BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P07093 (398 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 4DY0-A nrPDB 778 0.0 1C5G-A nrPDB 304 4e-83 3LW2-A nrPDB 282 2e-76 4KDS-A nrPDB 274 4e-74 4DTE-A nrPDB 270 7e-73 6EE5-A nrPDB 223 2e-58 3F02-A nrPDB 212 2e-55 1BY7-A nrPDB 184 4e-47 1JJO-C nrPDB 184 9e-47 4EB1-I nrPDB 180 1e-45 3NDA-A nrPDB 177 7e-45 4P0F-A nrPDB 176 2e-44 4GA7-A nrPDB 176 2e-44 1ATT-A nrPDB 174 5e-44 5NCS-A nrPDB 166 2e-41 1UHG-A nrPDB 164 7e-41 4ZK0-A nrPDB 163 1e-40 4AJT-A nrPDB 158 4e-39 6CJ7-A nrPDB 157 1e-38 1K9O-I nrPDB 155 2e-38 2VDY-A nrPDB 154 7e-38 1SEK-A nrPDB 154 7e-38 2H4Q-A nrPDB 151 5e-37 2OL2-A nrPDB 151 6e-37 5INW-A nrPDB 146 2e-35 1JMJ-A nrPDB 146 2e-35 2H4P-A nrPDB 143 1e-34 1HLE-A nrPDB 142 3e-34 5HGC-A nrPDB 141 6e-34 1YXA-A nrPDB 141 6e-34 6HGE-B nrPDB 138 4e-33 5NCU-A nrPDB 137 6e-33 1XQJ-A nrPDB 137 1e-32 3PZF-A nrPDB 136 2e-32 3STO-A nrPDB 135 4e-32 3OZQ-A nrPDB 134 7e-32 4Y40-A nrPDB 130 7e-31 3DY0-A nrPDB 129 2e-30 3ZHA-A nrPDB 128 4e-30 4AJU-A nrPDB 126 2e-29 6BJ5-B nrPDB 125 3e-29 2V95-A nrPDB 123 1e-28 3LE2-A nrPDB 121 5e-28 2R9Y-A nrPDB 117 1e-26 3NE4-A nrPDB 115 3e-26 1C8O-A nrPDB 107 1e-23 2PEF-A nrPDB 105 4e-23 6F02-A nrPDB 102 4e-22 2XN5-A nrPDB 101 7e-22 1IMV-A nrPDB 100 2e-21 6F4U-A nrPDB 91 7e-19 1QMB-A nrPDB 90 1e-18 1M93-B nrPDB 79 3e-15 1SNG-A nrPDB 79 4e-15 2OAY-A nrPDB 69 3e-12 1MTP-A nrPDB 64 9e-11 5C98-A nrPDB 58 6e-09 5M3Y-A nrPDB 50 1e-06 2WXZ-C nrPDB 48 9e-06 2WXX-A nrPDB 40 0.002 3L0D-A nrPDB 31 1.1 2KKH-A nrPDB 30 2.1 3DOC-A nrPDB 29 3.2 4WVM-B nrPDB 28 4.9 2W5S-A nrPDB 28 6.1 4N9N-A nrPDB 28 6.8 1KV9-A nrPDB 28 7.8 >4DY0-A nrPDB Length = 379 Score = 778 bits (2009), Expect = 0.0, Method: Compositional matrix adjust. Identities = 379/379 (100%), Positives = 379/379 (100%) Query: 20 SHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAM 79 SHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAM Sbjct: 1 SHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAM 60 Query: 80 VMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVR 139 VMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVR Sbjct: 61 VMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVR 120 Query: 140 NVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQP 199 NVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQP Sbjct: 121 NVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQP 180 Query: 200 ENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPT 259 ENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPT Sbjct: 181 ENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPT 240 Query: 260 ESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDS 319 ESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDS Sbjct: 241 ESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDS 300 Query: 320 SKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLF 379 SKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLF Sbjct: 301 SKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLF 360 Query: 380 FIRHNPTGAVLFMGQINKP 398 FIRHNPTGAVLFMGQINKP Sbjct: 361 FIRHNPTGAVLFMGQINKP 379 >1C5G-A nrPDB Length = 402 Score = 304 bits (779), Expect = 4e-83, Method: Compositional matrix adjust. Identities = 157/380 (41%), Positives = 234/380 (61%), Gaps = 4/380 (1%) Query: 21 HFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMV 80 H P + L S+ G++VF Q+ ++ N+V SP+G+ASVL MLQL G T++Q+ Sbjct: 25 HHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAA 84 Query: 81 MRYGVN--GVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEV 138 M + ++ G+ L+ + K ++ NKD ++ +A+FV+ ++ F+ +F+ V Sbjct: 85 MGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTV 144 Query: 139 RNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQ 198 + V+F + A IN WVK T+ MI NLL +D LTRLVLVNA+YF G WK+ F Sbjct: 145 KQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQ-LTRLVLVNALYFNGQWKTPFP 203 Query: 199 PENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALP 258 +T +R F +DG + VPM+AQ + F + P+ +Y+ +ELPYHG+++SM IA P Sbjct: 204 DSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAP 263 Query: 259 TESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFD 318 E PLSA+ +S + I W M ++LPKF+ + DL++PL+ LG+TDMF Sbjct: 264 YEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFR 323 Query: 319 SSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFL 378 +A+F + + E LHV+ LQK KIEV+E GT AS++T I+ AR +P I+DRPFL Sbjct: 324 QFQADFTSL-SDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFL 382 Query: 379 FFIRHNPTGAVLFMGQINKP 398 F +RHNPTG VLFMGQ+ +P Sbjct: 383 FVVRHNPTGTVLFMGQVMEP 402 >3LW2-A nrPDB Length = 379 Score = 282 bits (721), Expect = 2e-76, Method: Compositional matrix adjust. Identities = 145/370 (39%), Positives = 229/370 (61%), Gaps = 4/370 (1%) Query: 31 GSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVN--GV 88 ++ G++VF Q+V++ N+V SP+G++SVL MLQ+ G+T++Q+ M + VN G Sbjct: 12 ATDFGVKVFQQVVQASKDRNVVFSPYGVSSVLAMLQMTTAGKTRRQIQDAMGFKVNEKGT 71 Query: 89 GKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPAS 148 L++++K ++ NK+ ++ A+A+FV+ E+ F+ +FQ V+ V+F + Sbjct: 72 AHALRQLSKELMGPWNKNEISTADAIFVQRDLELVQGFMPHFFKLFQTMVKQVDFSEVER 131 Query: 149 ACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFV 208 A IN WV+ T+ MI++LL+ +D LTRLVLVNA+YF G WK+ F +T +R F Sbjct: 132 ARFIINDWVERHTKGMINDLLAKGAVDE-LTRLVLVNALYFSGQWKTPFLEASTHQRLFH 190 Query: 209 AADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAI 268 +DG + VPM+AQ + F + P+ L Y+ +ELPY G+++SM IA P E LSA+ Sbjct: 191 KSDGSTVSVPMMAQSNKFNYTEFTTPDGLEYDVVELPYQGDTLSMFIAAPFEKDVHLSAL 250 Query: 269 IPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKIT 328 + + I W M +ILPKF+ + DL+ PL+ LG+ DMF ++ A+F + Sbjct: 251 TNILDAELIRQWKGNMTRLPRLLILPKFSLETEVDLRGPLEKLGMPDMFSATLADFTSL- 309 Query: 329 TGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPTGA 388 + E L V+ LQK +IEV+E GT AS++T ++ AR +P ++DR FLF +RHNPT Sbjct: 310 SDQEQLSVAQALQKVRIEVNESGTVASSSTAFVISARMAPTEMVIDRSFLFVVRHNPTET 369 Query: 389 VLFMGQINKP 398 +LFMGQ+ +P Sbjct: 370 ILFMGQVMEP 379 >4KDS-A nrPDB Length = 386 Score = 274 bits (701), Expect = 4e-74, Method: Compositional matrix adjust. Identities = 148/375 (39%), Positives = 229/375 (61%), Gaps = 7/375 (1%) Query: 26 SLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGV 85 +L+E ++ G++VF+Q+ ++ N+ SP+G+A++L M QLGA G T K L + + + Sbjct: 14 NLQEKQTDFGMRVFSQVAQNSKGSNLAFSPYGVATILAMAQLGAGGNTLKTLNAKLGFSL 73 Query: 86 N--GVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNF 143 G+ + + + + I S++ V +A+ V V+ +E F FQ ++F Sbjct: 74 QERGMARQQRLLQRDISSEEG---VELASGVMVERKMALEKGFRRGLGKAFQASPHQLDF 130 Query: 144 EDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTK 203 P A D INAWV + T I + LS + TR+VL+NA++F+GLWK F P+ T+ Sbjct: 131 SRPDQALDIINAWVSDHTAGTIPSFLSSGALTDE-TRMVLLNALHFQGLWKVPFDPKMTE 189 Query: 204 KRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESST 263 +R F A+G S VPM+ F+ G P+ + Y+ IE+PY GES+SML+ P E T Sbjct: 190 ERLFHCANGSSVPVPMMRLTHRFKYGEFVTPDGVDYDVIEVPYEGESLSMLLVSPFEPET 249 Query: 264 PLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKAN 323 P+S++ ++T+ + W M + Q++LP+FT ++ +LK L +G+ DMF+ +KA+ Sbjct: 250 PVSSLSSELTTQRLQQWRQEMRSVKRQLVLPRFTLDSEVELKSILIQMGLGDMFNLAKAD 309 Query: 324 FAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRH 383 F +ITT + L VS +LQK KIEV+E+GTKASAAT AIL +R + ++RPFLF I H Sbjct: 310 FTRITT-EQPLCVSKVLQKVKIEVNEEGTKASAATAAILFSRMAVEEITMNRPFLFLIHH 368 Query: 384 NPTGAVLFMGQINKP 398 TGAVLFMGQ+N+P Sbjct: 369 KSTGAVLFMGQVNQP 383 >4DTE-A nrPDB Length = 374 Score = 270 bits (690), Expect = 7e-73, Method: Compositional matrix adjust. Identities = 146/374 (39%), Positives = 220/374 (58%), Gaps = 7/374 (1%) Query: 27 LEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVN 86 +++ ++ G+QVF + V+S P N+ +SP+GIASVLGM Q+GA G T K LA M Y + Sbjct: 3 IQDKQTDFGLQVFAEAVQSAPDRNLALSPYGIASVLGMAQMGAYGATLKLLASKMGYSLQ 62 Query: 87 --GVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFE 144 G+ K+ + + + + S+ D V VA+ V V +E F FQ ++F Sbjct: 63 ERGMPKLQRLLQRDLASE---DGVEVASGVMVDRKIILEKVFRRSLSKAFQSVPHQIDFS 119 Query: 145 DPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKK 204 P A IN+W + T MI L P + LTRLV +NA++F G+WK+ F P NT++ Sbjct: 120 QPEMARQVINSWTSDHTDGMISEFL-PSGVLSELTRLVFLNALHFHGVWKTPFDPRNTRE 178 Query: 205 RTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTP 264 + F +G + VPM+ F G + + + Y+ IE+PY GESISML+ P E P Sbjct: 179 QLFHTVNGSAVSVPMMTTTQKFNYGEFVSKDGVDYDVIEMPYEGESISMLLVTPFEKDVP 238 Query: 265 LSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANF 324 LSA+ +S+ I W M Q+ +P+F+ + DLK L +G+ D+F S+A+F Sbjct: 239 LSALNKELSSSRIHQWRQEMRKISKQLSIPRFSMDTEIDLKSTLSRMGLGDIFSQSRADF 298 Query: 325 AKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHN 384 ++ITT E L VS +LQ+ K+EV+E+GTK S+AT A++ +R + +DRPF F I+H Sbjct: 299 SRITT-EEPLCVSKVLQRVKLEVNEEGTKGSSATAAVIYSRMAVEEITLDRPFFFLIQHK 357 Query: 385 PTGAVLFMGQINKP 398 PTGA+LF GQ+ +P Sbjct: 358 PTGALLFSGQLTQP 371 >6EE5-A nrPDB Length = 379 Score = 223 bits (567), Expect = 2e-58, Method: Compositional matrix adjust. Identities = 144/377 (38%), Positives = 207/377 (54%), Gaps = 23/377 (6%) Query: 27 LEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGV- 85 L E ++ ++ ++ KS P NI SP I+S L ML LGA G T Q+ + + Sbjct: 21 LAEANTDFAFSLYRELAKSSPDKNIFFSPVSISSALAMLSLGAKGDTHTQILEGLGFNSE 80 Query: 86 ----NGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNV 141 G +L+ +N+ K + T AN +FV + ++ F+ +K ++Q E +V Sbjct: 81 ADIHQGFQHLLQTLNRP----KGLQLKT-ANGLFVDKSLKLLDSFLEDSKKLYQAEAFSV 135 Query: 142 NFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPEN 201 +F DP A IN WV+ +T I +LL D VL VLVNA+YFKG WK F PEN Sbjct: 136 DF-DPEEAKKQINDWVEKQTNGKIKDLLKDLDSDTVL---VLVNAIYFKGKWKKPFDPEN 191 Query: 202 TKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTES 261 TK+ F + + +VPM++Q F ++L +ELPY G + SMLI LP E Sbjct: 192 TKEEDFHVDEKTTVKVPMMSQKGKFYY---YHDDELSCKVLELPYKGNA-SMLIILPDEG 247 Query: 262 STPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSK 321 L + ++ +T+ W+ + + V++ LPKF DLKE L LGITD+F S Sbjct: 248 G--LQHLEQSLTPETLSKWLKSLTRRSVELYLPKFKIEGTYDLKEVLSNLGITDLF-SPG 304 Query: 322 ANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFI 381 A+ + IT E L+VS + KA +EV+E+GT+A+AAT I S PP F DRPFLF I Sbjct: 305 ADLSGIT--EEKLYVSKAVHKAVLEVNEEGTEAAAATFLEAIPMSIPPEFKADRPFLFLI 362 Query: 382 RHNPTGAVLFMGQINKP 398 R N TG++LFMG++ P Sbjct: 363 RENKTGSILFMGKVVNP 379 >3F02-A nrPDB Length = 359 Score = 212 bits (539), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 115/344 (33%), Positives = 201/344 (58%), Gaps = 10/344 (2%) Query: 28 EELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNG 87 EE ++ + ++N++ + +NI+ SP IA +GM++LGA G T+K++ M Y Sbjct: 20 EEAIADLSVNMYNRLRATGEDENILFSPLSIALAMGMMELGAQGSTQKEIRHSMGYDSLK 79 Query: 88 VGK---ILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFE 144 G+ LK+ + + +K+++ ++ +AN++FV+N + F+ K F V +V+F Sbjct: 80 NGEEFSFLKEFSNMVTAKESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNAAVNHVDFS 139 Query: 145 DPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKK 204 + + IN WV+N T +++ +L+SP D T L L+NAVYFKG WKS+F+PENT+ Sbjct: 140 QNVAVANYINKWVENNTNNLVKDLVSPRDFDAA-TYLALINAVYFKGNWKSQFRPENTRT 198 Query: 205 RTFVAADGKSYQVPMLAQLSVFRCGSTS-APNDLW--YNFIELPYHGESISMLIALPTES 261 +F D Q+PM+ Q F G S N+ Y +E+PY G+ ISM++ L + Sbjct: 199 FSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVL-SRQ 257 Query: 262 STPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSK 321 PL+ + P + + ++ W + + ++V+V LP+FT + DLK+ LK LGIT++F Sbjct: 258 EVPLATLEPLVKAQLVEEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKALGITEIF-IKD 316 Query: 322 ANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIAR 365 AN ++ E + +S + K+ +EV+E+G++A+A + I I+R Sbjct: 317 ANLTGLSDNKE-IFLSKAIHKSFLEVNEEGSEAAAVSGMIAISR 359 >1BY7-A nrPDB Length = 382 Score = 184 bits (468), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 116/378 (30%), Positives = 194/378 (51%), Gaps = 23/378 (6%) Query: 36 IQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKI 95 + +F + K+ P N+ +SP I+S + M+ +G+ G T+ Q+A V+++ N VG KI Sbjct: 13 LNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQF--NEVGAAADKI 70 Query: 96 N-------KAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNF-EDPA 147 + AI + ++ N +F + ++ ++ + + E + V+F E Sbjct: 71 HSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLECAE 130 Query: 148 SACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTF 207 A IN+WVK +T+ I NLL +DG TR+VLVNAVYFKG WK+ F+ + F Sbjct: 131 EARKKINSWVKTQTKGKIPNLLPEGSVDGD-TRMVLVNAVYFKGKWKTPFEKKLNGLYPF 189 Query: 208 VAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTE---SSTP 264 + V M+ G DL +ELPY G+ +SM + LP E ST Sbjct: 190 RVNSAQRTPVQMMYLREKLNIGYIE---DLKAQILELPYAGD-VSMFLLLPDEIADVSTG 245 Query: 265 LSAIIPHISTKTIDSWMS--IMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKA 322 L + I+ ++ W S M V+V +P+F +L+ L+ +G+ D F+ +A Sbjct: 246 LELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRA 305 Query: 323 NFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARS--SPPWFIVDRPFLFF 380 NF+ ++ +L +S + +A ++V+E+GT+A+A T ++ R+ P F+ D PFLF Sbjct: 306 NFSGMSE-RNDLFLSEVFHQAMVDVNEEGTEAAAGTGGVMTGRTGHGGPQFVADHPFLFL 364 Query: 381 IRHNPTGAVLFMGQINKP 398 I H T +LF G+ + P Sbjct: 365 IMHKITNCILFFGRFSSP 382 >1JJO-C nrPDB Length = 261 Score = 184 bits (466), Expect = 9e-47, Method: Compositional matrix adjust. Identities = 100/265 (37%), Positives = 162/265 (61%), Gaps = 7/265 (2%) Query: 103 KNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETR 162 +N+ ++ +AN++FV+N + F+ K F EV +V+F + +SIN WV+N T Sbjct: 1 ENQYVMKLANSLFVQNGFHVNEEFLQMLKMYFNAEVNHVDFSQNVAVANSINKWVENYTN 60 Query: 163 DMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQ 222 ++ +L+SP+ DGV T L L+NAVYFKG WKS+F+PENT+ +F D Q+PM+ Q Sbjct: 61 SLLKDLVSPEDFDGV-TNLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQ 119 Query: 223 LSVFRCGSTS-APNDLW--YNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDS 279 F G S N+ Y +E+PY G+ ISM++AL + PL+ + P + + I+ Sbjct: 120 QGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLAL-SRQEVPLATLEPLLKAQLIEE 178 Query: 280 WMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVSHI 339 W + + ++V+V LP+FT + DLK+ LK LG+T++F AN ++ E L +S Sbjct: 179 WANSVKKQKVEVYLPRFTVEQEIDLKDILKALGVTEIF-IKDANLTAMSDKKE-LFLSKA 236 Query: 340 LQKAKIEVSEDGTKASAATTAILIA 364 + K+ IEV+E+G++A+AA+ I I+ Sbjct: 237 VHKSCIEVNEEGSEAAAASGMIAIS 261 >4EB1-I nrPDB Length = 440 Score = 180 bits (456), Expect = 1e-45, Method: Compositional matrix adjust. Identities = 114/370 (30%), Positives = 195/370 (52%), Gaps = 24/370 (6%) Query: 48 HDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGV------NGVGKILKKINKAIVS 101 +DNI +SP I++ M +LGA T +QL V ++ + + K+N + Sbjct: 73 NDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYR 132 Query: 102 KKNKDIVTV-ANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDS-INAWVKN 159 K NK V AN +F + + ++ V+ +++ ++F++ A + IN WV N Sbjct: 133 KANKASKLVSANRLFGDKSLTFNETYQDISELVYGAKLQPLDFKENAEQSRAAINKWVSN 192 Query: 160 ETRDMIDNLLSPDLIDGVL-------TRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADG 212 +T I +++ + I+ ++ T LVLVN +YFKGLWKS+F PENT+K F ADG Sbjct: 193 KTEGRITDVIPSEAINVLVLVNTRTSTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADG 252 Query: 213 KSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHI 272 +S M+ Q FR + + +ELP+ G+ I+M++ LP + L+ + + Sbjct: 253 ESCSASMMYQEGKFRYRRVAEGTQV----LELPFKGDDITMVLILPKPEKS-LAKVEKEL 307 Query: 273 STKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITT-GS 331 + + + W+ + + V +P+F LKE L+ +G+ D+F K+ I G Sbjct: 308 TPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVAEGR 367 Query: 332 ENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPP---WFIVDRPFLFFIRHNPTGA 388 ++L+VS KA +EV+E+G++A+A+T ++ RS P F +RPFL FIR P Sbjct: 368 DDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNT 427 Query: 389 VLFMGQINKP 398 ++FMG++ P Sbjct: 428 IIFMGRVANP 437 >3NDA-A nrPDB Length = 377 Score = 177 bits (449), Expect = 7e-45, Method: Compositional matrix adjust. Identities = 118/366 (32%), Positives = 192/366 (52%), Gaps = 26/366 (7%) Query: 45 SRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGV-----NGVGKILKKINKAI 99 S P N+ SP+ +++ +GM GA G+T+++L+ + + GV + + Sbjct: 24 SGPEKNVFFSPYSVSTAMGMAFAGARGQTQQELSQGLGFSDVDLTDAGVLDAYTHHTERL 83 Query: 100 VSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFE-DPASACDSINAWVK 158 S + + VANA ++ + + + + F E+ V+F +P +A D +N WVK Sbjct: 84 KSTPSNSTLDVANAAAIQRTLALLNSYESALQSSFGAELHKVDFAGEPQAAVDFVNNWVK 143 Query: 159 NETRDMIDNL----LSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKS 214 +T D I+ L L PD T LVL+NA+YFKG W + F E+T+KR F Sbjct: 144 RKTHDKIEKLFNEPLDPD------TLLVLLNAIYFKGEWNTAFVKEHTEKRQFFNGGVTP 197 Query: 215 YQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHIST 274 +V + + + +DL +ELPY G +M I LP E +T + + +++ Sbjct: 198 VEVDTMRLEARIKY---RFFDDLQVEVVELPYRGLDYTMAILLPKE-NTGVEGLKQNLTI 253 Query: 275 KTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENL 334 +++S + +++ V+LPKF + LK PL+ LGI +F+S A+ + I GS L Sbjct: 254 DRFQNYLSDLRERKITVLLPKFKLETKYSLKAPLQSLGIKQIFESG-ADLSGINDGS--L 310 Query: 335 HVSHILQKAKIEVSEDGTKASAATTAILIARS---SPPWFIVDRPFLFFIRHNPTGAVLF 391 VS + KA +EV+E+GT A+A T +++ S P F VD PFLFFIR+ T + F Sbjct: 311 RVSAVEHKAVVEVNEEGTVAAATTGVVIVPYSLGPEPVVFRVDHPFLFFIRNTRTDDIFF 370 Query: 392 MGQINK 397 +GQ+NK Sbjct: 371 VGQVNK 376 >4P0F-A nrPDB Length = 393 Score = 176 bits (445), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 110/356 (30%), Positives = 182/356 (51%), Gaps = 12/356 (3%) Query: 35 GIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKK 94 I V+ ++ +P +NIV SP I + M +LGA+ T QL + + +I Sbjct: 18 SINVYGKLSGQKPGENIVFSPFSIQTCAAMARLGAENETATQLDQGLGLASSDPEQIAHS 77 Query: 95 INKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSIN 154 ++ + + ++ I+ +AN +FV + ++ F F ++V+F A +IN Sbjct: 78 FHQVLAAYQDSQILRIANKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDFSKNVQAAATIN 137 Query: 155 AWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKS 214 WV+ T +I +L+ D+++ +RLVLVNA++FKG W+ +F T+ TF ++ Sbjct: 138 NWVEQRTNHLIKDLVPADVLNSE-SRLVLVNAIHFKGTWQHQFAKHLTRPDTFHLDGERT 196 Query: 215 YQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHIST 274 QVPM++ FR A + + +ELPY +SMLI LP + T L A+ + Sbjct: 197 VQVPMMSLKERFRYADLPALDAMA---LELPYKDSDLSMLIVLPN-TKTGLPALEEKLRL 252 Query: 275 KTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENL 334 T+ + +V + LP+F A Q +L E + LG++ MF S +A F K+ E L Sbjct: 253 TTLSQITQSLYETKVALKLPRFKAEFQVELSEVFQKLGMSRMF-SDQAEFGKMLQSPEPL 311 Query: 335 HVSHILQKAKIEVSEDGTKASAAT------TAILIARSSPPWFIVDRPFLFFIRHN 384 VS I+ KA IEV+E+GT+A+AAT +++ P F D PF + + H Sbjct: 312 KVSAIIHKAFIEVNEEGTEAAAATGMAVRRKRAIMSPEEPIEFFADHPFTYVLVHQ 367 >4GA7-A nrPDB Length = 389 Score = 176 bits (445), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 129/387 (33%), Positives = 202/387 (52%), Gaps = 23/387 (5%) Query: 27 LEELGS-NT--GIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRY 83 +E+L S NT + +F + ++ P NI ISP I+S + M+ LG G T QL+ + Sbjct: 11 MEQLSSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHF 70 Query: 84 G-VNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVN 142 V V + +N I + I+ +AN ++ + F+ + + ++ +V+ Sbjct: 71 NTVEEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVD 130 Query: 143 FEDPAS-ACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPEN 201 F+ + A +IN WVK +T I LL+ ++D +T+LVLVNA+YFKG WK +F E Sbjct: 131 FQHASEDARKTINQWVKGQTEGKIPELLASGMVDN-MTKLVLVNAIYFKGNWKDKFMKEA 189 Query: 202 TKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALP--- 258 T F V M+ Q F G DL +ELPY GE +SM+I LP Sbjct: 190 TTNAPFRLNKKDRKTVKMMYQKKKFAYGYIE---DLKCRVLELPYQGEELSMVILLPDDI 246 Query: 259 TESSTPLSAIIPHISTKTIDSWMSIMVPK-----RVQVILPKFTAVAQTDLKEPLKVLGI 313 + ST L I ++ + + W P+ V V LP+F L L LG+ Sbjct: 247 EDESTGLKKIEEQLTLEKLHEWTK---PENLDFIEVNVSLPRFKLEESYTLNSDLARLGV 303 Query: 314 TDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPW--F 371 D+F+SSKA+ + ++ G+ ++ +S I+ K+ +EV+E+GT+A+AAT I P F Sbjct: 304 QDLFNSSKADLSGMS-GARDIFISKIVHKSFVEVNEEGTEAAAATAGIATFCMDDPEENF 362 Query: 372 IVDRPFLFFIRHNPTGAVLFMGQINKP 398 D PFLFFIRHN +G++LF+G+ + P Sbjct: 363 TADHPFLFFIRHNSSGSILFLGRFSSP 389 >1ATT-A nrPDB Length = 429 Score = 174 bits (441), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 113/363 (31%), Positives = 187/363 (51%), Gaps = 18/363 (4%) Query: 48 HDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGV------NGVGKILKKINKAIVS 101 +DNI +SP I++ M +LGA T QL V ++ + + K+N + Sbjct: 70 NDNIFLSPLSISTAFAMTKLGACNNTLTQLMEVFKFDTISEKTSDQIHFFFAKLNCRLYR 129 Query: 102 KKNKDIVTV-ANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACD-SINAWVKN 159 K NK V AN +F + + ++ V+ +++ ++F+ A +IN W+ N Sbjct: 130 KANKSSELVSANRLFGDKSITFNETYQDISEVVYGAKLQPLDFKGNAEQSRLTINQWISN 189 Query: 160 ETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPM 219 +T I +++ P I+ T LVLVN +YFKGLWKS+F PENT+K F ADG+S V M Sbjct: 190 KTEGRITDVIPPQAINE-FTVLVLVNTIYFKGLWKSKFSPENTRKELFYKADGESCSVLM 248 Query: 220 LAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDS 279 + Q S FR + + +ELP+ G+ I+M++ LP T L+ + ++ + Sbjct: 249 MYQESKFRYRRVAESTQV----LELPFKGDDITMVLILPKLEKT-LAKVEQELTPDMLQE 303 Query: 280 WMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITT-GSENLHVSH 338 W+ + + V +P+F +KE L+ +G+ D+F K+ I G +L+VS Sbjct: 304 WLDELTETLLVVHMPRFRIEDSFSVKEQLQDMGLEDLFSPEKSRLPGIVAEGRSDLYVSD 363 Query: 339 ILQKAKIEVSEDGTKASAATTAILIAR---SSPPWFIVDRPFLFFIRHNPTGAVLFMGQI 395 KA +EV+E+G++A+A+T + R S F +RPFL IR ++FMG++ Sbjct: 364 AFHKAFLEVNEEGSEAAASTVISIAGRSLNSDRVTFKANRPFLVLIREVALNTIIFMGRV 423 Query: 396 NKP 398 P Sbjct: 424 ANP 426 >5NCS-A nrPDB Length = 375 Score = 166 bits (419), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 113/385 (29%), Positives = 201/385 (52%), Gaps = 25/385 (6%) Query: 24 PLSLEELGSNTGIQVFNQIVKSRPH---DNIVISPHGIASVLGMLQLGADGRTKKQLAMV 80 PL E++ + F+ + +R H N+ ISP ++ L M GA G T ++ Sbjct: 2 PLGSEKIEKDNAF-AFDLLQTTRKHVTEANVFISPLSVSMALNMTLNGAAGVTADEMKTA 60 Query: 81 MR---YGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCE 137 +R Y + + + + +A++ + +AN+++ K ++ PF+ N+ + E Sbjct: 61 LRETGYTMEDINEYSHSLREALLKVDPSTTIGMANSIWYKQGELVKEPFILANRTHYDAE 120 Query: 138 VRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRF 197 V+ V+F PA+ +IN W +T D I +L D I G + L+NAVYFKG+W ++F Sbjct: 121 VKAVDFSSPAT-LPAINGWCAQKTNDKITKIL--DYIPGN-AFMYLINAVYFKGIWVTQF 176 Query: 198 QPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIAL 257 + +TK+ F ADG + +V M+AQ S F G T+ D ++E+ Y ++ SM++ L Sbjct: 177 KKSDTKRAPFRKADGTTQEVNMMAQKSTF--GYTT---DECCQYLEMDYGNKAFSMIVML 231 Query: 258 PTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDL-KEPLKVLGITDM 316 P E T +I + K + + P +V + +P+F + L K+ L +G+ Sbjct: 232 PNEGQTTRD-VIEQLDNKHWSMIIKGIRPTQVSLRMPRFKTECKYGLEKKILPEMGMNVP 290 Query: 317 FDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPW----FI 372 F + A+F IT + + +S ++ K ++V E+GT+A+A T ++ SSP F Sbjct: 291 F-TETADFPGITDAA--IFISRVIHKTFVQVDEEGTEAAAVTAVEMVKTSSPSTTPINFH 347 Query: 373 VDRPFLFFIRHNPTGAVLFMGQINK 397 +++PF+F IR TG +LF+G+I + Sbjct: 348 INKPFVFAIREKSTGVILFIGEIGE 372 >1UHG-A nrPDB Length = 385 Score = 164 bits (415), Expect = 7e-41, Method: Compositional matrix adjust. Identities = 116/380 (30%), Positives = 196/380 (51%), Gaps = 27/380 (7%) Query: 38 VFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRY-------------- 83 VF ++ ++NI P I S L M+ LGA T+ Q+ V+R+ Sbjct: 14 VFKELKVHHANENIFYCPIAIMSALAMVYLGAKDSTRTQINKVVRFDKLPGFGDSIEAQC 73 Query: 84 --GVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNV 141 VN V L+ I I + ++A+ ++ + I ++ K++++ + + Sbjct: 74 GTSVN-VHSSLRDILNQITKPNDVYSFSLASRLYAEERYPILPEYLQCVKELYRGGLEPI 132 Query: 142 NFEDPA-SACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPE 200 NF+ A A + IN+WV+++T +I N+L P +D T +VLVNA+ FKGLW+ F+ E Sbjct: 133 NFQTAADQARELINSWVESQTNGIIRNVLQPSSVDS-QTAMVLVNAIVFKGLWEKAFKDE 191 Query: 201 NTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTE 260 +T+ F + +S V M+ Q+ +FR S ++ +ELP+ ++SML+ LP E Sbjct: 192 DTQAMPFRVTEQESKPVQMMYQIGLFRVASMASEK---MKILELPFASGTMSMLVLLPDE 248 Query: 261 SSTPLSAIIPHISTKTIDSWMS--IMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFD 318 S L + I+ + + W S +M ++++V LP+ + +L L +GITD+F Sbjct: 249 VSG-LEQLESIINFEKLTEWTSSNVMEERKIKVYLPRMKMEEKYNLTSVLMAMGITDVFS 307 Query: 319 SSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFL 378 SS AN + I++ +E+L +S + A E++E G + + A + A S F D PFL Sbjct: 308 SS-ANLSGISS-AESLKISQAVHAAHAEINEAGREVVGSAEAGVDAASVSEEFRADHPFL 365 Query: 379 FFIRHNPTGAVLFMGQINKP 398 F I+H T AVLF G+ P Sbjct: 366 FCIKHIATNAVLFFGRCVSP 385 >4ZK0-A nrPDB Length = 390 Score = 163 bits (413), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 128/397 (32%), Positives = 204/397 (51%), Gaps = 33/397 (8%) Query: 26 SLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMR--- 82 SL E + +F Q KS+ +NI SP I S LGM+ LGA T +Q+ V+ Sbjct: 3 SLSEANTKFMFDLFQQFRKSKE-NNIFYSPISITSALGMVLLGAKDNTAQQIKKVLHFDQ 61 Query: 83 -----------YGVNGVGKILKKINKAIVS-KKNKDI--VTVANAVFVKNASEIEVPFVT 128 Y V+ G + + K + K+ D + +AN +F + ++ Sbjct: 62 VTENTTGKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQEYLD 121 Query: 129 RNKDVFQCEVRNVNFED-PASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAV 187 K +Q V +V+F + P + IN+WV+++T + I NL+ P+ G T LVLVNA+ Sbjct: 122 AIKKFYQTSVESVDFANAPEESRKKINSWVESQTNEKIKNLI-PEGNIGSNTTLVLVNAI 180 Query: 188 YFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYH 247 YFKG W+ +F E+TK+ F + M+ Q + F S D+ +E+PY Sbjct: 181 YFKGQWEKKFNKEDTKEEKFWPNKNTYKSIQMMRQYTSFHFASLE---DVQAKVLEIPYK 237 Query: 248 GESISMLIALPTESSTPLSAIIPHISTKTIDSWMSI--MVPKRVQVILPKFTAVAQTDLK 305 G+ +SM++ LP E L + ++ + + W S+ M RV + LP+F DLK Sbjct: 238 GKDLSMIVLLPNEID-GLQKLEEKLTAEKLMEWTSLQNMRETRVDLHLPRFKVEESYDLK 296 Query: 306 EPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIAR 365 + L+ +G+ D+F+ A+ + + TGS L +S +L KA +EV+E+G +A+AAT + Sbjct: 297 DTLRTMGMVDIFNGD-ADLSGM-TGSRGLVLSGVLHKAFVEVTEEGAEAAAATAVVGFG- 353 Query: 366 SSP----PWFIVDRPFLFFIRHNPTGAVLFMGQINKP 398 SSP F + PFLFFIR N T ++LF G+ + P Sbjct: 354 SSPTSTNEEFHCNHPFLFFIRQNKTNSILFYGRFSSP 390 >4AJT-A nrPDB Length = 427 Score = 158 bits (399), Expect = 4e-39, Method: Compositional matrix adjust. Identities = 113/384 (29%), Positives = 204/384 (53%), Gaps = 28/384 (7%) Query: 28 EELGSNTGIQVFNQIVK-SRPHD-NIVISPHGIASVLGMLQLGADGRTKKQ------LAM 79 ++L + T FN + K S HD N++ SP G++ + L LG G TK Q L Sbjct: 56 QQLSNETSSFGFNLLRKISMRHDGNVIFSPFGLSVAMVNLMLGTKGETKVQIENGLNLQA 115 Query: 80 VMRYGVNGVGKILKKINKAIVSKKNKDI-VTVANAVFVKNASEIEVPFVTRNKDVFQCEV 138 + + G + + KK+ + S N+D+ ++ + F+ +I+ + +K F E Sbjct: 116 LSQAGPLILPALFKKVKETFSS--NRDLGLSQGSFAFIHKDFDIKETYFNLSKKYFDIEY 173 Query: 139 RNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGV--LTRLVLVNAVYFKGLWKSR 196 ++NF++ + A IN + ET I P L D + T+L+LV+ V FKG W + Sbjct: 174 VSINFQNSSQARGLINHCIVKETEGKI-----PKLFDEINPETKLILVDYVLFKGKWLTP 228 Query: 197 FQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWY--NFIELPYHGESISML 254 F P T+ TF ++ +VPM+ +R G+ ++ D + + ++LPY G + +ML Sbjct: 229 FDPSFTEADTFHLDKYRAIKVPMM-----YREGNFTSTFDKKFRCHILKLPYQGNA-TML 282 Query: 255 IALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGIT 314 + L E + A+ +++ +++W+ M ++++V PKF + ++ E LK +GI Sbjct: 283 VVL-MEKTGDYLALEDYLTVDLVETWLQNMKTRKMEVFFPKFKLNQRYEMHELLKQMGIR 341 Query: 315 DMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVD 374 +F +S A+ ++++ + NL VS +LQ++ +EV E GT+A + T + +IA S PP V+ Sbjct: 342 RLFSTS-ADLSELSAMARNLQVSRVLQQSVLEVDERGTEAVSGTLSEIIAYSMPPAIKVN 400 Query: 375 RPFLFFIRHNPTGAVLFMGQINKP 398 RPF F I + +LF+G++ P Sbjct: 401 RPFHFIIYEEMSRMLLFLGRVVNP 424 >6CJ7-A nrPDB Length = 390 Score = 157 bits (396), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 109/367 (29%), Positives = 187/367 (50%), Gaps = 10/367 (2%) Query: 35 GIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKK 94 G+ VF Q+ + N+ SP I +L MLQ GA G T ++ ++ +I KK Sbjct: 21 GVNVFKQMATEQ-SGNLAASPFSITILLAMLQQGAAGNTLDEITRALQMTPEKSAEIFKK 79 Query: 95 INKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSIN 154 +N+ I + +++I+ AN VF+ + F + F ++ F PA A +IN Sbjct: 80 VNEEIQKRNSRNILKTANNVFLSENFNLNPQFKRIAVNNFDSDLTPTYFGKPALAAQNIN 139 Query: 155 AWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKS 214 +W+ ++T D ID L+SPD + G T++V+VNAVYFKGLW+ F+ + T+KR F G+ Sbjct: 140 SWIASKTNDKIDKLVSPDDLSGN-TQMVMVNAVYFKGLWEIPFREQATQKRNFTLNGGEK 198 Query: 215 YQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHIST 274 + F+ G T P + LP+ S+++ LP +SS + A++ +S Sbjct: 199 KVASFMQTRRYFKAG-THKP--AMAKVVVLPFEYNEYSLIVVLPLKSSN-VDALLSSLSM 254 Query: 275 KTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENL 334 + + S++ + PK V + LPKF+ A +L+ L +G++ +F + + GS + Sbjct: 255 EDVASFLD-LPPKDVALELPKFSIKADINLEPVLNKMGVSSIFTQQAELYNLGSHGSLSP 313 Query: 335 HVSHILQKAKIEVSEDG--TKASAATTAILIARSSPP-WFIVDRPFLFFIRHNPTGAVLF 391 VS L A + + E G A+ + A+ ++ P +F ++PFL + N + LF Sbjct: 314 QVSSALHSAVLTIDERGGSAAAATSFAAVALSYDEPSLYFRANKPFLAILWDNRSSIPLF 373 Query: 392 MGQINKP 398 M +I P Sbjct: 374 MARIMDP 380 >1K9O-I nrPDB Length = 378 Score = 155 bits (393), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 118/376 (31%), Positives = 192/376 (51%), Gaps = 12/376 (3%) Query: 27 LEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVN 86 L E Q+F+++VK+ P N+V+S + LG L L + G + +L + + Sbjct: 11 LRESNDQFTAQMFSEVVKANPGQNVVLSAFSVLPPLGQLALASVGESHDELLRALALPND 70 Query: 87 GVGK-ILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFED 145 V K + +N+ + + K D+ +A+ ++V E+ F ++DVF EV+NV+F Sbjct: 71 NVTKDVFADLNRGVRAVKGVDL-KMASKIYVAKGLELNDDFAAVSRDVFGSEVQNVDFVK 129 Query: 146 PASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKR 205 A +IN WV+++T + I NL+ PD +D TR VLVNA+YFKG WK +F E T R Sbjct: 130 SVEAAGAINKWVEDQTNNRIKNLVDPDALDET-TRSVLVNAIYFKGSWKDKFVKERTMDR 188 Query: 206 TFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPL 265 F + K+ +VP + R +L IE+ Y G+ SM+I LP + + Sbjct: 189 DFHVSKDKTIKVPTMIGKKDVRYADVP---ELDAKMIEMSYEGDQASMIIILPNQVDG-I 244 Query: 266 SAIIPHIST-KTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANF 324 +A+ + K + + V++ LPKF TDLKE L + I +F A Sbjct: 245 TALEQKLKDPKALSRAEERLYNTEVEITLPKFKIETTTDLKEVLSNMNIKKLFTPGAARL 304 Query: 325 AKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARS--SPPWFIVDRPFLFFIR 382 + E+L V +QKA IEV+E+G +A+AA ++ +S P +DRPF F ++ Sbjct: 305 ENLLKTKESLTVDAAIQKAFIEVNEEGAEAAAANAFGIVPKSLILYPEVHIDRPFYFELK 364 Query: 383 HNPTGAVLFMGQINKP 398 + G +F G++ +P Sbjct: 365 ID--GIPMFNGKVIEP 378 >2VDY-A nrPDB Length = 373 Score = 154 bits (389), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 106/370 (28%), Positives = 189/370 (51%), Gaps = 24/370 (6%) Query: 38 VFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNG-----VGKIL 92 ++ +V P NI ISP I+ L ML LG G T+ QL + + + + + Sbjct: 18 LYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGF 77 Query: 93 KKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDS 152 + +++ +T+ NA+F+ + E+ F K ++ EV +NF+D A+A Sbjct: 78 QHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLAMNFQDWATASRQ 137 Query: 153 INAWVKNETR----DMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFV 208 IN++VKN+T+ D+ L SP + LVLVN ++FKG W F +T++ F Sbjct: 138 INSYVKNKTQGKIVDLFSGLDSPAI-------LVLVNYIFFKGTWTQPFDLASTREENFY 190 Query: 209 AADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAI 268 + +VPM+ Q S S ++L +++ Y G I LP + ++ + Sbjct: 191 VDETTVVKVPMMLQSSTI---SYLHDSELPCQLVQMNYVGNGTVFFI-LPDKG--KMNTV 244 Query: 269 IPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKIT 328 I +S TI+ W + + +V + +PK T DL + L+ +GI D+F +++ANF++IT Sbjct: 245 IAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLF-TTQANFSRIT 303 Query: 329 TGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPTGA 388 ++ L S ++ KA ++++E+GT+A+ A I RS P ++PF+ I + T + Sbjct: 304 QDAQ-LKSSKVVHKAVLQLNEEGTEAAGAMFLEAIPRSKPIILRFNQPFIIMIFDHFTWS 362 Query: 389 VLFMGQINKP 398 LF+ ++ P Sbjct: 363 SLFLARVMNP 372 >1SEK-A nrPDB Length = 378 Score = 154 bits (388), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 113/362 (31%), Positives = 184/362 (50%), Gaps = 10/362 (2%) Query: 27 LEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVN 86 L E Q+F+++VK+ P N+V+S + LG L L + G + +L + + Sbjct: 11 LRESNDQFTAQMFSEVVKANPGQNVVLSAFSVLPPLGQLALASVGESHDELLRALALPND 70 Query: 87 GVGK-ILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFED 145 V K + +N+ + + K D+ +A+ ++V E+ F ++DVF EV+NV+F Sbjct: 71 NVTKDVFADLNRGVRAVKGVDL-KMASKIYVAKGLELNDDFAAVSRDVFGSEVQNVDFVK 129 Query: 146 PASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKR 205 A +IN WV+++T + I NL+ PD +D TR VLVNA+YFKG WK +F E T R Sbjct: 130 SVEAAGAINKWVEDQTNNRIKNLVDPDALDET-TRSVLVNAIYFKGSWKDKFNKERTMDR 188 Query: 206 TFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPL 265 F + K+ +VP + R +L IE+ Y G+ SM+I LP + + Sbjct: 189 DFHVSKDKTIKVPTMIGKKDVRYADVP---ELDAKMIEMSYEGDQASMIIILPNQVDG-I 244 Query: 266 SAIIPHIST-KTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANF 324 +A+ + K + + V++ LPKF TDLKE L + I +F A Sbjct: 245 TALEQKLKDPKALSRAEERLYNTEVEIYLPKFKIETTTDLKEVLSNMNIKKLFTPGAARL 304 Query: 325 AKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSP--PWFIVDRPFLFFIR 382 + E+L+V +QKA IEV+E+G +A+AA + S P +++PF F ++ Sbjct: 305 ENLLKTKESLYVDAAIQKAFIEVNEEGAEAAAANAFKITTYSFHFVPKVEINKPFFFSLK 364 Query: 383 HN 384 +N Sbjct: 365 YN 366 >2H4Q-A nrPDB Length = 382 Score = 151 bits (381), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 104/352 (29%), Positives = 182/352 (51%), Gaps = 24/352 (6%) Query: 25 LSLEELGSNTG---IQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVM 81 +S+E++ ++ G + +FN++ ++ NI SP I+S L + L A G T +++A V+ Sbjct: 40 ISMEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVL 99 Query: 82 RYGV-----NGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQC 136 + +G ++L NK +N + AN ++V+ + ++ +K ++ Sbjct: 100 HFEQAENIHSGFKELLTAFNKP----RNNYSLRSANRIYVEKTYALLPTYLQLSKKYYKA 155 Query: 137 EVRNVNFED-PASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKS 195 E + VNF+ P + IN WV+ +T I NLLS D + TRL+LVNA+YFK W+ Sbjct: 156 EPQKVNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKAT-TRLILVNAIYFKAEWEV 214 Query: 196 RFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLI 255 +FQ E T + F + KS V M+ F N + IELPY +SM I Sbjct: 215 KFQAEKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMN---FKMIELPYVKRELSMFI 271 Query: 256 ALP---TESSTPLSAIIPHISTKTIDSWMS--IMVPKRVQVILPKFTAVAQTDLKEPLKV 310 LP + +T L + ++ + + W +M V + LPKF+ + DL++ L+ Sbjct: 272 LLPDDIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDRIDLRDTLRN 331 Query: 311 LGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAIL 362 +G+T F ++ A+F + T ++L +S ++ ++ + V E GT+A AAT I+ Sbjct: 332 MGMTTAF-TTNADFRGM-TDKKDLAISKVIHQSFVAVDEKGTEAVAATAVII 381 >2OL2-A nrPDB Length = 395 Score = 151 bits (381), Expect = 6e-37, Method: Compositional matrix adjust. Identities = 105/375 (28%), Positives = 195/375 (52%), Gaps = 34/375 (9%) Query: 38 VFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVN----------- 86 ++ + + P NI SP I+ L ML LGA TK Q+ + G+N Sbjct: 41 LYRALASAAPSQNIFFSPVSISMSLAMLSLGAGSSTKMQILEGL--GLNLQKSSEKELHR 98 Query: 87 GVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDP 146 G ++L+++N+ ++ +++ NA+F +++ FV+ K ++ + NF D Sbjct: 99 GFQQLLQELNQP----RDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDS 154 Query: 147 ASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRT 206 A A IN +V +T+ I +LL + V+ ++VN ++FK W++ F + T+++ Sbjct: 155 AGAMKQINDYVAKQTKGKIVDLLKNLDSNAVV---IMVNYIFFKAKWETSFNHKGTQEQD 211 Query: 207 FVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLS 266 F +VPM+++ + +L + +PY G + ++ I LP+E + Sbjct: 212 FYVTSETVVRVPMMSREDQYHY---LLDRNLSCRVVGVPYQGNATALFI-LPSEG--KMQ 265 Query: 267 AIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAK 326 + +S KT+ W+ + +++++ LPKF+ L++ L LGI+++F +S A+ + Sbjct: 266 QVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVF-TSHADLSG 324 Query: 327 ITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSS---PPWFIVDRPFLFFIRH 383 I+ S N+ VS ++ KA +EV E GT+A+AAT I RS+ + +RPFL FI Sbjct: 325 ISNHS-NIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVD 383 Query: 384 NPTGAVLFMGQINKP 398 N +LF+G++N+P Sbjct: 384 NN---ILFLGKVNRP 395 >5INW-A nrPDB Length = 421 Score = 146 bits (369), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 105/340 (30%), Positives = 176/340 (51%), Gaps = 20/340 (5%) Query: 35 GIQVFNQIVK-SRPHDNIVISPHGIASVLGMLQLGADGRTKKQL--AMVMRYGVNGVGK- 90 G +++ Q++ + P DNI SP IAS LG++ GA+G T+ +L A+ + ++G K Sbjct: 89 GFRLYKQVLGGAGPADNIFFSPLSIASALGVVTAGANGSTRAELDTALGFKEFLHGKKKA 148 Query: 91 ----ILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDP 146 ++N A+ + + N VF K + F +F+ VR+V+F D Sbjct: 149 KSMKYFARLNGALYKRSAGFELMGKNVVFSKKGLWLYRQFTRTVAHLFKSNVRSVDFGDS 208 Query: 147 ASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRT 206 +A + +NA+++ T +++S D T LV+VN +YFKG W ++F+P+ TK Sbjct: 209 KNAVELMNAYIEKVTSKKFPDVISDVDTD---TSLVIVNVIYFKGSWGNKFEPDLTKNVR 265 Query: 207 FVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLS 266 F S VP + Q + S + L ++LPY G SML+ +P + L Sbjct: 266 FWVNSSYSMMVPTMHQRAKL---SYTQDRKLRSTVVKLPYEG-GASMLVIVPHRTED-LP 320 Query: 267 AIIPHISTKTIDSWMSIMVPKR--VQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANF 324 + +S + ++ W+S++ P VQ+ LPKF DLK L +G++ MF S A+ Sbjct: 321 KVEESVSQEQLEEWLSLLGPSNHYVQLSLPKFKISVSYDLKAYLSAMGMSSMF-SYGADL 379 Query: 325 AKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIA 364 ++I TG + LHV I K+ + V+E+GT+A A T ++A Sbjct: 380 SRI-TGMQKLHVDKITHKSVLHVNEEGTEAKAETVVGIMA 418 >1JMJ-A nrPDB Length = 480 Score = 146 bits (368), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 102/362 (28%), Positives = 184/362 (50%), Gaps = 26/362 (7%) Query: 49 DNIVISPHGIASVLGMLQLGADGRTKKQLAMVM----------RYGVNGVGKILKKINKA 98 DNI I+P GI++ +GM+ LG G T +Q+ ++ +Y + + + +K+ Sbjct: 130 DNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVNASSKYEITTIHNLFRKLTHR 189 Query: 99 IVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVK 158 + + + N ++++ I + F T+ ++ + E + +F DPA + N +K Sbjct: 190 LFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEAQIADFSDPAFISKTNNHIMK 249 Query: 159 NETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVP 218 T+ +I + L ID T+++++N +YFKG W ++F E T F + + +V Sbjct: 250 -LTKGLIKDALEN--IDPA-TQMMILNCIYFKGSWVNKFPVEMTHNHNFRLNEREVVKVS 305 Query: 219 MLAQLSVFRCGSTSAPND--LWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKT 276 M+ G+ A ND L + ++L Y G ISMLI +P + S + + ++ + Sbjct: 306 MMQT-----KGNFLAANDQELDCDILQLEYVG-GISMLIVVPHKMSG-MKTLEAQLTPRV 358 Query: 277 IDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHV 336 ++ W M + +V+LPKF +L E LK++GI +FD + N A I+ + + + Sbjct: 359 VERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFDKN-GNMAGIS--DQRIAI 415 Query: 337 SHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQIN 396 + I V+E+GT+A+ TT + S+ F VDRPFLF I + T +LFMG++ Sbjct: 416 DLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFLFLIYEHRTSCLLFMGRVA 475 Query: 397 KP 398 P Sbjct: 476 NP 477 >2H4P-A nrPDB Length = 394 Score = 143 bits (361), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 106/385 (27%), Positives = 185/385 (48%), Gaps = 52/385 (13%) Query: 20 SHFNPLSLEELGSNTG---IQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQ 76 SH +S+E++ ++ G + +FN++ ++ NI SP I+S L + L A G T ++ Sbjct: 19 SHELEISMEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTARE 78 Query: 77 LAMVMRYGV---------------------------------NGVGKILKKINKAIVSKK 103 +A V+ + +G ++L NK + Sbjct: 79 MAEVLHFTEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKP----R 134 Query: 104 NKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFED-PASACDSINAWVKNETR 162 N + AN ++V+ + ++ +K ++ E + VNF+ P + IN WV+ +T Sbjct: 135 NNYSLRSANRIYVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTE 194 Query: 163 DMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQ 222 I NLLS D + TRL+LVNA+YFK W+ +FQ E T + F + KS V M+ Sbjct: 195 SKIKNLLSSDDVKAT-TRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYM 253 Query: 223 LSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALP---TESSTPLSAIIPHISTKTIDS 279 F N + IELPY +SM I LP + +T L + ++ + + Sbjct: 254 RDTFPVLIMEKMN---FKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSE 310 Query: 280 WMS--IMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVS 337 W +M V + LPKF+ + DL++ L+ +G+T F ++ A+F + T ++L +S Sbjct: 311 WADSKMMTETLVDLHLPKFSLEDRIDLRDTLRNMGMTTAF-TTNADFRGM-TDKKDLAIS 368 Query: 338 HILQKAKIEVSEDGTKASAATTAIL 362 ++ ++ + V E GT+A+AAT I+ Sbjct: 369 KVIHQSFVAVDEKGTEAAAATAVII 393 >1HLE-A nrPDB Length = 345 Score = 142 bits (357), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 96/321 (29%), Positives = 158/321 (49%), Gaps = 12/321 (3%) Query: 35 GIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYG-VNGVGKILK 93 + +F + +S P NI ISP I+S L M+ LG G T Q++ + + V + + Sbjct: 13 AVDLFRALNESDPTGNIFISPLSISSALAMIFLGTRGNTAAQVSKALYFDTVEDIHSRFQ 72 Query: 94 KINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFED-PASACDS 152 +N I I+ +AN ++ + F+ + ++ E+ +V+F+ P A Sbjct: 73 SLNADINKPGAPYILKLANRLYGEKTYNFLADFLASTQKMYGAELASVDFQQAPEDARKE 132 Query: 153 INAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADG 212 IN WVK +T I LL ++D +T+LVLVNA+YFKG W+ +F E T+ F Sbjct: 133 INEWVKGQTEGKIPELLVKGMVDN-MTKLVLVNAIYFKGNWQQKFMKEATRDAPFRLNKK 191 Query: 213 KSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALP---TESSTPLSAII 269 + V M+ Q F DL +ELPY G+ +SM+I LP + ST L I Sbjct: 192 DTKTVKMMYQKKKFPYNYIE---DLKCRVLELPYQGKELSMIILLPDDIEDESTGLEKIE 248 Query: 270 PHISTKTIDSWM--SIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKI 327 ++ + W + V V LP+F DL L LG+ D+F+ KA+ + + Sbjct: 249 KQLTLDKLREWTKPENLYLAEVNVHLPRFKLEESYDLTSHLARLGVQDLFNRGKADLSGM 308 Query: 328 TTGSENLHVSHILQKAKIEVS 348 +G+ +L VS I+ K+ ++++ Sbjct: 309 -SGARDLFVSKIIHKSFVDLN 328 >5HGC-A nrPDB Length = 380 Score = 141 bits (355), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 104/382 (27%), Positives = 185/382 (48%), Gaps = 36/382 (9%) Query: 32 SNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKI 91 ++ Q F ++ + P+ NI SP I++ ML LGA T+ Q+ + G+ Sbjct: 16 ADFAFQFFREVTQEAPNKNIFYSPVSISTAFAMLALGARSATQSQI-------LEGLAFN 68 Query: 92 LKKINKAIVSKKNKDIV------------TVANAVFVKNASEIEVPFVTRNKDVFQCEVR 139 L +I + + + +++ + NA+FV A + F+ K ++Q E Sbjct: 69 LTEIQEKEIHEGFHNLIHMLNHPEGGVQLNMMNAIFVTAALALLRKFLDDAKALYQLEAF 128 Query: 140 NVNFEDPASACDSINAWVKNETRDMIDNL---LSPDLIDGVLTRLVLVNAVYFKGLWKSR 196 +F P A IN +++ +T I NL + P T ++L + VYFKG W+ Sbjct: 129 TTDFNKPTEAEKQINDYIERKTHGKITNLVKDMDPQ------TVMLLASFVYFKGSWEKP 182 Query: 197 FQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIA 256 F+ E+T++R F + +VPM+ Q+ F +L + L Y+G + + L+ Sbjct: 183 FEAEHTEEREFFVDAETTVKVPMMYQMGRFDF---YFDEELSCTVVRLHYNGSATAFLV- 238 Query: 257 LPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDM 316 LP + + + + +TI W + + + + PKF+ ++ L+ +GI D+ Sbjct: 239 LPAKGK--MKQLEQTLDKETIQKWSDHLFQRFMNLYFPKFSISGSYEISNTLRKMGIVDV 296 Query: 317 FDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRP 376 F +++A+ + IT GS +L VS ++ KA ++V E GT+A+AAT ++ S PP P Sbjct: 297 F-TNQADLSGIT-GSPDLKVSKVVHKASLDVDEKGTEAAAATAVEIMPISFPPTIEFSHP 354 Query: 377 FLFFIRHNPTGAVLFMGQINKP 398 FL I T + LF+G+I P Sbjct: 355 FLMLIFDRDTNSTLFIGKIVNP 376 >1YXA-A nrPDB Length = 398 Score = 141 bits (355), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 112/396 (28%), Positives = 203/396 (51%), Gaps = 35/396 (8%) Query: 20 SHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAM 79 + + L+L + ++ ++ ++V P NIV SP I++ L ++ LGA G T +++ Sbjct: 20 TQLDSLTLASINTDFAFSLYKELVLKNPDTNIVFSPLSISAALALVSLGAKGNTLEEILE 79 Query: 80 VMRYGV---------NGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRN 130 +++ + G G +L+++N+ K++ ++ +A+F++ +I F + Sbjct: 80 GLKFNLTETSEADIHQGFGHLLQRLNQP----KDQVQISTGSALFIEKRQQILTEFQEKA 135 Query: 131 KDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFK 190 K ++Q E +F+ P A IN +V+ +T+ MI L+S DL L +VLVN +YFK Sbjct: 136 KTLYQAEAFTADFQQPRQAKKLINDYVRKQTQGMIKELVS-DLDKRTL--MVLVNYIYFK 192 Query: 191 GLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSV----FRCGSTSAPNDLWYNFIELPY 246 WK F P +T K F + VPM++ + FR +L +EL Y Sbjct: 193 AKWKVPFDPLDTFKSEFYCGKRRPVIVPMMSMEDLTTPYFR------DEELSCTVVELKY 246 Query: 247 HGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRV-QVILPKFTAVAQTDLK 305 G + S L LP + + + + +T+ W + + P+ + ++ LPKF+ L+ Sbjct: 247 TGNA-SALFILPDQGR--MQQVEASLQPETLRKWKNSLKPRMIDELHLPKFSISTDYSLE 303 Query: 306 EPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILI-- 363 + L LGI ++F S++A+ + I TG+++L VS ++ KA ++V+E GT+A+AAT + Sbjct: 304 DVLSKLGIREVF-STQADLSAI-TGTKDLRVSQVVHKAVLDVAETGTEAAAATGVKFVPM 361 Query: 364 -ARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINKP 398 A+ P +RPFL I T F+ +I P Sbjct: 362 SAKLYPLTVYFNRPFLIMIFDTETEIAPFIAKIANP 397 >6HGE-B nrPDB Length = 409 Score = 138 bits (347), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 111/382 (29%), Positives = 195/382 (51%), Gaps = 36/382 (9%) Query: 35 GIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGK---- 90 ++ Q+V P N++ SP I++ L L LGA T ++ +++ + + Sbjct: 43 AFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTETSEAEIH 102 Query: 91 -----ILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFED 145 +L+ +N++ ++ +++ NA+FVK + F K ++ E +F+D Sbjct: 103 QSFQHLLRTLNQS----SDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQD 158 Query: 146 PASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKR 205 A+A IN +VKN TR I +L+ DL T +VLVN ++FK W+ F P++T + Sbjct: 159 SAAAKKLINDYVKNGTRGKITDLI-KDL--DSQTMMVLVNYIFFKAKWEMPFDPQDTHQS 215 Query: 206 TFVAADGKSYQVPMLA--QLSV--FRCGSTSAPNDLWYNFIELPYHGESISMLIALPTES 261 F + K VPM++ L++ FR +L ++L Y G + S L LP + Sbjct: 216 RFYLSKKKWVMVPMMSLHHLTIPYFR------DEELSCTVVQLNYTGNA-SALFILPDQD 268 Query: 262 STPLSAIIPHISTKTIDSWMSIMVPKRV-QVILPKFTAVAQTDLKEPLKVLGITDMFDSS 320 + + +S +T++ W + + + ++ LPKF+ +L + L LGI + F +S Sbjct: 269 --KMEEVEAMLSRETLNRWGDSLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAF-TS 325 Query: 321 KANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTA--ILIARSSPPWFIV--DRP 376 KA+ + I TG+ NL VS ++ KA ++V E+GT+ASAAT L++ IV +RP Sbjct: 326 KADLSGI-TGARNLAVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTIVRFNRP 384 Query: 377 FLFFIRHNPTGAVLFMGQINKP 398 FL I + T ++ FM ++ P Sbjct: 385 FLMIIVDHFTWSIFFMSKVTNP 406 >5NCU-A nrPDB Length = 336 Score = 137 bits (346), Expect = 6e-33, Method: Compositional matrix adjust. Identities = 98/347 (28%), Positives = 178/347 (51%), Gaps = 21/347 (6%) Query: 24 PLSLEELGSNTGIQVFNQIVKSRPH---DNIVISPHGIASVLGMLQLGADGRTKKQLAMV 80 PL E++ + F+ + +R H N+ ISP ++ L M GA G T ++ Sbjct: 2 PLGSEKIEKDNAF-AFDLLQTTRKHVTEANVFISPLSVSMALNMTLNGAAGVTADEMKTA 60 Query: 81 MR---YGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCE 137 +R Y + + + + +A++ + +AN+++ K ++ PF+ N+ + E Sbjct: 61 LRETGYTMEDINEYSHSLREALLKVDPSTTIGMANSIWYKQGELVKEPFILANRTHYDAE 120 Query: 138 VRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRF 197 V+ V+F PA+ +IN W +T D I +L D I G + L+NAVYFKG+W ++F Sbjct: 121 VKAVDFSSPAT-LPAINGWCAQKTNDKITKIL--DYIPGN-AFMYLINAVYFKGIWVTQF 176 Query: 198 QPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIAL 257 + +TK+ F ADG + +V M+AQ S F G T+ D ++E+ Y ++ SM++ L Sbjct: 177 KKSDTKRAPFRKADGTTQEVNMMAQKSTF--GYTT---DECCQYLEMDYGNKAFSMIVML 231 Query: 258 PTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDL-KEPLKVLGITDM 316 P E T +I + K + + P +V + +P+F + L K+ L +G+ Sbjct: 232 PNEGQTTRD-VIEQLDNKHWSMIIKGIRPTQVSLRMPRFKTECKYGLEKKILPEMGMNVP 290 Query: 317 FDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILI 363 F + A+F IT + + +S ++ K ++V E+GT+A+A T ++ Sbjct: 291 F-TETADFPGITDAA--IFISRVIHKTFVQVDEEGTEAAAVTAVEMV 334 >1XQJ-A nrPDB Length = 389 Score = 137 bits (344), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 90/371 (24%), Positives = 181/371 (48%), Gaps = 14/371 (3%) Query: 35 GIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRY-GVNGVGKILK 93 + +F Q+ + P N++ SP +++ L + Q+GA G T ++ V+ + V V + Sbjct: 26 AVDLFKQLSEKEPLGNVLFSPIALSTSLSLAQVGAKGDTANEIGQVLHFENVKDVPFGFQ 85 Query: 94 KINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACD-S 152 + + + + + ++V + + F++ K + E+ V+F+D Sbjct: 86 TVTSDVNKLSSFYSLKLIKRLYVDKSLNLSTEFISSTKRPYAKELETVDFKDKLEETKGQ 145 Query: 153 INAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADG 212 IN +K+ T +N+L+ + ++ T++++VNA YF G W +F TK+ F Sbjct: 146 INNSIKDLTDGHFENILADNSVNDQ-TKILVVNAAYFVGKWMKKFSESETKESPFRVNKT 204 Query: 213 KSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALP---TESSTPLSAII 269 + V M+ + F G+ + N IELP+ + +SM I LP + ST L I Sbjct: 205 DTKPVQMMNMEATFSMGNIDSINS---KIIELPFQNKHLSMFILLPKDVEDESTGLEKIE 261 Query: 270 PHISTKTIDSWM--SIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKI 327 ++++++ W S M +V++ +PKF D K L+ LG+ +F ++F+ + Sbjct: 262 KQLNSESLSQWTNPSTMANAKVKLSIPKFKVEKMIDPKASLENLGLKHIFSEDTSDFSGM 321 Query: 328 TTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPTG 387 + ++ + +S+++ K +E++EDG + A ++ D PF++ IRHN T Sbjct: 322 SE-TKGVALSNVIHKVSLEITEDGGDSIEVPGARILQHKDE--LNADHPFIYIIRHNKTR 378 Query: 388 AVLFMGQINKP 398 ++F G+ + P Sbjct: 379 NIIFFGKFSSP 389 >3PZF-A nrPDB Length = 397 Score = 136 bits (342), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 97/363 (26%), Positives = 173/363 (47%), Gaps = 21/363 (5%) Query: 50 NIVISPHGIASVLGMLQLGAD-------GRTKKQLAMVMRY-GVNGVGKILKKINKAIVS 101 N+V+SP + +L ++ +D TK++L+ V++ ++ K++ ++ Sbjct: 40 NVVLSPFSVKILLTLIYEASDTSFGNAVSNTKRELSSVIQNDNIDHTRSYYKQLLES-AQ 98 Query: 102 KKNKDI-VTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNE 160 + NKD + +A FV + E+ + + + V++ +P +IN WV Sbjct: 99 QDNKDYDLNIATNFFVDDFIEVINKYQQIANTHYHAMLEKVSYSNPTQTAATINNWVSEH 158 Query: 161 TRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPML 220 T + +++PD ++G + + LVN +YFKGLW F + F GK + Sbjct: 159 TNGRLREIVTPDSLEGAV--ITLVNVIYFKGLWTYPFPEVANNVKPFYGTRGKPTNAQYM 216 Query: 221 AQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDSW 280 Q F +++ DL + LPY G ++M LP +T ++ ++ I++ ++ Sbjct: 217 EQNGQFYYDNSA---DLGAQILRLPYRGNKLAMYFILPNPDNT-VNQVLDRINSASLHQA 272 Query: 281 MSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMF--DSSKANFAKITTGSENLHVSH 338 + M V V LPKF L EPL+ +GI ++F ++S A+ + + VS Sbjct: 273 LWYMEENEVNVTLPKFKFDFSEQLNEPLQQVGIREIFSQNASLPLLARGRGARDEVRVSR 332 Query: 339 ILQKAKIEVSEDGTKASAATTAILIAR---SSPPWFIVDRPFLFFIRHNPTGAVLFMGQI 395 I QKA I ++E G++A AAT L+ + F +RPF+FFI G +LF G+I Sbjct: 333 IFQKAGITINELGSEAYAATEIQLVNKFGGDGVQIFNANRPFIFFIEDETLGTMLFAGKI 392 Query: 396 NKP 398 P Sbjct: 393 ENP 395 >3STO-A nrPDB Length = 406 Score = 135 bits (339), Expect = 4e-32, Method: Compositional matrix adjust. Identities = 96/355 (27%), Positives = 169/355 (47%), Gaps = 28/355 (7%) Query: 49 DNIVISPHGIASVLGML--QLGADGRTKKQLAMVMRY-----------GVNGVGKILKKI 95 DN + P GI LG+L GA GRT Q+ MR + + +++ Sbjct: 37 DNFLTCPLGILFTLGILLGSGGAQGRTGYQIGKTMRLKSTSSSWNSSEAQQEMKSLYQEL 96 Query: 96 NKAIVSKK------NKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASA 149 N ++ S+K +++V ++ +FV+ E+E F + + E++ V+F + SA Sbjct: 97 NNSLTSEKTFLNEKEENVVRISTGIFVEKTYEVERRFNESIANDSEGELKQVDFSNRTSA 156 Query: 150 CDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVA 209 IN WV ++ +++ + D+ D T ++LVN YF+ W+S F+P T+K F Sbjct: 157 TVDINDWVDQQSNGLLEKFFTDDIPDD--TAMILVNVFYFRDFWQSPFEPHYTRKEDFYI 214 Query: 210 ADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAII 269 + + V M+ Q V + G D + + P + + +I LP E + A Sbjct: 215 SPDRQITVDMMTQEGVMKYGKFE---DEGFEIVSKPLNNTRFTFVIVLPLEKWSLNGATE 271 Query: 270 PHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITT 329 K + ++ + V + LPKFT DL LK +G+ D+FD K++ + IT Sbjct: 272 LLNGNKVLSEYVKNLKETTVSLRLPKFTLKNTLDLVPTLKSIGVVDLFDPVKSDLSGITP 331 Query: 330 GSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSS--PPW-FIVDRPFLFFI 381 + NL+V+ +Q ++++E G +A+ T+ I + S+ P F V PF+ FI Sbjct: 332 -NPNLYVNEFIQTNVLKLNESGIEATTVTSPIFVPFSAIIPEVDFHVTHPFICFI 385 >3OZQ-A nrPDB Length = 376 Score = 134 bits (337), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 110/375 (29%), Positives = 191/375 (50%), Gaps = 41/375 (10%) Query: 38 VFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINK 97 V+ +++K+ N ++SP A++L + Q G G T +++ V+ + G + + K Sbjct: 22 VYKEVLKTEKA-NFLVSPFSAATLLALAQSGCRGDTAEEIRQVLHFV--GDREKAEGAVK 78 Query: 98 AIVSKKNKDIVTV--ANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINA 155 ++SK + T+ AN ++VK + F +V+ + NV+F + A +NA Sbjct: 79 EVLSKLTNEEYTLHTANKIYVKTNFSVREEFQKIAVEVYGAQSENVDFSEKNDAAKLMNA 138 Query: 156 WVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSY 215 WV+ +T+ I NL+ P++++ LTR+VL+NA+YF W F P +T+K F + + Sbjct: 139 WVEEQTQHKIQNLVDPEILNN-LTRVVLINALYFNAKWLVPFPPFHTRKSDFHKSAKEVV 197 Query: 216 QVPML----AQLSVFRCGSTSAPNDLWYNFIELPYH-GESISMLIALPTESSTPLS---- 266 QV + + + C A +ELP+ G S++++++ E L Sbjct: 198 QVDTMYLDEQYFNYYECHHLDA------KLLELPFKGGASLTIVLSNQIEGLVSLESKIK 251 Query: 267 -AIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFA 325 + +PH TK + V V LPKF + D K+ LK LG+ F +A+ + Sbjct: 252 RSFLPHNLTKQL-----------VNVALPKFKIESTVDFKKVLKKLGVKKAF-GDEADLS 299 Query: 326 KITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARS-----SPPWFIVDRPFLFF 380 I +L +S+I+QK+ I+VSE+G +A+AAT +I SP FIVD PF+F+ Sbjct: 300 GIAGEKGDLVISNIVQKSFIDVSEEGVEAAAATYIPVILPEMALPDSPKQFIVDHPFIFY 359 Query: 381 IRHNPTGAVLFMGQI 395 I+ G +LF G++ Sbjct: 360 IK--VKGMILFAGRV 372 >4Y40-A nrPDB Length = 414 Score = 130 bits (328), Expect = 7e-31, Method: Compositional matrix adjust. Identities = 92/373 (24%), Positives = 180/373 (48%), Gaps = 22/373 (5%) Query: 33 NTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKIL 92 + G ++ ++ P NI +SP I++ ML LGA T ++ + G N Sbjct: 54 DLGFKLLKKLAFYNPGRNIFLSPLSISTAFSMLCLGAQDSTLDEI----KQGFNFRKMPE 109 Query: 93 KKINKAI------VSKKNKDI-VTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFED 145 K +++ +++K +D+ +++ N +F+ + + F+ K+ + E NF++ Sbjct: 110 KDLHEGFHYIIHELTQKTQDLKLSIGNTLFIDQRLQPQRKFLEDAKNFYSAETILTNFQN 169 Query: 146 PASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKR 205 A IN ++ +T I+NL+ ++ G T ++L N ++F+ WK F P TK+ Sbjct: 170 LEMAQKQINDFISQKTHGKINNLIE-NIDPG--TVMLLANYIFFRARWKHEFDPNVTKEE 226 Query: 206 TFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPL 265 F S +VPM+ + +++ G + L +E+PY ++I+ + LP E L Sbjct: 227 DFFLEKNSSVKVPMMFRSGIYQVGYD---DKLSCTILEIPYQ-KNITAIFILPDEGK--L 280 Query: 266 SAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFA 325 + + T W +++ + V V +P+ DLK+ L +G++ +F+ + Sbjct: 281 KHLEKGLQVDTFSRWKTLLSRRVVCVSVPRLHMTGTFDLKKTLSYIGVSKIFEEH-GDLT 339 Query: 326 KITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNP 385 KI +L V + KA++++ E GT+ +A T A + +P +D+P+L I Sbjct: 340 KIAP-HRSLKVGEAVHKAELKMDERGTEGAAGTGAQTLPMETPLCVKIDKPYLLLIYSEK 398 Query: 386 TGAVLFMGQINKP 398 +VLF+G+I P Sbjct: 399 IPSVLFLGKIVNP 411 >3DY0-A nrPDB Length = 336 Score = 129 bits (324), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 91/336 (27%), Positives = 173/336 (51%), Gaps = 28/336 (8%) Query: 38 VFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVN----------- 86 ++ + + P NI SP I+ L ML LGA TK Q+ + G+N Sbjct: 16 LYRALASAAPSQNIFFSPVSISMSLAMLSLGAGSSTKMQILEGL--GLNLQKSSEKELHR 73 Query: 87 GVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDP 146 G ++L+++N+ ++ +++ NA+F +++ FV+ K ++ + NF D Sbjct: 74 GFQQLLQELNQP----RDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDS 129 Query: 147 ASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRT 206 A A IN +V +T+ I +LL + V+ ++VN ++FK W++ F + T+++ Sbjct: 130 AGAMKQINDYVAKQTKGKIVDLLKNLDSNAVV---IMVNYIFFKAKWETSFNHKGTQEQD 186 Query: 207 FVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLS 266 F +VPM+++ + +L + +PY G + ++ I LP+E + Sbjct: 187 FYVTSETVVRVPMMSREDQYHY---LLDRNLSCRVVGVPYQGNATALFI-LPSEG--KMQ 240 Query: 267 AIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAK 326 + +S KT+ W+ + +++++ LPKF+ L++ L LGI+++F +S A+ + Sbjct: 241 QVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVF-TSHADLSG 299 Query: 327 ITTGSENLHVSHILQKAKIEVSEDGTKASAATTAIL 362 I+ S N+ VS ++ KA +EV E GT+A+AAT I Sbjct: 300 ISNHS-NIQVSEMVHKAVVEVDESGTRAAAATGTIF 334 >3ZHA-A nrPDB Length = 392 Score = 128 bits (322), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 91/382 (23%), Positives = 174/382 (45%), Gaps = 23/382 (6%) Query: 26 SLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGV 85 +L E + ++ + K + +NI++SP +AS LG++ LG T Q V+ Sbjct: 8 TLAERSAGLAFSLYQAMAKDQAVENILLSPVVVASSLGLVSLGGKATTASQAKAVLSAEQ 67 Query: 86 -------NGVGKILKKINKAIVSKKNKDIV-TVANAVFVKNASEIEVPFVTRNKDVFQCE 137 G+G++L+ ++ + +++ + + ++ ++ FV +K + CE Sbjct: 68 LRDEEVHAGLGELLRSLSNSTA----RNVTWKLGSRLYGPSSVSFAEDFVRSSKQHYNCE 123 Query: 138 VRNVNFEDPASACDSINAWVKNETRDMIDNLLSP-DLIDGVLTRLVLVNAVYFKGLWKSR 196 +NF D SA SIN W T + + + DG L LVNA++FK W + Sbjct: 124 HSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGAL----LVNAMFFKPHWDEK 179 Query: 197 FQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIA 256 F + R F+ + V M+ + ++ +E+P + S++I Sbjct: 180 FHHKMVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEK---LQIVEMPLAHKLSSLIIL 236 Query: 257 LPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDM 316 +P PL + ++ + + WM M K V + LPK DL++ L LG+T+ Sbjct: 237 MP-HHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEA 295 Query: 317 FDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRP 376 D +KA+ +++ +G ++L+++ + E +G R SP F D P Sbjct: 296 IDKNKADLSRM-SGKKDLYLASVFHATAFEWDTEGNPFDQDIYGREELR-SPKLFYADHP 353 Query: 377 FLFFIRHNPTGAVLFMGQINKP 398 F+F +R +G++LF+G++ +P Sbjct: 354 FIFLVRDTQSGSLLFIGRLVRP 375 >4AJU-A nrPDB Length = 387 Score = 126 bits (316), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 97/342 (28%), Positives = 173/342 (50%), Gaps = 21/342 (6%) Query: 32 SNTGIQVFNQIVKSRPHD-NIVISPHGIASVLGMLQLGADGRTKKQLA-----MVMRYGV 85 SN G + +I S HD N+V SP G++ + L LGA G T+ Q+ ++ Sbjct: 59 SNFGFSLLRKI--SMRHDGNMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHLQALKPTK 116 Query: 86 NGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFED 145 G+ L K + +S+ + +T + F+ +++ F +K F E +NF + Sbjct: 117 PGLLPSLFKGLRETLSRNLELGLTQGSFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRN 176 Query: 146 PASACDSINAWVKNETRDMIDNLLSPDLIDGV--LTRLVLVNAVYFKGLWKSRFQPENTK 203 + A +N ++ ETR I P L D + T+L+LV+ + FKG W + F P T+ Sbjct: 177 ASQAKRLMNHYINKETRGKI-----PKLFDEINPETKLILVDYILFKGKWLTPFDPVFTE 231 Query: 204 KRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESST 263 TF K+ +VPM+ F +++ + + ++LPY G + +ML+ L + Sbjct: 232 VDTFHLDKYKTIKVPMMYGAGKF---ASTFDKNFRCHVLKLPYQGNA-TMLVVLMEKMGD 287 Query: 264 PLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKAN 323 L A+ +++T +++W+ M + ++V PKF + ++ E L+ +GI +F S A+ Sbjct: 288 HL-ALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRIF-SPFAD 345 Query: 324 FAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIAR 365 ++++ NL VS +LQ+ IEV E GT+A A + + AR Sbjct: 346 LSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAR 387 >6BJ5-B nrPDB Length = 315 Score = 125 bits (314), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 86/313 (27%), Positives = 160/313 (51%), Gaps = 34/313 (10%) Query: 49 DNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIV 108 DN+V SP+G+ S L +L++ A G TK+++ + +++V ++ D Sbjct: 31 DNVVFSPYGLTSALSVLRIAAGGNTKREI----------------DVPESVV--EDSDAF 72 Query: 109 TVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNL 168 +FV + + F F V+ V F + + D IN++VK++T + Sbjct: 73 LALRELFVDASVPLRPEFTAEFSSRFNTSVQRVTF-NSENVKDVINSYVKDKTGGDV--- 128 Query: 169 LSPDLIDGVL---TRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSV 225 P ++D L T+++L+++V K W+ F P T + F + + +Y+V M+ ++ Sbjct: 129 --PRVLDASLDRDTKMLLLSSVRMKTSWRHVFDPSFTTDQPFYSGN-VTYKVRMMNKIDT 185 Query: 226 FRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMV 285 + + + N + Y+ ELPY +ML+ +P + L I+ + + W+ M Sbjct: 186 LKTETFTLRN-VGYSVTELPYKRRQTAMLLVVPDD----LGEIVRALDLSLVRFWIRNMR 240 Query: 286 PKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKI 345 QV++PKF+ + DL++ L+ LG+ D FD S+A+F + + S +L+V+ +LQ +KI Sbjct: 241 KDVCQVVMPKFSVESVLDLRDALQRLGVRDAFDPSRADFGQ-ASPSNDLYVTKVLQTSKI 299 Query: 346 EVSEDGTKASAAT 358 E E GT AS+ T Sbjct: 300 EADERGTTASSDT 312 >2V95-A nrPDB Length = 371 Score = 123 bits (309), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 95/375 (25%), Positives = 178/375 (47%), Gaps = 32/375 (8%) Query: 35 GIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKK 94 ++ ++V P N +ISP I+ L M+ LG+ +T+ ++ +I + Sbjct: 17 AFNLYQRLVALNPDKNTLISPVSISMALAMVSLGS-AQTQSLQSLGFNLTETSEAEIHQS 75 Query: 95 INKAIVSKKNKDI---VTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACD 151 K D + + NA+F+ +++ F+ K ++ E ++FED A Sbjct: 76 FQYLNYLLKQSDTGLEMNMGNAMFLLQKLKLKDSFLADVKQYYESEALAIDFEDWTKASQ 135 Query: 152 SINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAAD 211 IN VK++T+ I+++ S +D + +LVN ++ +G+W+ F PENT++ F + Sbjct: 136 QINQHVKDKTQGKIEHVFSD--LDSPAS-FILVNYIFLRGIWELPFSPENTREEDFYVNE 192 Query: 212 GKSYQVPMLAQL--------SVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESST 263 + +VPM+ Q SVF C I++ Y G + I LP + Sbjct: 193 TSTVKVPMMVQSGSIGYFRDSVFPC-----------QLIQMDYVGNGTAFFI-LPDQGQ- 239 Query: 264 PLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKAN 323 + +I +S TID W +M P++V + +PKF+ DLK+ L+ L I D+ +++++ Sbjct: 240 -MDTVIAALSRDTIDRWGKLMTPRQVNLYIPKFSMSDTYDLKDVLEDLNIKDLL-TNQSD 297 Query: 324 FAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRH 383 F+ T L ++ ++ KA +++ E ++ A L RS P ++PF+ + Sbjct: 298 FSG-NTKDVPLTLT-MVHKAMLQLDEGNVLPNSTNGAPLHLRSEPLDIKFNKPFILLLFD 355 Query: 384 NPTGAVLFMGQINKP 398 T + L M Q+ P Sbjct: 356 KFTWSSLMMSQVVNP 370 >3LE2-A nrPDB Length = 393 Score = 121 bits (303), Expect = 5e-28, Method: Compositional matrix adjust. Identities = 98/372 (26%), Positives = 173/372 (46%), Gaps = 31/372 (8%) Query: 48 HDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYG-VNGVGKILKKINKAIVSKKNKD 106 + N++ SP I VL ++ G+ G TK Q+ +++ + + +I A+++ + + Sbjct: 30 NSNVIFSPASINVVLSIIAAGSAGATKDQILSFLKFSSTDQLNSFSSEIVSAVLADGSAN 89 Query: 107 ---IVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPA-SACDSINAWVKNETR 162 ++VAN ++ + + F +D ++ +F+ A +N+W + ET Sbjct: 90 GGPKLSVANGAWIDKSLSFKPSFKQLLEDSYKAASNQADFQSKAVEVIAEVNSWAEKETN 149 Query: 163 DMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQ 222 +I +L P+ +T+L+ NA+YFKG W +F T++ F DG P + Sbjct: 150 GLITEVL-PEGSADSMTKLIFANALYFKGTWNEKFDESLTQEGEFHLLDGNKVTAPFMTS 208 Query: 223 LSVFRCGSTSAPNDLWYNFIELPY-HGE---SISMLIALPTESSTPLSAIIPHISTKTID 278 + + + LPY G+ SM LP +++ LS ++ I + Sbjct: 209 KKKQYVSAYDG-----FKVLGLPYLQGQDKRQFSMYFYLP-DANNGLSDLLDKIVSTP-- 260 Query: 279 SWMSIMVPKRV----QVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSE-- 332 ++ +P+R + +PKF D LK LG+T F S + ++ E Sbjct: 261 GFLDNHIPRRQVKVREFKIPKFKFSFGFDASNVLKGLGLTSPF-SGEEGLTEMVESPEMG 319 Query: 333 -NLHVSHILQKAKIEVSEDGTKASAATTAI-----LIARSSPPWFIVDRPFLFFIRHNPT 386 NL VS+I KA IEV+E+GT+A+AA+ + L+ F+ D PFL + N T Sbjct: 320 KNLCVSNIFHKACIEVNEEGTEAAAASAGVIKLRGLLMEEDEIDFVADHPFLLVVTENIT 379 Query: 387 GAVLFMGQINKP 398 G VLF+GQ+ P Sbjct: 380 GVVLFIGQVVDP 391 >2R9Y-A nrPDB Length = 430 Score = 117 bits (292), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 94/362 (25%), Positives = 171/362 (47%), Gaps = 19/362 (5%) Query: 38 VFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINK 97 +F+ + ++ N+V+SP +A L L LGA +T L V+ G L + Sbjct: 32 LFSLVAQTSTSSNLVLSPLSVALALSHLALGAQNQTLHSLHRVLHMNT---GSCLPHLLS 88 Query: 98 AIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWV 157 + +A ++++ I+ F+ +++ +F + + + + IN WV Sbjct: 89 HFYQNLGPGTIRLAARIYLQKGFPIKDDFLEQSERLFGAKPVKLTGKQEEDLAN-INQWV 147 Query: 158 KNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQV 217 K T I++ LS +L D T L+L+NA++F G W+++F P T+K F + + V Sbjct: 148 KEATEGKIEDFLS-ELPDS--TVLLLLNAIHFHGFWRTKFDPSLTQKDFFHLDERFTVSV 204 Query: 218 PMLAQLSV-FRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKT 276 M+ +S R P P+ ++S ++ +PT +S ++ +++ T Sbjct: 205 DMMHAVSYPLRWFLLEQPE---IQVAHFPFKN-NMSFVVVMPTYFEWNVSEVLANLTWDT 260 Query: 277 IDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHV 336 + + + + +V LPK Q DL L LG+ ++F +NL V Sbjct: 261 L--YHPSLQERPTKVWLPKLHLQQQLDLVATLSQLGLQELFQGPDLR----GISEQNLVV 314 Query: 337 SHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQIN 396 S + ++ +E+SE G +A+AAT+ + + R S F V+RPFLFFI + G LF+G + Sbjct: 315 SSVQHQSTMELSEAGVEAAAATS-VAMNRMSLSSFTVNRPFLFFIMEDTIGVPLFVGSVR 373 Query: 397 KP 398 P Sbjct: 374 NP 375 >3NE4-A nrPDB Length = 424 Score = 115 bits (289), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 96/373 (25%), Positives = 171/373 (45%), Gaps = 30/373 (8%) Query: 38 VFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGV---------NGV 88 ++ Q+ NI SP IA+ ML LG T ++ + + + G Sbjct: 67 LYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGF 126 Query: 89 GKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPAS 148 ++L+ +N+ ++ +T N +F+ ++ F+ K ++ E VNF D Sbjct: 127 QELLRTLNQP----DSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEE 182 Query: 149 ACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFV 208 A IN +V+ T+ I +L+ D V LVN ++FKG W+ F+ ++T++ F Sbjct: 183 AKKQINDYVEKGTQGKIVDLVKELDRDTVF---ALVNYIFFKGKWERPFEVKDTEEEDFH 239 Query: 209 AADGKSYQVPMLAQLSVF---RCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPL 265 + +VPM+ +L +F C S+ W + + Y G + ++ LP E L Sbjct: 240 VDQVTTVKVPMMKRLGMFNIQHCKKLSS----WV--LLMKYLGNATAIFF-LPDEGK--L 290 Query: 266 SAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFA 325 + ++ I ++ + + LPK + DLK L LGIT +F S+ A+ + Sbjct: 291 QHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVF-SNGADLS 349 Query: 326 KITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNP 385 +T + L +S + KA + + E GT+A+ A I S PP ++PF+F + Sbjct: 350 GVTEEAP-LKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPMSIPPEVKFNKPFVFLMIEQN 408 Query: 386 TGAVLFMGQINKP 398 T + LFMG++ P Sbjct: 409 TKSPLFMGKVVNP 421 >1C8O-A nrPDB Length = 300 Score = 107 bits (266), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 93/334 (27%), Positives = 169/334 (50%), Gaps = 42/334 (12%) Query: 36 IQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKI 95 + +F +I S +N+ ISP I+SVL +L GA+G T +QL+ K + Sbjct: 1 MDIFREIASSMKGENVFISPPSISSVLTILYYGANGSTAEQLS--------------KYV 46 Query: 96 NKAIVSKKNKDIVTVA--NAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSI 153 K + KNKD ++ N V+ + ++ + F+ + D FQ V+F D + D+I Sbjct: 47 EKE--ADKNKDDISFKSMNKVYGRYSAVFKDSFLRKIGDNFQT----VDFTD-SRTVDAI 99 Query: 154 NA----WVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVA 209 N + + + ++D LSPD T L+ ++AVYFK W F+ E T F Sbjct: 100 NKSVDIFTEGKINPLLDEPLSPD------TSLLAISAVYFKAKWLMPFEKEFTSDYPFYV 153 Query: 210 ADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNF--IELPYHGESISMLIALPTESSTPLSA 267 + + V M++ + ++ + + NF IELPY G++ SM++ LP ++ L + Sbjct: 154 SPTEMVDVSMMSMYG--EAFNHASVKESFGNFSIIELPYVGDT-SMVVILP-DNIDGLES 209 Query: 268 IIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKI 327 I +++ W M + V +PKF +L + L LG+T++F S+ +++ + Sbjct: 210 IEQNLTDTNFKKWSDSMDAMFIDVHIPKFKVTGSYNLVDALVKLGLTEVFGST-GDYSNM 268 Query: 328 TTGSENLHVSHILQKAKIEVSEDGTKASAATTAI 361 + ++ V ++ K I+V+E+ T+A+AAT+A+ Sbjct: 269 SNS--DVSVDAMIHKTYIDVNEEYTEAAAATSAL 300 >2PEF-A nrPDB Length = 373 Score = 105 bits (261), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 99/371 (26%), Positives = 173/371 (46%), Gaps = 28/371 (7%) Query: 35 GIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQL--AMVMRYGVNGVGKIL 92 I++F + + +N +ISP L M GAD T Q+ A+ + + K L Sbjct: 17 SIELFKNSIDDK--ENSLISPLSAMLALAMTANGADNETLAQMEKALGKDISIEDLNKYL 74 Query: 93 KKINKAIVSKKNKDIVTVANAV-FVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACD 151 K + +++ K +T+AN++ F +N F+ D ++ ++ F+ +S Sbjct: 75 YTYMKKLPNEE-KSKLTIANSIWFKENDFMPSKDFLQIIADYYKADIFKAAFD--SSTVS 131 Query: 152 SINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAAD 211 IN WVK++T MID +L+ + V+ L+NAV F W++ ++ + + F Sbjct: 132 DINNWVKSKTNGMIDKILNKIDPEDVM---YLINAVAFDAEWETVYEKASVHEDIFTDVY 188 Query: 212 GKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPH 271 G +V + +A F++ PY S + LP E+ + + + Sbjct: 189 GNRQKVEFMNSEENLYIEEENAVG-----FVK-PYAKNHYSFVAILPDENIS----VNEY 238 Query: 272 ISTKTIDSWMSIMVPKRVQVI---LPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKIT 328 I T T ++ ++ ++ ++ LPKF + E L+ LG+TD F KA+F+K+ Sbjct: 239 IKTLTGQKFIDLIKNAKITLVRASLPKFKYEYTIKMNETLESLGMTDAFLPDKADFSKLG 298 Query: 329 TGS-ENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWF---IVDRPFLFFIRHN 384 NL++S +L K I V E GTKA A T+ + A P F ++RPF+F I N Sbjct: 299 KSDIGNLYISEVLHKTFISVDELGTKAGAVTSVDITAAGIPVNFKTVKLNRPFIFAIIDN 358 Query: 385 PTGAVLFMGQI 395 T +F+G + Sbjct: 359 STNLPIFIGTV 369 >6F02-A nrPDB Length = 389 Score = 102 bits (253), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 103/394 (26%), Positives = 182/394 (46%), Gaps = 52/394 (13%) Query: 32 SNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKI 91 ++ + + I P NI SP I++ ML LGA ++ Q+ + G+G Sbjct: 12 ADFAFRFYYLIASETPGKNIFFSPLSISAAYAMLSLGACSHSRSQI-------LEGLGFN 64 Query: 92 LKKINKAIVSKKNKDIV------------TVANAVFVKNASEIEVPFVTRNKDVFQCEVR 139 L +++++ V + + ++ V +A+F+ + + F+ V++ ++ Sbjct: 65 LTELSESDVHRGFQHLLHTLNLPGHGLETRVGSALFLSHNLKFLAKFLNDTMAVYEAKLF 124 Query: 140 NVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQP 199 + NF D IN VK ETR I +L+S +L VL +VLVN +YFK LW+ F Sbjct: 125 HTNFYDTVGTIQLINDHVKKETRGKIVDLVS-ELKKDVL--MVLVNYIYFKALWEKPFIS 181 Query: 200 ENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWY--------NFIELPYHGESI 251 T + F + + +VPM+ Q WY + + + Y G++ Sbjct: 182 SRTTPKDFYVDENTTVRVPMMLQ----------DQEHHWYLHDRYLPCSVLRMDYKGDAT 231 Query: 252 SMLIALPTESSTPLSAIIPHISTKTIDSWMSIM----VPKRVQVILPKFTAVAQTDLKEP 307 I LP + + I ++ + + W +++ K++++ LPKF+ L + Sbjct: 232 VFFI-LPNQGK--MREIEEVLTPEMLMRWNNLLRKRNFYKKLELHLPKFSISGSYVLDQI 288 Query: 308 LKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATT---AILIA 364 L LG TD+F S A+ + IT + L S KA ++V E GT+A+AAT+ A Sbjct: 289 LPRLGFTDLF-SKWADLSGITK-QQKLEASKSFHKATLDVDEAGTEAAAATSFAIKFFSA 346 Query: 365 RSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINKP 398 +++ +RPFL I T +VLF+G++ P Sbjct: 347 QTNRHILRFNRPFLVVIFSTSTQSVLFLGKVVDP 380 >2XN5-A nrPDB Length = 350 Score = 101 bits (251), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 86/358 (24%), Positives = 169/358 (47%), Gaps = 31/358 (8%) Query: 27 LEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGV- 85 + + ++ ++ + P NI SP I++ L ML GA T+ ++ + + + Sbjct: 11 MSSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLT 70 Query: 86 --------NGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCE 137 +G ++ +N KK ++ + NA+F+ + F+ K +++ E Sbjct: 71 DTPMVEIQHGFQHLICSLN---FPKKELEL-QIGNALFIGKHLKPLAKFLNDVKTLYETE 126 Query: 138 VRNVNFEDPASACDSINAWVKNETRDMIDNL---LSPDLIDGVLTRLVLVNAVYFKGLWK 194 V + +F + ++A IN+ V+ +T+ + L L P+ I +VLVN ++FK W Sbjct: 127 VFSTDFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPNTI------MVLVNYIHFKAQWA 180 Query: 195 SRFQPENTK-KRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISM 253 + F P T+ +F+ + QVPM+ Q+ + +L +++ Y ++++ Sbjct: 181 NPFDPSKTEDSSSFLIDKTTTVQVPMMHQMEQYY---HLVDMELNCTVLQMDYSKNALAL 237 Query: 254 LIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGI 313 + LP E + ++ +S+KT+ W ++ V + +PKF+ A DL L +GI Sbjct: 238 FV-LPKEGQ--MESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGI 294 Query: 314 TDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWF 371 + S A+F+ +T + L +S+ KA + + E GT+A+ A I RS P F Sbjct: 295 QHAY-SENADFSGLTEDN-GLKLSNAAHKAVLHIGEKGTEAAGAMFLEAIPRSIPNTF 350 >1IMV-A nrPDB Length = 398 Score = 99.8 bits (247), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 95/374 (25%), Positives = 176/374 (47%), Gaps = 24/374 (6%) Query: 32 SNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKI 91 SN G ++ P N+++SP +A+ L L LGAD RT+ + + Y + I Sbjct: 39 SNFGYDLYRVRSSMSPTTNVLLSPLSVATALSALSLGADERTESIIHRALYYDLISSPDI 98 Query: 92 LKKINKAI--VSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASA 149 + + V+ K++ + + VF K I+ FV + + R V +P Sbjct: 99 HGTYKELLDTVTAPQKNLKSASRIVFEKKL-RIKSSFVAPLEKSYGTRPR-VLTGNPRLD 156 Query: 150 CDSINAWVKNETRDMIDNLLS--PDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTF 207 IN WV+ + + + PD I ++L+ +FKG W ++F T F Sbjct: 157 LQEINNWVQAQMKGKLARSTKEIPDEIS-----ILLLGVAHFKGQWVTKFDSRKTSLEDF 211 Query: 208 VAADGKSYQVPMLAQ-LSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLS 266 + ++ +VPM++ +V R G S DL +LP G S+S++ LP + + L+ Sbjct: 212 YLDEERTVRVPMMSDPKAVLRYGLDS---DLSCKIAQLPLTG-SMSIIFFLPLKVTQNLT 267 Query: 267 AIIPHISTKTIDSWMSIMVPKRVQVIL--PKFTAVAQTDLKEPLKVLGITDMFDSSKANF 324 I ++++ I + K VQ +L PK + ++ + L+ + + +FDS +F Sbjct: 268 LIEESLTSEFIHDIDREL--KTVQAVLTVPKLKLSYEGEVTKSLQEMKLQSLFDS--PDF 323 Query: 325 AKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHN 384 +KIT + + ++ + +A E +EDG + + + P + +++PF+F +R Sbjct: 324 SKIT--GKPIKLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLTFPLDYHLNQPFIFVLRDT 381 Query: 385 PTGAVLFMGQINKP 398 TGA+LF+G+I P Sbjct: 382 DTGALLFIGKILDP 395 >6F4U-A nrPDB Length = 341 Score = 91.3 bits (225), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 84/340 (24%), Positives = 152/340 (44%), Gaps = 49/340 (14%) Query: 32 SNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKI 91 ++ + + I P NI SP I++ ML LGA ++ Q+ + G+G Sbjct: 10 ADFAFRFYYLIASETPGKNIFFSPLSISAAYAMLSLGACSHSRSQI-------LEGLGFN 62 Query: 92 LKKINKAIVSKKNKDIV------------TVANAVFVKNASEIEVPFVTRNKDVFQCEVR 139 L +++++ V + + ++ V +A+F+ + + F+ V++ ++ Sbjct: 63 LTELSESDVHRGFQHLLHTLNLPGHGLETRVGSALFLSHNLKFLAKFLNDTMAVYEAKLF 122 Query: 140 NVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQP 199 + NF D IN VK ETR I +L+S +L VL +VLVN +YFK LW+ F Sbjct: 123 HTNFYDTVGTIQLINDHVKKETRGKIVDLVS-ELKKDVL--MVLVNYIYFKALWEKPFIS 179 Query: 200 ENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWY--------NFIELPYHGESI 251 T + F + + +VPM+ Q WY + + + Y G++ Sbjct: 180 SRTTPKDFYVDENTTVRVPMMLQ----------DQEHHWYLHDRYLPCSVLRMDYKGDAT 229 Query: 252 SMLIALPTESSTPLSAIIPHISTKTIDSWMSIM----VPKRVQVILPKFTAVAQTDLKEP 307 I LP + + I ++ + + W +++ K++++ LPKF+ L + Sbjct: 230 VFFI-LPNQGK--MREIEEVLTPEMLMRWNNLLRKRNFYKKLELHLPKFSISGSYVLDQI 286 Query: 308 LKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEV 347 L LG TD+F S A+ + IT + L S KA ++V Sbjct: 287 LPRLGFTDLF-SKWADLSGITK-QQKLEASKSFHKATLDV 324 >1QMB-A nrPDB Length = 326 Score = 90.1 bits (222), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 81/323 (25%), Positives = 147/323 (45%), Gaps = 37/323 (11%) Query: 50 NIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGV---------NGVGKILKKINKAIV 100 NI SP IA+ ML LG T ++ + + + G ++L+ +N+ Sbjct: 24 NIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAAIHEGFQELLRTLNQP-- 81 Query: 101 SKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNE 160 ++ +T N +F+ ++ F+ K ++ E VNF D A IN +V+ Sbjct: 82 --DSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKG 139 Query: 161 TRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPML 220 T+ I +L+ D V LVN ++FKG W+ F+ ++T++ F + +VPM+ Sbjct: 140 TQGKIVDLVKELDRDTVF---ALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMM 196 Query: 221 AQLSVF---RCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKTI 277 +L +F C S+ W + + Y G + ++ LP E + H+ + Sbjct: 197 KRLGMFNIQHCKKLSS----WV--LLMKYLGNATAIFF-LPDEGK------LQHLENELT 243 Query: 278 DSWMSIMVP---KRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENL 334 ++ + + + LPK + DLK L LGIT +F S+ A+ + +T + L Sbjct: 244 HDIITKFLENDRRSASLHLPKLSITGTYDLKSVLGQLGITKVF-SNGADLSGVTEEAP-L 301 Query: 335 HVSHILQKAKIEVSEDGTKASAA 357 +S + KA + + E GT+A+ A Sbjct: 302 KLSKAVHKAVLTIDEKGTEAAGA 324 >1M93-B nrPDB Length = 245 Score = 79.3 bits (194), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 69/256 (26%), Positives = 131/256 (51%), Gaps = 24/256 (9%) Query: 112 NAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINA----WVKNETRDMIDN 167 N V+ + ++ + F+ + D FQ V+F D + D+IN + + + ++D Sbjct: 8 NKVYGRYSAVFKDSFLRKIGDNFQT----VDFTD-SRTVDAINKSVDIFTEGKINPLLDE 62 Query: 168 LLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFR 227 LSPD T L+ ++AVYFK W F+ E T F + + V M++ Sbjct: 63 PLSPD------TSLLAISAVYFKAKWLMPFEKEFTSDYPFYVSPTEMVDVSMMSMYG--E 114 Query: 228 CGSTSAPNDLWYNF--IELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMV 285 + ++ + + NF IELPY G++ SM++ LP ++ L +I +++ W M Sbjct: 115 AFNHASVKESFGNFSIIELPYVGDT-SMVVILP-DNIDGLESIEQNLTDTNFKKWSDSMD 172 Query: 286 PKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKI 345 + V +PKF +L + L LG+T++F S +++ ++ + ++ V ++ K I Sbjct: 173 AMFIDVHIPKFKVTGSYNLVDALVKLGLTEVF-GSTGDYSNMS--NSDVSVDAMIHKTYI 229 Query: 346 EVSEDGTKASAATTAI 361 +V+E+ T+A+AAT+A+ Sbjct: 230 DVNEEYTEAAAATSAL 245 >1SNG-A nrPDB Length = 370 Score = 79.0 bits (193), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 91/378 (24%), Positives = 172/378 (45%), Gaps = 46/378 (12%) Query: 35 GIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKK 94 + + ++ ++ P ++ SP+ +A LG+L GA T+ +L ++ +L Sbjct: 18 ALHLHRRLAEAVPDGEVIWSPYSVACALGVLAAGARATTRTELTTLL---GTDPAPLLAA 74 Query: 95 INKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFE-DPASACDSI 153 +++A+ + TV ++V + F D +VR +F +P ++ Sbjct: 75 LDRAVTDSPDLASRTV---LWVSADVPVRSSFRATMHDRPDSDVRTADFRTNPEGVRATV 131 Query: 154 NAWVKNETRDMIDNLL-----SPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFV 208 NA + + TR MI LL +PDL R +L NA++ K W + F+ T+ TF Sbjct: 132 NADIADATRGMIRELLPQGAVTPDL------RAILTNALWAKARWTTPFEAHLTRAGTFR 185 Query: 209 AADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALP---TESSTPL 265 G +VP + + + + + L H E +++ + LP ++ P Sbjct: 186 TPRGPK-RVPFMHRTKTMPYATARG-----WRMVTLHAHDE-LAVDVLLPPGTNAAAVPT 238 Query: 266 SAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFA 325 + ++ + ++ + V++ LP+F L E L G+ +F +S A+ + Sbjct: 239 APLLTALHRRSAST--------SVELALPRFELTQPHQLVEVLAEAGVRTLFTAS-ADLS 289 Query: 326 KITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSS-PP----WFIVDRPFLFF 380 I+T L+V ++ +A++ V E G + +AAT A+++ + PP F VDRPF Sbjct: 290 GIST--VPLYVDTVIHQARLRVDERGAEGAAATAAMMLLAGAMPPRRTIRFSVDRPFHIV 347 Query: 381 IRHNPTGAVLFMGQINKP 398 +R GA+LF+G I P Sbjct: 348 VRRR--GAILFLGSIADP 363 >2OAY-A nrPDB Length = 390 Score = 69.3 bits (168), Expect = 3e-12, Method: Compositional matrix adjust. Identities = 88/358 (24%), Positives = 153/358 (42%), Gaps = 34/358 (9%) Query: 50 NIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVT 109 N+ SP IAS+L + LGA TK L ++ Y K +++A+ K + + Sbjct: 56 NMAFSPFSIASLLTQVLLGAGENTKTNLESILSYP-----KDFTCVHQALKGFTTKGVTS 110 Query: 110 VANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLL 169 V+ +F I FV ++ ++ R ++ A+ + IN WV T + I LL Sbjct: 111 VSQ-IFHSPDLAIRDTFVNASRTLYSSSPRVLSNNSDAN-LELINTWVAKNTNNKISRLL 168 Query: 170 SPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCG 229 D TRLVL+NA+Y WK+ F P+ T+ F + +VPM+ Sbjct: 169 DSLPSD---TRLVLLNAIYLSAKWKTTFDPKKTRMEPFHFKNS-VIKVPMM--------N 216 Query: 230 STSAPNDLWYNFIELPYHGE--------SISMLIALPTESSTPLSAIIPHISTKTIDSWM 281 S P +FI+ + ++S++I +P L + +S + M Sbjct: 217 SKKYP---VAHFIDQTLKAKVGQLQLSHNLSLVILVPQNLKHRLEDMEQALSPSVFKAIM 273 Query: 282 SIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFD-SSKANFAKITTGSENLHVSHIL 340 + + Q L + T ++ L ++ + FD S N +T + L VS + Sbjct: 274 EKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFDFSYDLNLCGLTEDPD-LQVSAMQ 332 Query: 341 QKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINKP 398 + +E++E G +A+AA+ + F V +PFLF + +FMG++ P Sbjct: 333 HQTVLELTETGVEAAAASAI--SVARTLLVFEVQQPFLFMLWDQQHKFPVFMGRVYDP 388 >1MTP-A nrPDB Length = 323 Score = 64.3 bits (155), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 70/324 (21%), Positives = 143/324 (44%), Gaps = 39/324 (12%) Query: 35 GIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKK 94 + + ++ ++ P ++ SP+ +A LG+L GA T+ +L ++ +L Sbjct: 14 ALHLHRRLAEAVPDGEVIWSPYSVACALGVLAAGARATTRTELTTLL---GTDPAPLLAA 70 Query: 95 INKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFE-DPASACDSI 153 +++A+ + TV ++V + F D +VR +F +P ++ Sbjct: 71 LDRAVTDSPDLASRTV---LWVSADVPVRSSFRATMHDRPDSDVRTADFRTNPEGVRATV 127 Query: 154 NAWVKNETRDMIDNLL-----SPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFV 208 NA + + TR MI LL +PDL R +L NA++ K W + F+ T++ TF Sbjct: 128 NADIADATRGMIRELLPQGAVTPDL------RAILTNALWAKARWTTPFEAHLTREGTFR 181 Query: 209 AADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALP---TESSTPL 265 G +VP + + + + + L H E +++ + LP ++ P Sbjct: 182 TPRGPK-RVPFMHRTKTMPYATARG-----WRMVTLHAHDE-LAVDVLLPPGTNAAAVPT 234 Query: 266 SAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFA 325 + ++ + ++ + V++ LP+F L E L G+ +F +S A+ + Sbjct: 235 APLLTALHRRSAST--------SVELALPRFELTQPHQLVEVLAEAGVRTLFTAS-ADLS 285 Query: 326 KITTGSENLHVSHILQKAKIEVSE 349 I+T L+V ++ +A++ V E Sbjct: 286 GISTVP--LYVDTVIHQARLRVDE 307 >5C98-A nrPDB Length = 382 Score = 58.2 bits (139), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 77/353 (21%), Positives = 145/353 (41%), Gaps = 21/353 (5%) Query: 50 NIVISPHGIASVLGMLQ--LGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDI 107 N +SP+ + L M GA + Q+A + V+ + +++ + + ++ Sbjct: 38 NCAVSPYHVRLALSMFYPLAGAAVQEDFQVAFGLPEDVHAAIEQQQRLAQQLHDGQH--- 94 Query: 108 VTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDN 167 + + V V+ ++ F FQ V V+ D + ++N++ + ++ D Sbjct: 95 LKALSFVLVEETLRLDSEFERLFHRTFQTTVEPVDLTDDIPSALAVNSFYQRANTEIEDF 154 Query: 168 LLSPDLID-GVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLS-V 225 + D+ +L+L + V RF P +T F + + +V + + V Sbjct: 155 IGEGDVFSLPPCHKLMLFSGVSVLTPLAIRFNPADTALELFQFINAPTQRVSTMHTTAFV 214 Query: 226 FRCGSTSAPNDLWYNFIELPYHGES-ISMLIALPTESSTPLSAIIPHISTKTIDSWMSIM 284 RC N+L +++P+ S +SML+ LP + T L I+ I+ + + Sbjct: 215 RRC----LHNELRCKVVDMPFDAASGLSMLVLLPYDG-TELRQIVNSITPAHLAQIDERL 269 Query: 285 VPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAK 344 + LPKF +TD K+ L LG +F+ + + S ++ +Q Sbjct: 270 QSCWTDLKLPKFFVREKTDPKQTLGKLGYGGVFEIDDLH---VFHDSGRTRLNGFIQHCY 326 Query: 345 IEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINK 397 + VSE G+ A S F +RPF+F IR G VL +G +K Sbjct: 327 LAVSESGSGIPAPPDT-----PSEFEFHANRPFMFLIRRTMDGNVLQVGNFSK 374 >5M3Y-A nrPDB Length = 458 Score = 50.4 bits (119), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 75/371 (20%), Positives = 155/371 (41%), Gaps = 38/371 (10%) Query: 48 HDNIVISPHGIASVLGMLQLGADGRTKKQLAMVM-----------RYGVNGVGKILKKIN 96 H V+SP + L L LGA T +L ++ R + V L+ + Sbjct: 96 HGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKQCTSRLDAHKVLSALQAVQ 155 Query: 97 KAIVSKKNKD-----IVTVANAVFVKNASEIEVPFVTRNKDVFQCEV--RNVNFEDPASA 149 +V++ D +++ VF ++ PFV + ++ V R+++F + A Sbjct: 156 GLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFV-QGLALYTPVVLPRSLDFTELDVA 214 Query: 150 CDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVA 209 + I+ +++ T + L +D + L V+F+G K + + + F Sbjct: 215 AEKIDRFMQAVTGWKTGSSLMGASVD---STLAFNTYVHFQG--KMKGFSLLAEPQEFWV 269 Query: 210 ADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAII 269 S VPML+ + F+ S ++ ++P+ ES S+L+ P +S L + Sbjct: 270 DQSTSVSVPMLSGMGTFQHWSDIQDQ---FSVTQVPF-TESASLLLIQPHYASD-LDKVE 324 Query: 270 PHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITT 329 + +WM + P+ + + +P+ DL++ L + + ++ N K++ Sbjct: 325 GLTFQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAIL-HTELNLQKLS- 382 Query: 330 GSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIV--DRPFLFFIRHNPTG 387 ++ + V +L E+ D + + +T + + P V +RPFLF + Sbjct: 383 -NDRIRVGEVLNSIFFELEADEREPTESTQQL----NKPEVLEVTLNRPFLFAVYDQSAT 437 Query: 388 AVLFMGQINKP 398 A+ F+G++ P Sbjct: 438 ALHFLGRVANP 448 >2WXZ-C nrPDB Length = 453 Score = 47.8 bits (112), Expect = 9e-06, Method: Compositional matrix adjust. Identities = 58/254 (22%), Positives = 109/254 (42%), Gaps = 14/254 (5%) Query: 145 DPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKK 204 DP A IN +V+ T ++ L +GV T L Y K R + T Sbjct: 210 DPVLAAQKINRFVQAVTGWKMNLPL-----EGVSTDSTLFFNTYVHFQGKMRGFSQLTGL 264 Query: 205 RTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTP 264 F + S VPML+ F+ S + N ++ +P GES+++L+ P + ++ Sbjct: 265 HEFWVDNSTSVSVPMLSGTGNFQHWSDAQNN---FSVTRVPL-GESVTLLLIQP-QCASD 319 Query: 265 LSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANF 324 L + + +W+ P+ +++ LP+ +L++ L ++ + ++AN Sbjct: 320 LDRVEVLVFQHDFLTWIKNPPPRAIRLTLPQLEIRGSYNLQDLLAQAKLSTLL-GAEANL 378 Query: 325 AKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHN 384 K+ G N V +L +E+ + G + +A + PFLF I Sbjct: 379 GKM--GDTNPRVGEVLNSILLEL-QAGEEEQPTESAQQPGSPEVLDVTLSSPFLFAIYER 435 Query: 385 PTGAVLFMGQINKP 398 +GA+ F+G+++ P Sbjct: 436 DSGALHFLGRVDNP 449 >2WXX-A nrPDB Length = 453 Score = 39.7 bits (91), Expect = 0.002, Method: Compositional matrix adjust. Identities = 58/256 (22%), Positives = 107/256 (41%), Gaps = 18/256 (7%) Query: 145 DPASACDSINAWVKNETRDMIDNLLSPDLIDGVLT--RLVLVNAVYFKGLWKSRFQPENT 202 DP A + IN ++K T ++ L +GV T L+ V+F+G + Q Sbjct: 210 DPVLATEKINRFIKAVTGWKMNLPL-----EGVSTDSTLLFNTYVHFQGTMRGFSQLPGV 264 Query: 203 KKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESS 262 + F + S VPM++ F+ S A N+ + L GE ++L+ P Sbjct: 265 HE--FWVDNSISVSVPMISGTGNFQHWS-DAQNNFSVTCVPL---GERATLLLIQP-HCI 317 Query: 263 TPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKA 322 + L + I + +W+ P+ +++ LP+ +L++ L + + ++A Sbjct: 318 SDLDRVEALIFQNDLLTWIENPPPRAIRLTLPQLEIRGSYNLQDLLAEDKLPTLL-GAEA 376 Query: 323 NFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIR 382 N I G N V +L +E+ + G + T+ + PFLF I Sbjct: 377 NLNNI--GDTNPRVGEVLNSILLEL-KAGEEEQPTTSVQQPGSPEALDVTLSSPFLFAIY 433 Query: 383 HNPTGAVLFMGQINKP 398 +G + F+G++N P Sbjct: 434 EQDSGTLHFLGRVNNP 449 >3L0D-A nrPDB Length = 356 Score = 30.8 bits (68), Expect = 1.1, Method: Compositional matrix adjust. Identities = 14/42 (33%), Positives = 25/42 (59%) Query: 70 DGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVA 111 + +T+ +M +R +NG G+I + I +AI+ +DI VA Sbjct: 13 EAQTQGPGSMSVRVAINGFGRIGRNILRAIIESGRQDIEVVA 54 >2KKH-A nrPDB Length = 95 Score = 29.6 bits (65), Expect = 2.1, Method: Compositional matrix adjust. Identities = 20/62 (32%), Positives = 32/62 (51%), Gaps = 4/62 (6%) Query: 19 CSHFNPLSLEELGSNTGIQVFNQIVKSRP----HDNIVISPHGIASVLGMLQLGADGRTK 74 C+ P+ L S G++ ++ IV SR HD+++ISP IA L +L A+ R Sbjct: 27 CTSEVPIIENILKSLDGVKEYSVIVPSRTVIVVHDSLLISPFQIAKALNEARLEANVRVN 86 Query: 75 KQ 76 + Sbjct: 87 GE 88 >3DOC-A nrPDB Length = 335 Score = 29.3 bits (64), Expect = 3.2, Method: Compositional matrix adjust. Identities = 14/33 (42%), Positives = 19/33 (57%) Query: 79 MVMRYGVNGVGKILKKINKAIVSKKNKDIVTVA 111 M +R +NG G+I + I +AIV DI VA Sbjct: 1 MAVRVAINGFGRIGRNILRAIVESGRTDIQVVA 33 >4WVM-B nrPDB Length = 700 Score = 28.5 bits (62), Expect = 4.9, Method: Compositional matrix adjust. Identities = 30/132 (22%), Positives = 60/132 (45%), Gaps = 20/132 (15%) Query: 126 FVTRNKDVFQCEVRNV---NFEDPASACDSINAWVKNETRDMIDNLLSP--DLIDGVLTR 180 F R+ D + + N+ N + P + +S+N W++ E R++ N+L D++ + Sbjct: 327 FAIRSGDEDESALLNLFEENLQSPFN-IESLNMWMEFEEREI--NVLRSCMDILTKAKPK 383 Query: 181 LVLVNAVYFKGLWKSRFQ-------PENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSA 233 ++ V FKGL+ S+ + TK F+ + P ++ R + Sbjct: 384 VIFNQGVLFKGLYDSKVKHALCYVFTNVTKNDVFLNVLNEFLDSPQ-SRPKKLR----PS 438 Query: 234 PNDLWYNFIELP 245 P D WY++ ++P Sbjct: 439 PKDYWYSYDDIP 450 >2W5S-A nrPDB Length = 424 Score = 28.5 bits (62), Expect = 6.1, Method: Compositional matrix adjust. Identities = 18/59 (30%), Positives = 28/59 (47%) Query: 65 LQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIE 123 L G D +K +V + + K K +N I S KN +++T A F KN ++E Sbjct: 328 LMFGTDLFSKGHNQVVPFRNGDFITKDYKYVNGKIYSNKNNELITTQPADFEKNKKQVE 386 >4N9N-A nrPDB Length = 438 Score = 28.1 bits (61), Expect = 6.8, Method: Compositional matrix adjust. Identities = 18/53 (33%), Positives = 28/53 (52%), Gaps = 6/53 (11%) Query: 320 SKANFAKITTGSENLHVSH------ILQKAKIEVSEDGTKASAATTAILIARS 366 S + ++ TG E SH +L++A +E+SE+ T A A+ ILI S Sbjct: 64 SATHLSRTETGLEQYVSSHRLDALRLLREAVLEISENNTDALVASALILIMDS 116 >1KV9-A nrPDB Length = 668 Score = 28.1 bits (61), Expect = 7.8, Method: Compositional matrix adjust. Identities = 18/69 (26%), Positives = 33/69 (47%), Gaps = 3/69 (4%) Query: 64 MLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIE 123 + +L DG+ +K ++M+ NG +L + N ++S + VT A V + +E Sbjct: 304 LAELNIDGKPRK---VLMQAPKNGFFYVLDRTNGKLISAEKFGKVTWAEKVDLATGRPVE 360 Query: 124 VPFVTRNKD 132 P V K+ Sbjct: 361 APGVRYEKE 369 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 6EE5-A nrPDB 496 e-141 4DY0-A nrPDB 480 e-136 1C5G-A nrPDB 433 e-122 4KDS-A nrPDB 407 e-114 1BY7-A nrPDB 407 e-114 3LW2-A nrPDB 406 e-114 2VDY-A nrPDB 398 e-111 4DTE-A nrPDB 398 e-111 4GA7-A nrPDB 395 e-110 3NE4-A nrPDB 394 e-110 4EB1-I nrPDB 393 e-110 1ATT-A nrPDB 390 e-109 6HGE-B nrPDB 387 e-108 2OL2-A nrPDB 387 e-108 5HGC-A nrPDB 383 e-107 1YXA-A nrPDB 376 e-105 4P0F-A nrPDB 372 e-103 4ZK0-A nrPDB 368 e-102 1HLE-A nrPDB 368 e-102 1UHG-A nrPDB 364 e-101 4Y40-A nrPDB 363 e-100 5NCS-A nrPDB 363 e-100 2H4Q-A nrPDB 360 e-100 3DY0-A nrPDB 356 6e-99 3NDA-A nrPDB 356 9e-99 4AJT-A nrPDB 356 1e-98 3F02-A nrPDB 355 2e-98 2H4P-A nrPDB 352 1e-97 1JMJ-A nrPDB 351 4e-97 6F02-A nrPDB 346 8e-96 2XN5-A nrPDB 340 5e-94 2V95-A nrPDB 338 2e-93 1XQJ-A nrPDB 334 4e-92 1QMB-A nrPDB 334 4e-92 1K9O-I nrPDB 333 8e-92 1SEK-A nrPDB 326 9e-90 3ZHA-A nrPDB 326 1e-89 5NCU-A nrPDB 324 4e-89 6CJ7-A nrPDB 320 6e-88 2R9Y-A nrPDB 318 3e-87 5INW-A nrPDB 317 5e-87 4AJU-A nrPDB 317 7e-87 6F4U-A nrPDB 316 1e-86 3PZF-A nrPDB 304 6e-83 1IMV-A nrPDB 303 9e-83 3STO-A nrPDB 301 3e-82 3LE2-A nrPDB 299 9e-82 3OZQ-A nrPDB 295 2e-80 1JJO-C nrPDB 284 5e-77 2PEF-A nrPDB 283 1e-76 1C8O-A nrPDB 272 2e-73 2OAY-A nrPDB 262 2e-70 1SNG-A nrPDB 256 2e-68 6BJ5-B nrPDB 249 1e-66 5C98-A nrPDB 242 1e-64 5M3Y-A nrPDB 239 2e-63 1MTP-A nrPDB 230 8e-61 2WXZ-C nrPDB 227 5e-60 1M93-B nrPDB 224 7e-59 Sequences not found previously or not previously below threshold: 2WXX-A nrPDB 214 6e-56 4R9I-A nrPDB 85 6e-17 4P2L-A nrPDB 34 0.11 3T59-A nrPDB 33 0.19 3LLI-A nrPDB 33 0.31 3N2S-A nrPDB 31 0.71 1XZW-A nrPDB 31 0.79 5TUM-A nrPDB 31 0.95 3ES8-A nrPDB 30 1.8 3JD5-e nrPDB 30 2.0 6CW2-D nrPDB 30 2.4 4WY5-A nrPDB 30 2.5 2QGH-A nrPDB 30 2.7 5W76-A nrPDB 29 3.9 1F2V-A nrPDB 28 5.1 5BRA-A nrPDB 28 5.5 3W6J-B nrPDB 28 5.8 4ZR0-A nrPDB 28 7.2 3BNF-A nrPDB 28 7.4 4ZR1-A nrPDB 28 8.6 1KEA-A nrPDB 28 8.9 >6EE5-A nrPDB Length = 379 Score = 496 bits (1277), Expect = e-141, Method: Composition-based stats. Identities = 139/373 (37%), Positives = 204/373 (54%), Gaps = 15/373 (4%) Query: 27 LEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVN 86 L E ++ ++ ++ KS P NI SP I+S L ML LGA G T Q+ + + Sbjct: 21 LAEANTDFAFSLYRELAKSSPDKNIFFSPVSISSALAMLSLGAKGDTHTQILEGLGFNSE 80 Query: 87 -GVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFED 145 + + + + + + K + AN +FV + ++ F+ +K ++Q E +V+F D Sbjct: 81 ADIHQGFQHLLQTLNRPKG-LQLKTANGLFVDKSLKLLDSFLEDSKKLYQAEAFSVDF-D 138 Query: 146 PASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKR 205 P A IN WV+ +T I +LL D T LVLVNA+YFKG WK F PENTK+ Sbjct: 139 PEEAKKQINDWVEKQTNGKIKDLLKDLDSD---TVLVLVNAIYFKGKWKKPFDPENTKEE 195 Query: 206 TFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPL 265 F + + +VPM++Q F ++L +ELPY G + SMLI LP E L Sbjct: 196 DFHVDEKTTVKVPMMSQKGKFYYYH---DDELSCKVLELPYKGNA-SMLIILPDEG--GL 249 Query: 266 SAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFA 325 + ++ +T+ W+ + + V++ LPKF DLKE L LGITD+F A+ + Sbjct: 250 QHLEQSLTPETLSKWLKSLTRRSVELYLPKFKIEGTYDLKEVLSNLGITDLFSPG-ADLS 308 Query: 326 KITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNP 385 IT E L+VS + KA +EV+E+GT+A+AAT I S PP F DRPFLF IR N Sbjct: 309 GITE--EKLYVSKAVHKAVLEVNEEGTEAAAATFLEAIPMSIPPEFKADRPFLFLIRENK 366 Query: 386 TGAVLFMGQINKP 398 TG++LFMG++ P Sbjct: 367 TGSILFMGKVVNP 379 >4DY0-A nrPDB Length = 379 Score = 480 bits (1236), Expect = e-136, Method: Composition-based stats. Identities = 379/379 (100%), Positives = 379/379 (100%) Query: 20 SHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAM 79 SHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAM Sbjct: 1 SHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAM 60 Query: 80 VMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVR 139 VMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVR Sbjct: 61 VMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVR 120 Query: 140 NVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQP 199 NVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQP Sbjct: 121 NVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQP 180 Query: 200 ENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPT 259 ENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPT Sbjct: 181 ENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPT 240 Query: 260 ESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDS 319 ESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDS Sbjct: 241 ESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDS 300 Query: 320 SKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLF 379 SKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLF Sbjct: 301 SKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLF 360 Query: 380 FIRHNPTGAVLFMGQINKP 398 FIRHNPTGAVLFMGQINKP Sbjct: 361 FIRHNPTGAVLFMGQINKP 379 >1C5G-A nrPDB Length = 402 Score = 433 bits (1115), Expect = e-122, Method: Composition-based stats. Identities = 157/380 (41%), Positives = 234/380 (61%), Gaps = 4/380 (1%) Query: 21 HFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMV 80 H P + L S+ G++VF Q+ ++ N+V SP+G+ASVL MLQL G T++Q+ Sbjct: 25 HHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAA 84 Query: 81 MRYGVN--GVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEV 138 M + ++ G+ L+ + K ++ NKD ++ +A+FV+ ++ F+ +F+ V Sbjct: 85 MGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTV 144 Query: 139 RNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQ 198 + V+F + A IN WVK T+ MI NLL +D LTRLVLVNA+YF G WK+ F Sbjct: 145 KQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVD-QLTRLVLVNALYFNGQWKTPFP 203 Query: 199 PENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALP 258 +T +R F +DG + VPM+AQ + F + P+ +Y+ +ELPYHG+++SM IA P Sbjct: 204 DSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAP 263 Query: 259 TESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFD 318 E PLSA+ +S + I W M ++LPKF+ + DL++PL+ LG+TDMF Sbjct: 264 YEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFR 323 Query: 319 SSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFL 378 +A+F ++ E LHV+ LQK KIEV+E GT AS++T I+ AR +P I+DRPFL Sbjct: 324 QFQADFTSLS-DQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFL 382 Query: 379 FFIRHNPTGAVLFMGQINKP 398 F +RHNPTG VLFMGQ+ +P Sbjct: 383 FVVRHNPTGTVLFMGQVMEP 402 >4KDS-A nrPDB Length = 386 Score = 407 bits (1047), Expect = e-114, Method: Composition-based stats. Identities = 148/376 (39%), Positives = 229/376 (60%), Gaps = 7/376 (1%) Query: 25 LSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYG 84 +L+E ++ G++VF+Q+ ++ N+ SP+G+A++L M QLGA G T K L + + Sbjct: 13 SNLQEKQTDFGMRVFSQVAQNSKGSNLAFSPYGVATILAMAQLGAGGNTLKTLNAKLGFS 72 Query: 85 VN--GVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVN 142 + G+ + + + + I S++ V +A+ V V+ +E F FQ ++ Sbjct: 73 LQERGMARQQRLLQRDISSEEG---VELASGVMVERKMALEKGFRRGLGKAFQASPHQLD 129 Query: 143 FEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENT 202 F P A D INAWV + T I + LS + TR+VL+NA++F+GLWK F P+ T Sbjct: 130 FSRPDQALDIINAWVSDHTAGTIPSFLSSGALTDE-TRMVLLNALHFQGLWKVPFDPKMT 188 Query: 203 KKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESS 262 ++R F A+G S VPM+ F+ G P+ + Y+ IE+PY GES+SML+ P E Sbjct: 189 EERLFHCANGSSVPVPMMRLTHRFKYGEFVTPDGVDYDVIEVPYEGESLSMLLVSPFEPE 248 Query: 263 TPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKA 322 TP+S++ ++T+ + W M + Q++LP+FT ++ +LK L +G+ DMF+ +KA Sbjct: 249 TPVSSLSSELTTQRLQQWRQEMRSVKRQLVLPRFTLDSEVELKSILIQMGLGDMFNLAKA 308 Query: 323 NFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIR 382 +F +ITT + L VS +LQK KIEV+E+GTKASAAT AIL +R + ++RPFLF I Sbjct: 309 DFTRITT-EQPLCVSKVLQKVKIEVNEEGTKASAATAAILFSRMAVEEITMNRPFLFLIH 367 Query: 383 HNPTGAVLFMGQINKP 398 H TGAVLFMGQ+N+P Sbjct: 368 HKSTGAVLFMGQVNQP 383 >1BY7-A nrPDB Length = 382 Score = 407 bits (1046), Expect = e-114, Method: Composition-based stats. Identities = 110/382 (28%), Positives = 193/382 (50%), Gaps = 19/382 (4%) Query: 30 LGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYG----- 84 + + +F + K+ P N+ +SP I+S + M+ +G+ G T+ Q+A V+++ Sbjct: 7 ANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQFNEVGAA 66 Query: 85 VNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNF- 143 + + + ++ AI + ++ N +F + ++ ++ + + E + V+F Sbjct: 67 ADKIHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFL 126 Query: 144 EDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTK 203 E A IN+WVK +T+ I NLL +DG TR+VLVNAVYFKG WK+ F+ + Sbjct: 127 ECAEEARKKINSWVKTQTKGKIPNLLPEGSVDGD-TRMVLVNAVYFKGKWKTPFEKKLNG 185 Query: 204 KRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTE--- 260 F + V M+ G DL +ELPY G+ +SM + LP E Sbjct: 186 LYPFRVNSAQRTPVQMMYLREKLNIGYIE---DLKAQILELPYAGD-VSMFLLLPDEIAD 241 Query: 261 SSTPLSAIIPHISTKTIDSWM--SIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFD 318 ST L + I+ ++ W M V+V +P+F +L+ L+ +G+ D F+ Sbjct: 242 VSTGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFN 301 Query: 319 SSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSP--PWFIVDRP 376 +ANF+ ++ +L +S + +A ++V+E+GT+A+A T ++ R+ P F+ D P Sbjct: 302 KGRANFSGMSE-RNDLFLSEVFHQAMVDVNEEGTEAAAGTGGVMTGRTGHGGPQFVADHP 360 Query: 377 FLFFIRHNPTGAVLFMGQINKP 398 FLF I H T +LF G+ + P Sbjct: 361 FLFLIMHKITNCILFFGRFSSP 382 >3LW2-A nrPDB Length = 379 Score = 406 bits (1044), Expect = e-114, Method: Composition-based stats. Identities = 145/373 (38%), Positives = 229/373 (61%), Gaps = 4/373 (1%) Query: 28 EELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVN- 86 ++ G++VF Q+V++ N+V SP+G++SVL MLQ+ G+T++Q+ M + VN Sbjct: 9 AHQATDFGVKVFQQVVQASKDRNVVFSPYGVSSVLAMLQMTTAGKTRRQIQDAMGFKVNE 68 Query: 87 -GVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFED 145 G L++++K ++ NK+ ++ A+A+FV+ E+ F+ +FQ V+ V+F + Sbjct: 69 KGTAHALRQLSKELMGPWNKNEISTADAIFVQRDLELVQGFMPHFFKLFQTMVKQVDFSE 128 Query: 146 PASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKR 205 A IN WV+ T+ MI++LL+ +D LTRLVLVNA+YF G WK+ F +T +R Sbjct: 129 VERARFIINDWVERHTKGMINDLLAKGAVDE-LTRLVLVNALYFSGQWKTPFLEASTHQR 187 Query: 206 TFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPL 265 F +DG + VPM+AQ + F + P+ L Y+ +ELPY G+++SM IA P E L Sbjct: 188 LFHKSDGSTVSVPMMAQSNKFNYTEFTTPDGLEYDVVELPYQGDTLSMFIAAPFEKDVHL 247 Query: 266 SAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFA 325 SA+ + + I W M +ILPKF+ + DL+ PL+ LG+ DMF ++ A+F Sbjct: 248 SALTNILDAELIRQWKGNMTRLPRLLILPKFSLETEVDLRGPLEKLGMPDMFSATLADFT 307 Query: 326 KITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNP 385 ++ E L V+ LQK +IEV+E GT AS++T ++ AR +P ++DR FLF +RHNP Sbjct: 308 SLS-DQEQLSVAQALQKVRIEVNESGTVASSSTAFVISARMAPTEMVIDRSFLFVVRHNP 366 Query: 386 TGAVLFMGQINKP 398 T +LFMGQ+ +P Sbjct: 367 TETILFMGQVMEP 379 >2VDY-A nrPDB Length = 373 Score = 398 bits (1024), Expect = e-111, Method: Composition-based stats. Identities = 104/378 (27%), Positives = 190/378 (50%), Gaps = 16/378 (4%) Query: 26 SLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGV 85 L + ++ +V P NI ISP I+ L ML LG G T+ QL + + + Sbjct: 6 GLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRAQLLQGLGFNL 65 Query: 86 NG-----VGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRN 140 + + + +++ +T+ NA+F+ + E+ F K ++ EV Sbjct: 66 TERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSLELLESFSADIKHYYESEVLA 125 Query: 141 VNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPE 200 +NF+D A+A IN++VKN+T+ I +L S + LVLVN ++FKG W F Sbjct: 126 MNFQDWATASRQINSYVKNKTQGKIVDLFSGLDSPAI---LVLVNYIFFKGTWTQPFDLA 182 Query: 201 NTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTE 260 +T++ F + +VPM+ Q S ++L +++ Y G ++ LP + Sbjct: 183 STREENFYVDETTVVKVPMMLQSSTISY---LHDSELPCQLVQMNYVGNG-TVFFILPDK 238 Query: 261 SSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSS 320 ++ +I +S TI+ W + + +V + +PK T DL + L+ +GI D+F ++ Sbjct: 239 GK--MNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLF-TT 295 Query: 321 KANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFF 380 +ANF++IT ++ L S ++ KA ++++E+GT+A+ A I RS P ++PF+ Sbjct: 296 QANFSRITQDAQ-LKSSKVVHKAVLQLNEEGTEAAGAMFLEAIPRSKPIILRFNQPFIIM 354 Query: 381 IRHNPTGAVLFMGQINKP 398 I + T + LF+ ++ P Sbjct: 355 IFDHFTWSSLFLARVMNP 372 >4DTE-A nrPDB Length = 374 Score = 398 bits (1023), Expect = e-111, Method: Composition-based stats. Identities = 145/374 (38%), Positives = 220/374 (58%), Gaps = 7/374 (1%) Query: 27 LEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVN 86 +++ ++ G+QVF + V+S P N+ +SP+GIASVLGM Q+GA G T K LA M Y + Sbjct: 3 IQDKQTDFGLQVFAEAVQSAPDRNLALSPYGIASVLGMAQMGAYGATLKLLASKMGYSLQ 62 Query: 87 --GVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFE 144 G+ K+ + + + + S+ D V VA+ V V +E F FQ ++F Sbjct: 63 ERGMPKLQRLLQRDLASE---DGVEVASGVMVDRKIILEKVFRRSLSKAFQSVPHQIDFS 119 Query: 145 DPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKK 204 P A IN+W + T MI L ++ LTRLV +NA++F G+WK+ F P NT++ Sbjct: 120 QPEMARQVINSWTSDHTDGMISEFLPSGVLSE-LTRLVFLNALHFHGVWKTPFDPRNTRE 178 Query: 205 RTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTP 264 + F +G + VPM+ F G + + + Y+ IE+PY GESISML+ P E P Sbjct: 179 QLFHTVNGSAVSVPMMTTTQKFNYGEFVSKDGVDYDVIEMPYEGESISMLLVTPFEKDVP 238 Query: 265 LSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANF 324 LSA+ +S+ I W M Q+ +P+F+ + DLK L +G+ D+F S+A+F Sbjct: 239 LSALNKELSSSRIHQWRQEMRKISKQLSIPRFSMDTEIDLKSTLSRMGLGDIFSQSRADF 298 Query: 325 AKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHN 384 ++ITT E L VS +LQ+ K+EV+E+GTK S+AT A++ +R + +DRPF F I+H Sbjct: 299 SRITT-EEPLCVSKVLQRVKLEVNEEGTKGSSATAAVIYSRMAVEEITLDRPFFFLIQHK 357 Query: 385 PTGAVLFMGQINKP 398 PTGA+LF GQ+ +P Sbjct: 358 PTGALLFSGQLTQP 371 >4GA7-A nrPDB Length = 389 Score = 395 bits (1015), Expect = e-110, Method: Composition-based stats. Identities = 124/381 (32%), Positives = 195/381 (51%), Gaps = 14/381 (3%) Query: 27 LEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYG-V 85 L + + +F + ++ P NI ISP I+S + M+ LG G T QL+ + V Sbjct: 14 LSSANTRFALDLFLALSENNPAGNIFISPFSISSAMAMVFLGTRGNTAAQLSKTFHFNTV 73 Query: 86 NGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFED 145 V + +N I + I+ +AN ++ + F+ + + ++ +V+F+ Sbjct: 74 EEVHSRFQSLNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQH 133 Query: 146 -PASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKK 204 A +IN WVK +T I LL+ ++D +T+LVLVNA+YFKG WK +F E T Sbjct: 134 ASEDARKTINQWVKGQTEGKIPELLASGMVDN-MTKLVLVNAIYFKGNWKDKFMKEATTN 192 Query: 205 RTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPT---ES 261 F V M+ Q F G DL +ELPY GE +SM+I LP + Sbjct: 193 APFRLNKKDRKTVKMMYQKKKFAYGYIE---DLKCRVLELPYQGEELSMVILLPDDIEDE 249 Query: 262 STPLSAIIPHISTKTIDSWMS--IMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDS 319 ST L I ++ + + W + V V LP+F L L LG+ D+F+S Sbjct: 250 STGLKKIEEQLTLEKLHEWTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNS 309 Query: 320 SKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPW--FIVDRPF 377 SKA+ + ++ G+ ++ +S I+ K+ +EV+E+GT+A+AAT I P F D PF Sbjct: 310 SKADLSGMS-GARDIFISKIVHKSFVEVNEEGTEAAAATAGIATFCMDDPEENFTADHPF 368 Query: 378 LFFIRHNPTGAVLFMGQINKP 398 LFFIRHN +G++LF+G+ + P Sbjct: 369 LFFIRHNSSGSILFLGRFSSP 389 >3NE4-A nrPDB Length = 424 Score = 394 bits (1012), Expect = e-110, Method: Composition-based stats. Identities = 91/372 (24%), Positives = 169/372 (45%), Gaps = 16/372 (4%) Query: 32 SNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGV--- 88 + ++ Q+ NI SP IA+ ML LG T ++ + + + + Sbjct: 61 AEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEA 120 Query: 89 --GKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDP 146 + +++ + + ++ +T N +F+ ++ F+ K ++ E VNF D Sbjct: 121 QIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDT 180 Query: 147 ASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRT 206 A IN +V+ T+ I +L+ D T LVN ++FKG W+ F+ ++T++ Sbjct: 181 EEAKKQINDYVEKGTQGKIVDLVKELDRD---TVFALVNYIFFKGKWERPFEVKDTEEED 237 Query: 207 FVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLS 266 F + +VPM+ +L +F + L + + Y G + ++ LP E L Sbjct: 238 FHVDQVTTVKVPMMKRLGMF---NIQHCKKLSSWVLLMKYLGNATAIFF-LPDEGK--LQ 291 Query: 267 AIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAK 326 + ++ I ++ + + LPK + DLK L LGIT +F S+ A+ + Sbjct: 292 HLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVF-SNGADLSG 350 Query: 327 ITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPT 386 +T + L +S + KA + + E GT+A+ A I S PP ++PF+F + T Sbjct: 351 VTEEA-PLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPMSIPPEVKFNKPFVFLMIEQNT 409 Query: 387 GAVLFMGQINKP 398 + LFMG++ P Sbjct: 410 KSPLFMGKVVNP 421 >4EB1-I nrPDB Length = 440 Score = 393 bits (1009), Expect = e-110, Method: Composition-based stats. Identities = 115/392 (29%), Positives = 198/392 (50%), Gaps = 25/392 (6%) Query: 27 LEELGSNTGIQVFNQIVKSRPH-DNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGV 85 L + S + + S+ DNI +SP I++ M +LGA T +QL V ++ Sbjct: 51 LSKANSRFATTFYQHLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLMEVFKFDT 110 Query: 86 ------NGVGKILKKINKAIVSKKNKDI-VTVANAVFVKNASEIEVPFVTRNKDVFQCEV 138 + + K+N + K NK + AN +F + + ++ V+ ++ Sbjct: 111 ISEKTSDQIHFFFAKLNCRLYRKANKASKLVSANRLFGDKSLTFNETYQDISELVYGAKL 170 Query: 139 RNVNFE-DPASACDSINAWVKNETRDMIDNLLSPDLID-------GVLTRLVLVNAVYFK 190 + ++F+ + + +IN WV N+T I +++ + I+ T LVLVN +YFK Sbjct: 171 QPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINVLVLVNTRTSTVLVLVNTIYFK 230 Query: 191 GLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGES 250 GLWKS+F PENT+K F ADG+S M+ Q FR + +ELP+ G+ Sbjct: 231 GLWKSKFSPENTRKELFYKADGESCSASMMYQEGKFRYRRVA----EGTQVLELPFKGDD 286 Query: 251 ISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKV 310 I+M++ LP + L+ + ++ + + W+ + + V +P+F LKE L+ Sbjct: 287 ITMVLILPKPEKS-LAKVEKELTPEVLQEWLDELEEMMLVVHMPRFRIEDGFSLKEQLQD 345 Query: 311 LGITDMFDSSKANFAKI-TTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPP 369 +G+ D+F K+ I G ++L+VS KA +EV+E+G++A+A+T ++ RS P Sbjct: 346 MGLVDLFSPEKSKLPGIVAEGRDDLYVSDAFHKAFLEVNEEGSEAAASTAVVIAGRSLNP 405 Query: 370 ---WFIVDRPFLFFIRHNPTGAVLFMGQINKP 398 F +RPFL FIR P ++FMG++ P Sbjct: 406 NRVTFKANRPFLVFIREVPLNTIIFMGRVANP 437 >1ATT-A nrPDB Length = 429 Score = 390 bits (1003), Expect = e-109, Method: Composition-based stats. Identities = 114/385 (29%), Positives = 194/385 (50%), Gaps = 19/385 (4%) Query: 27 LEELGSNTGIQVFNQIVKS-RPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGV 85 L + S+ + + S +DNI +SP I++ M +LGA T QL V ++ Sbjct: 48 LSKANSHFATAFYQHLADSKNNNDNIFLSPLSISTAFAMTKLGACNNTLTQLMEVFKFDT 107 Query: 86 ------NGVGKILKKINKAIVSKKNKDI-VTVANAVFVKNASEIEVPFVTRNKDVFQCEV 138 + + K+N + K NK + AN +F + + ++ V+ ++ Sbjct: 108 ISEKTSDQIHFFFAKLNCRLYRKANKSSELVSANRLFGDKSITFNETYQDISEVVYGAKL 167 Query: 139 RNVNFE-DPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRF 197 + ++F+ + + +IN W+ N+T I +++ P I+ T LVLVN +YFKGLWKS+F Sbjct: 168 QPLDFKGNAEQSRLTINQWISNKTEGRITDVIPPQAINE-FTVLVLVNTIYFKGLWKSKF 226 Query: 198 QPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIAL 257 PENT+K F ADG+S V M+ Q S FR + +ELP+ G+ I+M++ L Sbjct: 227 SPENTRKELFYKADGESCSVLMMYQESKFRYRRVAEST----QVLELPFKGDDITMVLIL 282 Query: 258 PTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMF 317 P T L+ + ++ + W+ + + V +P+F +KE L+ +G+ D+F Sbjct: 283 PKLEKT-LAKVEQELTPDMLQEWLDELTETLLVVHMPRFRIEDSFSVKEQLQDMGLEDLF 341 Query: 318 DSSKANFAKI-TTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIAR---SSPPWFIV 373 K+ I G +L+VS KA +EV+E+G++A+A+T + R S F Sbjct: 342 SPEKSRLPGIVAEGRSDLYVSDAFHKAFLEVNEEGSEAAASTVISIAGRSLNSDRVTFKA 401 Query: 374 DRPFLFFIRHNPTGAVLFMGQINKP 398 +RPFL IR ++FMG++ P Sbjct: 402 NRPFLVLIREVALNTIIFMGRVANP 426 >6HGE-B nrPDB Length = 409 Score = 387 bits (995), Expect = e-108, Method: Composition-based stats. Identities = 103/384 (26%), Positives = 185/384 (48%), Gaps = 22/384 (5%) Query: 26 SLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGV 85 L + ++ Q+V P N++ SP I++ L L LGA T ++ +++ + Sbjct: 34 GLASANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNL 93 Query: 86 NG-----VGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRN 140 + + + + + + ++ +++ NA+FVK + F K ++ E Sbjct: 94 TETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFA 153 Query: 141 VNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPE 200 +F+D A+A IN +VKN TR I +L+ T +VLVN ++FK W+ F P+ Sbjct: 154 TDFQDSAAAKKLINDYVKNGTRGKITDLIKDL---DSQTMMVLVNYIFFKAKWEMPFDPQ 210 Query: 201 NTKKRTFVAADGKSYQVPMLAQLS-VFRCGSTSAPNDLWYNFIELPYHGESISMLIALPT 259 +T + F + K VPM++ +L ++L Y G + S L LP Sbjct: 211 DTHQSRFYLSKKKWVMVPMMSLHHLTIPYFR---DEELSCTVVQLNYTGNA-SALFILPD 266 Query: 260 ESSTPLSAIIPHISTKTIDSWMSIMVPKRV-QVILPKFTAVAQTDLKEPLKVLGITDMFD 318 + + + +S +T++ W + + + ++ LPKF+ +L + L LGI + F Sbjct: 267 Q--DKMEEVEAMLSRETLNRWGDSLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAFT 324 Query: 319 SSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPW----FIVD 374 S KA+ + IT G+ NL VS ++ KA ++V E+GT+ASAAT + S+ + Sbjct: 325 S-KADLSGIT-GARNLAVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTIVRFN 382 Query: 375 RPFLFFIRHNPTGAVLFMGQINKP 398 RPFL I + T ++ FM ++ P Sbjct: 383 RPFLMIIVDHFTWSIFFMSKVTNP 406 >2OL2-A nrPDB Length = 395 Score = 387 bits (995), Expect = e-108, Method: Composition-based stats. Identities = 100/374 (26%), Positives = 191/374 (51%), Gaps = 22/374 (5%) Query: 33 NTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVN-----G 87 + ++ + + P NI SP I+ L ML LGA TK Q+ + + Sbjct: 36 DFTFDLYRALASAAPSQNIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKE 95 Query: 88 VGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPA 147 + + +++ + + ++ +++ NA+F +++ FV+ K ++ + NF D A Sbjct: 96 LHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSA 155 Query: 148 SACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTF 207 A IN +V +T+ I +LL + V+ ++VN ++FK W++ F + T+++ F Sbjct: 156 GAMKQINDYVAKQTKGKIVDLLKNLDSNAVV---IMVNYIFFKAKWETSFNHKGTQEQDF 212 Query: 208 VAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSA 267 +VPM+++ + +L + +PY G + ++ I LP+E + Sbjct: 213 YVTSETVVRVPMMSREDQYHY---LLDRNLSCRVVGVPYQGNATALFI-LPSEGK--MQQ 266 Query: 268 IIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKI 327 + +S KT+ W+ + +++++ LPKF+ L++ L LGI+++F S A+ + I Sbjct: 267 VENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTS-HADLSGI 325 Query: 328 TTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPP---WFIVDRPFLFFIRHN 384 + S N+ VS ++ KA +EV E GT+A+AAT I RS+ + +RPFL FI N Sbjct: 326 SNHS-NIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDN 384 Query: 385 PTGAVLFMGQINKP 398 +LF+G++N+P Sbjct: 385 ---NILFLGKVNRP 395 >5HGC-A nrPDB Length = 380 Score = 383 bits (983), Expect = e-107, Method: Composition-based stats. Identities = 100/373 (26%), Positives = 181/373 (48%), Gaps = 16/373 (4%) Query: 31 GSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGV-- 88 ++ Q F ++ + P+ NI SP I++ ML LGA T+ Q+ + + + + Sbjct: 15 NADFAFQFFREVTQEAPNKNIFYSPVSISTAFAMLALGARSATQSQILEGLAFNLTEIQE 74 Query: 89 ---GKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFED 145 + + + + + + NA+FV A + F+ K ++Q E +F Sbjct: 75 KEIHEGFHNLIHMLNHPEGGVQLNMMNAIFVTAALALLRKFLDDAKALYQLEAFTTDFNK 134 Query: 146 PASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKR 205 P A IN +++ +T I NL+ T ++L + VYFKG W+ F+ E+T++R Sbjct: 135 PTEAEKQINDYIERKTHGKITNLVKDM---DPQTVMLLASFVYFKGSWEKPFEAEHTEER 191 Query: 206 TFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPL 265 F + +VPM+ Q+ F +L + L Y+G + + L+ LP + + Sbjct: 192 EFFVDAETTVKVPMMYQMGRF---DFYFDEELSCTVVRLHYNGSATAFLV-LPAKGK--M 245 Query: 266 SAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFA 325 + + +TI W + + + + PKF+ ++ L+ +GI D+F +++A+ + Sbjct: 246 KQLEQTLDKETIQKWSDHLFQRFMNLYFPKFSISGSYEISNTLRKMGIVDVF-TNQADLS 304 Query: 326 KITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNP 385 IT GS +L VS ++ KA ++V E GT+A+AAT ++ S PP PFL I Sbjct: 305 GIT-GSPDLKVSKVVHKASLDVDEKGTEAAAATAVEIMPISFPPTIEFSHPFLMLIFDRD 363 Query: 386 TGAVLFMGQINKP 398 T + LF+G+I P Sbjct: 364 TNSTLFIGKIVNP 376 >1YXA-A nrPDB Length = 398 Score = 376 bits (967), Expect = e-105, Method: Composition-based stats. Identities = 104/388 (26%), Positives = 195/388 (50%), Gaps = 19/388 (4%) Query: 20 SHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAM 79 + + L+L + ++ ++ ++V P NIV SP I++ L ++ LGA G T +++ Sbjct: 20 TQLDSLTLASINTDFAFSLYKELVLKNPDTNIVFSPLSISAALALVSLGAKGNTLEEILE 79 Query: 80 VMRYGVN-----GVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVF 134 +++ + + + + + + K++ ++ +A+F++ +I F + K ++ Sbjct: 80 GLKFNLTETSEADIHQGFGHLLQRLNQPKDQVQISTGSALFIEKRQQILTEFQEKAKTLY 139 Query: 135 QCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWK 194 Q E +F+ P A IN +V+ +T+ MI L+S T +VLVN +YFK WK Sbjct: 140 QAEAFTADFQQPRQAKKLINDYVRKQTQGMIKELVSDL---DKRTLMVLVNYIYFKAKWK 196 Query: 195 SRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISML 254 F P +T K F + VPM++ + +L +EL Y G + S L Sbjct: 197 VPFDPLDTFKSEFYCGKRRPVIVPMMSMEDL--TTPYFRDEELSCTVVELKYTGNA-SAL 253 Query: 255 IALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRV-QVILPKFTAVAQTDLKEPLKVLGI 313 LP + + + + +T+ W + + P+ + ++ LPKF+ L++ L LGI Sbjct: 254 FILPDQG--RMQQVEASLQPETLRKWKNSLKPRMIDELHLPKFSISTDYSLEDVLSKLGI 311 Query: 314 TDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSS---PPW 370 ++F S++A+ + IT G+++L VS ++ KA ++V+E GT+A+AAT + S+ P Sbjct: 312 REVF-STQADLSAIT-GTKDLRVSQVVHKAVLDVAETGTEAAAATGVKFVPMSAKLYPLT 369 Query: 371 FIVDRPFLFFIRHNPTGAVLFMGQINKP 398 +RPFL I T F+ +I P Sbjct: 370 VYFNRPFLIMIFDTETEIAPFIAKIANP 397 >4P0F-A nrPDB Length = 393 Score = 372 bits (955), Expect = e-103, Method: Composition-based stats. Identities = 113/370 (30%), Positives = 187/370 (50%), Gaps = 13/370 (3%) Query: 34 TGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILK 93 I V+ ++ +P +NIV SP I + M +LGA+ T QL + + +I Sbjct: 17 FSINVYGKLSGQKPGENIVFSPFSIQTCAAMARLGAENETATQLDQGLGLASSDPEQIAH 76 Query: 94 KINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSI 153 ++ + + ++ I+ +AN +FV + ++ F F ++V+F A +I Sbjct: 77 SFHQVLAAYQDSQILRIANKIFVMDGYQLRQEFDQLLSKQFLSAAQSVDFSKNVQAAATI 136 Query: 154 NAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGK 213 N WV+ T +I +L+ D+++ +RLVLVNA++FKG W+ +F T+ TF + Sbjct: 137 NNWVEQRTNHLIKDLVPADVLNSE-SRLVLVNAIHFKGTWQHQFAKHLTRPDTFHLDGER 195 Query: 214 SYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHIS 273 + QVPM++ FR A + + +ELPY +SMLI LP + T L A+ + Sbjct: 196 TVQVPMMSLKERFRYADLPALDAMA---LELPYKDSDLSMLIVLPN-TKTGLPALEEKLR 251 Query: 274 TKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSEN 333 T+ + +V + LP+F A Q +L E + LG++ MF S +A F K+ E Sbjct: 252 LTTLSQITQSLYETKVALKLPRFKAEFQVELSEVFQKLGMSRMF-SDQAEFGKMLQSPEP 310 Query: 334 LHVSHILQKAKIEVSEDGTKASAATTA------ILIARSSPPWFIVDRPFLFFIRHNPTG 387 L VS I+ KA IEV+E+GT+A+AAT +++ P F D PF + + H Sbjct: 311 LKVSAIIHKAFIEVNEEGTEAAAATGMAVRRKRAIMSPEEPIEFFADHPFTYVLVHQKD- 369 Query: 388 AVLFMGQINK 397 LF G + + Sbjct: 370 LPLFWGSVVR 379 >4ZK0-A nrPDB Length = 390 Score = 368 bits (945), Expect = e-102, Method: Composition-based stats. Identities = 121/396 (30%), Positives = 197/396 (49%), Gaps = 31/396 (7%) Query: 26 SLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGV 85 SL E + +F Q KS+ + NI SP I S LGM+ LGA T +Q+ V+ + Sbjct: 3 SLSEANTKFMFDLFQQFRKSKEN-NIFYSPISITSALGMVLLGAKDNTAQQIKKVLHFDQ 61 Query: 86 -----------------NGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVT 128 V +K+ + + +AN +F + ++ Sbjct: 62 VTENTTGKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYLFLQEYLD 121 Query: 129 RNKDVFQCEVRNVNFED-PASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAV 187 K +Q V +V+F + P + IN+WV+++T + I NL+ P+ G T LVLVNA+ Sbjct: 122 AIKKFYQTSVESVDFANAPEESRKKINSWVESQTNEKIKNLI-PEGNIGSNTTLVLVNAI 180 Query: 188 YFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYH 247 YFKG W+ +F E+TK+ F + M+ Q + F S D+ +E+PY Sbjct: 181 YFKGQWEKKFNKEDTKEEKFWPNKNTYKSIQMMRQYTSFHFASLE---DVQAKVLEIPYK 237 Query: 248 GESISMLIALPTESSTPLSAIIPHISTKTIDSW--MSIMVPKRVQVILPKFTAVAQTDLK 305 G+ +SM++ LP E L + ++ + + W + M RV + LP+F DLK Sbjct: 238 GKDLSMIVLLPNE-IDGLQKLEEKLTAEKLMEWTSLQNMRETRVDLHLPRFKVEESYDLK 296 Query: 306 EPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAIL--- 362 + L+ +G+ D+F+ A+ + +T GS L +S +L KA +EV+E+G +A+AAT + Sbjct: 297 DTLRTMGMVDIFNGD-ADLSGMT-GSRGLVLSGVLHKAFVEVTEEGAEAAAATAVVGFGS 354 Query: 363 IARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINKP 398 S+ F + PFLFFIR N T ++LF G+ + P Sbjct: 355 SPTSTNEEFHCNHPFLFFIRQNKTNSILFYGRFSSP 390 >1HLE-A nrPDB Length = 345 Score = 368 bits (944), Expect = e-102, Method: Composition-based stats. Identities = 97/329 (29%), Positives = 161/329 (48%), Gaps = 12/329 (3%) Query: 27 LEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYG-V 85 L ++ + +F + +S P NI ISP I+S L M+ LG G T Q++ + + V Sbjct: 5 LSTANTHFAVDLFRALNESDPTGNIFISPLSISSALAMIFLGTRGNTAAQVSKALYFDTV 64 Query: 86 NGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFED 145 + + +N I I+ +AN ++ + F+ + ++ E+ +V+F+ Sbjct: 65 EDIHSRFQSLNADINKPGAPYILKLANRLYGEKTYNFLADFLASTQKMYGAELASVDFQQ 124 Query: 146 -PASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKK 204 P A IN WVK +T I LL ++D +T+LVLVNA+YFKG W+ +F E T+ Sbjct: 125 APEDARKEINEWVKGQTEGKIPELLVKGMVDN-MTKLVLVNAIYFKGNWQQKFMKEATRD 183 Query: 205 RTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPT---ES 261 F + V M+ Q F DL +ELPY G+ +SM+I LP + Sbjct: 184 APFRLNKKDTKTVKMMYQKKKFPYNYIE---DLKCRVLELPYQGKELSMIILLPDDIEDE 240 Query: 262 STPLSAIIPHISTKTIDSWMS--IMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDS 319 ST L I ++ + W + V V LP+F DL L LG+ D+F+ Sbjct: 241 STGLEKIEKQLTLDKLREWTKPENLYLAEVNVHLPRFKLEESYDLTSHLARLGVQDLFNR 300 Query: 320 SKANFAKITTGSENLHVSHILQKAKIEVS 348 KA+ + ++ G+ +L VS I+ K+ ++++ Sbjct: 301 GKADLSGMS-GARDLFVSKIIHKSFVDLN 328 >1UHG-A nrPDB Length = 385 Score = 364 bits (935), Expect = e-101, Method: Composition-based stats. Identities = 115/391 (29%), Positives = 195/391 (49%), Gaps = 25/391 (6%) Query: 26 SLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYG- 84 S+ VF ++ ++NI P I S L M+ LGA T+ Q+ V+R+ Sbjct: 2 SIGAASMEFCFDVFKELKVHHANENIFYCPIAIMSALAMVYLGAKDSTRTQINKVVRFDK 61 Query: 85 --------------VNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRN 130 V L+ I I + ++A+ ++ + I ++ Sbjct: 62 LPGFGDSIEAQCGTSVNVHSSLRDILNQITKPNDVYSFSLASRLYAEERYPILPEYLQCV 121 Query: 131 KDVFQCEVRNVNFEDPA-SACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYF 189 K++++ + +NF+ A A + IN+WV+++T +I N+L P +D T +VLVNA+ F Sbjct: 122 KELYRGGLEPINFQTAADQARELINSWVESQTNGIIRNVLQPSSVDS-QTAMVLVNAIVF 180 Query: 190 KGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGE 249 KGLW+ F+ E+T+ F + +S V M+ Q+ +FR S ++ +ELP+ Sbjct: 181 KGLWEKAFKDEDTQAMPFRVTEQESKPVQMMYQIGLFRVASMASEK---MKILELPFASG 237 Query: 250 SISMLIALPTESSTPLSAIIPHISTKTIDSWMSI--MVPKRVQVILPKFTAVAQTDLKEP 307 ++SML+ LP E S L + I+ + + W S M ++++V LP+ + +L Sbjct: 238 TMSMLVLLPDEVS-GLEQLESIINFEKLTEWTSSNVMEERKIKVYLPRMKMEEKYNLTSV 296 Query: 308 LKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSS 367 L +GITD+F SS AN + I++ +E+L +S + A E++E G + + A + A S Sbjct: 297 LMAMGITDVFSSS-ANLSGISS-AESLKISQAVHAAHAEINEAGREVVGSAEAGVDAASV 354 Query: 368 PPWFIVDRPFLFFIRHNPTGAVLFMGQINKP 398 F D PFLF I+H T AVLF G+ P Sbjct: 355 SEEFRADHPFLFCIKHIATNAVLFFGRCVSP 385 >4Y40-A nrPDB Length = 414 Score = 363 bits (931), Expect = e-100, Method: Composition-based stats. Identities = 89/375 (23%), Positives = 168/375 (44%), Gaps = 14/375 (3%) Query: 27 LEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRY--- 83 L + G ++ ++ P NI +SP I++ ML LGA T ++ + Sbjct: 48 LARQNMDLGFKLLKKLAFYNPGRNIFLSPLSISTAFSMLCLGAQDSTLDEIKQGFNFRKM 107 Query: 84 GVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNF 143 + + I + K +++ N +F+ + + F+ K+ + E NF Sbjct: 108 PEKDLHEGFHYIIHELTQKTQDLKLSIGNTLFIDQRLQPQRKFLEDAKNFYSAETILTNF 167 Query: 144 EDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTK 203 ++ A IN ++ +T I+NL+ T ++L N ++F+ WK F P TK Sbjct: 168 QNLEMAQKQINDFISQKTHGKINNLIENI---DPGTVMLLANYIFFRARWKHEFDPNVTK 224 Query: 204 KRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESST 263 + F S +VPM+ + +++ G + L +E+PY I+ + LP E Sbjct: 225 EEDFFLEKNSSVKVPMMFRSGIYQVGY---DDKLSCTILEIPYQKN-ITAIFILPDEGK- 279 Query: 264 PLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKAN 323 L + + T W +++ + V V +P+ DLK+ L +G++ +F+ + Sbjct: 280 -LKHLEKGLQVDTFSRWKTLLSRRVVCVSVPRLHMTGTFDLKKTLSYIGVSKIFE-EHGD 337 Query: 324 FAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRH 383 KI +L V + KA++++ E GT+ +A T A + +P +D+P+L I Sbjct: 338 LTKIAPH-RSLKVGEAVHKAELKMDERGTEGAAGTGAQTLPMETPLCVKIDKPYLLLIYS 396 Query: 384 NPTGAVLFMGQINKP 398 +VLF+G+I P Sbjct: 397 EKIPSVLFLGKIVNP 411 >5NCS-A nrPDB Length = 375 Score = 363 bits (931), Expect = e-100, Method: Composition-based stats. Identities = 107/384 (27%), Positives = 193/384 (50%), Gaps = 23/384 (5%) Query: 24 PLSLEELGSN--TGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVM 81 PL E++ + + K N+ ISP ++ L M GA G T ++ + Sbjct: 2 PLGSEKIEKDNAFAFDLLQTTRKHVTEANVFISPLSVSMALNMTLNGAAGVTADEMKTAL 61 Query: 82 R---YGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEV 138 R Y + + + + +A++ + +AN+++ K ++ PF+ N+ + EV Sbjct: 62 RETGYTMEDINEYSHSLREALLKVDPSTTIGMANSIWYKQGELVKEPFILANRTHYDAEV 121 Query: 139 RNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQ 198 + V+F PA +IN W +T D I +L D I G + L+NAVYFKG+W ++F+ Sbjct: 122 KAVDFSSPA-TLPAINGWCAQKTNDKITKIL--DYIPGNA-FMYLINAVYFKGIWVTQFK 177 Query: 199 PENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALP 258 +TK+ F ADG + +V M+AQ S F + D ++E+ Y ++ SM++ LP Sbjct: 178 KSDTKRAPFRKADGTTQEVNMMAQKSTFGYTT-----DECCQYLEMDYGNKAFSMIVMLP 232 Query: 259 TESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDL-KEPLKVLGITDMF 317 E T I + K + + P +V + +P+F + L K+ L +G+ F Sbjct: 233 NEGQTTRDVIEQ-LDNKHWSMIIKGIRPTQVSLRMPRFKTECKYGLEKKILPEMGMNVPF 291 Query: 318 DSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILI----ARSSPPWFIV 373 + A+F IT + + +S ++ K ++V E+GT+A+A T ++ ++P F + Sbjct: 292 -TETADFPGITDAA--IFISRVIHKTFVQVDEEGTEAAAVTAVEMVKTSSPSTTPINFHI 348 Query: 374 DRPFLFFIRHNPTGAVLFMGQINK 397 ++PF+F IR TG +LF+G+I + Sbjct: 349 NKPFVFAIREKSTGVILFIGEIGE 372 >2H4Q-A nrPDB Length = 382 Score = 360 bits (923), Expect = e-100, Method: Composition-based stats. Identities = 102/349 (29%), Positives = 178/349 (51%), Gaps = 16/349 (4%) Query: 25 LSLEELGS---NTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVM 81 +S+E++ + N + +FN++ ++ NI SP I+S L + L A G T +++A V+ Sbjct: 40 ISMEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTAREMAEVL 99 Query: 82 RYGV-NGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRN 140 + + K++ A +N + AN ++V+ + ++ +K ++ E + Sbjct: 100 HFEQAENIHSGFKELLTAFNKPRNNYSLRSANRIYVEKTYALLPTYLQLSKKYYKAEPQK 159 Query: 141 VNFED-PASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQP 199 VNF+ P + IN WV+ +T I NLLS D + TRL+LVNA+YFK W+ +FQ Sbjct: 160 VNFKTAPEQSRKEINTWVEKQTESKIKNLLSSDDVKAT-TRLILVNAIYFKAEWEVKFQA 218 Query: 200 ENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPT 259 E T + F + KS V M+ F N + IELPY +SM I LP Sbjct: 219 EKTSIQPFRLSKNKSKPVKMMYMRDTFPVLIMEKMN---FKMIELPYVKRELSMFILLPD 275 Query: 260 ---ESSTPLSAIIPHISTKTIDSWMSI--MVPKRVQVILPKFTAVAQTDLKEPLKVLGIT 314 + +T L + ++ + + W M V + LPKF+ + DL++ L+ +G+T Sbjct: 276 DIKDGTTGLEQLERELTYERLSEWADSKMMTETLVDLHLPKFSLEDRIDLRDTLRNMGMT 335 Query: 315 DMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILI 363 F ++ A+F +T ++L +S ++ ++ + V E GT+A AAT I+ Sbjct: 336 TAFTTN-ADFRGMT-DKKDLAISKVIHQSFVAVDEKGTEAVAATAVIIS 382 >3DY0-A nrPDB Length = 336 Score = 356 bits (915), Expect = 6e-99, Method: Composition-based stats. Identities = 86/336 (25%), Positives = 169/336 (50%), Gaps = 16/336 (4%) Query: 33 NTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVN-----G 87 + ++ + + P NI SP I+ L ML LGA TK Q+ + + Sbjct: 11 DFTFDLYRALASAAPSQNIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKSSEKE 70 Query: 88 VGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPA 147 + + +++ + + ++ +++ NA+F +++ FV+ K ++ + NF D A Sbjct: 71 LHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPTNFRDSA 130 Query: 148 SACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTF 207 A IN +V +T+ I +LL + V+ ++VN ++FK W++ F + T+++ F Sbjct: 131 GAMKQINDYVAKQTKGKIVDLLKNLDSNAVV---IMVNYIFFKAKWETSFNHKGTQEQDF 187 Query: 208 VAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSA 267 +VPM+++ + +L + +PY G + ++ I LP+E + Sbjct: 188 YVTSETVVRVPMMSREDQYHY---LLDRNLSCRVVGVPYQGNATALFI-LPSEGK--MQQ 241 Query: 268 IIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKI 327 + +S KT+ W+ + +++++ LPKF+ L++ L LGI+++F S A+ + I Sbjct: 242 VENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTS-HADLSGI 300 Query: 328 TTGSENLHVSHILQKAKIEVSEDGTKASAATTAILI 363 + S N+ VS ++ KA +EV E GT+A+AAT I Sbjct: 301 SNHS-NIQVSEMVHKAVVEVDESGTRAAAATGTIFT 335 >3NDA-A nrPDB Length = 377 Score = 356 bits (914), Expect = 9e-99, Method: Composition-based stats. Identities = 119/381 (31%), Positives = 199/381 (52%), Gaps = 21/381 (5%) Query: 27 LEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGV- 85 L + + G+++ + S P N+ SP+ +++ +GM GA G+T+++L+ + + Sbjct: 7 LTKANNRFGLRLLRAL-PSGPEKNVFFSPYSVSTAMGMAFAGARGQTQQELSQGLGFSDV 65 Query: 86 ----NGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNV 141 GV + + S + + VANA ++ + + + + F E+ V Sbjct: 66 DLTDAGVLDAYTHHTERLKSTPSNSTLDVANAAAIQRTLALLNSYESALQSSFGAELHKV 125 Query: 142 NF-EDPASACDSINAWVKNETRDMIDNLL-SPDLIDGVLTRLVLVNAVYFKGLWKSRFQP 199 +F +P +A D +N WVK +T D I+ L P D T LVL+NA+YFKG W + F Sbjct: 126 DFAGEPQAAVDFVNNWVKRKTHDKIEKLFNEPLDPD---TLLVLLNAIYFKGEWNTAFVK 182 Query: 200 ENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPT 259 E+T+KR F +V + + + +DL +ELPY G +M I LP Sbjct: 183 EHTEKRQFFNGGVTPVEVDTMRLEARIKYRFF---DDLQVEVVELPYRGLDYTMAILLPK 239 Query: 260 ESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDS 319 E +T + + +++ +++S + +++ V+LPKF + LK PL+ LGI +F+S Sbjct: 240 E-NTGVEGLKQNLTIDRFQNYLSDLRERKITVLLPKFKLETKYSLKAPLQSLGIKQIFES 298 Query: 320 SKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARS---SPPWFIVDRP 376 A+ + I GS L VS + KA +EV+E+GT A+A T +++ S P F VD P Sbjct: 299 G-ADLSGINDGS--LRVSAVEHKAVVEVNEEGTVAAATTGVVIVPYSLGPEPVVFRVDHP 355 Query: 377 FLFFIRHNPTGAVLFMGQINK 397 FLFFIR+ T + F+GQ+NK Sbjct: 356 FLFFIRNTRTDDIFFVGQVNK 376 >4AJT-A nrPDB Length = 427 Score = 356 bits (914), Expect = 1e-98, Method: Composition-based stats. Identities = 102/378 (26%), Positives = 191/378 (50%), Gaps = 17/378 (4%) Query: 27 LEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVN 86 L S+ G + +I R N++ SP G++ + L LG G TK Q+ + Sbjct: 58 LSNETSSFGFNLLRKI-SMRHDGNVIFSPFGLSVAMVNLMLGTKGETKVQIENGLNLQAL 116 Query: 87 G------VGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRN 140 + + KK+ + S ++ ++ + F+ +I+ + +K F E + Sbjct: 117 SQAGPLILPALFKKVKETFSSNRDLG-LSQGSFAFIHKDFDIKETYFNLSKKYFDIEYVS 175 Query: 141 VNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPE 200 +NF++ + A IN + ET I L T+L+LV+ V FKG W + F P Sbjct: 176 INFQNSSQARGLINHCIVKETEGKIPKLFDEI---NPETKLILVDYVLFKGKWLTPFDPS 232 Query: 201 NTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTE 260 T+ TF ++ +VPM+ + F +++ + ++LPY G + +ML+ L + Sbjct: 233 FTEADTFHLDKYRAIKVPMMYREGNF---TSTFDKKFRCHILKLPYQGNA-TMLVVLMEK 288 Query: 261 SSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSS 320 + L A+ +++ +++W+ M ++++V PKF + ++ E LK +GI +F +S Sbjct: 289 TGDYL-ALEDYLTVDLVETWLQNMKTRKMEVFFPKFKLNQRYEMHELLKQMGIRRLFSTS 347 Query: 321 KANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFF 380 A+ ++++ + NL VS +LQ++ +EV E GT+A + T + +IA S PP V+RPF F Sbjct: 348 -ADLSELSAMARNLQVSRVLQQSVLEVDERGTEAVSGTLSEIIAYSMPPAIKVNRPFHFI 406 Query: 381 IRHNPTGAVLFMGQINKP 398 I + +LF+G++ P Sbjct: 407 IYEEMSRMLLFLGRVVNP 424 >3F02-A nrPDB Length = 359 Score = 355 bits (911), Expect = 2e-98, Method: Composition-based stats. Identities = 113/344 (32%), Positives = 202/344 (58%), Gaps = 10/344 (2%) Query: 28 EELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNG 87 EE ++ + ++N++ + +NI+ SP IA +GM++LGA G T+K++ M Y Sbjct: 20 EEAIADLSVNMYNRLRATGEDENILFSPLSIALAMGMMELGAQGSTQKEIRHSMGYDSLK 79 Query: 88 VGK---ILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFE 144 G+ LK+ + + +K+++ ++ +AN++FV+N + F+ K F V +V+F Sbjct: 80 NGEEFSFLKEFSNMVTAKESQYVMKIANSLFVQNGFHVNEEFLQMMKKYFNAAVNHVDFS 139 Query: 145 DPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKK 204 + + IN WV+N T +++ +L+SP D T L L+NAVYFKG WKS+F+PENT+ Sbjct: 140 QNVAVANYINKWVENNTNNLVKDLVSPRDFDAA-TYLALINAVYFKGNWKSQFRPENTRT 198 Query: 205 RTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLW---YNFIELPYHGESISMLIALPTES 261 +F D Q+PM+ Q F G S ++ Y +E+PY G+ ISM++ L + Sbjct: 199 FSFTKDDESEVQIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLVL-SRQ 257 Query: 262 STPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSK 321 PL+ + P + + ++ W + + ++V+V LP+FT + DLK+ LK LGIT++F Sbjct: 258 EVPLATLEPLVKAQLVEEWANSVKKQKVEVYLPRFTVEQEIDLKDVLKALGITEIF-IKD 316 Query: 322 ANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIAR 365 AN ++ ++ + +S + K+ +EV+E+G++A+A + I I+R Sbjct: 317 ANLTGLS-DNKEIFLSKAIHKSFLEVNEEGSEAAAVSGMIAISR 359 >2H4P-A nrPDB Length = 394 Score = 352 bits (904), Expect = 1e-97, Method: Composition-based stats. Identities = 104/382 (27%), Positives = 181/382 (47%), Gaps = 44/382 (11%) Query: 20 SHFNPLSLEELGS---NTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQ 76 SH +S+E++ + N + +FN++ ++ NI SP I+S L + L A G T ++ Sbjct: 19 SHELEISMEQVSASIGNFTVDLFNKLNETNRDKNIFFSPWSISSALALTYLAAKGSTARE 78 Query: 77 LAMVMRYG-----------------------------VNGVGKILKKINKAIVSKKNKDI 107 +A V+ + + K++ A +N Sbjct: 79 MAEVLHFTEAVRAESSSVARPSRGRPKRRRMDPEHEQAENIHSGFKELLTAFNKPRNNYS 138 Query: 108 VTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFED-PASACDSINAWVKNETRDMID 166 + AN ++V+ + ++ +K ++ E + VNF+ P + IN WV+ +T I Sbjct: 139 LRSANRIYVEKTYALLPTYLQLSKKYYKAEPQKVNFKTAPEQSRKEINTWVEKQTESKIK 198 Query: 167 NLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVF 226 NLLS D + TRL+LVNA+YFK W+ +FQ E T + F + KS V M+ F Sbjct: 199 NLLSSDDVKAT-TRLILVNAIYFKAEWEVKFQAEKTSIQPFRLSKNKSKPVKMMYMRDTF 257 Query: 227 RCGSTSAPNDLWYNFIELPYHGESISMLIALPT---ESSTPLSAIIPHISTKTIDSWMSI 283 N + IELPY +SM I LP + +T L + ++ + + W Sbjct: 258 PVLIMEKMN---FKMIELPYVKRELSMFILLPDDIKDGTTGLEQLERELTYERLSEWADS 314 Query: 284 --MVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQ 341 M V + LPKF+ + DL++ L+ +G+T F ++ A+F +T ++L +S ++ Sbjct: 315 KMMTETLVDLHLPKFSLEDRIDLRDTLRNMGMTTAFTTN-ADFRGMT-DKKDLAISKVIH 372 Query: 342 KAKIEVSEDGTKASAATTAILI 363 ++ + V E GT+A+AAT I+ Sbjct: 373 QSFVAVDEKGTEAAAATAVIIS 394 >1JMJ-A nrPDB Length = 480 Score = 351 bits (900), Expect = 4e-97, Method: Composition-based stats. Identities = 96/380 (25%), Positives = 183/380 (48%), Gaps = 23/380 (6%) Query: 30 LGSNTGIQVFNQIVKS-RPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRY----- 83 L + ++ + DNI I+P GI++ +GM+ LG G T +Q+ ++ + Sbjct: 110 LNAKFAFNLYRVLKDQVNTFDNIFIAPVGISTAMGMISLGLKGETHEQVHSILHFKDFVN 169 Query: 84 -----GVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEV 138 + + + +K+ + + + N ++++ I + F T+ ++ + E Sbjct: 170 ASSKYEITTIHNLFRKLTHRLFRRNFGYTLRSVNDLYIQKQFPILLDFKTKVREYYFAEA 229 Query: 139 RNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQ 198 + +F DPA + N + T+ +I + L T+++++N +YFKG W ++F Sbjct: 230 QIADFSDPAFISKT-NNHIMKLTKGLIKDALENI---DPATQMMILNCIYFKGSWVNKFP 285 Query: 199 PENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALP 258 E T F + + +V M+ F + +L + ++L Y G ISMLI +P Sbjct: 286 VEMTHNHNFRLNEREVVKVSMMQTKGNFLAAN---DQELDCDILQLEYVG-GISMLIVVP 341 Query: 259 TESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFD 318 + S + + ++ + ++ W M + +V+LPKF +L E LK++GI +FD Sbjct: 342 HKMS-GMKTLEAQLTPRVVERWQKSMTNRTREVLLPKFKLEKNYNLVESLKLMGIRMLFD 400 Query: 319 SSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFL 378 + N A I+ + + + + I V+E+GT+A+ TT + S+ F VDRPFL Sbjct: 401 KN-GNMAGIS--DQRIAIDLFKHQGTITVNEEGTQATTVTTVGFMPLSTQVRFTVDRPFL 457 Query: 379 FFIRHNPTGAVLFMGQINKP 398 F I + T +LFMG++ P Sbjct: 458 FLIYEHRTSCLLFMGRVANP 477 >6F02-A nrPDB Length = 389 Score = 346 bits (889), Expect = 8e-96, Method: Composition-based stats. Identities = 96/388 (24%), Positives = 177/388 (45%), Gaps = 22/388 (5%) Query: 23 NPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMR 82 L + ++ + + I P NI SP I++ ML LGA ++ Q+ + Sbjct: 3 PSLKIAPANADFAFRFYYLIASETPGKNIFFSPLSISAAYAMLSLGACSHSRSQILEGLG 62 Query: 83 YGVN-----GVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCE 137 + + V + + + + + V +A+F+ + + F+ V++ + Sbjct: 63 FNLTELSESDVHRGFQHLLHTLNLPGHGLETRVGSALFLSHNLKFLAKFLNDTMAVYEAK 122 Query: 138 VRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRF 197 + + NF D IN VK ETR I +L+S D + +VLVN +YFK LW+ F Sbjct: 123 LFHTNFYDTVGTIQLINDHVKKETRGKIVDLVSELKKDVL---MVLVNYIYFKALWEKPF 179 Query: 198 QPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIAL 257 T + F + + +VPM+ Q L + + + Y G++ ++ L Sbjct: 180 ISSRTTPKDFYVDENTTVRVPMMLQDQEHHW--YLHDRYLPCSVLRMDYKGDA-TVFFIL 236 Query: 258 PTESSTPLSAIIPHISTKTIDSWMSIMVPK----RVQVILPKFTAVAQTDLKEPLKVLGI 313 P + + I ++ + + W +++ + ++++ LPKF+ L + L LG Sbjct: 237 PNQGK--MREIEEVLTPEMLMRWNNLLRKRNFYKKLELHLPKFSISGSYVLDQILPRLGF 294 Query: 314 TDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAIL---IARSSPPW 370 TD+F S A+ + IT + L S KA ++V E GT+A+AAT+ + A+++ Sbjct: 295 TDLF-SKWADLSGITK-QQKLEASKSFHKATLDVDEAGTEAAAATSFAIKFFSAQTNRHI 352 Query: 371 FIVDRPFLFFIRHNPTGAVLFMGQINKP 398 +RPFL I T +VLF+G++ P Sbjct: 353 LRFNRPFLVVIFSTSTQSVLFLGKVVDP 380 >2XN5-A nrPDB Length = 350 Score = 340 bits (873), Expect = 5e-94, Method: Composition-based stats. Identities = 81/351 (23%), Positives = 166/351 (47%), Gaps = 17/351 (4%) Query: 27 LEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVN 86 + + ++ ++ + P NI SP I++ L ML GA T+ ++ + + + Sbjct: 11 MSSINADFAFNLYRRFTVETPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLT 70 Query: 87 G-----VGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNV 141 + + + ++ K + + + NA+F+ + F+ K +++ EV + Sbjct: 71 DTPMVEIQHGFQHLICSLNFPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFST 130 Query: 142 NFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPEN 201 +F + ++A IN+ V+ +T+ + L+ + T +VLVN ++FK W + F P Sbjct: 131 DFSNISAAKQEINSHVEMQTKGKVVGLIQDLKPN---TIMVLVNYIHFKAQWANPFDPSK 187 Query: 202 TKK-RTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTE 260 T+ +F+ + QVPM+ Q+ + +L +++ Y ++++ + LP E Sbjct: 188 TEDSSSFLIDKTTTVQVPMMHQMEQYYH---LVDMELNCTVLQMDYSKNALALFV-LPKE 243 Query: 261 SSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSS 320 + ++ +S+KT+ W ++ V + +PKF+ A DL L +GI + S Sbjct: 244 GQ--MESVEAAMSSKTLKKWNRLLQKGWVDLFVPKFSISATYDLGATLLKMGIQHAY-SE 300 Query: 321 KANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWF 371 A+F+ +T + L +S+ KA + + E GT+A+ A I RS P F Sbjct: 301 NADFSGLTEDNG-LKLSNAAHKAVLHIGEKGTEAAGAMFLEAIPRSIPNTF 350 >2V95-A nrPDB Length = 371 Score = 338 bits (868), Expect = 2e-93, Method: Composition-based stats. Identities = 90/378 (23%), Positives = 175/378 (46%), Gaps = 20/378 (5%) Query: 26 SLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGV 85 L + ++ ++V P N +ISP I+ L M+ LG+ + Q + + + Sbjct: 8 GLAPTNVDFAFNLYQRLVALNPDKNTLISPVSISMALAMVSLGSA---QTQSLQSLGFNL 64 Query: 86 NG-----VGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRN 140 + + + +N + + + NA+F+ +++ F+ K ++ E Sbjct: 65 TETSEAEIHQSFQYLNYLLKQSDTGLEMNMGNAMFLLQKLKLKDSFLADVKQYYESEALA 124 Query: 141 VNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPE 200 ++FED A IN VK++T+ I+++ S +LVN ++ +G+W+ F PE Sbjct: 125 IDFEDWTKASQQINQHVKDKTQGKIEHVFSDLDSPASF---ILVNYIFLRGIWELPFSPE 181 Query: 201 NTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTE 260 NT++ F + + +VPM+ Q S I++ Y G + I LP + Sbjct: 182 NTREEDFYVNETSTVKVPMMVQSGSIGYFRDSV---FPCQLIQMDYVGNGTAFFI-LPDQ 237 Query: 261 SSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSS 320 + +I +S TID W +M P++V + +PKF+ DLK+ L+ L I D+ ++ Sbjct: 238 GQ--MDTVIAALSRDTIDRWGKLMTPRQVNLYIPKFSMSDTYDLKDVLEDLNIKDLL-TN 294 Query: 321 KANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFF 380 +++F+ T L ++ ++ KA +++ E ++ A L RS P ++PF+ Sbjct: 295 QSDFSG-NTKDVPLTLT-MVHKAMLQLDEGNVLPNSTNGAPLHLRSEPLDIKFNKPFILL 352 Query: 381 IRHNPTGAVLFMGQINKP 398 + T + L M Q+ P Sbjct: 353 LFDKFTWSSLMMSQVVNP 370 >1XQJ-A nrPDB Length = 389 Score = 334 bits (857), Expect = 4e-92, Method: Composition-based stats. Identities = 91/379 (24%), Positives = 182/379 (48%), Gaps = 14/379 (3%) Query: 27 LEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRY-GV 85 L+ S + +F Q+ + P N++ SP +++ L + Q+GA G T ++ V+ + V Sbjct: 18 LQLANSAFAVDLFKQLSEKEPLGNVLFSPIALSTSLSLAQVGAKGDTANEIGQVLHFENV 77 Query: 86 NGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFED 145 V + + + + + + ++V + + F++ K + E+ V+F+D Sbjct: 78 KDVPFGFQTVTSDVNKLSSFYSLKLIKRLYVDKSLNLSTEFISSTKRPYAKELETVDFKD 137 Query: 146 P-ASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKK 204 IN +K+ T +N+L+ + ++ T++++VNA YF G W +F TK+ Sbjct: 138 KLEETKGQINNSIKDLTDGHFENILADNSVND-QTKILVVNAAYFVGKWMKKFSESETKE 196 Query: 205 RTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALP---TES 261 F + V M+ + F G+ + N IELP+ + +SM I LP + Sbjct: 197 SPFRVNKTDTKPVQMMNMEATFSMGNIDSINS---KIIELPFQNKHLSMFILLPKDVEDE 253 Query: 262 STPLSAIIPHISTKTIDSWMS--IMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDS 319 ST L I ++++++ W + M +V++ +PKF D K L+ LG+ +F Sbjct: 254 STGLEKIEKQLNSESLSQWTNPSTMANAKVKLSIPKFKVEKMIDPKASLENLGLKHIFSE 313 Query: 320 SKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLF 379 ++F+ ++ + +S+++ K +E++EDG + A ++ D PF++ Sbjct: 314 DTSDFSGMSETKG-VALSNVIHKVSLEITEDGGDSIEVPGARILQHKD--ELNADHPFIY 370 Query: 380 FIRHNPTGAVLFMGQINKP 398 IRHN T ++F G+ + P Sbjct: 371 IIRHNKTRNIIFFGKFSSP 389 >1QMB-A nrPDB Length = 326 Score = 334 bits (857), Expect = 4e-92, Method: Composition-based stats. Identities = 78/333 (23%), Positives = 149/333 (44%), Gaps = 18/333 (5%) Query: 32 SNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGV--- 88 + ++ Q+ NI SP IA+ ML LG T ++ + + + + Sbjct: 7 AEFAFSLYRQLAHQS-STNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEA 65 Query: 89 --GKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDP 146 + +++ + + ++ +T N +F+ ++ F+ K ++ E VNF D Sbjct: 66 AIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDT 125 Query: 147 ASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRT 206 A IN +V+ T+ I +L+ D T LVN ++FKG W+ F+ ++T++ Sbjct: 126 EEAKKQINDYVEKGTQGKIVDLVKELDRD---TVFALVNYIFFKGKWERPFEVKDTEEED 182 Query: 207 FVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLS 266 F + +VPM+ +L +F + L + + Y G + ++ LP E L Sbjct: 183 FHVDQVTTVKVPMMKRLGMF---NIQHCKKLSSWVLLMKYLGNATAIFF-LPDEGK--LQ 236 Query: 267 AIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAK 326 + ++ I ++ + + LPK + DLK L LGIT +F S+ A+ + Sbjct: 237 HLENELTHDIITKFLEN-DRRSASLHLPKLSITGTYDLKSVLGQLGITKVF-SNGADLSG 294 Query: 327 ITTGSENLHVSHILQKAKIEVSEDGTKASAATT 359 +T + L +S + KA + + E GT+A+ A Sbjct: 295 VTEEA-PLKLSKAVHKAVLTIDEKGTEAAGAMF 326 >1K9O-I nrPDB Length = 378 Score = 333 bits (854), Expect = 8e-92, Method: Composition-based stats. Identities = 118/376 (31%), Positives = 190/376 (50%), Gaps = 12/376 (3%) Query: 27 LEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVN 86 L E Q+F+++VK+ P N+V+S + LG L L + G + +L + + Sbjct: 11 LRESNDQFTAQMFSEVVKANPGQNVVLSAFSVLPPLGQLALASVGESHDELLRALALPND 70 Query: 87 GVGK-ILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFED 145 V K + +N+ + + K D + +A+ ++V E+ F ++DVF EV+NV+F Sbjct: 71 NVTKDVFADLNRGVRAVKGVD-LKMASKIYVAKGLELNDDFAAVSRDVFGSEVQNVDFVK 129 Query: 146 PASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKR 205 A +IN WV+++T + I NL+ PD +D TR VLVNA+YFKG WK +F E T R Sbjct: 130 SVEAAGAINKWVEDQTNNRIKNLVDPDALDET-TRSVLVNAIYFKGSWKDKFVKERTMDR 188 Query: 206 TFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPL 265 F + K+ +VP + R +L IE+ Y G+ SM+I LP + + Sbjct: 189 DFHVSKDKTIKVPTMIGKKDVRYADVP---ELDAKMIEMSYEGDQASMIIILPNQV-DGI 244 Query: 266 SAIIPHI-STKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANF 324 +A+ + K + + V++ LPKF TDLKE L + I +F A Sbjct: 245 TALEQKLKDPKALSRAEERLYNTEVEITLPKFKIETTTDLKEVLSNMNIKKLFTPGAARL 304 Query: 325 AKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARS--SPPWFIVDRPFLFFIR 382 + E+L V +QKA IEV+E+G +A+AA ++ +S P +DRPF F + Sbjct: 305 ENLLKTKESLTVDAAIQKAFIEVNEEGAEAAAANAFGIVPKSLILYPEVHIDRPFYFEL- 363 Query: 383 HNPTGAVLFMGQINKP 398 G +F G++ +P Sbjct: 364 -KIDGIPMFNGKVIEP 378 >1SEK-A nrPDB Length = 378 Score = 326 bits (837), Expect = 9e-90, Method: Composition-based stats. Identities = 116/376 (30%), Positives = 189/376 (50%), Gaps = 12/376 (3%) Query: 27 LEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVN 86 L E Q+F+++VK+ P N+V+S + LG L L + G + +L + + Sbjct: 11 LRESNDQFTAQMFSEVVKANPGQNVVLSAFSVLPPLGQLALASVGESHDELLRALALPND 70 Query: 87 GVGK-ILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFED 145 V K + +N+ + + K D + +A+ ++V E+ F ++DVF EV+NV+F Sbjct: 71 NVTKDVFADLNRGVRAVKGVD-LKMASKIYVAKGLELNDDFAAVSRDVFGSEVQNVDFVK 129 Query: 146 PASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKR 205 A +IN WV+++T + I NL+ PD +D TR VLVNA+YFKG WK +F E T R Sbjct: 130 SVEAAGAINKWVEDQTNNRIKNLVDPDALDET-TRSVLVNAIYFKGSWKDKFNKERTMDR 188 Query: 206 TFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPL 265 F + K+ +VP + R +L IE+ Y G+ SM+I LP + + Sbjct: 189 DFHVSKDKTIKVPTMIGKKDVRYADVP---ELDAKMIEMSYEGDQASMIIILPNQV-DGI 244 Query: 266 SAIIPHI-STKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANF 324 +A+ + K + + V++ LPKF TDLKE L + I +F A Sbjct: 245 TALEQKLKDPKALSRAEERLYNTEVEIYLPKFKIETTTDLKEVLSNMNIKKLFTPGAARL 304 Query: 325 AKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARS--SPPWFIVDRPFLFFIR 382 + E+L+V +QKA IEV+E+G +A+AA + S P +++PF F ++ Sbjct: 305 ENLLKTKESLYVDAAIQKAFIEVNEEGAEAAAANAFKITTYSFHFVPKVEINKPFFFSLK 364 Query: 383 HNPTGAVLFMGQINKP 398 +N +F G +P Sbjct: 365 YNR--NSMFSGVCVQP 378 >3ZHA-A nrPDB Length = 392 Score = 326 bits (836), Expect = 1e-89, Method: Composition-based stats. Identities = 89/378 (23%), Positives = 172/378 (45%), Gaps = 15/378 (3%) Query: 26 SLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGV 85 +L E + ++ + K + +NI++SP +AS LG++ LG T Q V+ Sbjct: 8 TLAERSAGLAFSLYQAMAKDQAVENILLSPVVVASSLGLVSLGGKATTASQAKAVLSAEQ 67 Query: 86 ---NGVGKILKKINKAIVSKKNKDIV-TVANAVFVKNASEIEVPFVTRNKDVFQCEVRNV 141 V L ++ +++ + +++ + + ++ ++ FV +K + CE + Sbjct: 68 LRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFAEDFVRSSKQHYNCEHSKI 127 Query: 142 NFEDPASACDSINAWVKNETRDMIDNLLSP-DLIDGVLTRLVLVNAVYFKGLWKSRFQPE 200 NF D SA SIN W T + + + DG +LVNA++FK W +F + Sbjct: 128 NFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGA----LLVNAMFFKPHWDEKFHHK 183 Query: 201 NTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTE 260 R F+ + V M+ + ++ +E+P + S++I +P Sbjct: 184 MVDNRGFMVTRSYTVGVTMMHRTGLYNYYDDEKEK---LQIVEMPLAHKLSSLIILMPHH 240 Query: 261 SSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSS 320 PL + ++ + + WM M K V + LPK DL++ L LG+T+ D + Sbjct: 241 VE-PLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKN 299 Query: 321 KANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFF 380 KA+ ++++ G ++L+++ + E +G RS P F D PF+F Sbjct: 300 KADLSRMS-GKKDLYLASVFHATAFEWDTEGNPFDQDIYGREELRS-PKLFYADHPFIFL 357 Query: 381 IRHNPTGAVLFMGQINKP 398 +R +G++LF+G++ +P Sbjct: 358 VRDTQSGSLLFIGRLVRP 375 >5NCU-A nrPDB Length = 336 Score = 324 bits (831), Expect = 4e-89, Method: Composition-based stats. Identities = 94/346 (27%), Positives = 170/346 (49%), Gaps = 19/346 (5%) Query: 24 PLSLEELGSN--TGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVM 81 PL E++ + + K N+ ISP ++ L M GA G T ++ + Sbjct: 2 PLGSEKIEKDNAFAFDLLQTTRKHVTEANVFISPLSVSMALNMTLNGAAGVTADEMKTAL 61 Query: 82 R---YGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEV 138 R Y + + + + +A++ + +AN+++ K ++ PF+ N+ + EV Sbjct: 62 RETGYTMEDINEYSHSLREALLKVDPSTTIGMANSIWYKQGELVKEPFILANRTHYDAEV 121 Query: 139 RNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQ 198 + V+F PA +IN W +T D I +L D I G + L+NAVYFKG+W ++F+ Sbjct: 122 KAVDFSSPA-TLPAINGWCAQKTNDKITKIL--DYIPGNA-FMYLINAVYFKGIWVTQFK 177 Query: 199 PENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALP 258 +TK+ F ADG + +V M+AQ S F + D ++E+ Y ++ SM++ LP Sbjct: 178 KSDTKRAPFRKADGTTQEVNMMAQKSTFGYTT-----DECCQYLEMDYGNKAFSMIVMLP 232 Query: 259 TESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDL-KEPLKVLGITDMF 317 E T I + K + + P +V + +P+F + L K+ L +G+ F Sbjct: 233 NEGQTTRDVIEQ-LDNKHWSMIIKGIRPTQVSLRMPRFKTECKYGLEKKILPEMGMNVPF 291 Query: 318 DSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILI 363 + A+F IT + + +S ++ K ++V E+GT+A+A T ++ Sbjct: 292 -TETADFPGITDAA--IFISRVIHKTFVQVDEEGTEAAAVTAVEMV 334 >6CJ7-A nrPDB Length = 390 Score = 320 bits (821), Expect = 6e-88, Method: Composition-based stats. Identities = 106/372 (28%), Positives = 188/372 (50%), Gaps = 10/372 (2%) Query: 30 LGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVG 89 ++ G+ VF Q+ + N+ SP I +L MLQ GA G T ++ ++ Sbjct: 16 ASTSFGVNVFKQMATEQ-SGNLAASPFSITILLAMLQQGAAGNTLDEITRALQMTPEKSA 74 Query: 90 KILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASA 149 +I KK+N+ I + +++I+ AN VF+ + F + F ++ F PA A Sbjct: 75 EIFKKVNEEIQKRNSRNILKTANNVFLSENFNLNPQFKRIAVNNFDSDLTPTYFGKPALA 134 Query: 150 CDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVA 209 +IN+W+ ++T D ID L+SPD + G T++V+VNAVYFKGLW+ F+ + T+KR F Sbjct: 135 AQNINSWIASKTNDKIDKLVSPDDLSGN-TQMVMVNAVYFKGLWEIPFREQATQKRNFTL 193 Query: 210 ADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAII 269 G+ + F+ G+ + LP+ S+++ LP + S+ + A++ Sbjct: 194 NGGEKKVASFMQTRRYFKAGTH---KPAMAKVVVLPFEYNEYSLIVVLPLK-SSNVDALL 249 Query: 270 PHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITT 329 +S + + S++ + PK V + LPKF+ A +L+ L +G++ +F + + Sbjct: 250 SSLSMEDVASFLD-LPPKDVALELPKFSIKADINLEPVLNKMGVSSIFTQQAELYNLGSH 308 Query: 330 GSENLHVSHILQKAKIEVSEDG--TKASAATTAILIARSSP-PWFIVDRPFLFFIRHNPT 386 GS + VS L A + + E G A+ + A+ ++ P +F ++PFL + N + Sbjct: 309 GSLSPQVSSALHSAVLTIDERGGSAAAATSFAAVALSYDEPSLYFRANKPFLAILWDNRS 368 Query: 387 GAVLFMGQINKP 398 LFM +I P Sbjct: 369 SIPLFMARIMDP 380 >2R9Y-A nrPDB Length = 430 Score = 318 bits (815), Expect = 3e-87, Method: Composition-based stats. Identities = 95/383 (24%), Positives = 173/383 (45%), Gaps = 19/383 (4%) Query: 17 SICSHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQ 76 S+ + L + +F+ + ++ N+V+SP +A L L LGA +T Sbjct: 11 SVPTAEETRRLAQAMMAFTTDLFSLVAQTSTSSNLVLSPLSVALALSHLALGAQNQTLHS 70 Query: 77 LAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQC 136 L V+ G L + + +A ++++ I+ F+ +++ +F Sbjct: 71 LHRVLHMNT---GSCLPHLLSHFYQNLGPGTIRLAARIYLQKGFPIKDDFLEQSERLFGA 127 Query: 137 EVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSR 196 + + +IN WVK T I++ LS T L+L+NA++F G W+++ Sbjct: 128 KPVKLT-GKQEEDLANINQWVKEATEGKIEDFLSEL---PDSTVLLLLNAIHFHGFWRTK 183 Query: 197 FQPENTKKRTFVAADGKSYQVPMLAQLSV-FRCGSTSAPNDLWYNFIELPYHGESISMLI 255 F P T+K F + + V M+ +S R P P+ +S ++ Sbjct: 184 FDPSLTQKDFFHLDERFTVSVDMMHAVSYPLRWFLLEQPE---IQVAHFPFKNN-MSFVV 239 Query: 256 ALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITD 315 +PT +S ++ +++ T+ + + + +V LPK Q DL L LG+ + Sbjct: 240 VMPTYFEWNVSEVLANLTWDTL--YHPSLQERPTKVWLPKLHLQQQLDLVATLSQLGLQE 297 Query: 316 MFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDR 375 +F + I+ +NL VS + ++ +E+SE G +A+AAT+ + R S F V+R Sbjct: 298 LFQGP--DLRGISE--QNLVVSSVQHQSTMELSEAGVEAAAATSV-AMNRMSLSSFTVNR 352 Query: 376 PFLFFIRHNPTGAVLFMGQINKP 398 PFLFFI + G LF+G + P Sbjct: 353 PFLFFIMEDTIGVPLFVGSVRNP 375 >5INW-A nrPDB Length = 421 Score = 317 bits (813), Expect = 5e-87, Method: Composition-based stats. Identities = 102/350 (29%), Positives = 174/350 (49%), Gaps = 20/350 (5%) Query: 27 LEELGSNTGIQVFNQIVK-SRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGV 85 + + G +++ Q++ + P DNI SP IAS LG++ GA+G T+ +L + + Sbjct: 81 IASAVNGLGFRLYKQVLGGAGPADNIFFSPLSIASALGVVTAGANGSTRAELDTALGFKE 140 Query: 86 -------NGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEV 138 K ++N A+ + + N VF K + F +F+ V Sbjct: 141 FLHGKKKAKSMKYFARLNGALYKRSAGFELMGKNVVFSKKGLWLYRQFTRTVAHLFKSNV 200 Query: 139 RNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQ 198 R+V+F D +A + +NA+++ T +++S D T LV+VN +YFKG W ++F+ Sbjct: 201 RSVDFGDSKNAVELMNAYIEKVTSKKFPDVISDVDTD---TSLVIVNVIYFKGSWGNKFE 257 Query: 199 PENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALP 258 P+ TK F S VP + Q + + L ++LPY G + SML+ +P Sbjct: 258 PDLTKNVRFWVNSSYSMMVPTMHQRAKLSY---TQDRKLRSTVVKLPYEGGA-SMLVIVP 313 Query: 259 TESSTPLSAIIPHISTKTIDSWMSIMVPKR--VQVILPKFTAVAQTDLKEPLKVLGITDM 316 + L + +S + ++ W+S++ P VQ+ LPKF DLK L +G++ M Sbjct: 314 HRTED-LPKVEESVSQEQLEEWLSLLGPSNHYVQLSLPKFKISVSYDLKAYLSAMGMSSM 372 Query: 317 FDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARS 366 F S A+ ++IT G + LHV I K+ + V+E+GT+A A T ++A Sbjct: 373 F-SYGADLSRIT-GMQKLHVDKITHKSVLHVNEEGTEAKAETVVGIMAAP 420 >4AJU-A nrPDB Length = 387 Score = 317 bits (812), Expect = 7e-87, Method: Composition-based stats. Identities = 93/344 (27%), Positives = 168/344 (48%), Gaps = 15/344 (4%) Query: 27 LEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRY--- 83 L + SN G + +I R N+V SP G++ + L LGA G T+ Q+ + Sbjct: 54 LAKETSNFGFSLLRKI-SMRHDGNMVFSPFGMSLAMTGLMLGATGPTETQIKRGLHLQAL 112 Query: 84 --GVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNV 141 G+ L K + +S+ + +T + F+ +++ F +K F E + Sbjct: 113 KPTKPGLLPSLFKGLRETLSRNLELGLTQGSFAFIHKDFDVKETFFNLSKRYFDTECVPM 172 Query: 142 NFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPEN 201 NF + + A +N ++ ETR I L T+L+LV+ + FKG W + F P Sbjct: 173 NFRNASQAKRLMNHYINKETRGKIPKLFDEI---NPETKLILVDYILFKGKWLTPFDPVF 229 Query: 202 TKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTES 261 T+ TF K+ +VPM+ F +++ + + ++LPY G + +ML+ L + Sbjct: 230 TEVDTFHLDKYKTIKVPMMYGAGKF---ASTFDKNFRCHVLKLPYQGNA-TMLVVLMEKM 285 Query: 262 STPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSK 321 L A+ +++T +++W+ M + ++V PKF + ++ E L+ +GI +F Sbjct: 286 GDHL-ALEDYLTTDLVETWLRNMKTRNMEVFFPKFKLDQKYEMHELLRQMGIRRIFSP-F 343 Query: 322 ANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIAR 365 A+ ++++ NL VS +LQ+ IEV E GT+A A + + AR Sbjct: 344 ADLSELSATGRNLQVSRVLQRTVIEVDERGTEAVAGILSEITAR 387 >6F4U-A nrPDB Length = 341 Score = 316 bits (810), Expect = 1e-86, Method: Composition-based stats. Identities = 77/334 (23%), Positives = 146/334 (43%), Gaps = 19/334 (5%) Query: 24 PLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRY 83 L + ++ + + I P NI SP I++ ML LGA ++ Q+ + + Sbjct: 2 SLKIAPANADFAFRFYYLIASETPGKNIFFSPLSISAAYAMLSLGACSHSRSQILEGLGF 61 Query: 84 GVN-----GVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEV 138 + V + + + + + V +A+F+ + + F+ V++ ++ Sbjct: 62 NLTELSESDVHRGFQHLLHTLNLPGHGLETRVGSALFLSHNLKFLAKFLNDTMAVYEAKL 121 Query: 139 RNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQ 198 + NF D IN VK ETR I +L+S D + +VLVN +YFK LW+ F Sbjct: 122 FHTNFYDTVGTIQLINDHVKKETRGKIVDLVSELKKDVL---MVLVNYIYFKALWEKPFI 178 Query: 199 PENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALP 258 T + F + + +VPM+ Q L + + + Y G++ ++ LP Sbjct: 179 SSRTTPKDFYVDENTTVRVPMMLQDQEHHW--YLHDRYLPCSVLRMDYKGDA-TVFFILP 235 Query: 259 TESSTPLSAIIPHISTKTIDSWMSIMVPK----RVQVILPKFTAVAQTDLKEPLKVLGIT 314 + + I ++ + + W +++ + ++++ LPKF+ L + L LG T Sbjct: 236 NQGK--MREIEEVLTPEMLMRWNNLLRKRNFYKKLELHLPKFSISGSYVLDQILPRLGFT 293 Query: 315 DMFDSSKANFAKITTGSENLHVSHILQKAKIEVS 348 D+F S A+ + IT + L S KA ++V Sbjct: 294 DLF-SKWADLSGITK-QQKLEASKSFHKATLDVD 325 >3PZF-A nrPDB Length = 397 Score = 304 bits (778), Expect = 6e-83, Method: Composition-based stats. Identities = 95/383 (24%), Positives = 175/383 (45%), Gaps = 20/383 (5%) Query: 29 ELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLG-------ADGRTKKQLAMVM 81 + + + +I K+ + N+V+SP + +L ++ A TK++L+ V+ Sbjct: 20 QRQNEFDLMFVKEIFKNH-NSNVVLSPFSVKILLTLIYEASDTSFGNAVSNTKRELSSVI 78 Query: 82 RY-GVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRN 140 + ++ K++ ++ + +A FV + E+ + + + Sbjct: 79 QNDNIDHTRSYYKQLLESAQQDNKDYDLNIATNFFVDDFIEVINKYQQIANTHYHAMLEK 138 Query: 141 VNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPE 200 V++ +P +IN WV T + +++PD ++G + + LVN +YFKGLW F Sbjct: 139 VSYSNPTQTAATINNWVSEHTNGRLREIVTPDSLEGAV--ITLVNVIYFKGLWTYPFPEV 196 Query: 201 NTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTE 260 + F GK + Q F +++ DL + LPY G ++M LP Sbjct: 197 ANNVKPFYGTRGKPTNAQYMEQNGQFYYDNSA---DLGAQILRLPYRGNKLAMYFILPNP 253 Query: 261 SSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSS 320 +T ++ ++ I++ ++ + M V V LPKF L EPL+ +GI ++F + Sbjct: 254 DNT-VNQVLDRINSASLHQALWYMEENEVNVTLPKFKFDFSEQLNEPLQQVGIREIFSQN 312 Query: 321 KA--NFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIAR---SSPPWFIVDR 375 + A+ + + VS I QKA I ++E G++A AAT L+ + F +R Sbjct: 313 ASLPLLARGRGARDEVRVSRIFQKAGITINELGSEAYAATEIQLVNKFGGDGVQIFNANR 372 Query: 376 PFLFFIRHNPTGAVLFMGQINKP 398 PF+FFI G +LF G+I P Sbjct: 373 PFIFFIEDETLGTMLFAGKIENP 395 >1IMV-A nrPDB Length = 398 Score = 303 bits (776), Expect = 9e-83, Method: Composition-based stats. Identities = 84/374 (22%), Positives = 173/374 (46%), Gaps = 14/374 (3%) Query: 27 LEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVN 86 L SN G ++ P N+++SP +A+ L L LGAD RT+ + + Y + Sbjct: 34 LAAAVSNFGYDLYRVRSSMSPTTNVLLSPLSVATALSALSLGADERTESIIHRALYYDLI 93 Query: 87 GVGKILKKINKAIVSKKNKDI-VTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFED 145 I + + + + A+ + + I+ FV + + R + + Sbjct: 94 SSPDIHGTYKELLDTVTAPQKNLKSASRIVFEKKLRIKSSFVAPLEKSYGTRPRVLT-GN 152 Query: 146 PASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKR 205 P IN WV+ + + + + ++ D + ++L+ +FKG W ++F T Sbjct: 153 PRLDLQEINNWVQAQMKGKLARS-TKEIPDEI--SILLLGVAHFKGQWVTKFDSRKTSLE 209 Query: 206 TFVAADGKSYQVPMLAQ-LSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTP 264 F + ++ +VPM++ +V R G +DL +LP G S+S++ LP + + Sbjct: 210 DFYLDEERTVRVPMMSDPKAVLRYG---LDSDLSCKIAQLPLTG-SMSIIFFLPLKVTQN 265 Query: 265 LSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANF 324 L+ I ++++ I + + + +PK + ++ + L+ + + +FDS +F Sbjct: 266 LTLIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYEGEVTKSLQEMKLQSLFDSP--DF 323 Query: 325 AKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHN 384 +KIT + + ++ + +A E +EDG + + + P + +++PF+F +R Sbjct: 324 SKITG--KPIKLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLTFPLDYHLNQPFIFVLRDT 381 Query: 385 PTGAVLFMGQINKP 398 TGA+LF+G+I P Sbjct: 382 DTGALLFIGKILDP 395 >3STO-A nrPDB Length = 406 Score = 301 bits (772), Expect = 3e-82, Method: Composition-based stats. Identities = 102/406 (25%), Positives = 182/406 (44%), Gaps = 42/406 (10%) Query: 17 SICSH--FNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGML--QLGADGR 72 +I SH F L + ++ G DN + P GI LG+L GA GR Sbjct: 15 NISSHKAFTHAYLSTVTADFG------------GDNFLTCPLGILFTLGILLGSGGAQGR 62 Query: 73 TKKQLAMVMRY-----------GVNGVGKILKKINKAIVSKKN------KDIVTVANAVF 115 T Q+ MR + + +++N ++ S+K +++V ++ +F Sbjct: 63 TGYQIGKTMRLKSTSSSWNSSEAQQEMKSLYQELNNSLTSEKTFLNEKEENVVRISTGIF 122 Query: 116 VKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLID 175 V+ E+E F + + E++ V+F + SA IN WV ++ +++ + D+ D Sbjct: 123 VEKTYEVERRFNESIANDSEGELKQVDFSNRTSATVDINDWVDQQSNGLLEKFFTDDIPD 182 Query: 176 GVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPN 235 T ++LVN YF+ W+S F+P T+K F + + V M+ Q V + G Sbjct: 183 D--TAMILVNVFYFRDFWQSPFEPHYTRKEDFYISPDRQITVDMMTQEGVMKYGKFE--- 237 Query: 236 DLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPK 295 D + + P + + +I LP E + A K + ++ + V + LPK Sbjct: 238 DEGFEIVSKPLNNTRFTFVIVLPLEKWSLNGATELLNGNKVLSEYVKNLKETTVSLRLPK 297 Query: 296 FTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKAS 355 FT DL LK +G+ D+FD K++ + IT + NL+V+ +Q ++++E G +A+ Sbjct: 298 FTLKNTLDLVPTLKSIGVVDLFDPVKSDLSGITP-NPNLYVNEFIQTNVLKLNESGIEAT 356 Query: 356 AATTAILIARSS---PPWFIVDRPFLFFIRHNPTGAVLFMGQINKP 398 T+ I + S+ F V PF+ FI + ++ P Sbjct: 357 TVTSPIFVPFSAIIPEVDFHVTHPFICFIYDQQLTMPIMAAKVMNP 402 >3LE2-A nrPDB Length = 393 Score = 299 bits (767), Expect = 9e-82, Method: Composition-based stats. Identities = 97/390 (24%), Positives = 176/390 (45%), Gaps = 28/390 (7%) Query: 29 ELGSNTGIQVFNQIVKS-RPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYG-VN 86 L + + + ++ + + N++ SP I VL ++ G+ G TK Q+ +++ + Sbjct: 10 SLQNQVSMNLAKHVITTVSQNSNVIFSPASINVVLSIIAAGSAGATKDQILSFLKFSSTD 69 Query: 87 GVGKILKKINKAIVSKKNKD---IVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNF 143 + +I A+++ + + ++VAN ++ + + F +D ++ +F Sbjct: 70 QLNSFSSEIVSAVLADGSANGGPKLSVANGAWIDKSLSFKPSFKQLLEDSYKAASNQADF 129 Query: 144 EDPA-SACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENT 202 + A +N+W + ET +I +L P+ +T+L+ NA+YFKG W +F T Sbjct: 130 QSKAVEVIAEVNSWAEKETNGLITEVL-PEGSADSMTKLIFANALYFKGTWNEKFDESLT 188 Query: 203 KKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPY----HGESISMLIALP 258 ++ F DG P + + + + LPY SM LP Sbjct: 189 QEGEFHLLDGNKVTAPFMTSKKKQYVSAYD-----GFKVLGLPYLQGQDKRQFSMYFYLP 243 Query: 259 TESSTPLSAIIPHI--STKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDM 316 +++ LS ++ I + +D+ + K + +PKF D LK LG+T Sbjct: 244 -DANNGLSDLLDKIVSTPGFLDNHIPRRQVKVREFKIPKFKFSFGFDASNVLKGLGLTSP 302 Query: 317 FDSSKANFAKITTGSE---NLHVSHILQKAKIEVSEDGTKASAATTAILIAR-----SSP 368 F + ++ E NL VS+I KA IEV+E+GT+A+AA+ ++ R Sbjct: 303 FSGEEG-LTEMVESPEMGKNLCVSNIFHKACIEVNEEGTEAAAASAGVIKLRGLLMEEDE 361 Query: 369 PWFIVDRPFLFFIRHNPTGAVLFMGQINKP 398 F+ D PFL + N TG VLF+GQ+ P Sbjct: 362 IDFVADHPFLLVVTENITGVVLFIGQVVDP 391 >3OZQ-A nrPDB Length = 376 Score = 295 bits (756), Expect = 2e-80, Method: Composition-based stats. Identities = 106/386 (27%), Positives = 192/386 (49%), Gaps = 24/386 (6%) Query: 21 HFNPLSLEE---LGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQL 77 H +L+E ++ V+ +++K+ N ++SP A++L + Q G G T +++ Sbjct: 2 HMEDATLQEFPNAVNSFTPSVYKEVLKTEKA-NFLVSPFSAATLLALAQSGCRGDTAEEI 60 Query: 78 AMVMRY--GVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQ 135 V+ + +K++ + +++ + AN ++VK + F +V+ Sbjct: 61 RQVLHFVGDREKAEGAVKEVLSKLTNEE--YTLHTANKIYVKTNFSVREEFQKIAVEVYG 118 Query: 136 CEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKS 195 + NV+F + A +NAWV+ +T+ I NL+ P++++ LTR+VL+NA+YF W Sbjct: 119 AQSENVDFSEKNDAAKLMNAWVEEQTQHKIQNLVDPEILNN-LTRVVLINALYFNAKWLV 177 Query: 196 RFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLI 255 F P +T+K F + + QV + + + + L +ELP+ G + S+ I Sbjct: 178 PFPPFHTRKSDFHKSAKEVVQVDTMYLDE--QYFNYYECHHLDAKLLELPFKGGA-SLTI 234 Query: 256 ALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITD 315 L + L ++ I + + + V V LPKF + D K+ LK LG+ Sbjct: 235 VLSNQIE-GLVSLESKIKRSFLPH---NLTKQLVNVALPKFKIESTVDFKKVLKKLGVKK 290 Query: 316 MFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARS-----SPPW 370 F +A+ + I +L +S+I+QK+ I+VSE+G +A+AAT +I SP Sbjct: 291 AF-GDEADLSGIAGEKGDLVISNIVQKSFIDVSEEGVEAAAATYIPVILPEMALPDSPKQ 349 Query: 371 FIVDRPFLFFIRHNPTGAVLFMGQIN 396 FIVD PF+F+I G +LF G++ Sbjct: 350 FIVDHPFIFYI--KVKGMILFAGRVT 373 >1JJO-C nrPDB Length = 261 Score = 284 bits (727), Expect = 5e-77, Method: Composition-based stats. Identities = 98/265 (36%), Positives = 162/265 (61%), Gaps = 7/265 (2%) Query: 103 KNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETR 162 +N+ ++ +AN++FV+N + F+ K F EV +V+F + +SIN WV+N T Sbjct: 1 ENQYVMKLANSLFVQNGFHVNEEFLQMLKMYFNAEVNHVDFSQNVAVANSINKWVENYTN 60 Query: 163 DMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQ 222 ++ +L+SP+ DGV T L L+NAVYFKG WKS+F+PENT+ +F D Q+PM+ Q Sbjct: 61 SLLKDLVSPEDFDGV-TNLALINAVYFKGNWKSQFRPENTRTFSFTKDDESEVQIPMMYQ 119 Query: 223 LSVFRCGSTSAPNDLW---YNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDS 279 F G S ++ Y +E+PY G+ ISM++AL + PL+ + P + + I+ Sbjct: 120 QGEFYYGEFSDGSNEAGGIYQVLEIPYEGDEISMMLAL-SRQEVPLATLEPLLKAQLIEE 178 Query: 280 WMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVSHI 339 W + + ++V+V LP+FT + DLK+ LK LG+T++F AN ++ + L +S Sbjct: 179 WANSVKKQKVEVYLPRFTVEQEIDLKDILKALGVTEIF-IKDANLTAMS-DKKELFLSKA 236 Query: 340 LQKAKIEVSEDGTKASAATTAILIA 364 + K+ IEV+E+G++A+AA+ I I+ Sbjct: 237 VHKSCIEVNEEGSEAAAASGMIAIS 261 >2PEF-A nrPDB Length = 373 Score = 283 bits (724), Expect = 1e-76, Method: Composition-based stats. Identities = 97/376 (25%), Positives = 170/376 (45%), Gaps = 28/376 (7%) Query: 32 SNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMR--YGVNGVG 89 ++ I++F + + +N +ISP L M GAD T Q+ + + + Sbjct: 14 ADFSIELFKNSIDDK--ENSLISPLSAMLALAMTANGADNETLAQMEKALGKDISIEDLN 71 Query: 90 KILKKINKAIVSKKNKDIVTVANAV-FVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPAS 148 K L K + +++ K +T+AN++ F +N F+ D ++ ++ F +S Sbjct: 72 KYLYTYMKKLPNEE-KSKLTIANSIWFKENDFMPSKDFLQIIADYYKADIFKAAF--DSS 128 Query: 149 ACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFV 208 IN WVK++T MID +L+ + V + L+NAV F W++ ++ + + F Sbjct: 129 TVSDINNWVKSKTNGMIDKILNKIDPEDV---MYLINAVAFDAEWETVYEKASVHEDIFT 185 Query: 209 AADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAI 268 G +V + +A + PY S + LP E+ + + Sbjct: 186 DVYGNRQKVEFMNSEENLYIEEENAVGFVK------PYAKNHYSFVAILPDENIS----V 235 Query: 269 IPHISTKTIDSWMSIMVPKRVQV---ILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFA 325 +I T T ++ ++ ++ + LPKF + E L+ LG+TD F KA+F+ Sbjct: 236 NEYIKTLTGQKFIDLIKNAKITLVRASLPKFKYEYTIKMNETLESLGMTDAFLPDKADFS 295 Query: 326 KITTGS-ENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWF---IVDRPFLFFI 381 K+ NL++S +L K I V E GTKA A T+ + A P F ++RPF+F I Sbjct: 296 KLGKSDIGNLYISEVLHKTFISVDELGTKAGAVTSVDITAAGIPVNFKTVKLNRPFIFAI 355 Query: 382 RHNPTGAVLFMGQINK 397 N T +F+G + Sbjct: 356 IDNSTNLPIFIGTVLS 371 >1C8O-A nrPDB Length = 300 Score = 272 bits (695), Expect = 2e-73, Method: Composition-based stats. Identities = 89/326 (27%), Positives = 158/326 (48%), Gaps = 26/326 (7%) Query: 36 IQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKI 95 + +F +I S +N+ ISP I+SVL +L GA+G T +QL+ K + Sbjct: 1 MDIFREIASSMKGENVFISPPSISSVLTILYYGANGSTAEQLS--------------KYV 46 Query: 96 NKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINA 155 K K+ N V+ + ++ + F+ + D FQ V+F D + D+IN Sbjct: 47 EKEADKNKDDISFKSMNKVYGRYSAVFKDSFLRKIGDNFQT----VDFTD-SRTVDAINK 101 Query: 156 WVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSY 215 V T I+ LL D T L+ ++AVYFK W F+ E T F + + Sbjct: 102 SVDIFTEGKINPLL--DEPLSPDTSLLAISAVYFKAKWLMPFEKEFTSDYPFYVSPTEMV 159 Query: 216 QVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTK 275 V M++ ++ + ++ IELPY G+ SM++ LP ++ L +I +++ Sbjct: 160 DVSMMSMYGEAFNHASVKESFGNFSIIELPYVGD-TSMVVILP-DNIDGLESIEQNLTDT 217 Query: 276 TIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLH 335 W M + V +PKF +L + L LG+T++F S+ +++ ++ ++ Sbjct: 218 NFKKWSDSMDAMFIDVHIPKFKVTGSYNLVDALVKLGLTEVFGST-GDYSNMSNS--DVS 274 Query: 336 VSHILQKAKIEVSEDGTKASAATTAI 361 V ++ K I+V+E+ T+A+AAT+A+ Sbjct: 275 VDAMIHKTYIDVNEEYTEAAAATSAL 300 >2OAY-A nrPDB Length = 390 Score = 262 bits (669), Expect = 2e-70, Method: Composition-based stats. Identities = 92/397 (23%), Positives = 166/397 (41%), Gaps = 26/397 (6%) Query: 8 FLLASVTLPS-ICSHFNPLSLEELGSNTGIQVFNQIVKSRPHD-NIVISPHGIASVLGML 65 F VTL S + SH L + + +++++ + + N+ SP IAS+L + Sbjct: 12 FCPGPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQV 71 Query: 66 QLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVP 125 LGA TK L ++ Y + +++A+ K + +V + +F I Sbjct: 72 LLGAGENTKTNLESILSYPKD-----FTCVHQALKGFTTKGVTSV-SQIFHSPDLAIRDT 125 Query: 126 FVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVN 185 FV ++ ++ R ++ A+ + IN WV T + I LL D TRLVL+N Sbjct: 126 FVNASRTLYSSSPRVLSNNSDAN-LELINTWVAKNTNNKISRLLDSLPSD---TRLVLLN 181 Query: 186 AVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELP 245 A+Y WK+ F P+ T+ F +VPM+ + L +L Sbjct: 182 AIYLSAKWKTTFDPKKTRMEPFHF-KNSVIKVPMMNSK-KYPVAHFI-DQTLKAKVGQLQ 238 Query: 246 YHGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQ---VILPKFTAVAQT 302 +S++I +P L + +S + M + + Q + LP+ Sbjct: 239 LSHN-LSLVILVPQNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTS- 296 Query: 303 DLKEPLKVLGITDMFD-SSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAI 361 ++ L ++ + FD S N +T +L VS + + +E++E G + AA + Sbjct: 297 --QDMLSIMEKLEFFDFSYDLNLCGLTEDP-DLQVSAMQHQTVLELTETGVE--AAAASA 351 Query: 362 LIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINKP 398 + + F V +PFLF + +FMG++ P Sbjct: 352 ISVARTLLVFEVQQPFLFMLWDQQHKFPVFMGRVYDP 388 >1SNG-A nrPDB Length = 370 Score = 256 bits (653), Expect = 2e-68, Method: Composition-based stats. Identities = 81/381 (21%), Positives = 156/381 (40%), Gaps = 36/381 (9%) Query: 27 LEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVN 86 L + + + ++ ++ P ++ SP+ +A LG+L GA + Sbjct: 10 LRDDHLEFALHLHRRLAEAVPDGEVIWSPYSVACALGVLAAGAR---ATTRTELTTLLGT 66 Query: 87 GVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFE-D 145 +L +++A+ + TV ++V + F D +VR +F + Sbjct: 67 DPAPLLAALDRAVTDSPDLASRTV---LWVSADVPVRSSFRATMHDRPDSDVRTADFRTN 123 Query: 146 PASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKR 205 P ++NA + + TR MI LL + L R +L NA++ K W + F+ T+ Sbjct: 124 PEGVRATVNADIADATRGMIRELLPQGAVTPDL-RAILTNALWAKARWTTPFEAHLTRAG 182 Query: 206 TFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALP---TESS 262 TF G +VP + + + + + L + +++ + LP ++ Sbjct: 183 TFRTPRGP-KRVPFMHRTKTMPYATAR-----GWRMVTLH-AHDELAVDVLLPPGTNAAA 235 Query: 263 TPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKA 322 P + ++ + ++ V++ LP+F L E L G+ +F +S A Sbjct: 236 VPTAPLLTALHRRSAS--------TSVELALPRFELTQPHQLVEVLAEAGVRTLFTAS-A 286 Query: 323 NFAKITTGSENLHVSHILQKAKIEVSED-----GTKASAATTAILIARSSPPWFIVDRPF 377 + + I+T L+V ++ +A++ V E A+ A + F VDRPF Sbjct: 287 DLSGISTV--PLYVDTVIHQARLRVDERGAEGAAATAAMMLLAGAMPPRRTIRFSVDRPF 344 Query: 378 LFFIRHNPTGAVLFMGQINKP 398 +R GA+LF+G I P Sbjct: 345 HIVVRRR--GAILFLGSIADP 363 >6BJ5-B nrPDB Length = 315 Score = 249 bits (637), Expect = 1e-66, Method: Composition-based stats. Identities = 87/328 (26%), Positives = 161/328 (49%), Gaps = 30/328 (9%) Query: 33 NTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKIL 92 + G+ F + DN+V SP+G+ S L +L++ A G TK+++ Sbjct: 17 DIGLWTFRYV--YNESDNVVFSPYGLTSALSVLRIAAGGNTKREI--------------- 59 Query: 93 KKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDS 152 + +++V ++ D +FV + + F F V+ V F + + D Sbjct: 60 -DVPESVV--EDSDAFLALRELFVDASVPLRPEFTAEFSSRFNTSVQRVTF-NSENVKDV 115 Query: 153 INAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADG 212 IN++VK++T + +L D T+++L+++V K W+ F P T + F + Sbjct: 116 INSYVKDKTGGDVPRVL--DASLDRDTKMLLLSSVRMKTSWRHVFDPSFTTDQPFY-SGN 172 Query: 213 KSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHI 272 +Y+V M+ ++ + + + N + Y+ ELPY +ML+ +P + L I+ + Sbjct: 173 VTYKVRMMNKIDTLKTETFTLRN-VGYSVTELPYKRRQTAMLLVVPDD----LGEIVRAL 227 Query: 273 STKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSE 332 + W+ M QV++PKF+ + DL++ L+ LG+ D FD S+A+F + S Sbjct: 228 DLSLVRFWIRNMRKDVCQVVMPKFSVESVLDLRDALQRLGVRDAFDPSRADF-GQASPSN 286 Query: 333 NLHVSHILQKAKIEVSEDGTKASAATTA 360 +L+V+ +LQ +KIE E GT AS+ T Sbjct: 287 DLYVTKVLQTSKIEADERGTTASSDTAI 314 >5C98-A nrPDB Length = 382 Score = 242 bits (619), Expect = 1e-64, Method: Composition-based stats. Identities = 76/372 (20%), Positives = 147/372 (39%), Gaps = 21/372 (5%) Query: 30 LGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQ--LGADGRTKKQLAMVMRYGVNG 87 + ++ F N +SP+ + L M GA + Q+A + V+ Sbjct: 20 ANNKFTLEYFK--ACYDEKCNCAVSPYHVRLALSMFYPLAGAAVQEDFQVAFGLPEDVHA 77 Query: 88 VGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPA 147 + +++ + + ++ + + V V+ ++ F FQ V V+ D Sbjct: 78 AIEQQQRLAQQLHDGQH---LKALSFVLVEETLRLDSEFERLFHRTFQTTVEPVDLTDDI 134 Query: 148 SACDSINAWVKNETRDMIDNLLSPDLID-GVLTRLVLVNAVYFKGLWKSRFQPENTKKRT 206 + ++N++ + ++ D + D+ +L+L + V RF P +T Sbjct: 135 PSALAVNSFYQRANTEIEDFIGEGDVFSLPPCHKLMLFSGVSVLTPLAIRFNPADTALEL 194 Query: 207 FVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGES-ISMLIALPTESSTPL 265 F + + +V + + R N+L +++P+ S +SML+ LP + T L Sbjct: 195 FQFINAPTQRVSTMHTTAFVR---RCLHNELRCKVVDMPFDAASGLSMLVLLPYDG-TEL 250 Query: 266 SAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFA 325 I+ I+ + + + LPKF +TD K+ L LG +F+ + Sbjct: 251 RQIVNSITPAHLAQIDERLQSCWTDLKLPKFFVREKTDPKQTLGKLGYGGVFEIDDLH-- 308 Query: 326 KITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNP 385 + S ++ +Q + VSE G+ A S F +RPF+F IR Sbjct: 309 -VFHDSGRTRLNGFIQHCYLAVSESGSGIPAPPDT-----PSEFEFHANRPFMFLIRRTM 362 Query: 386 TGAVLFMGQINK 397 G VL +G +K Sbjct: 363 DGNVLQVGNFSK 374 >5M3Y-A nrPDB Length = 458 Score = 239 bits (610), Expect = 2e-63, Method: Composition-based stats. Identities = 73/369 (19%), Positives = 152/369 (41%), Gaps = 34/369 (9%) Query: 48 HDNIVISPHGIASVLGMLQLGADGRTKKQLAMVM-----------RYGVNGVGKILKKIN 96 H V+SP + L L LGA T +L ++ R + V L+ + Sbjct: 96 HGATVLSPTAVFGTLASLYLGALDHTADRLQAILGVPWKDKQCTSRLDAHKVLSALQAVQ 155 Query: 97 KAIVSKKNKD-----IVTVANAVFVKNASEIEVPFVTRNKDVFQCEV--RNVNFEDPASA 149 +V++ D +++ VF ++ PFV ++ V R+++F + A Sbjct: 156 GLLVAQGRADSQAQLLLSTVVGVFTAPGLHLKQPFVQGL-ALYTPVVLPRSLDFTELDVA 214 Query: 150 CDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVA 209 + I+ +++ T + L +D L V+F+G K + + + F Sbjct: 215 AEKIDRFMQAVTGWKTGSSLMGASVDST---LAFNTYVHFQG--KMKGFSLLAEPQEFWV 269 Query: 210 ADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAII 269 S VPML+ + F+ S ++ ++P+ ES S+L+ P +S L + Sbjct: 270 DQSTSVSVPMLSGMGTFQHWSDIQDQ---FSVTQVPFT-ESASLLLIQPHYASD-LDKVE 324 Query: 270 PHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITT 329 + +WM + P+ + + +P+ DL++ L + + ++ N K++ Sbjct: 325 GLTFQQNSLNWMKKLSPRTIHLTMPQLVLQGSYDLQDLLAQAELPAIL-HTELNLQKLS- 382 Query: 330 GSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPTGAV 389 ++ + V +L E+ D + + +T + + ++RPFLF + A+ Sbjct: 383 -NDRIRVGEVLNSIFFELEADEREPTEST--QQLNKPEVLEVTLNRPFLFAVYDQSATAL 439 Query: 390 LFMGQINKP 398 F+G++ P Sbjct: 440 HFLGRVANP 448 >1MTP-A nrPDB Length = 323 Score = 230 bits (587), Expect = 8e-61, Method: Composition-based stats. Identities = 66/328 (20%), Positives = 138/328 (42%), Gaps = 29/328 (8%) Query: 27 LEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVN 86 L + + + ++ ++ P ++ SP+ +A LG+L GA T+ + Sbjct: 6 LRDDHLEFALHLHRRLAEAVPDGEVIWSPYSVACALGVLAAGARATTR---TELTTLLGT 62 Query: 87 GVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFE-D 145 +L +++A+ + TV ++V + F D +VR +F + Sbjct: 63 DPAPLLAALDRAVTDSPDLASRTV---LWVSADVPVRSSFRATMHDRPDSDVRTADFRTN 119 Query: 146 PASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKR 205 P ++NA + + TR MI LL + L R +L NA++ K W + F+ T++ Sbjct: 120 PEGVRATVNADIADATRGMIRELLPQGAVTPDL-RAILTNALWAKARWTTPFEAHLTREG 178 Query: 206 TFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALP---TESS 262 TF G +VP + + + + + L + +++ + LP ++ Sbjct: 179 TFRTPRGP-KRVPFMHRTKTMPYATAR-----GWRMVTLH-AHDELAVDVLLPPGTNAAA 231 Query: 263 TPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKA 322 P + ++ + ++ V++ LP+F L E L G+ +F +S A Sbjct: 232 VPTAPLLTALHRRSAS--------TSVELALPRFELTQPHQLVEVLAEAGVRTLFTAS-A 282 Query: 323 NFAKITTGSENLHVSHILQKAKIEVSED 350 + + I+T L+V ++ +A++ V E Sbjct: 283 DLSGISTV--PLYVDTVIHQARLRVDER 308 >2WXZ-C nrPDB Length = 453 Score = 227 bits (580), Expect = 5e-60, Method: Composition-based stats. Identities = 79/387 (20%), Positives = 158/387 (40%), Gaps = 34/387 (8%) Query: 32 SNT-GIQVFNQIVKSRP-HDNIVISPHGIASVLGMLQLGADGRTKKQLAMVM-------- 81 +N G +++ + ++R V+SP + L LG+ T QL +++ Sbjct: 77 ANFMGFRMYKMLSEARGVASGAVLSPPALFGTLVSFYLGSLDPTASQLQVLLGVPVKEGD 136 Query: 82 ---RYGVNGVGKILKKINKAIVSKKNKD-----IVTVANAVFVKNASEIEVPFVTRNKDV 133 R + V L+ + +V++ + + +F ++ PFV Sbjct: 137 CTSRLDGHKVLTALQAVQGLLVTQGGSSSQTPLLQSTVVGLFTAPGLRLKQPFVESLGPF 196 Query: 134 FQCE-VRNVNFE-DPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKG 191 R+++ DP A IN +V+ T ++ L D L V+F+G Sbjct: 197 TPAIFPRSLDLSTDPVLAAQKINRFVQAVTGWKMNLPLEGVSTDST---LFFNTYVHFQG 253 Query: 192 LWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESI 251 K R + T F + S VPML+ F+ S + N ++ +P GES+ Sbjct: 254 --KMRGFSQLTGLHEFWVDNSTSVSVPMLSGTGNFQHWSDAQNN---FSVTRVPL-GESV 307 Query: 252 SMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVL 311 ++L+ P + ++ L + + +W+ P+ +++ LP+ +L++ L Sbjct: 308 TLLLIQP-QCASDLDRVEVLVFQHDFLTWIKNPPPRAIRLTLPQLEIRGSYNLQDLLAQA 366 Query: 312 GITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWF 371 ++ + ++AN K+ G N V +L +E+ + G + +A Sbjct: 367 KLSTLL-GAEANLGKM--GDTNPRVGEVLNSILLEL-QAGEEEQPTESAQQPGSPEVLDV 422 Query: 372 IVDRPFLFFIRHNPTGAVLFMGQINKP 398 + PFLF I +GA+ F+G+++ P Sbjct: 423 TLSSPFLFAIYERDSGALHFLGRVDNP 449 >1M93-B nrPDB Length = 245 Score = 224 bits (570), Expect = 7e-59, Method: Composition-based stats. Identities = 68/255 (26%), Positives = 125/255 (49%), Gaps = 12/255 (4%) Query: 107 IVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMID 166 N V+ + ++ + F+ + D FQ V+F D + D+IN V T I+ Sbjct: 3 SFKSMNKVYGRYSAVFKDSFLRKIGDNFQT----VDFTD-SRTVDAINKSVDIFTEGKIN 57 Query: 167 NLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVF 226 LL D T L+ ++AVYFK W F+ E T F + + V M++ Sbjct: 58 PLL--DEPLSPDTSLLAISAVYFKAKWLMPFEKEFTSDYPFYVSPTEMVDVSMMSMYGEA 115 Query: 227 RCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVP 286 ++ + ++ IELPY G+ SM++ LP ++ L +I +++ W M Sbjct: 116 FNHASVKESFGNFSIIELPYVGD-TSMVVILP-DNIDGLESIEQNLTDTNFKKWSDSMDA 173 Query: 287 KRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKIE 346 + V +PKF +L + L LG+T++F S+ +++ ++ ++ V ++ K I+ Sbjct: 174 MFIDVHIPKFKVTGSYNLVDALVKLGLTEVFGST-GDYSNMSNS--DVSVDAMIHKTYID 230 Query: 347 VSEDGTKASAATTAI 361 V+E+ T+A+AAT+A+ Sbjct: 231 VNEEYTEAAAATSAL 245 >2WXX-A nrPDB Length = 453 Score = 214 bits (545), Expect = 6e-56, Method: Composition-based stats. Identities = 73/388 (18%), Positives = 152/388 (39%), Gaps = 36/388 (9%) Query: 32 SNT-GIQVFNQIVKSRPHDN-IVISPHGIASVLGMLQLGADGRTKKQLAMVM-------- 81 +N G +++ + ++ + ++SP + L LG+ T QL ++ Sbjct: 77 TNFVGFRMYKMLNEAGSGASGAILSPPALFGTLVSFYLGSLDPTASQLQTLLDVPVKEGD 136 Query: 82 ---RYGVNGVGKILKKINKAIVSKKNKD-----IVTVANAVFVKNASEIEVPFVTRNKDV 133 R + V L+ + +V++ + ++ +F ++ FV + Sbjct: 137 CTSRLDGHKVLAALRAVQGLLVTQGGSSSQTPLLQSIVVGLFTAPGFRLKHSFVQSL-AL 195 Query: 134 FQCEVRN--VNFE-DPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFK 190 F + ++ DP A + IN ++K T ++ L D L+ V+F+ Sbjct: 196 FTPALFPRSLDLSTDPVLATEKINRFIKAVTGWKMNLPLEGVSTDST---LLFNTYVHFQ 252 Query: 191 GLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGES 250 G R + F + S VPM++ F+ S + N ++ +P GE Sbjct: 253 G--TMRGFSQLPGVHEFWVDNSISVSVPMISGTGNFQHWSDAQNN---FSVTCVPL-GER 306 Query: 251 ISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKV 310 ++L+ P + L + I + +W+ P+ +++ LP+ +L++ L Sbjct: 307 ATLLLIQPH-CISDLDRVEALIFQNDLLTWIENPPPRAIRLTLPQLEIRGSYNLQDLLAE 365 Query: 311 LGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPW 370 + + ++AN I G N V +L +E+ + G + T+ Sbjct: 366 DKLPTLL-GAEANLNNI--GDTNPRVGEVLNSILLEL-KAGEEEQPTTSVQQPGSPEALD 421 Query: 371 FIVDRPFLFFIRHNPTGAVLFMGQINKP 398 + PFLF I +G + F+G++N P Sbjct: 422 VTLSSPFLFAIYEQDSGTLHFLGRVNNP 449 >4R9I-A nrPDB Length = 378 Score = 85.0 bits (209), Expect = 6e-17, Method: Composition-based stats. Identities = 62/360 (17%), Positives = 133/360 (36%), Gaps = 21/360 (5%) Query: 44 KSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRY-GVNGVGKILKKINKAIVSK 102 + P N + + +L L L + T +L + + V + + +N + +K Sbjct: 34 QYEPERNQFSTAFPLLFMLSELSLNSKEDTTAELYKNLNLRSEDEVVNVNQAVNTNLNTK 93 Query: 103 KNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETR 162 T+ + S F+ VF V+N+++ + A A +I +++++ Sbjct: 94 NEVYQSTLILNAYTDIDSPFSETFIQNFAKVFNGTVKNIDYSNDAVA--TIRDSLQSDSG 151 Query: 163 DMIDNLLSPDLIDGVLTRLVLVNA--VYFK-GLWKSRFQPENTKKRTFVAADGKSYQVPM 219 + I+ L I+ T ++L +YF G ++P +F A DG Sbjct: 152 NDIEIALKDGDINKD-TGIILTAYTNIYFPWGEASDSYRPYKQIDISFTALDGTQSNKQA 210 Query: 220 LAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDS 279 + +L + +L +++ A T+ Sbjct: 211 WYSEGAGKYAEIE---NLGIKVFQFSLKPGLTVVLGTSLNDNNDLSGAFNKLRDPATLAY 267 Query: 280 WMSIMVPKRVQVILP-KFTAVAQTDLKEPLKVLGI-TDMFDSSKANFAKITTGSENLHVS 337 ++ K +++ +P + T D +K G+ T++F+ + F + ++S Sbjct: 268 ILTQTESKYLKLAVPIELTMRDSRDYIPEVKRAGLLTELFEKNFDGFDTVYDNKSG-YIS 326 Query: 338 HILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINK 397 ++L ++E E T+ AA+ + P FI D+P+ F + F+G I Sbjct: 327 YMLSHTRLEF-EQPTEEQAASVV------AEPDFIFDKPYFFLVLDQF-NTPAFIGLITN 378 >4P2L-A nrPDB Length = 506 Score = 34.2 bits (77), Expect = 0.11, Method: Composition-based stats. Identities = 17/84 (20%), Positives = 26/84 (30%), Gaps = 16/84 (19%) Query: 118 NASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGV 177 FV F + NF SIN W++ + + I +D Sbjct: 285 QRLVALKKFVAVLAKYFPGQPLVQNF------LHSINDWLQKQQKKKIPYSYFKAALDSH 338 Query: 178 LTRLVL---VNAV-------YFKG 191 VL VN + +F+G Sbjct: 339 KENAVLAEKVNWIGCQGSEPHFRG 362 >3T59-A nrPDB Length = 519 Score = 33.4 bits (75), Expect = 0.19, Method: Composition-based stats. Identities = 24/132 (18%), Positives = 40/132 (30%), Gaps = 24/132 (18%) Query: 73 TKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFV---KNASEIEVPFVTR 129 T ++A + + + + A+ I+ V F FV Sbjct: 254 TADKIAPTVWKFADRSKIYMADLESALH-----YILRVEVGKFSVLEGQRLVALKKFVAV 308 Query: 130 NKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVL---VNA 186 F + NF SIN W++ + + I +D VL VN Sbjct: 309 LAKYFPGQPLVQNF------LHSINDWLQKQQKKRIPYSFFKAALDSRKEDAVLTEKVNW 362 Query: 187 V-------YFKG 191 V +F+G Sbjct: 363 VGCQGSEPHFRG 374 >3LLI-A nrPDB Length = 261 Score = 32.6 bits (73), Expect = 0.31, Method: Composition-based stats. Identities = 18/84 (21%), Positives = 26/84 (30%), Gaps = 16/84 (19%) Query: 118 NASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGV 177 FV F NF S+N W+K + R+ I +D Sbjct: 40 QRLVALKKFVAVLAKYFPGRPLVQNF------LHSVNEWLKRQKRNKIPYSFFKTALDDR 93 Query: 178 LTRLVL---VNAV-------YFKG 191 VL VN + +F+G Sbjct: 94 KEGAVLAKKVNWIGCQGSEPHFRG 117 >3N2S-A nrPDB Length = 249 Score = 31.5 bits (70), Expect = 0.71, Method: Composition-based stats. Identities = 24/167 (14%), Positives = 54/167 (32%), Gaps = 20/167 (11%) Query: 27 LEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVN 86 + EL NT + + + I + N+ S + LG+ +G ++ V++ + Sbjct: 97 ISELLENTEMFMVSLIDAALAAQNM--SIAAESMGLGICYIGGIRNELDKVTEVLQ-TPD 153 Query: 87 GVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDP 146 V + + K AV+ +N + + + Sbjct: 154 HVLPLFGLAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYD----------- 202 Query: 147 ASACDSINAWVKNETRDMIDNLLSPDLID--GVLTRLVLVNAVYFKG 191 +I+ + + T + S +++ R L + V KG Sbjct: 203 ----KTISDYYRERTNGKREETWSDQILNFMKQKPRTYLNDYVKEKG 245 >1XZW-A nrPDB Length = 426 Score = 31.1 bits (69), Expect = 0.79, Method: Composition-based stats. Identities = 6/58 (10%), Positives = 21/58 (36%), Gaps = 1/58 (1%) Query: 192 LWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGE 249 W + + K + + + KS + + + ++ + ++ +L Y + Sbjct: 43 SWTTPYDKAGANKVFYWSENSKSQK-RAMGTVVTYKYYNYTSAFIHHCTIKDLEYDTK 99 >5TUM-A nrPDB Length = 410 Score = 31.1 bits (69), Expect = 0.95, Method: Composition-based stats. Identities = 25/144 (17%), Positives = 47/144 (32%), Gaps = 29/144 (20%) Query: 64 MLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIE 123 ++ LGA T + + + + N +VS + + +A A F+ + + Sbjct: 195 LIHLGAYLSTFT-IPNYLGLSHIDLE---CEANNKLVSINSDNNPEIARAGFMFRSQHLL 250 Query: 124 VP---------FVTRNKDVFQCEVRNV--------NFEDPASACDSINAWVKNETRDMID 166 F+ F E +N+ +F A +N+W T+ I Sbjct: 251 NDIRDEQEQKQFLRDTFRDFGWETQNILNRMPESNDFYFDAITQVKMNSW----TKGRIA 306 Query: 167 NLLS----PDLIDGVLTRLVLVNA 186 + P + G L V A Sbjct: 307 LVGDAGYCPSPLSGQGNNLAFVGA 330 >3ES8-A nrPDB Length = 391 Score = 29.9 bits (66), Expect = 1.8, Method: Composition-based stats. Identities = 16/74 (21%), Positives = 32/74 (43%), Gaps = 14/74 (18%) Query: 113 AVFVKNASEIEVPFVTRNKDVFQCEVR--NVNFE---DPASACDSINAWVKNETR----- 162 ++V + + F++R K+ F VR + +F + A +I K T+ Sbjct: 162 RLYVGKNLDADEEFLSRVKEEFGSRVRIKSYDFSHLLNWKDAHRAI----KRLTKYDLGL 217 Query: 163 DMIDNLLSPDLIDG 176 +MI++ + DG Sbjct: 218 EMIESPAPRNDFDG 231 >3JD5-e nrPDB Length = 415 Score = 29.9 bits (66), Expect = 2.0, Method: Composition-based stats. Identities = 16/81 (19%), Positives = 35/81 (43%), Gaps = 1/81 (1%) Query: 65 LQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKN-KDIVTVANAVFVKNASEIE 123 L+ GA + L ++YG+ + + K+N KD ++V + ++ A E+ Sbjct: 117 LKYGAQDKALYTLVNKVQYGIFPDNYTFNLLMDHFIKKENYKDALSVVFEIMMQEAFEVP 176 Query: 124 VPFVTRNKDVFQCEVRNVNFE 144 + ++QC + +F Sbjct: 177 STQLLSLYVLYQCLAKKTDFS 197 >6CW2-D nrPDB Length = 251 Score = 29.5 bits (65), Expect = 2.4, Method: Composition-based stats. Identities = 7/51 (13%), Positives = 14/51 (27%) Query: 206 TFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIA 256 F + + + M+ + P L Y +SM + Sbjct: 35 EFRVVNNDNTKENMMVLTGLKNIFQKQLPKMPKEYIARLVYDRSHLSMAVI 85 >4WY5-A nrPDB Length = 332 Score = 29.5 bits (65), Expect = 2.5, Method: Composition-based stats. Identities = 12/64 (18%), Positives = 27/64 (42%), Gaps = 1/64 (1%) Query: 73 TKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKD 132 T+ Q+ V+ + ++G G + I ++ + VFV + E F T ++ Sbjct: 75 TEDQILPVLIF-LHGGGFVFGSKYTHIKPVRDLTVKANVVTVFVDYSLSPEAKFPTAIEE 133 Query: 133 VFQC 136 ++ Sbjct: 134 IYAA 137 >2QGH-A nrPDB Length = 425 Score = 29.5 bits (65), Expect = 2.7, Method: Composition-based stats. Identities = 19/121 (15%), Positives = 42/121 (34%), Gaps = 12/121 (9%) Query: 54 SPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANA 113 S I S+L L+ GAD + ++ ++ G+ + + K+ + + N Sbjct: 69 SNLSILSLLAHLESGADCVSIGEIQRALKAGIKPYRIVFSGVGKSAFEIEQALKL---NI 125 Query: 114 VFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDL 173 +F+ F+ + +++ A IN + +T I L + Sbjct: 126 LFLN-----VESFMEL--KTIETIAQSL--GIKARISIRINPNIDAKTHPYISTGLKENK 176 Query: 174 I 174 Sbjct: 177 F 177 >5W76-A nrPDB Length = 385 Score = 28.8 bits (63), Expect = 3.9, Method: Composition-based stats. Identities = 10/42 (23%), Positives = 18/42 (42%) Query: 345 IEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPT 386 +E E+G +A + + P +D+PFL I + Sbjct: 171 LEGDEEGEEAIMKLMDAVDSYIPEPERAIDKPFLMPIEDVFS 212 >1F2V-A nrPDB Length = 219 Score = 28.4 bits (62), Expect = 5.1, Method: Composition-based stats. Identities = 8/42 (19%), Positives = 17/42 (40%) Query: 28 EELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGA 69 E ++ +++ + V SP ++S L+ GA Sbjct: 40 SEEEADLAVRMVHACGSVEATRQFVFSPDFVSSARAALKAGA 81 >5BRA-A nrPDB Length = 350 Score = 28.4 bits (62), Expect = 5.5, Method: Composition-based stats. Identities = 8/42 (19%), Positives = 15/42 (35%) Query: 52 VISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILK 93 P + ML + A + Q+ + G+ G +L Sbjct: 282 FWDPAVAGYAMNMLAVAALEKKNDQIKAGLNLGLPGYESLLA 323 >3W6J-B nrPDB Length = 184 Score = 28.4 bits (62), Expect = 5.8, Method: Composition-based stats. Identities = 17/126 (13%), Positives = 44/126 (34%), Gaps = 5/126 (3%) Query: 57 GIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFV 116 I L + G +G + Q+A V+ +++++ + ++ + VF+ Sbjct: 12 AIVEAL-LFAAGDEGLSLSQIAAVLEVSELEAKAVIEELQQDCRREERGIQLVELGGVFL 70 Query: 117 KNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDG 176 + P++ + + A +I A+ + TR I+ + Sbjct: 71 LATKKEHAPYLKKLVEAPGASP----LSQAALETLAIIAYRQPITRAEIEEIRGVKSDKP 126 Query: 177 VLTRLV 182 + T + Sbjct: 127 LQTLMA 132 >4ZR0-A nrPDB Length = 392 Score = 28.0 bits (61), Expect = 7.2, Method: Composition-based stats. Identities = 13/72 (18%), Positives = 27/72 (37%), Gaps = 14/72 (19%) Query: 341 QKAKIEVSEDGTKASAATTAILIARSSPPWF--------------IVDRPFLFFIRHNPT 386 K ++++S DGT+ + T + ++RP L I + Sbjct: 104 HKVEVQLSADGTEFDSTTFVKELPAEEKLSIATDYSNDYKKHKFLDLNRPLLMQILRSDF 163 Query: 387 GAVLFMGQINKP 398 ++ QI++P Sbjct: 164 KKDFYVDQIHRP 175 >3BNF-A nrPDB Length = 485 Score = 28.0 bits (61), Expect = 7.4, Method: Composition-based stats. Identities = 19/123 (15%), Positives = 31/123 (25%), Gaps = 21/123 (17%) Query: 188 YFKGLWKSRFQPENTKKRTFVAADGKSY----QVPML------AQLSVFRCGSTSAPNDL 237 YF G W + D KS +VP L A F + L Sbjct: 128 YFTGKWAKYGDEIVNTIGCYNCHDDKSAELKSKVPYLDRGLSAAGFKTFAESTHQEKRSL 187 Query: 238 WYNFIELPY----------HG-ESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVP 286 + Y G + +M++ LP + + W + Sbjct: 188 VCAQCHVEYYFKKTEWKDDKGVDKTAMVVTLPWSKGISTEQMEAYYDEINFADWTHGISK 247 Query: 287 KRV 289 + Sbjct: 248 TPM 250 >4ZR1-A nrPDB Length = 298 Score = 28.0 bits (61), Expect = 8.6, Method: Composition-based stats. Identities = 13/72 (18%), Positives = 27/72 (37%), Gaps = 14/72 (19%) Query: 341 QKAKIEVSEDGTKASAATTAILIARSSPPWF--------------IVDRPFLFFIRHNPT 386 K ++++S DGT+ + T + ++RP L I + Sbjct: 10 HKVEVQLSADGTEFDSTTFVKELPAEEKLSIATDYSNDYKKHKFLDLNRPLLMQILRSDF 69 Query: 387 GAVLFMGQINKP 398 ++ QI++P Sbjct: 70 KKDFYVDQIHRP 81 >1KEA-A nrPDB Length = 221 Score = 27.6 bits (60), Expect = 8.9, Method: Composition-based stats. Identities = 20/84 (23%), Positives = 34/84 (40%), Gaps = 3/84 (3%) Query: 67 LGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAV---FVKNASEIE 123 +G + +QL + R +N G + + KAI+ T A + F K A+ ++ Sbjct: 85 IGLSNQRAEQLKELARVVINDYGGRVPRNRKAILDLPGVGKYTCAAVMCLAFGKKAAMVD 144 Query: 124 VPFVTRNKDVFQCEVRNVNFEDPA 147 FV F N+N+ A Sbjct: 145 ANFVRVINRYFGGSYENLNYNHKA 168 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.310 0.145 0.421 Lambda K H 0.267 0.0447 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,680,463 Number of Sequences: 36641 Number of extensions: 608455 Number of successful extensions: 2491 Number of sequences better than 10.0: 84 Number of HSP's better than 10.0 without gapping: 126 Number of HSP's successfully gapped in prelim test: 35 Number of HSP's that attempted gapping in prelim test: 1799 Number of HSP's gapped (non-prelim): 165 length of query: 398 length of database: 10,336,785 effective HSP length: 99 effective length of query: 299 effective length of database: 6,709,326 effective search space: 2006088474 effective search space used: 2006088474 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 60 (27.6 bits)