BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P07140 (649 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 1QON-A nrPDB 1229 0.0 4QWW-A nrPDB 424 e-119 6EMI-A nrPDB 416 e-116 5YDJ-A nrPDB 413 e-115 5YDI-A nrPDB 411 e-115 2W6C-X nrPDB 404 e-113 6QAA-A nrPDB 395 e-110 5HQ3-A nrPDB 393 e-109 1Q83-A nrPDB 392 e-109 2X8B-A nrPDB 379 e-105 2WQZ-A nrPDB 235 5e-62 6H18-A nrPDB 231 9e-61 3BIX-A nrPDB 218 6e-57 1AKN-A nrPDB 215 5e-56 5V5V-A nrPDB 211 7e-55 1C7J-A nrPDB 206 2e-53 1K4Y-A nrPDB 185 4e-47 5FV4-A nrPDB 185 5e-47 1MX5-A nrPDB 181 9e-46 5THM-A nrPDB 140 1e-33 1GZ7-A nrPDB 135 6e-32 3RAR-A nrPDB 135 8e-32 1LLF-A nrPDB 130 1e-30 1THG-A nrPDB 126 3e-29 2C7B-A nrPDB 46 5e-05 4WY5-A nrPDB 44 2e-04 2O7R-A nrPDB 41 0.001 2YH2-A nrPDB 39 0.010 5AOA-A nrPDB 37 0.036 5L2P-A nrPDB 36 0.048 4Q3K-A nrPDB 33 0.32 5I8Q-A nrPDB 33 0.44 6ID1-V nrPDB 32 0.73 5XDR-A nrPDB 32 0.82 5D0U-A nrPDB 32 1.2 6AAE-A nrPDB 30 2.3 5G2V-A nrPDB 30 3.1 5LP7-H nrPDB 30 4.5 3EBL-A nrPDB 29 5.9 1RU4-A nrPDB 28 9.5 >1QON-A nrPDB Length = 585 Score = 1229 bits (3180), Expect = 0.0, Method: Compositional matrix adjust. Identities = 585/585 (100%), Positives = 585/585 (100%) Query: 39 VIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDAT 98 VIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDAT Sbjct: 1 VIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDAT 60 Query: 99 GLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNG 158 GLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNG Sbjct: 61 GLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNG 120 Query: 159 KQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQY 218 KQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQY Sbjct: 121 KQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQY 180 Query: 219 RVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAG 278 RVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAG Sbjct: 181 RVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAG 240 Query: 279 SSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTN 338 SSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTN Sbjct: 241 SSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTN 300 Query: 339 PAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDIL 398 PAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDIL Sbjct: 301 PAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDIL 360 Query: 399 MGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWE 458 MGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWE Sbjct: 361 MGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWE 420 Query: 459 GNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLH 518 GNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLH Sbjct: 421 GNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLH 480 Query: 519 GDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDGEEWPNFSKEDPVYY 578 GDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDGEEWPNFSKEDPVYY Sbjct: 481 GDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDGEEWPNFSKEDPVYY 540 Query: 579 IFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWAGTCDGDSGSAS 623 IFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWAGTCDGDSGSAS Sbjct: 541 IFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWAGTCDGDSGSAS 585 >4QWW-A nrPDB Length = 542 Score = 424 bits (1089), Expect = e-119, Method: Compositional matrix adjust. Identities = 231/583 (39%), Positives = 329/583 (56%), Gaps = 64/583 (10%) Query: 38 GVIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDA 97 G L V T +G VRG S+ V V + GIP+A+PP+ +RF +P P +PW VLDA Sbjct: 1 GRAGELKVSTQTGSVRGLSLPVLDGHVSAFLGIPFAEPPLGRMRFLRPEPVKPWQHVLDA 60 Query: 98 TGLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPN 157 T C Q +PGF G E+WNPN +SEDCLY+N+W P+ P Sbjct: 61 TSYKPACYQMVDTSYPGFQGTEMWNPNRGMSEDCLYLNIWVPS---------------PR 105 Query: 158 GKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQ 217 K A P+L+WIYGGGF +G+A+LD+Y+ + NVI+ S Sbjct: 106 PKDA------------------PVLVWIYGGGFYSGAASLDVYDGRFLTYTQNVILVSLS 147 Query: 218 YRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESA 277 YRVGAFGFL L P P EAPGN+GL DQ LA++W+++N H FGGNP +T+FGESA Sbjct: 148 YRVGAFGFLGL-PGSP-----EAPGNMGLLDQRLALQWIQNNIHPFGGNPRAVTVFGESA 201 Query: 278 GSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSE----KAVEIGKALINDCNCNAS 333 G++SV L+S +R L +R ++QSG NAPW+ +T +A +GK L C+ N Sbjct: 202 GAASVGMHLLSTQSRTLFQRAILQSGGPNAPWATVTPAESRGRAALLGKQL--GCHFN-- 257 Query: 334 MLKTNPAHVMSCMRSVDAKTISVQQWN--SYSGILSFPSAPTIDGAFLPADPMTLMKTAD 391 N + ++SC+RS + + + ++W+ Y I FP P IDG F P P ++ + + Sbjct: 258 ----NDSELVSCLRSKNPQELIDEEWSVLPYKSIFRFPFVPVIDGDFFPDTPEAMLSSGN 313 Query: 392 LKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAII 451 K+ +L+G V+DEG+YFL+Y + F KD+ + + R +LE + A +A++ Sbjct: 314 FKETQVLLGVVKDEGSYFLIYG-LPGFSKDNESLISRADFLEGVRMSVPHANDIATDAVV 372 Query: 452 FQYTSWEGNPGYQ-NQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLW 510 QYT W+ + N++ + VGDH CP ++A A+R + V+ Y F HR S LW Sbjct: 373 LQYTDWQDQDNREKNREALDDIVGDHNVICPVVQFANDYAKRNSKVYAYLFDHRASNLLW 432 Query: 511 GEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDGEE---W 567 WMGV HG EIE+ FG PLN+SL Y P E+EL +RM+ FA+TGNP ++ W Sbjct: 433 PPWMGVPHGYEIEFVFGLPLNDSLNYTPQEKELSRRMMRYWANFARTGNPTDPADKSGAW 492 Query: 568 PNFSKEDPVYYIFSTDDKIEKLARGP--LAARCSFWNDYLPKV 608 P ++ P Y +T + LA P A C+FWN +LPK+ Sbjct: 493 PTYTASQPQYVQLNT----QPLATQPSLRAQICAFWNHFLPKL 531 >6EMI-A nrPDB Length = 532 Score = 416 bits (1068), Expect = e-116, Method: Compositional matrix adjust. Identities = 227/574 (39%), Positives = 324/574 (56%), Gaps = 52/574 (9%) Query: 41 DRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGL 100 D +++ T +G VRG ++TV G V + GIPYA+PP+ LRF+KP P W G+ +AT Sbjct: 5 DDIIITTKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQPLTKWSGIWNATKY 64 Query: 101 SATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQ 160 + +C+Q FPGF G E+WNPNT++SEDCLY+NVW PA Sbjct: 65 ANSCMQNIDTSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAP------------------- 105 Query: 161 ADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRV 220 P+N T +++WIYGGGF TG+++L +Y+ +A V VIV S YRV Sbjct: 106 ----------KPKNAT----VMVWIYGGGFQTGTSSLPVYDGKFLARVERVIVVSMNYRV 151 Query: 221 GAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSS 280 GA GFL L P P EAPGN+GL+DQ LA++W++DN AFGG+P +TLFGESAG++ Sbjct: 152 GALGFLAL-PGNP-----EAPGNMGLFDQQLALKWVQDNIAAFGGDPNRVTLFGESAGAA 205 Query: 281 SVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPA 340 SV+ L+SP + L R ++QSG+ NAPW+ M+ E+A L C+ + N Sbjct: 206 SVSLHLLSPGSHPLFTRAILQSGSANAPWAVMSPEEARNRTLNLAKLLGCS----RENET 261 Query: 341 HVMSCMRSVDAKTISVQQ--WNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDIL 398 ++ C+R+ D + I + YS LS PT+DG FL P TL++ K IL Sbjct: 262 EIIKCLRNKDPQEILDNEAFVVPYSTPLSVNFGPTVDGDFLTDMPDTLLELGQFKKTQIL 321 Query: 399 MGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWE 458 +G +DEGT FL+Y F KD+ + + R ++ E + F ++ +E+I+F YT WE Sbjct: 322 VGVNKDEGTAFLVYG-APGFSKDNDSIITRKEFQEGLKVFFPNVSEFGKESILFHYTDWE 380 Query: 459 GNPGYQN-QQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVL 517 +N + + VGD+FF CP E+A+ AE G + ++YYF HR+S W EWMGV+ Sbjct: 381 DEDRPENYRDALAEVVGDYFFICPALEFAKKYAEHGNNAYFYYFEHRSSKLPWPEWMGVM 440 Query: 518 HGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQ---DGEEWPNFSKED 574 HG EIE+ FG PL L Y E L + ++ FAK GNP + + +WP F + Sbjct: 441 HGYEIEFVFGLPLERRLNYTKEEEILSREIMRRWANFAKYGNPNETQNNSTQWPVFKPTE 500 Query: 575 PVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKV 608 Y +T+ ++ A C FWN + PKV Sbjct: 501 QKYLTLNTESS--RIMTKLRAQHCRFWNSFFPKV 532 >5YDJ-A nrPDB Length = 737 Score = 413 bits (1062), Expect = e-115, Method: Compositional matrix adjust. Identities = 224/575 (38%), Positives = 320/575 (55%), Gaps = 52/575 (9%) Query: 41 DRLVVQTSSGPVRGRSVTV-QGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATG 99 D LVV T G +RG +V G++V V+ GIPYA+PPV LRFR P PAE W GVL+ T Sbjct: 164 DPLVVNTDKGRIRGITVDAPSGKKVDVWLGIPYAQPPVGPLRFRHPRPAEKWTGVLNTTT 223 Query: 100 LSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGK 159 +CVQ F F G +WNPNT +SEDCLYINV AP P K Sbjct: 224 PPNSCVQIVDTVFGDFPGATMWNPNTPLSEDCLYINVVAP---------------RPRPK 268 Query: 160 QADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYR 219 A +++WI+GGGF +G+ATLD+Y+ +A+ NVIV S QYR Sbjct: 269 NA------------------AVMLWIFGGGFYSGTATLDVYDHRALASEENVIVVSLQYR 310 Query: 220 VGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGS 279 V + GFL L EAPGN GL+DQ LA+RW++DN H FGG+P +TLFGESAG+ Sbjct: 311 VASLGFLFLG-------TPEAPGNAGLFDQNLALRWVRDNIHRFGGDPSRVTLFGESAGA 363 Query: 280 SSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNP 339 SV+ L+S ++R L +R ++QSG+ APW+ ++ E+A L C K + Sbjct: 364 VSVSLHLLSALSRDLFQRAILQSGSPTAPWALVSREEATLRALRLAEAVGCPHEPSKLSD 423 Query: 340 AHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILM 399 A + C+R D + +W + GI FP P +DGAFL P + + K +IL Sbjct: 424 A--VECLRGKDPHVLVNNEWGTL-GICEFPFVPVVDGAFLDETPQRSLASGRFKKTEILT 480 Query: 400 GNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSW-E 458 G+ +EG YF++Y + K++ + R+++L+ + + A R+AI+F+YT W E Sbjct: 481 GSNTEEGYYFIIYYLTELLRKEEGVTVTREEFLQAVRELNPYVNGAARQAIVFEYTDWTE 540 Query: 459 GNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLH 518 + N+ + + VGD+ FTC NE+AQ AE G +V+ Y +THR+ + W W GV+H Sbjct: 541 PDNPNSNRDALDKMVGDYHFTCNVNEFAQRYAEEGNNVYMYLYTHRSKGNPWPRWTGVMH 600 Query: 519 GDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNP-----AQDGEEWPNFSKE 573 GDEI Y FG+PLN +L Y E++ ++++ FAKTGNP + + EWP + Sbjct: 601 GDEINYVFGEPLNPTLGYTEDEKDFSRKIMRYWSNFAKTGNPNPNTASSEFPEWPKHTAH 660 Query: 574 DPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKV 608 Y + + RGP +C+FW YLP++ Sbjct: 661 GRHYLELGLNTSF--VGRGPRLRQCAFWKKYLPQL 693 >5YDI-A nrPDB Length = 553 Score = 411 bits (1056), Expect = e-115, Method: Compositional matrix adjust. Identities = 224/575 (38%), Positives = 320/575 (55%), Gaps = 52/575 (9%) Query: 41 DRLVVQTSSGPVRGRSVTV-QGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATG 99 D LVV T G +RG +V G++V V+ GIPYA+PPV LRFR P PAE W GVL+ T Sbjct: 3 DPLVVNTDKGRIRGITVDAPSGKKVDVWLGIPYAQPPVGPLRFRHPRPAEKWTGVLNTTT 62 Query: 100 LSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGK 159 +CVQ F F G +WNPNT +SEDCLYINV AP P K Sbjct: 63 PPNSCVQIVDTVFGDFPGATMWNPNTPLSEDCLYINVVAP---------------RPRPK 107 Query: 160 QADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYR 219 A +++WI+GGGF +G+ATLD+Y+ +A+ NVIV S QYR Sbjct: 108 NAA------------------VMLWIFGGGFYSGTATLDVYDHRALASEENVIVVSLQYR 149 Query: 220 VGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGS 279 V + GFL L EAPGN GL+DQ LA+RW++DN H FGG+P +TLFGESAG+ Sbjct: 150 VASLGFLFLG-------TPEAPGNAGLFDQNLALRWVRDNIHRFGGDPSRVTLFGESAGA 202 Query: 280 SSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNP 339 SV+ L+S ++R L +R ++QSG+ APW+ ++ E+A L C K + Sbjct: 203 VSVSLHLLSALSRDLFQRAILQSGSPTAPWALVSREEATLRALRLAEAVGCPHEPSKLSD 262 Query: 340 AHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILM 399 A + C+R D + +W + GI FP P +DGAFL P + + K +IL Sbjct: 263 A--VECLRGKDPHVLVNNEWGTL-GICEFPFVPVVDGAFLDETPQRSLASGRFKKTEILT 319 Query: 400 GNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSW-E 458 G+ +EG YF++Y + K++ + R+++L+ + + A R+AI+F+YT W E Sbjct: 320 GSNTEEGYYFIIYYLTELLRKEEGVTVTREEFLQAVRELNPYVNGAARQAIVFEYTDWTE 379 Query: 459 GNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLH 518 + N+ + + VGD+ FTC NE+AQ AE G +V+ Y +THR+ + W W GV+H Sbjct: 380 PDNPNSNRDALDKMVGDYHFTCNVNEFAQRYAEEGNNVYMYLYTHRSKGNPWPRWTGVMH 439 Query: 519 GDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNP-----AQDGEEWPNFSKE 573 GDEI Y FG+PLN +L Y E++ ++++ FAKTGNP + + EWP + Sbjct: 440 GDEINYVFGEPLNPTLGYTEDEKDFSRKIMRYWSNFAKTGNPNPNTASSEFPEWPKHTAH 499 Query: 574 DPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKV 608 Y + + RGP +C+FW YLP++ Sbjct: 500 GRHYLELGLNTSF--VGRGPRLRQCAFWKKYLPQL 532 >2W6C-X nrPDB Length = 586 Score = 404 bits (1037), Expect = e-113, Method: Compositional matrix adjust. Identities = 217/588 (36%), Positives = 322/588 (54%), Gaps = 63/588 (10%) Query: 42 RLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLS 101 L+V T SG V G V V + + GIP+A+PPV ++RFR+P P +PW GV +A+ Sbjct: 26 ELLVNTKSGKVMGTRVPVLSSHISAFLGIPFAEPPVGNMRFRRPEPKKPWSGVWNASTYP 85 Query: 102 ATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQA 161 C Q E FPGFSG E+WNPN +SEDCLY+N+W P+ Sbjct: 86 NNCQQYVDEQFPGFSGSEMWNPNREMSEDCLYLNIWVPSP-------------------- 125 Query: 162 DTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVG 221 P++TT +++WIYGGGF +GS+TLD+YN +A V++ S YRVG Sbjct: 126 ---------RPKSTT----VMVWIYGGGFYSGSSTLDVYNGKYLAYTEEVVLVSLSYRVG 172 Query: 222 AFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSS 281 AFGFL L ++EAPGNVGL DQ +A++W+ DN FGG+P+ +T+FGESAG +S Sbjct: 173 AFGFLALHG------SQEAPGNVGLLDQRMALQWVHDNIQFFGGDPKTVTIFGESAGGAS 226 Query: 282 VNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMT----SEKAVEIGKALINDCNCNASMLKT 337 V ++SP +R L +R ++QSG+ N PW+ ++ +AVE+G+ L +CN N+ Sbjct: 227 VGMHILSPGSRDLFRRAILQSGSPNCPWASVSVAEGRRRAVELGRNL--NCNLNSD---- 280 Query: 338 NPAHVMSCMRSVDAKTISVQQWN--SYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDY 395 ++ C+R + + +WN + I F P IDG F P +++ + + K Sbjct: 281 --EELIHCLREKKPQELIDVEWNVLPFDSIFRFSFVPVIDGEFFPTSLESMLNSGNFKKT 338 Query: 396 DILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYT 455 IL+G +DEG++FLLY F KD + + R+ ++ + A +A+ QYT Sbjct: 339 QILLGVNKDEGSFFLLYG-APGFSKDSESKISREDFMSGVKLSVPHANDLGLDAVTLQYT 397 Query: 456 SW-EGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWM 514 W + N G +N+ + VGDH CP + + G + Y+F HR S +W EWM Sbjct: 398 DWMDDNNGIKNRDGLDDIVGDHNVICPLMHFVNKYTKFGNGTYLYFFNHRASNLVWPEWM 457 Query: 515 GVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQ---DGEEWPNFS 571 GV+HG EIE+ FG PL L Y E L +R++ FAKTGNP + +WP F+ Sbjct: 458 GVIHGYEIEFVFGLPLVKELNYTAEEEALSRRIMHYWATFAKTGNPNEPHSQESKWPLFT 517 Query: 572 KEDPVYYIFSTDD-KIEKLARGPLAARCSFWNDYLPKVRSWAGTCDGD 618 ++ + +T+ K+ + R C FWN +LPK+ + A CDG+ Sbjct: 518 TKEQKFIDLNTEPMKVHQRLR---VQMCVFWNQFLPKLLN-ATACDGE 561 >6QAA-A nrPDB Length = 557 Score = 395 bits (1016), Expect = e-110, Method: Compositional matrix adjust. Identities = 222/588 (37%), Positives = 320/588 (54%), Gaps = 52/588 (8%) Query: 27 LVLSLHLSGVCGVIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPV 86 +L L G D +++ T +G VRG +TV G V + GIPYA+PP+ LRF+KP Sbjct: 16 FLLLCMLIGKSHTEDDIIIATKNGKVRGMQLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQ 75 Query: 87 PAEPWHGVLDATGLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRH 146 W + +AT + +C Q + FPGF G E+WNPNT++SEDCLY+NVW PA Sbjct: 76 SLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAP----- 130 Query: 147 GRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMA 206 P+N T +LIWIYGGGF TG+++L +Y+ +A Sbjct: 131 ------------------------KPKNAT----VLIWIYGGGFQTGTSSLHVYDGKFLA 162 Query: 207 AVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGN 266 V VIV S YRVGA GFL L P P EAPGN+GL+DQ LA++W++ N AFGGN Sbjct: 163 RVERVIVVSMNYRVGALGFLAL-PGNP-----EAPGNMGLFDQQLALQWVQKNIAAFGGN 216 Query: 267 PEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALIN 326 P+ +TLFGESAG++SV+ L+SP + L R ++QSG+ NAPW+ + +A L Sbjct: 217 PKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAK 276 Query: 327 DCNCNASMLKTNPAHVMSCMRSVDAKTISVQQ--WNSYSGILSFPSAPTIDGAFLPADPM 384 C+ + N ++ C+R+ D + I + + Y LS PT+DG FL P Sbjct: 277 LTGCS----RENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPD 332 Query: 385 TLMKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQ 444 L++ K IL+G +DEGT FL+Y F KD+ + + R ++ E + F ++ Sbjct: 333 ILLELGQFKKTQILVGVNKDEGTAFLVYG-APGFSKDNNSIITRKEFQEGLKIFFPGVSE 391 Query: 445 AEREAIIFQYTSWEGNPGYQN-QQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTH 503 +E+I+F YT W + +N ++ +G VGD+ F CP E+ + +E G + +YYF H Sbjct: 392 FGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEH 451 Query: 504 RTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQD 563 R+S W EWMGV+HG EIE+ FG PL QY E L + ++ FAK GNP + Sbjct: 452 RSSKLPWPEWMGVMHGYEIEFVFGLPLERRDQYTKAEEILSRSIVKRWANFAKYGNPQET 511 Query: 564 GEE---WPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKV 608 + WP F + Y +T+ ++ A +C FW + PKV Sbjct: 512 QNQSTSWPVFKSTEQKYLTLNTEST--RIMTKLRAQQCRFWTSFFPKV 557 >5HQ3-A nrPDB Length = 548 Score = 393 bits (1009), Expect = e-109, Method: Compositional matrix adjust. Identities = 224/582 (38%), Positives = 321/582 (55%), Gaps = 50/582 (8%) Query: 43 LVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLSA 102 L+V T G +RG +T G V + GIP+A+PPV RFR P P +PW GV DAT Sbjct: 9 LLVTTRGGRLRGIRLTTPGGPVSAFLGIPFAEPPVGPRRFRPPEPKQPWSGVWDATTFQN 68 Query: 103 TCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQAD 162 C Q +PGF G E+WNPN N+SEDCLY+NVW P +P K Sbjct: 69 VCYQYVDTLYPGFEGTEMWNPNRNLSEDCLYLNVWTP---------------YPRPK--- 110 Query: 163 TDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGA 222 N P+++WIYGGGF +GS++LD+Y+ + V++ S YRVGA Sbjct: 111 --------------NPAPVMVWIYGGGFYSGSSSLDVYDGRFLVRTERVVLVSMNYRVGA 156 Query: 223 FGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSV 282 FGFL L + EAPGNVGL DQ LA++W+++N AFGG+P +TLFGESAG++SV Sbjct: 157 FGFLALP------GSREAPGNVGLLDQRLALQWVQENIAAFGGDPTSVTLFGESAGAASV 210 Query: 283 NAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHV 342 L+SP +RGL R ++QSG NAPW++++ E+A L C N + Sbjct: 211 GMHLLSPPSRGLFHRAILQSGAPNAPWAYVSREEARRRALQLAKLVGCPPGGTGGNDTEL 270 Query: 343 MSCMRSVDAKTISVQQWN--SYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMG 400 ++C+R+ + + +W+ + F P +DG FLP P L+ D K D+L+G Sbjct: 271 VACLRNRPPQELVNHEWHVLPQESVFRFSFVPVVDGDFLPDTPEALINNGDFKGLDVLVG 330 Query: 401 NVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSW--E 458 +DEG+YFL+Y F KD+ + + R+++LE + + + EAI+ YT W Sbjct: 331 VNKDEGSYFLVYG-APGFSKDNESLISREEFLEGVRVGVPQVSDLAAEAIVLHYTDWLHP 389 Query: 459 GNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLH 518 +P +N+ + VGDH CP ++AQ A GA V+ Y F HR+ST W EWMGV H Sbjct: 390 EDPA-KNRDALSDVVGDHNVICPVAQFAQRYAANGARVYAYVFEHRSSTLPWPEWMGVPH 448 Query: 519 GDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQ----DGEEWPNFSKED 574 G EIE+ FG PL+ S Y E+ +R++ FA+TG+P + +WP ++ ++ Sbjct: 449 GYEIEFIFGIPLDPSRNYTKEEKIFARRLMRYWANFARTGDPNEPRDPKAPQWPPYTADE 508 Query: 575 PVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWAGTCD 616 Y S D + ++ RG A C+FWN +LPK+ S T D Sbjct: 509 QKY--VSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLD 548 >1Q83-A nrPDB Length = 580 Score = 392 bits (1006), Expect = e-109, Method: Compositional matrix adjust. Identities = 219/583 (37%), Positives = 312/583 (53%), Gaps = 50/583 (8%) Query: 42 RLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLS 101 +L+V+ G +RG + G V + GIP+A+PPV RF P P PW GVLDAT Sbjct: 38 QLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQ 97 Query: 102 ATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQA 161 C Q +PGF G E+WNPN +SEDCLY+NVW P Sbjct: 98 NVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYP-------------------- 137 Query: 162 DTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVG 221 P + T P+LIWIYGGGF +G+A+LD+Y+ +A V ++ S YRVG Sbjct: 138 ---------RPASPT---PVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSMNYRVG 185 Query: 222 AFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSS 281 FGFL L + EAPGNVGL DQ LA++W+++N AFGG+P +TLFGESAG++S Sbjct: 186 TFGFLALP------GSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAAS 239 Query: 282 VNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAH 341 V ++S +R L R ++QSGT N PW+ +++ +A L C N Sbjct: 240 VGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTE 299 Query: 342 VMSCMRSVDAKTISVQQWN--SYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILM 399 +++C+R+ A+ + +W+ I F P +DG FL P L+ T D +D +L+ Sbjct: 300 LIACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLV 359 Query: 400 GNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSW-- 457 G V+DEG+YFL+Y + F KD+ + + R ++L + +A+ EA++ YT W Sbjct: 360 GVVKDEGSYFLVYG-VPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLH 418 Query: 458 EGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVL 517 +P + + + VGDH CP + A LA +GA V+ Y F HR ST W WMGV Sbjct: 419 PEDPTHL-RDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVP 477 Query: 518 HGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNP----AQDGEEWPNFSKE 573 HG EIE+ FG PL+ SL Y ER +R++ FA+TG+P +WP ++ Sbjct: 478 HGYEIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPYTTA 537 Query: 574 DPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWAGTCD 616 Y S + K ++ RG A C+FWN +LPK+ S T D Sbjct: 538 AQQY--VSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSATDTLD 578 >2X8B-A nrPDB Length = 583 Score = 379 bits (973), Expect = e-105, Method: Compositional matrix adjust. Identities = 210/582 (36%), Positives = 308/582 (52%), Gaps = 50/582 (8%) Query: 43 LVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLSA 102 L+V G +RG + G V + GIP+A+PP+ RF P P +PW GV+DAT + Sbjct: 8 LLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQS 67 Query: 103 TCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQAD 162 C Q +PGF G E+WNPN +SEDCLY+NVW P +P Sbjct: 68 VCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTP---------------YPR----- 107 Query: 163 TDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGA 222 T+ P+L+WIYGGGF +G+++LD+Y+ + ++ S YRVGA Sbjct: 108 ------------PTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGA 155 Query: 223 FGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSV 282 FGFL L + EAPGNVGL DQ LA++W+++N AFGG+P +TLFGESAG++SV Sbjct: 156 FGFLALPG------SREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGESAGAASV 209 Query: 283 NAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHV 342 L+SP +RGL R ++QSG N PW+ + +A L + C N + Sbjct: 210 GMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTGGNDTEL 269 Query: 343 MSCMRSVDAKTISVQQWN--SYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMG 400 ++C+R+ A+ + +W+ + F P +DG FL P L+ D +L+G Sbjct: 270 VACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHGLQVLVG 329 Query: 401 NVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSW--E 458 V+DEG+YFL+Y F KD+ + + R ++L + + + EA++ YT W Sbjct: 330 VVKDEGSYFLVYG-APGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDWLHP 388 Query: 459 GNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLH 518 +P + ++ + VGDH CP + A LA +GA V+ Y F HR ST W WMGV H Sbjct: 389 EDPA-RLREALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWMGVPH 447 Query: 519 GDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQ----DGEEWPNFSKED 574 G EIE+ FG PL+ S Y E+ +R++ FA+TG+P + +WP ++ Sbjct: 448 GYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWPPYTAGA 507 Query: 575 PVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWAGTCD 616 Y S D + ++ RG A C+FWN +LPK+ S T D Sbjct: 508 QQY--VSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLD 547 >2WQZ-A nrPDB Length = 588 Score = 235 bits (599), Expect = 5e-62, Method: Compositional matrix adjust. Identities = 170/606 (28%), Positives = 279/606 (46%), Gaps = 92/606 (15%) Query: 44 VVQTSSGPVRGRSVTVQGR---EVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGL 100 VV T+ G +RG + V Y G+PYA PP + RF+ P P W G+ + T Sbjct: 16 VVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQF 75 Query: 101 SATCVQERYEYFPGFSGEEIW---NPNT------NVSEDCLYINVWAPAKARLRHGRGAN 151 +A C Q E IW N +T + +EDCLY+N++ P Sbjct: 76 AAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVP------------ 123 Query: 152 GGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNV 211 T+ IH+ N + P++++I+GG +M G+ ++ + I+A+ GNV Sbjct: 124 -----------TEDDIHDQNSKK-----PVMVYIHGGSYMEGTG--NMIDGSILASYGNV 165 Query: 212 IVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMT 271 IV + YR+G GFL S + A GN GL DQ A+RW+++N AFGG+P+ +T Sbjct: 166 IVITINYRLGILGFL-------STGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVT 218 Query: 272 LFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCN 331 +FG AG+S V+ +S + GL ++ ++QSGT + W+ + + + + L + CN Sbjct: 219 IFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWA--VNYQPAKYTRILADKVGCN 276 Query: 332 ASMLKTNPAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTAD 391 ML T ++ C+R+ + K + Q + ++F P IDG +P DP LM+ + Sbjct: 277 --MLDT--TDMVECLRNKNYKELIQQTITPATYHIAF--GPVIDGDVIPDDPQILMEQGE 330 Query: 392 LKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMN---NIFG--KATQAE 446 +YDI++G + EG F+D ++ P D + N N++G + Sbjct: 331 FLNYDIMLGVNQGEGL-----KFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTL 385 Query: 447 REAIIFQYTSWEGNPGYQNQQQIGRAV-GDHFFTCPTNEYAQALAERGASVHYYYFTHRT 505 RE I F YT W + +++ A+ DH + P A A+ G+ ++Y F H Sbjct: 386 RETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHC 445 Query: 506 STSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVI-----EFAKTGNP 560 + + W HGDE+ Y FG P+ + MLSAV+ FAKTG+P Sbjct: 446 QSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDP 505 Query: 561 AQ----------------DGEEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDY 604 Q + W ++ +D +Y ++ R A + +FW + Sbjct: 506 NQPVPQDTKFIHTKPNRFEEVAWSRYNPKDQLYLHIGLKPRVRDHYR---ATKVAFWLEL 562 Query: 605 LPKVRS 610 +P + + Sbjct: 563 VPHLHN 568 >6H18-A nrPDB Length = 547 Score = 231 bits (588), Expect = 9e-61, Method: Compositional matrix adjust. Identities = 164/533 (30%), Positives = 242/533 (45%), Gaps = 78/533 (14%) Query: 45 VQTSSGPVRG--RSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLSA 102 V T G V G + + + G V ++ GIP+A P P P W G L A Sbjct: 20 VYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKA---LENPQPHPGWQGTLKAKNFKK 76 Query: 103 TCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQAD 162 C+Q I +T EDCLY+N+W P GR KQ Sbjct: 77 RCLQA-----------TITQDSTYGDEDCLYLNIWVP------QGR----------KQVS 109 Query: 163 TDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSA------TLDIYNADIMAAVGNVIVASF 216 D LP++IWIYGG F+ GS +Y+ + +A GNVIV +F Sbjct: 110 RD--------------LPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTF 155 Query: 217 QYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGES 276 YRVG GFL S PGN GL DQ +AI W+K N AFGG+P+ +TLFGES Sbjct: 156 NYRVGPLGFL-------STGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPDNITLFGES 208 Query: 277 AGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLK 336 AG +SV+ Q +SP +GL++R + QSG +PW + + + K + C Sbjct: 209 AGGASVSLQTLSPYNKGLIRRAISQSGVALSPW--VIQKNPLFWAKKVAEKVGCPVG--- 263 Query: 337 TNPAHVMSCMRSVDAKTISVQQWNSYSGILSFPS------APTIDGAFLPADPMTLMKTA 390 + A + C++ D + +++ +G L +P P IDG F+P DP+ L A Sbjct: 264 -DAARMAQCLKVTDPRALTLAYKVPLAG-LEYPMLHYVGFVPVIDGDFIPDDPINLY--A 319 Query: 391 DLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAI 450 + D D + G +G F D + +K + D Y + K + + Sbjct: 320 NAADIDYIAGTNNMDGHIFASID-MPAINKGNKKVTEEDFYKLVSEFTITKGLRGAKTTF 378 Query: 451 IFQYTSWEGNPGYQNQQQ-IGRAVGDHFFTCPTN-EYAQALAE-RGASVHYYYFTHRTST 507 SW +P +N+++ + D F PT AQ A + A + Y F+H + Sbjct: 379 DVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIALAQHRANAKSAKTYAYLFSHPSRM 438 Query: 508 SLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNP 560 ++ +W+G H D+I+Y FG+P YRP +R + K M++ FAKTG+P Sbjct: 439 PVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAKTGDP 491 >3BIX-A nrPDB Length = 574 Score = 218 bits (556), Expect = 6e-57, Method: Compositional matrix adjust. Identities = 163/602 (27%), Positives = 265/602 (44%), Gaps = 91/602 (15%) Query: 44 VVQTSSGPVRGRSVTVQGR---EVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGL 100 +V T+ G +RG + V + G+PYA PP + RF+ P P PW + +AT Sbjct: 12 LVTTNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGEHRFQPPEPPSPWSDIRNATQF 71 Query: 101 SATCVQERYEYFPGFSGEEIWNPNT---------NVSEDCLYINVWAPAKARLRHGRGAN 151 + C Q + +W N + SEDCLY+N++ P + +R Sbjct: 72 APVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDDIRD----- 126 Query: 152 GGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNV 211 +G P+ P++++I+GG +M G+ L Y+ ++A+ GNV Sbjct: 127 -----------------SGGPK------PVMVYIHGGSYMEGTGNL--YDGSVLASYGNV 161 Query: 212 IVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMT 271 IV + YR+G GFL S + A GN GL D A+RW +N FGG+P +T Sbjct: 162 IVITVNYRLGVLGFL-------STGDQAAKGNYGLLDLIQALRWTSENIGFFGGDPLRIT 214 Query: 272 LFGESAGSSSVNAQLMSPVT-RGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNC 330 +FG AG S VN +S + +GL +R + QSGT + W+ S + + + L C Sbjct: 215 VFGSGAGGSCVNLLTLSHYSEKGLFQRAIAQSGTALSSWA--VSFQPAKYARILATKVGC 272 Query: 331 NASMLKTNPAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTA 390 N S + ++ C++ K + Q ++F P IDG +P DP LM+ Sbjct: 273 NVS----DTVELVECLQKKPYKELVDQDVQPARYHIAF--GPVIDGDVIPDDPQILMEQG 326 Query: 391 DLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYL--EIMNNIFG--KATQAE 446 + +YDI++G + EG F+ + D DD + + ++N++G + Sbjct: 327 EFLNYDIMLGVNQGEGLKFVE----NIVDSDDGVSASDFDFAVSNFVDNLYGYPEGKDVL 382 Query: 447 REAIIFQYTSWEGNPGYQNQQQIGRAV-GDHFFTCPTNEYAQALAERGASVHYYYFTHRT 505 RE I F YT W + +++ A+ DH + P A + G+ ++Y F H Sbjct: 383 RETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAFYHHC 442 Query: 506 STSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVI-----EFAKTGNP 560 T W HGDE+ Y G P+ + P MLSAV+ FAKTG+P Sbjct: 443 QTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDP 502 Query: 561 AQ----------------DGEEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDY 604 Q + W +S++D +Y ++++ R A + + W + Sbjct: 503 NQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYR---ANKVNLWLEL 559 Query: 605 LP 606 +P Sbjct: 560 VP 561 >1AKN-A nrPDB Length = 579 Score = 215 bits (547), Expect = 5e-56, Method: Compositional matrix adjust. Identities = 150/532 (28%), Positives = 239/532 (44%), Gaps = 76/532 (14%) Query: 45 VQTSSGPVRG--RSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLSA 102 V T G V G + +++ G + ++ GIP+A P KP W G L A Sbjct: 6 VYTEGGFVEGVNKKLSLFGDSIDIFKGIPFAAAPKA---LEKPERHPGWQGTLKAKSFKK 62 Query: 103 TCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQAD 162 C+Q + +T +EDCLY+N+W P GR Sbjct: 63 RCLQAT-----------LTQDSTYGNEDCLYLNIWVP------QGR-------------- 91 Query: 163 TDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSA------TLDIYNADIMAAVGNVIVASF 216 + ++ LP++IWIYGG F+ G++ + +Y+ + +A GNVIV +F Sbjct: 92 ----------KEVSHDLPVMIWIYGGAFLMGASQGANFLSNYLYDGEEIATRGNVIVVTF 141 Query: 217 QYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGES 276 YRVG GFL S PGN GLWDQ +AI W+K N AFGG+P+ +TLFGES Sbjct: 142 NYRVGPLGFL-------STGDSNLPGNYGLWDQHMAIAWVKRNIEAFGGDPDNITLFGES 194 Query: 277 AGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLK 336 AG +SV+ Q +SP +GL+KR + QSG PW+ + + K + C Sbjct: 195 AGGASVSLQTLSPYNKGLIKRAISQSGVGLCPWA--IQQDPLFWAKRIAEKVGCPVD--- 249 Query: 337 TNPAHVMSCMRSVDAKTISVQQW-----NSYSGILSFPSAPTIDGAFLPADPMTLMKTAD 391 + + + C++ D + +++ Y + P IDG F+P DP+ L A+ Sbjct: 250 -DTSKMAGCLKITDPRALTLAYKLPLGSTEYPKLHYLSFVPVIDGDFIPDDPVNLY--AN 306 Query: 392 LKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAII 451 D D + G +G F+ D + + + D Y + K + Sbjct: 307 AADVDYIAGTNDMDGHLFVGMD-VPAINSNKQDVTEEDFYKLVSGLTVTKGLRGANATYE 365 Query: 452 FQYTSWEGNPGYQNQQQIGRAV-GDHFFTCPTN-EYAQALAE-RGASVHYYYFTHRTSTS 508 W + + +++ + D F PT AQ + + A+ + Y F+ + Sbjct: 366 VYTEPWAQDSSQETRKKTMVDLETDILFLIPTKIAVAQHKSHAKSANTYTYLFSQPSRMP 425 Query: 509 LWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNP 560 ++ +WMG H D+++Y FG+P L YR +R + K M++ FA+TG+P Sbjct: 426 IYPKWMGADHADDLQYVFGKPFATPLGYRAQDRTVSKAMIAYWTNFARTGDP 477 >5V5V-A nrPDB Length = 582 Score = 211 bits (537), Expect = 7e-55, Method: Compositional matrix adjust. Identities = 165/608 (27%), Positives = 272/608 (44%), Gaps = 81/608 (13%) Query: 44 VVQTSSGPVRGRSVTVQGR---EVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGL 100 VV T+ G VRG + V + G+PYA PP+ RF+ P W GV +AT L Sbjct: 3 VVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTL 62 Query: 101 SATCVQERYEYFPGFSGEEIWNPN--------TNVSEDCLYINVWAPAKARLRHGRGANG 152 C Q + P + N N SEDCLY+N++ P + Sbjct: 63 PPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTE----------- 111 Query: 153 GEHPNGKQADTDHLIHNGNPQNT----TNGLPILIWIYGGGFMTGSATLDIYNADIMAAV 208 + P K+ D L NP +T + P++++++GG +M G+ ++++ ++AA Sbjct: 112 -DGPLTKKRDEATL----NPPDTDIRDSGKKPVMLFLHGGSYMEGTG--NMFDGSVLAAY 164 Query: 209 GNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPE 268 GNVIVA+ YR+G GFL S + A GN GL DQ A+RWL +N FGG+PE Sbjct: 165 GNVIVATLNYRLGVLGFL-------STGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPE 217 Query: 269 WMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDC 328 +T+FG AG+S VN ++S + GL ++ + QSGT + WS + + ++ + L Sbjct: 218 RITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWS--VNYQPLKYTRLLAAKV 275 Query: 329 NCNASMLKTNPAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMK 388 C+ + + + C+R ++ + Q ++F D + LM+ Sbjct: 276 GCD----REDSTEAVECLRRKSSRELVDQDVQPARYHIAFGPVVDGDVVPDDPE--ILMQ 329 Query: 389 TADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYL--EIMNNIFG--KATQ 444 + +YD+L+G + EG F+ D + +D + + ++N++G + Sbjct: 330 QGEFLNYDMLIGVNQGEGLKFVE----DSAESEDGVSASAFDFTVSNFVDNLYGYPEGKD 385 Query: 445 AEREAIIFQYTSW-EGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTH 503 RE I F YT W + + G ++ + DH + P A+ A+ + V++Y F H Sbjct: 386 VLRETIKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYH 445 Query: 504 RTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVI-----EFAKTG 558 EW HGDE+ Y FG P+ + P MLSAV+ FAKTG Sbjct: 446 HCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTG 505 Query: 559 NPAQDGEE----------------WPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWN 602 +P Q + W F+ ++ Y ++ R A + +FW Sbjct: 506 DPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYR---ANKVAFWL 562 Query: 603 DYLPKVRS 610 + +P + + Sbjct: 563 ELVPHLHN 570 >1C7J-A nrPDB Length = 489 Score = 206 bits (525), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 166/550 (30%), Positives = 240/550 (43%), Gaps = 88/550 (16%) Query: 44 VVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLSAT 103 +V T G V+G T G VH + GIPYAKPPV RF+ P P E W VLDAT Sbjct: 5 IVTTQYGKVKG--TTENG--VHKWKGIPYAKPPVGQWRFKAPEPPEVWEDVLDATAYGPV 60 Query: 104 CVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADT 163 C Q P + SEDCLY+NV+AP Sbjct: 61 CPQ------PSDLLSLSYTELPRQSEDCLYVNVFAP------------------------ 90 Query: 164 DHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAF 223 + LP+++WI+GG F G+ + +Y+ +AA G VIV + YR+G F Sbjct: 91 ---------DTPSQNLPVMVWIHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPF 141 Query: 224 GFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVN 283 GF+HL S F E N+GL DQA A++W+++N AFGG+P+ +T+FGESAG S+ Sbjct: 142 GFMHL-----SSFDEAYSDNLGLLDQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIA 196 Query: 284 AQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASML-KTNPAHV 342 A L P +GL ++ +M+SG MT E+A A + N S L + + Sbjct: 197 ALLAMPAAKGLFQKAIMESGASRT----MTKEQAASTAAAFLQVLGINESQLDRLHTVAA 252 Query: 343 MSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNV 402 +++ D I+ ++ I P +D LP +P + +L+G Sbjct: 253 EDLLKAADQLRIAEKE-----NIFQLFFQPALDPKTLPEEPEKSIAEGAASGIPLLIGTT 307 Query: 403 RDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPG 462 RDEG F D D + D LE GK AE+ A ++ + Sbjct: 308 RDEGYLFFTS------DSDVRSQETLDAALEYS---LGKPL-AEKAADLYPRSL------ 351 Query: 463 YQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLHGDEI 522 + QI V D F P +A A + A V Y F + + H E+ Sbjct: 352 ---ESQI-HMVTDLLFWRPAVAFASAQSHY-APVWMYRFDWHPEKPPYNK---AFHALEL 403 Query: 523 EYFFGQPLNNSLQYRPVE-----RELGKRMLSAVIEFAKTGNPAQDGEEWPNFSKEDPVY 577 + FG L+ + E ++L + SA I FAKTGNP+ + WP + +E Sbjct: 404 PFVFGN-LDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAVNWPAYHEETRET 462 Query: 578 YIFSTDDKIE 587 I ++ IE Sbjct: 463 VILDSEITIE 472 >1K4Y-A nrPDB Length = 534 Score = 185 bits (470), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 163/585 (27%), Positives = 252/585 (43%), Gaps = 86/585 (14%) Query: 44 VVQTSSGPVRGRSVTVQG--REVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLS 101 VV T G V G+ V+++G + V V+ G+P+AKPP+ LRF P PAE W V + T Sbjct: 3 VVDTVHGKVLGKFVSLEGFAQPVAVFLGVPFAKPPLGSLRFAPPQPAESWSHVKNTTSYP 62 Query: 102 ATCVQERYEYFPGFSGEEIW-NPNTNV----SEDCLYINVWAPAKARLRHGRGANGGEHP 156 C Q+ G E++ N N+ SEDCLY+N++ PA R GR Sbjct: 63 PMCSQDAVS---GHMLSELFTNRKENIPLKFSEDCLYLNIYTPADLTKR-GR-------- 110 Query: 157 NGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASF 216 LP+++WI+GGG M G A+ Y+ ++A NV+V + Sbjct: 111 ----------------------LPVMVWIHGGGLMVGGAS--TYDGLALSAHENVVVVTI 146 Query: 217 QYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGES 276 QYR+G +GF S E + GN G DQ A+RW++DN FGG+P +T+FGES Sbjct: 147 QYRLGIWGFF-------STGDEHSRGNWGHLDQVAALRWVQDNIANFGGDPGSVTIFGES 199 Query: 277 AGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLK 336 AG SV+ L+SP+T+ L R + +SG A S + + + + + + C Sbjct: 200 AGGQSVSILLLSPLTKNLFHRAISESGV--ALLSSLFRKNTKSLAEKIAIEAGCKT---- 253 Query: 337 TNPAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAP---------TIDGAFLPADPMTLM 387 T A ++ C+R + + L P IDG LP P ++ Sbjct: 254 TTSAVMVHCLRQKTEEELMEVTLKMKFMALDLVGDPKENTAFLTTVIDGVLLPKAPAEIL 313 Query: 388 KTADLKDYDILMGNVRDEGTYFLLYDFIDY------FDKDDATALPRDKYLEIMNNIFGK 441 ++G + E + + + Y D+ AT L Y + N+ + Sbjct: 314 AEKKYNMLPYMVGINQQEFGWIIPMQMLGYPLSEGKLDQKTATELLWKSYPIV--NVSKE 371 Query: 442 ATQAEREAIIFQYTSWEGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYF 501 T E +Y +P + + + D F P+ A+ + GA + Y + Sbjct: 372 LTPVATE----KYLGGTDDP-VKKKDLFLDMLADLLFGVPSVNVARHHRDAGAPTYMYEY 426 Query: 502 THRTSTSLWGEWMGVL--HGDEIEYFFGQPLNNSLQYRPVERE--LGKRMLSAVIEFAKT 557 +R S S V+ HGDEI G P L+ E E L K ++ FA+ Sbjct: 427 RYRPSFSSDMRPKTVIGDHGDEIFSVLGAPF---LKEGATEEEIKLSKMVMKYWANFARN 483 Query: 558 GNPAQDG-EEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFW 601 GNP +G +WP + ++ I +T +KL +A W Sbjct: 484 GNPNGEGLPQWPAYDYKEGYLQIGATTQAAQKLKDKEVAFWTELW 528 >5FV4-A nrPDB Length = 544 Score = 185 bits (470), Expect = 5e-47, Method: Compositional matrix adjust. Identities = 168/594 (28%), Positives = 257/594 (43%), Gaps = 97/594 (16%) Query: 44 VVQTSSGPVRGRSVTVQG--REVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLS 101 VV T+ G V G+ V+++G + V V+ G+P+AKPP+ LRF P PAEPW V + T Sbjct: 8 VVDTAQGRVLGKYVSLEGLAQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYP 67 Query: 102 ATCVQERYEYFPGFSGEEIWNPNTN--------VSEDCLYINVWAPAKARLRHGRGANGG 153 C Q+ +G+ + TN SEDCLY+N++ PA R GR Sbjct: 68 PMCCQDP------VAGQMTSDLFTNRKERLIPEFSEDCLYLNIYTPADLTKR-GR----- 115 Query: 154 EHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIV 213 LP+++WI+GGG + G A+ Y+ +AA NV+V Sbjct: 116 -------------------------LPVMVWIHGGGLVVGGAS--TYDGLALAAHENVVV 148 Query: 214 ASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLF 273 + QYR+G +GF S E + GN G DQ A+ W+++N FGG+P +T+F Sbjct: 149 VAIQYRLGIWGFF-------STGDEHSRGNWGHLDQVAALHWVQENIANFGGDPGSVTIF 201 Query: 274 GESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNAS 333 GESAG SV+ ++SP+ + L R + +SG KA A++ C S Sbjct: 202 GESAGGESVSVLVLSPLAKNLFHRAISESGVAFTAGLVRKDMKAAAKQIAVLAGCKTTTS 261 Query: 334 MLKTNPAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAP---------TIDGAFLPADPM 384 A + C+R + L P +DG LP P Sbjct: 262 ------AVFVHCLRQKSEDELLDLTLKMKFFALDLHGDPRESHPFLTTVVDGVLLPKMPE 315 Query: 385 TLMKTADLKDYDILMGNVRDEGTYFLLYDFIDY------FDKDDATALPRDKYLEIMNNI 438 ++ D ++G + E + LL + + D+ AT+L Y + NI Sbjct: 316 EILAEKDFNTVPYIVGINKQEFGW-LLPTMMGFPLSEGKLDQKTATSLLWKSY--PIANI 372 Query: 439 FGKATQAEREAIIFQYTSWEGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHY 498 + T + +Y +P + + +GD F P+ A+ + GA + Sbjct: 373 PEELTPVATD----KYLGGTDDP-VKKKDLFLDLMGDVVFGVPSVTVARQHRDAGAPTYM 427 Query: 499 YYFTHRTSTSLWGEWMGVL--HGDEIEYFFGQPLNNSLQYRPVERE--LGKRMLSAVIEF 554 Y F +R S S + V+ HGDEI FG P L+ E E L K ++ F Sbjct: 428 YEFQYRPSFSSDKKPKTVIGDHGDEIFSVFGAPF---LRGDAPEEEVSLSKTVMKFWANF 484 Query: 555 AKTGNPAQDG-EEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPK 607 A++GNP +G WP + +E+ Y + + K +G +FWND L K Sbjct: 485 ARSGNPNGEGLPHWPMYDQEEG-YLQIGVNTQAAKRLKG---EEVAFWNDLLSK 534 >1MX5-A nrPDB Length = 548 Score = 181 bits (459), Expect = 9e-46, Method: Compositional matrix adjust. Identities = 164/590 (27%), Positives = 254/590 (43%), Gaps = 88/590 (14%) Query: 44 VVQTSSGPVRGRSVTVQG--REVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLS 101 VV T G V G+ V+++G + V ++ GIP+AKPP+ LRF P PAEPW V +AT Sbjct: 7 VVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYP 66 Query: 102 ATCVQERY--EYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGK 159 C Q+ + N +SEDCLY+N++ PA + Sbjct: 67 PMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLNIYTPADLTKK-------------- 112 Query: 160 QADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYR 219 N LP+++WI+GGG M G+A+ Y+ +AA NV+V + QYR Sbjct: 113 -----------------NRLPVMVWIHGGGLMVGAAS--TYDGLALAAHENVVVVTIQYR 153 Query: 220 VGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGS 279 +G +GF S E + GN G DQ A+RW++DN +FGGNP +T+FGESAG Sbjct: 154 LGIWGFF-------STGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGG 206 Query: 280 SSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNP 339 SV+ ++SP+ + L R + +SG A S + + V K L A T Sbjct: 207 ESVSVLVLSPLAKNLFHRAISESGV--ALTSVLVKKGDV---KPLAEQIAITAGCKTTTS 261 Query: 340 AHVMSCMRSVDAKTISVQQWNSYSGILSFPSAP---------TIDGAFLPADPMTLMKTA 390 A ++ C+R + + L P IDG L P L Sbjct: 262 AVMVHCLRQKTEEELLETTLKMKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAER 321 Query: 391 DLKDYDILMGNVRDEGTYFLLYDFIDY------FDKDDATALPRDKY--LEIMNNIFGKA 442 + ++G + E + L+ + Y D+ A +L Y + I + +A Sbjct: 322 NFHTVPYMVGINKQEFGW-LIPMLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEA 380 Query: 443 TQAEREAIIFQYTSWEGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFT 502 T+ +Y + + + + D F P+ A+ + GA + Y F Sbjct: 381 TE--------KYLGGTDD-TVKKKDLFLDLIADVMFGVPSVIVARNHRDAGAPTYMYEFQ 431 Query: 503 HRTSTSLWGEWMGVL--HGDEIEYFFGQPLNNSLQYRPVERE--LGKRMLSAVIEFAKTG 558 +R S S + V+ HGDE+ FG P L+ E E L K ++ FA+ G Sbjct: 432 YRPSFSSDMKPKTVIGDHGDELFSVFGAPF---LKEGASEEEIRLSKMVMKFWANFARNG 488 Query: 559 NPAQDG-EEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPK 607 NP +G WP +++++ I + +KL +A FW + K Sbjct: 489 NPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLKDKEVA----FWTNLFAK 534 >5THM-A nrPDB Length = 533 Score = 140 bits (354), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 137/547 (25%), Positives = 236/547 (43%), Gaps = 94/547 (17%) Query: 41 DRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVP-AEPWHGVLDATG 99 D L+VQ G +RGR + Y IPYA+PP DLRF P P + W + DAT Sbjct: 15 DPLLVQLPQGVLRGRD----NGSYYSYESIPYAEPPTGDLRFEAPEPYKQKWSDIFDATK 70 Query: 100 LSATCVQERYEYFPGFSGEEIWNPNTNV-SEDCLYINVWAPAKARLRHGRGANGGEHPNG 158 C+Q ++ PG N V EDCL ++V+ P ++ Sbjct: 71 TPVACLQWD-QFTPG--------ANKLVGEEDCLTVSVYKPKNSK--------------- 106 Query: 159 KQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQY 218 N P++ I+GG FM G+A + + ++M G I+ Y Sbjct: 107 -----------------RNSFPVVAHIHGGAFMFGAAWQNGHE-NVMRE-GKFILVKISY 147 Query: 219 RVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAG 278 R+G GFL S + PGN GL DQ LA++W+K N +FGG P+ + L G SAG Sbjct: 148 RLGPLGFL-------STGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGHSAG 200 Query: 279 SSSVNAQLMSPVTRGLVKRGMMQSGTMNAPW--SHMTSEKAVEIGKALINDCNCNASMLK 336 +SV+ Q++ L K SG PW E+A E+G+++ C ++ Sbjct: 201 GASVHLQMLREDFGQLAKAAFSFSGNALDPWVIQKGARERAFELGRSV----GCESA--- 253 Query: 337 TNPAHVMSCMRSVDAKTI--SVQQWNSYSGILSFPSAPTID-----GAFLPADPMTLMKT 389 + A + C++S A + +V+++ +S + P +P ++ GAF+ DP ++K+ Sbjct: 254 EDSASLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSDAPGAFITQDPRDVIKS 313 Query: 390 ADLKDYDILMGNVRDEGTY---FLLYDFIDYFDKDDATALPRDKYLEIMNN-IFGKATQA 445 + V ++G Y LL + DD +++LE+ +F + T+ Sbjct: 314 GKFGQVPWAVSYVTEDGGYNAALLLKERKSGVVIDDLN----ERWLELAPYLLFYRDTKT 369 Query: 446 EREAIIFQYT---SWEGNPGYQ--NQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYY 500 +++ + + GN + + ++ R D F T E + G S Y Y Sbjct: 370 KKDMDDYSRKIKQEYIGNQRFDIGSYSELQRLFTDILFKNGTQESLDLHRKYGKSPVYAY 429 Query: 501 FTHRTSTSLWGEWM--------GVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVI 552 + + + G +HGD+ F + + ++ RP E+ + + ++ + Sbjct: 430 VYDNPAEKGIAQVLANRTDYDFGTVHGDDYSLIFENSVRD-VEMRPDEQIISRNFINMLA 488 Query: 553 EFAKTGN 559 +FA + + Sbjct: 489 DFASSDD 495 >1GZ7-A nrPDB Length = 534 Score = 135 bits (340), Expect = 6e-32, Method: Compositional matrix adjust. Identities = 149/552 (26%), Positives = 230/552 (41%), Gaps = 124/552 (22%) Query: 67 YTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLSATCVQERYEYFPGFSGEEIWNPNT- 125 + GIP+A+PPV LRF+ PVP T +C+Q P S E+ N Sbjct: 23 FLGIPFAEPPVGTLRFKPPVPYSASLNGQQFTSYGPSCMQMN----PMGSFEDTLPKNAL 78 Query: 126 -------------NVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNP 172 EDCL INV P R Sbjct: 79 DLVLQSKIFQVVLPNDEDCLTINVIRPPGTR----------------------------- 109 Query: 173 QNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAA----VGN-VIVASFQYRVGAFGFLH 227 + GLP+++WI+GGGF G ++L + D M A +G VI S YRV ++GFL Sbjct: 110 --ASAGLPVMLWIFGGGFELGGSSL--FPGDQMVAKSVLMGKPVIHVSMNYRVASWGFLA 165 Query: 228 LAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLM 287 P++ E GN GL DQ LA++W+ DN FGG+P +T++GESAGS S L+ Sbjct: 166 -GPDI----QNEGSGNAGLHDQRLAMQWVADNIAGFGGDPSKVTIYGESAGSMSTFVHLV 220 Query: 288 ------SPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAH 341 + + L + +MQSG M P + EI ++ C ++ K Sbjct: 221 WNDGDNTYNGKPLFRAAIMQSGCM-VPSDPVDGTYGTEIYNQVVASAGCGSASDK----- 274 Query: 342 VMSCMRSVDAKTISVQQWNSYSGILSFPS-----APTIDGAFLPADPMTLMKTADLKDYD 396 ++C+R + T+ Q + G+L++PS P DG F+ D L++ Sbjct: 275 -LACLRGLSQDTL-YQATSDTPGVLAYPSLRLSYLPRPDGTFITDDMYALVRDGKYAHVP 332 Query: 397 ILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTS 456 +++G+ DEGT F L ++ A A + ++ A+ AE + ++ YTS Sbjct: 333 VIIGDQNDEGTLFGLSS-LNVTTDAQARAYFKQSFIH--------ASDAEIDTLMAAYTS 383 Query: 457 --WEGNP---GYQNQ-----QQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTS 506 +G+P G N ++I +GD FT Y + G Y F + Sbjct: 384 DITQGSPFDTGIFNAITPQFKRISALLGDLAFTL-ARRYFLNYYQGGTK---YSFLSKQL 439 Query: 507 TSLWGEWMGVLHGDEI---EYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQD 563 + L +G HG++I +Y G + S+ Y +A I FA +P + Sbjct: 440 SGL--PVLGTFHGNDIIWQDYLVG---SGSVIYN-----------NAFIAFANDLDPNKA 483 Query: 564 G--EEWPNFSKE 573 G WP ++ Sbjct: 484 GLWTNWPTYTSS 495 >3RAR-A nrPDB Length = 534 Score = 135 bits (339), Expect = 8e-32, Method: Compositional matrix adjust. Identities = 151/557 (27%), Positives = 233/557 (41%), Gaps = 130/557 (23%) Query: 65 HVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDA---TGLSATCVQER-----YEYFPGFS 116 + GIP+A+PPV +LRF+ PVP + G LD T +C+Q+ E P + Sbjct: 21 EAFLGIPFAEPPVGNLRFKDPVP---YSGSLDGQKFTSYGPSCMQQNPEGTYEENLPKAA 77 Query: 117 GE-----EIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGN 171 + +++ + SEDCL INV P + GAN Sbjct: 78 LDLVMQSKVFEAVSPSSEDCLTINVVRPPGTK----AGAN-------------------- 113 Query: 172 PQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMA---AVGNVIV-ASFQYRVGAFGFLH 227 LP+++WI+GGGF G T A ++ A+G I+ S YRV ++GFL Sbjct: 114 -------LPVMLWIFGGGFEVG-GTSTFPPAQMITKSIAMGKPIIHVSVNYRVSSWGFL- 164 Query: 228 LAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLM 287 E E N GL DQ L ++W+ DN AFGG+P +T+FGESAGS SV ++ Sbjct: 165 ----AGDEIKAEGSANAGLKDQRLGMQWVADNIAAFGGDPTKVTIFGESAGSMSVMCHIL 220 Query: 288 ------SPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAH 341 + + L + G+MQSG M P + EI L ++ C ++ K Sbjct: 221 WNDGDNTYKGKPLFRAGIMQSGAM-VPSDAVDGIYGNEIFDLLASNAGCGSASDK----- 274 Query: 342 VMSCMRSVDAKTISVQQWNSYSGILSFPS-----APTIDGAFLPADPMTLMKTADLKDYD 396 ++C+R V + T+ N+ G L++ S P DG + D L++ + Sbjct: 275 -LACLRGVSSDTLE-DATNNTPGFLAYSSLRLSYLPRPDGVNITDDMYALVREGKYANIP 332 Query: 397 ILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTS 456 +++G+ DEGT +F + E F A+ AE + ++ Y Sbjct: 333 VIIGDQNDEGT---------FFGTSSLNVTTDAQAREYFKQSFVHASDAEIDTLMTAYPG 383 Query: 457 --WEGNP---GYQNQ-----QQIGRAVGDHFFTCPTNEYAQALAERGASVHY-----YYF 501 +G+P G N ++I +GD FT LA R HY Y F Sbjct: 384 DITQGSPFDTGILNALTPQFKRISAVLGDLGFT---------LARRYFLNHYTGGTKYSF 434 Query: 502 THRTSTSLWGEWMGVLHGDEI---EYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTG 558 + + L +G H ++I +Y G + SL Y +A I FA Sbjct: 435 LSKQLSGL--PVLGTFHSNDIVFQDYLLG---SGSLIYN-----------NAFIAFATDL 478 Query: 559 NPAQDG--EEWPNFSKE 573 +P G +WP ++ Sbjct: 479 DPNTAGLLVKWPEYTSS 495 >1LLF-A nrPDB Length = 534 Score = 130 bits (328), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 109/374 (29%), Positives = 169/374 (45%), Gaps = 74/374 (19%) Query: 65 HVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDA---TGLSATCVQER----YEYFPGFSG 117 + GIP+A+PPV +LRF+ PVP + G L+ T +C+Q+ +E G + Sbjct: 21 EAFLGIPFAEPPVGNLRFKDPVP---YSGSLNGQKFTSYGPSCMQQNPEGTFEENLGKTA 77 Query: 118 ------EEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGN 171 +++ SEDCL INV P + GAN Sbjct: 78 LDLVMQSKVFQAVLPQSEDCLTINVVRPPGTK----AGAN-------------------- 113 Query: 172 PQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAV---GNVIVASFQYRVGAFGFLHL 228 LP+++WI+GGGF GS T+ + +V +I + YRV ++GFL Sbjct: 114 -------LPVMLWIFGGGFEIGSPTIFPPAQMVTKSVLMGKPIIHVAVNYRVASWGFL-- 164 Query: 229 APEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLM- 287 + E GN GL DQ L ++W+ DN FGG+P +T+FGESAGS SV L+ Sbjct: 165 ---AGDDIKAEGSGNAGLKDQRLGMQWVADNIAGFGGDPSKVTIFGESAGSMSVLCHLIW 221 Query: 288 -----SPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHV 342 + + L + G+MQSG M P + EI ++ C ++ K Sbjct: 222 NDGDNTYKGKPLFRAGIMQSGAM-VPSDPVDGTYGNEIYDLFVSSAGCGSASDK------ 274 Query: 343 MSCMRSVDAKTISVQQWNSYSGILSFPS-----APTIDGAFLPADPMTLMKTADLKDYDI 397 ++C+RS + T+ + N+ G L++ S P DG + D L++ + Sbjct: 275 LACLRSASSDTL-LDATNNTPGFLAYSSLRLSYLPRPDGKNITDDMYKLVRDGKYASVPV 333 Query: 398 LMGNVRDEGTYFLL 411 ++G+ DEGT F L Sbjct: 334 IIGDQNDEGTIFGL 347 >1THG-A nrPDB Length = 544 Score = 126 bits (316), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 140/523 (26%), Positives = 214/523 (40%), Gaps = 107/523 (20%) Query: 63 EVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLSATCVQ----------ERYEYF 112 +V + GIP+A PP+ DLRF+ P P + L A S C+Q ++ Sbjct: 20 KVDTFKGIPFADPPLNDLRFKHPQPFTGSYQGLKANDFSPACMQLDPGNSLTLLDKALGL 79 Query: 113 PGFSGEEIWNP-------NTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDH 165 EE P +++EDCLY+NV+ PA G P+ K Sbjct: 80 AKVIPEEFRGPLYDMAKGTVSMNEDCLYLNVFRPA------------GTKPDAK------ 121 Query: 166 LIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGN---VIVASFQYRVGA 222 LP+++WIYGG F+ GS+ N+ + ++ V+ S YR G Sbjct: 122 -------------LPVMVWIYGGAFVYGSSAAYPGNSYVKESINMGQPVVFVSINYRTGP 168 Query: 223 FGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSV 282 FGFL E N GL DQ + W+ DN FGG+P+ + +FGESAG+ SV Sbjct: 169 FGFLG-----GDAITAEGNTNAGLHDQRKGLEWVSDNIANFGGDPDKVMIFGESAGAMSV 223 Query: 283 NAQLM------SPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGK---ALINDCNCNAS 333 QL+ + + L ++QSG P+ H +S +I A C+ +AS Sbjct: 224 AHQLIAYGGDNTYNGKKLFHSAILQSGGP-LPY-HDSSSVGPDISYNRFAQYAGCDTSAS 281 Query: 334 MLKTNPAHVMSCMRSVDAKTISVQQWNSYS-----GILS--FPSAPTIDGAFLPADPMTL 386 T + C+RS + + Q NSY G+L P DG +P L Sbjct: 282 ANDT-----LECLRSKSSSVLHDAQ-NSYDLKDLFGLLPQFLGFGPRPDGNIIPDAAYEL 335 Query: 387 MKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAE 446 ++ + GN DEGT F +AT P K + + IF A++A Sbjct: 336 FRSGRYAKVPYISGNQEDEGTAFAPVAL-------NATTTPHVK--KWLQYIFYDASEAS 386 Query: 447 REAIIFQY--TSWEGNP---GYQNQ-----QQIGRAVGDHFFTCPTNEYAQALAERGASV 496 + ++ Y T G+P G N +++ + D F P A + + Sbjct: 387 IDRVLSLYPQTLSVGSPFRTGILNALTPQFKRVAAILSDMLFQSP--RRVMLSATKDVNR 444 Query: 497 HYYYFTHRTSTSLWGEWMGVLHGDEIEYFFG---QPLNNSLQY 536 Y TH + ++G HG+E+ + F P N+ L+Y Sbjct: 445 WTYLSTHLHNLV---PFLGTFHGNELIFQFNVNIGPANSYLRY 484 >2C7B-A nrPDB Length = 311 Score = 45.8 bits (107), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 30/101 (29%), Positives = 49/101 (48%), Gaps = 16/101 (15%) Query: 178 GLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFA 237 GLP +++ +GGGF+ GS + ++ + + +V S YR LAPE A Sbjct: 72 GLPAVLYYHGGGFVFGSIETHDHICRRLSRLSDSVVVSVDYR--------LAPEYKFPTA 123 Query: 238 EEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAG 278 E D A++W+ D A G +P+ + + G+SAG Sbjct: 124 VE--------DAYAALKWVADRADELGVDPDRIAVAGDSAG 156 >4WY5-A nrPDB Length = 332 Score = 44.3 bits (103), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 32/116 (27%), Positives = 53/116 (45%), Gaps = 16/116 (13%) Query: 179 LPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAE 238 LP+LI+++GGGF+ GS I + NV+ Y L+P Sbjct: 80 LPVLIFLHGGGFVFGSKYTHIKPVRDLTVKANVVTVFVDYS--------LSP-------- 123 Query: 239 EAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGL 294 EA + + AI W+++NA + N E + + G+SAG++ A + +GL Sbjct: 124 EAKFPTAIEEIYAAILWVRENASSLNINAEALAVAGDSAGATLSAAVSIYAKEKGL 179 >2O7R-A nrPDB Length = 338 Score = 41.2 bits (95), Expect = 0.001, Method: Compositional matrix adjust. Identities = 40/140 (28%), Positives = 64/140 (45%), Gaps = 47/140 (33%) Query: 179 LPILIWIYGGGFMTGSATLDIYNADI--MAAVGNVIVASFQYRVGAFGFLHLAPE--MPS 234 LP++++ +GGGF+ SA I++ MA V++AS YR LAPE +P+ Sbjct: 83 LPLVVYFHGGGFILFSAASTIFHDFCCEMAVHAGVVIASVDYR--------LAPEHRLPA 134 Query: 235 EFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLF---------GESAG------- 278 + D A++W+KD+ EW+T F GESAG Sbjct: 135 AYD----------DAMEALQWIKDS------RDEWLTNFADFSNCFIMGESAGGNIAYHA 178 Query: 279 ---SSSVNAQLMSPVTRGLV 295 +++V +L+ +GLV Sbjct: 179 GLRAAAVADELLPLKIKGLV 198 >2YH2-A nrPDB Length = 313 Score = 38.5 bits (88), Expect = 0.010, Method: Compositional matrix adjust. Identities = 29/100 (29%), Positives = 44/100 (44%), Gaps = 16/100 (16%) Query: 179 LPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAE 238 LP +++ +GGGF+ GS + +A + +V S YR LAPE A Sbjct: 76 LPAVVYYHGGGFVLGSVETHDHVCRRLANLSGAVVVSVDYR--------LAPEHKFPAAV 127 Query: 239 EAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAG 278 E D A +W+ DN G + + + G+SAG Sbjct: 128 E--------DAYDAAKWVADNYDKLGVDNGKIAVAGDSAG 159 >5AOA-A nrPDB Length = 286 Score = 36.6 bits (83), Expect = 0.036, Method: Compositional matrix adjust. Identities = 28/108 (25%), Positives = 48/108 (44%), Gaps = 15/108 (13%) Query: 182 LIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAP 241 +++ +GGG+ +GS + A G V +A+ YRVG+ + +A Sbjct: 47 IVFFFGGGWQSGSPAQFRPQCEYFAGRGMVAMAA-DYRVGSRHNVKVAD----------- 94 Query: 242 GNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSP 289 + D AIRW++ +A G +P+ + G SAG +M P Sbjct: 95 ---CVADAKSAIRWVRQHAAELGVDPQKIVASGGSAGGHLAACTVMVP 139 >5L2P-A nrPDB Length = 306 Score = 36.2 bits (82), Expect = 0.048, Method: Compositional matrix adjust. Identities = 33/112 (29%), Positives = 50/112 (44%), Gaps = 18/112 (16%) Query: 173 QNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEM 232 + T NGL ++ +GG ++ GS + + I++ V S YR LAPE Sbjct: 71 KRTNNGL--VMHFHGGAWILGSIETEDAISRILSNSCECTVISVDYR--------LAPEY 120 Query: 233 PSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNA 284 A ++D AI W +DNA G + + + FG SAG + V A Sbjct: 121 KFPTA--------VYDCFNAIVWARDNAGELGIDKDKIATFGISAGGNLVAA 164 >4Q3K-A nrPDB Length = 260 Score = 33.5 bits (75), Expect = 0.32, Method: Compositional matrix adjust. Identities = 16/33 (48%), Positives = 21/33 (63%) Query: 246 LWDQALAIRWLKDNAHAFGGNPEWMTLFGESAG 278 L D A+ +LKDNAHA NP+ + + G SAG Sbjct: 104 LIDAEDALSYLKDNAHALHINPDKIAVIGFSAG 136 >5I8Q-A nrPDB Length = 767 Score = 33.1 bits (74), Expect = 0.44, Method: Compositional matrix adjust. Identities = 23/82 (28%), Positives = 39/82 (47%), Gaps = 9/82 (10%) Query: 75 PPVEDLRFRKPVP----AEPWHGVLDATGLSATCVQER---YEYFPGFSGEEIWNPNTNV 127 PP + R +P P P V+ +T ++ T + Y PGFS ++++NP V Sbjct: 349 PPHQQQRIFEPAPESHNGRPGRKVVISTNIAETSLTIDGIVYVVDPGFSKQKVYNPRIRV 408 Query: 128 SEDCLYINVWAPAKARLRHGRG 149 + L ++ + A A+ R GR Sbjct: 409 --ESLLVSPISKASAQQRAGRA 428 >6ID1-V nrPDB Length = 795 Score = 32.3 bits (72), Expect = 0.73, Method: Compositional matrix adjust. Identities = 20/83 (24%), Positives = 38/83 (45%), Gaps = 10/83 (12%) Query: 75 PPVEDLRFRKPVPAEPWHGVLDATGLSATCVQER--------YEYFPGFSGEEIWNPNTN 126 PP + R +P P + +G + + +T + E + PGF+ ++++NP Sbjct: 393 PPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIR 452 Query: 127 VSEDCLYINVWAPAKARLRHGRG 149 V + L + + A A+ R GR Sbjct: 453 V--ESLLVTAISKASAQQRAGRA 473 >5XDR-A nrPDB Length = 690 Score = 32.0 bits (71), Expect = 0.82, Method: Compositional matrix adjust. Identities = 27/105 (25%), Positives = 45/105 (42%), Gaps = 12/105 (11%) Query: 55 RSVTVQGREVHVYTGIPY--AKPPVEDLRFRKPVPAEPWHGVLDATGLSATCVQER---- 108 R V G EV IP PP + R +P P + +G + + +T + E Sbjct: 266 REVDDLGPEVGDIKIIPLYSTLPPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTI 325 Query: 109 ----YEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRG 149 + PGF+ ++++NP V + L + + A A+ R GR Sbjct: 326 DGVVFVIDPGFAKQKVYNPRIRV--ESLLVTAISKASAQQRAGRA 368 >5D0U-A nrPDB Length = 714 Score = 31.6 bits (70), Expect = 1.2, Method: Compositional matrix adjust. Identities = 15/37 (40%), Positives = 23/37 (62%), Gaps = 2/37 (5%) Query: 113 PGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRG 149 PGFS ++I+NP T V + L ++ + A A+ R GR Sbjct: 341 PGFSKQKIYNPRTRV--ESLLVSPISKASAQQRAGRA 375 >6AAE-A nrPDB Length = 317 Score = 30.4 bits (67), Expect = 2.3, Method: Compositional matrix adjust. Identities = 30/111 (27%), Positives = 50/111 (45%), Gaps = 20/111 (18%) Query: 172 PQNTTNGLPILIWIYGGGFMTGSATLDIYNADI--MAAVGNVIVASFQYRVGAFGFLHLA 229 P++ ++++ +GGG++ G TLD ++ +A V S YR LA Sbjct: 65 PEDADERPALMVYYHGGGWVIG--TLDTHDGTCRALAQKSGCAVLSIAYR--------LA 114 Query: 230 PEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSS 280 PE + AP D A+ W K NA G + + + + G+SAG + Sbjct: 115 PE----YRYPAPAE----DCYDALVWAKQNAATLGVDGDRLAVGGDSAGGN 157 >5G2V-A nrPDB Length = 534 Score = 30.0 bits (66), Expect = 3.1, Method: Compositional matrix adjust. Identities = 17/43 (39%), Positives = 25/43 (58%), Gaps = 5/43 (11%) Query: 411 LYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQ 453 Y+ ID ++ D A PR+ MNNIFGKA A+++ + Q Sbjct: 465 FYNDIDEWEMYDMKADPRE-----MNNIFGKAEYAKKQKELMQ 502 >5LP7-H nrPDB Length = 393 Score = 29.6 bits (65), Expect = 4.5, Method: Compositional matrix adjust. Identities = 13/30 (43%), Positives = 19/30 (63%) Query: 542 ELGKRMLSAVIEFAKTGNPAQDGEEWPNFS 571 ELGKR L+ ++ F+ TG PA + P F+ Sbjct: 267 ELGKRPLATILGFSTTGMPAHELAAAPGFA 296 >3EBL-A nrPDB Length = 365 Score = 29.3 bits (64), Expect = 5.9, Method: Compositional matrix adjust. Identities = 20/78 (25%), Positives = 34/78 (43%), Gaps = 2/78 (2%) Query: 144 LRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNA- 202 +R R A G+ G A T ++ P++I+ +GG F+ SA+ IY++ Sbjct: 77 VRIYRAAAEGDAEEGAAAVTRPILEFLTDAPAAEPFPVIIFFHGGSFVHSSASSTIYDSL 136 Query: 203 -DIMAAVGNVIVASFQYR 219 + +V S YR Sbjct: 137 CRRFVKLSKGVVVSVNYR 154 >1RU4-A nrPDB Length = 400 Score = 28.5 bits (62), Expect = 9.5, Method: Compositional matrix adjust. Identities = 19/59 (32%), Positives = 28/59 (47%), Gaps = 2/59 (3%) Query: 443 TQAEREAIIFQYTSWEGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYF 501 TQ + I F + +G P Y GRAV D F+ P +++ QA + Y+YF Sbjct: 63 TQGKGNTITFNKSGKDGAPIYVAAANCGRAVFD--FSFPDSQWVQASYGFYVTGDYWYF 119 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 1QON-A nrPDB 793 0.0 5HQ3-A nrPDB 711 0.0 6QAA-A nrPDB 700 0.0 6EMI-A nrPDB 698 0.0 2X8B-A nrPDB 697 0.0 1Q83-A nrPDB 692 0.0 2W6C-X nrPDB 687 0.0 4QWW-A nrPDB 679 0.0 5YDJ-A nrPDB 649 0.0 5YDI-A nrPDB 641 0.0 2WQZ-A nrPDB 600 e-172 3BIX-A nrPDB 585 e-167 5V5V-A nrPDB 583 e-166 1K4Y-A nrPDB 528 e-150 5FV4-A nrPDB 520 e-148 1MX5-A nrPDB 515 e-146 6H18-A nrPDB 512 e-145 1AKN-A nrPDB 500 e-142 1C7J-A nrPDB 445 e-125 3RAR-A nrPDB 394 e-110 5THM-A nrPDB 392 e-109 1LLF-A nrPDB 391 e-109 1GZ7-A nrPDB 387 e-108 1THG-A nrPDB 379 e-105 4WY5-A nrPDB 106 3e-23 2C7B-A nrPDB 104 2e-22 2O7R-A nrPDB 85 9e-17 Sequences not found previously or not previously below threshold: 2YH2-A nrPDB 94 2e-19 6AAE-A nrPDB 73 5e-13 4WY8-A nrPDB 71 2e-12 5L2P-A nrPDB 71 2e-12 3AIM-A nrPDB 68 1e-11 4V2I-A nrPDB 68 2e-11 3EBL-A nrPDB 65 1e-10 5AOA-A nrPDB 63 5e-10 3WJ2-A nrPDB 61 2e-09 2ZSH-A nrPDB 58 1e-08 4KRY-A nrPDB 51 1e-06 3GA7-A nrPDB 48 2e-05 4Q3K-A nrPDB 43 3e-04 3O4I-A nrPDB 42 7e-04 4BZW-A nrPDB 39 0.006 5YP1-A nrPDB 39 0.007 3FCX-A nrPDB 35 0.096 4E11-A nrPDB 34 0.18 3T5Y-A nrPDB 33 0.32 4Q1V-A nrPDB 33 0.47 5X6S-A nrPDB 32 0.86 2ECF-A nrPDB 31 1.4 2AE2-A nrPDB 31 2.0 1VBH-A nrPDB 31 2.1 2EEP-A nrPDB 30 3.0 4HXF-B nrPDB 29 6.3 2BRG-A nrPDB 29 6.8 4V2P-A nrPDB 29 9.3 >1QON-A nrPDB Length = 585 Score = 793 bits (2048), Expect = 0.0, Method: Composition-based stats. Identities = 585/585 (100%), Positives = 585/585 (100%) Query: 39 VIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDAT 98 VIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDAT Sbjct: 1 VIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDAT 60 Query: 99 GLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNG 158 GLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNG Sbjct: 61 GLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNG 120 Query: 159 KQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQY 218 KQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQY Sbjct: 121 KQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQY 180 Query: 219 RVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAG 278 RVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAG Sbjct: 181 RVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAG 240 Query: 279 SSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTN 338 SSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTN Sbjct: 241 SSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTN 300 Query: 339 PAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDIL 398 PAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDIL Sbjct: 301 PAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDIL 360 Query: 399 MGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWE 458 MGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWE Sbjct: 361 MGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWE 420 Query: 459 GNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLH 518 GNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLH Sbjct: 421 GNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLH 480 Query: 519 GDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDGEEWPNFSKEDPVYY 578 GDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDGEEWPNFSKEDPVYY Sbjct: 481 GDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDGEEWPNFSKEDPVYY 540 Query: 579 IFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWAGTCDGDSGSAS 623 IFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWAGTCDGDSGSAS Sbjct: 541 IFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWAGTCDGDSGSAS 585 >5HQ3-A nrPDB Length = 548 Score = 711 bits (1834), Expect = 0.0, Method: Composition-based stats. Identities = 224/588 (38%), Positives = 320/588 (54%), Gaps = 51/588 (8%) Query: 38 GVID-RLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLD 96 G D L+V T G +RG +T G V + GIP+A+PPV RFR P P +PW GV D Sbjct: 3 GREDAELLVTTRGGRLRGIRLTTPGGPVSAFLGIPFAEPPVGPRRFRPPEPKQPWSGVWD 62 Query: 97 ATGLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHP 156 AT C Q +PGF G E+WNPN N+SEDCLY+NVW P Sbjct: 63 ATTFQNVCYQYVDTLYPGFEGTEMWNPNRNLSEDCLYLNVWTPYP--------------- 107 Query: 157 NGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASF 216 N P+++WIYGGGF +GS++LD+Y+ + V++ S Sbjct: 108 -----------------RPKNPAPVMVWIYGGGFYSGSSSLDVYDGRFLVRTERVVLVSM 150 Query: 217 QYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGES 276 YRVGAFGFL L + EAPGNVGL DQ LA++W+++N AFGG+P +TLFGES Sbjct: 151 NYRVGAFGFLALP------GSREAPGNVGLLDQRLALQWVQENIAAFGGDPTSVTLFGES 204 Query: 277 AGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLK 336 AG++SV L+SP +RGL R ++QSG NAPW++++ E+A L C Sbjct: 205 AGAASVGMHLLSPPSRGLFHRAILQSGAPNAPWAYVSREEARRRALQLAKLVGCPPGGTG 264 Query: 337 TNPAHVMSCMRSVDAKTISVQQWN--SYSGILSFPSAPTIDGAFLPADPMTLMKTADLKD 394 N +++C+R+ + + +W+ + F P +DG FLP P L+ D K Sbjct: 265 GNDTELVACLRNRPPQELVNHEWHVLPQESVFRFSFVPVVDGDFLPDTPEALINNGDFKG 324 Query: 395 YDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQY 454 D+L+G +DEG+YFL+Y F KD+ + + R+++LE + + + EAI+ Y Sbjct: 325 LDVLVGVNKDEGSYFLVYG-APGFSKDNESLISREEFLEGVRVGVPQVSDLAAEAIVLHY 383 Query: 455 TSW--EGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGE 512 T W +P +N+ + VGDH CP ++AQ A GA V+ Y F HR+ST W E Sbjct: 384 TDWLHPEDPA-KNRDALSDVVGDHNVICPVAQFAQRYAANGARVYAYVFEHRSSTLPWPE 442 Query: 513 WMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQD----GEEWP 568 WMGV HG EIE+ FG PL+ S Y E+ +R++ FA+TG+P + +WP Sbjct: 443 WMGVPHGYEIEFIFGIPLDPSRNYTKEEKIFARRLMRYWANFARTGDPNEPRDPKAPQWP 502 Query: 569 NFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWAGTCD 616 ++ ++ Y S D + ++ RG A C+FWN +LPK+ S T D Sbjct: 503 PYTADEQKY--VSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLD 548 >6QAA-A nrPDB Length = 557 Score = 700 bits (1807), Expect = 0.0, Method: Composition-based stats. Identities = 220/588 (37%), Positives = 318/588 (54%), Gaps = 52/588 (8%) Query: 27 LVLSLHLSGVCGVIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPV 86 +L L G D +++ T +G VRG +TV G V + GIPYA+PP+ LRF+KP Sbjct: 16 FLLLCMLIGKSHTEDDIIIATKNGKVRGMQLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQ 75 Query: 87 PAEPWHGVLDATGLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRH 146 W + +AT + +C Q + FPGF G E+WNPNT++SEDCLY+NVW PA Sbjct: 76 SLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAP----- 130 Query: 147 GRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMA 206 P+N T +LIWIYGGGF TG+++L +Y+ +A Sbjct: 131 ------------------------KPKNAT----VLIWIYGGGFQTGTSSLHVYDGKFLA 162 Query: 207 AVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGN 266 V VIV S YRVGA GFL L EAPGN+GL+DQ LA++W++ N AFGGN Sbjct: 163 RVERVIVVSMNYRVGALGFLAL------PGNPEAPGNMGLFDQQLALQWVQKNIAAFGGN 216 Query: 267 PEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALIN 326 P+ +TLFGESAG++SV+ L+SP + L R ++QSG+ NAPW+ + +A L Sbjct: 217 PKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAK 276 Query: 327 DCNCNASMLKTNPAHVMSCMRSVDAKTISVQQ--WNSYSGILSFPSAPTIDGAFLPADPM 384 C+ + N ++ C+R+ D + I + + Y LS PT+DG FL P Sbjct: 277 LTGCS----RENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPD 332 Query: 385 TLMKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQ 444 L++ K IL+G +DEGT FL+Y F KD+ + + R ++ E + F ++ Sbjct: 333 ILLELGQFKKTQILVGVNKDEGTAFLVYG-APGFSKDNNSIITRKEFQEGLKIFFPGVSE 391 Query: 445 AEREAIIFQYTSWEGNPGYQN-QQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTH 503 +E+I+F YT W + +N ++ +G VGD+ F CP E+ + +E G + +YYF H Sbjct: 392 FGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEH 451 Query: 504 RTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQD 563 R+S W EWMGV+HG EIE+ FG PL QY E L + ++ FAK GNP + Sbjct: 452 RSSKLPWPEWMGVMHGYEIEFVFGLPLERRDQYTKAEEILSRSIVKRWANFAKYGNPQET 511 Query: 564 GEE---WPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKV 608 + WP F + Y +T+ ++ A +C FW + PKV Sbjct: 512 QNQSTSWPVFKSTEQKYLTLNTEST--RIMTKLRAQQCRFWTSFFPKV 557 >6EMI-A nrPDB Length = 532 Score = 698 bits (1801), Expect = 0.0, Method: Composition-based stats. Identities = 225/575 (39%), Positives = 322/575 (56%), Gaps = 52/575 (9%) Query: 40 IDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATG 99 D +++ T +G VRG ++TV G V + GIPYA+PP+ LRF+KP P W G+ +AT Sbjct: 4 EDDIIITTKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQPLTKWSGIWNATK 63 Query: 100 LSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGK 159 + +C+Q FPGF G E+WNPNT++SEDCLY+NVW PA Sbjct: 64 YANSCMQNIDTSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAP------------------ 105 Query: 160 QADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYR 219 P+N T +++WIYGGGF TG+++L +Y+ +A V VIV S YR Sbjct: 106 -----------KPKNAT----VMVWIYGGGFQTGTSSLPVYDGKFLARVERVIVVSMNYR 150 Query: 220 VGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGS 279 VGA GFL L EAPGN+GL+DQ LA++W++DN AFGG+P +TLFGESAG+ Sbjct: 151 VGALGFLALP------GNPEAPGNMGLFDQQLALKWVQDNIAAFGGDPNRVTLFGESAGA 204 Query: 280 SSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNP 339 +SV+ L+SP + L R ++QSG+ NAPW+ M+ E+A L C+ + N Sbjct: 205 ASVSLHLLSPGSHPLFTRAILQSGSANAPWAVMSPEEARNRTLNLAKLLGCS----RENE 260 Query: 340 AHVMSCMRSVDAKTISVQQ--WNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDI 397 ++ C+R+ D + I + YS LS PT+DG FL P TL++ K I Sbjct: 261 TEIIKCLRNKDPQEILDNEAFVVPYSTPLSVNFGPTVDGDFLTDMPDTLLELGQFKKTQI 320 Query: 398 LMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSW 457 L+G +DEGT FL+Y F KD+ + + R ++ E + F ++ +E+I+F YT W Sbjct: 321 LVGVNKDEGTAFLVYG-APGFSKDNDSIITRKEFQEGLKVFFPNVSEFGKESILFHYTDW 379 Query: 458 EGNPGYQN-QQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGV 516 E +N + + VGD+FF CP E+A+ AE G + ++YYF HR+S W EWMGV Sbjct: 380 EDEDRPENYRDALAEVVGDYFFICPALEFAKKYAEHGNNAYFYYFEHRSSKLPWPEWMGV 439 Query: 517 LHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQ---DGEEWPNFSKE 573 +HG EIE+ FG PL L Y E L + ++ FAK GNP + + +WP F Sbjct: 440 MHGYEIEFVFGLPLERRLNYTKEEEILSREIMRRWANFAKYGNPNETQNNSTQWPVFKPT 499 Query: 574 DPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKV 608 + Y +T+ ++ A C FWN + PKV Sbjct: 500 EQKYLTLNTESS--RIMTKLRAQHCRFWNSFFPKV 532 >2X8B-A nrPDB Length = 583 Score = 697 bits (1798), Expect = 0.0, Method: Composition-based stats. Identities = 211/588 (35%), Positives = 307/588 (52%), Gaps = 51/588 (8%) Query: 38 GVID-RLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLD 96 G D L+V G +RG + G V + GIP+A+PP+ RF P P +PW GV+D Sbjct: 2 GREDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVD 61 Query: 97 ATGLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHP 156 AT + C Q +PGF G E+WNPN +SEDCLY+NVW P Sbjct: 62 ATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYP--------------- 106 Query: 157 NGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASF 216 T+ P+L+WIYGGGF +G+++LD+Y+ + ++ S Sbjct: 107 -----------------RPTSPTPVLVWIYGGGFYSGASSLDVYDGRFLVQAERTVLVSM 149 Query: 217 QYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGES 276 YRVGAFGFL L + EAPGNVGL DQ LA++W+++N AFGG+P +TLFGES Sbjct: 150 NYRVGAFGFLALP------GSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGES 203 Query: 277 AGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLK 336 AG++SV L+SP +RGL R ++QSG N PW+ + +A L + C Sbjct: 204 AGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCPPGGTG 263 Query: 337 TNPAHVMSCMRSVDAKTISVQQWN--SYSGILSFPSAPTIDGAFLPADPMTLMKTADLKD 394 N +++C+R+ A+ + +W+ + F P +DG FL P L+ D Sbjct: 264 GNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHG 323 Query: 395 YDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQY 454 +L+G V+DEG+YFL+Y F KD+ + + R ++L + + + EA++ Y Sbjct: 324 LQVLVGVVKDEGSYFLVYG-APGFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHY 382 Query: 455 TSW--EGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGE 512 T W +P ++ + VGDH CP + A LA +GA V+ Y F HR ST W Sbjct: 383 TDWLHPEDPARL-REALSDVVGDHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPL 441 Query: 513 WMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQD----GEEWP 568 WMGV HG EIE+ FG PL+ S Y E+ +R++ FA+TG+P + +WP Sbjct: 442 WMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTGDPNEPRDPKAPQWP 501 Query: 569 NFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWAGTCD 616 ++ Y S D + ++ RG A C+FWN +LPK+ S T D Sbjct: 502 PYTAGAQQY--VSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLD 547 >1Q83-A nrPDB Length = 580 Score = 692 bits (1785), Expect = 0.0, Method: Composition-based stats. Identities = 217/588 (36%), Positives = 309/588 (52%), Gaps = 51/588 (8%) Query: 38 GVIDR-LVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLD 96 G D L+V+ G +RG + G V + GIP+A+PPV RF P P PW GVLD Sbjct: 33 GREDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLD 92 Query: 97 ATGLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHP 156 AT C Q +PGF G E+WNPN +SEDCLY+NVW P Sbjct: 93 ATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYP--------------- 137 Query: 157 NGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASF 216 + P+LIWIYGGGF +G+A+LD+Y+ +A V ++ S Sbjct: 138 -----------------RPASPTPVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSM 180 Query: 217 QYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGES 276 YRVG FGFL L + EAPGNVGL DQ LA++W+++N AFGG+P +TLFGES Sbjct: 181 NYRVGTFGFLALP------GSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGES 234 Query: 277 AGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLK 336 AG++SV ++S +R L R ++QSGT N PW+ +++ +A L C Sbjct: 235 AGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAG 294 Query: 337 TNPAHVMSCMRSVDAKTISVQQWN--SYSGILSFPSAPTIDGAFLPADPMTLMKTADLKD 394 N +++C+R+ A+ + +W+ I F P +DG FL P L+ T D +D Sbjct: 295 GNDTELIACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQD 354 Query: 395 YDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQY 454 +L+G V+DEG+YFL+Y + F KD+ + + R ++L + +A+ EA++ Y Sbjct: 355 LQVLVGVVKDEGSYFLVYG-VPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHY 413 Query: 455 TSW--EGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGE 512 T W +P + + + VGDH CP + A LA +GA V+ Y F HR ST W Sbjct: 414 TDWLHPEDPTHL-RDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPL 472 Query: 513 WMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQD----GEEWP 568 WMGV HG EIE+ FG PL+ SL Y ER +R++ FA+TG+P +WP Sbjct: 473 WMGVPHGYEIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWP 532 Query: 569 NFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWAGTCD 616 ++ Y + ++ RG A C+FWN +LPK+ S T D Sbjct: 533 PYTTAAQQYVSLNLKP--LEVRRGLRAQTCAFWNRFLPKLLSATDTLD 578 >2W6C-X nrPDB Length = 586 Score = 687 bits (1772), Expect = 0.0, Method: Composition-based stats. Identities = 211/583 (36%), Positives = 314/583 (53%), Gaps = 53/583 (9%) Query: 42 RLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLS 101 L+V T SG V G V V + + GIP+A+PPV ++RFR+P P +PW GV +A+ Sbjct: 26 ELLVNTKSGKVMGTRVPVLSSHISAFLGIPFAEPPVGNMRFRRPEPKKPWSGVWNASTYP 85 Query: 102 ATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQA 161 C Q E FPGFSG E+WNPN +SEDCLY+N+W P+ Sbjct: 86 NNCQQYVDEQFPGFSGSEMWNPNREMSEDCLYLNIWVPSP-------------------- 125 Query: 162 DTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVG 221 P++TT +++WIYGGGF +GS+TLD+YN +A V++ S YRVG Sbjct: 126 ---------RPKSTT----VMVWIYGGGFYSGSSTLDVYNGKYLAYTEEVVLVSLSYRVG 172 Query: 222 AFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSS 281 AFGFL L ++EAPGNVGL DQ +A++W+ DN FGG+P+ +T+FGESAG +S Sbjct: 173 AFGFLALH------GSQEAPGNVGLLDQRMALQWVHDNIQFFGGDPKTVTIFGESAGGAS 226 Query: 282 VNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAH 341 V ++SP +R L +R ++QSG+ N PW+ ++ + L + NCN + Sbjct: 227 VGMHILSPGSRDLFRRAILQSGSPNCPWASVSVAEGRRRAVELGRNLNCNLNS----DEE 282 Query: 342 VMSCMRSVDAKTISVQQWN--SYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILM 399 ++ C+R + + +WN + I F P IDG F P +++ + + K IL+ Sbjct: 283 LIHCLREKKPQELIDVEWNVLPFDSIFRFSFVPVIDGEFFPTSLESMLNSGNFKKTQILL 342 Query: 400 GNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSW-E 458 G +DEG++FLLY F KD + + R+ ++ + A +A+ QYT W + Sbjct: 343 GVNKDEGSFFLLYG-APGFSKDSESKISREDFMSGVKLSVPHANDLGLDAVTLQYTDWMD 401 Query: 459 GNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLH 518 N G +N+ + VGDH CP + + G + Y+F HR S +W EWMGV+H Sbjct: 402 DNNGIKNRDGLDDIVGDHNVICPLMHFVNKYTKFGNGTYLYFFNHRASNLVWPEWMGVIH 461 Query: 519 GDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQD---GEEWPNFSKEDP 575 G EIE+ FG PL L Y E L +R++ FAKTGNP + +WP F+ ++ Sbjct: 462 GYEIEFVFGLPLVKELNYTAEEEALSRRIMHYWATFAKTGNPNEPHSQESKWPLFTTKEQ 521 Query: 576 VYYIFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWAGTCDGD 618 + +T+ K+ + C FWN +LPK+ + CDG+ Sbjct: 522 KFIDLNTEP--MKVHQRLRVQMCVFWNQFLPKLLNAT-ACDGE 561 >4QWW-A nrPDB Length = 542 Score = 679 bits (1752), Expect = 0.0, Method: Composition-based stats. Identities = 222/581 (38%), Positives = 321/581 (55%), Gaps = 52/581 (8%) Query: 38 GVIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDA 97 G L V T +G VRG S+ V V + GIP+A+PP+ +RF +P P +PW VLDA Sbjct: 1 GRAGELKVSTQTGSVRGLSLPVLDGHVSAFLGIPFAEPPLGRMRFLRPEPVKPWQHVLDA 60 Query: 98 TGLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPN 157 T C Q +PGF G E+WNPN +SEDCLY+N+W P+ P Sbjct: 61 TSYKPACYQMVDTSYPGFQGTEMWNPNRGMSEDCLYLNIWVPS---------------PR 105 Query: 158 GKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQ 217 K A P+L+WIYGGGF +G+A+LD+Y+ + NVI+ S Sbjct: 106 PKDA------------------PVLVWIYGGGFYSGAASLDVYDGRFLTYTQNVILVSLS 147 Query: 218 YRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESA 277 YRVGAFGFL L + EAPGN+GL DQ LA++W+++N H FGGNP +T+FGESA Sbjct: 148 YRVGAFGFLGLP------GSPEAPGNMGLLDQRLALQWIQNNIHPFGGNPRAVTVFGESA 201 Query: 278 GSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKT 337 G++SV L+S +R L +R ++QSG NAPW+ +T ++ L C Sbjct: 202 GAASVGMHLLSTQSRTLFQRAILQSGGPNAPWATVTPAESRGRAALLGKQLGC----HFN 257 Query: 338 NPAHVMSCMRSVDAKTISVQQWN--SYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDY 395 N + ++SC+RS + + + ++W+ Y I FP P IDG F P P ++ + + K+ Sbjct: 258 NDSELVSCLRSKNPQELIDEEWSVLPYKSIFRFPFVPVIDGDFFPDTPEAMLSSGNFKET 317 Query: 396 DILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYT 455 +L+G V+DEG+YFL+Y F KD+ + + R +LE + A +A++ QYT Sbjct: 318 QVLLGVVKDEGSYFLIYGL-PGFSKDNESLISRADFLEGVRMSVPHANDIATDAVVLQYT 376 Query: 456 SWEG-NPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWM 514 W+ + +N++ + VGDH CP ++A A+R + V+ Y F HR S LW WM Sbjct: 377 DWQDQDNREKNREALDDIVGDHNVICPVVQFANDYAKRNSKVYAYLFDHRASNLLWPPWM 436 Query: 515 GVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDGEE---WPNFS 571 GV HG EIE+ FG PLN+SL Y P E+EL +RM+ FA+TGNP ++ WP ++ Sbjct: 437 GVPHGYEIEFVFGLPLNDSLNYTPQEKELSRRMMRYWANFARTGNPTDPADKSGAWPTYT 496 Query: 572 KEDPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWA 612 P Y +T + A C+FWN +LPK+ + Sbjct: 497 ASQPQYVQLNTQPLATQ--PSLRAQICAFWNHFLPKLLNAT 535 >5YDJ-A nrPDB Length = 737 Score = 649 bits (1673), Expect = 0.0, Method: Composition-based stats. Identities = 224/584 (38%), Positives = 320/584 (54%), Gaps = 52/584 (8%) Query: 41 DRLVVQTSSGPVRGRSVTVQ-GREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATG 99 D LVV T G +RG +V G++V V+ GIPYA+PPV LRFR P PAE W GVL+ T Sbjct: 164 DPLVVNTDKGRIRGITVDAPSGKKVDVWLGIPYAQPPVGPLRFRHPRPAEKWTGVLNTTT 223 Query: 100 LSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGK 159 +CVQ F F G +WNPNT +SEDCLYINV AP P K Sbjct: 224 PPNSCVQIVDTVFGDFPGATMWNPNTPLSEDCLYINVVAP---------------RPRPK 268 Query: 160 QADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYR 219 A +++WI+GGGF +G+ATLD+Y+ +A+ NVIV S QYR Sbjct: 269 NAA------------------VMLWIFGGGFYSGTATLDVYDHRALASEENVIVVSLQYR 310 Query: 220 VGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGS 279 V + GFL L EAPGN GL+DQ LA+RW++DN H FGG+P +TLFGESAG+ Sbjct: 311 VASLGFLFL-------GTPEAPGNAGLFDQNLALRWVRDNIHRFGGDPSRVTLFGESAGA 363 Query: 280 SSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNP 339 SV+ L+S ++R L +R ++QSG+ APW+ ++ E+A L C K + Sbjct: 364 VSVSLHLLSALSRDLFQRAILQSGSPTAPWALVSREEATLRALRLAEAVGCPHEPSKLSD 423 Query: 340 AHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILM 399 A + C+R D + +W + GI FP P +DGAFL P + + K +IL Sbjct: 424 A--VECLRGKDPHVLVNNEWGTL-GICEFPFVPVVDGAFLDETPQRSLASGRFKKTEILT 480 Query: 400 GNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEG 459 G+ +EG YF++Y + K++ + R+++L+ + + A R+AI+F+YT W Sbjct: 481 GSNTEEGYYFIIYYLTELLRKEEGVTVTREEFLQAVRELNPYVNGAARQAIVFEYTDWTE 540 Query: 460 -NPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLH 518 + N+ + + VGD+ FTC NE+AQ AE G +V+ Y +THR+ + W W GV+H Sbjct: 541 PDNPNSNRDALDKMVGDYHFTCNVNEFAQRYAEEGNNVYMYLYTHRSKGNPWPRWTGVMH 600 Query: 519 GDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPA-----QDGEEWPNFSKE 573 GDEI Y FG+PLN +L Y E++ ++++ FAKTGNP + EWP + Sbjct: 601 GDEINYVFGEPLNPTLGYTEDEKDFSRKIMRYWSNFAKTGNPNPNTASSEFPEWPKHTAH 660 Query: 574 DPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWAGTCDG 617 Y + + RGP +C+FW YLP++ + G Sbjct: 661 GRHYLELGLNTSF--VGRGPRLRQCAFWKKYLPQLVAATSNLPG 702 >5YDI-A nrPDB Length = 553 Score = 641 bits (1654), Expect = 0.0, Method: Composition-based stats. Identities = 224/584 (38%), Positives = 320/584 (54%), Gaps = 52/584 (8%) Query: 41 DRLVVQTSSGPVRGRSVTVQ-GREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATG 99 D LVV T G +RG +V G++V V+ GIPYA+PPV LRFR P PAE W GVL+ T Sbjct: 3 DPLVVNTDKGRIRGITVDAPSGKKVDVWLGIPYAQPPVGPLRFRHPRPAEKWTGVLNTTT 62 Query: 100 LSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGK 159 +CVQ F F G +WNPNT +SEDCLYINV AP P K Sbjct: 63 PPNSCVQIVDTVFGDFPGATMWNPNTPLSEDCLYINVVAP---------------RPRPK 107 Query: 160 QADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYR 219 A +++WI+GGGF +G+ATLD+Y+ +A+ NVIV S QYR Sbjct: 108 NAA------------------VMLWIFGGGFYSGTATLDVYDHRALASEENVIVVSLQYR 149 Query: 220 VGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGS 279 V + GFL L EAPGN GL+DQ LA+RW++DN H FGG+P +TLFGESAG+ Sbjct: 150 VASLGFLFL-------GTPEAPGNAGLFDQNLALRWVRDNIHRFGGDPSRVTLFGESAGA 202 Query: 280 SSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNP 339 SV+ L+S ++R L +R ++QSG+ APW+ ++ E+A L C K + Sbjct: 203 VSVSLHLLSALSRDLFQRAILQSGSPTAPWALVSREEATLRALRLAEAVGCPHEPSKLSD 262 Query: 340 AHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILM 399 A + C+R D + +W + GI FP P +DGAFL P + + K +IL Sbjct: 263 A--VECLRGKDPHVLVNNEWGTL-GICEFPFVPVVDGAFLDETPQRSLASGRFKKTEILT 319 Query: 400 GNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEG 459 G+ +EG YF++Y + K++ + R+++L+ + + A R+AI+F+YT W Sbjct: 320 GSNTEEGYYFIIYYLTELLRKEEGVTVTREEFLQAVRELNPYVNGAARQAIVFEYTDWTE 379 Query: 460 -NPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLH 518 + N+ + + VGD+ FTC NE+AQ AE G +V+ Y +THR+ + W W GV+H Sbjct: 380 PDNPNSNRDALDKMVGDYHFTCNVNEFAQRYAEEGNNVYMYLYTHRSKGNPWPRWTGVMH 439 Query: 519 GDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPA-----QDGEEWPNFSKE 573 GDEI Y FG+PLN +L Y E++ ++++ FAKTGNP + EWP + Sbjct: 440 GDEINYVFGEPLNPTLGYTEDEKDFSRKIMRYWSNFAKTGNPNPNTASSEFPEWPKHTAH 499 Query: 574 DPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPKVRSWAGTCDG 617 Y + + RGP +C+FW YLP++ + G Sbjct: 500 GRHYLELGLNTSF--VGRGPRLRQCAFWKKYLPQLVAATSNLPG 541 >2WQZ-A nrPDB Length = 588 Score = 600 bits (1547), Expect = e-172, Method: Composition-based stats. Identities = 155/622 (24%), Positives = 267/622 (42%), Gaps = 92/622 (14%) Query: 44 VVQTSSGPVRGRSVTVQG---REVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGL 100 VV T+ G +RG + V Y G+PYA PP + RF+ P P W G+ + T Sbjct: 16 VVNTNYGKIRGLRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQF 75 Query: 101 SATCVQERYEYFPGFSGEEIWNP---------NTNVSEDCLYINVWAPAKARLRHGRGAN 151 +A C Q E IW + +EDCLY+N++ P + + Sbjct: 76 AAVCPQHLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDDIH------ 129 Query: 152 GGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNV 211 + + P++++I+GG +M G+ ++ + I+A+ GNV Sbjct: 130 ----------------------DQNSKKPVMVYIHGGSYMEGTG--NMIDGSILASYGNV 165 Query: 212 IVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMT 271 IV + YR+G GFL S + A GN GL DQ A+RW+++N AFGG+P+ +T Sbjct: 166 IVITINYRLGILGFL-------STGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVT 218 Query: 272 LFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCN 331 +FG AG+S V+ +S + GL ++ ++QSGT + W+ + + + + L + CN Sbjct: 219 IFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWA--VNYQPAKYTRILADKVGCN 276 Query: 332 ASMLKTNPAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTAD 391 + ++ C+R+ + K + Q + ++ P IDG +P DP LM+ + Sbjct: 277 M----LDTTDMVECLRNKNYKELIQQTITPATYHIA--FGPVIDGDVIPDDPQILMEQGE 330 Query: 392 LKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMN-----NIFGKATQAE 446 +YDI++G + EG F+ D ++ P D + N + + Sbjct: 331 FLNYDIMLGVNQGEGLKFV-----DGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTL 385 Query: 447 REAIIFQYTSWEGNPGYQNQQQ-IGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRT 505 RE I F YT W + +++ + DH + P A A+ G+ ++Y F H Sbjct: 386 RETIKFMYTDWADKENPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHC 445 Query: 506 STSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRM-----LSAVIEFAKTGNP 560 + + W HGDE+ Y FG P+ + M ++ FAKTG+P Sbjct: 446 QSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDP 505 Query: 561 AQDGEE----------------WPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDY 604 Q + W ++ +D +Y ++ R A + +FW + Sbjct: 506 NQPVPQDTKFIHTKPNRFEEVAWSRYNPKDQLYLHIGLKPRVRDHYR---ATKVAFWLEL 562 Query: 605 LPKVRSWAGTCDGDSGSASISP 626 +P + + S + + P Sbjct: 563 VPHLHNLNEIFQYVSTTTKVPP 584 >3BIX-A nrPDB Length = 574 Score = 585 bits (1508), Expect = e-167, Method: Composition-based stats. Identities = 156/606 (25%), Positives = 259/606 (42%), Gaps = 92/606 (15%) Query: 40 IDRLVVQTSSGPVRGRSVTVQG---REVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLD 96 +D L V T+ G +RG + V + G+PYA PP + RF+ P P PW + + Sbjct: 9 VDPL-VTTNFGKIRGIKKELNNEILGPVIQFLGVPYAAPPTGEHRFQPPEPPSPWSDIRN 67 Query: 97 ATGLSATCVQERYEYFPGFSGEEIWNPN---------TNVSEDCLYINVWAPAKARLRHG 147 AT + C Q + +W N + SEDCLY+N++ P + +R Sbjct: 68 ATQFAPVCPQNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDDIRDS 127 Query: 148 RGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAA 207 G P++++I+GG +M G+ ++Y+ ++A+ Sbjct: 128 GG----------------------------PKPVMVYIHGGSYMEGTG--NLYDGSVLAS 157 Query: 208 VGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNP 267 GNVIV + YR+G GFL S + A GN GL D A+RW +N FGG+P Sbjct: 158 YGNVIVITVNYRLGVLGFL-------STGDQAAKGNYGLLDLIQALRWTSENIGFFGGDP 210 Query: 268 EWMTLFGESAGSSSVNAQLMSPVT-RGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALIN 326 +T+FG AG S VN +S + +GL +R + QSGT + W+ S + + + L Sbjct: 211 LRITVFGSGAGGSCVNLLTLSHYSEKGLFQRAIAQSGTALSSWA--VSFQPAKYARILAT 268 Query: 327 DCNCNASMLKTNPAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTL 386 CN S + ++ C++ K + Q ++ P IDG +P DP L Sbjct: 269 KVGCNVS----DTVELVECLQKKPYKELVDQDVQPARYHIA--FGPVIDGDVIPDDPQIL 322 Query: 387 MKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYL--EIMNNIF--GKA 442 M+ + +YDI++G + EG F+ + D DD + + ++N++ + Sbjct: 323 MEQGEFLNYDIMLGVNQGEGLKFVE----NIVDSDDGVSASDFDFAVSNFVDNLYGYPEG 378 Query: 443 TQAEREAIIFQYTSWEGNPGYQNQQQ-IGRAVGDHFFTCPTNEYAQALAERGASVHYYYF 501 RE I F YT W + +++ + DH + P A + G+ ++Y F Sbjct: 379 KDVLRETIKFMYTDWADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAF 438 Query: 502 THRTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRM-----LSAVIEFAK 556 H T W HGDE+ Y G P+ + P M ++ FAK Sbjct: 439 YHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAK 498 Query: 557 TGNPAQDGEE----------------WPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSF 600 TG+P Q + W +S++D +Y ++++ R A + + Sbjct: 499 TGDPNQPVPQDTKFIHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYR---ANKVNL 555 Query: 601 WNDYLP 606 W + +P Sbjct: 556 WLELVP 561 >5V5V-A nrPDB Length = 582 Score = 583 bits (1502), Expect = e-166, Method: Composition-based stats. Identities = 159/604 (26%), Positives = 264/604 (43%), Gaps = 73/604 (12%) Query: 44 VVQTSSGPVRGRSVTVQG---REVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGL 100 VV T+ G VRG + V + G+PYA PP+ RF+ P W GV +AT L Sbjct: 3 VVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTL 62 Query: 101 SATCVQERYEYFPGFSGEEIWNPN--------TNVSEDCLYINVWAPAKARLRHGRGANG 152 C Q + P + N N SEDCLY+N++ P + Sbjct: 63 PPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTE----------- 111 Query: 153 GEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVI 212 + P K+ D L + P++++++GG +M G+ ++++ ++AA GNVI Sbjct: 112 -DGPLTKKRDEATLNPPDTDIRDSGKKPVMLFLHGGSYMEGTG--NMFDGSVLAAYGNVI 168 Query: 213 VASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTL 272 VA+ YR+G GFL S + A GN GL DQ A+RWL +N FGG+PE +T+ Sbjct: 169 VATLNYRLGVLGFL-------STGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITI 221 Query: 273 FGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNA 332 FG AG+S VN ++S + GL ++ + QSGT + WS + + ++ + L C Sbjct: 222 FGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWS--VNYQPLKYTRLLAAKVGC-- 277 Query: 333 SMLKTNPAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADL 392 + + + C+R ++ + Q ++F +P DP LM+ + Sbjct: 278 --DREDSTEAVECLRRKSSRELVDQDVQPARYHIAFGPVVDG--DVVPDDPEILMQQGEF 333 Query: 393 KDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYL--EIMNNI--FGKATQAERE 448 +YD+L+G + EG F+ D + +D + + ++N+ + + RE Sbjct: 334 LNYDMLIGVNQGEGLKFVE----DSAESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRE 389 Query: 449 AIIFQYTSWEG-NPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTST 507 I F YT W + G ++ + DH + P A+ A+ + V++Y F H Sbjct: 390 TIKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQA 449 Query: 508 SLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRM-----LSAVIEFAKTGNPAQ 562 EW HGDE+ Y FG P+ + P M ++ FAKTG+P Q Sbjct: 450 EGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQ 509 Query: 563 DGEE----------------WPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDYLP 606 + W F+ ++ Y ++ R A + +FW + +P Sbjct: 510 PVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYR---ANKVAFWLELVP 566 Query: 607 KVRS 610 + + Sbjct: 567 HLHN 570 >1K4Y-A nrPDB Length = 534 Score = 528 bits (1359), Expect = e-150, Method: Composition-based stats. Identities = 157/585 (26%), Positives = 245/585 (41%), Gaps = 82/585 (14%) Query: 42 RLVVQTSSGPVRGRSVTVQG--REVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATG 99 VV T G V G+ V+++G + V V+ G+P+AKPP+ LRF P PAE W V + T Sbjct: 1 PPVVDTVHGKVLGKFVSLEGFAQPVAVFLGVPFAKPPLGSLRFAPPQPAESWSHVKNTTS 60 Query: 100 LSATCVQERYEYFPGFSGEEIW-----NPNTNVSEDCLYINVWAPAKARLRHGRGANGGE 154 C Q+ G E++ N SEDCLY+N++ PA R Sbjct: 61 YPPMCSQDAVS---GHMLSELFTNRKENIPLKFSEDCLYLNIYTPADLTKR--------- 108 Query: 155 HPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVA 214 LP+++WI+GGG M G A+ Y+ ++A NV+V Sbjct: 109 ----------------------GRLPVMVWIHGGGLMVGGAST--YDGLALSAHENVVVV 144 Query: 215 SFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFG 274 + QYR+G +GF S E + GN G DQ A+RW++DN FGG+P +T+FG Sbjct: 145 TIQYRLGIWGFF-------STGDEHSRGNWGHLDQVAALRWVQDNIANFGGDPGSVTIFG 197 Query: 275 ESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASM 334 ESAG SV+ L+SP+T+ L R + +SG S + + + + + + C Sbjct: 198 ESAGGQSVSILLLSPLTKNLFHRAISESGVALL--SSLFRKNTKSLAEKIAIEAGCKT-- 253 Query: 335 LKTNPAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAP---------TIDGAFLPADPMT 385 T A ++ C+R + + L P IDG LP P Sbjct: 254 --TTSAVMVHCLRQKTEEELMEVTLKMKFMALDLVGDPKENTAFLTTVIDGVLLPKAPAE 311 Query: 386 LMKTADLKDYDILMGNVRDEGTYFLLYDFIDY------FDKDDATALPRDKYLEIMNNIF 439 ++ ++G + E + + + Y D+ AT L Y + N+ Sbjct: 312 ILAEKKYNMLPYMVGINQQEFGWIIPMQMLGYPLSEGKLDQKTATELLWKSYPIV--NVS 369 Query: 440 GKATQAEREAIIFQYTSWEGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYY 499 + T E +Y +P + + + D F P+ A+ + GA + Y Sbjct: 370 KELTPVATE----KYLGGTDDP-VKKKDLFLDMLADLLFGVPSVNVARHHRDAGAPTYMY 424 Query: 500 YFTHRTSTSLWGEWMGVL--HGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKT 557 + +R S S V+ HGDEI G P E +L K ++ FA+ Sbjct: 425 EYRYRPSFSSDMRPKTVIGDHGDEIFSVLGAPFLKE-GATEEEIKLSKMVMKYWANFARN 483 Query: 558 GNPAQDG-EEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFW 601 GNP +G +WP + ++ I +T +KL +A W Sbjct: 484 GNPNGEGLPQWPAYDYKEGYLQIGATTQAAQKLKDKEVAFWTELW 528 >5FV4-A nrPDB Length = 544 Score = 520 bits (1340), Expect = e-148, Method: Composition-based stats. Identities = 160/591 (27%), Positives = 247/591 (41%), Gaps = 83/591 (14%) Query: 40 IDRLVVQTSSGPVRGRSVTVQG--REVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDA 97 VV T+ G V G+ V+++G + V V+ G+P+AKPP+ LRF P PAEPW V + Sbjct: 4 ASPPVVDTAQGRVLGKYVSLEGLAQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNT 63 Query: 98 TGLSATCVQERY--EYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEH 155 T C Q+ + SEDCLY+N++ PA R Sbjct: 64 TSYPPMCCQDPVAGQMTSDLFTNRKERLIPEFSEDCLYLNIYTPADLTKR---------- 113 Query: 156 PNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVAS 215 LP+++WI+GGG + G A+ Y+ +AA NV+V + Sbjct: 114 ---------------------GRLPVMVWIHGGGLVVGGAST--YDGLALAAHENVVVVA 150 Query: 216 FQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGE 275 QYR+G +GF S E + GN G DQ A+ W+++N FGG+P +T+FGE Sbjct: 151 IQYRLGIWGFF-------STGDEHSRGNWGHLDQVAALHWVQENIANFGGDPGSVTIFGE 203 Query: 276 SAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASML 335 SAG SV+ ++SP+ + L R + +SG + + + K + C Sbjct: 204 SAGGESVSVLVLSPLAKNLFHRAISESGVAFT--AGLVRKDMKAAAKQIAVLAGCKT--- 258 Query: 336 KTNPAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAP---------TIDGAFLPADPMTL 386 T A + C+R + L P +DG LP P + Sbjct: 259 -TTSAVFVHCLRQKSEDELLDLTLKMKFFALDLHGDPRESHPFLTTVVDGVLLPKMPEEI 317 Query: 387 MKTADLKDYDILMGNVRDEGTYFLLYDF-----IDYFDKDDATALPRDKYLEIMNNIFGK 441 + D ++G + E + L D+ AT+L Y + NI + Sbjct: 318 LAEKDFNTVPYIVGINKQEFGWLLPTMMGFPLSEGKLDQKTATSLLWKSYP--IANIPEE 375 Query: 442 ATQAEREAIIFQYTSWEGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYF 501 T + +Y +P + + +GD F P+ A+ + GA + Y F Sbjct: 376 LTPVATD----KYLGGTDDP-VKKKDLFLDLMGDVVFGVPSVTVARQHRDAGAPTYMYEF 430 Query: 502 THRTSTSLWGEWMGVL--HGDEIEYFFGQPLNNSLQYRPVERE--LGKRMLSAVIEFAKT 557 +R S S + V+ HGDEI FG P L+ E E L K ++ FA++ Sbjct: 431 QYRPSFSSDKKPKTVIGDHGDEIFSVFGAPF---LRGDAPEEEVSLSKTVMKFWANFARS 487 Query: 558 GNPAQDG-EEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPK 607 GNP +G WP + +E+ Y + + K +G +FWND L K Sbjct: 488 GNPNGEGLPHWPMYDQEEG-YLQIGVNTQAAKRLKG---EEVAFWNDLLSK 534 >1MX5-A nrPDB Length = 548 Score = 515 bits (1327), Expect = e-146, Method: Composition-based stats. Identities = 160/595 (26%), Positives = 249/595 (41%), Gaps = 86/595 (14%) Query: 38 GVIDRLVVQTSSGPVRGRSVTVQG--REVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVL 95 VV T G V G+ V+++G + V ++ GIP+AKPP+ LRF P PAEPW V Sbjct: 1 HPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVK 60 Query: 96 DATGLSATCVQERY--EYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGG 153 +AT C Q+ + N +SEDCLY+N++ PA + Sbjct: 61 NATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLNIYTPADLTKK-------- 112 Query: 154 EHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIV 213 N LP+++WI+GGG M G+A+ Y+ +AA NV+V Sbjct: 113 -----------------------NRLPVMVWIHGGGLMVGAAST--YDGLALAAHENVVV 147 Query: 214 ASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLF 273 + QYR+G +GF S E + GN G DQ A+RW++DN +FGGNP +T+F Sbjct: 148 VTIQYRLGIWGFF-------STGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIF 200 Query: 274 GESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNAS 333 GESAG SV+ ++SP+ + L R + +SG S + + V K L A Sbjct: 201 GESAGGESVSVLVLSPLAKNLFHRAISESGVALT--SVLVKKGDV---KPLAEQIAITAG 255 Query: 334 MLKTNPAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAP---------TIDGAFLPADPM 384 T A ++ C+R + + L P IDG L P Sbjct: 256 CKTTTSAVMVHCLRQKTEEELLETTLKMKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPE 315 Query: 385 TLMKTADLKDYDILMGNVRDEGTYFLLYDFI-----DYFDKDDATALPRDKY--LEIMNN 437 L + ++G + E + + D+ A +L Y + I Sbjct: 316 ELQAERNFHTVPYMVGINKQEFGWLIPMLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKE 375 Query: 438 IFGKATQAEREAIIFQYTSWEGNPGYQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVH 497 + +AT+ +Y + + + + D F P+ A+ + GA + Sbjct: 376 LIPEATE--------KYLGGTDD-TVKKKDLFLDLIADVMFGVPSVIVARNHRDAGAPTY 426 Query: 498 YYYFTHRTSTSLWGEWMGVL--HGDEIEYFFGQPLNNSLQYRPVERE--LGKRMLSAVIE 553 Y F +R S S + V+ HGDE+ FG P L+ E E L K ++ Sbjct: 427 MYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPF---LKEGASEEEIRLSKMVMKFWAN 483 Query: 554 FAKTGNPAQDG-EEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDYLPK 607 FA+ GNP +G WP +++++ I + +KL +FW + K Sbjct: 484 FARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLKDKE----VAFWTNLFAK 534 >6H18-A nrPDB Length = 547 Score = 512 bits (1318), Expect = e-145, Method: Composition-based stats. Identities = 161/578 (27%), Positives = 246/578 (42%), Gaps = 80/578 (13%) Query: 45 VQTSSGPVRG--RSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLSA 102 V T G V G + + + G V ++ GIP+A P P P W G L A Sbjct: 20 VYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPTKA---LENPQPHPGWQGTLKAKNFKK 76 Query: 103 TCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQAD 162 C+Q I +T EDCLY+N+W P Sbjct: 77 RCLQ-----------ATITQDSTYGDEDCLYLNIWVP----------------------- 102 Query: 163 TDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSA------TLDIYNADIMAAVGNVIVASF 216 + + LP++IWIYGG F+ GS +Y+ + +A GNVIV +F Sbjct: 103 -------QGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTF 155 Query: 217 QYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGES 276 YRVG GFL S PGN GL DQ +AI W+K N AFGG+P+ +TLFGES Sbjct: 156 NYRVGPLGFL-------STGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPDNITLFGES 208 Query: 277 AGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLK 336 AG +SV+ Q +SP +GL++R + QSG +PW + + + K + C Sbjct: 209 AGGASVSLQTLSPYNKGLIRRAISQSGVALSPW--VIQKNPLFWAKKVAEKVGCPVG--- 263 Query: 337 TNPAHVMSCMRSVDAKTISVQQWNS-----YSGILSFPSAPTIDGAFLPADPMTLMKTAD 391 + A + C++ D + +++ Y + P IDG F+P DP+ L + Sbjct: 264 -DAARMAQCLKVTDPRALTLAYKVPLAGLEYPMLHYVGFVPVIDGDFIPDDPINLYA--N 320 Query: 392 LKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAII 451 D D + G +G F D + +K + D Y + K + + Sbjct: 321 AADIDYIAGTNNMDGHIFASID-MPAINKGNKKVTEEDFYKLVSEFTITKGLRGAKTTFD 379 Query: 452 FQYTSWEGNPGYQNQQQ-IGRAVGDHFFTCPT-NEYAQALAE-RGASVHYYYFTHRTSTS 508 SW +P +N+++ + D F PT AQ A + A + Y F+H + Sbjct: 380 VYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIALAQHRANAKSAKTYAYLFSHPSRMP 439 Query: 509 LWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDG---- 564 ++ +W+G H D+I+Y FG+P YRP +R + K M++ FAKTG+P Sbjct: 440 VYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAKTGDPNMGDSAVP 499 Query: 565 EEWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWN 602 W ++ E+ Y + + R +W Sbjct: 500 THWEPYTTENSGYLEITKKMGSSSMKRSLRTNFLRYWT 537 >1AKN-A nrPDB Length = 579 Score = 500 bits (1286), Expect = e-142, Method: Composition-based stats. Identities = 159/605 (26%), Positives = 254/605 (41%), Gaps = 83/605 (13%) Query: 45 VQTSSGPVRG--RSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLSA 102 V T G V G + +++ G + ++ GIP+A P KP W G L A Sbjct: 6 VYTEGGFVEGVNKKLSLFGDSIDIFKGIPFAAAPKA---LEKPERHPGWQGTLKAKSFKK 62 Query: 103 TCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQAD 162 C+Q + +T +EDCLY+N+W P Sbjct: 63 RCLQ-----------ATLTQDSTYGNEDCLYLNIWVP----------------------- 88 Query: 163 TDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSA------TLDIYNADIMAAVGNVIVASF 216 + ++ LP++IWIYGG F+ G++ + +Y+ + +A GNVIV +F Sbjct: 89 -------QGRKEVSHDLPVMIWIYGGAFLMGASQGANFLSNYLYDGEEIATRGNVIVVTF 141 Query: 217 QYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGES 276 YRVG GFL S PGN GLWDQ +AI W+K N AFGG+P+ +TLFGES Sbjct: 142 NYRVGPLGFL-------STGDSNLPGNYGLWDQHMAIAWVKRNIEAFGGDPDNITLFGES 194 Query: 277 AGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLK 336 AG +SV+ Q +SP +GL+KR + QSG PW+ + + K + C Sbjct: 195 AGGASVSLQTLSPYNKGLIKRAISQSGVGLCPWA--IQQDPLFWAKRIAEKVGCPVD--- 249 Query: 337 TNPAHVMSCMRSVDAKTISVQQWNS-----YSGILSFPSAPTIDGAFLPADPMTLMKTAD 391 + + + C++ D + +++ Y + P IDG F+P DP+ L + Sbjct: 250 -DTSKMAGCLKITDPRALTLAYKLPLGSTEYPKLHYLSFVPVIDGDFIPDDPVNLYA--N 306 Query: 392 LKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAII 451 D D + G +G F+ D + + + D Y + K + Sbjct: 307 AADVDYIAGTNDMDGHLFVGMD-VPAINSNKQDVTEEDFYKLVSGLTVTKGLRGANATYE 365 Query: 452 FQYTSWEGNPGYQNQQQIG-RAVGDHFFTCPT-NEYAQALAE-RGASVHYYYFTHRTSTS 508 W + + +++ D F PT AQ + + A+ + Y F+ + Sbjct: 366 VYTEPWAQDSSQETRKKTMVDLETDILFLIPTKIAVAQHKSHAKSANTYTYLFSQPSRMP 425 Query: 509 LWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDGE--- 565 ++ +WMG H D+++Y FG+P L YR +R + K M++ FA+TG+P Sbjct: 426 IYPKWMGADHADDLQYVFGKPFATPLGYRAQDRTVSKAMIAYWTNFARTGDPNTGHSTVP 485 Query: 566 -EWPNFSKEDPVYYIFSTDDKIEKLARGPLAARCSFWNDY---LPKVRSWAGTCDGDSGS 621 W ++ ED Y + + FW LP V S + + Sbjct: 486 ANWDPYTLEDDNYLEINKQMDSNSMKLHLRTNYLQFWTQTYQALPTVTSAGASLLPPEDN 545 Query: 622 ASISP 626 + SP Sbjct: 546 SQASP 550 >1C7J-A nrPDB Length = 489 Score = 445 bits (1144), Expect = e-125, Method: Composition-based stats. Identities = 163/560 (29%), Positives = 238/560 (42%), Gaps = 88/560 (15%) Query: 44 VVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLSAT 103 +V T G V+G T G VH + GIPYAKPPV RF+ P P E W VLDAT Sbjct: 5 IVTTQYGKVKG--TTENG--VHKWKGIPYAKPPVGQWRFKAPEPPEVWEDVLDATAYGPV 60 Query: 104 CVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADT 163 C Q P + SEDCLY+NV+AP Sbjct: 61 CPQ------PSDLLSLSYTELPRQSEDCLYVNVFAP------------------------ 90 Query: 164 DHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAF 223 + LP+++WI+GG F G+ + +Y+ +AA G VIV + YR+G F Sbjct: 91 ---------DTPSQNLPVMVWIHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPF 141 Query: 224 GFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVN 283 GF+HL S F E N+GL DQA A++W+++N AFGG+P+ +T+FGESAG S+ Sbjct: 142 GFMHL-----SSFDEAYSDNLGLLDQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIA 196 Query: 284 AQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASM-LKTNPAHV 342 A L P +GL ++ +M+SG MT E+A A + N S + + Sbjct: 197 ALLAMPAAKGLFQKAIMESGASRT----MTKEQAASTAAAFLQVLGINESQLDRLHTVAA 252 Query: 343 MSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTADLKDYDILMGNV 402 +++ D I+ ++ I P +D LP +P + +L+G Sbjct: 253 EDLLKAADQLRIAEKE-----NIFQLFFQPALDPKTLPEEPEKSIAEGAASGIPLLIGTT 307 Query: 403 RDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTSWEGNPG 462 RDEG F D D + D LE GK AE+ A ++ + Sbjct: 308 RDEGYLFFTS------DSDVRSQETLDAALEYS---LGKPL-AEKAADLYPRSL------ 351 Query: 463 YQNQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLWGEWMGVLHGDEI 522 + V D F P +A A + A V Y F + + H E+ Sbjct: 352 ----ESQIHMVTDLLFWRPAVAFASAQSHY-APVWMYRFDWHPEKPPYNK---AFHALEL 403 Query: 523 EYFFGQPLNNSLQYRPVE-----RELGKRMLSAVIEFAKTGNPAQDGEEWPNFSKEDPVY 577 + FG L+ + E ++L + SA I FAKTGNP+ + WP + +E Sbjct: 404 PFVFGN-LDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAVNWPAYHEETRET 462 Query: 578 YIFSTDDKIEKLARGPLAAR 597 I ++ IE + Sbjct: 463 VILDSEITIENDPESEKRQK 482 >3RAR-A nrPDB Length = 534 Score = 394 bits (1011), Expect = e-110, Method: Composition-based stats. Identities = 137/547 (25%), Positives = 217/547 (39%), Gaps = 106/547 (19%) Query: 65 HVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLSATCVQER-----YEYFPGFSG-- 117 + GIP+A+PPV +LRF+ PVP T +C+Q+ E P + Sbjct: 21 EAFLGIPFAEPPVGNLRFKDPVPYSGSLDGQKFTSYGPSCMQQNPEGTYEENLPKAALDL 80 Query: 118 ---EEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQN 174 +++ + SEDCL INV P + Sbjct: 81 VMQSKVFEAVSPSSEDCLTINVVRPPGTK------------------------------- 109 Query: 175 TTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVG---NVIVASFQYRVGAFGFLHLAPE 231 LP+++WI+GGGF G + I ++ +I S YRV ++GFL Sbjct: 110 AGANLPVMLWIFGGGFEVGGTSTFPPAQMITKSIAMGKPIIHVSVNYRVSSWGFLA---- 165 Query: 232 MPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLM---- 287 E E N GL DQ L ++W+ DN AFGG+P +T+FGESAGS SV ++ Sbjct: 166 -GDEIKAEGSANAGLKDQRLGMQWVADNIAAFGGDPTKVTIFGESAGSMSVMCHILWNDG 224 Query: 288 --SPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSC 345 + + L + G+MQSG M P + EI L ++ C ++ K ++C Sbjct: 225 DNTYKGKPLFRAGIMQSGAM-VPSDAVDGIYGNEIFDLLASNAGCGSASDK------LAC 277 Query: 346 MRSVDAKTISVQQWNSYSGILSFPS-----APTIDGAFLPADPMTLMKTADLKDYDILMG 400 +R V + T+ N+ G L++ S P DG + D L++ + +++G Sbjct: 278 LRGVSSDTLEDAT-NNTPGFLAYSSLRLSYLPRPDGVNITDDMYALVREGKYANIPVIIG 336 Query: 401 NVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTS--WE 458 + DEGT+F + E F A+ AE + ++ Y + Sbjct: 337 DQNDEGTFFGTSSL---------NVTTDAQAREYFKQSFVHASDAEIDTLMTAYPGDITQ 387 Query: 459 GNP---GYQNQ-----QQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLW 510 G+P G N ++I +GD FT Y G Y F + + L Sbjct: 388 GSPFDTGILNALTPQFKRISAVLGDLGFTL-ARRYFLNHYTGGTK---YSFLSKQLSGL- 442 Query: 511 GEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDG--EEWP 568 +G H ++I + + SL Y +A I FA +P G +WP Sbjct: 443 -PVLGTFHSNDIVFQDYLLGSGSLIYN-----------NAFIAFATDLDPNTAGLLVKWP 490 Query: 569 NFSKEDP 575 ++ Sbjct: 491 EYTSSSQ 497 >5THM-A nrPDB Length = 533 Score = 392 bits (1007), Expect = e-109, Method: Composition-based stats. Identities = 133/548 (24%), Positives = 228/548 (41%), Gaps = 88/548 (16%) Query: 37 CGVIDRLVVQTSSGPVRGRSVTVQGREVHVYTGIPYAKPPVEDLRFRKPVP-AEPWHGVL 95 D L+VQ G +RGR + Y IPYA+PP DLRF P P + W + Sbjct: 11 SDTDDPLLVQLPQGVLRGRD----NGSYYSYESIPYAEPPTGDLRFEAPEPYKQKWSDIF 66 Query: 96 DATGLSATCVQERYEYFPGFSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEH 155 DAT C+Q ++ PG + EDCL ++V+ P ++ Sbjct: 67 DATKTPVACLQW-DQFTPGANKLV-------GEEDCLTVSVYKPKNSK------------ 106 Query: 156 PNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVAS 215 N P++ I+GG FM G+A + + + G I+ Sbjct: 107 --------------------RNSFPVVAHIHGGAFMFGAAWQNGHEN--VMREGKFILVK 144 Query: 216 FQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGE 275 YR+G GFL S + PGN GL DQ LA++W+K N +FGG P+ + L G Sbjct: 145 ISYRLGPLGFL-------STGDRDLPGNYGLKDQRLALKWIKQNIASFGGEPQNVLLVGH 197 Query: 276 SAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASML 335 SAG +SV+ Q++ L K SG PW + + A E L C ++ Sbjct: 198 SAGGASVHLQMLREDFGQLAKAAFSFSGNALDPW--VIQKGARERAFELGRSVGCESA-- 253 Query: 336 KTNPAHVMSCMRSVDAKTIS--VQQWNSYSGILSFPSAPTID-----GAFLPADPMTLMK 388 + A + C++S A + V+++ +S + P +P ++ GAF+ DP ++K Sbjct: 254 -EDSASLKKCLKSKPASELVTAVRKFLIFSYVPFAPFSPVLEPSDAPGAFITQDPRDVIK 312 Query: 389 TADLKDYDILMGNVRDEGTY---FLLYDFIDYFDKDDATALPRDKYLEIMNN-IFGKATQ 444 + + V ++G Y LL + DD +++LE+ +F + T+ Sbjct: 313 SGKFGQVPWAVSYVTEDGGYNAALLLKERKSGVVIDDLN----ERWLELAPYLLFYRDTK 368 Query: 445 AEREAIIFQYT---SWEGNPGYQ--NQQQIGRAVGDHFFTCPTNEYAQALAERGASVHYY 499 +++ + + GN + + ++ R D F T E + G S Y Sbjct: 369 TKKDMDDYSRKIKQEYIGNQRFDIGSYSELQRLFTDILFKNGTQESLDLHRKYGKSPVYA 428 Query: 500 YFTHRTSTSLWGEWM--------GVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAV 551 Y + + + G +HGD+ F + + ++ RP E+ + + ++ + Sbjct: 429 YVYDNPAEKGIAQVLANRTDYDFGTVHGDDYSLIFENSVRD-VEMRPDEQIISRNFINML 487 Query: 552 IEFAKTGN 559 +FA + + Sbjct: 488 ADFASSDD 495 >1LLF-A nrPDB Length = 534 Score = 391 bits (1004), Expect = e-109, Method: Composition-based stats. Identities = 135/550 (24%), Positives = 211/550 (38%), Gaps = 112/550 (20%) Query: 65 HVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLSATCVQERYEY----------FPG 114 + GIP+A+PPV +LRF+ PVP T +C+Q+ E Sbjct: 21 EAFLGIPFAEPPVGNLRFKDPVPYSGSLNGQKFTSYGPSCMQQNPEGTFEENLGKTALDL 80 Query: 115 FSGEEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQN 174 +++ SEDCL INV P + Sbjct: 81 VMQSKVFQAVLPQSEDCLTINVVRPPGTK------------------------------- 109 Query: 175 TTNGLPILIWIYGGGFMTGSATLDIYNADIMAAV---GNVIVASFQYRVGAFGFLHLAPE 231 LP+++WI+GGGF GS T+ + +V +I + YRV ++GFL Sbjct: 110 AGANLPVMLWIFGGGFEIGSPTIFPPAQMVTKSVLMGKPIIHVAVNYRVASWGFLA---- 165 Query: 232 MPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLM---- 287 + E GN GL DQ L ++W+ DN FGG+P +T+FGESAGS SV L+ Sbjct: 166 -GDDIKAEGSGNAGLKDQRLGMQWVADNIAGFGGDPSKVTIFGESAGSMSVLCHLIWNDG 224 Query: 288 --SPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSC 345 + + L + G+MQSG M P + EI ++ C ++ K ++C Sbjct: 225 DNTYKGKPLFRAGIMQSGAM-VPSDPVDGTYGNEIYDLFVSSAGCGSASDK------LAC 277 Query: 346 MRSVDAKTISVQQWNSYSGILSFPS-----APTIDGAFLPADPMTLMKTADLKDYDILMG 400 +RS + T+ N+ G L++ S P DG + D L++ +++G Sbjct: 278 LRSASSDTLLDAT-NNTPGFLAYSSLRLSYLPRPDGKNITDDMYKLVRDGKYASVPVIIG 336 Query: 401 NVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYT----- 455 + DEGT F L + F A+ AE + ++ Y Sbjct: 337 DQNDEGTIFGLSSL---------NVTTNAQARAYFKQSFIHASDAEIDTLMAAYPQDITQ 387 Query: 456 SWEGNPGYQNQ-----QQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLW 510 + G N ++I +GD F Y + G Y F + + L Sbjct: 388 GSPFDTGIFNAITPQFKRISAVLGDLAFIH-ARRYFLNHFQGGTK---YSFLSKQLSGL- 442 Query: 511 GEWMGVLHGDEI---EYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDG--E 565 MG H ++I +Y G + S+ Y +A I FA +P G Sbjct: 443 -PIMGTFHANDIVWQDYLLG---SGSVIYN-----------NAFIAFATDLDPNTAGLLV 487 Query: 566 EWPNFSKEDP 575 WP ++ Sbjct: 488 NWPKYTSSSQ 497 >1GZ7-A nrPDB Length = 534 Score = 387 bits (994), Expect = e-108, Method: Composition-based stats. Identities = 142/550 (25%), Positives = 222/550 (40%), Gaps = 112/550 (20%) Query: 65 HVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLSATCVQER-----YEYFPGFSG-- 117 + GIP+A+PPV LRF+ PVP T +C+Q + P + Sbjct: 21 EKFLGIPFAEPPVGTLRFKPPVPYSASLNGQQFTSYGPSCMQMNPMGSFEDTLPKNALDL 80 Query: 118 ---EEIWNPNTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQN 174 +I+ EDCL INV P R Sbjct: 81 VLQSKIFQVVLPNDEDCLTINVIRPPGTR------------------------------- 109 Query: 175 TTNGLPILIWIYGGGFMTGSATLDIYNADIMAAV---GNVIVASFQYRVGAFGFLHLAPE 231 + GLP+++WI+GGGF G ++L + + +V VI S YRV ++GFL Sbjct: 110 ASAGLPVMLWIFGGGFELGGSSLFPGDQMVAKSVLMGKPVIHVSMNYRVASWGFLA---- 165 Query: 232 MPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLM---- 287 + E GN GL DQ LA++W+ DN FGG+P +T++GESAGS S L+ Sbjct: 166 -GPDIQNEGSGNAGLHDQRLAMQWVADNIAGFGGDPSKVTIYGESAGSMSTFVHLVWNDG 224 Query: 288 --SPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNASMLKTNPAHVMSC 345 + + L + +MQSG M P + EI ++ C ++ K ++C Sbjct: 225 DNTYNGKPLFRAAIMQSGCM-VPSDPVDGTYGTEIYNQVVASAGCGSASDK------LAC 277 Query: 346 MRSVDAKTISVQQWNSYSGILSFPS-----APTIDGAFLPADPMTLMKTADLKDYDILMG 400 +R + T+ Q + G+L++PS P DG F+ D L++ +++G Sbjct: 278 LRGLSQDTL-YQATSDTPGVLAYPSLRLSYLPRPDGTFITDDMYALVRDGKYAHVPVIIG 336 Query: 401 NVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAEREAIIFQYTS--WE 458 + DEGT F L + F A+ AE + ++ YTS + Sbjct: 337 DQNDEGTLFGLSSL---------NVTTDAQARAYFKQSFIHASDAEIDTLMAAYTSDITQ 387 Query: 459 GNP---GYQNQ-----QQIGRAVGDHFFTCPTNEYAQALAERGASVHYYYFTHRTSTSLW 510 G+P G N ++I +GD FT Y + G Y F + + L Sbjct: 388 GSPFDTGIFNAITPQFKRISALLGDLAFTL-ARRYFLNYYQGGTK---YSFLSKQLSGL- 442 Query: 511 GEWMGVLHGDEI---EYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAKTGNPAQDG--E 565 +G HG++I +Y G + S+ Y +A I FA +P + G Sbjct: 443 -PVLGTFHGNDIIWQDYLVG---SGSVIYN-----------NAFIAFANDLDPNKAGLWT 487 Query: 566 EWPNFSKEDP 575 WP ++ Sbjct: 488 NWPTYTSSSQ 497 >1THG-A nrPDB Length = 544 Score = 379 bits (974), Expect = e-105, Method: Composition-based stats. Identities = 135/574 (23%), Positives = 215/574 (37%), Gaps = 109/574 (18%) Query: 59 VQGREVHVYTGIPYAKPPVEDLRFRKPVPAEPWHGVLDATGLSATCVQ----------ER 108 V +V + GIP+A PP+ DLRF+ P P + L A S C+Q ++ Sbjct: 16 VLEGKVDTFKGIPFADPPLNDLRFKHPQPFTGSYQGLKANDFSPACMQLDPGNSLTLLDK 75 Query: 109 YEYFPGFSGEEIWNP-------NTNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQA 161 EE P +++EDCLY+NV+ PA + Sbjct: 76 ALGLAKVIPEEFRGPLYDMAKGTVSMNEDCLYLNVFRPAGTK------------------ 117 Query: 162 DTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVG---NVIVASFQY 218 LP+++WIYGG F+ GS+ N+ + ++ V+ S Y Sbjct: 118 -------------PDAKLPVMVWIYGGAFVYGSSAAYPGNSYVKESINMGQPVVFVSINY 164 Query: 219 RVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAG 278 R G FGFL E N GL DQ + W+ DN FGG+P+ + +FGESAG Sbjct: 165 RTGPFGFLG-----GDAITAEGNTNAGLHDQRKGLEWVSDNIANFGGDPDKVMIFGESAG 219 Query: 279 SSSVNAQLM------SPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCNCNA 332 + SV QL+ + + L ++QSG P+ +S C+ Sbjct: 220 AMSVAHQLIAYGGDNTYNGKKLFHSAILQSGGPL-PYHDSSSVGPDISYNRFAQYAGCDT 278 Query: 333 SMLKTNPAHVMSCMRSVDAKTISVQQ----WNSYSGILS--FPSAPTIDGAFLPADPMTL 386 S + + C+RS + + Q G+L P DG +P L Sbjct: 279 SASANDT---LECLRSKSSSVLHDAQNSYDLKDLFGLLPQFLGFGPRPDGNIIPDAAYEL 335 Query: 387 MKTADLKDYDILMGNVRDEGTYFLLYDFIDYFDKDDATALPRDKYLEIMNNIFGKATQAE 446 ++ + GN DEGT F +AT P K + + IF A++A Sbjct: 336 FRSGRYAKVPYISGNQEDEGTAFAPVAL-------NATTTPHVK--KWLQYIFYDASEAS 386 Query: 447 REAIIFQY--TSWEGNP---GYQNQ-----QQIGRAVGDHFFTCPTNEYAQALAERGASV 496 + ++ Y T G+P G N +++ + D F P A + + Sbjct: 387 IDRVLSLYPQTLSVGSPFRTGILNALTPQFKRVAAILSDMLFQSP--RRVMLSATKDVNR 444 Query: 497 HYYYFTHRTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERELGKRMLSAVIEFAK 556 Y TH + ++G HG+E+ + F + + Y L I FA Sbjct: 445 WTYLSTHLHNLV---PFLGTFHGNELIFQFNVNIGPANSY-----------LRYFISFAN 490 Query: 557 TGNPA--QDGEEWPNFSKEDPVYYIFSTDDKIEK 588 +P + +W ++ E D + + Sbjct: 491 HHDPNVGTNLLQWDQYTDEGKEMLEIHMTDNVMR 524 >4WY5-A nrPDB Length = 332 Score = 106 bits (264), Expect = 3e-23, Method: Composition-based stats. Identities = 33/143 (23%), Positives = 55/143 (38%), Gaps = 16/143 (11%) Query: 152 GGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNV 211 + T L P LP+LI+++GGGF+ GS I + NV Sbjct: 53 EEDKVVESDGKTLKLTIVRPPGTEDQILPVLIFLHGGGFVFGSKYTHIKPVRDLTVKANV 112 Query: 212 IVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMT 271 + Y + EA + + AI W+++NA + N E + Sbjct: 113 VTVFVDYSLSP----------------EAKFPTAIEEIYAAILWVRENASSLNINAEALA 156 Query: 272 LFGESAGSSSVNAQLMSPVTRGL 294 + G+SAG++ A + +GL Sbjct: 157 VAGDSAGATLSAAVSIYAKEKGL 179 >2C7B-A nrPDB Length = 311 Score = 104 bits (258), Expect = 2e-22, Method: Composition-based stats. Identities = 30/130 (23%), Positives = 57/130 (43%), Gaps = 18/130 (13%) Query: 173 QNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEM 232 GLP +++ +GGGF+ GS + ++ + + +V S YR+ Sbjct: 67 PKKAAGLPAVLYYHGGGFVFGSIETHDHICRRLSRLSDSVVVSVDYRLAP---------- 116 Query: 233 PSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGS--SSVNAQLMSPV 290 E + D A++W+ D A G +P+ + + G+SAG ++V + L Sbjct: 117 ------EYKFPTAVEDAYAALKWVADRADELGVDPDRIAVAGDSAGGNLAAVVSILDRNS 170 Query: 291 TRGLVKRGMM 300 LVK+ ++ Sbjct: 171 GEKLVKKQVL 180 >2YH2-A nrPDB Length = 313 Score = 93.8 bits (231), Expect = 2e-19, Method: Composition-based stats. Identities = 31/204 (15%), Positives = 68/204 (33%), Gaps = 29/204 (14%) Query: 173 QNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEM 232 LP +++ +GGGF+ GS + +A + +V S YR+ Sbjct: 70 PRDGERLPAVVYYHGGGFVLGSVETHDHVCRRLANLSGAVVVSVDYRLAP---------- 119 Query: 233 PSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTR 292 E + D A +W+ DN G + + + G+SAG + + R Sbjct: 120 ------EHKFPAAVEDAYDAAKWVADNYDKLGVDNGKIAVAGDSAGGNLAAVTAIMARDR 173 Query: 293 G--------LVKRGMMQSGTMNAPWSHMTSEKAVEIGKALINDCN-----CNASMLKTNP 339 G L+ + +G+ + + V + L+ L Sbjct: 174 GESFVKYQVLIYPAVNLTGSPTVSRVEYSGPEYVILTADLMAWFGRQYFSKPQDALSPYA 233 Query: 340 AHVMSCMRSVDAKTISVQQWNSYS 363 + + + + ++ + +++ Sbjct: 234 SPIFADLSNLPPALVITAEYDPLR 257 >2O7R-A nrPDB Length = 338 Score = 84.9 bits (208), Expect = 9e-17, Method: Composition-based stats. Identities = 38/177 (21%), Positives = 63/177 (35%), Gaps = 43/177 (24%) Query: 140 AKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDI 199 + N L + + LP++++ +GGGF+ SA I Sbjct: 44 SPDPTSSSPVLTKDLALNPLHNTFVRLFLPRHALYNSAKLPLVVYFHGGGFILFSAASTI 103 Query: 200 YNADI--MAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLK 257 ++ MA V++AS YR+ E D A++W+K Sbjct: 104 FHDFCCEMAVHAGVVIASVDYRLAP----------------EHRLPAAYDDAMEALQWIK 147 Query: 258 DNAHAFGGNPEWMTLF---------GESAG----------SSSVNAQLMSPVTRGLV 295 D+ EW+T F GESAG +++V +L+ +GLV Sbjct: 148 DS------RDEWLTNFADFSNCFIMGESAGGNIAYHAGLRAAAVADELLPLKIKGLV 198 >6AAE-A nrPDB Length = 317 Score = 72.6 bits (176), Expect = 5e-13, Method: Composition-based stats. Identities = 25/131 (19%), Positives = 45/131 (34%), Gaps = 16/131 (12%) Query: 163 TDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGA 222 D P++ ++++ +GGG++ G+ +A V S YR+ Sbjct: 56 RDLDARLYVPEDADERPALMVYYHGGGWVIGTLDTHDGTCRALAQKSGCAVLSIAYRLAP 115 Query: 223 FGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSV 282 E D A+ W K NA G + + + + G+SAG + Sbjct: 116 ----------------EYRYPAPAEDCYDALVWAKQNAATLGVDGDRLAVGGDSAGGNLA 159 Query: 283 NAQLMSPVTRG 293 A + R Sbjct: 160 AAVAIMARDRN 170 >4WY8-A nrPDB Length = 327 Score = 71.0 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 25/140 (17%), Positives = 44/140 (31%), Gaps = 18/140 (12%) Query: 157 NGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASF 216 N K L LP +++ +GGG++ GS + V Sbjct: 59 NRKNGSKIELTITRPLDTENQVLPPIVFFHGGGWVVGSKLTHRRTVYELTVRARAAVIFV 118 Query: 217 QYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLK--DNAHAFGGNPEWMTLFG 274 Y + E L + A+ W+ +NA + +P + + G Sbjct: 119 NYSLSP----------------EVRFPTALEECLDAVVWVAKEENAKSINVDPTKLVVAG 162 Query: 275 ESAGSSSVNAQLMSPVTRGL 294 +SAG + + GL Sbjct: 163 DSAGGNLSAVVCIRAKQLGL 182 >5L2P-A nrPDB Length = 306 Score = 71.0 bits (172), Expect = 2e-12, Method: Composition-based stats. Identities = 32/136 (23%), Positives = 52/136 (38%), Gaps = 17/136 (12%) Query: 159 KQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQY 218 K D + I +P TN ++ +GG ++ GS + + I++ V S Y Sbjct: 56 KLEDYELPIRIYSPIKRTNNGLVM-HFHGGAWILGSIETEDAISRILSNSCECTVISVDY 114 Query: 219 RVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAG 278 R+ E ++D AI W +DNA G + + + FG SAG Sbjct: 115 RLAP----------------EYKFPTAVYDCFNAIVWARDNAGELGIDKDKIATFGISAG 158 Query: 279 SSSVNAQLMSPVTRGL 294 + V A + L Sbjct: 159 GNLVAATSLLARDNKL 174 >3AIM-A nrPDB Length = 323 Score = 68.3 bits (165), Expect = 1e-11, Method: Composition-based stats. Identities = 23/148 (15%), Positives = 45/148 (30%), Gaps = 17/148 (11%) Query: 147 GRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMA 206 R G ++ T +L++ +GGGF+ G + Sbjct: 58 PREEVGKIEDITIPGSETNIKARVYYPKTQGPYGVLVYYHGGGFVLGDIESYDPLCRAIT 117 Query: 207 AVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGN 266 + S YR+ E + D A++W+ +N+ F G Sbjct: 118 NSCQCVTISVDYRLAP----------------ENKFPAAVVDSFDALKWVYNNSEKFNGK 161 Query: 267 PEWMTLFGESAGSSSVNAQLMSPVTRGL 294 + + G+SAG + + + Sbjct: 162 YG-IAVGGDSAGGNLAAVTAILSKKENI 188 >4V2I-A nrPDB Length = 323 Score = 67.6 bits (163), Expect = 2e-11, Method: Composition-based stats. Identities = 19/123 (15%), Positives = 43/123 (34%), Gaps = 16/123 (13%) Query: 171 NPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAP 230 PQ T+ LP++++ +G G++ G ++ N + Y Sbjct: 69 RPQGNTDRLPVIVYFHGAGWVMGDTGTHDRLVRELSVRANAALVFVDYERSP-------- 120 Query: 231 EMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPV 290 EA V + +++ +++ +P + + G+S G + + Sbjct: 121 --------EARYPVAIEQDYAVTKYVAEHSEQLNVDPTRLAIAGDSVGGNMTAVVSLLAQ 172 Query: 291 TRG 293 RG Sbjct: 173 ERG 175 >3EBL-A nrPDB Length = 365 Score = 64.9 bits (156), Expect = 1e-10, Method: Composition-based stats. Identities = 31/158 (19%), Positives = 56/158 (35%), Gaps = 20/158 (12%) Query: 141 KARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIY 200 +R R A G+ G A T ++ P++I+ +GG F+ SA+ IY Sbjct: 74 GLEVRIYRAAAEGDAEEGAAAVTRPILEFLTDAPAAEPFPVIIFFHGGSFVHSSASSTIY 133 Query: 201 N--ADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWL-K 257 + + +V S YR E D A++W+ Sbjct: 134 DSLCRRFVKLSKGVVVSVNYRRAP----------------EHRYPCAYDDGWTALKWVMS 177 Query: 258 DNAHAFGGNPE-WMTLFGESAGSSSVNAQLMSPVTRGL 294 GG+ + + L G+S+G + + + G+ Sbjct: 178 QPFMRSGGDAQARVFLSGDSSGGNIAHHVAVRAADEGV 215 >5AOA-A nrPDB Length = 286 Score = 62.6 bits (150), Expect = 5e-10, Method: Composition-based stats. Identities = 32/142 (22%), Positives = 55/142 (38%), Gaps = 15/142 (10%) Query: 149 GANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAV 208 GA + D I+ + +++ +GGG+ +GS + A Sbjct: 14 GAEVKVYKKVDNVDLKLYIYKPADWKPADRRSAIVFFFGGGWQSGSPAQFRPQCEYFAGR 73 Query: 209 GNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPE 268 G V +A+ YRVG+ + +A + D AIRW++ +A G +P+ Sbjct: 74 GMVAMAA-DYRVGSRHNVKVADCVA--------------DAKSAIRWVRQHAAELGVDPQ 118 Query: 269 WMTLFGESAGSSSVNAQLMSPV 290 + G SAG +M P Sbjct: 119 KIVASGGSAGGHLAACTVMVPD 140 >3WJ2-A nrPDB Length = 308 Score = 61.0 bits (146), Expect = 2e-09, Method: Composition-based stats. Identities = 22/124 (17%), Positives = 42/124 (33%), Gaps = 17/124 (13%) Query: 164 DHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAF 223 D N + N +++ +GGGF+ G+ +A V + S +YR+ Sbjct: 61 DGRTLNARMYDDNNAKSAILYYHGGGFLFGNIETYDNYCRFLAKESGVKIISIEYRLAP- 119 Query: 224 GFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVN 283 E D + ++ FG + + G+SAG++ Sbjct: 120 ---------------EHKFPDAFNDAYDSFHYIAKKKKDFGIE-GRIGVAGDSAGANLAA 163 Query: 284 AQLM 287 A + Sbjct: 164 ALCL 167 >2ZSH-A nrPDB Length = 351 Score = 57.9 bits (138), Expect = 1e-08, Method: Composition-based stats. Identities = 24/144 (16%), Positives = 49/144 (34%), Gaps = 20/144 (13%) Query: 155 HPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYN--ADIMAAVGNVI 212 P + I + + +P++++ +GG F SA IY+ + + + Sbjct: 89 RPAYADQEQPPSILDLEKPVDGDIVPVILFFHGGSFAHSSANSAIYDTLCRRLVGLCKCV 148 Query: 213 VASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTL 272 V S YR E P D +A+ W+ + + + Sbjct: 149 VVSVNYRRAP----------------ENPYPCAYDDGWIALNWVNSRSWLKSKKDSKVHI 192 Query: 273 F--GESAGSSSVNAQLMSPVTRGL 294 F G+S+G + + + G+ Sbjct: 193 FLAGDSSGGNIAHNVALRAGESGI 216 >4KRY-A nrPDB Length = 333 Score = 51.0 bits (120), Expect = 1e-06, Method: Composition-based stats. Identities = 19/113 (16%), Positives = 38/113 (33%), Gaps = 16/113 (14%) Query: 182 LIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAP 241 L +++GGGF+ G+ ++A+ V Y + EA Sbjct: 101 LFYLHGGGFILGNLDTHDRIMRLLASYSQCTVIGIDYTLSP----------------EAR 144 Query: 242 GNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGL 294 + + A + A + N + G+SAG+ A + + + Sbjct: 145 FPQAIEEIVAACCYFHQQAEDYQINMSRIGFAGDSAGAMLALASALWLRDKQI 197 >3GA7-A nrPDB Length = 326 Score = 47.5 bits (111), Expect = 2e-05, Method: Composition-based stats. Identities = 18/111 (16%), Positives = 37/111 (33%), Gaps = 16/111 (14%) Query: 182 LIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAP 241 L +++GGGF+ G+ ++A V Y + +A Sbjct: 90 LYYLHGGGFILGNLDTHDRIMRLLARYTGCTVIGIDYSLSP----------------QAR 133 Query: 242 GNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTR 292 + + + +A + N E + G+SAG+ A + + Sbjct: 134 YPQAIEETVAVCSYFSQHADEYSLNVEKIGFAGDSAGAMLALASALWLRDK 184 >4Q3K-A nrPDB Length = 260 Score = 43.3 bits (100), Expect = 3e-04, Method: Composition-based stats. Identities = 28/100 (28%), Positives = 37/100 (37%), Gaps = 17/100 (17%) Query: 180 PILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEE 239 P ++ GGG+ S A A G +Y V E Sbjct: 55 PAMLIFPGGGYQFCSDREAEPIALSYLAKGYNAFV-LRYSV----------------KEH 97 Query: 240 APGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGS 279 A L D A+ +LKDNAHA NP+ + + G SAG Sbjct: 98 AVFPRPLIDAEDALSYLKDNAHALHINPDKIAVIGFSAGG 137 >3O4I-A nrPDB Length = 582 Score = 42.1 bits (97), Expect = 7e-04, Method: Composition-based stats. Identities = 39/218 (17%), Positives = 70/218 (32%), Gaps = 22/218 (10%) Query: 139 PAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLD 198 P R +++ +G P ++ ++GG F S + D Sbjct: 323 PEDLRRSIAGSRLVWVESFDGSRVPTYVLESGRAPTPG---PTVVLVHGGPFAEDSDSWD 379 Query: 199 IYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKD 258 + A + AA V YR G+ G+ + P L D + A RW ++ Sbjct: 380 TFAASLAAA--GFHVVMPNYR-GSTGY-GEEWRLKIIGD---PCGGELEDVSAAARWARE 432 Query: 259 NAHAFGGNPEWMTLFGESAGS-SSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKA 317 + G + + G S G ++ A M P GL K G+ G W M Sbjct: 433 S-----GLASELYIMGYSYGGYMTLCALTMKP---GLFKAGVA--GASVVDWEEMYELSD 482 Query: 318 VEIGKALINDCNCNASMLKTNPAHVMSCMRSVDAKTIS 355 + I + + + + + R + + Sbjct: 483 AA-FRNFIEQLTGGSREIMRSRSPINHVDRIKEPLALI 519 >4BZW-A nrPDB Length = 282 Score = 39.1 bits (89), Expect = 0.006, Method: Composition-based stats. Identities = 26/110 (23%), Positives = 37/110 (33%), Gaps = 15/110 (13%) Query: 174 NTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMP 233 T PI+I GGGF S + A M A G V Y++ Sbjct: 29 ETAVDYPIMIICPGGGFTYHSGREEAPIATRMMAAGMHTVV-LNYQL------------- 74 Query: 234 SEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVN 283 +++ L I W+ A A + + + L G SAG V Sbjct: 75 -IVGDQSVYPWALQQLGATIDWITTQASAHHVDCQRIILAGFSAGGHVVA 123 >5YP1-A nrPDB Length = 745 Score = 38.7 bits (88), Expect = 0.007, Method: Composition-based stats. Identities = 31/186 (16%), Positives = 51/186 (27%), Gaps = 18/186 (9%) Query: 140 AKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTG-----S 194 AK R H A G + + + P+++++YGG Sbjct: 481 AKYRAAHQPTAYGTLTAADGTTPLHYSLIKPAGFDPKKQYPVVVFVYGGPAAQTVTRAWP 540 Query: 195 ATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIR 254 D + +A G V+ G + E + DQ I Sbjct: 541 GRSDSFFNQYLAQQGYVVFTLDNRGTPRRGAAFGGALYGKQGTVE------VDDQLRGIE 594 Query: 255 WLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVKRGMMQSGTMNAPWSHMTS 314 WLK AF +P + ++G S G L +G W+ + Sbjct: 595 WLKS--QAF-VDPARIGVYGWSNGGYMTLMLLAKHDEA----YACGVAGAPVTDWALYDT 647 Query: 315 EKAVEI 320 Sbjct: 648 HYTERY 653 >3FCX-A nrPDB Length = 282 Score = 35.2 bits (79), Expect = 0.096, Method: Composition-based stats. Identities = 38/265 (14%), Positives = 75/265 (28%), Gaps = 54/265 (20%) Query: 172 PQNTTNGLPILIWIYG-----GGFMTGSATLDIYNADIMAAVGNVIVA--------SFQY 218 P+ T P L W+ G F++ S + G V++A + + Sbjct: 38 PKAETGKCPALYWLSGLTCTEQNFISKSGY-----HQSASEHGLVVIAPDTSPRGCNIKG 92 Query: 219 RVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNA-----HAFGGNPEWMTLF 273 ++ F A + N ++ ++ + F +P+ M++F Sbjct: 93 EDESWDFGTGAGFYVDATEDPWKTNYRMY------SYVTEELPQLINANFPVDPQRMSIF 146 Query: 274 GESAGSSSVNAQLMSPVTRGLVKRGMMQSGTM-NAPWSHMTSEKAVEIGKALINDCNCNA 332 G S G + + PW KA + Sbjct: 147 GHSMGGHGALICALKNPGKYKSVSAFAPICNPVLCPWGK----------KAFSGYLGTDQ 196 Query: 333 SMLKT-NPAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPADPMTLMKTAD 391 S K + H++ + Q + +DG LP + Sbjct: 197 SKWKAYDATHLVKSYPGSQLDILIDQGKDDQF---------LLDGQLLPD---NFIAACT 244 Query: 392 LKDYDILMGNVRD-EGTYFLLYDFI 415 K ++ D + +Y+ + FI Sbjct: 245 EKKIPVVFRLQEDYDHSYYFIATFI 269 >4E11-A nrPDB Length = 303 Score = 34.4 bits (77), Expect = 0.18, Method: Composition-based stats. Identities = 32/194 (16%), Positives = 59/194 (30%), Gaps = 27/194 (13%) Query: 100 LSATCVQERYEYFPGFSGEEIWN---PNTNVSEDCLYINVWAPAKARLRHGRGANGGEHP 156 + C +YFP + + PN V E + K R G Sbjct: 5 YNPRCKDLDRDYFPSYHTTRFQDQPEPNLAVLE-----HFVRVTKQHGRELTEKQGITVD 59 Query: 157 NGKQADTDHLIHNGNPQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVIVASF 216 + + + L+ + TTN P+ ++++GG + ++ + G + Sbjct: 60 HLRYGEGRQLVDVFYSEKTTNQAPLFVFVHGGYWQEMDMSMSCSIVGPLVRRGYRVAV-M 118 Query: 217 QYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGES 276 Y + L + F + W+ D +T G S Sbjct: 119 DYNLCPQVTLEQLMTQFTHF----------------LNWIFDYTEMTKV--SSLTFAGHS 160 Query: 277 AGSSSVNAQLMSPV 290 AG+ + LM P Sbjct: 161 AGAHLLAQILMRPN 174 >3T5Y-A nrPDB Length = 357 Score = 33.3 bits (74), Expect = 0.32, Method: Composition-based stats. Identities = 19/61 (31%), Positives = 26/61 (42%), Gaps = 2/61 (3%) Query: 226 LHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQ 285 L L E S G+VG DQ + L +NA G+ + LFG AG + A Sbjct: 278 LGLPDERTSWAYGRTTGHVGAGDQYAGLAHLVENALVQPGD--RVLLFGGGAGYTCTAAV 335 Query: 286 L 286 + Sbjct: 336 V 336 >4Q1V-A nrPDB Length = 710 Score = 32.9 bits (73), Expect = 0.47, Method: Composition-based stats. Identities = 29/156 (18%), Positives = 51/156 (32%), Gaps = 27/156 (17%) Query: 174 NTTNGLPILIWIYG--------GGFMTGSATLDIYNADIMAAVGNVIVASFQYRVGA-FG 224 + P+++++YG GG+ G+ D Y MA+ G I+ + R + G Sbjct: 484 DPAKKYPVIVYVYGGPHAQCVTGGWQNGARGWDTY----MASKG-YIMFTIDNRGSSNRG 538 Query: 225 FLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNA 284 EE DQ + +LK + E + + G S G A Sbjct: 539 LTFENATFRRLGIEEGK------DQVKGVEFLK---SLPYVDSERIGVHGWSFGGHMTTA 589 Query: 285 QLMSPVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEI 320 ++ + K G+ G W + Sbjct: 590 LMLRYPE--IFKVGVA--GGPVIDWGYYEIMYGERY 621 >5X6S-A nrPDB Length = 275 Score = 32.1 bits (71), Expect = 0.86, Method: Composition-based stats. Identities = 22/138 (15%), Positives = 41/138 (29%), Gaps = 19/138 (13%) Query: 172 PQNTTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGN----VIVASFQYRVGAFGFLH 227 P N + I++ I+ + TG+ ++ VI S Y G + Sbjct: 24 PNNLASNPGIVVAIH---YCTGTGPGYYGDSPYATLSEQYGFIVIYPSSPYSGGCW---- 76 Query: 228 LAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLM 287 + GN + W +G + + + G S+G+ N Sbjct: 77 -DVSSQATLTHNGGGNSNSIANM--VTWT---ISKYGADSSKVFVTGSSSGAMMTNVMAA 130 Query: 288 SPVTRGLVKRGMMQSGTM 305 + L + SG Sbjct: 131 TYPE--LFAAATVYSGVS 146 >2ECF-A nrPDB Length = 741 Score = 31.4 bits (69), Expect = 1.4, Method: Composition-based stats. Identities = 23/159 (14%), Positives = 41/159 (25%), Gaps = 18/159 (11%) Query: 174 NTTNGLPILIWIYGGGFMTGSATLDIYNADIM----AAVGNVIVASFQYRVGA-FGFLHL 228 + P+ +++YGG D + A +V S R G Sbjct: 512 DPAKRYPVAVYVYGGPASQTVTDSWPGRGDHLFNQYLAQQGYVVFSLDNRGTPRRGRDFG 571 Query: 229 APEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMS 288 + E + DQ + WLK +P + + G S G + Sbjct: 572 GALYGKQGTVE------VADQLRGVAWLKQQPW---VDPARIGVQGWSNGG----YMTLM 618 Query: 289 PVTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKALIND 327 + + +G W S + Sbjct: 619 LLAKASDSYACGVAGAPVTDWGLYDSHYTERYMDLPARN 657 >2AE2-A nrPDB Length = 260 Score = 30.6 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 27/163 (16%), Positives = 47/163 (28%), Gaps = 10/163 (6%) Query: 117 GEEIWNPNTNVSE--DCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQN 174 G ++ + N E DCL W ++ + +T +G Sbjct: 33 GASVYTCSRNQKELNDCLTQ--WRSKGFKVEASVCDLSSRSERQELMNTVANHFHGKLNI 90 Query: 175 TTNGLPILIWIYGGGFMTGSATLDIYNADIMAAVGNVI---VASFQYRVGAFGFLHLAPE 231 N I+I+ + +L + A +V+ R ++ Sbjct: 91 LVNNAGIVIYKEAKDYTVEDYSLIMSINFEAAYHLSVLAHPFLKASERGNVVFISSVSGA 150 Query: 232 MPSEFAEEAPGNVGLWDQA---LAIRWLKDNAHAFGGNPEWMT 271 + + G DQ LA W KDN G P + Sbjct: 151 LAVPYEAVYGATKGAMDQLTRCLAFEWAKDNIRVNGVGPGVIA 193 >1VBH-A nrPDB Length = 876 Score = 30.6 bits (67), Expect = 2.1, Method: Composition-based stats. Identities = 11/60 (18%), Positives = 22/60 (36%), Gaps = 1/60 (1%) Query: 222 AFGFLHLAPEMPSEFAEEAPGNVGLW-DQALAIRWLKDNAHAFGGNPEWMTLFGESAGSS 280 GF GLW + ++W+++ A G+P+ L +G++ Sbjct: 42 PPGFTVSTEACQQYQDAGCALPAGLWAEIVDGLQWVEEYMGATLGDPQRPLLLSVRSGAA 101 >2EEP-A nrPDB Length = 706 Score = 30.2 bits (66), Expect = 3.0, Method: Composition-based stats. Identities = 23/154 (14%), Positives = 46/154 (29%), Gaps = 17/154 (11%) Query: 174 NTTNGLPILIWIYGG---GFMTGSATLDIYNADIMAAVGNVIVASFQYRVGA-FGFLHLA 229 + P+++++YGG +T + + DI A V + R A G Sbjct: 480 DPAKKYPVIVYVYGGPHAQLVTKTWRSSVGGWDIYMAQKGYAVFTVDSRGSANRGAAFEQ 539 Query: 230 PEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSP 289 E + D + W+ + + + + G S G +++ Sbjct: 540 VIHRRLGQTEMADQMCGVDFLKSQSWV---------DADRIGVHGWSYGGFMTTNLMLTH 590 Query: 290 VTRGLVKRGMMQSGTMNAPWSHMTSEKAVEIGKA 323 + K G+ G W+ A Sbjct: 591 G--DVFKVGVA--GGPVIDWNRYEIMYGERYFDA 620 >4HXF-B nrPDB Length = 622 Score = 29.0 bits (63), Expect = 6.3, Method: Composition-based stats. Identities = 25/127 (19%), Positives = 45/127 (35%), Gaps = 18/127 (14%) Query: 180 PILIWIYGG--GFMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFA 237 P++++++GG G Y +MA+ G I R + +FA Sbjct: 379 PVIVFVHGGPKGMY---GYYFKYEMQLMASKGYYI-VYVNPR--------GSNGYSEDFA 426 Query: 238 EEAPGNVGLWDQALAIRWLKDNAH-AFGGNPEWMTLFGESAGSSSVNAQLMSPVTRGLVK 296 GL D + +++ + E + + G S G N L L K Sbjct: 427 LRVLERTGLEDFQDILNGIEEFLRLEPQADRERIGITGISYGGYMTNWAL---TQSDLFK 483 Query: 297 RGMMQSG 303 G+ ++G Sbjct: 484 AGISENG 490 >2BRG-A nrPDB Length = 297 Score = 29.0 bits (63), Expect = 6.8, Method: Composition-based stats. Identities = 16/109 (14%), Positives = 29/109 (26%), Gaps = 7/109 (6%) Query: 70 IPYAKPPVEDLRFRKPVPAEPWHGVLDATGLSATCVQERYEYFPGFSGEEIWNPNTNVSE 129 +PY P + R P + W + T P + ++ E Sbjct: 171 LPYVAPELLKRREFHAEPVDVWSCGIVLTA-------MLAGELPWDQPSDSCQEYSDWKE 223 Query: 130 DCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNG 178 Y+N W + E+P+ + D + G Sbjct: 224 KKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKDRWYNKPLKKG 272 >4V2P-A nrPDB Length = 351 Score = 28.7 bits (62), Expect = 9.3, Method: Composition-based stats. Identities = 17/83 (20%), Positives = 29/83 (34%), Gaps = 5/83 (6%) Query: 219 RVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIRWLKDNAHAFGGN---PEWMTLFGE 275 R G A + A E N + I + + + + PE TLFG+ Sbjct: 125 RSGTPAITVNASCLSFFVALEVASNYLNMRRYRRILVVSADIASVSLDFRKPENFTLFGD 184 Query: 276 SAGSSSVNAQLMSPVTRGLVKRG 298 +A ++ V L P + + Sbjct: 185 AAAAAVVT--LPEPGEKSCIHAS 205 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.119 0.337 Lambda K H 0.267 0.0366 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 24,359,872 Number of Sequences: 36641 Number of extensions: 990533 Number of successful extensions: 3004 Number of sequences better than 10.0: 58 Number of HSP's better than 10.0 without gapping: 75 Number of HSP's successfully gapped in prelim test: 28 Number of HSP's that attempted gapping in prelim test: 2537 Number of HSP's gapped (non-prelim): 132 length of query: 649 length of database: 10,336,785 effective HSP length: 103 effective length of query: 546 effective length of database: 6,562,762 effective search space: 3583268052 effective search space used: 3583268052 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.4 bits) S2: 62 (28.7 bits)