BLASTP 2.2.23 [Feb-03-2010] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= P07003 (572 letters) Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta 36,641 sequences; 10,336,785 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value 3EYA-A nrPDB 1138 0.0 1V5E-A nrPDB 258 5e-69 2EZ4-A nrPDB 258 6e-69 5WJ1-A nrPDB 218 6e-57 6DEO-A nrPDB 179 4e-45 1T9B-A nrPDB 179 4e-45 5D6R-B nrPDB 165 4e-41 4RJK-A nrPDB 155 4e-38 2PAN-A nrPDB 152 4e-37 5AHK-A nrPDB 125 4e-29 2PGN-A nrPDB 108 5e-24 4QQ8-A nrPDB 102 3e-22 2Q28-A nrPDB 101 7e-22 6A50-A nrPDB 87 3e-17 5NPU-A nrPDB 86 4e-17 2VBF-A nrPDB 82 9e-16 1UPC-A nrPDB 80 3e-15 4ZP1-A nrPDB 77 2e-14 2JI6-A nrPDB 76 3e-14 2Q5O-A nrPDB 72 7e-13 4Q9D-A nrPDB 71 2e-12 1OVM-A nrPDB 67 2e-11 5EUJ-A nrPDB 64 2e-10 4K9Q-A nrPDB 60 3e-09 6EFG-A nrPDB 56 5e-08 2VBI-A nrPDB 52 5e-07 4COK-A nrPDB 49 7e-06 1QPB-A nrPDB 48 1e-05 5B47-B nrPDB 35 0.12 2VHY-A nrPDB 30 2.3 4AAJ-A nrPDB 30 3.2 3EU9-A nrPDB 29 4.3 3LCG-A nrPDB 29 5.3 6HMF-A nrPDB 29 6.2 6HMS-A nrPDB 29 6.6 2X7J-A nrPDB 29 7.2 4XFM-A nrPDB 28 9.4 >3EYA-A nrPDB Length = 549 Score = 1138 bits (2943), Expect = 0.0, Method: Compositional matrix adjust. Identities = 549/549 (100%), Positives = 549/549 (100%) Query: 1 MKQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAE 60 MKQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAE Sbjct: 1 MKQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAE 60 Query: 61 AQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQEL 120 AQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQEL Sbjct: 61 AQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQEL 120 Query: 121 FRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDVALKPAPEGATMHWYHAP 180 FRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDVALKPAPEGATMHWYHAP Sbjct: 121 FRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDVALKPAPEGATMHWYHAP 180 Query: 181 QPVVTPEEEELRKLAQLLRYSSNIALMCGSGCAGAHKELVEFAGKIKAPIVHALRGKEHV 240 QPVVTPEEEELRKLAQLLRYSSNIALMCGSGCAGAHKELVEFAGKIKAPIVHALRGKEHV Sbjct: 181 QPVVTPEEEELRKLAQLLRYSSNIALMCGSGCAGAHKELVEFAGKIKAPIVHALRGKEHV 240 Query: 241 EYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPYRAFYPTDAKIIQIDINPASIGA 300 EYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPYRAFYPTDAKIIQIDINPASIGA Sbjct: 241 EYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPYRAFYPTDAKIIQIDINPASIGA 300 Query: 301 HSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGLDDLAKPSEKAIHPQ 360 HSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGLDDLAKPSEKAIHPQ Sbjct: 301 HSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGLDDLAKPSEKAIHPQ 360 Query: 361 YLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAMPQALGAQA 420 YLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAMPQALGAQA Sbjct: 361 YLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAMPQALGAQA 420 Query: 421 TEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAMEMKAGGYLTDGT 480 TEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAMEMKAGGYLTDGT Sbjct: 421 TEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAMEMKAGGYLTDGT 480 Query: 481 ELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDVVVAKEELAIPPQIKL 540 ELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDVVVAKEELAIPPQIKL Sbjct: 481 ELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDVVVAKEELAIPPQIKL 540 Query: 541 EQAKGFSLY 549 EQAKGFSLY Sbjct: 541 EQAKGFSLY 549 >1V5E-A nrPDB Length = 590 Score = 258 bits (659), Expect = 5e-69, Method: Compositional matrix adjust. Identities = 160/523 (30%), Positives = 263/523 (50%), Gaps = 14/523 (2%) Query: 2 KQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSL-NRMGTIEWMSTRHEEVAAFAAGAE 60 K + + K LES G I+G+ +L+ L D++ ++++ +HEEV A AA + Sbjct: 3 KINIGLAVMKILESWGADTIYGIPSGTLSSLMDAMGEEENNVKFLQVKHEEVGAMAAVMQ 62 Query: 61 AQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQEL 120 ++ G L V GS GPG HLINGL+D +++PV+AI P E+ FQE + + Sbjct: 63 SKFGGNLGVTVGSGGPGASHLINGLYDAAMDNIPVVAILGSRPQRELNMDAFQELNQNPM 122 Query: 121 FRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDVALKPAPEGATMHWYHAP 180 + + Y V+ EQ+P+++ A R A+ RGV+V+ +PGD A E WY + Sbjct: 123 YDHIAVYNRRVAYAEQLPKLVDEAARMAIAKRGVAVLEVPGDFA---KVEIDNDQWYSSA 179 Query: 181 QPV-----VTPEEEELRKLAQLLRYSSNIALMCGSGCAGAHKELVEFAGKIKAPIVHALR 235 + + P +++ +LL S + G G G + E A KIKAP++ + Sbjct: 180 NSLRKYAPIAPAAQDIDAAVELLNNSKRPVIYAGIGTMGHGPAVQELARKIKAPVITTGK 239 Query: 236 GKEHVEYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPYR----AFYPTDAKIIQI 291 E E+D G T +G+ T++ ADT++ G+ FP+ F D IQI Sbjct: 240 NFETFEWDFEALTGSTYRVGWKPANETILEADTVLFAGSNFPFSEVEGTFRNVD-NFIQI 298 Query: 292 DINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGLDDLAK 351 DI+PA +G D+A++GD + +L V+ + + L++ + R+ ++ L Sbjct: 299 DIDPAMLGKRHHADVAILGDAALAIDEILNKVDAVEESAWWTANLKNIANWREYINMLET 358 Query: 352 PSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANA 411 E + + I++ A +DAI++ DVG T + R+L M K S +M A Sbjct: 359 KEEGDLQFYQVYNAINNHADEDAIYSIDVGNSTQTSIRHLHMTPKNMWRTSPLFATMGIA 418 Query: 412 MPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAMEMK 471 +P LGA+ T P+RQV + GDG FSM D ++ V+ +PV VVF+N+ F+ + + Sbjct: 419 IPGGLGAKNTYPDRQVWNIIGDGAFSMTYPDVVTNVRYNMPVINVVFSNTEYAFIKNKYE 478 Query: 472 AGGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRA 514 G + D ++A+IAEA G G V + ++D + A Sbjct: 479 DTNKNLFGVDFTDVDYAKIAEAQGAKGFTVSRIEDMDRVMAEA 521 >2EZ4-A nrPDB Length = 603 Score = 258 bits (658), Expect = 6e-69, Method: Compositional matrix adjust. Identities = 172/563 (30%), Positives = 284/563 (50%), Gaps = 25/563 (4%) Query: 1 MKQT------VAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLN-RMGTIEWMSTRHEEVA 53 MKQT A + K LE+ GV ++G+ G S+N + D+L+ I ++ RHEEV Sbjct: 3 MKQTKQTNILAGAAVIKVLEAWGVDHLYGIPGGSINSIMDALSAERDRIHYIQVRHEEVG 62 Query: 54 AFAAGAEAQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQ 113 A AA A+A+L+G++ VC GS GPG HL+NGL+D +HVPVLA+ ++ + FQ Sbjct: 63 AMAAAADAKLTGKIGVCFGSAGPGGTHLMNGLYDAREDHVPVLALIGQFGTTGMNMDTFQ 122 Query: 114 ETHPQELFRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDVALKPAPEGAT 173 E + ++ + + Y + +P V+ A+R+A ++GV+VV +P D+ + P Sbjct: 123 EMNENPIYADVADYNVTAVNAATLPHVIDEAIRRAYAHQGVAVVQIPVDLPWQQIP---A 179 Query: 174 MHWYHAPQPVVTP-----EEEELRKLAQLLRYSSNIALMCGSGCAGAHKELVEFAGKIKA 228 WY + TP + + + +L Q L + + G G A KEL + + +K Sbjct: 180 EDWYASANSYQTPLLPEPDVQAVTRLTQTLLAAERPLIYYGIGARKAGKELEQLSKTLKI 239 Query: 229 PIVHALRGKEHVEYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPY----RAFYPT 284 P++ K V P +G + + AD ++ +G +P+ +AF T Sbjct: 240 PLMSTYPAKGIVADRYPAYLGSANRVAQKPANEALAQADVVLFVGNNYPFAEVSKAFKNT 299 Query: 285 DAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARK 344 +QIDI+PA +G K D+A++ D + TL A+L V E+ + L + ++ R Sbjct: 300 -RYFLQIDIDPAKLGKRHKTDIAVLADAQKTLAAILAQVSERESTPWWQANLANVKNWRA 358 Query: 345 GLDDLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFN 404 L L E + + + ++ A DAI++ DVG + A R+LK+ R + S Sbjct: 359 YLASLEDKQEGPLQAYQVLRAVNKIAEPDAIYSIDVGDINLNANRHLKLTPSNRHITSNL 418 Query: 405 HGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLG 464 +M +P A+ A+ PERQV + GDGG SM M D + VQ LPV VVF N G Sbjct: 419 FATMGVGIPGAIAAKLNYPERQVFNLAGDGGASMTMQDLATQVQYHLPVINVVFTNCQYG 478 Query: 465 FVAMEMKAGGYLTD--GTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSI--DGP 520 ++ E + D G E +D +F++IA+ + RV K ++ + ++A +I P Sbjct: 479 WIKDEQEDTNQ-NDFIGVEFNDIDFSKIADGVHMQAFRVNKIEQLPDVFEQAKAIAQHEP 537 Query: 521 VLVDVVVAKEELAIPPQIKLEQA 543 VL+D V+ + +++L+ A Sbjct: 538 VLIDAVITGDRPLPAEKLRLDSA 560 >5WJ1-A nrPDB Length = 590 Score = 218 bits (555), Expect = 6e-57, Method: Compositional matrix adjust. Identities = 160/557 (28%), Positives = 263/557 (47%), Gaps = 34/557 (6%) Query: 6 AAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQLSG 65 A + + LE GV+ ++ G + + +L R +I + RHE+ FAA A+ SG Sbjct: 15 ADILVEALERQGVETVFAYPGGASMEIHQALTRSSSIRNVLPRHEQGGVFAAEGYARSSG 74 Query: 66 ELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFRECS 125 + +C + GPG +L++GL D + VP++AI +P IG+ FQET E+ R + Sbjct: 75 KPGICIATSGPGATNLVSGLADALLDSVPLVAITGQVPRRMIGTDAFQETPIVEVTRSIT 134 Query: 126 HYCELVSSPEQIPQVLAIAMRKAVLNR-GVSVVVLPGDVALKPAPEGATMHWYHA----- 179 + LV E IP+++ A A R G +V +P D+ + A +W A Sbjct: 135 KHNYLVMDVEDIPRIIEEAFFLATSGRPGPVLVDVPKDI----QQQLAIPNWEQAMRLPG 190 Query: 180 -----PQPVVTPEEEELRKLAQLLRYSSNIALMCGSGCAGAHKELVEFAGKIKAPIVHAL 234 P+P PE+ L ++ +L+ S L G GC + EL F P+ L Sbjct: 191 YMSRMPKP---PEDSHLEQIVRLISESKKPVLYVGGGCLNSSDELGRFVELTGIPVASTL 247 Query: 235 RGKEHVEYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPYRAF-----YPTDAKII 289 G D+ + M G+ G + + ++D L+ G +F R + + AKI+ Sbjct: 248 MGLGSYPCDDELSLHMLGMHGTVYANYAVEHSDLLLAFGVRFDDRVTGKLEAFASRAKIV 307 Query: 290 QIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKAL-EDYRDARKGLDD 348 IDI+ A IG + +++ GD+K L+ + ++E +A+ LD + + + +K Sbjct: 308 HIDIDSAEIGKNKTPHVSVCGDVKLALQGMNKVLENRAEELKLDFGVWRNELNVQKQKFP 367 Query: 349 LA-KPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGS 407 L+ K +AI PQY + + AI + VG +WAA++ R+ L S G+ Sbjct: 368 LSFKTFGEAIPPQYAIKVLDELTDGKAIISTGVGQHQMWAAQFYNYKKPRQWLSSGGLGA 427 Query: 408 MANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVA 467 M +P A+GA P+ VV + GDG F M + + ++ LPVK+++ NN LG V Sbjct: 428 MGFGLPAAIGASVANPDAIVVDIDGDGSFIMNVQELATIRVENLPVKVLLLNNQHLGMVM 487 Query: 468 M-------EMKAGGYLTDGTELHDT--NFARIAEACGITGIRVEKASEVDEALQRAFSID 518 +A +L D + + N A ACGI RV K +++ EA+Q Sbjct: 488 QWEDRFYKANRAHTFLGDPAQEDEIFPNMLLFAAACGIPAARVTKKADLREAIQTMLDTP 547 Query: 519 GPVLVDVVVAKEELAIP 535 GP L+DV+ +E +P Sbjct: 548 GPYLLDVICPHQEHVLP 564 >6DEO-A nrPDB Length = 682 Score = 179 bits (453), Expect = 4e-45, Method: Compositional matrix adjust. Identities = 141/550 (25%), Positives = 253/550 (46%), Gaps = 35/550 (6%) Query: 18 VKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQLSGELAVCAGSCGPG 77 V ++G G ++ + D++ +++ RHE+ A A A+ SG+ V + GPG Sbjct: 102 VDTVFGYAGGAILPVFDAIYNSDKFKFVLPRHEQGAGHMAEGYARASGKPGVVLVTSGPG 161 Query: 78 NLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFRECSHYCELVSSPEQI 137 ++I + D + VP++ + +P++ IG+ FQE + R C+ + +V + ++ Sbjct: 162 ATNVITPMADALMDGVPLVVFSGQVPTTAIGTDAFQEADIVGISRSCTKWNVMVKNVAEL 221 Query: 138 PQVLAIAMRKAVLNR-GVSVVVLPGDVAL----KPAPEGATMHWYHAPQ----PVVTPEE 188 P+ + A A R G +V LP DV + P T+ Q V Sbjct: 222 PRRINEAFEIATTGRPGPVLVDLPKDVTASILRESIPINTTLPSNALSQITKKAVSEFTS 281 Query: 189 EELRKLAQLLRYSSNIALMCGSGCAGAH---KELVEFAGKIKAPIVHALRGKEHVEYDNP 245 E +++ A +L + + G+G K L E A K P+ L+G + +P Sbjct: 282 EAIKRAANILNKAKKPIIYAGAGILNNEQGPKLLKELADKANIPVTTTLQGLGAFDQRDP 341 Query: 246 YDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPYRA------FYPTDAK---------IIQ 290 + M G+ G ++ + NAD ++ LG +F R F P +AK I+ Sbjct: 342 KSLDMLGMHGSAAANTAIQNADCIIALGARFDDRVTGNISKFAP-EAKLAASEGRGGILH 400 Query: 291 IDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGLDDLA 350 +I+P +I + A+ GD+ + L++ +PLV+ +R + +++ L Sbjct: 401 FEISPKNINKVVEATEAIEGDVTANLQSFIPLVDSIENRPEWFNKINEWKKKYPYSYQLE 460 Query: 351 KPSEKAIHPQYLAQQISHFAA---DDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGS 407 P I PQ L ++IS A + I T VG +WAA++ R ++ S G+ Sbjct: 461 TPGS-LIKPQTLIKEISDQAQTYNKEVIVTTGVGQHQMWAAQHFTWTQPRTMITSGGLGT 519 Query: 408 MANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVA 467 M +P A+GAQ +P+ V+ + GD F+M + + S VQ P+K+ V NN G V Sbjct: 520 MGYGLPAAIGAQVAKPDAIVIDIDGDASFNMTLTELSSAVQAGAPIKVCVLNNEEQGMVT 579 Query: 468 MEMKAGGYLTDGTELHDTN--FARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDV 525 + ++ Y + H +N F ++AE+ + GIR+ E+ ++ PVL++V Sbjct: 580 -QWQSLFYEHRYSHTHQSNPDFMKLAESMNVKGIRITNQQELKSGVKEFLDATEPVLLEV 638 Query: 526 VVAKEELAIP 535 +V K+ +P Sbjct: 639 IVEKKVPVLP 648 >1T9B-A nrPDB Length = 677 Score = 179 bits (453), Expect = 4e-45, Method: Compositional matrix adjust. Identities = 142/553 (25%), Positives = 251/553 (45%), Gaps = 41/553 (7%) Query: 18 VKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQLSGELAVCAGSCGPG 77 V ++G G ++ + D+++ ++ +HE+ A A A+ SG+ V + GPG Sbjct: 97 VDTVFGYPGGAILPVYDAIHNSDKFNFVLPKHEQGAGHMAEGYARASGKPGVVLVTSGPG 156 Query: 78 NLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFRECSHYCELVSSPEQI 137 +++ + D + +P++ +P+S IG+ FQE + R C+ + +V S E++ Sbjct: 157 ATNVVTPMADAFADGIPMVVFTGQVPTSAIGTDAFQEADVVGISRSCTKWNVMVKSVEEL 216 Query: 138 PQVLAIAMRKAVLNR-GVSVVVLPGDVAL----KPAPEGATMHWYHAPQPVVTPEEE--- 189 P + A A R G +V LP DV P P T+ Q ++E Sbjct: 217 PLRINEAFEIATSGRPGPVLVDLPKDVTAAILRNPIPTKTTLPSNALNQLTSRAQDEFVM 276 Query: 190 -ELRKLAQLLRYSSNIALMCGSGC---AGAHKELVEFAGKIKAPIVHALRGKEHVEYDNP 245 + K A L+ + L G+G A + L E + + + P+ L+G + ++P Sbjct: 277 QSINKAADLINLAKKPVLYVGAGILNHADGPRLLKELSDRAQIPVTTTLQGLGSFDQEDP 336 Query: 246 YDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPYRA--------------FYPTDAKIIQI 291 + M G+ G ++ + NAD ++ +G +F R II Sbjct: 337 KSLDMLGMHGCATANLAVQNADLIIAVGARFDDRVTGNISKFAPEARRAAAEGRGGIIHF 396 Query: 292 DINPASIGAHSKVDMALVGDIKSTL----RALLPLVEEKADRKFLDKALEDYRDARKGLD 347 +++P +I + +A+ GD + L + P+ E ++K ++Y A Sbjct: 397 EVSPKNINKVVQTQIAVEGDATTNLGKMMSKIFPVKERSEWFAQINKWKKEYPYAY---- 452 Query: 348 DLAKPSEKAIHPQYLAQQISHFAADDA---IFTCDVGTPTVWAARYLKMNGKRRLLGSFN 404 + + I PQ + +++S A D I T VG +WAA++ + S Sbjct: 453 -MEETPGSKIKPQTVIKKLSKVANDTGRHVIVTTGVGQHQMWAAQHWTWRNPHTFITSGG 511 Query: 405 HGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLG 464 G+M +P A+GAQ +PE V+ + GD F+M + + S VQ PVKI++ NN G Sbjct: 512 LGTMGYGLPAAIGAQVAKPESLVIDIDGDASFNMTLTELSSAVQAGTPVKILILNNEEQG 571 Query: 465 FVAMEMKAGGYLTDGTELHDTN--FARIAEACGITGIRVEKASEVDEALQRAFSIDGPVL 522 V + ++ Y + H N F ++AEA G+ G+RV+K E+D L+ S GPVL Sbjct: 572 MVT-QWQSLFYEHRYSHTHQLNPDFIKLAEAMGLKGLRVKKQEELDAKLKEFVSTKGPVL 630 Query: 523 VDVVVAKEELAIP 535 ++V V K+ +P Sbjct: 631 LEVEVDKKVPVLP 643 >5D6R-B nrPDB Length = 579 Score = 165 bits (418), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 142/535 (26%), Positives = 249/535 (46%), Gaps = 20/535 (3%) Query: 6 AAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQLSG 65 A + LE+ GV++++G+ G ++ + DSL +I + RHE AAF A A +++G Sbjct: 34 ADLVVSQLEAQGVRQVFGIPGAKIDKVFDSLLD-SSIRIIPVRHEANAAFMAAAVGRITG 92 Query: 66 ELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFRECS 125 + V + GPG +LI G+ + PV+A+ + ++ Q +F + Sbjct: 93 KAGVALVTSGPGCSNLITGMATANSEGDPVVALGGAVKRADKAKQVHQSMDTVAMFSPVT 152 Query: 126 HYCELVSSPEQIPQVLAIAMRKAVLNR-GVSVVVLPGDVALKPAPEGATMHWYHAPQPVV 184 Y V++P+ + +V++ A R A R G + V LP DV P G + APQ Sbjct: 153 KYAIEVTAPDALAEVVSNAFRAAEQGRPGSAFVSLPQDVVDGPV-SGKVLPASGAPQMGA 211 Query: 185 TPEEEELRKLAQLLRYSSNIALMCG--SGCAGAHKELVEFAGKIKAPIVHALRGKEHVEY 242 P++ + ++A+L+ + N + G + K L P+ + V Sbjct: 212 APDDA-IDQVAKLIAQAKNPIFLLGLMASQPENSKALRRLLETSHIPVTSTYQAAGAVNQ 270 Query: 243 DN-PYDVGMTGLIGFSSGFHTMMNADTLVLLG---TQFPYRAFYPTDAKIIQIDINPASI 298 DN G GL +G + AD ++ +G ++ + +A ++ ID+ PA Sbjct: 271 DNFSRFAGRVGLFNNQAGDRLLQLADLVICIGYSPVEYEPAMWNSGNATLVHIDVLPAYE 330 Query: 299 GAHSKVDMALVGDIKSTLRALLPLVEEKADRKFL-----DKALEDYRDARKGLDDL-AKP 352 + D+ LVGDI TL L + D + + + L D + R+ LD A+ Sbjct: 331 ERNYTPDVELVGDIAGTLNKL----AQNIDHRLVLSPQAAEILRDRQHQRELLDRRGAQL 386 Query: 353 SEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAM 412 ++ A+HP + + + D T D+G+ +W ARYL R+++ S +M A+ Sbjct: 387 NQFALHPLRIVRAMQDIVNSDVTLTVDMGSFHIWIARYLYSFRARQVMISNGQQTMGVAL 446 Query: 413 PQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAMEMKA 472 P A+GA PER+VV++ GDGGF + + V++K V +++ ++ VA++ + Sbjct: 447 PWAIGAWLVNPERKVVSVSGDGGFLQSSMELETAVRLKANVLHLIWVDNGYNMVAIQEEK 506 Query: 473 GGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDVVV 527 G E +F AE+ G G VE A ++ L+ A +DGP +V + V Sbjct: 507 KYQRLSGVEFGPMDFKAYAESFGAKGFAVESAEALEPTLRAAMDVDGPAVVAIPV 561 >4RJK-A nrPDB Length = 571 Score = 155 bits (393), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 139/539 (25%), Positives = 241/539 (44%), Gaps = 18/539 (3%) Query: 1 MKQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAE 60 +K A + L GV ++G+ G ++ + D+L G E + RHE+ AAF A A Sbjct: 13 VKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVFDALQDKGP-EIIVARHEQNAAFMAQAV 71 Query: 61 AQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQEL 120 +L+G+ V + GPG +L GL + PV+A+A ++ ++ Q L Sbjct: 72 GRLTGKPGVVLVTSGPGASNLATGLLTANTEGDPVVALAGNVIRADRLKRTHQSLDNAAL 131 Query: 121 FRECSHYCELVSSPEQIPQVLAIAMRKAVLNR-GVSVVVLPGDVALKPAPEGATMHWYHA 179 F+ + Y V + IP+ + A R A + G + V P DV + + A Sbjct: 132 FQPITKYSVEVQDVKNIPEAVTNAFRIASAGQAGAAFVSFPQDV-VNEVTNTKNVRAVAA 190 Query: 180 PQ--PVVTPEEEELRKLAQLLRYSSNIALMCGSGCAGAHKELVEFAGKIKAPIVHALR-- 235 P+ P Q + + M G G A K + + K++ P V + Sbjct: 191 PKLGPAADDAISAAIAKIQTAKLPVVLVGMKG-GRPEAIKAVRKLLKKVQLPFVETYQAA 249 Query: 236 GKEHVEYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQ-FPYRAFYPT---DAKIIQI 291 G + ++ Y G GL G + AD ++ +G Y + D II + Sbjct: 250 GTLSRDLEDQY-FGRIGLFRNQPGDLLLEQADVVLTIGYDPIEYDPKFWNINGDRTIIHL 308 Query: 292 DINPASIGAHSKVDMALVGDIKSTLRALL--PLVEEKADRKFLDKALEDYRD-ARKGLDD 348 D A I + D+ L+GDI ST+ + + E A+R+ K L D + +G Sbjct: 309 DEIIADIDHAYQPDLELIGDIPSTINHIEHDAVKVEFAERE--QKILSDLKQYMHEGEQV 366 Query: 349 LAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSM 408 A HP + +++ + D TCD+G+ +W +RY + L+ S ++ Sbjct: 367 PADWKSDRAHPLEIVKELRNAVDDHVTVTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTL 426 Query: 409 ANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAM 468 A+P A+GA +P +VV++ GDGGF + + V++K P+ +V+N+S VA Sbjct: 427 GVALPWAIGASLVKPGEKVVSVSGDGGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAF 486 Query: 469 EMKAGGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDVVV 527 + T + + + + AE+ G TG+RVE ++ + L++ + +GPV++DV V Sbjct: 487 QQLKKYNRTSAVDFGNIDIVKYAESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPV 545 >2PAN-A nrPDB Length = 616 Score = 152 bits (384), Expect = 4e-37, Method: Compositional matrix adjust. Identities = 139/548 (25%), Positives = 237/548 (43%), Gaps = 33/548 (6%) Query: 12 TLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAA-FAAGAEAQLSGELAVC 70 LE G+ +GV G ++N ++ + G I + RH E A+ A G +G + VC Sbjct: 36 VLEKEGITTAFGVPGAAINPFYSAMRKHGGIRHILARHVEGASHMAEGYTRATAGNIGVC 95 Query: 71 AGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFRECSHYCEL 130 G+ GP +I L+ + +P+L I P + + FQ + + + S Sbjct: 96 LGTSGPAGTDMITALYSASADSIPILCITGQAPRARLHKEDFQAVDIEAIAKPVSKMAVT 155 Query: 131 VSSPEQIPQVLAIAMRKAVLNR-GVSVVVLPGDVALKPAPEGATMHWYHAPQPVVTP--E 187 V +P+VL A R G +V LP DV + M+ P PV P Sbjct: 156 VREAALVPRVLQQAFHLMRSGRPGPVLVDLPFDVQVAEIEFDPDMY---EPLPVYKPAAS 212 Query: 188 EEELRKLAQLLRYSSNIALMCGSGC--AGAHKELVEFAGKIKAPIVHALRGKEHVEYDNP 245 ++ K ++L + ++ G G A A L +FA P++ L G + D+ Sbjct: 213 RMQIEKAVEMLIQAERPVIVAGGGVINADAAALLQQFAELTSVPVIPTLMGWGCIPDDHE 272 Query: 246 YDVGMTGL-IGFSSGFHTMMNADTLVLLGTQFPYRAF-----YPTDAKIIQIDINPASIG 299 GM GL G T++ +D + +G +F R Y KI+ IDI P IG Sbjct: 273 LMAGMVGLQTAHRYGNATLLASDMVFGIGNRFANRHTGSVEKYTEGRKIVHIDIEPTQIG 332 Query: 300 AHSKVDMALVGDIKSTLRALLPLVEE--KADRKFLDKA-LEDYRDARKGLDDLAKPSEKA 356 D+ +V D K+ L L+ + +E KA R K + D + ++ L Sbjct: 333 RVLCPDLGIVSDAKAALTLLVEVAQEMQKAGRLPCRKEWVADCQQRKRTLLRKTHFDNVP 392 Query: 357 IHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAMPQAL 416 + PQ + ++++ D + +G + AA+ L + R + G + +P AL Sbjct: 393 VKPQRVYEEMNKAFGRDVCYVTTIGLSQIAAAQMLHVFKDRHWINCGQAGPLGWTIPAAL 452 Query: 417 GAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFV-----AMEMK 471 G A +P+R VVA+ GD F L+ + Q +P V+ NN+ LG + A +M Sbjct: 453 GVCAADPKRNVVAISGDFDFQFLIEELAVGAQFNIPYIHVLVNNAYLGLIRQSQRAFDMD 512 Query: 472 AGGYLT----DGTEL--HDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDG----PV 521 L + +E+ + + ++AE G IRV K ++ A ++A ++ PV Sbjct: 513 YCVQLAFENINSSEVNGYGVDHVKVAEGLGCKAIRVFKPEDIAPAFEQAKALMAQYRVPV 572 Query: 522 LVDVVVAK 529 +V+V++ + Sbjct: 573 VVEVILER 580 >5AHK-A nrPDB Length = 588 Score = 125 bits (315), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 133/550 (24%), Positives = 240/550 (43%), Gaps = 42/550 (7%) Query: 9 IAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQLS--GE 66 +AK L V + + G + L DS+N +G + +S HE+ AAFAA A ++++ Sbjct: 27 VAKILADNNVLYGFELIGGMITHLVDSINLLGKTKLVSMHHEQGAAFAASAVSRVTHHKT 86 Query: 67 LAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSE------IGSGYFQETHPQEL 120 L + + GPG +LI G+ DC + P + + + + E I FQE L Sbjct: 87 LGLALATSGPGATNLITGIADCWLDSHPCIFLTGQVNTHELKGKRDIRQQGFQELDSVAL 146 Query: 121 FRECSHYCELVSSPEQIPQVLAIAMRKAVLNR-GVSVVVLPGDVALKPAPEGATMHWYHA 179 + Y + S +++ L A++ A R G ++ +P D+ E A ++ Sbjct: 147 VTSITKYAYQIKSADELVPCLRKAIQIAKEGRPGPVLLDIPMDIQRADIDE-ALLNNPMT 205 Query: 180 PQPVVTPEE---EELRKLAQLLRYSSNIALMCGSGC---AGAHK--ELVEFAGKIKAPIV 231 P+P V +L + L+ + L+ G G +G K E +E G P V Sbjct: 206 PEPKVQRPSIAMSDLDFIINKLQNAKKPLLLIGGGAVNSSGFQKWLEQIELRG---IPYV 262 Query: 232 HALRGKEHVEYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPYRAF------YPTD 285 +L+G E ++ + Y +GM G G + H + N D L++LG++ R + + Sbjct: 263 ASLKGAEKIKASDLY-LGMLGAYGTRAANHAVQNCDLLLVLGSRMDVRQTGAQPEDFARN 321 Query: 286 AKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKG 345 A+IIQID+ + D + ++ PL + + AL + Sbjct: 322 AEIIQIDLQEGQLNNRVIADFSYQIELSEYFSRFSPLQIPVNNDWSVWTALLKEKFRVTF 381 Query: 346 LDDLAKPSEKAIHPQYLAQQISHFAADDAI-FTCDVGTPTVWAARYLKMNGKRRLLGSFN 404 +D+ + + P L Q++ A+ + DVG +WAA L++N ++ + S Sbjct: 382 IDEYTTWN---LSPFGLFTQLNKLTERVALDYILDVGNNQMWAAHTLRLNAQQAMHHSGG 438 Query: 405 HGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLG 464 GSM A+P A+GA ++ ++ + GDGG + + + + + KLP+ +V NN LG Sbjct: 439 LGSMGFAIPAAIGA-CYAGKKPIIVITGDGGAQLNIQELDIIARDKLPILTIVMNNHSLG 497 Query: 465 FVA------MEMKAGGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSID 518 V E + +G + + F +I EA + + AL+ Sbjct: 498 MVRGFQEMYFEGRNSSTYWNG---YTSQFKKIGEAYRVESKTIISMQAFSSALESFLESP 554 Query: 519 GPVLVDVVVA 528 P+L++V ++ Sbjct: 555 RPLLLEVSMS 564 >2PGN-A nrPDB Length = 589 Score = 108 bits (271), Expect = 5e-24, Method: Compositional matrix adjust. Identities = 126/549 (22%), Positives = 226/549 (41%), Gaps = 29/549 (5%) Query: 6 AAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEV--AAFAAGAEAQL 63 A I + LE G +++ G G + + ++D+ ++ + + E+ A G Sbjct: 7 ADLIVEALEEYGTEQVVGFIGHTSHFVADAFSKSHLGKRVINPATELGGAWMVNGYNYVK 66 Query: 64 SGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFRE 123 AV A C GNL L + + +P + I + G + P + F Sbjct: 67 DRSAAVGAWHC-VGNLLLHAAMQEARTGRIPAVHIGLNSDGRLAGRSEAAQQVPWQSFTP 125 Query: 124 CSHYCELVSSPEQIPQVLAIAMRKAVLN-RGVSVVVLPGDVALKP------APEGATMHW 176 + + V +++ + + A R A + G + V +P D+ P GAT Sbjct: 126 IARSTQRVERLDKVGEAIHEAFRVAEGHPAGPAYVDIPFDLTADQIDDKALVPRGATR-- 183 Query: 177 YHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSGCA--GAHKELVEFAGKIKAPIVHAL 234 + V+ E++R+ A L + N ++ G G A G + L++ A + P+V Sbjct: 184 ---AKSVLHAPNEDVREAAAQLVAAKNPVILAGGGVARSGGSEALLKLAEMVGVPVVTTS 240 Query: 235 RGKEHVEYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFP----YRAFYPTDAKIIQ 290 G + +G G G+ S M AD +++LG++ + + K + Sbjct: 241 TGAGVFPETHALAMGSAGFCGWKSANDMMAAADFVLVLGSRLSDWGIAQGYITKMPKFVH 300 Query: 291 IDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLD-KALEDYRDA---RKGL 346 +D +PA +G +++V D K+ + L+ ++ + K + + E++R A R Sbjct: 301 VDTDPAVLGTFYFPLLSVVADAKTFMEQLIEVLPGTSGFKAVRYQERENFRQATEFRAAW 360 Query: 347 DDLAKPSEKAI-HPQYLAQ---QISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGS 402 D + E P + + ++ + I D+G T+ + RRL+ S Sbjct: 361 DGWVREQESGDGMPASMFRAMAEVRKVQRPEDIIVTDIGNHTLPMFGGAILQRPRRLVTS 420 Query: 403 FNHGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSV 462 G + P ALGAQ EP +V GDG +F V+ KLPV +VF N Sbjct: 421 MAEGILGCGFPMALGAQLAEPNSRVFLGTGDGALYYHFNEFRVAVEHKLPVITMVFTNES 480 Query: 463 LGFVAMEMKAGGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVL 522 G M + TE + ++ IA+A G G V + ++ ALQRA P L Sbjct: 481 YGANWTLMNHQFGQNNWTEFMNPDWVGIAKAFGAYGESVRETGDIAGALQRAIDSGKPAL 540 Query: 523 VDVVVAKEE 531 +++ V+K + Sbjct: 541 IEIPVSKTQ 549 >4QQ8-A nrPDB Length = 583 Score = 102 bits (255), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 132/564 (23%), Positives = 235/564 (41%), Gaps = 56/564 (9%) Query: 9 IAKTLESAGVKRIWGVTGDSLNGLSDS-LNRMGTIEWMSTRHEEVAAFAAGAEAQLSGEL 67 + +TL AGV+ ++G+ G ++ + + L+ + + TRHE A AA A+ +L Sbjct: 10 VVRTLIKAGVEHLFGLHGIHIDTIFQACLDH--DVPIIDTRHEAAAGHAAEGYARAGAKL 67 Query: 68 AVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQEL------- 120 V + G G + + + + + PVL + GSG ++ L Sbjct: 68 GVALVTAGGGFTNAVTPIANARTDRTPVLFLT--------GSGALRDDETNTLQAGIDQV 119 Query: 121 --FRECSHYCELVSSPEQIPQVLAIAMRKAV-LNRGVSVVVLPGDVALKPAPEGATMHWY 177 + + V + E IP+++ A+R A+ RG ++ LP D+ + E + + Sbjct: 120 AMAAPITKWAHRVMATEHIPRLVMQAIRAALSAPRGPVLLDLPWDILMNQIDEDSVI--- 176 Query: 178 HAPQPVVT-----PEEEELRKLAQLLRYSSNIALMCGSGCAGAHKE--LVEFAGKIKAPI 230 P V++ P+ +L + LLR + ++ GS + ++ L F P+ Sbjct: 177 -IPDLVLSAHGAHPDPADLDQALALLRKAERPVIVLGSEASRTARKTALSAFVAATGVPV 235 Query: 231 VHALRGKEHVEYDNPYDVGMTGLIGFSSGFHTMMNADTLVL-LGTQFPYRA------FYP 283 G + D GL+ F A LVL LG +F P Sbjct: 236 FADYEGLSMLS--GLPDAMRGGLVQNLYSFAKADAAPDLVLMLGARFGLNTGHGSGQLIP 293 Query: 284 TDAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKA---DRKFLDKALEDYR 340 A++IQ+D + +G + + +V D+ T+ AL + A DR + D Sbjct: 294 HSAQVIQVDPDACELGRLQGIALGIVADVGGTIEALAQATAQDAAWPDRGDWCAKVTDLA 353 Query: 341 DARKGLDDLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLL 400 R SE A+HP + +Q I+ D G +W + + + + Sbjct: 354 QERYASIAAKSSSEHALHPFHASQVIAKHVDAGVTVVADGGLTYLWLSEVMS---RVKPG 410 Query: 401 GSFNHG---SMANAMPQALGAQATEPE--RQVVAMCGDGGFSMLMGDFLSVVQMKLPVKI 455 G HG SM ALGAQ + E R+ + + GDG +G+F ++V+ +LP+ + Sbjct: 411 GFLCHGYLNSMGVGFGTALGAQVADLEAGRRTILVTGDGSVGYSIGEFDTLVRKQLPLIV 470 Query: 456 VVFNNSVLGFVA--MEMKAGGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQR 513 ++ NN G+ ++ G GT L + ++ +A A G G V+ AL + Sbjct: 471 IIMNNQSWGWTLHFQQLAVGPNRVTGTRLENGSYHGVAAAFGADGYHVDSVESFSAALAQ 530 Query: 514 AFSIDGPVLVDVVVAKEELAIPPQ 537 A + + P ++V VA + IPP+ Sbjct: 531 ALAHNRPACINVAVALDP--IPPE 552 >2Q28-A nrPDB Length = 564 Score = 101 bits (252), Expect = 7e-22, Method: Compositional matrix adjust. Identities = 121/540 (22%), Positives = 231/540 (42%), Gaps = 32/540 (5%) Query: 9 IAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQLSGELA 68 I + L+ + I+GV G + ++ G I ++ RHE+ A +AA A L+ + Sbjct: 14 IVEALKQNNIDTIYGVVGIPVTDMARHAQAEG-IRYIGFRHEQSAGYAAAASGFLTQKPG 72 Query: 69 VCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSS--EIGSGYFQETHPQELFRECSH 126 +C PG L+ + L + N P++ I+ + ++ G ++E + + Sbjct: 73 ICLTVSAPGFLNGLTALANATVNGFPMIMISGSSDRAIVDLQQGDYEELDQMNAAKPYAK 132 Query: 127 YCELVSSPEQIPQVLAIAMRKAVLNRGVSVVV-LPGDV---ALKPAPEGATMHWYHAPQP 182 V+ P+ + LA A+R +V R V + LP +V ++ T+ P P Sbjct: 133 AAFRVNQPQDLGIALARAIRVSVSGRPGGVYLDLPANVLAATMEKDEALTTIVKVENPSP 192 Query: 183 VVTPEEEELRKLAQLLRYSSNIALMCGSGCA--GAHKELVEFAGKIKAPIVHALRGKEHV 240 + P + + LL + ++ G G A A ++L EF + P + K + Sbjct: 193 ALLPCPKSVTSAISLLAKAERPLIILGKGAAYSQADEQLREFIESAQIPFLPMSMAKGIL 252 Query: 241 EYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPY-----RAFYPTDAKIIQIDINP 295 E +P ++ + NAD ++L+G + + + + D + IQ+DI P Sbjct: 253 EDTHPLSA-------AAARSFALANADVVMLVGARLNWLLAHGKKGWAADTQFIQLDIEP 305 Query: 296 ASIGAHSKVDMALVGDIKSTLRALLPLVEEKAD------RKFLDKALEDYRDARKGLDDL 349 I ++ + + +VGDI S+++ +L +++ R L+ + ++A+K + L Sbjct: 306 QEIDSNRPIAVPVVGDIASSMQGMLAELKQNTFTTPLVWRDILN--IHKQQNAQKMHEKL 363 Query: 350 AKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAAR-YLKMNGKRRLLGSFNHGSM 408 + ++ + L+ + I+ + G T+ AR + M RR L G M Sbjct: 364 STDTQPLNYFNALSAVRDVLRENQDIYLVNEGANTLDNARNIIDMYKPRRRLDCGTWGVM 423 Query: 409 ANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNN-SVLGFVA 467 M A+GA T VVA+ GD F + ++ + LPV IV+FNN + Sbjct: 424 GIGMGYAIGASVTSGS-PVVAIEGDSAFGFSGMEIETICRYNLPVTIVIFNNGGIYRGDG 482 Query: 468 MEMKAGGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDVVV 527 +++ G + LH + ++ +A G V E+ AL P +++VV+ Sbjct: 483 VDLSGAGAPSPTDLLHHARYDKLMDAFRGVGYNVTTTDELRHALTTGIQSRKPTIINVVI 542 >6A50-A nrPDB Length = 549 Score = 86.7 bits (213), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 89/356 (25%), Positives = 161/356 (45%), Gaps = 37/356 (10%) Query: 187 EEEELRKLAQLLRYSSNIALMCGSG--CAGAHKELVEFAGKIKAPI-VHALRGKEHVEYD 243 +++L L + L +SN A++ G A A+ + V A ++KAP+ V + Sbjct: 207 NDQDLDILVKALNSASNPAIVLGPDVDAANANADCVMLAERLKAPVWVAPSAPRCPFPTR 266 Query: 244 NPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPYRAFY------PTDAKIIQIDINPAS 297 +P G+ G ++ + D ++++G FY ++I + +P Sbjct: 267 HPCFRGLMP-AGIAAISQLLEGHDVVLVIGAPVFRYVFYDPGQYLKPGTRLISVTCDPLE 325 Query: 298 IGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGLDDLAKPSEKA- 356 A + + A+V DI + AL LVEE + R+ A E AK + A Sbjct: 326 -AARAPMGDAIVADIGAMASALANLVEESS-RQLPTAAPEP-----------AKVDQDAG 372 Query: 357 -IHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNH---GSMANAM 412 +HP+ + ++ A ++AI+ + + T + L M R GS+ G + A+ Sbjct: 373 RLHPETVFDTLNDMAPENAIYLNESTSTTAQMWQRLNM----RNPGSYYFCAAGGLGFAL 428 Query: 413 PQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLG---FVAME 469 P A+G Q EPERQV+A+ GDG + + + Q +P V+ NN G + A Sbjct: 429 PAAIGVQLAEPERQVIAVIGDGSANYSISALWTAAQYNIPTIFVIMNNGTYGMLRWFAGV 488 Query: 470 MKAGGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDV 525 ++A G ++ +F +A+ G+ ++ + ++ +LQ A S GPVL++V Sbjct: 489 LEAEN--VPGLDVPGIDFRALAKGYGVQALKADNLEQLKGSLQEALSAKGPVLIEV 542 >5NPU-A nrPDB Length = 563 Score = 86.3 bits (212), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 127/563 (22%), Positives = 233/563 (41%), Gaps = 55/563 (9%) Query: 1 MKQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAE 60 M TV Y+A L G+K + V GD L D L + +E + +E F+A Sbjct: 1 MTYTVGHYLATRLAQIGLKHHFAVAGDYNLVLLDQLLKNKDLEQVYCCNELNCGFSAEGY 60 Query: 61 AQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYF-------- 112 A+ +G + + G L N + + ++PV+ I+ +++ GSG+ Sbjct: 61 ARANG-VGAAVVTFSVGALSAFNAIGGAYAENLPVILISGAPNTNDHGSGHILHHTIGTT 119 Query: 113 QETHPQELFRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDVALKP-APEG 171 + E+ ++ + ++ E P ++ A+R A+ + + + + +VA +P A G Sbjct: 120 DYGYQLEMAKQITCAAVSITHAEDAPALIDHAIRTALREKKPAYIEIACNVAAQPCARPG 179 Query: 172 ATMHWYHAPQPVVTPEEEELRKLAQ----LLRYSSNIALMCGSG--CAGAHKELVEFAGK 225 + P T +EE L+ + + L+ G AGA + +VE A Sbjct: 180 PVSALLNEP----TSDEETLKAAVEAALDFIEKREKPVLLVGGKLRAAGAEEAVVELADA 235 Query: 226 IKAPIVHALRGKEHVEYDNPYDVGMTGLIGFSSGFHTMMN-ADTLVLLGTQF-PYRAF-- 281 + + K D+P VG S G +++ AD ++ LG F Y Sbjct: 236 LGCAVATMAAAKSFFPEDHPGYVGTYWGEVSSPGVEEIVDWADGIICLGPVFNDYSTVGW 295 Query: 282 --YPTDAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDY 339 +P ++ +D + ++G + L K L AL V +K D L+ + Sbjct: 296 TAWPKGENVVLVDPHHITVGGEEFTGIHL----KDFLTALTERVPKK------DATLDQF 345 Query: 340 RDARKGLDDLAK-PSEKAIHP---QYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNG 395 + AR G K P+ P L +QI + + G A R +G Sbjct: 346 K-ARVGKPAAEKVPAADPNAPLTRAELCRQIQGLLNPNTTLIAETGDSWFNAMRMKLPHG 404 Query: 396 KRRLLGSFNHGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKI 455 R L G + ++P G EPER+ V M GDG F + + +V+ KLP+ I Sbjct: 405 ARVEL-EMQWGHIGWSVPATFGYAVAEPERRNVLMVGDGSFQLTAQEVAQMVRRKLPIII 463 Query: 456 VVFNNSVLGF-VAMEMKAGGYLTDGTELHDTNFARIAEACGIT-----GIRVEKASEVDE 509 + NN G+ + +++ G Y + + ++A + E G++ E+ E Sbjct: 464 FLINNR--GYTIEVKIHDGPY----NNIKNWDYAGLMEVFNAEDGKGLGLKATTGGELAE 517 Query: 510 ALQRAFS-IDGPVLVDVVVAKEE 531 A+++A + +GP L++ V+ +++ Sbjct: 518 AIKKALAHREGPTLIECVIDRDD 540 >2VBF-A nrPDB Length = 570 Score = 81.6 bits (200), Expect = 9e-16, Method: Compositional matrix adjust. Identities = 114/519 (21%), Positives = 218/519 (42%), Gaps = 48/519 (9%) Query: 4 TVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQL 63 TV Y+ L G++ I+GV GD D + ++W+ +E A++ A A+ Sbjct: 26 TVGDYLLDRLHELGIEEIFGVPGDYNLQFLDQIISREDMKWIGNANELNASYMADGYAR- 84 Query: 64 SGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSG--YFQETHPQELF 121 + + A + G G L INGL + ++PV+ I P+S++ + + T F Sbjct: 85 TKKAAAFLTTFGVGELSAINGLAGSYAENLPVVEIVGS-PTSKVQNDGKFVHHTLADGDF 143 Query: 122 RECSHYCELVSSPE----------QIPQVLAIAMRKAVLNRGVSVVVLPGDVALKPAPEG 171 + E V++ +I +VL+ +++ R + LP DVA A E Sbjct: 144 KHFMKMHEPVTAARTLLTAENATYEIDRVLSQLLKE----RKPVYINLPVDVAAAKA-EK 198 Query: 172 ATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSGCA--GAHKELVEFAGKIKAP 229 + T E+ L K+ + L+ + ++ G G K + +F + K P Sbjct: 199 PALSLEKESSTTNTTEQVILSKIEESLKNAQKPVVIAGHEVISFGLEKTVTQFVSETKLP 258 Query: 230 IVHALRGKEHVEYDNPYDVGM-TGLIGFSSGFHTMMNADTLVLLG---TQFPYRAF--YP 283 I GK V+ P +G+ G + S + + +AD +++LG T AF + Sbjct: 259 ITTLNFGKSAVDESLPSFLGIYNGKLSEISLKNFVESADFILMLGVKLTDSSTGAFTHHL 318 Query: 284 TDAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDAR 343 + K+I ++I+ I D D ++ + +L L + + +++DK E++ Sbjct: 319 DENKMISLNIDEGIIFNKVVEDF----DFRAVVSSLSELKGIEYEGQYIDKQYEEFI--- 371 Query: 344 KGLDDLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSF 403 PS + L Q + + + GT + + A + + R +G Sbjct: 372 --------PSSAPLSQDRLWQAVESLTQSNETIVAEQGT-SFFGASTIFLKSNSRFIGQP 422 Query: 404 NHGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDF-LSVVQMKLPVKIVVFNNSV 462 GS+ P ALG+Q + E + + GDG + + + LS+ + P+ ++ N+ Sbjct: 423 LWGSIGYTFPAALGSQIADKESRHLLFIGDGSLQLTVQELGLSIREKLNPICFIINND-- 480 Query: 463 LGFVAMEMKAGGYLTDGTELHDTNFARIAEACGITGIRV 501 G+ +E + G ++ N++++ E G T RV Sbjct: 481 -GY-TVEREIHGPTQSYNDIPMWNYSKLPETFGATEDRV 517 >1UPC-A nrPDB Length = 573 Score = 79.7 bits (195), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 120/527 (22%), Positives = 206/527 (39%), Gaps = 57/527 (10%) Query: 42 IEWMSTRHEEVAAFAAGAEAQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAH 101 I+++ TRHE A AA A+++G C + GPG +L G+ + PV+A+AA Sbjct: 49 IDFVLTRHEFTAGVAADVLARITGRPQACWATLGPGMTNLSTGIATSVLDRSPVIALAAQ 108 Query: 102 IPSSEIGSGYFQETH----PQELFRECSHYCELVSSPEQIPQVLAIAMRKAVLNR-GVSV 156 S +I + +TH + S Y + P +I ++ A+ A+ G S Sbjct: 109 SESHDI---FPNDTHQCLDSVAIVAPMSKYAVELQRPHEITDLVDSAVNAAMTEPVGPSF 165 Query: 157 VVLPGDVALKPAPEGATMHWYHAPQPVVTPEEEELRKLAQ-----------LLRYSSNIA 205 + LP D L + EG P P + + +A LL + + Sbjct: 166 ISLPVD--LLGSSEGIDTT---VPNPPANTPAKPVGVVADGWQKAADQAAALLAEAKHPV 220 Query: 206 LMCGSGC--AGAHKELVEFAGKIKAPIVHALRGKEHVEYDNPYDVG-----MTGLIGFSS 258 L+ G+ +GA + A ++ P++ K + + + G M G++ F + Sbjct: 221 LVVGAAAIRSGAVPAIRALAERLNIPVITTYIAKGVLPVGHELNYGAVTGYMDGILNFPA 280 Query: 259 GFHTMMNADTLVL-LGTQF-----PYRAFYPTDAKIIQIDINPASIGAHSKVDMALVGDI 312 TM LVL +G + P + K ++I I + D+ +V D+ Sbjct: 281 -LQTMFAPVDLVLTVGYDYAEDLRPSMWQKGIEKKTVRISPTVNPIPRVYRPDVDVVTDV 339 Query: 313 KSTLRALLPLVE--EKADRKFLDKALEDYRDARKGLDDLAKPSEKAIHPQYLAQQISHF- 369 L VE E A F K D R + + E + Q I Sbjct: 340 -------LAFVEHFETATASFGAKQRHDIEPLRARIAEFLADPETYEDGMRVHQVIDSMN 392 Query: 370 -----AAD--DAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAMPQALGAQATE 422 AA+ + D+G + + + + L S S +P A+GAQ Sbjct: 393 TVMEEAAEPGEGTIVSDIGFFRHYGVLFARADQPFGFLTSAGCSSFGYGIPAAIGAQMAR 452 Query: 423 PERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAMEMKAGGYLT--DGT 480 P++ + GDGGF D ++ ++ LP+ VV NN G + + G + + Sbjct: 453 PDQPTFLIAGDGGFHSNSSDLETIARLNLPIVTVVVNNDTNGLIELYQNIGHHRSHDPAV 512 Query: 481 ELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDVVV 527 + +F +AEA G+ R E+ AL++ + P L++V V Sbjct: 513 KFGGVDFVALAEANGVDATRATNREELLAALRKGAELGRPFLIEVPV 559 >4ZP1-A nrPDB Length = 568 Score = 77.4 bits (189), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 121/563 (21%), Positives = 233/563 (41%), Gaps = 52/563 (9%) Query: 1 MKQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAA-GA 59 M TV Y+A+ L G+K + V GD L D+L +E + +E F+A G Sbjct: 1 MSYTVGTYLAERLVQIGLKHHFAVAGDYNLVLLDNLLLNKNMEQVYCCNELNCGFSAEGY 60 Query: 60 EAQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYF------- 112 AV S G L + + + ++PV+ I+ +++ +G+ Sbjct: 61 ARAKGAAAAVVTYSVGA--LSAFDAIGGAYAENLPVILISGAPNNNDHAAGHVLHHALGK 118 Query: 113 QETHPQ-ELFRECSHYCELVSSPEQIP----QVLAIAMRK---AVLNRGVSVVVLPGDVA 164 + H Q E+ + + E + +PE+ P V+ A+R+ L ++ +P Sbjct: 119 TDYHYQLEMAKNITAAAEAIYTPEEAPAKIDHVIKTALREKKPVYLEIACNIASMP---C 175 Query: 165 LKPAPEGATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSG--CAGAHKELVEF 222 P P A + + + + EE K + +A++ GS AGA + V+F Sbjct: 176 AAPGPASALFNDEASDEASLNAAVEETLKF---IANRDKVAVLVGSKLRAAGAEEAAVKF 232 Query: 223 AGKIKAPIVHALRGKEHVEYDNPYDVGMT-GLIGFSSGFHTMMNADTLVLLGTQFPYRAF 281 A + + K +NP+ +G + G + + TM AD ++ L F Sbjct: 233 ADALGGAVATMAAAKSFFPEENPHYIGTSWGEVSYPGVEKTMKEADAVIALAPVF---ND 289 Query: 282 YPTDAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRD 341 Y T D + V + + L+ L + +K +K AL+ ++ Sbjct: 290 YSTTGWTDIPDPKKLVLAEPRSVVVNGIRFPSVHLKDYLTRLAQKVSKK--TGALDFFKS 347 Query: 342 ARKGLDDLAKPSEKA--IHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRL 399 G A P++ + + +A+Q+ + + G + + A+ +K+ R+ Sbjct: 348 LNAGELKKAAPADPSAPLVNAEIARQVEALLTPNTTVIAETGD-SWFNAQRMKLPNGARV 406 Query: 400 LGSFNHGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFN 459 G + ++P A G PER+ + M GDG F + + +V++KLPV I + N Sbjct: 407 EYEMQWGHIGWSVPAAFGYAVGAPERRNILMVGDGSFQLTAQEVAQMVRLKLPVIIFLIN 466 Query: 460 NSVLGF-VAMEMKAGGYLTDGTELHDTNFARIAE---------ACGITGIRVEKASEVDE 509 N G+ +A+ + G Y + + ++A + E + G++ + E+ E Sbjct: 467 N--YGYTIAVMIHDGPY----NNIKNWDYAGLMEVFNGNGGYDSGAGKGLKAKTGGELAE 520 Query: 510 ALQRAF-SIDGPVLVDVVVAKEE 531 A++ A + DGP L++ + +E+ Sbjct: 521 AIKVALANTDGPTLIECFIGRED 543 >2JI6-A nrPDB Length = 568 Score = 76.3 bits (186), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 124/543 (22%), Positives = 215/543 (39%), Gaps = 45/543 (8%) Query: 13 LESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQLSGELAVCAG 72 L+ + ++GV G + L+ G + S RHE+ A +AA + G+ VC Sbjct: 20 LKMNDIDTMYGVVGIPITNLARMWQDDGQ-RFYSFRHEQHAGYAASIAGYIEGKPGVCLT 78 Query: 73 SCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSE-----IGSGYFQETHPQELFRECSHY 127 PG L+ + L N P++ ++ SSE + G ++E + R Sbjct: 79 VSAPGFLNGVTSLAHATTNCFPMILLSG---SSEREIVDLQQGDYEEMDQMNVARPHCKA 135 Query: 128 CELVSSPEQIPQVLAIAMRKAVLNRGVSVVV-LPGDV-ALKPAPEGATMHWYHA--PQPV 183 ++S + IP +A A+R AV R V V LP + + E A + P P Sbjct: 136 SFRINSIKDIPIGIARAVRTAVSGRPGGVYVDLPAKLFGQTISVEEANKLLFKPIDPAPA 195 Query: 184 VTPEEEELRKLAQLLRYSSNIALMCGSGCAGAH-----KELVEFAGKIKAPIVHALRGKE 238 P E+ + + A L++ + +M G G A A + LVE G P + K Sbjct: 196 QIPAEDAIARAADLIKNAKRPVIMLGKGAAYAQCDDEIRALVEETG---IPFLPMGMAKG 252 Query: 239 HVEYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPY-------RAFYPTDAKIIQI 291 + ++P ++ + D VL+G + + + + K +QI Sbjct: 253 LLPDNHPQSA-------AATRAFALAQCDVCVLIGARLNWLMQHGKGKTWGDELKKYVQI 305 Query: 292 DINPASIGAHSKVDMALVGDIKSTLRALLPLVE--EKADRKFLDKALEDYRDARK----G 345 DI + ++ + +VGDIKS + L ++ KAD ++ AL+ D K G Sbjct: 306 DIQANEMDSNQPIAAPVVGDIKSAVSLLRKALKGAPKADAEWT-GALKAKVDGNKAKLAG 364 Query: 346 LDDLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYL-KMNGKRRLLGSFN 404 PS + L A+ I + G + R + M R+ L S Sbjct: 365 KMTAETPSGMMNYSNSLGVVRDFMLANPDISLVNEGANALDNTRMIVDMLKPRKRLDSGT 424 Query: 405 HGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLG 464 G M M + A A + V+A+ GD F + ++ + LPV +++ NN + Sbjct: 425 WGVMGIGMGYCVAAAAVT-GKPVIAVEGDSAFGFSGMELETICRYNLPVTVIIMNNGGI- 482 Query: 465 FVAMEMKAGGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVD 524 + E + T L + + EA G G +E+ AL+ A + P L++ Sbjct: 483 YKGNEADPQPGVISCTRLTRGRYDMMMEAFGGKGYVANTPAELKAALEEAVASGKPCLIN 542 Query: 525 VVV 527 ++ Sbjct: 543 AMI 545 >2Q5O-A nrPDB Length = 565 Score = 72.0 bits (175), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 111/532 (20%), Positives = 207/532 (38%), Gaps = 40/532 (7%) Query: 5 VAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQLS 64 +A + + L+ G + ++G+ GD + + HE FAA A A+ S Sbjct: 23 LAEALLRALKDRGAQAMFGIPGDFALPFFKVAEETQILPLHTLSHEPAVGFAADAAARYS 82 Query: 65 GELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQEL---- 120 L V A + G G +++N + + PV+ I+ ++E +G + L Sbjct: 83 STLGVAAVTYGAGAFNMVNAVAGAYAEKSPVVVISGAPGTTEGNAGLLLHHQGRTLDTQF 142 Query: 121 --FRECSHYCELVSSPEQIPQVLAIAMRKA-VLNRGVSVVVLPGDVALKPAPEGATMHWY 177 F+E + + P + P +A + A +R V + + V + P G W Sbjct: 143 QVFKEITVAQARLDDPAKAPAEIARVLGAARAQSRPVYLEIPRNMVNAEVEPVGDDPAWP 202 Query: 178 HAPQPVVTPEEEELRKLAQLLRYSSNIALMCGS-GCAGAHKELVEFAGKIKAPIVHALRG 236 + +E LA + +S + ++C G ++ E A ++ P+V G Sbjct: 203 VDRDALAACADE---VLAAMRSATSPVLMVCVEVRRYGLEAKVAELAQRLGVPVVTTFMG 259 Query: 237 KEHV-EYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPYRAFYPTDAKI-----IQ 290 + + + P G+ G + + +D L LLG F + KI I Sbjct: 260 RGLLADAPTPPLGTYIGVAGDAEITRLVEESDGLFLLGAILSDTNFAVSQRKIDLRKTIH 319 Query: 291 IDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGLDDLA 350 ++G H+ D+ L G + + L L P +DR K Y GL Sbjct: 320 AFDRAVTLGYHTYADIPLAGLVDALLERLPP-----SDRTTRGKEPHAY---PTGLQADG 371 Query: 351 KPSEKAIHPQYLAQQIS---HFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGS 407 +P I P +A+ ++ + + D+G A + L+ + Sbjct: 372 EP----IAPMDIARAVNDRVRAGQEPLLIAADMGDCLFTAMDMIDAG----LMAPGYYAG 423 Query: 408 MANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVA 467 M +P +GAQ ++++ + GDG F M + + ++ + +++FNN+ + Sbjct: 424 MGFGVPAGIGAQCVSGGKRILTVVGDGAFQMTGWELGNCRRLGIDPIVILFNNASWEMLR 483 Query: 468 MEMKAGGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDG 519 + +L D FA +A G G+RV +E+ AL +AF+ G Sbjct: 484 TFQPESAF----NDLDDWRFADMAAGMGGDGVRVRTRAELKAALDKAFATRG 531 >4Q9D-A nrPDB Length = 545 Score = 70.9 bits (172), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 117/499 (23%), Positives = 200/499 (40%), Gaps = 43/499 (8%) Query: 50 EEVAAFA-AGAEAQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAH-IPSSEI 107 +E +A A A AQ +G+ A+ G + + L +R + P++ A + Sbjct: 49 QEASALAMADGFAQATGKPALVNLHTAAGTGNAMGSLVAAYRANTPLIITAGQQTREMSV 108 Query: 108 GSGYFQETHPQELFRECSHYCELVSSPEQIP----QVLAIAMRKAVLNRGVSVVVLPGDV 163 Y + + + + E +P Q A+AM+ + G + +P D Sbjct: 109 VDPYLNNPDATTMPKPWVKWSYEPARAEDVPAAFMQAYAVAMQPPM---GPVFLSIPLDD 165 Query: 164 ALKPAPEGATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSGC--AGAHKELVE 221 KPA A + V P+ E L + A+ + + + L+ G AGA +E Sbjct: 166 WDKPALGPAAVRSVST---RVAPDAERLAQFAERINAAKHPMLVLGPEVDRAGAWDAGIE 222 Query: 222 FAGKIKAPI-VHALRGKEHVEYDNPYDVGMTGLIGFSSGFHTMMNA-DTLVLLGTQ---- 275 FA K+ AP+ AL + D+P G + +G ++A D +V++G + Sbjct: 223 FAEKLGAPVHASALPDRMSFPEDHPLYAGPLPMT--IAGVEQAVSAYDLVVVVGAEVFRY 280 Query: 276 FPYRA--FYPTDAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLD 333 +PY + P ++QI +P A + V +LVGD+ L L L++ DR Sbjct: 281 YPYVPGEYLPEGTDLLQITADPHR-SAVAPVGDSLVGDVGIALSRLTELIDTPDDR-VPP 338 Query: 334 KALEDYRDARKGLDDLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKM 393 K L R+ D+ PS + + + +S+ DDA + + + +L Sbjct: 339 KPL-----VRQRHSDI--PSTAPMTSNAVYEVLSNVKPDDAAVVMESTSTMLDLFTWLPT 391 Query: 394 NGKRRLLGSFNHG---SMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMK 450 + + G + A+ ALG +A +R VVA GDG F + + Q K Sbjct: 392 THPASFFATGSGGIGWGVPAAVGIALGDRARGVDRTVVATIGDGSFQYSIQAIWTAAQHK 451 Query: 451 LPVKIVVFNNS----VLGFVAMEMKAGGYLTDGTELHDTNFARIAEACGITGIRVEKASE 506 LP+ VV N + F +E G +L + + IA G VE Sbjct: 452 LPIVFVVLRNGEYAILKSFADLEKTPN---VPGLQLPGLDISSIAAGFGCRTATVESTDM 508 Query: 507 VDEALQRAFSIDGPVLVDV 525 ++ L+ A DGP ++ V Sbjct: 509 LEAELKTALQADGPTVLVV 527 >1OVM-A nrPDB Length = 552 Score = 67.0 bits (162), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 127/567 (22%), Positives = 227/567 (40%), Gaps = 71/567 (12%) Query: 5 VAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQLS 64 VA Y+ L G ++GV GD D + I W+ +E A++AA A+ Sbjct: 7 VADYLLDRLTDCGADHLFGVPGDYNLQFLDHVIDSPDICWVGCANELNASYAADGYARCK 66 Query: 65 GELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSG-YFQETHPQELFRE 123 G A + G G L +NG+ + HVPVL I ++ G T FR Sbjct: 67 G-FAALLTTFGVGELSAMNGIAGSYAEHVPVLHIVGAPGTAAQQRGELLHHTLGDGEFRH 125 Query: 124 CSHYCELVSSPE----------QIPQVLAIAMRKAVLNRGVSVVVLPGDVALKPA--PEG 171 H E ++ + +I +VL +R+ R ++LP DVA K A P Sbjct: 126 FYHMSEPITVAQAVLTEQNACYEIDRVLTTMLRE----RRPGYLMLPADVAKKAATPPVN 181 Query: 172 ATMH-WYHAPQPVVTPEEEELRKLAQLLRYSSNIA--LMCGSGCAGAHKELVEFAGKIKA 228 A H HA + + + + ++ +A L+ G A ++ V+ + Sbjct: 182 ALTHKQAHADSACLKAFRDAAENKLAMSKRTALLADFLVLRHGLKHALQKWVK-----EV 236 Query: 229 PIVHA--LRGKEHVEYDNPYDVGMTGLIGFSSGFHT-------MMNADTLVLLGTQFPYR 279 P+ HA L GK +D G G SG + + ADT++ +GT+F Sbjct: 237 PMAHATMLMGK------GIFDERQAGFYGTYSGSASTGAVKEAIEGADTVLCVGTRFTDT 290 Query: 280 -----AFYPTDAKIIQIDINPASIGAHSKVDMALVG-DIKSTLRALLPLVEEKADRKFLD 333 T A+ I++ + A +G D+ G + + L+ L ++ + Sbjct: 291 LTAGFTHQLTPAQTIEVQPHAARVG-----DVWFTGIPMNQAIETLVELCKQHVHAGLMS 345 Query: 334 KALEDYRDARKGLDDLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKM 393 + G +P + ++ + + + F I D GT + + A L++ Sbjct: 346 SS--------SGAIPFPQP-DGSLTQENFWRTLQTFIRPGDIILADQGT-SAFGAIDLRL 395 Query: 394 NGKRRLLGSFNHGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPV 453 + GS+ + A GAQ P R+V+ + GDG + + + S+++ K Sbjct: 396 PADVNFIVQPLWGSIGYTLAAAFGAQTACPNRRVIVLTGDGAAQLTIQELGSMLRDKQHP 455 Query: 454 KIVVFNNSVLGFVAMEMKAGGYLTDGTELHDTNFARIAEACGIT----GIRVEKASEVDE 509 I+V NN G+ +E G ++ N+ I +A + RV +A ++ + Sbjct: 456 IILVLNNE--GYT-VERAIHGAEQRYNDIALWNWTHIPQALSLDPQSECWRVSEAEQLAD 512 Query: 510 ALQRAFSIDGPVLVDVVVAKEELAIPP 536 L++ + L++V++ K + IPP Sbjct: 513 VLEKVAHHERLSLIEVMLPKAD--IPP 537 >5EUJ-A nrPDB Length = 573 Score = 63.9 bits (154), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 116/556 (20%), Positives = 231/556 (41%), Gaps = 52/556 (9%) Query: 4 TVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAA-GAEAQ 62 TV Y+A+ L G+K + V GD L D L +E + +E F+A G Sbjct: 3 TVGMYLAERLAQIGLKHHFAVAGDYNLVLLDQLLLNKDMEQVYCCNELNCGFSAEGYARA 62 Query: 63 LSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYF--------QE 114 A+ S G + +N + + ++PV+ I+ +++ G+G+ Sbjct: 63 RGAAAAIVTFSVGA--ISAMNAIGGAYAENLPVILISGSPNTNDYGTGHILHHTIGTTDY 120 Query: 115 THPQELFRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDVA----LKPAPE 170 + E+ + + E + S E+ P + +R A+ R + + + +VA ++P P Sbjct: 121 NYQLEMVKHVTCAAESIVSAEEAPAKIDHVIRTALRERKPAYLEIACNVAGAECVRPGPI 180 Query: 171 GATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSGC--AGAHKELVEFAGKIKA 228 + + Q VT + + L+ N+ ++ GS A A K+ V A ++ Sbjct: 181 NSLLRELEVDQTSVTAA---VDAAVEWLQDRQNVVMLVGSKLRAAAAEKQAVALADRLGC 237 Query: 229 PIVHALRGKEHVEYDNPYDVGMT-GLIGFSSGFHTMMNADTLVLLGTQFPYRAF-----Y 282 + K D+P G+ G + + NAD ++ L F A + Sbjct: 238 AVTIMAAAKGFFPEDHPNFRGLYWGEVSSEGAQELVENADAILCLAPVFNDYATVGWNSW 297 Query: 283 PTDAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDA 342 P ++ +D + + S ++L ST A L EKA + + + Sbjct: 298 PKGDNVMVMDTDRVTFAGQSFEGLSL-----STFAAALA---EKAPSR--PATTQGTQAP 347 Query: 343 RKGLDDLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGS 402 G++ A+P+ + + + +QI D T + G A+R + + G R+ Sbjct: 348 VLGIE-AAEPNAPLTNDE-MTRQIQSLITSDTTLTAETGDSWFNASR-MPIPGGARVELE 404 Query: 403 FNHGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSV 462 G + ++P A G PER+ + M GDG F + + +++ ++PV I + NN Sbjct: 405 MQWGHIGWSVPSAFGNAVGSPERRHIMMVGDGSFQLTAQEVAQMIRYEIPVIIFLINNR- 463 Query: 463 LGFV-AMEMKAGGYLTDGTELHDTNFARIAEACGIT-----GIRVEKASEVDEALQRAF- 515 G+V + + G Y + + N+A + + G++ +E++ A+++A Sbjct: 464 -GYVIEIAIHDGPY----NYIKNWNYAGLIDVFNDEDGHGLGLKASTGAELEGAIKKALD 518 Query: 516 SIDGPVLVDVVVAKEE 531 + GP L++ +A+++ Sbjct: 519 NRRGPTLIECNIAQDD 534 >4K9Q-A nrPDB Length = 539 Score = 60.1 bits (144), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 83/363 (22%), Positives = 150/363 (41%), Gaps = 35/363 (9%) Query: 186 PEEEELRKLAQLLRYSSNIALMCGSGCA--GAHKELVEFAGKIKAPIVHA-LRGKEHVEY 242 P+ +++++ AQ + S N L+ GS A A + + FA ++ AP+ A + Sbjct: 182 PDPDKVKEFAQRITASKNPLLIYGSDIARSQAWSDGIAFAERLNAPVWAAPFAERTPFPE 241 Query: 243 DNP-YDVGMTGLIGFSSGFHTMMNADTLVLLGTQ----FPYRA--FYPTDAKIIQIDINP 295 D+P + +T IG S + D +V++G +P+ A F P + ++Q+ +P Sbjct: 242 DHPLFQGALTSGIG--SLEKQIQGHDLIVVIGAPVFRYYPWIAGQFIPEGSTLLQVSDDP 299 Query: 296 ASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGLDDLAKPSEK 355 ++ + + V +LV D K L L L++++ +K R D A P Sbjct: 300 -NMTSKAVVGDSLVSDSKLFLIEALKLIDQR------EKNNTPQRSPMTKEDRTAMP--- 349 Query: 356 AIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAMPQA 415 + P + + + + + + + + ++N +F G + +P A Sbjct: 350 -LRPHAVLEVLKENSPKEIVLVEECPSIVPLMQDVFRINQPDTFY-TFASGGLGWDLPAA 407 Query: 416 ----LGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLG----FVA 467 LG + + R VV + GDG F + + VQ K V VVF N G F Sbjct: 408 VGLALGEEVSGRNRPVVTLMGDGSFQYSVQGIYTGVQQKTHVIYVVFQNEEYGILKQFAE 467 Query: 468 MEMKAGGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDVVV 527 +E G +L + +A G ++VE E+ A A S G ++ V + Sbjct: 468 LEQTPN---VPGLDLPGLDIVAQGKAYGAKSLKVETLDELKTAYLEALSFKGTSVIVVPI 524 Query: 528 AKE 530 KE Sbjct: 525 TKE 527 >6EFG-A nrPDB Length = 563 Score = 55.8 bits (133), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 102/501 (20%), Positives = 192/501 (38%), Gaps = 78/501 (15%) Query: 4 TVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQL 63 T+ Y+ + L+ V+ I+G+ GD L D++ + + W +E AA+AA A+L Sbjct: 5 TLGRYLFERLKQVEVQTIFGLPGDFNLSLLDNIYEVPGMRWAGNANELNAAYAADGYARL 64 Query: 64 SGELAVCAGSCGPGNLHLINGLFDCH--------RNHVPVLAIAAH--IPSSEIGSGYFQ 113 G ++ + G G L +NG+ + VP ++ A + +G+G F Sbjct: 65 KG-MSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSVSSQAKQLLLHHTLGNGDFT 123 Query: 114 ETH--PQELFRECSHYCELVSSPEQI------------PQVLAIAMRKAVLNRGVSVVVL 159 H + + ++ ++P +I P L + L S++ Sbjct: 124 VFHRMSSNISETTAMITDINTAPAEIDRCIRTTYVSQRPVYLGLPANLVDLTVPASLLDT 183 Query: 160 PGDVALKPA-PEGATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSGCA--GAH 216 P D++LKP PE EEE + + QL++ + N ++ + C+ A Sbjct: 184 PIDLSLKPNDPEA---------------EEEVIENVLQLIKEAKNPVILADACCSRHDAK 228 Query: 217 KELVEFAGKIKAPIVHALRGKEHVEYDNPYDVGM-TGLIGFSSGFHTMMNADTLVLLGTQ 275 E + + P GK ++ +P G+ G + + + +AD ++ +G Sbjct: 229 AETKKLIDLTQFPAFVTPMGKGSIDEKHPRFGGVYVGTLSSPAVKEAVESADLVLSVG-- 286 Query: 276 FPYRAFYPTDAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKA 335 A + + S +K + D A P V+ K L K Sbjct: 287 ----------ALLSDFNTGSFSYSYKTKNIVEFHSDYTKIRSATFPGVQMKFA---LQKL 333 Query: 336 LEDYRDARKGLDDLAKPSE----------KAIHPQYLAQQISHFAADDAIFTCDVGTPTV 385 L DA KG + PSE + +++ Q+ F + + + GT Sbjct: 334 LTKVADAAKGYKPVPVPSEPEHNEAVADSTPLKQEWVWTQVGEFLREGDVVITETGTSAF 393 Query: 386 WAARYLKMNG----KRRLLGS--FNHGSMANAMPQALGAQATEPERQVVAMCGDGGFSML 439 + N + L GS F G+ A A A+ +P+++V+ GDG + Sbjct: 394 GINQTHFPNNTYGISQVLWGSIGFTTGATLGA---AFAAEEIDPKKRVILFIGDGSLQLT 450 Query: 440 MGDFLSVVQMKLPVKIVVFNN 460 + + ++++ L + V NN Sbjct: 451 VQEISTMIRWGLKPYLFVLNN 471 >2VBI-A nrPDB Length = 566 Score = 52.4 bits (124), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 121/573 (21%), Positives = 221/573 (38%), Gaps = 80/573 (13%) Query: 1 MKQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAE 60 M TV Y+A+ L G+K + V GD L D L ++ + +E F+A Sbjct: 1 MTYTVGMYLAERLVQIGLKHHFAVAGDYNLVLLDQLLLNKDMKQIYCCNELNCGFSAEGY 60 Query: 61 AQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYF-------- 112 A+ +G A + G + +N L + ++PV+ I+ S++ G+G+ Sbjct: 61 ARSNGAAAAVV-TFSVGAISAMNALGGAYAENLPVILISGAPNSNDQGTGHILHHTIGKT 119 Query: 113 QETHPQELFRECSHYCELV----SSPEQIPQVLAIAMRK---AVLNRGVSVVVLPGDVAL 165 ++ E+ R+ + E + S+P +I V+ A+R+ A L+ ++ P + Sbjct: 120 DYSYQLEMARQVTCAAESITDAHSAPAKIDHVIRTALRERKPAYLDIACNIASEP---CV 176 Query: 166 KPAPEGATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSG--CAGAHKELVEFA 223 +P P + + P+ T + + LL S++ ++ GS A A A Sbjct: 177 RPGPVSSLLS---EPEIDHTSLKAAVDATVALLEKSASPVMLLGSKLRAANALAATETLA 233 Query: 224 GKIKAPIV------------HA-LRGKEHVEYDNPYDVGMTGLIGFSSGFHTMMNADTLV 270 K++ + HA RG E NP G+ L+ S D L+ Sbjct: 234 DKLQCAVTIMAAAKGFFPEDHAGFRGLYWGEVSNP---GVQELVETS---------DALL 281 Query: 271 LLGTQF-PYRAF----YPTDAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEE 325 + F Y +P +I + + ++ + TLRA L + E Sbjct: 282 CIAPVFNDYSTVGWSAWPKGPNVILAEPDRVTVDGRAYDGF--------TLRAFLQALAE 333 Query: 326 KADRKFLDKALEDYRDARKGLDDLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTV 385 KA + + + A E + + + I+ + + G Sbjct: 334 KAPAR----PASAQKSSVPTCSLTATSDEAGLTNDEIVRHINALLTSNTTLVAETGDSWF 389 Query: 386 WAARYLKMNGKRRLLGSFNHGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLS 445 A R G R L G + ++P A G +RQ V M GDG F + + Sbjct: 390 NAMRMTLPRGARVEL-EMQWGHIGWSVPSAFGNAMGSQDRQHVVMVGDGSFQLTAQEVAQ 448 Query: 446 VVQMKLPVKIVVFNNSVLGFV-AMEMKAGGYLTDGTELHDTNFARIAEACGI-----TGI 499 +V+ +LPV I + NN G+V + + G Y + + ++A + E G+ Sbjct: 449 MVRYELPVIIFLINNR--GYVIEIAIHDGPY----NYIKNWDYAGLMEVFNAGEGHGLGL 502 Query: 500 RVEKASEVDEALQRA-FSIDGPVLVDVVVAKEE 531 + E+ EA+ RA + GP L++ + + + Sbjct: 503 KATTPKELTEAIARAKANTRGPTLIECQIDRTD 535 >4COK-A nrPDB Length = 558 Score = 48.5 bits (114), Expect = 7e-06, Method: Compositional matrix adjust. Identities = 44/178 (24%), Positives = 77/178 (43%), Gaps = 16/178 (8%) Query: 362 LAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAMPQALGAQAT 421 +A+QI T + G A R +G R L G + ++P A G Sbjct: 366 MARQIGALLTPRTTLTAETGDSWFNAVRMKLPHGARVEL-EMQWGHIGWSVPAAFGNALA 424 Query: 422 EPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAMEMKAGGYLTDG-- 479 PERQ V M GDG F + + +++ LPV I + NN G+ M + DG Sbjct: 425 APERQHVLMVGDGSFQLTAQEVAQMIRHDLPVIIFLINNH--GYTIEVM-----IHDGPY 477 Query: 480 TELHDTNFARIAEACGI-----TGIRVEKASEVDEALQRA-FSIDGPVLVDVVVAKEE 531 + + ++A + E G+R E+ A+++A + +GP L++ + +++ Sbjct: 478 NNVKNWDYAGLMEVFNAGEGNGLGLRARTGGELAAAIEQARANRNGPTLIECTLDRDD 535 >1QPB-A nrPDB Length = 563 Score = 47.8 bits (112), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 95/503 (18%), Positives = 190/503 (37%), Gaps = 82/503 (16%) Query: 4 TVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQL 63 T+ Y+ + L+ V ++G+ GD L D + + + W +E AA+AA A++ Sbjct: 5 TLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYARI 64 Query: 64 SGELAVCAGSCGPGNLHLINGLFDCH--------RNHVPVLAIAAH--IPSSEIGSGYFQ 113 G ++ + G G L +NG+ + VP ++ A + +G+G F Sbjct: 65 KG-MSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGDFT 123 Query: 114 ETH--PQELFRECSHYCELVSSPEQI------------PQVLAIAMRKAVLNRGVSVVVL 159 H + + ++ ++P +I P L + LN ++ Sbjct: 124 VFHRMSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAKLLQT 183 Query: 160 PGDVALKPAPEGATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSGCA-----G 214 P D++LKP + E+E + + L++ + N ++ + C+ Sbjct: 184 PIDMSLKPNDAES--------------EKEVIDTILVLIKDAKNPVILADACCSRHDVKA 229 Query: 215 AHKELVEFAGKIKAPIVHALRGKEHVEYDNPYDVGM-TGLIGFSSGFHTMMNADTLVLLG 273 K+L++ + P GK ++ +P G+ G + + +AD ++ +G Sbjct: 230 ETKKLIDLT---QFPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVG 286 Query: 274 TQFPYRAFYPTDAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLD 333 A + + S +K + D A P V+ K L Sbjct: 287 ------------ALLSDFNTGSFSYSYKTKNIVEFHSDHMKIRNATFPGVQMKF---VLQ 331 Query: 334 KALEDYRDARKGLD----------DLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTP 383 K L DA KG + A P+ + +++ Q+ +F + + + GT Sbjct: 332 KLLTAIADAAKGYKPVAVPARTPANAAVPASTPLKQEWMWNQLGNFLQEGDVVIAETGTS 391 Query: 384 TVWAARYLKMNG----KRRLLGS--FNHGSMANAMPQALGAQATEPERQVVAMCGDGGFS 437 + N + L GS F G+ A A A+ +P+++V+ GDG Sbjct: 392 AFGINQTTFPNNTYGISQVLWGSIGFTTGATLGA---AFAAEEIDPKKRVILFIGDGSLQ 448 Query: 438 MLMGDFLSVVQMKLPVKIVVFNN 460 + + + ++++ L + V NN Sbjct: 449 LTVQEISTMIRWGLKPYLFVLNN 471 >5B47-B nrPDB Length = 304 Score = 34.7 bits (78), Expect = 0.12, Method: Compositional matrix adjust. Identities = 30/123 (24%), Positives = 55/123 (44%), Gaps = 11/123 (8%) Query: 415 ALGAQATEPERQVVAMCGDG-GFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAMEMKAG 473 A G + + P +V+ GDG G + MG F+ + + + + ++V NN V G + Sbjct: 72 ATGIKLSNPSLEVIVNVGDGDGLGIGMGHFVHLGRRNIDIAVLVHNNGVYGLTKGQASPT 131 Query: 474 GYLTDGTE-------LHDTNFARIAEACGITGIRVEKASEV---DEALQRAFSIDGPVLV 523 + + T+ + N +A A G T + A +V E +++A G LV Sbjct: 132 LHRGEKTKSLPKPNIMDAVNPLAVALAAGYTFVARGYAYDVMHLKELIKKAILHKGSALV 191 Query: 524 DVV 526 D++ Sbjct: 192 DIL 194 >2VHY-A nrPDB Length = 377 Score = 30.4 bits (67), Expect = 2.3, Method: Compositional matrix adjust. Identities = 30/98 (30%), Positives = 42/98 (42%), Gaps = 10/98 (10%) Query: 430 MCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAMEMKAGGYLTDGTELHDTNFAR 489 M GG +LMG V P +VV G+ A + G T + D N + Sbjct: 150 MRTQGGRGVLMGGVPGVE----PADVVVIGAGTAGYNAARIANGMGAT--VTVLDINIDK 203 Query: 490 I----AEACGITGIRVEKASEVDEALQRAFSIDGPVLV 523 + AE CG R A E++ A++RA + G VLV Sbjct: 204 LRQLDAEFCGRIHTRYSSAYELEGAVKRADLVIGAVLV 241 >4AAJ-A nrPDB Length = 228 Score = 30.0 bits (66), Expect = 3.2, Method: Compositional matrix adjust. Identities = 21/85 (24%), Positives = 40/85 (47%), Gaps = 6/85 (7%) Query: 173 TMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALM-CGSGCAGAHKELVEFAGKIKAPIV 231 M + P PEE+ R L+++ RY++++ L+ G+G H V K P++ Sbjct: 118 VMKAFRVPTISKNPEEDANRLLSEISRYNADMVLLDTGAGSGKLHDLRVSSLVARKIPVI 177 Query: 232 -----HALRGKEHVEYDNPYDVGMT 251 +A +E ++ PY V ++ Sbjct: 178 VAGGLNAENVEEVIKVVKPYGVDVS 202 >3EU9-A nrPDB Length = 240 Score = 29.3 bits (64), Expect = 4.3, Method: Compositional matrix adjust. Identities = 19/74 (25%), Positives = 34/74 (45%), Gaps = 14/74 (18%) Query: 143 IAMRKAVLNRGVSVVVLPGDVALKPAPEGATMHWYHAPQPVVTPEEEELRKLAQLLRYSS 202 I + K +++G V L GD+ P +HW + L + QL++Y + Sbjct: 55 IDLVKYYISKGAIVDQLGGDLNSTP------LHW--------ATRQGHLSMVVQLMKYGA 100 Query: 203 NIALMCGSGCAGAH 216 + +L+ G GC+ H Sbjct: 101 DPSLIDGEGCSCIH 114 >3LCG-A nrPDB Length = 319 Score = 29.3 bits (64), Expect = 5.3, Method: Compositional matrix adjust. Identities = 17/55 (30%), Positives = 29/55 (52%), Gaps = 4/55 (7%) Query: 116 HPQELFRECSHYCELVSSPEQIPQVL----AIAMRKAVLNRGVSVVVLPGDVALK 166 +P C HY ++ S + +P V+ A++ K L++ ++V LPG ALK Sbjct: 133 YPFSFEEHCDHYRAIIDSADGLPMVVYNIPALSGVKLTLDQINTLVTLPGVGALK 187 >6HMF-A nrPDB Length = 475 Score = 28.9 bits (63), Expect = 6.2, Method: Compositional matrix adjust. Identities = 19/45 (42%), Positives = 25/45 (55%), Gaps = 2/45 (4%) Query: 306 MALVGDIKSTLRALLPLVEEKAD--RKFLDKALEDYRDARKGLDD 348 + LV + T R L+ VE+K + FL K EDYR+A K L D Sbjct: 126 IGLVNSKRETNRGLIFEVEDKTGIVKVFLPKDSEDYREAFKVLPD 170 >6HMS-A nrPDB Length = 400 Score = 28.9 bits (63), Expect = 6.6, Method: Compositional matrix adjust. Identities = 19/45 (42%), Positives = 25/45 (55%), Gaps = 2/45 (4%) Query: 306 MALVGDIKSTLRALLPLVEEKAD--RKFLDKALEDYRDARKGLDD 348 + LV + T R L+ VE+K + FL K EDYR+A K L D Sbjct: 51 IGLVNSKRETNRGLIFEVEDKTGIVKVFLPKDSEDYREAFKVLPD 95 >2X7J-A nrPDB Length = 604 Score = 28.9 bits (63), Expect = 7.2, Method: Compositional matrix adjust. Identities = 41/194 (21%), Positives = 79/194 (40%), Gaps = 20/194 (10%) Query: 55 FAAG-AEAQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQ 113 FA G A+A+ L +C N + + + H + VP++ + A P G Q Sbjct: 84 FALGLAKAKQRPVLLICTSGTAAANFY--PAVVEAHYSRVPIIVLTADRPHELREVGAPQ 141 Query: 114 ETHPQELFRECSHYCELVSSPEQIPQVL----AIAMRKA-----------VLNRGVSVVV 158 + LF + + PE+ PQ+L +A R A +N + + Sbjct: 142 AINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQKRPMGPVHVNVPLREPL 201 Query: 159 LPGDVALKPAPEGATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSGCAGAHKE 218 +P D++ +P T + + E L +A++L + ++CG + A KE Sbjct: 202 MP-DLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAEAEKGMIVCGELHSDADKE 260 Query: 219 -LVEFAGKIKAPIV 231 ++ + ++ PI+ Sbjct: 261 NIIALSKALQYPIL 274 >4XFM-A nrPDB Length = 464 Score = 28.5 bits (62), Expect = 9.4, Method: Compositional matrix adjust. Identities = 35/141 (24%), Positives = 55/141 (39%), Gaps = 32/141 (22%) Query: 350 AKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGS---FNHG 406 A+ E + Q L + ISH+ + + V A L +G RR L + G Sbjct: 346 ARCRELGLSRQQLGETISHYLGE-------LTRSIVQALDSLAADGTRRRLPGGLYLSGG 398 Query: 407 SMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFV 466 +A A+ ALGA + + Q+ A C G+ + NS++G Sbjct: 399 DIAIAVATALGATGFQIKGQI-ASCVPWGYLL---------------------NSIVGMT 436 Query: 467 AMEMKAGGYLTDGTELHDTNF 487 + KAGG+ + T L F Sbjct: 437 PVMTKAGGFGNETTLLDVLRF 457 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: 3EYA-A nrPDB 635 0.0 1T9B-A nrPDB 517 e-147 6DEO-A nrPDB 513 e-146 5WJ1-A nrPDB 500 e-142 1V5E-A nrPDB 499 e-141 2EZ4-A nrPDB 496 e-140 5NPU-A nrPDB 486 e-137 4RJK-A nrPDB 469 e-132 2VBI-A nrPDB 465 e-131 2PAN-A nrPDB 461 e-130 5D6R-B nrPDB 458 e-129 5EUJ-A nrPDB 438 e-123 2JI6-A nrPDB 429 e-120 2VBF-A nrPDB 429 e-120 5AHK-A nrPDB 426 e-119 4ZP1-A nrPDB 417 e-117 1OVM-A nrPDB 417 e-117 2Q28-A nrPDB 417 e-117 2PGN-A nrPDB 416 e-116 4QQ8-A nrPDB 412 e-115 4COK-A nrPDB 408 e-114 6EFG-A nrPDB 385 e-107 1QPB-A nrPDB 380 e-106 1UPC-A nrPDB 363 e-101 2Q5O-A nrPDB 363 e-100 6A50-A nrPDB 360 e-100 4Q9D-A nrPDB 356 1e-98 4K9Q-A nrPDB 351 5e-97 Sequences not found previously or not previously below threshold: 3LQ1-A nrPDB 136 2e-32 2X7J-A nrPDB 131 6e-31 2JLA-A nrPDB 105 6e-23 5ESS-A nrPDB 91 1e-18 5B47-B nrPDB 50 3e-06 6N2O-B nrPDB 46 4e-05 3DVA-A nrPDB 45 8e-05 1YTL-A nrPDB 41 0.001 5B48-A nrPDB 39 0.005 3CF4-G nrPDB 39 0.009 1UM9-A nrPDB 37 0.016 3I9V-3 nrPDB 35 0.066 5B46-A nrPDB 35 0.11 4WBT-A nrPDB 34 0.18 5LUC-A nrPDB 34 0.20 1X7Z-A nrPDB 34 0.22 5B48-B nrPDB 33 0.29 3JC8-Ba nrPDB 33 0.29 6GCS-A nrPDB 32 0.51 2O1S-A nrPDB 32 0.52 3SFW-A nrPDB 32 0.55 1ESQ-A nrPDB 32 0.64 2R3S-A nrPDB 32 0.68 3QM3-A nrPDB 32 0.93 4W8I-A nrPDB 32 1.0 6CUM-A nrPDB 31 1.1 5GPN-Y nrPDB 31 1.1 1ULZ-A nrPDB 31 1.3 3B8A-X nrPDB 31 1.3 3JB9-S nrPDB 31 1.5 2YCL-A nrPDB 31 1.7 1M93-B nrPDB 30 2.0 1C8O-A nrPDB 30 2.0 2ZHG-A nrPDB 30 2.2 4MB2-A nrPDB 30 2.5 2EBS-A nrPDB 30 2.6 6GUA-A nrPDB 30 2.6 6CGR-k nrPDB 30 3.1 5U4N-A nrPDB 30 3.3 1P4S-A nrPDB 30 3.5 5MLK-A nrPDB 30 3.6 5JLR-A nrPDB 30 3.7 4P2C-A nrPDB 29 4.2 1S4Q-A nrPDB 29 4.5 4Z5Q-A nrPDB 29 4.7 2QVH-A nrPDB 29 5.5 2O1X-A nrPDB 29 6.4 >3EYA-A nrPDB Length = 549 Score = 635 bits (1638), Expect = 0.0, Method: Composition-based stats. Identities = 549/549 (100%), Positives = 549/549 (100%) Query: 1 MKQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAE 60 MKQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAE Sbjct: 1 MKQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAE 60 Query: 61 AQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQEL 120 AQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQEL Sbjct: 61 AQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQEL 120 Query: 121 FRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDVALKPAPEGATMHWYHAP 180 FRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDVALKPAPEGATMHWYHAP Sbjct: 121 FRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDVALKPAPEGATMHWYHAP 180 Query: 181 QPVVTPEEEELRKLAQLLRYSSNIALMCGSGCAGAHKELVEFAGKIKAPIVHALRGKEHV 240 QPVVTPEEEELRKLAQLLRYSSNIALMCGSGCAGAHKELVEFAGKIKAPIVHALRGKEHV Sbjct: 181 QPVVTPEEEELRKLAQLLRYSSNIALMCGSGCAGAHKELVEFAGKIKAPIVHALRGKEHV 240 Query: 241 EYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPYRAFYPTDAKIIQIDINPASIGA 300 EYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPYRAFYPTDAKIIQIDINPASIGA Sbjct: 241 EYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPYRAFYPTDAKIIQIDINPASIGA 300 Query: 301 HSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGLDDLAKPSEKAIHPQ 360 HSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGLDDLAKPSEKAIHPQ Sbjct: 301 HSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGLDDLAKPSEKAIHPQ 360 Query: 361 YLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAMPQALGAQA 420 YLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAMPQALGAQA Sbjct: 361 YLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAMPQALGAQA 420 Query: 421 TEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAMEMKAGGYLTDGT 480 TEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAMEMKAGGYLTDGT Sbjct: 421 TEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAMEMKAGGYLTDGT 480 Query: 481 ELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDVVVAKEELAIPPQIKL 540 ELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDVVVAKEELAIPPQIKL Sbjct: 481 ELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDVVVAKEELAIPPQIKL 540 Query: 541 EQAKGFSLY 549 EQAKGFSLY Sbjct: 541 EQAKGFSLY 549 >1T9B-A nrPDB Length = 677 Score = 517 bits (1331), Expect = e-147, Method: Composition-based stats. Identities = 139/563 (24%), Positives = 251/563 (44%), Gaps = 33/563 (5%) Query: 4 TVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQL 63 T + + V ++G G ++ + D+++ ++ +HE+ A A A+ Sbjct: 83 TGGQIFNEMMSRQNVDTVFGYPGGAILPVYDAIHNSDKFNFVLPKHEQGAGHMAEGYARA 142 Query: 64 SGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFRE 123 SG+ V + GPG +++ + D + +P++ +P+S IG+ FQE + R Sbjct: 143 SGKPGVVLVTSGPGATNVVTPMADAFADGIPMVVFTGQVPTSAIGTDAFQEADVVGISRS 202 Query: 124 CSHYCELVSSPEQIPQVLAIAMRKAVLNR-GVSVVVLPGDVAL----KPAPEGATMHWYH 178 C+ + +V S E++P + A A R G +V LP DV P P T+ Sbjct: 203 CTKWNVMVKSVEELPLRINEAFEIATSGRPGPVLVDLPKDVTAAILRNPIPTKTTLPSNA 262 Query: 179 APQPVVTPEEE----ELRKLAQLLRYSSNIALMCGSGC---AGAHKELVEFAGKIKAPIV 231 Q ++E + K A L+ + L G+G A + L E + + + P+ Sbjct: 263 LNQLTSRAQDEFVMQSINKAADLINLAKKPVLYVGAGILNHADGPRLLKELSDRAQIPVT 322 Query: 232 HALRGKEHVEYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPYRAFYP-------- 283 L+G + ++P + M G+ G ++ + NAD ++ +G +F R Sbjct: 323 TTLQGLGSFDQEDPKSLDMLGMHGCATANLAVQNADLIIAVGARFDDRVTGNISKFAPEA 382 Query: 284 ------TDAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALE 337 II +++P +I + +A+ GD + L ++ + +R + Sbjct: 383 RRAAAEGRGGIIHFEVSPKNINKVVQTQIAVEGDATTNLGKMMSKIFPVKERSEWFAQIN 442 Query: 338 DYRDARKGLDDLAKPSEKAIHPQYLAQQISHFAAD---DAIFTCDVGTPTVWAARYLKMN 394 ++ P I PQ + +++S A D I T VG +WAA++ Sbjct: 443 KWKKEYPYAYMEETP-GSKIKPQTVIKKLSKVANDTGRHVIVTTGVGQHQMWAAQHWTWR 501 Query: 395 GKRRLLGSFNHGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVK 454 + S G+M +P A+GAQ +PE V+ + GD F+M + + S VQ PVK Sbjct: 502 NPHTFITSGGLGTMGYGLPAAIGAQVAKPESLVIDIDGDASFNMTLTELSSAVQAGTPVK 561 Query: 455 IVVFNNSVLGFVAMEMKAGGYLTDGTELH--DTNFARIAEACGITGIRVEKASEVDEALQ 512 I++ NN G V + ++ Y + H + +F ++AEA G+ G+RV+K E+D L+ Sbjct: 562 ILILNNEEQGMVT-QWQSLFYEHRYSHTHQLNPDFIKLAEAMGLKGLRVKKQEELDAKLK 620 Query: 513 RAFSIDGPVLVDVVVAKEELAIP 535 S GPVL++V V K+ +P Sbjct: 621 EFVSTKGPVLLEVEVDKKVPVLP 643 >6DEO-A nrPDB Length = 682 Score = 513 bits (1322), Expect = e-146, Method: Composition-based stats. Identities = 139/563 (24%), Positives = 255/563 (45%), Gaps = 33/563 (5%) Query: 4 TVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQL 63 T + + V ++G G ++ + D++ +++ RHE+ A A A+ Sbjct: 88 TGGEIFHEMMLRHKVDTVFGYAGGAILPVFDAIYNSDKFKFVLPRHEQGAGHMAEGYARA 147 Query: 64 SGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFRE 123 SG+ V + GPG ++I + D + VP++ + +P++ IG+ FQE + R Sbjct: 148 SGKPGVVLVTSGPGATNVITPMADALMDGVPLVVFSGQVPTTAIGTDAFQEADIVGISRS 207 Query: 124 CSHYCELVSSPEQIPQVLAIAMRKAVLNR-GVSVVVLPGDVAL----KPAPEGATMHWYH 178 C+ + +V + ++P+ + A A R G +V LP DV + P T+ Sbjct: 208 CTKWNVMVKNVAELPRRINEAFEIATTGRPGPVLVDLPKDVTASILRESIPINTTLPSNA 267 Query: 179 APQ----PVVTPEEEELRKLAQLLRYSSNIALMCGSGCAGAH---KELVEFAGKIKAPIV 231 Q V E +++ A +L + + G+G K L E A K P+ Sbjct: 268 LSQITKKAVSEFTSEAIKRAANILNKAKKPIIYAGAGILNNEQGPKLLKELADKANIPVT 327 Query: 232 HALRGKEHVEYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPYRAF-----YPTDA 286 L+G + +P + M G+ G ++ + NAD ++ LG +F R + +A Sbjct: 328 TTLQGLGAFDQRDPKSLDMLGMHGSAAANTAIQNADCIIALGARFDDRVTGNISKFAPEA 387 Query: 287 K---------IIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALE 337 K I+ +I+P +I + A+ GD+ + L++ +PLV+ +R + Sbjct: 388 KLAASEGRGGILHFEISPKNINKVVEATEAIEGDVTANLQSFIPLVDSIENRPEWFNKIN 447 Query: 338 DYRDARKGLDDLAKPSEKAIHPQYLAQQISHFAA---DDAIFTCDVGTPTVWAARYLKMN 394 +++ L P I PQ L ++IS A + I T VG +WAA++ Sbjct: 448 EWKKKYPYSYQLETP-GSLIKPQTLIKEISDQAQTYNKEVIVTTGVGQHQMWAAQHFTWT 506 Query: 395 GKRRLLGSFNHGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVK 454 R ++ S G+M +P A+GAQ +P+ V+ + GD F+M + + S VQ P+K Sbjct: 507 QPRTMITSGGLGTMGYGLPAAIGAQVAKPDAIVIDIDGDASFNMTLTELSSAVQAGAPIK 566 Query: 455 IVVFNNSVLGFVAMEMKAGGYLTDGTELH--DTNFARIAEACGITGIRVEKASEVDEALQ 512 + V NN G V + ++ Y + H + +F ++AE+ + GIR+ E+ ++ Sbjct: 567 VCVLNNEEQGMVT-QWQSLFYEHRYSHTHQSNPDFMKLAESMNVKGIRITNQQELKSGVK 625 Query: 513 RAFSIDGPVLVDVVVAKEELAIP 535 PVL++V+V K+ +P Sbjct: 626 EFLDATEPVLLEVIVEKKVPVLP 648 >5WJ1-A nrPDB Length = 590 Score = 500 bits (1288), Expect = e-142, Method: Composition-based stats. Identities = 156/552 (28%), Positives = 259/552 (46%), Gaps = 22/552 (3%) Query: 5 VAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQLS 64 A + + LE GV+ ++ G + + +L R +I + RHE+ FAA A+ S Sbjct: 14 GADILVEALERQGVETVFAYPGGASMEIHQALTRSSSIRNVLPRHEQGGVFAAEGYARSS 73 Query: 65 GELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFREC 124 G+ +C + GPG +L++GL D + VP++AI +P IG+ FQET E+ R Sbjct: 74 GKPGICIATSGPGATNLVSGLADALLDSVPLVAITGQVPRRMIGTDAFQETPIVEVTRSI 133 Query: 125 SHYCELVSSPEQIPQVLAIAMRKAVLNR-GVSVVVLPGDVALK---PAPEGATMHWYHAP 180 + + LV E IP+++ A A R G +V +P D+ + P E A + Sbjct: 134 TKHNYLVMDVEDIPRIIEEAFFLATSGRPGPVLVDVPKDIQQQLAIPNWEQAMRLPGYMS 193 Query: 181 QPVVTPEEEELRKLAQLLRYSSNIALMCGSGCAGAHKELVEFAGKIKAPIVHALRGKEHV 240 + PE+ L ++ +L+ S L G GC + EL F P+ L G Sbjct: 194 RMPKPPEDSHLEQIVRLISESKKPVLYVGGGCLNSSDELGRFVELTGIPVASTLMGLGSY 253 Query: 241 EYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPYRAF-----YPTDAKIIQIDINP 295 D+ + M G+ G + + ++D L+ G +F R + + AKI+ IDI+ Sbjct: 254 PCDDELSLHMLGMHGTVYANYAVEHSDLLLAFGVRFDDRVTGKLEAFASRAKIVHIDIDS 313 Query: 296 ASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKAL-EDYRDARKGLDDLA-KPS 353 A IG + +++ GD+K L+ + ++E +A+ LD + + + +K L+ K Sbjct: 314 AEIGKNKTPHVSVCGDVKLALQGMNKVLENRAEELKLDFGVWRNELNVQKQKFPLSFKTF 373 Query: 354 EKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAMP 413 +AI PQY + + AI + VG +WAA++ R+ L S G+M +P Sbjct: 374 GEAIPPQYAIKVLDELTDGKAIISTGVGQHQMWAAQFYNYKKPRQWLSSGGLGAMGFGLP 433 Query: 414 QALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAMEMKAG 473 A+GA P+ VV + GDG F M + + ++ LPVK+++ NN LG V M+ + Sbjct: 434 AAIGASVANPDAIVVDIDGDGSFIMNVQELATIRVENLPVKVLLLNNQHLGMV-MQWEDR 492 Query: 474 GYLTDGTELHDTN----------FARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLV 523 Y + + A ACGI RV K +++ EA+Q GP L+ Sbjct: 493 FYKANRAHTFLGDPAQEDEIFPNMLLFAAACGIPAARVTKKADLREAIQTMLDTPGPYLL 552 Query: 524 DVVVAKEELAIP 535 DV+ +E +P Sbjct: 553 DVICPHQEHVLP 564 >1V5E-A nrPDB Length = 590 Score = 499 bits (1284), Expect = e-141, Method: Composition-based stats. Identities = 162/553 (29%), Positives = 274/553 (49%), Gaps = 15/553 (2%) Query: 2 KQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSL-NRMGTIEWMSTRHEEVAAFAAGAE 60 K + + K LES G I+G+ +L+ L D++ ++++ +HEEV A AA + Sbjct: 3 KINIGLAVMKILESWGADTIYGIPSGTLSSLMDAMGEEENNVKFLQVKHEEVGAMAAVMQ 62 Query: 61 AQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQEL 120 ++ G L V GS GPG HLINGL+D +++PV+AI P E+ FQE + + Sbjct: 63 SKFGGNLGVTVGSGGPGASHLINGLYDAAMDNIPVVAILGSRPQRELNMDAFQELNQNPM 122 Query: 121 FRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDVALKPAPEGATMHWYHAP 180 + + Y V+ EQ+P+++ A R A+ RGV+V+ +PGD A E WY + Sbjct: 123 YDHIAVYNRRVAYAEQLPKLVDEAARMAIAKRGVAVLEVPGDFAK---VEIDNDQWYSSA 179 Query: 181 Q-----PVVTPEEEELRKLAQLLRYSSNIALMCGSGCAGAHKELVEFAGKIKAPIVHALR 235 + P +++ +LL S + G G G + E A KIKAP++ + Sbjct: 180 NSLRKYAPIAPAAQDIDAAVELLNNSKRPVIYAGIGTMGHGPAVQELARKIKAPVITTGK 239 Query: 236 GKEHVEYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPYR---AFYPTDAKIIQID 292 E E+D G T +G+ T++ ADT++ G+ FP+ + IQID Sbjct: 240 NFETFEWDFEALTGSTYRVGWKPANETILEADTVLFAGSNFPFSEVEGTFRNVDNFIQID 299 Query: 293 INPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGLDDLAKP 352 I+PA +G D+A++GD + +L V+ + + L++ + R+ ++ L Sbjct: 300 IDPAMLGKRHHADVAILGDAALAIDEILNKVDAVEESAWWTANLKNIANWREYINMLETK 359 Query: 353 SEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAM 412 E + + I++ A +DAI++ DVG T + R+L M K S +M A+ Sbjct: 360 EEGDLQFYQVYNAINNHADEDAIYSIDVGNSTQTSIRHLHMTPKNMWRTSPLFATMGIAI 419 Query: 413 PQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAMEMKA 472 P LGA+ T P+RQV + GDG FSM D ++ V+ +PV VVF+N+ F+ + + Sbjct: 420 PGGLGAKNTYPDRQVWNIIGDGAFSMTYPDVVTNVRYNMPVINVVFSNTEYAFIKNKYED 479 Query: 473 GGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDG---PVLVDVVVAK 529 G + D ++A+IAEA G G V + ++D + A + + V++D + + Sbjct: 480 TNKNLFGVDFTDVDYAKIAEAQGAKGFTVSRIEDMDRVMAEAVAANKAGHTVVIDCKITQ 539 Query: 530 EELAIPPQIKLEQ 542 + +KL+ Sbjct: 540 DRPIPVETLKLDS 552 >2EZ4-A nrPDB Length = 603 Score = 496 bits (1276), Expect = e-140, Method: Composition-based stats. Identities = 168/561 (29%), Positives = 280/561 (49%), Gaps = 21/561 (3%) Query: 1 MKQT------VAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLN-RMGTIEWMSTRHEEVA 53 MKQT A + K LE+ GV ++G+ G S+N + D+L+ I ++ RHEEV Sbjct: 3 MKQTKQTNILAGAAVIKVLEAWGVDHLYGIPGGSINSIMDALSAERDRIHYIQVRHEEVG 62 Query: 54 AFAAGAEAQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQ 113 A AA A+A+L+G++ VC GS GPG HL+NGL+D +HVPVLA+ ++ + FQ Sbjct: 63 AMAAAADAKLTGKIGVCFGSAGPGGTHLMNGLYDAREDHVPVLALIGQFGTTGMNMDTFQ 122 Query: 114 ETHPQELFRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDVALKPAPEGAT 173 E + ++ + + Y + +P V+ A+R+A ++GV+VV +P D+ + P Sbjct: 123 EMNENPIYADVADYNVTAVNAATLPHVIDEAIRRAYAHQGVAVVQIPVDLPWQQIPAED- 181 Query: 174 MHWYHAPQPVVTP-----EEEELRKLAQLLRYSSNIALMCGSGCAGAHKELVEFAGKIKA 228 WY + TP + + + +L Q L + + G G A KEL + + +K Sbjct: 182 --WYASANSYQTPLLPEPDVQAVTRLTQTLLAAERPLIYYGIGARKAGKELEQLSKTLKI 239 Query: 229 PIVHALRGKEHVEYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPY---RAFYPTD 285 P++ K V P +G + + AD ++ +G +P+ + Sbjct: 240 PLMSTYPAKGIVADRYPAYLGSANRVAQKPANEALAQADVVLFVGNNYPFAEVSKAFKNT 299 Query: 286 AKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKG 345 +QIDI+PA +G K D+A++ D + TL A+L V E+ + L + ++ R Sbjct: 300 RYFLQIDIDPAKLGKRHKTDIAVLADAQKTLAAILAQVSERESTPWWQANLANVKNWRAY 359 Query: 346 LDDLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNH 405 L L E + + + ++ A DAI++ DVG + A R+LK+ R + S Sbjct: 360 LASLEDKQEGPLQAYQVLRAVNKIAEPDAIYSIDVGDINLNANRHLKLTPSNRHITSNLF 419 Query: 406 GSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGF 465 +M +P A+ A+ PERQV + GDGG SM M D + VQ LPV VVF N G+ Sbjct: 420 ATMGVGIPGAIAAKLNYPERQVFNLAGDGGASMTMQDLATQVQYHLPVINVVFTNCQYGW 479 Query: 466 VAMEMKAGGYLTD-GTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSI--DGPVL 522 + E + G E +D +F++IA+ + RV K ++ + ++A +I PVL Sbjct: 480 IKDEQEDTNQNDFIGVEFNDIDFSKIADGVHMQAFRVNKIEQLPDVFEQAKAIAQHEPVL 539 Query: 523 VDVVVAKEELAIPPQIKLEQA 543 +D V+ + +++L+ A Sbjct: 540 IDAVITGDRPLPAEKLRLDSA 560 >5NPU-A nrPDB Length = 563 Score = 486 bits (1250), Expect = e-137, Method: Composition-based stats. Identities = 115/557 (20%), Positives = 214/557 (38%), Gaps = 37/557 (6%) Query: 1 MKQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAE 60 M TV Y+A L G+K + V GD L D L + +E + +E F+A Sbjct: 1 MTYTVGHYLATRLAQIGLKHHFAVAGDYNLVLLDQLLKNKDLEQVYCCNELNCGFSAEGY 60 Query: 61 AQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQET----- 115 A+ +G + + G L N + + ++PV+ I+ +++ GSG+ Sbjct: 61 ARANG-VGAAVVTFSVGALSAFNAIGGAYAENLPVILISGAPNTNDHGSGHILHHTIGTT 119 Query: 116 ---HPQELFRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDVALKP-APEG 171 + E+ ++ + ++ E P ++ A+R A+ + + + + +VA +P A G Sbjct: 120 DYGYQLEMAKQITCAAVSITHAEDAPALIDHAIRTALREKKPAYIEIACNVAAQPCARPG 179 Query: 172 ATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSG--CAGAHKELVEFAGKIKAP 229 + P + + + L+ G AGA + +VE A + Sbjct: 180 PVSALLNEPTSDEETLKAAVEAALDFIEKREKPVLLVGGKLRAAGAEEAVVELADALGCA 239 Query: 230 IVHALRGKEHVEYDNPYDVGMT-GLIGFSSGFHTMMNADTLVLLGTQFPYR-----AFYP 283 + K D+P VG G + + AD ++ LG F +P Sbjct: 240 VATMAAAKSFFPEDHPGYVGTYWGEVSSPGVEEIVDWADGIICLGPVFNDYSTVGWTAWP 299 Query: 284 TDAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDAR 343 ++ +D + ++G + L K L AL V +K KA Sbjct: 300 KGENVVLVDPHHITVGGEEFTGIHL----KDFLTALTERVPKKDATLDQFKAR---VGKP 352 Query: 344 KGLDDLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSF 403 A + L +QI + + G A R +G R L Sbjct: 353 AAEKVPAADPNAPLTRAELCRQIQGLLNPNTTLIAETGDSWFNAMRMKLPHGARVEL-EM 411 Query: 404 NHGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVL 463 G + ++P G EPER+ V M GDG F + + +V+ KLP+ I + NN Sbjct: 412 QWGHIGWSVPATFGYAVAEPERRNVLMVGDGSFQLTAQEVAQMVRRKLPIIIFLINNRGY 471 Query: 464 GFVAMEMKAGGYLTDGTELHDTNFARIAEACGIT-----GIRVEKASEVDEALQRAFSID 518 + +++ G Y + + ++A + E G++ E+ EA+++A + Sbjct: 472 T-IEVKIHDGPY----NNIKNWDYAGLMEVFNAEDGKGLGLKATTGGELAEAIKKALAHR 526 Query: 519 -GPVLVDVVVAKEELAI 534 GP L++ V+ +++ Sbjct: 527 EGPTLIECVIDRDDCTP 543 >4RJK-A nrPDB Length = 571 Score = 469 bits (1208), Expect = e-132, Method: Composition-based stats. Identities = 132/542 (24%), Positives = 241/542 (44%), Gaps = 12/542 (2%) Query: 1 MKQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAE 60 +K A + L GV ++G+ G ++ + D+L G E + RHE+ AAF A A Sbjct: 13 VKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVFDALQDKGP-EIIVARHEQNAAFMAQAV 71 Query: 61 AQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQEL 120 +L+G+ V + GPG +L GL + PV+A+A ++ ++ Q L Sbjct: 72 GRLTGKPGVVLVTSGPGASNLATGLLTANTEGDPVVALAGNVIRADRLKRTHQSLDNAAL 131 Query: 121 FRECSHYCELVSSPEQIPQVLAIAMRKAVLNR-GVSVVVLPGDVALKPAPEGATMHWYHA 179 F+ + Y V + IP+ + A R A + G + V P DV + + A Sbjct: 132 FQPITKYSVEVQDVKNIPEAVTNAFRIASAGQAGAAFVSFPQDV-VNEVTNTKNVRAVAA 190 Query: 180 PQPVVTPEEEELRKLAQLLRYSSNIALMCG--SGCAGAHKELVEFAGKIKAPIVHALRGK 237 P+ ++ +A+ ++ + ++ G G A K + + K++ P V + Sbjct: 191 PKLGPAADDAISAAIAK-IQTAKLPVVLVGMKGGRPEAIKAVRKLLKKVQLPFVETYQAA 249 Query: 238 EHVEYDNP-YDVGMTGLIGFSSGFHTMMNADTLVLLGTQ---FPYRAF-YPTDAKIIQID 292 + D G GL G + AD ++ +G + + + D II +D Sbjct: 250 GTLSRDLEDQYFGRIGLFRNQPGDLLLEQADVVLTIGYDPIEYDPKFWNINGDRTIIHLD 309 Query: 293 INPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRD-ARKGLDDLAK 351 A I + D+ L+GDI ST+ + + + K L D + +G A Sbjct: 310 EIIADIDHAYQPDLELIGDIPSTINHIEHDAVKVEFAEREQKILSDLKQYMHEGEQVPAD 369 Query: 352 PSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANA 411 HP + +++ + D TCD+G+ +W +RY + L+ S ++ A Sbjct: 370 WKSDRAHPLEIVKELRNAVDDHVTVTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVA 429 Query: 412 MPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAMEMK 471 +P A+GA +P +VV++ GDGGF + + V++K P+ +V+N+S VA + Sbjct: 430 LPWAIGASLVKPGEKVVSVSGDGGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQL 489 Query: 472 AGGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDVVVAKEE 531 T + + + + AE+ G TG+RVE ++ + L++ + +GPV++DV V + Sbjct: 490 KKYNRTSAVDFGNIDIVKYAESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSD 549 Query: 532 LA 533 Sbjct: 550 NI 551 Score = 34.3 bits (77), Expect = 0.16, Method: Composition-based stats. Identities = 19/126 (15%), Positives = 36/126 (28%), Gaps = 18/126 (14%) Query: 66 ELA--VCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEI------------GSGY 111 + V + S G L L R P++ I + + ++ + Sbjct: 440 KPGEKVVSVSGDGGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVD 499 Query: 112 FQETHPQELFRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDVALKPAPEG 171 F + V SP+Q+ VL M G ++ +P D + Sbjct: 500 FGNIDIVKYAESFGATGLRVESPDQLADVLRQGMNA----EGPVIIDVPVDYSDNINLAS 555 Query: 172 ATMHWY 177 + Sbjct: 556 DKLPKE 561 >2VBI-A nrPDB Length = 566 Score = 465 bits (1196), Expect = e-131, Method: Composition-based stats. Identities = 108/554 (19%), Positives = 210/554 (37%), Gaps = 42/554 (7%) Query: 1 MKQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAE 60 M TV Y+A+ L G+K + V GD L D L ++ + +E F+A Sbjct: 1 MTYTVGMYLAERLVQIGLKHHFAVAGDYNLVLLDQLLLNKDMKQIYCCNELNCGFSAEGY 60 Query: 61 AQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYF-------- 112 A+ +G A + G + +N L + ++PV+ I+ S++ G+G+ Sbjct: 61 ARSNGAAAAV-VTFSVGAISAMNALGGAYAENLPVILISGAPNSNDQGTGHILHHTIGKT 119 Query: 113 QETHPQELFRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDVALKP-APEG 171 ++ E+ R+ + E ++ P + +R A+ R + + + ++A +P G Sbjct: 120 DYSYQLEMARQVTCAAESITDAHSAPAKIDHVIRTALRERKPAYLDIACNIASEPCVRPG 179 Query: 172 ATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSG--CAGAHKELVEFAGKIKAP 229 P+ T + + LL S++ ++ GS A A A K++ Sbjct: 180 PVSSLLSEPEIDHTSLKAAVDATVALLEKSASPVMLLGSKLRAANALAATETLADKLQCA 239 Query: 230 IVHALRGKEHVEYDNPYDVGMT-GLIGFSSGFHTMMNADTLVLLGTQFPYRAF-----YP 283 + K D+ G+ G + + +D L+ + F + +P Sbjct: 240 VTIMAAAKGFFPEDHAGFRGLYWGEVSNPGVQELVETSDALLCIAPVFNDYSTVGWSAWP 299 Query: 284 TDAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDAR 343 +I + + ++ + TLRA L + EKA + + + Sbjct: 300 KGPNVILAEPDRVTVDGRAYDGF--------TLRAFLQALAEKAPAR----PASAQKSSV 347 Query: 344 KGLDDLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSF 403 A E + + + I+ + + G A R G R L Sbjct: 348 PTCSLTATSDEAGLTNDEIVRHINALLTSNTTLVAETGDSWFNAMRMTLPRGARVEL-EM 406 Query: 404 NHGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVL 463 G + ++P A G +RQ V M GDG F + + +V+ +LPV I + NN Sbjct: 407 QWGHIGWSVPSAFGNAMGSQDRQHVVMVGDGSFQLTAQEVAQMVRYELPVIIFLINNRGY 466 Query: 464 GFVAMEMKAGGYLTDGTELHDTNFARIAEACGI-----TGIRVEKASEVDEALQRA-FSI 517 + + + G Y + + ++A + E G++ E+ EA+ RA + Sbjct: 467 -VIEIAIHDGPY----NYIKNWDYAGLMEVFNAGEGHGLGLKATTPKELTEAIARAKANT 521 Query: 518 DGPVLVDVVVAKEE 531 GP L++ + + + Sbjct: 522 RGPTLIECQIDRTD 535 >2PAN-A nrPDB Length = 616 Score = 461 bits (1186), Expect = e-130, Method: Composition-based stats. Identities = 135/558 (24%), Positives = 233/558 (41%), Gaps = 33/558 (5%) Query: 2 KQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEA 61 K LE G+ +GV G ++N ++ + G I + RH E A+ A Sbjct: 26 KMRAVDAAMYVLEKEGITTAFGVPGAAINPFYSAMRKHGGIRHILARHVEGASHMAEGYT 85 Query: 62 QLS-GELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQEL 120 + + G + VC G+ GP +I L+ + +P+L I P + + FQ + + Sbjct: 86 RATAGNIGVCLGTSGPAGTDMITALYSASADSIPILCITGQAPRARLHKEDFQAVDIEAI 145 Query: 121 FRECSHYCELVSSPEQIPQVLAIAMRKAVLNR-GVSVVVLPGDVALKPAPEGATMHWYHA 179 + S V +P+VL A R G +V LP DV + M+ Sbjct: 146 AKPVSKMAVTVREAALVPRVLQQAFHLMRSGRPGPVLVDLPFDVQVAEIEFDPDMY---E 202 Query: 180 PQPVVTPEEE--ELRKLAQLLRYSSNIALMCGSGC--AGAHKELVEFAGKIKAPIVHALR 235 P PV P ++ K ++L + ++ G G A A L +FA P++ L Sbjct: 203 PLPVYKPAASRMQIEKAVEMLIQAERPVIVAGGGVINADAAALLQQFAELTSVPVIPTLM 262 Query: 236 GKEHVEYDNPYDVGMTGL-IGFSSGFHTMMNADTLVLLGTQFPYRAF-----YPTDAKII 289 G + D+ GM GL G T++ +D + +G +F R Y KI+ Sbjct: 263 GWGCIPDDHELMAGMVGLQTAHRYGNATLLASDMVFGIGNRFANRHTGSVEKYTEGRKIV 322 Query: 290 QIDINPASIGAHSKVDMALVGDIKSTLRALLPLVE--EKADRKFLDK-ALEDYRDARKGL 346 IDI P IG D+ +V D K+ L L+ + + +KA R K + D + ++ L Sbjct: 323 HIDIEPTQIGRVLCPDLGIVSDAKAALTLLVEVAQEMQKAGRLPCRKEWVADCQQRKRTL 382 Query: 347 DDLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHG 406 + PQ + ++++ D + +G + AA+ L + R + G Sbjct: 383 LRKTHFDNVPVKPQRVYEEMNKAFGRDVCYVTTIGLSQIAAAQMLHVFKDRHWINCGQAG 442 Query: 407 SMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFV 466 + +P ALG A +P+R VVA+ GD F L+ + Q +P V+ NN+ LG + Sbjct: 443 PLGWTIPAALGVCAADPKRNVVAISGDFDFQFLIEELAVGAQFNIPYIHVLVNNAYLGLI 502 Query: 467 AMEMKA-----------GGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAF 515 +A + + + ++AE G IRV K ++ A ++A Sbjct: 503 RQSQRAFDMDYCVQLAFENINSSEVNGYGVDHVKVAEGLGCKAIRVFKPEDIAPAFEQAK 562 Query: 516 SIDG----PVLVDVVVAK 529 ++ PV+V+V++ + Sbjct: 563 ALMAQYRVPVVVEVILER 580 >5D6R-B nrPDB Length = 579 Score = 458 bits (1177), Expect = e-129, Method: Composition-based stats. Identities = 144/548 (26%), Positives = 254/548 (46%), Gaps = 13/548 (2%) Query: 5 VAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQLS 64 A + LE+ GV++++G+ G ++ + DSL I + RHE AAF A A +++ Sbjct: 33 GADLVVSQLEAQGVRQVFGIPGAKIDKVFDSLLDSS-IRIIPVRHEANAAFMAAAVGRIT 91 Query: 65 GELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFREC 124 G+ V + GPG +LI G+ + PV+A+ + ++ Q +F Sbjct: 92 GKAGVALVTSGPGCSNLITGMATANSEGDPVVALGGAVKRADKAKQVHQSMDTVAMFSPV 151 Query: 125 SHYCELVSSPEQIPQVLAIAMRKAVLNR-GVSVVVLPGDVALKPAPEGATMHWYHAPQPV 183 + Y V++P+ + +V++ A R A R G + V LP DV P G + APQ Sbjct: 152 TKYAIEVTAPDALAEVVSNAFRAAEQGRPGSAFVSLPQDVVDGPV-SGKVLPASGAPQMG 210 Query: 184 VTPEEEELRKLAQLLRYSSNIALMCG--SGCAGAHKELVEFAGKIKAPIVHALRGKEHVE 241 P++ + ++A+L+ + N + G + K L P+ + V Sbjct: 211 AAPDD-AIDQVAKLIAQAKNPIFLLGLMASQPENSKALRRLLETSHIPVTSTYQAAGAVN 269 Query: 242 YDN-PYDVGMTGLIGFSSGFHTMMNADTLVLLGT---QFPYRAFYPTDAKIIQIDINPAS 297 DN G GL +G + AD ++ +G ++ + +A ++ ID+ PA Sbjct: 270 QDNFSRFAGRVGLFNNQAGDRLLQLADLVICIGYSPVEYEPAMWNSGNATLVHIDVLPAY 329 Query: 298 IGAHSKVDMALVGDIKSTLRALLPLVEEK-ADRKFLDKALEDYRDARKGLDDL-AKPSEK 355 + D+ LVGDI TL L ++ + + L D + R+ LD A+ ++ Sbjct: 330 EERNYTPDVELVGDIAGTLNKLAQNIDHRLVLSPQAAEILRDRQHQRELLDRRGAQLNQF 389 Query: 356 AIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAMPQA 415 A+HP + + + D T D+G+ +W ARYL R+++ S +M A+P A Sbjct: 390 ALHPLRIVRAMQDIVNSDVTLTVDMGSFHIWIARYLYSFRARQVMISNGQQTMGVALPWA 449 Query: 416 LGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAMEMKAGGY 475 +GA PER+VV++ GDGGF + + V++K V +++ ++ VA++ + Sbjct: 450 IGAWLVNPERKVVSVSGDGGFLQSSMELETAVRLKANVLHLIWVDNGYNMVAIQEEKKYQ 509 Query: 476 LTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDVVVA-KEELAI 534 G E +F AE+ G G VE A ++ L+ A +DGP +V + V ++ + Sbjct: 510 RLSGVEFGPMDFKAYAESFGAKGFAVESAEALEPTLRAAMDVDGPAVVAIPVDYRDNPLL 569 Query: 535 PPQIKLEQ 542 Q+ L Q Sbjct: 570 MGQLHLSQ 577 >5EUJ-A nrPDB Length = 573 Score = 438 bits (1127), Expect = e-123, Method: Composition-based stats. Identities = 106/555 (19%), Positives = 218/555 (39%), Gaps = 48/555 (8%) Query: 3 QTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQ 62 TV Y+A+ L G+K + V GD L D L +E + +E F+A A+ Sbjct: 2 YTVGMYLAERLAQIGLKHHFAVAGDYNLVLLDQLLLNKDMEQVYCCNELNCGFSAEGYAR 61 Query: 63 LSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYF--------QE 114 A + G + +N + + ++PV+ I+ +++ G+G+ Sbjct: 62 AR-GAAAAIVTFSVGAISAMNAIGGAYAENLPVILISGSPNTNDYGTGHILHHTIGTTDY 120 Query: 115 THPQELFRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDV----ALKPAPE 170 + E+ + + E + S E+ P + +R A+ R + + + +V ++P P Sbjct: 121 NYQLEMVKHVTCAAESIVSAEEAPAKIDHVIRTALRERKPAYLEIACNVAGAECVRPGPI 180 Query: 171 GATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSGC--AGAHKELVEFAGKIKA 228 + + Q VT + + L+ N+ ++ GS A A K+ V A ++ Sbjct: 181 NSLLRELEVDQTSVTAA---VDAAVEWLQDRQNVVMLVGSKLRAAAAEKQAVALADRLGC 237 Query: 229 PIVHALRGKEHVEYDNPYDVGMT-GLIGFSSGFHTMMNADTLVLLGTQFPYRAF-----Y 282 + K D+P G+ G + + NAD ++ L F A + Sbjct: 238 AVTIMAAAKGFFPEDHPNFRGLYWGEVSSEGAQELVENADAILCLAPVFNDYATVGWNSW 297 Query: 283 PTDAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDA 342 P ++ +D + + S ++ L + EKA + + + Sbjct: 298 PKGDNVMVMDTDRVTFAGQSFEGLS--------LSTFAAALAEKAPSR--PATTQGTQAP 347 Query: 343 RKGLDDLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGS 402 G++ + + +QI D T + G A+R + G R+ Sbjct: 348 VLGIEAAE--PNAPLTNDEMTRQIQSLITSDTTLTAETGDSWFNASRM-PIPGGARVELE 404 Query: 403 FNHGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSV 462 G + ++P A G PER+ + M GDG F + + +++ ++PV I + NN Sbjct: 405 MQWGHIGWSVPSAFGNAVGSPERRHIMMVGDGSFQLTAQEVAQMIRYEIPVIIFLINNRG 464 Query: 463 LGFVAMEMKAGGYLTDGTELHDTNFARIAEACG-----ITGIRVEKASEVDEALQRAFS- 516 + + + G Y + + N+A + + G++ +E++ A+++A Sbjct: 465 Y-VIEIAIHDGPY----NYIKNWNYAGLIDVFNDEDGHGLGLKASTGAELEGAIKKALDN 519 Query: 517 IDGPVLVDVVVAKEE 531 GP L++ +A+++ Sbjct: 520 RRGPTLIECNIAQDD 534 >2JI6-A nrPDB Length = 568 Score = 429 bits (1103), Expect = e-120, Method: Composition-based stats. Identities = 115/554 (20%), Positives = 213/554 (38%), Gaps = 31/554 (5%) Query: 7 AYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQLSGE 66 + L+ + ++GV G + L+ G + S RHE+ A +AA + G+ Sbjct: 14 HVLIDALKMNDIDTMYGVVGIPITNLARMWQDDGQ-RFYSFRHEQHAGYAASIAGYIEGK 72 Query: 67 LAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSS--EIGSGYFQETHPQELFREC 124 VC PG L+ + L N P++ ++ ++ G ++E + R Sbjct: 73 PGVCLTVSAPGFLNGVTSLAHATTNCFPMILLSGSSEREIVDLQQGDYEEMDQMNVARPH 132 Query: 125 SHYCELVSSPEQIPQVLAIAMRKAVLNR-GVSVVVLPGDV---ALKPAPEGATMHWYHAP 180 ++S + IP +A A+R AV R G V LP + + + P Sbjct: 133 CKASFRINSIKDIPIGIARAVRTAVSGRPGGVYVDLPAKLFGQTISVEEANKLLFKPIDP 192 Query: 181 QPVVTPEEEELRKLAQLLRYSSNIALMCGSGCAGAH--KELVEFAGKIKAPIVHALRGKE 238 P P E+ + + A L++ + +M G G A A E+ + P + K Sbjct: 193 APAQIPAEDAIARAADLIKNAKRPVIMLGKGAAYAQCDDEIRALVEETGIPFLPMGMAKG 252 Query: 239 HVEYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPY-------RAFYPTDAKIIQI 291 + ++P ++ + D VL+G + + + + K +QI Sbjct: 253 LLPDNHPQSA-------AATRAFALAQCDVCVLIGARLNWLMQHGKGKTWGDELKKYVQI 305 Query: 292 DINPASIGAHSKVDMALVGDIKSTLRALLPLVE--EKADRKF---LDKALEDYRDARKGL 346 DI + ++ + +VGDIKS + L ++ KAD ++ L ++ + G Sbjct: 306 DIQANEMDSNQPIAAPVVGDIKSAVSLLRKALKGAPKADAEWTGALKAKVDGNKAKLAGK 365 Query: 347 DDLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYL-KMNGKRRLLGSFNH 405 PS + L A+ I + G + R + M R+ L S Sbjct: 366 MTAETPSGMMNYSNSLGVVRDFMLANPDISLVNEGANALDNTRMIVDMLKPRKRLDSGTW 425 Query: 406 GSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGF 465 G M M + A A + V+A+ GD F + ++ + LPV +++ NN + + Sbjct: 426 GVMGIGMGYCVAAAAVT-GKPVIAVEGDSAFGFSGMELETICRYNLPVTVIIMNNGGI-Y 483 Query: 466 VAMEMKAGGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDV 525 E + T L + + EA G G +E+ AL+ A + P L++ Sbjct: 484 KGNEADPQPGVISCTRLTRGRYDMMMEAFGGKGYVANTPAELKAALEEAVASGKPCLINA 543 Query: 526 VVAKEELAIPPQIK 539 ++ + +IK Sbjct: 544 MIDPDAGVESGRIK 557 >2VBF-A nrPDB Length = 570 Score = 429 bits (1103), Expect = e-120, Method: Composition-based stats. Identities = 117/566 (20%), Positives = 224/566 (39%), Gaps = 45/566 (7%) Query: 3 QTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQ 62 TV Y+ L G++ I+GV GD D + ++W+ +E A++ A A+ Sbjct: 25 YTVGDYLLDRLHELGIEEIFGVPGDYNLQFLDQIISREDMKWIGNANELNASYMADGYAR 84 Query: 63 LSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYF-QETHPQELF 121 + + A + G G L INGL + ++PV+ I S G F T F Sbjct: 85 -TKKAAAFLTTFGVGELSAINGLAGSYAENLPVVEIVGSPTSKVQNDGKFVHHTLADGDF 143 Query: 122 RECSHYCELVSS------PEQIPQVLAIAMRKAVLNRGVSVVVLPGDVALKPAPEGATMH 175 + E V++ E + + + + R + LP DVA A E + Sbjct: 144 KHFMKMHEPVTAARTLLTAENATYEIDRVLSQLLKERKPVYINLPVDVAAAKA-EKPALS 202 Query: 176 WYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSGCA--GAHKELVEFAGKIKAPIVHA 233 T E+ L K+ + L+ + ++ G G K + +F + K PI Sbjct: 203 LEKESSTTNTTEQVILSKIEESLKNAQKPVVIAGHEVISFGLEKTVTQFVSETKLPITTL 262 Query: 234 LRGKEHVEYDNPYDVGMT-GLIGFSSGFHTMMNADTLVLLGTQFPYR-----AFYPTDAK 287 GK V+ P +G+ G + S + + +AD +++LG + + + K Sbjct: 263 NFGKSAVDESLPSFLGIYNGKLSEISLKNFVESADFILMLGVKLTDSSTGAFTHHLDENK 322 Query: 288 IIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGLD 347 +I ++I+ I D D ++ + +L L + + +++DK E++ Sbjct: 323 MISLNIDEGIIFNKVVEDF----DFRAVVSSLSELKGIEYEGQYIDKQYEEFI------- 371 Query: 348 DLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGS 407 PS + L Q + + + GT + A + + R +G GS Sbjct: 372 ----PSSAPLSQDRLWQAVESLTQSNETIVAEQGTS-FFGASTIFLKSNSRFIGQPLWGS 426 Query: 408 MANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVA 467 + P ALG+Q + E + + GDG + + + ++ KL + NN Sbjct: 427 IGYTFPAALGSQIADKESRHLLFIGDGSLQLTVQELGLSIREKLNPICFIINNDGY---T 483 Query: 468 MEMKAGGYLTDGTELHDTNFARIAEACGITGIR-----VEKASEVDEALQRA-FSIDGPV 521 +E + G ++ N++++ E G T R V +E ++ A ++ Sbjct: 484 VEREIHGPTQSYNDIPMWNYSKLPETFGATEDRVVSKIVRTENEFVSVMKEAQADVNRMY 543 Query: 522 LVDVVVAKEELAIPPQIKLEQAKGFS 547 +++V+ KE+ P++ + K F+ Sbjct: 544 WIELVLEKED---APKLLKKMGKLFA 566 >5AHK-A nrPDB Length = 588 Score = 426 bits (1095), Expect = e-119, Method: Composition-based stats. Identities = 129/563 (22%), Positives = 241/563 (42%), Gaps = 33/563 (5%) Query: 7 AYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQLS-- 64 +AK L V + + G + L DS+N +G + +S HE+ AAFAA A ++++ Sbjct: 25 DAVAKILADNNVLYGFELIGGMITHLVDSINLLGKTKLVSMHHEQGAAFAASAVSRVTHH 84 Query: 65 GELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSS------EIGSGYFQETHPQ 118 L + + GPG +LI G+ DC + P + + + + +I FQE Sbjct: 85 KTLGLALATSGPGATNLITGIADCWLDSHPCIFLTGQVNTHELKGKRDIRQQGFQELDSV 144 Query: 119 ELFRECSHYCELVSSPEQIPQVLAIAMRKAVLNR-GVSVVVLPGDVALKPAPEGATMHWY 177 L + Y + S +++ L A++ A R G ++ +P D+ E A ++ Sbjct: 145 ALVTSITKYAYQIKSADELVPCLRKAIQIAKEGRPGPVLLDIPMDIQRADIDE-ALLNNP 203 Query: 178 HAPQPVVTPEE---EELRKLAQLLRYSSNIALMCGSGCAGAH--KELVEFAGKIKAPIVH 232 P+P V +L + L+ + L+ G G + ++ +E P V Sbjct: 204 MTPEPKVQRPSIAMSDLDFIINKLQNAKKPLLLIGGGAVNSSGFQKWLEQIELRGIPYVA 263 Query: 233 ALRGKEHVEYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPYRAF------YPTDA 286 +L+G E ++ + +GM G G + H + N D L++LG++ R + +A Sbjct: 264 SLKGAEKIKASD-LYLGMLGAYGTRAANHAVQNCDLLLVLGSRMDVRQTGAQPEDFARNA 322 Query: 287 KIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGL 346 +IIQID+ + D + ++ PL + + AL + + Sbjct: 323 EIIQIDLQEGQLNNRVIADFSYQIELSEYFSRFSPLQIPVNNDWSVWTALLKEKFRVTFI 382 Query: 347 DDLAKPSEKAIHPQYLAQQISHFAADDAI-FTCDVGTPTVWAARYLKMNGKRRLLGSFNH 405 D+ + + P L Q++ A+ + DVG +WAA L++N ++ + S Sbjct: 383 DEYTTWN---LSPFGLFTQLNKLTERVALDYILDVGNNQMWAAHTLRLNAQQAMHHSGGL 439 Query: 406 GSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGF 465 GSM A+P A+GA ++ ++ + GDGG + + + + + KLP+ +V NN LG Sbjct: 440 GSMGFAIPAAIGA-CYAGKKPIIVITGDGGAQLNIQELDIIARDKLPILTIVMNNHSLGM 498 Query: 466 VAMEMK---AGGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVL 522 V + G + + + F +I EA + + AL+ P+L Sbjct: 499 VRGFQEMYFEGRNSSTYWNGYTSQFKKIGEAYRVESKTIISMQAFSSALESFLESPRPLL 558 Query: 523 VDVVVAKEELAIPPQIKLEQAKG 545 ++V ++ P +LE + Sbjct: 559 LEVSMSDARECRP---RLEYGRA 578 >4ZP1-A nrPDB Length = 568 Score = 417 bits (1073), Expect = e-117, Method: Composition-based stats. Identities = 113/559 (20%), Positives = 225/559 (40%), Gaps = 44/559 (7%) Query: 1 MKQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAE 60 M TV Y+A+ L G+K + V GD L D+L +E + +E F+A Sbjct: 1 MSYTVGTYLAERLVQIGLKHHFAVAGDYNLVLLDNLLLNKNMEQVYCCNELNCGFSAEGY 60 Query: 61 AQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYF-------- 112 A+ G A + G L + + + ++PV+ I+ +++ +G+ Sbjct: 61 ARAKGAAAAV-VTYSVGALSAFDAIGGAYAENLPVILISGAPNNNDHAAGHVLHHALGKT 119 Query: 113 QETHPQELFRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDV----ALKPA 168 + E+ + + E + +PE+ P + ++ A+ + + + ++ P Sbjct: 120 DYHYQLEMAKNITAAAEAIYTPEEAPAKIDHVIKTALREKKPVYLEIACNIASMPCAAPG 179 Query: 169 PEGATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSG--CAGAHKELVEFAGKI 226 P A + + + + + + + + +A++ GS AGA + V+FA + Sbjct: 180 PASALFNDEASDEASLNAA---VEETLKFIANRDKVAVLVGSKLRAAGAEEAAVKFADAL 236 Query: 227 KAPIVHALRGKEHVEYDNPYDVGMT-GLIGFSSGFHTMMNADTLVLLGTQFPYRAFYPTD 285 + K +NP+ +G + G + + TM AD ++ L F Y T Sbjct: 237 GGAVATMAAAKSFFPEENPHYIGTSWGEVSYPGVEKTMKEADAVIALAPVFND---YSTT 293 Query: 286 AKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKG 345 D + V + + L+ L + +K +K AL+ ++ G Sbjct: 294 GWTDIPDPKKLVLAEPRSVVVNGIRFPSVHLKDYLTRLAQKVSKK--TGALDFFKSLNAG 351 Query: 346 LDDLAKPSEK--AIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSF 403 A P++ + +A+Q+ + + G A R NG R Sbjct: 352 ELKKAAPADPSAPLVNAEIARQVEALLTPNTTVIAETGDSWFNAQRMKLPNGARVEY-EM 410 Query: 404 NHGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVL 463 G + ++P A G PER+ + M GDG F + + +V++KLPV I + NN Sbjct: 411 QWGHIGWSVPAAFGYAVGAPERRNILMVGDGSFQLTAQEVAQMVRLKLPVIIFLINN--Y 468 Query: 464 GF-VAMEMKAGGYLTDGTELHDTNFARIAEACG---------ITGIRVEKASEVDEALQR 513 G+ +A+ + G Y + + ++A + E G++ + E+ EA++ Sbjct: 469 GYTIAVMIHDGPY----NNIKNWDYAGLMEVFNGNGGYDSGAGKGLKAKTGGELAEAIKV 524 Query: 514 AF-SIDGPVLVDVVVAKEE 531 A + DGP L++ + +E+ Sbjct: 525 ALANTDGPTLIECFIGRED 543 >1OVM-A nrPDB Length = 552 Score = 417 bits (1073), Expect = e-117, Method: Composition-based stats. Identities = 118/562 (20%), Positives = 212/562 (37%), Gaps = 53/562 (9%) Query: 3 QTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQ 62 VA Y+ L G ++GV GD D + I W+ +E A++AA A+ Sbjct: 5 YCVADYLLDRLTDCGADHLFGVPGDYNLQFLDHVIDSPDICWVGCANELNASYAADGYAR 64 Query: 63 LSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYF-QETHPQELF 121 G A + G G L +NG+ + HVPVL I ++ G T F Sbjct: 65 CKG-FAALLTTFGVGELSAMNGIAGSYAEHVPVLHIVGAPGTAAQQRGELLHHTLGDGEF 123 Query: 122 RECSHYCELVSSPE----------QIPQVLAIAMRKAVLNRGVSVVVLPGDVALKPA--P 169 R H E ++ + +I +VL +R R ++LP DVA K A P Sbjct: 124 RHFYHMSEPITVAQAVLTEQNACYEIDRVLTTMLR----ERRPGYLMLPADVAKKAATPP 179 Query: 170 EGATMH-WYHAPQPVVTPEEEELRKLAQLLRYSSNIA--LMCGSGCAGAHKELVEFAGKI 226 A H HA + + + + ++ +A L+ G A ++ V+ Sbjct: 180 VNALTHKQAHADSACLKAFRDAAENKLAMSKRTALLADFLVLRHGLKHALQKWVKEVPMA 239 Query: 227 KAPIVHALRGKEHVEYDNPYDVGMT-GLIGFSSGFHTMMNADTLVLLGTQFPYR-----A 280 L GK + G G + + ADT++ +GT+F Sbjct: 240 H---ATMLMGKGIFDERQAGFYGTYSGSASTGAVKEAIEGADTVLCVGTRFTDTLTAGFT 296 Query: 281 FYPTDAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYR 340 T A+ I++ + A +G + + + L+ L ++ + + Sbjct: 297 HQLTPAQTIEVQPHAARVGDVWFTGIP----MNQAIETLVELCKQHVHAGLMSSS----- 347 Query: 341 DARKGLDDLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLL 400 G +P ++ + + + F I D GT A L++ + Sbjct: 348 ---SGAIPFPQPD-GSLTQENFWRTLQTFIRPGDIILADQGTSAFGAID-LRLPADVNFI 402 Query: 401 GSFNHGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNN 460 GS+ + A GAQ P R+V+ + GDG + + + S+++ K I+V NN Sbjct: 403 VQPLWGSIGYTLAAAFGAQTACPNRRVIVLTGDGAAQLTIQELGSMLRDKQHPIILVLNN 462 Query: 461 SVLGFVAMEMKAGGYLTDGTELHDTNFARIAEACGIT----GIRVEKASEVDEALQRAFS 516 +E G ++ N+ I +A + RV +A ++ + L++ Sbjct: 463 EGY---TVERAIHGAEQRYNDIALWNWTHIPQALSLDPQSECWRVSEAEQLADVLEKVAH 519 Query: 517 IDGPVLVDVVVAKEELAIPPQI 538 + L++V++ K + IPP + Sbjct: 520 HERLSLIEVMLPKAD--IPPLL 539 >2Q28-A nrPDB Length = 564 Score = 417 bits (1071), Expect = e-117, Method: Composition-based stats. Identities = 120/541 (22%), Positives = 228/541 (42%), Gaps = 28/541 (5%) Query: 7 AYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQLSGE 66 I + L+ + I+GV G + ++ G I ++ RHE+ A +AA A L+ + Sbjct: 12 HIIVEALKQNNIDTIYGVVGIPVTDMARHAQAEG-IRYIGFRHEQSAGYAAAASGFLTQK 70 Query: 67 LAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSS--EIGSGYFQETHPQELFREC 124 +C PG L+ + L + N P++ I+ + ++ G ++E + Sbjct: 71 PGICLTVSAPGFLNGLTALANATVNGFPMIMISGSSDRAIVDLQQGDYEELDQMNAAKPY 130 Query: 125 SHYCELVSSPEQIPQVLAIAMRKAVLNR-GVSVVVLPGDV---ALKPAPEGATMHWYHAP 180 + V+ P+ + LA A+R +V R G + LP +V ++ T+ P Sbjct: 131 AKAAFRVNQPQDLGIALARAIRVSVSGRPGGVYLDLPANVLAATMEKDEALTTIVKVENP 190 Query: 181 QPVVTPEEEELRKLAQLLRYSSNIALMCGSGCA--GAHKELVEFAGKIKAPIVHALRGKE 238 P + P + + LL + ++ G G A A ++L EF + P + K Sbjct: 191 SPALLPCPKSVTSAISLLAKAERPLIILGKGAAYSQADEQLREFIESAQIPFLPMSMAKG 250 Query: 239 HVEYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPY-----RAFYPTDAKIIQIDI 293 +E +P ++ + NAD ++L+G + + + + D + IQ+DI Sbjct: 251 ILEDTHPLSA-------AAARSFALANADVVMLVGARLNWLLAHGKKGWAADTQFIQLDI 303 Query: 294 NPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLD----KALEDYRDARKGLDDL 349 P I ++ + + +VGDI S+++ +L +++ L + ++A+K + L Sbjct: 304 EPQEIDSNRPIAVPVVGDIASSMQGMLAELKQNTFTTPLVWRDILNIHKQQNAQKMHEKL 363 Query: 350 AKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAAR-YLKMNGKRRLLGSFNHGSM 408 + ++ + L+ + I+ + G T+ AR + M RR L G M Sbjct: 364 STDTQPLNYFNALSAVRDVLRENQDIYLVNEGANTLDNARNIIDMYKPRRRLDCGTWGVM 423 Query: 409 ANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSV-LGFVA 467 M A+GA T VVA+ GD F + ++ + LPV IV+FNN Sbjct: 424 GIGMGYAIGASVTS-GSPVVAIEGDSAFGFSGMEIETICRYNLPVTIVIFNNGGIYRGDG 482 Query: 468 MEMKAGGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDVVV 527 +++ G + LH + ++ +A G V E+ AL P +++VV+ Sbjct: 483 VDLSGAGAPSPTDLLHHARYDKLMDAFRGVGYNVTTTDELRHALTTGIQSRKPTIINVVI 542 Query: 528 A 528 Sbjct: 543 D 543 >2PGN-A nrPDB Length = 589 Score = 416 bits (1069), Expect = e-116, Method: Composition-based stats. Identities = 123/546 (22%), Positives = 224/546 (41%), Gaps = 19/546 (3%) Query: 4 TVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEE--VAAFAAGAEA 61 A I + LE G +++ G G + + ++D+ ++ + + E A G Sbjct: 5 RGADLIVEALEEYGTEQVVGFIGHTSHFVADAFSKSHLGKRVINPATELGGAWMVNGYNY 64 Query: 62 QLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELF 121 AV A C GNL L + + +P + I + G + P + F Sbjct: 65 VKDRSAAVGAWHC-VGNLLLHAAMQEARTGRIPAVHIGLNSDGRLAGRSEAAQQVPWQSF 123 Query: 122 RECSHYCELVSSPEQIPQVLAIAMRKAVLNR-GVSVVVLPGDVALKPAPEGATMHWYHA- 179 + + V +++ + + A R A + G + V +P D+ + A + Sbjct: 124 TPIARSTQRVERLDKVGEAIHEAFRVAEGHPAGPAYVDIPFDLTADQIDDKALVPRGATR 183 Query: 180 PQPVVTPEEEELRKLAQLLRYSSNIALMCGSGCA--GAHKELVEFAGKIKAPIVHALRGK 237 + V+ E++R+ A L + N ++ G G A G + L++ A + P+V G Sbjct: 184 AKSVLHAPNEDVREAAAQLVAAKNPVILAGGGVARSGGSEALLKLAEMVGVPVVTTSTGA 243 Query: 238 EHVEYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPY----RAFYPTDAKIIQIDI 293 + +G G G+ S M AD +++LG++ + + K + +D Sbjct: 244 GVFPETHALAMGSAGFCGWKSANDMMAAADFVLVLGSRLSDWGIAQGYITKMPKFVHVDT 303 Query: 294 NPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLD-KALEDYRDA---RKGLDDL 349 +PA +G +++V D K+ + L+ ++ + K + + E++R A R D Sbjct: 304 DPAVLGTFYFPLLSVVADAKTFMEQLIEVLPGTSGFKAVRYQERENFRQATEFRAAWDGW 363 Query: 350 AKPSEKAI-HPQYLAQ---QISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNH 405 + E P + + ++ + I D+G T+ + RRL+ S Sbjct: 364 VREQESGDGMPASMFRAMAEVRKVQRPEDIIVTDIGNHTLPMFGGAILQRPRRLVTSMAE 423 Query: 406 GSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGF 465 G + P ALGAQ EP +V GDG +F V+ KLPV +VF N G Sbjct: 424 GILGCGFPMALGAQLAEPNSRVFLGTGDGALYYHFNEFRVAVEHKLPVITMVFTNESYGA 483 Query: 466 VAMEMKAGGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDV 525 M + TE + ++ IA+A G G V + ++ ALQRA P L+++ Sbjct: 484 NWTLMNHQFGQNNWTEFMNPDWVGIAKAFGAYGESVRETGDIAGALQRAIDSGKPALIEI 543 Query: 526 VVAKEE 531 V+K + Sbjct: 544 PVSKTQ 549 >4QQ8-A nrPDB Length = 583 Score = 412 bits (1060), Expect = e-115, Method: Composition-based stats. Identities = 122/557 (21%), Positives = 224/557 (40%), Gaps = 23/557 (4%) Query: 3 QTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQ 62 T + +TL AGV+ ++G+ G ++ + + + + TRHE A AA A+ Sbjct: 4 ITGGELVVRTLIKAGVEHLFGLHGIHIDTIFQACLD-HDVPIIDTRHEAAAGHAAEGYAR 62 Query: 63 LSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQE-THPQELF 121 +L V + G G + + + + + PVL + + + Q + Sbjct: 63 AGAKLGVALVTAGGGFTNAVTPIANARTDRTPVLFLTGSGALRDDETNTLQAGIDQVAMA 122 Query: 122 RECSHYCELVSSPEQIPQVLAIAMRKAVL-NRGVSVVVLPGDVALKPAPEGAT-MHWYHA 179 + + V + E IP+++ A+R A+ RG ++ LP D+ + E + + Sbjct: 123 APITKWAHRVMATEHIPRLVMQAIRAALSAPRGPVLLDLPWDILMNQIDEDSVIIPDLVL 182 Query: 180 PQPVVTPEEEELRKLAQLLRYSSNIALMCGSGCAGAHK--ELVEFAGKIKAPIVHALRGK 237 P+ +L + LLR + ++ GS + + L F P+ G Sbjct: 183 SAHGAHPDPADLDQALALLRKAERPVIVLGSEASRTARKTALSAFVAATGVPVFADYEGL 242 Query: 238 EHVEYDNPYDVGMTGLIGFSSGFHTMMNA-DTLVLLGTQFPYRA------FYPTDAKIIQ 290 + D GL+ F A D +++LG +F P A++IQ Sbjct: 243 SML--SGLPDAMRGGLVQNLYSFAKADAAPDLVLMLGARFGLNTGHGSGQLIPHSAQVIQ 300 Query: 291 IDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKA---DRKFLDKALEDYRDARKGLD 347 +D + +G + + +V D+ T+ AL + A DR + D R Sbjct: 301 VDPDACELGRLQGIALGIVADVGGTIEALAQATAQDAAWPDRGDWCAKVTDLAQERYASI 360 Query: 348 DLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGS 407 SE A+HP + +Q I+ D G +W + + L S Sbjct: 361 AAKSSSEHALHPFHASQVIAKHVDAGVTVVADGGLTYLWLSEVMSRVKPGGFLCHGYLNS 420 Query: 408 MANAMPQALGAQATEPE--RQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGF 465 M ALGAQ + E R+ + + GDG +G+F ++V+ +LP+ +++ NN G+ Sbjct: 421 MGVGFGTALGAQVADLEAGRRTILVTGDGSVGYSIGEFDTLVRKQLPLIVIIMNNQSWGW 480 Query: 466 VA--MEMKAGGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLV 523 ++ G GT L + ++ +A A G G V+ AL +A + + P + Sbjct: 481 TLHFQQLAVGPNRVTGTRLENGSYHGVAAAFGADGYHVDSVESFSAALAQALAHNRPACI 540 Query: 524 DVVVAKEELAIPPQIKL 540 +V VA + P ++ L Sbjct: 541 NVAVAL-DPIPPEELIL 556 >4COK-A nrPDB Length = 558 Score = 408 bits (1049), Expect = e-114, Method: Composition-based stats. Identities = 106/554 (19%), Positives = 205/554 (37%), Gaps = 42/554 (7%) Query: 1 MKQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAE 60 M TV Y+A L G+K + V GD L D L ++ + +E F+A Sbjct: 1 MTYTVGRYLADRLAQIGLKHHFAVAGDYNLVLLDQLLLNTDMQQIYCSNELNCGFSAEGY 60 Query: 61 AQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQET----- 115 A+ + A + G L N L + ++PV+ I+ +++ G+G+ Sbjct: 61 ARAN-GAAAAIVTFSVGALSAFNALGGAYAENLPVILISGAPNANDHGTGHILHHTLGTT 119 Query: 116 ---HPQELFRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDVALKP-APEG 171 + E+ R + E + + E P + +R A+ + + + + +VA P G Sbjct: 120 DYGYQLEMARHITCAAESIVAAEDAPAKIDHVIRTALREKKPAYLEIACNVAGAPCVRPG 179 Query: 172 ATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSGC--AGAHKELVEFAGKIKAP 229 P P + + + ++ ++ GS AGA + V A + Sbjct: 180 GIDALLSPPAPDEASLKAAVDAALAFIEQRGSVTMLVGSRIRAAGAQAQAVALADALGCA 239 Query: 230 IVHALRGKEHVEYDNPYDVGMT-GLIGFSSGFHTMMNADTLVLLGTQFPYRAF-----YP 283 + K D+P G G + + AD ++ L F A +P Sbjct: 240 VTTMAAAKSFFPEDHPGYRGHYWGEVSSPGAQQAVEGADGVICLAPVFNDYATVGWSAWP 299 Query: 284 TDAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDAR 343 ++ ++ + ++G + + D++ L L + + A Sbjct: 300 KGDNVMLVERHAVTVGGVAYAGI----DMRDFLTRLAAHTVRRDATARGGAYVTPQTPAA 355 Query: 344 KGLDDLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSF 403 ++ +A+QI T + G A R +G R L Sbjct: 356 A--------PTAPLNNAEMARQIGALLTPRTTLTAETGDSWFNAVRMKLPHGARVEL-EM 406 Query: 404 NHGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVL 463 G + ++P A G PERQ V M GDG F + + +++ LPV I + NN Sbjct: 407 QWGHIGWSVPAAFGNALAAPERQHVLMVGDGSFQLTAQEVAQMIRHDLPVIIFLINNHGY 466 Query: 464 GFVAMEMKAGGYLTDGTELHDTNFARIAEACGI-----TGIRVEKASEVDEALQRA-FSI 517 + + + G Y + + ++A + E G+R E+ A+++A + Sbjct: 467 T-IEVMIHDGPY----NNVKNWDYAGLMEVFNAGEGNGLGLRARTGGELAAAIEQARANR 521 Query: 518 DGPVLVDVVVAKEE 531 +GP L++ + +++ Sbjct: 522 NGPTLIECTLDRDD 535 >6EFG-A nrPDB Length = 563 Score = 385 bits (990), Expect = e-107, Method: Composition-based stats. Identities = 99/564 (17%), Positives = 203/564 (35%), Gaps = 56/564 (9%) Query: 2 KQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEA 61 + T+ Y+ + L+ V+ I+G+ GD L D++ + + W +E AA+AA A Sbjct: 3 EITLGRYLFERLKQVEVQTIFGLPGDFNLSLLDNIYEVPGMRWAGNANELNAAYAADGYA 62 Query: 62 QLSGELAVCAGSCGPGNLHLINGLFDCHRN--------HVPVLAIAAH--IPSSEIGSGY 111 +L G ++ + G G L +NG+ + VP ++ A + +G+G Sbjct: 63 RLKG-MSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSVSSQAKQLLLHHTLGNGD 121 Query: 112 FQETHPQELFRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDVALKPAPEG 171 F H + S +++ P + +R +++ + LP ++ P Sbjct: 122 FTVFHR--MSSNISETTAMITDINTAPAEIDRCIRTTYVSQRPVYLGLPANLVDLTVPAS 179 Query: 172 ATMHWYHAPQPVVTPEEEE--LRKLAQLLRYSSNIALMCGSGCA--GAHKELVEFAGKIK 227 PE EE + + QL++ + N ++ + C+ A E + + Sbjct: 180 LLDTPIDLSLKPNDPEAEEEVIENVLQLIKEAKNPVILADACCSRHDAKAETKKLIDLTQ 239 Query: 228 APIVHALRGKEHVEYDNPYDVGM-TGLIGFSSGFHTMMNADTLVLLGTQFPYRAFYPTDA 286 P GK ++ +P G+ G + + + +AD ++ +G Sbjct: 240 FPAFVTPMGKGSIDEKHPRFGGVYVGTLSSPAVKEAVESADLVLSVGALLSD-------- 291 Query: 287 KIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGL 346 + S +K + D A P V+ K L K L DA KG Sbjct: 292 ----FNTGSFSYSYKTKNIVEFHSDYTKIRSATFPGVQMKF---ALQKLLTKVADAAKGY 344 Query: 347 DDLAKPSEK----------AIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGK 396 + PSE + +++ Q+ F + + + GT + N Sbjct: 345 KPVPVPSEPEHNEAVADSTPLKQEWVWTQVGEFLREGDVVITETGTSAFGINQTHFPNNT 404 Query: 397 RRLLGSFNHGSMAN----AMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLP 452 + GS+ + A A+ +P+++V+ GDG + + + ++++ L Sbjct: 405 YG-ISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLK 463 Query: 453 VKIVVFNNSVLGFVAMEMKAGGYLTDGTELHDTNFARIAEACGIT---GIRVEKASEVD- 508 + V NN +E G + + + G +RV E + Sbjct: 464 PYLFVLNNDGY---TIERLIHGETAQYNCIQNWQHLELLPTFGAKDYEAVRVSTTGEWNK 520 Query: 509 -EALQRAFSIDGPVLVDVVVAKEE 531 ++ L++V++ + Sbjct: 521 LTTDEKFQDNTRIRLIEVMLPTMD 544 >1QPB-A nrPDB Length = 563 Score = 380 bits (976), Expect = e-106, Method: Composition-based stats. Identities = 101/577 (17%), Positives = 204/577 (35%), Gaps = 59/577 (10%) Query: 2 KQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEA 61 + T+ Y+ + L+ V ++G+ GD L D + + + W +E AA+AA A Sbjct: 3 EITLGKYLFERLKQVNVNTVFGLPGDFNLSLLDKIYEVEGMRWAGNANELNAAYAADGYA 62 Query: 62 QLSGELAVCAGSCGPGNLHLINGLFDCHRN--------HVPVLAIAAH--IPSSEIGSGY 111 ++ G ++ + G G L +NG+ + VP ++ A + +G+G Sbjct: 63 RIKG-MSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSISAQAKQLLLHHTLGNGD 121 Query: 112 FQETHPQELFRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDVALKPAPEG 171 F H + S +++ P + +R + + + LP ++ P Sbjct: 122 FTVFHR--MSANISETTAMITDIATAPAEIDRCIRTTYVTQRPVYLGLPANLVDLNVPAK 179 Query: 172 --ATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSGCAGAH--KELVEFAGKIK 227 T E+E + + L++ + N ++ + C+ E + + Sbjct: 180 LLQTPIDMSLKPNDAESEKEVIDTILVLIKDAKNPVILADACCSRHDVKAETKKLIDLTQ 239 Query: 228 APIVHALRGKEHVEYDNPYDVGM-TGLIGFSSGFHTMMNADTLVLLGTQFPYRAFYPTDA 286 P GK ++ +P G+ G + + +AD ++ +G Sbjct: 240 FPAFVTPMGKGSIDEQHPRYGGVYVGTLSKPEVKEAVESADLILSVGALLSD-------- 291 Query: 287 KIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGL 346 + S +K + D A P V+ K L K L DA KG Sbjct: 292 ----FNTGSFSYSYKTKNIVEFHSDHMKIRNATFPGVQMKF---VLQKLLTAIADAAKGY 344 Query: 347 DD----------LAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGK 396 A P+ + +++ Q+ +F + + + GT + N Sbjct: 345 KPVAVPARTPANAAVPASTPLKQEWMWNQLGNFLQEGDVVIAETGTSAFGINQTTFPNNT 404 Query: 397 RRLLGSFNHGSMAN----AMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLP 452 + GS+ + A A+ +P+++V+ GDG + + + ++++ L Sbjct: 405 YG-ISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLK 463 Query: 453 VKIVVFNNSVLGFVAMEMKAGGYLTDGTELHDTNFARIAEACGITGI---RVEKASEVDE 509 + V NN +E G E+ + + G RV E D+ Sbjct: 464 PYLFVLNNDGY---TIEKLIHGPKAQYNEIQGWDHLSLLPTFGAKDYETHRVATTGEWDK 520 Query: 510 ALQ--RAFSIDGPVLVDVVVAKEELAIPPQIKLEQAK 544 Q +++V++ + PQ +EQAK Sbjct: 521 LTQDKSFNDNSKIRMIEVMLPVFD---APQNLVEQAK 554 >1UPC-A nrPDB Length = 573 Score = 363 bits (932), Expect = e-101, Method: Composition-based stats. Identities = 117/564 (20%), Positives = 214/564 (37%), Gaps = 47/564 (8%) Query: 2 KQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEA 61 K T A + L GV +++GV G + + + I+++ TRHE A AA A Sbjct: 11 KPTAAHALLSRLRDHGVGKVFGVVGREAASIL--FDEVEGIDFVLTRHEFTAGVAADVLA 68 Query: 62 QLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEI-GSGYFQETHPQEL 120 +++G C + GPG +L G+ + PV+A+AA S +I + Q + Sbjct: 69 RITGRPQACWATLGPGMTNLSTGIATSVLDRSPVIALAAQSESHDIFPNDTHQCLDSVAI 128 Query: 121 FRECSHYCELVSSPEQIPQVLAIAMRKAVLNR-GVSVVVLPGDVALKPAPEGATMHWYHA 179 S Y + P +I ++ A+ A+ G S + LP D+ T+ Sbjct: 129 VAPMSKYAVELQRPHEITDLVDSAVNAAMTEPVGPSFISLPVDLLGSSEGIDTTV----- 183 Query: 180 PQPVVTPEEEELRKLAQ-----------LLRYSSNIALMCGSGC--AGAHKELVEFAGKI 226 P P + + +A LL + + L+ G+ +GA + A ++ Sbjct: 184 PNPPANTPAKPVGVVADGWQKAADQAAALLAEAKHPVLVVGAAAIRSGAVPAIRALAERL 243 Query: 227 KAPIVHALRGKEHVEYDNPYDVG-----MTGLIGFSSGFHTMMNADTLVLLGTQF----- 276 P++ K + + + G M G++ F + D ++ +G + Sbjct: 244 NIPVITTYIAKGVLPVGHELNYGAVTGYMDGILNFPALQTMFAPVDLVLTVGYDYAEDLR 303 Query: 277 PYRAFYPTDAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKAL 336 P + K ++I I + D+ +V D+ + + E A F K Sbjct: 304 PSMWQKGIEKKTVRISPTVNPIPRVYRPDVDVVTDVLAFVEHF-----ETATASFGAKQR 358 Query: 337 EDYRDARKGLDDLAKPSEKAIHPQYLAQQISHF--------AADDAIFTCDVGTPTVWAA 388 D R + + E + Q I + D+G + Sbjct: 359 HDIEPLRARIAEFLADPETYEDGMRVHQVIDSMNTVMEEAAEPGEGTIVSDIGFFRHYGV 418 Query: 389 RYLKMNGKRRLLGSFNHGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQ 448 + + + L S S +P A+GAQ P++ + GDGGF D ++ + Sbjct: 419 LFARADQPFGFLTSAGCSSFGYGIPAAIGAQMARPDQPTFLIAGDGGFHSNSSDLETIAR 478 Query: 449 MKLPVKIVVFNNSVLGFVAMEMKAGGYLT--DGTELHDTNFARIAEACGITGIRVEKASE 506 + LP+ VV NN G + + G + + + +F +AEA G+ R E Sbjct: 479 LNLPIVTVVVNNDTNGLIELYQNIGHHRSHDPAVKFGGVDFVALAEANGVDATRATNREE 538 Query: 507 VDEALQRAFSIDGPVLVDVVVAKE 530 + AL++ + P L++V V + Sbjct: 539 LLAALRKGAELGRPFLIEVPVNYD 562 >2Q5O-A nrPDB Length = 565 Score = 363 bits (932), Expect = e-100, Method: Composition-based stats. Identities = 108/543 (19%), Positives = 210/543 (38%), Gaps = 41/543 (7%) Query: 5 VAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQLS 64 +A + + L+ G + ++G+ GD + + HE FAA A A+ S Sbjct: 23 LAEALLRALKDRGAQAMFGIPGDFALPFFKVAEETQILPLHTLSHEPAVGFAADAAARYS 82 Query: 65 GELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQEL---- 120 L V A + G G +++N + + PV+ I+ ++E +G + L Sbjct: 83 STLGVAAVTYGAGAFNMVNAVAGAYAEKSPVVVISGAPGTTEGNAGLLLHHQGRTLDTQF 142 Query: 121 --FRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGD-VALKPAPEGATMHWY 177 F+E + + P + P +A + A + +P + V + P G W Sbjct: 143 QVFKEITVAQARLDDPAKAPAEIARVLGAARAQSRPVYLEIPRNMVNAEVEPVGDDPAWP 202 Query: 178 HAPQPVVTPEEEELRKLAQLLRYSSNIALMCGS-GCAGAHKELVEFAGKIKAPIVHALRG 236 + +E L A + +S + ++C G ++ E A ++ P+V G Sbjct: 203 VDRDALAACADEVL---AAMRSATSPVLMVCVEVRRYGLEAKVAELAQRLGVPVVTTFMG 259 Query: 237 KEHV-EYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPYRAFYPTDAKI-----IQ 290 + + + P G+ G + + +D L LLG F + KI I Sbjct: 260 RGLLADAPTPPLGTYIGVAGDAEITRLVEESDGLFLLGAILSDTNFAVSQRKIDLRKTIH 319 Query: 291 IDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGLDDLA 350 ++G H+ D+ L G + + L L P +DR K Y + Sbjct: 320 AFDRAVTLGYHTYADIPLAGLVDALLERLPP-----SDRTTRGKEPHAYPTGLQA----- 369 Query: 351 KPSEKAIHPQYLAQQISH---FAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGS 407 + I P +A+ ++ + + D+G A + L+ + Sbjct: 370 --DGEPIAPMDIARAVNDRVRAGQEPLLIAADMGDCLFTAMDMIDAG----LMAPGYYAG 423 Query: 408 MANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVA 467 M +P +GAQ ++++ + GDG F M + + ++ + +++FNN+ + Sbjct: 424 MGFGVPAGIGAQCVSGGKRILTVVGDGAFQMTGWELGNCRRLGIDPIVILFNNASWEMLR 483 Query: 468 MEMKAGGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPV-LVDVV 526 + +L D FA +A G G+RV +E+ AL +AF+ G L++ + Sbjct: 484 TFQPESAF----NDLDDWRFADMAAGMGGDGVRVRTRAELKAALDKAFATRGRFQLIEAM 539 Query: 527 VAK 529 + + Sbjct: 540 IPR 542 >6A50-A nrPDB Length = 549 Score = 360 bits (924), Expect = e-100, Method: Composition-based stats. Identities = 108/527 (20%), Positives = 207/527 (39%), Gaps = 27/527 (5%) Query: 11 KTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQLSGELAVC 70 + L G+ ++G G + ++ E A AQ S + A Sbjct: 31 ELLRRQGIDTVFGNPGSNELPFLKDFPE--DFRYILALQEACVVGIADGYAQASRKPAFI 88 Query: 71 AGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGY-FQETHPQELFRECSHYCE 129 G + + L + +H P++ A + IG L R + Sbjct: 89 NLHSAAGTGNAMGALSNARTSHSPLIVTAGQQTRAMIGVEAGETNVDAANLPRPLVKWSY 148 Query: 130 LVSSPEQIPQVLAIAMRKA-VLNRGVSVVVLPGDVALKPAPEGATMHWYHAPQPVVTPEE 188 +S ++P ++ A+ A + +G + +P D K A + + V + Sbjct: 149 EPASAAEVPHAMSRAIHMASMAPQGPVYLSVPYDDWDKDADPQSHHLFDRHVSSSVRLND 208 Query: 189 EELRKLAQLLRYSSNIALMCGSG--CAGAHKELVEFAGKIKAPIVHALRG-KEHVEYDNP 245 ++L L + L +SN A++ G A A+ + V A ++KAP+ A + +P Sbjct: 209 QDLDILVKALNSASNPAIVLGPDVDAANANADCVMLAERLKAPVWVAPSAPRCPFPTRHP 268 Query: 246 YDVGMTGLIGFSSGFHTMMNADTLVLLGTQ------FPYRAFYPTDAKIIQIDINPASIG 299 G+ G ++ + D ++++G + + ++I + +P Sbjct: 269 CFRGLMP-AGIAAISQLLEGHDVVLVIGAPVFRYVFYDPGQYLKPGTRLISVTCDPLE-A 326 Query: 300 AHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGLDDLAKPSEKAIHP 359 A + + A+V DI + AL LVEE + R+ A E + +HP Sbjct: 327 ARAPMGDAIVADIGAMASALANLVEE-SSRQLPTAAPEPAK---------VDQDAGRLHP 376 Query: 360 QYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAMPQALGAQ 419 + + ++ A ++AI+ + + T + L M G + A+P A+G Q Sbjct: 377 ETVFDTLNDMAPENAIYLNESTSTTAQMWQRLNMRNPGSYYFCAA-GGLGFALPAAIGVQ 435 Query: 420 ATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFV-AMEMKAGGYLTD 478 EPERQV+A+ GDG + + + Q +P V+ NN G + Sbjct: 436 LAEPERQVIAVIGDGSANYSISALWTAAQYNIPTIFVIMNNGTYGMLRWFAGVLEAENVP 495 Query: 479 GTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDV 525 G ++ +F +A+ G+ ++ + ++ +LQ A S GPVL++V Sbjct: 496 GLDVPGIDFRALAKGYGVQALKADNLEQLKGSLQEALSAKGPVLIEV 542 >4Q9D-A nrPDB Length = 545 Score = 356 bits (914), Expect = 1e-98, Method: Composition-based stats. Identities = 113/539 (20%), Positives = 197/539 (36%), Gaps = 32/539 (5%) Query: 4 TVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQL 63 TV L G+ ++G G + ++ + E A A AQ Sbjct: 6 TVHDVTYDLLRKLGLTTVFGNPGSTEESFLRDFPE--DFTYVLSLQEASALAMADGFAQA 63 Query: 64 SGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAH-IPSSEIGSGYFQETHPQELFR 122 +G+ A+ G + + L +R + P++ A + Y + + Sbjct: 64 TGKPALVNLHTAAGTGNAMGSLVAAYRANTPLIITAGQQTREMSVVDPYLNNPDATTMPK 123 Query: 123 ECSHYCELVSSPEQIPQVLAIAMRKAVLNR-GVSVVVLPGDVALKPAPEGATMHWYHAPQ 181 + + E +P A A+ G + +P D KPA A + Sbjct: 124 PWVKWSYEPARAEDVPAAFMQAYAVAMQPPMGPVFLSIPLDDWDKPALGPAAVRSV---S 180 Query: 182 PVVTPEEEELRKLAQLLRYSSNIALMCGSGC--AGAHKELVEFAGKIKAPI-VHALRGKE 238 V P+ E L + A+ + + + L+ G AGA +EFA K+ AP+ AL + Sbjct: 181 TRVAPDAERLAQFAERINAAKHPMLVLGPEVDRAGAWDAGIEFAEKLGAPVHASALPDRM 240 Query: 239 HVEYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQ----FPYRA--FYPTDAKIIQID 292 D+P G + + + D +V++G + +PY + P ++QI Sbjct: 241 SFPEDHPLYAGPLPMT-IAGVEQAVSAYDLVVVVGAEVFRYYPYVPGEYLPEGTDLLQIT 299 Query: 293 INPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGLDDLAKP 352 +P A + V +LVGD+ L L L++ DR K L R + P Sbjct: 300 ADPHR-SAVAPVGDSLVGDVGIALSRLTELIDTPDDR-VPPKPLVRQRHS-------DIP 350 Query: 353 SEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAM 412 S + + + +S+ DDA + + + +L + + G + + Sbjct: 351 STAPMTSNAVYEVLSNVKPDDAAVVMESTSTMLDLFTWLPTTHPASFFATGS-GGIGWGV 409 Query: 413 PQALGAQATEP----ERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAM 468 P A+G + +R VVA GDG F + + Q KLP+ VV N + Sbjct: 410 PAAVGIALGDRARGVDRTVVATIGDGSFQYSIQAIWTAAQHKLPIVFVVLRNGEYAILKS 469 Query: 469 EMK-AGGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDVV 526 G +L + + IA G VE ++ L+ A DGP ++ V Sbjct: 470 FADLEKTPNVPGLQLPGLDISSIAAGFGCRTATVESTDMLEAELKTALQADGPTVLVVP 528 >4K9Q-A nrPDB Length = 539 Score = 351 bits (900), Expect = 5e-97, Method: Composition-based stats. Identities = 108/543 (19%), Positives = 194/543 (35%), Gaps = 34/543 (6%) Query: 4 TVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQL 63 TV L V + G G + ++ E A +Q Sbjct: 3 TVKEITFDLLRKLQVTTVVGNPGSTEETFLKDF--PSDFNYVLALQEASVVAIADGLSQS 60 Query: 64 SGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAH-IPSSEIGSGYFQETHPQELFR 122 + + G G + + L ++N P++ A + + + Sbjct: 61 LRKPVIVNIHTGAGLGNAMGCLLTAYQNKTPLIITAGQQTREMLLNEPLLTNIEAINMPK 120 Query: 123 ECSHYCELVSSPEQIPQVLAIAMRKAVL-NRGVSVVVLPGDVALKPAPEGATMHWYHAPQ 181 + + PE +P A A+ +G + LP D K PE Q Sbjct: 121 PWVKWSYEPARPEDVPGAFMRAYATAMQQPQGPVFLSLPLDDWEKLIPEVDVARTVSTRQ 180 Query: 182 PVVTPEEEELRKLAQLLRYSSNIALMCGSGCA--GAHKELVEFAGKIKAPIVHALRG-KE 238 P+ +++++ AQ + S N L+ GS A A + + FA ++ AP+ A + Sbjct: 181 ---GPDPDKVKEFAQRITASKNPLLIYGSDIARSQAWSDGIAFAERLNAPVWAAPFAERT 237 Query: 239 HVEYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQ----FPYRA--FYPTDAKIIQID 292 D+P G G S + D +V++G +P+ A F P + ++Q+ Sbjct: 238 PFPEDHPLFQGAL-TSGIGSLEKQIQGHDLIVVIGAPVFRYYPWIAGQFIPEGSTLLQVS 296 Query: 293 INPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGLDDLAKP 352 +P ++ + + V +LV D K L L L++++ K R D A P Sbjct: 297 DDP-NMTSKAVVGDSLVSDSKLFLIEALKLIDQRE------KNNTPQRSPMTKEDRTAMP 349 Query: 353 SEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAM 412 + P + + + + + + + + ++N F G + + Sbjct: 350 ----LRPHAVLEVLKENSPKEIVLVEECPSIVPLMQDVFRINQPDTFYT-FASGGLGWDL 404 Query: 413 PQA----LGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAM 468 P A LG + + R VV + GDG F + + VQ K V VVF N G + Sbjct: 405 PAAVGLALGEEVSGRNRPVVTLMGDGSFQYSVQGIYTGVQQKTHVIYVVFQNEEYGILKQ 464 Query: 469 EMK-AGGYLTDGTELHDTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDVVV 527 + G +L + +A G ++VE E+ A A S G ++ V + Sbjct: 465 FAELEQTPNVPGLDLPGLDIVAQGKAYGAKSLKVETLDELKTAYLEALSFKGTSVIVVPI 524 Query: 528 AKE 530 KE Sbjct: 525 TKE 527 >3LQ1-A nrPDB Length = 578 Score = 136 bits (343), Expect = 2e-32, Method: Composition-based stats. Identities = 88/568 (15%), Positives = 180/568 (31%), Gaps = 50/568 (8%) Query: 2 KQTVAAYIA---KTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAG 58 +Q + Y+A + L AGVK G L+ + ++ E A F A Sbjct: 7 EQVLTDYLAAFIEELVQAGVKEAIISPGSRSTPLALMMAEHPILKIYVDVDERSAGFFAL 66 Query: 59 AEAQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQ 118 A+ S V + G + + + + + +P++ + A P G Q Sbjct: 67 GLAKASKRPVVLLCTSGTAAANYFPAVAEANLSQIPLIVLTADRPHELRNVGAPQAMDQL 126 Query: 119 ELF----RECSHYCELVSSPEQI-------PQVLAIAMRKAVLNRGVSVVVLPGDVA--- 164 L+ ++ + +S E + + + IAM+ RG + P Sbjct: 127 HLYGSHVKDFTDMALPENSEEMLRYAKWHGSRAVDIAMKTP---RGPVHLNFPLREPLVP 183 Query: 165 -LKPAPEGATMHWYHAPQPVVTPEEEELRKLAQLLRY--SSNIALMCGS-GCAGAHKELV 220 L+P+P AT +H T E + + +++ + G + +V Sbjct: 184 ILEPSPFTATGKKHHHVHIYYTHEVLDDSSIQKMVTECTGKKGVFVVGPIDKKELEQPMV 243 Query: 221 EFAGKIKAPIVHALRGKEHVEYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGT----QF 276 + A K+ PI+ G + + A+ + L +F Sbjct: 244 DLAKKLGWPILAD-------PLSGLRSYGALDEVVIDQYDAFLKEAEIIDKLTPEVVIRF 296 Query: 277 PYRAFYPTDAKIIQ---------IDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKA 327 ++ +D A V + D + L + + + A Sbjct: 297 GSMPVSKPLKNWLEQLSDIRFYVVDPGAAWKDPIKAVTDMIHCDERFLLDIMQQNMPDDA 356 Query: 328 DRKFLDKALEDYRDARKGLDDLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWA 387 Y + + + + + ++ D A P Sbjct: 357 KDAAWLNGWTSYNKVAREIVLAEMANTTILEEGKIVAELRRLLPDKAGLFIGNSMPIRDV 416 Query: 388 ARYLK-MNGKRRLLGSFNHGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSV 446 Y ++ K ++L + + + ALGA + + + GD F M L Sbjct: 417 DTYFSQIDKKIKMLANRGANGIDGVVSSALGASVVF--QPMFLLIGDLSFYHDMNGLLMA 474 Query: 447 VQMKLPVKIVVFNNSVLG---FVAMEMKAGGYLTDGTELHDTNFARIAEACGITGIRVEK 503 + K+ + IV+ NN G F+ + + + + +F A + Sbjct: 475 KKYKMNLTIVIVNNDGGGIFSFLPQANEPKYFESLFGTSTELDFRFAAAFYDADYHEAKS 534 Query: 504 ASEVDEALQRAFSIDGPVLVDVVVAKEE 531 E++EA+ +A G +++V + E Sbjct: 535 VDELEEAIDKASYHKGLDIIEVKTNRHE 562 >2X7J-A nrPDB Length = 604 Score = 131 bits (330), Expect = 6e-31, Method: Composition-based stats. Identities = 88/557 (15%), Positives = 172/557 (30%), Gaps = 57/557 (10%) Query: 17 GVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQLSGELAVCAGSCGP 76 G+ G L+ I E A F A A+ + + G Sbjct: 45 GITDAVVCPGSRSTPLAVLCAAHPDISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGT 104 Query: 77 GNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFRECSHYCELVSSPEQ 136 + + + H + VP++ + A P G Q + LF + + PE+ Sbjct: 105 AAANFYPAVVEAHYSRVPIIVLTADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEE 164 Query: 137 IPQVL----AIAMRKA----VLNRGVSVVVLPG------DVALKPAPEGATMHWYHAPQP 182 PQ+L +A R A G V +P D++ +P T Sbjct: 165 SPQMLRYIRTLASRAAGEAQKRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTG 224 Query: 183 VVTPEEEELRKLAQLLRYSSNIALMCGSGCAGAHKE-LVEFAGKIKAPIVHALRGKEHVE 241 + + E L +A++L + ++CG + A KE ++ + ++ PI+ Sbjct: 225 TQSVDRESLSDVAEMLAEAEKGMIVCGELHSDADKENIIALSKALQYPILA--------- 275 Query: 242 YDNPYDVGMTGLIGFSSGFHTMMN------------ADTLVLLG------TQFPYRAFYP 283 +P G+ S+ + D ++ G F + P Sbjct: 276 --DPLSNLRNGVHDKSTVIDAYDSFLKDDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDP 333 Query: 284 TDAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLP-LVEEKADRKFLDKALEDYRDA 342 T +I+ ID + + + ++ L ++L+K + + Sbjct: 334 TIQQIV-IDEDGGWRDPTQASAHMIHCNASVFAEEIMAGLTAATRSSEWLEKW--QFVNG 390 Query: 343 RKGLDDLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPT-VWAARYLKMNGKRRLLG 401 R SE L + + H +++ VG + R Sbjct: 391 RFREHLQTISSEDVSFEGNLYRILQHLVPENSSLF--VGNSMPIRDVDTFFEKQDRPFRI 448 Query: 402 SFNHGSMANA--MPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFN 459 N G+ + A+G + V + GD F + L+ ++ +P+ +++ N Sbjct: 449 YSNRGANGIDGVVSSAMGVCEGT-KAPVTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVN 507 Query: 460 NSVLGFVAMEMKAGGYLTDGTELH---DTNFARIAEACGITGIRVEKASEVDEALQRAFS 516 N G + +A +F A G T E A Sbjct: 508 NDGGGIFSFLPQASEKTHFEDLFGTPTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQAD 567 Query: 517 IDGPVLVDVVVAKEELA 533 G L+++ ++ Sbjct: 568 KPGLHLIEIKTDRQSRV 584 >2JLA-A nrPDB Length = 558 Score = 105 bits (262), Expect = 6e-23, Method: Composition-based stats. Identities = 79/550 (14%), Positives = 161/550 (29%), Gaps = 43/550 (7%) Query: 6 AAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNRMGTIEWMSTRHEEVAAFAAGAEAQLSG 65 AA I + L GV+ I G L+ + + E A A++S Sbjct: 13 AAVILEALTRHGVRHICIAPGSRSTPLTLAAAENSAFIHHTHFDERGLGHLALGLAKVSK 72 Query: 66 ELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFRECS 125 + + G +L L + ++ + A P I G Q +F Sbjct: 73 QPVAVIVTSGTAVANLYPALIEAGLTGEKLILLTADRPPELIDCGANQAIRQPGMFASHP 132 Query: 126 HYCELVSSP-EQIPQV-----LAIAMRKAVLNRGVSVVVLPGDVALKPAPEGATMHWYH- 178 + + P + IP + A+ L+ G + P L + + W Sbjct: 133 THSISLPRPTQDIPARWLVSTIDHALGT--LHAGGVHINCPFAEPLYGEMDDTGLSWQQR 190 Query: 179 --------APQPVVTPEEEELRKLAQLLRYSSNIALMCGSGCAGAHKELVEFAGKIKAPI 230 P P E ++ ++ G A K++ +A + P+ Sbjct: 191 LGDWWQDDKPWLREAPRLESEKQRDWFFWRQKRGVVVAGRMSAEEGKKVALWAQTLGWPL 250 Query: 231 VHALRGKEHVEYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFP------YRAFYPT 284 + + +G + + A +V LG+ ++A Sbjct: 251 IGD-----VLSQTGQPLPCADLWLGNAKATSELQQAQIVVQLGSSLTGKRLLQWQASCEP 305 Query: 285 DAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARK 344 + I +D + L+ +I L + + A + + Sbjct: 306 EEYWI-VDDIEGRLDPAHHRGRRLIANIADWLELHPAEKRQPWCVEIPRLAEQAMQAVIA 364 Query: 345 GLDDLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFN 404 D + LA +I + + VG V N Sbjct: 365 RRDAFGE--------AQLAHRICDYLPEQGQLF--VGNSLVVRLIDALSQLPAGYPVYSN 414 Query: 405 HGSMANA--MPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSV 462 G+ + A G Q + +A+ GD + + Q+ P+ ++V NN+ Sbjct: 415 RGASGIDGLLSTAAGVQRAS-GKPTLAIVGDLSALYDLNALALLRQVSAPLVLIVVNNNG 473 Query: 463 LGFVAMEMKAGGYLTDGTELH-DTNFARIAEACGITGIRVEKASEVDEALQRAFSIDGPV 521 ++ + + +F A + R + E++ A A+ Sbjct: 474 GQIFSLLPTPQSERERFYLMPQNVHFEHAAAMFELKYHRPQNWQELETAFADAWRTPTTT 533 Query: 522 LVDVVVAKEE 531 ++++VV + Sbjct: 534 VIEMVVNDTD 543 >5ESS-A nrPDB Length = 574 Score = 91.3 bits (225), Expect = 1e-18, Method: Composition-based stats. Identities = 90/570 (15%), Positives = 165/570 (28%), Gaps = 75/570 (13%) Query: 2 KQTVAAYIAKTLESAGVKRIWGVTGDSLNGLSDSLNR---MGTIEWMSTRHEEVAAFAAG 58 T A + L GV+ + G L+ +L G I E A + A Sbjct: 24 STTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGYLAI 83 Query: 59 AEAQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQ 118 A +G A + G +L + + + VP++ ++A+ P +G+G Q Sbjct: 84 GLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTMEQL 143 Query: 119 ELFRECSHYCELVSSPEQIP---------------QVLAIAMRKAVLNRGVSVVVLPGDV 163 F + E P +VLA A N G +P Sbjct: 144 GYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIPLRE 203 Query: 164 ALKPAPEG---ATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSGCAGAHKELV 220 L P PE T A +P + + S + ++ G G Sbjct: 204 PLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLD-IDLSVDTVVISGHGAG------- 255 Query: 221 EFAGKIKAPIVHALRGKEHVEYDNPYDVGMTGLIGFSSGFHTMMNADTLVLLGTQFPYRA 280 + L V G L + +++LG R Sbjct: 256 ---------VHPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQ---VIMLG-----RP 298 Query: 281 FYPTDAKIIQIDINPASIG---AHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALE 337 ++ D D++ G+ ++T + + A+ Sbjct: 299 TLHRPVSVLLADAEVPVFALTTGPRWPDVS--GNSQATGTRAVTTGAPRPAWLDRCAAMN 356 Query: 338 DYRDARKGLDDLAKPSEKAIHPQYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKR 397 + A A P +H +A +SH P A Sbjct: 357 RHAIAAVREQLAAHPLTTGLH---VAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGI 413 Query: 398 RLLGSFNHGSMANAMPQALGAQAT---------EPER--QVVAMCGDGGFSMLMGDFLSV 446 R+ + + + A+GA P+ + +A+ GD F L Sbjct: 414 RVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIG 473 Query: 447 VQMKLP--VKIVVFNNSVLGFVAMEMKAGGYLTDGTEL-----HDTNFARIAEACGITGI 499 +P + IVV N++ G + + +D + HD + + A + Sbjct: 474 PTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVES- 532 Query: 500 RVEKASEVDEALQRAFSIDGPVLVDVVVAK 529 R + E+ L + + +++V + Sbjct: 533 RQIEVDELGPTLDQPGAGMR--VLEVKADR 560 >5B47-B nrPDB Length = 304 Score = 50.1 bits (118), Expect = 3e-06, Method: Composition-based stats. Identities = 32/169 (18%), Positives = 59/169 (34%), Gaps = 24/169 (14%) Query: 371 ADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAMPQALGAQATEPERQVVAM 430 + +G K+ L S H ++ A G + + P +V+ Sbjct: 35 PKSVVIVSGIGCSG-------KIPHFMNLPISGVHTLHGRSIAFATGIKLSNPSLEVIVN 87 Query: 431 CGDG-GFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAMEMKAGGYLTDGTE-LHDTNF- 487 GDG G + MG F+ + + + + ++V NN V G + + + T+ L N Sbjct: 88 VGDGDGLGIGMGHFVHLGRRNIDIAVLVHNNGVYGLTKGQASPTLHRGEKTKSLPKPNIM 147 Query: 488 -------ARIAEAC----GITGIRVEKASEVDEALQRAFSIDGPVLVDV 525 +A V E+ +++A G LVD+ Sbjct: 148 DAVNPLAVALAAGYTFVARGYAYDVMHLKEL---IKKAILHKGSALVDI 193 >6N2O-B nrPDB Length = 292 Score = 46.2 bits (108), Expect = 4e-05, Method: Composition-based stats. Identities = 23/129 (17%), Positives = 42/129 (32%), Gaps = 13/129 (10%) Query: 409 ANAMPQALGAQATEPERQVVAMCGDG-GFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVA 467 A A G Q P+ VV GDG GFS+ G + + + + V+ +N + G Sbjct: 78 GRAGAVATGTQVARPDLCVVVAGGDGDGFSIGGGHMPHMARKNVNMTYVLMDNGIYGLTK 137 Query: 468 MEMKA----------GGYLTDGTELHDTNFA-RIAEACGITGIRVEKASEVDEALQRAFS 516 + Y ++ + K + E ++ A Sbjct: 138 GQYSPTSRPEMTAYTTPYGGPENPMNPLLYMLTYGATYVAQAF-AGKPKDCAELIKGAME 196 Query: 517 IDGPVLVDV 525 +G V++ Sbjct: 197 HEGFAYVNI 205 >3DVA-A nrPDB Length = 369 Score = 45.1 bits (105), Expect = 8e-05, Method: Composition-based stats. Identities = 41/182 (22%), Positives = 65/182 (35%), Gaps = 35/182 (19%) Query: 411 AMPQALGAQATEPERQVVAMCGDGGFSML--MGDFLSVVQMKLPVKIVVFNNSVLGFVAM 468 A ALG + + + GDGG S K P VV NN + Sbjct: 152 AAGVALGLKMRGKKAVAITYTGDGGTSQGDFYEGINFAGAFKAPAIFVVQNNRFAASTPV 211 Query: 469 EMKAGGYLTDGTELHDTNFARIAEACGITGIRVEKASEV------DEALQRAFSIDGPVL 522 E + A+ A A GI GI+V+ + A +RA + +GP L Sbjct: 212 EKQTVAKTL----------AQKAVAAGIPGIQVDGMDPLAVYAAVKAARERAINGEGPTL 261 Query: 523 VDV--------VVAKEELA--IPPQIKLEQAKGFSLYMLRAIISGRG-------DEVIEL 565 ++ ++ ++ +++ E AK L R + +G + VIE Sbjct: 262 IETLCFRYGPHTMSGDDPTRYRSKELENEWAKKDPLVRFRKFLEAKGLWSEEEENNVIEQ 321 Query: 566 AK 567 AK Sbjct: 322 AK 323 >1YTL-A nrPDB Length = 174 Score = 41.2 bits (95), Expect = 0.001, Method: Composition-based stats. Identities = 24/163 (14%), Positives = 50/163 (30%), Gaps = 34/163 (20%) Query: 157 VVLPGDVALKPAPEGATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSGCAGAH 216 + P DVA P P+ AT+ P +A +++ + L+ G Sbjct: 4 LEQPFDVANIPGPKMATLLEKGKP-------------VANMIKKAKRPLLIVGPDMTDEM 50 Query: 217 -KELVEFAGKIKAPIVHALRGKEHVEYDNPYDVGMTGLIGFSSGFHTMM----------- 264 + + +F K +V D G+ + ++ Sbjct: 51 FERVKKFVEK-DITVVATGSAITRF-----IDAGLGEKVNYAVLHELTQFLLDPDWKGFD 104 Query: 265 ---NADTLVLLGTQFPYRAFYPTDAKIIQIDINPASIGAHSKV 304 N D +++LG+ + + + K I +I + Sbjct: 105 GQGNYDLVLMLGSIYYHGSQMLAAIKNFAPHIRALAIDRYYHP 147 >5B48-A nrPDB Length = 627 Score = 38.9 bits (89), Expect = 0.005, Method: Composition-based stats. Identities = 25/125 (20%), Positives = 43/125 (34%), Gaps = 9/125 (7%) Query: 38 RMGTIEWMSTRHEEVAAFAAGAEAQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLA 97 + GTI + E A A A A + GPG ++ GL N VPV+ Sbjct: 282 KKGTIVVVQAEDELAAINMAIGAALTGVRAA--TATSGPGFSLMVEGLGWAGMNEVPVVI 339 Query: 98 ---IAAHIPSSEIGSGYFQETHPQELFRECSHYCELVSSPEQIPQVLAIAM---RKAVLN 151 I PS+ + + Q +F + ++V + + A+ A Sbjct: 340 TYYIRGG-PSTGLPTRTAQSDLIFPIFAGHGEFPKIVLASGDHAEAFKDAIWALNLAEKY 398 Query: 152 RGVSV 156 + + Sbjct: 399 QTPVI 403 >3CF4-G nrPDB Length = 170 Score = 38.5 bits (88), Expect = 0.009, Method: Composition-based stats. Identities = 18/146 (12%), Positives = 40/146 (27%), Gaps = 14/146 (9%) Query: 192 RKLAQLLRYSSNIALMCGSGC--AGAHKELVEFAGKIKAPIVHALRGKEHVEYDNP---- 245 A+++ + LM G+ +V+ + PI + + Sbjct: 25 EMAAKIISKAKRPLLMVGTLALDPELLDRVVKISKAANIPIAATGSSLAVLADKDVDAKY 84 Query: 246 YDVGMTGLIGFSSGFHTMM---NADTLVLLG-TQFPYRAFYPTDAKIIQIDINPASIGAH 301 + M G + + N D ++ +G +F + G Sbjct: 85 INAHMLGFYLTDPKWPGLDGNGNYDMIITIGFKKFYINQVLSAAKNFSNLKTIAIERGYI 144 Query: 302 SKVDMAL----VGDIKSTLRALLPLV 323 M+ D + L L+ + Sbjct: 145 QNATMSFGNLSKADHYAALDELINAL 170 >1UM9-A nrPDB Length = 367 Score = 37.4 bits (85), Expect = 0.016, Method: Composition-based stats. Identities = 30/141 (21%), Positives = 46/141 (32%), Gaps = 18/141 (12%) Query: 400 LGSFNHGSMANAMPQALGAQATEPERQVVAMCGDGGFSMLMG--DFLSVVQMKLPVKIVV 457 + S + A A+ + + V GDG S P + Sbjct: 142 VASPIASHVPPAAGAAISMKLLRTGQVAVCTFGDGATSEGDWYAGINFAAVQGAPAVFIA 201 Query: 458 FNNSVLGFVAMEMKAGGYLTDGTELHDTNFARIAEACGITGIRVEKASEV------DEAL 511 NN F A+ + T A A A GI G V+ + EA+ Sbjct: 202 ENN----FYAISVDYRHQTHSPT------IADKAHAFGIPGYLVDGMDVLASYYVVKEAV 251 Query: 512 QRAFSIDGPVLVDVVVAKEEL 532 +RA +GP LV++ V + Sbjct: 252 ERARRGEGPSLVELRVYRYGP 272 >3I9V-3 nrPDB Length = 783 Score = 35.5 bits (80), Expect = 0.066, Method: Composition-based stats. Identities = 28/193 (14%), Positives = 56/193 (29%), Gaps = 35/193 (18%) Query: 188 EEELRKLAQLLRYSSNIALMCGSGCAG---AHKELVEFAGKIKAPIVHA--------LRG 236 E + K + + N L+ G+G A + A + A ++ L Sbjct: 487 SEMVAKAKEAWEKAKNPVLILGAGVLQDTVAAERARLLAERKGAKVLAMTPAANARGLEA 546 Query: 237 KEHVE------YDNPYDVGMTGLIGFSSGFHTMMNADTLVL-------LGTQF-----PY 278 + +D P + GF + +V+ L ++ P Sbjct: 547 MGVLPGAKGASWDEP--GALYAYYGFVPPEEALKGKRFVVMHLSHLHPLAERYAHVVLPA 604 Query: 279 RAFYPTDAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALED 338 FY ++ ++ + + G+ + L+ L L E R LE Sbjct: 605 PTFYEKRGHLVNLEGRVLPLSPAPIEN----GEAEGALQVLALLAEALGVRPPFRLHLEA 660 Query: 339 YRDARKGLDDLAK 351 + + A Sbjct: 661 QKALKARKVPEAM 673 >5B46-A nrPDB Length = 628 Score = 34.7 bits (78), Expect = 0.11, Method: Composition-based stats. Identities = 15/61 (24%), Positives = 21/61 (34%), Gaps = 2/61 (3%) Query: 37 NRMGTIEWMSTRHEEVAAFAAGAEAQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVL 96 R G + + E A A A A + GPG + G+ N VPV+ Sbjct: 281 LRKGGVVVVQAEDELAAINMAVGAALTGVRSA--TATSGPGFSLMSEGISWAGMNEVPVV 338 Query: 97 A 97 Sbjct: 339 I 339 >4WBT-A nrPDB Length = 376 Score = 33.9 bits (76), Expect = 0.18, Method: Composition-based stats. Identities = 22/130 (16%), Positives = 42/130 (32%), Gaps = 9/130 (6%) Query: 166 KPAPEGATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSGCAGAHKELVEFAGK 225 P+ A PE +L++ +S + G G G ++V + Sbjct: 51 APSVLLAIRQAAGDTWKYADPENHDLKQALARHLGTSPANIAIGEGIDGLLGQIVRLVVE 110 Query: 226 IKAPIVHALRGKEHVEYDNPYDVGMTGLIGFSSGFHTM---------MNADTLVLLGTQF 276 AP+V +L G Y G + ++ + NA + L Sbjct: 111 AGAPVVTSLGGYPTFNYHVAGHGGRLVTVPYADDREDLEGLLAAVGRENAPLVYLANPDN 170 Query: 277 PYRAFYPTDA 286 P +++P + Sbjct: 171 PMGSWWPAER 180 >5LUC-A nrPDB Length = 403 Score = 33.9 bits (76), Expect = 0.20, Method: Composition-based stats. Identities = 17/100 (17%), Positives = 32/100 (32%), Gaps = 13/100 (13%) Query: 360 QYLAQQISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLL--GSFNHGSMANAMPQALG 417 QY+ Q + + G + AA + L + G A + + +G Sbjct: 76 QYVFQTRNPL----TLVISGSGHCALEAALVNVLEPGDSFLVGANGIWGQRAVDIGERIG 131 Query: 418 AQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVV 457 A +V M D G + + + PV + + Sbjct: 132 A-------RVHPMTKDPGGHYTLQEVEEGLAQHKPVLLFL 164 >1X7Z-A nrPDB Length = 400 Score = 33.5 bits (75), Expect = 0.22, Method: Composition-based stats. Identities = 30/127 (23%), Positives = 46/127 (36%), Gaps = 22/127 (17%) Query: 412 MPQALGAQATEP----ERQVVAMCGDGGFSM--LMGDFLSVVQMKLPVKIVVFNNSVLGF 465 +PQA+GA R V+ G+G S F ++ P+ NN G+ Sbjct: 168 IPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAGFNFAATLECPIIFFCRNN---GY 224 Query: 466 VAMEMKAGGYLTDGTELHDTNFARIAEACGITGIRVEKASEV------DEALQRAFSIDG 519 + Y DG A GI IRV+ EA +RA + + Sbjct: 225 AISTPTSEQYRGDG-------IAARGPGYGIMSIRVDGNDVFAVYNATKEARRRAVAENQ 277 Query: 520 PVLVDVV 526 P L++ + Sbjct: 278 PFLIEAM 284 >5B48-B nrPDB Length = 305 Score = 33.2 bits (74), Expect = 0.29, Method: Composition-based stats. Identities = 26/167 (15%), Positives = 54/167 (32%), Gaps = 20/167 (11%) Query: 371 ADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAMPQALGAQATEPERQVVA- 429 + + +G K+ R S H A+ A G + + P+ V+ Sbjct: 35 TKNVVVVSGIGCSG-------KIPHFFRTPISGVHTLHGRAIAFATGIKLSNPDLVVIVN 87 Query: 430 MCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAMEMKAG------GYLTDGTELH 483 + G F++ + + + +++ +N V G + ++ Sbjct: 88 GGDGDLLGIGAGHFVAAGRRNVDMVVILHDNGVYGLTKGQASPTLKRGEKPKSLPRPNIN 147 Query: 484 D-TNFARIAEACG----ITGIRVEKASEVDEALQRAFSIDGPVLVDV 525 D N +A + G G + E ++ A G L+DV Sbjct: 148 DAVNPIALAISSGYTFVARGY-AYDVKHLKELIKSAIKHKGLALIDV 193 >3JC8-Ba nrPDB Length = 566 Score = 33.2 bits (74), Expect = 0.29, Method: Composition-based stats. Identities = 14/109 (12%), Positives = 34/109 (31%), Gaps = 4/109 (3%) Query: 90 RNHVPVLAIAAHIPSSEIGSGYFQETHPQELFRECSHYCELVSSPEQIPQVLAIAMRKAV 149 V+ + PS + + + + Y ++ + A+ + Sbjct: 82 AEKHLVVPVNRAGPSLIVAMCDPSNIFAVDDLKFLTGYNIETVVASEV--SIREAIERYY 139 Query: 150 LNRGVSVVVLPGDVALKPAPEGATMHWYHAPQPVVTPEEEELRKLAQLL 198 +G S+ + GDV E + + ++ + KL L+ Sbjct: 140 AEKGPSLEDIVGDVGDDI--EVTKEETENIDEMAKAADDAPVVKLVNLI 186 >6GCS-A nrPDB Length = 728 Score = 32.4 bits (72), Expect = 0.51, Method: Composition-based stats. Identities = 39/313 (12%), Positives = 81/313 (25%), Gaps = 34/313 (10%) Query: 84 GLFDCHRNHVPVLAIAAHIP-------SSEIGSGYFQETHPQELFRECSHYCELVSSPEQ 136 + ++A+ +++ +G H FR + ++ E Sbjct: 348 AVAGALVEVESMVALKDMTNALGSENTTTDTPNGNSAPAHGIT-FRSNYLFNSSIAGIED 406 Query: 137 IPQVL---AIAMRKAV---LNRGVSVVVLPGDVALKPAPEGATMHWYHAPQPVVTPEEEE 190 +L R+A + + ++A AT E+ Sbjct: 407 ADAILLVGTNPRREAAVMNARIRKAWLRQELEIASVGPTLDATFDVAELGNTHADLEKAL 466 Query: 191 LRKLAQLLRYSSNIALMCGSGCAGAHKELVEFAGKIKAPIVHALRGKEHVEYD------N 244 + ++L+ + N ++ GSG F I + + + Sbjct: 467 SGEFGEVLKNAKNPLIIVGSGITDREDAG-AFFNTIGKFVESTP---SVLNENWNGYNVL 522 Query: 245 PYDVGMTGLI--GFSSGFHTMMNAD-TLVLLGTQFPYRAFYPTDAKII---QIDINPASI 298 G GF+ + LLG + P DA ++ A Sbjct: 523 QRSASRAGAYDIGFTPSDEASKTTPKMVWLLGADEVAASDIPADAFVVYQGHNGDVGAQF 582 Query: 299 GAHSKVDMALVGDIKSTLRALLPLVEEKADRKFLDKALEDYRDARKGLDDLAKPSEKAIH 358 A + + +A A ED++ R + L A+ Sbjct: 583 ADVVLPGAAYTEKAGTYVNTEGRSQISRAATGPPGGAREDWKILRAVSEYL----GVALP 638 Query: 359 PQYLAQQISHFAA 371 + + A Sbjct: 639 YEDAYEVRDRLAE 651 >2O1S-A nrPDB Length = 621 Score = 32.4 bits (72), Expect = 0.52, Method: Composition-based stats. Identities = 13/72 (18%), Positives = 29/72 (40%), Gaps = 3/72 (4%) Query: 407 SMANAMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMK--LPVKIVVFNNSVLG 464 S++ + A+ A+ R+ V + GDG + F ++ P +V+ N++ + Sbjct: 126 SISAGIGIAVAAEKEGKNRRTVCVIGDGAIT-AGMAFEAMNHAGDIRPDMLVILNDNEMS 184 Query: 465 FVAMEMKAGGYL 476 +L Sbjct: 185 ISENVGALNNHL 196 >3SFW-A nrPDB Length = 461 Score = 32.4 bits (72), Expect = 0.55, Method: Composition-based stats. Identities = 10/49 (20%), Positives = 22/49 (44%) Query: 270 VLLGTQFPYRAFYPTDAKIIQIDINPASIGAHSKVDMALVGDIKSTLRA 318 + +G+ F PT + I ++ + ++ + M + GD+ S L Sbjct: 385 IAVGSDADIVLFDPTVQRTISVETHHMNVDYNPFEGMQVHGDVISVLSR 433 >1ESQ-A nrPDB Length = 284 Score = 32.0 bits (71), Expect = 0.64, Method: Composition-based stats. Identities = 31/132 (23%), Positives = 51/132 (38%), Gaps = 10/132 (7%) Query: 445 SVVQMKLPVKIVVFNNSVLGFVAMEMKAGG--YLTDGTELHDTNFARIAEA--CGITGIR 500 + V+ P+ + NN V F A + A G + + + A+IA A I + Sbjct: 23 TAVRRHSPLVHSITNNVVTNFTANGLLALGASPVMAYAKEEVADMAKIAGALVLNIGTLS 82 Query: 501 VEKASEVDEALQRAFSIDGPVLVDVVVAKEELAIPPQIKLEQAKGFSLYMLRAIISGRGD 560 E + A + A PV++D V A + E A+ + A I G Sbjct: 83 KESVEAMIIAGKSANEHGVPVILDPVGAGATP-----FRTESARDIIREVRLAAIRGNAA 137 Query: 561 EVIE-LAKTNWL 571 E+ + T+WL Sbjct: 138 EIAHTVGVTDWL 149 >2R3S-A nrPDB Length = 335 Score = 32.0 bits (71), Expect = 0.68, Method: Composition-based stats. Identities = 14/59 (23%), Positives = 25/59 (42%), Gaps = 5/59 (8%) Query: 499 IRVEKASEVDEALQRAFSIDGPVLVDVVVAKEELAIPPQIKLEQAKGFSLYMLRAIISG 557 V ++ ++ A +++G V+V + + PP A FSL ML +G Sbjct: 245 FDVATCEQLLRKIKTALAVEGKVIVFDFIPNSDRITPPD-----AAAFSLVMLATTPNG 298 >3QM3-A nrPDB Length = 357 Score = 31.6 bits (70), Expect = 0.93, Method: Composition-based stats. Identities = 12/52 (23%), Positives = 25/52 (48%), Gaps = 2/52 (3%) Query: 473 GGYLTDGTELHDT-NFARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLV 523 + G EL+ ++A+ AE I + V ++ L+ A ++ PV++ Sbjct: 11 KAGVISGDELNKIYDYAK-AEGFAIPAVNVVGTDSINAVLEAAKKVNSPVII 61 >4W8I-A nrPDB Length = 551 Score = 31.6 bits (70), Expect = 1.0, Method: Composition-based stats. Identities = 41/243 (16%), Positives = 71/243 (29%), Gaps = 36/243 (14%) Query: 309 VGDIKSTLRALLPLVEEKADRKF---LDKALEDYRDARKGLDDLAKPSEKAIHPQYLAQQ 365 + D L LP V + +++ L E R R G+ + E+ + PQ + Sbjct: 9 IIDSAYALAKNLPGVNQIIEKELNKELSSTREKLRIQRSGMTLREEIPEEGLSPQDILSA 68 Query: 366 ISHFAADDAIFTCDVGTPTVWAARYLKMNGKRRLLGSFNHGSMANAMPQALGAQATEPER 425 DV + +R L G + A+ + TE + Sbjct: 69 FD----------VDVEKCHFDFLSVTNDSPEREFLVGRGDGKDSGALYAIHPKELTELLK 118 Query: 426 QVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAMEMKAGGYLTDGTELHDT 485 +V + + K P V+ + + G L Sbjct: 119 EV----------YGATALTNPLHDKWPRIN-AMQAEVIRWC--QNLFHGSKEGYGLLTHG 165 Query: 486 NFARIAEACGITGIRVEK----------ASEVDEALQRAFSIDGPVLVDVVVAKEELAIP 535 I EA IR A ++A + G +L+ V V K+ A+ Sbjct: 166 GTTSIIEAMAAYVIRARAKGIDYPEIVVPETAHAAFKKAAELTGAILITVPVDKKTGAVN 225 Query: 536 PQI 538 P + Sbjct: 226 PNV 228 >6CUM-A nrPDB Length = 315 Score = 31.2 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 19/168 (11%), Positives = 52/168 (30%), Gaps = 5/168 (2%) Query: 75 GPGNLHLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFRECSHYCELVSSP 134 G G + + +R +A+ A PSS G + + L+ S Sbjct: 78 GAGKSTTVGAMVGAYRERGLRVAVLAVDPSSPYSGGALL-GDRIRMAAHINDPDVLIRSM 136 Query: 135 EQIPQVLAIAMRKAVLNRGVSVVVLPGDVALKPAPEGATMHWYHAPQPVVT----PEEEE 190 + +A R ++ + V + + P V + Sbjct: 137 AARGHLGGLAAAVPAAIRLLAALSYDLIVLETVGVGQSEIEIAAIADPTVVILNPGAGDA 196 Query: 191 LRKLAQLLRYSSNIALMCGSGCAGAHKELVEFAGKIKAPIVHALRGKE 238 ++ + +++ ++ + GA + + + + P++ + + Sbjct: 197 VQAAKAGVLEVADLVVVNKADRDGADQTVRDLRAETDVPVLKLVAAQG 244 >5GPN-Y nrPDB Length = 727 Score = 31.2 bits (69), Expect = 1.1, Method: Composition-based stats. Identities = 10/77 (12%), Positives = 22/77 (28%), Gaps = 7/77 (9%) Query: 153 GVSVVVLPGDVALKPAPEGATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSGC 212 V+++ P D+ + G + P +Q+L+ + ++ GS Sbjct: 428 KVALIGSPVDLTYRYDHLGDSPKILQDIASGNHP-------FSQILKEAKKPMVVLGSSA 480 Query: 213 AGAHKELVEFAGKIKAP 229 A Sbjct: 481 LQRSDGTAILAAVSNIA 497 >1ULZ-A nrPDB Length = 451 Score = 31.2 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 30/284 (10%), Positives = 81/284 (28%), Gaps = 23/284 (8%) Query: 92 HVPVLAIAAHIPSSEIGSGYFQETHPQELFRECSHYCELVSSPEQIPQVLAIAMRKAVLN 151 +P +AI + S+ E + + + + +++ +A+ Sbjct: 25 GIPTVAIYNEVESTARHVKLADEAYMIG--------TDPLDTYLNKQRIINLALEVGADA 76 Query: 152 RGVSVVVLPGDVALKPAPEGATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSG 211 L + E A + + P V + + ++++ + + G Sbjct: 77 IHPGYGFLAENAEFAKMCEEAGITFIG-PHWKVIELMGDKARSKEVMKKAGVPVVPGSDG 135 Query: 212 CAGAHKELVEFAGKIKAPI----VHALRGKEHVEYDNPYDVGMTGLIGFSSGFHTMMNAD 267 + +E A +I P+ G+ N ++ D Sbjct: 136 VLKSLEEAKALAREIGYPVLLKATAGGGGRGIRICRNEEELVKNYEQASREAEKAFGRGD 195 Query: 268 TLV--LLGTQ--FPYRAFYPTDAKIIQIDINPASIGAHSKVDMALVGDIKSTLRALLPLV 323 L+ + Y+ +I + SI ++ + + +L Sbjct: 196 LLLEKFIENPKHIEYQVLGDKHGNVIHLGERDCSIQRRNQKLVEI------APSLILTPE 249 Query: 324 EEKADRKFLDKALEDYRDARKGLDDLAKPSEKAIHPQYLAQQIS 367 + + + KA ++ G + E ++ + +I Sbjct: 250 KREYYGNIVTKAAKEIGYYNAGTMEFIADQEGNLYFIEMNTRIQ 293 >3B8A-X nrPDB Length = 485 Score = 31.2 bits (69), Expect = 1.3, Method: Composition-based stats. Identities = 22/134 (16%), Positives = 41/134 (30%), Gaps = 15/134 (11%) Query: 24 VTGDSLNGLSDS-LNRMG-TIEWMSTRHEEVAAFAAGAEAQLSGELAVCAGSCGPGNL-- 79 V G + L + +++ IE ++ ++ V A ++ V G+ G Sbjct: 183 VEGHDVVPLLQNEISKRELPIEIVALINDTVGTLIASYYTDPETKMGVIFGTGVNGAFYD 242 Query: 80 --HLINGLFDCHRNHVPVLAIAAHIPSSEIGSGYFQETHPQELFRECSHYCELVSSPEQI 137 I L + +P S + + + L + Y V EQ Sbjct: 243 VVSDIEKLEGKLADDIP-------SNSPMAINCEYGSFDNEHLVLPRTKYDVAVD--EQS 293 Query: 138 PQVLAIAMRKAVLN 151 P+ A K Sbjct: 294 PRPGQQAFEKMTSG 307 >3JB9-S nrPDB Length = 488 Score = 30.8 bits (68), Expect = 1.5, Method: Composition-based stats. Identities = 21/135 (15%), Positives = 48/135 (35%), Gaps = 11/135 (8%) Query: 94 PVLA-IAAHIPSSEIGSGYFQETHPQELFRECSHYCELVSSPEQIPQVLAIAMRKAVLNR 152 PV++ ++ ++ + +ET + ++ +LV P ++P + R Sbjct: 13 PVISRVSGNVYEKRLIEQVIRETSKDPVTQQECTLEDLV--PVKVPDFVR--------PR 62 Query: 153 GVSVVVLPGDVALKPAPEGATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSGC 212 S LP ++L + + +T ++EL L + + Sbjct: 63 PPSATSLPALLSLFQEEWDSVALEQFELRRNLTETKQELSTALYSLDAALRVISRLTKER 122 Query: 213 AGAHKELVEFAGKIK 227 A + L +F+ I Sbjct: 123 DEAREALAKFSDNIG 137 >2YCL-A nrPDB Length = 445 Score = 30.8 bits (68), Expect = 1.7, Method: Composition-based stats. Identities = 11/55 (20%), Positives = 24/55 (43%), Gaps = 3/55 (5%) Query: 188 EEELRKLAQLLRYSSNIALMCGSGCAGAHKELVEFAGKIKAPIVHALRGKEHVEY 242 E+L + ++N L A ++++VE A K P+ + +G + + Sbjct: 164 PEQLAAALET-EGANNPLLYA--ATADNYEQMVELAKKYNVPLTVSAKGLDALAE 215 >1M93-B nrPDB Length = 245 Score = 30.5 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 15/61 (24%), Positives = 24/61 (39%), Gaps = 5/61 (8%) Query: 2 KQTVAAYIAKTLESAGVKRIWGVTGDSLN-----GLSDSLNRMGTIEWMSTRHEEVAAFA 56 K T + + L G+ ++G TGD N D++ I+ E AA + Sbjct: 184 KVTGSYNLVDALVKLGLTEVFGSTGDYSNMSNSDVSVDAMIHKTYIDVNEEYTEAAAATS 243 Query: 57 A 57 A Sbjct: 244 A 244 >1C8O-A nrPDB Length = 300 Score = 30.5 bits (67), Expect = 2.0, Method: Composition-based stats. Identities = 15/61 (24%), Positives = 24/61 (39%), Gaps = 5/61 (8%) Query: 2 KQTVAAYIAKTLESAGVKRIWGVTGDSLN-----GLSDSLNRMGTIEWMSTRHEEVAAFA 56 K T + + L G+ ++G TGD N D++ I+ E AA + Sbjct: 239 KVTGSYNLVDALVKLGLTEVFGSTGDYSNMSNSDVSVDAMIHKTYIDVNEEYTEAAAATS 298 Query: 57 A 57 A Sbjct: 299 A 299 >2ZHG-A nrPDB Length = 154 Score = 30.5 bits (67), Expect = 2.2, Method: Composition-based stats. Identities = 3/31 (9%), Positives = 10/31 (32%) Query: 218 ELVEFAGKIKAPIVHALRGKEHVEYDNPYDV 248 +++ A +I P+ + + Sbjct: 58 AIIKIAQRIGIPLATIGEAFGVLPEGHTLSA 88 >4MB2-A nrPDB Length = 261 Score = 30.1 bits (66), Expect = 2.5, Method: Composition-based stats. Identities = 11/47 (23%), Positives = 17/47 (36%), Gaps = 1/47 (2%) Query: 183 VVTPEEEELRKLAQLLRYSSNIALMCGSGCAGA-HKELVEFAGKIKA 228 + P E +R L + N + A KE +E A + A Sbjct: 51 TIEPAERAMRAAVAKLLLAENPVVSVNGNVAALVPKETIELARALNA 97 >2EBS-A nrPDB Length = 789 Score = 30.1 bits (66), Expect = 2.6, Method: Composition-based stats. Identities = 17/65 (26%), Positives = 27/65 (41%), Gaps = 8/65 (12%) Query: 19 KRIWGVTGDSLNGLSDSLNRMGTIEWMSTR-----HEEVAAFAAGAEAQLSGELAVCAGS 73 ++++G S DS++ G + R HE +A A GA A G+ + Sbjct: 478 QKMFGAPQFSNL---DSIDAAGNFPNVVVRAGSSGHEYDSACARGAYATDGGDAWTIFPT 534 Query: 74 CGPGN 78 C PG Sbjct: 535 CPPGM 539 >6GUA-A nrPDB Length = 822 Score = 30.1 bits (66), Expect = 2.6, Method: Composition-based stats. Identities = 10/29 (34%), Positives = 15/29 (51%) Query: 406 GSMANAMPQALGAQATEPERQVVAMCGDG 434 G + + A GA +PE+ A+ GDG Sbjct: 146 GELGYVLSHATGAILDQPEQIAFAVVGDG 174 >6CGR-k nrPDB Length = 703 Score = 30.1 bits (66), Expect = 3.1, Method: Composition-based stats. Identities = 12/49 (24%), Positives = 20/49 (40%), Gaps = 3/49 (6%) Query: 488 ARIAEACGITGIRVEKASEVDEALQRAFSIDGPVLVDVVVAKEELAIPP 536 + EAC RV + ++ A Q + P L +V + +PP Sbjct: 424 TALTEACAAE--RVVRPHQLSPAGQAELLLRFPAL-EVPLRHPRPVLPP 469 >5U4N-A nrPDB Length = 362 Score = 29.7 bits (65), Expect = 3.3, Method: Composition-based stats. Identities = 8/47 (17%), Positives = 20/47 (42%) Query: 493 ACGITGIRVEKASEVDEALQRAFSIDGPVLVDVVVAKEELAIPPQIK 539 + G+ V ++ ++ A ++ PV+V + A P ++ Sbjct: 25 SYGLPAFNVNNLEQMRAIMEAADQVNAPVIVQASAGARKYAGAPFLR 71 >1P4S-A nrPDB Length = 181 Score = 29.7 bits (65), Expect = 3.5, Method: Composition-based stats. Identities = 8/29 (27%), Positives = 13/29 (44%) Query: 205 ALMCGSGCAGAHKELVEFAGKIKAPIVHA 233 L+ G AG + V+ A K+ P + Sbjct: 3 VLLLGPPGAGKGTQAVKLAEKLGIPQIST 31 >5MLK-A nrPDB Length = 614 Score = 29.7 bits (65), Expect = 3.6, Method: Composition-based stats. Identities = 27/188 (14%), Positives = 53/188 (28%), Gaps = 11/188 (5%) Query: 44 WMSTRHEEVAAFAAGAEAQLSGELAVCAGSCGPGNLHLINGLFDCHRNHVPVLAIAAHIP 103 W + E+ A A+ A ++++ V + G + +I +P +A+ A Sbjct: 4 WSHPQFEKGAHMASHAGSRIARISKVLVANRGEIAVRVIRA---ARDAGLPSVAVYAEPD 60 Query: 104 SSEIGSGYFQETHPQELFRECSHYCELVSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDV 163 + E Y ++L A + L + Sbjct: 61 AESPHVRLADEAFALGGQTSAESYL-------DFAKILDAAAKSGANAIHPGYGFLAENA 113 Query: 164 ALKPAPEGATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMCGSGCAGAHKELVEFA 223 A A + W P P + + + + + E+V FA Sbjct: 114 DFAQAVIDAGLIWIG-PSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFA 172 Query: 224 GKIKAPIV 231 + PI Sbjct: 173 EEYGLPIA 180 >5JLR-A nrPDB Length = 396 Score = 29.7 bits (65), Expect = 3.7, Method: Composition-based stats. Identities = 14/70 (20%), Positives = 23/70 (32%), Gaps = 8/70 (11%) Query: 211 GCAGAHKELVEFAGKIKAPIVHALR-GKEHVEYDNPYDVGMTGLIGFSSGFHTMMNA--- 266 AG L EFA + P+ + G + D G+ + +A Sbjct: 312 DRAGKATALREFAQRAGVPMAQTVAVGDGANDIDMLAAAGLGIAFNAKPALREVADASLS 371 Query: 267 ----DTLVLL 272 DT++ L Sbjct: 372 HPYLDTVLFL 381 >4P2C-A nrPDB Length = 297 Score = 29.3 bits (64), Expect = 4.2, Method: Composition-based stats. Identities = 23/153 (15%), Positives = 43/153 (28%), Gaps = 16/153 (10%) Query: 25 TGDSLNGLSDSL----NRMGTIEWMSTRHEE-VAAFAA---GAEAQLSGELAVCAGSCGP 76 G ++ L R + + R+ VA F + S + G Sbjct: 46 PGSYISVGIRGLDVYQERFDHLRLIIERNNLSVAGFVNTTTNTFYRFSDFAHISLP--GV 103 Query: 77 GNLHLINGLFDCHRNHVPVLAIAA-HIPSSEIGSGYFQ--ETHPQELFRECSHYC---EL 130 + + V L + + + S Y E + RE S Sbjct: 104 TTISMTTDSSYTTPQRVAALERSGMQVSRHSLVSSYLALMEFSGNTMTREASRAVLRFVT 163 Query: 131 VSSPEQIPQVLAIAMRKAVLNRGVSVVVLPGDV 163 V++ + + R+A+ + P DV Sbjct: 164 VTAQALRFRQIQREFRQALSETAPVYTMTPEDV 196 >1S4Q-A nrPDB Length = 228 Score = 29.3 bits (64), Expect = 4.5, Method: Composition-based stats. Identities = 31/170 (18%), Positives = 59/170 (34%), Gaps = 37/170 (21%) Query: 411 AMPQALGAQATEPERQVVAMCGDGGFSMLMGDFLSVVQMKLPVKIVVFNNSVLGFVAMEM 470 P A+G +VV + G + ++ ++P N A Sbjct: 17 GQPAAVG--------RVVVLSGPSAVGKST--VVRCLRERIP-------NLHFSVSATTR 59 Query: 471 KAGGYLTDGTELHDTNFARI------------AEACGITGIRVEKASEVDEALQRAFSID 518 DG + H + R AE G + ++ + + ++ A + Sbjct: 60 APRPGEVDGVDYHFIDPTRFQQLIDQGELLEWAEIHGG----LHRSGTLAQPVRAAAATG 115 Query: 519 GPVLVDVVVAKEELA---IPPQIKLEQAKGFSLYMLRAIISGRGDEVIEL 565 PVL++V +A +P + + A S L+A + GRG E ++ Sbjct: 116 VPVLIEVDLAGARAIKKTMPEAVTVFLAPP-SWQDLQARLIGRGTETADV 164 >4Z5Q-A nrPDB Length = 423 Score = 29.3 bits (64), Expect = 4.7, Method: Composition-based stats. Identities = 24/145 (16%), Positives = 44/145 (30%), Gaps = 21/145 (14%) Query: 96 LAIAAHIPSSEIGSGYFQETHPQELFRECSHYCELVSSPEQIPQVLAIAMR---KAVLNR 152 + I ++ S + + + L + PE IP + +R A Sbjct: 260 ILIGGFETTASEISSFVHVLQQRREL-----WTRLCADPEAIPAAVEELLRFVPFAANGI 314 Query: 153 GVSVVVLPGDVA----LKPAPEGATMHWYHAPQPVVTPEEEELRKLAQLLRYSSNIALMC 208 + V + P + V +E + + + N ++ Sbjct: 315 SPRYALEDMTVGGVLVREGEPVIVDTSAVNRDGLVFDNADEVV------IDRADNRHMVF 368 Query: 209 GSG---CAGAHKELVEFAGKIKAPI 230 G G C GAH VE +KA + Sbjct: 369 GHGAHHCLGAHLARVELQEALKALV 393 >2QVH-A nrPDB Length = 327 Score = 28.9 bits (63), Expect = 5.5, Method: Composition-based stats. Identities = 19/126 (15%), Positives = 40/126 (31%), Gaps = 24/126 (19%) Query: 132 SSPEQIPQVLAIAMRKAVLNRGVSVVVL----PGDVALKPAPEGATMHWYHAPQPVVTPE 187 S + +V A+R A+ RG + + D A++ + QP T + Sbjct: 106 SEANDVARV--EAVRDALGPRGRVRIDVNGAWDVDTAVRMIRLLDRFELEYVEQPCATVD 163 Query: 188 E--------EELRKLAQLLRYSSNIALMCGSGCA----------GAHKELVEFAGKIKAP 229 E + +R + + + + A G + + A + P Sbjct: 164 ELAEVRRRVSVPIAADESIRRAEDPLRVRDAEAADVVVLKVQPLGGVRAALRLAEECGLP 223 Query: 230 IVHALR 235 +V + Sbjct: 224 VVVSSA 229 >2O1X-A nrPDB Length = 629 Score = 28.9 bits (63), Expect = 6.4, Method: Composition-based stats. Identities = 16/57 (28%), Positives = 26/57 (45%), Gaps = 2/57 (3%) Query: 407 SMANAMPQALGAQATEPERQVVAMCGDGGF--SMLMGDFLSVVQMKLPVKIVVFNNS 461 S+ NA+ AL A + V A+ GDG M + ++ M + IV+ +N Sbjct: 128 SLTNALGMALARDAQGKDFHVAAVIGDGSLTGGMALAALNTIGDMGRKMLIVLNDNE 184 Database: ../databases/nrPDB-GO_2019.06.18_sequences.fasta Posted date: Jan 3, 2023 9:05 PM Number of letters in database: 10,336,785 Number of sequences in database: 36,641 Lambda K H 0.308 0.130 0.314 Lambda K H 0.267 0.0403 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,875,639 Number of Sequences: 36641 Number of extensions: 727629 Number of successful extensions: 2841 Number of sequences better than 10.0: 84 Number of HSP's better than 10.0 without gapping: 76 Number of HSP's successfully gapped in prelim test: 48 Number of HSP's that attempted gapping in prelim test: 2453 Number of HSP's gapped (non-prelim): 137 length of query: 572 length of database: 10,336,785 effective HSP length: 102 effective length of query: 470 effective length of database: 6,599,403 effective search space: 3101719410 effective search space used: 3101719410 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.1 bits) S2: 62 (28.5 bits)