 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 40/154 (25%), Positives = 64/154 (41%), Gaps = 18/154 (11%) Query: 356 LDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFL 415 L+ E LR AM R D+E++G I G VV + + + +RD + + +P F Sbjct: 303 LESATEEVLRWATPAMHFGRRAVTDMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAFD 362 Query: 416 PERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS--FKPCKETQI 473 R P + FG GP C+G + AL+ L+ ++ F+ E Q Sbjct: 363 LNR---------SPNKHITFGYGPHFCLGAYLGRAEVH-ALLDALRTYTTGFEITGEPQR 412 Query: 474 PLKLSLGGL------LQPEKPVVLKVESRDGTVS 501 L GL +QP + + +S +G S Sbjct: 413 IHSNFLTGLSRLPVRIQPNEAAIAAYDSDNGVRS 446 >5HIW-A nrPDB Length = 398 Score = 46.2 bits (108), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 38/164 (23%), Positives = 64/164 (39%), Gaps = 27/164 (16%) Query: 300 IIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMV 359 + I YETTS +L+ ++ L HPD +L++ Q L Sbjct: 223 LTLILGSYETTSWMLANLLVALLAHPDAMNQLRQ------------------QPSLLPQA 264 Query: 360 VNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERF 419 + E+ R A + R +++ I G + G ++ + A H D + + PE F R Sbjct: 265 IEESTRWCSSAAGIVRFVEREATIGGETLAAGTILYLSLIARHYDEEIYPRPETFDIHR- 323 Query: 420 SKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 P FG G C+G A M ++ + +L+ F Sbjct: 324 --------RPVGMLNFGGGLHYCVGAPLARMEARVGVSLLLERF 359 >5M0P-A nrPDB Length = 428 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 31/125 (24%), Positives = 50/125 (40%), Gaps = 21/125 (16%) Query: 314 LSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRL 373 +SF ++ + +P ++K++ E D Y E R +P L Sbjct: 260 VSFGLHAMNENPITREKIKSEPD------------------YAYKFAQEVRRYYPFVPFL 301 Query: 374 ERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYT 433 K D++ G+ IP GV + + Y D W +P +F PERF + P+ Sbjct: 302 PGKAKVDIDFQGVTIPAGVGLALDVYGTTHDESLWDDPNEFRPERFETWDG---SPFDLI 358 Query: 434 PFGSG 438 P G G Sbjct: 359 PQGGG 363 >1UED-A nrPDB Length = 406 Score = 45.1 bits (105), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 74/348 (21%), Positives = 123/348 (35%), Gaps = 69/348 (19%) Query: 118 ISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTL-KDVF 176 IS + E RLR +L+P FT +++ M P I D + L E + L D Sbjct: 97 ISTYDPPEHTRLRKMLTPEFTVRRIRRMEPAIQSLIDDRLDLLEAEGPSADLQGLFADPV 156 Query: 177 GAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVL 236 GA+++ + L P+D E +++ R L + Sbjct: 157 GAHAL-----------CELLGIPRDDQREFVRRIRRNADLSRGLKA-----------RAA 194 Query: 237 NICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELV 296 + F R + N L + + L +++ ++D EL Sbjct: 195 DSAAFNRYLDNLLARQRADPDDG-----------LLGMIVRDHGDN-------VTDEELK 236 Query: 297 AQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYL 356 I G ET + ++ F + L +P + L E P KA Sbjct: 237 GLCTALILGGVETVAGMIGFGVLALLDNPGQIELLFES-----PEKA------------- 278 Query: 357 DMVVNETLR-LFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFL 415 + VVNE +R L P+ R+ KDV I+G I G V+ +RD +P+ Sbjct: 279 ERVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDPDVLD 338 Query: 416 PERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 R + + FG G C+G A +++A + + F Sbjct: 339 ANRAAVSD---------VGFGHGIHYCVGAALARSMLRMAYQTLWRRF 377 >2WM5-A nrPDB Length = 435 Score = 45.1 bits (105), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 40/194 (20%), Positives = 80/194 (41%), Gaps = 28/194 (14%) Query: 264 TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELAT 323 + RV+ + S E + + LS E+ + I+ + AG ETT + ++ + L+ Sbjct: 234 AEDRRVNHHDDLTSSLVEAEVDGER-LSSREIASFFILLVVAGNETTRNAITHGVLALSR 292 Query: 324 HPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383 +P+ + + + D + P V E +R + + R +D+E+ Sbjct: 293 YPEQRDRWWSDFDGLAPT-----------------AVEEIVRWASPVVYMRRTLTQDIEL 335 Query: 384 NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN-C 442 G + G V + + +RD + +P F R N +P++ FG G + C Sbjct: 336 RGTKMAAGDKVSLWYCSANRDESKFADPWTFDLAR-------NPNPHL--GFGGGGAHFC 386 Query: 443 IGMRFALMNMKLAL 456 +G A +++A Sbjct: 387 LGANLARREIRVAF 400 >2RCM-A nrPDB Length = 495 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 41/150 (27%), Positives = 65/150 (43%), Gaps = 14/150 (9%) Query: 327 VQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI-- 383 V +L EEI +V+ N T + +ME VV E LR P KKD+ I Sbjct: 317 VHNRLAEEIRSVIKSNGGELTMGAIEKMELTKSVVYECLRFEPPVTAQYGRAKKDLVIES 376 Query: 384 -NGMFIPKGVVVMIPSYALH-RDPKYWTEPEKFLPERFSKKNKDNI--------DPYIYT 433 + F K ++ L RDPK + ++F+PERF + + + P T Sbjct: 377 HDAAFKVKAGEMLYGYQPLATRDPKIFDRADEFVPERFVGEEGEKLLRHVLWSNGPETET 436 Query: 434 PFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 P G + C G F ++ +L +I + + + Sbjct: 437 P-TVGNKQCAGKDFVVLVARLFVIEIFRRY 465 >2FR7-A nrPDB Length = 412 Score = 44.7 bits (104), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 41/183 (22%), Positives = 80/183 (43%), Gaps = 30/183 (16%) Query: 302 FIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVN 361 + AG +TT + ++ +Y LA PD +L+ + P+ A ++ ++ E Sbjct: 248 LLSAGLDTTVNGIAAAVYCLARFPDEFARLRAD-----PSLARNAFEEAVRFES------ 296 Query: 362 ETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421 P+ R +DVE+ G I +G V++ + +RDP+ W +P+++ ++ Sbjct: 297 ------PVQTFF-RTTTRDVELAGATIGEGEKVLMFLGSANRDPRRWDDPDRY---DITR 346 Query: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGG 481 K ++ FGSG C+G A + ++ L + + + E PLK Sbjct: 347 KTSGHVG------FGSGVHMCVGQLVARLEGEVVLAALARKVA---AIEIAGPLKRRFNN 397 Query: 482 LLQ 484 L+ Sbjct: 398 TLR 400 >6HQD-A nrPDB Length = 420 Score = 44.3 bits (103), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 45/195 (23%), Positives = 79/195 (40%), Gaps = 28/195 (14%) Query: 288 KALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTY 347 + L+ + + + I G +TT S +S +P +E D V N+A Sbjct: 242 QDLTPTDFLGTLALLIVGGNDTTRSSMSGSAMACHLYP-------QEFDKVRNNRA---- 290 Query: 348 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKY 407 L V+ E +R + R +DVE G I KG V++ + +RD + Sbjct: 291 -------LLASVIPEVVRWQTPIAHMRRTALEDVEFRGKQIRKGDKVVMWYLSGNRDDEV 343 Query: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS-FK 466 P F+ +R ++ + FG G C+G R A + +K+ + + +S + Sbjct: 344 IDRPMDFIADRPRARH--------HLSFGFGIHRCLGNRLAELQLKILWEEMCERYSRIE 395 Query: 467 PCKE-TQIPLKLSLG 480 C E ++P L G Sbjct: 396 VCGEPVRVPSNLVHG 410 >3A1L-A nrPDB Length = 425 Score = 43.9 bits (102), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 37/169 (21%), Positives = 66/169 (39%), Gaps = 27/169 (15%) Query: 295 LVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQME 354 +V + + AG+ETT++ L+ + L H DV +L+ P P Sbjct: 244 IVGTCVHLLTAGHETTTNFLAKAVLTLRAHRDVLDELR-----TTPESTP---------- 288 Query: 355 YLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKF 414 V E +R P + R +D+ + IP+G V+ + +RDP + +P+ Sbjct: 289 ---AAVEELMRYDPPVQAVTRWAYEDIRLGDHDIPRGSRVVALLGSANRDPARFPDPDVL 345 Query: 415 LPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 R +++ FG G C+G A ++ L +L Sbjct: 346 DVHRAAERQ---------VGFGLGIHYCLGATLARAEAEIGLRALLDGI 385 >6CVC-A nrPDB Length = 433 Score = 43.5 bits (101), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 40/190 (21%), Positives = 74/190 (38%), Gaps = 32/190 (16%) Query: 266 KHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHP 325 H D +++++ E LS E+ I+ + AG ETT + +S M L+ +P Sbjct: 237 NHHGDLTTSLVEAEVDGER-----LSSSEIAMFFILLVVAGNETTRNAISHGMLALSRYP 291 Query: 326 DVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEING 385 D + K + D + V E +R + + R +DV++ G Sbjct: 292 DERAKWWSDFDGLAAT-----------------AVEEIVRWASPVVYMRRTLSQDVDLRG 334 Query: 386 MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN-CIG 444 + G V + + +RD + + +P F R +P FG G + C+G Sbjct: 335 TKMAAGDKVTLWYCSANRDEEKFADPWTFDVTR---------NPNPQVGFGGGGAHFCLG 385 Query: 445 MRFALMNMKL 454 A +++ Sbjct: 386 ANLARREIRV 395 >2WIY-A nrPDB Length = 394 Score = 43.1 bits (100), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 25/86 (29%), Positives = 42/86 (48%), Gaps = 7/86 (8%) Query: 359 VVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 418 ++NE +R+ P + R +DVEI G+ I G + A +RDP+ + +P+ F R Sbjct: 269 IINEMVRMDPPQLSFLRFPTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHTR 328 Query: 419 FSKKNKDNIDPYIYTPFGSGPRNCIG 444 +++ FG GP +C G Sbjct: 329 PPAASRN-------LSFGLGPHSCAG 347 >4XE3-A nrPDB Length = 407 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 44/203 (21%), Positives = 90/203 (44%), Gaps = 29/203 (14%) Query: 284 TESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKA 343 T++ L+ E+V + + AG+ET+ + ++ +++ L T ++K E + Sbjct: 223 TDNDDHLTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLT----ERKRYESL-------- 270 Query: 344 PPTYDTVLQMEYLDMVVNETLRLFPI--AMRLERVCKKDVEINGMFIPKGVVVMIPSYAL 401 V + V E LR P+ A RV +DVE++ + + G ++ + Sbjct: 271 ------VADPALVPAAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVRAGEPCVVHFASA 324 Query: 402 HRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQ 461 +RD + + ++ F ++ +P+I FG G +CIG + + ++ AL +++ Sbjct: 325 NRDEEVFDHADEL---DFHRER----NPHIA--FGHGAHHCIGAQLGRLELQEALSALVR 375 Query: 462 NFSFKPCKETQIPLKLSLGGLLQ 484 F E LK G L++ Sbjct: 376 RFPTLDLAEPVAGLKWKQGMLIR 398 >6M7L-A nrPDB Length = 404 Score = 42.7 bits (99), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 46/187 (24%), Positives = 72/187 (38%), Gaps = 36/187 (19%) Query: 290 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 349 +SD EL + + + E T S L+ L HP+ L+E Sbjct: 229 ISDEELAGLCAVVMNSSVEQTESCLAAGTLLLLEHPEQFALLRE---------------- 272 Query: 350 VLQMEYLDMVVNETLRLFPIAMRLE-RVCKKDVEINGMFIPKGVVVMIPSYALHR-DPKY 407 + E + V E +R + L+ R +DVEI G I KG V A +R DP Sbjct: 273 --RPELGEQAVEEIVRYLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAANRADPAL 330 Query: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467 + F K++ + FG G +C+G A M +++A ++ F P Sbjct: 331 ---------DGFDITRKESR----HVAFGHGIHHCLGAPLARMELRIAFTTLVSRF---P 374 Query: 468 CKETQIP 474 T +P Sbjct: 375 SLRTAVP 381 >5Z9I-A nrPDB Length = 398 Score = 42.4 bits (98), Expect = 4e-04, Method: Compositional matrix adjust. Identities = 25/98 (25%), Positives = 46/98 (46%), Gaps = 9/98 (9%) Query: 359 VVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 418 ++ E++R + R +VE+ G IPK ++++ + A +RD + + +P+ F R Sbjct: 273 LLEESMRYMSPICGVGRATNSEVEVAGTVIPKDQLLLVWTGAANRDERQFEKPDVFDAGR 332 Query: 419 FSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLAL 456 P + FG G C+G + A M K A+ Sbjct: 333 ---------SPNAHLGFGRGIHFCLGRQLARMESKAAV 361 >4DO1-A nrPDB Length = 410 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 36/155 (23%), Positives = 65/155 (41%), Gaps = 27/155 (17%) Query: 302 FIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVN 361 + AG +TT + + +Y LA P Q+L+ D L A Sbjct: 246 LLSAGLDTTVNGIGAAVYCLARFPGELQRLRS--DPTLARNA----------------FE 287 Query: 362 ETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421 E +R R ++VE+ G I +G V++ + +RDP+ W++P+ + ++ Sbjct: 288 EAVRFESPVQTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLY---DITR 344 Query: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLAL 456 K ++ FGSG C+G A + ++ L Sbjct: 345 KTSGHVG------FGSGVHMCVGQLVARLEGEVML 373 >2NZA-A nrPDB Length = 413 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 37/158 (23%), Positives = 68/158 (43%), Gaps = 25/158 (15%) Query: 306 GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLR 365 G E + + ++Y L T ++ +++E P T L E L + + T Sbjct: 245 GGEAVTHNVGQMLYLLLTRRELMARMRER---------PGARGTALD-ELLRWISHRT-- 292 Query: 366 LFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKD 425 ++ L R+ +DVE++G I G V + A +RDP + +P++ +R Sbjct: 293 ----SVGLARIALEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDPDRIDLDR------- 341 Query: 426 NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 DP + +G+G C G A M +L + +L+ Sbjct: 342 --DPNPHLAYGNGHHFCTGAVLARMQTELLVDTLLERL 377 >6GMF-A nrPDB Length = 397 Score = 42.4 bits (98), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 51/214 (23%), Positives = 84/214 (39%), Gaps = 42/214 (19%) Query: 281 SKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLP 340 + E + K L+ E+++ + + AG ETT+S++ + L HP+ Q ++ V Sbjct: 210 AAEVDGEK-LTAGEVLSFANTLLIAGNETTTSLIGNALVALTDHPEQLAAAQADLSLV-- 266 Query: 341 NKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYA 400 VV E LR A + R DVEI IP VV+ + Sbjct: 267 ----------------PAVVEEVLRYESPAQCIFRQTMTDVEIGDERIPARSVVLPLLAS 310 Query: 401 LHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLAL---- 456 +RD + +P++F R +K + FG CIG A + K+ L Sbjct: 311 ANRDESRFPDPDRFDIHRDTKG---------HLAFGLDIHFCIGAPLARLEAKVMLEVLL 361 Query: 457 ------IRVLQNFSFKPC----KETQIPLKLSLG 480 RV Q S+ P + +PL+ ++ Sbjct: 362 ARLGDIQRVSQEVSWSPSFFIRSPSTLPLRATVA 395 >5DQN-A nrPDB Length = 426 Score = 42.0 bits (97), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 52/218 (23%), Positives = 83/218 (38%), Gaps = 38/218 (17%) Query: 290 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 349 LSD E ++ AG ETT + ++ M A +PD + Sbjct: 236 LSDDEFGFFVVMLAVAGNETTRNSITHGMIAFAQNPDQWE-------------------- 275 Query: 350 VLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWT 409 + + E + +E +R +R +DVE+ G+ I KG V++ + + D + + Sbjct: 276 LYKKERPETAADEIVRWATPVSAFQRTALEDVELGGVQIKKGQRVVMSYRSANFDEEVFE 335 Query: 410 EPEKFLPERFSKKNKDNI--DPYIYTPF-GSGPRNCIGMRFALMNMKLALIRVLQNF-SF 465 +P F NI P + F G+G CIG A M + L + N Sbjct: 336 DPHTF-----------NILRSPNPHVGFGGTGAHYCIGANLARMTINLIFNAIADNMPDL 384 Query: 466 KPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGA 503 KP P +L G L + V + +VSGA Sbjct: 385 KPIG---APERLKSGWLNGIKHWQVDYTGAGKASVSGA 419 >3B98-A nrPDB Length = 475 Score = 42.0 bits (97), Expect = 7e-04, Method: Compositional matrix adjust. Identities = 53/206 (25%), Positives = 87/206 (42%), Gaps = 35/206 (16%) Query: 316 FIMYELATHPDVQQKLQEEIDAVLP------NKAPPTYDTVLQMEYLDMVVNETLRLFPI 369 ++M L THP+ + ++EEI K P +D+VL ETLRL Sbjct: 275 WVMGYLLTHPEALRAVREEIQGGKHLRLEERQKNTPVFDSVLW---------ETLRLTAA 325 Query: 370 AMRLERVCKKDVEI---NGM--FIPKG-VVVMIPSYALHRDPKYWTEPEKFLPERFSKKN 423 A+ + R +D +I NG + +G + + P + DP+ +PE F +RF + Sbjct: 326 AL-ITRDVTQDKKICLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPEMFQFDRFLNAD 384 Query: 424 KDNID---------PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPC-KETQI 473 + Y P+G+ C G FA+ +K + +L F + C K + Sbjct: 385 RTEKKDFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKELVFTILTRFDVELCDKNATV 444 Query: 474 PL--KLSLG-GLLQPEKPVVLKVESR 496 PL G G+LQP + ++ R Sbjct: 445 PLVDPSRYGFGILQPAGDLEIRYRIR 470 >1LG9-A nrPDB Length = 398 Score = 40.8 bits (94), Expect = 0.001, Method: Compositional matrix adjust. Identities = 40/199 (20%), Positives = 78/199 (39%), Gaps = 32/199 (16%) Query: 291 SDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTV 350 +D EL + + AG + S ++ + + HP E+IDA ++ Sbjct: 222 TDEELRGFCVQVMLAGDDNISGMIGLGVLAMLRHP-------EQIDAFRGDE-------- 266 Query: 351 LQMEYLDMVVNETLRLFPIAMR-LERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWT 409 + V+E +R + R+ ++D+ + G I KG V+ A +RDP Sbjct: 267 ---QSAQRAVDELIRYLTVPYSPTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPALAP 323 Query: 410 EPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS----F 465 + ++ R +P + FG G +C+G A + ++ + + F Sbjct: 324 DVDRLDVTR---------EPIPHVAFGHGVHHCLGAALARLELRTVFTELWRRFPALRLA 374 Query: 466 KPCKETQIPLKLSLGGLLQ 484 P ++T+ L GL + Sbjct: 375 DPAQDTEFRLTTPAYGLTE 393 >5L1U-A nrPDB Length = 401 Score = 40.4 bits (93), Expect = 0.002, Method: Compositional matrix adjust. Identities = 40/180 (22%), Positives = 67/180 (37%), Gaps = 22/180 (12%) Query: 284 TESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKA 343 E ALSD ++ + GYETT + L +P + +L E+ P A Sbjct: 214 AEKDGALSDADIAHLGNAVLLFGYETTIVRIDLGTLLLLRNPVQRAQLAED-----PGLA 268 Query: 344 PPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHR 403 P + +L++ N L P R D+ + I G VM+ A + Sbjct: 269 PAAVEEILRLGVGGKGSNA---LIP------RYAHGDITVGETVIRTGDAVMLAIGAANY 319 Query: 404 DPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 D + + + F + + P + FG G R+CIG A + + R+ + Sbjct: 320 DDRAFPDGGLF--------DLTRVRPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRL 371 >2IAG-A nrPDB Length = 482 Score = 40.0 bits (92), Expect = 0.003, Method: Compositional matrix adjust. Identities = 50/200 (25%), Positives = 88/200 (44%), Gaps = 31/200 (15%) Query: 325 PDVQQKLQEEIDAVLPNKAPPTYDTVL-------QMEYLDMVVNETLRLFP-------IA 370 P+ ++ E++++L P T LD V++E+LRL + Sbjct: 281 PEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVV 340 Query: 371 MRLERVCKKDVEINGMFIPKG-VVVMIPSYALHRDPKYWTEPEKFLPERF------SKKN 423 + L E N + +G +++ P + RDP+ +T+PE F RF KK+ Sbjct: 341 VDLAMPMADGREFN---LRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKD 397 Query: 424 --KDNIDPYIYT-PFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCK-ETQIP---LK 476 KD Y P+G+G +C+G +A+ ++K + VL + + + +IP L Sbjct: 398 FYKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLS 457 Query: 477 LSLGGLLQPEKPVVLKVESR 496 GL+QPE V ++ R Sbjct: 458 RYGFGLMQPEHDVPVRYRIR 477 >3OO3-A nrPDB Length = 384 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 44/180 (24%), Positives = 66/180 (36%), Gaps = 33/180 (18%) Query: 285 ESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAP 344 E +SD EL + + E ++ L+ + L THPD L+E Sbjct: 206 EHGAEISDEELAGLAEGNLIMAAEQMAAQLAVAVLLLVTHPDQMALLRE----------- 254 Query: 345 PTYDTVLQMEYLDMVVNETLRLFPIAMR-LERVCKKDVEINGMFIPKGVVVMIPSYALHR 403 + E +D E LR I RV DV + G I G V+ A +R Sbjct: 255 -------KPELIDSATEEVLRHASIVEAPAPRVALADVRMAGRDIHAGDVLTCSMLATNR 307 Query: 404 DPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 P +RF + + FG G +CIG A + +++AL V+ F Sbjct: 308 APG----------DRFDITREK----ATHMAFGHGIHHCIGAPLARLQLRVALPAVVGRF 353 >3IVY-A nrPDB Length = 433 Score = 38.9 bits (89), Expect = 0.005, Method: Compositional matrix adjust. Identities = 50/194 (25%), Positives = 79/194 (40%), Gaps = 32/194 (16%) Query: 290 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 349 LSD E ++ AG ETT + ++ M A HPD Q +L ++ V P A Sbjct: 253 LSDDEFGFFVVMLAVAGNETTRNSITQGMMAFAEHPD-QWELYKK---VRPETA------ 302 Query: 350 VLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWT 409 +E +R +R +D E++G+ I KG V++ + + D + + Sbjct: 303 ----------ADEIVRWATPVTAFQRTALRDYELSGVQIKKGQRVVMFYRSANFDEEVFQ 352 Query: 410 EPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF-SFKPC 468 +P F R N +P++ G+G CIG A M + L V + KP Sbjct: 353 DPFTFNILR-------NPNPHVGFG-GTGAHYCIGANLARMTINLIFNAVADHMPDLKPI 404 Query: 469 KETQIPLKLSLGGL 482 P +L G L Sbjct: 405 S---APERLRSGWL 415 >5OMS-A nrPDB Length = 409 Score = 38.9 bits (89), Expect = 0.006, Method: Compositional matrix adjust. Identities = 28/99 (28%), Positives = 43/99 (43%), Gaps = 10/99 (10%) Query: 359 VVNETLRLF-PIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPE 417 + E LR PI R+ K V I G+ +P G VM+ + + D + P ++ Sbjct: 283 AIAEGLRWTSPIWSATARISTKPVTIAGVDLPAGTPVMLSYGSANHDTGKYEAPSQYDLH 342 Query: 418 RFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLAL 456 R P + FG+G C G+ FA M++AL Sbjct: 343 R---------PPLPHLAFGAGNHACAGIYFANHVMRIAL 372 >2UUQ-A nrPDB Length = 414 Score = 38.5 bits (88), Expect = 0.007, Method: Compositional matrix adjust. Identities = 42/181 (23%), Positives = 71/181 (39%), Gaps = 26/181 (14%) Query: 293 LELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQ 352 L ++A + + G +T + +L M L PD ++ L ++ + + P+ Sbjct: 238 LSILAFTFTMVTGGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEGI-PD----------- 285 Query: 353 MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPE 412 V E LRL L R +DV I IP G V++ + +RD + + Sbjct: 286 ------AVEELLRLTSPVQGLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDA 339 Query: 413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ 472 L +N I T F G +C+G A M ++AL +L E++ Sbjct: 340 AELDVTRCPRN-------ILT-FSHGAHHCLGAAAARMQCRVALTELLARCPDFEVAESR 391 Query: 473 I 473 I Sbjct: 392 I 392 >4C9K-A nrPDB Length = 421 Score = 38.1 bits (87), Expect = 0.009, Method: Compositional matrix adjust. Identities = 39/172 (22%), Positives = 72/172 (41%), Gaps = 30/172 (17%) Query: 308 ETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF 367 +T + L F+M L+ HP+ +++ E P K L V E R F Sbjct: 259 DTVVNFLGFMMIYLSRHPETVAEMRRE-----PLK-------------LQRGVEELFRRF 300 Query: 368 PIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHR-DPKYWTEPEKFLPERFSKKNKDN 426 + R D+E +G + +G ++++P+ ALH D ++ +P + S+++ Sbjct: 301 AVVSDA-RYVVSDMEFHGTMLKEGDLILLPT-ALHGLDDRHHDDP---MTVDLSRRD--- 352 Query: 427 IDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS 478 ++ F GP C GM A + + + L L K+ +P+ S Sbjct: 353 ---VTHSTFAQGPHRCAGMHLARLEVTVMLQEWLARIPEFRLKDRAVPIYHS 401 >2X9P-A nrPDB Length = 404 Score = 38.1 bits (87), Expect = 0.009, Method: Compositional matrix adjust. Identities = 49/236 (20%), Positives = 92/236 (38%), Gaps = 57/236 (24%) Query: 270 DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQ 329 D + + D + +++ +H A+ +FAG ++ +S++ + LA HPD + Sbjct: 216 DIISRLNDGELTEDRVAHLAMG----------LLFAGLDSVASIMDNGVVLLAAHPDQRA 265 Query: 330 KLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRL--ERVCKKDVEINGMF 387 + D + V E LR + R +D+E G+ Sbjct: 266 AALADPD------------------VMARAVEEVLRTARAGGSVLPPRYASEDMEFGGVT 307 Query: 388 IPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRF 447 I G +V+ + D + +T PE+F R P + FG G +CIG Sbjct: 308 IRAGDLVLFDLGLPNFDERAFTGPEEFDAAR---------TPNPHLTFGHGIWHCIGAPL 358 Query: 448 ALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGA 503 A + ++ ++ T++P L+PE PV ++ ++G +SG Sbjct: 359 ARLELRTMFTKLF----------TRLP-------ELRPELPVE-QLRLKEGQLSGG 396 >2IJ7-A nrPDB Length = 396 Score = 37.7 bits (86), Expect = 0.011, Method: Compositional matrix adjust. Identities = 39/188 (20%), Positives = 74/188 (39%), Gaps = 31/188 (16%) Query: 274 LMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQE 333 LM + ++ ++ +SD + F AG +T S L+ + L P ++ L E Sbjct: 202 LMGELSRLRKDPAYSHVSDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHE 261 Query: 334 EIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL-FPIAMRLERVCKKDVEINGMFIPKGV 392 + E + V E LR+ A L R+ D+++ + + KG Sbjct: 262 ------------------KPELIPAGVEELLRINLSFADGLPRLATADIQVGDVLVRKGE 303 Query: 393 VVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSG----PRNCIGMRFA 448 +V++ + DP+++ P D +P + FG G P + +G R A Sbjct: 304 LVLVLLEGANFDPEHFPNPGSI--------ELDRPNPTSHLAFGRGQHFCPGSALGRRHA 355 Query: 449 LMNMKLAL 456 + ++ L Sbjct: 356 QIGIEALL 363 >5D3U-A nrPDB Length = 427 Score = 37.4 bits (85), Expect = 0.014, Method: Compositional matrix adjust. Identities = 26/108 (24%), Positives = 43/108 (39%), Gaps = 8/108 (7%) Query: 356 LDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFL 415 +D NE LR RV KDVE+ G+ I G + + + +RD + P F Sbjct: 300 VDNTANEVLRYNASNQFTWRVAAKDVEMGGVRIEAGQTLALFLGSANRDANMFERPNDF- 358 Query: 416 PERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 + D + + FG G C+ + + +K + +L F Sbjct: 359 -------DLDRPNSARHLSFGQGVHACLAAQLISLQLKWFYVALLNRF 399 >5EX6-C nrPDB Length = 434 Score = 35.8 bits (81), Expect = 0.044, Method: Compositional matrix adjust. Identities = 64/340 (18%), Positives = 115/340 (33%), Gaps = 67/340 (19%) Query: 125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVI 184 E RLR LL+P FT K++ M P I Q ++ L G P L ++F + Sbjct: 131 EHTRLRRLLAPGFTHRKIRRMAPYIEQ---IVTERLDEMEREGSPADLIELFADEVPGPV 187 Query: 185 TSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPRE 244 GV P+D FL + L L Sbjct: 188 LCELLGV-------PRDDRA--------------MFLQL-CHRHLDASLSGRRRAAAGEA 225 Query: 245 VTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIF 304 + +L V R + K D L M+ +++ ++D EL + + Sbjct: 226 FSRYLVTMVARER--------KDPGDGLIGMVVAEHG------DTVTDEELRGVCVQMML 271 Query: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETL 364 AG + S ++ + L +P+ L+ ++ A + V+E + Sbjct: 272 AGDDNISGMIGLGVLALLRNPEQIAALRGDVPAA------------------ERAVDELI 313 Query: 365 RLFPIAMR-LERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKN 423 R + R +D + I G V+ +RDP + ++ R Sbjct: 314 RYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDADRLDVTR----- 368 Query: 424 KDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 + + FG G +C+G A + +++A + + F Sbjct: 369 ----EAVPHVAFGHGVHHCLGAALARLELRIAYTALWRRF 404 >6GII-A nrPDB Length = 479 Score = 35.8 bits (81), Expect = 0.050, Method: Compositional matrix adjust. Identities = 22/98 (22%), Positives = 40/98 (40%), Gaps = 8/98 (8%) Query: 359 VVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 418 E LR R ++VE+ G+ +P G +++ + + D ++ +PE F R Sbjct: 344 AAEECLRYNGPVAGWRRRTTREVEVEGVRLPVGANILMVVASANHDSAHFDDPEFFDIGR 403 Query: 419 FSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLAL 456 + N FG G C+G M M++ + Sbjct: 404 SNASEHLN--------FGYGAHQCLGRNLGRMEMQIMI 433 >1EHE-A nrPDB Length = 403 Score = 35.4 bits (80), Expect = 0.060, Method: Compositional matrix adjust. Identities = 71/350 (20%), Positives = 125/350 (35%), Gaps = 80/350 (22%) Query: 125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVI 184 E RS++ PTFT +K + P I + D L+ ++++ PV L F I Sbjct: 93 EHMHQRSMVEPTFTPEAVKNLQPYIQRTVDDLLEQMKQKGCANGPVDLVKEFALPVPSYI 152 Query: 185 TSTSFGVNIDSLN--NPQDPFVENTKKLLR------FDFLDPFFLSITVFPFLI-PILEV 235 T GV + L Q+ N R + LD +L+I V L+ P ++ Sbjct: 153 IYTLLGVPFNDLEYLTQQNAIRTNGSSTAREASAANQELLD--YLAILVEQRLVEPKDDI 210 Query: 236 LN-ICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLE 294 ++ +C +++K ++ + ++ FL L+ Sbjct: 211 ISKLCT-------------EQVKPGNIDKSDAVQIAFLLLV------------------- 238 Query: 295 LVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQME 354 AG T ++++ + LA HPD +L+ P+ AP Sbjct: 239 ----------AGNATMVNMIALGVATLAQHPDQLAQLKAN-----PSLAP---------- 273 Query: 355 YLDMVVNETLRLFPI-AMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEK 413 V E R A+ ++R K+DV I + ++ + + +RD + + P++ Sbjct: 274 ---QFVEELCRYHTASALAIKRTAKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDE 330 Query: 414 FLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 F R P FG G CI A + + Q F Sbjct: 331 FNMNR-------KWPPQDPLGFGFGDHRCIAEHLAKAELTTVFSTLYQKF 373 >6FSH-A nrPDB Length = 398 Score = 34.7 bits (78), Expect = 0.100, Method: Compositional matrix adjust. Identities = 67/353 (18%), Positives = 119/353 (33%), Gaps = 93/353 (26%) Query: 125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVI 184 E RLR LL+P FT +++ + P I + ++ L + G P L ++F + Sbjct: 95 EHTRLRHLLTPGFTQRRMRRLAPRIEE---IVTDRLDAMEQAGPPADLIELFADEVPGAV 151 Query: 185 TSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPRE 244 GV D +D F + +C Sbjct: 152 LCELIGVPRDD----RDMF--------------------------------MKLC----- 170 Query: 245 VTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQ---------NSKETESHKALSDLEL 295 L S+ + + + L D +L MI + S E ++D EL Sbjct: 171 -HGHLDASLSQKRRAALGDKFSR---YLLAMIARERKDPGDGFIGSIVAEHGDTITDEEL 226 Query: 296 VAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEY 355 + + AG + S ++ + L HP E+I A+ + + Sbjct: 227 RGVCVQLMLAGDDNVSGMIGLGVLALLRHP-------EQIAALRGDD-----------QS 268 Query: 356 LDMVVNETLRLFPIAMR-LERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKF 414 D V+E +R + R +DV + I +G V+ +RD Sbjct: 269 ADRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRD-------RAL 321 Query: 415 LPERFSKKNKDNID----PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 LP + D +D P + FG G +C+G + +++A + + F Sbjct: 322 LP------DADRLDVTRTPVPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRF 368 >4TX3-A nrPDB Length = 404 Score = 34.7 bits (78), Expect = 0.11, Method: Compositional matrix adjust. Identities = 66/346 (19%), Positives = 118/346 (34%), Gaps = 79/346 (22%) Query: 125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVI 184 E RLR LL+P FT +++ + P I + ++ L + G P L ++F + Sbjct: 101 EHTRLRHLLTPGFTQRRMRRLAPRIEE---IVTDRLDAMEQAGPPADLIELFADEVPGAV 157 Query: 185 TSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPRE 244 GV D Q F++ + L ++ R Sbjct: 158 LCELIGVPRDD----QAMFLQLCHRHLD-----------------------ASLSARKRA 190 Query: 245 VTN--FLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIF 302 F R V M R + F+ ++ E ++D EL + Sbjct: 191 AAGEAFARYLVAMMARERKDPGDG----FIGSIV-------AEHGDTITDEELRGVCVQL 239 Query: 303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 362 + AG + S ++ + L HP E+I A+ + + D V+E Sbjct: 240 MLAGDDNVSGMIGLGVLALLRHP-------EQIAALRGDD-----------QSADRAVDE 281 Query: 363 TLRLFPIAMR-LERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421 +R + R +DV + I +G V+ +RD LP Sbjct: 282 LIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRD-------RALLP----- 329 Query: 422 KNKDNID----PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 + D +D P + FG G +C+G + +++A + + F Sbjct: 330 -DADRLDVTRTPVPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRF 374 >5EX8-A nrPDB Length = 424 Score = 34.3 bits (77), Expect = 0.13, Method: Compositional matrix adjust. Identities = 38/180 (21%), Positives = 73/180 (40%), Gaps = 29/180 (16%) Query: 285 ESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAP 344 E+ A++D EL + + A + + +L+ + + P L+E+ P P Sbjct: 245 ENGDAITDAELTGVAAFVMGAAADQVARLLAAGAWLMVEQPAQFALLREK-----PETVP 299 Query: 345 PTYDTVLQMEYLDMVVNETLRLFPIAMRLE-RVCKKDVEINGMFIPKGVVVMIPSYALHR 403 E+LD ET+R + RV +DV I + G V A +R Sbjct: 300 ---------EWLD----ETMRYLTTDEKTHPRVATQDVRIGNQLVKAGDTVTCSLLAANR 346 Query: 404 DPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 P Y + ++F +++ +++ FG G +C+G A + K+++ + F Sbjct: 347 -PNYPSAEDEF---DITREKAEHL------AFGHGIHHCLGRAMAELMFKVSIPALAHRF 396 >3DBM-A nrPDB Length = 473 Score = 33.9 bits (76), Expect = 0.18, Method: Compositional matrix adjust. Identities = 34/153 (22%), Positives = 66/153 (43%), Gaps = 18/153 (11%) Query: 326 DVQQKLQEEIDAVLPNKAPP--TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383 ++ +L EEI + + T + + QM VV E+LR+ P K + I Sbjct: 298 NLHTQLAEEIRGAIKSYGDGNVTLEAIEQMPLTKSVVYESLRIEPPVPPQYGKAKSNFTI 357 Query: 384 ---NGMF-IPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGP 439 + F + KG ++ +DPK + PE+++P+RF + + Y + +GP Sbjct: 358 ESHDATFEVKKGEMLFGYQPFATKDPKVFDRPEEYVPDRFVGDGEALLK---YVWWSNGP 414 Query: 440 ---------RNCIGMRFALMNMKLALIRVLQNF 463 + C G F ++ +L +I + + + Sbjct: 415 ETESPTVENKQCAGKDFVVLITRLFVIELFRRY 447 >1DXF-A nrPDB Length = 256 Score = 32.7 bits (73), Expect = 0.35, Method: Compositional matrix adjust. Identities = 29/124 (23%), Positives = 54/124 (43%), Gaps = 19/124 (15%) Query: 220 FLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMID-- 277 L I + FLIP +E +E S + E + HR + + D Sbjct: 87 LLDIGFYNFLIPFVET-------KEEAELAVASTRYPPEGIRGVSVSHRANMFGTVADYF 139 Query: 278 SQNSK------ETESHKALSDLELVA--QSIIFIFAGYETTSSVLSFIMYELATHPDVQQ 329 +Q++K + ES + + +++ +A + + IF G ++ L + A+HPDVQ+ Sbjct: 140 AQSNKNITILVQIESQQGVDNVDAIAATEGVDGIFVGPSDLAAALGHLGN--ASHPDVQK 197 Query: 330 KLQE 333 +Q Sbjct: 198 AIQH 201 >2H57-A nrPDB Length = 190 Score = 31.6 bits (70), Expect = 0.86, Method: Compositional matrix adjust. Identities = 15/51 (29%), Positives = 23/51 (45%), Gaps = 2/51 (3%) Query: 57 FCMFDMECHKKYGKVWGFY--DGQQPVLAITDPDMIKTVLVKECYSVFTNR 105 F +FDM +Y +W Y +GQ + I D ++ V+ KE N Sbjct: 69 FTVFDMSGQGRYRNLWEHYYKEGQAIIFVIDSSDRLRMVVAKEELDTLLNH 119 >6ERI-Az nrPDB Length = 191 Score = 30.8 bits (68), Expect = 1.5, Method: Compositional matrix adjust. Identities = 14/33 (42%), Positives = 21/33 (63%), Gaps = 3/33 (9%) Query: 135 PTFTSGKLKEMVPII---AQYGDVLVRNLRREA 164 P TS + KE+ ++ A+ G V VRN+RR+A Sbjct: 111 PPLTSDRRKELAKVVSKLAEEGKVAVRNIRRDA 143 >1IS1-A nrPDB Length = 185 Score = 30.4 bits (67), Expect = 1.8, Method: Compositional matrix adjust. Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 3/43 (6%) Query: 135 PTFTSGKLKEMVPII---AQYGDVLVRNLRREAETGKPVTLKD 174 P T + K++V I+ A+ G V VRN+RR+A LKD Sbjct: 103 PPLTEERRKDLVKIVRGEAEGGRVAVRNIRRDANNDLKALLKD 145 >5MLC-9 nrPDB Length = 271 Score = 30.4 bits (67), Expect = 2.0, Method: Compositional matrix adjust. Identities = 14/33 (42%), Positives = 21/33 (63%), Gaps = 3/33 (9%) Query: 135 PTFTSGKLKEMVPII---AQYGDVLVRNLRREA 164 P TS + KE+ ++ A+ G V VRN+RR+A Sbjct: 189 PPLTSDRRKELAKVVSKLAEEGKVAVRNIRRDA 221 >6BLD-A nrPDB Length = 419 Score = 30.4 bits (67), Expect = 2.1, Method: Compositional matrix adjust. Identities = 26/125 (20%), Positives = 45/125 (36%), Gaps = 17/125 (13%) Query: 290 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 349 L+D ++ A ++ AG +TT +S + L P + L + D Sbjct: 245 LADADVAAFFVLLAVAGNDTTRQTISHGLKALTDFPSQKAWLLADFDT------------ 292 Query: 350 VLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWT 409 + V E +R M R D E+ G I G V++ + + D + Sbjct: 293 -----RIGTAVEELVRWATPVMTFRRTAAADFELGGQLIRAGEKVVMFYASGNWDEDAFC 347 Query: 410 EPEKF 414 PE+ Sbjct: 348 HPERL 352 >3J8B-C nrPDB Length = 547 Score = 30.0 bits (66), Expect = 2.8, Method: Compositional matrix adjust. Identities = 24/113 (21%), Positives = 50/113 (44%), Gaps = 7/113 (6%) Query: 80 PVLAITDPDMIKTVLVKECYSVFT--NRRPF-GPVGFMKSAISIAEDE----EWKRLRSL 132 P +A + D + ++ K+ + R+P GP M+ + A +WK S Sbjct: 371 PYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWKTCHSF 430 Query: 133 LSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVIT 185 + +GK+ ++ P + +LVR ++ E+ T V+ + SM+ ++ Sbjct: 431 IINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSVYDSISMETLS 483 >1EH1-A nrPDB Length = 185 Score = 29.6 bits (65), Expect = 3.5, Method: Compositional matrix adjust. Identities = 14/33 (42%), Positives = 20/33 (60%), Gaps = 3/33 (9%) Query: 135 PTFTSGKLKEMVPIIAQY---GDVLVRNLRREA 164 P T + K++V + QY G V +RN+RREA Sbjct: 104 PPLTEERRKDLVRAVRQYAEEGRVAIRNIRREA 136 >2YJN-B nrPDB Length = 381 Score = 29.3 bits (64), Expect = 3.8, Method: Compositional matrix adjust. Identities = 27/117 (23%), Positives = 53/117 (45%), Gaps = 20/117 (17%) Query: 299 SIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDM 358 ++ +FAG E T++ + + ++ P + +++ ++ A Sbjct: 216 ALRALFAGAEMTANTVVDAVLAVSAEPGLAERIADDPAAA------------------QR 257 Query: 359 VVNETLRLFPIAMRLER-VCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKF 414 V E LRL P A+ LER +V + I +G V++ A +RDP+ + EP++ Sbjct: 258 TVAEVLRLHP-ALHLERRTATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDRL 313 >5A5T-C nrPDB Length = 843 Score = 29.3 bits (64), Expect = 4.4, Method: Compositional matrix adjust. Identities = 24/113 (21%), Positives = 50/113 (44%), Gaps = 7/113 (6%) Query: 80 PVLAITDPDMIKTVLVKECYSVFT--NRRPF-GPVGFMKSAISIAEDE----EWKRLRSL 132 P +A + D + ++ K+ + R+P GP M+ + A +WK S Sbjct: 626 PYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWKTCHSF 685 Query: 133 LSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVIT 185 + +GK+ ++ P + +LVR ++ E+ T V+ + SM+ ++ Sbjct: 686 IINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSVYDSISMETLS 738 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6DA2-A nrPDB 618 e-177 5VEU-A nrPDB 561 e-160 2NNH-A nrPDB 384 e-107 5W0C-A nrPDB 377 e-105 4GQS-A nrPDB 376 e-105 1N6B-A nrPDB 367 e-102 4H1N-A nrPDB 362 e-100 6B82-A nrPDB 355 2e-98 3E6I-A nrPDB 355 3e-98 5E0E-A nrPDB 349 2e-96 5E58-A nrPDB 347 6e-96 2PG7-A nrPDB 345 3e-95 3IBD-A nrPDB 342 2e-94 6DWN-A nrPDB 326 1e-89 4R20-A nrPDB 323 9e-89 5UYS-A nrPDB 322 3e-88 3QZ1-A nrPDB 314 6e-86 2HI4-A nrPDB 314 6e-86 4R1Z-A nrPDB 313 1e-85 3DL9-A nrPDB 311 4e-85 5YLW-A nrPDB 311 5e-85 3JUS-A nrPDB 310 8e-85 5VBU-A nrPDB 307 7e-84 6AYB-A nrPDB 306 2e-83 4WMZ-A nrPDB 301 4e-82 5JLC-A nrPDB 299 2e-81 3MDV-A nrPDB 295 3e-80 6IQ5-A nrPDB 295 4e-80 6CR2-A nrPDB 291 5e-79 6C94-A nrPDB 288 3e-78 5FSA-A nrPDB 287 8e-78 3K9V-A nrPDB 277 7e-75 3TBG-A nrPDB 275 2e-74 2WX2-A nrPDB 275 4e-74 4KPA-A nrPDB 255 3e-68 2X2N-A nrPDB 252 3e-67 3L4D-A nrPDB 251 6e-67 3S79-A nrPDB 247 1e-65 2W0A-A nrPDB 243 9e-65 5VWS-A nrPDB 240 2e-63 2VE3-A nrPDB 238 3e-63 4RM4-A nrPDB 238 4e-63 5XNT-A nrPDB 235 3e-62 3EL3-A nrPDB 233 1e-61 4YT3-A nrPDB 232 3e-61 5L94-A nrPDB 231 4e-61 5OFQ-A nrPDB 230 1e-60 3EJB-B nrPDB 230 1e-60 2Y5N-A nrPDB 227 9e-60 4GGV-A nrPDB 224 6e-59 4Z5P-A nrPDB 223 1e-58 4JBT-A nrPDB 220 1e-57 4YZR-A nrPDB 219 2e-57 5CJE-A nrPDB 218 7e-57 4OQS-A nrPDB 217 9e-57 1GWI-A nrPDB 217 1e-56 1Z8P-A nrPDB 215 3e-56 2VZM-A nrPDB 215 3e-56 4OQR-A nrPDB 214 5e-56 5XW2-A nrPDB 213 2e-55 4UBS-A nrPDB 212 3e-55 6A7J-A nrPDB 210 1e-54 3N9Z-A nrPDB 208 5e-54 3MZS-A nrPDB 207 1e-53 5IT1-A nrPDB 207 1e-53 4XE3-A nrPDB 206 1e-53 6A7I-A nrPDB 205 3e-53 2WIO-A nrPDB 204 5e-53 3WVS-A nrPDB 204 1e-52 6GMF-A nrPDB 204 1e-52 5LIE-A nrPDB 203 1e-52 3R9C-A nrPDB 203 1e-52 3ABA-A nrPDB 201 8e-52 3A50-A nrPDB 199 2e-51 2WM5-A nrPDB 199 3e-51 6GK6-A nrPDB 198 4e-51 4WPZ-A nrPDB 198 4e-51 1UED-A nrPDB 198 5e-51 2Z36-A nrPDB 197 1e-50 4TRI-A nrPDB 196 1e-50 5DQN-A nrPDB 196 2e-50 1Q5D-A nrPDB 196 3e-50 5Y1I-A nrPDB 196 3e-50 5NWS-A nrPDB 195 3e-50 1ODO-A nrPDB 195 4e-50 5Z9I-A nrPDB 195 5e-50 3ABB-A nrPDB 194 8e-50 6CVC-A nrPDB 193 2e-49 1LG9-A nrPDB 193 2e-49 4Z5Q-A nrPDB 192 3e-49 4MM0-A nrPDB 192 3e-49 5YSW-A nrPDB 191 7e-49 3TYW-A nrPDB 191 7e-49 5XJN-A nrPDB 190 1e-48 5GWE-A nrPDB 190 1e-48 3NC3-A nrPDB 189 2e-48 3RWL-A nrPDB 189 3e-48 5FOI-A nrPDB 189 3e-48 1CPT-A nrPDB 188 4e-48 3A1L-A nrPDB 188 5e-48 6HQG-A nrPDB 187 8e-48 6HQW-A nrPDB 186 1e-47 6B11-A nrPDB 186 2e-47 1F4U-A nrPDB 186 2e-47 5FYF-A nrPDB 185 4e-47 3SN5-A nrPDB 183 1e-46 2ZBZ-A nrPDB 183 2e-46 2XKR-A nrPDB 183 2e-46 3P3Z-A nrPDB 180 2e-45 6M7L-A nrPDB 178 6e-45 5H1Z-A nrPDB 178 7e-45 6M7X-A nrPDB 177 1e-44 5DE9-A nrPDB 177 1e-44 3WEC-A nrPDB 176 1e-44 4ZGX-A nrPDB 176 1e-44 1UE8-A nrPDB 176 2e-44 5L1U-A nrPDB 175 4e-44 6F0B-A nrPDB 174 8e-44 2RFC-A nrPDB 173 1e-43 4PWV-A nrPDB 173 2e-43 3MGX-A nrPDB 172 4e-43 2FR7-A nrPDB 171 5e-43 6DCD-A nrPDB 167 9e-42 3TKT-A nrPDB 167 1e-41 6HQD-A nrPDB 166 2e-41 4DO1-A nrPDB 162 3e-40 5LIV-A nrPDB 162 3e-40 5HDI-A nrPDB 161 5e-40 6F88-A nrPDB 161 7e-40 2NZA-A nrPDB 156 3e-38 3BUJ-A nrPDB 153 1e-37 5KYO-A nrPDB 151 7e-37 3OFT-A nrPDB 148 4e-36 5HIW-A nrPDB 147 8e-36 3B98-A nrPDB 147 1e-35 1WIY-A nrPDB 146 3e-35 2WIY-A nrPDB 145 4e-35 6FYJ-A nrPDB 142 3e-34 5YHJ-A nrPDB 141 1e-33 3NV6-A nrPDB 134 1e-31 2ZQJ-A nrPDB 131 5e-31 6G71-A nrPDB 121 9e-28 3AWQ-A nrPDB 121 9e-28 5M0P-A nrPDB 119 3e-27 2RCM-A nrPDB 105 6e-23 Sequences not found previously or not previously below threshold: 5EX6-C nrPDB 196 1e-50 6FSH-A nrPDB 192 3e-49 1EHE-A nrPDB 191 6e-49 4TX3-A nrPDB 187 8e-48 3IVY-A nrPDB 180 2e-45 2UUQ-A nrPDB 163 2e-40 3OO3-A nrPDB 156 3e-38 6BLD-A nrPDB 156 3e-38 2X9P-A nrPDB 154 8e-38 5HH3-A nrPDB 153 2e-37 6GII-A nrPDB 153 2e-37 5EX8-A nrPDB 149 3e-36 6G5O-A nrPDB 136 3e-32 4FB2-A nrPDB 134 8e-32 5D3U-A nrPDB 131 9e-31 2IAG-A nrPDB 128 6e-30 2QBO-A nrPDB 127 1e-29 2IJ7-A nrPDB 122 4e-28 5OMS-A nrPDB 119 2e-27 4C9K-A nrPDB 119 4e-27 3DBM-A nrPDB 86 3e-17 2YJN-B nrPDB 67 2e-11 1NG6-A nrPDB 32 0.80 4YXC-B nrPDB 31 1.5 3BT7-A nrPDB 30 1.8 4M2J-A nrPDB 30 1.9 4YXB-D nrPDB 30 3.2 4DJD-D nrPDB 30 3.2 3I7T-A nrPDB 30 3.2 3RFT-A nrPDB 29 5.0 2XSA-A nrPDB 29 7.5 3RP9-A nrPDB 29 7.6 5EUV-A nrPDB 28 9.0 4M60-A nrPDB 28 9.3 6FRK-r nrPDB 28 9.7 5M73-D nrPDB 28 9.7 >6DA2-A nrPDB Length = 487 Score = 618 bits (1593), Expect = e-177, Method: Composition-based stats. Identities = 481/483 (99%), Positives = 482/483 (99%) Query: 21 LLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQP 80 + YLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQP Sbjct: 1 MAYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQP 60 Query: 81 VLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG 140 VLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG Sbjct: 61 VLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSG 120 Query: 141 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ 200 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ Sbjct: 121 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ 180 Query: 201 DPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESR 260 DPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESR Sbjct: 181 DPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESR 240 Query: 261 LEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYE 320 LEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYE Sbjct: 241 LEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYE 300 Query: 321 LATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKD 380 LATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKD Sbjct: 301 LATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKD 360 Query: 381 VEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPR 440 VEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPR Sbjct: 361 VEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPR 420 Query: 441 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTV 500 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTV Sbjct: 421 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTV 480 Query: 501 SGA 503 SGA Sbjct: 481 SGA 483 >5VEU-A nrPDB Length = 480 Score = 561 bits (1445), Expect = e-160, Method: Composition-based stats. Identities = 400/477 (83%), Positives = 437/477 (91%), Gaps = 1/477 (0%) Query: 22 LYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPV 81 + LYGT +HGLFK+LGIPGPTPLP LGN+LSY +G FD EC+KKYGK+WG Y+GQ PV Sbjct: 1 MALYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPV 60 Query: 82 LAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGK 141 LAITDPD+I+TVLVKECYSVFTNRR GPVGFMKSAIS+AEDEEWKR+RSLLSPTFTSGK Sbjct: 61 LAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGK 120 Query: 142 LKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQD 201 LKEM PIIAQYGDVLVRNLRREAE GKPVTLKD+FGAYSMDVIT TSFGVNIDSLNNPQD Sbjct: 121 LKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQD 180 Query: 202 PFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRL 261 PFVE+TKK L+F FLDP FLSI +FPFL P+ E LN+ +FP++ NFL KSV RMK+SRL Sbjct: 181 PFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRL 240 Query: 262 EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYEL 321 D QKHR+DFLQLMIDSQNSKETESHKALSDLEL AQSIIFIFAGYETTSSVLSF +YEL Sbjct: 241 NDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYEL 300 Query: 322 ATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDV 381 ATHPDVQQKLQ+EIDAVLPNKAPPTYD V+QMEYLDMVVNETLRLFP+A+RLER CKKDV Sbjct: 301 ATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDV 360 Query: 382 EINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441 EING+FIPKG +V+IP+YALH DPKYWTEPE+F PERFSKK KD+IDPYIYTPFG+GPRN Sbjct: 361 EINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKK-KDSIDPYIYTPFGTGPRN 419 Query: 442 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDG 498 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL GLLQPEKP+VLKV+SRDG Sbjct: 420 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDG 476 >2NNH-A nrPDB Length = 476 Score = 384 bits (985), Expect = e-107, Method: Composition-based stats. Identities = 112/441 (25%), Positives = 173/441 (39%), Gaps = 17/441 (3%) Query: 39 PGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 97 PGPTPLP +GN+L K C K YG V+ Y G P++ + +K L+ Sbjct: 13 PGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDN 72 Query: 98 CYSVFTNRR--PFGPVGFMKSAISIAEDEEWKRLRSLLSPT---FTSGKLKEMVPIIAQY 152 F+ R P I + + WK +R T F GK + + + + Sbjct: 73 G-EEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGK-RSIEDRVQEE 130 Query: 153 GDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR 212 LV LR+ + P + G +VI S F D + ++ + R Sbjct: 131 AHCLVEELRKTKAS--PCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFR 188 Query: 213 FDFLDPFFLSITVFPFLIPILEVLNICVFPR--EVTNFLRKSVKRMKESRLEDTQKHRVD 270 P+ FP LI + V +++R+ VK + S + + +D Sbjct: 189 I-LNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFID 247 Query: 271 FLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQK 330 + ++ + + + LV AG ETTS+ L + + L HP+V K Sbjct: 248 CFLIKMEQEKDNQK---SEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAK 304 Query: 331 LQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP-IAMRLERVCKKDVEINGMFIP 389 +QEEID V+ P M Y D VV+E R + + D + IP Sbjct: 305 VQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIP 364 Query: 390 KGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449 KG +M ++ D K + P F P F KN + + PF +G R C G A Sbjct: 365 KGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLAR 424 Query: 450 MNMKLALIRVLQNFSFKPCKE 470 M + L L +LQNF+ K + Sbjct: 425 MELFLFLTTILQNFNLKSVDD 445 >5W0C-A nrPDB Length = 477 Score = 377 bits (967), Expect = e-105, Method: Composition-based stats. Identities = 106/442 (23%), Positives = 180/442 (40%), Gaps = 17/442 (3%) Query: 39 PGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 97 PGPTPLP +GNIL K K YG V+ Y G +P++ + + +K L+ + Sbjct: 14 PGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALI-D 72 Query: 98 CYSVFTNRR--PFGPVGFMKSAISIAEDEEWKRLRSLLS---PTFTSGKLKEMVPIIAQY 152 F+ R P I + ++WK +R F GK + + + + Sbjct: 73 LGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGK-RSIEDRVQEE 131 Query: 153 GDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR 212 LV LR+ + P + G +VI S F D + +E + ++ Sbjct: 132 ARCLVEELRKTKAS--PCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIK 189 Query: 213 FDFLDPFFLSITVFPFLIPILEVLNICVFPRE--VTNFLRKSVKRMKESRLEDTQKHRVD 270 P+ F +I + + + +++ + VK +ES + + +D Sbjct: 190 I-LSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFID 248 Query: 271 FLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQK 330 + ++ + + + L ++ AG ETTS+ L + + L HP+V K Sbjct: 249 CFLMKMEKEKHNQP---SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAK 305 Query: 331 LQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAM-RLERVCKKDVEINGMFIP 389 +QEEI+ V+ P M Y D VV+E R + L D++ IP Sbjct: 306 VQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIP 365 Query: 390 KGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449 KG ++I ++ D K + PE F P F + + + PF +G R C+G A Sbjct: 366 KGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAG 425 Query: 450 MNMKLALIRVLQNFSFKPCKET 471 M + L L +LQNF+ K + Sbjct: 426 MELFLFLTSILQNFNLKSLVDP 447 >4GQS-A nrPDB Length = 477 Score = 376 bits (966), Expect = e-105, Method: Composition-based stats. Identities = 109/442 (24%), Positives = 177/442 (40%), Gaps = 17/442 (3%) Query: 39 PGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 97 PGPTPLP +GNIL K K YG V+ Y G + ++ + +++K L+ + Sbjct: 14 PGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALI-D 72 Query: 98 CYSVFTNRR--PFGPVGFMKSAISIAEDEEWKRLRSLLS---PTFTSGKLKEMVPIIAQY 152 F+ R P I + + WK +R F GK + + + + Sbjct: 73 LGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGK-RSIEDRVQEE 131 Query: 153 GDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR 212 LV LR+ + P + G +VI S F D + +E + +R Sbjct: 132 ARCLVEELRKTKAS--PCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIR 189 Query: 213 FDFLDPFFLSITVFPFLIPILEVLNICVFPRE--VTNFLRKSVKRMKESRLEDTQKHRVD 270 P+ FP +I + + + + + + VK +ES + + +D Sbjct: 190 I-VSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFID 248 Query: 271 FLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQK 330 + ++ + LV + + AG ETTS+ L + + L HP+V K Sbjct: 249 CF---LIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAK 305 Query: 331 LQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP-IAMRLERVCKKDVEINGMFIP 389 +QEEI+ V+ P M Y D VV+E R I L DV+ IP Sbjct: 306 VQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIP 365 Query: 390 KGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449 KG ++ ++ D K + PE F P F + + + PF +G R C+G A Sbjct: 366 KGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLAR 425 Query: 450 MNMKLALIRVLQNFSFKPCKET 471 M + L L +LQNF+ K + Sbjct: 426 MELFLFLTFILQNFNLKSLIDP 447 >1N6B-A nrPDB Length = 473 Score = 367 bits (941), Expect = e-102, Method: Composition-based stats. Identities = 107/442 (24%), Positives = 180/442 (40%), Gaps = 20/442 (4%) Query: 39 PGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 97 PGPTP P +GNIL K + + YG V+ Y G +P + + + +K LV + Sbjct: 13 PGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLHGYEAVKEALV-D 71 Query: 98 CYSVFTNRRPFGPVGFMKSA--ISIAEDEEWKRLRSLLS---PTFTSGKLKEMVPIIAQY 152 F R + + I+ + + WK +R F GK + + I + Sbjct: 72 LGEEFAGRGSVPILEKVSKGLGIAFSNAKTWKEMRRFSLMTLRNFGMGK-RSIEDRIQEE 130 Query: 153 GDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR 212 LV LR+ P + G +VI S F D + +E+ + + Sbjct: 131 ARCLVEELRKT--NASPCDPTFILGCAPCNVICSVIFHNRFDYKDEEFLKLMESLHENVE 188 Query: 213 FDFLDPFFLSITVFPFLIPILEVLNICVFP--REVTNFLRKSVKRMKESRLEDTQKHRVD 270 P+ FP L+ ++ + + NF+ + VK ++ + + +D Sbjct: 189 L-LGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQKLLDVNNPRDFID 247 Query: 271 FLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQK 330 + + E E++ + LV AG ETTS+ L + + L HP+V + Sbjct: 248 CFLIKM------EQENNLEFTLESLVIAVSDLFGAGTETTSTTLRYSLLLLLKHPEVAAR 301 Query: 331 LQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMR-LERVCKKDVEINGMFIP 389 +QEEI+ V+ P +M Y D V++E R + L +DV FIP Sbjct: 302 VQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTRDVRFRNYFIP 361 Query: 390 KGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449 KG ++ ++ D K + P+ F P F ++ + + PF +G R C+G A Sbjct: 362 KGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGKRMCVGEGLAR 421 Query: 450 MNMKLALIRVLQNFSFKPCKET 471 M + L L +LQNF + E Sbjct: 422 MELFLFLTSILQNFKLQSLVEP 443 >4H1N-A nrPDB Length = 479 Score = 362 bits (929), Expect = e-100, Method: Composition-based stats. Identities = 113/454 (24%), Positives = 185/454 (40%), Gaps = 18/454 (3%) Query: 39 PGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 97 PGP+PLP LGN+L KG + +KYG V+ Y G +PV+ + D I+ LV + Sbjct: 13 PGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLCGTDAIREALVDQ 72 Query: 98 CYSVFTNRRPFGPVG--FMKSAISIAEDEEWKRLRSLLSPT---FTSGKLKEMVPIIAQY 152 F+ R V F + A E W+ LR T F GK + + I + Sbjct: 73 A-EAFSGRGKIAVVDPIFQGYGVIFANGERWRALRRFSLATMRDFGMGK-RSVEERIQEE 130 Query: 153 GDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR 212 LV LR+ G + +F + + ++I S FG D + + + Sbjct: 131 ARCLVEELRKSK--GALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRLL-DLFFQSF 187 Query: 213 FDFLDPFFLSITVFPFLIPILEVLNICVF--PREVTNFLRKSVKRMKESRLEDTQKHRVD 270 +F + + ++ +E+ F+ +SV++ + + + D Sbjct: 188 SLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRATLDPSNPR---D 244 Query: 271 FLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQK 330 F+ + + +++ L+ + AG ETTS+ L + + +P V ++ Sbjct: 245 FIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLMLKYPHVTER 304 Query: 331 LQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP-IAMRLERVCKKDVEINGMFIP 389 +Q+EI+ V+ + PP D +M Y D V++E RL I + KD + G IP Sbjct: 305 VQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRGYVIP 364 Query: 390 KGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449 K V + DP+Y+ P F P F N + PF G R C+G A Sbjct: 365 KNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRICLGEGIAR 424 Query: 450 MNMKLALIRVLQNFSF-KPCKETQIPLKLSLGGL 482 + L +LQNFS P I L G+ Sbjct: 425 TELFLFFTTILQNFSIASPVPPEDIDLTPRESGV 458 >6B82-A nrPDB Length = 509 Score = 355 bits (911), Expect = 2e-98, Method: Composition-based stats. Identities = 113/478 (23%), Positives = 205/478 (42%), Gaps = 30/478 (6%) Query: 39 PGPTPLPFLGNILSYHKG--FCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVK 96 P LP +G+++S +F + KKYG ++ G +L + + K +L+K Sbjct: 26 PSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNNHHHAKEILIK 85 Query: 97 ECYSVFTNRRPFGPVGFMKSAISIA---EDEEWKRLRSLLSPT---FTSGKLKEMVPIIA 150 + R + IA WK R ++ F G + + II Sbjct: 86 KGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKMVHGALCMFGEGSV-SIEKIIC 144 Query: 151 QYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKL 210 + + L + V L +V+ + F + + + ++ ++ + Sbjct: 145 REASSMCEVLTESQNSA--VDLGPELTRAVTNVVCALCFNSSYKRGDAEFESMLQYSQGI 202 Query: 211 LR---FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKH 267 + D L F + +FP L +L C+ R+ L+K + K + ++ Q+ Sbjct: 203 VDTVAKDSLVDIFPWLQIFPNKD--LRILRQCISIRD--KLLQKKYEEHKVTYSDNVQR- 257 Query: 268 RVDFLQLMIDSQNSKETESHKA----LSDLELVAQSIIFIFAGYETTSSVLSFIMYELAT 323 D L ++ ++ S E + L++ ++ AG ETT++ L + + L Sbjct: 258 --DLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGEIFGAGVETTTTTLKWSIAYLVH 315 Query: 324 HPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPI-AMRLERVCKKDVE 382 +P VQ+K+QEE+D+ + + P + YL+ + E +R+ P+ + + V +D Sbjct: 316 NPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATICEVMRIRPVSPLLIPHVALQDSS 375 Query: 383 INGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNI--DPYIYTPFGSGPR 440 + + KG V+I ++LH D K W PE F P RF + D + Y PFG+G R Sbjct: 376 VGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGVR 435 Query: 441 NCIGMRFALMNMKLALIRVLQNFSFK-PCKETQIPLKLSLGGLLQPEK-PVVLKVESR 496 C+G A M + L L +LQ F+ + P + L+ G +LQP+K VV KV + Sbjct: 436 VCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPKKFKVVAKVRAD 493 >3E6I-A nrPDB Length = 476 Score = 355 bits (910), Expect = 3e-98, Method: Composition-based stats. Identities = 108/441 (24%), Positives = 180/441 (40%), Gaps = 16/441 (3%) Query: 39 PGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 97 PGP PLP +GN+ K +++G V+ Y G Q ++ + +K L+ + Sbjct: 13 PGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALL-D 71 Query: 98 CYSVFTNRRPFGPVGFMKS-AISIAEDEEWKRLRSLLSPTFTSGKLKEM--VPIIAQYGD 154 F+ R + I WK +R T + + + I + Sbjct: 72 YKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAH 131 Query: 155 VLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFD 214 L+ LR+ G+P + G +VI F + D + + + Sbjct: 132 FLLEALRKTQ--GQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHL- 188 Query: 215 FLDPFFLSITVFPFLIPILEVLNICVFPR--EVTNFLRKSVKRMKESRLEDTQKHRVDFL 272 P+ FP + L + V EV ++ + VK +S + + D L Sbjct: 189 LSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCL 248 Query: 273 QLMIDSQNSKETESHKALSDLE-LVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKL 331 + ++ KE S + L ++ + FAG ETTS+ L + + L +P++++KL Sbjct: 249 LVEME----KEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKL 304 Query: 332 QEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMR-LERVCKKDVEINGMFIPK 390 EEID V+ P +M Y+D VV+E R + L +D G IPK Sbjct: 305 HEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPK 364 Query: 391 GVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALM 450 G VV+ ++ D + + +PEKF PE F +N + PF +G R C G A M Sbjct: 365 GTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARM 424 Query: 451 NMKLALIRVLQNFSFKPCKET 471 + L L +LQ+F+ KP + Sbjct: 425 ELFLLLCAILQHFNLKPLVDP 445 >5E0E-A nrPDB Length = 463 Score = 349 bits (895), Expect = 2e-96, Method: Composition-based stats. Identities = 110/458 (24%), Positives = 184/458 (40%), Gaps = 18/458 (3%) Query: 49 NILSYHKG-FCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRP 107 N+L +G F +KYG V+ + G +PV+ + + I+ LV + F+ R Sbjct: 14 NLLQMDRGGFLNSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQA-EAFSGRGT 72 Query: 108 FGPVG--FMKSAISIAEDEEWKRLRSLLSPT---FTSGKLKEMVPIIAQYGDVLVRNLRR 162 V F + A E WK LR T F GK + + I + LV R+ Sbjct: 73 IAVVEPIFRGYGVVFANGERWKALRRFSLVTMRDFGMGK-RSVEERIQEEARCLVEEFRK 131 Query: 163 EAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDP--FVENTKKLLRFDFLDPFF 220 G P+ +F + ++I S FG D ++ ++ L F F Sbjct: 132 SQ--GAPLDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVF 189 Query: 221 LSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQN 280 + F P I +E+ +++ +SV++ + + H DF+ + Sbjct: 190 ELFSGFLKYFPGTH-RQISRNLQEILDYIGQSVEKHRATLD---PSHPRDFIDTYLLRME 245 Query: 281 SKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLP 340 +++ H LV + FAG ET+S+ L + + +P V +K+Q+EID V+ Sbjct: 246 KEKSNQHTEFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIG 305 Query: 341 NKAPPTYDTVLQMEYLDMVVNETLRLFP-IAMRLERVCKKDVEINGMFIPKGVVVMIPSY 399 + PT + +M Y + V+ E R I + + KD G +PK V Sbjct: 306 SHRLPTLEDRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILS 365 Query: 400 ALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRV 459 + DP+Y+ +P+ F P+ F N + PF G R C+G A + L + Sbjct: 366 SALHDPQYFEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTI 425 Query: 460 LQNFSF-KPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496 LQNFS P I L G + + + +R Sbjct: 426 LQNFSLSSPVAPKDIDLSPKESGFGKVPQTYQICFLAR 463 >5E58-A nrPDB Length = 493 Score = 347 bits (890), Expect = 6e-96, Method: Composition-based stats. Identities = 106/444 (23%), Positives = 179/444 (40%), Gaps = 18/444 (4%) Query: 49 NILSYHKG-FCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRP 107 N+L +G F M +KYG V+ + G +PV+ + + I+ LV + F+ R Sbjct: 42 NLLQMDRGGFLNSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQA-EAFSGRGT 100 Query: 108 FGPVG--FMKSAISIAEDEEWKRLRSLLSPT---FTSGKLKEMVPIIAQYGDVLVRNLRR 162 + + + E WK LR T F GK + + I + LV L++ Sbjct: 101 IAVIKPVIGDYGMIFSNGERWKVLRRFSLATMRDFGMGK-RSVEDRIQEEAQCLVEELQK 159 Query: 163 EAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKL--LRFDFLDPFF 220 G P+ +F + ++I S FG D + ++ + L F F Sbjct: 160 SQ--GAPLDPTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQVF 217 Query: 221 LSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQN 280 + F P I +E+ +++ +SV++ + + + DF+ + Sbjct: 218 ELFSGFMKYFPG-AHRQITRNLQEILDYVGQSVEKHRATLDPSNPR---DFIDTYLLRME 273 Query: 281 SKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLP 340 +++ H L+ + FAG ETTS+ L + + +P V +K+Q+EID V+ Sbjct: 274 KEKSNQHTEFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIG 333 Query: 341 NKAPPTYDTVLQMEYLDMVVNETLRLFPIAM-RLERVCKKDVEINGMFIPKGVVVMIPSY 399 + PT + +M Y D V++E R +A KD G +PK V Sbjct: 334 SHRLPTLEDRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILS 393 Query: 400 ALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRV 459 + DP+Y+ +P F P+ F N + PF G R C+G A + L + Sbjct: 394 SALHDPQYFEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTI 453 Query: 460 LQNFSFKPC-KETQIPLKLSLGGL 482 LQNFS I L G+ Sbjct: 454 LQNFSVSSSVAPKDIDLSPKESGI 477 >2PG7-A nrPDB Length = 476 Score = 345 bits (885), Expect = 3e-95, Method: Composition-based stats. Identities = 108/442 (24%), Positives = 184/442 (41%), Gaps = 17/442 (3%) Query: 39 PGPTPLPFLGNILSYH-KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKE 97 PGPTPLPF+GN L + + M+ ++YG V+ + G + V+ + D ++ LV + Sbjct: 13 PGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQ 72 Query: 98 CYSVFTNRRPFGPVG--FMKSAISIAEDEEWKRLRSLLSPT---FTSGKLKEMVPIIAQY 152 F+ R F + + E K+LR T F GK + + I + Sbjct: 73 A-EEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGK-RGIEERIQEE 130 Query: 153 GDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR 212 L+ LR G + +VI+S FG D + + + + Sbjct: 131 AGFLIDALR--GTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQ 188 Query: 213 FDFLDPFFLSITVFPFLIPILEVLNICVFP--REVTNFLRKSVKRMKESRLEDTQKHRVD 270 F +F ++ L F + + +F+ K V+ + + ++ + D Sbjct: 189 FTSTSTG-QLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPR---D 244 Query: 271 FLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQK 330 F+ + +E + LV ++ G ET S+ L + L HP+V+ K Sbjct: 245 FIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFLLLMKHPEVEAK 304 Query: 331 LQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPI-AMRLERVCKKDVEINGMFIP 389 + EEID V+ P ++ +M Y++ V++E R + M L R KKD + F+P Sbjct: 305 VHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLP 364 Query: 390 KGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449 KG V ++ RDP +++ P+ F P+ F + + PF G RNC G A Sbjct: 365 KGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLAR 424 Query: 450 MNMKLALIRVLQNFSFKPCKET 471 M + L V+QNF K + Sbjct: 425 MELFLFFTTVMQNFRLKSSQSP 446 >3IBD-A nrPDB Length = 476 Score = 342 bits (878), Expect = 2e-94, Method: Composition-based stats. Identities = 99/458 (21%), Positives = 177/458 (38%), Gaps = 18/458 (3%) Query: 49 NILSYHK-GFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRP 107 N+L + G + +KYG V+ + G +PV+ + + I+ LV + F+ R Sbjct: 23 NLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKA-EAFSGRGK 81 Query: 108 FGPVG--FMKSAISIAEDEEWKRLRSLLSPT---FTSGKLKEMVPIIAQYGDVLVRNLRR 162 V F + A WK LR T F GK + + I + L+ LR+ Sbjct: 82 IAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGK-RSVEERIQEEAQCLIEELRK 140 Query: 163 EAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLS 222 G + +F + + ++I S FG + + + F Sbjct: 141 SK--GALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSL-ISSVFGQL 197 Query: 223 ITVFPFLIPILEVLNICVFP--REVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQN 280 +F + + V+ +E+ ++ SV++ +E+ + D + + Sbjct: 198 FELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPR---DLIDTYLLHME 254 Query: 281 SKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLP 340 +++ +H S L ++ FAG ETTS+ L + + +P V +++ EI+ V+ Sbjct: 255 KEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIG 314 Query: 341 NKAPPTYDTVLQMEYLDMVVNETLRLFPI-AMRLERVCKKDVEINGMFIPKGVVVMIPSY 399 PP +M Y + V+ E R + M + + + G IPK V + Sbjct: 315 PHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILS 374 Query: 400 ALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRV 459 DP Y+ +P+ F P+ F N + PF G R C+G A + L + Sbjct: 375 TALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTI 434 Query: 460 LQNFSF-KPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496 LQNFS P I L G+ + ++ R Sbjct: 435 LQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR 472 >6DWN-A nrPDB Length = 491 Score = 326 bits (835), Expect = 1e-89, Method: Composition-based stats. Identities = 101/467 (21%), Positives = 188/467 (40%), Gaps = 29/467 (6%) Query: 39 PGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKEC 98 PGP P +G++L+ K + ++YG V G PV+ ++ D I+ LV++ Sbjct: 14 PGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQG 73 Query: 99 YSVFTNRRPFGPVGFMKSAISIAEDEE----WKRLRSLLSPTFTSGKLKE---------M 145 F R + + S++ + W R L S + + Sbjct: 74 -DDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYL 132 Query: 146 VPIIAQYGDVLVRNLRR-EAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFV 204 +++ +VL+ L+ A G + V + + +VI + FG D + + Sbjct: 133 EEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVT-NVICAICFGRRYD---HNHQELL 188 Query: 205 ENTKKLLRFDFLDPFFLSITVFPFL--IPILEVLNICVFPREVTNFLRKSVKRMKESRLE 262 F + P L +P + + +F++K VK ++ Sbjct: 189 SLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTF-- 246 Query: 263 DTQKHRVDFLQLMIDSQNSKETESHK--ALSDLELVAQSIIFIFAGYETTSSVLSFIMYE 320 + H D +I+ K+ + + LSD +++ + AG++T ++ +S+ + Sbjct: 247 -EKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMY 305 Query: 321 LATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP-IAMRLERVCKK 379 L +P VQ+K+QEE+D V+ P + Y++ + ET R + + + Sbjct: 306 LVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTR 365 Query: 380 DVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK--DNIDPYIYTPFGS 437 D + G +IPKG V + + ++ D K W P +FLPERF + D + FG Sbjct: 366 DTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGM 425 Query: 438 GPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQ 484 G R CIG A + L L +LQ F ++ + G ++ Sbjct: 426 GKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMK 472 >4R20-A nrPDB Length = 486 Score = 323 bits (828), Expect = 9e-89, Method: Composition-based stats. Identities = 112/445 (25%), Positives = 196/445 (44%), Gaps = 22/445 (4%) Query: 57 FCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGF--- 113 + + +YG ++G Y G L +++ +++ VL++ F R Sbjct: 41 PHLLFTQLSSQYGPLFGLYAGPHLTLVVSEIGLVREVLLQRGRE-FAGRPKMVTTDLLTQ 99 Query: 114 MKSAISIAE-DEEWKRLRSLLSPTFTSGKLKE--MVPIIAQYGDVLVRNLRREAETGKPV 170 I+ A+ WK R L+ +FT + I+ + D L L+ A G+ Sbjct: 100 GGKDIAFADYSPLWKNHRRLVHSSFTLFGEGSNKLQTIVQEAADSLCEELQ--ACRGQSS 157 Query: 171 TLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRF---DFLDPFFLSITVFP 227 L V +VI F + + ++ +++ L F + +FP Sbjct: 158 DLSVVLMRAVTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQTIARGGLVDIFPWLRIFP 217 Query: 228 FLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESH 287 L+ L CV R+ L K + K+S + D L ++ Q + Sbjct: 218 NKD--LKRLKECVSIRD--QLLYKKLLEHKKSLTPGEPR---DLLDALLIGQQRG-SGGA 269 Query: 288 KALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTY 347 +++ ++ + AG ETTS+ L + + L HP +Q+++Q E+D + PP Sbjct: 270 DDITEDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCL 329 Query: 348 DTVLQMEYLDMVVNETLRLFPIAM-RLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPK 406 + LD V+ E +R+ P++ + V +D + G +PKG V++ +A+H DPK Sbjct: 330 SDRPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPK 389 Query: 407 YWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 466 +W +PE+F PERF + + + PFG+GPR C+G A + + L + R LQ FSF Sbjct: 390 HWDQPEQFNPERFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFS 449 Query: 467 PCKETQIP-LKLSLGGLLQPEKPVV 490 E +P L+ G +LQPE+ V Sbjct: 450 CPSEASLPDLQGRFGVVLQPERYTV 474 >5UYS-A nrPDB Length = 494 Score = 322 bits (824), Expect = 3e-88, Method: Composition-based stats. Identities = 120/478 (25%), Positives = 201/478 (42%), Gaps = 26/478 (5%) Query: 36 LGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLV 95 L +P LPFL H + KKYG ++ G + + + + K VL+ Sbjct: 14 LSLPLVGSLPFLPRHGHMHNN----FFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLI 69 Query: 96 KECYSVFTNRRPFGPVGFM---KSAISIAE-DEEWKRLRSLLSPTFTSGKL--KEMVPII 149 K+ F+ R + + I+ A+ W+ R L TF K +++ II Sbjct: 70 KKGKD-FSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKII 128 Query: 150 AQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLN---NPQDPFVEN 206 Q L L G+ + + +VI+ F + + + N + E Sbjct: 129 CQEISTLCDML--ATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEG 186 Query: 207 TKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQK 266 L D L + +FP LE L V R + L K ++ KE D+ Sbjct: 187 IIDNLSKDSLVDLVPWLKIFPNKT--LEKLKSHVKIR--NDLLNKILENYKEKFRSDSIT 242 Query: 267 HRVDFL---QLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELAT 323 + +D L ++ D+ N+ + + LSD ++ AG ETT+SV+ + + L Sbjct: 243 NMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLH 302 Query: 324 HPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMR-LERVCKKDVE 382 +P V++KL EEID + PT ++ L+ + E LRL P+A + D Sbjct: 303 NPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSS 362 Query: 383 INGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNI--DPYIYTPFGSGPR 440 I + KG V+I +ALH + K W +P++F+PERF + Y PFG+GPR Sbjct: 363 IGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPR 422 Query: 441 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDG 498 +CIG A + L + +LQ F + + Q+P + ++ +K++ R Sbjct: 423 SCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQA 480 >3QZ1-A nrPDB Length = 496 Score = 314 bits (804), Expect = 6e-86, Method: Composition-based stats. Identities = 112/483 (23%), Positives = 197/483 (40%), Gaps = 24/483 (4%) Query: 31 GLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMI 90 G +K + P +P ++L + + +K G V+ G Q V+ + I Sbjct: 21 GRWKLRNLHLPPLVPGFLHLLQ--PNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTI 78 Query: 91 KTVLVKECYSVFTNRRPFGPVGFMKS---AISIAEDEE-WKRLRSLLSPTFTSGKLKEMV 146 + ++++ F R + IS+ + WK + L G M Sbjct: 79 EEAMIRKWVD-FAGRPQIPSYKLVSQRCQDISLGDYSLLWKAHKKLTRSALLLGTRSSME 137 Query: 147 PIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVEN 206 P + Q +R +A G PVT++ F + +I +FG D+L + V++ Sbjct: 138 PWVDQLTQEFCERMRVQA--GAPVTIQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQD 195 Query: 207 TKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQK 266 K +D L + F P + + + + K ++R KES + + Sbjct: 196 LMKT--WDHWSIQILDMVPFLRFFPNPGLWRLKQAIENRDHMVEKQLRRHKESMVAGQWR 253 Query: 267 HRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPD 326 D++ + Q +E L + + + G ETT+S LS+ + L HP+ Sbjct: 254 DMTDYMLQGVGRQRVEE--GPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPE 311 Query: 327 VQQKLQEEIDAVLPNKA---PPTYDTVLQMEYLDMVVNETLRLFPIAM-RLERVCKKDVE 382 +Q++LQEE+D L A TY ++ L+ + E LRL P+ L + Sbjct: 312 IQRRLQEELDRELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSS 371 Query: 383 INGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNC 442 I G IP+G+VV+ H D W +P +F P+RF + + FG G R C Sbjct: 372 IFGYDIPEGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGANP----SALAFGCGARVC 427 Query: 443 IGMRFALMNMKLALIRVLQNFSFKPCKETQIP--LKLSLGGLLQPEKPVVLKVESRDGTV 500 +G A + + + L R+LQ F+ P +P G+ +P ++++ R G Sbjct: 428 LGESLARLELFVVLARLLQAFTLLPPPVGALPSLQPDPYCGVNLKVQPFQVRLQPR-GVE 486 Query: 501 SGA 503 +GA Sbjct: 487 AGA 489 >2HI4-A nrPDB Length = 495 Score = 314 bits (804), Expect = 6e-86, Method: Composition-based stats. Identities = 97/465 (20%), Positives = 179/465 (38%), Gaps = 26/465 (5%) Query: 39 PGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKEC 98 P P P LG++L+ K + ++YG V G PVL ++ D I+ LV++ Sbjct: 19 PEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQG 78 Query: 99 YSVFTNRRPFGPVGFMKSA----ISIAEDEEWKRLRSLLSPTFTSGKLKE---------M 145 F R + S W R L + + + Sbjct: 79 -DDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYL 137 Query: 146 VPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVE 205 +++ L+ L+ + +VI + FG + ++ V+ Sbjct: 138 EEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVK 197 Query: 206 NTKKLLRFDFLDPFFLSITVFPFL--IPILEVLNICVFPREVTNFLRKSVKRMKESRLED 263 NT + + + FP L +P + F + FL+K+V+ + ++ Sbjct: 198 NTHEFVETASSGN---PLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKN 254 Query: 264 TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELAT 323 + + D + S + ++V AG++T ++ +S+ + L T Sbjct: 255 SVR---DITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVT 311 Query: 324 HPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAM-RLERVCKKDVE 382 P++Q+K+Q+E+D V+ + P Q+ YL+ + ET R + +D Sbjct: 312 KPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTT 371 Query: 383 INGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP---YIYTPFGSGP 439 +NG +IPK V + + ++ DP+ W +P +F PERF + I+ FG G Sbjct: 372 LNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGK 431 Query: 440 RNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQ 484 R CIG A + L L +LQ F ++ L G ++ Sbjct: 432 RRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMK 476 >4R1Z-A nrPDB Length = 439 Score = 313 bits (802), Expect = 1e-85, Method: Composition-based stats. Identities = 105/439 (23%), Positives = 188/439 (42%), Gaps = 28/439 (6%) Query: 76 DGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIA---EDEEWKRLRSL 132 G +L + + K +L+K+ R + IA WK R + Sbjct: 1 MGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKM 60 Query: 133 LSPT---FTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSF 189 + F G + + II + + L + V L +V+ + F Sbjct: 61 VHGALCMFGEGSV-SIEKIICREASSMCEVLTESQNSA--VDLGPELTRAVTNVVCALCF 117 Query: 190 GVNIDSLNNPQDPFVENTKKLLR---FDFLDPFFLSITVFPFLIPILEVLNICVFPREVT 246 + + + ++ ++ ++ D L F + +FP L +L C+ R+ Sbjct: 118 NSSYKRGDAEFESMLQYSQGIVDTVAKDSLVDIFPWLQIFPNKD--LTILRQCISIRD-- 173 Query: 247 NFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKA----LSDLELVAQSIIF 302 L+K + K + ++ Q+ D L ++ ++ S E + L++ ++ Sbjct: 174 KLLQKKYEEHKVTYSDNVQR---DLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDI 230 Query: 303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 362 AG ETT++VL + + L +P VQ+K+QEE+D+ + + P + YL+ + E Sbjct: 231 FGAGVETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIRE 290 Query: 363 TLRLFPI-AMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421 LR+ P+ + + V +D + + KG V+I ++LH D K W PE F P RF Sbjct: 291 VLRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLN 350 Query: 422 KNKDNI--DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK-PCKETQIPLKLS 478 + D + Y PFG+G R C+G A M + L L +LQ F+ + P + L+ Sbjct: 351 EEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGK 410 Query: 479 LGGLLQPEK-PVVLKVESR 496 G +LQP+K VV KV + Sbjct: 411 FGVVLQPKKFKVVAKVRAD 429 >3DL9-A nrPDB Length = 479 Score = 311 bits (797), Expect = 4e-85, Method: Composition-based stats. Identities = 105/448 (23%), Positives = 182/448 (40%), Gaps = 16/448 (3%) Query: 57 FCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPV---GF 113 ++ + + YG+++ G + + D++K LV + +F +R Sbjct: 36 PHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQ-SEIFADRPCLPLFMKMTK 94 Query: 114 MKSAISIAEDEEWKRLRSLLSPTFTSGKL--KEMVPIIAQYGDVLVRNLRREAETGKPVT 171 M ++ W R L +F K I + + G+P Sbjct: 95 MGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIE--TYKGRPFD 152 Query: 172 LKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPF--L 229 K + ++ FG + +E + + FL FP+ + Sbjct: 153 FKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFL-YNAFPWIGI 211 Query: 230 IPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKA 289 +P + + V +FL + +++ +R +H VD +D + + + Sbjct: 212 LPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVD---AYLDEMDQGKNDPSST 268 Query: 290 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 349 S L+ I AG ETT++VL + + +A +P++Q ++Q+EID ++ P++D Sbjct: 269 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 328 Query: 350 VLQMEYLDMVVNETLRLFPIAM-RLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYW 408 +M Y + V++E LR I + +D + G IPKG V+ Y++H D KYW Sbjct: 329 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 388 Query: 409 TEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPC 468 +PE F PERF + PF G R+C+G A M M L +LQ F Sbjct: 389 RDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFP 448 Query: 469 KETQIPLKLSLGGLLQPEKPVVLKVESR 496 E LK LG LQP+ P ++ E R Sbjct: 449 HELVPDLKPRLGMTLQPQ-PYLICAERR 475 >5YLW-A nrPDB Length = 495 Score = 311 bits (797), Expect = 5e-85, Method: Composition-based stats. Identities = 107/453 (23%), Positives = 199/453 (43%), Gaps = 32/453 (7%) Query: 39 PGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKEC 98 PGP P P +GN+L + K+YG + + G + ++ P+M K +L + Sbjct: 30 PGPFPYPIVGNMLQLGANPHQVFAKLSKRYGPLMSIHLGSLYTVIVSSPEMAKEILHRHG 89 Query: 99 YSVFTNRRPFGPVGFMK-SAISIAEDE---EWKRLRSLLSPT-FTSGKLKEMVPIIAQYG 153 VF+ R V IS+ EW+ +R + F++ ++ + Q Sbjct: 90 -QVFSGRTIAQAVHACDHDKISMGFLPVASEWRDMRKICKEQMFSNQSMEASQGLRRQKL 148 Query: 154 DVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRF 213 L+ ++++ +++G+ V +++ +++++++T F ++ K + F Sbjct: 149 QQLLDHVQKCSDSGRAVDIREAAFITTLNLMSATLFSSQATEFDS---------KATMEF 199 Query: 214 DFLDPFFLSITVFPFL---IPILEVLNICVFPREVTNFLRKSV--------KRMKESRLE 262 + +I P PIL + R F K + +R++ R Sbjct: 200 KEIIEGVATIVGVPNFADYFPILRPFDPQGVKRRADVFFGKLLAKIEGYLNERLESKRAN 259 Query: 263 DTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELA 322 + DFL++++D + E + L + G +T ++ + + M EL Sbjct: 260 PNAPKKDDFLEIVVDIIQANEFK----LKTHHFTHLMLDLFVGGSDTNTTSIEWAMSELV 315 Query: 323 THPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPI-AMRLERVCKKDV 381 +PD +L+ E+ +V ++ + ++ YL V+ E +R+ P + L R + D Sbjct: 316 MNPDKMARLKAELKSVAGDEKIVDESAMPKLPYLQAVIKEVMRIHPPGPLLLPRKAESDQ 375 Query: 382 EINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP-YIYTPFGSGPR 440 E+NG IPKG ++I +YA+ RDP WT+PE F PERF D Y PFGSG R Sbjct: 376 EVNGYLIPKGTQILINAYAIGRDPSIWTDPETFDPERFLDNKIDFKGQDYELLPFGSGRR 435 Query: 441 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQI 473 C GM A + +A ++ NF +K ++ Sbjct: 436 VCPGMPLATRILHMATATLVHNFDWKLEDDSTA 468 >3JUS-A nrPDB Length = 461 Score = 310 bits (794), Expect = 8e-85, Method: Composition-based stats. Identities = 106/465 (22%), Positives = 188/465 (40%), Gaps = 37/465 (7%) Query: 42 TPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMI--------KTV 93 +P+PFLG+ +++ K F ++KYG V+ F + + D + + Sbjct: 18 SPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDL 77 Query: 94 LVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYG 153 ++ YS T F K + + + +L K+ V II + Sbjct: 78 NAEDVYSRLTTPV------FGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKET 131 Query: 154 DVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRF 213 + E K+VF A S +I + S ++ + + + V L Sbjct: 132 KEYFESWGESGE-------KNVFEALSELIILTASHCLHGKEIRSQLNEKVAQ----LYA 180 Query: 214 DFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQ 273 D F + + P +P+ RE+ + K++++ ++S Q+ D LQ Sbjct: 181 DLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQS-----QEKIDDILQ 235 Query: 274 LMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQE 333 ++D+ + L+D E+ I + AG T+S+ +++ + LA +Q+K Sbjct: 236 TLLDATYK----DGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYL 291 Query: 334 EIDAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGV 392 E V PP TYD + + LD + ETLRL P M + R+ + + G IP G Sbjct: 292 EQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGH 351 Query: 393 VVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNM 452 V + R W E F P+R+ + N + + + Y PFG+G CIG FA + + Sbjct: 352 QVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQI 411 Query: 453 KLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRD 497 K +L+ + F P + PE P V++ + R Sbjct: 412 KTIWSTMLRLYEFDLIDGY-FPTVNYTTMIHTPENP-VIRYKRRS 454 >5VBU-A nrPDB Length = 476 Score = 307 bits (786), Expect = 7e-84, Method: Composition-based stats. Identities = 99/465 (21%), Positives = 196/465 (42%), Gaps = 20/465 (4%) Query: 41 PTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYS 100 P P ++L ++ + +K+G ++ + G Q V+ + I+ +VK+ Sbjct: 12 PPLAPGFLHLLQ--PDLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWAD 69 Query: 101 VFTNRRPF--GPVGFMKSAISIAEDEE-WKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLV 157 P V +S+ + WK + L G M P++ Q Sbjct: 70 FAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFC 129 Query: 158 RNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR-FDFL 216 +R A+ G PV +++ F + +I +FG I +N + + +++L+ + Sbjct: 130 ERMR--AQPGTPVAIEEEFSLLTCSIICYLTFGDKIKD-DNLMPAYYKCIQEVLKTWSHW 186 Query: 217 DPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMI 276 + + F P + + + + + +++ KES + + +D++ + Sbjct: 187 SIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYM--LQ 244 Query: 277 DSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEID 336 E L + + ++ + G ETT++ LS+ + L HP++QQ+LQEE+D Sbjct: 245 GVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELD 304 Query: 337 AVLPNKAPPT---YDTVLQMEYLDMVVNETLRLFPIAM-RLERVCKKDVEINGMFIPKGV 392 L A + Y ++ L+ + E LRL P+ L + I+G IP+G Sbjct: 305 HELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGT 364 Query: 393 VVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNM 452 V++ H D W P +F P+RF + K++ FG G R C+G A + + Sbjct: 365 VIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNS----RALAFGCGARVCLGEPLARLEL 420 Query: 453 KLALIRVLQNFSFKPCKETQIPLK-LSLGGLLQPEKPVVLKVESR 496 + L R+LQ F+ P + L+ L ++ +P ++++ R Sbjct: 421 FVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPR 465 >6AYB-A nrPDB Length = 466 Score = 306 bits (783), Expect = 2e-83, Method: Composition-based stats. Identities = 99/460 (21%), Positives = 196/460 (42%), Gaps = 20/460 (4%) Query: 41 PTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLV--KEC 98 P +P++G+ +S+ K F ++ KKYG V+ + + + P ++ T Sbjct: 16 PNLIPYVGSFVSFAKNPVQFIIDNSKKYGDVFTATILGKEMTFLNHPKILDTFFKATDNE 75 Query: 99 YSVFTNRRPFGPVGFMKSAISIAED-EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLV 157 S+ R PV F + A+ E +S T+ + + V I V Sbjct: 76 LSLRDVYRFMRPV-FGTGVVYDADSTERMMEQVKFVSSGLTTARFRVFVDIFEDEIAHKV 134 Query: 158 RNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLD 217 + L E DV + +I + S + D + E L D D Sbjct: 135 KELGPEGT-------VDVAELMADLIIFTASRCLLGDEVRQY---LSEKNLGKLYHDIDD 184 Query: 218 PFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMID 277 I+ F P L + V ++ + + +E + ++ + ++D Sbjct: 185 ----GISPLSFFYPSLPAPKRDKARKAVGEIFQELLDKRREEHKKHPERLLDESKMDVVD 240 Query: 278 SQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDA 337 +++ + + L+D+ + I +FAG T+S S+ + + ++ V +K+++E + Sbjct: 241 HLLTQKYKDGQELTDVHRIGILIAGLFAGQHTSSITSSWTLMNVISNKKVLEKVRKEQEE 300 Query: 338 VLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIP 397 ++ + YD V++M+YL+ + E LR++P + + R+ +K E IPKG ++++ Sbjct: 301 IMGSDKVLDYDKVMKMDYLEACMKEALRMYPPLIMIMRMARKPRECEQYIIPKGNILVVS 360 Query: 398 SYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALI 457 R +T P+ F PER +++ + Y PFG+G CIG FAL+ +K + Sbjct: 361 PSVAGRCTDTYTNPDVFDPERLTERKEHEKFKYGAVPFGAGRHKCIGENFALLQVKSIIS 420 Query: 458 RVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRD 497 +L+ F + + P SL ++ P P ++ + R Sbjct: 421 ILLRYFDMEYIGKIPDPSYTSL--VVGPSPPTRMRYKLRK 458 >4WMZ-A nrPDB Length = 539 Score = 301 bits (771), Expect = 4e-82, Method: Composition-based stats. Identities = 94/487 (19%), Positives = 169/487 (34%), Gaps = 46/487 (9%) Query: 39 PGPTPL-PFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPD--------M 89 P P++G+ + Y F EC KKYG ++ F + + P Sbjct: 57 PLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAK 116 Query: 90 IKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPII 149 + V + Y+ T F K I + + + T K VP+I Sbjct: 117 LADVSAEAAYAHLTTPV------FGKGVIYDCPNSRLMEQKKFVKGALTKEAFKSYVPLI 170 Query: 150 AQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKK 209 A+ R+ + + DV I + S + + D T Sbjct: 171 AEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKLD-----TDF 225 Query: 210 LLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRV 269 + LD F I +P+ + ++ +K + ++ Sbjct: 226 AYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIKERR----KNNDIQDR 281 Query: 270 DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQ 329 D + ++ + + ++D E+ I + G T+++ ++I+ LA PDVQQ Sbjct: 282 DLIDSLM---KNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERPDVQQ 338 Query: 330 KLQEEIDAVL-PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI--NGM 386 +L EE VL K TYD + +M L+ + ETLR+ L R KD+ + Sbjct: 339 ELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSY 398 Query: 387 FIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID----------------PY 430 IP G V++ H +Y+ +F R++ + + Sbjct: 399 VIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVSS 458 Query: 431 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVV 490 Y PFG G CIG FA + + + ++ + + +P + P P Sbjct: 459 PYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTSMVTLPTGPAK 518 Query: 491 LKVESRD 497 + E R+ Sbjct: 519 IIWEKRN 525 >5JLC-A nrPDB Length = 515 Score = 299 bits (765), Expect = 2e-81, Method: Composition-based stats. Identities = 93/488 (19%), Positives = 170/488 (34%), Gaps = 48/488 (9%) Query: 39 PGPTPL-PFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPD--------M 89 P P++G+ + Y F +C KKYG ++ F + + P Sbjct: 39 PLVFYWIPWVGSAIPYGTKPYEFFEDCQKKYGDIFSFMLLGRIMTVYLGPKGHEFIFNAK 98 Query: 90 IKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPII 149 + V + YS T F K I + + + T VP+I Sbjct: 99 LADVSAEAAYSHLTTPV------FGKGVIYDCPNHRLMEQKKFVKGALTKEAFVRYVPLI 152 Query: 150 AQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKK 209 A+ RN + + DV + I + S + + + D T Sbjct: 153 AEEIYKYFRNSKNFKINENNSGIVDVMVSQPEMTIFTASRSLLGKEMRDKLD-----TDF 207 Query: 210 LLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRV 269 + LD F I +P+ + ++ +K +E + Sbjct: 208 AYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQQAISGTYMSLIKERREKNDIQNR---- 263 Query: 270 DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQ 329 D + ++ + + ++D E+ I + G T+++ ++ + LA PDVQ+ Sbjct: 264 DLIDELM---KNSTYKDGTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERPDVQE 320 Query: 330 KLQEEIDAVLPNK-APPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI--NGM 386 +L +E VL N TYD + M L+ ++ ETLRL L R +DV I Sbjct: 321 ELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPLHSLFRKVMRDVAIPNTSY 380 Query: 387 FIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID-----------------P 429 +P+ V++ H +++ +P +F R+ + Sbjct: 381 VVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDYGFGAISKGVS 440 Query: 430 YIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK-PCKETQIPLKLSLGGLLQPEKP 488 Y PFG G CIG FA + + + ++ ++ P + +P + P P Sbjct: 441 SPYLPFGGGRHRCIGELFAYCQLGVLMSIFIRTMKWRYPTEGETVPPSDFTSMVTLPTAP 500 Query: 489 VVLKVESR 496 + E R Sbjct: 501 AKIYWEKR 508 >3MDV-A nrPDB Length = 456 Score = 295 bits (755), Expect = 3e-80, Method: Composition-based stats. Identities = 105/450 (23%), Positives = 208/450 (46%), Gaps = 24/450 (5%) Query: 54 HKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTN-----RRPF 108 + ++ KKYG V + + +T P+ +K L+ Y+ + + F Sbjct: 9 GRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVF 68 Query: 109 GPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGK 168 G F + +S E W + R ++ F+ L ++ + + LV L +A+ Sbjct: 69 GERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQT 128 Query: 169 PVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPF 228 PV+++D+ +MD++ +FG+ L Q P + K +L + S Sbjct: 129 PVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLML-----EGITASRNTLAK 183 Query: 229 LIPILE--VLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETES 286 +P + + R + R V+R +E+ L+ ++ D L ++ ++ + Sbjct: 184 FLPGKRKQLREVRESIRFLRQVGRDWVQRRREA-LKRGEEVPADILTQILKAEEGAQ--- 239 Query: 287 HKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT 346 D L+ + F AG+ET+++ L+F + EL+ P++ +LQ E+D V+ +K Sbjct: 240 ----DDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLD 295 Query: 347 YDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPK 406 ++ + +++YL V+ E+LRL+P A R+ +++ I+G+ +P ++ +Y + R Sbjct: 296 FEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDT 355 Query: 407 YWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK 466 Y+ +P F P+RF + Y PF G R+CIG +FA M +K+ + ++LQ F+ Sbjct: 356 YFEDPLTFNPDRFGP--GAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFR 413 Query: 467 PCKETQIPLKLSLGGLLQPEKPVVLKVESR 496 + L+ L+P PV+ + R Sbjct: 414 LVPGQRFGLQEQ--ATLKPLDPVLCTLRPR 441 >6IQ5-A nrPDB Length = 463 Score = 295 bits (754), Expect = 4e-80, Method: Composition-based stats. Identities = 97/448 (21%), Positives = 171/448 (38%), Gaps = 23/448 (5%) Query: 58 CMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSA 117 + ++YG V+ G P++ + I LV++ S F +R F + Sbjct: 4 HLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQG-SAFADRPSFASFRVVSGG 62 Query: 118 ISIAED---EEWKRLRS----LLSPTFTS--GKLKEMVPIIAQYGDVLVRNLRREAETGK 168 S+A E WK R ++ FT + + + LV L R + G Sbjct: 63 RSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGA 122 Query: 169 PVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPF 228 + + + +V+++ FG + F E F + V P+ Sbjct: 123 FLDPRPLTVVAVANVMSAVCFGCRYS---HDDPEFRELLSHNEEFGRTVGAGSLVDVMPW 179 Query: 229 LI----PILEVLN-ICVFPREVTNFLRKSVKRMKES-RLEDTQKHRVDFLQLMIDSQNSK 282 L P+ V R +NF+ R ES R + +D L + + + Sbjct: 180 LQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAG 239 Query: 283 ETESHKALSDLELVAQSIIFIF-AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN 341 ++ A DLE V +I IF A +T S+ L +++ +PDVQ ++Q E+D V+ Sbjct: 240 DSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGR 299 Query: 342 KAPPTYDTVLQMEYLDMVVNETLRLFP-IAMRLERVCKKDVEINGMFIPKGVVVMIPSYA 400 P + Y+ + E +R + + + + + G IPK VV + ++ Sbjct: 300 DRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWS 359 Query: 401 LHRDPKYWTEPEKFLPERFSKKNK--DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIR 458 ++ DP W PE F P RF K+ + F G R CIG + M + L + Sbjct: 360 VNHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISI 419 Query: 459 VLQNFSFKPCKETQIPLKLSLGGLLQPE 486 + F+ + S G ++P+ Sbjct: 420 LAHQCDFRANPNEPAKMNFSYGLTIKPK 447 >6CR2-A nrPDB Length = 477 Score = 291 bits (744), Expect = 5e-79, Method: Composition-based stats. Identities = 98/481 (20%), Positives = 181/481 (37%), Gaps = 49/481 (10%) Query: 44 LPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPD--------MIKTVLV 95 PF+G+ +SY F +C KYG ++ F + ++ V Sbjct: 13 FPFIGSTISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTVYLGTKGNDFILNGKLRDVCA 72 Query: 96 KECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDV 155 +E YS T F + + + + + + TS L+ VP+I + Sbjct: 73 EEVYSPLTTPV------FGRHVVYDCPNAKLMEQKKFVKYGLTSDALRSYVPLITDEVES 126 Query: 156 LVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDF 215 V+N A G + DV + I + S + + + D + Sbjct: 127 FVKN--SPAFQGHK-GVFDVCKTIAEITIYTASRSLQGKEVRSKFDSTFAEL-----YHN 178 Query: 216 LDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLM 275 LD F I P+ R++T + +K +++ ++K D + + Sbjct: 179 LDMGFAPINFMLPWAPLPHNRKRDAAQRKLTETYMEIIKARRQA---GSKKDSEDMVWNL 235 Query: 276 IDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI 335 + + + D E+ I + AG ++SS S+I+ LAT PD+ ++L +E Sbjct: 236 MSCVYK----NGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQ 291 Query: 336 DAVLPNKAPP-TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEING--MFIPKGV 392 VL + PP TYD + +++ V+ ETLRL + R K + ++G IP Sbjct: 292 IRVLGSDLPPLTYDNLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSH 351 Query: 393 VVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY----------------IYTPFG 436 V+ R +++ P ++ P R+ + + + Y PFG Sbjct: 352 NVLSSPGVTARSEEHFPNPLEWNPHRWDENIAASAEDDEKVDYGYGLVSKGTNSPYLPFG 411 Query: 437 SGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ-IPLKLSLGGLLQPEKPVVLKVES 495 +G CIG +FA + + +++ F F+ IP +P ++ E Sbjct: 412 AGRHRCIGEQFAYLQLGTITAVLVRLFRFRNLPGVDGIPDTDYSSLFSKPLGRSFVEFEK 471 Query: 496 R 496 R Sbjct: 472 R 472 >6C94-A nrPDB Length = 497 Score = 288 bits (738), Expect = 3e-78, Method: Composition-based stats. Identities = 126/474 (26%), Positives = 222/474 (46%), Gaps = 29/474 (6%) Query: 37 GIPGPTPLPFLGNILSYHK-GFCMFDMECHKKYGKVWGFYDGQQP-VLAITDPDMIKTVL 94 PGP G+ L K G + +++ + GQ L I +PD K V Sbjct: 23 SFPGPPTHWLFGHALEIQKTGSLDKVVTWTQQFPYAHPLWVGQFIGFLNIYEPDYAKAVY 82 Query: 95 VK------ECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPI 148 + + Y F + ++ + + + +W + R LL+P F LK V I Sbjct: 83 SRGDPKAPDVYDFF--------LQWIGKGLLVLDGPKWFQHRKLLTPGFHYDVLKPYVAI 134 Query: 149 IAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTK 208 A +++ ++A GK + G ++D + +FG LN+ + Sbjct: 135 FADSTRIMLEKWEKKACEGKSFDIFSDVGHMALDTLMKCTFGKGDSGLNHRDSSYYVAVS 194 Query: 209 KL--LRFDFLDPFFLSITVFPFLIPI-LEVLNICVFPREVTNFL---RKSVKRMKESRLE 262 +L L +D F +L P L C + T+ + RK+ + ++ R + Sbjct: 195 ELTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACRAAHDHTDRVIRQRKAALQDEKEREK 254 Query: 263 DTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELA 322 + +DFL +++D + ES LSD +L A+ F+F G++TT+S +S+ +Y +A Sbjct: 255 IQNRRHLDFLDILLDVR----GESGVQLSDTDLRAEVDTFMFEGHDTTTSGISWFLYCMA 310 Query: 323 THPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVE 382 +P+ QQ+ +EE+ +L ++ ++ + +M YL M + E RL+P ++ R K V Sbjct: 311 LYPEHQQRCREEVREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQVYRQLSKPVS 370 Query: 383 -INGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441 ++G +P G ++ + YALHR+ W +PE F P RFS +N PY + PF +GPRN Sbjct: 371 FVDGRSLPAGSLISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRHPYAFIPFSAGPRN 430 Query: 442 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVES 495 CIG +FA+ MK+ L F F ++P+KL +L+ + + L ++ Sbjct: 431 CIGQQFAMNEMKVVTALCLLRFEFS-VDPLRLPIKLPQ-LVLRSKNGIHLYLKP 482 >5FSA-A nrPDB Length = 490 Score = 287 bits (734), Expect = 8e-78, Method: Composition-based stats. Identities = 90/494 (18%), Positives = 163/494 (32%), Gaps = 53/494 (10%) Query: 39 PGPTPL-PFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPD--------M 89 P P+ G+ SY + F C +KYG V+ F + + P Sbjct: 7 PLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHEFVFNAK 66 Query: 90 IKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPII 149 + V +E Y T F I + + T+ K VP I Sbjct: 67 LSDVSAEEAYKHLTTPV------FGTGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVPKI 120 Query: 150 AQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKK 209 + K + +V I + S + D + D Sbjct: 121 REEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDR-----SF 175 Query: 210 LLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRV 269 + LD F I +P+ ++++ K +K +E D + + Sbjct: 176 AQLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKLRRERGDIDPNRDLI 235 Query: 270 DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQ 329 D L+I S ++D E+ I + G T++S ++ + L P +Q Sbjct: 236 D--SLLIHSTYK----DGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQD 289 Query: 330 KLQEEIDAVL----PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI-- 383 + +E+ +L + TY+ + ++ ++ + ETLR+ + R + I Sbjct: 290 VIYQEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPE 349 Query: 384 NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID--------------- 428 +PKG V++ H +Y+ PE F P R+ Sbjct: 350 TNYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFGK 409 Query: 429 -----PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLL 483 Y PFG G CIG +FA + + L + N + ++P ++ Sbjct: 410 VSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRW-TIDGYKVPDPDYSSMVV 468 Query: 484 QPEKPVVLKVESRD 497 P +P + E R+ Sbjct: 469 LPTEPAEIIWEKRE 482 >3K9V-A nrPDB Length = 482 Score = 277 bits (709), Expect = 7e-75, Method: Composition-based stats. Identities = 120/479 (25%), Positives = 202/479 (42%), Gaps = 42/479 (8%) Query: 38 IPGPTPLPFLGNILS-YHKGFCMF----DMECHKKYGKVWGFYDGQQPVLAITDPDMIKT 92 +PGPT P LG++L + KG E HKKYG+++ G + + P +++ Sbjct: 26 LPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLGSFDSVHLGSPSLLEA 85 Query: 93 VLVKECYSVFTNRRPFGPVGFMKS------AISIAEDEEWKRLRSLLSPTFTSGKLKEMV 146 + E S R P + + I E +EW+R+RS K E++ Sbjct: 86 LYRTE--SAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRSAFQKKLM--KPVEIM 141 Query: 147 PIIAQYGDVLVRNLRR----EAETGKPVTLKDVFGAYSMDVITSTS----FGVNIDSLNN 198 + + +VL L R E G+ L +S + I FG+ Sbjct: 142 KLDKKINEVLADFLERMDELCDERGRIPDLYSELNKWSFESICLVLYEKRFGLLQKETEE 201 Query: 199 PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKE 258 F+ K ++ F + V P + + + + KSVK + Sbjct: 202 EALTFITAIKTMM------STFGKMMVTPVELHKRLNTKVWQAHTLAWDTIFKSVKPCID 255 Query: 259 SRLED-TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFI 317 +RL+ +Q+ DFL + LS EL A A ETT++ L +I Sbjct: 256 NRLQRYSQQPGADFLCDIYQQ---------DHLSKKELYAAVTELQLAAVETTANSLMWI 306 Query: 318 MYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVC 377 +Y L+ +P Q++L +E+ +VLP+ P + + M YL + E++RL P R Sbjct: 307 LYNLSRNPQAQRRLLQEVQSVLPDNQTPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTL 366 Query: 378 KKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGS 437 K + +PKG V+ + + L + + KF PER+ +K K I+P+ + PFG Sbjct: 367 DKPTVLGEYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQKEK-KINPFAHLPFGI 425 Query: 438 GPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESR 496 G R CIG R A + + LAL ++Q + P+++ G+L P + + + R Sbjct: 426 GKRMCIGRRLAELQLHLALCWIIQKYDIVATDNE--PVEMLHLGILVPSRELPIAFRPR 482 >3TBG-A nrPDB Length = 479 Score = 275 bits (704), Expect = 2e-74, Method: Composition-based stats. Identities = 88/447 (19%), Positives = 166/447 (37%), Gaps = 18/447 (4%) Query: 61 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSA--- 117 + +++G V+ PV+ + ++ LV +R P + Sbjct: 36 FDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDT-ADRPPVPITQILGFGPRS 94 Query: 118 ---ISIAEDEEWKRLRSLLSPTFTSGKL--KEMVPIIAQYGDVLVRNLRREAETGKPVTL 172 W+ R T + L K + + + L +G+P Sbjct: 95 QGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFAN--HSGRPFRP 152 Query: 173 KDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPI 232 + +VI S + G + + ++ ++ L+ + + P L+ I Sbjct: 153 NGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLK-EESGFLREVLNAVPVLLHI 211 Query: 233 LEVL-NICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALS 291 + + F + L + + + + D + D + + + + + Sbjct: 212 PALAGKVLRFQKAFLTQLDELLTEHRMTW--DPAQPPRDLTEAFLAEMEKAKGNPESSFN 269 Query: 292 DLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL 351 D L AG TTS+ L++ + + HPDVQ+++Q+EID V+ P Sbjct: 270 DENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQA 329 Query: 352 QMEYLDMVVNETLRLFPIAM-RLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTE 410 M Y V++E R I + + +D+E+ G IPKG ++ ++ +D W + Sbjct: 330 HMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEK 389 Query: 411 PEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFK-PCK 469 P +F PE F + P + PF +G R C+G A M + L +LQ+FSF P Sbjct: 390 PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG 449 Query: 470 ETQIPLKLSLGGLLQPEKPVVLKVESR 496 + + L+ P P L R Sbjct: 450 QPRPSHHGVFAFLVSPS-PYELCAVPR 475 >2WX2-A nrPDB Length = 473 Score = 275 bits (702), Expect = 4e-74, Method: Composition-based stats. Identities = 93/467 (19%), Positives = 172/467 (36%), Gaps = 30/467 (6%) Query: 41 PTPLPFLGNILSYHKGFCMFDMECHKKY-GKVWGFYDGQQPVLAITDPDMIKTVLV--KE 97 P +PFLG+I+ + K F C + V+ G Q V + DP E Sbjct: 22 PVTVPFLGHIVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSRFFSPRNE 81 Query: 98 CYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGD-VL 156 S PV F + A + + L+ T K + VP I + Sbjct: 82 ILSPREVYTIMTPV-FGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFM 140 Query: 157 VRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFL 216 N E + L + GA ++ FG ++ N + F + K+ Sbjct: 141 AENW---KEDEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARH-FAQLLSKME----- 191 Query: 217 DPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMI 276 + P+L+ + L RE L+K + + +R E + + + ++ Sbjct: 192 SSLIPAAVFMPWLLRLP--LPQSARCREARAELQKILGEIIVAR-EKEEASKDNNTSDLL 248 Query: 277 DSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELAT--HPDVQQKLQEE 334 +S E+ + +FAG T++ S+ M L + KL +E Sbjct: 249 GGLLKAVYRDGTRMSLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKE 308 Query: 335 IDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVV 394 ID +M + + V E++R P + + R+ K +V++ +PKG ++ Sbjct: 309 IDEFPAQLNYDNVMD--EMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDII 366 Query: 395 MIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKL 454 H D + + P + PER K + + FG+G CIG +FAL+ +K Sbjct: 367 ACSPLLSHHDEEAFPNPRLWDPERDEKVDG------AFIGFGAGVHKCIGQKFALLQVKT 420 Query: 455 ALIRVLQNFSFKPCKETQIPLKLSLGGLLQP--EKPVVLKVESRDGT 499 L + + F+ ++ ++P ++ P + +V + Sbjct: 421 ILATAFREYDFQLLRD-EVPDPDYHTMVVGPTLNQCLVKYTRKKKLP 466 >4KPA-A nrPDB Length = 494 Score = 255 bits (651), Expect = 3e-68, Method: Composition-based stats. Identities = 117/470 (24%), Positives = 206/470 (43%), Gaps = 22/470 (4%) Query: 38 IPGPTPLPFLGNILSYHKG-FCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVK 96 +P P L N+ + M+ + G+++ F + ++ +IK + Sbjct: 29 MPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDE 88 Query: 97 ECYSVFTNRRPFGPVGFMKSAI--SIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGD 154 + ++ F + S ++ WK+ ++L P+F+ +K ++ Sbjct: 89 SRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAV 148 Query: 155 VLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFD 214 LV+ R + + + + ++D I F +S Q + + Sbjct: 149 QLVQKWERL-NADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDE 207 Query: 215 FLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQL 274 ++ + P + + + + + K + K S + D L Sbjct: 208 AMNKLQRANPDDPAYDENKRQFQEDI--KVMNDLVDKIIADRKAS-----GEQSDDLLTH 260 Query: 275 MIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEE 334 M+ N K+ E+ + L D + Q I F+ AG+ETTS +LSF +Y L +P V QK EE Sbjct: 261 ML---NGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEE 317 Query: 335 IDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEING-MFIPKGVV 393 VL + P+Y V Q++Y+ MV+NE LRL+P A K+D + G + KG Sbjct: 318 AARVLVDPV-PSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDE 376 Query: 394 VMIPSYALHRDPKYW-TEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNM 452 +M+ LHRD W + E+F PERF +N I + + PFG+G R CIG +FAL Sbjct: 377 LMVLIPQLHRDKTIWGDDVEEFRPERF--ENPSAIPQHAFKPFGNGQRACIGQQFALHEA 434 Query: 453 KLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSG 502 L L +L++F F+ ++ +K +L L+PE V+K +S+ + G Sbjct: 435 TLVLGMMLKHFDFEDHTNYELDIKETL--TLKPEG-FVVKAKSKKIPLGG 481 >2X2N-A nrPDB Length = 475 Score = 252 bits (643), Expect = 3e-67, Method: Composition-based stats. Identities = 86/468 (18%), Positives = 172/468 (36%), Gaps = 37/468 (7%) Query: 41 PTPLPFLGNILSYHKGFCMFDMECHKKY-GKVWGFYDGQQPVLAITDPDMIKTVLV--KE 97 P +P LG+I+ + K F EC ++ ++ + V + DP + E Sbjct: 22 PVTVPILGHIIQFGKSPLGFMQECKRQLKSGIFTINIVGKRVTIVGDPHEHSRFFLPRNE 81 Query: 98 CYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGD-VL 156 S PV F + A + + L+ T K + VP I + Sbjct: 82 VLSPREVYSFMVPV-FGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFM 140 Query: 157 VRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFL 216 N ++ + L + ++ FG ++ + + F + K+ Sbjct: 141 AANWDKDE---GEINLLEDCSTMIINTACQCLFGEDLRKRLDAR-RFAQLLAKM------ 190 Query: 217 DPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRM---KESRLEDTQKHRVDFLQ 273 + + VF ++ L + E L+K + + +++ + D L Sbjct: 191 ESSLIPAAVFLPILLKLPLPQSARCH-EARTELQKILSEIIIARKAAAVNKDSSTSDLLS 249 Query: 274 LMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHP---DVQQK 330 ++ + +S E+ + +FAG T+S ++ M L HP + Sbjct: 250 GLLSAVYR----DGTPMSLHEVCGMIVAAMFAGQHTSSITTTWSMLHLM-HPANVKHLEA 304 Query: 331 LQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPK 390 L++EI+ +M + + E++R P + L R DV++ +PK Sbjct: 305 LRKEIEEFPAQLNYNNVMD--EMPFAERCARESIRRDPPLLMLMRKVMADVKVGSYVVPK 362 Query: 391 GVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALM 450 G ++ H D + + EP ++ PER K + FG+G CIG +F L+ Sbjct: 363 GDIIACSPLLSHHDEEAFPEPRRWDPERDEKVEG------AFIGFGAGVHKCIGQKFGLL 416 Query: 451 NMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPV-VLKVESRD 497 +K L +++ F+ ++ ++P ++ P +K R Sbjct: 417 QVKTILATAFRSYDFQLLRD-EVPDPDYHTMVVGPTASQCRVKYIRRK 463 >3L4D-A nrPDB Length = 453 Score = 251 bits (640), Expect = 6e-67, Method: Composition-based stats. Identities = 83/450 (18%), Positives = 169/450 (37%), Gaps = 33/450 (7%) Query: 45 PFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVL--VKECYSVF 102 PF+G+I+ + K F ++ KKYG ++ + + D E S Sbjct: 13 PFVGHIIQFGKDPLGFMLKAKKKYGGIFTMNICGNRITVVGDVHQHSKFFTPRNEILSPR 72 Query: 103 TNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVR-NLR 161 PV F + A + + L+ T K + P I ++ N Sbjct: 73 EVYSFMVPV-FGEGVAYAAPYPRMREQLNFLAEELTVAKFQNFAPSIQHEVRKFMKANWN 131 Query: 162 REAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFL 221 ++ + + D A ++ FG ++ + + F + K+ Sbjct: 132 KDE---GEINILDDCSAMIINTACQCLFGEDLRKRLDARQ-FAQLLAKME-----SCLIP 182 Query: 222 SITVFPFLI--PILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQ 279 + P+++ P+ + E+ + L + + +E + D L ++ + Sbjct: 183 AAVFLPWILKLPLPQSYRCRDARAELQDILSEIIIA-REKEEAQKDTNTSDLLAGLLGAV 241 Query: 280 NSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELA--THPDVQQKLQEEIDA 337 +S E+ + +FAG T++ ++ + L + KL +EID Sbjct: 242 YR----DGTRMSQHEVCGMIVAAMFAGQHTSTITTTWSLLHLMDPRNKRHLAKLHQEIDE 297 Query: 338 VLPNKAPPTYDTVLQ-MEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMI 396 A YD V++ M + + E++R P + L R K V++ +P+G ++ Sbjct: 298 F---PAQLNYDNVMEEMPFAEQCARESIRRDPPLVMLMRKVLKPVQVGKYVVPEGDIIAC 354 Query: 397 PSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLAL 456 H+D + + P ++ PER + + FG+G CIG +F L+ +K L Sbjct: 355 SPLLSHQDEEAFPNPREWNPER-----NMKLVDGAFCGFGAGVHKCIGEKFGLLQVKTVL 409 Query: 457 IRVLQNFSFKPCKETQIPLKLSLGGLLQPE 486 VL+++ F+ +P ++ P Sbjct: 410 ATVLRDYDFELLG--PLPEPNYHTMVVGPT 437 >3S79-A nrPDB Length = 503 Score = 247 bits (630), Expect = 1e-65, Method: Composition-based stats. Identities = 85/441 (19%), Positives = 177/441 (40%), Gaps = 28/441 (6%) Query: 37 GIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWG-----FYDGQQPVLAITDPDMIK 91 IPGP +G ++S+ + M Y +V+G + G++ ++ M Sbjct: 46 SIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFH 105 Query: 92 TVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEE-WKRLRSLLSPTFTSGKLKEMVPIIA 150 + S F ++ +G + I + E WK R + L MV + A Sbjct: 106 IMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCA 165 Query: 151 QYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKL 210 + + L V + + +D N L P D K Sbjct: 166 ESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDT-------SNTLFLRIPLDESAIVVKIQ 218 Query: 211 LRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQ-KHRV 269 FD + +F + + + V +++ + + + + + + + + Sbjct: 219 GYFDAWQALLIKPDIFFKISWLYKKYEKSV--KDLKDAIEVLIAEKRRRISTEEKLEECM 276 Query: 270 DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQ 329 DF +I ++ + L+ + + + A +T S L F+++ +A HP+V++ Sbjct: 277 DFATELILAEKRGD------LTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEE 330 Query: 330 KLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIP 389 + +EI V+ + D + +++ ++ + E++R P+ + R +D I+G + Sbjct: 331 AIIKEIQTVIGERDIK-IDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVK 389 Query: 390 KGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFAL 449 KG +++ +HR ++ +P +F E F+K N+ + PFG GPR C G A+ Sbjct: 390 KGTNIILNIGRMHRLE-FFPKPNEFTLENFAK----NVPYRYFQPFGFGPRGCAGKYIAM 444 Query: 450 MNMKLALIRVLQNFSFKPCKE 470 + MK L+ +L+ F K + Sbjct: 445 VMMKAILVTLLRRFHVKTLQG 465 >2W0A-A nrPDB Length = 455 Score = 243 bits (621), Expect = 9e-65, Method: Composition-based stats. Identities = 87/456 (19%), Positives = 176/456 (38%), Gaps = 25/456 (5%) Query: 48 GNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRR- 106 G++ + + G V F + V+ ++ + + Sbjct: 17 GHLEEFRTDPIGLMQRVRDELGDVGTFQLAGKQVVLLSGSHA-NEFFFRAGDDDLDQAKA 75 Query: 107 -PFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAE 165 PF F ++ + A E K + L + ++K I ++ + E Sbjct: 76 YPFMTPIFGEAVVFDASPERRKEM--LHNAALRGEQMKGHAATIEDQVRRMIADWGEAGE 133 Query: 166 TGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITV 225 + L D F ++ ++ G + + + L+ + Sbjct: 134 ----IDLLDFFAELTIYTSSACLIGKKFRDQL--------DGRFAKLYHELERGTDPLAY 181 Query: 226 FPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETE 285 +PI E N L V + R+ + + D + M+D + + E Sbjct: 182 VDPYLPIESFRRRD----EARNGLVALVADIMNGRIANPPTDKSD--RDMLDVLIAVKAE 235 Query: 286 SHKA-LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAP 344 + S E+ I +FAG+ T+S S+ + EL H D + +E+D + + Sbjct: 236 TGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRS 295 Query: 345 PTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRD 404 ++ + Q+ L+ V+ ETLRL P + L RV K + E+ G I +G +V +R Sbjct: 296 VSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRI 355 Query: 405 PKYWTEPEKFLPERFS-KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 P+ + +P F+P R+ + +D ++ + + PFG+G C+G FA+M +K +L+ + Sbjct: 356 PEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREY 415 Query: 464 SFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGT 499 F+ + + ++Q +P ++ R G Sbjct: 416 EFEMAQPPESYRNDHSKMVVQLAQPAAVRYRRRTGV 451 >5VWS-A nrPDB Length = 393 Score = 240 bits (611), Expect = 2e-63, Method: Composition-based stats. Identities = 80/396 (20%), Positives = 149/396 (37%), Gaps = 63/396 (15%) Query: 70 KVWGFYDGQQPVLAITDPDMIKTVLVK-ECYSVFTNRRPFGPVGFMKSAISIAEDEEWKR 128 VW G + + D ++ +L + +S R GF K I++ + E + Sbjct: 32 PVWRDQFG---IYHVFRYDDVRQILGDYQTFSSDRTRLMPTAQGFGKGGITMIDPPEHRH 88 Query: 129 LRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTS 188 R L++ FT + M P I Q D L+ L G L + F ++ + Sbjct: 89 QRRLITHAFTPQSISAMEPRIRQIADHLLDEL-----PGPEFDLVEHFAYPLPVIVIAEL 143 Query: 189 FGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNF 248 GV + F +S+ V + P L + E+ ++ Sbjct: 144 LGVPPGDRH--------------LFRTWSDRLMSLQVENYADPEL-ARTVAAAMTEMNDY 188 Query: 249 LRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYE 308 LR+ + + R D L ++ ++ K L E+V + + + AG+ Sbjct: 189 LREHCRSRRTH-------PRDDLLTRLVQAEV-----EGKRLDLEEVVNTASLLLLAGHL 236 Query: 309 TTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP 368 TT+ ++ M L HP+ ++ ++ + + + E+LRL Sbjct: 237 TTTVLIGNTMLCLWDHPEAEKAVRAD------------------PSLIPAALEESLRLRS 278 Query: 369 IAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID 428 ++ RV +DV I G IP VM + + D + + +PE+F R + Sbjct: 279 PFLQAGRVTTRDVTIAGETIPANRFVMAWILSANHDDRRFPDPERFDLHRQTTG------ 332 Query: 429 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS 464 + FG G C+G + + ++AL R+L F+ Sbjct: 333 ---HIAFGHGVHFCLGAQLGRLEGRIALERLLGRFT 365 >2VE3-A nrPDB Length = 444 Score = 238 bits (608), Expect = 3e-63, Method: Composition-based stats. Identities = 96/438 (21%), Positives = 180/438 (41%), Gaps = 29/438 (6%) Query: 39 PGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKEC 98 PG LP+LG L++ F + +++G ++ + V+ I+ + + KE Sbjct: 15 PGDFGLPWLGETLNFLNDG-DFGKKRQQQFGPIFKTRLFGKNVIFISGALANRFLFTKEQ 73 Query: 99 YSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVR 158 + + +A++ E + R +L F L +P + + Sbjct: 74 ETFQATWPLSTRILLGPNALATQMGEIHRSRRKILYQAFLPRTLDSYLPKMDGIVQGYLE 133 Query: 159 NLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDP 218 + V + DV + G + + F + + Sbjct: 134 QWGK----ANEVIWYPQLRRMTFDVAATLFMGEKVS-------------QNPQLFPWFET 176 Query: 219 FFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDS 278 + + P +P + L K +K ++ D L +++ + Sbjct: 177 YIQGLFSLPIPLPNTLFGKSQRARALLLAELEKIIKARQQ-----QPPSEEDALGILLAA 231 Query: 279 QNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAV 338 ++ ++++ LS EL Q ++ +FAG+ET +S LS L H D+++++++E + + Sbjct: 232 RD----DNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDIRERVRQEQNKL 287 Query: 339 LPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPS 398 ++ T +T+ +M YLD V+ E LRL P R +D + G PKG +V Sbjct: 288 QLSQ-ELTAETLKKMPYLDQVLQEVLRLIPPVGGGFRELIQDCQFQGFHFPKGWLVSYQI 346 Query: 399 YALHRDPKYWTEPEKFLPERFS-KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALI 457 H DP + +PEKF PERF+ + + P+ + PFG G R C+G FA + MKL Sbjct: 347 SQTHADPDLYPDPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECLGKEFARLEMKLFAT 406 Query: 458 RVLQNFSFKPCKETQIPL 475 R++Q F + + L Sbjct: 407 RLIQQFDWTLLPGQNLEL 424 >4RM4-A nrPDB Length = 396 Score = 238 bits (607), Expect = 4e-63, Method: Composition-based stats. Identities = 80/442 (18%), Positives = 153/442 (34%), Gaps = 78/442 (17%) Query: 41 PTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYS 100 P P S K + E ++ VW + + D ++ + + ++ S Sbjct: 26 PFPW-----YESMRKDAPVSFDEENQ----VWSVFLYDDVKKVVGDKELFSSCMPQQTSS 76 Query: 101 VFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL 160 + ++I + + ++RS+++ FT +K+ P I + D L++ Sbjct: 77 -------------IGNSIINMDPPKHTKIRSVVNKAFTPRVMKQWEPRIQEITDELIQKF 123 Query: 161 RREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFF 220 + +E L F ++ S GV + + D Sbjct: 124 QGRSE----FDLVHDFSYPLPVIVISELLGVPSAHMEQ-------------FKAWSDLLV 166 Query: 221 LSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQN 280 + + E+ F ++ + K D + ++++++ Sbjct: 167 STPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKR-------NKPEQDIISILVEAEE 219 Query: 281 SKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLP 340 + E LS EL+ + + AG ETT++++S MY + P V ++L+ Sbjct: 220 TGEK-----LSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELR-------- 266 Query: 341 NKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYA 400 E + V E LR A L R+ K+D EI G I +G +V+ + Sbjct: 267 ----------SHPELMPQAVEEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVAS 316 Query: 401 LHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVL 460 +RD + P F R P + FG G C+G A + +AL ++ Sbjct: 317 ANRDEAKFDRPHMFDIRR---------HPNPHIAFGHGIHFCLGAPLARLEANIALTSLI 367 Query: 461 QNFSFKPCKETQIPLKLSLGGL 482 F C + GL Sbjct: 368 SAFPHMECVSITPIENSVIYGL 389 >5XNT-A nrPDB Length = 411 Score = 235 bits (600), Expect = 3e-62, Method: Composition-based stats. Identities = 90/430 (20%), Positives = 162/430 (37%), Gaps = 68/430 (15%) Query: 69 GKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKR 128 W + + ++D +V + SV T+ +K I+ A+ E ++ Sbjct: 41 TDTWNVFKYEDVKRVLSDYKHFSSVRKRTTISVGTDSEEGSVPDKIK--ITEADPPEHRK 98 Query: 129 LRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTS 188 RSLL+ FT L+ P I + D L+ + E E + + + ++ S Sbjct: 99 RRSLLAAAFTPRSLQNWEPRIQEIADELIEEMDEETE----IDIVQSLASPLPIIVMSDL 154 Query: 189 FGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLN--ICVFPREVT 246 GV +LL ++D FL PF E +N V +E Sbjct: 155 MGVPSK-------------DRLLFKKWVDILFL-----PFDKEKQEEVNELKQVAAKEYY 196 Query: 247 NFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAG 306 +L V + + D + ++ ++ E +D E+V +++ + AG Sbjct: 197 QYLYPIVVQKR-------LNPADDIISDLLKAEVDGE-----MFTDDEVVRTTMLILGAG 244 Query: 307 YETTSSVLSFIMYELA-THPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLR 365 ETTS +L+ Y L +V Q+L E +D + V E LR Sbjct: 245 VETTSHLLANSFYSLLYDDKEVYQELHENLD------------------LVPQAVEEMLR 286 Query: 366 LFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKD 425 ++L+R K+D ++ G+ + +G V++ A + D + + + R + K Sbjct: 287 YRFNLIKLDRTVKEDNDLLGVELKEGENVVVWMSAANLDEEMFEDAFTLNIHRPNNKK-- 344 Query: 426 NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF---SFKPCKETQIPLKLSLGGL 482 + FG+GP C+G A + K+AL L+ F P + + L S G Sbjct: 345 ------HLTFGNGPHFCLGAPLARLEAKIALTTFLKKFKHIEAVPSFQLEDNLTDSATGQ 398 Query: 483 LQPEKPVVLK 492 P+ Sbjct: 399 TLTSLPLKAC 408 >3EL3-A nrPDB Length = 467 Score = 233 bits (594), Expect = 1e-61, Method: Composition-based stats. Identities = 84/444 (18%), Positives = 175/444 (39%), Gaps = 21/444 (4%) Query: 42 TPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSV 101 +P LG+ + F + + +G V G + V A+T+P++ + + Y + Sbjct: 29 GGVPLLGHGWRLARDPLAFMSQL-RDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHI 87 Query: 102 FTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLR 161 K ++ A +R R + P F + PI+ + L + Sbjct: 88 AGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQ 147 Query: 162 REAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFL 221 GK V ++ V + ++ + + R + Sbjct: 148 ----PGKTVDATSESFRVAVRVAARCL--LRGQYMDERAERLCVALATVFRGMYRRMVVP 201 Query: 222 SITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNS 281 ++ +P N + L V + R QK D L ++++++ Sbjct: 202 LGPLYRLPLPANRRFN------DALADLHLLVDEIIAERRASGQKP-DDLLTALLEAKD- 253 Query: 282 KETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN 341 ++ + + E+ Q + + G ET +S + +++ LA HP+ ++++E++AV Sbjct: 254 ---DNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGG 310 Query: 342 KAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYAL 401 P ++ V ++ + V+ E +RL P L R + E+ G IP G ++ YA+ Sbjct: 311 -RPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAI 369 Query: 402 HRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQ 461 RDPK + + +F P+R+ + N+ Y PF +G R C F++ + L + Sbjct: 370 QRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALAT 429 Query: 462 NFSFKPCKETQIPLKLSLGGLLQP 485 + F+ + ++ +G L+P Sbjct: 430 KYRFEQVAGSNDAVR--VGITLRP 451 >4YT3-A nrPDB Length = 410 Score = 232 bits (591), Expect = 3e-61, Method: Composition-based stats. Identities = 83/401 (20%), Positives = 155/401 (38%), Gaps = 69/401 (17%) Query: 69 GKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI--AEDEEW 126 W + + ++D +V + SV T+ G + I I ++ + Sbjct: 41 TDTWNVFKYEDVKRVLSDYKHFSSVRKRTTISVGTDSEE----GSVPEKIQITESDPPDH 96 Query: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186 ++ RSLL+ FT L+ P I + D L+ + + G + + + ++ + Sbjct: 97 RKRRSLLAAAFTPRSLQNWEPRIQEIADELIGQM----DGGTEIDIVASLASPLPIIVMA 152 Query: 187 TSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNIC--VFPRE 244 GV +LL ++D FL PF E ++ V +E Sbjct: 153 DLMGVPSK-------------DRLLFKKWVDTLFL-----PFDREKQEEVDKLKQVAAKE 194 Query: 245 VTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIF 304 +L V + + D + ++ S+ E +D E+V +++ + Sbjct: 195 YYQYLYPIVVQKR-------LNPADDIISDLLKSEVDGE-----MFTDDEVVRTTMLILG 242 Query: 305 AGYETTSSVLSFIMYELA-THPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNET 363 AG ETTS +L+ Y L +V Q+L E +D + V E Sbjct: 243 AGVETTSHLLANSFYSLLYDDKEVYQELHENLD------------------LVPQAVEEM 284 Query: 364 LRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKN 423 LR ++L+R K+D ++ G+ + +G V++ A + D + + +P R + K Sbjct: 285 LRFRFNLIKLDRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFTLNIHRPNNKK 344 Query: 424 KDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS 464 + FG+GP C+G A + K+AL L+ F Sbjct: 345 --------HLTFGNGPHFCLGAPLARLEAKIALTAFLKKFK 377 >5L94-A nrPDB Length = 410 Score = 231 bits (590), Expect = 4e-61, Method: Composition-based stats. Identities = 73/403 (18%), Positives = 152/403 (37%), Gaps = 60/403 (14%) Query: 84 ITDPDMIKTVLVKE-CYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKL 142 + D +K VL ++ +S + +++ + + +R+L++ FT + Sbjct: 49 VFHYDGVKEVLEQKNIFSSDRRPPQNQRQTALGTSLINIDPPKHAEMRALVNKAFTPKAM 108 Query: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDP 202 K P IA+ + L++ + + + + + ++ + GV I+ Sbjct: 109 KAWEPKIARITNELLQEVEHLED----IDIVEHLSYPLPVMVIADILGVPIE-------- 156 Query: 203 FVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLE 262 + D+ D + E+ + + ++ + Sbjct: 157 -----DQRQFKDWSDIIVAGPSNNERETLEKLQQEKMKANDELETYFYRIIEEKR----- 206 Query: 263 DTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELA 322 + D + +++ ++ E K L+D E+V SI+ + AG ETT++++S +Y L Sbjct: 207 --TRPGDDIISVLLQAK-----EEGKQLTDEEIVGFSILLLIAGNETTTNLISNTIYCLM 259 Query: 323 THPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVE 382 ++L+ E E L + E LR L R+ K+DV Sbjct: 260 EDKASFERLKRE------------------KELLPSGIEEVLRYRSPVQALHRIVKEDVT 301 Query: 383 INGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNC 442 + G + G V+ + HRD +Y+ +PE F +R P ++ FG G C Sbjct: 302 LAGKKLKAGEHVVPWMGSAHRDAEYFEDPEVFKIDR---------KPNVHMAFGRGIHFC 352 Query: 443 IGMRFALMNMKLALIRVLQNF---SFKPCKETQIPLKLSLGGL 482 +G A + K+ L ++ + + P E + + GL Sbjct: 353 LGAPLARIEAKIMLAELIDRYPQMDWSPSFELKPIESTFVYGL 395 >5OFQ-A nrPDB Length = 409 Score = 230 bits (587), Expect = 1e-60, Method: Composition-based stats. Identities = 71/395 (17%), Positives = 158/395 (40%), Gaps = 61/395 (15%) Query: 84 ITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLK 143 + D + +K +L S+F+++R + +I + + + +LR+L++ FT ++ Sbjct: 54 VFDYETVKYILKN--PSLFSSKRAMEE---RQESILMMDPPKHTKLRNLVNKAFTPRAIQ 108 Query: 144 EMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPF 203 + I + D L+ + + + + + F ++ + GV I + Sbjct: 109 HLEGHIEEIADYLLDEV----SSKEKFDIVEDFAGPLPIIVIAELLGVPIQD-RALFKKY 163 Query: 204 VENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLED 263 ++ + + F + E FL+ K + R ++ Sbjct: 164 SDDLVSGAENNSDEAFA----------------KMMQKRNEGVIFLQGYFKEIIAERQQN 207 Query: 264 TQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELAT 323 Q+ D + L+++++ E L++ E++ I+ + AG ETT+++++ + + Sbjct: 208 KQE---DLISLLLEAEIDGE-----HLTEEEVLGFCILLLVAGNETTTNLITNGVRYMTE 259 Query: 324 HPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI 383 DVQ +++ +I + +V ETLR +P + R+ +DVE+ Sbjct: 260 DVDVQNEVRRDI------------------SLVPNLVEETLRYYPPIQAIGRIAAEDVEL 301 Query: 384 NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCI 443 I +G V+ + + +RD + P+ F+ R + FG G C+ Sbjct: 302 GECKIKRGQQVISWAASANRDSAKFEWPDTFVVHR---------KTNPHVSFGFGIHFCL 352 Query: 444 GMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS 478 G A M K+A ++L+ F + + S Sbjct: 353 GAPLARMEGKIAFTKLLEKGGFSKVQNQSLKPIDS 387 >3EJB-B nrPDB Length = 404 Score = 230 bits (586), Expect = 1e-60, Method: Composition-based stats. Identities = 82/446 (18%), Positives = 155/446 (34%), Gaps = 72/446 (16%) Query: 52 SYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPV 111 + K F + ++ + P +T + +L + F R P Sbjct: 10 EFLKNPYSFYDTLRAVH-PIYKGSFLKYPGWYVTGYEETAAILKD---ARFKVRTPLPES 65 Query: 112 GFMKSAIS--------IAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRE 163 +S + +RLR+L S FT + P I + L+ ++ + Sbjct: 66 STKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTPRTTESYQPYIIETVHHLLDQVQGK 125 Query: 164 AETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSI 223 + M+VI+ +F + + N E+ ++L + Sbjct: 126 KK---------------MEVISDFAFPLASFVIANIIGVPEEDREQLKEWA--------- 161 Query: 224 TVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKE 283 LI ++ E +++ KE + + + D + +++ + Sbjct: 162 ---ASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREK-- 216 Query: 284 TESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKA 343 L++ E + I+ AG+ETT +++S + L HP+ KL+E D Sbjct: 217 ----DKLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPD------- 265 Query: 344 PPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHR 403 + V E LR RV +D++I G+ I +G V + A +R Sbjct: 266 -----------LIGTAVEECLRYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANR 314 Query: 404 DPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 DP +T P+ F R P + FG G C+G A + ++A+ +LQ Sbjct: 315 DPSIFTNPDVFDITR---------SPNPHLSFGHGHHVCLGSSLARLEAQIAINTLLQRM 365 Query: 464 SFKPCKETQIPLKLSLGGLLQPEKPV 489 + + + G E PV Sbjct: 366 PSLNLADFEWRYRPLFGFRALEELPV 391 >2Y5N-A nrPDB Length = 417 Score = 227 bits (578), Expect = 9e-60, Method: Composition-based stats. Identities = 85/416 (20%), Positives = 161/416 (38%), Gaps = 72/416 (17%) Query: 83 AITDPDMIKTVLVKECYSVFTNRRPFGPV---GFMKSAISIAEDEEWKRLRSLLSPTFTS 139 +T + ++ VL + + P +K + + E RLR L+ FT+ Sbjct: 65 LVTRYEDVRAVLGDGRFVRGPSMTRDEPRTRPEMVKGGLLSMDPPEHSRLRRLVVKAFTA 124 Query: 140 GKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGA-YSMDVITSTSFGVNIDSLNN 198 + + + P + LV + A TG+P L +F + VI GV + Sbjct: 125 RRAESLRPRAREIAHELVDQM---AATGQPADLVAMFARQLPVRVICELL-GVPSADHD- 179 Query: 199 PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKE 258 RF FLS V E+ ++ M + Sbjct: 180 -------------RFTRWSGAFLS--------------TAEVTAEEMQEAAEQAYAYMGD 212 Query: 259 SRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIM 318 ++ D + ++ +++ +++ LS+ EL+ +I + AGYE+T++ ++ + Sbjct: 213 LIDRRRKEPTDDLVSALVQARDQQDS-----LSEQELLDLAIGLLVAGYESTTTQIADFV 267 Query: 319 YELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP--IAMRLERV 376 Y L T P+++++L + + E + V E R P + R Sbjct: 268 YLLMTRPELRRQL------------------LDRPELIPSAVEELTRWVPLGVGTAFPRY 309 Query: 377 CKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFG 436 +DV + G+ I G V+ + A +RD + + ++ +R P + FG Sbjct: 310 AVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDR---------TPNQHLGFG 360 Query: 437 SGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQP--EKPVV 490 G +C+G A + +++AL +LQ + L+ S G LL+ E PVV Sbjct: 361 HGVHHCLGAPLARVELQVALEVLLQRLPGIRLGIPETQLRWSEGMLLRGPLELPVV 416 >4GGV-A nrPDB Length = 418 Score = 224 bits (571), Expect = 6e-59, Method: Composition-based stats. Identities = 84/405 (20%), Positives = 146/405 (36%), Gaps = 61/405 (15%) Query: 71 VWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLR 130 VW Y + + + D D + ++ +S + ++ R Sbjct: 55 VWNVYGYPEAMDILNDHDTF-------TSDLAHLLPVSVDAPLLEGDMSQMDPPRHRKYR 107 Query: 131 SLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVI-TSTSF 189 L+S FT + +M +A L+ + + E L AY + VI + Sbjct: 108 QLVSRAFTPRLVADMETRVADITRELLDAVDGKPEIEIAADL-----AYPLPVIVIAELL 162 Query: 190 GVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFL 249 GV + L + D + F FL + R+ T L Sbjct: 163 GVP-------------AGDRDLFKKWADDIIEGFSGFSFLDTSGQG---EQDVRDATERL 206 Query: 250 RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYET 309 R + M E + R D L ++ ++ E L+D E+V + I + G+ T Sbjct: 207 RPLLDYMAGHVTERRRTPREDLLTHLVQAEVDGE-----RLTDNEIVNVANILLVTGHIT 261 Query: 310 TSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPI 369 T+ L + L P+V K++ + + + E LR+ Sbjct: 262 TTMTLGNTVLCLDADPEVAAKVRADR------------------SLVPGAIEEALRVLSP 303 Query: 370 AMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP 429 + L R ++VE+ G IPK +VM+ A +RDP+ +T+PE + P R DP Sbjct: 304 SAALARGTSREVEVAGTVIPKDQIVMLWLGAGNRDPRQFTDPEVYDPTR---------DP 354 Query: 430 YIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474 + FG G C+G A + ++AL + F + P Sbjct: 355 NPHFGFGRGIHFCLGAPLARLEGRVALNALFDRFPVLRTDPAKPP 399 >4Z5P-A nrPDB Length = 400 Score = 223 bits (568), Expect = 1e-58, Method: Composition-based stats. Identities = 80/417 (19%), Positives = 157/417 (37%), Gaps = 70/417 (16%) Query: 83 AITDPDMIKTVLVKECYSV---FTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTS 139 +T D ++ +S + P+ I + E RLR LLS FT+ Sbjct: 48 MVTRYDDVRAANSDPRFSRAQIGEDTPRTTPLARRSDTILSLDPPEHTRLRRLLSKAFTA 107 Query: 140 GKLKEMVPIIAQYGDVLVRNLRREAETGKPVTL-KDVFGAYSMDVITSTSFGVNIDSLNN 198 ++ M + + L+ + R G P + +D+ +++ VI GV Sbjct: 108 RRMGAMQSWLEELFAGLLDGVERT---GHPADIVRDLAQPFTIAVICRLL-GVPY----- 158 Query: 199 PQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKE 258 + RF +S T + + + + +L V + Sbjct: 159 ---------EDRGRFQHWSEVIMSTTAYSKEEAVSADAS-------IRAYLADLVSARRA 202 Query: 259 SRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIM 318 + D L +++ ++ + L++ EL+ + + AG+ET++ L ++ Sbjct: 203 A-------PHDDLLGVLVSAR-----DDDDRLTEDELITFGVTLLVAGHETSAHQLGNMV 250 Query: 319 YELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRL--ERV 376 Y L TH D L+E Q E L V E LR P+ + R+ Sbjct: 251 YALLTHEDQLSLLRE------------------QPELLPRAVEELLRFVPLGNGVGNARI 292 Query: 377 CKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFG 436 +DVE++G + G V+ + +RDP+ + +P++ R + + FG Sbjct: 293 ALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLDITR---------EKNPHLAFG 343 Query: 437 SGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKV 493 G C+G + A M +++A+ +L+ F ++ GGL + + + + Sbjct: 344 HGAHYCLGAQLARMELRVAIGGLLERFPGLRLAVPADQVEWKTGGLFRGPQRLPIAW 400 >4JBT-A nrPDB Length = 410 Score = 220 bits (560), Expect = 1e-57, Method: Composition-based stats. Identities = 82/398 (20%), Positives = 145/398 (36%), Gaps = 67/398 (16%) Query: 83 AITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI--AEDEEWKRLRSLLSPTFTSG 140 +TD ++K + + T R + +G + S+ + E +RLR + T Sbjct: 54 LLTDTRLVKDINAWSLWQSGTVTRQWPLIGMIDVDRSMFTVDGPEHRRLRIKTTQALTRR 113 Query: 141 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ 200 +L + P I +Y L+ +L R G V LK VF + S GV + Sbjct: 114 RLDALKPTIERYVAELLDDLERAGADGAVVDLKSVFAYPLPMRVISALMGVPSEDQEQLL 173 Query: 201 DPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESR 260 + F L P E L + E+ + + V+R Sbjct: 174 TWYK-------------------AFFSILTPQDERLRV---IDEMHGYFTEMVRR----- 206 Query: 261 LEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYE 320 T + D +I + T+ L++ E++ + AG+ETT S++ + Sbjct: 207 --KTAEPGDDLTSALIYA-----TDGETPLTEEEVIGNLQALVAAGHETTVSLILTAVRA 259 Query: 321 LATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF-PIAMRLERVCKK 379 L +HP+ + ++ D + + + ETLR P+ L R + Sbjct: 260 LLSHPEQLRLVR---DGEIG---------------WETAIEETLRWDGPVIHLLMRFATE 301 Query: 380 DVEINGMFIPKGVVVMIPSYALHRDPKYW-TEPEKFLPERFSKKNKDNIDPYIYTPFGSG 438 D+++ IP+G V++ A+ RD + + F R + + FG G Sbjct: 302 DIDLGDAVIPRGEGVVMSYRAIGRDITVHGADADDFDITRATAAR--------HISFGHG 353 Query: 439 PRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLK 476 P C G A + +AL + F P +PL Sbjct: 354 PHICPGAALARLEAAIALPALFTRF---PHLHPALPLD 388 >4YZR-A nrPDB Length = 405 Score = 219 bits (558), Expect = 2e-57, Method: Composition-based stats. Identities = 77/456 (16%), Positives = 150/456 (32%), Gaps = 80/456 (17%) Query: 44 LPFLGNILSYHKGFCMFDMECH----------KKYG---KVWGFYDGQQPVLAITDPDMI 90 L F + +H K++G W + + D + Sbjct: 4 LMFHPHGKEFHHNPFSVLGRFREEEPIHRFELKRFGATYPAWLITRYDDCMAFLKDNRIT 63 Query: 91 KTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIA 150 + V + F+ + + + RLRSL+ FT ++ + I Sbjct: 64 RDVKNVMNQEQIKMLNVSEDIDFVSDHMLAKDTPDHTRLRSLVHQAFTPRTIENLRGSIE 123 Query: 151 QYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKL 210 Q + L+ + +E + D++ S + + ++ E+ + Sbjct: 124 QIAEQLLDEMEKENKA---------------DIMKSFASPLPFIVISELMGIPKEDRSQF 168 Query: 211 LRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQ-KHRV 269 + +++ RE+TN + K + D + K + Sbjct: 169 QIWTN------------------AMVDTSEGNRELTNQALREFKDYIAKLIHDRRIKPKD 210 Query: 270 DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQ 329 D + ++ ++ E+ LS+ EL + + + AG ETT ++L L H + Sbjct: 211 DLISKLVHAE-----ENGSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECE 265 Query: 330 KLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF-PIAMRLERVCKKDVEINGMFI 388 KL++ Q E + V E LR P+ M R +D G I Sbjct: 266 KLKQ------------------QPEMIATAVEELLRYTSPVVMMANRWAIEDFTYKGHSI 307 Query: 389 PKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFA 448 +G ++ I + +RDP ++ PE R P + FG G C+G A Sbjct: 308 KRGDMIFIGIGSANRDPNFFENPEILNINR---------SPNRHISFGFGIHFCLGAPLA 358 Query: 449 LMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQ 484 + +A +L+ F ++ L+ Sbjct: 359 RLEGHIAFKALLKRFPDIELAVAPDDIQWRKNVFLR 394 >5CJE-A nrPDB Length = 393 Score = 218 bits (554), Expect = 7e-57, Method: Composition-based stats. Identities = 86/462 (18%), Positives = 158/462 (34%), Gaps = 84/462 (18%) Query: 47 LGNILSYHKGFCMFDMECHKKY------GKVWGFYDGQQPVL---AITDPDMIKTVLVKE 97 +GN++ + F + + Y G V + + + L Sbjct: 1 MGNVIDLGEYGARFTEDPYPVYAELRERGPVHWVRTPPPEAFEGWLVVGHEEARAALADP 60 Query: 98 CYSVFTNRRPFGP--VGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDV 155 S ++ V M + + + E RLRSL++ FT +++ + P I + D Sbjct: 61 RLSKDGTKKGLTSLDVELMGPYLLVVDPPEHTRLRSLVARAFTMRRVEALRPRIQEITDG 120 Query: 156 LVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDF 215 L+ + G+ + + VI + + F + +++ Sbjct: 121 LLDEM---LPRGRADLVDSFAYPLPITVICELL-----GVPDIDRVTFRALSNEIVAPTG 172 Query: 216 LDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLM 275 D + +L + + + + D L + Sbjct: 173 GDA-------------------ELAAYERLAAYLDELIDDKRSTA------PADDLLGDL 207 Query: 276 IDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI 335 I ++ E LS EL A + I + AG+ETT ++++ ++ L THPD L+ + Sbjct: 208 IRTR----AEDDDRLSGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAALRAD- 262 Query: 336 DAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF-PIAMRLERVCKKDVEINGMFIPKGVVV 394 M LD V E LR P+ R + +EI G I +G V Sbjct: 263 -----------------MTLLDGAVEEVLRFEGPVETATYRYAAESMEIGGTAIAEGDPV 305 Query: 395 MIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKL 454 MI A RDP +P F R P + FG G C+G A + ++ Sbjct: 306 MIGLDAAGRDPARHPDPHVFDIHRA---------PQGHLAFGHGIHYCLGAPLARLEARV 356 Query: 455 ALIRVLQN---FSFKPCKETQIPLKLSLGGLLQPEKPVVLKV 493 AL +L+ + + P G L++ + + ++ Sbjct: 357 ALRSLLERCPDLALDGPPGARPP-----GMLIRGVRRLPVRW 393 >4OQS-A nrPDB Length = 433 Score = 217 bits (552), Expect = 9e-57, Method: Composition-based stats. Identities = 84/395 (21%), Positives = 130/395 (32%), Gaps = 74/395 (18%) Query: 72 WGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRS 131 W + DP K R + E R R Sbjct: 48 WLVTSHAAARTVMIDPRFSNRPEHKHPVFSVIPRPGGATKAPAPGWFINMDAPEHTRYRR 107 Query: 132 LLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGV 191 +L FT ++KE+ P I Q + +L A+ G PV L F ++ GV Sbjct: 108 MLISQFTVRRIKELEPRIVQITE---DHLDAMAKAGPPVDLVQAFALPVPSLVICELLGV 164 Query: 192 NIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRK 251 + FF T + ++ EVT L K Sbjct: 165 SY---------------------ADHAFFQEQTTI--------MASVDKTQDEVTTALGK 195 Query: 252 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTS 311 + + E + D L +I + L+D EL +++ + AG+ETT+ Sbjct: 196 LTRYIAELVATKRLSPKDDLLGSLITDTD---------LTDEELTNIALLLLVAGHETTA 246 Query: 312 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAM 371 ++L + L HP+ L V E LR I Sbjct: 247 NMLGLGTFALLQHPEQIAALDS-----------------------PDAVEELLRYLSIVH 283 Query: 372 RLE--RVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP 429 R +DVE+ G I KG V I A++RDPK + EP+ +R +D Sbjct: 284 LGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDR--------VDA 335 Query: 430 YIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS 464 + FG G C+G + A + M++ R+ F Sbjct: 336 RKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFP 370 >1GWI-A nrPDB Length = 411 Score = 217 bits (552), Expect = 1e-56, Method: Composition-based stats. Identities = 82/413 (19%), Positives = 142/413 (34%), Gaps = 67/413 (16%) Query: 70 KVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI--AEDEEWK 127 VW + +TDP ++K + V + + +G S+ + E + Sbjct: 42 PVWAVTHHAEAKALLTDPRLVKDINVWGAWRRGEIPADWPLIGLANPGRSMLTVDGAEHR 101 Query: 128 RLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITST 187 RLR+L++ T +++ M I + D L+ L + G V LK F + + Sbjct: 102 RLRTLVAQALTVRRVEHMRGRITELTDRLLDELPAD---GGVVDLKAAFAYPLPMYVVAD 158 Query: 188 SFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTN 247 G +E + + FF + T P EV Sbjct: 159 LMG-------------IEEARLPRLKVLFEKFFSTQTP----------------PEEVVA 189 Query: 248 FLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGY 307 L + M ++ D +I + +E+ L+D E+V+ + + AG+ Sbjct: 190 TLTELASIMTDTVAAKRAAPGDDLTSALIQA-----SENGDHLTDAEIVSTLQLMVAAGH 244 Query: 308 ETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF 367 ETT S++ + L+THP+ + + VV ETLR Sbjct: 245 ETTISLIVNAVVNLSTHPEQRALVLSGEAE------------------WSAVVEETLRFS 286 Query: 368 PI-AMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYW-TEPEKFLPERFSKKNKD 425 + L R +DV + IP G +++ AL RD + ++F R Sbjct: 287 TPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTADRFDLTR------- 339 Query: 426 NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS 478 + FG GP C G + M +AL + F L+ Sbjct: 340 -TSGNRHISFGHGPHVCPGAALSRMEAGVALPALYARFPHLDLAVPAAELRNK 391 >1Z8P-A nrPDB Length = 404 Score = 215 bits (548), Expect = 3e-56, Method: Composition-based stats. Identities = 87/447 (19%), Positives = 152/447 (34%), Gaps = 78/447 (17%) Query: 52 SYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVK-----ECYSVFTNRR 106 S+H + E + V Q +T D K L + + Sbjct: 11 SFHVDWYRTYAELRET-APVTPVRFLGQDAWLVTGYDEAKAALSDLRLSSDPKKKYPGVE 69 Query: 107 PFGP--VGFMKSAIS-------IAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLV 157 P +GF + + ++ RLR L+S FT +++ M P + Q L+ Sbjct: 70 VEFPAYLGFPEDVRNYFATNMGTSDPPTHTRLRKLVSQEFTVRRVEAMRPRVEQITAELL 129 Query: 158 RNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLD 217 + ++G + + VI + K F Sbjct: 130 DEV---GDSGVVDIVDRFAHPLPIKVICELL---------------GVDEKYRGEFGRWS 171 Query: 218 PFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMID 277 L + REV NF+ V+R + + D L +I Sbjct: 172 SEILVMDP-------ERAEQRGQAAREVVNFILDLVERRR-------TEPGDDLLSALIR 217 Query: 278 SQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDA 337 Q+ + LS EL + +++ + AG+E++ S++ Y L THPD ++ + A Sbjct: 218 VQD----DDDGRLSADELTSIALVLLLAGFESSVSLIGIGTYLLLTHPDQLALVRRDPSA 273 Query: 338 VLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIP 397 L V E LR R ++VEI G+ IP+ V++ Sbjct: 274 ------------------LPNAVEEILRYIAPPETTTRFAAEEVEIGGVAIPQYSTVLVA 315 Query: 398 SYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALI 457 + A +RDPK + +P +F R ++ + FG G C+G A + ++AL Sbjct: 316 NGAANRDPKQFPDPHRFDVTRDTRG---------HLSFGQGIHFCMGRPLAKLEGEVALR 366 Query: 458 RVLQNFSFKPCKETQIPLKLSLGGLLQ 484 + F + LL+ Sbjct: 367 ALFGRFPALSLGIDADDVVWRRSLLLR 393 >2VZM-A nrPDB Length = 436 Score = 215 bits (548), Expect = 3e-56, Method: Composition-based stats. Identities = 80/458 (17%), Positives = 157/458 (34%), Gaps = 72/458 (15%) Query: 47 LGNILS-YHKGFCMFDMECHKKYGKVWGFYD--GQQPVLAITDPDMIKTVLVKECYSVF- 102 LG + + + G G + L + D + VL +S Sbjct: 37 LGALGQDFAADPYPTYARLRAE-GPAHRVRTPEGNEVWLVV-GYDRARAVLADPRFSKDW 94 Query: 103 --TNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL 160 + + + ++ RLR L++ FT +++ + P + + D LV + Sbjct: 95 RNSTTPLTEAEAALNHNMLESDPPRHTRLRKLVAREFTMRRVELLRPRVQEIVDGLVDAM 154 Query: 161 RREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFF 220 A G+ ++ + + VI+ V + + D F Sbjct: 155 LA-APDGRADLMESLAWPLPITVISELL--------------GVPEPDRAAFRVWTDAFV 199 Query: 221 LSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQN 280 E++ +L + + + + D L ++ + + Sbjct: 200 FPDDP----------AQAQTAMAEMSGYLSRLIDSKR-------GQDGEDLLSALVRTSD 242 Query: 281 SKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLP 340 E L+ EL+ + I + AG+ETT ++++ MY L +HPD L+ + Sbjct: 243 ----EDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRAD------ 292 Query: 341 NKAPPTYDTVLQMEYLDMVVNETLRLF-PIAMRLERVCKKDVEINGMFIPKGVVVMIPSY 399 M LD V E LR P+ R + V+++G IP G V++ Sbjct: 293 ------------MTLLDGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLA 340 Query: 400 ALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRV 459 HR P+ + +P +F R D + FG G CIG A + ++A+ + Sbjct: 341 DAHRTPERFPDPHRFDIRR---------DTAGHLAFGHGIHFCIGAPLARLEARIAVRAL 391 Query: 460 LQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRD 497 L+ + L +++ K + ++ Sbjct: 392 LERCPDLALDVSPGELVWYPNPMIRGLKALPIRWRRGR 429 >4OQR-A nrPDB Length = 457 Score = 214 bits (546), Expect = 5e-56, Method: Composition-based stats. Identities = 84/395 (21%), Positives = 132/395 (33%), Gaps = 74/395 (18%) Query: 72 WGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRS 131 W + DP K R + + E R R Sbjct: 87 WLVTSHAAARTVMIDPRFSNRPEHKHPVFSVIPRPGGATKAPAPGWFTNMDAPEHTRYRR 146 Query: 132 LLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGV 191 +L FT ++KE+ P I + + +L A+ G PV L F ++ GV Sbjct: 147 MLISQFTVRRIKELEPRIVRITE---DHLDAMAKAGPPVDLVQAFALPVPSLVICELLGV 203 Query: 192 NIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRK 251 + FF T ++++ EVT L K Sbjct: 204 SY---------------------ADHAFFQEQTTI--------MVSVDKTQDEVTTALGK 234 Query: 252 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTS 311 + + E + D L +I + L+D EL ++I + AG+ETT+ Sbjct: 235 LTRYIAELVATKRLSPKDDLLGSLITDTD---------LTDEELTNIALILLVAGHETTA 285 Query: 312 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAM 371 ++L + L HP+ L V E LR I Sbjct: 286 NMLGLGTFALLQHPEQIANLDS-----------------------PDAVEELLRYLSIVH 322 Query: 372 RLE--RVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP 429 R +DVE+ G I KG V I A++RDPK + EP+ +R +D Sbjct: 323 LGTPNRAALEDVELEGQMIRKGDTVAIGLPAVNRDPKVFDEPDILQLDR--------VDA 374 Query: 430 YIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS 464 + FG G C+G + A + M++ R+ F Sbjct: 375 RKHAAFGGGIHQCLGQQLARVEMRIGFTRLFARFP 409 >5XW2-A nrPDB Length = 419 Score = 213 bits (541), Expect = 2e-55, Method: Composition-based stats. Identities = 71/404 (17%), Positives = 148/404 (36%), Gaps = 61/404 (15%) Query: 72 WGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPV-GFMKSAISIAEDEEWKRLR 130 W Y + + + DP S + P G F + + + + + LR Sbjct: 55 WNVYGYAEAIEVLGDPGTFS--------SHMSRLLPMGADEAFTEGDLLQTDPPDHRELR 106 Query: 131 SLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFG 190 L+S FT + E+ P I L+ V + D++T+ ++ Sbjct: 107 KLVSHAFTPKVVAELEPRITALTQELLD---------------AVADRDTFDLMTALAYP 151 Query: 191 VNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLR 250 + + + + + + L ++ S+ + I +R Sbjct: 152 LPVTVVAELLS--IPSADRHLFEGWMTEIVHSLGDVSMEDAPEDQERIFEA---GMAPMR 206 Query: 251 KSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETT 310 K ++ ++E E ++ R D + +I+++ + L+D +V + + + AGY TT Sbjct: 207 KMLEYLREHAAECRRRPRGDLMGKLIEAEV-----DGRRLTDNHIVNFAKMLLIAGYLTT 261 Query: 311 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA 370 + ++ + L ++P+ +++ + + ++ E++R Sbjct: 262 TMLIGNTVLCLDSYPEQAARVRADR------------------SLIPGLLEESMRFLSPV 303 Query: 371 MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 430 R +DVE+ G + +VM+ A +RD + + EPE F R P Sbjct: 304 AATYRATTRDVEVAGQRLSADQMVMVWFGAANRDARQFAEPELFDMTR---------GPN 354 Query: 431 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474 + FG G C+G A M ++AL +L F + P Sbjct: 355 PHLGFGRGIHFCLGGPLARMEGRVALDHLLDRFPELYTDPERPP 398 >4UBS-A nrPDB Length = 393 Score = 212 bits (540), Expect = 3e-55, Method: Composition-based stats. Identities = 76/423 (17%), Positives = 146/423 (34%), Gaps = 72/423 (17%) Query: 78 QQPVLAITDPDMIKTVLVKECYSVFTNRRPFGP-------VGFMKSAISIAEDEEWKRLR 130 + V +T + +L + S F V + A+ +D E + R Sbjct: 36 GRSVWVVTGHAAARALLSDQRLSSDRTLPRFPATTERFEAVRTRRVALLGVDDPEHRTQR 95 Query: 131 SLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFG 190 +L P+FT + + P I + D L+ + + G P L F ++ G Sbjct: 96 RMLVPSFTLKRAAALRPRIQETVDGLLDAMEAQ---GPPAELVSAFALPLPSMVICALLG 152 Query: 191 VNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLR 250 V F E+ + L+ + + ++ ++L Sbjct: 153 VPY-----ADHDFFESQSR------------------RLLRGPGIAEVQDARAQLDDYLY 189 Query: 251 KSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETT 310 + R + ++ L +I E + + ELV+ + + + AG+ETT Sbjct: 190 ALIDRKR-------KEPGDGLLDDLIQ-----EQLNRGTVDRAELVSLATLLLIAGHETT 237 Query: 311 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA 370 ++++S + L HP+ +L+ E + V E LR IA Sbjct: 238 ANMISLGTFTLLRHPEQLAELRAE------------------PGLMPAAVEELLRFLSIA 279 Query: 371 MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 430 L RV +D+E+ G I V+ + ++RD + EP+ R ++ Sbjct: 280 DGLLRVATEDIEVAGTTIRADEGVVFATSVINRDAAGFAEPDALDWHRSARH-------- 331 Query: 431 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVV 490 + FG G C+G A M++AL + + + G +Q + Sbjct: 332 -HVAFGFGIHQCLGQNLARAEMEIALGTLFERLPGLRLAAPADEIPFKPGDTIQGMLELP 390 Query: 491 LKV 493 + Sbjct: 391 VTW 393 >6A7J-A nrPDB Length = 411 Score = 210 bits (534), Expect = 1e-54, Method: Composition-based stats. Identities = 81/413 (19%), Positives = 153/413 (37%), Gaps = 68/413 (16%) Query: 71 VWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI--AEDEEWKR 128 V+ ++ +TD ++K + V + + +G + S+ + + +R Sbjct: 39 VYAVTHHKEARALLTDSRVVKDINVWNAWQRGEIPADWPLIGLVNPGRSMLTVDGPDHRR 98 Query: 129 LRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFG-AYSMDVITST 187 LR+L++ T +++++ I + + L G+PV LK F M+VI S Sbjct: 99 LRTLVAQALTVKRVEKLRAGIEALTNASLERL-AALPAGEPVDLKAEFAYPLPMNVI-SE 156 Query: 188 SFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTN 247 GV+ ++ F + F + ++ Sbjct: 157 LMGVDAADHPRLKELFEK----------------------FFSTQTPPEEVPQMMADLGT 194 Query: 248 FLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGY 307 K V+ K + D +I + +E L+D E++ + I AG+ Sbjct: 195 LFTKIVEEKKAN-------PGDDLTSALIAA-----SEDGDHLTDEEILNTLQLIIAAGH 242 Query: 308 ETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL- 366 ETT S++ ++ LA HP+ ++K+ L + P + V+ ETLR Sbjct: 243 ETTISLIVNVVEALAIHPEQRKKV-------LSGEIP-----------WEGVIEETLRWN 284 Query: 367 FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYW-TEPEKFLPERFSKKNKD 425 P + L R +D+E+ +PKG +++ AL RD + + F R Sbjct: 285 TPTSHVLIRFATEDIEVGDKVLPKGEGLVVSFGALGRDEEQYGPTAGDFDATR------- 337 Query: 426 NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS 478 P + FG GP C G + + +AL + + F L+ Sbjct: 338 --TPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVPAAELRNK 388 >3N9Z-A nrPDB Length = 487 Score = 208 bits (529), Expect = 5e-54, Method: Composition-based stats. Identities = 102/483 (21%), Positives = 192/483 (39%), Gaps = 37/483 (7%) Query: 27 THSHGLFKKLGIPGPTPLPFLGNILSYHK-----GFCMFDMECHKKYGKVWGFYDGQQPV 81 T S F ++ PG N+ + + + ++ +KYG ++ G Sbjct: 2 TRSPRPFNEIPSPGDNGWL---NLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVES 58 Query: 82 LAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKS-----AISIAEDEEWKRLR-----S 131 + + DP+ + + E + P V + + + + + WK+ R Sbjct: 59 VYVIDPEDVALLFKSEGPNPERFLIP-PWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQE 117 Query: 132 LLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGV 191 +++P T L + + + VL R +++ + D ++ + IT+ FG Sbjct: 118 VMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGE 177 Query: 192 NIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNF--- 248 L +P + + F S+ + + + + V + Sbjct: 178 RQGMLEEVVNPEAQRFIDAIY----QMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVI 233 Query: 249 LRKSVKRMKESRLEDTQKHRV--DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAG 306 K+ + E QK V D+ ++ +S ++ A + G Sbjct: 234 FSKADIYTQNFYWELRQKGSVHHDYRGILYR------LLGDSKMSFEDIKANVTEMLAGG 287 Query: 307 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 366 +TTS L + +YE+A + VQ L+ E+ A + + L + ETLRL Sbjct: 288 VDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRL 347 Query: 367 FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426 PI++ L+R D+ + IP +V + YAL R+P ++ +PE F P R+ K+K N Sbjct: 348 HPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDK-N 406 Query: 427 IDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPE 486 I + FG G R C+G R A + M + LI +L+NF + + + + +L PE Sbjct: 407 ITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVG--TTFNLILMPE 464 Query: 487 KPV 489 KP+ Sbjct: 465 KPI 467 >3MZS-A nrPDB Length = 486 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 104/478 (21%), Positives = 193/478 (40%), Gaps = 36/478 (7%) Query: 38 IPGPTPLPFLGNILSYHKG-----FCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKT 92 IP P +L N+ + + +E +KYG ++ G + I P+ + Sbjct: 13 IPSPGDNGWL-NLYHFWREKGSQRIHFRHIENFQKYGPIYREKLGNLESVYIIHPEDVAH 71 Query: 93 VLVKECYSVFTNRRPFGPVGFM------KSAISIAEDEEWKRLRSLLSPTFT-SGKLKEM 145 + E + R P + + WK+ R +L+ +K Sbjct: 72 LFKFEGS--YPERYDIPPWLAYHRYYQKPIGVLFKKSGTWKKDRVVLNTEVMAPEAIKNF 129 Query: 146 VPIIAQYGDVLVRNLRR---EAETGKPV-TLKDVFGAYSMDVITSTSFGVNIDSLNNPQD 201 +P++ V L + + +GK V +K+ ++ + IT+ FG + L + Sbjct: 130 IPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIKEDLFHFAFESITNVMFGERLGMLEETVN 189 Query: 202 PFVENTKKLLRFDFLDPFFLSITVFPFLIPILEV---LNICVFPREVTNFLRKSVK-RMK 257 P + + + + V P L + + + N K + + Sbjct: 190 PEAQKFIDAV-YKMFHTSVPLLNVPPELYRLFRTKTWRDHVAAWDTIFNKAEKYTEIFYQ 248 Query: 258 ESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFI 317 + R + ++ L ++ S+ + ++ A + G TTS L + Sbjct: 249 DLRRKTEFRNYPGILYCLLKSE---------KMLLEDVKANITEMLAGGVNTTSMTLQWH 299 Query: 318 MYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVC 377 +YE+A +VQ+ L+EE+ + + L + ETLRL PI++ L+R Sbjct: 300 LYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKASIKETLRLHPISVTLQRYP 359 Query: 378 KKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGS 437 + D+ + IP +V + YA+ RDP +++ P+KF P R+ K+KD I + FG Sbjct: 360 ESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRWLSKDKDLIH-FRNLGFGW 418 Query: 438 GPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVES 495 G R C+G R A + M L LI +L+NF + + +L +L P+KP+ L Sbjct: 419 GVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNL--ILTPDKPIFLVFRP 474 >5IT1-A nrPDB Length = 399 Score = 207 bits (526), Expect = 1e-53, Method: Composition-based stats. Identities = 77/416 (18%), Positives = 142/416 (34%), Gaps = 71/416 (17%) Query: 73 GFYDGQQPVLAITDPDMIKTVLVKECYSVFT-----NRRPFGPVGFMKSAISIAEDEEWK 127 F G + L T + ++ VL +SV + + ++ + E Sbjct: 38 TFTSGHEAWLV-TGYEQVRAVLRDPSFSVGVPHALHTQDGVVTQKPGRGSLLWQDAPEHT 96 Query: 128 RLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITST 187 R LL+ FT +++ + P I + D +L G PV L F ++ S Sbjct: 97 DDRKLLAKEFTVRRMQALRPNIQRIVD---EHLDAIEARGGPVDLVKTFANPVPSMVISD 153 Query: 188 SFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTN 247 FGV + F E + ++R D + + Sbjct: 154 LFGVPA----ERRAEFQEIAEAMMRVD------------------QDAAATEAAGMRLGG 191 Query: 248 FLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGY 307 L + V+ + + D + +I ++ + + D+ L+ + + A + Sbjct: 192 LLYQLVQERRAN-------PGDDLISALITTE-----DPDGVIDDMFLMNAAGTLLIAAH 239 Query: 308 ETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF 367 +TT+ ++ L PD LQ++ + V E LR Sbjct: 240 DTTACMIGLGTALLLDRPDQLALLQKD------------------PSLIGNAVEELLRYL 281 Query: 368 PIAM-RLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426 I ERV +D EI G+ I KG V+ + DP + +PE+F R Sbjct: 282 TIGQFGAERVATQDGEIGGVRIAKGEQVVTHLLSADFDPAFVEDPERFDITR-------- 333 Query: 427 IDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGL 482 P + FG G CIG + A + +++ + + F + L+ + Sbjct: 334 -RPAPHLAFGFGAHQCIGQQLARIELQIVFGTLFRRFPTLRLAKPVEELRFRNDMV 388 >4XE3-A nrPDB Length = 407 Score = 206 bits (525), Expect = 1e-53, Method: Composition-based stats. Identities = 81/470 (17%), Positives = 165/470 (35%), Gaps = 85/470 (18%) Query: 40 GPTP------LPF-LGNILSYHKGFCMFDMECHKKYGKVWGFYD--GQQPVLAITDPDMI 90 GPTP PF L + L ++ + V G+ +T Sbjct: 7 GPTPADAVPAYPFSLPHALDL--DPHYAELRRDE---PVSRVRLPYGEGTAWLVTRMSDA 61 Query: 91 KTVLVKECYSVFTNRRPFGPVGF----MKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMV 146 + VL +S P P F + + + RLR L+ FT+ +++EM Sbjct: 62 RIVLGDSRFSTAAATDPATPRMFPTPPEPDGVLAQDPPDHTRLRRLVGKAFTARRVEEMR 121 Query: 147 PIIAQYGDVLVRNLRREAETGKPVTLKDVFG-AYSMDVITSTSFGVNIDSLNNPQDPFVE 205 P + D L+ ++ G P L + + + VI GV ++ + Sbjct: 122 PRVRSLVDSLLDDM---VAHGSPADLVEFLAVPFPVAVICELL-GVPLEDRD-------- 169 Query: 206 NTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQ 265 F + + L I ++ ++ V + +++ E Sbjct: 170 -------------LFRTFSDAMLSSTRLTAAEIQRVQQDFMVYMDGLVAQRRDAPTE--- 213 Query: 266 KHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHP 325 D L + + T++ L+ E+V + + AG+ET+ + ++ +++ L T Sbjct: 214 ----DLLGALALA-----TDNDDHLTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLTER 264 Query: 326 DVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMR--LERVCKKDVEI 383 + L + + V E LR P+ RV +DVE+ Sbjct: 265 KRYESLVAD------------------PALVPAAVEEMLRYTPLVSAGSFVRVATEDVEL 306 Query: 384 NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCI 443 + + + G ++ + +RD + + ++ R + + FG G +CI Sbjct: 307 STVTVRAGEPCVVHFASANRDEEVFDHADELDFHR---------ERNPHIAFGHGAHHCI 357 Query: 444 GMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKV 493 G + + ++ AL +++ F E LK G L++ + ++ Sbjct: 358 GAQLGRLELQEALSALVRRFPTLDLAEPVAGLKWKQGMLIRGLERQIVSW 407 >6A7I-A nrPDB Length = 411 Score = 205 bits (522), Expect = 3e-53, Method: Composition-based stats. Identities = 81/413 (19%), Positives = 150/413 (36%), Gaps = 68/413 (16%) Query: 71 VWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI--AEDEEWKR 128 V+ + +TD ++K + V + + +G S+ + + +R Sbjct: 39 VYAVTRHAEARALLTDSRVVKDIDVWNAWRRGEIPMDWPLIGLANPGRSMLTVDGADHRR 98 Query: 129 LRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFG-AYSMDVITST 187 LR+L++ T +++ + I + + L G+PV LK F M+VI S Sbjct: 99 LRTLVAQALTVKRVERLRAGIEALTNASLEKL-AALPAGEPVDLKAEFAYPLPMNVI-SE 156 Query: 188 SFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTN 247 GV+ ++ F + F + ++ Sbjct: 157 LMGVDAADHPRLKELFEK----------------------FFSTQTPPEEVPQMMADLGA 194 Query: 248 FLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGY 307 K V + D +I + +E+ L+D E+V + I AG+ Sbjct: 195 LFTKIVDAKR-------TNPGDDLTSALIAA-----SENGDHLTDEEIVNTLQLIIAAGH 242 Query: 308 ETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL- 366 ETT S++ ++ L THP+ ++K+ ++ + D V+ ETLR Sbjct: 243 ETTISLIVNVVEALQTHPEQRKKV---LNGEIG---------------WDGVIEETLRWN 284 Query: 367 FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYW-TEPEKFLPERFSKKNKD 425 P + L R +D+E+ +PKG ++I AL RD + + +F R Sbjct: 285 TPTSHVLIRFATEDIEVGDKILPKGEGLIISFGALGRDEEQYGPTAGEFDATR------- 337 Query: 426 NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS 478 P + FG GP C G + + +AL + + F L+ Sbjct: 338 --TPNRHIAFGHGPHVCPGAALSRLEAGIALPALYERFPELDLAVPASDLRNK 388 >2WIO-A nrPDB Length = 431 Score = 204 bits (520), Expect = 5e-53, Method: Composition-based stats. Identities = 79/435 (18%), Positives = 135/435 (31%), Gaps = 70/435 (16%) Query: 64 CHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAED 123 +YG VW + + D + + V P I + Sbjct: 64 WQDRYG-VWHVFRHADVQTVLRDTATFSS----DPTRVIEGASP------TPGMIHEIDP 112 Query: 124 EEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDV 183 E + LR ++S FT + ++ P I L+ A+ G+ L DV Sbjct: 113 PEHRALRKVVSSAFTPRTISDLEPRIRDVTRSLL------ADAGESFDLVDVLAFPLPVT 166 Query: 184 ITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPR 243 I + G+ F + I + P Sbjct: 167 IVAELLGLPPMDHEQ--------------FGDWSGALVDIQMDDPTDP--------ALAE 204 Query: 244 EVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFI 303 + + L +K E D + ++ ++ +AL D E S + Sbjct: 205 RIADVLNPLTAYLKARCAERRADPGDDLISRLVLAEV-----DGRALDDEEAANFSTALL 259 Query: 304 FAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNET 363 AG+ TT+ +L I+ L HP E+ + +V E Sbjct: 260 LAGHITTTVLLGNIVRTLDEHPAHWDAAAEDPGR------------------IPAIVEEV 301 Query: 364 LRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKN 423 LR P +++R K E+ G+ IP V+V + +RD +P++F P R Sbjct: 302 LRYRPPFPQMQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSR----- 356 Query: 424 KDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLL 483 FG G C+G A + ++AL ++ F L+ +L Sbjct: 357 --KSGGAAQLSFGHGVHFCLGAPLARLENRVALEEIIARFGRLTVDRDDERLRHFEQIVL 414 Query: 484 QPEK-PVVLKVESRD 497 PV+ R Sbjct: 415 GTRHLPVLAGSSPRQ 429 >3WVS-A nrPDB Length = 401 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 71/420 (16%), Positives = 146/420 (34%), Gaps = 75/420 (17%) Query: 68 YG-KVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEW 126 YG W + L + D + + + + ++ + + Sbjct: 45 YGEPAWLATRYEDARLVLGDARFSRALSEEH------DPPRARKFNAQAKSMFNMDAPDH 98 Query: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186 RLR L+S FT +++E+ P + L+ ++ + G+P L + + Sbjct: 99 TRLRRLISKAFTIRRVEELRPKVHDLAHRLIDDMLAK---GEPADLVADYALPIPTTVIC 155 Query: 187 TSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVT 246 GV + +F LS + P E Sbjct: 156 ELLGVPFEDRE--------------KFGRWTDAILSTSTLN--------------PEEGR 187 Query: 247 NFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAG 306 + V + + D + MI++++ ++ L++ EL+ I + AG Sbjct: 188 VKRMELVGYIGGIIAARRAQPADDLISGMIEARDVQDK-----LTEQELLDHCIGLLIAG 242 Query: 307 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 366 +ETT+S + +Y L P ++L ++ E + V E R Sbjct: 243 HETTASQIPSFVYALLDQPQHWKRLLDD------------------PELIPSAVEELFRF 284 Query: 367 FPIAMR--LERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK 424 P+ R ++D+E+ G + G V++ A +RD + +PE+ +R S Sbjct: 285 VPLGSGSAAPRYAREDIEVGGTLVRAGEPVLVALGAANRDGLRFEDPEEIKLDRPSNH-- 342 Query: 425 DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQ 484 + FG G +C+G A + ++ AL +L+ P + + +++ Sbjct: 343 -------HIGFGHGIHHCLGAPLARLELQEALRALLERL---PTLKVAGDIAWKSEMMVR 392 >6GMF-A nrPDB Length = 397 Score = 204 bits (518), Expect = 1e-52, Method: Composition-based stats. Identities = 80/424 (18%), Positives = 139/424 (32%), Gaps = 75/424 (17%) Query: 75 YDGQQPVLAITDPDMIKTVLVK-ECYS----VFTNRRPFGPVGFMKSAISIAEDEEWKRL 129 Q +A+ + VL + +S + R M +I + +L Sbjct: 31 RLQPQGFMAVGRYQDVARVLHDAKGFSNRGWAASLPRGVKWDTSMPPSIVQVDPPRHGKL 90 Query: 130 RSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSF 189 R+L++ FT + ++ P I LV LR ++ V + M VI Sbjct: 91 RTLVTKAFTPRTVAQLEPRIRDIAHELVDGLRGKSTFEATVEVT---VPMPMIVIAEMLG 147 Query: 190 GVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFL 249 + F + ++ V N R F Sbjct: 148 VAPERRAD---------------------FKRWSDDMVGSLALVRVGNAAQLERSTQEFY 186 Query: 250 RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYET 309 E E ++ R D + ++ ++ E L+ E+++ + + AG ET Sbjct: 187 ----AYFSEVLEERRREPREDLISQLLAAEVDGEK-----LTAGEVLSFANTLLIAGNET 237 Query: 310 TSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPI 369 T+S++ + L HP+ Q + + + VV E LR Sbjct: 238 TTSLIGNALVALTDHPEQLAAAQAD------------------LSLVPAVVEEVLRYESP 279 Query: 370 AMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP 429 A + R DVEI IP VV+ + +RD + +P++F R +K Sbjct: 280 AQCIFRQTMTDVEIGDERIPARSVVLPLLASANRDESRFPDPDRFDIHRDTKG------- 332 Query: 430 YIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF----------SFKPCKETQIPLKLSL 479 + FG CIG A + K+ L +L S+ P + P L L Sbjct: 333 --HLAFGLDIHFCIGAPLARLEAKVMLEVLLARLGDIQRVSQEVSWSPSFFIRSPSTLPL 390 Query: 480 GGLL 483 + Sbjct: 391 RATV 394 >5LIE-A nrPDB Length = 414 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 67/393 (17%), Positives = 124/393 (31%), Gaps = 61/393 (15%) Query: 72 WGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRS 131 W + + + DP +V + +++ +D R+R Sbjct: 52 WSVATYAETLEVLRDPVTYSSV---TGGQRRFGGTVLQDLPVAGQVLNMMDDPRHTRIRR 108 Query: 132 LLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGV 191 L+S T ++ + + + L+ + G P A + GV Sbjct: 109 LVSSGLTPRMIRRVEDDLRRRARGLLDGVE----PGAPFDFVVEIAAELPMQMICILLGV 164 Query: 192 NIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPR-EVTNFLR 250 T + F+ ++P F PR V + Sbjct: 165 P-------------ETDRHWLFEAVEPGFD-----------FRGSRRATMPRLNVEDAGS 200 Query: 251 KSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETT 310 + E + D L ++ ++ ALSD EL + AG ETT Sbjct: 201 RLYTYALELIAGKRAEPADDMLSVVANATIDDP--DAPALSDAELYLFFHLLFSAGAETT 258 Query: 311 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA 370 + ++ + LA +PD Q L+ + E L + E +R + Sbjct: 259 RNSIAGGLLALAENPDQLQTLRSD------------------FELLPTAIEEIVRWTSPS 300 Query: 371 MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 430 R + V + G I G V++ + +RDP + ++F R P Sbjct: 301 PSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRADEFDITR---------KPN 351 Query: 431 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF 463 + FG G C+G A + +++ +L F Sbjct: 352 PHLGFGQGVHYCLGANLARLELRVLFEELLSRF 384 >3R9C-A nrPDB Length = 418 Score = 203 bits (517), Expect = 1e-52, Method: Composition-based stats. Identities = 67/378 (17%), Positives = 131/378 (34%), Gaps = 56/378 (14%) Query: 106 RPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAE 165 P ++ + + RLR L+S F +K + P I D L+ + Sbjct: 85 AETQPRPQGPASFLFLDPPDHTRLRGLVSKAFAPRVIKRLEPEITALVDQLLDAVDG--- 141 Query: 166 TGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITV 225 ++I + ++ + + + +E+ K R L L + Sbjct: 142 -------------PEFNLIDNLAYPLPVAVICRLLGVPIEDEPKFSRASALLAAALDPFL 188 Query: 226 FPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETE 285 + ++LR + + + E D + ++ + E Sbjct: 189 ALTGETSDLFDEQMKAGMWLRDYLRALIDERRRTPGE-------DLMSGLVAVE-----E 236 Query: 286 SHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPP 345 S L++ E++A + + AG+ETT ++++ + P L + Sbjct: 237 SGDQLTEDEIIATCNLLLIAGHETTVNLIANAALAMLRTPGQWAALAADGSRA------- 289 Query: 346 TYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDP 405 V+ ET+R P + R D+ I +PKG +++ A HRDP Sbjct: 290 -----------SAVIEETMRYDPPVQLVSRYAGDDLTIGTHTVPKGDTMLLLLAAAHRDP 338 Query: 406 KYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF-S 464 P++F P+R + + FG G C+G A + +AL + F Sbjct: 339 TIVGAPDRFDPDRAQIR---------HLGFGKGAHFCLGAPLARLEATVALPALAARFPE 389 Query: 465 FKPCKETQIPLKLSLGGL 482 + E + L+L G+ Sbjct: 390 ARLSGEPEYKRNLTLRGM 407 >3ABA-A nrPDB Length = 403 Score = 201 bits (510), Expect = 8e-52, Method: Composition-based stats. Identities = 76/416 (18%), Positives = 144/416 (34%), Gaps = 71/416 (17%) Query: 73 GFYDGQQPVLAITDPDMIKTVLVKECYSV-----FTNRRPFGPVGFMKSAISIAEDEEWK 127 F G + L T + ++ +L +SV + + ++ ++ E Sbjct: 38 TFTSGHEAWLV-TGYEEVRALLRDSSFSVQVPHALHTQDGVVTQKPGRGSLLWQDEPEHT 96 Query: 128 RLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITST 187 R LL+ FT +++ + P I + D +L G PV L F ++ S Sbjct: 97 SDRKLLAKEFTVRRMQALRPNIQRIVD---EHLDAIEARGGPVDLVKTFANAVPSMVISD 153 Query: 188 SFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTN 247 FGV + + F + + ++R D + + Sbjct: 154 LFGVPV----ERRAEFQDIAEAMMRVD------------------QDAAATEAAGMRLGG 191 Query: 248 FLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGY 307 L + V+ + + D + +I ++ + + D+ L+ + + A + Sbjct: 192 LLYQLVQERRAN-------PGDDLISALITTE-----DPDGVVDDMFLMNAAGTLLIAAH 239 Query: 308 ETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF 367 +TT+ ++ L PD L+E+ + V E LR Sbjct: 240 DTTACMIGLGTALLLDSPDQLALLRED------------------PSLVGNAVEELLRYL 281 Query: 368 PIAM-RLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426 I ERV +DVE+ G+ I KG V+ A DP + EPE+F R Sbjct: 282 TIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITR-------- 333 Query: 427 IDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGL 482 P + FG G CIG + A + +++ + + + L+ + Sbjct: 334 -RPAPHLAFGFGAHQCIGQQLARIELQIVFETLFRRLPGLRLAKPVEELRFRHDMV 388 >3A50-A nrPDB Length = 411 Score = 199 bits (507), Expect = 2e-51, Method: Composition-based stats. Identities = 75/393 (19%), Positives = 137/393 (34%), Gaps = 71/393 (18%) Query: 69 GKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKR 128 G VW A DP + K + + + + + + R Sbjct: 43 GPVWLLTRYADVREAFVDPRLSKDWRHRLPEDQRADMPATPT-----PMMILMDPPDHTR 97 Query: 129 LRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTS 188 LR L+ +FT ++ E+ P I + D L+ L G +++ + VI Sbjct: 98 LRKLVGRSFTVRRMNELEPRITEIADGLLAGL---PTDGPVDLMREYAFQIPVQVICELL 154 Query: 189 FGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNF 248 L + D F +V L+ + ++ + Sbjct: 155 ---------------------GLPAEDRDDFSAWSSV---LVDDSPADDKNAAMGKLHGY 190 Query: 249 LRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYE 308 L ++R + ++ S + LS ELVA +++ + AG+E Sbjct: 191 LSDLLERKRTEPD-----------DALLSSLLAVSDMDGDRLSQEELVAMAMLLLIAGHE 239 Query: 309 TTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP 368 TT +++ + L THPD ++ L E+ + V E LR Sbjct: 240 TTVNLIGNGVLALLTHPDQRKLLAED------------------PSLISSAVEEFLRFDS 281 Query: 369 IAMRLE-RVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNI 427 + R +DV +G+ IP G +VM+ A +RD + EP++ R + Sbjct: 282 PVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDASGG---- 337 Query: 428 DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVL 460 FG G C+G + A + ++A+ R+ Sbjct: 338 -----VFFGHGIHFCLGAQLARLEGRVAIGRLF 365 >2WM5-A nrPDB Length = 435 Score = 199 bits (505), Expect = 3e-51, Method: Composition-based stats. Identities = 55/361 (15%), Positives = 122/361 (33%), Gaps = 57/361 (15%) Query: 116 SAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDV 175 ++ + +D +RLRS++S FT + + + LV ++ + + ++ Sbjct: 115 GSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAAVRDRAHRLVSSMIANNPDRQADLVSEL 174 Query: 176 FGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEV 235 G + +I G+ L E Sbjct: 175 AGPLPLQIICDM-MGIPKADHQRIFH--------------WTNVILGFGDPDLATDFDEF 219 Query: 236 LNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLEL 295 + + ++ + + + + H D +++++ E LS E+ Sbjct: 220 MQVSA---DIGAYATALAEDRRVN-------HHDDLTSSLVEAEVDGE-----RLSSREI 264 Query: 296 VAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEY 355 + I+ + AG ETT + ++ + L+ +P+ + + + D + P Sbjct: 265 ASFFILLVVAGNETTRNAITHGVLALSRYPEQRDRWWSDFDGLAP--------------- 309 Query: 356 LDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFL 415 V E +R + + R +D+E+ G + G V + + +RD + +P F Sbjct: 310 --TAVEEIVRWASPVVYMRRTLTQDIELRGTKMAAGDKVSLWYCSANRDESKFADPWTFD 367 Query: 416 PERFSKKNKDNIDPYIYTPF-GSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474 R +P + F G G C+G A +++A + + E Sbjct: 368 LAR---------NPNPHLGFGGGGAHFCLGANLARREIRVAFDELRRQMPDVVATEEPAR 418 Query: 475 L 475 L Sbjct: 419 L 419 >6GK6-A nrPDB Length = 411 Score = 198 bits (504), Expect = 4e-51, Method: Composition-based stats. Identities = 74/421 (17%), Positives = 147/421 (34%), Gaps = 73/421 (17%) Query: 70 KVWGFYDGQQPVLAITDPDMIKTVL-----VKECYSVFTNRRPFGPVGFMKSAISIAEDE 124 +W V + DP +I+ V+ Y ++R FM + A+ Sbjct: 43 PIWVAVRYDDCVELLKDPRLIRDFRKLPDEVRRRYFPLSDRTT-----FMDQHMLDADPP 97 Query: 125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVI 184 + RLR+++ F+ ++ + P I + D L+ V M++I Sbjct: 98 DHTRLRAIVQRAFSPRMMEGLRPRIQEIADGLID---------------AVIDRRRMELI 142 Query: 185 TSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPRE 244 +F + + VE+ + R + +L F Sbjct: 143 ADFAFPLPTAVIAELLGLPVEDRGRFRR---------------WTKILLAPAKDREFVER 187 Query: 245 VTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIF 304 + + + + R D + ++ ++ + LS EL + + + Sbjct: 188 AQPVVEEFAAYFRALADARRKAPRDDLISGLLLAEEQEHK-----LSPAELSSMVFLLLV 242 Query: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETL 364 AG+ETT +++ M L +HP +++L E+ + V E L Sbjct: 243 AGHETTVHLIASGMLLLLSHPAERRRLDED------------------PGLVGSAVEEAL 284 Query: 365 RLF-PIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKN 423 R P + R +D+E+ G +P G V A +RDP+++ +P++F R Sbjct: 285 RCEGPAELSTIRWSLEDIELFGARVPAGEGVAAGLLAANRDPQHFPDPDRFDIGR----- 339 Query: 424 KDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLL 483 P + FG G C+G A + +A +L+ + + S + Sbjct: 340 ----SPNRHIGFGGGIHFCLGAMLARIEAAIAFSTLLRRLPRIELATSTRDIVWSEWPTI 395 Query: 484 Q 484 + Sbjct: 396 R 396 >4WPZ-A nrPDB Length = 397 Score = 198 bits (504), Expect = 4e-51, Method: Composition-based stats. Identities = 77/422 (18%), Positives = 155/422 (36%), Gaps = 76/422 (18%) Query: 83 AITDPDMIKTVLVKECYS------VFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPT 136 +T ++ VLV +S M ++ + E RLR L++ Sbjct: 41 MVTKHADVRKVLVDSRFSSKVMATAAAAMSETETGKLMNESLVGMDAPEHTRLRKLVTKA 100 Query: 137 FTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFG-AYSMDVITSTSFGVNIDS 195 FT+ +++ + P I + L+ L +PV L F + VI GV Sbjct: 101 FTARRVETLRPRITELVGQLLDELETLP---RPVDLVKNFSVPLPVRVICELL-GVPAGD 156 Query: 196 LNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKR 255 + F L +V+ + N+ + + Sbjct: 157 QDT--------------FHAWSNALLG--------DWQQVVEKEAATVSLVNYFGELIAV 194 Query: 256 MKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315 +E+ D + +I ++ L++ E++A SI + AG+ETT++ +S Sbjct: 195 KRENPA-------DDLISELIAI-----SDGDSTLTEREIIALSIGILSAGHETTANQIS 242 Query: 316 FIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMR--- 372 + L +P+ KL++ +A + V+E LR P+ Sbjct: 243 MFLVTLLHNPEELDKLRDNREA------------------IPKAVDELLRFVPLTTTGGI 284 Query: 373 LERVCKKDVEI-NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYI 431 + R+ +VE+ G +P G VV+ +RDP+ + + E+ R + Sbjct: 285 IPRLTTAEVELSGGQVLPAGAVVLPAVATANRDPEVFEDGERLNVTR---------ENNP 335 Query: 432 YTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVL 491 + FG+G +C+G + A + ++ AL +L + L+L +++ + + + Sbjct: 336 HLAFGAGIHHCLGAQLARIELQEALGAILDRMPQVRLAVPESELRLKSASIIRGLESLPI 395 Query: 492 KV 493 Sbjct: 396 TW 397 >1UED-A nrPDB Length = 406 Score = 198 bits (503), Expect = 5e-51, Method: Composition-based stats. Identities = 79/412 (19%), Positives = 135/412 (32%), Gaps = 78/412 (18%) Query: 85 TDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSA-------ISIAEDEEWKRLRSLLSPTF 137 ++++ +L FT R F IS + E RLR +L+P F Sbjct: 59 HGYEVVRRILGDH--EHFTTRPQFTQSKSGAHVEAQFVGQISTYDPPEHTRLRKMLTPEF 116 Query: 138 TSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTL-KDVFGAYSMDVITSTSFGVNIDSL 196 T +++ M P I D + L E + L D GA+++ + L Sbjct: 117 TVRRIRRMEPAIQSLIDDRLDLLEAEGPSADLQGLFADPVGAHAL-----------CELL 165 Query: 197 NNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRM 256 P+D E +++ R L + + F R + N L + Sbjct: 166 GIPRDDQREFVRRIRRNADLSRGLKA-----------RAADSAAFNRYLDNLLARQ---- 210 Query: 257 KESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSF 316 + D L MI + ++D EL I G ET + ++ F Sbjct: 211 --------RADPDDGLLGMIVR------DHGDNVTDEELKGLCTALILGGVETVAGMIGF 256 Query: 317 IMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRL-ER 375 + L +P + L E + + VVNE +R R Sbjct: 257 GVLALLDNPGQIELLFESPEKA------------------ERVVNELVRYLSPVQAPNPR 298 Query: 376 VCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPF 435 + KDV I+G I G V+ +RD +P+ R + + F Sbjct: 299 LAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDPDVLDANRAAVSD---------VGF 349 Query: 436 GSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEK 487 G G C+G A +++A + + F +K + P++ Sbjct: 350 GHGIHYCVGAALARSMLRMAYQTLWRRFPGLRLAVPIEEVKYRSAFVDCPDQ 401 >2Z36-A nrPDB Length = 413 Score = 197 bits (500), Expect = 1e-50, Method: Composition-based stats. Identities = 72/392 (18%), Positives = 134/392 (34%), Gaps = 75/392 (19%) Query: 84 ITDPDMIKTVLV---------KECYSVFT-NRRPFGPVGFMKSAISIAEDEEWKRLRSLL 133 ++ + + VL K+ + +FT + + + + E R + Sbjct: 51 VSGHEEARAVLADGRFSSDKRKDGFPLFTLDAATLQQLRSQPPLMLGMDGAEHSAARRPV 110 Query: 134 SPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNI 193 FT +L + P I D + ++ A +PV L ++ GV Sbjct: 111 IGEFTVKRLAALRPRIQDIVDHFIDDM--LATDQRPVDLVQALSLPVPSLVICELLGVPY 168 Query: 194 DSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSV 253 + FF S T +E E+ ++ + Sbjct: 169 TDHD---------------------FFQSRTTMMVSRTSMEDRRRAFA--ELRAYIDDLI 205 Query: 254 KRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSV 313 R + + D I Q + T L LV+ + + + AG+ETT+++ Sbjct: 206 TRKES-------EPGDDLFSRQIARQRQEGT-----LDHAGLVSLAFLLLTAGHETTANM 253 Query: 314 LSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRL 373 +S + L +HP+ ++ M V E LR F IA + Sbjct: 254 ISLGVVGLLSHPEQLTVVKANPGR------------------TPMAVEELLRYFTIADGV 295 Query: 374 E-RVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIY 432 R+ +DVEI G+ I G V++ + + DP + +P ER ++ + Sbjct: 296 TSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDPAVLDVERGARH---------H 346 Query: 433 TPFGSGPRNCIGMRFALMNMKLALIRVLQNFS 464 FG GP C+G A M +++ + + Sbjct: 347 LAFGFGPHQCLGQNLARMELQIVFDTLFRRIP 378 >4TRI-A nrPDB Length = 407 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 68/401 (16%), Positives = 142/401 (35%), Gaps = 68/401 (16%) Query: 100 SVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRN 159 +F++ P + +D + R L++ FT ++ + V I + D L+ Sbjct: 60 ELFSSTGGIRPDQPGMPYMIDMDDPQHLLRRKLVNAGFTRKRVMDKVDSIGRLCDTLIDA 119 Query: 160 LRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPF 219 + E G+ ++D+ M VI + T++ + + D Sbjct: 120 V---CERGECDFVRDIAAPLPMAVIGDMLGVLP--------------TERDMLLKWSDDL 162 Query: 220 FLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQ 279 L +++ + + K+ + + D ++++S+ Sbjct: 163 VCG----------LSSHVDEAAIQKLMDTFAAYTEFTKDVITKRRAEPTDDLFSVLVNSE 212 Query: 280 NSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL 339 + +SD E+V ++++ + G ETT LS +L H D L ++D Sbjct: 213 V-----EGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHRDQWDALVADVD--- 264 Query: 340 PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSY 399 L + E LR + R D +G + G +M+ Sbjct: 265 ---------------LLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRAGEKIMLMFE 309 Query: 400 ALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRV 459 + + D + +P+ F +R +P + FG G C+G + A + ++L RV Sbjct: 310 SANFDESVFGDPDNFRIDR---------NPNSHVAFGFGTHFCLGNQLARLELRLMTERV 360 Query: 460 LQNF-SFKPCKETQIPLK--------LSLGGLLQPEKPVVL 491 L+ + + +PL+ S+ + P PV+ Sbjct: 361 LRRLPDLRLADDAPVPLRPANFVSGPESMPVVFTPSAPVLA 401 >5EX6-C nrPDB Length = 434 Score = 196 bits (499), Expect = 1e-50, Method: Composition-based stats. Identities = 72/428 (16%), Positives = 136/428 (31%), Gaps = 84/428 (19%) Query: 69 GKVWGFYDGQ----QPVLAITDPDMIKTVLVKECY----------SVFTNRRPFGPVGFM 114 G++ G + T D+++ VL + F P + Sbjct: 62 GELTRVRLGSGADAEHTWLATGHDVVRQVLGDHTRFSTRRRFDRNDEIGGKGVFRPRELV 121 Query: 115 KSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKD 174 + + + E RLR LL+P FT K++ M P I Q + + RE G P L + Sbjct: 122 GN-LMDYDPPEHTRLRRLLAPGFTHRKIRRMAPYIEQIVTERLDEMERE---GSPADLIE 177 Query: 175 VFG-AYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPIL 233 +F V+ L P+D + R L L Sbjct: 178 LFADEVPGPVLCEL--------LGVPRDDRAMFLQLCHRH---------------LDASL 214 Query: 234 EVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDL 293 + +L V R + K D L M+ +++ ++D Sbjct: 215 SGRRRAAAGEAFSRYLVTMVARER--------KDPGDGLIGMVVAEH------GDTVTDE 260 Query: 294 ELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQM 353 EL + + AG + S ++ + L +P+ L+ ++ Sbjct: 261 ELRGVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAALRGDV------------------ 302 Query: 354 EYLDMVVNETLRLFPIAMR-LERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPE 412 + V+E +R + R +D + I G V+ +RDP + + Sbjct: 303 PAAERAVDELIRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDAD 362 Query: 413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ 472 + R + + FG G +C+G A + +++A + + F + Sbjct: 363 RLDVTR---------EAVPHVAFGHGVHHCLGAALARLELRIAYTALWRRFPDLRLADPD 413 Query: 473 IPLKLSLG 480 + L Sbjct: 414 GATEFRLS 421 >5DQN-A nrPDB Length = 426 Score = 196 bits (499), Expect = 2e-50, Method: Composition-based stats. Identities = 71/395 (17%), Positives = 128/395 (32%), Gaps = 69/395 (17%) Query: 111 VGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPV 170 V ++ + + + RLR ++S FT + + + + + A Sbjct: 92 VDLQRAVLLNMDAPQHTRLRKIISRGFTPRAIGRLED----ELRSRAQKIAQTAAAQGAG 147 Query: 171 TLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLI 230 + + GV D + E T Sbjct: 148 DFVEQVSCELPLQAIAELLGVPQDDRDKLFRWSNEMTAG-------------------ED 188 Query: 231 PILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKAL 290 P ++ + E+ ++ K + + E D + +I++ E L Sbjct: 189 PEYADVDPAMSSFELISYAMKMAEERAVNPTE-------DIVTKLIEADIDGEK-----L 236 Query: 291 SDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTV 350 SD E ++ AG ETT + ++ M A +PD + ++E Sbjct: 237 SDDEFGFFVVMLAVAGNETTRNSITHGMIAFAQNPDQWELYKKERP-------------- 282 Query: 351 LQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTE 410 + +E +R +R +DVE+ G+ I KG V++ + + D + + + Sbjct: 283 ------ETAADEIVRWATPVSAFQRTALEDVELGGVQIKKGQRVVMSYRSANFDEEVFED 336 Query: 411 PEKFLPERFSKKNKDNIDPYIYTPFGS-GPRNCIGMRFALMNMKLALIRVLQNF-SFKPC 468 P F R P + FG G CIG A M + L + N KP Sbjct: 337 PHTFNILR---------SPNPHVGFGGTGAHYCIGANLARMTINLIFNAIADNMPDLKPI 387 Query: 469 KETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGA 503 P +L G L + V + +VSGA Sbjct: 388 G---APERLKSGWLNGIKHWQVDYTGAGKASVSGA 419 >1Q5D-A nrPDB Length = 419 Score = 196 bits (497), Expect = 3e-50, Method: Composition-based stats. Identities = 87/454 (19%), Positives = 165/454 (36%), Gaps = 79/454 (17%) Query: 53 YHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPV- 111 Y + + ++ + +G +T + V E ++V +R + Sbjct: 24 YAEDPFPAIERLREA-TPIFYWDEG--RSWVLTRYHDVSAVFRDERFAV--SREEWESSA 78 Query: 112 ----------GFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLR 161 K + E+ R+R L++P+FTS + + I + D L+ Sbjct: 79 EYSSAIPELSDMKKYGLFGLPPEDHARVRKLVNPSFTSRAIDLLRAEIQRTVDQLLD--- 135 Query: 162 REAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFL 221 A +G+ DV+ + G+ + +++ E +K RF L Sbjct: 136 --ARSGQE----------EFDVVRDYAEGIPMRAISALLKVPAECDEKFRRFGSATARAL 183 Query: 222 SITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNS 281 + + P + + L V E L + + + LE+ D L +++ ++ Sbjct: 184 GVGLVPRVDEETKTLVASVT--EGLALLHGVLDERRRNPLEN------DVLTMLLQAEA- 234 Query: 282 KETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN 341 LS ELVA I AG +TT +++F + L P+ + ++ E Sbjct: 235 ----DGSRLSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEALELVKAE------- 283 Query: 342 KAPPTYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYA 400 + ++E LR I + R ++D+E G I KG +V + + Sbjct: 284 -----------PGLMRNALDEVLRFDNILRIGTVRFARQDLEYCGASIKKGEMVFLLIPS 332 Query: 401 LHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVL 460 RD ++ P+ F R D +G GP C G+ A + ++A+ + Sbjct: 333 ALRDGTVFSRPDVFDVRR---------DTSASLAYGRGPHVCPGVSLARLEAEIAVGTIF 383 Query: 461 QNFSFKPCKETQI-------PLKLSLGGLLQPEK 487 + F KET + SL +L+P K Sbjct: 384 RRFPEMKLKETPVFGYHPAFRNIESLNVILKPSK 417 >5Y1I-A nrPDB Length = 403 Score = 196 bits (497), Expect = 3e-50, Method: Composition-based stats. Identities = 68/410 (16%), Positives = 142/410 (34%), Gaps = 69/410 (16%) Query: 72 WGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRS 131 W ++DP + L ++ Y + F + + + + +D E R+R Sbjct: 45 WVVTRHADQRALLSDPRVSHDGL-RDGYPHIS--ADFKFLSMAQPSFAGQDDPEHGRIRR 101 Query: 132 LLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGV 191 +++ FT+ +++ M P I + D L+ + KPV L + + GV Sbjct: 102 MVTLPFTARRIEAMRPAIQKITDELIDGM---LAGPKPVDLVEALALPVPVRVICEMLGV 158 Query: 192 NIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRK 251 F++ + + + Sbjct: 159 PY-----EDREFLQQNNNAMIY------------------------RDTAQGDAQKAAIA 189 Query: 252 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTS 311 +KE D L + + E ++ + ++ + AG+ETT+ Sbjct: 190 QAMYLKELVGTKLGDRGDDILSDLAVQVEAGE------ITQDDAAGIGMMLLGAGHETTA 243 Query: 312 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAM 371 ++++ L +P+ ++++ D + + V E LR IA Sbjct: 244 NMIALGTLALLENPEQLAEVRDSDD----------------PKVIVNTVEELLRYLTIAQ 287 Query: 372 -RLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTE-PEKFLPERFSKKNKDNIDP 429 + R+ +D+EI G+ I G ++ P A + DP + E P++ R + + Sbjct: 288 DTVRRIAAEDIEIGGVVIKAGEGIVFPLNAANWDPDLYPEAPDRLDIHRANARR------ 341 Query: 430 YIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET--QIPLKL 477 + FG G C+G A + +++ +L+ T +IP K Sbjct: 342 --HLAFGYGVHQCLGATLARVELQIVYSTLLRRIPTLALAGTLDEIPFKH 389 >5NWS-A nrPDB Length = 435 Score = 195 bits (496), Expect = 3e-50, Method: Composition-based stats. Identities = 73/441 (16%), Positives = 156/441 (35%), Gaps = 79/441 (17%) Query: 56 GFCMFDMECHKKYGKVWGFYDG-QQPVLAITDPDMIKTVLVKECY---------SVFTNR 105 ++ G V PV +T D ++ VL + + Sbjct: 35 DPFTGYGRLRER-GPVVRGRFVDGTPVWFVTRYDDVRAVLRDPRFVNTPSPVPGEGGADP 93 Query: 106 R---------PFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVL 156 R P ++ +I ++ + RLR L++ F + ++ + P I + D L Sbjct: 94 REGMMDLLNVPEPLRVYLLGSILDSDPPDHPRLRRLVTRAFAARRILGLRPGIERIADRL 153 Query: 157 VRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFL 216 + L R E V L + F + G+ L R+ Sbjct: 154 LAELPRREEEDGTVDLLEHFAYPLSITVICELVGIPATDLE--------------RWREW 199 Query: 217 DPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMI 276 +S+ + + ++ + +++ + + D L +I Sbjct: 200 GGDLVSM----------RPERLRHSFPVMIDYCHRLIEQRRAALT-------DDLLSELI 242 Query: 277 DSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEID 336 +Q+ + LSD+E V + + AG+ET++ ++ L THP L+++ Sbjct: 243 RAQD----DDGGRLSDIETVTMILTLVLAGHETSAHLIGNGTAALLTHPGQWALLRKD-- 296 Query: 337 AVLPNKAPPTYDTVLQMEYLDMVVNETLRLF-PIAMRLERVCKKDVEINGMFIPKGVVVM 395 L V+E +R + + R +D+E+ G + +G V Sbjct: 297 ----------------PALLPRAVHELMRWCGSVHVARLRYATEDLELAGTPVARGDAVQ 340 Query: 396 IPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLA 455 + + + DP+++++P++ R + +N + FG G C+G A ++A Sbjct: 341 LVLVSANFDPRHYSDPDRLDITRHQEGQAEN-----HVGFGHGIHYCLGATLARQEGEVA 395 Query: 456 LIRVLQNFSFKPCKETQIPLK 476 L R+L+ + + ++ Sbjct: 396 LARLLETYPDLALADGDPEVR 416 >1ODO-A nrPDB Length = 408 Score = 195 bits (495), Expect = 4e-50, Method: Composition-based stats. Identities = 81/398 (20%), Positives = 135/398 (33%), Gaps = 66/398 (16%) Query: 83 AITDPDMIKTVL-VKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGK 141 +T D+ K + P +++ A ++LR L++P F++ + Sbjct: 52 LLTSSDVSKDARAHWPAFGEVVGTWPLALWVAVENMF-TAYGPNHRKLRRLVAPAFSARR 110 Query: 142 LKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQD 201 + M P + LV L E G+PV L+ + GV D Sbjct: 111 VDAMRPAVEAMVTGLVDRL-AELPAGEPVDLRQELAYPLPIAVIGHLMGVPQD------- 162 Query: 202 PFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRL 261 + + L D + EVL+ + + T Sbjct: 163 --RRDGFRALVDGVFDTTLDQAEAQANTARLYEVLDQLIAAKRAT--------------- 205 Query: 262 EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYEL 321 D L+I +++ + LS EL ++ I AGYETT +V+ ++ L Sbjct: 206 -----PGDDMTSLLIAARDDEG--DGDRLSPEELRDTLLLMISAGYETTVNVIDQAVHTL 258 Query: 322 ATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLE-RVCKKD 380 T PD +++ T+ VV ETLR P L R D Sbjct: 259 LTRPDQLALVRK---------GEVTWAD---------VVEETLRHEPAVKHLPLRYAVTD 300 Query: 381 VEI-NGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGP 439 + + +G I +G ++ A +R P + + + F R K+ + FG G Sbjct: 301 IALPDGRTIARGEPILASYAAANRHPDWHEDADTFDATRTVKE---------HLAFGHGV 351 Query: 440 RNCIGMRFALMNMKLALIRVLQNF---SFKPCKETQIP 474 C+G A M + LAL + F E P Sbjct: 352 HFCLGAPLARMEVTLALESLFGRFPDLRLADPAEELPP 389 >5Z9I-A nrPDB Length = 398 Score = 195 bits (495), Expect = 5e-50, Method: Composition-based stats. Identities = 67/405 (16%), Positives = 147/405 (36%), Gaps = 59/405 (14%) Query: 70 KVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRL 129 ++W Y + +++P V + + + V + + + + +RL Sbjct: 34 QLWNVYGYPESAAILSNPK----VFSSDTMRLDPIKLDEAIV---EGDFAHTDPPKHRRL 86 Query: 130 RSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSF 189 R L+ FT + +M + L+ + +++ L F A ++ S Sbjct: 87 RGLVDHAFTPSLVAKMESRVHGIIHELLDGVEGKSQ----FDLVAEFAAPLPLIMISDLL 142 Query: 190 GVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFL 249 GV + + F + K+L D + F TV + + L + R+ + Sbjct: 143 GVP----ESDRALFRQWMDKML--DGSEKFESPETVLEQEEELHKELELLWEMRDYWH-- 194 Query: 250 RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYET 309 E E ++ R D + ++ ++ + L+D ++ + + G+ T Sbjct: 195 --------ERAAESRKRPREDLISQLVHAEV-----DGQKLNDSQISNIANRLLVNGHLT 241 Query: 310 TSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPI 369 T+ +++ M L D +++ + + ++ E++R Sbjct: 242 TAMLIANTMLCLDAFSDQDARVRADR------------------SLVPALLEESMRYMSP 283 Query: 370 AMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP 429 + R +VE+ G IPK ++++ + A +RD + + +P+ F R P Sbjct: 284 ICGVGRATNSEVEVAGTVIPKDQLLLVWTGAANRDERQFEKPDVFDAGR---------SP 334 Query: 430 YIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474 + FG G C+G + A M K A+ +L P Sbjct: 335 NAHLGFGRGIHFCLGRQLARMESKAAVEILLDRLPTLRADPANPP 379 >3ABB-A nrPDB Length = 408 Score = 194 bits (492), Expect = 8e-50, Method: Composition-based stats. Identities = 74/422 (17%), Positives = 132/422 (31%), Gaps = 74/422 (17%) Query: 78 QQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFM---KSAISI----AEDEEWKRLR 130 +P IT + +LV S F V + ++ +D R R Sbjct: 47 GRPAWLITGHAEGRALLVDPRLSSDWGHPDFPVVVRRTEDRGGLAFPLIGVDDPVHARQR 106 Query: 131 SLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFG 190 +L P+F ++ + P + D L+ ++ + L F V G Sbjct: 107 RMLIPSFGVKRMNAIRPRLQSLVDRLLDDMLAKGPGA---DLVSAFALPVPSVAICELLG 163 Query: 191 VNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLR 250 V + F E Sbjct: 164 VPYGDHD------------------------------FFEECSRNFVGAATSAEADAAFG 193 Query: 251 KSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETT 310 + + + L +I Q + L E+V +++ + AG+ETT Sbjct: 194 ELYTYLHGLVGRKQAEPEDGLLDELIARQLEEGD-----LDHDEVVMIALVLLVAGHETT 248 Query: 311 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA 370 + ++ L HP+ L + AV VV E LR ++ Sbjct: 249 VNAIALGALTLIQHPEQIDVLLRDPGAVSG------------------VVEELLRFTSVS 290 Query: 371 MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 430 + R+ K+D+E+ G I G V++ ++RD K + P+ F R ++ Sbjct: 291 DHIVRMAKEDIEVGGATIKAGDAVLVSITLMNRDAKAYENPDIFDARRNARH-------- 342 Query: 431 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET--QIPLKLSLGGLLQPEKP 488 + FG G C+G A +++AL + ++P+K E P Sbjct: 343 -HVGFGHGIHQCLGQNLARAELEIALGGLFARIPGLRLAVPLDEVPIKAGHDAQGPIELP 401 Query: 489 VV 490 VV Sbjct: 402 VV 403 >6CVC-A nrPDB Length = 433 Score = 193 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 60/361 (16%), Positives = 117/361 (32%), Gaps = 57/361 (15%) Query: 116 SAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDV 175 ++ + +D +RLRS++S FT + + + + LV + G+ + ++ Sbjct: 112 GSMIVLDDPRHQRLRSIVSRAFTPKVVARIEASVRERAHRLVAAMIENHPDGQADLVSEL 171 Query: 176 FGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEV 235 G + +I G+ + L E Sbjct: 172 AGPLPLQIICDM-MGIPEEDHEQIFH--------------WTNVILGFGDPDLTTDFDEF 216 Query: 236 LNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLEL 295 L + + L + H D +++++ E LS E+ Sbjct: 217 LQVSMAIGGYATALAD----------DRRVNHHGDLTTSLVEAEVDGE-----RLSSSEI 261 Query: 296 VAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEY 355 I+ + AG ETT + +S M L+ +PD + K + D Sbjct: 262 AMFFILLVVAGNETTRNAISHGMLALSRYPDERAKWWSDFDG-----------------L 304 Query: 356 LDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFL 415 V E +R + + R +DV++ G + G V + + +RD + + +P F Sbjct: 305 AATAVEEIVRWASPVVYMRRTLSQDVDLRGTKMAAGDKVTLWYCSANRDEEKFADPWTFD 364 Query: 416 PERFSKKNKDNIDPYIYTPF-GSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474 R +P F G G C+G A +++ + + E Sbjct: 365 VTR---------NPNPQVGFGGGGAHFCLGANLARREIRVVFDELRRQMPDVVATEEPAR 415 Query: 475 L 475 L Sbjct: 416 L 416 >1LG9-A nrPDB Length = 398 Score = 193 bits (489), Expect = 2e-49, Method: Composition-based stats. Identities = 69/407 (16%), Positives = 132/407 (32%), Gaps = 72/407 (17%) Query: 83 AITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKL 142 + D T + + F P + + + + E RLR L+P FT K+ Sbjct: 54 VMGDHQQFSTRRRWDPRDEIGGKGIFRPRELVGN-LMDYDPPEHTRLRRKLTPGFTLRKM 112 Query: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDP 202 + M P I Q + + + R G P L + GV D + Sbjct: 113 QRMAPYIEQIVNDRLDEMER---AGSPADLIAFVADKVPGAVLCELVGVPRDDRDMFMK- 168 Query: 203 FVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLE 262 L LD L + + +L + R ++ E Sbjct: 169 --------LCHGHLDA-------------SLSQKRRAALGDKFSRYLLAMIARERKEPGE 207 Query: 263 DTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELA 322 MI + ++ + +D EL + + AG + S ++ + + Sbjct: 208 G-----------MIGAVVAEYGDDA---TDEELRGFCVQVMLAGDDNISGMIGLGVLAML 253 Query: 323 THPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMR-LERVCKKDV 381 HP+ + + + V+E +R + R+ ++D+ Sbjct: 254 RHPEQIDAFRGDEQSA------------------QRAVDELIRYLTVPYSPTPRIAREDL 295 Query: 382 EINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441 + G I KG V+ A +RDP + ++ R +P + FG G + Sbjct: 296 TLAGQEIKKGDSVICSLPAANRDPALAPDVDRLDVTR---------EPIPHVAFGHGVHH 346 Query: 442 CIGMRFALMNMKLALIRVLQNFS----FKPCKETQIPLKLSLGGLLQ 484 C+G A + ++ + + F P ++T+ L GL + Sbjct: 347 CLGAALARLELRTVFTELWRRFPALRLADPAQDTEFRLTTPAYGLTE 393 >4Z5Q-A nrPDB Length = 423 Score = 192 bits (488), Expect = 3e-49, Method: Composition-based stats. Identities = 81/463 (17%), Positives = 163/463 (35%), Gaps = 80/463 (17%) Query: 39 PGPTPLPFLGNI-LSYHKGFCMFDMECHKKYGKVWGFYD-GQQPVLAITDPDMIKTVLVK 96 P P PF G+ L + + + G +P +T D + VL Sbjct: 33 PAPVAYPFTGSEGLELSQSYAKLFED-----GDPIRVQLPFGEPAWLVTRYDDARFVLTD 87 Query: 97 ECYSVFTNRRPFGPV---GFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYG 153 +S + P + +I + + RLR+L+S FT +++ I + Sbjct: 88 RRFSRHLATQRDEPRMTPRAVPESILTMDPPDHTRLRTLVSKAFTPRRIESKRAWIGELA 147 Query: 154 DVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRF 213 LV +++ + V + A + VI GV D + Sbjct: 148 AGLVADMKAGGAPAELVGSYAL--AIPVTVICELL-GVPEDDRTRLRGWCDAALSTGELT 204 Query: 214 DFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQ 273 D E K ++ E + R D Sbjct: 205 D----------------------------EECVQSFMDLQKYFEDLVKERRAEPRDDLTS 236 Query: 274 LMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQE 333 +I+++ ++H L++ EL+ I + G+ETT+S +S ++ L ++ +L Sbjct: 237 ALIEAR-----DAHDRLAEPELIGLCISILIGGFETTASEISSFVHVLQQRRELWTRLCA 291 Query: 334 EIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMR--LERVCKKDVEINGMFIPKG 391 + +A + V E LR P A R +D+ + G+ + +G Sbjct: 292 DPEA------------------IPAAVEELLRFVPFAANGISPRYALEDMTVGGVLVREG 333 Query: 392 VVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMN 451 V++ + A++RD + ++ + +R + + FG G +C+G A + Sbjct: 334 EPVIVDTSAVNRDGLVFDNADEVVIDRADNR---------HMVFGHGAHHCLGAHLARVE 384 Query: 452 MKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVE 494 ++ AL +++ P ++ +++ P V+ VE Sbjct: 385 LQEALKALVEGM---PGLRLSGDVEWKADMIIR--APRVMHVE 422 >4MM0-A nrPDB Length = 399 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 75/406 (18%), Positives = 144/406 (35%), Gaps = 65/406 (16%) Query: 78 QQPVLAITDPDMIKTVLVKECYSVFTNRRPFG-PVGFMKSAISIAEDEEWKRLRSLLSPT 136 P +T + ++ VL +SV + ++ + RLR LLS Sbjct: 44 GDPGFLVTRYEDVRFVLSDPRFSVRQDLPGAPRLTEMTFESVMTTDPPVHTRLRRLLSRD 103 Query: 137 FTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSL 196 FT+ +++ M P + + + L+ + ++ G P + + + GV + + Sbjct: 104 FTARRIERMRPRLEEIAEGLLDEMEKK---GAPADIVESLAVPFPITVICELLGVPMVDV 160 Query: 197 NNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRM 256 RF +S+T + + + + ++L V Sbjct: 161 A--------------RFRGWADTMVSLTGYS-------MEDWTAARDALESYLDGLVAAK 199 Query: 257 KESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSF 316 +E+ D L ++ + L+D ++ + S+I + AGYE S+ L Sbjct: 200 REN-------PGSDLLSALVATAA-----EDNELTDHDVRSLSLILLLAGYEPASNQLGS 247 Query: 317 IMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMR-LER 375 + L PD +L+ + L V E +R P L R Sbjct: 248 SVLTLLRFPDRLAELRRD------------------PGLLPSAVEELMRYAPAGDGALFR 289 Query: 376 VCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPF 435 V +DV I IP V+ + A + DP+ + +P +R +T Sbjct: 290 VTLEDVTIGDTHIPANSAVLASTQAANWDPRRFDDPTGLRLDRPD---------NQHTAL 340 Query: 436 GSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGG 481 G G C+G A + +++A+ +L+ F + L+ S G Sbjct: 341 GHGIHFCLGAALARVELQVAIGALLRRFPRLALATDESGLRWSSPG 386 >6FSH-A nrPDB Length = 398 Score = 192 bits (487), Expect = 3e-49, Method: Composition-based stats. Identities = 63/402 (15%), Positives = 125/402 (31%), Gaps = 70/402 (17%) Query: 73 GFYDGQQPVL--AITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLR 130 + V+ + D T + + F P + + + + E RLR Sbjct: 42 TWLAAGHAVVRQVLGDHQQFSTRRRWDPRDEIGGKGIFRPRELVGN-LMDYDPPEHTRLR 100 Query: 131 SLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFG 190 LL+P FT +++ + P I + L + G P L ++F + G Sbjct: 101 HLLTPGFTQRRMRRLAPRIEEIVT---DRLDAMEQAGPPADLIELFADEVPGAVLCELIG 157 Query: 191 VNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLR 250 V D + L LD L + + +L Sbjct: 158 VPRDDRDMFMK---------LCHGHLDA-------------SLSQKRRAALGDKFSRYLL 195 Query: 251 KSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETT 310 + R + + F+ ++ E ++D EL + + AG + Sbjct: 196 AMIARER-------KDPGDGFIGSIV-------AEHGDTITDEELRGVCVQLMLAGDDNV 241 Query: 311 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA 370 S ++ + L HP+ L+ + + D V+E +R + Sbjct: 242 SGMIGLGVLALLRHPEQIAALRGDDQSA------------------DRAVDELIRYLTVP 283 Query: 371 MR-LERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP 429 R +DV + I +G V+ +RD + ++ R P Sbjct: 284 YAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTR---------TP 334 Query: 430 YIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKET 471 + FG G +C+G + +++A + + F + Sbjct: 335 VPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADP 376 >1EHE-A nrPDB Length = 403 Score = 191 bits (485), Expect = 6e-49, Method: Composition-based stats. Identities = 68/414 (16%), Positives = 128/414 (30%), Gaps = 67/414 (16%) Query: 78 QQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTF 137 + V + + + V ++ + + K + E RS++ PTF Sbjct: 48 HKDVCFVATSEKLSKVRTRQGFPELSASGKQA--AKAKPTFVDMDPPEHMHQRSMVEPTF 105 Query: 138 TSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLN 197 T +K + P I + D L+ ++++ PV L F I T GV + L Sbjct: 106 TPEAVKNLQPYIQRTVDDLLEQMKQKGCANGPVDLVKEFALPVPSYIIYTLLGVPFNDLE 165 Query: 198 NPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMK 257 T +E+ ++L V++ Sbjct: 166 YLTQQNAIRTNG----------------------SSTAREASAANQELLDYLAILVEQRL 203 Query: 258 ESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFI 317 + + D + + E + + V + + + AG T ++++ Sbjct: 204 V-------EPKDDIISKL-----CTEQVKPGNIDKSDAVQIAFLLLVAGNATMVNMIALG 251 Query: 318 MYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPI-AMRLERV 376 + LA HPD +L+ V E R A+ ++R Sbjct: 252 VATLAQHPDQLAQLKA------------------NPSLAPQFVEELCRYHTASALAIKRT 293 Query: 377 CKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFG 436 K+DV I + ++ + + +RD + + P++F R P FG Sbjct: 294 AKEDVMIGDKLVRANEGIIASNQSANRDEEVFENPDEFNMNR-------KWPPQDPLGFG 346 Query: 437 SGPRNCIGMRFALMNMKLALIRVLQNF-SFKPCKETQ----IPLKLSLGGLLQP 485 G CI A + + Q F K PL +G + P Sbjct: 347 FGDHRCIAEHLAKAELTTVFSTLYQKFPDLKVAVPLGKINYTPLNRDVGIVDLP 400 >5YSW-A nrPDB Length = 441 Score = 191 bits (484), Expect = 7e-49, Method: Composition-based stats. Identities = 74/427 (17%), Positives = 137/427 (32%), Gaps = 86/427 (20%) Query: 69 GKVWGFYDG-QQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPV---------------G 112 G V P ++ + + VL +S ++R + P Sbjct: 64 GPVARATLAAGDPFWLVSGYEEARAVLSDPRFS--SDRFQYHPWFKELSPEFRERLRDDK 121 Query: 113 FMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTL 172 + + E R R LL+ FT +++E+ I + V G L Sbjct: 122 ARAGSFINMDPPEHTRYRKLLTGQFTVRRIRELGARIDEIVAGRVD---AMLAGGTTADL 178 Query: 173 KDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPI 232 F + ++ GV + Q + Sbjct: 179 MTEFAFPAPSLMICELLGVRYEDRAEFQQRASALLQMNA--------------------- 217 Query: 233 LEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSD 292 V + F++ V + + D + +I + AL+D Sbjct: 218 -PVAEAVKNADALRAFMQALVTDKRANPAG-------DIISGLIHHAGADP-----ALTD 264 Query: 293 LELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQ 352 EL+ + + + AGY+TT+S+L ++ L P L+++ + Sbjct: 265 DELINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDDPSRIAD------------ 312 Query: 353 MEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEP 411 V E LR + + R K+D+E G IP G V++ A +RD ++W +P Sbjct: 313 ------AVEELLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHWPDP 366 Query: 412 EKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS--FKPCK 469 + R + FG G C+G + A M M+ +L+ Sbjct: 367 D-LDLTRPRG---------PHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRLAVP 416 Query: 470 ETQIPLK 476 ++PL+ Sbjct: 417 PEEVPLR 423 >3TYW-A nrPDB Length = 417 Score = 191 bits (484), Expect = 7e-49, Method: Composition-based stats. Identities = 70/412 (16%), Positives = 137/412 (33%), Gaps = 73/412 (17%) Query: 70 KVWGFYDGQQPVL-AITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSA-------ISIA 121 V + +T D ++ +L S R F +G + Sbjct: 43 PVARVTLPTRREAWVVTRYDDVRELLSDPRVSADIRRPGFPALGEGEQEAGARFRPFIRT 102 Query: 122 EDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSM 181 + E R R +L P FT +++ M P + D L G PV L + Sbjct: 103 DAPEHTRYRRMLLPAFTVRRVRAMRPAVQARVD---EILDGMLAAGGPVDLVSAYANAVS 159 Query: 182 DVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVF 241 + G+ L +D + + Sbjct: 160 TSVICELLGIPRHDLEFFRDVTRISGSRN-----------------------------ST 190 Query: 242 PREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSII 301 +V+ L + E ++ R D + ++ ++ +L++ I Sbjct: 191 AEQVSEALGGLFGLLGGLVAERREEPRDDLISKLVTDHLVP-----GNVTTEQLLSTLGI 245 Query: 302 FIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVN 361 I AG ETT+S+++ L P++ +L+++ D + V+ Sbjct: 246 TINAGRETTTSMIALSTLLLLDRPELPAELRKDPD------------------LMPAAVD 287 Query: 362 ETLRLFPIAMRLE-RVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS 420 E LR+ +A + RV +D+E++G +P V+ + DP+ + +PE+ R Sbjct: 288 ELLRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHRTD 347 Query: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ 472 + FG G C+G A + +++AL +L+ + Sbjct: 348 NH---------HVAFGYGVHQCVGQHLARLELEVALETLLRRVPTLRLAGER 390 >5XJN-A nrPDB Length = 455 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 68/423 (16%), Positives = 140/423 (33%), Gaps = 74/423 (17%) Query: 83 AITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKS---------------AISIAEDEEWK 127 +T D IKT + + F++ PV +S E Sbjct: 87 VVTKYDDIKTTF--DDWETFSSENAQAPVRKRGPQATQIMTDGGFTAYSGLSARIPPEHT 144 Query: 128 RLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITST 187 R+R++ FT + K + P I + + + + V D+++ Sbjct: 145 RIRAIAQKAFTPRRYKALEPDIRAMV---IDRVEKMLANDQHVG----------DMVSDL 191 Query: 188 SFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTN 247 ++ + ++ + R+ L + Sbjct: 192 AYDIPTITILTLIGADISMVDTYKRWSDSRAAMTWGD--------LSDEEQIPHAHNLVE 243 Query: 248 FLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGY 307 + ++ + + ++ D ++ + + ++D E+ + +FAG+ Sbjct: 244 YWQECQRMVADAHAHGGDNLTADLVRA---------QQEGQEITDHEIASLLYSLLFAGH 294 Query: 308 ETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF 367 ETT++++S L HP+ Q + E + + V+E LR Sbjct: 295 ETTTTLISNCFRVLLDHPEQWQAILE------------------NPKLIPAAVDEVLRYS 336 Query: 368 PIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNI 427 + R KD EI G+ I +G V++ + +RD + E+F R + + Sbjct: 337 GSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEFDISRANARE---- 392 Query: 428 DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLSLGGLLQPE 486 + FG G C+G A + K+ L V + S + I + +L + Sbjct: 393 ----HLSFGFGIHYCLGNMLAKLQAKICLEEVTRLVPSLHLVADKAIGFRENLSFRVPTS 448 Query: 487 KPV 489 PV Sbjct: 449 VPV 451 >5GWE-A nrPDB Length = 405 Score = 190 bits (482), Expect = 1e-48, Method: Composition-based stats. Identities = 68/423 (16%), Positives = 140/423 (33%), Gaps = 74/423 (17%) Query: 83 AITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKS---------------AISIAEDEEWK 127 +T D IKT + + F++ PV +S E Sbjct: 37 VVTKYDDIKTTF--DDWETFSSENAQAPVRKRGPQATQIMTDGGFTAYSGLSARIPPEHT 94 Query: 128 RLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITST 187 R+R++ FT + K + P I + + + + V D+++ Sbjct: 95 RIRAIAQKAFTPRRYKALEPDIRAMV---IDRVEKMLANDQHVG----------DMVSDL 141 Query: 188 SFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTN 247 ++ + ++ + R+ L + Sbjct: 142 AYDIPTITILTLIGADISMVDTYKRWSDSRAAMTWGD--------LSDEEQIPHAHNLVE 193 Query: 248 FLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGY 307 + ++ + + ++ D ++ + + ++D E+ + +FAG+ Sbjct: 194 YWQECQRMVADAHAHGGDNLTADLVRA---------QQEGQEITDHEIASLLYSLLFAGH 244 Query: 308 ETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF 367 ETT++++S L HP+ Q + E + + V+E LR Sbjct: 245 ETTTTLISNCFRVLLDHPEQWQAILE------------------NPKLIPAAVDEVLRYS 286 Query: 368 PIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNI 427 + R KD EI G+ I +G V++ + +RD + E+F R + + Sbjct: 287 GSIVGWRRKALKDTEIGGVAIKEGDGVLLLMGSANRDEARFENGEEFDISRANARE---- 342 Query: 428 DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLSLGGLLQPE 486 + FG G C+G A + K+ L V + S + I + +L + Sbjct: 343 ----HLSFGFGIHYCLGNMLAKLQAKICLEEVTRLVPSLHLVADKAIGFRENLSFRVPTS 398 Query: 487 KPV 489 PV Sbjct: 399 VPV 401 >3NC3-A nrPDB Length = 441 Score = 189 bits (481), Expect = 2e-48, Method: Composition-based stats. Identities = 78/393 (19%), Positives = 148/393 (37%), Gaps = 42/393 (10%) Query: 88 DMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLS--PTFTSGKLKEM 145 ++ Y+ F+ R PV + +S I + +R +L FT+ L E Sbjct: 45 SVLSDQFQNNPYAYFSQLREEDPVHYEES-IDSYFISRYHDVRYILQHPDIFTTKSLVER 103 Query: 146 VPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVE 205 + + G VL + +E + + ++ G D + S + ++ N P++E Sbjct: 104 AEPVMR-GPVLAQMHGKEHSAKRRIVVRSFIG----DALDHLSPLIKQNA-ENLLAPYLE 157 Query: 206 NTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSV------------ 253 K L DF F + +T+ + + I + V +F+ Sbjct: 158 RGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSGVADFITSISQSPEARAHSLWC 217 Query: 254 -KRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSS 312 +++ + + ++ RV+ +I + E E ALSD +++A + + A E Sbjct: 218 SEQLSQYLMPVIKERRVNPGSDLISILCTSEYE-GMALSDKDILALILNVLLAATEPADK 276 Query: 313 VLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMR 372 L+ ++Y L +P+ + + + + ETLR P Sbjct: 277 TLALMIYHLLNNPEQMNDVLADR------------------SLVPRAIAETLRYKPPVQL 318 Query: 373 LERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER-FSKKNKDNIDPYI 431 + R +D + GM I K +V A +RDP+ + +P+ F R Sbjct: 319 IPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIKSAFSGAAR 378 Query: 432 YTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS 464 + FGSG NC+G FA +++ VL Sbjct: 379 HLAFGSGIHNCVGTAFAKNEIEIVANIVLDKMR 411 >3RWL-A nrPDB Length = 426 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 65/412 (15%), Positives = 127/412 (30%), Gaps = 72/412 (17%) Query: 68 YGKVWGFYDGQQPVLAITDPDMIKT------VLVKECYSVFTNRRPFGPVGFMKSAISIA 121 +G W + T+ D+ + +++ + + P Sbjct: 61 FGPYWSITKYNDIMHVDTNHDIFSSDAGYGGIIIDDGIQKGGDGGLDLP------NFIAM 114 Query: 122 EDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSM 181 + R +SP L + I + + L G+ D Sbjct: 115 DRPRHDEQRKAVSPIVAPANLAALEGTIRERVSKTLDGL----PVGEEFDWVDRVSIEIT 170 Query: 182 DVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVF 241 + +T F E +KL R+ + V L C Sbjct: 171 TQMLATLFDFPF-----------EERRKLTRWSDVTTAAPGGGVVESWDQRKTELLECAA 219 Query: 242 PREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSII 301 +V + D + ++ S + + ++ E + ++ Sbjct: 220 YFQVLWN------------ERVNKDPGNDLISMLAHS------PATRNMTPEEYLGNVLL 261 Query: 302 FIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVN 361 I G +TT + ++ + L +PD KL+ ++ +V Sbjct: 262 LIVGGNDTTRNSMTGGVLALHKNPDQFAKLKA------------------NPALVETMVP 303 Query: 362 ETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421 E +R + R D E+ G I KG V++ Y+ +RD + PE+F+ +R Sbjct: 304 EIIRWQTPLAHMRRTAIADSELGGKTIRKGDKVVMWYYSGNRDDEVIDRPEEFIIDRP-- 361 Query: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF-SFKPCKETQ 472 P + FG G C+G R A M +++ +L F + E + Sbjct: 362 ------RPRQHLSFGFGIHRCVGNRLAEMQLRILWEEILTRFSRIEVMAEPE 407 >5FOI-A nrPDB Length = 408 Score = 189 bits (479), Expect = 3e-48, Method: Composition-based stats. Identities = 68/407 (16%), Positives = 138/407 (33%), Gaps = 70/407 (17%) Query: 78 QQPVLAITDPDMIKTVLVKECYSVFTNRRP----FGPVGFMKSAISIAEDEEWKRLRSLL 133 P ++ + ++ +LV +V R+P G ++ + + E RLR + Sbjct: 55 GSPTWLVSRYEHVRALLVDPRVTVDPTRQPRLSEADGDGDGFRSMLMLDPPEHTRLRRMF 114 Query: 134 SPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNI 193 F+ +++ M P I + D ++ L PV + + GV Sbjct: 115 ISAFSVRQVETMRPEIEKIVDGILDRLLALEP---PVDILTHLALPMSTQVICHLLGVPY 171 Query: 194 DSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSV 253 + F E+ + R + + + V Sbjct: 172 EDRE------------------------------FFQERSELASRPNDDRSMPALI-ELV 200 Query: 254 KRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSV 313 + + T L + + K ++ ELV +++ + AG+ET+++ Sbjct: 201 EYLDGLVRTKTAHPDTGLLGTAVTERLLK-----GEITHQELVNNAVLLLAAGHETSANQ 255 Query: 314 LSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRL 373 ++ + L HP+ +L+E Q E + V+E LR IA L Sbjct: 256 VTLSVLTLLRHPETAAELRE------------------QPELMPNAVDELLRYHSIADGL 297 Query: 374 ERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYT 433 R D+ + I G ++I + + D + F R ++ + Sbjct: 298 RRAATADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATFDIHRPARH---------HV 348 Query: 434 PFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480 FG GP C+G A + M++ L ++ + + L++ G Sbjct: 349 AFGYGPHQCLGQNLARLEMEVTLGKLFRRVPALRLAQEPDALRVRQG 395 >1CPT-A nrPDB Length = 428 Score = 188 bits (478), Expect = 4e-48, Method: Composition-based stats. Identities = 67/420 (15%), Positives = 132/420 (31%), Gaps = 56/420 (13%) Query: 68 YGKVWGFYDGQQPVLAITDPDMIK-----TVLVKECYSVFTNRRPFGPVGFMKSAISIAE 122 Y +W + P + +L + F G + S S+ + Sbjct: 48 YDPMWIATKHADVMQIGKQPGLFSNAEGSEILYDQNNEAFMRSISGGCPHVIDSLTSM-D 106 Query: 123 DEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMD 182 R L F ++++ I + V+ L G+ + D Y + Sbjct: 107 PPTHTAYRGLTLNWFQPASIRKLEENIRRIAQASVQRL--LDFDGECDFMTDCALYYPLH 164 Query: 183 VITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFP 242 V+ + GV D + L FF + + Sbjct: 165 VVMTAL-GVPED-------------DEPLMLKLTQDFFGVHEPDEQAVAAPRQ-SADEAA 209 Query: 243 REVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIF 302 R + ++ + D + L+ +S+ + D + A + Sbjct: 210 RRFHETIATFYDYFNGFTVDRRSCPKDDVMSLLANSKLDGNY-----IDDKYINAYYVAI 264 Query: 303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 362 AG++TTSS + L+ +P+ + + + +V+E Sbjct: 265 ATAGHDTTSSSSGGAIIGLSRNPEQLALAKSD------------------PALIPRLVDE 306 Query: 363 TLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKK 422 +R R D E+ G I +G +M+ + +RD + ++ P++F RF Sbjct: 307 AVRWTAPVKSFMRTALADTEVRGQNIKRGDRIMLSYPSANRDEEVFSNPDEFDITRF--- 363 Query: 423 NKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNF-SFKPCKETQIPLKLSLGG 481 P + FG G C+G A + MK+ +L S + ++ +GG Sbjct: 364 ------PNRHLGFGWGAHMCLGQHLAKLEMKIFFEELLPKLKSVELSGPPRLVATNFVGG 417 >3A1L-A nrPDB Length = 425 Score = 188 bits (477), Expect = 5e-48, Method: Composition-based stats. Identities = 67/397 (16%), Positives = 130/397 (32%), Gaps = 64/397 (16%) Query: 70 KVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGP-----VGFMKSAISIAEDE 124 + + V +++ + + V T P +++ + + Sbjct: 46 DTYYVFTYDDVVRVLSNRRLGRNARVASG-DTDTAPVPIPTEHRALRTVVENWLVFLDPP 104 Query: 125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVI 184 LRSLL+ F+ + + P IA+ L+ LR + L + F A ++ Sbjct: 105 HHTELRSLLTTEFSPSIVTGLRPRIAELASALLDRLRAQRRP----DLVEGFAAPLPILV 160 Query: 185 TSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPRE 244 S G+ ++ + + L +E Sbjct: 161 ISALLGIP---------------EEDHTWLRANAVALQEASTTRARDGRGYARAEAASQE 205 Query: 245 VTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIF 304 T + R+ V R +D V + ++ LS +V + + Sbjct: 206 FTRYFRREVDRRGGDDRDDLLTLLV------------RARDTGSPLSVDGIVGTCVHLLT 253 Query: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETL 364 AG+ETT++ L+ + L H DV +L+ E V E + Sbjct: 254 AGHETTTNFLAKAVLTLRAHRDVLDELR------------------TTPESTPAAVEELM 295 Query: 365 RLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK 424 R P + R +D+ + IP+G V+ + +RDP + +P+ R +++ Sbjct: 296 RYDPPVQAVTRWAYEDIRLGDHDIPRGSRVVALLGSANRDPARFPDPDVLDVHRAAERQ- 354 Query: 425 DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQ 461 FG G C+G A ++ L +L Sbjct: 355 --------VGFGLGIHYCLGATLARAEAEIGLRALLD 383 >6HQG-A nrPDB Length = 425 Score = 187 bits (475), Expect = 8e-48, Method: Composition-based stats. Identities = 73/442 (16%), Positives = 141/442 (31%), Gaps = 66/442 (14%) Query: 55 KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFM 114 + + + H+ G W + T+ ++ S T P F Sbjct: 47 EDPVHWGVSPHEDVGGYWSVTKYNDIMAVDTNHEVFS--------SEPTIVLPDPADDFT 98 Query: 115 KSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKD 174 + + R + P L + PII + ++ +L E + Sbjct: 99 LPMFIAMDPPKHDVQRKTVQPIVAPNHLAYLEPIIRERAGKILDDLPIGEEINWVDKVSI 158 Query: 175 VFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILE 234 ++ + D E+ +KL + + + P Sbjct: 159 ELTTMTLATL---------------FDFPWEDRRKLTFWSDVATSAPESGILGTTDPEEH 203 Query: 235 VLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLE 294 E ++ + + + D + ++ ES K + +E Sbjct: 204 ENLRRQTLFECVDYFMRLWNERVNAP------PKPDLISML------AHGESTKNMDRME 251 Query: 295 LVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQME 354 + I+ I G +TT + +S + L +PD +KL+E Sbjct: 252 YLGNLILLIVGGNDTTRNTISGSVLALHQNPDQDRKLRE------------------NPG 293 Query: 355 YLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKF 414 + +V+ET+R + R K+D E+ G I +G V + + +RD + P + Sbjct: 294 LIPAMVSETIRWQTPLAYMRRRAKRDFELGGKTIREGDKVAMWYVSGNRDEEVIDRPNDY 353 Query: 415 LPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474 ER + + FG G C+G R A + +K+ +L F P E P Sbjct: 354 WIERPRVRQ--------HLSFGFGVHRCVGNRLAELQLKIIWEEILARF---PRLEVVGP 402 Query: 475 LKLSLGGLLQP--EKPVVLKVE 494 + ++ E PVV+ Sbjct: 403 PRRVYSSFVKGYEELPVVIPTR 424 >4TX3-A nrPDB Length = 404 Score = 187 bits (475), Expect = 8e-48, Method: Composition-based stats. Identities = 60/390 (15%), Positives = 119/390 (30%), Gaps = 68/390 (17%) Query: 83 AITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKL 142 + D T + F P + + + + E RLR LL+P FT ++ Sbjct: 60 VLGDHKRFSTRRRFDRRDEIGGTGVFRPRELVGN-LMDYDPPEHTRLRHLLTPGFTQRRM 118 Query: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDP 202 + + P I + L + G P L ++F + GV D Sbjct: 119 RRLAPRIEEIVT---DRLDAMEQAGPPADLIELFADEVPGAVLCELIGVPRD-------- 167 Query: 203 FVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLE 262 FL L+ + R+ + + Sbjct: 168 ---------------------DQAMFLQLCHRHLDASLSARKRAAAGEAFARYLVAMMAR 206 Query: 263 DTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELA 322 + + F+ ++ E ++D EL + + AG + S ++ + L Sbjct: 207 ERKDPGDGFIGSIV-------AEHGDTITDEELRGVCVQLMLAGDDNVSGMIGLGVLALL 259 Query: 323 THPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMR-LERVCKKDV 381 HP+ L+ + + D V+E +R + R +DV Sbjct: 260 RHPEQIAALRGDDQSA------------------DRAVDELIRYLTVPYAPTPRTAVEDV 301 Query: 382 EINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441 + I +G V+ +RD + ++ R P + FG G + Sbjct: 302 MVADQVIKEGETVLCSLPMANRDRALLPDADRLDVTR---------TPVPHVAFGHGIHH 352 Query: 442 CIGMRFALMNMKLALIRVLQNFSFKPCKET 471 C+G + +++A + + F + Sbjct: 353 CLGAALTRLQLRIAYTALWRRFPALQLADP 382 >6HQW-A nrPDB Length = 445 Score = 186 bits (473), Expect = 1e-47, Method: Composition-based stats. Identities = 62/409 (15%), Positives = 132/409 (32%), Gaps = 63/409 (15%) Query: 68 YGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK---SAISIAEDE 124 YG W + + + P++ + ++ P + + Sbjct: 76 YGAYWNVASHKAIMHVESLPELFSSSWQYGGITIGDPPEDVDPQKLAERQLPMFIAMDRP 135 Query: 125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVI 184 + R ++P FT K+ EM I + ++ +L G+ D + Sbjct: 136 DHTGQRRTVAPAFTPAKMVEMEAEIRRRTASVLDSL----PWGERFDWVDKVSIELTTGM 191 Query: 185 TSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPRE 244 + FG L + + F E Sbjct: 192 LAILFGFPWADRR-----------------LLTFWSDWAGDVELTLARELADTRFGFLGE 234 Query: 245 VTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIF 304 + ++ ++ ++ D + +MI S E+ +S E + ++ I Sbjct: 235 MAHYFQRLWGARMQAP------PSGDLISMMIHS------EAMNHMSPQEFMGNLVLLIV 282 Query: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETL 364 G +TT + +S I++ L PD ++ L+ + + V E + Sbjct: 283 GGNDTTRNTMSGIVHALDKFPDQRELLERDA------------------SLIPNAVQECI 324 Query: 365 RLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK 424 R + R D E+ G I G V++ + +RD + P+K + +R + + Sbjct: 325 RYVTPLAHMRRTATADTELFGNQIKAGEKVILWYISANRDETVFENPDKLMVDRPNARR- 383 Query: 425 DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVL-QNFSFKPCKETQ 472 + FG G C+G R A + +++ L + + + E + Sbjct: 384 -------HLSFGHGIHRCVGARLAELQLRILLEEMHERRMRVRVAGEVE 425 >6B11-A nrPDB Length = 440 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 79/403 (19%), Positives = 144/403 (35%), Gaps = 69/403 (17%) Query: 80 PVLAITDPDMIKTVLVKECYSVFTNR----RPFGPVGFMKSAISIAEDEEWKRLRSLLSP 135 PV I+ D ++ +L S+ + P ++ + + LR P Sbjct: 88 PVWLISRQDHVRALLADPRVSIHPAKLPRLSPSDGEAEASRSLLTLDPPDHGALRGHFIP 147 Query: 136 TFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDS 195 F +++E+ P + Q L+ +L + L D + VI D Sbjct: 148 EFGLRRVRELRPSVEQIVTGLLDDLTARGDEADL--LADFALPMATQVICRLL-----DI 200 Query: 196 LNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKR 255 +D F E T++ R E+ ++L + + Sbjct: 201 PYEDRDYFQERTEQATR-------------------PAAGEEALEALLELRDYLDRLIS- 240 Query: 256 MKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLS 315 + ++ L M+ LS +++ +++ + AG+ETT+S+++ Sbjct: 241 -----GKTGRESGDGMLGSMVAQAR------GGGLSHADVLDNAVLLLAAGHETTASMVT 289 Query: 316 FIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLER 375 + L HP ++L + L V+E LR IA L R Sbjct: 290 MSVLVLLQHPTAWREL------------------TVNPGLLPGAVDELLRYLSIADGLRR 331 Query: 376 VCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPF 435 D+EI+G I G ++ A +RD ++EPE F R +++ + F Sbjct: 332 SATADIEIDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHRSARR---------HVAF 382 Query: 436 GSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS 478 G GP C+G A M +++AL VL+ L+L Sbjct: 383 GYGPHQCLGQNLARMELEVALGAVLERLPALRPTTDVAGLRLK 425 >1F4U-A nrPDB Length = 368 Score = 186 bits (472), Expect = 2e-47, Method: Composition-based stats. Identities = 75/432 (17%), Positives = 155/432 (35%), Gaps = 85/432 (19%) Query: 58 CMFDMECHKK----Y-GKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVG 112 + E KK Y G +W + + + + + L Y G + Sbjct: 2 YDWFSEMRKKDPVYYDGNIWQVFSYRYTKEVLNNFSKFSSDL--TGYHERLEDLRNGKIR 59 Query: 113 F---MKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKP 169 F + + ++ LRS+ + F+ KL+ + I + L+ Sbjct: 60 FDIPTRYTMLTSDPPLHDELRSMSADIFSPQKLQTLETFIRETTRSLLD----------S 109 Query: 170 VTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFL 229 + ++ D++ + + I ++ +E+ +K + L F Sbjct: 110 IDPRED------DIVKKLAVPLPIIVISKILGLPIEDKEKFKEWSDLVAF---------- 153 Query: 230 IPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKA 289 L E+ + + +K+ T+ + +++S Sbjct: 154 -----RLGKPGEIFELGKKYLELIGYVKDHLNSGTE-----VVSRVVNS----------N 193 Query: 290 LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT 349 LSD+E + I+ + AG ETT++++S + + ++ Q+++EE Sbjct: 194 LSDIEKLGYIILLLIAGNETTTNLISNSVIDFTRF-NLWQRIREE--------------- 237 Query: 350 VLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWT 409 + E LR P MR R K+ V++ I +G V + + +RD + + Sbjct: 238 ----NLYLKAIEEALRYSPPVMRTVRKTKERVKLGDQTIEEGEYVRVWIASANRDEEVFH 293 Query: 410 EPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCK 469 + EKF+P+R +P + FGSG C+G A + ++A+ + F Sbjct: 294 DGEKFIPDR---------NPNPHLSFGSGIHLCLGAPLARLEARIAIEEFSKRFRHIEIL 344 Query: 470 ETQIPLKLSLGG 481 +T+ L G Sbjct: 345 DTEKVPNEVLNG 356 >5FYF-A nrPDB Length = 470 Score = 185 bits (469), Expect = 4e-47, Method: Composition-based stats. Identities = 69/406 (16%), Positives = 142/406 (34%), Gaps = 59/406 (14%) Query: 68 YGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWK 127 +G W + + D+ E + + V + + Sbjct: 102 FGPFWSVTRFEDILFVDKSHDLFSA----EPQIILGDPPEGLSVEM----FIAMDPPKHD 153 Query: 128 RLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITST 187 RS + LKEM +I ++ +L + + + + Sbjct: 154 VQRSSVQGVVAPKNLKEMEGLIRSRTGDVLDSLPTDK---------------PFNWVPAV 198 Query: 188 SFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTN 247 S + L D E KL+ + S T F + R + Sbjct: 199 SKELTGRMLATLLDFPYEERHKLVEWSDRMAGAASATGGEFADENAMFDDAADMARSFSR 258 Query: 248 FLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGY 307 R KE+R ++ D + L+ ++ +K+ + +E + + I G Sbjct: 259 LWRD-----KEARRAAGEEPGFDLISLLQSNKETKDLINR----PMEFIGNLTLLIVGGN 309 Query: 308 ETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF 367 +TT + +S + + P +KL+ + E + +V+E +R Sbjct: 310 DTTRNSMSGGLVAMNEFPREFEKLKA------------------KPELIPNMVSEIIRWQ 351 Query: 368 PIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNI 427 + R+ K+DVE+ G I KG V++ + +RD + + P++F+ +R +N Sbjct: 352 TPLAYMRRIAKQDVELGGQTIKKGDRVVMWYASGNRDERKFDNPDQFIIDRKDARN---- 407 Query: 428 DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS-FKPCKETQ 472 + FG G C+G R A + +++ +L+ F + +E + Sbjct: 408 ----HMSFGYGVHRCMGNRLAELQLRILWEEILKRFDNIEVVEEPE 449 >3SN5-A nrPDB Length = 491 Score = 183 bits (465), Expect = 1e-46, Method: Composition-based stats. Identities = 95/482 (19%), Positives = 178/482 (36%), Gaps = 51/482 (10%) Query: 44 LPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDP-DMIKTVLVKECYSVF 102 +P+LG L + F +K+G V+ + V IT+P K + + + Sbjct: 22 IPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWK 81 Query: 103 TNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRR 162 F +I + + + T L + + ++ NL+R Sbjct: 82 KFHFALSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSL-------TESMMENLQR 134 Query: 163 EAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNP---QDPFVENTKKLLRFDFLDPF 219 PV+ A+ + + S + V ++ +D +T+K + LD F Sbjct: 135 IMRP--PVSSNSKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNF 192 Query: 220 FLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQ 279 VFP L+ L P + + +++ ES + + R +L+ Sbjct: 193 KQFDKVFPALVAGL--------PIHMFRTAHNAREKLAESLRHENLQKRESISELISLRM 244 Query: 280 NSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL 339 +T S DLE ++ ++A T + ++++ +P+ + EE+ L Sbjct: 245 FLNDTLS--TFDDLEKAKTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTL 302 Query: 340 ----------PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI----NG 385 N + + + LD ++ E+LRL ++ + R K+D + Sbjct: 303 ENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSASLNI-RTAKEDFTLHLEDGS 361 Query: 386 MFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID---------PYIYTPFG 436 I K ++ + +H DP+ + +P F +R+ +N Y Y PFG Sbjct: 362 YNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFG 421 Query: 437 SGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ--IPLKLSLGGL--LQPEKPVVLK 492 SG C G FA+ +K LI +L F + + PL S GL L P + K Sbjct: 422 SGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFK 481 Query: 493 VE 494 + Sbjct: 482 YK 483 >2ZBZ-A nrPDB Length = 412 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 67/449 (14%), Positives = 138/449 (30%), Gaps = 104/449 (23%) Query: 69 GKVWGFYDG-QQPVLAITDPDMIKTVL------VKECYSVF-TNRRPFGPVGFMKSAISI 120 G + + +T + + +L F F V A Sbjct: 38 GPLHRVTLYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSPAFEAVRESPQAFIG 97 Query: 121 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS 180 + E R + FT ++K M P + + + + G L Sbjct: 98 LDPPEHGTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEM---LAAGPTADL-------- 146 Query: 181 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV 240 ++ F +P + + + Sbjct: 147 ------------------------------------------VSQFALPVPSMVICRLLG 164 Query: 241 FPREVTNFLRKSVKRMKESRLEDT----QKHRVDFLQLMIDSQNSK-----------ETE 285 P F + + KR+ +S + + +L +I ++ + Sbjct: 165 VPYADHEFFQDASKRLVQSTDAQSALTARNDLAGYLDGLITQFQTEPGAGLVGALVADQL 224 Query: 286 SHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPP 345 ++ + EL++ +++ + AG+ETT+S+ S + L HP+ L+ + Sbjct: 225 ANGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADR---------- 274 Query: 346 TYDTVLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRD 404 + V E LR IA + RV D+E+ G I G V++ + +RD Sbjct: 275 --------SLVPGAVEELLRYLAIADIAGGRVATADIEVEGQLIRAGEGVIVVNSIANRD 326 Query: 405 PKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS 464 + +P+ R ++ + FG G C+G A + +++ L ++ Sbjct: 327 GTVYEDPDALDIHRSARH---------HLAFGFGVHQCLGQNLARLELEVILNALMDRVP 377 Query: 465 FKPCKETQIPLKLSLGGLLQPEKPVVLKV 493 L L G +Q + + Sbjct: 378 TLRLAVPVEQLVLRPGTTIQGVNELPVTW 406 >2XKR-A nrPDB Length = 398 Score = 183 bits (464), Expect = 2e-46, Method: Composition-based stats. Identities = 76/400 (19%), Positives = 136/400 (34%), Gaps = 69/400 (17%) Query: 100 SVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRN 159 +F+N P + +D R L++ FT ++K+ IA D L+ Sbjct: 57 ELFSNAGGIRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDKEASIAALCDTLID- 115 Query: 160 LRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPF 219 V D + + + + + + E LR+ Sbjct: 116 --------------AVCERGECDFVRDLAAPLPMAVIGDMLGVRPEQRDMFLRWSDDLVT 161 Query: 220 FLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQ 279 FLS ++ F + F + + + D + +++ S+ Sbjct: 162 FLS-----------SHVSQEDFQITMDAFAAYN-DFTRATIAARRADPTDDLVSVLVSSE 209 Query: 280 NSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL 339 E LSD ELV ++++ + G ETT LS +L + D LQ + Sbjct: 210 VDGE-----RLSDDELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRD----- 259 Query: 340 PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSY 399 L + E LR + RV D E +G + G +M+ Sbjct: 260 -------------PSLLPGAIEEMLRWTAPVKNMCRVLTADTEFHGTALCAGEKMMLLFE 306 Query: 400 ALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRV 459 + + D + EPEKF +R +P + FG G C+G + A + + L RV Sbjct: 307 SANFDEAVFCEPEKFDVQR---------NPNSHLAFGFGTHFCLGNQLARLELSLMTERV 357 Query: 460 LQNFS--FKPCKETQIPLK--------LSLGGLLQPEKPV 489 L+ ++ +PL+ S+ + P P+ Sbjct: 358 LRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFTPSPPL 397 >3P3Z-A nrPDB Length = 416 Score = 180 bits (456), Expect = 2e-45, Method: Composition-based stats. Identities = 67/362 (18%), Positives = 121/362 (33%), Gaps = 61/362 (16%) Query: 104 NRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRE 163 FM + + + +RLR L + FT ++ + P + + L+ L Sbjct: 86 GTPEGPVRDFMVDFLQSLDGADHRRLRGLATHPFTPRRITAVQPFVRSTVEQLIDKL--- 142 Query: 164 AETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSI 223 F ++ G ++ + +E L + D Sbjct: 143 --PQGDFDFVQHFPHPLPALVMCQLLGFPLEDYDTVGRLSIETNLGLALSNDQDILV--- 197 Query: 224 TVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKE 283 + + ++L ++++ K + D ++ + + Sbjct: 198 -------------KVEQGLGRMFDYLVAAIEKRKV-------EPGDDLTSDIVRAFHDG- 236 Query: 284 TESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKA 343 L D EL + AGYETT+ L+ MY+ A HPD K++E Sbjct: 237 -----VLDDYELRTLVATVLVAGYETTNHQLALAMYDFAQHPDQWMKIKE---------- 281 Query: 344 PPTYDTVLQMEYLDMVVNETLRLFPI-AMRLERVCKKDVEINGMFIPKGVVVMIPSYALH 402 E V E LR P + RV +D E+NG+ IP G V + ++ H Sbjct: 282 --------NPELAPQAVEEVLRWSPTLPVTATRVAAEDFEVNGVRIPTGTPVFMCAHVAH 333 Query: 403 RDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQN 462 RDP+ + + ++F FG GP C+G A + + A+ + Sbjct: 334 RDPRVFADADRFDIT--------VKREAPSIAFGGGPHFCLGTALARLELTEAVAALATR 385 Query: 463 FS 464 Sbjct: 386 LD 387 >3IVY-A nrPDB Length = 433 Score = 180 bits (456), Expect = 2e-45, Method: Composition-based stats. Identities = 68/425 (16%), Positives = 122/425 (28%), Gaps = 68/425 (16%) Query: 72 WGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRS 131 W D+ + F N + + + + RLR Sbjct: 71 WAITKLNDVKEISRHSDVFSS-YENGVIPRFKNDIAREDIEVQRFVMLNMDAPHHTRLRK 129 Query: 132 LLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGV 191 ++S FT + + + + + EA + + GV Sbjct: 130 IISRGFTPRAVGRLHDELQERAQ----KIAAEAAAAGSGDFVEQVSCELPLQAIAGLLGV 185 Query: 192 NIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRK 251 + E T P ++ E+ + K Sbjct: 186 PQEDRGKLFHWSNEMT-------------------GNEDPEYAHIDPKASSAELIGYAMK 226 Query: 252 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTS 311 + E + D + +I + E LSD E ++ AG ETT Sbjct: 227 MAE-------EKAKNPADDIVTQLIQADIDGEK-----LSDDEFGFFVVMLAVAGNETTR 274 Query: 312 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAM 371 + ++ M A HPD + + + + +E +R Sbjct: 275 NSITQGMMAFAEHPDQWE--------------------LYKKVRPETAADEIVRWATPVT 314 Query: 372 RLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYI 431 +R +D E++G+ I KG V++ + + D + + +P F R +P Sbjct: 315 AFQRTALRDYELSGVQIKKGQRVVMFYRSANFDEEVFQDPFTFNILR---------NPNP 365 Query: 432 YTPFGS-GPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVV 490 + FG G CIG A M + L V + K P +L G L + V Sbjct: 366 HVGFGGTGAHYCIGANLARMTINLIFNAVADHMP--DLKPISAPERLRSGWLNGIKHWQV 423 Query: 491 LKVES 495 Sbjct: 424 DYTGR 428 >6M7L-A nrPDB Length = 404 Score = 178 bits (450), Expect = 6e-45, Method: Composition-based stats. Identities = 76/402 (18%), Positives = 127/402 (31%), Gaps = 81/402 (20%) Query: 69 GKVWGFYD--GQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSA-ISIAEDEE 125 G + G D+++ VL E + F + + E Sbjct: 48 GPLVRIPLEDGSAVHWFALGYDVVREVLGSEKFDKRVIGTHFNHQEMALPGNLLQLDPPE 107 Query: 126 WKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVT-LKDVFGAYSMDVI 184 RLR +++P ++ +++ + P + D +L A TG PV L++V G + V Sbjct: 108 HTRLRRMVAPAYSVRRMQALEPRVQAIVD---DHLDTMASTGPPVEFLREVAGPMAARVA 164 Query: 185 TSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPRE 244 + L P D E + L V Sbjct: 165 C--------EFLGIPLDDRGELIR--------------------LTAHRGGKRRRVLNGH 196 Query: 245 VTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIF 304 + M+E + L ++ + +SD EL + + Sbjct: 197 AY------LAYMRELAARLRRDPGDGMLGMV-------ARDHGADISDEELAGLCAVVMN 243 Query: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETL 364 + E T S L+ L HP+ L+E + E + V E + Sbjct: 244 SSVEQTESCLAAGTLLLLEHPEQFALLRE------------------RPELGEQAVEEIV 285 Query: 365 RLFPIAMRL-ERVCKKDVEINGMFIPKGVVVMIPSYALHR-DPKYWTEPEKFLPERFSKK 422 R + L R +DVEI G I KG V A +R DP + F R Sbjct: 286 RYLSVFEGLDPRTATEDVEIGGQVIKKGEAVFCSLLAANRADPAL----DGFDITR---- 337 Query: 423 NKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS 464 + FG G +C+G A M +++A ++ F Sbjct: 338 -----KESRHVAFGHGIHHCLGAPLARMELRIAFTTLVSRFP 374 >5H1Z-A nrPDB Length = 407 Score = 178 bits (450), Expect = 7e-45, Method: Composition-based stats. Identities = 61/409 (14%), Positives = 122/409 (29%), Gaps = 64/409 (15%) Query: 65 HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDE 124 H +G W + + + PD+ + + P + Sbjct: 42 HSDFGPYWSVSSYKPIITVESLPDLYSSA----GGITLADFIENNPTDVRMPMFIAMDRP 97 Query: 125 EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVI 184 + R ++P FT ++ M I ++ +L P D + Sbjct: 98 KHTGQRRTVAPAFTPSEMVRMSDNIRMRTAEVLDSLEWNT----PFDWVDTVSVELTTQM 153 Query: 185 TSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPRE 244 + F + + F + I + LE L Sbjct: 154 LAILFDFPWEERR--------------KLTFWSDWAGDIELVKNEELRLERLRHMYECGG 199 Query: 245 VTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIF 304 L + + + D + +MI S E + +E + I+ I Sbjct: 200 YFQNLWNA---------KIGKPPTPDLISMMIHSDAMAE------MDQMEFLGNLILLIV 244 Query: 305 AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETL 364 G +TT + +S + Y L PD + KL+ + + V E + Sbjct: 245 GGNDTTRNTMSAVAYGLDLFPDQRAKLEAD------------------PSMIPNTVQEII 286 Query: 365 RLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK 424 R + R D E+ G I G + + + +RD + ++ + +R + + Sbjct: 287 RWQTPLAHMRRTATVDSELEGQQIKAGDKLALWYISANRDESVFENADRIIVDRPNARR- 345 Query: 425 DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVL-QNFSFKPCKETQ 472 + FG G C+G R A + + + L + + E + Sbjct: 346 -------HLAFGHGIHRCVGARLAELQIAVLLEEMAKRRMRVNVLGEPE 387 >6M7X-A nrPDB Length = 484 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 70/406 (17%), Positives = 163/406 (40%), Gaps = 27/406 (6%) Query: 55 KGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFM 114 + + + ++ G ++ + G ++ + P+ ++ + ++ S+ +R P Sbjct: 39 EDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKL--QQVDSLHPHRMSLEPWVAY 96 Query: 115 KS------AISIAEDEEWKRLR-SLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRE---- 163 + + + EW+ R L + ++ +P++ + L+++ Sbjct: 97 RQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQN 156 Query: 164 AETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPF---F 220 A + ++ Y+++ FG + + + N L F F Sbjct: 157 ARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMF 216 Query: 221 LSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQN 280 + ++ + P + + + + + ++++ + + + ++ Sbjct: 217 MPRSLSRWTSPKVWKEHFEAW-DCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELL---- 271 Query: 281 SKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLP 340 + LS + A S+ +TT L ++ELA +P+VQQ L++E A Sbjct: 272 -----LNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAA 326 Query: 341 NKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYA 400 + + ++ L + ETLRL+P+ + LERV D+ + IP G +V + Y+ Sbjct: 327 SISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYS 386 Query: 401 LHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMR 446 L R+P + PE++ P+R+ + + + PFG G R C+G R Sbjct: 387 LGRNPALFPRPERYNPQRWLDIRGSGRN-FYHVPFGFGMRQCLGRR 431 >5DE9-A nrPDB Length = 410 Score = 177 bits (448), Expect = 1e-44, Method: Composition-based stats. Identities = 75/425 (17%), Positives = 137/425 (32%), Gaps = 75/425 (17%) Query: 72 WGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRS 131 W L DP + ++ + F P + A+ + + RLR Sbjct: 52 WLVTRHDDVRLVTNDPRFGREAVMDRQVTRLA--PHFRP---ARGAVGFLDPPDHTRLRR 106 Query: 132 LLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKD-VFGAYSMDVITSTSFG 190 ++ FT+ ++ + D LV + R G P L + V + + VI G Sbjct: 107 SVAAAFTARGVERVRERSRGMLDELVDAMLR---AGPPADLTEAVLSPFPIAVIC-ELMG 162 Query: 191 VNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLR 250 V D + L E+ + Sbjct: 163 VPAT----------------------DRHSMHTWTQLILSSSHGAEVSERAKNEMNAYFS 200 Query: 251 KSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETT 310 + +S E D L+ ++ E V +++ G E Sbjct: 201 DLIGLRSDSAGE-------DVTSLL------GAAVGRDEITLSEAVGLAVLLQIGG-EAV 246 Query: 311 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP-- 368 ++ + + L + P++ ++L+ E E ++E LR P Sbjct: 247 TNNSGQMFHLLLSRPELAERLRSE------------------PEIRPRAIDELLRWIPHR 288 Query: 369 IAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID 428 A+ L R+ +DVEI G+ I G V + A +RDP+ + +P++ ER Sbjct: 289 NAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRIDFER---------S 339 Query: 429 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKP 488 P + FG GP C G A + +L + VL + G L++ + Sbjct: 340 PNPHVSFGFGPHYCPGGMLARLESELLVDAVLDRVPGLKLAVAPEDVPFKKGALIRGPEA 399 Query: 489 VVLKV 493 + + Sbjct: 400 LPVTW 404 >3WEC-A nrPDB Length = 419 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 73/404 (18%), Positives = 134/404 (33%), Gaps = 69/404 (17%) Query: 84 ITDPDMIKTVLVKECYSVFT-NRRPFGPVGFMKSAISI--AEDEEWKRLRSLLSPTFTSG 140 + D + S+ + PF +G A + E RLR L+S FT Sbjct: 63 LFGKDFANSTFFDHLTSMMGEDMPPFLGLGIDGDARPFMLTDPPEHTRLRGLVSDAFTRS 122 Query: 141 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ 200 M I+ VR+L + + +V + ++V++S G+ Sbjct: 123 TTTSMDDIVLSAASSAVRHLEHCTDA-----VSEVAEPFPVEVLSSIL-GIP-------- 168 Query: 201 DPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESR 260 K RF + F IP E ++ R Sbjct: 169 ------DKDRGRFSEWSNLVAGVLDINFAIPKEVADRRSAAIEESIDYFRT--------- 213 Query: 261 LEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYE 320 L + ++ + + + LS E+ A ++ AG ETTS+ + ++ Sbjct: 214 LATSGNAPEGLVRRLSEV-----SHGGDQLSVDEIAATCLLITVAGQETTSNTIGNMLIT 268 Query: 321 LATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKD 380 + H D ++++ ++++ V E LR P A R+ +D Sbjct: 269 FSRHADQFEQVRA------------------NPQFIENAVAEVLRFEPPAHEAGRIALED 310 Query: 381 VEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPR 440 E++G I KG VM+ + +R + + F R +G G Sbjct: 311 CEVSGANITKGDAVMVLLASGNR--EAVERGDTFSVTRPD---------VSSLSYGRGIH 359 Query: 441 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQ 484 +C+G A ++ L + Q + E P+ G L+ Sbjct: 360 HCLGSALANSMLQHFLRELSQRYR---SIEVAEPINYKPGMGLR 400 >4ZGX-A nrPDB Length = 489 Score = 176 bits (447), Expect = 1e-44, Method: Composition-based stats. Identities = 73/409 (17%), Positives = 161/409 (39%), Gaps = 31/409 (7%) Query: 52 SYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPV 111 H E G ++ + G ++ + P+ ++ + ++ S+ R P Sbjct: 40 HLHLEMHQTFQEL----GPIFRYNLGGPRMVCVMLPEDVEKL--QQVDSLHPCRMILEPW 93 Query: 112 GFMKS------AISIAEDEEWKRLR-SLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRE- 163 + + + EW+ R L + ++ +P++ + L+++ Sbjct: 94 VAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKV 153 Query: 164 ---AETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPF- 219 A + ++ Y+++ FG + + + N L F Sbjct: 154 LQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQ 213 Query: 220 --FLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMID 277 F+ ++ ++ P + + + + + ++++ + + +H + ++ Sbjct: 214 LMFMPRSLSRWISPKVWKEHFEAW-DCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLL 272 Query: 278 SQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDA 337 LS + A S+ +TT+ L ++ELA +PDVQQ L++E A Sbjct: 273 KAE---------LSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLA 323 Query: 338 VLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIP 397 + + ++ L + ETLRL+P+ + LERV D+ + IP G +V + Sbjct: 324 AAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVF 383 Query: 398 SYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMR 446 Y+L R+ + PE++ P+R+ + + + PFG G R C+G R Sbjct: 384 LYSLGRNAALFPRPERYNPQRWLDIRGSGRN-FHHVPFGFGMRQCLGRR 431 >1UE8-A nrPDB Length = 367 Score = 176 bits (446), Expect = 2e-44, Method: Composition-based stats. Identities = 76/403 (18%), Positives = 137/403 (33%), Gaps = 80/403 (19%) Query: 69 GKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGF---MKSAISIAEDEE 125 GKVW + + + + D + L Y+ G V F + + ++ Sbjct: 18 GKVWNLFKYEDCKMVLNDHKRFSSNL--TGYNDKLEMLRSGKVFFDIPTRYTMLTSDPPL 75 Query: 126 WKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVIT 185 LR+L + F L V + + L+ L E + + F ++ Sbjct: 76 HDELRNLTADAFNPSNLP--VDFVREVTVKLLSELDEE------FDVIESFAIPLPILVI 127 Query: 186 STSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREV 245 S G+N D + LR D F + Sbjct: 128 SKMLGINPDVKKVKDWSDLVA----LRLGRADEIFS-----------------------I 160 Query: 246 TNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA 305 + + K+ K VD + ++ LS+LE I+ + A Sbjct: 161 GRKYLELISFSKKELDSRKGKEIVDLTGKI----------ANSNLSELEKEGYFILLMIA 210 Query: 306 GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLR 365 G ETT++++ + + + + ++E + V E LR Sbjct: 211 GNETTTNLIGNAIEDFTLY-NSWDYVRE--------------------KGALKAVEEALR 249 Query: 366 LFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKD 425 P MR RV K+ V+I I +G +V + + +RD + + +P+ F+P+R Sbjct: 250 FSPPVMRTIRVTKEKVKIRDQVIDEGELVRVWIASANRDEEVFKDPDSFIPDR------- 302 Query: 426 NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPC 468 P + FGSG C+G A + ++AL + F K Sbjct: 303 --TPNPHLSFGSGIHLCLGAPLARLEARIALEEFAKKFRVKEI 343 >5L1U-A nrPDB Length = 401 Score = 175 bits (444), Expect = 4e-44, Method: Composition-based stats. Identities = 78/432 (18%), Positives = 129/432 (29%), Gaps = 80/432 (18%) Query: 66 KKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGP---------VGFMKS 116 +K G + + +T D ++T+L +N P V Sbjct: 28 QKEGPIARVGTAGEDAWLVTRYDEVRTLLADR-RLRLSNPNPQPSAKSAARAFMVALAAG 86 Query: 117 AISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVF 176 E ++RSLL P F++ +L+ M I + D L+ L A + PV L V Sbjct: 87 DDHETEPARHAQMRSLLIPRFSTRRLRLMKTRIEHHVDELLDQL---AASAPPVDLHRVL 143 Query: 177 GAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVL 236 ++ GV + RF + Sbjct: 144 SFRLPTMVVCDLLGVPLADRE--------------RFGQWARGTFDQSD----------- 178 Query: 237 NICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELV 296 N ++ V M E + D L +I E ALSD ++ Sbjct: 179 -----NEHSANTFQQVVDYMLELVARKRVEPGDDILSELI-------AEKDGALSDADIA 226 Query: 297 AQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYL 356 + GYETT + L +P + +L E+ Sbjct: 227 HLGNAVLLFGYETTIVRIDLGTLLLLRNPVQRAQLAED------------------PGLA 268 Query: 357 DMVVNETLRLFPIAMR----LERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPE 412 V E LRL + R D+ + I G VM+ A + D + + + Sbjct: 269 PAAVEEILRLGVGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPDGG 328 Query: 413 KFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ 472 F R + P + FG G R+CIG A + + R+ + + Sbjct: 329 LFDLTR--------VRPRSHLAFGHGARHCIGRTLARIELTAVFERLFRRLPDLRLAVPE 380 Query: 473 IPLKLSLGGLLQ 484 L+ + Sbjct: 381 ESLRWQEHRITG 392 >6F0B-A nrPDB Length = 395 Score = 174 bits (441), Expect = 8e-44, Method: Composition-based stats. Identities = 63/411 (15%), Positives = 140/411 (34%), Gaps = 71/411 (17%) Query: 78 QQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPV------GFMKSAISIAEDEEWKRLRS 131 P + + ++TVL +S + R F + ++ + +RLR Sbjct: 37 GTPAHVFSGYEDVRTVLQDRRFSSDSRRPNFTELTPTLQSQAAAPPFVRTDNPDHRRLRG 96 Query: 132 LLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGV 191 ++ F ++ + P I + ++ L A +D+ A+++ V ++T F + Sbjct: 97 TIAREFLPKHIELLRPAIREIVQGVLDGLAETAP------PQDMLEAFAVPVASATVFRL 150 Query: 192 NIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRK 251 + + L + ++ E R Sbjct: 151 LG----------IPAEDRALLTRCVKGVVSAV----------------GSEDEGAEVFRT 184 Query: 252 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTS 311 + + + ++ ++ ++ + K L+ E + ++ I GY+TT+ Sbjct: 185 LGEYIGGLVQDPSELPEDSLIRRLVTGPYQE-----KQLTFHETIGVILMLIVGGYDTTA 239 Query: 312 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAM 371 S +S + A P+ + E E + ++V E LR ++ Sbjct: 240 STISLSLVSYALQPEKFSVVHE------------------HPERIPLLVEELLRYHTVSQ 281 Query: 372 -RLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 430 L R+ +DVE+ G+ + G +V+ +RD + P++ +R Sbjct: 282 LGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDRP---------SV 332 Query: 431 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGG 481 + FG GP C+G A + ++ A+ V++ L Sbjct: 333 PHVGFGYGPHQCVGQALARVELQEAIPAVIRRLPGMRLACALEDLPFRHDM 383 >2RFC-A nrPDB Length = 343 Score = 173 bits (439), Expect = 1e-43, Method: Composition-based stats. Identities = 63/383 (16%), Positives = 136/383 (35%), Gaps = 80/383 (20%) Query: 83 AITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKL 142 + +K VL+ + +F++ + ++ E K R + +P F K+ Sbjct: 14 HVYKYSDVKHVLMND--KIFSSNPGNRYSNAGGISFITMDNPEHKEFRDISAPYFLPSKI 71 Query: 143 KEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDP 202 + I + + L++N+ + + + +++I+ G+ + Sbjct: 72 NDYKDFIEETSNDLIKNIDNKDI------ISEYAVRLPVNIISKIL-GIPDSDM------ 118 Query: 203 FVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLE 262 P+ ++ + + + RM LE Sbjct: 119 ----------------------------PLFKLWSDYIIGNKRDENFNYVNNRMVSRLLE 150 Query: 263 DTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELA 322 + + ++ + + ++ L+ E + ++ I G ETT++++ ++ + Sbjct: 151 IFKSDSHGIINVL-----AGSSLKNRKLTMDEKIKYIMLLIIGGNETTTNLIGNMIRVID 205 Query: 323 THPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLE-RVCKKDV 381 +PD+ ID L N++ V ETLR + L R +D Sbjct: 206 ENPDI-------IDDALKNRS--------------GFVEETLRYYSPIQFLPHRFAAEDS 244 Query: 382 EINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441 IN I KG V++ + +RD ++ EP+ F R ++ FG G Sbjct: 245 YINNKKIKKGDQVIVYLGSANRDETFFDEPDLFKIGR----------REMHLAFGIGIHM 294 Query: 442 CIGMRFALMNMKLALIRVLQNFS 464 C+G A + +AL +L +F Sbjct: 295 CLGAPLARLEASIALNDILNHFK 317 >4PWV-A nrPDB Length = 446 Score = 173 bits (437), Expect = 2e-43, Method: Composition-based stats. Identities = 70/398 (17%), Positives = 129/398 (32%), Gaps = 73/398 (18%) Query: 113 FMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTL 172 +++ + + LR++L +F+ LK +V I LV +A Sbjct: 113 AAGKMLAVTDGAMHRGLRNVLLKSFSPQALKPIVDQIRVNTTRLV----VDAARRGECDF 168 Query: 173 K-DVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIP 231 DV ++ I+ D + + + D + Sbjct: 169 AADVAEQIPLNTISDLLGVPAADREFLLKLNKSALSSEDADQSATDAWL----------- 217 Query: 232 ILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALS 291 E+ + + V + K D + ++ +S K L+ Sbjct: 218 ---------ARNEILLYFSELVAERRA-------KPTEDVISVLANSMV-----DGKPLT 256 Query: 292 DLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL 351 + +V I G ET+ + + +PD + L++ Sbjct: 257 EEVIVLNCYSLILGGDETSRLSMIDSVQTFTQYPDQWELLRDGKVT-------------- 302 Query: 352 QMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEP 411 L+ E LR AM R D+E++G I G VV + + + +RD + + +P Sbjct: 303 ----LESATEEVLRWATPAMHFGRRAVTDMELHGQVIAAGDVVTLWNNSANRDEEVFADP 358 Query: 412 EKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS--FKPCK 469 F R P + FG GP C+G + L L+ ++ F+ Sbjct: 359 YAFDLNR---------SPNKHITFGYGPHFCLGAYLGRAEVHALLDA-LRTYTTGFEITG 408 Query: 470 ETQIPLKLSLGGL------LQPEKPVVLKVESRDGTVS 501 E Q L GL +QP + + +S +G S Sbjct: 409 EPQRIHSNFLTGLSRLPVRIQPNEAAIAAYDSDNGVRS 446 >3MGX-A nrPDB Length = 415 Score = 172 bits (435), Expect = 4e-43, Method: Composition-based stats. Identities = 69/357 (19%), Positives = 127/357 (35%), Gaps = 68/357 (19%) Query: 109 GPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIA-QYGDVLVRNLRREAETG 167 P + ++E E+ ++LR L+ P + +++ + + GDVL R L G Sbjct: 97 HPDNSGGRMMVVSEHEQHRKLRKLVGPLLSRAAARKLAERVRIEVGDVLGRVLD-----G 151 Query: 168 KPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFP 227 + G + GV + + D L+ F Sbjct: 152 EVCDAATAIGPRIPAAVVCEILGVPAEDEDMLID-------------------LTNHAFG 192 Query: 228 FLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESH 287 + + + E+ + + + + ++ D + ++ Sbjct: 193 GEDELFDGMTPRQAHTEILVYFDELITARR-------KEPGDDLVSTLVT---------D 236 Query: 288 KALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTY 347 L+ +++ + G ETT ++ ++ LAT P + L++ V Sbjct: 237 DDLTIDDVLLNCDNVLIGGNETTRHAITGAVHALATVPGLLTALRDGSADV--------- 287 Query: 348 DTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKY 407 D VV E LR AM + RV DV ING +P G V+ A +RDP Sbjct: 288 ---------DTVVEEVLRWTSPAMHVLRVTTADVTINGRDLPSGTPVVAWLPAANRDPAE 338 Query: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS 464 + +P+ FLP R P + FG G +C+G A + + + L + + S Sbjct: 339 FDDPDTFLPGR---------KPNRHITFGHGMHHCLGSALARIELSVVLRVLAERVS 386 >2FR7-A nrPDB Length = 412 Score = 171 bits (434), Expect = 5e-43, Method: Composition-based stats. Identities = 74/414 (17%), Positives = 130/414 (31%), Gaps = 70/414 (16%) Query: 71 VWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLR 130 V+G + + DP + F +P+ P S I A+ R R Sbjct: 57 VYGVARYAEVYAVLNDPLTFCSSRGVGLSD-FKKEKPWRP----PSLILEADPPAHTRTR 111 Query: 131 SLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFG 190 ++LS + +K + A D + L A G + D+ AY + V + G Sbjct: 112 AVLSKVLSPATMKRLRDGFAAAADAKIDEL--LARGGNIDAIADLAEAYPLSV-FPDAMG 168 Query: 191 VNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLR 250 + + N + VF P P E+ Sbjct: 169 LKQEGRENLLPY-------------------AGLVFNAFGP----------PNELRQSAI 199 Query: 251 KSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETT 310 + + E Q+ L ++ E + AG +TT Sbjct: 200 ERSAPHQAYVAEQCQRPN---LAPGGFGACIHAFSDTGEITPEEAPLLVRSLLSAGLDTT 256 Query: 311 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA 370 + ++ +Y LA PD +L+ + E +R Sbjct: 257 VNGIAAAVYCLARFPDEFARLRAD------------------PSLARNAFEEAVRFESPV 298 Query: 371 MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 430 R +DVE+ G I +G V++ + +RDP+ W +P+++ R Sbjct: 299 QTFFRTTTRDVELAGATIGEGEKVLMFLGSANRDPRRWDDPDRYDITR---------KTS 349 Query: 431 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQ 484 + FGSG C+G A + ++ L + + E PLK L+ Sbjct: 350 GHVGFGSGVHMCVGQLVARLEGEVVLAALARKV---AAIEIAGPLKRRFNNTLR 400 >6DCD-A nrPDB Length = 424 Score = 167 bits (423), Expect = 9e-42, Method: Composition-based stats. Identities = 73/431 (16%), Positives = 140/431 (32%), Gaps = 87/431 (20%) Query: 56 GFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTN----RRPFGPV 111 + + V V+A+T + V F+N PF P+ Sbjct: 18 DPHPYFDYLRSQ-SPVLRLPQYG--VVAVTGYEEATAVYKDT--DSFSNCVALGGPFPPL 72 Query: 112 GFMKSAISIA-------------------EDEEWKRLRSLLSPTFTSGKLKEMVPIIAQY 152 F + + + E R RS+LS T +LK+ + + Sbjct: 73 PFAPNGDDVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILSRLLTPSRLKQNEEFMWRL 132 Query: 153 GDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR 212 D + E + ++ + GV D + V ++ R Sbjct: 133 ADRQLDEFLGAGE----CEFISEYAKPFATLVIADLLGVPED--DRKDFRVVLGADRMGR 186 Query: 213 FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFL 272 LD + + +L + ++ R D L Sbjct: 187 VGALDHESVGVNPLQWLDDKFS-----------------------AYIEDRRRQPRNDVL 223 Query: 273 QLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQ 332 + + + +++V + AG ETT+ +L+ M L PD+Q++L+ Sbjct: 224 TALATATYPDGSTPEV----IDVVRSATFLFAAGQETTAKLLTAAMRVLGDRPDIQRRLR 279 Query: 333 EEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGV 392 E + + E+LR+ R+ +K + G+ I G Sbjct: 280 E------------------NRSLIPNFIEESLRMDSPVKSDSRLARKRTTVGGLDIAAGT 321 Query: 393 VVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNM 452 VVM+ A +RDP+ + +P +F +R + + + F G +C G A + Sbjct: 322 VVMVLPGAANRDPRRFEDPHEFRLDRPNVRE--------HMAFARGVHSCPGGPLARVEG 373 Query: 453 KLALIRVLQNF 463 +++L R+L Sbjct: 374 RVSLERILDRM 384 >3TKT-A nrPDB Length = 450 Score = 167 bits (422), Expect = 1e-41, Method: Composition-based stats. Identities = 64/361 (17%), Positives = 120/361 (33%), Gaps = 50/361 (13%) Query: 122 EDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSM 181 + + +LR L F L + I + + + + E G + L V Y + Sbjct: 128 DAPKHPKLRRLTQDWFMPKNLARLDGEIRKIANEAIDRMLGAGEEGDFMAL--VAAPYPL 185 Query: 182 DVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVF 241 V+ D T+++ D + P P + Sbjct: 186 HVVMQILGVPPEDEPKMLFL-----TQQMFGGQDEDMNKSGLKDLP---PEQISQIVAGA 237 Query: 242 PREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSII 301 E + + + +D + + + + +SD + II Sbjct: 238 VAEFERYFAGLAAERRRNPTDD------------VATVIANAVVDGEPMSDRDTAGYYII 285 Query: 302 FIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVN 361 AG++TTS+ + LA PD+ +++ + + L +V Sbjct: 286 TASAGHDTTSASSAGAALALARDPDLFARVKADRN------------------LLPGIVE 327 Query: 362 ETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421 E +R R D E+ G I G +M+ A + DP + EP KF P R + Sbjct: 328 EAIRWTTPVQHFMRTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTRPAN 387 Query: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS-FKPCKETQIPLKLSLG 480 + + FG+G C+G+ A + M++ L +L + E + +G Sbjct: 388 R---------HLAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEPKRVNSTFVG 438 Query: 481 G 481 G Sbjct: 439 G 439 >6HQD-A nrPDB Length = 420 Score = 166 bits (420), Expect = 2e-41, Method: Composition-based stats. Identities = 65/449 (14%), Positives = 134/449 (29%), Gaps = 81/449 (18%) Query: 56 GFCMFDMECHKK----------YGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNR 105 G + ++ YG W V T+ + ++ + Sbjct: 33 GLHPYFERLRREDPVHYCKASEYGPYWSITKFSDIVAIDTNHKVFS-----SDHTNGSFV 87 Query: 106 RPFGPVGFMKSAISI-----AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL 160 + + I + + + R ++SP L I + ++ L Sbjct: 88 LDDTTLNAVDGGIYLPNFLGMDPPKHDVHRMVVSPIVAPQNLLRFEATIRERTKRVLSEL 147 Query: 161 RREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFF 220 G+ D ++ +T D L + Sbjct: 148 ----PIGEEFNWVDRVSIELTTMMLATLLDFPFDDRRK-----------------LTRWS 186 Query: 221 LSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQN 280 IT P + E + ++ + + D + ++ S Sbjct: 187 DIITTRPGYGLVDSWEQRESELMECLAYFQRLYAERQAMP------PKPDLISMLAHSPE 240 Query: 281 SKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLP 340 ++ L+ + + + I G +TT S +S +P K++ Sbjct: 241 MQD------LTPTDFLGTLALLIVGGNDTTRSSMSGSAMACHLYPQEFDKVR-------- 286 Query: 341 NKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYA 400 L V+ E +R + R +DVE G I KG V++ + Sbjct: 287 ----------NNRALLASVIPEVVRWQTPIAHMRRTALEDVEFRGKQIRKGDKVVMWYLS 336 Query: 401 LHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVL 460 +RD + P F+ +R ++ + FG G C+G R A + +K+ + Sbjct: 337 GNRDDEVIDRPMDFIADRPRARH--------HLSFGFGIHRCLGNRLAELQLKILWEEMC 388 Query: 461 QNF-SFKPCKET-QIPLKLSLGGLLQPEK 487 + + + C E ++P L G + P + Sbjct: 389 ERYSRIEVCGEPVRVPSNLVHGYIDIPVR 417 >2UUQ-A nrPDB Length = 414 Score = 163 bits (413), Expect = 2e-40, Method: Composition-based stats. Identities = 56/356 (15%), Positives = 118/356 (33%), Gaps = 61/356 (17%) Query: 119 SIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGA 178 + + R L+S FT +++ + P + ++ V L + G + ++F Sbjct: 97 VMQDPPVHTEFRKLVSRGFTPRQVETVEPTVRKFV---VERLEKLRANGGGDIVTELFKP 153 Query: 179 YSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNI 238 V+ L P++ + + FD ++ + Sbjct: 154 LPSMVVAH--------YLGVPEEDWTQ-------FDGWTQAIVAANA------------V 186 Query: 239 CVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQ 298 + + + + D + ++ + + ++ LS ++A Sbjct: 187 DGATTGALDAVGSMMAYFTGLIERRRTEPADDAISHLVAAGVGADGDTAGTLS---ILAF 243 Query: 299 SIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDM 358 + + G +T + +L M L PD ++ L ++ + + Sbjct: 244 TFTMVTGGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEG------------------IPD 285 Query: 359 VVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYW-TEPEKFLPE 417 V E LRL L R +DV I IP G V++ + +RD + + + + Sbjct: 286 AVEELLRLTSPVQGLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVT 345 Query: 418 RFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQI 473 R P F G +C+G A M ++AL +L E++I Sbjct: 346 R---------CPRNILTFSHGAHHCLGAAAARMQCRVALTELLARCPDFEVAESRI 392 >4DO1-A nrPDB Length = 410 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 69/414 (16%), Positives = 127/414 (30%), Gaps = 71/414 (17%) Query: 71 VWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLR 130 V+G + + DP + F +P+ P S I A+ R R Sbjct: 56 VYGVARYAEVHAVLNDPTTFCSSRGVGLSD-FKKEKPWRP----PSLILEADPPAHTRPR 110 Query: 131 SLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFG 190 ++LS + +K + A D V L + L + AY + V + G Sbjct: 111 AVLSKVLSPATMKTIRDGFAAAADAKVDELLQRGCIDAIADLAE---AYPLSV-FPDAMG 166 Query: 191 VNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLR 250 + + + + VF P P E+ Sbjct: 167 LKQEGREHLLPY-------------------AGLVFNAFGP----------PNELRQTAI 197 Query: 251 KSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETT 310 + + E Q+ L ++ E + AG +TT Sbjct: 198 ERSAPHQAYVNEQCQRPN---LAPGGFGACIHAFTDTGEITPDEAPLLVRSLLSAGLDTT 254 Query: 311 SSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIA 370 + + +Y LA P Q+L+ + E +R Sbjct: 255 VNGIGAAVYCLARFPGELQRLRSD------------------PTLARNAFEEAVRFESPV 296 Query: 371 MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPY 430 R ++VE+ G I +G V++ + +RDP+ W++P+ + R Sbjct: 297 QTFFRTTTREVELGGAVIGEGEKVLMFLGSANRDPRRWSDPDLYDITR---------KTS 347 Query: 431 IYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQ 484 + FGSG C+G A + ++ L + + + P+K L+ Sbjct: 348 GHVGFGSGVHMCVGQLVARLEGEVMLSALARKV---AAIDIDGPVKRRFNNTLR 398 >5LIV-A nrPDB Length = 450 Score = 162 bits (410), Expect = 3e-40, Method: Composition-based stats. Identities = 65/393 (16%), Positives = 123/393 (31%), Gaps = 63/393 (16%) Query: 83 AITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKL 142 + I T F+ R G + ++ + +E R+R + + F + Sbjct: 92 ILLRKSHITTAYRDTA--TFSTR--MFQAGILNGGLAAMQGDEHARMRRVYNMFFLPRAV 147 Query: 143 KEMVPIIAQ-YGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQD 201 + + + +V L V L + F + FG + L+ + Sbjct: 148 SQYEERFVRPISEQVVDRL----AGKPRVDLLEDFAMELPRRVIGELFGFPAEKLHETDE 203 Query: 202 PFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRL 261 + L+R V E + + V+R Sbjct: 204 RVRAMLRGLVRMH----------------DPAAVAESQRAYGETLGLITEVVER------ 241 Query: 262 EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYEL 321 + D L I E S + I GYETTS +++ ++ L Sbjct: 242 --ESRDTSDTLLGEILRTLKAEHMDTIEASRQ----IVLSLILGGYETTSWLVANTIHAL 295 Query: 322 ATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDV 381 HPD +++++ L + E +R P + + R+ ++DV Sbjct: 296 LAHPDTLARVRQD------------------PSLLPAAIEEGMRWCPSSFGVLRMVERDV 337 Query: 382 EINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441 ++ + G VV + A + D + PE + +R + FG G Sbjct: 338 RLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDRKPLPAANV--------FGGGAHF 389 Query: 442 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474 C+G A M ++ L +L F + P Sbjct: 390 CVGAPLARMEARVGLQALLARFPGLRAVPEERP 422 >5HDI-A nrPDB Length = 404 Score = 161 bits (408), Expect = 5e-40, Method: Composition-based stats. Identities = 63/356 (17%), Positives = 122/356 (34%), Gaps = 59/356 (16%) Query: 107 PFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAET 166 P+G ++ A+D R L+ + +++ M Q D L + Sbjct: 79 EMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAADRL---WVDGMQD 135 Query: 167 GKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVF 226 G + + M V+ + P + K + + + Sbjct: 136 GCIEWMGAMANRLPMMVVAEL--------IGLPDPDIAQLVK---------WGYAATQLL 178 Query: 227 PFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETES 286 L+ +++ V E++ ++ + R R + L + + S E Sbjct: 179 EGLVENDQLVAAGVALMELSGYIFEQFDR-------AAADPRDNLLGELATACASGE--- 228 Query: 287 HKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT 346 L L + AG E+T+++L ++ LAT PD+QQ+++ Sbjct: 229 ---LDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQVRA------------- 272 Query: 347 YDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPK 406 E L + ETLR P R + ++G +P +++ A +RDP Sbjct: 273 -----NPELLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPA 327 Query: 407 YWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQN 462 + P +F +R K + FG G C+G A + ++ L +L Sbjct: 328 QFEAPGEFRLDRAGGKG--------HISFGKGAHFCVGAALARLEARIVLRLLLDR 375 >6F88-A nrPDB Length = 400 Score = 161 bits (407), Expect = 7e-40, Method: Composition-based stats. Identities = 65/393 (16%), Positives = 122/393 (31%), Gaps = 63/393 (16%) Query: 83 AITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKL 142 + I T F+ R G + ++ + +E R+R + + F + Sbjct: 42 ILLRKSHITTAYRDTA--TFSTR--MFQAGILNGGLAAMQGDEHARMRRVYNMFFLPRAV 97 Query: 143 KEMVPIIAQ-YGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQD 201 + + + +V L V L + F + FG + L+ + Sbjct: 98 SQYEERFVRPISEQVVDRL----AGKPRVDLLEDFAMELPRRVIGELFGFPAEKLHETDE 153 Query: 202 PFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRL 261 + L+R V E + + V+R Sbjct: 154 RVRAMLRGLVRMH----------------DPAAVAESQRAYGETLGLITEVVER------ 191 Query: 262 EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYEL 321 + D L I E S + I GYETTS +++ ++ L Sbjct: 192 --ESRDTSDTLLGEILRTLKAEHMDTIEASRQ----IVLSLILGGYETTSWLVANTIHAL 245 Query: 322 ATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDV 381 HPD +++++ L + E +R P + R+ ++DV Sbjct: 246 LAHPDTLARVRQD------------------PSLLPAAIEEGMRWCPSNFGVLRMVERDV 287 Query: 382 EINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRN 441 ++ + G VV + A + D + PE + +R + FG G Sbjct: 288 RLDDQALSAGTVVCLAGIAGNYDETAYPSPEVYDIDRKPLPAANV--------FGGGAHF 339 Query: 442 CIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474 C+G A M ++ L +L F + P Sbjct: 340 CVGAPLARMEARVGLQALLARFPGLRAVPEERP 372 >2NZA-A nrPDB Length = 413 Score = 156 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 76/434 (17%), Positives = 138/434 (31%), Gaps = 82/434 (18%) Query: 36 LGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGF--YDGQQPVLAITDPDMIKTV 93 L + GP P L + +G +G+ W + DP + Sbjct: 22 LDLDGPEFDPVLAEL--MREGP---LTRVRLPHGEGWAWLATRYDDVKAITNDPRFGRAE 76 Query: 94 LVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYG 153 + + + F P +++ A+ + RLR ++ FT G K + P + Sbjct: 77 VTQRQITRLA--PHFKP---RPGSLAFADQPDHNRLRRAVAGAFTVGATKRLRPRAQEIL 131 Query: 154 DVLVRNLRREAETGKPVTLKD-VFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLR 212 D LV + E G P L + V + + V+ S GV Sbjct: 132 DGLVDGILAE---GPPADLVERVLEPFPIAVV-SEVMGVPAADRER-------------- 173 Query: 213 FDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFL 272 V + I+ L + +R L Sbjct: 174 ------------VHSWTRQIISTSGGAEAAERAKRGLYGWITETVRARAGSEGGDVYSML 221 Query: 273 QLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQ 332 + ET E V + G E + + ++Y L T ++ +++ Sbjct: 222 GAAVGRGEVGET---------EAVGLAGPLQIGG-EAVTHNVGQMLYLLLTRRELMARMR 271 Query: 333 EEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP--IAMRLERVCKKDVEINGMFIPK 390 E + ++E LR ++ L R+ +DVE++G I Sbjct: 272 E------------------RPGARGTALDELLRWISHRTSVGLARIALEDVEVHGTRIAA 313 Query: 391 GVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALM 450 G V + A +RDP + +P++ +R DP + +G+G C G A M Sbjct: 314 GEPVYVSYLAANRDPDVFPDPDRIDLDR---------DPNPHLAYGNGHHFCTGAVLARM 364 Query: 451 NMKLALIRVLQNFS 464 +L + +L+ Sbjct: 365 QTELLVDTLLERLP 378 >3OO3-A nrPDB Length = 384 Score = 156 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 73/402 (18%), Positives = 133/402 (33%), Gaps = 78/402 (19%) Query: 83 AITDPDMIKTVLVKECYSVFTNRRPF---GPVGFMKSAISIAEDEEWKRLRSLLSPTFTS 139 +T D ++ +L F++ RP + + + + RLR ++P +++ Sbjct: 43 LVTGHDEVRAILADH--ERFSSMRPVDDEADRALLPGILQAYDPPDHTRLRRTVAPAYSA 100 Query: 140 GKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNP 199 +++ + P I + + + + G PV A+ + + F L P Sbjct: 101 RRMERLRPRIEEIVEECLDDFE---SVGAPVDFVRHA-AWPIPAYIACEF------LGVP 150 Query: 200 QDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKES 259 +D E L ++ PR+ T V K Sbjct: 151 RDDQAE-----------------------LSRMIRESRESRLPRQRTLSGLGIVNYTKRL 187 Query: 260 RLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMY 319 + + +++ E +SD EL + + E ++ L+ + Sbjct: 188 TSGKRRDPGDGMIGVIV-------REHGAEISDEELAGLAEGNLIMAAEQMAAQLAVAVL 240 Query: 320 ELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMR-LERVCK 378 L THPD L+E + E +D E LR I RV Sbjct: 241 LLVTHPDQMALLRE------------------KPELIDSATEEVLRHASIVEAPAPRVAL 282 Query: 379 KDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSG 438 DV + G I G V+ A +R P ++F R + + FG G Sbjct: 283 ADVRMAGRDIHAGDVLTCSMLATNRAP-----GDRFDITR---------EKATHMAFGHG 328 Query: 439 PRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480 +CIG A + +++AL V+ F + L+ G Sbjct: 329 IHHCIGAPLARLQLRVALPAVVGRFPSLRLAVPEEDLRFKPG 370 >6BLD-A nrPDB Length = 419 Score = 156 bits (393), Expect = 3e-38, Method: Composition-based stats. Identities = 51/366 (13%), Positives = 103/366 (28%), Gaps = 57/366 (15%) Query: 122 EDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGA-YS 180 + +LR L+S FT +++ + I +V LR G V + Sbjct: 106 DPPRHTKLRKLVSAAFTPRQVRRIEDSIKINAKGIVDELRM---AGGGVDFVEHCAKELP 162 Query: 181 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV 240 + ++ + + D L Sbjct: 163 IRTLSDMV--------------GIPEADRERVAHAADALVSWADP-----RYLNGREPLA 203 Query: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300 E +L + + R + + D +++++ L+D ++ A + Sbjct: 204 VLFENQMYLHQVAASLAAERRD---RPGDDLFSALVNAEV-----DGDRLADADVAAFFV 255 Query: 301 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV 360 + AG +TT +S + L P + L + D + V Sbjct: 256 LLAVAGNDTTRQTISHGLKALTDFPSQKAWLLADFDTRIG-----------------TAV 298 Query: 361 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS 420 E +R M R D E+ G I G V++ + + D + PE+ R Sbjct: 299 EELVRWATPVMTFRRTAAADFELGGQLIRAGEKVVMFYASGNWDEDAFCHPERLDLSRSP 358 Query: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ-IPLKLSL 479 + ++ C+G A ++ +L + +P Sbjct: 359 NPHVGFGGGGVH--------FCLGAHLARAQLRAIFGELLVQLPDIQAGDPVYVPGNFVH 410 Query: 480 GGLLQP 485 P Sbjct: 411 AIRSMP 416 >2X9P-A nrPDB Length = 404 Score = 154 bits (389), Expect = 8e-38, Method: Composition-based stats. Identities = 68/433 (15%), Positives = 135/433 (31%), Gaps = 81/433 (18%) Query: 61 DMECHKKYGKVWGFYD-GQQPVLAITDPDMIKTVLVKE-CYSVFTNRRPFGPV---GFMK 115 + + G + +T +K +L E + F+ Sbjct: 31 LLRALQDRGPIHRVRTPAGDEAWLVTRHAELKQLLHDERIGRTHPDPPSAAQYVRSPFLD 90 Query: 116 SAISIAEDE----EWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVT 171 IS A+ E + R LL+P F++ ++ EM P + + D L+ + G P Sbjct: 91 LLISDADAESGRRQHAETRRLLTPLFSARRVLEMQPKVEEAADTLLDAFIAQ---GPPGD 147 Query: 172 LKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIP 231 L + GV T+ + Sbjct: 148 LHGELTVPFALTVLCEVIGVPPQRRAEL-----------------------TTLLAGIAK 184 Query: 232 ILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALS 291 + + ++ ++ V+ + D + + + L+ Sbjct: 185 LDDREGAVRAQDDLFGYVAGLVEHKRAEPGP-------DIISRL----------NDGELT 227 Query: 292 DLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVL 351 + + ++ +FAG ++ +S++ + LA HPD + + D Sbjct: 228 EDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPDQRAAALADPD--------------- 272 Query: 352 QMEYLDMVVNETLRLFPIAMRL--ERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWT 409 + V E LR + R +D+E G+ I G +V+ + D + +T Sbjct: 273 ---VMARAVEEVLRTARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFDERAFT 329 Query: 410 EPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCK 469 PE+F R P + FG G +CIG A + ++ ++ + Sbjct: 330 GPEEFDAAR---------TPNPHLTFGHGIWHCIGAPLARLELRTMFTKLFTRLPELRPE 380 Query: 470 ETQIPLKLSLGGL 482 L+L G L Sbjct: 381 LPVEQLRLKEGQL 393 >3BUJ-A nrPDB Length = 397 Score = 153 bits (387), Expect = 1e-37, Method: Composition-based stats. Identities = 77/385 (20%), Positives = 140/385 (36%), Gaps = 67/385 (17%) Query: 74 FYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPV-------GFMKSAISIAEDEEW 126 + G V ++ ++ VL E ++ RR + + + I ++ + Sbjct: 28 VHRGAHRVWYVSRFADVRAVLGDERFARTGIRRFWTDLVGPGLLAEIVGDIILFQDEPDH 87 Query: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186 RLR ++ P F+ L+ + P+IA D L L+ +MDV+ Sbjct: 88 GRLRGVVGPAFSPSALRRLEPVIAGTVDDL---------------LRPALARGAMDVVDE 132 Query: 187 TSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVT 246 ++ + + ++ + + R+ L+ R Sbjct: 133 LAYPLALRAVLGLLGLPAADWGAVGRWSRDVG------------RTLDRGASAEDMRRGH 180 Query: 247 NFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAG 306 + + ++ + ++ D L LM+D+ + +S E+V+ + FIF G Sbjct: 181 AAIAEFADYVERALARRRREGGEDLLALMLDAHDRG------LMSRNEIVSTVVTFIFTG 234 Query: 307 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 366 +ET +S + + L HPD L+ D L V E LR Sbjct: 235 HETVASQVGNAVLSLLAHPDQLDLLRRRPD------------------LLAQAVEECLRY 276 Query: 367 FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426 P R DVE+ G + + VV++ + A +RDP+ + P+ F ER Sbjct: 277 DPSVQSNTRQLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDFDIER-------- 328 Query: 427 IDPYIYTPFGSGPRNCIGMRFALMN 451 DP FG+G R C+G A Sbjct: 329 -DPVPSMSFGAGMRYCLGSYLARTQ 352 >5HH3-A nrPDB Length = 397 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 67/403 (16%), Positives = 125/403 (31%), Gaps = 71/403 (17%) Query: 77 GQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPT 136 G + T D I+ VL + +S ++ + E RLR +++P Sbjct: 50 GGRTAWLATGYDEIRQVLSSDDFSARLLYGGTAAGITWPGFLTQYDPPEHTRLRRMVAPA 109 Query: 137 FTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSL 196 F ++++ P + + +L G PV FG T D L Sbjct: 110 FAVRRMQKFQPQVERVVQ---DSLDAIEALGGPVDFVPRFGWSVATTATC-------DFL 159 Query: 197 NNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRM 256 P+D + + L + ++ K R Sbjct: 160 GIPRDDQADLARSLH----------------ASRTERSGKRRTAAGNKFMTYMNKMTART 203 Query: 257 KESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSF 316 + + D +++ E ++D EL + + AG + + L+ Sbjct: 204 R-------RDPGDDMFGVVV-------REYGDEITDAELTGVAAFVMGAGADQVARFLAA 249 Query: 317 IMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPI-AMRLER 375 + +A P+ L+E+ D V ++E +R R Sbjct: 250 GAWLMADDPEQFALLREKPDTV------------------PDWLDEVIRYLTTDEKTHPR 291 Query: 376 VCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEP-EKFLPERFSKKNKDNIDPYIYTP 434 V DV I I G V A +R + + P ++F R + + Sbjct: 292 VATDDVRIGDHLIKAGDTVTCSLLAANR--RNFPRPEDRFDITRVRPE---------HLA 340 Query: 435 FGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL 477 FG G +C+G A + + A+ + F E ++L Sbjct: 341 FGHGIHHCLGRSLAELVFRTAIPALAHRFPTLRLAEPHREIRL 383 >6GII-A nrPDB Length = 479 Score = 153 bits (386), Expect = 2e-37, Method: Composition-based stats. Identities = 56/405 (13%), Positives = 120/405 (29%), Gaps = 69/405 (17%) Query: 83 AITDPDMIKTVLVK-------ECYSVFTNRRPFGPVGFMKSAISIA------EDEEWKRL 129 +T D IK + F + + ++ Sbjct: 103 VVTRYDTIKQIFRDPVTFSPSNVLQSFAQPSAEVRQVLERYGYAFNRTLVNEDEPMHLER 162 Query: 130 RSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSF 189 R +L F S L E P++ + V D++ + Sbjct: 163 RRVLMEPFASEHLAEHEPMVRELVRRAVNRFIDTGRA---------------DLVDQMIW 207 Query: 190 GVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFL 249 V + ++ +K+ RF ++ F P E L + + F Sbjct: 208 EVPFTVALHFLGVDDDDREKMRRF----AIAHTVNAFGRPSPE-EQLAVAETVGQFWQFC 262 Query: 250 RKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYET 309 + +++M+ + + ++ ++D L + I A +ET Sbjct: 263 GEVLEKMRRTADGPGW----------MRYSIRQQKLYPDVVTDSYLHSMMQAIIVAAHET 312 Query: 310 TSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPI 369 T + + L H V +++ + + E LR Sbjct: 313 TVFATTNALKTLLEHETVWREICAD------------------PSLIPAAAEECLRYNGP 354 Query: 370 AMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDP 429 R ++VE+ G+ +P G +++ + + D ++ +PE F R + Sbjct: 355 VAGWRRRTTREVEVEGVRLPVGANILMVVASANHDSAHFDDPEFFDIGR--------SNA 406 Query: 430 YIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474 + FG G C+G M M++ + + + E + Sbjct: 407 SEHLNFGYGAHQCLGRNLGRMEMQIMIEELSRRLPHMRLAEQRFD 451 >5KYO-A nrPDB Length = 430 Score = 151 bits (381), Expect = 7e-37, Method: Composition-based stats. Identities = 75/427 (17%), Positives = 141/427 (33%), Gaps = 77/427 (18%) Query: 71 VWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAI----SIAEDEEW 126 +W ++G V D+ +TV+ + F+N P A + E Sbjct: 75 MWTPHNGGHWVAL--RSDLAETVMSD--FERFSNHTVLVPKETAGEAYRLIPLSLDPPEH 130 Query: 127 KRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITS 186 + RSLL+ L+ + ++ L+ R + Sbjct: 131 RPFRSLLNENLGPKPLRPIEQVVTDLAVSLIEGFRPKGRC-------------------- 170 Query: 187 TSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVT 246 N F E + +D L + P L + + + Sbjct: 171 -----------NFTHEFAEQLPVRIFMRIVD---LPVEDLPKLKHLADQYTRPDGSIPLD 216 Query: 247 NFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAG 306 + ++ + ++ K D + MI+ + + L+D+E I + G Sbjct: 217 DVTKQFREYLRPVIEARRIKPGEDMISRMINGEV-----GGRPLTDIEAENICIQVLVGG 271 Query: 307 YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL 366 +T ++L F LA +++ + + +D + E R Sbjct: 272 LDTVVNMLGFTFSHLAKDHALRRAIAAD------------------PSLIDDALLEFFRR 313 Query: 367 FPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426 FP+ R +D E G+ + G +VM P+ + D +P +F R +++ Sbjct: 314 FPVVSSA-REVLRDQEFEGVLLKAGDMVMAPTVVVAMDDARNEDPLEFRLGRKARQ---- 368 Query: 427 IDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPE 486 ++ FG G C G A M MK+ L + E PL+ S G++ Sbjct: 369 -----HSTFGKGSHTCPGAHLARMEMKVVLREWFARIP-EFRIEDDAPLRYS-NGIVGSV 421 Query: 487 KPVVLKV 493 KP VL+ Sbjct: 422 KPFVLEW 428 >5EX8-A nrPDB Length = 424 Score = 149 bits (375), Expect = 3e-36, Method: Composition-based stats. Identities = 69/392 (17%), Positives = 129/392 (32%), Gaps = 75/392 (19%) Query: 85 TDPDMIKTVLVKECYSVFTNRRPFGPVGFM---KSAISIAEDEEWKRLRSLLSPTFTSGK 141 T D ++ VL F+ R +G ++ + E RLR ++ P F+ + Sbjct: 85 TGIDEVRQVL---GSDKFSARLLYGGTAAGITWPGFLTQYDPPEHTRLRRMVVPAFSHRR 141 Query: 142 LKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQD 201 +++ P + Q +L G PV FG + + D L P+D Sbjct: 142 MQKFRPRVEQIVQ---DSLDTIESLGGPVDFVPHFGW-------AIATPATCDFLGIPRD 191 Query: 202 PFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRL 261 + L IL + T K + MK+ Sbjct: 192 DQAD-----------------------LARILLASRTDRSDKRRTAAGNKFMTYMKQHVA 228 Query: 262 EDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYEL 321 + + D ++ E+ A++D EL + + A + + +L+ + + Sbjct: 229 QSRRGSGDDLFGIV-------GRENGDAITDAELTGVAAFVMGAAADQVARLLAAGAWLM 281 Query: 322 ATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPI-AMRLERVCKKD 380 P L+E + E + ++ET+R RV +D Sbjct: 282 VEQPAQFALLRE------------------KPETVPEWLDETMRYLTTDEKTHPRVATQD 323 Query: 381 VEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPR 440 V I + G V A +R P Y + ++F R + + FG G Sbjct: 324 VRIGNQLVKAGDTVTCSLLAANR-PNYPSAEDEFDITR---------EKAEHLAFGHGIH 373 Query: 441 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQ 472 +C+G A + K+++ + F + Q Sbjct: 374 HCLGRAMAELMFKVSIPALAHRFPTLRLADPQ 405 >3OFT-A nrPDB Length = 396 Score = 148 bits (374), Expect = 4e-36, Method: Composition-based stats. Identities = 57/339 (16%), Positives = 115/339 (33%), Gaps = 65/339 (19%) Query: 122 EDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSM 181 + E K R+ + S + + P + L+ +LR ++ + Sbjct: 90 DGAEHKAFRTPVMKGLASRFVVALEPKVQAVARKLMESLRPRGSCDFVSDFAEIL---PL 146 Query: 182 DVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVF 241 ++ F ID + + +L R D + + Sbjct: 147 NI-----FLTLIDVPLEDRPRLRQLGVQLTRPD-------------------GSMTVEQL 182 Query: 242 PREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSII 301 + ++L +++ + D ++ E + + E Sbjct: 183 KQAADDYLWPFIEKRMA-------QPGDDLFSRIL-----SEPVGGRPWTVDEARRMCRN 230 Query: 302 FIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVN 361 +F G +T ++++ + LA HP+ Q+ L+E D + + Sbjct: 231 LLFGGLDTVAAMIGMVALHLARHPEDQRLLRERPD------------------LIPAAAD 272 Query: 362 ETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421 E +R +P + R DV+ +G+ I KG +V +PS + DP + PE+ +R Sbjct: 273 ELMRRYPTV-AVSRNAVADVDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDR--- 328 Query: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVL 460 + P +T G G C+G A M + + L L Sbjct: 329 ----GLAPIRHTTMGVGAHRCVGAGLARMEVIVFLREWL 363 >5HIW-A nrPDB Length = 398 Score = 147 bits (372), Expect = 8e-36, Method: Composition-based stats. Identities = 75/394 (19%), Positives = 126/394 (31%), Gaps = 65/394 (16%) Query: 82 LAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGK 141 + + D++ + E +S T G MK A+ E R+R L + + Sbjct: 41 VVLRGADVVAVLRDSETFSTRT-----YDTGIMKGALVTLGGEAHTRMRRLFNAVLSPRV 95 Query: 142 LKEMVPI-IAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ 200 + + +V L R+ L D F +TS FG+ Sbjct: 96 ISRYEEATVTPVARRVVERLVRKERA----ELFDDFAISMPMGVTSALFGLPE------- 144 Query: 201 DPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESR 260 +++ D L + V P + V + LR+ +R Sbjct: 145 -------ERIAENDALIRKMIRSVVMP--QDPVVVAEGRSAHAAMEAQLREIAEREVA-- 193 Query: 261 LEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYE 320 H D L I E + + I YETTS +L+ ++ Sbjct: 194 ------HPSDTLLGEIARAIVAEGLGGVEACE----GVVLTLILGSYETTSWMLANLLVA 243 Query: 321 LATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKD 380 L HPD +L++ Q L + E+ R A + R +++ Sbjct: 244 LLAHPDAMNQLRQ------------------QPSLLPQAIEESTRWCSSAAGIVRFVERE 285 Query: 381 VEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPR 440 I G + G ++ + A H D + + PE F R P FG G Sbjct: 286 ATIGGETLAAGTILYLSLIARHYDEEIYPRPETFDIHR---------RPVGMLNFGGGLH 336 Query: 441 NCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474 C+G A M ++ + +L+ F T P Sbjct: 337 YCVGAPLARMEARVGVSLLLERFPALRADPTVQP 370 >3B98-A nrPDB Length = 475 Score = 147 bits (370), Expect = 1e-35, Method: Composition-based stats. Identities = 89/476 (18%), Positives = 166/476 (34%), Gaps = 55/476 (11%) Query: 44 LPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFT 103 +P+LG+ L + K F +K+G ++ + + D + VL Sbjct: 27 IPWLGHALEFGKDAAKFLTRMKEKHGDIFTVRAAGLYITVLLDSNCYDAVLSDVAS---L 83 Query: 104 NRRPFGPVGFMK--SAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLV--RN 159 ++ + V + + I + + E ++ R+ + F L ++ + +L+ Sbjct: 84 DQTSYAQVLMKRIFNMILPSHNPESEKKRAEMH--FQGASLTQLSNSMQNNLRLLMTPSE 141 Query: 160 LRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPF 219 + + K L ++ + T FG NN + ++ RFD L Sbjct: 142 MGLKTSEWKKDGLFNLCYSLLFKTGYLTVFGAE----NNNSAALTQIYEEFRRFDKL--- 194 Query: 220 FLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQ 279 P L L K + R Q +++ + D Sbjct: 195 ------LPKLARTTVNKEEKQIASAAREKLWKWLTPSGLDRKPREQSWLGSYVKQLQDEG 248 Query: 280 NSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL 339 E + L + + AG ++M L THP+ + ++EEI Sbjct: 249 IDAEMQRRAML-----LQLWVTQGNAG-----PAAFWVMGYLLTHPEALRAVREEIQ--- 295 Query: 340 PNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEI-----NGMFIPKGVVV 394 K + D V+ ETLRL A+ + R +D +I + +G + Sbjct: 296 GGKHLRLEERQKNTPVFDSVLWETLRLTAAAL-ITRDVTQDKKICLSNGQEYHLRRGDRL 354 Query: 395 MI-PSYALHRDPKYWTEPEKFLPERFSKKNKDNID---------PYIYTPFGSGPRNCIG 444 + P + DP+ +PE F +RF ++ Y P+G+ C G Sbjct: 355 CVFPFISPQMDPQIHQQPEMFQFDRFLNADRTEKKDFFKNGARVKYPSVPWGTEDNLCPG 414 Query: 445 MRFALMNMKLALIRVLQNFSFKPC-KETQIPL--KLSLG-GLLQPEKPVVLKVESR 496 FA+ +K + +L F + C K +PL G G+LQP + ++ R Sbjct: 415 RHFAVHAIKELVFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAGDLEIRYRIR 470 >1WIY-A nrPDB Length = 389 Score = 146 bits (367), Expect = 3e-35, Method: Composition-based stats. Identities = 79/468 (16%), Positives = 156/468 (33%), Gaps = 80/468 (17%) Query: 34 KKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTV 93 K+L + P + + +E + + +++ + P+ I DP+ ++ Sbjct: 2 KRLSLREAWPY-----LKDLQQDPLAVLLEWGRAHPRLF-LPLPRFPLALIFDPEGVEGA 55 Query: 94 LVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYG 153 L+ E + T + + ++ + WK R L F ++ + + Sbjct: 56 LLAEGTTKATFQYRALSRLTGRGLLTDW-GKSWKEARKALKDPFLPKSVRGYREAMEEEA 114 Query: 154 DVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRF 213 R G+ L A S+ ++ FG + Sbjct: 115 WAFFGEWR-----GEERDLDHEMLALSLRLLGRALFGKPLSPSLAEH------------- 156 Query: 214 DFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQ 273 + + + ++ + L + R D Sbjct: 157 ---------------------------ALKALDRIMAQTRSPLALLDLAAEARFRKDRGA 189 Query: 274 LMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQE 333 L +++ L +++++ + AG+ET +S L++ L+ PD Q+++ Sbjct: 190 LYREAEALIVHPPLSHLPRERALSEAVTLLVAGHETVASALTWSFLLLSHRPDWQKRV-- 247 Query: 334 EIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVV 393 E E LRL+P A L R ++ + + +P+G Sbjct: 248 ----------------AESEEAALAAFQEALRLYPPAWILTRRLERPLLLGEDRLPQGTT 291 Query: 394 VMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMK 453 +++ Y R Y+ E E F PERF + Y PFG G R C+G FAL+ Sbjct: 292 LVLSPYVTQR--LYFPEGEAFQPERFLAERGT--PSGRYFPFGLGQRLCLGRDFALLEGP 347 Query: 454 LALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVS 501 + L + F P ++ + L+PE L R+G + Sbjct: 348 IVLRAFFRRFRLDPLPFPRVLAQ----VTLRPEGG--LPARPREGVRA 389 >2WIY-A nrPDB Length = 394 Score = 145 bits (366), Expect = 4e-35, Method: Composition-based stats. Identities = 57/439 (12%), Positives = 127/439 (28%), Gaps = 69/439 (15%) Query: 41 PTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYS 100 P P + + + + + + ++ + S Sbjct: 12 PWSDP------EFRNNPYPWYRRLQQDH----PVHKLEDGTYLVSRYADVSHFAKLPIMS 61 Query: 101 VFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL 160 V GP ++ LR + FT + V + L+ + Sbjct: 62 VEPGWADAGPWAVASDTALGSDPPHHTVLRRQTNKWFTPKLVDGWVRTTRELVGDLLDGV 121 Query: 161 RREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFF 220 G+ + + V + + D + + E Sbjct: 122 E----AGQVIEARRDLAVVPTHVTMARVLQLPEDDADAVMEAMFEAM------------- 164 Query: 221 LSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQN 280 + P ++ +L V M E + ++D+ Sbjct: 165 ----LMQSAEPADGDVDRAAV---AFGYLSARVAEMLE---DKRVNPGDGLADSLLDAAR 214 Query: 281 SKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLP 340 + E +++ E +A ++F G+ +++ + A P+V + + A Sbjct: 215 AGE------ITESEAIATILVFYAVGHMAIGYLIASGIELFARRPEVFTAFRNDESARA- 267 Query: 341 NKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYA 400 ++NE +R+ P + R +DVEI G+ I G + A Sbjct: 268 -----------------AIINEMVRMDPPQLSFLRFPTEDVEIGGVLIEAGSPIRFMIGA 310 Query: 401 LHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVL 460 +RDP+ + +P+ F R +++ FG GP +C G + + Sbjct: 311 ANRDPEVFDDPDVFDHTRPPAASRN-------LSFGLGPHSCAGQIISRAEATTVFAVLA 363 Query: 461 QNF-SFKPCKETQIPLKLS 478 + + + +E + Sbjct: 364 ERYERIELAEEPTVAHNDF 382 >6FYJ-A nrPDB Length = 421 Score = 142 bits (359), Expect = 3e-34, Method: Composition-based stats. Identities = 62/424 (14%), Positives = 133/424 (31%), Gaps = 59/424 (13%) Query: 70 KVWGFYDGQQPVLAITDPDMIKTVLVKECYSV-FTNRRPFGPVGFMKSAISIAEDEEWKR 128 ++ + + + + + E + F K+ + + + K Sbjct: 39 DIFETRLLGKKAICMGGKEAAEIFYDTEKFKRKDAAPNRVVQTLFGKNGVQALDGQTHKH 98 Query: 129 LRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTS 188 + + + +L+++ I + ++ V + + V L + Sbjct: 99 RKEMFMSIMSPDELEKLTDITKKQWEIAVDKWEQMDK----VILYEEAKEIMCRTAC--- 151 Query: 189 FGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNF 248 V+ + L F S L+ + Sbjct: 152 ---------QWAGVPVQENEVKRLTKNLGAMFESAAAV-----GLKHWLGRHARNYEEIW 197 Query: 249 LRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYE 308 + + + R+++ ++ + + + S + L D E A +I I Sbjct: 198 IEELIDRVRDGKVNPPENTTL--------HKFSWYRDLEGNLLDTETAAVEVINILRPIV 249 Query: 309 TTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP 368 + ++FI L +P+ ++KL+ +Y M V E R +P Sbjct: 250 AIAIFINFIALALHHYPEEKEKLKS-----------------GDKKYSQMFVQEVRRFYP 292 Query: 369 IAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNID 428 + + KKD G +G + ++ Y + DP+ W P+ F P+RF+K Sbjct: 293 FFPFVVALVKKDFTWKGYKFEEGTLTLLDLYGTNHDPEIWKNPDVFSPDRFAKWEG---S 349 Query: 429 PYIYTPFGSGP----RNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQ 484 P+ + P G G C G + MK++L + ++ LS Sbjct: 350 PFSFIPQGGGDYFMGHRCAGEWVTIEVMKVSLDYLTNRMDYE-----VPDQDLSFSMASM 404 Query: 485 PEKP 488 P P Sbjct: 405 PSIP 408 >5YHJ-A nrPDB Length = 413 Score = 141 bits (354), Expect = 1e-33, Method: Composition-based stats. Identities = 72/448 (16%), Positives = 144/448 (32%), Gaps = 64/448 (14%) Query: 47 LGNILSYHKGFCMFDMECHKKY-GKVWGFYDGQQPVLAITDPDMIKTVLVKECYSV-FTN 104 L + + + + +F K + ++ + V+ + + + ++ Sbjct: 11 LDHSVDFLREGYLFVANRRKSFQSNIFESRLLGERVICLGGEEAAEVFYDANKFTRQDAA 70 Query: 105 RRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREA 164 + F + + + E + + T I + + R + Sbjct: 71 PKRLLKTLFGEGGVQTLDGSEHTHRKQMFMSLMT-------KENIDRLLRLTYREWNQIE 123 Query: 165 ETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSIT 224 G+ + L D+ M + S GV + ++ + L F+ Sbjct: 124 RMGEEIVLYDIAQEVLMKAVCEWS-GVPL----AKEEVGKRTEEMRLLFESGTSL----- 173 Query: 225 VFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKET 284 L ++R+ VK ++ +RL + + + S Sbjct: 174 -------GPTYLQGRKARSSAEVWIRQMVKEVRSNRLLPNEH------TALYE--FSWHR 218 Query: 285 ESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAP 344 + L E+VA ++ I S + F + L PDV+++++ Sbjct: 219 DESGELLPEEVVAVEVLNILRPTVAISVYVLFTVLALHQFPDVKEQVER----------- 267 Query: 345 PTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRD 404 V + E V E R +P K D E +G P+G + ++ Y + D Sbjct: 268 ---GEVSKTE----FVQEVRRFYPFFPVAAARVKTDFEWDGYAFPEGTLTLLDLYGTNHD 320 Query: 405 PKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGP----RNCIGMRFALMNMKLALIRVL 460 WTEP++F P RF + P+ + P G G C G + +A++ + Sbjct: 321 VSIWTEPDRFDPSRFKDWKE---SPFNFIPQGGGDVDFGHRCAGEH-----VTIAILAQV 372 Query: 461 QNFSFKPCKETQIPLKLSLGGLLQPEKP 488 K T P LS + P P Sbjct: 373 IELFTKEYAYTVPPQDLSYSFVDMPSLP 400 >6G5O-A nrPDB Length = 399 Score = 136 bits (341), Expect = 3e-32, Method: Composition-based stats. Identities = 34/211 (16%), Positives = 76/211 (36%), Gaps = 32/211 (15%) Query: 252 SVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTS 311 + E ++ D ++++S+ + L+ E+ ++ G +T Sbjct: 172 LYHYIDEQIDRASENPGDDMYSVLLNSEF-----EGRKLTKEEVKGVMVLTFAGGRDTVI 226 Query: 312 SVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAM 371 + ++ + LA HP+ ++L++E E V E +R F Sbjct: 227 NAVTNSIAYLAEHPEALERLRKE------------------PEITGRAVEEMIRYFSPLT 268 Query: 372 RLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYI 431 ++ RV +D + + + + + +RD + P + + +R Sbjct: 269 QMGRVVTEDTHVCEHAVKADSRISLCWASANRDAAVFENPNEIVLDR---------KVNP 319 Query: 432 YTPFGSGPRNCIGMRFALMNMKLALIRVLQN 462 + FG NC+G A +K+ L + Q Sbjct: 320 HVGFGFSHHNCLGATHARQILKILLQTLAQK 350 >4FB2-A nrPDB Length = 398 Score = 134 bits (337), Expect = 8e-32, Method: Composition-based stats. Identities = 73/428 (17%), Positives = 141/428 (32%), Gaps = 85/428 (19%) Query: 64 CHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPV-GFMKSAISIA- 121 + YG W + I+ V+ F+N+ P + + +A Sbjct: 39 WSEAYGGHW----------VVAGYKEIQAVIQNT--KAFSNKGVTFPRYETGEFELMMAG 86 Query: 122 -EDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS 180 +D K+ R L++ F+ + Q + L+ E L + A Sbjct: 87 QDDPVHKKYRQLVAKPFSPEATDLFTEQLRQSTNDLIDARIELGEGDAATWLANEIPAR- 145 Query: 181 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV 240 +T+ G+ E+ R+ + + Sbjct: 146 ---LTAILLGLPP-----------EDGDTYRRWVW-------------------AITHVE 172 Query: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300 P E + V + E D + +I S+ E+ LS+ +L+ Sbjct: 173 NPEEGAEIFAELVAHARTLIAERRTNPGNDIMSRVIMSKIDGES-----LSEDDLIGFFT 227 Query: 301 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV 360 I + G + T+ LS + + LA +++++L + E + V Sbjct: 228 ILLLGGIDNTARFLSSVFWRLAWDIELRRRL------------------IAHPELIPNAV 269 Query: 361 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS 420 +E LR + AM + R+ ++V + + + G M+ RD + P+ + ER Sbjct: 270 DELLRFYGPAM-VGRLVTQEVTVGDITMKPGQTAMLWFPIASRDRSAFDSPDNIVIER-- 326 Query: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQN---FSFKPCKETQIPLKL 477 P + G G C+G + ++A+ L+ FS P KE + + Sbjct: 327 -------TPNRHLSLGHGIHRCLGAHLIRVEARVAITEFLKRIPEFSLDPNKECEWLMGQ 379 Query: 478 SLGGLLQP 485 G L P Sbjct: 380 VAGMLHVP 387 >3NV6-A nrPDB Length = 452 Score = 134 bits (336), Expect = 1e-31, Method: Composition-based stats. Identities = 70/411 (17%), Positives = 134/411 (32%), Gaps = 68/411 (16%) Query: 71 VWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKS---AISIAEDEEWK 127 +W + G T+ D +K V + F++ F P + + + E Sbjct: 90 IWTPFTGGHW--IATNGDTVKEVYSD--PTRFSSEVIFLPKEAGEKYQMVPTKMDPPEHT 145 Query: 128 RLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITST 187 R L K++++ + + L+ + E ++F + Sbjct: 146 PYRKALDKGLNLAKIRKVEDKVREVASSLIDSFAARGECDFAAEYAELFPVH-------- 197 Query: 188 SFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTN 247 F D E +++ R + P ++ Sbjct: 198 VFMALADLPLEDIPVLSEYARQMTRPEGNT-------------PEEMATDLEAGNNGFYA 244 Query: 248 FLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGY 307 ++ ++ D + LM++S+ + E +H L + Sbjct: 245 YVDPIIRAR-------VGGDGDDLITLMVNSEINGERIAHDKAQGLISLLLLGG-----L 292 Query: 308 ETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLF 367 +T + LSF M LA HP++ +L+ + ++ E R F Sbjct: 293 DTVVNFLSFFMIHLARHPELVAELRSDPLKLMRGA------------------EEMFRRF 334 Query: 368 PIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNI 427 P+ R+ KD E G+F+ +G ++++P+ D EP K R Sbjct: 335 PVVSEA-RMVAKDQEYKGVFLKRGDMILLPTALHGLDDAANPEPWKLDFSR--------- 384 Query: 428 DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS 478 ++ FG GP C GM A M + + L L+ KE + P+ S Sbjct: 385 RSISHSTFGGGPHRCAGMHLARMEVIVTLEEWLKRIPEFSFKEGETPIYHS 435 >2ZQJ-A nrPDB Length = 417 Score = 131 bits (330), Expect = 5e-31, Method: Composition-based stats. Identities = 73/448 (16%), Positives = 136/448 (30%), Gaps = 60/448 (13%) Query: 47 LGNILSYHKGFCMFDMECHKKYG-KVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNR 105 L N L+ K +F ++Y ++ + + +T + K + + Sbjct: 11 LDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGKNFICMTGAEAAKVFYDTDRFQRQNAL 70 Query: 106 RP-FGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREA 164 F +AI + + L T K + ++ + V + Sbjct: 71 PKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSLMTPPHQKRLAELMTEEWKAAVTRWEKAD 130 Query: 165 ETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSIT 224 E V L + V + GV + + D F + Sbjct: 131 E----VVLFEEAKEILCRVACYWA-GVPLKETEVKE--------------RADDFIDMVD 171 Query: 225 VFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKET 284 F + P ++ ++ + L+ T L M + Sbjct: 172 AFGAVGP--RHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTA---LHEMAFHTQEDGS 226 Query: 285 ESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAP 344 + ++ +EL+ + S L F L HP ++ L+ Sbjct: 227 QLDSRMAAIELINVLRPIVA-----ISYFLVFSALALHEHPKYKEWLRSGNSRER----- 276 Query: 345 PTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRD 404 +M V E R +P L + KKD N KG V++ Y + D Sbjct: 277 ------------EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHD 324 Query: 405 PKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGP----RNCIGMRFALMNMKLALIRVL 460 P+ W P++F PERF+++ ++ D P G G C G + MK +L ++ Sbjct: 325 PRLWDHPDEFRPERFAEREENLFD---MIPQGGGHAEKGHRCPGEGITIEVMKASLDFLV 381 Query: 461 QNFSFKPCKETQIPLKLSLGGLLQPEKP 488 + ++ L P P Sbjct: 382 HQIEYDVPEQ-----SLHYSLARMPSLP 404 >5D3U-A nrPDB Length = 427 Score = 131 bits (328), Expect = 9e-31, Method: Composition-based stats. Identities = 69/446 (15%), Positives = 140/446 (31%), Gaps = 70/446 (15%) Query: 26 GTHSHGLFKKLGIPG--PTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLA 83 G+H + L P P P P ++ + + + W Sbjct: 18 GSHMMTVPSPLADPSIVPDPYPVYADLAQ--RRPVHWVERLNA-----WAVLTYADCAAG 70 Query: 84 ITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK---SAISIAEDEEWKRLRSLLSPTFTSG 140 + DP + + + F + F + + + + LR + FT Sbjct: 71 LKDPRLTADRGTEVLAAKFPGQPLPPDNIFHRWTKNVVMYTDPPLHDALRRSVRAGFTRA 130 Query: 141 KLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQ 200 + ++ + LV ++ GA +D + + + + + S + Sbjct: 131 AHQHYDQVLQKVAHDLVASIPA--------------GATEIDAVPALAAELPVRSAVHAF 176 Query: 201 DPFVENTKKLL-RFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKES 259 E+ L+ R + + +F P I I ++ + + ++ M+ Sbjct: 177 GVPEEDLGFLIPRVNTIMTYFSGPKDQPVTQEI-----ILEKLTDLHTYASELLQGMRGK 231 Query: 260 RLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYE-TTSSVLSFIM 318 L DT + ++ + + + + V Q + A + TT LS Sbjct: 232 VLPDT-----------VIARLAAAQDGLTETTPEQTVHQLALVFIALFAPTTPGSLSSGT 280 Query: 319 YELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCK 378 A +P ++ + V D NE LR RV Sbjct: 281 LAFARNPRQVERFLADQACV------------------DNTANEVLRYNASNQFTWRVAA 322 Query: 379 KDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSG 438 KDVE+ G+ I G + + + +RD + P F +R + + FG G Sbjct: 323 KDVEMGGVRIEAGQTLALFLGSANRDANMFERPNDFDLDRP--------NSARHLSFGQG 374 Query: 439 PRNCIGMRFALMNMKLALIRVLQNFS 464 C+ + + +K + +L F Sbjct: 375 VHACLAAQLISLQLKWFYVALLNRFP 400 >2IAG-A nrPDB Length = 482 Score = 128 bits (321), Expect = 6e-30, Method: Composition-based stats. Identities = 86/492 (17%), Positives = 176/492 (35%), Gaps = 53/492 (10%) Query: 39 PGPTPL-----PFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTV 93 PG PL P+LG L + K F +K+G ++ G + V + DP V Sbjct: 5 PGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAV 64 Query: 94 LVKECYSVFTNRRPFGPVGFMKSAISIAEDEEW--KRLRSLLSPTFTSGKLKEM-VPIIA 150 + T F+ I + + ++ + T +L+ + + Sbjct: 65 ----VWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYT 120 Query: 151 QYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKL 210 VL+ + + L D ++ + T +G+ P+ + ++ Sbjct: 121 NLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEAL----PRTHESQAQDRV 176 Query: 211 LRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVD 270 D F + P L + V + L K + + +R K Sbjct: 177 HSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLES 236 Query: 271 FLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQK 330 +L + + S+E ++ ++ ++A +++ L +P+ Sbjct: 237 YLLHLEEMGVSEEMQARA----------LVLQLWATQGNMGPAAFWLLLFLLKNPEALAA 286 Query: 331 LQEEIDAVLPNKAPPTYDTVLQM-------EYLDMVVNETLRLFPIAMRLERVCKKDVEI 383 ++ E++++L P T LD V++E+LRL A + R D+ + Sbjct: 287 VRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRL-TAAPFITREVVVDLAM 345 Query: 384 -----NGMFIPKGVVVMI-PSYALHRDPKYWTEPEKFLPERFSKKNKDNID--------- 428 + +G +++ P + RDP+ +T+PE F RF + Sbjct: 346 PMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRL 405 Query: 429 PYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP----CKETQIPLKLSLGGLLQ 484 P+G+G +C+G +A+ ++K + VL + + + + L GL+Q Sbjct: 406 KNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQ 465 Query: 485 PEKPVVLKVESR 496 PE V ++ R Sbjct: 466 PEHDVPVRYRIR 477 >2QBO-A nrPDB Length = 421 Score = 127 bits (319), Expect = 1e-29, Method: Composition-based stats. Identities = 61/393 (15%), Positives = 125/393 (31%), Gaps = 73/393 (18%) Query: 88 DMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI---AEDEEWKRLRSLLSPTFTSGKLKE 144 +I+ E Y F++ PF P ++ I + E ++ R+L + + + Sbjct: 70 QLIREAY--EDYRHFSSECPFIPREAGEAYDFIPTSMDPPEQRQFRALANQVVGMPVVDK 127 Query: 145 MVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFV 204 + I + L+ +LR + + + F + + + + + P ++ Sbjct: 128 LENRIQELACSLIESLRPQGQCNFTEDYAEPF---PIRIFMLLA---GLPEEDIPHLKYL 181 Query: 205 ENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDT 264 + + + ++L +++ ++ D Sbjct: 182 TDQMTRPDGS---------------------MTFAEAKEALYDYLIPIIEQRRQKPGTDA 220 Query: 265 QKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATH 324 S + + + ++ E + + G +T + LSF M LA Sbjct: 221 I------------SIVANGQVNGRPITSDEAKRMCGLLLVVGLDTVVNFLSFSMEFLAKS 268 Query: 325 PDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEIN 384 P+ +Q+L E + E + E LR F + R+ D E + Sbjct: 269 PEHRQELIE------------------RPERIPAACEELLRRFSLV-ADGRILTSDYEFH 309 Query: 385 GMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIG 444 G+ + KG +++P D + P R +T FG G C+G Sbjct: 310 GVQLKKGDQILLPQMLSGLDERENACPMHVDFSR---------QKVSHTTFGHGSHLCLG 360 Query: 445 MRFALMNMKLALIRVLQNF-SFKPCKETQIPLK 476 A + + L L F QI K Sbjct: 361 QHLARREIIVTLKEWLTRIPDFSIAPGAQIQHK 393 >2IJ7-A nrPDB Length = 396 Score = 122 bits (306), Expect = 4e-28, Method: Composition-based stats. Identities = 53/337 (15%), Positives = 107/337 (31%), Gaps = 64/337 (18%) Query: 129 LRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTS 188 LR + T + + + L+ NL E G P L++ F + Sbjct: 94 LRKAVMKAITPKAP-GLEQFLRDTANSLLDNLITE---GAPADLRNDFADPLATALHCKV 149 Query: 189 FGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNF 248 G+ + + L F+ +E + + +T Sbjct: 150 LGIPQEDG--------PKLFRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTG 201 Query: 249 LRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYE 308 L + R+++ ++ +SD + F AG Sbjct: 202 LMGELSRLRKDP-------------------------AYSHVSDELFATIGVTFFGAGVI 236 Query: 309 TTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL-F 367 +T S L+ + L P ++ L E + E + V E LR+ Sbjct: 237 STGSFLTTALISLIQRPQLRNLLHE------------------KPELIPAGVEELLRINL 278 Query: 368 PIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNI 427 A L R+ D+++ + + KG +V++ + DP+++ P +R Sbjct: 279 SFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRP-------- 330 Query: 428 DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS 464 +P + FG G C G + ++ + +L+ Sbjct: 331 NPTSHLAFGRGQHFCPGSALGRRHAQIGIEALLKKMP 367 >6G71-A nrPDB Length = 405 Score = 121 bits (303), Expect = 9e-28, Method: Composition-based stats. Identities = 50/355 (14%), Positives = 103/355 (29%), Gaps = 62/355 (17%) Query: 122 EDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSM 181 +D + + R P+ G +K++ ++ + R L + G F A Sbjct: 84 DDPDHQVERRAWQPSLKPGTVKKV--WKQKFAENADRYLDAYIDAGSGSDFMQGFAA--- 138 Query: 182 DVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVF 241 + N EN + + +P Sbjct: 139 ----------PFVAENLRALIGFENASEADLQRWSQTLIDGAGNYP--DDPDVWAKAKQS 186 Query: 242 PREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSII 301 E+ L + ++ + + L ++ S + + + + + Sbjct: 187 SDEIDAALEEMIQWH-------SGRPGDSLLSYLLRSAD-------YQMPLESIRSNIKM 232 Query: 302 FIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVN 361 I G VL L + + + + + V Sbjct: 233 TIGGGLNEPRDVLGVSTLALLSSSKQLELVLRD------------------PKLWGAVFE 274 Query: 362 ETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421 E++R + R D E++G FIP+G + + + +RD W++P++F ER Sbjct: 275 ESIRWVAPIGMVPRQTVVDTELDGYFIPRGAKLGLCILSANRDRSVWSDPDRFDIER--- 331 Query: 422 KNKDNIDPYIYTPFGSGPRNCIGMRFALMNMK-LALIRVLQN---FSFKPCKETQ 472 + FG G C+G A + + L + P +E Sbjct: 332 ------GSEAHLAFGKGVHVCLGAWAARSQVADVGLPALFSRLKGLRLDPNQEAT 380 >3AWQ-A nrPDB Length = 415 Score = 121 bits (302), Expect = 9e-28, Method: Composition-based stats. Identities = 58/446 (13%), Positives = 136/446 (30%), Gaps = 62/446 (13%) Query: 51 LSYHKGFCMFDMECHKKYG-KVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRR-PF 108 LS F ++ G + + + + + Sbjct: 14 LSLLADPYRFISRQCQRLGANAFESRFLLKKTNCLKGAKAAEIFYDTTRFEREGAMPVAI 73 Query: 109 GPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGK 168 F + + + E + + + T +++ + + V R+ E Sbjct: 74 QKTLFGQGGVQGLDGETHRHRKQMFMGLMTPERVRALAQLFEAEWRRAVPGWTRKGE--- 130 Query: 169 PVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPF 228 + D + + + + + + R L F + Sbjct: 131 -IVFYDELHEPLTRAVCAWA------------GVPLPDDEAGNRAGELRALFDAAG---- 173 Query: 229 LIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHK 288 L + R V + ++ ++ ++ + + + H Sbjct: 174 -SASPRHLWSRLARRRVDAWAKRIIEGIRAGSIGSGSGTAA--------YAIAWHRDRHD 224 Query: 289 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYD 348 L + A ++ + + ++F+ + L T ++ L ++ D Sbjct: 225 DLLSPHVAAVELVNVLRPTVAIAVYITFVAHALQTCSGIRAALVQQPD------------ 272 Query: 349 TVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYW 408 Y ++ V E R +P + +D E GM P+G V++ Y + D W Sbjct: 273 ------YAELFVQEVRRFYPFFPAVVARASQDFEWEGMAFPEGRQVVLDLYGSNHDAATW 326 Query: 409 TEPEKFLPERFSKKNKDNIDPYIYTPFGSGP----RNCIGMRFALMNMKLALIRVLQNFS 464 +P++F PERF ++D+ + + P G G C G L MK+A ++ Sbjct: 327 ADPQEFRPERFRAWDEDSFN---FIPQGGGDHYLGHRCPGEWIVLAIMKVAAHLLVNAMR 383 Query: 465 FKPCKE------TQIPLKLSLGGLLQ 484 + + ++P G +++ Sbjct: 384 YDVPDQDLSIDFARLPALPKSGFVMR 409 >5OMS-A nrPDB Length = 409 Score = 119 bits (299), Expect = 2e-27, Method: Composition-based stats. Identities = 57/414 (13%), Positives = 117/414 (28%), Gaps = 57/414 (13%) Query: 50 ILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFG 109 + + + + G + ++ + V P G Sbjct: 19 MTQLERNPYEVYERLRAEAPLAFVPVLGSY---VASTAEVCRE--VATSPDFEAVITPAG 73 Query: 110 PVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEM-VPIIAQYGDVLVRNLRREAETGK 168 F AI + LRS++ P ++ ++ + + Sbjct: 74 GRTFGHPAIIGVNGDIHADLRSMVEPALQPAEVDRWIDDLVRPIARRYLERFENDGHA-- 131 Query: 169 PVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPF 228 A + ++ S G + D E KL R F + F Sbjct: 132 ------ELVAQYCEPVSVRSLGDLLGLQEVDSDKLREWFAKLNR-SFTNAAVDENGEFAN 184 Query: 229 LIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHK 288 E E+ + + + E + H + D +T + Sbjct: 185 PEGFAEG---DQAKAEIRAVVDPLIDKWIEHPDDSAISHW------LHDGMPPGQTRDRE 235 Query: 289 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYD 348 + V G+ ++ + L + P+ +++ ++ Sbjct: 236 YIYPTIYVYLLGAMQEPGH-----GMASTLVGLFSRPEQLEEVVDD-------------- 276 Query: 349 TVLQMEYLDMVVNETLRLFPIAMRLE-RVCKKDVEINGMFIPKGVVVMIPSYALHRDPKY 407 + + E LR R+ K V I G+ +P G VM+ + + D Sbjct: 277 ----PTLIPRAIAEGLRWTSPIWSATARISTKPVTIAGVDLPAGTPVMLSYGSANHDTGK 332 Query: 408 WTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQ 461 + P ++ R P + FG+G C G+ FA M++AL + + Sbjct: 333 YEAPSQYDLHRP---------PLPHLAFGAGNHACAGIYFANHVMRIALEELFE 377 >5M0P-A nrPDB Length = 428 Score = 119 bits (298), Expect = 3e-27, Method: Composition-based stats. Identities = 76/462 (16%), Positives = 144/462 (31%), Gaps = 64/462 (13%) Query: 47 LGNILSYHKGFCMFDMECHKKYG-KVWGFY-DGQQPVLAITDPDMIKTVLVKECYSVFTN 104 L N L K ++ + V+ G +P + +T + + + Sbjct: 16 LDNTLKVLKQGYLYTTNQRNRLNTSVFQTKALGGKPFVVVTGKEGAEMFYNNDVVQREGM 75 Query: 105 RRP-FGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRE 163 K AI + ++ ++L T G L VR L R Sbjct: 76 LPKRIVNTLAGKGAIHTVDGKKHVDRKALFMSLMTEGNLN------------YVRELTRT 123 Query: 164 --AETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFL 221 + + D Y ++ T G + P + +E + L Sbjct: 124 LWHANTQRMESMDEVNIYRESIVLLTKVGTRWAGVQAPPED-IERIATDMDIMIDSFRAL 182 Query: 222 SITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNS 281 + + + E RK E H D+L +DS+ Sbjct: 183 GGAFKGYKASKEARRRVEDWLEEQIIETRKGNIHPPEGTALYEFAHWEDYLGNPMDSRTC 242 Query: 282 KETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPN 341 ++L+ I + +SF ++ + +P ++K++ E D Sbjct: 243 A----------IDLMNTFRPLIA-----INRFVSFGLHAMNENPITREKIKSEPD----- 282 Query: 342 KAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYAL 401 Y E R +P L K D++ G+ IP GV + + Y Sbjct: 283 -------------YAYKFAQEVRRYYPFVPFLPGKAKVDIDFQGVTIPAGVGLALDVYGT 329 Query: 402 HRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGP----RNCIGMRFALMNMKLALI 457 D W +P +F PERF + P+ P G G C G ++ M+ + Sbjct: 330 THDESLWDDPNEFRPERFETWDG---SPFDLIPQGGGDYWTNHRCAGEWITVIIMEETMK 386 Query: 458 RVLQNFSFK-PCKETQIPLKL-----SLGGLLQPEKPVVLKV 493 + ++ P ++ ++ L G +++ + VV + Sbjct: 387 YFAEKITYDVPEQDLEVDLNSIPGYVKSGFVIKNVREVVDRT 428 >4C9K-A nrPDB Length = 421 Score = 119 bits (297), Expect = 4e-27, Method: Composition-based stats. Identities = 63/455 (13%), Positives = 142/455 (31%), Gaps = 78/455 (17%) Query: 53 YHKGFCMFDMECHKKYGK--VWGFYDGQQPVLAITDPDMIKTVLVKECY---SVFTNRRP 107 +GF + VW + G + + L+ E Y F++R Sbjct: 36 LEQGFHEAWKRVQQPDTPPLVWTPFTGGHWI-------ATRGTLIDEIYRSPERFSSRVI 88 Query: 108 FGPVGFMKSAISI---AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREA 164 + P ++ + + E R + +++++ I V + A Sbjct: 89 WVPREAGEAYDMVPTKLDPPEHTPYRKAIDKGLNLAEIRKLEDQIRTIA---VEIIEGFA 145 Query: 165 ETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSIT 224 + G FG ++ + + L +T Sbjct: 146 DRGH------------------CEFGSEFSTVFPVRVFLALAGLPVEDATKLGLLANEMT 187 Query: 225 VFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKET 284 P + ++ + ++ + + D + +++ + Sbjct: 188 RPSGNTPEEQGRSLEAANKGFFEYVAPIIAARR-------GGSGTDLITRILNVEI---- 236 Query: 285 ESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAP 344 K + D + + + G +T + L F+M L+ HP+ +++ E Sbjct: 237 -DGKPMPDDRALGLVSLLLLGGLDTVVNFLGFMMIYLSRHPETVAEMRREPLK------- 288 Query: 345 PTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRD 404 L V E R F + R D+E +G + +G ++++P+ D Sbjct: 289 -----------LQRGVEELFRRFAVV-SDARYVVSDMEFHGTMLKEGDLILLPTALHGLD 336 Query: 405 PKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS 464 ++ +P R ++ F GP C GM A + + + L L Sbjct: 337 DRHHDDPMTVDLSR---------RDVTHSTFAQGPHRCAGMHLARLEVTVMLQEWLARIP 387 Query: 465 FKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGT 499 K+ +P+ S G++ + + L+ E + + Sbjct: 388 EFRLKDRAVPIYHS--GIVAAVENIPLEWEPQRVS 420 >2RCM-A nrPDB Length = 495 Score = 105 bits (261), Expect = 6e-23, Method: Composition-based stats. Identities = 85/487 (17%), Positives = 151/487 (31%), Gaps = 74/487 (15%) Query: 37 GIPGPTPLPFLGNILS-----YHKGFCMFDMECHKKYGK-VWGFYD--------GQQPVL 82 IPG LP +G I Y +G F +KY V+ Q V Sbjct: 29 NIPGNYGLPIVGPIKDRWDYFYDQGAEEFFKSRIRKYNSTVYRVNMPPGAFIAENPQVVA 88 Query: 83 AITDPDM-----IKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTF 137 + + V K+ + T G + + E L Sbjct: 89 LLDGKSFPVLFDVDKVEKKDLLT-GTYMPSTELTGGYRILSYLDPSEPKHEKLKNLLFFL 147 Query: 138 TSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLN 197 + P L +L +E + + + +G N Sbjct: 148 LKSSRNRIFPEFQATYSELFDSLEKELSLKGKADFGGSSDGTAFNFLARAFYGTNPADTK 207 Query: 198 NPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMK 257 D TK +L L P P +I + + P V + ++ + Sbjct: 208 LKADAPGLITKWVLF--NLHPLLSI--GLPRVIEEPLIHTFSLPPALVKSDYQRLYEFFL 263 Query: 258 ESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFI 317 ES E +++++ +S E +FA + ++ Sbjct: 264 ESAGE-----------ILVEADKLG-------ISREEATHN---LLFA-----TCFNTWG 297 Query: 318 MYELATHPD-----------VQQKLQEEIDAVL-PNKAPPTYDTVLQMEYLDMVVNETLR 365 ++ P+ V +L EEI +V+ N T + +ME VV E LR Sbjct: 298 GMKIL-FPNMVKRIGRAGHQVHNRLAEEIRSVIKSNGGELTMGAIEKMELTKSVVYECLR 356 Query: 366 LFPIAMRLERVCKKDVEINGM----FIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSK 421 P KKD+ I + G ++ RDPK + ++F+PERF Sbjct: 357 FEPPVTAQYGRAKKDLVIESHDAAFKVKAGEMLYGYQPLATRDPKIFDRADEFVPERFVG 416 Query: 422 KNKDNIDPYIYTPFG-------SGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIP 474 + + + ++ G G + C G F ++ +L +I + + + + P Sbjct: 417 EEGEKLLRHVLWSNGPETETPTVGNKQCAGKDFVVLVARLFVIEIFRRYDSFDIEVGTSP 476 Query: 475 LKLSLGG 481 L S+ Sbjct: 477 LGSSVNF 483 >3DBM-A nrPDB Length = 473 Score = 86.0 bits (211), Expect = 3e-17, Method: Composition-based stats. Identities = 77/478 (16%), Positives = 143/478 (29%), Gaps = 69/478 (14%) Query: 38 IPGPTPLPFLGNI---LSY-----HKGFCMFDMECHKKYGKVWGFYDGQQP-------VL 82 IPG +PF I L Y + F K V+ P V+ Sbjct: 11 IPGSYGIPFFQPIKDRLEYFYGTGGRDEY-FRSRMQKYQSTVFRANMPPGPFVSSNPKVI 69 Query: 83 AITDPDMIK---TVLVKECYSVFTNRRPFGPVGFMKSAISIA---EDEEWKRLRSLLSPT 136 + D V E +FT + + +L++LL Sbjct: 70 VLLDAKSFPILFDVSKVEKKDLFTGTYMPSTKLTGGYRVLSYLDPSEPRHAQLKNLLFFM 129 Query: 137 FTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSL 196 + + + P L L E DV + + F N + Sbjct: 130 LKNSSNRVI-PQFETTYTELFEGLEAELAKNGKAAFNDVGEQAAFRFLGRAYFNSNPEET 188 Query: 197 NNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVF-PREVTNFLRKSVKR 255 L P + P+L + F + N L + Sbjct: 189 --KLGTSAPTLISSWVLFNLAPTLDLGLPWFLQEPLLHTFRLPAFLIKSTYNKLYDYFQS 246 Query: 256 MKESRLEDTQK---HRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSS 312 + +E +K + + + ++ + K L + Sbjct: 247 VATPVMEQAEKLGVPKDEAVHNILFAVCFNTFGGVKILFP-------------------N 287 Query: 313 VLSFIMYELATHPDVQQKLQEEIDAVLPN--KAPPTYDTVLQMEYLDMVVNETLRLFPIA 370 L +I ++ +L EEI + + T + + QM VV E+LR+ P Sbjct: 288 TLKWIGLA---GENLHTQLAEEIRGAIKSYGDGNVTLEAIEQMPLTKSVVYESLRIEPPV 344 Query: 371 MRLERVCKKDVEINGM----FIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDN 426 K + I + KG ++ +DPK + PE+++P+RF + Sbjct: 345 PPQYGKAKSNFTIESHDATFEVKKGEMLFGYQPFATKDPKVFDRPEEYVPDRFVGDGEAL 404 Query: 427 IDPYIYTPFGSGP---------RNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPL 475 + Y + +GP + C G F ++ +L +I + + + + + PL Sbjct: 405 LK---YVWWSNGPETESPTVENKQCAGKDFVVLITRLFVIELFRRYDSFEIELGESPL 459 >2YJN-B nrPDB Length = 381 Score = 66.7 bits (161), Expect = 2e-11, Method: Composition-based stats. Identities = 25/122 (20%), Positives = 49/122 (40%), Gaps = 18/122 (14%) Query: 303 IFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNE 362 +FAG E T++ + + ++ P + +++ ++ A V E Sbjct: 220 LFAGAEMTANTVVDAVLAVSAEPGLAERIADDPAAA------------------QRTVAE 261 Query: 363 TLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKK 422 LRL P R +V + I +G V++ A +RDP+ + EP++ +R Sbjct: 262 VLRLHPALHLERRTATAEVRLGEHVIGEGEEVVVVVAAANRDPEVFAEPDRLDVDRPDAD 321 Query: 423 NK 424 Sbjct: 322 RA 323 >1NG6-A nrPDB Length = 148 Score = 31.6 bits (70), Expect = 0.80, Method: Composition-based stats. Identities = 19/115 (16%), Positives = 43/115 (37%), Gaps = 8/115 (6%) Query: 198 NPQDPFVENTKKLLRFDFLDPFFLSITVFPFLI-PILEVLNICVFPREVTNFLRKSVKRM 256 + + ++ K ++ D + V L +++ + E L + +K+ Sbjct: 2 SLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDSLTEDEELTVLSRELKQR 61 Query: 257 KESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTS 311 K+S E + +R+D + + + E + LS+ EL ET + Sbjct: 62 KDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRTIV-------NETIA 109 >4YXC-B nrPDB Length = 227 Score = 30.9 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 14/48 (29%), Positives = 25/48 (52%), Gaps = 3/48 (6%) Query: 352 QMEYLDMVVNETLRLF-PIAMRLERVCKK--DVEINGMFIPKGVVVMI 396 ++ M + E LRL + L+ + + D+ ING I +G VV++ Sbjct: 157 ELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVV 204 >3BT7-A nrPDB Length = 369 Score = 30.5 bits (67), Expect = 1.8, Method: Composition-based stats. Identities = 18/130 (13%), Positives = 38/130 (29%), Gaps = 26/130 (20%) Query: 227 PFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETES 286 PF + EV V + R D ++ D Q Sbjct: 31 PFSDLVPEVFRSPVSHYRMRAEFR-------------IWHDGDDLYHIIFDQQTKSRIRV 77 Query: 287 HKALSDLELVAQSIIFIFAGY-------------ETTSSVLSFIMYELATHPDVQQKLQE 333 + EL+ Q + + AG + +++ + + L H + + ++ Sbjct: 78 DSFPAASELINQLMTAMIAGVRNNPVLRHKLFQIDYLTTLSNQAVVSLLYHKKLDDEWRQ 137 Query: 334 EIDAVLPNKA 343 E +A+ Sbjct: 138 EAEALRDALR 147 >4M2J-A nrPDB Length = 406 Score = 30.5 bits (67), Expect = 1.9, Method: Composition-based stats. Identities = 6/47 (12%), Positives = 15/47 (31%) Query: 327 VQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRL 373 V ++ D ++ +A + + E +R P + Sbjct: 285 VAERAVRHADELIGARAAEARHNLAHLTGWMAAHEELVRWTPPEGGV 331 >4YXB-D nrPDB Length = 80 Score = 29.7 bits (65), Expect = 3.2, Method: Composition-based stats. Identities = 14/48 (29%), Positives = 25/48 (52%), Gaps = 3/48 (6%) Query: 352 QMEYLDMVVNETLRLF-PIAMRLERVCKK--DVEINGMFIPKGVVVMI 396 ++ M + E LRL + L+ + + D+ ING I +G VV++ Sbjct: 10 ELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVV 57 >4DJD-D nrPDB Length = 323 Score = 29.7 bits (65), Expect = 3.2, Method: Composition-based stats. Identities = 9/36 (25%), Positives = 20/36 (55%), Gaps = 1/36 (2%) Query: 309 TTSSVLSFIMY-ELATHPDVQQKLQEEIDAVLPNKA 343 T +++L + L HP+ +++E ID ++ + A Sbjct: 287 TATALLQAGAHILLMRHPEAVARVKENIDQLMVSNA 322 >3I7T-A nrPDB Length = 149 Score = 29.7 bits (65), Expect = 3.2, Method: Composition-based stats. Identities = 11/81 (13%), Positives = 29/81 (35%), Gaps = 3/81 (3%) Query: 91 KTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFT-SGKLKEMVPII 149 + L + + + +++ I + + W+ + + + F + MV + Sbjct: 46 RDALRR--IEIALGQAGATLADVVRTRIYVTDISRWREVGEVHAQAFGKIRPVTSMVEVT 103 Query: 150 AQYGDVLVRNLRREAETGKPV 170 A L+ + +A G V Sbjct: 104 ALIAPGLLVEIEADAYVGSAV 124 >3RFT-A nrPDB Length = 267 Score = 28.9 bits (63), Expect = 5.0, Method: Composition-based stats. Identities = 8/53 (15%), Positives = 17/53 (32%), Gaps = 11/53 (20%) Query: 398 SYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALM 450 + + Y+ + E+ P+ ++ + G C G A M Sbjct: 108 FASSNHTIGYYPQTERLGPDVPARPDGL-----------YGVSKCFGENLARM 149 >2XSA-A nrPDB Length = 447 Score = 28.6 bits (62), Expect = 7.5, Method: Composition-based stats. Identities = 19/99 (19%), Positives = 28/99 (28%), Gaps = 18/99 (18%) Query: 358 MVVNETLRLFPIAMRLERVCKKDVE------INGMF-----IPKGVVVM------IPSYA 400 V E LR P+ D+ + G + G + A Sbjct: 206 AAVGEVLRRRPVIWDNFHANDYDIRRVFAGPLGGRSRDILPLVAGWITNPNNEAEANFPA 265 Query: 401 LHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGP 439 +H Y +P+ + PER P FG G Sbjct: 266 IHTTGAYLADPD-YAPERAIAAAVAAWQPRFRLAFGDGA 303 >3RP9-A nrPDB Length = 458 Score = 28.6 bits (62), Expect = 7.6, Method: Composition-based stats. Identities = 10/57 (17%), Positives = 18/57 (31%), Gaps = 3/57 (5%) Query: 322 ATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQME---YLDMVVNETLRLFPIAMRLER 375 HP ++ E++ K ++ + M+ V E R P R Sbjct: 395 LAHPFFKEVRIAEVETNATEKVRLPFNDWMNMDEPQLRYAFVKEIQRYHPEIQLPRR 451 >5EUV-A nrPDB Length = 731 Score = 28.2 bits (61), Expect = 9.0, Method: Composition-based stats. Identities = 19/92 (20%), Positives = 30/92 (32%), Gaps = 20/92 (21%) Query: 369 IAMRLERVCKKDVE-INGMFIPKGVVVMIPSYALHRDPKYWTEPE----KFLPERFSKKN 423 + R + E + G I K V ++ Y H P +PE + + N Sbjct: 418 PLINRPRTALRPTEEVTG--IKKPVPYLVTEYNGHMFPTKAQDPELRQMEHVIRHLEVLN 475 Query: 424 KDNIDP-------------YIYTPFGSGPRNC 442 + DP + FG+G R C Sbjct: 476 AAHGDPAISGCIGWCMFDYNTHKDFGAGDRIC 507 >4M60-A nrPDB Length = 418 Score = 28.2 bits (61), Expect = 9.3, Method: Composition-based stats. Identities = 9/52 (17%), Positives = 19/52 (36%) Query: 304 FAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEY 355 A E T+ +L L P+V ++L+ + +++ E Sbjct: 350 LATEEATADLLRETALALVDDPEVARRLRRIQAEMAQEGGTRRAADLIEAEL 401 >6FRK-r nrPDB Length = 605 Score = 28.2 bits (61), Expect = 9.7, Method: Composition-based stats. Identities = 8/17 (47%), Positives = 12/17 (70%) Query: 402 HRDPKYWTEPEKFLPER 418 + DPK +PE++LP R Sbjct: 565 NYDPKVTPDPERWLPMR 581 >5M73-D nrPDB Length = 158 Score = 28.2 bits (61), Expect = 9.7, Method: Composition-based stats. Identities = 8/17 (47%), Positives = 12/17 (70%) Query: 402 HRDPKYWTEPEKFLPER 418 + DPK +PE++LP R Sbjct: 55 NYDPKVTPDPERWLPMR 71 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.313 0.128 0.340 Lambda K H 0.267 0.0393 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,089,619 Number of Sequences: 36641 Number of extensions: 770950 Number of successful extensions: 3069 Number of sequences better than 10.0: 187 Number of HSP's better than 10.0 without gapping: 304 Number of HSP's successfully gapped in prelim test: 57 Number of HSP's that attempted gapping in prelim test: 1869 Number of HSP's gapped (non-prelim): 434 length of query: 503 length of database: 10,336,785 effective HSP length: 101 effective length of query: 402 effective length of database: 6,636,044 effective search space: 2667689688 effective search space used: 2667689688 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.5 bits) S2: 61 (28.2 bits)