BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P08133 (673 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1M9I-A nrPDB 1375 0.0 1AVC-A nrPDB 1302 0.0 1YII-A nrPDB 378 e-105 1SAV-A nrPDB 372 e-103 2IE7-A nrPDB 370 e-103 2ZOC-A nrPDB 348 4e-96 2ZHI-A nrPDB 346 2e-95 1I4A-A nrPDB 342 3e-94 1AII-A nrPDB 327 1e-89 1W3W-A nrPDB 319 2e-87 5N7D-A nrPDB 293 1e-79 4X9P-A nrPDB 290 2e-78 6B3I-A nrPDB 285 5e-77 1DM5-A nrPDB 279 2e-75 1AIN-A nrPDB 273 2e-73 1HM6-A nrPDB 269 3e-72 4MDV-A nrPDB 223 2e-58 1YCN-A nrPDB 176 3e-44 3BRX-A nrPDB 155 7e-38 1DK5-A nrPDB 148 9e-36 1BO9-A nrPDB 66 4e-11 3CHK-A nrPDB 65 1e-10 4EVF-A nrPDB 50 4e-06 2IIC-A nrPDB 37 0.030 3J8C-K nrPDB 31 2.0 6FEC-6 nrPDB 31 2.1 5FL3-A nrPDB 30 2.7 4AQ4-A nrPDB 29 5.3 4FXY-P nrPDB 29 8.3 2O36-A nrPDB 28 9.6 >1M9I-A nrPDB Length = 672 Score = 1375 bits (3559), Expect = 0.0, Method: Compositional matrix adjust. Identities = 670/672 (99%), Positives = 671/672 (99%) Query: 2 AKPAQGAKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQS 61 AKPAQGAKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQS Sbjct: 1 AKPAQGAKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQS 60 Query: 62 YKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILAS 121 YKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILAS Sbjct: 61 YKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILAS 120 Query: 122 RTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDV 181 RTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDV Sbjct: 121 RTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDV 180 Query: 182 QDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKL 241 QDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKL Sbjct: 181 QDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKL 240 Query: 242 MLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSL 301 MLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSL Sbjct: 241 MLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSL 300 Query: 302 YSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPAN 361 YSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKG VRPAN Sbjct: 301 YSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGDVRPAN 360 Query: 362 DFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEI 421 DFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEI Sbjct: 361 DFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEI 420 Query: 422 SGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDY 481 SGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDY Sbjct: 421 SGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDY 480 Query: 482 HKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDKT 541 HKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDKT Sbjct: 481 HKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDKT 540 Query: 542 SLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNKP 601 SLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNKP Sbjct: 541 SLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNKP 600 Query: 602 LFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGDF 661 LFFADKLYKSMKGAGTD+KTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGDF Sbjct: 601 LFFADKLYKSMKGAGTDDKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGDF 660 Query: 662 LKALLALCGGED 673 LKALLALCGGED Sbjct: 661 LKALLALCGGED 672 >1AVC-A nrPDB Length = 673 Score = 1302 bits (3370), Expect = 0.0, Method: Compositional matrix adjust. Identities = 632/673 (93%), Positives = 655/673 (97%) Query: 1 MAKPAQGAKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQ 60 MAK AQGAKYRGSI DFP F+P+QDAE LY AMKGFGSDKEAI+++ITSRSN+QRQE+CQ Sbjct: 1 MAKIAQGAKYRGSIRDFPDFNPSQDAETLYNAMKGFGSDKEAIINLITSRSNKQRQEICQ 60 Query: 61 SYKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILA 120 +YKSLYGKDLIADLKYELTGKFERLIVGLMRPPAY DAKEIKDAISGIGTDEKCLIEILA Sbjct: 61 NYKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYADAKEIKDAISGIGTDEKCLIEILA 120 Query: 121 SRTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQD 180 SRTNEQ+HQLVAAYKDAYERDLEADI GDTSGHF+KMLVVLLQGTREEDDVVSEDLVQQD Sbjct: 121 SRTNEQIHQLVAAYKDAYERDLEADITGDTSGHFRKMLVVLLQGTREEDDVVSEDLVQQD 180 Query: 181 VQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEK 240 VQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEK Sbjct: 181 VQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEK 240 Query: 241 LMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKS 300 LMLAVVKCIRST EYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKS Sbjct: 241 LMLAVVKCIRSTAEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKS 300 Query: 301 LYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPA 360 LYSMIKNDTSGEYKKTLLKL GGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPA Sbjct: 301 LYSMIKNDTSGEYKKTLLKLCGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPA 360 Query: 361 NDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSE 420 DFNPDADAKALRKAMKGLGTDEDTIIDIITHRSN QRQQIRQTFKSHFGRDLM DLKSE Sbjct: 361 GDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNAQRQQIRQTFKSHFGRDLMADLKSE 420 Query: 421 ISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKED 480 +SGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEI+AIN+AYKED Sbjct: 421 LSGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIQAINKAYKED 480 Query: 481 YHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDK 540 YHK+LEDALSSDTSGHF+RILISLATG+REEGGE+ ++AREDAQVAAEILEIADT SGDK Sbjct: 481 YHKTLEDALSSDTSGHFKRILISLATGNREEGGEDRERAREDAQVAAEILEIADTTSGDK 540 Query: 541 TSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNK 600 +SLETRFM ILCTRSYP LRRVFQEF+KMTNYDVEHTIKKEMSGDVRD FVAIVQSVKNK Sbjct: 541 SSLETRFMMILCTRSYPDLRRVFQEFVKMTNYDVEHTIKKEMSGDVRDVFVAIVQSVKNK 600 Query: 601 PLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGD 660 PLFFADKLYKSMKGAGT+EKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSG Sbjct: 601 PLFFADKLYKSMKGAGTEEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGH 660 Query: 661 FLKALLALCGGED 673 FLKALLA+CGGED Sbjct: 661 FLKALLAICGGED 673 >1YII-A nrPDB Length = 320 Score = 378 bits (970), Expect = e-105, Method: Compositional matrix adjust. Identities = 190/320 (59%), Positives = 233/320 (72%), Gaps = 1/320 (0%) Query: 8 AKY-RGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLY 66 AKY RG++ F FD DAEAL AMKG G+D+E IL I+TSR+N QRQE+ ++K+L+ Sbjct: 1 AKYTRGTVTAFSPFDARADAEALRKAMKGMGTDEETILKILTSRNNAQRQEIASAFKTLF 60 Query: 67 GKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQ 126 G+DL+ DLK ELTGKFE L+V LMRP DA +K AI G GT+EK L EILASRT + Sbjct: 61 GRDLVDDLKSELTGKFETLMVSLMRPARIFDAHALKHAIKGAGTNEKVLTEILASRTPAE 120 Query: 127 MHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYE 186 + + Y YE +LE I G+TSGHFQ++LVVLLQ R+ D V E LV++D Q L+ Sbjct: 121 VQNIKQVYMQEYEANLEDKITGETSGHFQRLLVVLLQANRDPDGRVDEALVEKDAQVLFR 180 Query: 187 AGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVV 246 AGELKWGTDE FI ILG RS HLR VFD+Y+ +G IE +I E SGD EKL+LAVV Sbjct: 181 AGELKWGTDEETFITILGTRSVSHLRRVFDKYMTISGFQIEETIDRETSGDLEKLLLAVV 240 Query: 247 KCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIK 306 KCIRS P YFAE L+ +MKG GT D+TLIR+MVSRSE+D+LDIR FR + KSLY MI+ Sbjct: 241 KCIRSVPAYFAETLYYSMKGAGTDDDTLIRVMVSRSEIDLLDIRHEFRKNFAKSLYQMIQ 300 Query: 307 NDTSGEYKKTLLKLSGGDDD 326 DTSG+Y+K LL L GGDD+ Sbjct: 301 KDTSGDYRKALLLLCGGDDE 320 Score = 313 bits (803), Expect = 1e-85, Method: Compositional matrix adjust. Identities = 161/322 (50%), Positives = 228/322 (70%), Gaps = 9/322 (2%) Query: 354 KGTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDL 413 +GTV + F+ ADA+ALRKAMKG+GTDE+TI+ I+T R+N QRQ+I FK+ FGRDL Sbjct: 5 RGTVTAFSPFDARADAEALRKAMKGMGTDEETILKILTSRNNAQRQEIASAFKTLFGRDL 64 Query: 414 MTDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAI 473 + DLKSE++G L++ LM P +DA LK A++GAGT+EK L EILA+RT AE++ I Sbjct: 65 VDDLKSELTGKFETLMVSLMRPARIFDAHALKHAIKGAGTNEKVLTEILASRTPAEVQNI 124 Query: 474 NEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQA--REDAQVAAEILE 531 + Y ++Y +LED ++ +TSGHF+R+L+ L +R+ G +D+A +DAQV + Sbjct: 125 KQVYMQEYEANLEDKITGETSGHFQRLLVVLLQANRDPDG-RVDEALVEKDAQV---LFR 180 Query: 532 IADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFV 591 + G E F+TIL TRS HLRRVF +++ ++ + +E TI +E SGD+ + Sbjct: 181 AGELKWGTD---EETFITILGTRSVSHLRRVFDKYMTISGFQIEETIDRETSGDLEKLLL 237 Query: 592 AIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQ 651 A+V+ +++ P +FA+ LY SMKGAGTD+ TL R+MVSRSEIDLL+IR EF + + KSL+Q Sbjct: 238 AVVKCIRSVPAYFAETLYYSMKGAGTDDDTLIRVMVSRSEIDLLDIRHEFRKNFAKSLYQ 297 Query: 652 AIEGDTSGDFLKALLALCGGED 673 I+ DTSGD+ KALL LCGG+D Sbjct: 298 MIQKDTSGDYRKALLLLCGGDD 319 Score = 119 bits (297), Expect = 5e-27, Method: Compositional matrix adjust. Identities = 87/326 (26%), Positives = 161/326 (49%), Gaps = 44/326 (13%) Query: 193 GTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRST 252 GTDE + IL +R+ + + + G+ + ++ EL+G FE LM+++++ R Sbjct: 31 GTDEETILKILTSRNNAQRQEIASAFKTLFGRDLVDDLKSELTGKFETLMVSLMRPARI- 89 Query: 253 PEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGE 312 + A L A+KG GT + L I+ SR+ ++ +I++++ +YE +L I +TSG Sbjct: 90 --FDAHALKHAIKGAGTNEKVLTEILASRTPAEVQNIKQVYMQEYEANLEDKITGETSGH 147 Query: 313 YKKTLLKLSGGDDDAAGQ----FFPEAAQVAYQMWELSAVARVELKGTVRPANDFNPDAD 368 +++ L+ L + D G+ + AQV ++ EL Sbjct: 148 FQRLLVVLLQANRDPDGRVDEALVEKDAQVLFRAGELK---------------------- 185 Query: 369 AKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARL 428 GTDE+T I I+ RS +++ + + G + + E SGDL +L Sbjct: 186 ----------WGTDEETFITILGTRSVSHLRRVFDKYMTISGFQIEETIDRETSGDLEKL 235 Query: 429 ILGLM----MPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKS 484 +L ++ PA++ A+ L +M+GAGTD+ LI ++ +R+ ++ I +++++ KS Sbjct: 236 LLAVVKCIRSVPAYF-AETLYYSMKGAGTDDDTLIRVMVSRSEIDLLDIRHEFRKNFAKS 294 Query: 485 LEDALSSDTSGHFRRILISLATGHRE 510 L + DTSG +R+ L+ L G E Sbjct: 295 LYQMIQKDTSGDYRKALLLLCGGDDE 320 >1SAV-A nrPDB Length = 320 Score = 372 bits (956), Expect = e-103, Method: Compositional matrix adjust. Identities = 182/315 (57%), Positives = 234/315 (74%) Query: 11 RGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDL 70 RG++ DFPGFD DAE L AMKG G+D+E+IL ++TSRSN QRQE+ ++K+L+G+DL Sbjct: 6 RGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTLFGRDL 65 Query: 71 IADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQL 130 + DLK ELTGKFE+LIV LM+P DA E+K A+ G GT+EK L EI+ASRT E++ + Sbjct: 66 LDDLKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTNEKVLTEIIASRTPEELRAI 125 Query: 131 VAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGEL 190 Y++ Y LE D++GDTSG++Q+MLVVLLQ R+ D + E V+QD Q L++AGEL Sbjct: 126 KQVYEEEYGSSLEDDVVGDTSGYYQRMLVVLLQANRDPDAGIDEAQVEQDAQALFQAGEL 185 Query: 191 KWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIR 250 KWGTDE +FI I G RS HLR VFD+Y+ +G IE +I E SG+ E+L+LAVVK IR Sbjct: 186 KWGTDEEKFITIFGTRSVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIR 245 Query: 251 STPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTS 310 S P Y AE L+ AMKG GT D+TLIR+MVSRSE+D+ +IR+ FR + SLYSMIK DTS Sbjct: 246 SIPAYLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTS 305 Query: 311 GEYKKTLLKLSGGDD 325 G+YKK LL L G DD Sbjct: 306 GDYKKALLLLCGEDD 320 Score = 309 bits (792), Expect = 2e-84, Method: Compositional matrix adjust. Identities = 156/322 (48%), Positives = 226/322 (70%), Gaps = 7/322 (2%) Query: 353 LKGTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRD 412 L+GTV F+ ADA+ LRKAMKGLGTDE++I+ ++T RSN QRQ+I FK+ FGRD Sbjct: 5 LRGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTLFGRD 64 Query: 413 LMTDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRA 472 L+ DLKSE++G +LI+ LM P YDA +LK A++GAGT+EK L EI+A+RT E+RA Sbjct: 65 LLDDLKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTNEKVLTEIIASRTPEELRA 124 Query: 473 INEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHRE-EGGENLDQAREDAQVAAEILE 531 I + Y+E+Y SLED + DTSG+++R+L+ L +R+ + G + Q +DAQ + + Sbjct: 125 IKQVYEEEYGSSLEDDVVGDTSGYYQRMLVVLLQANRDPDAGIDEAQVEQDAQA---LFQ 181 Query: 532 IADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFV 591 + G E +F+TI TRS HLR+VF +++ ++ + +E TI +E SG++ + Sbjct: 182 AGELKWGTD---EEKFITIFGTRSVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLL 238 Query: 592 AIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQ 651 A+V+S+++ P + A+ LY +MKGAGTD+ TL R+MVSRSEIDL NIR+EF + + SL+ Sbjct: 239 AVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYS 298 Query: 652 AIEGDTSGDFLKALLALCGGED 673 I+GDTSGD+ KALL LCG +D Sbjct: 299 MIKGDTSGDYKKALLLLCGEDD 320 Score = 110 bits (276), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 88/318 (27%), Positives = 159/318 (50%), Gaps = 38/318 (11%) Query: 193 GTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRST 252 GTDE + +L +RS + + + G+ + ++ EL+G FEKL++A++K R Sbjct: 32 GTDEESILTLLTSRSNAQRQEISAAFKTLFGRDLLDDLKSELTGKFEKLIVALMKPSRL- 90 Query: 253 PEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGE 312 Y A L A+KG GT + L I+ SR+ ++ I++++ +Y SL + DTSG Sbjct: 91 --YDAYELKHALKGAGTNEKVLTEIIASRTPEELRAIKQVYEEEYGSSLEDDVVGDTSGY 148 Query: 313 YKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPANDFNPDADAKAL 372 Y++ L+ L + D P+A ++ + DA+AL Sbjct: 149 YQRMLVVLLQANRD------PDAG-----------------------IDEAQVEQDAQAL 179 Query: 373 RKAMK-GLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARLILG 431 +A + GTDE+ I I RS +++ + + G + + E SG+L +L+L Sbjct: 180 FQAGELKWGTDEEKFITIFGTRSVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLA 239 Query: 432 LMMP----PAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKSLED 487 ++ PA Y A+ L AM+GAGTD+ LI ++ +R+ ++ I + +++++ SL Sbjct: 240 VVKSIRSIPA-YLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYS 298 Query: 488 ALSSDTSGHFRRILISLA 505 + DTSG +++ L+ L Sbjct: 299 MIKGDTSGDYKKALLLLC 316 >2IE7-A nrPDB Length = 318 Score = 370 bits (951), Expect = e-103, Method: Compositional matrix adjust. Identities = 178/316 (56%), Positives = 237/316 (75%) Query: 11 RGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDL 70 RG++ DF GFD DAE L AMKG G+D+++IL+++T+RSN QRQ++ + +K+L+G+DL Sbjct: 3 RGTVTDFSGFDGRADAEVLRKAMKGLGTDEDSILNLLTARSNAQRQQIAEEFKTLFGRDL 62 Query: 71 IADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQL 130 + D+K ELTGKFE+LIV LM+P DA E+K A+ G GTDEK L EI+ASRT E++ + Sbjct: 63 VNDMKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTDEKVLTEIIASRTPEELRAI 122 Query: 131 VAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGEL 190 AY++ Y +LE D++GDTSG++Q+MLVVLLQ R+ D + + V+ D Q L++AGEL Sbjct: 123 KQAYEEEYGSNLEDDVVGDTSGYYQRMLVVLLQANRDPDTAIDDAQVELDAQALFQAGEL 182 Query: 191 KWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIR 250 KWGTDE +FI ILG RS HLR VFD+Y+ +G IE +I E SG+ E L+LAVVK IR Sbjct: 183 KWGTDEEKFITILGTRSVSHLRRVFDKYMTISGFQIEETIDRETSGNLENLLLAVVKSIR 242 Query: 251 STPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTS 310 S P Y AE L+ AMKG GT D+TLIR++VSRSE+D+ +IR+ FR + SLYSMIK DTS Sbjct: 243 SIPAYLAETLYYAMKGAGTDDHTLIRVIVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTS 302 Query: 311 GEYKKTLLKLSGGDDD 326 G+YKK LL L GG+DD Sbjct: 303 GDYKKALLLLCGGEDD 318 Score = 323 bits (829), Expect = 1e-88, Method: Compositional matrix adjust. Identities = 163/324 (50%), Positives = 233/324 (71%), Gaps = 11/324 (3%) Query: 353 LKGTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRD 412 L+GTV + F+ ADA+ LRKAMKGLGTDED+I++++T RSN QRQQI + FK+ FGRD Sbjct: 2 LRGTVTDFSGFDGRADAEVLRKAMKGLGTDEDSILNLLTARSNAQRQQIAEEFKTLFGRD 61 Query: 413 LMTDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRA 472 L+ D+KSE++G +LI+ LM P YDA +LK A++GAGTDEK L EI+A+RT E+RA Sbjct: 62 LVNDMKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTDEKVLTEIIASRTPEELRA 121 Query: 473 INEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQV---AAEI 529 I +AY+E+Y +LED + DTSG+++R+L+ L +R+ D A +DAQV A + Sbjct: 122 IKQAYEEEYGSNLEDDVVGDTSGYYQRMLVVLLQANRDP-----DTAIDDAQVELDAQAL 176 Query: 530 LEIADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDA 589 + + G E +F+TIL TRS HLRRVF +++ ++ + +E TI +E SG++ + Sbjct: 177 FQAGELKWGTD---EEKFITILGTRSVSHLRRVFDKYMTISGFQIEETIDRETSGNLENL 233 Query: 590 FVAIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSL 649 +A+V+S+++ P + A+ LY +MKGAGTD+ TL R++VSRSEIDL NIR+EF + + SL Sbjct: 234 LLAVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVIVSRSEIDLFNIRKEFRKNFATSL 293 Query: 650 HQAIEGDTSGDFLKALLALCGGED 673 + I+GDTSGD+ KALL LCGGED Sbjct: 294 YSMIKGDTSGDYKKALLLLCGGED 317 >2ZOC-A nrPDB Length = 319 Score = 348 bits (893), Expect = 4e-96, Method: Compositional matrix adjust. Identities = 171/314 (54%), Positives = 228/314 (72%) Query: 12 GSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLI 71 G++ GF+ +DA+ L AMKG G+D++AI+ ++ R+ QRQE+ +YKS G+DLI Sbjct: 6 GTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLI 65 Query: 72 ADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLV 131 DLK EL+G FE++IVG+M P D +E++ A+ G GTDE CLIEILASRT E++ ++ Sbjct: 66 DDLKSELSGNFEQVIVGMMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRTPEEIRRIS 125 Query: 132 AAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELK 191 Y+ Y R LE DI DTS FQ++LV L G R+E + + + LV+QD QDLYEAGE K Sbjct: 126 QTYQQQYGRSLEDDIRSDTSFMFQRVLVSLSAGGRDEGNYLDDALVRQDAQDLYEAGEKK 185 Query: 192 WGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRS 251 WGTDE +F+ +L +R++ HL VFDEY + + K IE SI+ E SG FE +LA+VKC+R+ Sbjct: 186 WGTDEVKFLTVLCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAIVKCMRN 245 Query: 252 TPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSG 311 YFAE+L+K+MKGLGT DNTLIR+MVSR+E+DMLDIR F+ Y KSLYS IK DTSG Sbjct: 246 KSAYFAEKLYKSMKGLGTDDNTLIRVMVSRAEIDMLDIRAHFKRLYGKSLYSFIKGDTSG 305 Query: 312 EYKKTLLKLSGGDD 325 +Y+K LL L GGDD Sbjct: 306 DYRKVLLVLCGGDD 319 Score = 333 bits (855), Expect = 1e-91, Method: Compositional matrix adjust. Identities = 168/321 (52%), Positives = 231/321 (71%), Gaps = 9/321 (2%) Query: 355 GTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLM 414 GTV+ A+ FN DA+ LRKAMKGLGTDED II ++ +R+ QRQ+IR +KS GRDL+ Sbjct: 6 GTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLI 65 Query: 415 TDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAIN 474 DLKSE+SG+ ++I+G+M P YD ++L++AM+GAGTDE LIEILA+RT EIR I+ Sbjct: 66 DDLKSELSGNFEQVIVGMMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRTPEEIRRIS 125 Query: 475 EAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQA--REDAQVAAEILEI 532 + Y++ Y +SLED + SDTS F+R+L+SL+ G R+E G LD A R+DAQ ++ E Sbjct: 126 QTYQQQYGRSLEDDIRSDTSFMFQRVLVSLSAGGRDE-GNYLDDALVRQDAQ---DLYEA 181 Query: 533 ADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVA 592 + G E +F+T+LC+R+ HL VF E+ +++ D+E +IK E SG DA +A Sbjct: 182 GEKKWGTD---EVKFLTVLCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLA 238 Query: 593 IVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQA 652 IV+ ++NK +FA+KLYKSMKG GTD+ TL R+MVSR+EID+L+IR F Y KSL+ Sbjct: 239 IVKCMRNKSAYFAEKLYKSMKGLGTDDNTLIRVMVSRAEIDMLDIRAHFKRLYGKSLYSF 298 Query: 653 IEGDTSGDFLKALLALCGGED 673 I+GDTSGD+ K LL LCGG+D Sbjct: 299 IKGDTSGDYRKVLLVLCGGDD 319 Score = 120 bits (301), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 97/333 (29%), Positives = 163/333 (48%), Gaps = 37/333 (11%) Query: 179 QDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDF 238 +D Q L +A + GTDE I +L R+ + + Y T G+ + ++ ELSG+F Sbjct: 18 EDAQTLRKAMK-GLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSGNF 76 Query: 239 EKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYE 298 E++ +V + T Y + L +AMKG GT + LI I+ SR+ ++ I + ++ +Y Sbjct: 77 EQV---IVGMMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRTPEEIRRISQTYQQQYG 133 Query: 299 KSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVR 358 +SL I++DTS +++ L+ LS G D G + +A VR Sbjct: 134 RSLEDDIRSDTSFMFQRVLVSLSAGGRD-EGNYLDDA--------------------LVR 172 Query: 359 PANDFNPDADAKALRKA-MKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDL 417 DA+ L +A K GTDE + ++ R+ + +K +D+ + Sbjct: 173 Q--------DAQDLYEAGEKKWGTDEVKFLTVLCSRNRNHLLHVFDEYKRISQKDIEQSI 224 Query: 418 KSEISGDLARLILGL---MMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAIN 474 KSE SG +L + M + Y A++L K+M+G GTD+ LI ++ +R ++ I Sbjct: 225 KSETSGSFEDALLAIVKCMRNKSAYFAEKLYKSMKGLGTDDNTLIRVMVSRAEIDMLDIR 284 Query: 475 EAYKEDYHKSLEDALSSDTSGHFRRILISLATG 507 +K Y KSL + DTSG +R++L+ L G Sbjct: 285 AHFKRLYGKSLYSFIKGDTSGDYRKVLLVLCGG 317 >2ZHI-A nrPDB Length = 322 Score = 346 bits (887), Expect = 2e-95, Method: Compositional matrix adjust. Identities = 168/314 (53%), Positives = 227/314 (72%) Query: 12 GSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLI 71 G++ GF+ +DA+ L AMKG G+D++AI+ ++ R+ QRQE+ +YKS G+DL+ Sbjct: 9 GTVKAASGFNATEDAQVLRKAMKGLGTDEDAIIGVLACRNTAQRQEIRTAYKSTIGRDLL 68 Query: 72 ADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLV 131 DLK EL+ FE++I+G+M P D +E++ A+ G GTDE CLIEILASR E++ ++ Sbjct: 69 EDLKSELSSNFEQVILGMMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRNPEEIRRIN 128 Query: 132 AAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELK 191 Y+ Y R LE DI DTS FQ++LV L G R+E + + + LV+QD QDLYEAGE + Sbjct: 129 QTYQQQYGRSLEEDICSDTSFMFQRVLVSLTAGGRDEGNYLDDALVKQDAQDLYEAGEKR 188 Query: 192 WGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRS 251 WGTDE +F+ IL +R++ HL VFDEY + + K IE SI+ E SG FE +LA+VKC+R+ Sbjct: 189 WGTDEVKFLSILCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAIVKCMRN 248 Query: 252 TPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSG 311 P YFAERL+K+MKGLGT D+TLIR+MVSR+E+DMLDIR F+ Y KSLYS IK DTSG Sbjct: 249 KPAYFAERLYKSMKGLGTDDSTLIRVMVSRAEIDMLDIRANFKRLYGKSLYSFIKGDTSG 308 Query: 312 EYKKTLLKLSGGDD 325 +Y+K LL L GGDD Sbjct: 309 DYRKVLLILCGGDD 322 Score = 328 bits (841), Expect = 4e-90, Method: Compositional matrix adjust. Identities = 166/321 (51%), Positives = 228/321 (71%), Gaps = 9/321 (2%) Query: 355 GTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLM 414 GTV+ A+ FN DA+ LRKAMKGLGTDED II ++ R+ QRQ+IR +KS GRDL+ Sbjct: 9 GTVKAASGFNATEDAQVLRKAMKGLGTDEDAIIGVLACRNTAQRQEIRTAYKSTIGRDLL 68 Query: 415 TDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAIN 474 DLKSE+S + ++ILG+M P YD ++L++AM+GAGTDE LIEILA+R EIR IN Sbjct: 69 EDLKSELSSNFEQVILGMMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRNPEEIRRIN 128 Query: 475 EAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQA--REDAQVAAEILEI 532 + Y++ Y +SLE+ + SDTS F+R+L+SL G R+E G LD A ++DAQ ++ E Sbjct: 129 QTYQQQYGRSLEEDICSDTSFMFQRVLVSLTAGGRDE-GNYLDDALVKQDAQ---DLYEA 184 Query: 533 ADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVA 592 + G E +F++ILC+R+ HL VF E+ +++ D+E +IK E SG DA +A Sbjct: 185 GEKRWGTD---EVKFLSILCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLA 241 Query: 593 IVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQA 652 IV+ ++NKP +FA++LYKSMKG GTD+ TL R+MVSR+EID+L+IR F Y KSL+ Sbjct: 242 IVKCMRNKPAYFAERLYKSMKGLGTDDSTLIRVMVSRAEIDMLDIRANFKRLYGKSLYSF 301 Query: 653 IEGDTSGDFLKALLALCGGED 673 I+GDTSGD+ K LL LCGG+D Sbjct: 302 IKGDTSGDYRKVLLILCGGDD 322 Score = 92.4 bits (228), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 76/288 (26%), Positives = 137/288 (47%), Gaps = 52/288 (18%) Query: 193 GTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRST 252 GTDE I +L R+ + + Y T G+ + ++ ELS +FE+++L ++ T Sbjct: 34 GTDEDAIIGVLACRNTAQRQEIRTAYKSTIGRDLLEDLKSELSSNFEQVILGMMT---PT 90 Query: 253 PEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGE 312 Y + L +AMKG GT + LI I+ SR+ ++ I + ++ +Y +SL I +DTS Sbjct: 91 VLYDVQELRRAMKGAGTDEGCLIEILASRNPEEIRRINQTYQQQYGRSLEEDICSDTSFM 150 Query: 313 YKKTLLKLSGGDDDAAGQFFPEA-----AQVAYQM----W-------------------- 343 +++ L+ L+ G D G + +A AQ Y+ W Sbjct: 151 FQRVLVSLTAGGRD-EGNYLDDALVKQDAQDLYEAGEKRWGTDEVKFLSILCSRNRNHLL 209 Query: 344 ----ELSAVARVELKGTVRP--ANDF-------------NPDADAKALRKAMKGLGTDED 384 E +++ +++ +++ + F P A+ L K+MKGLGTD+ Sbjct: 210 HVFDEYKRISQKDIEQSIKSETSGSFEDALLAIVKCMRNKPAYFAERLYKSMKGLGTDDS 269 Query: 385 TIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARLILGL 432 T+I ++ R+ + IR FK +G+ L + +K + SGD +++L L Sbjct: 270 TLIRVMVSRAEIDMLDIRANFKRLYGKSLYSFIKGDTSGDYRKVLLIL 317 >1I4A-A nrPDB Length = 318 Score = 342 bits (877), Expect = 3e-94, Method: Compositional matrix adjust. Identities = 168/314 (53%), Positives = 227/314 (72%) Query: 12 GSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLI 71 G + GF+ +DA+ L AMKG G+D++AI++++ RS QRQE+ +YK+ G+DL+ Sbjct: 5 GDVKAASGFNAAEDAQTLRKAMKGLGTDEDAIINVLAYRSTAQRQEIRTAYKTTIGRDLM 64 Query: 72 ADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLV 131 DLK EL+G FE++I+G+M P D +E++ A+ G GTDE CLIEILASRT E++ ++ Sbjct: 65 DDLKSELSGNFEQVILGMMTPTVLYDVQELRKAMKGAGTDEGCLIEILASRTPEEIRRIN 124 Query: 132 AAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELK 191 Y+ Y R LE DI DTS FQ++LV L G R+E + + + L++QD QDLYEAGE K Sbjct: 125 QTYQLQYGRSLEDDIRSDTSFMFQRVLVSLSAGGRDESNYLDDALMRQDAQDLYEAGEKK 184 Query: 192 WGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRS 251 WGTDE +F+ +L +R++ HL VFDEY + K IE SI+ E SG FE +LA+VKC+R+ Sbjct: 185 WGTDEVKFLTVLCSRNRNHLLHVFDEYKRIAQKDIEQSIKSETSGSFEDALLAIVKCMRN 244 Query: 252 TPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSG 311 YFAERL+K+MKGLGT D+TLIR+MVSR+E+DMLDIR F+ Y KSLYS IK DTSG Sbjct: 245 KSAYFAERLYKSMKGLGTDDDTLIRVMVSRAEIDMLDIRANFKRLYGKSLYSFIKGDTSG 304 Query: 312 EYKKTLLKLSGGDD 325 +Y+K LL L GGDD Sbjct: 305 DYRKVLLILCGGDD 318 Score = 331 bits (849), Expect = 5e-91, Method: Compositional matrix adjust. Identities = 169/321 (52%), Positives = 229/321 (71%), Gaps = 9/321 (2%) Query: 355 GTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLM 414 G V+ A+ FN DA+ LRKAMKGLGTDED II+++ +RS QRQ+IR +K+ GRDLM Sbjct: 5 GDVKAASGFNAAEDAQTLRKAMKGLGTDEDAIINVLAYRSTAQRQEIRTAYKTTIGRDLM 64 Query: 415 TDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAIN 474 DLKSE+SG+ ++ILG+M P YD ++L+KAM+GAGTDE LIEILA+RT EIR IN Sbjct: 65 DDLKSELSGNFEQVILGMMTPTVLYDVQELRKAMKGAGTDEGCLIEILASRTPEEIRRIN 124 Query: 475 EAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQA--REDAQVAAEILEI 532 + Y+ Y +SLED + SDTS F+R+L+SL+ G R+E LD A R+DAQ ++ E Sbjct: 125 QTYQLQYGRSLEDDIRSDTSFMFQRVLVSLSAGGRDE-SNYLDDALMRQDAQ---DLYEA 180 Query: 533 ADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVA 592 + G + E +F+T+LC+R+ HL VF E+ ++ D+E +IK E SG DA +A Sbjct: 181 GEKKWG---TDEVKFLTVLCSRNRNHLLHVFDEYKRIAQKDIEQSIKSETSGSFEDALLA 237 Query: 593 IVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQA 652 IV+ ++NK +FA++LYKSMKG GTD+ TL R+MVSR+EID+L+IR F Y KSL+ Sbjct: 238 IVKCMRNKSAYFAERLYKSMKGLGTDDDTLIRVMVSRAEIDMLDIRANFKRLYGKSLYSF 297 Query: 653 IEGDTSGDFLKALLALCGGED 673 I+GDTSGD+ K LL LCGG+D Sbjct: 298 IKGDTSGDYRKVLLILCGGDD 318 Score = 100 bits (248), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 85/301 (28%), Positives = 146/301 (48%), Gaps = 51/301 (16%) Query: 179 QDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDF 238 +D Q L +A + GTDE I +L RS + + Y T G+ + ++ ELSG+F Sbjct: 17 EDAQTLRKAMK-GLGTDEDAIINVLAYRSTAQRQEIRTAYKTTIGRDLMDDLKSELSGNF 75 Query: 239 EKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYE 298 E+++L ++ T Y + L KAMKG GT + LI I+ SR+ ++ I + ++ +Y Sbjct: 76 EQVILGMMT---PTVLYDVQELRKAMKGAGTDEGCLIEILASRTPEEIRRINQTYQLQYG 132 Query: 299 KSLYSMIKNDTSGEYKKTLLKLSGGDDDAAG----QFFPEAAQVAYQM----W------- 343 +SL I++DTS +++ L+ LS G D + + AQ Y+ W Sbjct: 133 RSLEDDIRSDTSFMFQRVLVSLSAGGRDESNYLDDALMRQDAQDLYEAGEKKWGTDEVKF 192 Query: 344 -----------------ELSAVARVELKGTVRP--ANDF------------NPDAD-AKA 371 E +A+ +++ +++ + F N A A+ Sbjct: 193 LTVLCSRNRNHLLHVFDEYKRIAQKDIEQSIKSETSGSFEDALLAIVKCMRNKSAYFAER 252 Query: 372 LRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARLILG 431 L K+MKGLGTD+DT+I ++ R+ + IR FK +G+ L + +K + SGD +++L Sbjct: 253 LYKSMKGLGTDDDTLIRVMVSRAEIDMLDIRANFKRLYGKSLYSFIKGDTSGDYRKVLLI 312 Query: 432 L 432 L Sbjct: 313 L 313 >1AII-A nrPDB Length = 323 Score = 327 bits (838), Expect = 1e-89, Method: Compositional matrix adjust. Identities = 164/316 (51%), Positives = 224/316 (70%) Query: 10 YRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKD 69 +RG++ D+P F P+ DAEA+ A++G G+D++ ++ I+T RSN QRQ + + Y++ YGK+ Sbjct: 8 HRGTVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISILTERSNAQRQLIVKEYQAAYGKE 67 Query: 70 LIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQ 129 L DLK +L+G FE L+V L+ PPA DAK++K ++ G GT+E LIEIL +RT+ QM Sbjct: 68 LKDDLKGDLSGHFEHLMVALVTPPAVFDAKQLKKSMKGAGTNEDALIEILTTRTSRQMKD 127 Query: 130 LVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGE 189 + AY Y++ L DI +TSG F+K L+ L G R+E V E L +QD Q LY+AGE Sbjct: 128 ISQAYYTVYKKSLGDDISSETSGDFRKALLTLADGRRDESLKVDEHLAKQDAQILYKAGE 187 Query: 190 LKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCI 249 +WGTDE +F IL RS L+L FDEY + K I SI+GELSG FE L+LA+V C+ Sbjct: 188 NRWGTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIVDSIKGELSGHFEDLLLAIVNCV 247 Query: 250 RSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDT 309 R+TP + AERL +A+KG+GT + TL RIMVSRSE+D+LDIR F+ Y SLYS IK+DT Sbjct: 248 RNTPAFLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRTEFKKHYGYSLYSAIKSDT 307 Query: 310 SGEYKKTLLKLSGGDD 325 SG+Y+ TLLK+ GGDD Sbjct: 308 SGDYEITLLKICGGDD 323 Score = 299 bits (765), Expect = 3e-81, Method: Compositional matrix adjust. Identities = 156/323 (48%), Positives = 226/323 (69%), Gaps = 11/323 (3%) Query: 354 KGTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDL 413 +GTVR DF+P DA+A++KA++G+GTDE +I I+T RSN QRQ I + +++ +G++L Sbjct: 9 RGTVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISILTERSNAQRQLIVKEYQAAYGKEL 68 Query: 414 MTDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAI 473 DLK ++SG L++ L+ PPA +DAKQLKK+M+GAGT+E ALIEIL TRT+ +++ I Sbjct: 69 KDDLKGDLSGHFEHLMVALVTPPAVFDAKQLKKSMKGAGTNEDALIEILTTRTSRQMKDI 128 Query: 474 NEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEG---GENLDQAREDAQVAAEIL 530 ++AY Y KSL D +SS+TSG FR+ L++LA G R+E E+L A++DAQ+ + Sbjct: 129 SQAYYTVYKKSLGDDISSETSGDFRKALLTLADGRRDESLKVDEHL--AKQDAQI---LY 183 Query: 531 EIADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAF 590 + + G + E +F ILC RS+P L+ F E+ ++ D+ +IK E+SG D Sbjct: 184 KAGENRWG---TDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIVDSIKGELSGHFEDLL 240 Query: 591 VAIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLH 650 +AIV V+N P F A++L++++KG GTDE TL RIMVSRSEIDLL+IR EF + Y SL+ Sbjct: 241 LAIVNCVRNTPAFLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRTEFKKHYGYSLY 300 Query: 651 QAIEGDTSGDFLKALLALCGGED 673 AI+ DTSGD+ LL +CGG+D Sbjct: 301 SAIKSDTSGDYEITLLKICGGDD 323 Score = 141 bits (356), Expect = 9e-34, Method: Compositional matrix adjust. Identities = 104/321 (32%), Positives = 167/321 (52%), Gaps = 40/321 (12%) Query: 193 GTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRST 252 GTDE I IL RS +L+ EY GK ++ ++G+LSG FE LM+A+V + Sbjct: 35 GTDEKMLISILTERSNAQRQLIVKEYQAAYGKELKDDLKGDLSGHFEHLMVALV----TP 90 Query: 253 PEYF-AERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSG 311 P F A++L K+MKG GT ++ LI I+ +R+ M DI + + T Y+KSL I ++TSG Sbjct: 91 PAVFDAKQLKKSMKGAGTNEDALIEILTTRTSRQMKDISQAYYTVYKKSLGDDISSETSG 150 Query: 312 EYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPANDFNPDADAKA 371 +++K LL L+ G D + + A+ DA+ Sbjct: 151 DFRKALLTLADGRRDESLKVDEHLAK-----------------------------QDAQI 181 Query: 372 LRKAMKG-LGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARLIL 430 L KA + GTDED +I+ RS Q + +++ +D++ +K E+SG L+L Sbjct: 182 LYKAGENRWGTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIVDSIKGELSGHFEDLLL 241 Query: 431 GLM----MPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKSLE 486 ++ PA + A++L +A++G GTDE L I+ +R+ ++ I +K+ Y SL Sbjct: 242 AIVNCVRNTPA-FLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRTEFKKHYGYSLY 300 Query: 487 DALSSDTSGHFRRILISLATG 507 A+ SDTSG + L+ + G Sbjct: 301 SAIKSDTSGDYEITLLKICGG 321 >1W3W-A nrPDB Length = 327 Score = 319 bits (818), Expect = 2e-87, Method: Compositional matrix adjust. Identities = 171/322 (53%), Positives = 219/322 (68%), Gaps = 9/322 (2%) Query: 6 QGAKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSL 65 +G + S H F+P+ DAE LY AMKG G++++AI+D++T RSN QRQ++ +S+K+ Sbjct: 11 EGVTVKSSSH----FNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIAKSFKAQ 66 Query: 66 YGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNE 125 +GKDL LK EL+GKFERLIV LM PP +AKE+ DA+ G+GT E +IEILASRT Sbjct: 67 FGKDLTETLKSELSGKFERLIVALMYPPYRYEAKELHDAMKGLGTKEGVIIEILASRTKN 126 Query: 126 QMHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDV---VSEDLVQQDVQ 182 Q+ +++ AY++ Y LE DI DTSG+ +++LV LLQG+R DDV V L QD Q Sbjct: 127 QLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCLLQGSR--DDVSSFVDPALALQDAQ 184 Query: 183 DLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLM 242 DLY AGE GTDE +FI IL RS HL VF+EY K K IE SI+ E G E+ M Sbjct: 185 DLYAAGEKIRGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSETHGSLEEAM 244 Query: 243 LAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLY 302 L VVKC ++ YFAERL+ AMKG GTRD TLIR +VSRSE+D+ I+ F+ Y K+L Sbjct: 245 LTVVKCTQNLHSYFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLS 304 Query: 303 SMIKNDTSGEYKKTLLKLSGGD 324 SMI DTSG+YK LL L G D Sbjct: 305 SMIMEDTSGDYKNALLSLVGSD 326 Score = 291 bits (746), Expect = 5e-79, Method: Compositional matrix adjust. Identities = 158/330 (47%), Positives = 218/330 (66%), Gaps = 15/330 (4%) Query: 349 ARVELKG-TVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKS 407 A +E +G TV+ ++ FNPD DA+ L KAMKG+GT+E IID++T RSN QRQQI ++FK+ Sbjct: 6 AWIEQEGVTVKSSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIAKSFKA 65 Query: 408 HFGRDLMTDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTN 467 FG+DL LKSE+SG RLI+ LM PP Y+AK+L AM+G GT E +IEILA+RT Sbjct: 66 QFGKDLTETLKSELSGKFERLIVALMYPPYRYEAKELHDAMKGLGTKEGVIIEILASRTK 125 Query: 468 AEIRAINEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQ--AREDAQ- 524 ++R I +AY+EDY SLE+ + +DTSG+ RIL+ L G R++ +D A +DAQ Sbjct: 126 NQLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCLLQGSRDDVSSFVDPALALQDAQD 185 Query: 525 --VAAEILEIADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEM 582 A E + D E +F+TILCTRS HL RVF+E+ K+ N +E +IK E Sbjct: 186 LYAAGEKIRGTD---------EMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSET 236 Query: 583 SGDVRDAFVAIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFI 642 G + +A + +V+ +N +FA++LY +MKGAGT + TL R +VSRSEIDL I+ F Sbjct: 237 HGSLEEAMLTVVKCTQNLHSYFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFK 296 Query: 643 EKYDKSLHQAIEGDTSGDFLKALLALCGGE 672 + Y K+L I DTSGD+ ALL+L G + Sbjct: 297 KMYGKTLSSMIMEDTSGDYKNALLSLVGSD 326 Score = 110 bits (276), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 92/329 (27%), Positives = 156/329 (47%), Gaps = 34/329 (10%) Query: 180 DVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFE 239 D + LY+A + GT+E I +L RS + + + GK + +++ ELSG FE Sbjct: 26 DAETLYKAMK-GIGTNEQAIIDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSELSGKFE 84 Query: 240 KLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEK 299 +L++A+ + Y A+ L AMKGLGT++ +I I+ SR++ + +I + + Y Sbjct: 85 RLIVAL---MYPPYRYEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEEDYGS 141 Query: 300 SLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRP 359 SL I+ DTSG ++ L+ L G D F V P Sbjct: 142 SLEEDIQADTSGYLERILVCLLQGSRDDVSSF-------------------------VDP 176 Query: 360 ANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKS 419 A D A + ++ GTDE I I+ RS ++ + ++ + + +KS Sbjct: 177 ALALQDAQDLYAAGEKIR--GTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKS 234 Query: 420 EISGDLARLILGLMMPPAH---YDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEA 476 E G L +L ++ + Y A++L AM+GAGT + LI + +R+ ++ I Sbjct: 235 ETHGSLEEAMLTVVKCTQNLHSYFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCH 294 Query: 477 YKEDYHKSLEDALSSDTSGHFRRILISLA 505 +K+ Y K+L + DTSG ++ L+SL Sbjct: 295 FKKMYGKTLSSMIMEDTSGDYKNALLSLV 323 >5N7D-A nrPDB Length = 427 Score = 293 bits (751), Expect = 1e-79, Method: Compositional matrix adjust. Identities = 153/320 (47%), Positives = 216/320 (67%), Gaps = 1/320 (0%) Query: 7 GAKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLY 66 G+ GS+ + FD +DA + TA+K G D+ I++I+T+RSN QRQ++ +Y+ Sbjct: 108 GSSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRT 167 Query: 67 GKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQ 126 K+L + LK L+G E +I+GL++ PA DA E+K ++ G+GTDE LIEI+ SRTN++ Sbjct: 168 KKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQE 227 Query: 127 MHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREED-DVVSEDLVQQDVQDLY 185 + ++ YK+ Y+ DLE DII DTSG F+K++V L +G R ED V+ +L+ QD +DLY Sbjct: 228 LQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLY 287 Query: 186 EAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAV 245 +AG + GTD ++I I+ RS HL+ VFD Y + + SIR E+ GD E L + Sbjct: 288 DAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNL 347 Query: 246 VKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMI 305 V+CI++ P YFA+RL+ +MKG GTRD LIRIMVSRSE+DML IR F+ KY KSLY I Sbjct: 348 VQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYI 407 Query: 306 KNDTSGEYKKTLLKLSGGDD 325 + DT G+Y+K LL L GGDD Sbjct: 408 QQDTKGDYQKALLYLCGGDD 427 Score = 287 bits (734), Expect = 1e-77, Method: Compositional matrix adjust. Identities = 150/324 (46%), Positives = 213/324 (65%), Gaps = 14/324 (4%) Query: 355 GTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLM 414 G+V+ +F+ + DA + A+K G DE TI++I+T+RSN QRQ I ++ ++L Sbjct: 113 GSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELA 172 Query: 415 TDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAIN 474 + LKS +SG L +ILGL+ PA YDA +LK +M+G GTDE +LIEI+ +RTN E++ IN Sbjct: 173 SALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEIN 232 Query: 475 EAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGG-----ENLDQAREDAQVAAEI 529 YKE Y LE + SDTSG FR+++++LA G R E G E +DQ D A Sbjct: 233 RVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVK 292 Query: 530 LEIADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDA 589 + D P ++++I+ RS PHL++VF + + YD+ +I+KE+ GD+ +A Sbjct: 293 RKGTDVP---------KWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENA 343 Query: 590 FVAIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSL 649 F+ +VQ ++NKPL+FAD+LY SMKG GT +K L RIMVSRSE+D+L IR EF KY KSL Sbjct: 344 FLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSL 403 Query: 650 HQAIEGDTSGDFLKALLALCGGED 673 + I+ DT GD+ KALL LCGG+D Sbjct: 404 YYYIQQDTKGDYQKALLYLCGGDD 427 >4X9P-A nrPDB Length = 343 Score = 290 bits (741), Expect = 2e-78, Method: Compositional matrix adjust. Identities = 149/315 (47%), Positives = 214/315 (67%), Gaps = 1/315 (0%) Query: 12 GSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLI 71 GS+ + FD +DA + TA+K G D+ I++I+T+RSN QRQ++ +Y+ K+L Sbjct: 29 GSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELA 88 Query: 72 ADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLV 131 + LK L+G E +I+GL++ PA DA E+K ++ G+GTDE LIEI+ SRTN+++ ++ Sbjct: 89 SALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEIN 148 Query: 132 AAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREED-DVVSEDLVQQDVQDLYEAGEL 190 YK+ Y+ DLE DI+ DTSG F+K++V L +G R ED V+ +L+ QD +DLY+AG Sbjct: 149 RVYKEMYKTDLEKDIVSDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVK 208 Query: 191 KWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIR 250 + GTD ++I I+ RS HL+ VF+ Y + + SI+ E+ GD E L +V+CI+ Sbjct: 209 RKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQ 268 Query: 251 STPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTS 310 + P YFA+RL+ +MKG GTRD LIRIMVSRSE+DML IR F+ KY KSLY I+ DT Sbjct: 269 NKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTK 328 Query: 311 GEYKKTLLKLSGGDD 325 G+Y+K LL L GGDD Sbjct: 329 GDYQKALLYLCGGDD 343 Score = 287 bits (735), Expect = 1e-77, Method: Compositional matrix adjust. Identities = 150/324 (46%), Positives = 214/324 (66%), Gaps = 14/324 (4%) Query: 355 GTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLM 414 G+V+ +F+ + DA + A+K G DE TI++I+T+RSN QRQ I ++ ++L Sbjct: 29 GSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELA 88 Query: 415 TDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAIN 474 + LKS +SG L +ILGL+ PA YDA +LK +M+G GTDE +LIEI+ +RTN E++ IN Sbjct: 89 SALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEIN 148 Query: 475 EAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGG-----ENLDQAREDAQVAAEI 529 YKE Y LE + SDTSG FR+++++LA G R E G E +DQ D A Sbjct: 149 RVYKEMYKTDLEKDIVSDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVK 208 Query: 530 LEIADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDA 589 + D P ++++I+ RS HL++VF+ + + YD+ +IKKE+ GD+ +A Sbjct: 209 RKGTDVP---------KWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENA 259 Query: 590 FVAIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSL 649 F+ +VQ ++NKPL+FAD+LY SMKG GT +K L RIMVSRSE+D+L IR EF +KY KSL Sbjct: 260 FLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSL 319 Query: 650 HQAIEGDTSGDFLKALLALCGGED 673 + I+ DT GD+ KALL LCGG+D Sbjct: 320 YYYIQQDTKGDYQKALLYLCGGDD 343 >6B3I-A nrPDB Length = 343 Score = 285 bits (728), Expect = 5e-77, Method: Compositional matrix adjust. Identities = 145/319 (45%), Positives = 218/319 (68%), Gaps = 4/319 (1%) Query: 6 QGAKYRGSIH---DFP-GFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQS 61 QGA G+ H P GFD ++DA+ L A KG G+++ AI++I++ R++ +RQ++ Q Sbjct: 23 QGAMEMGNRHAKASSPQGFDVDRDAKKLNKACKGMGTNEAAIIEILSGRTSDERQQIKQK 82 Query: 62 YKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILAS 121 YK+ YGK+L LK EL+G FE+ + L+ P+ A++++ A+ G+GTDE LIE+L + Sbjct: 83 YKATYGKELEEVLKSELSGNFEKTALALLDHPSEYAARQLQKAMKGLGTDESVLIEVLCT 142 Query: 122 RTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDV 181 RTN+++ + AY+ ++R LE+D+ GDTSG+ +K+LV LLQ R E D V +DL QD Sbjct: 143 RTNKEIIAIKEAYQRLFDRSLESDVKGDTSGNLKKILVSLLQANRNEGDDVDKDLAGQDA 202 Query: 182 QDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKL 241 +DLY+AGE +WGTDE F +L RS + LR F Y GK IE +I E SGD +K Sbjct: 203 KDLYDAGEGRWGTDELAFNEVLAKRSYKQLRATFQAYQILIGKDIEEAIEEETSGDLQKA 262 Query: 242 MLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSL 301 L +V+C + +YFAERL+K+MKG GT + TLIRI+V+R+E+D+ I+ F+ KY+KSL Sbjct: 263 YLTLVRCAQDCEDYFAERLYKSMKGAGTDEETLIRIIVTRAEVDLQGIKAKFQEKYQKSL 322 Query: 302 YSMIKNDTSGEYKKTLLKL 320 M+++DTSG+++K L+ L Sbjct: 323 SDMVRSDTSGDFRKLLVAL 341 Score = 266 bits (679), Expect = 3e-71, Method: Compositional matrix adjust. Identities = 141/307 (45%), Positives = 207/307 (67%), Gaps = 7/307 (2%) Query: 363 FNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEIS 422 F+ D DAK L KA KG+GT+E II+I++ R++ +RQQI+Q +K+ +G++L LKSE+S Sbjct: 41 FDVDRDAKKLNKACKGMGTNEAAIIEILSGRTSDERQQIKQKYKATYGKELEEVLKSELS 100 Query: 423 GDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYH 482 G+ + L L+ P+ Y A+QL+KAM+G GTDE LIE+L TRTN EI AI EAY+ + Sbjct: 101 GNFEKTALALLDHPSEYAARQLQKAMKGLGTDESVLIEVLCTRTNKEIIAIKEAYQRLFD 160 Query: 483 KSLEDALSSDTSGHFRRILISLATGHREEGGE-NLDQAREDAQVAAEILEIADTPSGDKT 541 +SLE + DTSG+ ++IL+SL +R EG + + D A +DA+ ++ D G Sbjct: 161 RSLESDVKGDTSGNLKKILVSLLQANRNEGDDVDKDLAGQDAK------DLYDAGEGRWG 214 Query: 542 SLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNKP 601 + E F +L RSY LR FQ + + D+E I++E SGD++ A++ +V+ ++ Sbjct: 215 TDELAFNEVLAKRSYKQLRATFQAYQILIGKDIEEAIEEETSGDLQKAYLTLVRCAQDCE 274 Query: 602 LFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGDF 661 +FA++LYKSMKGAGTDE+TL RI+V+R+E+DL I+ +F EKY KSL + DTSGDF Sbjct: 275 DYFAERLYKSMKGAGTDEETLIRIIVTRAEVDLQGIKAKFQEKYQKSLSDMVRSDTSGDF 334 Query: 662 LKALLAL 668 K L+AL Sbjct: 335 RKLLVAL 341 Score = 114 bits (284), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 98/362 (27%), Positives = 170/362 (46%), Gaps = 71/362 (19%) Query: 251 STPEYF-----AERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMI 305 S+P+ F A++L KA KG+GT + +I I+ R+ + I++ ++ Y K L ++ Sbjct: 36 SSPQGFDVDRDAKKLNKACKGMGTNEAAIIEILSGRTSDERQQIKQKYKATYGKELEEVL 95 Query: 306 KNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPANDFNP 365 K++ SG ++KT L L D Sbjct: 96 KSELSGNFEKTALALL----------------------------------------DHPS 115 Query: 366 DADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDL 425 + A+ L+KAMKGLGTDE +I+++ R+N + I++ ++ F R L +D+K + SG+L Sbjct: 116 EYAARQLQKAMKGLGTDESVLIEVLCTRTNKEIIAIKEAYQRLFDRSLESDVKGDTSGNL 175 Query: 426 ARLILGLMMPP-----------AHYDAKQLKKAMEG-AGTDEKALIEILATRTNAEIRAI 473 ++++ L+ A DAK L A EG GTDE A E+LA R+ ++RA Sbjct: 176 KKILVSLLQANRNEGDDVDKDLAGQDAKDLYDAGEGRWGTDELAFNEVLAKRSYKQLRAT 235 Query: 474 NEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIA 533 +AY+ K +E+A+ +TSG ++ ++L A++ AE L Sbjct: 236 FQAYQILIGKDIEEAIEEETSGDLQKAYLTLVRC-----------AQDCEDYFAERL--Y 282 Query: 534 DTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAI 593 + G T ET + I+ TR+ L+ + +F + + ++ + SGD R VA+ Sbjct: 283 KSMKGAGTDEET-LIRIIVTRAEVDLQGIKAKFQEKYQKSLSDMVRSDTSGDFRKLLVAL 341 Query: 594 VQ 595 + Sbjct: 342 LH 343 Score = 95.1 bits (235), Expect = 9e-20, Method: Compositional matrix adjust. Identities = 66/234 (28%), Positives = 127/234 (54%), Gaps = 23/234 (9%) Query: 26 AEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIADLKYELTGKFERL 85 A L AMKG G+D+ +++++ +R+N++ + ++Y+ L+ + L +D+K + +G +++ Sbjct: 119 ARQLQKAMKGLGTDESVLIEVLCTRTNKEIIAIKEAYQRLFDRSLESDVKGDTSGNLKKI 178 Query: 86 IVGLMRPP-----------AYCDAKEIKDAISG-IGTDEKCLIEILASRTNEQMHQLVAA 133 +V L++ A DAK++ DA G GTDE E+LA R+ +Q+ A Sbjct: 179 LVSLLQANRNEGDDVDKDLAGQDAKDLYDAGEGRWGTDELAFNEVLAKRSYKQLRATFQA 238 Query: 134 YKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELKW- 192 Y+ +D+E I +TSG QK + L++ ++ +D +E L + +K Sbjct: 239 YQILIGKDIEEAIEEETSGDLQKAYLTLVRCAQDCEDYFAERLYKS----------MKGA 288 Query: 193 GTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVV 246 GTDE I I+ R++ L+ + ++ + K + +R + SGDF KL++A++ Sbjct: 289 GTDEETLIRIIVTRAEVDLQGIKAKFQEKYQKSLSDMVRSDTSGDFRKLLVALL 342 Score = 80.9 bits (198), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 47/144 (32%), Positives = 85/144 (59%), Gaps = 4/144 (2%) Query: 24 QDAEALYTAMKG-FGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIADLKYELTGKF 82 QDA+ LY A +G +G+D+ A +++ RS +Q + Q+Y+ L GKD+ ++ E +G Sbjct: 200 QDAKDLYDAGEGRWGTDELAFNEVLAKRSYKQLRATFQAYQILIGKDIEEAIEEETSGDL 259 Query: 83 ERLIVGLMRPPAYCD---AKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVAAYKDAYE 139 ++ + L+R C+ A+ + ++ G GTDE+ LI I+ +R + + A +++ Y+ Sbjct: 260 QKAYLTLVRCAQDCEDYFAERLYKSMKGAGTDEETLIRIIVTRAEVDLQGIKAKFQEKYQ 319 Query: 140 RDLEADIIGDTSGHFQKMLVVLLQ 163 + L + DTSG F+K+LV LL Sbjct: 320 KSLSDMVRSDTSGDFRKLLVALLH 343 >1DM5-A nrPDB Length = 315 Score = 279 bits (714), Expect = 2e-75, Method: Compositional matrix adjust. Identities = 141/312 (45%), Positives = 210/312 (67%) Query: 11 RGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDL 70 +G++ F+ +DAE L AMKG G+D+++I I+ +RSN QRQ++ Y +L+GK L Sbjct: 3 QGTVKPHASFNSREDAETLRKAMKGIGTDEKSITHILATRSNAQRQQIKTDYTTLFGKHL 62 Query: 71 IADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQL 130 +LK EL+G +E + L+R P A+++ A+ G+GTD+ LI+IL +++N Q+H + Sbjct: 63 EDELKSELSGNYEAAALALLRKPDEFLAEQLHAAMKGLGTDKNALIDILCTQSNAQIHAI 122 Query: 131 VAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGEL 190 AA+K Y+ DLE +II +TSG+FQ++LV +LQG R+ED+ V+ +D +Y+AGE Sbjct: 123 KAAFKLLYKEDLEKEIISETSGNFQRLLVSMLQGGRKEDEPVNAAHAAEDAAAIYQAGEG 182 Query: 191 KWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIR 250 + GTDE++F +L RS L +F EY K + K I +I E SGD + +LA+VK + Sbjct: 183 QIGTDESRFNAVLATRSYPQLHQIFHEYSKISNKTILQAIENEFSGDIKNGLLAIVKSVE 242 Query: 251 STPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTS 310 + YFAERL AMKGLGT D TLIRI+VSRSE+D+ +I+E F+ Y KSLY I +D S Sbjct: 243 NRFAYFAERLHHAMKGLGTSDKTLIRILVSRSEIDLANIKETFQAMYGKSLYEFIADDCS 302 Query: 311 GEYKKTLLKLSG 322 G+YK LL+++G Sbjct: 303 GDYKDLLLQITG 314 Score = 269 bits (688), Expect = 3e-72, Method: Compositional matrix adjust. Identities = 143/318 (44%), Positives = 207/318 (65%), Gaps = 5/318 (1%) Query: 353 LKGTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRD 412 ++GTV+P FN DA+ LRKAMKG+GTDE +I I+ RSN QRQQI+ + + FG+ Sbjct: 2 VQGTVKPHASFNSREDAETLRKAMKGIGTDEKSITHILATRSNAQRQQIKTDYTTLFGKH 61 Query: 413 LMTDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRA 472 L +LKSE+SG+ L L+ P + A+QL AM+G GTD+ ALI+IL T++NA+I A Sbjct: 62 LEDELKSELSGNYEAAALALLRKPDEFLAEQLHAAMKGLGTDKNALIDILCTQSNAQIHA 121 Query: 473 INEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEI 532 I A+K Y + LE + S+TSG+F+R+L+S+ G R+E D+ A A + I Sbjct: 122 IKAAFKLLYKEDLEKEIISETSGNFQRLLVSMLQGGRKE-----DEPVNAAHAAEDAAAI 176 Query: 533 ADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVA 592 G + E+RF +L TRSYP L ++F E+ K++N + I+ E SGD+++ +A Sbjct: 177 YQAGEGQIGTDESRFNAVLATRSYPQLHQIFHEYSKISNKTILQAIENEFSGDIKNGLLA 236 Query: 593 IVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQA 652 IV+SV+N+ +FA++L+ +MKG GT +KTL RI+VSRSEIDL NI+ F Y KSL++ Sbjct: 237 IVKSVENRFAYFAERLHHAMKGLGTSDKTLIRILVSRSEIDLANIKETFQAMYGKSLYEF 296 Query: 653 IEGDTSGDFLKALLALCG 670 I D SGD+ LL + G Sbjct: 297 IADDCSGDYKDLLLQITG 314 Score = 127 bits (319), Expect = 1e-29, Method: Compositional matrix adjust. Identities = 96/321 (29%), Positives = 161/321 (50%), Gaps = 39/321 (12%) Query: 193 GTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRST 252 GTDE +IL RS + + +Y GK +E ++ ELSG++E LA+ +R Sbjct: 29 GTDEKSITHILATRSNAQRQQIKTDYTTLFGKHLEDELKSELSGNYEAAALAL---LRKP 85 Query: 253 PEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGE 312 E+ AE+L AMKGLGT N LI I+ ++S + I+ F+ Y++ L I ++TSG Sbjct: 86 DEFLAEQLHAAMKGLGTDKNALIDILCTQSNAQIHAIKAAFKLLYKEDLEKEIISETSGN 145 Query: 313 YKKTLLK-LSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPANDFNPDADAKA 371 +++ L+ L GG + P N + DA A Sbjct: 146 FQRLLVSMLQGGRKED------------------------------EPVNAAHAAEDAAA 175 Query: 372 LRKAMKG-LGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARLIL 430 + +A +G +GTDE ++ RS Q QI + + ++ +++E SGD+ +L Sbjct: 176 IYQAGEGQIGTDESRFNAVLATRSYPQLHQIFHEYSKISNKTILQAIENEFSGDIKNGLL 235 Query: 431 GLMMPPAH---YDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKSLED 487 ++ + Y A++L AM+G GT +K LI IL +R+ ++ I E ++ Y KSL + Sbjct: 236 AIVKSVENRFAYFAERLHHAMKGLGTSDKTLIRILVSRSEIDLANIKETFQAMYGKSLYE 295 Query: 488 ALSSDTSGHFRRILISLATGH 508 ++ D SG ++ +L+ + TGH Sbjct: 296 FIADDCSGDYKDLLLQI-TGH 315 Score = 89.4 bits (220), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 95/352 (26%), Positives = 152/352 (43%), Gaps = 70/352 (19%) Query: 257 AERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKT 316 AE L KAMKG+GT + ++ I+ +RS I+ + T + K L +K++ SG Y Sbjct: 18 AETLRKAMKGIGTDEKSITHILATRSNAQRQQIKTDYTTLFGKHLEDELKSELSGNY--- 74 Query: 317 LLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPANDFNPDADAKALRKAM 376 EAA +A +R ++F A+ L AM Sbjct: 75 -----------------EAAALAL----------------LRKPDEFL----AEQLHAAM 97 Query: 377 KGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARLILGLMMPP 436 KGLGTD++ +IDI+ +SN Q I+ FK + DL ++ SE SG+ RL++ ++ Sbjct: 98 KGLGTDKNALIDILCTQSNAQIHAIKAAFKLLYKEDLEKEIISETSGNFQRLLVSMLQGG 157 Query: 437 AHYD-----------AKQLKKAMEGA-GTDEKALIEILATRTNAEIRAINEAYKEDYHKS 484 D A + +A EG GTDE +LATR+ ++ I Y + +K+ Sbjct: 158 RKEDEPVNAAHAAEDAAAIYQAGEGQIGTDESRFNAVLATRSYPQLHQIFHEYSKISNKT 217 Query: 485 LEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSG--DKTS 542 + A+ ++ SG + L+++ + AE L A G DKT Sbjct: 218 ILQAIENEFSGDIKNGLLAI-----------VKSVENRFAYFAERLHHAMKGLGTSDKT- 265 Query: 543 LETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIV 594 + IL +RS L + + F M + I + SGD +D + I Sbjct: 266 ----LIRILVSRSEIDLANIKETFQAMYGKSLYEFIADDCSGDYKDLLLQIT 313 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 38/129 (29%), Positives = 70/129 (54%), Gaps = 5/129 (3%) Query: 544 ETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNKP-L 602 E IL TRS +++ ++ + +E +K E+SG+ A +A+++ KP Sbjct: 32 EKSITHILATRSNAQRQQIKTDYTTLFGKHLEDELKSELSGNYEAAALALLR----KPDE 87 Query: 603 FFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGDFL 662 F A++L+ +MKG GTD+ L I+ ++S + I+ F Y + L + I +TSG+F Sbjct: 88 FLAEQLHAAMKGLGTDKNALIDILCTQSNAQIHAIKAAFKLLYKEDLEKEIISETSGNFQ 147 Query: 663 KALLALCGG 671 + L+++ G Sbjct: 148 RLLVSMLQG 156 >1AIN-A nrPDB Length = 314 Score = 273 bits (697), Expect = 2e-73, Method: Compositional matrix adjust. Identities = 149/316 (47%), Positives = 200/316 (63%), Gaps = 7/316 (2%) Query: 357 VRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTD 416 V P FNP +D AL KA+ G DE TIIDI+T R+N QRQQI+ + G+ L Sbjct: 4 VSPYPTFNPSSDVAALHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDET 63 Query: 417 LKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEA 476 LK ++G L ++L L+ PA +DA +L+ AM+G GTDE LIEILA+RTN EIR IN Sbjct: 64 LKKALTGHLEEVVLALLKTPAQFDADELRAAMKGLGTDEDTLIEILASRTNKEIRDINRV 123 Query: 477 YKEDYHKSLEDALSSDTSGHFRRILISLATGHR-EEGGENLDQAREDAQVAAEILEIADT 535 Y+E+ + L ++SDTSG FR L+SLA G R E+ G N D A DA+ + E + Sbjct: 124 YREELKRDLAKDITSDTSGDFRNALLSLAKGDRSEDFGVNEDLADSDARA---LYEAGER 180 Query: 536 PSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQ 595 G ++ F TIL TRSYP LRRVFQ++ K + +D+ + E+ GD+ AIV+ Sbjct: 181 RKGTDVNV---FNTILTTRSYPQLRRVFQKYTKYSKHDMNKVLDLELKGDIEKCLTAIVK 237 Query: 596 SVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEG 655 +KP FFA+KL+++MKG GT K L RIMVSRSEID+ +I+ + + Y SL QAI Sbjct: 238 CATSKPAFFAEKLHQAMKGVGTRHKALIRIMVSRSEIDMNDIKAFYQKMYGISLCQAILD 297 Query: 656 DTSGDFLKALLALCGG 671 +T GD+ K L+ALCGG Sbjct: 298 ETKGDYEKILVALCGG 313 Score = 266 bits (680), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 141/312 (45%), Positives = 197/312 (63%) Query: 13 SIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIA 72 ++ +P F+P+ D AL+ A+ G D+ I+DI+T R+N QRQ++ +Y GK L Sbjct: 3 AVSPYPTFNPSSDVAALHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDE 62 Query: 73 DLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVA 132 LK LTG E +++ L++ PA DA E++ A+ G+GTDE LIEILASRTN+++ + Sbjct: 63 TLKKALTGHLEEVVLALLKTPAQFDADELRAAMKGLGTDEDTLIEILASRTNKEIRDINR 122 Query: 133 AYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELKW 192 Y++ +RDL DI DTSG F+ L+ L +G R ED V+EDL D + LYEAGE + Sbjct: 123 VYREELKRDLAKDITSDTSGDFRNALLSLAKGDRSEDFGVNEDLADSDARALYEAGERRK 182 Query: 193 GTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRST 252 GTD F IL RS LR VF +Y K + + + EL GD EK + A+VKC S Sbjct: 183 GTDVNVFNTILTTRSYPQLRRVFQKYTKYSKHDMNKVLDLELKGDIEKCLTAIVKCATSK 242 Query: 253 PEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGE 312 P +FAE+L +AMKG+GTR LIRIMVSRSE+DM DI+ ++ Y SL I ++T G+ Sbjct: 243 PAFFAEKLHQAMKGVGTRHKALIRIMVSRSEIDMNDIKAFYQKMYGISLCQAILDETKGD 302 Query: 313 YKKTLLKLSGGD 324 Y+K L+ L GG+ Sbjct: 303 YEKILVALCGGN 314 Score = 145 bits (365), Expect = 7e-35, Method: Compositional matrix adjust. Identities = 108/335 (32%), Positives = 181/335 (54%), Gaps = 41/335 (12%) Query: 180 DVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFE 239 DV L++A +K G DEA I IL R+ + + YL+ TGKP++ +++ L+G E Sbjct: 15 DVAALHKAIMVK-GVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLE 73 Query: 240 KLMLAVVKCIRSTPEYF-AERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYE 298 +++LA++K TP F A+ L AMKGLGT ++TLI I+ SR+ ++ DI ++R + + Sbjct: 74 EVVLALLK----TPAQFDADELRAAMKGLGTDEDTLIEILASRTNKEIRDINRVYREELK 129 Query: 299 KSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVR 358 + L I +DTSG+++ LL L+ GD R E G Sbjct: 130 RDLAKDITSDTSGDFRNALLSLAKGD-------------------------RSEDFGV-- 162 Query: 359 PANDFNPDADAKALRKA-MKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDL 417 N+ D+DA+AL +A + GTD + I+T RS Q +++ Q + + D+ L Sbjct: 163 --NEDLADSDARALYEAGERRKGTDVNVFNTILTTRSYPQLRRVFQKYTKYSKHDMNKVL 220 Query: 418 KSEISGDLARLILGLM----MPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAI 473 E+ GD+ + + ++ PA + A++L +AM+G GT KALI I+ +R+ ++ I Sbjct: 221 DLELKGDIEKCLTAIVKCATSKPAFF-AEKLHQAMKGVGTRHKALIRIMVSRSEIDMNDI 279 Query: 474 NEAYKEDYHKSLEDALSSDTSGHFRRILISLATGH 508 Y++ Y SL A+ +T G + +IL++L G+ Sbjct: 280 KAFYQKMYGISLCQAILDETKGDYEKILVALCGGN 314 Score = 73.9 bits (180), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 47/148 (31%), Positives = 78/148 (52%), Gaps = 13/148 (8%) Query: 535 TPSGDKTSLETRFMT----------ILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSG 584 PS D +L M IL R+ +++ +++ T ++ T+KK ++G Sbjct: 11 NPSSDVAALHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTG 70 Query: 585 DVRDAFVAIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEK 644 + + +A++ K F AD+L +MKG GTDE TL I+ SR+ ++ +I R + E+ Sbjct: 71 HLEEVVLALL---KTPAQFDADELRAAMKGLGTDEDTLIEILASRTNKEIRDINRVYREE 127 Query: 645 YDKSLHQAIEGDTSGDFLKALLALCGGE 672 + L + I DTSGDF ALL+L G+ Sbjct: 128 LKRDLAKDITSDTSGDFRNALLSLAKGD 155 >1HM6-A nrPDB Length = 346 Score = 269 bits (688), Expect = 3e-72, Method: Compositional matrix adjust. Identities = 143/312 (45%), Positives = 198/312 (63%) Query: 13 SIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIA 72 ++ +P F+P+ D EAL+ A+ G D+ I++I+T R+N QRQ++ +Y GK L Sbjct: 35 AVSPYPTFNPSSDVEALHKAITVKGVDEATIIEILTKRTNAQRQQIKAAYLQEKGKPLDE 94 Query: 73 DLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVA 132 LK LTG E + + L++ PA DA E++ A+ G+GTDE L EILASRTN ++ ++ Sbjct: 95 ALKKALTGHLEEVALALLKTPAQFDADELRAAMKGLGTDEDTLNEILASRTNREIREINR 154 Query: 133 AYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELKW 192 YK+ +RDL DI DTSG +QK L+ L +G R ED +++DL D + LYEAGE + Sbjct: 155 VYKEELKRDLAKDITSDTSGDYQKALLSLAKGDRSEDLAINDDLADTDARALYEAGERRK 214 Query: 193 GTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRST 252 GTD FI IL RS HLR VF +Y K + + + EL GD E + VVKC S Sbjct: 215 GTDLNVFITILTTRSYPHLRRVFQKYSKYSKHDMNKVLDLELKGDIENCLTVVVKCATSK 274 Query: 253 PEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGE 312 P +FAE+L +AMKG+GTR TLIRIMVSRSE+DM DI+ ++ Y SL I ++T G+ Sbjct: 275 PMFFAEKLHQAMKGIGTRHKTLIRIMVSRSEIDMNDIKACYQKLYGISLCQAILDETKGD 334 Query: 313 YKKTLLKLSGGD 324 Y+K L+ L GGD Sbjct: 335 YEKILVALCGGD 346 Score = 267 bits (683), Expect = 1e-71, Method: Compositional matrix adjust. Identities = 145/317 (45%), Positives = 203/317 (64%), Gaps = 7/317 (2%) Query: 357 VRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTD 416 V P FNP +D +AL KA+ G DE TII+I+T R+N QRQQI+ + G+ L Sbjct: 36 VSPYPTFNPSSDVEALHKAITVKGVDEATIIEILTKRTNAQRQQIKAAYLQEKGKPLDEA 95 Query: 417 LKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEA 476 LK ++G L + L L+ PA +DA +L+ AM+G GTDE L EILA+RTN EIR IN Sbjct: 96 LKKALTGHLEEVALALLKTPAQFDADELRAAMKGLGTDEDTLNEILASRTNREIREINRV 155 Query: 477 YKEDYHKSLEDALSSDTSGHFRRILISLATGHREEG-GENLDQAREDAQVAAEILEIADT 535 YKE+ + L ++SDTSG +++ L+SLA G R E N D A DA+ + E + Sbjct: 156 YKEELKRDLAKDITSDTSGDYQKALLSLAKGDRSEDLAINDDLADTDARA---LYEAGER 212 Query: 536 PSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQ 595 G ++ F+TIL TRSYPHLRRVFQ++ K + +D+ + E+ GD+ + +V+ Sbjct: 213 RKGTDLNV---FITILTTRSYPHLRRVFQKYSKYSKHDMNKVLDLELKGDIENCLTVVVK 269 Query: 596 SVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEG 655 +KP+FFA+KL+++MKG GT KTL RIMVSRSEID+ +I+ + + Y SL QAI Sbjct: 270 CATSKPMFFAEKLHQAMKGIGTRHKTLIRIMVSRSEIDMNDIKACYQKLYGISLCQAILD 329 Query: 656 DTSGDFLKALLALCGGE 672 +T GD+ K L+ALCGG+ Sbjct: 330 ETKGDYEKILVALCGGD 346 >4MDV-A nrPDB Length = 375 Score = 223 bits (568), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 122/339 (35%), Positives = 198/339 (58%), Gaps = 22/339 (6%) Query: 6 QGAKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSL 65 G YR +I GF + DAE L+ +MKG G+++ AI++I+ R+N +RQE+CQSYKSL Sbjct: 22 HGKHYRPTIKPTTGFSASADAERLHRSMKGPGTNELAIINILARRTNYERQEICQSYKSL 81 Query: 66 YGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNE 125 Y +DL DLK + +G F +++ L+ Y AK + A+ G+GT+++ LIEI + N+ Sbjct: 82 YKQDLKDDLKSDTSGDFRKVLCQLIVDTPYMLAKSLYYAMKGLGTNDRVLIEIFTTLWND 141 Query: 126 QMHQLVAAYKDAY--------ERDLEADIIGDTSGHFQKMLVVLLQGTREE--------- 168 +M + AYK ER L D+ +T G ++ L+ L+Q R++ Sbjct: 142 EMKAVADAYKQVLKDKGSEESERSLVTDMKKETCGDYEYALLSLVQAERDDIPILQLKAI 201 Query: 169 -----DDVVSEDLVQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTG 223 + +++ +L + D +DLY +G + GT E + ++ NR+ L L + Y K G Sbjct: 202 PDKGVNSIINHELAEADAKDLYASGAGRVGTSERRITRVICNRTPYQLYLTSEIYFKMYG 261 Query: 224 KPIEASIRGELSGDFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSE 283 K + I E SGD+ KL++AV++ P AE L +M GLGT+D L+R++++RSE Sbjct: 262 KTLLEHIESETSGDYRKLLVAVLRYAIDRPSLIAEWLHDSMAGLGTKDYALMRLLITRSE 321 Query: 284 LDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKTLLKLSG 322 +D+ DI + + + Y KSL + +K+DTSG+Y++TL L G Sbjct: 322 IDLQDIMDAYESIYGKSLLNAVKDDTSGDYRRTLCVLMG 360 Score = 184 bits (466), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 113/336 (33%), Positives = 185/336 (55%), Gaps = 21/336 (6%) Query: 354 KGTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDL 413 + T++P F+ ADA+ L ++MKG GT+E II+I+ R+N +RQ+I Q++KS + +DL Sbjct: 27 RPTIKPTTGFSASADAERLHRSMKGPGTNELAIINILARRTNYERQEICQSYKSLYKQDL 86 Query: 414 MTDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAI 473 DLKS+ SGD +++ L++ + AK L AM+G GT+++ LIEI T N E++A+ Sbjct: 87 KDDLKSDTSGDFRKVLCQLIVDTPYMLAKSLYYAMKGLGTNDRVLIEIFTTLWNDEMKAV 146 Query: 474 NEAYK--------EDYHKSLEDALSSDTSGHFRRILISLATGHRE-----------EGGE 514 +AYK E+ +SL + +T G + L+SL R+ + G Sbjct: 147 ADAYKQVLKDKGSEESERSLVTDMKKETCGDYEYALLSLVQAERDDIPILQLKAIPDKGV 206 Query: 515 NLDQAREDAQVAAEILEIADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDV 574 N E A+ A+ ++ + +G + E R ++C R+ L + + KM + Sbjct: 207 NSIINHELAEADAK--DLYASGAGRVGTSERRITRVICNRTPYQLYLTSEIYFKMYGKTL 264 Query: 575 EHTIKKEMSGDVRDAFVAIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDL 634 I+ E SGD R VA+++ ++P A+ L+ SM G GT + L R++++RSEIDL Sbjct: 265 LEHIESETSGDYRKLLVAVLRYAIDRPSLIAEWLHDSMAGLGTKDYALMRLLITRSEIDL 324 Query: 635 LNIRREFIEKYDKSLHQAIEGDTSGDFLKALLALCG 670 +I + Y KSL A++ DTSGD+ + L L G Sbjct: 325 QDIMDAYESIYGKSLLNAVKDDTSGDYRRTLCVLMG 360 Score = 119 bits (297), Expect = 6e-27, Method: Compositional matrix adjust. Identities = 95/324 (29%), Positives = 160/324 (49%), Gaps = 30/324 (9%) Query: 193 GTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRST 252 GT+E I IL R+ + + Y + ++ ++ + SGDF K++ + I T Sbjct: 53 GTNELAIINILARRTNYERQEICQSYKSLYKQDLKDDLKSDTSGDFRKVL---CQLIVDT 109 Query: 253 PEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRT--------KYEKSLYSM 304 P A+ L+ AMKGLGT D LI I + +M + + ++ + E+SL + Sbjct: 110 PYMLAKSLYYAMKGLGTNDRVLIEIFTTLWNDEMKAVADAYKQVLKDKGSEESERSLVTD 169 Query: 305 IKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPANDFN 364 +K +T G+Y+ LL L + D P + +L A+ KG N Sbjct: 170 MKKETCGDYEYALLSLVQAERDD----IP--------ILQLKAIPD---KGVNSIINHEL 214 Query: 365 PDADAKALRKAMKG-LGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISG 423 +ADAK L + G +GT E I +I +R+ Q + + +G+ L+ ++SE SG Sbjct: 215 AEADAKDLYASGAGRVGTSERRITRVICNRTPYQLYLTSEIYFKMYGKTLLEHIESETSG 274 Query: 424 DLARLILGLM---MPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKED 480 D +L++ ++ + A+ L +M G GT + AL+ +L TR+ +++ I +AY+ Sbjct: 275 DYRKLLVAVLRYAIDRPSLIAEWLHDSMAGLGTKDYALMRLLITRSEIDLQDIMDAYESI 334 Query: 481 YHKSLEDALSSDTSGHFRRILISL 504 Y KSL +A+ DTSG +RR L L Sbjct: 335 YGKSLLNAVKDDTSGDYRRTLCVL 358 Score = 93.2 bits (230), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 92/378 (24%), Positives = 164/378 (43%), Gaps = 88/378 (23%) Query: 257 AERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKT 316 AERL ++MKG GT + +I I+ R+ + +I + +++ Y++ L +K+DTSG+++K Sbjct: 42 AERLHRSMKGPGTNELAIINILARRTNYERQEICQSYKSLYKQDLKDDLKSDTSGDFRKV 101 Query: 317 LLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPANDFNPDADAKALRKAM 376 L +L Y + AK+L AM Sbjct: 102 LCQL--------------IVDTPYML--------------------------AKSLYYAM 121 Query: 377 KGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFG--------RDLMTDLKSEISGDLARL 428 KGLGT++ +I+I T N + + + +K R L+TD+K E GD Sbjct: 122 KGLGTNDRVLIEIFTTLWNDEMKAVADAYKQVLKDKGSEESERSLVTDMKKETCGDYEYA 181 Query: 429 ILGLM--------------MPP-----------AHYDAKQLKKAMEG-AGTDEKALIEIL 462 +L L+ +P A DAK L + G GT E+ + ++ Sbjct: 182 LLSLVQAERDDIPILQLKAIPDKGVNSIINHELAEADAKDLYASGAGRVGTSERRITRVI 241 Query: 463 ATRTNAEIRAINEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQARED 522 RT ++ +E Y + Y K+L + + S+TSG +R++L+++ L A + Sbjct: 242 CNRTPYQLYLTSEIYFKMYGKTLLEHIESETSGDYRKLLVAV-----------LRYAIDR 290 Query: 523 AQVAAEILEIADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEM 582 + AE L D+ +G T + M +L TRS L+ + + + + + +K + Sbjct: 291 PSLIAEWLH--DSMAGLGTK-DYALMRLLITRSEIDLQDIMDAYESIYGKSLLNAVKDDT 347 Query: 583 SGDVRDAFVAIVQSVKNK 600 SGD R ++ + N+ Sbjct: 348 SGDYRRTLCVLMGEIYNQ 365 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 34/137 (24%), Positives = 64/137 (46%), Gaps = 11/137 (8%) Query: 544 ETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNKPLF 603 E + IL R+ + + Q + + D++ +K + SGD R + Q + + P Sbjct: 56 ELAIINILARRTNYERQEICQSYKSLYKQDLKDDLKSDTSGDFRKV---LCQLIVDTPYM 112 Query: 604 FADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREF--------IEKYDKSLHQAIEG 655 A LY +MKG GT+++ L I + ++ + + E+ ++SL ++ Sbjct: 113 LAKSLYYAMKGLGTNDRVLIEIFTTLWNDEMKAVADAYKQVLKDKGSEESERSLVTDMKK 172 Query: 656 DTSGDFLKALLALCGGE 672 +T GD+ ALL+L E Sbjct: 173 ETCGDYEYALLSLVQAE 189 >1YCN-A nrPDB Length = 317 Score = 176 bits (447), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 112/314 (35%), Positives = 170/314 (54%), Gaps = 15/314 (4%) Query: 365 PDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGD 424 P DA+ LR A +G GT+ED II I+ HRS QR+ IRQ + +G DL+ L E+S D Sbjct: 13 PSDDAEQLRTAFEGWGTNEDLIISILAHRSAEQRKVIRQAYHETYGEDLLKTLDKELSND 72 Query: 425 LARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKS 484 R IL + P DA +A + + + L+E+ TRT+ ++ +AY Y KS Sbjct: 73 FERAILLWTLEPGERDALLANEATKRWTSSNQVLMEVACTRTSTQLLHARQAYHARYKKS 132 Query: 485 LEDALSSDTSGHFRRILISLATGHREEGGE-NLDQAREDAQVAAEILEIADTPSGDKTSL 543 LE+ ++ T+G FR++L+SL T +R EG E N+ A+++A++ E ++ DK Sbjct: 133 LEEDVAHHTTGDFRKLLVSLVTSYRYEGDEVNMTLAKQEAKLVHEKIK-------DKHYN 185 Query: 544 ETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAI----VQSVKN 599 + + IL TRS + F + + E +K GD D F+A+ +Q + Sbjct: 186 DEDVIRILSTRSKAQINATFNRY---QDDHGEEILKSLEEGDDDDKFLALLRSTIQCLTR 242 Query: 600 KPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSG 659 L+F D L ++ GTDE LTRI+ +R+EIDL I E+ + L +AI DT G Sbjct: 243 PELYFVDVLRSAINKTGTDEGALTRIVTTRAEIDLKVIGEEYQRRNSIPLEKAITKDTRG 302 Query: 660 DFLKALLALCGGED 673 D+ K L+AL G +D Sbjct: 303 DYEKMLVALLGEDD 316 Score = 158 bits (399), Expect = 8e-39, Method: Compositional matrix adjust. Identities = 101/305 (33%), Positives = 163/305 (53%), Gaps = 2/305 (0%) Query: 22 PNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIADLKYELTGK 81 P+ DAE L TA +G+G++++ I+ I+ RS QR+ + Q+Y YG+DL+ L EL+ Sbjct: 13 PSDDAEQLRTAFEGWGTNEDLIISILAHRSAEQRKVIRQAYHETYGEDLLKTLDKELSND 72 Query: 82 FERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVAAYKDAYERD 141 FER I+ P DA +A + + L+E+ +RT+ Q+ AY Y++ Sbjct: 73 FERAILLWTLEPGERDALLANEATKRWTSSNQVLMEVACTRTSTQLLHARQAYHARYKKS 132 Query: 142 LEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELKWGTDEAQFIY 201 LE D+ T+G F+K+LV L+ R E D V+ L +Q+ + ++E + K DE I Sbjct: 133 LEEDVAHHTTGDFRKLLVSLVTSYRYEGDEVNMTLAKQEAKLVHEKIKDKHYNDE-DVIR 191 Query: 202 ILGNRSKQHLRLVFDEYLKTTGKPIEASI-RGELSGDFEKLMLAVVKCIRSTPEYFAERL 260 IL RSK + F+ Y G+ I S+ G+ F L+ + ++C+ YF + L Sbjct: 192 ILSTRSKAQINATFNRYQDDHGEEILKSLEEGDDDDKFLALLRSTIQCLTRPELYFVDVL 251 Query: 261 FKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKTLLKL 320 A+ GT + L RI+ +R+E+D+ I E ++ + L I DT G+Y+K L+ L Sbjct: 252 RSAINKTGTDEGALTRIVTTRAEIDLKVIGEEYQRRNSIPLEKAITKDTRGDYEKMLVAL 311 Query: 321 SGGDD 325 G DD Sbjct: 312 LGEDD 316 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 63/243 (25%), Positives = 107/243 (44%), Gaps = 30/243 (12%) Query: 434 MPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKSLEDALSSDT 493 +P DA+QL+ A EG GT+E +I ILA R+ + + I +AY E Y + L L + Sbjct: 10 VPAPSDDAEQLRTAFEGWGTNEDLIISILAHRSAEQRKVIRQAYHETYGEDLLKTLDKEL 69 Query: 494 SGHFRR--ILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDKTSLETRFMTIL 551 S F R +L +L G R DA +A E + TS M + Sbjct: 70 SNDFERAILLWTLEPGER------------DALLANE-------ATKRWTSSNQVLMEVA 110 Query: 552 CTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVK------NKPLFF- 604 CTR+ L Q + +E + +GD R V++V S + N L Sbjct: 111 CTRTSTQLLHARQAYHARYKKSLEEDVAHHTTGDFRKLLVSLVTSYRYEGDEVNMTLAKQ 170 Query: 605 -ADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAI-EGDTSGDFL 662 A +++ +K +++ + RI+ +RS+ + + + + + + +++ EGD FL Sbjct: 171 EAKLVHEKIKDKHYNDEDVIRILSTRSKAQINATFNRYQDDHGEEILKSLEEGDDDDKFL 230 Query: 663 KAL 665 L Sbjct: 231 ALL 233 >3BRX-A nrPDB Length = 317 Score = 155 bits (391), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 101/309 (32%), Positives = 164/309 (53%), Gaps = 18/309 (5%) Query: 368 DAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLAR 427 D + LRKA G GT+E IIDI+ HR+ QR IR+T+ +G DL+ L E+S D R Sbjct: 17 DCEQLRKAFSGWGTNEGLIIDILGHRNAEQRNLIRKTYAETYGEDLLKALDKELSNDFER 76 Query: 428 LILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKSLED 487 L+L + PA DA +A + + + L+EI TR+ ++ +AY Y KSLE+ Sbjct: 77 LVLLWALDPAERDALLANEATKRWTSSNQVLMEIACTRSANQLLHARQAYHARYKKSLEE 136 Query: 488 ALSSDTSGHFRRILISLATGHREEGGE-NLDQAREDAQVAAEILEIADTPSGDKTSLETR 546 ++ T+G F ++L+ L + +R EG E N+ A+ +A++ E + +K + Sbjct: 137 DVAHHTTGDFHKLLLPLVSSYRYEGEEVNMTLAKTEAKLLHEKI-------SNKAYSDDD 189 Query: 547 FMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNKPLFFAD 606 + +L TRS + + D I K++ D +D F+A+++S K L + + Sbjct: 190 VIRVLATRSKAQINATLNHYKNEYGND----INKDLKADPKDEFLALLRSTV-KCLVYPE 244 Query: 607 KLYK-----SMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGDF 661 K ++ ++ GTDE LTR++ +R+E+DL I E+ + L +AI DT GD+ Sbjct: 245 KYFEKVLRLAINRRGTDEGALTRVVCTRAEVDLKVIADEYQRRNSVPLTRAIVKDTHGDY 304 Query: 662 LKALLALCG 670 K LL L G Sbjct: 305 EKLLLVLAG 313 Score = 143 bits (360), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 90/300 (30%), Positives = 156/300 (52%), Gaps = 1/300 (0%) Query: 23 NQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIADLKYELTGKF 82 ++D E L A G+G+++ I+DI+ R+ QR + ++Y YG+DL+ L EL+ F Sbjct: 15 SEDCEQLRKAFSGWGTNEGLIIDILGHRNAEQRNLIRKTYAETYGEDLLKALDKELSNDF 74 Query: 83 ERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVAAYKDAYERDL 142 ERL++ PA DA +A + + L+EI +R+ Q+ AY Y++ L Sbjct: 75 ERLVLLWALDPAERDALLANEATKRWTSSNQVLMEIACTRSANQLLHARQAYHARYKKSL 134 Query: 143 EADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELKWGTDEAQFIYI 202 E D+ T+G F K+L+ L+ R E + V+ L + + + L+E K +D+ I + Sbjct: 135 EEDVAHHTTGDFHKLLLPLVSSYRYEGEEVNMTLAKTEAKLLHEKISNKAYSDD-DVIRV 193 Query: 203 LGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRSTPEYFAERLFK 262 L RSK + + Y G I ++ + +F L+ + VKC+ +YF + L Sbjct: 194 LATRSKAQINATLNHYKNEYGNDINKDLKADPKDEFLALLRSTVKCLVYPEKYFEKVLRL 253 Query: 263 AMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKTLLKLSG 322 A+ GT + L R++ +R+E+D+ I + ++ + L I DT G+Y+K LL L+G Sbjct: 254 AINRRGTDEGALTRVVCTRAEVDLKVIADEYQRRNSVPLTRAIVKDTHGDYEKLLLVLAG 313 Score = 67.0 bits (162), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 61/248 (24%), Positives = 102/248 (41%), Gaps = 25/248 (10%) Query: 426 ARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKSL 485 A L + +P D +QL+KA G GT+E +I+IL R + I + Y E Y + L Sbjct: 3 ATLTVPTTVPSVSEDCEQLRKAFSGWGTNEGLIIDILGHRNAEQRNLIRKTYAETYGEDL 62 Query: 486 EDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDKTSLET 545 AL + S F R+++ A LD A DA +A E + TS Sbjct: 63 LKALDKELSNDFERLVLLWA----------LDPAERDALLANE-------ATKRWTSSNQ 105 Query: 546 RFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVK------N 599 M I CTRS L Q + +E + +GD + +V S + N Sbjct: 106 VLMEIACTRSANQLLHARQAYHARYKKSLEEDVAHHTTGDFHKLLLPLVSSYRYEGEEVN 165 Query: 600 KPLFF--ADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDT 657 L A L++ + + + R++ +RS+ + + +Y +++ ++ D Sbjct: 166 MTLAKTEAKLLHEKISNKAYSDDDVIRVLATRSKAQINATLNHYKNEYGNDINKDLKADP 225 Query: 658 SGDFLKAL 665 +FL L Sbjct: 226 KDEFLALL 233 Score = 62.4 bits (150), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 75/356 (21%), Positives = 135/356 (37%), Gaps = 69/356 (19%) Query: 257 AERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKT 316 E+L KA G GT + +I I+ R+ IR+ + Y + L + + S ++++ Sbjct: 18 CEQLRKAFSGWGTNEGLIIDILGHRNAEQRNLIRKTYAETYGEDLLKALDKELSNDFERL 77 Query: 317 LLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPANDFNPDADAKALRKAM 376 +L +W L R DA +A Sbjct: 78 VL-----------------------LWALDPAER-----------------DALLANEAT 97 Query: 377 KGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARLILGLM--- 433 K + +++I RS Q RQ + + + + L D+ +GD +L+L L+ Sbjct: 98 KRWTSSNQVLMEIACTRSANQLLHARQAYHARYKKSLEEDVAHHTTGDFHKLLLPLVSSY 157 Query: 434 --------MPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKSL 485 M A +AK L + + + +I +LATR+ A+I A YK +Y + Sbjct: 158 RYEGEEVNMTLAKTEAKLLHEKISNKAYSDDDVIRVLATRSKAQINATLNHYKNEYGNDI 217 Query: 486 EDALSSDTSGHFRRILISLATG--HREEGGENLDQAREDAQVAAEILEIADTPSGDKTSL 543 L +D F +L S + E+ E ++L +A G Sbjct: 218 NKDLKADPKDEFLALLRSTVKCLVYPEKYFE-------------KVLRLAINRRGTDEGA 264 Query: 544 ETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKN 599 TR ++CTR+ L+ + E+ + + + I K+ GD + + V+N Sbjct: 265 LTR---VVCTRAEVDLKVIADEYQRRNSVPLTRAIVKDTHGDYEKLLLVLAGHVEN 317 >1DK5-A nrPDB Length = 322 Score = 148 bits (373), Expect = 9e-36, Method: Compositional matrix adjust. Identities = 103/321 (32%), Positives = 168/321 (52%), Gaps = 20/321 (6%) Query: 359 PANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLK 418 PA+ + D + LR A KG GT+E II I+ HR+ QR+ IRQT+ FG DL+ +L Sbjct: 15 PAHVPSAAEDCEQLRSAFKGWGTNEKLIISILAHRTAAQRKLIRQTYAETFGEDLLKELD 74 Query: 419 SEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYK 478 E++ D +L+L + P+ DA K+A + L+E+ TR+ E+ EAY Sbjct: 75 RELTHDFEKLVLVWTLDPSERDAHLAKEATKRWTKSNFVLVELACTRSPKELVLAREAYH 134 Query: 479 EDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLD--QAREDAQVAAEILEIADTP 536 Y KSLE+ ++ T+G R++L+ L + +R GGE +D A+ ++++ E + Sbjct: 135 ARYKKSLEEDVAYHTTGDHRKLLVPLVSSYR-YGGEEVDLRLAKAESKILHEKI------ 187 Query: 537 SGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQS 596 DK + + IL TRS L + D+ +K+ G D FVA++++ Sbjct: 188 -SDKAYSDDEVIRILATRSKAQLNATLNHYKDEHGEDI---LKQLEDG---DEFVALLRA 240 Query: 597 VKNKPL----FFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQA 652 + +F + L ++ GT+E LTR++ +R+E+DL I E+ ++ L +A Sbjct: 241 TIKGLVYPEHYFVEVLRDAINRRGTEEDHLTRVIATRAEVDLKIIADEYQKRDSIPLGRA 300 Query: 653 IEGDTSGDFLKALLALCGGED 673 I DT GD+ LLAL G E+ Sbjct: 301 IAKDTRGDYESMLLALLGQEE 321 Score = 130 bits (326), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 92/311 (29%), Positives = 161/311 (51%), Gaps = 5/311 (1%) Query: 18 PGFDPN--QDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIADLK 75 P P+ +D E L +A KG+G++++ I+ I+ R+ QR+ + Q+Y +G+DL+ +L Sbjct: 15 PAHVPSAAEDCEQLRSAFKGWGTNEKLIISILAHRTAAQRKLIRQTYAETFGEDLLKELD 74 Query: 76 YELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVAAYK 135 ELT FE+L++ P+ DA K+A L+E+ +R+ +++ AY Sbjct: 75 RELTHDFEKLVLVWTLDPSERDAHLAKEATKRWTKSNFVLVELACTRSPKELVLAREAYH 134 Query: 136 DAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELKWGTD 195 Y++ LE D+ T+G +K+LV L+ R + V L + + + L+E K +D Sbjct: 135 ARYKKSLEEDVAYHTTGDHRKLLVPLVSSYRYGGEEVDLRLAKAESKILHEKISDKAYSD 194 Query: 196 EAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRSTPEY 255 + + I IL RSK L + Y G+ I + E +F L+ A +K + Y Sbjct: 195 D-EVIRILATRSKAQLNATLNHYKDEHGEDILKQL--EDGDEFVALLRATIKGLVYPEHY 251 Query: 256 FAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKK 315 F E L A+ GT ++ L R++ +R+E+D+ I + ++ + L I DT G+Y+ Sbjct: 252 FVEVLRDAINRRGTEEDHLTRVIATRAEVDLKIIADEYQKRDSIPLGRAIAKDTRGDYES 311 Query: 316 TLLKLSGGDDD 326 LL L G ++D Sbjct: 312 MLLALLGQEED 322 Score = 76.6 bits (187), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 83/358 (23%), Positives = 143/358 (39%), Gaps = 61/358 (17%) Query: 85 LIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVAAYKDAYERDLEA 144 L V P A D ++++ A G GT+EK +I ILA RT Q + Y + + DL Sbjct: 12 LTVPAHVPSAAEDCEQLRSAFKGWGTNEKLIISILAHRTAAQRKLIRQTYAETFGEDLLK 71 Query: 145 DIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELKWGTDEAQFIYILG 204 ++ + + F+K+++V E D ++++ + +W + + Sbjct: 72 ELDRELTHDFEKLVLVWTLDPSERDAHLAKEATK------------RWTKSNFVLVELAC 119 Query: 205 NRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRSTPEYFAERLFKAM 264 RS + L L + Y K +E + +GD KL++ +V R E RL KA Sbjct: 120 TRSPKELVLAREAYHARYKKSLEEDVAYHTTGDHRKLLVPLVSSYRYGGEEVDLRLAKAE 179 Query: 265 KGL--------GTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKT 316 + D+ +IRI+ +RS K+ + N E+ + Sbjct: 180 SKILHEKISDKAYSDDEVIRILATRS----------------KAQLNATLNHYKDEHGED 223 Query: 317 LLK-LSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPANDFNPDADAKALRKA 375 +LK L GD E A+ R +KG V P + F + LR A Sbjct: 224 ILKQLEDGD-------------------EFVALLRATIKGLVYPEHYF-----VEVLRDA 259 Query: 376 MKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARLILGLM 433 + GT+ED + +I R+ V + I ++ L + + GD ++L L+ Sbjct: 260 INRRGTEEDHLTRVIATRAEVDLKIIADEYQKRDSIPLGRAIAKDTRGDYESMLLALL 317 Score = 57.4 bits (137), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 46/174 (26%), Positives = 78/174 (44%), Gaps = 17/174 (9%) Query: 425 LARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKS 484 +A L + +P A D +QL+ A +G GT+EK +I ILA RT A+ + I + Y E + + Sbjct: 9 MASLTVPAHVPSAAEDCEQLRSAFKGWGTNEKLIISILAHRTAAQRKLIRQTYAETFGED 68 Query: 485 LEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDKTSLE 544 L L + + F ++++ LD + DA +A E T K++ Sbjct: 69 LLKELDRELTHDFEKLVLVW----------TLDPSERDAHLAKEA-----TKRWTKSNF- 112 Query: 545 TRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVK 598 + + CTRS L + + +E + +GD R V +V S + Sbjct: 113 -VLVELACTRSPKELVLAREAYHARYKKSLEEDVAYHTTGDHRKLLVPLVSSYR 165 >1BO9-A nrPDB Length = 73 Score = 66.2 bits (160), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 32/71 (45%), Positives = 44/71 (61%) Query: 363 FNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEIS 422 FNP +D AL KA+ G DE TIIDI+T R+N QRQQI+ + G+ L LK ++ Sbjct: 2 FNPSSDVAALHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALT 61 Query: 423 GDLARLILGLM 433 G L ++L L+ Sbjct: 62 GHLEEVVLALL 72 Score = 58.9 bits (141), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 28/72 (38%), Positives = 44/72 (61%) Query: 20 FDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIADLKYELT 79 F+P+ D AL+ A+ G D+ I+DI+T R+N QRQ++ +Y GK L LK LT Sbjct: 2 FNPSSDVAALHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALT 61 Query: 80 GKFERLIVGLMR 91 G E +++ L++ Sbjct: 62 GHLEEVVLALLK 73 Score = 45.4 bits (106), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 25/68 (36%), Positives = 43/68 (63%), Gaps = 1/68 (1%) Query: 180 DVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFE 239 DV L++A +K G DEA I IL R+ + + YL+ TGKP++ +++ L+G E Sbjct: 7 DVAALHKAIMVK-GVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLE 65 Query: 240 KLMLAVVK 247 +++LA++K Sbjct: 66 EVVLALLK 73 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 22/65 (33%), Positives = 36/65 (55%) Query: 440 DAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKSLEDALSSDTSGHFRR 499 D L KA+ G DE +I+IL R NA+ + I AY ++ K L++ L +GH Sbjct: 7 DVAALHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLEE 66 Query: 500 ILISL 504 ++++L Sbjct: 67 VVLAL 71 Score = 38.5 bits (88), Expect = 0.009, Method: Compositional matrix adjust. Identities = 21/68 (30%), Positives = 35/68 (51%) Query: 96 CDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQ 155 D + AI G DE +I+IL R N Q Q+ AAY + L+ + +GH + Sbjct: 6 SDVAALHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLE 65 Query: 156 KMLVVLLQ 163 ++++ LL+ Sbjct: 66 EVVLALLK 73 Score = 28.5 bits (62), Expect = 9.3, Method: Compositional matrix adjust. Identities = 15/61 (24%), Positives = 32/61 (52%) Query: 608 LYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGDFLKALLA 667 L+K++ G DE T+ I+ R+ I+ ++++ K L + ++ +G + +LA Sbjct: 11 LHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLA 70 Query: 668 L 668 L Sbjct: 71 L 71 >3CHK-A nrPDB Length = 337 Score = 65.1 bits (157), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 61/243 (25%), Positives = 111/243 (45%), Gaps = 9/243 (3%) Query: 386 IIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARLILGLMMPPAHYDAKQLK 445 +I+I Q + +++TF++ G L LK +S D L+L L P A + ++ Sbjct: 32 LIEIARSYPPNQLRNMQRTFQAITGTFLDAFLKKHLSKDFESLVLMLYKPRAQLLCELIR 91 Query: 446 KAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKSLEDALSSDTSGHFR--RILIS 503 A +GAGTDEK L+++L T E+R I + Y + Y+ SL D + D + +++ + Sbjct: 92 GATKGAGTDEKCLVDVLLTIETHEVREIRQLYYQLYNDSLGDVVRKDCGDKYMWAKLINA 151 Query: 504 LATGHREEGGENLDQAREDAQVAAEILEIADTPSGDKTSLETRFMTILCTRSYPHLRRVF 563 +ATG R + + ED + + +E G K + ++ I T + R++ Sbjct: 152 VATGDRIP--RDTHELEEDLVLVRKAIET----KGVKKDEVSTWIRIFATYTRADFRQLH 205 Query: 564 QEFIKMTNYD-VEHTIKKEMSGDVRDAFVAIVQSVKNKPLFFADKLYKSMKGAGTDEKTL 622 + + N D + ++ E G AF + + A + + G+G+D L Sbjct: 206 KMYSAKYNGDSLRAGVEDEFQGLDEYAFKLAHDFLYDPCCAAAFSMNVAFAGSGSDSNRL 265 Query: 623 TRI 625 RI Sbjct: 266 NRI 268 Score = 54.3 bits (129), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 53/201 (26%), Positives = 94/201 (46%), Gaps = 12/201 (5%) Query: 43 ILDIITSRSNRQRQEVCQSYKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIK 102 +++I S Q + + ++++++ G L A LK L+ FE L++ L +P A + I+ Sbjct: 32 LIEIARSYPPNQLRNMQRTFQAITGTFLDAFLKKHLSKDFESLVLMLYKPRAQLLCELIR 91 Query: 103 DAISGIGTDEKCLIEILASRTNEQMHQLVAAYKDAYERDLEADIIGDTSG---HFQKMLV 159 A G GTDEKCL+++L + ++ ++ Y Y L D++ G + K++ Sbjct: 92 GATKGAGTDEKCLVDVLLTIETHEVREIRQLYYQLYNDSL-GDVVRKDCGDKYMWAKLIN 150 Query: 160 VLLQGTREEDDV--VSEDLVQQDVQDLYEAGELKWGTDE-AQFIYILGNRSKQHLRLVFD 216 + G R D + EDLV V+ E +K DE + +I I ++ R + Sbjct: 151 AVATGDRIPRDTHELEEDLVL--VRKAIETKGVK--KDEVSTWIRIFATYTRADFRQLHK 206 Query: 217 EY-LKTTGKPIEASIRGELSG 236 Y K G + A + E G Sbjct: 207 MYSAKYNGDSLRAGVEDEFQG 227 Score = 53.5 bits (127), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 64/285 (22%), Positives = 120/285 (42%), Gaps = 45/285 (15%) Query: 222 TGKPIEASIRGELSGDFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSR 281 TG ++A ++ LS DFE L+L + K + E + A KG GT + L+ ++++ Sbjct: 55 TGTFLDAFLKKHLSKDFESLVLMLYK---PRAQLLCELIRGATKGAGTDEKCLVDVLLTI 111 Query: 282 SELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQ 341 ++ +IR+++ Y SL +++ D +Y Sbjct: 112 ETHEVREIRQLYYQLYNDSLGDVVRKDCGDKY---------------------------- 143 Query: 342 MWE--LSAVARVELKGTVRPANDFNPDADAKALRKAM--KGLGTDE-DTIIDIITHRSNV 396 MW ++AVA G P + + D +RKA+ KG+ DE T I I + Sbjct: 144 MWAKLINAVA----TGDRIPRDTHELEEDLVLVRKAIETKGVKKDEVSTWIRIFATYTRA 199 Query: 397 QRQQIRQTFKSHF-GRDLMTDLKSEISG--DLA-RLILGLMMPPAHYDAKQLKKAMEGAG 452 +Q+ + + + + G L ++ E G + A +L + P A + A G+G Sbjct: 200 DFRQLHKMYSAKYNGDSLRAGVEDEFQGLDEYAFKLAHDFLYDPCCAAAFSMNVAFAGSG 259 Query: 453 TDEKALIEILATRTNAEIRAINEAYKEDYHKSLEDALSSDTSGHF 497 +D L I A E + YK+ Y ++ ++ +++ G + Sbjct: 260 SDSNRLNRITAMHFR-ECKGCKYYYKKVYGQAFDERCATELKGVY 303 Score = 43.5 bits (101), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 30/115 (26%), Positives = 56/115 (48%), Gaps = 5/115 (4%) Query: 554 RSYP--HLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNKPLFFADKLYKS 611 RSYP LR + + F +T ++ +KK +S D ++ K + + + + Sbjct: 37 RSYPPNQLRNMQRTFQAITGTFLDAFLKKHLSKDFESL---VLMLYKPRAQLLCELIRGA 93 Query: 612 MKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGDFLKALL 666 KGAGTDEK L ++++ ++ IR+ + + Y+ SL + D ++ A L Sbjct: 94 TKGAGTDEKCLVDVLLTIETHEVREIRQLYYQLYNDSLGDVVRKDCGDKYMWAKL 148 Score = 28.5 bits (62), Expect = 8.8, Method: Compositional matrix adjust. Identities = 33/130 (25%), Positives = 54/130 (41%), Gaps = 15/130 (11%) Query: 26 AEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIADL-------KYEL 78 E + A KG G+D++ ++D++ + + +E+ Q Y LY D + D+ KY Sbjct: 87 CELIRGATKGAGTDEKCLVDVLLTIETHEVREIRQLYYQLYN-DSLGDVVRKDCGDKYMW 145 Query: 79 TGKFERLIVGLMRPPAYCDAKE----IKDAI--SGIGTDE-KCLIEILASRTNEQMHQLV 131 + G P + +E ++ AI G+ DE I I A+ T QL Sbjct: 146 AKLINAVATGDRIPRDTHELEEDLVLVRKAIETKGVKKDEVSTWIRIFATYTRADFRQLH 205 Query: 132 AAYKDAYERD 141 Y Y D Sbjct: 206 KMYSAKYNGD 215 >4EVF-A nrPDB Length = 295 Score = 49.7 bits (117), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 49/195 (25%), Positives = 86/195 (44%), Gaps = 7/195 (3%) Query: 37 GSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIADLKYELTGKFER-LIVGLMRPPAY 95 D+ I I + S R+++ ++Y + YGK+L D+K L G E L++ L Sbjct: 17 AKDEVQIAFIASEYSAESREKIAKAYVASYGKELPDDIKKALKGGSEESLLMDLFSDRHE 76 Query: 96 CDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQ 155 A+ I+DA+SG D + + T E H+ VAAY +++ L D + D + Sbjct: 77 VRAQHIRDALSG-RNDHMAFFDTVILCTPEDWHETVAAYTRMFKKPLVEDFMKDVGR--K 133 Query: 156 KMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVF 215 + +L++ + V + + Q L +A + K + A I G R + Sbjct: 134 EDWCLLMEKWMAHERVSRPGSPEDEAQRLDQAFDQK---NTAYLIDFFGTVPSAEYRPIA 190 Query: 216 DEYLKTTGKPIEASI 230 + + GK IE +I Sbjct: 191 EAFKAQNGKSIEQAI 205 Score = 34.3 bits (77), Expect = 0.17, Method: Compositional matrix adjust. Identities = 50/195 (25%), Positives = 81/195 (41%), Gaps = 49/195 (25%) Query: 337 QVAYQMWELSAVARVEL-KGTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSN 395 Q+A+ E SA +R ++ K V PD ++KA+KG G++E ++D+ + R Sbjct: 22 QIAFIASEYSAESREKIAKAYVASYGKELPDD----IKKALKG-GSEESLLMDLFSDRHE 76 Query: 396 VQRQQIR--------------------------------QTFKSHFGRDLMTDLKSEISG 423 V+ Q IR + FK D M D+ + Sbjct: 77 VRAQHIRDALSGRNDHMAFFDTVILCTPEDWHETVAAYTRMFKKPLVEDFMKDVGRK--E 134 Query: 424 DLARLILGLMM------PPAHYD-AKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEA 476 D L+ M P + D A++L +A + T LI+ T +AE R I EA Sbjct: 135 DWCLLMEKWMAHERVSRPGSPEDEAQRLDQAFDQKNT--AYLIDFFGTVPSAEYRPIAEA 192 Query: 477 YKEDYHKSLEDALSS 491 +K KS+E A+++ Sbjct: 193 FKAQNGKSIEQAIAT 207 >2IIC-A nrPDB Length = 310 Score = 37.0 bits (84), Expect = 0.030, Method: Compositional matrix adjust. Identities = 36/139 (25%), Positives = 65/139 (46%), Gaps = 10/139 (7%) Query: 362 DFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEI 421 D N A ++KAMK + D I D++ + +R ++ Q +K G DL+ D +I Sbjct: 74 DCNISARVNVIKKAMKNVN-DFRAIHDVVLIATPDERLKLAQAYKEKTGNDLLQDFVDQI 132 Query: 422 -----SGDLARLILGLMMPP---AHYDAKQLKKAMEGAG-TDEKALIEILATRTNAEIRA 472 + L L + P DA+ LK + A D +A++ ++ T T E + Sbjct: 133 PLTSAASYLCHLAIRENRTPRGSVASDAEVLKHNLIDADEPDHEAVVRLIITSTADEYKE 192 Query: 473 INEAYKEDYHKSLEDALSS 491 IN ++ KS+++A+ + Sbjct: 193 INHRFEVLTGKSVQEAIET 211 >3J8C-K nrPDB Length = 208 Score = 30.8 bits (68), Expect = 2.0, Method: Compositional matrix adjust. Identities = 26/110 (23%), Positives = 48/110 (43%), Gaps = 17/110 (15%) Query: 243 LAVVKCIRSTPEYF-----AERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREI----- 292 LAV+K + P +F A+ L KA+ L D TL + M+ ++ + IR+I Sbjct: 48 LAVLKLYQFNPAFFQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGD 107 Query: 293 -FRTKYEKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQ 341 T + ++ + + + LL+ G +D+ +F + YQ Sbjct: 108 LLETCHFQAFWQALDENMD------LLEGITGFEDSVRKFICHVVGITYQ 151 >6FEC-6 nrPDB Length = 218 Score = 30.8 bits (68), Expect = 2.1, Method: Compositional matrix adjust. Identities = 26/110 (23%), Positives = 48/110 (43%), Gaps = 17/110 (15%) Query: 243 LAVVKCIRSTPEYF-----AERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREI----- 292 LAV+K + P +F A+ L KA+ L D TL + M+ ++ + IR+I Sbjct: 48 LAVLKLYQFNPAFFQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGD 107 Query: 293 -FRTKYEKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQ 341 T + ++ + + + LL+ G +D+ +F + YQ Sbjct: 108 LLETCHFQAFWQALDENMD------LLEGITGFEDSVRKFICHVVGITYQ 151 >5FL3-A nrPDB Length = 368 Score = 30.4 bits (67), Expect = 2.7, Method: Compositional matrix adjust. Identities = 15/24 (62%), Positives = 19/24 (79%) Query: 484 SLEDALSSDTSGHFRRILISLATG 507 SLEDALS+ TS H R+L++ ATG Sbjct: 342 SLEDALSAATSPHEFRLLLTKATG 365 >4AQ4-A nrPDB Length = 419 Score = 29.3 bits (64), Expect = 5.3, Method: Compositional matrix adjust. Identities = 23/87 (26%), Positives = 44/87 (50%), Gaps = 8/87 (9%) Query: 116 IEILASRTNEQM--HQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVS 173 ++ LA R N + +++V YK YE++L A I +G+ +L V GT + Sbjct: 22 VDSLAQRFNAENPDYKIVPTYKGNYEQNLSAGIAAFRTGNAPAILQVYEVGTA----TMM 77 Query: 174 EDLVQQDVQDLYEAGELKWGTDEAQFI 200 + V D+++ +++ DE+QF+ Sbjct: 78 ASKAIKPVYDVFKEAGIQF--DESQFV 102 >4FXY-P nrPDB Length = 693 Score = 28.9 bits (63), Expect = 8.3, Method: Compositional matrix adjust. Identities = 29/118 (24%), Positives = 50/118 (42%), Gaps = 6/118 (5%) Query: 559 LRRVFQEFIKMTNYDVEHTIKKEMSG-DVRDAFVAIVQSVKNKPLFFADKLYKSMK---- 613 +R F EF + + T SG +V FV + + ++ D L K K Sbjct: 481 VRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDVDSLRKLSKHYKD 540 Query: 614 GAGTDEKTLTRIMVSR-SEIDLLNIRREFIEKYDKSLHQAIEGDTSGDFLKALLALCG 670 G ++ L +++ SR LL +R+ + K D+SLH D + ++ K + G Sbjct: 541 GHPITDELLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNATLDAASEYAKYCTEILG 598 >2O36-A nrPDB Length = 674 Score = 28.5 bits (62), Expect = 9.6, Method: Compositional matrix adjust. Identities = 16/74 (21%), Positives = 38/74 (51%), Gaps = 3/74 (4%) Query: 598 KNKPLFFADKLYKSMKGAGTDEKTLTRIMVSR-SEIDLLNIRREFIEKYDKSLHQAIEGD 656 + +PL + Y++ G+ + L +++ SR + L N+R+ + K D++LH + D Sbjct: 499 EQEPLLRMSRHYRT--GSAVPRELLEKLIESRQANTGLFNLRQIVLAKVDQALHTQTDAD 556 Query: 657 TSGDFLKALLALCG 670 + ++ + + G Sbjct: 557 PAEEYARLCQEILG 570 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1M9I-A nrPDB 934 0.0 1AVC-A nrPDB 915 0.0 2ZHI-A nrPDB 447 e-126 2ZOC-A nrPDB 443 e-124 1I4A-A nrPDB 436 e-122 1YII-A nrPDB 431 e-121 1SAV-A nrPDB 429 e-120 2IE7-A nrPDB 427 e-119 1AII-A nrPDB 420 e-118 5N7D-A nrPDB 410 e-115 1HM6-A nrPDB 404 e-113 1AIN-A nrPDB 404 e-113 1W3W-A nrPDB 404 e-113 4X9P-A nrPDB 395 e-110 1DM5-A nrPDB 393 e-109 6B3I-A nrPDB 381 e-106 4MDV-A nrPDB 365 e-101 3BRX-A nrPDB 352 2e-97 1YCN-A nrPDB 340 8e-94 1DK5-A nrPDB 333 1e-91 3CHK-A nrPDB 234 7e-62 4EVF-A nrPDB 180 2e-45 1BO9-A nrPDB 99 5e-21 Sequences not found previously or not previously below threshold: 2IIC-A nrPDB 68 1e-11 6HIW-DG nrPDB 32 1.0 3IYJ-F nrPDB 30 4.3 1IHU-A nrPDB 29 5.3 2ZQJ-A nrPDB 29 5.4 3AMU-A nrPDB 29 6.5 3AU7-A nrPDB 29 6.7 5V8F-D nrPDB 28 9.4 >1M9I-A nrPDB Length = 672 Score = 934 bits (2413), Expect = 0.0, Method: Composition-based stats. Identities = 670/672 (99%), Positives = 671/672 (99%) Query: 2 AKPAQGAKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQS 61 AKPAQGAKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQS Sbjct: 1 AKPAQGAKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQS 60 Query: 62 YKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILAS 121 YKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILAS Sbjct: 61 YKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILAS 120 Query: 122 RTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDV 181 RTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDV Sbjct: 121 RTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDV 180 Query: 182 QDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKL 241 QDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKL Sbjct: 181 QDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKL 240 Query: 242 MLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSL 301 MLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSL Sbjct: 241 MLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSL 300 Query: 302 YSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPAN 361 YSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKG VRPAN Sbjct: 301 YSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGDVRPAN 360 Query: 362 DFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEI 421 DFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEI Sbjct: 361 DFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEI 420 Query: 422 SGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDY 481 SGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDY Sbjct: 421 SGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDY 480 Query: 482 HKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDKT 541 HKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDKT Sbjct: 481 HKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDKT 540 Query: 542 SLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNKP 601 SLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNKP Sbjct: 541 SLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNKP 600 Query: 602 LFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGDF 661 LFFADKLYKSMKGAGTD+KTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGDF Sbjct: 601 LFFADKLYKSMKGAGTDDKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGDF 660 Query: 662 LKALLALCGGED 673 LKALLALCGGED Sbjct: 661 LKALLALCGGED 672 >1AVC-A nrPDB Length = 673 Score = 915 bits (2366), Expect = 0.0, Method: Composition-based stats. Identities = 632/673 (93%), Positives = 655/673 (97%) Query: 1 MAKPAQGAKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQ 60 MAK AQGAKYRGSI DFP F+P+QDAE LY AMKGFGSDKEAI+++ITSRSN+QRQE+CQ Sbjct: 1 MAKIAQGAKYRGSIRDFPDFNPSQDAETLYNAMKGFGSDKEAIINLITSRSNKQRQEICQ 60 Query: 61 SYKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILA 120 +YKSLYGKDLIADLKYELTGKFERLIVGLMRPPAY DAKEIKDAISGIGTDEKCLIEILA Sbjct: 61 NYKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYADAKEIKDAISGIGTDEKCLIEILA 120 Query: 121 SRTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQD 180 SRTNEQ+HQLVAAYKDAYERDLEADI GDTSGHF+KMLVVLLQGTREEDDVVSEDLVQQD Sbjct: 121 SRTNEQIHQLVAAYKDAYERDLEADITGDTSGHFRKMLVVLLQGTREEDDVVSEDLVQQD 180 Query: 181 VQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEK 240 VQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEK Sbjct: 181 VQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEK 240 Query: 241 LMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKS 300 LMLAVVKCIRST EYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKS Sbjct: 241 LMLAVVKCIRSTAEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKS 300 Query: 301 LYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPA 360 LYSMIKNDTSGEYKKTLLKL GGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPA Sbjct: 301 LYSMIKNDTSGEYKKTLLKLCGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPA 360 Query: 361 NDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSE 420 DFNPDADAKALRKAMKGLGTDEDTIIDIITHRSN QRQQIRQTFKSHFGRDLM DLKSE Sbjct: 361 GDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNAQRQQIRQTFKSHFGRDLMADLKSE 420 Query: 421 ISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKED 480 +SGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEI+AIN+AYKED Sbjct: 421 LSGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIQAINKAYKED 480 Query: 481 YHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDK 540 YHK+LEDALSSDTSGHF+RILISLATG+REEGGE+ ++AREDAQVAAEILEIADT SGDK Sbjct: 481 YHKTLEDALSSDTSGHFKRILISLATGNREEGGEDRERAREDAQVAAEILEIADTTSGDK 540 Query: 541 TSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNK 600 +SLETRFM ILCTRSYP LRRVFQEF+KMTNYDVEHTIKKEMSGDVRD FVAIVQSVKNK Sbjct: 541 SSLETRFMMILCTRSYPDLRRVFQEFVKMTNYDVEHTIKKEMSGDVRDVFVAIVQSVKNK 600 Query: 601 PLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGD 660 PLFFADKLYKSMKGAGT+EKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSG Sbjct: 601 PLFFADKLYKSMKGAGTEEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGH 660 Query: 661 FLKALLALCGGED 673 FLKALLA+CGGED Sbjct: 661 FLKALLAICGGED 673 >2ZHI-A nrPDB Length = 322 Score = 447 bits (1150), Expect = e-126, Method: Composition-based stats. Identities = 168/314 (53%), Positives = 227/314 (72%) Query: 12 GSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLI 71 G++ GF+ +DA+ L AMKG G+D++AI+ ++ R+ QRQE+ +YKS G+DL+ Sbjct: 9 GTVKAASGFNATEDAQVLRKAMKGLGTDEDAIIGVLACRNTAQRQEIRTAYKSTIGRDLL 68 Query: 72 ADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLV 131 DLK EL+ FE++I+G+M P D +E++ A+ G GTDE CLIEILASR E++ ++ Sbjct: 69 EDLKSELSSNFEQVILGMMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRNPEEIRRIN 128 Query: 132 AAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELK 191 Y+ Y R LE DI DTS FQ++LV L G R+E + + + LV+QD QDLYEAGE + Sbjct: 129 QTYQQQYGRSLEEDICSDTSFMFQRVLVSLTAGGRDEGNYLDDALVKQDAQDLYEAGEKR 188 Query: 192 WGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRS 251 WGTDE +F+ IL +R++ HL VFDEY + + K IE SI+ E SG FE +LA+VKC+R+ Sbjct: 189 WGTDEVKFLSILCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAIVKCMRN 248 Query: 252 TPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSG 311 P YFAERL+K+MKGLGT D+TLIR+MVSR+E+DMLDIR F+ Y KSLYS IK DTSG Sbjct: 249 KPAYFAERLYKSMKGLGTDDSTLIRVMVSRAEIDMLDIRANFKRLYGKSLYSFIKGDTSG 308 Query: 312 EYKKTLLKLSGGDD 325 +Y+K LL L GGDD Sbjct: 309 DYRKVLLILCGGDD 322 Score = 423 bits (1087), Expect = e-118, Method: Composition-based stats. Identities = 164/327 (50%), Positives = 227/327 (69%), Gaps = 7/327 (2%) Query: 348 VARVELKGTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKS 407 + GTV+ A+ FN DA+ LRKAMKGLGTDED II ++ R+ QRQ+IR +KS Sbjct: 2 IPMETKGGTVKAASGFNATEDAQVLRKAMKGLGTDEDAIIGVLACRNTAQRQEIRTAYKS 61 Query: 408 HFGRDLMTDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTN 467 GRDL+ DLKSE+S + ++ILG+M P YD ++L++AM+GAGTDE LIEILA+R Sbjct: 62 TIGRDLLEDLKSELSSNFEQVILGMMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRNP 121 Query: 468 AEIRAINEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLD-QAREDAQVA 526 EIR IN+ Y++ Y +SLE+ + SDTS F+R+L+SL G R+EG D ++DAQ Sbjct: 122 EEIRRINQTYQQQYGRSLEEDICSDTSFMFQRVLVSLTAGGRDEGNYLDDALVKQDAQ-- 179 Query: 527 AEILEIADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDV 586 ++ E + G E +F++ILC+R+ HL VF E+ +++ D+E +IK E SG Sbjct: 180 -DLYEAGEKRWGTD---EVKFLSILCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSF 235 Query: 587 RDAFVAIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYD 646 DA +AIV+ ++NKP +FA++LYKSMKG GTD+ TL R+MVSR+EID+L+IR F Y Sbjct: 236 EDALLAIVKCMRNKPAYFAERLYKSMKGLGTDDSTLIRVMVSRAEIDMLDIRANFKRLYG 295 Query: 647 KSLHQAIEGDTSGDFLKALLALCGGED 673 KSL+ I+GDTSGD+ K LL LCGG+D Sbjct: 296 KSLYSFIKGDTSGDYRKVLLILCGGDD 322 Score = 194 bits (494), Expect = 8e-50, Method: Composition-based stats. Identities = 92/336 (27%), Positives = 156/336 (46%), Gaps = 37/336 (11%) Query: 177 VQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSG 236 +D Q L +A + GTDE I +L R+ + + Y T G+ + ++ ELS Sbjct: 19 ATEDAQVLRKAMKG-LGTDEDAIIGVLACRNTAQRQEIRTAYKSTIGRDLLEDLKSELSS 77 Query: 237 DFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTK 296 +FE+++L + + T Y + L +AMKG GT + LI I+ SR+ ++ I + ++ + Sbjct: 78 NFEQVILGM---MTPTVLYDVQELRRAMKGAGTDEGCLIEILASRNPEEIRRINQTYQQQ 134 Query: 297 YEKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGT 356 Y +SL I +DTS +++ L+ L+ G D + Sbjct: 135 YGRSLEEDICSDTSFMFQRVLVSLTAGGRDEGNYLDDALVK------------------- 175 Query: 357 VRPANDFNPDADAKALRKA-MKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMT 415 DA+ L +A K GTDE + I+ R+ + +K +D+ Sbjct: 176 ----------QDAQDLYEAGEKRWGTDEVKFLSILCSRNRNHLLHVFDEYKRISQKDIEQ 225 Query: 416 DLKSEISGDLARLILGL---MMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRA 472 +KSE SG +L + M Y A++L K+M+G GTD+ LI ++ +R ++ Sbjct: 226 SIKSETSGSFEDALLAIVKCMRNKPAYFAERLYKSMKGLGTDDSTLIRVMVSRAEIDMLD 285 Query: 473 INEAYKEDYHKSLEDALSSDTSGHFRRILISLATGH 508 I +K Y KSL + DTSG +R++L+ L G Sbjct: 286 IRANFKRLYGKSLYSFIKGDTSGDYRKVLLILCGGD 321 >2ZOC-A nrPDB Length = 319 Score = 443 bits (1140), Expect = e-124, Method: Composition-based stats. Identities = 172/318 (54%), Positives = 229/318 (72%) Query: 8 AKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYG 67 A G++ GF+ +DA+ L AMKG G+D++AI+ ++ R+ QRQE+ +YKS G Sbjct: 2 ATKGGTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIG 61 Query: 68 KDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQM 127 +DLI DLK EL+G FE++IVG+M P D +E++ A+ G GTDE CLIEILASRT E++ Sbjct: 62 RDLIDDLKSELSGNFEQVIVGMMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRTPEEI 121 Query: 128 HQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEA 187 ++ Y+ Y R LE DI DTS FQ++LV L G R+E + + + LV+QD QDLYEA Sbjct: 122 RRISQTYQQQYGRSLEDDIRSDTSFMFQRVLVSLSAGGRDEGNYLDDALVRQDAQDLYEA 181 Query: 188 GELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVK 247 GE KWGTDE +F+ +L +R++ HL VFDEY + + K IE SI+ E SG FE +LA+VK Sbjct: 182 GEKKWGTDEVKFLTVLCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAIVK 241 Query: 248 CIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKN 307 C+R+ YFAE+L+K+MKGLGT DNTLIR+MVSR+E+DMLDIR F+ Y KSLYS IK Sbjct: 242 CMRNKSAYFAEKLYKSMKGLGTDDNTLIRVMVSRAEIDMLDIRAHFKRLYGKSLYSFIKG 301 Query: 308 DTSGEYKKTLLKLSGGDD 325 DTSG+Y+K LL L GGDD Sbjct: 302 DTSGDYRKVLLVLCGGDD 319 Score = 419 bits (1076), Expect = e-117, Method: Composition-based stats. Identities = 166/320 (51%), Positives = 229/320 (71%), Gaps = 7/320 (2%) Query: 355 GTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLM 414 GTV+ A+ FN DA+ LRKAMKGLGTDED II ++ +R+ QRQ+IR +KS GRDL+ Sbjct: 6 GTVKAASGFNAMEDAQTLRKAMKGLGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLI 65 Query: 415 TDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAIN 474 DLKSE+SG+ ++I+G+M P YD ++L++AM+GAGTDE LIEILA+RT EIR I+ Sbjct: 66 DDLKSELSGNFEQVIVGMMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRTPEEIRRIS 125 Query: 475 EAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLD-QAREDAQVAAEILEIA 533 + Y++ Y +SLED + SDTS F+R+L+SL+ G R+EG D R+DAQ ++ E Sbjct: 126 QTYQQQYGRSLEDDIRSDTSFMFQRVLVSLSAGGRDEGNYLDDALVRQDAQ---DLYEAG 182 Query: 534 DTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAI 593 + G E +F+T+LC+R+ HL VF E+ +++ D+E +IK E SG DA +AI Sbjct: 183 EKKWGTD---EVKFLTVLCSRNRNHLLHVFDEYKRISQKDIEQSIKSETSGSFEDALLAI 239 Query: 594 VQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAI 653 V+ ++NK +FA+KLYKSMKG GTD+ TL R+MVSR+EID+L+IR F Y KSL+ I Sbjct: 240 VKCMRNKSAYFAEKLYKSMKGLGTDDNTLIRVMVSRAEIDMLDIRAHFKRLYGKSLYSFI 299 Query: 654 EGDTSGDFLKALLALCGGED 673 +GDTSGD+ K LL LCGG+D Sbjct: 300 KGDTSGDYRKVLLVLCGGDD 319 Score = 195 bits (495), Expect = 7e-50, Method: Composition-based stats. Identities = 93/336 (27%), Positives = 157/336 (46%), Gaps = 37/336 (11%) Query: 177 VQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSG 236 +D Q L +A + GTDE I +L R+ + + Y T G+ + ++ ELSG Sbjct: 16 AMEDAQTLRKAMKG-LGTDEDAIISVLAYRNTAQRQEIRTAYKSTIGRDLIDDLKSELSG 74 Query: 237 DFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTK 296 +FE++ +V + T Y + L +AMKG GT + LI I+ SR+ ++ I + ++ + Sbjct: 75 NFEQV---IVGMMTPTVLYDVQELRRAMKGAGTDEGCLIEILASRTPEEIRRISQTYQQQ 131 Query: 297 YEKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGT 356 Y +SL I++DTS +++ L+ LS G D Sbjct: 132 YGRSLEDDIRSDTSFMFQRVLVSLSAGGRDEGNYLDDAL--------------------- 170 Query: 357 VRPANDFNPDADAKALRKA-MKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMT 415 DA+ L +A K GTDE + ++ R+ + +K +D+ Sbjct: 171 --------VRQDAQDLYEAGEKKWGTDEVKFLTVLCSRNRNHLLHVFDEYKRISQKDIEQ 222 Query: 416 DLKSEISGDLARLILGL---MMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRA 472 +KSE SG +L + M + Y A++L K+M+G GTD+ LI ++ +R ++ Sbjct: 223 SIKSETSGSFEDALLAIVKCMRNKSAYFAEKLYKSMKGLGTDDNTLIRVMVSRAEIDMLD 282 Query: 473 INEAYKEDYHKSLEDALSSDTSGHFRRILISLATGH 508 I +K Y KSL + DTSG +R++L+ L G Sbjct: 283 IRAHFKRLYGKSLYSFIKGDTSGDYRKVLLVLCGGD 318 >1I4A-A nrPDB Length = 318 Score = 436 bits (1121), Expect = e-122, Method: Composition-based stats. Identities = 168/314 (53%), Positives = 227/314 (72%) Query: 12 GSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLI 71 G + GF+ +DA+ L AMKG G+D++AI++++ RS QRQE+ +YK+ G+DL+ Sbjct: 5 GDVKAASGFNAAEDAQTLRKAMKGLGTDEDAIINVLAYRSTAQRQEIRTAYKTTIGRDLM 64 Query: 72 ADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLV 131 DLK EL+G FE++I+G+M P D +E++ A+ G GTDE CLIEILASRT E++ ++ Sbjct: 65 DDLKSELSGNFEQVILGMMTPTVLYDVQELRKAMKGAGTDEGCLIEILASRTPEEIRRIN 124 Query: 132 AAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELK 191 Y+ Y R LE DI DTS FQ++LV L G R+E + + + L++QD QDLYEAGE K Sbjct: 125 QTYQLQYGRSLEDDIRSDTSFMFQRVLVSLSAGGRDESNYLDDALMRQDAQDLYEAGEKK 184 Query: 192 WGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRS 251 WGTDE +F+ +L +R++ HL VFDEY + K IE SI+ E SG FE +LA+VKC+R+ Sbjct: 185 WGTDEVKFLTVLCSRNRNHLLHVFDEYKRIAQKDIEQSIKSETSGSFEDALLAIVKCMRN 244 Query: 252 TPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSG 311 YFAERL+K+MKGLGT D+TLIR+MVSR+E+DMLDIR F+ Y KSLYS IK DTSG Sbjct: 245 KSAYFAERLYKSMKGLGTDDDTLIRVMVSRAEIDMLDIRANFKRLYGKSLYSFIKGDTSG 304 Query: 312 EYKKTLLKLSGGDD 325 +Y+K LL L GGDD Sbjct: 305 DYRKVLLILCGGDD 318 Score = 413 bits (1062), Expect = e-115, Method: Composition-based stats. Identities = 167/320 (52%), Positives = 226/320 (70%), Gaps = 7/320 (2%) Query: 355 GTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLM 414 G V+ A+ FN DA+ LRKAMKGLGTDED II+++ +RS QRQ+IR +K+ GRDLM Sbjct: 5 GDVKAASGFNAAEDAQTLRKAMKGLGTDEDAIINVLAYRSTAQRQEIRTAYKTTIGRDLM 64 Query: 415 TDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAIN 474 DLKSE+SG+ ++ILG+M P YD ++L+KAM+GAGTDE LIEILA+RT EIR IN Sbjct: 65 DDLKSELSGNFEQVILGMMTPTVLYDVQELRKAMKGAGTDEGCLIEILASRTPEEIRRIN 124 Query: 475 EAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLD-QAREDAQVAAEILEIA 533 + Y+ Y +SLED + SDTS F+R+L+SL+ G R+E D R+DAQ ++ E Sbjct: 125 QTYQLQYGRSLEDDIRSDTSFMFQRVLVSLSAGGRDESNYLDDALMRQDAQ---DLYEAG 181 Query: 534 DTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAI 593 + G E +F+T+LC+R+ HL VF E+ ++ D+E +IK E SG DA +AI Sbjct: 182 EKKWGTD---EVKFLTVLCSRNRNHLLHVFDEYKRIAQKDIEQSIKSETSGSFEDALLAI 238 Query: 594 VQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAI 653 V+ ++NK +FA++LYKSMKG GTD+ TL R+MVSR+EID+L+IR F Y KSL+ I Sbjct: 239 VKCMRNKSAYFAERLYKSMKGLGTDDDTLIRVMVSRAEIDMLDIRANFKRLYGKSLYSFI 298 Query: 654 EGDTSGDFLKALLALCGGED 673 +GDTSGD+ K LL LCGG+D Sbjct: 299 KGDTSGDYRKVLLILCGGDD 318 Score = 192 bits (489), Expect = 3e-49, Method: Composition-based stats. Identities = 95/336 (28%), Positives = 159/336 (47%), Gaps = 37/336 (11%) Query: 177 VQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSG 236 +D Q L +A + GTDE I +L RS + + Y T G+ + ++ ELSG Sbjct: 15 AAEDAQTLRKAMKG-LGTDEDAIINVLAYRSTAQRQEIRTAYKTTIGRDLMDDLKSELSG 73 Query: 237 DFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTK 296 +FE+++L + + T Y + L KAMKG GT + LI I+ SR+ ++ I + ++ + Sbjct: 74 NFEQVILGM---MTPTVLYDVQELRKAMKGAGTDEGCLIEILASRTPEEIRRINQTYQLQ 130 Query: 297 YEKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGT 356 Y +SL I++DTS +++ L+ LS G D + Sbjct: 131 YGRSLEDDIRSDTSFMFQRVLVSLSAGGRDESNYLDDALM-------------------- 170 Query: 357 VRPANDFNPDADAKALRKA-MKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMT 415 DA+ L +A K GTDE + ++ R+ + +K +D+ Sbjct: 171 ---------RQDAQDLYEAGEKKWGTDEVKFLTVLCSRNRNHLLHVFDEYKRIAQKDIEQ 221 Query: 416 DLKSEISGDLARLILGL---MMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRA 472 +KSE SG +L + M + Y A++L K+M+G GTD+ LI ++ +R ++ Sbjct: 222 SIKSETSGSFEDALLAIVKCMRNKSAYFAERLYKSMKGLGTDDDTLIRVMVSRAEIDMLD 281 Query: 473 INEAYKEDYHKSLEDALSSDTSGHFRRILISLATGH 508 I +K Y KSL + DTSG +R++L+ L G Sbjct: 282 IRANFKRLYGKSLYSFIKGDTSGDYRKVLLILCGGD 317 >1YII-A nrPDB Length = 320 Score = 431 bits (1108), Expect = e-121, Method: Composition-based stats. Identities = 187/316 (59%), Positives = 230/316 (72%) Query: 11 RGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDL 70 RG++ F FD DAEAL AMKG G+D+E IL I+TSR+N QRQE+ ++K+L+G+DL Sbjct: 5 RGTVTAFSPFDARADAEALRKAMKGMGTDEETILKILTSRNNAQRQEIASAFKTLFGRDL 64 Query: 71 IADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQL 130 + DLK ELTGKFE L+V LMRP DA +K AI G GT+EK L EILASRT ++ + Sbjct: 65 VDDLKSELTGKFETLMVSLMRPARIFDAHALKHAIKGAGTNEKVLTEILASRTPAEVQNI 124 Query: 131 VAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGEL 190 Y YE +LE I G+TSGHFQ++LVVLLQ R+ D V E LV++D Q L+ AGEL Sbjct: 125 KQVYMQEYEANLEDKITGETSGHFQRLLVVLLQANRDPDGRVDEALVEKDAQVLFRAGEL 184 Query: 191 KWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIR 250 KWGTDE FI ILG RS HLR VFD+Y+ +G IE +I E SGD EKL+LAVVKCIR Sbjct: 185 KWGTDEETFITILGTRSVSHLRRVFDKYMTISGFQIEETIDRETSGDLEKLLLAVVKCIR 244 Query: 251 STPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTS 310 S P YFAE L+ +MKG GT D+TLIR+MVSRSE+D+LDIR FR + KSLY MI+ DTS Sbjct: 245 SVPAYFAETLYYSMKGAGTDDDTLIRVMVSRSEIDLLDIRHEFRKNFAKSLYQMIQKDTS 304 Query: 311 GEYKKTLLKLSGGDDD 326 G+Y+K LL L GGDD+ Sbjct: 305 GDYRKALLLLCGGDDE 320 Score = 407 bits (1046), Expect = e-114, Method: Composition-based stats. Identities = 159/321 (49%), Positives = 225/321 (70%), Gaps = 7/321 (2%) Query: 354 KGTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDL 413 +GTV + F+ ADA+ALRKAMKG+GTDE+TI+ I+T R+N QRQ+I FK+ FGRDL Sbjct: 5 RGTVTAFSPFDARADAEALRKAMKGMGTDEETILKILTSRNNAQRQEIASAFKTLFGRDL 64 Query: 414 MTDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAI 473 + DLKSE++G L++ LM P +DA LK A++GAGT+EK L EILA+RT AE++ I Sbjct: 65 VDDLKSELTGKFETLMVSLMRPARIFDAHALKHAIKGAGTNEKVLTEILASRTPAEVQNI 124 Query: 474 NEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGE-NLDQAREDAQVAAEILEI 532 + Y ++Y +LED ++ +TSGHF+R+L+ L +R+ G + +DAQV + Sbjct: 125 KQVYMQEYEANLEDKITGETSGHFQRLLVVLLQANRDPDGRVDEALVEKDAQV---LFRA 181 Query: 533 ADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVA 592 + G E F+TIL TRS HLRRVF +++ ++ + +E TI +E SGD+ +A Sbjct: 182 GELKWGTD---EETFITILGTRSVSHLRRVFDKYMTISGFQIEETIDRETSGDLEKLLLA 238 Query: 593 IVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQA 652 +V+ +++ P +FA+ LY SMKGAGTD+ TL R+MVSRSEIDLL+IR EF + + KSL+Q Sbjct: 239 VVKCIRSVPAYFAETLYYSMKGAGTDDDTLIRVMVSRSEIDLLDIRHEFRKNFAKSLYQM 298 Query: 653 IEGDTSGDFLKALLALCGGED 673 I+ DTSGD+ KALL LCGG+D Sbjct: 299 IQKDTSGDYRKALLLLCGGDD 319 Score = 187 bits (476), Expect = 1e-47, Method: Composition-based stats. Identities = 87/336 (25%), Positives = 164/336 (48%), Gaps = 37/336 (11%) Query: 177 VQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSG 236 + D + L +A + GTDE + IL +R+ + + + G+ + ++ EL+G Sbjct: 16 ARADAEALRKAMKG-MGTDEETILKILTSRNNAQRQEIASAFKTLFGRDLVDDLKSELTG 74 Query: 237 DFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTK 296 FE LM+++++ R + A L A+KG GT + L I+ SR+ ++ +I++++ + Sbjct: 75 KFETLMVSLMRPAR---IFDAHALKHAIKGAGTNEKVLTEILASRTPAEVQNIKQVYMQE 131 Query: 297 YEKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGT 356 YE +L I +TSG +++ L+ L + D G+ Sbjct: 132 YEANLEDKITGETSGHFQRLLVVLLQANRDPDGRVDEAL--------------------- 170 Query: 357 VRPANDFNPDADAKALRKAMK-GLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMT 415 + DA+ L +A + GTDE+T I I+ RS +++ + + G + Sbjct: 171 --------VEKDAQVLFRAGELKWGTDEETFITILGTRSVSHLRRVFDKYMTISGFQIEE 222 Query: 416 DLKSEISGDLARLILGLMM---PPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRA 472 + E SGDL +L+L ++ Y A+ L +M+GAGTD+ LI ++ +R+ ++ Sbjct: 223 TIDRETSGDLEKLLLAVVKCIRSVPAYFAETLYYSMKGAGTDDDTLIRVMVSRSEIDLLD 282 Query: 473 INEAYKEDYHKSLEDALSSDTSGHFRRILISLATGH 508 I +++++ KSL + DTSG +R+ L+ L G Sbjct: 283 IRHEFRKNFAKSLYQMIQKDTSGDYRKALLLLCGGD 318 >1SAV-A nrPDB Length = 320 Score = 429 bits (1104), Expect = e-120, Method: Composition-based stats. Identities = 182/315 (57%), Positives = 234/315 (74%) Query: 11 RGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDL 70 RG++ DFPGFD DAE L AMKG G+D+E+IL ++TSRSN QRQE+ ++K+L+G+DL Sbjct: 6 RGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTLFGRDL 65 Query: 71 IADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQL 130 + DLK ELTGKFE+LIV LM+P DA E+K A+ G GT+EK L EI+ASRT E++ + Sbjct: 66 LDDLKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTNEKVLTEIIASRTPEELRAI 125 Query: 131 VAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGEL 190 Y++ Y LE D++GDTSG++Q+MLVVLLQ R+ D + E V+QD Q L++AGEL Sbjct: 126 KQVYEEEYGSSLEDDVVGDTSGYYQRMLVVLLQANRDPDAGIDEAQVEQDAQALFQAGEL 185 Query: 191 KWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIR 250 KWGTDE +FI I G RS HLR VFD+Y+ +G IE +I E SG+ E+L+LAVVK IR Sbjct: 186 KWGTDEEKFITIFGTRSVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIR 245 Query: 251 STPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTS 310 S P Y AE L+ AMKG GT D+TLIR+MVSRSE+D+ +IR+ FR + SLYSMIK DTS Sbjct: 246 SIPAYLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTS 305 Query: 311 GEYKKTLLKLSGGDD 325 G+YKK LL L G DD Sbjct: 306 GDYKKALLLLCGEDD 320 Score = 401 bits (1031), Expect = e-112, Method: Composition-based stats. Identities = 156/322 (48%), Positives = 225/322 (69%), Gaps = 7/322 (2%) Query: 353 LKGTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRD 412 L+GTV F+ ADA+ LRKAMKGLGTDE++I+ ++T RSN QRQ+I FK+ FGRD Sbjct: 5 LRGTVTDFPGFDERADAETLRKAMKGLGTDEESILTLLTSRSNAQRQEISAAFKTLFGRD 64 Query: 413 LMTDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRA 472 L+ DLKSE++G +LI+ LM P YDA +LK A++GAGT+EK L EI+A+RT E+RA Sbjct: 65 LLDDLKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTNEKVLTEIIASRTPEELRA 124 Query: 473 INEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEG-GENLDQAREDAQVAAEILE 531 I + Y+E+Y SLED + DTSG+++R+L+ L +R+ G + Q +DAQ + + Sbjct: 125 IKQVYEEEYGSSLEDDVVGDTSGYYQRMLVVLLQANRDPDAGIDEAQVEQDAQA---LFQ 181 Query: 532 IADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFV 591 + G E +F+TI TRS HLR+VF +++ ++ + +E TI +E SG++ + Sbjct: 182 AGELKWGTD---EEKFITIFGTRSVSHLRKVFDKYMTISGFQIEETIDRETSGNLEQLLL 238 Query: 592 AIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQ 651 A+V+S+++ P + A+ LY +MKGAGTD+ TL R+MVSRSEIDL NIR+EF + + SL+ Sbjct: 239 AVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNIRKEFRKNFATSLYS 298 Query: 652 AIEGDTSGDFLKALLALCGGED 673 I+GDTSGD+ KALL LCG +D Sbjct: 299 MIKGDTSGDYKKALLLLCGEDD 320 Score = 182 bits (463), Expect = 3e-46, Method: Composition-based stats. Identities = 87/331 (26%), Positives = 159/331 (48%), Gaps = 37/331 (11%) Query: 178 QQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGD 237 + D + L +A + GTDE + +L +RS + + + G+ + ++ EL+G Sbjct: 18 RADAETLRKAMKG-LGTDEESILTLLTSRSNAQRQEISAAFKTLFGRDLLDDLKSELTGK 76 Query: 238 FEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKY 297 FEKL++A++K R Y A L A+KG GT + L I+ SR+ ++ I++++ +Y Sbjct: 77 FEKLIVALMKPSR---LYDAYELKHALKGAGTNEKVLTEIIASRTPEELRAIKQVYEEEY 133 Query: 298 EKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTV 357 SL + DTSG Y++ L+ L + D Sbjct: 134 GSSLEDDVVGDTSGYYQRMLVVLLQANRDPDAGIDEA----------------------- 170 Query: 358 RPANDFNPDADAKALRKAMK-GLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTD 416 + DA+AL +A + GTDE+ I I RS +++ + + G + Sbjct: 171 ------QVEQDAQALFQAGELKWGTDEEKFITIFGTRSVSHLRKVFDKYMTISGFQIEET 224 Query: 417 LKSEISGDLARLILGLMM---PPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAI 473 + E SG+L +L+L ++ Y A+ L AM+GAGTD+ LI ++ +R+ ++ I Sbjct: 225 IDRETSGNLEQLLLAVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVMVSRSEIDLFNI 284 Query: 474 NEAYKEDYHKSLEDALSSDTSGHFRRILISL 504 + +++++ SL + DTSG +++ L+ L Sbjct: 285 RKEFRKNFATSLYSMIKGDTSGDYKKALLLL 315 >2IE7-A nrPDB Length = 318 Score = 427 bits (1097), Expect = e-119, Method: Composition-based stats. Identities = 178/316 (56%), Positives = 237/316 (75%) Query: 11 RGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDL 70 RG++ DF GFD DAE L AMKG G+D+++IL+++T+RSN QRQ++ + +K+L+G+DL Sbjct: 3 RGTVTDFSGFDGRADAEVLRKAMKGLGTDEDSILNLLTARSNAQRQQIAEEFKTLFGRDL 62 Query: 71 IADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQL 130 + D+K ELTGKFE+LIV LM+P DA E+K A+ G GTDEK L EI+ASRT E++ + Sbjct: 63 VNDMKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTDEKVLTEIIASRTPEELRAI 122 Query: 131 VAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGEL 190 AY++ Y +LE D++GDTSG++Q+MLVVLLQ R+ D + + V+ D Q L++AGEL Sbjct: 123 KQAYEEEYGSNLEDDVVGDTSGYYQRMLVVLLQANRDPDTAIDDAQVELDAQALFQAGEL 182 Query: 191 KWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIR 250 KWGTDE +FI ILG RS HLR VFD+Y+ +G IE +I E SG+ E L+LAVVK IR Sbjct: 183 KWGTDEEKFITILGTRSVSHLRRVFDKYMTISGFQIEETIDRETSGNLENLLLAVVKSIR 242 Query: 251 STPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTS 310 S P Y AE L+ AMKG GT D+TLIR++VSRSE+D+ +IR+ FR + SLYSMIK DTS Sbjct: 243 SIPAYLAETLYYAMKGAGTDDHTLIRVIVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTS 302 Query: 311 GEYKKTLLKLSGGDDD 326 G+YKK LL L GG+DD Sbjct: 303 GDYKKALLLLCGGEDD 318 Score = 400 bits (1028), Expect = e-112, Method: Composition-based stats. Identities = 161/321 (50%), Positives = 231/321 (71%), Gaps = 5/321 (1%) Query: 353 LKGTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRD 412 L+GTV + F+ ADA+ LRKAMKGLGTDED+I++++T RSN QRQQI + FK+ FGRD Sbjct: 2 LRGTVTDFSGFDGRADAEVLRKAMKGLGTDEDSILNLLTARSNAQRQQIAEEFKTLFGRD 61 Query: 413 LMTDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRA 472 L+ D+KSE++G +LI+ LM P YDA +LK A++GAGTDEK L EI+A+RT E+RA Sbjct: 62 LVNDMKSELTGKFEKLIVALMKPSRLYDAYELKHALKGAGTDEKVLTEIIASRTPEELRA 121 Query: 473 INEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEI 532 I +AY+E+Y +LED + DTSG+++R+L+ L +R+ D A +DAQV + + Sbjct: 122 IKQAYEEEYGSNLEDDVVGDTSGYYQRMLVVLLQANRDP-----DTAIDDAQVELDAQAL 176 Query: 533 ADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVA 592 + E +F+TIL TRS HLRRVF +++ ++ + +E TI +E SG++ + +A Sbjct: 177 FQAGELKWGTDEEKFITILGTRSVSHLRRVFDKYMTISGFQIEETIDRETSGNLENLLLA 236 Query: 593 IVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQA 652 +V+S+++ P + A+ LY +MKGAGTD+ TL R++VSRSEIDL NIR+EF + + SL+ Sbjct: 237 VVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVIVSRSEIDLFNIRKEFRKNFATSLYSM 296 Query: 653 IEGDTSGDFLKALLALCGGED 673 I+GDTSGD+ KALL LCGGED Sbjct: 297 IKGDTSGDYKKALLLLCGGED 317 Score = 183 bits (465), Expect = 2e-46, Method: Composition-based stats. Identities = 89/337 (26%), Positives = 163/337 (48%), Gaps = 37/337 (10%) Query: 178 QQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGD 237 + D + L +A + GTDE + +L RS + + +E+ G+ + ++ EL+G Sbjct: 15 RADAEVLRKAMKG-LGTDEDSILNLLTARSNAQRQQIAEEFKTLFGRDLVNDMKSELTGK 73 Query: 238 FEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKY 297 FEKL++A++K R Y A L A+KG GT + L I+ SR+ ++ I++ + +Y Sbjct: 74 FEKLIVALMKPSR---LYDAYELKHALKGAGTDEKVLTEIIASRTPEELRAIKQAYEEEY 130 Query: 298 EKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTV 357 +L + DTSG Y++ L+ L + D Sbjct: 131 GSNLEDDVVGDTSGYYQRMLVVLLQANRDPD----------------------------- 161 Query: 358 RPANDFNPDADAKALRKAMK-GLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTD 416 +D + DA+AL +A + GTDE+ I I+ RS +++ + + G + Sbjct: 162 TAIDDAQVELDAQALFQAGELKWGTDEEKFITILGTRSVSHLRRVFDKYMTISGFQIEET 221 Query: 417 LKSEISGDLARLILGLMM---PPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAI 473 + E SG+L L+L ++ Y A+ L AM+GAGTD+ LI ++ +R+ ++ I Sbjct: 222 IDRETSGNLENLLLAVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVIVSRSEIDLFNI 281 Query: 474 NEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHRE 510 + +++++ SL + DTSG +++ L+ L G + Sbjct: 282 RKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGGEDD 318 >1AII-A nrPDB Length = 323 Score = 420 bits (1080), Expect = e-118, Method: Composition-based stats. Identities = 164/316 (51%), Positives = 224/316 (70%) Query: 10 YRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKD 69 +RG++ D+P F P+ DAEA+ A++G G+D++ ++ I+T RSN QRQ + + Y++ YGK+ Sbjct: 8 HRGTVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISILTERSNAQRQLIVKEYQAAYGKE 67 Query: 70 LIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQ 129 L DLK +L+G FE L+V L+ PPA DAK++K ++ G GT+E LIEIL +RT+ QM Sbjct: 68 LKDDLKGDLSGHFEHLMVALVTPPAVFDAKQLKKSMKGAGTNEDALIEILTTRTSRQMKD 127 Query: 130 LVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGE 189 + AY Y++ L DI +TSG F+K L+ L G R+E V E L +QD Q LY+AGE Sbjct: 128 ISQAYYTVYKKSLGDDISSETSGDFRKALLTLADGRRDESLKVDEHLAKQDAQILYKAGE 187 Query: 190 LKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCI 249 +WGTDE +F IL RS L+L FDEY + K I SI+GELSG FE L+LA+V C+ Sbjct: 188 NRWGTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIVDSIKGELSGHFEDLLLAIVNCV 247 Query: 250 RSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDT 309 R+TP + AERL +A+KG+GT + TL RIMVSRSE+D+LDIR F+ Y SLYS IK+DT Sbjct: 248 RNTPAFLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRTEFKKHYGYSLYSAIKSDT 307 Query: 310 SGEYKKTLLKLSGGDD 325 SG+Y+ TLLK+ GGDD Sbjct: 308 SGDYEITLLKICGGDD 323 Score = 397 bits (1021), Expect = e-111, Method: Composition-based stats. Identities = 156/328 (47%), Positives = 225/328 (68%), Gaps = 7/328 (2%) Query: 347 AVARVELKGTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFK 406 A V +GTVR DF+P DA+A++KA++G+GTDE +I I+T RSN QRQ I + ++ Sbjct: 2 ASIWVGHRGTVRDYPDFSPSVDAEAIQKAIRGIGTDEKMLISILTERSNAQRQLIVKEYQ 61 Query: 407 SHFGRDLMTDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRT 466 + +G++L DLK ++SG L++ L+ PPA +DAKQLKK+M+GAGT+E ALIEIL TRT Sbjct: 62 AAYGKELKDDLKGDLSGHFEHLMVALVTPPAVFDAKQLKKSMKGAGTNEDALIEILTTRT 121 Query: 467 NAEIRAINEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEG-GENLDQAREDAQV 525 + +++ I++AY Y KSL D +SS+TSG FR+ L++LA G R+E + A++DAQ+ Sbjct: 122 SRQMKDISQAYYTVYKKSLGDDISSETSGDFRKALLTLADGRRDESLKVDEHLAKQDAQI 181 Query: 526 AAEILEIADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGD 585 + + + G E +F ILC RS+P L+ F E+ ++ D+ +IK E+SG Sbjct: 182 ---LYKAGENRWGTD---EDKFTEILCLRSFPQLKLTFDEYRNISQKDIVDSIKGELSGH 235 Query: 586 VRDAFVAIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKY 645 D +AIV V+N P F A++L++++KG GTDE TL RIMVSRSEIDLL+IR EF + Y Sbjct: 236 FEDLLLAIVNCVRNTPAFLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRTEFKKHY 295 Query: 646 DKSLHQAIEGDTSGDFLKALLALCGGED 673 SL+ AI+ DTSGD+ LL +CGG+D Sbjct: 296 GYSLYSAIKSDTSGDYEITLLKICGGDD 323 Score = 208 bits (530), Expect = 5e-54, Method: Composition-based stats. Identities = 102/333 (30%), Positives = 168/333 (50%), Gaps = 37/333 (11%) Query: 180 DVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFE 239 D + + +A GTDE I IL RS +L+ EY GK ++ ++G+LSG FE Sbjct: 23 DAEAIQKAIRG-IGTDEKMLISILTERSNAQRQLIVKEYQAAYGKELKDDLKGDLSGHFE 81 Query: 240 KLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEK 299 LM+A+V + A++L K+MKG GT ++ LI I+ +R+ M DI + + T Y+K Sbjct: 82 HLMVALV---TPPAVFDAKQLKKSMKGAGTNEDALIEILTTRTSRQMKDISQAYYTVYKK 138 Query: 300 SLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRP 359 SL I ++TSG+++K LL L+ G D + + A+ Sbjct: 139 SLGDDISSETSGDFRKALLTLADGRRDESLKVDEHLAK---------------------- 176 Query: 360 ANDFNPDADAKALRKAMKG-LGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLK 418 DA+ L KA + GTDED +I+ RS Q + +++ +D++ +K Sbjct: 177 -------QDAQILYKAGENRWGTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIVDSIK 229 Query: 419 SEISGDLARLILGL---MMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINE 475 E+SG L+L + + + A++L +A++G GTDE L I+ +R+ ++ I Sbjct: 230 GELSGHFEDLLLAIVNCVRNTPAFLAERLHRALKGIGTDEFTLNRIMVSRSEIDLLDIRT 289 Query: 476 AYKEDYHKSLEDALSSDTSGHFRRILISLATGH 508 +K+ Y SL A+ SDTSG + L+ + G Sbjct: 290 EFKKHYGYSLYSAIKSDTSGDYEITLLKICGGD 322 >5N7D-A nrPDB Length = 427 Score = 410 bits (1055), Expect = e-115, Method: Composition-based stats. Identities = 153/320 (47%), Positives = 216/320 (67%), Gaps = 1/320 (0%) Query: 7 GAKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLY 66 G+ GS+ + FD +DA + TA+K G D+ I++I+T+RSN QRQ++ +Y+ Sbjct: 108 GSSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRT 167 Query: 67 GKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQ 126 K+L + LK L+G E +I+GL++ PA DA E+K ++ G+GTDE LIEI+ SRTN++ Sbjct: 168 KKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQE 227 Query: 127 MHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREED-DVVSEDLVQQDVQDLY 185 + ++ YK+ Y+ DLE DII DTSG F+K++V L +G R ED V+ +L+ QD +DLY Sbjct: 228 LQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLY 287 Query: 186 EAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAV 245 +AG + GTD ++I I+ RS HL+ VFD Y + + SIR E+ GD E L + Sbjct: 288 DAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNL 347 Query: 246 VKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMI 305 V+CI++ P YFA+RL+ +MKG GTRD LIRIMVSRSE+DML IR F+ KY KSLY I Sbjct: 348 VQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYI 407 Query: 306 KNDTSGEYKKTLLKLSGGDD 325 + DT G+Y+K LL L GGDD Sbjct: 408 QQDTKGDYQKALLYLCGGDD 427 Score = 389 bits (1000), Expect = e-108, Method: Composition-based stats. Identities = 148/319 (46%), Positives = 213/319 (66%), Gaps = 4/319 (1%) Query: 355 GTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLM 414 G+V+ +F+ + DA + A+K G DE TI++I+T+RSN QRQ I ++ ++L Sbjct: 113 GSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELA 172 Query: 415 TDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAIN 474 + LKS +SG L +ILGL+ PA YDA +LK +M+G GTDE +LIEI+ +RTN E++ IN Sbjct: 173 SALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEIN 232 Query: 475 EAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIAD 534 YKE Y LE + SDTSG FR+++++LA G R E G +D D Q A ++ + Sbjct: 233 RVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELID-QDARDLYDAGV 291 Query: 535 TPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIV 594 G ++++I+ RS PHL++VF + + YD+ +I+KE+ GD+ +AF+ +V Sbjct: 292 KRKGTD---VPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLV 348 Query: 595 QSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIE 654 Q ++NKPL+FAD+LY SMKG GT +K L RIMVSRSE+D+L IR EF KY KSL+ I+ Sbjct: 349 QCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQ 408 Query: 655 GDTSGDFLKALLALCGGED 673 DT GD+ KALL LCGG+D Sbjct: 409 QDTKGDYQKALLYLCGGDD 427 Score = 181 bits (459), Expect = 8e-46, Method: Composition-based stats. Identities = 94/336 (27%), Positives = 163/336 (48%), Gaps = 36/336 (10%) Query: 177 VQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSG 236 ++D ++ A + K G DE + IL NRS + + + Y + T K + ++++ LSG Sbjct: 123 AERDALNIETAIKTK-GVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSALSG 181 Query: 237 DFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTK 296 E ++L ++K + +Y A L +MKGLGT +++LI I+ SR+ ++ +I +++ Sbjct: 182 HLETVILGLLK---TPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEM 238 Query: 297 YEKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGT 356 Y+ L I +DTSG+++K ++ L+ G G Sbjct: 239 YKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELI------------------- 279 Query: 357 VRPANDFNPDADAKALRKA-MKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMT 415 D DA+ L A +K GTD I I+T RS Q++ +KS+ D++ Sbjct: 280 ---------DQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLE 330 Query: 416 DLKSEISGDLARLILGL---MMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRA 472 ++ E+ GDL L L + Y A +L +M+G GT +K LI I+ +R+ ++ Sbjct: 331 SIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLK 390 Query: 473 INEAYKEDYHKSLEDALSSDTSGHFRRILISLATGH 508 I +K Y KSL + DT G +++ L+ L G Sbjct: 391 IRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGD 426 >1HM6-A nrPDB Length = 346 Score = 404 bits (1039), Expect = e-113, Method: Composition-based stats. Identities = 143/313 (45%), Positives = 198/313 (63%) Query: 12 GSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLI 71 ++ +P F+P+ D EAL+ A+ G D+ I++I+T R+N QRQ++ +Y GK L Sbjct: 34 SAVSPYPTFNPSSDVEALHKAITVKGVDEATIIEILTKRTNAQRQQIKAAYLQEKGKPLD 93 Query: 72 ADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLV 131 LK LTG E + + L++ PA DA E++ A+ G+GTDE L EILASRTN ++ ++ Sbjct: 94 EALKKALTGHLEEVALALLKTPAQFDADELRAAMKGLGTDEDTLNEILASRTNREIREIN 153 Query: 132 AAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELK 191 YK+ +RDL DI DTSG +QK L+ L +G R ED +++DL D + LYEAGE + Sbjct: 154 RVYKEELKRDLAKDITSDTSGDYQKALLSLAKGDRSEDLAINDDLADTDARALYEAGERR 213 Query: 192 WGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRS 251 GTD FI IL RS HLR VF +Y K + + + EL GD E + VVKC S Sbjct: 214 KGTDLNVFITILTTRSYPHLRRVFQKYSKYSKHDMNKVLDLELKGDIENCLTVVVKCATS 273 Query: 252 TPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSG 311 P +FAE+L +AMKG+GTR TLIRIMVSRSE+DM DI+ ++ Y SL I ++T G Sbjct: 274 KPMFFAEKLHQAMKGIGTRHKTLIRIMVSRSEIDMNDIKACYQKLYGISLCQAILDETKG 333 Query: 312 EYKKTLLKLSGGD 324 +Y+K L+ L GGD Sbjct: 334 DYEKILVALCGGD 346 Score = 385 bits (988), Expect = e-107, Method: Composition-based stats. Identities = 145/317 (45%), Positives = 203/317 (64%), Gaps = 7/317 (2%) Query: 357 VRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTD 416 V P FNP +D +AL KA+ G DE TII+I+T R+N QRQQI+ + G+ L Sbjct: 36 VSPYPTFNPSSDVEALHKAITVKGVDEATIIEILTKRTNAQRQQIKAAYLQEKGKPLDEA 95 Query: 417 LKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEA 476 LK ++G L + L L+ PA +DA +L+ AM+G GTDE L EILA+RTN EIR IN Sbjct: 96 LKKALTGHLEEVALALLKTPAQFDADELRAAMKGLGTDEDTLNEILASRTNREIREINRV 155 Query: 477 YKEDYHKSLEDALSSDTSGHFRRILISLATGHREEG-GENLDQAREDAQVAAEILEIADT 535 YKE+ + L ++SDTSG +++ L+SLA G R E N D A DA+ + E + Sbjct: 156 YKEELKRDLAKDITSDTSGDYQKALLSLAKGDRSEDLAINDDLADTDARA---LYEAGER 212 Query: 536 PSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQ 595 G ++ F+TIL TRSYPHLRRVFQ++ K + +D+ + E+ GD+ + +V+ Sbjct: 213 RKGTDLNV---FITILTTRSYPHLRRVFQKYSKYSKHDMNKVLDLELKGDIENCLTVVVK 269 Query: 596 SVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEG 655 +KP+FFA+KL+++MKG GT KTL RIMVSRSEID+ +I+ + + Y SL QAI Sbjct: 270 CATSKPMFFAEKLHQAMKGIGTRHKTLIRIMVSRSEIDMNDIKACYQKLYGISLCQAILD 329 Query: 656 DTSGDFLKALLALCGGE 672 +T GD+ K L+ALCGG+ Sbjct: 330 ETKGDYEKILVALCGGD 346 Score = 192 bits (487), Expect = 5e-49, Method: Composition-based stats. Identities = 96/336 (28%), Positives = 170/336 (50%), Gaps = 37/336 (11%) Query: 177 VQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSG 236 DV+ L++A +K G DEA I IL R+ + + YL+ GKP++ +++ L+G Sbjct: 44 PSSDVEALHKAITVK-GVDEATIIEILTKRTNAQRQQIKAAYLQEKGKPLDEALKKALTG 102 Query: 237 DFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTK 296 E++ LA++K + ++ A+ L AMKGLGT ++TL I+ SR+ ++ +I +++ + Sbjct: 103 HLEEVALALLK---TPAQFDADELRAAMKGLGTDEDTLNEILASRTNREIREINRVYKEE 159 Query: 297 YEKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGT 356 ++ L I +DTSG+Y+K LL L+ GD + Sbjct: 160 LKRDLAKDITSDTSGDYQKALLSLAKGDRSEDLAINDDL--------------------- 198 Query: 357 VRPANDFNPDADAKALRKA-MKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMT 415 D DA+AL +A + GTD + I I+T RS +++ Q + + D+ Sbjct: 199 --------ADTDARALYEAGERRKGTDLNVFITILTTRSYPHLRRVFQKYSKYSKHDMNK 250 Query: 416 DLKSEISGDLA---RLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRA 472 L E+ GD+ +++ + A++L +AM+G GT K LI I+ +R+ ++ Sbjct: 251 VLDLELKGDIENCLTVVVKCATSKPMFFAEKLHQAMKGIGTRHKTLIRIMVSRSEIDMND 310 Query: 473 INEAYKEDYHKSLEDALSSDTSGHFRRILISLATGH 508 I Y++ Y SL A+ +T G + +IL++L G Sbjct: 311 IKACYQKLYGISLCQAILDETKGDYEKILVALCGGD 346 >1AIN-A nrPDB Length = 314 Score = 404 bits (1039), Expect = e-113, Method: Composition-based stats. Identities = 141/313 (45%), Positives = 197/313 (62%) Query: 12 GSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLI 71 ++ +P F+P+ D AL+ A+ G D+ I+DI+T R+N QRQ++ +Y GK L Sbjct: 2 SAVSPYPTFNPSSDVAALHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLD 61 Query: 72 ADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLV 131 LK LTG E +++ L++ PA DA E++ A+ G+GTDE LIEILASRTN+++ + Sbjct: 62 ETLKKALTGHLEEVVLALLKTPAQFDADELRAAMKGLGTDEDTLIEILASRTNKEIRDIN 121 Query: 132 AAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELK 191 Y++ +RDL DI DTSG F+ L+ L +G R ED V+EDL D + LYEAGE + Sbjct: 122 RVYREELKRDLAKDITSDTSGDFRNALLSLAKGDRSEDFGVNEDLADSDARALYEAGERR 181 Query: 192 WGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRS 251 GTD F IL RS LR VF +Y K + + + EL GD EK + A+VKC S Sbjct: 182 KGTDVNVFNTILTTRSYPQLRRVFQKYTKYSKHDMNKVLDLELKGDIEKCLTAIVKCATS 241 Query: 252 TPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSG 311 P +FAE+L +AMKG+GTR LIRIMVSRSE+DM DI+ ++ Y SL I ++T G Sbjct: 242 KPAFFAEKLHQAMKGVGTRHKALIRIMVSRSEIDMNDIKAFYQKMYGISLCQAILDETKG 301 Query: 312 EYKKTLLKLSGGD 324 +Y+K L+ L GG+ Sbjct: 302 DYEKILVALCGGN 314 Score = 385 bits (990), Expect = e-107, Method: Composition-based stats. Identities = 149/317 (47%), Positives = 199/317 (62%), Gaps = 7/317 (2%) Query: 357 VRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTD 416 V P FNP +D AL KA+ G DE TIIDI+T R+N QRQQI+ + G+ L Sbjct: 4 VSPYPTFNPSSDVAALHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDET 63 Query: 417 LKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEA 476 LK ++G L ++L L+ PA +DA +L+ AM+G GTDE LIEILA+RTN EIR IN Sbjct: 64 LKKALTGHLEEVVLALLKTPAQFDADELRAAMKGLGTDEDTLIEILASRTNKEIRDINRV 123 Query: 477 YKEDYHKSLEDALSSDTSGHFRRILISLATGHREEG-GENLDQAREDAQVAAEILEIADT 535 Y+E+ + L ++SDTSG FR L+SLA G R E G N D A DA+ + E + Sbjct: 124 YREELKRDLAKDITSDTSGDFRNALLSLAKGDRSEDFGVNEDLADSDARA---LYEAGER 180 Query: 536 PSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQ 595 G ++ F TIL TRSYP LRRVFQ++ K + +D+ + E+ GD+ AIV+ Sbjct: 181 RKGTDVNV---FNTILTTRSYPQLRRVFQKYTKYSKHDMNKVLDLELKGDIEKCLTAIVK 237 Query: 596 SVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEG 655 +KP FFA+KL+++MKG GT K L RIMVSRSEID+ +I+ + + Y SL QAI Sbjct: 238 CATSKPAFFAEKLHQAMKGVGTRHKALIRIMVSRSEIDMNDIKAFYQKMYGISLCQAILD 297 Query: 656 DTSGDFLKALLALCGGE 672 +T GD+ K L+ALCGG Sbjct: 298 ETKGDYEKILVALCGGN 314 Score = 195 bits (496), Expect = 5e-50, Method: Composition-based stats. Identities = 99/336 (29%), Positives = 175/336 (52%), Gaps = 37/336 (11%) Query: 177 VQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSG 236 DV L++A +K G DEA I IL R+ + + YL+ TGKP++ +++ L+G Sbjct: 12 PSSDVAALHKAIMVK-GVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTG 70 Query: 237 DFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTK 296 E+++LA++K + ++ A+ L AMKGLGT ++TLI I+ SR+ ++ DI ++R + Sbjct: 71 HLEEVVLALLK---TPAQFDADELRAAMKGLGTDEDTLIEILASRTNKEIRDINRVYREE 127 Query: 297 YEKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGT 356 ++ L I +DTSG+++ LL L+ GD + Sbjct: 128 LKRDLAKDITSDTSGDFRNALLSLAKGDRSEDFGVNEDL--------------------- 166 Query: 357 VRPANDFNPDADAKALRKA-MKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMT 415 D+DA+AL +A + GTD + I+T RS Q +++ Q + + D+ Sbjct: 167 --------ADSDARALYEAGERRKGTDVNVFNTILTTRSYPQLRRVFQKYTKYSKHDMNK 218 Query: 416 DLKSEISGDLARLILGLMM---PPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRA 472 L E+ GD+ + + ++ + A++L +AM+G GT KALI I+ +R+ ++ Sbjct: 219 VLDLELKGDIEKCLTAIVKCATSKPAFFAEKLHQAMKGVGTRHKALIRIMVSRSEIDMND 278 Query: 473 INEAYKEDYHKSLEDALSSDTSGHFRRILISLATGH 508 I Y++ Y SL A+ +T G + +IL++L G+ Sbjct: 279 IKAFYQKMYGISLCQAILDETKGDYEKILVALCGGN 314 >1W3W-A nrPDB Length = 327 Score = 404 bits (1038), Expect = e-113, Method: Composition-based stats. Identities = 165/313 (52%), Positives = 215/313 (68%), Gaps = 1/313 (0%) Query: 13 SIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIA 72 ++ F+P+ DAE LY AMKG G++++AI+D++T RSN QRQ++ +S+K+ +GKDL Sbjct: 14 TVKSSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIAKSFKAQFGKDLTE 73 Query: 73 DLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVA 132 LK EL+GKFERLIV LM PP +AKE+ DA+ G+GT E +IEILASRT Q+ +++ Sbjct: 74 TLKSELSGKFERLIVALMYPPYRYEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMK 133 Query: 133 AYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREE-DDVVSEDLVQQDVQDLYEAGELK 191 AY++ Y LE DI DTSG+ +++LV LLQG+R++ V L QD QDLY AGE Sbjct: 134 AYEEDYGSSLEEDIQADTSGYLERILVCLLQGSRDDVSSFVDPALALQDAQDLYAAGEKI 193 Query: 192 WGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRS 251 GTDE +FI IL RS HL VF+EY K K IE SI+ E G E+ ML VVKC ++ Sbjct: 194 RGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSETHGSLEEAMLTVVKCTQN 253 Query: 252 TPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSG 311 YFAERL+ AMKG GTRD TLIR +VSRSE+D+ I+ F+ Y K+L SMI DTSG Sbjct: 254 LHSYFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGKTLSSMIMEDTSG 313 Query: 312 EYKKTLLKLSGGD 324 +YK LL L G D Sbjct: 314 DYKNALLSLVGSD 326 Score = 389 bits (1000), Expect = e-108, Method: Composition-based stats. Identities = 155/325 (47%), Positives = 216/325 (66%), Gaps = 5/325 (1%) Query: 349 ARVELKG-TVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKS 407 A +E +G TV+ ++ FNPD DA+ L KAMKG+GT+E IID++T RSN QRQQI ++FK+ Sbjct: 6 AWIEQEGVTVKSSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIAKSFKA 65 Query: 408 HFGRDLMTDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTN 467 FG+DL LKSE+SG RLI+ LM PP Y+AK+L AM+G GT E +IEILA+RT Sbjct: 66 QFGKDLTETLKSELSGKFERLIVALMYPPYRYEAKELHDAMKGLGTKEGVIIEILASRTK 125 Query: 468 AEIRAINEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAA 527 ++R I +AY+EDY SLE+ + +DTSG+ RIL+ L G R++ +D A Q A Sbjct: 126 NQLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCLLQGSRDDVSSFVDPALA-LQDAQ 184 Query: 528 EILEIADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVR 587 ++ + G E +F+TILCTRS HL RVF+E+ K+ N +E +IK E G + Sbjct: 185 DLYAAGEKIRGTD---EMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSETHGSLE 241 Query: 588 DAFVAIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDK 647 +A + +V+ +N +FA++LY +MKGAGT + TL R +VSRSEIDL I+ F + Y K Sbjct: 242 EAMLTVVKCTQNLHSYFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYGK 301 Query: 648 SLHQAIEGDTSGDFLKALLALCGGE 672 +L I DTSGD+ ALL+L G + Sbjct: 302 TLSSMIMEDTSGDYKNALLSLVGSD 326 Score = 189 bits (479), Expect = 5e-48, Method: Composition-based stats. Identities = 93/336 (27%), Positives = 155/336 (46%), Gaps = 36/336 (10%) Query: 177 VQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSG 236 D + LY+A + GT+E I +L RS + + + GK + +++ ELSG Sbjct: 23 PDPDAETLYKAMKG-IGTNEQAIIDVLTKRSNTQRQQIAKSFKAQFGKDLTETLKSELSG 81 Query: 237 DFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTK 296 FE+L++A+ + Y A+ L AMKGLGT++ +I I+ SR++ + +I + + Sbjct: 82 KFERLIVAL---MYPPYRYEAKELHDAMKGLGTKEGVIIEILASRTKNQLREIMKAYEED 138 Query: 297 YEKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGT 356 Y SL I+ DTSG ++ L+ L G D F A Sbjct: 139 YGSSLEEDIQADTSGYLERILVCLLQGSRDDVSSFVDPAL-------------------- 178 Query: 357 VRPANDFNPDADAKALRKA-MKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMT 415 DA+ L A K GTDE I I+ RS ++ + ++ + + Sbjct: 179 --------ALQDAQDLYAAGEKIRGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIED 230 Query: 416 DLKSEISGDLARLILGLMMPPAH---YDAKQLKKAMEGAGTDEKALIEILATRTNAEIRA 472 +KSE G L +L ++ + Y A++L AM+GAGT + LI + +R+ ++ Sbjct: 231 SIKSETHGSLEEAMLTVVKCTQNLHSYFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNL 290 Query: 473 INEAYKEDYHKSLEDALSSDTSGHFRRILISLATGH 508 I +K+ Y K+L + DTSG ++ L+SL Sbjct: 291 IKCHFKKMYGKTLSSMIMEDTSGDYKNALLSLVGSD 326 >4X9P-A nrPDB Length = 343 Score = 395 bits (1014), Expect = e-110, Method: Composition-based stats. Identities = 149/318 (46%), Positives = 214/318 (67%), Gaps = 1/318 (0%) Query: 9 KYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGK 68 GS+ + FD +DA + TA+K G D+ I++I+T+RSN QRQ++ +Y+ K Sbjct: 26 SAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKK 85 Query: 69 DLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMH 128 +L + LK L+G E +I+GL++ PA DA E+K ++ G+GTDE LIEI+ SRTN+++ Sbjct: 86 ELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQ 145 Query: 129 QLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREED-DVVSEDLVQQDVQDLYEA 187 ++ YK+ Y+ DLE DI+ DTSG F+K++V L +G R ED V+ +L+ QD +DLY+A Sbjct: 146 EINRVYKEMYKTDLEKDIVSDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDA 205 Query: 188 GELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVK 247 G + GTD ++I I+ RS HL+ VF+ Y + + SI+ E+ GD E L +V+ Sbjct: 206 GVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQ 265 Query: 248 CIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKN 307 CI++ P YFA+RL+ +MKG GTRD LIRIMVSRSE+DML IR F+ KY KSLY I+ Sbjct: 266 CIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQ 325 Query: 308 DTSGEYKKTLLKLSGGDD 325 DT G+Y+K LL L GGDD Sbjct: 326 DTKGDYQKALLYLCGGDD 343 Score = 377 bits (967), Expect = e-104, Method: Composition-based stats. Identities = 148/319 (46%), Positives = 214/319 (67%), Gaps = 4/319 (1%) Query: 355 GTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLM 414 G+V+ +F+ + DA + A+K G DE TI++I+T+RSN QRQ I ++ ++L Sbjct: 29 GSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELA 88 Query: 415 TDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAIN 474 + LKS +SG L +ILGL+ PA YDA +LK +M+G GTDE +LIEI+ +RTN E++ IN Sbjct: 89 SALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEIN 148 Query: 475 EAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIAD 534 YKE Y LE + SDTSG FR+++++LA G R E G +D D Q A ++ + Sbjct: 149 RVYKEMYKTDLEKDIVSDTSGDFRKLMVALAKGRRAEDGSVIDYELID-QDARDLYDAGV 207 Query: 535 TPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIV 594 G ++++I+ RS HL++VF+ + + YD+ +IKKE+ GD+ +AF+ +V Sbjct: 208 KRKGTD---VPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLV 264 Query: 595 QSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIE 654 Q ++NKPL+FAD+LY SMKG GT +K L RIMVSRSE+D+L IR EF +KY KSL+ I+ Sbjct: 265 QCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQ 324 Query: 655 GDTSGDFLKALLALCGGED 673 DT GD+ KALL LCGG+D Sbjct: 325 QDTKGDYQKALLYLCGGDD 343 Score = 178 bits (451), Expect = 7e-45, Method: Composition-based stats. Identities = 95/336 (28%), Positives = 165/336 (49%), Gaps = 36/336 (10%) Query: 177 VQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSG 236 ++D ++ A + K G DE + IL NRS + + + Y + T K + ++++ LSG Sbjct: 39 AERDALNIETAIKTK-GVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSALSG 97 Query: 237 DFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTK 296 E ++L ++K + +Y A L +MKGLGT +++LI I+ SR+ ++ +I +++ Sbjct: 98 HLETVILGLLK---TPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEM 154 Query: 297 YEKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGT 356 Y+ L I +DTSG+++K ++ L+ G G Sbjct: 155 YKTDLEKDIVSDTSGDFRKLMVALAKGRRAEDGSVIDYELI------------------- 195 Query: 357 VRPANDFNPDADAKALRKA-MKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMT 415 D DA+ L A +K GTD I I+T RS Q++ + +KS+ D++ Sbjct: 196 ---------DQDARDLYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLE 246 Query: 416 DLKSEISGDLARLILGL---MMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRA 472 +K E+ GDL L L + Y A +L +M+G GT +K LI I+ +R+ ++ Sbjct: 247 SIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLK 306 Query: 473 INEAYKEDYHKSLEDALSSDTSGHFRRILISLATGH 508 I +K+ Y KSL + DT G +++ L+ L G Sbjct: 307 IRSEFKKKYGKSLYYYIQQDTKGDYQKALLYLCGGD 342 >1DM5-A nrPDB Length = 315 Score = 393 bits (1010), Expect = e-109, Method: Composition-based stats. Identities = 141/313 (45%), Positives = 210/313 (67%) Query: 10 YRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKD 69 +G++ F+ +DAE L AMKG G+D+++I I+ +RSN QRQ++ Y +L+GK Sbjct: 2 VQGTVKPHASFNSREDAETLRKAMKGIGTDEKSITHILATRSNAQRQQIKTDYTTLFGKH 61 Query: 70 LIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQ 129 L +LK EL+G +E + L+R P A+++ A+ G+GTD+ LI+IL +++N Q+H Sbjct: 62 LEDELKSELSGNYEAAALALLRKPDEFLAEQLHAAMKGLGTDKNALIDILCTQSNAQIHA 121 Query: 130 LVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGE 189 + AA+K Y+ DLE +II +TSG+FQ++LV +LQG R+ED+ V+ +D +Y+AGE Sbjct: 122 IKAAFKLLYKEDLEKEIISETSGNFQRLLVSMLQGGRKEDEPVNAAHAAEDAAAIYQAGE 181 Query: 190 LKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCI 249 + GTDE++F +L RS L +F EY K + K I +I E SGD + +LA+VK + Sbjct: 182 GQIGTDESRFNAVLATRSYPQLHQIFHEYSKISNKTILQAIENEFSGDIKNGLLAIVKSV 241 Query: 250 RSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDT 309 + YFAERL AMKGLGT D TLIRI+VSRSE+D+ +I+E F+ Y KSLY I +D Sbjct: 242 ENRFAYFAERLHHAMKGLGTSDKTLIRILVSRSEIDLANIKETFQAMYGKSLYEFIADDC 301 Query: 310 SGEYKKTLLKLSG 322 SG+YK LL+++G Sbjct: 302 SGDYKDLLLQITG 314 Score = 379 bits (974), Expect = e-105, Method: Composition-based stats. Identities = 143/318 (44%), Positives = 207/318 (65%), Gaps = 5/318 (1%) Query: 353 LKGTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRD 412 ++GTV+P FN DA+ LRKAMKG+GTDE +I I+ RSN QRQQI+ + + FG+ Sbjct: 2 VQGTVKPHASFNSREDAETLRKAMKGIGTDEKSITHILATRSNAQRQQIKTDYTTLFGKH 61 Query: 413 LMTDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRA 472 L +LKSE+SG+ L L+ P + A+QL AM+G GTD+ ALI+IL T++NA+I A Sbjct: 62 LEDELKSELSGNYEAAALALLRKPDEFLAEQLHAAMKGLGTDKNALIDILCTQSNAQIHA 121 Query: 473 INEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEI 532 I A+K Y + LE + S+TSG+F+R+L+S+ G R+E D+ A A + I Sbjct: 122 IKAAFKLLYKEDLEKEIISETSGNFQRLLVSMLQGGRKE-----DEPVNAAHAAEDAAAI 176 Query: 533 ADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVA 592 G + E+RF +L TRSYP L ++F E+ K++N + I+ E SGD+++ +A Sbjct: 177 YQAGEGQIGTDESRFNAVLATRSYPQLHQIFHEYSKISNKTILQAIENEFSGDIKNGLLA 236 Query: 593 IVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQA 652 IV+SV+N+ +FA++L+ +MKG GT +KTL RI+VSRSEIDL NI+ F Y KSL++ Sbjct: 237 IVKSVENRFAYFAERLHHAMKGLGTSDKTLIRILVSRSEIDLANIKETFQAMYGKSLYEF 296 Query: 653 IEGDTSGDFLKALLALCG 670 I D SGD+ LL + G Sbjct: 297 IADDCSGDYKDLLLQITG 314 Score = 181 bits (460), Expect = 7e-46, Method: Composition-based stats. Identities = 94/331 (28%), Positives = 163/331 (49%), Gaps = 37/331 (11%) Query: 178 QQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGD 237 ++D + L +A + GTDE +IL RS + + +Y GK +E ++ ELSG+ Sbjct: 15 REDAETLRKAMKG-IGTDEKSITHILATRSNAQRQQIKTDYTTLFGKHLEDELKSELSGN 73 Query: 238 FEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKY 297 +E LA+ +R E+ AE+L AMKGLGT N LI I+ ++S + I+ F+ Y Sbjct: 74 YEAAALAL---LRKPDEFLAEQLHAAMKGLGTDKNALIDILCTQSNAQIHAIKAAFKLLY 130 Query: 298 EKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTV 357 ++ L I ++TSG +++ L+ + G Sbjct: 131 KEDLEKEIISETSGNFQRLLVSMLQGGRKED----------------------------- 161 Query: 358 RPANDFNPDADAKALRKAMKG-LGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTD 416 P N + DA A+ +A +G +GTDE ++ RS Q QI + + ++ Sbjct: 162 EPVNAAHAAEDAAAIYQAGEGQIGTDESRFNAVLATRSYPQLHQIFHEYSKISNKTILQA 221 Query: 417 LKSEISGDLARLILGLMMP---PAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAI 473 +++E SGD+ +L ++ Y A++L AM+G GT +K LI IL +R+ ++ I Sbjct: 222 IENEFSGDIKNGLLAIVKSVENRFAYFAERLHHAMKGLGTSDKTLIRILVSRSEIDLANI 281 Query: 474 NEAYKEDYHKSLEDALSSDTSGHFRRILISL 504 E ++ Y KSL + ++ D SG ++ +L+ + Sbjct: 282 KETFQAMYGKSLYEFIADDCSGDYKDLLLQI 312 Score = 100 bits (250), Expect = 2e-21, Method: Composition-based stats. Identities = 40/153 (26%), Positives = 78/153 (50%), Gaps = 10/153 (6%) Query: 519 AREDAQVAAEILEIADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTI 578 +REDA+ + ++ + E IL TRS +++ ++ + +E + Sbjct: 14 SREDAETLRKAMKG-------IGTDEKSITHILATRSNAQRQQIKTDYTTLFGKHLEDEL 66 Query: 579 KKEMSGDVRDAFVAIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIR 638 K E+SG+ A +A+++ F A++L+ +MKG GTD+ L I+ ++S + I+ Sbjct: 67 KSELSGNYEAAALALLR---KPDEFLAEQLHAAMKGLGTDKNALIDILCTQSNAQIHAIK 123 Query: 639 REFIEKYDKSLHQAIEGDTSGDFLKALLALCGG 671 F Y + L + I +TSG+F + L+++ G Sbjct: 124 AAFKLLYKEDLEKEIISETSGNFQRLLVSMLQG 156 >6B3I-A nrPDB Length = 343 Score = 381 bits (978), Expect = e-106, Method: Composition-based stats. Identities = 144/320 (45%), Positives = 217/320 (67%), Gaps = 4/320 (1%) Query: 6 QGAKYRGSIHDFP----GFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQS 61 QGA G+ H GFD ++DA+ L A KG G+++ AI++I++ R++ +RQ++ Q Sbjct: 23 QGAMEMGNRHAKASSPQGFDVDRDAKKLNKACKGMGTNEAAIIEILSGRTSDERQQIKQK 82 Query: 62 YKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILAS 121 YK+ YGK+L LK EL+G FE+ + L+ P+ A++++ A+ G+GTDE LIE+L + Sbjct: 83 YKATYGKELEEVLKSELSGNFEKTALALLDHPSEYAARQLQKAMKGLGTDESVLIEVLCT 142 Query: 122 RTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDV 181 RTN+++ + AY+ ++R LE+D+ GDTSG+ +K+LV LLQ R E D V +DL QD Sbjct: 143 RTNKEIIAIKEAYQRLFDRSLESDVKGDTSGNLKKILVSLLQANRNEGDDVDKDLAGQDA 202 Query: 182 QDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKL 241 +DLY+AGE +WGTDE F +L RS + LR F Y GK IE +I E SGD +K Sbjct: 203 KDLYDAGEGRWGTDELAFNEVLAKRSYKQLRATFQAYQILIGKDIEEAIEEETSGDLQKA 262 Query: 242 MLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSL 301 L +V+C + +YFAERL+K+MKG GT + TLIRI+V+R+E+D+ I+ F+ KY+KSL Sbjct: 263 YLTLVRCAQDCEDYFAERLYKSMKGAGTDEETLIRIIVTRAEVDLQGIKAKFQEKYQKSL 322 Query: 302 YSMIKNDTSGEYKKTLLKLS 321 M+++DTSG+++K L+ L Sbjct: 323 SDMVRSDTSGDFRKLLVALL 342 Score = 355 bits (912), Expect = 3e-98, Method: Composition-based stats. Identities = 141/309 (45%), Positives = 207/309 (66%), Gaps = 7/309 (2%) Query: 362 DFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEI 421 F+ D DAK L KA KG+GT+E II+I++ R++ +RQQI+Q +K+ +G++L LKSE+ Sbjct: 40 GFDVDRDAKKLNKACKGMGTNEAAIIEILSGRTSDERQQIKQKYKATYGKELEEVLKSEL 99 Query: 422 SGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDY 481 SG+ + L L+ P+ Y A+QL+KAM+G GTDE LIE+L TRTN EI AI EAY+ + Sbjct: 100 SGNFEKTALALLDHPSEYAARQLQKAMKGLGTDESVLIEVLCTRTNKEIIAIKEAYQRLF 159 Query: 482 HKSLEDALSSDTSGHFRRILISLATGHREEGGE-NLDQAREDAQVAAEILEIADTPSGDK 540 +SLE + DTSG+ ++IL+SL +R EG + + D A +DA+ ++ D G Sbjct: 160 DRSLESDVKGDTSGNLKKILVSLLQANRNEGDDVDKDLAGQDAK------DLYDAGEGRW 213 Query: 541 TSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNK 600 + E F +L RSY LR FQ + + D+E I++E SGD++ A++ +V+ ++ Sbjct: 214 GTDELAFNEVLAKRSYKQLRATFQAYQILIGKDIEEAIEEETSGDLQKAYLTLVRCAQDC 273 Query: 601 PLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGD 660 +FA++LYKSMKGAGTDE+TL RI+V+R+E+DL I+ +F EKY KSL + DTSGD Sbjct: 274 EDYFAERLYKSMKGAGTDEETLIRIIVTRAEVDLQGIKAKFQEKYQKSLSDMVRSDTSGD 333 Query: 661 FLKALLALC 669 F K L+AL Sbjct: 334 FRKLLVALL 342 Score = 205 bits (521), Expect = 5e-53, Method: Composition-based stats. Identities = 111/333 (33%), Positives = 176/333 (52%), Gaps = 37/333 (11%) Query: 177 VQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSG 236 V +D + L +A + GT+EA I IL R+ + + +Y T GK +E ++ ELSG Sbjct: 43 VDRDAKKLNKACKG-MGTNEAAIIEILSGRTSDERQQIKQKYKATYGKELEEVLKSELSG 101 Query: 237 DFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTK 296 +FEK LA+ + EY A +L KAMKGLGT ++ LI ++ +R+ +++ I+E ++ Sbjct: 102 NFEKTALAL---LDHPSEYAARQLQKAMKGLGTDESVLIEVLCTRTNKEIIAIKEAYQRL 158 Query: 297 YEKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGT 356 +++SL S +K DTSG KK L+ L + + + A Sbjct: 159 FDRSLESDVKGDTSGNLKKILVSLLQANRNEGDDVDKDLAG------------------- 199 Query: 357 VRPANDFNPDADAKALRKAMKG-LGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMT 415 DAK L A +G GTDE +++ RS Q + Q ++ G+D+ Sbjct: 200 ----------QDAKDLYDAGEGRWGTDELAFNEVLAKRSYKQLRATFQAYQILIGKDIEE 249 Query: 416 DLKSEISGDLARLILGLMM---PPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRA 472 ++ E SGDL + L L+ Y A++L K+M+GAGTDE+ LI I+ TR +++ Sbjct: 250 AIEEETSGDLQKAYLTLVRCAQDCEDYFAERLYKSMKGAGTDEETLIRIIVTRAEVDLQG 309 Query: 473 INEAYKEDYHKSLEDALSSDTSGHFRRILISLA 505 I ++E Y KSL D + SDTSG FR++L++L Sbjct: 310 IKAKFQEKYQKSLSDMVRSDTSGDFRKLLVALL 342 >4MDV-A nrPDB Length = 375 Score = 365 bits (938), Expect = e-101, Method: Composition-based stats. Identities = 121/340 (35%), Positives = 198/340 (58%), Gaps = 22/340 (6%) Query: 6 QGAKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSL 65 G YR +I GF + DAE L+ +MKG G+++ AI++I+ R+N +RQE+CQSYKSL Sbjct: 22 HGKHYRPTIKPTTGFSASADAERLHRSMKGPGTNELAIINILARRTNYERQEICQSYKSL 81 Query: 66 YGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNE 125 Y +DL DLK + +G F +++ L+ Y AK + A+ G+GT+++ LIEI + N+ Sbjct: 82 YKQDLKDDLKSDTSGDFRKVLCQLIVDTPYMLAKSLYYAMKGLGTNDRVLIEIFTTLWND 141 Query: 126 QMHQLVAAYKDAYE--------RDLEADIIGDTSGHFQKMLVVLLQGTREE--------- 168 +M + AYK + R L D+ +T G ++ L+ L+Q R++ Sbjct: 142 EMKAVADAYKQVLKDKGSEESERSLVTDMKKETCGDYEYALLSLVQAERDDIPILQLKAI 201 Query: 169 -----DDVVSEDLVQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTG 223 + +++ +L + D +DLY +G + GT E + ++ NR+ L L + Y K G Sbjct: 202 PDKGVNSIINHELAEADAKDLYASGAGRVGTSERRITRVICNRTPYQLYLTSEIYFKMYG 261 Query: 224 KPIEASIRGELSGDFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSE 283 K + I E SGD+ KL++AV++ P AE L +M GLGT+D L+R++++RSE Sbjct: 262 KTLLEHIESETSGDYRKLLVAVLRYAIDRPSLIAEWLHDSMAGLGTKDYALMRLLITRSE 321 Query: 284 LDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKTLLKLSGG 323 +D+ DI + + + Y KSL + +K+DTSG+Y++TL L G Sbjct: 322 IDLQDIMDAYESIYGKSLLNAVKDDTSGDYRRTLCVLMGE 361 Score = 342 bits (876), Expect = 4e-94, Method: Composition-based stats. Identities = 112/337 (33%), Positives = 185/337 (54%), Gaps = 21/337 (6%) Query: 354 KGTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDL 413 + T++P F+ ADA+ L ++MKG GT+E II+I+ R+N +RQ+I Q++KS + +DL Sbjct: 27 RPTIKPTTGFSASADAERLHRSMKGPGTNELAIINILARRTNYERQEICQSYKSLYKQDL 86 Query: 414 MTDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAI 473 DLKS+ SGD +++ L++ + AK L AM+G GT+++ LIEI T N E++A+ Sbjct: 87 KDDLKSDTSGDFRKVLCQLIVDTPYMLAKSLYYAMKGLGTNDRVLIEIFTTLWNDEMKAV 146 Query: 474 NEAYKE--------DYHKSLEDALSSDTSGHFRRILISLATGHREE-----------GGE 514 +AYK+ + +SL + +T G + L+SL R++ G Sbjct: 147 ADAYKQVLKDKGSEESERSLVTDMKKETCGDYEYALLSLVQAERDDIPILQLKAIPDKGV 206 Query: 515 NLDQAREDAQVAAEILEIADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDV 574 N E A+ A+ ++ + +G + E R ++C R+ L + + KM + Sbjct: 207 NSIINHELAEADAK--DLYASGAGRVGTSERRITRVICNRTPYQLYLTSEIYFKMYGKTL 264 Query: 575 EHTIKKEMSGDVRDAFVAIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDL 634 I+ E SGD R VA+++ ++P A+ L+ SM G GT + L R++++RSEIDL Sbjct: 265 LEHIESETSGDYRKLLVAVLRYAIDRPSLIAEWLHDSMAGLGTKDYALMRLLITRSEIDL 324 Query: 635 LNIRREFIEKYDKSLHQAIEGDTSGDFLKALLALCGG 671 +I + Y KSL A++ DTSGD+ + L L G Sbjct: 325 QDIMDAYESIYGKSLLNAVKDDTSGDYRRTLCVLMGE 361 Score = 180 bits (457), Expect = 2e-45, Method: Composition-based stats. Identities = 95/342 (27%), Positives = 163/342 (47%), Gaps = 31/342 (9%) Query: 176 LVQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELS 235 D + L+ + + GT+E I IL R+ + + Y + ++ ++ + S Sbjct: 37 SASADAERLHRSMKG-PGTNELAIINILARRTNYERQEICQSYKSLYKQDLKDDLKSDTS 95 Query: 236 GDFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRT 295 GDF K++ ++ TP A+ L+ AMKGLGT D LI I + +M + + ++ Sbjct: 96 GDFRKVLCQLI---VDTPYMLAKSLYYAMKGLGTNDRVLIEIFTTLWNDEMKAVADAYKQ 152 Query: 296 KY--------EKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSA 347 E+SL + +K +T G+Y+ LL L + D + +L A Sbjct: 153 VLKDKGSEESERSLVTDMKKETCGDYEYALLSLVQAERDD------------IPILQLKA 200 Query: 348 VARVELKGTVRPANDFNPDADAKALRKAMKG-LGTDEDTIIDIITHRSNVQRQQIRQTFK 406 + KG N +ADAK L + G +GT E I +I +R+ Q + + Sbjct: 201 IPD---KGVNSIINHELAEADAKDLYASGAGRVGTSERRITRVICNRTPYQLYLTSEIYF 257 Query: 407 SHFGRDLMTDLKSEISGDLARLILGLMM---PPAHYDAKQLKKAMEGAGTDEKALIEILA 463 +G+ L+ ++SE SGD +L++ ++ A+ L +M G GT + AL+ +L Sbjct: 258 KMYGKTLLEHIESETSGDYRKLLVAVLRYAIDRPSLIAEWLHDSMAGLGTKDYALMRLLI 317 Query: 464 TRTNAEIRAINEAYKEDYHKSLEDALSSDTSGHFRRILISLA 505 TR+ +++ I +AY+ Y KSL +A+ DTSG +RR L L Sbjct: 318 TRSEIDLQDIMDAYESIYGKSLLNAVKDDTSGDYRRTLCVLM 359 Score = 145 bits (366), Expect = 6e-35, Method: Composition-based stats. Identities = 89/377 (23%), Positives = 156/377 (41%), Gaps = 88/377 (23%) Query: 257 AERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKT 316 AERL ++MKG GT + +I I+ R+ + +I + +++ Y++ L +K+DTSG+++K Sbjct: 42 AERLHRSMKGPGTNELAIINILARRTNYERQEICQSYKSLYKQDLKDDLKSDTSGDFRKV 101 Query: 317 LLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPANDFNPDADAKALRKAM 376 L +L P AK+L AM Sbjct: 102 LCQLIVD----------------------------------------TPYMLAKSLYYAM 121 Query: 377 KGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFG--------RDLMTDLKSEISGDLARL 428 KGLGT++ +I+I T N + + + +K R L+TD+K E GD Sbjct: 122 KGLGTNDRVLIEIFTTLWNDEMKAVADAYKQVLKDKGSEESERSLVTDMKKETCGDYEYA 181 Query: 429 ILGLMM-------------------------PPAHYDAKQLKKAMEG-AGTDEKALIEIL 462 +L L+ A DAK L + G GT E+ + ++ Sbjct: 182 LLSLVQAERDDIPILQLKAIPDKGVNSIINHELAEADAKDLYASGAGRVGTSERRITRVI 241 Query: 463 ATRTNAEIRAINEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQARED 522 RT ++ +E Y + Y K+L + + S+TSG +R++L+++ A + Sbjct: 242 CNRTPYQLYLTSEIYFKMYGKTLLEHIESETSGDYRKLLVAVLR-----------YAIDR 290 Query: 523 AQVAAEILEIADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEM 582 + AE L + G K M +L TRS L+ + + + + + +K + Sbjct: 291 PSLIAEWLHDSMAGLGTKDY---ALMRLLITRSEIDLQDIMDAYESIYGKSLLNAVKDDT 347 Query: 583 SGDVRDAFVAIVQSVKN 599 SGD R ++ + N Sbjct: 348 SGDYRRTLCVLMGEIYN 364 Score = 115 bits (287), Expect = 8e-26, Method: Composition-based stats. Identities = 58/264 (21%), Positives = 122/264 (46%), Gaps = 43/264 (16%) Query: 26 AEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYG--------KDLIADLKYE 77 A++LY AMKG G++ +++I T+ N + + V +YK + + L+ D+K E Sbjct: 114 AKSLYYAMKGLGTNDRVLIEIFTTLWNDEMKAVADAYKQVLKDKGSEESERSLVTDMKKE 173 Query: 78 LTGKFERLIVGLMR-------------------------PPAYCDAKEIKDAISG-IGTD 111 G +E ++ L++ A DAK++ + +G +GT Sbjct: 174 TCGDYEYALLSLVQAERDDIPILQLKAIPDKGVNSIINHELAEADAKDLYASGAGRVGTS 233 Query: 112 EKCLIEILASRTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDV 171 E+ + ++ +RT Q++ Y Y + L I +TSG ++K+LV +L+ + + Sbjct: 234 ERRITRVICNRTPYQLYLTSEIYFKMYGKTLLEHIESETSGDYRKLLVAVLRYAIDRPSL 293 Query: 172 VSEDLVQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIR 231 + + L+++ GT + + +L RS+ L+ + D Y GK + +++ Sbjct: 294 I--------AEWLHDSMAG-LGTKDYALMRLLITRSEIDLQDIMDAYESIYGKSLLNAVK 344 Query: 232 GELSGDFEKLMLAVVKCIRSTPEY 255 + SGD+ + + ++ I + + Sbjct: 345 DDTSGDYRRTLCVLMGEIYNQQQL 368 Score = 81.6 bits (200), Expect = 1e-15, Method: Composition-based stats. Identities = 33/140 (23%), Positives = 61/140 (43%), Gaps = 11/140 (7%) Query: 541 TSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNK 600 + E + IL R+ + + Q + + D++ +K + SGD R Q + + Sbjct: 53 GTNELAIINILARRTNYERQEICQSYKSLYKQDLKDDLKSDTSGDFRKVL---CQLIVDT 109 Query: 601 PLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDK--------SLHQA 652 P A LY +MKG GT+++ L I + ++ + + + SL Sbjct: 110 PYMLAKSLYYAMKGLGTNDRVLIEIFTTLWNDEMKAVADAYKQVLKDKGSEESERSLVTD 169 Query: 653 IEGDTSGDFLKALLALCGGE 672 ++ +T GD+ ALL+L E Sbjct: 170 MKKETCGDYEYALLSLVQAE 189 >3BRX-A nrPDB Length = 317 Score = 352 bits (904), Expect = 2e-97, Method: Composition-based stats. Identities = 90/307 (29%), Positives = 156/307 (50%), Gaps = 1/307 (0%) Query: 16 DFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIADLK 75 ++D E L A G+G+++ I+DI+ R+ QR + ++Y YG+DL+ L Sbjct: 8 PTTVPSVSEDCEQLRKAFSGWGTNEGLIIDILGHRNAEQRNLIRKTYAETYGEDLLKALD 67 Query: 76 YELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVAAYK 135 EL+ FERL++ PA DA +A + + L+EI +R+ Q+ AY Sbjct: 68 KELSNDFERLVLLWALDPAERDALLANEATKRWTSSNQVLMEIACTRSANQLLHARQAYH 127 Query: 136 DAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELKWGTD 195 Y++ LE D+ T+G F K+L+ L+ R E + V+ L + + + L+E K +D Sbjct: 128 ARYKKSLEEDVAHHTTGDFHKLLLPLVSSYRYEGEEVNMTLAKTEAKLLHEKISNKAYSD 187 Query: 196 EAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRSTPEY 255 + I +L RSK + + Y G I ++ + +F L+ + VKC+ +Y Sbjct: 188 D-DVIRVLATRSKAQINATLNHYKNEYGNDINKDLKADPKDEFLALLRSTVKCLVYPEKY 246 Query: 256 FAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKK 315 F + L A+ GT + L R++ +R+E+D+ I + ++ + L I DT G+Y+K Sbjct: 247 FEKVLRLAINRRGTDEGALTRVVCTRAEVDLKVIADEYQRRNSVPLTRAIVKDTHGDYEK 306 Query: 316 TLLKLSG 322 LL L+G Sbjct: 307 LLLVLAG 313 Score = 330 bits (846), Expect = 1e-90, Method: Composition-based stats. Identities = 101/317 (31%), Positives = 162/317 (51%), Gaps = 16/317 (5%) Query: 359 PANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLK 418 P + D + LRKA G GT+E IIDI+ HR+ QR IR+T+ +G DL+ L Sbjct: 8 PTTVPSVSEDCEQLRKAFSGWGTNEGLIIDILGHRNAEQRNLIRKTYAETYGEDLLKALD 67 Query: 419 SEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYK 478 E+S D RL+L + PA DA +A + + + L+EI TR+ ++ +AY Sbjct: 68 KELSNDFERLVLLWALDPAERDALLANEATKRWTSSNQVLMEIACTRSANQLLHARQAYH 127 Query: 479 EDYHKSLEDALSSDTSGHFRRILISLATGHREEGGE-NLDQAREDAQVAAEILEIADTPS 537 Y KSLE+ ++ T+G F ++L+ L + +R EG E N+ A+ +A++ E + Sbjct: 128 ARYKKSLEEDVAHHTTGDFHKLLLPLVSSYRYEGEEVNMTLAKTEAKLLHEKI------- 180 Query: 538 GDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAI---- 593 +K + + +L TRS + + D I K++ D +D F+A+ Sbjct: 181 SNKAYSDDDVIRVLATRSKAQINATLNHYKNEYGND----INKDLKADPKDEFLALLRST 236 Query: 594 VQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAI 653 V+ + +F L ++ GTDE LTR++ +R+E+DL I E+ + L +AI Sbjct: 237 VKCLVYPEKYFEKVLRLAINRRGTDEGALTRVVCTRAEVDLKVIADEYQRRNSVPLTRAI 296 Query: 654 EGDTSGDFLKALLALCG 670 DT GD+ K LL L G Sbjct: 297 VKDTHGDYEKLLLVLAG 313 Score = 145 bits (366), Expect = 6e-35, Method: Composition-based stats. Identities = 83/333 (24%), Positives = 147/333 (44%), Gaps = 36/333 (10%) Query: 176 LVQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELS 235 V +D + L +A WGT+E I ILG+R+ + L+ Y +T G+ + ++ ELS Sbjct: 13 SVSEDCEQLRKAFSG-WGTNEGLIIDILGHRNAEQRNLIRKTYAETYGEDLLKALDKELS 71 Query: 236 GDFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRT 295 DFE+L+L A +A K + + L+ I +RS +L R+ + Sbjct: 72 NDFERLVLLWALDPAERDALLAN---EATKRWTSSNQVLMEIACTRSANQLLHARQAYHA 128 Query: 296 KYEKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKG 355 +Y+KSL + + T+G++ K LL L + A+ Sbjct: 129 RYKKSLEEDVAHHTTGDFHKLLLPLVSSYRYEGEEVNMTLAKT----------------- 171 Query: 356 TVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMT 415 +AK L + + +D +I ++ RS Q +K+ +G D+ Sbjct: 172 ------------EAKLLHEKISNKAYSDDDVIRVLATRSKAQINATLNHYKNEYGNDINK 219 Query: 416 DLKSEISGDLARLI---LGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRA 472 DLK++ + L+ + ++ P Y K L+ A+ GTDE AL ++ TR +++ Sbjct: 220 DLKADPKDEFLALLRSTVKCLVYPEKYFEKVLRLAINRRGTDEGALTRVVCTRAEVDLKV 279 Query: 473 INEAYKEDYHKSLEDALSSDTSGHFRRILISLA 505 I + Y+ L A+ DT G + ++L+ LA Sbjct: 280 IADEYQRRNSVPLTRAIVKDTHGDYEKLLLVLA 312 Score = 132 bits (333), Expect = 4e-31, Method: Composition-based stats. Identities = 78/360 (21%), Positives = 134/360 (37%), Gaps = 57/360 (15%) Query: 81 KFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVAAYKDAYER 140 L V P D ++++ A SG GT+E +I+IL R EQ + + Y + Y Sbjct: 1 HHATLTVPTTVPSVSEDCEQLRKAFSGWGTNEGLIIDILGHRNAEQRNLIRKTYAETYGE 60 Query: 141 DLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELKWGTDEAQFI 200 DL + + S F++++++ D ++D EA +W + + Sbjct: 61 DLLKALDKELSNDFERLVLLWA-----------LDPAERDALLANEA-TKRWTSSNQVLM 108 Query: 201 YILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRSTPEYF---- 256 I RS L Y K +E + +GDF KL+L +V R E Sbjct: 109 EIACTRSANQLLHARQAYHARYKKSLEEDVAHHTTGDFHKLLLPLVSSYRYEGEEVNMTL 168 Query: 257 ----AERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGE 312 A+ L + + D+ +IR++ +RS+ + ++ +Y + I D + Sbjct: 169 AKTEAKLLHEKISNKAYSDDDVIRVLATRSKAQINATLNHYKNEYG----NDINKDLKAD 224 Query: 313 YKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPANDFNPDADAKAL 372 K L L R +K V P F K L Sbjct: 225 PKDEFLALL----------------------------RSTVKCLVYPEKYFE-----KVL 251 Query: 373 RKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARLILGL 432 R A+ GTDE + ++ R+ V + I ++ L + + GD +L+L L Sbjct: 252 RLAINRRGTDEGALTRVVCTRAEVDLKVIADEYQRRNSVPLTRAIVKDTHGDYEKLLLVL 311 Score = 122 bits (305), Expect = 6e-28, Method: Composition-based stats. Identities = 71/354 (20%), Positives = 131/354 (37%), Gaps = 65/354 (18%) Query: 257 AERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKT 316 E+L KA G GT + +I I+ R+ IR+ + Y + L + + S ++++ Sbjct: 18 CEQLRKAFSGWGTNEGLIIDILGHRNAEQRNLIRKTYAETYGEDLLKALDKELSNDFERL 77 Query: 317 LLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPANDFNPDADAKALRKAM 376 +L +W L + DA +A Sbjct: 78 VL-----------------------LWALDP-----------------AERDALLANEAT 97 Query: 377 KGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARLILGLM--- 433 K + +++I RS Q RQ + + + + L D+ +GD +L+L L+ Sbjct: 98 KRWTSSNQVLMEIACTRSANQLLHARQAYHARYKKSLEEDVAHHTTGDFHKLLLPLVSSY 157 Query: 434 --------MPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKSL 485 M A +AK L + + + +I +LATR+ A+I A YK +Y + Sbjct: 158 RYEGEEVNMTLAKTEAKLLHEKISNKAYSDDDVIRVLATRSKAQINATLNHYKNEYGNDI 217 Query: 486 EDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDKTSLET 545 L +D F +L S + ++L +A G E Sbjct: 218 NKDLKADPKDEFLALLRSTVKCLVYPE-----------KYFEKVLRLAINRRGTD---EG 263 Query: 546 RFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKN 599 ++CTR+ L+ + E+ + + + I K+ GD + + V+N Sbjct: 264 ALTRVVCTRAEVDLKVIADEYQRRNSVPLTRAIVKDTHGDYEKLLLVLAGHVEN 317 Score = 113 bits (283), Expect = 2e-25, Method: Composition-based stats. Identities = 59/250 (23%), Positives = 100/250 (40%), Gaps = 25/250 (10%) Query: 424 DLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHK 483 A L + +P D +QL+KA G GT+E +I+IL R + I + Y E Y + Sbjct: 1 HHATLTVPTTVPSVSEDCEQLRKAFSGWGTNEGLIIDILGHRNAEQRNLIRKTYAETYGE 60 Query: 484 SLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDKTSL 543 L AL + S F R+++ A LD A DA +A E + TS Sbjct: 61 DLLKALDKELSNDFERLVLLWA----------LDPAERDALLANEATK-------RWTSS 103 Query: 544 ETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVK----- 598 M I CTRS L Q + +E + +GD + +V S + Sbjct: 104 NQVLMEIACTRSANQLLHARQAYHARYKKSLEEDVAHHTTGDFHKLLLPLVSSYRYEGEE 163 Query: 599 ---NKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEG 655 A L++ + + + R++ +RS+ + + +Y +++ ++ Sbjct: 164 VNMTLAKTEAKLLHEKISNKAYSDDDVIRVLATRSKAQINATLNHYKNEYGNDINKDLKA 223 Query: 656 DTSGDFLKAL 665 D +FL L Sbjct: 224 DPKDEFLALL 233 Score = 108 bits (270), Expect = 7e-24, Method: Composition-based stats. Identities = 56/241 (23%), Positives = 107/241 (44%), Gaps = 20/241 (8%) Query: 22 PNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIADLKYELTGK 81 +DA A K + S + +++I +RS Q Q+Y + Y K L D+ + TG Sbjct: 86 AERDALLANEATKRWTSSNQVLMEIACTRSANQLLHARQAYHARYKKSLEEDVAHHTTGD 145 Query: 82 FERLIVGLMR-----------PPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQL 130 F +L++ L+ A +AK + + IS + +I +LA+R+ Q++ Sbjct: 146 FHKLLLPLVSSYRYEGEEVNMTLAKTEAKLLHEKISNKAYSDDDVIRVLATRSKAQINAT 205 Query: 131 VAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGEL 190 + YK+ Y D+ D+ D F +L ++ + + L Sbjct: 206 LNHYKNEYGNDINKDLKADPKDEFLALLRSTVKCLVYPEKYFEKVLRLA---------IN 256 Query: 191 KWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIR 250 + GTDE ++ R++ L+++ DEY + P+ +I + GD+EKL+L + + Sbjct: 257 RRGTDEGALTRVVCTRAEVDLKVIADEYQRRNSVPLTRAIVKDTHGDYEKLLLVLAGHVE 316 Query: 251 S 251 + Sbjct: 317 N 317 >1YCN-A nrPDB Length = 317 Score = 340 bits (873), Expect = 8e-94, Method: Composition-based stats. Identities = 101/305 (33%), Positives = 163/305 (53%), Gaps = 2/305 (0%) Query: 22 PNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIADLKYELTGK 81 P+ DAE L TA +G+G++++ I+ I+ RS QR+ + Q+Y YG+DL+ L EL+ Sbjct: 13 PSDDAEQLRTAFEGWGTNEDLIISILAHRSAEQRKVIRQAYHETYGEDLLKTLDKELSND 72 Query: 82 FERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVAAYKDAYERD 141 FER I+ P DA +A + + L+E+ +RT+ Q+ AY Y++ Sbjct: 73 FERAILLWTLEPGERDALLANEATKRWTSSNQVLMEVACTRTSTQLLHARQAYHARYKKS 132 Query: 142 LEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELKWGTDEAQFIY 201 LE D+ T+G F+K+LV L+ R E D V+ L +Q+ + ++E + K DE I Sbjct: 133 LEEDVAHHTTGDFRKLLVSLVTSYRYEGDEVNMTLAKQEAKLVHEKIKDKHYNDE-DVIR 191 Query: 202 ILGNRSKQHLRLVFDEYLKTTGKPIEASI-RGELSGDFEKLMLAVVKCIRSTPEYFAERL 260 IL RSK + F+ Y G+ I S+ G+ F L+ + ++C+ YF + L Sbjct: 192 ILSTRSKAQINATFNRYQDDHGEEILKSLEEGDDDDKFLALLRSTIQCLTRPELYFVDVL 251 Query: 261 FKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKTLLKL 320 A+ GT + L RI+ +R+E+D+ I E ++ + L I DT G+Y+K L+ L Sbjct: 252 RSAINKTGTDEGALTRIVTTRAEIDLKVIGEEYQRRNSIPLEKAITKDTRGDYEKMLVAL 311 Query: 321 SGGDD 325 G DD Sbjct: 312 LGEDD 316 Score = 325 bits (832), Expect = 5e-89, Method: Composition-based stats. Identities = 111/318 (34%), Positives = 170/318 (53%), Gaps = 15/318 (4%) Query: 361 NDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSE 420 + P DA+ LR A +G GT+ED II I+ HRS QR+ IRQ + +G DL+ L E Sbjct: 9 SVPAPSDDAEQLRTAFEGWGTNEDLIISILAHRSAEQRKVIRQAYHETYGEDLLKTLDKE 68 Query: 421 ISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKED 480 +S D R IL + P DA +A + + + L+E+ TRT+ ++ +AY Sbjct: 69 LSNDFERAILLWTLEPGERDALLANEATKRWTSSNQVLMEVACTRTSTQLLHARQAYHAR 128 Query: 481 YHKSLEDALSSDTSGHFRRILISLATGHREEGGE-NLDQAREDAQVAAEILEIADTPSGD 539 Y KSLE+ ++ T+G FR++L+SL T +R EG E N+ A+++A++ E ++ D Sbjct: 129 YKKSLEEDVAHHTTGDFRKLLVSLVTSYRYEGDEVNMTLAKQEAKLVHEKIK-------D 181 Query: 540 KTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQ---- 595 K + + IL TRS + F + E +K GD D F+A+++ Sbjct: 182 KHYNDEDVIRILSTRSKAQINATFNRYQDDHG---EEILKSLEEGDDDDKFLALLRSTIQ 238 Query: 596 SVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEG 655 + L+F D L ++ GTDE LTRI+ +R+EIDL I E+ + L +AI Sbjct: 239 CLTRPELYFVDVLRSAINKTGTDEGALTRIVTTRAEIDLKVIGEEYQRRNSIPLEKAITK 298 Query: 656 DTSGDFLKALLALCGGED 673 DT GD+ K L+AL G +D Sbjct: 299 DTRGDYEKMLVALLGEDD 316 Score = 126 bits (317), Expect = 2e-29, Method: Composition-based stats. Identities = 73/352 (20%), Positives = 138/352 (39%), Gaps = 60/352 (17%) Query: 92 PPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVAAYKDAYERDLEADIIGDTS 151 P DA++++ A G GT+E +I ILA R+ EQ + AY + Y DL + + S Sbjct: 11 PAPSDDAEQLRTAFEGWGTNEDLIISILAHRSAEQRKVIRQAYHETYGEDLLKTLDKELS 70 Query: 152 GHFQKMLV--VLLQGTREEDDVVSEDLVQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQ 209 F++ ++ L G R+ L+ + +W + + + R+ Sbjct: 71 NDFERAILLWTLEPGERD-------ALLANEA-------TKRWTSSNQVLMEVACTRTST 116 Query: 210 HLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRST--------PEYFAERLF 261 L Y K +E + +GDF KL++++V R + A+ + Sbjct: 117 QLLHARQAYHARYKKSLEEDVAHHTTGDFRKLLVSLVTSYRYEGDEVNMTLAKQEAKLVH 176 Query: 262 KAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKTLLKLS 321 + +K D +IRI+ +RS+ + ++ + ++ L L Sbjct: 177 EKIKDKHYNDEDVIRILSTRSKAQINATFNRYQDDHG---------------EEILKSLE 221 Query: 322 GGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPANDFNPDADAKALRKAMKGLGT 381 GDDD + A+ R ++ RP F LR A+ GT Sbjct: 222 EGDDDD----------------KFLALLRSTIQCLTRPELYF-----VDVLRSAINKTGT 260 Query: 382 DEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARLILGLM 433 DE + I+T R+ + + I + ++ L + + GD ++++ L+ Sbjct: 261 DEGALTRIVTTRAEIDLKVIGEEYQRRNSIPLEKAITKDTRGDYEKMLVALL 312 Score = 101 bits (252), Expect = 9e-22, Method: Composition-based stats. Identities = 73/360 (20%), Positives = 141/360 (39%), Gaps = 72/360 (20%) Query: 250 RSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDT 309 P AE+L A +G GT ++ +I I+ RS IR+ + Y + L + + Sbjct: 10 VPAPSDDAEQLRTAFEGWGTNEDLIISILAHRSAEQRKVIRQAYHETYGEDLLKTLDKEL 69 Query: 310 SGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPANDFNPDADA 369 S ++++ +L +W L + DA Sbjct: 70 SNDFERAIL-----------------------LWTLEP-----------------GERDA 89 Query: 370 KALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARLI 429 +A K + ++++ R++ Q RQ + + + + L D+ +GD +L+ Sbjct: 90 LLANEATKRWTSSNQVLMEVACTRTSTQLLHARQAYHARYKKSLEEDVAHHTTGDFRKLL 149 Query: 430 LGLM-----------MPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYK 478 + L+ M A +AK + + ++ +++ +I IL+TR+ A+I A Y+ Sbjct: 150 VSLVTSYRYEGDEVNMTLAKQEAKLVHEKIKDKHYNDEDVIRILSTRSKAQINATFNRYQ 209 Query: 479 EDYH----KSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIAD 534 +D+ KSLE+ D F +L S +D +L A Sbjct: 210 DDHGEEILKSLEE---GDDDDKFLALLRSTIQCLTRPELYFVD-----------VLRSAI 255 Query: 535 TPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIV 594 +G E I+ TR+ L+ + +E+ + + +E I K+ GD VA++ Sbjct: 256 NKTGTD---EGALTRIVTTRAEIDLKVIGEEYQRRNSIPLEKAITKDTRGDYEKMLVALL 312 >1DK5-A nrPDB Length = 322 Score = 333 bits (854), Expect = 1e-91, Method: Composition-based stats. Identities = 92/311 (29%), Positives = 161/311 (51%), Gaps = 5/311 (1%) Query: 18 PGFDPN--QDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIADLK 75 P P+ +D E L +A KG+G++++ I+ I+ R+ QR+ + Q+Y +G+DL+ +L Sbjct: 15 PAHVPSAAEDCEQLRSAFKGWGTNEKLIISILAHRTAAQRKLIRQTYAETFGEDLLKELD 74 Query: 76 YELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVAAYK 135 ELT FE+L++ P+ DA K+A L+E+ +R+ +++ AY Sbjct: 75 RELTHDFEKLVLVWTLDPSERDAHLAKEATKRWTKSNFVLVELACTRSPKELVLAREAYH 134 Query: 136 DAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELKWGTD 195 Y++ LE D+ T+G +K+LV L+ R + V L + + + L+E K +D Sbjct: 135 ARYKKSLEEDVAYHTTGDHRKLLVPLVSSYRYGGEEVDLRLAKAESKILHEKISDKAYSD 194 Query: 196 EAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRSTPEY 255 + + I IL RSK L + Y G+ I + E +F L+ A +K + Y Sbjct: 195 D-EVIRILATRSKAQLNATLNHYKDEHGEDILKQL--EDGDEFVALLRATIKGLVYPEHY 251 Query: 256 FAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKK 315 F E L A+ GT ++ L R++ +R+E+D+ I + ++ + L I DT G+Y+ Sbjct: 252 FVEVLRDAINRRGTEEDHLTRVIATRAEVDLKIIADEYQKRDSIPLGRAIAKDTRGDYES 311 Query: 316 TLLKLSGGDDD 326 LL L G ++D Sbjct: 312 MLLALLGQEED 322 Score = 309 bits (791), Expect = 3e-84, Method: Composition-based stats. Identities = 100/320 (31%), Positives = 164/320 (51%), Gaps = 18/320 (5%) Query: 359 PANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLK 418 PA+ + D + LR A KG GT+E II I+ HR+ QR+ IRQT+ FG DL+ +L Sbjct: 15 PAHVPSAAEDCEQLRSAFKGWGTNEKLIISILAHRTAAQRKLIRQTYAETFGEDLLKELD 74 Query: 419 SEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYK 478 E++ D +L+L + P+ DA K+A + L+E+ TR+ E+ EAY Sbjct: 75 RELTHDFEKLVLVWTLDPSERDAHLAKEATKRWTKSNFVLVELACTRSPKELVLAREAYH 134 Query: 479 EDYHKSLEDALSSDTSGHFRRILISLATGHREEGGE-NLDQAREDAQVAAEILEIADTPS 537 Y KSLE+ ++ T+G R++L+ L + +R G E +L A+ ++++ E + Sbjct: 135 ARYKKSLEEDVAYHTTGDHRKLLVPLVSSYRYGGEEVDLRLAKAESKILHEKI------- 187 Query: 538 GDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSV 597 DK + + IL TRS L + D+ ++ D FVA++++ Sbjct: 188 SDKAYSDDEVIRILATRSKAQLNATLNHYKDEHGEDILKQLE------DGDEFVALLRAT 241 Query: 598 KN----KPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAI 653 +F + L ++ GT+E LTR++ +R+E+DL I E+ ++ L +AI Sbjct: 242 IKGLVYPEHYFVEVLRDAINRRGTEEDHLTRVIATRAEVDLKIIADEYQKRDSIPLGRAI 301 Query: 654 EGDTSGDFLKALLALCGGED 673 DT GD+ LLAL G E+ Sbjct: 302 AKDTRGDYESMLLALLGQEE 321 Score = 127 bits (320), Expect = 1e-29, Method: Composition-based stats. Identities = 80/337 (23%), Positives = 146/337 (43%), Gaps = 36/337 (10%) Query: 176 LVQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELS 235 +D + L A + WGT+E I IL +R+ +L+ Y +T G+ + + EL+ Sbjct: 20 SAAEDCEQLRSAFKG-WGTNEKLIISILAHRTAAQRKLIRQTYAETFGEDLLKELDRELT 78 Query: 236 GDFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRT 295 DFEKL+L + A+ +A K + L+ + +RS +++ RE + Sbjct: 79 HDFEKLVLVWTLDPSERDAHLAK---EATKRWTKSNFVLVELACTRSPKELVLAREAYHA 135 Query: 296 KYEKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKG 355 +Y+KSL + T+G+++K L+ L + A+ Sbjct: 136 RYKKSLEEDVAYHTTGDHRKLLVPLVSSYRYGGEEVDLRLAK------------------ 177 Query: 356 TVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMT 415 A++K L + + +D +I I+ RS Q +K G D++ Sbjct: 178 -----------AESKILHEKISDKAYSDDEVIRILATRSKAQLNATLNHYKDEHGEDILK 226 Query: 416 DLK--SEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAI 473 L+ E L I GL+ P HY + L+ A+ GT+E L ++ATR +++ I Sbjct: 227 QLEDGDEFVALLRATIKGLVY-PEHYFVEVLRDAINRRGTEEDHLTRVIATRAEVDLKII 285 Query: 474 NEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHRE 510 + Y++ L A++ DT G + +L++L + Sbjct: 286 ADEYQKRDSIPLGRAIAKDTRGDYESMLLALLGQEED 322 >3CHK-A nrPDB Length = 337 Score = 234 bits (598), Expect = 7e-62, Method: Composition-based stats. Identities = 65/286 (22%), Positives = 125/286 (43%), Gaps = 10/286 (3%) Query: 386 IIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARLILGLMMPPAHYDAKQLK 445 +I+I Q + +++TF++ G L LK +S D L+L L P A + ++ Sbjct: 32 LIEIARSYPPNQLRNMQRTFQAITGTFLDAFLKKHLSKDFESLVLMLYKPRAQLLCELIR 91 Query: 446 KAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKSLEDALSSDTSGHFR--RILIS 503 A +GAGTDEK L+++L T E+R I + Y + Y+ SL D + D + +++ + Sbjct: 92 GATKGAGTDEKCLVDVLLTIETHEVREIRQLYYQLYNDSLGDVVRKDCGDKYMWAKLINA 151 Query: 504 LATGHREEGGENLDQAREDAQVAAEILEIADTPSGDKTSLETRFMTILCTRSYPHLRRVF 563 +ATG R + + ED + + +E G K + ++ I T + R++ Sbjct: 152 VATGDRIP--RDTHELEEDLVLVRKAIET----KGVKKDEVSTWIRIFATYTRADFRQLH 205 Query: 564 QEFIKMTNYD-VEHTIKKEMSGDVRDAFVAIVQSVKNKPLFFADKLYKSMKGAGTDEKTL 622 + + N D + ++ E G AF + + A + + G+G+D L Sbjct: 206 KMYSAKYNGDSLRAGVEDEFQGLDEYAFKLAHDFLYDPCCAAAFSMNVAFAGSGSDSNRL 265 Query: 623 TRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGDFLKALLAL 668 RI + + + + Y ++ + + G + A+ L Sbjct: 266 NRITAMHFR-ECKGCKYYYKKVYGQAFDERCATELKGVYGDAIKLL 310 Score = 189 bits (481), Expect = 3e-48, Method: Composition-based stats. Identities = 64/284 (22%), Positives = 117/284 (41%), Gaps = 11/284 (3%) Query: 43 ILDIITSRSNRQRQEVCQSYKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIK 102 +++I S Q + + ++++++ G L A LK L+ FE L++ L +P A + I+ Sbjct: 32 LIEIARSYPPNQLRNMQRTFQAITGTFLDAFLKKHLSKDFESLVLMLYKPRAQLLCELIR 91 Query: 103 DAISGIGTDEKCLIEILASRTNEQMHQLVAAYKDAYERDLEADIIGDTSGH---FQKMLV 159 A G GTDEKCL+++L + ++ ++ Y Y L D++ G + K++ Sbjct: 92 GATKGAGTDEKCLVDVLLTIETHEVREIRQLYYQLYNDSL-GDVVRKDCGDKYMWAKLIN 150 Query: 160 VLLQGTREEDD--VVSEDLVQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDE 217 + G R D + EDLV V+ E +K + + +I I ++ R + Sbjct: 151 AVATGDRIPRDTHELEEDLVL--VRKAIETKGVKK-DEVSTWIRIFATYTRADFRQLHKM 207 Query: 218 Y-LKTTGKPIEASIRGELSGDFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIR 276 Y K G + A + E G E + A + A G G+ N L R Sbjct: 208 YSAKYNGDSLRAGVEDEFQGLDEYAFKLAHDFLYDPCCAAAFSMNVAFAGSGSDSNRLNR 267 Query: 277 IMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKTLLKL 320 I + + ++ Y ++ + G Y + L Sbjct: 268 ITAMHFR-ECKGCKYYYKKVYGQAFDERCATELKGVYGDAIKLL 310 Score = 140 bits (352), Expect = 3e-33, Method: Composition-based stats. Identities = 69/338 (20%), Positives = 132/338 (39%), Gaps = 52/338 (15%) Query: 195 DEAQ---FIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRS 251 DE++ I I + LR + + TG ++A ++ LS DFE L+L + K Sbjct: 25 DESKRLDLIEIARSYPPNQLRNMQRTFQAITGTFLDAFLKKHLSKDFESLVLMLYK---P 81 Query: 252 TPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSG 311 + E + A KG GT + L+ ++++ ++ +IR+++ Y SL +++ D Sbjct: 82 RAQLLCELIRGATKGAGTDEKCLVDVLLTIETHEVREIRQLYYQLYNDSLGDVVRKDCGD 141 Query: 312 EYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPANDFNPDADAKA 371 +Y MW + G P + + D Sbjct: 142 KY----------------------------MWA--KLINAVATGDRIPRDTHELEEDLVL 171 Query: 372 LRKAM--KGLGTDE-DTIIDIITHRSNVQRQQIRQTFKSHF-GRDLMTDLKSEISGDLA- 426 +RKA+ KG+ DE T I I + +Q+ + + + + G L ++ E G Sbjct: 172 VRKAIETKGVKKDEVSTWIRIFATYTRADFRQLHKMYSAKYNGDSLRAGVEDEFQGLDEY 231 Query: 427 --RLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKS 484 +L + P A + A G+G+D L I A E + YK+ Y ++ Sbjct: 232 AFKLAHDFLYDPCCAAAFSMNVAFAGSGSDSNRLNRITAMHF-RECKGCKYYYKKVYGQA 290 Query: 485 LEDALSSDTSGHF--------RRILISLATGHREEGGE 514 ++ +++ G + + + L + +G E Sbjct: 291 FDERCATELKGVYGDAIKLLWEPVTVPLLSMDDYQGSE 328 Score = 83.2 bits (204), Expect = 3e-16, Method: Composition-based stats. Identities = 27/129 (20%), Positives = 56/129 (43%), Gaps = 3/129 (2%) Query: 539 DKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVK 598 S + I + LR + + F +T ++ +KK +S D + + + Sbjct: 24 QDESKRLDLIEIARSYPPNQLRNMQRTFQAITGTFLDAFLKKHLSKDFESLVLMLYK--- 80 Query: 599 NKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTS 658 + + + + KGAGTDEK L ++++ ++ IR+ + + Y+ SL + D Sbjct: 81 PRAQLLCELIRGATKGAGTDEKCLVDVLLTIETHEVREIRQLYYQLYNDSLGDVVRKDCG 140 Query: 659 GDFLKALLA 667 ++ A L Sbjct: 141 DKYMWAKLI 149 Score = 57.4 bits (137), Expect = 2e-08, Method: Composition-based stats. Identities = 46/234 (19%), Positives = 83/234 (35%), Gaps = 30/234 (12%) Query: 26 AEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIADLKYELTGKF--E 83 E + A KG G+D++ ++D++ + + +E+ Q Y LY L ++ + K+ Sbjct: 87 CELIRGATKGAGTDEKCLVDVLLTIETHEVREIRQLYYQLYNDSLGDVVRKDCGDKYMWA 146 Query: 84 RLIVGLMR-PPAYCDAKEIKD---------AISGIGTDE-KCLIEILASRTNEQMHQLVA 132 +LI + D E+++ G+ DE I I A+ T QL Sbjct: 147 KLINAVATGDRIPRDTHELEEDLVLVRKAIETKGVKKDEVSTWIRIFATYTRADFRQLHK 206 Query: 133 AYKDAY-ERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELK 191 Y Y L A + + G + + D + ++ AG Sbjct: 207 MYSAKYNGDSLRAGVEDEFQGLDEYAFKL------AHDFLYDPCCAAAFSMNVAFAGS-- 258 Query: 192 WGTDEAQFIYILGNRSKQHLRLVFD---EYLKTTGKPIEASIRGELSGDFEKLM 242 G+D + I + H R Y K G+ + EL G + + Sbjct: 259 -GSDSNRLNRI----TAMHFRECKGCKYYYKKVYGQAFDERCATELKGVYGDAI 307 Score = 54.7 bits (130), Expect = 1e-07, Method: Composition-based stats. Identities = 46/238 (19%), Positives = 87/238 (36%), Gaps = 27/238 (11%) Query: 369 AKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDL--A 426 + +R A KG GTDE ++D++ + ++IRQ + + L ++ + A Sbjct: 87 CELIRGATKGAGTDEKCLVDVLLTIETHEVREIRQLYYQLYNDSLGDVVRKDCGDKYMWA 146 Query: 427 RLILGLMM-PPAHYDAKQLKK---------AMEGAGTDE-KALIEILATRTNAEIRAINE 475 +LI + D +L++ +G DE I I AT T A+ R +++ Sbjct: 147 KLINAVATGDRIPRDTHELEEDLVLVRKAIETKGVKKDEVSTWIRIFATYTRADFRQLHK 206 Query: 476 AYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIADT 535 Y Y+ D+L + F+ + D + AA + +A Sbjct: 207 MYSAKYN---GDSLRAGVEDEFQGL-------DEYAFKLAHDFLYDPCCAAAFSMNVAFA 256 Query: 536 PSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAI 593 SG ++ R I + + + K+ + E+ G DA + Sbjct: 257 GSGSDSN---RLNRITAMH-FRECKGCKYYYKKVYGQAFDERCATELKGVYGDAIKLL 310 Score = 42.3 bits (98), Expect = 6e-04, Method: Composition-based stats. Identities = 30/161 (18%), Positives = 59/161 (36%), Gaps = 8/161 (4%) Query: 8 AKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAI---LDIITSRSNRQRQEVCQSYKS 64 A G + +D + A++ G K+ + + I + + +++ + Y + Sbjct: 151 AVATGDRIPRDTHELEEDLVLVRKAIETKGVKKDEVSTWIRIFATYTRADFRQLHKMYSA 210 Query: 65 LY-GKDLIADLKYELTGKFE---RLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILA 120 Y G L A ++ E G E +L + P A + A +G G+D L I A Sbjct: 211 KYNGDSLRAGVEDEFQGLDEYAFKLAHDFLYDPCCAAAFSMNVAFAGSGSDSNRLNRITA 270 Query: 121 SRTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVL 161 + YK Y + + + G + + +L Sbjct: 271 MHF-RECKGCKYYYKKVYGQAFDERCATELKGVYGDAIKLL 310 >4EVF-A nrPDB Length = 295 Score = 180 bits (456), Expect = 2e-45, Method: Composition-based stats. Identities = 52/206 (25%), Positives = 90/206 (43%), Gaps = 9/206 (4%) Query: 26 AEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIADLKYELTGKFER- 84 A L A+ D+ I I + S R+++ ++Y + YGK+L D+K L G E Sbjct: 8 ANELKQAID--AKDEVQIAFIASEYSAESREKIAKAYVASYGKELPDDIKKALKGGSEES 65 Query: 85 LIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVAAYKDAYERDLEA 144 L++ L A+ I+DA+SG D + + T E H+ VAAY +++ L Sbjct: 66 LLMDLFSDRHEVRAQHIRDALSG-RNDHMAFFDTVILCTPEDWHETVAAYTRMFKKPLVE 124 Query: 145 DIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELKWGTDEAQFIYILG 204 D + D ++ +L++ + V + + Q L +A + K + A I G Sbjct: 125 DFMKDVGR--KEDWCLLMEKWMAHERVSRPGSPEDEAQRLDQAFDQK---NTAYLIDFFG 179 Query: 205 NRSKQHLRLVFDEYLKTTGKPIEASI 230 R + + + GK IE +I Sbjct: 180 TVPSAEYRPIAEAFKAQNGKSIEQAI 205 Score = 72.0 bits (175), Expect = 8e-13, Method: Composition-based stats. Identities = 49/283 (17%), Positives = 92/283 (32%), Gaps = 23/283 (8%) Query: 369 AKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARL 428 A L++A+ DE I I + S R++I + + + +G++L D+K + G Sbjct: 8 ANELKQAIDA--KDEVQIAFIASEYSAESREKIAKAYVASYGKELPDDIKKALKGGSEES 65 Query: 429 ILG-LMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKSLED 487 +L L A+ ++ A+ G D A + + T + AY + K L + Sbjct: 66 LLMDLFSDRHEVRAQHIRDALSGR-NDHMAFFDTVILCTPEDWHETVAAYTRMFKKPLVE 124 Query: 488 ALSSDTSGHFRRILIS---LATGHREEGGENLDQAREDAQVAAEILEIADTPSGDKTSLE 544 D L+ +A G D+A+ Q + Sbjct: 125 DFMKDVGRKEDWCLLMEKWMAHERVSRPGSPEDEAQRLDQAFDQKNTAY----------- 173 Query: 545 TRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNKPLFF 604 + T R + + F +E I + F ++ Sbjct: 174 --LIDFFGTVPSAEYRPIAEAFKAQNGKSIEQAIATIYTKTDYYTFYCAHFALLGMHRLA 231 Query: 605 ADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDK 647 A + + G DEK + RI + +D + + Y Sbjct: 232 AYLINCACNDKG-DEKRMRRI--TGMMVDKCLGAKHAYKIYGD 271 Score = 53.9 bits (128), Expect = 2e-07, Method: Composition-based stats. Identities = 49/291 (16%), Positives = 92/291 (31%), Gaps = 51/291 (17%) Query: 181 VQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEK 240 +L +A + K DE Q +I S + + Y+ + GK + I+ L G E+ Sbjct: 8 ANELKQAIDAK---DEVQIAFIASEYSAESREKIAKAYVASYGKELPDDIKKALKGGSEE 64 Query: 241 LMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKS 300 +L + E A+ + A+ G ++ + D + + ++K Sbjct: 65 SLLMDL--FSDRHEVRAQHIRDALSGR-NDHMAFFDTVILCTPEDWHETVAAYTRMFKKP 121 Query: 301 LYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPA 360 L D G +D W L + + RP Sbjct: 122 LVEDFMKD------------VGRKED----------------WCLLMEKWMAHERVSRPG 153 Query: 361 NDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSE 420 +P+ +A+ L +A T +ID + + + I + FK+ G+ + Sbjct: 154 ---SPEDEAQRLDQAFDQKNT--AYLIDFFGTVPSAEYRPIAEAFKAQNGKSI------- 201 Query: 421 ISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIR 471 + I + +Y A+ G LI E R Sbjct: 202 -----EQAIATIYTKTDYYTFYCAHFALLGMHRLAAYLINCACNDKGDEKR 247 Score = 42.7 bits (99), Expect = 5e-04, Method: Composition-based stats. Identities = 46/236 (19%), Positives = 76/236 (32%), Gaps = 30/236 (12%) Query: 434 MPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKSLEDALSSDT 493 MP A +LK+A++ DE + I + + I +AY Y K L D + Sbjct: 1 MPKVTDIANELKQAIDAK--DEVQIAFIASEYSAESREKIAKAYVASYGKELPDDIKKAL 58 Query: 494 SGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDKTSLETRFMTILCT 553 G L+ R E I D SG + ILCT Sbjct: 59 KGGSEESLLMDLFSDRHEV---------------RAQHIRDALSGRNDHMAFFDTVILCT 103 Query: 554 RSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNK-------PLFFAD 606 + +M + K++ G D + + + + ++ P A Sbjct: 104 --PEDWHETVAAYTRMFKKPLVEDFMKDV-GRKEDWCLLMEKWMAHERVSRPGSPEDEAQ 160 Query: 607 KLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEG-DTSGDF 661 +L ++ T L + + I F + KS+ QAI T D+ Sbjct: 161 RLDQAFDQKNT--AYLIDFFGTVPSAEYRPIAEAFKAQNGKSIEQAIATIYTKTDY 214 >1BO9-A nrPDB Length = 73 Score = 99.0 bits (245), Expect = 5e-21, Method: Composition-based stats. Identities = 32/73 (43%), Positives = 44/73 (60%) Query: 362 DFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEI 421 FNP +D AL KA+ G DE TIIDI+T R+N QRQQI+ + G+ L LK + Sbjct: 1 TFNPSSDVAALHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKAL 60 Query: 422 SGDLARLILGLMM 434 +G L ++L L+ Sbjct: 61 TGHLEEVVLALLK 73 Score = 97.4 bits (241), Expect = 2e-20, Method: Composition-based stats. Identities = 28/73 (38%), Positives = 44/73 (60%) Query: 19 GFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIADLKYEL 78 F+P+ D AL+ A+ G D+ I+DI+T R+N QRQ++ +Y GK L LK L Sbjct: 1 TFNPSSDVAALHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKAL 60 Query: 79 TGKFERLIVGLMR 91 TG E +++ L++ Sbjct: 61 TGHLEEVVLALLK 73 Score = 70.5 bits (171), Expect = 2e-12, Method: Composition-based stats. Identities = 22/67 (32%), Positives = 36/67 (53%) Query: 440 DAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKSLEDALSSDTSGHFRR 499 D L KA+ G DE +I+IL R NA+ + I AY ++ K L++ L +GH Sbjct: 7 DVAALHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLEE 66 Query: 500 ILISLAT 506 ++++L Sbjct: 67 VVLALLK 73 Score = 65.1 bits (157), Expect = 9e-11, Method: Composition-based stats. Identities = 25/71 (35%), Positives = 43/71 (60%), Gaps = 1/71 (1%) Query: 177 VQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSG 236 DV L++A +K G DEA I IL R+ + + YL+ TGKP++ +++ L+G Sbjct: 4 PSSDVAALHKAIMVK-GVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTG 62 Query: 237 DFEKLMLAVVK 247 E+++LA++K Sbjct: 63 HLEEVVLALLK 73 Score = 48.1 bits (113), Expect = 1e-05, Method: Composition-based stats. Identities = 21/67 (31%), Positives = 35/67 (52%) Query: 97 DAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQK 156 D + AI G DE +I+IL R N Q Q+ AAY + L+ + +GH ++ Sbjct: 7 DVAALHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLEE 66 Query: 157 MLVVLLQ 163 +++ LL+ Sbjct: 67 VVLALLK 73 Score = 38.1 bits (87), Expect = 0.011, Method: Composition-based stats. Identities = 15/62 (24%), Positives = 28/62 (45%) Query: 260 LFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKTLLK 319 L KA+ G + T+I I+ R+ I+ + + K L +K +G ++ +L Sbjct: 11 LHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLA 70 Query: 320 LS 321 L Sbjct: 71 LL 72 Score = 37.7 bits (86), Expect = 0.014, Method: Composition-based stats. Identities = 15/62 (24%), Positives = 32/62 (51%) Query: 608 LYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGDFLKALLA 667 L+K++ G DE T+ I+ R+ I+ ++++ K L + ++ +G + +LA Sbjct: 11 LHKAIMVKGVDEATIIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLA 70 Query: 668 LC 669 L Sbjct: 71 LL 72 >2IIC-A nrPDB Length = 310 Score = 68.2 bits (165), Expect = 1e-11, Method: Composition-based stats. Identities = 32/204 (15%), Positives = 76/204 (37%), Gaps = 9/204 (4%) Query: 37 GSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIADLKYELT-GKFERLIVGLMRPPAY 95 ++E ++ + S +R+E+ ++ G + IA LK + G +E ++ Sbjct: 19 AKNEEELVTFTSRWSAEERKELRTQFQDTTGLEFIAFLKKCIKNGPYEDVMALGWDCNIS 78 Query: 96 CDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVAAYKDAYERDLEADIIGDT--SGH 153 IK A+ + D + + +++ T ++ +L AYK+ DL D + + Sbjct: 79 ARVNVIKKAMKNV-NDFRAIHDVVLIATPDERLKLAQAYKEKTGNDLLQDFVDQIPLTSA 137 Query: 154 FQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRL 213 + + ++ R V D + L D + ++ + + Sbjct: 138 ASYLCHLAIRENRTPR-----GSVASDAEVLKHNLIDADEPDHEAVVRLIITSTADEYKE 192 Query: 214 VFDEYLKTTGKPIEASIRGELSGD 237 + + TGK ++ +I + Sbjct: 193 INHRFEVLTGKSVQEAIETRYADK 216 Score = 58.9 bits (141), Expect = 7e-09, Method: Composition-based stats. Identities = 31/202 (15%), Positives = 71/202 (35%), Gaps = 14/202 (6%) Query: 381 TDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEI-SGDLARLILGLMMPPAHY 439 +E+ ++ + S +R+++R F+ G + + LK I +G ++ Sbjct: 20 KNEEELVTFTSRWSAEERKELRTQFQDTTGLEFIAFLKKCIKNGPYEDVMALGWDCNISA 79 Query: 440 DAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKSLEDALSSD--TSGHF 497 +KKAM+ D +A+ +++ T E + +AYKE L + Sbjct: 80 RVNVIKKAMKNV-NDFRAIHDVVLIATPDERLKLAQAYKEKTGNDLLQDFVDQIPLTSAA 138 Query: 498 RRILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDKTSLETRFMTILCTRSYP 557 + +R G A + +++ + ++ T + Sbjct: 139 SYLCHLAIRENRTPRGSVASDAE---VLKHNLIDA-------DEPDHEAVVRLIITSTAD 188 Query: 558 HLRRVFQEFIKMTNYDVEHTIK 579 + + F +T V+ I+ Sbjct: 189 EYKEINHRFEVLTGKSVQEAIE 210 Score = 32.3 bits (72), Expect = 0.72, Method: Composition-based stats. Identities = 26/194 (13%), Positives = 59/194 (30%), Gaps = 6/194 (3%) Query: 118 ILASRTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLV 177 IL ++ E++ + + ++L T F L ++ ED + Sbjct: 16 ILEAKNEEELVTFTSRWSAEERKELRTQFQDTTGLEFIAFLKKCIKNGPYEDVMALGWDC 75 Query: 178 QQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGE---L 234 + +K D ++ + + Y + TG + + Sbjct: 76 NISARVNVIKKAMKNVNDFRAIHDVVLIATPDERLKLAQAYKEKTGNDLLQDFVDQIPLT 135 Query: 235 SGDFEKLMLAVVKCIRSTPEYF--AERL-FKAMKGLGTRDNTLIRIMVSRSELDMLDIRE 291 S LA+ + AE L + ++R++++ + + +I Sbjct: 136 SAASYLCHLAIRENRTPRGSVASDAEVLKHNLIDADEPDHEAVVRLIITSTADEYKEINH 195 Query: 292 IFRTKYEKSLYSMI 305 F KS+ I Sbjct: 196 RFEVLTGKSVQEAI 209 >6HIW-DG nrPDB Length = 631 Score = 31.9 bits (71), Expect = 1.0, Method: Composition-based stats. Identities = 26/143 (18%), Positives = 53/143 (37%), Gaps = 18/143 (12%) Query: 501 LISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDKTSLETRFMTILCTRSYPHLR 560 L ++ATG R EGGE++ A + E + + ++ + +R Sbjct: 489 LRTVATGRRYEGGEDVLSDGAVATSSCEQRRRGTLFA--EGYDFDVWVRLFSL--VQEVR 544 Query: 561 RVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNKPLFFADKLYKSMKGAGTDEK 620 ++F+ ++ E +A + ++ + + M+G G Sbjct: 545 HDMEKFMA---DHTLQCVEPEFE--CWEALLVTLRCALDFCVV-------QMQGGGARGT 592 Query: 621 TLTRIMVSRSEIDLLNIRREFIE 643 R +V R D++ +R E IE Sbjct: 593 E--REVVERLFRDVVALREELIE 613 >3IYJ-F nrPDB Length = 495 Score = 29.6 bits (65), Expect = 4.3, Method: Composition-based stats. Identities = 8/38 (21%), Positives = 17/38 (44%) Query: 3 KPAQGAKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDK 40 + ++G G++ P F+ DAE + + +D Sbjct: 102 QVSRGQPLGGTVTGHPTFNALLDAENVNRKVTTQTTDD 139 Score = 28.5 bits (62), Expect = 9.8, Method: Composition-based stats. Identities = 18/102 (17%), Positives = 37/102 (36%), Gaps = 7/102 (6%) Query: 286 MLDIREIFRTKYEKSLY-SMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWE 344 +L I + Y S+ + ++ +Y+ ++L + A +W Sbjct: 41 LLTIGHPY---YPVSIGAKTVPKVSANQYRVFKIQLPDPNQFALPDRTVHNPSKERLVWA 97 Query: 345 LSAVARVELK---GTVRPANDFNPDADAKALRKAMKGLGTDE 383 + V + GTV FN DA+ + + + TD+ Sbjct: 98 VIGVQVSRGQPLGGTVTGHPTFNALLDAENVNRKVTTQTTDD 139 >1IHU-A nrPDB Length = 589 Score = 29.2 bits (64), Expect = 5.3, Method: Composition-based stats. Identities = 28/169 (16%), Positives = 57/169 (33%), Gaps = 23/169 (13%) Query: 394 SNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARLILGLMMPPAHYDA--KQLKKAMEGA 451 + + ++ RQ G++L K + DL A + A + +++A + Sbjct: 387 PHEETERYRQHVLETKGKELDEAGKRLLEEDLRS---PCTEEIAVFQAFSRVIREAGKR- 442 Query: 452 GTDEKALIEILATRTNAEIRAINEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREE 511 +++ T + AY + K + + GHF ++ L R + Sbjct: 443 ----FVVMDTAPTGHTLLLLDATGAYHREIAKKMGEK------GHFTTPMMLLQDPERTK 492 Query: 512 ----GGENLDQAREDAQVAAEILEIADTPSGDKTSLETRFMTILCTRSY 556 E A + A++ P G + ++I TRS Sbjct: 493 VLLVTLPETTPVLEAANLQADLERAGIHPWGWIINNS---LSIADTRSP 538 >2ZQJ-A nrPDB Length = 417 Score = 29.2 bits (64), Expect = 5.4, Method: Composition-based stats. Identities = 27/121 (22%), Positives = 45/121 (37%), Gaps = 13/121 (10%) Query: 40 KEAILDIITSRSNRQRQEVCQSYKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYCDAK 99 + A + T R RQ + KSL+G + I + + L + LM PP Sbjct: 53 EAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSLMTPPHQKRLA 112 Query: 100 EI-----KDAISGI-GTDEKCLIEILASRTNEQMHQLVAAYKDAYERDLEADIIGDTSGH 153 E+ K A++ DE L E +++ VA Y L+ + + + Sbjct: 113 ELMTEEWKAAVTRWEKADEVVLFE-----EAKEILCRVACYWA--GVPLKETEVKERADD 165 Query: 154 F 154 F Sbjct: 166 F 166 >3AMU-A nrPDB Length = 440 Score = 29.2 bits (64), Expect = 6.5, Method: Composition-based stats. Identities = 20/125 (16%), Positives = 42/125 (33%), Gaps = 9/125 (7%) Query: 524 QVAAEILEIADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMS 583 + + + F L YP +E+ + + +D+++ + + Sbjct: 153 HLRHKKGRGLIGALAAVGAELEDFTLELIAYRYPERFGTEREYDEESFFDMDYELYPQTF 212 Query: 584 GDVRDAFVAIVQSVKNKPLFF--------ADKLYKSMKGAGTDEKTLTRIMVSRSEIDLL 635 +V +V + N P + LYK+M+ T+ I V+ D+ Sbjct: 213 DNVDWCNDVVV-CIPNTPCPVLYGIRGESVEALYKAMESVKTEPVDRRMIFVTNHATDMH 271 Query: 636 NIRRE 640 I E Sbjct: 272 LIGEE 276 >3AU7-A nrPDB Length = 402 Score = 29.2 bits (64), Expect = 6.7, Method: Composition-based stats. Identities = 20/125 (16%), Positives = 42/125 (33%), Gaps = 9/125 (7%) Query: 524 QVAAEILEIADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMS 583 + + + F L YP +E+ + + +D+++ + + Sbjct: 153 HLRHKKGRGLIGALAAVGAELEDFTLELIAYRYPERFGTEREYDEESFFDMDYELYPQTF 212 Query: 584 GDVRDAFVAIVQSVKNKPLFF--------ADKLYKSMKGAGTDEKTLTRIMVSRSEIDLL 635 +V +V + N P + LYK+M+ T+ I V+ D+ Sbjct: 213 DNVDWCNDVVV-CIPNTPCPVLYGIRGESVEALYKAMESVKTEPVDRRMIFVTNHATDMH 271 Query: 636 NIRRE 640 I E Sbjct: 272 LIGEE 276 >5V8F-D nrPDB Length = 529 Score = 28.5 bits (62), Expect = 9.4, Method: Composition-based stats. Identities = 17/66 (25%), Positives = 31/66 (46%), Gaps = 2/66 (3%) Query: 454 DEKALIEILATRTNAEIRAINEAYKEDYHKSLEDALSSDTSGHFRRILISL--ATGHREE 511 E+ I +AT+ +++ I+ + ++ SLE S + F +IL+ L T R E Sbjct: 138 SEQTAINGIATQLEQQLQKIHGSEEKIDDTSLETISSGSLTEVFEKILLLLDSTTKTRNE 197 Query: 512 GGENLD 517 +D Sbjct: 198 DSGEVD 203 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.311 0.135 0.339 Lambda K H 0.267 0.0412 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 24,178,956 Number of Sequences: 36641 Number of extensions: 966624 Number of successful extensions: 4075 Number of sequences better than 10.0: 40 Number of HSP's better than 10.0 without gapping: 53 Number of HSP's successfully gapped in prelim test: 25 Number of HSP's that attempted gapping in prelim test: 2922 Number of HSP's gapped (non-prelim): 225 length of query: 673 length of database: 10,336,785 effective HSP length: 104 effective length of query: 569 effective length of database: 6,526,121 effective search space: 3713362849 effective search space used: 3713362849 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 62 (28.5 bits)